id sid tid token lemma pos cord-335975-m6lkrehi 1 1 key key JJ cord-335975-m6lkrehi 2 1 : : : cord-335975-m6lkrehi 2 2 cord-335975-m6lkrehi cord-335975-m6lkrehi NNS cord-335975-m6lkrehi 2 3 authors author NNS cord-335975-m6lkrehi 2 4 : : : cord-335975-m6lkrehi 3 1 nan nan NNP cord-335975-m6lkrehi 3 2 title title NN cord-335975-m6lkrehi 3 3 : : : cord-335975-m6lkrehi 3 4 Proceedings Proceedings NNP cord-335975-m6lkrehi 3 5 of of IN cord-335975-m6lkrehi 3 6 Réanimation Réanimation NNP cord-335975-m6lkrehi 3 7 2018 2018 CD cord-335975-m6lkrehi 3 8 , , , cord-335975-m6lkrehi 3 9 the the DT cord-335975-m6lkrehi 3 10 French French NNP cord-335975-m6lkrehi 3 11 Intensive Intensive NNP cord-335975-m6lkrehi 3 12 Care Care NNP cord-335975-m6lkrehi 3 13 Society Society NNP cord-335975-m6lkrehi 3 14 International International NNP cord-335975-m6lkrehi 3 15 Congress Congress NNP cord-335975-m6lkrehi 3 16 date date NN cord-335975-m6lkrehi 3 17 : : : cord-335975-m6lkrehi 3 18 2018 2018 CD cord-335975-m6lkrehi 3 19 - - HYPH cord-335975-m6lkrehi 3 20 02 02 CD cord-335975-m6lkrehi 3 21 - - HYPH cord-335975-m6lkrehi 3 22 05 05 CD cord-335975-m6lkrehi 3 23 journal journal NN cord-335975-m6lkrehi 3 24 : : : cord-335975-m6lkrehi 3 25 Ann Ann NNP cord-335975-m6lkrehi 3 26 Intensive Intensive NNP cord-335975-m6lkrehi 3 27 Care Care NNP cord-335975-m6lkrehi 3 28 DOI DOI NNP cord-335975-m6lkrehi 3 29 : : : cord-335975-m6lkrehi 3 30 10.1186 10.1186 CD cord-335975-m6lkrehi 3 31 / / SYM cord-335975-m6lkrehi 3 32 s13613 s13613 NN cord-335975-m6lkrehi 3 33 - - HYPH cord-335975-m6lkrehi 3 34 017 017 CD cord-335975-m6lkrehi 3 35 - - HYPH cord-335975-m6lkrehi 3 36 0345 0345 CD cord-335975-m6lkrehi 3 37 - - SYM cord-335975-m6lkrehi 3 38 7 7 CD cord-335975-m6lkrehi 3 39 sha sha NN cord-335975-m6lkrehi 3 40 : : : cord-335975-m6lkrehi 3 41 d715925e85bb35e7656a7c56f0c3919d712f9ee3 d715925e85bb35e7656a7c56f0c3919d712f9ee3 NNP cord-335975-m6lkrehi 3 42 doc_id doc_id CD cord-335975-m6lkrehi 3 43 : : : cord-335975-m6lkrehi 3 44 335975 335975 CD cord-335975-m6lkrehi 3 45 cord_uid cord_uid NN cord-335975-m6lkrehi 3 46 : : : cord-335975-m6lkrehi 4 1 m6lkrehi m6lkrehi NNP cord-335975-m6lkrehi 4 2 nan nan NNP cord-335975-m6lkrehi 4 3 Introduction introduction NN cord-335975-m6lkrehi 4 4 : : : cord-335975-m6lkrehi 4 5 Veno Veno NNP cord-335975-m6lkrehi 4 6 - - HYPH cord-335975-m6lkrehi 4 7 venous venous JJ cord-335975-m6lkrehi 4 8 extracorporeal extracorporeal NN cord-335975-m6lkrehi 4 9 CO CO NNP cord-335975-m6lkrehi 4 10 2 2 CD cord-335975-m6lkrehi 4 11 removal removal NN cord-335975-m6lkrehi 4 12 ( ( -LRB- cord-335975-m6lkrehi 4 13 ECCO2R ECCO2R NNP cord-335975-m6lkrehi 4 14 ) ) -RRB- cord-335975-m6lkrehi 4 15 is be VBZ cord-335975-m6lkrehi 4 16 a a DT cord-335975-m6lkrehi 4 17 promising promising JJ cord-335975-m6lkrehi 4 18 new new JJ cord-335975-m6lkrehi 4 19 therapeutic therapeutic JJ cord-335975-m6lkrehi 4 20 option option NN cord-335975-m6lkrehi 4 21 in in IN cord-335975-m6lkrehi 4 22 the the DT cord-335975-m6lkrehi 4 23 critical critical JJ cord-335975-m6lkrehi 4 24 care care NN cord-335975-m6lkrehi 4 25 setting setting NN cord-335975-m6lkrehi 4 26 . . . cord-335975-m6lkrehi 5 1 We -PRON- PRP cord-335975-m6lkrehi 5 2 conducted conduct VBD cord-335975-m6lkrehi 5 3 a a DT cord-335975-m6lkrehi 5 4 prospective prospective JJ cord-335975-m6lkrehi 5 5 observational observational JJ cord-335975-m6lkrehi 5 6 study study NN cord-335975-m6lkrehi 5 7 of of IN cord-335975-m6lkrehi 5 8 the the DT cord-335975-m6lkrehi 5 9 use use NN cord-335975-m6lkrehi 5 10 of of IN cord-335975-m6lkrehi 5 11 ECCO2R ECCO2R NNP cord-335975-m6lkrehi 5 12 in in IN cord-335975-m6lkrehi 5 13 selected select VBN cord-335975-m6lkrehi 5 14 voluntary voluntary JJ cord-335975-m6lkrehi 5 15 centers center NNS cord-335975-m6lkrehi 5 16 during during IN cord-335975-m6lkrehi 5 17 2 2 CD cord-335975-m6lkrehi 5 18 years year NNS cord-335975-m6lkrehi 5 19 aiming aim VBG cord-335975-m6lkrehi 5 20 to to TO cord-335975-m6lkrehi 5 21 assess assess VB cord-335975-m6lkrehi 5 22 the the DT cord-335975-m6lkrehi 5 23 prevalence prevalence NN cord-335975-m6lkrehi 5 24 of of IN cord-335975-m6lkrehi 5 25 the the DT cord-335975-m6lkrehi 5 26 ECCO2R ECCO2R NNP cord-335975-m6lkrehi 5 27 use use NN cord-335975-m6lkrehi 5 28 mainly mainly RB cord-335975-m6lkrehi 5 29 among among IN cord-335975-m6lkrehi 5 30 COPD COPD NNP cord-335975-m6lkrehi 5 31 and and CC cord-335975-m6lkrehi 5 32 ARDS ARDS NNP cord-335975-m6lkrehi 5 33 patients patient NNS cord-335975-m6lkrehi 5 34 . . . cord-335975-m6lkrehi 6 1 Patients patient NNS cord-335975-m6lkrehi 6 2 and and CC cord-335975-m6lkrehi 6 3 methods method NNS cord-335975-m6lkrehi 6 4 : : : cord-335975-m6lkrehi 6 5 Two two CD cord-335975-m6lkrehi 6 6 medical medical JJ cord-335975-m6lkrehi 6 7 devices device NNS cord-335975-m6lkrehi 6 8 : : : cord-335975-m6lkrehi 6 9 Hemolung Hemolung NNP cord-335975-m6lkrehi 6 10 ( ( -LRB- cord-335975-m6lkrehi 6 11 Alung Alung NNP cord-335975-m6lkrehi 6 12 Technologies Technologies NNPS cord-335975-m6lkrehi 6 13 , , , cord-335975-m6lkrehi 6 14 Pittsburgh Pittsburgh NNP cord-335975-m6lkrehi 6 15 , , , cord-335975-m6lkrehi 6 16 USA USA NNP cord-335975-m6lkrehi 6 17 ) ) -RRB- cord-335975-m6lkrehi 6 18 and and CC cord-335975-m6lkrehi 6 19 iLA iLA `` cord-335975-m6lkrehi 6 20 Activve Activve NNP cord-335975-m6lkrehi 6 21 ( ( -LRB- cord-335975-m6lkrehi 6 22 Xenios Xenios NNP cord-335975-m6lkrehi 6 23 Novalung Novalung NNP cord-335975-m6lkrehi 6 24 , , , cord-335975-m6lkrehi 6 25 Heilbronn Heilbronn NNP cord-335975-m6lkrehi 6 26 , , , cord-335975-m6lkrehi 6 27 Germany Germany NNP cord-335975-m6lkrehi 6 28 ) ) -RRB- cord-335975-m6lkrehi 6 29 were be VBD cord-335975-m6lkrehi 6 30 selected select VBN cord-335975-m6lkrehi 6 31 after after IN cord-335975-m6lkrehi 6 32 literature literature NN cord-335975-m6lkrehi 6 33 and and CC cord-335975-m6lkrehi 6 34 medico medico NN cord-335975-m6lkrehi 6 35 - - HYPH cord-335975-m6lkrehi 6 36 economic economic JJ cord-335975-m6lkrehi 6 37 evaluations evaluation NNS cord-335975-m6lkrehi 6 38 . . . cord-335975-m6lkrehi 7 1 A a DT cord-335975-m6lkrehi 7 2 specific specific JJ cord-335975-m6lkrehi 7 3 medical medical JJ cord-335975-m6lkrehi 7 4 and and CC cord-335975-m6lkrehi 7 5 nurses nurse NNS cord-335975-m6lkrehi 7 6 training training NN cord-335975-m6lkrehi 7 7 was be VBD cord-335975-m6lkrehi 7 8 provided provide VBN cord-335975-m6lkrehi 7 9 in in IN cord-335975-m6lkrehi 7 10 Table Table NNP cord-335975-m6lkrehi 7 11 1 1 CD cord-335975-m6lkrehi 7 12 Characteristics characteristic NNS cord-335975-m6lkrehi 7 13 of of IN cord-335975-m6lkrehi 7 14 130 130 CD cord-335975-m6lkrehi 7 15 patients patient NNS cord-335975-m6lkrehi 7 16 with with IN cord-335975-m6lkrehi 7 17 known known JJ cord-335975-m6lkrehi 7 18 or or CC cord-335975-m6lkrehi 7 19 de de FW cord-335975-m6lkrehi 7 20 novo novo NNP cord-335975-m6lkrehi 7 21 SVV SVV NNP cord-335975-m6lkrehi 7 22 ( ( -LRB- cord-335975-m6lkrehi 7 23 small small JJ cord-335975-m6lkrehi 7 24 - - HYPH cord-335975-m6lkrehi 7 25 vessel vessel NN cord-335975-m6lkrehi 7 26 vasculitis vasculitis NN cord-335975-m6lkrehi 7 27 ) ) -RRB- cord-335975-m6lkrehi 7 28 admitted admit VBD cord-335975-m6lkrehi 7 29 to to IN cord-335975-m6lkrehi 7 30 the the DT cord-335975-m6lkrehi 7 31 intensive intensive JJ cord-335975-m6lkrehi 7 32 care care NN cord-335975-m6lkrehi 7 33 unit unit NN cord-335975-m6lkrehi 7 34 for for IN cord-335975-m6lkrehi 7 35 Acute acute JJ cord-335975-m6lkrehi 7 36 Respiratory respiratory JJ cord-335975-m6lkrehi 7 37 Failure failure NN cord-335975-m6lkrehi 7 38 ( ( -LRB- cord-335975-m6lkrehi 7 39 ARF arf NN cord-335975-m6lkrehi 7 40 ) ) -RRB- cord-335975-m6lkrehi 8 1 All all DT cord-335975-m6lkrehi 8 2 ARF ARF NNP cord-335975-m6lkrehi 8 3 ( ( -LRB- cord-335975-m6lkrehi 8 4 n n NN cord-335975-m6lkrehi 8 5 = = SYM cord-335975-m6lkrehi 8 6 130 130 CD cord-335975-m6lkrehi 8 7 ) ) -RRB- cord-335975-m6lkrehi 9 1 Immune immune JJ cord-335975-m6lkrehi 9 2 ARF arf NN cord-335975-m6lkrehi 10 1 ( ( -LRB- cord-335975-m6lkrehi 10 2 n n NN cord-335975-m6lkrehi 10 3 = = SYM cord-335975-m6lkrehi 10 4 67 67 CD cord-335975-m6lkrehi 10 5 ) ) -RRB- cord-335975-m6lkrehi 11 1 Non non JJ cord-335975-m6lkrehi 11 2 immune immune JJ cord-335975-m6lkrehi 11 3 ARF arf NN cord-335975-m6lkrehi 12 1 ( ( -LRB- cord-335975-m6lkrehi 12 2 n n NN cord-335975-m6lkrehi 12 3 = = SYM cord-335975-m6lkrehi 12 4 63 63 CD cord-335975-m6lkrehi 12 5 ) ) -RRB- cord-335975-m6lkrehi 13 1 p p NNP cord-335975-m6lkrehi 13 2 Age Age NNP cord-335975-m6lkrehi 13 3 , , , cord-335975-m6lkrehi 13 4 Introduction introduction NN cord-335975-m6lkrehi 13 5 : : : cord-335975-m6lkrehi 13 6 Ineffective ineffective JJ cord-335975-m6lkrehi 13 7 triggering triggering NN cord-335975-m6lkrehi 13 8 is be VBZ cord-335975-m6lkrehi 13 9 frequent frequent JJ cord-335975-m6lkrehi 13 10 during during IN cord-335975-m6lkrehi 13 11 pressure pressure NN cord-335975-m6lkrehi 13 12 support support NN cord-335975-m6lkrehi 13 13 ventilation ventilation NN cord-335975-m6lkrehi 13 14 ( ( -LRB- cord-335975-m6lkrehi 13 15 PSV PSV NNP cord-335975-m6lkrehi 13 16 ) ) -RRB- cord-335975-m6lkrehi 13 17 . . . cord-335975-m6lkrehi 14 1 Its -PRON- PRP$ cord-335975-m6lkrehi 14 2 occurrence occurrence NN cord-335975-m6lkrehi 14 3 is be VBZ cord-335975-m6lkrehi 14 4 favored favor VBN cord-335975-m6lkrehi 14 5 by by IN cord-335975-m6lkrehi 14 6 dynamic dynamic JJ cord-335975-m6lkrehi 14 7 hyperinflation hyperinflation NN cord-335975-m6lkrehi 14 8 that that WDT cord-335975-m6lkrehi 14 9 may may MD cord-335975-m6lkrehi 14 10 arise arise VB cord-335975-m6lkrehi 14 11 when when WRB cord-335975-m6lkrehi 14 12 increasing increase VBG cord-335975-m6lkrehi 14 13 the the DT cord-335975-m6lkrehi 14 14 pressure pressure NN cord-335975-m6lkrehi 14 15 support support NN cord-335975-m6lkrehi 14 16 level level NN cord-335975-m6lkrehi 14 17 ( ( -LRB- cord-335975-m6lkrehi 14 18 PSL PSL NNP cord-335975-m6lkrehi 14 19 ) ) -RRB- cord-335975-m6lkrehi 14 20 . . . cord-335975-m6lkrehi 15 1 Decreasing decrease VBG cord-335975-m6lkrehi 15 2 the the DT cord-335975-m6lkrehi 15 3 PSL PSL NNP cord-335975-m6lkrehi 15 4 however however RB cord-335975-m6lkrehi 15 5 fails fail VBZ cord-335975-m6lkrehi 15 6 to to TO cord-335975-m6lkrehi 15 7 suppress suppress VB cord-335975-m6lkrehi 15 8 ineffective ineffective JJ cord-335975-m6lkrehi 15 9 triggering triggering NN cord-335975-m6lkrehi 15 10 in in IN cord-335975-m6lkrehi 15 11 a a DT cord-335975-m6lkrehi 15 12 subgroup subgroup NN cord-335975-m6lkrehi 15 13 of of IN cord-335975-m6lkrehi 15 14 patients patient NNS cord-335975-m6lkrehi 15 15 that that WDT cord-335975-m6lkrehi 15 16 are be VBP cord-335975-m6lkrehi 15 17 therefore therefore RB cord-335975-m6lkrehi 15 18 exposed expose VBN cord-335975-m6lkrehi 15 19 to to IN cord-335975-m6lkrehi 15 20 refractory refractory JJ cord-335975-m6lkrehi 15 21 ineffective ineffective JJ cord-335975-m6lkrehi 15 22 triggering triggering NN cord-335975-m6lkrehi 15 23 . . . cord-335975-m6lkrehi 16 1 Proportional proportional JJ cord-335975-m6lkrehi 16 2 assist assist VB cord-335975-m6lkrehi 16 3 ventilation ventilation NN cord-335975-m6lkrehi 16 4 with with IN cord-335975-m6lkrehi 16 5 load load NN cord-335975-m6lkrehi 16 6 - - HYPH cord-335975-m6lkrehi 16 7 adjustable adjustable JJ cord-335975-m6lkrehi 16 8 gain gain NN cord-335975-m6lkrehi 16 9 factors factor NNS cord-335975-m6lkrehi 16 10 ( ( -LRB- cord-335975-m6lkrehi 16 11 PAV pav NN cord-335975-m6lkrehi 16 12 + + CC cord-335975-m6lkrehi 16 13 ) ) -RRB- cord-335975-m6lkrehi 16 14 decreases decrease VBZ cord-335975-m6lkrehi 16 15 the the DT cord-335975-m6lkrehi 16 16 incidence incidence NN cord-335975-m6lkrehi 16 17 of of IN cord-335975-m6lkrehi 16 18 ineffective ineffective JJ cord-335975-m6lkrehi 16 19 triggering triggering NN cord-335975-m6lkrehi 16 20 in in IN cord-335975-m6lkrehi 16 21 unselected unselected JJ cord-335975-m6lkrehi 16 22 patients patient NNS cord-335975-m6lkrehi 16 23 but but CC cord-335975-m6lkrehi 17 1 its -PRON- PRP$ cord-335975-m6lkrehi 17 2 effect effect NN cord-335975-m6lkrehi 17 3 on on IN cord-335975-m6lkrehi 17 4 refractory refractory JJ cord-335975-m6lkrehi 17 5 asynchrony asynchrony NN cord-335975-m6lkrehi 17 6 during during IN cord-335975-m6lkrehi 17 7 PSV PSV NNP cord-335975-m6lkrehi 17 8 is be VBZ cord-335975-m6lkrehi 17 9 unknown unknown JJ cord-335975-m6lkrehi 17 10 . . . cord-335975-m6lkrehi 18 1 The the DT cord-335975-m6lkrehi 18 2 main main JJ cord-335975-m6lkrehi 18 3 aim aim NN cord-335975-m6lkrehi 18 4 of of IN cord-335975-m6lkrehi 18 5 our -PRON- PRP$ cord-335975-m6lkrehi 18 6 study study NN cord-335975-m6lkrehi 18 7 was be VBD cord-335975-m6lkrehi 18 8 to to TO cord-335975-m6lkrehi 18 9 assess assess VB cord-335975-m6lkrehi 18 10 the the DT cord-335975-m6lkrehi 18 11 effect effect NN cord-335975-m6lkrehi 18 12 . . . cord-335975-m6lkrehi 19 1 The the DT cord-335975-m6lkrehi 19 2 median median JJ cord-335975-m6lkrehi 19 3 gain gain NN cord-335975-m6lkrehi 19 4 during during IN cord-335975-m6lkrehi 19 5 PAV PAV NNP cord-335975-m6lkrehi 19 6 + + CC cord-335975-m6lkrehi 19 7 was be VBD cord-335975-m6lkrehi 19 8 70 70 CD cord-335975-m6lkrehi 19 9 % % NN cord-335975-m6lkrehi 19 10 [ [ -LRB- cord-335975-m6lkrehi 19 11 63 63 CD cord-335975-m6lkrehi 19 12 ] ] -RRB- cord-335975-m6lkrehi 19 13 [ [ -LRB- cord-335975-m6lkrehi 19 14 64 64 CD cord-335975-m6lkrehi 19 15 ] ] -RRB- cord-335975-m6lkrehi 19 16 [ [ -LRB- cord-335975-m6lkrehi 19 17 65 65 CD cord-335975-m6lkrehi 19 18 ] ] -RRB- cord-335975-m6lkrehi 19 19 [ [ -LRB- cord-335975-m6lkrehi 19 20 66 66 CD cord-335975-m6lkrehi 19 21 ] ] -RRB- cord-335975-m6lkrehi 19 22 [ [ -LRB- cord-335975-m6lkrehi 19 23 67 67 CD cord-335975-m6lkrehi 19 24 ] ] -RRB- cord-335975-m6lkrehi 20 1 [ [ -LRB- cord-335975-m6lkrehi 20 2 68 68 CD cord-335975-m6lkrehi 20 3 ] ] -RRB- cord-335975-m6lkrehi 20 4 [ [ -LRB- cord-335975-m6lkrehi 20 5 69 69 CD cord-335975-m6lkrehi 20 6 ] ] -RRB- cord-335975-m6lkrehi 20 7 [ [ -LRB- cord-335975-m6lkrehi 20 8 70 70 CD cord-335975-m6lkrehi 20 9 ] ] -RRB- cord-335975-m6lkrehi 20 10 [ [ -LRB- cord-335975-m6lkrehi 20 11 71 71 CD cord-335975-m6lkrehi 20 12 ] ] -RRB- cord-335975-m6lkrehi 20 13 [ [ -LRB- cord-335975-m6lkrehi 20 14 72 72 CD cord-335975-m6lkrehi 20 15 ] ] -RRB- cord-335975-m6lkrehi 20 16 [ [ -LRB- cord-335975-m6lkrehi 20 17 73 73 CD cord-335975-m6lkrehi 20 18 ] ] -RRB- cord-335975-m6lkrehi 20 19 . . . cord-335975-m6lkrehi 21 1 The the DT cord-335975-m6lkrehi 21 2 asynchrony asynchrony NN cord-335975-m6lkrehi 21 3 index index NN cord-335975-m6lkrehi 21 4 was be VBD cord-335975-m6lkrehi 21 5 significantly significantly RB cord-335975-m6lkrehi 21 6 lower low JJR cord-335975-m6lkrehi 21 7 with with IN cord-335975-m6lkrehi 21 8 PAV PAV NNP cord-335975-m6lkrehi 21 9 + + CC cord-335975-m6lkrehi 21 10 than than IN cord-335975-m6lkrehi 21 11 PSV PSV NNP cord-335975-m6lkrehi 21 12 ( ( -LRB- cord-335975-m6lkrehi 21 13 3 3 CD cord-335975-m6lkrehi 21 14 % % NN cord-335975-m6lkrehi 21 15 [ [ -LRB- cord-335975-m6lkrehi 21 16 2 2 LS cord-335975-m6lkrehi 21 17 ] ] -RRB- cord-335975-m6lkrehi 21 18 [ [ -LRB- cord-335975-m6lkrehi 21 19 3 3 CD cord-335975-m6lkrehi 21 20 ] ] -RRB- cord-335975-m6lkrehi 21 21 [ [ -LRB- cord-335975-m6lkrehi 21 22 4 4 CD cord-335975-m6lkrehi 21 23 ] ] -RRB- cord-335975-m6lkrehi 21 24 [ [ -LRB- cord-335975-m6lkrehi 21 25 5 5 CD cord-335975-m6lkrehi 21 26 ] ] -RRB- cord-335975-m6lkrehi 21 27 [ [ -LRB- cord-335975-m6lkrehi 21 28 6 6 CD cord-335975-m6lkrehi 21 29 ] ] -RRB- cord-335975-m6lkrehi 21 30 [ [ -LRB- cord-335975-m6lkrehi 21 31 7 7 CD cord-335975-m6lkrehi 21 32 ] ] -RRB- cord-335975-m6lkrehi 21 33 [ [ -LRB- cord-335975-m6lkrehi 21 34 8 8 CD cord-335975-m6lkrehi 21 35 ] ] -RRB- cord-335975-m6lkrehi 21 36 vs. vs. IN cord-335975-m6lkrehi 21 37 24 24 CD cord-335975-m6lkrehi 21 38 % % NN cord-335975-m6lkrehi 21 39 respectively respectively RB cord-335975-m6lkrehi 21 40 , , , cord-335975-m6lkrehi 21 41 p p NN cord-335975-m6lkrehi 21 42 = = SYM cord-335975-m6lkrehi 21 43 0.02 0.02 CD cord-335975-m6lkrehi 21 44 ) ) -RRB- cord-335975-m6lkrehi 21 45 . . . cord-335975-m6lkrehi 22 1 Moreover moreover RB cord-335975-m6lkrehi 22 2 , , , cord-335975-m6lkrehi 22 3 the the DT cord-335975-m6lkrehi 22 4 asynchrony asynchrony NNP cord-335975-m6lkrehi 22 5 index index NN cord-335975-m6lkrehi 22 6 decreased decrease VBD cord-335975-m6lkrehi 22 7 in in IN cord-335975-m6lkrehi 22 8 every every DT cord-335975-m6lkrehi 22 9 patient patient NN cord-335975-m6lkrehi 22 10 with with IN cord-335975-m6lkrehi 22 11 PAV PAV NNP cord-335975-m6lkrehi 22 12 + + CC cord-335975-m6lkrehi 23 1 ( ( -LRB- cord-335975-m6lkrehi 23 2 Fig Fig NNP cord-335975-m6lkrehi 23 3 . . NNP cord-335975-m6lkrehi 23 4 1 1 CD cord-335975-m6lkrehi 23 5 ) ) -RRB- cord-335975-m6lkrehi 23 6 . . . cord-335975-m6lkrehi 24 1 Noticeably noticeably RB cord-335975-m6lkrehi 24 2 , , , cord-335975-m6lkrehi 24 3 the the DT cord-335975-m6lkrehi 24 4 tidal tidal JJ cord-335975-m6lkrehi 24 5 volume volume NN cord-335975-m6lkrehi 24 6 was be VBD cord-335975-m6lkrehi 24 7 already already RB cord-335975-m6lkrehi 24 8 protective protective JJ cord-335975-m6lkrehi 24 9 in in IN cord-335975-m6lkrehi 24 10 PSV PSV NNP cord-335975-m6lkrehi 24 11 and and CC cord-335975-m6lkrehi 24 12 decreased decrease VBD cord-335975-m6lkrehi 24 13 even even RB cord-335975-m6lkrehi 24 14 more more RBR cord-335975-m6lkrehi 24 15 during during IN cord-335975-m6lkrehi 24 16 PAV PAV NNP cord-335975-m6lkrehi 24 17 + + CC cord-335975-m6lkrehi 24 18 ( ( -LRB- cord-335975-m6lkrehi 24 19 5.71 5.71 CD cord-335975-m6lkrehi 24 20 mL ml NN cord-335975-m6lkrehi 24 21 kg kg NN cord-335975-m6lkrehi 24 22 [ [ -LRB- cord-335975-m6lkrehi 24 23 4.6 4.6 CD cord-335975-m6lkrehi 24 24 - - SYM cord-335975-m6lkrehi 24 25 9.3 9.3 CD cord-335975-m6lkrehi 24 26 ] ] -RRB- cord-335975-m6lkrehi 24 27 vs. vs. NN cord-335975-m6lkrehi 24 28 5.71 5.71 CD cord-335975-m6lkrehi 24 29 mL ml XX cord-335975-m6lkrehi 24 30 [ [ -LRB- cord-335975-m6lkrehi 24 31 1.8 1.8 CD cord-335975-m6lkrehi 24 32 - - SYM cord-335975-m6lkrehi 24 33 7 7 CD cord-335975-m6lkrehi 24 34 .1 .1 CD cord-335975-m6lkrehi 24 35 ] ] -RRB- cord-335975-m6lkrehi 25 1 respectively respectively RB cord-335975-m6lkrehi 25 2 , , , cord-335975-m6lkrehi 25 3 p p NN cord-335975-m6lkrehi 25 4 = = SYM cord-335975-m6lkrehi 25 5 0.03 0.03 CD cord-335975-m6lkrehi 25 6 ) ) -RRB- cord-335975-m6lkrehi 25 7 ; ; : cord-335975-m6lkrehi 25 8 and and CC cord-335975-m6lkrehi 25 9 the the DT cord-335975-m6lkrehi 25 10 neural neural JJ cord-335975-m6lkrehi 25 11 respiratory respiratory JJ cord-335975-m6lkrehi 25 12 rate rate NN cord-335975-m6lkrehi 25 13 was be VBD cord-335975-m6lkrehi 25 14 high high JJ cord-335975-m6lkrehi 25 15 in in IN cord-335975-m6lkrehi 25 16 both both DT cord-335975-m6lkrehi 25 17 modes mode NNS cord-335975-m6lkrehi 25 18 ( ( -LRB- cord-335975-m6lkrehi 25 19 41 41 CD cord-335975-m6lkrehi 25 20 cycles cycle NNS cord-335975-m6lkrehi 25 21 min min NNP cord-335975-m6lkrehi 25 22 in in IN cord-335975-m6lkrehi 25 23 PSV PSV NNP cord-335975-m6lkrehi 26 1 vs. vs. FW cord-335975-m6lkrehi 26 2 40 40 CD cord-335975-m6lkrehi 26 3 [ [ -LRB- cord-335975-m6lkrehi 26 4 28 28 CD cord-335975-m6lkrehi 26 5 ] ] -RRB- cord-335975-m6lkrehi 26 6 [ [ -LRB- cord-335975-m6lkrehi 26 7 29 29 CD cord-335975-m6lkrehi 26 8 ] ] -RRB- cord-335975-m6lkrehi 27 1 [ [ -LRB- cord-335975-m6lkrehi 27 2 30 30 CD cord-335975-m6lkrehi 27 3 ] ] -RRB- cord-335975-m6lkrehi 27 4 [ [ -LRB- cord-335975-m6lkrehi 27 5 31 31 CD cord-335975-m6lkrehi 27 6 ] ] -RRB- cord-335975-m6lkrehi 28 1 [ [ -LRB- cord-335975-m6lkrehi 28 2 32 32 CD cord-335975-m6lkrehi 28 3 ] ] -RRB- cord-335975-m6lkrehi 28 4 [ [ -LRB- cord-335975-m6lkrehi 28 5 33 33 CD cord-335975-m6lkrehi 28 6 ] ] -RRB- cord-335975-m6lkrehi 28 7 [ [ -LRB- cord-335975-m6lkrehi 28 8 34 34 CD cord-335975-m6lkrehi 28 9 ] ] -RRB- cord-335975-m6lkrehi 29 1 [ [ -LRB- cord-335975-m6lkrehi 29 2 35 35 CD cord-335975-m6lkrehi 29 3 ] ] -RRB- cord-335975-m6lkrehi 29 4 [ [ -LRB- cord-335975-m6lkrehi 29 5 36 36 CD cord-335975-m6lkrehi 29 6 ] ] -RRB- cord-335975-m6lkrehi 30 1 [ [ -LRB- cord-335975-m6lkrehi 30 2 37 37 CD cord-335975-m6lkrehi 30 3 ] ] -RRB- cord-335975-m6lkrehi 30 4 [ [ -LRB- cord-335975-m6lkrehi 30 5 38 38 CD cord-335975-m6lkrehi 30 6 ] ] -RRB- cord-335975-m6lkrehi 31 1 [ [ -LRB- cord-335975-m6lkrehi 31 2 39 39 CD cord-335975-m6lkrehi 31 3 ] ] -RRB- cord-335975-m6lkrehi 32 1 [ [ -LRB- cord-335975-m6lkrehi 32 2 40 40 CD cord-335975-m6lkrehi 32 3 ] ] -RRB- cord-335975-m6lkrehi 32 4 [ [ -LRB- cord-335975-m6lkrehi 32 5 41 41 CD cord-335975-m6lkrehi 32 6 ] ] -RRB- cord-335975-m6lkrehi 33 1 [ [ -LRB- cord-335975-m6lkrehi 33 2 42 42 CD cord-335975-m6lkrehi 33 3 ] ] -RRB- cord-335975-m6lkrehi 33 4 [ [ -LRB- cord-335975-m6lkrehi 33 5 43 43 CD cord-335975-m6lkrehi 33 6 ] ] -RRB- cord-335975-m6lkrehi 33 7 [ [ -LRB- cord-335975-m6lkrehi 33 8 44 44 CD cord-335975-m6lkrehi 33 9 ] ] -RRB- cord-335975-m6lkrehi 33 10 in in IN cord-335975-m6lkrehi 33 11 PAV PAV NNP cord-335975-m6lkrehi 33 12 + + CC cord-335975-m6lkrehi 33 13 , , , cord-335975-m6lkrehi 33 14 p p NN cord-335975-m6lkrehi 33 15 = = SYM cord-335975-m6lkrehi 33 16 0.61 0.61 CD cord-335975-m6lkrehi 33 17 ) ) -RRB- cord-335975-m6lkrehi 33 18 . . . cord-335975-m6lkrehi 34 1 Total total JJ cord-335975-m6lkrehi 34 2 esophageal esophageal JJ cord-335975-m6lkrehi 34 3 Pressure Pressure NNP cord-335975-m6lkrehi 34 4 - - HYPH cord-335975-m6lkrehi 34 5 Time Time NNP cord-335975-m6lkrehi 34 6 Product product NN cord-335975-m6lkrehi 34 7 ( ( -LRB- cord-335975-m6lkrehi 34 8 PTPes PTPes NNP cord-335975-m6lkrehi 34 9 ) ) -RRB- cord-335975-m6lkrehi 34 10 did do VBD cord-335975-m6lkrehi 34 11 not not RB cord-335975-m6lkrehi 34 12 significantly significantly RB cord-335975-m6lkrehi 34 13 differ differ VB cord-335975-m6lkrehi 34 14 between between IN cord-335975-m6lkrehi 34 15 the the DT cord-335975-m6lkrehi 34 16 two two CD cord-335975-m6lkrehi 34 17 modes mode NNS cord-335975-m6lkrehi 34 18 but but CC cord-335975-m6lkrehi 34 19 the the DT cord-335975-m6lkrehi 34 20 PTPes PTPes NNP cord-335975-m6lkrehi 34 21 proportion proportion NN cord-335975-m6lkrehi 34 22 that that WDT cord-335975-m6lkrehi 34 23 was be VBD cord-335975-m6lkrehi 34 24 wasted waste VBN cord-335975-m6lkrehi 34 25 in in IN cord-335975-m6lkrehi 34 26 ineffective ineffective JJ cord-335975-m6lkrehi 34 27 efforts effort NNS cord-335975-m6lkrehi 34 28 decreased decrease VBD cord-335975-m6lkrehi 34 29 with with IN cord-335975-m6lkrehi 34 30 PAV PAV NNP cord-335975-m6lkrehi 34 31 + + CC cord-335975-m6lkrehi 34 32 ( ( -LRB- cord-335975-m6lkrehi 34 33 1 1 CD cord-335975-m6lkrehi 34 34 % % NN cord-335975-m6lkrehi 34 35 [ [ -LRB- cord-335975-m6lkrehi 34 36 1 1 CD cord-335975-m6lkrehi 34 37 ] ] -RRB- cord-335975-m6lkrehi 34 38 [ [ -LRB- cord-335975-m6lkrehi 34 39 2 2 CD cord-335975-m6lkrehi 34 40 ] ] -RRB- cord-335975-m6lkrehi 34 41 vs. vs. IN cord-335975-m6lkrehi 34 42 18 18 CD cord-335975-m6lkrehi 34 43 % % NN cord-335975-m6lkrehi 34 44 , , , cord-335975-m6lkrehi 34 45 p p NN cord-335975-m6lkrehi 34 46 = = SYM cord-335975-m6lkrehi 34 47 0.03 0.03 CD cord-335975-m6lkrehi 34 48 ) ) -RRB- cord-335975-m6lkrehi 34 49 . . . cord-335975-m6lkrehi 35 1 Conclusion conclusion NN cord-335975-m6lkrehi 35 2 : : : cord-335975-m6lkrehi 36 1 Our -PRON- PRP$ cord-335975-m6lkrehi 36 2 preliminary preliminary JJ cord-335975-m6lkrehi 36 3 data datum NNS cord-335975-m6lkrehi 36 4 suggest suggest VBP cord-335975-m6lkrehi 36 5 that that DT cord-335975-m6lkrehi 36 6 : : : cord-335975-m6lkrehi 36 7 ( ( -LRB- cord-335975-m6lkrehi 36 8 1 1 LS cord-335975-m6lkrehi 36 9 ) ) -RRB- cord-335975-m6lkrehi 36 10 PAV pav NN cord-335975-m6lkrehi 36 11 + + CC cord-335975-m6lkrehi 36 12 reduces reduce VBZ cord-335975-m6lkrehi 36 13 the the DT cord-335975-m6lkrehi 36 14 incidence incidence NN cord-335975-m6lkrehi 36 15 of of IN cord-335975-m6lkrehi 36 16 refractory refractory JJ cord-335975-m6lkrehi 36 17 ineffective ineffective JJ cord-335975-m6lkrehi 36 18 triggering triggering NN cord-335975-m6lkrehi 36 19 ; ; : cord-335975-m6lkrehi 36 20 ( ( -LRB- cord-335975-m6lkrehi 36 21 2 2 LS cord-335975-m6lkrehi 36 22 ) ) -RRB- cord-335975-m6lkrehi 36 23 patients patient NNS cord-335975-m6lkrehi 36 24 exposed expose VBN cord-335975-m6lkrehi 36 25 to to IN cord-335975-m6lkrehi 36 26 refractory refractory JJ cord-335975-m6lkrehi 36 27 ineffective ineffective JJ cord-335975-m6lkrehi 36 28 triggering triggering NN cord-335975-m6lkrehi 36 29 during during IN cord-335975-m6lkrehi 36 30 PSV PSV NNP cord-335975-m6lkrehi 36 31 seem seem VBP cord-335975-m6lkrehi 36 32 characterized characterize VBN cord-335975-m6lkrehi 36 33 by by IN cord-335975-m6lkrehi 36 34 rapid rapid JJ cord-335975-m6lkrehi 36 35 shallow shallow JJ cord-335975-m6lkrehi 36 36 breathing breathing NN cord-335975-m6lkrehi 36 37 despite despite IN cord-335975-m6lkrehi 36 38 high high JJ cord-335975-m6lkrehi 36 39 ventilatory ventilatory NN cord-335975-m6lkrehi 36 40 support support NN cord-335975-m6lkrehi 36 41 , , , cord-335975-m6lkrehi 36 42 questioning question VBG cord-335975-m6lkrehi 36 43 the the DT cord-335975-m6lkrehi 36 44 tolerance tolerance NN cord-335975-m6lkrehi 36 45 of of IN cord-335975-m6lkrehi 36 46 both both DT cord-335975-m6lkrehi 36 47 ventilatory ventilatory JJ cord-335975-m6lkrehi 36 48 modes mode NNS cord-335975-m6lkrehi 36 49 . . . cord-335975-m6lkrehi 37 1 Results result NNS cord-335975-m6lkrehi 37 2 with with IN cord-335975-m6lkrehi 37 3 further further JJ cord-335975-m6lkrehi 37 4 inclusions inclusion NNS cord-335975-m6lkrehi 37 5 will will MD cord-335975-m6lkrehi 37 6 be be VB cord-335975-m6lkrehi 37 7 presented present VBN cord-335975-m6lkrehi 37 8 . . . cord-335975-m6lkrehi 38 1 Introduction introduction NN cord-335975-m6lkrehi 38 2 : : : cord-335975-m6lkrehi 39 1 The the DT cord-335975-m6lkrehi 39 2 use use NN cord-335975-m6lkrehi 39 3 of of IN cord-335975-m6lkrehi 39 4 alternatives alternative NNS cord-335975-m6lkrehi 39 5 to to IN cord-335975-m6lkrehi 39 6 carbapenems carbapenem NNS cord-335975-m6lkrehi 39 7 to to TO cord-335975-m6lkrehi 39 8 treat treat VB cord-335975-m6lkrehi 39 9 patients patient NNS cord-335975-m6lkrehi 39 10 with with IN cord-335975-m6lkrehi 39 11 extended extend VBN cord-335975-m6lkrehi 39 12 - - HYPH cord-335975-m6lkrehi 39 13 spectrum spectrum NN cord-335975-m6lkrehi 39 14 beta beta NN cord-335975-m6lkrehi 39 15 lactamase lactamase NN cord-335975-m6lkrehi 39 16 - - HYPH cord-335975-m6lkrehi 39 17 producing produce VBG cord-335975-m6lkrehi 39 18 Gram Gram NNP cord-335975-m6lkrehi 39 19 negative negative JJ cord-335975-m6lkrehi 39 20 bacilli bacilli NN cord-335975-m6lkrehi 39 21 ( ( -LRB- cord-335975-m6lkrehi 39 22 ESBL ESBL NNP cord-335975-m6lkrehi 39 23 - - HYPH cord-335975-m6lkrehi 39 24 GNB GNB NNP cord-335975-m6lkrehi 39 25 ) ) -RRB- cord-335975-m6lkrehi 40 1 infections infection NNS cord-335975-m6lkrehi 40 2 remains remain VBZ cord-335975-m6lkrehi 40 3 controversial controversial JJ cord-335975-m6lkrehi 40 4 . . . cord-335975-m6lkrehi 41 1 Their -PRON- PRP$ cord-335975-m6lkrehi 41 2 use use NN cord-335975-m6lkrehi 41 3 in in IN cord-335975-m6lkrehi 41 4 patients patient NNS cord-335975-m6lkrehi 41 5 with with IN cord-335975-m6lkrehi 41 6 severe severe JJ cord-335975-m6lkrehi 41 7 infections infection NNS cord-335975-m6lkrehi 41 8 in in IN cord-335975-m6lkrehi 41 9 the the DT cord-335975-m6lkrehi 41 10 ICU ICU NNP cord-335975-m6lkrehi 41 11 has have VBZ cord-335975-m6lkrehi 41 12 been be VBN cord-335975-m6lkrehi 41 13 poorly poorly RB cord-335975-m6lkrehi 41 14 studied study VBN cord-335975-m6lkrehi 41 15 . . . cord-335975-m6lkrehi 42 1 The the DT cord-335975-m6lkrehi 42 2 aim aim NN cord-335975-m6lkrehi 42 3 of of IN cord-335975-m6lkrehi 42 4 this this DT cord-335975-m6lkrehi 42 5 study study NN cord-335975-m6lkrehi 42 6 was be VBD cord-335975-m6lkrehi 42 7 to to TO cord-335975-m6lkrehi 42 8 compare compare VB cord-335975-m6lkrehi 42 9 the the DT cord-335975-m6lkrehi 42 10 outcome outcome NN cord-335975-m6lkrehi 42 11 of of IN cord-335975-m6lkrehi 42 12 ICU ICU NNP cord-335975-m6lkrehi 42 13 patients patient NNS cord-335975-m6lkrehi 42 14 having have VBG cord-335975-m6lkrehi 42 15 received receive VBN cord-335975-m6lkrehi 42 16 carbapenems carbapenem NNS cord-335975-m6lkrehi 42 17 to to IN cord-335975-m6lkrehi 42 18 those those DT cord-335975-m6lkrehi 42 19 having have VBG cord-335975-m6lkrehi 42 20 received receive VBN cord-335975-m6lkrehi 42 21 a a DT cord-335975-m6lkrehi 42 22 carbapenem carbapenem NN cord-335975-m6lkrehi 42 23 - - HYPH cord-335975-m6lkrehi 42 24 sparing spare VBG cord-335975-m6lkrehi 42 25 agent agent NN cord-335975-m6lkrehi 42 26 ( ( -LRB- cord-335975-m6lkrehi 42 27 CSA CSA NNP cord-335975-m6lkrehi 42 28 ) ) -RRB- cord-335975-m6lkrehi 42 29 . . . cord-335975-m6lkrehi 43 1 The the DT cord-335975-m6lkrehi 43 2 charts chart NNS cord-335975-m6lkrehi 43 3 of of IN cord-335975-m6lkrehi 43 4 patients patient NNS cord-335975-m6lkrehi 43 5 with with IN cord-335975-m6lkrehi 43 6 ESBL ESBL NNP cord-335975-m6lkrehi 43 7 - - HYPH cord-335975-m6lkrehi 43 8 GNB GNB NNP cord-335975-m6lkrehi 43 9 infection infection NN cord-335975-m6lkrehi 43 10 hospitalized hospitalize VBN cord-335975-m6lkrehi 43 11 in in IN cord-335975-m6lkrehi 43 12 our -PRON- PRP$ cord-335975-m6lkrehi 43 13 ICU ICU NNP cord-335975-m6lkrehi 43 14 between between IN cord-335975-m6lkrehi 43 15 2015 2015 CD cord-335975-m6lkrehi 43 16 and and CC cord-335975-m6lkrehi 43 17 2017 2017 CD cord-335975-m6lkrehi 43 18 were be VBD cord-335975-m6lkrehi 43 19 retrospectively retrospectively RB cord-335975-m6lkrehi 43 20 reviewed review VBN cord-335975-m6lkrehi 43 21 . . . cord-335975-m6lkrehi 44 1 Patients patient NNS cord-335975-m6lkrehi 44 2 treated treat VBN cord-335975-m6lkrehi 44 3 with with IN cord-335975-m6lkrehi 44 4 betalactam betalactam NNP cord-335975-m6lkrehi 44 5 betalactam betalactam NNP cord-335975-m6lkrehi 44 6 inhibitor inhibitor NN cord-335975-m6lkrehi 44 7 ( ( -LRB- cord-335975-m6lkrehi 44 8 BL BL NNP cord-335975-m6lkrehi 44 9 BLI BLI NNP cord-335975-m6lkrehi 44 10 ) ) -RRB- cord-335975-m6lkrehi 44 11 , , , cord-335975-m6lkrehi 44 12 cefepime cefepime NNP cord-335975-m6lkrehi 44 13 or or CC cord-335975-m6lkrehi 44 14 quinolones quinolones NNP cord-335975-m6lkrehi 44 15 were be VBD cord-335975-m6lkrehi 44 16 considered consider VBN cord-335975-m6lkrehi 44 17 has have VBZ cord-335975-m6lkrehi 44 18 having have VBG cord-335975-m6lkrehi 44 19 received receive VBN cord-335975-m6lkrehi 44 20 an an DT cord-335975-m6lkrehi 44 21 alternative alternative NN cord-335975-m6lkrehi 44 22 to to IN cord-335975-m6lkrehi 44 23 carbapenems carbapenem NNS cord-335975-m6lkrehi 44 24 ( ( -LRB- cord-335975-m6lkrehi 44 25 CSA CSA NNP cord-335975-m6lkrehi 44 26 ) ) -RRB- cord-335975-m6lkrehi 44 27 . . . cord-335975-m6lkrehi 45 1 Patients patient NNS cord-335975-m6lkrehi 45 2 having have VBG cord-335975-m6lkrehi 45 3 received receive VBN cord-335975-m6lkrehi 45 4 such such PDT cord-335975-m6lkrehi 45 5 a a DT cord-335975-m6lkrehi 45 6 CSA CSA NNP cord-335975-m6lkrehi 45 7 were be VBD cord-335975-m6lkrehi 45 8 compared compare VBN cord-335975-m6lkrehi 45 9 to to IN cord-335975-m6lkrehi 45 10 those those DT cord-335975-m6lkrehi 45 11 having have VBG cord-335975-m6lkrehi 45 12 received receive VBN cord-335975-m6lkrehi 45 13 a a DT cord-335975-m6lkrehi 45 14 carbapenems carbapenem NNS cord-335975-m6lkrehi 45 15 . . . cord-335975-m6lkrehi 46 1 Primary primary JJ cord-335975-m6lkrehi 46 2 outcome outcome NN cord-335975-m6lkrehi 46 3 was be VBD cord-335975-m6lkrehi 46 4 treatment treatment NN cord-335975-m6lkrehi 46 5 failure failure NN cord-335975-m6lkrehi 46 6 at at IN cord-335975-m6lkrehi 46 7 day day NN cord-335975-m6lkrehi 46 8 28 28 CD cord-335975-m6lkrehi 46 9 , , , cord-335975-m6lkrehi 46 10 defined define VBN cord-335975-m6lkrehi 46 11 as as IN cord-335975-m6lkrehi 46 12 ESBL ESBL NNP cord-335975-m6lkrehi 46 13 - - HYPH cord-335975-m6lkrehi 46 14 GNB GNB NNP cord-335975-m6lkrehi 46 15 infection infection NN cord-335975-m6lkrehi 46 16 recurrence recurrence NN cord-335975-m6lkrehi 46 17 ( ( -LRB- cord-335975-m6lkrehi 46 18 relapse relapse NN cord-335975-m6lkrehi 46 19 with with IN cord-335975-m6lkrehi 46 20 same same JJ cord-335975-m6lkrehi 46 21 pathogen pathogen NN cord-335975-m6lkrehi 46 22 ) ) -RRB- cord-335975-m6lkrehi 46 23 or or CC cord-335975-m6lkrehi 46 24 death death NN cord-335975-m6lkrehi 46 25 , , , cord-335975-m6lkrehi 46 26 whichever whichever WDT cord-335975-m6lkrehi 46 27 first first RB cord-335975-m6lkrehi 46 28 occurred occur VBD cord-335975-m6lkrehi 46 29 . . . cord-335975-m6lkrehi 47 1 Results result NNS cord-335975-m6lkrehi 47 2 : : : cord-335975-m6lkrehi 47 3 66 66 CD cord-335975-m6lkrehi 47 4 patients patient NNS cord-335975-m6lkrehi 47 5 with with IN cord-335975-m6lkrehi 47 6 ESBL ESBL NNP cord-335975-m6lkrehi 47 7 - - HYPH cord-335975-m6lkrehi 47 8 GNB GNB NNP cord-335975-m6lkrehi 47 9 infection infection NN cord-335975-m6lkrehi 47 10 were be VBD cord-335975-m6lkrehi 47 11 included include VBN cord-335975-m6lkrehi 47 12 . . . cord-335975-m6lkrehi 48 1 Source source NN cord-335975-m6lkrehi 48 2 of of IN cord-335975-m6lkrehi 48 3 infection infection NN cord-335975-m6lkrehi 48 4 was be VBD cord-335975-m6lkrehi 48 5 the the DT cord-335975-m6lkrehi 48 6 lung lung NN cord-335975-m6lkrehi 48 7 for for IN cord-335975-m6lkrehi 48 8 most most JJS cord-335975-m6lkrehi 48 9 of of IN cord-335975-m6lkrehi 48 10 them -PRON- PRP cord-335975-m6lkrehi 48 11 . . . cord-335975-m6lkrehi 49 1 Characteristics characteristic NNS cord-335975-m6lkrehi 49 2 of of IN cord-335975-m6lkrehi 49 3 patients patient NNS cord-335975-m6lkrehi 49 4 are be VBP cord-335975-m6lkrehi 49 5 displayed display VBN cord-335975-m6lkrehi 49 6 on on IN cord-335975-m6lkrehi 49 7 Table Table NNP cord-335975-m6lkrehi 49 8 1 1 CD cord-335975-m6lkrehi 49 9 . . . cord-335975-m6lkrehi 50 1 Their -PRON- PRP$ cord-335975-m6lkrehi 50 2 median median JJ cord-335975-m6lkrehi 50 3 SAPS SAPS NNP cord-335975-m6lkrehi 50 4 II II NNP cord-335975-m6lkrehi 50 5 and and CC cord-335975-m6lkrehi 50 6 SOFA sofa NN cord-335975-m6lkrehi 50 7 scores score NNS cord-335975-m6lkrehi 50 8 were be VBD cord-335975-m6lkrehi 50 9 59 59 CD cord-335975-m6lkrehi 50 10 and and CC cord-335975-m6lkrehi 50 11 12 12 CD cord-335975-m6lkrehi 50 12 [ [ -LRB- cord-335975-m6lkrehi 50 13 7 7 CD cord-335975-m6lkrehi 50 14 ] ] -RRB- cord-335975-m6lkrehi 50 15 [ [ -LRB- cord-335975-m6lkrehi 50 16 8 8 CD cord-335975-m6lkrehi 50 17 ] ] -RRB- cord-335975-m6lkrehi 50 18 [ [ -LRB- cord-335975-m6lkrehi 50 19 9 9 CD cord-335975-m6lkrehi 50 20 ] ] -RRB- cord-335975-m6lkrehi 50 21 [ [ -LRB- cord-335975-m6lkrehi 50 22 10 10 CD cord-335975-m6lkrehi 50 23 ] ] -RRB- cord-335975-m6lkrehi 50 24 [ [ -LRB- cord-335975-m6lkrehi 50 25 11 11 CD cord-335975-m6lkrehi 50 26 ] ] -RRB- cord-335975-m6lkrehi 50 27 [ [ -LRB- cord-335975-m6lkrehi 50 28 12 12 CD cord-335975-m6lkrehi 50 29 ] ] -RRB- cord-335975-m6lkrehi 50 30 [ [ -LRB- cord-335975-m6lkrehi 50 31 13 13 CD cord-335975-m6lkrehi 50 32 ] ] -RRB- cord-335975-m6lkrehi 50 33 [ [ -LRB- cord-335975-m6lkrehi 50 34 14 14 CD cord-335975-m6lkrehi 50 35 ] ] -RRB- cord-335975-m6lkrehi 50 36 [ [ -LRB- cord-335975-m6lkrehi 50 37 15 15 CD cord-335975-m6lkrehi 50 38 ] ] -RRB- cord-335975-m6lkrehi 50 39 , , , cord-335975-m6lkrehi 50 40 respectively respectively RB cord-335975-m6lkrehi 50 41 , , , cord-335975-m6lkrehi 50 42 and and CC cord-335975-m6lkrehi 50 43 38 38 CD cord-335975-m6lkrehi 50 44 ( ( -LRB- cord-335975-m6lkrehi 50 45 58 58 CD cord-335975-m6lkrehi 50 46 % % NN cord-335975-m6lkrehi 50 47 ) ) -RRB- cord-335975-m6lkrehi 50 48 were be VBD cord-335975-m6lkrehi 50 49 on on IN cord-335975-m6lkrehi 50 50 septic septic JJ cord-335975-m6lkrehi 50 51 shock shock NN cord-335975-m6lkrehi 50 52 . . . cord-335975-m6lkrehi 51 1 40 40 CD cord-335975-m6lkrehi 51 2 patients patient NNS cord-335975-m6lkrehi 51 3 received receive VBD cord-335975-m6lkrehi 51 4 a a DT cord-335975-m6lkrehi 51 5 carbapenem carbapenem NN cord-335975-m6lkrehi 51 6 empirically empirically RB cord-335975-m6lkrehi 51 7 , , , cord-335975-m6lkrehi 51 8 among among IN cord-335975-m6lkrehi 51 9 whom whom WP cord-335975-m6lkrehi 51 10 18 18 CD cord-335975-m6lkrehi 51 11 were be VBD cord-335975-m6lkrehi 51 12 switched switch VBN cord-335975-m6lkrehi 51 13 to to IN cord-335975-m6lkrehi 51 14 a a DT cord-335975-m6lkrehi 51 15 CSA CSA NNP cord-335975-m6lkrehi 51 16 agent agent NN cord-335975-m6lkrehi 51 17 when when WRB cord-335975-m6lkrehi 51 18 antibiogram antibiogram NNP cord-335975-m6lkrehi 51 19 was be VBD cord-335975-m6lkrehi 51 20 available available JJ cord-335975-m6lkrehi 52 1 ( ( -LRB- cord-335975-m6lkrehi 52 2 CSA CSA NNP cord-335975-m6lkrehi 52 3 - - HYPH cord-335975-m6lkrehi 52 4 definite definite JJ cord-335975-m6lkrehi 52 5 group group NN cord-335975-m6lkrehi 52 6 ) ) -RRB- cord-335975-m6lkrehi 52 7 , , , cord-335975-m6lkrehi 52 8 whereas whereas IN cord-335975-m6lkrehi 52 9 carbapenems carbapenem NNS cord-335975-m6lkrehi 52 10 were be VBD cord-335975-m6lkrehi 52 11 pursued pursue VBN cord-335975-m6lkrehi 52 12 in in IN cord-335975-m6lkrehi 52 13 the the DT cord-335975-m6lkrehi 52 14 22 22 CD cord-335975-m6lkrehi 52 15 others other NNS cord-335975-m6lkrehi 52 16 ( ( -LRB- cord-335975-m6lkrehi 52 17 carbapenem carbapenem NN cord-335975-m6lkrehi 52 18 - - HYPH cord-335975-m6lkrehi 52 19 only only RB cord-335975-m6lkrehi 52 20 group group NN cord-335975-m6lkrehi 52 21 ) ) -RRB- cord-335975-m6lkrehi 52 22 , , , cord-335975-m6lkrehi 52 23 mainly mainly RB cord-335975-m6lkrehi 52 24 because because IN cord-335975-m6lkrehi 52 25 pathogens pathogen NNS cord-335975-m6lkrehi 52 26 were be VBD cord-335975-m6lkrehi 52 27 resistant resistant JJ cord-335975-m6lkrehi 52 28 to to IN cord-335975-m6lkrehi 52 29 others other NNS cord-335975-m6lkrehi 52 30 antibiotics antibiotic NNS cord-335975-m6lkrehi 52 31 . . . cord-335975-m6lkrehi 53 1 Among among IN cord-335975-m6lkrehi 53 2 the the DT cord-335975-m6lkrehi 53 3 26 26 CD cord-335975-m6lkrehi 53 4 patients patient NNS cord-335975-m6lkrehi 53 5 having have VBG cord-335975-m6lkrehi 53 6 received receive VBN cord-335975-m6lkrehi 53 7 a a DT cord-335975-m6lkrehi 53 8 non non JJ cord-335975-m6lkrehi 53 9 - - JJ cord-335975-m6lkrehi 53 10 carbapenem carbapenem JJ cord-335975-m6lkrehi 53 11 agent agent NN cord-335975-m6lkrehi 53 12 as as IN cord-335975-m6lkrehi 53 13 empirical empirical JJ cord-335975-m6lkrehi 53 14 treatment treatment NN cord-335975-m6lkrehi 53 15 , , , cord-335975-m6lkrehi 53 16 pathogen pathogen NN cord-335975-m6lkrehi 53 17 was be VBD cord-335975-m6lkrehi 53 18 susceptible susceptible JJ cord-335975-m6lkrehi 53 19 to to IN cord-335975-m6lkrehi 53 20 this this DT cord-335975-m6lkrehi 53 21 agent agent NN cord-335975-m6lkrehi 53 22 in in IN cord-335975-m6lkrehi 53 23 9 9 CD cord-335975-m6lkrehi 53 24 and and CC cord-335975-m6lkrehi 53 25 they -PRON- PRP cord-335975-m6lkrehi 53 26 pursued pursue VBD cord-335975-m6lkrehi 53 27 the the DT cord-335975-m6lkrehi 53 28 same same JJ cord-335975-m6lkrehi 53 29 treatment treatment NN cord-335975-m6lkrehi 53 30 ( ( -LRB- cord-335975-m6lkrehi 53 31 CSA CSA NNP cord-335975-m6lkrehi 53 32 - - HYPH cord-335975-m6lkrehi 53 33 only only RB cord-335975-m6lkrehi 53 34 group group NN cord-335975-m6lkrehi 53 35 ) ) -RRB- cord-335975-m6lkrehi 53 36 , , , cord-335975-m6lkrehi 53 37 whereas whereas IN cord-335975-m6lkrehi 53 38 17 17 CD cord-335975-m6lkrehi 53 39 were be VBD cord-335975-m6lkrehi 53 40 switched switch VBN cord-335975-m6lkrehi 53 41 to to IN cord-335975-m6lkrehi 53 42 a a DT cord-335975-m6lkrehi 53 43 carbapenem carbapenem NN cord-335975-m6lkrehi 53 44 ( ( -LRB- cord-335975-m6lkrehi 53 45 pathogens pathogen NNS cord-335975-m6lkrehi 53 46 resistant resistant JJ cord-335975-m6lkrehi 53 47 to to IN cord-335975-m6lkrehi 53 48 empirical empirical JJ cord-335975-m6lkrehi 53 49 treatment treatment NN cord-335975-m6lkrehi 53 50 , , , cord-335975-m6lkrehi 53 51 carbapenem carbapenem JJ cord-335975-m6lkrehi 53 52 - - HYPH cord-335975-m6lkrehi 53 53 definite definite JJ cord-335975-m6lkrehi 53 54 group group NN cord-335975-m6lkrehi 53 55 ) ) -RRB- cord-335975-m6lkrehi 53 56 . . . cord-335975-m6lkrehi 54 1 Treatment treatment NN cord-335975-m6lkrehi 54 2 failure failure NN cord-335975-m6lkrehi 54 3 were be VBD cord-335975-m6lkrehi 54 4 not not RB cord-335975-m6lkrehi 54 5 different different JJ cord-335975-m6lkrehi 54 6 among among IN cord-335975-m6lkrehi 54 7 these these DT cord-335975-m6lkrehi 54 8 4 4 CD cord-335975-m6lkrehi 54 9 groups group NNS cord-335975-m6lkrehi 54 10 ( ( -LRB- cord-335975-m6lkrehi 54 11 Table table NN cord-335975-m6lkrehi 54 12 1 1 CD cord-335975-m6lkrehi 54 13 ) ) -RRB- cord-335975-m6lkrehi 54 14 . . . cord-335975-m6lkrehi 55 1 Globally globally RB cord-335975-m6lkrehi 55 2 , , , cord-335975-m6lkrehi 55 3 27 27 CD cord-335975-m6lkrehi 55 4 patients patient NNS cord-335975-m6lkrehi 55 5 received receive VBD cord-335975-m6lkrehi 55 6 a a DT cord-335975-m6lkrehi 55 7 CSA CSA NNP cord-335975-m6lkrehi 55 8 as as IN cord-335975-m6lkrehi 55 9 their -PRON- PRP$ cord-335975-m6lkrehi 55 10 definite definite JJ cord-335975-m6lkrehi 55 11 treatment treatment NN cord-335975-m6lkrehi 55 12 ( ( -LRB- cord-335975-m6lkrehi 55 13 CSAdefinite CSAdefinite NNP cord-335975-m6lkrehi 55 14 and and CC cord-335975-m6lkrehi 55 15 CSA CSA NNP cord-335975-m6lkrehi 55 16 - - HYPH cord-335975-m6lkrehi 55 17 only only RB cord-335975-m6lkrehi 55 18 groups group NNS cord-335975-m6lkrehi 55 19 ) ) -RRB- cord-335975-m6lkrehi 55 20 , , , cord-335975-m6lkrehi 55 21 whereas whereas IN cord-335975-m6lkrehi 55 22 39 39 CD cord-335975-m6lkrehi 55 23 received receive VBD cord-335975-m6lkrehi 55 24 a a DT cord-335975-m6lkrehi 55 25 carbapenems carbapenem NNS cord-335975-m6lkrehi 55 26 ( ( -LRB- cord-335975-m6lkrehi 55 27 carbapenems carbapenem NNS cord-335975-m6lkrehi 55 28 - - : cord-335975-m6lkrehi 55 29 only only RB cord-335975-m6lkrehi 55 30 and and CC cord-335975-m6lkrehi 55 31 carbapenems carbapenem NNS cord-335975-m6lkrehi 55 32 - - HYPH cord-335975-m6lkrehi 55 33 definite definite JJ cord-335975-m6lkrehi 55 34 groups group NNS cord-335975-m6lkrehi 55 35 ) ) -RRB- cord-335975-m6lkrehi 55 36 . . . cord-335975-m6lkrehi 56 1 Whereas whereas IN cord-335975-m6lkrehi 56 2 duration duration NN cord-335975-m6lkrehi 56 3 of of IN cord-335975-m6lkrehi 56 4 antimicrobial antimicrobial JJ cord-335975-m6lkrehi 56 5 treatment treatment NN cord-335975-m6lkrehi 56 6 was be VBD cord-335975-m6lkrehi 56 7 similar similar JJ cord-335975-m6lkrehi 56 8 ( ( -LRB- cord-335975-m6lkrehi 56 9 8 8 CD cord-335975-m6lkrehi 56 10 [ [ -LRB- cord-335975-m6lkrehi 56 11 6 6 CD cord-335975-m6lkrehi 56 12 - - SYM cord-335975-m6lkrehi 56 13 10 10 CD cord-335975-m6lkrehi 56 14 ] ] -RRB- cord-335975-m6lkrehi 56 15 days day NNS cord-335975-m6lkrehi 56 16 vs. vs. FW cord-335975-m6lkrehi 56 17 9 9 CD cord-335975-m6lkrehi 56 18 [ [ -LRB- cord-335975-m6lkrehi 56 19 7 7 CD cord-335975-m6lkrehi 56 20 - - SYM cord-335975-m6lkrehi 56 21 10 10 CD cord-335975-m6lkrehi 56 22 ] ] -RRB- cord-335975-m6lkrehi 56 23 days day NNS cord-335975-m6lkrehi 56 24 , , , cord-335975-m6lkrehi 56 25 respectively respectively RB cord-335975-m6lkrehi 56 26 , , , cord-335975-m6lkrehi 56 27 p p NN cord-335975-m6lkrehi 56 28 = = SYM cord-335975-m6lkrehi 56 29 NS NS NNP cord-335975-m6lkrehi 56 30 ) ) -RRB- cord-335975-m6lkrehi 56 31 , , , cord-335975-m6lkrehi 56 32 treatment treatment NN cord-335975-m6lkrehi 56 33 failure failure NN cord-335975-m6lkrehi 56 34 rate rate NN cord-335975-m6lkrehi 56 35 was be VBD cord-335975-m6lkrehi 56 36 not not RB cord-335975-m6lkrehi 56 37 higher high JJR cord-335975-m6lkrehi 56 38 in in IN cord-335975-m6lkrehi 56 39 the the DT cord-335975-m6lkrehi 56 40 former former JJ cord-335975-m6lkrehi 56 41 , , , cord-335975-m6lkrehi 56 42 as as IN cord-335975-m6lkrehi 56 43 compared compare VBN cord-335975-m6lkrehi 56 44 to to IN cord-335975-m6lkrehi 56 45 those those DT cord-335975-m6lkrehi 56 46 having have VBG cord-335975-m6lkrehi 56 47 received receive VBN cord-335975-m6lkrehi 56 48 a a DT cord-335975-m6lkrehi 56 49 carbapenems carbapenem NNS cord-335975-m6lkrehi 56 50 ( ( -LRB- cord-335975-m6lkrehi 56 51 29 29 CD cord-335975-m6lkrehi 56 52 vs. vs. NN cord-335975-m6lkrehi 56 53 71 71 CD cord-335975-m6lkrehi 56 54 % % NN cord-335975-m6lkrehi 56 55 , , , cord-335975-m6lkrehi 56 56 respectively respectively RB cord-335975-m6lkrehi 56 57 , , , cord-335975-m6lkrehi 56 58 p p NN cord-335975-m6lkrehi 56 59 = = SYM cord-335975-m6lkrehi 56 60 0.049 0.049 CD cord-335975-m6lkrehi 56 61 ) ) -RRB- cord-335975-m6lkrehi 56 62 . . . cord-335975-m6lkrehi 57 1 Conclusion conclusion NN cord-335975-m6lkrehi 57 2 : : : cord-335975-m6lkrehi 57 3 Treatment treatment NN cord-335975-m6lkrehi 57 4 of of IN cord-335975-m6lkrehi 57 5 patients patient NNS cord-335975-m6lkrehi 57 6 with with IN cord-335975-m6lkrehi 57 7 ESBL ESBL NNP cord-335975-m6lkrehi 57 8 - - HYPH cord-335975-m6lkrehi 57 9 GNB GNB NNP cord-335975-m6lkrehi 57 10 severe severe JJ cord-335975-m6lkrehi 57 11 infection infection NN cord-335975-m6lkrehi 57 12 in in IN cord-335975-m6lkrehi 57 13 the the DT cord-335975-m6lkrehi 57 14 ICU ICU NNP cord-335975-m6lkrehi 57 15 with with IN cord-335975-m6lkrehi 57 16 a a DT cord-335975-m6lkrehi 57 17 CSA CSA NNP cord-335975-m6lkrehi 57 18 seems seem VBZ cord-335975-m6lkrehi 57 19 to to TO cord-335975-m6lkrehi 57 20 be be VB cord-335975-m6lkrehi 57 21 safe safe JJ cord-335975-m6lkrehi 57 22 when when WRB cord-335975-m6lkrehi 57 23 the the DT cord-335975-m6lkrehi 57 24 pathogen pathogen NN cord-335975-m6lkrehi 57 25 is be VBZ cord-335975-m6lkrehi 57 26 susceptible susceptible JJ cord-335975-m6lkrehi 57 27 to to IN cord-335975-m6lkrehi 57 28 this this DT cord-335975-m6lkrehi 57 29 CSA CSA NNP cord-335975-m6lkrehi 57 30 . . . cord-335975-m6lkrehi 58 1 However however RB cord-335975-m6lkrehi 58 2 , , , cord-335975-m6lkrehi 58 3 MIC MIC NNP cord-335975-m6lkrehi 58 4 should should MD cord-335975-m6lkrehi 58 5 be be VB cord-335975-m6lkrehi 58 6 first first RB cord-335975-m6lkrehi 58 7 determined determine VBN cord-335975-m6lkrehi 58 8 before before IN cord-335975-m6lkrehi 58 9 de de NN cord-335975-m6lkrehi 58 10 - - NN cord-335975-m6lkrehi 58 11 escalating escalate VBG cord-335975-m6lkrehi 58 12 to to IN cord-335975-m6lkrehi 58 13 a a DT cord-335975-m6lkrehi 58 14 CSA CSA NNP cord-335975-m6lkrehi 58 15 . . . cord-335975-m6lkrehi 59 1 Larger large JJR cord-335975-m6lkrehi 59 2 studies study NNS cord-335975-m6lkrehi 59 3 are be VBP cord-335975-m6lkrehi 59 4 needed need VBN cord-335975-m6lkrehi 59 5 . . . cord-335975-m6lkrehi 60 1 1 1 CD cord-335975-m6lkrehi 60 2 Percentages percentage NNS cord-335975-m6lkrehi 60 3 of of IN cord-335975-m6lkrehi 60 4 samplings sampling NNS cord-335975-m6lkrehi 60 5 which which WDT cord-335975-m6lkrehi 60 6 attained attain VBD cord-335975-m6lkrehi 60 7 the the DT cord-335975-m6lkrehi 60 8 PK PK NNP cord-335975-m6lkrehi 60 9 PD PD NNP cord-335975-m6lkrehi 60 10 targets target NNS cord-335975-m6lkrehi 60 11 for for IN cord-335975-m6lkrehi 60 12 various various JJ cord-335975-m6lkrehi 60 13 CrCL crcl NN cord-335975-m6lkrehi 60 14 with with IN cord-335975-m6lkrehi 60 15 potential potential JJ cord-335975-m6lkrehi 60 16 suboptimal suboptimal JJ cord-335975-m6lkrehi 60 17 beta beta NN cord-335975-m6lkrehi 60 18 - - HYPH cord-335975-m6lkrehi 60 19 lactam lactam NN cord-335975-m6lkrehi 60 20 concentration concentration NN cord-335975-m6lkrehi 60 21 in in IN cord-335975-m6lkrehi 60 22 critically critically RB cord-335975-m6lkrehi 60 23 - - HYPH cord-335975-m6lkrehi 60 24 ill ill JJ cord-335975-m6lkrehi 60 25 patients patient NNS cord-335975-m6lkrehi 60 26 with with IN cord-335975-m6lkrehi 60 27 AKI AKI NNP cord-335975-m6lkrehi 60 28 treated treat VBD cord-335975-m6lkrehi 60 29 either either CC cord-335975-m6lkrehi 60 30 with with IN cord-335975-m6lkrehi 60 31 an an DT cord-335975-m6lkrehi 60 32 early early JJ cord-335975-m6lkrehi 60 33 or or CC cord-335975-m6lkrehi 60 34 a a DT cord-335975-m6lkrehi 60 35 delayed delayed JJ cord-335975-m6lkrehi 60 36 RRT rrt NN cord-335975-m6lkrehi 60 37 strategy strategy NN cord-335975-m6lkrehi 60 38 . . . cord-335975-m6lkrehi 61 1 Patients patient NNS cord-335975-m6lkrehi 61 2 and and CC cord-335975-m6lkrehi 61 3 methods method NNS cord-335975-m6lkrehi 61 4 : : : cord-335975-m6lkrehi 61 5 Ancillary ancillary JJ cord-335975-m6lkrehi 61 6 study study NN cord-335975-m6lkrehi 61 7 in in IN cord-335975-m6lkrehi 61 8 a a DT cord-335975-m6lkrehi 61 9 subset subset NN cord-335975-m6lkrehi 61 10 of of IN cord-335975-m6lkrehi 61 11 patients patient NNS cord-335975-m6lkrehi 61 12 with with IN cord-335975-m6lkrehi 61 13 severe severe JJ cord-335975-m6lkrehi 61 14 AKI AKI NNP cord-335975-m6lkrehi 61 15 ( ( -LRB- cord-335975-m6lkrehi 61 16 KDIGO3 KDIGO3 NNP cord-335975-m6lkrehi 61 17 ) ) -RRB- cord-335975-m6lkrehi 61 18 , , , cord-335975-m6lkrehi 61 19 receiving receive VBG cord-335975-m6lkrehi 61 20 a a DT cord-335975-m6lkrehi 61 21 beta beta NN cord-335975-m6lkrehi 61 22 - - HYPH cord-335975-m6lkrehi 61 23 lactam lactam NNS cord-335975-m6lkrehi 61 24 antibiotic antibiotic NN cord-335975-m6lkrehi 61 25 , , , cord-335975-m6lkrehi 61 26 in in IN cord-335975-m6lkrehi 61 27 a a DT cord-335975-m6lkrehi 61 28 trial trial NN cord-335975-m6lkrehi 61 29 comparing compare VBG cord-335975-m6lkrehi 61 30 two two CD cord-335975-m6lkrehi 61 31 RRT RRT NNP cord-335975-m6lkrehi 61 32 initiation initiation NN cord-335975-m6lkrehi 61 33 strategies strategy NNS cord-335975-m6lkrehi 61 34 . . . cord-335975-m6lkrehi 62 1 In in IN cord-335975-m6lkrehi 62 2 this this DT cord-335975-m6lkrehi 62 3 trial trial NN cord-335975-m6lkrehi 62 4 , , , cord-335975-m6lkrehi 62 5 patients patient NNS cord-335975-m6lkrehi 62 6 from from IN cord-335975-m6lkrehi 62 7 31 31 CD cord-335975-m6lkrehi 62 8 intensive intensive JJ cord-335975-m6lkrehi 62 9 care care NN cord-335975-m6lkrehi 62 10 units unit NNS cord-335975-m6lkrehi 62 11 were be VBD cord-335975-m6lkrehi 62 12 randomly randomly RB cord-335975-m6lkrehi 62 13 assigned assign VBN cord-335975-m6lkrehi 62 14 to to IN cord-335975-m6lkrehi 62 15 either either CC cord-335975-m6lkrehi 62 16 an an DT cord-335975-m6lkrehi 62 17 early early JJ cord-335975-m6lkrehi 62 18 ( ( -LRB- cord-335975-m6lkrehi 62 19 immediate immediate JJ cord-335975-m6lkrehi 62 20 RRT RRT NNP cord-335975-m6lkrehi 62 21 ) ) -RRB- cord-335975-m6lkrehi 62 22 or or CC cord-335975-m6lkrehi 62 23 a a DT cord-335975-m6lkrehi 62 24 delayed delay VBN cord-335975-m6lkrehi 62 25 ( ( -LRB- cord-335975-m6lkrehi 62 26 late late JJ cord-335975-m6lkrehi 62 27 or or CC cord-335975-m6lkrehi 62 28 no no DT cord-335975-m6lkrehi 62 29 RRT rrt NN cord-335975-m6lkrehi 62 30 ) ) -RRB- cord-335975-m6lkrehi 62 31 RRT rrt NN cord-335975-m6lkrehi 62 32 initiation initiation NN cord-335975-m6lkrehi 62 33 strategy strategy NN cord-335975-m6lkrehi 62 34 . . . cord-335975-m6lkrehi 63 1 Beta beta JJ cord-335975-m6lkrehi 63 2 - - HYPH cord-335975-m6lkrehi 63 3 lactam lactam NN cord-335975-m6lkrehi 63 4 residual residual JJ cord-335975-m6lkrehi 63 5 concentrations concentration NNS cord-335975-m6lkrehi 63 6 were be VBD cord-335975-m6lkrehi 63 7 sampled sample VBN cord-335975-m6lkrehi 63 8 at at IN cord-335975-m6lkrehi 63 9 24 24 CD cord-335975-m6lkrehi 63 10 and and CC cord-335975-m6lkrehi 63 11 48 48 CD cord-335975-m6lkrehi 63 12 h h NN cord-335975-m6lkrehi 63 13 after after IN cord-335975-m6lkrehi 63 14 inclusion inclusion NN cord-335975-m6lkrehi 63 15 . . . cord-335975-m6lkrehi 64 1 The the DT cord-335975-m6lkrehi 64 2 appropriate appropriate JJ cord-335975-m6lkrehi 64 3 concentration concentration NN cord-335975-m6lkrehi 64 4 was be VBD cord-335975-m6lkrehi 64 5 defined define VBN cord-335975-m6lkrehi 64 6 as as IN cord-335975-m6lkrehi 64 7 a a DT cord-335975-m6lkrehi 64 8 trough trough NN cord-335975-m6lkrehi 64 9 of of IN cord-335975-m6lkrehi 64 10 at at RB cord-335975-m6lkrehi 64 11 least least JJS cord-335975-m6lkrehi 64 12 4 4 CD cord-335975-m6lkrehi 64 13 times time NNS cord-335975-m6lkrehi 64 14 the the DT cord-335975-m6lkrehi 64 15 minimal minimal JJ cord-335975-m6lkrehi 64 16 inhibitory inhibitory JJ cord-335975-m6lkrehi 64 17 concentration concentration NN cord-335975-m6lkrehi 64 18 ( ( -LRB- cord-335975-m6lkrehi 64 19 clinical clinical JJ cord-335975-m6lkrehi 64 20 breakpoint breakpoint NN cord-335975-m6lkrehi 64 21 of of IN cord-335975-m6lkrehi 64 22 EUCAST EUCAST NNP cord-335975-m6lkrehi 64 23 ) ) -RRB- cord-335975-m6lkrehi 64 24 . . . cord-335975-m6lkrehi 65 1 The the DT cord-335975-m6lkrehi 65 2 primary primary JJ cord-335975-m6lkrehi 65 3 outcome outcome NN cord-335975-m6lkrehi 65 4 was be VBD cord-335975-m6lkrehi 65 5 an an DT cord-335975-m6lkrehi 65 6 adequate adequate JJ cord-335975-m6lkrehi 65 7 plasma plasma NN cord-335975-m6lkrehi 65 8 concentration concentration NN cord-335975-m6lkrehi 65 9 of of IN cord-335975-m6lkrehi 65 10 the the DT cord-335975-m6lkrehi 65 11 beta beta NN cord-335975-m6lkrehi 65 12 - - HYPH cord-335975-m6lkrehi 65 13 lactam lactam NNS cord-335975-m6lkrehi 65 14 during during IN cord-335975-m6lkrehi 65 15 the the DT cord-335975-m6lkrehi 65 16 first first JJ cord-335975-m6lkrehi 65 17 2 2 CD cord-335975-m6lkrehi 65 18 days day NNS cord-335975-m6lkrehi 65 19 . . . cord-335975-m6lkrehi 66 1 Results result NNS cord-335975-m6lkrehi 66 2 : : : cord-335975-m6lkrehi 67 1 Among among IN cord-335975-m6lkrehi 67 2 the the DT cord-335975-m6lkrehi 67 3 233 233 CD cord-335975-m6lkrehi 67 4 patients patient NNS cord-335975-m6lkrehi 67 5 included include VBN cord-335975-m6lkrehi 67 6 in in IN cord-335975-m6lkrehi 67 7 the the DT cord-335975-m6lkrehi 67 8 11 11 CD cord-335975-m6lkrehi 67 9 centers center NNS cord-335975-m6lkrehi 67 10 participating participate VBG cord-335975-m6lkrehi 67 11 to to IN cord-335975-m6lkrehi 67 12 this this DT cord-335975-m6lkrehi 67 13 ancillary ancillary JJ cord-335975-m6lkrehi 67 14 study study NN cord-335975-m6lkrehi 67 15 , , , cord-335975-m6lkrehi 67 16 a a DT cord-335975-m6lkrehi 67 17 beta beta NN cord-335975-m6lkrehi 67 18 - - HYPH cord-335975-m6lkrehi 67 19 lactam lactam NN cord-335975-m6lkrehi 67 20 trough trough NN cord-335975-m6lkrehi 67 21 concentration concentration NN cord-335975-m6lkrehi 67 22 was be VBD cord-335975-m6lkrehi 67 23 evaluated evaluate VBN cord-335975-m6lkrehi 67 24 in in IN cord-335975-m6lkrehi 67 25 112 112 CD cord-335975-m6lkrehi 67 26 subjects subject NNS cord-335975-m6lkrehi 67 27 , , , cord-335975-m6lkrehi 67 28 53 53 CD cord-335975-m6lkrehi 67 29 in in IN cord-335975-m6lkrehi 67 30 the the DT cord-335975-m6lkrehi 67 31 early early JJ cord-335975-m6lkrehi 67 32 and and CC cord-335975-m6lkrehi 67 33 59 59 CD cord-335975-m6lkrehi 67 34 in in IN cord-335975-m6lkrehi 67 35 the the DT cord-335975-m6lkrehi 67 36 delayed delay VBN cord-335975-m6lkrehi 67 37 groups group NNS cord-335975-m6lkrehi 67 38 . . . cord-335975-m6lkrehi 68 1 Ninety ninety CD cord-335975-m6lkrehi 68 2 patients patient NNS cord-335975-m6lkrehi 68 3 ( ( -LRB- cord-335975-m6lkrehi 68 4 80.4 80.4 CD cord-335975-m6lkrehi 68 5 % % NN cord-335975-m6lkrehi 68 6 ) ) -RRB- cord-335975-m6lkrehi 68 7 had have VBD cord-335975-m6lkrehi 68 8 an an DT cord-335975-m6lkrehi 68 9 adequate adequate JJ cord-335975-m6lkrehi 68 10 beta beta NN cord-335975-m6lkrehi 68 11 - - HYPH cord-335975-m6lkrehi 68 12 lactam lactam NN cord-335975-m6lkrehi 68 13 dosage dosage NN cord-335975-m6lkrehi 68 14 . . . cord-335975-m6lkrehi 69 1 RRT RRT NNP cord-335975-m6lkrehi 69 2 initiation initiation NN cord-335975-m6lkrehi 69 3 strategy strategy NN cord-335975-m6lkrehi 69 4 had have VBD cord-335975-m6lkrehi 69 5 no no DT cord-335975-m6lkrehi 69 6 impact impact NN cord-335975-m6lkrehi 69 7 on on IN cord-335975-m6lkrehi 69 8 beta beta NN cord-335975-m6lkrehi 69 9 - - HYPH cord-335975-m6lkrehi 69 10 lactam lactam NN cord-335975-m6lkrehi 69 11 concentration concentration NN cord-335975-m6lkrehi 69 12 ( ( -LRB- cord-335975-m6lkrehi 69 13 p p NN cord-335975-m6lkrehi 69 14 = = SYM cord-335975-m6lkrehi 69 15 0.78 0.78 CD cord-335975-m6lkrehi 69 16 ) ) -RRB- cord-335975-m6lkrehi 69 17 . . . cord-335975-m6lkrehi 70 1 Among among IN cord-335975-m6lkrehi 70 2 the the DT cord-335975-m6lkrehi 70 3 83 83 CD cord-335975-m6lkrehi 70 4 septic septic JJ cord-335975-m6lkrehi 70 5 shock shock NN cord-335975-m6lkrehi 70 6 patients patient NNS cord-335975-m6lkrehi 70 7 ( ( -LRB- cord-335975-m6lkrehi 70 8 74 74 CD cord-335975-m6lkrehi 70 9 % % NN cord-335975-m6lkrehi 70 10 of of IN cord-335975-m6lkrehi 70 11 the the DT cord-335975-m6lkrehi 70 12 sampled sample VBN cord-335975-m6lkrehi 70 13 patients patient NNS cord-335975-m6lkrehi 70 14 ) ) -RRB- cord-335975-m6lkrehi 70 15 , , , cord-335975-m6lkrehi 70 16 73 73 CD cord-335975-m6lkrehi 70 17 ( ( -LRB- cord-335975-m6lkrehi 70 18 88 88 CD cord-335975-m6lkrehi 70 19 % % NN cord-335975-m6lkrehi 70 20 ) ) -RRB- cord-335975-m6lkrehi 70 21 had have VBD cord-335975-m6lkrehi 70 22 a a DT cord-335975-m6lkrehi 70 23 correct correct JJ cord-335975-m6lkrehi 70 24 antibiotic antibiotic JJ cord-335975-m6lkrehi 70 25 concentration concentration NN cord-335975-m6lkrehi 70 26 . . . cord-335975-m6lkrehi 71 1 In in IN cord-335975-m6lkrehi 71 2 contrast contrast NN cord-335975-m6lkrehi 71 3 , , , cord-335975-m6lkrehi 71 4 only only RB cord-335975-m6lkrehi 71 5 10 10 CD cord-335975-m6lkrehi 71 6 of of IN cord-335975-m6lkrehi 71 7 the the DT cord-335975-m6lkrehi 71 8 16 16 CD cord-335975-m6lkrehi 71 9 patients patient NNS cord-335975-m6lkrehi 71 10 without without IN cord-335975-m6lkrehi 71 11 definite definite JJ cord-335975-m6lkrehi 71 12 sepsis sepsis NN cord-335975-m6lkrehi 71 13 ( ( -LRB- cord-335975-m6lkrehi 71 14 62.5 62.5 CD cord-335975-m6lkrehi 71 15 % % NN cord-335975-m6lkrehi 71 16 ) ) -RRB- cord-335975-m6lkrehi 71 17 had have VBD cord-335975-m6lkrehi 71 18 a a DT cord-335975-m6lkrehi 71 19 correct correct JJ cord-335975-m6lkrehi 71 20 dosage dosage NN cord-335975-m6lkrehi 71 21 . . . cord-335975-m6lkrehi 72 1 Factors factor NNS cord-335975-m6lkrehi 72 2 associated associate VBN cord-335975-m6lkrehi 72 3 with with IN cord-335975-m6lkrehi 72 4 an an DT cord-335975-m6lkrehi 72 5 adequate adequate JJ cord-335975-m6lkrehi 72 6 beta beta NN cord-335975-m6lkrehi 72 7 - - HYPH cord-335975-m6lkrehi 72 8 lactam lactam NN cord-335975-m6lkrehi 72 9 trough trough NN cord-335975-m6lkrehi 72 10 concentration concentration NN cord-335975-m6lkrehi 72 11 in in IN cord-335975-m6lkrehi 72 12 univariate univariate JJ cord-335975-m6lkrehi 72 13 analysis analysis NN cord-335975-m6lkrehi 72 14 were be VBD cord-335975-m6lkrehi 72 15 admission admission NN cord-335975-m6lkrehi 72 16 for for IN cord-335975-m6lkrehi 72 17 a a DT cord-335975-m6lkrehi 72 18 septic septic JJ cord-335975-m6lkrehi 72 19 shock shock NN cord-335975-m6lkrehi 72 20 ( ( -LRB- cord-335975-m6lkrehi 72 21 p p NN cord-335975-m6lkrehi 72 22 = = SYM cord-335975-m6lkrehi 72 23 0.002 0.002 CD cord-335975-m6lkrehi 72 24 ) ) -RRB- cord-335975-m6lkrehi 72 25 , , , cord-335975-m6lkrehi 72 26 a a DT cord-335975-m6lkrehi 72 27 higher high JJR cord-335975-m6lkrehi 72 28 plasma plasma NN cord-335975-m6lkrehi 72 29 creatinine creatinine NN cord-335975-m6lkrehi 72 30 level level NN cord-335975-m6lkrehi 72 31 ( ( -LRB- cord-335975-m6lkrehi 72 32 p p NN cord-335975-m6lkrehi 72 33 = = SYM cord-335975-m6lkrehi 72 34 0.024 0.024 CD cord-335975-m6lkrehi 72 35 ) ) -RRB- cord-335975-m6lkrehi 72 36 , , , cord-335975-m6lkrehi 72 37 a a DT cord-335975-m6lkrehi 72 38 higher high JJR cord-335975-m6lkrehi 72 39 mean mean JJ cord-335975-m6lkrehi 72 40 arterial arterial JJ cord-335975-m6lkrehi 72 41 pressure pressure NN cord-335975-m6lkrehi 72 42 ( ( -LRB- cord-335975-m6lkrehi 72 43 p p NN cord-335975-m6lkrehi 72 44 = = SYM cord-335975-m6lkrehi 72 45 0.018 0.018 CD cord-335975-m6lkrehi 72 46 ) ) -RRB- cord-335975-m6lkrehi 72 47 and and CC cord-335975-m6lkrehi 72 48 a a DT cord-335975-m6lkrehi 72 49 lower low JJR cord-335975-m6lkrehi 72 50 serum serum NN cord-335975-m6lkrehi 72 51 bicarbonate bicarbonate NN cord-335975-m6lkrehi 72 52 level level NN cord-335975-m6lkrehi 72 53 ( ( -LRB- cord-335975-m6lkrehi 72 54 p p NN cord-335975-m6lkrehi 72 55 = = SYM cord-335975-m6lkrehi 72 56 0.045 0.045 CD cord-335975-m6lkrehi 72 57 ) ) -RRB- cord-335975-m6lkrehi 72 58 at at IN cord-335975-m6lkrehi 72 59 randomization randomization NN cord-335975-m6lkrehi 72 60 . . . cord-335975-m6lkrehi 73 1 A a DT cord-335975-m6lkrehi 73 2 higher high JJR cord-335975-m6lkrehi 73 3 SOFA sofa NN cord-335975-m6lkrehi 73 4 score score NN cord-335975-m6lkrehi 73 5 was be VBD cord-335975-m6lkrehi 73 6 associated associate VBN cord-335975-m6lkrehi 73 7 with with IN cord-335975-m6lkrehi 73 8 an an DT cord-335975-m6lkrehi 73 9 adequate adequate JJ cord-335975-m6lkrehi 73 10 beta beta NN cord-335975-m6lkrehi 73 11 - - HYPH cord-335975-m6lkrehi 73 12 lactam lactam NN cord-335975-m6lkrehi 73 13 concentration concentration NN cord-335975-m6lkrehi 73 14 near near IN cord-335975-m6lkrehi 73 15 to to IN cord-335975-m6lkrehi 73 16 statistical statistical JJ cord-335975-m6lkrehi 73 17 significance significance NN cord-335975-m6lkrehi 73 18 ( ( -LRB- cord-335975-m6lkrehi 73 19 p p NN cord-335975-m6lkrehi 73 20 = = SYM cord-335975-m6lkrehi 73 21 0.053 0.053 CD cord-335975-m6lkrehi 73 22 ) ) -RRB- cord-335975-m6lkrehi 73 23 . . . cord-335975-m6lkrehi 74 1 Multivariate multivariate JJ cord-335975-m6lkrehi 74 2 analysis analysis NN cord-335975-m6lkrehi 74 3 will will MD cord-335975-m6lkrehi 74 4 be be VB cord-335975-m6lkrehi 74 5 presented present VBN cord-335975-m6lkrehi 74 6 . . . cord-335975-m6lkrehi 75 1 In in IN cord-335975-m6lkrehi 75 2 the the DT cord-335975-m6lkrehi 75 3 context context NN cord-335975-m6lkrehi 75 4 of of IN cord-335975-m6lkrehi 75 5 severe severe JJ cord-335975-m6lkrehi 75 6 AKI AKI NNP cord-335975-m6lkrehi 75 7 , , , cord-335975-m6lkrehi 75 8 beta beta NN cord-335975-m6lkrehi 75 9 - - HYPH cord-335975-m6lkrehi 75 10 lactam lactam NN cord-335975-m6lkrehi 75 11 concentration concentration NN cord-335975-m6lkrehi 75 12 reached reach VBD cord-335975-m6lkrehi 75 13 a a DT cord-335975-m6lkrehi 75 14 sufficient sufficient JJ cord-335975-m6lkrehi 75 15 level level NN cord-335975-m6lkrehi 75 16 in in IN cord-335975-m6lkrehi 75 17 88 88 CD cord-335975-m6lkrehi 75 18 % % NN cord-335975-m6lkrehi 75 19 of of IN cord-335975-m6lkrehi 75 20 septic septic JJ cord-335975-m6lkrehi 75 21 shock shock NN cord-335975-m6lkrehi 75 22 patients patient NNS cord-335975-m6lkrehi 75 23 . . . cord-335975-m6lkrehi 76 1 Interestingly interestingly RB cord-335975-m6lkrehi 76 2 , , , cord-335975-m6lkrehi 76 3 RRT RRT NNP cord-335975-m6lkrehi 76 4 initiation initiation NN cord-335975-m6lkrehi 76 5 strategy strategy NN cord-335975-m6lkrehi 76 6 was be VBD cord-335975-m6lkrehi 76 7 not not RB cord-335975-m6lkrehi 76 8 associated associate VBN cord-335975-m6lkrehi 76 9 with with IN cord-335975-m6lkrehi 76 10 beta beta NN cord-335975-m6lkrehi 76 11 - - HYPH cord-335975-m6lkrehi 76 12 lactam lactam NN cord-335975-m6lkrehi 76 13 trough trough NN cord-335975-m6lkrehi 76 14 concentration concentration NN cord-335975-m6lkrehi 76 15 . . . cord-335975-m6lkrehi 77 1 Early early RB cord-335975-m6lkrehi 77 2 RRT RRT NNP cord-335975-m6lkrehi 77 3 did do VBD cord-335975-m6lkrehi 77 4 not not RB cord-335975-m6lkrehi 77 5 affect affect VB cord-335975-m6lkrehi 77 6 trough trough IN cord-335975-m6lkrehi 77 7 concentration concentration NN cord-335975-m6lkrehi 77 8 of of IN cord-335975-m6lkrehi 77 9 betalactam betalactam NNS cord-335975-m6lkrehi 77 10 . . . cord-335975-m6lkrehi 78 1 We -PRON- PRP cord-335975-m6lkrehi 78 2 may may MD cord-335975-m6lkrehi 78 3 hypothesize hypothesize VB cord-335975-m6lkrehi 78 4 that that IN cord-335975-m6lkrehi 78 5 physicians physician NNS cord-335975-m6lkrehi 78 6 were be VBD cord-335975-m6lkrehi 78 7 highly highly RB cord-335975-m6lkrehi 78 8 vigilant vigilant JJ cord-335975-m6lkrehi 78 9 and and CC cord-335975-m6lkrehi 78 10 adapted adapt VBD cord-335975-m6lkrehi 78 11 antibiotic antibiotic JJ cord-335975-m6lkrehi 78 12 administration administration NN cord-335975-m6lkrehi 78 13 adequately adequately RB cord-335975-m6lkrehi 78 14 in in IN cord-335975-m6lkrehi 78 15 these these DT cord-335975-m6lkrehi 78 16 patients patient NNS cord-335975-m6lkrehi 78 17 . . . cord-335975-m6lkrehi 79 1 Introduction introduction NN cord-335975-m6lkrehi 79 2 : : : cord-335975-m6lkrehi 80 1 Amikacin amikacin JJ cord-335975-m6lkrehi 80 2 infusion infusion NN cord-335975-m6lkrehi 80 3 requires require VBZ cord-335975-m6lkrehi 80 4 to to TO cord-335975-m6lkrehi 80 5 target target VB cord-335975-m6lkrehi 80 6 a a DT cord-335975-m6lkrehi 80 7 peak peak NN cord-335975-m6lkrehi 80 8 serum serum NN cord-335975-m6lkrehi 80 9 concentration concentration NN cord-335975-m6lkrehi 80 10 ( ( -LRB- cord-335975-m6lkrehi 80 11 C C NNP cord-335975-m6lkrehi 80 12 max max NNP cord-335975-m6lkrehi 80 13 ) ) -RRB- cord-335975-m6lkrehi 80 14 8 8 CD cord-335975-m6lkrehi 80 15 - - SYM cord-335975-m6lkrehi 80 16 10 10 CD cord-335975-m6lkrehi 80 17 times time NNS cord-335975-m6lkrehi 80 18 the the DT cord-335975-m6lkrehi 80 19 minimal minimal JJ cord-335975-m6lkrehi 80 20 inhibitory inhibitory JJ cord-335975-m6lkrehi 80 21 concentration concentration NN cord-335975-m6lkrehi 80 22 , , , cord-335975-m6lkrehi 80 23 corresponding correspond VBG cord-335975-m6lkrehi 80 24 to to IN cord-335975-m6lkrehi 80 25 a a DT cord-335975-m6lkrehi 80 26 C c NN cord-335975-m6lkrehi 80 27 max max NN cord-335975-m6lkrehi 80 28 at at IN cord-335975-m6lkrehi 80 29 60 60 CD cord-335975-m6lkrehi 80 30 - - SYM cord-335975-m6lkrehi 80 31 80 80 CD cord-335975-m6lkrehi 80 32 mg mg NNP cord-335975-m6lkrehi 80 33 L L NNP cord-335975-m6lkrehi 80 34 −1 −1 NNP cord-335975-m6lkrehi 80 35 for for IN cord-335975-m6lkrehi 80 36 the the DT cord-335975-m6lkrehi 80 37 least least JJS cord-335975-m6lkrehi 80 38 susceptible susceptible JJ cord-335975-m6lkrehi 80 39 bacteria bacteria NNS cord-335975-m6lkrehi 80 40 . . . cord-335975-m6lkrehi 81 1 Recent recent JJ cord-335975-m6lkrehi 81 2 study study NN cord-335975-m6lkrehi 81 3 reported report VBD cord-335975-m6lkrehi 81 4 that that IN cord-335975-m6lkrehi 81 5 33 33 CD cord-335975-m6lkrehi 81 6 % % NN cord-335975-m6lkrehi 81 7 of of IN cord-335975-m6lkrehi 81 8 critically critically RB cord-335975-m6lkrehi 81 9 ill ill JJ cord-335975-m6lkrehi 81 10 patients patient NNS cord-335975-m6lkrehi 81 11 do do VBP cord-335975-m6lkrehi 81 12 not not RB cord-335975-m6lkrehi 81 13 attain attain VB cord-335975-m6lkrehi 81 14 this this DT cord-335975-m6lkrehi 81 15 target target NN cord-335975-m6lkrehi 81 16 with with IN cord-335975-m6lkrehi 81 17 a a DT cord-335975-m6lkrehi 81 18 25 25 CD cord-335975-m6lkrehi 81 19 mg mg NNP cord-335975-m6lkrehi 81 20 kg kg NNP cord-335975-m6lkrehi 81 21 dose dose NN cord-335975-m6lkrehi 81 22 ( ( -LRB- cord-335975-m6lkrehi 81 23 1 1 CD cord-335975-m6lkrehi 81 24 ) ) -RRB- cord-335975-m6lkrehi 81 25 . . . cord-335975-m6lkrehi 82 1 Membrane membrane NN cord-335975-m6lkrehi 82 2 sequestration sequestration NN cord-335975-m6lkrehi 82 3 , , , cord-335975-m6lkrehi 82 4 alteration alteration NN cord-335975-m6lkrehi 82 5 of of IN cord-335975-m6lkrehi 82 6 the the DT cord-335975-m6lkrehi 82 7 volume volume NN cord-335975-m6lkrehi 82 8 of of IN cord-335975-m6lkrehi 82 9 distribution distribution NN cord-335975-m6lkrehi 82 10 and and CC cord-335975-m6lkrehi 82 11 lack lack NN cord-335975-m6lkrehi 82 12 of of IN cord-335975-m6lkrehi 82 13 data datum NNS cord-335975-m6lkrehi 82 14 in in IN cord-335975-m6lkrehi 82 15 this this DT cord-335975-m6lkrehi 82 16 population population NN cord-335975-m6lkrehi 82 17 make make VBP cord-335975-m6lkrehi 82 18 drugs drug NNS cord-335975-m6lkrehi 82 19 pharmacokinetics pharmacokinetic NNS cord-335975-m6lkrehi 82 20 ( ( -LRB- cord-335975-m6lkrehi 82 21 PK PK NNP cord-335975-m6lkrehi 82 22 ) ) -RRB- cord-335975-m6lkrehi 82 23 on on IN cord-335975-m6lkrehi 82 24 ECMO ECMO NNP cord-335975-m6lkrehi 82 25 challenging challenge VBG cord-335975-m6lkrehi 82 26 . . . cord-335975-m6lkrehi 83 1 Our -PRON- PRP$ cord-335975-m6lkrehi 83 2 study study NN cord-335975-m6lkrehi 83 3 aimed aim VBD cord-335975-m6lkrehi 83 4 to to TO cord-335975-m6lkrehi 83 5 assess assess VB cord-335975-m6lkrehi 83 6 the the DT cord-335975-m6lkrehi 83 7 prevalence prevalence NN cord-335975-m6lkrehi 83 8 of of IN cord-335975-m6lkrehi 83 9 insufficient insufficient JJ cord-335975-m6lkrehi 83 10 Amikacin Amikacin NNP cord-335975-m6lkrehi 83 11 C C NNP cord-335975-m6lkrehi 83 12 max max NN cord-335975-m6lkrehi 83 13 in in IN cord-335975-m6lkrehi 83 14 critically critically RB cord-335975-m6lkrehi 83 15 ill ill JJ cord-335975-m6lkrehi 83 16 patients patient NNS cord-335975-m6lkrehi 83 17 on on IN cord-335975-m6lkrehi 83 18 ECMO ECMO NNP cord-335975-m6lkrehi 83 19 and and CC cord-335975-m6lkrehi 83 20 to to TO cord-335975-m6lkrehi 83 21 identify identify VB cord-335975-m6lkrehi 83 22 relative relative JJ cord-335975-m6lkrehi 83 23 risk risk NN cord-335975-m6lkrehi 83 24 factors factor NNS cord-335975-m6lkrehi 83 25 . . . cord-335975-m6lkrehi 84 1 Patients patient NNS cord-335975-m6lkrehi 84 2 and and CC cord-335975-m6lkrehi 84 3 methods method NNS cord-335975-m6lkrehi 84 4 : : : cord-335975-m6lkrehi 84 5 Prospective prospective JJ cord-335975-m6lkrehi 84 6 , , , cord-335975-m6lkrehi 84 7 observational observational JJ cord-335975-m6lkrehi 84 8 , , , cord-335975-m6lkrehi 84 9 monocentric monocentric JJ cord-335975-m6lkrehi 84 10 study study NN cord-335975-m6lkrehi 84 11 of of IN cord-335975-m6lkrehi 84 12 adult adult NN cord-335975-m6lkrehi 84 13 patients patient NNS cord-335975-m6lkrehi 84 14 on on IN cord-335975-m6lkrehi 84 15 venoarterial venoarterial NNP cord-335975-m6lkrehi 84 16 ( ( -LRB- cord-335975-m6lkrehi 84 17 VA VA NNP cord-335975-m6lkrehi 84 18 ) ) -RRB- cord-335975-m6lkrehi 84 19 or or CC cord-335975-m6lkrehi 84 20 venovenous venovenous NNP cord-335975-m6lkrehi 84 21 ( ( -LRB- cord-335975-m6lkrehi 84 22 VV VV NNP cord-335975-m6lkrehi 84 23 ) ) -RRB- cord-335975-m6lkrehi 85 1 ECMO ECMO NNP cord-335975-m6lkrehi 85 2 receiving receive VBG cord-335975-m6lkrehi 85 3 a a DT cord-335975-m6lkrehi 85 4 loading loading NN cord-335975-m6lkrehi 85 5 dose dose NN cord-335975-m6lkrehi 85 6 of of IN cord-335975-m6lkrehi 85 7 Amikacin Amikacin NNP cord-335975-m6lkrehi 85 8 for for IN cord-335975-m6lkrehi 85 9 suspected suspect VBN cord-335975-m6lkrehi 85 10 Gramnegative Gramnegative NNP cord-335975-m6lkrehi 85 11 infections infection NNS cord-335975-m6lkrehi 85 12 . . . cord-335975-m6lkrehi 86 1 Intravenous Intravenous NNP cord-335975-m6lkrehi 86 2 Amikacin Amikacin NNP cord-335975-m6lkrehi 86 3 was be VBD cord-335975-m6lkrehi 86 4 administered administer VBN cord-335975-m6lkrehi 86 5 with with IN cord-335975-m6lkrehi 86 6 a a DT cord-335975-m6lkrehi 86 7 loading loading NN cord-335975-m6lkrehi 86 8 dose dose NN cord-335975-m6lkrehi 86 9 of of IN cord-335975-m6lkrehi 86 10 25 25 CD cord-335975-m6lkrehi 86 11 mg mg NNP cord-335975-m6lkrehi 86 12 kg kg NNS cord-335975-m6lkrehi 86 13 of of IN cord-335975-m6lkrehi 86 14 total total JJ cord-335975-m6lkrehi 86 15 body body NN cord-335975-m6lkrehi 86 16 weight weight NN cord-335975-m6lkrehi 86 17 and and CC cord-335975-m6lkrehi 86 18 C C NNP cord-335975-m6lkrehi 86 19 max max NNP cord-335975-m6lkrehi 86 20 was be VBD cord-335975-m6lkrehi 86 21 measured measure VBN cord-335975-m6lkrehi 86 22 30 30 CD cord-335975-m6lkrehi 86 23 min min NN cord-335975-m6lkrehi 86 24 after after IN cord-335975-m6lkrehi 86 25 the the DT cord-335975-m6lkrehi 86 26 end end NN cord-335975-m6lkrehi 86 27 of of IN cord-335975-m6lkrehi 86 28 the the DT cord-335975-m6lkrehi 86 29 infusion infusion NN cord-335975-m6lkrehi 86 30 . . . cord-335975-m6lkrehi 87 1 Independent independent JJ cord-335975-m6lkrehi 87 2 predicators predicator NNS cord-335975-m6lkrehi 87 3 of of IN cord-335975-m6lkrehi 87 4 C C NNP cord-335975-m6lkrehi 87 5 max max NNP cord-335975-m6lkrehi 87 6 < < XX cord-335975-m6lkrehi 87 7 60 60 CD cord-335975-m6lkrehi 87 8 mg mg NNP cord-335975-m6lkrehi 87 9 L L NNP cord-335975-m6lkrehi 88 1 −1 −1 NNP cord-335975-m6lkrehi 88 2 after after IN cord-335975-m6lkrehi 88 3 the the DT cord-335975-m6lkrehi 88 4 first first JJ cord-335975-m6lkrehi 88 5 Amikacin Amikacin NNP cord-335975-m6lkrehi 88 6 infusion infusion NN cord-335975-m6lkrehi 88 7 were be VBD cord-335975-m6lkrehi 88 8 identified identify VBN cord-335975-m6lkrehi 88 9 by by IN cord-335975-m6lkrehi 88 10 mixed mixed JJ cord-335975-m6lkrehi 88 11 model model NN cord-335975-m6lkrehi 88 12 multivariate multivariate JJ cord-335975-m6lkrehi 88 13 analysis analysis NN cord-335975-m6lkrehi 88 14 . . . cord-335975-m6lkrehi 89 1 Results result NNS cord-335975-m6lkrehi 89 2 : : : cord-335975-m6lkrehi 90 1 From from IN cord-335975-m6lkrehi 90 2 January January NNP cord-335975-m6lkrehi 90 3 2015 2015 CD cord-335975-m6lkrehi 90 4 to to IN cord-335975-m6lkrehi 90 5 February February NNP cord-335975-m6lkrehi 90 6 2016 2016 CD cord-335975-m6lkrehi 90 7 , , , cord-335975-m6lkrehi 90 8 106 106 CD cord-335975-m6lkrehi 90 9 patients patient NNS cord-335975-m6lkrehi 90 10 ( ( -LRB- cord-335975-m6lkrehi 90 11 median median JJ cord-335975-m6lkrehi 90 12 SAPS sap NNS cord-335975-m6lkrehi 90 13 2 2 CD cord-335975-m6lkrehi 90 14 ( ( -LRB- cord-335975-m6lkrehi 90 15 interquartile interquartile JJ cord-335975-m6lkrehi 90 16 range range NN cord-335975-m6lkrehi 90 17 ) ) -RRB- cord-335975-m6lkrehi 90 18 68(47 68(47 CD cord-335975-m6lkrehi 90 19 - - SYM cord-335975-m6lkrehi 90 20 81 81 CD cord-335975-m6lkrehi 90 21 ) ) -RRB- cord-335975-m6lkrehi 90 22 ; ; : cord-335975-m6lkrehi 90 23 age age NN cord-335975-m6lkrehi 90 24 55(45 55(45 CD cord-335975-m6lkrehi 90 25 - - HYPH cord-335975-m6lkrehi 90 26 62 62 CD cord-335975-m6lkrehi 90 27 ) ) -RRB- cord-335975-m6lkrehi 90 28 years year NNS cord-335975-m6lkrehi 90 29 ) ) -RRB- cord-335975-m6lkrehi 90 30 under under IN cord-335975-m6lkrehi 90 31 VA VA NNP cord-335975-m6lkrehi 90 32 - - HYPH cord-335975-m6lkrehi 90 33 ECMO ECMO NNP cord-335975-m6lkrehi 90 34 ( ( -LRB- cord-335975-m6lkrehi 90 35 68 68 CD cord-335975-m6lkrehi 90 36 % % NN cord-335975-m6lkrehi 90 37 ) ) -RRB- cord-335975-m6lkrehi 90 38 or or CC cord-335975-m6lkrehi 90 39 VV VV NNP cord-335975-m6lkrehi 90 40 - - HYPH cord-335975-m6lkrehi 90 41 ECMO ECMO NNP cord-335975-m6lkrehi 90 42 ( ( -LRB- cord-335975-m6lkrehi 90 43 32 32 CD cord-335975-m6lkrehi 90 44 % % NN cord-335975-m6lkrehi 90 45 ) ) -RRB- cord-335975-m6lkrehi 90 46 were be VBD cord-335975-m6lkrehi 90 47 included include VBN cord-335975-m6lkrehi 90 48 . . . cord-335975-m6lkrehi 91 1 At at IN cord-335975-m6lkrehi 91 2 inclusion inclusion NN cord-335975-m6lkrehi 91 3 , , , cord-335975-m6lkrehi 91 4 the the DT cord-335975-m6lkrehi 91 5 SOFA sofa NN cord-335975-m6lkrehi 91 6 score score NN cord-335975-m6lkrehi 91 7 was be VBD cord-335975-m6lkrehi 91 8 15 15 CD cord-335975-m6lkrehi 91 9 ( ( -LRB- cord-335975-m6lkrehi 91 10 12 12 CD cord-335975-m6lkrehi 91 11 - - SYM cord-335975-m6lkrehi 91 12 18 18 CD cord-335975-m6lkrehi 91 13 ) ) -RRB- cord-335975-m6lkrehi 91 14 and and CC cord-335975-m6lkrehi 91 15 54 54 CD cord-335975-m6lkrehi 91 16 ( ( -LRB- cord-335975-m6lkrehi 91 17 51 51 CD cord-335975-m6lkrehi 91 18 % % NN cord-335975-m6lkrehi 91 19 ) ) -RRB- cord-335975-m6lkrehi 92 1 patients patient NNS cord-335975-m6lkrehi 92 2 were be VBD cord-335975-m6lkrehi 92 3 on on IN cord-335975-m6lkrehi 92 4 renal renal JJ cord-335975-m6lkrehi 92 5 replacement replacement NN cord-335975-m6lkrehi 92 6 therapy therapy NN cord-335975-m6lkrehi 92 7 . . . cord-335975-m6lkrehi 93 1 Overall overall JJ cord-335975-m6lkrehi 93 2 ICU ICU NNP cord-335975-m6lkrehi 93 3 mortality mortality NN cord-335975-m6lkrehi 93 4 was be VBD cord-335975-m6lkrehi 93 5 54 54 CD cord-335975-m6lkrehi 93 6 % % NN cord-335975-m6lkrehi 93 7 . . . cord-335975-m6lkrehi 94 1 C C NNP cord-335975-m6lkrehi 94 2 max max NNP cord-335975-m6lkrehi 94 3 was be VBD cord-335975-m6lkrehi 94 4 < < XX cord-335975-m6lkrehi 94 5 60 60 CD cord-335975-m6lkrehi 94 6 mg mg NNP cord-335975-m6lkrehi 94 7 L L NNP cord-335975-m6lkrehi 94 8 −1 −1 NNP cord-335975-m6lkrehi 94 9 in in IN cord-335975-m6lkrehi 94 10 41 41 CD cord-335975-m6lkrehi 94 11 ( ( -LRB- cord-335975-m6lkrehi 94 12 39 39 CD cord-335975-m6lkrehi 94 13 % % NN cord-335975-m6lkrehi 94 14 ) ) -RRB- cord-335975-m6lkrehi 94 15 of of IN cord-335975-m6lkrehi 94 16 the the DT cord-335975-m6lkrehi 94 17 patients patient NNS cord-335975-m6lkrehi 94 18 . . . cord-335975-m6lkrehi 95 1 Independent independent JJ cord-335975-m6lkrehi 95 2 risk risk NN cord-335975-m6lkrehi 95 3 factors factor NNS cord-335975-m6lkrehi 95 4 of of IN cord-335975-m6lkrehi 95 5 amikacin amikacin JJ cord-335975-m6lkrehi 95 6 under under IN cord-335975-m6lkrehi 95 7 - - HYPH cord-335975-m6lkrehi 95 8 dosing dose VBG cord-335975-m6lkrehi 95 9 were be VBD cord-335975-m6lkrehi 95 10 body body NN cord-335975-m6lkrehi 95 11 mass mass NN cord-335975-m6lkrehi 95 12 index index NN cord-335975-m6lkrehi 95 13 ( ( -LRB- cord-335975-m6lkrehi 95 14 BMI BMI NNP cord-335975-m6lkrehi 95 15 ) ) -RRB- cord-335975-m6lkrehi 95 16 < < XX cord-335975-m6lkrehi 96 1 22 22 CD cord-335975-m6lkrehi 96 2 kg kg NN cord-335975-m6lkrehi 96 3 m m NN cord-335975-m6lkrehi 96 4 −2 −2 NNP cord-335975-m6lkrehi 97 1 ( ( -LRB- cord-335975-m6lkrehi 97 2 Odds Odds NNPS cord-335975-m6lkrehi 97 3 Ratio Ratio NNP cord-335975-m6lkrehi 97 4 ( ( -LRB- cord-335975-m6lkrehi 97 5 OR OR NNP cord-335975-m6lkrehi 97 6 ) ) -RRB- cord-335975-m6lkrehi 97 7 6.38 6.38 CD cord-335975-m6lkrehi 97 8 , , , cord-335975-m6lkrehi 97 9 95 95 CD cord-335975-m6lkrehi 97 10 % % NN cord-335975-m6lkrehi 97 11 confidence confidence NN cord-335975-m6lkrehi 97 12 interval interval NN cord-335975-m6lkrehi 97 13 95%CI 95%ci CD cord-335975-m6lkrehi 97 14 1.8 1.8 CD cord-335975-m6lkrehi 97 15 - - HYPH cord-335975-m6lkrehi 97 16 22.8 22.8 CD cord-335975-m6lkrehi 97 17 , , , cord-335975-m6lkrehi 97 18 p p NN cord-335975-m6lkrehi 97 19 = = SYM cord-335975-m6lkrehi 97 20 0.043 0.043 CD cord-335975-m6lkrehi 97 21 ) ) -RRB- cord-335975-m6lkrehi 97 22 and and CC cord-335975-m6lkrehi 97 23 a a DT cord-335975-m6lkrehi 97 24 positive positive JJ cord-335975-m6lkrehi 97 25 24 24 CD cord-335975-m6lkrehi 97 26 h h NN cord-335975-m6lkrehi 97 27 fluid fluid JJ cord-335975-m6lkrehi 97 28 balance balance NN cord-335975-m6lkrehi 97 29 ( ( -LRB- cord-335975-m6lkrehi 97 30 OR or CC cord-335975-m6lkrehi 97 31 per per IN cord-335975-m6lkrehi 97 32 500 500 CD cord-335975-m6lkrehi 97 33 mL ml NN cord-335975-m6lkrehi 97 34 increment increment NN cord-335975-m6lkrehi 97 35 : : : cord-335975-m6lkrehi 97 36 1.28 1.28 CD cord-335975-m6lkrehi 97 37 , , , cord-335975-m6lkrehi 97 38 95%CI 95%ci CD cord-335975-m6lkrehi 97 39 1.05 1.05 CD cord-335975-m6lkrehi 97 40 - - SYM cord-335975-m6lkrehi 97 41 1.65 1.65 CD cord-335975-m6lkrehi 97 42 , , , cord-335975-m6lkrehi 97 43 p p NN cord-335975-m6lkrehi 97 44 = = SYM cord-335975-m6lkrehi 97 45 0.041 0.041 CD cord-335975-m6lkrehi 97 46 ) ) -RRB- cord-335975-m6lkrehi 98 1 ( ( -LRB- cord-335975-m6lkrehi 98 2 Fig Fig NNP cord-335975-m6lkrehi 98 3 . . . cord-335975-m6lkrehi 99 1 1 1 LS cord-335975-m6lkrehi 99 2 ) ) -RRB- cord-335975-m6lkrehi 99 3 . . . cord-335975-m6lkrehi 100 1 Our -PRON- PRP$ cord-335975-m6lkrehi 100 2 results result NNS cord-335975-m6lkrehi 100 3 were be VBD cord-335975-m6lkrehi 100 4 comparable comparable JJ cord-335975-m6lkrehi 100 5 to to IN cord-335975-m6lkrehi 100 6 those those DT cord-335975-m6lkrehi 100 7 observed observe VBN cord-335975-m6lkrehi 100 8 in in IN cord-335975-m6lkrehi 100 9 patients patient NNS cord-335975-m6lkrehi 100 10 treated treat VBN cord-335975-m6lkrehi 100 11 with with IN cord-335975-m6lkrehi 100 12 Amikacin Amikacin NNP cord-335975-m6lkrehi 100 13 without without IN cord-335975-m6lkrehi 100 14 ECMO ECMO NNP cord-335975-m6lkrehi 100 15 ( ( -LRB- cord-335975-m6lkrehi 100 16 1 1 CD cord-335975-m6lkrehi 100 17 ) ) -RRB- cord-335975-m6lkrehi 100 18 . . . cord-335975-m6lkrehi 101 1 Conclusion conclusion NN cord-335975-m6lkrehi 101 2 : : : cord-335975-m6lkrehi 102 1 This this DT cord-335975-m6lkrehi 102 2 large large JJ cord-335975-m6lkrehi 102 3 prospective prospective JJ cord-335975-m6lkrehi 102 4 study study NN cord-335975-m6lkrehi 102 5 suggests suggest VBZ cord-335975-m6lkrehi 102 6 that that IN cord-335975-m6lkrehi 102 7 the the DT cord-335975-m6lkrehi 102 8 prevalence prevalence NN cord-335975-m6lkrehi 102 9 and and CC cord-335975-m6lkrehi 102 10 associated associated JJ cord-335975-m6lkrehi 102 11 risk risk NN cord-335975-m6lkrehi 102 12 factors factor NNS cord-335975-m6lkrehi 102 13 of of IN cord-335975-m6lkrehi 102 14 Amikacin Amikacin NNP cord-335975-m6lkrehi 102 15 under under IN cord-335975-m6lkrehi 102 16 - - HYPH cord-335975-m6lkrehi 102 17 dosing dosing NN cord-335975-m6lkrehi 102 18 are be VBP cord-335975-m6lkrehi 102 19 similar similar JJ cord-335975-m6lkrehi 102 20 in in IN cord-335975-m6lkrehi 102 21 critically critically RB cord-335975-m6lkrehi 102 22 - - HYPH cord-335975-m6lkrehi 102 23 ill ill JJ cord-335975-m6lkrehi 102 24 patients patient NNS cord-335975-m6lkrehi 102 25 with with IN cord-335975-m6lkrehi 102 26 or or CC cord-335975-m6lkrehi 102 27 without without IN cord-335975-m6lkrehi 102 28 ECMO ECMO NNP cord-335975-m6lkrehi 102 29 . . . cord-335975-m6lkrehi 103 1 The the DT cord-335975-m6lkrehi 103 2 use use NN cord-335975-m6lkrehi 103 3 of of IN cord-335975-m6lkrehi 103 4 a a DT cord-335975-m6lkrehi 103 5 30 30 CD cord-335975-m6lkrehi 103 6 mg mg NNP cord-335975-m6lkrehi 103 7 kg kg NNS cord-335975-m6lkrehi 103 8 dose dose NN cord-335975-m6lkrehi 103 9 in in IN cord-335975-m6lkrehi 103 10 low low JJ cord-335975-m6lkrehi 103 11 BMI BMI NNP cord-335975-m6lkrehi 103 12 patients patient NNS cord-335975-m6lkrehi 103 13 and and CC cord-335975-m6lkrehi 103 14 in in IN cord-335975-m6lkrehi 103 15 those those DT cord-335975-m6lkrehi 103 16 with with IN cord-335975-m6lkrehi 103 17 a a DT cord-335975-m6lkrehi 103 18 positive positive JJ cord-335975-m6lkrehi 103 19 24-h 24-h JJ cord-335975-m6lkrehi 103 20 fluid fluid JJ cord-335975-m6lkrehi 103 21 balance balance NN cord-335975-m6lkrehi 103 22 on on IN cord-335975-m6lkrehi 103 23 ECMO ECMO NNP cord-335975-m6lkrehi 103 24 is be VBZ cord-335975-m6lkrehi 103 25 strongly strongly RB cord-335975-m6lkrehi 103 26 encouraged encouraged JJ cord-335975-m6lkrehi 103 27 to to TO cord-335975-m6lkrehi 103 28 obtain obtain VB cord-335975-m6lkrehi 103 29 adequate adequate JJ cord-335975-m6lkrehi 103 30 therapeutic therapeutic JJ cord-335975-m6lkrehi 103 31 targets target NNS cord-335975-m6lkrehi 103 32 and and CC cord-335975-m6lkrehi 103 33 prevent prevent VB cord-335975-m6lkrehi 103 34 therapeutic therapeutic JJ cord-335975-m6lkrehi 103 35 failure failure NN cord-335975-m6lkrehi 103 36 . . . cord-335975-m6lkrehi 104 1 Results result NNS cord-335975-m6lkrehi 104 2 : : : cord-335975-m6lkrehi 105 1 Fifty fifty CD cord-335975-m6lkrehi 105 2 patients patient NNS cord-335975-m6lkrehi 105 3 were be VBD cord-335975-m6lkrehi 105 4 included include VBN cord-335975-m6lkrehi 105 5 ( ( -LRB- cord-335975-m6lkrehi 105 6 29 29 CD cord-335975-m6lkrehi 105 7 with with IN cord-335975-m6lkrehi 105 8 delirium delirium NN cord-335975-m6lkrehi 105 9 , , , cord-335975-m6lkrehi 105 10 21 21 CD cord-335975-m6lkrehi 105 11 controls control NNS cord-335975-m6lkrehi 105 12 ) ) -RRB- cord-335975-m6lkrehi 105 13 , , , cord-335975-m6lkrehi 105 14 at at IN cord-335975-m6lkrehi 105 15 day day NN cord-335975-m6lkrehi 105 16 4 4 CD cord-335975-m6lkrehi 105 17 for for IN cord-335975-m6lkrehi 105 18 controls control NNS cord-335975-m6lkrehi 105 19 and and CC cord-335975-m6lkrehi 105 20 day day NN cord-335975-m6lkrehi 105 21 5 5 CD cord-335975-m6lkrehi 105 22 for for IN cord-335975-m6lkrehi 105 23 patients patient NNS cord-335975-m6lkrehi 105 24 with with IN cord-335975-m6lkrehi 105 25 confusion confusion NN cord-335975-m6lkrehi 105 26 . . . cord-335975-m6lkrehi 106 1 Delirium delirium NN cord-335975-m6lkrehi 106 2 patients patient NNS cord-335975-m6lkrehi 106 3 were be VBD cord-335975-m6lkrehi 106 4 more more RBR cord-335975-m6lkrehi 106 5 severely severely RB cord-335975-m6lkrehi 106 6 ill ill JJ cord-335975-m6lkrehi 106 7 SOFA sofa NN cord-335975-m6lkrehi 106 8 5 5 CD cord-335975-m6lkrehi 106 9 [ [ -LRB- cord-335975-m6lkrehi 106 10 3 3 CD cord-335975-m6lkrehi 106 11 ; ; : cord-335975-m6lkrehi 106 12 9 9 CD cord-335975-m6lkrehi 106 13 ] ] -RRB- cord-335975-m6lkrehi 107 1 versus versus IN cord-335975-m6lkrehi 107 2 3 3 CD cord-335975-m6lkrehi 107 3 [ [ -LRB- cord-335975-m6lkrehi 107 4 1 1 CD cord-335975-m6lkrehi 107 5 ; ; SYM cord-335975-m6lkrehi 107 6 5 5 CD cord-335975-m6lkrehi 107 7 ] ] -RRB- cord-335975-m6lkrehi 108 1 ( ( -LRB- cord-335975-m6lkrehi 108 2 p p NN cord-335975-m6lkrehi 108 3 = = SYM cord-335975-m6lkrehi 108 4 0.05 0.05 CD cord-335975-m6lkrehi 108 5 ) ) -RRB- cord-335975-m6lkrehi 108 6 ; ; : cord-335975-m6lkrehi 108 7 with with IN cord-335975-m6lkrehi 108 8 higher high JJR cord-335975-m6lkrehi 108 9 RASS RASS NNP cord-335975-m6lkrehi 108 10 1[0 1[0 CD cord-335975-m6lkrehi 108 11 ; ; : cord-335975-m6lkrehi 108 12 2 2 CD cord-335975-m6lkrehi 108 13 ] ] -RRB- cord-335975-m6lkrehi 108 14 versus versus IN cord-335975-m6lkrehi 108 15 0[0 0[0 CD cord-335975-m6lkrehi 108 16 ; ; : cord-335975-m6lkrehi 108 17 0 0 NFP cord-335975-m6lkrehi 108 18 ] ] -RRB- cord-335975-m6lkrehi 108 19 ( ( -LRB- cord-335975-m6lkrehi 108 20 p p NN cord-335975-m6lkrehi 108 21 = = SYM cord-335975-m6lkrehi 108 22 0.05 0.05 CD cord-335975-m6lkrehi 108 23 ) ) -RRB- cord-335975-m6lkrehi 108 24 . . . cord-335975-m6lkrehi 109 1 They -PRON- PRP cord-335975-m6lkrehi 109 2 presented present VBD cord-335975-m6lkrehi 109 3 with with IN cord-335975-m6lkrehi 109 4 41 41 CD cord-335975-m6lkrehi 109 5 % % NN cord-335975-m6lkrehi 109 6 BL bl NN cord-335975-m6lkrehi 109 7 overdosing overdose VBG cord-335975-m6lkrehi 109 8 versus versus IN cord-335975-m6lkrehi 109 9 19 19 CD cord-335975-m6lkrehi 109 10 % % NN cord-335975-m6lkrehi 109 11 in in IN cord-335975-m6lkrehi 109 12 controls control NNS cord-335975-m6lkrehi 109 13 ( ( -LRB- cord-335975-m6lkrehi 109 14 p p NN cord-335975-m6lkrehi 109 15 = = SYM cord-335975-m6lkrehi 109 16 0.09 0.09 CD cord-335975-m6lkrehi 109 17 ) ) -RRB- cord-335975-m6lkrehi 109 18 ; ; : cord-335975-m6lkrehi 109 19 with with IN cord-335975-m6lkrehi 109 20 41 41 CD cord-335975-m6lkrehi 109 21 % % NN cord-335975-m6lkrehi 109 22 of of IN cord-335975-m6lkrehi 109 23 BL BL NNP cord-335975-m6lkrehi 109 24 in in IN cord-335975-m6lkrehi 109 25 therapeutic therapeutic JJ cord-335975-m6lkrehi 109 26 index index NN cord-335975-m6lkrehi 109 27 : : : cord-335975-m6lkrehi 109 28 71 71 CD cord-335975-m6lkrehi 109 29 % % NN cord-335975-m6lkrehi 109 30 in in IN cord-335975-m6lkrehi 109 31 controls control NNS cord-335975-m6lkrehi 109 32 ( ( -LRB- cord-335975-m6lkrehi 109 33 p p NN cord-335975-m6lkrehi 109 34 = = SYM cord-335975-m6lkrehi 109 35 0.04 0.04 CD cord-335975-m6lkrehi 109 36 ) ) -RRB- cord-335975-m6lkrehi 109 37 . . . cord-335975-m6lkrehi 110 1 Obesity obesity NN cord-335975-m6lkrehi 110 2 and and CC cord-335975-m6lkrehi 110 3 renal renal JJ cord-335975-m6lkrehi 110 4 failure failure NN cord-335975-m6lkrehi 110 5 were be VBD cord-335975-m6lkrehi 110 6 not not RB cord-335975-m6lkrehi 110 7 associated associate VBN cord-335975-m6lkrehi 110 8 with with IN cord-335975-m6lkrehi 110 9 BL BL NNP cord-335975-m6lkrehi 110 10 overdosing overdose VBG cord-335975-m6lkrehi 110 11 but but CC cord-335975-m6lkrehi 110 12 there there EX cord-335975-m6lkrehi 110 13 was be VBD cord-335975-m6lkrehi 110 14 a a DT cord-335975-m6lkrehi 110 15 trend trend NN cord-335975-m6lkrehi 110 16 with with IN cord-335975-m6lkrehi 110 17 hypoalbuminemia hypoalbuminemia NN cord-335975-m6lkrehi 110 18 ( ( -LRB- cord-335975-m6lkrehi 110 19 p p NN cord-335975-m6lkrehi 110 20 = = SYM cord-335975-m6lkrehi 110 21 0.09 0.09 CD cord-335975-m6lkrehi 110 22 ) ) -RRB- cord-335975-m6lkrehi 110 23 . . . cord-335975-m6lkrehi 111 1 Discussion discussion NN cord-335975-m6lkrehi 111 2 : : : cord-335975-m6lkrehi 112 1 Trend trend NN cord-335975-m6lkrehi 112 2 in in IN cord-335975-m6lkrehi 112 3 association association NN cord-335975-m6lkrehi 112 4 of of IN cord-335975-m6lkrehi 112 5 BL BL NNP cord-335975-m6lkrehi 112 6 overdosing overdose VBG cord-335975-m6lkrehi 112 7 with with IN cord-335975-m6lkrehi 112 8 delirium delirium NN cord-335975-m6lkrehi 112 9 corresponds correspond VBZ cord-335975-m6lkrehi 112 10 to to IN cord-335975-m6lkrehi 112 11 previous previous JJ cord-335975-m6lkrehi 112 12 studies study NNS cord-335975-m6lkrehi 112 13 , , , cord-335975-m6lkrehi 112 14 and and CC cord-335975-m6lkrehi 112 15 would would MD cord-335975-m6lkrehi 112 16 need need VB cord-335975-m6lkrehi 112 17 a a DT cord-335975-m6lkrehi 112 18 larger large JJR cord-335975-m6lkrehi 112 19 scale scale NN cord-335975-m6lkrehi 112 20 study study NN cord-335975-m6lkrehi 112 21 to to TO cord-335975-m6lkrehi 112 22 be be VB cord-335975-m6lkrehi 112 23 confirmed confirm VBN cord-335975-m6lkrehi 112 24 . . . cord-335975-m6lkrehi 113 1 Severity severity NN cord-335975-m6lkrehi 113 2 differences difference NNS cord-335975-m6lkrehi 113 3 in in IN cord-335975-m6lkrehi 113 4 groups group NNS cord-335975-m6lkrehi 113 5 would would MD cord-335975-m6lkrehi 113 6 need need VB cord-335975-m6lkrehi 113 7 changes change NNS cord-335975-m6lkrehi 113 8 in in IN cord-335975-m6lkrehi 113 9 inclusion inclusion NN cord-335975-m6lkrehi 113 10 criteria criterion NNS cord-335975-m6lkrehi 113 11 to to TO cord-335975-m6lkrehi 113 12 obtain obtain VB cord-335975-m6lkrehi 113 13 homogeneous homogeneous JJ cord-335975-m6lkrehi 113 14 groups group NNS cord-335975-m6lkrehi 113 15 . . . cord-335975-m6lkrehi 114 1 A a DT cord-335975-m6lkrehi 114 2 possible possible JJ cord-335975-m6lkrehi 114 3 association association NN cord-335975-m6lkrehi 114 4 of of IN cord-335975-m6lkrehi 114 5 BL BL NNP cord-335975-m6lkrehi 114 6 underdosing underdose VBG cord-335975-m6lkrehi 114 7 with with IN cord-335975-m6lkrehi 114 8 poor poor JJ cord-335975-m6lkrehi 114 9 evolution evolution NN cord-335975-m6lkrehi 114 10 of of IN cord-335975-m6lkrehi 114 11 infection infection NN cord-335975-m6lkrehi 114 12 and and CC cord-335975-m6lkrehi 114 13 organ organ NN cord-335975-m6lkrehi 114 14 failures failure NNS cord-335975-m6lkrehi 114 15 would would MD cord-335975-m6lkrehi 114 16 need need VB cord-335975-m6lkrehi 114 17 more more RBR cord-335975-m6lkrehi 114 18 precise precise JJ cord-335975-m6lkrehi 114 19 evaluation evaluation NN cord-335975-m6lkrehi 114 20 . . . cord-335975-m6lkrehi 115 1 Hypoalbuminemia Hypoalbuminemia NNP cord-335975-m6lkrehi 115 2 could could MD cord-335975-m6lkrehi 115 3 have have VB cord-335975-m6lkrehi 115 4 an an DT cord-335975-m6lkrehi 115 5 impact impact NN cord-335975-m6lkrehi 115 6 on on IN cord-335975-m6lkrehi 115 7 BL BL NNP cord-335975-m6lkrehi 115 8 overdosing overdose VBG cord-335975-m6lkrehi 115 9 . . . cord-335975-m6lkrehi 116 1 Conclusion conclusion NN cord-335975-m6lkrehi 116 2 : : : cord-335975-m6lkrehi 117 1 Delirium delirium NN cord-335975-m6lkrehi 117 2 was be VBD cord-335975-m6lkrehi 117 3 not not RB cord-335975-m6lkrehi 117 4 associated associate VBN cord-335975-m6lkrehi 117 5 with with IN cord-335975-m6lkrehi 117 6 BL BL NNP cord-335975-m6lkrehi 117 7 overdosing overdose VBG cord-335975-m6lkrehi 117 8 but but CC cord-335975-m6lkrehi 117 9 with with IN cord-335975-m6lkrehi 117 10 therapeutic therapeutic JJ cord-335975-m6lkrehi 117 11 index index NN cord-335975-m6lkrehi 117 12 . . . cord-335975-m6lkrehi 118 1 A a DT cord-335975-m6lkrehi 118 2 high high JJ cord-335975-m6lkrehi 118 3 variability variability NN cord-335975-m6lkrehi 118 4 of of IN cord-335975-m6lkrehi 118 5 BL BL NNP cord-335975-m6lkrehi 118 6 concentrations concentration NNS cord-335975-m6lkrehi 118 7 warrants warrant NNS cord-335975-m6lkrehi 118 8 therapeutic therapeutic JJ cord-335975-m6lkrehi 118 9 drug drug NN cord-335975-m6lkrehi 118 10 monitoring monitoring NN cord-335975-m6lkrehi 118 11 . . . cord-335975-m6lkrehi 119 1 A a DT cord-335975-m6lkrehi 119 2 larger large JJR cord-335975-m6lkrehi 119 3 scale scale NN cord-335975-m6lkrehi 119 4 study study NN cord-335975-m6lkrehi 119 5 should should MD cord-335975-m6lkrehi 119 6 include include VB cord-335975-m6lkrehi 119 7 changes change NNS cord-335975-m6lkrehi 119 8 in in IN cord-335975-m6lkrehi 119 9 design design NN cord-335975-m6lkrehi 119 10 . . . cord-335975-m6lkrehi 120 1 Feasibility feasibility NN cord-335975-m6lkrehi 120 2 and and CC cord-335975-m6lkrehi 120 3 safety safety NN cord-335975-m6lkrehi 120 4 of of IN cord-335975-m6lkrehi 120 5 low low JJ cord-335975-m6lkrehi 120 6 - - HYPH cord-335975-m6lkrehi 120 7 flow flow NN cord-335975-m6lkrehi 120 8 extracorporeal extracorporeal NN cord-335975-m6lkrehi 120 9 CO CO NNP cord-335975-m6lkrehi 120 10 2 2 CD cord-335975-m6lkrehi 120 11 removal removal NN cord-335975-m6lkrehi 120 12 with with IN cord-335975-m6lkrehi 120 13 a a DT cord-335975-m6lkrehi 120 14 renal renal JJ cord-335975-m6lkrehi 120 15 replacement replacement NN cord-335975-m6lkrehi 120 16 platform platform NN cord-335975-m6lkrehi 120 17 to to TO cord-335975-m6lkrehi 120 18 enhance enhance VB cord-335975-m6lkrehi 120 19 lung lung NN cord-335975-m6lkrehi 120 20 protective protective JJ cord-335975-m6lkrehi 120 21 ventilation ventilation NN cord-335975-m6lkrehi 120 22 in in IN cord-335975-m6lkrehi 120 23 patients patient NNS cord-335975-m6lkrehi 120 24 with with IN cord-335975-m6lkrehi 120 25 mild mild JJ cord-335975-m6lkrehi 120 26 to to TO cord-335975-m6lkrehi 120 27 moderate moderate JJ cord-335975-m6lkrehi 120 28 ARDS ARDS NNP cord-335975-m6lkrehi 120 29 Schmidt Schmidt NNP cord-335975-m6lkrehi 120 30 Matthieu Matthieu NNP cord-335975-m6lkrehi 120 31 1 1 CD cord-335975-m6lkrehi 120 32 , , , cord-335975-m6lkrehi 120 33 Jaber Jaber NNP cord-335975-m6lkrehi 120 34 Samir Samir NNP cord-335975-m6lkrehi 120 35 1 1 CD cord-335975-m6lkrehi 121 1 , , , cord-335975-m6lkrehi 121 2 Constantin Constantin NNP cord-335975-m6lkrehi 121 3 Introduction introduction NN cord-335975-m6lkrehi 121 4 : : : cord-335975-m6lkrehi 121 5 Extracorporeal extracorporeal JJ cord-335975-m6lkrehi 121 6 carbon carbon NN cord-335975-m6lkrehi 121 7 dioxide dioxide NN cord-335975-m6lkrehi 121 8 removal removal NN cord-335975-m6lkrehi 121 9 ( ( -LRB- cord-335975-m6lkrehi 121 10 ECCO2R ecco2r NN cord-335975-m6lkrehi 121 11 ) ) -RRB- cord-335975-m6lkrehi 121 12 might may MD cord-335975-m6lkrehi 121 13 allow allow VB cord-335975-m6lkrehi 121 14 ultraprotective ultraprotective JJ cord-335975-m6lkrehi 121 15 mechanical mechanical JJ cord-335975-m6lkrehi 121 16 ventilation ventilation NN cord-335975-m6lkrehi 121 17 with with IN cord-335975-m6lkrehi 121 18 lower low JJR cord-335975-m6lkrehi 121 19 tidal tidal JJ cord-335975-m6lkrehi 121 20 volume volume NN cord-335975-m6lkrehi 121 21 ( ( -LRB- cord-335975-m6lkrehi 121 22 VT VT NNP cord-335975-m6lkrehi 121 23 ) ) -RRB- cord-335975-m6lkrehi 121 24 ( ( -LRB- cord-335975-m6lkrehi 121 25 < < XX cord-335975-m6lkrehi 121 26 6 6 CD cord-335975-m6lkrehi 121 27 mL ml NN cord-335975-m6lkrehi 121 28 kg kg NN cord-335975-m6lkrehi 121 29 ideal ideal JJ cord-335975-m6lkrehi 121 30 body body NN cord-335975-m6lkrehi 121 31 weight weight NN cord-335975-m6lkrehi 121 32 ) ) -RRB- cord-335975-m6lkrehi 121 33 , , , cord-335975-m6lkrehi 121 34 plateau plateau NN cord-335975-m6lkrehi 121 35 pressure pressure NN cord-335975-m6lkrehi 121 36 ( ( -LRB- cord-335975-m6lkrehi 121 37 Pplat Pplat NNP cord-335975-m6lkrehi 121 38 ) ) -RRB- cord-335975-m6lkrehi 121 39 ( ( -LRB- cord-335975-m6lkrehi 121 40 < < NNP cord-335975-m6lkrehi 121 41 30 30 CD cord-335975-m6lkrehi 121 42 cm cm NN cord-335975-m6lkrehi 121 43 H h NN cord-335975-m6lkrehi 121 44 2 2 CD cord-335975-m6lkrehi 121 45 O o NN cord-335975-m6lkrehi 121 46 ) ) -RRB- cord-335975-m6lkrehi 121 47 , , , cord-335975-m6lkrehi 121 48 driving drive VBG cord-335975-m6lkrehi 121 49 pressure pressure NN cord-335975-m6lkrehi 121 50 , , , cord-335975-m6lkrehi 121 51 and and CC cord-335975-m6lkrehi 121 52 respiratory respiratory JJ cord-335975-m6lkrehi 121 53 rate rate NN cord-335975-m6lkrehi 121 54 ( ( -LRB- cord-335975-m6lkrehi 121 55 RR rr NN cord-335975-m6lkrehi 121 56 ) ) -RRB- cord-335975-m6lkrehi 121 57 to to TO cord-335975-m6lkrehi 121 58 reduce reduce VB cord-335975-m6lkrehi 121 59 ventilator ventilator NN cord-335975-m6lkrehi 121 60 induced induce VBN cord-335975-m6lkrehi 121 61 lung lung NN cord-335975-m6lkrehi 121 62 injury injury NN cord-335975-m6lkrehi 121 63 ( ( -LRB- cord-335975-m6lkrehi 121 64 VILI VILI NNP cord-335975-m6lkrehi 121 65 ) ) -RRB- cord-335975-m6lkrehi 121 66 . . . cord-335975-m6lkrehi 122 1 The the DT cord-335975-m6lkrehi 122 2 aim aim NN cord-335975-m6lkrehi 122 3 of of IN cord-335975-m6lkrehi 122 4 this this DT cord-335975-m6lkrehi 122 5 study study NN cord-335975-m6lkrehi 122 6 was be VBD cord-335975-m6lkrehi 122 7 to to TO cord-335975-m6lkrehi 122 8 assess assess VB cord-335975-m6lkrehi 122 9 the the DT cord-335975-m6lkrehi 122 10 feasibility feasibility NN cord-335975-m6lkrehi 122 11 and and CC cord-335975-m6lkrehi 122 12 safety safety NN cord-335975-m6lkrehi 122 13 of of IN cord-335975-m6lkrehi 122 14 ECCO2R ECCO2R NNP cord-335975-m6lkrehi 122 15 with with IN cord-335975-m6lkrehi 122 16 a a DT cord-335975-m6lkrehi 122 17 renal renal JJ cord-335975-m6lkrehi 122 18 replacement replacement NN cord-335975-m6lkrehi 122 19 platform platform NN cord-335975-m6lkrehi 122 20 ( ( -LRB- cord-335975-m6lkrehi 122 21 RRT rrt NN cord-335975-m6lkrehi 122 22 ) ) -RRB- cord-335975-m6lkrehi 122 23 to to TO cord-335975-m6lkrehi 122 24 permit permit VB cord-335975-m6lkrehi 122 25 ultra ultra JJ cord-335975-m6lkrehi 122 26 - - JJ cord-335975-m6lkrehi 122 27 protective protective JJ cord-335975-m6lkrehi 122 28 ventilation ventilation NN cord-335975-m6lkrehi 122 29 in in IN cord-335975-m6lkrehi 122 30 patients patient NNS cord-335975-m6lkrehi 122 31 with with IN cord-335975-m6lkrehi 122 32 mild mild JJ cord-335975-m6lkrehi 122 33 to to TO cord-335975-m6lkrehi 122 34 moderate moderate VB cord-335975-m6lkrehi 122 35 acute acute JJ cord-335975-m6lkrehi 122 36 respiratory respiratory JJ cord-335975-m6lkrehi 122 37 distress distress NN cord-335975-m6lkrehi 122 38 syndrome syndrome NN cord-335975-m6lkrehi 122 39 ( ( -LRB- cord-335975-m6lkrehi 122 40 ARDS ARDS NNP cord-335975-m6lkrehi 122 41 ) ) -RRB- cord-335975-m6lkrehi 122 42 . . . cord-335975-m6lkrehi 123 1 Patients patient NNS cord-335975-m6lkrehi 123 2 and and CC cord-335975-m6lkrehi 123 3 methods method NNS cord-335975-m6lkrehi 123 4 : : : cord-335975-m6lkrehi 123 5 Twenty twenty CD cord-335975-m6lkrehi 123 6 patients patient NNS cord-335975-m6lkrehi 123 7 with with IN cord-335975-m6lkrehi 123 8 mild mild JJ cord-335975-m6lkrehi 123 9 ( ( -LRB- cord-335975-m6lkrehi 123 10 n n NN cord-335975-m6lkrehi 123 11 = = SYM cord-335975-m6lkrehi 123 12 8) 8) NN cord-335975-m6lkrehi 123 13 or or CC cord-335975-m6lkrehi 123 14 moderate moderate JJ cord-335975-m6lkrehi 123 15 ARDS ARDS NNP cord-335975-m6lkrehi 123 16 were be VBD cord-335975-m6lkrehi 123 17 included include VBN cord-335975-m6lkrehi 123 18 . . . cord-335975-m6lkrehi 124 1 VT VT NNP cord-335975-m6lkrehi 124 2 was be VBD cord-335975-m6lkrehi 124 3 gradually gradually RB cord-335975-m6lkrehi 124 4 reduced reduce VBN cord-335975-m6lkrehi 124 5 from from IN cord-335975-m6lkrehi 124 6 6 6 CD cord-335975-m6lkrehi 124 7 to to IN cord-335975-m6lkrehi 124 8 5 5 CD cord-335975-m6lkrehi 124 9 , , , cord-335975-m6lkrehi 124 10 4.5 4.5 CD cord-335975-m6lkrehi 124 11 and and CC cord-335975-m6lkrehi 124 12 4 4 CD cord-335975-m6lkrehi 124 13 mL ml NN cord-335975-m6lkrehi 124 14 kg kg NNP cord-335975-m6lkrehi 124 15 −1 −1 NNP cord-335975-m6lkrehi 124 16 and and CC cord-335975-m6lkrehi 124 17 PEEP PEEP NNP cord-335975-m6lkrehi 124 18 adjusted adjust VBD cord-335975-m6lkrehi 124 19 to to TO cord-335975-m6lkrehi 124 20 reach reach VB cord-335975-m6lkrehi 124 21 23 23 CD cord-335975-m6lkrehi 125 1 > > XX cord-335975-m6lkrehi 126 1 Pplat Pplat NNP cord-335975-m6lkrehi 126 2 > > XX cord-335975-m6lkrehi 126 3 25 25 CD cord-335975-m6lkrehi 126 4 cm cm NN cord-335975-m6lkrehi 126 5 H h NN cord-335975-m6lkrehi 126 6 2 2 CD cord-335975-m6lkrehi 126 7 O. o. NN cord-335975-m6lkrehi 126 8 Standalone standalone JJ cord-335975-m6lkrehi 126 9 ECCO2R ecco2r NN cord-335975-m6lkrehi 127 1 ( ( -LRB- cord-335975-m6lkrehi 127 2 no no DT cord-335975-m6lkrehi 127 3 hemofilter hemofilter NN cord-335975-m6lkrehi 127 4 associated associate VBN cord-335975-m6lkrehi 127 5 on on IN cord-335975-m6lkrehi 127 6 the the DT cord-335975-m6lkrehi 127 7 RRT RRT NNP cord-335975-m6lkrehi 127 8 platform platform NN cord-335975-m6lkrehi 127 9 ) ) -RRB- cord-335975-m6lkrehi 127 10 was be VBD cord-335975-m6lkrehi 127 11 initiated initiate VBN cord-335975-m6lkrehi 127 12 when when WRB cord-335975-m6lkrehi 127 13 arterial arterial JJ cord-335975-m6lkrehi 127 14 PaCO2 PaCO2 NNP cord-335975-m6lkrehi 127 15 increased increase VBD cord-335975-m6lkrehi 127 16 by by IN cord-335975-m6lkrehi 127 17 more more JJR cord-335975-m6lkrehi 127 18 than than IN cord-335975-m6lkrehi 127 19 20 20 CD cord-335975-m6lkrehi 127 20 % % NN cord-335975-m6lkrehi 127 21 . . . cord-335975-m6lkrehi 128 1 Ventilation ventilation NN cord-335975-m6lkrehi 128 2 parameters parameter NNS cord-335975-m6lkrehi 128 3 ( ( -LRB- cord-335975-m6lkrehi 128 4 VT VT NNP cord-335975-m6lkrehi 128 5 , , , cord-335975-m6lkrehi 128 6 RR RR NNP cord-335975-m6lkrehi 128 7 , , , cord-335975-m6lkrehi 128 8 PEEP PEEP NNP cord-335975-m6lkrehi 128 9 ) ) -RRB- cord-335975-m6lkrehi 128 10 , , , cord-335975-m6lkrehi 128 11 respiratory respiratory JJ cord-335975-m6lkrehi 128 12 compliance compliance NN cord-335975-m6lkrehi 128 13 , , , cord-335975-m6lkrehi 128 14 driving drive VBG cord-335975-m6lkrehi 128 15 pressure pressure NN cord-335975-m6lkrehi 128 16 , , , cord-335975-m6lkrehi 128 17 arterial arterial JJ cord-335975-m6lkrehi 128 18 blood blood NN cord-335975-m6lkrehi 128 19 gases gas NNS cord-335975-m6lkrehi 128 20 , , , cord-335975-m6lkrehi 128 21 and and CC cord-335975-m6lkrehi 128 22 ECCO2R ecco2r NN cord-335975-m6lkrehi 128 23 system system NN cord-335975-m6lkrehi 128 24 operational operational JJ cord-335975-m6lkrehi 128 25 characteristics characteristic NNS cord-335975-m6lkrehi 128 26 ( ( -LRB- cord-335975-m6lkrehi 128 27 blood blood NN cord-335975-m6lkrehi 128 28 flow flow NN cord-335975-m6lkrehi 128 29 , , , cord-335975-m6lkrehi 128 30 sweep sweep VB cord-335975-m6lkrehi 128 31 gas gas NN cord-335975-m6lkrehi 128 32 flow flow NN cord-335975-m6lkrehi 128 33 , , , cord-335975-m6lkrehi 128 34 and and CC cord-335975-m6lkrehi 128 35 CO CO NNP cord-335975-m6lkrehi 128 36 2 2 CD cord-335975-m6lkrehi 128 37 removal removal NN cord-335975-m6lkrehi 128 38 rate rate NN cord-335975-m6lkrehi 128 39 ) ) -RRB- cord-335975-m6lkrehi 128 40 were be VBD cord-335975-m6lkrehi 128 41 collected collect VBN cord-335975-m6lkrehi 128 42 during during IN cord-335975-m6lkrehi 128 43 a a DT cord-335975-m6lkrehi 128 44 minimum minimum NN cord-335975-m6lkrehi 128 45 of of IN cord-335975-m6lkrehi 128 46 24 24 CD cord-335975-m6lkrehi 128 47 h h NN cord-335975-m6lkrehi 128 48 of of IN cord-335975-m6lkrehi 128 49 ultra ultra JJ cord-335975-m6lkrehi 128 50 - - JJ cord-335975-m6lkrehi 128 51 protective protective JJ cord-335975-m6lkrehi 128 52 ventilation ventilation NN cord-335975-m6lkrehi 128 53 . . . cord-335975-m6lkrehi 129 1 Complications complication NNS cord-335975-m6lkrehi 129 2 , , , cord-335975-m6lkrehi 129 3 mortality mortality NN cord-335975-m6lkrehi 129 4 at at IN cord-335975-m6lkrehi 129 5 day day NN cord-335975-m6lkrehi 129 6 28 28 CD cord-335975-m6lkrehi 129 7 , , , cord-335975-m6lkrehi 129 8 need need VBP cord-335975-m6lkrehi 129 9 for for IN cord-335975-m6lkrehi 129 10 adjuvant adjuvant JJ cord-335975-m6lkrehi 129 11 therapies therapy NNS cord-335975-m6lkrehi 129 12 and and CC cord-335975-m6lkrehi 129 13 data datum NNS cord-335975-m6lkrehi 129 14 on on IN cord-335975-m6lkrehi 129 15 weaning wean VBG cord-335975-m6lkrehi 129 16 from from IN cord-335975-m6lkrehi 129 17 both both DT cord-335975-m6lkrehi 129 18 mechanical mechanical JJ cord-335975-m6lkrehi 129 19 ventilation ventilation NN cord-335975-m6lkrehi 129 20 and and CC cord-335975-m6lkrehi 129 21 ECCO2R ECCO2R NNP cord-335975-m6lkrehi 129 22 were be VBD cord-335975-m6lkrehi 129 23 also also RB cord-335975-m6lkrehi 129 24 collected collect VBN cord-335975-m6lkrehi 129 25 . . . cord-335975-m6lkrehi 130 1 Results result NNS cord-335975-m6lkrehi 130 2 : : : cord-335975-m6lkrehi 131 1 While while IN cord-335975-m6lkrehi 131 2 VT VT NNP cord-335975-m6lkrehi 131 3 was be VBD cord-335975-m6lkrehi 131 4 reduced reduce VBN cord-335975-m6lkrehi 131 5 from from IN cord-335975-m6lkrehi 131 6 6 6 CD cord-335975-m6lkrehi 131 7 to to IN cord-335975-m6lkrehi 131 8 4 4 CD cord-335975-m6lkrehi 131 9 mL ml NN cord-335975-m6lkrehi 131 10 kg kg NNP cord-335975-m6lkrehi 131 11 −1 −1 NNP cord-335975-m6lkrehi 131 12 and and CC cord-335975-m6lkrehi 131 13 Pplat Pplat NNP cord-335975-m6lkrehi 131 14 kept keep VBD cord-335975-m6lkrehi 131 15 below below IN cord-335975-m6lkrehi 131 16 25 25 CD cord-335975-m6lkrehi 131 17 cm cm NNS cord-335975-m6lkrehi 131 18 H h NN cord-335975-m6lkrehi 131 19 2 2 CD cord-335975-m6lkrehi 131 20 O o NN cord-335975-m6lkrehi 131 21 , , , cord-335975-m6lkrehi 131 22 PEEP PEEP NNP cord-335975-m6lkrehi 131 23 was be VBD cord-335975-m6lkrehi 131 24 significantly significantly RB cord-335975-m6lkrehi 131 25 increased increase VBN cord-335975-m6lkrehi 131 26 from from IN cord-335975-m6lkrehi 131 27 13.4 13.4 CD cord-335975-m6lkrehi 131 28 ± ± NNP cord-335975-m6lkrehi 131 29 3.6 3.6 CD cord-335975-m6lkrehi 131 30 at at IN cord-335975-m6lkrehi 131 31 baseline baseline NN cord-335975-m6lkrehi 131 32 to to IN cord-335975-m6lkrehi 131 33 15.0 15.0 CD cord-335975-m6lkrehi 131 34 ± ± NNP cord-335975-m6lkrehi 131 35 3.4 3.4 CD cord-335975-m6lkrehi 131 36 cm cm NN cord-335975-m6lkrehi 131 37 H h NN cord-335975-m6lkrehi 131 38 2 2 CD cord-335975-m6lkrehi 131 39 O o NN cord-335975-m6lkrehi 131 40 at at IN cord-335975-m6lkrehi 131 41 VT VT NNP cord-335975-m6lkrehi 131 42 = = NFP cord-335975-m6lkrehi 132 1 4 4 LS cord-335975-m6lkrehi 132 2 mL ml NN cord-335975-m6lkrehi 132 3 kg kg NNP cord-335975-m6lkrehi 132 4 −1 −1 NNP cord-335975-m6lkrehi 132 5 . . . cord-335975-m6lkrehi 133 1 As as IN cord-335975-m6lkrehi 133 2 a a DT cord-335975-m6lkrehi 133 3 result result NN cord-335975-m6lkrehi 133 4 , , , cord-335975-m6lkrehi 133 5 the the DT cord-335975-m6lkrehi 133 6 driving drive VBG cord-335975-m6lkrehi 133 7 pressure pressure NN cord-335975-m6lkrehi 133 8 was be VBD cord-335975-m6lkrehi 133 9 significantly significantly RB cord-335975-m6lkrehi 133 10 reduced reduce VBN cord-335975-m6lkrehi 133 11 to to IN cord-335975-m6lkrehi 133 12 7.9 7.9 CD cord-335975-m6lkrehi 133 13 ± ± NNP cord-335975-m6lkrehi 133 14 3.2 3.2 CD cord-335975-m6lkrehi 133 15 cm cm NN cord-335975-m6lkrehi 133 16 H h NN cord-335975-m6lkrehi 133 17 2 2 CD cord-335975-m6lkrehi 133 18 O o NN cord-335975-m6lkrehi 133 19 at at IN cord-335975-m6lkrehi 133 20 VT VT NNP cord-335975-m6lkrehi 133 21 = = NFP cord-335975-m6lkrehi 134 1 4 4 LS cord-335975-m6lkrehi 134 2 mL ml NN cord-335975-m6lkrehi 134 3 kg kg NN cord-335975-m6lkrehi 134 4 −1 −1 NNP cord-335975-m6lkrehi 134 5 ( ( -LRB- cord-335975-m6lkrehi 134 6 p p NN cord-335975-m6lkrehi 134 7 < < XX cord-335975-m6lkrehi 134 8 0.05 0.05 CD cord-335975-m6lkrehi 134 9 ) ) -RRB- cord-335975-m6lkrehi 135 1 ( ( -LRB- cord-335975-m6lkrehi 135 2 Fig Fig NNP cord-335975-m6lkrehi 135 3 . . NNP cord-335975-m6lkrehi 135 4 1 1 CD cord-335975-m6lkrehi 135 5 ) ) -RRB- cord-335975-m6lkrehi 135 6 . . . cord-335975-m6lkrehi 136 1 No no DT cord-335975-m6lkrehi 136 2 significant significant JJ cord-335975-m6lkrehi 136 3 differences difference NNS cord-335975-m6lkrehi 136 4 in in IN cord-335975-m6lkrehi 136 5 RR RR NNP cord-335975-m6lkrehi 136 6 , , , cord-335975-m6lkrehi 136 7 PaO2 PaO2 NNPS cord-335975-m6lkrehi 136 8 FiO2 FiO2 NNS cord-335975-m6lkrehi 136 9 ratio ratio NN cord-335975-m6lkrehi 136 10 , , , cord-335975-m6lkrehi 136 11 respiratory respiratory JJ cord-335975-m6lkrehi 136 12 system system NN cord-335975-m6lkrehi 136 13 compliance compliance NN cord-335975-m6lkrehi 136 14 were be VBD cord-335975-m6lkrehi 136 15 observed observe VBN cord-335975-m6lkrehi 136 16 after after IN cord-335975-m6lkrehi 136 17 Vt Vt NNP cord-335975-m6lkrehi 136 18 reduction reduction NN cord-335975-m6lkrehi 136 19 . . . cord-335975-m6lkrehi 137 1 Mean mean JJ cord-335975-m6lkrehi 137 2 extracorporeal extracorporeal JJ cord-335975-m6lkrehi 137 3 blood blood NN cord-335975-m6lkrehi 137 4 , , , cord-335975-m6lkrehi 137 5 sweep sweep VB cord-335975-m6lkrehi 137 6 gas gas NN cord-335975-m6lkrehi 137 7 flow flow NN cord-335975-m6lkrehi 137 8 and and CC cord-335975-m6lkrehi 137 9 CO CO NNP cord-335975-m6lkrehi 137 10 2 2 CD cord-335975-m6lkrehi 137 11 removal removal NN cord-335975-m6lkrehi 137 12 were be VBD cord-335975-m6lkrehi 137 13 421 421 CD cord-335975-m6lkrehi 137 14 ± ± CD cord-335975-m6lkrehi 137 15 40 40 CD cord-335975-m6lkrehi 137 16 mL ml NN cord-335975-m6lkrehi 137 17 min min NN cord-335975-m6lkrehi 137 18 −1 −1 NNP cord-335975-m6lkrehi 137 19 , , , cord-335975-m6lkrehi 137 20 10 10 CD cord-335975-m6lkrehi 137 21 ± ± NNP cord-335975-m6lkrehi 137 22 0.3 0.3 CD cord-335975-m6lkrehi 137 23 L l NN cord-335975-m6lkrehi 137 24 min min NNP cord-335975-m6lkrehi 137 25 −1 −1 NNP cord-335975-m6lkrehi 137 26 and and CC cord-335975-m6lkrehi 137 27 51 51 CD cord-335975-m6lkrehi 137 28 mL ml NN cord-335975-m6lkrehi 137 29 min min NN cord-335975-m6lkrehi 137 30 −1 −1 NNP cord-335975-m6lkrehi 137 31 , , , cord-335975-m6lkrehi 137 32 respectively respectively RB cord-335975-m6lkrehi 137 33 . . . cord-335975-m6lkrehi 138 1 Mean mean JJ cord-335975-m6lkrehi 138 2 treatment treatment NN cord-335975-m6lkrehi 138 3 duration duration NN cord-335975-m6lkrehi 138 4 was be VBD cord-335975-m6lkrehi 138 5 31 31 CD cord-335975-m6lkrehi 138 6 ± ± NNP cord-335975-m6lkrehi 138 7 22 22 CD cord-335975-m6lkrehi 138 8 h. h. NN cord-335975-m6lkrehi 138 9 Main main JJ cord-335975-m6lkrehi 138 10 side side NN cord-335975-m6lkrehi 138 11 effects effect NNS cord-335975-m6lkrehi 138 12 related relate VBN cord-335975-m6lkrehi 138 13 to to IN cord-335975-m6lkrehi 138 14 ECCO2R ECCO2R NNP cord-335975-m6lkrehi 138 15 were be VBD cord-335975-m6lkrehi 138 16 membrane membrane NN cord-335975-m6lkrehi 138 17 clotting clotting NN cord-335975-m6lkrehi 138 18 which which WDT cord-335975-m6lkrehi 138 19 occurred occur VBD cord-335975-m6lkrehi 138 20 in in IN cord-335975-m6lkrehi 138 21 7 7 CD cord-335975-m6lkrehi 138 22 patients patient NNS cord-335975-m6lkrehi 138 23 after after IN cord-335975-m6lkrehi 138 24 19 19 CD cord-335975-m6lkrehi 138 25 ± ± NNP cord-335975-m6lkrehi 138 26 9 9 CD cord-335975-m6lkrehi 138 27 h. h. NN cord-335975-m6lkrehi 138 28 Conclusion conclusion NN cord-335975-m6lkrehi 138 29 : : : cord-335975-m6lkrehi 139 1 A a DT cord-335975-m6lkrehi 139 2 low low JJ cord-335975-m6lkrehi 139 3 - - HYPH cord-335975-m6lkrehi 139 4 flow flow NN cord-335975-m6lkrehi 139 5 ECCO2R ecco2r NN cord-335975-m6lkrehi 139 6 device device NN cord-335975-m6lkrehi 139 7 driven drive VBN cord-335975-m6lkrehi 139 8 by by IN cord-335975-m6lkrehi 139 9 a a DT cord-335975-m6lkrehi 139 10 RRT RRT NNP cord-335975-m6lkrehi 139 11 platform platform NN cord-335975-m6lkrehi 139 12 efficiently efficiently RB cord-335975-m6lkrehi 139 13 removed remove VBD cord-335975-m6lkrehi 139 14 CO2 CO2 NNP cord-335975-m6lkrehi 139 15 while while IN cord-335975-m6lkrehi 139 16 allowing allow VBG cord-335975-m6lkrehi 139 17 ultra ultra JJ cord-335975-m6lkrehi 139 18 - - JJ cord-335975-m6lkrehi 139 19 protective protective JJ cord-335975-m6lkrehi 139 20 mechanical mechanical JJ cord-335975-m6lkrehi 139 21 ventilation ventilation NN cord-335975-m6lkrehi 139 22 settings setting NNS cord-335975-m6lkrehi 139 23 in in IN cord-335975-m6lkrehi 139 24 patients patient NNS cord-335975-m6lkrehi 139 25 with with IN cord-335975-m6lkrehi 139 26 mild mild JJ cord-335975-m6lkrehi 139 27 to to IN cord-335975-m6lkrehi 139 28 moderate moderate JJ cord-335975-m6lkrehi 139 29 ARDS ARDS NNP cord-335975-m6lkrehi 139 30 ( ( -LRB- cord-335975-m6lkrehi 139 31 ClinicalTrials ClinicalTrials NNP cord-335975-m6lkrehi 139 32 . . . cord-335975-m6lkrehi 140 1 gov gov NNP cord-335975-m6lkrehi 140 2 identifier identifier NNP cord-335975-m6lkrehi 140 3 : : : cord-335975-m6lkrehi 140 4 NCT02606240 NCT02606240 NNP cord-335975-m6lkrehi 140 5 ) ) -RRB- cord-335975-m6lkrehi 140 6 . . . cord-335975-m6lkrehi 141 1 Morimont Morimont NNP cord-335975-m6lkrehi 141 2 Philippe Philippe NNP cord-335975-m6lkrehi 141 3 1 1 CD cord-335975-m6lkrehi 141 4 , , , cord-335975-m6lkrehi 141 5 Habran Habran NNP cord-335975-m6lkrehi 141 6 Simon Simon NNP cord-335975-m6lkrehi 141 7 1 1 CD cord-335975-m6lkrehi 141 8 , , , cord-335975-m6lkrehi 141 9 Desaive Desaive NNP cord-335975-m6lkrehi 141 10 Thomas Thomas NNP cord-335975-m6lkrehi 141 11 1 1 CD cord-335975-m6lkrehi 141 12 , , , cord-335975-m6lkrehi 141 13 Janssen Janssen NNP cord-335975-m6lkrehi 141 14 Nathalie Nathalie NNP cord-335975-m6lkrehi 141 15 1 1 CD cord-335975-m6lkrehi 141 16 , , , cord-335975-m6lkrehi 141 17 Amand Amand NNP cord-335975-m6lkrehi 141 18 Theophile Theophile NNP cord-335975-m6lkrehi 141 19 1 1 CD cord-335975-m6lkrehi 141 20 , , , cord-335975-m6lkrehi 141 21 Blaffart Blaffart NNP cord-335975-m6lkrehi 141 22 Francine Francine NNP cord-335975-m6lkrehi 141 23 1 1 CD cord-335975-m6lkrehi 141 24 , , , cord-335975-m6lkrehi 141 25 Dauby Dauby NNP cord-335975-m6lkrehi 141 26 Pierre Pierre NNP cord-335975-m6lkrehi 141 27 1 1 CD cord-335975-m6lkrehi 141 28 , , , cord-335975-m6lkrehi 141 29 Kolh Kolh NNP cord-335975-m6lkrehi 141 30 Philippe Philippe NNP cord-335975-m6lkrehi 141 31 1 1 CD cord-335975-m6lkrehi 141 32 , , , cord-335975-m6lkrehi 141 33 Defraigne Defraigne NNP cord-335975-m6lkrehi 141 34 Jean Jean NNP cord-335975-m6lkrehi 141 35 - - HYPH cord-335975-m6lkrehi 141 36 Olivier Olivier NNP cord-335975-m6lkrehi 141 37 1 1 CD cord-335975-m6lkrehi 141 38 , , , cord-335975-m6lkrehi 141 39 Lambermont Lambermont NNP cord-335975-m6lkrehi 141 40 Bernard Bernard NNP cord-335975-m6lkrehi 141 41 1 1 CD cord-335975-m6lkrehi 141 42 Introduction introduction NN cord-335975-m6lkrehi 141 43 : : : cord-335975-m6lkrehi 141 44 Protective protective JJ cord-335975-m6lkrehi 141 45 lung lung NN cord-335975-m6lkrehi 141 46 ventilation ventilation NN cord-335975-m6lkrehi 141 47 ( ( -LRB- cord-335975-m6lkrehi 141 48 PLV PLV NNP cord-335975-m6lkrehi 141 49 ) ) -RRB- cord-335975-m6lkrehi 141 50 is be VBZ cord-335975-m6lkrehi 141 51 recommended recommend VBN cord-335975-m6lkrehi 141 52 in in IN cord-335975-m6lkrehi 141 53 patients patient NNS cord-335975-m6lkrehi 141 54 with with IN cord-335975-m6lkrehi 141 55 acute acute JJ cord-335975-m6lkrehi 141 56 respiratory respiratory JJ cord-335975-m6lkrehi 141 57 distress distress NN cord-335975-m6lkrehi 141 58 syndrome syndrome NN cord-335975-m6lkrehi 141 59 ( ( -LRB- cord-335975-m6lkrehi 141 60 ARDS ARDS NNP cord-335975-m6lkrehi 141 61 ) ) -RRB- cord-335975-m6lkrehi 141 62 to to TO cord-335975-m6lkrehi 141 63 minimize minimize VB cord-335975-m6lkrehi 141 64 additional additional JJ cord-335975-m6lkrehi 141 65 injuries injury NNS cord-335975-m6lkrehi 141 66 to to IN cord-335975-m6lkrehi 141 67 the the DT cord-335975-m6lkrehi 141 68 lung lung NN cord-335975-m6lkrehi 141 69 . . . cord-335975-m6lkrehi 142 1 However however RB cord-335975-m6lkrehi 142 2 , , , cord-335975-m6lkrehi 142 3 increased increase VBN cord-335975-m6lkrehi 142 4 right right RB cord-335975-m6lkrehi 142 5 ventricular ventricular NN cord-335975-m6lkrehi 142 6 ( ( -LRB- cord-335975-m6lkrehi 142 7 RV rv NN cord-335975-m6lkrehi 142 8 ) ) -RRB- cord-335975-m6lkrehi 142 9 afterload afterload NN cord-335975-m6lkrehi 142 10 resulting result VBG cord-335975-m6lkrehi 142 11 from from IN cord-335975-m6lkrehi 142 12 ARDS ARDS NNP cord-335975-m6lkrehi 142 13 could could MD cord-335975-m6lkrehi 142 14 be be VB cord-335975-m6lkrehi 142 15 enhanced enhance VBN cord-335975-m6lkrehi 142 16 by by IN cord-335975-m6lkrehi 142 17 hypercapnic hypercapnic NNP cord-335975-m6lkrehi 142 18 acidosis acidosis NN cord-335975-m6lkrehi 142 19 resulting result VBG cord-335975-m6lkrehi 142 20 from from IN cord-335975-m6lkrehi 142 21 ventilation ventilation NN cord-335975-m6lkrehi 142 22 at at IN cord-335975-m6lkrehi 142 23 lower low JJR cord-335975-m6lkrehi 142 24 tidal tidal JJ cord-335975-m6lkrehi 142 25 volume volume NN cord-335975-m6lkrehi 142 26 . . . cord-335975-m6lkrehi 143 1 Relative relative JJ cord-335975-m6lkrehi 143 2 contribution contribution NN cord-335975-m6lkrehi 143 3 of of IN cord-335975-m6lkrehi 143 4 these these DT cord-335975-m6lkrehi 143 5 factors factor NNS cord-335975-m6lkrehi 143 6 ( ( -LRB- cord-335975-m6lkrehi 143 7 ARDS ARDS NNP cord-335975-m6lkrehi 143 8 and and CC cord-335975-m6lkrehi 143 9 PLV PLV NNP cord-335975-m6lkrehi 143 10 ) ) -RRB- cord-335975-m6lkrehi 143 11 in in IN cord-335975-m6lkrehi 143 12 RV rv NN cord-335975-m6lkrehi 143 13 afterload afterload NN cord-335975-m6lkrehi 143 14 is be VBZ cord-335975-m6lkrehi 143 15 not not RB cord-335975-m6lkrehi 143 16 clearly clearly RB cord-335975-m6lkrehi 143 17 established establish VBN cord-335975-m6lkrehi 143 18 . . . cord-335975-m6lkrehi 144 1 The the DT cord-335975-m6lkrehi 144 2 aim aim NN cord-335975-m6lkrehi 144 3 of of IN cord-335975-m6lkrehi 144 4 this this DT cord-335975-m6lkrehi 144 5 study study NN cord-335975-m6lkrehi 144 6 was be VBD cord-335975-m6lkrehi 144 7 to to TO cord-335975-m6lkrehi 144 8 compare compare VB cord-335975-m6lkrehi 144 9 RV RV NNP cord-335975-m6lkrehi 144 10 afterload afterload NN cord-335975-m6lkrehi 144 11 in in IN cord-335975-m6lkrehi 144 12 ARDS ARDS NNP cord-335975-m6lkrehi 144 13 combined combine VBN cord-335975-m6lkrehi 144 14 with with IN cord-335975-m6lkrehi 144 15 PLV PLV NNP cord-335975-m6lkrehi 144 16 to to IN cord-335975-m6lkrehi 144 17 RV rv NN cord-335975-m6lkrehi 144 18 afterload afterload NN cord-335975-m6lkrehi 144 19 in in IN cord-335975-m6lkrehi 144 20 PLV PLV NNP cord-335975-m6lkrehi 144 21 alone alone RB cord-335975-m6lkrehi 144 22 . . . cord-335975-m6lkrehi 145 1 Patients patient NNS cord-335975-m6lkrehi 145 2 and and CC cord-335975-m6lkrehi 145 3 methods method NNS cord-335975-m6lkrehi 145 4 : : : cord-335975-m6lkrehi 145 5 This this DT cord-335975-m6lkrehi 145 6 study study NN cord-335975-m6lkrehi 145 7 was be VBD cord-335975-m6lkrehi 145 8 performed perform VBN cord-335975-m6lkrehi 145 9 in in IN cord-335975-m6lkrehi 145 10 an an DT cord-335975-m6lkrehi 145 11 experimental experimental JJ cord-335975-m6lkrehi 145 12 model model NN cord-335975-m6lkrehi 145 13 of of IN cord-335975-m6lkrehi 145 14 severe severe JJ cord-335975-m6lkrehi 145 15 hypercapnic hypercapnic NNP cord-335975-m6lkrehi 145 16 acidosis acidosis NN cord-335975-m6lkrehi 145 17 performed perform VBN cord-335975-m6lkrehi 145 18 in in IN cord-335975-m6lkrehi 145 19 2 2 CD cord-335975-m6lkrehi 145 20 series series NN cord-335975-m6lkrehi 145 21 of of IN cord-335975-m6lkrehi 145 22 6 6 CD cord-335975-m6lkrehi 145 23 pigs pig NNS cord-335975-m6lkrehi 145 24 . . . cord-335975-m6lkrehi 146 1 In in IN cord-335975-m6lkrehi 146 2 both both DT cord-335975-m6lkrehi 146 3 groups group NNS cord-335975-m6lkrehi 146 4 , , , cord-335975-m6lkrehi 146 5 respiratory respiratory JJ cord-335975-m6lkrehi 146 6 tidal tidal JJ cord-335975-m6lkrehi 146 7 volume volume NN cord-335975-m6lkrehi 146 8 was be VBD cord-335975-m6lkrehi 146 9 decreased decrease VBN cord-335975-m6lkrehi 146 10 by by IN cord-335975-m6lkrehi 146 11 60 60 CD cord-335975-m6lkrehi 146 12 % % NN cord-335975-m6lkrehi 146 13 . . . cord-335975-m6lkrehi 147 1 In in IN cord-335975-m6lkrehi 147 2 the the DT cord-335975-m6lkrehi 147 3 first first JJ cord-335975-m6lkrehi 147 4 group group NN cord-335975-m6lkrehi 147 5 ( ( -LRB- cord-335975-m6lkrehi 147 6 ARDS ARDS NNP cord-335975-m6lkrehi 147 7 group group NN cord-335975-m6lkrehi 147 8 ) ) -RRB- cord-335975-m6lkrehi 147 9 , , , cord-335975-m6lkrehi 147 10 an an DT cord-335975-m6lkrehi 147 11 ARDS ARDS NNP cord-335975-m6lkrehi 147 12 ( ( -LRB- cord-335975-m6lkrehi 147 13 obtained obtain VBN cord-335975-m6lkrehi 147 14 by by IN cord-335975-m6lkrehi 147 15 repeated repeat VBN cord-335975-m6lkrehi 147 16 bronchoalveolar bronchoalveolar NNP cord-335975-m6lkrehi 147 17 lavage lavage NN cord-335975-m6lkrehi 147 18 ) ) -RRB- cord-335975-m6lkrehi 147 19 was be VBD cord-335975-m6lkrehi 147 20 performed perform VBN cord-335975-m6lkrehi 147 21 before before IN cord-335975-m6lkrehi 147 22 reducing reduce VBG cord-335975-m6lkrehi 147 23 ventilation ventilation NN cord-335975-m6lkrehi 147 24 , , , cord-335975-m6lkrehi 147 25 while while IN cord-335975-m6lkrehi 147 26 in in IN cord-335975-m6lkrehi 147 27 the the DT cord-335975-m6lkrehi 147 28 second second JJ cord-335975-m6lkrehi 147 29 group group NN cord-335975-m6lkrehi 147 30 ( ( -LRB- cord-335975-m6lkrehi 147 31 control control NNP cord-335975-m6lkrehi 147 32 group group NNP cord-335975-m6lkrehi 147 33 ) ) -RRB- cord-335975-m6lkrehi 147 34 , , , cord-335975-m6lkrehi 147 35 hypercapnic hypercapnic NNP cord-335975-m6lkrehi 147 36 acidosis acidosis NN cord-335975-m6lkrehi 147 37 was be VBD cord-335975-m6lkrehi 147 38 resulting result VBG cord-335975-m6lkrehi 147 39 from from IN cord-335975-m6lkrehi 147 40 low low JJ cord-335975-m6lkrehi 147 41 tidal tidal JJ cord-335975-m6lkrehi 147 42 volume volume NN cord-335975-m6lkrehi 147 43 ventilation ventilation NN cord-335975-m6lkrehi 147 44 alone alone RB cord-335975-m6lkrehi 147 45 . . . cord-335975-m6lkrehi 148 1 Results result NNS cord-335975-m6lkrehi 148 2 : : : cord-335975-m6lkrehi 149 1 In in IN cord-335975-m6lkrehi 149 2 both both DT cord-335975-m6lkrehi 149 3 groups group NNS cord-335975-m6lkrehi 149 4 , , , cord-335975-m6lkrehi 149 5 systolic systolic JJ cord-335975-m6lkrehi 149 6 pulmonary pulmonary JJ cord-335975-m6lkrehi 149 7 artery artery NN cord-335975-m6lkrehi 149 8 pressure pressure NN cord-335975-m6lkrehi 149 9 ( ( -LRB- cord-335975-m6lkrehi 149 10 PAPs pap NNS cord-335975-m6lkrehi 149 11 ) ) -RRB- cord-335975-m6lkrehi 149 12 significantly significantly RB cord-335975-m6lkrehi 149 13 increased increase VBD cord-335975-m6lkrehi 149 14 during during IN cord-335975-m6lkrehi 149 15 PLV PLV NNP cord-335975-m6lkrehi 149 16 . . . cord-335975-m6lkrehi 150 1 This this DT cord-335975-m6lkrehi 150 2 increase increase NN cord-335975-m6lkrehi 150 3 was be VBD cord-335975-m6lkrehi 150 4 significantly significantly RB cord-335975-m6lkrehi 150 5 higher high JJR cord-335975-m6lkrehi 150 6 in in IN cord-335975-m6lkrehi 150 7 ARDS ARDS NNP cord-335975-m6lkrehi 150 8 group group NN cord-335975-m6lkrehi 150 9 than than IN cord-335975-m6lkrehi 150 10 in in IN cord-335975-m6lkrehi 150 11 control control NN cord-335975-m6lkrehi 150 12 group group NN cord-335975-m6lkrehi 150 13 ( ( -LRB- cord-335975-m6lkrehi 150 14 Fig Fig NNP cord-335975-m6lkrehi 150 15 . . . cord-335975-m6lkrehi 150 16 1 1 CD cord-335975-m6lkrehi 150 17 ) ) -RRB- cord-335975-m6lkrehi 150 18 . . . cord-335975-m6lkrehi 151 1 Severe severe JJ cord-335975-m6lkrehi 151 2 hypercapnic hypercapnic NNP cord-335975-m6lkrehi 151 3 acidosis acidosis NN cord-335975-m6lkrehi 151 4 occurred occur VBD cord-335975-m6lkrehi 151 5 in in IN cord-335975-m6lkrehi 151 6 both both DT cord-335975-m6lkrehi 151 7 groups group NNS cord-335975-m6lkrehi 151 8 : : : cord-335975-m6lkrehi 152 1 PaCO2 paco2 CD cord-335975-m6lkrehi 152 2 increased increase VBD cord-335975-m6lkrehi 152 3 from from IN cord-335975-m6lkrehi 152 4 41.7 41.7 CD cord-335975-m6lkrehi 152 5 ± ± CD cord-335975-m6lkrehi 152 6 3.6 3.6 CD cord-335975-m6lkrehi 152 7 to to IN cord-335975-m6lkrehi 152 8 78.6 78.6 CD cord-335975-m6lkrehi 152 9 ± ± NNP cord-335975-m6lkrehi 152 10 8.1 8.1 CD cord-335975-m6lkrehi 152 11 ( ( -LRB- cord-335975-m6lkrehi 152 12 p p NN cord-335975-m6lkrehi 152 13 < < XX cord-335975-m6lkrehi 152 14 0.01 0.01 CD cord-335975-m6lkrehi 152 15 ) ) -RRB- cord-335975-m6lkrehi 152 16 and and CC cord-335975-m6lkrehi 152 17 arterial arterial JJ cord-335975-m6lkrehi 152 18 pH pH NNP cord-335975-m6lkrehi 152 19 decreased decrease VBD cord-335975-m6lkrehi 152 20 from from IN cord-335975-m6lkrehi 152 21 7.44 7.44 CD cord-335975-m6lkrehi 152 22 ± ± CD cord-335975-m6lkrehi 152 23 0.05 0.05 CD cord-335975-m6lkrehi 152 24 to to IN cord-335975-m6lkrehi 152 25 7.13 7.13 CD cord-335975-m6lkrehi 152 26 ± ± CD cord-335975-m6lkrehi 152 27 0.04 0.04 CD cord-335975-m6lkrehi 153 1 ( ( -LRB- cord-335975-m6lkrehi 153 2 p p NN cord-335975-m6lkrehi 153 3 < < XX cord-335975-m6lkrehi 153 4 0.01 0.01 CD cord-335975-m6lkrehi 153 5 ) ) -RRB- cord-335975-m6lkrehi 153 6 in in IN cord-335975-m6lkrehi 153 7 ARDS ARDS NNP cord-335975-m6lkrehi 153 8 group group NN cord-335975-m6lkrehi 153 9 while while IN cord-335975-m6lkrehi 153 10 PaCO2 PaCO2 NNP cord-335975-m6lkrehi 153 11 increased increase VBD cord-335975-m6lkrehi 153 12 from from IN cord-335975-m6lkrehi 153 13 37.7 37.7 CD cord-335975-m6lkrehi 153 14 ± ± CD cord-335975-m6lkrehi 153 15 9.4 9.4 CD cord-335975-m6lkrehi 153 16 to to IN cord-335975-m6lkrehi 153 17 93.6 93.6 CD cord-335975-m6lkrehi 153 18 ± ± CD cord-335975-m6lkrehi 153 19 6.4 6.4 CD cord-335975-m6lkrehi 154 1 ( ( -LRB- cord-335975-m6lkrehi 154 2 p p NN cord-335975-m6lkrehi 154 3 < < XX cord-335975-m6lkrehi 154 4 0.01 0.01 CD cord-335975-m6lkrehi 154 5 ) ) -RRB- cord-335975-m6lkrehi 155 1 and and CC cord-335975-m6lkrehi 155 2 arterial arterial JJ cord-335975-m6lkrehi 155 3 pH pH NNP cord-335975-m6lkrehi 155 4 decreased decrease VBD cord-335975-m6lkrehi 155 5 from from IN cord-335975-m6lkrehi 155 6 7.48 7.48 CD cord-335975-m6lkrehi 155 7 ± ± CD cord-335975-m6lkrehi 155 8 0.05 0.05 CD cord-335975-m6lkrehi 155 9 to to IN cord-335975-m6lkrehi 155 10 7.11 7.11 CD cord-335975-m6lkrehi 155 11 ± ± CD cord-335975-m6lkrehi 155 12 0.04 0.04 CD cord-335975-m6lkrehi 156 1 ( ( -LRB- cord-335975-m6lkrehi 156 2 p p NN cord-335975-m6lkrehi 156 3 < < XX cord-335975-m6lkrehi 156 4 0.01 0.01 CD cord-335975-m6lkrehi 156 5 ) ) -RRB- cord-335975-m6lkrehi 156 6 in in IN cord-335975-m6lkrehi 156 7 control control NN cord-335975-m6lkrehi 156 8 group group NN cord-335975-m6lkrehi 156 9 . . . cord-335975-m6lkrehi 157 1 PaO2 PaO2 NNS cord-335975-m6lkrehi 157 2 significantly significantly RB cord-335975-m6lkrehi 157 3 decreased decrease VBD cord-335975-m6lkrehi 157 4 in in IN cord-335975-m6lkrehi 157 5 ARDS ARDS NNP cord-335975-m6lkrehi 157 6 group group NN cord-335975-m6lkrehi 157 7 ( ( -LRB- cord-335975-m6lkrehi 157 8 178 178 CD cord-335975-m6lkrehi 157 9 ± ± CD cord-335975-m6lkrehi 157 10 42 42 CD cord-335975-m6lkrehi 157 11 to to IN cord-335975-m6lkrehi 157 12 54 54 CD cord-335975-m6lkrehi 157 13 ± ± CD cord-335975-m6lkrehi 157 14 12.3 12.3 CD cord-335975-m6lkrehi 157 15 mmHg mmHg NNS cord-335975-m6lkrehi 157 16 , , , cord-335975-m6lkrehi 157 17 p p NN cord-335975-m6lkrehi 157 18 < < XX cord-335975-m6lkrehi 157 19 0.01 0.01 CD cord-335975-m6lkrehi 157 20 ) ) -RRB- cord-335975-m6lkrehi 157 21 but but CC cord-335975-m6lkrehi 157 22 did do VBD cord-335975-m6lkrehi 157 23 not not RB cord-335975-m6lkrehi 157 24 significantly significantly RB cord-335975-m6lkrehi 157 25 changed change VBN cord-335975-m6lkrehi 157 26 in in IN cord-335975-m6lkrehi 157 27 control control NN cord-335975-m6lkrehi 157 28 group group NN cord-335975-m6lkrehi 157 29 . . . cord-335975-m6lkrehi 158 1 Conclusion conclusion NN cord-335975-m6lkrehi 158 2 : : : cord-335975-m6lkrehi 159 1 Isolated isolated JJ cord-335975-m6lkrehi 159 2 hypercapnic hypercapnic NNP cord-335975-m6lkrehi 159 3 acidosis acidosis NN cord-335975-m6lkrehi 159 4 resulting result VBG cord-335975-m6lkrehi 159 5 from from IN cord-335975-m6lkrehi 159 6 PLV PLV NNP cord-335975-m6lkrehi 159 7 was be VBD cord-335975-m6lkrehi 159 8 clearly clearly RB cord-335975-m6lkrehi 159 9 responsible responsible JJ cord-335975-m6lkrehi 159 10 for for IN cord-335975-m6lkrehi 159 11 increased increase VBN cord-335975-m6lkrehi 159 12 RV rv NN cord-335975-m6lkrehi 159 13 afterload afterload NN cord-335975-m6lkrehi 159 14 and and CC cord-335975-m6lkrehi 159 15 this this DT cord-335975-m6lkrehi 159 16 effect effect NN cord-335975-m6lkrehi 159 17 was be VBD cord-335975-m6lkrehi 159 18 significantly significantly RB cord-335975-m6lkrehi 159 19 enhanced enhance VBN cord-335975-m6lkrehi 159 20 in in IN cord-335975-m6lkrehi 159 21 ARDS ARDS NNP cord-335975-m6lkrehi 159 22 . . . cord-335975-m6lkrehi 160 1 Pulmonary pulmonary JJ cord-335975-m6lkrehi 160 2 vasoconstriction vasoconstriction NN cord-335975-m6lkrehi 160 3 resulting result VBG cord-335975-m6lkrehi 160 4 from from IN cord-335975-m6lkrehi 160 5 hypercapnic hypercapnic NNP cord-335975-m6lkrehi 160 6 acidosis acidosis NN cord-335975-m6lkrehi 160 7 is be VBZ cord-335975-m6lkrehi 160 8 strongly strongly RB cord-335975-m6lkrehi 160 9 enhanced enhance VBN cord-335975-m6lkrehi 160 10 by by IN cord-335975-m6lkrehi 160 11 factors factor NNS cord-335975-m6lkrehi 160 12 like like IN cord-335975-m6lkrehi 160 13 hypoxia hypoxia NN cord-335975-m6lkrehi 160 14 , , , cord-335975-m6lkrehi 160 15 endothelial endothelial JJ cord-335975-m6lkrehi 160 16 injuries injury NNS cord-335975-m6lkrehi 160 17 or or CC cord-335975-m6lkrehi 160 18 inflammatory inflammatory JJ cord-335975-m6lkrehi 160 19 mediators mediator NNS cord-335975-m6lkrehi 160 20 in in IN cord-335975-m6lkrehi 160 21 ARDS ARDS NNP cord-335975-m6lkrehi 160 22 . . . cord-335975-m6lkrehi 161 1 Extracorporeal extracorporeal NN cord-335975-m6lkrehi 161 2 CO CO NNP cord-335975-m6lkrehi 161 3 2 2 CD cord-335975-m6lkrehi 161 4 removal removal NN cord-335975-m6lkrehi 161 5 could could MD cord-335975-m6lkrehi 161 6 be be VB cord-335975-m6lkrehi 161 7 the the DT cord-335975-m6lkrehi 161 8 solution solution NN cord-335975-m6lkrehi 161 9 to to TO cord-335975-m6lkrehi 161 10 limit limit VB cord-335975-m6lkrehi 161 11 afterload afterload NN cord-335975-m6lkrehi 161 12 burden burden NN cord-335975-m6lkrehi 161 13 on on IN cord-335975-m6lkrehi 161 14 the the DT cord-335975-m6lkrehi 161 15 right right JJ cord-335975-m6lkrehi 161 16 ventricle ventricle NN cord-335975-m6lkrehi 161 17 when when WRB cord-335975-m6lkrehi 161 18 PLV PLV NNP cord-335975-m6lkrehi 161 19 is be VBZ cord-335975-m6lkrehi 161 20 achieved achieve VBN cord-335975-m6lkrehi 161 21 during during IN cord-335975-m6lkrehi 161 22 ARDS ARDS NNP cord-335975-m6lkrehi 161 23 . . . cord-335975-m6lkrehi 162 1 Introduction introduction NN cord-335975-m6lkrehi 162 2 : : : cord-335975-m6lkrehi 163 1 Prone prone JJ cord-335975-m6lkrehi 163 2 positioning positioning NN cord-335975-m6lkrehi 163 3 has have VBZ cord-335975-m6lkrehi 163 4 been be VBN cord-335975-m6lkrehi 163 5 shown show VBN cord-335975-m6lkrehi 163 6 to to TO cord-335975-m6lkrehi 163 7 improve improve VB cord-335975-m6lkrehi 163 8 mortality mortality NN cord-335975-m6lkrehi 163 9 in in IN cord-335975-m6lkrehi 163 10 acute acute JJ cord-335975-m6lkrehi 163 11 respiratory respiratory JJ cord-335975-m6lkrehi 163 12 distress distress NN cord-335975-m6lkrehi 163 13 syndrome syndrome NN cord-335975-m6lkrehi 163 14 ( ( -LRB- cord-335975-m6lkrehi 163 15 ARDS ARDS NNP cord-335975-m6lkrehi 163 16 ) ) -RRB- cord-335975-m6lkrehi 163 17 patients patient NNS cord-335975-m6lkrehi 163 18 . . . cord-335975-m6lkrehi 164 1 The the DT cord-335975-m6lkrehi 164 2 respiratory respiratory JJ cord-335975-m6lkrehi 164 3 system system NN cord-335975-m6lkrehi 164 4 driving driving NN cord-335975-m6lkrehi 164 5 - - HYPH cord-335975-m6lkrehi 164 6 pressure pressure NN cord-335975-m6lkrehi 164 7 ( ( -LRB- cord-335975-m6lkrehi 164 8 DPRS DPRS NNP cord-335975-m6lkrehi 164 9 ) ) -RRB- cord-335975-m6lkrehi 164 10 and and CC cord-335975-m6lkrehi 164 11 the the DT cord-335975-m6lkrehi 164 12 transpulmonary transpulmonary JJ cord-335975-m6lkrehi 164 13 driving drive VBG cord-335975-m6lkrehi 164 14 - - HYPH cord-335975-m6lkrehi 164 15 pressure pressure NN cord-335975-m6lkrehi 164 16 ( ( -LRB- cord-335975-m6lkrehi 164 17 DPL DPL NNP cord-335975-m6lkrehi 164 18 ) ) -RRB- cord-335975-m6lkrehi 164 19 , , , cord-335975-m6lkrehi 164 20 measured measure VBN cord-335975-m6lkrehi 164 21 with with IN cord-335975-m6lkrehi 164 22 esophageal esophageal JJ cord-335975-m6lkrehi 164 23 manometry manometry NNP cord-335975-m6lkrehi 164 24 , , , cord-335975-m6lkrehi 164 25 have have VBP cord-335975-m6lkrehi 164 26 been be VBN cord-335975-m6lkrehi 164 27 shown show VBN cord-335975-m6lkrehi 164 28 to to TO cord-335975-m6lkrehi 164 29 be be VB cord-335975-m6lkrehi 164 30 strongly strongly RB cord-335975-m6lkrehi 164 31 correlated correlate VBN cord-335975-m6lkrehi 164 32 with with IN cord-335975-m6lkrehi 164 33 mortality mortality NN cord-335975-m6lkrehi 164 34 . . . cord-335975-m6lkrehi 165 1 The the DT cord-335975-m6lkrehi 165 2 aim aim NN cord-335975-m6lkrehi 165 3 of of IN cord-335975-m6lkrehi 165 4 this this DT cord-335975-m6lkrehi 165 5 study study NN cord-335975-m6lkrehi 165 6 was be VBD cord-335975-m6lkrehi 165 7 to to TO cord-335975-m6lkrehi 165 8 investigate investigate VB cord-335975-m6lkrehi 165 9 the the DT cord-335975-m6lkrehi 165 10 evolution evolution NN cord-335975-m6lkrehi 165 11 of of IN cord-335975-m6lkrehi 165 12 the the DT cord-335975-m6lkrehi 165 13 DPL DPL NNP cord-335975-m6lkrehi 165 14 during during IN cord-335975-m6lkrehi 165 15 prone prone JJ cord-335975-m6lkrehi 165 16 positioning positioning NN cord-335975-m6lkrehi 165 17 and and CC cord-335975-m6lkrehi 165 18 its -PRON- PRP$ cord-335975-m6lkrehi 165 19 relationship relationship NN cord-335975-m6lkrehi 165 20 with with IN cord-335975-m6lkrehi 165 21 evolution evolution NN cord-335975-m6lkrehi 165 22 of of IN cord-335975-m6lkrehi 165 23 oxygenation oxygenation NN cord-335975-m6lkrehi 165 24 in in IN cord-335975-m6lkrehi 165 25 ARDS ARDS NNP cord-335975-m6lkrehi 165 26 patients patient NNS cord-335975-m6lkrehi 165 27 . . . cord-335975-m6lkrehi 166 1 Patients patient NNS cord-335975-m6lkrehi 166 2 and and CC cord-335975-m6lkrehi 166 3 methods method NNS cord-335975-m6lkrehi 166 4 : : : cord-335975-m6lkrehi 166 5 Ten ten CD cord-335975-m6lkrehi 166 6 patients patient NNS cord-335975-m6lkrehi 166 7 with with IN cord-335975-m6lkrehi 166 8 ARDS ARDS NNP cord-335975-m6lkrehi 166 9 equipped equip VBN cord-335975-m6lkrehi 166 10 with with IN cord-335975-m6lkrehi 166 11 esophageal esophageal NN cord-335975-m6lkrehi 166 12 manometry manometry NNP cord-335975-m6lkrehi 166 13 were be VBD cord-335975-m6lkrehi 166 14 enrolled enrol VBN cord-335975-m6lkrehi 166 15 . . . cord-335975-m6lkrehi 167 1 DPRS DPRS NNP cord-335975-m6lkrehi 167 2 , , , cord-335975-m6lkrehi 167 3 DPL DPL NNP cord-335975-m6lkrehi 167 4 and and CC cord-335975-m6lkrehi 167 5 chest chest NN cord-335975-m6lkrehi 167 6 wall wall NN cord-335975-m6lkrehi 167 7 driving driving NN cord-335975-m6lkrehi 167 8 - - HYPH cord-335975-m6lkrehi 167 9 pressure pressure NN cord-335975-m6lkrehi 167 10 ( ( -LRB- cord-335975-m6lkrehi 167 11 DPCW DPCW NNP cord-335975-m6lkrehi 167 12 ) ) -RRB- cord-335975-m6lkrehi 167 13 were be VBD cord-335975-m6lkrehi 167 14 measured measure VBN cord-335975-m6lkrehi 167 15 before before RB cord-335975-m6lkrehi 167 16 and and CC cord-335975-m6lkrehi 167 17 1 1 CD cord-335975-m6lkrehi 167 18 h h NN cord-335975-m6lkrehi 167 19 after after IN cord-335975-m6lkrehi 167 20 prone prone JJ cord-335975-m6lkrehi 167 21 positioning positioning NN cord-335975-m6lkrehi 167 22 . . . cord-335975-m6lkrehi 168 1 Respiratory respiratory JJ cord-335975-m6lkrehi 168 2 system system NN cord-335975-m6lkrehi 168 3 , , , cord-335975-m6lkrehi 168 4 pulmonary pulmonary JJ cord-335975-m6lkrehi 168 5 and and CC cord-335975-m6lkrehi 168 6 chest chest NN cord-335975-m6lkrehi 168 7 wall wall NNP cord-335975-m6lkrehi 168 8 elastance elastance NNP cord-335975-m6lkrehi 168 9 ( ( -LRB- cord-335975-m6lkrehi 168 10 ERS ERS NNP cord-335975-m6lkrehi 168 11 , , , cord-335975-m6lkrehi 168 12 EL EL NNP cord-335975-m6lkrehi 168 13 , , , cord-335975-m6lkrehi 168 14 ECW ECW NNP cord-335975-m6lkrehi 168 15 ) ) -RRB- cord-335975-m6lkrehi 168 16 were be VBD cord-335975-m6lkrehi 168 17 calculated calculate VBN cord-335975-m6lkrehi 168 18 at at IN cord-335975-m6lkrehi 168 19 the the DT cord-335975-m6lkrehi 168 20 same same JJ cord-335975-m6lkrehi 168 21 time time NN cord-335975-m6lkrehi 168 22 . . . cord-335975-m6lkrehi 169 1 Finally finally RB cord-335975-m6lkrehi 169 2 , , , cord-335975-m6lkrehi 169 3 we -PRON- PRP cord-335975-m6lkrehi 169 4 studied study VBD cord-335975-m6lkrehi 169 5 the the DT cord-335975-m6lkrehi 169 6 correlation correlation NN cord-335975-m6lkrehi 169 7 between between IN cord-335975-m6lkrehi 169 8 these these DT cord-335975-m6lkrehi 169 9 respiratory respiratory JJ cord-335975-m6lkrehi 169 10 variables variable NNS cord-335975-m6lkrehi 169 11 and and CC cord-335975-m6lkrehi 169 12 oxygenation oxygenation NN cord-335975-m6lkrehi 169 13 indicators indicator NNS cord-335975-m6lkrehi 169 14 . . . cord-335975-m6lkrehi 170 1 Patients patient NNS cord-335975-m6lkrehi 170 2 were be VBD cord-335975-m6lkrehi 170 3 classified classify VBN cord-335975-m6lkrehi 170 4 as as IN cord-335975-m6lkrehi 170 5 responders responder NNS cord-335975-m6lkrehi 170 6 to to IN cord-335975-m6lkrehi 170 7 prone prone JJ cord-335975-m6lkrehi 170 8 positioning positioning NN cord-335975-m6lkrehi 170 9 if if IN cord-335975-m6lkrehi 170 10 the the DT cord-335975-m6lkrehi 170 11 change change NN cord-335975-m6lkrehi 170 12 in in IN cord-335975-m6lkrehi 170 13 the the DT cord-335975-m6lkrehi 170 14 ratio ratio NN cord-335975-m6lkrehi 170 15 of of IN cord-335975-m6lkrehi 170 16 arterial arterial JJ cord-335975-m6lkrehi 170 17 oxygen oxygen NN cord-335975-m6lkrehi 170 18 partial partial JJ cord-335975-m6lkrehi 170 19 pressure pressure NN cord-335975-m6lkrehi 170 20 oxygen oxygen NN cord-335975-m6lkrehi 170 21 inspired inspire VBN cord-335975-m6lkrehi 170 22 fraction fraction NN cord-335975-m6lkrehi 170 23 ( ( -LRB- cord-335975-m6lkrehi 170 24 Delta Delta NNP cord-335975-m6lkrehi 170 25 . . . cord-335975-m6lkrehi 171 1 PaO2 PaO2 NNPS cord-335975-m6lkrehi 171 2 / / SYM cord-335975-m6lkrehi 171 3 FiO2 FiO2 NNP cord-335975-m6lkrehi 171 4 ) ) -RRB- cord-335975-m6lkrehi 171 5 induced induce VBN cord-335975-m6lkrehi 171 6 by by IN cord-335975-m6lkrehi 171 7 the the DT cord-335975-m6lkrehi 171 8 manoeuvre manoeuvre NN cord-335975-m6lkrehi 171 9 was be VBD cord-335975-m6lkrehi 171 10 larger large JJR cord-335975-m6lkrehi 171 11 than than IN cord-335975-m6lkrehi 171 12 the the DT cord-335975-m6lkrehi 171 13 median median JJ cord-335975-m6lkrehi 171 14 value value NN cord-335975-m6lkrehi 171 15 observed observe VBN cord-335975-m6lkrehi 171 16 in in IN cord-335975-m6lkrehi 171 17 the the DT cord-335975-m6lkrehi 171 18 group group NN cord-335975-m6lkrehi 171 19 . . . cord-335975-m6lkrehi 172 1 Results result NNS cord-335975-m6lkrehi 172 2 : : : cord-335975-m6lkrehi 173 1 In in IN cord-335975-m6lkrehi 173 2 the the DT cord-335975-m6lkrehi 173 3 whole whole JJ cord-335975-m6lkrehi 173 4 population population NN cord-335975-m6lkrehi 173 5 , , , cord-335975-m6lkrehi 173 6 median median JJ cord-335975-m6lkrehi 173 7 value value NN cord-335975-m6lkrehi 173 8 of of IN cord-335975-m6lkrehi 173 9 Delta Delta NNP cord-335975-m6lkrehi 173 10 . . . cord-335975-m6lkrehi 174 1 PaO2 PaO2 NNPS cord-335975-m6lkrehi 174 2 / / SYM cord-335975-m6lkrehi 174 3 FiO2 FiO2 NNS cord-335975-m6lkrehi 174 4 was be VBD cord-335975-m6lkrehi 174 5 53.5 53.5 CD cord-335975-m6lkrehi 174 6 mmHg mmHg NNS cord-335975-m6lkrehi 174 7 , , , cord-335975-m6lkrehi 174 8 and and CC cord-335975-m6lkrehi 174 9 5 5 CD cord-335975-m6lkrehi 174 10 patients patient NNS cord-335975-m6lkrehi 174 11 were be VBD cord-335975-m6lkrehi 174 12 classified classify VBN cord-335975-m6lkrehi 174 13 as as IN cord-335975-m6lkrehi 174 14 responders responder NNS cord-335975-m6lkrehi 174 15 and and CC cord-335975-m6lkrehi 174 16 5 5 CD cord-335975-m6lkrehi 174 17 as as IN cord-335975-m6lkrehi 174 18 non non NNS cord-335975-m6lkrehi 174 19 - - NNS cord-335975-m6lkrehi 174 20 responders responder NNS cord-335975-m6lkrehi 174 21 . . . cord-335975-m6lkrehi 175 1 In in IN cord-335975-m6lkrehi 175 2 responders responder NNS cord-335975-m6lkrehi 175 3 , , , cord-335975-m6lkrehi 175 4 DPL DPL NNP cord-335975-m6lkrehi 175 5 significantly significantly RB cord-335975-m6lkrehi 175 6 decreased decrease VBD cord-335975-m6lkrehi 175 7 from from IN cord-335975-m6lkrehi 175 8 8.8 8.8 CD cord-335975-m6lkrehi 175 9 ± ± NNP cord-335975-m6lkrehi 175 10 4.1 4.1 CD cord-335975-m6lkrehi 175 11 cm cm NN cord-335975-m6lkrehi 175 12 H h NN cord-335975-m6lkrehi 175 13 2 2 CD cord-335975-m6lkrehi 175 14 O o NN cord-335975-m6lkrehi 175 15 to to IN cord-335975-m6lkrehi 175 16 5.9 5.9 CD cord-335975-m6lkrehi 175 17 ± ± CD cord-335975-m6lkrehi 175 18 5.4 5.4 CD cord-335975-m6lkrehi 175 19 cm cm NN cord-335975-m6lkrehi 175 20 H h NN cord-335975-m6lkrehi 175 21 2 2 CD cord-335975-m6lkrehi 175 22 O o NN cord-335975-m6lkrehi 175 23 ( ( -LRB- cord-335975-m6lkrehi 175 24 p p NN cord-335975-m6lkrehi 175 25 = = SYM cord-335975-m6lkrehi 175 26 0.02 0.02 CD cord-335975-m6lkrehi 175 27 ) ) -RRB- cord-335975-m6lkrehi 176 1 and and CC cord-335975-m6lkrehi 176 2 EL EL NNP cord-335975-m6lkrehi 176 3 decreased decrease VBD cord-335975-m6lkrehi 176 4 from from IN cord-335975-m6lkrehi 176 5 21.9 21.9 CD cord-335975-m6lkrehi 177 1 ± ± NNP cord-335975-m6lkrehi 177 2 5.1 5.1 CD cord-335975-m6lkrehi 177 3 cm cm NN cord-335975-m6lkrehi 177 4 H h NN cord-335975-m6lkrehi 177 5 2 2 NN cord-335975-m6lkrehi 177 6 O o NN cord-335975-m6lkrehi 177 7 L l NN cord-335975-m6lkrehi 178 1 to to IN cord-335975-m6lkrehi 178 2 14.9 14.9 CD cord-335975-m6lkrehi 178 3 ± ± NNP cord-335975-m6lkrehi 178 4 6.5 6.5 CD cord-335975-m6lkrehi 178 5 cm cm NN cord-335975-m6lkrehi 178 6 H h NN cord-335975-m6lkrehi 178 7 2 2 CD cord-335975-m6lkrehi 178 8 O o NN cord-335975-m6lkrehi 178 9 L l NN cord-335975-m6lkrehi 178 10 ( ( -LRB- cord-335975-m6lkrehi 178 11 p p NN cord-335975-m6lkrehi 178 12 = = SYM cord-335975-m6lkrehi 178 13 0.02 0.02 CD cord-335975-m6lkrehi 178 14 ) ) -RRB- cord-335975-m6lkrehi 178 15 after after IN cord-335975-m6lkrehi 178 16 prone prone JJ cord-335975-m6lkrehi 178 17 positioning positioning NN cord-335975-m6lkrehi 178 18 . . . cord-335975-m6lkrehi 179 1 Other other JJ cord-335975-m6lkrehi 179 2 respiratory respiratory JJ cord-335975-m6lkrehi 179 3 variables variable NNS cord-335975-m6lkrehi 179 4 did do VBD cord-335975-m6lkrehi 179 5 not not RB cord-335975-m6lkrehi 179 6 change change VB cord-335975-m6lkrehi 179 7 . . . cord-335975-m6lkrehi 180 1 In in IN cord-335975-m6lkrehi 180 2 non non JJ cord-335975-m6lkrehi 180 3 - - NNS cord-335975-m6lkrehi 180 4 responders responder NNS cord-335975-m6lkrehi 180 5 , , , cord-335975-m6lkrehi 180 6 respiratory respiratory JJ cord-335975-m6lkrehi 180 7 variables variable NNS cord-335975-m6lkrehi 180 8 did do VBD cord-335975-m6lkrehi 180 9 not not RB cord-335975-m6lkrehi 180 10 change change VB cord-335975-m6lkrehi 180 11 . . . cord-335975-m6lkrehi 181 1 Between between IN cord-335975-m6lkrehi 181 2 responders responder NNS cord-335975-m6lkrehi 181 3 and and CC cord-335975-m6lkrehi 181 4 nonresponders nonresponder NNS cord-335975-m6lkrehi 181 5 , , , cord-335975-m6lkrehi 181 6 there there EX cord-335975-m6lkrehi 181 7 was be VBD cord-335975-m6lkrehi 181 8 no no DT cord-335975-m6lkrehi 181 9 significant significant JJ cord-335975-m6lkrehi 181 10 difference difference NN cord-335975-m6lkrehi 181 11 between between IN cord-335975-m6lkrehi 181 12 baseline baseline JJ cord-335975-m6lkrehi 181 13 respiratory respiratory JJ cord-335975-m6lkrehi 181 14 variables variable NNS cord-335975-m6lkrehi 181 15 . . . cord-335975-m6lkrehi 182 1 After after IN cord-335975-m6lkrehi 182 2 prone prone JJ cord-335975-m6lkrehi 182 3 positioning positioning NN cord-335975-m6lkrehi 182 4 , , , cord-335975-m6lkrehi 182 5 Delta Delta NNP cord-335975-m6lkrehi 182 6 . . . cord-335975-m6lkrehi 183 1 PaO2 PaO2 NNPS cord-335975-m6lkrehi 183 2 / / SYM cord-335975-m6lkrehi 183 3 FiO2 FiO2 NNS cord-335975-m6lkrehi 183 4 was be VBD cord-335975-m6lkrehi 183 5 not not RB cord-335975-m6lkrehi 183 6 related relate VBN cord-335975-m6lkrehi 183 7 to to IN cord-335975-m6lkrehi 183 8 baseline baseline JJ cord-335975-m6lkrehi 183 9 respiratory respiratory JJ cord-335975-m6lkrehi 183 10 parameters parameter NNS cord-335975-m6lkrehi 183 11 . . . cord-335975-m6lkrehi 184 1 On on IN cord-335975-m6lkrehi 184 2 the the DT cord-335975-m6lkrehi 184 3 contrary contrary JJ cord-335975-m6lkrehi 184 4 Delta Delta NNP cord-335975-m6lkrehi 184 5 . . . cord-335975-m6lkrehi 185 1 PaO2 PaO2 NNPS cord-335975-m6lkrehi 185 2 / / SYM cord-335975-m6lkrehi 185 3 FiO2 FiO2 NNS cord-335975-m6lkrehi 185 4 induced induce VBN cord-335975-m6lkrehi 185 5 by by IN cord-335975-m6lkrehi 185 6 prone prone JJ cord-335975-m6lkrehi 185 7 positioning positioning NN cord-335975-m6lkrehi 185 8 was be VBD cord-335975-m6lkrehi 185 9 strongly strongly RB cord-335975-m6lkrehi 185 10 correlated correlate VBN cord-335975-m6lkrehi 185 11 with with IN cord-335975-m6lkrehi 185 12 changes change NNS cord-335975-m6lkrehi 185 13 in in IN cord-335975-m6lkrehi 185 14 DPL DPL NNP cord-335975-m6lkrehi 185 15 ( ( -LRB- cord-335975-m6lkrehi 185 16 r r NN cord-335975-m6lkrehi 185 17 = = SYM cord-335975-m6lkrehi 185 18 − − CD cord-335975-m6lkrehi 185 19 0.70 0.70 CD cord-335975-m6lkrehi 185 20 , , , cord-335975-m6lkrehi 186 1 p p NN cord-335975-m6lkrehi 186 2 = = SYM cord-335975-m6lkrehi 186 3 0.02 0.02 CD cord-335975-m6lkrehi 186 4 ) ) -RRB- cord-335975-m6lkrehi 186 5 and and CC cord-335975-m6lkrehi 186 6 changes change NNS cord-335975-m6lkrehi 186 7 in in IN cord-335975-m6lkrehi 186 8 EL EL NNP cord-335975-m6lkrehi 186 9 ( ( -LRB- cord-335975-m6lkrehi 186 10 r r NN cord-335975-m6lkrehi 186 11 = = SYM cord-335975-m6lkrehi 186 12 − − NNP cord-335975-m6lkrehi 186 13 0.69 0.69 CD cord-335975-m6lkrehi 186 14 , , , cord-335975-m6lkrehi 186 15 p p NN cord-335975-m6lkrehi 186 16 = = SYM cord-335975-m6lkrehi 186 17 0.03 0.03 CD cord-335975-m6lkrehi 186 18 ) ) -RRB- cord-335975-m6lkrehi 186 19 . . . cord-335975-m6lkrehi 187 1 We -PRON- PRP cord-335975-m6lkrehi 187 2 did do VBD cord-335975-m6lkrehi 187 3 not not RB cord-335975-m6lkrehi 187 4 find find VB cord-335975-m6lkrehi 187 5 any any DT cord-335975-m6lkrehi 187 6 correlation correlation NN cord-335975-m6lkrehi 187 7 between between IN cord-335975-m6lkrehi 187 8 Delta Delta NNP cord-335975-m6lkrehi 187 9 . . . cord-335975-m6lkrehi 188 1 PaO2 PaO2 NNPS cord-335975-m6lkrehi 188 2 / / SYM cord-335975-m6lkrehi 188 3 FiO2 FiO2 NNS cord-335975-m6lkrehi 188 4 and and CC cord-335975-m6lkrehi 188 5 changes change NNS cord-335975-m6lkrehi 188 6 in in IN cord-335975-m6lkrehi 188 7 DPCW DPCW NNP cord-335975-m6lkrehi 188 8 or or CC cord-335975-m6lkrehi 188 9 changes change NNS cord-335975-m6lkrehi 188 10 in in IN cord-335975-m6lkrehi 188 11 ECW ECW NNP cord-335975-m6lkrehi 188 12 . . . cord-335975-m6lkrehi 189 1 The the DT cord-335975-m6lkrehi 189 2 correlation correlation NN cord-335975-m6lkrehi 189 3 between between IN cord-335975-m6lkrehi 189 4 Delta Delta NNP cord-335975-m6lkrehi 189 5 . . . cord-335975-m6lkrehi 190 1 PaO2 PaO2 NNPS cord-335975-m6lkrehi 190 2 / / SYM cord-335975-m6lkrehi 190 3 FiO2 FiO2 NNS cord-335975-m6lkrehi 190 4 and and CC cord-335975-m6lkrehi 190 5 changes change NNS cord-335975-m6lkrehi 190 6 in in IN cord-335975-m6lkrehi 190 7 DPRS DPRS NNP cord-335975-m6lkrehi 190 8 ( ( -LRB- cord-335975-m6lkrehi 190 9 r r NN cord-335975-m6lkrehi 190 10 = = NN cord-335975-m6lkrehi 190 11 − − NNP cord-335975-m6lkrehi 190 12 0.56 0.56 CD cord-335975-m6lkrehi 190 13 , , , cord-335975-m6lkrehi 190 14 p p NN cord-335975-m6lkrehi 190 15 = = SYM cord-335975-m6lkrehi 190 16 0.09 0.09 CD cord-335975-m6lkrehi 190 17 ) ) -RRB- cord-335975-m6lkrehi 190 18 and and CC cord-335975-m6lkrehi 190 19 changes change NNS cord-335975-m6lkrehi 190 20 in in IN cord-335975-m6lkrehi 190 21 ERS ERS NNP cord-335975-m6lkrehi 190 22 ( ( -LRB- cord-335975-m6lkrehi 190 23 r r NN cord-335975-m6lkrehi 190 24 = = NN cord-335975-m6lkrehi 190 25 − − CD cord-335975-m6lkrehi 190 26 0.55 0.55 CD cord-335975-m6lkrehi 190 27 , , , cord-335975-m6lkrehi 190 28 p p NN cord-335975-m6lkrehi 190 29 = = SYM cord-335975-m6lkrehi 190 30 0.10 0.10 CD cord-335975-m6lkrehi 190 31 ) ) -RRB- cord-335975-m6lkrehi 190 32 did do VBD cord-335975-m6lkrehi 190 33 not not RB cord-335975-m6lkrehi 190 34 reach reach VB cord-335975-m6lkrehi 190 35 significance significance NN cord-335975-m6lkrehi 190 36 . . . cord-335975-m6lkrehi 191 1 Conclusion conclusion NN cord-335975-m6lkrehi 191 2 : : : cord-335975-m6lkrehi 192 1 In in IN cord-335975-m6lkrehi 192 2 patients patient NNS cord-335975-m6lkrehi 192 3 who who WP cord-335975-m6lkrehi 192 4 respond respond VBP cord-335975-m6lkrehi 192 5 to to IN cord-335975-m6lkrehi 192 6 prone prone JJ cord-335975-m6lkrehi 192 7 positioning positioning NN cord-335975-m6lkrehi 192 8 by by IN cord-335975-m6lkrehi 192 9 the the DT cord-335975-m6lkrehi 192 10 highest high JJS cord-335975-m6lkrehi 192 11 improvement improvement NN cord-335975-m6lkrehi 192 12 in in IN cord-335975-m6lkrehi 192 13 oxygenation oxygenation NN cord-335975-m6lkrehi 192 14 , , , cord-335975-m6lkrehi 192 15 DPL DPL NNP cord-335975-m6lkrehi 192 16 significantly significantly RB cord-335975-m6lkrehi 192 17 decrease decrease VBP cord-335975-m6lkrehi 192 18 after after IN cord-335975-m6lkrehi 192 19 prone prone JJ cord-335975-m6lkrehi 192 20 positioning positioning NN cord-335975-m6lkrehi 192 21 . . . cord-335975-m6lkrehi 193 1 The the DT cord-335975-m6lkrehi 193 2 changes change NNS cord-335975-m6lkrehi 193 3 in in IN cord-335975-m6lkrehi 193 4 DPL DPL NNP cord-335975-m6lkrehi 193 5 and and CC cord-335975-m6lkrehi 193 6 the the DT cord-335975-m6lkrehi 193 7 changes change NNS cord-335975-m6lkrehi 193 8 in in IN cord-335975-m6lkrehi 193 9 EL EL NNP cord-335975-m6lkrehi 193 10 play play VB cord-335975-m6lkrehi 193 11 a a DT cord-335975-m6lkrehi 193 12 major major JJ cord-335975-m6lkrehi 193 13 role role NN cord-335975-m6lkrehi 193 14 in in IN cord-335975-m6lkrehi 193 15 the the DT cord-335975-m6lkrehi 193 16 improvement improvement NN cord-335975-m6lkrehi 193 17 in in IN cord-335975-m6lkrehi 193 18 oxygenation oxygenation NN cord-335975-m6lkrehi 193 19 induced induce VBN cord-335975-m6lkrehi 193 20 by by IN cord-335975-m6lkrehi 193 21 prone prone JJ cord-335975-m6lkrehi 193 22 positioning positioning NN cord-335975-m6lkrehi 193 23 whereas whereas IN cord-335975-m6lkrehi 193 24 the the DT cord-335975-m6lkrehi 193 25 changes change NNS cord-335975-m6lkrehi 193 26 in in IN cord-335975-m6lkrehi 193 27 DPCW DPCW NNP cord-335975-m6lkrehi 193 28 and and CC cord-335975-m6lkrehi 193 29 ECW ECW NNP cord-335975-m6lkrehi 193 30 do do VBP cord-335975-m6lkrehi 193 31 not not RB cord-335975-m6lkrehi 193 32 . . . cord-335975-m6lkrehi 194 1 Introduction introduction NN cord-335975-m6lkrehi 194 2 : : : cord-335975-m6lkrehi 195 1 Whereas whereas IN cord-335975-m6lkrehi 195 2 prone prone JJ cord-335975-m6lkrehi 195 3 positioning positioning NN cord-335975-m6lkrehi 195 4 ( ( -LRB- cord-335975-m6lkrehi 195 5 PP PP NNP cord-335975-m6lkrehi 195 6 ) ) -RRB- cord-335975-m6lkrehi 195 7 has have VBZ cord-335975-m6lkrehi 195 8 been be VBN cord-335975-m6lkrehi 195 9 shown show VBN cord-335975-m6lkrehi 195 10 to to TO cord-335975-m6lkrehi 195 11 improve improve VB cord-335975-m6lkrehi 195 12 patient patient JJ cord-335975-m6lkrehi 195 13 survival survival NN cord-335975-m6lkrehi 195 14 in in IN cord-335975-m6lkrehi 195 15 moderate moderate JJ cord-335975-m6lkrehi 195 16 to to IN cord-335975-m6lkrehi 195 17 severe severe JJ cord-335975-m6lkrehi 195 18 ARDS ARDS NNP cord-335975-m6lkrehi 195 19 patients patient NNS cord-335975-m6lkrehi 195 20 , , , cord-335975-m6lkrehi 195 21 its -PRON- PRP$ cord-335975-m6lkrehi 195 22 rate rate NN cord-335975-m6lkrehi 195 23 of of IN cord-335975-m6lkrehi 195 24 use use NN cord-335975-m6lkrehi 195 25 was be VBD cord-335975-m6lkrehi 195 26 7.4 7.4 CD cord-335975-m6lkrehi 195 27 % % NN cord-335975-m6lkrehi 195 28 in in IN cord-335975-m6lkrehi 195 29 Lung Lung NNP cord-335975-m6lkrehi 195 30 Safe Safe NNP cord-335975-m6lkrehi 195 31 study study NN cord-335975-m6lkrehi 195 32 . . . cord-335975-m6lkrehi 196 1 However however RB cord-335975-m6lkrehi 196 2 , , , cord-335975-m6lkrehi 196 3 Lung Lung NNP cord-335975-m6lkrehi 196 4 Safe safe JJ cord-335975-m6lkrehi 196 5 study study NN cord-335975-m6lkrehi 196 6 was be VBD cord-335975-m6lkrehi 196 7 not not RB cord-335975-m6lkrehi 196 8 specifically specifically RB cord-335975-m6lkrehi 196 9 focused focus VBN cord-335975-m6lkrehi 196 10 on on IN cord-335975-m6lkrehi 196 11 PP PP NNP cord-335975-m6lkrehi 196 12 . . . cord-335975-m6lkrehi 197 1 Therefore therefore RB cord-335975-m6lkrehi 197 2 , , , cord-335975-m6lkrehi 197 3 present present JJ cord-335975-m6lkrehi 197 4 study study NN cord-335975-m6lkrehi 197 5 aimed aim VBN cord-335975-m6lkrehi 197 6 to to TO cord-335975-m6lkrehi 197 7 determine determine VB cord-335975-m6lkrehi 197 8 prevalence prevalence NN cord-335975-m6lkrehi 197 9 of of IN cord-335975-m6lkrehi 197 10 use use NN cord-335975-m6lkrehi 197 11 of of IN cord-335975-m6lkrehi 197 12 PP PP NNP cord-335975-m6lkrehi 197 13 in in IN cord-335975-m6lkrehi 197 14 ARDS ARDS NNP cord-335975-m6lkrehi 197 15 patients patient NNS cord-335975-m6lkrehi 197 16 ( ( -LRB- cord-335975-m6lkrehi 197 17 primary primary JJ cord-335975-m6lkrehi 197 18 endpoint endpoint NN cord-335975-m6lkrehi 197 19 ) ) -RRB- cord-335975-m6lkrehi 197 20 , , , cord-335975-m6lkrehi 197 21 physiologic physiologic JJ cord-335975-m6lkrehi 197 22 effects effect NNS cord-335975-m6lkrehi 197 23 of of IN cord-335975-m6lkrehi 197 24 and and CC cord-335975-m6lkrehi 197 25 reasons reason NNS cord-335975-m6lkrehi 197 26 for for IN cord-335975-m6lkrehi 197 27 not not RB cord-335975-m6lkrehi 197 28 using use VBG cord-335975-m6lkrehi 197 29 PP PP NNP cord-335975-m6lkrehi 197 30 ( ( -LRB- cord-335975-m6lkrehi 197 31 secondary secondary JJ cord-335975-m6lkrehi 197 32 end end NN cord-335975-m6lkrehi 197 33 - - HYPH cord-335975-m6lkrehi 197 34 points point NNS cord-335975-m6lkrehi 197 35 ) ) -RRB- cord-335975-m6lkrehi 197 36 . . . cord-335975-m6lkrehi 198 1 The the DT cord-335975-m6lkrehi 198 2 APRONET APRONET NNP cord-335975-m6lkrehi 198 3 study study NN cord-335975-m6lkrehi 198 4 was be VBD cord-335975-m6lkrehi 198 5 a a DT cord-335975-m6lkrehi 198 6 prospective prospective JJ cord-335975-m6lkrehi 198 7 international international JJ cord-335975-m6lkrehi 198 8 one one CD cord-335975-m6lkrehi 198 9 - - HYPH cord-335975-m6lkrehi 198 10 day day NN cord-335975-m6lkrehi 198 11 prevalence prevalence NN cord-335975-m6lkrehi 198 12 study study NN cord-335975-m6lkrehi 198 13 performed perform VBD cord-335975-m6lkrehi 198 14 4 4 CD cord-335975-m6lkrehi 198 15 times time NNS cord-335975-m6lkrehi 198 16 in in IN cord-335975-m6lkrehi 198 17 April April NNP cord-335975-m6lkrehi 198 18 , , , cord-335975-m6lkrehi 198 19 July July NNP cord-335975-m6lkrehi 198 20 , , , cord-335975-m6lkrehi 198 21 October October NNP cord-335975-m6lkrehi 198 22 2016 2016 CD cord-335975-m6lkrehi 198 23 and and CC cord-335975-m6lkrehi 198 24 January January NNP cord-335975-m6lkrehi 198 25 2017 2017 CD cord-335975-m6lkrehi 198 26 . . . cord-335975-m6lkrehi 199 1 At at IN cord-335975-m6lkrehi 199 2 each each DT cord-335975-m6lkrehi 199 3 study study NN cord-335975-m6lkrehi 199 4 day day NN cord-335975-m6lkrehi 199 5 , , , cord-335975-m6lkrehi 199 6 investigators investigator NNS cord-335975-m6lkrehi 199 7 had have VBD cord-335975-m6lkrehi 199 8 to to TO cord-335975-m6lkrehi 199 9 screen screen VB cord-335975-m6lkrehi 199 10 every every DT cord-335975-m6lkrehi 199 11 patient patient NN cord-335975-m6lkrehi 199 12 staying stay VBG cord-335975-m6lkrehi 199 13 in in IN cord-335975-m6lkrehi 199 14 ICU ICU NNP cord-335975-m6lkrehi 199 15 from from IN cord-335975-m6lkrehi 199 16 0 0 CD cord-335975-m6lkrehi 199 17 to to IN cord-335975-m6lkrehi 199 18 24 24 CD cord-335975-m6lkrehi 199 19 h h NN cord-335975-m6lkrehi 199 20 and and CC cord-335975-m6lkrehi 199 21 to to TO cord-335975-m6lkrehi 199 22 fill fill VB cord-335975-m6lkrehi 199 23 electronic electronic JJ cord-335975-m6lkrehi 199 24 CRF crf NN cord-335975-m6lkrehi 199 25 . . . cord-335975-m6lkrehi 200 1 For for IN cord-335975-m6lkrehi 200 2 patients patient NNS cord-335975-m6lkrehi 200 3 with with IN cord-335975-m6lkrehi 200 4 ARDS ARDS NNP cord-335975-m6lkrehi 200 5 ( ( -LRB- cord-335975-m6lkrehi 200 6 defined define VBN cord-335975-m6lkrehi 200 7 from from IN cord-335975-m6lkrehi 200 8 the the DT cord-335975-m6lkrehi 200 9 Berlin Berlin NNP cord-335975-m6lkrehi 200 10 definition definition NN cord-335975-m6lkrehi 200 11 criteria criterion NNS cord-335975-m6lkrehi 200 12 ) ) -RRB- cord-335975-m6lkrehi 200 13 at at IN cord-335975-m6lkrehi 200 14 each each DT cord-335975-m6lkrehi 200 15 study study NN cord-335975-m6lkrehi 200 16 day day NN cord-335975-m6lkrehi 200 17 oxygenation oxygenation NN cord-335975-m6lkrehi 200 18 and and CC cord-335975-m6lkrehi 200 19 ventilator ventilator NN cord-335975-m6lkrehi 200 20 settings setting NNS cord-335975-m6lkrehi 200 21 were be VBD cord-335975-m6lkrehi 200 22 recorded record VBN cord-335975-m6lkrehi 200 23 . . . cord-335975-m6lkrehi 201 1 For for IN cord-335975-m6lkrehi 201 2 those those DT cord-335975-m6lkrehi 201 3 receiving receive VBG cord-335975-m6lkrehi 201 4 PP PP NNP cord-335975-m6lkrehi 201 5 these these DT cord-335975-m6lkrehi 201 6 variables variable NNS cord-335975-m6lkrehi 201 7 were be VBD cord-335975-m6lkrehi 201 8 recorded record VBN cord-335975-m6lkrehi 201 9 before before IN cord-335975-m6lkrehi 201 10 and and CC cord-335975-m6lkrehi 201 11 at at IN cord-335975-m6lkrehi 201 12 the the DT cord-335975-m6lkrehi 201 13 end end NN cord-335975-m6lkrehi 201 14 of of IN cord-335975-m6lkrehi 201 15 PP PP NNP cord-335975-m6lkrehi 201 16 session session NN cord-335975-m6lkrehi 201 17 . . . cord-335975-m6lkrehi 202 1 The the DT cord-335975-m6lkrehi 202 2 reasons reason NNS cord-335975-m6lkrehi 202 3 for for IN cord-335975-m6lkrehi 202 4 not not RB cord-335975-m6lkrehi 202 5 proning prone VBG cord-335975-m6lkrehi 202 6 were be VBD cord-335975-m6lkrehi 202 7 also also RB cord-335975-m6lkrehi 202 8 collected collect VBN cord-335975-m6lkrehi 202 9 . . . cord-335975-m6lkrehi 203 1 Values value NNS cord-335975-m6lkrehi 203 2 are be VBP cord-335975-m6lkrehi 203 3 presented present VBN cord-335975-m6lkrehi 203 4 as as IN cord-335975-m6lkrehi 203 5 median median JJ cord-335975-m6lkrehi 203 6 ( ( -LRB- cord-335975-m6lkrehi 203 7 1st-3rd 1st-3rd CD cord-335975-m6lkrehi 203 8 quartiles quartile NNS cord-335975-m6lkrehi 203 9 ) ) -RRB- cord-335975-m6lkrehi 203 10 . . . cord-335975-m6lkrehi 204 1 Prevalence prevalence NN cord-335975-m6lkrehi 204 2 rates rate NNS cord-335975-m6lkrehi 204 3 of of IN cord-335975-m6lkrehi 204 4 PP PP NNP cord-335975-m6lkrehi 204 5 were be VBD cord-335975-m6lkrehi 204 6 compared compare VBN cord-335975-m6lkrehi 204 7 by by IN cord-335975-m6lkrehi 204 8 using use VBG cord-335975-m6lkrehi 204 9 Chi Chi NNP cord-335975-m6lkrehi 204 10 square square NN cord-335975-m6lkrehi 204 11 for for IN cord-335975-m6lkrehi 204 12 trend trend NN cord-335975-m6lkrehi 204 13 and and CC cord-335975-m6lkrehi 204 14 groups group NNS cord-335975-m6lkrehi 204 15 were be VBD cord-335975-m6lkrehi 204 16 compared compare VBN cord-335975-m6lkrehi 204 17 with with IN cord-335975-m6lkrehi 204 18 nonparametric nonparametric JJ cord-335975-m6lkrehi 204 19 tests test NNS cord-335975-m6lkrehi 204 20 . . . cord-335975-m6lkrehi 205 1 Introduction introduction NN cord-335975-m6lkrehi 205 2 : : : cord-335975-m6lkrehi 206 1 Although although IN cord-335975-m6lkrehi 206 2 acute acute JJ cord-335975-m6lkrehi 206 3 respiratory respiratory JJ cord-335975-m6lkrehi 206 4 distress distress NN cord-335975-m6lkrehi 206 5 syndrome syndrome NN cord-335975-m6lkrehi 206 6 ( ( -LRB- cord-335975-m6lkrehi 206 7 ARDS ARDS NNP cord-335975-m6lkrehi 206 8 ) ) -RRB- cord-335975-m6lkrehi 206 9 has have VBZ cord-335975-m6lkrehi 206 10 been be VBN cord-335975-m6lkrehi 206 11 largely largely RB cord-335975-m6lkrehi 206 12 focused focus VBN cord-335975-m6lkrehi 206 13 on on IN cord-335975-m6lkrehi 206 14 , , , cord-335975-m6lkrehi 206 15 few few JJ cord-335975-m6lkrehi 206 16 data datum NNS cord-335975-m6lkrehi 206 17 are be VBP cord-335975-m6lkrehi 206 18 available available JJ cord-335975-m6lkrehi 206 19 concerning concern VBG cord-335975-m6lkrehi 206 20 hypoxemia hypoxemia NN cord-335975-m6lkrehi 206 21 independently independently RB cord-335975-m6lkrehi 206 22 of of IN cord-335975-m6lkrehi 206 23 its -PRON- PRP$ cord-335975-m6lkrehi 206 24 cause cause NN cord-335975-m6lkrehi 206 25 in in IN cord-335975-m6lkrehi 206 26 intensive intensive JJ cord-335975-m6lkrehi 206 27 care care NN cord-335975-m6lkrehi 206 28 unit unit NN cord-335975-m6lkrehi 206 29 ( ( -LRB- cord-335975-m6lkrehi 206 30 ICU ICU NNP cord-335975-m6lkrehi 206 31 ) ) -RRB- cord-335975-m6lkrehi 206 32 patients patient NNS cord-335975-m6lkrehi 206 33 . . . cord-335975-m6lkrehi 207 1 A a DT cord-335975-m6lkrehi 207 2 recent recent JJ cord-335975-m6lkrehi 207 3 prevalence prevalence NN cord-335975-m6lkrehi 207 4 - - HYPH cord-335975-m6lkrehi 207 5 point point NN cord-335975-m6lkrehi 207 6 - - HYPH cord-335975-m6lkrehi 207 7 day day NN cord-335975-m6lkrehi 207 8 ( ( -LRB- cord-335975-m6lkrehi 207 9 PPD PPD NNP cord-335975-m6lkrehi 207 10 ) ) -RRB- cord-335975-m6lkrehi 207 11 evaluated evaluate VBD cord-335975-m6lkrehi 207 12 the the DT cord-335975-m6lkrehi 207 13 patterns pattern NNS cord-335975-m6lkrehi 207 14 and and CC cord-335975-m6lkrehi 207 15 outcomes outcome NNS cord-335975-m6lkrehi 207 16 of of IN cord-335975-m6lkrehi 207 17 hypoxemia hypoxemia NN cord-335975-m6lkrehi 207 18 in in IN cord-335975-m6lkrehi 207 19 French french JJ cord-335975-m6lkrehi 207 20 speaking speak VBG cord-335975-m6lkrehi 207 21 ICUs ICUs NNP cord-335975-m6lkrehi 207 22 . . . cord-335975-m6lkrehi 208 1 Here here RB cord-335975-m6lkrehi 208 2 , , , cord-335975-m6lkrehi 208 3 we -PRON- PRP cord-335975-m6lkrehi 208 4 describe describe VBP cord-335975-m6lkrehi 208 5 the the DT cord-335975-m6lkrehi 208 6 main main JJ cord-335975-m6lkrehi 208 7 etiologies etiology NNS cord-335975-m6lkrehi 208 8 , , , cord-335975-m6lkrehi 208 9 management management NN cord-335975-m6lkrehi 208 10 and and CC cord-335975-m6lkrehi 208 11 outcomes outcome NNS cord-335975-m6lkrehi 208 12 of of IN cord-335975-m6lkrehi 208 13 the the DT cord-335975-m6lkrehi 208 14 patients patient NNS cord-335975-m6lkrehi 208 15 of of IN cord-335975-m6lkrehi 208 16 this this DT cord-335975-m6lkrehi 208 17 cohort cohort NN cord-335975-m6lkrehi 208 18 presenting present VBG cord-335975-m6lkrehi 208 19 with with IN cord-335975-m6lkrehi 208 20 severe severe JJ cord-335975-m6lkrehi 208 21 hypoxemia hypoxemia NN cord-335975-m6lkrehi 208 22 . . . cord-335975-m6lkrehi 209 1 Patients patient NNS cord-335975-m6lkrehi 209 2 and and CC cord-335975-m6lkrehi 209 3 methods method NNS cord-335975-m6lkrehi 209 4 : : : cord-335975-m6lkrehi 209 5 A a DT cord-335975-m6lkrehi 209 6 PPD PPD NNP cord-335975-m6lkrehi 209 7 was be VBD cord-335975-m6lkrehi 209 8 conducted conduct VBN cord-335975-m6lkrehi 209 9 among among IN cord-335975-m6lkrehi 209 10 117 117 CD cord-335975-m6lkrehi 209 11 French french JJ cord-335975-m6lkrehi 209 12 speaking speak VBG cord-335975-m6lkrehi 209 13 ICUs ICUs NNP cord-335975-m6lkrehi 209 14 during during IN cord-335975-m6lkrehi 209 15 spring spring NN cord-335975-m6lkrehi 209 16 2016 2016 CD cord-335975-m6lkrehi 209 17 . . . cord-335975-m6lkrehi 210 1 Hypoxemia Hypoxemia NNP cord-335975-m6lkrehi 210 2 was be VBD cord-335975-m6lkrehi 210 3 defined define VBN cord-335975-m6lkrehi 210 4 by by IN cord-335975-m6lkrehi 210 5 a a DT cord-335975-m6lkrehi 210 6 PaO2 PaO2 NNP cord-335975-m6lkrehi 210 7 FiO2 FiO2 NNP cord-335975-m6lkrehi 210 8 ratio ratio NN cord-335975-m6lkrehi 210 9 below below IN cord-335975-m6lkrehi 210 10 300 300 CD cord-335975-m6lkrehi 210 11 . . . cord-335975-m6lkrehi 211 1 We -PRON- PRP cord-335975-m6lkrehi 211 2 analyzed analyze VBD cord-335975-m6lkrehi 211 3 the the DT cord-335975-m6lkrehi 211 4 data datum NNS cord-335975-m6lkrehi 211 5 from from IN cord-335975-m6lkrehi 211 6 patients patient NNS cord-335975-m6lkrehi 211 7 with with IN cord-335975-m6lkrehi 211 8 severe severe JJ cord-335975-m6lkrehi 211 9 hypoxemia hypoxemia NN cord-335975-m6lkrehi 211 10 ( ( -LRB- cord-335975-m6lkrehi 211 11 i.e. i.e. FW cord-335975-m6lkrehi 211 12 with with IN cord-335975-m6lkrehi 211 13 a a DT cord-335975-m6lkrehi 211 14 PaO2 PaO2 NNP cord-335975-m6lkrehi 211 15 FiO2 FiO2 NNS cord-335975-m6lkrehi 211 16 ratio ratio NN cord-335975-m6lkrehi 211 17 < < XX cord-335975-m6lkrehi 211 18 100 100 CD cord-335975-m6lkrehi 211 19 ) ) -RRB- cord-335975-m6lkrehi 211 20 and and CC cord-335975-m6lkrehi 211 21 compared compare VBD cord-335975-m6lkrehi 211 22 their -PRON- PRP$ cord-335975-m6lkrehi 211 23 characteristics characteristic NNS cord-335975-m6lkrehi 211 24 ( ( -LRB- cord-335975-m6lkrehi 211 25 causes cause NNS cord-335975-m6lkrehi 211 26 of of IN cord-335975-m6lkrehi 211 27 hypoxemia hypoxemia NN cord-335975-m6lkrehi 211 28 , , , cord-335975-m6lkrehi 211 29 ventilatory ventilatory JJ cord-335975-m6lkrehi 211 30 and and CC cord-335975-m6lkrehi 211 31 non non JJ cord-335975-m6lkrehi 211 32 - - JJ cord-335975-m6lkrehi 211 33 ventilatory ventilatory JJ cord-335975-m6lkrehi 211 34 management management NN cord-335975-m6lkrehi 211 35 ) ) -RRB- cord-335975-m6lkrehi 211 36 and and CC cord-335975-m6lkrehi 211 37 outcomes outcome NNS cord-335975-m6lkrehi 211 38 to to IN cord-335975-m6lkrehi 211 39 the the DT cord-335975-m6lkrehi 211 40 patients patient NNS cord-335975-m6lkrehi 211 41 with with IN cord-335975-m6lkrehi 211 42 mild mild JJ cord-335975-m6lkrehi 211 43 or or CC cord-335975-m6lkrehi 211 44 moderate moderate JJ cord-335975-m6lkrehi 211 45 hypoxemia hypoxemia NN cord-335975-m6lkrehi 211 46 . . . cord-335975-m6lkrehi 212 1 Results result NNS cord-335975-m6lkrehi 212 2 : : : cord-335975-m6lkrehi 213 1 Among among IN cord-335975-m6lkrehi 213 2 the the DT cord-335975-m6lkrehi 213 3 859 859 CD cord-335975-m6lkrehi 213 4 hypoxemic hypoxemic NNP cord-335975-m6lkrehi 213 5 patients patient NNS cord-335975-m6lkrehi 213 6 the the DT cord-335975-m6lkrehi 213 7 day day NN cord-335975-m6lkrehi 213 8 of of IN cord-335975-m6lkrehi 213 9 the the DT cord-335975-m6lkrehi 213 10 study study NN cord-335975-m6lkrehi 213 11 , , , cord-335975-m6lkrehi 213 12 74 74 CD cord-335975-m6lkrehi 213 13 ( ( -LRB- cord-335975-m6lkrehi 213 14 9 9 CD cord-335975-m6lkrehi 213 15 % % NN cord-335975-m6lkrehi 213 16 ) ) -RRB- cord-335975-m6lkrehi 213 17 had have VBD cord-335975-m6lkrehi 213 18 severe severe JJ cord-335975-m6lkrehi 213 19 hypoxemia hypoxemia NN cord-335975-m6lkrehi 213 20 . . . cord-335975-m6lkrehi 214 1 The the DT cord-335975-m6lkrehi 214 2 main main JJ cord-335975-m6lkrehi 214 3 cause cause NN cord-335975-m6lkrehi 214 4 of of IN cord-335975-m6lkrehi 214 5 hypoxemia hypoxemia NN cord-335975-m6lkrehi 214 6 was be VBD cord-335975-m6lkrehi 214 7 pneumonia pneumonia NN cord-335975-m6lkrehi 214 8 and and CC cord-335975-m6lkrehi 214 9 this this DT cord-335975-m6lkrehi 214 10 diagnosis diagnosis NN cord-335975-m6lkrehi 214 11 was be VBD cord-335975-m6lkrehi 214 12 more more RBR cord-335975-m6lkrehi 214 13 frequent frequent JJ cord-335975-m6lkrehi 214 14 than than IN cord-335975-m6lkrehi 214 15 in in IN cord-335975-m6lkrehi 214 16 mild mild JJ cord-335975-m6lkrehi 214 17 and and CC cord-335975-m6lkrehi 214 18 moderate moderate JJ cord-335975-m6lkrehi 214 19 hypoxemia hypoxemia NN cord-335975-m6lkrehi 214 20 . . . cord-335975-m6lkrehi 215 1 Whereas whereas IN cord-335975-m6lkrehi 215 2 bilateral bilateral JJ cord-335975-m6lkrehi 215 3 radiologic radiologic JJ cord-335975-m6lkrehi 215 4 infiltrates infiltrate NNS cord-335975-m6lkrehi 215 5 were be VBD cord-335975-m6lkrehi 215 6 present present JJ cord-335975-m6lkrehi 215 7 in in IN cord-335975-m6lkrehi 215 8 56 56 CD cord-335975-m6lkrehi 215 9 ( ( -LRB- cord-335975-m6lkrehi 215 10 84.9 84.9 CD cord-335975-m6lkrehi 215 11 % % NN cord-335975-m6lkrehi 215 12 ) ) -RRB- cord-335975-m6lkrehi 215 13 patients patient NNS cord-335975-m6lkrehi 215 14 , , , cord-335975-m6lkrehi 215 15 ARDS ARDS NNP cord-335975-m6lkrehi 215 16 was be VBD cord-335975-m6lkrehi 215 17 diagnosed diagnose VBN cord-335975-m6lkrehi 215 18 by by IN cord-335975-m6lkrehi 215 19 physicians physician NNS cord-335975-m6lkrehi 215 20 in in IN cord-335975-m6lkrehi 215 21 only only RB cord-335975-m6lkrehi 215 22 30 30 CD cord-335975-m6lkrehi 215 23 ( ( -LRB- cord-335975-m6lkrehi 215 24 40.5 40.5 CD cord-335975-m6lkrehi 215 25 % % NN cord-335975-m6lkrehi 215 26 ) ) -RRB- cord-335975-m6lkrehi 215 27 of of IN cord-335975-m6lkrehi 215 28 them -PRON- PRP cord-335975-m6lkrehi 215 29 . . . cord-335975-m6lkrehi 216 1 Invasive invasive JJ cord-335975-m6lkrehi 216 2 mechanical mechanical JJ cord-335975-m6lkrehi 216 3 ventilation ventilation NN cord-335975-m6lkrehi 216 4 ( ( -LRB- cord-335975-m6lkrehi 216 5 MV MV NNP cord-335975-m6lkrehi 216 6 ) ) -RRB- cord-335975-m6lkrehi 216 7 was be VBD cord-335975-m6lkrehi 216 8 used use VBN cord-335975-m6lkrehi 216 9 in in IN cord-335975-m6lkrehi 216 10 55 55 CD cord-335975-m6lkrehi 216 11 ( ( -LRB- cord-335975-m6lkrehi 216 12 74.3 74.3 CD cord-335975-m6lkrehi 216 13 % % NN cord-335975-m6lkrehi 216 14 ) ) -RRB- cord-335975-m6lkrehi 216 15 patients patient NNS cord-335975-m6lkrehi 216 16 . . . cord-335975-m6lkrehi 217 1 High high JJ cord-335975-m6lkrehi 217 2 flow flow NN cord-335975-m6lkrehi 217 3 oxygen oxygen NN cord-335975-m6lkrehi 217 4 was be VBD cord-335975-m6lkrehi 217 5 administered administer VBN cord-335975-m6lkrehi 217 6 in in IN cord-335975-m6lkrehi 217 7 11 11 CD cord-335975-m6lkrehi 217 8 ( ( -LRB- cord-335975-m6lkrehi 217 9 14.9 14.9 CD cord-335975-m6lkrehi 217 10 % % NN cord-335975-m6lkrehi 217 11 ) ) -RRB- cord-335975-m6lkrehi 217 12 of of IN cord-335975-m6lkrehi 217 13 them -PRON- PRP cord-335975-m6lkrehi 217 14 and and CC cord-335975-m6lkrehi 217 15 8 8 CD cord-335975-m6lkrehi 217 16 ( ( -LRB- cord-335975-m6lkrehi 217 17 10.8 10.8 CD cord-335975-m6lkrehi 217 18 % % NN cord-335975-m6lkrehi 217 19 ) ) -RRB- cord-335975-m6lkrehi 217 20 were be VBD cord-335975-m6lkrehi 217 21 under under IN cord-335975-m6lkrehi 217 22 non non JJ cord-335975-m6lkrehi 217 23 - - JJ cord-335975-m6lkrehi 217 24 invasive invasive JJ cord-335975-m6lkrehi 217 25 ventilation ventilation NN cord-335975-m6lkrehi 217 26 ( ( -LRB- cord-335975-m6lkrehi 217 27 NIV NIV NNP cord-335975-m6lkrehi 217 28 ) ) -RRB- cord-335975-m6lkrehi 217 29 the the DT cord-335975-m6lkrehi 217 30 day day NN cord-335975-m6lkrehi 217 31 of of IN cord-335975-m6lkrehi 217 32 the the DT cord-335975-m6lkrehi 217 33 study study NN cord-335975-m6lkrehi 217 34 . . . cord-335975-m6lkrehi 218 1 Median Median NNP cord-335975-m6lkrehi 218 2 Vt Vt NNP cord-335975-m6lkrehi 218 3 was be VBD cord-335975-m6lkrehi 218 4 6.1 6.1 CD cord-335975-m6lkrehi 218 5 ( ( -LRB- cord-335975-m6lkrehi 218 6 4.8 4.8 CD cord-335975-m6lkrehi 218 7 - - SYM cord-335975-m6lkrehi 218 8 6.6 6.6 CD cord-335975-m6lkrehi 218 9 ) ) -RRB- cord-335975-m6lkrehi 219 1 ml ml NNP cord-335975-m6lkrehi 219 2 kg kg NNP cord-335975-m6lkrehi 219 3 of of IN cord-335975-m6lkrehi 219 4 IBW IBW NNP cord-335975-m6lkrehi 219 5 . . . cord-335975-m6lkrehi 220 1 Positive positive JJ cord-335975-m6lkrehi 220 2 end end NN cord-335975-m6lkrehi 220 3 - - HYPH cord-335975-m6lkrehi 220 4 expiratory expiratory NN cord-335975-m6lkrehi 220 5 pressure pressure NN cord-335975-m6lkrehi 220 6 ( ( -LRB- cord-335975-m6lkrehi 220 7 PEEP peep NN cord-335975-m6lkrehi 220 8 ) ) -RRB- cord-335975-m6lkrehi 220 9 was be VBD cord-335975-m6lkrehi 220 10 higher high JJR cord-335975-m6lkrehi 220 11 than than IN cord-335975-m6lkrehi 220 12 in in IN cord-335975-m6lkrehi 220 13 mild mild JJ cord-335975-m6lkrehi 220 14 and and CC cord-335975-m6lkrehi 220 15 moderate moderate JJ cord-335975-m6lkrehi 220 16 hypoxemic hypoxemic JJ cord-335975-m6lkrehi 220 17 patients patient NNS cord-335975-m6lkrehi 220 18 ( ( -LRB- cord-335975-m6lkrehi 220 19 10 10 CD cord-335975-m6lkrehi 220 20 ( ( -LRB- cord-335975-m6lkrehi 220 21 8 8 CD cord-335975-m6lkrehi 220 22 - - SYM cord-335975-m6lkrehi 220 23 12 12 CD cord-335975-m6lkrehi 220 24 ) ) -RRB- cord-335975-m6lkrehi 221 1 vs. vs. FW cord-335975-m6lkrehi 221 2 5 5 CD cord-335975-m6lkrehi 221 3 ( ( -LRB- cord-335975-m6lkrehi 221 4 5 5 CD cord-335975-m6lkrehi 221 5 - - SYM cord-335975-m6lkrehi 221 6 8 8 CD cord-335975-m6lkrehi 221 7 ) ) -RRB- cord-335975-m6lkrehi 221 8 and and CC cord-335975-m6lkrehi 221 9 7 7 CD cord-335975-m6lkrehi 221 10 ( ( -LRB- cord-335975-m6lkrehi 221 11 5 5 CD cord-335975-m6lkrehi 221 12 - - SYM cord-335975-m6lkrehi 221 13 10 10 CD cord-335975-m6lkrehi 221 14 ) ) -RRB- cord-335975-m6lkrehi 221 15 cm cm NN cord-335975-m6lkrehi 221 16 H h NN cord-335975-m6lkrehi 221 17 2 2 CD cord-335975-m6lkrehi 221 18 O o NN cord-335975-m6lkrehi 221 19 respectively respectively RB cord-335975-m6lkrehi 221 20 , , , cord-335975-m6lkrehi 221 21 p p NN cord-335975-m6lkrehi 221 22 < < XX cord-335975-m6lkrehi 221 23 0.001 0.001 CD cord-335975-m6lkrehi 221 24 ) ) -RRB- cord-335975-m6lkrehi 221 25 . . . cord-335975-m6lkrehi 222 1 Median median JJ cord-335975-m6lkrehi 222 2 plateau plateau NN cord-335975-m6lkrehi 222 3 pressure pressure NN cord-335975-m6lkrehi 222 4 was be VBD cord-335975-m6lkrehi 222 5 25.5 25.5 CD cord-335975-m6lkrehi 222 6 ( ( -LRB- cord-335975-m6lkrehi 222 7 23 23 CD cord-335975-m6lkrehi 222 8 - - SYM cord-335975-m6lkrehi 222 9 29.5 29.5 CD cord-335975-m6lkrehi 222 10 ) ) -RRB- cord-335975-m6lkrehi 222 11 and and CC cord-335975-m6lkrehi 222 12 was be VBD cord-335975-m6lkrehi 222 13 higher high JJR cord-335975-m6lkrehi 222 14 than than IN cord-335975-m6lkrehi 222 15 in in IN cord-335975-m6lkrehi 222 16 mild mild JJ cord-335975-m6lkrehi 222 17 and and CC cord-335975-m6lkrehi 222 18 moderate moderate JJ cord-335975-m6lkrehi 222 19 groups group NNS cord-335975-m6lkrehi 222 20 . . . cord-335975-m6lkrehi 223 1 Median median JJ cord-335975-m6lkrehi 223 2 driving driving NN cord-335975-m6lkrehi 223 3 pressure pressure NN cord-335975-m6lkrehi 223 4 was be VBD cord-335975-m6lkrehi 223 5 13 13 CD cord-335975-m6lkrehi 223 6 ( ( -LRB- cord-335975-m6lkrehi 223 7 10 10 CD cord-335975-m6lkrehi 223 8 - - SYM cord-335975-m6lkrehi 223 9 19 19 CD cord-335975-m6lkrehi 223 10 ) ) -RRB- cord-335975-m6lkrehi 223 11 cm cm . cord-335975-m6lkrehi 224 1 H h NN cord-335975-m6lkrehi 225 1 2 2 LS cord-335975-m6lkrehi 225 2 O o NN cord-335975-m6lkrehi 225 3 with with IN cord-335975-m6lkrehi 225 4 no no DT cord-335975-m6lkrehi 225 5 difference difference NN cord-335975-m6lkrehi 225 6 when when WRB cord-335975-m6lkrehi 225 7 compared compare VBN cord-335975-m6lkrehi 225 8 to to IN cord-335975-m6lkrehi 225 9 other other JJ cord-335975-m6lkrehi 225 10 groups group NNS cord-335975-m6lkrehi 225 11 . . . cord-335975-m6lkrehi 226 1 Neuromuscular neuromuscular JJ cord-335975-m6lkrehi 226 2 blocking block VBG cord-335975-m6lkrehi 226 3 agents agent NNS cord-335975-m6lkrehi 226 4 were be VBD cord-335975-m6lkrehi 226 5 administered administer VBN cord-335975-m6lkrehi 226 6 in in IN cord-335975-m6lkrehi 226 7 28 28 CD cord-335975-m6lkrehi 226 8 ( ( -LRB- cord-335975-m6lkrehi 226 9 51.9 51.9 CD cord-335975-m6lkrehi 226 10 % % NN cord-335975-m6lkrehi 226 11 ) ) -RRB- cord-335975-m6lkrehi 226 12 patients patient NNS cord-335975-m6lkrehi 226 13 , , , cord-335975-m6lkrehi 226 14 inhaled inhale VBD cord-335975-m6lkrehi 226 15 nitric nitric NN cord-335975-m6lkrehi 226 16 oxide oxide NN cord-335975-m6lkrehi 226 17 ( ( -LRB- cord-335975-m6lkrehi 226 18 iNO iNO NNS cord-335975-m6lkrehi 226 19 ) ) -RRB- cord-335975-m6lkrehi 226 20 in in IN cord-335975-m6lkrehi 226 21 7 7 CD cord-335975-m6lkrehi 226 22 ( ( -LRB- cord-335975-m6lkrehi 226 23 13 13 CD cord-335975-m6lkrehi 226 24 % % NN cord-335975-m6lkrehi 226 25 ) ) -RRB- cord-335975-m6lkrehi 226 26 patients patient NNS cord-335975-m6lkrehi 226 27 and and CC cord-335975-m6lkrehi 226 28 only only RB cord-335975-m6lkrehi 226 29 6 6 CD cord-335975-m6lkrehi 226 30 patients patient NNS cord-335975-m6lkrehi 226 31 ( ( -LRB- cord-335975-m6lkrehi 226 32 11.1 11.1 CD cord-335975-m6lkrehi 226 33 % % NN cord-335975-m6lkrehi 226 34 ) ) -RRB- cord-335975-m6lkrehi 226 35 were be VBD cord-335975-m6lkrehi 226 36 on on IN cord-335975-m6lkrehi 226 37 prone prone JJ cord-335975-m6lkrehi 226 38 positioning positioning NN cord-335975-m6lkrehi 226 39 . . . cord-335975-m6lkrehi 227 1 Fourteen fourteen CD cord-335975-m6lkrehi 227 2 ( ( -LRB- cord-335975-m6lkrehi 227 3 18.9 18.9 CD cord-335975-m6lkrehi 227 4 % % NN cord-335975-m6lkrehi 227 5 ) ) -RRB- cord-335975-m6lkrehi 227 6 patients patient NNS cord-335975-m6lkrehi 227 7 were be VBD cord-335975-m6lkrehi 227 8 under under IN cord-335975-m6lkrehi 227 9 extracorporeal extracorporeal JJ cord-335975-m6lkrehi 227 10 membrane membrane NN cord-335975-m6lkrehi 227 11 oxygenation oxygenation NN cord-335975-m6lkrehi 227 12 ( ( -LRB- cord-335975-m6lkrehi 227 13 ECMO ECMO NNP cord-335975-m6lkrehi 227 14 ) ) -RRB- cord-335975-m6lkrehi 227 15 . . . cord-335975-m6lkrehi 228 1 ICU ICU NNP cord-335975-m6lkrehi 228 2 mortality mortality NN cord-335975-m6lkrehi 228 3 was be VBD cord-335975-m6lkrehi 228 4 higher high JJR cord-335975-m6lkrehi 228 5 in in IN cord-335975-m6lkrehi 228 6 severe severe JJ cord-335975-m6lkrehi 228 7 hypoxemic hypoxemic JJ cord-335975-m6lkrehi 228 8 patients patient NNS cord-335975-m6lkrehi 228 9 as as IN cord-335975-m6lkrehi 228 10 compared compare VBN cord-335975-m6lkrehi 228 11 to to IN cord-335975-m6lkrehi 228 12 mild mild JJ cord-335975-m6lkrehi 228 13 and and CC cord-335975-m6lkrehi 228 14 moderate moderate JJ cord-335975-m6lkrehi 228 15 ( ( -LRB- cord-335975-m6lkrehi 228 16 50.7 50.7 CD cord-335975-m6lkrehi 228 17 vs. vs. CC cord-335975-m6lkrehi 228 18 21.3 21.3 CD cord-335975-m6lkrehi 228 19 and and CC cord-335975-m6lkrehi 228 20 28.5 28.5 CD cord-335975-m6lkrehi 228 21 % % NN cord-335975-m6lkrehi 228 22 respectively respectively RB cord-335975-m6lkrehi 228 23 , , , cord-335975-m6lkrehi 228 24 p p NN cord-335975-m6lkrehi 228 25 < < XX cord-335975-m6lkrehi 228 26 0.001 0.001 CD cord-335975-m6lkrehi 228 27 ) ) -RRB- cord-335975-m6lkrehi 228 28 . . . cord-335975-m6lkrehi 229 1 ICU ICU NNP cord-335975-m6lkrehi 229 2 length length NN cord-335975-m6lkrehi 229 3 of of IN cord-335975-m6lkrehi 229 4 stay stay NN cord-335975-m6lkrehi 229 5 in in IN cord-335975-m6lkrehi 229 6 ICU ICU NNP cord-335975-m6lkrehi 229 7 survivors survivor NNS cord-335975-m6lkrehi 229 8 was be VBD cord-335975-m6lkrehi 229 9 not not RB cord-335975-m6lkrehi 229 10 statistically statistically RB cord-335975-m6lkrehi 229 11 different different JJ cord-335975-m6lkrehi 229 12 between between IN cord-335975-m6lkrehi 229 13 groups group NNS cord-335975-m6lkrehi 229 14 . . . cord-335975-m6lkrehi 230 1 Conclusion conclusion NN cord-335975-m6lkrehi 230 2 : : : cord-335975-m6lkrehi 231 1 Severe severe JJ cord-335975-m6lkrehi 231 2 hypoxemia hypoxemia NN cord-335975-m6lkrehi 231 3 , , , cord-335975-m6lkrehi 231 4 independently independently RB cord-335975-m6lkrehi 231 5 from from IN cord-335975-m6lkrehi 231 6 ARDS ARDS NNP cord-335975-m6lkrehi 231 7 , , , cord-335975-m6lkrehi 231 8 worsens worsen VBZ cord-335975-m6lkrehi 231 9 the the DT cord-335975-m6lkrehi 231 10 prognosis prognosis NN cord-335975-m6lkrehi 231 11 of of IN cord-335975-m6lkrehi 231 12 ICU ICU NNP cord-335975-m6lkrehi 231 13 patients patient NNS cord-335975-m6lkrehi 231 14 . . . cord-335975-m6lkrehi 232 1 Even even RB cord-335975-m6lkrehi 232 2 though though IN cord-335975-m6lkrehi 232 3 ARDS ARDS NNP cord-335975-m6lkrehi 232 4 might may MD cord-335975-m6lkrehi 232 5 be be VB cord-335975-m6lkrehi 232 6 underdiagnosed underdiagnosed JJ cord-335975-m6lkrehi 232 7 , , , cord-335975-m6lkrehi 232 8 a a DT cord-335975-m6lkrehi 232 9 protective protective JJ cord-335975-m6lkrehi 232 10 ventilation ventilation NN cord-335975-m6lkrehi 232 11 was be VBD cord-335975-m6lkrehi 232 12 respected respect VBN cord-335975-m6lkrehi 232 13 in in IN cord-335975-m6lkrehi 232 14 severe severe JJ cord-335975-m6lkrehi 232 15 hypoxemic hypoxemic JJ cord-335975-m6lkrehi 232 16 patients patient NNS cord-335975-m6lkrehi 232 17 . . . cord-335975-m6lkrehi 233 1 Introduction introduction NN cord-335975-m6lkrehi 233 2 : : : cord-335975-m6lkrehi 234 1 Major major JJ cord-335975-m6lkrehi 234 2 changes change NNS cord-335975-m6lkrehi 234 3 in in IN cord-335975-m6lkrehi 234 4 septic septic JJ cord-335975-m6lkrehi 234 5 shock shock NN cord-335975-m6lkrehi 234 6 management management NN cord-335975-m6lkrehi 234 7 raise raise VBP cord-335975-m6lkrehi 234 8 the the DT cord-335975-m6lkrehi 234 9 questions question NNS cord-335975-m6lkrehi 234 10 of of IN cord-335975-m6lkrehi 234 11 the the DT cord-335975-m6lkrehi 234 12 relevance relevance NN cord-335975-m6lkrehi 234 13 of of IN cord-335975-m6lkrehi 234 14 the the DT cord-335975-m6lkrehi 234 15 classical classical JJ cord-335975-m6lkrehi 234 16 risk risk NN cord-335975-m6lkrehi 234 17 factors factor NNS cord-335975-m6lkrehi 234 18 of of IN cord-335975-m6lkrehi 234 19 nosocomial nosocomial JJ cord-335975-m6lkrehi 234 20 infections infection NNS cord-335975-m6lkrehi 234 21 in in IN cord-335975-m6lkrehi 234 22 the the DT cord-335975-m6lkrehi 234 23 current current JJ cord-335975-m6lkrehi 234 24 era era NN cord-335975-m6lkrehi 234 25 and and CC cord-335975-m6lkrehi 234 26 the the DT cord-335975-m6lkrehi 234 27 link link NN cord-335975-m6lkrehi 234 28 with with IN cord-335975-m6lkrehi 234 29 the the DT cord-335975-m6lkrehi 234 30 primary primary JJ cord-335975-m6lkrehi 234 31 infectious infectious JJ cord-335975-m6lkrehi 234 32 insult insult NN cord-335975-m6lkrehi 234 33 . . . cord-335975-m6lkrehi 235 1 We -PRON- PRP cord-335975-m6lkrehi 235 2 herein herein RB cord-335975-m6lkrehi 235 3 investigated investigate VBD cord-335975-m6lkrehi 235 4 the the DT cord-335975-m6lkrehi 235 5 risk risk NN cord-335975-m6lkrehi 235 6 factors factor NNS cord-335975-m6lkrehi 235 7 and and CC cord-335975-m6lkrehi 235 8 the the DT cord-335975-m6lkrehi 235 9 outcomes outcome NNS cord-335975-m6lkrehi 235 10 of of IN cord-335975-m6lkrehi 235 11 ICUacquired icuacquire VBN cord-335975-m6lkrehi 235 12 infections infection NNS cord-335975-m6lkrehi 235 13 in in IN cord-335975-m6lkrehi 235 14 a a DT cord-335975-m6lkrehi 235 15 recent recent JJ cord-335975-m6lkrehi 235 16 cohort cohort NN cord-335975-m6lkrehi 235 17 of of IN cord-335975-m6lkrehi 235 18 septic septic JJ cord-335975-m6lkrehi 235 19 shock shock NN cord-335975-m6lkrehi 235 20 patients patient NNS cord-335975-m6lkrehi 235 21 . . . cord-335975-m6lkrehi 236 1 Patients patient NNS cord-335975-m6lkrehi 236 2 and and CC cord-335975-m6lkrehi 236 3 methods method NNS cord-335975-m6lkrehi 236 4 : : : cord-335975-m6lkrehi 236 5 This this DT cord-335975-m6lkrehi 236 6 was be VBD cord-335975-m6lkrehi 236 7 a a DT cord-335975-m6lkrehi 236 8 9-year 9-year CD cord-335975-m6lkrehi 236 9 ( ( -LRB- cord-335975-m6lkrehi 236 10 2008 2008 CD cord-335975-m6lkrehi 236 11 - - SYM cord-335975-m6lkrehi 236 12 2016 2016 CD cord-335975-m6lkrehi 236 13 ) ) -RRB- cord-335975-m6lkrehi 237 1 monocenter monocenter NNP cord-335975-m6lkrehi 237 2 retrospective retrospective NNP cord-335975-m6lkrehi 237 3 study study NN cord-335975-m6lkrehi 237 4 . . . cord-335975-m6lkrehi 238 1 All all DT cord-335975-m6lkrehi 238 2 adult adult NN cord-335975-m6lkrehi 238 3 patients patient NNS cord-335975-m6lkrehi 238 4 diagnosed diagnose VBN cord-335975-m6lkrehi 238 5 for for IN cord-335975-m6lkrehi 238 6 septic septic JJ cord-335975-m6lkrehi 238 7 shock shock NN cord-335975-m6lkrehi 238 8 within within IN cord-335975-m6lkrehi 238 9 the the DT cord-335975-m6lkrehi 238 10 first first JJ cord-335975-m6lkrehi 238 11 48 48 CD cord-335975-m6lkrehi 238 12 h h NN cord-335975-m6lkrehi 238 13 were be VBD cord-335975-m6lkrehi 238 14 included include VBN cord-335975-m6lkrehi 238 15 . . . cord-335975-m6lkrehi 239 1 Septic septic JJ cord-335975-m6lkrehi 239 2 shock shock NN cord-335975-m6lkrehi 239 3 was be VBD cord-335975-m6lkrehi 239 4 defined define VBN cord-335975-m6lkrehi 239 5 as as IN cord-335975-m6lkrehi 239 6 a a DT cord-335975-m6lkrehi 239 7 microbiologically microbiologically NN cord-335975-m6lkrehi 239 8 proven prove VBN cord-335975-m6lkrehi 239 9 or or CC cord-335975-m6lkrehi 239 10 clinically clinically RB cord-335975-m6lkrehi 239 11 suspected suspect VBN cord-335975-m6lkrehi 239 12 infection infection NN cord-335975-m6lkrehi 239 13 , , , cord-335975-m6lkrehi 239 14 associated associate VBN cord-335975-m6lkrehi 239 15 with with IN cord-335975-m6lkrehi 239 16 acute acute JJ cord-335975-m6lkrehi 239 17 circulatory circulatory JJ cord-335975-m6lkrehi 239 18 failure failure NN cord-335975-m6lkrehi 239 19 requiring require VBG cord-335975-m6lkrehi 239 20 vasopressors vasopressor NNS cord-335975-m6lkrehi 239 21 . . . cord-335975-m6lkrehi 240 1 Patients patient NNS cord-335975-m6lkrehi 240 2 who who WP cord-335975-m6lkrehi 240 3 survived survive VBD cord-335975-m6lkrehi 240 4 the the DT cord-335975-m6lkrehi 240 5 first first JJ cord-335975-m6lkrehi 240 6 three three CD cord-335975-m6lkrehi 240 7 days day NNS cord-335975-m6lkrehi 240 8 were be VBD cord-335975-m6lkrehi 240 9 eligible eligible JJ cord-335975-m6lkrehi 240 10 for for IN cord-335975-m6lkrehi 240 11 assessment assessment NN cord-335975-m6lkrehi 240 12 of of IN cord-335975-m6lkrehi 240 13 the the DT cord-335975-m6lkrehi 240 14 risk risk NN cord-335975-m6lkrehi 240 15 of of IN cord-335975-m6lkrehi 240 16 the the DT cord-335975-m6lkrehi 240 17 first first JJ cord-335975-m6lkrehi 240 18 ICU ICU NNP cord-335975-m6lkrehi 240 19 - - HYPH cord-335975-m6lkrehi 240 20 acquired acquire VBN cord-335975-m6lkrehi 240 21 infections infection NNS cord-335975-m6lkrehi 240 22 . . . cord-335975-m6lkrehi 241 1 The the DT cord-335975-m6lkrehi 241 2 diagnosis diagnosis NN cord-335975-m6lkrehi 241 3 of of IN cord-335975-m6lkrehi 241 4 nosocomial nosocomial JJ cord-335975-m6lkrehi 241 5 infections infection NNS cord-335975-m6lkrehi 241 6 were be VBD cord-335975-m6lkrehi 241 7 based base VBN cord-335975-m6lkrehi 241 8 on on IN cord-335975-m6lkrehi 241 9 current current JJ cord-335975-m6lkrehi 241 10 international international JJ cord-335975-m6lkrehi 241 11 guidelines guideline NNS cord-335975-m6lkrehi 241 12 . . . cord-335975-m6lkrehi 242 1 Patients patient NNS cord-335975-m6lkrehi 242 2 were be VBD cord-335975-m6lkrehi 242 3 classified classify VBN cord-335975-m6lkrehi 242 4 according accord VBG cord-335975-m6lkrehi 242 5 to to IN cord-335975-m6lkrehi 242 6 the the DT cord-335975-m6lkrehi 242 7 development development NN cord-335975-m6lkrehi 242 8 of of IN cord-335975-m6lkrehi 242 9 pulmonary pulmonary JJ cord-335975-m6lkrehi 242 10 or or CC cord-335975-m6lkrehi 242 11 non non JJ cord-335975-m6lkrehi 242 12 - - JJ cord-335975-m6lkrehi 242 13 pulmonary pulmonary JJ cord-335975-m6lkrehi 242 14 ICU ICU NNP cord-335975-m6lkrehi 242 15 - - HYPH cord-335975-m6lkrehi 242 16 acquired acquire VBN cord-335975-m6lkrehi 242 17 infections infection NNS cord-335975-m6lkrehi 242 18 . . . cord-335975-m6lkrehi 243 1 The the DT cord-335975-m6lkrehi 243 2 determinants determinant NNS cord-335975-m6lkrehi 243 3 of of IN cord-335975-m6lkrehi 243 4 ICU ICU NNP cord-335975-m6lkrehi 243 5 - - HYPH cord-335975-m6lkrehi 243 6 acquired acquire VBN cord-335975-m6lkrehi 243 7 infections infection NNS cord-335975-m6lkrehi 243 8 were be VBD cord-335975-m6lkrehi 243 9 addressed address VBN cord-335975-m6lkrehi 243 10 in in IN cord-335975-m6lkrehi 243 11 a a DT cord-335975-m6lkrehi 243 12 multivariate multivariate JJ cord-335975-m6lkrehi 243 13 logistic logistic JJ cord-335975-m6lkrehi 243 14 regression regression NN cord-335975-m6lkrehi 243 15 analysis analysis NN cord-335975-m6lkrehi 243 16 . . . cord-335975-m6lkrehi 244 1 Results result NNS cord-335975-m6lkrehi 244 2 : : : cord-335975-m6lkrehi 245 1 938 938 CD cord-335975-m6lkrehi 245 2 patients patient NNS cord-335975-m6lkrehi 245 3 were be VBD cord-335975-m6lkrehi 245 4 admitted admit VBN cord-335975-m6lkrehi 245 5 for for IN cord-335975-m6lkrehi 245 6 septic septic JJ cord-335975-m6lkrehi 245 7 shock shock NN cord-335975-m6lkrehi 245 8 . . . cord-335975-m6lkrehi 246 1 788 788 CD cord-335975-m6lkrehi 246 2 patients patient NNS cord-335975-m6lkrehi 246 3 remained remain VBD cord-335975-m6lkrehi 246 4 alive alive JJ cord-335975-m6lkrehi 246 5 in in IN cord-335975-m6lkrehi 246 6 the the DT cord-335975-m6lkrehi 246 7 ICU ICU NNP cord-335975-m6lkrehi 246 8 after after IN cord-335975-m6lkrehi 246 9 the the DT cord-335975-m6lkrehi 246 10 first first JJ cord-335975-m6lkrehi 246 11 three three CD cord-335975-m6lkrehi 246 12 days day NNS cord-335975-m6lkrehi 246 13 and and CC cord-335975-m6lkrehi 246 14 could could MD cord-335975-m6lkrehi 246 15 then then RB cord-335975-m6lkrehi 246 16 be be VB cord-335975-m6lkrehi 246 17 evaluated evaluate VBN cord-335975-m6lkrehi 246 18 for for IN cord-335975-m6lkrehi 246 19 the the DT cord-335975-m6lkrehi 246 20 risk risk NN cord-335975-m6lkrehi 246 21 of of IN cord-335975-m6lkrehi 246 22 ICU ICU NNP cord-335975-m6lkrehi 246 23 - - HYPH cord-335975-m6lkrehi 246 24 acquired acquire VBN cord-335975-m6lkrehi 246 25 infections infection NNS cord-335975-m6lkrehi 246 26 . . . cord-335975-m6lkrehi 247 1 Hence hence RB cord-335975-m6lkrehi 247 2 , , , cord-335975-m6lkrehi 247 3 554 554 CD cord-335975-m6lkrehi 247 4 patients patient NNS cord-335975-m6lkrehi 247 5 remained remain VBD cord-335975-m6lkrehi 247 6 free free JJ cord-335975-m6lkrehi 247 7 of of IN cord-335975-m6lkrehi 247 8 secondary secondary JJ cord-335975-m6lkrehi 247 9 infections infection NNS cord-335975-m6lkrehi 247 10 , , , cord-335975-m6lkrehi 247 11 138 138 CD cord-335975-m6lkrehi 247 12 patients patient NNS cord-335975-m6lkrehi 247 13 first first RB cord-335975-m6lkrehi 247 14 developed develop VBD cord-335975-m6lkrehi 247 15 an an DT cord-335975-m6lkrehi 247 16 episode episode NN cord-335975-m6lkrehi 247 17 of of IN cord-335975-m6lkrehi 247 18 nosocomial nosocomial JJ cord-335975-m6lkrehi 247 19 pneumonia pneumonia NN cord-335975-m6lkrehi 247 20 and and CC cord-335975-m6lkrehi 247 21 96 96 CD cord-335975-m6lkrehi 247 22 patients patient NNS cord-335975-m6lkrehi 247 23 first first RB cord-335975-m6lkrehi 247 24 developed develop VBD cord-335975-m6lkrehi 247 25 an an DT cord-335975-m6lkrehi 247 26 episode episode NN cord-335975-m6lkrehi 247 27 of of IN cord-335975-m6lkrehi 247 28 non non JJ cord-335975-m6lkrehi 247 29 - - JJ cord-335975-m6lkrehi 247 30 pulmonary pulmonary JJ cord-335975-m6lkrehi 247 31 infection infection NN cord-335975-m6lkrehi 247 32 . . . cord-335975-m6lkrehi 248 1 The the DT cord-335975-m6lkrehi 248 2 mortality mortality NN cord-335975-m6lkrehi 248 3 rates rate NNS cord-335975-m6lkrehi 248 4 of of IN cord-335975-m6lkrehi 248 5 patients patient NNS cord-335975-m6lkrehi 248 6 with with IN cord-335975-m6lkrehi 248 7 ICU ICU NNP cord-335975-m6lkrehi 248 8 - - HYPH cord-335975-m6lkrehi 248 9 acquired acquire VBN cord-335975-m6lkrehi 248 10 pneumonia pneumonia NN cord-335975-m6lkrehi 248 11 , , , cord-335975-m6lkrehi 248 12 non non JJ cord-335975-m6lkrehi 248 13 - - JJ cord-335975-m6lkrehi 248 14 pulmonary pulmonary JJ cord-335975-m6lkrehi 248 15 ICU ICU NNP cord-335975-m6lkrehi 248 16 - - HYPH cord-335975-m6lkrehi 248 17 acquired acquire VBN cord-335975-m6lkrehi 248 18 infections infection NNS cord-335975-m6lkrehi 248 19 and and CC cord-335975-m6lkrehi 248 20 without without IN cord-335975-m6lkrehi 248 21 secondary secondary JJ cord-335975-m6lkrehi 248 22 infections infection NNS cord-335975-m6lkrehi 248 23 were be VBD cord-335975-m6lkrehi 248 24 49 49 CD cord-335975-m6lkrehi 248 25 , , , cord-335975-m6lkrehi 248 26 49 49 CD cord-335975-m6lkrehi 248 27 and and CC cord-335975-m6lkrehi 248 28 14 14 CD cord-335975-m6lkrehi 248 29 % % NN cord-335975-m6lkrehi 248 30 , , , cord-335975-m6lkrehi 248 31 respectively respectively RB cord-335975-m6lkrehi 248 32 ( ( -LRB- cord-335975-m6lkrehi 248 33 p p NN cord-335975-m6lkrehi 248 34 = = SYM cord-335975-m6lkrehi 248 35 0.0001 0.0001 CD cord-335975-m6lkrehi 248 36 ) ) -RRB- cord-335975-m6lkrehi 248 37 . . . cord-335975-m6lkrehi 249 1 In in IN cord-335975-m6lkrehi 249 2 multivariate multivariate JJ cord-335975-m6lkrehi 249 3 analysis analysis NN cord-335975-m6lkrehi 249 4 , , , cord-335975-m6lkrehi 249 5 the the DT cord-335975-m6lkrehi 249 6 development development NN cord-335975-m6lkrehi 249 7 of of IN cord-335975-m6lkrehi 249 8 ICU ICU NNP cord-335975-m6lkrehi 249 9 - - HYPH cord-335975-m6lkrehi 249 10 acquired acquire VBN cord-335975-m6lkrehi 249 11 pneumonia pneumonia NN cord-335975-m6lkrehi 249 12 was be VBD cord-335975-m6lkrehi 249 13 independently independently RB cord-335975-m6lkrehi 249 14 associated associate VBN cord-335975-m6lkrehi 249 15 with with IN cord-335975-m6lkrehi 249 16 male male JJ cord-335975-m6lkrehi 249 17 gender gender NN cord-335975-m6lkrehi 249 18 ( ( -LRB- cord-335975-m6lkrehi 249 19 OR or CC cord-335975-m6lkrehi 249 20 2.23 2.23 CD cord-335975-m6lkrehi 249 21 , , , cord-335975-m6lkrehi 249 22 CI CI NNP cord-335975-m6lkrehi 249 23 95 95 CD cord-335975-m6lkrehi 249 24 % % NN cord-335975-m6lkrehi 249 25 [ [ -LRB- cord-335975-m6lkrehi 249 26 1.28 1.28 CD cord-335975-m6lkrehi 249 27 - - HYPH cord-335975-m6lkrehi 249 28 3.48 3.48 CD cord-335975-m6lkrehi 249 29 ] ] -RRB- cord-335975-m6lkrehi 249 30 , , , cord-335975-m6lkrehi 249 31 p p NN cord-335975-m6lkrehi 249 32 = = SYM cord-335975-m6lkrehi 249 33 0.003 0.003 CD cord-335975-m6lkrehi 249 34 ) ) -RRB- cord-335975-m6lkrehi 249 35 , , , cord-335975-m6lkrehi 249 36 renal renal JJ cord-335975-m6lkrehi 249 37 replacement replacement NN cord-335975-m6lkrehi 249 38 therapy therapy NN cord-335975-m6lkrehi 249 39 ( ( -LRB- cord-335975-m6lkrehi 249 40 OR or CC cord-335975-m6lkrehi 249 41 2.15 2.15 CD cord-335975-m6lkrehi 249 42 , , , cord-335975-m6lkrehi 249 43 CI CI NNP cord-335975-m6lkrehi 249 44 95 95 CD cord-335975-m6lkrehi 249 45 % % NN cord-335975-m6lkrehi 249 46 [ [ -LRB- cord-335975-m6lkrehi 249 47 1.35 1.35 CD cord-335975-m6lkrehi 249 48 - - SYM cord-335975-m6lkrehi 249 49 3.42 3.42 CD cord-335975-m6lkrehi 249 50 ] ] -RRB- cord-335975-m6lkrehi 249 51 , , , cord-335975-m6lkrehi 249 52 p p NN cord-335975-m6lkrehi 249 53 = = SYM cord-335975-m6lkrehi 249 54 0.001 0.001 CD cord-335975-m6lkrehi 249 55 ) ) -RRB- cord-335975-m6lkrehi 249 56 , , , cord-335975-m6lkrehi 249 57 platelet platelet NN cord-335975-m6lkrehi 249 58 transfusion transfusion NN cord-335975-m6lkrehi 249 59 ( ( -LRB- cord-335975-m6lkrehi 249 60 OR or CC cord-335975-m6lkrehi 249 61 2.38 2.38 CD cord-335975-m6lkrehi 249 62 , , , cord-335975-m6lkrehi 249 63 CI CI NNP cord-335975-m6lkrehi 249 64 95 95 CD cord-335975-m6lkrehi 249 65 % % NN cord-335975-m6lkrehi 249 66 [ [ -LRB- cord-335975-m6lkrehi 249 67 1.4 1.4 CD cord-335975-m6lkrehi 249 68 - - SYM cord-335975-m6lkrehi 249 69 4 4 CD cord-335975-m6lkrehi 249 70 .04 .04 CD cord-335975-m6lkrehi 249 71 ] ] -RRB- cord-335975-m6lkrehi 249 72 , , , cord-335975-m6lkrehi 249 73 p p NN cord-335975-m6lkrehi 249 74 = = SYM cord-335975-m6lkrehi 249 75 0.001 0.001 CD cord-335975-m6lkrehi 249 76 ) ) -RRB- cord-335975-m6lkrehi 249 77 and and CC cord-335975-m6lkrehi 249 78 a a DT cord-335975-m6lkrehi 249 79 primary primary JJ cord-335975-m6lkrehi 249 80 pulmonary pulmonary JJ cord-335975-m6lkrehi 249 81 infection infection NN cord-335975-m6lkrehi 249 82 ( ( -LRB- cord-335975-m6lkrehi 249 83 OR OR NNP cord-335975-m6lkrehi 249 84 8.06 8.06 CD cord-335975-m6lkrehi 249 85 , , , cord-335975-m6lkrehi 249 86 CI CI NNP cord-335975-m6lkrehi 249 87 95 95 CD cord-335975-m6lkrehi 249 88 % % NN cord-335975-m6lkrehi 249 89 [ [ -LRB- cord-335975-m6lkrehi 249 90 2.69 2.69 CD cord-335975-m6lkrehi 249 91 - - SYM cord-335975-m6lkrehi 249 92 24 24 CD cord-335975-m6lkrehi 249 93 .12 .12 CD cord-335975-m6lkrehi 249 94 ] ] -RRB- cord-335975-m6lkrehi 249 95 , , , cord-335975-m6lkrehi 249 96 p p NN cord-335975-m6lkrehi 249 97 < < XX cord-335975-m6lkrehi 249 98 0.001 0.001 CD cord-335975-m6lkrehi 249 99 ) ) -RRB- cord-335975-m6lkrehi 249 100 . . . cord-335975-m6lkrehi 250 1 The the DT cord-335975-m6lkrehi 250 2 development development NN cord-335975-m6lkrehi 250 3 of of IN cord-335975-m6lkrehi 250 4 non non JJ cord-335975-m6lkrehi 250 5 - - JJ cord-335975-m6lkrehi 250 6 pulmonary pulmonary JJ cord-335975-m6lkrehi 250 7 infections infection NNS cord-335975-m6lkrehi 250 8 was be VBD cord-335975-m6lkrehi 250 9 independently independently RB cord-335975-m6lkrehi 250 10 associated associate VBN cord-335975-m6lkrehi 250 11 with with IN cord-335975-m6lkrehi 250 12 renal renal JJ cord-335975-m6lkrehi 250 13 replacement replacement NN cord-335975-m6lkrehi 250 14 therapy therapy NN cord-335975-m6lkrehi 250 15 ( ( -LRB- cord-335975-m6lkrehi 250 16 OR or CC cord-335975-m6lkrehi 250 17 4.6 4.6 CD cord-335975-m6lkrehi 250 18 , , , cord-335975-m6lkrehi 250 19 CI CI NNP cord-335975-m6lkrehi 250 20 95 95 CD cord-335975-m6lkrehi 250 21 % % NN cord-335975-m6lkrehi 250 22 [ [ -LRB- cord-335975-m6lkrehi 250 23 2.7 2.7 CD cord-335975-m6lkrehi 250 24 - - SYM cord-335975-m6lkrehi 250 25 7 7 CD cord-335975-m6lkrehi 250 26 .85 .85 CD cord-335975-m6lkrehi 250 27 ] ] -RRB- cord-335975-m6lkrehi 250 28 , , , cord-335975-m6lkrehi 250 29 p p NN cord-335975-m6lkrehi 250 30 < < XX cord-335975-m6lkrehi 250 31 0.001 0.001 CD cord-335975-m6lkrehi 250 32 ) ) -RRB- cord-335975-m6lkrehi 250 33 , , , cord-335975-m6lkrehi 250 34 fresh fresh JJ cord-335975-m6lkrehi 250 35 frozen frozen JJ cord-335975-m6lkrehi 250 36 plasma plasma NN cord-335975-m6lkrehi 250 37 transfusion transfusion NN cord-335975-m6lkrehi 250 38 ( ( -LRB- cord-335975-m6lkrehi 250 39 OR or CC cord-335975-m6lkrehi 250 40 2.49 2.49 CD cord-335975-m6lkrehi 250 41 , , , cord-335975-m6lkrehi 250 42 CI CI NNP cord-335975-m6lkrehi 250 43 95 95 CD cord-335975-m6lkrehi 250 44 % % NN cord-335975-m6lkrehi 250 45 [ [ -LRB- cord-335975-m6lkrehi 250 46 1.42 1.42 CD cord-335975-m6lkrehi 250 47 - - SYM cord-335975-m6lkrehi 250 48 4.37 4.37 CD cord-335975-m6lkrehi 250 49 ] ] -RRB- cord-335975-m6lkrehi 250 50 , , , cord-335975-m6lkrehi 250 51 p p NN cord-335975-m6lkrehi 250 52 = = SYM cord-335975-m6lkrehi 250 53 0.001 0.001 CD cord-335975-m6lkrehi 250 54 ) ) -RRB- cord-335975-m6lkrehi 250 55 , , , cord-335975-m6lkrehi 250 56 healthcare healthcare NN cord-335975-m6lkrehi 250 57 - - HYPH cord-335975-m6lkrehi 250 58 associated associate VBN cord-335975-m6lkrehi 250 59 septic septic JJ cord-335975-m6lkrehi 250 60 shock shock NN cord-335975-m6lkrehi 250 61 ( ( -LRB- cord-335975-m6lkrehi 250 62 OR or CC cord-335975-m6lkrehi 250 63 1.8 1.8 CD cord-335975-m6lkrehi 250 64 , , , cord-335975-m6lkrehi 250 65 CI CI NNP cord-335975-m6lkrehi 250 66 95 95 CD cord-335975-m6lkrehi 250 67 % % NN cord-335975-m6lkrehi 250 68 [ [ -LRB- cord-335975-m6lkrehi 250 69 1.1 1.1 CD cord-335975-m6lkrehi 250 70 - - HYPH cord-335975-m6lkrehi 250 71 2.91 2.91 CD cord-335975-m6lkrehi 250 72 ] ] -RRB- cord-335975-m6lkrehi 250 73 , , , cord-335975-m6lkrehi 250 74 p p NN cord-335975-m6lkrehi 250 75 = = SYM cord-335975-m6lkrehi 250 76 0.01 0.01 CD cord-335975-m6lkrehi 250 77 ) ) -RRB- cord-335975-m6lkrehi 250 78 . . . cord-335975-m6lkrehi 251 1 Conclusion conclusion NN cord-335975-m6lkrehi 251 2 : : : cord-335975-m6lkrehi 252 1 ICU ICU NNP cord-335975-m6lkrehi 252 2 - - HYPH cord-335975-m6lkrehi 252 3 acquired acquire VBN cord-335975-m6lkrehi 252 4 pneumonia pneumonia NN cord-335975-m6lkrehi 252 5 occurs occur VBZ cord-335975-m6lkrehi 252 6 preferentially preferentially RB cord-335975-m6lkrehi 252 7 in in IN cord-335975-m6lkrehi 252 8 patients patient NNS cord-335975-m6lkrehi 252 9 with with IN cord-335975-m6lkrehi 252 10 septic septic JJ cord-335975-m6lkrehi 252 11 shock shock NN cord-335975-m6lkrehi 252 12 of of IN cord-335975-m6lkrehi 252 13 pulmonary pulmonary JJ cord-335975-m6lkrehi 252 14 origin origin NN cord-335975-m6lkrehi 252 15 . . . cord-335975-m6lkrehi 253 1 In in IN cord-335975-m6lkrehi 253 2 addition addition NN cord-335975-m6lkrehi 253 3 , , , cord-335975-m6lkrehi 253 4 we -PRON- PRP cord-335975-m6lkrehi 253 5 identified identify VBD cord-335975-m6lkrehi 253 6 the the DT cord-335975-m6lkrehi 253 7 transfusion transfusion NN cord-335975-m6lkrehi 253 8 of of IN cord-335975-m6lkrehi 253 9 blood blood NN cord-335975-m6lkrehi 253 10 products product NNS cord-335975-m6lkrehi 253 11 as as IN cord-335975-m6lkrehi 253 12 a a DT cord-335975-m6lkrehi 253 13 risk risk NN cord-335975-m6lkrehi 253 14 factor factor NN cord-335975-m6lkrehi 253 15 for for IN cord-335975-m6lkrehi 253 16 pulmonary pulmonary JJ cord-335975-m6lkrehi 253 17 and and CC cord-335975-m6lkrehi 253 18 nonpulmonary nonpulmonary JJ cord-335975-m6lkrehi 253 19 nosocomial nosocomial JJ cord-335975-m6lkrehi 253 20 infections infection NNS cord-335975-m6lkrehi 253 21 . . . cord-335975-m6lkrehi 254 1 Introduction introduction NN cord-335975-m6lkrehi 254 2 : : : cord-335975-m6lkrehi 255 1 Human human JJ cord-335975-m6lkrehi 255 2 serum serum NN cord-335975-m6lkrehi 255 3 albumin albumin NN cord-335975-m6lkrehi 255 4 is be VBZ cord-335975-m6lkrehi 255 5 used use VBN cord-335975-m6lkrehi 255 6 for for IN cord-335975-m6lkrehi 255 7 the the DT cord-335975-m6lkrehi 255 8 restoration restoration NN cord-335975-m6lkrehi 255 9 of of IN cord-335975-m6lkrehi 255 10 blood blood NN cord-335975-m6lkrehi 255 11 volume volume NN cord-335975-m6lkrehi 255 12 , , , cord-335975-m6lkrehi 255 13 emergency emergency NN cord-335975-m6lkrehi 255 14 treatment treatment NN cord-335975-m6lkrehi 255 15 of of IN cord-335975-m6lkrehi 255 16 septic septic JJ cord-335975-m6lkrehi 255 17 shock shock NN cord-335975-m6lkrehi 255 18 patients patient NNS cord-335975-m6lkrehi 255 19 . . . cord-335975-m6lkrehi 256 1 Several several JJ cord-335975-m6lkrehi 256 2 experimental experimental JJ cord-335975-m6lkrehi 256 3 studies study NNS cord-335975-m6lkrehi 256 4 suggested suggest VBD cord-335975-m6lkrehi 256 5 that that IN cord-335975-m6lkrehi 256 6 albumin albumin NN cord-335975-m6lkrehi 256 7 could could MD cord-335975-m6lkrehi 256 8 have have VB cord-335975-m6lkrehi 256 9 additional additional JJ cord-335975-m6lkrehi 256 10 protective protective JJ cord-335975-m6lkrehi 256 11 effects effect NNS cord-335975-m6lkrehi 256 12 on on IN cord-335975-m6lkrehi 256 13 the the DT cord-335975-m6lkrehi 256 14 vascular vascular JJ cord-335975-m6lkrehi 256 15 wall wall NN cord-335975-m6lkrehi 256 16 and and CC cord-335975-m6lkrehi 256 17 more more JJR cord-335975-m6lkrehi 256 18 specifically specifically RB cord-335975-m6lkrehi 256 19 on on IN cord-335975-m6lkrehi 256 20 endothelial endothelial JJ cord-335975-m6lkrehi 256 21 functions function NNS cord-335975-m6lkrehi 256 22 . . . cord-335975-m6lkrehi 257 1 However however RB cord-335975-m6lkrehi 257 2 , , , cord-335975-m6lkrehi 257 3 the the DT cord-335975-m6lkrehi 257 4 in in IN cord-335975-m6lkrehi 257 5 vivo vivo NN cord-335975-m6lkrehi 257 6 effect effect NN cord-335975-m6lkrehi 257 7 of of IN cord-335975-m6lkrehi 257 8 albumin albumin NN cord-335975-m6lkrehi 257 9 in in IN cord-335975-m6lkrehi 257 10 human human JJ cord-335975-m6lkrehi 257 11 endothelium endothelium NN cord-335975-m6lkrehi 257 12 remains remain VBZ cord-335975-m6lkrehi 257 13 unknown unknown JJ cord-335975-m6lkrehi 257 14 . . . cord-335975-m6lkrehi 258 1 The the DT cord-335975-m6lkrehi 258 2 aim aim NN cord-335975-m6lkrehi 258 3 of of IN cord-335975-m6lkrehi 258 4 this this DT cord-335975-m6lkrehi 258 5 study study NN cord-335975-m6lkrehi 258 6 is be VBZ cord-335975-m6lkrehi 258 7 to to TO cord-335975-m6lkrehi 258 8 assess assess VB cord-335975-m6lkrehi 258 9 the the DT cord-335975-m6lkrehi 258 10 effect effect NN cord-335975-m6lkrehi 258 11 of of IN cord-335975-m6lkrehi 258 12 albumin albumin NN cord-335975-m6lkrehi 258 13 or or CC cord-335975-m6lkrehi 258 14 saline saline NN cord-335975-m6lkrehi 258 15 infusion infusion NN cord-335975-m6lkrehi 258 16 on on IN cord-335975-m6lkrehi 258 17 skin skin NN cord-335975-m6lkrehi 258 18 endothelial endothelial JJ cord-335975-m6lkrehi 258 19 function function NN cord-335975-m6lkrehi 258 20 in in IN cord-335975-m6lkrehi 258 21 septic septic JJ cord-335975-m6lkrehi 258 22 shock shock NN cord-335975-m6lkrehi 258 23 patients patient NNS cord-335975-m6lkrehi 258 24 requiring require VBG cord-335975-m6lkrehi 258 25 volume volume NN cord-335975-m6lkrehi 258 26 expansion expansion NN cord-335975-m6lkrehi 258 27 . . . cord-335975-m6lkrehi 259 1 We -PRON- PRP cord-335975-m6lkrehi 259 2 performed perform VBD cord-335975-m6lkrehi 259 3 a a DT cord-335975-m6lkrehi 259 4 prospective prospective JJ cord-335975-m6lkrehi 259 5 randomized randomize VBN cord-335975-m6lkrehi 259 6 monocentric monocentric JJ cord-335975-m6lkrehi 259 7 study study NN cord-335975-m6lkrehi 259 8 in in IN cord-335975-m6lkrehi 259 9 an an DT cord-335975-m6lkrehi 259 10 18-bed 18-bed CD cord-335975-m6lkrehi 259 11 medical medical JJ cord-335975-m6lkrehi 259 12 intensive intensive JJ cord-335975-m6lkrehi 259 13 care care NN cord-335975-m6lkrehi 259 14 unit unit NN cord-335975-m6lkrehi 259 15 . . . cord-335975-m6lkrehi 260 1 All all DT cord-335975-m6lkrehi 260 2 patients patient NNS cord-335975-m6lkrehi 260 3 with with IN cord-335975-m6lkrehi 260 4 septic septic JJ cord-335975-m6lkrehi 260 5 shock shock NN cord-335975-m6lkrehi 260 6 who who WP cord-335975-m6lkrehi 260 7 required require VBD cord-335975-m6lkrehi 260 8 fluid fluid JJ cord-335975-m6lkrehi 260 9 administration administration NN cord-335975-m6lkrehi 260 10 were be VBD cord-335975-m6lkrehi 260 11 included include VBN cord-335975-m6lkrehi 260 12 between between IN cord-335975-m6lkrehi 260 13 H6 H6 NNP cord-335975-m6lkrehi 260 14 and and CC cord-335975-m6lkrehi 260 15 H24 H24 NNP cord-335975-m6lkrehi 260 16 after after IN cord-335975-m6lkrehi 260 17 vasopressor vasopressor NN cord-335975-m6lkrehi 260 18 starting starting NN cord-335975-m6lkrehi 260 19 . . . cord-335975-m6lkrehi 261 1 Patients patient NNS cord-335975-m6lkrehi 261 2 were be VBD cord-335975-m6lkrehi 261 3 randomized randomize VBN cord-335975-m6lkrehi 261 4 to to TO cord-335975-m6lkrehi 261 5 receive receive VB cord-335975-m6lkrehi 261 6 either either CC cord-335975-m6lkrehi 261 7 500 500 CD cord-335975-m6lkrehi 261 8 ml ml NNS cord-335975-m6lkrehi 261 9 of of IN cord-335975-m6lkrehi 261 10 saline saline NN cord-335975-m6lkrehi 261 11 solution solution NN cord-335975-m6lkrehi 261 12 0.9 0.9 CD cord-335975-m6lkrehi 261 13 % % NN cord-335975-m6lkrehi 261 14 or or CC cord-335975-m6lkrehi 261 15 100 100 CD cord-335975-m6lkrehi 261 16 ml ml NNS cord-335975-m6lkrehi 261 17 of of IN cord-335975-m6lkrehi 261 18 albumin albumin NN cord-335975-m6lkrehi 261 19 20 20 CD cord-335975-m6lkrehi 261 20 % % NN cord-335975-m6lkrehi 261 21 . . . cord-335975-m6lkrehi 262 1 Norepinephrine norepinephrine NN cord-335975-m6lkrehi 262 2 dose dose NN cord-335975-m6lkrehi 262 3 was be VBD cord-335975-m6lkrehi 262 4 not not RB cord-335975-m6lkrehi 262 5 modified modify VBN cord-335975-m6lkrehi 262 6 1 1 CD cord-335975-m6lkrehi 262 7 h h NN cord-335975-m6lkrehi 262 8 before before IN cord-335975-m6lkrehi 262 9 and and CC cord-335975-m6lkrehi 262 10 during during IN cord-335975-m6lkrehi 262 11 the the DT cord-335975-m6lkrehi 262 12 procedure procedure NN cord-335975-m6lkrehi 262 13 . . . cord-335975-m6lkrehi 263 1 Endothelium endothelium NN cord-335975-m6lkrehi 263 2 - - HYPH cord-335975-m6lkrehi 263 3 dependant dependant JJ cord-335975-m6lkrehi 263 4 vasodilatation vasodilatation NN cord-335975-m6lkrehi 263 5 in in IN cord-335975-m6lkrehi 263 6 the the DT cord-335975-m6lkrehi 263 7 skin skin NN cord-335975-m6lkrehi 263 8 circulation circulation NN cord-335975-m6lkrehi 263 9 was be VBD cord-335975-m6lkrehi 263 10 assessed assess VBN cord-335975-m6lkrehi 263 11 by by IN cord-335975-m6lkrehi 263 12 iontophoresis iontophoresis NN cord-335975-m6lkrehi 263 13 of of IN cord-335975-m6lkrehi 263 14 acetylcholine acetylcholine NN cord-335975-m6lkrehi 263 15 before before IN cord-335975-m6lkrehi 263 16 and and CC cord-335975-m6lkrehi 263 17 after after IN cord-335975-m6lkrehi 263 18 fluid fluid JJ cord-335975-m6lkrehi 263 19 administration administration NN cord-335975-m6lkrehi 263 20 . . . cord-335975-m6lkrehi 264 1 The the DT cord-335975-m6lkrehi 264 2 improvement improvement NN cord-335975-m6lkrehi 264 3 of of IN cord-335975-m6lkrehi 264 4 skin skin NN cord-335975-m6lkrehi 264 5 blood blood NN cord-335975-m6lkrehi 264 6 flow flow NN cord-335975-m6lkrehi 264 7 in in IN cord-335975-m6lkrehi 264 8 response response NN cord-335975-m6lkrehi 264 9 to to IN cord-335975-m6lkrehi 264 10 acetylcholine acetylcholine NN cord-335975-m6lkrehi 264 11 after after IN cord-335975-m6lkrehi 264 12 fluid fluid JJ cord-335975-m6lkrehi 264 13 administration administration NN cord-335975-m6lkrehi 264 14 was be VBD cord-335975-m6lkrehi 264 15 compared compare VBN cord-335975-m6lkrehi 264 16 between between IN cord-335975-m6lkrehi 264 17 groups group NNS cord-335975-m6lkrehi 264 18 . . . cord-335975-m6lkrehi 265 1 For for IN cord-335975-m6lkrehi 265 2 each each DT cord-335975-m6lkrehi 265 3 patient patient NN cord-335975-m6lkrehi 265 4 , , , cord-335975-m6lkrehi 265 5 age age NN cord-335975-m6lkrehi 265 6 , , , cord-335975-m6lkrehi 265 7 sex sex NN cord-335975-m6lkrehi 265 8 , , , cord-335975-m6lkrehi 265 9 SAPS SAPS NNP cord-335975-m6lkrehi 265 10 II II NNP cord-335975-m6lkrehi 265 11 , , , cord-335975-m6lkrehi 265 12 site site NN cord-335975-m6lkrehi 265 13 of of IN cord-335975-m6lkrehi 265 14 infection infection NN cord-335975-m6lkrehi 265 15 , , , cord-335975-m6lkrehi 265 16 global global JJ cord-335975-m6lkrehi 265 17 hemodynamic hemodynamic JJ cord-335975-m6lkrehi 265 18 parameters parameter NNS cord-335975-m6lkrehi 265 19 and and CC cord-335975-m6lkrehi 265 20 clinical clinical JJ cord-335975-m6lkrehi 265 21 microcirculatory microcirculatory JJ cord-335975-m6lkrehi 265 22 parameters parameter NNS cord-335975-m6lkrehi 265 23 were be VBD cord-335975-m6lkrehi 265 24 recorded record VBN cord-335975-m6lkrehi 265 25 . . . cord-335975-m6lkrehi 266 1 Results result NNS cord-335975-m6lkrehi 266 2 are be VBP cord-335975-m6lkrehi 266 3 expressed express VBN cord-335975-m6lkrehi 266 4 as as IN cord-335975-m6lkrehi 266 5 mean mean JJ cord-335975-m6lkrehi 266 6 ± ± NNP cord-335975-m6lkrehi 266 7 SD SD NNP cord-335975-m6lkrehi 266 8 . . . cord-335975-m6lkrehi 267 1 Qualitative qualitative JJ cord-335975-m6lkrehi 267 2 data datum NNS cord-335975-m6lkrehi 267 3 were be VBD cord-335975-m6lkrehi 267 4 compared compare VBN cord-335975-m6lkrehi 267 5 using use VBG cord-335975-m6lkrehi 267 6 Chi-2 Chi-2 NNP cord-335975-m6lkrehi 267 7 or or CC cord-335975-m6lkrehi 267 8 Fisher Fisher NNP cord-335975-m6lkrehi 267 9 's 's POS cord-335975-m6lkrehi 267 10 exact exact JJ cord-335975-m6lkrehi 267 11 test test NN cord-335975-m6lkrehi 267 12 while while IN cord-335975-m6lkrehi 267 13 quantitative quantitative JJ cord-335975-m6lkrehi 267 14 data data NN cord-335975-m6lkrehi 267 15 comparisons comparison NNS cord-335975-m6lkrehi 267 16 used use VBD cord-335975-m6lkrehi 267 17 Student Student NNP cord-335975-m6lkrehi 267 18 t t NN cord-335975-m6lkrehi 267 19 Test Test NNP cord-335975-m6lkrehi 267 20 or or CC cord-335975-m6lkrehi 267 21 Mann Mann NNP cord-335975-m6lkrehi 267 22 - - HYPH cord-335975-m6lkrehi 267 23 Whitney Whitney NNP cord-335975-m6lkrehi 267 24 as as IN cord-335975-m6lkrehi 267 25 appropriate appropriate JJ cord-335975-m6lkrehi 267 26 . . . cord-335975-m6lkrehi 268 1 Results result NNS cord-335975-m6lkrehi 268 2 : : : cord-335975-m6lkrehi 269 1 Twenty twenty CD cord-335975-m6lkrehi 269 2 - - HYPH cord-335975-m6lkrehi 269 3 two two CD cord-335975-m6lkrehi 269 4 patients patient NNS cord-335975-m6lkrehi 269 5 were be VBD cord-335975-m6lkrehi 269 6 included include VBN cord-335975-m6lkrehi 269 7 ( ( -LRB- cord-335975-m6lkrehi 269 8 12 12 CD cord-335975-m6lkrehi 269 9 women woman NNS cord-335975-m6lkrehi 269 10 , , , cord-335975-m6lkrehi 269 11 age age NN cord-335975-m6lkrehi 269 12 : : : cord-335975-m6lkrehi 269 13 79 79 CD cord-335975-m6lkrehi 269 14 ± ± CD cord-335975-m6lkrehi 269 15 17 17 CD cord-335975-m6lkrehi 269 16 , , , cord-335975-m6lkrehi 269 17 SAPS SAPS NNP cord-335975-m6lkrehi 269 18 II II NNP cord-335975-m6lkrehi 269 19 : : : cord-335975-m6lkrehi 269 20 42 42 CD cord-335975-m6lkrehi 269 21 ± ± CD cord-335975-m6lkrehi 269 22 12 12 CD cord-335975-m6lkrehi 269 23 ) ) -RRB- cord-335975-m6lkrehi 269 24 . . . cord-335975-m6lkrehi 270 1 Twelve twelve CD cord-335975-m6lkrehi 270 2 patients patient NNS cord-335975-m6lkrehi 270 3 received receive VBD cord-335975-m6lkrehi 270 4 saline saline NN cord-335975-m6lkrehi 270 5 and and CC cord-335975-m6lkrehi 270 6 10 10 CD cord-335975-m6lkrehi 270 7 received receive VBD cord-335975-m6lkrehi 270 8 albumin albumin NN cord-335975-m6lkrehi 270 9 . . . cord-335975-m6lkrehi 271 1 Apart apart RB cord-335975-m6lkrehi 271 2 from from IN cord-335975-m6lkrehi 271 3 age age NN cord-335975-m6lkrehi 271 4 , , , cord-335975-m6lkrehi 271 5 no no DT cord-335975-m6lkrehi 271 6 statistical statistical JJ cord-335975-m6lkrehi 271 7 difference difference NN cord-335975-m6lkrehi 271 8 was be VBD cord-335975-m6lkrehi 271 9 found find VBN cord-335975-m6lkrehi 271 10 between between IN cord-335975-m6lkrehi 271 11 groups group NNS cord-335975-m6lkrehi 271 12 regarding regard VBG cord-335975-m6lkrehi 271 13 demographic demographic JJ cord-335975-m6lkrehi 271 14 characteristics characteristic NNS cord-335975-m6lkrehi 271 15 and and CC cord-335975-m6lkrehi 271 16 baseline baseline JJ cord-335975-m6lkrehi 271 17 hemodynamic hemodynamic JJ cord-335975-m6lkrehi 271 18 parameters parameter NNS cord-335975-m6lkrehi 271 19 . . . cord-335975-m6lkrehi 272 1 Norepinephrine norepinephrine NN cord-335975-m6lkrehi 272 2 dose dose NN cord-335975-m6lkrehi 272 3 and and CC cord-335975-m6lkrehi 272 4 mean mean JJ cord-335975-m6lkrehi 272 5 volume volume NN cord-335975-m6lkrehi 272 6 of of IN cord-335975-m6lkrehi 272 7 infused infuse VBN cord-335975-m6lkrehi 272 8 fluid fluid NN cord-335975-m6lkrehi 272 9 before before IN cord-335975-m6lkrehi 272 10 inclusion inclusion NN cord-335975-m6lkrehi 272 11 was be VBD cord-335975-m6lkrehi 272 12 not not RB cord-335975-m6lkrehi 272 13 different different JJ cord-335975-m6lkrehi 272 14 between between IN cord-335975-m6lkrehi 272 15 groups group NNS cord-335975-m6lkrehi 272 16 ( ( -LRB- cord-335975-m6lkrehi 272 17 Table table NN cord-335975-m6lkrehi 272 18 1 1 CD cord-335975-m6lkrehi 272 19 ) ) -RRB- cord-335975-m6lkrehi 272 20 . . . cord-335975-m6lkrehi 273 1 Before before IN cord-335975-m6lkrehi 273 2 fluid fluid JJ cord-335975-m6lkrehi 273 3 replacement replacement NN cord-335975-m6lkrehi 273 4 , , , cord-335975-m6lkrehi 273 5 endothelial endothelial JJ cord-335975-m6lkrehi 273 6 response response NN cord-335975-m6lkrehi 273 7 to to IN cord-335975-m6lkrehi 273 8 acetylcholine acetylcholine NN cord-335975-m6lkrehi 273 9 iontophoresis iontophoresis NN cord-335975-m6lkrehi 273 10 was be VBD cord-335975-m6lkrehi 273 11 not not RB cord-335975-m6lkrehi 273 12 different different JJ cord-335975-m6lkrehi 273 13 between between IN cord-335975-m6lkrehi 273 14 groups group NNS cord-335975-m6lkrehi 273 15 ( ( -LRB- cord-335975-m6lkrehi 273 16 AUC AUC NNP cord-335975-m6lkrehi 273 17 3514 3514 CD cord-335975-m6lkrehi 273 18 vs vs IN cord-335975-m6lkrehi 273 19 3378 3378 CD cord-335975-m6lkrehi 273 20 ; ; : cord-335975-m6lkrehi 273 21 p p NN cord-335975-m6lkrehi 273 22 = = SYM cord-335975-m6lkrehi 273 23 0.16 0.16 CD cord-335975-m6lkrehi 273 24 ) ) -RRB- cord-335975-m6lkrehi 273 25 . . . cord-335975-m6lkrehi 274 1 Volume volume NN cord-335975-m6lkrehi 274 2 expansion expansion NN cord-335975-m6lkrehi 274 3 induced induce VBD cord-335975-m6lkrehi 274 4 a a DT cord-335975-m6lkrehi 274 5 slight slight JJ cord-335975-m6lkrehi 274 6 increase increase NN cord-335975-m6lkrehi 274 7 of of IN cord-335975-m6lkrehi 274 8 systolic systolic JJ cord-335975-m6lkrehi 274 9 arterial arterial JJ cord-335975-m6lkrehi 274 10 pressure pressure NN cord-335975-m6lkrehi 274 11 , , , cord-335975-m6lkrehi 274 12 significantly significantly RB cord-335975-m6lkrehi 274 13 higher high JJR cord-335975-m6lkrehi 274 14 in in IN cord-335975-m6lkrehi 274 15 the the DT cord-335975-m6lkrehi 274 16 albumin albumin NN cord-335975-m6lkrehi 274 17 group group NN cord-335975-m6lkrehi 274 18 ( ( -LRB- cord-335975-m6lkrehi 274 19 7 7 CD cord-335975-m6lkrehi 274 20 vs vs IN cord-335975-m6lkrehi 274 21 2 2 CD cord-335975-m6lkrehi 274 22 % % NN cord-335975-m6lkrehi 274 23 ; ; : cord-335975-m6lkrehi 274 24 p p NN cord-335975-m6lkrehi 274 25 = = SYM cord-335975-m6lkrehi 274 26 0.02 0.02 CD cord-335975-m6lkrehi 274 27 ) ) -RRB- cord-335975-m6lkrehi 274 28 with with IN cord-335975-m6lkrehi 274 29 no no DT cord-335975-m6lkrehi 274 30 difference difference NN cord-335975-m6lkrehi 274 31 regarding regard VBG cord-335975-m6lkrehi 274 32 cardiac cardiac JJ cord-335975-m6lkrehi 274 33 output output NN cord-335975-m6lkrehi 274 34 variations variation NNS cord-335975-m6lkrehi 274 35 between between IN cord-335975-m6lkrehi 274 36 groups group NNS cord-335975-m6lkrehi 274 37 . . . cord-335975-m6lkrehi 275 1 Next next RB cord-335975-m6lkrehi 275 2 , , , cord-335975-m6lkrehi 275 3 we -PRON- PRP cord-335975-m6lkrehi 275 4 compared compare VBD cord-335975-m6lkrehi 275 5 the the DT cord-335975-m6lkrehi 275 6 variations variation NNS cord-335975-m6lkrehi 275 7 of of IN cord-335975-m6lkrehi 275 8 endothelium endothelium NN cord-335975-m6lkrehi 275 9 response response NN cord-335975-m6lkrehi 275 10 to to IN cord-335975-m6lkrehi 275 11 iontophoresis iontophoresis NN cord-335975-m6lkrehi 275 12 before before IN cord-335975-m6lkrehi 275 13 and and CC cord-335975-m6lkrehi 275 14 after after IN cord-335975-m6lkrehi 275 15 fluid fluid JJ cord-335975-m6lkrehi 275 16 infusion infusion NN cord-335975-m6lkrehi 275 17 . . . cord-335975-m6lkrehi 276 1 The the DT cord-335975-m6lkrehi 276 2 improvement improvement NN cord-335975-m6lkrehi 276 3 of of IN cord-335975-m6lkrehi 276 4 endothelial endothelial JJ cord-335975-m6lkrehi 276 5 response response NN cord-335975-m6lkrehi 276 6 after after IN cord-335975-m6lkrehi 276 7 acetylcholine acetylcholine NN cord-335975-m6lkrehi 276 8 challenge challenge NN cord-335975-m6lkrehi 276 9 was be VBD cord-335975-m6lkrehi 276 10 significantly significantly RB cord-335975-m6lkrehi 276 11 higher high JJR cord-335975-m6lkrehi 276 12 in in IN cord-335975-m6lkrehi 276 13 the the DT cord-335975-m6lkrehi 276 14 albumin albumin NN cord-335975-m6lkrehi 276 15 group group NN cord-335975-m6lkrehi 276 16 ( ( -LRB- cord-335975-m6lkrehi 276 17 196 196 CD cord-335975-m6lkrehi 276 18 vs vs IN cord-335975-m6lkrehi 276 19 44 44 CD cord-335975-m6lkrehi 276 20 % % NN cord-335975-m6lkrehi 276 21 , , , cord-335975-m6lkrehi 276 22 p p NN cord-335975-m6lkrehi 276 23 = = SYM cord-335975-m6lkrehi 276 24 0.01 0.01 CD cord-335975-m6lkrehi 276 25 ) ) -RRB- cord-335975-m6lkrehi 276 26 . . . cord-335975-m6lkrehi 277 1 Conclusion conclusion NN cord-335975-m6lkrehi 277 2 : : : cord-335975-m6lkrehi 278 1 In in IN cord-335975-m6lkrehi 278 2 the the DT cord-335975-m6lkrehi 278 3 early early JJ cord-335975-m6lkrehi 278 4 stage stage NN cord-335975-m6lkrehi 278 5 of of IN cord-335975-m6lkrehi 278 6 septic septic JJ cord-335975-m6lkrehi 278 7 shock shock NN cord-335975-m6lkrehi 278 8 resuscitation resuscitation NN cord-335975-m6lkrehi 278 9 , , , cord-335975-m6lkrehi 278 10 we -PRON- PRP cord-335975-m6lkrehi 278 11 showed show VBD cord-335975-m6lkrehi 278 12 that that IN cord-335975-m6lkrehi 278 13 albumin albumin NN cord-335975-m6lkrehi 278 14 infusion infusion NN cord-335975-m6lkrehi 278 15 had have VBD cord-335975-m6lkrehi 278 16 protective protective JJ cord-335975-m6lkrehi 278 17 endothelial endothelial JJ cord-335975-m6lkrehi 278 18 effects effect NNS cord-335975-m6lkrehi 278 19 . . . cord-335975-m6lkrehi 279 1 This this DT cord-335975-m6lkrehi 279 2 result result NN cord-335975-m6lkrehi 279 3 has have VBZ cord-335975-m6lkrehi 279 4 to to TO cord-335975-m6lkrehi 279 5 be be VB cord-335975-m6lkrehi 279 6 confirmed confirm VBN cord-335975-m6lkrehi 279 7 in in IN cord-335975-m6lkrehi 279 8 a a DT cord-335975-m6lkrehi 279 9 larger large JJR cord-335975-m6lkrehi 279 10 cohort cohort NN cord-335975-m6lkrehi 279 11 . . . cord-335975-m6lkrehi 280 1 418 418 LS cord-335975-m6lkrehi 280 2 ] ] -RRB- cord-335975-m6lkrehi 280 3 + + SYM cord-335975-m6lkrehi 280 4 all all DT cord-335975-m6lkrehi 280 5 p p XX cord-335975-m6lkrehi 280 6 < < XX cord-335975-m6lkrehi 280 7 .001 .001 CD cord-335975-m6lkrehi 280 8 ) ) -RRB- cord-335975-m6lkrehi 280 9 . . . cord-335975-m6lkrehi 281 1 We -PRON- PRP cord-335975-m6lkrehi 281 2 found find VBD cord-335975-m6lkrehi 281 3 no no DT cord-335975-m6lkrehi 281 4 correlation correlation NN cord-335975-m6lkrehi 281 5 between between IN cord-335975-m6lkrehi 281 6 cognitive cognitive JJ cord-335975-m6lkrehi 281 7 scores score NNS cord-335975-m6lkrehi 281 8 at at IN cord-335975-m6lkrehi 281 9 hospital hospital NN cord-335975-m6lkrehi 281 10 discharge discharge NN cord-335975-m6lkrehi 281 11 and and CC cord-335975-m6lkrehi 281 12 the the DT cord-335975-m6lkrehi 281 13 severity severity NN cord-335975-m6lkrehi 281 14 of of IN cord-335975-m6lkrehi 281 15 EEG EEG NNP cord-335975-m6lkrehi 281 16 - - HYPH cord-335975-m6lkrehi 281 17 defined define VBN cord-335975-m6lkrehi 281 18 encephalopathy encephalopathy NN cord-335975-m6lkrehi 281 19 during during IN cord-335975-m6lkrehi 281 20 the the DT cord-335975-m6lkrehi 281 21 7 7 CD cord-335975-m6lkrehi 281 22 days day NNS cord-335975-m6lkrehi 281 23 of of IN cord-335975-m6lkrehi 281 24 ICU ICU NNP cord-335975-m6lkrehi 281 25 or or CC cord-335975-m6lkrehi 281 26 during during IN cord-335975-m6lkrehi 281 27 the the DT cord-335975-m6lkrehi 281 28 first first JJ cord-335975-m6lkrehi 281 29 48 48 CD cord-335975-m6lkrehi 281 30 h h NN cord-335975-m6lkrehi 281 31 after after IN cord-335975-m6lkrehi 281 32 admission admission NN cord-335975-m6lkrehi 281 33 . . . cord-335975-m6lkrehi 282 1 However however RB cord-335975-m6lkrehi 282 2 , , , cord-335975-m6lkrehi 282 3 sepsis sepsis NN cord-335975-m6lkrehi 282 4 survivors survivor NNS cord-335975-m6lkrehi 282 5 ' ' POS cord-335975-m6lkrehi 282 6 scores score NNS cord-335975-m6lkrehi 282 7 were be VBD cord-335975-m6lkrehi 282 8 lower low JJR cord-335975-m6lkrehi 282 9 than than IN cord-335975-m6lkrehi 282 10 controls control NNS cord-335975-m6lkrehi 282 11 ' ' '' cord-335975-m6lkrehi 283 1 ( ( -LRB- cord-335975-m6lkrehi 283 2 p p NN cord-335975-m6lkrehi 283 3 < < XX cord-335975-m6lkrehi 283 4 .001 .001 CD cord-335975-m6lkrehi 283 5 ) ) -RRB- cord-335975-m6lkrehi 284 1 ( ( -LRB- cord-335975-m6lkrehi 284 2 Table table NN cord-335975-m6lkrehi 284 3 1 1 CD cord-335975-m6lkrehi 284 4 ) ) -RRB- cord-335975-m6lkrehi 284 5 . . . cord-335975-m6lkrehi 285 1 Conclusion conclusion NN cord-335975-m6lkrehi 285 2 : : : cord-335975-m6lkrehi 286 1 In in IN cord-335975-m6lkrehi 286 2 this this DT cord-335975-m6lkrehi 286 3 study study NN cord-335975-m6lkrehi 286 4 , , , cord-335975-m6lkrehi 286 5 EEG EEG NNP cord-335975-m6lkrehi 286 6 was be VBD cord-335975-m6lkrehi 286 7 more more RBR cord-335975-m6lkrehi 286 8 sensitive sensitive JJ cord-335975-m6lkrehi 286 9 than than IN cord-335975-m6lkrehi 286 10 clinical clinical JJ cord-335975-m6lkrehi 286 11 tools tool NNS cord-335975-m6lkrehi 286 12 to to TO cord-335975-m6lkrehi 286 13 detect detect VB cord-335975-m6lkrehi 286 14 SAE SAE NNP cord-335975-m6lkrehi 286 15 but but CC cord-335975-m6lkrehi 286 16 clinical clinical JJ cord-335975-m6lkrehi 286 17 scales scale NNS cord-335975-m6lkrehi 286 18 correlated correlate VBN cord-335975-m6lkrehi 286 19 with with IN cord-335975-m6lkrehi 286 20 the the DT cord-335975-m6lkrehi 286 21 EEG EEG NNP cord-335975-m6lkrehi 286 22 grade grade NN cord-335975-m6lkrehi 286 23 . . . cord-335975-m6lkrehi 287 1 Encephalopathy encephalopathy NN cord-335975-m6lkrehi 287 2 was be VBD cord-335975-m6lkrehi 287 3 not not RB cord-335975-m6lkrehi 287 4 associated associate VBN cord-335975-m6lkrehi 287 5 with with IN cord-335975-m6lkrehi 287 6 short short JJ cord-335975-m6lkrehi 287 7 - - HYPH cord-335975-m6lkrehi 287 8 term term NN cord-335975-m6lkrehi 287 9 cognitive cognitive JJ cord-335975-m6lkrehi 287 10 function function NN cord-335975-m6lkrehi 287 11 . . . cord-335975-m6lkrehi 288 1 Further further JJ cord-335975-m6lkrehi 288 2 study study NN cord-335975-m6lkrehi 288 3 and and CC cord-335975-m6lkrehi 288 4 a a DT cord-335975-m6lkrehi 288 5 larger large JJR cord-335975-m6lkrehi 288 6 cohort cohort NN cord-335975-m6lkrehi 288 7 are be VBP cord-335975-m6lkrehi 288 8 needed need VBN cord-335975-m6lkrehi 288 9 to to TO cord-335975-m6lkrehi 288 10 determine determine VB cord-335975-m6lkrehi 288 11 which which WDT cord-335975-m6lkrehi 288 12 early early JJ cord-335975-m6lkrehi 288 13 EEG EEG NNP cord-335975-m6lkrehi 288 14 Introduction introduction NN cord-335975-m6lkrehi 288 15 : : : cord-335975-m6lkrehi 289 1 There there EX cord-335975-m6lkrehi 289 2 is be VBZ cord-335975-m6lkrehi 289 3 growing grow VBG cord-335975-m6lkrehi 289 4 evidence evidence NN cord-335975-m6lkrehi 289 5 that that IN cord-335975-m6lkrehi 289 6 corticotherapy corticotherapy NNP cord-335975-m6lkrehi 289 7 improves improve VBZ cord-335975-m6lkrehi 289 8 survival survival NN cord-335975-m6lkrehi 289 9 from from IN cord-335975-m6lkrehi 289 10 septic septic JJ cord-335975-m6lkrehi 289 11 shock shock NN cord-335975-m6lkrehi 289 12 . . . cord-335975-m6lkrehi 290 1 This this DT cord-335975-m6lkrehi 290 2 observational observational JJ cord-335975-m6lkrehi 290 3 study study NN cord-335975-m6lkrehi 290 4 aimed aim VBN cord-335975-m6lkrehi 290 5 at at IN cord-335975-m6lkrehi 290 6 evaluating evaluate VBG cord-335975-m6lkrehi 290 7 at at IN cord-335975-m6lkrehi 290 8 bedside bedside NN cord-335975-m6lkrehi 290 9 resistance resistance NN cord-335975-m6lkrehi 290 10 to to IN cord-335975-m6lkrehi 290 11 corticosteroids corticosteroid NNS cord-335975-m6lkrehi 290 12 in in IN cord-335975-m6lkrehi 290 13 adults adult NNS cord-335975-m6lkrehi 290 14 with with IN cord-335975-m6lkrehi 290 15 sepsis sepsis NN cord-335975-m6lkrehi 290 16 . . . cord-335975-m6lkrehi 291 1 Patients patient NNS cord-335975-m6lkrehi 291 2 and and CC cord-335975-m6lkrehi 291 3 methods method NNS cord-335975-m6lkrehi 291 4 : : : cord-335975-m6lkrehi 291 5 Participants participant NNS cord-335975-m6lkrehi 291 6 - - HYPH cord-335975-m6lkrehi 291 7 ICU ICU NNP cord-335975-m6lkrehi 291 8 adults adult NNS cord-335975-m6lkrehi 291 9 with with IN cord-335975-m6lkrehi 291 10 septic septic JJ cord-335975-m6lkrehi 291 11 shock shock NN cord-335975-m6lkrehi 291 12 or or CC cord-335975-m6lkrehi 291 13 without without IN cord-335975-m6lkrehi 291 14 sepsis sepsis NN cord-335975-m6lkrehi 291 15 admitted admit VBN cord-335975-m6lkrehi 291 16 to to IN cord-335975-m6lkrehi 291 17 the the DT cord-335975-m6lkrehi 291 18 Raymond Raymond NNP cord-335975-m6lkrehi 291 19 Poincaré Poincaré NNP cord-335975-m6lkrehi 291 20 university university NN cord-335975-m6lkrehi 291 21 hospital hospital NN cord-335975-m6lkrehi 291 22 . . . cord-335975-m6lkrehi 292 1 We -PRON- PRP cord-335975-m6lkrehi 292 2 also also RB cord-335975-m6lkrehi 292 3 evaluated evaluate VBD cord-335975-m6lkrehi 292 4 10 10 CD cord-335975-m6lkrehi 292 5 healthy healthy JJ cord-335975-m6lkrehi 292 6 controls control NNS cord-335975-m6lkrehi 292 7 . . . cord-335975-m6lkrehi 293 1 Intervention intervention NN cord-335975-m6lkrehi 293 2 - - HYPH cord-335975-m6lkrehi 293 3 resistance resistance NN cord-335975-m6lkrehi 293 4 to to IN cord-335975-m6lkrehi 293 5 corticosteroids corticosteroid NNS cord-335975-m6lkrehi 293 6 was be VBD cord-335975-m6lkrehi 293 7 assessed assess VBN cord-335975-m6lkrehi 293 8 using use VBG cord-335975-m6lkrehi 293 9 a a DT cord-335975-m6lkrehi 293 10 skin skin NN cord-335975-m6lkrehi 293 11 test test NN cord-335975-m6lkrehi 293 12 . . . cord-335975-m6lkrehi 294 1 10 10 CD cord-335975-m6lkrehi 294 2 µl µl IN cord-335975-m6lkrehi 294 3 of of IN cord-335975-m6lkrehi 294 4 dermocorticoid dermocorticoid NNP cord-335975-m6lkrehi 294 5 cream cream NN cord-335975-m6lkrehi 294 6 ( ( -LRB- cord-335975-m6lkrehi 294 7 class class NN cord-335975-m6lkrehi 294 8 III III NNP cord-335975-m6lkrehi 294 9 , , , cord-335975-m6lkrehi 294 10 Betamethasone Betamethasone NNP cord-335975-m6lkrehi 294 11 ) ) -RRB- cord-335975-m6lkrehi 294 12 was be VBD cord-335975-m6lkrehi 294 13 applied apply VBN cord-335975-m6lkrehi 294 14 on on IN cord-335975-m6lkrehi 294 15 a a DT cord-335975-m6lkrehi 294 16 3 3 CD cord-335975-m6lkrehi 294 17 cm cm NN cord-335975-m6lkrehi 294 18 2 2 CD cord-335975-m6lkrehi 294 19 surface surface NN cord-335975-m6lkrehi 294 20 of of IN cord-335975-m6lkrehi 294 21 the the DT cord-335975-m6lkrehi 294 22 skin skin NN cord-335975-m6lkrehi 294 23 . . . cord-335975-m6lkrehi 295 1 At at IN cord-335975-m6lkrehi 295 2 24 24 CD cord-335975-m6lkrehi 295 3 h h NN cord-335975-m6lkrehi 295 4 , , , cord-335975-m6lkrehi 295 5 two two CD cord-335975-m6lkrehi 295 6 independent independent JJ cord-335975-m6lkrehi 295 7 physicians physician NNS cord-335975-m6lkrehi 295 8 scored score VBD cord-335975-m6lkrehi 295 9 the the DT cord-335975-m6lkrehi 295 10 blanching blanching NN cord-335975-m6lkrehi 295 11 of of IN cord-335975-m6lkrehi 295 12 the the DT cord-335975-m6lkrehi 295 13 skin skin NN cord-335975-m6lkrehi 295 14 from from IN cord-335975-m6lkrehi 295 15 0 0 CD cord-335975-m6lkrehi 295 16 to to IN cord-335975-m6lkrehi 295 17 4 4 CD cord-335975-m6lkrehi 295 18 - - HYPH cord-335975-m6lkrehi 295 19 0-no 0-no CD cord-335975-m6lkrehi 295 20 blanching blanching NN cord-335975-m6lkrehi 295 21 + + CC cord-335975-m6lkrehi 296 1 1- 1- LS cord-335975-m6lkrehi 296 2 < < XX cord-335975-m6lkrehi 296 3 50 50 CD cord-335975-m6lkrehi 296 4 % % NN cord-335975-m6lkrehi 296 5 of of IN cord-335975-m6lkrehi 296 6 surface surface NN cord-335975-m6lkrehi 296 7 + + SYM cord-335975-m6lkrehi 296 8 2 2 CD cord-335975-m6lkrehi 296 9 - - SYM cord-335975-m6lkrehi 296 10 50 50 CD cord-335975-m6lkrehi 296 11 to to TO cord-335975-m6lkrehi 296 12 75 75 CD cord-335975-m6lkrehi 296 13 % % NN cord-335975-m6lkrehi 296 14 of of IN cord-335975-m6lkrehi 296 15 surface surface NN cord-335975-m6lkrehi 297 1 + + CC cord-335975-m6lkrehi 297 2 3 3 CD cord-335975-m6lkrehi 297 3 - - SYM cord-335975-m6lkrehi 297 4 75 75 CD cord-335975-m6lkrehi 297 5 to to TO cord-335975-m6lkrehi 297 6 100 100 CD cord-335975-m6lkrehi 297 7 % % NN cord-335975-m6lkrehi 297 8 of of IN cord-335975-m6lkrehi 297 9 surface surface NN cord-335975-m6lkrehi 297 10 , , , cord-335975-m6lkrehi 297 11 and and CC cord-335975-m6lkrehi 297 12 4-blanching 4-blanching CD cord-335975-m6lkrehi 297 13 beyond beyond IN cord-335975-m6lkrehi 297 14 application application NN cord-335975-m6lkrehi 297 15 area area NN cord-335975-m6lkrehi 297 16 . . . cord-335975-m6lkrehi 298 1 Cohen Cohen NNP cord-335975-m6lkrehi 298 2 's 's POS cord-335975-m6lkrehi 298 3 kappa kappa NN cord-335975-m6lkrehi 298 4 was be VBD cord-335975-m6lkrehi 298 5 used use VBN cord-335975-m6lkrehi 298 6 to to TO cord-335975-m6lkrehi 298 7 measure measure VB cord-335975-m6lkrehi 298 8 concordance concordance NN cord-335975-m6lkrehi 298 9 . . . cord-335975-m6lkrehi 299 1 A a DT cord-335975-m6lkrehi 299 2 mean mean JJ cord-335975-m6lkrehi 299 3 score score NN cord-335975-m6lkrehi 299 4 of of IN cord-335975-m6lkrehi 299 5 < < NNP cord-335975-m6lkrehi 299 6 2 2 CD cord-335975-m6lkrehi 299 7 indicated indicate VBD cord-335975-m6lkrehi 299 8 corticoresistance corticoresistance NN cord-335975-m6lkrehi 299 9 and and CC cord-335975-m6lkrehi 299 10 a a DT cord-335975-m6lkrehi 299 11 score score NN cord-335975-m6lkrehi 299 12 of of IN cord-335975-m6lkrehi 299 13 4 4 CD cord-335975-m6lkrehi 299 14 indicating indicate VBG cord-335975-m6lkrehi 299 15 normal normal JJ cord-335975-m6lkrehi 299 16 sensitivity sensitivity NN cord-335975-m6lkrehi 299 17 to to IN cord-335975-m6lkrehi 299 18 corticosteroids corticosteroid NNS cord-335975-m6lkrehi 299 19 . . . cord-335975-m6lkrehi 300 1 We -PRON- PRP cord-335975-m6lkrehi 300 2 also also RB cord-335975-m6lkrehi 300 3 performed perform VBD cord-335975-m6lkrehi 300 4 a a DT cord-335975-m6lkrehi 300 5 250 250 CD cord-335975-m6lkrehi 300 6 µg µg IN cord-335975-m6lkrehi 300 7 ACTH ACTH NNP cord-335975-m6lkrehi 300 8 test test NN cord-335975-m6lkrehi 300 9 . . . cord-335975-m6lkrehi 301 1 Results result NNS cord-335975-m6lkrehi 301 2 : : : cord-335975-m6lkrehi 302 1 We -PRON- PRP cord-335975-m6lkrehi 302 2 enrolled enrol VBD cord-335975-m6lkrehi 302 3 110 110 CD cord-335975-m6lkrehi 302 4 patients patient NNS cord-335975-m6lkrehi 302 5 , , , cord-335975-m6lkrehi 302 6 47 47 CD cord-335975-m6lkrehi 302 7 patients patient NNS cord-335975-m6lkrehi 302 8 with with IN cord-335975-m6lkrehi 302 9 septic septic JJ cord-335975-m6lkrehi 302 10 shock shock NN cord-335975-m6lkrehi 302 11 ( ( -LRB- cord-335975-m6lkrehi 302 12 22 22 CD cord-335975-m6lkrehi 302 13 males male NNS cord-335975-m6lkrehi 302 14 , , , cord-335975-m6lkrehi 302 15 ) ) -RRB- cord-335975-m6lkrehi 302 16 and and CC cord-335975-m6lkrehi 302 17 63 63 CD cord-335975-m6lkrehi 302 18 patients patient NNS cord-335975-m6lkrehi 302 19 without without IN cord-335975-m6lkrehi 302 20 sepsis sepsis NN cord-335975-m6lkrehi 302 21 ( ( -LRB- cord-335975-m6lkrehi 302 22 28 28 CD cord-335975-m6lkrehi 302 23 males male NNS cord-335975-m6lkrehi 302 24 , , , cord-335975-m6lkrehi 302 25 ) ) -RRB- cord-335975-m6lkrehi 302 26 . . . cord-335975-m6lkrehi 303 1 Overall overall RB cord-335975-m6lkrehi 303 2 , , , cord-335975-m6lkrehi 303 3 81 81 CD cord-335975-m6lkrehi 303 4 95 95 CD cord-335975-m6lkrehi 303 5 ( ( -LRB- cord-335975-m6lkrehi 303 6 85 85 CD cord-335975-m6lkrehi 303 7 % % NN cord-335975-m6lkrehi 303 8 ) ) -RRB- cord-335975-m6lkrehi 303 9 with with IN cord-335975-m6lkrehi 303 10 two two CD cord-335975-m6lkrehi 303 11 measurements measurement NNS cord-335975-m6lkrehi 303 12 patients patient NNS cord-335975-m6lkrehi 303 13 had have VBD cord-335975-m6lkrehi 303 14 concordant concordant JJ cord-335975-m6lkrehi 303 15 evaluation evaluation NN cord-335975-m6lkrehi 303 16 of of IN cord-335975-m6lkrehi 303 17 score score NN cord-335975-m6lkrehi 303 18 by by IN cord-335975-m6lkrehi 303 19 the the DT cord-335975-m6lkrehi 303 20 two two CD cord-335975-m6lkrehi 303 21 physicians physician NNS cord-335975-m6lkrehi 303 22 + + CC cord-335975-m6lkrehi 303 23 while while IN cord-335975-m6lkrehi 303 24 14 14 CD cord-335975-m6lkrehi 303 25 had have VBD cord-335975-m6lkrehi 303 26 a a DT cord-335975-m6lkrehi 303 27 difference difference NN cord-335975-m6lkrehi 303 28 of of IN cord-335975-m6lkrehi 303 29 1-point 1-point CD cord-335975-m6lkrehi 303 30 in in IN cord-335975-m6lkrehi 303 31 scores score NNS cord-335975-m6lkrehi 303 32 , , , cord-335975-m6lkrehi 303 33 resulting result VBG cord-335975-m6lkrehi 303 34 in in IN cord-335975-m6lkrehi 303 35 a a DT cord-335975-m6lkrehi 303 36 kappa kappa NN cord-335975-m6lkrehi 303 37 of of IN cord-335975-m6lkrehi 303 38 0.78 0.78 CD cord-335975-m6lkrehi 303 39 ( ( -LRB- cord-335975-m6lkrehi 303 40 95 95 CD cord-335975-m6lkrehi 303 41 % % NN cord-335975-m6lkrehi 303 42 CI CI NNP cord-335975-m6lkrehi 303 43 0.65 0.65 CD cord-335975-m6lkrehi 303 44 - - HYPH cord-335975-m6lkrehi 303 45 0.91 0.91 CD cord-335975-m6lkrehi 303 46 ) ) -RRB- cord-335975-m6lkrehi 303 47 . . . cord-335975-m6lkrehi 304 1 In in IN cord-335975-m6lkrehi 304 2 patients patient NNS cord-335975-m6lkrehi 304 3 with with IN cord-335975-m6lkrehi 304 4 septic septic JJ cord-335975-m6lkrehi 304 5 shock shock NN cord-335975-m6lkrehi 304 6 , , , cord-335975-m6lkrehi 304 7 32 32 CD cord-335975-m6lkrehi 304 8 ( ( -LRB- cord-335975-m6lkrehi 304 9 78 78 CD cord-335975-m6lkrehi 304 10 % % NN cord-335975-m6lkrehi 304 11 ) ) -RRB- cord-335975-m6lkrehi 304 12 have have VBP cord-335975-m6lkrehi 304 13 corticoresistance corticoresistance NN cord-335975-m6lkrehi 304 14 , , , cord-335975-m6lkrehi 304 15 i.e. i.e. FW cord-335975-m6lkrehi 304 16 a a DT cord-335975-m6lkrehi 304 17 mean mean JJ cord-335975-m6lkrehi 304 18 score score NN cord-335975-m6lkrehi 304 19 < < XX cord-335975-m6lkrehi 304 20 2 2 CD cord-335975-m6lkrehi 304 21 , , , cord-335975-m6lkrehi 304 22 8 8 CD cord-335975-m6lkrehi 304 23 ( ( -LRB- cord-335975-m6lkrehi 304 24 20 20 CD cord-335975-m6lkrehi 304 25 % % NN cord-335975-m6lkrehi 304 26 ) ) -RRB- cord-335975-m6lkrehi 304 27 a a DT cord-335975-m6lkrehi 304 28 score score NN cord-335975-m6lkrehi 304 29 of of IN cord-335975-m6lkrehi 304 30 2 2 CD cord-335975-m6lkrehi 304 31 or or CC cord-335975-m6lkrehi 304 32 3 3 CD cord-335975-m6lkrehi 304 33 , , , cord-335975-m6lkrehi 304 34 and and CC cord-335975-m6lkrehi 304 35 1 1 CD cord-335975-m6lkrehi 304 36 ( ( -LRB- cord-335975-m6lkrehi 304 37 2 2 CD cord-335975-m6lkrehi 304 38 % % NN cord-335975-m6lkrehi 304 39 ) ) -RRB- cord-335975-m6lkrehi 304 40 has have VBZ cord-335975-m6lkrehi 304 41 normal normal JJ cord-335975-m6lkrehi 304 42 sensitivity sensitivity NN cord-335975-m6lkrehi 304 43 to to IN cord-335975-m6lkrehi 304 44 corticosteroids corticosteroid NNS cord-335975-m6lkrehi 304 45 . . . cord-335975-m6lkrehi 305 1 In in IN cord-335975-m6lkrehi 305 2 non non JJ cord-335975-m6lkrehi 305 3 - - JJ cord-335975-m6lkrehi 305 4 septic septic JJ cord-335975-m6lkrehi 305 5 critically critically RB cord-335975-m6lkrehi 305 6 ill ill RB cord-335975-m6lkrehi 305 7 , , , cord-335975-m6lkrehi 305 8 30 30 CD cord-335975-m6lkrehi 305 9 ( ( -LRB- cord-335975-m6lkrehi 305 10 56 56 CD cord-335975-m6lkrehi 305 11 % % NN cord-335975-m6lkrehi 305 12 ) ) -RRB- cord-335975-m6lkrehi 305 13 have have VBP cord-335975-m6lkrehi 305 14 corticoresistance corticoresistance NN cord-335975-m6lkrehi 305 15 , , , cord-335975-m6lkrehi 305 16 20 20 CD cord-335975-m6lkrehi 305 17 ( ( -LRB- cord-335975-m6lkrehi 305 18 37 37 CD cord-335975-m6lkrehi 305 19 % % NN cord-335975-m6lkrehi 305 20 ) ) -RRB- cord-335975-m6lkrehi 306 1 a a DT cord-335975-m6lkrehi 306 2 mean mean JJ cord-335975-m6lkrehi 306 3 score score NN cord-335975-m6lkrehi 306 4 of of IN cord-335975-m6lkrehi 306 5 2 2 CD cord-335975-m6lkrehi 306 6 - - SYM cord-335975-m6lkrehi 306 7 3 3 CD cord-335975-m6lkrehi 306 8 , , , cord-335975-m6lkrehi 306 9 and and CC cord-335975-m6lkrehi 306 10 4 4 CD cord-335975-m6lkrehi 306 11 ( ( -LRB- cord-335975-m6lkrehi 306 12 7 7 CD cord-335975-m6lkrehi 306 13 % % NN cord-335975-m6lkrehi 306 14 ) ) -RRB- cord-335975-m6lkrehi 306 15 have have VBP cord-335975-m6lkrehi 306 16 normal normal JJ cord-335975-m6lkrehi 306 17 sensitivity sensitivity NN cord-335975-m6lkrehi 306 18 to to IN cord-335975-m6lkrehi 306 19 corticosteroids corticosteroid NNS cord-335975-m6lkrehi 306 20 . . . cord-335975-m6lkrehi 307 1 Hence hence RB cord-335975-m6lkrehi 307 2 , , , cord-335975-m6lkrehi 307 3 as as IN cord-335975-m6lkrehi 307 4 compared compare VBN cord-335975-m6lkrehi 307 5 to to IN cord-335975-m6lkrehi 307 6 non non JJ cord-335975-m6lkrehi 307 7 - - JJ cord-335975-m6lkrehi 307 8 septic septic JJ cord-335975-m6lkrehi 307 9 patients patient NNS cord-335975-m6lkrehi 307 10 , , , cord-335975-m6lkrehi 307 11 patients patient NNS cord-335975-m6lkrehi 307 12 with with IN cord-335975-m6lkrehi 307 13 septic septic JJ cord-335975-m6lkrehi 307 14 shock shock NN cord-335975-m6lkrehi 307 15 were be VBD cord-335975-m6lkrehi 307 16 more more RBR cord-335975-m6lkrehi 307 17 likely likely JJ cord-335975-m6lkrehi 307 18 to to TO cord-335975-m6lkrehi 307 19 have have VB cord-335975-m6lkrehi 307 20 corticoresistance corticoresistance NNP cord-335975-m6lkrehi 307 21 ( ( -LRB- cord-335975-m6lkrehi 307 22 p p NN cord-335975-m6lkrehi 307 23 = = SYM cord-335975-m6lkrehi 307 24 0.04 0.04 CD cord-335975-m6lkrehi 307 25 ) ) -RRB- cord-335975-m6lkrehi 307 26 . . . cord-335975-m6lkrehi 308 1 Discussion discussion NN cord-335975-m6lkrehi 308 2 : : : cord-335975-m6lkrehi 309 1 Topic topic NN cord-335975-m6lkrehi 309 2 application application NN cord-335975-m6lkrehi 309 3 of of IN cord-335975-m6lkrehi 309 4 corticosteroids corticosteroid NNS cord-335975-m6lkrehi 309 5 on on IN cord-335975-m6lkrehi 309 6 the the DT cord-335975-m6lkrehi 309 7 skin skin NN cord-335975-m6lkrehi 309 8 results result NNS cord-335975-m6lkrehi 309 9 in in IN cord-335975-m6lkrehi 309 10 activation activation NN cord-335975-m6lkrehi 309 11 of of IN cord-335975-m6lkrehi 309 12 glucocorticoid glucocorticoid NN cord-335975-m6lkrehi 309 13 receptors receptor NNS cord-335975-m6lkrehi 309 14 present present JJ cord-335975-m6lkrehi 309 15 within within IN cord-335975-m6lkrehi 309 16 the the DT cord-335975-m6lkrehi 309 17 vessels vessel NNS cord-335975-m6lkrehi 309 18 . . . cord-335975-m6lkrehi 310 1 Subsequently subsequently RB cord-335975-m6lkrehi 310 2 , , , cord-335975-m6lkrehi 310 3 activation activation NN cord-335975-m6lkrehi 310 4 of of IN cord-335975-m6lkrehi 310 5 lipocortin lipocortin NNP cord-335975-m6lkrehi 310 6 1 1 CD cord-335975-m6lkrehi 310 7 may may MD cord-335975-m6lkrehi 310 8 inhibit inhibit VB cord-335975-m6lkrehi 310 9 the the DT cord-335975-m6lkrehi 310 10 activity activity NN cord-335975-m6lkrehi 310 11 of of IN cord-335975-m6lkrehi 310 12 phospholipase phospholipase NNP cord-335975-m6lkrehi 310 13 A2 A2 NNP cord-335975-m6lkrehi 310 14 , , , cord-335975-m6lkrehi 310 15 regulator regulator NN cord-335975-m6lkrehi 310 16 of of IN cord-335975-m6lkrehi 310 17 prostaglandins prostaglandin NNS cord-335975-m6lkrehi 310 18 , , , cord-335975-m6lkrehi 310 19 leucotrienes leucotriene NNS cord-335975-m6lkrehi 310 20 and and CC cord-335975-m6lkrehi 310 21 platelet platelet NN cord-335975-m6lkrehi 310 22 activating activate VBG cord-335975-m6lkrehi 310 23 factor factor NN cord-335975-m6lkrehi 310 24 . . . cord-335975-m6lkrehi 311 1 Then then RB cord-335975-m6lkrehi 311 2 , , , cord-335975-m6lkrehi 311 3 the the DT cord-335975-m6lkrehi 311 4 coupling coupling NN cord-335975-m6lkrehi 311 5 of of IN cord-335975-m6lkrehi 311 6 alpha alpha NN cord-335975-m6lkrehi 311 7 adrenoreceptors adrenoreceptor NNS cord-335975-m6lkrehi 311 8 to to IN cord-335975-m6lkrehi 311 9 their -PRON- PRP$ cord-335975-m6lkrehi 311 10 agonists agonist NNS cord-335975-m6lkrehi 311 11 is be VBZ cord-335975-m6lkrehi 311 12 potentiated potentiate VBN cord-335975-m6lkrehi 311 13 , , , cord-335975-m6lkrehi 311 14 increasing increase VBG cord-335975-m6lkrehi 311 15 vessels vessel NNS cord-335975-m6lkrehi 311 16 smooth smooth JJ cord-335975-m6lkrehi 311 17 muscles muscle NNS cord-335975-m6lkrehi 311 18 sensitivity sensitivity NN cord-335975-m6lkrehi 311 19 to to IN cord-335975-m6lkrehi 311 20 catecholamines catecholamine NNS cord-335975-m6lkrehi 311 21 . . . cord-335975-m6lkrehi 312 1 The the DT cord-335975-m6lkrehi 312 2 subsequent subsequent JJ cord-335975-m6lkrehi 312 3 local local JJ cord-335975-m6lkrehi 312 4 vasocontriction vasocontriction NN cord-335975-m6lkrehi 312 5 is be VBZ cord-335975-m6lkrehi 312 6 reflected reflect VBN cord-335975-m6lkrehi 312 7 by by IN cord-335975-m6lkrehi 312 8 skin skin NN cord-335975-m6lkrehi 312 9 blanching blanching NN cord-335975-m6lkrehi 312 10 . . . cord-335975-m6lkrehi 313 1 Thus thus RB cord-335975-m6lkrehi 313 2 , , , cord-335975-m6lkrehi 313 3 the the DT cord-335975-m6lkrehi 313 4 observed observed JJ cord-335975-m6lkrehi 313 5 lack lack NN cord-335975-m6lkrehi 313 6 of of IN cord-335975-m6lkrehi 313 7 skin skin NN cord-335975-m6lkrehi 313 8 blanching blanching NN cord-335975-m6lkrehi 313 9 in in IN cord-335975-m6lkrehi 313 10 septic septic JJ cord-335975-m6lkrehi 313 11 patients patient NNS cord-335975-m6lkrehi 313 12 may may MD cord-335975-m6lkrehi 313 13 reflect reflect VB cord-335975-m6lkrehi 313 14 altered alter VBN cord-335975-m6lkrehi 313 15 coupling coupling NN cord-335975-m6lkrehi 313 16 between between IN cord-335975-m6lkrehi 313 17 gluocorticoids gluocorticoid NNS cord-335975-m6lkrehi 313 18 and and CC cord-335975-m6lkrehi 313 19 glucocorticoids glucocorticoid NNS cord-335975-m6lkrehi 313 20 receptors receptor NNS cord-335975-m6lkrehi 313 21 . . . cord-335975-m6lkrehi 314 1 Conclusion conclusion NN cord-335975-m6lkrehi 314 2 : : : cord-335975-m6lkrehi 315 1 Roughly roughly RB cord-335975-m6lkrehi 315 2 one one CD cord-335975-m6lkrehi 315 3 out out IN cord-335975-m6lkrehi 315 4 of of IN cord-335975-m6lkrehi 315 5 two two CD cord-335975-m6lkrehi 315 6 adults adult NNS cord-335975-m6lkrehi 315 7 with with IN cord-335975-m6lkrehi 315 8 septic septic JJ cord-335975-m6lkrehi 315 9 shock shock NN cord-335975-m6lkrehi 315 10 may may MD cord-335975-m6lkrehi 315 11 develop develop VB cord-335975-m6lkrehi 315 12 a a DT cord-335975-m6lkrehi 315 13 resistance resistance NN cord-335975-m6lkrehi 315 14 to to IN cord-335975-m6lkrehi 315 15 corticosteroids corticosteroid NNS cord-335975-m6lkrehi 315 16 as as IN cord-335975-m6lkrehi 315 17 assessed assess VBN cord-335975-m6lkrehi 315 18 by by IN cord-335975-m6lkrehi 315 19 a a DT cord-335975-m6lkrehi 315 20 skin skin NN cord-335975-m6lkrehi 315 21 blanching blanching NN cord-335975-m6lkrehi 315 22 test test NN cord-335975-m6lkrehi 315 23 in in IN cord-335975-m6lkrehi 315 24 response response NN cord-335975-m6lkrehi 315 25 to to IN cord-335975-m6lkrehi 315 26 betamethasone betamethasone NNP cord-335975-m6lkrehi 315 27 . . . cord-335975-m6lkrehi 316 1 Introduction introduction NN cord-335975-m6lkrehi 316 2 : : : cord-335975-m6lkrehi 317 1 Mild mild JJ cord-335975-m6lkrehi 317 2 therapeutic therapeutic JJ cord-335975-m6lkrehi 317 3 hypothermia hypothermia NN cord-335975-m6lkrehi 317 4 , , , cord-335975-m6lkrehi 317 5 currently currently RB cord-335975-m6lkrehi 317 6 recommended recommend VBN cord-335975-m6lkrehi 317 7 in in IN cord-335975-m6lkrehi 317 8 the the DT cord-335975-m6lkrehi 317 9 management management NN cord-335975-m6lkrehi 317 10 of of IN cord-335975-m6lkrehi 317 11 cardiac cardiac JJ cord-335975-m6lkrehi 317 12 arrests arrest NNS cord-335975-m6lkrehi 317 13 with with IN cord-335975-m6lkrehi 317 14 shockable shockable JJ cord-335975-m6lkrehi 317 15 rhythm rhythm NN cord-335975-m6lkrehi 317 16 could could MD cord-335975-m6lkrehi 317 17 promote promote VB cord-335975-m6lkrehi 317 18 infectious infectious JJ cord-335975-m6lkrehi 317 19 complications complication NNS cord-335975-m6lkrehi 317 20 and and CC cord-335975-m6lkrehi 317 21 especially especially RB cord-335975-m6lkrehi 317 22 ventilator ventilator NN cord-335975-m6lkrehi 317 23 - - HYPH cord-335975-m6lkrehi 317 24 associated associate VBN cord-335975-m6lkrehi 317 25 pneumonia pneumonia NN cord-335975-m6lkrehi 317 26 ( ( -LRB- cord-335975-m6lkrehi 317 27 VAP VAP NNP cord-335975-m6lkrehi 317 28 ) ) -RRB- cord-335975-m6lkrehi 317 29 ( ( -LRB- cord-335975-m6lkrehi 317 30 Mongardon Mongardon NNP cord-335975-m6lkrehi 317 31 et et NNP cord-335975-m6lkrehi 317 32 al al NNP cord-335975-m6lkrehi 317 33 . . . cord-335975-m6lkrehi 318 1 Crit Crit NNP cord-335975-m6lkrehi 318 2 Care Care NNP cord-335975-m6lkrehi 318 3 Med Med NNP cord-335975-m6lkrehi 318 4 2011 2011 CD cord-335975-m6lkrehi 318 5 ) ) -RRB- cord-335975-m6lkrehi 318 6 . . . cord-335975-m6lkrehi 319 1 Despite despite IN cord-335975-m6lkrehi 319 2 high high JJ cord-335975-m6lkrehi 319 3 incidence incidence NN cord-335975-m6lkrehi 319 4 of of IN cord-335975-m6lkrehi 319 5 VAP VAP NNP cord-335975-m6lkrehi 319 6 and and CC cord-335975-m6lkrehi 319 7 retrospective retrospective JJ cord-335975-m6lkrehi 319 8 trials trial NNS cord-335975-m6lkrehi 319 9 suggesting suggest VBG cord-335975-m6lkrehi 319 10 a a DT cord-335975-m6lkrehi 319 11 benefit benefit NN cord-335975-m6lkrehi 319 12 of of IN cord-335975-m6lkrehi 319 13 shortterm shortterm NN cord-335975-m6lkrehi 319 14 ( ( -LRB- cord-335975-m6lkrehi 319 15 48 48 CD cord-335975-m6lkrehi 319 16 h h NN cord-335975-m6lkrehi 319 17 ) ) -RRB- cord-335975-m6lkrehi 319 18 antibiotics antibiotic NNS cord-335975-m6lkrehi 319 19 in in IN cord-335975-m6lkrehi 319 20 this this DT cord-335975-m6lkrehi 319 21 setting setting NN cord-335975-m6lkrehi 319 22 ( ( -LRB- cord-335975-m6lkrehi 319 23 Davies Davies NNP cord-335975-m6lkrehi 319 24 et et NNP cord-335975-m6lkrehi 319 25 al al NNP cord-335975-m6lkrehi 319 26 . . . cord-335975-m6lkrehi 320 1 Resuscitation resuscitation NN cord-335975-m6lkrehi 320 2 2013 2013 CD cord-335975-m6lkrehi 320 3 ) ) -RRB- cord-335975-m6lkrehi 320 4 , , , cord-335975-m6lkrehi 320 5 systematic systematic JJ cord-335975-m6lkrehi 320 6 use use NN cord-335975-m6lkrehi 320 7 of of IN cord-335975-m6lkrehi 320 8 antibiotic antibiotic JJ cord-335975-m6lkrehi 320 9 prophylaxis prophylaxis NN cord-335975-m6lkrehi 320 10 is be VBZ cord-335975-m6lkrehi 320 11 not not RB cord-335975-m6lkrehi 320 12 recommended recommend VBN cord-335975-m6lkrehi 320 13 in in IN cord-335975-m6lkrehi 320 14 patients patient NNS cord-335975-m6lkrehi 320 15 treated treat VBN cord-335975-m6lkrehi 320 16 with with IN cord-335975-m6lkrehi 320 17 mild mild JJ cord-335975-m6lkrehi 320 18 therapeutic therapeutic JJ cord-335975-m6lkrehi 320 19 hypothermia hypothermia NN cord-335975-m6lkrehi 320 20 after after IN cord-335975-m6lkrehi 320 21 cardiac cardiac JJ cord-335975-m6lkrehi 320 22 arrest arrest NN cord-335975-m6lkrehi 320 23 . . . cord-335975-m6lkrehi 321 1 The the DT cord-335975-m6lkrehi 321 2 primary primary JJ cord-335975-m6lkrehi 321 3 objective objective NN cord-335975-m6lkrehi 321 4 was be VBD cord-335975-m6lkrehi 321 5 to to TO cord-335975-m6lkrehi 321 6 demonstrate demonstrate VB cord-335975-m6lkrehi 321 7 that that IN cord-335975-m6lkrehi 321 8 systematic systematic JJ cord-335975-m6lkrehi 321 9 short short JJ cord-335975-m6lkrehi 321 10 - - HYPH cord-335975-m6lkrehi 321 11 term term NN cord-335975-m6lkrehi 321 12 antibiotic antibiotic JJ cord-335975-m6lkrehi 321 13 prophylaxis prophylaxis NN cord-335975-m6lkrehi 321 14 with with IN cord-335975-m6lkrehi 321 15 amoxicillin amoxicillin NNP cord-335975-m6lkrehi 321 16 - - HYPH cord-335975-m6lkrehi 321 17 clavulanic clavulanic NNP cord-335975-m6lkrehi 321 18 acid acid NN cord-335975-m6lkrehi 321 19 can can MD cord-335975-m6lkrehi 321 20 reduce reduce VB cord-335975-m6lkrehi 321 21 incidence incidence NN cord-335975-m6lkrehi 321 22 of of IN cord-335975-m6lkrehi 321 23 early early JJ cord-335975-m6lkrehi 321 24 VAP VAP NNP cord-335975-m6lkrehi 321 25 ( ( -LRB- cord-335975-m6lkrehi 321 26 < < NNP cord-335975-m6lkrehi 321 27 7 7 CD cord-335975-m6lkrehi 321 28 days day NNS cord-335975-m6lkrehi 321 29 ) ) -RRB- cord-335975-m6lkrehi 321 30 in in IN cord-335975-m6lkrehi 321 31 patients patient NNS cord-335975-m6lkrehi 321 32 treated treat VBN cord-335975-m6lkrehi 321 33 with with IN cord-335975-m6lkrehi 321 34 mild mild JJ cord-335975-m6lkrehi 321 35 therapeutic therapeutic JJ cord-335975-m6lkrehi 321 36 hypothermia hypothermia NN cord-335975-m6lkrehi 321 37 after after IN cord-335975-m6lkrehi 321 38 out out NN cord-335975-m6lkrehi 321 39 - - HYPH cord-335975-m6lkrehi 321 40 of of IN cord-335975-m6lkrehi 321 41 - - HYPH cord-335975-m6lkrehi 321 42 hospital hospital NN cord-335975-m6lkrehi 321 43 cardiac cardiac JJ cord-335975-m6lkrehi 321 44 arrest arrest NN cord-335975-m6lkrehi 321 45 . . . cord-335975-m6lkrehi 322 1 Secondary secondary JJ cord-335975-m6lkrehi 322 2 objectives objective NNS cord-335975-m6lkrehi 322 3 were be VBD cord-335975-m6lkrehi 322 4 its -PRON- PRP$ cord-335975-m6lkrehi 322 5 impact impact NN cord-335975-m6lkrehi 322 6 on on IN cord-335975-m6lkrehi 322 7 incidence incidence NN cord-335975-m6lkrehi 322 8 of of IN cord-335975-m6lkrehi 322 9 late late JJ cord-335975-m6lkrehi 322 10 VAP VAP NNP cord-335975-m6lkrehi 322 11 and and CC cord-335975-m6lkrehi 322 12 on on IN cord-335975-m6lkrehi 322 13 Day Day NNP cord-335975-m6lkrehi 322 14 28 28 CD cord-335975-m6lkrehi 322 15 mortality mortality NN cord-335975-m6lkrehi 322 16 . . . cord-335975-m6lkrehi 323 1 Patients patient NNS cord-335975-m6lkrehi 323 2 and and CC cord-335975-m6lkrehi 323 3 methods method NNS cord-335975-m6lkrehi 323 4 : : : cord-335975-m6lkrehi 323 5 Multicenter multicenter JJ cord-335975-m6lkrehi 323 6 two two CD cord-335975-m6lkrehi 323 7 parallel parallel JJ cord-335975-m6lkrehi 323 8 - - HYPH cord-335975-m6lkrehi 323 9 group group NN cord-335975-m6lkrehi 323 10 doubleblinded doubleblinde VBN cord-335975-m6lkrehi 323 11 randomized randomized JJ cord-335975-m6lkrehi 323 12 trial trial NN cord-335975-m6lkrehi 323 13 . . . cord-335975-m6lkrehi 324 1 Adult adult NN cord-335975-m6lkrehi 324 2 patients patient NNS cord-335975-m6lkrehi 324 3 hospitalized hospitalize VBN cord-335975-m6lkrehi 324 4 in in IN cord-335975-m6lkrehi 324 5 ICU ICU NNP cord-335975-m6lkrehi 324 6 , , , cord-335975-m6lkrehi 324 7 mechanically mechanically RB cord-335975-m6lkrehi 324 8 ventilated ventilate VBN cord-335975-m6lkrehi 324 9 after after IN cord-335975-m6lkrehi 324 10 out out NN cord-335975-m6lkrehi 324 11 - - HYPH cord-335975-m6lkrehi 324 12 of of IN cord-335975-m6lkrehi 324 13 - - HYPH cord-335975-m6lkrehi 324 14 hospital hospital NN cord-335975-m6lkrehi 324 15 resuscitated resuscitate VBD cord-335975-m6lkrehi 324 16 cardiac cardiac JJ cord-335975-m6lkrehi 324 17 arrest arrest NN cord-335975-m6lkrehi 324 18 related relate VBN cord-335975-m6lkrehi 324 19 to to IN cord-335975-m6lkrehi 324 20 initial initial JJ cord-335975-m6lkrehi 324 21 shockable shockable JJ cord-335975-m6lkrehi 324 22 rhythm rhythm NN cord-335975-m6lkrehi 324 23 and and CC cord-335975-m6lkrehi 324 24 treated treat VBN cord-335975-m6lkrehi 324 25 with with IN cord-335975-m6lkrehi 324 26 mild mild JJ cord-335975-m6lkrehi 324 27 therapeutic therapeutic JJ cord-335975-m6lkrehi 324 28 hypothermia hypothermia NN cord-335975-m6lkrehi 324 29 were be VBD cord-335975-m6lkrehi 324 30 eligible eligible JJ cord-335975-m6lkrehi 324 31 . . . cord-335975-m6lkrehi 325 1 Exclusion exclusion NN cord-335975-m6lkrehi 325 2 criteria criterion NNS cord-335975-m6lkrehi 325 3 were be VBD cord-335975-m6lkrehi 325 4 pregnancy pregnancy NN cord-335975-m6lkrehi 325 5 , , , cord-335975-m6lkrehi 325 6 need need VBP cord-335975-m6lkrehi 325 7 for for IN cord-335975-m6lkrehi 325 8 extracorporeal extracorporeal JJ cord-335975-m6lkrehi 325 9 life life NN cord-335975-m6lkrehi 325 10 support support NN cord-335975-m6lkrehi 325 11 , , , cord-335975-m6lkrehi 325 12 ongoing ongoing JJ cord-335975-m6lkrehi 325 13 antibiotic antibiotic JJ cord-335975-m6lkrehi 325 14 therapy therapy NN cord-335975-m6lkrehi 325 15 or or CC cord-335975-m6lkrehi 325 16 pneumonia pneumonia NN cord-335975-m6lkrehi 325 17 , , , cord-335975-m6lkrehi 325 18 known know VBN cord-335975-m6lkrehi 325 19 chronic chronic JJ cord-335975-m6lkrehi 325 20 colonization colonization NN cord-335975-m6lkrehi 325 21 with with IN cord-335975-m6lkrehi 325 22 multiresistant multiresistant JJ cord-335975-m6lkrehi 325 23 bacteria bacteria NNS cord-335975-m6lkrehi 325 24 , , , cord-335975-m6lkrehi 325 25 known know VBN cord-335975-m6lkrehi 325 26 allergy allergy NN cord-335975-m6lkrehi 325 27 to to IN cord-335975-m6lkrehi 325 28 beta beta NN cord-335975-m6lkrehi 325 29 - - HYPH cord-335975-m6lkrehi 325 30 lactam lactam NN cord-335975-m6lkrehi 325 31 antibiotics antibiotic NNS cord-335975-m6lkrehi 325 32 and and CC cord-335975-m6lkrehi 325 33 moribund moribund JJ cord-335975-m6lkrehi 325 34 patients patient NNS cord-335975-m6lkrehi 325 35 . . . cord-335975-m6lkrehi 326 1 Patients patient NNS cord-335975-m6lkrehi 326 2 received receive VBD cord-335975-m6lkrehi 326 3 either either CC cord-335975-m6lkrehi 326 4 intravenous intravenous JJ cord-335975-m6lkrehi 326 5 injection injection NN cord-335975-m6lkrehi 326 6 of of IN cord-335975-m6lkrehi 326 7 amoxicillin amoxicillin NNP cord-335975-m6lkrehi 326 8 - - HYPH cord-335975-m6lkrehi 326 9 clavulanic clavulanic NNP cord-335975-m6lkrehi 326 10 acid acid NN cord-335975-m6lkrehi 326 11 ( ( -LRB- cord-335975-m6lkrehi 326 12 1 1 CD cord-335975-m6lkrehi 326 13 g g NN cord-335975-m6lkrehi 326 14 200 200 CD cord-335975-m6lkrehi 326 15 mg mg NNPS cord-335975-m6lkrehi 326 16 ) ) -RRB- cord-335975-m6lkrehi 326 17 or or CC cord-335975-m6lkrehi 326 18 placebo placebo NN cord-335975-m6lkrehi 326 19 three three CD cord-335975-m6lkrehi 326 20 times time NNS cord-335975-m6lkrehi 326 21 a a DT cord-335975-m6lkrehi 326 22 day day NN cord-335975-m6lkrehi 326 23 for for IN cord-335975-m6lkrehi 326 24 2 2 CD cord-335975-m6lkrehi 326 25 days day NNS cord-335975-m6lkrehi 326 26 . . . cord-335975-m6lkrehi 327 1 The the DT cord-335975-m6lkrehi 327 2 primary primary JJ cord-335975-m6lkrehi 327 3 endpoint endpoint NN cord-335975-m6lkrehi 327 4 was be VBD cord-335975-m6lkrehi 327 5 the the DT cord-335975-m6lkrehi 327 6 onset onset NN cord-335975-m6lkrehi 327 7 of of IN cord-335975-m6lkrehi 327 8 early early JJ cord-335975-m6lkrehi 327 9 VAP VAP NNP cord-335975-m6lkrehi 327 10 . . . cord-335975-m6lkrehi 328 1 All all DT cord-335975-m6lkrehi 328 2 suspected suspect VBN cord-335975-m6lkrehi 328 3 pulmonary pulmonary JJ cord-335975-m6lkrehi 328 4 infections infection NNS cord-335975-m6lkrehi 328 5 were be VBD cord-335975-m6lkrehi 328 6 adjudicated adjudicate VBN cord-335975-m6lkrehi 328 7 by by IN cord-335975-m6lkrehi 328 8 a a DT cord-335975-m6lkrehi 328 9 blinded blinded JJ cord-335975-m6lkrehi 328 10 independent independent JJ cord-335975-m6lkrehi 328 11 committee committee NN cord-335975-m6lkrehi 328 12 . . . cord-335975-m6lkrehi 329 1 Results result NNS cord-335975-m6lkrehi 329 2 : : : cord-335975-m6lkrehi 330 1 Out out IN cord-335975-m6lkrehi 330 2 of of IN cord-335975-m6lkrehi 330 3 198 198 CD cord-335975-m6lkrehi 330 4 patients patient NNS cord-335975-m6lkrehi 330 5 included include VBN cord-335975-m6lkrehi 330 6 , , , cord-335975-m6lkrehi 330 7 196 196 CD cord-335975-m6lkrehi 330 8 were be VBD cord-335975-m6lkrehi 330 9 finally finally RB cord-335975-m6lkrehi 330 10 analyzed analyze VBN cord-335975-m6lkrehi 330 11 , , , cord-335975-m6lkrehi 330 12 99 99 CD cord-335975-m6lkrehi 330 13 in in IN cord-335975-m6lkrehi 330 14 treatment treatment NN cord-335975-m6lkrehi 330 15 group group NN cord-335975-m6lkrehi 330 16 and and CC cord-335975-m6lkrehi 330 17 97 97 CD cord-335975-m6lkrehi 330 18 in in IN cord-335975-m6lkrehi 330 19 placebo placebo NN cord-335975-m6lkrehi 330 20 group group NN cord-335975-m6lkrehi 330 21 ( ( -LRB- cord-335975-m6lkrehi 330 22 mean mean UH cord-335975-m6lkrehi 330 23 age age NN cord-335975-m6lkrehi 330 24 60.5 60.5 CD cord-335975-m6lkrehi 330 25 ± ± CD cord-335975-m6lkrehi 330 26 14.4 14.4 CD cord-335975-m6lkrehi 330 27 years year NNS cord-335975-m6lkrehi 330 28 , , , cord-335975-m6lkrehi 330 29 sex sex NN cord-335975-m6lkrehi 330 30 ratio ratio NN cord-335975-m6lkrehi 330 31 = = SYM cord-335975-m6lkrehi 330 32 4 4 CD cord-335975-m6lkrehi 330 33 , , , cord-335975-m6lkrehi 330 34 SOFA sofa NN cord-335975-m6lkrehi 330 35 score score NN cord-335975-m6lkrehi 330 36 8.7 8.7 CD cord-335975-m6lkrehi 330 37 ± ± NNP cord-335975-m6lkrehi 330 38 3.1 3.1 CD cord-335975-m6lkrehi 330 39 ) ) -RRB- cord-335975-m6lkrehi 330 40 . . . cord-335975-m6lkrehi 331 1 Characteristics characteristic NNS cord-335975-m6lkrehi 331 2 of of IN cord-335975-m6lkrehi 331 3 cardiac cardiac JJ cord-335975-m6lkrehi 331 4 arrest arrest NN cord-335975-m6lkrehi 331 5 were be VBD cord-335975-m6lkrehi 331 6 similar similar JJ cord-335975-m6lkrehi 331 7 in in IN cord-335975-m6lkrehi 331 8 both both DT cord-335975-m6lkrehi 331 9 groups group NNS cord-335975-m6lkrehi 331 10 ( ( -LRB- cord-335975-m6lkrehi 331 11 no no DT cord-335975-m6lkrehi 331 12 flow flow NN cord-335975-m6lkrehi 331 13 = = SYM cord-335975-m6lkrehi 331 14 3.5 3.5 CD cord-335975-m6lkrehi 331 15 ± ± CD cord-335975-m6lkrehi 331 16 4.8 4.8 CD cord-335975-m6lkrehi 331 17 min min NN cord-335975-m6lkrehi 331 18 vs vs IN cord-335975-m6lkrehi 331 19 3.8 3.8 CD cord-335975-m6lkrehi 331 20 ± ± CD cord-335975-m6lkrehi 331 21 4.0 4.0 CD cord-335975-m6lkrehi 331 22 min min NN cord-335975-m6lkrehi 331 23 , , , cord-335975-m6lkrehi 331 24 low low JJ cord-335975-m6lkrehi 331 25 - - HYPH cord-335975-m6lkrehi 331 26 flow flow NN cord-335975-m6lkrehi 331 27 = = NFP cord-335975-m6lkrehi 332 1 21.8 21.8 CD cord-335975-m6lkrehi 332 2 ± ± CD cord-335975-m6lkrehi 332 3 13.7 13.7 CD cord-335975-m6lkrehi 332 4 min min NN cord-335975-m6lkrehi 332 5 vs vs IN cord-335975-m6lkrehi 332 6 18.2 18.2 CD cord-335975-m6lkrehi 332 7 ± ± CD cord-335975-m6lkrehi 332 8 10.1 10.1 CD cord-335975-m6lkrehi 332 9 min min NNP cord-335975-m6lkrehi 332 10 ) ) -RRB- cord-335975-m6lkrehi 332 11 . . . cord-335975-m6lkrehi 333 1 51 51 CD cord-335975-m6lkrehi 334 1 early early JJ cord-335975-m6lkrehi 334 2 VAP VAP NNP cord-335975-m6lkrehi 334 3 were be VBD cord-335975-m6lkrehi 334 4 confirmed confirm VBN cord-335975-m6lkrehi 334 5 , , , cord-335975-m6lkrehi 334 6 19 19 CD cord-335975-m6lkrehi 334 7 in in IN cord-335975-m6lkrehi 334 8 treatment treatment NN cord-335975-m6lkrehi 334 9 group group NN cord-335975-m6lkrehi 334 10 vs vs IN cord-335975-m6lkrehi 334 11 32 32 CD cord-335975-m6lkrehi 334 12 in in IN cord-335975-m6lkrehi 334 13 placebo placebo NN cord-335975-m6lkrehi 334 14 group group NN cord-335975-m6lkrehi 334 15 , , , cord-335975-m6lkrehi 334 16 with with IN cord-335975-m6lkrehi 334 17 an an DT cord-335975-m6lkrehi 334 18 incidence incidence NN cord-335975-m6lkrehi 334 19 of of IN cord-335975-m6lkrehi 334 20 19.2 19.2 CD cord-335975-m6lkrehi 334 21 vs vs IN cord-335975-m6lkrehi 334 22 33.0 33.0 CD cord-335975-m6lkrehi 334 23 % % NN cord-335975-m6lkrehi 334 24 , , , cord-335975-m6lkrehi 334 25 respectively respectively RB cord-335975-m6lkrehi 334 26 ( ( -LRB- cord-335975-m6lkrehi 334 27 HR hr NN cord-335975-m6lkrehi 334 28 = = SYM cord-335975-m6lkrehi 334 29 0.546 0.546 CD cord-335975-m6lkrehi 335 1 + + CC cord-335975-m6lkrehi 335 2 IC IC NNP cord-335975-m6lkrehi 335 3 95 95 CD cord-335975-m6lkrehi 335 4 % % NN cord-335975-m6lkrehi 335 5 = = NFP cord-335975-m6lkrehi 336 1 [ [ -LRB- cord-335975-m6lkrehi 336 2 0.315 0.315 CD cord-335975-m6lkrehi 336 3 + + SYM cord-335975-m6lkrehi 336 4 0.946 0.946 CD cord-335975-m6lkrehi 336 5 ] ] -RRB- cord-335975-m6lkrehi 336 6 , , , cord-335975-m6lkrehi 336 7 p p NN cord-335975-m6lkrehi 336 8 = = SYM cord-335975-m6lkrehi 336 9 0.031 0.031 CD cord-335975-m6lkrehi 336 10 ) ) -RRB- cord-335975-m6lkrehi 337 1 ( ( -LRB- cord-335975-m6lkrehi 337 2 Fig Fig NNP cord-335975-m6lkrehi 337 3 . . . cord-335975-m6lkrehi 338 1 1 1 LS cord-335975-m6lkrehi 338 2 ) ) -RRB- cord-335975-m6lkrehi 338 3 . . . cord-335975-m6lkrehi 339 1 The the DT cord-335975-m6lkrehi 339 2 procedure procedure NN cord-335975-m6lkrehi 339 3 did do VBD cord-335975-m6lkrehi 339 4 not not RB cord-335975-m6lkrehi 339 5 affect affect VB cord-335975-m6lkrehi 339 6 occurrence occurrence NN cord-335975-m6lkrehi 339 7 of of IN cord-335975-m6lkrehi 339 8 late late JJ cord-335975-m6lkrehi 339 9 VAP VAP NNP cord-335975-m6lkrehi 339 10 ( ( -LRB- cord-335975-m6lkrehi 339 11 > > NFP cord-335975-m6lkrehi 339 12 7 7 CD cord-335975-m6lkrehi 339 13 days day NNS cord-335975-m6lkrehi 339 14 ) ) -RRB- cord-335975-m6lkrehi 339 15 , , , cord-335975-m6lkrehi 339 16 respectively respectively RB cord-335975-m6lkrehi 339 17 4 4 CD cord-335975-m6lkrehi 339 18 vs vs IN cord-335975-m6lkrehi 339 19 5 5 CD cord-335975-m6lkrehi 339 20 . . . cord-335975-m6lkrehi 340 1 Day day NN cord-335975-m6lkrehi 340 2 28 28 CD cord-335975-m6lkrehi 340 3 mortality mortality NN cord-335975-m6lkrehi 340 4 was be VBD cord-335975-m6lkrehi 340 5 similar similar JJ cord-335975-m6lkrehi 340 6 in in IN cord-335975-m6lkrehi 340 7 both both DT cord-335975-m6lkrehi 340 8 arms arm NNS cord-335975-m6lkrehi 340 9 ( ( -LRB- cord-335975-m6lkrehi 340 10 41.4 41.4 CD cord-335975-m6lkrehi 340 11 vs vs IN cord-335975-m6lkrehi 340 12 37.5 37.5 CD cord-335975-m6lkrehi 340 13 % % NN cord-335975-m6lkrehi 340 14 , , , cord-335975-m6lkrehi 340 15 p p NN cord-335975-m6lkrehi 340 16 = = SYM cord-335975-m6lkrehi 340 17 0.58 0.58 CD cord-335975-m6lkrehi 340 18 ) ) -RRB- cord-335975-m6lkrehi 340 19 and and CC cord-335975-m6lkrehi 340 20 no no DT cord-335975-m6lkrehi 340 21 adverse adverse JJ cord-335975-m6lkrehi 340 22 event event NN cord-335975-m6lkrehi 340 23 was be VBD cord-335975-m6lkrehi 340 24 related relate VBN cord-335975-m6lkrehi 340 25 to to TO cord-335975-m6lkrehi 340 26 study study VB cord-335975-m6lkrehi 340 27 treatment treatment NN cord-335975-m6lkrehi 340 28 . . . cord-335975-m6lkrehi 341 1 Conclusion conclusion NN cord-335975-m6lkrehi 341 2 : : : cord-335975-m6lkrehi 341 3 Short short JJ cord-335975-m6lkrehi 341 4 - - HYPH cord-335975-m6lkrehi 341 5 term term NN cord-335975-m6lkrehi 341 6 antibiotic antibiotic JJ cord-335975-m6lkrehi 341 7 prophylaxis prophylaxis NN cord-335975-m6lkrehi 341 8 with with IN cord-335975-m6lkrehi 341 9 amoxicillin amoxicillin NNP cord-335975-m6lkrehi 341 10 - - HYPH cord-335975-m6lkrehi 341 11 clavulanic clavulanic NNP cord-335975-m6lkrehi 341 12 acid acid NN cord-335975-m6lkrehi 341 13 significantly significantly RB cord-335975-m6lkrehi 341 14 decreases decrease VBZ cord-335975-m6lkrehi 341 15 incidence incidence NN cord-335975-m6lkrehi 341 16 of of IN cord-335975-m6lkrehi 341 17 early early JJ cord-335975-m6lkrehi 341 18 VAP VAP NNP cord-335975-m6lkrehi 341 19 in in IN cord-335975-m6lkrehi 341 20 patients patient NNS cord-335975-m6lkrehi 341 21 treated treat VBN cord-335975-m6lkrehi 341 22 with with IN cord-335975-m6lkrehi 341 23 mild mild JJ cord-335975-m6lkrehi 341 24 therapeutic therapeutic JJ cord-335975-m6lkrehi 341 25 hypothermia hypothermia NN cord-335975-m6lkrehi 341 26 after after IN cord-335975-m6lkrehi 341 27 out out NN cord-335975-m6lkrehi 341 28 - - HYPH cord-335975-m6lkrehi 341 29 of of IN cord-335975-m6lkrehi 341 30 - - HYPH cord-335975-m6lkrehi 341 31 hospital hospital NN cord-335975-m6lkrehi 341 32 cardiac cardiac JJ cord-335975-m6lkrehi 341 33 arrest arrest NN cord-335975-m6lkrehi 341 34 related relate VBN cord-335975-m6lkrehi 341 35 to to IN cord-335975-m6lkrehi 341 36 shockable shockable JJ cord-335975-m6lkrehi 341 37 rhythm rhythm NN cord-335975-m6lkrehi 341 38 . . . cord-335975-m6lkrehi 342 1 Introduction introduction NN cord-335975-m6lkrehi 342 2 : : : cord-335975-m6lkrehi 342 3 Immunosuppressed immunosuppressed JJ cord-335975-m6lkrehi 342 4 ( ( -LRB- cord-335975-m6lkrehi 342 5 IS be VBZ cord-335975-m6lkrehi 342 6 ) ) -RRB- cord-335975-m6lkrehi 343 1 patients patient NNS cord-335975-m6lkrehi 343 2 are be VBP cord-335975-m6lkrehi 343 3 prone prone JJ cord-335975-m6lkrehi 343 4 to to TO cord-335975-m6lkrehi 343 5 develop develop VB cord-335975-m6lkrehi 343 6 respiratory respiratory JJ cord-335975-m6lkrehi 343 7 failure failure NN cord-335975-m6lkrehi 343 8 and and CC cord-335975-m6lkrehi 343 9 to to TO cord-335975-m6lkrehi 343 10 need need VB cord-335975-m6lkrehi 343 11 ventilatory ventilatory JJ cord-335975-m6lkrehi 343 12 support support NN cord-335975-m6lkrehi 343 13 . . . cord-335975-m6lkrehi 344 1 Invasive invasive JJ cord-335975-m6lkrehi 344 2 ventilation ventilation NN cord-335975-m6lkrehi 344 3 shared share VBD cord-335975-m6lkrehi 344 4 a a DT cord-335975-m6lkrehi 344 5 grim grim JJ cord-335975-m6lkrehi 344 6 prognosis prognosis NN cord-335975-m6lkrehi 344 7 in in IN cord-335975-m6lkrehi 344 8 the the DT cord-335975-m6lkrehi 344 9 past past JJ cord-335975-m6lkrehi 344 10 and and CC cord-335975-m6lkrehi 344 11 non non JJ cord-335975-m6lkrehi 344 12 - - JJ cord-335975-m6lkrehi 344 13 invasive invasive JJ cord-335975-m6lkrehi 344 14 ventilation ventilation NN cord-335975-m6lkrehi 344 15 had have VBD cord-335975-m6lkrehi 344 16 been be VBN cord-335975-m6lkrehi 344 17 recommended recommend VBN cord-335975-m6lkrehi 344 18 in in IN cord-335975-m6lkrehi 344 19 these these DT cord-335975-m6lkrehi 344 20 patients patient NNS cord-335975-m6lkrehi 344 21 , , , cord-335975-m6lkrehi 344 22 however however RB cord-335975-m6lkrehi 344 23 NIV NIV NNP cord-335975-m6lkrehi 344 24 efficacy efficacy NN cord-335975-m6lkrehi 344 25 has have VBZ cord-335975-m6lkrehi 344 26 been be VBN cord-335975-m6lkrehi 344 27 recently recently RB cord-335975-m6lkrehi 344 28 challenged challenge VBN cord-335975-m6lkrehi 344 29 and and CC cord-335975-m6lkrehi 344 30 the the DT cord-335975-m6lkrehi 344 31 advent advent NN cord-335975-m6lkrehi 344 32 of of IN cord-335975-m6lkrehi 344 33 high high JJ cord-335975-m6lkrehi 344 34 flow flow NN cord-335975-m6lkrehi 344 35 oxygen oxygen NN cord-335975-m6lkrehi 344 36 therapy therapy NN cord-335975-m6lkrehi 344 37 had have VBD cord-335975-m6lkrehi 344 38 brought bring VBN cord-335975-m6lkrehi 344 39 even even RB cord-335975-m6lkrehi 344 40 more more JJR cord-335975-m6lkrehi 344 41 complexity complexity NN cord-335975-m6lkrehi 344 42 in in IN cord-335975-m6lkrehi 344 43 the the DT cord-335975-m6lkrehi 344 44 management management NN cord-335975-m6lkrehi 344 45 of of IN cord-335975-m6lkrehi 344 46 such such JJ cord-335975-m6lkrehi 344 47 patients patient NNS cord-335975-m6lkrehi 344 48 . . . cord-335975-m6lkrehi 345 1 Using use VBG cord-335975-m6lkrehi 345 2 the the DT cord-335975-m6lkrehi 345 3 data datum NNS cord-335975-m6lkrehi 345 4 from from IN cord-335975-m6lkrehi 345 5 a a DT cord-335975-m6lkrehi 345 6 recent recent JJ cord-335975-m6lkrehi 345 7 point point NN cord-335975-m6lkrehi 345 8 - - HYPH cord-335975-m6lkrehi 345 9 prevalence prevalence NN cord-335975-m6lkrehi 345 10 - - HYPH cord-335975-m6lkrehi 345 11 day day NN cord-335975-m6lkrehi 345 12 of of IN cord-335975-m6lkrehi 345 13 hypoxemia hypoxemia NN cord-335975-m6lkrehi 345 14 in in IN cord-335975-m6lkrehi 345 15 ICU ICU NNP cord-335975-m6lkrehi 345 16 , , , cord-335975-m6lkrehi 345 17 we -PRON- PRP cord-335975-m6lkrehi 345 18 compare compare VBP cord-335975-m6lkrehi 345 19 the the DT cord-335975-m6lkrehi 345 20 frequency frequency NN cord-335975-m6lkrehi 345 21 , , , cord-335975-m6lkrehi 345 22 management management NN cord-335975-m6lkrehi 345 23 and and CC cord-335975-m6lkrehi 345 24 outcomes outcome NNS cord-335975-m6lkrehi 345 25 of of IN cord-335975-m6lkrehi 345 26 hypoxemia hypoxemia NN cord-335975-m6lkrehi 345 27 in in IN cord-335975-m6lkrehi 345 28 IS is NN cord-335975-m6lkrehi 345 29 and and CC cord-335975-m6lkrehi 345 30 immuncompetent immuncompetent JJ cord-335975-m6lkrehi 345 31 ( ( -LRB- cord-335975-m6lkrehi 345 32 IC IC NNP cord-335975-m6lkrehi 345 33 ) ) -RRB- cord-335975-m6lkrehi 345 34 patients patient NNS cord-335975-m6lkrehi 345 35 . . . cord-335975-m6lkrehi 346 1 Patients patient NNS cord-335975-m6lkrehi 346 2 and and CC cord-335975-m6lkrehi 346 3 methods method NNS cord-335975-m6lkrehi 346 4 : : : cord-335975-m6lkrehi 346 5 The the DT cord-335975-m6lkrehi 346 6 SPECTRUM SPECTRUM NNP cord-335975-m6lkrehi 346 7 study study NN cord-335975-m6lkrehi 346 8 was be VBD cord-335975-m6lkrehi 346 9 conducted conduct VBN cord-335975-m6lkrehi 346 10 in in IN cord-335975-m6lkrehi 346 11 117 117 CD cord-335975-m6lkrehi 346 12 French French NNP cord-335975-m6lkrehi 346 13 - - HYPH cord-335975-m6lkrehi 346 14 speaking speak VBG cord-335975-m6lkrehi 346 15 ICUs ICUs NNP cord-335975-m6lkrehi 346 16 in in IN cord-335975-m6lkrehi 346 17 7 7 CD cord-335975-m6lkrehi 346 18 countries country NNS cord-335975-m6lkrehi 346 19 during during IN cord-335975-m6lkrehi 346 20 spring spring NN cord-335975-m6lkrehi 346 21 2016 2016 CD cord-335975-m6lkrehi 346 22 . . . cord-335975-m6lkrehi 347 1 IS IS NNP cord-335975-m6lkrehi 347 2 was be VBD cord-335975-m6lkrehi 347 3 retained retain VBN cord-335975-m6lkrehi 347 4 in in IN cord-335975-m6lkrehi 347 5 case case NN cord-335975-m6lkrehi 347 6 of of IN cord-335975-m6lkrehi 347 7 malignant malignant JJ cord-335975-m6lkrehi 347 8 hemopathy hemopathy NNP cord-335975-m6lkrehi 347 9 , , , cord-335975-m6lkrehi 347 10 HIV HIV NNP cord-335975-m6lkrehi 347 11 positivity positivity NN cord-335975-m6lkrehi 347 12 , , , cord-335975-m6lkrehi 347 13 immunosuppressive immunosuppressive JJ cord-335975-m6lkrehi 347 14 drugs drug NNS cord-335975-m6lkrehi 347 15 , , , cord-335975-m6lkrehi 347 16 recent recent JJ cord-335975-m6lkrehi 347 17 chemotherapy chemotherapy NN cord-335975-m6lkrehi 347 18 , , , cord-335975-m6lkrehi 347 19 neutrophil neutrophil NN cord-335975-m6lkrehi 347 20 count count NN cord-335975-m6lkrehi 348 1 < < XX cord-335975-m6lkrehi 348 2 0.5 0.5 CD cord-335975-m6lkrehi 348 3 G G NNP cord-335975-m6lkrehi 348 4 L. L. NNP cord-335975-m6lkrehi 348 5 Hypoxemia Hypoxemia NNP cord-335975-m6lkrehi 348 6 was be VBD cord-335975-m6lkrehi 348 7 defined define VBN cord-335975-m6lkrehi 348 8 as as IN cord-335975-m6lkrehi 348 9 a a DT cord-335975-m6lkrehi 348 10 PaO pao JJ cord-335975-m6lkrehi 348 11 2 2 CD cord-335975-m6lkrehi 348 12 FiO fio NN cord-335975-m6lkrehi 348 13 2 2 CD cord-335975-m6lkrehi 348 14 ratio ratio NN cord-335975-m6lkrehi 348 15 > > XX cord-335975-m6lkrehi 348 16 300 300 CD cord-335975-m6lkrehi 348 17 and and CC cord-335975-m6lkrehi 348 18 separate separate JJ cord-335975-m6lkrehi 348 19 into into IN cord-335975-m6lkrehi 348 20 severe severe JJ cord-335975-m6lkrehi 348 21 ( ( -LRB- cord-335975-m6lkrehi 348 22 > > NFP cord-335975-m6lkrehi 348 23 100 100 CD cord-335975-m6lkrehi 348 24 ) ) -RRB- cord-335975-m6lkrehi 348 25 , , , cord-335975-m6lkrehi 348 26 moderate moderate JJ cord-335975-m6lkrehi 348 27 ( ( -LRB- cord-335975-m6lkrehi 348 28 > > NFP cord-335975-m6lkrehi 348 29 200 200 CD cord-335975-m6lkrehi 348 30 ) ) -RRB- cord-335975-m6lkrehi 348 31 and and CC cord-335975-m6lkrehi 348 32 mild mild JJ cord-335975-m6lkrehi 348 33 ( ( -LRB- cord-335975-m6lkrehi 348 34 > > NFP cord-335975-m6lkrehi 348 35 300 300 CD cord-335975-m6lkrehi 348 36 ) ) -RRB- cord-335975-m6lkrehi 348 37 . . . cord-335975-m6lkrehi 349 1 We -PRON- PRP cord-335975-m6lkrehi 349 2 focused focus VBD cord-335975-m6lkrehi 349 3 on on IN cord-335975-m6lkrehi 349 4 the the DT cord-335975-m6lkrehi 349 5 causes cause NNS cord-335975-m6lkrehi 349 6 of of IN cord-335975-m6lkrehi 349 7 hypoxemia hypoxemia NN cord-335975-m6lkrehi 349 8 , , , cord-335975-m6lkrehi 349 9 the the DT cord-335975-m6lkrehi 349 10 ventilatory ventilatory NN cord-335975-m6lkrehi 349 11 management management NN cord-335975-m6lkrehi 349 12 and and CC cord-335975-m6lkrehi 349 13 the the DT cord-335975-m6lkrehi 349 14 outcome outcome NN cord-335975-m6lkrehi 349 15 . . . cord-335975-m6lkrehi 350 1 Results result NNS cord-335975-m6lkrehi 350 2 : : : cord-335975-m6lkrehi 351 1 Among among IN cord-335975-m6lkrehi 351 2 the the DT cord-335975-m6lkrehi 351 3 1604 1604 CD cord-335975-m6lkrehi 351 4 patients patient NNS cord-335975-m6lkrehi 351 5 included include VBN cord-335975-m6lkrehi 351 6 , , , cord-335975-m6lkrehi 351 7 187 187 CD cord-335975-m6lkrehi 351 8 ( ( -LRB- cord-335975-m6lkrehi 351 9 12 12 CD cord-335975-m6lkrehi 351 10 % % NN cord-335975-m6lkrehi 351 11 ) ) -RRB- cord-335975-m6lkrehi 351 12 were be VBD cord-335975-m6lkrehi 351 13 IS be VBZ cord-335975-m6lkrehi 351 14 out out IN cord-335975-m6lkrehi 351 15 of of IN cord-335975-m6lkrehi 351 16 whom whom WP cord-335975-m6lkrehi 351 17 99 99 CD cord-335975-m6lkrehi 351 18 ( ( -LRB- cord-335975-m6lkrehi 351 19 53 53 CD cord-335975-m6lkrehi 351 20 % % NN cord-335975-m6lkrehi 351 21 ) ) -RRB- cord-335975-m6lkrehi 351 22 were be VBD cord-335975-m6lkrehi 351 23 hypoxemic hypoxemic JJ cord-335975-m6lkrehi 351 24 , , , cord-335975-m6lkrehi 351 25 proportion proportion NN cord-335975-m6lkrehi 351 26 similar similar JJ cord-335975-m6lkrehi 351 27 to to IN cord-335975-m6lkrehi 351 28 the the DT cord-335975-m6lkrehi 351 29 IC IC NNP cord-335975-m6lkrehi 351 30 patients patient NNS cord-335975-m6lkrehi 351 31 . . . cord-335975-m6lkrehi 352 1 Mean mean JJ cord-335975-m6lkrehi 352 2 age age NN cord-335975-m6lkrehi 352 3 and and CC cord-335975-m6lkrehi 352 4 IGS-2 IGS-2 NNP cord-335975-m6lkrehi 352 5 of of IN cord-335975-m6lkrehi 352 6 hypoxemic hypoxemic NNP cord-335975-m6lkrehi 352 7 patients patient NNS cord-335975-m6lkrehi 352 8 were be VBD cord-335975-m6lkrehi 352 9 similar similar JJ cord-335975-m6lkrehi 352 10 in in IN cord-335975-m6lkrehi 352 11 IS is NN cord-335975-m6lkrehi 352 12 and and CC cord-335975-m6lkrehi 352 13 IC IC NNP cord-335975-m6lkrehi 352 14 patients patient NNS cord-335975-m6lkrehi 352 15 . . . cord-335975-m6lkrehi 353 1 Hypoxemia Hypoxemia NNP cord-335975-m6lkrehi 353 2 was be VBD cord-335975-m6lkrehi 353 3 mild mild JJ cord-335975-m6lkrehi 353 4 in in IN cord-335975-m6lkrehi 353 5 46 46 CD cord-335975-m6lkrehi 353 6 ( ( -LRB- cord-335975-m6lkrehi 353 7 46 46 CD cord-335975-m6lkrehi 353 8 % % NN cord-335975-m6lkrehi 353 9 ) ) -RRB- cord-335975-m6lkrehi 353 10 , , , cord-335975-m6lkrehi 353 11 moderate moderate JJ cord-335975-m6lkrehi 353 12 in in IN cord-335975-m6lkrehi 353 13 43 43 CD cord-335975-m6lkrehi 353 14 ( ( -LRB- cord-335975-m6lkrehi 353 15 43 43 CD cord-335975-m6lkrehi 353 16 % % NN cord-335975-m6lkrehi 353 17 ) ) -RRB- cord-335975-m6lkrehi 353 18 and and CC cord-335975-m6lkrehi 353 19 severe severe JJ cord-335975-m6lkrehi 353 20 in in IN cord-335975-m6lkrehi 353 21 10 10 CD cord-335975-m6lkrehi 353 22 ( ( -LRB- cord-335975-m6lkrehi 353 23 10 10 CD cord-335975-m6lkrehi 353 24 % % NN cord-335975-m6lkrehi 353 25 ) ) -RRB- cord-335975-m6lkrehi 354 1 IS be VBZ cord-335975-m6lkrehi 354 2 patients patient NNS cord-335975-m6lkrehi 354 3 with with IN cord-335975-m6lkrehi 354 4 a a DT cord-335975-m6lkrehi 354 5 similar similar JJ cord-335975-m6lkrehi 354 6 distribution distribution NN cord-335975-m6lkrehi 354 7 compared compare VBN cord-335975-m6lkrehi 354 8 to to IN cord-335975-m6lkrehi 354 9 hypoxemic hypoxemic JJ cord-335975-m6lkrehi 354 10 IC IC NNP cord-335975-m6lkrehi 354 11 patients patient NNS cord-335975-m6lkrehi 354 12 . . . cord-335975-m6lkrehi 355 1 The the DT cord-335975-m6lkrehi 355 2 causes cause NNS cord-335975-m6lkrehi 355 3 of of IN cord-335975-m6lkrehi 355 4 hypoxemia hypoxemia NN cord-335975-m6lkrehi 355 5 were be VBD cord-335975-m6lkrehi 355 6 also also RB cord-335975-m6lkrehi 355 7 similar similar JJ cord-335975-m6lkrehi 355 8 pneumonia pneumonia NN cord-335975-m6lkrehi 355 9 being be VBG cord-335975-m6lkrehi 355 10 the the DT cord-335975-m6lkrehi 355 11 leading lead VBG cord-335975-m6lkrehi 355 12 cause cause NN cord-335975-m6lkrehi 355 13 . . . cord-335975-m6lkrehi 356 1 24 24 CD cord-335975-m6lkrehi 356 2 ( ( -LRB- cord-335975-m6lkrehi 356 3 24 24 CD cord-335975-m6lkrehi 356 4 % % NN cord-335975-m6lkrehi 356 5 ) ) -RRB- cord-335975-m6lkrehi 356 6 hypoxemic hypoxemic NN cord-335975-m6lkrehi 356 7 IS be VBZ cord-335975-m6lkrehi 357 1 patients patient NNS cord-335975-m6lkrehi 357 2 fulfilled fulfil VBD cord-335975-m6lkrehi 357 3 the the DT cord-335975-m6lkrehi 357 4 Berlin Berlin NNP cord-335975-m6lkrehi 357 5 criteria criterion NNS cord-335975-m6lkrehi 357 6 for for IN cord-335975-m6lkrehi 357 7 ARDS ARDS NNP cord-335975-m6lkrehi 357 8 in in IN cord-335975-m6lkrehi 357 9 a a DT cord-335975-m6lkrehi 357 10 similar similar JJ cord-335975-m6lkrehi 357 11 proportion proportion NN cord-335975-m6lkrehi 357 12 to to IN cord-335975-m6lkrehi 357 13 IC IC NNP cord-335975-m6lkrehi 357 14 patients patient NNS cord-335975-m6lkrehi 357 15 . . . cord-335975-m6lkrehi 358 1 Respiratory respiratory JJ cord-335975-m6lkrehi 358 2 support support NN cord-335975-m6lkrehi 358 3 used use VBN cord-335975-m6lkrehi 358 4 in in IN cord-335975-m6lkrehi 358 5 hypoxemic hypoxemic NNP cord-335975-m6lkrehi 358 6 IS be VBZ cord-335975-m6lkrehi 358 7 patients patient NNS cord-335975-m6lkrehi 358 8 was be VBD cord-335975-m6lkrehi 358 9 ambient ambient JJ cord-335975-m6lkrehi 358 10 air air NN cord-335975-m6lkrehi 358 11 in in IN cord-335975-m6lkrehi 358 12 3 3 CD cord-335975-m6lkrehi 358 13 , , , cord-335975-m6lkrehi 358 14 low low JJ cord-335975-m6lkrehi 358 15 flow flow NN cord-335975-m6lkrehi 358 16 oxygen oxygen NN cord-335975-m6lkrehi 358 17 in in IN cord-335975-m6lkrehi 358 18 24 24 CD cord-335975-m6lkrehi 358 19 , , , cord-335975-m6lkrehi 358 20 high high JJ cord-335975-m6lkrehi 358 21 flow flow NN cord-335975-m6lkrehi 358 22 in in IN cord-335975-m6lkrehi 358 23 11 11 CD cord-335975-m6lkrehi 358 24 , , , cord-335975-m6lkrehi 358 25 NIV NIV NNP cord-335975-m6lkrehi 358 26 in in IN cord-335975-m6lkrehi 358 27 5 5 CD cord-335975-m6lkrehi 358 28 and and CC cord-335975-m6lkrehi 358 29 invasive invasive JJ cord-335975-m6lkrehi 358 30 ventilation ventilation NN cord-335975-m6lkrehi 358 31 in in IN cord-335975-m6lkrehi 358 32 56 56 CD cord-335975-m6lkrehi 358 33 patients patient NNS cord-335975-m6lkrehi 358 34 , , , cord-335975-m6lkrehi 358 35 with with IN cord-335975-m6lkrehi 358 36 a a DT cord-335975-m6lkrehi 358 37 different different JJ cord-335975-m6lkrehi 358 38 distribution distribution NN cord-335975-m6lkrehi 358 39 from from IN cord-335975-m6lkrehi 358 40 the the DT cord-335975-m6lkrehi 358 41 IC IC NNP cord-335975-m6lkrehi 358 42 patients patient NNS cord-335975-m6lkrehi 358 43 ( ( -LRB- cord-335975-m6lkrehi 358 44 more more JJR cord-335975-m6lkrehi 358 45 patients patient NNS cord-335975-m6lkrehi 358 46 on on IN cord-335975-m6lkrehi 358 47 high high JJ cord-335975-m6lkrehi 358 48 flow flow NN cord-335975-m6lkrehi 358 49 therapy therapy NN cord-335975-m6lkrehi 358 50 and and CC cord-335975-m6lkrehi 358 51 less less RBR cord-335975-m6lkrehi 358 52 invasively invasively RB cord-335975-m6lkrehi 358 53 ventilated ventilate VBN cord-335975-m6lkrehi 358 54 ) ) -RRB- cord-335975-m6lkrehi 358 55 . . . cord-335975-m6lkrehi 359 1 The the DT cord-335975-m6lkrehi 359 2 day day NN cord-335975-m6lkrehi 359 3 of of IN cord-335975-m6lkrehi 359 4 the the DT cord-335975-m6lkrehi 359 5 study study NN cord-335975-m6lkrehi 359 6 , , , cord-335975-m6lkrehi 359 7 thoracic thoracic JJ cord-335975-m6lkrehi 359 8 CT CT NNP cord-335975-m6lkrehi 359 9 scan scan NN cord-335975-m6lkrehi 359 10 and and CC cord-335975-m6lkrehi 359 11 echocardiography echocardiography NN cord-335975-m6lkrehi 359 12 were be VBD cord-335975-m6lkrehi 359 13 performed perform VBN cord-335975-m6lkrehi 359 14 in in IN cord-335975-m6lkrehi 359 15 a a DT cord-335975-m6lkrehi 359 16 similar similar JJ cord-335975-m6lkrehi 359 17 proportion proportion NN cord-335975-m6lkrehi 359 18 in in IN cord-335975-m6lkrehi 359 19 IS is NN cord-335975-m6lkrehi 359 20 and and CC cord-335975-m6lkrehi 359 21 IC IC NNP cord-335975-m6lkrehi 359 22 patients patient NNS cord-335975-m6lkrehi 359 23 whereas whereas IN cord-335975-m6lkrehi 359 24 broncho broncho JJ cord-335975-m6lkrehi 359 25 - - HYPH cord-335975-m6lkrehi 359 26 alveolar alveolar NN cord-335975-m6lkrehi 359 27 lavage lavage NN cord-335975-m6lkrehi 359 28 was be VBD cord-335975-m6lkrehi 359 29 more more RBR cord-335975-m6lkrehi 359 30 frequently frequently RB cord-335975-m6lkrehi 359 31 performed perform VBN cord-335975-m6lkrehi 359 32 in in IN cord-335975-m6lkrehi 359 33 IS be VBZ cord-335975-m6lkrehi 359 34 patients patient NNS cord-335975-m6lkrehi 359 35 ( ( -LRB- cord-335975-m6lkrehi 359 36 14 14 CD cord-335975-m6lkrehi 359 37 vs vs IN cord-335975-m6lkrehi 359 38 6 6 CD cord-335975-m6lkrehi 359 39 % % NN cord-335975-m6lkrehi 359 40 , , , cord-335975-m6lkrehi 359 41 p p NN cord-335975-m6lkrehi 359 42 < < XX cord-335975-m6lkrehi 359 43 0.001 0.001 CD cord-335975-m6lkrehi 359 44 ) ) -RRB- cord-335975-m6lkrehi 359 45 . . . cord-335975-m6lkrehi 360 1 Finally finally RB cord-335975-m6lkrehi 360 2 , , , cord-335975-m6lkrehi 360 3 as as IN cord-335975-m6lkrehi 360 4 expected expect VBN cord-335975-m6lkrehi 360 5 , , , cord-335975-m6lkrehi 360 6 ICU ICU NNP cord-335975-m6lkrehi 360 7 mortality mortality NN cord-335975-m6lkrehi 360 8 was be VBD cord-335975-m6lkrehi 360 9 higher high JJR cord-335975-m6lkrehi 360 10 in in IN cord-335975-m6lkrehi 360 11 hypoxemic hypoxemic NNP cord-335975-m6lkrehi 361 1 IS be VBZ cord-335975-m6lkrehi 361 2 patients patient NNS cord-335975-m6lkrehi 361 3 ( ( -LRB- cord-335975-m6lkrehi 361 4 38 38 CD cord-335975-m6lkrehi 361 5 vs vs IN cord-335975-m6lkrehi 361 6 25 25 CD cord-335975-m6lkrehi 361 7 % % NN cord-335975-m6lkrehi 361 8 , , , cord-335975-m6lkrehi 361 9 p p NN cord-335975-m6lkrehi 361 10 < < XX cord-335975-m6lkrehi 361 11 0.01 0.01 CD cord-335975-m6lkrehi 361 12 ) ) -RRB- cord-335975-m6lkrehi 361 13 . . . cord-335975-m6lkrehi 362 1 Conclusion conclusion NN cord-335975-m6lkrehi 362 2 : : : cord-335975-m6lkrehi 363 1 Immunosuppression Immunosuppression NNP cord-335975-m6lkrehi 363 2 in in IN cord-335975-m6lkrehi 363 3 the the DT cord-335975-m6lkrehi 363 4 ICU ICU NNP cord-335975-m6lkrehi 363 5 seems seem VBZ cord-335975-m6lkrehi 363 6 not not RB cord-335975-m6lkrehi 363 7 to to TO cord-335975-m6lkrehi 363 8 be be VB cord-335975-m6lkrehi 363 9 associated associate VBN cord-335975-m6lkrehi 363 10 with with IN cord-335975-m6lkrehi 363 11 hypoxemia hypoxemia NN cord-335975-m6lkrehi 363 12 , , , cord-335975-m6lkrehi 363 13 severity severity NN cord-335975-m6lkrehi 363 14 of of IN cord-335975-m6lkrehi 363 15 hypoxemia hypoxemia NN cord-335975-m6lkrehi 363 16 or or CC cord-335975-m6lkrehi 363 17 ARDS ARDS NNP cord-335975-m6lkrehi 363 18 . . . cord-335975-m6lkrehi 364 1 Oxygenation oxygenation NN cord-335975-m6lkrehi 364 2 management management NN cord-335975-m6lkrehi 364 3 is be VBZ cord-335975-m6lkrehi 364 4 slightly slightly RB cord-335975-m6lkrehi 364 5 different different JJ cord-335975-m6lkrehi 364 6 from from IN cord-335975-m6lkrehi 364 7 immunocompetent immunocompetent JJ cord-335975-m6lkrehi 364 8 patients patient NNS cord-335975-m6lkrehi 364 9 with with IN cord-335975-m6lkrehi 364 10 more more RBR cord-335975-m6lkrehi 364 11 frequent frequent JJ cord-335975-m6lkrehi 364 12 use use NN cord-335975-m6lkrehi 364 13 of of IN cord-335975-m6lkrehi 364 14 high high JJ cord-335975-m6lkrehi 364 15 flow flow NN cord-335975-m6lkrehi 364 16 therapy therapy NN cord-335975-m6lkrehi 364 17 . . . cord-335975-m6lkrehi 365 1 59 59 CD cord-335975-m6lkrehi 366 1 ( ( -LRB- cord-335975-m6lkrehi 366 2 13 13 CD cord-335975-m6lkrehi 366 3 ) ) -RRB- cord-335975-m6lkrehi 366 4 mmHg mmHg NNS cord-335975-m6lkrehi 366 5 , , , cord-335975-m6lkrehi 366 6 pH pH NNP cord-335975-m6lkrehi 366 7 7.26 7.26 CD cord-335975-m6lkrehi 366 8 ( ( -LRB- cord-335975-m6lkrehi 366 9 0.1 0.1 CD cord-335975-m6lkrehi 366 10 ) ) -RRB- cord-335975-m6lkrehi 366 11 . . . cord-335975-m6lkrehi 367 1 142 142 CD cord-335975-m6lkrehi 367 2 were be VBD cord-335975-m6lkrehi 367 3 included include VBN cord-335975-m6lkrehi 367 4 in in IN cord-335975-m6lkrehi 367 5 the the DT cord-335975-m6lkrehi 367 6 2 2 CD cord-335975-m6lkrehi 367 7 L l NN cord-335975-m6lkrehi 367 8 / / SYM cord-335975-m6lkrehi 367 9 kg kg NNP cord-335975-m6lkrehi 367 10 / / SYM cord-335975-m6lkrehi 367 11 min min NNP cord-335975-m6lkrehi 367 12 group group NN cord-335975-m6lkrehi 367 13 and and CC cord-335975-m6lkrehi 367 14 145 145 CD cord-335975-m6lkrehi 367 15 in in IN cord-335975-m6lkrehi 367 16 the the DT cord-335975-m6lkrehi 367 17 3 3 CD cord-335975-m6lkrehi 367 18 L l NN cord-335975-m6lkrehi 367 19 / / SYM cord-335975-m6lkrehi 367 20 kg kg NNP cord-335975-m6lkrehi 367 21 / / SYM cord-335975-m6lkrehi 367 22 min min NNP cord-335975-m6lkrehi 367 23 group group NN cord-335975-m6lkrehi 367 24 . . . cord-335975-m6lkrehi 368 1 No no DT cord-335975-m6lkrehi 368 2 difference difference NN cord-335975-m6lkrehi 368 3 was be VBD cord-335975-m6lkrehi 368 4 observed observe VBN cord-335975-m6lkrehi 368 5 between between IN cord-335975-m6lkrehi 368 6 groups group NNS cord-335975-m6lkrehi 368 7 for for IN cord-335975-m6lkrehi 368 8 baseline baseline JJ cord-335975-m6lkrehi 368 9 characteristics characteristic NNS cord-335975-m6lkrehi 368 10 . . . cord-335975-m6lkrehi 369 1 Failure failure NN cord-335975-m6lkrehi 369 2 rate rate NN cord-335975-m6lkrehi 369 3 was be VBD cord-335975-m6lkrehi 369 4 not not RB cord-335975-m6lkrehi 369 5 different different JJ cord-335975-m6lkrehi 369 6 between between IN cord-335975-m6lkrehi 370 1 groups-38.7 groups-38.7 NNP cord-335975-m6lkrehi 370 2 vs vs IN cord-335975-m6lkrehi 370 3 39.3 39.3 CD cord-335975-m6lkrehi 370 4 % % NN cord-335975-m6lkrehi 370 5 + + CC cord-335975-m6lkrehi 370 6 p p NN cord-335975-m6lkrehi 370 7 = = SYM cord-335975-m6lkrehi 370 8 0.92 0.92 CD cord-335975-m6lkrehi 370 9 . . . cord-335975-m6lkrehi 371 1 No no DT cord-335975-m6lkrehi 371 2 center center NN cord-335975-m6lkrehi 371 3 effect effect NN cord-335975-m6lkrehi 371 4 was be VBD cord-335975-m6lkrehi 371 5 observed observe VBN cord-335975-m6lkrehi 371 6 for for IN cord-335975-m6lkrehi 371 7 failure failure NN cord-335975-m6lkrehi 371 8 . . . cord-335975-m6lkrehi 372 1 Discomfort discomfort NN cord-335975-m6lkrehi 372 2 was be VBD cord-335975-m6lkrehi 372 3 more more RBR cord-335975-m6lkrehi 372 4 frequent frequent JJ cord-335975-m6lkrehi 372 5 in in IN cord-335975-m6lkrehi 372 6 the the DT cord-335975-m6lkrehi 372 7 3 3 CD cord-335975-m6lkrehi 372 8 L l NN cord-335975-m6lkrehi 372 9 kg kg NNP cord-335975-m6lkrehi 372 10 min min NN cord-335975-m6lkrehi 372 11 group-7 group-7 NNP cord-335975-m6lkrehi 372 12 vs vs IN cord-335975-m6lkrehi 372 13 17 17 CD cord-335975-m6lkrehi 372 14 % % NN cord-335975-m6lkrehi 372 15 + + CC cord-335975-m6lkrehi 372 16 p p NN cord-335975-m6lkrehi 372 17 = = SYM cord-335975-m6lkrehi 372 18 0.006 0.006 CD cord-335975-m6lkrehi 372 19 . . . cord-335975-m6lkrehi 373 1 The the DT cord-335975-m6lkrehi 373 2 length length NN cord-335975-m6lkrehi 373 3 of of IN cord-335975-m6lkrehi 373 4 stay stay NN cord-335975-m6lkrehi 373 5 was be VBD cord-335975-m6lkrehi 373 6 shorter short JJR cord-335975-m6lkrehi 373 7 in in IN cord-335975-m6lkrehi 373 8 the the DT cord-335975-m6lkrehi 373 9 2 2 CD cord-335975-m6lkrehi 373 10 L l NN cord-335975-m6lkrehi 373 11 kg kg NN cord-335975-m6lkrehi 373 12 min min NN cord-335975-m6lkrehi 373 13 group-5.3 group-5.3 NNP cord-335975-m6lkrehi 373 14 ( ( -LRB- cord-335975-m6lkrehi 373 15 2.8 2.8 CD cord-335975-m6lkrehi 373 16 ) ) -RRB- cord-335975-m6lkrehi 373 17 vs vs IN cord-335975-m6lkrehi 373 18 6.4 6.4 CD cord-335975-m6lkrehi 373 19 ( ( -LRB- cord-335975-m6lkrehi 373 20 5 5 CD cord-335975-m6lkrehi 373 21 ) ) -RRB- cord-335975-m6lkrehi 373 22 days day NNS cord-335975-m6lkrehi 374 1 + + CC cord-335975-m6lkrehi 375 1 p p NN cord-335975-m6lkrehi 375 2 = = SYM cord-335975-m6lkrehi 375 3 0.048 0.048 CD cord-335975-m6lkrehi 375 4 . . . cord-335975-m6lkrehi 376 1 Intubation intubation NN cord-335975-m6lkrehi 376 2 occurred occur VBD cord-335975-m6lkrehi 376 3 in in IN cord-335975-m6lkrehi 376 4 4 4 CD cord-335975-m6lkrehi 376 5 142 142 CD cord-335975-m6lkrehi 376 6 patients patient NNS cord-335975-m6lkrehi 376 7 in in IN cord-335975-m6lkrehi 376 8 the the DT cord-335975-m6lkrehi 376 9 2 2 CD cord-335975-m6lkrehi 376 10 L l NN cord-335975-m6lkrehi 376 11 / / SYM cord-335975-m6lkrehi 376 12 kg kg NNP cord-335975-m6lkrehi 376 13 / / SYM cord-335975-m6lkrehi 376 14 min min NNP cord-335975-m6lkrehi 376 15 group group NN cord-335975-m6lkrehi 376 16 vs vs IN cord-335975-m6lkrehi 376 17 10 10 CD cord-335975-m6lkrehi 376 18 145 145 CD cord-335975-m6lkrehi 376 19 patients patient NNS cord-335975-m6lkrehi 376 20 in in IN cord-335975-m6lkrehi 376 21 the the DT cord-335975-m6lkrehi 376 22 3 3 CD cord-335975-m6lkrehi 376 23 L L NNP cord-335975-m6lkrehi 376 24 kg kg NNP cord-335975-m6lkrehi 376 25 min min NN cord-335975-m6lkrehi 376 26 group group NN cord-335975-m6lkrehi 376 27 ( ( -LRB- cord-335975-m6lkrehi 376 28 p p NN cord-335975-m6lkrehi 376 29 = = SYM cord-335975-m6lkrehi 376 30 0.12 0.12 CD cord-335975-m6lkrehi 376 31 ) ) -RRB- cord-335975-m6lkrehi 376 32 . . . cord-335975-m6lkrehi 377 1 Conclusion conclusion NN cord-335975-m6lkrehi 377 2 : : : cord-335975-m6lkrehi 378 1 HFNC HFNC NNP cord-335975-m6lkrehi 378 2 with with IN cord-335975-m6lkrehi 378 3 a a DT cord-335975-m6lkrehi 378 4 flow flow NN cord-335975-m6lkrehi 378 5 rate rate NN cord-335975-m6lkrehi 378 6 of of IN cord-335975-m6lkrehi 378 7 3 3 CD cord-335975-m6lkrehi 378 8 L l NN cord-335975-m6lkrehi 378 9 / / SYM cord-335975-m6lkrehi 378 10 kg kg NNP cord-335975-m6lkrehi 378 11 / / SYM cord-335975-m6lkrehi 378 12 min min NNP cord-335975-m6lkrehi 378 13 did do VBD cord-335975-m6lkrehi 378 14 not not RB cord-335975-m6lkrehi 378 15 reduce reduce VB cord-335975-m6lkrehi 378 16 the the DT cord-335975-m6lkrehi 378 17 risk risk NN cord-335975-m6lkrehi 378 18 of of IN cord-335975-m6lkrehi 378 19 failure failure NN cord-335975-m6lkrehi 378 20 compared compare VBN cord-335975-m6lkrehi 378 21 to to IN cord-335975-m6lkrehi 378 22 2 2 CD cord-335975-m6lkrehi 378 23 L l NN cord-335975-m6lkrehi 378 24 / / SYM cord-335975-m6lkrehi 378 25 kg kg NNP cord-335975-m6lkrehi 378 26 / / SYM cord-335975-m6lkrehi 378 27 min min NN cord-335975-m6lkrehi 378 28 at at IN cord-335975-m6lkrehi 378 29 the the DT cord-335975-m6lkrehi 378 30 initial initial JJ cord-335975-m6lkrehi 378 31 respiratory respiratory JJ cord-335975-m6lkrehi 378 32 management management NN cord-335975-m6lkrehi 378 33 of of IN cord-335975-m6lkrehi 378 34 AVB AVB NNP cord-335975-m6lkrehi 378 35 in in IN cord-335975-m6lkrehi 378 36 young young JJ cord-335975-m6lkrehi 378 37 infants infant NNS cord-335975-m6lkrehi 378 38 . . . cord-335975-m6lkrehi 379 1 Comparison comparison NN cord-335975-m6lkrehi 379 2 of of IN cord-335975-m6lkrehi 379 3 epinephrine epinephrine NN cord-335975-m6lkrehi 379 4 and and CC cord-335975-m6lkrehi 379 5 norepinephrine norepinephrine NN cord-335975-m6lkrehi 379 6 for for IN cord-335975-m6lkrehi 379 7 the the DT cord-335975-m6lkrehi 379 8 treatment treatment NN cord-335975-m6lkrehi 379 9 of of IN cord-335975-m6lkrehi 379 10 cardiogenic cardiogenic JJ cord-335975-m6lkrehi 379 11 shock shock NN cord-335975-m6lkrehi 379 12 following follow VBG cord-335975-m6lkrehi 379 13 acute acute JJ cord-335975-m6lkrehi 379 14 myocardial myocardial JJ cord-335975-m6lkrehi 379 15 infarction infarction NN cord-335975-m6lkrehi 379 16 . . . cord-335975-m6lkrehi 380 1 OPTIMA OPTIMA NNP cord-335975-m6lkrehi 380 2 CC CC NNP cord-335975-m6lkrehi 380 3 study study NN cord-335975-m6lkrehi 380 4 Levy Levy NNP cord-335975-m6lkrehi 380 5 Bruno Bruno NNP cord-335975-m6lkrehi 380 6 1 1 CD cord-335975-m6lkrehi 380 7 Introduction introduction NN cord-335975-m6lkrehi 380 8 : : : cord-335975-m6lkrehi 381 1 Despite despite IN cord-335975-m6lkrehi 381 2 the the DT cord-335975-m6lkrehi 381 3 frequent frequent JJ cord-335975-m6lkrehi 381 4 use use NN cord-335975-m6lkrehi 381 5 of of IN cord-335975-m6lkrehi 381 6 vasopressors vasopressor NNS cord-335975-m6lkrehi 381 7 which which WDT cord-335975-m6lkrehi 381 8 are be VBP cord-335975-m6lkrehi 381 9 administered administer VBN cord-335975-m6lkrehi 381 10 in in IN cord-335975-m6lkrehi 381 11 90 90 CD cord-335975-m6lkrehi 381 12 % % NN cord-335975-m6lkrehi 381 13 of of IN cord-335975-m6lkrehi 381 14 patients patient NNS cord-335975-m6lkrehi 381 15 in in IN cord-335975-m6lkrehi 381 16 cardiogenic cardiogenic JJ cord-335975-m6lkrehi 381 17 shock shock NN cord-335975-m6lkrehi 381 18 ( ( -LRB- cord-335975-m6lkrehi 381 19 CS CS NNP cord-335975-m6lkrehi 381 20 ) ) -RRB- cord-335975-m6lkrehi 381 21 , , , cord-335975-m6lkrehi 381 22 there there EX cord-335975-m6lkrehi 381 23 is be VBZ cord-335975-m6lkrehi 381 24 only only RB cord-335975-m6lkrehi 381 25 limited limited JJ cord-335975-m6lkrehi 381 26 evidence evidence NN cord-335975-m6lkrehi 381 27 from from IN cord-335975-m6lkrehi 381 28 randomized randomized JJ cord-335975-m6lkrehi 381 29 trials trial NNS cord-335975-m6lkrehi 381 30 comparing compare VBG cord-335975-m6lkrehi 381 31 vasopressor vasopressor NN cord-335975-m6lkrehi 381 32 in in IN cord-335975-m6lkrehi 381 33 CS CS NNP cord-335975-m6lkrehi 381 34 . . . cord-335975-m6lkrehi 382 1 Hence hence RB cord-335975-m6lkrehi 382 2 , , , cord-335975-m6lkrehi 382 3 the the DT cord-335975-m6lkrehi 382 4 OPTIMA OPTIMA NNP cord-335975-m6lkrehi 382 5 CC CC NNP cord-335975-m6lkrehi 382 6 study study NN cord-335975-m6lkrehi 382 7 was be VBD cord-335975-m6lkrehi 382 8 designed design VBN cord-335975-m6lkrehi 382 9 to to TO cord-335975-m6lkrehi 382 10 compare compare VB cord-335975-m6lkrehi 382 11 epinephrine epinephrine NN cord-335975-m6lkrehi 382 12 and and CC cord-335975-m6lkrehi 382 13 norepinephrine norepinephrine NN cord-335975-m6lkrehi 382 14 in in IN cord-335975-m6lkrehi 382 15 cardiogenic cardiogenic JJ cord-335975-m6lkrehi 382 16 shock shock NN cord-335975-m6lkrehi 382 17 following follow VBG cord-335975-m6lkrehi 382 18 myocardial myocardial JJ cord-335975-m6lkrehi 382 19 infarction infarction NN cord-335975-m6lkrehi 382 20 . . . cord-335975-m6lkrehi 383 1 Patients patient NNS cord-335975-m6lkrehi 383 2 and and CC cord-335975-m6lkrehi 383 3 methods method NNS cord-335975-m6lkrehi 383 4 : : : cord-335975-m6lkrehi 383 5 Multicenter multicenter JJ cord-335975-m6lkrehi 383 6 , , , cord-335975-m6lkrehi 383 7 double double JJ cord-335975-m6lkrehi 383 8 - - HYPH cord-335975-m6lkrehi 383 9 blind blind JJ cord-335975-m6lkrehi 383 10 , , , cord-335975-m6lkrehi 383 11 randomized randomized JJ cord-335975-m6lkrehi 383 12 trial trial NN cord-335975-m6lkrehi 383 13 in in IN cord-335975-m6lkrehi 383 14 8 8 CD cord-335975-m6lkrehi 383 15 french french JJ cord-335975-m6lkrehi 383 16 ICU ICU NNP cord-335975-m6lkrehi 383 17 . . . cord-335975-m6lkrehi 384 1 Cardiogenic cardiogenic JJ cord-335975-m6lkrehi 384 2 shock shock NN cord-335975-m6lkrehi 384 3 patients patient NNS cord-335975-m6lkrehi 384 4 due due JJ cord-335975-m6lkrehi 384 5 to to IN cord-335975-m6lkrehi 384 6 myocardial myocardial JJ cord-335975-m6lkrehi 384 7 infarction infarction NN cord-335975-m6lkrehi 384 8 treated treat VBN cord-335975-m6lkrehi 384 9 by by IN cord-335975-m6lkrehi 384 10 PCI PCI NNP cord-335975-m6lkrehi 384 11 were be VBD cord-335975-m6lkrehi 384 12 randomized randomize VBN cord-335975-m6lkrehi 384 13 to to TO cord-335975-m6lkrehi 384 14 receive receive VB cord-335975-m6lkrehi 384 15 epinephrine epinephrine NN cord-335975-m6lkrehi 384 16 or or CC cord-335975-m6lkrehi 384 17 norepinephrine norepinephrine NN cord-335975-m6lkrehi 384 18 to to TO cord-335975-m6lkrehi 384 19 maintain maintain VB cord-335975-m6lkrehi 384 20 MAP map NN cord-335975-m6lkrehi 384 21 at at IN cord-335975-m6lkrehi 384 22 70 70 CD cord-335975-m6lkrehi 384 23 mmHg mmHg NNS cord-335975-m6lkrehi 384 24 . . . cord-335975-m6lkrehi 385 1 Dobutamine Dobutamine NNP cord-335975-m6lkrehi 385 2 was be VBD cord-335975-m6lkrehi 385 3 introduced introduce VBN cord-335975-m6lkrehi 385 4 at at IN cord-335975-m6lkrehi 385 5 the the DT cord-335975-m6lkrehi 385 6 physician physician NN cord-335975-m6lkrehi 385 7 discretion discretion NN cord-335975-m6lkrehi 385 8 according accord VBG cord-335975-m6lkrehi 385 9 to to IN cord-335975-m6lkrehi 385 10 a a DT cord-335975-m6lkrehi 385 11 combination combination NN cord-335975-m6lkrehi 385 12 of of IN cord-335975-m6lkrehi 385 13 parameters parameter NNS cord-335975-m6lkrehi 385 14 - - HYPH cord-335975-m6lkrehi 385 15 echocardiographic echocardiographic JJ cord-335975-m6lkrehi 385 16 parameters parameter NNS cord-335975-m6lkrehi 385 17 , , , cord-335975-m6lkrehi 385 18 cardiac cardiac JJ cord-335975-m6lkrehi 385 19 index index NN cord-335975-m6lkrehi 385 20 , , , cord-335975-m6lkrehi 385 21 lactate lactate NN cord-335975-m6lkrehi 385 22 clearance clearance NN cord-335975-m6lkrehi 385 23 , , , cord-335975-m6lkrehi 385 24 SVO2 SVO2 NNP cord-335975-m6lkrehi 385 25 and and CC cord-335975-m6lkrehi 385 26 Swan Swan NNP cord-335975-m6lkrehi 385 27 - - HYPH cord-335975-m6lkrehi 385 28 Ganz Ganz NNP cord-335975-m6lkrehi 385 29 derived derive VBN cord-335975-m6lkrehi 385 30 parameters parameter NNS cord-335975-m6lkrehi 385 31 . . . cord-335975-m6lkrehi 386 1 Results result NNS cord-335975-m6lkrehi 386 2 : : : cord-335975-m6lkrehi 387 1 56/57 56/57 CD cord-335975-m6lkrehi 387 2 patients patient NNS cord-335975-m6lkrehi 387 3 were be VBD cord-335975-m6lkrehi 387 4 ventilated ventilate VBN cord-335975-m6lkrehi 387 5 ( ( -LRB- cord-335975-m6lkrehi 387 6 98 98 CD cord-335975-m6lkrehi 387 7 % % NN cord-335975-m6lkrehi 387 8 ) ) -RRB- cord-335975-m6lkrehi 387 9 . . . cord-335975-m6lkrehi 388 1 There there EX cord-335975-m6lkrehi 388 2 were be VBD cord-335975-m6lkrehi 388 3 no no DT cord-335975-m6lkrehi 388 4 differences difference NNS cord-335975-m6lkrehi 388 5 in in IN cord-335975-m6lkrehi 388 6 the the DT cord-335975-m6lkrehi 388 7 duration duration NN cord-335975-m6lkrehi 388 8 nor nor CC cord-335975-m6lkrehi 388 9 in in IN cord-335975-m6lkrehi 388 10 the the DT cord-335975-m6lkrehi 388 11 maximal maximal JJ cord-335975-m6lkrehi 388 12 dose dose NN cord-335975-m6lkrehi 388 13 or or CC cord-335975-m6lkrehi 388 14 cumulated cumulated JJ cord-335975-m6lkrehi 388 15 dose dose NN cord-335975-m6lkrehi 388 16 of of IN cord-335975-m6lkrehi 388 17 epinephrine epinephrine NN cord-335975-m6lkrehi 388 18 or or CC cord-335975-m6lkrehi 388 19 norepinephrine norepinephrine NN cord-335975-m6lkrehi 388 20 . . . cord-335975-m6lkrehi 389 1 Dobutamine Dobutamine NNP cord-335975-m6lkrehi 389 2 was be VBD cord-335975-m6lkrehi 389 3 used use VBN cord-335975-m6lkrehi 389 4 in in IN cord-335975-m6lkrehi 389 5 18/27 18/27 CD cord-335975-m6lkrehi 389 6 ( ( -LRB- cord-335975-m6lkrehi 389 7 67 67 CD cord-335975-m6lkrehi 389 8 % % NN cord-335975-m6lkrehi 389 9 ) ) -RRB- cord-335975-m6lkrehi 389 10 in in IN cord-335975-m6lkrehi 389 11 the the DT cord-335975-m6lkrehi 389 12 epinephrine epinephrine NN cord-335975-m6lkrehi 389 13 group group NN cord-335975-m6lkrehi 389 14 and and CC cord-335975-m6lkrehi 389 15 in in IN cord-335975-m6lkrehi 389 16 20/30 20/30 CD cord-335975-m6lkrehi 389 17 ( ( -LRB- cord-335975-m6lkrehi 389 18 67 67 CD cord-335975-m6lkrehi 389 19 % % NN cord-335975-m6lkrehi 389 20 ) ) -RRB- cord-335975-m6lkrehi 389 21 in in IN cord-335975-m6lkrehi 389 22 the the DT cord-335975-m6lkrehi 389 23 norepinephrine norepinephrine NN cord-335975-m6lkrehi 389 24 group group NN cord-335975-m6lkrehi 389 25 . . . cord-335975-m6lkrehi 390 1 There there EX cord-335975-m6lkrehi 390 2 were be VBD cord-335975-m6lkrehi 390 3 no no DT cord-335975-m6lkrehi 390 4 differences difference NNS cord-335975-m6lkrehi 390 5 in in IN cord-335975-m6lkrehi 390 6 the the DT cord-335975-m6lkrehi 390 7 duration duration NN cord-335975-m6lkrehi 390 8 , , , cord-335975-m6lkrehi 390 9 in in IN cord-335975-m6lkrehi 390 10 the the DT cord-335975-m6lkrehi 390 11 maximal maximal JJ cord-335975-m6lkrehi 390 12 or or CC cord-335975-m6lkrehi 390 13 cumulated cumulated JJ cord-335975-m6lkrehi 390 14 dose dose NN cord-335975-m6lkrehi 390 15 . . . cord-335975-m6lkrehi 391 1 Arterial arterial JJ cord-335975-m6lkrehi 391 2 pressure pressure NN cord-335975-m6lkrehi 391 3 evolution evolution NN cord-335975-m6lkrehi 391 4 was be VBD cord-335975-m6lkrehi 391 5 similar similar JJ cord-335975-m6lkrehi 391 6 . . . cord-335975-m6lkrehi 392 1 Heart heart NN cord-335975-m6lkrehi 392 2 rate rate NN cord-335975-m6lkrehi 392 3 increased increase VBD cord-335975-m6lkrehi 392 4 significantly significantly RB cord-335975-m6lkrehi 392 5 in in IN cord-335975-m6lkrehi 392 6 epinephrine epinephrine NN cord-335975-m6lkrehi 392 7 group group NN cord-335975-m6lkrehi 392 8 and and CC cord-335975-m6lkrehi 392 9 did do VBD cord-335975-m6lkrehi 392 10 not not RB cord-335975-m6lkrehi 392 11 change change VB cord-335975-m6lkrehi 392 12 in in IN cord-335975-m6lkrehi 392 13 norepinephrine norepinephrine NN cord-335975-m6lkrehi 392 14 group group NN cord-335975-m6lkrehi 392 15 . . . cord-335975-m6lkrehi 393 1 Cardiac cardiac JJ cord-335975-m6lkrehi 393 2 index index NN cord-335975-m6lkrehi 393 3 and and CC cord-335975-m6lkrehi 393 4 cardiac cardiac JJ cord-335975-m6lkrehi 393 5 power power NN cord-335975-m6lkrehi 393 6 index index NN cord-335975-m6lkrehi 393 7 increased increase VBD cord-335975-m6lkrehi 393 8 significantly significantly RB cord-335975-m6lkrehi 393 9 more more RBR cord-335975-m6lkrehi 393 10 in in IN cord-335975-m6lkrehi 393 11 the the DT cord-335975-m6lkrehi 393 12 epinephrine epinephrine NN cord-335975-m6lkrehi 393 13 group group NN cord-335975-m6lkrehi 393 14 than than IN cord-335975-m6lkrehi 393 15 in in IN cord-335975-m6lkrehi 393 16 the the DT cord-335975-m6lkrehi 393 17 norepinephrine norepinephrine NN cord-335975-m6lkrehi 393 18 group group NN cord-335975-m6lkrehi 393 19 . . . cord-335975-m6lkrehi 394 1 Cardiac cardiac JJ cord-335975-m6lkrehi 394 2 double double JJ cord-335975-m6lkrehi 394 3 product product NN cord-335975-m6lkrehi 394 4 , , , cord-335975-m6lkrehi 394 5 a a DT cord-335975-m6lkrehi 394 6 surrogate surrogate NN cord-335975-m6lkrehi 394 7 of of IN cord-335975-m6lkrehi 394 8 myocardial myocardial JJ cord-335975-m6lkrehi 394 9 oxygen oxygen NN cord-335975-m6lkrehi 394 10 consumption consumption NN cord-335975-m6lkrehi 394 11 increased increase VBN cord-335975-m6lkrehi 394 12 in in IN cord-335975-m6lkrehi 394 13 epinephrine epinephrine NN cord-335975-m6lkrehi 394 14 group group NN cord-335975-m6lkrehi 394 15 and and CC cord-335975-m6lkrehi 394 16 did do VBD cord-335975-m6lkrehi 394 17 not not RB cord-335975-m6lkrehi 394 18 change change VB cord-335975-m6lkrehi 394 19 in in IN cord-335975-m6lkrehi 394 20 norepinephrine norepinephrine NN cord-335975-m6lkrehi 394 21 group group NN cord-335975-m6lkrehi 394 22 . . . cord-335975-m6lkrehi 395 1 Epinephrine epinephrine NN cord-335975-m6lkrehi 395 2 use use NN cord-335975-m6lkrehi 395 3 was be VBD cord-335975-m6lkrehi 395 4 associated associate VBN cord-335975-m6lkrehi 395 5 with with IN cord-335975-m6lkrehi 395 6 a a DT cord-335975-m6lkrehi 395 7 lactic lactic JJ cord-335975-m6lkrehi 395 8 acidosis acidosis NN cord-335975-m6lkrehi 395 9 from from IN cord-335975-m6lkrehi 395 10 H2 H2 NNP cord-335975-m6lkrehi 395 11 to to IN cord-335975-m6lkrehi 395 12 H24 H24 NNP cord-335975-m6lkrehi 395 13 while while IN cord-335975-m6lkrehi 395 14 arterial arterial JJ cord-335975-m6lkrehi 395 15 pH pH NNP cord-335975-m6lkrehi 395 16 increased increase VBD cord-335975-m6lkrehi 395 17 and and CC cord-335975-m6lkrehi 395 18 lactate lactate NN cord-335975-m6lkrehi 395 19 level level NN cord-335975-m6lkrehi 395 20 decreased decrease VBD cord-335975-m6lkrehi 395 21 in in IN cord-335975-m6lkrehi 395 22 norepinephrine norepinephrine NN cord-335975-m6lkrehi 395 23 groupEpinephrine groupepinephrine NN cord-335975-m6lkrehi 395 24 was be VBD cord-335975-m6lkrehi 395 25 significantly significantly RB cord-335975-m6lkrehi 395 26 associated associate VBN cord-335975-m6lkrehi 395 27 with with IN cord-335975-m6lkrehi 395 28 an an DT cord-335975-m6lkrehi 395 29 higher high JJR cord-335975-m6lkrehi 395 30 incidence incidence NN cord-335975-m6lkrehi 395 31 of of IN cord-335975-m6lkrehi 395 32 refractory refractory JJ cord-335975-m6lkrehi 395 33 shock-10/27 shock-10/27 NN cord-335975-m6lkrehi 395 34 ( ( -LRB- cord-335975-m6lkrehi 395 35 37 37 CD cord-335975-m6lkrehi 395 36 % % NN cord-335975-m6lkrehi 395 37 ) ) -RRB- cord-335975-m6lkrehi 395 38 versus versus IN cord-335975-m6lkrehi 395 39 2/30 2/30 CD cord-335975-m6lkrehi 395 40 ( ( -LRB- cord-335975-m6lkrehi 395 41 7 7 CD cord-335975-m6lkrehi 395 42 % % NN cord-335975-m6lkrehi 395 43 ) ) -RRB- cord-335975-m6lkrehi 396 1 p p NN cord-335975-m6lkrehi 396 2 = = SYM cord-335975-m6lkrehi 396 3 0.008 0.008 CD cord-335975-m6lkrehi 396 4 ) ) -RRB- cord-335975-m6lkrehi 396 5 . . . cord-335975-m6lkrehi 397 1 The the DT cord-335975-m6lkrehi 397 2 incidence incidence NN cord-335975-m6lkrehi 397 3 of of IN cord-335975-m6lkrehi 397 4 arrhythmia arrhythmia NN cord-335975-m6lkrehi 397 5 was be VBD cord-335975-m6lkrehi 397 6 identical identical JJ cord-335975-m6lkrehi 397 7 ( ( -LRB- cord-335975-m6lkrehi 397 8 epinephrine-41 epinephrine-41 CD cord-335975-m6lkrehi 397 9 % % NN cord-335975-m6lkrehi 397 10 versus versus IN cord-335975-m6lkrehi 397 11 norepinephrine-33 norepinephrine-33 NNP cord-335975-m6lkrehi 397 12 % % NN cord-335975-m6lkrehi 397 13 , , , cord-335975-m6lkrehi 397 14 p p NN cord-335975-m6lkrehi 397 15 = = SYM cord-335975-m6lkrehi 397 16 0.59 0.59 CD cord-335975-m6lkrehi 397 17 ) ) -RRB- cord-335975-m6lkrehi 397 18 . . . cord-335975-m6lkrehi 398 1 ECMO ECMO NNP cord-335975-m6lkrehi 398 2 was be VBD cord-335975-m6lkrehi 398 3 used use VBN cord-335975-m6lkrehi 398 4 in in IN cord-335975-m6lkrehi 398 5 3/27 3/27 CD cord-335975-m6lkrehi 398 6 ( ( -LRB- cord-335975-m6lkrehi 398 7 11 11 CD cord-335975-m6lkrehi 398 8 % % NN cord-335975-m6lkrehi 398 9 ) ) -RRB- cord-335975-m6lkrehi 398 10 in in IN cord-335975-m6lkrehi 398 11 the the DT cord-335975-m6lkrehi 398 12 epinephrine epinephrine NN cord-335975-m6lkrehi 398 13 group group NN cord-335975-m6lkrehi 398 14 and and CC cord-335975-m6lkrehi 398 15 in in IN cord-335975-m6lkrehi 398 16 1/30 1/30 CD cord-335975-m6lkrehi 398 17 ( ( -LRB- cord-335975-m6lkrehi 398 18 3 3 CD cord-335975-m6lkrehi 398 19 % % NN cord-335975-m6lkrehi 398 20 ) ) -RRB- cord-335975-m6lkrehi 398 21 in in IN cord-335975-m6lkrehi 398 22 the the DT cord-335975-m6lkrehi 398 23 norepinephrine norepinephrine NN cord-335975-m6lkrehi 398 24 group group NN cord-335975-m6lkrehi 398 25 ( ( -LRB- cord-335975-m6lkrehi 398 26 p p NN cord-335975-m6lkrehi 398 27 = = SYM cord-335975-m6lkrehi 398 28 0.34 0.34 CD cord-335975-m6lkrehi 399 1 ) ) -RRB- cord-335975-m6lkrehi 399 2 Mortality mortality NN cord-335975-m6lkrehi 399 3 was be VBD cord-335975-m6lkrehi 399 4 11/30 11/30 CD cord-335975-m6lkrehi 399 5 ( ( -LRB- cord-335975-m6lkrehi 399 6 37 37 CD cord-335975-m6lkrehi 399 7 % % NN cord-335975-m6lkrehi 399 8 ) ) -RRB- cord-335975-m6lkrehi 399 9 in in IN cord-335975-m6lkrehi 399 10 the the DT cord-335975-m6lkrehi 399 11 norepinephrine norepinephrine NN cord-335975-m6lkrehi 399 12 group group NN cord-335975-m6lkrehi 399 13 and and CC cord-335975-m6lkrehi 399 14 14/27 14/27 CD cord-335975-m6lkrehi 399 15 ( ( -LRB- cord-335975-m6lkrehi 399 16 52 52 CD cord-335975-m6lkrehi 399 17 % % NN cord-335975-m6lkrehi 399 18 ) ) -RRB- cord-335975-m6lkrehi 399 19 in in IN cord-335975-m6lkrehi 399 20 the the DT cord-335975-m6lkrehi 399 21 epinephrine epinephrine NN cord-335975-m6lkrehi 399 22 group group NN cord-335975-m6lkrehi 399 23 ( ( -LRB- cord-335975-m6lkrehi 399 24 p p NN cord-335975-m6lkrehi 399 25 = = SYM cord-335975-m6lkrehi 399 26 0.25 0.25 CD cord-335975-m6lkrehi 399 27 ) ) -RRB- cord-335975-m6lkrehi 400 1 Epinephrine epinephrine NN cord-335975-m6lkrehi 400 2 use use NN cord-335975-m6lkrehi 400 3 was be VBD cord-335975-m6lkrehi 400 4 associated associate VBN cord-335975-m6lkrehi 400 5 with with IN cord-335975-m6lkrehi 400 6 a a DT cord-335975-m6lkrehi 400 7 trend trend NN cord-335975-m6lkrehi 400 8 to to IN cord-335975-m6lkrehi 400 9 an an DT cord-335975-m6lkrehi 400 10 increased increase VBN cord-335975-m6lkrehi 400 11 risk risk NN cord-335975-m6lkrehi 400 12 of of IN cord-335975-m6lkrehi 400 13 death death NN cord-335975-m6lkrehi 400 14 ( ( -LRB- cord-335975-m6lkrehi 400 15 p p NN cord-335975-m6lkrehi 400 16 = = SYM cord-335975-m6lkrehi 400 17 0.08 0.08 CD cord-335975-m6lkrehi 400 18 ) ) -RRB- cord-335975-m6lkrehi 400 19 and and CC cord-335975-m6lkrehi 400 20 an an DT cord-335975-m6lkrehi 400 21 increased increase VBN cord-335975-m6lkrehi 400 22 risk risk NN cord-335975-m6lkrehi 400 23 of of IN cord-335975-m6lkrehi 400 24 death death NN cord-335975-m6lkrehi 400 25 plus plus CC cord-335975-m6lkrehi 400 26 ECMO ECMO NNP cord-335975-m6lkrehi 400 27 ( ( -LRB- cord-335975-m6lkrehi 400 28 p p NN cord-335975-m6lkrehi 400 29 = = SYM cord-335975-m6lkrehi 400 30 0.031 0.031 CD cord-335975-m6lkrehi 400 31 ) ) -RRB- cord-335975-m6lkrehi 400 32 at at IN cord-335975-m6lkrehi 400 33 7 7 CD cord-335975-m6lkrehi 400 34 days day NNS cord-335975-m6lkrehi 400 35 . . . cord-335975-m6lkrehi 401 1 There there EX cord-335975-m6lkrehi 401 2 was be VBD cord-335975-m6lkrehi 401 3 a a DT cord-335975-m6lkrehi 401 4 trend trend NN cord-335975-m6lkrehi 401 5 for for IN cord-335975-m6lkrehi 401 6 an an DT cord-335975-m6lkrehi 401 7 increased increase VBN cord-335975-m6lkrehi 401 8 risk risk NN cord-335975-m6lkrehi 401 9 of of IN cord-335975-m6lkrehi 401 10 death death NN cord-335975-m6lkrehi 401 11 plus plus CC cord-335975-m6lkrehi 401 12 ECMO ECMO NNP cord-335975-m6lkrehi 401 13 at at IN cord-335975-m6lkrehi 401 14 J28 J28 NNP cord-335975-m6lkrehi 401 15 ( ( -LRB- cord-335975-m6lkrehi 401 16 p p NN cord-335975-m6lkrehi 401 17 = = SYM cord-335975-m6lkrehi 401 18 0.064 0.064 CD cord-335975-m6lkrehi 401 19 ) ) -RRB- cord-335975-m6lkrehi 401 20 . . . cord-335975-m6lkrehi 402 1 Conclusion conclusion NN cord-335975-m6lkrehi 402 2 : : : cord-335975-m6lkrehi 403 1 In in IN cord-335975-m6lkrehi 403 2 patients patient NNS cord-335975-m6lkrehi 403 3 with with IN cord-335975-m6lkrehi 403 4 cardiogenic cardiogenic JJ cord-335975-m6lkrehi 403 5 shock shock NN cord-335975-m6lkrehi 403 6 following follow VBG cord-335975-m6lkrehi 403 7 myocardial myocardial JJ cord-335975-m6lkrehi 403 8 infarction infarction NN cord-335975-m6lkrehi 403 9 , , , cord-335975-m6lkrehi 403 10 epinephrine epinephrine NN cord-335975-m6lkrehi 403 11 use use NN cord-335975-m6lkrehi 403 12 was be VBD cord-335975-m6lkrehi 403 13 associated associate VBN cord-335975-m6lkrehi 403 14 with with IN cord-335975-m6lkrehi 403 15 a a DT cord-335975-m6lkrehi 403 16 lactic lactic JJ cord-335975-m6lkrehi 403 17 acidosis acidosis NN cord-335975-m6lkrehi 403 18 , , , cord-335975-m6lkrehi 403 19 an an DT cord-335975-m6lkrehi 403 20 higher high JJR cord-335975-m6lkrehi 403 21 incidence incidence NN cord-335975-m6lkrehi 403 22 of of IN cord-335975-m6lkrehi 403 23 refractory refractory JJ cord-335975-m6lkrehi 403 24 shock shock NN cord-335975-m6lkrehi 403 25 and and CC cord-335975-m6lkrehi 403 26 an an DT cord-335975-m6lkrehi 403 27 increased increase VBN cord-335975-m6lkrehi 403 28 risk risk NN cord-335975-m6lkrehi 403 29 of of IN cord-335975-m6lkrehi 403 30 death death NN cord-335975-m6lkrehi 403 31 plus plus CC cord-335975-m6lkrehi 403 32 ECMO ECMO NNP cord-335975-m6lkrehi 403 33 at at IN cord-335975-m6lkrehi 403 34 J7 J7 NNP cord-335975-m6lkrehi 403 35 . . . cord-335975-m6lkrehi 404 1 High high JJ cord-335975-m6lkrehi 404 2 dose dose NN cord-335975-m6lkrehi 404 3 immunoglobulins immunoglobulin NNS cord-335975-m6lkrehi 404 4 in in IN cord-335975-m6lkrehi 404 5 toxic toxic JJ cord-335975-m6lkrehi 404 6 shock shock NN cord-335975-m6lkrehi 404 7 syndrome syndrome NN cord-335975-m6lkrehi 404 8 in in IN cord-335975-m6lkrehi 404 9 children child NNS cord-335975-m6lkrehi 404 10 : : : cord-335975-m6lkrehi 404 11 a a DT cord-335975-m6lkrehi 404 12 pilot pilot NN cord-335975-m6lkrehi 404 13 randomized randomize VBN cord-335975-m6lkrehi 404 14 controlled control VBN cord-335975-m6lkrehi 404 15 study study NN cord-335975-m6lkrehi 404 16 ( ( -LRB- cord-335975-m6lkrehi 404 17 IGHN IGHN NNP cord-335975-m6lkrehi 404 18 study study NN cord-335975-m6lkrehi 404 19 ) ) -RRB- cord-335975-m6lkrehi 405 1 Javouhey Javouhey NNP cord-335975-m6lkrehi 405 2 Etienne Etienne NNP cord-335975-m6lkrehi 405 3 1 1 CD cord-335975-m6lkrehi 405 4 , , , cord-335975-m6lkrehi 405 5 Leteurtre Leteurtre NNP cord-335975-m6lkrehi 405 6 Stéphane Stéphane NNP cord-335975-m6lkrehi 405 7 2 2 CD cord-335975-m6lkrehi 405 8 , , , cord-335975-m6lkrehi 405 9 Tissières Tissières NNPS cord-335975-m6lkrehi 405 10 Pierre Pierre NNP cord-335975-m6lkrehi 405 11 3 3 CD cord-335975-m6lkrehi 405 12 , , , cord-335975-m6lkrehi 405 13 Joram Joram NNP cord-335975-m6lkrehi 405 14 Nicolas Nicolas NNP cord-335975-m6lkrehi 405 15 4 4 CD cord-335975-m6lkrehi 405 16 , , , cord-335975-m6lkrehi 405 17 Wroblewski Wroblewski NNP cord-335975-m6lkrehi 405 18 Isabelle Isabelle NNP cord-335975-m6lkrehi 405 19 5 5 CD cord-335975-m6lkrehi 405 20 , , , cord-335975-m6lkrehi 405 21 Ginhoux Ginhoux NNP cord-335975-m6lkrehi 405 22 Tiphanie Tiphanie NNP cord-335975-m6lkrehi 405 23 6 6 CD cord-335975-m6lkrehi 405 24 , , , cord-335975-m6lkrehi 405 25 Dauger Dauger NNP cord-335975-m6lkrehi 405 26 Stéphane Stéphane NNP cord-335975-m6lkrehi 405 27 7 7 CD cord-335975-m6lkrehi 405 28 , , , cord-335975-m6lkrehi 405 29 Kassai Kassai NNP cord-335975-m6lkrehi 405 30 Behrouz Behrouz NNP cord-335975-m6lkrehi 406 1 8 8 CD cord-335975-m6lkrehi 406 2 1 1 CD cord-335975-m6lkrehi 406 3 Hôpital Hôpital NNP cord-335975-m6lkrehi 406 4 Mère Mère NNP cord-335975-m6lkrehi 406 5 Enfant Enfant NNP cord-335975-m6lkrehi 406 6 , , , cord-335975-m6lkrehi 406 7 Bron Bron NNP cord-335975-m6lkrehi 406 8 , , , cord-335975-m6lkrehi 406 9 France France NNP cord-335975-m6lkrehi 406 10 ; ; : cord-335975-m6lkrehi 406 11 2 2 CD cord-335975-m6lkrehi 406 12 Hôpital Hôpital NNP cord-335975-m6lkrehi 406 13 Jeanne Jeanne NNP cord-335975-m6lkrehi 406 14 de de NNP cord-335975-m6lkrehi 406 15 Flandre Flandre NNP cord-335975-m6lkrehi 406 16 , , , cord-335975-m6lkrehi 406 17 Lille Lille NNP cord-335975-m6lkrehi 406 18 , , , cord-335975-m6lkrehi 406 19 France France NNP cord-335975-m6lkrehi 406 20 ; ; : cord-335975-m6lkrehi 406 21 3 3 CD cord-335975-m6lkrehi 406 22 Hôpital Hôpital NNP cord-335975-m6lkrehi 406 23 du du NNP cord-335975-m6lkrehi 406 24 Kremlin Kremlin NNP cord-335975-m6lkrehi 406 25 - - HYPH cord-335975-m6lkrehi 406 26 Bicêtre Bicêtre NNP cord-335975-m6lkrehi 406 27 , , , cord-335975-m6lkrehi 406 28 Le Le NNP cord-335975-m6lkrehi 406 29 Kremlin Kremlin NNP cord-335975-m6lkrehi 406 30 - - HYPH cord-335975-m6lkrehi 406 31 Bicêtre Bicêtre NNP cord-335975-m6lkrehi 406 32 , , , cord-335975-m6lkrehi 406 33 France France NNP cord-335975-m6lkrehi 406 34 ; ; : cord-335975-m6lkrehi 406 35 4 4 CD cord-335975-m6lkrehi 406 36 CHU CHU NNP cord-335975-m6lkrehi 406 37 Nantes Nantes NNP cord-335975-m6lkrehi 406 38 , , , cord-335975-m6lkrehi 406 39 Nantes Nantes NNP cord-335975-m6lkrehi 406 40 , , , cord-335975-m6lkrehi 406 41 France France NNP cord-335975-m6lkrehi 406 42 ; ; : cord-335975-m6lkrehi 406 43 5 5 CD cord-335975-m6lkrehi 406 44 CHU CHU NNP cord-335975-m6lkrehi 406 45 Grenoble Grenoble NNP cord-335975-m6lkrehi 406 46 , , , cord-335975-m6lkrehi 406 47 La La NNP cord-335975-m6lkrehi 406 48 Tronche Tronche NNP cord-335975-m6lkrehi 406 49 , , , cord-335975-m6lkrehi 406 50 France France NNP cord-335975-m6lkrehi 406 51 ; ; : cord-335975-m6lkrehi 407 1 6 6 CD cord-335975-m6lkrehi 407 2 Hospices Hospices NNPS cord-335975-m6lkrehi 407 3 Civils Civils NNP cord-335975-m6lkrehi 407 4 de de NNP cord-335975-m6lkrehi 407 5 Lyon Lyon NNP cord-335975-m6lkrehi 407 6 , , , cord-335975-m6lkrehi 407 7 Bron Bron NNP cord-335975-m6lkrehi 407 8 , , , cord-335975-m6lkrehi 407 9 France France NNP cord-335975-m6lkrehi 407 10 ; ; : cord-335975-m6lkrehi 407 11 7 7 CD cord-335975-m6lkrehi 407 12 Hôpital Hôpital NNP cord-335975-m6lkrehi 407 13 Robert Robert NNP cord-335975-m6lkrehi 407 14 Debré Debré NNP cord-335975-m6lkrehi 407 15 , , , cord-335975-m6lkrehi 407 16 Paris Paris NNP cord-335975-m6lkrehi 407 17 , , , cord-335975-m6lkrehi 407 18 France France NNP cord-335975-m6lkrehi 407 19 ; ; : cord-335975-m6lkrehi 407 20 8 8 CD cord-335975-m6lkrehi 407 21 Hospices Hospices NNPS cord-335975-m6lkrehi 407 22 Civils Civils NNP cord-335975-m6lkrehi 407 23 de de NNP cord-335975-m6lkrehi 407 24 Lyon Lyon NNP cord-335975-m6lkrehi 407 25 , , , cord-335975-m6lkrehi 407 26 Bron Bron NNP cord-335975-m6lkrehi 407 27 , , , cord-335975-m6lkrehi 407 28 France France NNP cord-335975-m6lkrehi 407 29 Correspondence Correspondence NNP cord-335975-m6lkrehi 407 30 : : : cord-335975-m6lkrehi 408 1 Javouhey Javouhey NNP cord-335975-m6lkrehi 408 2 Etienne Etienne NNP cord-335975-m6lkrehi 409 1 -etienne.javouhey@chu-lyon.fr -etienne.javouhey@chu-lyon.fr : cord-335975-m6lkrehi 409 2 Annals Annals NNP cord-335975-m6lkrehi 409 3 of of IN cord-335975-m6lkrehi 409 4 Intensive Intensive NNP cord-335975-m6lkrehi 409 5 Care Care NNP cord-335975-m6lkrehi 409 6 2018 2018 CD cord-335975-m6lkrehi 409 7 , , , cord-335975-m6lkrehi 409 8 8(Suppl 8(suppl CD cord-335975-m6lkrehi 409 9 1):CO-67 1):co-67 CD cord-335975-m6lkrehi 409 10 Introduction introduction NN cord-335975-m6lkrehi 409 11 : : : cord-335975-m6lkrehi 410 1 Superantigen Superantigen NNP cord-335975-m6lkrehi 410 2 toxins toxin NNS cord-335975-m6lkrehi 410 3 synthesized synthesize VBN cord-335975-m6lkrehi 410 4 by by IN cord-335975-m6lkrehi 410 5 S. S. NNP cord-335975-m6lkrehi 410 6 aureus aureus NN cord-335975-m6lkrehi 410 7 or or CC cord-335975-m6lkrehi 410 8 by by IN cord-335975-m6lkrehi 410 9 S. S. NNP cord-335975-m6lkrehi 410 10 pyogenes pyogene NNS cord-335975-m6lkrehi 410 11 are be VBP cord-335975-m6lkrehi 410 12 responsible responsible JJ cord-335975-m6lkrehi 410 13 for for IN cord-335975-m6lkrehi 410 14 toxic toxic JJ cord-335975-m6lkrehi 410 15 shock shock NN cord-335975-m6lkrehi 410 16 syndromes syndrome NNS cord-335975-m6lkrehi 410 17 ( ( -LRB- cord-335975-m6lkrehi 410 18 TSS TSS NNP cord-335975-m6lkrehi 410 19 ) ) -RRB- cord-335975-m6lkrehi 410 20 which which WDT cord-335975-m6lkrehi 410 21 lethality lethality NN cord-335975-m6lkrehi 410 22 can can MD cord-335975-m6lkrehi 410 23 reach reach VB cord-335975-m6lkrehi 410 24 28 28 CD cord-335975-m6lkrehi 410 25 % % NN cord-335975-m6lkrehi 410 26 . . . cord-335975-m6lkrehi 411 1 High high JJ cord-335975-m6lkrehi 411 2 dose dose NN cord-335975-m6lkrehi 411 3 intravenous intravenous JJ cord-335975-m6lkrehi 411 4 immunoglobulins immunoglobulin NNS cord-335975-m6lkrehi 411 5 ( ( -LRB- cord-335975-m6lkrehi 411 6 IVIG IVIG NNP cord-335975-m6lkrehi 411 7 ) ) -RRB- cord-335975-m6lkrehi 411 8 , , , cord-335975-m6lkrehi 411 9 able able JJ cord-335975-m6lkrehi 411 10 to to TO cord-335975-m6lkrehi 411 11 neutralize neutralize VB cord-335975-m6lkrehi 411 12 these these DT cord-335975-m6lkrehi 411 13 toxins toxin NNS cord-335975-m6lkrehi 411 14 , , , cord-335975-m6lkrehi 411 15 are be VBP cord-335975-m6lkrehi 411 16 frequently frequently RB cord-335975-m6lkrehi 411 17 used use VBN cord-335975-m6lkrehi 411 18 even even RB cord-335975-m6lkrehi 411 19 tough tough JJ cord-335975-m6lkrehi 411 20 evidence evidence NN cord-335975-m6lkrehi 411 21 of of IN cord-335975-m6lkrehi 411 22 its -PRON- PRP$ cord-335975-m6lkrehi 411 23 efficacy efficacy NN cord-335975-m6lkrehi 411 24 is be VBZ cord-335975-m6lkrehi 411 25 not not RB cord-335975-m6lkrehi 411 26 supported support VBN cord-335975-m6lkrehi 411 27 by by IN cord-335975-m6lkrehi 411 28 randomized randomized JJ cord-335975-m6lkrehi 411 29 controlled control VBN cord-335975-m6lkrehi 411 30 study study NN cord-335975-m6lkrehi 411 31 ( ( -LRB- cord-335975-m6lkrehi 411 32 RCT RCT NNP cord-335975-m6lkrehi 411 33 ) ) -RRB- cord-335975-m6lkrehi 411 34 . . . cord-335975-m6lkrehi 412 1 Moreover moreover RB cord-335975-m6lkrehi 412 2 , , , cord-335975-m6lkrehi 412 3 IVIG IVIG NNP cord-335975-m6lkrehi 412 4 are be VBP cord-335975-m6lkrehi 412 5 expensive expensive JJ cord-335975-m6lkrehi 412 6 and and CC cord-335975-m6lkrehi 412 7 possibly possibly RB cord-335975-m6lkrehi 412 8 harmful harmful JJ cord-335975-m6lkrehi 412 9 . . . cord-335975-m6lkrehi 413 1 Before before IN cord-335975-m6lkrehi 413 2 conducting conduct VBG cord-335975-m6lkrehi 413 3 a a DT cord-335975-m6lkrehi 413 4 RCT RCT NNP cord-335975-m6lkrehi 413 5 , , , cord-335975-m6lkrehi 413 6 a a DT cord-335975-m6lkrehi 413 7 pilot pilot NN cord-335975-m6lkrehi 413 8 study study NN cord-335975-m6lkrehi 413 9 was be VBD cord-335975-m6lkrehi 413 10 first first RB cord-335975-m6lkrehi 413 11 designed design VBN cord-335975-m6lkrehi 413 12 to to TO cord-335975-m6lkrehi 413 13 assess assess VB cord-335975-m6lkrehi 413 14 the the DT cord-335975-m6lkrehi 413 15 feasibility feasibility NN cord-335975-m6lkrehi 413 16 in in IN cord-335975-m6lkrehi 413 17 the the DT cord-335975-m6lkrehi 413 18 context context NN cord-335975-m6lkrehi 413 19 of of IN cord-335975-m6lkrehi 413 20 pediatric pediatric JJ cord-335975-m6lkrehi 413 21 critical critical JJ cord-335975-m6lkrehi 413 22 care care NN cord-335975-m6lkrehi 413 23 . . . cord-335975-m6lkrehi 414 1 Patients patient NNS cord-335975-m6lkrehi 414 2 and and CC cord-335975-m6lkrehi 414 3 methods method NNS cord-335975-m6lkrehi 414 4 : : : cord-335975-m6lkrehi 414 5 A a DT cord-335975-m6lkrehi 414 6 double double JJ cord-335975-m6lkrehi 414 7 blinded blind VBN cord-335975-m6lkrehi 414 8 RCT RCT NNP cord-335975-m6lkrehi 414 9 was be VBD cord-335975-m6lkrehi 414 10 performed perform VBN cord-335975-m6lkrehi 414 11 comparing compare VBG cord-335975-m6lkrehi 414 12 2 2 CD cord-335975-m6lkrehi 414 13 g g NN cord-335975-m6lkrehi 414 14 kg kg NNS cord-335975-m6lkrehi 414 15 of of IN cord-335975-m6lkrehi 414 16 IVIG IVIG NNP cord-335975-m6lkrehi 414 17 to to IN cord-335975-m6lkrehi 414 18 isovolumic isovolumic NNP cord-335975-m6lkrehi 414 19 4 4 CD cord-335975-m6lkrehi 414 20 % % NN cord-335975-m6lkrehi 414 21 albumin albumin NN cord-335975-m6lkrehi 414 22 perfusion perfusion NN cord-335975-m6lkrehi 414 23 within within IN cord-335975-m6lkrehi 414 24 the the DT cord-335975-m6lkrehi 414 25 first first JJ cord-335975-m6lkrehi 414 26 12 12 CD cord-335975-m6lkrehi 414 27 h h NN cord-335975-m6lkrehi 414 28 of of IN cord-335975-m6lkrehi 414 29 TSS TSS NNP cord-335975-m6lkrehi 414 30 in in IN cord-335975-m6lkrehi 414 31 children child NNS cord-335975-m6lkrehi 414 32 aged age VBN cord-335975-m6lkrehi 414 33 between between IN cord-335975-m6lkrehi 414 34 1 1 CD cord-335975-m6lkrehi 414 35 month month NN cord-335975-m6lkrehi 414 36 to to IN cord-335975-m6lkrehi 414 37 17 17 CD cord-335975-m6lkrehi 414 38 years year NNS cord-335975-m6lkrehi 414 39 . . . cord-335975-m6lkrehi 415 1 A a DT cord-335975-m6lkrehi 415 2 priori priori FW cord-335975-m6lkrehi 415 3 criteria criterion NNS cord-335975-m6lkrehi 415 4 to to TO cord-335975-m6lkrehi 415 5 determine determine VB cord-335975-m6lkrehi 415 6 the the DT cord-335975-m6lkrehi 415 7 feasibility feasibility NN cord-335975-m6lkrehi 415 8 were be VBD cord-335975-m6lkrehi 415 9 defined define VBN cord-335975-m6lkrehi 415 10 as as IN cord-335975-m6lkrehi 415 11 a a DT cord-335975-m6lkrehi 415 12 rate rate NN cord-335975-m6lkrehi 415 13 of of IN cord-335975-m6lkrehi 415 14 inclusion inclusion NN cord-335975-m6lkrehi 415 15 among among IN cord-335975-m6lkrehi 415 16 eligible eligible JJ cord-335975-m6lkrehi 415 17 patients patient NNS cord-335975-m6lkrehi 415 18 > > XX cord-335975-m6lkrehi 415 19 50 50 CD cord-335975-m6lkrehi 415 20 % % NN cord-335975-m6lkrehi 415 21 , , , cord-335975-m6lkrehi 415 22 a a DT cord-335975-m6lkrehi 415 23 rate rate NN cord-335975-m6lkrehi 415 24 of of IN cord-335975-m6lkrehi 415 25 protocol protocol NN cord-335975-m6lkrehi 415 26 's 's POS cord-335975-m6lkrehi 415 27 deviations deviation NNS cord-335975-m6lkrehi 415 28 < < XX cord-335975-m6lkrehi 415 29 30 30 CD cord-335975-m6lkrehi 415 30 % % NN cord-335975-m6lkrehi 415 31 ( ( -LRB- cord-335975-m6lkrehi 415 32 treatment treatment NN cord-335975-m6lkrehi 415 33 delivery delivery NN cord-335975-m6lkrehi 415 34 , , , cord-335975-m6lkrehi 415 35 non non JJ cord-335975-m6lkrehi 415 36 - - JJ cord-335975-m6lkrehi 415 37 respect respect NN cord-335975-m6lkrehi 415 38 of of IN cord-335975-m6lkrehi 415 39 blinding blind VBG cord-335975-m6lkrehi 415 40 , , , cord-335975-m6lkrehi 415 41 premature premature JJ cord-335975-m6lkrehi 415 42 stop stop NN cord-335975-m6lkrehi 415 43 ) ) -RRB- cord-335975-m6lkrehi 415 44 , , , cord-335975-m6lkrehi 415 45 and and CC cord-335975-m6lkrehi 415 46 by by IN cord-335975-m6lkrehi 415 47 the the DT cord-335975-m6lkrehi 415 48 practical practical JJ cord-335975-m6lkrehi 415 49 and and CC cord-335975-m6lkrehi 415 50 financial financial JJ cord-335975-m6lkrehi 415 51 aspects aspect NNS cord-335975-m6lkrehi 415 52 of of IN cord-335975-m6lkrehi 415 53 the the DT cord-335975-m6lkrehi 415 54 protocol protocol NN cord-335975-m6lkrehi 415 55 . . . cord-335975-m6lkrehi 416 1 Secondary secondary JJ cord-335975-m6lkrehi 416 2 objectives objective NNS cord-335975-m6lkrehi 416 3 were be VBD cord-335975-m6lkrehi 416 4 to to TO cord-335975-m6lkrehi 416 5 assess assess VB cord-335975-m6lkrehi 416 6 the the DT cord-335975-m6lkrehi 416 7 efficacy efficacy NN cord-335975-m6lkrehi 416 8 of of IN cord-335975-m6lkrehi 416 9 IVIG IVIG NNP cord-335975-m6lkrehi 416 10 on on IN cord-335975-m6lkrehi 416 11 organ organ NN cord-335975-m6lkrehi 416 12 dysfunction dysfunction NN cord-335975-m6lkrehi 416 13 ( ( -LRB- cord-335975-m6lkrehi 416 14 using use VBG cord-335975-m6lkrehi 416 15 Pelod-2 Pelod-2 NNP cord-335975-m6lkrehi 416 16 score score NN cord-335975-m6lkrehi 416 17 ) ) -RRB- cord-335975-m6lkrehi 416 18 , , , cord-335975-m6lkrehi 416 19 on on IN cord-335975-m6lkrehi 416 20 mortality mortality NN cord-335975-m6lkrehi 416 21 at at IN cord-335975-m6lkrehi 416 22 day day NN cord-335975-m6lkrehi 416 23 60 60 CD cord-335975-m6lkrehi 416 24 and and CC cord-335975-m6lkrehi 416 25 their -PRON- PRP$ cord-335975-m6lkrehi 416 26 safety safety NN cord-335975-m6lkrehi 416 27 . . . cord-335975-m6lkrehi 417 1 The the DT cord-335975-m6lkrehi 417 2 study study NN cord-335975-m6lkrehi 417 3 was be VBD cord-335975-m6lkrehi 417 4 promoted promote VBN cord-335975-m6lkrehi 417 5 by by IN cord-335975-m6lkrehi 417 6 the the DT cord-335975-m6lkrehi 417 7 Hospices Hospices NNP cord-335975-m6lkrehi 417 8 Civils Civils NNP cord-335975-m6lkrehi 417 9 of of IN cord-335975-m6lkrehi 417 10 Lyon Lyon NNP cord-335975-m6lkrehi 417 11 , , , cord-335975-m6lkrehi 417 12 approved approve VBN cord-335975-m6lkrehi 417 13 by by IN cord-335975-m6lkrehi 417 14 the the DT cord-335975-m6lkrehi 417 15 CPP CPP NNP cord-335975-m6lkrehi 417 16 Sud Sud NNP cord-335975-m6lkrehi 417 17 - - HYPH cord-335975-m6lkrehi 417 18 Est Est NNP cord-335975-m6lkrehi 417 19 and and CC cord-335975-m6lkrehi 417 20 registered register VBN cord-335975-m6lkrehi 417 21 at at IN cord-335975-m6lkrehi 417 22 clinical clinical JJ cord-335975-m6lkrehi 417 23 trial trial NN cord-335975-m6lkrehi 417 24 ( ( -LRB- cord-335975-m6lkrehi 417 25 NCT02219165 NCT02219165 NNP cord-335975-m6lkrehi 417 26 ) ) -RRB- cord-335975-m6lkrehi 417 27 . . . cord-335975-m6lkrehi 418 1 Inform inform VB cord-335975-m6lkrehi 418 2 consent consent NN cord-335975-m6lkrehi 418 3 from from IN cord-335975-m6lkrehi 418 4 both both DT cord-335975-m6lkrehi 418 5 parents parent NNS cord-335975-m6lkrehi 418 6 was be VBD cord-335975-m6lkrehi 418 7 required require VBN cord-335975-m6lkrehi 418 8 before before IN cord-335975-m6lkrehi 418 9 randomization randomization NN cord-335975-m6lkrehi 418 10 . . . cord-335975-m6lkrehi 419 1 This this DT cord-335975-m6lkrehi 419 2 study study NN cord-335975-m6lkrehi 419 3 was be VBD cord-335975-m6lkrehi 419 4 funded fund VBN cord-335975-m6lkrehi 419 5 by by IN cord-335975-m6lkrehi 419 6 CSL CSL NNP cord-335975-m6lkrehi 419 7 - - HYPH cord-335975-m6lkrehi 419 8 Behring Behring NNP cord-335975-m6lkrehi 419 9 company company NN cord-335975-m6lkrehi 419 10 . . . cord-335975-m6lkrehi 420 1 Results result NNS cord-335975-m6lkrehi 420 2 : : : cord-335975-m6lkrehi 421 1 During during IN cord-335975-m6lkrehi 421 2 the the DT cord-335975-m6lkrehi 421 3 30 30 CD cord-335975-m6lkrehi 421 4 months month NNS cord-335975-m6lkrehi 421 5 study study NN cord-335975-m6lkrehi 421 6 period period NN cord-335975-m6lkrehi 421 7 , , , cord-335975-m6lkrehi 421 8 21 21 CD cord-335975-m6lkrehi 421 9 patients patient NNS cord-335975-m6lkrehi 421 10 were be VBD cord-335975-m6lkrehi 421 11 included include VBN cord-335975-m6lkrehi 421 12 in in IN cord-335975-m6lkrehi 421 13 9 9 CD cord-335975-m6lkrehi 421 14 centers center NNS cord-335975-m6lkrehi 421 15 . . . cord-335975-m6lkrehi 422 1 The the DT cord-335975-m6lkrehi 422 2 inclusion inclusion NN cord-335975-m6lkrehi 422 3 rate rate NN cord-335975-m6lkrehi 422 4 was be VBD cord-335975-m6lkrehi 422 5 of of IN cord-335975-m6lkrehi 422 6 71 71 CD cord-335975-m6lkrehi 422 7 % % NN cord-335975-m6lkrehi 422 8 ( ( -LRB- cord-335975-m6lkrehi 422 9 5 5 CD cord-335975-m6lkrehi 422 10 parent parent NN cord-335975-m6lkrehi 422 11 's 's POS cord-335975-m6lkrehi 422 12 refusals refusal NNS cord-335975-m6lkrehi 422 13 , , , cord-335975-m6lkrehi 422 14 3 3 CD cord-335975-m6lkrehi 422 15 parents parent NNS cord-335975-m6lkrehi 422 16 were be VBD cord-335975-m6lkrehi 422 17 absent absent JJ cord-335975-m6lkrehi 422 18 at at IN cord-335975-m6lkrehi 422 19 admission admission NN cord-335975-m6lkrehi 422 20 ) ) -RRB- cord-335975-m6lkrehi 422 21 . . . cord-335975-m6lkrehi 423 1 Two two CD cord-335975-m6lkrehi 423 2 patients patient NNS cord-335975-m6lkrehi 423 3 were be VBD cord-335975-m6lkrehi 423 4 wrongly wrongly RB cord-335975-m6lkrehi 423 5 included include VBN cord-335975-m6lkrehi 423 6 ( ( -LRB- cord-335975-m6lkrehi 423 7 pneumococcal pneumococcal JJ cord-335975-m6lkrehi 423 8 shocks shock NNS cord-335975-m6lkrehi 423 9 ) ) -RRB- cord-335975-m6lkrehi 423 10 , , , cord-335975-m6lkrehi 423 11 one one CD cord-335975-m6lkrehi 423 12 patient patient NN cord-335975-m6lkrehi 423 13 did do VBD cord-335975-m6lkrehi 423 14 n't not RB cord-335975-m6lkrehi 423 15 receive receive VB cord-335975-m6lkrehi 423 16 the the DT cord-335975-m6lkrehi 423 17 treatment treatment NN cord-335975-m6lkrehi 423 18 because because IN cord-335975-m6lkrehi 423 19 he -PRON- PRP cord-335975-m6lkrehi 423 20 was be VBD cord-335975-m6lkrehi 423 21 transferred transfer VBN cord-335975-m6lkrehi 423 22 for for IN cord-335975-m6lkrehi 423 23 ECMO ECMO NNP cord-335975-m6lkrehi 423 24 in in IN cord-335975-m6lkrehi 423 25 a a DT cord-335975-m6lkrehi 423 26 non non JJ cord-335975-m6lkrehi 423 27 - - JJ cord-335975-m6lkrehi 423 28 investigator investigator JJ cord-335975-m6lkrehi 423 29 center center NN cord-335975-m6lkrehi 423 30 , , , cord-335975-m6lkrehi 423 31 three three CD cord-335975-m6lkrehi 423 32 patients patient NNS cord-335975-m6lkrehi 423 33 were be VBD cord-335975-m6lkrehi 423 34 treated treat VBN cord-335975-m6lkrehi 423 35 after after IN cord-335975-m6lkrehi 423 36 12H 12H NNP cord-335975-m6lkrehi 423 37 , , , cord-335975-m6lkrehi 423 38 and and CC cord-335975-m6lkrehi 423 39 in in IN cord-335975-m6lkrehi 423 40 two two CD cord-335975-m6lkrehi 423 41 patients patient NNS cord-335975-m6lkrehi 423 42 one one CD cord-335975-m6lkrehi 423 43 bottle bottle NN cord-335975-m6lkrehi 423 44 of of IN cord-335975-m6lkrehi 423 45 treatment treatment NN cord-335975-m6lkrehi 423 46 was be VBD cord-335975-m6lkrehi 423 47 missing miss VBG cord-335975-m6lkrehi 423 48 . . . cord-335975-m6lkrehi 424 1 The the DT cord-335975-m6lkrehi 424 2 blinding blinding NN cord-335975-m6lkrehi 424 3 was be VBD cord-335975-m6lkrehi 424 4 well well RB cord-335975-m6lkrehi 424 5 respected respected JJ cord-335975-m6lkrehi 424 6 . . . cord-335975-m6lkrehi 425 1 Missing miss VBG cord-335975-m6lkrehi 425 2 data datum NNS cord-335975-m6lkrehi 425 3 on on IN cord-335975-m6lkrehi 425 4 the the DT cord-335975-m6lkrehi 425 5 Pelod2 Pelod2 NNP cord-335975-m6lkrehi 425 6 score score NN cord-335975-m6lkrehi 425 7 and and CC cord-335975-m6lkrehi 425 8 mortality mortality NN cord-335975-m6lkrehi 425 9 was be VBD cord-335975-m6lkrehi 425 10 lower low JJR cord-335975-m6lkrehi 425 11 than than IN cord-335975-m6lkrehi 425 12 10 10 CD cord-335975-m6lkrehi 425 13 % % NN cord-335975-m6lkrehi 425 14 , , , cord-335975-m6lkrehi 425 15 and and CC cord-335975-m6lkrehi 425 16 no no DT cord-335975-m6lkrehi 425 17 premature premature JJ cord-335975-m6lkrehi 425 18 stop stop NN cord-335975-m6lkrehi 425 19 was be VBD cord-335975-m6lkrehi 425 20 reported report VBN cord-335975-m6lkrehi 425 21 . . . cord-335975-m6lkrehi 426 1 The the DT cord-335975-m6lkrehi 426 2 eCRF ecrf JJ cord-335975-m6lkrehi 426 3 completion completion NN cord-335975-m6lkrehi 426 4 was be VBD cord-335975-m6lkrehi 426 5 judged judge VBN cord-335975-m6lkrehi 426 6 easy easy JJ cord-335975-m6lkrehi 426 7 by by IN cord-335975-m6lkrehi 426 8 investigators investigator NNS cord-335975-m6lkrehi 426 9 . . . cord-335975-m6lkrehi 427 1 The the DT cord-335975-m6lkrehi 427 2 inclusion inclusion NN cord-335975-m6lkrehi 427 3 of of IN cord-335975-m6lkrehi 427 4 children child NNS cord-335975-m6lkrehi 427 5 within within IN cord-335975-m6lkrehi 427 6 the the DT cord-335975-m6lkrehi 427 7 first first JJ cord-335975-m6lkrehi 427 8 12 12 CD cord-335975-m6lkrehi 427 9 h h NN cord-335975-m6lkrehi 427 10 was be VBD cord-335975-m6lkrehi 427 11 judged judge VBN cord-335975-m6lkrehi 427 12 challenging challenging JJ cord-335975-m6lkrehi 427 13 . . . cord-335975-m6lkrehi 428 1 The the DT cord-335975-m6lkrehi 428 2 treatment treatment NN cord-335975-m6lkrehi 428 3 delivery delivery NN cord-335975-m6lkrehi 428 4 had have VBD cord-335975-m6lkrehi 428 5 to to TO cord-335975-m6lkrehi 428 6 be be VB cord-335975-m6lkrehi 428 7 improved improve VBN cord-335975-m6lkrehi 428 8 , , , cord-335975-m6lkrehi 428 9 requiring require VBG cord-335975-m6lkrehi 428 10 the the DT cord-335975-m6lkrehi 428 11 help help NN cord-335975-m6lkrehi 428 12 of of IN cord-335975-m6lkrehi 428 13 research research NN cord-335975-m6lkrehi 428 14 assistants assistant NNS cord-335975-m6lkrehi 428 15 . . . cord-335975-m6lkrehi 429 1 Seven seven CD cord-335975-m6lkrehi 429 2 serious serious JJ cord-335975-m6lkrehi 429 3 and and CC cord-335975-m6lkrehi 429 4 one one CD cord-335975-m6lkrehi 429 5 severe severe JJ cord-335975-m6lkrehi 429 6 adverse adverse JJ cord-335975-m6lkrehi 429 7 events event NNS cord-335975-m6lkrehi 429 8 were be VBD cord-335975-m6lkrehi 429 9 registered register VBN cord-335975-m6lkrehi 429 10 , , , cord-335975-m6lkrehi 429 11 all all DT cord-335975-m6lkrehi 429 12 patients patient NNS cord-335975-m6lkrehi 429 13 recovered recover VBD cord-335975-m6lkrehi 429 14 and and CC cord-335975-m6lkrehi 429 15 no no DT cord-335975-m6lkrehi 429 16 death death NN cord-335975-m6lkrehi 429 17 was be VBD cord-335975-m6lkrehi 429 18 reported report VBN cord-335975-m6lkrehi 429 19 . . . cord-335975-m6lkrehi 430 1 Conclusion conclusion NN cord-335975-m6lkrehi 430 2 : : : cord-335975-m6lkrehi 431 1 This this DT cord-335975-m6lkrehi 431 2 pilot pilot NN cord-335975-m6lkrehi 431 3 study study NN cord-335975-m6lkrehi 431 4 suggested suggest VBD cord-335975-m6lkrehi 431 5 that that IN cord-335975-m6lkrehi 431 6 a a DT cord-335975-m6lkrehi 431 7 RCT RCT NNP cord-335975-m6lkrehi 431 8 is be VBZ cord-335975-m6lkrehi 431 9 feasible feasible JJ cord-335975-m6lkrehi 431 10 . . . cord-335975-m6lkrehi 432 1 It -PRON- PRP cord-335975-m6lkrehi 432 2 provides provide VBZ cord-335975-m6lkrehi 432 3 crucial crucial JJ cord-335975-m6lkrehi 432 4 information information NN cord-335975-m6lkrehi 432 5 to to TO cord-335975-m6lkrehi 432 6 improve improve VB cord-335975-m6lkrehi 432 7 the the DT cord-335975-m6lkrehi 432 8 recruitment recruitment NN cord-335975-m6lkrehi 432 9 , , , cord-335975-m6lkrehi 432 10 the the DT cord-335975-m6lkrehi 432 11 respect respect NN cord-335975-m6lkrehi 432 12 of of IN cord-335975-m6lkrehi 432 13 the the DT cord-335975-m6lkrehi 432 14 protocol protocol NN cord-335975-m6lkrehi 432 15 and and CC cord-335975-m6lkrehi 432 16 the the DT cord-335975-m6lkrehi 432 17 correct correct JJ cord-335975-m6lkrehi 432 18 measure measure NN cord-335975-m6lkrehi 432 19 of of IN cord-335975-m6lkrehi 432 20 organ organ NN cord-335975-m6lkrehi 432 21 failure failure NN cord-335975-m6lkrehi 432 22 . . . cord-335975-m6lkrehi 433 1 However however RB cord-335975-m6lkrehi 433 2 , , , cord-335975-m6lkrehi 433 3 inclusion inclusion NN cord-335975-m6lkrehi 433 4 of of IN cord-335975-m6lkrehi 433 5 international international JJ cord-335975-m6lkrehi 433 6 centers center NNS cord-335975-m6lkrehi 433 7 is be VBZ cord-335975-m6lkrehi 433 8 necessary necessary JJ cord-335975-m6lkrehi 433 9 to to TO cord-335975-m6lkrehi 433 10 attain attain VB cord-335975-m6lkrehi 433 11 the the DT cord-335975-m6lkrehi 433 12 sample sample NN cord-335975-m6lkrehi 433 13 size size NN cord-335975-m6lkrehi 433 14 required require VBN cord-335975-m6lkrehi 433 15 . . . cord-335975-m6lkrehi 434 1 indirect indirect JJ cord-335975-m6lkrehi 434 2 calorimetry calorimetry NN cord-335975-m6lkrehi 434 3 - - HYPH cord-335975-m6lkrehi 434 4 based base VBN cord-335975-m6lkrehi 434 5 method method NN cord-335975-m6lkrehi 434 6 for for IN cord-335975-m6lkrehi 434 7 the the DT cord-335975-m6lkrehi 434 8 work work NN cord-335975-m6lkrehi 434 9 of of IN cord-335975-m6lkrehi 434 10 breathing breathing NN cord-335975-m6lkrehi 434 11 assessment assessment NN cord-335975-m6lkrehi 434 12 when when WRB cord-335975-m6lkrehi 434 13 compared compare VBN cord-335975-m6lkrehi 434 14 to to IN cord-335975-m6lkrehi 434 15 esophageal esophageal JJ cord-335975-m6lkrehi 434 16 pressure pressure NN cord-335975-m6lkrehi 434 17 ( ( -LRB- cord-335975-m6lkrehi 434 18 Pes Pes NNP cord-335975-m6lkrehi 434 19 ) ) -RRB- cord-335975-m6lkrehi 434 20 measurement measurement NN cord-335975-m6lkrehi 434 21 and and CC cord-335975-m6lkrehi 434 22 Electrical Electrical NNP cord-335975-m6lkrehi 434 23 Activity Activity NNP cord-335975-m6lkrehi 434 24 of of IN cord-335975-m6lkrehi 434 25 the the DT cord-335975-m6lkrehi 434 26 Diaphragm diaphragm NN cord-335975-m6lkrehi 434 27 ( ( -LRB- cord-335975-m6lkrehi 434 28 EAdi EAdi NNP cord-335975-m6lkrehi 434 29 ) ) -RRB- cord-335975-m6lkrehi 434 30 during during IN cord-335975-m6lkrehi 434 31 a a DT cord-335975-m6lkrehi 434 32 spontaneous spontaneous JJ cord-335975-m6lkrehi 434 33 breathing breathing NN cord-335975-m6lkrehi 434 34 trial trial NN cord-335975-m6lkrehi 434 35 in in IN cord-335975-m6lkrehi 434 36 continuous continuous JJ cord-335975-m6lkrehi 434 37 positive positive JJ cord-335975-m6lkrehi 434 38 airway airway NN cord-335975-m6lkrehi 434 39 pressure pressure NN cord-335975-m6lkrehi 434 40 . . . cord-335975-m6lkrehi 435 1 Patients patient NNS cord-335975-m6lkrehi 435 2 and and CC cord-335975-m6lkrehi 435 3 methods method NNS cord-335975-m6lkrehi 435 4 : : : cord-335975-m6lkrehi 435 5 A a DT cord-335975-m6lkrehi 435 6 prospective prospective JJ cord-335975-m6lkrehi 435 7 single single JJ cord-335975-m6lkrehi 435 8 center center NN cord-335975-m6lkrehi 435 9 study study NN cord-335975-m6lkrehi 435 10 . . . cord-335975-m6lkrehi 436 1 All all DT cord-335975-m6lkrehi 436 2 intubated intubate VBN cord-335975-m6lkrehi 436 3 and and CC cord-335975-m6lkrehi 436 4 mechanically mechanically RB cord-335975-m6lkrehi 436 5 ventilated ventilate VBN cord-335975-m6lkrehi 436 6 children child NNS cord-335975-m6lkrehi 436 7 > > XX cord-335975-m6lkrehi 436 8 1 1 CD cord-335975-m6lkrehi 436 9 months month NNS cord-335975-m6lkrehi 436 10 and and CC cord-335975-m6lkrehi 436 11 < < XX cord-335975-m6lkrehi 436 12 18 18 CD cord-335975-m6lkrehi 436 13 years year NNS cord-335975-m6lkrehi 436 14 old old JJ cord-335975-m6lkrehi 436 15 , , , cord-335975-m6lkrehi 436 16 hospitalized hospitalize VBN cord-335975-m6lkrehi 436 17 in in IN cord-335975-m6lkrehi 436 18 the the DT cord-335975-m6lkrehi 436 19 pediatric pediatric JJ cord-335975-m6lkrehi 436 20 intensive intensive JJ cord-335975-m6lkrehi 436 21 care care NN cord-335975-m6lkrehi 436 22 unit unit NN cord-335975-m6lkrehi 436 23 were be VBD cord-335975-m6lkrehi 436 24 eligible eligible JJ cord-335975-m6lkrehi 436 25 . . . cord-335975-m6lkrehi 437 1 Patients patient NNS cord-335975-m6lkrehi 437 2 considered consider VBN cord-335975-m6lkrehi 437 3 as as RB cord-335975-m6lkrehi 437 4 ready ready JJ cord-335975-m6lkrehi 437 5 to to TO cord-335975-m6lkrehi 437 6 extubate extubate NNP cord-335975-m6lkrehi 437 7 were be VBD cord-335975-m6lkrehi 437 8 included include VBN cord-335975-m6lkrehi 437 9 . . . cord-335975-m6lkrehi 438 1 Simultaneous simultaneous JJ cord-335975-m6lkrehi 438 2 recordings recording NNS cord-335975-m6lkrehi 438 3 of of IN cord-335975-m6lkrehi 438 4 VO2 vo2 NN cord-335975-m6lkrehi 438 5 , , , cord-335975-m6lkrehi 438 6 Pes Pes NNP cord-335975-m6lkrehi 438 7 and and CC cord-335975-m6lkrehi 438 8 EAdi EAdi NNP cord-335975-m6lkrehi 438 9 were be VBD cord-335975-m6lkrehi 438 10 performed perform VBN cord-335975-m6lkrehi 438 11 during during IN cord-335975-m6lkrehi 438 12 3 3 CD cord-335975-m6lkrehi 438 13 steps step NNS cord-335975-m6lkrehi 438 14 : : : cord-335975-m6lkrehi 438 15 before before IN cord-335975-m6lkrehi 438 16 , , , cord-335975-m6lkrehi 438 17 during during IN cord-335975-m6lkrehi 438 18 and and CC cord-335975-m6lkrehi 438 19 after after IN cord-335975-m6lkrehi 438 20 the the DT cord-335975-m6lkrehi 438 21 spontaneous spontaneous JJ cord-335975-m6lkrehi 438 22 breathing breathing NN cord-335975-m6lkrehi 438 23 test test NN cord-335975-m6lkrehi 438 24 in in IN cord-335975-m6lkrehi 438 25 continuous continuous JJ cord-335975-m6lkrehi 438 26 positive positive JJ cord-335975-m6lkrehi 438 27 airway airway NN cord-335975-m6lkrehi 438 28 pressure pressure NN cord-335975-m6lkrehi 438 29 . . . cord-335975-m6lkrehi 439 1 Results result NNS cord-335975-m6lkrehi 439 2 : : : cord-335975-m6lkrehi 440 1 Twenty twenty CD cord-335975-m6lkrehi 440 2 patients patient NNS cord-335975-m6lkrehi 440 3 , , , cord-335975-m6lkrehi 440 4 median median JJ cord-335975-m6lkrehi 440 5 5.5 5.5 CD cord-335975-m6lkrehi 440 6 months month NNS cord-335975-m6lkrehi 440 7 , , , cord-335975-m6lkrehi 440 8 were be VBD cord-335975-m6lkrehi 440 9 included include VBN cord-335975-m6lkrehi 440 10 . . . cord-335975-m6lkrehi 441 1 Half half NN cord-335975-m6lkrehi 441 2 of of IN cord-335975-m6lkrehi 441 3 the the DT cord-335975-m6lkrehi 441 4 patients patient NNS cord-335975-m6lkrehi 441 5 were be VBD cord-335975-m6lkrehi 441 6 admitted admit VBN cord-335975-m6lkrehi 441 7 for for IN cord-335975-m6lkrehi 441 8 a a DT cord-335975-m6lkrehi 441 9 respiratory respiratory JJ cord-335975-m6lkrehi 441 10 reason reason NN cord-335975-m6lkrehi 441 11 . . . cord-335975-m6lkrehi 442 1 Predicted predict VBN cord-335975-m6lkrehi 442 2 resting rest VBG cord-335975-m6lkrehi 442 3 energy energy NN cord-335975-m6lkrehi 442 4 expenditure expenditure NN cord-335975-m6lkrehi 442 5 was be VBD cord-335975-m6lkrehi 442 6 overestimated overestimate VBN cord-335975-m6lkrehi 442 7 as as IN cord-335975-m6lkrehi 442 8 compared compare VBN cord-335975-m6lkrehi 442 9 to to IN cord-335975-m6lkrehi 442 10 measured measure VBN cord-335975-m6lkrehi 442 11 resting rest VBG cord-335975-m6lkrehi 442 12 energy energy NN cord-335975-m6lkrehi 442 13 expenditure expenditure NN cord-335975-m6lkrehi 442 14 ( ( -LRB- cord-335975-m6lkrehi 442 15 51 51 CD cord-335975-m6lkrehi 442 16 [ [ -LRB- cord-335975-m6lkrehi 442 17 47 47 CD cord-335975-m6lkrehi 442 18 - - SYM cord-335975-m6lkrehi 442 19 55 55 CD cord-335975-m6lkrehi 442 20 ] ] -RRB- cord-335975-m6lkrehi 442 21 vs vs IN cord-335975-m6lkrehi 442 22 23 23 CD cord-335975-m6lkrehi 442 23 [ [ -LRB- cord-335975-m6lkrehi 442 24 21 21 CD cord-335975-m6lkrehi 442 25 ] ] -RRB- cord-335975-m6lkrehi 443 1 [ [ -LRB- cord-335975-m6lkrehi 443 2 22 22 CD cord-335975-m6lkrehi 443 3 ] ] -RRB- cord-335975-m6lkrehi 443 4 [ [ -LRB- cord-335975-m6lkrehi 443 5 23 23 CD cord-335975-m6lkrehi 443 6 ] ] -RRB- cord-335975-m6lkrehi 444 1 [ [ -LRB- cord-335975-m6lkrehi 444 2 24 24 CD cord-335975-m6lkrehi 444 3 ] ] -RRB- cord-335975-m6lkrehi 444 4 [ [ -LRB- cord-335975-m6lkrehi 444 5 25 25 CD cord-335975-m6lkrehi 444 6 ] ] -RRB- cord-335975-m6lkrehi 444 7 [ [ -LRB- cord-335975-m6lkrehi 444 8 26 26 CD cord-335975-m6lkrehi 444 9 ] ] -RRB- cord-335975-m6lkrehi 444 10 [ [ -LRB- cord-335975-m6lkrehi 444 11 27 27 CD cord-335975-m6lkrehi 444 12 ] ] -RRB- cord-335975-m6lkrehi 445 1 [ [ -LRB- cord-335975-m6lkrehi 445 2 28 28 CD cord-335975-m6lkrehi 445 3 ] ] -RRB- cord-335975-m6lkrehi 445 4 [ [ -LRB- cord-335975-m6lkrehi 445 5 29 29 CD cord-335975-m6lkrehi 445 6 ] ] -RRB- cord-335975-m6lkrehi 445 7 kcal kcal NNP cord-335975-m6lkrehi 445 8 kg kg NNP cord-335975-m6lkrehi 445 9 day day NN cord-335975-m6lkrehi 445 10 , , , cord-335975-m6lkrehi 445 11 p p NN cord-335975-m6lkrehi 445 12 < < XX cord-335975-m6lkrehi 445 13 0.001 0.001 CD cord-335975-m6lkrehi 445 14 ) ) -RRB- cord-335975-m6lkrehi 445 15 . . . cord-335975-m6lkrehi 446 1 Spontaneous spontaneous JJ cord-335975-m6lkrehi 446 2 breathing breathing NN cord-335975-m6lkrehi 446 3 test test NN cord-335975-m6lkrehi 446 4 was be VBD cord-335975-m6lkrehi 446 5 associated associate VBN cord-335975-m6lkrehi 446 6 with with IN cord-335975-m6lkrehi 446 7 an an DT cord-335975-m6lkrehi 446 8 increase increase NN cord-335975-m6lkrehi 446 9 in in IN cord-335975-m6lkrehi 446 10 Esophageal Esophageal NNP cord-335975-m6lkrehi 446 11 Pressure Pressure NNP cord-335975-m6lkrehi 446 12 - - HYPH cord-335975-m6lkrehi 446 13 Time Time NNP cord-335975-m6lkrehi 446 14 Product Product NNP cord-335975-m6lkrehi 446 15 from from IN cord-335975-m6lkrehi 446 16 23 23 CD cord-335975-m6lkrehi 446 17 to to IN cord-335975-m6lkrehi 446 18 83 83 CD cord-335975-m6lkrehi 446 19 cm cm NNS cord-335975-m6lkrehi 447 1 H h NN cord-335975-m6lkrehi 447 2 2 2 CD cord-335975-m6lkrehi 448 1 O o UH cord-335975-m6lkrehi 448 2 s s NN cord-335975-m6lkrehi 448 3 min min NN cord-335975-m6lkrehi 448 4 . . . cord-335975-m6lkrehi 449 1 The the DT cord-335975-m6lkrehi 449 2 same same JJ cord-335975-m6lkrehi 449 3 trend trend NN cord-335975-m6lkrehi 449 4 was be VBD cord-335975-m6lkrehi 449 5 observed observe VBN cord-335975-m6lkrehi 449 6 in in IN cord-335975-m6lkrehi 449 7 respiratory respiratory JJ cord-335975-m6lkrehi 449 8 drive drive NN cord-335975-m6lkrehi 449 9 , , , cord-335975-m6lkrehi 449 10 assessed assess VBN cord-335975-m6lkrehi 449 11 by by IN cord-335975-m6lkrehi 449 12 EAdi EAdi NNP cord-335975-m6lkrehi 449 13 which which WDT cord-335975-m6lkrehi 449 14 increased increase VBD cord-335975-m6lkrehi 449 15 from from IN cord-335975-m6lkrehi 449 16 7.5 7.5 CD cord-335975-m6lkrehi 449 17 [ [ -LRB- cord-335975-m6lkrehi 449 18 3.2 3.2 CD cord-335975-m6lkrehi 449 19 - - HYPH cord-335975-m6lkrehi 449 20 16.3 16.3 CD cord-335975-m6lkrehi 449 21 ] ] -RRB- cord-335975-m6lkrehi 449 22 to to IN cord-335975-m6lkrehi 449 23 15.9 15.9 CD cord-335975-m6lkrehi 449 24 [ [ -LRB- cord-335975-m6lkrehi 449 25 5 5 CD cord-335975-m6lkrehi 449 26 . . CD cord-335975-m6lkrehi 449 27 2 2 CD cord-335975-m6lkrehi 449 28 - - SYM cord-335975-m6lkrehi 449 29 22.1 22.1 CD cord-335975-m6lkrehi 449 30 ] ] -RRB- cord-335975-m6lkrehi 449 31 . . . cord-335975-m6lkrehi 450 1 Oxygen oxygen NN cord-335975-m6lkrehi 450 2 consumption consumption NN cord-335975-m6lkrehi 450 3 obtained obtain VBN cord-335975-m6lkrehi 450 4 by by IN cord-335975-m6lkrehi 450 5 IC IC NNP cord-335975-m6lkrehi 450 6 was be VBD cord-335975-m6lkrehi 450 7 higher high JJR cord-335975-m6lkrehi 450 8 during during IN cord-335975-m6lkrehi 450 9 spontaneous spontaneous JJ cord-335975-m6lkrehi 450 10 breathing breathing NN cord-335975-m6lkrehi 450 11 test test NN cord-335975-m6lkrehi 450 12 as as IN cord-335975-m6lkrehi 450 13 compared compare VBN cord-335975-m6lkrehi 450 14 to to IN cord-335975-m6lkrehi 450 15 conventional conventional JJ cord-335975-m6lkrehi 450 16 ventilation ventilation NN cord-335975-m6lkrehi 450 17 ( ( -LRB- cord-335975-m6lkrehi 450 18 3.8 3.8 CD cord-335975-m6lkrehi 450 19 [ [ -LRB- cord-335975-m6lkrehi 450 20 3.0 3.0 CD cord-335975-m6lkrehi 450 21 - - SYM cord-335975-m6lkrehi 450 22 5.2 5.2 CD cord-335975-m6lkrehi 450 23 ] ] -RRB- cord-335975-m6lkrehi 450 24 vs vs IN cord-335975-m6lkrehi 450 25 3.6 3.6 CD cord-335975-m6lkrehi 450 26 [ [ -LRB- cord-335975-m6lkrehi 450 27 3.1 3.1 CD cord-335975-m6lkrehi 450 28 - - SYM cord-335975-m6lkrehi 450 29 4.6 4.6 CD cord-335975-m6lkrehi 450 30 ] ] -RRB- cord-335975-m6lkrehi 450 31 ml ml NNS cord-335975-m6lkrehi 450 32 kg kg NN cord-335975-m6lkrehi 450 33 min min NNP cord-335975-m6lkrehi 450 34 ) ) -RRB- cord-335975-m6lkrehi 450 35 but but CC cord-335975-m6lkrehi 450 36 non non AFX cord-335975-m6lkrehi 450 37 significantly significantly RB cord-335975-m6lkrehi 450 38 . . . cord-335975-m6lkrehi 451 1 Changes change NNS cord-335975-m6lkrehi 451 2 in in IN cord-335975-m6lkrehi 451 3 work work NN cord-335975-m6lkrehi 451 4 of of IN cord-335975-m6lkrehi 451 5 breathing breathing NN cord-335975-m6lkrehi 451 6 as as IN cord-335975-m6lkrehi 451 7 assessed assess VBN cord-335975-m6lkrehi 451 8 by by IN cord-335975-m6lkrehi 451 9 VO VO NNP cord-335975-m6lkrehi 451 10 2 2 CD cord-335975-m6lkrehi 451 11 was be VBD cord-335975-m6lkrehi 451 12 poorly poorly RB cord-335975-m6lkrehi 451 13 correlated correlate VBN cord-335975-m6lkrehi 451 14 with with IN cord-335975-m6lkrehi 451 15 measurements measurement NNS cord-335975-m6lkrehi 451 16 from from IN cord-335975-m6lkrehi 451 17 Pes Pes NNP cord-335975-m6lkrehi 451 18 and and CC cord-335975-m6lkrehi 451 19 EAdi EAdi NNP cord-335975-m6lkrehi 451 20 whereas whereas IN cord-335975-m6lkrehi 451 21 we -PRON- PRP cord-335975-m6lkrehi 451 22 found find VBD cord-335975-m6lkrehi 451 23 a a DT cord-335975-m6lkrehi 451 24 moderate moderate JJ cord-335975-m6lkrehi 451 25 correlation correlation NN cord-335975-m6lkrehi 451 26 between between IN cord-335975-m6lkrehi 451 27 Pes Pes NNP cord-335975-m6lkrehi 451 28 and and CC cord-335975-m6lkrehi 451 29 EAdi EAdi NNP cord-335975-m6lkrehi 451 30 values value NNS cord-335975-m6lkrehi 451 31 . . . cord-335975-m6lkrehi 452 1 Spontaneous spontaneous JJ cord-335975-m6lkrehi 452 2 breathing breathing NN cord-335975-m6lkrehi 452 3 test test NN cord-335975-m6lkrehi 452 4 and and CC cord-335975-m6lkrehi 452 5 extubation extubation NN cord-335975-m6lkrehi 452 6 were be VBD cord-335975-m6lkrehi 452 7 successful successful JJ cord-335975-m6lkrehi 452 8 in in IN cord-335975-m6lkrehi 452 9 20 20 CD cord-335975-m6lkrehi 452 10 ( ( -LRB- cord-335975-m6lkrehi 452 11 100 100 CD cord-335975-m6lkrehi 452 12 % % NN cord-335975-m6lkrehi 452 13 ) ) -RRB- cord-335975-m6lkrehi 452 14 and and CC cord-335975-m6lkrehi 452 15 18 18 CD cord-335975-m6lkrehi 452 16 ( ( -LRB- cord-335975-m6lkrehi 452 17 90 90 CD cord-335975-m6lkrehi 452 18 % % NN cord-335975-m6lkrehi 452 19 ) ) -RRB- cord-335975-m6lkrehi 452 20 patients patient NNS cord-335975-m6lkrehi 452 21 , , , cord-335975-m6lkrehi 452 22 respectively respectively RB cord-335975-m6lkrehi 452 23 . . . cord-335975-m6lkrehi 453 1 Conclusion conclusion NN cord-335975-m6lkrehi 453 2 : : : cord-335975-m6lkrehi 454 1 During during IN cord-335975-m6lkrehi 454 2 weaning wean VBG cord-335975-m6lkrehi 454 3 from from IN cord-335975-m6lkrehi 454 4 mechanical mechanical JJ cord-335975-m6lkrehi 454 5 ventilation ventilation NN cord-335975-m6lkrehi 454 6 , , , cord-335975-m6lkrehi 454 7 spontaneous spontaneous JJ cord-335975-m6lkrehi 454 8 breathing breathing NN cord-335975-m6lkrehi 454 9 test test NN cord-335975-m6lkrehi 454 10 in in IN cord-335975-m6lkrehi 454 11 continuous continuous JJ cord-335975-m6lkrehi 454 12 positive positive JJ cord-335975-m6lkrehi 454 13 airway airway NN cord-335975-m6lkrehi 454 14 pressure pressure NN cord-335975-m6lkrehi 454 15 induced induce VBD cord-335975-m6lkrehi 454 16 an an DT cord-335975-m6lkrehi 454 17 increase increase NN cord-335975-m6lkrehi 454 18 in in IN cord-335975-m6lkrehi 454 19 work work NN cord-335975-m6lkrehi 454 20 of of IN cord-335975-m6lkrehi 454 21 breathing breathing NN cord-335975-m6lkrehi 454 22 , , , cord-335975-m6lkrehi 454 23 both both CC cord-335975-m6lkrehi 454 24 in in IN cord-335975-m6lkrehi 454 25 respiratory respiratory JJ cord-335975-m6lkrehi 454 26 drive drive NN cord-335975-m6lkrehi 454 27 , , , cord-335975-m6lkrehi 454 28 as as IN cord-335975-m6lkrehi 454 29 measured measure VBN cord-335975-m6lkrehi 454 30 by by IN cord-335975-m6lkrehi 454 31 EAdi EAdi NNP cord-335975-m6lkrehi 454 32 and and CC cord-335975-m6lkrehi 454 33 in in IN cord-335975-m6lkrehi 454 34 respiratory respiratory JJ cord-335975-m6lkrehi 454 35 mechanics mechanic NNS cord-335975-m6lkrehi 454 36 , , , cord-335975-m6lkrehi 454 37 as as IN cord-335975-m6lkrehi 454 38 measured measure VBN cord-335975-m6lkrehi 454 39 by by IN cord-335975-m6lkrehi 454 40 Pes Pes NNP cord-335975-m6lkrehi 454 41 . . . cord-335975-m6lkrehi 455 1 Oxygen oxygen NN cord-335975-m6lkrehi 455 2 consumption consumption NN cord-335975-m6lkrehi 455 3 measured measure VBN cord-335975-m6lkrehi 455 4 by by IN cord-335975-m6lkrehi 455 5 Indirect Indirect NNP cord-335975-m6lkrehi 455 6 Calorimetry Calorimetry NNP cord-335975-m6lkrehi 455 7 does do VBZ cord-335975-m6lkrehi 455 8 not not RB cord-335975-m6lkrehi 455 9 seem seem VB cord-335975-m6lkrehi 455 10 to to TO cord-335975-m6lkrehi 455 11 be be VB cord-335975-m6lkrehi 455 12 a a DT cord-335975-m6lkrehi 455 13 reliable reliable JJ cord-335975-m6lkrehi 455 14 tool tool NN cord-335975-m6lkrehi 455 15 to to TO cord-335975-m6lkrehi 455 16 assess assess VB cord-335975-m6lkrehi 455 17 work work NN cord-335975-m6lkrehi 455 18 of of IN cord-335975-m6lkrehi 455 19 breathing breathing NN cord-335975-m6lkrehi 455 20 in in IN cord-335975-m6lkrehi 455 21 mechanically mechanically RB cord-335975-m6lkrehi 455 22 ventilated ventilate VBN cord-335975-m6lkrehi 455 23 children child NNS cord-335975-m6lkrehi 455 24 . . . cord-335975-m6lkrehi 456 1 Ben Ben NNP cord-335975-m6lkrehi 456 2 Gheriba Gheriba NNP cord-335975-m6lkrehi 456 3 Khalil Khalil NNP cord-335975-m6lkrehi 456 4 1 1 CD cord-335975-m6lkrehi 456 5 , , , cord-335975-m6lkrehi 456 6 Grimaud Grimaud NNP cord-335975-m6lkrehi 456 7 Marion Marion NNP cord-335975-m6lkrehi 456 8 1 1 CD cord-335975-m6lkrehi 456 9 , , , cord-335975-m6lkrehi 456 10 Heilbronner Heilbronner NNP cord-335975-m6lkrehi 456 11 Claire Claire NNP cord-335975-m6lkrehi 456 12 1 1 CD cord-335975-m6lkrehi 456 13 , , , cord-335975-m6lkrehi 456 14 Roy Roy NNP cord-335975-m6lkrehi 456 15 Emeline Emeline NNP cord-335975-m6lkrehi 456 16 1 1 CD cord-335975-m6lkrehi 456 17 , , , cord-335975-m6lkrehi 456 18 Hadchouel Hadchouel NNP cord-335975-m6lkrehi 456 19 Alice Alice NNP cord-335975-m6lkrehi 456 20 1 1 CD cord-335975-m6lkrehi 456 21 , , , cord-335975-m6lkrehi 456 22 Renolleau Renolleau NNP cord-335975-m6lkrehi 456 23 Sylvain Sylvain NNP cord-335975-m6lkrehi 456 24 1 1 CD cord-335975-m6lkrehi 456 25 , , , cord-335975-m6lkrehi 456 26 Rigourd Rigourd NNP cord-335975-m6lkrehi 456 27 Virginie Virginie NNP cord-335975-m6lkrehi 456 28 1 1 CD cord-335975-m6lkrehi 456 29 1 1 CD cord-335975-m6lkrehi 456 30 Hôpital Hôpital NNP cord-335975-m6lkrehi 456 31 Necker Necker NNP cord-335975-m6lkrehi 456 32 Enfants Enfants NNP cord-335975-m6lkrehi 456 33 Malades Malades NNP cord-335975-m6lkrehi 456 34 , , , cord-335975-m6lkrehi 456 35 Paris Paris NNP cord-335975-m6lkrehi 457 1 , , , cord-335975-m6lkrehi 457 2 France France NNP cord-335975-m6lkrehi 457 3 Correspondence Correspondence NNP cord-335975-m6lkrehi 457 4 : : : cord-335975-m6lkrehi 457 5 Ben Ben NNP cord-335975-m6lkrehi 457 6 Gheriba Gheriba NNP cord-335975-m6lkrehi 457 7 Khalil Khalil NNP cord-335975-m6lkrehi 457 8 -bg.khalil@gmail.com -bg.khalil@gmail.com HYPH cord-335975-m6lkrehi 457 9 Annals Annals NNP cord-335975-m6lkrehi 457 10 of of IN cord-335975-m6lkrehi 457 11 Intensive Intensive NNP cord-335975-m6lkrehi 457 12 Care Care NNP cord-335975-m6lkrehi 457 13 2018 2018 CD cord-335975-m6lkrehi 457 14 , , , cord-335975-m6lkrehi 457 15 8(Suppl 8(suppl CD cord-335975-m6lkrehi 457 16 1 1 CD cord-335975-m6lkrehi 457 17 ) ) -RRB- cord-335975-m6lkrehi 457 18 : : : cord-335975-m6lkrehi 458 1 Introduction introduction NN cord-335975-m6lkrehi 458 2 : : : cord-335975-m6lkrehi 458 3 During during IN cord-335975-m6lkrehi 458 4 the the DT cord-335975-m6lkrehi 458 5 winter winter NN cord-335975-m6lkrehi 458 6 season season NN cord-335975-m6lkrehi 458 7 2015 2015 CD cord-335975-m6lkrehi 458 8 - - SYM cord-335975-m6lkrehi 458 9 2016 2016 CD cord-335975-m6lkrehi 458 10 we -PRON- PRP cord-335975-m6lkrehi 458 11 had have VBD cord-335975-m6lkrehi 458 12 evaluated evaluate VBN cord-335975-m6lkrehi 458 13 breastfeeding breastfeed VBG cord-335975-m6lkrehi 458 14 disruption disruption NN cord-335975-m6lkrehi 458 15 after after IN cord-335975-m6lkrehi 458 16 hospitalization hospitalization NN cord-335975-m6lkrehi 458 17 for for IN cord-335975-m6lkrehi 458 18 bronchiolitis bronchiolitis NN cord-335975-m6lkrehi 458 19 in in IN cord-335975-m6lkrehi 458 20 our -PRON- PRP$ cord-335975-m6lkrehi 458 21 hospital hospital NN cord-335975-m6lkrehi 458 22 in in IN cord-335975-m6lkrehi 458 23 infants infant NNS cord-335975-m6lkrehi 458 24 under under IN cord-335975-m6lkrehi 458 25 6 6 CD cord-335975-m6lkrehi 458 26 month month NN cord-335975-m6lkrehi 458 27 ( ( -LRB- cord-335975-m6lkrehi 458 28 n n NN cord-335975-m6lkrehi 458 29 = = SYM cord-335975-m6lkrehi 458 30 84 84 CD cord-335975-m6lkrehi 458 31 ) ) -RRB- cord-335975-m6lkrehi 458 32 . . . cord-335975-m6lkrehi 459 1 We -PRON- PRP cord-335975-m6lkrehi 459 2 observed observe VBD cord-335975-m6lkrehi 459 3 51 51 CD cord-335975-m6lkrehi 459 4 % % NN cord-335975-m6lkrehi 459 5 of of IN cord-335975-m6lkrehi 459 6 mothers mother NNS cord-335975-m6lkrehi 459 7 whose whose WP$ cord-335975-m6lkrehi 459 8 breastfeeding breastfeeding NN cord-335975-m6lkrehi 459 9 was be VBD cord-335975-m6lkrehi 459 10 stopped stop VBN cord-335975-m6lkrehi 459 11 of of IN cord-335975-m6lkrehi 459 12 modified modify VBN cord-335975-m6lkrehi 459 13 . . . cord-335975-m6lkrehi 460 1 Clinical clinical JJ cord-335975-m6lkrehi 460 2 severity severity NN cord-335975-m6lkrehi 460 3 had have VBD cord-335975-m6lkrehi 460 4 no no DT cord-335975-m6lkrehi 460 5 impact impact NN cord-335975-m6lkrehi 460 6 on on IN cord-335975-m6lkrehi 460 7 breastfeeding breastfeeding NN cord-335975-m6lkrehi 460 8 but but CC cord-335975-m6lkrehi 460 9 63 63 CD cord-335975-m6lkrehi 460 10 % % NN cord-335975-m6lkrehi 460 11 of of IN cord-335975-m6lkrehi 460 12 mothers mother NNS cord-335975-m6lkrehi 460 13 stated state VBD cord-335975-m6lkrehi 460 14 that that IN cord-335975-m6lkrehi 460 15 lack lack NN cord-335975-m6lkrehi 460 16 of of IN cord-335975-m6lkrehi 460 17 support support NN cord-335975-m6lkrehi 460 18 and and CC cord-335975-m6lkrehi 460 19 advice advice NN cord-335975-m6lkrehi 460 20 was be VBD cord-335975-m6lkrehi 460 21 the the DT cord-335975-m6lkrehi 460 22 first first JJ cord-335975-m6lkrehi 460 23 cause cause NN cord-335975-m6lkrehi 460 24 of of IN cord-335975-m6lkrehi 460 25 breastfeeding breastfeed VBG cord-335975-m6lkrehi 460 26 disturbance disturbance NN cord-335975-m6lkrehi 460 27 . . . cord-335975-m6lkrehi 461 1 We -PRON- PRP cord-335975-m6lkrehi 461 2 conducted conduct VBD cord-335975-m6lkrehi 461 3 this this DT cord-335975-m6lkrehi 461 4 second second JJ cord-335975-m6lkrehi 461 5 phase phase NN cord-335975-m6lkrehi 461 6 to to TO cord-335975-m6lkrehi 461 7 evaluate evaluate VB cord-335975-m6lkrehi 461 8 the the DT cord-335975-m6lkrehi 461 9 potential potential JJ cord-335975-m6lkrehi 461 10 impact impact NN cord-335975-m6lkrehi 461 11 of of IN cord-335975-m6lkrehi 461 12 actions action NNS cord-335975-m6lkrehi 461 13 to to TO cord-335975-m6lkrehi 461 14 promote promote VB cord-335975-m6lkrehi 461 15 breastfeeding breastfeeding NN cord-335975-m6lkrehi 461 16 on on IN cord-335975-m6lkrehi 461 17 unwanted unwanted JJ cord-335975-m6lkrehi 461 18 weaning weaning NN cord-335975-m6lkrehi 461 19 during during IN cord-335975-m6lkrehi 461 20 hospitalization hospitalization NN cord-335975-m6lkrehi 461 21 for for IN cord-335975-m6lkrehi 461 22 bronchiolitis bronchiolitis NN cord-335975-m6lkrehi 461 23 . . . cord-335975-m6lkrehi 462 1 Patients patient NNS cord-335975-m6lkrehi 462 2 and and CC cord-335975-m6lkrehi 462 3 methods method NNS cord-335975-m6lkrehi 463 1 : : : cord-335975-m6lkrehi 463 2 This this DT cord-335975-m6lkrehi 463 3 is be VBZ cord-335975-m6lkrehi 463 4 a a DT cord-335975-m6lkrehi 463 5 cross cross JJ cord-335975-m6lkrehi 463 6 sectional sectional JJ cord-335975-m6lkrehi 463 7 study study NN cord-335975-m6lkrehi 463 8 during during IN cord-335975-m6lkrehi 463 9 two two CD cord-335975-m6lkrehi 463 10 epidemic epidemic NN cord-335975-m6lkrehi 463 11 seasons season NNS cord-335975-m6lkrehi 463 12 of of IN cord-335975-m6lkrehi 463 13 bronchiolitis bronchiolitis NN cord-335975-m6lkrehi 463 14 in in IN cord-335975-m6lkrehi 463 15 a a DT cord-335975-m6lkrehi 463 16 tertiary tertiary JJ cord-335975-m6lkrehi 463 17 care care NN cord-335975-m6lkrehi 463 18 hospital hospital NN cord-335975-m6lkrehi 463 19 . . . cord-335975-m6lkrehi 464 1 All all DT cord-335975-m6lkrehi 464 2 patients patient NNS cord-335975-m6lkrehi 464 3 aged age VBN cord-335975-m6lkrehi 464 4 6 6 CD cord-335975-m6lkrehi 464 5 months month NNS cord-335975-m6lkrehi 464 6 or or CC cord-335975-m6lkrehi 464 7 younger young JJR cord-335975-m6lkrehi 464 8 hospitalized hospitalize VBN cord-335975-m6lkrehi 464 9 with with IN cord-335975-m6lkrehi 464 10 acute acute JJ cord-335975-m6lkrehi 464 11 bronchiolitis bronchiolitis NN cord-335975-m6lkrehi 464 12 and and CC cord-335975-m6lkrehi 464 13 receiving receive VBG cord-335975-m6lkrehi 464 14 at at IN cord-335975-m6lkrehi 464 15 least least JJS cord-335975-m6lkrehi 464 16 partial partial JJ cord-335975-m6lkrehi 464 17 breastfeeding breastfeeding NN cord-335975-m6lkrehi 464 18 were be VBD cord-335975-m6lkrehi 464 19 eligible eligible JJ cord-335975-m6lkrehi 464 20 for for IN cord-335975-m6lkrehi 464 21 the the DT cord-335975-m6lkrehi 464 22 study study NN cord-335975-m6lkrehi 464 23 . . . cord-335975-m6lkrehi 465 1 Patients patient NNS cord-335975-m6lkrehi 465 2 discharged discharge VBN cord-335975-m6lkrehi 465 3 at at IN cord-335975-m6lkrehi 465 4 home home NN cord-335975-m6lkrehi 465 5 whose whose WP$ cord-335975-m6lkrehi 465 6 parents parent NNS cord-335975-m6lkrehi 465 7 accepted accept VBD cord-335975-m6lkrehi 465 8 to to TO cord-335975-m6lkrehi 465 9 be be VB cord-335975-m6lkrehi 465 10 contacted contact VBN cord-335975-m6lkrehi 465 11 by by IN cord-335975-m6lkrehi 465 12 phone phone NN cord-335975-m6lkrehi 465 13 were be VBD cord-335975-m6lkrehi 465 14 included include VBN cord-335975-m6lkrehi 465 15 . . . cord-335975-m6lkrehi 466 1 A a DT cord-335975-m6lkrehi 466 2 bundle bundle NN cord-335975-m6lkrehi 466 3 of of IN cord-335975-m6lkrehi 466 4 actions action NNS cord-335975-m6lkrehi 466 5 to to TO cord-335975-m6lkrehi 466 6 promote promote VB cord-335975-m6lkrehi 466 7 breastfeeding breastfeeding NN cord-335975-m6lkrehi 466 8 in in IN cord-335975-m6lkrehi 466 9 patients patient NNS cord-335975-m6lkrehi 466 10 with with IN cord-335975-m6lkrehi 466 11 bronchiolitis bronchiolitis NN cord-335975-m6lkrehi 466 12 was be VBD cord-335975-m6lkrehi 466 13 implemented implement VBN cord-335975-m6lkrehi 466 14 ( ( -LRB- cord-335975-m6lkrehi 466 15 posters poster NNS cord-335975-m6lkrehi 466 16 , , , cord-335975-m6lkrehi 466 17 flyers flyer NNS cord-335975-m6lkrehi 466 18 , , , cord-335975-m6lkrehi 466 19 staff staff NN cord-335975-m6lkrehi 466 20 training training NN cord-335975-m6lkrehi 466 21 , , , cord-335975-m6lkrehi 466 22 equipment equipment NN cord-335975-m6lkrehi 466 23 with with IN cord-335975-m6lkrehi 466 24 breast breast NN cord-335975-m6lkrehi 466 25 pumps pump NNS cord-335975-m6lkrehi 466 26 ) ) -RRB- cord-335975-m6lkrehi 466 27 between between IN cord-335975-m6lkrehi 466 28 the the DT cord-335975-m6lkrehi 466 29 two two CD cord-335975-m6lkrehi 466 30 epidemic epidemic NN cord-335975-m6lkrehi 466 31 seasons season NNS cord-335975-m6lkrehi 466 32 . . . cord-335975-m6lkrehi 467 1 The the DT cord-335975-m6lkrehi 467 2 data datum NNS cord-335975-m6lkrehi 467 3 was be VBD cord-335975-m6lkrehi 467 4 extracted extract VBN cord-335975-m6lkrehi 467 5 from from IN cord-335975-m6lkrehi 467 6 the the DT cord-335975-m6lkrehi 467 7 charts chart NNS cord-335975-m6lkrehi 467 8 and and CC cord-335975-m6lkrehi 467 9 from from IN cord-335975-m6lkrehi 467 10 a a DT cord-335975-m6lkrehi 467 11 phone phone NN cord-335975-m6lkrehi 467 12 survey survey NN cord-335975-m6lkrehi 467 13 two two CD cord-335975-m6lkrehi 467 14 weeks week NNS cord-335975-m6lkrehi 467 15 after after IN cord-335975-m6lkrehi 467 16 discharge discharge NN cord-335975-m6lkrehi 467 17 to to TO cord-335975-m6lkrehi 467 18 evaluate evaluate VB cord-335975-m6lkrehi 467 19 breastfeeding breastfeeding NN cord-335975-m6lkrehi 467 20 in in IN cord-335975-m6lkrehi 467 21 eligible eligible JJ cord-335975-m6lkrehi 467 22 patients patient NNS cord-335975-m6lkrehi 467 23 in in IN cord-335975-m6lkrehi 467 24 our -PRON- PRP$ cord-335975-m6lkrehi 467 25 hospital hospital NN cord-335975-m6lkrehi 467 26 . . . cord-335975-m6lkrehi 468 1 Phase phase NN cord-335975-m6lkrehi 468 2 I -PRON- PRP cord-335975-m6lkrehi 468 3 ( ( -LRB- cord-335975-m6lkrehi 468 4 before before IN cord-335975-m6lkrehi 468 5 action action NN cord-335975-m6lkrehi 468 6 ) ) -RRB- cord-335975-m6lkrehi 468 7 had have VBD cord-335975-m6lkrehi 468 8 included include VBN cord-335975-m6lkrehi 468 9 84 84 CD cord-335975-m6lkrehi 468 10 patients patient NNS cord-335975-m6lkrehi 468 11 hospitalized hospitalize VBN cord-335975-m6lkrehi 468 12 between between IN cord-335975-m6lkrehi 468 13 December December NNP cord-335975-m6lkrehi 468 14 2015 2015 CD cord-335975-m6lkrehi 468 15 and and CC cord-335975-m6lkrehi 468 16 March March NNP cord-335975-m6lkrehi 468 17 2016 2016 CD cord-335975-m6lkrehi 468 18 in in IN cord-335975-m6lkrehi 468 19 all all DT cord-335975-m6lkrehi 468 20 wards ward NNS cord-335975-m6lkrehi 468 21 hosting host VBG cord-335975-m6lkrehi 468 22 patients patient NNS cord-335975-m6lkrehi 468 23 with with IN cord-335975-m6lkrehi 468 24 bronchiolitis bronchiolitis NN cord-335975-m6lkrehi 468 25 . . . cord-335975-m6lkrehi 469 1 Phase phase NN cord-335975-m6lkrehi 469 2 II ii CD cord-335975-m6lkrehi 469 3 ( ( -LRB- cord-335975-m6lkrehi 469 4 after after IN cord-335975-m6lkrehi 469 5 action action NN cord-335975-m6lkrehi 469 6 ) ) -RRB- cord-335975-m6lkrehi 469 7 included include VBD cord-335975-m6lkrehi 469 8 50 50 CD cord-335975-m6lkrehi 469 9 patients patient NNS cord-335975-m6lkrehi 469 10 hospitalized hospitalize VBN cord-335975-m6lkrehi 469 11 from from IN cord-335975-m6lkrehi 469 12 October October NNP cord-335975-m6lkrehi 469 13 2016 2016 CD cord-335975-m6lkrehi 469 14 to to IN cord-335975-m6lkrehi 469 15 December December NNP cord-335975-m6lkrehi 469 16 2016 2016 CD cord-335975-m6lkrehi 469 17 . . . cord-335975-m6lkrehi 470 1 The the DT cord-335975-m6lkrehi 470 2 data datum NNS cord-335975-m6lkrehi 470 3 from from IN cord-335975-m6lkrehi 470 4 phase phase NN cord-335975-m6lkrehi 470 5 II II NNP cord-335975-m6lkrehi 470 6 was be VBD cord-335975-m6lkrehi 470 7 compared compare VBN cord-335975-m6lkrehi 470 8 with with IN cord-335975-m6lkrehi 470 9 data datum NNS cord-335975-m6lkrehi 470 10 from from IN cord-335975-m6lkrehi 470 11 phase phase NN cord-335975-m6lkrehi 470 12 I. i. NN cord-335975-m6lkrehi 470 13 Results result NNS cord-335975-m6lkrehi 470 14 : : : cord-335975-m6lkrehi 471 1 Fifty fifty CD cord-335975-m6lkrehi 471 2 patients patient NNS cord-335975-m6lkrehi 471 3 could could MD cord-335975-m6lkrehi 471 4 be be VB cord-335975-m6lkrehi 471 5 included include VBN cord-335975-m6lkrehi 471 6 during during IN cord-335975-m6lkrehi 471 7 the the DT cord-335975-m6lkrehi 471 8 second second JJ cord-335975-m6lkrehi 471 9 step step NN cord-335975-m6lkrehi 471 10 of of IN cord-335975-m6lkrehi 471 11 the the DT cord-335975-m6lkrehi 471 12 study study NN cord-335975-m6lkrehi 471 13 , , , cord-335975-m6lkrehi 471 14 with with IN cord-335975-m6lkrehi 471 15 a a DT cord-335975-m6lkrehi 471 16 mean mean JJ cord-335975-m6lkrehi 471 17 age age NN cord-335975-m6lkrehi 471 18 of of IN cord-335975-m6lkrehi 471 19 37 37 CD cord-335975-m6lkrehi 471 20 days day NNS cord-335975-m6lkrehi 471 21 . . . cord-335975-m6lkrehi 472 1 Breastfeeding breastfeeding NN cord-335975-m6lkrehi 472 2 was be VBD cord-335975-m6lkrehi 472 3 exclusive exclusive JJ cord-335975-m6lkrehi 472 4 for for IN cord-335975-m6lkrehi 472 5 78 78 CD cord-335975-m6lkrehi 472 6 % % NN cord-335975-m6lkrehi 472 7 of of IN cord-335975-m6lkrehi 472 8 mothers mother NNS cord-335975-m6lkrehi 472 9 ( ( -LRB- cord-335975-m6lkrehi 472 10 vs vs IN cord-335975-m6lkrehi 472 11 77 77 CD cord-335975-m6lkrehi 472 12 % % NN cord-335975-m6lkrehi 472 13 in in IN cord-335975-m6lkrehi 472 14 phase phase NN cord-335975-m6lkrehi 472 15 I i NN cord-335975-m6lkrehi 472 16 ) ) -RRB- cord-335975-m6lkrehi 472 17 . . . cord-335975-m6lkrehi 473 1 The the DT cord-335975-m6lkrehi 473 2 median median JJ cord-335975-m6lkrehi 473 3 length length NN cord-335975-m6lkrehi 473 4 of of IN cord-335975-m6lkrehi 473 5 stay stay NN cord-335975-m6lkrehi 473 6 was be VBD cord-335975-m6lkrehi 473 7 6 6 CD cord-335975-m6lkrehi 473 8 days day NNS cord-335975-m6lkrehi 473 9 ( ( -LRB- cord-335975-m6lkrehi 473 10 vs vs IN cord-335975-m6lkrehi 473 11 3 3 CD cord-335975-m6lkrehi 473 12 days day NNS cord-335975-m6lkrehi 473 13 in in IN cord-335975-m6lkrehi 473 14 phase phase NN cord-335975-m6lkrehi 473 15 I i NN cord-335975-m6lkrehi 473 16 ) ) -RRB- cord-335975-m6lkrehi 473 17 . . . cord-335975-m6lkrehi 474 1 Twenty twenty CD cord-335975-m6lkrehi 474 2 - - HYPH cord-335975-m6lkrehi 474 3 one one CD cord-335975-m6lkrehi 474 4 ( ( -LRB- cord-335975-m6lkrehi 474 5 42 42 CD cord-335975-m6lkrehi 474 6 % % NN cord-335975-m6lkrehi 474 7 ) ) -RRB- cord-335975-m6lkrehi 474 8 patients patient NNS cord-335975-m6lkrehi 474 9 spent spend VBD cord-335975-m6lkrehi 474 10 time time NN cord-335975-m6lkrehi 474 11 in in IN cord-335975-m6lkrehi 474 12 PICU PICU NNP cord-335975-m6lkrehi 474 13 vs. vs. CC cord-335975-m6lkrehi 474 14 32 32 CD cord-335975-m6lkrehi 474 15 % % NN cord-335975-m6lkrehi 474 16 in in IN cord-335975-m6lkrehi 474 17 phase phase NN cord-335975-m6lkrehi 475 1 I -PRON- PRP cord-335975-m6lkrehi 475 2 , , , cord-335975-m6lkrehi 475 3 3 3 CD cord-335975-m6lkrehi 475 4 21 21 CD cord-335975-m6lkrehi 475 5 needed need VBN cord-335975-m6lkrehi 475 6 intubation intubation NN cord-335975-m6lkrehi 475 7 , , , cord-335975-m6lkrehi 475 8 18 18 CD cord-335975-m6lkrehi 475 9 21 21 CD cord-335975-m6lkrehi 475 10 received receive VBN cord-335975-m6lkrehi 475 11 non non JJ cord-335975-m6lkrehi 475 12 invasive invasive JJ cord-335975-m6lkrehi 475 13 ventilation ventilation NN cord-335975-m6lkrehi 475 14 for for IN cord-335975-m6lkrehi 475 15 a a DT cord-335975-m6lkrehi 475 16 median median JJ cord-335975-m6lkrehi 475 17 length length NN cord-335975-m6lkrehi 475 18 of of IN cord-335975-m6lkrehi 475 19 4 4 CD cord-335975-m6lkrehi 475 20 days day NNS cord-335975-m6lkrehi 475 21 ( ( -LRB- cord-335975-m6lkrehi 475 22 vs. vs. NN cord-335975-m6lkrehi 475 23 3 3 CD cord-335975-m6lkrehi 475 24 days day NNS cord-335975-m6lkrehi 475 25 in in IN cord-335975-m6lkrehi 475 26 phase phase NN cord-335975-m6lkrehi 475 27 I i NN cord-335975-m6lkrehi 475 28 ) ) -RRB- cord-335975-m6lkrehi 475 29 . . . cord-335975-m6lkrehi 476 1 The the DT cord-335975-m6lkrehi 476 2 number number NN cord-335975-m6lkrehi 476 3 of of IN cord-335975-m6lkrehi 476 4 patients patient NNS cord-335975-m6lkrehi 476 5 needing need VBG cord-335975-m6lkrehi 476 6 nutritional nutritional JJ cord-335975-m6lkrehi 476 7 support support NN cord-335975-m6lkrehi 476 8 was be VBD cord-335975-m6lkrehi 476 9 35 35 CD cord-335975-m6lkrehi 476 10 50 50 CD cord-335975-m6lkrehi 476 11 ( ( -LRB- cord-335975-m6lkrehi 476 12 70 70 CD cord-335975-m6lkrehi 476 13 % % NN cord-335975-m6lkrehi 476 14 ) ) -RRB- cord-335975-m6lkrehi 476 15 during during IN cord-335975-m6lkrehi 476 16 phase phase NN cord-335975-m6lkrehi 476 17 II II NNP cord-335975-m6lkrehi 476 18 vs. vs. IN cord-335975-m6lkrehi 476 19 44 44 CD cord-335975-m6lkrehi 476 20 84(52 84(52 CD cord-335975-m6lkrehi 476 21 % % NN cord-335975-m6lkrehi 476 22 ) ) -RRB- cord-335975-m6lkrehi 476 23 during during IN cord-335975-m6lkrehi 476 24 phase phase NN cord-335975-m6lkrehi 476 25 I. i. NN cord-335975-m6lkrehi 477 1 After after IN cord-335975-m6lkrehi 477 2 implementation implementation NN cord-335975-m6lkrehi 477 3 of of IN cord-335975-m6lkrehi 477 4 our -PRON- PRP$ cord-335975-m6lkrehi 477 5 actions action NNS cord-335975-m6lkrehi 477 6 , , , cord-335975-m6lkrehi 477 7 40 40 CD cord-335975-m6lkrehi 477 8 50 50 CD cord-335975-m6lkrehi 477 9 ( ( -LRB- cord-335975-m6lkrehi 477 10 81 81 CD cord-335975-m6lkrehi 477 11 % % NN cord-335975-m6lkrehi 477 12 ) ) -RRB- cord-335975-m6lkrehi 477 13 mothers mother NNS cord-335975-m6lkrehi 477 14 kept keep VBD cord-335975-m6lkrehi 477 15 breastfeeding breastfeed VBG cord-335975-m6lkrehi 477 16 as as IN cord-335975-m6lkrehi 477 17 before before IN cord-335975-m6lkrehi 477 18 ( ( -LRB- cord-335975-m6lkrehi 477 19 vs. vs. NN cord-335975-m6lkrehi 477 20 49 49 CD cord-335975-m6lkrehi 477 21 % % NN cord-335975-m6lkrehi 477 22 in in IN cord-335975-m6lkrehi 477 23 the the DT cord-335975-m6lkrehi 477 24 previous previous JJ cord-335975-m6lkrehi 477 25 epidemic epidemic NN cord-335975-m6lkrehi 477 26 season season NN cord-335975-m6lkrehi 477 27 , , , cord-335975-m6lkrehi 477 28 p p NN cord-335975-m6lkrehi 477 29 < < XX cord-335975-m6lkrehi 477 30 0.05 0.05 CD cord-335975-m6lkrehi 477 31 ) ) -RRB- cord-335975-m6lkrehi 477 32 , , , cord-335975-m6lkrehi 477 33 4 4 CD cord-335975-m6lkrehi 477 34 mothers mother NNS cord-335975-m6lkrehi 477 35 ( ( -LRB- cord-335975-m6lkrehi 477 36 8 8 CD cord-335975-m6lkrehi 477 37 % % NN cord-335975-m6lkrehi 477 38 ) ) -RRB- cord-335975-m6lkrehi 477 39 stopped stop VBD cord-335975-m6lkrehi 477 40 , , , cord-335975-m6lkrehi 477 41 4 4 CD cord-335975-m6lkrehi 477 42 ( ( -LRB- cord-335975-m6lkrehi 477 43 8 8 CD cord-335975-m6lkrehi 477 44 % % NN cord-335975-m6lkrehi 477 45 ) ) -RRB- cord-335975-m6lkrehi 477 46 switched switch VBD cord-335975-m6lkrehi 477 47 to to IN cord-335975-m6lkrehi 477 48 partial partial JJ cord-335975-m6lkrehi 477 49 breastfeeding breastfeeding NN cord-335975-m6lkrehi 477 50 and and CC cord-335975-m6lkrehi 477 51 2 2 CD cord-335975-m6lkrehi 477 52 ( ( -LRB- cord-335975-m6lkrehi 477 53 4 4 CD cord-335975-m6lkrehi 477 54 % % NN cord-335975-m6lkrehi 477 55 ) ) -RRB- cord-335975-m6lkrehi 477 56 reduced reduce VBN cord-335975-m6lkrehi 477 57 without without IN cord-335975-m6lkrehi 477 58 stopping stop VBG cord-335975-m6lkrehi 477 59 . . . cord-335975-m6lkrehi 478 1 Conclusion conclusion NN cord-335975-m6lkrehi 478 2 : : : cord-335975-m6lkrehi 479 1 Bronchiolitis Bronchiolitis NNP cord-335975-m6lkrehi 479 2 is be VBZ cord-335975-m6lkrehi 479 3 a a DT cord-335975-m6lkrehi 479 4 high high JJ cord-335975-m6lkrehi 479 5 risk risk NN cord-335975-m6lkrehi 479 6 event event NN cord-335975-m6lkrehi 479 7 for for IN cord-335975-m6lkrehi 479 8 breastfeeding breastfeed VBG cord-335975-m6lkrehi 479 9 disruption disruption NN cord-335975-m6lkrehi 479 10 but but CC cord-335975-m6lkrehi 479 11 staff staff NN cord-335975-m6lkrehi 479 12 training training NN cord-335975-m6lkrehi 479 13 and and CC cord-335975-m6lkrehi 479 14 correct correct JJ cord-335975-m6lkrehi 479 15 advices advice NNS cord-335975-m6lkrehi 479 16 and and CC cord-335975-m6lkrehi 479 17 support support NN cord-335975-m6lkrehi 479 18 for for IN cord-335975-m6lkrehi 479 19 mothers mother NNS cord-335975-m6lkrehi 479 20 during during IN cord-335975-m6lkrehi 479 21 hospitalization hospitalization NN cord-335975-m6lkrehi 479 22 seems seem VBZ cord-335975-m6lkrehi 479 23 to to TO cord-335975-m6lkrehi 479 24 diminish diminish VB cord-335975-m6lkrehi 479 25 that that DT cord-335975-m6lkrehi 479 26 risk risk NN cord-335975-m6lkrehi 479 27 . . . cord-335975-m6lkrehi 480 1 Benefits benefit NNS cord-335975-m6lkrehi 480 2 of of IN cord-335975-m6lkrehi 480 3 using use VBG cord-335975-m6lkrehi 480 4 a a DT cord-335975-m6lkrehi 480 5 high high JJ cord-335975-m6lkrehi 480 6 temporal temporal JJ cord-335975-m6lkrehi 480 7 resolution resolution NN cord-335975-m6lkrehi 480 8 database database NN cord-335975-m6lkrehi 480 9 in in IN cord-335975-m6lkrehi 480 10 the the DT cord-335975-m6lkrehi 480 11 automatic automatic JJ cord-335975-m6lkrehi 480 12 real real JJ cord-335975-m6lkrehi 480 13 - - HYPH cord-335975-m6lkrehi 480 14 time time NN cord-335975-m6lkrehi 480 15 pediatric pediatric JJ cord-335975-m6lkrehi 480 16 ARDS ARDS NNP cord-335975-m6lkrehi 480 17 screening screen VBG cord-335975-m6lkrehi 480 18 Nardi Nardi NNP cord-335975-m6lkrehi 480 19 Nicolas Nicolas NNP cord-335975-m6lkrehi 480 20 1 1 CD cord-335975-m6lkrehi 480 21 Introduction introduction NN cord-335975-m6lkrehi 480 22 : : : cord-335975-m6lkrehi 480 23 Pediatric pediatric JJ cord-335975-m6lkrehi 480 24 acute acute JJ cord-335975-m6lkrehi 480 25 respiratory respiratory JJ cord-335975-m6lkrehi 480 26 distress distress NN cord-335975-m6lkrehi 480 27 syndrome syndrome NN cord-335975-m6lkrehi 480 28 ( ( -LRB- cord-335975-m6lkrehi 480 29 PARDS PARDS NNP cord-335975-m6lkrehi 480 30 ) ) -RRB- cord-335975-m6lkrehi 480 31 is be VBZ cord-335975-m6lkrehi 480 32 frequent frequent JJ cord-335975-m6lkrehi 480 33 in in IN cord-335975-m6lkrehi 480 34 pediatric pediatric JJ cord-335975-m6lkrehi 480 35 intensive intensive JJ cord-335975-m6lkrehi 480 36 care care NN cord-335975-m6lkrehi 480 37 units unit NNS cord-335975-m6lkrehi 480 38 ( ( -LRB- cord-335975-m6lkrehi 480 39 PICU PICU NNP cord-335975-m6lkrehi 480 40 ) ) -RRB- cord-335975-m6lkrehi 480 41 , , , cord-335975-m6lkrehi 480 42 potentially potentially RB cord-335975-m6lkrehi 480 43 lethal lethal JJ cord-335975-m6lkrehi 480 44 and and CC cord-335975-m6lkrehi 480 45 the the DT cord-335975-m6lkrehi 480 46 diagnosis diagnosis NN cord-335975-m6lkrehi 480 47 is be VBZ cord-335975-m6lkrehi 480 48 often often RB cord-335975-m6lkrehi 480 49 missed miss VBN cord-335975-m6lkrehi 480 50 or or CC cord-335975-m6lkrehi 480 51 delayed delay VBN cord-335975-m6lkrehi 480 52 ( ( -LRB- cord-335975-m6lkrehi 480 53 PALICC PALICC NNP cord-335975-m6lkrehi 480 54 2015 2015 CD cord-335975-m6lkrehi 480 55 ) ) -RRB- cord-335975-m6lkrehi 480 56 . . . cord-335975-m6lkrehi 481 1 In in IN cord-335975-m6lkrehi 481 2 PICU PICU NNP cord-335975-m6lkrehi 481 3 , , , cord-335975-m6lkrehi 481 4 data datum NNS cord-335975-m6lkrehi 481 5 are be VBP cord-335975-m6lkrehi 481 6 usually usually RB cord-335975-m6lkrehi 481 7 recorded record VBN cord-335975-m6lkrehi 481 8 between between IN cord-335975-m6lkrehi 481 9 5 5 CD cord-335975-m6lkrehi 481 10 to to TO cord-335975-m6lkrehi 481 11 60 60 CD cord-335975-m6lkrehi 481 12 min min NN cord-335975-m6lkrehi 481 13 which which WDT cord-335975-m6lkrehi 481 14 leads lead VBZ cord-335975-m6lkrehi 481 15 to to IN cord-335975-m6lkrehi 481 16 only only RB cord-335975-m6lkrehi 481 17 a a DT cord-335975-m6lkrehi 481 18 minority minority NN cord-335975-m6lkrehi 481 19 of of IN cord-335975-m6lkrehi 481 20 the the DT cord-335975-m6lkrehi 481 21 arterial arterial JJ cord-335975-m6lkrehi 481 22 partial partial JJ cord-335975-m6lkrehi 481 23 pressure pressure NN cord-335975-m6lkrehi 481 24 of of IN cord-335975-m6lkrehi 481 25 oxygen oxygen NN cord-335975-m6lkrehi 481 26 ( ( -LRB- cord-335975-m6lkrehi 481 27 PaO2 pao2 NN cord-335975-m6lkrehi 481 28 ) ) -RRB- cord-335975-m6lkrehi 481 29 that that WDT cord-335975-m6lkrehi 481 30 are be VBP cord-335975-m6lkrehi 481 31 usable usable JJ cord-335975-m6lkrehi 481 32 to to TO cord-335975-m6lkrehi 481 33 calculate calculate VB cord-335975-m6lkrehi 481 34 a a DT cord-335975-m6lkrehi 481 35 valid valid JJ cord-335975-m6lkrehi 481 36 oxygenation oxygenation NN cord-335975-m6lkrehi 481 37 index index NN cord-335975-m6lkrehi 481 38 ( ( -LRB- cord-335975-m6lkrehi 481 39 OI OI NNP cord-335975-m6lkrehi 481 40 ) ) -RRB- cord-335975-m6lkrehi 481 41 . . . cord-335975-m6lkrehi 482 1 If if IN cord-335975-m6lkrehi 482 2 not not RB cord-335975-m6lkrehi 482 3 available available JJ cord-335975-m6lkrehi 482 4 , , , cord-335975-m6lkrehi 482 5 PaO2 PaO2 NNS cord-335975-m6lkrehi 482 6 should should MD cord-335975-m6lkrehi 482 7 be be VB cord-335975-m6lkrehi 482 8 replaced replace VBN cord-335975-m6lkrehi 482 9 by by IN cord-335975-m6lkrehi 482 10 the the DT cord-335975-m6lkrehi 482 11 SpO2 SpO2 NNP cord-335975-m6lkrehi 482 12 if if IN cord-335975-m6lkrehi 482 13 < < NNP cord-335975-m6lkrehi 482 14 98 98 CD cord-335975-m6lkrehi 482 15 % % NN cord-335975-m6lkrehi 482 16 to to TO cord-335975-m6lkrehi 482 17 calculate calculate VB cord-335975-m6lkrehi 482 18 the the DT cord-335975-m6lkrehi 482 19 oxygen oxygen NN cord-335975-m6lkrehi 482 20 saturation saturation NN cord-335975-m6lkrehi 482 21 index index NN cord-335975-m6lkrehi 482 22 ( ( -LRB- cord-335975-m6lkrehi 482 23 OSI OSI NNP cord-335975-m6lkrehi 482 24 ) ) -RRB- cord-335975-m6lkrehi 482 25 . . . cord-335975-m6lkrehi 483 1 Using use VBG cord-335975-m6lkrehi 483 2 a a DT cord-335975-m6lkrehi 483 3 high high JJ cord-335975-m6lkrehi 483 4 temporal temporal JJ cord-335975-m6lkrehi 483 5 resolution resolution NN cord-335975-m6lkrehi 483 6 ( ( -LRB- cord-335975-m6lkrehi 483 7 HTR HTR NNP cord-335975-m6lkrehi 483 8 ) ) -RRB- cord-335975-m6lkrehi 483 9 database database NN cord-335975-m6lkrehi 483 10 that that WDT cord-335975-m6lkrehi 483 11 records record VBZ cord-335975-m6lkrehi 483 12 data datum NNS cord-335975-m6lkrehi 483 13 every every DT cord-335975-m6lkrehi 483 14 5 5 CD cord-335975-m6lkrehi 483 15 - - SYM cord-335975-m6lkrehi 483 16 30 30 CD cord-335975-m6lkrehi 483 17 s s NNPS cord-335975-m6lkrehi 483 18 , , , cord-335975-m6lkrehi 483 19 we -PRON- PRP cord-335975-m6lkrehi 483 20 aim aim VBP cord-335975-m6lkrehi 483 21 to to TO cord-335975-m6lkrehi 483 22 develop develop VB cord-335975-m6lkrehi 483 23 a a DT cord-335975-m6lkrehi 483 24 relevant relevant JJ cord-335975-m6lkrehi 483 25 clinical clinical JJ cord-335975-m6lkrehi 483 26 algorithm algorithm NN cord-335975-m6lkrehi 483 27 of of IN cord-335975-m6lkrehi 483 28 mass mass JJ cord-335975-m6lkrehi 483 29 data data NN cord-335975-m6lkrehi 483 30 aggregation aggregation NN cord-335975-m6lkrehi 483 31 to to TO cord-335975-m6lkrehi 483 32 improve improve VB cord-335975-m6lkrehi 483 33 PARDS PARDS NNP cord-335975-m6lkrehi 483 34 screening screening NN cord-335975-m6lkrehi 483 35 with with IN cord-335975-m6lkrehi 483 36 the the DT cord-335975-m6lkrehi 483 37 automatic automatic JJ cord-335975-m6lkrehi 483 38 OI OI NNP cord-335975-m6lkrehi 483 39 and and CC cord-335975-m6lkrehi 483 40 OSI OSI NNP cord-335975-m6lkrehi 483 41 calculation calculation NN cord-335975-m6lkrehi 483 42 . . . cord-335975-m6lkrehi 484 1 Patients patient NNS cord-335975-m6lkrehi 484 2 and and CC cord-335975-m6lkrehi 484 3 methods method NNS cord-335975-m6lkrehi 484 4 : : : cord-335975-m6lkrehi 484 5 All all PDT cord-335975-m6lkrehi 484 6 the the DT cord-335975-m6lkrehi 484 7 patients patient NNS cord-335975-m6lkrehi 484 8 admitted admit VBN cord-335975-m6lkrehi 484 9 to to IN cord-335975-m6lkrehi 484 10 our -PRON- PRP$ cord-335975-m6lkrehi 484 11 Pediatric Pediatric NNP cord-335975-m6lkrehi 484 12 ICU ICU NNP cord-335975-m6lkrehi 484 13 between between IN cord-335975-m6lkrehi 484 14 May May NNP cord-335975-m6lkrehi 484 15 2015 2015 CD cord-335975-m6lkrehi 484 16 and and CC cord-335975-m6lkrehi 484 17 August August NNP cord-335975-m6lkrehi 484 18 2017 2017 CD cord-335975-m6lkrehi 484 19 were be VBD cord-335975-m6lkrehi 484 20 included include VBN cord-335975-m6lkrehi 484 21 . . . cord-335975-m6lkrehi 485 1 The the DT cord-335975-m6lkrehi 485 2 HTR HTR NNP cord-335975-m6lkrehi 485 3 and and CC cord-335975-m6lkrehi 485 4 the the DT cord-335975-m6lkrehi 485 5 electronic electronic JJ cord-335975-m6lkrehi 485 6 medical medical JJ cord-335975-m6lkrehi 485 7 records record NNS cord-335975-m6lkrehi 485 8 ( ( -LRB- cord-335975-m6lkrehi 485 9 EMR EMR NNP cord-335975-m6lkrehi 485 10 ) ) -RRB- cord-335975-m6lkrehi 485 11 were be VBD cord-335975-m6lkrehi 485 12 queried query VBN cord-335975-m6lkrehi 485 13 through through IN cord-335975-m6lkrehi 485 14 Structured Structured NNP cord-335975-m6lkrehi 485 15 Query Query NNP cord-335975-m6lkrehi 485 16 Language Language NNP cord-335975-m6lkrehi 485 17 ( ( -LRB- cord-335975-m6lkrehi 485 18 SQL SQL NNP cord-335975-m6lkrehi 485 19 ) ) -RRB- cord-335975-m6lkrehi 485 20 following follow VBG cord-335975-m6lkrehi 485 21 these these DT cord-335975-m6lkrehi 485 22 steps-(1 steps-(1 CD cord-335975-m6lkrehi 485 23 ) ) -RRB- cord-335975-m6lkrehi 486 1 Data data NN cord-335975-m6lkrehi 486 2 selection selection NN cord-335975-m6lkrehi 486 3 ( ( -LRB- cord-335975-m6lkrehi 486 4 2 2 CD cord-335975-m6lkrehi 486 5 ) ) -RRB- cord-335975-m6lkrehi 486 6 Extraction extraction NN cord-335975-m6lkrehi 486 7 to to IN cord-335975-m6lkrehi 486 8 a a DT cord-335975-m6lkrehi 486 9 linear linear JJ cord-335975-m6lkrehi 486 10 format format NN cord-335975-m6lkrehi 486 11 ( ( -LRB- cord-335975-m6lkrehi 486 12 3 3 CD cord-335975-m6lkrehi 486 13 ) ) -RRB- cord-335975-m6lkrehi 486 14 Date date NN cord-335975-m6lkrehi 486 15 and and CC cord-335975-m6lkrehi 486 16 time time NN cord-335975-m6lkrehi 486 17 synchronization synchronization NN cord-335975-m6lkrehi 486 18 ( ( -LRB- cord-335975-m6lkrehi 486 19 4 4 CD cord-335975-m6lkrehi 486 20 ) ) -RRB- cord-335975-m6lkrehi 486 21 Data data NN cord-335975-m6lkrehi 486 22 pivoting pivoting NN cord-335975-m6lkrehi 486 23 ( ( -LRB- cord-335975-m6lkrehi 486 24 5 5 CD cord-335975-m6lkrehi 486 25 ) ) -RRB- cord-335975-m6lkrehi 486 26 Aggregation aggregation NN cord-335975-m6lkrehi 486 27 through through IN cord-335975-m6lkrehi 486 28 a a DT cord-335975-m6lkrehi 486 29 10-min 10-min CD cord-335975-m6lkrehi 486 30 moving move VBG cord-335975-m6lkrehi 486 31 average average NN cord-335975-m6lkrehi 486 32 ( ( -LRB- cord-335975-m6lkrehi 486 33 6 6 CD cord-335975-m6lkrehi 486 34 ) ) -RRB- cord-335975-m6lkrehi 486 35 Hypoxemia hypoxemia NN cord-335975-m6lkrehi 486 36 calculation calculation NN cord-335975-m6lkrehi 486 37 . . . cord-335975-m6lkrehi 487 1 Statistical statistical JJ cord-335975-m6lkrehi 487 2 analysis analysis NN cord-335975-m6lkrehi 487 3 included include VBD cord-335975-m6lkrehi 487 4 proportions proportion NNS cord-335975-m6lkrehi 487 5 , , , cord-335975-m6lkrehi 487 6 correlations correlation NNS cord-335975-m6lkrehi 487 7 and and CC cord-335975-m6lkrehi 487 8 Bland Bland NNP cord-335975-m6lkrehi 487 9 - - HYPH cord-335975-m6lkrehi 487 10 Altman Altman NNP cord-335975-m6lkrehi 487 11 analysis analysis NN cord-335975-m6lkrehi 487 12 . . . cord-335975-m6lkrehi 488 1 Results result NNS cord-335975-m6lkrehi 488 2 : : : cord-335975-m6lkrehi 489 1 Between between IN cord-335975-m6lkrehi 489 2 May May NNP cord-335975-m6lkrehi 489 3 2015 2015 CD cord-335975-m6lkrehi 489 4 and and CC cord-335975-m6lkrehi 489 5 August August NNP cord-335975-m6lkrehi 489 6 2017 2017 CD cord-335975-m6lkrehi 489 7 , , , cord-335975-m6lkrehi 489 8 1793 1793 CD cord-335975-m6lkrehi 489 9 patients patient NNS cord-335975-m6lkrehi 489 10 ( ( -LRB- cord-335975-m6lkrehi 489 11 2210 2210 CD cord-335975-m6lkrehi 489 12 stays stay VBZ cord-335975-m6lkrehi 489 13 ) ) -RRB- cord-335975-m6lkrehi 489 14 were be VBD cord-335975-m6lkrehi 489 15 admitted admit VBN cord-335975-m6lkrehi 489 16 to to IN cord-335975-m6lkrehi 489 17 the the DT cord-335975-m6lkrehi 489 18 PICU PICU NNP cord-335975-m6lkrehi 489 19 . . . cord-335975-m6lkrehi 490 1 Approximately approximately RB cord-335975-m6lkrehi 490 2 46 46 CD cord-335975-m6lkrehi 490 3 million million CD cord-335975-m6lkrehi 490 4 rows row NNS cord-335975-m6lkrehi 490 5 were be VBD cord-335975-m6lkrehi 490 6 retrieved retrieve VBN cord-335975-m6lkrehi 490 7 from from IN cord-335975-m6lkrehi 490 8 the the DT cord-335975-m6lkrehi 490 9 databases database NNS cord-335975-m6lkrehi 490 10 including include VBG cord-335975-m6lkrehi 490 11 19,189 19,189 CD cord-335975-m6lkrehi 490 12 PaO2 pao2 JJ cord-335975-m6lkrehi 490 13 values value NNS cord-335975-m6lkrehi 490 14 . . . cord-335975-m6lkrehi 491 1 The the DT cord-335975-m6lkrehi 491 2 algorithm algorithm NN cord-335975-m6lkrehi 491 3 was be VBD cord-335975-m6lkrehi 491 4 able able JJ cord-335975-m6lkrehi 491 5 to to TO cord-335975-m6lkrehi 491 6 calculate calculate VB cord-335975-m6lkrehi 491 7 11,320 11,320 CD cord-335975-m6lkrehi 491 8 ( ( -LRB- cord-335975-m6lkrehi 491 9 59 59 CD cord-335975-m6lkrehi 491 10 % % NN cord-335975-m6lkrehi 491 11 of of IN cord-335975-m6lkrehi 491 12 the the DT cord-335975-m6lkrehi 491 13 PaO2 PaO2 NNS cord-335975-m6lkrehi 491 14 ) ) -RRB- cord-335975-m6lkrehi 492 1 OI OI NNP cord-335975-m6lkrehi 492 2 and and CC cord-335975-m6lkrehi 492 3 5204 5204 CD cord-335975-m6lkrehi 492 4 OSI OSI NNP cord-335975-m6lkrehi 492 5 . . . cord-335975-m6lkrehi 493 1 The the DT cord-335975-m6lkrehi 493 2 comparison comparison NN cord-335975-m6lkrehi 493 3 between between IN cord-335975-m6lkrehi 493 4 OI OI NNP cord-335975-m6lkrehi 493 5 and and CC cord-335975-m6lkrehi 493 6 OSI OSI NNP cord-335975-m6lkrehi 493 7 showed show VBD cord-335975-m6lkrehi 493 8 that that IN cord-335975-m6lkrehi 493 9 97.4 97.4 CD cord-335975-m6lkrehi 493 10 % % NN cord-335975-m6lkrehi 493 11 of of IN cord-335975-m6lkrehi 493 12 the the DT cord-335975-m6lkrehi 493 13 results result NNS cord-335975-m6lkrehi 493 14 were be VBD cord-335975-m6lkrehi 493 15 between between IN cord-335975-m6lkrehi 493 16 the the DT cord-335975-m6lkrehi 493 17 limits limit NNS cord-335975-m6lkrehi 493 18 of of IN cord-335975-m6lkrehi 493 19 agreements agreement NNS cord-335975-m6lkrehi 493 20 ( ( -LRB- cord-335975-m6lkrehi 493 21 − − CD cord-335975-m6lkrehi 493 22 17.2 17.2 CD cord-335975-m6lkrehi 493 23 + + SYM cord-335975-m6lkrehi 493 24 10.6 10.6 CD cord-335975-m6lkrehi 493 25 ) ) -RRB- cord-335975-m6lkrehi 493 26 , , , cord-335975-m6lkrehi 493 27 a a DT cord-335975-m6lkrehi 493 28 bias bias NN cord-335975-m6lkrehi 493 29 of of IN cord-335975-m6lkrehi 493 30 − − NNP cord-335975-m6lkrehi 493 31 3.3 3.3 CD cord-335975-m6lkrehi 493 32 and and CC cord-335975-m6lkrehi 493 33 a a DT cord-335975-m6lkrehi 493 34 correlation correlation NN cord-335975-m6lkrehi 493 35 R2 r2 NN cord-335975-m6lkrehi 493 36 = = SYM cord-335975-m6lkrehi 493 37 0.643 0.643 CD cord-335975-m6lkrehi 493 38 . . . cord-335975-m6lkrehi 494 1 The the DT cord-335975-m6lkrehi 494 2 comparison comparison NN cord-335975-m6lkrehi 494 3 between between IN cord-335975-m6lkrehi 494 4 the the DT cord-335975-m6lkrehi 494 5 OIs OIs NNP cord-335975-m6lkrehi 494 6 from from IN cord-335975-m6lkrehi 494 7 the the DT cord-335975-m6lkrehi 494 8 HTR HTR NNP cord-335975-m6lkrehi 494 9 and and CC cord-335975-m6lkrehi 494 10 EMR EMR NNP cord-335975-m6lkrehi 494 11 databases database NNS cord-335975-m6lkrehi 494 12 showed show VBD cord-335975-m6lkrehi 494 13 that that IN cord-335975-m6lkrehi 494 14 94.6 94.6 CD cord-335975-m6lkrehi 494 15 % % NN cord-335975-m6lkrehi 494 16 of of IN cord-335975-m6lkrehi 494 17 the the DT cord-335975-m6lkrehi 494 18 results result NNS cord-335975-m6lkrehi 494 19 were be VBD cord-335975-m6lkrehi 494 20 between between IN cord-335975-m6lkrehi 494 21 the the DT cord-335975-m6lkrehi 494 22 limits limit NNS cord-335975-m6lkrehi 494 23 of of IN cord-335975-m6lkrehi 494 24 agreements agreement NNS cord-335975-m6lkrehi 494 25 ( ( -LRB- cord-335975-m6lkrehi 494 26 − − CD cord-335975-m6lkrehi 494 27 5.47 5.47 CD cord-335975-m6lkrehi 494 28 + + SYM cord-335975-m6lkrehi 494 29 5.39 5.39 CD cord-335975-m6lkrehi 494 30 ) ) -RRB- cord-335975-m6lkrehi 494 31 , , , cord-335975-m6lkrehi 494 32 a a DT cord-335975-m6lkrehi 494 33 bias bias NN cord-335975-m6lkrehi 494 34 of of IN cord-335975-m6lkrehi 494 35 − − CD cord-335975-m6lkrehi 494 36 0.04 0.04 CD cord-335975-m6lkrehi 494 37 and and CC cord-335975-m6lkrehi 494 38 R2 r2 NN cord-335975-m6lkrehi 494 39 = = SYM cord-335975-m6lkrehi 494 40 0.904 0.904 CD cord-335975-m6lkrehi 494 41 . . . cord-335975-m6lkrehi 495 1 Conclusion conclusion NN cord-335975-m6lkrehi 495 2 : : : cord-335975-m6lkrehi 495 3 Using use VBG cord-335975-m6lkrehi 495 4 a a DT cord-335975-m6lkrehi 495 5 mass mass JJ cord-335975-m6lkrehi 495 6 data data NN cord-335975-m6lkrehi 495 7 aggregation aggregation NN cord-335975-m6lkrehi 495 8 algorithm algorithm NN cord-335975-m6lkrehi 495 9 on on IN cord-335975-m6lkrehi 495 10 a a DT cord-335975-m6lkrehi 495 11 HTR HTR NNP cord-335975-m6lkrehi 495 12 database database NN cord-335975-m6lkrehi 495 13 allows allow VBZ cord-335975-m6lkrehi 495 14 more more JJR cord-335975-m6lkrehi 495 15 PaO2 PaO2 NNS cord-335975-m6lkrehi 495 16 to to TO cord-335975-m6lkrehi 495 17 be be VB cord-335975-m6lkrehi 495 18 used use VBN cord-335975-m6lkrehi 495 19 to to TO cord-335975-m6lkrehi 495 20 calculate calculate VB cord-335975-m6lkrehi 495 21 an an DT cord-335975-m6lkrehi 495 22 OI OI NNP cord-335975-m6lkrehi 495 23 than than IN cord-335975-m6lkrehi 495 24 the the DT cord-335975-m6lkrehi 495 25 usual usual JJ cord-335975-m6lkrehi 495 26 EMR EMR NNP cord-335975-m6lkrehi 495 27 . . . cord-335975-m6lkrehi 496 1 The the DT cord-335975-m6lkrehi 496 2 OI OI NNP cord-335975-m6lkrehi 496 3 results result NNS cord-335975-m6lkrehi 496 4 differ differ VBP cord-335975-m6lkrehi 496 5 slightly slightly RB cord-335975-m6lkrehi 496 6 between between IN cord-335975-m6lkrehi 496 7 the the DT cord-335975-m6lkrehi 496 8 HTR HTR NNP cord-335975-m6lkrehi 496 9 and and CC cord-335975-m6lkrehi 496 10 the the DT cord-335975-m6lkrehi 496 11 EMR EMR NNP cord-335975-m6lkrehi 496 12 . . . cord-335975-m6lkrehi 497 1 The the DT cord-335975-m6lkrehi 497 2 accuracy accuracy NN cord-335975-m6lkrehi 497 3 is be VBZ cord-335975-m6lkrehi 497 4 probably probably RB cord-335975-m6lkrehi 497 5 in in IN cord-335975-m6lkrehi 497 6 favor favor NN cord-335975-m6lkrehi 497 7 of of IN cord-335975-m6lkrehi 497 8 the the DT cord-335975-m6lkrehi 497 9 HTR HTR NNP cord-335975-m6lkrehi 497 10 because because IN cord-335975-m6lkrehi 497 11 of of IN cord-335975-m6lkrehi 497 12 the the DT cord-335975-m6lkrehi 497 13 shorter short JJR cord-335975-m6lkrehi 497 14 timelapse timelapse NN cord-335975-m6lkrehi 497 15 between between IN cord-335975-m6lkrehi 497 16 the the DT cord-335975-m6lkrehi 497 17 OI OI NNP cord-335975-m6lkrehi 497 18 parameters parameter NNS cord-335975-m6lkrehi 497 19 . . . cord-335975-m6lkrehi 498 1 The the DT cord-335975-m6lkrehi 498 2 OSI OSI NNP cord-335975-m6lkrehi 498 3 is be VBZ cord-335975-m6lkrehi 498 4 possibly possibly RB cord-335975-m6lkrehi 498 5 a a DT cord-335975-m6lkrehi 498 6 biased biased JJ cord-335975-m6lkrehi 498 7 OI oi NN cord-335975-m6lkrehi 498 8 surrogate surrogate NN cord-335975-m6lkrehi 498 9 and and CC cord-335975-m6lkrehi 498 10 should should MD cord-335975-m6lkrehi 498 11 be be VB cord-335975-m6lkrehi 498 12 interpreted interpret VBN cord-335975-m6lkrehi 498 13 with with IN cord-335975-m6lkrehi 498 14 caution caution NN cord-335975-m6lkrehi 498 15 . . . cord-335975-m6lkrehi 499 1 Our -PRON- PRP$ cord-335975-m6lkrehi 499 2 next next JJ cord-335975-m6lkrehi 499 3 step step NN cord-335975-m6lkrehi 499 4 will will MD cord-335975-m6lkrehi 499 5 be be VB cord-335975-m6lkrehi 499 6 to to TO cord-335975-m6lkrehi 499 7 measure measure VB cord-335975-m6lkrehi 499 8 the the DT cord-335975-m6lkrehi 499 9 impact impact NN cord-335975-m6lkrehi 499 10 of of IN cord-335975-m6lkrehi 499 11 the the DT cord-335975-m6lkrehi 499 12 algorithm algorithm NN cord-335975-m6lkrehi 499 13 on on IN cord-335975-m6lkrehi 499 14 the the DT cord-335975-m6lkrehi 499 15 PARDS PARDS NNP cord-335975-m6lkrehi 499 16 real real JJ cord-335975-m6lkrehi 499 17 - - HYPH cord-335975-m6lkrehi 499 18 time time NN cord-335975-m6lkrehi 499 19 diagnosis diagnosis NN cord-335975-m6lkrehi 499 20 and and CC cord-335975-m6lkrehi 499 21 PARDS PARDS NNP cord-335975-m6lkrehi 499 22 severity severity NN cord-335975-m6lkrehi 499 23 categories category NNS cord-335975-m6lkrehi 499 24 . . . cord-335975-m6lkrehi 500 1 Introduction introduction NN cord-335975-m6lkrehi 500 2 : : : cord-335975-m6lkrehi 501 1 Early early JJ cord-335975-m6lkrehi 501 2 administration administration NN cord-335975-m6lkrehi 501 3 of of IN cord-335975-m6lkrehi 501 4 appropriate appropriate JJ cord-335975-m6lkrehi 501 5 antibiotic antibiotic JJ cord-335975-m6lkrehi 501 6 therapy therapy NN cord-335975-m6lkrehi 501 7 with with IN cord-335975-m6lkrehi 501 8 adequate adequate JJ cord-335975-m6lkrehi 501 9 concentration concentration NN cord-335975-m6lkrehi 501 10 is be VBZ cord-335975-m6lkrehi 501 11 the the DT cord-335975-m6lkrehi 501 12 cornerstone cornerstone NN cord-335975-m6lkrehi 501 13 of of IN cord-335975-m6lkrehi 501 14 the the DT cord-335975-m6lkrehi 501 15 severe severe JJ cord-335975-m6lkrehi 501 16 sepsis sepsis NN cord-335975-m6lkrehi 501 17 and and CC cord-335975-m6lkrehi 501 18 septic septic JJ cord-335975-m6lkrehi 501 19 shock shock NN cord-335975-m6lkrehi 501 20 's 's POS cord-335975-m6lkrehi 501 21 treatment treatment NN cord-335975-m6lkrehi 501 22 . . . cord-335975-m6lkrehi 502 1 Adult adult NN cord-335975-m6lkrehi 502 2 studies study NNS cord-335975-m6lkrehi 502 3 showed show VBD cord-335975-m6lkrehi 502 4 alteration alteration NN cord-335975-m6lkrehi 502 5 of of IN cord-335975-m6lkrehi 502 6 distribution distribution NN cord-335975-m6lkrehi 502 7 and and CC cord-335975-m6lkrehi 502 8 elimination elimination NN cord-335975-m6lkrehi 502 9 which which WDT cord-335975-m6lkrehi 502 10 can can MD cord-335975-m6lkrehi 502 11 lead lead VB cord-335975-m6lkrehi 502 12 to to IN cord-335975-m6lkrehi 502 13 insufficient insufficient JJ cord-335975-m6lkrehi 502 14 drug drug NN cord-335975-m6lkrehi 502 15 concentration concentration NN cord-335975-m6lkrehi 502 16 in in IN cord-335975-m6lkrehi 502 17 septic septic JJ cord-335975-m6lkrehi 502 18 patients patient NNS cord-335975-m6lkrehi 502 19 . . . cord-335975-m6lkrehi 503 1 In in IN cord-335975-m6lkrehi 503 2 children child NNS cord-335975-m6lkrehi 503 3 , , , cord-335975-m6lkrehi 503 4 studies study NNS cord-335975-m6lkrehi 503 5 are be VBP cord-335975-m6lkrehi 503 6 lacking lack VBG cord-335975-m6lkrehi 503 7 and and CC cord-335975-m6lkrehi 503 8 antibiotic antibiotic JJ cord-335975-m6lkrehi 503 9 dosing dosing NN cord-335975-m6lkrehi 503 10 may may MD cord-335975-m6lkrehi 503 11 be be VB cord-335975-m6lkrehi 503 12 suboptimal suboptimal JJ cord-335975-m6lkrehi 503 13 . . . cord-335975-m6lkrehi 504 1 We -PRON- PRP cord-335975-m6lkrehi 504 2 aim aim VBP cord-335975-m6lkrehi 504 3 to to TO cord-335975-m6lkrehi 504 4 describe describe VB cord-335975-m6lkrehi 504 5 the the DT cord-335975-m6lkrehi 504 6 plasma plasma NN cord-335975-m6lkrehi 504 7 concentration concentration NN cord-335975-m6lkrehi 504 8 of of IN cord-335975-m6lkrehi 504 9 the the DT cord-335975-m6lkrehi 504 10 most most RBS cord-335975-m6lkrehi 504 11 used use VBN cord-335975-m6lkrehi 504 12 beta beta NN cord-335975-m6lkrehi 504 13 - - HYPH cord-335975-m6lkrehi 504 14 lactam lactam NNS cord-335975-m6lkrehi 504 15 in in IN cord-335975-m6lkrehi 504 16 critically critically RB cord-335975-m6lkrehi 504 17 ill ill JJ cord-335975-m6lkrehi 504 18 children child NNS cord-335975-m6lkrehi 504 19 , , , cord-335975-m6lkrehi 504 20 to to TO cord-335975-m6lkrehi 504 21 describe describe VB cord-335975-m6lkrehi 504 22 the the DT cord-335975-m6lkrehi 504 23 rate rate NN cord-335975-m6lkrehi 504 24 of of IN cord-335975-m6lkrehi 504 25 patients patient NNS cord-335975-m6lkrehi 504 26 with with IN cord-335975-m6lkrehi 504 27 suboptimal suboptimal JJ cord-335975-m6lkrehi 504 28 exposure exposure NN cord-335975-m6lkrehi 504 29 and and CC cord-335975-m6lkrehi 504 30 associating associate VBG cord-335975-m6lkrehi 504 31 clinical clinical JJ cord-335975-m6lkrehi 504 32 and and CC cord-335975-m6lkrehi 504 33 biological biological JJ cord-335975-m6lkrehi 504 34 factors factor NNS cord-335975-m6lkrehi 504 35 . . . cord-335975-m6lkrehi 505 1 Patients patient NNS cord-335975-m6lkrehi 505 2 and and CC cord-335975-m6lkrehi 505 3 methods method NNS cord-335975-m6lkrehi 506 1 : : : cord-335975-m6lkrehi 506 2 This this DT cord-335975-m6lkrehi 506 3 was be VBD cord-335975-m6lkrehi 506 4 a a DT cord-335975-m6lkrehi 506 5 prospective prospective JJ cord-335975-m6lkrehi 506 6 , , , cord-335975-m6lkrehi 506 7 single single JJ cord-335975-m6lkrehi 506 8 center center NN cord-335975-m6lkrehi 506 9 , , , cord-335975-m6lkrehi 506 10 observational observational JJ cord-335975-m6lkrehi 506 11 study study NN cord-335975-m6lkrehi 506 12 designed design VBN cord-335975-m6lkrehi 506 13 in in IN cord-335975-m6lkrehi 506 14 32 32 CD cord-335975-m6lkrehi 506 15 beds bed NNS cord-335975-m6lkrehi 506 16 Pediatric Pediatric NNP cord-335975-m6lkrehi 506 17 Intensive Intensive NNP cord-335975-m6lkrehi 506 18 Care Care NNP cord-335975-m6lkrehi 506 19 Unit Unit NNP cord-335975-m6lkrehi 506 20 ( ( -LRB- cord-335975-m6lkrehi 506 21 PICU PICU NNP cord-335975-m6lkrehi 506 22 ) ) -RRB- cord-335975-m6lkrehi 506 23 and and CC cord-335975-m6lkrehi 506 24 high high JJ cord-335975-m6lkrehi 506 25 dependency dependency NN cord-335975-m6lkrehi 506 26 care care NN cord-335975-m6lkrehi 506 27 at at IN cord-335975-m6lkrehi 506 28 the the DT cord-335975-m6lkrehi 506 29 Necker Necker NNP cord-335975-m6lkrehi 506 30 Hospital Hospital NNP cord-335975-m6lkrehi 506 31 ( ( -LRB- cord-335975-m6lkrehi 506 32 Paris Paris NNP cord-335975-m6lkrehi 506 33 , , , cord-335975-m6lkrehi 506 34 France France NNP cord-335975-m6lkrehi 506 35 ) ) -RRB- cord-335975-m6lkrehi 506 36 from from IN cord-335975-m6lkrehi 506 37 January January NNP cord-335975-m6lkrehi 506 38 2016 2016 CD cord-335975-m6lkrehi 506 39 to to IN cord-335975-m6lkrehi 506 40 May May NNP cord-335975-m6lkrehi 506 41 2017 2017 CD cord-335975-m6lkrehi 506 42 . . . cord-335975-m6lkrehi 507 1 Were be VBD cord-335975-m6lkrehi 507 2 included include VBN cord-335975-m6lkrehi 507 3 , , , cord-335975-m6lkrehi 507 4 children child NNS cord-335975-m6lkrehi 507 5 with with IN cord-335975-m6lkrehi 507 6 severe severe JJ cord-335975-m6lkrehi 507 7 sepsis sepsis NN cord-335975-m6lkrehi 507 8 or or CC cord-335975-m6lkrehi 507 9 septic septic JJ cord-335975-m6lkrehi 507 10 shock shock NN cord-335975-m6lkrehi 507 11 , , , cord-335975-m6lkrehi 507 12 aged aged JJ cord-335975-m6lkrehi 507 13 less less JJR cord-335975-m6lkrehi 507 14 than than IN cord-335975-m6lkrehi 507 15 18 18 CD cord-335975-m6lkrehi 507 16 years year NNS cord-335975-m6lkrehi 507 17 and and CC cord-335975-m6lkrehi 507 18 weighing weigh VBG cord-335975-m6lkrehi 507 19 more more JJR cord-335975-m6lkrehi 507 20 than than IN cord-335975-m6lkrehi 507 21 2.5 2.5 CD cord-335975-m6lkrehi 507 22 kg kg NNS cord-335975-m6lkrehi 507 23 , , , cord-335975-m6lkrehi 507 24 and and CC cord-335975-m6lkrehi 507 25 receiving receive VBG cord-335975-m6lkrehi 507 26 one one CD cord-335975-m6lkrehi 507 27 or or CC cord-335975-m6lkrehi 507 28 more more JJR cord-335975-m6lkrehi 507 29 of of IN cord-335975-m6lkrehi 507 30 the the DT cord-335975-m6lkrehi 507 31 following follow VBG cord-335975-m6lkrehi 507 32 antibiotics antibiotic NNS cord-335975-m6lkrehi 507 33 - - HYPH cord-335975-m6lkrehi 507 34 amoxicillin amoxicillin NNP cord-335975-m6lkrehi 507 35 , , , cord-335975-m6lkrehi 507 36 cefotaxime cefotaxime NNP cord-335975-m6lkrehi 507 37 , , , cord-335975-m6lkrehi 507 38 cefazolin cefazolin NNP cord-335975-m6lkrehi 507 39 , , , cord-335975-m6lkrehi 507 40 ceftazidime ceftazidime NN cord-335975-m6lkrehi 507 41 , , , cord-335975-m6lkrehi 507 42 piperacillin piperacillin NNP cord-335975-m6lkrehi 507 43 - - HYPH cord-335975-m6lkrehi 507 44 tazobactam tazobactam NNP cord-335975-m6lkrehi 507 45 , , , cord-335975-m6lkrehi 507 46 meropenem meropenem NNP cord-335975-m6lkrehi 507 47 and and CC cord-335975-m6lkrehi 507 48 imipenem imipenem NNP cord-335975-m6lkrehi 507 49 for for IN cord-335975-m6lkrehi 507 50 suspected suspect VBN cord-335975-m6lkrehi 507 51 or or CC cord-335975-m6lkrehi 507 52 proven prove VBN cord-335975-m6lkrehi 507 53 infection infection NN cord-335975-m6lkrehi 507 54 . . . cord-335975-m6lkrehi 508 1 Betalactam Betalactam NNP cord-335975-m6lkrehi 508 2 plasma plasma NN cord-335975-m6lkrehi 508 3 concentrations concentration NNS cord-335975-m6lkrehi 508 4 were be VBD cord-335975-m6lkrehi 508 5 analysed analyse VBN cord-335975-m6lkrehi 508 6 using use VBG cord-335975-m6lkrehi 508 7 High High NNP cord-335975-m6lkrehi 508 8 Performance Performance NNP cord-335975-m6lkrehi 508 9 Liquid Liquid NNP cord-335975-m6lkrehi 508 10 Chromatography Chromatography NNP cord-335975-m6lkrehi 508 11 . . . cord-335975-m6lkrehi 509 1 Results result NNS cord-335975-m6lkrehi 509 2 : : : cord-335975-m6lkrehi 510 1 We -PRON- PRP cord-335975-m6lkrehi 510 2 enrolled enrol VBD cord-335975-m6lkrehi 510 3 37 37 CD cord-335975-m6lkrehi 510 4 children child NNS cord-335975-m6lkrehi 510 5 ( ( -LRB- cord-335975-m6lkrehi 510 6 severe severe JJ cord-335975-m6lkrehi 510 7 sepsis sepsis NN cord-335975-m6lkrehi 510 8 , , , cord-335975-m6lkrehi 510 9 n n NN cord-335975-m6lkrehi 510 10 = = SYM cord-335975-m6lkrehi 510 11 22 22 CD cord-335975-m6lkrehi 510 12 ( ( -LRB- cord-335975-m6lkrehi 510 13 59.5 59.5 CD cord-335975-m6lkrehi 510 14 % % NN cord-335975-m6lkrehi 510 15 ) ) -RRB- cord-335975-m6lkrehi 510 16 + + SYM cord-335975-m6lkrehi 510 17 septic septic JJ cord-335975-m6lkrehi 510 18 shock shock NN cord-335975-m6lkrehi 510 19 , , , cord-335975-m6lkrehi 510 20 n n NN cord-335975-m6lkrehi 510 21 = = SYM cord-335975-m6lkrehi 510 22 15 15 CD cord-335975-m6lkrehi 510 23 ( ( -LRB- cord-335975-m6lkrehi 510 24 40.5 40.5 CD cord-335975-m6lkrehi 510 25 % % NN cord-335975-m6lkrehi 510 26 ) ) -RRB- cord-335975-m6lkrehi 510 27 ) ) -RRB- cord-335975-m6lkrehi 510 28 with with IN cord-335975-m6lkrehi 510 29 a a DT cord-335975-m6lkrehi 510 30 median median JJ cord-335975-m6lkrehi 510 31 age age NN cord-335975-m6lkrehi 510 32 of of IN cord-335975-m6lkrehi 510 33 19 19 CD cord-335975-m6lkrehi 510 34 months month NNS cord-335975-m6lkrehi 510 35 ( ( -LRB- cord-335975-m6lkrehi 510 36 4 4 CD cord-335975-m6lkrehi 510 37 - - SYM cord-335975-m6lkrehi 510 38 64 64 CD cord-335975-m6lkrehi 510 39 . . . cord-335975-m6lkrehi 511 1 Bacteria Bacteria NNS cord-335975-m6lkrehi 511 2 were be VBD cord-335975-m6lkrehi 511 3 identified identify VBN cord-335975-m6lkrehi 511 4 in in IN cord-335975-m6lkrehi 511 5 26 26 CD cord-335975-m6lkrehi 511 6 patients patient NNS cord-335975-m6lkrehi 511 7 ( ( -LRB- cord-335975-m6lkrehi 511 8 70.3 70.3 CD cord-335975-m6lkrehi 511 9 % % NN cord-335975-m6lkrehi 511 10 ) ) -RRB- cord-335975-m6lkrehi 511 11 . . . cord-335975-m6lkrehi 512 1 A a DT cord-335975-m6lkrehi 512 2 total total NN cord-335975-m6lkrehi 512 3 of of IN cord-335975-m6lkrehi 512 4 132 132 CD cord-335975-m6lkrehi 512 5 blood blood NN cord-335975-m6lkrehi 512 6 samples sample NNS cord-335975-m6lkrehi 512 7 were be VBD cord-335975-m6lkrehi 512 8 analysed analyse VBN cord-335975-m6lkrehi 512 9 at at IN cord-335975-m6lkrehi 512 10 a a DT cord-335975-m6lkrehi 512 11 median median NN cord-335975-m6lkrehi 512 12 of of IN cord-335975-m6lkrehi 512 13 2 2 CD cord-335975-m6lkrehi 512 14 days day NNS cord-335975-m6lkrehi 512 15 ( ( -LRB- cord-335975-m6lkrehi 512 16 1 1 CD cord-335975-m6lkrehi 512 17 ) ) -RRB- cord-335975-m6lkrehi 512 18 ( ( -LRB- cord-335975-m6lkrehi 512 19 2 2 LS cord-335975-m6lkrehi 512 20 ) ) -RRB- cord-335975-m6lkrehi 512 21 ( ( -LRB- cord-335975-m6lkrehi 512 22 3 3 LS cord-335975-m6lkrehi 512 23 ) ) -RRB- cord-335975-m6lkrehi 512 24 ( ( -LRB- cord-335975-m6lkrehi 512 25 4 4 LS cord-335975-m6lkrehi 512 26 ) ) -RRB- cord-335975-m6lkrehi 512 27 ( ( -LRB- cord-335975-m6lkrehi 512 28 5 5 LS cord-335975-m6lkrehi 512 29 ) ) -RRB- cord-335975-m6lkrehi 512 30 ( ( -LRB- cord-335975-m6lkrehi 512 31 6 6 LS cord-335975-m6lkrehi 512 32 ) ) -RRB- cord-335975-m6lkrehi 512 33 ( ( -LRB- cord-335975-m6lkrehi 512 34 7 7 LS cord-335975-m6lkrehi 512 35 ) ) -RRB- cord-335975-m6lkrehi 512 36 ( ( -LRB- cord-335975-m6lkrehi 512 37 8) 8) NNP cord-335975-m6lkrehi 512 38 ( ( -LRB- cord-335975-m6lkrehi 512 39 9 9 CD cord-335975-m6lkrehi 512 40 ) ) -RRB- cord-335975-m6lkrehi 512 41 ( ( -LRB- cord-335975-m6lkrehi 512 42 10 10 CD cord-335975-m6lkrehi 512 43 ) ) -RRB- cord-335975-m6lkrehi 512 44 ( ( -LRB- cord-335975-m6lkrehi 512 45 11 11 CD cord-335975-m6lkrehi 512 46 ) ) -RRB- cord-335975-m6lkrehi 512 47 ( ( -LRB- cord-335975-m6lkrehi 512 48 12 12 CD cord-335975-m6lkrehi 512 49 ) ) -RRB- cord-335975-m6lkrehi 512 50 following follow VBG cord-335975-m6lkrehi 512 51 the the DT cord-335975-m6lkrehi 512 52 onset onset NN cord-335975-m6lkrehi 512 53 of of IN cord-335975-m6lkrehi 512 54 sepsis sepsis NN cord-335975-m6lkrehi 512 55 . . . cord-335975-m6lkrehi 513 1 Twenty twenty CD cord-335975-m6lkrehi 513 2 - - HYPH cord-335975-m6lkrehi 513 3 four four CD cord-335975-m6lkrehi 513 4 patients patient NNS cord-335975-m6lkrehi 513 5 ( ( -LRB- cord-335975-m6lkrehi 513 6 64.8 64.8 CD cord-335975-m6lkrehi 513 7 % % NN cord-335975-m6lkrehi 513 8 ) ) -RRB- cord-335975-m6lkrehi 513 9 had have VBD cord-335975-m6lkrehi 513 10 insufficient insufficient JJ cord-335975-m6lkrehi 513 11 concentration concentration NN cord-335975-m6lkrehi 513 12 ( ( -LRB- cord-335975-m6lkrehi 513 13 cefotaxime cefotaxime NNP cord-335975-m6lkrehi 513 14 7 7 CD cord-335975-m6lkrehi 513 15 14 14 CD cord-335975-m6lkrehi 513 16 ( ( -LRB- cord-335975-m6lkrehi 513 17 43 43 CD cord-335975-m6lkrehi 513 18 % % NN cord-335975-m6lkrehi 513 19 ) ) -RRB- cord-335975-m6lkrehi 514 1 + + CC cord-335975-m6lkrehi 514 2 piperacillin piperacillin NNP cord-335975-m6lkrehi 514 3 - - HYPH cord-335975-m6lkrehi 514 4 tazobactam tazobactam NNS cord-335975-m6lkrehi 514 5 , , , cord-335975-m6lkrehi 514 6 10 10 CD cord-335975-m6lkrehi 514 7 13 13 CD cord-335975-m6lkrehi 514 8 ( ( -LRB- cord-335975-m6lkrehi 514 9 77 77 CD cord-335975-m6lkrehi 514 10 % % NN cord-335975-m6lkrehi 514 11 ) ) -RRB- cord-335975-m6lkrehi 514 12 + + CC cord-335975-m6lkrehi 515 1 amoxicillin amoxicillin NNP cord-335975-m6lkrehi 515 2 6 6 CD cord-335975-m6lkrehi 515 3 7 7 CD cord-335975-m6lkrehi 515 4 ( ( -LRB- cord-335975-m6lkrehi 515 5 86 86 CD cord-335975-m6lkrehi 515 6 % % NN cord-335975-m6lkrehi 515 7 ) ) -RRB- cord-335975-m6lkrehi 516 1 + + CC cord-335975-m6lkrehi 516 2 meropenem meropenem NNP cord-335975-m6lkrehi 516 3 3 3 CD cord-335975-m6lkrehi 516 4 6 6 CD cord-335975-m6lkrehi 516 5 ( ( -LRB- cord-335975-m6lkrehi 516 6 50 50 CD cord-335975-m6lkrehi 516 7 % % NN cord-335975-m6lkrehi 516 8 ) ) -RRB- cord-335975-m6lkrehi 516 9 , , , cord-335975-m6lkrehi 516 10 cefazoline cefazoline NN cord-335975-m6lkrehi 516 11 1 1 CD cord-335975-m6lkrehi 516 12 4 4 CD cord-335975-m6lkrehi 516 13 ( ( -LRB- cord-335975-m6lkrehi 516 14 25 25 CD cord-335975-m6lkrehi 516 15 % % NN cord-335975-m6lkrehi 516 16 ) ) -RRB- cord-335975-m6lkrehi 516 17 , , , cord-335975-m6lkrehi 516 18 imipenem imipenem NNP cord-335975-m6lkrehi 516 19 0 0 CD cord-335975-m6lkrehi 516 20 2 2 CD cord-335975-m6lkrehi 516 21 ( ( -LRB- cord-335975-m6lkrehi 516 22 0 0 CD cord-335975-m6lkrehi 516 23 % % NN cord-335975-m6lkrehi 516 24 ) ) -RRB- cord-335975-m6lkrehi 517 1 + + CC cord-335975-m6lkrehi 517 2 ceftazidime ceftazidime NN cord-335975-m6lkrehi 517 3 0 0 CD cord-335975-m6lkrehi 517 4 1 1 CD cord-335975-m6lkrehi 517 5 ( ( -LRB- cord-335975-m6lkrehi 517 6 0 0 CD cord-335975-m6lkrehi 517 7 % % NN cord-335975-m6lkrehi 517 8 ) ) -RRB- cord-335975-m6lkrehi 517 9 ) ) -RRB- cord-335975-m6lkrehi 517 10 . . . cord-335975-m6lkrehi 518 1 Insufficient insufficient JJ cord-335975-m6lkrehi 518 2 concentrations concentration NNS cord-335975-m6lkrehi 518 3 were be VBD cord-335975-m6lkrehi 518 4 associated associate VBN cord-335975-m6lkrehi 518 5 with with IN cord-335975-m6lkrehi 518 6 early early JJ cord-335975-m6lkrehi 518 7 measurements measurement NNS cord-335975-m6lkrehi 518 8 ( ( -LRB- cord-335975-m6lkrehi 518 9 < < XX cord-335975-m6lkrehi 518 10 72 72 CD cord-335975-m6lkrehi 518 11 h h NN cord-335975-m6lkrehi 518 12 from from IN cord-335975-m6lkrehi 518 13 the the DT cord-335975-m6lkrehi 518 14 sepsis sepsis NN cord-335975-m6lkrehi 518 15 ' ' POS cord-335975-m6lkrehi 518 16 onset onset NN cord-335975-m6lkrehi 518 17 ) ) -RRB- cord-335975-m6lkrehi 518 18 ( ( -LRB- cord-335975-m6lkrehi 518 19 p p NN cord-335975-m6lkrehi 518 20 = = SYM cord-335975-m6lkrehi 518 21 0.035 0.035 CD cord-335975-m6lkrehi 518 22 ) ) -RRB- cord-335975-m6lkrehi 518 23 and and CC cord-335975-m6lkrehi 518 24 creatinine creatinine NN cord-335975-m6lkrehi 518 25 clearance clearance NN cord-335975-m6lkrehi 518 26 increase increase NN cord-335975-m6lkrehi 518 27 ( ( -LRB- cord-335975-m6lkrehi 518 28 p p NN cord-335975-m6lkrehi 518 29 = = SYM cord-335975-m6lkrehi 518 30 0.01 0.01 CD cord-335975-m6lkrehi 518 31 ) ) -RRB- cord-335975-m6lkrehi 518 32 . . . cord-335975-m6lkrehi 519 1 Adequate adequate JJ cord-335975-m6lkrehi 519 2 concentrations concentration NNS cord-335975-m6lkrehi 519 3 were be VBD cord-335975-m6lkrehi 519 4 associated associate VBN cord-335975-m6lkrehi 519 5 with with IN cord-335975-m6lkrehi 519 6 small small JJ cord-335975-m6lkrehi 519 7 age age NN cord-335975-m6lkrehi 519 8 ( ( -LRB- cord-335975-m6lkrehi 519 9 p p NN cord-335975-m6lkrehi 519 10 = = SYM cord-335975-m6lkrehi 519 11 0.048 0.048 CD cord-335975-m6lkrehi 519 12 ) ) -RRB- cord-335975-m6lkrehi 519 13 . . . cord-335975-m6lkrehi 520 1 In in IN cord-335975-m6lkrehi 520 2 conclusion conclusion NN cord-335975-m6lkrehi 520 3 , , , cord-335975-m6lkrehi 520 4 current current JJ cord-335975-m6lkrehi 520 5 standard standard JJ cord-335975-m6lkrehi 520 6 beta beta NN cord-335975-m6lkrehi 520 7 - - HYPH cord-335975-m6lkrehi 520 8 lactam lactam NNS cord-335975-m6lkrehi 520 9 dosing dosing NN cord-335975-m6lkrehi 520 10 in in IN cord-335975-m6lkrehi 520 11 children child NNS cord-335975-m6lkrehi 520 12 with with IN cord-335975-m6lkrehi 520 13 severe severe JJ cord-335975-m6lkrehi 520 14 sepsis sepsis NN cord-335975-m6lkrehi 520 15 or or CC cord-335975-m6lkrehi 520 16 septic septic JJ cord-335975-m6lkrehi 520 17 shock shock NN cord-335975-m6lkrehi 520 18 could could MD cord-335975-m6lkrehi 520 19 be be VB cord-335975-m6lkrehi 520 20 inadequate inadequate JJ cord-335975-m6lkrehi 520 21 to to TO cord-335975-m6lkrehi 520 22 reach reach VB cord-335975-m6lkrehi 520 23 the the DT cord-335975-m6lkrehi 520 24 target target NN cord-335975-m6lkrehi 520 25 concentrations concentration NNS cord-335975-m6lkrehi 520 26 . . . cord-335975-m6lkrehi 521 1 That that DT cord-335975-m6lkrehi 521 2 could could MD cord-335975-m6lkrehi 521 3 lead lead VB cord-335975-m6lkrehi 521 4 to to IN cord-335975-m6lkrehi 521 5 the the DT cord-335975-m6lkrehi 521 6 risk risk NN cord-335975-m6lkrehi 521 7 of of IN cord-335975-m6lkrehi 521 8 clinical clinical JJ cord-335975-m6lkrehi 521 9 and and CC cord-335975-m6lkrehi 521 10 bacteriological bacteriological JJ cord-335975-m6lkrehi 521 11 failures failure NNS cord-335975-m6lkrehi 521 12 as as RB cord-335975-m6lkrehi 521 13 well well RB cord-335975-m6lkrehi 521 14 as as IN cord-335975-m6lkrehi 521 15 the the DT cord-335975-m6lkrehi 521 16 emergence emergence NN cord-335975-m6lkrehi 521 17 of of IN cord-335975-m6lkrehi 521 18 bacterial bacterial JJ cord-335975-m6lkrehi 521 19 resistance resistance NN cord-335975-m6lkrehi 521 20 . . . cord-335975-m6lkrehi 522 1 Further further JJ cord-335975-m6lkrehi 522 2 pharmacokinetic pharmacokinetic JJ cord-335975-m6lkrehi 522 3 studies study NNS cord-335975-m6lkrehi 522 4 are be VBP cord-335975-m6lkrehi 522 5 mandatory mandatory JJ cord-335975-m6lkrehi 522 6 to to TO cord-335975-m6lkrehi 522 7 improve improve VB cord-335975-m6lkrehi 522 8 antibiotic antibiotic JJ cord-335975-m6lkrehi 522 9 therapy therapy NN cord-335975-m6lkrehi 522 10 in in IN cord-335975-m6lkrehi 522 11 this this DT cord-335975-m6lkrehi 522 12 vulnerable vulnerable JJ cord-335975-m6lkrehi 522 13 population population NN cord-335975-m6lkrehi 522 14 . . . cord-335975-m6lkrehi 523 1 Introduction introduction NN cord-335975-m6lkrehi 523 2 : : : cord-335975-m6lkrehi 524 1 Intermittent intermittent JJ cord-335975-m6lkrehi 524 2 hemodialysis hemodialysis NN cord-335975-m6lkrehi 524 3 is be VBZ cord-335975-m6lkrehi 524 4 a a DT cord-335975-m6lkrehi 524 5 key key JJ cord-335975-m6lkrehi 524 6 support support NN cord-335975-m6lkrehi 524 7 therapy therapy NN cord-335975-m6lkrehi 524 8 in in IN cord-335975-m6lkrehi 524 9 ICU ICU NNP cord-335975-m6lkrehi 524 10 . . . cord-335975-m6lkrehi 525 1 Despite despite IN cord-335975-m6lkrehi 525 2 protocol protocol NN cord-335975-m6lkrehi 525 3 - - HYPH cord-335975-m6lkrehi 525 4 based base VBN cord-335975-m6lkrehi 525 5 optimization optimization NN cord-335975-m6lkrehi 525 6 , , , cord-335975-m6lkrehi 525 7 intradialytic intradialytic JJ cord-335975-m6lkrehi 525 8 hemodynamic hemodynamic JJ cord-335975-m6lkrehi 525 9 instability instability NN cord-335975-m6lkrehi 525 10 ( ( -LRB- cord-335975-m6lkrehi 525 11 IHI IHI NNP cord-335975-m6lkrehi 525 12 ) ) -RRB- cord-335975-m6lkrehi 525 13 remains remain VBZ cord-335975-m6lkrehi 525 14 a a DT cord-335975-m6lkrehi 525 15 common common JJ cord-335975-m6lkrehi 525 16 complication complication NN cord-335975-m6lkrehi 525 17 and and CC cord-335975-m6lkrehi 525 18 could could MD cord-335975-m6lkrehi 525 19 account account VB cord-335975-m6lkrehi 525 20 for for IN cord-335975-m6lkrehi 525 21 mortality mortality NN cord-335975-m6lkrehi 525 22 and and CC cord-335975-m6lkrehi 525 23 delayed delay VBN cord-335975-m6lkrehi 525 24 renal renal JJ cord-335975-m6lkrehi 525 25 recovery recovery NN cord-335975-m6lkrehi 525 26 . . . cord-335975-m6lkrehi 526 1 The the DT cord-335975-m6lkrehi 526 2 identification identification NN cord-335975-m6lkrehi 526 3 of of IN cord-335975-m6lkrehi 526 4 patients patient NNS cord-335975-m6lkrehi 526 5 at at IN cord-335975-m6lkrehi 526 6 high high JJ cord-335975-m6lkrehi 526 7 risk risk NN cord-335975-m6lkrehi 526 8 for for IN cord-335975-m6lkrehi 526 9 IHI IHI NNP cord-335975-m6lkrehi 526 10 is be VBZ cord-335975-m6lkrehi 526 11 crucial crucial JJ cord-335975-m6lkrehi 526 12 but but CC cord-335975-m6lkrehi 526 13 remains remain VBZ cord-335975-m6lkrehi 526 14 poorly poorly RB cord-335975-m6lkrehi 526 15 explored explore VBN cord-335975-m6lkrehi 526 16 . . . cord-335975-m6lkrehi 527 1 Our -PRON- PRP$ cord-335975-m6lkrehi 527 2 objective objective NN cord-335975-m6lkrehi 527 3 was be VBD cord-335975-m6lkrehi 527 4 to to TO cord-335975-m6lkrehi 527 5 test test VB cord-335975-m6lkrehi 527 6 whether whether IN cord-335975-m6lkrehi 527 7 tissue tissue NN cord-335975-m6lkrehi 527 8 perfusion perfusion NN cord-335975-m6lkrehi 527 9 parameters parameter NNS cord-335975-m6lkrehi 527 10 assessed assess VBN cord-335975-m6lkrehi 527 11 at at IN cord-335975-m6lkrehi 527 12 the the DT cord-335975-m6lkrehi 527 13 bedside bedside NN cord-335975-m6lkrehi 527 14 ( ( -LRB- cord-335975-m6lkrehi 527 15 mottling mottling NN cord-335975-m6lkrehi 527 16 , , , cord-335975-m6lkrehi 527 17 index index NN cord-335975-m6lkrehi 527 18 capillary capillary JJ cord-335975-m6lkrehi 527 19 refill refill NN cord-335975-m6lkrehi 527 20 time time NN cord-335975-m6lkrehi 527 21 ( ( -LRB- cord-335975-m6lkrehi 527 22 iCRT iCRT NNP cord-335975-m6lkrehi 527 23 ) ) -RRB- cord-335975-m6lkrehi 527 24 , , , cord-335975-m6lkrehi 527 25 and and CC cord-335975-m6lkrehi 527 26 lactate lactate NN cord-335975-m6lkrehi 527 27 ) ) -RRB- cord-335975-m6lkrehi 527 28 predict predict VBP cord-335975-m6lkrehi 527 29 IHI IHI NNP cord-335975-m6lkrehi 527 30 and and CC cord-335975-m6lkrehi 527 31 to to TO cord-335975-m6lkrehi 527 32 develop develop VB cord-335975-m6lkrehi 527 33 and and CC cord-335975-m6lkrehi 527 34 to to TO cord-335975-m6lkrehi 527 35 validate validate VB cord-335975-m6lkrehi 527 36 a a DT cord-335975-m6lkrehi 527 37 predictive predictive JJ cord-335975-m6lkrehi 527 38 score score NN cord-335975-m6lkrehi 527 39 of of IN cord-335975-m6lkrehi 527 40 IHI IHI NNP cord-335975-m6lkrehi 527 41 . . . cord-335975-m6lkrehi 528 1 Patients patient NNS cord-335975-m6lkrehi 528 2 and and CC cord-335975-m6lkrehi 528 3 methods method NNS cord-335975-m6lkrehi 528 4 : : : cord-335975-m6lkrehi 528 5 Prospective prospective JJ cord-335975-m6lkrehi 528 6 observational observational JJ cord-335975-m6lkrehi 528 7 study study NN cord-335975-m6lkrehi 528 8 in in IN cord-335975-m6lkrehi 528 9 a a DT cord-335975-m6lkrehi 528 10 18-bed 18-bed CD cord-335975-m6lkrehi 528 11 medical medical JJ cord-335975-m6lkrehi 528 12 ICU ICU NNP cord-335975-m6lkrehi 528 13 in in IN cord-335975-m6lkrehi 528 14 a a DT cord-335975-m6lkrehi 528 15 tertiary tertiary JJ cord-335975-m6lkrehi 528 16 university university NN cord-335975-m6lkrehi 528 17 hospital hospital NN cord-335975-m6lkrehi 528 18 including include VBG cord-335975-m6lkrehi 528 19 hemodialysis hemodialysis NN cord-335975-m6lkrehi 528 20 sessions session NNS cord-335975-m6lkrehi 528 21 performed perform VBN cord-335975-m6lkrehi 528 22 for for IN cord-335975-m6lkrehi 528 23 acute acute JJ cord-335975-m6lkrehi 528 24 kidney kidney NN cord-335975-m6lkrehi 528 25 injury injury NN cord-335975-m6lkrehi 528 26 . . . cord-335975-m6lkrehi 529 1 Exclusion exclusion NN cord-335975-m6lkrehi 529 2 criteria criterion NNS cord-335975-m6lkrehi 529 3 were be VBD cord-335975-m6lkrehi 529 4 patients patient NNS cord-335975-m6lkrehi 529 5 with with IN cord-335975-m6lkrehi 529 6 dark dark JJ cord-335975-m6lkrehi 529 7 skin skin NN cord-335975-m6lkrehi 529 8 and and CC cord-335975-m6lkrehi 529 9 dialysis dialysis NN cord-335975-m6lkrehi 529 10 performed perform VBN cord-335975-m6lkrehi 529 11 in in IN cord-335975-m6lkrehi 529 12 extreme extreme JJ cord-335975-m6lkrehi 529 13 emergency emergency NN cord-335975-m6lkrehi 529 14 . . . cord-335975-m6lkrehi 530 1 Mean mean JJ cord-335975-m6lkrehi 530 2 arterial arterial JJ cord-335975-m6lkrehi 530 3 pressure pressure NN cord-335975-m6lkrehi 530 4 ( ( -LRB- cord-335975-m6lkrehi 530 5 MAP MAP NNP cord-335975-m6lkrehi 530 6 ) ) -RRB- cord-335975-m6lkrehi 530 7 , , , cord-335975-m6lkrehi 530 8 mottling mottling NN cord-335975-m6lkrehi 530 9 score score NN cord-335975-m6lkrehi 530 10 , , , cord-335975-m6lkrehi 530 11 iCRT icrt JJ cord-335975-m6lkrehi 530 12 , , , cord-335975-m6lkrehi 530 13 and and CC cord-335975-m6lkrehi 530 14 lactate lactate NN cord-335975-m6lkrehi 530 15 were be VBD cord-335975-m6lkrehi 530 16 recorded record VBN cord-335975-m6lkrehi 530 17 just just RB cord-335975-m6lkrehi 530 18 before before IN cord-335975-m6lkrehi 530 19 starting start VBG cord-335975-m6lkrehi 530 20 hemodialysis hemodialysis NN cord-335975-m6lkrehi 530 21 . . . cord-335975-m6lkrehi 531 1 First first JJ cord-335975-m6lkrehi 531 2 episode episode NN cord-335975-m6lkrehi 531 3 of of IN cord-335975-m6lkrehi 531 4 IHI IHI NNP cord-335975-m6lkrehi 531 5 requiring require VBG cord-335975-m6lkrehi 531 6 therapeutic therapeutic JJ cord-335975-m6lkrehi 531 7 intervention intervention NN cord-335975-m6lkrehi 531 8 was be VBD cord-335975-m6lkrehi 531 9 recorded record VBN cord-335975-m6lkrehi 531 10 60 60 CD cord-335975-m6lkrehi 531 11 , , , cord-335975-m6lkrehi 531 12 120 120 CD cord-335975-m6lkrehi 531 13 , , , cord-335975-m6lkrehi 531 14 and and CC cord-335975-m6lkrehi 531 15 240 240 CD cord-335975-m6lkrehi 531 16 min min NN cord-335975-m6lkrehi 531 17 after after IN cord-335975-m6lkrehi 531 18 hemodialysis hemodialysis NN cord-335975-m6lkrehi 531 19 starting starting NN cord-335975-m6lkrehi 531 20 . . . cord-335975-m6lkrehi 532 1 Results result NNS cord-335975-m6lkrehi 532 2 : : : cord-335975-m6lkrehi 533 1 Ninety ninety CD cord-335975-m6lkrehi 533 2 - - HYPH cord-335975-m6lkrehi 533 3 six six CD cord-335975-m6lkrehi 533 4 hemodialysis hemodialysis NN cord-335975-m6lkrehi 533 5 sessions session NNS cord-335975-m6lkrehi 533 6 performed perform VBN cord-335975-m6lkrehi 533 7 in in IN cord-335975-m6lkrehi 533 8 43 43 CD cord-335975-m6lkrehi 533 9 patients patient NNS cord-335975-m6lkrehi 533 10 were be VBD cord-335975-m6lkrehi 533 11 recorded record VBN cord-335975-m6lkrehi 533 12 . . . cord-335975-m6lkrehi 534 1 Half half NN cord-335975-m6lkrehi 534 2 of of IN cord-335975-m6lkrehi 534 3 the the DT cord-335975-m6lkrehi 534 4 patients patient NNS cord-335975-m6lkrehi 534 5 received receive VBD cord-335975-m6lkrehi 534 6 vasopressors vasopressor NNS cord-335975-m6lkrehi 534 7 ( ( -LRB- cord-335975-m6lkrehi 534 8 n n NN cord-335975-m6lkrehi 534 9 = = SYM cord-335975-m6lkrehi 534 10 43 43 CD cord-335975-m6lkrehi 534 11 , , , cord-335975-m6lkrehi 534 12 45 45 CD cord-335975-m6lkrehi 534 13 % % NN cord-335975-m6lkrehi 534 14 ) ) -RRB- cord-335975-m6lkrehi 534 15 . . . cord-335975-m6lkrehi 535 1 IHI IHI NNP cord-335975-m6lkrehi 535 2 occurred occur VBD cord-335975-m6lkrehi 535 3 in in IN cord-335975-m6lkrehi 535 4 22 22 CD cord-335975-m6lkrehi 535 5 ( ( -LRB- cord-335975-m6lkrehi 535 6 23 23 CD cord-335975-m6lkrehi 535 7 % % NN cord-335975-m6lkrehi 535 8 ) ) -RRB- cord-335975-m6lkrehi 535 9 sessions session NNS cord-335975-m6lkrehi 535 10 and and CC cord-335975-m6lkrehi 535 11 was be VBD cord-335975-m6lkrehi 535 12 more more RBR cord-335975-m6lkrehi 535 13 frequent frequent JJ cord-335975-m6lkrehi 535 14 among among IN cord-335975-m6lkrehi 535 15 patients patient NNS cord-335975-m6lkrehi 535 16 receiving receive VBG cord-335975-m6lkrehi 535 17 vasopressors vasopressor NNS cord-335975-m6lkrehi 535 18 ( ( -LRB- cord-335975-m6lkrehi 535 19 42 42 CD cord-335975-m6lkrehi 535 20 vs vs IN cord-335975-m6lkrehi 535 21 7 7 CD cord-335975-m6lkrehi 535 22 % % NN cord-335975-m6lkrehi 535 23 , , , cord-335975-m6lkrehi 535 24 p p NN cord-335975-m6lkrehi 535 25 < < XX cord-335975-m6lkrehi 535 26 0.0001 0.0001 CD cord-335975-m6lkrehi 535 27 ) ) -RRB- cord-335975-m6lkrehi 535 28 . . . cord-335975-m6lkrehi 536 1 Mottling mottle VBG cord-335975-m6lkrehi 536 2 were be VBD cord-335975-m6lkrehi 536 3 more more RBR cord-335975-m6lkrehi 536 4 frequent frequent JJ cord-335975-m6lkrehi 536 5 ( ( -LRB- cord-335975-m6lkrehi 536 6 59 59 CD cord-335975-m6lkrehi 536 7 vs vs IN cord-335975-m6lkrehi 536 8 26 26 CD cord-335975-m6lkrehi 536 9 % % NN cord-335975-m6lkrehi 536 10 , , , cord-335975-m6lkrehi 536 11 p p NN cord-335975-m6lkrehi 536 12 = = SYM cord-335975-m6lkrehi 536 13 0.005 0.005 CD cord-335975-m6lkrehi 536 14 ) ) -RRB- cord-335975-m6lkrehi 536 15 , , , cord-335975-m6lkrehi 536 16 lactate lactate NN cord-335975-m6lkrehi 536 17 levels level NNS cord-335975-m6lkrehi 536 18 higher high JJR cord-335975-m6lkrehi 536 19 ( ( -LRB- cord-335975-m6lkrehi 536 20 2.8 2.8 CD cord-335975-m6lkrehi 536 21 [ [ -LRB- cord-335975-m6lkrehi 536 22 1.4 1.4 CD cord-335975-m6lkrehi 536 23 - - SYM cord-335975-m6lkrehi 536 24 6.9 6.9 CD cord-335975-m6lkrehi 536 25 ] ] -RRB- cord-335975-m6lkrehi 536 26 vs vs IN cord-335975-m6lkrehi 537 1 1 1 LS cord-335975-m6lkrehi 537 2 . . . cord-335975-m6lkrehi 537 3 1 1 CD cord-335975-m6lkrehi 538 1 [ [ -LRB- cord-335975-m6lkrehi 538 2 0.8 0.8 CD cord-335975-m6lkrehi 538 3 - - SYM cord-335975-m6lkrehi 538 4 1.5 1.5 CD cord-335975-m6lkrehi 538 5 ] ] -RRB- cord-335975-m6lkrehi 538 6 mmol mmol JJ cord-335975-m6lkrehi 538 7 L l NN cord-335975-m6lkrehi 538 8 , , , cord-335975-m6lkrehi 538 9 p p NN cord-335975-m6lkrehi 538 10 < < XX cord-335975-m6lkrehi 538 11 0.0001 0.0001 CD cord-335975-m6lkrehi 538 12 ) ) -RRB- cord-335975-m6lkrehi 538 13 and and CC cord-335975-m6lkrehi 538 14 iCRT icrt JJ cord-335975-m6lkrehi 538 15 longer long RBR cord-335975-m6lkrehi 538 16 ( ( -LRB- cord-335975-m6lkrehi 538 17 3.3 3.3 CD cord-335975-m6lkrehi 538 18 [ [ -LRB- cord-335975-m6lkrehi 538 19 1.6 1.6 CD cord-335975-m6lkrehi 538 20 - - SYM cord-335975-m6lkrehi 538 21 4.6 4.6 CD cord-335975-m6lkrehi 538 22 ] ] -RRB- cord-335975-m6lkrehi 538 23 vs vs IN cord-335975-m6lkrehi 538 24 1.1 1.1 CD cord-335975-m6lkrehi 538 25 [ [ -LRB- cord-335975-m6lkrehi 538 26 0.8 0.8 CD cord-335975-m6lkrehi 538 27 - - SYM cord-335975-m6lkrehi 538 28 2.0 2.0 CD cord-335975-m6lkrehi 538 29 ] ] -RRB- cord-335975-m6lkrehi 538 30 s s NN cord-335975-m6lkrehi 538 31 , , , cord-335975-m6lkrehi 538 32 p p NN cord-335975-m6lkrehi 538 33 < < XX cord-335975-m6lkrehi 538 34 0.0001 0.0001 CD cord-335975-m6lkrehi 538 35 ) ) -RRB- cord-335975-m6lkrehi 539 1 before before IN cord-335975-m6lkrehi 539 2 sessions session NNS cord-335975-m6lkrehi 539 3 with with IN cord-335975-m6lkrehi 539 4 IHI IHI NNP cord-335975-m6lkrehi 539 5 compared compare VBN cord-335975-m6lkrehi 539 6 to to IN cord-335975-m6lkrehi 539 7 sessions session NNS cord-335975-m6lkrehi 539 8 without without IN cord-335975-m6lkrehi 539 9 , , , cord-335975-m6lkrehi 539 10 independently independently RB cord-335975-m6lkrehi 539 11 of of IN cord-335975-m6lkrehi 539 12 MAP MAP NNP cord-335975-m6lkrehi 539 13 ( ( -LRB- cord-335975-m6lkrehi 539 14 p p NN cord-335975-m6lkrehi 539 15 < < XX cord-335975-m6lkrehi 539 16 0.0001 0.0001 CD cord-335975-m6lkrehi 539 17 ) ) -RRB- cord-335975-m6lkrehi 539 18 . . . cord-335975-m6lkrehi 540 1 The the DT cord-335975-m6lkrehi 540 2 incidence incidence NN cord-335975-m6lkrehi 540 3 of of IN cord-335975-m6lkrehi 540 4 IHI IHI NNP cord-335975-m6lkrehi 540 5 increased increase VBD cord-335975-m6lkrehi 540 6 with with IN cord-335975-m6lkrehi 540 7 the the DT cord-335975-m6lkrehi 540 8 number number NN cord-335975-m6lkrehi 540 9 of of IN cord-335975-m6lkrehi 540 10 tissue tissue NN cord-335975-m6lkrehi 540 11 perfusion perfusion NN cord-335975-m6lkrehi 540 12 alterations alteration NNS cord-335975-m6lkrehi 540 13 ( ( -LRB- cord-335975-m6lkrehi 540 14 3 3 CD cord-335975-m6lkrehi 540 15 , , , cord-335975-m6lkrehi 540 16 11 11 CD cord-335975-m6lkrehi 540 17 , , , cord-335975-m6lkrehi 540 18 41 41 CD cord-335975-m6lkrehi 540 19 , , , cord-335975-m6lkrehi 540 20 and and CC cord-335975-m6lkrehi 540 21 55 55 CD cord-335975-m6lkrehi 540 22 % % NN cord-335975-m6lkrehi 540 23 for for IN cord-335975-m6lkrehi 540 24 0 0 CD cord-335975-m6lkrehi 540 25 , , , cord-335975-m6lkrehi 540 26 1 1 CD cord-335975-m6lkrehi 540 27 , , , cord-335975-m6lkrehi 540 28 2 2 CD cord-335975-m6lkrehi 540 29 , , , cord-335975-m6lkrehi 540 30 and and CC cord-335975-m6lkrehi 540 31 3 3 CD cord-335975-m6lkrehi 540 32 alterations alteration NNS cord-335975-m6lkrehi 540 33 , , , cord-335975-m6lkrehi 540 34 respectively respectively RB cord-335975-m6lkrehi 540 35 , , , cord-335975-m6lkrehi 540 36 p p NN cord-335975-m6lkrehi 540 37 < < XX cord-335975-m6lkrehi 540 38 0.0001 0.0001 CD cord-335975-m6lkrehi 540 39 ) ) -RRB- cord-335975-m6lkrehi 540 40 . . . cord-335975-m6lkrehi 541 1 A a DT cord-335975-m6lkrehi 541 2 tissue tissue NN cord-335975-m6lkrehi 541 3 hypoperfusion hypoperfusion NN cord-335975-m6lkrehi 541 4 score score NN cord-335975-m6lkrehi 541 5 , , , cord-335975-m6lkrehi 541 6 defined define VBN cord-335975-m6lkrehi 541 7 as as IN cord-335975-m6lkrehi 541 8 iCRT iCRT NNP cord-335975-m6lkrehi 541 9 ( ( -LRB- cord-335975-m6lkrehi 541 10 seconds second NNS cord-335975-m6lkrehi 541 11 ) ) -RRB- cord-335975-m6lkrehi 541 12 + + CC cord-335975-m6lkrehi 541 13 lactate lactate NN cord-335975-m6lkrehi 541 14 level level NN cord-335975-m6lkrehi 541 15 ( ( -LRB- cord-335975-m6lkrehi 541 16 mmol mmol JJ cord-335975-m6lkrehi 541 17 L l NN cord-335975-m6lkrehi 541 18 ) ) -RRB- cord-335975-m6lkrehi 542 1 + + SYM cord-335975-m6lkrehi 542 2 1 1 CD cord-335975-m6lkrehi 542 3 if if IN cord-335975-m6lkrehi 542 4 mottling mottle VBG cord-335975-m6lkrehi 542 5 presence presence NN cord-335975-m6lkrehi 542 6 was be VBD cord-335975-m6lkrehi 542 7 predictive predictive JJ cord-335975-m6lkrehi 542 8 of of IN cord-335975-m6lkrehi 542 9 IHI IHI NNP cord-335975-m6lkrehi 542 10 independently independently RB cord-335975-m6lkrehi 542 11 of of IN cord-335975-m6lkrehi 542 12 MAP MAP NNP cord-335975-m6lkrehi 542 13 ( ( -LRB- cord-335975-m6lkrehi 542 14 OR or NN cord-335975-m6lkrehi 542 15 1.18 1.18 CD cord-335975-m6lkrehi 542 16 [ [ -LRB- cord-335975-m6lkrehi 542 17 1.05 1.05 CD cord-335975-m6lkrehi 542 18 - - SYM cord-335975-m6lkrehi 542 19 1.32 1.32 CD cord-335975-m6lkrehi 542 20 Introduction introduction NN cord-335975-m6lkrehi 542 21 : : : cord-335975-m6lkrehi 542 22 Epidemiological epidemiological JJ cord-335975-m6lkrehi 542 23 data datum NNS cord-335975-m6lkrehi 542 24 suggest suggest VBP cord-335975-m6lkrehi 542 25 an an DT cord-335975-m6lkrehi 542 26 increased increase VBN cord-335975-m6lkrehi 542 27 risk risk NN cord-335975-m6lkrehi 542 28 of of IN cord-335975-m6lkrehi 542 29 longterm longterm JJ cord-335975-m6lkrehi 542 30 chronic chronic JJ cord-335975-m6lkrehi 542 31 kidney kidney NN cord-335975-m6lkrehi 542 32 disease disease NN cord-335975-m6lkrehi 542 33 after after IN cord-335975-m6lkrehi 542 34 acute acute JJ cord-335975-m6lkrehi 542 35 kidney kidney NN cord-335975-m6lkrehi 542 36 injury injury NN cord-335975-m6lkrehi 542 37 ( ( -LRB- cord-335975-m6lkrehi 542 38 AKI AKI NNP cord-335975-m6lkrehi 542 39 ) ) -RRB- cord-335975-m6lkrehi 542 40 . . . cord-335975-m6lkrehi 543 1 In in IN cord-335975-m6lkrehi 543 2 survivors survivor NNS cord-335975-m6lkrehi 543 3 of of IN cord-335975-m6lkrehi 543 4 out out IN cord-335975-m6lkrehi 543 5 - - HYPH cord-335975-m6lkrehi 543 6 of of IN cord-335975-m6lkrehi 543 7 - - HYPH cord-335975-m6lkrehi 543 8 hospital hospital NN cord-335975-m6lkrehi 543 9 cardiac cardiac JJ cord-335975-m6lkrehi 543 10 arrest arrest NN cord-335975-m6lkrehi 543 11 ( ( -LRB- cord-335975-m6lkrehi 543 12 OHCA OHCA NNP cord-335975-m6lkrehi 543 13 ) ) -RRB- cord-335975-m6lkrehi 543 14 , , , cord-335975-m6lkrehi 543 15 AKI AKI NNP cord-335975-m6lkrehi 543 16 is be VBZ cord-335975-m6lkrehi 543 17 frequent frequent JJ cord-335975-m6lkrehi 543 18 and and CC cord-335975-m6lkrehi 543 19 is be VBZ cord-335975-m6lkrehi 543 20 associated associate VBN cord-335975-m6lkrehi 543 21 with with IN cord-335975-m6lkrehi 543 22 numerous numerous JJ cord-335975-m6lkrehi 543 23 factors factor NNS cord-335975-m6lkrehi 543 24 of of IN cord-335975-m6lkrehi 543 25 definitive definitive JJ cord-335975-m6lkrehi 543 26 renal renal JJ cord-335975-m6lkrehi 543 27 injury injury NN cord-335975-m6lkrehi 543 28 . . . cord-335975-m6lkrehi 544 1 We -PRON- PRP cord-335975-m6lkrehi 544 2 made make VBD cord-335975-m6lkrehi 544 3 the the DT cord-335975-m6lkrehi 544 4 hypothesis hypothesis NN cord-335975-m6lkrehi 544 5 that that IN cord-335975-m6lkrehi 544 6 AKI AKI NNP cord-335975-m6lkrehi 544 7 after after IN cord-335975-m6lkrehi 544 8 OHCA OHCA NNP cord-335975-m6lkrehi 544 9 was be VBD cord-335975-m6lkrehi 544 10 a a DT cord-335975-m6lkrehi 544 11 strong strong JJ cord-335975-m6lkrehi 544 12 risk risk NN cord-335975-m6lkrehi 544 13 factor factor NN cord-335975-m6lkrehi 544 14 of of IN cord-335975-m6lkrehi 544 15 long long JJ cord-335975-m6lkrehi 544 16 - - HYPH cord-335975-m6lkrehi 544 17 term term NN cord-335975-m6lkrehi 544 18 chronic chronic JJ cord-335975-m6lkrehi 544 19 kidney kidney NN cord-335975-m6lkrehi 544 20 disease disease NN cord-335975-m6lkrehi 544 21 ( ( -LRB- cord-335975-m6lkrehi 544 22 CKD CKD NNP cord-335975-m6lkrehi 544 23 ) ) -RRB- cord-335975-m6lkrehi 544 24 . . . cord-335975-m6lkrehi 545 1 We -PRON- PRP cord-335975-m6lkrehi 545 2 aimed aim VBD cord-335975-m6lkrehi 545 3 to to TO cord-335975-m6lkrehi 545 4 evaluate evaluate VB cord-335975-m6lkrehi 545 5 renal renal JJ cord-335975-m6lkrehi 545 6 outcome outcome NN cord-335975-m6lkrehi 545 7 of of IN cord-335975-m6lkrehi 545 8 OHCA OHCA NNP cord-335975-m6lkrehi 545 9 survivors survivor NNS cord-335975-m6lkrehi 545 10 according accord VBG cord-335975-m6lkrehi 545 11 the the DT cord-335975-m6lkrehi 545 12 occurrence occurrence NN cord-335975-m6lkrehi 545 13 of of IN cord-335975-m6lkrehi 545 14 AKI AKI NNP cord-335975-m6lkrehi 545 15 in in IN cord-335975-m6lkrehi 545 16 ICU ICU NNP cord-335975-m6lkrehi 545 17 . . . cord-335975-m6lkrehi 546 1 Patients patient NNS cord-335975-m6lkrehi 546 2 and and CC cord-335975-m6lkrehi 546 3 methods method NNS cord-335975-m6lkrehi 547 1 : : : cord-335975-m6lkrehi 547 2 We -PRON- PRP cord-335975-m6lkrehi 547 3 used use VBD cord-335975-m6lkrehi 547 4 the the DT cord-335975-m6lkrehi 547 5 cohort cohort NN cord-335975-m6lkrehi 547 6 of of IN cord-335975-m6lkrehi 547 7 consecutive consecutive JJ cord-335975-m6lkrehi 547 8 OHCA OHCA NNP cord-335975-m6lkrehi 547 9 patients patient NNS cord-335975-m6lkrehi 547 10 admitted admit VBN cord-335975-m6lkrehi 547 11 between between IN cord-335975-m6lkrehi 547 12 2007 2007 CD cord-335975-m6lkrehi 547 13 and and CC cord-335975-m6lkrehi 547 14 2012 2012 CD cord-335975-m6lkrehi 547 15 in in IN cord-335975-m6lkrehi 547 16 a a DT cord-335975-m6lkrehi 547 17 tertiary tertiary JJ cord-335975-m6lkrehi 547 18 medical medical JJ cord-335975-m6lkrehi 547 19 ICU ICU NNP cord-335975-m6lkrehi 547 20 previously previously RB cord-335975-m6lkrehi 547 21 described describe VBD cord-335975-m6lkrehi 547 22 ( ( -LRB- cord-335975-m6lkrehi 547 23 Geri Geri NNP cord-335975-m6lkrehi 547 24 et et NNP cord-335975-m6lkrehi 547 25 al al NNP cord-335975-m6lkrehi 547 26 . . . cord-335975-m6lkrehi 548 1 ICM ICM NNP cord-335975-m6lkrehi 548 2 . . . cord-335975-m6lkrehi 548 3 2015 2015 CD cord-335975-m6lkrehi 548 4 ) ) -RRB- cord-335975-m6lkrehi 548 5 . . . cord-335975-m6lkrehi 549 1 AKI AKI NNP cord-335975-m6lkrehi 549 2 was be VBD cord-335975-m6lkrehi 549 3 defined define VBN cord-335975-m6lkrehi 549 4 by by IN cord-335975-m6lkrehi 549 5 Kidney Kidney NNP cord-335975-m6lkrehi 549 6 Disease Disease NNP cord-335975-m6lkrehi 549 7 Improving Improving NNP cord-335975-m6lkrehi 549 8 Global Global NNP cord-335975-m6lkrehi 549 9 Outcomes Outcomes NNPS cord-335975-m6lkrehi 549 10 ( ( -LRB- cord-335975-m6lkrehi 549 11 KDIGO KDIGO NNP cord-335975-m6lkrehi 549 12 ) ) -RRB- cord-335975-m6lkrehi 549 13 criteria criterion NNS cord-335975-m6lkrehi 549 14 . . . cord-335975-m6lkrehi 550 1 Long long JJ cord-335975-m6lkrehi 550 2 - - HYPH cord-335975-m6lkrehi 550 3 term term NN cord-335975-m6lkrehi 550 4 creatinine creatinine NN cord-335975-m6lkrehi 550 5 level level NN cord-335975-m6lkrehi 550 6 was be VBD cord-335975-m6lkrehi 550 7 the the DT cord-335975-m6lkrehi 550 8 last last JJ cord-335975-m6lkrehi 550 9 blood blood NN cord-335975-m6lkrehi 550 10 creatinine creatinine NN cord-335975-m6lkrehi 550 11 assessment assessment NN cord-335975-m6lkrehi 550 12 we -PRON- PRP cord-335975-m6lkrehi 550 13 were be VBD cord-335975-m6lkrehi 550 14 able able JJ cord-335975-m6lkrehi 550 15 to to TO cord-335975-m6lkrehi 550 16 retrieve retrieve VB cord-335975-m6lkrehi 550 17 . . . cord-335975-m6lkrehi 551 1 The the DT cord-335975-m6lkrehi 551 2 main main JJ cord-335975-m6lkrehi 551 3 outcome outcome NN cord-335975-m6lkrehi 551 4 was be VBD cord-335975-m6lkrehi 551 5 the the DT cord-335975-m6lkrehi 551 6 occurrence occurrence NN cord-335975-m6lkrehi 551 7 of of IN cord-335975-m6lkrehi 551 8 CKD CKD NNP cord-335975-m6lkrehi 551 9 , , , cord-335975-m6lkrehi 551 10 defined define VBN cord-335975-m6lkrehi 551 11 by by IN cord-335975-m6lkrehi 551 12 an an DT cord-335975-m6lkrehi 551 13 estimated estimate VBN cord-335975-m6lkrehi 551 14 glomerular glomerular JJ cord-335975-m6lkrehi 551 15 filtration filtration NN cord-335975-m6lkrehi 551 16 rate rate NN cord-335975-m6lkrehi 551 17 ( ( -LRB- cord-335975-m6lkrehi 551 18 eGFR egfr NN cord-335975-m6lkrehi 551 19 ) ) -RRB- cord-335975-m6lkrehi 551 20 lower low JJR cord-335975-m6lkrehi 551 21 than than IN cord-335975-m6lkrehi 551 22 60 60 CD cord-335975-m6lkrehi 551 23 mL ml NN cord-335975-m6lkrehi 551 24 min min NN cord-335975-m6lkrehi 551 25 1.73 1.73 CD cord-335975-m6lkrehi 551 26 m m CD cord-335975-m6lkrehi 551 27 2 2 CD cord-335975-m6lkrehi 551 28 according accord VBG cord-335975-m6lkrehi 551 29 to to IN cord-335975-m6lkrehi 551 30 the the DT cord-335975-m6lkrehi 551 31 MDRD MDRD NNP cord-335975-m6lkrehi 551 32 equation equation NN cord-335975-m6lkrehi 551 33 . . . cord-335975-m6lkrehi 552 1 Long long JJ cord-335975-m6lkrehi 552 2 - - HYPH cord-335975-m6lkrehi 552 3 term term NN cord-335975-m6lkrehi 552 4 mortality mortality NN cord-335975-m6lkrehi 552 5 was be VBD cord-335975-m6lkrehi 552 6 evaluated evaluate VBN cord-335975-m6lkrehi 552 7 as as RB cord-335975-m6lkrehi 552 8 well well RB cord-335975-m6lkrehi 552 9 . . . cord-335975-m6lkrehi 553 1 Factors factor NNS cord-335975-m6lkrehi 553 2 associated associate VBN cord-335975-m6lkrehi 553 3 with with IN cord-335975-m6lkrehi 553 4 CKD CKD NNP cord-335975-m6lkrehi 553 5 occurrence occurrence NN cord-335975-m6lkrehi 553 6 were be VBD cord-335975-m6lkrehi 553 7 evaluated evaluate VBN cord-335975-m6lkrehi 553 8 by by IN cord-335975-m6lkrehi 553 9 competing compete VBG cord-335975-m6lkrehi 553 10 risk risk NN cord-335975-m6lkrehi 553 11 survival survival NN cord-335975-m6lkrehi 553 12 analysis analysis NN cord-335975-m6lkrehi 554 1 ( ( -LRB- cord-335975-m6lkrehi 554 2 Fine Fine NNP cord-335975-m6lkrehi 554 3 Gray Gray NNP cord-335975-m6lkrehi 554 4 and and CC cord-335975-m6lkrehi 554 5 Cox Cox NNP cord-335975-m6lkrehi 554 6 cause cause VBP cord-335975-m6lkrehi 554 7 specific specific JJ cord-335975-m6lkrehi 554 8 models model NNS cord-335975-m6lkrehi 554 9 providing provide VBG cord-335975-m6lkrehi 554 10 sub sub JJ cord-335975-m6lkrehi 554 11 - - JJ cord-335975-m6lkrehi 554 12 hazard hazard NN cord-335975-m6lkrehi 554 13 ratio ratio NN cord-335975-m6lkrehi 554 14 ( ( -LRB- cord-335975-m6lkrehi 554 15 sHR shr CD cord-335975-m6lkrehi 554 16 ) ) -RRB- cord-335975-m6lkrehi 554 17 and and CC cord-335975-m6lkrehi 554 18 Cox Cox NNP cord-335975-m6lkrehi 554 19 sub sub NN cord-335975-m6lkrehi 554 20 - - JJ cord-335975-m6lkrehi 554 21 hazard hazard NN cord-335975-m6lkrehi 554 22 ( ( -LRB- cord-335975-m6lkrehi 554 23 CSH CSH NNP cord-335975-m6lkrehi 554 24 ) ) -RRB- cord-335975-m6lkrehi 554 25 ) ) -RRB- cord-335975-m6lkrehi 554 26 . . . cord-335975-m6lkrehi 555 1 Results result NNS cord-335975-m6lkrehi 555 2 : : : cord-335975-m6lkrehi 556 1 Among among IN cord-335975-m6lkrehi 556 2 the the DT cord-335975-m6lkrehi 556 3 246 246 CD cord-335975-m6lkrehi 556 4 OHCA OHCA NNP cord-335975-m6lkrehi 556 5 patients patient NNS cord-335975-m6lkrehi 556 6 who who WP cord-335975-m6lkrehi 556 7 were be VBD cord-335975-m6lkrehi 556 8 discharged discharge VBN cord-335975-m6lkrehi 556 9 alive alive JJ cord-335975-m6lkrehi 556 10 , , , cord-335975-m6lkrehi 556 11 we -PRON- PRP cord-335975-m6lkrehi 556 12 were be VBD cord-335975-m6lkrehi 556 13 able able JJ cord-335975-m6lkrehi 556 14 to to TO cord-335975-m6lkrehi 556 15 retrieve retrieve VB cord-335975-m6lkrehi 556 16 the the DT cord-335975-m6lkrehi 556 17 outcome outcome NN cord-335975-m6lkrehi 556 18 of of IN cord-335975-m6lkrehi 556 19 133 133 CD cord-335975-m6lkrehi 556 20 patients patient NNS cord-335975-m6lkrehi 556 21 ( ( -LRB- cord-335975-m6lkrehi 556 22 median median JJ cord-335975-m6lkrehi 556 23 age age NN cord-335975-m6lkrehi 556 24 55 55 CD cord-335975-m6lkrehi 556 25 [ [ -LRB- cord-335975-m6lkrehi 556 26 iqr iqr NNP cord-335975-m6lkrehi 556 27 46 46 CD cord-335975-m6lkrehi 556 28 , , , cord-335975-m6lkrehi 556 29 68 68 CD cord-335975-m6lkrehi 556 30 ] ] -RRB- cord-335975-m6lkrehi 556 31 , , , cord-335975-m6lkrehi 556 32 75.2 75.2 CD cord-335975-m6lkrehi 556 33 % % NN cord-335975-m6lkrehi 556 34 of of IN cord-335975-m6lkrehi 556 35 male male NN cord-335975-m6lkrehi 556 36 ) ) -RRB- cord-335975-m6lkrehi 556 37 who who WP cord-335975-m6lkrehi 556 38 were be VBD cord-335975-m6lkrehi 556 39 included include VBN cord-335975-m6lkrehi 556 40 in in IN cord-335975-m6lkrehi 556 41 the the DT cord-335975-m6lkrehi 556 42 analysis analysis NN cord-335975-m6lkrehi 556 43 . . . cord-335975-m6lkrehi 557 1 During during IN cord-335975-m6lkrehi 557 2 a a DT cord-335975-m6lkrehi 557 3 median median JJ cord-335975-m6lkrehi 557 4 follow follow NN cord-335975-m6lkrehi 557 5 - - HYPH cord-335975-m6lkrehi 557 6 up up NN cord-335975-m6lkrehi 557 7 time time NN cord-335975-m6lkrehi 557 8 of of IN cord-335975-m6lkrehi 557 9 1.8 1.8 CD cord-335975-m6lkrehi 557 10 [ [ -LRB- cord-335975-m6lkrehi 557 11 0.8 0.8 CD cord-335975-m6lkrehi 557 12 - - SYM cord-335975-m6lkrehi 557 13 2.5 2.5 CD cord-335975-m6lkrehi 557 14 ] ] -RRB- cord-335975-m6lkrehi 557 15 years year NNS cord-335975-m6lkrehi 557 16 , , , cord-335975-m6lkrehi 557 17 CKD CKD NNP cord-335975-m6lkrehi 557 18 occurred occur VBD cord-335975-m6lkrehi 557 19 in in IN cord-335975-m6lkrehi 557 20 17 17 CD cord-335975-m6lkrehi 557 21 ( ( -LRB- cord-335975-m6lkrehi 557 22 12.7 12.7 CD cord-335975-m6lkrehi 557 23 % % NN cord-335975-m6lkrehi 557 24 ) ) -RRB- cord-335975-m6lkrehi 557 25 patients patient NNS cord-335975-m6lkrehi 557 26 and and CC cord-335975-m6lkrehi 557 27 24 24 CD cord-335975-m6lkrehi 557 28 ( ( -LRB- cord-335975-m6lkrehi 557 29 18 18 CD cord-335975-m6lkrehi 557 30 % % NN cord-335975-m6lkrehi 557 31 ) ) -RRB- cord-335975-m6lkrehi 557 32 patients patient NNS cord-335975-m6lkrehi 557 33 died die VBD cord-335975-m6lkrehi 557 34 . . . cord-335975-m6lkrehi 558 1 A a DT cord-335975-m6lkrehi 558 2 previous previous JJ cord-335975-m6lkrehi 558 3 history history NN cord-335975-m6lkrehi 558 4 of of IN cord-335975-m6lkrehi 558 5 arterial arterial JJ cord-335975-m6lkrehi 558 6 hypertension hypertension NN cord-335975-m6lkrehi 558 7 ( ( -LRB- cord-335975-m6lkrehi 558 8 sHR shr NN cord-335975-m6lkrehi 558 9 = = SYM cord-335975-m6lkrehi 558 10 3.28 3.28 CD cord-335975-m6lkrehi 558 11 [ [ -LRB- cord-335975-m6lkrehi 558 12 1.15 1.15 CD cord-335975-m6lkrehi 558 13 + + SYM cord-335975-m6lkrehi 558 14 9 9 CD cord-335975-m6lkrehi 558 15 .39 .39 CD cord-335975-m6lkrehi 558 16 ] ] -RRB- cord-335975-m6lkrehi 558 17 , , , cord-335975-m6lkrehi 558 18 p p NN cord-335975-m6lkrehi 558 19 = = SYM cord-335975-m6lkrehi 558 20 0.027 0.027 CD cord-335975-m6lkrehi 558 21 + + CC cord-335975-m6lkrehi 558 22 CSH csh NN cord-335975-m6lkrehi 558 23 = = SYM cord-335975-m6lkrehi 558 24 4.83 4.83 CD cord-335975-m6lkrehi 558 25 [ [ -LRB- cord-335975-m6lkrehi 558 26 1.57 1.57 CD cord-335975-m6lkrehi 558 27 + + SYM cord-335975-m6lkrehi 558 28 14.9 14.9 CD cord-335975-m6lkrehi 558 29 ] ] -RRB- cord-335975-m6lkrehi 558 30 , , , cord-335975-m6lkrehi 558 31 p p NN cord-335975-m6lkrehi 558 32 = = SYM cord-335975-m6lkrehi 558 33 0.006 0.006 CD cord-335975-m6lkrehi 558 34 ) ) -RRB- cord-335975-m6lkrehi 558 35 , , , cord-335975-m6lkrehi 558 36 AKI AKI NNP cord-335975-m6lkrehi 558 37 during during IN cord-335975-m6lkrehi 558 38 ICU ICU NNP cord-335975-m6lkrehi 558 39 stay stay NN cord-335975-m6lkrehi 558 40 ( ( -LRB- cord-335975-m6lkrehi 558 41 sHR shr NN cord-335975-m6lkrehi 558 42 = = SYM cord-335975-m6lkrehi 558 43 3.72 3.72 CD cord-335975-m6lkrehi 558 44 [ [ -LRB- cord-335975-m6lkrehi 558 45 1.40 1.40 CD cord-335975-m6lkrehi 558 46 + + SYM cord-335975-m6lkrehi 558 47 9 9 CD cord-335975-m6lkrehi 558 48 .84 .84 CD cord-335975-m6lkrehi 558 49 ] ] -RRB- cord-335975-m6lkrehi 559 1 , , , cord-335975-m6lkrehi 559 2 p p NN cord-335975-m6lkrehi 559 3 = = SYM cord-335975-m6lkrehi 559 4 0.008 0.008 CD cord-335975-m6lkrehi 559 5 + + CC cord-335975-m6lkrehi 559 6 CSH csh NN cord-335975-m6lkrehi 559 7 = = SYM cord-335975-m6lkrehi 559 8 5.41 5.41 CD cord-335975-m6lkrehi 559 9 [ [ -LRB- cord-335975-m6lkrehi 559 10 1.79 1.79 CD cord-335975-m6lkrehi 559 11 + + SYM cord-335975-m6lkrehi 559 12 16.3 16.3 CD cord-335975-m6lkrehi 559 13 ] ] -RRB- cord-335975-m6lkrehi 559 14 , , , cord-335975-m6lkrehi 559 15 p p NN cord-335975-m6lkrehi 559 16 = = SYM cord-335975-m6lkrehi 559 17 0.003 0.003 CD cord-335975-m6lkrehi 559 18 ) ) -RRB- cord-335975-m6lkrehi 559 19 and and CC cord-335975-m6lkrehi 559 20 an an DT cord-335975-m6lkrehi 559 21 age age NN cord-335975-m6lkrehi 559 22 higher high JJR cord-335975-m6lkrehi 559 23 than than IN cord-335975-m6lkrehi 559 24 55 55 CD cord-335975-m6lkrehi 560 1 ( ( -LRB- cord-335975-m6lkrehi 560 2 sHR shr IN cord-335975-m6lkrehi 560 3 = = NFP cord-335975-m6lkrehi 561 1 6.13 6.13 CD cord-335975-m6lkrehi 561 2 [ [ -LRB- cord-335975-m6lkrehi 561 3 1.55 1.55 CD cord-335975-m6lkrehi 561 4 + + SYM cord-335975-m6lkrehi 561 5 24.3 24.3 CD cord-335975-m6lkrehi 561 6 ] ] -RRB- cord-335975-m6lkrehi 562 1 , , , cord-335975-m6lkrehi 562 2 p p NN cord-335975-m6lkrehi 562 3 = = SYM cord-335975-m6lkrehi 562 4 0.009 0.009 CD cord-335975-m6lkrehi 563 1 + + CC cord-335975-m6lkrehi 563 2 CSH csh NN cord-335975-m6lkrehi 563 3 = = SYM cord-335975-m6lkrehi 563 4 2.16 2.16 CD cord-335975-m6lkrehi 563 5 [ [ -LRB- cord-335975-m6lkrehi 563 6 1.72 1.72 CD cord-335975-m6lkrehi 563 7 + + SYM cord-335975-m6lkrehi 563 8 43.8 43.8 CD cord-335975-m6lkrehi 563 9 ] ] -RRB- cord-335975-m6lkrehi 563 10 , , , cord-335975-m6lkrehi 563 11 p p NN cord-335975-m6lkrehi 563 12 = = SYM cord-335975-m6lkrehi 563 13 0.006 0.006 CD cord-335975-m6lkrehi 563 14 ) ) -RRB- cord-335975-m6lkrehi 563 15 were be VBD cord-335975-m6lkrehi 563 16 independently independently RB cord-335975-m6lkrehi 563 17 associated associate VBN cord-335975-m6lkrehi 563 18 with with IN cord-335975-m6lkrehi 563 19 CKD CKD NNP cord-335975-m6lkrehi 563 20 occurrence occurrence NN cord-335975-m6lkrehi 563 21 . . . cord-335975-m6lkrehi 564 1 AKI AKI NNP cord-335975-m6lkrehi 564 2 was be VBD cord-335975-m6lkrehi 564 3 not not RB cord-335975-m6lkrehi 564 4 associated associate VBN cord-335975-m6lkrehi 564 5 with with IN cord-335975-m6lkrehi 564 6 long long JJ cord-335975-m6lkrehi 564 7 - - HYPH cord-335975-m6lkrehi 564 8 term term NN cord-335975-m6lkrehi 564 9 mortality mortality NN cord-335975-m6lkrehi 564 10 ( ( -LRB- cord-335975-m6lkrehi 564 11 sHR shr XX cord-335975-m6lkrehi 564 12 = = SYM cord-335975-m6lkrehi 564 13 0.73 0.73 CD cord-335975-m6lkrehi 564 14 [ [ -LRB- cord-335975-m6lkrehi 564 15 0.27 0.27 CD cord-335975-m6lkrehi 564 16 + + SYM cord-335975-m6lkrehi 564 17 1.99 1.99 CD cord-335975-m6lkrehi 564 18 ] ] -RRB- cord-335975-m6lkrehi 565 1 , , , cord-335975-m6lkrehi 565 2 p p NN cord-335975-m6lkrehi 565 3 = = SYM cord-335975-m6lkrehi 565 4 0.55 0.55 CD cord-335975-m6lkrehi 566 1 + + CC cord-335975-m6lkrehi 566 2 CSH csh NN cord-335975-m6lkrehi 566 3 = = SYM cord-335975-m6lkrehi 566 4 0.75 0.75 CD cord-335975-m6lkrehi 566 5 [ [ -LRB- cord-335975-m6lkrehi 566 6 0.28 0.28 CD cord-335975-m6lkrehi 566 7 + + SYM cord-335975-m6lkrehi 566 8 2.01 2.01 CD cord-335975-m6lkrehi 566 9 ] ] -RRB- cord-335975-m6lkrehi 566 10 , , , cord-335975-m6lkrehi 566 11 p p NN cord-335975-m6lkrehi 566 12 = = SYM cord-335975-m6lkrehi 566 13 0.57 0.57 CD cord-335975-m6lkrehi 566 14 ) ) -RRB- cord-335975-m6lkrehi 566 15 . . . cord-335975-m6lkrehi 567 1 In in IN cord-335975-m6lkrehi 567 2 OHCA OHCA NNP cord-335975-m6lkrehi 567 3 survivors survivor NNS cord-335975-m6lkrehi 567 4 resuscitated resuscitate VBD cord-335975-m6lkrehi 567 5 from from IN cord-335975-m6lkrehi 567 6 an an DT cord-335975-m6lkrehi 567 7 OHCA OHCA NNP cord-335975-m6lkrehi 567 8 , , , cord-335975-m6lkrehi 567 9 CKD CKD NNP cord-335975-m6lkrehi 567 10 was be VBD cord-335975-m6lkrehi 567 11 a a DT cord-335975-m6lkrehi 567 12 frequent frequent JJ cord-335975-m6lkrehi 567 13 long long JJ cord-335975-m6lkrehi 567 14 - - HYPH cord-335975-m6lkrehi 567 15 term term NN cord-335975-m6lkrehi 567 16 complication complication NN cord-335975-m6lkrehi 567 17 . . . cord-335975-m6lkrehi 568 1 AKI AKI NNP cord-335975-m6lkrehi 568 2 during during IN cord-335975-m6lkrehi 568 3 ICU ICU NNP cord-335975-m6lkrehi 568 4 stay stay NN cord-335975-m6lkrehi 568 5 was be VBD cord-335975-m6lkrehi 568 6 a a DT cord-335975-m6lkrehi 568 7 strong strong JJ cord-335975-m6lkrehi 568 8 determinant determinant NN cord-335975-m6lkrehi 568 9 of of IN cord-335975-m6lkrehi 568 10 long long JJ cord-335975-m6lkrehi 568 11 - - HYPH cord-335975-m6lkrehi 568 12 term term NN cord-335975-m6lkrehi 568 13 CKD CKD NNP cord-335975-m6lkrehi 568 14 occurrence occurrence NN cord-335975-m6lkrehi 568 15 . . . cord-335975-m6lkrehi 569 1 Introduction introduction NN cord-335975-m6lkrehi 569 2 : : : cord-335975-m6lkrehi 570 1 Many many JJ cord-335975-m6lkrehi 570 2 critically critically RB cord-335975-m6lkrehi 570 3 ill ill VBP cord-335975-m6lkrehi 570 4 patients patient NNS cord-335975-m6lkrehi 570 5 have have VBP cord-335975-m6lkrehi 570 6 a a DT cord-335975-m6lkrehi 570 7 moderate moderate JJ cord-335975-m6lkrehi 570 8 to to IN cord-335975-m6lkrehi 570 9 high high JJ cord-335975-m6lkrehi 570 10 risk risk NN cord-335975-m6lkrehi 570 11 of of IN cord-335975-m6lkrehi 570 12 bleeding bleed VBG cord-335975-m6lkrehi 570 13 but but CC cord-335975-m6lkrehi 570 14 they -PRON- PRP cord-335975-m6lkrehi 570 15 also also RB cord-335975-m6lkrehi 570 16 require require VBP cord-335975-m6lkrehi 570 17 prolonged prolong VBN cord-335975-m6lkrehi 570 18 intermittent intermittent JJ cord-335975-m6lkrehi 570 19 dialysis dialysis NN cord-335975-m6lkrehi 570 20 to to TO cord-335975-m6lkrehi 570 21 ensure ensure VB cord-335975-m6lkrehi 570 22 a a DT cord-335975-m6lkrehi 570 23 negative negative JJ cord-335975-m6lkrehi 570 24 water water NN cord-335975-m6lkrehi 570 25 balance balance NN cord-335975-m6lkrehi 570 26 without without IN cord-335975-m6lkrehi 570 27 hemodynamic hemodynamic JJ cord-335975-m6lkrehi 570 28 adverse adverse JJ cord-335975-m6lkrehi 570 29 events event NNS cord-335975-m6lkrehi 570 30 . . . cord-335975-m6lkrehi 571 1 Thus thus RB cord-335975-m6lkrehi 571 2 , , , cord-335975-m6lkrehi 571 3 a a DT cord-335975-m6lkrehi 571 4 heparin heparin NN cord-335975-m6lkrehi 571 5 - - HYPH cord-335975-m6lkrehi 571 6 free free JJ cord-335975-m6lkrehi 571 7 easy easy JJ cord-335975-m6lkrehi 571 8 - - HYPH cord-335975-m6lkrehi 571 9 to to TO cord-335975-m6lkrehi 571 10 - - HYPH cord-335975-m6lkrehi 571 11 use use NN cord-335975-m6lkrehi 571 12 anticoagulation anticoagulation NN cord-335975-m6lkrehi 571 13 within within IN cord-335975-m6lkrehi 571 14 the the DT cord-335975-m6lkrehi 571 15 dialysis dialysis NN cord-335975-m6lkrehi 571 16 circuit circuit NN cord-335975-m6lkrehi 571 17 is be VBZ cord-335975-m6lkrehi 571 18 needed need VBN cord-335975-m6lkrehi 571 19 but but CC cord-335975-m6lkrehi 571 20 , , , cord-335975-m6lkrehi 571 21 to to IN cord-335975-m6lkrehi 571 22 date date NN cord-335975-m6lkrehi 571 23 , , , cord-335975-m6lkrehi 571 24 usual usual JJ cord-335975-m6lkrehi 571 25 protocols protocol NNS cord-335975-m6lkrehi 571 26 ( ( -LRB- cord-335975-m6lkrehi 571 27 iterative iterative JJ cord-335975-m6lkrehi 571 28 saline saline NN cord-335975-m6lkrehi 571 29 flushes flush NNS cord-335975-m6lkrehi 571 30 , , , cord-335975-m6lkrehi 571 31 heparin heparin NN cord-335975-m6lkrehi 571 32 grafted graft VBN cord-335975-m6lkrehi 571 33 membranes membrane NNS cord-335975-m6lkrehi 571 34 ) ) -RRB- cord-335975-m6lkrehi 571 35 lead lead VBP cord-335975-m6lkrehi 571 36 to to IN cord-335975-m6lkrehi 571 37 20 20 CD cord-335975-m6lkrehi 571 38 - - SYM cord-335975-m6lkrehi 571 39 50 50 CD cord-335975-m6lkrehi 571 40 % % NN cord-335975-m6lkrehi 571 41 of of IN cord-335975-m6lkrehi 571 42 premature premature JJ cord-335975-m6lkrehi 571 43 clotting clotting NN cord-335975-m6lkrehi 571 44 and and CC cord-335975-m6lkrehi 571 45 sessions session NNS cord-335975-m6lkrehi 572 1 that that DT cord-335975-m6lkrehi 572 2 last last JJ cord-335975-m6lkrehi 572 3 greater great JJR cord-335975-m6lkrehi 572 4 than than IN cord-335975-m6lkrehi 572 5 240 240 CD cord-335975-m6lkrehi 572 6 min min NNS cord-335975-m6lkrehi 572 7 are be VBP cord-335975-m6lkrehi 572 8 rarely rarely RB cord-335975-m6lkrehi 572 9 achievable achievable JJ cord-335975-m6lkrehi 572 10 . . . cord-335975-m6lkrehi 573 1 We -PRON- PRP cord-335975-m6lkrehi 573 2 assessed assess VBD cord-335975-m6lkrehi 573 3 the the DT cord-335975-m6lkrehi 573 4 safety safety NN cord-335975-m6lkrehi 573 5 and and CC cord-335975-m6lkrehi 573 6 efficiency efficiency NN cord-335975-m6lkrehi 573 7 of of IN cord-335975-m6lkrehi 573 8 heparin heparin NN cord-335975-m6lkrehi 573 9 - - HYPH cord-335975-m6lkrehi 573 10 free free JJ cord-335975-m6lkrehi 573 11 regional regional JJ cord-335975-m6lkrehi 573 12 citrate citrate NN cord-335975-m6lkrehi 573 13 anticoagulation anticoagulation NN cord-335975-m6lkrehi 573 14 of of IN cord-335975-m6lkrehi 573 15 the the DT cord-335975-m6lkrehi 573 16 dialysis dialysis NN cord-335975-m6lkrehi 573 17 circuit circuit NN cord-335975-m6lkrehi 573 18 using use VBG cord-335975-m6lkrehi 573 19 a a DT cord-335975-m6lkrehi 573 20 calcium calcium NN cord-335975-m6lkrehi 573 21 - - HYPH cord-335975-m6lkrehi 573 22 free free JJ cord-335975-m6lkrehi 573 23 citrate citrate NN cord-335975-m6lkrehi 573 24 - - HYPH cord-335975-m6lkrehi 573 25 containing contain VBG cord-335975-m6lkrehi 573 26 dialysate dialysate NN cord-335975-m6lkrehi 573 27 , , , cord-335975-m6lkrehi 573 28 with with IN cord-335975-m6lkrehi 573 29 calcium calcium NN cord-335975-m6lkrehi 573 30 reinjected reinjecte VBN cord-335975-m6lkrehi 573 31 according accord VBG cord-335975-m6lkrehi 573 32 to to IN cord-335975-m6lkrehi 573 33 ionic ionic JJ cord-335975-m6lkrehi 573 34 dialysance dialysance NNP cord-335975-m6lkrehi 573 35 ( ( -LRB- cord-335975-m6lkrehi 573 36 an an DT cord-335975-m6lkrehi 573 37 online online JJ cord-335975-m6lkrehi 573 38 measure measure NN cord-335975-m6lkrehi 573 39 of of IN cord-335975-m6lkrehi 573 40 the the DT cord-335975-m6lkrehi 573 41 instantaneous instantaneous JJ cord-335975-m6lkrehi 573 42 clearance clearance NN cord-335975-m6lkrehi 573 43 of of IN cord-335975-m6lkrehi 573 44 small small JJ cord-335975-m6lkrehi 573 45 molecules molecule NNS cord-335975-m6lkrehi 573 46 available available JJ cord-335975-m6lkrehi 573 47 in in IN cord-335975-m6lkrehi 573 48 most most JJS cord-335975-m6lkrehi 573 49 of of IN cord-335975-m6lkrehi 573 50 dialyzers dialyzer NNS cord-335975-m6lkrehi 573 51 ) ) -RRB- cord-335975-m6lkrehi 573 52 . . . cord-335975-m6lkrehi 574 1 Patients patient NNS cord-335975-m6lkrehi 574 2 and and CC cord-335975-m6lkrehi 574 3 methods method NNS cord-335975-m6lkrehi 574 4 : : : cord-335975-m6lkrehi 574 5 We -PRON- PRP cord-335975-m6lkrehi 574 6 prospectively prospectively RB cord-335975-m6lkrehi 574 7 reported report VBD cord-335975-m6lkrehi 574 8 the the DT cord-335975-m6lkrehi 574 9 clotting clotting NN cord-335975-m6lkrehi 574 10 events event NNS cord-335975-m6lkrehi 574 11 that that WDT cord-335975-m6lkrehi 574 12 occurred occur VBD cord-335975-m6lkrehi 574 13 during during IN cord-335975-m6lkrehi 574 14 all all PDT cord-335975-m6lkrehi 574 15 the the DT cord-335975-m6lkrehi 574 16 heparin heparin NN cord-335975-m6lkrehi 574 17 - - HYPH cord-335975-m6lkrehi 574 18 free free JJ cord-335975-m6lkrehi 574 19 dialysis dialysis NN cord-335975-m6lkrehi 574 20 sessions session NNS cord-335975-m6lkrehi 574 21 that that WDT cord-335975-m6lkrehi 574 22 were be VBD cord-335975-m6lkrehi 574 23 performed perform VBN cord-335975-m6lkrehi 574 24 with with IN cord-335975-m6lkrehi 574 25 a a DT cord-335975-m6lkrehi 574 26 regional regional JJ cord-335975-m6lkrehi 574 27 anticoagulation anticoagulation NN cord-335975-m6lkrehi 574 28 based base VBN cord-335975-m6lkrehi 574 29 on on IN cord-335975-m6lkrehi 574 30 calcium calcium NN cord-335975-m6lkrehi 574 31 - - HYPH cord-335975-m6lkrehi 574 32 zero zero CD cord-335975-m6lkrehi 574 33 citrate citrate NN cord-335975-m6lkrehi 574 34 - - HYPH cord-335975-m6lkrehi 574 35 containing contain VBG cord-335975-m6lkrehi 574 36 dialysate dialysate NN cord-335975-m6lkrehi 574 37 ( ( -LRB- cord-335975-m6lkrehi 574 38 Citrasate Citrasate NNP cord-335975-m6lkrehi 574 39 , , , cord-335975-m6lkrehi 574 40 Hemotech Hemotech NNP cord-335975-m6lkrehi 574 41 , , , cord-335975-m6lkrehi 574 42 France France NNP cord-335975-m6lkrehi 574 43 ) ) -RRB- cord-335975-m6lkrehi 574 44 between between IN cord-335975-m6lkrehi 574 45 January January NNP cord-335975-m6lkrehi 574 46 2016 2016 CD cord-335975-m6lkrehi 574 47 and and CC cord-335975-m6lkrehi 574 48 August August NNP cord-335975-m6lkrehi 574 49 2017 2017 CD cord-335975-m6lkrehi 574 50 in in IN cord-335975-m6lkrehi 574 51 a a DT cord-335975-m6lkrehi 574 52 28-beds 28-beds CD cord-335975-m6lkrehi 574 53 ICU ICU NNP cord-335975-m6lkrehi 574 54 . . . cord-335975-m6lkrehi 575 1 Results result NNS cord-335975-m6lkrehi 575 2 : : : cord-335975-m6lkrehi 576 1 A a DT cord-335975-m6lkrehi 576 2 total total NN cord-335975-m6lkrehi 576 3 of of IN cord-335975-m6lkrehi 576 4 186 186 CD cord-335975-m6lkrehi 576 5 dialysis dialysis NN cord-335975-m6lkrehi 576 6 sessions session NNS cord-335975-m6lkrehi 576 7 were be VBD cord-335975-m6lkrehi 576 8 performed perform VBN cord-335975-m6lkrehi 576 9 in in IN cord-335975-m6lkrehi 576 10 70 70 CD cord-335975-m6lkrehi 576 11 patients patient NNS cord-335975-m6lkrehi 576 12 ( ( -LRB- cord-335975-m6lkrehi 576 13 mechanical mechanical JJ cord-335975-m6lkrehi 576 14 ventilation ventilation NN cord-335975-m6lkrehi 576 15 n n CC cord-335975-m6lkrehi 576 16 = = SYM cord-335975-m6lkrehi 576 17 93 93 CD cord-335975-m6lkrehi 576 18 + + CD cord-335975-m6lkrehi 577 1 norepinephrine norepinephrine NNP cord-335975-m6lkrehi 577 2 n n NNP cord-335975-m6lkrehi 577 3 = = SYM cord-335975-m6lkrehi 577 4 20 20 CD cord-335975-m6lkrehi 577 5 ) ) -RRB- cord-335975-m6lkrehi 577 6 . . . cord-335975-m6lkrehi 578 1 Median median JJ cord-335975-m6lkrehi 578 2 duration duration NN cord-335975-m6lkrehi 578 3 of of IN cord-335975-m6lkrehi 578 4 dialysis dialysis NN cord-335975-m6lkrehi 578 5 was be VBD cord-335975-m6lkrehi 578 6 240 240 CD cord-335975-m6lkrehi 578 7 min min NN cord-335975-m6lkrehi 578 8 ( ( -LRB- cord-335975-m6lkrehi 578 9 IQR IQR NNP cord-335975-m6lkrehi 578 10 , , , cord-335975-m6lkrehi 578 11 240 240 CD cord-335975-m6lkrehi 578 12 - - SYM cord-335975-m6lkrehi 578 13 300 300 CD cord-335975-m6lkrehi 578 14 + + SYM cord-335975-m6lkrehi 578 15 maximum maximum JJ cord-335975-m6lkrehi 578 16 360 360 CD cord-335975-m6lkrehi 578 17 min min NN cord-335975-m6lkrehi 578 18 ) ) -RRB- cord-335975-m6lkrehi 578 19 , , , cord-335975-m6lkrehi 578 20 and and CC cord-335975-m6lkrehi 578 21 median median JJ cord-335975-m6lkrehi 578 22 ultrafiltration ultrafiltration NN cord-335975-m6lkrehi 578 23 volume volume NN cord-335975-m6lkrehi 578 24 was be VBD cord-335975-m6lkrehi 578 25 2 2 CD cord-335975-m6lkrehi 578 26 L l NN cord-335975-m6lkrehi 578 27 ( ( -LRB- cord-335975-m6lkrehi 578 28 IQR IQR NNP cord-335975-m6lkrehi 578 29 1 1 CD cord-335975-m6lkrehi 578 30 . . . cord-335975-m6lkrehi 578 31 3 3 CD cord-335975-m6lkrehi 578 32 - - SYM cord-335975-m6lkrehi 578 33 2.6 2.6 CD cord-335975-m6lkrehi 578 34 ) ) -RRB- cord-335975-m6lkrehi 578 35 . . . cord-335975-m6lkrehi 579 1 When when WRB cord-335975-m6lkrehi 579 2 assessed assess VBN cord-335975-m6lkrehi 579 3 , , , cord-335975-m6lkrehi 579 4 urea urea NN cord-335975-m6lkrehi 579 5 and and CC cord-335975-m6lkrehi 579 6 Beta2-microglobulin beta2-microglobulin JJ cord-335975-m6lkrehi 579 7 reduction reduction NN cord-335975-m6lkrehi 579 8 rates rate NNS cord-335975-m6lkrehi 579 9 were be VBD cord-335975-m6lkrehi 579 10 64.5 64.5 CD cord-335975-m6lkrehi 579 11 % % NN cord-335975-m6lkrehi 579 12 ± ± NNP cord-335975-m6lkrehi 579 13 0.4 0.4 CD cord-335975-m6lkrehi 579 14 % % NN cord-335975-m6lkrehi 579 15 and and CC cord-335975-m6lkrehi 579 16 48 48 CD cord-335975-m6lkrehi 579 17 % % NN cord-335975-m6lkrehi 579 18 ± ± CD cord-335975-m6lkrehi 579 19 0.13 0.13 CD cord-335975-m6lkrehi 579 20 % % NN cord-335975-m6lkrehi 579 21 , , , cord-335975-m6lkrehi 579 22 respectively respectively RB cord-335975-m6lkrehi 579 23 . . . cord-335975-m6lkrehi 580 1 Postfilter Postfilter NNP cord-335975-m6lkrehi 580 2 ionized ionized JJ cord-335975-m6lkrehi 580 3 calcium calcium NN cord-335975-m6lkrehi 580 4 was be VBD cord-335975-m6lkrehi 580 5 0.35 0.35 CD cord-335975-m6lkrehi 580 6 ± ± CD cord-335975-m6lkrehi 580 7 0.17 0.17 CD cord-335975-m6lkrehi 580 8 and and CC cord-335975-m6lkrehi 580 9 0.38 0.38 CD cord-335975-m6lkrehi 580 10 ± ± XX cord-335975-m6lkrehi 581 1 0.14 0.14 CD cord-335975-m6lkrehi 581 2 mmol mmol NNP cord-335975-m6lkrehi 581 3 L L NNP cord-335975-m6lkrehi 581 4 at at IN cord-335975-m6lkrehi 581 5 1 1 CD cord-335975-m6lkrehi 581 6 and and CC cord-335975-m6lkrehi 581 7 3 3 CD cord-335975-m6lkrehi 581 8 h h NN cord-335975-m6lkrehi 581 9 , , , cord-335975-m6lkrehi 581 10 respectively respectively RB cord-335975-m6lkrehi 581 11 , , , cord-335975-m6lkrehi 581 12 within within IN cord-335975-m6lkrehi 581 13 the the DT cord-335975-m6lkrehi 581 14 extracorporeal extracorporeal JJ cord-335975-m6lkrehi 581 15 circuit circuit NN cord-335975-m6lkrehi 581 16 . . . cord-335975-m6lkrehi 582 1 A a DT cord-335975-m6lkrehi 582 2 major major JJ cord-335975-m6lkrehi 582 3 clotting clotting NN cord-335975-m6lkrehi 582 4 event event NN cord-335975-m6lkrehi 582 5 that that WDT cord-335975-m6lkrehi 582 6 led lead VBD cord-335975-m6lkrehi 582 7 to to IN cord-335975-m6lkrehi 582 8 premature premature JJ cord-335975-m6lkrehi 582 9 termination termination NN cord-335975-m6lkrehi 582 10 of of IN cord-335975-m6lkrehi 582 11 the the DT cord-335975-m6lkrehi 582 12 session session NN cord-335975-m6lkrehi 582 13 occurred occur VBD cord-335975-m6lkrehi 582 14 in in IN cord-335975-m6lkrehi 582 15 only only JJ cord-335975-m6lkrehi 582 16 5186 5186 CD cord-335975-m6lkrehi 582 17 sessions session NNS cord-335975-m6lkrehi 582 18 ( ( -LRB- cord-335975-m6lkrehi 582 19 2.7 2.7 CD cord-335975-m6lkrehi 582 20 % % NN cord-335975-m6lkrehi 582 21 ) ) -RRB- cord-335975-m6lkrehi 582 22 . . . cord-335975-m6lkrehi 583 1 In in IN cord-335975-m6lkrehi 583 2 these these DT cord-335975-m6lkrehi 583 3 five five CD cord-335975-m6lkrehi 583 4 cases case NNS cord-335975-m6lkrehi 583 5 , , , cord-335975-m6lkrehi 583 6 major major JJ cord-335975-m6lkrehi 583 7 catheter catheter NN cord-335975-m6lkrehi 583 8 dysfunction dysfunction NN cord-335975-m6lkrehi 583 9 occurred occur VBD cord-335975-m6lkrehi 583 10 before before IN cord-335975-m6lkrehi 583 11 clotting clot VBG cord-335975-m6lkrehi 583 12 within within IN cord-335975-m6lkrehi 583 13 the the DT cord-335975-m6lkrehi 583 14 circuit circuit NN cord-335975-m6lkrehi 583 15 . . . cord-335975-m6lkrehi 584 1 Prefilter Prefilter NNP cord-335975-m6lkrehi 584 2 ionized ionized JJ cord-335975-m6lkrehi 584 3 calcium calcium NN cord-335975-m6lkrehi 584 4 remained remain VBD cord-335975-m6lkrehi 584 5 within within IN cord-335975-m6lkrehi 584 6 narrow narrow JJ cord-335975-m6lkrehi 584 7 ranges range NNS cord-335975-m6lkrehi 584 8 ( ( -LRB- cord-335975-m6lkrehi 584 9 before before IN cord-335975-m6lkrehi 584 10 after after IN cord-335975-m6lkrehi 584 11 change change NN cord-335975-m6lkrehi 584 12 +0.07 +0.07 NNP cord-335975-m6lkrehi 584 13 ± ± NNP cord-335975-m6lkrehi 584 14 0.006 0.006 CD cord-335975-m6lkrehi 584 15 mmol mmol JJ cord-335975-m6lkrehi 584 16 L L NNP cord-335975-m6lkrehi 584 17 ) ) -RRB- cord-335975-m6lkrehi 584 18 , , , cord-335975-m6lkrehi 584 19 and and CC cord-335975-m6lkrehi 584 20 total total NN cord-335975-m6lkrehi 584 21 - - HYPH cord-335975-m6lkrehi 584 22 to to IN cord-335975-m6lkrehi 584 23 - - HYPH cord-335975-m6lkrehi 584 24 ionized ionize VBN cord-335975-m6lkrehi 584 25 calcium calcium NN cord-335975-m6lkrehi 584 26 ratio ratio NN cord-335975-m6lkrehi 584 27 , , , cord-335975-m6lkrehi 584 28 a a DT cord-335975-m6lkrehi 584 29 surrogate surrogate JJ cord-335975-m6lkrehi 584 30 marker marker NN cord-335975-m6lkrehi 584 31 for for IN cord-335975-m6lkrehi 584 32 citratemia citratemia NN cord-335975-m6lkrehi 584 33 , , , cord-335975-m6lkrehi 584 34 was be VBD cord-335975-m6lkrehi 584 35 unchanged unchanged JJ cord-335975-m6lkrehi 584 36 and and CC cord-335975-m6lkrehi 584 37 always always RB cord-335975-m6lkrehi 584 38 below below IN cord-335975-m6lkrehi 584 39 2.5 2.5 CD cord-335975-m6lkrehi 584 40 . . . cord-335975-m6lkrehi 585 1 In in IN cord-335975-m6lkrehi 585 2 85 85 CD cord-335975-m6lkrehi 585 3 sessions session NNS cord-335975-m6lkrehi 585 4 , , , cord-335975-m6lkrehi 585 5 no no DT cord-335975-m6lkrehi 585 6 ionized ionized JJ cord-335975-m6lkrehi 585 7 calcium calcium NN cord-335975-m6lkrehi 585 8 measurement measurement NN cord-335975-m6lkrehi 585 9 was be VBD cord-335975-m6lkrehi 585 10 required require VBN cord-335975-m6lkrehi 585 11 . . . cord-335975-m6lkrehi 586 1 Conclusion conclusion NN cord-335975-m6lkrehi 586 2 : : : cord-335975-m6lkrehi 587 1 Dialysis dialysis NN cord-335975-m6lkrehi 587 2 anticoagulation anticoagulation NN cord-335975-m6lkrehi 587 3 with with IN cord-335975-m6lkrehi 587 4 calcium calcium NN cord-335975-m6lkrehi 587 5 - - HYPH cord-335975-m6lkrehi 587 6 free free JJ cord-335975-m6lkrehi 587 7 citrate citrate NN cord-335975-m6lkrehi 587 8 containing contain VBG cord-335975-m6lkrehi 587 9 dialysate dialysate NNP cord-335975-m6lkrehi 587 10 is be VBZ cord-335975-m6lkrehi 587 11 an an DT cord-335975-m6lkrehi 587 12 easy easy JJ cord-335975-m6lkrehi 587 13 - - HYPH cord-335975-m6lkrehi 587 14 to to IN cord-335975-m6lkrehi 587 15 - - HYPH cord-335975-m6lkrehi 587 16 use use NN cord-335975-m6lkrehi 587 17 , , , cord-335975-m6lkrehi 587 18 efficient efficient JJ cord-335975-m6lkrehi 587 19 , , , cord-335975-m6lkrehi 587 20 and and CC cord-335975-m6lkrehi 587 21 inexpensive inexpensive JJ cord-335975-m6lkrehi 587 22 form form NN cord-335975-m6lkrehi 587 23 of of IN cord-335975-m6lkrehi 587 24 heparin heparin NN cord-335975-m6lkrehi 587 25 - - HYPH cord-335975-m6lkrehi 587 26 free free JJ cord-335975-m6lkrehi 587 27 regional regional JJ cord-335975-m6lkrehi 587 28 anticoagulation anticoagulation NN cord-335975-m6lkrehi 587 29 . . . cord-335975-m6lkrehi 588 1 Calcium calcium NN cord-335975-m6lkrehi 588 2 reinjection reinjection NN cord-335975-m6lkrehi 588 3 according accord VBG cord-335975-m6lkrehi 588 4 to to IN cord-335975-m6lkrehi 588 5 ionic ionic JJ cord-335975-m6lkrehi 588 6 dialysance dialysance NN cord-335975-m6lkrehi 588 7 allows allow VBZ cord-335975-m6lkrehi 588 8 prolonged prolonged JJ cord-335975-m6lkrehi 588 9 hemodialysis hemodialysis NN cord-335975-m6lkrehi 588 10 sessions session NNS cord-335975-m6lkrehi 588 11 in in IN cord-335975-m6lkrehi 588 12 critically critically RB cord-335975-m6lkrehi 588 13 ill ill JJ cord-335975-m6lkrehi 588 14 patients patient NNS cord-335975-m6lkrehi 588 15 without without IN cord-335975-m6lkrehi 588 16 the the DT cord-335975-m6lkrehi 588 17 need need NN cord-335975-m6lkrehi 588 18 to to TO cord-335975-m6lkrehi 588 19 systemically systemically RB cord-335975-m6lkrehi 588 20 monitor monitor VB cord-335975-m6lkrehi 588 21 ionized ionized JJ cord-335975-m6lkrehi 588 22 calcium calcium NN cord-335975-m6lkrehi 588 23 . . . cord-335975-m6lkrehi 589 1 Sessions session NNS cord-335975-m6lkrehi 589 2 can can MD cord-335975-m6lkrehi 589 3 be be VB cord-335975-m6lkrehi 589 4 safely safely RB cord-335975-m6lkrehi 589 5 extended extend VBN cord-335975-m6lkrehi 589 6 according accord VBG cord-335975-m6lkrehi 589 7 to to IN cord-335975-m6lkrehi 589 8 the the DT cord-335975-m6lkrehi 589 9 hemodynamic hemodynamic JJ cord-335975-m6lkrehi 589 10 tolerance tolerance NN cord-335975-m6lkrehi 589 11 to to TO cord-335975-m6lkrehi 589 12 ensure ensure VB cord-335975-m6lkrehi 589 13 an an DT cord-335975-m6lkrehi 589 14 adequate adequate JJ cord-335975-m6lkrehi 589 15 dose dose NN cord-335975-m6lkrehi 589 16 of of IN cord-335975-m6lkrehi 589 17 dialysis dialysis NN cord-335975-m6lkrehi 589 18 and and CC cord-335975-m6lkrehi 589 19 a a DT cord-335975-m6lkrehi 589 20 negative negative JJ cord-335975-m6lkrehi 589 21 water water NN cord-335975-m6lkrehi 589 22 balance balance NN cord-335975-m6lkrehi 589 23 , , , cord-335975-m6lkrehi 589 24 a a DT cord-335975-m6lkrehi 589 25 major major JJ cord-335975-m6lkrehi 589 26 point point NN cord-335975-m6lkrehi 589 27 in in IN cord-335975-m6lkrehi 589 28 patients patient NNS cord-335975-m6lkrehi 589 29 with with IN cord-335975-m6lkrehi 589 30 severe severe JJ cord-335975-m6lkrehi 589 31 AKI AKI NNP cord-335975-m6lkrehi 589 32 . . . cord-335975-m6lkrehi 590 1 Introduction introduction NN cord-335975-m6lkrehi 590 2 : : : cord-335975-m6lkrehi 591 1 Brain brain NN cord-335975-m6lkrehi 591 2 injury injury NN cord-335975-m6lkrehi 591 3 is be VBZ cord-335975-m6lkrehi 591 4 the the DT cord-335975-m6lkrehi 591 5 first first JJ cord-335975-m6lkrehi 591 6 cause cause NN cord-335975-m6lkrehi 591 7 of of IN cord-335975-m6lkrehi 591 8 death death NN cord-335975-m6lkrehi 591 9 after after IN cord-335975-m6lkrehi 591 10 cardiac cardiac JJ cord-335975-m6lkrehi 591 11 arrest arrest NN cord-335975-m6lkrehi 591 12 ( ( -LRB- cord-335975-m6lkrehi 591 13 CA CA NNP cord-335975-m6lkrehi 591 14 ) ) -RRB- cord-335975-m6lkrehi 591 15 and and CC cord-335975-m6lkrehi 592 1 multimodal multimodal NNP cord-335975-m6lkrehi 592 2 neuroprognostication neuroprognostication NNP cord-335975-m6lkrehi 592 3 is be VBZ cord-335975-m6lkrehi 592 4 a a DT cord-335975-m6lkrehi 592 5 cornerstone cornerstone NN cord-335975-m6lkrehi 592 6 of of IN cord-335975-m6lkrehi 592 7 postresuscitation postresuscitation NNP cord-335975-m6lkrehi 592 8 care care NN cord-335975-m6lkrehi 592 9 . . . cord-335975-m6lkrehi 593 1 Among among IN cord-335975-m6lkrehi 593 2 the the DT cord-335975-m6lkrehi 593 3 different different JJ cord-335975-m6lkrehi 593 4 usable usable JJ cord-335975-m6lkrehi 593 5 information information NN cord-335975-m6lkrehi 593 6 provide provide VBP cord-335975-m6lkrehi 593 7 by by IN cord-335975-m6lkrehi 593 8 electroencephalogram electroencephalogram FW cord-335975-m6lkrehi 593 9 ( ( -LRB- cord-335975-m6lkrehi 593 10 EEG EEG NNP cord-335975-m6lkrehi 593 11 ) ) -RRB- cord-335975-m6lkrehi 593 12 , , , cord-335975-m6lkrehi 593 13 the the DT cord-335975-m6lkrehi 593 14 aim aim NN cord-335975-m6lkrehi 593 15 of of IN cord-335975-m6lkrehi 593 16 this this DT cord-335975-m6lkrehi 593 17 study study NN cord-335975-m6lkrehi 593 18 was be VBD cord-335975-m6lkrehi 593 19 to to TO cord-335975-m6lkrehi 593 20 evaluate evaluate VB cord-335975-m6lkrehi 593 21 the the DT cord-335975-m6lkrehi 593 22 predictive predictive JJ cord-335975-m6lkrehi 593 23 value value NN cord-335975-m6lkrehi 593 24 of of IN cord-335975-m6lkrehi 593 25 EEG EEG NNP cord-335975-m6lkrehi 593 26 reactivity reactivity NN cord-335975-m6lkrehi 593 27 regarding regard VBG cord-335975-m6lkrehi 593 28 neurological neurological JJ cord-335975-m6lkrehi 593 29 outcome outcome NN cord-335975-m6lkrehi 593 30 at at IN cord-335975-m6lkrehi 593 31 discharge discharge NN cord-335975-m6lkrehi 593 32 . . . cord-335975-m6lkrehi 594 1 Patients patient NNS cord-335975-m6lkrehi 594 2 and and CC cord-335975-m6lkrehi 594 3 methods method NNS cord-335975-m6lkrehi 594 4 : : : cord-335975-m6lkrehi 594 5 Using use VBG cord-335975-m6lkrehi 594 6 our -PRON- PRP$ cord-335975-m6lkrehi 594 7 prospective prospective JJ cord-335975-m6lkrehi 594 8 registry registry NN cord-335975-m6lkrehi 594 9 of of IN cord-335975-m6lkrehi 594 10 successfully successfully RB cord-335975-m6lkrehi 594 11 resuscitated resuscitate VBN cord-335975-m6lkrehi 594 12 patients patient NNS cord-335975-m6lkrehi 594 13 admitted admit VBN cord-335975-m6lkrehi 594 14 to to IN cord-335975-m6lkrehi 594 15 a a DT cord-335975-m6lkrehi 594 16 cardiac cardiac JJ cord-335975-m6lkrehi 594 17 arrest arrest NN cord-335975-m6lkrehi 594 18 center center NN cord-335975-m6lkrehi 594 19 between between IN cord-335975-m6lkrehi 594 20 January January NNP cord-335975-m6lkrehi 594 21 2007 2007 CD cord-335975-m6lkrehi 594 22 and and CC cord-335975-m6lkrehi 594 23 2016 2016 CD cord-335975-m6lkrehi 595 1 , , , cord-335975-m6lkrehi 595 2 we -PRON- PRP cord-335975-m6lkrehi 595 3 studied study VBD cord-335975-m6lkrehi 595 4 all all DT cord-335975-m6lkrehi 595 5 consecutive consecutive JJ cord-335975-m6lkrehi 595 6 comatose comatose JJ cord-335975-m6lkrehi 595 7 patients patient NNS cord-335975-m6lkrehi 595 8 still still RB cord-335975-m6lkrehi 595 9 alive alive JJ cord-335975-m6lkrehi 595 10 at at IN cord-335975-m6lkrehi 595 11 48 48 CD cord-335975-m6lkrehi 595 12 h h NN cord-335975-m6lkrehi 595 13 and and CC cord-335975-m6lkrehi 595 14 in in IN cord-335975-m6lkrehi 595 15 whom whom WP cord-335975-m6lkrehi 595 16 at at IN cord-335975-m6lkrehi 595 17 least least RBS cord-335975-m6lkrehi 595 18 one one CD cord-335975-m6lkrehi 595 19 EEG EEG NNP cord-335975-m6lkrehi 595 20 was be VBD cord-335975-m6lkrehi 595 21 performed perform VBN cord-335975-m6lkrehi 595 22 during during IN cord-335975-m6lkrehi 595 23 coma coma NN cord-335975-m6lkrehi 595 24 . . . cord-335975-m6lkrehi 596 1 In in IN cord-335975-m6lkrehi 596 2 addition addition NN cord-335975-m6lkrehi 596 3 to to IN cord-335975-m6lkrehi 596 4 usual usual JJ cord-335975-m6lkrehi 596 5 clinical clinical JJ cord-335975-m6lkrehi 596 6 findings finding NNS cord-335975-m6lkrehi 596 7 , , , cord-335975-m6lkrehi 596 8 we -PRON- PRP cord-335975-m6lkrehi 596 9 collected collect VBD cord-335975-m6lkrehi 596 10 EEG EEG NNP cord-335975-m6lkrehi 596 11 ( ( -LRB- cord-335975-m6lkrehi 596 12 patterns pattern NNS cord-335975-m6lkrehi 596 13 and and CC cord-335975-m6lkrehi 596 14 reactivity reactivity NN cord-335975-m6lkrehi 596 15 , , , cord-335975-m6lkrehi 596 16 status status NN cord-335975-m6lkrehi 596 17 epilepticus epilepticus NN cord-335975-m6lkrehi 596 18 ) ) -RRB- cord-335975-m6lkrehi 596 19 and and CC cord-335975-m6lkrehi 596 20 somatosensory somatosensory NN cord-335975-m6lkrehi 596 21 evoked evoke VBN cord-335975-m6lkrehi 596 22 potentials potential NNS cord-335975-m6lkrehi 596 23 characteristics characteristic NNS cord-335975-m6lkrehi 596 24 . . . cord-335975-m6lkrehi 597 1 The the DT cord-335975-m6lkrehi 597 2 EEG EEG NNP cord-335975-m6lkrehi 597 3 reactivity reactivity NN cord-335975-m6lkrehi 597 4 was be VBD cord-335975-m6lkrehi 597 5 evaluated evaluate VBN cord-335975-m6lkrehi 597 6 by by IN cord-335975-m6lkrehi 597 7 a a DT cord-335975-m6lkrehi 597 8 blinded blinded JJ cord-335975-m6lkrehi 597 9 neurophysiologist neurophysiologist NN cord-335975-m6lkrehi 597 10 and and CC cord-335975-m6lkrehi 597 11 was be VBD cord-335975-m6lkrehi 597 12 defined define VBN cord-335975-m6lkrehi 597 13 as as IN cord-335975-m6lkrehi 597 14 a a DT cord-335975-m6lkrehi 597 15 reproducible reproducible JJ cord-335975-m6lkrehi 597 16 change change NN cord-335975-m6lkrehi 597 17 of of IN cord-335975-m6lkrehi 597 18 the the DT cord-335975-m6lkrehi 597 19 tracing tracing NN cord-335975-m6lkrehi 597 20 ( ( -LRB- cord-335975-m6lkrehi 597 21 in in IN cord-335975-m6lkrehi 597 22 amplitude amplitude NN cord-335975-m6lkrehi 597 23 or or CC cord-335975-m6lkrehi 597 24 frequency frequency NN cord-335975-m6lkrehi 597 25 ) ) -RRB- cord-335975-m6lkrehi 597 26 provoked provoke VBN cord-335975-m6lkrehi 597 27 by by IN cord-335975-m6lkrehi 597 28 an an DT cord-335975-m6lkrehi 597 29 auditory auditory NN cord-335975-m6lkrehi 597 30 and and CC cord-335975-m6lkrehi 597 31 a a DT cord-335975-m6lkrehi 597 32 nociceptive nociceptive JJ cord-335975-m6lkrehi 597 33 standardized standardize VBN cord-335975-m6lkrehi 597 34 stimulation stimulation NN cord-335975-m6lkrehi 597 35 . . . cord-335975-m6lkrehi 598 1 We -PRON- PRP cord-335975-m6lkrehi 598 2 evaluated evaluate VBD cord-335975-m6lkrehi 598 3 the the DT cord-335975-m6lkrehi 598 4 predictive predictive JJ cord-335975-m6lkrehi 598 5 values value NNS cord-335975-m6lkrehi 598 6 of of IN cord-335975-m6lkrehi 598 7 persistent persistent JJ cord-335975-m6lkrehi 598 8 lack lack NN cord-335975-m6lkrehi 598 9 EEG EEG NNP cord-335975-m6lkrehi 598 10 reactivity reactivity NN cord-335975-m6lkrehi 598 11 and and CC cord-335975-m6lkrehi 598 12 other other JJ cord-335975-m6lkrehi 598 13 indicators indicator NNS cord-335975-m6lkrehi 598 14 regarding regard VBG cord-335975-m6lkrehi 598 15 their -PRON- PRP$ cord-335975-m6lkrehi 598 16 respective respective JJ cord-335975-m6lkrehi 598 17 ability ability NN cord-335975-m6lkrehi 598 18 to to TO cord-335975-m6lkrehi 598 19 predict predict VB cord-335975-m6lkrehi 598 20 a a DT cord-335975-m6lkrehi 598 21 favorable favorable JJ cord-335975-m6lkrehi 598 22 or or CC cord-335975-m6lkrehi 598 23 unfavorable unfavorable JJ cord-335975-m6lkrehi 598 24 outcome outcome NN cord-335975-m6lkrehi 598 25 . . . cord-335975-m6lkrehi 599 1 Recovery recovery NN cord-335975-m6lkrehi 599 2 of of IN cord-335975-m6lkrehi 599 3 a a DT cord-335975-m6lkrehi 599 4 level level NN cord-335975-m6lkrehi 599 5 1 1 CD cord-335975-m6lkrehi 599 6 or or CC cord-335975-m6lkrehi 599 7 2 2 CD cord-335975-m6lkrehi 599 8 on on IN cord-335975-m6lkrehi 599 9 the the DT cord-335975-m6lkrehi 599 10 Cerebral Cerebral NNP cord-335975-m6lkrehi 599 11 Performance Performance NNP cord-335975-m6lkrehi 599 12 Category Category NNP cord-335975-m6lkrehi 599 13 ( ( -LRB- cord-335975-m6lkrehi 599 14 CPC CPC NNP cord-335975-m6lkrehi 599 15 ) ) -RRB- cord-335975-m6lkrehi 599 16 scale scale NN cord-335975-m6lkrehi 599 17 at at IN cord-335975-m6lkrehi 599 18 discharge discharge NN cord-335975-m6lkrehi 599 19 was be VBD cord-335975-m6lkrehi 599 20 considered consider VBN cord-335975-m6lkrehi 599 21 as as IN cord-335975-m6lkrehi 599 22 a a DT cord-335975-m6lkrehi 599 23 favorable favorable JJ cord-335975-m6lkrehi 599 24 outcome outcome NN cord-335975-m6lkrehi 599 25 , , , cord-335975-m6lkrehi 599 26 as as IN cord-335975-m6lkrehi 599 27 opposed oppose VBN cord-335975-m6lkrehi 599 28 to to IN cord-335975-m6lkrehi 599 29 recovery recovery NN cord-335975-m6lkrehi 599 30 of of IN cord-335975-m6lkrehi 599 31 a a DT cord-335975-m6lkrehi 599 32 CPC CPC NNP cord-335975-m6lkrehi 599 33 level level NN cord-335975-m6lkrehi 599 34 3 3 CD cord-335975-m6lkrehi 599 35 - - SYM cord-335975-m6lkrehi 599 36 5 5 CD cord-335975-m6lkrehi 599 37 ( ( -LRB- cord-335975-m6lkrehi 599 38 unfavorable unfavorable JJ cord-335975-m6lkrehi 599 39 outcome outcome NN cord-335975-m6lkrehi 599 40 ) ) -RRB- cord-335975-m6lkrehi 599 41 . . . cord-335975-m6lkrehi 600 1 We -PRON- PRP cord-335975-m6lkrehi 600 2 included include VBD cord-335975-m6lkrehi 600 3 428 428 CD cord-335975-m6lkrehi 600 4 patients patient NNS cord-335975-m6lkrehi 600 5 who who WP cord-335975-m6lkrehi 600 6 were be VBD cord-335975-m6lkrehi 600 7 mostly mostly RB cord-335975-m6lkrehi 600 8 male male JJ cord-335975-m6lkrehi 600 9 ( ( -LRB- cord-335975-m6lkrehi 600 10 71 71 CD cord-335975-m6lkrehi 600 11 % % NN cord-335975-m6lkrehi 600 12 ) ) -RRB- cord-335975-m6lkrehi 600 13 , , , cord-335975-m6lkrehi 600 14 with with IN cord-335975-m6lkrehi 600 15 median median JJ cord-335975-m6lkrehi 600 16 age age NN cord-335975-m6lkrehi 600 17 of of IN cord-335975-m6lkrehi 600 18 63 63 CD cord-335975-m6lkrehi 600 19 years year NNS cord-335975-m6lkrehi 600 20 . . . cord-335975-m6lkrehi 601 1 CA CA NNP cord-335975-m6lkrehi 601 2 occurred occur VBD cord-335975-m6lkrehi 601 3 in in IN cord-335975-m6lkrehi 601 4 a a DT cord-335975-m6lkrehi 601 5 public public JJ cord-335975-m6lkrehi 601 6 place place NN cord-335975-m6lkrehi 601 7 in in IN cord-335975-m6lkrehi 601 8 32 32 CD cord-335975-m6lkrehi 601 9 % % NN cord-335975-m6lkrehi 601 10 of of IN cord-335975-m6lkrehi 601 11 cases case NNS cord-335975-m6lkrehi 601 12 , , , cord-335975-m6lkrehi 601 13 and and CC cord-335975-m6lkrehi 601 14 it -PRON- PRP cord-335975-m6lkrehi 601 15 was be VBD cord-335975-m6lkrehi 601 16 witnessed witness VBN cord-335975-m6lkrehi 601 17 in in IN cord-335975-m6lkrehi 601 18 89 89 CD cord-335975-m6lkrehi 601 19 % % NN cord-335975-m6lkrehi 601 20 of of IN cord-335975-m6lkrehi 601 21 cases case NNS cord-335975-m6lkrehi 601 22 . . . cord-335975-m6lkrehi 602 1 Bystander Bystander NNP cord-335975-m6lkrehi 602 2 CPR CPR NNP cord-335975-m6lkrehi 602 3 was be VBD cord-335975-m6lkrehi 602 4 initiated initiate VBN cord-335975-m6lkrehi 602 5 in in IN cord-335975-m6lkrehi 602 6 61 61 CD cord-335975-m6lkrehi 602 7 % % NN cord-335975-m6lkrehi 602 8 patients patient NNS cord-335975-m6lkrehi 602 9 and and CC cord-335975-m6lkrehi 602 10 the the DT cord-335975-m6lkrehi 602 11 initial initial JJ cord-335975-m6lkrehi 602 12 cardiac cardiac JJ cord-335975-m6lkrehi 602 13 rhythm rhythm NN cord-335975-m6lkrehi 602 14 was be VBD cord-335975-m6lkrehi 602 15 shockable shockable JJ cord-335975-m6lkrehi 602 16 in in IN cord-335975-m6lkrehi 602 17 49 49 CD cord-335975-m6lkrehi 602 18 % % NN cord-335975-m6lkrehi 602 19 patients patient NNS cord-335975-m6lkrehi 602 20 . . . cord-335975-m6lkrehi 603 1 Median median JJ cord-335975-m6lkrehi 603 2 time time NN cord-335975-m6lkrehi 603 3 to to IN cord-335975-m6lkrehi 603 4 EEG EEG NNP cord-335975-m6lkrehi 603 5 was be VBD cord-335975-m6lkrehi 603 6 3 3 CD cord-335975-m6lkrehi 603 7 days day NNS cord-335975-m6lkrehi 603 8 ( ( -LRB- cord-335975-m6lkrehi 603 9 1 1 CD cord-335975-m6lkrehi 603 10 - - SYM cord-335975-m6lkrehi 603 11 4 4 CD cord-335975-m6lkrehi 603 12 ) ) -RRB- cord-335975-m6lkrehi 603 13 and and CC cord-335975-m6lkrehi 603 14 43 43 CD cord-335975-m6lkrehi 603 15 % % NN cord-335975-m6lkrehi 603 16 of of IN cord-335975-m6lkrehi 603 17 patients patient NNS cord-335975-m6lkrehi 603 18 were be VBD cord-335975-m6lkrehi 603 19 still still RB cord-335975-m6lkrehi 603 20 sedated sedate VBN cord-335975-m6lkrehi 603 21 during during IN cord-335975-m6lkrehi 603 22 the the DT cord-335975-m6lkrehi 603 23 examination examination NN cord-335975-m6lkrehi 603 24 . . . cord-335975-m6lkrehi 604 1 A a DT cord-335975-m6lkrehi 604 2 favorable favorable JJ cord-335975-m6lkrehi 604 3 neurologic neurologic JJ cord-335975-m6lkrehi 604 4 outcome outcome NN cord-335975-m6lkrehi 604 5 was be VBD cord-335975-m6lkrehi 604 6 observed observe VBN cord-335975-m6lkrehi 604 7 in in IN cord-335975-m6lkrehi 604 8 85 85 CD cord-335975-m6lkrehi 604 9 patients patient NNS cord-335975-m6lkrehi 604 10 ( ( -LRB- cord-335975-m6lkrehi 604 11 20 20 CD cord-335975-m6lkrehi 604 12 % % NN cord-335975-m6lkrehi 604 13 ) ) -RRB- cord-335975-m6lkrehi 604 14 . . . cord-335975-m6lkrehi 605 1 An an DT cord-335975-m6lkrehi 605 2 EEG EEG NNP cord-335975-m6lkrehi 605 3 reactivity reactivity NN cord-335975-m6lkrehi 605 4 was be VBD cord-335975-m6lkrehi 605 5 present present JJ cord-335975-m6lkrehi 605 6 in in IN cord-335975-m6lkrehi 605 7 78 78 CD cord-335975-m6lkrehi 605 8 85 85 CD cord-335975-m6lkrehi 605 9 patients patient NNS cord-335975-m6lkrehi 605 10 ( ( -LRB- cord-335975-m6lkrehi 605 11 92 92 CD cord-335975-m6lkrehi 605 12 % % NN cord-335975-m6lkrehi 605 13 ) ) -RRB- cord-335975-m6lkrehi 605 14 with with IN cord-335975-m6lkrehi 605 15 favorable favorable JJ cord-335975-m6lkrehi 605 16 outcome outcome NN cord-335975-m6lkrehi 605 17 and and CC cord-335975-m6lkrehi 605 18 in in IN cord-335975-m6lkrehi 605 19 117 117 CD cord-335975-m6lkrehi 605 20 343 343 CD cord-335975-m6lkrehi 605 21 patients patient NNS cord-335975-m6lkrehi 605 22 ( ( -LRB- cord-335975-m6lkrehi 605 23 34 34 CD cord-335975-m6lkrehi 605 24 % % NN cord-335975-m6lkrehi 605 25 ) ) -RRB- cord-335975-m6lkrehi 605 26 with with IN cord-335975-m6lkrehi 605 27 unfavorable unfavorable JJ cord-335975-m6lkrehi 605 28 outcome outcome NN cord-335975-m6lkrehi 605 29 . . . cord-335975-m6lkrehi 606 1 The the DT cord-335975-m6lkrehi 606 2 positive positive JJ cord-335975-m6lkrehi 606 3 predictive predictive JJ cord-335975-m6lkrehi 606 4 value value NN cord-335975-m6lkrehi 606 5 ( ( -LRB- cord-335975-m6lkrehi 606 6 PPV PPV NNP cord-335975-m6lkrehi 606 7 ) ) -RRB- cord-335975-m6lkrehi 606 8 of of IN cord-335975-m6lkrehi 606 9 a a DT cord-335975-m6lkrehi 606 10 persistent persistent JJ cord-335975-m6lkrehi 606 11 EEG EEG NNP cord-335975-m6lkrehi 606 12 reactivity reactivity NN cord-335975-m6lkrehi 606 13 for for IN cord-335975-m6lkrehi 606 14 prediction prediction NN cord-335975-m6lkrehi 606 15 of of IN cord-335975-m6lkrehi 606 16 favorable favorable JJ cord-335975-m6lkrehi 606 17 outcome outcome NN cord-335975-m6lkrehi 606 18 was be VBD cord-335975-m6lkrehi 606 19 40 40 CD cord-335975-m6lkrehi 606 20 % % NN cord-335975-m6lkrehi 606 21 . . . cord-335975-m6lkrehi 607 1 By by IN cord-335975-m6lkrehi 607 2 contrast contrast NN cord-335975-m6lkrehi 607 3 , , , cord-335975-m6lkrehi 607 4 the the DT cord-335975-m6lkrehi 607 5 PPV PPV NNP cord-335975-m6lkrehi 607 6 of of IN cord-335975-m6lkrehi 607 7 lost lose VBN cord-335975-m6lkrehi 607 8 EEG EEG NNP cord-335975-m6lkrehi 607 9 reactivity reactivity NN cord-335975-m6lkrehi 607 10 for for IN cord-335975-m6lkrehi 607 11 prediction prediction NN cord-335975-m6lkrehi 607 12 of of IN cord-335975-m6lkrehi 607 13 unfavorable unfavorable JJ cord-335975-m6lkrehi 607 14 outcome outcome NN cord-335975-m6lkrehi 607 15 was be VBD cord-335975-m6lkrehi 607 16 97 97 CD cord-335975-m6lkrehi 607 17 % % NN cord-335975-m6lkrehi 607 18 ( ( -LRB- cord-335975-m6lkrehi 607 19 IC IC NNP cord-335975-m6lkrehi 607 20 95 95 CD cord-335975-m6lkrehi 607 21 % % NN cord-335975-m6lkrehi 607 22 94 94 CD cord-335975-m6lkrehi 607 23 - - SYM cord-335975-m6lkrehi 607 24 99 99 CD cord-335975-m6lkrehi 607 25 ) ) -RRB- cord-335975-m6lkrehi 607 26 with with IN cord-335975-m6lkrehi 607 27 a a DT cord-335975-m6lkrehi 607 28 false false JJ cord-335975-m6lkrehi 607 29 positive positive JJ cord-335975-m6lkrehi 607 30 rate rate NN cord-335975-m6lkrehi 607 31 ( ( -LRB- cord-335975-m6lkrehi 607 32 FRP FRP NNP cord-335975-m6lkrehi 607 33 ) ) -RRB- cord-335975-m6lkrehi 607 34 of of IN cord-335975-m6lkrehi 607 35 2.8 2.8 CD cord-335975-m6lkrehi 607 36 % % NN cord-335975-m6lkrehi 607 37 ( ( -LRB- cord-335975-m6lkrehi 607 38 1.2 1.2 CD cord-335975-m6lkrehi 607 39 - - SYM cord-335975-m6lkrehi 607 40 4.4 4.4 CD cord-335975-m6lkrehi 607 41 ) ) -RRB- cord-335975-m6lkrehi 607 42 . . . cord-335975-m6lkrehi 608 1 EEG EEG NNP cord-335975-m6lkrehi 608 2 electroencephalogram electroencephalogram NN cord-335975-m6lkrehi 608 3 , , , cord-335975-m6lkrehi 608 4 SSEP SSEP NNP cord-335975-m6lkrehi 608 5 short short JJ cord-335975-m6lkrehi 608 6 - - HYPH cord-335975-m6lkrehi 608 7 latency latency NN cord-335975-m6lkrehi 608 8 somatosensory somatosensory NN cord-335975-m6lkrehi 608 9 evoked evoke VBN cord-335975-m6lkrehi 608 10 potentials potential NNS cord-335975-m6lkrehi 608 11 , , , cord-335975-m6lkrehi 608 12 PPV PPV NNP cord-335975-m6lkrehi 608 13 positive positive JJ cord-335975-m6lkrehi 608 14 predictive predictive JJ cord-335975-m6lkrehi 608 15 value value NN cord-335975-m6lkrehi 608 16 , , , cord-335975-m6lkrehi 608 17 NPV NPV NNP cord-335975-m6lkrehi 608 18 negative negative JJ cord-335975-m6lkrehi 608 19 predictive predictive JJ cord-335975-m6lkrehi 608 20 value value NN cord-335975-m6lkrehi 608 21 , , , cord-335975-m6lkrehi 608 22 FPR fpr VB cord-335975-m6lkrehi 608 23 false false JJ cord-335975-m6lkrehi 608 24 positive positive JJ cord-335975-m6lkrehi 608 25 rate rate NN cord-335975-m6lkrehi 608 26 In in IN cord-335975-m6lkrehi 608 27 this this DT cord-335975-m6lkrehi 608 28 population population NN cord-335975-m6lkrehi 608 29 of of IN cord-335975-m6lkrehi 608 30 post post JJ cord-335975-m6lkrehi 608 31 - - JJ cord-335975-m6lkrehi 608 32 cardiac cardiac JJ cord-335975-m6lkrehi 608 33 arrest arrest NN cord-335975-m6lkrehi 608 34 patients patient NNS cord-335975-m6lkrehi 608 35 , , , cord-335975-m6lkrehi 608 36 the the DT cord-335975-m6lkrehi 608 37 presence presence NN cord-335975-m6lkrehi 608 38 of of IN cord-335975-m6lkrehi 608 39 EEG EEG NNP cord-335975-m6lkrehi 608 40 reactivity reactivity NN cord-335975-m6lkrehi 608 41 was be VBD cord-335975-m6lkrehi 608 42 poorly poorly RB cord-335975-m6lkrehi 608 43 predictive predictive JJ cord-335975-m6lkrehi 608 44 of of IN cord-335975-m6lkrehi 608 45 a a DT cord-335975-m6lkrehi 608 46 favorable favorable JJ cord-335975-m6lkrehi 608 47 neurologic neurologic JJ cord-335975-m6lkrehi 608 48 outcome outcome NN cord-335975-m6lkrehi 608 49 . . . cord-335975-m6lkrehi 609 1 The the DT cord-335975-m6lkrehi 609 2 absence absence NN cord-335975-m6lkrehi 609 3 of of IN cord-335975-m6lkrehi 609 4 reactivity reactivity NN cord-335975-m6lkrehi 609 5 was be VBD cord-335975-m6lkrehi 609 6 highly highly RB cord-335975-m6lkrehi 609 7 predictive predictive JJ cord-335975-m6lkrehi 609 8 of of IN cord-335975-m6lkrehi 609 9 unfavorable unfavorable JJ cord-335975-m6lkrehi 609 10 outcome outcome NN cord-335975-m6lkrehi 609 11 . . . cord-335975-m6lkrehi 610 1 In in IN cord-335975-m6lkrehi 610 2 combination combination NN cord-335975-m6lkrehi 610 3 with with IN cord-335975-m6lkrehi 610 4 other other JJ cord-335975-m6lkrehi 610 5 indicators indicator NNS cord-335975-m6lkrehi 610 6 , , , cord-335975-m6lkrehi 610 7 searching search VBG cord-335975-m6lkrehi 610 8 for for IN cord-335975-m6lkrehi 610 9 EEG EEG NNP cord-335975-m6lkrehi 610 10 reactivity reactivity NN cord-335975-m6lkrehi 610 11 may may MD cord-335975-m6lkrehi 610 12 have have VB cord-335975-m6lkrehi 610 13 important important JJ cord-335975-m6lkrehi 610 14 implications implication NNS cord-335975-m6lkrehi 610 15 in in IN cord-335975-m6lkrehi 610 16 the the DT cord-335975-m6lkrehi 610 17 neuroprognostication neuroprognostication NN cord-335975-m6lkrehi 610 18 process process NN cord-335975-m6lkrehi 610 19 . . . cord-335975-m6lkrehi 611 1 Conclusion conclusion NN cord-335975-m6lkrehi 611 2 : : : cord-335975-m6lkrehi 612 1 This this DT cord-335975-m6lkrehi 612 2 subgroup subgroup NN cord-335975-m6lkrehi 612 3 analyses analyse VBZ cord-335975-m6lkrehi 612 4 of of IN cord-335975-m6lkrehi 612 5 a a DT cord-335975-m6lkrehi 612 6 randomized randomized JJ cord-335975-m6lkrehi 612 7 controlled control VBN cord-335975-m6lkrehi 612 8 trial trial NN cord-335975-m6lkrehi 612 9 , , , cord-335975-m6lkrehi 612 10 found find VBD cord-335975-m6lkrehi 612 11 no no DT cord-335975-m6lkrehi 612 12 survival survival NN cord-335975-m6lkrehi 612 13 benefit benefit NN cord-335975-m6lkrehi 612 14 when when WRB cord-335975-m6lkrehi 612 15 comparing compare VBG cord-335975-m6lkrehi 612 16 crystalloids crystalloid NNS cord-335975-m6lkrehi 612 17 to to IN cord-335975-m6lkrehi 612 18 colloids colloid NNS cord-335975-m6lkrehi 612 19 in in IN cord-335975-m6lkrehi 612 20 critically critically RB cord-335975-m6lkrehi 612 21 ill ill JJ cord-335975-m6lkrehi 612 22 surgical surgical JJ cord-335975-m6lkrehi 612 23 patients patient NNS cord-335975-m6lkrehi 612 24 . . . cord-335975-m6lkrehi 613 1 Introduction introduction NN cord-335975-m6lkrehi 613 2 : : : cord-335975-m6lkrehi 614 1 Goal goal NN cord-335975-m6lkrehi 614 2 of of IN cord-335975-m6lkrehi 614 3 a a DT cord-335975-m6lkrehi 614 4 fluid fluid JJ cord-335975-m6lkrehi 614 5 challenge challenge NN cord-335975-m6lkrehi 614 6 ( ( -LRB- cord-335975-m6lkrehi 614 7 FC FC NNP cord-335975-m6lkrehi 614 8 ) ) -RRB- cord-335975-m6lkrehi 614 9 is be VBZ cord-335975-m6lkrehi 614 10 in in IN cord-335975-m6lkrehi 614 11 fine fine NN cord-335975-m6lkrehi 614 12 to to TO cord-335975-m6lkrehi 614 13 increase increase VB cord-335975-m6lkrehi 614 14 the the DT cord-335975-m6lkrehi 614 15 stroke stroke NN cord-335975-m6lkrehi 614 16 volume volume NN cord-335975-m6lkrehi 614 17 ( ( -LRB- cord-335975-m6lkrehi 614 18 SV SV NNP cord-335975-m6lkrehi 614 19 ) ) -RRB- cord-335975-m6lkrehi 614 20 or or CC cord-335975-m6lkrehi 614 21 the the DT cord-335975-m6lkrehi 614 22 cardiac cardiac JJ cord-335975-m6lkrehi 614 23 index index NN cord-335975-m6lkrehi 614 24 ( ( -LRB- cord-335975-m6lkrehi 614 25 CI CI NNP cord-335975-m6lkrehi 614 26 ) ) -RRB- cord-335975-m6lkrehi 614 27 when when WRB cord-335975-m6lkrehi 614 28 an an DT cord-335975-m6lkrehi 614 29 episode episode NN cord-335975-m6lkrehi 614 30 of of IN cord-335975-m6lkrehi 614 31 hypovolemia hypovolemia NN cord-335975-m6lkrehi 614 32 or or CC cord-335975-m6lkrehi 614 33 a a DT cord-335975-m6lkrehi 614 34 preload preload NN cord-335975-m6lkrehi 614 35 dependence dependence NN cord-335975-m6lkrehi 614 36 status status NN cord-335975-m6lkrehi 614 37 are be VBP cord-335975-m6lkrehi 614 38 suspected suspect VBN cord-335975-m6lkrehi 614 39 . . . cord-335975-m6lkrehi 615 1 FC FC NNP cord-335975-m6lkrehi 615 2 is be VBZ cord-335975-m6lkrehi 615 3 one one CD cord-335975-m6lkrehi 615 4 of of IN cord-335975-m6lkrehi 615 5 the the DT cord-335975-m6lkrehi 615 6 most most RBS cord-335975-m6lkrehi 615 7 common common JJ cord-335975-m6lkrehi 615 8 practices practice NNS cord-335975-m6lkrehi 615 9 in in IN cord-335975-m6lkrehi 615 10 ICUs ICUs NNP cord-335975-m6lkrehi 615 11 , , , cord-335975-m6lkrehi 615 12 however however RB cord-335975-m6lkrehi 615 13 , , , cord-335975-m6lkrehi 615 14 the the DT cord-335975-m6lkrehi 615 15 way way NN cord-335975-m6lkrehi 615 16 to to TO cord-335975-m6lkrehi 615 17 assess assess VB cord-335975-m6lkrehi 615 18 the the DT cord-335975-m6lkrehi 615 19 response response NN cord-335975-m6lkrehi 615 20 to to IN cord-335975-m6lkrehi 615 21 FC FC NNP cord-335975-m6lkrehi 615 22 is be VBZ cord-335975-m6lkrehi 615 23 not not RB cord-335975-m6lkrehi 615 24 standardized standardize VBN cord-335975-m6lkrehi 615 25 . . . cord-335975-m6lkrehi 616 1 The the DT cord-335975-m6lkrehi 616 2 present present JJ cord-335975-m6lkrehi 616 3 study study NN cord-335975-m6lkrehi 616 4 aimed aim VBN cord-335975-m6lkrehi 616 5 to to TO cord-335975-m6lkrehi 616 6 evaluate evaluate VB cord-335975-m6lkrehi 616 7 whether whether IN cord-335975-m6lkrehi 616 8 the the DT cord-335975-m6lkrehi 616 9 trans trans JJ cord-335975-m6lkrehi 616 10 - - JJ cord-335975-m6lkrehi 616 11 thoracic thoracic JJ cord-335975-m6lkrehi 616 12 echocardiographic echocardiographic NNP cord-335975-m6lkrehi 616 13 ( ( -LRB- cord-335975-m6lkrehi 616 14 TTE TTE NNP cord-335975-m6lkrehi 616 15 ) ) -RRB- cord-335975-m6lkrehi 616 16 assessment assessment NN cord-335975-m6lkrehi 616 17 of of IN cord-335975-m6lkrehi 616 18 the the DT cord-335975-m6lkrehi 616 19 response response NN cord-335975-m6lkrehi 616 20 to to IN cord-335975-m6lkrehi 616 21 FC FC NNP cord-335975-m6lkrehi 616 22 immediately immediately RB cord-335975-m6lkrehi 616 23 at at IN cord-335975-m6lkrehi 616 24 the the DT cord-335975-m6lkrehi 616 25 end end NN cord-335975-m6lkrehi 616 26 of of IN cord-335975-m6lkrehi 616 27 the the DT cord-335975-m6lkrehi 616 28 infusion infusion NN cord-335975-m6lkrehi 616 29 or or CC cord-335975-m6lkrehi 616 30 delayed delay VBD cord-335975-m6lkrehi 616 31 20 20 CD cord-335975-m6lkrehi 616 32 min min NN cord-335975-m6lkrehi 616 33 later later RB cord-335975-m6lkrehi 616 34 could could MD cord-335975-m6lkrehi 616 35 affect affect VB cord-335975-m6lkrehi 616 36 the the DT cord-335975-m6lkrehi 616 37 results result NNS cord-335975-m6lkrehi 616 38 of of IN cord-335975-m6lkrehi 616 39 the the DT cord-335975-m6lkrehi 616 40 FC FC NNP cord-335975-m6lkrehi 616 41 . . . cord-335975-m6lkrehi 617 1 Patients patient NNS cord-335975-m6lkrehi 617 2 and and CC cord-335975-m6lkrehi 617 3 methods method NNS cord-335975-m6lkrehi 617 4 : : : cord-335975-m6lkrehi 617 5 Prospective prospective JJ cord-335975-m6lkrehi 617 6 , , , cord-335975-m6lkrehi 617 7 observational observational JJ cord-335975-m6lkrehi 617 8 , , , cord-335975-m6lkrehi 617 9 multicentre multicentre NNP cord-335975-m6lkrehi 617 10 study study VBP cord-335975-m6lkrehi 617 11 including include VBG cord-335975-m6lkrehi 617 12 all all DT cord-335975-m6lkrehi 617 13 ICU ICU NNP cord-335975-m6lkrehi 617 14 patients patient NNS cord-335975-m6lkrehi 617 15 in in IN cord-335975-m6lkrehi 617 16 septic septic JJ cord-335975-m6lkrehi 617 17 shock shock NN cord-335975-m6lkrehi 617 18 requiring require VBG cord-335975-m6lkrehi 617 19 a a DT cord-335975-m6lkrehi 617 20 FC fc NN cord-335975-m6lkrehi 617 21 . . . cord-335975-m6lkrehi 618 1 Were be VBD cord-335975-m6lkrehi 618 2 excluded exclude VBN cord-335975-m6lkrehi 618 3 patients patient NNS cord-335975-m6lkrehi 618 4 with with IN cord-335975-m6lkrehi 618 5 - - HYPH cord-335975-m6lkrehi 618 6 arrhythmias arrhythmias RB cord-335975-m6lkrehi 618 7 , , , cord-335975-m6lkrehi 618 8 poor poor JJ cord-335975-m6lkrehi 618 9 echogenicity echogenicity NN cord-335975-m6lkrehi 618 10 and and CC cord-335975-m6lkrehi 618 11 severe severe JJ cord-335975-m6lkrehi 618 12 mitral mitral JJ cord-335975-m6lkrehi 618 13 or or CC cord-335975-m6lkrehi 618 14 aortic aortic JJ cord-335975-m6lkrehi 618 15 regurgitation regurgitation NN cord-335975-m6lkrehi 618 16 . . . cord-335975-m6lkrehi 619 1 FC FC NNP cord-335975-m6lkrehi 619 2 was be VBD cord-335975-m6lkrehi 619 3 performed perform VBN cord-335975-m6lkrehi 619 4 administering administer VBG cord-335975-m6lkrehi 619 5 500 500 CD cord-335975-m6lkrehi 619 6 mL ml NN cord-335975-m6lkrehi 619 7 of of IN cord-335975-m6lkrehi 619 8 crystalloids crystalloid NNS cord-335975-m6lkrehi 619 9 over over IN cord-335975-m6lkrehi 619 10 10 10 CD cord-335975-m6lkrehi 619 11 min min NN cord-335975-m6lkrehi 619 12 . . . cord-335975-m6lkrehi 620 1 Fluid fluid JJ cord-335975-m6lkrehi 620 2 responsiveness responsiveness NN cord-335975-m6lkrehi 620 3 was be VBD cord-335975-m6lkrehi 620 4 defined define VBN cord-335975-m6lkrehi 620 5 as as IN cord-335975-m6lkrehi 620 6 a a DT cord-335975-m6lkrehi 620 7 > > XX cord-335975-m6lkrehi 620 8 15 15 CD cord-335975-m6lkrehi 620 9 % % NN cord-335975-m6lkrehi 620 10 increase increase NN cord-335975-m6lkrehi 620 11 in in IN cord-335975-m6lkrehi 620 12 stroke stroke NN cord-335975-m6lkrehi 620 13 volume volume NN cord-335975-m6lkrehi 620 14 ( ( -LRB- cord-335975-m6lkrehi 620 15 SV SV NNP cord-335975-m6lkrehi 620 16 ) ) -RRB- cord-335975-m6lkrehi 620 17 . . . cord-335975-m6lkrehi 621 1 The the DT cord-335975-m6lkrehi 621 2 following follow VBG cord-335975-m6lkrehi 621 3 echocardiographic echocardiographic JJ cord-335975-m6lkrehi 621 4 parameters parameter NNS cord-335975-m6lkrehi 621 5 were be VBD cord-335975-m6lkrehi 621 6 recorded record VBN cord-335975-m6lkrehi 621 7 - - HYPH cord-335975-m6lkrehi 621 8 E e NN cord-335975-m6lkrehi 621 9 wave wave NN cord-335975-m6lkrehi 621 10 , , , cord-335975-m6lkrehi 621 11 A a DT cord-335975-m6lkrehi 621 12 wave wave NN cord-335975-m6lkrehi 621 13 , , , cord-335975-m6lkrehi 621 14 E E NNP cord-335975-m6lkrehi 621 15 A a NN cord-335975-m6lkrehi 622 1 ratio ratio NN cord-335975-m6lkrehi 622 2 , , , cord-335975-m6lkrehi 622 3 velocity velocity NN cord-335975-m6lkrehi 622 4 - - HYPH cord-335975-m6lkrehi 622 5 time time NN cord-335975-m6lkrehi 622 6 integral integral NN cord-335975-m6lkrehi 622 7 ( ( -LRB- cord-335975-m6lkrehi 622 8 VTI VTI NNP cord-335975-m6lkrehi 622 9 ) ) -RRB- cord-335975-m6lkrehi 622 10 , , , cord-335975-m6lkrehi 622 11 Ea Ea NNP cord-335975-m6lkrehi 622 12 wave wave NN cord-335975-m6lkrehi 622 13 and and CC cord-335975-m6lkrehi 622 14 Sa Sa NNP cord-335975-m6lkrehi 622 15 wave wave NN cord-335975-m6lkrehi 622 16 . . . cord-335975-m6lkrehi 623 1 MAP MAP NNP cord-335975-m6lkrehi 623 2 , , , cord-335975-m6lkrehi 623 3 HR HR NNP cord-335975-m6lkrehi 623 4 and and CC cord-335975-m6lkrehi 623 5 TTE TTE NNP cord-335975-m6lkrehi 623 6 variables variable NNS cord-335975-m6lkrehi 623 7 were be VBD cord-335975-m6lkrehi 623 8 collected collect VBN cord-335975-m6lkrehi 623 9 at at IN cord-335975-m6lkrehi 623 10 baseline baseline NN cord-335975-m6lkrehi 623 11 ( ( -LRB- cord-335975-m6lkrehi 623 12 T0 T0 NNP cord-335975-m6lkrehi 623 13 ) ) -RRB- cord-335975-m6lkrehi 623 14 , , , cord-335975-m6lkrehi 623 15 at at IN cord-335975-m6lkrehi 623 16 the the DT cord-335975-m6lkrehi 623 17 end end NN cord-335975-m6lkrehi 623 18 of of IN cord-335975-m6lkrehi 623 19 fluid fluid JJ cord-335975-m6lkrehi 623 20 challenge challenge NN cord-335975-m6lkrehi 623 21 ( ( -LRB- cord-335975-m6lkrehi 623 22 T10 T10 NNP cord-335975-m6lkrehi 623 23 ) ) -RRB- cord-335975-m6lkrehi 623 24 and and CC cord-335975-m6lkrehi 623 25 10 10 CD cord-335975-m6lkrehi 623 26 ( ( -LRB- cord-335975-m6lkrehi 623 27 T20 T20 NNP cord-335975-m6lkrehi 623 28 ) ) -RRB- cord-335975-m6lkrehi 623 29 and and CC cord-335975-m6lkrehi 623 30 20 20 CD cord-335975-m6lkrehi 623 31 min min NN cord-335975-m6lkrehi 623 32 ( ( -LRB- cord-335975-m6lkrehi 623 33 T30 T30 NNP cord-335975-m6lkrehi 623 34 ) ) -RRB- cord-335975-m6lkrehi 623 35 after after IN cord-335975-m6lkrehi 623 36 the the DT cord-335975-m6lkrehi 623 37 end end NN cord-335975-m6lkrehi 623 38 of of IN cord-335975-m6lkrehi 623 39 fluid fluid JJ cord-335975-m6lkrehi 623 40 challenge challenge NN cord-335975-m6lkrehi 623 41 . . . cord-335975-m6lkrehi 624 1 Quantitative quantitative JJ cord-335975-m6lkrehi 624 2 data datum NNS cord-335975-m6lkrehi 624 3 are be VBP cord-335975-m6lkrehi 624 4 expressed express VBN cord-335975-m6lkrehi 624 5 as as IN cord-335975-m6lkrehi 624 6 mean mean JJ cord-335975-m6lkrehi 624 7 and and CC cord-335975-m6lkrehi 624 8 standard standard JJ cord-335975-m6lkrehi 624 9 deviation deviation NN cord-335975-m6lkrehi 624 10 ( ( -LRB- cord-335975-m6lkrehi 624 11 SD sd NN cord-335975-m6lkrehi 624 12 ) ) -RRB- cord-335975-m6lkrehi 624 13 or or CC cord-335975-m6lkrehi 624 14 median median NN cord-335975-m6lkrehi 624 15 and and CC cord-335975-m6lkrehi 624 16 interquartile interquartile JJ cord-335975-m6lkrehi 624 17 ( ( -LRB- cord-335975-m6lkrehi 624 18 IQR IQR NNP cord-335975-m6lkrehi 624 19 ) ) -RRB- cord-335975-m6lkrehi 624 20 , , , cord-335975-m6lkrehi 624 21 according accord VBG cord-335975-m6lkrehi 624 22 to to IN cord-335975-m6lkrehi 624 23 their -PRON- PRP$ cord-335975-m6lkrehi 624 24 distribution distribution NN cord-335975-m6lkrehi 624 25 . . . cord-335975-m6lkrehi 625 1 Qualitative qualitative JJ cord-335975-m6lkrehi 625 2 data datum NNS cord-335975-m6lkrehi 625 3 are be VBP cord-335975-m6lkrehi 625 4 expressed express VBN cord-335975-m6lkrehi 625 5 as as IN cord-335975-m6lkrehi 625 6 absolute absolute JJ cord-335975-m6lkrehi 625 7 number number NN cord-335975-m6lkrehi 625 8 and and CC cord-335975-m6lkrehi 625 9 frequency frequency NN cord-335975-m6lkrehi 625 10 ( ( -LRB- cord-335975-m6lkrehi 625 11 % % NN cord-335975-m6lkrehi 625 12 ) ) -RRB- cord-335975-m6lkrehi 625 13 . . . cord-335975-m6lkrehi 626 1 Results result NNS cord-335975-m6lkrehi 626 2 : : : cord-335975-m6lkrehi 627 1 From from IN cord-335975-m6lkrehi 627 2 May May NNP cord-335975-m6lkrehi 627 3 20th 20th NN cord-335975-m6lkrehi 627 4 2014 2014 CD cord-335975-m6lkrehi 627 5 to to IN cord-335975-m6lkrehi 627 6 January January NNP cord-335975-m6lkrehi 627 7 7th 7th JJ cord-335975-m6lkrehi 627 8 2016 2016 CD cord-335975-m6lkrehi 627 9 , , , cord-335975-m6lkrehi 627 10 a a DT cord-335975-m6lkrehi 627 11 total total NN cord-335975-m6lkrehi 627 12 of of IN cord-335975-m6lkrehi 627 13 143 143 CD cord-335975-m6lkrehi 627 14 patients patient NNS cord-335975-m6lkrehi 627 15 were be VBD cord-335975-m6lkrehi 627 16 enrolled enrol VBN cord-335975-m6lkrehi 627 17 in in IN cord-335975-m6lkrehi 627 18 11 11 CD cord-335975-m6lkrehi 627 19 French french JJ cord-335975-m6lkrehi 627 20 ICUs icu NNS cord-335975-m6lkrehi 627 21 ( ( -LRB- cord-335975-m6lkrehi 627 22 mean mean VB cord-335975-m6lkrehi 627 23 age-64 age-64 NNP cord-335975-m6lkrehi 627 24 ± ± NNP cord-335975-m6lkrehi 627 25 14 14 CD cord-335975-m6lkrehi 627 26 years year NNS cord-335975-m6lkrehi 627 27 , , , cord-335975-m6lkrehi 627 28 median median NN cord-335975-m6lkrehi 627 29 IGS IGS NNP cord-335975-m6lkrehi 627 30 II-53 II-53 NNP cord-335975-m6lkrehi 627 31 , , , cord-335975-m6lkrehi 627 32 median median JJ cord-335975-m6lkrehi 627 33 SOFA sofa NN cord-335975-m6lkrehi 627 34 score-10 score-10 NNS cord-335975-m6lkrehi 627 35 [ [ -LRB- cord-335975-m6lkrehi 627 36 8 8 CD cord-335975-m6lkrehi 627 37 ] ] -RRB- cord-335975-m6lkrehi 627 38 [ [ -LRB- cord-335975-m6lkrehi 627 39 9 9 CD cord-335975-m6lkrehi 627 40 ] ] -RRB- cord-335975-m6lkrehi 627 41 [ [ -LRB- cord-335975-m6lkrehi 627 42 10 10 CD cord-335975-m6lkrehi 627 43 ] ] -RRB- cord-335975-m6lkrehi 627 44 [ [ -LRB- cord-335975-m6lkrehi 627 45 11 11 CD cord-335975-m6lkrehi 627 46 ] ] -RRB- cord-335975-m6lkrehi 627 47 [ [ -LRB- cord-335975-m6lkrehi 627 48 12 12 CD cord-335975-m6lkrehi 627 49 ] ] -RRB- cord-335975-m6lkrehi 627 50 ) ) -RRB- cord-335975-m6lkrehi 627 51 . . . cord-335975-m6lkrehi 628 1 Among among IN cord-335975-m6lkrehi 628 2 the the DT cord-335975-m6lkrehi 628 3 76 76 CD cord-335975-m6lkrehi 628 4 143 143 CD cord-335975-m6lkrehi 628 5 ( ( -LRB- cord-335975-m6lkrehi 628 6 53 53 CD cord-335975-m6lkrehi 628 7 % % NN cord-335975-m6lkrehi 628 8 ) ) -RRB- cord-335975-m6lkrehi 628 9 patients patient NNS cord-335975-m6lkrehi 628 10 responders responder NNS cord-335975-m6lkrehi 628 11 to to IN cord-335975-m6lkrehi 628 12 FC FC NNP cord-335975-m6lkrehi 628 13 at at IN cord-335975-m6lkrehi 628 14 T10 T10 NNP cord-335975-m6lkrehi 628 15 , , , cord-335975-m6lkrehi 628 16 37 37 CD cord-335975-m6lkrehi 628 17 patients patient NNS cord-335975-m6lkrehi 628 18 were be VBD cord-335975-m6lkrehi 628 19 transient transient JJ cord-335975-m6lkrehi 628 20 responders responder NNS cord-335975-m6lkrehi 628 21 ( ( -LRB- cord-335975-m6lkrehi 628 22 TR TR NNP cord-335975-m6lkrehi 628 23 ) ) -RRB- cord-335975-m6lkrehi 628 24 , , , cord-335975-m6lkrehi 628 25 i.e. i.e. FW cord-335975-m6lkrehi 628 26 became become VBD cord-335975-m6lkrehi 628 27 non non JJ cord-335975-m6lkrehi 628 28 - - NNS cord-335975-m6lkrehi 628 29 responders responder NNS cord-335975-m6lkrehi 628 30 at at IN cord-335975-m6lkrehi 628 31 T30 T30 NNP cord-335975-m6lkrehi 628 32 ( ( -LRB- cord-335975-m6lkrehi 628 33 49 49 CD cord-335975-m6lkrehi 628 34 % % NN cord-335975-m6lkrehi 628 35 , , , cord-335975-m6lkrehi 628 36 95 95 CD cord-335975-m6lkrehi 628 37 % % NN cord-335975-m6lkrehi 628 38 CI ci NN cord-335975-m6lkrehi 628 39 = = SYM cord-335975-m6lkrehi 628 40 [ [ -LRB- cord-335975-m6lkrehi 628 41 37 37 CD cord-335975-m6lkrehi 628 42 - - SYM cord-335975-m6lkrehi 628 43 60 60 CD cord-335975-m6lkrehi 628 44 ] ] -RRB- cord-335975-m6lkrehi 628 45 ) ) -RRB- cord-335975-m6lkrehi 628 46 and and CC cord-335975-m6lkrehi 628 47 39 39 CD cord-335975-m6lkrehi 628 48 ( ( -LRB- cord-335975-m6lkrehi 628 49 51 51 CD cord-335975-m6lkrehi 628 50 % % NN cord-335975-m6lkrehi 628 51 , , , cord-335975-m6lkrehi 628 52 95 95 CD cord-335975-m6lkrehi 628 53 % % NN cord-335975-m6lkrehi 628 54 CI ci NN cord-335975-m6lkrehi 628 55 = = NFP cord-335975-m6lkrehi 628 56 [ [ -LRB- cord-335975-m6lkrehi 628 57 38 38 CD cord-335975-m6lkrehi 628 58 - - SYM cord-335975-m6lkrehi 628 59 62 62 CD cord-335975-m6lkrehi 628 60 ] ] -RRB- cord-335975-m6lkrehi 628 61 ) ) -RRB- cord-335975-m6lkrehi 628 62 ) ) -RRB- cord-335975-m6lkrehi 629 1 patients patient NNS cord-335975-m6lkrehi 629 2 were be VBD cord-335975-m6lkrehi 629 3 persistent persistent JJ cord-335975-m6lkrehi 629 4 responders responder NNS cord-335975-m6lkrehi 629 5 ( ( -LRB- cord-335975-m6lkrehi 629 6 PR PR NNP cord-335975-m6lkrehi 629 7 ) ) -RRB- cord-335975-m6lkrehi 629 8 , , , cord-335975-m6lkrehi 629 9 i.e. i.e. FW cord-335975-m6lkrehi 629 10 remained remain VBD cord-335975-m6lkrehi 629 11 responders responder NNS cord-335975-m6lkrehi 629 12 at at IN cord-335975-m6lkrehi 629 13 T30 T30 NNP cord-335975-m6lkrehi 629 14 . . . cord-335975-m6lkrehi 630 1 Among among IN cord-335975-m6lkrehi 630 2 the the DT cord-335975-m6lkrehi 630 3 67 67 CD cord-335975-m6lkrehi 630 4 non non NNS cord-335975-m6lkrehi 630 5 - - NNS cord-335975-m6lkrehi 630 6 responders responder NNS cord-335975-m6lkrehi 630 7 ( ( -LRB- cord-335975-m6lkrehi 630 8 NR NR NNP cord-335975-m6lkrehi 630 9 ) ) -RRB- cord-335975-m6lkrehi 630 10 at at IN cord-335975-m6lkrehi 630 11 T10 T10 NNP cord-335975-m6lkrehi 630 12 , , , cord-335975-m6lkrehi 630 13 4 4 CD cord-335975-m6lkrehi 630 14 became become VBD cord-335975-m6lkrehi 630 15 responders responder NNS cord-335975-m6lkrehi 630 16 at at IN cord-335975-m6lkrehi 630 17 T30 T30 NNP cord-335975-m6lkrehi 630 18 , , , cord-335975-m6lkrehi 630 19 ( ( -LRB- cord-335975-m6lkrehi 630 20 6 6 CD cord-335975-m6lkrehi 630 21 % % NN cord-335975-m6lkrehi 630 22 , , , cord-335975-m6lkrehi 630 23 95 95 CD cord-335975-m6lkrehi 630 24 % % NN cord-335975-m6lkrehi 630 25 CI ci NN cord-335975-m6lkrehi 630 26 = = SYM cord-335975-m6lkrehi 630 27 [ [ -LRB- cord-335975-m6lkrehi 630 28 1.9 1.9 CD cord-335975-m6lkrehi 630 29 - - HYPH cord-335975-m6lkrehi 630 30 15.3 15.3 CD cord-335975-m6lkrehi 630 31 ] ] -RRB- cord-335975-m6lkrehi 630 32 ) ) -RRB- cord-335975-m6lkrehi 630 33 . . . cord-335975-m6lkrehi 631 1 In in IN cord-335975-m6lkrehi 631 2 the the DT cord-335975-m6lkrehi 631 3 subgroup subgroup NN cord-335975-m6lkrehi 631 4 analysis analysis NN cord-335975-m6lkrehi 631 5 , , , cord-335975-m6lkrehi 631 6 no no DT cord-335975-m6lkrehi 631 7 statistical statistical JJ cord-335975-m6lkrehi 631 8 difference difference NN cord-335975-m6lkrehi 631 9 in in IN cord-335975-m6lkrehi 631 10 haemodynamic haemodynamic NNP cord-335975-m6lkrehi 631 11 and and CC cord-335975-m6lkrehi 631 12 echocardiographic echocardiographic JJ cord-335975-m6lkrehi 631 13 parameters parameter NNS cord-335975-m6lkrehi 631 14 was be VBD cord-335975-m6lkrehi 631 15 found find VBN cord-335975-m6lkrehi 631 16 between between IN cord-335975-m6lkrehi 631 17 non non JJ cord-335975-m6lkrehi 631 18 - - NNS cord-335975-m6lkrehi 631 19 responders responder NNS cord-335975-m6lkrehi 631 20 , , , cord-335975-m6lkrehi 631 21 transient transient JJ cord-335975-m6lkrehi 631 22 responders responder NNS cord-335975-m6lkrehi 631 23 and and CC cord-335975-m6lkrehi 631 24 persistent persistent JJ cord-335975-m6lkrehi 631 25 responders responder NNS cord-335975-m6lkrehi 631 26 ( ( -LRB- cord-335975-m6lkrehi 631 27 Fig Fig NNP cord-335975-m6lkrehi 631 28 . . . cord-335975-m6lkrehi 631 29 1 1 CD cord-335975-m6lkrehi 631 30 ) ) -RRB- cord-335975-m6lkrehi 631 31 . . . cord-335975-m6lkrehi 632 1 Conclusion conclusion NN cord-335975-m6lkrehi 632 2 : : : cord-335975-m6lkrehi 633 1 The the DT cord-335975-m6lkrehi 633 2 present present JJ cord-335975-m6lkrehi 633 3 study study NN cord-335975-m6lkrehi 633 4 shows show VBZ cord-335975-m6lkrehi 633 5 that that IN cord-335975-m6lkrehi 633 6 , , , cord-335975-m6lkrehi 633 7 after after IN cord-335975-m6lkrehi 633 8 a a DT cord-335975-m6lkrehi 633 9 15 15 CD cord-335975-m6lkrehi 633 10 % % NN cord-335975-m6lkrehi 633 11 VTI VTI NNP cord-335975-m6lkrehi 633 12 increase increase NN cord-335975-m6lkrehi 633 13 at at IN cord-335975-m6lkrehi 633 14 the the DT cord-335975-m6lkrehi 633 15 end end NN cord-335975-m6lkrehi 633 16 of of IN cord-335975-m6lkrehi 633 17 the the DT cord-335975-m6lkrehi 633 18 FC FC NNP cord-335975-m6lkrehi 633 19 , , , cord-335975-m6lkrehi 633 20 VTI VTI NNP cord-335975-m6lkrehi 633 21 returns return VBZ cord-335975-m6lkrehi 633 22 to to IN cord-335975-m6lkrehi 633 23 baseline baseline VB cord-335975-m6lkrehi 633 24 at at IN cord-335975-m6lkrehi 633 25 30 30 CD cord-335975-m6lkrehi 633 26 min min NN cord-335975-m6lkrehi 633 27 in in IN cord-335975-m6lkrehi 633 28 half half NN cord-335975-m6lkrehi 633 29 of of IN cord-335975-m6lkrehi 633 30 the the DT cord-335975-m6lkrehi 633 31 responders responder NNS cord-335975-m6lkrehi 633 32 . . . cord-335975-m6lkrehi 634 1 Blood blood NN cord-335975-m6lkrehi 634 2 volume volume NN cord-335975-m6lkrehi 634 3 status status NN cord-335975-m6lkrehi 634 4 ( ( -LRB- cord-335975-m6lkrehi 634 5 normo normo NNP cord-335975-m6lkrehi 634 6 or or CC cord-335975-m6lkrehi 634 7 hypovolemia hypovolemia NN cord-335975-m6lkrehi 634 8 ) ) -RRB- cord-335975-m6lkrehi 634 9 before before IN cord-335975-m6lkrehi 634 10 initiating initiate VBG cord-335975-m6lkrehi 634 11 the the DT cord-335975-m6lkrehi 634 12 fluid fluid JJ cord-335975-m6lkrehi 634 13 infusion infusion NN cord-335975-m6lkrehi 634 14 could could MD cord-335975-m6lkrehi 634 15 explain explain VB cord-335975-m6lkrehi 634 16 the the DT cord-335975-m6lkrehi 634 17 transient transient JJ cord-335975-m6lkrehi 634 18 or or CC cord-335975-m6lkrehi 634 19 persistent persistent JJ cord-335975-m6lkrehi 634 20 response response NN cord-335975-m6lkrehi 634 21 to to IN cord-335975-m6lkrehi 634 22 FC FC NNP cord-335975-m6lkrehi 634 23 observed observe VBD cord-335975-m6lkrehi 634 24 in in IN cord-335975-m6lkrehi 634 25 septic septic JJ cord-335975-m6lkrehi 634 26 patients patient NNS cord-335975-m6lkrehi 634 27 . . . cord-335975-m6lkrehi 635 1 Mottling Mottling NNP cord-335975-m6lkrehi 635 2 score score NN cord-335975-m6lkrehi 635 3 is be VBZ cord-335975-m6lkrehi 635 4 a a DT cord-335975-m6lkrehi 635 5 strong strong JJ cord-335975-m6lkrehi 635 6 predictor predictor NN cord-335975-m6lkrehi 635 7 of of IN cord-335975-m6lkrehi 635 8 Day-14 Day-14 NNP cord-335975-m6lkrehi 635 9 mortality mortality NN cord-335975-m6lkrehi 635 10 in in IN cord-335975-m6lkrehi 635 11 sepsis sepsis NN cord-335975-m6lkrehi 635 12 patients patient NNS cord-335975-m6lkrehi 635 13 independently independently RB cord-335975-m6lkrehi 635 14 of of IN cord-335975-m6lkrehi 635 15 catecholamine catecholamine NN cord-335975-m6lkrehi 635 16 dosing dosing NN cord-335975-m6lkrehi 635 17 and and CC cord-335975-m6lkrehi 635 18 other other JJ cord-335975-m6lkrehi 635 19 tissue tissue NN cord-335975-m6lkrehi 635 20 hypoperfusion hypoperfusion NN cord-335975-m6lkrehi 635 21 parameters parameter NNS cord-335975-m6lkrehi 635 22 Dumas Dumas NNP cord-335975-m6lkrehi 635 23 Guillaume Guillaume NNP cord-335975-m6lkrehi 635 24 1 1 CD cord-335975-m6lkrehi 635 25 , , , cord-335975-m6lkrehi 635 26 Joffre Joffre NNP cord-335975-m6lkrehi 635 27 Jérémie Jérémie NNP cord-335975-m6lkrehi 635 28 1 1 CD cord-335975-m6lkrehi 635 29 , , , cord-335975-m6lkrehi 635 30 Hariri Hariri NNP cord-335975-m6lkrehi 635 31 Geoffroy Geoffroy NNP cord-335975-m6lkrehi 635 32 1 1 CD cord-335975-m6lkrehi 635 33 , , , cord-335975-m6lkrehi 635 34 Bigé Bigé NNP cord-335975-m6lkrehi 635 35 Naike Naike NNP cord-335975-m6lkrehi 635 36 1 1 CD cord-335975-m6lkrehi 635 37 , , , cord-335975-m6lkrehi 635 38 Baudel Baudel NNP cord-335975-m6lkrehi 635 39 Introduction introduction NN cord-335975-m6lkrehi 635 40 : : : cord-335975-m6lkrehi 636 1 Sepsis sepsis NN cord-335975-m6lkrehi 636 2 is be VBZ cord-335975-m6lkrehi 636 3 a a DT cord-335975-m6lkrehi 636 4 frequent frequent JJ cord-335975-m6lkrehi 636 5 critical critical JJ cord-335975-m6lkrehi 636 6 condition condition NN cord-335975-m6lkrehi 636 7 . . . cord-335975-m6lkrehi 637 1 Mottling Mottling NNP cord-335975-m6lkrehi 637 2 score score NN cord-335975-m6lkrehi 637 3 , , , cord-335975-m6lkrehi 637 4 an an DT cord-335975-m6lkrehi 637 5 hypoperfusion hypoperfusion NN cord-335975-m6lkrehi 637 6 parameter parameter NN cord-335975-m6lkrehi 637 7 , , , cord-335975-m6lkrehi 637 8 is be VBZ cord-335975-m6lkrehi 637 9 well well RB cord-335975-m6lkrehi 637 10 correlated correlate VBN cord-335975-m6lkrehi 637 11 with with IN cord-335975-m6lkrehi 637 12 outcome outcome NN cord-335975-m6lkrehi 637 13 . . . cord-335975-m6lkrehi 638 1 However however RB cord-335975-m6lkrehi 638 2 , , , cord-335975-m6lkrehi 638 3 uncertainties uncertainty NNS cord-335975-m6lkrehi 638 4 persist persist VBP cord-335975-m6lkrehi 638 5 regarding regard VBG cord-335975-m6lkrehi 638 6 its -PRON- PRP$ cord-335975-m6lkrehi 638 7 value value NN cord-335975-m6lkrehi 638 8 not not RB cord-335975-m6lkrehi 638 9 only only RB cord-335975-m6lkrehi 638 10 as as IN cord-335975-m6lkrehi 638 11 a a DT cord-335975-m6lkrehi 638 12 marker marker NN cord-335975-m6lkrehi 638 13 of of IN cord-335975-m6lkrehi 638 14 patient patient JJ cord-335975-m6lkrehi 638 15 severity severity NN cord-335975-m6lkrehi 638 16 but but CC cord-335975-m6lkrehi 638 17 also also RB cord-335975-m6lkrehi 638 18 as as IN cord-335975-m6lkrehi 638 19 an an DT cord-335975-m6lkrehi 638 20 independent independent JJ cord-335975-m6lkrehi 638 21 predictor predictor NN cord-335975-m6lkrehi 638 22 of of IN cord-335975-m6lkrehi 638 23 mortality mortality NN cord-335975-m6lkrehi 638 24 and and CC cord-335975-m6lkrehi 638 25 treatment treatment NN cord-335975-m6lkrehi 638 26 efficacy efficacy NN cord-335975-m6lkrehi 638 27 . . . cord-335975-m6lkrehi 639 1 We -PRON- PRP cord-335975-m6lkrehi 639 2 performed perform VBD cord-335975-m6lkrehi 639 3 a a DT cord-335975-m6lkrehi 639 4 post post FW cord-335975-m6lkrehi 639 5 hoc hoc FW cord-335975-m6lkrehi 639 6 analysis analysis NN cord-335975-m6lkrehi 639 7 of of IN cord-335975-m6lkrehi 639 8 four four CD cord-335975-m6lkrehi 639 9 published publish VBN cord-335975-m6lkrehi 639 10 prospective prospective JJ cord-335975-m6lkrehi 639 11 studies study NNS cord-335975-m6lkrehi 639 12 including include VBG cord-335975-m6lkrehi 639 13 sepsis sepsis NN cord-335975-m6lkrehi 639 14 patients patient NNS cord-335975-m6lkrehi 639 15 with with IN cord-335975-m6lkrehi 639 16 or or CC cord-335975-m6lkrehi 639 17 without without IN cord-335975-m6lkrehi 639 18 shock shock NN cord-335975-m6lkrehi 639 19 . . . cord-335975-m6lkrehi 640 1 We -PRON- PRP cord-335975-m6lkrehi 640 2 analyzed analyze VBD cord-335975-m6lkrehi 640 3 the the DT cord-335975-m6lkrehi 640 4 relationship relationship NN cord-335975-m6lkrehi 640 5 between between IN cord-335975-m6lkrehi 640 6 the the DT cord-335975-m6lkrehi 640 7 mottling mottling NN cord-335975-m6lkrehi 640 8 score score NN cord-335975-m6lkrehi 640 9 ( ( -LRB- cord-335975-m6lkrehi 640 10 from from IN cord-335975-m6lkrehi 640 11 0 0 CD cord-335975-m6lkrehi 640 12 to to IN cord-335975-m6lkrehi 640 13 5 5 CD cord-335975-m6lkrehi 640 14 ) ) -RRB- cord-335975-m6lkrehi 640 15 and and CC cord-335975-m6lkrehi 640 16 Day-14 Day-14 NNP cord-335975-m6lkrehi 640 17 mortality mortality NN cord-335975-m6lkrehi 640 18 according accord VBG cord-335975-m6lkrehi 640 19 to to IN cord-335975-m6lkrehi 640 20 other other JJ cord-335975-m6lkrehi 640 21 prognosis prognosis NN cord-335975-m6lkrehi 640 22 covariates covariate NNS cord-335975-m6lkrehi 640 23 such such JJ cord-335975-m6lkrehi 640 24 as as IN cord-335975-m6lkrehi 640 25 catecholamine catecholamine NN cord-335975-m6lkrehi 640 26 dosing dosing NN cord-335975-m6lkrehi 640 27 , , , cord-335975-m6lkrehi 640 28 urine urine NN cord-335975-m6lkrehi 640 29 output output NN cord-335975-m6lkrehi 640 30 and and CC cord-335975-m6lkrehi 640 31 plasma plasma NN cord-335975-m6lkrehi 640 32 lactate lactate NN cord-335975-m6lkrehi 640 33 levels level NNS cord-335975-m6lkrehi 640 34 . . . cord-335975-m6lkrehi 641 1 First first RB cord-335975-m6lkrehi 641 2 , , , cord-335975-m6lkrehi 641 3 factors factor NNS cord-335975-m6lkrehi 641 4 associated associate VBN cord-335975-m6lkrehi 641 5 with with IN cord-335975-m6lkrehi 641 6 outcome outcome NN cord-335975-m6lkrehi 641 7 were be VBD cord-335975-m6lkrehi 641 8 determined determine VBN cord-335975-m6lkrehi 641 9 by by IN cord-335975-m6lkrehi 641 10 multivariate multivariate JJ cord-335975-m6lkrehi 641 11 analysis analysis NN cord-335975-m6lkrehi 641 12 . . . cord-335975-m6lkrehi 642 1 Second second RB cord-335975-m6lkrehi 642 2 , , , cord-335975-m6lkrehi 642 3 mottling mottling NN cord-335975-m6lkrehi 642 4 score score NN cord-335975-m6lkrehi 642 5 - - HYPH cord-335975-m6lkrehi 642 6 by by IN cord-335975-m6lkrehi 642 7 - - HYPH cord-335975-m6lkrehi 642 8 covariate covariate NN cord-335975-m6lkrehi 642 9 interaction interaction NN cord-335975-m6lkrehi 642 10 was be VBD cord-335975-m6lkrehi 642 11 studied study VBN cord-335975-m6lkrehi 642 12 to to TO cord-335975-m6lkrehi 642 13 better well RBR cord-335975-m6lkrehi 642 14 understand understand VB cord-335975-m6lkrehi 642 15 its -PRON- PRP$ cord-335975-m6lkrehi 642 16 effect effect NN cord-335975-m6lkrehi 642 17 on on IN cord-335975-m6lkrehi 642 18 mortality mortality NN cord-335975-m6lkrehi 642 19 . . . cord-335975-m6lkrehi 643 1 Finally finally RB cord-335975-m6lkrehi 643 2 , , , cord-335975-m6lkrehi 643 3 effect effect NN cord-335975-m6lkrehi 643 4 of of IN cord-335975-m6lkrehi 643 5 mottling mottling NN cord-335975-m6lkrehi 643 6 score score NN cord-335975-m6lkrehi 643 7 variation variation NN cord-335975-m6lkrehi 643 8 at at IN cord-335975-m6lkrehi 643 9 different different JJ cord-335975-m6lkrehi 643 10 time time NN cord-335975-m6lkrehi 643 11 point point NN cord-335975-m6lkrehi 643 12 ( ( -LRB- cord-335975-m6lkrehi 643 13 H0-H6-H12-H24 H0-H6-H12-H24 NNP cord-335975-m6lkrehi 643 14 ) ) -RRB- cord-335975-m6lkrehi 643 15 was be VBD cord-335975-m6lkrehi 643 16 assessed assess VBN cord-335975-m6lkrehi 643 17 . . . cord-335975-m6lkrehi 644 1 whereas whereas IN cord-335975-m6lkrehi 644 2 ECMO ECMO NNP cord-335975-m6lkrehi 644 3 was be VBD cord-335975-m6lkrehi 644 4 successfully successfully RB cord-335975-m6lkrehi 644 5 weaned wean VBN cord-335975-m6lkrehi 644 6 in in IN cord-335975-m6lkrehi 644 7 6 6 CD cord-335975-m6lkrehi 644 8 ( ( -LRB- cord-335975-m6lkrehi 644 9 33 33 CD cord-335975-m6lkrehi 644 10 % % NN cord-335975-m6lkrehi 644 11 ) ) -RRB- cord-335975-m6lkrehi 644 12 patients patient NNS cord-335975-m6lkrehi 644 13 . . . cord-335975-m6lkrehi 645 1 Proportion proportion NN cord-335975-m6lkrehi 645 2 of of IN cord-335975-m6lkrehi 645 3 Perfused Perfused NNP cord-335975-m6lkrehi 645 4 Vessel Vessel NNP cord-335975-m6lkrehi 645 5 ( ( -LRB- cord-335975-m6lkrehi 645 6 PPV PPV NNP cord-335975-m6lkrehi 645 7 ) ) -RRB- cord-335975-m6lkrehi 645 8 , , , cord-335975-m6lkrehi 645 9 Perfused Perfused NNP cord-335975-m6lkrehi 645 10 Vessel Vessel NNP cord-335975-m6lkrehi 645 11 Density Density NNP cord-335975-m6lkrehi 645 12 ( ( -LRB- cord-335975-m6lkrehi 645 13 PVD PVD NNP cord-335975-m6lkrehi 645 14 ) ) -RRB- cord-335975-m6lkrehi 645 15 , , , cord-335975-m6lkrehi 645 16 Micro Micro NNP cord-335975-m6lkrehi 645 17 Flow Flow NNP cord-335975-m6lkrehi 645 18 Index Index NNP cord-335975-m6lkrehi 645 19 ( ( -LRB- cord-335975-m6lkrehi 645 20 MFI MFI NNP cord-335975-m6lkrehi 645 21 ) ) -RRB- cord-335975-m6lkrehi 645 22 and and CC cord-335975-m6lkrehi 645 23 Heterogeneity Heterogeneity NNP cord-335975-m6lkrehi 645 24 Index Index NNP cord-335975-m6lkrehi 645 25 ( ( -LRB- cord-335975-m6lkrehi 645 26 HI HI NNP cord-335975-m6lkrehi 645 27 ) ) -RRB- cord-335975-m6lkrehi 645 28 were be VBD cord-335975-m6lkrehi 645 29 severely severely RB cord-335975-m6lkrehi 645 30 impaired impair VBN cord-335975-m6lkrehi 645 31 before before IN cord-335975-m6lkrehi 645 32 ECMO ECMO NNP cord-335975-m6lkrehi 645 33 . . . cord-335975-m6lkrehi 646 1 Re Re VBG cord-335975-m6lkrehi 646 2 - - VBG cord-335975-m6lkrehi 646 3 establishing establish VBG cord-335975-m6lkrehi 646 4 high high JJ cord-335975-m6lkrehi 646 5 and and CC cord-335975-m6lkrehi 646 6 stable stable JJ cord-335975-m6lkrehi 646 7 peripheral peripheral JJ cord-335975-m6lkrehi 646 8 blood blood NN cord-335975-m6lkrehi 646 9 flow flow NN cord-335975-m6lkrehi 646 10 with with IN cord-335975-m6lkrehi 646 11 VA VA NNP cord-335975-m6lkrehi 646 12 - - HYPH cord-335975-m6lkrehi 646 13 ECMO ECMO NNP cord-335975-m6lkrehi 646 14 led lead VBD cord-335975-m6lkrehi 646 15 to to IN cord-335975-m6lkrehi 646 16 a a DT cord-335975-m6lkrehi 646 17 rapid rapid JJ cord-335975-m6lkrehi 646 18 decrease decrease NN cord-335975-m6lkrehi 646 19 in in IN cord-335975-m6lkrehi 646 20 heart heart NN cord-335975-m6lkrehi 646 21 rate rate NN cord-335975-m6lkrehi 646 22 and and CC cord-335975-m6lkrehi 646 23 vasoactive vasoactive JJ cord-335975-m6lkrehi 646 24 inotropic inotropic JJ cord-335975-m6lkrehi 646 25 support support NN cord-335975-m6lkrehi 646 26 and and CC cord-335975-m6lkrehi 646 27 significantly significantly RB cord-335975-m6lkrehi 646 28 improved improve VBD cord-335975-m6lkrehi 646 29 all all DT cord-335975-m6lkrehi 646 30 microcirculation microcirculation NN cord-335975-m6lkrehi 646 31 parameters parameter NNS cord-335975-m6lkrehi 646 32 within within IN cord-335975-m6lkrehi 646 33 12 12 CD cord-335975-m6lkrehi 646 34 h. h. NN cord-335975-m6lkrehi 646 35 Total total JJ cord-335975-m6lkrehi 646 36 vessel vessel NN cord-335975-m6lkrehi 646 37 density density NN cord-335975-m6lkrehi 646 38 and and CC cord-335975-m6lkrehi 646 39 PVD PVD NNP cord-335975-m6lkrehi 646 40 , , , cord-335975-m6lkrehi 646 41 measured measure VBN cord-335975-m6lkrehi 646 42 before before RB cord-335975-m6lkrehi 646 43 and and CC cord-335975-m6lkrehi 646 44 after after IN cord-335975-m6lkrehi 646 45 ECMO ECMO NNP cord-335975-m6lkrehi 646 46 initiation initiation NN cord-335975-m6lkrehi 646 47 , , , cord-335975-m6lkrehi 646 48 were be VBD cord-335975-m6lkrehi 646 49 better well JJR cord-335975-m6lkrehi 646 50 in in IN cord-335975-m6lkrehi 646 51 patients patient NNS cord-335975-m6lkrehi 646 52 successfully successfully RB cord-335975-m6lkrehi 646 53 weaned wean VBN cord-335975-m6lkrehi 646 54 from from IN cord-335975-m6lkrehi 646 55 ECMO ECMO NNP cord-335975-m6lkrehi 646 56 ( ( -LRB- cord-335975-m6lkrehi 646 57 p p NN cord-335975-m6lkrehi 646 58 < < XX cord-335975-m6lkrehi 646 59 0.05 0.05 CD cord-335975-m6lkrehi 646 60 ) ) -RRB- cord-335975-m6lkrehi 647 1 ( ( -LRB- cord-335975-m6lkrehi 647 2 Fig Fig NNP cord-335975-m6lkrehi 647 3 . . . cord-335975-m6lkrehi 648 1 1 1 LS cord-335975-m6lkrehi 648 2 ) ) -RRB- cord-335975-m6lkrehi 648 3 . . . cord-335975-m6lkrehi 649 1 Conclusion conclusion NN cord-335975-m6lkrehi 649 2 : : : cord-335975-m6lkrehi 650 1 Cardiovascular cardiovascular JJ cord-335975-m6lkrehi 650 2 support support NN cord-335975-m6lkrehi 650 3 with with IN cord-335975-m6lkrehi 650 4 ECMO ECMO NNP cord-335975-m6lkrehi 650 5 - - HYPH cord-335975-m6lkrehi 650 6 VA VA NNP cord-335975-m6lkrehi 650 7 rapidly rapidly RB cord-335975-m6lkrehi 650 8 improved improve VBD cord-335975-m6lkrehi 650 9 macro macro NN cord-335975-m6lkrehi 650 10 and and CC cord-335975-m6lkrehi 650 11 microcirculation microcirculation NN cord-335975-m6lkrehi 650 12 in in IN cord-335975-m6lkrehi 650 13 refractory refractory JJ cord-335975-m6lkrehi 650 14 cardiogenic cardiogenic JJ cord-335975-m6lkrehi 650 15 shock shock NN cord-335975-m6lkrehi 650 16 patients patient NNS cord-335975-m6lkrehi 650 17 . . . cord-335975-m6lkrehi 651 1 Total total JJ cord-335975-m6lkrehi 651 2 vessel vessel NN cord-335975-m6lkrehi 651 3 density density NN cord-335975-m6lkrehi 651 4 and and CC cord-335975-m6lkrehi 651 5 perfused perfuse VBN cord-335975-m6lkrehi 651 6 vessel vessel NN cord-335975-m6lkrehi 651 7 density density NN cord-335975-m6lkrehi 651 8 were be VBD cord-335975-m6lkrehi 651 9 significantly significantly RB cord-335975-m6lkrehi 651 10 better well JJR cord-335975-m6lkrehi 651 11 in in IN cord-335975-m6lkrehi 651 12 survivors survivor NNS cord-335975-m6lkrehi 651 13 12 12 CD cord-335975-m6lkrehi 651 14 h h NN cord-335975-m6lkrehi 651 15 after after IN cord-335975-m6lkrehi 651 16 ECMO ECMO NNP cord-335975-m6lkrehi 651 17 initiation initiation NN cord-335975-m6lkrehi 651 18 and and CC cord-335975-m6lkrehi 651 19 might may MD cord-335975-m6lkrehi 651 20 therefore therefore RB cord-335975-m6lkrehi 651 21 help help VB cord-335975-m6lkrehi 651 22 to to TO cord-335975-m6lkrehi 651 23 predict predict VB cord-335975-m6lkrehi 651 24 outcomes outcome NNS cord-335975-m6lkrehi 651 25 . . . cord-335975-m6lkrehi 652 1 Further further JJ cord-335975-m6lkrehi 652 2 studies study NNS cord-335975-m6lkrehi 652 3 are be VBP cord-335975-m6lkrehi 652 4 now now RB cord-335975-m6lkrehi 652 5 needed need VBN cord-335975-m6lkrehi 652 6 to to TO cord-335975-m6lkrehi 652 7 better better RB cord-335975-m6lkrehi 652 8 define define VB cord-335975-m6lkrehi 652 9 the the DT cord-335975-m6lkrehi 652 10 utility utility NN cord-335975-m6lkrehi 652 11 of of IN cord-335975-m6lkrehi 652 12 this this DT cord-335975-m6lkrehi 652 13 technology technology NN cord-335975-m6lkrehi 652 14 in in IN cord-335975-m6lkrehi 652 15 larger large JJR cord-335975-m6lkrehi 652 16 groups group NNS cord-335975-m6lkrehi 652 17 of of IN cord-335975-m6lkrehi 652 18 VA VA NNP cord-335975-m6lkrehi 652 19 - - HYPH cord-335975-m6lkrehi 652 20 ECMO ECMO NNP cord-335975-m6lkrehi 652 21 patients patient NNS cord-335975-m6lkrehi 652 22 . . . cord-335975-m6lkrehi 653 1 Introduction introduction NN cord-335975-m6lkrehi 653 2 : : : cord-335975-m6lkrehi 654 1 Thyroid thyroid JJ cord-335975-m6lkrehi 654 2 storm storm NN cord-335975-m6lkrehi 654 3 is be VBZ cord-335975-m6lkrehi 654 4 a a DT cord-335975-m6lkrehi 654 5 rare rare JJ cord-335975-m6lkrehi 654 6 but but CC cord-335975-m6lkrehi 654 7 life life NN cord-335975-m6lkrehi 654 8 - - HYPH cord-335975-m6lkrehi 654 9 threatening threaten VBG cord-335975-m6lkrehi 654 10 disease disease NN cord-335975-m6lkrehi 654 11 related relate VBN cord-335975-m6lkrehi 654 12 to to IN cord-335975-m6lkrehi 654 13 thyrotoxicosis thyrotoxicosis NNP cord-335975-m6lkrehi 654 14 . . . cord-335975-m6lkrehi 655 1 It -PRON- PRP cord-335975-m6lkrehi 655 2 can can MD cord-335975-m6lkrehi 655 3 lead lead VB cord-335975-m6lkrehi 655 4 to to IN cord-335975-m6lkrehi 655 5 multiple multiple JJ cord-335975-m6lkrehi 655 6 organ organ NN cord-335975-m6lkrehi 655 7 failure failure NN cord-335975-m6lkrehi 655 8 including include VBG cord-335975-m6lkrehi 655 9 cardiovascular cardiovascular JJ cord-335975-m6lkrehi 655 10 disorders disorder NNS cord-335975-m6lkrehi 655 11 or or CC cord-335975-m6lkrehi 655 12 neurological neurological JJ cord-335975-m6lkrehi 655 13 impairment impairment NN cord-335975-m6lkrehi 655 14 . . . cord-335975-m6lkrehi 656 1 To to IN cord-335975-m6lkrehi 656 2 date date NN cord-335975-m6lkrehi 656 3 , , , cord-335975-m6lkrehi 656 4 data datum NNS cord-335975-m6lkrehi 656 5 on on IN cord-335975-m6lkrehi 656 6 this this DT cord-335975-m6lkrehi 656 7 disease disease NN cord-335975-m6lkrehi 656 8 in in IN cord-335975-m6lkrehi 656 9 ICU ICU NNP cord-335975-m6lkrehi 656 10 patients patient NNS cord-335975-m6lkrehi 656 11 are be VBP cord-335975-m6lkrehi 656 12 scarce scarce JJ cord-335975-m6lkrehi 656 13 and and CC cord-335975-m6lkrehi 656 14 limited limit VBN cord-335975-m6lkrehi 656 15 to to IN cord-335975-m6lkrehi 656 16 case case NN cord-335975-m6lkrehi 656 17 reports report NNS cord-335975-m6lkrehi 656 18 . . . cord-335975-m6lkrehi 657 1 We -PRON- PRP cord-335975-m6lkrehi 657 2 therefore therefore RB cord-335975-m6lkrehi 657 3 aimed aim VBD cord-335975-m6lkrehi 657 4 to to TO cord-335975-m6lkrehi 657 5 describe describe VB cord-335975-m6lkrehi 657 6 clinical clinical JJ cord-335975-m6lkrehi 657 7 presentation presentation NN cord-335975-m6lkrehi 657 8 , , , cord-335975-m6lkrehi 657 9 outcomes outcome NNS cord-335975-m6lkrehi 657 10 and and CC cord-335975-m6lkrehi 657 11 management management NN cord-335975-m6lkrehi 657 12 of of IN cord-335975-m6lkrehi 657 13 thyroid thyroid JJ cord-335975-m6lkrehi 657 14 storm storm NN cord-335975-m6lkrehi 657 15 in in IN cord-335975-m6lkrehi 657 16 ICU ICU NNP cord-335975-m6lkrehi 657 17 patients patient NNS cord-335975-m6lkrehi 657 18 . . . cord-335975-m6lkrehi 658 1 Patients patient NNS cord-335975-m6lkrehi 658 2 and and CC cord-335975-m6lkrehi 658 3 methods method NNS cord-335975-m6lkrehi 658 4 : : : cord-335975-m6lkrehi 658 5 Local local JJ cord-335975-m6lkrehi 658 6 diagnoses diagnosis NNS cord-335975-m6lkrehi 658 7 coding code VBG cord-335975-m6lkrehi 658 8 database database NN cord-335975-m6lkrehi 658 9 ( ( -LRB- cord-335975-m6lkrehi 658 10 from from IN cord-335975-m6lkrehi 658 11 January January NNP cord-335975-m6lkrehi 658 12 2000 2000 CD cord-335975-m6lkrehi 658 13 to to IN cord-335975-m6lkrehi 658 14 July July NNP cord-335975-m6lkrehi 658 15 2017 2017 CD cord-335975-m6lkrehi 658 16 ) ) -RRB- cord-335975-m6lkrehi 658 17 from from IN cord-335975-m6lkrehi 658 18 22 22 CD cord-335975-m6lkrehi 658 19 French French NNP cord-335975-m6lkrehi 658 20 ICU ICU NNP cord-335975-m6lkrehi 658 21 were be VBD cord-335975-m6lkrehi 658 22 interrogated interrogate VBN cord-335975-m6lkrehi 658 23 for for IN cord-335975-m6lkrehi 658 24 main main JJ cord-335975-m6lkrehi 658 25 and and CC cord-335975-m6lkrehi 658 26 secondary secondary JJ cord-335975-m6lkrehi 658 27 diagnoses diagnosis NNS cord-335975-m6lkrehi 658 28 codes code NNS cord-335975-m6lkrehi 658 29 including include VBG cord-335975-m6lkrehi 658 30 thyrotoxicosis thyrotoxicosis NN cord-335975-m6lkrehi 658 31 based base VBN cord-335975-m6lkrehi 658 32 on on IN cord-335975-m6lkrehi 658 33 the the DT cord-335975-m6lkrehi 658 34 International International NNP cord-335975-m6lkrehi 658 35 Classification Classification NNP cord-335975-m6lkrehi 658 36 of of IN cord-335975-m6lkrehi 658 37 Disease Disease NNP cord-335975-m6lkrehi 658 38 10th 10th JJ cord-335975-m6lkrehi 658 39 revision revision NN cord-335975-m6lkrehi 658 40 . . . cord-335975-m6lkrehi 659 1 Thereafter thereafter RB cord-335975-m6lkrehi 659 2 two two CD cord-335975-m6lkrehi 659 3 investigators investigator NNS cord-335975-m6lkrehi 659 4 reviewed review VBD cord-335975-m6lkrehi 659 5 all all PDT cord-335975-m6lkrehi 659 6 the the DT cord-335975-m6lkrehi 659 7 medical medical JJ cord-335975-m6lkrehi 659 8 records record NNS cord-335975-m6lkrehi 659 9 selected select VBN cord-335975-m6lkrehi 659 10 . . . cord-335975-m6lkrehi 660 1 Inclusion inclusion NN cord-335975-m6lkrehi 660 2 criteria criterion NNS cord-335975-m6lkrehi 660 3 were be VBD cord-335975-m6lkrehi 660 4 thyroid thyroid JJ cord-335975-m6lkrehi 660 5 storm storm NN cord-335975-m6lkrehi 660 6 based base VBN cord-335975-m6lkrehi 660 7 on on IN cord-335975-m6lkrehi 660 8 the the DT cord-335975-m6lkrehi 660 9 diagnostic diagnostic JJ cord-335975-m6lkrehi 660 10 criteria criterion NNS cord-335975-m6lkrehi 660 11 of of IN cord-335975-m6lkrehi 660 12 the the DT cord-335975-m6lkrehi 660 13 Japan Japan NNP cord-335975-m6lkrehi 660 14 Thyroid Thyroid NNP cord-335975-m6lkrehi 660 15 Association Association NNP cord-335975-m6lkrehi 660 16 ( ( -LRB- cord-335975-m6lkrehi 660 17 T. T. NNP cord-335975-m6lkrehi 660 18 Satoh Satoh NNP cord-335975-m6lkrehi 660 19 , , , cord-335975-m6lkrehi 660 20 Endocrine Endocrine NNP cord-335975-m6lkrehi 660 21 Journal Journal NNP cord-335975-m6lkrehi 660 22 2016 2016 CD cord-335975-m6lkrehi 660 23 ) ) -RRB- cord-335975-m6lkrehi 660 24 . . . cord-335975-m6lkrehi 661 1 It -PRON- PRP cord-335975-m6lkrehi 661 2 combines combine VBZ cord-335975-m6lkrehi 661 3 thyrotoxicosis thyrotoxicosis NN cord-335975-m6lkrehi 661 4 with with IN cord-335975-m6lkrehi 661 5 elevated elevated JJ cord-335975-m6lkrehi 661 6 levels level NNS cord-335975-m6lkrehi 661 7 of of IN cord-335975-m6lkrehi 661 8 free free JJ cord-335975-m6lkrehi 661 9 triiodothyronine triiodothyronine NN cord-335975-m6lkrehi 661 10 ( ( -LRB- cord-335975-m6lkrehi 661 11 FT3 FT3 NNP cord-335975-m6lkrehi 661 12 ) ) -RRB- cord-335975-m6lkrehi 661 13 or or CC cord-335975-m6lkrehi 661 14 free free JJ cord-335975-m6lkrehi 661 15 thyroxine thyroxine NN cord-335975-m6lkrehi 661 16 ( ( -LRB- cord-335975-m6lkrehi 661 17 FT4 FT4 NNP cord-335975-m6lkrehi 661 18 ) ) -RRB- cord-335975-m6lkrehi 661 19 with with IN cord-335975-m6lkrehi 661 20 at at RB cord-335975-m6lkrehi 661 21 least least RBS cord-335975-m6lkrehi 661 22 two two CD cord-335975-m6lkrehi 661 23 of of IN cord-335975-m6lkrehi 661 24 the the DT cord-335975-m6lkrehi 661 25 following follow VBG cord-335975-m6lkrehi 661 26 symptoms symptom NNS cord-335975-m6lkrehi 661 27 - - HYPH cord-335975-m6lkrehi 661 28 central central JJ cord-335975-m6lkrehi 661 29 nervous nervous JJ cord-335975-m6lkrehi 661 30 system system NN cord-335975-m6lkrehi 661 31 manifestation manifestation NN cord-335975-m6lkrehi 661 32 , , , cord-335975-m6lkrehi 661 33 fever fever NN cord-335975-m6lkrehi 661 34 , , , cord-335975-m6lkrehi 661 35 tachycardia tachycardia NN cord-335975-m6lkrehi 661 36 > > XX cord-335975-m6lkrehi 661 37 130 130 CD cord-335975-m6lkrehi 661 38 bpm bpm NN cord-335975-m6lkrehi 661 39 , , , cord-335975-m6lkrehi 661 40 congestive congestive JJ cord-335975-m6lkrehi 661 41 heart heart NN cord-335975-m6lkrehi 661 42 failure failure NN cord-335975-m6lkrehi 661 43 , , , cord-335975-m6lkrehi 661 44 or or CC cord-335975-m6lkrehi 661 45 total total JJ cord-335975-m6lkrehi 661 46 bilirubin bilirubin NN cord-335975-m6lkrehi 661 47 level level NN cord-335975-m6lkrehi 662 1 more more JJR cord-335975-m6lkrehi 662 2 than than IN cord-335975-m6lkrehi 662 3 50 50 CD cord-335975-m6lkrehi 662 4 micromol micromol JJ cord-335975-m6lkrehi 662 5 / / SYM cord-335975-m6lkrehi 662 6 l l NN cord-335975-m6lkrehi 662 7 . . . cord-335975-m6lkrehi 663 1 Clinical clinical JJ cord-335975-m6lkrehi 663 2 presentation presentation NN cord-335975-m6lkrehi 663 3 , , , cord-335975-m6lkrehi 663 4 therapy therapy NN cord-335975-m6lkrehi 663 5 used use VBD cord-335975-m6lkrehi 663 6 , , , cord-335975-m6lkrehi 663 7 and and CC cord-335975-m6lkrehi 663 8 outcome outcome NN cord-335975-m6lkrehi 663 9 were be VBD cord-335975-m6lkrehi 663 10 recorded record VBN cord-335975-m6lkrehi 663 11 . . . cord-335975-m6lkrehi 664 1 Results result NNS cord-335975-m6lkrehi 664 2 : : : cord-335975-m6lkrehi 665 1 Sixty sixty CD cord-335975-m6lkrehi 665 2 - - HYPH cord-335975-m6lkrehi 665 3 two two CD cord-335975-m6lkrehi 665 4 patients patient NNS cord-335975-m6lkrehi 665 5 ( ( -LRB- cord-335975-m6lkrehi 665 6 median median JJ cord-335975-m6lkrehi 665 7 age age NN cord-335975-m6lkrehi 665 8 57 57 CD cord-335975-m6lkrehi 665 9 years year NNS cord-335975-m6lkrehi 665 10 ( ( -LRB- cord-335975-m6lkrehi 665 11 interquartile interquartile JJ cord-335975-m6lkrehi 665 12 range range VBP cord-335975-m6lkrehi 665 13 44 44 CD cord-335975-m6lkrehi 665 14 - - SYM cord-335975-m6lkrehi 665 15 67 67 CD cord-335975-m6lkrehi 665 16 ) ) -RRB- cord-335975-m6lkrehi 666 1 + + NFP cord-335975-m6lkrehi 666 2 SAPS SAPS NNP cord-335975-m6lkrehi 666 3 II II NNP cord-335975-m6lkrehi 666 4 45 45 CD cord-335975-m6lkrehi 666 5 ( ( -LRB- cord-335975-m6lkrehi 666 6 32 32 CD cord-335975-m6lkrehi 666 7 - - SYM cord-335975-m6lkrehi 666 8 66 66 CD cord-335975-m6lkrehi 666 9 ) ) -RRB- cord-335975-m6lkrehi 666 10 were be VBD cord-335975-m6lkrehi 666 11 included include VBN cord-335975-m6lkrehi 666 12 . . . cord-335975-m6lkrehi 667 1 Thyroid thyroid JJ cord-335975-m6lkrehi 667 2 storm storm NN cord-335975-m6lkrehi 667 3 was be VBD cord-335975-m6lkrehi 667 4 the the DT cord-335975-m6lkrehi 667 5 first first JJ cord-335975-m6lkrehi 667 6 manifestation manifestation NN cord-335975-m6lkrehi 667 7 of of IN cord-335975-m6lkrehi 667 8 thyrotoxicosis thyrotoxicosis NN cord-335975-m6lkrehi 667 9 in in IN cord-335975-m6lkrehi 667 10 18 18 CD cord-335975-m6lkrehi 667 11 ( ( -LRB- cord-335975-m6lkrehi 667 12 29 29 CD cord-335975-m6lkrehi 667 13 % % NN cord-335975-m6lkrehi 667 14 ) ) -RRB- cord-335975-m6lkrehi 667 15 patients patient NNS cord-335975-m6lkrehi 667 16 . . . cord-335975-m6lkrehi 668 1 Graves grave NNS cord-335975-m6lkrehi 668 2 ' ' POS cord-335975-m6lkrehi 668 3 disease disease NN cord-335975-m6lkrehi 668 4 ( ( -LRB- cord-335975-m6lkrehi 668 5 27 27 CD cord-335975-m6lkrehi 668 6 % % NN cord-335975-m6lkrehi 668 7 ) ) -RRB- cord-335975-m6lkrehi 668 8 , , , cord-335975-m6lkrehi 668 9 amiodarone amiodarone NN cord-335975-m6lkrehi 668 10 induced induce VBN cord-335975-m6lkrehi 668 11 thyroiditis thyroiditis NN cord-335975-m6lkrehi 668 12 ( ( -LRB- cord-335975-m6lkrehi 668 13 26 26 CD cord-335975-m6lkrehi 668 14 % % NN cord-335975-m6lkrehi 668 15 ) ) -RRB- cord-335975-m6lkrehi 668 16 , , , cord-335975-m6lkrehi 668 17 autoimmune autoimmune JJ cord-335975-m6lkrehi 668 18 thyroiditis thyroiditis NN cord-335975-m6lkrehi 668 19 ( ( -LRB- cord-335975-m6lkrehi 668 20 11 11 CD cord-335975-m6lkrehi 668 21 % % NN cord-335975-m6lkrehi 668 22 ) ) -RRB- cord-335975-m6lkrehi 668 23 , , , cord-335975-m6lkrehi 668 24 and and CC cord-335975-m6lkrehi 668 25 toxic toxic JJ cord-335975-m6lkrehi 668 26 multinodular multinodular JJ cord-335975-m6lkrehi 668 27 goitre goitre NN cord-335975-m6lkrehi 668 28 ( ( -LRB- cord-335975-m6lkrehi 668 29 10 10 CD cord-335975-m6lkrehi 668 30 % % NN cord-335975-m6lkrehi 668 31 ) ) -RRB- cord-335975-m6lkrehi 668 32 were be VBD cord-335975-m6lkrehi 668 33 the the DT cord-335975-m6lkrehi 668 34 main main JJ cord-335975-m6lkrehi 668 35 causes cause NNS cord-335975-m6lkrehi 668 36 of of IN cord-335975-m6lkrehi 668 37 hyperthyroidism hyperthyroidism NN cord-335975-m6lkrehi 668 38 . . . cord-335975-m6lkrehi 669 1 Amiodarone Amiodarone NNP cord-335975-m6lkrehi 669 2 , , , cord-335975-m6lkrehi 669 3 thyroid thyroid JJ cord-335975-m6lkrehi 669 4 hormone hormone NN cord-335975-m6lkrehi 669 5 toxicity toxicity NN cord-335975-m6lkrehi 669 6 , , , cord-335975-m6lkrehi 669 7 antithyroid antithyroid NNP cord-335975-m6lkrehi 669 8 drugs drug NNS cord-335975-m6lkrehi 669 9 withdrawal withdrawal NN cord-335975-m6lkrehi 669 10 or or CC cord-335975-m6lkrehi 669 11 infectious infectious JJ cord-335975-m6lkrehi 669 12 trigger trigger NN cord-335975-m6lkrehi 669 13 were be VBD cord-335975-m6lkrehi 669 14 identified identify VBN cord-335975-m6lkrehi 669 15 in in IN cord-335975-m6lkrehi 669 16 59 59 CD cord-335975-m6lkrehi 669 17 ( ( -LRB- cord-335975-m6lkrehi 669 18 95 95 CD cord-335975-m6lkrehi 669 19 % % NN cord-335975-m6lkrehi 669 20 ) ) -RRB- cord-335975-m6lkrehi 669 21 patients patient NNS cord-335975-m6lkrehi 669 22 . . . cord-335975-m6lkrehi 670 1 Organ organ NN cord-335975-m6lkrehi 670 2 support support NN cord-335975-m6lkrehi 670 3 including include VBG cord-335975-m6lkrehi 670 4 mechanical mechanical JJ cord-335975-m6lkrehi 670 5 ventilation ventilation NN cord-335975-m6lkrehi 670 6 , , , cord-335975-m6lkrehi 670 7 catecholamine catecholamine NN cord-335975-m6lkrehi 670 8 infusion infusion NN cord-335975-m6lkrehi 670 9 , , , cord-335975-m6lkrehi 670 10 renal renal JJ cord-335975-m6lkrehi 670 11 replacement replacement NN cord-335975-m6lkrehi 670 12 therapy therapy NN cord-335975-m6lkrehi 670 13 and and CC cord-335975-m6lkrehi 670 14 veno veno NNP cord-335975-m6lkrehi 670 15 - - HYPH cord-335975-m6lkrehi 670 16 arterial arterial JJ cord-335975-m6lkrehi 670 17 ECMO ECMO NNP cord-335975-m6lkrehi 670 18 were be VBD cord-335975-m6lkrehi 670 19 used use VBN cord-335975-m6lkrehi 670 20 in in IN cord-335975-m6lkrehi 670 21 34 34 CD cord-335975-m6lkrehi 670 22 , , , cord-335975-m6lkrehi 670 23 31 31 CD cord-335975-m6lkrehi 670 24 , , , cord-335975-m6lkrehi 670 25 11 11 CD cord-335975-m6lkrehi 670 26 , , , cord-335975-m6lkrehi 670 27 and and CC cord-335975-m6lkrehi 670 28 12 12 CD cord-335975-m6lkrehi 670 29 patients patient NNS cord-335975-m6lkrehi 670 30 , , , cord-335975-m6lkrehi 670 31 respectively respectively RB cord-335975-m6lkrehi 670 32 . . . cord-335975-m6lkrehi 671 1 Main main JJ cord-335975-m6lkrehi 671 2 thyroid thyroid NN cord-335975-m6lkrehi 671 3 storm storm NN cord-335975-m6lkrehi 671 4 treatments treatment NNS cord-335975-m6lkrehi 671 5 included include VBD cord-335975-m6lkrehi 671 6 antithyroid antithyroid NNP cord-335975-m6lkrehi 671 7 drugs drug NNS cord-335975-m6lkrehi 671 8 ( ( -LRB- cord-335975-m6lkrehi 671 9 81 81 CD cord-335975-m6lkrehi 671 10 % % NN cord-335975-m6lkrehi 671 11 ) ) -RRB- cord-335975-m6lkrehi 671 12 , , , cord-335975-m6lkrehi 671 13 betablockers betablocker NNS cord-335975-m6lkrehi 671 14 ( ( -LRB- cord-335975-m6lkrehi 671 15 69 69 CD cord-335975-m6lkrehi 671 16 % % NN cord-335975-m6lkrehi 671 17 ) ) -RRB- cord-335975-m6lkrehi 671 18 , , , cord-335975-m6lkrehi 671 19 corticosteroids corticosteroid NNS cord-335975-m6lkrehi 671 20 ( ( -LRB- cord-335975-m6lkrehi 671 21 45 45 CD cord-335975-m6lkrehi 671 22 % % NN cord-335975-m6lkrehi 671 23 ) ) -RRB- cord-335975-m6lkrehi 671 24 , , , cord-335975-m6lkrehi 671 25 and and CC cord-335975-m6lkrehi 671 26 plasmapheresis plasmapheresis NN cord-335975-m6lkrehi 671 27 ( ( -LRB- cord-335975-m6lkrehi 671 28 13 13 CD cord-335975-m6lkrehi 671 29 % % NN cord-335975-m6lkrehi 671 30 ) ) -RRB- cord-335975-m6lkrehi 671 31 . . . cord-335975-m6lkrehi 672 1 Lastly lastly RB cord-335975-m6lkrehi 672 2 , , , cord-335975-m6lkrehi 672 3 ICUmortality ICUmortality NNP cord-335975-m6lkrehi 672 4 was be VBD cord-335975-m6lkrehi 672 5 16 16 CD cord-335975-m6lkrehi 672 6 % % NN cord-335975-m6lkrehi 672 7 , , , cord-335975-m6lkrehi 672 8 with with IN cord-335975-m6lkrehi 672 9 multiple multiple JJ cord-335975-m6lkrehi 672 10 organ organ NN cord-335975-m6lkrehi 672 11 failure failure NN cord-335975-m6lkrehi 672 12 responsible responsible JJ cord-335975-m6lkrehi 672 13 of of IN cord-335975-m6lkrehi 672 14 death death NN cord-335975-m6lkrehi 672 15 in in IN cord-335975-m6lkrehi 672 16 all all DT cord-335975-m6lkrehi 672 17 patients patient NNS cord-335975-m6lkrehi 672 18 . . . cord-335975-m6lkrehi 673 1 Although although IN cord-335975-m6lkrehi 673 2 its -PRON- PRP$ cord-335975-m6lkrehi 673 3 incidence incidence NN cord-335975-m6lkrehi 673 4 appears appear VBZ cord-335975-m6lkrehi 673 5 low low JJ cord-335975-m6lkrehi 673 6 , , , cord-335975-m6lkrehi 673 7 ICU ICU NNP cord-335975-m6lkrehi 673 8 physicians physician NNS cord-335975-m6lkrehi 673 9 should should MD cord-335975-m6lkrehi 673 10 be be VB cord-335975-m6lkrehi 673 11 aware aware JJ cord-335975-m6lkrehi 673 12 of of IN cord-335975-m6lkrehi 673 13 the the DT cord-335975-m6lkrehi 673 14 multiple multiple JJ cord-335975-m6lkrehi 673 15 clinical clinical JJ cord-335975-m6lkrehi 673 16 features feature NNS cord-335975-m6lkrehi 673 17 of of IN cord-335975-m6lkrehi 673 18 thyroid thyroid NN cord-335975-m6lkrehi 673 19 storm storm NN cord-335975-m6lkrehi 673 20 . . . cord-335975-m6lkrehi 674 1 Our -PRON- PRP$ cord-335975-m6lkrehi 674 2 preliminary preliminary JJ cord-335975-m6lkrehi 674 3 data datum NNS cord-335975-m6lkrehi 674 4 reported report VBD cord-335975-m6lkrehi 674 5 various various JJ cord-335975-m6lkrehi 674 6 specific specific JJ cord-335975-m6lkrehi 674 7 therapeutic therapeutic JJ cord-335975-m6lkrehi 674 8 management management NN cord-335975-m6lkrehi 674 9 of of IN cord-335975-m6lkrehi 674 10 this this DT cord-335975-m6lkrehi 674 11 potentially potentially RB cord-335975-m6lkrehi 674 12 fatal fatal JJ cord-335975-m6lkrehi 674 13 disease disease NN cord-335975-m6lkrehi 674 14 . . . cord-335975-m6lkrehi 675 1 Prompt prompt JJ cord-335975-m6lkrehi 675 2 initiation initiation NN cord-335975-m6lkrehi 675 3 of of IN cord-335975-m6lkrehi 675 4 targeted target VBN cord-335975-m6lkrehi 675 5 therapies therapy NNS cord-335975-m6lkrehi 675 6 is be VBZ cord-335975-m6lkrehi 675 7 required require VBN cord-335975-m6lkrehi 675 8 for for IN cord-335975-m6lkrehi 675 9 atypical atypical JJ cord-335975-m6lkrehi 675 10 hemolytic hemolytic JJ cord-335975-m6lkrehi 675 11 uremic uremic JJ cord-335975-m6lkrehi 675 12 syndrome syndrome NN cord-335975-m6lkrehi 675 13 ( ( -LRB- cord-335975-m6lkrehi 675 14 aHUS aHUS NNP cord-335975-m6lkrehi 675 15 ) ) -RRB- cord-335975-m6lkrehi 675 16 and and CC cord-335975-m6lkrehi 675 17 thrombotic thrombotic JJ cord-335975-m6lkrehi 675 18 thrombocytopenic thrombocytopenic JJ cord-335975-m6lkrehi 675 19 purpura purpura NN cord-335975-m6lkrehi 675 20 ( ( -LRB- cord-335975-m6lkrehi 675 21 TTP TTP NNP cord-335975-m6lkrehi 675 22 ) ) -RRB- cord-335975-m6lkrehi 675 23 , , , cord-335975-m6lkrehi 675 24 but but CC cord-335975-m6lkrehi 675 25 no no DT cord-335975-m6lkrehi 675 26 specific specific JJ cord-335975-m6lkrehi 675 27 therapy therapy NN cord-335975-m6lkrehi 675 28 is be VBZ cord-335975-m6lkrehi 675 29 consensual consensual JJ cord-335975-m6lkrehi 675 30 for for IN cord-335975-m6lkrehi 675 31 Shiga Shiga NNP cord-335975-m6lkrehi 675 32 toxinassociated toxinassociated JJ cord-335975-m6lkrehi 675 33 hemolytic hemolytic JJ cord-335975-m6lkrehi 675 34 uremic uremic JJ cord-335975-m6lkrehi 675 35 syndrome syndrome NN cord-335975-m6lkrehi 675 36 ( ( -LRB- cord-335975-m6lkrehi 675 37 STEC STEC NNP cord-335975-m6lkrehi 675 38 - - HYPH cord-335975-m6lkrehi 675 39 HUS HUS NNP cord-335975-m6lkrehi 675 40 ) ) -RRB- cord-335975-m6lkrehi 675 41 . . . cord-335975-m6lkrehi 676 1 Thus thus RB cord-335975-m6lkrehi 676 2 , , , cord-335975-m6lkrehi 676 3 rapid rapid JJ cord-335975-m6lkrehi 676 4 differentiation differentiation NN cord-335975-m6lkrehi 676 5 of of IN cord-335975-m6lkrehi 676 6 STEC STEC NNP cord-335975-m6lkrehi 676 7 - - HYPH cord-335975-m6lkrehi 676 8 HUS HUS NNP cord-335975-m6lkrehi 676 9 is be VBZ cord-335975-m6lkrehi 676 10 mandatory mandatory JJ cord-335975-m6lkrehi 676 11 to to TO cord-335975-m6lkrehi 676 12 tailor tailor VB cord-335975-m6lkrehi 676 13 the the DT cord-335975-m6lkrehi 676 14 initial initial JJ cord-335975-m6lkrehi 676 15 treatment treatment NN cord-335975-m6lkrehi 676 16 . . . cord-335975-m6lkrehi 677 1 Furthermore furthermore RB cord-335975-m6lkrehi 677 2 , , , cord-335975-m6lkrehi 677 3 apart apart RB cord-335975-m6lkrehi 677 4 from from IN cord-335975-m6lkrehi 677 5 large large JJ cord-335975-m6lkrehi 677 6 outbreaks outbreak NNS cord-335975-m6lkrehi 677 7 , , , cord-335975-m6lkrehi 677 8 characteristic characteristic JJ cord-335975-m6lkrehi 677 9 features feature NNS cord-335975-m6lkrehi 677 10 of of IN cord-335975-m6lkrehi 677 11 this this DT cord-335975-m6lkrehi 677 12 syndrome syndrome NN cord-335975-m6lkrehi 677 13 in in IN cord-335975-m6lkrehi 677 14 adults adult NNS cord-335975-m6lkrehi 677 15 have have VBP cord-335975-m6lkrehi 677 16 not not RB cord-335975-m6lkrehi 677 17 been be VBN cord-335975-m6lkrehi 677 18 described describe VBN cord-335975-m6lkrehi 677 19 . . . cord-335975-m6lkrehi 678 1 In in IN cord-335975-m6lkrehi 678 2 this this DT cord-335975-m6lkrehi 678 3 study study NN cord-335975-m6lkrehi 678 4 , , , cord-335975-m6lkrehi 678 5 we -PRON- PRP cord-335975-m6lkrehi 678 6 retrospectively retrospectively RB cord-335975-m6lkrehi 678 7 compared compare VBD cord-335975-m6lkrehi 678 8 the the DT cord-335975-m6lkrehi 678 9 characteristics characteristic NNS cord-335975-m6lkrehi 678 10 of of IN cord-335975-m6lkrehi 678 11 STEC STEC NNP cord-335975-m6lkrehi 678 12 - - HYPH cord-335975-m6lkrehi 678 13 HUS HUS NNP cord-335975-m6lkrehi 678 14 , , , cord-335975-m6lkrehi 678 15 aHUS ahus NN cord-335975-m6lkrehi 678 16 and and CC cord-335975-m6lkrehi 678 17 TTP TTP NNP cord-335975-m6lkrehi 678 18 patients patient NNS cord-335975-m6lkrehi 678 19 at at IN cord-335975-m6lkrehi 678 20 admission admission NN cord-335975-m6lkrehi 678 21 in in IN cord-335975-m6lkrehi 678 22 two two CD cord-335975-m6lkrehi 678 23 expert expert NN cord-335975-m6lkrehi 678 24 ICUs ICUs NNP cord-335975-m6lkrehi 678 25 . . . cord-335975-m6lkrehi 679 1 Patient Patient NNP cord-335975-m6lkrehi 679 2 were be VBD cord-335975-m6lkrehi 679 3 included include VBN cord-335975-m6lkrehi 679 4 if if IN cord-335975-m6lkrehi 679 5 they -PRON- PRP cord-335975-m6lkrehi 679 6 presented present VBD cord-335975-m6lkrehi 679 7 with with IN cord-335975-m6lkrehi 679 8 the the DT cord-335975-m6lkrehi 679 9 triad triad NNP cord-335975-m6lkrehi 679 10 of of IN cord-335975-m6lkrehi 679 11 mechanical mechanical JJ cord-335975-m6lkrehi 679 12 hemolytic hemolytic JJ cord-335975-m6lkrehi 679 13 anemia anemia NN cord-335975-m6lkrehi 679 14 , , , cord-335975-m6lkrehi 679 15 thrombocytopenia thrombocytopenia NN cord-335975-m6lkrehi 679 16 and and CC cord-335975-m6lkrehi 679 17 organ organ NN cord-335975-m6lkrehi 679 18 damage damage NN cord-335975-m6lkrehi 679 19 , , , cord-335975-m6lkrehi 679 20 and and CC cord-335975-m6lkrehi 679 21 TMAs TMAs NNP cord-335975-m6lkrehi 679 22 were be VBD cord-335975-m6lkrehi 679 23 classified classify VBN cord-335975-m6lkrehi 679 24 using use VBG cord-335975-m6lkrehi 679 25 international international JJ cord-335975-m6lkrehi 679 26 criteria criterion NNS cord-335975-m6lkrehi 679 27 . . . cord-335975-m6lkrehi 680 1 Other other JJ cord-335975-m6lkrehi 680 2 causes cause NNS cord-335975-m6lkrehi 680 3 than than IN cord-335975-m6lkrehi 680 4 STEC STEC NNP cord-335975-m6lkrehi 680 5 - - HYPH cord-335975-m6lkrehi 680 6 HUS HUS NNP cord-335975-m6lkrehi 680 7 , , , cord-335975-m6lkrehi 680 8 aHUS ahus NN cord-335975-m6lkrehi 680 9 and and CC cord-335975-m6lkrehi 680 10 TTP TTP NNP cord-335975-m6lkrehi 680 11 were be VBD cord-335975-m6lkrehi 680 12 excluded exclude VBN cord-335975-m6lkrehi 680 13 . . . cord-335975-m6lkrehi 681 1 Results result NNS cord-335975-m6lkrehi 681 2 : : : cord-335975-m6lkrehi 682 1 Amongst amongst IN cord-335975-m6lkrehi 682 2 236 236 CD cord-335975-m6lkrehi 682 3 TMAs tma NNS cord-335975-m6lkrehi 682 4 admitted admit VBN cord-335975-m6lkrehi 682 5 between between IN cord-335975-m6lkrehi 682 6 September September NNP cord-335975-m6lkrehi 682 7 2003 2003 CD cord-335975-m6lkrehi 682 8 and and CC cord-335975-m6lkrehi 682 9 January January NNP cord-335975-m6lkrehi 682 10 2017 2017 CD cord-335975-m6lkrehi 682 11 , , , cord-335975-m6lkrehi 682 12 12 12 CD cord-335975-m6lkrehi 682 13 STEC STEC NNP cord-335975-m6lkrehi 682 14 - - HYPH cord-335975-m6lkrehi 682 15 HUS HUS NNP cord-335975-m6lkrehi 682 16 , , , cord-335975-m6lkrehi 682 17 21 21 CD cord-335975-m6lkrehi 682 18 aHUS ahus JJ cord-335975-m6lkrehi 682 19 and and CC cord-335975-m6lkrehi 682 20 91 91 CD cord-335975-m6lkrehi 682 21 TTP TTP NNP cord-335975-m6lkrehi 682 22 were be VBD cord-335975-m6lkrehi 682 23 included include VBN cord-335975-m6lkrehi 682 24 . . . cord-335975-m6lkrehi 683 1 STEC STEC NNP cord-335975-m6lkrehi 683 2 - - HYPH cord-335975-m6lkrehi 683 3 HUS HUS NNP cord-335975-m6lkrehi 683 4 patients patient NNS cord-335975-m6lkrehi 683 5 were be VBD cord-335975-m6lkrehi 683 6 older old JJR cord-335975-m6lkrehi 683 7 ( ( -LRB- cord-335975-m6lkrehi 683 8 64 64 CD cord-335975-m6lkrehi 683 9 ) ) -RRB- cord-335975-m6lkrehi 683 10 than than IN cord-335975-m6lkrehi 683 11 aHUS ahus DT cord-335975-m6lkrehi 684 1 ( ( -LRB- cord-335975-m6lkrehi 684 2 36 36 CD cord-335975-m6lkrehi 684 3 , , , cord-335975-m6lkrehi 684 4 p p NN cord-335975-m6lkrehi 684 5 = = SYM cord-335975-m6lkrehi 684 6 0.02 0.02 CD cord-335975-m6lkrehi 684 7 ) ) -RRB- cord-335975-m6lkrehi 684 8 and and CC cord-335975-m6lkrehi 684 9 TTP TTP NNP cord-335975-m6lkrehi 684 10 patients patient NNS cord-335975-m6lkrehi 684 11 ( ( -LRB- cord-335975-m6lkrehi 684 12 43 43 CD cord-335975-m6lkrehi 684 13 , , , cord-335975-m6lkrehi 684 14 p p NN cord-335975-m6lkrehi 684 15 < < XX cord-335975-m6lkrehi 684 16 0.01 0.01 CD cord-335975-m6lkrehi 684 17 ) ) -RRB- cord-335975-m6lkrehi 684 18 . . . cord-335975-m6lkrehi 685 1 They -PRON- PRP cord-335975-m6lkrehi 685 2 presented present VBD cord-335975-m6lkrehi 685 3 with with IN cord-335975-m6lkrehi 685 4 more more RBR cord-335975-m6lkrehi 685 5 frequent frequent JJ cord-335975-m6lkrehi 685 6 digestive digestive JJ cord-335975-m6lkrehi 685 7 symptoms symptom NNS cord-335975-m6lkrehi 685 8 ( ( -LRB- cord-335975-m6lkrehi 685 9 92 92 CD cord-335975-m6lkrehi 685 10 versus versus IN cord-335975-m6lkrehi 685 11 62 62 CD cord-335975-m6lkrehi 685 12 and and CC cord-335975-m6lkrehi 685 13 37 37 CD cord-335975-m6lkrehi 685 14 % % NN cord-335975-m6lkrehi 685 15 for for IN cord-335975-m6lkrehi 685 16 aHUS ahus DT cord-335975-m6lkrehi 686 1 and and CC cord-335975-m6lkrehi 686 2 TTP TTP NNP cord-335975-m6lkrehi 686 3 , , , cord-335975-m6lkrehi 686 4 p p NN cord-335975-m6lkrehi 686 5 = = SYM cord-335975-m6lkrehi 686 6 0.01 0.01 CD cord-335975-m6lkrehi 686 7 and and CC cord-335975-m6lkrehi 686 8 < < NNP cord-335975-m6lkrehi 686 9 0.01 0.01 CD cord-335975-m6lkrehi 686 10 ) ) -RRB- cord-335975-m6lkrehi 686 11 , , , cord-335975-m6lkrehi 686 12 but but CC cord-335975-m6lkrehi 686 13 bloody bloody JJ cord-335975-m6lkrehi 686 14 diarrhea diarrhea NN cord-335975-m6lkrehi 686 15 was be VBD cord-335975-m6lkrehi 686 16 rare rare JJ cord-335975-m6lkrehi 686 17 ( ( -LRB- cord-335975-m6lkrehi 686 18 17 17 CD cord-335975-m6lkrehi 686 19 % % NN cord-335975-m6lkrehi 686 20 ) ) -RRB- cord-335975-m6lkrehi 686 21 and and CC cord-335975-m6lkrehi 686 22 non non JJ cord-335975-m6lkrehi 686 23 - - JJ cord-335975-m6lkrehi 686 24 statistically statistically RB cord-335975-m6lkrehi 686 25 different different JJ cord-335975-m6lkrehi 686 26 from from IN cord-335975-m6lkrehi 686 27 other other JJ cord-335975-m6lkrehi 686 28 TMAs tma NNS cord-335975-m6lkrehi 686 29 . . . cord-335975-m6lkrehi 687 1 Confusion confusion NN cord-335975-m6lkrehi 687 2 was be VBD cord-335975-m6lkrehi 687 3 more more RBR cord-335975-m6lkrehi 687 4 frequent frequent JJ cord-335975-m6lkrehi 687 5 in in IN cord-335975-m6lkrehi 687 6 STEC STEC NNP cord-335975-m6lkrehi 687 7 - - HYPH cord-335975-m6lkrehi 687 8 HUS HUS NNP cord-335975-m6lkrehi 687 9 ( ( -LRB- cord-335975-m6lkrehi 687 10 33 33 CD cord-335975-m6lkrehi 687 11 % % NN cord-335975-m6lkrehi 687 12 ) ) -RRB- cord-335975-m6lkrehi 687 13 than than IN cord-335975-m6lkrehi 687 14 aHUS ahus DT cord-335975-m6lkrehi 687 15 patients patient NNS cord-335975-m6lkrehi 687 16 ( ( -LRB- cord-335975-m6lkrehi 687 17 5 5 CD cord-335975-m6lkrehi 687 18 % % NN cord-335975-m6lkrehi 687 19 , , , cord-335975-m6lkrehi 687 20 p p NN cord-335975-m6lkrehi 687 21 = = SYM cord-335975-m6lkrehi 687 22 0.05 0.05 CD cord-335975-m6lkrehi 687 23 ) ) -RRB- cord-335975-m6lkrehi 687 24 . . . cord-335975-m6lkrehi 688 1 Biologically biologically RB cord-335975-m6lkrehi 688 2 , , , cord-335975-m6lkrehi 688 3 STEC STEC NNP cord-335975-m6lkrehi 688 4 - - HYPH cord-335975-m6lkrehi 688 5 HUS HUS NNP cord-335975-m6lkrehi 688 6 patients patient NNS cord-335975-m6lkrehi 688 7 displayed display VBD cord-335975-m6lkrehi 688 8 elevated elevated JJ cord-335975-m6lkrehi 688 9 fibrinogen fibrinogen NN cord-335975-m6lkrehi 688 10 levels level NNS cord-335975-m6lkrehi 688 11 ( ( -LRB- cord-335975-m6lkrehi 688 12 5.1 5.1 CD cord-335975-m6lkrehi 688 13 vs vs IN cord-335975-m6lkrehi 688 14 3.2 3.2 CD cord-335975-m6lkrehi 688 15 and and CC cord-335975-m6lkrehi 688 16 3.6 3.6 CD cord-335975-m6lkrehi 688 17 for for IN cord-335975-m6lkrehi 688 18 a a DT cord-335975-m6lkrehi 688 19 HUS HUS NNP cord-335975-m6lkrehi 688 20 and and CC cord-335975-m6lkrehi 688 21 TTP ttp NN cord-335975-m6lkrehi 688 22 , , , cord-335975-m6lkrehi 688 23 both both DT cord-335975-m6lkrehi 688 24 p p NN cord-335975-m6lkrehi 688 25 < < XX cord-335975-m6lkrehi 688 26 0.01 0.01 CD cord-335975-m6lkrehi 688 27 ) ) -RRB- cord-335975-m6lkrehi 688 28 and and CC cord-335975-m6lkrehi 688 29 severe severe JJ cord-335975-m6lkrehi 688 30 renal renal JJ cord-335975-m6lkrehi 688 31 failure failure NN cord-335975-m6lkrehi 688 32 . . . cord-335975-m6lkrehi 689 1 Forty forty CD cord-335975-m6lkrehi 689 2 - - HYPH cord-335975-m6lkrehi 689 3 two two CD cord-335975-m6lkrehi 689 4 percent percent NN cord-335975-m6lkrehi 689 5 required require VBD cord-335975-m6lkrehi 689 6 renal renal JJ cord-335975-m6lkrehi 689 7 replacement replacement NN cord-335975-m6lkrehi 689 8 therapy therapy NN cord-335975-m6lkrehi 689 9 and and CC cord-335975-m6lkrehi 689 10 83 83 CD cord-335975-m6lkrehi 689 11 % % NN cord-335975-m6lkrehi 689 12 were be VBD cord-335975-m6lkrehi 689 13 treated treat VBN cord-335975-m6lkrehi 689 14 with with IN cord-335975-m6lkrehi 689 15 plasma plasma NN cord-335975-m6lkrehi 689 16 exchange exchange NN cord-335975-m6lkrehi 689 17 before before IN cord-335975-m6lkrehi 689 18 the the DT cord-335975-m6lkrehi 689 19 distinction distinction NN cord-335975-m6lkrehi 689 20 from from IN cord-335975-m6lkrehi 689 21 other other JJ cord-335975-m6lkrehi 689 22 TMAs tma NNS cord-335975-m6lkrehi 689 23 could could MD cord-335975-m6lkrehi 689 24 be be VB cord-335975-m6lkrehi 689 25 made make VBN cord-335975-m6lkrehi 689 26 . . . cord-335975-m6lkrehi 690 1 Only only RB cord-335975-m6lkrehi 690 2 1 1 CD cord-335975-m6lkrehi 690 3 ( ( -LRB- cord-335975-m6lkrehi 690 4 8 8 CD cord-335975-m6lkrehi 690 5 % % NN cord-335975-m6lkrehi 690 6 ) ) -RRB- cord-335975-m6lkrehi 690 7 STEC STEC NNP cord-335975-m6lkrehi 690 8 - - HYPH cord-335975-m6lkrehi 690 9 HUS HUS NNP cord-335975-m6lkrehi 690 10 patient patient NN cord-335975-m6lkrehi 690 11 died die VBD cord-335975-m6lkrehi 690 12 in in IN cord-335975-m6lkrehi 690 13 the the DT cord-335975-m6lkrehi 690 14 ICU ICU NNP cord-335975-m6lkrehi 690 15 ( ( -LRB- cord-335975-m6lkrehi 690 16 Fig Fig NNP cord-335975-m6lkrehi 690 17 . . NNP cord-335975-m6lkrehi 690 18 1 1 CD cord-335975-m6lkrehi 690 19 ) ) -RRB- cord-335975-m6lkrehi 690 20 . . . cord-335975-m6lkrehi 691 1 Conclusion conclusion NN cord-335975-m6lkrehi 691 2 : : : cord-335975-m6lkrehi 692 1 Characteristics characteristic NNS cord-335975-m6lkrehi 692 2 supposed suppose VBD cord-335975-m6lkrehi 692 3 to to TO cord-335975-m6lkrehi 692 4 identify identify VB cord-335975-m6lkrehi 692 5 STEC STEC NNP cord-335975-m6lkrehi 692 6 - - HYPH cord-335975-m6lkrehi 692 7 HUS HUS NNP cord-335975-m6lkrehi 692 8 are be VBP cord-335975-m6lkrehi 692 9 largely largely RB cord-335975-m6lkrehi 692 10 shared share VBN cord-335975-m6lkrehi 692 11 with with IN cord-335975-m6lkrehi 692 12 other other JJ cord-335975-m6lkrehi 692 13 TMAs tma NNS cord-335975-m6lkrehi 692 14 . . . cord-335975-m6lkrehi 693 1 In in IN cord-335975-m6lkrehi 693 2 particular particular JJ cord-335975-m6lkrehi 693 3 , , , cord-335975-m6lkrehi 693 4 the the DT cord-335975-m6lkrehi 693 5 differential differential JJ cord-335975-m6lkrehi 693 6 diagnosis diagnosis NN cord-335975-m6lkrehi 693 7 between between IN cord-335975-m6lkrehi 693 8 aHUS ahus DT cord-335975-m6lkrehi 693 9 and and CC cord-335975-m6lkrehi 693 10 STEC STEC NNP cord-335975-m6lkrehi 693 11 - - HYPH cord-335975-m6lkrehi 693 12 HUS HUS NNP cord-335975-m6lkrehi 693 13 appears appear VBZ cord-335975-m6lkrehi 693 14 to to TO cord-335975-m6lkrehi 693 15 be be VB cord-335975-m6lkrehi 693 16 more more RBR cord-335975-m6lkrehi 693 17 difficult difficult JJ cord-335975-m6lkrehi 693 18 than than IN cord-335975-m6lkrehi 693 19 the the DT cord-335975-m6lkrehi 693 20 stereotypical stereotypical JJ cord-335975-m6lkrehi 693 21 description description NN cord-335975-m6lkrehi 693 22 derived derive VBN cord-335975-m6lkrehi 693 23 from from IN cord-335975-m6lkrehi 693 24 pediatric pediatric JJ cord-335975-m6lkrehi 693 25 studies study NNS cord-335975-m6lkrehi 693 26 . . . cord-335975-m6lkrehi 694 1 Severe severe JJ cord-335975-m6lkrehi 694 2 hyperglycemia hyperglycemia NN cord-335975-m6lkrehi 694 3 in in IN cord-335975-m6lkrehi 694 4 1000 1000 CD cord-335975-m6lkrehi 694 5 ICU ICU NNP cord-335975-m6lkrehi 694 6 patients patient NNS cord-335975-m6lkrehi 694 7 : : : cord-335975-m6lkrehi 694 8 a a DT cord-335975-m6lkrehi 694 9 higher high JJR cord-335975-m6lkrehi 694 10 mortality mortality NN cord-335975-m6lkrehi 694 11 rate rate NN cord-335975-m6lkrehi 694 12 and and CC cord-335975-m6lkrehi 694 13 a a DT cord-335975-m6lkrehi 694 14 higher high JJR cord-335975-m6lkrehi 694 15 incidence incidence NN cord-335975-m6lkrehi 694 16 of of IN cord-335975-m6lkrehi 694 17 diabetes diabetes NN cord-335975-m6lkrehi 694 18 in in IN cord-335975-m6lkrehi 694 19 a a DT cord-335975-m6lkrehi 694 20 long long JJ cord-335975-m6lkrehi 694 21 - - HYPH cord-335975-m6lkrehi 694 22 term term NN cord-335975-m6lkrehi 694 23 follow follow NN cord-335975-m6lkrehi 694 24 - - HYPH cord-335975-m6lkrehi 694 25 up up NN cord-335975-m6lkrehi 694 26 study study NN cord-335975-m6lkrehi 694 27 .87 .87 . cord-335975-m6lkrehi 694 28 ] ] -RRB- cord-335975-m6lkrehi 694 29 , , , cord-335975-m6lkrehi 694 30 p p NN cord-335975-m6lkrehi 694 31 = = SYM cord-335975-m6lkrehi 694 32 0.04 0.04 CD cord-335975-m6lkrehi 694 33 ) ) -RRB- cord-335975-m6lkrehi 695 1 but but CC cord-335975-m6lkrehi 695 2 not not RB cord-335975-m6lkrehi 695 3 when when WRB cord-335975-m6lkrehi 695 4 admitted admit VBN cord-335975-m6lkrehi 695 5 for for IN cord-335975-m6lkrehi 695 6 coma coma NN cord-335975-m6lkrehi 695 7 , , , cord-335975-m6lkrehi 695 8 sepsis sepsis NN cord-335975-m6lkrehi 695 9 or or CC cord-335975-m6lkrehi 695 10 cardiac cardiac JJ cord-335975-m6lkrehi 695 11 arrest arrest NN cord-335975-m6lkrehi 695 12 . . . cord-335975-m6lkrehi 696 1 Mortality mortality NN cord-335975-m6lkrehi 696 2 rate rate NN cord-335975-m6lkrehi 696 3 was be VBD cord-335975-m6lkrehi 696 4 significantly significantly RB cord-335975-m6lkrehi 696 5 higher high JJR cord-335975-m6lkrehi 696 6 in in IN cord-335975-m6lkrehi 696 7 patients patient NNS cord-335975-m6lkrehi 696 8 with with IN cord-335975-m6lkrehi 696 9 severe severe JJ cord-335975-m6lkrehi 696 10 hyperglycemia hyperglycemia NN cord-335975-m6lkrehi 696 11 compared compare VBN cord-335975-m6lkrehi 696 12 to to IN cord-335975-m6lkrehi 696 13 those those DT cord-335975-m6lkrehi 696 14 without without IN cord-335975-m6lkrehi 696 15 , , , cord-335975-m6lkrehi 696 16 regardless regardless RB cord-335975-m6lkrehi 696 17 of of IN cord-335975-m6lkrehi 696 18 preexisting preexist VBG cord-335975-m6lkrehi 696 19 diabetes diabete NNS cord-335975-m6lkrehi 696 20 ( ( -LRB- cord-335975-m6lkrehi 696 21 HND HND NNP cord-335975-m6lkrehi 696 22 HD HD NNP cord-335975-m6lkrehi 696 23 vs. vs. IN cord-335975-m6lkrehi 696 24 NHND NHND NNP cord-335975-m6lkrehi 696 25 NHD NHD NNP cord-335975-m6lkrehi 696 26 groups group NNS cord-335975-m6lkrehi 696 27 + + CC cord-335975-m6lkrehi 696 28 p p NN cord-335975-m6lkrehi 696 29 < < XX cord-335975-m6lkrehi 696 30 0.05 0.05 CD cord-335975-m6lkrehi 696 31 ) ) -RRB- cord-335975-m6lkrehi 696 32 . . . cord-335975-m6lkrehi 697 1 Patients patient NNS cord-335975-m6lkrehi 697 2 with with IN cord-335975-m6lkrehi 697 3 severe severe JJ cord-335975-m6lkrehi 697 4 hyperglycemia hyperglycemia NN cord-335975-m6lkrehi 697 5 had have VBD cord-335975-m6lkrehi 697 6 a a DT cord-335975-m6lkrehi 697 7 higher high JJR cord-335975-m6lkrehi 697 8 incidence incidence NN cord-335975-m6lkrehi 697 9 of of IN cord-335975-m6lkrehi 697 10 type type NN cord-335975-m6lkrehi 697 11 2 2 CD cord-335975-m6lkrehi 697 12 diabetes diabete NNS cord-335975-m6lkrehi 697 13 at at IN cord-335975-m6lkrehi 697 14 6 6 CD cord-335975-m6lkrehi 697 15 ( ( -LRB- cord-335975-m6lkrehi 697 16 16 16 CD cord-335975-m6lkrehi 697 17 vs. vs. NN cord-335975-m6lkrehi 697 18 8 8 CD cord-335975-m6lkrehi 697 19 % % NN cord-335975-m6lkrehi 697 20 + + CC cord-335975-m6lkrehi 698 1 p p NN cord-335975-m6lkrehi 698 2 = = SYM cord-335975-m6lkrehi 698 3 0.01 0.01 CD cord-335975-m6lkrehi 698 4 ) ) -RRB- cord-335975-m6lkrehi 698 5 and and CC cord-335975-m6lkrehi 698 6 12 12 CD cord-335975-m6lkrehi 698 7 months month NNS cord-335975-m6lkrehi 698 8 ( ( -LRB- cord-335975-m6lkrehi 698 9 14 14 CD cord-335975-m6lkrehi 698 10 vs. vs. IN cord-335975-m6lkrehi 698 11 9 9 CD cord-335975-m6lkrehi 698 12 % % NN cord-335975-m6lkrehi 699 1 + + CC cord-335975-m6lkrehi 700 1 p p NN cord-335975-m6lkrehi 700 2 = = SYM cord-335975-m6lkrehi 700 3 0.08 0.08 CD cord-335975-m6lkrehi 700 4 ) ) -RRB- cord-335975-m6lkrehi 701 1 compared compare VBN cord-335975-m6lkrehi 701 2 to to IN cord-335975-m6lkrehi 701 3 those those DT cord-335975-m6lkrehi 701 4 who who WP cord-335975-m6lkrehi 701 5 did do VBD cord-335975-m6lkrehi 701 6 not not RB cord-335975-m6lkrehi 701 7 . . . cord-335975-m6lkrehi 702 1 Conclusion conclusion NN cord-335975-m6lkrehi 702 2 : : : cord-335975-m6lkrehi 703 1 Severe severe JJ cord-335975-m6lkrehi 703 2 hyperglycemia hyperglycemia NN cord-335975-m6lkrehi 703 3 occurring occur VBG cord-335975-m6lkrehi 703 4 in in IN cord-335975-m6lkrehi 703 5 the the DT cord-335975-m6lkrehi 703 6 first first JJ cord-335975-m6lkrehi 703 7 3 3 CD cord-335975-m6lkrehi 703 8 days day NNS cord-335975-m6lkrehi 703 9 of of IN cord-335975-m6lkrehi 703 10 ICU ICU NNP cord-335975-m6lkrehi 703 11 admission admission NN cord-335975-m6lkrehi 703 12 was be VBD cord-335975-m6lkrehi 703 13 associated associate VBN cord-335975-m6lkrehi 703 14 with with IN cord-335975-m6lkrehi 703 15 higher high JJR cord-335975-m6lkrehi 703 16 mortality mortality NN cord-335975-m6lkrehi 703 17 rate rate NN cord-335975-m6lkrehi 703 18 and and CC cord-335975-m6lkrehi 703 19 an an DT cord-335975-m6lkrehi 703 20 increased increase VBN cord-335975-m6lkrehi 703 21 risk risk NN cord-335975-m6lkrehi 703 22 of of IN cord-335975-m6lkrehi 703 23 diabetes diabete NNS cord-335975-m6lkrehi 703 24 in in IN cord-335975-m6lkrehi 703 25 the the DT cord-335975-m6lkrehi 703 26 following following JJ cord-335975-m6lkrehi 703 27 months month NNS cord-335975-m6lkrehi 703 28 regardless regardless RB cord-335975-m6lkrehi 703 29 of of IN cord-335975-m6lkrehi 703 30 preexisting preexist VBG cord-335975-m6lkrehi 703 31 diabetes diabete NNS cord-335975-m6lkrehi 703 32 . . . cord-335975-m6lkrehi 704 1 Introduction introduction NN cord-335975-m6lkrehi 704 2 : : : cord-335975-m6lkrehi 705 1 Vitamin vitamin NN cord-335975-m6lkrehi 705 2 D d NN cord-335975-m6lkrehi 705 3 deficiency deficiency NN cord-335975-m6lkrehi 705 4 is be VBZ cord-335975-m6lkrehi 705 5 frequent frequent JJ cord-335975-m6lkrehi 705 6 in in IN cord-335975-m6lkrehi 705 7 Northwestern northwestern JJ cord-335975-m6lkrehi 705 8 countries country NNS cord-335975-m6lkrehi 705 9 and and CC cord-335975-m6lkrehi 705 10 could could MD cord-335975-m6lkrehi 705 11 represent represent VB cord-335975-m6lkrehi 705 12 a a DT cord-335975-m6lkrehi 705 13 modifiable modifiable JJ cord-335975-m6lkrehi 705 14 risk risk NN cord-335975-m6lkrehi 705 15 factor factor NN cord-335975-m6lkrehi 705 16 for for IN cord-335975-m6lkrehi 705 17 critically critically RB cord-335975-m6lkrehi 705 18 ill ill JJ cord-335975-m6lkrehi 705 19 patients patient NNS cord-335975-m6lkrehi 705 20 , , , cord-335975-m6lkrehi 705 21 in in IN cord-335975-m6lkrehi 705 22 relation relation NN cord-335975-m6lkrehi 705 23 with with IN cord-335975-m6lkrehi 705 24 its -PRON- PRP$ cord-335975-m6lkrehi 705 25 pleiotropic pleiotropic JJ cord-335975-m6lkrehi 705 26 effects effect NNS cord-335975-m6lkrehi 705 27 ( ( -LRB- cord-335975-m6lkrehi 705 28 1 1 CD cord-335975-m6lkrehi 705 29 ) ) -RRB- cord-335975-m6lkrehi 705 30 . . . cord-335975-m6lkrehi 706 1 Some some DT cord-335975-m6lkrehi 706 2 studies study NNS cord-335975-m6lkrehi 706 3 reported report VBD cord-335975-m6lkrehi 706 4 an an DT cord-335975-m6lkrehi 706 5 association association NN cord-335975-m6lkrehi 706 6 between between IN cord-335975-m6lkrehi 706 7 25OH 25oh CD cord-335975-m6lkrehi 706 8 vitamin vitamin NN cord-335975-m6lkrehi 706 9 D d NN cord-335975-m6lkrehi 706 10 ( ( -LRB- cord-335975-m6lkrehi 706 11 25OH 25oh CD cord-335975-m6lkrehi 706 12 ) ) -RRB- cord-335975-m6lkrehi 706 13 deficiency deficiency NN cord-335975-m6lkrehi 706 14 , , , cord-335975-m6lkrehi 706 15 chronic chronic JJ cord-335975-m6lkrehi 706 16 health health NN cord-335975-m6lkrehi 706 17 status status NN cord-335975-m6lkrehi 706 18 and and CC cord-335975-m6lkrehi 706 19 ICU ICU NNP cord-335975-m6lkrehi 706 20 - - HYPH cord-335975-m6lkrehi 706 21 and and CC cord-335975-m6lkrehi 706 22 hospital hospital NN cord-335975-m6lkrehi 706 23 - - HYPH cord-335975-m6lkrehi 706 24 related relate VBN cord-335975-m6lkrehi 706 25 outcomes outcome NNS cord-335975-m6lkrehi 706 26 . . . cord-335975-m6lkrehi 707 1 However however RB cord-335975-m6lkrehi 707 2 , , , cord-335975-m6lkrehi 707 3 a a DT cord-335975-m6lkrehi 707 4 large large JJ cord-335975-m6lkrehi 707 5 supplementation supplementation NN cord-335975-m6lkrehi 707 6 study study NN cord-335975-m6lkrehi 707 7 have have VBP cord-335975-m6lkrehi 707 8 not not RB cord-335975-m6lkrehi 707 9 been be VBN cord-335975-m6lkrehi 707 10 found find VBN cord-335975-m6lkrehi 707 11 to to TO cord-335975-m6lkrehi 707 12 improve improve VB cord-335975-m6lkrehi 707 13 outcome outcome NN cord-335975-m6lkrehi 707 14 of of IN cord-335975-m6lkrehi 707 15 patients patient NNS cord-335975-m6lkrehi 707 16 with with IN cord-335975-m6lkrehi 707 17 moderate moderate JJ cord-335975-m6lkrehi 707 18 25OH 25oh CD cord-335975-m6lkrehi 707 19 deficiency deficiency NN cord-335975-m6lkrehi 707 20 ( ( -LRB- cord-335975-m6lkrehi 707 21 < < NNP cord-335975-m6lkrehi 707 22 20 20 CD cord-335975-m6lkrehi 707 23 ng ng NN cord-335975-m6lkrehi 707 24 ml ml NN cord-335975-m6lkrehi 707 25 ) ) -RRB- cord-335975-m6lkrehi 707 26 ( ( -LRB- cord-335975-m6lkrehi 707 27 2 2 CD cord-335975-m6lkrehi 707 28 ) ) -RRB- cord-335975-m6lkrehi 707 29 . . . cord-335975-m6lkrehi 708 1 The the DT cord-335975-m6lkrehi 708 2 aim aim NN cord-335975-m6lkrehi 708 3 of of IN cord-335975-m6lkrehi 708 4 the the DT cord-335975-m6lkrehi 708 5 study study NN cord-335975-m6lkrehi 708 6 is be VBZ cord-335975-m6lkrehi 708 7 to to TO cord-335975-m6lkrehi 708 8 analyze analyze VB cord-335975-m6lkrehi 708 9 the the DT cord-335975-m6lkrehi 708 10 relationship relationship NN cord-335975-m6lkrehi 708 11 between between IN cord-335975-m6lkrehi 708 12 the the DT cord-335975-m6lkrehi 708 13 severity severity NN cord-335975-m6lkrehi 708 14 of of IN cord-335975-m6lkrehi 708 15 25OH 25oh CD cord-335975-m6lkrehi 708 16 deficiency deficiency NN cord-335975-m6lkrehi 708 17 at at IN cord-335975-m6lkrehi 708 18 ICU ICU NNP cord-335975-m6lkrehi 708 19 admission admission NN cord-335975-m6lkrehi 708 20 , , , cord-335975-m6lkrehi 708 21 severity severity NN cord-335975-m6lkrehi 708 22 of of IN cord-335975-m6lkrehi 708 23 illness illness NN cord-335975-m6lkrehi 708 24 and and CC cord-335975-m6lkrehi 708 25 outcomes outcome NNS cord-335975-m6lkrehi 708 26 and and CC cord-335975-m6lkrehi 708 27 ultimately ultimately RB cord-335975-m6lkrehi 708 28 to to TO cord-335975-m6lkrehi 708 29 identify identify VB cord-335975-m6lkrehi 708 30 subgroups subgroup NNS cord-335975-m6lkrehi 708 31 of of IN cord-335975-m6lkrehi 708 32 patients patient NNS cord-335975-m6lkrehi 708 33 in in IN cord-335975-m6lkrehi 708 34 whom whom WP cord-335975-m6lkrehi 708 35 the the DT cord-335975-m6lkrehi 708 36 likelihood likelihood NN cord-335975-m6lkrehi 708 37 of of IN cord-335975-m6lkrehi 708 38 benefit benefit NN cord-335975-m6lkrehi 708 39 of of IN cord-335975-m6lkrehi 708 40 supplementation supplementation NN cord-335975-m6lkrehi 708 41 is be VBZ cord-335975-m6lkrehi 708 42 larger large JJR cord-335975-m6lkrehi 708 43 . . . cord-335975-m6lkrehi 709 1 Patients patient NNS cord-335975-m6lkrehi 709 2 and and CC cord-335975-m6lkrehi 709 3 methods method NNS cord-335975-m6lkrehi 709 4 : : : cord-335975-m6lkrehi 709 5 Consecutive consecutive JJ cord-335975-m6lkrehi 709 6 patients patient NNS cord-335975-m6lkrehi 709 7 admitted admit VBD cord-335975-m6lkrehi 709 8 over over IN cord-335975-m6lkrehi 709 9 a a DT cord-335975-m6lkrehi 709 10 4-month 4-month JJ cord-335975-m6lkrehi 709 11 period period NN cord-335975-m6lkrehi 709 12 who who WP cord-335975-m6lkrehi 709 13 stayed stay VBD cord-335975-m6lkrehi 709 14 at at IN cord-335975-m6lkrehi 709 15 least least JJS cord-335975-m6lkrehi 709 16 48 48 CD cord-335975-m6lkrehi 709 17 h h NN cord-335975-m6lkrehi 709 18 in in IN cord-335975-m6lkrehi 709 19 a a DT cord-335975-m6lkrehi 709 20 medical medical JJ cord-335975-m6lkrehi 709 21 surgical surgical JJ cord-335975-m6lkrehi 709 22 32-bed 32-bed CD cord-335975-m6lkrehi 709 23 ICU ICU NNP cord-335975-m6lkrehi 709 24 were be VBD cord-335975-m6lkrehi 709 25 included include VBN cord-335975-m6lkrehi 709 26 . . . cord-335975-m6lkrehi 710 1 In in IN cord-335975-m6lkrehi 710 2 these these DT cord-335975-m6lkrehi 710 3 patients patient NNS cord-335975-m6lkrehi 710 4 , , , cord-335975-m6lkrehi 710 5 demographic demographic JJ cord-335975-m6lkrehi 710 6 data datum NNS cord-335975-m6lkrehi 710 7 , , , cord-335975-m6lkrehi 710 8 Charlson Charlson NNP cord-335975-m6lkrehi 710 9 comorbidity comorbidity NN cord-335975-m6lkrehi 710 10 score score NN cord-335975-m6lkrehi 710 11 , , , cord-335975-m6lkrehi 710 12 severity severity NN cord-335975-m6lkrehi 710 13 scores score NNS cord-335975-m6lkrehi 710 14 ( ( -LRB- cord-335975-m6lkrehi 710 15 SAPS SAPS NNP cord-335975-m6lkrehi 710 16 3 3 CD cord-335975-m6lkrehi 710 17 and and CC cord-335975-m6lkrehi 710 18 SOFA SOFA NNP cord-335975-m6lkrehi 710 19 ) ) -RRB- cord-335975-m6lkrehi 710 20 and and CC cord-335975-m6lkrehi 710 21 25-OH 25-OH NNP cord-335975-m6lkrehi 710 22 ( ( -LRB- cord-335975-m6lkrehi 710 23 chemiluminescence chemiluminescence NN cord-335975-m6lkrehi 710 24 , , , cord-335975-m6lkrehi 710 25 DiaSorin DiaSorin NNP cord-335975-m6lkrehi 710 26 ) ) -RRB- cord-335975-m6lkrehi 710 27 were be VBD cord-335975-m6lkrehi 710 28 collected collect VBN cord-335975-m6lkrehi 710 29 at at IN cord-335975-m6lkrehi 710 30 admission admission NN cord-335975-m6lkrehi 710 31 . . . cord-335975-m6lkrehi 711 1 ICU ICU NNP cord-335975-m6lkrehi 711 2 and and CC cord-335975-m6lkrehi 711 3 hospital hospital NN cord-335975-m6lkrehi 711 4 length length NN cord-335975-m6lkrehi 711 5 of of IN cord-335975-m6lkrehi 711 6 stay stay NN cord-335975-m6lkrehi 711 7 ( ( -LRB- cord-335975-m6lkrehi 711 8 LOS LOS NNP cord-335975-m6lkrehi 711 9 ) ) -RRB- cord-335975-m6lkrehi 711 10 and and CC cord-335975-m6lkrehi 711 11 mortality mortality NN cord-335975-m6lkrehi 711 12 were be VBD cord-335975-m6lkrehi 711 13 recorded record VBN cord-335975-m6lkrehi 711 14 . . . cord-335975-m6lkrehi 712 1 Correlations correlation NNS cord-335975-m6lkrehi 712 2 were be VBD cord-335975-m6lkrehi 712 3 searched search VBN cord-335975-m6lkrehi 712 4 between between IN cord-335975-m6lkrehi 712 5 25OH 25oh CD cord-335975-m6lkrehi 712 6 and and CC cord-335975-m6lkrehi 712 7 the the DT cord-335975-m6lkrehi 712 8 different different JJ cord-335975-m6lkrehi 712 9 scores score NNS cord-335975-m6lkrehi 712 10 , , , cord-335975-m6lkrehi 712 11 and and CC cord-335975-m6lkrehi 712 12 vital vital JJ cord-335975-m6lkrehi 712 13 outcomes outcome NNS cord-335975-m6lkrehi 712 14 ( ( -LRB- cord-335975-m6lkrehi 712 15 41 41 CD cord-335975-m6lkrehi 712 16 - - SYM cord-335975-m6lkrehi 712 17 74 74 CD cord-335975-m6lkrehi 712 18 ) ) -RRB- cord-335975-m6lkrehi 712 19 ) ) -RRB- cord-335975-m6lkrehi 712 20 . . . cord-335975-m6lkrehi 713 1 Hypothyroidism hypothyroidism NN cord-335975-m6lkrehi 713 2 was be VBD cord-335975-m6lkrehi 713 3 unknown unknown JJ cord-335975-m6lkrehi 713 4 before before IN cord-335975-m6lkrehi 713 5 ICU ICU NNP cord-335975-m6lkrehi 713 6 admission admission NN cord-335975-m6lkrehi 713 7 in in IN cord-335975-m6lkrehi 713 8 68 68 CD cord-335975-m6lkrehi 713 9 % % NN cord-335975-m6lkrehi 713 10 patients patient NNS cord-335975-m6lkrehi 713 11 . . . cord-335975-m6lkrehi 714 1 Median median JJ cord-335975-m6lkrehi 714 2 SOFA sofa NN cord-335975-m6lkrehi 714 3 score score NN cord-335975-m6lkrehi 714 4 at at IN cord-335975-m6lkrehi 714 5 ICU ICU NNP cord-335975-m6lkrehi 714 6 admission admission NN cord-335975-m6lkrehi 714 7 was be VBD cord-335975-m6lkrehi 714 8 6 6 CD cord-335975-m6lkrehi 714 9 ( ( -LRB- cord-335975-m6lkrehi 714 10 4 4 CD cord-335975-m6lkrehi 714 11 - - SYM cord-335975-m6lkrehi 714 12 10 10 CD cord-335975-m6lkrehi 714 13 ) ) -RRB- cord-335975-m6lkrehi 714 14 . . . cord-335975-m6lkrehi 715 1 Myxedema Myxedema NNP cord-335975-m6lkrehi 715 2 coma coma NN cord-335975-m6lkrehi 715 3 , , , cord-335975-m6lkrehi 715 4 circulatory circulatory JJ cord-335975-m6lkrehi 715 5 failure failure NN cord-335975-m6lkrehi 715 6 , , , cord-335975-m6lkrehi 715 7 respiratory respiratory JJ cord-335975-m6lkrehi 715 8 failure failure NN cord-335975-m6lkrehi 715 9 , , , cord-335975-m6lkrehi 715 10 and and CC cord-335975-m6lkrehi 715 11 severe severe JJ cord-335975-m6lkrehi 715 12 hypothermia hypothermia NN cord-335975-m6lkrehi 715 13 were be VBD cord-335975-m6lkrehi 715 14 respectively respectively RB cord-335975-m6lkrehi 715 15 the the DT cord-335975-m6lkrehi 715 16 main main JJ cord-335975-m6lkrehi 715 17 admission admission NN cord-335975-m6lkrehi 715 18 reason reason NN cord-335975-m6lkrehi 715 19 in in IN cord-335975-m6lkrehi 715 20 60 60 CD cord-335975-m6lkrehi 715 21 , , , cord-335975-m6lkrehi 715 22 18 18 CD cord-335975-m6lkrehi 715 23 , , , cord-335975-m6lkrehi 715 24 10 10 CD cord-335975-m6lkrehi 715 25 , , , cord-335975-m6lkrehi 715 26 and and CC cord-335975-m6lkrehi 715 27 5 5 CD cord-335975-m6lkrehi 715 28 % % NN cord-335975-m6lkrehi 715 29 patients patient NNS cord-335975-m6lkrehi 715 30 . . . cord-335975-m6lkrehi 716 1 A a DT cord-335975-m6lkrehi 716 2 precipitating precipitate VBG cord-335975-m6lkrehi 716 3 factor factor NN cord-335975-m6lkrehi 716 4 such such JJ cord-335975-m6lkrehi 716 5 as as IN cord-335975-m6lkrehi 716 6 drugs drug NNS cord-335975-m6lkrehi 716 7 thyroid thyroid NN cord-335975-m6lkrehi 716 8 toxicity toxicity NN cord-335975-m6lkrehi 716 9 , , , cord-335975-m6lkrehi 716 10 thyroid thyroid NN cord-335975-m6lkrehi 716 11 hormone hormone NN cord-335975-m6lkrehi 716 12 withdrawal withdrawal NN cord-335975-m6lkrehi 716 13 or or CC cord-335975-m6lkrehi 716 14 infection infection NN cord-335975-m6lkrehi 716 15 was be VBD cord-335975-m6lkrehi 716 16 found find VBN cord-335975-m6lkrehi 716 17 out out RP cord-335975-m6lkrehi 716 18 in in IN cord-335975-m6lkrehi 716 19 only only RB cord-335975-m6lkrehi 716 20 13 13 CD cord-335975-m6lkrehi 716 21 ( ( -LRB- cord-335975-m6lkrehi 716 22 32 32 CD cord-335975-m6lkrehi 716 23 % % NN cord-335975-m6lkrehi 716 24 ) ) -RRB- cord-335975-m6lkrehi 716 25 patients patient NNS cord-335975-m6lkrehi 716 26 . . . cord-335975-m6lkrehi 717 1 Main main JJ cord-335975-m6lkrehi 717 2 causes cause NNS cord-335975-m6lkrehi 717 3 of of IN cord-335975-m6lkrehi 717 4 hypothyroidism hypothyroidism NN cord-335975-m6lkrehi 717 5 were be VBD cord-335975-m6lkrehi 717 6 thyroiditis thyroiditis NN cord-335975-m6lkrehi 717 7 and and CC cord-335975-m6lkrehi 717 8 thyroidectomy thyroidectomy NN cord-335975-m6lkrehi 717 9 . . . cord-335975-m6lkrehi 718 1 Thirtytwo Thirtytwo NNP cord-335975-m6lkrehi 718 2 ( ( -LRB- cord-335975-m6lkrehi 718 3 80 80 CD cord-335975-m6lkrehi 718 4 % % NN cord-335975-m6lkrehi 718 5 ) ) -RRB- cord-335975-m6lkrehi 719 1 patients patient NNS cord-335975-m6lkrehi 719 2 had have VBD cord-335975-m6lkrehi 719 3 alteration alteration NN cord-335975-m6lkrehi 719 4 of of IN cord-335975-m6lkrehi 719 5 consciousness consciousness NN cord-335975-m6lkrehi 719 6 with with IN cord-335975-m6lkrehi 719 7 a a DT cord-335975-m6lkrehi 719 8 median median JJ cord-335975-m6lkrehi 719 9 Glasgow Glasgow NNP cord-335975-m6lkrehi 719 10 score score NN cord-335975-m6lkrehi 719 11 at at IN cord-335975-m6lkrehi 719 12 10 10 CD cord-335975-m6lkrehi 719 13 ( ( -LRB- cord-335975-m6lkrehi 719 14 6 6 CD cord-335975-m6lkrehi 719 15 - - SYM cord-335975-m6lkrehi 719 16 13 13 CD cord-335975-m6lkrehi 719 17 ) ) -RRB- cord-335975-m6lkrehi 719 18 . . . cord-335975-m6lkrehi 720 1 In in IN cord-335975-m6lkrehi 720 2 addition addition NN cord-335975-m6lkrehi 720 3 , , , cord-335975-m6lkrehi 720 4 median median JJ cord-335975-m6lkrehi 720 5 heart heart NN cord-335975-m6lkrehi 720 6 rate rate NN cord-335975-m6lkrehi 720 7 at at IN cord-335975-m6lkrehi 720 8 ICU ICU NNP cord-335975-m6lkrehi 720 9 admission admission NN cord-335975-m6lkrehi 720 10 was be VBD cord-335975-m6lkrehi 720 11 50 50 CD cord-335975-m6lkrehi 720 12 ( ( -LRB- cord-335975-m6lkrehi 720 13 35 35 CD cord-335975-m6lkrehi 720 14 - - SYM cord-335975-m6lkrehi 720 15 65 65 CD cord-335975-m6lkrehi 720 16 ) ) -RRB- cord-335975-m6lkrehi 720 17 bpm bpm NN cord-335975-m6lkrehi 720 18 while while IN cord-335975-m6lkrehi 720 19 hypothermia hypothermia NN cord-335975-m6lkrehi 720 20 < < XX cord-335975-m6lkrehi 720 21 35 35 CD cord-335975-m6lkrehi 720 22 ° ° NN cord-335975-m6lkrehi 720 23 C C NNP cord-335975-m6lkrehi 720 24 was be VBD cord-335975-m6lkrehi 720 25 noted note VBN cord-335975-m6lkrehi 720 26 in in IN cord-335975-m6lkrehi 720 27 24 24 CD cord-335975-m6lkrehi 720 28 ( ( -LRB- cord-335975-m6lkrehi 720 29 60 60 CD cord-335975-m6lkrehi 720 30 % % NN cord-335975-m6lkrehi 720 31 ) ) -RRB- cord-335975-m6lkrehi 720 32 patients patient NNS cord-335975-m6lkrehi 720 33 . . . cord-335975-m6lkrehi 721 1 Median median JJ cord-335975-m6lkrehi 721 2 TSH TSH NNP cord-335975-m6lkrehi 721 3 level level NN cord-335975-m6lkrehi 721 4 at at IN cord-335975-m6lkrehi 721 5 admission admission NN cord-335975-m6lkrehi 721 6 was be VBD cord-335975-m6lkrehi 721 7 78 78 CD cord-335975-m6lkrehi 722 1 ( ( -LRB- cord-335975-m6lkrehi 722 2 43 43 CD cord-335975-m6lkrehi 722 3 - - SYM cord-335975-m6lkrehi 722 4 135 135 CD cord-335975-m6lkrehi 722 5 ) ) -RRB- cord-335975-m6lkrehi 722 6 mUI mui NN cord-335975-m6lkrehi 722 7 l l NNP cord-335975-m6lkrehi 722 8 , , , cord-335975-m6lkrehi 722 9 T3 T3 NNP cord-335975-m6lkrehi 722 10 and and CC cord-335975-m6lkrehi 722 11 T4 T4 NNP cord-335975-m6lkrehi 722 12 levels level NNS cord-335975-m6lkrehi 722 13 respectively respectively RB cord-335975-m6lkrehi 722 14 0 0 NFP cord-335975-m6lkrehi 722 15 ( ( -LRB- cord-335975-m6lkrehi 722 16 0 0 CD cord-335975-m6lkrehi 722 17 - - SYM cord-335975-m6lkrehi 722 18 0.45 0.45 CD cord-335975-m6lkrehi 722 19 ) ) -RRB- cord-335975-m6lkrehi 723 1 pmol pmol NNP cord-335975-m6lkrehi 723 2 l l NNP cord-335975-m6lkrehi 723 3 and and CC cord-335975-m6lkrehi 723 4 2 2 CD cord-335975-m6lkrehi 724 1 ( ( -LRB- cord-335975-m6lkrehi 724 2 0 0 CD cord-335975-m6lkrehi 724 3 - - SYM cord-335975-m6lkrehi 724 4 5.07 5.07 CD cord-335975-m6lkrehi 724 5 ) ) -RRB- cord-335975-m6lkrehi 724 6 pmol pmol NNP cord-335975-m6lkrehi 724 7 l. l. NNP cord-335975-m6lkrehi 724 8 Rhabdomyolysis Rhabdomyolysis NNP cord-335975-m6lkrehi 724 9 was be VBD cord-335975-m6lkrehi 724 10 frequent frequent JJ cord-335975-m6lkrehi 724 11 with with IN cord-335975-m6lkrehi 724 12 median median JJ cord-335975-m6lkrehi 724 13 CPK CPK NNP cord-335975-m6lkrehi 724 14 level level NN cord-335975-m6lkrehi 724 15 539 539 CD cord-335975-m6lkrehi 724 16 ( ( -LRB- cord-335975-m6lkrehi 724 17 192 192 CD cord-335975-m6lkrehi 724 18 - - SYM cord-335975-m6lkrehi 724 19 1500 1500 CD cord-335975-m6lkrehi 724 20 ) ) -RRB- cord-335975-m6lkrehi 725 1 UI UI NNP cord-335975-m6lkrehi 725 2 l. l. NNP cord-335975-m6lkrehi 725 3 Organ Organ NNP cord-335975-m6lkrehi 725 4 support support NN cord-335975-m6lkrehi 725 5 including include VBG cord-335975-m6lkrehi 725 6 mechanical mechanical JJ cord-335975-m6lkrehi 725 7 ventilation ventilation NN cord-335975-m6lkrehi 725 8 , , , cord-335975-m6lkrehi 725 9 catecholamine catecholamine NN cord-335975-m6lkrehi 725 10 infusion infusion NN cord-335975-m6lkrehi 725 11 and and CC cord-335975-m6lkrehi 725 12 , , , cord-335975-m6lkrehi 725 13 renal renal JJ cord-335975-m6lkrehi 725 14 replacement replacement NN cord-335975-m6lkrehi 725 15 therapy therapy NN cord-335975-m6lkrehi 725 16 were be VBD cord-335975-m6lkrehi 725 17 respectively respectively RB cord-335975-m6lkrehi 725 18 used use VBN cord-335975-m6lkrehi 725 19 in in IN cord-335975-m6lkrehi 725 20 58 58 CD cord-335975-m6lkrehi 725 21 , , , cord-335975-m6lkrehi 725 22 45 45 CD cord-335975-m6lkrehi 725 23 , , , cord-335975-m6lkrehi 725 24 and and CC cord-335975-m6lkrehi 725 25 20 20 CD cord-335975-m6lkrehi 725 26 % % NN cord-335975-m6lkrehi 725 27 patients patient NNS cord-335975-m6lkrehi 725 28 . . . cord-335975-m6lkrehi 726 1 Lastly lastly RB cord-335975-m6lkrehi 726 2 , , , cord-335975-m6lkrehi 726 3 70 70 CD cord-335975-m6lkrehi 726 4 % % NN cord-335975-m6lkrehi 726 5 patients patient NNS cord-335975-m6lkrehi 726 6 received receive VBD cord-335975-m6lkrehi 726 7 oral oral JJ cord-335975-m6lkrehi 726 8 levothyroxine levothyroxine NN cord-335975-m6lkrehi 726 9 whereas whereas IN cord-335975-m6lkrehi 726 10 the the DT cord-335975-m6lkrehi 726 11 intravenous intravenous JJ cord-335975-m6lkrehi 726 12 form form NN cord-335975-m6lkrehi 726 13 was be VBD cord-335975-m6lkrehi 726 14 used use VBN cord-335975-m6lkrehi 726 15 in in IN cord-335975-m6lkrehi 726 16 others other NNS cord-335975-m6lkrehi 726 17 . . . cord-335975-m6lkrehi 727 1 Overall overall JJ cord-335975-m6lkrehi 727 2 ICUmortality icumortality NN cord-335975-m6lkrehi 727 3 was be VBD cord-335975-m6lkrehi 727 4 22 22 CD cord-335975-m6lkrehi 727 5 % % NN cord-335975-m6lkrehi 727 6 . . . cord-335975-m6lkrehi 728 1 Our -PRON- PRP$ cord-335975-m6lkrehi 728 2 preliminary preliminary JJ cord-335975-m6lkrehi 728 3 data datum NNS cord-335975-m6lkrehi 728 4 showed show VBD cord-335975-m6lkrehi 728 5 that that IN cord-335975-m6lkrehi 728 6 severe severe JJ cord-335975-m6lkrehi 728 7 manifestations manifestation NNS cord-335975-m6lkrehi 728 8 of of IN cord-335975-m6lkrehi 728 9 hypothyroidism hypothyroidism NN cord-335975-m6lkrehi 728 10 leading lead VBG cord-335975-m6lkrehi 728 11 to to IN cord-335975-m6lkrehi 728 12 ICU ICU NNP cord-335975-m6lkrehi 728 13 admission admission NN cord-335975-m6lkrehi 728 14 represent represent VBP cord-335975-m6lkrehi 728 15 de de FW cord-335975-m6lkrehi 728 16 novo novo NNP cord-335975-m6lkrehi 728 17 hypothyroidism hypothyroidism NN cord-335975-m6lkrehi 728 18 in in IN cord-335975-m6lkrehi 728 19 two two CD cord-335975-m6lkrehi 728 20 - - HYPH cord-335975-m6lkrehi 728 21 thirds third NNS cord-335975-m6lkrehi 728 22 of of IN cord-335975-m6lkrehi 728 23 patients patient NNS cord-335975-m6lkrehi 728 24 , , , cord-335975-m6lkrehi 728 25 leading lead VBG cord-335975-m6lkrehi 728 26 to to IN cord-335975-m6lkrehi 728 27 a a DT cord-335975-m6lkrehi 728 28 high high JJ cord-335975-m6lkrehi 728 29 mortality mortality NN cord-335975-m6lkrehi 728 30 . . . cord-335975-m6lkrehi 729 1 Introduction introduction NN cord-335975-m6lkrehi 729 2 : : : cord-335975-m6lkrehi 729 3 When when WRB cord-335975-m6lkrehi 729 4 it -PRON- PRP cord-335975-m6lkrehi 729 5 comes come VBZ cord-335975-m6lkrehi 729 6 to to IN cord-335975-m6lkrehi 729 7 infections infection NNS cord-335975-m6lkrehi 729 8 of of IN cord-335975-m6lkrehi 729 9 the the DT cord-335975-m6lkrehi 729 10 central central JJ cord-335975-m6lkrehi 729 11 nervous nervous JJ cord-335975-m6lkrehi 729 12 system system NN cord-335975-m6lkrehi 729 13 ( ( -LRB- cord-335975-m6lkrehi 729 14 CNS CNS NNP cord-335975-m6lkrehi 729 15 ) ) -RRB- cord-335975-m6lkrehi 729 16 , , , cord-335975-m6lkrehi 729 17 the the DT cord-335975-m6lkrehi 729 18 greatest great JJS cord-335975-m6lkrehi 729 19 challenge challenge NN cord-335975-m6lkrehi 729 20 in in IN cord-335975-m6lkrehi 729 21 the the DT cord-335975-m6lkrehi 729 22 Emergency Emergency NNP cord-335975-m6lkrehi 729 23 Department Department NNP cord-335975-m6lkrehi 729 24 ( ( -LRB- cord-335975-m6lkrehi 729 25 ED ED NNP cord-335975-m6lkrehi 729 26 ) ) -RRB- cord-335975-m6lkrehi 729 27 is be VBZ cord-335975-m6lkrehi 729 28 to to TO cord-335975-m6lkrehi 729 29 identify identify VB cord-335975-m6lkrehi 729 30 patients patient NNS cord-335975-m6lkrehi 729 31 that that WDT cord-335975-m6lkrehi 729 32 have have VBP cord-335975-m6lkrehi 729 33 a a DT cord-335975-m6lkrehi 729 34 rare rare JJ cord-335975-m6lkrehi 729 35 life life NN cord-335975-m6lkrehi 729 36 - - HYPH cord-335975-m6lkrehi 729 37 threatening threaten VBG cord-335975-m6lkrehi 729 38 diagnosis diagnosis NN cord-335975-m6lkrehi 729 39 . . . cord-335975-m6lkrehi 730 1 Alone alone JJ cord-335975-m6lkrehi 730 2 or or CC cord-335975-m6lkrehi 730 3 in in IN cord-335975-m6lkrehi 730 4 combination combination NN cord-335975-m6lkrehi 730 5 , , , cord-335975-m6lkrehi 730 6 fever fever NN cord-335975-m6lkrehi 730 7 , , , cord-335975-m6lkrehi 730 8 headache headache NN cord-335975-m6lkrehi 730 9 , , , cord-335975-m6lkrehi 730 10 altered alter VBN cord-335975-m6lkrehi 730 11 mental mental JJ cord-335975-m6lkrehi 730 12 status status NN cord-335975-m6lkrehi 730 13 encompass encompass VBP cord-335975-m6lkrehi 730 14 a a DT cord-335975-m6lkrehi 730 15 broad broad JJ cord-335975-m6lkrehi 730 16 differential differential JJ cord-335975-m6lkrehi 730 17 diagnosis diagnosis NN cord-335975-m6lkrehi 730 18 . . . cord-335975-m6lkrehi 731 1 Antibiotics antibiotic NNS cord-335975-m6lkrehi 731 2 or or CC cord-335975-m6lkrehi 731 3 antiviral antiviral JJ cord-335975-m6lkrehi 731 4 therapy therapy NN cord-335975-m6lkrehi 731 5 should should MD cord-335975-m6lkrehi 731 6 be be VB cord-335975-m6lkrehi 731 7 given give VBN cord-335975-m6lkrehi 731 8 as as RB cord-335975-m6lkrehi 731 9 soon soon RB cord-335975-m6lkrehi 731 10 as as IN cord-335975-m6lkrehi 731 11 possible possible JJ cord-335975-m6lkrehi 731 12 , , , cord-335975-m6lkrehi 731 13 ideally ideally RB cord-335975-m6lkrehi 731 14 after after IN cord-335975-m6lkrehi 731 15 both both DT cord-335975-m6lkrehi 731 16 blood blood NN cord-335975-m6lkrehi 731 17 and and CC cord-335975-m6lkrehi 731 18 cerebrospinal cerebrospinal NN cord-335975-m6lkrehi 731 19 fluid fluid NN cord-335975-m6lkrehi 731 20 ( ( -LRB- cord-335975-m6lkrehi 731 21 CSF CSF NNP cord-335975-m6lkrehi 731 22 ) ) -RRB- cord-335975-m6lkrehi 731 23 have have VBP cord-335975-m6lkrehi 731 24 been be VBN cord-335975-m6lkrehi 731 25 obtained obtain VBN cord-335975-m6lkrehi 731 26 . . . cord-335975-m6lkrehi 732 1 Early early JJ cord-335975-m6lkrehi 732 2 treatment treatment NN cord-335975-m6lkrehi 732 3 is be VBZ cord-335975-m6lkrehi 732 4 associated associate VBN cord-335975-m6lkrehi 732 5 with with IN cord-335975-m6lkrehi 732 6 a a DT cord-335975-m6lkrehi 732 7 lower low JJR cord-335975-m6lkrehi 732 8 mortality mortality NN cord-335975-m6lkrehi 732 9 . . . cord-335975-m6lkrehi 733 1 Patients patient NNS cord-335975-m6lkrehi 733 2 and and CC cord-335975-m6lkrehi 733 3 methods method NNS cord-335975-m6lkrehi 733 4 : : : cord-335975-m6lkrehi 733 5 We -PRON- PRP cord-335975-m6lkrehi 733 6 present present VBP cord-335975-m6lkrehi 733 7 here here RB cord-335975-m6lkrehi 733 8 , , , cord-335975-m6lkrehi 733 9 a a DT cord-335975-m6lkrehi 733 10 four four CD cord-335975-m6lkrehi 733 11 - - HYPH cord-335975-m6lkrehi 733 12 year year NN cord-335975-m6lkrehi 733 13 ( ( -LRB- cord-335975-m6lkrehi 733 14 2012 2012 CD cord-335975-m6lkrehi 733 15 - - SYM cord-335975-m6lkrehi 733 16 2015 2015 CD cord-335975-m6lkrehi 733 17 ) ) -RRB- cord-335975-m6lkrehi 733 18 retrospective retrospective JJ cord-335975-m6lkrehi 733 19 and and CC cord-335975-m6lkrehi 733 20 monocentric monocentric JJ cord-335975-m6lkrehi 733 21 study study NN cord-335975-m6lkrehi 733 22 . . . cord-335975-m6lkrehi 734 1 During during IN cord-335975-m6lkrehi 734 2 the the DT cord-335975-m6lkrehi 734 3 period period NN cord-335975-m6lkrehi 734 4 of of IN cord-335975-m6lkrehi 734 5 the the DT cord-335975-m6lkrehi 734 6 study study NN cord-335975-m6lkrehi 734 7 , , , cord-335975-m6lkrehi 734 8 we -PRON- PRP cord-335975-m6lkrehi 734 9 included include VBD cord-335975-m6lkrehi 734 10 all all DT cord-335975-m6lkrehi 734 11 adult adult NN cord-335975-m6lkrehi 734 12 patients patient NNS cord-335975-m6lkrehi 734 13 with with IN cord-335975-m6lkrehi 734 14 the the DT cord-335975-m6lkrehi 734 15 diagnosis diagnosis NN cord-335975-m6lkrehi 734 16 of of IN cord-335975-m6lkrehi 734 17 CNS CNS NNP cord-335975-m6lkrehi 734 18 infection infection NN cord-335975-m6lkrehi 734 19 ( ( -LRB- cord-335975-m6lkrehi 734 20 positive positive JJ cord-335975-m6lkrehi 734 21 CSF csf NN cord-335975-m6lkrehi 734 22 culture culture NN cord-335975-m6lkrehi 734 23 ) ) -RRB- cord-335975-m6lkrehi 734 24 . . . cord-335975-m6lkrehi 735 1 We -PRON- PRP cord-335975-m6lkrehi 735 2 collected collect VBD cord-335975-m6lkrehi 735 3 and and CC cord-335975-m6lkrehi 735 4 analyzed analyze VBD cord-335975-m6lkrehi 735 5 all all DT cord-335975-m6lkrehi 735 6 clinical clinical JJ cord-335975-m6lkrehi 735 7 , , , cord-335975-m6lkrehi 735 8 biological biological JJ cord-335975-m6lkrehi 735 9 , , , cord-335975-m6lkrehi 735 10 imaging imaging NN cord-335975-m6lkrehi 735 11 , , , cord-335975-m6lkrehi 735 12 treatments treatment NNS cord-335975-m6lkrehi 735 13 and and CC cord-335975-m6lkrehi 735 14 evolution evolution NN cord-335975-m6lkrehi 735 15 datas data NNS cord-335975-m6lkrehi 735 16 during during IN cord-335975-m6lkrehi 735 17 the the DT cord-335975-m6lkrehi 735 18 stay stay NN cord-335975-m6lkrehi 735 19 . . . cord-335975-m6lkrehi 736 1 A a DT cord-335975-m6lkrehi 736 2 total total NN cord-335975-m6lkrehi 736 3 of of IN cord-335975-m6lkrehi 736 4 67 67 CD cord-335975-m6lkrehi 736 5 patients patient NNS cord-335975-m6lkrehi 736 6 with with IN cord-335975-m6lkrehi 736 7 CNS CNS NNP cord-335975-m6lkrehi 736 8 infection infection NN cord-335975-m6lkrehi 736 9 have have VBP cord-335975-m6lkrehi 736 10 been be VBN cord-335975-m6lkrehi 736 11 included include VBN cord-335975-m6lkrehi 736 12 for for IN cord-335975-m6lkrehi 736 13 statistical statistical JJ cord-335975-m6lkrehi 736 14 analysis analysis NN cord-335975-m6lkrehi 736 15 . . . cord-335975-m6lkrehi 737 1 We -PRON- PRP cord-335975-m6lkrehi 737 2 analyzed analyze VBD cord-335975-m6lkrehi 737 3 a a DT cord-335975-m6lkrehi 737 4 second second JJ cord-335975-m6lkrehi 737 5 group group NN cord-335975-m6lkrehi 737 6 ( ( -LRB- cord-335975-m6lkrehi 737 7 n n NN cord-335975-m6lkrehi 737 8 = = SYM cord-335975-m6lkrehi 737 9 25 25 CD cord-335975-m6lkrehi 737 10 ) ) -RRB- cord-335975-m6lkrehi 737 11 with with IN cord-335975-m6lkrehi 737 12 suspected suspect VBN cord-335975-m6lkrehi 737 13 CNS CNS NNP cord-335975-m6lkrehi 737 14 infection infection NN cord-335975-m6lkrehi 737 15 ( ( -LRB- cord-335975-m6lkrehi 737 16 negative negative JJ cord-335975-m6lkrehi 737 17 CSF CSF NNP cord-335975-m6lkrehi 737 18 ) ) -RRB- cord-335975-m6lkrehi 737 19 as as IN cord-335975-m6lkrehi 737 20 a a DT cord-335975-m6lkrehi 737 21 control control NN cord-335975-m6lkrehi 737 22 group group NN cord-335975-m6lkrehi 737 23 . . . cord-335975-m6lkrehi 738 1 Results result NNS cord-335975-m6lkrehi 738 2 : : : cord-335975-m6lkrehi 739 1 In in IN cord-335975-m6lkrehi 739 2 the the DT cord-335975-m6lkrehi 739 3 study study NN cord-335975-m6lkrehi 739 4 population population NN cord-335975-m6lkrehi 739 5 , , , cord-335975-m6lkrehi 739 6 mean mean JJ cord-335975-m6lkrehi 739 7 age age NN cord-335975-m6lkrehi 739 8 was be VBD cord-335975-m6lkrehi 739 9 43 43 CD cord-335975-m6lkrehi 739 10 ± ± CD cord-335975-m6lkrehi 739 11 21.5 21.5 CD cord-335975-m6lkrehi 739 12 years year NNS cord-335975-m6lkrehi 739 13 old old JJ cord-335975-m6lkrehi 739 14 and and CC cord-335975-m6lkrehi 739 15 the the DT cord-335975-m6lkrehi 739 16 sex sex NN cord-335975-m6lkrehi 739 17 - - HYPH cord-335975-m6lkrehi 739 18 ratio ratio NN cord-335975-m6lkrehi 739 19 was be VBD cord-335975-m6lkrehi 739 20 1.2 1.2 CD cord-335975-m6lkrehi 739 21 . . . cord-335975-m6lkrehi 740 1 There there EX cord-335975-m6lkrehi 740 2 were be VBD cord-335975-m6lkrehi 740 3 no no DT cord-335975-m6lkrehi 740 4 difference difference NN cord-335975-m6lkrehi 740 5 between between IN cord-335975-m6lkrehi 740 6 the the DT cord-335975-m6lkrehi 740 7 two two CD cord-335975-m6lkrehi 740 8 groups group NNS cord-335975-m6lkrehi 740 9 in in IN cord-335975-m6lkrehi 740 10 terms term NNS cord-335975-m6lkrehi 740 11 of of IN cord-335975-m6lkrehi 740 12 clinical clinical JJ cord-335975-m6lkrehi 740 13 signs sign NNS cord-335975-m6lkrehi 740 14 except except IN cord-335975-m6lkrehi 740 15 for for IN cord-335975-m6lkrehi 740 16 more more RBR cord-335975-m6lkrehi 740 17 altered altered JJ cord-335975-m6lkrehi 740 18 mental mental JJ cord-335975-m6lkrehi 740 19 status status NN cord-335975-m6lkrehi 740 20 in in IN cord-335975-m6lkrehi 740 21 the the DT cord-335975-m6lkrehi 740 22 control control NN cord-335975-m6lkrehi 740 23 group group NN cord-335975-m6lkrehi 740 24 ( ( -LRB- cord-335975-m6lkrehi 740 25 p p NN cord-335975-m6lkrehi 740 26 = = SYM cord-335975-m6lkrehi 740 27 0.02 0.02 CD cord-335975-m6lkrehi 740 28 ) ) -RRB- cord-335975-m6lkrehi 740 29 . . . cord-335975-m6lkrehi 741 1 All all DT cord-335975-m6lkrehi 741 2 patients patient NNS cord-335975-m6lkrehi 741 3 of of IN cord-335975-m6lkrehi 741 4 the the DT cord-335975-m6lkrehi 741 5 study study NN cord-335975-m6lkrehi 741 6 ( ( -LRB- cord-335975-m6lkrehi 741 7 n n NN cord-335975-m6lkrehi 741 8 = = SYM cord-335975-m6lkrehi 741 9 92 92 CD cord-335975-m6lkrehi 741 10 ) ) -RRB- cord-335975-m6lkrehi 741 11 benefited benefit VBD cord-335975-m6lkrehi 741 12 of of IN cord-335975-m6lkrehi 741 13 lumbar lumbar NN cord-335975-m6lkrehi 741 14 puncture puncture NN cord-335975-m6lkrehi 741 15 ( ( -LRB- cord-335975-m6lkrehi 741 16 LP LP NNP cord-335975-m6lkrehi 741 17 ) ) -RRB- cord-335975-m6lkrehi 741 18 in in IN cord-335975-m6lkrehi 741 19 the the DT cord-335975-m6lkrehi 741 20 ED ED NNP cord-335975-m6lkrehi 741 21 with with IN cord-335975-m6lkrehi 741 22 an an DT cord-335975-m6lkrehi 741 23 average average JJ cord-335975-m6lkrehi 741 24 time time NN cord-335975-m6lkrehi 741 25 of of IN cord-335975-m6lkrehi 741 26 381 381 CD cord-335975-m6lkrehi 741 27 ± ± CD cord-335975-m6lkrehi 741 28 370 370 CD cord-335975-m6lkrehi 741 29 min min NN cord-335975-m6lkrehi 741 30 after after IN cord-335975-m6lkrehi 741 31 admission admission NN cord-335975-m6lkrehi 741 32 . . . cord-335975-m6lkrehi 742 1 This this DT cord-335975-m6lkrehi 742 2 delay delay NN cord-335975-m6lkrehi 742 3 was be VBD cord-335975-m6lkrehi 742 4 the the DT cord-335975-m6lkrehi 742 5 same same JJ cord-335975-m6lkrehi 742 6 between between IN cord-335975-m6lkrehi 742 7 the the DT cord-335975-m6lkrehi 742 8 two two CD cord-335975-m6lkrehi 742 9 groups group NNS cord-335975-m6lkrehi 742 10 ( ( -LRB- cord-335975-m6lkrehi 742 11 p p NN cord-335975-m6lkrehi 742 12 = = SYM cord-335975-m6lkrehi 742 13 0.76 0.76 CD cord-335975-m6lkrehi 742 14 ) ) -RRB- cord-335975-m6lkrehi 742 15 but but CC cord-335975-m6lkrehi 742 16 was be VBD cord-335975-m6lkrehi 742 17 significantly significantly RB cord-335975-m6lkrehi 742 18 higher high JJR cord-335975-m6lkrehi 742 19 in in IN cord-335975-m6lkrehi 742 20 the the DT cord-335975-m6lkrehi 742 21 encephalitis encephalitis JJ cord-335975-m6lkrehi 742 22 subgroup subgroup NN cord-335975-m6lkrehi 742 23 ( ( -LRB- cord-335975-m6lkrehi 742 24 n n NN cord-335975-m6lkrehi 742 25 = = SYM cord-335975-m6lkrehi 742 26 13 13 CD cord-335975-m6lkrehi 742 27 , , , cord-335975-m6lkrehi 742 28 p p NN cord-335975-m6lkrehi 742 29 = = SYM cord-335975-m6lkrehi 742 30 0.03 0.03 CD cord-335975-m6lkrehi 742 31 ) ) -RRB- cord-335975-m6lkrehi 742 32 . . . cord-335975-m6lkrehi 743 1 Patients patient NNS cord-335975-m6lkrehi 743 2 who who WP cord-335975-m6lkrehi 743 3 had have VBD cord-335975-m6lkrehi 743 4 imaging image VBG cord-335975-m6lkrehi 743 5 ( ( -LRB- cord-335975-m6lkrehi 743 6 CT CT NNP cord-335975-m6lkrehi 743 7 or or CC cord-335975-m6lkrehi 743 8 MRI MRI NNP cord-335975-m6lkrehi 743 9 ) ) -RRB- cord-335975-m6lkrehi 743 10 during during IN cord-335975-m6lkrehi 743 11 the the DT cord-335975-m6lkrehi 743 12 ED ED NNP cord-335975-m6lkrehi 743 13 stay stay NN cord-335975-m6lkrehi 743 14 had have VBD cord-335975-m6lkrehi 743 15 more more RBR cord-335975-m6lkrehi 743 16 likely likely RB cord-335975-m6lkrehi 743 17 a a DT cord-335975-m6lkrehi 743 18 delay delay NN cord-335975-m6lkrehi 743 19 in in IN cord-335975-m6lkrehi 743 20 LP lp NN cord-335975-m6lkrehi 743 21 realization realization NN cord-335975-m6lkrehi 743 22 ( ( -LRB- cord-335975-m6lkrehi 743 23 450 450 CD cord-335975-m6lkrehi 743 24 vs vs IN cord-335975-m6lkrehi 743 25 193 193 CD cord-335975-m6lkrehi 743 26 min min NN cord-335975-m6lkrehi 743 27 , , , cord-335975-m6lkrehi 743 28 p p NN cord-335975-m6lkrehi 743 29 = = SYM cord-335975-m6lkrehi 743 30 0.0005 0.0005 CD cord-335975-m6lkrehi 743 31 ) ) -RRB- cord-335975-m6lkrehi 743 32 . . . cord-335975-m6lkrehi 744 1 Patients patient NNS cord-335975-m6lkrehi 744 2 where where WRB cord-335975-m6lkrehi 744 3 the the DT cord-335975-m6lkrehi 744 4 CNS CNS NNP cord-335975-m6lkrehi 744 5 infection infection NN cord-335975-m6lkrehi 744 6 diagnosis diagnosis NN cord-335975-m6lkrehi 744 7 was be VBD cord-335975-m6lkrehi 744 8 firstly firstly RB cord-335975-m6lkrehi 744 9 evoke evoke VBN cord-335975-m6lkrehi 744 10 by by IN cord-335975-m6lkrehi 744 11 the the DT cord-335975-m6lkrehi 744 12 triage triage NN cord-335975-m6lkrehi 744 13 nurse nurse NN cord-335975-m6lkrehi 744 14 had have VBD cord-335975-m6lkrehi 744 15 LP LP NNP cord-335975-m6lkrehi 744 16 more more RBR cord-335975-m6lkrehi 744 17 quickly quickly RB cord-335975-m6lkrehi 745 1 ( ( -LRB- cord-335975-m6lkrehi 745 2 p p NN cord-335975-m6lkrehi 745 3 = = SYM cord-335975-m6lkrehi 745 4 0.03 0.03 CD cord-335975-m6lkrehi 745 5 ) ) -RRB- cord-335975-m6lkrehi 745 6 . . . cord-335975-m6lkrehi 746 1 The the DT cord-335975-m6lkrehi 746 2 median median JJ cord-335975-m6lkrehi 746 3 door door NN cord-335975-m6lkrehi 746 4 to to IN cord-335975-m6lkrehi 746 5 - - HYPH cord-335975-m6lkrehi 746 6 antibiotic antibiotic JJ cord-335975-m6lkrehi 746 7 - - HYPH cord-335975-m6lkrehi 746 8 time time NN cord-335975-m6lkrehi 746 9 was be VBD cord-335975-m6lkrehi 746 10 339 339 CD cord-335975-m6lkrehi 746 11 min min NN cord-335975-m6lkrehi 746 12 with with IN cord-335975-m6lkrehi 746 13 no no DT cord-335975-m6lkrehi 746 14 difference difference NN cord-335975-m6lkrehi 746 15 between between IN cord-335975-m6lkrehi 746 16 the the DT cord-335975-m6lkrehi 746 17 two two CD cord-335975-m6lkrehi 746 18 groups group NNS cord-335975-m6lkrehi 746 19 of of IN cord-335975-m6lkrehi 746 20 the the DT cord-335975-m6lkrehi 746 21 study study NN cord-335975-m6lkrehi 746 22 ( ( -LRB- cord-335975-m6lkrehi 746 23 p p NN cord-335975-m6lkrehi 746 24 = = SYM cord-335975-m6lkrehi 746 25 0.7 0.7 CD cord-335975-m6lkrehi 746 26 ) ) -RRB- cord-335975-m6lkrehi 746 27 . . . cord-335975-m6lkrehi 747 1 94 94 CD cord-335975-m6lkrehi 747 2 % % NN cord-335975-m6lkrehi 747 3 of of IN cord-335975-m6lkrehi 747 4 all all DT cord-335975-m6lkrehi 747 5 patients patient NNS cord-335975-m6lkrehi 747 6 were be VBD cord-335975-m6lkrehi 747 7 hospitalized hospitalize VBN cord-335975-m6lkrehi 747 8 for for IN cord-335975-m6lkrehi 747 9 an an DT cord-335975-m6lkrehi 747 10 average average JJ cord-335975-m6lkrehi 747 11 length length NN cord-335975-m6lkrehi 747 12 of of IN cord-335975-m6lkrehi 747 13 stay stay NN cord-335975-m6lkrehi 747 14 of of IN cord-335975-m6lkrehi 747 15 11.7 11.7 CD cord-335975-m6lkrehi 747 16 ± ± NNP cord-335975-m6lkrehi 747 17 15.5 15.5 CD cord-335975-m6lkrehi 747 18 days day NNS cord-335975-m6lkrehi 747 19 and and CC cord-335975-m6lkrehi 747 20 10 10 CD cord-335975-m6lkrehi 747 21 % % NN cord-335975-m6lkrehi 747 22 of of IN cord-335975-m6lkrehi 747 23 them -PRON- PRP cord-335975-m6lkrehi 747 24 were be VBD cord-335975-m6lkrehi 747 25 admitted admit VBN cord-335975-m6lkrehi 747 26 in in IN cord-335975-m6lkrehi 747 27 the the DT cord-335975-m6lkrehi 747 28 ICU ICU NNP cord-335975-m6lkrehi 747 29 . . . cord-335975-m6lkrehi 748 1 The the DT cord-335975-m6lkrehi 748 2 inhospital inhospital JJ cord-335975-m6lkrehi 748 3 mortality mortality NN cord-335975-m6lkrehi 748 4 was be VBD cord-335975-m6lkrehi 748 5 14 14 CD cord-335975-m6lkrehi 748 6 % % NN cord-335975-m6lkrehi 748 7 in in IN cord-335975-m6lkrehi 748 8 the the DT cord-335975-m6lkrehi 748 9 study study NN cord-335975-m6lkrehi 748 10 population population NN cord-335975-m6lkrehi 748 11 . . . cord-335975-m6lkrehi 749 1 Introduction introduction NN cord-335975-m6lkrehi 749 2 : : : cord-335975-m6lkrehi 750 1 There there EX cord-335975-m6lkrehi 750 2 are be VBP cord-335975-m6lkrehi 750 3 numerous numerous JJ cord-335975-m6lkrehi 750 4 causes cause NNS cord-335975-m6lkrehi 750 5 of of IN cord-335975-m6lkrehi 750 6 acute acute JJ cord-335975-m6lkrehi 750 7 exacerbations exacerbation NNS cord-335975-m6lkrehi 750 8 of of IN cord-335975-m6lkrehi 750 9 COPD COPD NNP cord-335975-m6lkrehi 750 10 ( ( -LRB- cord-335975-m6lkrehi 750 11 AECOPD AECOPD NNP cord-335975-m6lkrehi 750 12 ) ) -RRB- cord-335975-m6lkrehi 750 13 , , , cord-335975-m6lkrehi 750 14 the the DT cord-335975-m6lkrehi 750 15 most most RBS cord-335975-m6lkrehi 750 16 common common JJ cord-335975-m6lkrehi 750 17 of of IN cord-335975-m6lkrehi 750 18 which which WDT cord-335975-m6lkrehi 750 19 are be VBP cord-335975-m6lkrehi 750 20 bronchial bronchial JJ cord-335975-m6lkrehi 750 21 and and CC cord-335975-m6lkrehi 750 22 or or CC cord-335975-m6lkrehi 750 23 pulmonary pulmonary JJ cord-335975-m6lkrehi 750 24 infections infection NNS cord-335975-m6lkrehi 750 25 . . . cord-335975-m6lkrehi 751 1 Viral viral JJ cord-335975-m6lkrehi 751 2 etiologies etiology NNS cord-335975-m6lkrehi 751 3 may may MD cord-335975-m6lkrehi 751 4 account account VB cord-335975-m6lkrehi 751 5 for for IN cord-335975-m6lkrehi 751 6 30 30 CD cord-335975-m6lkrehi 751 7 % % NN cord-335975-m6lkrehi 751 8 of of IN cord-335975-m6lkrehi 751 9 AECOPD AECOPD NNP cord-335975-m6lkrehi 751 10 , , , cord-335975-m6lkrehi 751 11 but but CC cord-335975-m6lkrehi 751 12 this this DT cord-335975-m6lkrehi 751 13 rate rate NN cord-335975-m6lkrehi 751 14 is be VBZ cord-335975-m6lkrehi 751 15 likely likely RB cord-335975-m6lkrehi 751 16 underestimated underestimate VBN cord-335975-m6lkrehi 751 17 because because IN cord-335975-m6lkrehi 751 18 of of IN cord-335975-m6lkrehi 751 19 the the DT cord-335975-m6lkrehi 751 20 limited limited JJ cord-335975-m6lkrehi 751 21 performance performance NN cord-335975-m6lkrehi 751 22 of of IN cord-335975-m6lkrehi 751 23 the the DT cord-335975-m6lkrehi 751 24 conventional conventional JJ cord-335975-m6lkrehi 751 25 diagnostic diagnostic JJ cord-335975-m6lkrehi 751 26 tests test NNS cord-335975-m6lkrehi 751 27 . . . cord-335975-m6lkrehi 752 1 Multiplex multiplex JJ cord-335975-m6lkrehi 752 2 molecular molecular JJ cord-335975-m6lkrehi 752 3 diagnostic diagnostic JJ cord-335975-m6lkrehi 752 4 tests test NNS cord-335975-m6lkrehi 752 5 may may MD cord-335975-m6lkrehi 752 6 identify identify VB cord-335975-m6lkrehi 752 7 several several JJ cord-335975-m6lkrehi 752 8 pathogens pathogen NNS cord-335975-m6lkrehi 752 9 including include VBG cord-335975-m6lkrehi 752 10 viruses virus NNS cord-335975-m6lkrehi 752 11 and and CC cord-335975-m6lkrehi 752 12 bacteria bacteria NNS cord-335975-m6lkrehi 752 13 , , , cord-335975-m6lkrehi 752 14 from from IN cord-335975-m6lkrehi 752 15 a a DT cord-335975-m6lkrehi 752 16 single single JJ cord-335975-m6lkrehi 752 17 respiratory respiratory JJ cord-335975-m6lkrehi 752 18 tract tract NN cord-335975-m6lkrehi 752 19 sample sample NN cord-335975-m6lkrehi 752 20 , , , cord-335975-m6lkrehi 752 21 with with IN cord-335975-m6lkrehi 752 22 high high JJ cord-335975-m6lkrehi 752 23 sensitivity sensitivity NN cord-335975-m6lkrehi 752 24 . . . cord-335975-m6lkrehi 753 1 Using use VBG cord-335975-m6lkrehi 753 2 these these DT cord-335975-m6lkrehi 753 3 tests test NNS cord-335975-m6lkrehi 753 4 , , , cord-335975-m6lkrehi 753 5 respiratory respiratory JJ cord-335975-m6lkrehi 753 6 viruses virus NNS cord-335975-m6lkrehi 753 7 are be VBP cord-335975-m6lkrehi 753 8 identified identify VBN cord-335975-m6lkrehi 753 9 in in IN cord-335975-m6lkrehi 753 10 30 30 CD cord-335975-m6lkrehi 753 11 to to TO cord-335975-m6lkrehi 753 12 60 60 CD cord-335975-m6lkrehi 753 13 % % NN cord-335975-m6lkrehi 753 14 of of IN cord-335975-m6lkrehi 753 15 cases case NNS cord-335975-m6lkrehi 753 16 , , , cord-335975-m6lkrehi 753 17 according accord VBG cord-335975-m6lkrehi 753 18 to to IN cord-335975-m6lkrehi 753 19 the the DT cord-335975-m6lkrehi 753 20 series series NN cord-335975-m6lkrehi 753 21 . . . cord-335975-m6lkrehi 754 1 The the DT cord-335975-m6lkrehi 754 2 objective objective NN cord-335975-m6lkrehi 754 3 of of IN cord-335975-m6lkrehi 754 4 this this DT cord-335975-m6lkrehi 754 5 work work NN cord-335975-m6lkrehi 754 6 was be VBD cord-335975-m6lkrehi 754 7 to to TO cord-335975-m6lkrehi 754 8 describe describe VB cord-335975-m6lkrehi 754 9 the the DT cord-335975-m6lkrehi 754 10 microbial microbial JJ cord-335975-m6lkrehi 754 11 epidemiology epidemiology NN cord-335975-m6lkrehi 754 12 , , , cord-335975-m6lkrehi 754 13 the the DT cord-335975-m6lkrehi 754 14 management management NN cord-335975-m6lkrehi 754 15 and and CC cord-335975-m6lkrehi 754 16 the the DT cord-335975-m6lkrehi 754 17 outcome outcome NN cord-335975-m6lkrehi 754 18 of of IN cord-335975-m6lkrehi 754 19 patients patient NNS cord-335975-m6lkrehi 754 20 admitted admit VBN cord-335975-m6lkrehi 754 21 to to IN cord-335975-m6lkrehi 754 22 the the DT cord-335975-m6lkrehi 754 23 intensive intensive JJ cord-335975-m6lkrehi 754 24 care care NN cord-335975-m6lkrehi 754 25 unit unit NN cord-335975-m6lkrehi 754 26 ( ( -LRB- cord-335975-m6lkrehi 754 27 ICU ICU NNP cord-335975-m6lkrehi 754 28 ) ) -RRB- cord-335975-m6lkrehi 754 29 with with IN cord-335975-m6lkrehi 754 30 moderate moderate JJ cord-335975-m6lkrehi 754 31 to to IN cord-335975-m6lkrehi 754 32 severe severe JJ cord-335975-m6lkrehi 754 33 AECOPD AECOPD NNP cord-335975-m6lkrehi 754 34 , , , cord-335975-m6lkrehi 754 35 in in IN cord-335975-m6lkrehi 754 36 the the DT cord-335975-m6lkrehi 754 37 era era NN cord-335975-m6lkrehi 754 38 of of IN cord-335975-m6lkrehi 754 39 multiplex multiplex JJ cord-335975-m6lkrehi 754 40 testing testing NN cord-335975-m6lkrehi 754 41 . . . cord-335975-m6lkrehi 755 1 A a DT cord-335975-m6lkrehi 755 2 prospective prospective JJ cord-335975-m6lkrehi 755 3 non non AFX cord-335975-m6lkrehi 755 4 interventional interventional JJ cord-335975-m6lkrehi 755 5 multicenter multicenter JJ cord-335975-m6lkrehi 755 6 study study NN cord-335975-m6lkrehi 755 7 conducted conduct VBN cord-335975-m6lkrehi 755 8 in in IN cord-335975-m6lkrehi 755 9 two two CD cord-335975-m6lkrehi 755 10 university university NN cord-335975-m6lkrehi 755 11 - - HYPH cord-335975-m6lkrehi 755 12 teaching teach VBG cord-335975-m6lkrehi 755 13 hospitals hospital NNS cord-335975-m6lkrehi 755 14 . . . cord-335975-m6lkrehi 756 1 In in IN cord-335975-m6lkrehi 756 2 addition addition NN cord-335975-m6lkrehi 756 3 to to IN cord-335975-m6lkrehi 756 4 the the DT cord-335975-m6lkrehi 756 5 usual usual JJ cord-335975-m6lkrehi 756 6 samplings sampling NNS cord-335975-m6lkrehi 756 7 , , , cord-335975-m6lkrehi 756 8 a a DT cord-335975-m6lkrehi 756 9 nasopharyngeal nasopharyngeal JJ cord-335975-m6lkrehi 756 10 swab swab NN cord-335975-m6lkrehi 756 11 was be VBD cord-335975-m6lkrehi 756 12 performed perform VBN cord-335975-m6lkrehi 756 13 for for IN cord-335975-m6lkrehi 756 14 multiplex multiplex JJ cord-335975-m6lkrehi 756 15 polymerase polymerase NN cord-335975-m6lkrehi 756 16 chain chain NN cord-335975-m6lkrehi 756 17 reaction reaction NN cord-335975-m6lkrehi 756 18 ( ( -LRB- cord-335975-m6lkrehi 756 19 PCR PCR NNP cord-335975-m6lkrehi 756 20 ) ) -RRB- cord-335975-m6lkrehi 756 21 , , , cord-335975-m6lkrehi 756 22 using use VBG cord-335975-m6lkrehi 756 23 respiratory respiratory JJ cord-335975-m6lkrehi 756 24 panels panel NNS cord-335975-m6lkrehi 756 25 Fil Fil NNP cord-335975-m6lkrehi 756 26 - - HYPH cord-335975-m6lkrehi 756 27 mArray mArray NNP cord-335975-m6lkrehi 756 28 Biomérieux Biomérieux NNP cord-335975-m6lkrehi 756 29 ( ( -LRB- cord-335975-m6lkrehi 756 30 17 17 CD cord-335975-m6lkrehi 756 31 viruses virus NNS cord-335975-m6lkrehi 756 32 and and CC cord-335975-m6lkrehi 756 33 3 3 CD cord-335975-m6lkrehi 756 34 bacteria bacteria NNS cord-335975-m6lkrehi 756 35 ) ) -RRB- cord-335975-m6lkrehi 756 36 or or CC cord-335975-m6lkrehi 756 37 ePlex ePlex NNP cord-335975-m6lkrehi 756 38 automaton automaton NN cord-335975-m6lkrehi 756 39 ( ( -LRB- cord-335975-m6lkrehi 756 40 22 22 CD cord-335975-m6lkrehi 756 41 viruses virus NNS cord-335975-m6lkrehi 756 42 and and CC cord-335975-m6lkrehi 756 43 4 4 CD cord-335975-m6lkrehi 756 44 bacteria bacteria NNS cord-335975-m6lkrehi 756 45 ) ) -RRB- cord-335975-m6lkrehi 756 46 depending depend VBG cord-335975-m6lkrehi 756 47 on on IN cord-335975-m6lkrehi 756 48 the the DT cord-335975-m6lkrehi 756 49 center center NN cord-335975-m6lkrehi 756 50 . . . cord-335975-m6lkrehi 757 1 The the DT cord-335975-m6lkrehi 757 2 preliminary preliminary JJ cord-335975-m6lkrehi 757 3 results result NNS cord-335975-m6lkrehi 757 4 involve involve VBP cord-335975-m6lkrehi 757 5 the the DT cord-335975-m6lkrehi 757 6 37 37 CD cord-335975-m6lkrehi 757 7 patients patient NNS cord-335975-m6lkrehi 757 8 ( ( -LRB- cord-335975-m6lkrehi 757 9 29 29 CD cord-335975-m6lkrehi 757 10 males male NNS cord-335975-m6lkrehi 757 11 + + SYM cord-335975-m6lkrehi 757 12 70 70 CD cord-335975-m6lkrehi 757 13 years year NNS cord-335975-m6lkrehi 757 14 ( ( -LRB- cord-335975-m6lkrehi 757 15 55 55 CD cord-335975-m6lkrehi 757 16 - - SYM cord-335975-m6lkrehi 757 17 87 87 CD cord-335975-m6lkrehi 757 18 ) ) -RRB- cord-335975-m6lkrehi 757 19 ) ) -RRB- cord-335975-m6lkrehi 757 20 included include VBD cord-335975-m6lkrehi 757 21 in in IN cord-335975-m6lkrehi 757 22 Tenon Tenon NNP cord-335975-m6lkrehi 757 23 hospital hospital NN cord-335975-m6lkrehi 757 24 over over IN cord-335975-m6lkrehi 757 25 a a DT cord-335975-m6lkrehi 757 26 6-month 6-month CD cord-335975-m6lkrehi 757 27 period period NN cord-335975-m6lkrehi 757 28 . . . cord-335975-m6lkrehi 758 1 The the DT cord-335975-m6lkrehi 758 2 mean mean JJ cord-335975-m6lkrehi 758 3 FEV1 FEV1 NNP cord-335975-m6lkrehi 758 4 was be VBD cord-335975-m6lkrehi 758 5 37 37 CD cord-335975-m6lkrehi 758 6 % % NN cord-335975-m6lkrehi 758 7 ( ( -LRB- cord-335975-m6lkrehi 758 8 21 21 CD cord-335975-m6lkrehi 758 9 - - SYM cord-335975-m6lkrehi 758 10 60 60 CD cord-335975-m6lkrehi 758 11 ) ) -RRB- cord-335975-m6lkrehi 758 12 median median NN cord-335975-m6lkrehi 758 13 35 35 CD cord-335975-m6lkrehi 758 14 % % NN cord-335975-m6lkrehi 758 15 [ [ -LRB- cord-335975-m6lkrehi 758 16 31 31 CD cord-335975-m6lkrehi 758 17 ] ] -RRB- cord-335975-m6lkrehi 759 1 [ [ -LRB- cord-335975-m6lkrehi 759 2 32 32 CD cord-335975-m6lkrehi 759 3 ] ] -RRB- cord-335975-m6lkrehi 759 4 [ [ -LRB- cord-335975-m6lkrehi 759 5 33 33 CD cord-335975-m6lkrehi 759 6 ] ] -RRB- cord-335975-m6lkrehi 759 7 [ [ -LRB- cord-335975-m6lkrehi 759 8 34 34 CD cord-335975-m6lkrehi 759 9 ] ] -RRB- cord-335975-m6lkrehi 760 1 [ [ -LRB- cord-335975-m6lkrehi 760 2 35 35 CD cord-335975-m6lkrehi 760 3 ] ] -RRB- cord-335975-m6lkrehi 760 4 [ [ -LRB- cord-335975-m6lkrehi 760 5 36 36 CD cord-335975-m6lkrehi 760 6 ] ] -RRB- cord-335975-m6lkrehi 761 1 [ [ -LRB- cord-335975-m6lkrehi 761 2 37 37 CD cord-335975-m6lkrehi 761 3 ] ] -RRB- cord-335975-m6lkrehi 761 4 [ [ -LRB- cord-335975-m6lkrehi 761 5 38 38 CD cord-335975-m6lkrehi 761 6 ] ] -RRB- cord-335975-m6lkrehi 762 1 [ [ -LRB- cord-335975-m6lkrehi 762 2 39 39 CD cord-335975-m6lkrehi 762 3 ] ] -RRB- cord-335975-m6lkrehi 763 1 [ [ -LRB- cord-335975-m6lkrehi 763 2 40 40 CD cord-335975-m6lkrehi 763 3 ] ] -RRB- cord-335975-m6lkrehi 763 4 [ [ -LRB- cord-335975-m6lkrehi 763 5 41 41 CD cord-335975-m6lkrehi 763 6 ] ] -RRB- cord-335975-m6lkrehi 764 1 [ [ -LRB- cord-335975-m6lkrehi 764 2 42 42 CD cord-335975-m6lkrehi 764 3 ] ] -RRB- cord-335975-m6lkrehi 764 4 [ [ -LRB- cord-335975-m6lkrehi 764 5 43 43 CD cord-335975-m6lkrehi 764 6 ] ] -RRB- cord-335975-m6lkrehi 764 7 [ [ -LRB- cord-335975-m6lkrehi 764 8 44 44 CD cord-335975-m6lkrehi 764 9 ] ] -RRB- cord-335975-m6lkrehi 764 10 . . . cord-335975-m6lkrehi 765 1 Drug drug NN cord-335975-m6lkrehi 765 2 therapies therapy NNS cord-335975-m6lkrehi 765 3 included include VBD cord-335975-m6lkrehi 765 4 anticholinergics anticholinergic NNS cord-335975-m6lkrehi 765 5 ( ( -LRB- cord-335975-m6lkrehi 765 6 n n NN cord-335975-m6lkrehi 765 7 = = SYM cord-335975-m6lkrehi 765 8 21 21 CD cord-335975-m6lkrehi 765 9 + + SYM cord-335975-m6lkrehi 765 10 62 62 CD cord-335975-m6lkrehi 765 11 % % NN cord-335975-m6lkrehi 765 12 ) ) -RRB- cord-335975-m6lkrehi 765 13 and and CC cord-335975-m6lkrehi 765 14 beta-2-mimetics beta-2-mimetic NNS cord-335975-m6lkrehi 765 15 ( ( -LRB- cord-335975-m6lkrehi 765 16 n n NN cord-335975-m6lkrehi 765 17 = = SYM cord-335975-m6lkrehi 765 18 24 24 CD cord-335975-m6lkrehi 765 19 + + SYM cord-335975-m6lkrehi 765 20 71 71 CD cord-335975-m6lkrehi 765 21 % % NN cord-335975-m6lkrehi 765 22 ) ) -RRB- cord-335975-m6lkrehi 765 23 , , , cord-335975-m6lkrehi 765 24 inhaled inhale VBN cord-335975-m6lkrehi 765 25 ( ( -LRB- cord-335975-m6lkrehi 765 26 n n NN cord-335975-m6lkrehi 765 27 = = SYM cord-335975-m6lkrehi 765 28 16 16 CD cord-335975-m6lkrehi 765 29 + + SYM cord-335975-m6lkrehi 765 30 47 47 CD cord-335975-m6lkrehi 765 31 % % NN cord-335975-m6lkrehi 765 32 ) ) -RRB- cord-335975-m6lkrehi 765 33 or or CC cord-335975-m6lkrehi 765 34 oral oral JJ cord-335975-m6lkrehi 765 35 ( ( -LRB- cord-335975-m6lkrehi 765 36 n n NN cord-335975-m6lkrehi 765 37 = = SYM cord-335975-m6lkrehi 765 38 2 2 CD cord-335975-m6lkrehi 765 39 + + SYM cord-335975-m6lkrehi 765 40 6 6 CD cord-335975-m6lkrehi 765 41 % % NN cord-335975-m6lkrehi 765 42 ) ) -RRB- cord-335975-m6lkrehi 765 43 steroids steroid NNS cord-335975-m6lkrehi 765 44 , , , cord-335975-m6lkrehi 765 45 and and CC cord-335975-m6lkrehi 765 46 azithromycin azithromycin NN cord-335975-m6lkrehi 765 47 ( ( -LRB- cord-335975-m6lkrehi 765 48 n n NN cord-335975-m6lkrehi 765 49 = = SYM cord-335975-m6lkrehi 765 50 5 5 CD cord-335975-m6lkrehi 765 51 + + SYM cord-335975-m6lkrehi 765 52 23 23 CD cord-335975-m6lkrehi 765 53 % % NN cord-335975-m6lkrehi 765 54 ) ) -RRB- cord-335975-m6lkrehi 765 55 . . . cord-335975-m6lkrehi 766 1 A a DT cord-335975-m6lkrehi 766 2 respiratory respiratory JJ cord-335975-m6lkrehi 766 3 virus virus NN cord-335975-m6lkrehi 766 4 was be VBD cord-335975-m6lkrehi 766 5 identified identify VBN cord-335975-m6lkrehi 766 6 in in IN cord-335975-m6lkrehi 766 7 11 11 CD cord-335975-m6lkrehi 766 8 patients patient NNS cord-335975-m6lkrehi 766 9 ( ( -LRB- cord-335975-m6lkrehi 766 10 30 30 CD cord-335975-m6lkrehi 766 11 % % NN cord-335975-m6lkrehi 766 12 ) ) -RRB- cord-335975-m6lkrehi 766 13 , , , cord-335975-m6lkrehi 766 14 alone alone JJ cord-335975-m6lkrehi 766 15 or or CC cord-335975-m6lkrehi 766 16 in in IN cord-335975-m6lkrehi 766 17 combination combination NN cord-335975-m6lkrehi 766 18 with with IN cord-335975-m6lkrehi 766 19 a a DT cord-335975-m6lkrehi 766 20 bacterium bacterium NN cord-335975-m6lkrehi 766 21 ( ( -LRB- cord-335975-m6lkrehi 766 22 n n NN cord-335975-m6lkrehi 766 23 = = SYM cord-335975-m6lkrehi 766 24 6 6 CD cord-335975-m6lkrehi 766 25 ) ) -RRB- cord-335975-m6lkrehi 766 26 . . . cord-335975-m6lkrehi 767 1 A a DT cord-335975-m6lkrehi 767 2 bacterial bacterial JJ cord-335975-m6lkrehi 767 3 pathogen pathogen NN cord-335975-m6lkrehi 767 4 was be VBD cord-335975-m6lkrehi 767 5 identified identify VBN cord-335975-m6lkrehi 767 6 alone alone RB cord-335975-m6lkrehi 767 7 9 9 CD cord-335975-m6lkrehi 767 8 times time NNS cord-335975-m6lkrehi 767 9 ( ( -LRB- cord-335975-m6lkrehi 767 10 21 21 CD cord-335975-m6lkrehi 767 11 % % NN cord-335975-m6lkrehi 767 12 ) ) -RRB- cord-335975-m6lkrehi 767 13 . . . cord-335975-m6lkrehi 768 1 Therapeutic therapeutic JJ cord-335975-m6lkrehi 768 2 interventions intervention NNS cord-335975-m6lkrehi 768 3 did do VBD cord-335975-m6lkrehi 768 4 not not RB cord-335975-m6lkrehi 768 5 differ differ VB cord-335975-m6lkrehi 768 6 depending depend VBG cord-335975-m6lkrehi 768 7 on on IN cord-335975-m6lkrehi 768 8 whether whether IN cord-335975-m6lkrehi 768 9 a a DT cord-335975-m6lkrehi 768 10 virus virus NN cord-335975-m6lkrehi 768 11 was be VBD cord-335975-m6lkrehi 768 12 detected detect VBN cord-335975-m6lkrehi 768 13 or or CC cord-335975-m6lkrehi 768 14 not not RB cord-335975-m6lkrehi 768 15 - - HYPH cord-335975-m6lkrehi 768 16 exposure exposure NN cord-335975-m6lkrehi 768 17 to to IN cord-335975-m6lkrehi 768 18 antibiotics antibiotic NNS cord-335975-m6lkrehi 768 19 ( ( -LRB- cord-335975-m6lkrehi 768 20 10 10 CD cord-335975-m6lkrehi 768 21 ± ± CD cord-335975-m6lkrehi 768 22 1.8 1.8 CD cord-335975-m6lkrehi 768 23 vs. vs. IN cord-335975-m6lkrehi 768 24 12.5 12.5 CD cord-335975-m6lkrehi 768 25 ± ± CD cord-335975-m6lkrehi 768 26 2 2 CD cord-335975-m6lkrehi 768 27 d d NN cord-335975-m6lkrehi 768 28 + + CC cord-335975-m6lkrehi 768 29 p p NN cord-335975-m6lkrehi 768 30 = = SYM cord-335975-m6lkrehi 768 31 0.4 0.4 CD cord-335975-m6lkrehi 768 32 ) ) -RRB- cord-335975-m6lkrehi 768 33 , , , cord-335975-m6lkrehi 768 34 administration administration NN cord-335975-m6lkrehi 768 35 of of IN cord-335975-m6lkrehi 768 36 oseltamivir oseltamivir NNP cord-335975-m6lkrehi 768 37 ( ( -LRB- cord-335975-m6lkrehi 768 38 5/6 5/6 CD cord-335975-m6lkrehi 768 39 vs. vs. IN cord-335975-m6lkrehi 768 40 8/18 8/18 CD cord-335975-m6lkrehi 769 1 + + CC cord-335975-m6lkrehi 769 2 p p NN cord-335975-m6lkrehi 769 3 = = SYM cord-335975-m6lkrehi 769 4 0.39 0.39 CD cord-335975-m6lkrehi 769 5 ) ) -RRB- cord-335975-m6lkrehi 769 6 , , , cord-335975-m6lkrehi 769 7 steroids steroid NNS cord-335975-m6lkrehi 769 8 ( ( -LRB- cord-335975-m6lkrehi 769 9 1/7 1/7 CD cord-335975-m6lkrehi 769 10 vs. vs. NN cord-335975-m6lkrehi 769 11 3/15 3/15 CD cord-335975-m6lkrehi 769 12 + + SYM cord-335975-m6lkrehi 769 13 p p NN cord-335975-m6lkrehi 769 14 = = SYM cord-335975-m6lkrehi 769 15 0.12 0.12 CD cord-335975-m6lkrehi 769 16 ) ) -RRB- cord-335975-m6lkrehi 769 17 and and CC cord-335975-m6lkrehi 769 18 mechanical mechanical JJ cord-335975-m6lkrehi 769 19 ventilation ventilation NN cord-335975-m6lkrehi 769 20 ( ( -LRB- cord-335975-m6lkrehi 769 21 11/11 11/11 CD cord-335975-m6lkrehi 769 22 vs. vs. IN cord-335975-m6lkrehi 769 23 20/26 20/26 CD cord-335975-m6lkrehi 769 24 + + CC cord-335975-m6lkrehi 769 25 p p NN cord-335975-m6lkrehi 769 26 = = NN cord-335975-m6lkrehi 769 27 .08 .08 CD cord-335975-m6lkrehi 769 28 ) ) -RRB- cord-335975-m6lkrehi 769 29 . . . cord-335975-m6lkrehi 770 1 The the DT cord-335975-m6lkrehi 770 2 ICU ICU NNP cord-335975-m6lkrehi 770 3 length length NN cord-335975-m6lkrehi 770 4 of of IN cord-335975-m6lkrehi 770 5 stay stay NN cord-335975-m6lkrehi 770 6 ( ( -LRB- cord-335975-m6lkrehi 770 7 5.8 5.8 CD cord-335975-m6lkrehi 770 8 ± ± CD cord-335975-m6lkrehi 770 9 0.8 0.8 CD cord-335975-m6lkrehi 770 10 vs. vs. NN cord-335975-m6lkrehi 770 11 7.8 7.8 CD cord-335975-m6lkrehi 770 12 ± ± CD cord-335975-m6lkrehi 770 13 1.1 1.1 CD cord-335975-m6lkrehi 770 14 d d NN cord-335975-m6lkrehi 770 15 + + CC cord-335975-m6lkrehi 770 16 p p NN cord-335975-m6lkrehi 770 17 = = SYM cord-335975-m6lkrehi 770 18 0.29 0.29 CD cord-335975-m6lkrehi 770 19 ) ) -RRB- cord-335975-m6lkrehi 770 20 was be VBD cord-335975-m6lkrehi 770 21 similar similar JJ cord-335975-m6lkrehi 770 22 . . . cord-335975-m6lkrehi 771 1 The the DT cord-335975-m6lkrehi 771 2 ICU ICU NNP cord-335975-m6lkrehi 771 3 and and CC cord-335975-m6lkrehi 771 4 90d 90d CD cord-335975-m6lkrehi 771 5 - - HYPH cord-335975-m6lkrehi 771 6 mortality mortality NN cord-335975-m6lkrehi 771 7 rates rate NNS cord-335975-m6lkrehi 771 8 were be VBD cord-335975-m6lkrehi 771 9 5.4 5.4 CD cord-335975-m6lkrehi 771 10 and and CC cord-335975-m6lkrehi 771 11 13.5 13.5 CD cord-335975-m6lkrehi 771 12 % % NN cord-335975-m6lkrehi 771 13 , , , cord-335975-m6lkrehi 771 14 respectively respectively RB cord-335975-m6lkrehi 771 15 . . . cord-335975-m6lkrehi 772 1 Conclusion conclusion NN cord-335975-m6lkrehi 772 2 : : : cord-335975-m6lkrehi 773 1 Respiratory respiratory JJ cord-335975-m6lkrehi 773 2 viruses virus NNS cord-335975-m6lkrehi 773 3 are be VBP cord-335975-m6lkrehi 773 4 frequently frequently RB cord-335975-m6lkrehi 773 5 involved involve VBN cord-335975-m6lkrehi 773 6 in in IN cord-335975-m6lkrehi 773 7 moderate moderate JJ cord-335975-m6lkrehi 773 8 to to IN cord-335975-m6lkrehi 773 9 severe severe JJ cord-335975-m6lkrehi 773 10 AECOPD aecopd NN cord-335975-m6lkrehi 773 11 . . . cord-335975-m6lkrehi 774 1 The the DT cord-335975-m6lkrehi 774 2 respiratory respiratory JJ cord-335975-m6lkrehi 774 3 multiplex multiplex NN cord-335975-m6lkrehi 774 4 PCR pcr NN cord-335975-m6lkrehi 774 5 should should MD cord-335975-m6lkrehi 774 6 be be VB cord-335975-m6lkrehi 774 7 performed perform VBN cord-335975-m6lkrehi 774 8 in in IN cord-335975-m6lkrehi 774 9 this this DT cord-335975-m6lkrehi 774 10 setting setting NN cord-335975-m6lkrehi 774 11 and and CC cord-335975-m6lkrehi 774 12 the the DT cord-335975-m6lkrehi 774 13 results result NNS cord-335975-m6lkrehi 774 14 should should MD cord-335975-m6lkrehi 774 15 be be VB cord-335975-m6lkrehi 774 16 taken take VBN cord-335975-m6lkrehi 774 17 into into IN cord-335975-m6lkrehi 774 18 account account NN cord-335975-m6lkrehi 774 19 to to IN cord-335975-m6lkrehi 774 20 more more RBR cord-335975-m6lkrehi 774 21 adequately adequately RB cord-335975-m6lkrehi 774 22 use use VB cord-335975-m6lkrehi 774 23 the the DT cord-335975-m6lkrehi 774 24 anti anti JJ cord-335975-m6lkrehi 774 25 - - JJ cord-335975-m6lkrehi 774 26 microbial microbial JJ cord-335975-m6lkrehi 774 27 treatments treatment NNS cord-335975-m6lkrehi 774 28 . . . cord-335975-m6lkrehi 775 1 Introduction introduction NN cord-335975-m6lkrehi 775 2 : : : cord-335975-m6lkrehi 775 3 Prophylactic prophylactic JJ cord-335975-m6lkrehi 775 4 non non JJ cord-335975-m6lkrehi 775 5 - - JJ cord-335975-m6lkrehi 775 6 invasive invasive JJ cord-335975-m6lkrehi 775 7 ventilation ventilation NN cord-335975-m6lkrehi 775 8 ( ( -LRB- cord-335975-m6lkrehi 775 9 NIV NIV NNP cord-335975-m6lkrehi 775 10 ) ) -RRB- cord-335975-m6lkrehi 775 11 is be VBZ cord-335975-m6lkrehi 775 12 a a DT cord-335975-m6lkrehi 775 13 well well RB cord-335975-m6lkrehi 775 14 established establish VBN cord-335975-m6lkrehi 775 15 method method NN cord-335975-m6lkrehi 775 16 for for IN cord-335975-m6lkrehi 775 17 prevention prevention NN cord-335975-m6lkrehi 775 18 of of IN cord-335975-m6lkrehi 775 19 post post JJ cord-335975-m6lkrehi 775 20 - - JJ cord-335975-m6lkrehi 775 21 extubation extubation JJ cord-335975-m6lkrehi 775 22 acute acute JJ cord-335975-m6lkrehi 775 23 respiratory respiratory JJ cord-335975-m6lkrehi 775 24 failure failure NN cord-335975-m6lkrehi 775 25 in in IN cord-335975-m6lkrehi 775 26 hypercapnic hypercapnic NNP cord-335975-m6lkrehi 775 27 patients patient NNS cord-335975-m6lkrehi 775 28 . . . cord-335975-m6lkrehi 776 1 However however RB cord-335975-m6lkrehi 776 2 , , , cord-335975-m6lkrehi 776 3 its -PRON- PRP$ cord-335975-m6lkrehi 776 4 role role NN cord-335975-m6lkrehi 776 5 in in IN cord-335975-m6lkrehi 776 6 the the DT cord-335975-m6lkrehi 776 7 postextubation postextubation NN cord-335975-m6lkrehi 776 8 period period NN cord-335975-m6lkrehi 776 9 , , , cord-335975-m6lkrehi 776 10 in in IN cord-335975-m6lkrehi 776 11 traumatic traumatic JJ cord-335975-m6lkrehi 776 12 brain brain NN cord-335975-m6lkrehi 776 13 injury injury NN cord-335975-m6lkrehi 776 14 patients patient NNS cord-335975-m6lkrehi 776 15 , , , cord-335975-m6lkrehi 776 16 is be VBZ cord-335975-m6lkrehi 776 17 uncertain uncertain JJ cord-335975-m6lkrehi 776 18 . . . cord-335975-m6lkrehi 777 1 Especially especially RB cord-335975-m6lkrehi 777 2 , , , cord-335975-m6lkrehi 777 3 because because IN cord-335975-m6lkrehi 777 4 of of IN cord-335975-m6lkrehi 777 5 effects effect NNS cord-335975-m6lkrehi 777 6 of of IN cord-335975-m6lkrehi 777 7 the the DT cord-335975-m6lkrehi 777 8 brain brain NN cord-335975-m6lkrehi 777 9 injury injury NN cord-335975-m6lkrehi 777 10 , , , cord-335975-m6lkrehi 777 11 on on IN cord-335975-m6lkrehi 777 12 respiration respiration NN cord-335975-m6lkrehi 777 13 and and CC cord-335975-m6lkrehi 777 14 airway airway NN cord-335975-m6lkrehi 777 15 control control NN cord-335975-m6lkrehi 777 16 . . . cord-335975-m6lkrehi 778 1 We -PRON- PRP cord-335975-m6lkrehi 778 2 perform perform VBP cord-335975-m6lkrehi 778 3 a a DT cord-335975-m6lkrehi 778 4 study study NN cord-335975-m6lkrehi 778 5 to to TO cord-335975-m6lkrehi 778 6 assess assess VB cord-335975-m6lkrehi 778 7 the the DT cord-335975-m6lkrehi 778 8 impact impact NN cord-335975-m6lkrehi 778 9 of of IN cord-335975-m6lkrehi 778 10 prophylactic prophylactic JJ cord-335975-m6lkrehi 778 11 NIV NIV NNP cord-335975-m6lkrehi 778 12 after after IN cord-335975-m6lkrehi 778 13 extubation extubation NN cord-335975-m6lkrehi 778 14 among among IN cord-335975-m6lkrehi 778 15 patients patient NNS cord-335975-m6lkrehi 778 16 with with IN cord-335975-m6lkrehi 778 17 severe severe JJ cord-335975-m6lkrehi 778 18 traumatic traumatic JJ cord-335975-m6lkrehi 778 19 brain brain NN cord-335975-m6lkrehi 778 20 injury injury NN cord-335975-m6lkrehi 778 21 . . . cord-335975-m6lkrehi 779 1 Patients patient NNS cord-335975-m6lkrehi 779 2 and and CC cord-335975-m6lkrehi 779 3 methods method NNS cord-335975-m6lkrehi 779 4 : : : cord-335975-m6lkrehi 779 5 Over over IN cord-335975-m6lkrehi 779 6 a a DT cord-335975-m6lkrehi 779 7 period period NN cord-335975-m6lkrehi 779 8 of of IN cord-335975-m6lkrehi 779 9 1 1 CD cord-335975-m6lkrehi 779 10 year year NN cord-335975-m6lkrehi 779 11 , , , cord-335975-m6lkrehi 779 12 adult adult NN cord-335975-m6lkrehi 779 13 patients patient NNS cord-335975-m6lkrehi 779 14 with with IN cord-335975-m6lkrehi 779 15 isolated isolate VBN cord-335975-m6lkrehi 779 16 severe severe JJ cord-335975-m6lkrehi 779 17 traumatic traumatic JJ cord-335975-m6lkrehi 779 18 brain brain NN cord-335975-m6lkrehi 779 19 injury injury NN cord-335975-m6lkrehi 779 20 , , , cord-335975-m6lkrehi 779 21 who who WP cord-335975-m6lkrehi 779 22 were be VBD cord-335975-m6lkrehi 779 23 under under IN cord-335975-m6lkrehi 779 24 invasive invasive JJ cord-335975-m6lkrehi 779 25 mechanical mechanical JJ cord-335975-m6lkrehi 779 26 ventilation ventilation NN cord-335975-m6lkrehi 779 27 for for IN cord-335975-m6lkrehi 779 28 more more JJR cord-335975-m6lkrehi 779 29 than than IN cord-335975-m6lkrehi 779 30 48 48 CD cord-335975-m6lkrehi 779 31 h h NN cord-335975-m6lkrehi 779 32 were be VBD cord-335975-m6lkrehi 779 33 eligible eligible JJ cord-335975-m6lkrehi 779 34 for for IN cord-335975-m6lkrehi 779 35 inclusion inclusion NN cord-335975-m6lkrehi 779 36 in in IN cord-335975-m6lkrehi 779 37 the the DT cord-335975-m6lkrehi 779 38 study study NN cord-335975-m6lkrehi 779 39 . . . cord-335975-m6lkrehi 780 1 They -PRON- PRP cord-335975-m6lkrehi 780 2 were be VBD cord-335975-m6lkrehi 780 3 randomized randomize VBN cord-335975-m6lkrehi 780 4 , , , cord-335975-m6lkrehi 780 5 after after IN cord-335975-m6lkrehi 780 6 decision decision NN cord-335975-m6lkrehi 780 7 of of IN cord-335975-m6lkrehi 780 8 extubation extubation NN cord-335975-m6lkrehi 780 9 , , , cord-335975-m6lkrehi 780 10 to to TO cord-335975-m6lkrehi 780 11 receive receive VB cord-335975-m6lkrehi 780 12 conventional conventional JJ cord-335975-m6lkrehi 780 13 therapy therapy NN cord-335975-m6lkrehi 780 14 or or CC cord-335975-m6lkrehi 780 15 conventional conventional JJ cord-335975-m6lkrehi 780 16 therapy therapy NN cord-335975-m6lkrehi 780 17 associated associate VBN cord-335975-m6lkrehi 780 18 with with IN cord-335975-m6lkrehi 780 19 NIV NIV NNP cord-335975-m6lkrehi 780 20 . . . cord-335975-m6lkrehi 781 1 Conventional conventional JJ cord-335975-m6lkrehi 781 2 therapy therapy NN cord-335975-m6lkrehi 781 3 consisted consist VBD cord-335975-m6lkrehi 781 4 of of IN cord-335975-m6lkrehi 781 5 oxygen oxygen NN cord-335975-m6lkrehi 781 6 delivery delivery NN cord-335975-m6lkrehi 781 7 by by IN cord-335975-m6lkrehi 781 8 facial facial JJ cord-335975-m6lkrehi 781 9 mask mask NN cord-335975-m6lkrehi 781 10 , , , cord-335975-m6lkrehi 781 11 semi semi JJ cord-335975-m6lkrehi 781 12 - - JJ cord-335975-m6lkrehi 781 13 recumbent recumbent JJ cord-335975-m6lkrehi 781 14 position position NN cord-335975-m6lkrehi 781 15 , , , cord-335975-m6lkrehi 781 16 mucus mucus NN cord-335975-m6lkrehi 781 17 suctioning suctioning NN cord-335975-m6lkrehi 781 18 and and CC cord-335975-m6lkrehi 781 19 nebulization nebulization NN cord-335975-m6lkrehi 781 20 therapy therapy NN cord-335975-m6lkrehi 781 21 . . . cord-335975-m6lkrehi 782 1 The the DT cord-335975-m6lkrehi 782 2 main main JJ cord-335975-m6lkrehi 782 3 objective objective NN cord-335975-m6lkrehi 782 4 of of IN cord-335975-m6lkrehi 782 5 the the DT cord-335975-m6lkrehi 782 6 study study NN cord-335975-m6lkrehi 782 7 is be VBZ cord-335975-m6lkrehi 782 8 to to TO cord-335975-m6lkrehi 782 9 assess assess VB cord-335975-m6lkrehi 782 10 the the DT cord-335975-m6lkrehi 782 11 impact impact NN cord-335975-m6lkrehi 782 12 on on IN cord-335975-m6lkrehi 782 13 reintubation reintubation NN cord-335975-m6lkrehi 782 14 rate rate NN cord-335975-m6lkrehi 782 15 . . . cord-335975-m6lkrehi 783 1 Extubation Extubation NNP cord-335975-m6lkrehi 783 2 succes succes NN cord-335975-m6lkrehi 783 3 was be VBD cord-335975-m6lkrehi 783 4 defined define VBN cord-335975-m6lkrehi 783 5 by by IN cord-335975-m6lkrehi 783 6 the the DT cord-335975-m6lkrehi 783 7 absence absence NN cord-335975-m6lkrehi 783 8 of of IN cord-335975-m6lkrehi 783 9 need need NN cord-335975-m6lkrehi 783 10 for for IN cord-335975-m6lkrehi 783 11 reintubation reintubation NN cord-335975-m6lkrehi 783 12 within within IN cord-335975-m6lkrehi 783 13 the the DT cord-335975-m6lkrehi 783 14 7 7 CD cord-335975-m6lkrehi 783 15 days day NNS cord-335975-m6lkrehi 783 16 . . . cord-335975-m6lkrehi 784 1 The the DT cord-335975-m6lkrehi 784 2 secondary secondary JJ cord-335975-m6lkrehi 784 3 objective objective NN cord-335975-m6lkrehi 784 4 is be VBZ cord-335975-m6lkrehi 784 5 to to TO cord-335975-m6lkrehi 784 6 evaluate evaluate VB cord-335975-m6lkrehi 784 7 the the DT cord-335975-m6lkrehi 784 8 effect effect NN cord-335975-m6lkrehi 784 9 on on IN cord-335975-m6lkrehi 784 10 ICU ICU NNP cord-335975-m6lkrehi 784 11 length length NN cord-335975-m6lkrehi 784 12 of of IN cord-335975-m6lkrehi 784 13 stay stay NN cord-335975-m6lkrehi 784 14 after after IN cord-335975-m6lkrehi 784 15 extubation extubation NN cord-335975-m6lkrehi 784 16 . . . cord-335975-m6lkrehi 785 1 The the DT cord-335975-m6lkrehi 785 2 clinical clinical JJ cord-335975-m6lkrehi 785 3 benefit benefit NN cord-335975-m6lkrehi 785 4 of of IN cord-335975-m6lkrehi 785 5 non non JJ cord-335975-m6lkrehi 785 6 - - JJ cord-335975-m6lkrehi 785 7 invasive invasive JJ cord-335975-m6lkrehi 785 8 ventilation ventilation NN cord-335975-m6lkrehi 785 9 ( ( -LRB- cord-335975-m6lkrehi 785 10 NIV NIV NNP cord-335975-m6lkrehi 785 11 ) ) -RRB- cord-335975-m6lkrehi 785 12 in in IN cord-335975-m6lkrehi 785 13 patients patient NNS cord-335975-m6lkrehi 785 14 with with IN cord-335975-m6lkrehi 785 15 acute acute JJ cord-335975-m6lkrehi 785 16 hypoxemic hypoxemic JJ cord-335975-m6lkrehi 785 17 respiratory respiratory JJ cord-335975-m6lkrehi 785 18 failure failure NN cord-335975-m6lkrehi 785 19 ( ( -LRB- cord-335975-m6lkrehi 785 20 ARF ARF NNP cord-335975-m6lkrehi 785 21 ) ) -RRB- cord-335975-m6lkrehi 785 22 is be VBZ cord-335975-m6lkrehi 785 23 being be VBG cord-335975-m6lkrehi 785 24 called call VBN cord-335975-m6lkrehi 785 25 into into IN cord-335975-m6lkrehi 785 26 question question NN cord-335975-m6lkrehi 785 27 . . . cord-335975-m6lkrehi 786 1 Indeed indeed RB cord-335975-m6lkrehi 786 2 , , , cord-335975-m6lkrehi 786 3 in in IN cord-335975-m6lkrehi 786 4 a a DT cord-335975-m6lkrehi 786 5 multicenter multicenter JJ cord-335975-m6lkrehi 786 6 randomized randomized JJ cord-335975-m6lkrehi 786 7 trial trial NN cord-335975-m6lkrehi 786 8 recently recently RB cord-335975-m6lkrehi 786 9 conducted conduct VBN cord-335975-m6lkrehi 786 10 in in IN cord-335975-m6lkrehi 786 11 hypoxemic hypoxemic JJ cord-335975-m6lkrehi 786 12 ARF ARF NNP cord-335975-m6lkrehi 786 13 patients patient NNS cord-335975-m6lkrehi 786 14 ( ( -LRB- cord-335975-m6lkrehi 786 15 Pa02 Pa02 NNP cord-335975-m6lkrehi 786 16 Fi02 Fi02 NNP cord-335975-m6lkrehi 786 17 < < XX cord-335975-m6lkrehi 786 18 300 300 CD cord-335975-m6lkrehi 786 19 ) ) -RRB- cord-335975-m6lkrehi 786 20 , , , cord-335975-m6lkrehi 786 21 intubation intubation NN cord-335975-m6lkrehi 786 22 rate rate NN cord-335975-m6lkrehi 786 23 in in IN cord-335975-m6lkrehi 786 24 the the DT cord-335975-m6lkrehi 786 25 NIV NIV NNP cord-335975-m6lkrehi 786 26 group group NN cord-335975-m6lkrehi 786 27 was be VBD cord-335975-m6lkrehi 786 28 50 50 CD cord-335975-m6lkrehi 786 29 % % NN cord-335975-m6lkrehi 786 30 and and CC cord-335975-m6lkrehi 786 31 intensive intensive JJ cord-335975-m6lkrehi 786 32 care care NN cord-335975-m6lkrehi 786 33 unit unit NN cord-335975-m6lkrehi 787 1 ( ( -LRB- cord-335975-m6lkrehi 787 2 ICU ICU NNP cord-335975-m6lkrehi 787 3 ) ) -RRB- cord-335975-m6lkrehi 787 4 mortality mortality NN cord-335975-m6lkrehi 787 5 rate rate NN cord-335975-m6lkrehi 787 6 was be VBD cord-335975-m6lkrehi 787 7 25 25 CD cord-335975-m6lkrehi 787 8 % % NN cord-335975-m6lkrehi 787 9 , , , cord-335975-m6lkrehi 787 10 numbers number NNS cord-335975-m6lkrehi 787 11 higher high JJR cord-335975-m6lkrehi 787 12 than than IN cord-335975-m6lkrehi 787 13 in in IN cord-335975-m6lkrehi 787 14 the the DT cord-335975-m6lkrehi 787 15 standard standard JJ cord-335975-m6lkrehi 787 16 - - HYPH cord-335975-m6lkrehi 787 17 oxygen oxygen NN cord-335975-m6lkrehi 787 18 group group NN cord-335975-m6lkrehi 787 19 ( ( -LRB- cord-335975-m6lkrehi 787 20 1 1 CD cord-335975-m6lkrehi 787 21 ) ) -RRB- cord-335975-m6lkrehi 787 22 . . . cord-335975-m6lkrehi 788 1 An an DT cord-335975-m6lkrehi 788 2 excessive excessive JJ cord-335975-m6lkrehi 788 3 tidal tidal JJ cord-335975-m6lkrehi 788 4 volume volume NN cord-335975-m6lkrehi 788 5 under under IN cord-335975-m6lkrehi 788 6 NIV NIV NNP cord-335975-m6lkrehi 788 7 is be VBZ cord-335975-m6lkrehi 788 8 a a DT cord-335975-m6lkrehi 788 9 hypothesis hypothesis NN cord-335975-m6lkrehi 788 10 to to TO cord-335975-m6lkrehi 788 11 explain explain VB cord-335975-m6lkrehi 788 12 these these DT cord-335975-m6lkrehi 788 13 bad bad JJ cord-335975-m6lkrehi 788 14 outcomes outcome NNS cord-335975-m6lkrehi 788 15 ( ( -LRB- cord-335975-m6lkrehi 788 16 2 2 CD cord-335975-m6lkrehi 788 17 ) ) -RRB- cord-335975-m6lkrehi 788 18 . . . cord-335975-m6lkrehi 789 1 Our -PRON- PRP$ cord-335975-m6lkrehi 789 2 experience experience NN cord-335975-m6lkrehi 789 3 does do VBZ cord-335975-m6lkrehi 789 4 not not RB cord-335975-m6lkrehi 789 5 seem seem VB cord-335975-m6lkrehi 789 6 to to TO cord-335975-m6lkrehi 789 7 support support VB cord-335975-m6lkrehi 789 8 these these DT cord-335975-m6lkrehi 789 9 data datum NNS cord-335975-m6lkrehi 789 10 . . . cord-335975-m6lkrehi 790 1 Therefore therefore RB cord-335975-m6lkrehi 790 2 we -PRON- PRP cord-335975-m6lkrehi 790 3 wanted want VBD cord-335975-m6lkrehi 790 4 to to TO cord-335975-m6lkrehi 790 5 - - : cord-335975-m6lkrehi 790 6 investigate investigate VB cord-335975-m6lkrehi 790 7 the the DT cord-335975-m6lkrehi 790 8 rate rate NN cord-335975-m6lkrehi 790 9 of of IN cord-335975-m6lkrehi 790 10 NIV NIV NNP cord-335975-m6lkrehi 790 11 success success NN cord-335975-m6lkrehi 790 12 in in IN cord-335975-m6lkrehi 790 13 hypoxemic hypoxemic JJ cord-335975-m6lkrehi 790 14 ARF ARF NNP cord-335975-m6lkrehi 790 15 and and CC cord-335975-m6lkrehi 790 16 global global JJ cord-335975-m6lkrehi 790 17 in in IN cord-335975-m6lkrehi 790 18 - - HYPH cord-335975-m6lkrehi 790 19 ICU ICU NNP cord-335975-m6lkrehi 790 20 mortality mortality NN cord-335975-m6lkrehi 790 21 . . . cord-335975-m6lkrehi 791 1 Estimate estimate VB cord-335975-m6lkrehi 791 2 the the DT cord-335975-m6lkrehi 791 3 average average JJ cord-335975-m6lkrehi 791 4 expired expire VBD cord-335975-m6lkrehi 791 5 tidal tidal JJ cord-335975-m6lkrehi 791 6 volume volume NN cord-335975-m6lkrehi 791 7 and and CC cord-335975-m6lkrehi 791 8 identify identify VB cord-335975-m6lkrehi 791 9 predictive predictive JJ cord-335975-m6lkrehi 791 10 factors factor NNS cord-335975-m6lkrehi 791 11 of of IN cord-335975-m6lkrehi 791 12 NIV NIV NNP cord-335975-m6lkrehi 791 13 failure failure NN cord-335975-m6lkrehi 791 14 . . . cord-335975-m6lkrehi 792 1 Conclusion conclusion NN cord-335975-m6lkrehi 792 2 : : : cord-335975-m6lkrehi 793 1 Though though IN cord-335975-m6lkrehi 793 2 limited limit VBN cord-335975-m6lkrehi 793 3 by by IN cord-335975-m6lkrehi 793 4 its -PRON- PRP$ cord-335975-m6lkrehi 793 5 design design NN cord-335975-m6lkrehi 793 6 , , , cord-335975-m6lkrehi 793 7 our -PRON- PRP$ cord-335975-m6lkrehi 793 8 study study NN cord-335975-m6lkrehi 793 9 seems seem VBZ cord-335975-m6lkrehi 793 10 to to TO cord-335975-m6lkrehi 793 11 show show VB cord-335975-m6lkrehi 793 12 a a DT cord-335975-m6lkrehi 793 13 similar similar JJ cord-335975-m6lkrehi 793 14 efficacy efficacy NN cord-335975-m6lkrehi 793 15 of of IN cord-335975-m6lkrehi 793 16 NIV NIV NNP cord-335975-m6lkrehi 793 17 following follow VBG cord-335975-m6lkrehi 793 18 UE UE NNP cord-335975-m6lkrehi 793 19 as as IN cord-335975-m6lkrehi 793 20 compared compare VBN cord-335975-m6lkrehi 793 21 to to IN cord-335975-m6lkrehi 793 22 planned plan VBN cord-335975-m6lkrehi 793 23 extubation extubation NN cord-335975-m6lkrehi 793 24 , , , cord-335975-m6lkrehi 793 25 with with IN cord-335975-m6lkrehi 793 26 a a DT cord-335975-m6lkrehi 793 27 safety safety NN cord-335975-m6lkrehi 793 28 concern concern NN cord-335975-m6lkrehi 793 29 for for IN cord-335975-m6lkrehi 793 30 rescue rescue NN cord-335975-m6lkrehi 793 31 NIV NIV NNP cord-335975-m6lkrehi 793 32 and and CC cord-335975-m6lkrehi 793 33 a a DT cord-335975-m6lkrehi 793 34 potential potential JJ cord-335975-m6lkrehi 793 35 interest interest NN cord-335975-m6lkrehi 793 36 for for IN cord-335975-m6lkrehi 793 37 " " `` cord-335975-m6lkrehi 793 38 prophylactic prophylactic JJ cord-335975-m6lkrehi 793 39 " " '' cord-335975-m6lkrehi 793 40 NIV NIV NNP cord-335975-m6lkrehi 793 41 . . . cord-335975-m6lkrehi 794 1 Further further JJ cord-335975-m6lkrehi 794 2 data datum NNS cord-335975-m6lkrehi 794 3 is be VBZ cord-335975-m6lkrehi 794 4 warranted warrant VBN cord-335975-m6lkrehi 794 5 . . . cord-335975-m6lkrehi 795 1 which which WDT cord-335975-m6lkrehi 795 2 is be VBZ cord-335975-m6lkrehi 795 3 yet yet RB cord-335975-m6lkrehi 795 4 operator operator NN cord-335975-m6lkrehi 795 5 dependent dependent JJ cord-335975-m6lkrehi 795 6 and and CC cord-335975-m6lkrehi 795 7 time time NN cord-335975-m6lkrehi 795 8 - - HYPH cord-335975-m6lkrehi 795 9 consuming consume VBG cord-335975-m6lkrehi 795 10 , , , cord-335975-m6lkrehi 795 11 or or CC cord-335975-m6lkrehi 795 12 by by IN cord-335975-m6lkrehi 795 13 invasive invasive JJ cord-335975-m6lkrehi 795 14 methods method NNS cord-335975-m6lkrehi 795 15 including include VBG cord-335975-m6lkrehi 795 16 esophageal esophageal JJ cord-335975-m6lkrehi 795 17 pressure pressure NN cord-335975-m6lkrehi 795 18 or or CC cord-335975-m6lkrehi 795 19 diaphragmatic diaphragmatic JJ cord-335975-m6lkrehi 795 20 electromyogram electromyogram JJ cord-335975-m6lkrehi 795 21 measurements measurement NNS cord-335975-m6lkrehi 795 22 . . . cord-335975-m6lkrehi 796 1 The the DT cord-335975-m6lkrehi 796 2 main main JJ cord-335975-m6lkrehi 796 3 purpose purpose NN cord-335975-m6lkrehi 796 4 of of IN cord-335975-m6lkrehi 796 5 this this DT cord-335975-m6lkrehi 796 6 study study NN cord-335975-m6lkrehi 796 7 was be VBD cord-335975-m6lkrehi 796 8 to to TO cord-335975-m6lkrehi 796 9 assess assess VB cord-335975-m6lkrehi 796 10 the the DT cord-335975-m6lkrehi 796 11 relevance relevance NN cord-335975-m6lkrehi 796 12 of of IN cord-335975-m6lkrehi 796 13 Curvex Curvex NNP cord-335975-m6lkrehi 796 14 as as IN cord-335975-m6lkrehi 796 15 a a DT cord-335975-m6lkrehi 796 16 noninvasive noninvasive JJ cord-335975-m6lkrehi 796 17 diagnostic diagnostic JJ cord-335975-m6lkrehi 796 18 and and CC cord-335975-m6lkrehi 796 19 classification classification NN cord-335975-m6lkrehi 796 20 tool tool NN cord-335975-m6lkrehi 796 21 for for IN cord-335975-m6lkrehi 796 22 asynchronism asynchronism NN cord-335975-m6lkrehi 796 23 management management NN cord-335975-m6lkrehi 796 24 . . . cord-335975-m6lkrehi 797 1 This this DT cord-335975-m6lkrehi 797 2 project project NN cord-335975-m6lkrehi 797 3 is be VBZ cord-335975-m6lkrehi 797 4 based base VBN cord-335975-m6lkrehi 797 5 on on IN cord-335975-m6lkrehi 797 6 a a DT cord-335975-m6lkrehi 797 7 prospective prospective JJ cord-335975-m6lkrehi 797 8 physiological physiological JJ cord-335975-m6lkrehi 797 9 tracing tracing NN cord-335975-m6lkrehi 797 10 data data NN cord-335975-m6lkrehi 797 11 - - HYPH cord-335975-m6lkrehi 797 12 warehousing warehousing NN cord-335975-m6lkrehi 797 13 program program NN cord-335975-m6lkrehi 797 14 ( ( -LRB- cord-335975-m6lkrehi 797 15 Rea Rea NNP cord-335975-m6lkrehi 797 16 STOC STOC NNP cord-335975-m6lkrehi 797 17 , , , cord-335975-m6lkrehi 798 1 clinicaltrials.gov clinicaltrials.gov NNP cord-335975-m6lkrehi 798 2 # # NN cord-335975-m6lkrehi 798 3 NCT02893462 NCT02893462 NNP cord-335975-m6lkrehi 798 4 ) ) -RRB- cord-335975-m6lkrehi 799 1 that that DT cord-335975-m6lkrehi 799 2 aims aim VBZ cord-335975-m6lkrehi 799 3 to to TO cord-335975-m6lkrehi 799 4 record record VB cord-335975-m6lkrehi 799 5 1500 1500 CD cord-335975-m6lkrehi 799 6 consecutive consecutive JJ cord-335975-m6lkrehi 799 7 ICU ICU NNP cord-335975-m6lkrehi 799 8 patients patient NNS cord-335975-m6lkrehi 799 9 , , , cord-335975-m6lkrehi 799 10 over over IN cord-335975-m6lkrehi 799 11 3-years 3-years CD cord-335975-m6lkrehi 799 12 . . . cord-335975-m6lkrehi 800 1 All all DT cord-335975-m6lkrehi 800 2 consecutive consecutive JJ cord-335975-m6lkrehi 800 3 patients patient NNS cord-335975-m6lkrehi 800 4 were be VBD cord-335975-m6lkrehi 800 5 recorded record VBN cord-335975-m6lkrehi 800 6 for for IN cord-335975-m6lkrehi 800 7 a a DT cord-335975-m6lkrehi 800 8 2-hours 2-hours CD cord-335975-m6lkrehi 800 9 period period NN cord-335975-m6lkrehi 800 10 during during IN cord-335975-m6lkrehi 800 11 24-h 24-h JJ cord-335975-m6lkrehi 800 12 following follow VBG cord-335975-m6lkrehi 800 13 ICU ICU NNP cord-335975-m6lkrehi 800 14 admission admission NN cord-335975-m6lkrehi 800 15 . . . cord-335975-m6lkrehi 801 1 All all DT cord-335975-m6lkrehi 801 2 measurements measurement NNS cord-335975-m6lkrehi 801 3 were be VBD cord-335975-m6lkrehi 801 4 recorded record VBN cord-335975-m6lkrehi 801 5 with with IN cord-335975-m6lkrehi 801 6 the the DT cord-335975-m6lkrehi 801 7 patient patient NN cord-335975-m6lkrehi 801 8 laying lay VBG cord-335975-m6lkrehi 801 9 supine supine JJ cord-335975-m6lkrehi 801 10 , , , cord-335975-m6lkrehi 801 11 with with IN cord-335975-m6lkrehi 801 12 a a DT cord-335975-m6lkrehi 801 13 30 30 CD cord-335975-m6lkrehi 801 14 ° ° NN cord-335975-m6lkrehi 801 15 bed bed NN cord-335975-m6lkrehi 801 16 angulation angulation NN cord-335975-m6lkrehi 801 17 . . . cord-335975-m6lkrehi 802 1 Raw raw JJ cord-335975-m6lkrehi 802 2 ventilatory ventilatory JJ cord-335975-m6lkrehi 802 3 pressure pressure NN cord-335975-m6lkrehi 802 4 and and CC cord-335975-m6lkrehi 802 5 flow flow NN cord-335975-m6lkrehi 802 6 curves curve NNS cord-335975-m6lkrehi 802 7 were be VBD cord-335975-m6lkrehi 802 8 transferred transfer VBN cord-335975-m6lkrehi 802 9 to to IN cord-335975-m6lkrehi 802 10 a a DT cord-335975-m6lkrehi 802 11 centralized centralized JJ cord-335975-m6lkrehi 802 12 server server NN cord-335975-m6lkrehi 802 13 using use VBG cord-335975-m6lkrehi 802 14 a a DT cord-335975-m6lkrehi 802 15 dedicated dedicated JJ cord-335975-m6lkrehi 802 16 network network NN cord-335975-m6lkrehi 802 17 . . . cord-335975-m6lkrehi 803 1 The the DT cord-335975-m6lkrehi 803 2 physician physician NN cord-335975-m6lkrehi 803 3 in in IN cord-335975-m6lkrehi 803 4 charge charge NN cord-335975-m6lkrehi 803 5 of of IN cord-335975-m6lkrehi 803 6 the the DT cord-335975-m6lkrehi 803 7 study study NN cord-335975-m6lkrehi 803 8 was be VBD cord-335975-m6lkrehi 803 9 informed inform VBN cord-335975-m6lkrehi 803 10 of of IN cord-335975-m6lkrehi 803 11 the the DT cord-335975-m6lkrehi 803 12 online online JJ cord-335975-m6lkrehi 803 13 analysis analysis NN cord-335975-m6lkrehi 803 14 on on IN cord-335975-m6lkrehi 803 15 a a DT cord-335975-m6lkrehi 803 16 routine routine JJ cord-335975-m6lkrehi 803 17 basis basis NN cord-335975-m6lkrehi 803 18 . . . cord-335975-m6lkrehi 804 1 Physiological physiological JJ cord-335975-m6lkrehi 804 2 recordings recording NNS cord-335975-m6lkrehi 804 3 were be VBD cord-335975-m6lkrehi 804 4 associated associate VBN cord-335975-m6lkrehi 804 5 with with IN cord-335975-m6lkrehi 804 6 metadata metadata NN cord-335975-m6lkrehi 804 7 collection collection NN cord-335975-m6lkrehi 804 8 . . . cord-335975-m6lkrehi 805 1 Asynchronisms asynchronisms NN cord-335975-m6lkrehi 805 2 detection detection NN cord-335975-m6lkrehi 805 3 is be VBZ cord-335975-m6lkrehi 805 4 based base VBN cord-335975-m6lkrehi 805 5 on on IN cord-335975-m6lkrehi 805 6 a a DT cord-335975-m6lkrehi 805 7 non non JJ cord-335975-m6lkrehi 805 8 - - JJ cord-335975-m6lkrehi 805 9 parametric parametric JJ cord-335975-m6lkrehi 805 10 hypothesis hypothesis NN cord-335975-m6lkrehi 805 11 testing testing NN cord-335975-m6lkrehi 805 12 ( ( -LRB- cord-335975-m6lkrehi 805 13 Random Random NNP cord-335975-m6lkrehi 805 14 Distortion Distortion NNP cord-335975-m6lkrehi 805 15 Testing Testing NNP cord-335975-m6lkrehi 805 16 ) ) -RRB- cord-335975-m6lkrehi 805 17 , , , cord-335975-m6lkrehi 805 18 that that WDT cord-335975-m6lkrehi 805 19 requires require VBZ cord-335975-m6lkrehi 805 20 no no DT cord-335975-m6lkrehi 805 21 prior prior JJ cord-335975-m6lkrehi 805 22 information information NN cord-335975-m6lkrehi 805 23 on on IN cord-335975-m6lkrehi 805 24 the the DT cord-335975-m6lkrehi 805 25 signal signal NN cord-335975-m6lkrehi 805 26 distribution distribution NN cord-335975-m6lkrehi 805 27 . . . cord-335975-m6lkrehi 806 1 Beside beside IN cord-335975-m6lkrehi 806 2 Asynchrony Asynchrony NNP cord-335975-m6lkrehi 806 3 Index Index NNP cord-335975-m6lkrehi 806 4 monitoring monitoring NN cord-335975-m6lkrehi 806 5 ( ( -LRB- cord-335975-m6lkrehi 806 6 AI AI NNP cord-335975-m6lkrehi 806 7 ) ) -RRB- cord-335975-m6lkrehi 806 8 , , , cord-335975-m6lkrehi 806 9 five five CD cord-335975-m6lkrehi 806 10 asynchronism asynchronism NN cord-335975-m6lkrehi 806 11 's 's POS cord-335975-m6lkrehi 806 12 types type NNS cord-335975-m6lkrehi 806 13 were be VBD cord-335975-m6lkrehi 806 14 qualified qualified JJ cord-335975-m6lkrehi 806 15 - - HYPH cord-335975-m6lkrehi 806 16 ineffective ineffective JJ cord-335975-m6lkrehi 806 17 efforts effort NNS cord-335975-m6lkrehi 806 18 ( ( -LRB- cord-335975-m6lkrehi 806 19 IE IE NNP cord-335975-m6lkrehi 806 20 ) ) -RRB- cord-335975-m6lkrehi 806 21 , , , cord-335975-m6lkrehi 806 22 short short JJ cord-335975-m6lkrehi 806 23 cycles cycle NNS cord-335975-m6lkrehi 806 24 ( ( -LRB- cord-335975-m6lkrehi 806 25 SC SC NNP cord-335975-m6lkrehi 806 26 ) ) -RRB- cord-335975-m6lkrehi 806 27 , , , cord-335975-m6lkrehi 806 28 multiple multiple JJ cord-335975-m6lkrehi 806 29 cycles cycle NNS cord-335975-m6lkrehi 806 30 ( ( -LRB- cord-335975-m6lkrehi 806 31 MC MC NNP cord-335975-m6lkrehi 806 32 ) ) -RRB- cord-335975-m6lkrehi 806 33 , , , cord-335975-m6lkrehi 806 34 prolonged prolonged JJ cord-335975-m6lkrehi 806 35 inspiration inspiration NN cord-335975-m6lkrehi 806 36 ( ( -LRB- cord-335975-m6lkrehi 806 37 PI pi NN cord-335975-m6lkrehi 806 38 ) ) -RRB- cord-335975-m6lkrehi 806 39 and and CC cord-335975-m6lkrehi 806 40 premature premature JJ cord-335975-m6lkrehi 806 41 cycling cycling NN cord-335975-m6lkrehi 806 42 ( ( -LRB- cord-335975-m6lkrehi 806 43 PC pc NN cord-335975-m6lkrehi 806 44 Introduction introduction NN cord-335975-m6lkrehi 806 45 : : : cord-335975-m6lkrehi 807 1 International international JJ cord-335975-m6lkrehi 807 2 guidelines guideline NNS cord-335975-m6lkrehi 807 3 recommend recommend VBP cord-335975-m6lkrehi 807 4 ultrasound ultrasound NN cord-335975-m6lkrehi 807 5 ( ( -LRB- cord-335975-m6lkrehi 807 6 US US NNP cord-335975-m6lkrehi 807 7 ) ) -RRB- cord-335975-m6lkrehi 807 8 guidance guidance NN cord-335975-m6lkrehi 807 9 for for IN cord-335975-m6lkrehi 807 10 central central JJ cord-335975-m6lkrehi 807 11 venous venous JJ cord-335975-m6lkrehi 807 12 catheter catheter NN cord-335975-m6lkrehi 807 13 ( ( -LRB- cord-335975-m6lkrehi 807 14 CVC CVC NNP cord-335975-m6lkrehi 807 15 ) ) -RRB- cord-335975-m6lkrehi 807 16 insertion insertion NN cord-335975-m6lkrehi 807 17 . . . cord-335975-m6lkrehi 808 1 However however RB cord-335975-m6lkrehi 808 2 , , , cord-335975-m6lkrehi 808 3 evidence evidence NN cord-335975-m6lkrehi 808 4 is be VBZ cord-335975-m6lkrehi 808 5 lacking lack VBG cord-335975-m6lkrehi 808 6 for for IN cord-335975-m6lkrehi 808 7 several several JJ cord-335975-m6lkrehi 808 8 aspects aspect NNS cord-335975-m6lkrehi 808 9 of of IN cord-335975-m6lkrehi 808 10 guidance guidance NN cord-335975-m6lkrehi 808 11 such such JJ cord-335975-m6lkrehi 808 12 as as IN cord-335975-m6lkrehi 808 13 probe probe NN cord-335975-m6lkrehi 808 14 shape shape NN cord-335975-m6lkrehi 808 15 or or CC cord-335975-m6lkrehi 808 16 whether whether IN cord-335975-m6lkrehi 808 17 the the DT cord-335975-m6lkrehi 808 18 needle needle NN cord-335975-m6lkrehi 808 19 has have VBZ cord-335975-m6lkrehi 808 20 to to TO cord-335975-m6lkrehi 808 21 be be VB cord-335975-m6lkrehi 808 22 in in IN cord-335975-m6lkrehi 808 23 plane plane NN cord-335975-m6lkrehi 808 24 ( ( -LRB- cord-335975-m6lkrehi 808 25 IP IP NNP cord-335975-m6lkrehi 808 26 ) ) -RRB- cord-335975-m6lkrehi 808 27 or or CC cord-335975-m6lkrehi 808 28 out out RB cord-335975-m6lkrehi 808 29 - - HYPH cord-335975-m6lkrehi 808 30 of of IN cord-335975-m6lkrehi 808 31 - - HYPH cord-335975-m6lkrehi 808 32 plane plane NN cord-335975-m6lkrehi 808 33 ( ( -LRB- cord-335975-m6lkrehi 808 34 OOP OOP NNP cord-335975-m6lkrehi 808 35 ) ) -RRB- cord-335975-m6lkrehi 808 36 . . . cord-335975-m6lkrehi 809 1 We -PRON- PRP cord-335975-m6lkrehi 809 2 assessed assess VBD cord-335975-m6lkrehi 809 3 these these DT cord-335975-m6lkrehi 809 4 issues issue NNS cord-335975-m6lkrehi 809 5 in in IN cord-335975-m6lkrehi 809 6 a a DT cord-335975-m6lkrehi 809 7 randomized randomized JJ cord-335975-m6lkrehi 809 8 trial trial NN cord-335975-m6lkrehi 809 9 . . . cord-335975-m6lkrehi 810 1 Success success NN cord-335975-m6lkrehi 810 2 at at IN cord-335975-m6lkrehi 810 3 first first JJ cord-335975-m6lkrehi 810 4 pass pass NN cord-335975-m6lkrehi 810 5 , , , cord-335975-m6lkrehi 810 6 number number NN cord-335975-m6lkrehi 810 7 of of IN cord-335975-m6lkrehi 810 8 attempts attempt NNS cord-335975-m6lkrehi 810 9 ( ( -LRB- cord-335975-m6lkrehi 810 10 needle needle NN cord-335975-m6lkrehi 810 11 passes pass VBZ cord-335975-m6lkrehi 810 12 ) ) -RRB- cord-335975-m6lkrehi 810 13 , , , cord-335975-m6lkrehi 810 14 success success NN cord-335975-m6lkrehi 810 15 , , , cord-335975-m6lkrehi 810 16 times time NNS cord-335975-m6lkrehi 810 17 between between IN cord-335975-m6lkrehi 810 18 skin skin NN cord-335975-m6lkrehi 810 19 contact contact NN cord-335975-m6lkrehi 810 20 and and CC cord-335975-m6lkrehi 810 21 needle needle NN cord-335975-m6lkrehi 810 22 skin skin NN cord-335975-m6lkrehi 810 23 penetration penetration NN cord-335975-m6lkrehi 810 24 and and CC cord-335975-m6lkrehi 810 25 between between IN cord-335975-m6lkrehi 810 26 needle needle NN cord-335975-m6lkrehi 810 27 skin skin NN cord-335975-m6lkrehi 810 28 penetration penetration NN cord-335975-m6lkrehi 810 29 and and CC cord-335975-m6lkrehi 810 30 liquid liquid NN cord-335975-m6lkrehi 810 31 back back RP cord-335975-m6lkrehi 810 32 flow flow NN cord-335975-m6lkrehi 810 33 in in IN cord-335975-m6lkrehi 810 34 the the DT cord-335975-m6lkrehi 810 35 syringe syringe NN cord-335975-m6lkrehi 810 36 were be VBD cord-335975-m6lkrehi 810 37 recorded record VBN cord-335975-m6lkrehi 810 38 . . . cord-335975-m6lkrehi 811 1 Qualitative qualitative JJ cord-335975-m6lkrehi 811 2 and and CC cord-335975-m6lkrehi 811 3 quantitative quantitative JJ cord-335975-m6lkrehi 811 4 values value NNS cord-335975-m6lkrehi 811 5 are be VBP cord-335975-m6lkrehi 811 6 expressed express VBN cord-335975-m6lkrehi 811 7 as as IN cord-335975-m6lkrehi 811 8 number number NN cord-335975-m6lkrehi 811 9 ( ( -LRB- cord-335975-m6lkrehi 811 10 percentage percentage NN cord-335975-m6lkrehi 811 11 ) ) -RRB- cord-335975-m6lkrehi 811 12 , , , cord-335975-m6lkrehi 811 13 and and CC cord-335975-m6lkrehi 811 14 median median NN cord-335975-m6lkrehi 811 15 ( ( -LRB- cord-335975-m6lkrehi 811 16 range range NN cord-335975-m6lkrehi 811 17 ) ) -RRB- cord-335975-m6lkrehi 811 18 , , , cord-335975-m6lkrehi 811 19 and and CC cord-335975-m6lkrehi 811 20 were be VBD cord-335975-m6lkrehi 811 21 compared compare VBN cord-335975-m6lkrehi 811 22 using use VBG cord-335975-m6lkrehi 811 23 the the DT cord-335975-m6lkrehi 811 24 Wilcoxon Wilcoxon NNP cord-335975-m6lkrehi 811 25 matched match VBN cord-335975-m6lkrehi 811 26 pairs pair NNS cord-335975-m6lkrehi 811 27 test test NN cord-335975-m6lkrehi 811 28 and and CC cord-335975-m6lkrehi 811 29 the the DT cord-335975-m6lkrehi 811 30 Fisher Fisher NNP cord-335975-m6lkrehi 811 31 exact exact JJ cord-335975-m6lkrehi 811 32 test test NN cord-335975-m6lkrehi 811 33 , , , cord-335975-m6lkrehi 811 34 respectively respectively RB cord-335975-m6lkrehi 811 35 . . . cord-335975-m6lkrehi 812 1 Results result NNS cord-335975-m6lkrehi 812 2 : : : cord-335975-m6lkrehi 813 1 For for IN cord-335975-m6lkrehi 813 2 IJV IJV NNP cord-335975-m6lkrehi 813 3 puncture puncture NN cord-335975-m6lkrehi 813 4 , , , cord-335975-m6lkrehi 813 5 first first JJ cord-335975-m6lkrehi 813 6 attempt attempt NN cord-335975-m6lkrehi 813 7 success success NN cord-335975-m6lkrehi 813 8 rate rate NN cord-335975-m6lkrehi 813 9 was be VBD cord-335975-m6lkrehi 813 10 more more JJR cord-335975-m6lkrehi 813 11 than than IN cord-335975-m6lkrehi 813 12 80 80 CD cord-335975-m6lkrehi 813 13 % % NN cord-335975-m6lkrehi 813 14 and and CC cord-335975-m6lkrehi 813 15 was be VBD cord-335975-m6lkrehi 813 16 neither neither RB cord-335975-m6lkrehi 813 17 influenced influence VBN cord-335975-m6lkrehi 813 18 by by IN cord-335975-m6lkrehi 813 19 probe probe NN cord-335975-m6lkrehi 813 20 shape shape NN cord-335975-m6lkrehi 813 21 nor nor CC cord-335975-m6lkrehi 813 22 approach approach NN cord-335975-m6lkrehi 813 23 ( ( -LRB- cord-335975-m6lkrehi 813 24 Table table NN cord-335975-m6lkrehi 813 25 1 1 CD cord-335975-m6lkrehi 813 26 ) ) -RRB- cord-335975-m6lkrehi 813 27 . . . cord-335975-m6lkrehi 814 1 Conversely conversely RB cord-335975-m6lkrehi 814 2 for for IN cord-335975-m6lkrehi 814 3 RAV RAV NNP cord-335975-m6lkrehi 814 4 puncture puncture NN cord-335975-m6lkrehi 814 5 , , , cord-335975-m6lkrehi 814 6 using use VBG cord-335975-m6lkrehi 814 7 LP LP NNP cord-335975-m6lkrehi 814 8 with with IN cord-335975-m6lkrehi 814 9 IP ip NN cord-335975-m6lkrehi 814 10 approach approach NN cord-335975-m6lkrehi 814 11 was be VBD cord-335975-m6lkrehi 814 12 more more RBR cord-335975-m6lkrehi 814 13 frequently frequently RB cord-335975-m6lkrehi 814 14 successful successful JJ cord-335975-m6lkrehi 814 15 at at IN cord-335975-m6lkrehi 814 16 first first JJ cord-335975-m6lkrehi 814 17 attempt attempt NN cord-335975-m6lkrehi 814 18 ( ( -LRB- cord-335975-m6lkrehi 814 19 45 45 CD cord-335975-m6lkrehi 814 20 vs vs IN cord-335975-m6lkrehi 814 21 34 34 CD cord-335975-m6lkrehi 814 22 % % NN cord-335975-m6lkrehi 814 23 , , , cord-335975-m6lkrehi 814 24 p p NN cord-335975-m6lkrehi 814 25 = = SYM cord-335975-m6lkrehi 814 26 0.2 0.2 CD cord-335975-m6lkrehi 814 27 ) ) -RRB- cord-335975-m6lkrehi 814 28 . . . cord-335975-m6lkrehi 815 1 Time time NN cord-335975-m6lkrehi 815 2 elapsed elapse VBN cord-335975-m6lkrehi 815 3 between between IN cord-335975-m6lkrehi 815 4 needle needle NN cord-335975-m6lkrehi 815 5 skin skin NN cord-335975-m6lkrehi 815 6 penetration penetration NN cord-335975-m6lkrehi 815 7 and and CC cord-335975-m6lkrehi 815 8 liquid liquid NN cord-335975-m6lkrehi 815 9 back back RP cord-335975-m6lkrehi 815 10 flow flow NN cord-335975-m6lkrehi 815 11 was be VBD cord-335975-m6lkrehi 815 12 shorter short JJR cord-335975-m6lkrehi 815 13 for for IN cord-335975-m6lkrehi 816 1 RAV RAV NNP cord-335975-m6lkrehi 816 2 puncture puncture NN cord-335975-m6lkrehi 816 3 using use VBG cord-335975-m6lkrehi 816 4 IP ip NN cord-335975-m6lkrehi 816 5 approach approach NN cord-335975-m6lkrehi 816 6 ( ( -LRB- cord-335975-m6lkrehi 816 7 16 16 CD cord-335975-m6lkrehi 816 8 s s NN cord-335975-m6lkrehi 816 9 vs vs IN cord-335975-m6lkrehi 816 10 34 34 CD cord-335975-m6lkrehi 816 11 s s NNPS cord-335975-m6lkrehi 816 12 , , , cord-335975-m6lkrehi 816 13 p p NN cord-335975-m6lkrehi 816 14 = = SYM cord-335975-m6lkrehi 816 15 0.03 0.03 CD cord-335975-m6lkrehi 816 16 ) ) -RRB- cord-335975-m6lkrehi 816 17 . . . cord-335975-m6lkrehi 817 1 Time time NN cord-335975-m6lkrehi 817 2 elapsed elapse VBN cord-335975-m6lkrehi 817 3 between between IN cord-335975-m6lkrehi 817 4 probe probe NN cord-335975-m6lkrehi 817 5 appliance appliance NN cord-335975-m6lkrehi 817 6 on on IN cord-335975-m6lkrehi 817 7 skin skin NN cord-335975-m6lkrehi 817 8 and and CC cord-335975-m6lkrehi 817 9 liquid liquid NN cord-335975-m6lkrehi 817 10 back back RP cord-335975-m6lkrehi 817 11 flow flow NN cord-335975-m6lkrehi 817 12 was be VBD cord-335975-m6lkrehi 817 13 significantly significantly RB cord-335975-m6lkrehi 817 14 shorter short JJR cord-335975-m6lkrehi 817 15 with with IN cord-335975-m6lkrehi 817 16 the the DT cord-335975-m6lkrehi 817 17 linear linear JJ cord-335975-m6lkrehi 817 18 probe probe NN cord-335975-m6lkrehi 817 19 for for IN cord-335975-m6lkrehi 817 20 IJV IJV NNP cord-335975-m6lkrehi 818 1 whatever whatever WDT cord-335975-m6lkrehi 818 2 the the DT cord-335975-m6lkrehi 818 3 approach approach NN cord-335975-m6lkrehi 818 4 and and CC cord-335975-m6lkrehi 818 5 for for IN cord-335975-m6lkrehi 818 6 RAV RAV NNP cord-335975-m6lkrehi 818 7 using use VBG cord-335975-m6lkrehi 818 8 IP ip NN cord-335975-m6lkrehi 818 9 approach approach NN cord-335975-m6lkrehi 818 10 . . . cord-335975-m6lkrehi 819 1 RAV RAV NNP cord-335975-m6lkrehi 819 2 puncture puncture NN cord-335975-m6lkrehi 819 3 was be VBD cord-335975-m6lkrehi 819 4 more more RBR cord-335975-m6lkrehi 819 5 frequently frequently RB cord-335975-m6lkrehi 819 6 impossible impossible JJ cord-335975-m6lkrehi 819 7 with with IN cord-335975-m6lkrehi 819 8 MCP MCP NNP cord-335975-m6lkrehi 819 9 ( ( -LRB- cord-335975-m6lkrehi 819 10 10 10 CD cord-335975-m6lkrehi 819 11 vs vs IN cord-335975-m6lkrehi 819 12 3 3 CD cord-335975-m6lkrehi 819 13 % % NN cord-335975-m6lkrehi 819 14 , , , cord-335975-m6lkrehi 819 15 p p NN cord-335975-m6lkrehi 819 16 = = SYM cord-335975-m6lkrehi 819 17 0.08 0.08 CD cord-335975-m6lkrehi 819 18 ) ) -RRB- cord-335975-m6lkrehi 819 19 . . . cord-335975-m6lkrehi 820 1 Arterial arterial JJ cord-335975-m6lkrehi 820 2 puncture puncture NN cord-335975-m6lkrehi 820 3 occurred occur VBD cord-335975-m6lkrehi 820 4 more more RBR cord-335975-m6lkrehi 820 5 frequently frequently RB cord-335975-m6lkrehi 820 6 with with IN cord-335975-m6lkrehi 820 7 MCP MCP NNP cord-335975-m6lkrehi 820 8 ( ( -LRB- cord-335975-m6lkrehi 820 9 7 7 CD cord-335975-m6lkrehi 820 10 vs vs IN cord-335975-m6lkrehi 820 11 3 3 CD cord-335975-m6lkrehi 820 12 % % NN cord-335975-m6lkrehi 820 13 , , , cord-335975-m6lkrehi 820 14 p p NN cord-335975-m6lkrehi 820 15 = = SYM cord-335975-m6lkrehi 820 16 0.08 0.08 CD cord-335975-m6lkrehi 820 17 ) ) -RRB- cord-335975-m6lkrehi 820 18 . . . cord-335975-m6lkrehi 821 1 LP LP NNP cord-335975-m6lkrehi 821 2 use use NN cord-335975-m6lkrehi 821 3 and and CC cord-335975-m6lkrehi 821 4 IP ip NN cord-335975-m6lkrehi 821 5 approach approach NN cord-335975-m6lkrehi 821 6 were be VBD cord-335975-m6lkrehi 821 7 associated associate VBN cord-335975-m6lkrehi 821 8 with with IN cord-335975-m6lkrehi 821 9 more more RBR cord-335975-m6lkrehi 821 10 free free JJ cord-335975-m6lkrehi 821 11 event event NN cord-335975-m6lkrehi 821 12 puncture puncture NN cord-335975-m6lkrehi 821 13 ( ( -LRB- cord-335975-m6lkrehi 821 14 ± ± CD cord-335975-m6lkrehi 821 15 20 20 CD cord-335975-m6lkrehi 821 16 ) ) -RRB- cord-335975-m6lkrehi 821 17 . . . cord-335975-m6lkrehi 822 1 Minimal minimal JJ cord-335975-m6lkrehi 822 2 ANI ANI NNP cord-335975-m6lkrehi 822 3 , , , cord-335975-m6lkrehi 822 4 reflecting reflect VBG cord-335975-m6lkrehi 822 5 intense intense JJ cord-335975-m6lkrehi 822 6 stress stress NN cord-335975-m6lkrehi 822 7 was be VBD cord-335975-m6lkrehi 822 8 33.7 33.7 CD cord-335975-m6lkrehi 822 9 ( ( -LRB- cord-335975-m6lkrehi 822 10 ± ± NNP cord-335975-m6lkrehi 822 11 9.9 9.9 CD cord-335975-m6lkrehi 822 12 ) ) -RRB- cord-335975-m6lkrehi 822 13 . . . cord-335975-m6lkrehi 823 1 Objective objective JJ cord-335975-m6lkrehi 823 2 and and CC cord-335975-m6lkrehi 823 3 subjective subjective JJ cord-335975-m6lkrehi 823 4 stress stress NN cord-335975-m6lkrehi 823 5 of of IN cord-335975-m6lkrehi 823 6 each each DT cord-335975-m6lkrehi 823 7 team team NN cord-335975-m6lkrehi 823 8 leader leader NN cord-335975-m6lkrehi 823 9 is be VBZ cord-335975-m6lkrehi 823 10 shown show VBN cord-335975-m6lkrehi 823 11 in in IN cord-335975-m6lkrehi 823 12 Fig Fig NNP cord-335975-m6lkrehi 823 13 . . . cord-335975-m6lkrehi 824 1 1 1 LS cord-335975-m6lkrehi 824 2 . . . cord-335975-m6lkrehi 825 1 There there EX cord-335975-m6lkrehi 825 2 was be VBD cord-335975-m6lkrehi 825 3 a a DT cord-335975-m6lkrehi 825 4 significant significant JJ cord-335975-m6lkrehi 825 5 negative negative JJ cord-335975-m6lkrehi 825 6 linear linear JJ cord-335975-m6lkrehi 825 7 correlation correlation NN cord-335975-m6lkrehi 825 8 between between IN cord-335975-m6lkrehi 825 9 minimal minimal JJ cord-335975-m6lkrehi 825 10 ANI ani NN cord-335975-m6lkrehi 825 11 and and CC cord-335975-m6lkrehi 825 12 maximal maximal JJ cord-335975-m6lkrehi 825 13 HR hr NN cord-335975-m6lkrehi 825 14 ( ( -LRB- cord-335975-m6lkrehi 825 15 Rho rho NN cord-335975-m6lkrehi 825 16 = = SYM cord-335975-m6lkrehi 825 17 − − NNP cord-335975-m6lkrehi 825 18 0.52 0.52 CD cord-335975-m6lkrehi 825 19 , , , cord-335975-m6lkrehi 825 20 p p NN cord-335975-m6lkrehi 825 21 = = SYM cord-335975-m6lkrehi 825 22 0.001 0.001 CD cord-335975-m6lkrehi 825 23 ) ) -RRB- cord-335975-m6lkrehi 825 24 . . . cord-335975-m6lkrehi 826 1 There there EX cord-335975-m6lkrehi 826 2 was be VBD cord-335975-m6lkrehi 826 3 no no DT cord-335975-m6lkrehi 826 4 significant significant JJ cord-335975-m6lkrehi 826 5 correlation correlation NN cord-335975-m6lkrehi 826 6 between between IN cord-335975-m6lkrehi 826 7 self self NN cord-335975-m6lkrehi 826 8 - - HYPH cord-335975-m6lkrehi 826 9 reported report VBN cord-335975-m6lkrehi 826 10 stress stress NN cord-335975-m6lkrehi 826 11 VAS VAS NNP cord-335975-m6lkrehi 826 12 ( ( -LRB- cord-335975-m6lkrehi 826 13 neither neither DT cord-335975-m6lkrehi 826 14 pre pre JJ cord-335975-m6lkrehi 826 15 HFS HFS NNP cord-335975-m6lkrehi 826 16 or or CC cord-335975-m6lkrehi 826 17 maximal maximal JJ cord-335975-m6lkrehi 826 18 stress stress NN cord-335975-m6lkrehi 826 19 ) ) -RRB- cord-335975-m6lkrehi 826 20 and and CC cord-335975-m6lkrehi 826 21 minimal minimal JJ cord-335975-m6lkrehi 826 22 ANI ani NN cord-335975-m6lkrehi 826 23 . . . cord-335975-m6lkrehi 827 1 Conclusion conclusion NN cord-335975-m6lkrehi 827 2 : : : cord-335975-m6lkrehi 828 1 HRV HRV NNP cord-335975-m6lkrehi 828 2 monitoring monitoring NN cord-335975-m6lkrehi 828 3 is be VBZ cord-335975-m6lkrehi 828 4 a a DT cord-335975-m6lkrehi 828 5 feasible feasible JJ cord-335975-m6lkrehi 828 6 method method NN cord-335975-m6lkrehi 828 7 to to TO cord-335975-m6lkrehi 828 8 evaluate evaluate VB cord-335975-m6lkrehi 828 9 continuous continuous JJ cord-335975-m6lkrehi 828 10 physiological physiological JJ cord-335975-m6lkrehi 828 11 stress stress NN cord-335975-m6lkrehi 828 12 for for IN cord-335975-m6lkrehi 828 13 team team NN cord-335975-m6lkrehi 828 14 leaders leader NNS cord-335975-m6lkrehi 828 15 in in IN cord-335975-m6lkrehi 828 16 highly highly RB cord-335975-m6lkrehi 828 17 stressful stressful JJ cord-335975-m6lkrehi 828 18 simulationteaching simulationteaching NN cord-335975-m6lkrehi 828 19 . . . cord-335975-m6lkrehi 829 1 Upgrading upgrade VBG cord-335975-m6lkrehi 829 2 signal signal NN cord-335975-m6lkrehi 829 3 connection connection NN cord-335975-m6lkrehi 829 4 by by IN cord-335975-m6lkrehi 829 5 Bluetooth Bluetooth NNP cord-335975-m6lkrehi 829 6 4.0 4.0 CD cord-335975-m6lkrehi 829 7 or or CC cord-335975-m6lkrehi 829 8 Wi Wi NNP cord-335975-m6lkrehi 829 9 - - HYPH cord-335975-m6lkrehi 829 10 fi fi NNP cord-335975-m6lkrehi 829 11 could could MD cord-335975-m6lkrehi 829 12 improve improve VB cord-335975-m6lkrehi 829 13 the the DT cord-335975-m6lkrehi 829 14 method method NN cord-335975-m6lkrehi 829 15 . . . cord-335975-m6lkrehi 830 1 Focusing focus VBG cord-335975-m6lkrehi 830 2 on on IN cord-335975-m6lkrehi 830 3 specific specific JJ cord-335975-m6lkrehi 830 4 stressful stressful JJ cord-335975-m6lkrehi 830 5 time time NN cord-335975-m6lkrehi 830 6 points point NNS cord-335975-m6lkrehi 830 7 might may MD cord-335975-m6lkrehi 830 8 improve improve VB cord-335975-m6lkrehi 830 9 stress stress NN cord-335975-m6lkrehi 830 10 assessment assessment NN cord-335975-m6lkrehi 830 11 and and CC cord-335975-m6lkrehi 830 12 its -PRON- PRP$ cord-335975-m6lkrehi 830 13 correlation correlation NN cord-335975-m6lkrehi 830 14 with with IN cord-335975-m6lkrehi 830 15 performance performance NN cord-335975-m6lkrehi 830 16 . . . cord-335975-m6lkrehi 831 1 Introduction introduction NN cord-335975-m6lkrehi 831 2 : : : cord-335975-m6lkrehi 832 1 Simulation simulation NN cord-335975-m6lkrehi 832 2 training training NN cord-335975-m6lkrehi 832 3 has have VBZ cord-335975-m6lkrehi 832 4 become become VBN cord-335975-m6lkrehi 832 5 available available JJ cord-335975-m6lkrehi 832 6 in in IN cord-335975-m6lkrehi 832 7 Health Health NNP cord-335975-m6lkrehi 832 8 sciences science NNS cord-335975-m6lkrehi 832 9 faculties faculty NNS cord-335975-m6lkrehi 832 10 and and CC cord-335975-m6lkrehi 832 11 proposed propose VBN cord-335975-m6lkrehi 832 12 in in IN cord-335975-m6lkrehi 832 13 many many JJ cord-335975-m6lkrehi 832 14 specialties specialty NNS cord-335975-m6lkrehi 832 15 . . . cord-335975-m6lkrehi 833 1 Intensive Intensive NNP cord-335975-m6lkrehi 833 2 Care Care NNP cord-335975-m6lkrehi 833 3 is be VBZ cord-335975-m6lkrehi 833 4 one one CD cord-335975-m6lkrehi 833 5 of of IN cord-335975-m6lkrehi 833 6 the the DT cord-335975-m6lkrehi 833 7 fields field NNS cord-335975-m6lkrehi 833 8 of of IN cord-335975-m6lkrehi 833 9 development development NN cord-335975-m6lkrehi 833 10 of of IN cord-335975-m6lkrehi 833 11 simulation simulation NN cord-335975-m6lkrehi 833 12 based base VBN cord-335975-m6lkrehi 833 13 training training NN cord-335975-m6lkrehi 833 14 . . . cord-335975-m6lkrehi 834 1 The the DT cord-335975-m6lkrehi 834 2 aim aim NN cord-335975-m6lkrehi 834 3 of of IN cord-335975-m6lkrehi 834 4 the the DT cord-335975-m6lkrehi 834 5 present present JJ cord-335975-m6lkrehi 834 6 study study NN cord-335975-m6lkrehi 834 7 was be VBD cord-335975-m6lkrehi 834 8 to to TO cord-335975-m6lkrehi 834 9 report report VB cord-335975-m6lkrehi 834 10 the the DT cord-335975-m6lkrehi 834 11 experience experience NN cord-335975-m6lkrehi 834 12 of of IN cord-335975-m6lkrehi 834 13 the the DT cord-335975-m6lkrehi 834 14 Faculty Faculty NNP cord-335975-m6lkrehi 834 15 of of IN cord-335975-m6lkrehi 834 16 Medicine Medicine NNP cord-335975-m6lkrehi 834 17 of of IN cord-335975-m6lkrehi 834 18 Monastir Monastir NNP cord-335975-m6lkrehi 834 19 Simulation Simulation NNP cord-335975-m6lkrehi 834 20 Center Center NNP cord-335975-m6lkrehi 834 21 in in IN cord-335975-m6lkrehi 834 22 training train VBG cord-335975-m6lkrehi 834 23 medical medical JJ cord-335975-m6lkrehi 834 24 students student NNS cord-335975-m6lkrehi 834 25 and and CC cord-335975-m6lkrehi 834 26 residents resident NNS cord-335975-m6lkrehi 834 27 in in IN cord-335975-m6lkrehi 834 28 Intensive Intensive NNP cord-335975-m6lkrehi 834 29 Care Care NNP cord-335975-m6lkrehi 834 30 and and CC cord-335975-m6lkrehi 834 31 to to TO cord-335975-m6lkrehi 834 32 compare compare VB cord-335975-m6lkrehi 834 33 their -PRON- PRP$ cord-335975-m6lkrehi 834 34 respective respective JJ cord-335975-m6lkrehi 834 35 perceptions perception NNS cord-335975-m6lkrehi 834 36 . . . cord-335975-m6lkrehi 835 1 This this DT cord-335975-m6lkrehi 835 2 was be VBD cord-335975-m6lkrehi 835 3 a a DT cord-335975-m6lkrehi 835 4 descriptive descriptive JJ cord-335975-m6lkrehi 835 5 study study NN cord-335975-m6lkrehi 835 6 including include VBG cord-335975-m6lkrehi 835 7 students student NNS cord-335975-m6lkrehi 835 8 ( ( -LRB- cord-335975-m6lkrehi 835 9 5th 5th JJ cord-335975-m6lkrehi 835 10 year year NN cord-335975-m6lkrehi 835 11 of of IN cord-335975-m6lkrehi 835 12 the the DT cord-335975-m6lkrehi 835 13 medical medical JJ cord-335975-m6lkrehi 835 14 curriculum curriculum NN cord-335975-m6lkrehi 835 15 ) ) -RRB- cord-335975-m6lkrehi 835 16 and and CC cord-335975-m6lkrehi 835 17 residents resident NNS cord-335975-m6lkrehi 835 18 who who WP cord-335975-m6lkrehi 835 19 received receive VBD cord-335975-m6lkrehi 835 20 training training NN cord-335975-m6lkrehi 835 21 during during IN cord-335975-m6lkrehi 835 22 the the DT cord-335975-m6lkrehi 835 23 last last JJ cord-335975-m6lkrehi 835 24 academic academic JJ cord-335975-m6lkrehi 835 25 year year NN cord-335975-m6lkrehi 835 26 ( ( -LRB- cord-335975-m6lkrehi 835 27 2016 2016 CD cord-335975-m6lkrehi 835 28 ) ) -RRB- cord-335975-m6lkrehi 835 29 ( ( -LRB- cord-335975-m6lkrehi 835 30 2017 2017 CD cord-335975-m6lkrehi 835 31 ) ) -RRB- cord-335975-m6lkrehi 835 32 , , , cord-335975-m6lkrehi 835 33 in in IN cord-335975-m6lkrehi 835 34 the the DT cord-335975-m6lkrehi 835 35 simulation simulation NN cord-335975-m6lkrehi 835 36 center center NN cord-335975-m6lkrehi 835 37 during during IN cord-335975-m6lkrehi 835 38 their -PRON- PRP$ cord-335975-m6lkrehi 835 39 ICU ICU NNP cord-335975-m6lkrehi 835 40 traineeship traineeship NN cord-335975-m6lkrehi 835 41 . . . cord-335975-m6lkrehi 836 1 Simulation simulation NN cord-335975-m6lkrehi 836 2 training training NN cord-335975-m6lkrehi 836 3 was be VBD cord-335975-m6lkrehi 836 4 based base VBN cord-335975-m6lkrehi 836 5 on on IN cord-335975-m6lkrehi 836 6 high high JJ cord-335975-m6lkrehi 836 7 - - HYPH cord-335975-m6lkrehi 836 8 fidelity fidelity NN cord-335975-m6lkrehi 836 9 mannequins mannequin NNS cord-335975-m6lkrehi 836 10 for for IN cord-335975-m6lkrehi 836 11 students student NNS cord-335975-m6lkrehi 836 12 and and CC cord-335975-m6lkrehi 836 13 seminars seminar NNS cord-335975-m6lkrehi 836 14 with with IN cord-335975-m6lkrehi 836 15 high high JJ cord-335975-m6lkrehi 836 16 fidelity fidelity NN cord-335975-m6lkrehi 836 17 and and CC cord-335975-m6lkrehi 836 18 procedural procedural JJ cord-335975-m6lkrehi 836 19 simulation simulation NN cord-335975-m6lkrehi 836 20 training training NN cord-335975-m6lkrehi 836 21 for for IN cord-335975-m6lkrehi 836 22 residents resident NNS cord-335975-m6lkrehi 836 23 . . . cord-335975-m6lkrehi 837 1 Three three CD cord-335975-m6lkrehi 837 2 sessions session NNS cord-335975-m6lkrehi 837 3 per per IN cord-335975-m6lkrehi 837 4 group group NN cord-335975-m6lkrehi 837 5 were be VBD cord-335975-m6lkrehi 837 6 organized organize VBN cord-335975-m6lkrehi 837 7 for for IN cord-335975-m6lkrehi 837 8 students student NNS cord-335975-m6lkrehi 837 9 and and CC cord-335975-m6lkrehi 837 10 a a DT cord-335975-m6lkrehi 837 11 total total NN cord-335975-m6lkrehi 837 12 of of IN cord-335975-m6lkrehi 837 13 five five CD cord-335975-m6lkrehi 837 14 sessions session NNS cord-335975-m6lkrehi 837 15 for for IN cord-335975-m6lkrehi 837 16 residents resident NNS cord-335975-m6lkrehi 837 17 . . . cord-335975-m6lkrehi 838 1 We -PRON- PRP cord-335975-m6lkrehi 838 2 collected collect VBD cord-335975-m6lkrehi 838 3 participant participant NN cord-335975-m6lkrehi 838 4 characteristics characteristic NNS cord-335975-m6lkrehi 838 5 and and CC cord-335975-m6lkrehi 838 6 used use VBD cord-335975-m6lkrehi 838 7 Likert Likert NNP cord-335975-m6lkrehi 838 8 scale scale NN cord-335975-m6lkrehi 838 9 ( ( -LRB- cord-335975-m6lkrehi 838 10 from from IN cord-335975-m6lkrehi 838 11 1 1 CD cord-335975-m6lkrehi 838 12 to to IN cord-335975-m6lkrehi 838 13 5 5 CD cord-335975-m6lkrehi 838 14 ) ) -RRB- cord-335975-m6lkrehi 838 15 to to TO cord-335975-m6lkrehi 838 16 assess assess VB cord-335975-m6lkrehi 838 17 participant participant NN cord-335975-m6lkrehi 838 18 satisfaction satisfaction NN cord-335975-m6lkrehi 838 19 , , , cord-335975-m6lkrehi 838 20 simulation simulation NN cord-335975-m6lkrehi 838 21 fidelity fidelity NN cord-335975-m6lkrehi 838 22 , , , cord-335975-m6lkrehi 838 23 impact impact NN cord-335975-m6lkrehi 838 24 on on IN cord-335975-m6lkrehi 838 25 clinical clinical JJ cord-335975-m6lkrehi 838 26 practice practice NN cord-335975-m6lkrehi 838 27 , , , cord-335975-m6lkrehi 838 28 stress stress NN cord-335975-m6lkrehi 838 29 level level NN cord-335975-m6lkrehi 838 30 and and CC cord-335975-m6lkrehi 838 31 instructor instructor NN cord-335975-m6lkrehi 838 32 behaviors behavior NNS cord-335975-m6lkrehi 838 33 . . . cord-335975-m6lkrehi 839 1 Chi Chi NNP cord-335975-m6lkrehi 839 2 2 2 CD cord-335975-m6lkrehi 839 3 test test NN cord-335975-m6lkrehi 839 4 was be VBD cord-335975-m6lkrehi 839 5 used use VBN cord-335975-m6lkrehi 839 6 to to TO cord-335975-m6lkrehi 839 7 compare compare VB cord-335975-m6lkrehi 839 8 students student NNS cord-335975-m6lkrehi 839 9 ' ' POS cord-335975-m6lkrehi 839 10 and and CC cord-335975-m6lkrehi 839 11 residents resident NNS cord-335975-m6lkrehi 839 12 ' ' POS cord-335975-m6lkrehi 839 13 perception perception NN cord-335975-m6lkrehi 839 14 of of IN cord-335975-m6lkrehi 839 15 the the DT cord-335975-m6lkrehi 839 16 simulation simulation NN cord-335975-m6lkrehi 839 17 based base VBN cord-335975-m6lkrehi 839 18 - - HYPH cord-335975-m6lkrehi 839 19 training training NN cord-335975-m6lkrehi 839 20 . . . cord-335975-m6lkrehi 840 1 Results result NNS cord-335975-m6lkrehi 840 2 : : : cord-335975-m6lkrehi 841 1 During during IN cord-335975-m6lkrehi 841 2 the the DT cord-335975-m6lkrehi 841 3 study study NN cord-335975-m6lkrehi 841 4 period period NN cord-335975-m6lkrehi 841 5 91 91 CD cord-335975-m6lkrehi 841 6 students student NNS cord-335975-m6lkrehi 841 7 ( ( -LRB- cord-335975-m6lkrehi 841 8 of of IN cord-335975-m6lkrehi 841 9 the the DT cord-335975-m6lkrehi 841 10 269 269 CD cord-335975-m6lkrehi 841 11 students student NNS cord-335975-m6lkrehi 841 12 ' ' POS cord-335975-m6lkrehi 841 13 whole whole JJ cord-335975-m6lkrehi 841 14 promotion promotion NN cord-335975-m6lkrehi 841 15 ) ) -RRB- cord-335975-m6lkrehi 841 16 and and CC cord-335975-m6lkrehi 841 17 88 88 CD cord-335975-m6lkrehi 841 18 residents resident NNS cord-335975-m6lkrehi 841 19 actively actively RB cord-335975-m6lkrehi 841 20 participated participate VBD cord-335975-m6lkrehi 841 21 at at IN cord-335975-m6lkrehi 841 22 least least JJS cord-335975-m6lkrehi 841 23 in in IN cord-335975-m6lkrehi 841 24 one one CD cord-335975-m6lkrehi 841 25 of of IN cord-335975-m6lkrehi 841 26 the the DT cord-335975-m6lkrehi 841 27 simulation simulation NN cord-335975-m6lkrehi 841 28 - - HYPH cord-335975-m6lkrehi 841 29 based base VBN cord-335975-m6lkrehi 841 30 training training NN cord-335975-m6lkrehi 841 31 sessions session NNS cord-335975-m6lkrehi 841 32 . . . cord-335975-m6lkrehi 842 1 Median median JJ cord-335975-m6lkrehi 842 2 students student NNS cord-335975-m6lkrehi 842 3 ' ' POS cord-335975-m6lkrehi 842 4 and and CC cord-335975-m6lkrehi 842 5 residents resident NNS cord-335975-m6lkrehi 842 6 ' ' POS cord-335975-m6lkrehi 842 7 ages age NNS cord-335975-m6lkrehi 842 8 were be VBD cord-335975-m6lkrehi 842 9 respectively respectively RB cord-335975-m6lkrehi 842 10 24 24 CD cord-335975-m6lkrehi 842 11 years year NNS cord-335975-m6lkrehi 842 12 ( ( -LRB- cord-335975-m6lkrehi 842 13 24 24 CD cord-335975-m6lkrehi 842 14 - - SYM cord-335975-m6lkrehi 842 15 24 24 CD cord-335975-m6lkrehi 842 16 ) ) -RRB- cord-335975-m6lkrehi 842 17 and and CC cord-335975-m6lkrehi 842 18 29 29 CD cord-335975-m6lkrehi 842 19 years year NNS cord-335975-m6lkrehi 843 1 ( ( -LRB- cord-335975-m6lkrehi 843 2 Introduction introduction NN cord-335975-m6lkrehi 843 3 : : : cord-335975-m6lkrehi 843 4 Hospitals hospital NNS cord-335975-m6lkrehi 843 5 are be VBP cord-335975-m6lkrehi 843 6 encouraged encourage VBN cord-335975-m6lkrehi 843 7 to to TO cord-335975-m6lkrehi 843 8 edit edit VB cord-335975-m6lkrehi 843 9 local local JJ cord-335975-m6lkrehi 843 10 antibiotic antibiotic JJ cord-335975-m6lkrehi 843 11 therapy therapy NN cord-335975-m6lkrehi 843 12 guidelines guideline NNS cord-335975-m6lkrehi 843 13 . . . cord-335975-m6lkrehi 844 1 ANTIBIOGARDE ANTIBIOGARDE NNP cord-335975-m6lkrehi 844 2 ® ® VBP cord-335975-m6lkrehi 844 3 is be VBZ cord-335975-m6lkrehi 844 4 an an DT cord-335975-m6lkrehi 844 5 electronic electronic JJ cord-335975-m6lkrehi 844 6 antibiotic antibiotic JJ cord-335975-m6lkrehi 844 7 prescription prescription NN cord-335975-m6lkrehi 844 8 referential referential NN cord-335975-m6lkrehi 844 9 developed develop VBN cord-335975-m6lkrehi 844 10 by by IN cord-335975-m6lkrehi 844 11 a a DT cord-335975-m6lkrehi 844 12 multidisciplinary multidisciplinary JJ cord-335975-m6lkrehi 844 13 team team NN cord-335975-m6lkrehi 844 14 of of IN cord-335975-m6lkrehi 844 15 French french JJ cord-335975-m6lkrehi 844 16 physicians physician NNS cord-335975-m6lkrehi 844 17 , , , cord-335975-m6lkrehi 844 18 regularly regularly RB cord-335975-m6lkrehi 844 19 updated update VBD cord-335975-m6lkrehi 844 20 , , , cord-335975-m6lkrehi 844 21 and and CC cord-335975-m6lkrehi 844 22 locally locally RB cord-335975-m6lkrehi 844 23 customizable customizable JJ cord-335975-m6lkrehi 844 24 , , , cord-335975-m6lkrehi 844 25 which which WDT cord-335975-m6lkrehi 844 26 has have VBZ cord-335975-m6lkrehi 844 27 been be VBN cord-335975-m6lkrehi 844 28 purchased purchase VBN cord-335975-m6lkrehi 844 29 by by IN cord-335975-m6lkrehi 844 30 more more JJR cord-335975-m6lkrehi 844 31 than than IN cord-335975-m6lkrehi 844 32 170 170 CD cord-335975-m6lkrehi 844 33 French french JJ cord-335975-m6lkrehi 844 34 hospitals hospital NNS cord-335975-m6lkrehi 844 35 . . . cord-335975-m6lkrehi 845 1 We -PRON- PRP cord-335975-m6lkrehi 845 2 compared compare VBD cord-335975-m6lkrehi 845 3 adequacy adequacy NN cord-335975-m6lkrehi 845 4 Fig Fig NNP cord-335975-m6lkrehi 845 5 . . . cord-335975-m6lkrehi 846 1 1 1 CD cord-335975-m6lkrehi 846 2 Team Team NNP cord-335975-m6lkrehi 846 3 leader leader NN cord-335975-m6lkrehi 846 4 's 's POS cord-335975-m6lkrehi 846 5 objective objective JJ cord-335975-m6lkrehi 846 6 ( ( -LRB- cord-335975-m6lkrehi 846 7 heart heart NN cord-335975-m6lkrehi 846 8 rate rate NN cord-335975-m6lkrehi 846 9 and and CC cord-335975-m6lkrehi 846 10 ANI ANI NNP cord-335975-m6lkrehi 846 11 ) ) -RRB- cord-335975-m6lkrehi 846 12 and and CC cord-335975-m6lkrehi 846 13 subjective subjective JJ cord-335975-m6lkrehi 846 14 stress stress NN cord-335975-m6lkrehi 846 15 ( ( -LRB- cord-335975-m6lkrehi 846 16 declared declare VBD cord-335975-m6lkrehi 846 17 VAS VAS NNP cord-335975-m6lkrehi 846 18 stress stress NN cord-335975-m6lkrehi 846 19 ) ) -RRB- cord-335975-m6lkrehi 846 20 of of IN cord-335975-m6lkrehi 846 21 initial initial JJ cord-335975-m6lkrehi 846 22 antibiotic antibiotic JJ cord-335975-m6lkrehi 846 23 prescription prescription NN cord-335975-m6lkrehi 846 24 by by IN cord-335975-m6lkrehi 846 25 ICU ICU NNP cord-335975-m6lkrehi 846 26 clinicians clinician NNS cord-335975-m6lkrehi 846 27 , , , cord-335975-m6lkrehi 847 1 ANTIBIOGARDE ANTIBIOGARDE NNP cord-335975-m6lkrehi 847 2 ® ® POS cord-335975-m6lkrehi 847 3 proposal proposal NN cord-335975-m6lkrehi 847 4 and and CC cord-335975-m6lkrehi 847 5 national national JJ cord-335975-m6lkrehi 847 6 or or CC cord-335975-m6lkrehi 847 7 international international JJ cord-335975-m6lkrehi 847 8 guidelines guideline NNS cord-335975-m6lkrehi 847 9 . . . cord-335975-m6lkrehi 848 1 Patients patient NNS cord-335975-m6lkrehi 848 2 and and CC cord-335975-m6lkrehi 848 3 methods method NNS cord-335975-m6lkrehi 848 4 : : : cord-335975-m6lkrehi 848 5 Between between IN cord-335975-m6lkrehi 848 6 January January NNP cord-335975-m6lkrehi 848 7 and and CC cord-335975-m6lkrehi 848 8 June June NNP cord-335975-m6lkrehi 848 9 2016 2016 CD cord-335975-m6lkrehi 848 10 , , , cord-335975-m6lkrehi 848 11 initial initial JJ cord-335975-m6lkrehi 848 12 antibiotic antibiotic JJ cord-335975-m6lkrehi 848 13 prescriptions prescription NNS cord-335975-m6lkrehi 848 14 in in IN cord-335975-m6lkrehi 848 15 an an DT cord-335975-m6lkrehi 848 16 ICU ICU NNP cord-335975-m6lkrehi 848 17 were be VBD cord-335975-m6lkrehi 848 18 retrospectively retrospectively RB cord-335975-m6lkrehi 848 19 analyzed analyze VBN cord-335975-m6lkrehi 848 20 when when WRB cord-335975-m6lkrehi 848 21 microbiologically microbiologically RB cord-335975-m6lkrehi 848 22 documented document VBN cord-335975-m6lkrehi 848 23 . . . cord-335975-m6lkrehi 849 1 ANTIBIOGARDE ANTIBIOGARDE NNP cord-335975-m6lkrehi 849 2 ® ® . cord-335975-m6lkrehi 849 3 and and CC cord-335975-m6lkrehi 849 4 guidelines guideline NNS cord-335975-m6lkrehi 849 5 proposals proposal NNS cord-335975-m6lkrehi 849 6 were be VBD cord-335975-m6lkrehi 849 7 simulated simulate VBN cord-335975-m6lkrehi 849 8 , , , cord-335975-m6lkrehi 849 9 considering consider VBG cord-335975-m6lkrehi 849 10 data datum NNS cord-335975-m6lkrehi 849 11 available available JJ cord-335975-m6lkrehi 849 12 at at IN cord-335975-m6lkrehi 849 13 the the DT cord-335975-m6lkrehi 849 14 time time NN cord-335975-m6lkrehi 849 15 of of IN cord-335975-m6lkrehi 849 16 initial initial JJ cord-335975-m6lkrehi 849 17 prescription prescription NN cord-335975-m6lkrehi 849 18 . . . cord-335975-m6lkrehi 850 1 Adequacy adequacy NN cord-335975-m6lkrehi 850 2 was be VBD cord-335975-m6lkrehi 850 3 defined define VBN cord-335975-m6lkrehi 850 4 when when WRB cord-335975-m6lkrehi 850 5 all all DT cord-335975-m6lkrehi 850 6 bacteria bacteria NNS cord-335975-m6lkrehi 850 7 responsible responsible JJ cord-335975-m6lkrehi 850 8 for for IN cord-335975-m6lkrehi 850 9 infection infection NN cord-335975-m6lkrehi 850 10 were be VBD cord-335975-m6lkrehi 850 11 sensitive sensitive JJ cord-335975-m6lkrehi 850 12 to to IN cord-335975-m6lkrehi 850 13 at at RB cord-335975-m6lkrehi 850 14 least least RBS cord-335975-m6lkrehi 850 15 one one CD cord-335975-m6lkrehi 850 16 prescribed prescribe VBN cord-335975-m6lkrehi 850 17 proposed propose VBN cord-335975-m6lkrehi 850 18 antibiotic antibiotic NN cord-335975-m6lkrehi 850 19 . . . cord-335975-m6lkrehi 851 1 National national JJ cord-335975-m6lkrehi 851 2 guidelines guideline NNS cord-335975-m6lkrehi 851 3 were be VBD cord-335975-m6lkrehi 851 4 used use VBN cord-335975-m6lkrehi 851 5 when when WRB cord-335975-m6lkrehi 851 6 published publish VBN cord-335975-m6lkrehi 851 7 after after IN cord-335975-m6lkrehi 851 8 2011 2011 CD cord-335975-m6lkrehi 851 9 . . . cord-335975-m6lkrehi 852 1 Otherwise otherwise RB cord-335975-m6lkrehi 852 2 , , , cord-335975-m6lkrehi 852 3 most most RBS cord-335975-m6lkrehi 852 4 recent recent JJ cord-335975-m6lkrehi 852 5 international international JJ cord-335975-m6lkrehi 852 6 guidelines guideline NNS cord-335975-m6lkrehi 852 7 were be VBD cord-335975-m6lkrehi 852 8 used use VBN cord-335975-m6lkrehi 852 9 . . . cord-335975-m6lkrehi 853 1 Results result NNS cord-335975-m6lkrehi 853 2 : : : cord-335975-m6lkrehi 854 1 120 120 CD cord-335975-m6lkrehi 854 2 initial initial JJ cord-335975-m6lkrehi 854 3 prescriptions prescription NNS cord-335975-m6lkrehi 854 4 were be VBD cord-335975-m6lkrehi 854 5 analyzed analyze VBN cord-335975-m6lkrehi 854 6 ( ( -LRB- cord-335975-m6lkrehi 854 7 45 45 CD cord-335975-m6lkrehi 854 8 monotherapy monotherapy NN cord-335975-m6lkrehi 854 9 ) ) -RRB- cord-335975-m6lkrehi 854 10 in in IN cord-335975-m6lkrehi 854 11 97 97 CD cord-335975-m6lkrehi 854 12 patients patient NNS cord-335975-m6lkrehi 854 13 ( ( -LRB- cord-335975-m6lkrehi 854 14 median median JJ cord-335975-m6lkrehi 854 15 age age NN cord-335975-m6lkrehi 854 16 63y 63y NNS cord-335975-m6lkrehi 854 17 , , , cord-335975-m6lkrehi 854 18 median median JJ cord-335975-m6lkrehi 854 19 SAPS SAPS NNP cord-335975-m6lkrehi 854 20 II II NNP cord-335975-m6lkrehi 854 21 53 53 CD cord-335975-m6lkrehi 854 22 , , , cord-335975-m6lkrehi 854 23 median median JJ cord-335975-m6lkrehi 854 24 SOFA sofa NN cord-335975-m6lkrehi 854 25 on on IN cord-335975-m6lkrehi 854 26 prescription prescription NN cord-335975-m6lkrehi 854 27 7 7 CD cord-335975-m6lkrehi 854 28 , , , cord-335975-m6lkrehi 854 29 ICU ICU NNP cord-335975-m6lkrehi 854 30 mortality mortality NN cord-335975-m6lkrehi 854 31 41 41 CD cord-335975-m6lkrehi 854 32 % % NN cord-335975-m6lkrehi 854 33 , , , cord-335975-m6lkrehi 854 34 17 17 CD cord-335975-m6lkrehi 854 35 % % NN cord-335975-m6lkrehi 854 36 immunocompromised immunocompromised JJ cord-335975-m6lkrehi 854 37 ) ) -RRB- cord-335975-m6lkrehi 854 38 . . . cord-335975-m6lkrehi 855 1 Main main JJ cord-335975-m6lkrehi 855 2 sources source NNS cord-335975-m6lkrehi 855 3 of of IN cord-335975-m6lkrehi 855 4 infection infection NN cord-335975-m6lkrehi 855 5 were be VBD cord-335975-m6lkrehi 855 6 lung lung NN cord-335975-m6lkrehi 855 7 ( ( -LRB- cord-335975-m6lkrehi 855 8 n n NN cord-335975-m6lkrehi 855 9 = = SYM cord-335975-m6lkrehi 855 10 75 75 CD cord-335975-m6lkrehi 855 11 ) ) -RRB- cord-335975-m6lkrehi 855 12 and and CC cord-335975-m6lkrehi 855 13 intra intra JJ cord-335975-m6lkrehi 855 14 - - JJ cord-335975-m6lkrehi 855 15 abdominal abdominal JJ cord-335975-m6lkrehi 855 16 ( ( -LRB- cord-335975-m6lkrehi 855 17 n n NN cord-335975-m6lkrehi 855 18 = = SYM cord-335975-m6lkrehi 855 19 23 23 CD cord-335975-m6lkrehi 855 20 ) ) -RRB- cord-335975-m6lkrehi 855 21 . . . cord-335975-m6lkrehi 856 1 Leading lead VBG cord-335975-m6lkrehi 856 2 isolated isolate VBN cord-335975-m6lkrehi 856 3 bacteria bacteria NNS cord-335975-m6lkrehi 856 4 were be VBD cord-335975-m6lkrehi 856 5 Enterobacteriaceae Enterobacteriaceae NNP cord-335975-m6lkrehi 856 6 ( ( -LRB- cord-335975-m6lkrehi 856 7 n n NN cord-335975-m6lkrehi 856 8 = = SYM cord-335975-m6lkrehi 856 9 67 67 CD cord-335975-m6lkrehi 856 10 , , , cord-335975-m6lkrehi 856 11 antibiotic antibiotic JJ cord-335975-m6lkrehi 856 12 resistance resistance NN cord-335975-m6lkrehi 856 13 in in IN cord-335975-m6lkrehi 856 14 14 14 CD cord-335975-m6lkrehi 856 15 ) ) -RRB- cord-335975-m6lkrehi 856 16 , , , cord-335975-m6lkrehi 856 17 Streptococci Streptococci NNP cord-335975-m6lkrehi 856 18 ( ( -LRB- cord-335975-m6lkrehi 856 19 n n NN cord-335975-m6lkrehi 856 20 = = SYM cord-335975-m6lkrehi 856 21 55 55 CD cord-335975-m6lkrehi 856 22 ) ) -RRB- cord-335975-m6lkrehi 856 23 , , , cord-335975-m6lkrehi 856 24 non non JJ cord-335975-m6lkrehi 856 25 - - JJ cord-335975-m6lkrehi 856 26 fermenting fermenting JJ cord-335975-m6lkrehi 856 27 Gram Gram NNP cord-335975-m6lkrehi 856 28 negative negative JJ cord-335975-m6lkrehi 856 29 bacilli bacilli NN cord-335975-m6lkrehi 856 30 ( ( -LRB- cord-335975-m6lkrehi 856 31 n n NN cord-335975-m6lkrehi 856 32 = = SYM cord-335975-m6lkrehi 856 33 27 27 CD cord-335975-m6lkrehi 856 34 , , , cord-335975-m6lkrehi 856 35 antibiotic antibiotic JJ cord-335975-m6lkrehi 856 36 resistance resistance NN cord-335975-m6lkrehi 856 37 in in IN cord-335975-m6lkrehi 856 38 12 12 CD cord-335975-m6lkrehi 856 39 ) ) -RRB- cord-335975-m6lkrehi 856 40 and and CC cord-335975-m6lkrehi 856 41 Staphylococci Staphylococci NNP cord-335975-m6lkrehi 856 42 ( ( -LRB- cord-335975-m6lkrehi 856 43 n n NN cord-335975-m6lkrehi 856 44 = = SYM cord-335975-m6lkrehi 856 45 25 25 CD cord-335975-m6lkrehi 856 46 , , , cord-335975-m6lkrehi 856 47 resistance resistance NN cord-335975-m6lkrehi 856 48 to to IN cord-335975-m6lkrehi 856 49 methicillin methicillin NN cord-335975-m6lkrehi 856 50 in in IN cord-335975-m6lkrehi 856 51 5 5 CD cord-335975-m6lkrehi 856 52 ) ) -RRB- cord-335975-m6lkrehi 856 53 . . . cord-335975-m6lkrehi 857 1 In in IN cord-335975-m6lkrehi 857 2 the the DT cord-335975-m6lkrehi 857 3 120 120 CD cord-335975-m6lkrehi 857 4 clinical clinical JJ cord-335975-m6lkrehi 857 5 settings setting NNS cord-335975-m6lkrehi 857 6 analyzed analyze VBN cord-335975-m6lkrehi 857 7 , , , cord-335975-m6lkrehi 857 8 there there EX cord-335975-m6lkrehi 857 9 was be VBD cord-335975-m6lkrehi 857 10 a a DT cord-335975-m6lkrehi 857 11 proposal proposal NN cord-335975-m6lkrehi 857 12 by by IN cord-335975-m6lkrehi 858 1 ANTIOGARDE ANTIOGARDE NNP cord-335975-m6lkrehi 858 2 ® ® VBZ cord-335975-m6lkrehi 858 3 in in IN cord-335975-m6lkrehi 858 4 97 97 CD cord-335975-m6lkrehi 858 5 ( ( -LRB- cord-335975-m6lkrehi 858 6 81 81 CD cord-335975-m6lkrehi 858 7 % % NN cord-335975-m6lkrehi 858 8 ) ) -RRB- cord-335975-m6lkrehi 858 9 and and CC cord-335975-m6lkrehi 858 10 a a DT cord-335975-m6lkrehi 858 11 guideline guideline NN cord-335975-m6lkrehi 858 12 available available JJ cord-335975-m6lkrehi 858 13 in in IN cord-335975-m6lkrehi 858 14 102 102 CD cord-335975-m6lkrehi 858 15 ( ( -LRB- cord-335975-m6lkrehi 858 16 85 85 CD cord-335975-m6lkrehi 858 17 % % NN cord-335975-m6lkrehi 858 18 ) ) -RRB- cord-335975-m6lkrehi 859 1 ( ( -LRB- cord-335975-m6lkrehi 859 2 p p NN cord-335975-m6lkrehi 859 3 = = SYM cord-335975-m6lkrehi 859 4 0.39 0.39 CD cord-335975-m6lkrehi 859 5 Introduction introduction NN cord-335975-m6lkrehi 859 6 : : : cord-335975-m6lkrehi 860 1 Intubation intubation NN cord-335975-m6lkrehi 860 2 is be VBZ cord-335975-m6lkrehi 860 3 plagued plague VBN cord-335975-m6lkrehi 860 4 with with IN cord-335975-m6lkrehi 860 5 a a DT cord-335975-m6lkrehi 860 6 high high JJ cord-335975-m6lkrehi 860 7 morbimortality morbimortality NN cord-335975-m6lkrehi 860 8 , , , cord-335975-m6lkrehi 860 9 especially especially RB cord-335975-m6lkrehi 860 10 in in IN cord-335975-m6lkrehi 860 11 emergency emergency NN cord-335975-m6lkrehi 860 12 situations situation NNS cord-335975-m6lkrehi 860 13 . . . cord-335975-m6lkrehi 861 1 It -PRON- PRP cord-335975-m6lkrehi 861 2 is be VBZ cord-335975-m6lkrehi 861 3 now now RB cord-335975-m6lkrehi 861 4 acknowledged acknowledge VBN cord-335975-m6lkrehi 861 5 that that IN cord-335975-m6lkrehi 861 6 a a DT cord-335975-m6lkrehi 861 7 seated seated JJ cord-335975-m6lkrehi 861 8 position position NN cord-335975-m6lkrehi 861 9 allows allow VBZ cord-335975-m6lkrehi 861 10 for for IN cord-335975-m6lkrehi 861 11 optimized optimize VBN cord-335975-m6lkrehi 861 12 preoxygenation preoxygenation NN cord-335975-m6lkrehi 861 13 ( ( -LRB- cord-335975-m6lkrehi 861 14 1 1 CD cord-335975-m6lkrehi 861 15 ) ) -RRB- cord-335975-m6lkrehi 861 16 . . . cord-335975-m6lkrehi 862 1 However however RB cord-335975-m6lkrehi 862 2 , , , cord-335975-m6lkrehi 862 3 there there EX cord-335975-m6lkrehi 862 4 is be VBZ cord-335975-m6lkrehi 862 5 no no DT cord-335975-m6lkrehi 862 6 guideline guideline NN cord-335975-m6lkrehi 862 7 concerning concern VBG cord-335975-m6lkrehi 862 8 the the DT cord-335975-m6lkrehi 862 9 patient patient NN cord-335975-m6lkrehi 862 10 's 's POS cord-335975-m6lkrehi 862 11 position position NN cord-335975-m6lkrehi 862 12 for for IN cord-335975-m6lkrehi 862 13 intubation intubation NN cord-335975-m6lkrehi 862 14 . . . cord-335975-m6lkrehi 863 1 The the DT cord-335975-m6lkrehi 863 2 patient patient NN cord-335975-m6lkrehi 863 3 is be VBZ cord-335975-m6lkrehi 863 4 most most RBS cord-335975-m6lkrehi 863 5 often often RB cord-335975-m6lkrehi 863 6 laid lay VBN cord-335975-m6lkrehi 863 7 in in IN cord-335975-m6lkrehi 863 8 a a DT cord-335975-m6lkrehi 863 9 supine supine JJ cord-335975-m6lkrehi 863 10 position position NN cord-335975-m6lkrehi 863 11 , , , cord-335975-m6lkrehi 863 12 leading lead VBG cord-335975-m6lkrehi 863 13 to to IN cord-335975-m6lkrehi 863 14 a a DT cord-335975-m6lkrehi 863 15 higher high JJR cord-335975-m6lkrehi 863 16 risk risk NN cord-335975-m6lkrehi 863 17 of of IN cord-335975-m6lkrehi 863 18 aspiration aspiration NN cord-335975-m6lkrehi 863 19 ( ( -LRB- cord-335975-m6lkrehi 863 20 2 2 CD cord-335975-m6lkrehi 863 21 ) ) -RRB- cord-335975-m6lkrehi 863 22 . . . cord-335975-m6lkrehi 864 1 Face face NN cord-335975-m6lkrehi 864 2 - - HYPH cord-335975-m6lkrehi 864 3 to to IN cord-335975-m6lkrehi 864 4 - - HYPH cord-335975-m6lkrehi 864 5 face face NN cord-335975-m6lkrehi 864 6 intubation intubation NN cord-335975-m6lkrehi 864 7 in in IN cord-335975-m6lkrehi 864 8 sitting sit VBG cord-335975-m6lkrehi 864 9 position position NN cord-335975-m6lkrehi 864 10 ( ( -LRB- cord-335975-m6lkrehi 864 11 FtFi FtFi NNP cord-335975-m6lkrehi 864 12 ) ) -RRB- cord-335975-m6lkrehi 864 13 would would MD cord-335975-m6lkrehi 864 14 allow allow VB cord-335975-m6lkrehi 864 15 for for IN cord-335975-m6lkrehi 864 16 an an DT cord-335975-m6lkrehi 864 17 easier easy JJR cord-335975-m6lkrehi 864 18 intubation intubation NN cord-335975-m6lkrehi 864 19 and and CC cord-335975-m6lkrehi 864 20 a a DT cord-335975-m6lkrehi 864 21 lower low JJR cord-335975-m6lkrehi 864 22 morbidity morbidity NN cord-335975-m6lkrehi 864 23 . . . cord-335975-m6lkrehi 865 1 We -PRON- PRP cord-335975-m6lkrehi 865 2 focused focus VBD cord-335975-m6lkrehi 865 3 on on IN cord-335975-m6lkrehi 865 4 learning learn VBG cord-335975-m6lkrehi 865 5 the the DT cord-335975-m6lkrehi 865 6 FtFi FtFi NNP cord-335975-m6lkrehi 865 7 technique technique NN cord-335975-m6lkrehi 865 8 using use VBG cord-335975-m6lkrehi 865 9 the the DT cord-335975-m6lkrehi 865 10 Macintosh Macintosh NNP cord-335975-m6lkrehi 865 11 laryngoscope laryngoscope NN cord-335975-m6lkrehi 865 12 and and CC cord-335975-m6lkrehi 865 13 the the DT cord-335975-m6lkrehi 865 14 Airtraq Airtraq NNP cord-335975-m6lkrehi 865 15 videolaryngoscope videolaryngoscope NN cord-335975-m6lkrehi 865 16 in in IN cord-335975-m6lkrehi 865 17 simulated simulated JJ cord-335975-m6lkrehi 865 18 difficult difficult JJ cord-335975-m6lkrehi 865 19 intubation intubation NN cord-335975-m6lkrehi 865 20 situation situation NN cord-335975-m6lkrehi 865 21 and and CC cord-335975-m6lkrehi 865 22 comparing compare VBG cord-335975-m6lkrehi 865 23 the the DT cord-335975-m6lkrehi 865 24 performance performance NN cord-335975-m6lkrehi 865 25 of of IN cord-335975-m6lkrehi 865 26 the the DT cord-335975-m6lkrehi 865 27 FtFi FtFi NNP cord-335975-m6lkrehi 865 28 with with IN cord-335975-m6lkrehi 865 29 the the DT cord-335975-m6lkrehi 865 30 classic classic JJ cord-335975-m6lkrehi 865 31 technique technique NN cord-335975-m6lkrehi 865 32 . . . cord-335975-m6lkrehi 866 1 The the DT cord-335975-m6lkrehi 866 2 participants participant NNS cord-335975-m6lkrehi 866 3 would would MD cord-335975-m6lkrehi 866 4 intubate intubate VB cord-335975-m6lkrehi 866 5 a a DT cord-335975-m6lkrehi 866 6 high high JJ cord-335975-m6lkrehi 866 7 - - HYPH cord-335975-m6lkrehi 866 8 fidelity fidelity NN cord-335975-m6lkrehi 866 9 manikin manikin NN cord-335975-m6lkrehi 866 10 ( ( -LRB- cord-335975-m6lkrehi 866 11 SimMan3 SimMan3 NNP cord-335975-m6lkrehi 866 12 G G NNP cord-335975-m6lkrehi 866 13 , , , cord-335975-m6lkrehi 866 14 Leardal Leardal NNP cord-335975-m6lkrehi 866 15 , , , cord-335975-m6lkrehi 866 16 Norway Norway NNP cord-335975-m6lkrehi 866 17 ) ) -RRB- cord-335975-m6lkrehi 866 18 configured configure VBD cord-335975-m6lkrehi 866 19 with with IN cord-335975-m6lkrehi 866 20 a a DT cord-335975-m6lkrehi 866 21 tongue tongue NN cord-335975-m6lkrehi 866 22 edema edema NN cord-335975-m6lkrehi 866 23 ( ( -LRB- cord-335975-m6lkrehi 866 24 Cormack Cormack NNP cord-335975-m6lkrehi 866 25 2b-3 2b-3 CD cord-335975-m6lkrehi 866 26 ) ) -RRB- cord-335975-m6lkrehi 866 27 . . . cord-335975-m6lkrehi 867 1 For for IN cord-335975-m6lkrehi 867 2 each each DT cord-335975-m6lkrehi 867 3 trial trial NN cord-335975-m6lkrehi 867 4 , , , cord-335975-m6lkrehi 867 5 time time NN cord-335975-m6lkrehi 867 6 to to TO cord-335975-m6lkrehi 867 7 intubate intubate VB cord-335975-m6lkrehi 867 8 ( ( -LRB- cord-335975-m6lkrehi 867 9 TTI TTI NNP cord-335975-m6lkrehi 867 10 ) ) -RRB- cord-335975-m6lkrehi 867 11 , , , cord-335975-m6lkrehi 867 12 success success NN cord-335975-m6lkrehi 867 13 and and CC cord-335975-m6lkrehi 867 14 complication complication NN cord-335975-m6lkrehi 867 15 rate rate NN cord-335975-m6lkrehi 867 16 , , , cord-335975-m6lkrehi 867 17 intubation intubation NN cord-335975-m6lkrehi 867 18 difficulty difficulty NN cord-335975-m6lkrehi 867 19 and and CC cord-335975-m6lkrehi 867 20 glottis glottis NN cord-335975-m6lkrehi 867 21 exposure exposure NN cord-335975-m6lkrehi 867 22 were be VBD cord-335975-m6lkrehi 867 23 noted note VBN cord-335975-m6lkrehi 867 24 . . . cord-335975-m6lkrehi 868 1 In in IN cord-335975-m6lkrehi 868 2 classic classic JJ cord-335975-m6lkrehi 868 3 position position NN cord-335975-m6lkrehi 868 4 , , , cord-335975-m6lkrehi 868 5 three three CD cord-335975-m6lkrehi 868 6 trials trial NNS cord-335975-m6lkrehi 868 7 were be VBD cord-335975-m6lkrehi 868 8 performed perform VBN cord-335975-m6lkrehi 868 9 with with IN cord-335975-m6lkrehi 868 10 the the DT cord-335975-m6lkrehi 868 11 Airtraq Airtraq NNP cord-335975-m6lkrehi 868 12 followed follow VBN cord-335975-m6lkrehi 868 13 by by IN cord-335975-m6lkrehi 868 14 the the DT cord-335975-m6lkrehi 868 15 laryngoscope laryngoscope NN cord-335975-m6lkrehi 868 16 in in IN cord-335975-m6lkrehi 868 17 order order NN cord-335975-m6lkrehi 868 18 to to TO cord-335975-m6lkrehi 868 19 obtain obtain VB cord-335975-m6lkrehi 868 20 baseline baseline JJ cord-335975-m6lkrehi 868 21 parameters parameter NNS cord-335975-m6lkrehi 868 22 . . . cord-335975-m6lkrehi 869 1 In in IN cord-335975-m6lkrehi 869 2 FtFi FtFi NNP cord-335975-m6lkrehi 869 3 , , , cord-335975-m6lkrehi 869 4 at at RB cord-335975-m6lkrehi 869 5 least least JJS cord-335975-m6lkrehi 869 6 30 30 CD cord-335975-m6lkrehi 869 7 intubations intubation NNS cord-335975-m6lkrehi 869 8 were be VBD cord-335975-m6lkrehi 869 9 performed perform VBN cord-335975-m6lkrehi 869 10 by by IN cord-335975-m6lkrehi 869 11 each each DT cord-335975-m6lkrehi 869 12 participant participant NN cord-335975-m6lkrehi 869 13 for for IN cord-335975-m6lkrehi 869 14 each each DT cord-335975-m6lkrehi 869 15 device device NN cord-335975-m6lkrehi 869 16 . . . cord-335975-m6lkrehi 870 1 The the DT cord-335975-m6lkrehi 870 2 utilization utilization NN cord-335975-m6lkrehi 870 3 order order NN cord-335975-m6lkrehi 870 4 was be VBD cord-335975-m6lkrehi 870 5 randomized randomize VBN cord-335975-m6lkrehi 870 6 . . . cord-335975-m6lkrehi 871 1 Results result NNS cord-335975-m6lkrehi 871 2 : : : cord-335975-m6lkrehi 872 1 Thirty thirty CD cord-335975-m6lkrehi 872 2 physicians physician NNS cord-335975-m6lkrehi 872 3 , , , cord-335975-m6lkrehi 872 4 with with IN cord-335975-m6lkrehi 872 5 an an DT cord-335975-m6lkrehi 872 6 experience experience NN cord-335975-m6lkrehi 872 7 of of IN cord-335975-m6lkrehi 872 8 at at RB cord-335975-m6lkrehi 872 9 least least RBS cord-335975-m6lkrehi 872 10 200 200 CD cord-335975-m6lkrehi 872 11 intubations intubation NNS cord-335975-m6lkrehi 872 12 each each DT cord-335975-m6lkrehi 872 13 , , , cord-335975-m6lkrehi 872 14 were be VBD cord-335975-m6lkrehi 872 15 included include VBN cord-335975-m6lkrehi 872 16 . . . cord-335975-m6lkrehi 873 1 Figure figure NN cord-335975-m6lkrehi 873 2 shows show VBZ cord-335975-m6lkrehi 873 3 the the DT cord-335975-m6lkrehi 873 4 learning learning NN cord-335975-m6lkrehi 873 5 curves curve NNS cord-335975-m6lkrehi 873 6 of of IN cord-335975-m6lkrehi 873 7 the the DT cord-335975-m6lkrehi 873 8 FtFi FtFi NNP cord-335975-m6lkrehi 873 9 based base VBN cord-335975-m6lkrehi 873 10 on on IN cord-335975-m6lkrehi 873 11 the the DT cord-335975-m6lkrehi 873 12 evolution evolution NN cord-335975-m6lkrehi 873 13 of of IN cord-335975-m6lkrehi 873 14 the the DT cord-335975-m6lkrehi 873 15 TTI TTI NNP cord-335975-m6lkrehi 873 16 measured measure VBN cord-335975-m6lkrehi 873 17 for for IN cord-335975-m6lkrehi 873 18 the the DT cord-335975-m6lkrehi 873 19 Airtraq Airtraq NNP cord-335975-m6lkrehi 873 20 and and CC cord-335975-m6lkrehi 873 21 the the DT cord-335975-m6lkrehi 873 22 laryngoscope laryngoscope NN cord-335975-m6lkrehi 873 23 . . . cord-335975-m6lkrehi 874 1 In in IN cord-335975-m6lkrehi 874 2 classic classic JJ cord-335975-m6lkrehi 874 3 position position NN cord-335975-m6lkrehi 874 4 , , , cord-335975-m6lkrehi 874 5 the the DT cord-335975-m6lkrehi 874 6 mean mean JJ cord-335975-m6lkrehi 874 7 TTI TTI NNP cord-335975-m6lkrehi 874 8 with with IN cord-335975-m6lkrehi 874 9 the the DT cord-335975-m6lkrehi 874 10 Airtraq Airtraq NNP cord-335975-m6lkrehi 874 11 was be VBD cord-335975-m6lkrehi 874 12 30.5 30.5 CD cord-335975-m6lkrehi 874 13 ± ± NNP cord-335975-m6lkrehi 874 14 19.1 19.1 CD cord-335975-m6lkrehi 874 15 s s NNPS cord-335975-m6lkrehi 874 16 versus versus IN cord-335975-m6lkrehi 874 17 27.3 27.3 CD cord-335975-m6lkrehi 874 18 ± ± CD cord-335975-m6lkrehi 874 19 16.7 16.7 CD cord-335975-m6lkrehi 874 20 s s NNS cord-335975-m6lkrehi 874 21 with with IN cord-335975-m6lkrehi 874 22 the the DT cord-335975-m6lkrehi 874 23 laryngoscope laryngoscope NN cord-335975-m6lkrehi 874 24 ( ( -LRB- cord-335975-m6lkrehi 874 25 p p NN cord-335975-m6lkrehi 874 26 = = SYM cord-335975-m6lkrehi 874 27 ns ns NNP cord-335975-m6lkrehi 874 28 ) ) -RRB- cord-335975-m6lkrehi 874 29 . . . cord-335975-m6lkrehi 875 1 In in IN cord-335975-m6lkrehi 875 2 FtFi FtFi NNP cord-335975-m6lkrehi 875 3 , , , cord-335975-m6lkrehi 875 4 once once RB cord-335975-m6lkrehi 875 5 the the DT cord-335975-m6lkrehi 875 6 technique technique NN cord-335975-m6lkrehi 875 7 mastered master VBN cord-335975-m6lkrehi 875 8 , , , cord-335975-m6lkrehi 875 9 the the DT cord-335975-m6lkrehi 875 10 TTI TTI NNP cord-335975-m6lkrehi 875 11 was be VBD cord-335975-m6lkrehi 875 12 14 14 CD cord-335975-m6lkrehi 875 13 ± ± CD cord-335975-m6lkrehi 875 14 2.9 2.9 CD cord-335975-m6lkrehi 875 15 s s NNS cord-335975-m6lkrehi 875 16 with with IN cord-335975-m6lkrehi 875 17 the the DT cord-335975-m6lkrehi 875 18 Airtraq Airtraq NNP cord-335975-m6lkrehi 875 19 versus versus IN cord-335975-m6lkrehi 875 20 17.5 17.5 CD cord-335975-m6lkrehi 875 21 ± ± CD cord-335975-m6lkrehi 875 22 2.4 2.4 CD cord-335975-m6lkrehi 875 23 s s NNPS cord-335975-m6lkrehi 875 24 with with IN cord-335975-m6lkrehi 875 25 the the DT cord-335975-m6lkrehi 875 26 laryngoscope laryngoscope NN cord-335975-m6lkrehi 875 27 ( ( -LRB- cord-335975-m6lkrehi 875 28 p p NN cord-335975-m6lkrehi 875 29 < < XX cord-335975-m6lkrehi 875 30 0.05 0.05 CD cord-335975-m6lkrehi 875 31 ) ) -RRB- cord-335975-m6lkrehi 875 32 . . . cord-335975-m6lkrehi 876 1 Success success NN cord-335975-m6lkrehi 876 2 rate rate NN cord-335975-m6lkrehi 876 3 , , , cord-335975-m6lkrehi 876 4 TTI TTI NNP cord-335975-m6lkrehi 876 5 , , , cord-335975-m6lkrehi 876 6 complication complication NN cord-335975-m6lkrehi 876 7 rate rate NN cord-335975-m6lkrehi 876 8 , , , cord-335975-m6lkrehi 876 9 intubation intubation NN cord-335975-m6lkrehi 876 10 difficulty difficulty NN cord-335975-m6lkrehi 876 11 and and CC cord-335975-m6lkrehi 876 12 glottis glottis NN cord-335975-m6lkrehi 876 13 exposure exposure NN cord-335975-m6lkrehi 876 14 were be VBD cord-335975-m6lkrehi 876 15 better well JJR cord-335975-m6lkrehi 876 16 using use VBG cord-335975-m6lkrehi 876 17 FtFi FtFi NNP cord-335975-m6lkrehi 876 18 versus versus IN cord-335975-m6lkrehi 876 19 classic classic JJ cord-335975-m6lkrehi 876 20 intubation intubation NN cord-335975-m6lkrehi 876 21 ( ( -LRB- cord-335975-m6lkrehi 876 22 p p NN cord-335975-m6lkrehi 876 23 < < XX cord-335975-m6lkrehi 876 24 0.05 0.05 CD cord-335975-m6lkrehi 876 25 ) ) -RRB- cord-335975-m6lkrehi 876 26 . . . cord-335975-m6lkrehi 877 1 These these DT cord-335975-m6lkrehi 877 2 parameters parameter NNS cord-335975-m6lkrehi 877 3 were be VBD cord-335975-m6lkrehi 877 4 even even RB cord-335975-m6lkrehi 877 5 better well JJR cord-335975-m6lkrehi 877 6 with with IN cord-335975-m6lkrehi 877 7 the the DT cord-335975-m6lkrehi 877 8 Airtraq Airtraq NNP cord-335975-m6lkrehi 877 9 than than IN cord-335975-m6lkrehi 877 10 with with IN cord-335975-m6lkrehi 877 11 the the DT cord-335975-m6lkrehi 877 12 laryngoscope laryngoscope NN cord-335975-m6lkrehi 877 13 ( ( -LRB- cord-335975-m6lkrehi 877 14 p p NN cord-335975-m6lkrehi 877 15 < < XX cord-335975-m6lkrehi 877 16 0.05 0.05 CD cord-335975-m6lkrehi 877 17 ) ) -RRB- cord-335975-m6lkrehi 877 18 . . . cord-335975-m6lkrehi 878 1 The the DT cord-335975-m6lkrehi 878 2 learning learning NN cord-335975-m6lkrehi 878 3 profile profile NN cord-335975-m6lkrehi 878 4 of of IN cord-335975-m6lkrehi 878 5 FtFi FtFi NNP cord-335975-m6lkrehi 878 6 is be VBZ cord-335975-m6lkrehi 878 7 different different JJ cord-335975-m6lkrehi 878 8 between between IN cord-335975-m6lkrehi 878 9 the the DT cord-335975-m6lkrehi 878 10 Airtraq Airtraq NNP cord-335975-m6lkrehi 878 11 and and CC cord-335975-m6lkrehi 878 12 the the DT cord-335975-m6lkrehi 878 13 laryngoscope laryngoscope NN cord-335975-m6lkrehi 878 14 . . . cord-335975-m6lkrehi 879 1 It -PRON- PRP cord-335975-m6lkrehi 879 2 could could MD cord-335975-m6lkrehi 879 3 be be VB cord-335975-m6lkrehi 879 4 due due JJ cord-335975-m6lkrehi 879 5 to to IN cord-335975-m6lkrehi 879 6 the the DT cord-335975-m6lkrehi 879 7 participants participant NNS cord-335975-m6lkrehi 879 8 ' ' POS cord-335975-m6lkrehi 879 9 lesser less JJR cord-335975-m6lkrehi 879 10 familiarity familiarity NN cord-335975-m6lkrehi 879 11 with with IN cord-335975-m6lkrehi 879 12 the the DT cord-335975-m6lkrehi 879 13 Airtraq Airtraq NNP cord-335975-m6lkrehi 879 14 . . . cord-335975-m6lkrehi 880 1 The the DT cord-335975-m6lkrehi 880 2 better well JJR cord-335975-m6lkrehi 880 3 performances performance NNS cord-335975-m6lkrehi 880 4 in in IN cord-335975-m6lkrehi 880 5 FtFi FtFi NNP cord-335975-m6lkrehi 880 6 could could MD cord-335975-m6lkrehi 880 7 be be VB cord-335975-m6lkrehi 880 8 due due JJ cord-335975-m6lkrehi 880 9 to to IN cord-335975-m6lkrehi 880 10 better well JJR cord-335975-m6lkrehi 880 11 ergonomics ergonomic NNS cord-335975-m6lkrehi 880 12 allowing allow VBG cord-335975-m6lkrehi 880 13 easier easy JJR cord-335975-m6lkrehi 880 14 glottis glottis NN cord-335975-m6lkrehi 880 15 exposure exposure NN cord-335975-m6lkrehi 880 16 and and CC cord-335975-m6lkrehi 880 17 learning learning NN cord-335975-m6lkrehi 880 18 ( ( -LRB- cord-335975-m6lkrehi 880 19 3 3 CD cord-335975-m6lkrehi 880 20 ) ) -RRB- cord-335975-m6lkrehi 880 21 . . . cord-335975-m6lkrehi 881 1 Conclusion conclusion NN cord-335975-m6lkrehi 881 2 : : : cord-335975-m6lkrehi 881 3 Face face NN cord-335975-m6lkrehi 881 4 - - HYPH cord-335975-m6lkrehi 881 5 to to IN cord-335975-m6lkrehi 881 6 - - HYPH cord-335975-m6lkrehi 881 7 face face NN cord-335975-m6lkrehi 881 8 intubation intubation NN cord-335975-m6lkrehi 881 9 in in IN cord-335975-m6lkrehi 881 10 sitting sit VBG cord-335975-m6lkrehi 881 11 position position NN cord-335975-m6lkrehi 881 12 is be VBZ cord-335975-m6lkrehi 881 13 easy easy JJ cord-335975-m6lkrehi 881 14 to to TO cord-335975-m6lkrehi 881 15 learn learn VB cord-335975-m6lkrehi 881 16 . . . cord-335975-m6lkrehi 882 1 It -PRON- PRP cord-335975-m6lkrehi 882 2 provides provide VBZ cord-335975-m6lkrehi 882 3 better well JJR cord-335975-m6lkrehi 882 4 performances performance NNS cord-335975-m6lkrehi 882 5 and and CC cord-335975-m6lkrehi 882 6 fewer few JJR cord-335975-m6lkrehi 882 7 complications complication NNS cord-335975-m6lkrehi 882 8 than than IN cord-335975-m6lkrehi 882 9 the the DT cord-335975-m6lkrehi 882 10 classic classic JJ cord-335975-m6lkrehi 882 11 intubation intubation NN cord-335975-m6lkrehi 882 12 technique technique NN cord-335975-m6lkrehi 882 13 which which WDT cord-335975-m6lkrehi 882 14 might may MD cord-335975-m6lkrehi 882 15 result result VB cord-335975-m6lkrehi 882 16 in in IN cord-335975-m6lkrehi 882 17 a a DT cord-335975-m6lkrehi 882 18 lower low JJR cord-335975-m6lkrehi 882 19 morbidity morbidity NN cord-335975-m6lkrehi 882 20 . . . cord-335975-m6lkrehi 883 1 The the DT cord-335975-m6lkrehi 883 2 Airtraq Airtraq NNP cord-335975-m6lkrehi 883 3 provides provide VBZ cord-335975-m6lkrehi 883 4 even even RB cord-335975-m6lkrehi 883 5 better well JJR cord-335975-m6lkrehi 883 6 results result NNS cord-335975-m6lkrehi 883 7 than than IN cord-335975-m6lkrehi 883 8 Macintosh Macintosh NNP cord-335975-m6lkrehi 883 9 laryngoscope laryngoscope NN cord-335975-m6lkrehi 883 10 . . . cord-335975-m6lkrehi 884 1 All all DT cord-335975-m6lkrehi 884 2 participants participant NNS cord-335975-m6lkrehi 884 3 recommend recommend VBP cord-335975-m6lkrehi 884 4 their -PRON- PRP$ cord-335975-m6lkrehi 884 5 colleagues colleague NNS cord-335975-m6lkrehi 884 6 to to TO cord-335975-m6lkrehi 884 7 be be VB cord-335975-m6lkrehi 884 8 trained train VBN cord-335975-m6lkrehi 884 9 in in IN cord-335975-m6lkrehi 884 10 face face NN cord-335975-m6lkrehi 884 11 - - HYPH cord-335975-m6lkrehi 884 12 toface toface NN cord-335975-m6lkrehi 884 13 intubation intubation NN cord-335975-m6lkrehi 884 14 . . . cord-335975-m6lkrehi 885 1 Among among IN cord-335975-m6lkrehi 885 2 non non JJ cord-335975-m6lkrehi 885 3 - - JJ cord-335975-m6lkrehi 885 4 invasive invasive JJ cord-335975-m6lkrehi 885 5 respiratory respiratory JJ cord-335975-m6lkrehi 885 6 support support NN cord-335975-m6lkrehi 885 7 , , , cord-335975-m6lkrehi 885 8 NIV NIV NNP cord-335975-m6lkrehi 885 9 with with IN cord-335975-m6lkrehi 885 10 bilevel bilevel JJ cord-335975-m6lkrehi 885 11 pressure pressure NN cord-335975-m6lkrehi 885 12 was be VBD cord-335975-m6lkrehi 885 13 the the DT cord-335975-m6lkrehi 885 14 most most RBS cord-335975-m6lkrehi 885 15 frequent frequent JJ cord-335975-m6lkrehi 885 16 ( ( -LRB- cord-335975-m6lkrehi 885 17 n n NN cord-335975-m6lkrehi 885 18 = = SYM cord-335975-m6lkrehi 885 19 68 68 CD cord-335975-m6lkrehi 885 20 , , , cord-335975-m6lkrehi 885 21 50 50 CD cord-335975-m6lkrehi 885 22 % % NN cord-335975-m6lkrehi 885 23 ) ) -RRB- cord-335975-m6lkrehi 885 24 before before IN cord-335975-m6lkrehi 885 25 CPAP CPAP NNP cord-335975-m6lkrehi 885 26 ( ( -LRB- cord-335975-m6lkrehi 885 27 n n NN cord-335975-m6lkrehi 885 28 = = SYM cord-335975-m6lkrehi 885 29 23 23 CD cord-335975-m6lkrehi 885 30 , , , cord-335975-m6lkrehi 885 31 17 17 CD cord-335975-m6lkrehi 885 32 % % NN cord-335975-m6lkrehi 885 33 ) ) -RRB- cord-335975-m6lkrehi 885 34 and and CC cord-335975-m6lkrehi 885 35 high high JJ cord-335975-m6lkrehi 885 36 flow flow NN cord-335975-m6lkrehi 885 37 oxygen oxygen NN cord-335975-m6lkrehi 886 1 ( ( -LRB- cord-335975-m6lkrehi 886 2 n n NN cord-335975-m6lkrehi 886 3 = = SYM cord-335975-m6lkrehi 886 4 21 21 CD cord-335975-m6lkrehi 886 5 , , , cord-335975-m6lkrehi 886 6 15 15 CD cord-335975-m6lkrehi 886 7 % % NN cord-335975-m6lkrehi 886 8 ) ) -RRB- cord-335975-m6lkrehi 886 9 . . . cord-335975-m6lkrehi 887 1 The the DT cord-335975-m6lkrehi 887 2 proportion proportion NN cord-335975-m6lkrehi 887 3 of of IN cord-335975-m6lkrehi 887 4 patients patient NNS cord-335975-m6lkrehi 887 5 on on IN cord-335975-m6lkrehi 887 6 NIV NIV NNP cord-335975-m6lkrehi 887 7 was be VBD cord-335975-m6lkrehi 887 8 up up RB cord-335975-m6lkrehi 887 9 to to TO cord-335975-m6lkrehi 887 10 71 71 CD cord-335975-m6lkrehi 887 11 % % NN cord-335975-m6lkrehi 887 12 in in IN cord-335975-m6lkrehi 887 13 the the DT cord-335975-m6lkrehi 887 14 centres centre NNS cord-335975-m6lkrehi 887 15 hosting host VBG cord-335975-m6lkrehi 887 16 more more JJR cord-335975-m6lkrehi 887 17 ACS ACS NNP cord-335975-m6lkrehi 887 18 patients patient NNS cord-335975-m6lkrehi 887 19 . . . cord-335975-m6lkrehi 888 1 Conclusion conclusion NN cord-335975-m6lkrehi 888 2 : : : cord-335975-m6lkrehi 889 1 Despite despite IN cord-335975-m6lkrehi 889 2 the the DT cord-335975-m6lkrehi 889 3 absence absence NN cord-335975-m6lkrehi 889 4 of of IN cord-335975-m6lkrehi 889 5 evidence evidence NN cord-335975-m6lkrehi 889 6 from from IN cord-335975-m6lkrehi 889 7 randomized randomized JJ cord-335975-m6lkrehi 889 8 controlled control VBN cord-335975-m6lkrehi 889 9 trials trial NNS cord-335975-m6lkrehi 889 10 NIV NIV NNP cord-335975-m6lkrehi 889 11 is be VBZ cord-335975-m6lkrehi 889 12 nowadays nowadays RB cord-335975-m6lkrehi 889 13 commonly commonly RB cord-335975-m6lkrehi 889 14 used use VBN cord-335975-m6lkrehi 889 15 in in IN cord-335975-m6lkrehi 889 16 PICU PICU NNP cord-335975-m6lkrehi 889 17 and and CC cord-335975-m6lkrehi 889 18 HDU HDU NNP cord-335975-m6lkrehi 889 19 for for IN cord-335975-m6lkrehi 889 20 SCD SCD NNP cord-335975-m6lkrehi 889 21 patients patient NNS cord-335975-m6lkrehi 889 22 with with IN cord-335975-m6lkrehi 889 23 ACS ACS NNP cord-335975-m6lkrehi 889 24 , , , cord-335975-m6lkrehi 889 25 especially especially RB cord-335975-m6lkrehi 889 26 in in IN cord-335975-m6lkrehi 889 27 centres centre NNS cord-335975-m6lkrehi 889 28 taking take VBG cord-335975-m6lkrehi 889 29 in in RP cord-335975-m6lkrehi 889 30 charge charge NN cord-335975-m6lkrehi 889 31 a a DT cord-335975-m6lkrehi 889 32 high high JJ cord-335975-m6lkrehi 889 33 number number NN cord-335975-m6lkrehi 889 34 of of IN cord-335975-m6lkrehi 889 35 SCD SCD NNP cord-335975-m6lkrehi 889 36 patients patient NNS cord-335975-m6lkrehi 889 37 . . . cord-335975-m6lkrehi 890 1 Future future JJ cord-335975-m6lkrehi 890 2 physiological physiological JJ cord-335975-m6lkrehi 890 3 studies study NNS cord-335975-m6lkrehi 890 4 and and CC cord-335975-m6lkrehi 890 5 randomized randomize VBN cord-335975-m6lkrehi 890 6 controlled control VBN cord-335975-m6lkrehi 890 7 trials trial NNS cord-335975-m6lkrehi 890 8 might may MD cord-335975-m6lkrehi 890 9 help help VB cord-335975-m6lkrehi 890 10 to to TO cord-335975-m6lkrehi 890 11 choose choose VB cord-335975-m6lkrehi 890 12 between between IN cord-335975-m6lkrehi 890 13 the the DT cord-335975-m6lkrehi 890 14 different different JJ cord-335975-m6lkrehi 890 15 ventilatory ventilatory JJ cord-335975-m6lkrehi 890 16 support support NN cord-335975-m6lkrehi 890 17 options option NNS cord-335975-m6lkrehi 890 18 for for IN cord-335975-m6lkrehi 890 19 ACS ACS NNP cord-335975-m6lkrehi 890 20 . . . cord-335975-m6lkrehi 891 1 In in IN cord-335975-m6lkrehi 891 2 transfused transfused JJ cord-335975-m6lkrehi 891 3 patients patient NNS cord-335975-m6lkrehi 891 4 , , , cord-335975-m6lkrehi 891 5 the the DT cord-335975-m6lkrehi 891 6 pre pre JJ cord-335975-m6lkrehi 891 7 - - JJ cord-335975-m6lkrehi 891 8 transfusion transfusion JJ cord-335975-m6lkrehi 891 9 hemoglobin hemoglobin NN cord-335975-m6lkrehi 891 10 was be VBD cord-335975-m6lkrehi 891 11 8.1 8.1 CD cord-335975-m6lkrehi 891 12 ( ( -LRB- cord-335975-m6lkrehi 891 13 7.5 7.5 CD cord-335975-m6lkrehi 891 14 - - SYM cord-335975-m6lkrehi 891 15 9.3 9.3 CD cord-335975-m6lkrehi 891 16 ) ) -RRB- cord-335975-m6lkrehi 892 1 g g NNP cord-335975-m6lkrehi 892 2 dL dl NN cord-335975-m6lkrehi 892 3 in in IN cord-335975-m6lkrehi 892 4 moderate moderate JJ cord-335975-m6lkrehi 892 5 PARDS PARDS NNP cord-335975-m6lkrehi 892 6 and and CC cord-335975-m6lkrehi 892 7 7.5 7.5 CD cord-335975-m6lkrehi 892 8 ( ( -LRB- cord-335975-m6lkrehi 892 9 6.9 6.9 CD cord-335975-m6lkrehi 892 10 - - SYM cord-335975-m6lkrehi 892 11 7.3 7.3 CD cord-335975-m6lkrehi 892 12 ) ) -RRB- cord-335975-m6lkrehi 893 1 g g NNP cord-335975-m6lkrehi 893 2 dL dl NN cord-335975-m6lkrehi 893 3 in in IN cord-335975-m6lkrehi 893 4 severe severe JJ cord-335975-m6lkrehi 893 5 PARDS PARDS NNP cord-335975-m6lkrehi 893 6 . . . cord-335975-m6lkrehi 894 1 The the DT cord-335975-m6lkrehi 894 2 evolution evolution NN cord-335975-m6lkrehi 894 3 of of IN cord-335975-m6lkrehi 894 4 hemoglobin hemoglobin NN cord-335975-m6lkrehi 894 5 , , , cord-335975-m6lkrehi 894 6 OSI OSI NNP cord-335975-m6lkrehi 894 7 , , , cord-335975-m6lkrehi 894 8 ScvO2 ScvO2 NNP cord-335975-m6lkrehi 894 9 and and CC cord-335975-m6lkrehi 894 10 lactate lactate NN cord-335975-m6lkrehi 894 11 after after IN cord-335975-m6lkrehi 894 12 the the DT cord-335975-m6lkrehi 894 13 transfusion transfusion NN cord-335975-m6lkrehi 894 14 is be VBZ cord-335975-m6lkrehi 894 15 reported report VBN cord-335975-m6lkrehi 894 16 in in IN cord-335975-m6lkrehi 894 17 the the DT cord-335975-m6lkrehi 894 18 Table Table NNP cord-335975-m6lkrehi 894 19 1 1 CD cord-335975-m6lkrehi 894 20 . . . cord-335975-m6lkrehi 895 1 In in IN cord-335975-m6lkrehi 895 2 our -PRON- PRP$ cord-335975-m6lkrehi 895 3 PICU PICU NNP cord-335975-m6lkrehi 895 4 , , , cord-335975-m6lkrehi 895 5 a a DT cord-335975-m6lkrehi 895 6 relatively relatively RB cord-335975-m6lkrehi 895 7 restrictive restrictive JJ cord-335975-m6lkrehi 895 8 policy policy NN cord-335975-m6lkrehi 895 9 of of IN cord-335975-m6lkrehi 895 10 RBC RBC NNP cord-335975-m6lkrehi 895 11 transfusion transfusion NN cord-335975-m6lkrehi 895 12 was be VBD cord-335975-m6lkrehi 895 13 observed observe VBN cord-335975-m6lkrehi 895 14 even even RB cord-335975-m6lkrehi 895 15 in in IN cord-335975-m6lkrehi 895 16 patients patient NNS cord-335975-m6lkrehi 895 17 with with IN cord-335975-m6lkrehi 895 18 severe severe JJ cord-335975-m6lkrehi 895 19 PARDS PARDS NNP cord-335975-m6lkrehi 895 20 . . . cord-335975-m6lkrehi 896 1 Decision decision NN cord-335975-m6lkrehi 896 2 to to TO cord-335975-m6lkrehi 896 3 transfuse transfuse VB cord-335975-m6lkrehi 896 4 seemed seem VBN cord-335975-m6lkrehi 896 5 associated associate VBN cord-335975-m6lkrehi 896 6 with with IN cord-335975-m6lkrehi 896 7 the the DT cord-335975-m6lkrehi 896 8 general general JJ cord-335975-m6lkrehi 896 9 severity severity NN cord-335975-m6lkrehi 896 10 status status NN cord-335975-m6lkrehi 896 11 of of IN cord-335975-m6lkrehi 896 12 the the DT cord-335975-m6lkrehi 896 13 patient patient NN cord-335975-m6lkrehi 896 14 and and CC cord-335975-m6lkrehi 896 15 with with IN cord-335975-m6lkrehi 896 16 the the DT cord-335975-m6lkrehi 896 17 hemoglobin hemoglobin NN cord-335975-m6lkrehi 896 18 level level NN cord-335975-m6lkrehi 896 19 . . . cord-335975-m6lkrehi 897 1 Further further JJ cord-335975-m6lkrehi 897 2 studies study NNS cord-335975-m6lkrehi 897 3 are be VBP cord-335975-m6lkrehi 897 4 needed need VBN cord-335975-m6lkrehi 897 5 to to TO cord-335975-m6lkrehi 897 6 explore explore VB cord-335975-m6lkrehi 897 7 the the DT cord-335975-m6lkrehi 897 8 generalizability generalizability NN cord-335975-m6lkrehi 897 9 of of IN cord-335975-m6lkrehi 897 10 these these DT cord-335975-m6lkrehi 897 11 findings finding NNS cord-335975-m6lkrehi 897 12 , , , cord-335975-m6lkrehi 897 13 and and CC cord-335975-m6lkrehi 897 14 to to TO cord-335975-m6lkrehi 897 15 investigate investigate VB cord-335975-m6lkrehi 897 16 the the DT cord-335975-m6lkrehi 897 17 impact impact NN cord-335975-m6lkrehi 897 18 of of IN cord-335975-m6lkrehi 897 19 transfusion transfusion NN cord-335975-m6lkrehi 897 20 on on IN cord-335975-m6lkrehi 897 21 oxygen oxygen NN cord-335975-m6lkrehi 897 22 transport transport NN cord-335975-m6lkrehi 897 23 consumption consumption NN cord-335975-m6lkrehi 897 24 balance balance NN cord-335975-m6lkrehi 897 25 in in IN cord-335975-m6lkrehi 897 26 pediatric pediatric JJ cord-335975-m6lkrehi 897 27 acute acute JJ cord-335975-m6lkrehi 897 28 respiratory respiratory JJ cord-335975-m6lkrehi 897 29 distress distress NN cord-335975-m6lkrehi 897 30 . . . cord-335975-m6lkrehi 898 1 Introduction introduction NN cord-335975-m6lkrehi 898 2 : : : cord-335975-m6lkrehi 899 1 Pharmacokinetic pharmacokinetic JJ cord-335975-m6lkrehi 899 2 parameters parameter NNS cord-335975-m6lkrehi 899 3 are be VBP cord-335975-m6lkrehi 899 4 altered alter VBN cord-335975-m6lkrehi 899 5 in in IN cord-335975-m6lkrehi 899 6 critically critically RB cord-335975-m6lkrehi 899 7 ill ill JJ cord-335975-m6lkrehi 899 8 patients patient NNS cord-335975-m6lkrehi 899 9 . . . cord-335975-m6lkrehi 900 1 For for IN cord-335975-m6lkrehi 900 2 instance instance NN cord-335975-m6lkrehi 900 3 , , , cord-335975-m6lkrehi 900 4 in in IN cord-335975-m6lkrehi 900 5 adult adult NN cord-335975-m6lkrehi 900 6 patients patient NNS cord-335975-m6lkrehi 900 7 , , , cord-335975-m6lkrehi 900 8 it -PRON- PRP cord-335975-m6lkrehi 900 9 has have VBZ cord-335975-m6lkrehi 900 10 been be VBN cord-335975-m6lkrehi 900 11 well well RB cord-335975-m6lkrehi 900 12 demonstrated demonstrate VBN cord-335975-m6lkrehi 900 13 that that IN cord-335975-m6lkrehi 900 14 augmented augment VBN cord-335975-m6lkrehi 900 15 renal renal JJ cord-335975-m6lkrehi 900 16 clearance clearance NN cord-335975-m6lkrehi 900 17 results result NNS cord-335975-m6lkrehi 900 18 in in IN cord-335975-m6lkrehi 900 19 subtherapeutic subtherapeutic JJ cord-335975-m6lkrehi 900 20 antibiotic antibiotic JJ cord-335975-m6lkrehi 900 21 concentrations concentration NNS cord-335975-m6lkrehi 900 22 . . . cord-335975-m6lkrehi 901 1 Our -PRON- PRP$ cord-335975-m6lkrehi 901 2 objectives objective NNS cord-335975-m6lkrehi 901 3 were be VBD cord-335975-m6lkrehi 901 4 to to TO cord-335975-m6lkrehi 901 5 build build VB cord-335975-m6lkrehi 901 6 a a DT cord-335975-m6lkrehi 901 7 pediatric pediatric JJ cord-335975-m6lkrehi 901 8 population population NN cord-335975-m6lkrehi 901 9 pharmacokinetic pharmacokinetic JJ cord-335975-m6lkrehi 901 10 model model NN cord-335975-m6lkrehi 901 11 for for IN cord-335975-m6lkrehi 901 12 Piperacillin Piperacillin NNP cord-335975-m6lkrehi 901 13 , , , cord-335975-m6lkrehi 901 14 in in IN cord-335975-m6lkrehi 901 15 order order NN cord-335975-m6lkrehi 901 16 to to TO cord-335975-m6lkrehi 901 17 optimize optimize VB cord-335975-m6lkrehi 901 18 individual individual JJ cord-335975-m6lkrehi 901 19 dosing dose VBG cord-335975-m6lkrehi 901 20 regimen regimen NN cord-335975-m6lkrehi 901 21 . . . cord-335975-m6lkrehi 902 1 Patients patient NNS cord-335975-m6lkrehi 902 2 and and CC cord-335975-m6lkrehi 902 3 methods method NNS cord-335975-m6lkrehi 902 4 : : : cord-335975-m6lkrehi 902 5 All all DT cord-335975-m6lkrehi 902 6 children child NNS cord-335975-m6lkrehi 902 7 admitted admit VBN cord-335975-m6lkrehi 902 8 in in IN cord-335975-m6lkrehi 902 9 pediatric pediatric JJ cord-335975-m6lkrehi 902 10 intensive intensive JJ cord-335975-m6lkrehi 902 11 care care NN cord-335975-m6lkrehi 902 12 unit unit NN cord-335975-m6lkrehi 902 13 , , , cord-335975-m6lkrehi 902 14 aged aged JJ cord-335975-m6lkrehi 902 15 less less JJR cord-335975-m6lkrehi 902 16 than than IN cord-335975-m6lkrehi 902 17 18 18 CD cord-335975-m6lkrehi 902 18 years year NNS cord-335975-m6lkrehi 902 19 , , , cord-335975-m6lkrehi 902 20 weighing weigh VBG cord-335975-m6lkrehi 902 21 more more JJR cord-335975-m6lkrehi 902 22 than than IN cord-335975-m6lkrehi 902 23 2.5 2.5 CD cord-335975-m6lkrehi 902 24 kg kg NNS cord-335975-m6lkrehi 902 25 , , , cord-335975-m6lkrehi 902 26 and and CC cord-335975-m6lkrehi 902 27 receiving receive VBG cord-335975-m6lkrehi 902 28 intermittent intermittent JJ cord-335975-m6lkrehi 902 29 Piperacillin Piperacillin NNP cord-335975-m6lkrehi 902 30 infusions infusion NNS cord-335975-m6lkrehi 902 31 were be VBD cord-335975-m6lkrehi 902 32 included include VBN cord-335975-m6lkrehi 902 33 . . . cord-335975-m6lkrehi 903 1 Piperacillin Piperacillin NNP cord-335975-m6lkrehi 903 2 was be VBD cord-335975-m6lkrehi 903 3 quantified quantify VBN cord-335975-m6lkrehi 903 4 by by IN cord-335975-m6lkrehi 903 5 high high JJ cord-335975-m6lkrehi 903 6 performance performance NN cord-335975-m6lkrehi 903 7 liquid liquid NN cord-335975-m6lkrehi 903 8 chromatography chromatography NN cord-335975-m6lkrehi 903 9 . . . cord-335975-m6lkrehi 904 1 Pharmacokinetics pharmacokinetic NNS cord-335975-m6lkrehi 904 2 were be VBD cord-335975-m6lkrehi 904 3 described describe VBN cord-335975-m6lkrehi 904 4 using use VBG cord-335975-m6lkrehi 904 5 the the DT cord-335975-m6lkrehi 904 6 non non JJ cord-335975-m6lkrehi 904 7 - - JJ cord-335975-m6lkrehi 904 8 linear linear JJ cord-335975-m6lkrehi 904 9 mixed mixed JJ cord-335975-m6lkrehi 904 10 effect effect NN cord-335975-m6lkrehi 904 11 modelling modelling NN cord-335975-m6lkrehi 904 12 software software NN cord-335975-m6lkrehi 904 13 MONOLIX MONOLIX NNP cord-335975-m6lkrehi 904 14 . . . cord-335975-m6lkrehi 905 1 Monte Monte NNP cord-335975-m6lkrehi 905 2 Carlo Carlo NNP cord-335975-m6lkrehi 905 3 simulations simulation NNS cord-335975-m6lkrehi 905 4 were be VBD cord-335975-m6lkrehi 905 5 used use VBN cord-335975-m6lkrehi 905 6 to to TO cord-335975-m6lkrehi 905 7 optimize optimize VB cord-335975-m6lkrehi 905 8 dosing dose VBG cord-335975-m6lkrehi 905 9 regimen regimen NN cord-335975-m6lkrehi 905 10 , , , cord-335975-m6lkrehi 905 11 in in IN cord-335975-m6lkrehi 905 12 order order NN cord-335975-m6lkrehi 905 13 to to TO cord-335975-m6lkrehi 905 14 maintain maintain VB cord-335975-m6lkrehi 905 15 plasma plasma NN cord-335975-m6lkrehi 905 16 concentration concentration NN cord-335975-m6lkrehi 905 17 above above IN cord-335975-m6lkrehi 905 18 the the DT cord-335975-m6lkrehi 905 19 minimum minimum JJ cord-335975-m6lkrehi 905 20 inhibitory inhibitory JJ cord-335975-m6lkrehi 905 21 concentration concentration NN cord-335975-m6lkrehi 905 22 ( ( -LRB- cord-335975-m6lkrehi 905 23 16 16 CD cord-335975-m6lkrehi 905 24 mg mg NNP cord-335975-m6lkrehi 905 25 L L NNP cord-335975-m6lkrehi 905 26 −1 −1 NNP cord-335975-m6lkrehi 905 27 for for IN cord-335975-m6lkrehi 905 28 Pseudomonas Pseudomonas NNP cord-335975-m6lkrehi 905 29 aeruginosa aeruginosa NN cord-335975-m6lkrehi 905 30 ) ) -RRB- cord-335975-m6lkrehi 905 31 throughout throughout IN cord-335975-m6lkrehi 905 32 the the DT cord-335975-m6lkrehi 905 33 dosing dosing NN cord-335975-m6lkrehi 905 34 interval interval NN cord-335975-m6lkrehi 905 35 ( ( -LRB- cord-335975-m6lkrehi 905 36 100 100 CD cord-335975-m6lkrehi 905 37 % % NN cord-335975-m6lkrehi 905 38 fT ft NN cord-335975-m6lkrehi 905 39 > > XX cord-335975-m6lkrehi 905 40 MIC mic NN cord-335975-m6lkrehi 905 41 ) ) -RRB- cord-335975-m6lkrehi 905 42 . . . cord-335975-m6lkrehi 906 1 Results result NNS cord-335975-m6lkrehi 906 2 : : : cord-335975-m6lkrehi 907 1 We -PRON- PRP cord-335975-m6lkrehi 907 2 included include VBD cord-335975-m6lkrehi 907 3 50 50 CD cord-335975-m6lkrehi 907 4 children child NNS cord-335975-m6lkrehi 907 5 with with IN cord-335975-m6lkrehi 907 6 a a DT cord-335975-m6lkrehi 907 7 median median NN cord-335975-m6lkrehi 907 8 ( ( -LRB- cord-335975-m6lkrehi 907 9 range range NN cord-335975-m6lkrehi 907 10 ) ) -RRB- cord-335975-m6lkrehi 907 11 post post JJ cord-335975-m6lkrehi 907 12 natal natal JJ cord-335975-m6lkrehi 907 13 age age NN cord-335975-m6lkrehi 907 14 of of IN cord-335975-m6lkrehi 907 15 27.2 27.2 CD cord-335975-m6lkrehi 908 1 ( ( -LRB- cord-335975-m6lkrehi 908 2 1.1 1.1 CD cord-335975-m6lkrehi 908 3 - - HYPH cord-335975-m6lkrehi 908 4 222.9 222.9 CD cord-335975-m6lkrehi 908 5 ) ) -RRB- cord-335975-m6lkrehi 908 6 months month NNS cord-335975-m6lkrehi 908 7 , , , cord-335975-m6lkrehi 908 8 median median JJ cord-335975-m6lkrehi 908 9 ( ( -LRB- cord-335975-m6lkrehi 908 10 range range NN cord-335975-m6lkrehi 908 11 ) ) -RRB- cord-335975-m6lkrehi 908 12 body body NN cord-335975-m6lkrehi 908 13 weight weight NN cord-335975-m6lkrehi 908 14 of of IN cord-335975-m6lkrehi 908 15 11.9 11.9 CD cord-335975-m6lkrehi 908 16 ( ( -LRB- cord-335975-m6lkrehi 908 17 2.7 2.7 CD cord-335975-m6lkrehi 908 18 - - SYM cord-335975-m6lkrehi 908 19 50 50 CD cord-335975-m6lkrehi 908 20 ) ) -RRB- cord-335975-m6lkrehi 908 21 kg kg NN cord-335975-m6lkrehi 908 22 , , , cord-335975-m6lkrehi 908 23 median median JJ cord-335975-m6lkrehi 908 24 ( ( -LRB- cord-335975-m6lkrehi 908 25 range range NN cord-335975-m6lkrehi 908 26 ) ) -RRB- cord-335975-m6lkrehi 908 27 PELOD-2 PELOD-2 NNP cord-335975-m6lkrehi 908 28 score score NN cord-335975-m6lkrehi 908 29 of of IN cord-335975-m6lkrehi 908 30 4 4 CD cord-335975-m6lkrehi 908 31 ( ( -LRB- cord-335975-m6lkrehi 908 32 0 0 CD cord-335975-m6lkrehi 908 33 - - SYM cord-335975-m6lkrehi 908 34 16 16 CD cord-335975-m6lkrehi 908 35 ) ) -RRB- cord-335975-m6lkrehi 908 36 and and CC cord-335975-m6lkrehi 908 37 median median JJ cord-335975-m6lkrehi 908 38 ( ( -LRB- cord-335975-m6lkrehi 908 39 range range NN cord-335975-m6lkrehi 908 40 ) ) -RRB- cord-335975-m6lkrehi 908 41 estimated estimate VBN cord-335975-m6lkrehi 908 42 creatinine creatinine NN cord-335975-m6lkrehi 908 43 clearance clearance NN cord-335975-m6lkrehi 908 44 of of IN cord-335975-m6lkrehi 908 45 142 142 CD cord-335975-m6lkrehi 908 46 ( ( -LRB- cord-335975-m6lkrehi 908 47 29 29 CD cord-335975-m6lkrehi 908 48 - - SYM cord-335975-m6lkrehi 908 49 675 675 CD cord-335975-m6lkrehi 908 50 ) ) -RRB- cord-335975-m6lkrehi 908 51 mL.min mL.min . cord-335975-m6lkrehi 909 1 -1 -1 JJ cord-335975-m6lkrehi 909 2 .m .m . cord-335975-m6lkrehi 910 1 -2 -2 NNP cord-335975-m6lkrehi 910 2 . . . cord-335975-m6lkrehi 911 1 A a DT cord-335975-m6lkrehi 911 2 one one CD cord-335975-m6lkrehi 911 3 compartment compartment NN cord-335975-m6lkrehi 911 4 model model NN cord-335975-m6lkrehi 911 5 with with IN cord-335975-m6lkrehi 911 6 first first JJ cord-335975-m6lkrehi 911 7 - - HYPH cord-335975-m6lkrehi 911 8 order order NN cord-335975-m6lkrehi 911 9 elimination elimination NN cord-335975-m6lkrehi 911 10 adequately adequately RB cord-335975-m6lkrehi 911 11 described describe VBD cord-335975-m6lkrehi 911 12 the the DT cord-335975-m6lkrehi 911 13 data datum NNS cord-335975-m6lkrehi 911 14 . . . cord-335975-m6lkrehi 912 1 Median median JJ cord-335975-m6lkrehi 912 2 ( ( -LRB- cord-335975-m6lkrehi 912 3 range range NN cord-335975-m6lkrehi 912 4 ) ) -RRB- cord-335975-m6lkrehi 912 5 values value NNS cord-335975-m6lkrehi 912 6 for for IN cord-335975-m6lkrehi 912 7 Piperacillin Piperacillin NNP cord-335975-m6lkrehi 912 8 clearance clearance NN cord-335975-m6lkrehi 912 9 and and CC cord-335975-m6lkrehi 912 10 volume volume NN cord-335975-m6lkrehi 912 11 of of IN cord-335975-m6lkrehi 912 12 distribution distribution NN cord-335975-m6lkrehi 912 13 were be VBD cord-335975-m6lkrehi 912 14 respectively respectively RB cord-335975-m6lkrehi 912 15 3 3 CD cord-335975-m6lkrehi 912 16 ( ( -LRB- cord-335975-m6lkrehi 912 17 0.71 0.71 CD cord-335975-m6lkrehi 912 18 - - SYM cord-335975-m6lkrehi 912 19 10 10 CD cord-335975-m6lkrehi 912 20 ) ) -RRB- cord-335975-m6lkrehi 913 1 L L NNP cord-335975-m6lkrehi 913 2 h h NNP cord-335975-m6lkrehi 913 3 −1 −1 NNP cord-335975-m6lkrehi 913 4 and and CC cord-335975-m6lkrehi 913 5 3.8 3.8 CD cord-335975-m6lkrehi 913 6 ( ( -LRB- cord-335975-m6lkrehi 913 7 0.72 0.72 CD cord-335975-m6lkrehi 913 8 - - SYM cord-335975-m6lkrehi 913 9 25.8 25.8 CD cord-335975-m6lkrehi 913 10 ) ) -RRB- cord-335975-m6lkrehi 914 1 L. L. NNP cord-335975-m6lkrehi 914 2 Body Body NNP cord-335975-m6lkrehi 914 3 weight weight NN cord-335975-m6lkrehi 914 4 ( ( -LRB- cord-335975-m6lkrehi 914 5 allometric allometric JJ cord-335975-m6lkrehi 914 6 relationship relationship NN cord-335975-m6lkrehi 914 7 ) ) -RRB- cord-335975-m6lkrehi 914 8 , , , cord-335975-m6lkrehi 914 9 estimated estimate VBN cord-335975-m6lkrehi 914 10 creatinine creatinine NN cord-335975-m6lkrehi 914 11 clearance clearance NN cord-335975-m6lkrehi 914 12 and and CC cord-335975-m6lkrehi 914 13 PELOD-2 PELOD-2 NNP cord-335975-m6lkrehi 914 14 severity severity NN cord-335975-m6lkrehi 914 15 score score NN cord-335975-m6lkrehi 914 16 were be VBD cord-335975-m6lkrehi 914 17 the the DT cord-335975-m6lkrehi 914 18 covariates covariate NNS cord-335975-m6lkrehi 914 19 explaining explain VBG cord-335975-m6lkrehi 914 20 the the DT cord-335975-m6lkrehi 914 21 estimated estimate VBN cord-335975-m6lkrehi 914 22 between between IN cord-335975-m6lkrehi 914 23 subject subject JJ cord-335975-m6lkrehi 914 24 variability variability NN cord-335975-m6lkrehi 914 25 . . . cord-335975-m6lkrehi 915 1 A a DT cord-335975-m6lkrehi 915 2 third third NN cord-335975-m6lkrehi 915 3 of of IN cord-335975-m6lkrehi 915 4 the the DT cord-335975-m6lkrehi 915 5 cohort cohort NN cord-335975-m6lkrehi 915 6 attained attain VBD cord-335975-m6lkrehi 915 7 the the DT cord-335975-m6lkrehi 915 8 target target NN cord-335975-m6lkrehi 915 9 , , , cord-335975-m6lkrehi 915 10 according accord VBG cord-335975-m6lkrehi 915 11 to to IN cord-335975-m6lkrehi 915 12 our -PRON- PRP$ cord-335975-m6lkrehi 915 13 dosing dose VBG cord-335975-m6lkrehi 915 14 regimen regimen NN cord-335975-m6lkrehi 915 15 and and CC cord-335975-m6lkrehi 915 16 to to IN cord-335975-m6lkrehi 915 17 the the DT cord-335975-m6lkrehi 915 18 European european JJ cord-335975-m6lkrehi 915 19 guidelines guideline NNS cord-335975-m6lkrehi 915 20 . . . cord-335975-m6lkrehi 916 1 To to TO cord-335975-m6lkrehi 916 2 reach reach VB cord-335975-m6lkrehi 916 3 the the DT cord-335975-m6lkrehi 916 4 target target NN cord-335975-m6lkrehi 916 5 and and CC cord-335975-m6lkrehi 916 6 according accord VBG cord-335975-m6lkrehi 916 7 to to IN cord-335975-m6lkrehi 916 8 the the DT cord-335975-m6lkrehi 916 9 simulated simulate VBN cord-335975-m6lkrehi 916 10 dosing dose VBG cord-335975-m6lkrehi 916 11 regimens regimen NNS cord-335975-m6lkrehi 916 12 , , , cord-335975-m6lkrehi 916 13 children child NNS cord-335975-m6lkrehi 916 14 with with IN cord-335975-m6lkrehi 916 15 acute acute JJ cord-335975-m6lkrehi 916 16 kidney kidney NN cord-335975-m6lkrehi 916 17 injury injury NN cord-335975-m6lkrehi 916 18 should should MD cord-335975-m6lkrehi 916 19 receive receive VB cord-335975-m6lkrehi 916 20 intermittent intermittent JJ cord-335975-m6lkrehi 916 21 infusion infusion NN cord-335975-m6lkrehi 916 22 every every DT cord-335975-m6lkrehi 916 23 6 6 CD cord-335975-m6lkrehi 916 24 h h NN cord-335975-m6lkrehi 916 25 , , , cord-335975-m6lkrehi 916 26 administered administer VBN cord-335975-m6lkrehi 916 27 on on IN cord-335975-m6lkrehi 916 28 30 30 CD cord-335975-m6lkrehi 916 29 min min NN cord-335975-m6lkrehi 916 30 . . . cord-335975-m6lkrehi 917 1 Those those DT cord-335975-m6lkrehi 917 2 with with IN cord-335975-m6lkrehi 917 3 augmented augmented JJ cord-335975-m6lkrehi 917 4 renal renal JJ cord-335975-m6lkrehi 917 5 clearance clearance NN cord-335975-m6lkrehi 917 6 should should MD cord-335975-m6lkrehi 917 7 receive receive VB cord-335975-m6lkrehi 917 8 a a DT cord-335975-m6lkrehi 917 9 continuous continuous JJ cord-335975-m6lkrehi 917 10 infusion infusion NN cord-335975-m6lkrehi 917 11 . . . cord-335975-m6lkrehi 918 1 To to TO cord-335975-m6lkrehi 918 2 reach reach VB cord-335975-m6lkrehi 918 3 the the DT cord-335975-m6lkrehi 918 4 target target NN cord-335975-m6lkrehi 918 5 , , , cord-335975-m6lkrehi 918 6 standard standard JJ cord-335975-m6lkrehi 918 7 intermittent intermittent JJ cord-335975-m6lkrehi 918 8 Piperacillin Piperacillin NNP cord-335975-m6lkrehi 918 9 dosing dose VBG cord-335975-m6lkrehi 918 10 regimen regimen NN cord-335975-m6lkrehi 918 11 in in IN cord-335975-m6lkrehi 918 12 critically critically RB cord-335975-m6lkrehi 918 13 ill ill JJ cord-335975-m6lkrehi 918 14 children child NNS cord-335975-m6lkrehi 918 15 is be VBZ cord-335975-m6lkrehi 918 16 not not RB cord-335975-m6lkrehi 918 17 appropriate appropriate JJ cord-335975-m6lkrehi 918 18 . . . cord-335975-m6lkrehi 919 1 In in IN cord-335975-m6lkrehi 919 2 addition addition NN cord-335975-m6lkrehi 919 3 to to IN cord-335975-m6lkrehi 919 4 body body NN cord-335975-m6lkrehi 919 5 weight weight NN cord-335975-m6lkrehi 919 6 , , , cord-335975-m6lkrehi 919 7 dosing dose VBG cord-335975-m6lkrehi 919 8 regimens regimen NNS cord-335975-m6lkrehi 919 9 should should MD cord-335975-m6lkrehi 919 10 take take VB cord-335975-m6lkrehi 919 11 into into IN cord-335975-m6lkrehi 919 12 account account NN cord-335975-m6lkrehi 919 13 the the DT cord-335975-m6lkrehi 919 14 creatinine creatinine NN cord-335975-m6lkrehi 919 15 clearance clearance NN cord-335975-m6lkrehi 919 16 . . . cord-335975-m6lkrehi 920 1 Continuous continuous JJ cord-335975-m6lkrehi 920 2 infusion infusion NN cord-335975-m6lkrehi 920 3 is be VBZ cord-335975-m6lkrehi 920 4 adequate adequate JJ cord-335975-m6lkrehi 920 5 for for IN cord-335975-m6lkrehi 920 6 children child NNS cord-335975-m6lkrehi 920 7 with with IN cord-335975-m6lkrehi 920 8 augmented augment VBN cord-335975-m6lkrehi 920 9 renal renal JJ cord-335975-m6lkrehi 920 10 clearance clearance NN cord-335975-m6lkrehi 920 11 . . . cord-335975-m6lkrehi 921 1 Piperacillin Piperacillin NNP cord-335975-m6lkrehi 921 2 individualized individualize VBN cord-335975-m6lkrehi 921 3 dosing dose VBG cord-335975-m6lkrehi 921 4 regimens regimen NNS cord-335975-m6lkrehi 921 5 and and CC cord-335975-m6lkrehi 921 6 therapeutic therapeutic JJ cord-335975-m6lkrehi 921 7 drug drug NN cord-335975-m6lkrehi 921 8 monitoring monitoring NN cord-335975-m6lkrehi 921 9 are be VBP cord-335975-m6lkrehi 921 10 mandatory mandatory JJ cord-335975-m6lkrehi 921 11 in in IN cord-335975-m6lkrehi 921 12 pediatric pediatric JJ cord-335975-m6lkrehi 921 13 intensive intensive JJ cord-335975-m6lkrehi 921 14 care care NN cord-335975-m6lkrehi 921 15 unit unit NN cord-335975-m6lkrehi 921 16 . . . cord-335975-m6lkrehi 922 1 Introduction introduction NN cord-335975-m6lkrehi 922 2 : : : cord-335975-m6lkrehi 923 1 All all DT cord-335975-m6lkrehi 923 2 data datum NNS cord-335975-m6lkrehi 923 3 support support VBP cord-335975-m6lkrehi 923 4 the the DT cord-335975-m6lkrehi 923 5 need need NN cord-335975-m6lkrehi 923 6 for for IN cord-335975-m6lkrehi 923 7 early early JJ cord-335975-m6lkrehi 923 8 recognition recognition NN cord-335975-m6lkrehi 923 9 , , , cord-335975-m6lkrehi 923 10 evaluation evaluation NN cord-335975-m6lkrehi 923 11 of of IN cord-335975-m6lkrehi 923 12 pain pain NN cord-335975-m6lkrehi 923 13 in in IN cord-335975-m6lkrehi 923 14 the the DT cord-335975-m6lkrehi 923 15 NICU NICU NNP cord-335975-m6lkrehi 923 16 . . . cord-335975-m6lkrehi 924 1 Multiparametric multiparametric JJ cord-335975-m6lkrehi 924 2 analysis analysis NN cord-335975-m6lkrehi 924 3 including include VBG cord-335975-m6lkrehi 924 4 physiological physiological JJ cord-335975-m6lkrehi 924 5 parameters parameter NNS cord-335975-m6lkrehi 924 6 could could MD cord-335975-m6lkrehi 924 7 be be VB cord-335975-m6lkrehi 924 8 useful useful JJ cord-335975-m6lkrehi 924 9 to to TO cord-335975-m6lkrehi 924 10 have have VB cord-335975-m6lkrehi 924 11 a a DT cord-335975-m6lkrehi 924 12 more more RBR cord-335975-m6lkrehi 924 13 objective objective JJ cord-335975-m6lkrehi 924 14 evaluation evaluation NN cord-335975-m6lkrehi 924 15 of of IN cord-335975-m6lkrehi 924 16 pain pain NN cord-335975-m6lkrehi 924 17 in in IN cord-335975-m6lkrehi 924 18 the the DT cord-335975-m6lkrehi 924 19 NICU NICU NNP cord-335975-m6lkrehi 924 20 compared compare VBN cord-335975-m6lkrehi 924 21 to to IN cord-335975-m6lkrehi 924 22 scales scale NNS cord-335975-m6lkrehi 924 23 built build VBN cord-335975-m6lkrehi 924 24 on on IN cord-335975-m6lkrehi 924 25 external external JJ cord-335975-m6lkrehi 924 26 - - HYPH cord-335975-m6lkrehi 924 27 evaluation evaluation NN cord-335975-m6lkrehi 924 28 . . . cord-335975-m6lkrehi 925 1 The the DT cord-335975-m6lkrehi 925 2 Newborn Newborn NNP cord-335975-m6lkrehi 925 3 Infant Infant NNP cord-335975-m6lkrehi 925 4 Parasympathetic parasympathetic JJ cord-335975-m6lkrehi 925 5 Evaluation Evaluation NNP cord-335975-m6lkrehi 925 6 ( ( -LRB- cord-335975-m6lkrehi 925 7 NIPE NIPE NNP cord-335975-m6lkrehi 925 8 ® ® '' cord-335975-m6lkrehi 925 9 ) ) -RRB- cord-335975-m6lkrehi 925 10 was be VBD cord-335975-m6lkrehi 925 11 developed develop VBN cord-335975-m6lkrehi 925 12 to to TO cord-335975-m6lkrehi 925 13 assess assess VB cord-335975-m6lkrehi 925 14 pain pain NN cord-335975-m6lkrehi 925 15 in in IN cord-335975-m6lkrehi 925 16 newborns newborn NNS cord-335975-m6lkrehi 925 17 and and CC cord-335975-m6lkrehi 925 18 infant infant NN cord-335975-m6lkrehi 925 19 , , , cord-335975-m6lkrehi 925 20 from from IN cord-335975-m6lkrehi 925 21 preterm preterm NNS cord-335975-m6lkrehi 925 22 to to IN cord-335975-m6lkrehi 925 23 the the DT cord-335975-m6lkrehi 925 24 age age NN cord-335975-m6lkrehi 925 25 of of IN cord-335975-m6lkrehi 925 26 2 2 CD cord-335975-m6lkrehi 925 27 years year NNS cord-335975-m6lkrehi 925 28 . . . cord-335975-m6lkrehi 926 1 Patients patient NNS cord-335975-m6lkrehi 926 2 and and CC cord-335975-m6lkrehi 926 3 methods method NNS cord-335975-m6lkrehi 926 4 : : : cord-335975-m6lkrehi 926 5 We -PRON- PRP cord-335975-m6lkrehi 926 6 conducted conduct VBD cord-335975-m6lkrehi 926 7 a a DT cord-335975-m6lkrehi 926 8 monocentric monocentric JJ cord-335975-m6lkrehi 926 9 , , , cord-335975-m6lkrehi 926 10 prospective prospective JJ cord-335975-m6lkrehi 926 11 study study NN cord-335975-m6lkrehi 926 12 to to TO cord-335975-m6lkrehi 926 13 compare compare VB cord-335975-m6lkrehi 926 14 the the DT cord-335975-m6lkrehi 926 15 instantaneous instantaneous JJ cord-335975-m6lkrehi 926 16 NIPE NIPE NNP cord-335975-m6lkrehi 926 17 ® ® POS cord-335975-m6lkrehi 926 18 index index NN cord-335975-m6lkrehi 926 19 value value NN cord-335975-m6lkrehi 926 20 ( ( -LRB- cord-335975-m6lkrehi 926 21 NIPEi NIPEi NNP cord-335975-m6lkrehi 926 22 ® ® VBG cord-335975-m6lkrehi 926 23 ) ) -RRB- cord-335975-m6lkrehi 926 24 to to IN cord-335975-m6lkrehi 926 25 the the DT cord-335975-m6lkrehi 926 26 DAN DAN NNP cord-335975-m6lkrehi 926 27 scale scale NN cord-335975-m6lkrehi 926 28 during during IN cord-335975-m6lkrehi 926 29 acute acute JJ cord-335975-m6lkrehi 926 30 procedural procedural JJ cord-335975-m6lkrehi 926 31 pain pain NN cord-335975-m6lkrehi 926 32 ( ( -LRB- cord-335975-m6lkrehi 926 33 PICC PICC NNP cord-335975-m6lkrehi 926 34 line line NN cord-335975-m6lkrehi 926 35 insertion insertion NN cord-335975-m6lkrehi 926 36 ) ) -RRB- cord-335975-m6lkrehi 926 37 in in IN cord-335975-m6lkrehi 926 38 preterm preterm JJ cord-335975-m6lkrehi 926 39 infants infant NNS cord-335975-m6lkrehi 926 40 ( ( -LRB- cord-335975-m6lkrehi 926 41 under under IN cord-335975-m6lkrehi 926 42 37 37 CD cord-335975-m6lkrehi 926 43 GW GW NNP cord-335975-m6lkrehi 926 44 ) ) -RRB- cord-335975-m6lkrehi 926 45 . . . cord-335975-m6lkrehi 927 1 The the DT cord-335975-m6lkrehi 927 2 operators operator NNS cord-335975-m6lkrehi 927 3 and and CC cord-335975-m6lkrehi 927 4 the the DT cord-335975-m6lkrehi 927 5 nurse nurse NN cord-335975-m6lkrehi 927 6 were be VBD cord-335975-m6lkrehi 927 7 blinded blind VBN cord-335975-m6lkrehi 927 8 to to IN cord-335975-m6lkrehi 927 9 the the DT cord-335975-m6lkrehi 927 10 continuous continuous JJ cord-335975-m6lkrehi 927 11 recording recording NN cord-335975-m6lkrehi 927 12 of of IN cord-335975-m6lkrehi 927 13 NIPEi NIPEi NNPS cord-335975-m6lkrehi 928 1 ® ® VB cord-335975-m6lkrehi 928 2 during during IN cord-335975-m6lkrehi 928 3 the the DT cord-335975-m6lkrehi 928 4 entire entire JJ cord-335975-m6lkrehi 928 5 procedure procedure NN cord-335975-m6lkrehi 928 6 . . . cord-335975-m6lkrehi 929 1 DAN DAN NNP cord-335975-m6lkrehi 929 2 scale scale NN cord-335975-m6lkrehi 929 3 was be VBD cord-335975-m6lkrehi 929 4 assessed assess VBN cord-335975-m6lkrehi 929 5 every every DT cord-335975-m6lkrehi 929 6 5 5 CD cord-335975-m6lkrehi 929 7 min min NN cord-335975-m6lkrehi 929 8 by by IN cord-335975-m6lkrehi 929 9 a a DT cord-335975-m6lkrehi 929 10 third third JJ cord-335975-m6lkrehi 929 11 person person NN cord-335975-m6lkrehi 929 12 , , , cord-335975-m6lkrehi 929 13 trained train VBN cord-335975-m6lkrehi 929 14 to to IN cord-335975-m6lkrehi 929 15 this this DT cord-335975-m6lkrehi 929 16 scale scale NN cord-335975-m6lkrehi 929 17 and and CC cord-335975-m6lkrehi 929 18 blinded blind VBD cord-335975-m6lkrehi 929 19 to to IN cord-335975-m6lkrehi 930 1 NIPEi NIPEi NNP cord-335975-m6lkrehi 930 2 ® ® VBP cord-335975-m6lkrehi 930 3 . . . cord-335975-m6lkrehi 931 1 A a DT cord-335975-m6lkrehi 931 2 direct direct JJ cord-335975-m6lkrehi 931 3 correlation correlation NN cord-335975-m6lkrehi 931 4 assessment assessment NN cord-335975-m6lkrehi 931 5 between between IN cord-335975-m6lkrehi 931 6 the the DT cord-335975-m6lkrehi 931 7 DAN DAN NNP cord-335975-m6lkrehi 931 8 scale scale NN cord-335975-m6lkrehi 931 9 and and CC cord-335975-m6lkrehi 931 10 the the DT cord-335975-m6lkrehi 931 11 NIPEi NIPEi NNPS cord-335975-m6lkrehi 931 12 ® ® NN cord-335975-m6lkrehi 931 13 was be VBD cord-335975-m6lkrehi 931 14 performed perform VBN cord-335975-m6lkrehi 931 15 by by IN cord-335975-m6lkrehi 931 16 calculating calculate VBG cord-335975-m6lkrehi 931 17 the the DT cord-335975-m6lkrehi 931 18 Pearson Pearson NNP cord-335975-m6lkrehi 931 19 's 's POS cord-335975-m6lkrehi 931 20 linear linear JJ cord-335975-m6lkrehi 931 21 correlation correlation NN cord-335975-m6lkrehi 931 22 coefficient coefficient NN cord-335975-m6lkrehi 931 23 . . . cord-335975-m6lkrehi 932 1 The the DT cord-335975-m6lkrehi 932 2 differences difference NNS cord-335975-m6lkrehi 932 3 between between IN cord-335975-m6lkrehi 932 4 the the DT cord-335975-m6lkrehi 932 5 NIPEi NIPEi NNPS cord-335975-m6lkrehi 932 6 ® ® NN cord-335975-m6lkrehi 932 7 of of IN cord-335975-m6lkrehi 932 8 non non JJ cord-335975-m6lkrehi 932 9 - - JJ cord-335975-m6lkrehi 932 10 painful painful JJ cord-335975-m6lkrehi 932 11 ( ( -LRB- cord-335975-m6lkrehi 932 12 DAN DAN NNP cord-335975-m6lkrehi 932 13 < < XX cord-335975-m6lkrehi 932 14 3 3 CD cord-335975-m6lkrehi 932 15 ) ) -RRB- cord-335975-m6lkrehi 932 16 and and CC cord-335975-m6lkrehi 932 17 painful painful JJ cord-335975-m6lkrehi 932 18 ( ( -LRB- cord-335975-m6lkrehi 932 19 DAN DAN NNP cord-335975-m6lkrehi 932 20 ≥ ≥ NNP cord-335975-m6lkrehi 932 21 3 3 CD cord-335975-m6lkrehi 932 22 ) ) -RRB- cord-335975-m6lkrehi 932 23 infants infant NNS cord-335975-m6lkrehi 932 24 were be VBD cord-335975-m6lkrehi 932 25 estimated estimate VBN cord-335975-m6lkrehi 932 26 by by IN cord-335975-m6lkrehi 932 27 the the DT cord-335975-m6lkrehi 932 28 Wilcoxon Wilcoxon NNP cord-335975-m6lkrehi 932 29 - - HYPH cord-335975-m6lkrehi 932 30 Mann Mann NNP cord-335975-m6lkrehi 932 31 - - HYPH cord-335975-m6lkrehi 932 32 Whitney Whitney NNP cord-335975-m6lkrehi 932 33 test test NN cord-335975-m6lkrehi 932 34 . . . cord-335975-m6lkrehi 933 1 The the DT cord-335975-m6lkrehi 933 2 usefulness usefulness NN cord-335975-m6lkrehi 933 3 of of IN cord-335975-m6lkrehi 933 4 NIPEi NIPEi NNPS cord-335975-m6lkrehi 933 5 ® ® VBP cord-335975-m6lkrehi 933 6 as as IN cord-335975-m6lkrehi 933 7 a a DT cord-335975-m6lkrehi 933 8 new new JJ cord-335975-m6lkrehi 933 9 tool tool NN cord-335975-m6lkrehi 933 10 for for IN cord-335975-m6lkrehi 933 11 pain pain NN cord-335975-m6lkrehi 933 12 assessment assessment NN cord-335975-m6lkrehi 933 13 in in IN cord-335975-m6lkrehi 933 14 neonates neonate NNS cord-335975-m6lkrehi 933 15 was be VBD cord-335975-m6lkrehi 933 16 estimated estimate VBN cord-335975-m6lkrehi 933 17 by by IN cord-335975-m6lkrehi 933 18 the the DT cord-335975-m6lkrehi 933 19 corresponding corresponding JJ cord-335975-m6lkrehi 933 20 ROC ROC NNP cord-335975-m6lkrehi 933 21 curve curve NN cord-335975-m6lkrehi 933 22 . . . cord-335975-m6lkrehi 934 1 Our -PRON- PRP$ cord-335975-m6lkrehi 934 2 study study NN cord-335975-m6lkrehi 934 3 was be VBD cord-335975-m6lkrehi 934 4 approved approve VBN cord-335975-m6lkrehi 934 5 by by IN cord-335975-m6lkrehi 934 6 our -PRON- PRP$ cord-335975-m6lkrehi 934 7 local local JJ cord-335975-m6lkrehi 934 8 ethic ethic NN cord-335975-m6lkrehi 934 9 institutional institutional JJ cord-335975-m6lkrehi 934 10 review review NNP cord-335975-m6lkrehi 934 11 board board NNP cord-335975-m6lkrehi 934 12 . . . cord-335975-m6lkrehi 935 1 Results result NNS cord-335975-m6lkrehi 935 2 : : : cord-335975-m6lkrehi 936 1 Thirty thirty CD cord-335975-m6lkrehi 936 2 - - HYPH cord-335975-m6lkrehi 936 3 five five CD cord-335975-m6lkrehi 936 4 preterm preterm JJ cord-335975-m6lkrehi 936 5 infants infant NNS cord-335975-m6lkrehi 936 6 were be VBD cord-335975-m6lkrehi 936 7 included include VBN cord-335975-m6lkrehi 936 8 , , , cord-335975-m6lkrehi 936 9 NIPEi NIPEi NNP cord-335975-m6lkrehi 936 10 ® ® POS cord-335975-m6lkrehi 936 11 data datum NNS cord-335975-m6lkrehi 936 12 were be VBD cord-335975-m6lkrehi 936 13 incomplete incomplete JJ cord-335975-m6lkrehi 936 14 in in IN cord-335975-m6lkrehi 936 15 3 3 CD cord-335975-m6lkrehi 936 16 infants infant NNS cord-335975-m6lkrehi 936 17 . . . cord-335975-m6lkrehi 937 1 Fifty fifty CD cord-335975-m6lkrehi 937 2 percent percent NN cord-335975-m6lkrehi 937 3 of of IN cord-335975-m6lkrehi 937 4 newborns newborn NNS cord-335975-m6lkrehi 937 5 were be VBD cord-335975-m6lkrehi 937 6 born bear VBN cord-335975-m6lkrehi 937 7 before before IN cord-335975-m6lkrehi 937 8 31 31 CD cord-335975-m6lkrehi 937 9 GW GW NNP cord-335975-m6lkrehi 937 10 , , , cord-335975-m6lkrehi 937 11 and and CC cord-335975-m6lkrehi 937 12 66 66 CD cord-335975-m6lkrehi 937 13 % % NN cord-335975-m6lkrehi 937 14 had have VBD cord-335975-m6lkrehi 937 15 non non JJ cord-335975-m6lkrehi 937 16 - - JJ cord-335975-m6lkrehi 937 17 invasive invasive JJ cord-335975-m6lkrehi 937 18 respiratory respiratory JJ cord-335975-m6lkrehi 937 19 support support NN cord-335975-m6lkrehi 937 20 ( ( -LRB- cord-335975-m6lkrehi 937 21 continuous continuous JJ cord-335975-m6lkrehi 937 22 positive positive JJ cord-335975-m6lkrehi 937 23 airway airway NN cord-335975-m6lkrehi 937 24 pressure pressure NN cord-335975-m6lkrehi 937 25 CPAP CPAP NNP cord-335975-m6lkrehi 937 26 ) ) -RRB- cord-335975-m6lkrehi 937 27 . . . cord-335975-m6lkrehi 938 1 At at IN cord-335975-m6lkrehi 938 2 the the DT cord-335975-m6lkrehi 938 3 time time NN cord-335975-m6lkrehi 938 4 of of IN cord-335975-m6lkrehi 938 5 the the DT cord-335975-m6lkrehi 938 6 procedure procedure NN cord-335975-m6lkrehi 938 7 , , , cord-335975-m6lkrehi 938 8 newborns newborn NNS cord-335975-m6lkrehi 938 9 had have VBD cord-335975-m6lkrehi 938 10 a a DT cord-335975-m6lkrehi 938 11 median median JJ cord-335975-m6lkrehi 938 12 post post JJ cord-335975-m6lkrehi 938 13 - - JJ cord-335975-m6lkrehi 938 14 natal natal JJ cord-335975-m6lkrehi 938 15 age age NN cord-335975-m6lkrehi 938 16 of of IN cord-335975-m6lkrehi 938 17 3 3 CD cord-335975-m6lkrehi 938 18 days day NNS cord-335975-m6lkrehi 938 19 and and CC cord-335975-m6lkrehi 938 20 a a DT cord-335975-m6lkrehi 938 21 median median JJ cord-335975-m6lkrehi 938 22 weight weight NN cord-335975-m6lkrehi 938 23 of of IN cord-335975-m6lkrehi 938 24 1180 1180 CD cord-335975-m6lkrehi 938 25 grams gram NNS cord-335975-m6lkrehi 938 26 . . . cord-335975-m6lkrehi 939 1 There there EX cord-335975-m6lkrehi 939 2 was be VBD cord-335975-m6lkrehi 939 3 a a DT cord-335975-m6lkrehi 939 4 moderate moderate JJ cord-335975-m6lkrehi 939 5 correlation correlation NN cord-335975-m6lkrehi 939 6 between between IN cord-335975-m6lkrehi 939 7 the the DT cord-335975-m6lkrehi 939 8 NIPEi NIPEi NNPS cord-335975-m6lkrehi 939 9 ® ® NN cord-335975-m6lkrehi 939 10 index index NN cord-335975-m6lkrehi 939 11 and and CC cord-335975-m6lkrehi 939 12 the the DT cord-335975-m6lkrehi 939 13 DAN DAN NNP cord-335975-m6lkrehi 939 14 scores score NNS cord-335975-m6lkrehi 939 15 ( ( -LRB- cord-335975-m6lkrehi 939 16 r r NN cord-335975-m6lkrehi 939 17 = = NN cord-335975-m6lkrehi 939 18 0.605 0.605 CD cord-335975-m6lkrehi 940 1 + + CC cord-335975-m6lkrehi 940 2 p p NN cord-335975-m6lkrehi 940 3 < < XX cord-335975-m6lkrehi 940 4 0.001 0.001 CD cord-335975-m6lkrehi 940 5 ) ) -RRB- cord-335975-m6lkrehi 940 6 . . . cord-335975-m6lkrehi 941 1 The the DT cord-335975-m6lkrehi 941 2 median median JJ cord-335975-m6lkrehi 941 3 NIPEi NIPEi NNS cord-335975-m6lkrehi 941 4 ® ® VBP cord-335975-m6lkrehi 941 5 index index NN cord-335975-m6lkrehi 941 6 was be VBD cord-335975-m6lkrehi 941 7 59 59 CD cord-335975-m6lkrehi 941 8 for for IN cord-335975-m6lkrehi 941 9 non non JJ cord-335975-m6lkrehi 941 10 - - JJ cord-335975-m6lkrehi 941 11 painful painful JJ cord-335975-m6lkrehi 941 12 events event NNS cord-335975-m6lkrehi 941 13 vs. vs. IN cord-335975-m6lkrehi 941 14 43 43 CD cord-335975-m6lkrehi 941 15 for for IN cord-335975-m6lkrehi 941 16 painful painful JJ cord-335975-m6lkrehi 941 17 events event NNS cord-335975-m6lkrehi 941 18 , , , cord-335975-m6lkrehi 941 19 p p NN cord-335975-m6lkrehi 941 20 < < XX cord-335975-m6lkrehi 941 21 0.001 0.001 CD cord-335975-m6lkrehi 941 22 . . . cord-335975-m6lkrehi 942 1 The the DT cord-335975-m6lkrehi 942 2 area area NN cord-335975-m6lkrehi 942 3 under under IN cord-335975-m6lkrehi 942 4 the the DT cord-335975-m6lkrehi 942 5 ROC ROC NNP cord-335975-m6lkrehi 942 6 curve curve NN cord-335975-m6lkrehi 942 7 was be VBD cord-335975-m6lkrehi 942 8 0.92 0.92 CD cord-335975-m6lkrehi 942 9 . . . cord-335975-m6lkrehi 943 1 For for IN cord-335975-m6lkrehi 943 2 a a DT cord-335975-m6lkrehi 943 3 threshold threshold NN cord-335975-m6lkrehi 943 4 of of IN cord-335975-m6lkrehi 943 5 NIPEi NIPEi NNPS cord-335975-m6lkrehi 943 6 ® ® POS cord-335975-m6lkrehi 943 7 < < XX cord-335975-m6lkrehi 943 8 50 50 CD cord-335975-m6lkrehi 943 9 , , , cord-335975-m6lkrehi 943 10 the the DT cord-335975-m6lkrehi 943 11 sensitivity sensitivity NN cord-335975-m6lkrehi 943 12 was be VBD cord-335975-m6lkrehi 943 13 91.3 91.3 CD cord-335975-m6lkrehi 943 14 % % NN cord-335975-m6lkrehi 943 15 , , , cord-335975-m6lkrehi 943 16 the the DT cord-335975-m6lkrehi 943 17 specificity specificity NN cord-335975-m6lkrehi 943 18 was be VBD cord-335975-m6lkrehi 943 19 83 83 CD cord-335975-m6lkrehi 943 20 % % NN cord-335975-m6lkrehi 943 21 . . . cord-335975-m6lkrehi 944 1 Positive positive JJ cord-335975-m6lkrehi 944 2 likelihood likelihood NN cord-335975-m6lkrehi 944 3 ratio ratio NN cord-335975-m6lkrehi 944 4 was be VBD cord-335975-m6lkrehi 944 5 5.36 5.36 CD cord-335975-m6lkrehi 944 6 and and CC cord-335975-m6lkrehi 944 7 the the DT cord-335975-m6lkrehi 944 8 negative negative JJ cord-335975-m6lkrehi 944 9 likelihood likelihood NN cord-335975-m6lkrehi 944 10 ratio ratio NN cord-335975-m6lkrehi 944 11 was be VBD cord-335975-m6lkrehi 944 12 0.10 0.10 CD cord-335975-m6lkrehi 945 1 ( ( -LRB- cord-335975-m6lkrehi 945 2 Fig Fig NNP cord-335975-m6lkrehi 945 3 . . NNP cord-335975-m6lkrehi 945 4 1 1 CD cord-335975-m6lkrehi 945 5 ) ) -RRB- cord-335975-m6lkrehi 945 6 . . . cord-335975-m6lkrehi 946 1 We -PRON- PRP cord-335975-m6lkrehi 946 2 showed show VBD cord-335975-m6lkrehi 946 3 a a DT cord-335975-m6lkrehi 946 4 correlation correlation NN cord-335975-m6lkrehi 946 5 between between IN cord-335975-m6lkrehi 946 6 the the DT cord-335975-m6lkrehi 946 7 DAN DAN NNP cord-335975-m6lkrehi 946 8 scale scale NN cord-335975-m6lkrehi 946 9 and and CC cord-335975-m6lkrehi 946 10 the the DT cord-335975-m6lkrehi 946 11 NIPEi NIPEi NNPS cord-335975-m6lkrehi 946 12 ® ® POS cord-335975-m6lkrehi 946 13 index index NN cord-335975-m6lkrehi 946 14 for for IN cord-335975-m6lkrehi 946 15 pain pain NN cord-335975-m6lkrehi 946 16 assessment assessment NN cord-335975-m6lkrehi 946 17 in in IN cord-335975-m6lkrehi 946 18 preterm preterm JJ cord-335975-m6lkrehi 946 19 infants infant NNS cord-335975-m6lkrehi 946 20 . . . cord-335975-m6lkrehi 947 1 The the DT cord-335975-m6lkrehi 947 2 NIPE NIPE NNP cord-335975-m6lkrehi 947 3 ® ® NN cord-335975-m6lkrehi 947 4 monitor monitor NN cord-335975-m6lkrehi 947 5 could could MD cord-335975-m6lkrehi 947 6 be be VB cord-335975-m6lkrehi 947 7 a a DT cord-335975-m6lkrehi 947 8 useful useful JJ cord-335975-m6lkrehi 947 9 and and CC cord-335975-m6lkrehi 947 10 non non JJ cord-335975-m6lkrehi 947 11 - - JJ cord-335975-m6lkrehi 947 12 invasive invasive JJ cord-335975-m6lkrehi 947 13 tool tool NN cord-335975-m6lkrehi 947 14 for for IN cord-335975-m6lkrehi 947 15 pain pain NN cord-335975-m6lkrehi 947 16 assessment assessment NN cord-335975-m6lkrehi 947 17 in in IN cord-335975-m6lkrehi 947 18 neonates neonate NNS cord-335975-m6lkrehi 947 19 . . . cord-335975-m6lkrehi 948 1 Further further JJ cord-335975-m6lkrehi 948 2 studies study NNS cord-335975-m6lkrehi 948 3 are be VBP cord-335975-m6lkrehi 948 4 needed need VBN cord-335975-m6lkrehi 948 5 to to TO cord-335975-m6lkrehi 948 6 confirm confirm VB cord-335975-m6lkrehi 948 7 our -PRON- PRP$ cord-335975-m6lkrehi 948 8 results result NNS cord-335975-m6lkrehi 948 9 and and CC cord-335975-m6lkrehi 948 10 to to TO cord-335975-m6lkrehi 948 11 define define VB cord-335975-m6lkrehi 948 12 more more RBR cord-335975-m6lkrehi 948 13 precisely precisely RB cord-335975-m6lkrehi 948 14 the the DT cord-335975-m6lkrehi 948 15 place place NN cord-335975-m6lkrehi 948 16 of of IN cord-335975-m6lkrehi 948 17 such such JJ cord-335975-m6lkrehi 948 18 monitors monitor NNS cord-335975-m6lkrehi 948 19 for for IN cord-335975-m6lkrehi 948 20 pain pain NN cord-335975-m6lkrehi 948 21 evaluation evaluation NN cord-335975-m6lkrehi 948 22 in in IN cord-335975-m6lkrehi 948 23 daily daily JJ cord-335975-m6lkrehi 948 24 clinical clinical JJ cord-335975-m6lkrehi 948 25 practice practice NN cord-335975-m6lkrehi 948 26 in in IN cord-335975-m6lkrehi 948 27 the the DT cord-335975-m6lkrehi 948 28 NICU NICU NNP cord-335975-m6lkrehi 948 29 . . . cord-335975-m6lkrehi 949 1 Introduction introduction NN cord-335975-m6lkrehi 949 2 : : : cord-335975-m6lkrehi 950 1 The the DT cord-335975-m6lkrehi 950 2 aim aim NN cord-335975-m6lkrehi 950 3 was be VBD cord-335975-m6lkrehi 950 4 to to TO cord-335975-m6lkrehi 950 5 identify identify VB cord-335975-m6lkrehi 950 6 factors factor NNS cord-335975-m6lkrehi 950 7 associated associate VBN cord-335975-m6lkrehi 950 8 with with IN cord-335975-m6lkrehi 950 9 the the DT cord-335975-m6lkrehi 950 10 occurrence occurrence NN cord-335975-m6lkrehi 950 11 of of IN cord-335975-m6lkrehi 950 12 acute acute JJ cord-335975-m6lkrehi 950 13 pituitary pituitary JJ cord-335975-m6lkrehi 950 14 hormone hormone NN cord-335975-m6lkrehi 950 15 dysfunction dysfunction NN cord-335975-m6lkrehi 950 16 in in IN cord-335975-m6lkrehi 950 17 children child NNS cord-335975-m6lkrehi 950 18 with with IN cord-335975-m6lkrehi 950 19 moderate moderate JJ cord-335975-m6lkrehi 950 20 to to IN cord-335975-m6lkrehi 950 21 severe severe JJ cord-335975-m6lkrehi 950 22 TBI TBI NNP cord-335975-m6lkrehi 950 23 and and CC cord-335975-m6lkrehi 950 24 to to TO cord-335975-m6lkrehi 950 25 describe describe VB cord-335975-m6lkrehi 950 26 the the DT cord-335975-m6lkrehi 950 27 impact impact NN cord-335975-m6lkrehi 950 28 of of IN cord-335975-m6lkrehi 950 29 this this DT cord-335975-m6lkrehi 950 30 dysfunction dysfunction NN cord-335975-m6lkrehi 950 31 on on IN cord-335975-m6lkrehi 950 32 the the DT cord-335975-m6lkrehi 950 33 stability stability NN cord-335975-m6lkrehi 950 34 of of IN cord-335975-m6lkrehi 950 35 the the DT cord-335975-m6lkrehi 950 36 children child NNS cord-335975-m6lkrehi 950 37 . . . cord-335975-m6lkrehi 951 1 Patients patient NNS cord-335975-m6lkrehi 951 2 and and CC cord-335975-m6lkrehi 951 3 methods method NNS cord-335975-m6lkrehi 951 4 : : : cord-335975-m6lkrehi 951 5 Prospective prospective JJ cord-335975-m6lkrehi 951 6 bicenter bicenter NN cord-335975-m6lkrehi 951 7 study study NN cord-335975-m6lkrehi 951 8 including include VBG cord-335975-m6lkrehi 951 9 all all DT cord-335975-m6lkrehi 951 10 children child NNS cord-335975-m6lkrehi 951 11 aged age VBN cord-335975-m6lkrehi 951 12 between between IN cord-335975-m6lkrehi 951 13 1 1 CD cord-335975-m6lkrehi 951 14 month month NN cord-335975-m6lkrehi 951 15 to to IN cord-335975-m6lkrehi 951 16 17 17 CD cord-335975-m6lkrehi 951 17 years year NNS cord-335975-m6lkrehi 951 18 , , , cord-335975-m6lkrehi 951 19 admitted admit VBN cord-335975-m6lkrehi 951 20 to to IN cord-335975-m6lkrehi 951 21 PICU PICU NNP cord-335975-m6lkrehi 951 22 for for IN cord-335975-m6lkrehi 951 23 a a DT cord-335975-m6lkrehi 951 24 moderate moderate JJ cord-335975-m6lkrehi 951 25 - - HYPH cord-335975-m6lkrehi 951 26 severe severe JJ cord-335975-m6lkrehi 951 27 TBI tbi NN cord-335975-m6lkrehi 951 28 and and CC cord-335975-m6lkrehi 951 29 with with IN cord-335975-m6lkrehi 951 30 an an DT cord-335975-m6lkrehi 951 31 expected expect VBN cord-335975-m6lkrehi 951 32 stay stay NN cord-335975-m6lkrehi 951 33 > > XX cord-335975-m6lkrehi 951 34 2 2 CD cord-335975-m6lkrehi 951 35 days day NNS cord-335975-m6lkrehi 951 36 . . . cord-335975-m6lkrehi 952 1 Setting set VBG cord-335975-m6lkrehi 952 2 - - HYPH cord-335975-m6lkrehi 952 3 Pediatric pediatric JJ cord-335975-m6lkrehi 952 4 intensive intensive JJ cord-335975-m6lkrehi 952 5 care care NN cord-335975-m6lkrehi 952 6 units unit NNS cord-335975-m6lkrehi 952 7 of of IN cord-335975-m6lkrehi 952 8 Grenoble Grenoble NNP cord-335975-m6lkrehi 952 9 and and CC cord-335975-m6lkrehi 952 10 Lyon Lyon NNP cord-335975-m6lkrehi 952 11 , , , cord-335975-m6lkrehi 952 12 from from IN cord-335975-m6lkrehi 952 13 2010 2010 CD cord-335975-m6lkrehi 952 14 to to IN cord-335975-m6lkrehi 952 15 2017 2017 CD cord-335975-m6lkrehi 952 16 . . . cord-335975-m6lkrehi 953 1 Endocrine endocrine JJ cord-335975-m6lkrehi 953 2 explorations exploration NNS cord-335975-m6lkrehi 953 3 at at IN cord-335975-m6lkrehi 953 4 the the DT cord-335975-m6lkrehi 953 5 second second JJ cord-335975-m6lkrehi 953 6 morning morning NN cord-335975-m6lkrehi 953 7 following follow VBG cord-335975-m6lkrehi 953 8 admission admission NN cord-335975-m6lkrehi 953 9 and and CC cord-335975-m6lkrehi 953 10 24 24 CD cord-335975-m6lkrehi 953 11 h h NN cord-335975-m6lkrehi 953 12 before before IN cord-335975-m6lkrehi 953 13 discharge discharge NN cord-335975-m6lkrehi 953 14 were be VBD cord-335975-m6lkrehi 953 15 performed perform VBN cord-335975-m6lkrehi 953 16 - - HYPH cord-335975-m6lkrehi 953 17 cortisol cortisol NN cord-335975-m6lkrehi 953 18 24 24 CD cord-335975-m6lkrehi 953 19 h h NN cord-335975-m6lkrehi 953 20 cycle cycle NN cord-335975-m6lkrehi 953 21 with with IN cord-335975-m6lkrehi 953 22 free free JJ cord-335975-m6lkrehi 953 23 cortisol cortisol NN cord-335975-m6lkrehi 953 24 and and CC cord-335975-m6lkrehi 953 25 ACTH ACTH NNP cord-335975-m6lkrehi 953 26 dosages dosage NNS cord-335975-m6lkrehi 953 27 every every DT cord-335975-m6lkrehi 953 28 4 4 CD cord-335975-m6lkrehi 953 29 h h NN cord-335975-m6lkrehi 953 30 ( ( -LRB- cord-335975-m6lkrehi 953 31 or or CC cord-335975-m6lkrehi 953 32 6 6 CD cord-335975-m6lkrehi 953 33 h h NN cord-335975-m6lkrehi 953 34 if if IN cord-335975-m6lkrehi 953 35 no no DT cord-335975-m6lkrehi 953 36 central central JJ cord-335975-m6lkrehi 953 37 line line NN cord-335975-m6lkrehi 953 38 ) ) -RRB- cord-335975-m6lkrehi 954 1 + + CC cord-335975-m6lkrehi 954 2 free free JJ cord-335975-m6lkrehi 954 3 24H 24H NNP cord-335975-m6lkrehi 954 4 urinary urinary JJ cord-335975-m6lkrehi 954 5 cortisol cortisol NN cord-335975-m6lkrehi 954 6 + + CC cord-335975-m6lkrehi 954 7 TSH TSH NNP cord-335975-m6lkrehi 954 8 and and CC cord-335975-m6lkrehi 954 9 T4L t4l NN cord-335975-m6lkrehi 954 10 , , , cord-335975-m6lkrehi 954 11 24H 24H NNP cord-335975-m6lkrehi 954 12 urinary urinary JJ cord-335975-m6lkrehi 954 13 LH LH NNP cord-335975-m6lkrehi 954 14 and and CC cord-335975-m6lkrehi 954 15 FSH fsh NN cord-335975-m6lkrehi 954 16 , , , cord-335975-m6lkrehi 954 17 blood blood NN cord-335975-m6lkrehi 954 18 level level NN cord-335975-m6lkrehi 954 19 of of IN cord-335975-m6lkrehi 954 20 testosterone testosterone NN cord-335975-m6lkrehi 954 21 or or CC cord-335975-m6lkrehi 954 22 estradiol estradiol NN cord-335975-m6lkrehi 954 23 for for IN cord-335975-m6lkrehi 954 24 children child NNS cord-335975-m6lkrehi 954 25 aged age VBN cord-335975-m6lkrehi 954 26 > > SYM cord-335975-m6lkrehi 954 27 10 10 CD cord-335975-m6lkrehi 954 28 years year NNS cord-335975-m6lkrehi 954 29 , , , cord-335975-m6lkrehi 954 30 and and CC cord-335975-m6lkrehi 954 31 IGF1 IGF1 NNP cord-335975-m6lkrehi 954 32 . . . cord-335975-m6lkrehi 955 1 Patients patient NNS cord-335975-m6lkrehi 955 2 were be VBD cord-335975-m6lkrehi 955 3 classified classify VBN cord-335975-m6lkrehi 955 4 as as IN cord-335975-m6lkrehi 955 5 having have VBG cord-335975-m6lkrehi 955 6 cortisol cortisol NN cord-335975-m6lkrehi 955 7 insufficiency insufficiency NN cord-335975-m6lkrehi 955 8 if if IN cord-335975-m6lkrehi 955 9 all all PDT cord-335975-m6lkrehi 955 10 the the DT cord-335975-m6lkrehi 955 11 cortisol cortisol NN cord-335975-m6lkrehi 955 12 dosages dosage NNS cord-335975-m6lkrehi 955 13 were be VBD cord-335975-m6lkrehi 956 1 < < XX cord-335975-m6lkrehi 956 2 200 200 CD cord-335975-m6lkrehi 956 3 nmol nmol NNP cord-335975-m6lkrehi 956 4 l l NN cord-335975-m6lkrehi 956 5 and and CC cord-335975-m6lkrehi 956 6 all all DT cord-335975-m6lkrehi 956 7 ACTH ACTH NNP cord-335975-m6lkrehi 956 8 were be VBD cord-335975-m6lkrehi 956 9 < < NNP cord-335975-m6lkrehi 956 10 12 12 CD cord-335975-m6lkrehi 956 11 pg pg NN cord-335975-m6lkrehi 956 12 l. l. NN cord-335975-m6lkrehi 956 13 TSH TSH NNP cord-335975-m6lkrehi 956 14 deficiency deficiency NN cord-335975-m6lkrehi 956 15 was be VBD cord-335975-m6lkrehi 956 16 defined define VBN cord-335975-m6lkrehi 956 17 as as IN cord-335975-m6lkrehi 956 18 T4 T4 NNP cord-335975-m6lkrehi 956 19 l l NNP cord-335975-m6lkrehi 956 20 < < NNP cord-335975-m6lkrehi 956 21 11.5 11.5 CD cord-335975-m6lkrehi 956 22 pmol pmol NN cord-335975-m6lkrehi 956 23 l l NN cord-335975-m6lkrehi 956 24 and and CC cord-335975-m6lkrehi 956 25 TSH TSH NNP cord-335975-m6lkrehi 956 26 < < XX cord-335975-m6lkrehi 956 27 4.2 4.2 CD cord-335975-m6lkrehi 956 28 mUI mui NN cord-335975-m6lkrehi 956 29 l. l. NNP cord-335975-m6lkrehi 956 30 _SP cord-335975-m6lkrehi 957 1 Gonadotropin gonadotropin JJ cord-335975-m6lkrehi 957 2 defciency defciency NN cord-335975-m6lkrehi 957 3 was be VBD cord-335975-m6lkrehi 957 4 defined define VBN cord-335975-m6lkrehi 957 5 as as IN cord-335975-m6lkrehi 957 6 urinary urinary JJ cord-335975-m6lkrehi 957 7 LH LH NNP cord-335975-m6lkrehi 957 8 < < XX cord-335975-m6lkrehi 957 9 0.14 0.14 CD cord-335975-m6lkrehi 957 10 UI UI NNP cord-335975-m6lkrehi 957 11 24 24 CD cord-335975-m6lkrehi 957 12 h h NN cord-335975-m6lkrehi 957 13 and and CC cord-335975-m6lkrehi 957 14 urinary urinary JJ cord-335975-m6lkrehi 957 15 FSH FSH NNP cord-335975-m6lkrehi 957 16 < < XX cord-335975-m6lkrehi 957 17 1.52 1.52 CD cord-335975-m6lkrehi 957 18 UI UI NNP cord-335975-m6lkrehi 957 19 24 24 CD cord-335975-m6lkrehi 957 20 h h NN cord-335975-m6lkrehi 957 21 for for IN cord-335975-m6lkrehi 957 22 males male NNS cord-335975-m6lkrehi 957 23 + + CC cord-335975-m6lkrehi 957 24 urinary urinary JJ cord-335975-m6lkrehi 957 25 LH lh NN cord-335975-m6lkrehi 957 26 < < XX cord-335975-m6lkrehi 957 27 0.018 0.018 CD cord-335975-m6lkrehi 957 28 UI UI NNP cord-335975-m6lkrehi 957 29 24 24 CD cord-335975-m6lkrehi 957 30 h h NN cord-335975-m6lkrehi 957 31 and and CC cord-335975-m6lkrehi 957 32 urinary urinary JJ cord-335975-m6lkrehi 957 33 FSH FSH NNP cord-335975-m6lkrehi 957 34 < < XX cord-335975-m6lkrehi 957 35 2.24 2.24 CD cord-335975-m6lkrehi 957 36 UI UI NNP cord-335975-m6lkrehi 957 37 24H 24H NNP cord-335975-m6lkrehi 957 38 in in IN cord-335975-m6lkrehi 957 39 female female NN cord-335975-m6lkrehi 957 40 . . . cord-335975-m6lkrehi 958 1 Patients patient NNS cord-335975-m6lkrehi 958 2 with with IN cord-335975-m6lkrehi 958 3 deficiency deficiency NN cord-335975-m6lkrehi 958 4 ( ( -LRB- cord-335975-m6lkrehi 958 5 ACTH ACTH NNP cord-335975-m6lkrehi 958 6 and and CC cord-335975-m6lkrehi 958 7 any any DT cord-335975-m6lkrehi 958 8 deficiency deficiency NN cord-335975-m6lkrehi 958 9 ) ) -RRB- cord-335975-m6lkrehi 958 10 were be VBD cord-335975-m6lkrehi 958 11 compared compare VBN cord-335975-m6lkrehi 958 12 to to IN cord-335975-m6lkrehi 958 13 those those DT cord-335975-m6lkrehi 958 14 without without IN cord-335975-m6lkrehi 958 15 deficiency deficiency NN cord-335975-m6lkrehi 958 16 in in IN cord-335975-m6lkrehi 958 17 terms term NNS cord-335975-m6lkrehi 958 18 of of IN cord-335975-m6lkrehi 958 19 hemodynamic hemodynamic JJ cord-335975-m6lkrehi 958 20 instability instability NN cord-335975-m6lkrehi 958 21 , , , cord-335975-m6lkrehi 958 22 respiratory respiratory JJ cord-335975-m6lkrehi 958 23 instability instability NN cord-335975-m6lkrehi 958 24 , , , cord-335975-m6lkrehi 958 25 neurological neurological JJ cord-335975-m6lkrehi 958 26 and and CC cord-335975-m6lkrehi 958 27 infectious infectious JJ cord-335975-m6lkrehi 958 28 complications complication NNS cord-335975-m6lkrehi 958 29 For for IN cord-335975-m6lkrehi 958 30 continuous continuous JJ cord-335975-m6lkrehi 958 31 variables variable NNS cord-335975-m6lkrehi 958 32 means mean VBZ cord-335975-m6lkrehi 958 33 and and CC cord-335975-m6lkrehi 958 34 95 95 CD cord-335975-m6lkrehi 958 35 % % NN cord-335975-m6lkrehi 958 36 confidence confidence NN cord-335975-m6lkrehi 958 37 interval interval NN cord-335975-m6lkrehi 958 38 were be VBD cord-335975-m6lkrehi 958 39 calculated calculate VBN cord-335975-m6lkrehi 958 40 and and CC cord-335975-m6lkrehi 958 41 compared compare VBN cord-335975-m6lkrehi 958 42 by by IN cord-335975-m6lkrehi 958 43 t t NNP cord-335975-m6lkrehi 958 44 student student NN cord-335975-m6lkrehi 958 45 test test NN cord-335975-m6lkrehi 958 46 . . . cord-335975-m6lkrehi 959 1 Chi-2 Chi-2 NNP cord-335975-m6lkrehi 959 2 test test NN cord-335975-m6lkrehi 959 3 was be VBD cord-335975-m6lkrehi 959 4 used use VBN cord-335975-m6lkrehi 959 5 to to TO cord-335975-m6lkrehi 959 6 compare compare VB cord-335975-m6lkrehi 959 7 proportions proportion NNS cord-335975-m6lkrehi 959 8 . . . cord-335975-m6lkrehi 960 1 Results result NNS cord-335975-m6lkrehi 960 2 : : : cord-335975-m6lkrehi 961 1 Among among IN cord-335975-m6lkrehi 961 2 the the DT cord-335975-m6lkrehi 961 3 110 110 CD cord-335975-m6lkrehi 961 4 patients patient NNS cord-335975-m6lkrehi 961 5 evaluated evaluate VBN cord-335975-m6lkrehi 961 6 , , , cord-335975-m6lkrehi 961 7 12 12 CD cord-335975-m6lkrehi 961 8 had have VBD cord-335975-m6lkrehi 961 9 ACTH ACTH NNP cord-335975-m6lkrehi 961 10 deficiency deficiency NN cord-335975-m6lkrehi 961 11 , , , cord-335975-m6lkrehi 961 12 and and CC cord-335975-m6lkrehi 961 13 23 23 CD cord-335975-m6lkrehi 961 14 had have VBD cord-335975-m6lkrehi 961 15 at at RB cord-335975-m6lkrehi 961 16 least least RBS cord-335975-m6lkrehi 961 17 one one CD cord-335975-m6lkrehi 961 18 acute acute JJ cord-335975-m6lkrehi 961 19 pituitary pituitary JJ cord-335975-m6lkrehi 961 20 dysfunction dysfunction NN cord-335975-m6lkrehi 961 21 . . . cord-335975-m6lkrehi 962 1 Comparison comparison NN cord-335975-m6lkrehi 962 2 of of IN cord-335975-m6lkrehi 962 3 patients patient NNS cord-335975-m6lkrehi 962 4 who who WP cord-335975-m6lkrehi 962 5 presented present VBD cord-335975-m6lkrehi 962 6 ACTH ACTH NNP cord-335975-m6lkrehi 962 7 deficiency deficiency NN cord-335975-m6lkrehi 962 8 with with IN cord-335975-m6lkrehi 962 9 those those DT cord-335975-m6lkrehi 962 10 who who WP cord-335975-m6lkrehi 962 11 were be VBD cord-335975-m6lkrehi 962 12 not not RB cord-335975-m6lkrehi 962 13 deficient deficient JJ cord-335975-m6lkrehi 962 14 found find VBN cord-335975-m6lkrehi 962 15 no no DT cord-335975-m6lkrehi 962 16 differences difference NNS cord-335975-m6lkrehi 962 17 in in IN cord-335975-m6lkrehi 962 18 terms term NNS cord-335975-m6lkrehi 962 19 of of IN cord-335975-m6lkrehi 962 20 patients patient NNS cord-335975-m6lkrehi 962 21 characteristics characteristic NNS cord-335975-m6lkrehi 962 22 , , , cord-335975-m6lkrehi 962 23 cause cause NN cord-335975-m6lkrehi 962 24 of of IN cord-335975-m6lkrehi 962 25 TBI TBI NNP cord-335975-m6lkrehi 962 26 , , , cord-335975-m6lkrehi 962 27 level level NN cord-335975-m6lkrehi 962 28 of of IN cord-335975-m6lkrehi 962 29 severity severity NN cord-335975-m6lkrehi 962 30 and and CC cord-335975-m6lkrehi 962 31 level level NN cord-335975-m6lkrehi 962 32 of of IN cord-335975-m6lkrehi 962 33 injury injury NN cord-335975-m6lkrehi 962 34 . . . cord-335975-m6lkrehi 963 1 Paitents Paitents NNP cord-335975-m6lkrehi 963 2 with with IN cord-335975-m6lkrehi 963 3 ACTH ACTH NNP cord-335975-m6lkrehi 963 4 deficiency deficiency NN cord-335975-m6lkrehi 963 5 required require VBD cord-335975-m6lkrehi 963 6 more more RBR cord-335975-m6lkrehi 963 7 frequently frequently RB cord-335975-m6lkrehi 963 8 fluid fluid JJ cord-335975-m6lkrehi 963 9 bolus bolus NN cord-335975-m6lkrehi 963 10 at at IN cord-335975-m6lkrehi 963 11 day2 day2 NNP cord-335975-m6lkrehi 963 12 ( ( -LRB- cord-335975-m6lkrehi 963 13 67 67 CD cord-335975-m6lkrehi 963 14 vs vs IN cord-335975-m6lkrehi 963 15 34 34 CD cord-335975-m6lkrehi 963 16 % % NN cord-335975-m6lkrehi 963 17 , , , cord-335975-m6lkrehi 963 18 p p NN cord-335975-m6lkrehi 963 19 = = SYM cord-335975-m6lkrehi 963 20 0.03 0.03 CD cord-335975-m6lkrehi 963 21 ) ) -RRB- cord-335975-m6lkrehi 963 22 . . . cord-335975-m6lkrehi 964 1 All all PDT cord-335975-m6lkrehi 964 2 the the DT cord-335975-m6lkrehi 964 3 markers marker NNS cord-335975-m6lkrehi 964 4 of of IN cord-335975-m6lkrehi 964 5 severity severity NN cord-335975-m6lkrehi 964 6 were be VBD cord-335975-m6lkrehi 964 7 higher high JJR cord-335975-m6lkrehi 964 8 and and CC cord-335975-m6lkrehi 964 9 the the DT cord-335975-m6lkrehi 964 10 need need NN cord-335975-m6lkrehi 964 11 of of IN cord-335975-m6lkrehi 964 12 vasoactive vasoactive JJ cord-335975-m6lkrehi 964 13 drugs drug NNS cord-335975-m6lkrehi 964 14 were be VBD cord-335975-m6lkrehi 964 15 more more RBR cord-335975-m6lkrehi 964 16 frequent frequent JJ cord-335975-m6lkrehi 964 17 but but CC cord-335975-m6lkrehi 964 18 the the DT cord-335975-m6lkrehi 964 19 differences difference NNS cord-335975-m6lkrehi 964 20 were be VBD cord-335975-m6lkrehi 964 21 not not RB cord-335975-m6lkrehi 964 22 statistically statistically RB cord-335975-m6lkrehi 964 23 significant significant JJ cord-335975-m6lkrehi 964 24 . . . cord-335975-m6lkrehi 965 1 Table table NN cord-335975-m6lkrehi 965 2 1 1 CD cord-335975-m6lkrehi 965 3 shows show VBZ cord-335975-m6lkrehi 965 4 comparison comparison NN cord-335975-m6lkrehi 965 5 between between IN cord-335975-m6lkrehi 965 6 patients patient NNS cord-335975-m6lkrehi 965 7 with with IN cord-335975-m6lkrehi 965 8 at at RB cord-335975-m6lkrehi 965 9 least least RBS cord-335975-m6lkrehi 965 10 one one CD cord-335975-m6lkrehi 965 11 pituitary pituitary JJ cord-335975-m6lkrehi 965 12 hormone hormone NN cord-335975-m6lkrehi 965 13 deficiency deficiency NN cord-335975-m6lkrehi 965 14 to to IN cord-335975-m6lkrehi 965 15 those those DT cord-335975-m6lkrehi 965 16 without without IN cord-335975-m6lkrehi 965 17 deficiency deficiency NN cord-335975-m6lkrehi 965 18 . . . cord-335975-m6lkrehi 966 1 The the DT cord-335975-m6lkrehi 966 2 same same JJ cord-335975-m6lkrehi 966 3 result result NN cord-335975-m6lkrehi 966 4 was be VBD cord-335975-m6lkrehi 966 5 found find VBN cord-335975-m6lkrehi 966 6 . . . cord-335975-m6lkrehi 967 1 Glycemia glycemia NN cord-335975-m6lkrehi 967 2 levels level NNS cord-335975-m6lkrehi 967 3 were be VBD cord-335975-m6lkrehi 967 4 lower low JJR cord-335975-m6lkrehi 967 5 in in IN cord-335975-m6lkrehi 967 6 the the DT cord-335975-m6lkrehi 967 7 group group NN cord-335975-m6lkrehi 967 8 with with IN cord-335975-m6lkrehi 967 9 deficiency deficiency NN cord-335975-m6lkrehi 967 10 . . . cord-335975-m6lkrehi 968 1 Conclusion conclusion NN cord-335975-m6lkrehi 968 2 : : : cord-335975-m6lkrehi 968 3 We -PRON- PRP cord-335975-m6lkrehi 968 4 did do VBD cord-335975-m6lkrehi 968 5 n't not RB cord-335975-m6lkrehi 968 6 find find VB cord-335975-m6lkrehi 968 7 any any DT cord-335975-m6lkrehi 968 8 predictive predictive JJ cord-335975-m6lkrehi 968 9 factors factor NNS cord-335975-m6lkrehi 968 10 of of IN cord-335975-m6lkrehi 968 11 pituitary pituitary JJ cord-335975-m6lkrehi 968 12 hormone hormone NN cord-335975-m6lkrehi 968 13 deficiency deficiency NN cord-335975-m6lkrehi 968 14 in in IN cord-335975-m6lkrehi 968 15 children child NNS cord-335975-m6lkrehi 968 16 with with IN cord-335975-m6lkrehi 968 17 moderate moderate JJ cord-335975-m6lkrehi 968 18 - - HYPH cord-335975-m6lkrehi 968 19 severe severe JJ cord-335975-m6lkrehi 968 20 TBI tbi NN cord-335975-m6lkrehi 968 21 justifying justify VBG cord-335975-m6lkrehi 968 22 a a DT cord-335975-m6lkrehi 968 23 systematic systematic JJ cord-335975-m6lkrehi 968 24 screening screening NN cord-335975-m6lkrehi 968 25 of of IN cord-335975-m6lkrehi 968 26 those those DT cord-335975-m6lkrehi 968 27 patients patient NNS cord-335975-m6lkrehi 968 28 . . . cord-335975-m6lkrehi 969 1 Introduction introduction NN cord-335975-m6lkrehi 969 2 : : : cord-335975-m6lkrehi 970 1 Most most RBS cord-335975-m6lkrehi 970 2 intensive intensive JJ cord-335975-m6lkrehi 970 3 care care NN cord-335975-m6lkrehi 970 4 unit unit NN cord-335975-m6lkrehi 970 5 ( ( -LRB- cord-335975-m6lkrehi 970 6 ICU ICU NNP cord-335975-m6lkrehi 970 7 ) ) -RRB- cord-335975-m6lkrehi 970 8 patients patient NNS cord-335975-m6lkrehi 970 9 can can MD cord-335975-m6lkrehi 970 10 not not RB cord-335975-m6lkrehi 970 11 make make VB cord-335975-m6lkrehi 970 12 decisions decision NNS cord-335975-m6lkrehi 970 13 themselves -PRON- PRP cord-335975-m6lkrehi 970 14 . . . cord-335975-m6lkrehi 971 1 Familiy Familiy NNP cord-335975-m6lkrehi 971 2 members member NNS cord-335975-m6lkrehi 971 3 are be VBP cord-335975-m6lkrehi 971 4 actively actively RB cord-335975-m6lkrehi 971 5 involved involve VBN cord-335975-m6lkrehi 971 6 in in IN cord-335975-m6lkrehi 971 7 the the DT cord-335975-m6lkrehi 971 8 care care NN cord-335975-m6lkrehi 971 9 process process NN cord-335975-m6lkrehi 971 10 as as IN cord-335975-m6lkrehi 971 11 surrogate surrogate JJ cord-335975-m6lkrehi 971 12 decision decision NN cord-335975-m6lkrehi 971 13 - - HYPH cord-335975-m6lkrehi 971 14 makers maker NNS cord-335975-m6lkrehi 971 15 and and CC cord-335975-m6lkrehi 971 16 judges judge NNS cord-335975-m6lkrehi 971 17 of of IN cord-335975-m6lkrehi 971 18 care care NN cord-335975-m6lkrehi 971 19 quality quality NN cord-335975-m6lkrehi 971 20 . . . cord-335975-m6lkrehi 972 1 However however RB cord-335975-m6lkrehi 972 2 , , , cord-335975-m6lkrehi 972 3 family family NN cord-335975-m6lkrehi 972 4 satisfaction satisfaction NN cord-335975-m6lkrehi 972 5 with with IN cord-335975-m6lkrehi 972 6 care care NN cord-335975-m6lkrehi 972 7 is be VBZ cord-335975-m6lkrehi 972 8 complex complex JJ cord-335975-m6lkrehi 972 9 and and CC cord-335975-m6lkrehi 972 10 is be VBZ cord-335975-m6lkrehi 972 11 not not RB cord-335975-m6lkrehi 972 12 clearly clearly RB cord-335975-m6lkrehi 972 13 defined define VBN cord-335975-m6lkrehi 972 14 . . . cord-335975-m6lkrehi 973 1 The the DT cord-335975-m6lkrehi 973 2 aim aim NN cord-335975-m6lkrehi 973 3 of of IN cord-335975-m6lkrehi 973 4 this this DT cord-335975-m6lkrehi 973 5 study study NN cord-335975-m6lkrehi 973 6 is be VBZ cord-335975-m6lkrehi 973 7 to to TO cord-335975-m6lkrehi 973 8 evaluate evaluate VB cord-335975-m6lkrehi 973 9 the the DT cord-335975-m6lkrehi 973 10 different different JJ cord-335975-m6lkrehi 973 11 procedures procedure NNS cord-335975-m6lkrehi 973 12 ( ( -LRB- cord-335975-m6lkrehi 973 13 reception reception NN cord-335975-m6lkrehi 973 14 book book NN cord-335975-m6lkrehi 973 15 and and CC cord-335975-m6lkrehi 973 16 staff staff NN cord-335975-m6lkrehi 973 17 education education NN cord-335975-m6lkrehi 973 18 for for IN cord-335975-m6lkrehi 973 19 aid aid NN cord-335975-m6lkrehi 973 20 and and CC cord-335975-m6lkrehi 973 21 relationship relationship NN cord-335975-m6lkrehi 973 22 ) ) -RRB- cord-335975-m6lkrehi 973 23 used use VBN cord-335975-m6lkrehi 973 24 in in IN cord-335975-m6lkrehi 973 25 a a DT cord-335975-m6lkrehi 973 26 new new JJ cord-335975-m6lkrehi 973 27 ICU ICU NNP cord-335975-m6lkrehi 973 28 to to TO cord-335975-m6lkrehi 973 29 improve improve VB cord-335975-m6lkrehi 973 30 the the DT cord-335975-m6lkrehi 973 31 family family NN cord-335975-m6lkrehi 973 32 care care NN cord-335975-m6lkrehi 973 33 . . . cord-335975-m6lkrehi 974 1 Patients patient NNS cord-335975-m6lkrehi 974 2 and and CC cord-335975-m6lkrehi 974 3 methods method NNS cord-335975-m6lkrehi 975 1 : : : cord-335975-m6lkrehi 975 2 We -PRON- PRP cord-335975-m6lkrehi 975 3 included include VBD cord-335975-m6lkrehi 975 4 in in IN cord-335975-m6lkrehi 975 5 our -PRON- PRP$ cord-335975-m6lkrehi 975 6 study study NN cord-335975-m6lkrehi 975 7 patients patient NNS cord-335975-m6lkrehi 975 8 who who WP cord-335975-m6lkrehi 975 9 had have VBD cord-335975-m6lkrehi 975 10 spent spend VBN cord-335975-m6lkrehi 975 11 more more JJR cord-335975-m6lkrehi 975 12 than than IN cord-335975-m6lkrehi 975 13 48 48 CD cord-335975-m6lkrehi 975 14 h h NN cord-335975-m6lkrehi 975 15 in in IN cord-335975-m6lkrehi 975 16 our -PRON- PRP$ cord-335975-m6lkrehi 975 17 department department NN cord-335975-m6lkrehi 975 18 . . . cord-335975-m6lkrehi 976 1 A a DT cord-335975-m6lkrehi 976 2 questionnairy questionnairy NNP cord-335975-m6lkrehi 976 3 , , , cord-335975-m6lkrehi 976 4 adapted adapt VBN cord-335975-m6lkrehi 976 5 to to IN cord-335975-m6lkrehi 976 6 our -PRON- PRP$ cord-335975-m6lkrehi 976 7 population population NN cord-335975-m6lkrehi 976 8 , , , cord-335975-m6lkrehi 976 9 was be VBD cord-335975-m6lkrehi 976 10 performed perform VBN cord-335975-m6lkrehi 976 11 by by IN cord-335975-m6lkrehi 976 12 our -PRON- PRP$ cord-335975-m6lkrehi 976 13 staff staff NN cord-335975-m6lkrehi 976 14 and and CC cord-335975-m6lkrehi 976 15 validated validate VBN cord-335975-m6lkrehi 976 16 by by IN cord-335975-m6lkrehi 976 17 the the DT cord-335975-m6lkrehi 976 18 Hygiene Hygiene NNP cord-335975-m6lkrehi 976 19 and and CC cord-335975-m6lkrehi 976 20 Quality Quality NNP cord-335975-m6lkrehi 976 21 Care Care NNP cord-335975-m6lkrehi 976 22 departement departement NN cord-335975-m6lkrehi 976 23 . . . cord-335975-m6lkrehi 977 1 We -PRON- PRP cord-335975-m6lkrehi 977 2 proceded procede VBD cord-335975-m6lkrehi 977 3 by by IN cord-335975-m6lkrehi 977 4 phone phone NN cord-335975-m6lkrehi 977 5 calls call NNS cord-335975-m6lkrehi 977 6 , , , cord-335975-m6lkrehi 977 7 10 10 CD cord-335975-m6lkrehi 977 8 months month NNS cord-335975-m6lkrehi 977 9 after after IN cord-335975-m6lkrehi 977 10 the the DT cord-335975-m6lkrehi 977 11 inauguration inauguration NN cord-335975-m6lkrehi 977 12 of of IN cord-335975-m6lkrehi 977 13 our -PRON- PRP$ cord-335975-m6lkrehi 977 14 ICU ICU NNP cord-335975-m6lkrehi 977 15 . . . cord-335975-m6lkrehi 978 1 Results result NNS cord-335975-m6lkrehi 978 2 : : : cord-335975-m6lkrehi 979 1 Sixty sixty CD cord-335975-m6lkrehi 979 2 - - HYPH cord-335975-m6lkrehi 979 3 five five CD cord-335975-m6lkrehi 979 4 questionnaires questionnaire NNS cord-335975-m6lkrehi 979 5 were be VBD cord-335975-m6lkrehi 979 6 included include VBN cord-335975-m6lkrehi 979 7 ( ( -LRB- cord-335975-m6lkrehi 979 8 Fig Fig NNP cord-335975-m6lkrehi 979 9 . . . cord-335975-m6lkrehi 979 10 1 1 CD cord-335975-m6lkrehi 979 11 ) ) -RRB- cord-335975-m6lkrehi 979 12 . . . cord-335975-m6lkrehi 980 1 The the DT cord-335975-m6lkrehi 980 2 average average NN cord-335975-m6lkrehi 980 3 of of IN cord-335975-m6lkrehi 980 4 age age NN cord-335975-m6lkrehi 980 5 was be VBD cord-335975-m6lkrehi 980 6 52 52 CD cord-335975-m6lkrehi 980 7 ± ± CD cord-335975-m6lkrehi 980 8 20 20 CD cord-335975-m6lkrehi 980 9 with with IN cord-335975-m6lkrehi 980 10 a a DT cord-335975-m6lkrehi 980 11 sex sex NN cord-335975-m6lkrehi 980 12 ratio ratio NN cord-335975-m6lkrehi 980 13 of of IN cord-335975-m6lkrehi 980 14 2 2 CD cord-335975-m6lkrehi 980 15 . . . cord-335975-m6lkrehi 981 1 The the DT cord-335975-m6lkrehi 981 2 average average NN cord-335975-m6lkrehi 981 3 of of IN cord-335975-m6lkrehi 981 4 the the DT cord-335975-m6lkrehi 981 5 simplified simplified JJ cord-335975-m6lkrehi 981 6 acute acute JJ cord-335975-m6lkrehi 981 7 physiology physiology NN cord-335975-m6lkrehi 981 8 score score NN cord-335975-m6lkrehi 981 9 ( ( -LRB- cord-335975-m6lkrehi 981 10 SAPSII SAPSII NNP cord-335975-m6lkrehi 981 11 ) ) -RRB- cord-335975-m6lkrehi 981 12 was be VBD cord-335975-m6lkrehi 981 13 36 36 CD cord-335975-m6lkrehi 981 14 ± ± NNP cord-335975-m6lkrehi 981 15 17 17 CD cord-335975-m6lkrehi 981 16 . . . cord-335975-m6lkrehi 982 1 The the DT cord-335975-m6lkrehi 982 2 median median NN cord-335975-m6lkrehi 982 3 stay stay NN cord-335975-m6lkrehi 982 4 was be VBD cord-335975-m6lkrehi 982 5 7 7 CD cord-335975-m6lkrehi 982 6 days day NNS cord-335975-m6lkrehi 982 7 [ [ -LRB- cord-335975-m6lkrehi 982 8 4 4 CD cord-335975-m6lkrehi 982 9 - - SYM cord-335975-m6lkrehi 982 10 16 16 CD cord-335975-m6lkrehi 982 11 ] ] -RRB- cord-335975-m6lkrehi 982 12 with with IN cord-335975-m6lkrehi 982 13 a a DT cord-335975-m6lkrehi 982 14 total total JJ cord-335975-m6lkrehi 982 15 mortality mortality NN cord-335975-m6lkrehi 982 16 rate rate NN cord-335975-m6lkrehi 982 17 of of IN cord-335975-m6lkrehi 982 18 25 25 CD cord-335975-m6lkrehi 982 19 % % NN cord-335975-m6lkrehi 982 20 . . . cord-335975-m6lkrehi 983 1 Mostly mostly RB cord-335975-m6lkrehi 983 2 , , , cord-335975-m6lkrehi 983 3 we -PRON- PRP cord-335975-m6lkrehi 983 4 interrogated interrogate VBD cord-335975-m6lkrehi 983 5 first first JJ cord-335975-m6lkrehi 983 6 - - HYPH cord-335975-m6lkrehi 983 7 degree degree NN cord-335975-m6lkrehi 983 8 parents parent NNS cord-335975-m6lkrehi 983 9 ( ( -LRB- cord-335975-m6lkrehi 983 10 n n NN cord-335975-m6lkrehi 983 11 = = SYM cord-335975-m6lkrehi 983 12 52 52 CD cord-335975-m6lkrehi 983 13 ) ) -RRB- cord-335975-m6lkrehi 983 14 . . . cord-335975-m6lkrehi 984 1 Only only RB cord-335975-m6lkrehi 984 2 three three CD cord-335975-m6lkrehi 984 3 families family NNS cord-335975-m6lkrehi 984 4 recieved recieve VBD cord-335975-m6lkrehi 984 5 reception reception NN cord-335975-m6lkrehi 984 6 book book NN cord-335975-m6lkrehi 984 7 at at IN cord-335975-m6lkrehi 984 8 admission admission NN cord-335975-m6lkrehi 984 9 . . . cord-335975-m6lkrehi 985 1 Visit visit VB cord-335975-m6lkrehi 985 2 in in IN cord-335975-m6lkrehi 985 3 patient patient JJ cord-335975-m6lkrehi 985 4 room room NN cord-335975-m6lkrehi 985 5 was be VBD cord-335975-m6lkrehi 985 6 autorised autorise VBN cord-335975-m6lkrehi 985 7 only only RB cord-335975-m6lkrehi 985 8 for for IN cord-335975-m6lkrehi 985 9 27 27 CD cord-335975-m6lkrehi 985 10 % % NN cord-335975-m6lkrehi 985 11 ( ( -LRB- cord-335975-m6lkrehi 985 12 n n NN cord-335975-m6lkrehi 985 13 = = SYM cord-335975-m6lkrehi 985 14 17 17 CD cord-335975-m6lkrehi 985 15 ) ) -RRB- cord-335975-m6lkrehi 985 16 of of IN cord-335975-m6lkrehi 985 17 family family NN cord-335975-m6lkrehi 985 18 members member NNS cord-335975-m6lkrehi 985 19 . . . cord-335975-m6lkrehi 986 1 Only only RB cord-335975-m6lkrehi 986 2 four four CD cord-335975-m6lkrehi 986 3 persons person NNS cord-335975-m6lkrehi 986 4 said say VBD cord-335975-m6lkrehi 986 5 they -PRON- PRP cord-335975-m6lkrehi 986 6 were be VBD cord-335975-m6lkrehi 986 7 disturbed disturb VBN cord-335975-m6lkrehi 986 8 in in IN cord-335975-m6lkrehi 986 9 visit visit NN cord-335975-m6lkrehi 986 10 hours hour NNS cord-335975-m6lkrehi 986 11 for for IN cord-335975-m6lkrehi 986 12 architectural architectural JJ cord-335975-m6lkrehi 986 13 reasons reason NNS cord-335975-m6lkrehi 986 14 ( ( -LRB- cord-335975-m6lkrehi 986 15 tight tight JJ cord-335975-m6lkrehi 986 16 space space NN cord-335975-m6lkrehi 986 17 ) ) -RRB- cord-335975-m6lkrehi 986 18 . . . cord-335975-m6lkrehi 987 1 Disponibility Disponibility NNP cord-335975-m6lkrehi 987 2 was be VBD cord-335975-m6lkrehi 987 3 found find VBN cord-335975-m6lkrehi 987 4 excellent excellent JJ cord-335975-m6lkrehi 987 5 in in IN cord-335975-m6lkrehi 987 6 40 40 CD cord-335975-m6lkrehi 987 7 % % NN cord-335975-m6lkrehi 987 8 ( ( -LRB- cord-335975-m6lkrehi 987 9 n n NN cord-335975-m6lkrehi 987 10 = = SYM cord-335975-m6lkrehi 987 11 24 24 CD cord-335975-m6lkrehi 987 12 ) ) -RRB- cord-335975-m6lkrehi 987 13 of of IN cord-335975-m6lkrehi 987 14 cases case NNS cord-335975-m6lkrehi 987 15 for for IN cord-335975-m6lkrehi 987 16 medical medical JJ cord-335975-m6lkrehi 987 17 staff staff NN cord-335975-m6lkrehi 987 18 , , , cord-335975-m6lkrehi 987 19 45 45 CD cord-335975-m6lkrehi 987 20 % % NN cord-335975-m6lkrehi 987 21 ( ( -LRB- cord-335975-m6lkrehi 987 22 n n NN cord-335975-m6lkrehi 987 23 = = SYM cord-335975-m6lkrehi 987 24 26 26 CD cord-335975-m6lkrehi 987 25 ) ) -RRB- cord-335975-m6lkrehi 987 26 for for IN cord-335975-m6lkrehi 987 27 paramedicals paramedical NNS cord-335975-m6lkrehi 987 28 . . . cord-335975-m6lkrehi 988 1 Informations information NNS cord-335975-m6lkrehi 988 2 provided provide VBN cord-335975-m6lkrehi 988 3 by by IN cord-335975-m6lkrehi 988 4 physicians physician NNS cord-335975-m6lkrehi 988 5 were be VBD cord-335975-m6lkrehi 988 6 clear clear JJ cord-335975-m6lkrehi 988 7 in in IN cord-335975-m6lkrehi 988 8 71.5 71.5 CD cord-335975-m6lkrehi 988 9 % % NN cord-335975-m6lkrehi 988 10 ( ( -LRB- cord-335975-m6lkrehi 988 11 n n NN cord-335975-m6lkrehi 988 12 = = SYM cord-335975-m6lkrehi 988 13 53 53 CD cord-335975-m6lkrehi 988 14 ) ) -RRB- cord-335975-m6lkrehi 988 15 of of IN cord-335975-m6lkrehi 988 16 cases case NNS cord-335975-m6lkrehi 988 17 . . . cord-335975-m6lkrehi 989 1 Fifteen fifteen CD cord-335975-m6lkrehi 989 2 of of IN cord-335975-m6lkrehi 989 3 the the DT cord-335975-m6lkrehi 989 4 family family NN cord-335975-m6lkrehi 989 5 members member NNS cord-335975-m6lkrehi 989 6 ( ( -LRB- cord-335975-m6lkrehi 989 7 23 23 CD cord-335975-m6lkrehi 989 8 % % NN cord-335975-m6lkrehi 989 9 ) ) -RRB- cord-335975-m6lkrehi 989 10 asked ask VBN cord-335975-m6lkrehi 989 11 psychology psychology NN cord-335975-m6lkrehi 989 12 support support NN cord-335975-m6lkrehi 989 13 . . . cord-335975-m6lkrehi 990 1 Patients patient NNS cord-335975-m6lkrehi 990 2 were be VBD cord-335975-m6lkrehi 990 3 followed follow VBN cord-335975-m6lkrehi 990 4 up up RP cord-335975-m6lkrehi 990 5 via via IN cord-335975-m6lkrehi 990 6 phone phone NN cord-335975-m6lkrehi 990 7 calls call NNS cord-335975-m6lkrehi 990 8 during during IN cord-335975-m6lkrehi 990 9 1 1 CD cord-335975-m6lkrehi 990 10 year year NN cord-335975-m6lkrehi 990 11 after after IN cord-335975-m6lkrehi 990 12 discharge discharge NN cord-335975-m6lkrehi 990 13 . . . cord-335975-m6lkrehi 991 1 Characteristics characteristic NNS cord-335975-m6lkrehi 991 2 on on IN cord-335975-m6lkrehi 991 3 admission admission NN cord-335975-m6lkrehi 991 4 and and CC cord-335975-m6lkrehi 991 5 outcomes outcome NNS cord-335975-m6lkrehi 991 6 after after IN cord-335975-m6lkrehi 991 7 discharge discharge NN cord-335975-m6lkrehi 991 8 were be VBD cord-335975-m6lkrehi 991 9 analyzed analyze VBN cord-335975-m6lkrehi 991 10 stratified stratified JJ cord-335975-m6lkrehi 991 11 by by IN cord-335975-m6lkrehi 991 12 ventilation ventilation NN cord-335975-m6lkrehi 991 13 modality modality NN cord-335975-m6lkrehi 991 14 NIV NIV NNP cord-335975-m6lkrehi 991 15 vs vs IN cord-335975-m6lkrehi 991 16 IMV IMV NNP cord-335975-m6lkrehi 991 17 . . . cord-335975-m6lkrehi 992 1 The the DT cord-335975-m6lkrehi 992 2 overall overall JJ cord-335975-m6lkrehi 992 3 survival survival NN cord-335975-m6lkrehi 992 4 was be VBD cord-335975-m6lkrehi 992 5 analyzed analyze VBN cord-335975-m6lkrehi 992 6 on on IN cord-335975-m6lkrehi 992 7 the the DT cord-335975-m6lkrehi 992 8 basis basis NN cord-335975-m6lkrehi 992 9 of of IN cord-335975-m6lkrehi 992 10 the the DT cord-335975-m6lkrehi 992 11 Kaplan Kaplan NNP cord-335975-m6lkrehi 992 12 - - HYPH cord-335975-m6lkrehi 992 13 Meier Meier NNP cord-335975-m6lkrehi 992 14 curves curve NNS cord-335975-m6lkrehi 992 15 . . . cord-335975-m6lkrehi 993 1 Results result NNS cord-335975-m6lkrehi 993 2 : : : cord-335975-m6lkrehi 993 3 During during IN cord-335975-m6lkrehi 993 4 the the DT cord-335975-m6lkrehi 993 5 predetermined predetermined JJ cord-335975-m6lkrehi 993 6 period period NN cord-335975-m6lkrehi 993 7 of of IN cord-335975-m6lkrehi 993 8 data datum NNS cord-335975-m6lkrehi 993 9 collection collection NN cord-335975-m6lkrehi 993 10 , , , cord-335975-m6lkrehi 993 11 the the DT cord-335975-m6lkrehi 993 12 follow follow NN cord-335975-m6lkrehi 993 13 - - HYPH cord-335975-m6lkrehi 993 14 up up NN cord-335975-m6lkrehi 993 15 involved involve VBD cord-335975-m6lkrehi 993 16 60 60 CD cord-335975-m6lkrehi 993 17 patients patient NNS cord-335975-m6lkrehi 993 18 . . . cord-335975-m6lkrehi 994 1 24 24 CD cord-335975-m6lkrehi 994 2 patients patient NNS cord-335975-m6lkrehi 994 3 were be VBD cord-335975-m6lkrehi 994 4 treated treat VBN cord-335975-m6lkrehi 994 5 by by IN cord-335975-m6lkrehi 994 6 NIV NIV NNP cord-335975-m6lkrehi 994 7 ( ( -LRB- cord-335975-m6lkrehi 994 8 group1 group1 NNP cord-335975-m6lkrehi 994 9 ) ) -RRB- cord-335975-m6lkrehi 994 10 and and CC cord-335975-m6lkrehi 994 11 36 36 CD cord-335975-m6lkrehi 994 12 patients patient NNS cord-335975-m6lkrehi 994 13 needed need VBD cord-335975-m6lkrehi 994 14 IMV IMV NNP cord-335975-m6lkrehi 994 15 ( ( -LRB- cord-335975-m6lkrehi 994 16 group2 group2 NN cord-335975-m6lkrehi 994 17 ) ) -RRB- cord-335975-m6lkrehi 994 18 . . . cord-335975-m6lkrehi 995 1 There there EX cord-335975-m6lkrehi 995 2 was be VBD cord-335975-m6lkrehi 995 3 no no DT cord-335975-m6lkrehi 995 4 difference difference NN cord-335975-m6lkrehi 995 5 between between IN cord-335975-m6lkrehi 995 6 the the DT cord-335975-m6lkrehi 995 7 2 2 CD cord-335975-m6lkrehi 995 8 groups group NNS cord-335975-m6lkrehi 995 9 in in IN cord-335975-m6lkrehi 995 10 age age NN cord-335975-m6lkrehi 995 11 ( ( -LRB- cord-335975-m6lkrehi 995 12 p p NN cord-335975-m6lkrehi 995 13 = = SYM cord-335975-m6lkrehi 995 14 0.69 0.69 CD cord-335975-m6lkrehi 995 15 ) ) -RRB- cord-335975-m6lkrehi 995 16 , , , cord-335975-m6lkrehi 995 17 severity severity NN cord-335975-m6lkrehi 995 18 of of IN cord-335975-m6lkrehi 995 19 COPD COPD NNP cord-335975-m6lkrehi 995 20 ( ( -LRB- cord-335975-m6lkrehi 995 21 p p NN cord-335975-m6lkrehi 995 22 = = SYM cord-335975-m6lkrehi 995 23 0.39 0.39 CD cord-335975-m6lkrehi 995 24 ) ) -RRB- cord-335975-m6lkrehi 995 25 , , , cord-335975-m6lkrehi 995 26 physiological physiological JJ cord-335975-m6lkrehi 995 27 reserve reserve NN cord-335975-m6lkrehi 995 28 at at IN cord-335975-m6lkrehi 995 29 discharge discharge NN cord-335975-m6lkrehi 995 30 ( ( -LRB- cord-335975-m6lkrehi 995 31 p p NN cord-335975-m6lkrehi 995 32 = = SYM cord-335975-m6lkrehi 995 33 0.14 0.14 CD cord-335975-m6lkrehi 995 34 ) ) -RRB- cord-335975-m6lkrehi 995 35 and and CC cord-335975-m6lkrehi 995 36 ICU ICU NNP cord-335975-m6lkrehi 995 37 readmission readmission NN cord-335975-m6lkrehi 995 38 ( ( -LRB- cord-335975-m6lkrehi 995 39 p p NN cord-335975-m6lkrehi 995 40 = = SYM cord-335975-m6lkrehi 995 41 1 1 CD cord-335975-m6lkrehi 995 42 ) ) -RRB- cord-335975-m6lkrehi 995 43 . . . cord-335975-m6lkrehi 996 1 Short short JJ cord-335975-m6lkrehi 996 2 term term NN cord-335975-m6lkrehi 996 3 outcomes outcome NNS cord-335975-m6lkrehi 996 4 were be VBD cord-335975-m6lkrehi 996 5 not not RB cord-335975-m6lkrehi 996 6 different different JJ cord-335975-m6lkrehi 996 7 between between IN cord-335975-m6lkrehi 996 8 the the DT cord-335975-m6lkrehi 996 9 2 2 CD cord-335975-m6lkrehi 996 10 groups-1-month groups-1-month NNP cord-335975-m6lkrehi 996 11 readmission readmission NN cord-335975-m6lkrehi 996 12 ( ( -LRB- cord-335975-m6lkrehi 996 13 16.7 16.7 CD cord-335975-m6lkrehi 996 14 vs vs IN cord-335975-m6lkrehi 996 15 25 25 CD cord-335975-m6lkrehi 996 16 % % NN cord-335975-m6lkrehi 996 17 respectively respectively RB cord-335975-m6lkrehi 996 18 in in IN cord-335975-m6lkrehi 996 19 NIV NIV NNP cord-335975-m6lkrehi 996 20 and and CC cord-335975-m6lkrehi 996 21 IMV IMV NNP cord-335975-m6lkrehi 996 22 , , , cord-335975-m6lkrehi 996 23 p p NN cord-335975-m6lkrehi 996 24 = = SYM cord-335975-m6lkrehi 996 25 0.52 0.52 CD cord-335975-m6lkrehi 996 26 ) ) -RRB- cord-335975-m6lkrehi 996 27 and and CC cord-335975-m6lkrehi 996 28 1-month 1-month CD cord-335975-m6lkrehi 996 29 mortality mortality NN cord-335975-m6lkrehi 997 1 ( ( -LRB- cord-335975-m6lkrehi 997 2 Introduction introduction NN cord-335975-m6lkrehi 997 3 : : : cord-335975-m6lkrehi 997 4 Post post JJ cord-335975-m6lkrehi 997 5 - - JJ cord-335975-m6lkrehi 997 6 intensive intensive JJ cord-335975-m6lkrehi 997 7 care care NN cord-335975-m6lkrehi 997 8 syndrome syndrome NN cord-335975-m6lkrehi 997 9 ( ( -LRB- cord-335975-m6lkrehi 997 10 PICS PICS NNP cord-335975-m6lkrehi 997 11 ) ) -RRB- cord-335975-m6lkrehi 997 12 has have VBZ cord-335975-m6lkrehi 997 13 been be VBN cord-335975-m6lkrehi 997 14 recently recently RB cord-335975-m6lkrehi 997 15 described describe VBN cord-335975-m6lkrehi 997 16 as as IN cord-335975-m6lkrehi 997 17 a a DT cord-335975-m6lkrehi 997 18 combination combination NN cord-335975-m6lkrehi 997 19 of of IN cord-335975-m6lkrehi 997 20 physical physical JJ cord-335975-m6lkrehi 997 21 , , , cord-335975-m6lkrehi 997 22 cognitive cognitive JJ cord-335975-m6lkrehi 997 23 and and CC cord-335975-m6lkrehi 997 24 mental mental JJ cord-335975-m6lkrehi 997 25 impairments impairment NNS cord-335975-m6lkrehi 997 26 appearing appear VBG cord-335975-m6lkrehi 997 27 during during IN cord-335975-m6lkrehi 997 28 a a DT cord-335975-m6lkrehi 997 29 stay stay NN cord-335975-m6lkrehi 997 30 in in IN cord-335975-m6lkrehi 997 31 an an DT cord-335975-m6lkrehi 997 32 intensive intensive JJ cord-335975-m6lkrehi 997 33 care care NN cord-335975-m6lkrehi 997 34 unit unit NN cord-335975-m6lkrehi 997 35 ( ( -LRB- cord-335975-m6lkrehi 997 36 ICU ICU NNP cord-335975-m6lkrehi 997 37 ) ) -RRB- cord-335975-m6lkrehi 997 38 . . . cord-335975-m6lkrehi 998 1 The the DT cord-335975-m6lkrehi 998 2 prevention prevention NN cord-335975-m6lkrehi 998 3 and and CC cord-335975-m6lkrehi 998 4 detection detection NN cord-335975-m6lkrehi 998 5 of of IN cord-335975-m6lkrehi 998 6 PICS PICS NNPS cord-335975-m6lkrehi 998 7 require require VBP cord-335975-m6lkrehi 998 8 the the DT cord-335975-m6lkrehi 998 9 participation participation NN cord-335975-m6lkrehi 998 10 of of IN cord-335975-m6lkrehi 998 11 each each DT cord-335975-m6lkrehi 998 12 category category NN cord-335975-m6lkrehi 998 13 of of IN cord-335975-m6lkrehi 998 14 healthcare healthcare NN cord-335975-m6lkrehi 998 15 workers worker NNS cord-335975-m6lkrehi 998 16 . . . cord-335975-m6lkrehi 999 1 However however RB cord-335975-m6lkrehi 999 2 , , , cord-335975-m6lkrehi 999 3 the the DT cord-335975-m6lkrehi 999 4 level level NN cord-335975-m6lkrehi 999 5 of of IN cord-335975-m6lkrehi 999 6 knowledge knowledge NN cord-335975-m6lkrehi 999 7 is be VBZ cord-335975-m6lkrehi 999 8 unknown unknown JJ cord-335975-m6lkrehi 999 9 . . . cord-335975-m6lkrehi 1000 1 We -PRON- PRP cord-335975-m6lkrehi 1000 2 sought seek VBD cord-335975-m6lkrehi 1000 3 to to TO cord-335975-m6lkrehi 1000 4 assess assess VB cord-335975-m6lkrehi 1000 5 the the DT cord-335975-m6lkrehi 1000 6 awareness awareness NN cord-335975-m6lkrehi 1000 7 among among IN cord-335975-m6lkrehi 1000 8 our -PRON- PRP$ cord-335975-m6lkrehi 1000 9 ICU ICU NNP cord-335975-m6lkrehi 1000 10 staff staff NN cord-335975-m6lkrehi 1000 11 in in IN cord-335975-m6lkrehi 1000 12 preparation preparation NN cord-335975-m6lkrehi 1000 13 for for IN cord-335975-m6lkrehi 1000 14 a a DT cord-335975-m6lkrehi 1000 15 follow follow VB cord-335975-m6lkrehi 1000 16 - - HYPH cord-335975-m6lkrehi 1000 17 up up NN cord-335975-m6lkrehi 1000 18 consultation consultation NN cord-335975-m6lkrehi 1000 19 . . . cord-335975-m6lkrehi 1001 1 The the DT cord-335975-m6lkrehi 1001 2 study study NN cord-335975-m6lkrehi 1001 3 used use VBD cord-335975-m6lkrehi 1001 4 a a DT cord-335975-m6lkrehi 1001 5 short short JJ cord-335975-m6lkrehi 1001 6 multiple multiple JJ cord-335975-m6lkrehi 1001 7 - - HYPH cord-335975-m6lkrehi 1001 8 choice choice NN cord-335975-m6lkrehi 1001 9 survey survey NN cord-335975-m6lkrehi 1001 10 filled fill VBN cord-335975-m6lkrehi 1001 11 on on IN cord-335975-m6lkrehi 1001 12 a a DT cord-335975-m6lkrehi 1001 13 voluntary voluntary JJ cord-335975-m6lkrehi 1001 14 basis basis NN cord-335975-m6lkrehi 1001 15 . . . cord-335975-m6lkrehi 1002 1 All all DT cord-335975-m6lkrehi 1002 2 members member NNS cord-335975-m6lkrehi 1002 3 of of IN cord-335975-m6lkrehi 1002 4 the the DT cord-335975-m6lkrehi 1002 5 staff staff NN cord-335975-m6lkrehi 1002 6 were be VBD cord-335975-m6lkrehi 1002 7 asked ask VBN cord-335975-m6lkrehi 1002 8 to to TO cord-335975-m6lkrehi 1002 9 fill fill VB cord-335975-m6lkrehi 1002 10 the the DT cord-335975-m6lkrehi 1002 11 questionnaire questionnaire NN cord-335975-m6lkrehi 1002 12 over over IN cord-335975-m6lkrehi 1002 13 a a DT cord-335975-m6lkrehi 1002 14 one one CD cord-335975-m6lkrehi 1002 15 - - HYPH cord-335975-m6lkrehi 1002 16 week week NN cord-335975-m6lkrehi 1002 17 period period NN cord-335975-m6lkrehi 1002 18 . . . cord-335975-m6lkrehi 1003 1 The the DT cord-335975-m6lkrehi 1003 2 assessment assessment NN cord-335975-m6lkrehi 1003 3 was be VBD cord-335975-m6lkrehi 1003 4 composed compose VBN cord-335975-m6lkrehi 1003 5 by by IN cord-335975-m6lkrehi 1003 6 seven seven CD cord-335975-m6lkrehi 1003 7 structured structured JJ cord-335975-m6lkrehi 1003 8 questions question NNS cord-335975-m6lkrehi 1003 9 which which WDT cord-335975-m6lkrehi 1003 10 aimed aim VBD cord-335975-m6lkrehi 1003 11 measure measure VB cord-335975-m6lkrehi 1003 12 basic basic JJ cord-335975-m6lkrehi 1003 13 knowledge knowledge NN cord-335975-m6lkrehi 1003 14 of of IN cord-335975-m6lkrehi 1003 15 post post JJ cord-335975-m6lkrehi 1003 16 - - JJ cord-335975-m6lkrehi 1003 17 intensive intensive JJ cord-335975-m6lkrehi 1003 18 care care NN cord-335975-m6lkrehi 1003 19 syndrome syndrome NN cord-335975-m6lkrehi 1003 20 and and CC cord-335975-m6lkrehi 1003 21 general general JJ cord-335975-m6lkrehi 1003 22 strategies strategy NNS cord-335975-m6lkrehi 1003 23 to to TO cord-335975-m6lkrehi 1003 24 diagnose diagnose VB cord-335975-m6lkrehi 1003 25 that that DT cord-335975-m6lkrehi 1003 26 syndrome syndrome NN cord-335975-m6lkrehi 1003 27 and and CC cord-335975-m6lkrehi 1003 28 the the DT cord-335975-m6lkrehi 1003 29 tests test NNS cord-335975-m6lkrehi 1003 30 used use VBD cord-335975-m6lkrehi 1003 31 . . . cord-335975-m6lkrehi 1004 1 Results result NNS cord-335975-m6lkrehi 1004 2 : : : cord-335975-m6lkrehi 1005 1 Fifth fifth JJ cord-335975-m6lkrehi 1005 2 five five CD cord-335975-m6lkrehi 1005 3 workers worker NNS cord-335975-m6lkrehi 1005 4 ( ( -LRB- cord-335975-m6lkrehi 1005 5 30 30 CD cord-335975-m6lkrehi 1005 6 % % NN cord-335975-m6lkrehi 1005 7 of of IN cord-335975-m6lkrehi 1005 8 the the DT cord-335975-m6lkrehi 1005 9 staff staff NN cord-335975-m6lkrehi 1005 10 ) ) -RRB- cord-335975-m6lkrehi 1005 11 of of IN cord-335975-m6lkrehi 1005 12 the the DT cord-335975-m6lkrehi 1005 13 department department NN cord-335975-m6lkrehi 1005 14 of of IN cord-335975-m6lkrehi 1005 15 intensive intensive JJ cord-335975-m6lkrehi 1005 16 care care NN cord-335975-m6lkrehi 1005 17 answered answer VBD cord-335975-m6lkrehi 1005 18 the the DT cord-335975-m6lkrehi 1005 19 questionnaires questionnaire NNS cord-335975-m6lkrehi 1005 20 ( ( -LRB- cord-335975-m6lkrehi 1005 21 67 67 CD cord-335975-m6lkrehi 1005 22 % % NN cord-335975-m6lkrehi 1005 23 nurses nurse NNS cord-335975-m6lkrehi 1005 24 , , , cord-335975-m6lkrehi 1005 25 7 7 CD cord-335975-m6lkrehi 1005 26 % % NN cord-335975-m6lkrehi 1005 27 physiotherapists physiotherapist NNS cord-335975-m6lkrehi 1005 28 , , , cord-335975-m6lkrehi 1005 29 20 20 CD cord-335975-m6lkrehi 1005 30 % % NN cord-335975-m6lkrehi 1005 31 physicians physician NNS cord-335975-m6lkrehi 1005 32 ) ) -RRB- cord-335975-m6lkrehi 1005 33 . . . cord-335975-m6lkrehi 1006 1 The the DT cord-335975-m6lkrehi 1006 2 estimated estimate VBN cord-335975-m6lkrehi 1006 3 ranges range NNS cord-335975-m6lkrehi 1006 4 of of IN cord-335975-m6lkrehi 1006 5 prevalence prevalence NN cord-335975-m6lkrehi 1006 6 of of IN cord-335975-m6lkrehi 1006 7 psychological psychological JJ cord-335975-m6lkrehi 1006 8 problems problem NNS cord-335975-m6lkrehi 1006 9 were be VBD cord-335975-m6lkrehi 1006 10 very very RB cord-335975-m6lkrehi 1006 11 low low JJ cord-335975-m6lkrehi 1006 12 ( ( -LRB- cord-335975-m6lkrehi 1006 13 0 0 CD cord-335975-m6lkrehi 1006 14 - - SYM cord-335975-m6lkrehi 1006 15 25 25 CD cord-335975-m6lkrehi 1006 16 % % NN cord-335975-m6lkrehi 1006 17 ) ) -RRB- cord-335975-m6lkrehi 1006 18 for for IN cord-335975-m6lkrehi 1006 19 3.63 3.63 CD cord-335975-m6lkrehi 1006 20 % % NN cord-335975-m6lkrehi 1006 21 , , , cord-335975-m6lkrehi 1006 22 low low JJ cord-335975-m6lkrehi 1006 23 ( ( -LRB- cord-335975-m6lkrehi 1006 24 Introduction introduction NN cord-335975-m6lkrehi 1006 25 : : : cord-335975-m6lkrehi 1006 26 Drafting draft VBG cord-335975-m6lkrehi 1006 27 a a DT cord-335975-m6lkrehi 1006 28 death death NN cord-335975-m6lkrehi 1006 29 certificate certificate NN cord-335975-m6lkrehi 1006 30 ( ( -LRB- cord-335975-m6lkrehi 1006 31 DC DC NNP cord-335975-m6lkrehi 1006 32 ) ) -RRB- cord-335975-m6lkrehi 1006 33 is be VBZ cord-335975-m6lkrehi 1006 34 a a DT cord-335975-m6lkrehi 1006 35 procedure procedure NN cord-335975-m6lkrehi 1006 36 considered consider VBN cord-335975-m6lkrehi 1006 37 as as IN cord-335975-m6lkrehi 1006 38 a a DT cord-335975-m6lkrehi 1006 39 part part NN cord-335975-m6lkrehi 1006 40 of of IN cord-335975-m6lkrehi 1006 41 doctor doctor NN cord-335975-m6lkrehi 1006 42 's 's POS cord-335975-m6lkrehi 1006 43 daily daily JJ cord-335975-m6lkrehi 1006 44 practice practice NN cord-335975-m6lkrehi 1006 45 , , , cord-335975-m6lkrehi 1006 46 especially especially RB cord-335975-m6lkrehi 1006 47 in in IN cord-335975-m6lkrehi 1006 48 emergency emergency NN cord-335975-m6lkrehi 1006 49 and and CC cord-335975-m6lkrehi 1006 50 intensive intensive JJ cord-335975-m6lkrehi 1006 51 care care NN cord-335975-m6lkrehi 1006 52 departments department NNS cord-335975-m6lkrehi 1006 53 . . . cord-335975-m6lkrehi 1007 1 This this DT cord-335975-m6lkrehi 1007 2 certificate certificate NN cord-335975-m6lkrehi 1007 3 represents represent VBZ cord-335975-m6lkrehi 1007 4 a a DT cord-335975-m6lkrehi 1007 5 civil civil JJ cord-335975-m6lkrehi 1007 6 , , , cord-335975-m6lkrehi 1007 7 social social JJ cord-335975-m6lkrehi 1007 8 , , , cord-335975-m6lkrehi 1007 9 epidemiological epidemiological JJ cord-335975-m6lkrehi 1007 10 and and CC cord-335975-m6lkrehi 1007 11 medico medico JJ cord-335975-m6lkrehi 1007 12 - - HYPH cord-335975-m6lkrehi 1007 13 legal legal JJ cord-335975-m6lkrehi 1007 14 act act NN cord-335975-m6lkrehi 1007 15 . . . cord-335975-m6lkrehi 1008 1 It -PRON- PRP cord-335975-m6lkrehi 1008 2 can can MD cord-335975-m6lkrehi 1008 3 engage engage VB cord-335975-m6lkrehi 1008 4 the the DT cord-335975-m6lkrehi 1008 5 liability liability NN cord-335975-m6lkrehi 1008 6 of of IN cord-335975-m6lkrehi 1008 7 the the DT cord-335975-m6lkrehi 1008 8 certifying certify VBG cord-335975-m6lkrehi 1008 9 doctor doctor NN cord-335975-m6lkrehi 1008 10 . . . cord-335975-m6lkrehi 1009 1 The the DT cord-335975-m6lkrehi 1009 2 objectives objective NNS cord-335975-m6lkrehi 1009 3 of of IN cord-335975-m6lkrehi 1009 4 our -PRON- PRP$ cord-335975-m6lkrehi 1009 5 study study NN cord-335975-m6lkrehi 1009 6 were be VBD cord-335975-m6lkrehi 1009 7 to to TO cord-335975-m6lkrehi 1009 8 examine examine VB cord-335975-m6lkrehi 1009 9 the the DT cord-335975-m6lkrehi 1009 10 content content NN cord-335975-m6lkrehi 1009 11 of of IN cord-335975-m6lkrehi 1009 12 DC DC NNP cord-335975-m6lkrehi 1009 13 drafted draft VBN cord-335975-m6lkrehi 1009 14 in in IN cord-335975-m6lkrehi 1009 15 emergency emergency NN cord-335975-m6lkrehi 1009 16 and and CC cord-335975-m6lkrehi 1009 17 intensive intensive JJ cord-335975-m6lkrehi 1009 18 care care NN cord-335975-m6lkrehi 1009 19 departments department NNS cord-335975-m6lkrehi 1009 20 , , , cord-335975-m6lkrehi 1009 21 assess assess VB cord-335975-m6lkrehi 1009 22 the the DT cord-335975-m6lkrehi 1009 23 quality quality NN cord-335975-m6lkrehi 1009 24 of of IN cord-335975-m6lkrehi 1009 25 writing writing NN cord-335975-m6lkrehi 1009 26 , , , cord-335975-m6lkrehi 1009 27 and and CC cord-335975-m6lkrehi 1009 28 analyze analyze VB cord-335975-m6lkrehi 1009 29 drafting drafting NN cord-335975-m6lkrehi 1009 30 errors error NNS cord-335975-m6lkrehi 1009 31 . . . cord-335975-m6lkrehi 1010 1 Patients patient NNS cord-335975-m6lkrehi 1010 2 and and CC cord-335975-m6lkrehi 1010 3 methods method NNS cord-335975-m6lkrehi 1010 4 : : : cord-335975-m6lkrehi 1010 5 A a DT cord-335975-m6lkrehi 1010 6 prospective prospective JJ cord-335975-m6lkrehi 1010 7 study study NN cord-335975-m6lkrehi 1010 8 extended extend VBN cord-335975-m6lkrehi 1010 9 over over IN cord-335975-m6lkrehi 1010 10 a a DT cord-335975-m6lkrehi 1010 11 period period NN cord-335975-m6lkrehi 1010 12 of of IN cord-335975-m6lkrehi 1010 13 12 12 CD cord-335975-m6lkrehi 1010 14 months month NNS cord-335975-m6lkrehi 1010 15 from from IN cord-335975-m6lkrehi 1010 16 January January NNP cord-335975-m6lkrehi 1010 17 to to IN cord-335975-m6lkrehi 1010 18 December December NNP cord-335975-m6lkrehi 1010 19 2015 2015 CD cord-335975-m6lkrehi 1010 20 , , , cord-335975-m6lkrehi 1010 21 including include VBG cord-335975-m6lkrehi 1010 22 all all DT cord-335975-m6lkrehi 1010 23 DC DC NNP cord-335975-m6lkrehi 1010 24 emanating emanate VBG cord-335975-m6lkrehi 1010 25 from from IN cord-335975-m6lkrehi 1010 26 emergency emergency NN cord-335975-m6lkrehi 1010 27 and and CC cord-335975-m6lkrehi 1010 28 intensive intensive JJ cord-335975-m6lkrehi 1010 29 care care NN cord-335975-m6lkrehi 1010 30 departments department NNS cord-335975-m6lkrehi 1010 31 and and CC cord-335975-m6lkrehi 1010 32 received receive VBD cord-335975-m6lkrehi 1010 33 in in IN cord-335975-m6lkrehi 1010 34 the the DT cord-335975-m6lkrehi 1010 35 forensic forensic JJ cord-335975-m6lkrehi 1010 36 department department NN cord-335975-m6lkrehi 1010 37 of of IN cord-335975-m6lkrehi 1010 38 Habib Habib NNP cord-335975-m6lkrehi 1010 39 Bourguiba Bourguiba NNP cord-335975-m6lkrehi 1010 40 hospital hospital NN cord-335975-m6lkrehi 1010 41 in in IN cord-335975-m6lkrehi 1010 42 Sfax Sfax NNP cord-335975-m6lkrehi 1010 43 . . . cord-335975-m6lkrehi 1011 1 Results result NNS cord-335975-m6lkrehi 1011 2 : : : cord-335975-m6lkrehi 1012 1 During during IN cord-335975-m6lkrehi 1012 2 the the DT cord-335975-m6lkrehi 1012 3 study study NN cord-335975-m6lkrehi 1012 4 period period NN cord-335975-m6lkrehi 1012 5 , , , cord-335975-m6lkrehi 1012 6 120 120 CD cord-335975-m6lkrehi 1012 7 DC DC NNP cord-335975-m6lkrehi 1012 8 meeting meet VBG cord-335975-m6lkrehi 1012 9 the the DT cord-335975-m6lkrehi 1012 10 inclusion inclusion NN cord-335975-m6lkrehi 1012 11 criteria criterion NNS cord-335975-m6lkrehi 1012 12 were be VBD cord-335975-m6lkrehi 1012 13 collected collect VBN cord-335975-m6lkrehi 1012 14 . . . cord-335975-m6lkrehi 1013 1 Although although IN cord-335975-m6lkrehi 1013 2 confidential confidential JJ cord-335975-m6lkrehi 1013 3 , , , cord-335975-m6lkrehi 1013 4 the the DT cord-335975-m6lkrehi 1013 5 medical medical JJ cord-335975-m6lkrehi 1013 6 part part NN cord-335975-m6lkrehi 1013 7 of of IN cord-335975-m6lkrehi 1013 8 the the DT cord-335975-m6lkrehi 1013 9 DC DC NNP cord-335975-m6lkrehi 1013 10 was be VBD cord-335975-m6lkrehi 1013 11 sealed seal VBN cord-335975-m6lkrehi 1013 12 by by IN cord-335975-m6lkrehi 1013 13 the the DT cord-335975-m6lkrehi 1013 14 doctor doctor NN cord-335975-m6lkrehi 1013 15 in in IN cord-335975-m6lkrehi 1013 16 onlyone onlyone NNP cord-335975-m6lkrehi 1013 17 third third NN cord-335975-m6lkrehi 1013 18 of of IN cord-335975-m6lkrehi 1013 19 cases case NNS cord-335975-m6lkrehi 1013 20 . . . cord-335975-m6lkrehi 1014 1 In in IN cord-335975-m6lkrehi 1014 2 the the DT cord-335975-m6lkrehi 1014 3 administrative administrative JJ cord-335975-m6lkrehi 1014 4 section section NN cord-335975-m6lkrehi 1014 5 , , , cord-335975-m6lkrehi 1014 6 nine nine CD cord-335975-m6lkrehi 1014 7 socio socio JJ cord-335975-m6lkrehi 1014 8 - - HYPH cord-335975-m6lkrehi 1014 9 demographic demographic JJ cord-335975-m6lkrehi 1014 10 parameters parameter NNS cord-335975-m6lkrehi 1014 11 were be VBD cord-335975-m6lkrehi 1014 12 studied study VBN cord-335975-m6lkrehi 1014 13 . . . cord-335975-m6lkrehi 1015 1 In in IN cord-335975-m6lkrehi 1015 2 10 10 CD cord-335975-m6lkrehi 1015 3 % % NN cord-335975-m6lkrehi 1015 4 of of IN cord-335975-m6lkrehi 1015 5 the the DT cord-335975-m6lkrehi 1015 6 cases case NNS cord-335975-m6lkrehi 1015 7 , , , cord-335975-m6lkrehi 1015 8 less less JJR cord-335975-m6lkrehi 1015 9 than than IN cord-335975-m6lkrehi 1015 10 four four CD cord-335975-m6lkrehi 1015 11 of of IN cord-335975-m6lkrehi 1015 12 the the DT cord-335975-m6lkrehi 1015 13 nine nine CD cord-335975-m6lkrehi 1015 14 criteria criterion NNS cord-335975-m6lkrehi 1015 15 were be VBD cord-335975-m6lkrehi 1015 16 found find VBN cord-335975-m6lkrehi 1015 17 . . . cord-335975-m6lkrehi 1016 1 In in IN cord-335975-m6lkrehi 1016 2 the the DT cord-335975-m6lkrehi 1016 3 section section NN cord-335975-m6lkrehi 1016 4 concerning concern VBG cord-335975-m6lkrehi 1016 5 the the DT cord-335975-m6lkrehi 1016 6 certifying certify VBG cord-335975-m6lkrehi 1016 7 doctor doctor NN cord-335975-m6lkrehi 1016 8 data datum NNS cord-335975-m6lkrehi 1016 9 , , , cord-335975-m6lkrehi 1016 10 7 7 CD cord-335975-m6lkrehi 1016 11 parameters parameter NNS cord-335975-m6lkrehi 1016 12 were be VBD cord-335975-m6lkrehi 1016 13 screened screen VBN cord-335975-m6lkrehi 1016 14 . . . cord-335975-m6lkrehi 1017 1 67.1 67.1 CD cord-335975-m6lkrehi 1017 2 % % NN cord-335975-m6lkrehi 1017 3 of of IN cord-335975-m6lkrehi 1017 4 the the DT cord-335975-m6lkrehi 1017 5 certifying certify VBG cord-335975-m6lkrehi 1017 6 doctors doctor NNS cord-335975-m6lkrehi 1017 7 met meet VBD cord-335975-m6lkrehi 1017 8 at at IN cord-335975-m6lkrehi 1017 9 least least JJS cord-335975-m6lkrehi 1017 10 six six CD cord-335975-m6lkrehi 1017 11 criteria criterion NNS cord-335975-m6lkrehi 1017 12 . . . cord-335975-m6lkrehi 1018 1 The the DT cord-335975-m6lkrehi 1018 2 most most RBS cord-335975-m6lkrehi 1018 3 frequently frequently RB cord-335975-m6lkrehi 1018 4 missing missing JJ cord-335975-m6lkrehi 1018 5 parameter parameter NN cord-335975-m6lkrehi 1018 6 in in IN cord-335975-m6lkrehi 1018 7 this this DT cord-335975-m6lkrehi 1018 8 section section NN cord-335975-m6lkrehi 1018 9 was be VBD cord-335975-m6lkrehi 1018 10 the the DT cord-335975-m6lkrehi 1018 11 identity identity NN cord-335975-m6lkrehi 1018 12 of of IN cord-335975-m6lkrehi 1018 13 the the DT cord-335975-m6lkrehi 1018 14 person person NN cord-335975-m6lkrehi 1018 15 to to TO cord-335975-m6lkrehi 1018 16 whom whom WP cord-335975-m6lkrehi 1018 17 the the DT cord-335975-m6lkrehi 1018 18 certificate certificate NN cord-335975-m6lkrehi 1018 19 was be VBD cord-335975-m6lkrehi 1018 20 issued issue VBN cord-335975-m6lkrehi 1018 21 . . . cord-335975-m6lkrehi 1019 1 The the DT cord-335975-m6lkrehi 1019 2 identity identity NN cord-335975-m6lkrehi 1019 3 of of IN cord-335975-m6lkrehi 1019 4 the the DT cord-335975-m6lkrehi 1019 5 doctor doctor NN cord-335975-m6lkrehi 1019 6 was be VBD cord-335975-m6lkrehi 1019 7 not not RB cord-335975-m6lkrehi 1019 8 mentioned mention VBN cord-335975-m6lkrehi 1019 9 in in IN cord-335975-m6lkrehi 1019 10 10 10 CD cord-335975-m6lkrehi 1019 11 % % NN cord-335975-m6lkrehi 1019 12 of of IN cord-335975-m6lkrehi 1019 13 the the DT cord-335975-m6lkrehi 1019 14 cases case NNS cord-335975-m6lkrehi 1019 15 . . . cord-335975-m6lkrehi 1020 1 Forensic forensic JJ cord-335975-m6lkrehi 1020 2 data datum NNS cord-335975-m6lkrehi 1020 3 ( ( -LRB- cord-335975-m6lkrehi 1020 4 4 4 CD cord-335975-m6lkrehi 1020 5 items item NNS cord-335975-m6lkrehi 1020 6 ) ) -RRB- cord-335975-m6lkrehi 1020 7 was be VBD cord-335975-m6lkrehi 1020 8 complete complete JJ cord-335975-m6lkrehi 1020 9 in in IN cord-335975-m6lkrehi 1020 10 over over IN cord-335975-m6lkrehi 1020 11 three three CD cord-335975-m6lkrehi 1020 12 quarters quarter NNS cord-335975-m6lkrehi 1020 13 of of IN cord-335975-m6lkrehi 1020 14 the the DT cord-335975-m6lkrehi 1020 15 certificates certificate NNS cord-335975-m6lkrehi 1020 16 . . . cord-335975-m6lkrehi 1021 1 Nevertheless nevertheless RB cord-335975-m6lkrehi 1021 2 , , , cord-335975-m6lkrehi 1021 3 in in IN cord-335975-m6lkrehi 1021 4 26.7 26.7 CD cord-335975-m6lkrehi 1021 5 % % NN cord-335975-m6lkrehi 1021 6 of of IN cord-335975-m6lkrehi 1021 7 cases case NNS cord-335975-m6lkrehi 1021 8 , , , cord-335975-m6lkrehi 1021 9 the the DT cord-335975-m6lkrehi 1021 10 medicolegal medicolegal JJ cord-335975-m6lkrehi 1021 11 obstacle obstacle NN cord-335975-m6lkrehi 1021 12 to to IN cord-335975-m6lkrehi 1021 13 burial burial JJ cord-335975-m6lkrehi 1021 14 box box NN cord-335975-m6lkrehi 1021 15 was be VBD cord-335975-m6lkrehi 1021 16 left leave VBN cord-335975-m6lkrehi 1021 17 empty empty JJ cord-335975-m6lkrehi 1021 18 ( ( -LRB- cord-335975-m6lkrehi 1021 19 8.3 8.3 CD cord-335975-m6lkrehi 1021 20 % % NN cord-335975-m6lkrehi 1021 21 ) ) -RRB- cord-335975-m6lkrehi 1021 22 or or CC cord-335975-m6lkrehi 1021 23 not not RB cord-335975-m6lkrehi 1021 24 ticked tick VBN cord-335975-m6lkrehi 1021 25 even even RB cord-335975-m6lkrehi 1021 26 if if IN cord-335975-m6lkrehi 1021 27 judicial judicial JJ cord-335975-m6lkrehi 1021 28 investigation investigation NN cord-335975-m6lkrehi 1021 29 was be VBD cord-335975-m6lkrehi 1021 30 required require VBN cord-335975-m6lkrehi 1021 31 ( ( -LRB- cord-335975-m6lkrehi 1021 32 18.3 18.3 CD cord-335975-m6lkrehi 1021 33 % % NN cord-335975-m6lkrehi 1021 34 ) ) -RRB- cord-335975-m6lkrehi 1021 35 . . . cord-335975-m6lkrehi 1022 1 The the DT cord-335975-m6lkrehi 1022 2 section section NN cord-335975-m6lkrehi 1022 3 on on IN cord-335975-m6lkrehi 1022 4 causes cause NNS cord-335975-m6lkrehi 1022 5 of of IN cord-335975-m6lkrehi 1022 6 death death NN cord-335975-m6lkrehi 1022 7 was be VBD cord-335975-m6lkrehi 1022 8 the the DT cord-335975-m6lkrehi 1022 9 source source NN cord-335975-m6lkrehi 1022 10 of of IN cord-335975-m6lkrehi 1022 11 almost almost RB cord-335975-m6lkrehi 1022 12 all all DT cord-335975-m6lkrehi 1022 13 of of IN cord-335975-m6lkrehi 1022 14 the the DT cord-335975-m6lkrehi 1022 15 drafting drafting NN cord-335975-m6lkrehi 1022 16 errors error NNS cord-335975-m6lkrehi 1022 17 . . . cord-335975-m6lkrehi 1023 1 We -PRON- PRP cord-335975-m6lkrehi 1023 2 have have VBP cord-335975-m6lkrehi 1023 3 classified classify VBN cord-335975-m6lkrehi 1023 4 these these DT cord-335975-m6lkrehi 1023 5 errors error NNS cord-335975-m6lkrehi 1023 6 into into IN cord-335975-m6lkrehi 1023 7 six six CD cord-335975-m6lkrehi 1023 8 major major JJ cord-335975-m6lkrehi 1023 9 ones one NNS cord-335975-m6lkrehi 1023 10 , , , cord-335975-m6lkrehi 1023 11 according accord VBG cord-335975-m6lkrehi 1023 12 the the DT cord-335975-m6lkrehi 1023 13 classifications classification NNS cord-335975-m6lkrehi 1023 14 reported report VBN cord-335975-m6lkrehi 1023 15 in in IN cord-335975-m6lkrehi 1023 16 the the DT cord-335975-m6lkrehi 1023 17 literature literature NN cord-335975-m6lkrehi 1023 18 . . . cord-335975-m6lkrehi 1024 1 The the DT cord-335975-m6lkrehi 1024 2 percentage percentage NN cord-335975-m6lkrehi 1024 3 of of IN cord-335975-m6lkrehi 1024 4 certificate certificate NN cord-335975-m6lkrehi 1024 5 without without IN cord-335975-m6lkrehi 1024 6 faults fault NNS cord-335975-m6lkrehi 1024 7 was be VBD cord-335975-m6lkrehi 1024 8 13 13 CD cord-335975-m6lkrehi 1024 9 % % NN cord-335975-m6lkrehi 1024 10 . . . cord-335975-m6lkrehi 1025 1 The the DT cord-335975-m6lkrehi 1025 2 most most RBS cord-335975-m6lkrehi 1025 3 common common JJ cord-335975-m6lkrehi 1025 4 major major JJ cord-335975-m6lkrehi 1025 5 error error NN cord-335975-m6lkrehi 1025 6 was be VBD cord-335975-m6lkrehi 1025 7 insufficient insufficient JJ cord-335975-m6lkrehi 1025 8 cause cause NN cord-335975-m6lkrehi 1025 9 of of IN cord-335975-m6lkrehi 1025 10 death death NN cord-335975-m6lkrehi 1025 11 found find VBN cord-335975-m6lkrehi 1025 12 in in IN cord-335975-m6lkrehi 1025 13 40.4 40.4 CD cord-335975-m6lkrehi 1025 14 % % NN cord-335975-m6lkrehi 1025 15 of of IN cord-335975-m6lkrehi 1025 16 cases case NNS cord-335975-m6lkrehi 1025 17 followed follow VBN cord-335975-m6lkrehi 1025 18 by by IN cord-335975-m6lkrehi 1025 19 incorrect incorrect JJ cord-335975-m6lkrehi 1025 20 sequence sequence NN cord-335975-m6lkrehi 1025 21 of of IN cord-335975-m6lkrehi 1025 22 causes cause NNS cord-335975-m6lkrehi 1025 23 of of IN cord-335975-m6lkrehi 1025 24 death death NN cord-335975-m6lkrehi 1025 25 ( ( -LRB- cord-335975-m6lkrehi 1025 26 28.8 28.8 CD cord-335975-m6lkrehi 1025 27 % % NN cord-335975-m6lkrehi 1025 28 ) ) -RRB- cord-335975-m6lkrehi 1025 29 , , , cord-335975-m6lkrehi 1025 30 medicolegal medicolegal JJ cord-335975-m6lkrehi 1025 31 obstacle obstacle NN cord-335975-m6lkrehi 1025 32 to to IN cord-335975-m6lkrehi 1025 33 burial burial NN cord-335975-m6lkrehi 1025 34 not not RB cord-335975-m6lkrehi 1025 35 ticked tick VBN cord-335975-m6lkrehi 1025 36 although although IN cord-335975-m6lkrehi 1025 37 required require VBN cord-335975-m6lkrehi 1025 38 ( ( -LRB- cord-335975-m6lkrehi 1025 39 26.6 26.6 CD cord-335975-m6lkrehi 1025 40 % % NN cord-335975-m6lkrehi 1025 41 ) ) -RRB- cord-335975-m6lkrehi 1025 42 , , , cord-335975-m6lkrehi 1025 43 several several JJ cord-335975-m6lkrehi 1025 44 causes cause NNS cord-335975-m6lkrehi 1025 45 of of IN cord-335975-m6lkrehi 1025 46 death death NN cord-335975-m6lkrehi 1025 47 mentioned mention VBN cord-335975-m6lkrehi 1025 48 simultaneously simultaneously RB cord-335975-m6lkrehi 1025 49 ( ( -LRB- cord-335975-m6lkrehi 1025 50 16.7 16.7 CD cord-335975-m6lkrehi 1025 51 % % NN cord-335975-m6lkrehi 1025 52 ) ) -RRB- cord-335975-m6lkrehi 1025 53 , , , cord-335975-m6lkrehi 1025 54 unacceptable unacceptable JJ cord-335975-m6lkrehi 1025 55 cause cause NN cord-335975-m6lkrehi 1025 56 of of IN cord-335975-m6lkrehi 1025 57 death death NN cord-335975-m6lkrehi 1025 58 ( ( -LRB- cord-335975-m6lkrehi 1025 59 10.8 10.8 CD cord-335975-m6lkrehi 1025 60 % % NN cord-335975-m6lkrehi 1025 61 ) ) -RRB- cord-335975-m6lkrehi 1025 62 and and CC cord-335975-m6lkrehi 1025 63 mechanism mechanism NN cord-335975-m6lkrehi 1025 64 of of IN cord-335975-m6lkrehi 1025 65 death death NN cord-335975-m6lkrehi 1025 66 mentioned mention VBN cord-335975-m6lkrehi 1025 67 instead instead RB cord-335975-m6lkrehi 1025 68 of of IN cord-335975-m6lkrehi 1025 69 the the DT cord-335975-m6lkrehi 1025 70 cause cause NN cord-335975-m6lkrehi 1025 71 of of IN cord-335975-m6lkrehi 1025 72 death death NN cord-335975-m6lkrehi 1025 73 ( ( -LRB- cord-335975-m6lkrehi 1025 74 5.8 5.8 CD cord-335975-m6lkrehi 1025 75 % % NN cord-335975-m6lkrehi 1025 76 ) ) -RRB- cord-335975-m6lkrehi 1025 77 . . . cord-335975-m6lkrehi 1026 1 Our -PRON- PRP$ cord-335975-m6lkrehi 1026 2 study study NN cord-335975-m6lkrehi 1026 3 showed show VBD cord-335975-m6lkrehi 1026 4 that that IN cord-335975-m6lkrehi 1026 5 the the DT cord-335975-m6lkrehi 1026 6 quality quality NN cord-335975-m6lkrehi 1026 7 of of IN cord-335975-m6lkrehi 1026 8 drafting drafting NN cord-335975-m6lkrehi 1026 9 of of IN cord-335975-m6lkrehi 1026 10 DC DC NNP cord-335975-m6lkrehi 1026 11 suffered suffer VBD cord-335975-m6lkrehi 1026 12 from from IN cord-335975-m6lkrehi 1026 13 several several JJ cord-335975-m6lkrehi 1026 14 insufficiencies insufficiency NNS cord-335975-m6lkrehi 1026 15 , , , cord-335975-m6lkrehi 1026 16 which which WDT cord-335975-m6lkrehi 1026 17 encourages encourage VBZ cord-335975-m6lkrehi 1026 18 us -PRON- PRP cord-335975-m6lkrehi 1026 19 to to TO cord-335975-m6lkrehi 1026 20 provide provide VB cord-335975-m6lkrehi 1026 21 more more JJR cord-335975-m6lkrehi 1026 22 effort effort NN cord-335975-m6lkrehi 1026 23 in in IN cord-335975-m6lkrehi 1026 24 training train VBG cord-335975-m6lkrehi 1026 25 doctors doctor NNS cord-335975-m6lkrehi 1026 26 and and CC cord-335975-m6lkrehi 1026 27 to to TO cord-335975-m6lkrehi 1026 28 review review VB cord-335975-m6lkrehi 1026 29 the the DT cord-335975-m6lkrehi 1026 30 current current JJ cord-335975-m6lkrehi 1026 31 official official JJ cord-335975-m6lkrehi 1026 32 model model NN cord-335975-m6lkrehi 1026 33 of of IN cord-335975-m6lkrehi 1026 34 DC DC NNP cord-335975-m6lkrehi 1026 35 . . . cord-335975-m6lkrehi 1027 1 Introduction introduction NN cord-335975-m6lkrehi 1027 2 : : : cord-335975-m6lkrehi 1028 1 Septic septic JJ cord-335975-m6lkrehi 1028 2 shock shock NN cord-335975-m6lkrehi 1028 3 is be VBZ cord-335975-m6lkrehi 1028 4 defined define VBN cord-335975-m6lkrehi 1028 5 as as IN cord-335975-m6lkrehi 1028 6 a a DT cord-335975-m6lkrehi 1028 7 sepsis sepsis NN cord-335975-m6lkrehi 1028 8 with with IN cord-335975-m6lkrehi 1028 9 hyperlactaemia hyperlactaemia NNP cord-335975-m6lkrehi 1028 10 greater great JJR cord-335975-m6lkrehi 1028 11 than than IN cord-335975-m6lkrehi 1028 12 2 2 CD cord-335975-m6lkrehi 1028 13 mM mm NN cord-335975-m6lkrehi 1028 14 after after IN cord-335975-m6lkrehi 1028 15 correction correction NN cord-335975-m6lkrehi 1028 16 of of IN cord-335975-m6lkrehi 1028 17 hypovolemia hypovolemia NN cord-335975-m6lkrehi 1028 18 requiring require VBG cord-335975-m6lkrehi 1028 19 vasopressors vasopressor NNS cord-335975-m6lkrehi 1028 20 to to TO cord-335975-m6lkrehi 1028 21 maintain maintain VB cord-335975-m6lkrehi 1028 22 MBP MBP NNP cord-335975-m6lkrehi 1028 23 > > XX cord-335975-m6lkrehi 1028 24 65 65 CD cord-335975-m6lkrehi 1028 25 mmHg mmhg NN cord-335975-m6lkrehi 1028 26 [ [ -LRB- cord-335975-m6lkrehi 1028 27 1 1 CD cord-335975-m6lkrehi 1028 28 ] ] -RRB- cord-335975-m6lkrehi 1028 29 . . . cord-335975-m6lkrehi 1029 1 It -PRON- PRP cord-335975-m6lkrehi 1029 2 can can MD cord-335975-m6lkrehi 1029 3 be be VB cord-335975-m6lkrehi 1029 4 observed observe VBN cord-335975-m6lkrehi 1029 5 in in IN cord-335975-m6lkrehi 1029 6 pre pre JJ cord-335975-m6lkrehi 1029 7 - - JJ cord-335975-m6lkrehi 1029 8 hospital hospital JJ cord-335975-m6lkrehi 1029 9 emergency emergency NN cord-335975-m6lkrehi 1029 10 medicine medicine NN cord-335975-m6lkrehi 1029 11 ( ( -LRB- cord-335975-m6lkrehi 1029 12 PHEM PHEM NNP cord-335975-m6lkrehi 1029 13 ) ) -RRB- cord-335975-m6lkrehi 1029 14 . . . cord-335975-m6lkrehi 1030 1 The the DT cord-335975-m6lkrehi 1030 2 use use NN cord-335975-m6lkrehi 1030 3 of of IN cord-335975-m6lkrehi 1030 4 a a DT cord-335975-m6lkrehi 1030 5 reliable reliable JJ cord-335975-m6lkrehi 1030 6 portable portable JJ cord-335975-m6lkrehi 1030 7 device device NN cord-335975-m6lkrehi 1030 8 for for IN cord-335975-m6lkrehi 1030 9 measuring measure VBG cord-335975-m6lkrehi 1030 10 lactate lactate NN cord-335975-m6lkrehi 1030 11 in in IN cord-335975-m6lkrehi 1030 12 PHEM PHEM NNP cord-335975-m6lkrehi 1030 13 would would MD cord-335975-m6lkrehi 1030 14 allow allow VB cord-335975-m6lkrehi 1030 15 a a DT cord-335975-m6lkrehi 1030 16 better well JJR cord-335975-m6lkrehi 1030 17 evaluation evaluation NN cord-335975-m6lkrehi 1030 18 of of IN cord-335975-m6lkrehi 1030 19 septic septic JJ cord-335975-m6lkrehi 1030 20 patient patient NN cord-335975-m6lkrehi 1030 21 facilitating facilitate VBG cord-335975-m6lkrehi 1030 22 their -PRON- PRP$ cord-335975-m6lkrehi 1030 23 orientation orientation NN cord-335975-m6lkrehi 1030 24 towards towards IN cord-335975-m6lkrehi 1030 25 intensive intensive JJ cord-335975-m6lkrehi 1030 26 care care NN cord-335975-m6lkrehi 1030 27 unit unit NN cord-335975-m6lkrehi 1030 28 ( ( -LRB- cord-335975-m6lkrehi 1030 29 ICU ICU NNP cord-335975-m6lkrehi 1030 30 ) ) -RRB- cord-335975-m6lkrehi 1030 31 or or CC cord-335975-m6lkrehi 1030 32 emergency emergency NN cord-335975-m6lkrehi 1030 33 department department NN cord-335975-m6lkrehi 1030 34 ( ( -LRB- cord-335975-m6lkrehi 1030 35 ED ED NNP cord-335975-m6lkrehi 1030 36 ) ) -RRB- cord-335975-m6lkrehi 1030 37 . . . cord-335975-m6lkrehi 1031 1 This this DT cord-335975-m6lkrehi 1031 2 portable portable JJ cord-335975-m6lkrehi 1031 3 delocalized delocalized JJ cord-335975-m6lkrehi 1031 4 biology biology NN cord-335975-m6lkrehi 1031 5 device device NN cord-335975-m6lkrehi 1031 6 must must MD cord-335975-m6lkrehi 1031 7 be be VB cord-335975-m6lkrehi 1031 8 validated validate VBN cord-335975-m6lkrehi 1031 9 against against IN cord-335975-m6lkrehi 1031 10 the the DT cord-335975-m6lkrehi 1031 11 laboratory laboratory NN cord-335975-m6lkrehi 1031 12 reference reference NN cord-335975-m6lkrehi 1031 13 method method NN cord-335975-m6lkrehi 1031 14 ( ( -LRB- cord-335975-m6lkrehi 1031 15 NFEN NFEN NNP cord-335975-m6lkrehi 1031 16 ISO ISO NNP cord-335975-m6lkrehi 1031 17 22870 22870 CD cord-335975-m6lkrehi 1031 18 ) ) -RRB- cord-335975-m6lkrehi 1031 19 [ [ -LRB- cord-335975-m6lkrehi 1031 20 2 2 CD cord-335975-m6lkrehi 1031 21 ] ] -RRB- cord-335975-m6lkrehi 1031 22 . . . cord-335975-m6lkrehi 1032 1 The the DT cord-335975-m6lkrehi 1032 2 aim aim NN cord-335975-m6lkrehi 1032 3 of of IN cord-335975-m6lkrehi 1032 4 this this DT cord-335975-m6lkrehi 1032 5 study study NN cord-335975-m6lkrehi 1032 6 was be VBD cord-335975-m6lkrehi 1032 7 to to TO cord-335975-m6lkrehi 1032 8 clarify clarify VB cord-335975-m6lkrehi 1032 9 the the DT cord-335975-m6lkrehi 1032 10 validity validity NN cord-335975-m6lkrehi 1032 11 of of IN cord-335975-m6lkrehi 1032 12 a a DT cord-335975-m6lkrehi 1032 13 delocalized delocalized JJ cord-335975-m6lkrehi 1032 14 measure measure NN cord-335975-m6lkrehi 1032 15 of of IN cord-335975-m6lkrehi 1032 16 lactatemia lactatemia NN cord-335975-m6lkrehi 1032 17 . . . cord-335975-m6lkrehi 1033 1 We -PRON- PRP cord-335975-m6lkrehi 1033 2 performed perform VBD cord-335975-m6lkrehi 1033 3 a a DT cord-335975-m6lkrehi 1033 4 prospective prospective JJ cord-335975-m6lkrehi 1033 5 study study NN cord-335975-m6lkrehi 1033 6 including include VBG cord-335975-m6lkrehi 1033 7 47 47 CD cord-335975-m6lkrehi 1033 8 patients patient NNS cord-335975-m6lkrehi 1033 9 admitted admit VBN cord-335975-m6lkrehi 1033 10 into into IN cord-335975-m6lkrehi 1033 11 ICU ICU NNP cord-335975-m6lkrehi 1033 12 for for IN cord-335975-m6lkrehi 1033 13 septic septic JJ cord-335975-m6lkrehi 1033 14 shock shock NN cord-335975-m6lkrehi 1033 15 ( ( -LRB- cord-335975-m6lkrehi 1033 16 CPP CPP NNP cord-335975-m6lkrehi 1033 17 number number NN cord-335975-m6lkrehi 1033 18 2015 2015 CD cord-335975-m6lkrehi 1033 19 - - HYPH cord-335975-m6lkrehi 1033 20 08 08 CD cord-335975-m6lkrehi 1033 21 - - HYPH cord-335975-m6lkrehi 1033 22 03 03 CD cord-335975-m6lkrehi 1033 23 SC SC NNP cord-335975-m6lkrehi 1033 24 ) ) -RRB- cord-335975-m6lkrehi 1033 25 . . . cord-335975-m6lkrehi 1034 1 Lactate lactate NN cord-335975-m6lkrehi 1034 2 was be VBD cord-335975-m6lkrehi 1034 3 measured measure VBN cord-335975-m6lkrehi 1034 4 in in IN cord-335975-m6lkrehi 1034 5 parallel parallel NN cord-335975-m6lkrehi 1034 6 on on IN cord-335975-m6lkrehi 1034 7 2 2 CD cord-335975-m6lkrehi 1034 8 samples sample NNS cord-335975-m6lkrehi 1034 9 - - HYPH cord-335975-m6lkrehi 1034 10 one one CD cord-335975-m6lkrehi 1034 11 capillary capillary NN cord-335975-m6lkrehi 1034 12 with with IN cord-335975-m6lkrehi 1034 13 the the DT cord-335975-m6lkrehi 1034 14 portable portable JJ cord-335975-m6lkrehi 1034 15 device device NN cord-335975-m6lkrehi 1035 1 ( ( -LRB- cord-335975-m6lkrehi 1035 2 Lactate Lactate NNP cord-335975-m6lkrehi 1035 3 StatStrip StatStrip NNP cord-335975-m6lkrehi 1035 4 Xpress Xpress NNP cord-335975-m6lkrehi 1035 5 , , , cord-335975-m6lkrehi 1035 6 Nova Nova NNP cord-335975-m6lkrehi 1035 7 Biomedical Biomedical NNP cord-335975-m6lkrehi 1035 8 ) ) -RRB- cord-335975-m6lkrehi 1035 9 and and CC cord-335975-m6lkrehi 1035 10 the the DT cord-335975-m6lkrehi 1035 11 other other JJ cord-335975-m6lkrehi 1035 12 venous venous NN cord-335975-m6lkrehi 1035 13 on on IN cord-335975-m6lkrehi 1035 14 a a DT cord-335975-m6lkrehi 1035 15 centrifuge centrifuge NN cord-335975-m6lkrehi 1035 16 tube tube NN cord-335975-m6lkrehi 1035 17 for for IN cord-335975-m6lkrehi 1035 18 plasma plasma NN cord-335975-m6lkrehi 1035 19 analysis analysis NN cord-335975-m6lkrehi 1035 20 ( ( -LRB- cord-335975-m6lkrehi 1035 21 Architect Architect NNP cord-335975-m6lkrehi 1035 22 C16000 C16000 NNP cord-335975-m6lkrehi 1035 23 Abbott Abbott NNP cord-335975-m6lkrehi 1035 24 Diagnostics Diagnostics NNP cord-335975-m6lkrehi 1035 25 ) ) -RRB- cord-335975-m6lkrehi 1035 26 . . . cord-335975-m6lkrehi 1036 1 We -PRON- PRP cord-335975-m6lkrehi 1036 2 evaluated evaluate VBD cord-335975-m6lkrehi 1036 3 the the DT cord-335975-m6lkrehi 1036 4 analytical analytical JJ cord-335975-m6lkrehi 1036 5 performance performance NN cord-335975-m6lkrehi 1036 6 ( ( -LRB- cord-335975-m6lkrehi 1036 7 coefficients coefficient NNS cord-335975-m6lkrehi 1036 8 of of IN cord-335975-m6lkrehi 1036 9 variation variation NN cord-335975-m6lkrehi 1036 10 ( ( -LRB- cord-335975-m6lkrehi 1036 11 CV CV NNP cord-335975-m6lkrehi 1036 12 ) ) -RRB- cord-335975-m6lkrehi 1036 13 for for IN cord-335975-m6lkrehi 1036 14 repeatability repeatability NN cord-335975-m6lkrehi 1036 15 and and CC cord-335975-m6lkrehi 1036 16 reproducibility reproducibility NN cord-335975-m6lkrehi 1036 17 evaluated evaluate VBN cord-335975-m6lkrehi 1036 18 at at IN cord-335975-m6lkrehi 1036 19 2 2 CD cord-335975-m6lkrehi 1036 20 levels level NNS cord-335975-m6lkrehi 1036 21 of of IN cord-335975-m6lkrehi 1036 22 quality quality NN cord-335975-m6lkrehi 1036 23 control control NN cord-335975-m6lkrehi 1036 24 ( ( -LRB- cord-335975-m6lkrehi 1036 25 QC)-1.6 QC)-1.6 NNP cord-335975-m6lkrehi 1036 26 and and CC cord-335975-m6lkrehi 1036 27 3.6 3.6 CD cord-335975-m6lkrehi 1036 28 mM mm CD cord-335975-m6lkrehi 1036 29 ) ) -RRB- cord-335975-m6lkrehi 1036 30 and and CC cord-335975-m6lkrehi 1036 31 then then RB cord-335975-m6lkrehi 1036 32 the the DT cord-335975-m6lkrehi 1036 33 concordance concordance NN cord-335975-m6lkrehi 1036 34 between between IN cord-335975-m6lkrehi 1036 35 lactate lactate NN cord-335975-m6lkrehi 1036 36 levels level NNS cord-335975-m6lkrehi 1036 37 measured measure VBN cord-335975-m6lkrehi 1036 38 by by IN cord-335975-m6lkrehi 1036 39 the the DT cord-335975-m6lkrehi 1036 40 devices device NNS cord-335975-m6lkrehi 1036 41 and and CC cord-335975-m6lkrehi 1036 42 lactate lactate NN cord-335975-m6lkrehi 1036 43 levels level NNS cord-335975-m6lkrehi 1036 44 measured measure VBN cord-335975-m6lkrehi 1036 45 by by IN cord-335975-m6lkrehi 1036 46 laboratory laboratory NN cord-335975-m6lkrehi 1036 47 analyzer analyzer NN cord-335975-m6lkrehi 1036 48 . . . cord-335975-m6lkrehi 1037 1 Results result NNS cord-335975-m6lkrehi 1037 2 : : : cord-335975-m6lkrehi 1038 1 At at IN cord-335975-m6lkrehi 1038 2 the the DT cord-335975-m6lkrehi 1038 3 QC QC NNP cord-335975-m6lkrehi 1038 4 concentrations concentration NNS cord-335975-m6lkrehi 1038 5 tested test VBN cord-335975-m6lkrehi 1038 6 , , , cord-335975-m6lkrehi 1038 7 the the DT cord-335975-m6lkrehi 1038 8 CVs cv NNS cord-335975-m6lkrehi 1038 9 were be VBD cord-335975-m6lkrehi 1038 10 in in IN cord-335975-m6lkrehi 1038 11 agreement agreement NN cord-335975-m6lkrehi 1038 12 with with IN cord-335975-m6lkrehi 1038 13 the the DT cord-335975-m6lkrehi 1038 14 limits limit NNS cord-335975-m6lkrehi 1038 15 set set VBN cord-335975-m6lkrehi 1038 16 by by IN cord-335975-m6lkrehi 1038 17 the the DT cord-335975-m6lkrehi 1038 18 French French NNP cord-335975-m6lkrehi 1038 19 Society Society NNP cord-335975-m6lkrehi 1038 20 of of IN cord-335975-m6lkrehi 1038 21 Clinical Clinical NNP cord-335975-m6lkrehi 1038 22 Biology Biology NNP cord-335975-m6lkrehi 1038 23 - - HYPH cord-335975-m6lkrehi 1038 24 CV cv NN cord-335975-m6lkrehi 1038 25 < < XX cord-335975-m6lkrehi 1038 26 3 3 CD cord-335975-m6lkrehi 1038 27 % % NN cord-335975-m6lkrehi 1038 28 for for IN cord-335975-m6lkrehi 1038 29 repeatability repeatability NN cord-335975-m6lkrehi 1038 30 and and CC cord-335975-m6lkrehi 1038 31 < < XX cord-335975-m6lkrehi 1038 32 5 5 CD cord-335975-m6lkrehi 1038 33 % % NN cord-335975-m6lkrehi 1038 34 for for IN cord-335975-m6lkrehi 1038 35 reproducibility reproducibility NN cord-335975-m6lkrehi 1038 36 . . . cord-335975-m6lkrehi 1039 1 An an DT cord-335975-m6lkrehi 1039 2 excellent excellent JJ cord-335975-m6lkrehi 1039 3 correlation correlation NN cord-335975-m6lkrehi 1039 4 was be VBD cord-335975-m6lkrehi 1039 5 observed observe VBN cord-335975-m6lkrehi 1039 6 between between IN cord-335975-m6lkrehi 1039 7 the the DT cord-335975-m6lkrehi 1039 8 2 2 CD cord-335975-m6lkrehi 1039 9 measurements measurement NNS cord-335975-m6lkrehi 1039 10 - - HYPH cord-335975-m6lkrehi 1039 11 correlation correlation NN cord-335975-m6lkrehi 1039 12 coefficient coefficient NN cord-335975-m6lkrehi 1039 13 R2 r2 NN cord-335975-m6lkrehi 1039 14 = = SYM cord-335975-m6lkrehi 1039 15 0.98 0.98 CD cord-335975-m6lkrehi 1039 16 , , , cord-335975-m6lkrehi 1039 17 slope slope NN cord-335975-m6lkrehi 1039 18 = = SYM cord-335975-m6lkrehi 1039 19 0.95 0.95 CD cord-335975-m6lkrehi 1039 20 and and CC cord-335975-m6lkrehi 1039 21 ordered order VBN cord-335975-m6lkrehi 1039 22 at at IN cord-335975-m6lkrehi 1039 23 the the DT cord-335975-m6lkrehi 1039 24 origin origin NN cord-335975-m6lkrehi 1039 25 = = VBZ cord-335975-m6lkrehi 1039 26 0.1 0.1 CD cord-335975-m6lkrehi 1039 27 . . . cord-335975-m6lkrehi 1040 1 The the DT cord-335975-m6lkrehi 1040 2 latter latter NN cord-335975-m6lkrehi 1040 3 suggested suggest VBD cord-335975-m6lkrehi 1040 4 a a DT cord-335975-m6lkrehi 1040 5 low low JJ cord-335975-m6lkrehi 1040 6 positive positive JJ cord-335975-m6lkrehi 1040 7 bias bias NN cord-335975-m6lkrehi 1040 8 of of IN cord-335975-m6lkrehi 1040 9 the the DT cord-335975-m6lkrehi 1040 10 device device NN cord-335975-m6lkrehi 1040 11 not not RB cord-335975-m6lkrehi 1040 12 confirmed confirm VBN cord-335975-m6lkrehi 1040 13 by by IN cord-335975-m6lkrehi 1040 14 Bland Bland NNP cord-335975-m6lkrehi 1040 15 - - HYPH cord-335975-m6lkrehi 1040 16 Altmann Altmann NNP cord-335975-m6lkrehi 1040 17 graph graph NN cord-335975-m6lkrehi 1040 18 analysis analysis NN cord-335975-m6lkrehi 1040 19 and and CC cord-335975-m6lkrehi 1040 20 graph graph NN cord-335975-m6lkrehi 1040 21 of of IN cord-335975-m6lkrehi 1040 22 the the DT cord-335975-m6lkrehi 1040 23 differences difference NNS cord-335975-m6lkrehi 1040 24 . . . cord-335975-m6lkrehi 1041 1 We -PRON- PRP cord-335975-m6lkrehi 1041 2 verified verify VBD cord-335975-m6lkrehi 1041 3 the the DT cord-335975-m6lkrehi 1041 4 analytical analytical JJ cord-335975-m6lkrehi 1041 5 performance performance NN cord-335975-m6lkrehi 1041 6 of of IN cord-335975-m6lkrehi 1041 7 the the DT cord-335975-m6lkrehi 1041 8 device device NN cord-335975-m6lkrehi 1041 9 and and CC cord-335975-m6lkrehi 1041 10 showed show VBD cord-335975-m6lkrehi 1041 11 an an DT cord-335975-m6lkrehi 1041 12 excellent excellent JJ cord-335975-m6lkrehi 1041 13 correlation correlation NN cord-335975-m6lkrehi 1041 14 with with IN cord-335975-m6lkrehi 1041 15 the the DT cord-335975-m6lkrehi 1041 16 laboratory laboratory NN cord-335975-m6lkrehi 1041 17 measurement measurement NN cord-335975-m6lkrehi 1041 18 . . . cord-335975-m6lkrehi 1042 1 The the DT cord-335975-m6lkrehi 1042 2 delocalized delocalized JJ cord-335975-m6lkrehi 1042 3 measure measure NN cord-335975-m6lkrehi 1042 4 can can MD cord-335975-m6lkrehi 1042 5 be be VB cord-335975-m6lkrehi 1042 6 used use VBN cord-335975-m6lkrehi 1042 7 in in IN cord-335975-m6lkrehi 1042 8 PHEM PHEM NNP cord-335975-m6lkrehi 1042 9 in in IN cord-335975-m6lkrehi 1042 10 patients patient NNS cord-335975-m6lkrehi 1042 11 with with IN cord-335975-m6lkrehi 1042 12 suspected suspect VBN cord-335975-m6lkrehi 1042 13 sepsis sepsis NN cord-335975-m6lkrehi 1042 14 syndrome syndrome NN cord-335975-m6lkrehi 1042 15 . . . cord-335975-m6lkrehi 1043 1 This this DT cord-335975-m6lkrehi 1043 2 measure measure NN cord-335975-m6lkrehi 1043 3 should should MD cord-335975-m6lkrehi 1043 4 allow allow VB cord-335975-m6lkrehi 1043 5 a a DT cord-335975-m6lkrehi 1043 6 more more RBR cord-335975-m6lkrehi 1043 7 accurate accurate JJ cord-335975-m6lkrehi 1043 8 and and CC cord-335975-m6lkrehi 1043 9 early early JJ cord-335975-m6lkrehi 1043 10 assessment assessment NN cord-335975-m6lkrehi 1043 11 of of IN cord-335975-m6lkrehi 1043 12 their -PRON- PRP$ cord-335975-m6lkrehi 1043 13 severity severity NN cord-335975-m6lkrehi 1043 14 in in IN cord-335975-m6lkrehi 1043 15 order order NN cord-335975-m6lkrehi 1043 16 to to TO cord-335975-m6lkrehi 1043 17 improve improve VB cord-335975-m6lkrehi 1043 18 triage triage NN cord-335975-m6lkrehi 1043 19 and and CC cord-335975-m6lkrehi 1043 20 hospital hospital NN cord-335975-m6lkrehi 1043 21 orientation orientation NN cord-335975-m6lkrehi 1043 22 between between IN cord-335975-m6lkrehi 1043 23 ED ED NNP cord-335975-m6lkrehi 1043 24 and and CC cord-335975-m6lkrehi 1043 25 ICU ICU NNP cord-335975-m6lkrehi 1043 26 . . . cord-335975-m6lkrehi 1043 27 _SP cord-335975-m6lkrehi 1044 1 There there EX cord-335975-m6lkrehi 1044 2 is be VBZ cord-335975-m6lkrehi 1044 3 an an DT cord-335975-m6lkrehi 1044 4 association association NN cord-335975-m6lkrehi 1044 5 between between IN cord-335975-m6lkrehi 1044 6 mortality mortality NN cord-335975-m6lkrehi 1044 7 at at IN cord-335975-m6lkrehi 1044 8 D28 D28 NNP cord-335975-m6lkrehi 1044 9 and and CC cord-335975-m6lkrehi 1044 10 hyperoxia hyperoxia NN cord-335975-m6lkrehi 1044 11 in in IN cord-335975-m6lkrehi 1044 12 patients patient NNS cord-335975-m6lkrehi 1044 13 admitted admit VBN cord-335975-m6lkrehi 1044 14 in in IN cord-335975-m6lkrehi 1044 15 ICU ICU NNP cord-335975-m6lkrehi 1044 16 for for IN cord-335975-m6lkrehi 1044 17 refractory refractory JJ cord-335975-m6lkrehi 1044 18 OHCA OHCA NNP cord-335975-m6lkrehi 1044 19 requiring require VBG cord-335975-m6lkrehi 1044 20 eCPR ecpr NN cord-335975-m6lkrehi 1044 21 . . . cord-335975-m6lkrehi 1045 1 These these DT cord-335975-m6lkrehi 1045 2 data datum NNS cord-335975-m6lkrehi 1045 3 underline underline VBP cord-335975-m6lkrehi 1045 4 the the DT cord-335975-m6lkrehi 1045 5 potential potential JJ cord-335975-m6lkrehi 1045 6 toxicity toxicity NN cord-335975-m6lkrehi 1045 7 of of IN cord-335975-m6lkrehi 1045 8 high high JJ cord-335975-m6lkrehi 1045 9 dose dose NN cord-335975-m6lkrehi 1045 10 of of IN cord-335975-m6lkrehi 1045 11 oxygen oxygen NN cord-335975-m6lkrehi 1045 12 and and CC cord-335975-m6lkrehi 1045 13 suggest suggest VBP cord-335975-m6lkrehi 1045 14 that that DT cord-335975-m6lkrehi 1045 15 control control NN cord-335975-m6lkrehi 1045 16 of of IN cord-335975-m6lkrehi 1045 17 oxygen oxygen NN cord-335975-m6lkrehi 1045 18 administration administration NN cord-335975-m6lkrehi 1045 19 in in IN cord-335975-m6lkrehi 1045 20 such such JJ cord-335975-m6lkrehi 1045 21 patients patient NNS cord-335975-m6lkrehi 1045 22 is be VBZ cord-335975-m6lkrehi 1045 23 an an DT cord-335975-m6lkrehi 1045 24 important important JJ cord-335975-m6lkrehi 1045 25 part part NN cord-335975-m6lkrehi 1045 26 of of IN cord-335975-m6lkrehi 1045 27 the the DT cord-335975-m6lkrehi 1045 28 treatment treatment NN cord-335975-m6lkrehi 1045 29 . . . cord-335975-m6lkrehi 1046 1 A a DT cord-335975-m6lkrehi 1046 2 value value NN cord-335975-m6lkrehi 1046 3 of of IN cord-335975-m6lkrehi 1046 4 PaO2 PaO2 NNS cord-335975-m6lkrehi 1046 5 between between IN cord-335975-m6lkrehi 1046 6 100 100 CD cord-335975-m6lkrehi 1046 7 and and CC cord-335975-m6lkrehi 1046 8 300 300 CD cord-335975-m6lkrehi 1046 9 mmHg mmHg NNS cord-335975-m6lkrehi 1046 10 after after IN cord-335975-m6lkrehi 1046 11 starting start VBG cord-335975-m6lkrehi 1046 12 eCPR eCPR NNP cord-335975-m6lkrehi 1046 13 seems seem VBZ cord-335975-m6lkrehi 1046 14 to to TO cord-335975-m6lkrehi 1046 15 be be VB cord-335975-m6lkrehi 1046 16 a a DT cord-335975-m6lkrehi 1046 17 target target NN cord-335975-m6lkrehi 1046 18 during during IN cord-335975-m6lkrehi 1046 19 treatment treatment NN cord-335975-m6lkrehi 1046 20 of of IN cord-335975-m6lkrehi 1046 21 OHCA OHCA NNP cord-335975-m6lkrehi 1046 22 treated treat VBN cord-335975-m6lkrehi 1046 23 by by IN cord-335975-m6lkrehi 1046 24 eCPR eCPR NNP cord-335975-m6lkrehi 1046 25 . . . cord-335975-m6lkrehi 1047 1 Introduction introduction NN cord-335975-m6lkrehi 1047 2 : : : cord-335975-m6lkrehi 1048 1 Sepsis sepsis NN cord-335975-m6lkrehi 1048 2 has have VBZ cord-335975-m6lkrehi 1048 3 been be VBN cord-335975-m6lkrehi 1048 4 defined define VBN cord-335975-m6lkrehi 1048 5 as as IN cord-335975-m6lkrehi 1048 6 a a DT cord-335975-m6lkrehi 1048 7 dysregulated dysregulate VBN cord-335975-m6lkrehi 1048 8 host host NN cord-335975-m6lkrehi 1048 9 response response NN cord-335975-m6lkrehi 1048 10 to to IN cord-335975-m6lkrehi 1048 11 infection infection NN cord-335975-m6lkrehi 1048 12 leading lead VBG cord-335975-m6lkrehi 1048 13 to to IN cord-335975-m6lkrehi 1048 14 life life NN cord-335975-m6lkrehi 1048 15 - - HYPH cord-335975-m6lkrehi 1048 16 threatening threaten VBG cord-335975-m6lkrehi 1048 17 organ organ NN cord-335975-m6lkrehi 1048 18 dysfunction dysfunction NN cord-335975-m6lkrehi 1049 1 ( ( -LRB- cord-335975-m6lkrehi 1049 2 Singer singer NN cord-335975-m6lkrehi 1049 3 M M NNP cord-335975-m6lkrehi 1049 4 et et NNP cord-335975-m6lkrehi 1049 5 al al NNP cord-335975-m6lkrehi 1049 6 . . NNP cord-335975-m6lkrehi 1049 7 , , , cord-335975-m6lkrehi 1049 8 JAMA JAMA NNP cord-335975-m6lkrehi 1049 9 2016 2016 CD cord-335975-m6lkrehi 1049 10 ) ) -RRB- cord-335975-m6lkrehi 1049 11 . . . cord-335975-m6lkrehi 1050 1 A a DT cord-335975-m6lkrehi 1050 2 qSOFA qsofa JJ cord-335975-m6lkrehi 1050 3 score score NN cord-335975-m6lkrehi 1050 4 relying rely VBG cord-335975-m6lkrehi 1050 5 on on IN cord-335975-m6lkrehi 1050 6 3 3 CD cord-335975-m6lkrehi 1050 7 simple simple JJ cord-335975-m6lkrehi 1050 8 clinical clinical JJ cord-335975-m6lkrehi 1050 9 criteria criterion NNS cord-335975-m6lkrehi 1050 10 ( ( -LRB- cord-335975-m6lkrehi 1050 11 respiratory respiratory JJ cord-335975-m6lkrehi 1050 12 rate rate NN cord-335975-m6lkrehi 1050 13 , , , cord-335975-m6lkrehi 1050 14 mental mental JJ cord-335975-m6lkrehi 1050 15 status status NN cord-335975-m6lkrehi 1050 16 and and CC cord-335975-m6lkrehi 1050 17 systolic systolic JJ cord-335975-m6lkrehi 1050 18 blood blood NN cord-335975-m6lkrehi 1050 19 pressure pressure NN cord-335975-m6lkrehi 1050 20 ) ) -RRB- cord-335975-m6lkrehi 1050 21 has have VBZ cord-335975-m6lkrehi 1050 22 been be VBN cord-335975-m6lkrehi 1050 23 proposed propose VBN cord-335975-m6lkrehi 1050 24 to to TO cord-335975-m6lkrehi 1050 25 better better RB cord-335975-m6lkrehi 1050 26 identify identify VB cord-335975-m6lkrehi 1050 27 septic septic JJ cord-335975-m6lkrehi 1050 28 patients patient NNS cord-335975-m6lkrehi 1050 29 with with IN cord-335975-m6lkrehi 1050 30 associated associated JJ cord-335975-m6lkrehi 1050 31 higher high JJR cord-335975-m6lkrehi 1050 32 mortality mortality NN cord-335975-m6lkrehi 1050 33 outside outside IN cord-335975-m6lkrehi 1050 34 the the DT cord-335975-m6lkrehi 1050 35 intensive intensive JJ cord-335975-m6lkrehi 1050 36 care care NN cord-335975-m6lkrehi 1050 37 unit unit NN cord-335975-m6lkrehi 1050 38 ( ( -LRB- cord-335975-m6lkrehi 1050 39 Seymour Seymour NNP cord-335975-m6lkrehi 1050 40 CW CW NNP cord-335975-m6lkrehi 1050 41 et et FW cord-335975-m6lkrehi 1050 42 al al NNP cord-335975-m6lkrehi 1050 43 . . NNP cord-335975-m6lkrehi 1050 44 , , , cord-335975-m6lkrehi 1050 45 JAMA JAMA NNP cord-335975-m6lkrehi 1050 46 2016 2016 CD cord-335975-m6lkrehi 1050 47 ) ) -RRB- cord-335975-m6lkrehi 1050 48 . . . cord-335975-m6lkrehi 1051 1 The the DT cord-335975-m6lkrehi 1051 2 study study NN cord-335975-m6lkrehi 1051 3 aim aim NN cord-335975-m6lkrehi 1051 4 was be VBD cord-335975-m6lkrehi 1051 5 to to TO cord-335975-m6lkrehi 1051 6 evaluate evaluate VB cord-335975-m6lkrehi 1051 7 the the DT cord-335975-m6lkrehi 1051 8 ability ability NN cord-335975-m6lkrehi 1051 9 of of IN cord-335975-m6lkrehi 1051 10 qSOFA qsofa NN cord-335975-m6lkrehi 1051 11 to to TO cord-335975-m6lkrehi 1051 12 predict predict VB cord-335975-m6lkrehi 1051 13 the the DT cord-335975-m6lkrehi 1051 14 development development NN cord-335975-m6lkrehi 1051 15 of of IN cord-335975-m6lkrehi 1051 16 organ organ NN cord-335975-m6lkrehi 1051 17 failure failure NN cord-335975-m6lkrehi 1051 18 and and CC cord-335975-m6lkrehi 1051 19 increased increase VBD cord-335975-m6lkrehi 1051 20 28-day 28-day CD cord-335975-m6lkrehi 1051 21 mortality mortality NN cord-335975-m6lkrehi 1051 22 in in IN cord-335975-m6lkrehi 1051 23 patients patient NNS cord-335975-m6lkrehi 1051 24 admitted admit VBN cord-335975-m6lkrehi 1051 25 for for IN cord-335975-m6lkrehi 1051 26 suspected suspect VBN cord-335975-m6lkrehi 1051 27 sepsis sepsis NN cord-335975-m6lkrehi 1051 28 in in IN cord-335975-m6lkrehi 1051 29 the the DT cord-335975-m6lkrehi 1051 30 Emergency Emergency NNP cord-335975-m6lkrehi 1051 31 Department Department NNP cord-335975-m6lkrehi 1051 32 ( ( -LRB- cord-335975-m6lkrehi 1051 33 ED ED NNP cord-335975-m6lkrehi 1051 34 ) ) -RRB- cord-335975-m6lkrehi 1051 35 . . . cord-335975-m6lkrehi 1052 1 Patients patient NNS cord-335975-m6lkrehi 1052 2 and and CC cord-335975-m6lkrehi 1052 3 methods method NNS cord-335975-m6lkrehi 1052 4 : : : cord-335975-m6lkrehi 1052 5 Prospective prospective JJ cord-335975-m6lkrehi 1052 6 study study NN cord-335975-m6lkrehi 1052 7 conducted conduct VBN cord-335975-m6lkrehi 1052 8 over over IN cord-335975-m6lkrehi 1052 9 a a DT cord-335975-m6lkrehi 1052 10 period period NN cord-335975-m6lkrehi 1052 11 of of IN cord-335975-m6lkrehi 1052 12 6 6 CD cord-335975-m6lkrehi 1052 13 months month NNS cord-335975-m6lkrehi 1052 14 comparing compare VBG cord-335975-m6lkrehi 1052 15 the the DT cord-335975-m6lkrehi 1052 16 prevalence prevalence NN cord-335975-m6lkrehi 1052 17 of of IN cord-335975-m6lkrehi 1052 18 organ organ NN cord-335975-m6lkrehi 1052 19 failure failure NN cord-335975-m6lkrehi 1052 20 and and CC cord-335975-m6lkrehi 1052 21 28-day 28-day CD cord-335975-m6lkrehi 1052 22 mortality mortality NN cord-335975-m6lkrehi 1052 23 according accord VBG cord-335975-m6lkrehi 1052 24 to to IN cord-335975-m6lkrehi 1052 25 the the DT cord-335975-m6lkrehi 1052 26 value value NN cord-335975-m6lkrehi 1052 27 of of IN cord-335975-m6lkrehi 1052 28 qSOFA qsofa NN cord-335975-m6lkrehi 1052 29 at at IN cord-335975-m6lkrehi 1052 30 admission admission NN cord-335975-m6lkrehi 1052 31 to to IN cord-335975-m6lkrehi 1052 32 the the DT cord-335975-m6lkrehi 1052 33 ED ED NNP cord-335975-m6lkrehi 1052 34 between between IN cord-335975-m6lkrehi 1052 35 group group NN cord-335975-m6lkrehi 1052 36 A A NNP cord-335975-m6lkrehi 1052 37 ( ( -LRB- cord-335975-m6lkrehi 1052 38 qSOFA qsofa NN cord-335975-m6lkrehi 1052 39 > > XX cord-335975-m6lkrehi 1052 40 = = SYM cord-335975-m6lkrehi 1052 41 2 2 CD cord-335975-m6lkrehi 1052 42 ) ) -RRB- cord-335975-m6lkrehi 1052 43 and and CC cord-335975-m6lkrehi 1052 44 group group NN cord-335975-m6lkrehi 1052 45 B B NNP cord-335975-m6lkrehi 1052 46 ( ( -LRB- cord-335975-m6lkrehi 1052 47 qSOFA qSOFA NNP cord-335975-m6lkrehi 1052 48 < < XX cord-335975-m6lkrehi 1052 49 2 2 CD cord-335975-m6lkrehi 1052 50 ) ) -RRB- cord-335975-m6lkrehi 1052 51 . . . cord-335975-m6lkrehi 1053 1 As as IN cord-335975-m6lkrehi 1053 2 part part NN cord-335975-m6lkrehi 1053 3 of of IN cord-335975-m6lkrehi 1053 4 routine routine JJ cord-335975-m6lkrehi 1053 5 care care NN cord-335975-m6lkrehi 1053 6 , , , cord-335975-m6lkrehi 1053 7 an an DT cord-335975-m6lkrehi 1053 8 electronic electronic JJ cord-335975-m6lkrehi 1053 9 sepsis sepsis NN cord-335975-m6lkrehi 1053 10 form form NN cord-335975-m6lkrehi 1053 11 was be VBD cord-335975-m6lkrehi 1053 12 specifically specifically RB cord-335975-m6lkrehi 1053 13 created create VBN cord-335975-m6lkrehi 1053 14 to to TO cord-335975-m6lkrehi 1053 15 identify identify VB cord-335975-m6lkrehi 1053 16 prospectively prospectively RB cord-335975-m6lkrehi 1053 17 and and CC cord-335975-m6lkrehi 1053 18 exhaustively exhaustively RB cord-335975-m6lkrehi 1053 19 all all DT cord-335975-m6lkrehi 1053 20 eligible eligible JJ cord-335975-m6lkrehi 1053 21 patients patient NNS cord-335975-m6lkrehi 1053 22 on on IN cord-335975-m6lkrehi 1053 23 - - HYPH cord-335975-m6lkrehi 1053 24 line line NN cord-335975-m6lkrehi 1053 25 . . . cord-335975-m6lkrehi 1054 1 For for IN cord-335975-m6lkrehi 1054 2 the the DT cord-335975-m6lkrehi 1054 3 purpose purpose NN cord-335975-m6lkrehi 1054 4 of of IN cord-335975-m6lkrehi 1054 5 the the DT cord-335975-m6lkrehi 1054 6 study study NN cord-335975-m6lkrehi 1054 7 , , , cord-335975-m6lkrehi 1054 8 sepsis sepsis NN cord-335975-m6lkrehi 1054 9 diagnosis diagnosis NN cord-335975-m6lkrehi 1054 10 was be VBD cord-335975-m6lkrehi 1054 11 independently independently RB cord-335975-m6lkrehi 1054 12 validated validate VBN cord-335975-m6lkrehi 1054 13 off off IN cord-335975-m6lkrehi 1054 14 - - HYPH cord-335975-m6lkrehi 1054 15 line line NN cord-335975-m6lkrehi 1054 16 by by IN cord-335975-m6lkrehi 1054 17 an an DT cord-335975-m6lkrehi 1054 18 adjudication adjudication NN cord-335975-m6lkrehi 1054 19 committee committee NN cord-335975-m6lkrehi 1054 20 which which WDT cord-335975-m6lkrehi 1054 21 included include VBD cord-335975-m6lkrehi 1054 22 three three CD cord-335975-m6lkrehi 1054 23 physicians physician NNS cord-335975-m6lkrehi 1054 24 who who WP cord-335975-m6lkrehi 1054 25 reviewed review VBD cord-335975-m6lkrehi 1054 26 clinical clinical JJ cord-335975-m6lkrehi 1054 27 , , , cord-335975-m6lkrehi 1054 28 biological biological JJ cord-335975-m6lkrehi 1054 29 and and CC cord-335975-m6lkrehi 1054 30 microbiological microbiological JJ cord-335975-m6lkrehi 1054 31 data datum NNS cord-335975-m6lkrehi 1054 32 . . . cord-335975-m6lkrehi 1055 1 For for IN cord-335975-m6lkrehi 1055 2 each each DT cord-335975-m6lkrehi 1055 3 patient patient JJ cord-335975-m6lkrehi 1055 4 , , , cord-335975-m6lkrehi 1055 5 demographic demographic JJ cord-335975-m6lkrehi 1055 6 data datum NNS cord-335975-m6lkrehi 1055 7 , , , cord-335975-m6lkrehi 1055 8 source source NN cord-335975-m6lkrehi 1055 9 of of IN cord-335975-m6lkrehi 1055 10 infection infection NN cord-335975-m6lkrehi 1055 11 , , , cord-335975-m6lkrehi 1055 12 qSOFA qsofa NN cord-335975-m6lkrehi 1055 13 and and CC cord-335975-m6lkrehi 1055 14 SOFA sofa NN cord-335975-m6lkrehi 1055 15 score score NN cord-335975-m6lkrehi 1055 16 , , , cord-335975-m6lkrehi 1055 17 biological biological JJ cord-335975-m6lkrehi 1055 18 data datum NNS cord-335975-m6lkrehi 1055 19 and and CC cord-335975-m6lkrehi 1055 20 28-day 28-day CD cord-335975-m6lkrehi 1055 21 mortality mortality NN cord-335975-m6lkrehi 1055 22 were be VBD cord-335975-m6lkrehi 1055 23 recorded record VBN cord-335975-m6lkrehi 1055 24 . . . cord-335975-m6lkrehi 1056 1 Seventy seventy CD cord-335975-m6lkrehi 1056 2 - - HYPH cord-335975-m6lkrehi 1056 3 six six CD cord-335975-m6lkrehi 1056 4 patients patient NNS cord-335975-m6lkrehi 1056 5 of of IN cord-335975-m6lkrehi 1056 6 group group NN cord-335975-m6lkrehi 1056 7 A a NN cord-335975-m6lkrehi 1056 8 ( ( -LRB- cord-335975-m6lkrehi 1056 9 99 99 CD cord-335975-m6lkrehi 1056 10 % % NN cord-335975-m6lkrehi 1056 11 ) ) -RRB- cord-335975-m6lkrehi 1056 12 were be VBD cord-335975-m6lkrehi 1056 13 hospitalized hospitalize VBN cord-335975-m6lkrehi 1056 14 , , , cord-335975-m6lkrehi 1056 15 of of IN cord-335975-m6lkrehi 1056 16 whom whom WP cord-335975-m6lkrehi 1056 17 25 25 CD cord-335975-m6lkrehi 1056 18 were be VBD cord-335975-m6lkrehi 1056 19 admitted admit VBN cord-335975-m6lkrehi 1056 20 to to IN cord-335975-m6lkrehi 1056 21 the the DT cord-335975-m6lkrehi 1056 22 intensive intensive JJ cord-335975-m6lkrehi 1056 23 care care NN cord-335975-m6lkrehi 1056 24 unit unit NN cord-335975-m6lkrehi 1056 25 ( ( -LRB- cord-335975-m6lkrehi 1056 26 32.5 32.5 CD cord-335975-m6lkrehi 1056 27 % % NN cord-335975-m6lkrehi 1056 28 ) ) -RRB- cord-335975-m6lkrehi 1056 29 , , , cord-335975-m6lkrehi 1056 30 and and CC cord-335975-m6lkrehi 1056 31 28-day 28-day CD cord-335975-m6lkrehi 1056 32 mortality mortality NN cord-335975-m6lkrehi 1056 33 reached reach VBD cord-335975-m6lkrehi 1056 34 46.7 46.7 CD cord-335975-m6lkrehi 1056 35 % % NN cord-335975-m6lkrehi 1056 36 . . . cord-335975-m6lkrehi 1057 1 In in IN cord-335975-m6lkrehi 1057 2 group group NN cord-335975-m6lkrehi 1057 3 B b NN cord-335975-m6lkrehi 1057 4 , , , cord-335975-m6lkrehi 1057 5 only only RB cord-335975-m6lkrehi 1057 6 32 32 CD cord-335975-m6lkrehi 1057 7 patients patient NNS cord-335975-m6lkrehi 1057 8 developed develop VBD cord-335975-m6lkrehi 1057 9 an an DT cord-335975-m6lkrehi 1057 10 organ organ NN cord-335975-m6lkrehi 1057 11 failure failure NN cord-335975-m6lkrehi 1057 12 ( ( -LRB- cord-335975-m6lkrehi 1057 13 10.7 10.7 CD cord-335975-m6lkrehi 1057 14 % % NN cord-335975-m6lkrehi 1057 15 ) ) -RRB- cord-335975-m6lkrehi 1057 16 and and CC cord-335975-m6lkrehi 1057 17 28-day 28-day CD cord-335975-m6lkrehi 1057 18 mortality mortality NN cord-335975-m6lkrehi 1057 19 was be VBD cord-335975-m6lkrehi 1057 20 4.3 4.3 CD cord-335975-m6lkrehi 1057 21 % % NN cord-335975-m6lkrehi 1057 22 ( ( -LRB- cord-335975-m6lkrehi 1057 23 Table table NN cord-335975-m6lkrehi 1057 24 1 1 CD cord-335975-m6lkrehi 1057 25 ) ) -RRB- cord-335975-m6lkrehi 1057 26 . . . cord-335975-m6lkrehi 1058 1 The the DT cord-335975-m6lkrehi 1058 2 present present JJ cord-335975-m6lkrehi 1058 3 study study NN cord-335975-m6lkrehi 1058 4 confirmed confirm VBD cord-335975-m6lkrehi 1058 5 that that IN cord-335975-m6lkrehi 1058 6 the the DT cord-335975-m6lkrehi 1058 7 qSOFA qsofa JJ cord-335975-m6lkrehi 1058 8 score score NN cord-335975-m6lkrehi 1058 9 is be VBZ cord-335975-m6lkrehi 1058 10 a a DT cord-335975-m6lkrehi 1058 11 reliable reliable JJ cord-335975-m6lkrehi 1058 12 and and CC cord-335975-m6lkrehi 1058 13 practical practical JJ cord-335975-m6lkrehi 1058 14 tool tool NN cord-335975-m6lkrehi 1058 15 to to TO cord-335975-m6lkrehi 1058 16 predict predict VB cord-335975-m6lkrehi 1058 17 the the DT cord-335975-m6lkrehi 1058 18 development development NN cord-335975-m6lkrehi 1058 19 of of IN cord-335975-m6lkrehi 1058 20 organ organ NN cord-335975-m6lkrehi 1058 21 failure failure NN cord-335975-m6lkrehi 1058 22 and and CC cord-335975-m6lkrehi 1058 23 higher high JJR cord-335975-m6lkrehi 1058 24 28-day 28-day CD cord-335975-m6lkrehi 1058 25 mortality mortality NN cord-335975-m6lkrehi 1058 26 in in IN cord-335975-m6lkrehi 1058 27 patients patient NNS cord-335975-m6lkrehi 1058 28 with with IN cord-335975-m6lkrehi 1058 29 suspected suspect VBN cord-335975-m6lkrehi 1058 30 sepsis sepsis NN cord-335975-m6lkrehi 1058 31 in in IN cord-335975-m6lkrehi 1058 32 the the DT cord-335975-m6lkrehi 1058 33 ED ED NNP cord-335975-m6lkrehi 1058 34 . . . cord-335975-m6lkrehi 1059 1 Limits limit NNS cord-335975-m6lkrehi 1059 2 of of IN cord-335975-m6lkrehi 1059 3 CT CT NNP cord-335975-m6lkrehi 1059 4 scan scan JJ cord-335975-m6lkrehi 1059 5 criteria criterion NNS cord-335975-m6lkrehi 1059 6 and and CC cord-335975-m6lkrehi 1059 7 intravascular intravascular JJ cord-335975-m6lkrehi 1059 8 contrast contrast NN cord-335975-m6lkrehi 1059 9 extravasation extravasation NN cord-335975-m6lkrehi 1059 10 to to TO cord-335975-m6lkrehi 1059 11 define define VB cord-335975-m6lkrehi 1059 12 pelvic pelvic JJ cord-335975-m6lkrehi 1059 13 angioembolization angioembolization NN cord-335975-m6lkrehi 1059 14 need need NN cord-335975-m6lkrehi 1059 15 : : : cord-335975-m6lkrehi 1059 16 a a DT cord-335975-m6lkrehi 1059 17 specific specific JJ cord-335975-m6lkrehi 1059 18 assessment assessment NN cord-335975-m6lkrehi 1059 19 on on IN cord-335975-m6lkrehi 1059 20 the the DT cord-335975-m6lkrehi 1059 21 risk risk NN cord-335975-m6lkrehi 1059 22 of of IN cord-335975-m6lkrehi 1059 23 false- false- NN cord-335975-m6lkrehi 1060 1 Introduction introduction NN cord-335975-m6lkrehi 1060 2 : : : cord-335975-m6lkrehi 1060 3 Opening opening NN cord-335975-m6lkrehi 1060 4 of of IN cord-335975-m6lkrehi 1060 5 the the DT cord-335975-m6lkrehi 1060 6 mitochondrial mitochondrial JJ cord-335975-m6lkrehi 1060 7 permeability permeability NN cord-335975-m6lkrehi 1060 8 transition transition NN cord-335975-m6lkrehi 1060 9 pore pore NN cord-335975-m6lkrehi 1060 10 ( ( -LRB- cord-335975-m6lkrehi 1060 11 PTP PTP NNP cord-335975-m6lkrehi 1060 12 ) ) -RRB- cord-335975-m6lkrehi 1060 13 , , , cord-335975-m6lkrehi 1060 14 triggered trigger VBN cord-335975-m6lkrehi 1060 15 by by IN cord-335975-m6lkrehi 1060 16 Cyclophilin Cyclophilin NNP cord-335975-m6lkrehi 1060 17 - - HYPH cord-335975-m6lkrehi 1060 18 D D NNP cord-335975-m6lkrehi 1060 19 ( ( -LRB- cord-335975-m6lkrehi 1060 20 CypD CypD NNP cord-335975-m6lkrehi 1060 21 ) ) -RRB- cord-335975-m6lkrehi 1060 22 binding bind VBG cord-335975-m6lkrehi 1060 23 under under IN cord-335975-m6lkrehi 1060 24 stress stress NN cord-335975-m6lkrehi 1060 25 conditions condition NNS cord-335975-m6lkrehi 1060 26 , , , cord-335975-m6lkrehi 1060 27 plays play VBZ cord-335975-m6lkrehi 1060 28 a a DT cord-335975-m6lkrehi 1060 29 key key JJ cord-335975-m6lkrehi 1060 30 role role NN cord-335975-m6lkrehi 1060 31 in in IN cord-335975-m6lkrehi 1060 32 ischemia ischemia NN cord-335975-m6lkrehi 1060 33 - - HYPH cord-335975-m6lkrehi 1060 34 reperfusion reperfusion NN cord-335975-m6lkrehi 1060 35 injury injury NN cord-335975-m6lkrehi 1060 36 . . . cord-335975-m6lkrehi 1061 1 We -PRON- PRP cord-335975-m6lkrehi 1061 2 sought seek VBD cord-335975-m6lkrehi 1061 3 to to TO cord-335975-m6lkrehi 1061 4 determine determine VB cord-335975-m6lkrehi 1061 5 , , , cord-335975-m6lkrehi 1061 6 using use VBG cord-335975-m6lkrehi 1061 7 transgenic transgenic JJ cord-335975-m6lkrehi 1061 8 mice mouse NNS cord-335975-m6lkrehi 1061 9 , , , cord-335975-m6lkrehi 1061 10 whether whether IN cord-335975-m6lkrehi 1061 11 CypD CypD NNP cord-335975-m6lkrehi 1061 12 deletion deletion NN cord-335975-m6lkrehi 1061 13 ( ( -LRB- cord-335975-m6lkrehi 1061 14 CypD CypD NNP cord-335975-m6lkrehi 1061 15 − − NNP cord-335975-m6lkrehi 1061 16 ) ) -RRB- cord-335975-m6lkrehi 1061 17 would would MD cord-335975-m6lkrehi 1061 18 improve improve VB cord-335975-m6lkrehi 1061 19 resuscitability resuscitability NN cord-335975-m6lkrehi 1061 20 and and CC cord-335975-m6lkrehi 1061 21 survival survival NN cord-335975-m6lkrehi 1061 22 after after IN cord-335975-m6lkrehi 1061 23 experimental experimental JJ cord-335975-m6lkrehi 1061 24 cardiac cardiac JJ cord-335975-m6lkrehi 1061 25 arrest arrest NN cord-335975-m6lkrehi 1061 26 ( ( -LRB- cord-335975-m6lkrehi 1061 27 CA CA NNP cord-335975-m6lkrehi 1061 28 ) ) -RRB- cord-335975-m6lkrehi 1061 29 . . . cord-335975-m6lkrehi 1062 1 Additionally additionally RB cord-335975-m6lkrehi 1062 2 , , , cord-335975-m6lkrehi 1062 3 we -PRON- PRP cord-335975-m6lkrehi 1062 4 compared compare VBD cord-335975-m6lkrehi 1062 5 the the DT cord-335975-m6lkrehi 1062 6 protective protective JJ cord-335975-m6lkrehi 1062 7 effects effect NNS cord-335975-m6lkrehi 1062 8 of of IN cord-335975-m6lkrehi 1062 9 CypD CypD NNP cord-335975-m6lkrehi 1062 10 deficiency deficiency NN cord-335975-m6lkrehi 1062 11 with with IN cord-335975-m6lkrehi 1062 12 that that DT cord-335975-m6lkrehi 1062 13 of of IN cord-335975-m6lkrehi 1062 14 targeted target VBN cord-335975-m6lkrehi 1062 15 temperature temperature NN cord-335975-m6lkrehi 1062 16 management management NN cord-335975-m6lkrehi 1062 17 ( ( -LRB- cord-335975-m6lkrehi 1062 18 TTM TTM NNP cord-335975-m6lkrehi 1062 19 ) ) -RRB- cord-335975-m6lkrehi 1062 20 . . . cord-335975-m6lkrehi 1063 1 Patients patient NNS cord-335975-m6lkrehi 1063 2 and and CC cord-335975-m6lkrehi 1063 3 methods method NNS cord-335975-m6lkrehi 1063 4 : : : cord-335975-m6lkrehi 1063 5 Anesthetized anesthetized JJ cord-335975-m6lkrehi 1063 6 mice mouse NNS cord-335975-m6lkrehi 1063 7 underwent undergo VBD cord-335975-m6lkrehi 1063 8 a a DT cord-335975-m6lkrehi 1063 9 5 5 CD cord-335975-m6lkrehi 1063 10 min min NN cord-335975-m6lkrehi 1063 11 asphyxial asphyxial JJ cord-335975-m6lkrehi 1063 12 CA CA NNP cord-335975-m6lkrehi 1063 13 followed follow VBD cord-335975-m6lkrehi 1063 14 by by IN cord-335975-m6lkrehi 1063 15 resuscitation resuscitation NN cord-335975-m6lkrehi 1063 16 ( ( -LRB- cord-335975-m6lkrehi 1063 17 cardiac cardiac JJ cord-335975-m6lkrehi 1063 18 massage massage NN cord-335975-m6lkrehi 1063 19 , , , cord-335975-m6lkrehi 1063 20 resumption resumption NN cord-335975-m6lkrehi 1063 21 of of IN cord-335975-m6lkrehi 1063 22 ventilation ventilation NN cord-335975-m6lkrehi 1063 23 , , , cord-335975-m6lkrehi 1063 24 epinephrine epinephrine NN cord-335975-m6lkrehi 1063 25 ) ) -RRB- cord-335975-m6lkrehi 1063 26 . . . cord-335975-m6lkrehi 1064 1 Four four CD cord-335975-m6lkrehi 1064 2 groups group NNS cord-335975-m6lkrehi 1064 3 of of IN cord-335975-m6lkrehi 1064 4 animals animal NNS cord-335975-m6lkrehi 1064 5 were be VBD cord-335975-m6lkrehi 1064 6 studied study VBN cord-335975-m6lkrehi 1064 7 - - HYPH cord-335975-m6lkrehi 1064 8 Sham Sham NNP cord-335975-m6lkrehi 1064 9 , , , cord-335975-m6lkrehi 1064 10 Control Control NNP cord-335975-m6lkrehi 1064 11 ( ( -LRB- cord-335975-m6lkrehi 1064 12 Ctrl Ctrl NNP cord-335975-m6lkrehi 1064 13 ) ) -RRB- cord-335975-m6lkrehi 1064 14 , , . cord-335975-m6lkrehi 1065 1 CypD CypD NNP cord-335975-m6lkrehi 1065 2 - - HYPH cord-335975-m6lkrehi 1065 3 CA CA NNP cord-335975-m6lkrehi 1065 4 using use VBG cord-335975-m6lkrehi 1065 5 mice mouse NNS cord-335975-m6lkrehi 1065 6 lacking lack VBG cord-335975-m6lkrehi 1065 7 CypD CypD NNP cord-335975-m6lkrehi 1065 8 ( ( -LRB- cord-335975-m6lkrehi 1065 9 knockout knockout NN cord-335975-m6lkrehi 1065 10 mice mouse NNS cord-335975-m6lkrehi 1065 11 ) ) -RRB- cord-335975-m6lkrehi 1065 12 , , , cord-335975-m6lkrehi 1065 13 and and CC cord-335975-m6lkrehi 1065 14 TTM TTM NNP cord-335975-m6lkrehi 1065 15 - - HYPH cord-335975-m6lkrehi 1065 16 CA CA NNP cord-335975-m6lkrehi 1065 17 with with IN cord-335975-m6lkrehi 1065 18 fast fast JJ cord-335975-m6lkrehi 1065 19 hypothermia hypothermia NN cord-335975-m6lkrehi 1065 20 induced induce VBN cord-335975-m6lkrehi 1065 21 by by IN cord-335975-m6lkrehi 1065 22 external external JJ cord-335975-m6lkrehi 1065 23 cooling cooling NN cord-335975-m6lkrehi 1065 24 at at IN cord-335975-m6lkrehi 1065 25 reperfusion reperfusion NN cord-335975-m6lkrehi 1065 26 ( ( -LRB- cord-335975-m6lkrehi 1065 27 33 33 CD cord-335975-m6lkrehi 1065 28 ° ° NN cord-335975-m6lkrehi 1065 29 C c NN cord-335975-m6lkrehi 1065 30 for for IN cord-335975-m6lkrehi 1065 31 1 1 CD cord-335975-m6lkrehi 1065 32 h h NN cord-335975-m6lkrehi 1065 33 ) ) -RRB- cord-335975-m6lkrehi 1065 34 . . . cord-335975-m6lkrehi 1066 1 Two two CD cord-335975-m6lkrehi 1066 2 hours hour NNS cord-335975-m6lkrehi 1066 3 after after IN cord-335975-m6lkrehi 1066 4 CA CA NNP cord-335975-m6lkrehi 1066 5 , , , cord-335975-m6lkrehi 1066 6 the the DT cord-335975-m6lkrehi 1066 7 following follow VBG cord-335975-m6lkrehi 1066 8 measurements measurement NNS cord-335975-m6lkrehi 1066 9 were be VBD cord-335975-m6lkrehi 1066 10 carried carry VBN cord-335975-m6lkrehi 1066 11 out out RP cord-335975-m6lkrehi 1066 12 ( ( -LRB- cord-335975-m6lkrehi 1066 13 n n NN cord-335975-m6lkrehi 1066 14 = = SYM cord-335975-m6lkrehi 1066 15 6 6 CD cord-335975-m6lkrehi 1066 16 - - SYM cord-335975-m6lkrehi 1066 17 9 9 CD cord-335975-m6lkrehi 1066 18 group)-echocardiography group)-echocardiography NNP cord-335975-m6lkrehi 1066 19 , , , cord-335975-m6lkrehi 1066 20 cellular cellular JJ cord-335975-m6lkrehi 1066 21 damage damage NN cord-335975-m6lkrehi 1066 22 markers marker NNS cord-335975-m6lkrehi 1066 23 ( ( -LRB- cord-335975-m6lkrehi 1066 24 including include VBG cord-335975-m6lkrehi 1066 25 S100B s100b JJ cord-335975-m6lkrehi 1066 26 protein protein NN cord-335975-m6lkrehi 1066 27 and and CC cord-335975-m6lkrehi 1066 28 troponin troponin JJ cord-335975-m6lkrehi 1066 29 Ic Ic NNP cord-335975-m6lkrehi 1066 30 ) ) -RRB- cord-335975-m6lkrehi 1066 31 and and CC cord-335975-m6lkrehi 1066 32 mPTP mptp JJ cord-335975-m6lkrehi 1066 33 opening opening NN cord-335975-m6lkrehi 1066 34 in in IN cord-335975-m6lkrehi 1066 35 mitochondria mitochondrion NNS cord-335975-m6lkrehi 1066 36 isolated isolate VBN cord-335975-m6lkrehi 1066 37 from from IN cord-335975-m6lkrehi 1066 38 brain brain NN cord-335975-m6lkrehi 1066 39 and and CC cord-335975-m6lkrehi 1066 40 heart heart NN cord-335975-m6lkrehi 1066 41 . . . cord-335975-m6lkrehi 1067 1 Additional additional JJ cord-335975-m6lkrehi 1067 2 mice mouse NNS cord-335975-m6lkrehi 1067 3 ( ( -LRB- cord-335975-m6lkrehi 1067 4 n n NN cord-335975-m6lkrehi 1067 5 = = SYM cord-335975-m6lkrehi 1067 6 7 7 CD cord-335975-m6lkrehi 1067 7 - - SYM cord-335975-m6lkrehi 1067 8 12 12 CD cord-335975-m6lkrehi 1067 9 group group NN cord-335975-m6lkrehi 1067 10 ) ) -RRB- cord-335975-m6lkrehi 1067 11 were be VBD cord-335975-m6lkrehi 1067 12 included include VBN cord-335975-m6lkrehi 1067 13 in in IN cord-335975-m6lkrehi 1067 14 the the DT cord-335975-m6lkrehi 1067 15 same same JJ cord-335975-m6lkrehi 1067 16 4 4 CD cord-335975-m6lkrehi 1067 17 groups group NNS cord-335975-m6lkrehi 1067 18 for for IN cord-335975-m6lkrehi 1067 19 survival survival NN cord-335975-m6lkrehi 1067 20 follow follow NN cord-335975-m6lkrehi 1067 21 - - HYPH cord-335975-m6lkrehi 1067 22 up up NN cord-335975-m6lkrehi 1067 23 ( ( -LRB- cord-335975-m6lkrehi 1067 24 24 24 CD cord-335975-m6lkrehi 1067 25 h h NN cord-335975-m6lkrehi 1067 26 and and CC cord-335975-m6lkrehi 1067 27 7 7 CD cord-335975-m6lkrehi 1067 28 days day NNS cord-335975-m6lkrehi 1067 29 ) ) -RRB- cord-335975-m6lkrehi 1067 30 . . . cord-335975-m6lkrehi 1068 1 Results result NNS cord-335975-m6lkrehi 1068 2 : : : cord-335975-m6lkrehi 1069 1 Characteristics characteristic NNS cord-335975-m6lkrehi 1069 2 of of IN cord-335975-m6lkrehi 1069 3 CA CA NNP cord-335975-m6lkrehi 1069 4 were be VBD cord-335975-m6lkrehi 1069 5 similar similar JJ cord-335975-m6lkrehi 1069 6 among among IN cord-335975-m6lkrehi 1069 7 groups group NNS cord-335975-m6lkrehi 1069 8 . . . cord-335975-m6lkrehi 1070 1 Rate rate NN cord-335975-m6lkrehi 1070 2 of of IN cord-335975-m6lkrehi 1070 3 restoration restoration NN cord-335975-m6lkrehi 1070 4 of of IN cord-335975-m6lkrehi 1070 5 spontaneous spontaneous JJ cord-335975-m6lkrehi 1070 6 circulation circulation NN cord-335975-m6lkrehi 1070 7 ( ( -LRB- cord-335975-m6lkrehi 1070 8 ROSC ROSC NNP cord-335975-m6lkrehi 1070 9 ) ) -RRB- cord-335975-m6lkrehi 1070 10 was be VBD cord-335975-m6lkrehi 1070 11 significantly significantly RB cord-335975-m6lkrehi 1070 12 higher high JJR cord-335975-m6lkrehi 1070 13 in in IN cord-335975-m6lkrehi 1070 14 CypD CypD NNP cord-335975-m6lkrehi 1070 15 - - HYPH cord-335975-m6lkrehi 1070 16 and and CC cord-335975-m6lkrehi 1070 17 TTM TTM NNP cord-335975-m6lkrehi 1070 18 groups group NNS cord-335975-m6lkrehi 1070 19 compared compare VBN cord-335975-m6lkrehi 1070 20 to to IN cord-335975-m6lkrehi 1070 21 controls control NNS cord-335975-m6lkrehi 1070 22 ( ( -LRB- cord-335975-m6lkrehi 1070 23 p p NN cord-335975-m6lkrehi 1070 24 < < XX cord-335975-m6lkrehi 1070 25 0.05 0.05 CD cord-335975-m6lkrehi 1070 26 ) ) -RRB- cord-335975-m6lkrehi 1070 27 . . . cord-335975-m6lkrehi 1071 1 Time time NN cord-335975-m6lkrehi 1071 2 to to IN cord-335975-m6lkrehi 1071 3 ROSC ROSC NNP cord-335975-m6lkrehi 1071 4 was be VBD cord-335975-m6lkrehi 1071 5 shorter short JJR cord-335975-m6lkrehi 1071 6 in in IN cord-335975-m6lkrehi 1071 7 CypD CypD NNP cord-335975-m6lkrehi 1071 8 - - HYPH cord-335975-m6lkrehi 1071 9 versus versus IN cord-335975-m6lkrehi 1071 10 TTM TTM NNP cord-335975-m6lkrehi 1071 11 and and CC cord-335975-m6lkrehi 1071 12 Ctrl ctrl NN cord-335975-m6lkrehi 1071 13 ( ( -LRB- cord-335975-m6lkrehi 1071 14 p p NN cord-335975-m6lkrehi 1071 15 < < XX cord-335975-m6lkrehi 1071 16 0.05 0.05 CD cord-335975-m6lkrehi 1071 17 ) ) -RRB- cord-335975-m6lkrehi 1071 18 . . . cord-335975-m6lkrehi 1072 1 Genetic genetic JJ cord-335975-m6lkrehi 1072 2 loss loss NN cord-335975-m6lkrehi 1072 3 of of IN cord-335975-m6lkrehi 1072 4 CypD CypD NNP cord-335975-m6lkrehi 1072 5 and and CC cord-335975-m6lkrehi 1072 6 TTM TTM NNP cord-335975-m6lkrehi 1072 7 prevented prevent VBD cord-335975-m6lkrehi 1072 8 to to IN cord-335975-m6lkrehi 1072 9 a a DT cord-335975-m6lkrehi 1072 10 similar similar JJ cord-335975-m6lkrehi 1072 11 extent extent NN cord-335975-m6lkrehi 1072 12 CA ca NN cord-335975-m6lkrehi 1072 13 - - HYPH cord-335975-m6lkrehi 1072 14 induced induce VBN cord-335975-m6lkrehi 1072 15 myocardial myocardial JJ cord-335975-m6lkrehi 1072 16 dysfunction dysfunction NN cord-335975-m6lkrehi 1072 17 , , , cord-335975-m6lkrehi 1072 18 increase increase VB cord-335975-m6lkrehi 1072 19 in in IN cord-335975-m6lkrehi 1072 20 blood blood NN cord-335975-m6lkrehi 1072 21 levels level NNS cord-335975-m6lkrehi 1072 22 of of IN cord-335975-m6lkrehi 1072 23 both both DT cord-335975-m6lkrehi 1072 24 S100B s100b JJ cord-335975-m6lkrehi 1072 25 protein protein NN cord-335975-m6lkrehi 1072 26 and and CC cord-335975-m6lkrehi 1072 27 troponin troponin JJ cord-335975-m6lkrehi 1072 28 Ic Ic NNP cord-335975-m6lkrehi 1072 29 ( ( -LRB- cord-335975-m6lkrehi 1072 30 p p NN cord-335975-m6lkrehi 1072 31 < < XX cord-335975-m6lkrehi 1072 32 0.05 0.05 CD cord-335975-m6lkrehi 1072 33 versus versus IN cord-335975-m6lkrehi 1072 34 Ctrl ctrl NN cord-335975-m6lkrehi 1072 35 ) ) -RRB- cord-335975-m6lkrehi 1072 36 . . . cord-335975-m6lkrehi 1073 1 CA CA NNP cord-335975-m6lkrehi 1073 2 resulted result VBD cord-335975-m6lkrehi 1073 3 in in IN cord-335975-m6lkrehi 1073 4 a a DT cord-335975-m6lkrehi 1073 5 significant significant JJ cord-335975-m6lkrehi 1073 6 increase increase NN cord-335975-m6lkrehi 1073 7 in in IN cord-335975-m6lkrehi 1073 8 PTP PTP NNP cord-335975-m6lkrehi 1073 9 opening opening NN cord-335975-m6lkrehi 1073 10 only only RB cord-335975-m6lkrehi 1073 11 in in IN cord-335975-m6lkrehi 1073 12 mitochondria mitochondrion NNS cord-335975-m6lkrehi 1073 13 isolated isolate VBN cord-335975-m6lkrehi 1073 14 from from IN cord-335975-m6lkrehi 1073 15 brain brain NN cord-335975-m6lkrehi 1073 16 ( ( -LRB- cord-335975-m6lkrehi 1073 17 p p NN cord-335975-m6lkrehi 1073 18 < < XX cord-335975-m6lkrehi 1073 19 0.05 0.05 CD cord-335975-m6lkrehi 1073 20 versus versus IN cord-335975-m6lkrehi 1073 21 Sham Sham NNP cord-335975-m6lkrehi 1073 22 ) ) -RRB- cord-335975-m6lkrehi 1073 23 . . . cord-335975-m6lkrehi 1074 1 CypD CypD NNS cord-335975-m6lkrehi 1074 2 deletion deletion NN cord-335975-m6lkrehi 1074 3 as as RB cord-335975-m6lkrehi 1074 4 well well RB cord-335975-m6lkrehi 1074 5 as as IN cord-335975-m6lkrehi 1074 6 TTM TTM NNP cord-335975-m6lkrehi 1074 7 limited limited JJ cord-335975-m6lkrehi 1074 8 CA CA NNP cord-335975-m6lkrehi 1074 9 - - HYPH cord-335975-m6lkrehi 1074 10 induced induce VBN cord-335975-m6lkrehi 1074 11 PTP PTP NNP cord-335975-m6lkrehi 1074 12 opening opening NN cord-335975-m6lkrehi 1074 13 in in IN cord-335975-m6lkrehi 1074 14 brain brain NN cord-335975-m6lkrehi 1074 15 ( ( -LRB- cord-335975-m6lkrehi 1074 16 p p NN cord-335975-m6lkrehi 1074 17 < < XX cord-335975-m6lkrehi 1074 18 0.05 0.05 CD cord-335975-m6lkrehi 1074 19 versus versus IN cord-335975-m6lkrehi 1074 20 Ctrl ctrl NN cord-335975-m6lkrehi 1074 21 ) ) -RRB- cord-335975-m6lkrehi 1074 22 . . . cord-335975-m6lkrehi 1075 1 Short short JJ cord-335975-m6lkrehi 1075 2 - - HYPH cord-335975-m6lkrehi 1075 3 term term NN cord-335975-m6lkrehi 1075 4 survival survival NN cord-335975-m6lkrehi 1075 5 ( ( -LRB- cord-335975-m6lkrehi 1075 6 24 24 CD cord-335975-m6lkrehi 1075 7 h h NN cord-335975-m6lkrehi 1075 8 ) ) -RRB- cord-335975-m6lkrehi 1075 9 was be VBD cord-335975-m6lkrehi 1075 10 significantly significantly RB cord-335975-m6lkrehi 1075 11 improved improve VBN cord-335975-m6lkrehi 1075 12 in in IN cord-335975-m6lkrehi 1075 13 the the DT cord-335975-m6lkrehi 1075 14 CypD CypD NNP cord-335975-m6lkrehi 1075 15 - - HYPH cord-335975-m6lkrehi 1075 16 and and CC cord-335975-m6lkrehi 1075 17 TTM TTM NNP cord-335975-m6lkrehi 1075 18 groups group NNS cord-335975-m6lkrehi 1075 19 when when WRB cord-335975-m6lkrehi 1075 20 compared compare VBN cord-335975-m6lkrehi 1075 21 to to IN cord-335975-m6lkrehi 1075 22 controls control NNS cord-335975-m6lkrehi 1075 23 ( ( -LRB- cord-335975-m6lkrehi 1075 24 p p NN cord-335975-m6lkrehi 1075 25 < < XX cord-335975-m6lkrehi 1075 26 0.05 0.05 CD cord-335975-m6lkrehi 1075 27 ) ) -RRB- cord-335975-m6lkrehi 1075 28 . . . cord-335975-m6lkrehi 1076 1 However however RB cord-335975-m6lkrehi 1076 2 , , , cord-335975-m6lkrehi 1076 3 only only RB cord-335975-m6lkrehi 1076 4 therapeutic therapeutic JJ cord-335975-m6lkrehi 1076 5 hypothermia hypothermia NN cord-335975-m6lkrehi 1076 6 improved improve VBD cord-335975-m6lkrehi 1076 7 survival survival NN cord-335975-m6lkrehi 1076 8 at at IN cord-335975-m6lkrehi 1076 9 day day NN cord-335975-m6lkrehi 1076 10 7 7 CD cord-335975-m6lkrehi 1076 11 ( ( -LRB- cord-335975-m6lkrehi 1076 12 p p NN cord-335975-m6lkrehi 1076 13 < < XX cord-335975-m6lkrehi 1076 14 0.05 0.05 CD cord-335975-m6lkrehi 1076 15 versus versus IN cord-335975-m6lkrehi 1076 16 Ctrl ctrl NN cord-335975-m6lkrehi 1076 17 ) ) -RRB- cord-335975-m6lkrehi 1076 18 . . . cord-335975-m6lkrehi 1077 1 In in IN cord-335975-m6lkrehi 1077 2 our -PRON- PRP$ cord-335975-m6lkrehi 1077 3 murine murine JJ cord-335975-m6lkrehi 1077 4 CA CA NNP cord-335975-m6lkrehi 1077 5 model model NN cord-335975-m6lkrehi 1077 6 , , , cord-335975-m6lkrehi 1077 7 genetic genetic JJ cord-335975-m6lkrehi 1077 8 loss loss NN cord-335975-m6lkrehi 1077 9 of of IN cord-335975-m6lkrehi 1077 10 CypD CypD NNP cord-335975-m6lkrehi 1077 11 increased increase VBN cord-335975-m6lkrehi 1077 12 resuscitability resuscitability NN cord-335975-m6lkrehi 1077 13 and and CC cord-335975-m6lkrehi 1077 14 short short JJ cord-335975-m6lkrehi 1077 15 - - HYPH cord-335975-m6lkrehi 1077 16 term term NN cord-335975-m6lkrehi 1077 17 survival survival NN cord-335975-m6lkrehi 1077 18 but but CC cord-335975-m6lkrehi 1077 19 , , , cord-335975-m6lkrehi 1077 20 unlike unlike IN cord-335975-m6lkrehi 1077 21 therapeutic therapeutic JJ cord-335975-m6lkrehi 1077 22 hypothermia hypothermia NN cord-335975-m6lkrehi 1077 23 , , , cord-335975-m6lkrehi 1077 24 failed fail VBD cord-335975-m6lkrehi 1077 25 to to TO cord-335975-m6lkrehi 1077 26 improve improve VB cord-335975-m6lkrehi 1077 27 7-day 7-day JJ cord-335975-m6lkrehi 1077 28 survival survival NN cord-335975-m6lkrehi 1077 29 . . . cord-335975-m6lkrehi 1078 1 Introduction introduction NN cord-335975-m6lkrehi 1078 2 : : : cord-335975-m6lkrehi 1079 1 Early early JJ cord-335975-m6lkrehi 1079 2 prediction prediction NN cord-335975-m6lkrehi 1079 3 of of IN cord-335975-m6lkrehi 1079 4 neurological neurological JJ cord-335975-m6lkrehi 1079 5 outcome outcome NN cord-335975-m6lkrehi 1079 6 of of IN cord-335975-m6lkrehi 1079 7 post post JJ cord-335975-m6lkrehi 1079 8 - - JJ cord-335975-m6lkrehi 1079 9 anoxic anoxic JJ cord-335975-m6lkrehi 1079 10 comatose comatose JJ cord-335975-m6lkrehi 1079 11 patients patient NNS cord-335975-m6lkrehi 1079 12 after after IN cord-335975-m6lkrehi 1079 13 cardiac cardiac JJ cord-335975-m6lkrehi 1079 14 arrest arrest NN cord-335975-m6lkrehi 1079 15 ( ( -LRB- cord-335975-m6lkrehi 1079 16 CA CA NNP cord-335975-m6lkrehi 1079 17 ) ) -RRB- cord-335975-m6lkrehi 1079 18 is be VBZ cord-335975-m6lkrehi 1079 19 challenging challenging JJ cord-335975-m6lkrehi 1079 20 . . . cord-335975-m6lkrehi 1080 1 Prognosis prognosis NN cord-335975-m6lkrehi 1080 2 of of IN cord-335975-m6lkrehi 1080 3 comatose comatose JJ cord-335975-m6lkrehi 1080 4 patient patient NN cord-335975-m6lkrehi 1080 5 relies rely VBZ cord-335975-m6lkrehi 1080 6 on on IN cord-335975-m6lkrehi 1080 7 multimodal multimodal NN cord-335975-m6lkrehi 1080 8 testing testing NN cord-335975-m6lkrehi 1080 9 - - HYPH cord-335975-m6lkrehi 1080 10 clinical clinical JJ cord-335975-m6lkrehi 1080 11 examination examination NN cord-335975-m6lkrehi 1080 12 , , , cord-335975-m6lkrehi 1080 13 electrophysiological electrophysiological JJ cord-335975-m6lkrehi 1080 14 testing testing NN cord-335975-m6lkrehi 1080 15 and and CC cord-335975-m6lkrehi 1080 16 structural structural JJ cord-335975-m6lkrehi 1080 17 neuroimaging neuroimaging NN cord-335975-m6lkrehi 1080 18 ( ( -LRB- cord-335975-m6lkrehi 1080 19 mainly mainly RB cord-335975-m6lkrehi 1080 20 diffusion diffusion NN cord-335975-m6lkrehi 1080 21 MRI MRI NNP cord-335975-m6lkrehi 1080 22 ) ) -RRB- cord-335975-m6lkrehi 1080 23 . . . cord-335975-m6lkrehi 1081 1 This this DT cord-335975-m6lkrehi 1081 2 prognostication prognostication NN cord-335975-m6lkrehi 1081 3 is be VBZ cord-335975-m6lkrehi 1081 4 accurate accurate JJ cord-335975-m6lkrehi 1081 5 for for IN cord-335975-m6lkrehi 1081 6 predicting predict VBG cord-335975-m6lkrehi 1081 7 poor poor JJ cord-335975-m6lkrehi 1081 8 outcome outcome NN cord-335975-m6lkrehi 1081 9 ( ( -LRB- cord-335975-m6lkrehi 1081 10 i.e. i.e. FW cord-335975-m6lkrehi 1081 11 death death NN cord-335975-m6lkrehi 1081 12 ) ) -RRB- cord-335975-m6lkrehi 1081 13 but but CC cord-335975-m6lkrehi 1081 14 not not RB cord-335975-m6lkrehi 1081 15 sensitive sensitive JJ cord-335975-m6lkrehi 1081 16 for for IN cord-335975-m6lkrehi 1081 17 identifying identify VBG cord-335975-m6lkrehi 1081 18 patients patient NNS cord-335975-m6lkrehi 1081 19 with with IN cord-335975-m6lkrehi 1081 20 good good JJ cord-335975-m6lkrehi 1081 21 outcome outcome NN cord-335975-m6lkrehi 1081 22 ( ( -LRB- cord-335975-m6lkrehi 1081 23 i.e. i.e. FW cord-335975-m6lkrehi 1081 24 consciousness consciousness NN cord-335975-m6lkrehi 1081 25 recovery recovery NN cord-335975-m6lkrehi 1081 26 ) ) -RRB- cord-335975-m6lkrehi 1081 27 . . . cord-335975-m6lkrehi 1082 1 Resting rest VBG cord-335975-m6lkrehi 1082 2 state state NN cord-335975-m6lkrehi 1082 3 functional functional JJ cord-335975-m6lkrehi 1082 4 MRI MRI NNP cord-335975-m6lkrehi 1082 5 ( ( -LRB- cord-335975-m6lkrehi 1082 6 rs rs NNP cord-335975-m6lkrehi 1082 7 - - HYPH cord-335975-m6lkrehi 1082 8 fMRI fMRI NNP cord-335975-m6lkrehi 1082 9 ) ) -RRB- cord-335975-m6lkrehi 1082 10 is be VBZ cord-335975-m6lkrehi 1082 11 a a DT cord-335975-m6lkrehi 1082 12 powerful powerful JJ cord-335975-m6lkrehi 1082 13 tool tool NN cord-335975-m6lkrehi 1082 14 for for IN cord-335975-m6lkrehi 1082 15 mapping map VBG cord-335975-m6lkrehi 1082 16 functional functional JJ cord-335975-m6lkrehi 1082 17 connectivity connectivity NN cord-335975-m6lkrehi 1082 18 , , , cord-335975-m6lkrehi 1082 19 especially especially RB cord-335975-m6lkrehi 1082 20 in in IN cord-335975-m6lkrehi 1082 21 patients patient NNS cord-335975-m6lkrehi 1082 22 with with IN cord-335975-m6lkrehi 1082 23 low low JJ cord-335975-m6lkrehi 1082 24 collaboration collaboration NN cord-335975-m6lkrehi 1082 25 . . . cord-335975-m6lkrehi 1083 1 Several several JJ cord-335975-m6lkrehi 1083 2 studies study NNS cord-335975-m6lkrehi 1083 3 showed show VBD cord-335975-m6lkrehi 1083 4 that that IN cord-335975-m6lkrehi 1083 5 rs rs NN cord-335975-m6lkrehi 1083 6 - - HYPH cord-335975-m6lkrehi 1083 7 fMRI fMRI NNP cord-335975-m6lkrehi 1083 8 can can MD cord-335975-m6lkrehi 1083 9 differentiate differentiate VB cord-335975-m6lkrehi 1083 10 states state NNS cord-335975-m6lkrehi 1083 11 of of IN cord-335975-m6lkrehi 1083 12 consciousness consciousness NN cord-335975-m6lkrehi 1083 13 in in IN cord-335975-m6lkrehi 1083 14 chronically chronically RB cord-335975-m6lkrehi 1083 15 brain brain NN cord-335975-m6lkrehi 1083 16 - - HYPH cord-335975-m6lkrehi 1083 17 damaged damage VBN cord-335975-m6lkrehi 1083 18 patients patient NNS cord-335975-m6lkrehi 1083 19 . . . cord-335975-m6lkrehi 1084 1 A a DT cord-335975-m6lkrehi 1084 2 recent recent JJ cord-335975-m6lkrehi 1084 3 study study NN cord-335975-m6lkrehi 1084 4 also also RB cord-335975-m6lkrehi 1084 5 showed show VBD cord-335975-m6lkrehi 1084 6 that that IN cord-335975-m6lkrehi 1084 7 functional functional JJ cord-335975-m6lkrehi 1084 8 neuroimaging neuroimaging NN cord-335975-m6lkrehi 1084 9 can can MD cord-335975-m6lkrehi 1084 10 early early RB cord-335975-m6lkrehi 1084 11 detect detect VB cord-335975-m6lkrehi 1084 12 signs sign NNS cord-335975-m6lkrehi 1084 13 of of IN cord-335975-m6lkrehi 1084 14 consciousness consciousness NN cord-335975-m6lkrehi 1084 15 in in IN cord-335975-m6lkrehi 1084 16 patient patient NN cord-335975-m6lkrehi 1084 17 with with IN cord-335975-m6lkrehi 1084 18 acute acute JJ cord-335975-m6lkrehi 1084 19 traumatic traumatic JJ cord-335975-m6lkrehi 1084 20 brain brain NN cord-335975-m6lkrehi 1084 21 injury injury NN cord-335975-m6lkrehi 1084 22 . . . cord-335975-m6lkrehi 1085 1 However however RB cord-335975-m6lkrehi 1085 2 , , , cord-335975-m6lkrehi 1085 3 rs rs NNP cord-335975-m6lkrehi 1085 4 - - HYPH cord-335975-m6lkrehi 1085 5 fMRI fMRI NNP cord-335975-m6lkrehi 1085 6 has have VBZ cord-335975-m6lkrehi 1085 7 not not RB cord-335975-m6lkrehi 1085 8 been be VBN cord-335975-m6lkrehi 1085 9 assessed assess VBN cord-335975-m6lkrehi 1085 10 for for IN cord-335975-m6lkrehi 1085 11 the the DT cord-335975-m6lkrehi 1085 12 early early JJ cord-335975-m6lkrehi 1085 13 prognostication prognostication NN cord-335975-m6lkrehi 1085 14 of of IN cord-335975-m6lkrehi 1085 15 post post JJ cord-335975-m6lkrehi 1085 16 - - JJ cord-335975-m6lkrehi 1085 17 anoxic anoxic JJ cord-335975-m6lkrehi 1085 18 comatose comatose JJ cord-335975-m6lkrehi 1085 19 patient patient NN cord-335975-m6lkrehi 1085 20 . . . cord-335975-m6lkrehi 1086 1 We -PRON- PRP cord-335975-m6lkrehi 1086 2 assessed assess VBD cord-335975-m6lkrehi 1086 3 whole whole JJ cord-335975-m6lkrehi 1086 4 - - HYPH cord-335975-m6lkrehi 1086 5 brain brain NN cord-335975-m6lkrehi 1086 6 function function NN cord-335975-m6lkrehi 1086 7 connectivity connectivity NN cord-335975-m6lkrehi 1086 8 ( ( -LRB- cord-335975-m6lkrehi 1086 9 FC FC NNP cord-335975-m6lkrehi 1086 10 ) ) -RRB- cord-335975-m6lkrehi 1086 11 of of IN cord-335975-m6lkrehi 1086 12 17 17 CD cord-335975-m6lkrehi 1086 13 post post JJ cord-335975-m6lkrehi 1086 14 - - JJ cord-335975-m6lkrehi 1086 15 anoxic anoxic JJ cord-335975-m6lkrehi 1086 16 comatose comatose JJ cord-335975-m6lkrehi 1086 17 patients patient NNS cord-335975-m6lkrehi 1086 18 early early RB cord-335975-m6lkrehi 1086 19 after after IN cord-335975-m6lkrehi 1086 20 CA CA NNP cord-335975-m6lkrehi 1086 21 using use VBG cord-335975-m6lkrehi 1086 22 rs rs NNP cord-335975-m6lkrehi 1086 23 - - HYPH cord-335975-m6lkrehi 1086 24 fMRI fMRI NNP cord-335975-m6lkrehi 1086 25 . . . cord-335975-m6lkrehi 1087 1 Nine nine CD cord-335975-m6lkrehi 1087 2 patients patient NNS cord-335975-m6lkrehi 1087 3 ultimately ultimately RB cord-335975-m6lkrehi 1087 4 recovered recover VBD cord-335975-m6lkrehi 1087 5 consciousness consciousness NN cord-335975-m6lkrehi 1087 6 ( ( -LRB- cord-335975-m6lkrehi 1087 7 good good JJ cord-335975-m6lkrehi 1087 8 outcome outcome NN cord-335975-m6lkrehi 1087 9 ) ) -RRB- cord-335975-m6lkrehi 1087 10 while while IN cord-335975-m6lkrehi 1087 11 eight eight CD cord-335975-m6lkrehi 1087 12 died die VBD cord-335975-m6lkrehi 1087 13 ( ( -LRB- cord-335975-m6lkrehi 1087 14 poor poor JJ cord-335975-m6lkrehi 1087 15 outcome outcome NN cord-335975-m6lkrehi 1087 16 ) ) -RRB- cord-335975-m6lkrehi 1087 17 . . . cord-335975-m6lkrehi 1088 1 We -PRON- PRP cord-335975-m6lkrehi 1088 2 estimated estimate VBD cord-335975-m6lkrehi 1088 3 FC FC NNP cord-335975-m6lkrehi 1088 4 for for IN cord-335975-m6lkrehi 1088 5 each each DT cord-335975-m6lkrehi 1088 6 patient patient NN cord-335975-m6lkrehi 1088 7 following follow VBG cord-335975-m6lkrehi 1088 8 a a DT cord-335975-m6lkrehi 1088 9 procedure procedure NN cord-335975-m6lkrehi 1088 10 previously previously RB cord-335975-m6lkrehi 1088 11 described describe VBN cord-335975-m6lkrehi 1088 12 . . . cord-335975-m6lkrehi 1089 1 We -PRON- PRP cord-335975-m6lkrehi 1089 2 statistically statistically RB cord-335975-m6lkrehi 1089 3 compared compare VBD cord-335975-m6lkrehi 1089 4 whole whole JJ cord-335975-m6lkrehi 1089 5 - - HYPH cord-335975-m6lkrehi 1089 6 brain brain NN cord-335975-m6lkrehi 1089 7 FC fc NN cord-335975-m6lkrehi 1089 8 between between IN cord-335975-m6lkrehi 1089 9 good good JJ cord-335975-m6lkrehi 1089 10 and and CC cord-335975-m6lkrehi 1089 11 poor poor JJ cord-335975-m6lkrehi 1089 12 outcome outcome NN cord-335975-m6lkrehi 1089 13 group group NN cord-335975-m6lkrehi 1089 14 , , , cord-335975-m6lkrehi 1089 15 to to TO cord-335975-m6lkrehi 1089 16 assess assess VB cord-335975-m6lkrehi 1089 17 which which WDT cord-335975-m6lkrehi 1089 18 brain brain NN cord-335975-m6lkrehi 1089 19 connections connection NNS cord-335975-m6lkrehi 1089 20 differed differ VBD cord-335975-m6lkrehi 1089 21 between between IN cord-335975-m6lkrehi 1089 22 them -PRON- PRP cord-335975-m6lkrehi 1089 23 . . . cord-335975-m6lkrehi 1090 1 Then then RB cord-335975-m6lkrehi 1090 2 , , , cord-335975-m6lkrehi 1090 3 we -PRON- PRP cord-335975-m6lkrehi 1090 4 trained train VBD cord-335975-m6lkrehi 1090 5 a a DT cord-335975-m6lkrehi 1090 6 machine machine NN cord-335975-m6lkrehi 1090 7 - - HYPH cord-335975-m6lkrehi 1090 8 learning learn VBG cord-335975-m6lkrehi 1090 9 classifier classifier NN cord-335975-m6lkrehi 1090 10 ( ( -LRB- cord-335975-m6lkrehi 1090 11 a a DT cord-335975-m6lkrehi 1090 12 Support Support NNP cord-335975-m6lkrehi 1090 13 Vector Vector NNP cord-335975-m6lkrehi 1090 14 Machine machine NN cord-335975-m6lkrehi 1090 15 , , , cord-335975-m6lkrehi 1090 16 SVM SVM NNP cord-335975-m6lkrehi 1090 17 ) ) -RRB- cord-335975-m6lkrehi 1090 18 to to TO cord-335975-m6lkrehi 1090 19 automatically automatically RB cord-335975-m6lkrehi 1090 20 predict predict VB cord-335975-m6lkrehi 1090 21 coma coma NN cord-335975-m6lkrehi 1090 22 outcome outcome NN cord-335975-m6lkrehi 1090 23 ( ( -LRB- cord-335975-m6lkrehi 1090 24 good good JJ cord-335975-m6lkrehi 1090 25 poor poor JJ cord-335975-m6lkrehi 1090 26 ) ) -RRB- cord-335975-m6lkrehi 1090 27 based base VBN cord-335975-m6lkrehi 1090 28 on on IN cord-335975-m6lkrehi 1090 29 wholebrain wholebrain NNP cord-335975-m6lkrehi 1090 30 FC FC NNP cord-335975-m6lkrehi 1090 31 of of IN cord-335975-m6lkrehi 1090 32 comatose comatose JJ cord-335975-m6lkrehi 1090 33 patients patient NNS cord-335975-m6lkrehi 1090 34 . . . cord-335975-m6lkrehi 1091 1 Finally finally RB cord-335975-m6lkrehi 1091 2 , , , cord-335975-m6lkrehi 1091 3 we -PRON- PRP cord-335975-m6lkrehi 1091 4 compared compare VBD cord-335975-m6lkrehi 1091 5 this this DT cord-335975-m6lkrehi 1091 6 outcome outcome NN cord-335975-m6lkrehi 1091 7 prognostication prognostication NN cord-335975-m6lkrehi 1091 8 based base VBN cord-335975-m6lkrehi 1091 9 on on IN cord-335975-m6lkrehi 1091 10 functional functional JJ cord-335975-m6lkrehi 1091 11 MRI MRI NNP cord-335975-m6lkrehi 1091 12 to to IN cord-335975-m6lkrehi 1091 13 those those DT cord-335975-m6lkrehi 1091 14 using use VBG cord-335975-m6lkrehi 1091 15 standard standard JJ cord-335975-m6lkrehi 1091 16 structural structural JJ cord-335975-m6lkrehi 1091 17 diffusion diffusion NN cord-335975-m6lkrehi 1091 18 MRI MRI NNP cord-335975-m6lkrehi 1091 19 . . . cord-335975-m6lkrehi 1092 1 Results result NNS cord-335975-m6lkrehi 1092 2 : : : cord-335975-m6lkrehi 1093 1 Good good JJ cord-335975-m6lkrehi 1093 2 and and CC cord-335975-m6lkrehi 1093 3 poor poor JJ cord-335975-m6lkrehi 1093 4 coma coma NN cord-335975-m6lkrehi 1093 5 outcome outcome NN cord-335975-m6lkrehi 1093 6 groups group NNS cord-335975-m6lkrehi 1093 7 were be VBD cord-335975-m6lkrehi 1093 8 similar similar JJ cord-335975-m6lkrehi 1093 9 in in IN cord-335975-m6lkrehi 1093 10 terms term NNS cord-335975-m6lkrehi 1093 11 of of IN cord-335975-m6lkrehi 1093 12 demographics demographic NNS cord-335975-m6lkrehi 1093 13 , , , cord-335975-m6lkrehi 1093 14 except except IN cord-335975-m6lkrehi 1093 15 for for IN cord-335975-m6lkrehi 1093 16 time time NN cord-335975-m6lkrehi 1093 17 to to IN cord-335975-m6lkrehi 1093 18 ROSC ROSC NNP cord-335975-m6lkrehi 1093 19 . . . cord-335975-m6lkrehi 1094 1 Good good JJ cord-335975-m6lkrehi 1094 2 outcome outcome NN cord-335975-m6lkrehi 1094 3 group group NN cord-335975-m6lkrehi 1094 4 showed show VBD cord-335975-m6lkrehi 1094 5 significant significant JJ cord-335975-m6lkrehi 1094 6 increase increase NN cord-335975-m6lkrehi 1094 7 in in IN cord-335975-m6lkrehi 1094 8 whole whole JJ cord-335975-m6lkrehi 1094 9 - - HYPH cord-335975-m6lkrehi 1094 10 brain brain NN cord-335975-m6lkrehi 1094 11 FC fc NN cord-335975-m6lkrehi 1094 12 between between IN cord-335975-m6lkrehi 1094 13 most most JJS cord-335975-m6lkrehi 1094 14 cortical cortical JJ cord-335975-m6lkrehi 1094 15 brain brain NN cord-335975-m6lkrehi 1094 16 regions region NNS cord-335975-m6lkrehi 1094 17 + + CC cord-335975-m6lkrehi 1094 18 with with IN cord-335975-m6lkrehi 1094 19 the the DT cord-335975-m6lkrehi 1094 20 strongest strong JJS cord-335975-m6lkrehi 1094 21 changes change NNS cord-335975-m6lkrehi 1094 22 occurring occur VBG cord-335975-m6lkrehi 1094 23 within within IN cord-335975-m6lkrehi 1094 24 and and CC cord-335975-m6lkrehi 1094 25 between between IN cord-335975-m6lkrehi 1094 26 occipital occipital JJ cord-335975-m6lkrehi 1094 27 and and CC cord-335975-m6lkrehi 1094 28 parietal parietal JJ cord-335975-m6lkrehi 1094 29 , , , cord-335975-m6lkrehi 1094 30 temporal temporal JJ cord-335975-m6lkrehi 1094 31 and and CC cord-335975-m6lkrehi 1094 32 frontal frontal JJ cord-335975-m6lkrehi 1094 33 regions region NNS cord-335975-m6lkrehi 1094 34 ( ( -LRB- cord-335975-m6lkrehi 1094 35 Fig Fig NNP cord-335975-m6lkrehi 1094 36 . . NNP cord-335975-m6lkrehi 1094 37 1 1 CD cord-335975-m6lkrehi 1094 38 ) ) -RRB- cord-335975-m6lkrehi 1094 39 . . . cord-335975-m6lkrehi 1095 1 Using use VBG cord-335975-m6lkrehi 1095 2 whole whole JJ cord-335975-m6lkrehi 1095 3 - - HYPH cord-335975-m6lkrehi 1095 4 brain brain NN cord-335975-m6lkrehi 1095 5 FC fc NN cord-335975-m6lkrehi 1095 6 and and CC cord-335975-m6lkrehi 1095 7 a a DT cord-335975-m6lkrehi 1095 8 SVM SVM NNP cord-335975-m6lkrehi 1095 9 classifier classifier NN cord-335975-m6lkrehi 1095 10 to to TO cord-335975-m6lkrehi 1095 11 predict predict VB cord-335975-m6lkrehi 1095 12 coma coma NN cord-335975-m6lkrehi 1095 13 outcome outcome NN cord-335975-m6lkrehi 1095 14 yielded yield VBD cord-335975-m6lkrehi 1095 15 to to IN cord-335975-m6lkrehi 1095 16 an an DT cord-335975-m6lkrehi 1095 17 overall overall JJ cord-335975-m6lkrehi 1095 18 prediction prediction NN cord-335975-m6lkrehi 1095 19 accuracy accuracy NN cord-335975-m6lkrehi 1095 20 of of IN cord-335975-m6lkrehi 1095 21 94.4%(AUC 94.4%(auc CD cord-335975-m6lkrehi 1095 22 0.94 0.94 CD cord-335975-m6lkrehi 1095 23 ) ) -RRB- cord-335975-m6lkrehi 1095 24 . . . cord-335975-m6lkrehi 1096 1 Interestingly interestingly RB cord-335975-m6lkrehi 1096 2 , , , cord-335975-m6lkrehi 1096 3 automatic automatic JJ cord-335975-m6lkrehi 1096 4 outcome outcome NN cord-335975-m6lkrehi 1096 5 prognostication prognostication NN cord-335975-m6lkrehi 1096 6 using use VBG cord-335975-m6lkrehi 1096 7 functional functional JJ cord-335975-m6lkrehi 1096 8 neuroimaging neuroimaging NN cord-335975-m6lkrehi 1096 9 achieved achieve VBN cord-335975-m6lkrehi 1096 10 better well JJR cord-335975-m6lkrehi 1096 11 results result NNS cord-335975-m6lkrehi 1096 12 that that IN cord-335975-m6lkrehi 1096 13 structural structural JJ cord-335975-m6lkrehi 1096 14 neuroimaging neuroimaging NN cord-335975-m6lkrehi 1096 15 methods method NNS cord-335975-m6lkrehi 1096 16 like like IN cord-335975-m6lkrehi 1096 17 DWI DWI NNP cord-335975-m6lkrehi 1096 18 ( ( -LRB- cord-335975-m6lkrehi 1096 19 accuracy accuracy NN cord-335975-m6lkrehi 1096 20 70.6 70.6 CD cord-335975-m6lkrehi 1096 21 % % NN cord-335975-m6lkrehi 1096 22 ) ) -RRB- cord-335975-m6lkrehi 1096 23 . . . cord-335975-m6lkrehi 1097 1 Conclusion conclusion NN cord-335975-m6lkrehi 1097 2 : : : cord-335975-m6lkrehi 1097 3 We -PRON- PRP cord-335975-m6lkrehi 1097 4 used use VBD cord-335975-m6lkrehi 1097 5 rs rs NN cord-335975-m6lkrehi 1097 6 - - HYPH cord-335975-m6lkrehi 1097 7 fMRI fMRI NNP cord-335975-m6lkrehi 1097 8 to to TO cord-335975-m6lkrehi 1097 9 predict predict VB cord-335975-m6lkrehi 1097 10 coma coma NN cord-335975-m6lkrehi 1097 11 outcome outcome NN cord-335975-m6lkrehi 1097 12 in in IN cord-335975-m6lkrehi 1097 13 a a DT cord-335975-m6lkrehi 1097 14 cohort cohort NN cord-335975-m6lkrehi 1097 15 of of IN cord-335975-m6lkrehi 1097 16 post post JJ cord-335975-m6lkrehi 1097 17 - - JJ cord-335975-m6lkrehi 1097 18 anoxic anoxic JJ cord-335975-m6lkrehi 1097 19 comatose comatose JJ cord-335975-m6lkrehi 1097 20 patients patient NNS cord-335975-m6lkrehi 1097 21 early early RB cord-335975-m6lkrehi 1097 22 after after IN cord-335975-m6lkrehi 1097 23 CA CA NNP cord-335975-m6lkrehi 1097 24 . . . cord-335975-m6lkrehi 1098 1 We -PRON- PRP cord-335975-m6lkrehi 1098 2 deliberately deliberately RB cord-335975-m6lkrehi 1098 3 chose choose VBD cord-335975-m6lkrehi 1098 4 to to TO cord-335975-m6lkrehi 1098 5 include include VB cord-335975-m6lkrehi 1098 6 only only RB cord-335975-m6lkrehi 1098 7 patients patient NNS cord-335975-m6lkrehi 1098 8 with with IN cord-335975-m6lkrehi 1098 9 indeterminate indeterminate JJ cord-335975-m6lkrehi 1098 10 prognosis prognosis NN cord-335975-m6lkrehi 1098 11 after after IN cord-335975-m6lkrehi 1098 12 standard standard JJ cord-335975-m6lkrehi 1098 13 multimodal multimodal NN cord-335975-m6lkrehi 1098 14 testing testing NN cord-335975-m6lkrehi 1098 15 , , , cord-335975-m6lkrehi 1098 16 to to TO cord-335975-m6lkrehi 1098 17 assess assess VB cord-335975-m6lkrehi 1098 18 the the DT cord-335975-m6lkrehi 1098 19 contribution contribution NN cord-335975-m6lkrehi 1098 20 of of IN cord-335975-m6lkrehi 1098 21 rs rs NNP cord-335975-m6lkrehi 1098 22 - - HYPH cord-335975-m6lkrehi 1098 23 fMRI fMRI NNP cord-335975-m6lkrehi 1098 24 in in IN cord-335975-m6lkrehi 1098 25 the the DT cord-335975-m6lkrehi 1098 26 early early JJ cord-335975-m6lkrehi 1098 27 prognostication prognostication NN cord-335975-m6lkrehi 1098 28 of of IN cord-335975-m6lkrehi 1098 29 coma coma NN cord-335975-m6lkrehi 1098 30 outcome outcome NN cord-335975-m6lkrehi 1098 31 . . . cord-335975-m6lkrehi 1099 1 We -PRON- PRP cord-335975-m6lkrehi 1099 2 found find VBD cord-335975-m6lkrehi 1099 3 that that IN cord-335975-m6lkrehi 1099 4 automatic automatic JJ cord-335975-m6lkrehi 1099 5 prediction prediction NN cord-335975-m6lkrehi 1099 6 based base VBN cord-335975-m6lkrehi 1099 7 on on IN cord-335975-m6lkrehi 1099 8 functional functional JJ cord-335975-m6lkrehi 1099 9 neuroimaging neuroimaging NN cord-335975-m6lkrehi 1099 10 yielded yield VBD cord-335975-m6lkrehi 1099 11 much much RB cord-335975-m6lkrehi 1099 12 better well JJR cord-335975-m6lkrehi 1099 13 results result NNS cord-335975-m6lkrehi 1099 14 than than IN cord-335975-m6lkrehi 1099 15 current current JJ cord-335975-m6lkrehi 1099 16 DWI DWI NNP cord-335975-m6lkrehi 1099 17 methods method NNS cord-335975-m6lkrehi 1099 18 , , , cord-335975-m6lkrehi 1099 19 notably notably RB cord-335975-m6lkrehi 1099 20 for for IN cord-335975-m6lkrehi 1099 21 identifying identify VBG cord-335975-m6lkrehi 1099 22 patients patient NNS cord-335975-m6lkrehi 1099 23 who who WP cord-335975-m6lkrehi 1099 24 recovered recover VBD cord-335975-m6lkrehi 1099 25 consciousness consciousness NN cord-335975-m6lkrehi 1099 26 . . . cord-335975-m6lkrehi 1100 1 Outcomes outcome NNS cord-335975-m6lkrehi 1100 2 of of IN cord-335975-m6lkrehi 1100 3 post post JJ cord-335975-m6lkrehi 1100 4 - - JJ cord-335975-m6lkrehi 1100 5 anoxic anoxic JJ cord-335975-m6lkrehi 1100 6 comatose comatose JJ cord-335975-m6lkrehi 1100 7 patients patient NNS cord-335975-m6lkrehi 1100 8 early early RB cord-335975-m6lkrehi 1100 9 after after IN cord-335975-m6lkrehi 1100 10 CA CA NNP cord-335975-m6lkrehi 1100 11 , , , cord-335975-m6lkrehi 1100 12 using use VBG cord-335975-m6lkrehi 1100 13 rs rs NN cord-335975-m6lkrehi 1100 14 - - HYPH cord-335975-m6lkrehi 1100 15 fMRI fMRI NNP cord-335975-m6lkrehi 1100 16 in in IN cord-335975-m6lkrehi 1100 17 RCTs RCTs NNP cord-335975-m6lkrehi 1100 18 comparing compare VBG cord-335975-m6lkrehi 1100 19 treatment treatment NN cord-335975-m6lkrehi 1100 20 of of IN cord-335975-m6lkrehi 1100 21 severe severe JJ cord-335975-m6lkrehi 1100 22 pneumonia pneumonia NN cord-335975-m6lkrehi 1100 23 that that WDT cord-335975-m6lkrehi 1100 24 may may MD cord-335975-m6lkrehi 1100 25 influence influence VB cord-335975-m6lkrehi 1100 26 their -PRON- PRP$ cord-335975-m6lkrehi 1100 27 ability ability NN cord-335975-m6lkrehi 1100 28 to to TO cord-335975-m6lkrehi 1100 29 demonstrate demonstrate VB cord-335975-m6lkrehi 1100 30 differences difference NNS cord-335975-m6lkrehi 1100 31 between between IN cord-335975-m6lkrehi 1100 32 studied study VBN cord-335975-m6lkrehi 1100 33 drugs drug NNS cord-335975-m6lkrehi 1100 34 . . . cord-335975-m6lkrehi 1101 1 Clinical clinical JJ cord-335975-m6lkrehi 1101 2 cure cure NN cord-335975-m6lkrehi 1101 3 was be VBD cord-335975-m6lkrehi 1101 4 the the DT cord-335975-m6lkrehi 1101 5 most most RBS cord-335975-m6lkrehi 1101 6 frequently frequently RB cord-335975-m6lkrehi 1101 7 used use VBN cord-335975-m6lkrehi 1101 8 endpoint endpoint NN cord-335975-m6lkrehi 1101 9 but but CC cord-335975-m6lkrehi 1101 10 its -PRON- PRP$ cord-335975-m6lkrehi 1101 11 definition definition NN cord-335975-m6lkrehi 1101 12 was be VBD cord-335975-m6lkrehi 1101 13 highly highly RB cord-335975-m6lkrehi 1101 14 variable variable JJ cord-335975-m6lkrehi 1101 15 . . . cord-335975-m6lkrehi 1102 1 These these DT cord-335975-m6lkrehi 1102 2 results result NNS cord-335975-m6lkrehi 1102 3 are be VBP cord-335975-m6lkrehi 1102 4 not not RB cord-335975-m6lkrehi 1102 5 surprising surprising JJ cord-335975-m6lkrehi 1102 6 as as RB cord-335975-m6lkrehi 1102 7 far far RB cord-335975-m6lkrehi 1102 8 as as IN cord-335975-m6lkrehi 1102 9 even even RB cord-335975-m6lkrehi 1102 10 guidance guidance NN cord-335975-m6lkrehi 1102 11 from from IN cord-335975-m6lkrehi 1102 12 regulatory regulatory JJ cord-335975-m6lkrehi 1102 13 agencies agency NNS cord-335975-m6lkrehi 1102 14 on on IN cord-335975-m6lkrehi 1102 15 how how WRB cord-335975-m6lkrehi 1102 16 to to TO cord-335975-m6lkrehi 1102 17 evaluate evaluate VB cord-335975-m6lkrehi 1102 18 HAP HAP NNP cord-335975-m6lkrehi 1102 19 VAP VAP NNP cord-335975-m6lkrehi 1102 20 treatments treatment NNS cord-335975-m6lkrehi 1102 21 differ differ VBP cord-335975-m6lkrehi 1102 22 . . . cord-335975-m6lkrehi 1103 1 The the DT cord-335975-m6lkrehi 1103 2 aim aim NN cord-335975-m6lkrehi 1103 3 of of IN cord-335975-m6lkrehi 1103 4 this this DT cord-335975-m6lkrehi 1103 5 work work NN cord-335975-m6lkrehi 1103 6 was be VBD cord-335975-m6lkrehi 1103 7 to to TO cord-335975-m6lkrehi 1103 8 reach reach VB cord-335975-m6lkrehi 1103 9 a a DT cord-335975-m6lkrehi 1103 10 consensus consensus NN cord-335975-m6lkrehi 1103 11 on on IN cord-335975-m6lkrehi 1103 12 the the DT cord-335975-m6lkrehi 1103 13 most most RBS cord-335975-m6lkrehi 1103 14 appropriate appropriate JJ cord-335975-m6lkrehi 1103 15 endpoint endpoint NN cord-335975-m6lkrehi 1103 16 to to TO cord-335975-m6lkrehi 1103 17 consider consider VB cord-335975-m6lkrehi 1103 18 in in IN cord-335975-m6lkrehi 1103 19 future future JJ cord-335975-m6lkrehi 1103 20 clinical clinical JJ cord-335975-m6lkrehi 1103 21 trials trial NNS cord-335975-m6lkrehi 1103 22 evaluating evaluate VBG cord-335975-m6lkrehi 1103 23 the the DT cord-335975-m6lkrehi 1103 24 efficacy efficacy NN cord-335975-m6lkrehi 1103 25 of of IN cord-335975-m6lkrehi 1103 26 antimicrobial antimicrobial JJ cord-335975-m6lkrehi 1103 27 treatment treatment NN cord-335975-m6lkrehi 1103 28 for for IN cord-335975-m6lkrehi 1103 29 HAP HAP NNP cord-335975-m6lkrehi 1103 30 VAP VAP NNP cord-335975-m6lkrehi 1103 31 , , , cord-335975-m6lkrehi 1103 32 using use VBG cord-335975-m6lkrehi 1103 33 Delphi Delphi NNP cord-335975-m6lkrehi 1103 34 method method NN cord-335975-m6lkrehi 1103 35 . . . cord-335975-m6lkrehi 1104 1 Patients patient NNS cord-335975-m6lkrehi 1104 2 and and CC cord-335975-m6lkrehi 1104 3 methods method NNS cord-335975-m6lkrehi 1104 4 : : : cord-335975-m6lkrehi 1104 5 Twenty twenty CD cord-335975-m6lkrehi 1104 6 - - HYPH cord-335975-m6lkrehi 1104 7 six six CD cord-335975-m6lkrehi 1104 8 international international JJ cord-335975-m6lkrehi 1104 9 experts expert NNS cord-335975-m6lkrehi 1104 10 from from IN cord-335975-m6lkrehi 1104 11 intensive intensive JJ cord-335975-m6lkrehi 1104 12 care care NN cord-335975-m6lkrehi 1104 13 , , , cord-335975-m6lkrehi 1104 14 infectious infectious JJ cord-335975-m6lkrehi 1104 15 disease disease NN cord-335975-m6lkrehi 1104 16 and and CC cord-335975-m6lkrehi 1104 17 from from IN cord-335975-m6lkrehi 1104 18 the the DT cord-335975-m6lkrehi 1104 19 industry industry NN cord-335975-m6lkrehi 1104 20 were be VBD cord-335975-m6lkrehi 1104 21 consulted consult VBN cord-335975-m6lkrehi 1104 22 using use VBG cord-335975-m6lkrehi 1104 23 Delphi Delphi NNP cord-335975-m6lkrehi 1104 24 method method NN cord-335975-m6lkrehi 1104 25 ( ( -LRB- cord-335975-m6lkrehi 1104 26 four four CD cord-335975-m6lkrehi 1104 27 successive successive JJ cord-335975-m6lkrehi 1104 28 questionnaires questionnaire NNS cord-335975-m6lkrehi 1104 29 ) ) -RRB- cord-335975-m6lkrehi 1104 30 from from IN cord-335975-m6lkrehi 1104 31 January January NNP cord-335975-m6lkrehi 1104 32 2016 2016 CD cord-335975-m6lkrehi 1104 33 to to IN cord-335975-m6lkrehi 1104 34 January January NNP cord-335975-m6lkrehi 1104 35 2017 2017 CD cord-335975-m6lkrehi 1104 36 . . . cord-335975-m6lkrehi 1105 1 More More JJR cord-335975-m6lkrehi 1105 2 than than IN cord-335975-m6lkrehi 1105 3 70 70 CD cord-335975-m6lkrehi 1105 4 % % NN cord-335975-m6lkrehi 1105 5 of of IN cord-335975-m6lkrehi 1105 6 similar similar JJ cord-335975-m6lkrehi 1105 7 answers answer NNS cord-335975-m6lkrehi 1105 8 to to IN cord-335975-m6lkrehi 1105 9 a a DT cord-335975-m6lkrehi 1105 10 question question NN cord-335975-m6lkrehi 1105 11 were be VBD cord-335975-m6lkrehi 1105 12 necessary necessary JJ cord-335975-m6lkrehi 1105 13 to to TO cord-335975-m6lkrehi 1105 14 reach reach VB cord-335975-m6lkrehi 1105 15 a a DT cord-335975-m6lkrehi 1105 16 consensus consensus NN cord-335975-m6lkrehi 1105 17 . . . cord-335975-m6lkrehi 1106 1 Results result NNS cord-335975-m6lkrehi 1106 2 : : : cord-335975-m6lkrehi 1107 1 According accord VBG cord-335975-m6lkrehi 1107 2 to to IN cord-335975-m6lkrehi 1107 3 60 60 CD cord-335975-m6lkrehi 1107 4 % % NN cord-335975-m6lkrehi 1107 5 the the DT cord-335975-m6lkrehi 1107 6 experts expert NNS cord-335975-m6lkrehi 1107 7 , , , cord-335975-m6lkrehi 1107 8 clinical clinical JJ cord-335975-m6lkrehi 1107 9 cure cure NN cord-335975-m6lkrehi 1107 10 was be VBD cord-335975-m6lkrehi 1107 11 the the DT cord-335975-m6lkrehi 1107 12 most most RBS cord-335975-m6lkrehi 1107 13 desirable desirable JJ cord-335975-m6lkrehi 1107 14 primary primary JJ cord-335975-m6lkrehi 1107 15 outcome outcome NN cord-335975-m6lkrehi 1107 16 among among IN cord-335975-m6lkrehi 1107 17 those those DT cord-335975-m6lkrehi 1107 18 found find VBN cord-335975-m6lkrehi 1107 19 in in IN cord-335975-m6lkrehi 1107 20 the the DT cord-335975-m6lkrehi 1107 21 literature literature NN cord-335975-m6lkrehi 1107 22 but but CC cord-335975-m6lkrehi 1107 23 two two CD cord-335975-m6lkrehi 1107 24 other other JJ cord-335975-m6lkrehi 1107 25 endpoints endpoint NNS cord-335975-m6lkrehi 1107 26 were be VBD cord-335975-m6lkrehi 1107 27 highly highly RB cord-335975-m6lkrehi 1107 28 rated rate VBN cord-335975-m6lkrehi 1107 29 - - HYPH cord-335975-m6lkrehi 1107 30 all all DT cord-335975-m6lkrehi 1107 31 - - HYPH cord-335975-m6lkrehi 1107 32 cause cause NN cord-335975-m6lkrehi 1107 33 mortality mortality NN cord-335975-m6lkrehi 1107 34 and and CC cord-335975-m6lkrehi 1107 35 mechanical mechanical JJ cord-335975-m6lkrehi 1107 36 ventilation ventilation NN cord-335975-m6lkrehi 1107 37 ( ( -LRB- cord-335975-m6lkrehi 1107 38 MV)-free mv)-free CD cord-335975-m6lkrehi 1107 39 days day NNS cord-335975-m6lkrehi 1107 40 . . . cord-335975-m6lkrehi 1108 1 Consequently consequently RB cord-335975-m6lkrehi 1108 2 , , , cord-335975-m6lkrehi 1108 3 88 88 CD cord-335975-m6lkrehi 1108 4 % % NN cord-335975-m6lkrehi 1108 5 of of IN cord-335975-m6lkrehi 1108 6 the the DT cord-335975-m6lkrehi 1108 7 panelists panelist NNS cord-335975-m6lkrehi 1108 8 agreed agree VBD cord-335975-m6lkrehi 1108 9 to to TO cord-335975-m6lkrehi 1108 10 use use VB cord-335975-m6lkrehi 1108 11 a a DT cord-335975-m6lkrehi 1108 12 composite composite JJ cord-335975-m6lkrehi 1108 13 endpoints endpoint NNS cord-335975-m6lkrehi 1108 14 and and CC cord-335975-m6lkrehi 1108 15 even even RB cord-335975-m6lkrehi 1108 16 a a DT cord-335975-m6lkrehi 1108 17 hierarchical hierarchical JJ cord-335975-m6lkrehi 1108 18 composite composite JJ cord-335975-m6lkrehi 1108 19 endpoint endpoint NN cord-335975-m6lkrehi 1108 20 to to TO cord-335975-m6lkrehi 1108 21 combine combine VB cord-335975-m6lkrehi 1108 22 these these DT cord-335975-m6lkrehi 1108 23 items item NNS cord-335975-m6lkrehi 1108 24 together together RB cord-335975-m6lkrehi 1108 25 in in IN cord-335975-m6lkrehi 1108 26 which which WDT cord-335975-m6lkrehi 1108 27 clinical clinical JJ cord-335975-m6lkrehi 1108 28 cure cure NN cord-335975-m6lkrehi 1108 29 and and CC cord-335975-m6lkrehi 1108 30 MV mv NN cord-335975-m6lkrehi 1108 31 - - HYPH cord-335975-m6lkrehi 1108 32 free free JJ cord-335975-m6lkrehi 1108 33 days day NNS cord-335975-m6lkrehi 1108 34 would would MD cord-335975-m6lkrehi 1108 35 be be VB cord-335975-m6lkrehi 1108 36 assessed assess VBN cord-335975-m6lkrehi 1108 37 at at IN cord-335975-m6lkrehi 1108 38 day day NN cord-335975-m6lkrehi 1108 39 28 28 CD cord-335975-m6lkrehi 1108 40 and and CC cord-335975-m6lkrehi 1108 41 clinical clinical JJ cord-335975-m6lkrehi 1108 42 cure cure NN cord-335975-m6lkrehi 1108 43 at at IN cord-335975-m6lkrehi 1108 44 day day NN cord-335975-m6lkrehi 1108 45 7 7 CD cord-335975-m6lkrehi 1108 46 after after IN cord-335975-m6lkrehi 1108 47 end end NN cord-335975-m6lkrehi 1108 48 of of IN cord-335975-m6lkrehi 1108 49 therapy therapy NN cord-335975-m6lkrehi 1108 50 . . . cord-335975-m6lkrehi 1109 1 For for IN cord-335975-m6lkrehi 1109 2 VAP VAP NNP cord-335975-m6lkrehi 1109 3 , , , cord-335975-m6lkrehi 1109 4 mortality mortality NN cord-335975-m6lkrehi 1109 5 was be VBD cord-335975-m6lkrehi 1109 6 considered consider VBN cord-335975-m6lkrehi 1109 7 as as IN cord-335975-m6lkrehi 1109 8 the the DT cord-335975-m6lkrehi 1109 9 most most RBS cord-335975-m6lkrehi 1109 10 clinically clinically RB cord-335975-m6lkrehi 1109 11 significant significant JJ cord-335975-m6lkrehi 1109 12 item item NN cord-335975-m6lkrehi 1109 13 by by IN cord-335975-m6lkrehi 1109 14 75 75 CD cord-335975-m6lkrehi 1109 15 % % NN cord-335975-m6lkrehi 1109 16 of of IN cord-335975-m6lkrehi 1109 17 the the DT cord-335975-m6lkrehi 1109 18 experts expert NNS cord-335975-m6lkrehi 1109 19 , , , cord-335975-m6lkrehi 1109 20 followed follow VBN cord-335975-m6lkrehi 1109 21 by by IN cord-335975-m6lkrehi 1109 22 MVfree MVfree NNP cord-335975-m6lkrehi 1109 23 days day NNS cord-335975-m6lkrehi 1109 24 and and CC cord-335975-m6lkrehi 1109 25 finally finally RB cord-335975-m6lkrehi 1109 26 clinical clinical JJ cord-335975-m6lkrehi 1109 27 cure cure NN cord-335975-m6lkrehi 1110 1 ( ( -LRB- cord-335975-m6lkrehi 1110 2 Fig Fig NNP cord-335975-m6lkrehi 1110 3 . . NNP cord-335975-m6lkrehi 1110 4 1 1 CD cord-335975-m6lkrehi 1110 5 ) ) -RRB- cord-335975-m6lkrehi 1110 6 . . . cord-335975-m6lkrehi 1111 1 For for IN cord-335975-m6lkrehi 1111 2 HAP HAP NNP cord-335975-m6lkrehi 1111 3 , , , cord-335975-m6lkrehi 1111 4 a a DT cord-335975-m6lkrehi 1111 5 dual dual JJ cord-335975-m6lkrehi 1111 6 composite composite JJ cord-335975-m6lkrehi 1111 7 endpoint endpoint NN cord-335975-m6lkrehi 1111 8 that that WDT cord-335975-m6lkrehi 1111 9 only only RB cord-335975-m6lkrehi 1111 10 included include VBD cord-335975-m6lkrehi 1111 11 all all DT cord-335975-m6lkrehi 1111 12 - - HYPH cord-335975-m6lkrehi 1111 13 cause cause NN cord-335975-m6lkrehi 1111 14 mortality mortality NN cord-335975-m6lkrehi 1111 15 and and CC cord-335975-m6lkrehi 1111 16 clinical clinical JJ cord-335975-m6lkrehi 1111 17 cure cure NN cord-335975-m6lkrehi 1111 18 was be VBD cord-335975-m6lkrehi 1111 19 chosen choose VBN cord-335975-m6lkrehi 1111 20 ( ( -LRB- cord-335975-m6lkrehi 1111 21 Fig Fig NNP cord-335975-m6lkrehi 1111 22 . . . cord-335975-m6lkrehi 1111 23 1 1 CD cord-335975-m6lkrehi 1111 24 ) ) -RRB- cord-335975-m6lkrehi 1111 25 . . . cord-335975-m6lkrehi 1112 1 Among among IN cord-335975-m6lkrehi 1112 2 the the DT cord-335975-m6lkrehi 1112 3 various various JJ cord-335975-m6lkrehi 1112 4 elements element NNS cord-335975-m6lkrehi 1112 5 of of IN cord-335975-m6lkrehi 1112 6 clinical clinical JJ cord-335975-m6lkrehi 1112 7 cure cure NN cord-335975-m6lkrehi 1112 8 definition definition NN cord-335975-m6lkrehi 1112 9 found find VBN cord-335975-m6lkrehi 1112 10 in in IN cord-335975-m6lkrehi 1112 11 the the DT cord-335975-m6lkrehi 1112 12 literature literature NN cord-335975-m6lkrehi 1112 13 , , , cord-335975-m6lkrehi 1112 14 only only RB cord-335975-m6lkrehi 1112 15 three three CD cord-335975-m6lkrehi 1112 16 were be VBD cord-335975-m6lkrehi 1112 17 retained retain VBN cord-335975-m6lkrehi 1112 18 by by IN cord-335975-m6lkrehi 1112 19 the the DT cord-335975-m6lkrehi 1112 20 experts expert NNS cord-335975-m6lkrehi 1112 21 - - : cord-335975-m6lkrehi 1112 22 resolution resolution NN cord-335975-m6lkrehi 1112 23 at at IN cord-335975-m6lkrehi 1112 24 end end NN cord-335975-m6lkrehi 1112 25 of of IN cord-335975-m6lkrehi 1112 26 therapy therapy NN cord-335975-m6lkrehi 1112 27 of of IN cord-335975-m6lkrehi 1112 28 signs sign NNS cord-335975-m6lkrehi 1112 29 and and CC cord-335975-m6lkrehi 1112 30 symptoms symptom NNS cord-335975-m6lkrehi 1112 31 present present JJ cord-335975-m6lkrehi 1112 32 at at IN cord-335975-m6lkrehi 1112 33 enrolment enrolment NN cord-335975-m6lkrehi 1112 34 , , , cord-335975-m6lkrehi 1112 35 no no DT cord-335975-m6lkrehi 1112 36 further further JJ cord-335975-m6lkrehi 1112 37 antimicrobial antimicrobial JJ cord-335975-m6lkrehi 1112 38 treatment treatment NN cord-335975-m6lkrehi 1112 39 needed need VBN cord-335975-m6lkrehi 1112 40 and and CC cord-335975-m6lkrehi 1112 41 resolution resolution NN cord-335975-m6lkrehi 1112 42 or or CC cord-335975-m6lkrehi 1112 43 lack lack NN cord-335975-m6lkrehi 1112 44 of of IN cord-335975-m6lkrehi 1112 45 progression progression NN cord-335975-m6lkrehi 1112 46 of of IN cord-335975-m6lkrehi 1112 47 radiological radiological JJ cord-335975-m6lkrehi 1112 48 signs sign NNS cord-335975-m6lkrehi 1112 49 of of IN cord-335975-m6lkrehi 1112 50 pneumonia pneumonia NN cord-335975-m6lkrehi 1112 51 . . . cord-335975-m6lkrehi 1113 1 Finally finally RB cord-335975-m6lkrehi 1113 2 , , , cord-335975-m6lkrehi 1113 3 we -PRON- PRP cord-335975-m6lkrehi 1113 4 found find VBD cord-335975-m6lkrehi 1113 5 a a DT cord-335975-m6lkrehi 1113 6 consensus consensus NN cord-335975-m6lkrehi 1113 7 on on IN cord-335975-m6lkrehi 1113 8 the the DT cord-335975-m6lkrehi 1113 9 signs sign NNS cord-335975-m6lkrehi 1113 10 and and CC cord-335975-m6lkrehi 1113 11 symptoms symptom NNS cord-335975-m6lkrehi 1113 12 that that WDT cord-335975-m6lkrehi 1113 13 should should MD cord-335975-m6lkrehi 1113 14 trigger trigger VB cord-335975-m6lkrehi 1113 15 the the DT cord-335975-m6lkrehi 1113 16 suspicion suspicion NN cord-335975-m6lkrehi 1113 17 of of IN cord-335975-m6lkrehi 1113 18 pneumonia pneumonia NN cord-335975-m6lkrehi 1113 19 - - HYPH cord-335975-m6lkrehi 1113 20 worsening worsen VBG cord-335975-m6lkrehi 1113 21 of of IN cord-335975-m6lkrehi 1113 22 gaz gaz NNP cord-335975-m6lkrehi 1113 23 exchange exchange NNP cord-335975-m6lkrehi 1113 24 , , , cord-335975-m6lkrehi 1113 25 purulent purulent JJ cord-335975-m6lkrehi 1113 26 tracheal tracheal JJ cord-335975-m6lkrehi 1113 27 secretions secretion NNS cord-335975-m6lkrehi 1113 28 , , , cord-335975-m6lkrehi 1113 29 hypotension hypotension NN cord-335975-m6lkrehi 1113 30 and and CC cord-335975-m6lkrehi 1113 31 or or CC cord-335975-m6lkrehi 1113 32 vasopressor vasopressor NN cord-335975-m6lkrehi 1113 33 requirements requirement NNS cord-335975-m6lkrehi 1113 34 and and CC cord-335975-m6lkrehi 1113 35 fever fever NN cord-335975-m6lkrehi 1113 36 or or CC cord-335975-m6lkrehi 1113 37 hypothermia hypothermia NN cord-335975-m6lkrehi 1113 38 . . . cord-335975-m6lkrehi 1114 1 We -PRON- PRP cord-335975-m6lkrehi 1114 2 provide provide VBP cord-335975-m6lkrehi 1114 3 here here RB cord-335975-m6lkrehi 1114 4 two two CD cord-335975-m6lkrehi 1114 5 consensual consensual JJ cord-335975-m6lkrehi 1114 6 endpoints endpoint NNS cord-335975-m6lkrehi 1114 7 ( ( -LRB- cord-335975-m6lkrehi 1114 8 for for IN cord-335975-m6lkrehi 1114 9 VAP VAP NNP cord-335975-m6lkrehi 1114 10 and and CC cord-335975-m6lkrehi 1114 11 HAP HAP NNP cord-335975-m6lkrehi 1114 12 ) ) -RRB- cord-335975-m6lkrehi 1114 13 that that WDT cord-335975-m6lkrehi 1114 14 would would MD cord-335975-m6lkrehi 1114 15 help help VB cord-335975-m6lkrehi 1114 16 addressing address VBG cord-335975-m6lkrehi 1114 17 the the DT cord-335975-m6lkrehi 1114 18 efficacy efficacy NN cord-335975-m6lkrehi 1114 19 of of IN cord-335975-m6lkrehi 1114 20 antimicrobial antimicrobial JJ cord-335975-m6lkrehi 1114 21 molecules molecule NNS cord-335975-m6lkrehi 1114 22 for for IN cord-335975-m6lkrehi 1114 23 HAP HAP NNP cord-335975-m6lkrehi 1114 24 VAP VAP NNP cord-335975-m6lkrehi 1114 25 treatment treatment NN cord-335975-m6lkrehi 1114 26 in in IN cord-335975-m6lkrehi 1114 27 future future JJ cord-335975-m6lkrehi 1114 28 clinical clinical JJ cord-335975-m6lkrehi 1114 29 trials trial NNS cord-335975-m6lkrehi 1114 30 . . . cord-335975-m6lkrehi 1115 1 ( ( -LRB- cord-335975-m6lkrehi 1115 2 Table table NN cord-335975-m6lkrehi 1115 3 ) ) -RRB- cord-335975-m6lkrehi 1115 4 . . . cord-335975-m6lkrehi 1116 1 93 93 CD cord-335975-m6lkrehi 1117 1 SM SM NNP cord-335975-m6lkrehi 1117 2 - - HYPH cord-335975-m6lkrehi 1117 3 VAP VAP NNP cord-335975-m6lkrehi 1117 4 were be VBD cord-335975-m6lkrehi 1117 5 matched match VBN cord-335975-m6lkrehi 1117 6 with with IN cord-335975-m6lkrehi 1117 7 380 380 CD cord-335975-m6lkrehi 1117 8 control control NN cord-335975-m6lkrehi 1117 9 patients patient NNS cord-335975-m6lkrehi 1117 10 . . . cord-335975-m6lkrehi 1118 1 In in IN cord-335975-m6lkrehi 1118 2 univariate univariate JJ cord-335975-m6lkrehi 1118 3 analysis analysis NN cord-335975-m6lkrehi 1118 4 , , , cord-335975-m6lkrehi 1118 5 risk risk NN cord-335975-m6lkrehi 1118 6 factors factor NNS cord-335975-m6lkrehi 1118 7 for for IN cord-335975-m6lkrehi 1118 8 SM SM NNP cord-335975-m6lkrehi 1118 9 - - HYPH cord-335975-m6lkrehi 1118 10 VAP VAP NNP cord-335975-m6lkrehi 1118 11 weremale weremale NN cord-335975-m6lkrehi 1118 12 gender gender NN cord-335975-m6lkrehi 1118 13 , , , cord-335975-m6lkrehi 1118 14 chronic chronic JJ cord-335975-m6lkrehi 1118 15 heart heart NN cord-335975-m6lkrehi 1118 16 failure failure NN cord-335975-m6lkrehi 1118 17 , , , cord-335975-m6lkrehi 1118 18 respiratory respiratory JJ cord-335975-m6lkrehi 1118 19 , , , cord-335975-m6lkrehi 1118 20 cardiovascular cardiovascular JJ cord-335975-m6lkrehi 1118 21 and and CC cord-335975-m6lkrehi 1118 22 coagulation coagulation NN cord-335975-m6lkrehi 1118 23 SOFA sofa NN cord-335975-m6lkrehi 1118 24 scores score NNS cord-335975-m6lkrehi 1118 25 two two CD cord-335975-m6lkrehi 1118 26 days day NNS cord-335975-m6lkrehi 1118 27 before before IN cord-335975-m6lkrehi 1118 28 VAP VAP NNP cord-335975-m6lkrehi 1118 29 , , , cord-335975-m6lkrehi 1118 30 median median JJ cord-335975-m6lkrehi 1118 31 number number NN cord-335975-m6lkrehi 1118 32 of of IN cord-335975-m6lkrehi 1118 33 antibiotics antibiotic NNS cord-335975-m6lkrehi 1118 34 used use VBN cord-335975-m6lkrehi 1118 35 , , , cord-335975-m6lkrehi 1118 36 percentage percentage NN cord-335975-m6lkrehi 1118 37 of of IN cord-335975-m6lkrehi 1118 38 time time NN cord-335975-m6lkrehi 1118 39 with with IN cord-335975-m6lkrehi 1118 40 antibiotics antibiotic NNS cord-335975-m6lkrehi 1118 41 before before IN cord-335975-m6lkrehi 1118 42 VAP VAP NNP cord-335975-m6lkrehi 1118 43 , , , cord-335975-m6lkrehi 1118 44 parenteral parenteral JJ cord-335975-m6lkrehi 1118 45 nutrition nutrition NN cord-335975-m6lkrehi 1118 46 , , , cord-335975-m6lkrehi 1118 47 dialysis dialysis NN cord-335975-m6lkrehi 1118 48 , , , cord-335975-m6lkrehi 1118 49 catecholamine catecholamine NN cord-335975-m6lkrehi 1118 50 use use NN cord-335975-m6lkrehi 1118 51 and and CC cord-335975-m6lkrehi 1118 52 exposure exposure NN cord-335975-m6lkrehi 1118 53 to to IN cord-335975-m6lkrehi 1118 54 Ureido Ureido NNP cord-335975-m6lkrehi 1118 55 - - HYPH cord-335975-m6lkrehi 1118 56 carboxypenicillin carboxypenicillin NNP cord-335975-m6lkrehi 1118 57 , , , cord-335975-m6lkrehi 1118 58 Ciprofloxacin Ciprofloxacin NNP cord-335975-m6lkrehi 1118 59 , , , cord-335975-m6lkrehi 1118 60 Tazobactam Tazobactam NNP cord-335975-m6lkrehi 1118 61 or or CC cord-335975-m6lkrehi 1118 62 Imipenem Imipenem NNP cord-335975-m6lkrehi 1118 63 - - HYPH cord-335975-m6lkrehi 1118 64 Meropenem Meropenem NNP cord-335975-m6lkrehi 1118 65 during during IN cord-335975-m6lkrehi 1118 66 the the DT cord-335975-m6lkrehi 1118 67 week week NN cord-335975-m6lkrehi 1118 68 before before IN cord-335975-m6lkrehi 1118 69 VAP VAP NNP cord-335975-m6lkrehi 1118 70 ( ( -LRB- cord-335975-m6lkrehi 1118 71 Table Table NNP cord-335975-m6lkrehi 1118 72 ) ) -RRB- cord-335975-m6lkrehi 1118 73 . . . cord-335975-m6lkrehi 1119 1 Patients patient NNS cord-335975-m6lkrehi 1119 2 with with IN cord-335975-m6lkrehi 1119 3 SM SM NNP cord-335975-m6lkrehi 1119 4 - - HYPH cord-335975-m6lkrehi 1119 5 VAP VAP NNP cord-335975-m6lkrehi 1119 6 were be VBD cord-335975-m6lkrehi 1119 7 less less RBR cord-335975-m6lkrehi 1119 8 likely likely JJ cord-335975-m6lkrehi 1119 9 to to TO cord-335975-m6lkrehi 1119 10 receive receive VB cord-335975-m6lkrehi 1119 11 initial initial JJ cord-335975-m6lkrehi 1119 12 adequate adequate JJ cord-335975-m6lkrehi 1119 13 therapy therapy NN cord-335975-m6lkrehi 1119 14 ( ( -LRB- cord-335975-m6lkrehi 1119 15 56 56 CD cord-335975-m6lkrehi 1119 16 vs vs IN cord-335975-m6lkrehi 1119 17 70 70 CD cord-335975-m6lkrehi 1119 18 % % NN cord-335975-m6lkrehi 1119 19 , , , cord-335975-m6lkrehi 1119 20 OR or CC cord-335975-m6lkrehi 1119 21 0.53 0.53 CD cord-335975-m6lkrehi 1119 22 , , , cord-335975-m6lkrehi 1119 23 p p NN cord-335975-m6lkrehi 1119 24 = = SYM cord-335975-m6lkrehi 1119 25 0.01 0.01 CD cord-335975-m6lkrehi 1119 26 ) ) -RRB- cord-335975-m6lkrehi 1119 27 . . . cord-335975-m6lkrehi 1120 1 There there EX cord-335975-m6lkrehi 1120 2 was be VBD cord-335975-m6lkrehi 1120 3 no no DT cord-335975-m6lkrehi 1120 4 statistical statistical JJ cord-335975-m6lkrehi 1120 5 difference difference NN cord-335975-m6lkrehi 1120 6 for for IN cord-335975-m6lkrehi 1120 7 ICU ICU NNP cord-335975-m6lkrehi 1120 8 or or CC cord-335975-m6lkrehi 1120 9 D30 D30 NNP cord-335975-m6lkrehi 1120 10 mortality mortality NN cord-335975-m6lkrehi 1120 11 . . . cord-335975-m6lkrehi 1121 1 D60 D60 NNP cord-335975-m6lkrehi 1121 2 mortality mortality NN cord-335975-m6lkrehi 1121 3 was be VBD cord-335975-m6lkrehi 1121 4 higher high JJR cord-335975-m6lkrehi 1121 5 for for IN cord-335975-m6lkrehi 1121 6 SM SM NNP cord-335975-m6lkrehi 1121 7 - - HYPH cord-335975-m6lkrehi 1121 8 VAP VAP NNP cord-335975-m6lkrehi 1121 9 ( ( -LRB- cord-335975-m6lkrehi 1121 10 Table table NN cord-335975-m6lkrehi 1121 11 ) ) -RRB- cord-335975-m6lkrehi 1121 12 . . . cord-335975-m6lkrehi 1122 1 In in IN cord-335975-m6lkrehi 1122 2 multivariate multivariate JJ cord-335975-m6lkrehi 1122 3 analysis analysis NN cord-335975-m6lkrehi 1122 4 , , , cord-335975-m6lkrehi 1122 5 exposure exposure NN cord-335975-m6lkrehi 1122 6 to to IN cord-335975-m6lkrehi 1122 7 Imipenem Imipenem NNP cord-335975-m6lkrehi 1122 8 - - HYPH cord-335975-m6lkrehi 1122 9 Meropenem Meropenem NNP cord-335975-m6lkrehi 1122 10 during during IN cord-335975-m6lkrehi 1122 11 the the DT cord-335975-m6lkrehi 1122 12 week week NN cord-335975-m6lkrehi 1122 13 before before IN cord-335975-m6lkrehi 1122 14 VAP VAP NNP cord-335975-m6lkrehi 1122 15 , , , cord-335975-m6lkrehi 1122 16 respiratory respiratory JJ cord-335975-m6lkrehi 1122 17 and and CC cord-335975-m6lkrehi 1122 18 coagulation coagulation NN cord-335975-m6lkrehi 1122 19 SOFA sofa NN cord-335975-m6lkrehi 1122 20 scores score NNS cord-335975-m6lkrehi 1122 21 two two CD cord-335975-m6lkrehi 1122 22 days day NNS cord-335975-m6lkrehi 1122 23 before before IN cord-335975-m6lkrehi 1122 24 VAP VAP NNP cord-335975-m6lkrehi 1122 25 were be VBD cord-335975-m6lkrehi 1122 26 independent independent JJ cord-335975-m6lkrehi 1122 27 risk risk NN cord-335975-m6lkrehi 1122 28 factors factor NNS cord-335975-m6lkrehi 1122 29 for for IN cord-335975-m6lkrehi 1122 30 SM SM NNP cord-335975-m6lkrehi 1122 31 - - HYPH cord-335975-m6lkrehi 1122 32 VAP VAP NNP cord-335975-m6lkrehi 1122 33 . . . cord-335975-m6lkrehi 1123 1 SAPSII SAPSII NNP cord-335975-m6lkrehi 1123 2 : : : cord-335975-m6lkrehi 1124 1 Simplified Simplified NNP cord-335975-m6lkrehi 1124 2 Acute Acute NNP cord-335975-m6lkrehi 1124 3 Physiology Physiology NNP cord-335975-m6lkrehi 1124 4 Score score NN cord-335975-m6lkrehi 1124 5 ; ; : cord-335975-m6lkrehi 1124 6 SOFA sofa NN cord-335975-m6lkrehi 1124 7 : : : cord-335975-m6lkrehi 1124 8 SOFA sofa NN cord-335975-m6lkrehi 1124 9 ( ( -LRB- cord-335975-m6lkrehi 1124 10 Sequential Sequential NNP cord-335975-m6lkrehi 1124 11 Organ Organ NNP cord-335975-m6lkrehi 1124 12 Failure Failure NNP cord-335975-m6lkrehi 1124 13 Assessment Assessment NNP cord-335975-m6lkrehi 1124 14 ) ) -RRB- cord-335975-m6lkrehi 1124 15 ; ; : cord-335975-m6lkrehi 1124 16 SOFA SOFA NNP cord-335975-m6lkrehi 1124 17 Resp Resp NNP cord-335975-m6lkrehi 1124 18 : : : cord-335975-m6lkrehi 1124 19 SOFA sofa NN cord-335975-m6lkrehi 1124 20 respiratory respiratory JJ cord-335975-m6lkrehi 1124 21 score score NN cord-335975-m6lkrehi 1124 22 ; ; : cord-335975-m6lkrehi 1124 23 SOFA sofa NN cord-335975-m6lkrehi 1124 24 coag coag NN cord-335975-m6lkrehi 1124 25 : : : cord-335975-m6lkrehi 1124 26 SOFA sofa NN cord-335975-m6lkrehi 1124 27 coagulation coagulation NN cord-335975-m6lkrehi 1124 28 score score NN cord-335975-m6lkrehi 1124 29 ; ; . cord-335975-m6lkrehi 1125 1 SOFA SOFA NNP cord-335975-m6lkrehi 1125 2 cardio cardio NN cord-335975-m6lkrehi 1125 3 : : : cord-335975-m6lkrehi 1125 4 SOFA sofa NN cord-335975-m6lkrehi 1125 5 cardiovascular cardiovascular JJ cord-335975-m6lkrehi 1125 6 score score NN cord-335975-m6lkrehi 1125 7 Conclusion conclusion NN cord-335975-m6lkrehi 1125 8 : : : cord-335975-m6lkrehi 1126 1 SM SM NNP cord-335975-m6lkrehi 1126 2 - - HYPH cord-335975-m6lkrehi 1126 3 VAP VAP NNP cord-335975-m6lkrehi 1126 4 represented represent VBD cord-335975-m6lkrehi 1126 5 6.2 6.2 CD cord-335975-m6lkrehi 1126 6 % % NN cord-335975-m6lkrehi 1126 7 of of IN cord-335975-m6lkrehi 1126 8 VAP VAP NNP cord-335975-m6lkrehi 1126 9 . . . cord-335975-m6lkrehi 1127 1 We -PRON- PRP cord-335975-m6lkrehi 1127 2 observed observe VBD cord-335975-m6lkrehi 1127 3 no no DT cord-335975-m6lkrehi 1127 4 differences difference NNS cord-335975-m6lkrehi 1127 5 in in IN cord-335975-m6lkrehi 1127 6 patients patient NNS cord-335975-m6lkrehi 1127 7 characteristics characteristic NNS cord-335975-m6lkrehi 1127 8 between between IN cord-335975-m6lkrehi 1127 9 the the DT cord-335975-m6lkrehi 1127 10 groups group NNS cord-335975-m6lkrehi 1127 11 . . . cord-335975-m6lkrehi 1128 1 Imipenem Imipenem NNP cord-335975-m6lkrehi 1128 2 - - HYPH cord-335975-m6lkrehi 1128 3 Meropenem Meropenem NNP cord-335975-m6lkrehi 1128 4 use use VBP cord-335975-m6lkrehi 1128 5 during during IN cord-335975-m6lkrehi 1128 6 the the DT cord-335975-m6lkrehi 1128 7 week week NN cord-335975-m6lkrehi 1128 8 before before IN cord-335975-m6lkrehi 1128 9 VAP VAP NNP cord-335975-m6lkrehi 1128 10 was be VBD cord-335975-m6lkrehi 1128 11 the the DT cord-335975-m6lkrehi 1128 12 most most RBS cord-335975-m6lkrehi 1128 13 important important JJ cord-335975-m6lkrehi 1128 14 risk risk NN cord-335975-m6lkrehi 1128 15 factor factor NN cord-335975-m6lkrehi 1128 16 for for IN cord-335975-m6lkrehi 1128 17 SM SM NNP cord-335975-m6lkrehi 1128 18 - - HYPH cord-335975-m6lkrehi 1128 19 VAP VAP NNP cord-335975-m6lkrehi 1128 20 . . . cord-335975-m6lkrehi 1129 1 The the DT cord-335975-m6lkrehi 1129 2 higher high JJR cord-335975-m6lkrehi 1129 3 risk risk NN cord-335975-m6lkrehi 1129 4 of of IN cord-335975-m6lkrehi 1129 5 inadequate inadequate JJ cord-335975-m6lkrehi 1129 6 initial initial JJ cord-335975-m6lkrehi 1129 7 therapy therapy NN cord-335975-m6lkrehi 1129 8 with with IN cord-335975-m6lkrehi 1129 9 SM SM NNP cord-335975-m6lkrehi 1129 10 - - HYPH cord-335975-m6lkrehi 1129 11 VAP VAP NNP cord-335975-m6lkrehi 1129 12 had have VBD cord-335975-m6lkrehi 1129 13 no no DT cord-335975-m6lkrehi 1129 14 impact impact NN cord-335975-m6lkrehi 1129 15 on on IN cord-335975-m6lkrehi 1129 16 D30 D30 NNP cord-335975-m6lkrehi 1129 17 mortality mortality NN cord-335975-m6lkrehi 1129 18 but but CC cord-335975-m6lkrehi 1129 19 D60 D60 NNP cord-335975-m6lkrehi 1129 20 mortality mortality NN cord-335975-m6lkrehi 1129 21 was be VBD cord-335975-m6lkrehi 1129 22 significantly significantly RB cord-335975-m6lkrehi 1129 23 higher high JJR cord-335975-m6lkrehi 1129 24 . . . cord-335975-m6lkrehi 1130 1 Introduction introduction NN cord-335975-m6lkrehi 1130 2 : : : cord-335975-m6lkrehi 1131 1 Education education NN cord-335975-m6lkrehi 1131 2 of of IN cord-335975-m6lkrehi 1131 3 undergraduate undergraduate JJ cord-335975-m6lkrehi 1131 4 students student NNS cord-335975-m6lkrehi 1131 5 is be VBZ cord-335975-m6lkrehi 1131 6 key key JJ cord-335975-m6lkrehi 1131 7 to to TO cord-335975-m6lkrehi 1131 8 improve improve VB cord-335975-m6lkrehi 1131 9 Hand hand NN cord-335975-m6lkrehi 1131 10 hygiene hygiene NN cord-335975-m6lkrehi 1131 11 ( ( -LRB- cord-335975-m6lkrehi 1131 12 HH HH NNP cord-335975-m6lkrehi 1131 13 ) ) -RRB- cord-335975-m6lkrehi 1131 14 behavioral behavioral JJ cord-335975-m6lkrehi 1131 15 changes change NNS cord-335975-m6lkrehi 1131 16 amongst amongst IN cord-335975-m6lkrehi 1131 17 doctors doctor NNS cord-335975-m6lkrehi 1131 18 [ [ -LRB- cord-335975-m6lkrehi 1131 19 1.2 1.2 CD cord-335975-m6lkrehi 1131 20 ] ] -RRB- cord-335975-m6lkrehi 1131 21 . . . cord-335975-m6lkrehi 1132 1 Our -PRON- PRP$ cord-335975-m6lkrehi 1132 2 aim aim NN cord-335975-m6lkrehi 1132 3 was be VBD cord-335975-m6lkrehi 1132 4 to to TO cord-335975-m6lkrehi 1132 5 evaluate evaluate VB cord-335975-m6lkrehi 1132 6 personal personal JJ cord-335975-m6lkrehi 1132 7 feedback feedback NN cord-335975-m6lkrehi 1132 8 using use VBG cord-335975-m6lkrehi 1132 9 Ultraviolet Ultraviolet NNP cord-335975-m6lkrehi 1132 10 ( ( -LRB- cord-335975-m6lkrehi 1132 11 UV uv NN cord-335975-m6lkrehi 1132 12 ) ) -RRB- cord-335975-m6lkrehi 1132 13 light light JJ cord-335975-m6lkrehi 1132 14 inspection inspection NN cord-335975-m6lkrehi 1132 15 cabinets cabinet NNS cord-335975-m6lkrehi 1132 16 in in IN cord-335975-m6lkrehi 1132 17 a a DT cord-335975-m6lkrehi 1132 18 2 2 CD cord-335975-m6lkrehi 1132 19 years year NNS cord-335975-m6lkrehi 1132 20 program program NN cord-335975-m6lkrehi 1132 21 . . . cord-335975-m6lkrehi 1133 1 Our -PRON- PRP$ cord-335975-m6lkrehi 1133 2 hypothesis hypothesis NN cord-335975-m6lkrehi 1133 3 was be VBD cord-335975-m6lkrehi 1133 4 that that IN cord-335975-m6lkrehi 1133 5 its -PRON- PRP$ cord-335975-m6lkrehi 1133 6 use use NN cord-335975-m6lkrehi 1133 7 for for IN cord-335975-m6lkrehi 1133 8 Alcohol Alcohol NNP cord-335975-m6lkrehi 1133 9 hand hand NN cord-335975-m6lkrehi 1133 10 rub rub NN cord-335975-m6lkrehi 1133 11 ( ( -LRB- cord-335975-m6lkrehi 1133 12 AHR AHR NNP cord-335975-m6lkrehi 1133 13 ) ) -RRB- cord-335975-m6lkrehi 1133 14 application application NN cord-335975-m6lkrehi 1133 15 on on IN cord-335975-m6lkrehi 1133 16 first first JJ cord-335975-m6lkrehi 1133 17 year year NN cord-335975-m6lkrehi 1133 18 would would MD cord-335975-m6lkrehi 1133 19 increase increase VB cord-335975-m6lkrehi 1133 20 complete complete JJ cord-335975-m6lkrehi 1133 21 AHR AHR NNP cord-335975-m6lkrehi 1133 22 application application NN cord-335975-m6lkrehi 1133 23 on on IN cord-335975-m6lkrehi 1133 24 2nd 2nd JJ cord-335975-m6lkrehi 1133 25 year year NN cord-335975-m6lkrehi 1133 26 . . . cord-335975-m6lkrehi 1134 1 Patients patient NNS cord-335975-m6lkrehi 1134 2 and and CC cord-335975-m6lkrehi 1134 3 methods method NNS cord-335975-m6lkrehi 1135 1 : : : cord-335975-m6lkrehi 1135 2 This this DT cord-335975-m6lkrehi 1135 3 was be VBD cord-335975-m6lkrehi 1135 4 a a DT cord-335975-m6lkrehi 1135 5 simple simple JJ cord-335975-m6lkrehi 1135 6 blind blind JJ cord-335975-m6lkrehi 1135 7 randomized randomized JJ cord-335975-m6lkrehi 1135 8 trial trial NN cord-335975-m6lkrehi 1135 9 comparing compare VBG cord-335975-m6lkrehi 1135 10 HH HH NNP cord-335975-m6lkrehi 1135 11 training training NN cord-335975-m6lkrehi 1135 12 with with IN cord-335975-m6lkrehi 1135 13 personal personal JJ cord-335975-m6lkrehi 1135 14 feedback feedback NN cord-335975-m6lkrehi 1135 15 using use VBG cord-335975-m6lkrehi 1135 16 UV uv NN cord-335975-m6lkrehi 1135 17 cabinet cabinet NN cord-335975-m6lkrehi 1135 18 to to IN cord-335975-m6lkrehi 1135 19 a a DT cord-335975-m6lkrehi 1135 20 control control NN cord-335975-m6lkrehi 1135 21 group group NN cord-335975-m6lkrehi 1135 22 . . . cord-335975-m6lkrehi 1136 1 On on IN cord-335975-m6lkrehi 1136 2 first first JJ cord-335975-m6lkrehi 1136 3 year year NN cord-335975-m6lkrehi 1136 4 , , , cord-335975-m6lkrehi 1136 5 students student NNS cord-335975-m6lkrehi 1136 6 had have VBD cord-335975-m6lkrehi 1136 7 access access NN cord-335975-m6lkrehi 1136 8 to to IN cord-335975-m6lkrehi 1136 9 a a DT cord-335975-m6lkrehi 1136 10 theoretical theoretical JJ cord-335975-m6lkrehi 1136 11 formation formation NN cord-335975-m6lkrehi 1136 12 then then RB cord-335975-m6lkrehi 1136 13 were be VBD cord-335975-m6lkrehi 1136 14 convened convene VBN cord-335975-m6lkrehi 1136 15 by by IN cord-335975-m6lkrehi 1136 16 groups group NNS cord-335975-m6lkrehi 1136 17 for for IN cord-335975-m6lkrehi 1136 18 a a DT cord-335975-m6lkrehi 1136 19 demonstration demonstration NN cord-335975-m6lkrehi 1136 20 of of IN cord-335975-m6lkrehi 1136 21 the the DT cord-335975-m6lkrehi 1136 22 correct correct JJ cord-335975-m6lkrehi 1136 23 execution execution NN cord-335975-m6lkrehi 1136 24 of of IN cord-335975-m6lkrehi 1136 25 world world NNP cord-335975-m6lkrehi 1136 26 health health NNP cord-335975-m6lkrehi 1136 27 organization organization NNP cord-335975-m6lkrehi 1136 28 's 's POS cord-335975-m6lkrehi 1136 29 ( ( -LRB- cord-335975-m6lkrehi 1136 30 WHO who WP cord-335975-m6lkrehi 1136 31 ) ) -RRB- cord-335975-m6lkrehi 1136 32 procedure procedure NN cord-335975-m6lkrehi 1136 33 [ [ -LRB- cord-335975-m6lkrehi 1136 34 3 3 CD cord-335975-m6lkrehi 1136 35 ] ] -RRB- cord-335975-m6lkrehi 1136 36 . . . cord-335975-m6lkrehi 1137 1 Before before IN cord-335975-m6lkrehi 1137 2 HH HH NNP cord-335975-m6lkrehi 1137 3 training training NN cord-335975-m6lkrehi 1137 4 , , , cord-335975-m6lkrehi 1137 5 each each DT cord-335975-m6lkrehi 1137 6 group group NN cord-335975-m6lkrehi 1137 7 underwent undergo VBD cord-335975-m6lkrehi 1137 8 a a DT cord-335975-m6lkrehi 1137 9 cluster cluster NN cord-335975-m6lkrehi 1137 10 randomization randomization NN cord-335975-m6lkrehi 1137 11 . . . cord-335975-m6lkrehi 1138 1 In in IN cord-335975-m6lkrehi 1138 2 the the DT cord-335975-m6lkrehi 1138 3 control control NN cord-335975-m6lkrehi 1138 4 group group NN cord-335975-m6lkrehi 1138 5 , , , cord-335975-m6lkrehi 1138 6 the the DT cord-335975-m6lkrehi 1138 7 student student NN cord-335975-m6lkrehi 1138 8 hand hand NN cord-335975-m6lkrehi 1138 9 rubbed rub VBD cord-335975-m6lkrehi 1138 10 under under IN cord-335975-m6lkrehi 1138 11 visual visual JJ cord-335975-m6lkrehi 1138 12 supervision supervision NN cord-335975-m6lkrehi 1138 13 and and CC cord-335975-m6lkrehi 1138 14 advises advise NNS cord-335975-m6lkrehi 1138 15 of of IN cord-335975-m6lkrehi 1138 16 a a DT cord-335975-m6lkrehi 1138 17 trainer trainer NN cord-335975-m6lkrehi 1138 18 . . . cord-335975-m6lkrehi 1139 1 In in IN cord-335975-m6lkrehi 1139 2 the the DT cord-335975-m6lkrehi 1139 3 intervention intervention NN cord-335975-m6lkrehi 1139 4 group group NN cord-335975-m6lkrehi 1139 5 after after IN cord-335975-m6lkrehi 1139 6 the the DT cord-335975-m6lkrehi 1139 7 same same JJ cord-335975-m6lkrehi 1139 8 visual visual JJ cord-335975-m6lkrehi 1139 9 assessment assessment NN cord-335975-m6lkrehi 1139 10 , , , cord-335975-m6lkrehi 1139 11 completeness completeness NN cord-335975-m6lkrehi 1139 12 of of IN cord-335975-m6lkrehi 1139 13 AHR AHR NNP cord-335975-m6lkrehi 1139 14 hand hand NN cord-335975-m6lkrehi 1139 15 application application NN cord-335975-m6lkrehi 1139 16 was be VBD cord-335975-m6lkrehi 1139 17 recorded record VBN cord-335975-m6lkrehi 1139 18 under under IN cord-335975-m6lkrehi 1139 19 UV uv NN cord-335975-m6lkrehi 1139 20 light light NN cord-335975-m6lkrehi 1139 21 and and CC cord-335975-m6lkrehi 1139 22 shown show VBN cord-335975-m6lkrehi 1139 23 to to IN cord-335975-m6lkrehi 1139 24 the the DT cord-335975-m6lkrehi 1139 25 student student NN cord-335975-m6lkrehi 1139 26 . . . cord-335975-m6lkrehi 1140 1 He -PRON- PRP cord-335975-m6lkrehi 1140 2 was be VBD cord-335975-m6lkrehi 1140 3 given give VBN cord-335975-m6lkrehi 1140 4 free free JJ cord-335975-m6lkrehi 1140 5 access access NN cord-335975-m6lkrehi 1140 6 to to IN cord-335975-m6lkrehi 1140 7 the the DT cord-335975-m6lkrehi 1140 8 UV uv NN cord-335975-m6lkrehi 1140 9 cabinet cabinet NN cord-335975-m6lkrehi 1140 10 to to TO cord-335975-m6lkrehi 1140 11 repeat repeat VB cord-335975-m6lkrehi 1140 12 the the DT cord-335975-m6lkrehi 1140 13 technique technique NN cord-335975-m6lkrehi 1140 14 , , , cord-335975-m6lkrehi 1140 15 until until IN cord-335975-m6lkrehi 1140 16 perfect perfect JJ cord-335975-m6lkrehi 1140 17 application application NN cord-335975-m6lkrehi 1140 18 complete complete JJ cord-335975-m6lkrehi 1140 19 under under IN cord-335975-m6lkrehi 1140 20 UV uv NN cord-335975-m6lkrehi 1140 21 light light NN cord-335975-m6lkrehi 1140 22 . . . cord-335975-m6lkrehi 1141 1 An an DT cord-335975-m6lkrehi 1141 2 enhancement enhancement NN cord-335975-m6lkrehi 1141 3 with with IN cord-335975-m6lkrehi 1141 4 a a DT cord-335975-m6lkrehi 1141 5 scenario scenario NN cord-335975-m6lkrehi 1141 6 - - HYPH cord-335975-m6lkrehi 1141 7 based base VBN cord-335975-m6lkrehi 1141 8 learning learning NN cord-335975-m6lkrehi 1141 9 was be VBD cord-335975-m6lkrehi 1141 10 proposed propose VBN cord-335975-m6lkrehi 1141 11 to to IN cord-335975-m6lkrehi 1141 12 both both DT cord-335975-m6lkrehi 1141 13 groups group NNS cord-335975-m6lkrehi 1141 14 . . . cord-335975-m6lkrehi 1142 1 On on IN cord-335975-m6lkrehi 1142 2 second second JJ cord-335975-m6lkrehi 1142 3 year year NN cord-335975-m6lkrehi 1142 4 , , , cord-335975-m6lkrehi 1142 5 every every DT cord-335975-m6lkrehi 1142 6 student student NN cord-335975-m6lkrehi 1142 7 were be VBD cord-335975-m6lkrehi 1142 8 asked ask VBN cord-335975-m6lkrehi 1142 9 to to TO cord-335975-m6lkrehi 1142 10 hand hand VB cord-335975-m6lkrehi 1142 11 rub rub NN cord-335975-m6lkrehi 1142 12 with with IN cord-335975-m6lkrehi 1142 13 the the DT cord-335975-m6lkrehi 1142 14 fluorescent fluorescent NN cord-335975-m6lkrehi 1142 15 AHR AHR NNP cord-335975-m6lkrehi 1142 16 . . . cord-335975-m6lkrehi 1143 1 A a DT cord-335975-m6lkrehi 1143 2 supervisor supervisor NN cord-335975-m6lkrehi 1143 3 blinded blind VBN cord-335975-m6lkrehi 1143 4 to to IN cord-335975-m6lkrehi 1143 5 the the DT cord-335975-m6lkrehi 1143 6 group group NN cord-335975-m6lkrehi 1143 7 of of IN cord-335975-m6lkrehi 1143 8 randomization randomization NN cord-335975-m6lkrehi 1143 9 assessed assess VBD cord-335975-m6lkrehi 1143 10 the the DT cord-335975-m6lkrehi 1143 11 quality quality NN cord-335975-m6lkrehi 1143 12 of of IN cord-335975-m6lkrehi 1143 13 the the DT cord-335975-m6lkrehi 1143 14 HH HH NNP cord-335975-m6lkrehi 1143 15 procedure procedure NN cord-335975-m6lkrehi 1143 16 visually visually RB cord-335975-m6lkrehi 1143 17 , , , cord-335975-m6lkrehi 1143 18 the the DT cord-335975-m6lkrehi 1143 19 completeness completeness NN cord-335975-m6lkrehi 1143 20 of of IN cord-335975-m6lkrehi 1143 21 hand hand NN cord-335975-m6lkrehi 1143 22 application application NN cord-335975-m6lkrehi 1143 23 under under IN cord-335975-m6lkrehi 1143 24 UV uv NN cord-335975-m6lkrehi 1143 25 light light NN cord-335975-m6lkrehi 1143 26 and and CC cord-335975-m6lkrehi 1143 27 compliance compliance NN cord-335975-m6lkrehi 1143 28 with with IN cord-335975-m6lkrehi 1143 29 the the DT cord-335975-m6lkrehi 1143 30 WHO who WP cord-335975-m6lkrehi 1143 31 's 's POS cord-335975-m6lkrehi 1143 32 opportunities opportunity NNS cord-335975-m6lkrehi 1143 33 for for IN cord-335975-m6lkrehi 1143 34 HH HH NNP cord-335975-m6lkrehi 1143 35 during during IN cord-335975-m6lkrehi 1143 36 the the DT cord-335975-m6lkrehi 1143 37 simulation simulation NN cord-335975-m6lkrehi 1143 38 . . . cord-335975-m6lkrehi 1144 1 Results result NNS cord-335975-m6lkrehi 1144 2 : : : cord-335975-m6lkrehi 1145 1 After after IN cord-335975-m6lkrehi 1145 2 randomization randomization NN cord-335975-m6lkrehi 1145 3 140 140 CD cord-335975-m6lkrehi 1145 4 students student NNS cord-335975-m6lkrehi 1145 5 were be VBD cord-335975-m6lkrehi 1145 6 included include VBN cord-335975-m6lkrehi 1145 7 in in IN cord-335975-m6lkrehi 1145 8 the the DT cord-335975-m6lkrehi 1145 9 intervention intervention NN cord-335975-m6lkrehi 1145 10 group group NN cord-335975-m6lkrehi 1145 11 and and CC cord-335975-m6lkrehi 1145 12 102 102 CD cord-335975-m6lkrehi 1145 13 in in IN cord-335975-m6lkrehi 1145 14 the the DT cord-335975-m6lkrehi 1145 15 control control NN cord-335975-m6lkrehi 1145 16 group group NN cord-335975-m6lkrehi 1145 17 . . . cord-335975-m6lkrehi 1146 1 On on IN cord-335975-m6lkrehi 1146 2 second second JJ cord-335975-m6lkrehi 1146 3 year year NN cord-335975-m6lkrehi 1146 4 , , , cord-335975-m6lkrehi 1146 5 the the DT cord-335975-m6lkrehi 1146 6 rate rate NN cord-335975-m6lkrehi 1146 7 of of IN cord-335975-m6lkrehi 1146 8 complete complete JJ cord-335975-m6lkrehi 1146 9 application application NN cord-335975-m6lkrehi 1146 10 of of IN cord-335975-m6lkrehi 1146 11 the the DT cord-335975-m6lkrehi 1146 12 AHR AHR NNP cord-335975-m6lkrehi 1146 13 under under IN cord-335975-m6lkrehi 1146 14 UV uv NN cord-335975-m6lkrehi 1146 15 was be VBD cord-335975-m6lkrehi 1146 16 increased increase VBN cord-335975-m6lkrehi 1146 17 in in IN cord-335975-m6lkrehi 1146 18 the the DT cord-335975-m6lkrehi 1146 19 intervention intervention NN cord-335975-m6lkrehi 1146 20 group group NN cord-335975-m6lkrehi 1146 21 as as IN cord-335975-m6lkrehi 1146 22 compared compare VBN cord-335975-m6lkrehi 1146 23 with with IN cord-335975-m6lkrehi 1146 24 the the DT cord-335975-m6lkrehi 1146 25 control control NN cord-335975-m6lkrehi 1146 26 group group NN cord-335975-m6lkrehi 1146 27 ( ( -LRB- cord-335975-m6lkrehi 1146 28 60 60 CD cord-335975-m6lkrehi 1146 29 % % NN cord-335975-m6lkrehi 1146 30 versus versus IN cord-335975-m6lkrehi 1146 31 30.4 30.4 CD cord-335975-m6lkrehi 1146 32 % % NN cord-335975-m6lkrehi 1146 33 p p NN cord-335975-m6lkrehi 1146 34 < < XX cord-335975-m6lkrehi 1146 35 0.001 0.001 CD cord-335975-m6lkrehi 1146 36 ) ) -RRB- cord-335975-m6lkrehi 1147 1 ( ( -LRB- cord-335975-m6lkrehi 1147 2 Fig Fig NNP cord-335975-m6lkrehi 1147 3 . . . cord-335975-m6lkrehi 1148 1 1 1 LS cord-335975-m6lkrehi 1148 2 ) ) -RRB- cord-335975-m6lkrehi 1149 1 despite despite IN cord-335975-m6lkrehi 1149 2 that that DT cord-335975-m6lkrehi 1149 3 visual visual JJ cord-335975-m6lkrehi 1149 4 assessment assessment NN cord-335975-m6lkrehi 1149 5 of of IN cord-335975-m6lkrehi 1149 6 HH HH NNP cord-335975-m6lkrehi 1149 7 procedures procedure NNS cord-335975-m6lkrehi 1149 8 was be VBD cord-335975-m6lkrehi 1149 9 similar similar JJ cord-335975-m6lkrehi 1149 10 between between IN cord-335975-m6lkrehi 1149 11 the the DT cord-335975-m6lkrehi 1149 12 two two CD cord-335975-m6lkrehi 1149 13 groups group NNS cord-335975-m6lkrehi 1149 14 . . . cord-335975-m6lkrehi 1150 1 In in IN cord-335975-m6lkrehi 1150 2 a a DT cord-335975-m6lkrehi 1150 3 logistic logistic JJ cord-335975-m6lkrehi 1150 4 regression regression NN cord-335975-m6lkrehi 1150 5 model model NN cord-335975-m6lkrehi 1150 6 including include VBG cord-335975-m6lkrehi 1150 7 gender gender NN cord-335975-m6lkrehi 1150 8 , , , cord-335975-m6lkrehi 1150 9 intercurrent intercurrent NN cord-335975-m6lkrehi 1150 10 HH hh NN cord-335975-m6lkrehi 1150 11 formation formation NN cord-335975-m6lkrehi 1150 12 , , , cord-335975-m6lkrehi 1150 13 intercurrent intercurrent NN cord-335975-m6lkrehi 1150 14 UV uv NN cord-335975-m6lkrehi 1150 15 cabinet cabinet NN cord-335975-m6lkrehi 1150 16 use use NN cord-335975-m6lkrehi 1150 17 , , , cord-335975-m6lkrehi 1150 18 surgical surgical JJ cord-335975-m6lkrehi 1150 19 unit unit NN cord-335975-m6lkrehi 1150 20 traineeship traineeship NN cord-335975-m6lkrehi 1150 21 and and CC cord-335975-m6lkrehi 1150 22 report report NN cord-335975-m6lkrehi 1150 23 of of IN cord-335975-m6lkrehi 1150 24 regular regular JJ cord-335975-m6lkrehi 1150 25 use use NN cord-335975-m6lkrehi 1150 26 of of IN cord-335975-m6lkrehi 1150 27 AHR AHR NNP cord-335975-m6lkrehi 1150 28 , , , cord-335975-m6lkrehi 1150 29 the the DT cord-335975-m6lkrehi 1150 30 hazard hazard NN cord-335975-m6lkrehi 1150 31 ratio ratio NN cord-335975-m6lkrehi 1150 32 for for IN cord-335975-m6lkrehi 1150 33 the the DT cord-335975-m6lkrehi 1150 34 intervention intervention NN cord-335975-m6lkrehi 1150 35 was be VBD cord-335975-m6lkrehi 1150 36 3.837 3.837 CD cord-335975-m6lkrehi 1151 1 ( ( -LRB- cord-335975-m6lkrehi 1151 2 IC IC NNP cord-335975-m6lkrehi 1151 3 2.086 2.086 NNP cord-335975-m6lkrehi 1151 4 - - HYPH cord-335975-m6lkrehi 1151 5 7.058 7.058 CD cord-335975-m6lkrehi 1151 6 ) ) -RRB- cord-335975-m6lkrehi 1151 7 . . . cord-335975-m6lkrehi 1152 1 The the DT cord-335975-m6lkrehi 1152 2 rate rate NN cord-335975-m6lkrehi 1152 3 of of IN cord-335975-m6lkrehi 1152 4 perfect perfect JJ cord-335975-m6lkrehi 1152 5 compliance compliance NN cord-335975-m6lkrehi 1152 6 with with IN cord-335975-m6lkrehi 1152 7 the the DT cord-335975-m6lkrehi 1152 8 HH HH NNP cord-335975-m6lkrehi 1152 9 opportunities opportunity NNS cord-335975-m6lkrehi 1152 10 in in IN cord-335975-m6lkrehi 1152 11 the the DT cord-335975-m6lkrehi 1152 12 intervention intervention NN cord-335975-m6lkrehi 1152 13 group group NN cord-335975-m6lkrehi 1152 14 was be VBD cord-335975-m6lkrehi 1152 15 increased increase VBN cord-335975-m6lkrehi 1152 16 ( ( -LRB- cord-335975-m6lkrehi 1152 17 58.1 58.1 CD cord-335975-m6lkrehi 1152 18 % % NN cord-335975-m6lkrehi 1152 19 versus versus IN cord-335975-m6lkrehi 1152 20 42.4 42.4 CD cord-335975-m6lkrehi 1152 21 % % NN cord-335975-m6lkrehi 1152 22 p p NN cord-335975-m6lkrehi 1152 23 < < XX cord-335975-m6lkrehi 1152 24 0.018 0.018 CD cord-335975-m6lkrehi 1152 25 ) ) -RRB- cord-335975-m6lkrehi 1152 26 and and CC cord-335975-m6lkrehi 1152 27 the the DT cord-335975-m6lkrehi 1152 28 effect effect NN cord-335975-m6lkrehi 1152 29 persisted persist VBD cord-335975-m6lkrehi 1152 30 in in IN cord-335975-m6lkrehi 1152 31 the the DT cord-335975-m6lkrehi 1152 32 logistic logistic JJ cord-335975-m6lkrehi 1152 33 regression regression NN cord-335975-m6lkrehi 1152 34 . . . cord-335975-m6lkrehi 1153 1 Conclusion conclusion NN cord-335975-m6lkrehi 1153 2 : : : cord-335975-m6lkrehi 1153 3 UV uv NN cord-335975-m6lkrehi 1153 4 cabinets cabinet NNS cord-335975-m6lkrehi 1153 5 for for IN cord-335975-m6lkrehi 1153 6 undergraduate undergraduate JJ cord-335975-m6lkrehi 1153 7 students student NNS cord-335975-m6lkrehi 1153 8 ' ' POS cord-335975-m6lkrehi 1153 9 HH HH NNP cord-335975-m6lkrehi 1153 10 education education NN cord-335975-m6lkrehi 1153 11 improve improve VB cord-335975-m6lkrehi 1153 12 the the DT cord-335975-m6lkrehi 1153 13 technique technique NN cord-335975-m6lkrehi 1153 14 and and CC cord-335975-m6lkrehi 1153 15 the the DT cord-335975-m6lkrehi 1153 16 compliance compliance NN cord-335975-m6lkrehi 1153 17 with with IN cord-335975-m6lkrehi 1153 18 HH HH NNP cord-335975-m6lkrehi 1153 19 opportunities opportunity NNS cord-335975-m6lkrehi 1153 20 . . . cord-335975-m6lkrehi 1154 1 Included include VBN cord-335975-m6lkrehi 1154 2 in in IN cord-335975-m6lkrehi 1154 3 a a DT cord-335975-m6lkrehi 1154 4 multifaceted multifaceted JJ cord-335975-m6lkrehi 1154 5 education education NN cord-335975-m6lkrehi 1154 6 program program NN cord-335975-m6lkrehi 1154 7 , , , cord-335975-m6lkrehi 1154 8 it -PRON- PRP cord-335975-m6lkrehi 1154 9 must must MD cord-335975-m6lkrehi 1154 10 be be VB cord-335975-m6lkrehi 1154 11 considered consider VBN cord-335975-m6lkrehi 1154 12 a a DT cord-335975-m6lkrehi 1154 13 key key JJ cord-335975-m6lkrehi 1154 14 tool tool NN cord-335975-m6lkrehi 1154 15 for for IN cord-335975-m6lkrehi 1154 16 training training NN cord-335975-m6lkrehi 1154 17 . . . cord-335975-m6lkrehi 1155 1 Results result NNS cord-335975-m6lkrehi 1155 2 : : : cord-335975-m6lkrehi 1156 1 Among among IN cord-335975-m6lkrehi 1156 2 the the DT cord-335975-m6lkrehi 1156 3 56 56 CD cord-335975-m6lkrehi 1156 4 patients patient NNS cord-335975-m6lkrehi 1156 5 who who WP cord-335975-m6lkrehi 1156 6 underwent undergo VBD cord-335975-m6lkrehi 1156 7 ECMO ECMO NNP cord-335975-m6lkrehi 1156 8 support support NN cord-335975-m6lkrehi 1156 9 for for IN cord-335975-m6lkrehi 1156 10 more more JJR cord-335975-m6lkrehi 1156 11 than than IN cord-335975-m6lkrehi 1156 12 48 48 CD cord-335975-m6lkrehi 1156 13 h h NN cord-335975-m6lkrehi 1156 14 , , , cord-335975-m6lkrehi 1156 15 the the DT cord-335975-m6lkrehi 1156 16 BSI BSI NNP cord-335975-m6lkrehi 1156 17 prevalence prevalence NN cord-335975-m6lkrehi 1156 18 was be VBD cord-335975-m6lkrehi 1156 19 27.4 27.4 CD cord-335975-m6lkrehi 1156 20 cases case NNS cord-335975-m6lkrehi 1156 21 per per IN cord-335975-m6lkrehi 1156 22 1000 1000 CD cord-335975-m6lkrehi 1156 23 ECMO ecmo NN cord-335975-m6lkrehi 1156 24 days day NNS cord-335975-m6lkrehi 1156 25 and and CC cord-335975-m6lkrehi 1156 26 microorganisms microorganism NNS cord-335975-m6lkrehi 1156 27 associated associate VBN cord-335975-m6lkrehi 1156 28 were be VBD cord-335975-m6lkrehi 1156 29 most most RBS cord-335975-m6lkrehi 1156 30 frequently frequently RB cord-335975-m6lkrehi 1156 31 gramnegative gramnegative JJ cord-335975-m6lkrehi 1156 32 bacilli bacilli JJ cord-335975-m6lkrehi 1156 33 . . . cord-335975-m6lkrehi 1157 1 As as IN cord-335975-m6lkrehi 1157 2 for for IN cord-335975-m6lkrehi 1157 3 positive positive JJ cord-335975-m6lkrehi 1157 4 TA TA NNP cord-335975-m6lkrehi 1157 5 cultures culture NNS cord-335975-m6lkrehi 1157 6 , , , cord-335975-m6lkrehi 1157 7 microorganisms microorganism NNS cord-335975-m6lkrehi 1157 8 associated associate VBN cord-335975-m6lkrehi 1157 9 were be VBD cord-335975-m6lkrehi 1157 10 oropharyngeal oropharyngeal JJ cord-335975-m6lkrehi 1157 11 germs germ NNS cord-335975-m6lkrehi 1157 12 and and CC cord-335975-m6lkrehi 1157 13 gram gram NN cord-335975-m6lkrehi 1157 14 - - HYPH cord-335975-m6lkrehi 1157 15 negative negative JJ cord-335975-m6lkrehi 1157 16 bacilli bacilli NN cord-335975-m6lkrehi 1157 17 . . . cord-335975-m6lkrehi 1158 1 Two two CD cord-335975-m6lkrehi 1158 2 risk risk NN cord-335975-m6lkrehi 1158 3 factors factor NNS cord-335975-m6lkrehi 1158 4 were be VBD cord-335975-m6lkrehi 1158 5 associated associate VBN cord-335975-m6lkrehi 1158 6 with with IN cord-335975-m6lkrehi 1158 7 nosocomial nosocomial JJ cord-335975-m6lkrehi 1158 8 bacteria bacteria NNS cord-335975-m6lkrehi 1158 9 occurrence occurrence NN cord-335975-m6lkrehi 1158 10 in in IN cord-335975-m6lkrehi 1158 11 TA TA NNP cord-335975-m6lkrehi 1158 12 cultures culture NNS cord-335975-m6lkrehi 1158 13 - - : cord-335975-m6lkrehi 1158 14 prior prior JJ cord-335975-m6lkrehi 1158 15 antibiotics antibiotic NNS cord-335975-m6lkrehi 1158 16 and and CC cord-335975-m6lkrehi 1158 17 duration duration NN cord-335975-m6lkrehi 1158 18 of of IN cord-335975-m6lkrehi 1158 19 mechanical mechanical JJ cord-335975-m6lkrehi 1158 20 ventilation ventilation NN cord-335975-m6lkrehi 1158 21 more more JJR cord-335975-m6lkrehi 1158 22 than than IN cord-335975-m6lkrehi 1158 23 5 5 CD cord-335975-m6lkrehi 1158 24 days day NNS cord-335975-m6lkrehi 1158 25 . . . cord-335975-m6lkrehi 1159 1 We -PRON- PRP cord-335975-m6lkrehi 1159 2 demonstrated demonstrate VBD cord-335975-m6lkrehi 1159 3 a a DT cord-335975-m6lkrehi 1159 4 link link NN cord-335975-m6lkrehi 1159 5 between between IN cord-335975-m6lkrehi 1159 6 " " `` cord-335975-m6lkrehi 1159 7 positive positive JJ cord-335975-m6lkrehi 1159 8 TA TA NNP cord-335975-m6lkrehi 1159 9 culture culture NN cord-335975-m6lkrehi 1159 10 " " '' cord-335975-m6lkrehi 1159 11 and and CC cord-335975-m6lkrehi 1159 12 " " `` cord-335975-m6lkrehi 1159 13 positive positive JJ cord-335975-m6lkrehi 1159 14 blood blood NN cord-335975-m6lkrehi 1159 15 culture culture NN cord-335975-m6lkrehi 1159 16 " " '' cord-335975-m6lkrehi 1159 17 and and CC cord-335975-m6lkrehi 1159 18 we -PRON- PRP cord-335975-m6lkrehi 1159 19 showed show VBD cord-335975-m6lkrehi 1159 20 a a DT cord-335975-m6lkrehi 1159 21 protective protective JJ cord-335975-m6lkrehi 1159 22 effect effect NN cord-335975-m6lkrehi 1159 23 of of IN cord-335975-m6lkrehi 1159 24 using use VBG cord-335975-m6lkrehi 1159 25 an an DT cord-335975-m6lkrehi 1159 26 antibioprophylaxis antibioprophylaxis NN cord-335975-m6lkrehi 1159 27 on on IN cord-335975-m6lkrehi 1159 28 " " `` cord-335975-m6lkrehi 1159 29 positive positive JJ cord-335975-m6lkrehi 1159 30 TA TA NNP cord-335975-m6lkrehi 1159 31 culture culture NN cord-335975-m6lkrehi 1159 32 " " '' cord-335975-m6lkrehi 1159 33 and and CC cord-335975-m6lkrehi 1159 34 " " `` cord-335975-m6lkrehi 1159 35 global global JJ cord-335975-m6lkrehi 1159 36 positive positive JJ cord-335975-m6lkrehi 1159 37 cultures culture NNS cord-335975-m6lkrehi 1159 38 " " '' cord-335975-m6lkrehi 1159 39 development development NN cord-335975-m6lkrehi 1159 40 . . . cord-335975-m6lkrehi 1160 1 Introduction introduction NN cord-335975-m6lkrehi 1160 2 : : : cord-335975-m6lkrehi 1161 1 Delirium delirium NN cord-335975-m6lkrehi 1161 2 in in IN cord-335975-m6lkrehi 1161 3 the the DT cord-335975-m6lkrehi 1161 4 ICU ICU NNP cord-335975-m6lkrehi 1161 5 is be VBZ cord-335975-m6lkrehi 1161 6 often often RB cord-335975-m6lkrehi 1161 7 under under RB cord-335975-m6lkrehi 1161 8 - - HYPH cord-335975-m6lkrehi 1161 9 diagnosed diagnose VBN cord-335975-m6lkrehi 1161 10 despite despite IN cord-335975-m6lkrehi 1161 11 its -PRON- PRP$ cord-335975-m6lkrehi 1161 12 related related JJ cord-335975-m6lkrehi 1161 13 burden burden NN cord-335975-m6lkrehi 1161 14 and and CC cord-335975-m6lkrehi 1161 15 impact impact NN cord-335975-m6lkrehi 1161 16 on on IN cord-335975-m6lkrehi 1161 17 patients patient NNS cord-335975-m6lkrehi 1161 18 ' ' POS cord-335975-m6lkrehi 1161 19 morbidity morbidity NN cord-335975-m6lkrehi 1161 20 , , , cord-335975-m6lkrehi 1161 21 mortality mortality NN cord-335975-m6lkrehi 1161 22 and and CC cord-335975-m6lkrehi 1161 23 prolongation prolongation NN cord-335975-m6lkrehi 1161 24 of of IN cord-335975-m6lkrehi 1161 25 hospital hospital NN cord-335975-m6lkrehi 1161 26 length length NN cord-335975-m6lkrehi 1161 27 of of IN cord-335975-m6lkrehi 1161 28 stay stay NN cord-335975-m6lkrehi 1161 29 . . . cord-335975-m6lkrehi 1162 1 The the DT cord-335975-m6lkrehi 1162 2 aim aim NN cord-335975-m6lkrehi 1162 3 of of IN cord-335975-m6lkrehi 1162 4 this this DT cord-335975-m6lkrehi 1162 5 study study NN cord-335975-m6lkrehi 1162 6 was be VBD cord-335975-m6lkrehi 1162 7 to to TO cord-335975-m6lkrehi 1162 8 assess assess VB cord-335975-m6lkrehi 1162 9 the the DT cord-335975-m6lkrehi 1162 10 medical medical JJ cord-335975-m6lkrehi 1162 11 and and CC cord-335975-m6lkrehi 1162 12 paramedical paramedical JJ cord-335975-m6lkrehi 1162 13 community community NN cord-335975-m6lkrehi 1162 14 beliefs belief NNS cord-335975-m6lkrehi 1162 15 and and CC cord-335975-m6lkrehi 1162 16 practices practice NNS cord-335975-m6lkrehi 1162 17 regarding regard VBG cord-335975-m6lkrehi 1162 18 delirium delirium NN cord-335975-m6lkrehi 1162 19 in in IN cord-335975-m6lkrehi 1162 20 Tunisian tunisian JJ cord-335975-m6lkrehi 1162 21 ICUs icu NNS cord-335975-m6lkrehi 1162 22 . . . cord-335975-m6lkrehi 1163 1 Patients patient NNS cord-335975-m6lkrehi 1163 2 and and CC cord-335975-m6lkrehi 1163 3 methods method NNS cord-335975-m6lkrehi 1163 4 : : : cord-335975-m6lkrehi 1163 5 Between between IN cord-335975-m6lkrehi 1163 6 August August NNP cord-335975-m6lkrehi 1163 7 1st 1st NN cord-335975-m6lkrehi 1163 8 and and CC cord-335975-m6lkrehi 1163 9 31/2017 31/2017 CD cord-335975-m6lkrehi 1163 10 , , , cord-335975-m6lkrehi 1163 11 healthcare healthcare NN cord-335975-m6lkrehi 1163 12 professionals professional NNS cord-335975-m6lkrehi 1163 13 working work VBG cord-335975-m6lkrehi 1163 14 at at IN cord-335975-m6lkrehi 1163 15 the the DT cord-335975-m6lkrehi 1163 16 ICUs ICUs NNP cord-335975-m6lkrehi 1163 17 of of IN cord-335975-m6lkrehi 1163 18 university university NN cord-335975-m6lkrehi 1163 19 hospitals hospital NNS cord-335975-m6lkrehi 1163 20 of of IN cord-335975-m6lkrehi 1163 21 Monastir Monastir NNP cord-335975-m6lkrehi 1163 22 and and CC cord-335975-m6lkrehi 1163 23 Mahdia Mahdia NNP cord-335975-m6lkrehi 1163 24 ( ( -LRB- cord-335975-m6lkrehi 1163 25 Tunisia Tunisia NNP cord-335975-m6lkrehi 1163 26 ) ) -RRB- cord-335975-m6lkrehi 1163 27 were be VBD cord-335975-m6lkrehi 1163 28 asked ask VBN cord-335975-m6lkrehi 1163 29 to to TO cord-335975-m6lkrehi 1163 30 participate participate VB cord-335975-m6lkrehi 1163 31 in in IN cord-335975-m6lkrehi 1163 32 the the DT cord-335975-m6lkrehi 1163 33 survey survey NN cord-335975-m6lkrehi 1163 34 by by IN cord-335975-m6lkrehi 1163 35 completing complete VBG cord-335975-m6lkrehi 1163 36 a a DT cord-335975-m6lkrehi 1163 37 questionnaire questionnaire NN cord-335975-m6lkrehi 1163 38 anonymously anonymously RB cord-335975-m6lkrehi 1163 39 ( ( -LRB- cord-335975-m6lkrehi 1163 40 that that IN cord-335975-m6lkrehi 1163 41 specified specify VBN cord-335975-m6lkrehi 1163 42 participants participant NNS cord-335975-m6lkrehi 1163 43 ' ' POS cord-335975-m6lkrehi 1163 44 characteristics characteristic NNS cord-335975-m6lkrehi 1163 45 ( ( -LRB- cord-335975-m6lkrehi 1163 46 age age NN cord-335975-m6lkrehi 1163 47 , , , cord-335975-m6lkrehi 1163 48 gender gender NN cord-335975-m6lkrehi 1163 49 , , , cord-335975-m6lkrehi 1163 50 function function NN cord-335975-m6lkrehi 1163 51 , , , cord-335975-m6lkrehi 1163 52 years year NNS cord-335975-m6lkrehi 1163 53 of of IN cord-335975-m6lkrehi 1163 54 experience experience NN cord-335975-m6lkrehi 1163 55 in in IN cord-335975-m6lkrehi 1163 56 ICU ICU NNP cord-335975-m6lkrehi 1163 57 ) ) -RRB- cord-335975-m6lkrehi 1163 58 and and CC cord-335975-m6lkrehi 1163 59 their -PRON- PRP$ cord-335975-m6lkrehi 1163 60 knowledge knowledge NN cord-335975-m6lkrehi 1163 61 and and CC cord-335975-m6lkrehi 1163 62 perception perception NN cord-335975-m6lkrehi 1163 63 of of IN cord-335975-m6lkrehi 1163 64 delirium delirium NN cord-335975-m6lkrehi 1163 65 in in IN cord-335975-m6lkrehi 1163 66 ICU ICU NNP cord-335975-m6lkrehi 1163 67 . . . cord-335975-m6lkrehi 1164 1 The the DT cord-335975-m6lkrehi 1164 2 questionnaire questionnaire NN cord-335975-m6lkrehi 1164 3 consisted consist VBD cord-335975-m6lkrehi 1164 4 in in IN cord-335975-m6lkrehi 1164 5 10 10 CD cord-335975-m6lkrehi 1164 6 questions question NNS cord-335975-m6lkrehi 1164 7 of of IN cord-335975-m6lkrehi 1164 8 different different JJ cord-335975-m6lkrehi 1164 9 types type NNS cord-335975-m6lkrehi 1164 10 : : : cord-335975-m6lkrehi 1164 11 Likert Likert NNP cord-335975-m6lkrehi 1164 12 style style NN cord-335975-m6lkrehi 1164 13 (: (: IN cord-335975-m6lkrehi 1164 14 widespread widespread JJ cord-335975-m6lkrehi 1164 15 scale scale NN cord-335975-m6lkrehi 1164 16 in in IN cord-335975-m6lkrehi 1164 17 psychometric psychometric JJ cord-335975-m6lkrehi 1164 18 questionnaires questionnaire NNS cord-335975-m6lkrehi 1164 19 in in IN cord-335975-m6lkrehi 1164 20 which which WDT cord-335975-m6lkrehi 1164 21 the the DT cord-335975-m6lkrehi 1164 22 respondent respondent NN cord-335975-m6lkrehi 1164 23 expresses express VBZ cord-335975-m6lkrehi 1164 24 his -PRON- PRP$ cord-335975-m6lkrehi 1164 25 or or CC cord-335975-m6lkrehi 1164 26 her -PRON- PRP$ cord-335975-m6lkrehi 1164 27 degree degree NN cord-335975-m6lkrehi 1164 28 of of IN cord-335975-m6lkrehi 1164 29 agreement agreement NN cord-335975-m6lkrehi 1164 30 or or CC cord-335975-m6lkrehi 1164 31 disagreement disagreement NN cord-335975-m6lkrehi 1164 32 with with IN cord-335975-m6lkrehi 1164 33 an an DT cord-335975-m6lkrehi 1164 34 assertion assertion NN cord-335975-m6lkrehi 1164 35 ) ) -RRB- cord-335975-m6lkrehi 1164 36 , , , cord-335975-m6lkrehi 1164 37 multiple multiple JJ cord-335975-m6lkrehi 1164 38 choice choice NN cord-335975-m6lkrehi 1164 39 , , , cord-335975-m6lkrehi 1164 40 ranking ranking NN cord-335975-m6lkrehi 1164 41 and and CC cord-335975-m6lkrehi 1164 42 yes yes UH cord-335975-m6lkrehi 1164 43 / / SYM cord-335975-m6lkrehi 1164 44 no no UH cord-335975-m6lkrehi 1164 45 ) ) -RRB- cord-335975-m6lkrehi 1164 46 . . . cord-335975-m6lkrehi 1165 1 Results result NNS cord-335975-m6lkrehi 1165 2 : : : cord-335975-m6lkrehi 1166 1 During during IN cord-335975-m6lkrehi 1166 2 the the DT cord-335975-m6lkrehi 1166 3 study study NN cord-335975-m6lkrehi 1166 4 period period NN cord-335975-m6lkrehi 1166 5 , , , cord-335975-m6lkrehi 1166 6 96 96 CD cord-335975-m6lkrehi 1166 7 respondents respondent NNS cord-335975-m6lkrehi 1166 8 out out IN cord-335975-m6lkrehi 1166 9 of of IN cord-335975-m6lkrehi 1166 10 163 163 CD cord-335975-m6lkrehi 1166 11 ( ( -LRB- cord-335975-m6lkrehi 1166 12 60 60 CD cord-335975-m6lkrehi 1166 13 % % NN cord-335975-m6lkrehi 1166 14 female female NN cord-335975-m6lkrehi 1166 15 , , , cord-335975-m6lkrehi 1166 16 nurses nurse NNS cord-335975-m6lkrehi 1166 17 : : : cord-335975-m6lkrehi 1166 18 52 52 CD cord-335975-m6lkrehi 1166 19 % % NN cord-335975-m6lkrehi 1166 20 ) ) -RRB- cord-335975-m6lkrehi 1166 21 , , , cord-335975-m6lkrehi 1166 22 aged age VBN cord-335975-m6lkrehi 1166 23 between between IN cord-335975-m6lkrehi 1166 24 20 20 CD cord-335975-m6lkrehi 1166 25 - - SYM cord-335975-m6lkrehi 1166 26 30 30 CD cord-335975-m6lkrehi 1166 27 years year NNS cord-335975-m6lkrehi 1166 28 in in IN cord-335975-m6lkrehi 1166 29 70 70 CD cord-335975-m6lkrehi 1166 30 % % NN cord-335975-m6lkrehi 1166 31 , , , cord-335975-m6lkrehi 1166 32 responded respond VBD cord-335975-m6lkrehi 1166 33 to to IN cord-335975-m6lkrehi 1166 34 the the DT cord-335975-m6lkrehi 1166 35 questionnaire questionnaire NN cord-335975-m6lkrehi 1166 36 . . . cord-335975-m6lkrehi 1167 1 Healthcare healthcare NN cord-335975-m6lkrehi 1167 2 professionals professional NNS cord-335975-m6lkrehi 1167 3 experience experience VBP cord-335975-m6lkrehi 1167 4 in in IN cord-335975-m6lkrehi 1167 5 the the DT cord-335975-m6lkrehi 1167 6 ICU ICU NNP cord-335975-m6lkrehi 1167 7 was be VBD cord-335975-m6lkrehi 1167 8 < < NNP cord-335975-m6lkrehi 1167 9 1 1 CD cord-335975-m6lkrehi 1167 10 year year NN cord-335975-m6lkrehi 1167 11 in in IN cord-335975-m6lkrehi 1167 12 39.6 39.6 CD cord-335975-m6lkrehi 1167 13 % % NN cord-335975-m6lkrehi 1167 14 ; ; : cord-335975-m6lkrehi 1167 15 1 1 CD cord-335975-m6lkrehi 1167 16 - - SYM cord-335975-m6lkrehi 1167 17 5 5 CD cord-335975-m6lkrehi 1167 18 years year NNS cord-335975-m6lkrehi 1167 19 in in IN cord-335975-m6lkrehi 1167 20 32.3 32.3 CD cord-335975-m6lkrehi 1167 21 % % NN cord-335975-m6lkrehi 1167 22 , , , cord-335975-m6lkrehi 1167 23 and and CC cord-335975-m6lkrehi 1167 24 > > XX cord-335975-m6lkrehi 1167 25 5 5 CD cord-335975-m6lkrehi 1167 26 years year NNS cord-335975-m6lkrehi 1167 27 in in IN cord-335975-m6lkrehi 1167 28 28.1 28.1 CD cord-335975-m6lkrehi 1167 29 % % NN cord-335975-m6lkrehi 1167 30 . . . cord-335975-m6lkrehi 1168 1 Participants participant NNS cord-335975-m6lkrehi 1168 2 asserted assert VBD cord-335975-m6lkrehi 1168 3 that that IN cord-335975-m6lkrehi 1168 4 the the DT cord-335975-m6lkrehi 1168 5 " " `` cord-335975-m6lkrehi 1168 6 most most RBS cord-335975-m6lkrehi 1168 7 characteristic characteristic JJ cord-335975-m6lkrehi 1168 8 signs sign NNS cord-335975-m6lkrehi 1168 9 of of IN cord-335975-m6lkrehi 1168 10 delirium delirium NN cord-335975-m6lkrehi 1168 11 " " '' cord-335975-m6lkrehi 1168 12 were be VBD cord-335975-m6lkrehi 1168 13 : : : cord-335975-m6lkrehi 1168 14 insomnia insomnia NN cord-335975-m6lkrehi 1168 15 ( ( -LRB- cord-335975-m6lkrehi 1168 16 25 25 CD cord-335975-m6lkrehi 1168 17 % % NN cord-335975-m6lkrehi 1168 18 ) ) -RRB- cord-335975-m6lkrehi 1168 19 ; ; : cord-335975-m6lkrehi 1168 20 confusion confusion NN cord-335975-m6lkrehi 1168 21 ( ( -LRB- cord-335975-m6lkrehi 1168 22 22 22 CD cord-335975-m6lkrehi 1168 23 % % NN cord-335975-m6lkrehi 1168 24 ) ) -RRB- cord-335975-m6lkrehi 1168 25 ; ; : cord-335975-m6lkrehi 1168 26 agitation agitation NN cord-335975-m6lkrehi 1168 27 ( ( -LRB- cord-335975-m6lkrehi 1168 28 21 21 CD cord-335975-m6lkrehi 1168 29 % % NN cord-335975-m6lkrehi 1168 30 ) ) -RRB- cord-335975-m6lkrehi 1168 31 and and CC cord-335975-m6lkrehi 1168 32 aggressiveness aggressiveness NN cord-335975-m6lkrehi 1168 33 ( ( -LRB- cord-335975-m6lkrehi 1168 34 20 20 CD cord-335975-m6lkrehi 1168 35 % % NN cord-335975-m6lkrehi 1168 36 ) ) -RRB- cord-335975-m6lkrehi 1168 37 . . . cord-335975-m6lkrehi 1169 1 Three three CD cord-335975-m6lkrehi 1169 2 - - HYPH cord-335975-m6lkrehi 1169 3 quarters quarter NNS cord-335975-m6lkrehi 1169 4 of of IN cord-335975-m6lkrehi 1169 5 participants participant NNS cord-335975-m6lkrehi 1169 6 said say VBD cord-335975-m6lkrehi 1169 7 they -PRON- PRP cord-335975-m6lkrehi 1169 8 did do VBD cord-335975-m6lkrehi 1169 9 not not RB cord-335975-m6lkrehi 1169 10 systematically systematically RB cord-335975-m6lkrehi 1169 11 search search VB cord-335975-m6lkrehi 1169 12 for for IN cord-335975-m6lkrehi 1169 13 signs sign NNS cord-335975-m6lkrehi 1169 14 of of IN cord-335975-m6lkrehi 1169 15 delirium delirium NN cord-335975-m6lkrehi 1169 16 in in IN cord-335975-m6lkrehi 1169 17 their -PRON- PRP$ cord-335975-m6lkrehi 1169 18 patients patient NNS cord-335975-m6lkrehi 1169 19 . . . cord-335975-m6lkrehi 1170 1 33 33 CD cord-335975-m6lkrehi 1170 2 % % NN cord-335975-m6lkrehi 1170 3 thought think VBD cord-335975-m6lkrehi 1170 4 that that IN cord-335975-m6lkrehi 1170 5 delirium delirium NN cord-335975-m6lkrehi 1170 6 was be VBD cord-335975-m6lkrehi 1170 7 " " `` cord-335975-m6lkrehi 1170 8 an an DT cord-335975-m6lkrehi 1170 9 insignificant insignificant JJ cord-335975-m6lkrehi 1170 10 problem problem NN cord-335975-m6lkrehi 1170 11 " " '' cord-335975-m6lkrehi 1170 12 or or CC cord-335975-m6lkrehi 1170 13 that that IN cord-335975-m6lkrehi 1170 14 " " `` cord-335975-m6lkrehi 1170 15 it -PRON- PRP cord-335975-m6lkrehi 1170 16 was be VBD cord-335975-m6lkrehi 1170 17 not not RB cord-335975-m6lkrehi 1170 18 a a DT cord-335975-m6lkrehi 1170 19 problem problem NN cord-335975-m6lkrehi 1170 20 " " '' cord-335975-m6lkrehi 1170 21 . . . cord-335975-m6lkrehi 1171 1 Only only RB cord-335975-m6lkrehi 1171 2 one one CD cord-335975-m6lkrehi 1171 3 and and CC cord-335975-m6lkrehi 1171 4 three three CD cord-335975-m6lkrehi 1171 5 participants participant NNS cord-335975-m6lkrehi 1171 6 respectively respectively RB cord-335975-m6lkrehi 1171 7 , , , cord-335975-m6lkrehi 1171 8 said say VBD cord-335975-m6lkrehi 1171 9 they -PRON- PRP cord-335975-m6lkrehi 1171 10 attended attend VBD cord-335975-m6lkrehi 1171 11 a a DT cord-335975-m6lkrehi 1171 12 conference conference NN cord-335975-m6lkrehi 1171 13 and and CC cord-335975-m6lkrehi 1171 14 read read VB cord-335975-m6lkrehi 1171 15 an an DT cord-335975-m6lkrehi 1171 16 article article NN cord-335975-m6lkrehi 1171 17 about about IN cord-335975-m6lkrehi 1171 18 delirium delirium NN cord-335975-m6lkrehi 1171 19 in in IN cord-335975-m6lkrehi 1171 20 ICU ICU NNP cord-335975-m6lkrehi 1171 21 the the DT cord-335975-m6lkrehi 1171 22 last last JJ cord-335975-m6lkrehi 1171 23 year year NN cord-335975-m6lkrehi 1171 24 . . . cord-335975-m6lkrehi 1172 1 Half half NN cord-335975-m6lkrehi 1172 2 of of IN cord-335975-m6lkrehi 1172 3 the the DT cord-335975-m6lkrehi 1172 4 respondents respondent NNS cord-335975-m6lkrehi 1172 5 felt feel VBD cord-335975-m6lkrehi 1172 6 that that IN cord-335975-m6lkrehi 1172 7 the the DT cord-335975-m6lkrehi 1172 8 most most RBS cord-335975-m6lkrehi 1172 9 appropriate appropriate JJ cord-335975-m6lkrehi 1172 10 treatment treatment NN cord-335975-m6lkrehi 1172 11 for for IN cord-335975-m6lkrehi 1172 12 a a DT cord-335975-m6lkrehi 1172 13 patient patient NN cord-335975-m6lkrehi 1172 14 with with IN cord-335975-m6lkrehi 1172 15 delirium delirium NN cord-335975-m6lkrehi 1172 16 was be VBD cord-335975-m6lkrehi 1172 17 restraint restraint NN cord-335975-m6lkrehi 1172 18 . . . cord-335975-m6lkrehi 1173 1 Nearly nearly RB cord-335975-m6lkrehi 1173 2 one one CD cord-335975-m6lkrehi 1173 3 - - HYPH cord-335975-m6lkrehi 1173 4 third third NN cord-335975-m6lkrehi 1173 5 of of IN cord-335975-m6lkrehi 1173 6 participants participant NNS cord-335975-m6lkrehi 1173 7 thought think VBD cord-335975-m6lkrehi 1173 8 that that IN cord-335975-m6lkrehi 1173 9 delirium delirium NN cord-335975-m6lkrehi 1173 10 was be VBD cord-335975-m6lkrehi 1173 11 an an DT cord-335975-m6lkrehi 1173 12 under under RB cord-335975-m6lkrehi 1173 13 - - HYPH cord-335975-m6lkrehi 1173 14 diagnosed diagnose VBN cord-335975-m6lkrehi 1173 15 entity entity NN cord-335975-m6lkrehi 1173 16 and and CC cord-335975-m6lkrehi 1173 17 only only RB cord-335975-m6lkrehi 1173 18 6 6 CD cord-335975-m6lkrehi 1173 19 % % NN cord-335975-m6lkrehi 1173 20 felt feel VBD cord-335975-m6lkrehi 1173 21 that that IN cord-335975-m6lkrehi 1173 22 it -PRON- PRP cord-335975-m6lkrehi 1173 23 was be VBD cord-335975-m6lkrehi 1173 24 associated associate VBN cord-335975-m6lkrehi 1173 25 with with IN cord-335975-m6lkrehi 1173 26 long long JJ cord-335975-m6lkrehi 1173 27 - - HYPH cord-335975-m6lkrehi 1173 28 term term NN cord-335975-m6lkrehi 1173 29 neuropsychological neuropsychological JJ cord-335975-m6lkrehi 1173 30 deficits deficit NNS cord-335975-m6lkrehi 1173 31 . . . cord-335975-m6lkrehi 1174 1 Factors factor NNS cord-335975-m6lkrehi 1174 2 considered consider VBN cord-335975-m6lkrehi 1174 3 to to TO cord-335975-m6lkrehi 1174 4 be be VB cord-335975-m6lkrehi 1174 5 determinant determinant JJ cord-335975-m6lkrehi 1174 6 in in IN cord-335975-m6lkrehi 1174 7 the the DT cord-335975-m6lkrehi 1174 8 occurrence occurrence NN cord-335975-m6lkrehi 1174 9 of of IN cord-335975-m6lkrehi 1174 10 delirium delirium NN cord-335975-m6lkrehi 1174 11 were be VBD cord-335975-m6lkrehi 1174 12 ARDS ARDS NNP cord-335975-m6lkrehi 1174 13 , , , cord-335975-m6lkrehi 1174 14 shock shock NN cord-335975-m6lkrehi 1174 15 , , , cord-335975-m6lkrehi 1174 16 age age NN cord-335975-m6lkrehi 1174 17 , , , cord-335975-m6lkrehi 1174 18 mechanical mechanical JJ cord-335975-m6lkrehi 1174 19 ventilation ventilation NN cord-335975-m6lkrehi 1174 20 , , , cord-335975-m6lkrehi 1174 21 postoperative postoperative JJ cord-335975-m6lkrehi 1174 22 status status NN cord-335975-m6lkrehi 1174 23 in in IN cord-335975-m6lkrehi 1174 24 70 70 CD cord-335975-m6lkrehi 1174 25 , , , cord-335975-m6lkrehi 1174 26 66 66 CD cord-335975-m6lkrehi 1174 27 , , , cord-335975-m6lkrehi 1174 28 63 63 CD cord-335975-m6lkrehi 1174 29 , , , cord-335975-m6lkrehi 1174 30 55 55 CD cord-335975-m6lkrehi 1174 31 and and CC cord-335975-m6lkrehi 1174 32 17 17 CD cord-335975-m6lkrehi 1174 33 % % NN cord-335975-m6lkrehi 1174 34 , , , cord-335975-m6lkrehi 1174 35 respectively respectively RB cord-335975-m6lkrehi 1174 36 . . . cord-335975-m6lkrehi 1175 1 Conclusion conclusion NN cord-335975-m6lkrehi 1175 2 : : : cord-335975-m6lkrehi 1176 1 Most Most JJS cord-335975-m6lkrehi 1176 2 Tunisian tunisian JJ cord-335975-m6lkrehi 1176 3 healthcare healthcare NN cord-335975-m6lkrehi 1176 4 professionals professional NNS cord-335975-m6lkrehi 1176 5 consider consider VBP cord-335975-m6lkrehi 1176 6 delirium delirium NN cord-335975-m6lkrehi 1176 7 as as IN cord-335975-m6lkrehi 1176 8 a a DT cord-335975-m6lkrehi 1176 9 common common JJ cord-335975-m6lkrehi 1176 10 , , , cord-335975-m6lkrehi 1176 11 underdiagnosed underdiagnosed JJ cord-335975-m6lkrehi 1176 12 , , , cord-335975-m6lkrehi 1176 13 and and CC cord-335975-m6lkrehi 1176 14 serious serious JJ cord-335975-m6lkrehi 1176 15 problem problem NN cord-335975-m6lkrehi 1176 16 in in IN cord-335975-m6lkrehi 1176 17 the the DT cord-335975-m6lkrehi 1176 18 ICU ICU NNP cord-335975-m6lkrehi 1176 19 . . . cord-335975-m6lkrehi 1177 1 Yet yet RB cord-335975-m6lkrehi 1177 2 , , , cord-335975-m6lkrehi 1177 3 few few JJ cord-335975-m6lkrehi 1177 4 participants participant NNS cord-335975-m6lkrehi 1177 5 actually actually RB cord-335975-m6lkrehi 1177 6 monitor monitor VBP cord-335975-m6lkrehi 1177 7 this this DT cord-335975-m6lkrehi 1177 8 condition condition NN cord-335975-m6lkrehi 1177 9 . . . cord-335975-m6lkrehi 1178 1 The the DT cord-335975-m6lkrehi 1178 2 influence influence NN cord-335975-m6lkrehi 1178 3 of of IN cord-335975-m6lkrehi 1178 4 sedation sedation NN cord-335975-m6lkrehi 1178 5 choice choice NN cord-335975-m6lkrehi 1178 6 on on IN cord-335975-m6lkrehi 1178 7 the the DT cord-335975-m6lkrehi 1178 8 delirium delirium NN cord-335975-m6lkrehi 1178 9 occurrence occurrence NN cord-335975-m6lkrehi 1178 10 in in IN cord-335975-m6lkrehi 1178 11 critically critically RB cord-335975-m6lkrehi 1178 12 ill ill RB cord-335975-m6lkrehi 1178 13 poisoned poison VBN cord-335975-m6lkrehi 1178 14 patients patient NNS cord-335975-m6lkrehi 1178 15 : : : cord-335975-m6lkrehi 1178 16 a a DT cord-335975-m6lkrehi 1178 17 randomized randomized JJ cord-335975-m6lkrehi 1178 18 controlled control VBN cord-335975-m6lkrehi 1178 19 trial trial NN cord-335975-m6lkrehi 1178 20 Khzouri Khzouri NNP cord-335975-m6lkrehi 1178 21 Takoua Takoua NNP cord-335975-m6lkrehi 1178 22 Introduction Introduction NNP cord-335975-m6lkrehi 1178 23 : : : cord-335975-m6lkrehi 1178 24 Delirium delirium NN cord-335975-m6lkrehi 1178 25 is be VBZ cord-335975-m6lkrehi 1178 26 a a DT cord-335975-m6lkrehi 1178 27 common common JJ cord-335975-m6lkrehi 1178 28 manifestation manifestation NN cord-335975-m6lkrehi 1178 29 of of IN cord-335975-m6lkrehi 1178 30 acute acute JJ cord-335975-m6lkrehi 1178 31 brain brain NN cord-335975-m6lkrehi 1178 32 dysfunction dysfunction NN cord-335975-m6lkrehi 1178 33 in in IN cord-335975-m6lkrehi 1178 34 critically critically RB cord-335975-m6lkrehi 1178 35 ill ill JJ cord-335975-m6lkrehi 1178 36 patients patient NNS cord-335975-m6lkrehi 1178 37 . . . cord-335975-m6lkrehi 1179 1 It -PRON- PRP cord-335975-m6lkrehi 1179 2 is be VBZ cord-335975-m6lkrehi 1179 3 associated associate VBN cord-335975-m6lkrehi 1179 4 with with IN cord-335975-m6lkrehi 1179 5 a a DT cord-335975-m6lkrehi 1179 6 healthcare healthcare NN cord-335975-m6lkrehi 1179 7 cost cost NN cord-335975-m6lkrehi 1179 8 increase increase NN cord-335975-m6lkrehi 1179 9 , , , cord-335975-m6lkrehi 1179 10 and and CC cord-335975-m6lkrehi 1179 11 extension extension NN cord-335975-m6lkrehi 1179 12 of of IN cord-335975-m6lkrehi 1179 13 the the DT cord-335975-m6lkrehi 1179 14 hospital hospital NN cord-335975-m6lkrehi 1179 15 stay stay NN cord-335975-m6lkrehi 1179 16 length length NN cord-335975-m6lkrehi 1179 17 . . . cord-335975-m6lkrehi 1180 1 The the DT cord-335975-m6lkrehi 1180 2 present present JJ cord-335975-m6lkrehi 1180 3 study study NN cord-335975-m6lkrehi 1180 4 aimed aim VBN cord-335975-m6lkrehi 1180 5 to to TO cord-335975-m6lkrehi 1180 6 explore explore VB cord-335975-m6lkrehi 1180 7 influence influence NN cord-335975-m6lkrehi 1180 8 of of IN cord-335975-m6lkrehi 1180 9 patient patient JJ cord-335975-m6lkrehi 1180 10 characteristics characteristic NNS cord-335975-m6lkrehi 1180 11 and and CC cord-335975-m6lkrehi 1180 12 analgesicsedation analgesicsedation NN cord-335975-m6lkrehi 1180 13 on on IN cord-335975-m6lkrehi 1180 14 delirium delirium NN cord-335975-m6lkrehi 1180 15 incidence incidence NN cord-335975-m6lkrehi 1180 16 and and CC cord-335975-m6lkrehi 1180 17 to to TO cord-335975-m6lkrehi 1180 18 analyze analyze VB cord-335975-m6lkrehi 1180 19 its -PRON- PRP$ cord-335975-m6lkrehi 1180 20 risk risk NN cord-335975-m6lkrehi 1180 21 factors factor NNS cord-335975-m6lkrehi 1180 22 . . . cord-335975-m6lkrehi 1181 1 Patients patient NNS cord-335975-m6lkrehi 1181 2 and and CC cord-335975-m6lkrehi 1181 3 methods method NNS cord-335975-m6lkrehi 1182 1 : : : cord-335975-m6lkrehi 1182 2 It -PRON- PRP cord-335975-m6lkrehi 1182 3 is be VBZ cord-335975-m6lkrehi 1182 4 a a DT cord-335975-m6lkrehi 1182 5 prospective prospective JJ cord-335975-m6lkrehi 1182 6 single single JJ cord-335975-m6lkrehi 1182 7 blind blind NN cord-335975-m6lkrehi 1182 8 randomized randomized JJ cord-335975-m6lkrehi 1182 9 controlled control VBN cord-335975-m6lkrehi 1182 10 trial trial NN cord-335975-m6lkrehi 1182 11 , , , cord-335975-m6lkrehi 1182 12 started start VBD cord-335975-m6lkrehi 1182 13 on on IN cord-335975-m6lkrehi 1182 14 the the DT cord-335975-m6lkrehi 1182 15 first first JJ cord-335975-m6lkrehi 1182 16 July July NNP cord-335975-m6lkrehi 1182 17 2017 2017 CD cord-335975-m6lkrehi 1182 18 in in IN cord-335975-m6lkrehi 1182 19 a a DT cord-335975-m6lkrehi 1182 20 12-bed 12-bed CD cord-335975-m6lkrehi 1182 21 toxicological toxicological JJ cord-335975-m6lkrehi 1182 22 Intensive Intensive NNP cord-335975-m6lkrehi 1182 23 Care Care NNP cord-335975-m6lkrehi 1182 24 Unit Unit NNP cord-335975-m6lkrehi 1182 25 , , , cord-335975-m6lkrehi 1182 26 including include VBG cord-335975-m6lkrehi 1182 27 all all DT cord-335975-m6lkrehi 1182 28 mechanically mechanically RB cord-335975-m6lkrehi 1182 29 ventilated ventilate VBN cord-335975-m6lkrehi 1182 30 patients patient NNS cord-335975-m6lkrehi 1182 31 requiring require VBG cord-335975-m6lkrehi 1182 32 sedation sedation NN cord-335975-m6lkrehi 1182 33 who who WP cord-335975-m6lkrehi 1182 34 were be VBD cord-335975-m6lkrehi 1182 35 admitted admit VBN cord-335975-m6lkrehi 1182 36 for for IN cord-335975-m6lkrehi 1182 37 acute acute JJ cord-335975-m6lkrehi 1182 38 poisoning poisoning NN cord-335975-m6lkrehi 1182 39 . . . cord-335975-m6lkrehi 1183 1 They -PRON- PRP cord-335975-m6lkrehi 1183 2 were be VBD cord-335975-m6lkrehi 1183 3 randomly randomly RB cord-335975-m6lkrehi 1183 4 divided divide VBN cord-335975-m6lkrehi 1183 5 into into IN cord-335975-m6lkrehi 1183 6 two two CD cord-335975-m6lkrehi 1183 7 groups group NNS cord-335975-m6lkrehi 1183 8 G1 G1 NNP cord-335975-m6lkrehi 1183 9 et et NNP cord-335975-m6lkrehi 1183 10 G2 G2 NNP cord-335975-m6lkrehi 1183 11 receiving receive VBG cord-335975-m6lkrehi 1183 12 respectevily respectevily NNP cord-335975-m6lkrehi 1183 13 Propofol Propofol NNP cord-335975-m6lkrehi 1183 14 - - HYPH cord-335975-m6lkrehi 1183 15 Remifentanil Remifentanil NNP cord-335975-m6lkrehi 1183 16 and and CC cord-335975-m6lkrehi 1183 17 Midazolam Midazolam NNP cord-335975-m6lkrehi 1183 18 - - HYPH cord-335975-m6lkrehi 1183 19 Remifentanil Remifentanil NNP cord-335975-m6lkrehi 1183 20 . . . cord-335975-m6lkrehi 1184 1 Delirium delirium NN cord-335975-m6lkrehi 1184 2 assessment assessment NN cord-335975-m6lkrehi 1184 3 scores score NNS cord-335975-m6lkrehi 1184 4 were be VBD cord-335975-m6lkrehi 1184 5 judged judge VBN cord-335975-m6lkrehi 1184 6 not not RB cord-335975-m6lkrehi 1184 7 adapted adapt VBN cord-335975-m6lkrehi 1184 8 to to IN cord-335975-m6lkrehi 1184 9 our -PRON- PRP$ cord-335975-m6lkrehi 1184 10 population population NN cord-335975-m6lkrehi 1184 11 and and CC cord-335975-m6lkrehi 1184 12 we -PRON- PRP cord-335975-m6lkrehi 1184 13 retained retain VBD cord-335975-m6lkrehi 1184 14 the the DT cord-335975-m6lkrehi 1184 15 diagnosis diagnosis NN cord-335975-m6lkrehi 1184 16 of of IN cord-335975-m6lkrehi 1184 17 delirium delirium NN cord-335975-m6lkrehi 1184 18 on on IN cord-335975-m6lkrehi 1184 19 arguments argument NNS cord-335975-m6lkrehi 1184 20 inspired inspire VBN cord-335975-m6lkrehi 1184 21 from from IN cord-335975-m6lkrehi 1184 22 diagnostic diagnostic JJ cord-335975-m6lkrehi 1184 23 and and CC cord-335975-m6lkrehi 1184 24 statistical statistical JJ cord-335975-m6lkrehi 1184 25 manual manual NN cord-335975-m6lkrehi 1184 26 of of IN cord-335975-m6lkrehi 1184 27 mental mental JJ cord-335975-m6lkrehi 1184 28 disorders disorder NNS cord-335975-m6lkrehi 1184 29 fourth fourth NNP cord-335975-m6lkrehi 1184 30 edition edition NN cord-335975-m6lkrehi 1184 31 ( ( -LRB- cord-335975-m6lkrehi 1184 32 DSM DSM NNP cord-335975-m6lkrehi 1184 33 - - HYPH cord-335975-m6lkrehi 1184 34 IV IV NNP cord-335975-m6lkrehi 1184 35 ) ) -RRB- cord-335975-m6lkrehi 1184 36 . . . cord-335975-m6lkrehi 1185 1 Results result NNS cord-335975-m6lkrehi 1185 2 : : : cord-335975-m6lkrehi 1186 1 Until until IN cord-335975-m6lkrehi 1186 2 the the DT cord-335975-m6lkrehi 1186 3 15th 15th JJ cord-335975-m6lkrehi 1186 4 September September NNP cord-335975-m6lkrehi 1186 5 2017 2017 CD cord-335975-m6lkrehi 1186 6 , , , cord-335975-m6lkrehi 1186 7 35 35 CD cord-335975-m6lkrehi 1186 8 patients patient NNS cord-335975-m6lkrehi 1186 9 were be VBD cord-335975-m6lkrehi 1186 10 included include VBN cord-335975-m6lkrehi 1186 11 , , , cord-335975-m6lkrehi 1186 12 with with IN cord-335975-m6lkrehi 1186 13 22 22 CD cord-335975-m6lkrehi 1186 14 patients patient NNS cord-335975-m6lkrehi 1186 15 in in IN cord-335975-m6lkrehi 1186 16 G1 G1 NNP cord-335975-m6lkrehi 1186 17 and and CC cord-335975-m6lkrehi 1186 18 13 13 CD cord-335975-m6lkrehi 1186 19 in in IN cord-335975-m6lkrehi 1186 20 G2 G2 NNP cord-335975-m6lkrehi 1186 21 . . . cord-335975-m6lkrehi 1187 1 The the DT cord-335975-m6lkrehi 1187 2 two two CD cord-335975-m6lkrehi 1187 3 groups group NNS cord-335975-m6lkrehi 1187 4 were be VBD cord-335975-m6lkrehi 1187 5 comparable comparable JJ cord-335975-m6lkrehi 1187 6 in in IN cord-335975-m6lkrehi 1187 7 terms term NNS cord-335975-m6lkrehi 1187 8 of of IN cord-335975-m6lkrehi 1187 9 epidemiological epidemiological JJ cord-335975-m6lkrehi 1187 10 characteristics characteristic NNS cord-335975-m6lkrehi 1187 11 . . . cord-335975-m6lkrehi 1188 1 Delirium delirium NN cord-335975-m6lkrehi 1188 2 was be VBD cord-335975-m6lkrehi 1188 3 developed develop VBN cord-335975-m6lkrehi 1188 4 in in IN cord-335975-m6lkrehi 1188 5 9 9 CD cord-335975-m6lkrehi 1188 6 patients patient NNS cord-335975-m6lkrehi 1188 7 ( ( -LRB- cord-335975-m6lkrehi 1188 8 26 26 CD cord-335975-m6lkrehi 1188 9 % % NN cord-335975-m6lkrehi 1188 10 ) ) -RRB- cord-335975-m6lkrehi 1188 11 ( ( -LRB- cord-335975-m6lkrehi 1188 12 n n NN cord-335975-m6lkrehi 1188 13 = = SYM cord-335975-m6lkrehi 1188 14 5 5 CD cord-335975-m6lkrehi 1188 15 in in IN cord-335975-m6lkrehi 1188 16 G1 G1 NNP cord-335975-m6lkrehi 1188 17 and and CC cord-335975-m6lkrehi 1188 18 n n NN cord-335975-m6lkrehi 1188 19 = = SYM cord-335975-m6lkrehi 1188 20 4 4 CD cord-335975-m6lkrehi 1188 21 in in IN cord-335975-m6lkrehi 1188 22 G2 G2 NNP cord-335975-m6lkrehi 1188 23 ) ) -RRB- cord-335975-m6lkrehi 1188 24 with with IN cord-335975-m6lkrehi 1188 25 an an DT cord-335975-m6lkrehi 1188 26 average average JJ cord-335975-m6lkrehi 1188 27 duration duration NN cord-335975-m6lkrehi 1188 28 of of IN cord-335975-m6lkrehi 1188 29 18 18 CD cord-335975-m6lkrehi 1188 30 ± ± NNP cord-335975-m6lkrehi 1188 31 13 13 CD cord-335975-m6lkrehi 1188 32 h h NN cord-335975-m6lkrehi 1188 33 with with IN cord-335975-m6lkrehi 1188 34 no no DT cord-335975-m6lkrehi 1188 35 difference difference NN cord-335975-m6lkrehi 1188 36 between between IN cord-335975-m6lkrehi 1188 37 the the DT cord-335975-m6lkrehi 1188 38 2 2 CD cord-335975-m6lkrehi 1188 39 groups group NNS cord-335975-m6lkrehi 1188 40 ( ( -LRB- cord-335975-m6lkrehi 1188 41 13 13 CD cord-335975-m6lkrehi 1188 42 ± ± NNP cord-335975-m6lkrehi 1188 43 10 10 CD cord-335975-m6lkrehi 1188 44 h h NN cord-335975-m6lkrehi 1188 45 for for IN cord-335975-m6lkrehi 1188 46 G1 G1 NNP cord-335975-m6lkrehi 1188 47 - - HYPH cord-335975-m6lkrehi 1188 48 24 24 CD cord-335975-m6lkrehi 1188 49 ± ± NNP cord-335975-m6lkrehi 1188 50 16 16 CD cord-335975-m6lkrehi 1188 51 h h NN cord-335975-m6lkrehi 1188 52 for for IN cord-335975-m6lkrehi 1188 53 G2 G2 NNP cord-335975-m6lkrehi 1188 54 , , , cord-335975-m6lkrehi 1188 55 p p NN cord-335975-m6lkrehi 1188 56 = = SYM cord-335975-m6lkrehi 1188 57 0.268 0.268 CD cord-335975-m6lkrehi 1188 58 ) ) -RRB- cord-335975-m6lkrehi 1188 59 . . . cord-335975-m6lkrehi 1189 1 Compared compare VBN cord-335975-m6lkrehi 1189 2 to to IN cord-335975-m6lkrehi 1189 3 those those DT cord-335975-m6lkrehi 1189 4 without without IN cord-335975-m6lkrehi 1189 5 delirium delirium NN cord-335975-m6lkrehi 1189 6 , , , cord-335975-m6lkrehi 1189 7 no no DT cord-335975-m6lkrehi 1189 8 differences difference NNS cord-335975-m6lkrehi 1189 9 were be VBD cord-335975-m6lkrehi 1189 10 found find VBN cord-335975-m6lkrehi 1189 11 in in IN cord-335975-m6lkrehi 1189 12 the the DT cord-335975-m6lkrehi 1189 13 patient patient JJ cord-335975-m6lkrehi 1189 14 characteristics characteristic NNS cord-335975-m6lkrehi 1189 15 among among IN cord-335975-m6lkrehi 1189 16 these these DT cord-335975-m6lkrehi 1189 17 two two CD cord-335975-m6lkrehi 1189 18 groups group NNS cord-335975-m6lkrehi 1189 19 with with IN cord-335975-m6lkrehi 1189 20 regard regard NN cord-335975-m6lkrehi 1189 21 to to IN cord-335975-m6lkrehi 1189 22 sex sex NN cord-335975-m6lkrehi 1189 23 , , , cord-335975-m6lkrehi 1189 24 age age NN cord-335975-m6lkrehi 1189 25 , , , cord-335975-m6lkrehi 1189 26 psychiatric psychiatric JJ cord-335975-m6lkrehi 1189 27 history history NN cord-335975-m6lkrehi 1189 28 and and CC cord-335975-m6lkrehi 1189 29 severity severity NN cord-335975-m6lkrehi 1189 30 of of IN cord-335975-m6lkrehi 1189 31 illness illness NN cord-335975-m6lkrehi 1189 32 ( ( -LRB- cord-335975-m6lkrehi 1189 33 APACHE APACHE NNP cord-335975-m6lkrehi 1189 34 II II NNP cord-335975-m6lkrehi 1189 35 , , , cord-335975-m6lkrehi 1189 36 IGS IGS NNP cord-335975-m6lkrehi 1189 37 II II NNP cord-335975-m6lkrehi 1189 38 score score NN cord-335975-m6lkrehi 1189 39 ) ) -RRB- cord-335975-m6lkrehi 1189 40 and and CC cord-335975-m6lkrehi 1189 41 even even RB cord-335975-m6lkrehi 1189 42 with with IN cord-335975-m6lkrehi 1189 43 regard regard NN cord-335975-m6lkrehi 1189 44 to to IN cord-335975-m6lkrehi 1189 45 hypnotic hypnotic JJ cord-335975-m6lkrehi 1189 46 choice choice NN cord-335975-m6lkrehi 1189 47 ( ( -LRB- cord-335975-m6lkrehi 1189 48 5 5 CD cord-335975-m6lkrehi 1189 49 vs vs IN cord-335975-m6lkrehi 1189 50 4 4 CD cord-335975-m6lkrehi 1189 51 p p NN cord-335975-m6lkrehi 1189 52 = = SYM cord-335975-m6lkrehi 1189 53 0.599 0.599 CD cord-335975-m6lkrehi 1189 54 ) ) -RRB- cord-335975-m6lkrehi 1189 55 . . . cord-335975-m6lkrehi 1190 1 Delirium delirium NN cord-335975-m6lkrehi 1190 2 was be VBD cord-335975-m6lkrehi 1190 3 associated associate VBN cord-335975-m6lkrehi 1190 4 to to IN cord-335975-m6lkrehi 1190 5 prolonged prolong VBN cord-335975-m6lkrehi 1190 6 duration duration NN cord-335975-m6lkrehi 1190 7 of of IN cord-335975-m6lkrehi 1190 8 mechanical mechanical JJ cord-335975-m6lkrehi 1190 9 ventilation ventilation NN cord-335975-m6lkrehi 1190 10 ( ( -LRB- cord-335975-m6lkrehi 1190 11 69 69 CD cord-335975-m6lkrehi 1190 12 ± ± CD cord-335975-m6lkrehi 1190 13 73 73 CD cord-335975-m6lkrehi 1190 14 h h NN cord-335975-m6lkrehi 1190 15 vs vs IN cord-335975-m6lkrehi 1190 16 39 39 CD cord-335975-m6lkrehi 1190 17 ± ± NNP cord-335975-m6lkrehi 1190 18 69 69 CD cord-335975-m6lkrehi 1190 19 h h NN cord-335975-m6lkrehi 1190 20 , , , cord-335975-m6lkrehi 1190 21 p p NN cord-335975-m6lkrehi 1190 22 = = SYM cord-335975-m6lkrehi 1190 23 0.280 0.280 CD cord-335975-m6lkrehi 1190 24 ) ) -RRB- cord-335975-m6lkrehi 1190 25 and and CC cord-335975-m6lkrehi 1190 26 length length NN cord-335975-m6lkrehi 1190 27 of of IN cord-335975-m6lkrehi 1190 28 ICU ICU NNP cord-335975-m6lkrehi 1190 29 stay stay NN cord-335975-m6lkrehi 1190 30 ( ( -LRB- cord-335975-m6lkrehi 1190 31 91.51 91.51 CD cord-335975-m6lkrehi 1190 32 h h NN cord-335975-m6lkrehi 1190 33 vs vs IN cord-335975-m6lkrehi 1190 34 54.05 54.05 CD cord-335975-m6lkrehi 1190 35 h h NNP cord-335975-m6lkrehi 1190 36 , , , cord-335975-m6lkrehi 1190 37 p p NN cord-335975-m6lkrehi 1190 38 = = SYM cord-335975-m6lkrehi 1190 39 0.132 0.132 CD cord-335975-m6lkrehi 1190 40 ) ) -RRB- cord-335975-m6lkrehi 1190 41 without without IN cord-335975-m6lkrehi 1190 42 significant significant JJ cord-335975-m6lkrehi 1190 43 differences difference NNS cord-335975-m6lkrehi 1190 44 . . . cord-335975-m6lkrehi 1191 1 Delirious delirious JJ cord-335975-m6lkrehi 1191 2 patients patient NNS cord-335975-m6lkrehi 1191 3 had have VBD cord-335975-m6lkrehi 1191 4 more more JJR cord-335975-m6lkrehi 1191 5 hypotension hypotension NN cord-335975-m6lkrehi 1191 6 ( ( -LRB- cord-335975-m6lkrehi 1191 7 p p NN cord-335975-m6lkrehi 1191 8 = = SYM cord-335975-m6lkrehi 1191 9 0.008 0.008 CD cord-335975-m6lkrehi 1191 10 ) ) -RRB- cord-335975-m6lkrehi 1191 11 , , , cord-335975-m6lkrehi 1191 12 and and CC cord-335975-m6lkrehi 1191 13 received receive VBD cord-335975-m6lkrehi 1191 14 more more JJR cord-335975-m6lkrehi 1191 15 atropine atropine NN cord-335975-m6lkrehi 1191 16 ( ( -LRB- cord-335975-m6lkrehi 1191 17 0.026 0.026 CD cord-335975-m6lkrehi 1191 18 ) ) -RRB- cord-335975-m6lkrehi 1191 19 . . . cord-335975-m6lkrehi 1192 1 Multiple multiple JJ cord-335975-m6lkrehi 1192 2 logistic logistic JJ cord-335975-m6lkrehi 1192 3 regression regression NN cord-335975-m6lkrehi 1192 4 analysis analysis NN cord-335975-m6lkrehi 1192 5 identified identify VBD cord-335975-m6lkrehi 1192 6 atropine atropine NN cord-335975-m6lkrehi 1192 7 ( ( -LRB- cord-335975-m6lkrehi 1192 8 OR or CC cord-335975-m6lkrehi 1192 9 2.333 2.333 CD cord-335975-m6lkrehi 1192 10 , , . cord-335975-m6lkrehi 1193 1 5%Cl 5%cl LS cord-335975-m6lkrehi 1193 2 0.992 0.992 CD cord-335975-m6lkrehi 1193 3 - - HYPH cord-335975-m6lkrehi 1193 4 5.489 5.489 CD cord-335975-m6lkrehi 1193 5 , , , cord-335975-m6lkrehi 1193 6 p p NN cord-335975-m6lkrehi 1193 7 = = SYM cord-335975-m6lkrehi 1193 8 0.026 0.026 CD cord-335975-m6lkrehi 1193 9 ) ) -RRB- cord-335975-m6lkrehi 1194 1 as as IN cord-335975-m6lkrehi 1194 2 an an DT cord-335975-m6lkrehi 1194 3 independent independent JJ cord-335975-m6lkrehi 1194 4 risk risk NN cord-335975-m6lkrehi 1194 5 factor factor NN cord-335975-m6lkrehi 1194 6 for for IN cord-335975-m6lkrehi 1194 7 delirium delirium NN cord-335975-m6lkrehi 1194 8 . . . cord-335975-m6lkrehi 1195 1 The the DT cord-335975-m6lkrehi 1195 2 diagnosis diagnosis NN cord-335975-m6lkrehi 1195 3 and and CC cord-335975-m6lkrehi 1195 4 prevention prevention NN cord-335975-m6lkrehi 1195 5 of of IN cord-335975-m6lkrehi 1195 6 ICU ICU NNP cord-335975-m6lkrehi 1195 7 delirium delirium NN cord-335975-m6lkrehi 1195 8 are be VBP cord-335975-m6lkrehi 1195 9 subjects subject NNS cord-335975-m6lkrehi 1195 10 of of IN cord-335975-m6lkrehi 1195 11 multiple multiple JJ cord-335975-m6lkrehi 1195 12 ongoing ongoing JJ cord-335975-m6lkrehi 1195 13 investigations investigation NNS cord-335975-m6lkrehi 1195 14 . . . cord-335975-m6lkrehi 1196 1 We -PRON- PRP cord-335975-m6lkrehi 1196 2 carried carry VBD cord-335975-m6lkrehi 1196 3 out out RP cord-335975-m6lkrehi 1196 4 this this DT cord-335975-m6lkrehi 1196 5 study study NN cord-335975-m6lkrehi 1196 6 to to TO cord-335975-m6lkrehi 1196 7 detect detect VB cord-335975-m6lkrehi 1196 8 the the DT cord-335975-m6lkrehi 1196 9 risk risk NN cord-335975-m6lkrehi 1196 10 factors factor NNS cord-335975-m6lkrehi 1196 11 of of IN cord-335975-m6lkrehi 1196 12 delirium delirium NN cord-335975-m6lkrehi 1196 13 in in IN cord-335975-m6lkrehi 1196 14 order order NN cord-335975-m6lkrehi 1196 15 to to TO cord-335975-m6lkrehi 1196 16 prevent prevent VB cord-335975-m6lkrehi 1196 17 it -PRON- PRP cord-335975-m6lkrehi 1196 18 . . . cord-335975-m6lkrehi 1197 1 It -PRON- PRP cord-335975-m6lkrehi 1197 2 is be VBZ cord-335975-m6lkrehi 1197 3 important important JJ cord-335975-m6lkrehi 1197 4 to to TO cord-335975-m6lkrehi 1197 5 note note VB cord-335975-m6lkrehi 1197 6 that that IN cord-335975-m6lkrehi 1197 7 our -PRON- PRP$ cord-335975-m6lkrehi 1197 8 results result NNS cord-335975-m6lkrehi 1197 9 are be VBP cord-335975-m6lkrehi 1197 10 influenced influence VBN cord-335975-m6lkrehi 1197 11 by by IN cord-335975-m6lkrehi 1197 12 the the DT cord-335975-m6lkrehi 1197 13 studied study VBN cord-335975-m6lkrehi 1197 14 population population NN cord-335975-m6lkrehi 1197 15 and and CC cord-335975-m6lkrehi 1197 16 are be VBP cord-335975-m6lkrehi 1197 17 only only RB cord-335975-m6lkrehi 1197 18 preliminary preliminary JJ cord-335975-m6lkrehi 1197 19 . . . cord-335975-m6lkrehi 1198 1 We -PRON- PRP cord-335975-m6lkrehi 1198 2 rely rely VBP cord-335975-m6lkrehi 1198 3 on on IN cord-335975-m6lkrehi 1198 4 the the DT cord-335975-m6lkrehi 1198 5 study study NN cord-335975-m6lkrehi 1198 6 pursuit pursuit NN cord-335975-m6lkrehi 1198 7 and and CC cord-335975-m6lkrehi 1198 8 the the DT cord-335975-m6lkrehi 1198 9 sample sample NN cord-335975-m6lkrehi 1198 10 enlargement enlargement NN cord-335975-m6lkrehi 1198 11 to to TO cord-335975-m6lkrehi 1198 12 better better RB cord-335975-m6lkrehi 1198 13 inform inform VB cord-335975-m6lkrehi 1198 14 us -PRON- PRP cord-335975-m6lkrehi 1198 15 as as RB cord-335975-m6lkrehi 1198 16 well well RB cord-335975-m6lkrehi 1198 17 on on IN cord-335975-m6lkrehi 1198 18 risk risk NN cord-335975-m6lkrehi 1198 19 factors factor NNS cord-335975-m6lkrehi 1198 20 as as IN cord-335975-m6lkrehi 1198 21 protective protective JJ cord-335975-m6lkrehi 1198 22 . . . cord-335975-m6lkrehi 1199 1 Introduction introduction NN cord-335975-m6lkrehi 1199 2 : : : cord-335975-m6lkrehi 1200 1 Background background NN cord-335975-m6lkrehi 1200 2 : : : cord-335975-m6lkrehi 1201 1 Severe severe JJ cord-335975-m6lkrehi 1201 2 alcohol alcohol NN cord-335975-m6lkrehi 1201 3 withdrawal withdrawal NN cord-335975-m6lkrehi 1201 4 syndrome syndrome NN cord-335975-m6lkrehi 1201 5 is be VBZ cord-335975-m6lkrehi 1201 6 a a DT cord-335975-m6lkrehi 1201 7 common common JJ cord-335975-m6lkrehi 1201 8 cause cause NN cord-335975-m6lkrehi 1201 9 of of IN cord-335975-m6lkrehi 1201 10 hospital hospital NN cord-335975-m6lkrehi 1201 11 admission admission NN cord-335975-m6lkrehi 1201 12 . . . cord-335975-m6lkrehi 1202 1 Delirium delirium NN cord-335975-m6lkrehi 1202 2 tremens tremens NN cord-335975-m6lkrehi 1202 3 is be VBZ cord-335975-m6lkrehi 1202 4 a a DT cord-335975-m6lkrehi 1202 5 potentially potentially RB cord-335975-m6lkrehi 1202 6 fatal fatal JJ cord-335975-m6lkrehi 1202 7 complication complication NN cord-335975-m6lkrehi 1202 8 of of IN cord-335975-m6lkrehi 1202 9 alcohol alcohol NN cord-335975-m6lkrehi 1202 10 withdrawal withdrawal NN cord-335975-m6lkrehi 1202 11 . . . cord-335975-m6lkrehi 1203 1 In in IN cord-335975-m6lkrehi 1203 2 severe severe JJ cord-335975-m6lkrehi 1203 3 delirium delirium NN cord-335975-m6lkrehi 1203 4 , , , cord-335975-m6lkrehi 1203 5 very very RB cord-335975-m6lkrehi 1203 6 large large JJ cord-335975-m6lkrehi 1203 7 dosages dosage NNS cord-335975-m6lkrehi 1203 8 of of IN cord-335975-m6lkrehi 1203 9 benzodiazepines benzodiazepine NNS cord-335975-m6lkrehi 1203 10 can can MD cord-335975-m6lkrehi 1203 11 be be VB cord-335975-m6lkrehi 1203 12 required require VBN cord-335975-m6lkrehi 1203 13 despite despite IN cord-335975-m6lkrehi 1203 14 well well RB cord-335975-m6lkrehi 1203 15 described describe VBN cord-335975-m6lkrehi 1203 16 side side NN cord-335975-m6lkrehi 1203 17 effects effect NNS cord-335975-m6lkrehi 1203 18 , , , cord-335975-m6lkrehi 1203 19 such such JJ cord-335975-m6lkrehi 1203 20 as as IN cord-335975-m6lkrehi 1203 21 coma coma NN cord-335975-m6lkrehi 1203 22 and and CC cord-335975-m6lkrehi 1203 23 hypoxic hypoxic JJ cord-335975-m6lkrehi 1203 24 cardiac cardiac JJ cord-335975-m6lkrehi 1203 25 arrest arrest NN cord-335975-m6lkrehi 1203 26 , , , cord-335975-m6lkrehi 1203 27 although although IN cord-335975-m6lkrehi 1203 28 there there EX cord-335975-m6lkrehi 1203 29 is be VBZ cord-335975-m6lkrehi 1203 30 no no DT cord-335975-m6lkrehi 1203 31 recommendations recommendation NNS cord-335975-m6lkrehi 1203 32 for for IN cord-335975-m6lkrehi 1203 33 standardized standardized JJ cord-335975-m6lkrehi 1203 34 treatments treatment NNS cord-335975-m6lkrehi 1203 35 . . . cord-335975-m6lkrehi 1204 1 Objective objective JJ cord-335975-m6lkrehi 1204 2 -The -the DT cord-335975-m6lkrehi 1204 3 aim aim NN cord-335975-m6lkrehi 1204 4 of of IN cord-335975-m6lkrehi 1204 5 this this DT cord-335975-m6lkrehi 1204 6 study study NN cord-335975-m6lkrehi 1204 7 was be VBD cord-335975-m6lkrehi 1204 8 to to TO cord-335975-m6lkrehi 1204 9 describe describe VB cord-335975-m6lkrehi 1204 10 outcomes outcome NNS cord-335975-m6lkrehi 1204 11 and and CC cord-335975-m6lkrehi 1204 12 risk risk NN cord-335975-m6lkrehi 1204 13 factors factor NNS cord-335975-m6lkrehi 1204 14 for for IN cord-335975-m6lkrehi 1204 15 complications complication NNS cord-335975-m6lkrehi 1204 16 in in IN cord-335975-m6lkrehi 1204 17 patients patient NNS cord-335975-m6lkrehi 1204 18 with with IN cord-335975-m6lkrehi 1204 19 severe severe JJ cord-335975-m6lkrehi 1204 20 alcohol alcohol NN cord-335975-m6lkrehi 1204 21 withdrawal withdrawal NN cord-335975-m6lkrehi 1204 22 syndrome syndrome NN cord-335975-m6lkrehi 1204 23 treated treat VBN cord-335975-m6lkrehi 1204 24 in in IN cord-335975-m6lkrehi 1204 25 intensive intensive JJ cord-335975-m6lkrehi 1204 26 care care NN cord-335975-m6lkrehi 1204 27 unit unit NN cord-335975-m6lkrehi 1204 28 with with IN cord-335975-m6lkrehi 1204 29 continous continous JJ cord-335975-m6lkrehi 1204 30 infusion infusion NN cord-335975-m6lkrehi 1204 31 of of IN cord-335975-m6lkrehi 1204 32 benzodiazepine benzodiazepine NN cord-335975-m6lkrehi 1204 33 ( ( -LRB- cord-335975-m6lkrehi 1204 34 BZD BZD NNP cord-335975-m6lkrehi 1204 35 ) ) -RRB- cord-335975-m6lkrehi 1204 36 . . . cord-335975-m6lkrehi 1205 1 We -PRON- PRP cord-335975-m6lkrehi 1205 2 retrospectively retrospectively RB cord-335975-m6lkrehi 1205 3 reviewed review VBD cord-335975-m6lkrehi 1205 4 the the DT cord-335975-m6lkrehi 1205 5 medical medical JJ cord-335975-m6lkrehi 1205 6 records record NNS cord-335975-m6lkrehi 1205 7 of of IN cord-335975-m6lkrehi 1205 8 all all DT cord-335975-m6lkrehi 1205 9 patients patient NNS cord-335975-m6lkrehi 1205 10 hospitalized hospitalize VBN cord-335975-m6lkrehi 1205 11 for for IN cord-335975-m6lkrehi 1205 12 alcohol alcohol NN cord-335975-m6lkrehi 1205 13 withdrawal withdrawal NN cord-335975-m6lkrehi 1205 14 syndrome syndrome NN cord-335975-m6lkrehi 1205 15 between between IN cord-335975-m6lkrehi 1205 16 2006 2006 CD cord-335975-m6lkrehi 1205 17 and and CC cord-335975-m6lkrehi 1205 18 2016 2016 CD cord-335975-m6lkrehi 1205 19 . . . cord-335975-m6lkrehi 1206 1 Only only RB cord-335975-m6lkrehi 1206 2 those those DT cord-335975-m6lkrehi 1206 3 who who WP cord-335975-m6lkrehi 1206 4 received receive VBD cord-335975-m6lkrehi 1206 5 continous continous JJ cord-335975-m6lkrehi 1206 6 - - HYPH cord-335975-m6lkrehi 1206 7 infusion infusion NN cord-335975-m6lkrehi 1206 8 of of IN cord-335975-m6lkrehi 1206 9 BZD BZD NNP cord-335975-m6lkrehi 1206 10 , , , cord-335975-m6lkrehi 1206 11 associated associate VBN cord-335975-m6lkrehi 1206 12 with with IN cord-335975-m6lkrehi 1206 13 close close JJ cord-335975-m6lkrehi 1206 14 clinical clinical JJ cord-335975-m6lkrehi 1206 15 monitoring monitoring NN cord-335975-m6lkrehi 1206 16 and and CC cord-335975-m6lkrehi 1206 17 the the DT cord-335975-m6lkrehi 1206 18 evaluation evaluation NN cord-335975-m6lkrehi 1206 19 of of IN cord-335975-m6lkrehi 1206 20 RASS RASS NNP cord-335975-m6lkrehi 1206 21 and and CC cord-335975-m6lkrehi 1206 22 Cushman Cushman NNP cord-335975-m6lkrehi 1206 23 scores score NNS cord-335975-m6lkrehi 1206 24 , , , cord-335975-m6lkrehi 1206 25 without without IN cord-335975-m6lkrehi 1206 26 systematic systematic JJ cord-335975-m6lkrehi 1206 27 recourse recourse NN cord-335975-m6lkrehi 1206 28 to to IN cord-335975-m6lkrehi 1206 29 mechanical mechanical JJ cord-335975-m6lkrehi 1206 30 ventilation ventilation NN cord-335975-m6lkrehi 1206 31 , , , cord-335975-m6lkrehi 1206 32 were be VBD cord-335975-m6lkrehi 1206 33 included include VBN cord-335975-m6lkrehi 1206 34 . . . cord-335975-m6lkrehi 1207 1 Results result NNS cord-335975-m6lkrehi 1207 2 : : : cord-335975-m6lkrehi 1208 1 We -PRON- PRP cord-335975-m6lkrehi 1208 2 studied study VBD cord-335975-m6lkrehi 1208 3 104 104 CD cord-335975-m6lkrehi 1208 4 patients patient NNS cord-335975-m6lkrehi 1208 5 hospitalized hospitalize VBN cord-335975-m6lkrehi 1208 6 in in IN cord-335975-m6lkrehi 1208 7 ICU ICU NNP cord-335975-m6lkrehi 1208 8 for for IN cord-335975-m6lkrehi 1208 9 severe severe JJ cord-335975-m6lkrehi 1208 10 alcohol alcohol NN cord-335975-m6lkrehi 1208 11 withdrawal withdrawal NN cord-335975-m6lkrehi 1208 12 syndrome syndrome NN cord-335975-m6lkrehi 1208 13 . . . cord-335975-m6lkrehi 1209 1 The the DT cord-335975-m6lkrehi 1209 2 mean mean JJ cord-335975-m6lkrehi 1209 3 age age NN cord-335975-m6lkrehi 1209 4 ( ( -LRB- cord-335975-m6lkrehi 1209 5 SD SD NNP cord-335975-m6lkrehi 1209 6 ) ) -RRB- cord-335975-m6lkrehi 1209 7 was be VBD cord-335975-m6lkrehi 1209 8 48.7 48.7 CD cord-335975-m6lkrehi 1209 9 ± ± CD cord-335975-m6lkrehi 1209 10 8.7 8.7 CD cord-335975-m6lkrehi 1209 11 years year NNS cord-335975-m6lkrehi 1209 12 , , , cord-335975-m6lkrehi 1209 13 mean mean VB cord-335975-m6lkrehi 1209 14 ICU ICU NNP cord-335975-m6lkrehi 1209 15 admission admission NN cord-335975-m6lkrehi 1209 16 SAPS SAPS NNP cord-335975-m6lkrehi 1209 17 ( ( -LRB- cord-335975-m6lkrehi 1209 18 simplified simplify VBN cord-335975-m6lkrehi 1209 19 acute acute JJ cord-335975-m6lkrehi 1209 20 physiology physiology NN cord-335975-m6lkrehi 1209 21 score score NN cord-335975-m6lkrehi 1209 22 ) ) -RRB- cord-335975-m6lkrehi 1210 1 II II NNP cord-335975-m6lkrehi 1210 2 score score NN cord-335975-m6lkrehi 1210 3 was be VBD cord-335975-m6lkrehi 1210 4 20 20 CD cord-335975-m6lkrehi 1210 5 ± ± CD cord-335975-m6lkrehi 1210 6 6.1 6.1 CD cord-335975-m6lkrehi 1210 7 . . . cord-335975-m6lkrehi 1211 1 All all DT cord-335975-m6lkrehi 1211 2 of of IN cord-335975-m6lkrehi 1211 3 them -PRON- PRP cord-335975-m6lkrehi 1211 4 have have VBP cord-335975-m6lkrehi 1211 5 received receive VBN cord-335975-m6lkrehi 1211 6 continous continous JJ cord-335975-m6lkrehi 1211 7 infusion infusion NN cord-335975-m6lkrehi 1211 8 of of IN cord-335975-m6lkrehi 1211 9 midazolam midazolam NN cord-335975-m6lkrehi 1211 10 , , , cord-335975-m6lkrehi 1211 11 with with IN cord-335975-m6lkrehi 1211 12 a a DT cord-335975-m6lkrehi 1211 13 median median JJ cord-335975-m6lkrehi 1211 14 maximum maximum JJ cord-335975-m6lkrehi 1211 15 perfusion perfusion NN cord-335975-m6lkrehi 1211 16 velocity velocity NN cord-335975-m6lkrehi 1211 17 of of IN cord-335975-m6lkrehi 1211 18 8 8 CD cord-335975-m6lkrehi 1211 19 mg mg NNP cord-335975-m6lkrehi 1211 20 h h NN cord-335975-m6lkrehi 1211 21 ( ( -LRB- cord-335975-m6lkrehi 1211 22 interquartile interquartile JJ cord-335975-m6lkrehi 1211 23 range range NN cord-335975-m6lkrehi 1211 24 , , , cord-335975-m6lkrehi 1211 25 ( ( -LRB- cord-335975-m6lkrehi 1211 26 5 5 CD cord-335975-m6lkrehi 1211 27 , , , cord-335975-m6lkrehi 1211 28 12 12 CD cord-335975-m6lkrehi 1211 29 ) ) -RRB- cord-335975-m6lkrehi 1211 30 ) ) -RRB- cord-335975-m6lkrehi 1211 31 . . . cord-335975-m6lkrehi 1212 1 The the DT cord-335975-m6lkrehi 1212 2 median median JJ cord-335975-m6lkrehi 1212 3 duration duration NN cord-335975-m6lkrehi 1212 4 of of IN cord-335975-m6lkrehi 1212 5 treatement treatement NN cord-335975-m6lkrehi 1212 6 was be VBD cord-335975-m6lkrehi 1212 7 2 2 CD cord-335975-m6lkrehi 1212 8 days day NNS cord-335975-m6lkrehi 1212 9 ( ( -LRB- cord-335975-m6lkrehi 1212 10 interquartile interquartile JJ cord-335975-m6lkrehi 1212 11 range range NN cord-335975-m6lkrehi 1212 12 , , , cord-335975-m6lkrehi 1212 13 ( ( -LRB- cord-335975-m6lkrehi 1212 14 1 1 CD cord-335975-m6lkrehi 1212 15 , , , cord-335975-m6lkrehi 1212 16 3 3 CD cord-335975-m6lkrehi 1212 17 ) ) -RRB- cord-335975-m6lkrehi 1212 18 ) ) -RRB- cord-335975-m6lkrehi 1212 19 . . . cord-335975-m6lkrehi 1213 1 Thirteen thirteen CD cord-335975-m6lkrehi 1213 2 patients patient NNS cord-335975-m6lkrehi 1213 3 ( ( -LRB- cord-335975-m6lkrehi 1213 4 12 12 CD cord-335975-m6lkrehi 1213 5 % % NN cord-335975-m6lkrehi 1213 6 ) ) -RRB- cord-335975-m6lkrehi 1213 7 developed develop VBN cord-335975-m6lkrehi 1213 8 pneumonia pneumonia NN cord-335975-m6lkrehi 1213 9 , , , cord-335975-m6lkrehi 1213 10 and and CC cord-335975-m6lkrehi 1213 11 or or CC cord-335975-m6lkrehi 1213 12 required require VBN cord-335975-m6lkrehi 1213 13 intubation intubation NN cord-335975-m6lkrehi 1213 14 , , , cord-335975-m6lkrehi 1213 15 and and CC cord-335975-m6lkrehi 1213 16 8 8 CD cord-335975-m6lkrehi 1213 17 ( ( -LRB- cord-335975-m6lkrehi 1213 18 8 8 CD cord-335975-m6lkrehi 1213 19 % % NN cord-335975-m6lkrehi 1213 20 ) ) -RRB- cord-335975-m6lkrehi 1213 21 have have VBP cord-335975-m6lkrehi 1213 22 had have VBN cord-335975-m6lkrehi 1213 23 seizures seizure NNS cord-335975-m6lkrehi 1213 24 . . . cord-335975-m6lkrehi 1214 1 No no DT cord-335975-m6lkrehi 1214 2 cardiac cardiac JJ cord-335975-m6lkrehi 1214 3 arrest arrest NN cord-335975-m6lkrehi 1214 4 and and CC cord-335975-m6lkrehi 1214 5 death death NN cord-335975-m6lkrehi 1214 6 was be VBD cord-335975-m6lkrehi 1214 7 observed observe VBN cord-335975-m6lkrehi 1214 8 . . . cord-335975-m6lkrehi 1215 1 ICU ICU NNP cord-335975-m6lkrehi 1215 2 length length NN cord-335975-m6lkrehi 1215 3 of of IN cord-335975-m6lkrehi 1215 4 stay stay NN cord-335975-m6lkrehi 1215 5 ( ( -LRB- cord-335975-m6lkrehi 1215 6 LOS LOS NNP cord-335975-m6lkrehi 1215 7 ) ) -RRB- cord-335975-m6lkrehi 1215 8 was be VBD cord-335975-m6lkrehi 1215 9 3 3 CD cord-335975-m6lkrehi 1215 10 days day NNS cord-335975-m6lkrehi 1215 11 ( ( -LRB- cord-335975-m6lkrehi 1215 12 2 2 CD cord-335975-m6lkrehi 1215 13 , , , cord-335975-m6lkrehi 1215 14 5 5 CD cord-335975-m6lkrehi 1215 15 ) ) -RRB- cord-335975-m6lkrehi 1215 16 ( ( -LRB- cord-335975-m6lkrehi 1215 17 median median NN cord-335975-m6lkrehi 1215 18 , , , cord-335975-m6lkrehi 1215 19 interquartile interquartile JJ cord-335975-m6lkrehi 1215 20 range range NN cord-335975-m6lkrehi 1215 21 ) ) -RRB- cord-335975-m6lkrehi 1215 22 . . . cord-335975-m6lkrehi 1216 1 Patients patient NNS cord-335975-m6lkrehi 1216 2 who who WP cord-335975-m6lkrehi 1216 3 requiried requirie VBD cord-335975-m6lkrehi 1216 4 intubation intubation NN cord-335975-m6lkrehi 1216 5 and and CC cord-335975-m6lkrehi 1216 6 or or CC cord-335975-m6lkrehi 1216 7 developed develop VBD cord-335975-m6lkrehi 1216 8 pneumonia pneumonia NN cord-335975-m6lkrehi 1216 9 , , , cord-335975-m6lkrehi 1216 10 received receive VBD cord-335975-m6lkrehi 1216 11 substantially substantially RB cord-335975-m6lkrehi 1216 12 more more JJR cord-335975-m6lkrehi 1216 13 BZD BZD NNP cord-335975-m6lkrehi 1216 14 ( ( -LRB- cord-335975-m6lkrehi 1216 15 median median JJ cord-335975-m6lkrehi 1216 16 total total JJ cord-335975-m6lkrehi 1216 17 dose dose NN cord-335975-m6lkrehi 1216 18 , , , cord-335975-m6lkrehi 1216 19 428 428 CD cord-335975-m6lkrehi 1216 20 mg mg NN cord-335975-m6lkrehi 1216 21 of of IN cord-335975-m6lkrehi 1216 22 midazolam midazolam NNP cord-335975-m6lkrehi 1216 23 vs. vs. CC cord-335975-m6lkrehi 1216 24 147 147 CD cord-335975-m6lkrehi 1216 25 mg mg NNS cord-335975-m6lkrehi 1216 26 in in IN cord-335975-m6lkrehi 1216 27 the the DT cord-335975-m6lkrehi 1216 28 non non JJ cord-335975-m6lkrehi 1216 29 - - JJ cord-335975-m6lkrehi 1216 30 complicated complicated JJ cord-335975-m6lkrehi 1216 31 group group NN cord-335975-m6lkrehi 1216 32 + + CC cord-335975-m6lkrehi 1216 33 p p NN cord-335975-m6lkrehi 1216 34 < < XX cord-335975-m6lkrehi 1216 35 0.001 0.001 CD cord-335975-m6lkrehi 1216 36 ) ) -RRB- cord-335975-m6lkrehi 1216 37 , , , cord-335975-m6lkrehi 1216 38 and and CC cord-335975-m6lkrehi 1216 39 their -PRON- PRP$ cord-335975-m6lkrehi 1216 40 ICU ICU NNP cord-335975-m6lkrehi 1216 41 LOS LOS NNP cord-335975-m6lkrehi 1216 42 was be VBD cord-335975-m6lkrehi 1216 43 higher high JJR cord-335975-m6lkrehi 1216 44 ( ( -LRB- cord-335975-m6lkrehi 1216 45 median median NN cord-335975-m6lkrehi 1216 46 , , , cord-335975-m6lkrehi 1216 47 5 5 CD cord-335975-m6lkrehi 1216 48 days day NNS cord-335975-m6lkrehi 1216 49 vs. vs. CC cord-335975-m6lkrehi 1216 50 3 3 CD cord-335975-m6lkrehi 1216 51 days day NNS cord-335975-m6lkrehi 1216 52 + + CC cord-335975-m6lkrehi 1216 53 p p NN cord-335975-m6lkrehi 1216 54 < < XX cord-335975-m6lkrehi 1216 55 0.001 0.001 CD cord-335975-m6lkrehi 1216 56 ) ) -RRB- cord-335975-m6lkrehi 1216 57 . . . cord-335975-m6lkrehi 1217 1 Endotracheal endotracheal JJ cord-335975-m6lkrehi 1217 2 intubation intubation NN cord-335975-m6lkrehi 1217 3 and and CC cord-335975-m6lkrehi 1217 4 or or CC cord-335975-m6lkrehi 1217 5 development development NN cord-335975-m6lkrehi 1217 6 of of IN cord-335975-m6lkrehi 1217 7 pneumonia pneumonia NN cord-335975-m6lkrehi 1217 8 were be VBD cord-335975-m6lkrehi 1217 9 associated associate VBN cord-335975-m6lkrehi 1217 10 with with IN cord-335975-m6lkrehi 1217 11 a a DT cord-335975-m6lkrehi 1217 12 higher high JJR cord-335975-m6lkrehi 1217 13 maximum maximum JJ cord-335975-m6lkrehi 1217 14 perfusion perfusion NN cord-335975-m6lkrehi 1217 15 velocity velocity NN cord-335975-m6lkrehi 1217 16 of of IN cord-335975-m6lkrehi 1217 17 midazolam midazolam NN cord-335975-m6lkrehi 1217 18 ( ( -LRB- cord-335975-m6lkrehi 1217 19 > > NFP cord-335975-m6lkrehi 1217 20 8 8 CD cord-335975-m6lkrehi 1217 21 mg mg NNP cord-335975-m6lkrehi 1217 22 h h NN cord-335975-m6lkrehi 1217 23 ) ) -RRB- cord-335975-m6lkrehi 1217 24 ( ( -LRB- cord-335975-m6lkrehi 1217 25 OR OR NNP cord-335975-m6lkrehi 1217 26 18.83 18.83 CD cord-335975-m6lkrehi 1217 27 , , , cord-335975-m6lkrehi 1217 28 IC IC NNP cord-335975-m6lkrehi 1217 29 95 95 CD cord-335975-m6lkrehi 1217 30 % % NN cord-335975-m6lkrehi 1217 31 ( ( -LRB- cord-335975-m6lkrehi 1217 32 2.11 2.11 CD cord-335975-m6lkrehi 1217 33 - - SYM cord-335975-m6lkrehi 1217 34 168.15 168.15 CD cord-335975-m6lkrehi 1217 35 ) ) -RRB- cord-335975-m6lkrehi 1217 36 , , , cord-335975-m6lkrehi 1217 37 p p NN cord-335975-m6lkrehi 1217 38 = = SYM cord-335975-m6lkrehi 1217 39 0.009 0.009 CD cord-335975-m6lkrehi 1217 40 ) ) -RRB- cord-335975-m6lkrehi 1217 41 . . . cord-335975-m6lkrehi 1218 1 Previous previous JJ cord-335975-m6lkrehi 1218 2 episodes episode NNS cord-335975-m6lkrehi 1218 3 of of IN cord-335975-m6lkrehi 1218 4 delirium delirium NN cord-335975-m6lkrehi 1218 5 tremens tremen NNS cord-335975-m6lkrehi 1218 6 before before IN cord-335975-m6lkrehi 1218 7 ICU ICU NNP cord-335975-m6lkrehi 1218 8 admission admission NN cord-335975-m6lkrehi 1218 9 were be VBD cord-335975-m6lkrehi 1218 10 associated associate VBN cord-335975-m6lkrehi 1218 11 with with IN cord-335975-m6lkrehi 1218 12 higher high JJR cord-335975-m6lkrehi 1218 13 complications complication NNS cord-335975-m6lkrehi 1218 14 such such JJ cord-335975-m6lkrehi 1218 15 as as IN cord-335975-m6lkrehi 1218 16 mechanical mechanical JJ cord-335975-m6lkrehi 1218 17 ventilation ventilation NN cord-335975-m6lkrehi 1218 18 and and CC cord-335975-m6lkrehi 1218 19 or or CC cord-335975-m6lkrehi 1218 20 pneumonia pneumonia NN cord-335975-m6lkrehi 1218 21 ( ( -LRB- cord-335975-m6lkrehi 1218 22 OR or CC cord-335975-m6lkrehi 1218 23 11.29 11.29 CD cord-335975-m6lkrehi 1218 24 , , , cord-335975-m6lkrehi 1218 25 IC IC NNP cord-335975-m6lkrehi 1218 26 95 95 CD cord-335975-m6lkrehi 1218 27 % % NN cord-335975-m6lkrehi 1218 28 ( ( -LRB- cord-335975-m6lkrehi 1218 29 1.45 1.45 CD cord-335975-m6lkrehi 1218 30 - - SYM cord-335975-m6lkrehi 1218 31 87.60 87.60 CD cord-335975-m6lkrehi 1218 32 ) ) -RRB- cord-335975-m6lkrehi 1218 33 , , , cord-335975-m6lkrehi 1218 34 p p NN cord-335975-m6lkrehi 1218 35 = = SYM cord-335975-m6lkrehi 1218 36 0.02 0.02 CD cord-335975-m6lkrehi 1218 37 ) ) -RRB- cord-335975-m6lkrehi 1218 38 . . . cord-335975-m6lkrehi 1219 1 In in IN cord-335975-m6lkrehi 1219 2 severe severe JJ cord-335975-m6lkrehi 1219 3 delirium delirium NN cord-335975-m6lkrehi 1219 4 , , , cord-335975-m6lkrehi 1219 5 very very RB cord-335975-m6lkrehi 1219 6 large large JJ cord-335975-m6lkrehi 1219 7 dosages dosage NNS cord-335975-m6lkrehi 1219 8 of of IN cord-335975-m6lkrehi 1219 9 benzodiazepines benzodiazepine NNS cord-335975-m6lkrehi 1219 10 can can MD cord-335975-m6lkrehi 1219 11 be be VB cord-335975-m6lkrehi 1219 12 used use VBN cord-335975-m6lkrehi 1219 13 without without IN cord-335975-m6lkrehi 1219 14 systematic systematic JJ cord-335975-m6lkrehi 1219 15 mechanical mechanical JJ cord-335975-m6lkrehi 1219 16 ventilation ventilation NN cord-335975-m6lkrehi 1219 17 with with IN cord-335975-m6lkrehi 1219 18 a a DT cord-335975-m6lkrehi 1219 19 low low JJ cord-335975-m6lkrehi 1219 20 incidence incidence NN cord-335975-m6lkrehi 1219 21 of of IN cord-335975-m6lkrehi 1219 22 complications complication NNS cord-335975-m6lkrehi 1219 23 . . . cord-335975-m6lkrehi 1220 1 Introduction introduction NN cord-335975-m6lkrehi 1220 2 : : : cord-335975-m6lkrehi 1221 1 Delirium delirium NN cord-335975-m6lkrehi 1221 2 is be VBZ cord-335975-m6lkrehi 1221 3 frequent frequent JJ cord-335975-m6lkrehi 1221 4 in in IN cord-335975-m6lkrehi 1221 5 intensive intensive JJ cord-335975-m6lkrehi 1221 6 care care NN cord-335975-m6lkrehi 1221 7 unit unit NN cord-335975-m6lkrehi 1221 8 ( ( -LRB- cord-335975-m6lkrehi 1221 9 ICU ICU NNP cord-335975-m6lkrehi 1221 10 ) ) -RRB- cord-335975-m6lkrehi 1221 11 patients patient NNS cord-335975-m6lkrehi 1221 12 and and CC cord-335975-m6lkrehi 1221 13 is be VBZ cord-335975-m6lkrehi 1221 14 associated associate VBN cord-335975-m6lkrehi 1221 15 with with IN cord-335975-m6lkrehi 1221 16 increased increase VBN cord-335975-m6lkrehi 1221 17 mortality mortality NN cord-335975-m6lkrehi 1221 18 , , , cord-335975-m6lkrehi 1221 19 increased increase VBN cord-335975-m6lkrehi 1221 20 hospital hospital NN cord-335975-m6lkrehi 1221 21 stay stay NN cord-335975-m6lkrehi 1221 22 , , , cord-335975-m6lkrehi 1221 23 increased increase VBN cord-335975-m6lkrehi 1221 24 cost cost NN cord-335975-m6lkrehi 1221 25 and and CC cord-335975-m6lkrehi 1221 26 long long JJ cord-335975-m6lkrehi 1221 27 term term NN cord-335975-m6lkrehi 1221 28 cognitive cognitive JJ cord-335975-m6lkrehi 1221 29 impairment impairment NN cord-335975-m6lkrehi 1221 30 in in IN cord-335975-m6lkrehi 1221 31 survivors survivor NNS cord-335975-m6lkrehi 1221 32 . . . cord-335975-m6lkrehi 1222 1 Numerous numerous JJ cord-335975-m6lkrehi 1222 2 pharmacological pharmacological JJ cord-335975-m6lkrehi 1222 3 and and CC cord-335975-m6lkrehi 1222 4 non non JJ cord-335975-m6lkrehi 1222 5 - - JJ cord-335975-m6lkrehi 1222 6 pharmacological pharmacological JJ cord-335975-m6lkrehi 1222 7 strategies strategy NNS cord-335975-m6lkrehi 1222 8 have have VBP cord-335975-m6lkrehi 1222 9 been be VBN cord-335975-m6lkrehi 1222 10 investigated investigate VBN cord-335975-m6lkrehi 1222 11 for for IN cord-335975-m6lkrehi 1222 12 delirium delirium NN cord-335975-m6lkrehi 1222 13 treatment treatment NN cord-335975-m6lkrehi 1222 14 without without IN cord-335975-m6lkrehi 1222 15 success success NN cord-335975-m6lkrehi 1222 16 . . . cord-335975-m6lkrehi 1223 1 Therefore therefore RB cord-335975-m6lkrehi 1223 2 delirium delirium NN cord-335975-m6lkrehi 1223 3 prevention prevention NN cord-335975-m6lkrehi 1223 4 strategies strategy NNS cord-335975-m6lkrehi 1223 5 are be VBP cord-335975-m6lkrehi 1223 6 recommended recommend VBN cord-335975-m6lkrehi 1223 7 by by IN cord-335975-m6lkrehi 1223 8 current current JJ cord-335975-m6lkrehi 1223 9 critical critical JJ cord-335975-m6lkrehi 1223 10 care care NN cord-335975-m6lkrehi 1223 11 practice practice NN cord-335975-m6lkrehi 1223 12 guidelines guideline NNS cord-335975-m6lkrehi 1223 13 . . . cord-335975-m6lkrehi 1224 1 Among among IN cord-335975-m6lkrehi 1224 2 the the DT cord-335975-m6lkrehi 1224 3 potentially potentially RB cord-335975-m6lkrehi 1224 4 modifiable modifiable JJ cord-335975-m6lkrehi 1224 5 risk risk NN cord-335975-m6lkrehi 1224 6 factors factor NNS cord-335975-m6lkrehi 1224 7 for for IN cord-335975-m6lkrehi 1224 8 delirium delirium NN cord-335975-m6lkrehi 1224 9 , , , cord-335975-m6lkrehi 1224 10 the the DT cord-335975-m6lkrehi 1224 11 impact impact NN cord-335975-m6lkrehi 1224 12 of of IN cord-335975-m6lkrehi 1224 13 daylight daylight NN cord-335975-m6lkrehi 1224 14 exposure exposure NN cord-335975-m6lkrehi 1224 15 on on IN cord-335975-m6lkrehi 1224 16 delirium delirium NN cord-335975-m6lkrehi 1224 17 incidence incidence NN cord-335975-m6lkrehi 1224 18 and and CC cord-335975-m6lkrehi 1224 19 or or CC cord-335975-m6lkrehi 1224 20 duration duration NN cord-335975-m6lkrehi 1224 21 has have VBZ cord-335975-m6lkrehi 1224 22 not not RB cord-335975-m6lkrehi 1224 23 been be VBN cord-335975-m6lkrehi 1224 24 studied study VBN cord-335975-m6lkrehi 1224 25 . . . cord-335975-m6lkrehi 1225 1 The the DT cord-335975-m6lkrehi 1225 2 objective objective NN cord-335975-m6lkrehi 1225 3 of of IN cord-335975-m6lkrehi 1225 4 this this DT cord-335975-m6lkrehi 1225 5 study study NN cord-335975-m6lkrehi 1225 6 was be VBD cord-335975-m6lkrehi 1225 7 to to TO cord-335975-m6lkrehi 1225 8 investigate investigate VB cord-335975-m6lkrehi 1225 9 whether whether IN cord-335975-m6lkrehi 1225 10 daylight daylight NN cord-335975-m6lkrehi 1225 11 exposition exposition NN cord-335975-m6lkrehi 1225 12 would would MD cord-335975-m6lkrehi 1225 13 reduce reduce VB cord-335975-m6lkrehi 1225 14 delirium delirium NN cord-335975-m6lkrehi 1225 15 burden burden NN cord-335975-m6lkrehi 1225 16 in in IN cord-335975-m6lkrehi 1225 17 critically critically RB cord-335975-m6lkrehi 1225 18 ill ill JJ cord-335975-m6lkrehi 1225 19 patients patient NNS cord-335975-m6lkrehi 1225 20 . . . cord-335975-m6lkrehi 1226 1 We -PRON- PRP cord-335975-m6lkrehi 1226 2 conducted conduct VBD cord-335975-m6lkrehi 1226 3 a a DT cord-335975-m6lkrehi 1226 4 prospective prospective JJ cord-335975-m6lkrehi 1226 5 study study NN cord-335975-m6lkrehi 1226 6 in in IN cord-335975-m6lkrehi 1226 7 a a DT cord-335975-m6lkrehi 1226 8 27-bed 27-bed CD cord-335975-m6lkrehi 1226 9 medical medical JJ cord-335975-m6lkrehi 1226 10 intensive intensive JJ cord-335975-m6lkrehi 1226 11 care care NN cord-335975-m6lkrehi 1226 12 unit unit NN cord-335975-m6lkrehi 1226 13 ( ( -LRB- cord-335975-m6lkrehi 1226 14 ICU ICU NNP cord-335975-m6lkrehi 1226 15 ) ) -RRB- cord-335975-m6lkrehi 1226 16 over over IN cord-335975-m6lkrehi 1226 17 a a DT cord-335975-m6lkrehi 1226 18 1-year 1-year CD cord-335975-m6lkrehi 1226 19 period period NN cord-335975-m6lkrehi 1226 20 ( ( -LRB- cord-335975-m6lkrehi 1226 21 January January NNP cord-335975-m6lkrehi 1226 22 2016-January 2016-january CD cord-335975-m6lkrehi 1226 23 2017 2017 CD cord-335975-m6lkrehi 1226 24 ) ) -RRB- cord-335975-m6lkrehi 1226 25 . . . cord-335975-m6lkrehi 1227 1 All all DT cord-335975-m6lkrehi 1227 2 consecutive consecutive JJ cord-335975-m6lkrehi 1227 3 adult adult NN cord-335975-m6lkrehi 1227 4 patients patient NNS cord-335975-m6lkrehi 1227 5 receiving receive VBG cord-335975-m6lkrehi 1227 6 invasive invasive JJ cord-335975-m6lkrehi 1227 7 mechanical mechanical JJ cord-335975-m6lkrehi 1227 8 ventilation ventilation NN cord-335975-m6lkrehi 1227 9 ( ( -LRB- cord-335975-m6lkrehi 1227 10 MV MV NNP cord-335975-m6lkrehi 1227 11 ) ) -RRB- cord-335975-m6lkrehi 1227 12 for for IN cord-335975-m6lkrehi 1227 13 2 2 CD cord-335975-m6lkrehi 1227 14 days day NNS cord-335975-m6lkrehi 1227 15 or or CC cord-335975-m6lkrehi 1227 16 more more RBR cord-335975-m6lkrehi 1227 17 were be VBD cord-335975-m6lkrehi 1227 18 eligible eligible JJ cord-335975-m6lkrehi 1227 19 for for IN cord-335975-m6lkrehi 1227 20 the the DT cord-335975-m6lkrehi 1227 21 study study NN cord-335975-m6lkrehi 1227 22 . . . cord-335975-m6lkrehi 1228 1 Patients patient NNS cord-335975-m6lkrehi 1228 2 were be VBD cord-335975-m6lkrehi 1228 3 assigned assign VBN cord-335975-m6lkrehi 1228 4 to to IN cord-335975-m6lkrehi 1228 5 a a DT cord-335975-m6lkrehi 1228 6 room room NN cord-335975-m6lkrehi 1228 7 with with IN cord-335975-m6lkrehi 1228 8 windows window NNS cord-335975-m6lkrehi 1228 9 allowing allow VBG cord-335975-m6lkrehi 1228 10 daylight daylight NN cord-335975-m6lkrehi 1228 11 exposure exposure NN cord-335975-m6lkrehi 1228 12 ( ( -LRB- cord-335975-m6lkrehi 1228 13 " " `` cord-335975-m6lkrehi 1228 14 Light light JJ cord-335975-m6lkrehi 1228 15 " " '' cord-335975-m6lkrehi 1228 16 group group NN cord-335975-m6lkrehi 1228 17 ) ) -RRB- cord-335975-m6lkrehi 1228 18 or or CC cord-335975-m6lkrehi 1228 19 without without IN cord-335975-m6lkrehi 1228 20 window window NN cord-335975-m6lkrehi 1228 21 ( ( -LRB- cord-335975-m6lkrehi 1228 22 " " `` cord-335975-m6lkrehi 1228 23 Dark dark JJ cord-335975-m6lkrehi 1228 24 " " '' cord-335975-m6lkrehi 1228 25 group group NN cord-335975-m6lkrehi 1228 26 ) ) -RRB- cord-335975-m6lkrehi 1228 27 , , , cord-335975-m6lkrehi 1228 28 depending depend VBG cord-335975-m6lkrehi 1228 29 on on IN cord-335975-m6lkrehi 1228 30 bed bed NN cord-335975-m6lkrehi 1228 31 availability availability NN cord-335975-m6lkrehi 1228 32 . . . cord-335975-m6lkrehi 1229 1 Delirium delirium NN cord-335975-m6lkrehi 1229 2 was be VBD cord-335975-m6lkrehi 1229 3 evaluated evaluate VBN cord-335975-m6lkrehi 1229 4 with with IN cord-335975-m6lkrehi 1229 5 the the DT cord-335975-m6lkrehi 1229 6 Intensive Intensive NNP cord-335975-m6lkrehi 1229 7 Care Care NNP cord-335975-m6lkrehi 1229 8 Delirium Delirium NNP cord-335975-m6lkrehi 1229 9 Screening Screening NNP cord-335975-m6lkrehi 1229 10 Checklist Checklist NNP cord-335975-m6lkrehi 1229 11 ( ( -LRB- cord-335975-m6lkrehi 1229 12 ICDSC ICDSC NNP cord-335975-m6lkrehi 1229 13 ) ) -RRB- cord-335975-m6lkrehi 1229 14 for for IN cord-335975-m6lkrehi 1229 15 a a DT cord-335975-m6lkrehi 1229 16 maximum maximum JJ cord-335975-m6lkrehi 1229 17 period period NN cord-335975-m6lkrehi 1229 18 of of IN cord-335975-m6lkrehi 1229 19 28 28 CD cord-335975-m6lkrehi 1229 20 days day NNS cord-335975-m6lkrehi 1229 21 . . . cord-335975-m6lkrehi 1230 1 Delirium delirium NN cord-335975-m6lkrehi 1230 2 was be VBD cord-335975-m6lkrehi 1230 3 defined define VBN cord-335975-m6lkrehi 1230 4 by by IN cord-335975-m6lkrehi 1230 5 a a DT cord-335975-m6lkrehi 1230 6 ICDSC ICDSC NNP cord-335975-m6lkrehi 1230 7 score score NN cord-335975-m6lkrehi 1230 8 ≥ ≥ CD cord-335975-m6lkrehi 1230 9 4 4 CD cord-335975-m6lkrehi 1230 10 for for IN cord-335975-m6lkrehi 1230 11 two two CD cord-335975-m6lkrehi 1230 12 consecutive consecutive JJ cord-335975-m6lkrehi 1230 13 days day NNS cord-335975-m6lkrehi 1230 14 . . . cord-335975-m6lkrehi 1231 1 Agitation agitation NN cord-335975-m6lkrehi 1231 2 was be VBD cord-335975-m6lkrehi 1231 3 defined define VBN cord-335975-m6lkrehi 1231 4 by by IN cord-335975-m6lkrehi 1231 5 a a DT cord-335975-m6lkrehi 1231 6 RASS RASS NNP cord-335975-m6lkrehi 1231 7 > > XX cord-335975-m6lkrehi 1231 8 or or CC cord-335975-m6lkrehi 1231 9 = = SYM cord-335975-m6lkrehi 1231 10 +2 +2 NN cord-335975-m6lkrehi 1231 11 . . . cord-335975-m6lkrehi 1232 1 The the DT cord-335975-m6lkrehi 1232 2 primary primary JJ cord-335975-m6lkrehi 1232 3 endpoint endpoint NN cord-335975-m6lkrehi 1232 4 was be VBD cord-335975-m6lkrehi 1232 5 cumulative cumulative JJ cord-335975-m6lkrehi 1232 6 incidence incidence NN cord-335975-m6lkrehi 1232 7 of of IN cord-335975-m6lkrehi 1232 8 delirium delirium NN cord-335975-m6lkrehi 1232 9 . . . cord-335975-m6lkrehi 1233 1 Data datum NNS cord-335975-m6lkrehi 1233 2 are be VBP cord-335975-m6lkrehi 1233 3 presented present VBN cord-335975-m6lkrehi 1233 4 as as IN cord-335975-m6lkrehi 1233 5 median median JJ cord-335975-m6lkrehi 1233 6 ( ( -LRB- cord-335975-m6lkrehi 1233 7 interquartile interquartile JJ cord-335975-m6lkrehi 1233 8 range range NN cord-335975-m6lkrehi 1233 9 ) ) -RRB- cord-335975-m6lkrehi 1233 10 or or CC cord-335975-m6lkrehi 1233 11 number number NN cord-335975-m6lkrehi 1233 12 ( ( -LRB- cord-335975-m6lkrehi 1233 13 percentage percentage NN cord-335975-m6lkrehi 1233 14 ) ) -RRB- cord-335975-m6lkrehi 1233 15 . . . cord-335975-m6lkrehi 1234 1 Results result NNS cord-335975-m6lkrehi 1234 2 : : : cord-335975-m6lkrehi 1235 1 A a DT cord-335975-m6lkrehi 1235 2 total total NN cord-335975-m6lkrehi 1235 3 of of IN cord-335975-m6lkrehi 1235 4 195 195 CD cord-335975-m6lkrehi 1235 5 patients patient NNS cord-335975-m6lkrehi 1235 6 were be VBD cord-335975-m6lkrehi 1235 7 included include VBN cord-335975-m6lkrehi 1235 8 ( ( -LRB- cord-335975-m6lkrehi 1235 9 age-50 age-50 NNP cord-335975-m6lkrehi 1235 10 [ [ -LRB- cord-335975-m6lkrehi 1235 11 50 50 CD cord-335975-m6lkrehi 1235 12 + + SYM cord-335975-m6lkrehi 1235 13 69 69 CD cord-335975-m6lkrehi 1235 14 ] ] -RRB- cord-335975-m6lkrehi 1235 15 years year NNS cord-335975-m6lkrehi 1235 16 , , , cord-335975-m6lkrehi 1235 17 SAPS2 SAPS2 NNP cord-335975-m6lkrehi 1235 18 - - HYPH cord-335975-m6lkrehi 1235 19 51 51 CD cord-335975-m6lkrehi 1235 20 [ [ -LRB- cord-335975-m6lkrehi 1235 21 36 36 CD cord-335975-m6lkrehi 1235 22 + + SYM cord-335975-m6lkrehi 1235 23 64 64 CD cord-335975-m6lkrehi 1235 24 ] ] -RRB- cord-335975-m6lkrehi 1235 25 , , , cord-335975-m6lkrehi 1235 26 SOFA SOFA NNP cord-335975-m6lkrehi 1235 27 score-9 score-9 NNP cord-335975-m6lkrehi 1235 28 [ [ -LRB- cord-335975-m6lkrehi 1235 29 7 7 CD cord-335975-m6lkrehi 1235 30 + + SYM cord-335975-m6lkrehi 1235 31 11 11 CD cord-335975-m6lkrehi 1235 32 ] ] -RRB- cord-335975-m6lkrehi 1235 33 , , , cord-335975-m6lkrehi 1235 34 medical medical JJ cord-335975-m6lkrehi 1235 35 admission-69 admission-69 CD cord-335975-m6lkrehi 1235 36 % % NN cord-335975-m6lkrehi 1235 37 ) ) -RRB- cord-335975-m6lkrehi 1235 38 . . . cord-335975-m6lkrehi 1236 1 Of of IN cord-335975-m6lkrehi 1236 2 them -PRON- PRP cord-335975-m6lkrehi 1236 3 , , , cord-335975-m6lkrehi 1236 4 110 110 CD cord-335975-m6lkrehi 1236 5 patients patient NNS cord-335975-m6lkrehi 1236 6 were be VBD cord-335975-m6lkrehi 1236 7 admitted admit VBN cord-335975-m6lkrehi 1236 8 to to IN cord-335975-m6lkrehi 1236 9 a a DT cord-335975-m6lkrehi 1236 10 " " `` cord-335975-m6lkrehi 1236 11 Light Light NNP cord-335975-m6lkrehi 1236 12 " " '' cord-335975-m6lkrehi 1236 13 group group NN cord-335975-m6lkrehi 1236 14 and and CC cord-335975-m6lkrehi 1236 15 85 85 CD cord-335975-m6lkrehi 1236 16 to to IN cord-335975-m6lkrehi 1236 17 a a DT cord-335975-m6lkrehi 1236 18 " " `` cord-335975-m6lkrehi 1236 19 Dark dark JJ cord-335975-m6lkrehi 1236 20 " " '' cord-335975-m6lkrehi 1236 21 group group NN cord-335975-m6lkrehi 1236 22 . . . cord-335975-m6lkrehi 1237 1 Incidence incidence NN cord-335975-m6lkrehi 1237 2 of of IN cord-335975-m6lkrehi 1237 3 known know VBN cord-335975-m6lkrehi 1237 4 risk risk NN cord-335975-m6lkrehi 1237 5 factors factor NNS cord-335975-m6lkrehi 1237 6 for for IN cord-335975-m6lkrehi 1237 7 delirium delirium NN cord-335975-m6lkrehi 1237 8 was be VBD cord-335975-m6lkrehi 1237 9 similar similar JJ cord-335975-m6lkrehi 1237 10 in in IN cord-335975-m6lkrehi 1237 11 the the DT cord-335975-m6lkrehi 1237 12 two two CD cord-335975-m6lkrehi 1237 13 groups group NNS cord-335975-m6lkrehi 1237 14 . . . cord-335975-m6lkrehi 1238 1 Delirium delirium NN cord-335975-m6lkrehi 1238 2 occurred occur VBD cord-335975-m6lkrehi 1238 3 in in IN cord-335975-m6lkrehi 1238 4 65 65 CD cord-335975-m6lkrehi 1238 5 ( ( -LRB- cord-335975-m6lkrehi 1238 6 64 64 CD cord-335975-m6lkrehi 1238 7 % % NN cord-335975-m6lkrehi 1238 8 ) ) -RRB- cord-335975-m6lkrehi 1238 9 patients patient NNS cord-335975-m6lkrehi 1238 10 in in IN cord-335975-m6lkrehi 1238 11 the the DT cord-335975-m6lkrehi 1238 12 " " `` cord-335975-m6lkrehi 1238 13 Light Light NNP cord-335975-m6lkrehi 1238 14 " " '' cord-335975-m6lkrehi 1238 15 group group NN cord-335975-m6lkrehi 1238 16 and and CC cord-335975-m6lkrehi 1238 17 in in IN cord-335975-m6lkrehi 1238 18 55 55 CD cord-335975-m6lkrehi 1238 19 ( ( -LRB- cord-335975-m6lkrehi 1238 20 71 71 CD cord-335975-m6lkrehi 1238 21 % % NN cord-335975-m6lkrehi 1238 22 ) ) -RRB- cord-335975-m6lkrehi 1238 23 patients patient NNS cord-335975-m6lkrehi 1238 24 in in IN cord-335975-m6lkrehi 1238 25 the the DT cord-335975-m6lkrehi 1238 26 " " `` cord-335975-m6lkrehi 1238 27 Dark dark JJ cord-335975-m6lkrehi 1238 28 " " '' cord-335975-m6lkrehi 1238 29 group group NN cord-335975-m6lkrehi 1238 30 ( ( -LRB- cord-335975-m6lkrehi 1238 31 p p NN cord-335975-m6lkrehi 1238 32 = = SYM cord-335975-m6lkrehi 1238 33 0.28 0.28 CD cord-335975-m6lkrehi 1238 34 ) ) -RRB- cord-335975-m6lkrehi 1238 35 . . . cord-335975-m6lkrehi 1239 1 The the DT cord-335975-m6lkrehi 1239 2 duration duration NN cord-335975-m6lkrehi 1239 3 of of IN cord-335975-m6lkrehi 1239 4 delirium delirium NN cord-335975-m6lkrehi 1239 5 was be VBD cord-335975-m6lkrehi 1239 6 3 3 CD cord-335975-m6lkrehi 1239 7 [ [ -LRB- cord-335975-m6lkrehi 1239 8 1 1 CD cord-335975-m6lkrehi 1239 9 + + SYM cord-335975-m6lkrehi 1239 10 7 7 CD cord-335975-m6lkrehi 1239 11 ] ] -RRB- cord-335975-m6lkrehi 1239 12 days day NNS cord-335975-m6lkrehi 1239 13 . . . cord-335975-m6lkrehi 1240 1 Patients patient NNS cord-335975-m6lkrehi 1240 2 in in IN cord-335975-m6lkrehi 1240 3 the the DT cord-335975-m6lkrehi 1240 4 " " `` cord-335975-m6lkrehi 1240 5 Light Light NNP cord-335975-m6lkrehi 1240 6 " " '' cord-335975-m6lkrehi 1240 7 group group NN cord-335975-m6lkrehi 1240 8 received receive VBD cord-335975-m6lkrehi 1240 9 significantly significantly RB cord-335975-m6lkrehi 1240 10 less less JJR cord-335975-m6lkrehi 1240 11 neuroleptics neuroleptic NNS cord-335975-m6lkrehi 1240 12 to to TO cord-335975-m6lkrehi 1240 13 treat treat VB cord-335975-m6lkrehi 1240 14 agitation agitation NN cord-335975-m6lkrehi 1240 15 than than IN cord-335975-m6lkrehi 1240 16 patients patient NNS cord-335975-m6lkrehi 1240 17 in in IN cord-335975-m6lkrehi 1240 18 the the DT cord-335975-m6lkrehi 1240 19 " " `` cord-335975-m6lkrehi 1240 20 Dark dark JJ cord-335975-m6lkrehi 1240 21 " " '' cord-335975-m6lkrehi 1240 22 group group NN cord-335975-m6lkrehi 1240 23 ( ( -LRB- cord-335975-m6lkrehi 1240 24 13 13 CD cord-335975-m6lkrehi 1240 25 vs. vs. IN cord-335975-m6lkrehi 1240 26 25 25 CD cord-335975-m6lkrehi 1240 27 % % NN cord-335975-m6lkrehi 1240 28 , , , cord-335975-m6lkrehi 1240 29 p p NN cord-335975-m6lkrehi 1240 30 = = SYM cord-335975-m6lkrehi 1240 31 0.04 0.04 CD cord-335975-m6lkrehi 1240 32 ) ) -RRB- cord-335975-m6lkrehi 1240 33 . . . cord-335975-m6lkrehi 1241 1 This this DT cord-335975-m6lkrehi 1241 2 protective protective JJ cord-335975-m6lkrehi 1241 3 association association NN cord-335975-m6lkrehi 1241 4 persisted persist VBD cord-335975-m6lkrehi 1241 5 after after IN cord-335975-m6lkrehi 1241 6 adjustment adjustment NN cord-335975-m6lkrehi 1241 7 for for IN cord-335975-m6lkrehi 1241 8 confounders confounder NNS cord-335975-m6lkrehi 1241 9 in in IN cord-335975-m6lkrehi 1241 10 multivariate multivariate JJ cord-335975-m6lkrehi 1241 11 analysis analysis NN cord-335975-m6lkrehi 1242 1 ( ( -LRB- cord-335975-m6lkrehi 1242 2 Odds odd NNS cord-335975-m6lkrehi 1242 3 ratio ratio NN cord-335975-m6lkrehi 1242 4 = = SYM cord-335975-m6lkrehi 1242 5 0.40 0.40 CD cord-335975-m6lkrehi 1242 6 + + CC cord-335975-m6lkrehi 1242 7 [ [ -LRB- cord-335975-m6lkrehi 1242 8 0.17 0.17 CD cord-335975-m6lkrehi 1242 9 + + SYM cord-335975-m6lkrehi 1242 10 0.90 0.90 CD cord-335975-m6lkrehi 1242 11 ] ] -RRB- cord-335975-m6lkrehi 1243 1 + + CC cord-335975-m6lkrehi 1243 2 p p NN cord-335975-m6lkrehi 1243 3 = = SYM cord-335975-m6lkrehi 1243 4 0.03 0.03 CD cord-335975-m6lkrehi 1243 5 ) ) -RRB- cord-335975-m6lkrehi 1243 6 . . . cord-335975-m6lkrehi 1244 1 Daylight daylight NN cord-335975-m6lkrehi 1244 2 exposure exposure NN cord-335975-m6lkrehi 1244 3 does do VBZ cord-335975-m6lkrehi 1244 4 not not RB cord-335975-m6lkrehi 1244 5 impact impact VB cord-335975-m6lkrehi 1244 6 on on IN cord-335975-m6lkrehi 1244 7 delirium delirium NN cord-335975-m6lkrehi 1244 8 burden burden NN cord-335975-m6lkrehi 1244 9 in in IN cord-335975-m6lkrehi 1244 10 ICU ICU NNP cord-335975-m6lkrehi 1244 11 mechanically mechanically RB cord-335975-m6lkrehi 1244 12 ventilated ventilate VBD cord-335975-m6lkrehi 1244 13 patients patient NNS cord-335975-m6lkrehi 1244 14 . . . cord-335975-m6lkrehi 1245 1 However however RB cord-335975-m6lkrehi 1245 2 , , , cord-335975-m6lkrehi 1245 3 daylight daylight NN cord-335975-m6lkrehi 1245 4 exposure exposure NN cord-335975-m6lkrehi 1245 5 is be VBZ cord-335975-m6lkrehi 1245 6 independently independently RB cord-335975-m6lkrehi 1245 7 associated associate VBN cord-335975-m6lkrehi 1245 8 with with IN cord-335975-m6lkrehi 1245 9 a a DT cord-335975-m6lkrehi 1245 10 reduced reduce VBN cord-335975-m6lkrehi 1245 11 prescription prescription NN cord-335975-m6lkrehi 1245 12 of of IN cord-335975-m6lkrehi 1245 13 neuroleptics neuroleptic NNS cord-335975-m6lkrehi 1245 14 to to TO cord-335975-m6lkrehi 1245 15 treat treat VB cord-335975-m6lkrehi 1245 16 agitation agitation NN cord-335975-m6lkrehi 1245 17 . . . cord-335975-m6lkrehi 1246 1 Introduction introduction NN cord-335975-m6lkrehi 1246 2 : : : cord-335975-m6lkrehi 1246 3 Patients patient NNS cord-335975-m6lkrehi 1246 4 with with IN cord-335975-m6lkrehi 1246 5 convulsive convulsive JJ cord-335975-m6lkrehi 1246 6 status status NN cord-335975-m6lkrehi 1246 7 epilepticus epilepticus NN cord-335975-m6lkrehi 1246 8 ( ( -LRB- cord-335975-m6lkrehi 1246 9 CSE CSE NNP cord-335975-m6lkrehi 1246 10 ) ) -RRB- cord-335975-m6lkrehi 1246 11 frequently frequently RB cord-335975-m6lkrehi 1246 12 require require VBP cord-335975-m6lkrehi 1246 13 mechanical mechanical JJ cord-335975-m6lkrehi 1246 14 ventilation ventilation NN cord-335975-m6lkrehi 1246 15 ( ( -LRB- cord-335975-m6lkrehi 1246 16 MV MV NNP cord-335975-m6lkrehi 1246 17 ) ) -RRB- cord-335975-m6lkrehi 1246 18 , , , cord-335975-m6lkrehi 1246 19 either either CC cord-335975-m6lkrehi 1246 20 for for IN cord-335975-m6lkrehi 1246 21 general general JJ cord-335975-m6lkrehi 1246 22 anesthesia anesthesia NN cord-335975-m6lkrehi 1246 23 in in IN cord-335975-m6lkrehi 1246 24 case case NN cord-335975-m6lkrehi 1246 25 of of IN cord-335975-m6lkrehi 1246 26 refractory refractory JJ cord-335975-m6lkrehi 1246 27 generalized generalize VBN cord-335975-m6lkrehi 1246 28 CSE CSE NNP cord-335975-m6lkrehi 1246 29 , , , cord-335975-m6lkrehi 1246 30 or or CC cord-335975-m6lkrehi 1246 31 for for IN cord-335975-m6lkrehi 1246 32 airway airway NN cord-335975-m6lkrehi 1246 33 protection protection NN cord-335975-m6lkrehi 1246 34 . . . cord-335975-m6lkrehi 1247 1 Guidelines guideline NNS cord-335975-m6lkrehi 1247 2 for for IN cord-335975-m6lkrehi 1247 3 the the DT cord-335975-m6lkrehi 1247 4 management management NN cord-335975-m6lkrehi 1247 5 of of IN cord-335975-m6lkrehi 1247 6 refractory refractory JJ cord-335975-m6lkrehi 1247 7 generalized generalize VBN cord-335975-m6lkrehi 1247 8 CSE CSE NNP cord-335975-m6lkrehi 1247 9 currently currently RB cord-335975-m6lkrehi 1247 10 recommend recommend VBP cord-335975-m6lkrehi 1247 11 general general JJ cord-335975-m6lkrehi 1247 12 anesthesia anesthesia NN cord-335975-m6lkrehi 1247 13 for for IN cord-335975-m6lkrehi 1247 14 24 24 CD cord-335975-m6lkrehi 1247 15 - - SYM cord-335975-m6lkrehi 1247 16 48 48 CD cord-335975-m6lkrehi 1247 17 h h NN cord-335975-m6lkrehi 1247 18 , , , cord-335975-m6lkrehi 1247 19 followed follow VBN cord-335975-m6lkrehi 1247 20 by by IN cord-335975-m6lkrehi 1247 21 gradual gradual JJ cord-335975-m6lkrehi 1247 22 withdrawal withdrawal NN cord-335975-m6lkrehi 1247 23 . . . cord-335975-m6lkrehi 1248 1 Our -PRON- PRP$ cord-335975-m6lkrehi 1248 2 objective objective NN cord-335975-m6lkrehi 1248 3 is be VBZ cord-335975-m6lkrehi 1248 4 to to TO cord-335975-m6lkrehi 1248 5 evaluate evaluate VB cord-335975-m6lkrehi 1248 6 the the DT cord-335975-m6lkrehi 1248 7 incidence incidence NN cord-335975-m6lkrehi 1248 8 of of IN cord-335975-m6lkrehi 1248 9 refractory refractory JJ cord-335975-m6lkrehi 1248 10 generalized generalize VBN cord-335975-m6lkrehi 1248 11 CSE CSE NNP cord-335975-m6lkrehi 1248 12 among among IN cord-335975-m6lkrehi 1248 13 patients patient NNS cord-335975-m6lkrehi 1248 14 who who WP cord-335975-m6lkrehi 1248 15 required require VBD cord-335975-m6lkrehi 1248 16 MV MV NNP cord-335975-m6lkrehi 1248 17 during during IN cord-335975-m6lkrehi 1248 18 pre pre JJ cord-335975-m6lkrehi 1248 19 - - JJ cord-335975-m6lkrehi 1248 20 hospital hospital JJ cord-335975-m6lkrehi 1248 21 management management NN cord-335975-m6lkrehi 1248 22 of of IN cord-335975-m6lkrehi 1248 23 status status NN cord-335975-m6lkrehi 1248 24 epilepticus epilepticus NN cord-335975-m6lkrehi 1248 25 , , , cord-335975-m6lkrehi 1248 26 and and CC cord-335975-m6lkrehi 1248 27 to to TO cord-335975-m6lkrehi 1248 28 describe describe VB cord-335975-m6lkrehi 1248 29 the the DT cord-335975-m6lkrehi 1248 30 management management NN cord-335975-m6lkrehi 1248 31 of of IN cord-335975-m6lkrehi 1248 32 general general JJ cord-335975-m6lkrehi 1248 33 anesthesia anesthesia NNP cord-335975-m6lkrehi 1248 34 in in IN cord-335975-m6lkrehi 1248 35 intensive intensive JJ cord-335975-m6lkrehi 1248 36 care care NN cord-335975-m6lkrehi 1248 37 unit unit NN cord-335975-m6lkrehi 1248 38 ( ( -LRB- cord-335975-m6lkrehi 1248 39 ICU ICU NNP cord-335975-m6lkrehi 1248 40 ) ) -RRB- cord-335975-m6lkrehi 1248 41 . . . cord-335975-m6lkrehi 1249 1 This this DT cord-335975-m6lkrehi 1249 2 ongoing ongoing JJ cord-335975-m6lkrehi 1249 3 multicenter multicenter JJ cord-335975-m6lkrehi 1249 4 retrospective retrospective JJ cord-335975-m6lkrehi 1249 5 observational observational JJ cord-335975-m6lkrehi 1249 6 study study NN cord-335975-m6lkrehi 1249 7 is be VBZ cord-335975-m6lkrehi 1249 8 conducted conduct VBN cord-335975-m6lkrehi 1249 9 in in IN cord-335975-m6lkrehi 1249 10 4 4 CD cord-335975-m6lkrehi 1249 11 French french JJ cord-335975-m6lkrehi 1249 12 ICUs icu NNS cord-335975-m6lkrehi 1249 13 . . . cord-335975-m6lkrehi 1250 1 All all DT cord-335975-m6lkrehi 1250 2 patients patient NNS cord-335975-m6lkrehi 1250 3 admitted admit VBD cord-335975-m6lkrehi 1250 4 in in IN cord-335975-m6lkrehi 1250 5 ICU ICU NNP cord-335975-m6lkrehi 1250 6 under under IN cord-335975-m6lkrehi 1250 7 mechanical mechanical JJ cord-335975-m6lkrehi 1250 8 ventilation ventilation NN cord-335975-m6lkrehi 1250 9 between between IN cord-335975-m6lkrehi 1250 10 01 01 CD cord-335975-m6lkrehi 1250 11 - - HYPH cord-335975-m6lkrehi 1250 12 01 01 CD cord-335975-m6lkrehi 1250 13 - - HYPH cord-335975-m6lkrehi 1250 14 2014 2014 CD cord-335975-m6lkrehi 1250 15 and and CC cord-335975-m6lkrehi 1250 16 12 12 CD cord-335975-m6lkrehi 1250 17 - - SYM cord-335975-m6lkrehi 1250 18 31 31 CD cord-335975-m6lkrehi 1250 19 - - HYPH cord-335975-m6lkrehi 1250 20 2016 2016 CD cord-335975-m6lkrehi 1250 21 with with IN cord-335975-m6lkrehi 1250 22 disease disease NN cord-335975-m6lkrehi 1250 23 - - HYPH cord-335975-m6lkrehi 1250 24 code code NN cord-335975-m6lkrehi 1250 25 " " `` cord-335975-m6lkrehi 1250 26 Status Status NNP cord-335975-m6lkrehi 1250 27 Epilepticus Epilepticus NNP cord-335975-m6lkrehi 1250 28 " " '' cord-335975-m6lkrehi 1250 29 are be VBP cord-335975-m6lkrehi 1250 30 included include VBN cord-335975-m6lkrehi 1250 31 . . . cord-335975-m6lkrehi 1251 1 Exclusion exclusion NN cord-335975-m6lkrehi 1251 2 criteria criterion NNS cord-335975-m6lkrehi 1251 3 are be VBP cord-335975-m6lkrehi 1251 4 - - : cord-335975-m6lkrehi 1251 5 age age NN cord-335975-m6lkrehi 1251 6 < < XX cord-335975-m6lkrehi 1251 7 18 18 CD cord-335975-m6lkrehi 1251 8 years year NNS cord-335975-m6lkrehi 1251 9 , , , cord-335975-m6lkrehi 1251 10 post post VB cord-335975-m6lkrehi 1251 11 anoxic anoxic JJ cord-335975-m6lkrehi 1251 12 SE SE NNP cord-335975-m6lkrehi 1251 13 , , , cord-335975-m6lkrehi 1251 14 acute acute JJ cord-335975-m6lkrehi 1251 15 traumatic traumatic JJ cord-335975-m6lkrehi 1251 16 brain brain NN cord-335975-m6lkrehi 1251 17 injury injury NN cord-335975-m6lkrehi 1251 18 , , , cord-335975-m6lkrehi 1251 19 initiation initiation NN cord-335975-m6lkrehi 1251 20 of of IN cord-335975-m6lkrehi 1251 21 MV MV NNP cord-335975-m6lkrehi 1251 22 in in IN cord-335975-m6lkrehi 1251 23 ICU ICU NNP cord-335975-m6lkrehi 1251 24 , , , cord-335975-m6lkrehi 1251 25 transfer transfer NN cord-335975-m6lkrehi 1251 26 from from IN cord-335975-m6lkrehi 1251 27 another another DT cord-335975-m6lkrehi 1251 28 ICU ICU NNP cord-335975-m6lkrehi 1251 29 , , , cord-335975-m6lkrehi 1251 30 inclusion inclusion NN cord-335975-m6lkrehi 1251 31 in in IN cord-335975-m6lkrehi 1251 32 a a DT cord-335975-m6lkrehi 1251 33 therapeutic therapeutic JJ cord-335975-m6lkrehi 1251 34 trial trial NN cord-335975-m6lkrehi 1251 35 on on IN cord-335975-m6lkrehi 1251 36 SE SE NNP cord-335975-m6lkrehi 1251 37 , , , cord-335975-m6lkrehi 1251 38 non non JJ cord-335975-m6lkrehi 1251 39 - - JJ cord-335975-m6lkrehi 1251 40 convulsive convulsive JJ cord-335975-m6lkrehi 1251 41 SE se NN cord-335975-m6lkrehi 1251 42 . . . cord-335975-m6lkrehi 1252 1 Collected collect VBN cord-335975-m6lkrehi 1252 2 data datum NNS cord-335975-m6lkrehi 1252 3 include include VBP cord-335975-m6lkrehi 1252 4 reason reason NN cord-335975-m6lkrehi 1252 5 for for IN cord-335975-m6lkrehi 1252 6 MV MV NNP cord-335975-m6lkrehi 1252 7 , , , cord-335975-m6lkrehi 1252 8 antiepileptic antiepileptic JJ cord-335975-m6lkrehi 1252 9 treatment treatment NN cord-335975-m6lkrehi 1252 10 , , , cord-335975-m6lkrehi 1252 11 dosage dosage NN cord-335975-m6lkrehi 1252 12 and and CC cord-335975-m6lkrehi 1252 13 duration duration NN cord-335975-m6lkrehi 1252 14 of of IN cord-335975-m6lkrehi 1252 15 general general JJ cord-335975-m6lkrehi 1252 16 anesthesia anesthesia NN cord-335975-m6lkrehi 1252 17 , , , cord-335975-m6lkrehi 1252 18 mode mode NN cord-335975-m6lkrehi 1252 19 of of IN cord-335975-m6lkrehi 1252 20 EEG EEG NNP cord-335975-m6lkrehi 1252 21 monitoring monitoring NN cord-335975-m6lkrehi 1252 22 . . . cord-335975-m6lkrehi 1253 1 Outcomes outcome NNS cord-335975-m6lkrehi 1253 2 are be VBP cord-335975-m6lkrehi 1253 3 - - : cord-335975-m6lkrehi 1253 4 relapse relapse NN cord-335975-m6lkrehi 1253 5 of of IN cord-335975-m6lkrehi 1253 6 SE SE NNP cord-335975-m6lkrehi 1253 7 , , , cord-335975-m6lkrehi 1253 8 MV MV NNP cord-335975-m6lkrehi 1253 9 duration duration NN cord-335975-m6lkrehi 1253 10 , , , cord-335975-m6lkrehi 1253 11 in in IN cord-335975-m6lkrehi 1253 12 - - HYPH cord-335975-m6lkrehi 1253 13 ICU ICU NNP cord-335975-m6lkrehi 1253 14 length length NN cord-335975-m6lkrehi 1253 15 of of IN cord-335975-m6lkrehi 1253 16 stay stay NN cord-335975-m6lkrehi 1253 17 and and CC cord-335975-m6lkrehi 1253 18 mortality mortality NN cord-335975-m6lkrehi 1253 19 . . . cord-335975-m6lkrehi 1254 1 Results result NNS cord-335975-m6lkrehi 1254 2 : : : cord-335975-m6lkrehi 1255 1 Among among IN cord-335975-m6lkrehi 1255 2 the the DT cord-335975-m6lkrehi 1255 3 211 211 CD cord-335975-m6lkrehi 1255 4 medical medical JJ cord-335975-m6lkrehi 1255 5 files file NNS cord-335975-m6lkrehi 1255 6 reviewed review VBN cord-335975-m6lkrehi 1255 7 , , , cord-335975-m6lkrehi 1255 8 77 77 CD cord-335975-m6lkrehi 1255 9 met meet VBD cord-335975-m6lkrehi 1255 10 the the DT cord-335975-m6lkrehi 1255 11 inclusion inclusion NN cord-335975-m6lkrehi 1255 12 criteria criterion NNS cord-335975-m6lkrehi 1255 13 and and CC cord-335975-m6lkrehi 1255 14 were be VBD cord-335975-m6lkrehi 1255 15 analyzed analyze VBN cord-335975-m6lkrehi 1255 16 , , , cord-335975-m6lkrehi 1255 17 and and CC cord-335975-m6lkrehi 1255 18 134 134 CD cord-335975-m6lkrehi 1255 19 were be VBD cord-335975-m6lkrehi 1255 20 excluded exclude VBN cord-335975-m6lkrehi 1255 21 . . . cord-335975-m6lkrehi 1256 1 A a DT cord-335975-m6lkrehi 1256 2 minority minority NN cord-335975-m6lkrehi 1256 3 of of IN cord-335975-m6lkrehi 1256 4 patients patient NNS cord-335975-m6lkrehi 1256 5 ( ( -LRB- cord-335975-m6lkrehi 1256 6 18.2 18.2 CD cord-335975-m6lkrehi 1256 7 % % NN cord-335975-m6lkrehi 1256 8 ) ) -RRB- cord-335975-m6lkrehi 1256 9 had have VBD cord-335975-m6lkrehi 1256 10 a a DT cord-335975-m6lkrehi 1256 11 refractory refractory JJ cord-335975-m6lkrehi 1256 12 generalized generalize VBN cord-335975-m6lkrehi 1256 13 CSE CSE NNP cord-335975-m6lkrehi 1256 14 , , , cord-335975-m6lkrehi 1256 15 most most JJS cord-335975-m6lkrehi 1256 16 patients patient NNS cord-335975-m6lkrehi 1256 17 ( ( -LRB- cord-335975-m6lkrehi 1256 18 64.9 64.9 CD cord-335975-m6lkrehi 1256 19 % % NN cord-335975-m6lkrehi 1256 20 ) ) -RRB- cord-335975-m6lkrehi 1256 21 had have VBD cord-335975-m6lkrehi 1256 22 a a DT cord-335975-m6lkrehi 1256 23 non non JJ cord-335975-m6lkrehi 1256 24 - - JJ cord-335975-m6lkrehi 1256 25 refractory refractory JJ cord-335975-m6lkrehi 1256 26 generalized generalize VBN cord-335975-m6lkrehi 1256 27 CSE CSE NNP cord-335975-m6lkrehi 1256 28 + + CC cord-335975-m6lkrehi 1256 29 the the DT cord-335975-m6lkrehi 1256 30 others other NNS cord-335975-m6lkrehi 1256 31 had have VBD cord-335975-m6lkrehi 1256 32 mostly mostly RB cord-335975-m6lkrehi 1256 33 partial partial JJ cord-335975-m6lkrehi 1256 34 CSE CSE NNP cord-335975-m6lkrehi 1256 35 . . . cord-335975-m6lkrehi 1257 1 The the DT cord-335975-m6lkrehi 1257 2 main main JJ cord-335975-m6lkrehi 1257 3 reason reason NN cord-335975-m6lkrehi 1257 4 for for IN cord-335975-m6lkrehi 1257 5 intubation intubation NN cord-335975-m6lkrehi 1257 6 was be VBD cord-335975-m6lkrehi 1257 7 coma coma NN cord-335975-m6lkrehi 1257 8 ( ( -LRB- cord-335975-m6lkrehi 1257 9 n n NN cord-335975-m6lkrehi 1257 10 = = SYM cord-335975-m6lkrehi 1257 11 45 45 CD cord-335975-m6lkrehi 1257 12 , , , cord-335975-m6lkrehi 1257 13 58.4 58.4 CD cord-335975-m6lkrehi 1257 14 % % NN cord-335975-m6lkrehi 1257 15 ) ) -RRB- cord-335975-m6lkrehi 1257 16 . . . cord-335975-m6lkrehi 1258 1 The the DT cord-335975-m6lkrehi 1258 2 duration duration NN cord-335975-m6lkrehi 1258 3 of of IN cord-335975-m6lkrehi 1258 4 general general JJ cord-335975-m6lkrehi 1258 5 anesthesia anesthesia NN cord-335975-m6lkrehi 1258 6 was be VBD cord-335975-m6lkrehi 1258 7 not not RB cord-335975-m6lkrehi 1258 8 significantly significantly RB cord-335975-m6lkrehi 1258 9 different different JJ cord-335975-m6lkrehi 1258 10 in in IN cord-335975-m6lkrehi 1258 11 refractory refractory JJ cord-335975-m6lkrehi 1258 12 CSE CSE NNP cord-335975-m6lkrehi 1258 13 patients patient NNS cord-335975-m6lkrehi 1258 14 compared compare VBN cord-335975-m6lkrehi 1258 15 to to IN cord-335975-m6lkrehi 1258 16 non non JJ cord-335975-m6lkrehi 1258 17 - - JJ cord-335975-m6lkrehi 1258 18 refractory refractory JJ cord-335975-m6lkrehi 1258 19 CSE CSE NNP cord-335975-m6lkrehi 1258 20 patients patient NNS cord-335975-m6lkrehi 1258 21 ( ( -LRB- cord-335975-m6lkrehi 1258 22 p p NN cord-335975-m6lkrehi 1258 23 = = SYM cord-335975-m6lkrehi 1258 24 0.18 0.18 CD cord-335975-m6lkrehi 1258 25 ) ) -RRB- cord-335975-m6lkrehi 1258 26 . . . cord-335975-m6lkrehi 1259 1 Data datum NNS cord-335975-m6lkrehi 1259 2 regarding regard VBG cord-335975-m6lkrehi 1259 3 main main JJ cord-335975-m6lkrehi 1259 4 outcomes outcome NNS cord-335975-m6lkrehi 1259 5 are be VBP cord-335975-m6lkrehi 1259 6 summarized summarize VBN cord-335975-m6lkrehi 1259 7 below- below- RB cord-335975-m6lkrehi 1259 8 . . . cord-335975-m6lkrehi 1260 1 These these DT cord-335975-m6lkrehi 1260 2 preliminary preliminary JJ cord-335975-m6lkrehi 1260 3 data datum NNS cord-335975-m6lkrehi 1260 4 suggest suggest VBP cord-335975-m6lkrehi 1260 5 that that IN cord-335975-m6lkrehi 1260 6 the the DT cord-335975-m6lkrehi 1260 7 majority majority NN cord-335975-m6lkrehi 1260 8 of of IN cord-335975-m6lkrehi 1260 9 the the DT cord-335975-m6lkrehi 1260 10 patients patient NNS cord-335975-m6lkrehi 1260 11 admitted admit VBN cord-335975-m6lkrehi 1260 12 in in IN cord-335975-m6lkrehi 1260 13 ICU ICU NNP cord-335975-m6lkrehi 1260 14 under under IN cord-335975-m6lkrehi 1260 15 MV MV NNP cord-335975-m6lkrehi 1260 16 for for IN cord-335975-m6lkrehi 1260 17 CSE CSE NNP cord-335975-m6lkrehi 1260 18 do do VBP cord-335975-m6lkrehi 1260 19 not not RB cord-335975-m6lkrehi 1260 20 have have VB cord-335975-m6lkrehi 1260 21 a a DT cord-335975-m6lkrehi 1260 22 refractory refractory JJ cord-335975-m6lkrehi 1260 23 status status NN cord-335975-m6lkrehi 1260 24 . . . cord-335975-m6lkrehi 1261 1 Indication indication NN cord-335975-m6lkrehi 1261 2 of of IN cord-335975-m6lkrehi 1261 3 MV MV NNP cord-335975-m6lkrehi 1261 4 is be VBZ cord-335975-m6lkrehi 1261 5 mainly mainly RB cord-335975-m6lkrehi 1261 6 coma coma NN cord-335975-m6lkrehi 1261 7 without without IN cord-335975-m6lkrehi 1261 8 persistent persistent JJ cord-335975-m6lkrehi 1261 9 convulsions convulsion NNS cord-335975-m6lkrehi 1261 10 . . . cord-335975-m6lkrehi 1262 1 The the DT cord-335975-m6lkrehi 1262 2 mean mean JJ cord-335975-m6lkrehi 1262 3 duration duration NN cord-335975-m6lkrehi 1262 4 of of IN cord-335975-m6lkrehi 1262 5 general general JJ cord-335975-m6lkrehi 1262 6 anesthesia anesthesia NN cord-335975-m6lkrehi 1262 7 before before IN cord-335975-m6lkrehi 1262 8 withdrawal withdrawal NN cord-335975-m6lkrehi 1262 9 is be VBZ cord-335975-m6lkrehi 1262 10 < < NNP cord-335975-m6lkrehi 1262 11 24 24 CD cord-335975-m6lkrehi 1262 12 h h NNP cord-335975-m6lkrehi 1262 13 , , , cord-335975-m6lkrehi 1262 14 and and CC cord-335975-m6lkrehi 1262 15 thus thus RB cord-335975-m6lkrehi 1262 16 in in IN cord-335975-m6lkrehi 1262 17 discrepancy discrepancy NN cord-335975-m6lkrehi 1262 18 with with IN cord-335975-m6lkrehi 1262 19 guidelines guideline NNS cord-335975-m6lkrehi 1262 20 , , , cord-335975-m6lkrehi 1262 21 but but CC cord-335975-m6lkrehi 1262 22 does do VBZ cord-335975-m6lkrehi 1262 23 not not RB cord-335975-m6lkrehi 1262 24 seem seem VB cord-335975-m6lkrehi 1262 25 associated associate VBN cord-335975-m6lkrehi 1262 26 with with IN cord-335975-m6lkrehi 1262 27 a a DT cord-335975-m6lkrehi 1262 28 frequent frequent JJ cord-335975-m6lkrehi 1262 29 relapse relapse NN cord-335975-m6lkrehi 1262 30 of of IN cord-335975-m6lkrehi 1262 31 SE SE NNP cord-335975-m6lkrehi 1262 32 . . . cord-335975-m6lkrehi 1263 1 If if IN cord-335975-m6lkrehi 1263 2 this this DT cord-335975-m6lkrehi 1263 3 low low JJ cord-335975-m6lkrehi 1263 4 rate rate NN cord-335975-m6lkrehi 1263 5 of of IN cord-335975-m6lkrehi 1263 6 RSE rse NN cord-335975-m6lkrehi 1263 7 for for IN cord-335975-m6lkrehi 1263 8 patients patient NNS cord-335975-m6lkrehi 1263 9 admitted admit VBN cord-335975-m6lkrehi 1263 10 in in IN cord-335975-m6lkrehi 1263 11 ICU ICU NNP cord-335975-m6lkrehi 1263 12 and and CC cord-335975-m6lkrehi 1263 13 the the DT cord-335975-m6lkrehi 1263 14 safety safety NN cord-335975-m6lkrehi 1263 15 of of IN cord-335975-m6lkrehi 1263 16 rapid rapid JJ cord-335975-m6lkrehi 1263 17 withdrawal withdrawal NN cord-335975-m6lkrehi 1263 18 of of IN cord-335975-m6lkrehi 1263 19 GA GA NNP cord-335975-m6lkrehi 1263 20 are be VBP cord-335975-m6lkrehi 1263 21 confirmed confirm VBN cord-335975-m6lkrehi 1263 22 , , , cord-335975-m6lkrehi 1263 23 the the DT cord-335975-m6lkrehi 1263 24 recommended recommend VBN cord-335975-m6lkrehi 1263 25 24 24 CD cord-335975-m6lkrehi 1263 26 - - SYM cord-335975-m6lkrehi 1263 27 48 48 CD cord-335975-m6lkrehi 1263 28 h h NN cord-335975-m6lkrehi 1263 29 duration duration NN cord-335975-m6lkrehi 1263 30 of of IN cord-335975-m6lkrehi 1263 31 general general JJ cord-335975-m6lkrehi 1263 32 anesthesia anesthesia NN cord-335975-m6lkrehi 1263 33 in in IN cord-335975-m6lkrehi 1263 34 ICU ICU NNP cord-335975-m6lkrehi 1263 35 could could MD cord-335975-m6lkrehi 1263 36 be be VB cord-335975-m6lkrehi 1263 37 challenged challenge VBN cord-335975-m6lkrehi 1263 38 . . . cord-335975-m6lkrehi 1264 1 Introduction introduction NN cord-335975-m6lkrehi 1264 2 : : : cord-335975-m6lkrehi 1265 1 Induced induce VBN cord-335975-m6lkrehi 1265 2 coma coma NN cord-335975-m6lkrehi 1265 3 in in IN cord-335975-m6lkrehi 1265 4 intensive intensive JJ cord-335975-m6lkrehi 1265 5 care care NN cord-335975-m6lkrehi 1265 6 patients patient NNS cord-335975-m6lkrehi 1265 7 protect protect VBP cord-335975-m6lkrehi 1265 8 them -PRON- PRP cord-335975-m6lkrehi 1265 9 against against IN cord-335975-m6lkrehi 1265 10 pain pain NN cord-335975-m6lkrehi 1265 11 and and CC cord-335975-m6lkrehi 1265 12 neurologic neurologic JJ cord-335975-m6lkrehi 1265 13 disorders disorder NNS cord-335975-m6lkrehi 1265 14 . . . cord-335975-m6lkrehi 1266 1 However however RB cord-335975-m6lkrehi 1266 2 , , , cord-335975-m6lkrehi 1266 3 a a DT cord-335975-m6lkrehi 1266 4 few few JJ cord-335975-m6lkrehi 1266 5 of of IN cord-335975-m6lkrehi 1266 6 them -PRON- PRP cord-335975-m6lkrehi 1266 7 may may MD cord-335975-m6lkrehi 1266 8 present present VB cord-335975-m6lkrehi 1266 9 a a DT cord-335975-m6lkrehi 1266 10 delayed delay VBN cord-335975-m6lkrehi 1266 11 wake wake NN cord-335975-m6lkrehi 1266 12 - - HYPH cord-335975-m6lkrehi 1266 13 up up NN cord-335975-m6lkrehi 1266 14 when when WRB cord-335975-m6lkrehi 1266 15 the the DT cord-335975-m6lkrehi 1266 16 sedation sedation NN cord-335975-m6lkrehi 1266 17 is be VBZ cord-335975-m6lkrehi 1266 18 interrupted interrupt VBN cord-335975-m6lkrehi 1266 19 . . . cord-335975-m6lkrehi 1267 1 The the DT cord-335975-m6lkrehi 1267 2 aim aim NN cord-335975-m6lkrehi 1267 3 of of IN cord-335975-m6lkrehi 1267 4 this this DT cord-335975-m6lkrehi 1267 5 work work NN cord-335975-m6lkrehi 1267 6 is be VBZ cord-335975-m6lkrehi 1267 7 to to TO cord-335975-m6lkrehi 1267 8 assess assess VB cord-335975-m6lkrehi 1267 9 brain brain NN cord-335975-m6lkrehi 1267 10 imaging image VBG cord-335975-m6lkrehi 1267 11 findings finding NNS cord-335975-m6lkrehi 1267 12 in in IN cord-335975-m6lkrehi 1267 13 patients patient NNS cord-335975-m6lkrehi 1267 14 with with IN cord-335975-m6lkrehi 1267 15 this this DT cord-335975-m6lkrehi 1267 16 condition condition NN cord-335975-m6lkrehi 1267 17 . . . cord-335975-m6lkrehi 1268 1 Patients patient NNS cord-335975-m6lkrehi 1268 2 and and CC cord-335975-m6lkrehi 1268 3 methods method NNS cord-335975-m6lkrehi 1268 4 : : : cord-335975-m6lkrehi 1268 5 Retrospective retrospective JJ cord-335975-m6lkrehi 1268 6 review review NN cord-335975-m6lkrehi 1268 7 of of IN cord-335975-m6lkrehi 1268 8 imaging image VBG cord-335975-m6lkrehi 1268 9 data datum NNS cord-335975-m6lkrehi 1268 10 of of IN cord-335975-m6lkrehi 1268 11 27 27 CD cord-335975-m6lkrehi 1268 12 patients patient NNS cord-335975-m6lkrehi 1268 13 ( ( -LRB- cord-335975-m6lkrehi 1268 14 21 21 CD cord-335975-m6lkrehi 1268 15 males male NNS cord-335975-m6lkrehi 1268 16 and and CC cord-335975-m6lkrehi 1268 17 6 6 CD cord-335975-m6lkrehi 1268 18 females female NNS cord-335975-m6lkrehi 1268 19 ) ) -RRB- cord-335975-m6lkrehi 1268 20 , , , cord-335975-m6lkrehi 1268 21 aged age VBN cord-335975-m6lkrehi 1268 22 between between IN cord-335975-m6lkrehi 1268 23 32 32 CD cord-335975-m6lkrehi 1268 24 and and CC cord-335975-m6lkrehi 1268 25 84 84 CD cord-335975-m6lkrehi 1268 26 years year NNS cord-335975-m6lkrehi 1268 27 , , , cord-335975-m6lkrehi 1268 28 admitted admit VBN cord-335975-m6lkrehi 1268 29 in in IN cord-335975-m6lkrehi 1268 30 intensive intensive JJ cord-335975-m6lkrehi 1268 31 care care NN cord-335975-m6lkrehi 1268 32 unit unit NN cord-335975-m6lkrehi 1268 33 ( ( -LRB- cord-335975-m6lkrehi 1268 34 ICU ICU NNP cord-335975-m6lkrehi 1268 35 ) ) -RRB- cord-335975-m6lkrehi 1268 36 between between IN cord-335975-m6lkrehi 1268 37 June June NNP cord-335975-m6lkrehi 1268 38 2015 2015 CD cord-335975-m6lkrehi 1268 39 and and CC cord-335975-m6lkrehi 1268 40 September September NNP cord-335975-m6lkrehi 1268 41 2017 2017 CD cord-335975-m6lkrehi 1268 42 , , , cord-335975-m6lkrehi 1268 43 who who WP cord-335975-m6lkrehi 1268 44 had have VBD cord-335975-m6lkrehi 1268 45 sedation sedation NN cord-335975-m6lkrehi 1268 46 or or CC cord-335975-m6lkrehi 1268 47 general general JJ cord-335975-m6lkrehi 1268 48 anesthesia anesthesia NN cord-335975-m6lkrehi 1268 49 and and CC cord-335975-m6lkrehi 1268 50 presented present VBD cord-335975-m6lkrehi 1268 51 a a DT cord-335975-m6lkrehi 1268 52 delayed delay VBN cord-335975-m6lkrehi 1268 53 wake wake NN cord-335975-m6lkrehi 1268 54 - - HYPH cord-335975-m6lkrehi 1268 55 up up NN cord-335975-m6lkrehi 1268 56 . . . cord-335975-m6lkrehi 1269 1 They -PRON- PRP cord-335975-m6lkrehi 1269 2 were be VBD cord-335975-m6lkrehi 1269 3 explored explore VBN cord-335975-m6lkrehi 1269 4 either either CC cord-335975-m6lkrehi 1269 5 by by IN cord-335975-m6lkrehi 1269 6 MRI MRI NNP cord-335975-m6lkrehi 1269 7 ( ( -LRB- cord-335975-m6lkrehi 1269 8 n n NN cord-335975-m6lkrehi 1269 9 = = SYM cord-335975-m6lkrehi 1269 10 11 11 CD cord-335975-m6lkrehi 1269 11 ) ) -RRB- cord-335975-m6lkrehi 1269 12 or or CC cord-335975-m6lkrehi 1269 13 computed compute VBN cord-335975-m6lkrehi 1269 14 tomography tomography NN cord-335975-m6lkrehi 1269 15 ( ( -LRB- cord-335975-m6lkrehi 1269 16 CT CT NNP cord-335975-m6lkrehi 1269 17 ) ) -RRB- cord-335975-m6lkrehi 1270 1 ( ( -LRB- cord-335975-m6lkrehi 1270 2 n n NN cord-335975-m6lkrehi 1270 3 = = SYM cord-335975-m6lkrehi 1270 4 16 16 CD cord-335975-m6lkrehi 1270 5 ) ) -RRB- cord-335975-m6lkrehi 1270 6 . . . cord-335975-m6lkrehi 1271 1 Patients patient NNS cord-335975-m6lkrehi 1271 2 with with IN cord-335975-m6lkrehi 1271 3 traumatic traumatic JJ cord-335975-m6lkrehi 1271 4 lesions lesion NNS cord-335975-m6lkrehi 1271 5 were be VBD cord-335975-m6lkrehi 1271 6 excluded exclude VBN cord-335975-m6lkrehi 1271 7 . . . cord-335975-m6lkrehi 1272 1 Results result NNS cord-335975-m6lkrehi 1272 2 : : : cord-335975-m6lkrehi 1273 1 Patients patient NNS cord-335975-m6lkrehi 1273 2 were be VBD cord-335975-m6lkrehi 1273 3 admitted admit VBN cord-335975-m6lkrehi 1273 4 in in IN cord-335975-m6lkrehi 1273 5 the the DT cord-335975-m6lkrehi 1273 6 ICU ICU NNP cord-335975-m6lkrehi 1273 7 because because IN cord-335975-m6lkrehi 1273 8 of of IN cord-335975-m6lkrehi 1273 9 chronic chronic JJ cord-335975-m6lkrehi 1273 10 obstructive obstructive JJ cord-335975-m6lkrehi 1273 11 pulmonary pulmonary JJ cord-335975-m6lkrehi 1273 12 disease disease NN cord-335975-m6lkrehi 1273 13 exacerbation exacerbation NN cord-335975-m6lkrehi 1273 14 ( ( -LRB- cord-335975-m6lkrehi 1273 15 n n NN cord-335975-m6lkrehi 1273 16 = = SYM cord-335975-m6lkrehi 1273 17 7 7 CD cord-335975-m6lkrehi 1273 18 ) ) -RRB- cord-335975-m6lkrehi 1273 19 , , , cord-335975-m6lkrehi 1273 20 infectious infectious JJ cord-335975-m6lkrehi 1273 21 pneumonia pneumonia NN cord-335975-m6lkrehi 1273 22 or or CC cord-335975-m6lkrehi 1273 23 pleural pleural JJ cord-335975-m6lkrehi 1273 24 effusion effusion NN cord-335975-m6lkrehi 1273 25 ( ( -LRB- cord-335975-m6lkrehi 1273 26 n n NN cord-335975-m6lkrehi 1273 27 = = SYM cord-335975-m6lkrehi 1273 28 6 6 CD cord-335975-m6lkrehi 1273 29 ) ) -RRB- cord-335975-m6lkrehi 1273 30 , , , cord-335975-m6lkrehi 1273 31 acute acute JJ cord-335975-m6lkrehi 1273 32 respiratory respiratory JJ cord-335975-m6lkrehi 1273 33 failure failure NN cord-335975-m6lkrehi 1273 34 ( ( -LRB- cord-335975-m6lkrehi 1273 35 n n NN cord-335975-m6lkrehi 1273 36 = = SYM cord-335975-m6lkrehi 1273 37 5 5 CD cord-335975-m6lkrehi 1273 38 ) ) -RRB- cord-335975-m6lkrehi 1273 39 , , , cord-335975-m6lkrehi 1273 40 heart heart NN cord-335975-m6lkrehi 1273 41 disease disease NN cord-335975-m6lkrehi 1273 42 ( ( -LRB- cord-335975-m6lkrehi 1273 43 n n NN cord-335975-m6lkrehi 1273 44 = = SYM cord-335975-m6lkrehi 1273 45 2 2 CD cord-335975-m6lkrehi 1273 46 ) ) -RRB- cord-335975-m6lkrehi 1273 47 . . . cord-335975-m6lkrehi 1274 1 Two two CD cord-335975-m6lkrehi 1274 2 patients patient NNS cord-335975-m6lkrehi 1274 3 underwent undergo VBD cord-335975-m6lkrehi 1274 4 general general JJ cord-335975-m6lkrehi 1274 5 anesthesia anesthesia NNS cord-335975-m6lkrehi 1274 6 . . . cord-335975-m6lkrehi 1275 1 Septic septic JJ cord-335975-m6lkrehi 1275 2 shock shock NN cord-335975-m6lkrehi 1275 3 and and CC cord-335975-m6lkrehi 1275 4 circulatory circulatory JJ cord-335975-m6lkrehi 1275 5 collapse collapse NN cord-335975-m6lkrehi 1275 6 occurred occur VBD cord-335975-m6lkrehi 1275 7 in in IN cord-335975-m6lkrehi 1275 8 3 3 CD cord-335975-m6lkrehi 1275 9 and and CC cord-335975-m6lkrehi 1275 10 5 5 CD cord-335975-m6lkrehi 1275 11 patients patient NNS cord-335975-m6lkrehi 1275 12 respectively respectively RB cord-335975-m6lkrehi 1275 13 . . . cord-335975-m6lkrehi 1276 1 MRI MRI NNP cord-335975-m6lkrehi 1276 2 and and CC cord-335975-m6lkrehi 1276 3 CT CT NNP cord-335975-m6lkrehi 1276 4 showed show VBD cord-335975-m6lkrehi 1276 5 lesions lesion NNS cord-335975-m6lkrehi 1276 6 that that WDT cord-335975-m6lkrehi 1276 7 may may MD cord-335975-m6lkrehi 1276 8 explain explain VB cord-335975-m6lkrehi 1276 9 the the DT cord-335975-m6lkrehi 1276 10 wake wake VB cord-335975-m6lkrehi 1276 11 - - HYPH cord-335975-m6lkrehi 1276 12 up up NN cord-335975-m6lkrehi 1276 13 delay delay NN cord-335975-m6lkrehi 1276 14 in in IN cord-335975-m6lkrehi 1276 15 6 6 CD cord-335975-m6lkrehi 1276 16 of of IN cord-335975-m6lkrehi 1276 17 11 11 CD cord-335975-m6lkrehi 1276 18 and and CC cord-335975-m6lkrehi 1276 19 4 4 CD cord-335975-m6lkrehi 1276 20 of of IN cord-335975-m6lkrehi 1276 21 16 16 CD cord-335975-m6lkrehi 1276 22 patients patient NNS cord-335975-m6lkrehi 1276 23 , , , cord-335975-m6lkrehi 1276 24 respectively respectively RB cord-335975-m6lkrehi 1276 25 . . . cord-335975-m6lkrehi 1277 1 Brain brain NN cord-335975-m6lkrehi 1277 2 anomalies anomaly NNS cord-335975-m6lkrehi 1277 3 included include VBD cord-335975-m6lkrehi 1277 4 anoxic anoxic JJ cord-335975-m6lkrehi 1277 5 lesions lesion NNS cord-335975-m6lkrehi 1277 6 ( ( -LRB- cord-335975-m6lkrehi 1277 7 n n NN cord-335975-m6lkrehi 1277 8 = = SYM cord-335975-m6lkrehi 1277 9 4 4 CD cord-335975-m6lkrehi 1277 10 ) ) -RRB- cord-335975-m6lkrehi 1277 11 with with IN cord-335975-m6lkrehi 1277 12 basal basal NN cord-335975-m6lkrehi 1277 13 ganglia ganglion NNS cord-335975-m6lkrehi 1277 14 involvement involvement NN cord-335975-m6lkrehi 1277 15 ( ( -LRB- cord-335975-m6lkrehi 1277 16 n n NN cord-335975-m6lkrehi 1277 17 = = SYM cord-335975-m6lkrehi 1277 18 3 3 CD cord-335975-m6lkrehi 1277 19 ) ) -RRB- cord-335975-m6lkrehi 1277 20 , , , cord-335975-m6lkrehi 1277 21 ischemic ischemic JJ cord-335975-m6lkrehi 1277 22 or or CC cord-335975-m6lkrehi 1277 23 hemorrhagic hemorrhagic JJ cord-335975-m6lkrehi 1277 24 strokes stroke NNS cord-335975-m6lkrehi 1277 25 ( ( -LRB- cord-335975-m6lkrehi 1277 26 n n NN cord-335975-m6lkrehi 1277 27 = = SYM cord-335975-m6lkrehi 1277 28 4 4 CD cord-335975-m6lkrehi 1277 29 ) ) -RRB- cord-335975-m6lkrehi 1277 30 , , , cord-335975-m6lkrehi 1277 31 hepatic hepatic JJ cord-335975-m6lkrehi 1277 32 encephalopathy encephalopathy NN cord-335975-m6lkrehi 1277 33 ( ( -LRB- cord-335975-m6lkrehi 1277 34 n n NN cord-335975-m6lkrehi 1277 35 = = SYM cord-335975-m6lkrehi 1277 36 1 1 CD cord-335975-m6lkrehi 1277 37 ) ) -RRB- cord-335975-m6lkrehi 1277 38 and and CC cord-335975-m6lkrehi 1277 39 herpetic herpetic NNP cord-335975-m6lkrehi 1277 40 encephalitis encephalitis RB cord-335975-m6lkrehi 1278 1 ( ( -LRB- cord-335975-m6lkrehi 1278 2 n n NN cord-335975-m6lkrehi 1278 3 = = SYM cord-335975-m6lkrehi 1278 4 1 1 CD cord-335975-m6lkrehi 1278 5 ) ) -RRB- cord-335975-m6lkrehi 1278 6 . . . cord-335975-m6lkrehi 1279 1 Conclusion conclusion NN cord-335975-m6lkrehi 1279 2 : : : cord-335975-m6lkrehi 1279 3 Brain brain NN cord-335975-m6lkrehi 1279 4 imaging imaging NN cord-335975-m6lkrehi 1279 5 techniques technique NNS cord-335975-m6lkrehi 1279 6 help help VBP cord-335975-m6lkrehi 1279 7 diagnosing diagnose VBG cord-335975-m6lkrehi 1279 8 causes cause NNS cord-335975-m6lkrehi 1279 9 of of IN cord-335975-m6lkrehi 1279 10 delayed delay VBN cord-335975-m6lkrehi 1279 11 wake wake NN cord-335975-m6lkrehi 1279 12 - - HYPH cord-335975-m6lkrehi 1279 13 up up NN cord-335975-m6lkrehi 1279 14 after after IN cord-335975-m6lkrehi 1279 15 induced induce VBN cord-335975-m6lkrehi 1279 16 coma coma NN cord-335975-m6lkrehi 1279 17 . . . cord-335975-m6lkrehi 1280 1 Anoxic Anoxic NNP cord-335975-m6lkrehi 1280 2 lesions lesion NNS cord-335975-m6lkrehi 1280 3 and and CC cord-335975-m6lkrehi 1280 4 strokes stroke NNS cord-335975-m6lkrehi 1280 5 are be VBP cord-335975-m6lkrehi 1280 6 mostly mostly RB cord-335975-m6lkrehi 1280 7 behind behind IN cord-335975-m6lkrehi 1280 8 this this DT cord-335975-m6lkrehi 1280 9 condition condition NN cord-335975-m6lkrehi 1280 10 . . . cord-335975-m6lkrehi 1281 1 MRI MRI NNP cord-335975-m6lkrehi 1281 2 is be VBZ cord-335975-m6lkrehi 1281 3 more more RBR cord-335975-m6lkrehi 1281 4 accurate accurate JJ cord-335975-m6lkrehi 1281 5 than than IN cord-335975-m6lkrehi 1281 6 CT CT NNP cord-335975-m6lkrehi 1281 7 . . . cord-335975-m6lkrehi 1282 1 Introduction introduction NN cord-335975-m6lkrehi 1282 2 : : : cord-335975-m6lkrehi 1283 1 Gastric gastric JJ cord-335975-m6lkrehi 1283 2 tubes tube NNS cord-335975-m6lkrehi 1283 3 are be VBP cord-335975-m6lkrehi 1283 4 common common JJ cord-335975-m6lkrehi 1283 5 in in IN cord-335975-m6lkrehi 1283 6 intensive intensive JJ cord-335975-m6lkrehi 1283 7 care care NN cord-335975-m6lkrehi 1283 8 units unit NNS cord-335975-m6lkrehi 1283 9 used use VBN cord-335975-m6lkrehi 1283 10 for for IN cord-335975-m6lkrehi 1283 11 enteral enteral JJ cord-335975-m6lkrehi 1283 12 feeding feeding NN cord-335975-m6lkrehi 1283 13 , , , cord-335975-m6lkrehi 1283 14 administration administration NN cord-335975-m6lkrehi 1283 15 of of IN cord-335975-m6lkrehi 1283 16 drugs drug NNS cord-335975-m6lkrehi 1283 17 or or CC cord-335975-m6lkrehi 1283 18 aspiration aspiration NN cord-335975-m6lkrehi 1283 19 of of IN cord-335975-m6lkrehi 1283 20 the the DT cord-335975-m6lkrehi 1283 21 digestive digestive JJ cord-335975-m6lkrehi 1283 22 tract tract NN cord-335975-m6lkrehi 1283 23 . . . cord-335975-m6lkrehi 1284 1 These these DT cord-335975-m6lkrehi 1284 2 tubes tube NNS cord-335975-m6lkrehi 1284 3 offer offer VBP cord-335975-m6lkrehi 1284 4 an an DT cord-335975-m6lkrehi 1284 5 excellent excellent JJ cord-335975-m6lkrehi 1284 6 tolerance tolerance NN cord-335975-m6lkrehi 1284 7 but but CC cord-335975-m6lkrehi 1284 8 malposition malposition NN cord-335975-m6lkrehi 1284 9 may may MD cord-335975-m6lkrehi 1284 10 have have VB cord-335975-m6lkrehi 1284 11 serious serious JJ cord-335975-m6lkrehi 1284 12 consequences consequence NNS cord-335975-m6lkrehi 1284 13 that that WDT cord-335975-m6lkrehi 1284 14 can can MD cord-335975-m6lkrehi 1284 15 lead lead VB cord-335975-m6lkrehi 1284 16 to to IN cord-335975-m6lkrehi 1284 17 patient patient NN cord-335975-m6lkrehi 1284 18 's 's POS cord-335975-m6lkrehi 1284 19 death death NN cord-335975-m6lkrehi 1284 20 . . . cord-335975-m6lkrehi 1285 1 The the DT cord-335975-m6lkrehi 1285 2 actualy actualy JJ cord-335975-m6lkrehi 1285 3 gold gold NN cord-335975-m6lkrehi 1285 4 method method NN cord-335975-m6lkrehi 1285 5 to to TO cord-335975-m6lkrehi 1285 6 confirm confirm VB cord-335975-m6lkrehi 1285 7 their -PRON- PRP$ cord-335975-m6lkrehi 1285 8 correct correct JJ cord-335975-m6lkrehi 1285 9 placement placement NN cord-335975-m6lkrehi 1285 10 is be VBZ cord-335975-m6lkrehi 1285 11 chest chest NN cord-335975-m6lkrehi 1285 12 X x NN cord-335975-m6lkrehi 1285 13 - - NN cord-335975-m6lkrehi 1285 14 ray ray NN cord-335975-m6lkrehi 1285 15 . . . cord-335975-m6lkrehi 1286 1 We -PRON- PRP cord-335975-m6lkrehi 1286 2 report report VBP cord-335975-m6lkrehi 1286 3 a a DT cord-335975-m6lkrehi 1286 4 study study NN cord-335975-m6lkrehi 1286 5 which which WDT cord-335975-m6lkrehi 1286 6 evaluate evaluate VBP cord-335975-m6lkrehi 1286 7 the the DT cord-335975-m6lkrehi 1286 8 performance performance NN cord-335975-m6lkrehi 1286 9 of of IN cord-335975-m6lkrehi 1286 10 gastric gastric JJ cord-335975-m6lkrehi 1286 11 ultrasonography ultrasonography NN cord-335975-m6lkrehi 1286 12 for for IN cord-335975-m6lkrehi 1286 13 the the DT cord-335975-m6lkrehi 1286 14 validation validation NN cord-335975-m6lkrehi 1286 15 of of IN cord-335975-m6lkrehi 1286 16 the the DT cord-335975-m6lkrehi 1286 17 good good JJ cord-335975-m6lkrehi 1286 18 positioning positioning NN cord-335975-m6lkrehi 1286 19 of of IN cord-335975-m6lkrehi 1286 20 the the DT cord-335975-m6lkrehi 1286 21 gastric gastric JJ cord-335975-m6lkrehi 1286 22 tube tube NN cord-335975-m6lkrehi 1286 23 . . . cord-335975-m6lkrehi 1287 1 We -PRON- PRP cord-335975-m6lkrehi 1287 2 carried carry VBD cord-335975-m6lkrehi 1287 3 out out RP cord-335975-m6lkrehi 1287 4 a a DT cord-335975-m6lkrehi 1287 5 prospective prospective JJ cord-335975-m6lkrehi 1287 6 , , , cord-335975-m6lkrehi 1287 7 monocentric monocentric JJ cord-335975-m6lkrehi 1287 8 study study NN cord-335975-m6lkrehi 1287 9 in in IN cord-335975-m6lkrehi 1287 10 a a DT cord-335975-m6lkrehi 1287 11 Medical Medical NNP cord-335975-m6lkrehi 1287 12 Intensive Intensive NNP cord-335975-m6lkrehi 1287 13 Care Care NNP cord-335975-m6lkrehi 1287 14 Units Units NNPS cord-335975-m6lkrehi 1287 15 . . . cord-335975-m6lkrehi 1288 1 For for IN cord-335975-m6lkrehi 1288 2 each each DT cord-335975-m6lkrehi 1288 3 included include VBN cord-335975-m6lkrehi 1288 4 patient patient NN cord-335975-m6lkrehi 1288 5 , , , cord-335975-m6lkrehi 1288 6 we -PRON- PRP cord-335975-m6lkrehi 1288 7 compared compare VBD cord-335975-m6lkrehi 1288 8 the the DT cord-335975-m6lkrehi 1288 9 results result NNS cord-335975-m6lkrehi 1288 10 of of IN cord-335975-m6lkrehi 1288 11 a a DT cord-335975-m6lkrehi 1288 12 gastric gastric JJ cord-335975-m6lkrehi 1288 13 ultrasonography ultrasonography NN cord-335975-m6lkrehi 1288 14 to to IN cord-335975-m6lkrehi 1288 15 the the DT cord-335975-m6lkrehi 1288 16 interpretation interpretation NN cord-335975-m6lkrehi 1288 17 of of IN cord-335975-m6lkrehi 1288 18 a a DT cord-335975-m6lkrehi 1288 19 chest chest NN cord-335975-m6lkrehi 1288 20 X x NN cord-335975-m6lkrehi 1288 21 - - NN cord-335975-m6lkrehi 1288 22 ray ray NN cord-335975-m6lkrehi 1288 23 . . . cord-335975-m6lkrehi 1289 1 Results result NNS cord-335975-m6lkrehi 1289 2 : : : cord-335975-m6lkrehi 1290 1 One one CD cord-335975-m6lkrehi 1290 2 hundred hundred CD cord-335975-m6lkrehi 1290 3 and and CC cord-335975-m6lkrehi 1290 4 thirteen thirteen CD cord-335975-m6lkrehi 1290 5 gastric gastric JJ cord-335975-m6lkrehi 1290 6 ultrasonographies ultrasonography NNS cord-335975-m6lkrehi 1290 7 were be VBD cord-335975-m6lkrehi 1290 8 performed perform VBN cord-335975-m6lkrehi 1290 9 from from IN cord-335975-m6lkrehi 1290 10 July July NNP cord-335975-m6lkrehi 1290 11 2016 2016 CD cord-335975-m6lkrehi 1290 12 to to IN cord-335975-m6lkrehi 1290 13 May May NNP cord-335975-m6lkrehi 1290 14 2017 2017 CD cord-335975-m6lkrehi 1290 15 . . . cord-335975-m6lkrehi 1291 1 In in IN cord-335975-m6lkrehi 1291 2 87 87 CD cord-335975-m6lkrehi 1291 3 cases case NNS cord-335975-m6lkrehi 1291 4 , , , cord-335975-m6lkrehi 1291 5 ultrasonography ultrasonography NN cord-335975-m6lkrehi 1291 6 concluded conclude VBD cord-335975-m6lkrehi 1291 7 that that IN cord-335975-m6lkrehi 1291 8 the the DT cord-335975-m6lkrehi 1291 9 gastric gastric JJ cord-335975-m6lkrehi 1291 10 tube tube NN cord-335975-m6lkrehi 1291 11 was be VBD cord-335975-m6lkrehi 1291 12 correctly correctly RB cord-335975-m6lkrehi 1291 13 positioned position VBN cord-335975-m6lkrehi 1291 14 , , , cord-335975-m6lkrehi 1291 15 confirmed confirm VBN cord-335975-m6lkrehi 1291 16 by by IN cord-335975-m6lkrehi 1291 17 chest chest NN cord-335975-m6lkrehi 1291 18 X x NN cord-335975-m6lkrehi 1291 19 - - NN cord-335975-m6lkrehi 1291 20 ray ray NN cord-335975-m6lkrehi 1291 21 . . . cord-335975-m6lkrehi 1292 1 In in IN cord-335975-m6lkrehi 1292 2 24 24 CD cord-335975-m6lkrehi 1292 3 cases case NNS cord-335975-m6lkrehi 1292 4 , , , cord-335975-m6lkrehi 1292 5 ultrasonography ultrasonography NN cord-335975-m6lkrehi 1292 6 did do VBD cord-335975-m6lkrehi 1292 7 not not RB cord-335975-m6lkrehi 1292 8 visualize visualize VB cord-335975-m6lkrehi 1292 9 the the DT cord-335975-m6lkrehi 1292 10 tube tube NN cord-335975-m6lkrehi 1292 11 in in IN cord-335975-m6lkrehi 1292 12 gastric gastric JJ cord-335975-m6lkrehi 1292 13 area area NN cord-335975-m6lkrehi 1292 14 . . . cord-335975-m6lkrehi 1293 1 Among among IN cord-335975-m6lkrehi 1293 2 these these DT cord-335975-m6lkrehi 1293 3 24 24 CD cord-335975-m6lkrehi 1293 4 cases case NNS cord-335975-m6lkrehi 1293 5 , , , cord-335975-m6lkrehi 1293 6 only only RB cord-335975-m6lkrehi 1293 7 4 4 CD cord-335975-m6lkrehi 1293 8 malpositions malposition NNS cord-335975-m6lkrehi 1293 9 were be VBD cord-335975-m6lkrehi 1293 10 detected detect VBN cord-335975-m6lkrehi 1293 11 by by IN cord-335975-m6lkrehi 1293 12 the the DT cord-335975-m6lkrehi 1293 13 chest chest NN cord-335975-m6lkrehi 1293 14 X x NN cord-335975-m6lkrehi 1293 15 - - NN cord-335975-m6lkrehi 1293 16 ray ray NN cord-335975-m6lkrehi 1293 17 . . . cord-335975-m6lkrehi 1294 1 The the DT cord-335975-m6lkrehi 1294 2 sensitivity sensitivity NN cord-335975-m6lkrehi 1294 3 and and CC cord-335975-m6lkrehi 1294 4 specificity specificity NN cord-335975-m6lkrehi 1294 5 of of IN cord-335975-m6lkrehi 1294 6 gastric gastric JJ cord-335975-m6lkrehi 1294 7 ultrasonography ultrasonography NN cord-335975-m6lkrehi 1294 8 were be VBD cord-335975-m6lkrehi 1294 9 0.81 0.81 CD cord-335975-m6lkrehi 1294 10 [ [ -LRB- cord-335975-m6lkrehi 1294 11 0.72 0.72 CD cord-335975-m6lkrehi 1294 12 + + SYM cord-335975-m6lkrehi 1294 13 0.87 0.87 CD cord-335975-m6lkrehi 1294 14 ] ] -RRB- cord-335975-m6lkrehi 1294 15 and and CC cord-335975-m6lkrehi 1294 16 1 1 CD cord-335975-m6lkrehi 1294 17 [ [ -LRB- cord-335975-m6lkrehi 1294 18 0.51 0.51 CD cord-335975-m6lkrehi 1294 19 + + SYM cord-335975-m6lkrehi 1294 20 1 1 CD cord-335975-m6lkrehi 1294 21 ] ] -RRB- cord-335975-m6lkrehi 1294 22 . . . cord-335975-m6lkrehi 1295 1 Positive positive JJ cord-335975-m6lkrehi 1295 2 and and CC cord-335975-m6lkrehi 1295 3 negative negative JJ cord-335975-m6lkrehi 1295 4 predictive predictive JJ cord-335975-m6lkrehi 1295 5 values value NNS cord-335975-m6lkrehi 1295 6 were be VBD cord-335975-m6lkrehi 1295 7 1 1 CD cord-335975-m6lkrehi 1295 8 and and CC cord-335975-m6lkrehi 1295 9 0.17 0.17 CD cord-335975-m6lkrehi 1295 10 , , , cord-335975-m6lkrehi 1295 11 respectively respectively RB cord-335975-m6lkrehi 1295 12 . . . cord-335975-m6lkrehi 1296 1 The the DT cord-335975-m6lkrehi 1296 2 ultrasonography ultrasonography NN cord-335975-m6lkrehi 1296 3 was be VBD cord-335975-m6lkrehi 1296 4 performed perform VBN cord-335975-m6lkrehi 1296 5 54 54 CD cord-335975-m6lkrehi 1296 6 min min NN cord-335975-m6lkrehi 1296 7 [ [ -LRB- cord-335975-m6lkrehi 1296 8 50.3 50.3 CD cord-335975-m6lkrehi 1296 9 + + SYM cord-335975-m6lkrehi 1296 10 57.6 57.6 CD cord-335975-m6lkrehi 1296 11 ] ] -RRB- cord-335975-m6lkrehi 1296 12 after after IN cord-335975-m6lkrehi 1296 13 the the DT cord-335975-m6lkrehi 1296 14 gastric gastric JJ cord-335975-m6lkrehi 1296 15 tube tube NN cord-335975-m6lkrehi 1296 16 placement placement NN cord-335975-m6lkrehi 1296 17 while while IN cord-335975-m6lkrehi 1296 18 the the DT cord-335975-m6lkrehi 1296 19 chest chest NN cord-335975-m6lkrehi 1296 20 X x NN cord-335975-m6lkrehi 1296 21 - - NN cord-335975-m6lkrehi 1296 22 ray ray NN cord-335975-m6lkrehi 1296 23 was be VBD cord-335975-m6lkrehi 1296 24 interpreted interpret VBN cord-335975-m6lkrehi 1296 25 211 211 CD cord-335975-m6lkrehi 1296 26 min min NN cord-335975-m6lkrehi 1296 27 [ [ -LRB- cord-335975-m6lkrehi 1296 28 170.9 170.9 CD cord-335975-m6lkrehi 1296 29 + + SYM cord-335975-m6lkrehi 1296 30 251.7 251.7 CD cord-335975-m6lkrehi 1296 31 ] ] -RRB- cord-335975-m6lkrehi 1296 32 after after IN cord-335975-m6lkrehi 1296 33 this this DT cord-335975-m6lkrehi 1296 34 same same JJ cord-335975-m6lkrehi 1296 35 placement placement NN cord-335975-m6lkrehi 1296 36 ( ( -LRB- cord-335975-m6lkrehi 1296 37 p p NN cord-335975-m6lkrehi 1296 38 < < XX cord-335975-m6lkrehi 1296 39 0.0001 0.0001 CD cord-335975-m6lkrehi 1296 40 ) ) -RRB- cord-335975-m6lkrehi 1296 41 . . . cord-335975-m6lkrehi 1297 1 Our -PRON- PRP$ cord-335975-m6lkrehi 1297 2 results result NNS cord-335975-m6lkrehi 1297 3 suggest suggest VBP cord-335975-m6lkrehi 1297 4 a a DT cord-335975-m6lkrehi 1297 5 good good JJ cord-335975-m6lkrehi 1297 6 performance performance NN cord-335975-m6lkrehi 1297 7 of of IN cord-335975-m6lkrehi 1297 8 gastric gastric JJ cord-335975-m6lkrehi 1297 9 ultrasonography ultrasonography NN cord-335975-m6lkrehi 1297 10 to to TO cord-335975-m6lkrehi 1297 11 check check VB cord-335975-m6lkrehi 1297 12 the the DT cord-335975-m6lkrehi 1297 13 positioning positioning NN cord-335975-m6lkrehi 1297 14 of of IN cord-335975-m6lkrehi 1297 15 the the DT cord-335975-m6lkrehi 1297 16 gastric gastric JJ cord-335975-m6lkrehi 1297 17 tube tube NN cord-335975-m6lkrehi 1297 18 . . . cord-335975-m6lkrehi 1298 1 This this DT cord-335975-m6lkrehi 1298 2 result result NN cord-335975-m6lkrehi 1298 3 must must MD cord-335975-m6lkrehi 1298 4 be be VB cord-335975-m6lkrehi 1298 5 interpreted interpret VBN cord-335975-m6lkrehi 1298 6 with with IN cord-335975-m6lkrehi 1298 7 caution caution NN cord-335975-m6lkrehi 1298 8 because because IN cord-335975-m6lkrehi 1298 9 of of IN cord-335975-m6lkrehi 1298 10 a a DT cord-335975-m6lkrehi 1298 11 low low JJ cord-335975-m6lkrehi 1298 12 power power NN cord-335975-m6lkrehi 1298 13 of of IN cord-335975-m6lkrehi 1298 14 the the DT cord-335975-m6lkrehi 1298 15 study study NN cord-335975-m6lkrehi 1298 16 . . . cord-335975-m6lkrehi 1299 1 We -PRON- PRP cord-335975-m6lkrehi 1299 2 planned plan VBD cord-335975-m6lkrehi 1299 3 a a DT cord-335975-m6lkrehi 1299 4 multi multi JJ cord-335975-m6lkrehi 1299 5 - - JJ cord-335975-m6lkrehi 1299 6 center center JJ cord-335975-m6lkrehi 1299 7 study study NN cord-335975-m6lkrehi 1299 8 to to TO cord-335975-m6lkrehi 1299 9 confirm confirm VB cord-335975-m6lkrehi 1299 10 our -PRON- PRP$ cord-335975-m6lkrehi 1299 11 results result NNS cord-335975-m6lkrehi 1299 12 . . . cord-335975-m6lkrehi 1300 1 Giabicani Giabicani NNP cord-335975-m6lkrehi 1300 2 Mikhael Mikhael NNP cord-335975-m6lkrehi 1300 3 Introduction introduction NN cord-335975-m6lkrehi 1300 4 : : : cord-335975-m6lkrehi 1300 5 Prognosis prognosis NN cord-335975-m6lkrehi 1300 6 of of IN cord-335975-m6lkrehi 1300 7 cirrhotic cirrhotic JJ cord-335975-m6lkrehi 1300 8 patients patient NNS cord-335975-m6lkrehi 1300 9 hospitalized hospitalize VBN cord-335975-m6lkrehi 1300 10 in in IN cord-335975-m6lkrehi 1300 11 intensive intensive JJ cord-335975-m6lkrehi 1300 12 care care NN cord-335975-m6lkrehi 1300 13 unit unit NN cord-335975-m6lkrehi 1300 14 ( ( -LRB- cord-335975-m6lkrehi 1300 15 ICU ICU NNP cord-335975-m6lkrehi 1300 16 ) ) -RRB- cord-335975-m6lkrehi 1300 17 remains remain VBZ cord-335975-m6lkrehi 1300 18 poor poor JJ cord-335975-m6lkrehi 1300 19 . . . cord-335975-m6lkrehi 1301 1 In in IN cord-335975-m6lkrehi 1301 2 many many JJ cord-335975-m6lkrehi 1301 3 ICUs icu NNS cord-335975-m6lkrehi 1301 4 , , , cord-335975-m6lkrehi 1301 5 cirrhotic cirrhotic JJ cord-335975-m6lkrehi 1301 6 patients patient NNS cord-335975-m6lkrehi 1301 7 are be VBP cord-335975-m6lkrehi 1301 8 widely widely RB cord-335975-m6lkrehi 1301 9 admitted admit VBN cord-335975-m6lkrehi 1301 10 and and CC cord-335975-m6lkrehi 1301 11 revalued revalue VBN cord-335975-m6lkrehi 1301 12 after after IN cord-335975-m6lkrehi 1301 13 receiving receive VBG cord-335975-m6lkrehi 1301 14 optimal optimal JJ cord-335975-m6lkrehi 1301 15 treatments treatment NNS cord-335975-m6lkrehi 1301 16 . . . cord-335975-m6lkrehi 1302 1 Little little JJ cord-335975-m6lkrehi 1302 2 is be VBZ cord-335975-m6lkrehi 1302 3 known know VBN cord-335975-m6lkrehi 1302 4 about about IN cord-335975-m6lkrehi 1302 5 risk risk NN cord-335975-m6lkrehi 1302 6 factors factor NNS cord-335975-m6lkrehi 1302 7 involved involve VBN cord-335975-m6lkrehi 1302 8 in in IN cord-335975-m6lkrehi 1302 9 the the DT cord-335975-m6lkrehi 1302 10 evaluation evaluation NN cord-335975-m6lkrehi 1302 11 of of IN cord-335975-m6lkrehi 1302 12 the the DT cord-335975-m6lkrehi 1302 13 prognosis prognosis NN cord-335975-m6lkrehi 1302 14 at at IN cord-335975-m6lkrehi 1302 15 day day NN cord-335975-m6lkrehi 1302 16 3 3 CD cord-335975-m6lkrehi 1302 17 , , , cord-335975-m6lkrehi 1302 18 except except IN cord-335975-m6lkrehi 1302 19 the the DT cord-335975-m6lkrehi 1302 20 persistence persistence NN cord-335975-m6lkrehi 1302 21 of of IN cord-335975-m6lkrehi 1302 22 organ organ NN cord-335975-m6lkrehi 1302 23 failure failure NN cord-335975-m6lkrehi 1302 24 . . . cord-335975-m6lkrehi 1303 1 This this DT cord-335975-m6lkrehi 1303 2 susceptibility susceptibility NN cord-335975-m6lkrehi 1303 3 to to IN cord-335975-m6lkrehi 1303 4 organ organ NN cord-335975-m6lkrehi 1303 5 failure failure NN cord-335975-m6lkrehi 1303 6 would would MD cord-335975-m6lkrehi 1303 7 be be VB cord-335975-m6lkrehi 1303 8 related relate VBN cord-335975-m6lkrehi 1303 9 to to IN cord-335975-m6lkrehi 1303 10 an an DT cord-335975-m6lkrehi 1303 11 alteration alteration NN cord-335975-m6lkrehi 1303 12 of of IN cord-335975-m6lkrehi 1303 13 the the DT cord-335975-m6lkrehi 1303 14 regulation regulation NN cord-335975-m6lkrehi 1303 15 mechanisms mechanism NNS cord-335975-m6lkrehi 1303 16 of of IN cord-335975-m6lkrehi 1303 17 the the DT cord-335975-m6lkrehi 1303 18 systemic systemic JJ cord-335975-m6lkrehi 1303 19 inflammatory inflammatory JJ cord-335975-m6lkrehi 1303 20 response response NN cord-335975-m6lkrehi 1303 21 . . . cord-335975-m6lkrehi 1304 1 The the DT cord-335975-m6lkrehi 1304 2 blood blood NN cord-335975-m6lkrehi 1304 3 neutrophil neutrophil NN cord-335975-m6lkrehi 1304 4 - - HYPH cord-335975-m6lkrehi 1304 5 to to IN cord-335975-m6lkrehi 1304 6 - - HYPH cord-335975-m6lkrehi 1304 7 lymphocyte lymphocyte NN cord-335975-m6lkrehi 1304 8 ratio ratio NN cord-335975-m6lkrehi 1304 9 ( ( -LRB- cord-335975-m6lkrehi 1304 10 NLR NLR NNP cord-335975-m6lkrehi 1304 11 ) ) -RRB- cord-335975-m6lkrehi 1304 12 is be VBZ cord-335975-m6lkrehi 1304 13 an an DT cord-335975-m6lkrehi 1304 14 inflammation inflammation NN cord-335975-m6lkrehi 1304 15 biomarker biomarker NN cord-335975-m6lkrehi 1304 16 reported report VBN cord-335975-m6lkrehi 1304 17 to to TO cord-335975-m6lkrehi 1304 18 predict predict VB cord-335975-m6lkrehi 1304 19 clinical clinical JJ cord-335975-m6lkrehi 1304 20 outcome outcome NN cord-335975-m6lkrehi 1304 21 in in IN cord-335975-m6lkrehi 1304 22 unselected unselected JJ cord-335975-m6lkrehi 1304 23 critically critically RB cord-335975-m6lkrehi 1304 24 ill ill JJ cord-335975-m6lkrehi 1304 25 patients patient NNS cord-335975-m6lkrehi 1304 26 and and CC cord-335975-m6lkrehi 1304 27 in in IN cord-335975-m6lkrehi 1304 28 patients patient NNS cord-335975-m6lkrehi 1304 29 with with IN cord-335975-m6lkrehi 1304 30 stable stable JJ cord-335975-m6lkrehi 1304 31 liver liver NN cord-335975-m6lkrehi 1304 32 cirrhosis cirrhosis NN cord-335975-m6lkrehi 1304 33 , , , cord-335975-m6lkrehi 1304 34 but but CC cord-335975-m6lkrehi 1304 35 has have VBZ cord-335975-m6lkrehi 1304 36 never never RB cord-335975-m6lkrehi 1304 37 been be VBN cord-335975-m6lkrehi 1304 38 studied study VBN cord-335975-m6lkrehi 1304 39 in in IN cord-335975-m6lkrehi 1304 40 critically critically RB cord-335975-m6lkrehi 1304 41 ill ill JJ cord-335975-m6lkrehi 1304 42 cirrhotic cirrhotic JJ cord-335975-m6lkrehi 1304 43 patients patient NNS cord-335975-m6lkrehi 1304 44 . . . cord-335975-m6lkrehi 1305 1 The the DT cord-335975-m6lkrehi 1305 2 aim aim NN cord-335975-m6lkrehi 1305 3 of of IN cord-335975-m6lkrehi 1305 4 this this DT cord-335975-m6lkrehi 1305 5 study study NN cord-335975-m6lkrehi 1305 6 was be VBD cord-335975-m6lkrehi 1305 7 to to TO cord-335975-m6lkrehi 1305 8 evaluate evaluate VB cord-335975-m6lkrehi 1305 9 the the DT cord-335975-m6lkrehi 1305 10 blood blood NN cord-335975-m6lkrehi 1305 11 NLR NLR NNP cord-335975-m6lkrehi 1305 12 as as IN cord-335975-m6lkrehi 1305 13 parameter parameter NN cord-335975-m6lkrehi 1305 14 to to TO cord-335975-m6lkrehi 1305 15 predict predict VB cord-335975-m6lkrehi 1305 16 mortality mortality NN cord-335975-m6lkrehi 1305 17 of of IN cord-335975-m6lkrehi 1305 18 cirrhotic cirrhotic JJ cord-335975-m6lkrehi 1305 19 patients patient NNS cord-335975-m6lkrehi 1305 20 hospitalized hospitalize VBN cord-335975-m6lkrehi 1305 21 > > XX cord-335975-m6lkrehi 1305 22 3 3 CD cord-335975-m6lkrehi 1305 23 days day NNS cord-335975-m6lkrehi 1305 24 in in IN cord-335975-m6lkrehi 1305 25 ICU ICU NNP cord-335975-m6lkrehi 1305 26 . . . cord-335975-m6lkrehi 1306 1 Retrospective retrospective JJ cord-335975-m6lkrehi 1306 2 monocentric monocentric JJ cord-335975-m6lkrehi 1306 3 study study NN cord-335975-m6lkrehi 1306 4 including include VBG cord-335975-m6lkrehi 1306 5 consecutively consecutively RB cord-335975-m6lkrehi 1306 6 cirrhotic cirrhotic JJ cord-335975-m6lkrehi 1306 7 patients patient NNS cord-335975-m6lkrehi 1306 8 hospitalized hospitalize VBN cord-335975-m6lkrehi 1306 9 in in IN cord-335975-m6lkrehi 1306 10 a a DT cord-335975-m6lkrehi 1306 11 medical medical JJ cord-335975-m6lkrehi 1306 12 ICU ICU NNP cord-335975-m6lkrehi 1306 13 from from IN cord-335975-m6lkrehi 1306 14 2010 2010 CD cord-335975-m6lkrehi 1306 15 to to IN cord-335975-m6lkrehi 1306 16 2016 2016 CD cord-335975-m6lkrehi 1306 17 . . . cord-335975-m6lkrehi 1307 1 For for IN cord-335975-m6lkrehi 1307 2 each each DT cord-335975-m6lkrehi 1307 3 patient patient JJ cord-335975-m6lkrehi 1307 4 , , , cord-335975-m6lkrehi 1307 5 clinical clinical JJ cord-335975-m6lkrehi 1307 6 and and CC cord-335975-m6lkrehi 1307 7 biological biological JJ cord-335975-m6lkrehi 1307 8 data datum NNS cord-335975-m6lkrehi 1307 9 at at IN cord-335975-m6lkrehi 1307 10 admission admission NN cord-335975-m6lkrehi 1307 11 and and CC cord-335975-m6lkrehi 1307 12 day day NN cord-335975-m6lkrehi 1307 13 3 3 CD cord-335975-m6lkrehi 1307 14 were be VBD cord-335975-m6lkrehi 1307 15 collected collect VBN cord-335975-m6lkrehi 1307 16 . . . cord-335975-m6lkrehi 1308 1 NLR NLR NNP cord-335975-m6lkrehi 1308 2 at at IN cord-335975-m6lkrehi 1308 3 admission admission NN cord-335975-m6lkrehi 1308 4 ( ( -LRB- cord-335975-m6lkrehi 1308 5 " " `` cord-335975-m6lkrehi 1308 6 NLRD0 NLRD0 NNS cord-335975-m6lkrehi 1308 7 " " '' cord-335975-m6lkrehi 1308 8 ) ) -RRB- cord-335975-m6lkrehi 1308 9 , , , cord-335975-m6lkrehi 1308 10 at at IN cord-335975-m6lkrehi 1308 11 day day NN cord-335975-m6lkrehi 1308 12 3 3 CD cord-335975-m6lkrehi 1308 13 ( ( -LRB- cord-335975-m6lkrehi 1308 14 " " `` cord-335975-m6lkrehi 1308 15 NLRD3 NLRD3 NNP cord-335975-m6lkrehi 1308 16 " " '' cord-335975-m6lkrehi 1308 17 ) ) -RRB- cord-335975-m6lkrehi 1308 18 and and CC cord-335975-m6lkrehi 1308 19 its -PRON- PRP$ cord-335975-m6lkrehi 1308 20 variation variation NN cord-335975-m6lkrehi 1308 21 between between IN cord-335975-m6lkrehi 1308 22 admission admission NN cord-335975-m6lkrehi 1308 23 and and CC cord-335975-m6lkrehi 1308 24 D3 D3 NNP cord-335975-m6lkrehi 1308 25 ( ( -LRB- cord-335975-m6lkrehi 1308 26 " " `` cord-335975-m6lkrehi 1308 27 delta delta NNP cord-335975-m6lkrehi 1308 28 NLR NLR NNP cord-335975-m6lkrehi 1308 29 " " '' cord-335975-m6lkrehi 1308 30 ) ) -RRB- cord-335975-m6lkrehi 1308 31 were be VBD cord-335975-m6lkrehi 1308 32 calculated calculate VBN cord-335975-m6lkrehi 1308 33 . . . cord-335975-m6lkrehi 1309 1 Statistical statistical JJ cord-335975-m6lkrehi 1309 2 analysis analysis NN cord-335975-m6lkrehi 1309 3 used use VBD cord-335975-m6lkrehi 1309 4 appropriate appropriate JJ cord-335975-m6lkrehi 1309 5 non non AFX cord-335975-m6lkrehi 1309 6 parametric parametric JJ cord-335975-m6lkrehi 1309 7 tests test NNS cord-335975-m6lkrehi 1309 8 and and CC cord-335975-m6lkrehi 1309 9 Cox Cox NNP cord-335975-m6lkrehi 1309 10 regression regression NN cord-335975-m6lkrehi 1309 11 for for IN cord-335975-m6lkrehi 1309 12 survival survival NN cord-335975-m6lkrehi 1309 13 analysis analysis NN cord-335975-m6lkrehi 1309 14 . . . cord-335975-m6lkrehi 1310 1 The the DT cord-335975-m6lkrehi 1310 2 ability ability NN cord-335975-m6lkrehi 1310 3 of of IN cord-335975-m6lkrehi 1310 4 the the DT cord-335975-m6lkrehi 1310 5 variables variable NNS cord-335975-m6lkrehi 1310 6 to to TO cord-335975-m6lkrehi 1310 7 discriminate discriminate VB cord-335975-m6lkrehi 1310 8 survivors survivor NNS cord-335975-m6lkrehi 1310 9 from from IN cord-335975-m6lkrehi 1310 10 non non NNS cord-335975-m6lkrehi 1310 11 - - NNS cord-335975-m6lkrehi 1310 12 survivors survivor NNS cord-335975-m6lkrehi 1310 13 was be VBD cord-335975-m6lkrehi 1310 14 determined determine VBN cord-335975-m6lkrehi 1310 15 using use VBG cord-335975-m6lkrehi 1310 16 ROC ROC NNP cord-335975-m6lkrehi 1310 17 curves curve NNS cord-335975-m6lkrehi 1310 18 and and CC cord-335975-m6lkrehi 1310 19 a a DT cord-335975-m6lkrehi 1310 20 Net Net NNP cord-335975-m6lkrehi 1310 21 Reclassification Reclassification NNP cord-335975-m6lkrehi 1310 22 Index Index NNP cord-335975-m6lkrehi 1310 23 ( ( -LRB- cord-335975-m6lkrehi 1310 24 NRI NRI NNP cord-335975-m6lkrehi 1310 25 ) ) -RRB- cord-335975-m6lkrehi 1310 26 . . . cord-335975-m6lkrehi 1311 1 Results result NNS cord-335975-m6lkrehi 1311 2 : : : cord-335975-m6lkrehi 1311 3 140 140 CD cord-335975-m6lkrehi 1311 4 patients patient NNS cord-335975-m6lkrehi 1311 5 ( ( -LRB- cord-335975-m6lkrehi 1311 6 median median JJ cord-335975-m6lkrehi 1311 7 Child Child NNP cord-335975-m6lkrehi 1311 8 - - HYPH cord-335975-m6lkrehi 1311 9 Pugh Pugh NNP cord-335975-m6lkrehi 1311 10 score score NN cord-335975-m6lkrehi 1311 11 = = SYM cord-335975-m6lkrehi 1311 12 9 9 CD cord-335975-m6lkrehi 1311 13 [ [ -LRB- cord-335975-m6lkrehi 1311 14 7 7 CD cord-335975-m6lkrehi 1311 15 - - SYM cord-335975-m6lkrehi 1311 16 11 11 CD cord-335975-m6lkrehi 1311 17 ] ] -RRB- cord-335975-m6lkrehi 1311 18 , , , cord-335975-m6lkrehi 1311 19 median median JJ cord-335975-m6lkrehi 1311 20 MELD meld VB cord-335975-m6lkrehi 1311 21 score score NN cord-335975-m6lkrehi 1311 22 = = SYM cord-335975-m6lkrehi 1311 23 25 25 CD cord-335975-m6lkrehi 1311 24 [ [ -LRB- cord-335975-m6lkrehi 1311 25 19 19 CD cord-335975-m6lkrehi 1311 26 - - SYM cord-335975-m6lkrehi 1311 27 30 30 CD cord-335975-m6lkrehi 1311 28 ] ] -RRB- cord-335975-m6lkrehi 1311 29 ) ) -RRB- cord-335975-m6lkrehi 1311 30 were be VBD cord-335975-m6lkrehi 1311 31 hospitalized hospitalize VBN cord-335975-m6lkrehi 1311 32 more more JJR cord-335975-m6lkrehi 1311 33 than than IN cord-335975-m6lkrehi 1311 34 3 3 CD cord-335975-m6lkrehi 1311 35 days day NNS cord-335975-m6lkrehi 1311 36 in in IN cord-335975-m6lkrehi 1311 37 ICU ICU NNP cord-335975-m6lkrehi 1311 38 . . . cord-335975-m6lkrehi 1312 1 The the DT cord-335975-m6lkrehi 1312 2 major major JJ cord-335975-m6lkrehi 1312 3 causes cause NNS cord-335975-m6lkrehi 1312 4 for for IN cord-335975-m6lkrehi 1312 5 ICU ICU NNP cord-335975-m6lkrehi 1312 6 admission admission NN cord-335975-m6lkrehi 1312 7 were be VBD cord-335975-m6lkrehi 1312 8 sepsis sepsis NN cord-335975-m6lkrehi 1312 9 ( ( -LRB- cord-335975-m6lkrehi 1312 10 56.4 56.4 CD cord-335975-m6lkrehi 1312 11 % % NN cord-335975-m6lkrehi 1312 12 ) ) -RRB- cord-335975-m6lkrehi 1312 13 , , , cord-335975-m6lkrehi 1312 14 gastrointestinal gastrointestinal JJ cord-335975-m6lkrehi 1312 15 bleeding bleeding NN cord-335975-m6lkrehi 1312 16 ( ( -LRB- cord-335975-m6lkrehi 1312 17 15 15 CD cord-335975-m6lkrehi 1312 18 % % NN cord-335975-m6lkrehi 1312 19 ) ) -RRB- cord-335975-m6lkrehi 1312 20 or or CC cord-335975-m6lkrehi 1312 21 respiratory respiratory JJ cord-335975-m6lkrehi 1312 22 failure failure NN cord-335975-m6lkrehi 1312 23 ( ( -LRB- cord-335975-m6lkrehi 1312 24 6.4 6.4 CD cord-335975-m6lkrehi 1312 25 % % NN cord-335975-m6lkrehi 1312 26 ) ) -RRB- cord-335975-m6lkrehi 1312 27 . . . cord-335975-m6lkrehi 1313 1 Patients patient NNS cord-335975-m6lkrehi 1313 2 were be VBD cord-335975-m6lkrehi 1313 3 followed follow VBN cord-335975-m6lkrehi 1313 4 up up RP cord-335975-m6lkrehi 1313 5 for for IN cord-335975-m6lkrehi 1313 6 38.5d 38.5d CD cord-335975-m6lkrehi 1313 7 . . . cord-335975-m6lkrehi 1314 1 74 74 CD cord-335975-m6lkrehi 1314 2 ( ( -LRB- cord-335975-m6lkrehi 1314 3 53 53 CD cord-335975-m6lkrehi 1314 4 % % NN cord-335975-m6lkrehi 1314 5 ) ) -RRB- cord-335975-m6lkrehi 1314 6 patients patient NNS cord-335975-m6lkrehi 1314 7 died-38 died-38 NNP cord-335975-m6lkrehi 1314 8 ( ( -LRB- cord-335975-m6lkrehi 1314 9 27 27 CD cord-335975-m6lkrehi 1314 10 % % NN cord-335975-m6lkrehi 1314 11 ) ) -RRB- cord-335975-m6lkrehi 1314 12 in in IN cord-335975-m6lkrehi 1314 13 ICU ICU NNP cord-335975-m6lkrehi 1314 14 , , , cord-335975-m6lkrehi 1314 15 21 21 CD cord-335975-m6lkrehi 1314 16 ( ( -LRB- cord-335975-m6lkrehi 1314 17 15 15 CD cord-335975-m6lkrehi 1314 18 % % NN cord-335975-m6lkrehi 1314 19 ) ) -RRB- cord-335975-m6lkrehi 1314 20 after after IN cord-335975-m6lkrehi 1314 21 ICU ICU NNP cord-335975-m6lkrehi 1314 22 discharge discharge NN cord-335975-m6lkrehi 1314 23 and and CC cord-335975-m6lkrehi 1314 24 15 15 CD cord-335975-m6lkrehi 1314 25 ( ( -LRB- cord-335975-m6lkrehi 1314 26 11 11 CD cord-335975-m6lkrehi 1314 27 % % NN cord-335975-m6lkrehi 1314 28 ) ) -RRB- cord-335975-m6lkrehi 1315 1 after after IN cord-335975-m6lkrehi 1315 2 hospital hospital NN cord-335975-m6lkrehi 1315 3 discharge discharge NN cord-335975-m6lkrehi 1315 4 . . . cord-335975-m6lkrehi 1316 1 In in IN cord-335975-m6lkrehi 1316 2 univariate univariate JJ cord-335975-m6lkrehi 1316 3 analysis analysis NN cord-335975-m6lkrehi 1316 4 , , , cord-335975-m6lkrehi 1316 5 factors factor NNS cord-335975-m6lkrehi 1316 6 significantly significantly RB cord-335975-m6lkrehi 1316 7 associated associate VBN cord-335975-m6lkrehi 1316 8 with with IN cord-335975-m6lkrehi 1316 9 mortality mortality NN cord-335975-m6lkrehi 1316 10 wereat wereat NNP cord-335975-m6lkrehi 1316 11 D3 D3 NNP cord-335975-m6lkrehi 1316 12 , , , cord-335975-m6lkrehi 1316 13 NLR NLR NNP cord-335975-m6lkrehi 1316 14 , , , cord-335975-m6lkrehi 1316 15 MELD meld VB cord-335975-m6lkrehi 1316 16 and and CC cord-335975-m6lkrehi 1316 17 SOFA sofa NN cord-335975-m6lkrehi 1316 18 scores score NNS cord-335975-m6lkrehi 1316 19 + + CC cord-335975-m6lkrehi 1316 20 and and CC cord-335975-m6lkrehi 1316 21 between between IN cord-335975-m6lkrehi 1316 22 D0 d0 NN cord-335975-m6lkrehi 1316 23 and and CC cord-335975-m6lkrehi 1316 24 D3-delta D3-delta NNP cord-335975-m6lkrehi 1316 25 NLR NLR NNP cord-335975-m6lkrehi 1316 26 , , , cord-335975-m6lkrehi 1316 27 delta delta NN cord-335975-m6lkrehi 1316 28 SOFA sofa NN cord-335975-m6lkrehi 1316 29 and and CC cord-335975-m6lkrehi 1316 30 delta delta NN cord-335975-m6lkrehi 1316 31 MELD meld VB cord-335975-m6lkrehi 1316 32 . . . cord-335975-m6lkrehi 1317 1 Predictors predictor NNS cord-335975-m6lkrehi 1317 2 of of IN cord-335975-m6lkrehi 1317 3 death death NN cord-335975-m6lkrehi 1317 4 in in IN cord-335975-m6lkrehi 1317 5 multivariate multivariate JJ cord-335975-m6lkrehi 1317 6 analysis analysis NN cord-335975-m6lkrehi 1317 7 are be VBP cord-335975-m6lkrehi 1317 8 shown show VBN cord-335975-m6lkrehi 1317 9 in in IN cord-335975-m6lkrehi 1317 10 Table Table NNP cord-335975-m6lkrehi 1317 11 1 1 CD cord-335975-m6lkrehi 1317 12 . . . cord-335975-m6lkrehi 1318 1 Area area NN cord-335975-m6lkrehi 1318 2 under under IN cord-335975-m6lkrehi 1318 3 delta delta NN cord-335975-m6lkrehi 1318 4 NLR NLR NNP cord-335975-m6lkrehi 1318 5 ROC ROC NNP cord-335975-m6lkrehi 1318 6 curve curve NN cord-335975-m6lkrehi 1318 7 was be VBD cord-335975-m6lkrehi 1318 8 0.74 0.74 CD cord-335975-m6lkrehi 1318 9 ( ( -LRB- cord-335975-m6lkrehi 1318 10 CI ci NN cord-335975-m6lkrehi 1318 11 = = SYM cord-335975-m6lkrehi 1318 12 0.69 0.69 CD cord-335975-m6lkrehi 1318 13 - - SYM cord-335975-m6lkrehi 1318 14 0.79 0.79 CD cord-335975-m6lkrehi 1318 15 ) ) -RRB- cord-335975-m6lkrehi 1318 16 . . . cord-335975-m6lkrehi 1319 1 NRI NRI NNP cord-335975-m6lkrehi 1319 2 revealed reveal VBD cord-335975-m6lkrehi 1319 3 that that IN cord-335975-m6lkrehi 1319 4 delta delta NN cord-335975-m6lkrehi 1319 5 NLR NLR NNP cord-335975-m6lkrehi 1319 6 was be VBD cord-335975-m6lkrehi 1319 7 more more RBR cord-335975-m6lkrehi 1319 8 efficient efficient JJ cord-335975-m6lkrehi 1319 9 than than IN cord-335975-m6lkrehi 1319 10 delta delta NN cord-335975-m6lkrehi 1319 11 SOFA sofa NN cord-335975-m6lkrehi 1319 12 ( ( -LRB- cord-335975-m6lkrehi 1319 13 NRI NRI NNP cord-335975-m6lkrehi 1319 14 = = SYM cord-335975-m6lkrehi 1319 15 8.7 8.7 CD cord-335975-m6lkrehi 1319 16 % % NN cord-335975-m6lkrehi 1319 17 ) ) -RRB- cord-335975-m6lkrehi 1319 18 to to TO cord-335975-m6lkrehi 1319 19 identify identify VB cord-335975-m6lkrehi 1319 20 patients patient NNS cord-335975-m6lkrehi 1319 21 with with IN cord-335975-m6lkrehi 1319 22 a a DT cord-335975-m6lkrehi 1319 23 85 85 CD cord-335975-m6lkrehi 1319 24 % % NN cord-335975-m6lkrehi 1319 25 mortality mortality NN cord-335975-m6lkrehi 1319 26 risk risk NN cord-335975-m6lkrehi 1319 27 at at IN cord-335975-m6lkrehi 1319 28 least least JJS cord-335975-m6lkrehi 1319 29 . . . cord-335975-m6lkrehi 1320 1 Conclusion conclusion NN cord-335975-m6lkrehi 1320 2 : : : cord-335975-m6lkrehi 1320 3 NLR NLR NNP cord-335975-m6lkrehi 1320 4 is be VBZ cord-335975-m6lkrehi 1320 5 a a DT cord-335975-m6lkrehi 1320 6 novel novel JJ cord-335975-m6lkrehi 1320 7 inflammation inflammation NN cord-335975-m6lkrehi 1320 8 index index NN cord-335975-m6lkrehi 1320 9 known know VBN cord-335975-m6lkrehi 1320 10 to to TO cord-335975-m6lkrehi 1320 11 predict predict VB cord-335975-m6lkrehi 1320 12 poor poor JJ cord-335975-m6lkrehi 1320 13 clinical clinical JJ cord-335975-m6lkrehi 1320 14 outcomes outcome NNS cord-335975-m6lkrehi 1320 15 . . . cord-335975-m6lkrehi 1321 1 Delta Delta NNP cord-335975-m6lkrehi 1321 2 NLR NLR NNP cord-335975-m6lkrehi 1321 3 is be VBZ cord-335975-m6lkrehi 1321 4 an an DT cord-335975-m6lkrehi 1321 5 independent independent JJ cord-335975-m6lkrehi 1321 6 predictor predictor NN cord-335975-m6lkrehi 1321 7 of of IN cord-335975-m6lkrehi 1321 8 mortality mortality NN cord-335975-m6lkrehi 1321 9 in in IN cord-335975-m6lkrehi 1321 10 critically critically RB cord-335975-m6lkrehi 1321 11 ill ill JJ cord-335975-m6lkrehi 1321 12 cirrhotic cirrhotic JJ cord-335975-m6lkrehi 1321 13 patients patient NNS cord-335975-m6lkrehi 1321 14 and and CC cord-335975-m6lkrehi 1321 15 could could MD cord-335975-m6lkrehi 1321 16 be be VB cord-335975-m6lkrehi 1321 17 more more RBR cord-335975-m6lkrehi 1321 18 effective effective JJ cord-335975-m6lkrehi 1321 19 than than IN cord-335975-m6lkrehi 1321 20 delta delta NN cord-335975-m6lkrehi 1321 21 SOFA sofa NN cord-335975-m6lkrehi 1321 22 in in IN cord-335975-m6lkrehi 1321 23 predicting predict VBG cord-335975-m6lkrehi 1321 24 hospital hospital NN cord-335975-m6lkrehi 1321 25 mortality mortality NN cord-335975-m6lkrehi 1321 26 in in IN cord-335975-m6lkrehi 1321 27 these these DT cord-335975-m6lkrehi 1321 28 patients patient NNS cord-335975-m6lkrehi 1321 29 . . . cord-335975-m6lkrehi 1322 1 Severe severe JJ cord-335975-m6lkrehi 1322 2 liver liver NN cord-335975-m6lkrehi 1322 3 dysfunction dysfunction NN cord-335975-m6lkrehi 1322 4 acute acute JJ cord-335975-m6lkrehi 1322 5 liver liver NN cord-335975-m6lkrehi 1322 6 failure failure NN cord-335975-m6lkrehi 1322 7 related relate VBN cord-335975-m6lkrehi 1322 8 to to IN cord-335975-m6lkrehi 1322 9 exertional exertional JJ cord-335975-m6lkrehi 1322 10 heatstroke heatstroke NN cord-335975-m6lkrehi 1322 11 : : : cord-335975-m6lkrehi 1322 12 outcomes outcome NNS cord-335975-m6lkrehi 1322 13 , , , cord-335975-m6lkrehi 1322 14 histological histological JJ cord-335975-m6lkrehi 1322 15 features feature NNS cord-335975-m6lkrehi 1322 16 and and CC cord-335975-m6lkrehi 1322 17 role role NN cord-335975-m6lkrehi 1322 18 of of IN cord-335975-m6lkrehi 1322 19 liver liver NN cord-335975-m6lkrehi 1322 20 Introduction introduction NN cord-335975-m6lkrehi 1322 21 : : : cord-335975-m6lkrehi 1322 22 Severe severe JJ cord-335975-m6lkrehi 1322 23 acute acute JJ cord-335975-m6lkrehi 1322 24 liver liver NN cord-335975-m6lkrehi 1322 25 injury injury NN cord-335975-m6lkrehi 1322 26 and and CC cord-335975-m6lkrehi 1322 27 failure failure NN cord-335975-m6lkrehi 1322 28 ( ( -LRB- cord-335975-m6lkrehi 1322 29 sALI sALI `` cord-335975-m6lkrehi 1322 30 ALF ALF NNP cord-335975-m6lkrehi 1322 31 ) ) -RRB- cord-335975-m6lkrehi 1322 32 is be VBZ cord-335975-m6lkrehi 1322 33 a a DT cord-335975-m6lkrehi 1322 34 grave grave JJ cord-335975-m6lkrehi 1322 35 complication complication NN cord-335975-m6lkrehi 1322 36 of of IN cord-335975-m6lkrehi 1322 37 exertional exertional JJ cord-335975-m6lkrehi 1322 38 heatstroke heatstroke NN cord-335975-m6lkrehi 1322 39 ( ( -LRB- cord-335975-m6lkrehi 1322 40 EH eh UH cord-335975-m6lkrehi 1322 41 ) ) -RRB- cord-335975-m6lkrehi 1322 42 . . . cord-335975-m6lkrehi 1323 1 Liver liver NN cord-335975-m6lkrehi 1323 2 transplantation transplantation NN cord-335975-m6lkrehi 1323 3 ( ( -LRB- cord-335975-m6lkrehi 1323 4 LT LT NNP cord-335975-m6lkrehi 1323 5 ) ) -RRB- cord-335975-m6lkrehi 1323 6 may may MD cord-335975-m6lkrehi 1323 7 be be VB cord-335975-m6lkrehi 1323 8 a a DT cord-335975-m6lkrehi 1323 9 therapeutic therapeutic JJ cord-335975-m6lkrehi 1323 10 option option NN cord-335975-m6lkrehi 1323 11 , , , cord-335975-m6lkrehi 1323 12 but but CC cord-335975-m6lkrehi 1323 13 the the DT cord-335975-m6lkrehi 1323 14 criteria criterion NNS cord-335975-m6lkrehi 1323 15 for for IN cord-335975-m6lkrehi 1323 16 , , , cord-335975-m6lkrehi 1323 17 and and CC cord-335975-m6lkrehi 1323 18 timing timing NN cord-335975-m6lkrehi 1323 19 of of IN cord-335975-m6lkrehi 1323 20 , , , cord-335975-m6lkrehi 1323 21 transplantation transplantation NN cord-335975-m6lkrehi 1323 22 have have VBP cord-335975-m6lkrehi 1323 23 not not RB cord-335975-m6lkrehi 1323 24 been be VBN cord-335975-m6lkrehi 1323 25 clearly clearly RB cord-335975-m6lkrehi 1323 26 established establish VBN cord-335975-m6lkrehi 1323 27 . . . cord-335975-m6lkrehi 1324 1 The the DT cord-335975-m6lkrehi 1324 2 aim aim NN cord-335975-m6lkrehi 1324 3 of of IN cord-335975-m6lkrehi 1324 4 this this DT cord-335975-m6lkrehi 1324 5 study study NN cord-335975-m6lkrehi 1324 6 was be VBD cord-335975-m6lkrehi 1324 7 to to TO cord-335975-m6lkrehi 1324 8 define define VB cord-335975-m6lkrehi 1324 9 the the DT cord-335975-m6lkrehi 1324 10 profile profile NN cord-335975-m6lkrehi 1324 11 of of IN cord-335975-m6lkrehi 1324 12 patients patient NNS cord-335975-m6lkrehi 1324 13 who who WP cord-335975-m6lkrehi 1324 14 require require VBP cord-335975-m6lkrehi 1324 15 transplantation transplantation NN cord-335975-m6lkrehi 1324 16 in in IN cord-335975-m6lkrehi 1324 17 this this DT cord-335975-m6lkrehi 1324 18 context context NN cord-335975-m6lkrehi 1324 19 . . . cord-335975-m6lkrehi 1325 1 This this DT cord-335975-m6lkrehi 1325 2 was be VBD cord-335975-m6lkrehi 1325 3 a a DT cord-335975-m6lkrehi 1325 4 multicentre multicentre NN cord-335975-m6lkrehi 1325 5 , , , cord-335975-m6lkrehi 1325 6 retrospective retrospective JJ cord-335975-m6lkrehi 1325 7 study study NN cord-335975-m6lkrehi 1325 8 of of IN cord-335975-m6lkrehi 1325 9 patients patient NNS cord-335975-m6lkrehi 1325 10 admitted admit VBN cord-335975-m6lkrehi 1325 11 with with IN cord-335975-m6lkrehi 1325 12 a a DT cord-335975-m6lkrehi 1325 13 diagnosis diagnosis NN cord-335975-m6lkrehi 1325 14 of of IN cord-335975-m6lkrehi 1325 15 exertional exertional JJ cord-335975-m6lkrehi 1325 16 heatstroke heatstroke RB cord-335975-m6lkrehi 1325 17 - - HYPH cord-335975-m6lkrehi 1325 18 related relate VBN cord-335975-m6lkrehi 1325 19 sALI sALI NNS cord-335975-m6lkrehi 1325 20 ALF ALF NNP cord-335975-m6lkrehi 1325 21 with with IN cord-335975-m6lkrehi 1325 22 a a DT cord-335975-m6lkrehi 1325 23 prothrombin prothrombin JJ cord-335975-m6lkrehi 1325 24 time time NN cord-335975-m6lkrehi 1325 25 ( ( -LRB- cord-335975-m6lkrehi 1325 26 PT pt NN cord-335975-m6lkrehi 1325 27 ) ) -RRB- cord-335975-m6lkrehi 1325 28 lower low JJR cord-335975-m6lkrehi 1325 29 than than IN cord-335975-m6lkrehi 1325 30 50 50 CD cord-335975-m6lkrehi 1325 31 % % NN cord-335975-m6lkrehi 1325 32 , , , cord-335975-m6lkrehi 1325 33 with with IN cord-335975-m6lkrehi 1325 34 or or CC cord-335975-m6lkrehi 1325 35 without without IN cord-335975-m6lkrehi 1325 36 hepatic hepatic JJ cord-335975-m6lkrehi 1325 37 encephalopathy encephalopathy NN cord-335975-m6lkrehi 1325 38 . . . cord-335975-m6lkrehi 1326 1 Results result NNS cord-335975-m6lkrehi 1326 2 : : : cord-335975-m6lkrehi 1327 1 24 24 CD cord-335975-m6lkrehi 1327 2 male male JJ cord-335975-m6lkrehi 1327 3 patients patient NNS cord-335975-m6lkrehi 1327 4 ( ( -LRB- cord-335975-m6lkrehi 1327 5 median median NN cord-335975-m6lkrehi 1327 6 age-27.5 age-27.5 NNP cord-335975-m6lkrehi 1327 7 years year NNS cord-335975-m6lkrehi 1327 8 ) ) -RRB- cord-335975-m6lkrehi 1327 9 with with IN cord-335975-m6lkrehi 1327 10 ALI ALI NNP cord-335975-m6lkrehi 1327 11 ALF ALF NNP cord-335975-m6lkrehi 1327 12 related relate VBN cord-335975-m6lkrehi 1327 13 to to IN cord-335975-m6lkrehi 1327 14 exertional exertional JJ cord-335975-m6lkrehi 1327 15 heatstroke heatstroke NN cord-335975-m6lkrehi 1327 16 were be VBD cord-335975-m6lkrehi 1327 17 studied study VBN cord-335975-m6lkrehi 1327 18 + + CC cord-335975-m6lkrehi 1327 19 nine nine CD cord-335975-m6lkrehi 1327 20 of of IN cord-335975-m6lkrehi 1327 21 them -PRON- PRP cord-335975-m6lkrehi 1327 22 ( ( -LRB- cord-335975-m6lkrehi 1327 23 37.5 37.5 CD cord-335975-m6lkrehi 1327 24 % % NN cord-335975-m6lkrehi 1327 25 ) ) -RRB- cord-335975-m6lkrehi 1327 26 were be VBD cord-335975-m6lkrehi 1327 27 listed list VBN cord-335975-m6lkrehi 1327 28 for for IN cord-335975-m6lkrehi 1327 29 emergency emergency NN cord-335975-m6lkrehi 1327 30 LT LT NNP cord-335975-m6lkrehi 1327 31 . . . cord-335975-m6lkrehi 1328 1 The the DT cord-335975-m6lkrehi 1328 2 latter latter NN cord-335975-m6lkrehi 1328 3 differed differ VBD cord-335975-m6lkrehi 1328 4 from from IN cord-335975-m6lkrehi 1328 5 those those DT cord-335975-m6lkrehi 1328 6 who who WP cord-335975-m6lkrehi 1328 7 were be VBD cord-335975-m6lkrehi 1328 8 not not RB cord-335975-m6lkrehi 1328 9 listed list VBN cord-335975-m6lkrehi 1328 10 with with IN cord-335975-m6lkrehi 1328 11 respect respect NN cord-335975-m6lkrehi 1328 12 to to IN cord-335975-m6lkrehi 1328 13 their -PRON- PRP$ cord-335975-m6lkrehi 1328 14 more more RBR cord-335975-m6lkrehi 1328 15 severe severe JJ cord-335975-m6lkrehi 1328 16 liver liver NN cord-335975-m6lkrehi 1328 17 failure failure NN cord-335975-m6lkrehi 1328 18 after after IN cord-335975-m6lkrehi 1328 19 D1 d1 NN cord-335975-m6lkrehi 1328 20 , , , cord-335975-m6lkrehi 1328 21 a a DT cord-335975-m6lkrehi 1328 22 clear clear JJ cord-335975-m6lkrehi 1328 23 deterioration deterioration NN cord-335975-m6lkrehi 1328 24 in in IN cord-335975-m6lkrehi 1328 25 their -PRON- PRP$ cord-335975-m6lkrehi 1328 26 PT pt NN cord-335975-m6lkrehi 1328 27 and and CC cord-335975-m6lkrehi 1328 28 ALT alt NN cord-335975-m6lkrehi 1328 29 values value NNS cord-335975-m6lkrehi 1328 30 between between IN cord-335975-m6lkrehi 1328 31 D0 d0 NN cord-335975-m6lkrehi 1328 32 and and CC cord-335975-m6lkrehi 1328 33 D3 D3 NNP cord-335975-m6lkrehi 1328 34 , , , cord-335975-m6lkrehi 1328 35 and and CC cord-335975-m6lkrehi 1328 36 more more RBR cord-335975-m6lkrehi 1328 37 marked marked JJ cord-335975-m6lkrehi 1328 38 organ organ NN cord-335975-m6lkrehi 1328 39 dysfunction dysfunction NN cord-335975-m6lkrehi 1328 40 . . . cord-335975-m6lkrehi 1329 1 Four four CD cord-335975-m6lkrehi 1329 2 of of IN cord-335975-m6lkrehi 1329 3 these these DT cord-335975-m6lkrehi 1329 4 nine nine CD cord-335975-m6lkrehi 1329 5 patients patient NNS cord-335975-m6lkrehi 1329 6 were be VBD cord-335975-m6lkrehi 1329 7 subsequently subsequently RB cord-335975-m6lkrehi 1329 8 transplanted transplant VBN cord-335975-m6lkrehi 1329 9 . . . cord-335975-m6lkrehi 1330 1 At at IN cord-335975-m6lkrehi 1330 2 the the DT cord-335975-m6lkrehi 1330 3 time time NN cord-335975-m6lkrehi 1330 4 of of IN cord-335975-m6lkrehi 1330 5 LT LT NNP cord-335975-m6lkrehi 1330 6 , , , cord-335975-m6lkrehi 1330 7 all all DT cord-335975-m6lkrehi 1330 8 had have VBD cord-335975-m6lkrehi 1330 9 PT pt NN cord-335975-m6lkrehi 1330 10 levels level NNS cord-335975-m6lkrehi 1330 11 lower low JJR cord-335975-m6lkrehi 1330 12 than than IN cord-335975-m6lkrehi 1330 13 10 10 CD cord-335975-m6lkrehi 1330 14 % % NN cord-335975-m6lkrehi 1330 15 , , , cord-335975-m6lkrehi 1330 16 a a DT cord-335975-m6lkrehi 1330 17 marked marked JJ cord-335975-m6lkrehi 1330 18 rise rise NN cord-335975-m6lkrehi 1330 19 in in IN cord-335975-m6lkrehi 1330 20 bilirubin bilirubin NN cord-335975-m6lkrehi 1330 21 levels level NNS cord-335975-m6lkrehi 1330 22 and and CC cord-335975-m6lkrehi 1330 23 required require VBN cord-335975-m6lkrehi 1330 24 support support NN cord-335975-m6lkrehi 1330 25 for for IN cord-335975-m6lkrehi 1330 26 at at RB cord-335975-m6lkrehi 1330 27 least least RBS cord-335975-m6lkrehi 1330 28 one one CD cord-335975-m6lkrehi 1330 29 organ organ NN cord-335975-m6lkrehi 1330 30 ( ( -LRB- cord-335975-m6lkrehi 1330 31 or or CC cord-335975-m6lkrehi 1330 32 x x CD cord-335975-m6lkrehi 1330 33 organs organ NNS cord-335975-m6lkrehi 1330 34 were be VBD cord-335975-m6lkrehi 1330 35 involved involve VBN cord-335975-m6lkrehi 1330 36 ) ) -RRB- cord-335975-m6lkrehi 1330 37 . . . cord-335975-m6lkrehi 1331 1 Histological Histological NNP cord-335975-m6lkrehi 1331 2 findings finding NNS cord-335975-m6lkrehi 1331 3 on on IN cord-335975-m6lkrehi 1331 4 the the DT cord-335975-m6lkrehi 1331 5 explanted explante VBN cord-335975-m6lkrehi 1331 6 livers liver NNS cord-335975-m6lkrehi 1331 7 demonstrated demonstrate VBD cord-335975-m6lkrehi 1331 8 massive massive JJ cord-335975-m6lkrehi 1331 9 or or CC cord-335975-m6lkrehi 1331 10 sub sub JJ cord-335975-m6lkrehi 1331 11 - - JJ cord-335975-m6lkrehi 1331 12 massive massive JJ cord-335975-m6lkrehi 1331 13 necrosis necrosis NN cord-335975-m6lkrehi 1331 14 and and CC cord-335975-m6lkrehi 1331 15 little little JJ cord-335975-m6lkrehi 1331 16 potential potential NN cord-335975-m6lkrehi 1331 17 for for IN cord-335975-m6lkrehi 1331 18 effective effective JJ cord-335975-m6lkrehi 1331 19 mitosis mitosis NN cord-335975-m6lkrehi 1331 20 with with IN cord-335975-m6lkrehi 1331 21 a a DT cord-335975-m6lkrehi 1331 22 mitonecrotic mitonecrotic JJ cord-335975-m6lkrehi 1331 23 appearance appearance NN cord-335975-m6lkrehi 1331 24 . . . cord-335975-m6lkrehi 1332 1 The the DT cord-335975-m6lkrehi 1332 2 15 15 CD cord-335975-m6lkrehi 1332 3 unlisted unlisted JJ cord-335975-m6lkrehi 1332 4 patients patient NNS cord-335975-m6lkrehi 1332 5 ( ( -LRB- cord-335975-m6lkrehi 1332 6 62.5 62.5 CD cord-335975-m6lkrehi 1332 7 % % NN cord-335975-m6lkrehi 1332 8 ) ) -RRB- cord-335975-m6lkrehi 1332 9 were be VBD cord-335975-m6lkrehi 1332 10 still still RB cord-335975-m6lkrehi 1332 11 alive alive JJ cord-335975-m6lkrehi 1332 12 6 6 CD cord-335975-m6lkrehi 1332 13 months month NNS cord-335975-m6lkrehi 1332 14 later later RB cord-335975-m6lkrehi 1332 15 and and CC cord-335975-m6lkrehi 1332 16 had have VBD cord-335975-m6lkrehi 1332 17 not not RB cord-335975-m6lkrehi 1332 18 experienced experience VBN cord-335975-m6lkrehi 1332 19 any any DT cord-335975-m6lkrehi 1332 20 after after NN cord-335975-m6lkrehi 1332 21 - - HYPH cord-335975-m6lkrehi 1332 22 effects effect NNS cord-335975-m6lkrehi 1332 23 . . . cord-335975-m6lkrehi 1333 1 Conclusion conclusion NN cord-335975-m6lkrehi 1333 2 : : : cord-335975-m6lkrehi 1334 1 Survival survival NN cord-335975-m6lkrehi 1334 2 without without IN cord-335975-m6lkrehi 1334 3 liver liver NN cord-335975-m6lkrehi 1334 4 transplantation transplantation NN cord-335975-m6lkrehi 1334 5 in in IN cord-335975-m6lkrehi 1334 6 patients patient NNS cord-335975-m6lkrehi 1334 7 with with IN cord-335975-m6lkrehi 1334 8 heatstroke heatstroke RB cord-335975-m6lkrehi 1334 9 - - HYPH cord-335975-m6lkrehi 1334 10 related relate VBN cord-335975-m6lkrehi 1334 11 ALI ALI NNP cord-335975-m6lkrehi 1334 12 ALF ALF NNP cord-335975-m6lkrehi 1334 13 reaches reach VBZ cord-335975-m6lkrehi 1334 14 83.5 83.5 CD cord-335975-m6lkrehi 1334 15 % % NN cord-335975-m6lkrehi 1334 16 . . . cord-335975-m6lkrehi 1335 1 The the DT cord-335975-m6lkrehi 1335 2 indication indication NN cord-335975-m6lkrehi 1335 3 for for IN cord-335975-m6lkrehi 1335 4 liver liver NN cord-335975-m6lkrehi 1335 5 transplantation transplantation NN cord-335975-m6lkrehi 1335 6 is be VBZ cord-335975-m6lkrehi 1335 7 based base VBN cord-335975-m6lkrehi 1335 8 on on IN cord-335975-m6lkrehi 1335 9 an an DT cord-335975-m6lkrehi 1335 10 evolving evolve VBG cord-335975-m6lkrehi 1335 11 dynamic dynamic JJ cord-335975-m6lkrehi 1335 12 . . . cord-335975-m6lkrehi 1336 1 The the DT cord-335975-m6lkrehi 1336 2 lack lack NN cord-335975-m6lkrehi 1336 3 of of IN cord-335975-m6lkrehi 1336 4 any any DT cord-335975-m6lkrehi 1336 5 signs sign NNS cord-335975-m6lkrehi 1336 6 of of IN cord-335975-m6lkrehi 1336 7 an an DT cord-335975-m6lkrehi 1336 8 improvement improvement NN cord-335975-m6lkrehi 1336 9 in in IN cord-335975-m6lkrehi 1336 10 liver liver NN cord-335975-m6lkrehi 1336 11 function function NN cord-335975-m6lkrehi 1336 12 at at IN cord-335975-m6lkrehi 1336 13 or or CC cord-335975-m6lkrehi 1336 14 after after IN cord-335975-m6lkrehi 1336 15 D3 D3 NNP cord-335975-m6lkrehi 1336 16 , , , cord-335975-m6lkrehi 1336 17 in in IN cord-335975-m6lkrehi 1336 18 patients patient NNS cord-335975-m6lkrehi 1336 19 presenting present VBG cord-335975-m6lkrehi 1336 20 with with IN cord-335975-m6lkrehi 1336 21 other other JJ cord-335975-m6lkrehi 1336 22 organ organ NN cord-335975-m6lkrehi 1336 23 dysfunctions dysfunction NNS cord-335975-m6lkrehi 1336 24 or or CC cord-335975-m6lkrehi 1336 25 failure failure NN cord-335975-m6lkrehi 1336 26 , , , cord-335975-m6lkrehi 1336 27 means mean VBZ cord-335975-m6lkrehi 1336 28 that that IN cord-335975-m6lkrehi 1336 29 liver liver NN cord-335975-m6lkrehi 1336 30 transplantation transplantation NN cord-335975-m6lkrehi 1336 31 should should MD cord-335975-m6lkrehi 1336 32 be be VB cord-335975-m6lkrehi 1336 33 envisaged envisage VBN cord-335975-m6lkrehi 1336 34 . . . cord-335975-m6lkrehi 1337 1 The the DT cord-335975-m6lkrehi 1337 2 peculiar peculiar JJ cord-335975-m6lkrehi 1337 3 histological histological JJ cord-335975-m6lkrehi 1337 4 features feature NNS cord-335975-m6lkrehi 1337 5 observed observe VBN cord-335975-m6lkrehi 1337 6 on on IN cord-335975-m6lkrehi 1337 7 all all PDT cord-335975-m6lkrehi 1337 8 the the DT cord-335975-m6lkrehi 1337 9 explanted explante VBN cord-335975-m6lkrehi 1337 10 livers liver NNS cord-335975-m6lkrehi 1337 11 , , , cord-335975-m6lkrehi 1337 12 and and CC cord-335975-m6lkrehi 1337 13 the the DT cord-335975-m6lkrehi 1337 14 aspect aspect NN cord-335975-m6lkrehi 1337 15 of of IN cord-335975-m6lkrehi 1337 16 abortive abortive JJ cord-335975-m6lkrehi 1337 17 mitoses mitose NNS cord-335975-m6lkrehi 1337 18 in in IN cord-335975-m6lkrehi 1337 19 hepatocytes hepatocyte NNS cord-335975-m6lkrehi 1337 20 could could MD cord-335975-m6lkrehi 1337 21 be be VB cord-335975-m6lkrehi 1337 22 attributed attribute VBN cord-335975-m6lkrehi 1337 23 to to IN cord-335975-m6lkrehi 1337 24 the the DT cord-335975-m6lkrehi 1337 25 effects effect NNS cord-335975-m6lkrehi 1337 26 of of IN cord-335975-m6lkrehi 1337 27 heatstroke heatstroke NN cord-335975-m6lkrehi 1337 28 . . . cord-335975-m6lkrehi 1337 29 . . . cord-335975-m6lkrehi 1338 1 On on IN cord-335975-m6lkrehi 1338 2 admission admission NN cord-335975-m6lkrehi 1338 3 , , , cord-335975-m6lkrehi 1338 4 the the DT cord-335975-m6lkrehi 1338 5 mean mean NN cord-335975-m6lkrehi 1338 6 PT PT NNP cord-335975-m6lkrehi 1338 7 was be VBD cord-335975-m6lkrehi 1338 8 18.5 18.5 CD cord-335975-m6lkrehi 1338 9 % % NN cord-335975-m6lkrehi 1338 10 ( ( -LRB- cord-335975-m6lkrehi 1338 11 8 8 CD cord-335975-m6lkrehi 1338 12 - - SYM cord-335975-m6lkrehi 1338 13 42 42 CD cord-335975-m6lkrehi 1338 14 ) ) -RRB- cord-335975-m6lkrehi 1338 15 , , , cord-335975-m6lkrehi 1338 16 the the DT cord-335975-m6lkrehi 1338 17 mean mean JJ cord-335975-m6lkrehi 1338 18 total total JJ cord-335975-m6lkrehi 1338 19 bilirubin bilirubin NN cord-335975-m6lkrehi 1338 20 was be VBD cord-335975-m6lkrehi 1338 21 157 157 CD cord-335975-m6lkrehi 1338 22 umol umol NN cord-335975-m6lkrehi 1339 1 l. l. NNP cord-335975-m6lkrehi 1339 2 Paracetamol Paracetamol NNP cord-335975-m6lkrehi 1339 3 poisoning poisoning NN cord-335975-m6lkrehi 1339 4 was be VBD cord-335975-m6lkrehi 1339 5 the the DT cord-335975-m6lkrehi 1339 6 principal principal JJ cord-335975-m6lkrehi 1339 7 etiology etiology NN cord-335975-m6lkrehi 1339 8 with with IN cord-335975-m6lkrehi 1339 9 45 45 CD cord-335975-m6lkrehi 1339 10 % % NN cord-335975-m6lkrehi 1339 11 of of IN cord-335975-m6lkrehi 1339 12 the the DT cord-335975-m6lkrehi 1339 13 patients-66 patients-66 JJ cord-335975-m6lkrehi 1339 14 % % NN cord-335975-m6lkrehi 1339 15 in in IN cord-335975-m6lkrehi 1339 16 the the DT cord-335975-m6lkrehi 1339 17 Prometheus Prometheus NNP cord-335975-m6lkrehi 1339 18 group group NN cord-335975-m6lkrehi 1339 19 versus versus IN cord-335975-m6lkrehi 1339 20 25 25 CD cord-335975-m6lkrehi 1339 21 % % NN cord-335975-m6lkrehi 1339 22 in in IN cord-335975-m6lkrehi 1339 23 the the DT cord-335975-m6lkrehi 1339 24 standard standard JJ cord-335975-m6lkrehi 1339 25 group group NN cord-335975-m6lkrehi 1339 26 ( ( -LRB- cord-335975-m6lkrehi 1339 27 p p NN cord-335975-m6lkrehi 1339 28 = = SYM cord-335975-m6lkrehi 1339 29 0.106 0.106 CD cord-335975-m6lkrehi 1339 30 ) ) -RRB- cord-335975-m6lkrehi 1339 31 . . . cord-335975-m6lkrehi 1340 1 The the DT cord-335975-m6lkrehi 1340 2 hepatic hepatic JJ cord-335975-m6lkrehi 1340 3 encephalopathy encephalopathy NN cord-335975-m6lkrehi 1340 4 grade grade NN cord-335975-m6lkrehi 1340 5 was be VBD cord-335975-m6lkrehi 1340 6 significantly significantly RB cord-335975-m6lkrehi 1340 7 higher high JJR cord-335975-m6lkrehi 1340 8 in in IN cord-335975-m6lkrehi 1340 9 the the DT cord-335975-m6lkrehi 1340 10 Prometheus Prometheus NNP cord-335975-m6lkrehi 1340 11 group-3 group-3 NNP cord-335975-m6lkrehi 1340 12 versus versus IN cord-335975-m6lkrehi 1340 13 0.5 0.5 CD cord-335975-m6lkrehi 1340 14 in in IN cord-335975-m6lkrehi 1340 15 the the DT cord-335975-m6lkrehi 1340 16 standard standard JJ cord-335975-m6lkrehi 1340 17 group group NN cord-335975-m6lkrehi 1340 18 ( ( -LRB- cord-335975-m6lkrehi 1340 19 p p NN cord-335975-m6lkrehi 1340 20 = = SYM cord-335975-m6lkrehi 1340 21 0.029 0.029 CD cord-335975-m6lkrehi 1340 22 ) ) -RRB- cord-335975-m6lkrehi 1340 23 . . . cord-335975-m6lkrehi 1341 1 There there EX cord-335975-m6lkrehi 1341 2 was be VBD cord-335975-m6lkrehi 1341 3 no no DT cord-335975-m6lkrehi 1341 4 difference difference NN cord-335975-m6lkrehi 1341 5 between between IN cord-335975-m6lkrehi 1341 6 the the DT cord-335975-m6lkrehi 1341 7 two two CD cord-335975-m6lkrehi 1341 8 groups group NNS cord-335975-m6lkrehi 1341 9 concerning concern VBG cord-335975-m6lkrehi 1341 10 mortality mortality NN cord-335975-m6lkrehi 1341 11 on on IN cord-335975-m6lkrehi 1341 12 day day NN cord-335975-m6lkrehi 1341 13 28 28 CD cord-335975-m6lkrehi 1341 14 ( ( -LRB- cord-335975-m6lkrehi 1341 15 p p NN cord-335975-m6lkrehi 1341 16 = = SYM cord-335975-m6lkrehi 1341 17 1 1 CD cord-335975-m6lkrehi 1341 18 ) ) -RRB- cord-335975-m6lkrehi 1341 19 or or CC cord-335975-m6lkrehi 1341 20 day day NN cord-335975-m6lkrehi 1341 21 90 90 CD cord-335975-m6lkrehi 1341 22 ( ( -LRB- cord-335975-m6lkrehi 1341 23 p p NN cord-335975-m6lkrehi 1341 24 = = SYM cord-335975-m6lkrehi 1341 25 0.59 0.59 CD cord-335975-m6lkrehi 1341 26 ) ) -RRB- cord-335975-m6lkrehi 1341 27 . . . cord-335975-m6lkrehi 1342 1 There there EX cord-335975-m6lkrehi 1342 2 was be VBD cord-335975-m6lkrehi 1342 3 no no DT cord-335975-m6lkrehi 1342 4 difference difference NN cord-335975-m6lkrehi 1342 5 concerning concern VBG cord-335975-m6lkrehi 1342 6 the the DT cord-335975-m6lkrehi 1342 7 length length NN cord-335975-m6lkrehi 1342 8 of of IN cord-335975-m6lkrehi 1342 9 stay stay NN cord-335975-m6lkrehi 1342 10 in in IN cord-335975-m6lkrehi 1342 11 intensive intensive JJ cord-335975-m6lkrehi 1342 12 care care NN cord-335975-m6lkrehi 1342 13 unit unit NN cord-335975-m6lkrehi 1342 14 or or CC cord-335975-m6lkrehi 1342 15 in in IN cord-335975-m6lkrehi 1342 16 hospital hospital NN cord-335975-m6lkrehi 1342 17 between between IN cord-335975-m6lkrehi 1342 18 the the DT cord-335975-m6lkrehi 1342 19 two two CD cord-335975-m6lkrehi 1342 20 groups group NNS cord-335975-m6lkrehi 1342 21 . . . cord-335975-m6lkrehi 1343 1 13 13 CD cord-335975-m6lkrehi 1343 2 patients patient NNS cord-335975-m6lkrehi 1343 3 ( ( -LRB- cord-335975-m6lkrehi 1343 4 37.1 37.1 CD cord-335975-m6lkrehi 1343 5 % % NN cord-335975-m6lkrehi 1343 6 ) ) -RRB- cord-335975-m6lkrehi 1343 7 were be VBD cord-335975-m6lkrehi 1343 8 transplanted transplant VBN cord-335975-m6lkrehi 1343 9 . . . cord-335975-m6lkrehi 1344 1 There there EX cord-335975-m6lkrehi 1344 2 was be VBD cord-335975-m6lkrehi 1344 3 a a DT cord-335975-m6lkrehi 1344 4 statistical statistical JJ cord-335975-m6lkrehi 1344 5 difference difference NN cord-335975-m6lkrehi 1344 6 between between IN cord-335975-m6lkrehi 1344 7 the the DT cord-335975-m6lkrehi 1344 8 two two CD cord-335975-m6lkrehi 1344 9 groups group NNS cord-335975-m6lkrehi 1344 10 concerning concern VBG cord-335975-m6lkrehi 1344 11 liver liver NN cord-335975-m6lkrehi 1344 12 transplantation transplantation NN cord-335975-m6lkrehi 1344 13 ( ( -LRB- cord-335975-m6lkrehi 1344 14 p p NN cord-335975-m6lkrehi 1344 15 = = SYM cord-335975-m6lkrehi 1344 16 0.041)-4 0.041)-4 CD cord-335975-m6lkrehi 1344 17 transplant transplant NN cord-335975-m6lkrehi 1344 18 ( ( -LRB- cord-335975-m6lkrehi 1344 19 40 40 CD cord-335975-m6lkrehi 1344 20 % % NN cord-335975-m6lkrehi 1344 21 ) ) -RRB- cord-335975-m6lkrehi 1344 22 in in IN cord-335975-m6lkrehi 1344 23 the the DT cord-335975-m6lkrehi 1344 24 Prometheus Prometheus NNP cord-335975-m6lkrehi 1344 25 group group NN cord-335975-m6lkrehi 1344 26 versus versus IN cord-335975-m6lkrehi 1344 27 9 9 CD cord-335975-m6lkrehi 1344 28 transplant transplant NN cord-335975-m6lkrehi 1344 29 ( ( -LRB- cord-335975-m6lkrehi 1344 30 75 75 CD cord-335975-m6lkrehi 1344 31 % % NN cord-335975-m6lkrehi 1344 32 ) ) -RRB- cord-335975-m6lkrehi 1344 33 in in IN cord-335975-m6lkrehi 1344 34 the the DT cord-335975-m6lkrehi 1344 35 standard standard JJ cord-335975-m6lkrehi 1344 36 medical medical JJ cord-335975-m6lkrehi 1344 37 care care NN cord-335975-m6lkrehi 1344 38 group group NN cord-335975-m6lkrehi 1344 39 . . . cord-335975-m6lkrehi 1345 1 There there EX cord-335975-m6lkrehi 1345 2 was be VBD cord-335975-m6lkrehi 1345 3 a a DT cord-335975-m6lkrehi 1345 4 significant significant JJ cord-335975-m6lkrehi 1345 5 improve improve NN cord-335975-m6lkrehi 1345 6 of of IN cord-335975-m6lkrehi 1345 7 encephalopathy encephalopathy NN cord-335975-m6lkrehi 1345 8 after after IN cord-335975-m6lkrehi 1345 9 the the DT cord-335975-m6lkrehi 1345 10 Prometheus Prometheus NNP cord-335975-m6lkrehi 1345 11 session session NN cord-335975-m6lkrehi 1345 12 ( ( -LRB- cord-335975-m6lkrehi 1345 13 p p NN cord-335975-m6lkrehi 1345 14 = = SYM cord-335975-m6lkrehi 1345 15 0.002 0.002 CD cord-335975-m6lkrehi 1345 16 ) ) -RRB- cord-335975-m6lkrehi 1345 17 . . . cord-335975-m6lkrehi 1346 1 therapy therapy NN cord-335975-m6lkrehi 1346 2 in in IN cord-335975-m6lkrehi 1346 3 our -PRON- PRP$ cord-335975-m6lkrehi 1346 4 ICU ICU NNP cord-335975-m6lkrehi 1346 5 were be VBD cord-335975-m6lkrehi 1346 6 included include VBN cord-335975-m6lkrehi 1346 7 consecutively consecutively RB cord-335975-m6lkrehi 1346 8 and and CC cord-335975-m6lkrehi 1346 9 prospectively prospectively RB cord-335975-m6lkrehi 1346 10 in in IN cord-335975-m6lkrehi 1346 11 the the DT cord-335975-m6lkrehi 1346 12 cohort cohort NN cord-335975-m6lkrehi 1346 13 . . . cord-335975-m6lkrehi 1347 1 MARS MARS NNP cord-335975-m6lkrehi 1348 1 ® ® NNP cord-335975-m6lkrehi 1348 2 therapy therapy NN cord-335975-m6lkrehi 1348 3 performed perform VBN cord-335975-m6lkrehi 1348 4 using use VBG cord-335975-m6lkrehi 1348 5 a a DT cord-335975-m6lkrehi 1348 6 double double JJ cord-335975-m6lkrehi 1348 7 lumen lumen JJ cord-335975-m6lkrehi 1348 8 dialysis dialysis NN cord-335975-m6lkrehi 1348 9 catheter catheter NN cord-335975-m6lkrehi 1348 10 in in IN cord-335975-m6lkrehi 1348 11 the the DT cord-335975-m6lkrehi 1348 12 femoral femoral JJ cord-335975-m6lkrehi 1348 13 or or CC cord-335975-m6lkrehi 1348 14 jugular jugular NN cord-335975-m6lkrehi 1348 15 vein vein NN cord-335975-m6lkrehi 1348 16 . . . cord-335975-m6lkrehi 1349 1 We -PRON- PRP cord-335975-m6lkrehi 1349 2 used use VBD cord-335975-m6lkrehi 1349 3 the the DT cord-335975-m6lkrehi 1349 4 monitor monitor NN cord-335975-m6lkrehi 1349 5 MARS MARS NNP cord-335975-m6lkrehi 1350 1 ® ® LS cord-335975-m6lkrehi 1350 2 1 1 CD cord-335975-m6lkrehi 1350 3 TC TC NNP cord-335975-m6lkrehi 1350 4 ( ( -LRB- cord-335975-m6lkrehi 1350 5 Teraklin Teraklin NNP cord-335975-m6lkrehi 1350 6 ) ) -RRB- cord-335975-m6lkrehi 1350 7 coupled couple VBN cord-335975-m6lkrehi 1350 8 with with IN cord-335975-m6lkrehi 1350 9 the the DT cord-335975-m6lkrehi 1350 10 dialysis dialysis NN cord-335975-m6lkrehi 1350 11 machine machine NN cord-335975-m6lkrehi 1350 12 Prismaflex Prismaflex NNP cord-335975-m6lkrehi 1350 13 ® ® . cord-335975-m6lkrehi 1350 14 ( ( -LRB- cord-335975-m6lkrehi 1350 15 Gambro Gambro NNP cord-335975-m6lkrehi 1350 16 ) ) -RRB- cord-335975-m6lkrehi 1350 17 . . . cord-335975-m6lkrehi 1351 1 The the DT cord-335975-m6lkrehi 1351 2 albumin albumin NN cord-335975-m6lkrehi 1351 3 dialysate dialysate NN cord-335975-m6lkrehi 1351 4 circuit circuit NN cord-335975-m6lkrehi 1351 5 consisted consist VBD cord-335975-m6lkrehi 1351 6 of of IN cord-335975-m6lkrehi 1351 7 500 500 CD cord-335975-m6lkrehi 1351 8 ml ml NNS cord-335975-m6lkrehi 1351 9 of of IN cord-335975-m6lkrehi 1351 10 20 20 CD cord-335975-m6lkrehi 1351 11 % % NN cord-335975-m6lkrehi 1351 12 human human JJ cord-335975-m6lkrehi 1351 13 albumin albumin NN cord-335975-m6lkrehi 1351 14 and and CC cord-335975-m6lkrehi 1351 15 was be VBD cord-335975-m6lkrehi 1351 16 regenerated regenerate VBN cord-335975-m6lkrehi 1351 17 by by IN cord-335975-m6lkrehi 1351 18 an an DT cord-335975-m6lkrehi 1351 19 anion anion NN cord-335975-m6lkrehi 1351 20 - - HYPH cord-335975-m6lkrehi 1351 21 exchange exchange NN cord-335975-m6lkrehi 1351 22 column column NN cord-335975-m6lkrehi 1351 23 and and CC cord-335975-m6lkrehi 1351 24 an an DT cord-335975-m6lkrehi 1351 25 uncoated uncoated JJ cord-335975-m6lkrehi 1351 26 charcoal charcoal NN cord-335975-m6lkrehi 1351 27 column column NN cord-335975-m6lkrehi 1351 28 ( ( -LRB- cord-335975-m6lkrehi 1351 29 diaMARS diaMARS NNP cord-335975-m6lkrehi 1352 1 ® ® NNP cord-335975-m6lkrehi 1352 2 IE250 IE250 NNP cord-335975-m6lkrehi 1352 3 , , , cord-335975-m6lkrehi 1352 4 diaMARS diaMARS NNP cord-335975-m6lkrehi 1353 1 ® ® . cord-335975-m6lkrehi 1354 1 AC250 AC250 NNP cord-335975-m6lkrehi 1354 2 ) ) -RRB- cord-335975-m6lkrehi 1354 3 . . . cord-335975-m6lkrehi 1355 1 Results result NNS cord-335975-m6lkrehi 1355 2 : : : cord-335975-m6lkrehi 1356 1 Ninety ninety CD cord-335975-m6lkrehi 1356 2 patients patient NNS cord-335975-m6lkrehi 1356 3 were be VBD cord-335975-m6lkrehi 1356 4 included include VBN cord-335975-m6lkrehi 1356 5 for for IN cord-335975-m6lkrehi 1356 6 300 300 CD cord-335975-m6lkrehi 1356 7 sessions session NNS cord-335975-m6lkrehi 1356 8 . . . cord-335975-m6lkrehi 1357 1 The the DT cord-335975-m6lkrehi 1357 2 mean mean JJ cord-335975-m6lkrehi 1357 3 duration duration NN cord-335975-m6lkrehi 1357 4 was be VBD cord-335975-m6lkrehi 1357 5 7 7 CD cord-335975-m6lkrehi 1357 6 h h NN cord-335975-m6lkrehi 1357 7 38 38 CD cord-335975-m6lkrehi 1357 8 min min NN cord-335975-m6lkrehi 1357 9 ( ( -LRB- cord-335975-m6lkrehi 1357 10 ± ± NNP cord-335975-m6lkrehi 1357 11 1 1 CD cord-335975-m6lkrehi 1357 12 h h NN cord-335975-m6lkrehi 1357 13 43 43 CD cord-335975-m6lkrehi 1357 14 min min NN cord-335975-m6lkrehi 1357 15 ) ) -RRB- cord-335975-m6lkrehi 1357 16 . . . cord-335975-m6lkrehi 1358 1 The the DT cord-335975-m6lkrehi 1358 2 population population NN cord-335975-m6lkrehi 1358 3 treated treat VBD cord-335975-m6lkrehi 1358 4 consisted consist VBD cord-335975-m6lkrehi 1358 5 of of IN cord-335975-m6lkrehi 1358 6 5 5 CD cord-335975-m6lkrehi 1358 7 groups group NNS cord-335975-m6lkrehi 1358 8 - - HYPH cord-335975-m6lkrehi 1358 9 acute acute JJ cord-335975-m6lkrehi 1358 10 - - HYPH cord-335975-m6lkrehi 1358 11 on on IN cord-335975-m6lkrehi 1358 12 - - HYPH cord-335975-m6lkrehi 1358 13 chronic chronic JJ cord-335975-m6lkrehi 1358 14 liver liver NN cord-335975-m6lkrehi 1358 15 failure failure NN cord-335975-m6lkrehi 1358 16 ( ( -LRB- cord-335975-m6lkrehi 1358 17 AoCLF AoCLF NNP cord-335975-m6lkrehi 1358 18 ) ) -RRB- cord-335975-m6lkrehi 1358 19 , , , cord-335975-m6lkrehi 1358 20 acute acute JJ cord-335975-m6lkrehi 1358 21 liver liver NN cord-335975-m6lkrehi 1358 22 failure failure NN cord-335975-m6lkrehi 1358 23 ( ( -LRB- cord-335975-m6lkrehi 1358 24 ALF ALF NNP cord-335975-m6lkrehi 1358 25 ) ) -RRB- cord-335975-m6lkrehi 1358 26 , , , cord-335975-m6lkrehi 1358 27 post post JJ cord-335975-m6lkrehi 1358 28 - - JJ cord-335975-m6lkrehi 1358 29 surgery surgery JJ cord-335975-m6lkrehi 1358 30 liver liver NN cord-335975-m6lkrehi 1358 31 failure failure NN cord-335975-m6lkrehi 1358 32 ( ( -LRB- cord-335975-m6lkrehi 1358 33 post post NN cord-335975-m6lkrehi 1358 34 transplantation transplantation NN cord-335975-m6lkrehi 1358 35 , , , cord-335975-m6lkrehi 1358 36 post post NN cord-335975-m6lkrehi 1358 37 hepatectomy hepatectomy NNP cord-335975-m6lkrehi 1358 38 ) ) -RRB- cord-335975-m6lkrehi 1358 39 , , , cord-335975-m6lkrehi 1358 40 refractory refractory JJ cord-335975-m6lkrehi 1358 41 pruritus pruritus NN cord-335975-m6lkrehi 1358 42 and and CC cord-335975-m6lkrehi 1358 43 drug drug NN cord-335975-m6lkrehi 1358 44 intoxication intoxication NN cord-335975-m6lkrehi 1358 45 ( ( -LRB- cord-335975-m6lkrehi 1358 46 Fig Fig NNP cord-335975-m6lkrehi 1358 47 . . . cord-335975-m6lkrehi 1358 48 1 1 CD cord-335975-m6lkrehi 1358 49 ) ) -RRB- cord-335975-m6lkrehi 1358 50 . . . cord-335975-m6lkrehi 1359 1 Regarding regard VBG cord-335975-m6lkrehi 1359 2 biological biological JJ cord-335975-m6lkrehi 1359 3 efficacy efficacy NN cord-335975-m6lkrehi 1359 4 - - HYPH cord-335975-m6lkrehi 1359 5 total total NN cord-335975-m6lkrehi 1359 6 bilirubin bilirubin NN cord-335975-m6lkrehi 1359 7 was be VBD cord-335975-m6lkrehi 1359 8 lowered lower VBN cord-335975-m6lkrehi 1359 9 in in IN cord-335975-m6lkrehi 1359 10 AoCLF AoCLF NNP cord-335975-m6lkrehi 1359 11 and and CC cord-335975-m6lkrehi 1359 12 post post JJ cord-335975-m6lkrehi 1359 13 - - JJ cord-335975-m6lkrehi 1359 14 surgery surgery JJ cord-335975-m6lkrehi 1359 15 groups group NNS cord-335975-m6lkrehi 1359 16 ( ( -LRB- cord-335975-m6lkrehi 1359 17 p p NN cord-335975-m6lkrehi 1359 18 < < XX cord-335975-m6lkrehi 1359 19 .001 .001 CD cord-335975-m6lkrehi 1359 20 ) ) -RRB- cord-335975-m6lkrehi 1359 21 , , , cord-335975-m6lkrehi 1359 22 also also RB cord-335975-m6lkrehi 1359 23 in in IN cord-335975-m6lkrehi 1359 24 the the DT cord-335975-m6lkrehi 1359 25 ALF ALF NNP cord-335975-m6lkrehi 1359 26 group group NN cord-335975-m6lkrehi 1359 27 although although IN cord-335975-m6lkrehi 1359 28 not not RB cord-335975-m6lkrehi 1359 29 significatively significatively RB cord-335975-m6lkrehi 1359 30 . . . cord-335975-m6lkrehi 1360 1 MELD meld VB cord-335975-m6lkrehi 1360 2 score score NN cord-335975-m6lkrehi 1360 3 was be VBD cord-335975-m6lkrehi 1360 4 lowered lower VBN cord-335975-m6lkrehi 1360 5 in in IN cord-335975-m6lkrehi 1360 6 the the DT cord-335975-m6lkrehi 1360 7 AoCLF AoCLF NNP cord-335975-m6lkrehi 1360 8 and and CC cord-335975-m6lkrehi 1360 9 ALF ALF NNP cord-335975-m6lkrehi 1360 10 group group NN cord-335975-m6lkrehi 1360 11 ( ( -LRB- cord-335975-m6lkrehi 1360 12 p p NN cord-335975-m6lkrehi 1360 13 < < XX cord-335975-m6lkrehi 1360 14 .001 .001 CD cord-335975-m6lkrehi 1360 15 ) ) -RRB- cord-335975-m6lkrehi 1360 16 . . . cord-335975-m6lkrehi 1361 1 However however RB cord-335975-m6lkrehi 1361 2 clinical clinical JJ cord-335975-m6lkrehi 1361 3 variables variable NNS cord-335975-m6lkrehi 1361 4 ( ( -LRB- cord-335975-m6lkrehi 1361 5 Glasgow Glasgow NNP cord-335975-m6lkrehi 1361 6 score score NN cord-335975-m6lkrehi 1361 7 and and CC cord-335975-m6lkrehi 1361 8 encephalopathy encephalopathy NN cord-335975-m6lkrehi 1361 9 ) ) -RRB- cord-335975-m6lkrehi 1361 10 did do VBD cord-335975-m6lkrehi 1361 11 n't not RB cord-335975-m6lkrehi 1361 12 improve improve VB cord-335975-m6lkrehi 1361 13 significatively significatively RB cord-335975-m6lkrehi 1361 14 . . . cord-335975-m6lkrehi 1362 1 In in IN cord-335975-m6lkrehi 1362 2 the the DT cord-335975-m6lkrehi 1362 3 refractory refractory JJ cord-335975-m6lkrehi 1362 4 pruritus pruritus NN cord-335975-m6lkrehi 1362 5 group group NN cord-335975-m6lkrehi 1362 6 , , , cord-335975-m6lkrehi 1362 7 pruritus pruritus NN cord-335975-m6lkrehi 1362 8 decreased decrease VBD cord-335975-m6lkrehi 1362 9 in in IN cord-335975-m6lkrehi 1362 10 20 20 CD cord-335975-m6lkrehi 1362 11 out out IN cord-335975-m6lkrehi 1362 12 of of IN cord-335975-m6lkrehi 1362 13 25 25 CD cord-335975-m6lkrehi 1362 14 patients patient NNS cord-335975-m6lkrehi 1362 15 ( ( -LRB- cord-335975-m6lkrehi 1362 16 p p NN cord-335975-m6lkrehi 1362 17 < < XX cord-335975-m6lkrehi 1362 18 .001 .001 CD cord-335975-m6lkrehi 1362 19 ) ) -RRB- cord-335975-m6lkrehi 1362 20 . . . cord-335975-m6lkrehi 1363 1 Bile bile NN cord-335975-m6lkrehi 1363 2 acid acid NN cord-335975-m6lkrehi 1363 3 levels level NNS cord-335975-m6lkrehi 1363 4 decreased decrease VBD cord-335975-m6lkrehi 1363 5 to to IN cord-335975-m6lkrehi 1363 6 34.8 34.8 CD cord-335975-m6lkrehi 1363 7 % % NN cord-335975-m6lkrehi 1363 8 of of IN cord-335975-m6lkrehi 1363 9 its -PRON- PRP$ cord-335975-m6lkrehi 1363 10 mean mean JJ cord-335975-m6lkrehi 1363 11 baseline baseline JJ cord-335975-m6lkrehi 1363 12 level level NN cord-335975-m6lkrehi 1363 13 ( ( -LRB- cord-335975-m6lkrehi 1363 14 p p NN cord-335975-m6lkrehi 1363 15 < < XX cord-335975-m6lkrehi 1363 16 .001 .001 CD cord-335975-m6lkrehi 1363 17 ) ) -RRB- cord-335975-m6lkrehi 1363 18 . . . cord-335975-m6lkrehi 1364 1 In in IN cord-335975-m6lkrehi 1364 2 the the DT cord-335975-m6lkrehi 1364 3 drug drug NN cord-335975-m6lkrehi 1364 4 intoxication intoxication NN cord-335975-m6lkrehi 1364 5 group group NN cord-335975-m6lkrehi 1364 6 improvement improvement NN cord-335975-m6lkrehi 1364 7 of of IN cord-335975-m6lkrehi 1364 8 the the DT cord-335975-m6lkrehi 1364 9 Richmond Richmond NNP cord-335975-m6lkrehi 1364 10 Agitation Agitation NNP cord-335975-m6lkrehi 1364 11 - - HYPH cord-335975-m6lkrehi 1364 12 Sedation sedation NN cord-335975-m6lkrehi 1364 13 Scale scale NN cord-335975-m6lkrehi 1364 14 ( ( -LRB- cord-335975-m6lkrehi 1364 15 RASS RASS NNP cord-335975-m6lkrehi 1364 16 ) ) -RRB- cord-335975-m6lkrehi 1364 17 from from IN cord-335975-m6lkrehi 1364 18 deeply deeply RB cord-335975-m6lkrehi 1364 19 sedated sedate VBN cord-335975-m6lkrehi 1364 20 ( ( -LRB- cord-335975-m6lkrehi 1364 21 RASS rass XX cord-335975-m6lkrehi 1364 22 < < XX cord-335975-m6lkrehi 1364 23 = = SYM cord-335975-m6lkrehi 1364 24 − − NN cord-335975-m6lkrehi 1364 25 3 3 CD cord-335975-m6lkrehi 1364 26 ) ) -RRB- cord-335975-m6lkrehi 1364 27 to to IN cord-335975-m6lkrehi 1364 28 minimal minimal JJ cord-335975-m6lkrehi 1364 29 sedation sedation NN cord-335975-m6lkrehi 1364 30 ( ( -LRB- cord-335975-m6lkrehi 1364 31 RASS RASS NNP cord-335975-m6lkrehi 1364 32 > > XX cord-335975-m6lkrehi 1364 33 = = NFP cord-335975-m6lkrehi 1364 34 − − CD cord-335975-m6lkrehi 1364 35 2 2 CD cord-335975-m6lkrehi 1364 36 ) ) -RRB- cord-335975-m6lkrehi 1364 37 was be VBD cord-335975-m6lkrehi 1364 38 obtained obtain VBN cord-335975-m6lkrehi 1364 39 in in IN cord-335975-m6lkrehi 1364 40 5 5 CD cord-335975-m6lkrehi 1364 41 out out IN cord-335975-m6lkrehi 1364 42 of of IN cord-335975-m6lkrehi 1364 43 6 6 CD cord-335975-m6lkrehi 1364 44 patients patient NNS cord-335975-m6lkrehi 1364 45 . . . cord-335975-m6lkrehi 1365 1 Out out IN cord-335975-m6lkrehi 1365 2 of of IN cord-335975-m6lkrehi 1365 3 300 300 CD cord-335975-m6lkrehi 1365 4 sessions session NNS cord-335975-m6lkrehi 1365 5 , , , cord-335975-m6lkrehi 1365 6 catheter catheter NN cord-335975-m6lkrehi 1365 7 - - HYPH cord-335975-m6lkrehi 1365 8 related relate VBN cord-335975-m6lkrehi 1365 9 adverse adverse JJ cord-335975-m6lkrehi 1365 10 effects effect NNS cord-335975-m6lkrehi 1365 11 were be VBD cord-335975-m6lkrehi 1365 12 low low JJ cord-335975-m6lkrehi 1365 13 ( ( -LRB- cord-335975-m6lkrehi 1365 14 1.3 1.3 CD cord-335975-m6lkrehi 1365 15 % % NN cord-335975-m6lkrehi 1365 16 ) ) -RRB- cord-335975-m6lkrehi 1365 17 , , , cord-335975-m6lkrehi 1365 18 thrombocytopenia thrombocytopenia NN cord-335975-m6lkrehi 1365 19 was be VBD cord-335975-m6lkrehi 1365 20 the the DT cord-335975-m6lkrehi 1365 21 main main JJ cord-335975-m6lkrehi 1365 22 adverse adverse JJ cord-335975-m6lkrehi 1365 23 effect effect NN cord-335975-m6lkrehi 1365 24 ( ( -LRB- cord-335975-m6lkrehi 1365 25 26.7 26.7 CD cord-335975-m6lkrehi 1365 26 % % NN cord-335975-m6lkrehi 1365 27 ) ) -RRB- cord-335975-m6lkrehi 1365 28 . . . cord-335975-m6lkrehi 1366 1 Conclusion conclusion NN cord-335975-m6lkrehi 1366 2 : : : cord-335975-m6lkrehi 1367 1 We -PRON- PRP cord-335975-m6lkrehi 1367 2 report report VBP cord-335975-m6lkrehi 1367 3 our -PRON- PRP$ cord-335975-m6lkrehi 1367 4 MARS MARS NNP cord-335975-m6lkrehi 1368 1 ® ® JJ cord-335975-m6lkrehi 1368 2 experience experience NN cord-335975-m6lkrehi 1368 3 with with IN cord-335975-m6lkrehi 1368 4 the the DT cord-335975-m6lkrehi 1368 5 largest large JJS cord-335975-m6lkrehi 1368 6 cohort cohort NN cord-335975-m6lkrehi 1368 7 of of IN cord-335975-m6lkrehi 1368 8 patients patient NNS cord-335975-m6lkrehi 1368 9 referred refer VBN cord-335975-m6lkrehi 1368 10 from from IN cord-335975-m6lkrehi 1368 11 a a DT cord-335975-m6lkrehi 1368 12 single single JJ cord-335975-m6lkrehi 1368 13 hospital hospital NN cord-335975-m6lkrehi 1368 14 . . . cord-335975-m6lkrehi 1369 1 We -PRON- PRP cord-335975-m6lkrehi 1369 2 showed show VBD cord-335975-m6lkrehi 1369 3 biological biological JJ cord-335975-m6lkrehi 1369 4 efficacy efficacy NN cord-335975-m6lkrehi 1369 5 in in IN cord-335975-m6lkrehi 1369 6 all all DT cord-335975-m6lkrehi 1369 7 5 5 CD cord-335975-m6lkrehi 1369 8 indications indication NNS cord-335975-m6lkrehi 1369 9 , , , cord-335975-m6lkrehi 1369 10 although although IN cord-335975-m6lkrehi 1369 11 clinical clinical JJ cord-335975-m6lkrehi 1369 12 efficacy efficacy NN cord-335975-m6lkrehi 1369 13 was be VBD cord-335975-m6lkrehi 1369 14 uneven uneven JJ cord-335975-m6lkrehi 1369 15 . . . cord-335975-m6lkrehi 1370 1 MARS MARS NNP cord-335975-m6lkrehi 1371 1 ® ® , cord-335975-m6lkrehi 1371 2 therapy therapy NN cord-335975-m6lkrehi 1371 3 in in IN cord-335975-m6lkrehi 1371 4 patients patient NNS cord-335975-m6lkrehi 1371 5 with with IN cord-335975-m6lkrehi 1371 6 refractory refractory JJ cord-335975-m6lkrehi 1371 7 pruritus pruritus NN cord-335975-m6lkrehi 1371 8 yielded yield VBD cord-335975-m6lkrehi 1371 9 promising promising JJ cord-335975-m6lkrehi 1371 10 results result NNS cord-335975-m6lkrehi 1371 11 . . . cord-335975-m6lkrehi 1372 1 Tolerance tolerance NN cord-335975-m6lkrehi 1372 2 was be VBD cord-335975-m6lkrehi 1372 3 good good JJ cord-335975-m6lkrehi 1372 4 and and CC cord-335975-m6lkrehi 1372 5 the the DT cord-335975-m6lkrehi 1372 6 main main JJ cord-335975-m6lkrehi 1372 7 adverse adverse JJ cord-335975-m6lkrehi 1372 8 effect effect NN cord-335975-m6lkrehi 1372 9 was be VBD cord-335975-m6lkrehi 1372 10 thrombocytopenia thrombocytopenia JJ cord-335975-m6lkrehi 1372 11 . . . cord-335975-m6lkrehi 1373 1 Global global JJ cord-335975-m6lkrehi 1373 2 transplantation transplantation NN cord-335975-m6lkrehi 1373 3 - - HYPH cord-335975-m6lkrehi 1373 4 free free JJ cord-335975-m6lkrehi 1373 5 survival survival NN cord-335975-m6lkrehi 1373 6 was be VBD cord-335975-m6lkrehi 1373 7 low low JJ cord-335975-m6lkrehi 1373 8 in in IN cord-335975-m6lkrehi 1373 9 patients patient NNS cord-335975-m6lkrehi 1373 10 with with IN cord-335975-m6lkrehi 1373 11 liver liver NN cord-335975-m6lkrehi 1373 12 failure failure NN cord-335975-m6lkrehi 1373 13 , , , cord-335975-m6lkrehi 1373 14 reinforcing reinforce VBG cord-335975-m6lkrehi 1373 15 the the DT cord-335975-m6lkrehi 1373 16 need need NN cord-335975-m6lkrehi 1373 17 for for IN cord-335975-m6lkrehi 1373 18 a a DT cord-335975-m6lkrehi 1373 19 liver liver NN cord-335975-m6lkrehi 1373 20 transplantation transplantation NN cord-335975-m6lkrehi 1373 21 center center NN cord-335975-m6lkrehi 1373 22 when when WRB cord-335975-m6lkrehi 1373 23 using use VBG cord-335975-m6lkrehi 1373 24 MARS MARS NNP cord-335975-m6lkrehi 1373 25 ® ® NNP cord-335975-m6lkrehi 1373 26 . . . cord-335975-m6lkrehi 1374 1 Introduction introduction NN cord-335975-m6lkrehi 1374 2 : : : cord-335975-m6lkrehi 1375 1 Colonoscopy Colonoscopy NNP cord-335975-m6lkrehi 1375 2 is be VBZ cord-335975-m6lkrehi 1375 3 crucial crucial JJ cord-335975-m6lkrehi 1375 4 for for IN cord-335975-m6lkrehi 1375 5 the the DT cord-335975-m6lkrehi 1375 6 management management NN cord-335975-m6lkrehi 1375 7 of of IN cord-335975-m6lkrehi 1375 8 lower low JJR cord-335975-m6lkrehi 1375 9 gastro gastro JJ cord-335975-m6lkrehi 1375 10 - - JJ cord-335975-m6lkrehi 1375 11 intestinal intestinal JJ cord-335975-m6lkrehi 1375 12 disorders disorder NNS cord-335975-m6lkrehi 1375 13 , , , cord-335975-m6lkrehi 1375 14 but but CC cord-335975-m6lkrehi 1375 15 its -PRON- PRP$ cord-335975-m6lkrehi 1375 16 profitability profitability NN cord-335975-m6lkrehi 1375 17 is be VBZ cord-335975-m6lkrehi 1375 18 discussed discuss VBN cord-335975-m6lkrehi 1375 19 in in IN cord-335975-m6lkrehi 1375 20 critically critically RB cord-335975-m6lkrehi 1375 21 ill ill JJ cord-335975-m6lkrehi 1375 22 patients patient NNS cord-335975-m6lkrehi 1375 23 , , , cord-335975-m6lkrehi 1375 24 mainly mainly RB cord-335975-m6lkrehi 1375 25 because because IN cord-335975-m6lkrehi 1375 26 of of IN cord-335975-m6lkrehi 1375 27 the the DT cord-335975-m6lkrehi 1375 28 complexity complexity NN cord-335975-m6lkrehi 1375 29 of of IN cord-335975-m6lkrehi 1375 30 colonic colonic JJ cord-335975-m6lkrehi 1375 31 preparation preparation NN cord-335975-m6lkrehi 1375 32 . . . cord-335975-m6lkrehi 1376 1 As as IN cord-335975-m6lkrehi 1376 2 the the DT cord-335975-m6lkrehi 1376 3 profitability profitability NN cord-335975-m6lkrehi 1376 4 of of IN cord-335975-m6lkrehi 1376 5 colonoscopy colonoscopy NN cord-335975-m6lkrehi 1376 6 in in IN cord-335975-m6lkrehi 1376 7 Intermediate Intermediate NNP cord-335975-m6lkrehi 1376 8 or or CC cord-335975-m6lkrehi 1376 9 Intensive Intensive NNP cord-335975-m6lkrehi 1376 10 Care Care NNP cord-335975-m6lkrehi 1376 11 Units Units NNPS cord-335975-m6lkrehi 1376 12 ( ( -LRB- cord-335975-m6lkrehi 1376 13 CICU CICU NNP cord-335975-m6lkrehi 1376 14 ) ) -RRB- cord-335975-m6lkrehi 1376 15 has have VBZ cord-335975-m6lkrehi 1376 16 been be VBN cord-335975-m6lkrehi 1376 17 scarcely scarcely RB cord-335975-m6lkrehi 1376 18 reported report VBN cord-335975-m6lkrehi 1376 19 ( ( -LRB- cord-335975-m6lkrehi 1376 20 1 1 CD cord-335975-m6lkrehi 1376 21 ) ) -RRB- cord-335975-m6lkrehi 1376 22 , , , cord-335975-m6lkrehi 1376 23 we -PRON- PRP cord-335975-m6lkrehi 1376 24 investigated investigate VBD cord-335975-m6lkrehi 1376 25 its -PRON- PRP$ cord-335975-m6lkrehi 1376 26 indications indication NNS cord-335975-m6lkrehi 1376 27 and and CC cord-335975-m6lkrehi 1376 28 usefulness usefulness NN cord-335975-m6lkrehi 1376 29 . . . cord-335975-m6lkrehi 1377 1 Patients patient NNS cord-335975-m6lkrehi 1377 2 and and CC cord-335975-m6lkrehi 1377 3 methods method NNS cord-335975-m6lkrehi 1377 4 : : : cord-335975-m6lkrehi 1377 5 Retrospective retrospective JJ cord-335975-m6lkrehi 1377 6 bicenter bicenter NNP cord-335975-m6lkrehi 1377 7 observational observational JJ cord-335975-m6lkrehi 1377 8 study study NN cord-335975-m6lkrehi 1377 9 ( ( -LRB- cord-335975-m6lkrehi 1377 10 2004 2004 CD cord-335975-m6lkrehi 1377 11 ) ) -RRB- cord-335975-m6lkrehi 1377 12 ( ( -LRB- cord-335975-m6lkrehi 1377 13 2005 2005 CD cord-335975-m6lkrehi 1377 14 ) ) -RRB- cord-335975-m6lkrehi 1377 15 ( ( -LRB- cord-335975-m6lkrehi 1377 16 2006 2006 CD cord-335975-m6lkrehi 1377 17 ) ) -RRB- cord-335975-m6lkrehi 1377 18 ( ( -LRB- cord-335975-m6lkrehi 1377 19 2007 2007 CD cord-335975-m6lkrehi 1377 20 ) ) -RRB- cord-335975-m6lkrehi 1377 21 ( ( -LRB- cord-335975-m6lkrehi 1377 22 2008 2008 CD cord-335975-m6lkrehi 1377 23 ) ) -RRB- cord-335975-m6lkrehi 1377 24 ( ( -LRB- cord-335975-m6lkrehi 1377 25 2009 2009 CD cord-335975-m6lkrehi 1377 26 ) ) -RRB- cord-335975-m6lkrehi 1377 27 ( ( -LRB- cord-335975-m6lkrehi 1377 28 2010 2010 CD cord-335975-m6lkrehi 1377 29 ) ) -RRB- cord-335975-m6lkrehi 1377 30 ( ( -LRB- cord-335975-m6lkrehi 1377 31 2011 2011 CD cord-335975-m6lkrehi 1377 32 ) ) -RRB- cord-335975-m6lkrehi 1377 33 ( ( -LRB- cord-335975-m6lkrehi 1377 34 2012 2012 CD cord-335975-m6lkrehi 1377 35 ) ) -RRB- cord-335975-m6lkrehi 1378 1 ( ( -LRB- cord-335975-m6lkrehi 1378 2 2013 2013 CD cord-335975-m6lkrehi 1378 3 ) ) -RRB- cord-335975-m6lkrehi 1379 1 ( ( -LRB- cord-335975-m6lkrehi 1379 2 2014 2014 CD cord-335975-m6lkrehi 1379 3 ) ) -RRB- cord-335975-m6lkrehi 1379 4 ( ( -LRB- cord-335975-m6lkrehi 1379 5 2015 2015 CD cord-335975-m6lkrehi 1379 6 ) ) -RRB- cord-335975-m6lkrehi 1379 7 . . . cord-335975-m6lkrehi 1380 1 Main main JJ cord-335975-m6lkrehi 1380 2 endpoint endpoint NN cord-335975-m6lkrehi 1380 3 : : : cord-335975-m6lkrehi 1380 4 diagnostic diagnostic JJ cord-335975-m6lkrehi 1380 5 profitability profitability NN cord-335975-m6lkrehi 1380 6 of of IN cord-335975-m6lkrehi 1380 7 CICU CICU NNP cord-335975-m6lkrehi 1380 8 in in IN cord-335975-m6lkrehi 1380 9 unselected unselected JJ cord-335975-m6lkrehi 1380 10 critically critically RB cord-335975-m6lkrehi 1380 11 ill ill JJ cord-335975-m6lkrehi 1380 12 patients patient NNS cord-335975-m6lkrehi 1380 13 . . . cord-335975-m6lkrehi 1381 1 Profitability profitability NN cord-335975-m6lkrehi 1381 2 was be VBD cord-335975-m6lkrehi 1381 3 a a DT cord-335975-m6lkrehi 1381 4 priori priori FW cord-335975-m6lkrehi 1381 5 defined define VBN cord-335975-m6lkrehi 1381 6 as as IN cord-335975-m6lkrehi 1381 7 " " `` cord-335975-m6lkrehi 1381 8 high high JJ cord-335975-m6lkrehi 1381 9 " " '' cord-335975-m6lkrehi 1381 10 if if IN cord-335975-m6lkrehi 1381 11 CICU CICU NNP cord-335975-m6lkrehi 1381 12 led lead VBD cord-335975-m6lkrehi 1381 13 to to TO cord-335975-m6lkrehi 1381 14 adapt adapt VB cord-335975-m6lkrehi 1381 15 ongoing ongoing JJ cord-335975-m6lkrehi 1381 16 therapies therapy NNS cord-335975-m6lkrehi 1381 17 ; ; , cord-335975-m6lkrehi 1381 18 allowed allow VBD cord-335975-m6lkrehi 1381 19 an an DT cord-335975-m6lkrehi 1381 20 endoscopic endoscopic JJ cord-335975-m6lkrehi 1381 21 intervention intervention NN cord-335975-m6lkrehi 1381 22 ; ; , cord-335975-m6lkrehi 1381 23 or or CC cord-335975-m6lkrehi 1381 24 participated participate VBD cord-335975-m6lkrehi 1381 25 in in IN cord-335975-m6lkrehi 1381 26 the the DT cord-335975-m6lkrehi 1381 27 decision decision NN cord-335975-m6lkrehi 1381 28 to to TO cord-335975-m6lkrehi 1381 29 limit limit VB cord-335975-m6lkrehi 1381 30 therapeutic therapeutic JJ cord-335975-m6lkrehi 1381 31 effort effort NN cord-335975-m6lkrehi 1381 32 . . . cord-335975-m6lkrehi 1382 1 Secondary secondary JJ cord-335975-m6lkrehi 1382 2 endpoints endpoint NNS cord-335975-m6lkrehi 1382 3 : : : cord-335975-m6lkrehi 1382 4 describe describe VB cord-335975-m6lkrehi 1382 5 the the DT cord-335975-m6lkrehi 1382 6 quality quality NN cord-335975-m6lkrehi 1382 7 of of IN cord-335975-m6lkrehi 1382 8 CICU CICU NNP cord-335975-m6lkrehi 1382 9 and and CC cord-335975-m6lkrehi 1382 10 its -PRON- PRP$ cord-335975-m6lkrehi 1382 11 preparation preparation NN cord-335975-m6lkrehi 1382 12 ; ; : cord-335975-m6lkrehi 1382 13 determine determine VB cord-335975-m6lkrehi 1382 14 its -PRON- PRP$ cord-335975-m6lkrehi 1382 15 position position NN cord-335975-m6lkrehi 1382 16 in in IN cord-335975-m6lkrehi 1382 17 diagnosis diagnosis NN cord-335975-m6lkrehi 1382 18 strategy strategy NN cord-335975-m6lkrehi 1382 19 ; ; : cord-335975-m6lkrehi 1382 20 describe describe VB cord-335975-m6lkrehi 1382 21 its -PRON- PRP$ cord-335975-m6lkrehi 1382 22 morbidity morbidity NN cord-335975-m6lkrehi 1382 23 . . . cord-335975-m6lkrehi 1382 24 ) ) -RRB- cord-335975-m6lkrehi 1383 1 + + CC cord-335975-m6lkrehi 1383 2 investigation investigation NN cord-335975-m6lkrehi 1383 3 of of IN cord-335975-m6lkrehi 1383 4 a a DT cord-335975-m6lkrehi 1383 5 Gram Gram NNP cord-335975-m6lkrehi 1383 6 negative negative JJ cord-335975-m6lkrehi 1383 7 bacilli bacilli NN cord-335975-m6lkrehi 1383 8 sepsis sepsis NN cord-335975-m6lkrehi 1383 9 ( ( -LRB- cord-335975-m6lkrehi 1383 10 n n NN cord-335975-m6lkrehi 1383 11 = = SYM cord-335975-m6lkrehi 1383 12 7 7 CD cord-335975-m6lkrehi 1383 13 , , , cord-335975-m6lkrehi 1383 14 6 6 CD cord-335975-m6lkrehi 1383 15 % % NN cord-335975-m6lkrehi 1383 16 ) ) -RRB- cord-335975-m6lkrehi 1383 17 + + CC cord-335975-m6lkrehi 1383 18 sigmoid sigmoid JJ cord-335975-m6lkrehi 1383 19 volvulus volvulus NN cord-335975-m6lkrehi 1383 20 ( ( -LRB- cord-335975-m6lkrehi 1383 21 n n NN cord-335975-m6lkrehi 1383 22 = = SYM cord-335975-m6lkrehi 1383 23 4 4 CD cord-335975-m6lkrehi 1383 24 , , , cord-335975-m6lkrehi 1383 25 4 4 CD cord-335975-m6lkrehi 1383 26 % % NN cord-335975-m6lkrehi 1383 27 ) ) -RRB- cord-335975-m6lkrehi 1383 28 + + CC cord-335975-m6lkrehi 1383 29 and and CC cord-335975-m6lkrehi 1383 30 cancer cancer NN cord-335975-m6lkrehi 1383 31 diagnosis diagnosis NN cord-335975-m6lkrehi 1383 32 ( ( -LRB- cord-335975-m6lkrehi 1383 33 n n NN cord-335975-m6lkrehi 1383 34 = = SYM cord-335975-m6lkrehi 1383 35 4 4 CD cord-335975-m6lkrehi 1383 36 + + SYM cord-335975-m6lkrehi 1383 37 4 4 CD cord-335975-m6lkrehi 1383 38 % % NN cord-335975-m6lkrehi 1383 39 ) ) -RRB- cord-335975-m6lkrehi 1383 40 . . . cord-335975-m6lkrehi 1384 1 CICU CICU NNP cord-335975-m6lkrehi 1384 2 profitability profitability NN cord-335975-m6lkrehi 1384 3 was be VBD cord-335975-m6lkrehi 1384 4 deemed deem VBN cord-335975-m6lkrehi 1384 5 high high JJ cord-335975-m6lkrehi 1384 6 in in IN cord-335975-m6lkrehi 1384 7 50 50 CD cord-335975-m6lkrehi 1384 8 % % NN cord-335975-m6lkrehi 1384 9 ( ( -LRB- cord-335975-m6lkrehi 1384 10 n n NN cord-335975-m6lkrehi 1384 11 = = SYM cord-335975-m6lkrehi 1384 12 56 56 CD cord-335975-m6lkrehi 1384 13 ) ) -RRB- cord-335975-m6lkrehi 1384 14 , , , cord-335975-m6lkrehi 1384 15 with with IN cord-335975-m6lkrehi 1384 16 an an DT cord-335975-m6lkrehi 1384 17 endoscopic endoscopic JJ cord-335975-m6lkrehi 1384 18 intervention intervention NN cord-335975-m6lkrehi 1384 19 performed perform VBN cord-335975-m6lkrehi 1384 20 in in IN cord-335975-m6lkrehi 1384 21 32 32 CD cord-335975-m6lkrehi 1384 22 % % NN cord-335975-m6lkrehi 1384 23 ( ( -LRB- cord-335975-m6lkrehi 1384 24 n n NN cord-335975-m6lkrehi 1384 25 = = SYM cord-335975-m6lkrehi 1384 26 35 35 CD cord-335975-m6lkrehi 1384 27 ) ) -RRB- cord-335975-m6lkrehi 1384 28 . . . cord-335975-m6lkrehi 1385 1 The the DT cord-335975-m6lkrehi 1385 2 CICU CICU NNP cord-335975-m6lkrehi 1385 3 lead lead NN cord-335975-m6lkrehi 1385 4 to to IN cord-335975-m6lkrehi 1385 5 antimicrobial antimicrobial JJ cord-335975-m6lkrehi 1385 6 adaptation adaptation NN cord-335975-m6lkrehi 1385 7 ( ( -LRB- cord-335975-m6lkrehi 1385 8 n n NN cord-335975-m6lkrehi 1385 9 = = SYM cord-335975-m6lkrehi 1385 10 9 9 CD cord-335975-m6lkrehi 1385 11 ) ) -RRB- cord-335975-m6lkrehi 1385 12 , , , cord-335975-m6lkrehi 1385 13 emergent emergent JJ cord-335975-m6lkrehi 1385 14 surgery surgery NN cord-335975-m6lkrehi 1385 15 ( ( -LRB- cord-335975-m6lkrehi 1385 16 n n NN cord-335975-m6lkrehi 1385 17 = = SYM cord-335975-m6lkrehi 1385 18 10 10 CD cord-335975-m6lkrehi 1385 19 ) ) -RRB- cord-335975-m6lkrehi 1385 20 , , , cord-335975-m6lkrehi 1385 21 or or CC cord-335975-m6lkrehi 1385 22 to to TO cord-335975-m6lkrehi 1385 23 limit limit VB cord-335975-m6lkrehi 1385 24 therapeutics therapeutic NNS cord-335975-m6lkrehi 1385 25 effort effort NN cord-335975-m6lkrehi 1385 26 ( ( -LRB- cord-335975-m6lkrehi 1385 27 n n NN cord-335975-m6lkrehi 1385 28 = = SYM cord-335975-m6lkrehi 1385 29 2 2 CD cord-335975-m6lkrehi 1385 30 ) ) -RRB- cord-335975-m6lkrehi 1385 31 . . . cord-335975-m6lkrehi 1386 1 In in IN cord-335975-m6lkrehi 1386 2 23 23 CD cord-335975-m6lkrehi 1386 3 cases case NNS cord-335975-m6lkrehi 1386 4 ( ( -LRB- cord-335975-m6lkrehi 1386 5 21 21 CD cord-335975-m6lkrehi 1386 6 % % NN cord-335975-m6lkrehi 1386 7 ) ) -RRB- cord-335975-m6lkrehi 1386 8 the the DT cord-335975-m6lkrehi 1386 9 CICU CICU NNP cord-335975-m6lkrehi 1386 10 was be VBD cord-335975-m6lkrehi 1386 11 considered consider VBN cord-335975-m6lkrehi 1386 12 normal normal JJ cord-335975-m6lkrehi 1386 13 . . . cord-335975-m6lkrehi 1387 1 Patients patient NNS cord-335975-m6lkrehi 1387 2 ' ' POS cord-335975-m6lkrehi 1387 3 preparation preparation NN cord-335975-m6lkrehi 1387 4 was be VBD cord-335975-m6lkrehi 1387 5 rated rate VBN cord-335975-m6lkrehi 1387 6 as as IN cord-335975-m6lkrehi 1387 7 good good JJ cord-335975-m6lkrehi 1387 8 in in IN cord-335975-m6lkrehi 1387 9 27 27 CD cord-335975-m6lkrehi 1387 10 % % NN cord-335975-m6lkrehi 1387 11 ( ( -LRB- cord-335975-m6lkrehi 1387 12 n n NN cord-335975-m6lkrehi 1387 13 = = SYM cord-335975-m6lkrehi 1387 14 30 30 CD cord-335975-m6lkrehi 1387 15 ) ) -RRB- cord-335975-m6lkrehi 1387 16 + + CC cord-335975-m6lkrehi 1387 17 and and CC cord-335975-m6lkrehi 1387 18 the the DT cord-335975-m6lkrehi 1387 19 colonoscopy colonoscopy NN cord-335975-m6lkrehi 1387 20 was be VBD cord-335975-m6lkrehi 1387 21 complete complete JJ cord-335975-m6lkrehi 1387 22 in in IN cord-335975-m6lkrehi 1387 23 33 33 CD cord-335975-m6lkrehi 1387 24 ( ( -LRB- cord-335975-m6lkrehi 1387 25 30 30 CD cord-335975-m6lkrehi 1387 26 % % NN cord-335975-m6lkrehi 1387 27 ) ) -RRB- cord-335975-m6lkrehi 1387 28 . . . cord-335975-m6lkrehi 1388 1 The the DT cord-335975-m6lkrehi 1388 2 CICU CICU NNP cord-335975-m6lkrehi 1388 3 was be VBD cord-335975-m6lkrehi 1388 4 mainly mainly RB cord-335975-m6lkrehi 1388 5 performed perform VBN cord-335975-m6lkrehi 1388 6 as as IN cord-335975-m6lkrehi 1388 7 a a DT cord-335975-m6lkrehi 1388 8 2nd 2nd NN cord-335975-m6lkrehi 1388 9 ( ( -LRB- cord-335975-m6lkrehi 1388 10 58 58 CD cord-335975-m6lkrehi 1388 11 % % NN cord-335975-m6lkrehi 1388 12 ) ) -RRB- cord-335975-m6lkrehi 1388 13 or or CC cord-335975-m6lkrehi 1388 14 3rd 3rd NN cord-335975-m6lkrehi 1388 15 ( ( -LRB- cord-335975-m6lkrehi 1388 16 40 40 CD cord-335975-m6lkrehi 1388 17 % % NN cord-335975-m6lkrehi 1388 18 ) ) -RRB- cord-335975-m6lkrehi 1388 19 investigation investigation NN cord-335975-m6lkrehi 1388 20 after after IN cord-335975-m6lkrehi 1388 21 an an DT cord-335975-m6lkrehi 1388 22 abdominal abdominal JJ cord-335975-m6lkrehi 1388 23 CT ct NN cord-335975-m6lkrehi 1388 24 - - NN cord-335975-m6lkrehi 1388 25 scan scan NN cord-335975-m6lkrehi 1388 26 or or CC cord-335975-m6lkrehi 1388 27 an an DT cord-335975-m6lkrehi 1388 28 upper upper JJ cord-335975-m6lkrehi 1388 29 digestive digestive JJ cord-335975-m6lkrehi 1388 30 endoscopy endoscopy NN cord-335975-m6lkrehi 1388 31 ( ( -LRB- cord-335975-m6lkrehi 1388 32 respectively respectively RB cord-335975-m6lkrehi 1388 33 performed perform VBN cord-335975-m6lkrehi 1388 34 in in IN cord-335975-m6lkrehi 1388 35 first first JJ cord-335975-m6lkrehi 1388 36 instance instance NN cord-335975-m6lkrehi 1388 37 in in IN cord-335975-m6lkrehi 1388 38 69 69 CD cord-335975-m6lkrehi 1388 39 and and CC cord-335975-m6lkrehi 1388 40 55 55 CD cord-335975-m6lkrehi 1388 41 % % NN cord-335975-m6lkrehi 1388 42 ) ) -RRB- cord-335975-m6lkrehi 1388 43 . . . cord-335975-m6lkrehi 1389 1 Three three CD cord-335975-m6lkrehi 1389 2 CICU CICU NNP cord-335975-m6lkrehi 1389 3 were be VBD cord-335975-m6lkrehi 1389 4 complicated complicate VBN cord-335975-m6lkrehi 1389 5 by by IN cord-335975-m6lkrehi 1389 6 3 3 CD cord-335975-m6lkrehi 1389 7 hemodynamic hemodynamic JJ cord-335975-m6lkrehi 1389 8 and and CC cord-335975-m6lkrehi 1389 9 2 2 CD cord-335975-m6lkrehi 1389 10 respiratory respiratory JJ cord-335975-m6lkrehi 1389 11 failures failure NNS cord-335975-m6lkrehi 1389 12 , , , cord-335975-m6lkrehi 1389 13 none none NN cord-335975-m6lkrehi 1389 14 were be VBD cord-335975-m6lkrehi 1389 15 fatal fatal JJ cord-335975-m6lkrehi 1389 16 . . . cord-335975-m6lkrehi 1390 1 Discussion discussion NN cord-335975-m6lkrehi 1390 2 : : : cord-335975-m6lkrehi 1391 1 In in IN cord-335975-m6lkrehi 1391 2 our -PRON- PRP$ cord-335975-m6lkrehi 1391 3 series series NN cord-335975-m6lkrehi 1391 4 of of IN cord-335975-m6lkrehi 1391 5 unselected unselected JJ cord-335975-m6lkrehi 1391 6 critically critically RB cord-335975-m6lkrehi 1391 7 ill ill JJ cord-335975-m6lkrehi 1391 8 patients patient NNS cord-335975-m6lkrehi 1391 9 , , , cord-335975-m6lkrehi 1391 10 CICU CICU NNP cord-335975-m6lkrehi 1391 11 were be VBD cord-335975-m6lkrehi 1391 12 mainly mainly RB cord-335975-m6lkrehi 1391 13 performed perform VBN cord-335975-m6lkrehi 1391 14 to to TO cord-335975-m6lkrehi 1391 15 investigate investigate VB cord-335975-m6lkrehi 1391 16 lower low JJR cord-335975-m6lkrehi 1391 17 gastro gastro JJ cord-335975-m6lkrehi 1391 18 - - JJ cord-335975-m6lkrehi 1391 19 intestinal intestinal JJ cord-335975-m6lkrehi 1391 20 bleeding bleeding NN cord-335975-m6lkrehi 1391 21 . . . cord-335975-m6lkrehi 1392 1 Despite despite IN cord-335975-m6lkrehi 1392 2 a a DT cord-335975-m6lkrehi 1392 3 low low JJ cord-335975-m6lkrehi 1392 4 rate rate NN cord-335975-m6lkrehi 1392 5 of of IN cord-335975-m6lkrehi 1392 6 good good JJ cord-335975-m6lkrehi 1392 7 preparation preparation NN cord-335975-m6lkrehi 1392 8 , , , cord-335975-m6lkrehi 1392 9 CICU CICU NNP cord-335975-m6lkrehi 1392 10 is be VBZ cord-335975-m6lkrehi 1392 11 safe safe JJ cord-335975-m6lkrehi 1392 12 and and CC cord-335975-m6lkrehi 1392 13 its -PRON- PRP$ cord-335975-m6lkrehi 1392 14 profitability profitability NN cord-335975-m6lkrehi 1392 15 is be VBZ cord-335975-m6lkrehi 1392 16 high high JJ cord-335975-m6lkrehi 1392 17 in in IN cord-335975-m6lkrehi 1392 18 the the DT cord-335975-m6lkrehi 1392 19 majority majority NN cord-335975-m6lkrehi 1392 20 of of IN cord-335975-m6lkrehi 1392 21 cases case NNS cord-335975-m6lkrehi 1392 22 . . . cord-335975-m6lkrehi 1393 1 Conclusion conclusion NN cord-335975-m6lkrehi 1393 2 : : : cord-335975-m6lkrehi 1394 1 Although although IN cord-335975-m6lkrehi 1394 2 performed perform VBN cord-335975-m6lkrehi 1394 3 in in IN cord-335975-m6lkrehi 1394 4 poor poor JJ cord-335975-m6lkrehi 1394 5 conditions condition NNS cord-335975-m6lkrehi 1394 6 , , , cord-335975-m6lkrehi 1394 7 CICU CICU NNP cord-335975-m6lkrehi 1394 8 seems seem VBZ cord-335975-m6lkrehi 1394 9 useful useful JJ cord-335975-m6lkrehi 1394 10 in in IN cord-335975-m6lkrehi 1394 11 the the DT cord-335975-m6lkrehi 1394 12 diagnostic diagnostic JJ cord-335975-m6lkrehi 1394 13 and and CC cord-335975-m6lkrehi 1394 14 the the DT cord-335975-m6lkrehi 1394 15 therapeutic therapeutic JJ cord-335975-m6lkrehi 1394 16 management management NN cord-335975-m6lkrehi 1394 17 of of IN cord-335975-m6lkrehi 1394 18 critically critically RB cord-335975-m6lkrehi 1394 19 ill ill JJ cord-335975-m6lkrehi 1394 20 patients patient NNS cord-335975-m6lkrehi 1394 21 , , , cord-335975-m6lkrehi 1394 22 and and CC cord-335975-m6lkrehi 1394 23 not not RB cord-335975-m6lkrehi 1394 24 only only RB cord-335975-m6lkrehi 1394 25 in in IN cord-335975-m6lkrehi 1394 26 gastro gastro JJ cord-335975-m6lkrehi 1394 27 - - JJ cord-335975-m6lkrehi 1394 28 intestinal intestinal JJ cord-335975-m6lkrehi 1394 29 bleeding bleeding NN cord-335975-m6lkrehi 1394 30 . . . cord-335975-m6lkrehi 1395 1 ( ( -LRB- cord-335975-m6lkrehi 1395 2 1 1 LS cord-335975-m6lkrehi 1395 3 ) ) -RRB- cord-335975-m6lkrehi 1395 4 Church church NN cord-335975-m6lkrehi 1395 5 , , , cord-335975-m6lkrehi 1395 6 Surgical surgical JJ cord-335975-m6lkrehi 1395 7 endoscopy endoscopy NN cord-335975-m6lkrehi 1395 8 2014 2014 CD cord-335975-m6lkrehi 1395 9 . . . cord-335975-m6lkrehi 1396 1 Introduction introduction NN cord-335975-m6lkrehi 1396 2 : : : cord-335975-m6lkrehi 1396 3 Accurate accurate JJ cord-335975-m6lkrehi 1396 4 pain pain NN cord-335975-m6lkrehi 1396 5 assessment assessment NN cord-335975-m6lkrehi 1396 6 is be VBZ cord-335975-m6lkrehi 1396 7 associated associate VBN cord-335975-m6lkrehi 1396 8 with with IN cord-335975-m6lkrehi 1396 9 better well JJR cord-335975-m6lkrehi 1396 10 outcomes outcome NNS cord-335975-m6lkrehi 1396 11 in in IN cord-335975-m6lkrehi 1396 12 intensive intensive JJ cord-335975-m6lkrehi 1396 13 care care NN cord-335975-m6lkrehi 1396 14 unit unit NN cord-335975-m6lkrehi 1396 15 ( ( -LRB- cord-335975-m6lkrehi 1396 16 ICU ICU NNP cord-335975-m6lkrehi 1396 17 ) ) -RRB- cord-335975-m6lkrehi 1396 18 patients patient NNS cord-335975-m6lkrehi 1396 19 . . . cord-335975-m6lkrehi 1397 1 Specific specific JJ cord-335975-m6lkrehi 1397 2 scales scale NNS cord-335975-m6lkrehi 1397 3 for for IN cord-335975-m6lkrehi 1397 4 noncommunicative noncommunicative JJ cord-335975-m6lkrehi 1397 5 patients patient NNS cord-335975-m6lkrehi 1397 6 have have VBP cord-335975-m6lkrehi 1397 7 been be VBN cord-335975-m6lkrehi 1397 8 developed develop VBN cord-335975-m6lkrehi 1397 9 and and CC cord-335975-m6lkrehi 1397 10 validated validate VBN cord-335975-m6lkrehi 1397 11 but but CC cord-335975-m6lkrehi 1397 12 their -PRON- PRP$ cord-335975-m6lkrehi 1397 13 routine routine JJ cord-335975-m6lkrehi 1397 14 use use NN cord-335975-m6lkrehi 1397 15 still still RB cord-335975-m6lkrehi 1397 16 remains remain VBZ cord-335975-m6lkrehi 1397 17 inaccurate inaccurate JJ cord-335975-m6lkrehi 1397 18 and and CC cord-335975-m6lkrehi 1397 19 subjective subjective JJ cord-335975-m6lkrehi 1397 20 . . . cord-335975-m6lkrehi 1398 1 Analgesia Analgesia NNP cord-335975-m6lkrehi 1398 2 Nociception Nociception NNP cord-335975-m6lkrehi 1398 3 Index Index NNP cord-335975-m6lkrehi 1398 4 ( ( -LRB- cord-335975-m6lkrehi 1398 5 ANI ANI NNP cord-335975-m6lkrehi 1398 6 ) ) -RRB- cord-335975-m6lkrehi 1398 7 is be VBZ cord-335975-m6lkrehi 1398 8 based base VBN cord-335975-m6lkrehi 1398 9 on on IN cord-335975-m6lkrehi 1398 10 high high JJ cord-335975-m6lkrehi 1398 11 - - HYPH cord-335975-m6lkrehi 1398 12 frequency frequency NN cord-335975-m6lkrehi 1398 13 heart heart NN cord-335975-m6lkrehi 1398 14 rate rate NN cord-335975-m6lkrehi 1398 15 variability variability NN cord-335975-m6lkrehi 1398 16 . . . cord-335975-m6lkrehi 1399 1 This this DT cord-335975-m6lkrehi 1399 2 study study NN cord-335975-m6lkrehi 1399 3 objective objective NN cord-335975-m6lkrehi 1399 4 was be VBD cord-335975-m6lkrehi 1399 5 to to TO cord-335975-m6lkrehi 1399 6 assess assess VB cord-335975-m6lkrehi 1399 7 the the DT cord-335975-m6lkrehi 1399 8 correlation correlation NN cord-335975-m6lkrehi 1399 9 between between IN cord-335975-m6lkrehi 1399 10 the the DT cord-335975-m6lkrehi 1399 11 Behavioral behavioral JJ cord-335975-m6lkrehi 1399 12 Pain pain NN cord-335975-m6lkrehi 1399 13 Scale scale NN cord-335975-m6lkrehi 1399 14 ( ( -LRB- cord-335975-m6lkrehi 1399 15 BPS BPS NNP cord-335975-m6lkrehi 1399 16 ) ) -RRB- cord-335975-m6lkrehi 1399 17 and and CC cord-335975-m6lkrehi 1399 18 ANI ANI NNP cord-335975-m6lkrehi 1399 19 during during IN cord-335975-m6lkrehi 1399 20 care care NN cord-335975-m6lkrehi 1399 21 procedures procedure NNS cord-335975-m6lkrehi 1399 22 in in IN cord-335975-m6lkrehi 1399 23 deeply deeply RB cord-335975-m6lkrehi 1399 24 sedated sedated JJ cord-335975-m6lkrehi 1399 25 patients patient NNS cord-335975-m6lkrehi 1399 26 . . . cord-335975-m6lkrehi 1400 1 We -PRON- PRP cord-335975-m6lkrehi 1400 2 conduced conduce VBD cord-335975-m6lkrehi 1400 3 a a DT cord-335975-m6lkrehi 1400 4 French french JJ cord-335975-m6lkrehi 1400 5 multicentric multicentric JJ cord-335975-m6lkrehi 1400 6 prospective prospective JJ cord-335975-m6lkrehi 1400 7 observational observational JJ cord-335975-m6lkrehi 1400 8 study study NN cord-335975-m6lkrehi 1400 9 with with IN cord-335975-m6lkrehi 1400 10 blinded blind VBN cord-335975-m6lkrehi 1400 11 continuous continuous JJ cord-335975-m6lkrehi 1400 12 recording recording NN cord-335975-m6lkrehi 1400 13 of of IN cord-335975-m6lkrehi 1400 14 ANI ANI NNP cord-335975-m6lkrehi 1400 15 during during IN cord-335975-m6lkrehi 1400 16 8 8 CD cord-335975-m6lkrehi 1400 17 h h NN cord-335975-m6lkrehi 1400 18 with with IN cord-335975-m6lkrehi 1400 19 spotting spotting NN cord-335975-m6lkrehi 1400 20 of of IN cord-335975-m6lkrehi 1400 21 care care NN cord-335975-m6lkrehi 1400 22 procedures procedure NNS cord-335975-m6lkrehi 1400 23 in in IN cord-335975-m6lkrehi 1400 24 patients patient NNS cord-335975-m6lkrehi 1400 25 with with IN cord-335975-m6lkrehi 1400 26 RASS RASS NNP cord-335975-m6lkrehi 1400 27 less less RBR cord-335975-m6lkrehi 1400 28 or or CC cord-335975-m6lkrehi 1400 29 equal equal JJ cord-335975-m6lkrehi 1400 30 to to IN cord-335975-m6lkrehi 1400 31 − − CD cord-335975-m6lkrehi 1400 32 2 2 CD cord-335975-m6lkrehi 1400 33 . . . cord-335975-m6lkrehi 1401 1 We -PRON- PRP cord-335975-m6lkrehi 1401 2 compared compare VBD cord-335975-m6lkrehi 1401 3 pain pain NN cord-335975-m6lkrehi 1401 4 assessment assessment NN cord-335975-m6lkrehi 1401 5 using use VBG cord-335975-m6lkrehi 1401 6 BPS BPS NNP cord-335975-m6lkrehi 1401 7 and and CC cord-335975-m6lkrehi 1401 8 ANI ANI NNP cord-335975-m6lkrehi 1401 9 before before IN cord-335975-m6lkrehi 1401 10 ( ( -LRB- cord-335975-m6lkrehi 1401 11 t1 t1 NNP cord-335975-m6lkrehi 1401 12 ) ) -RRB- cord-335975-m6lkrehi 1401 13 and and CC cord-335975-m6lkrehi 1401 14 during during IN cord-335975-m6lkrehi 1401 15 ( ( -LRB- cord-335975-m6lkrehi 1401 16 t2 t2 NNP cord-335975-m6lkrehi 1401 17 ) ) -RRB- cord-335975-m6lkrehi 1401 18 each each DT cord-335975-m6lkrehi 1401 19 care care NN cord-335975-m6lkrehi 1401 20 procedure procedure NN cord-335975-m6lkrehi 1401 21 . . . cord-335975-m6lkrehi 1402 1 The the DT cord-335975-m6lkrehi 1402 2 cares care NNS cord-335975-m6lkrehi 1402 3 analyzed analyze VBD cord-335975-m6lkrehi 1402 4 included include VBN cord-335975-m6lkrehi 1402 5 prick prick NNP cord-335975-m6lkrehi 1402 6 glycaemia glycaemia NNP cord-335975-m6lkrehi 1402 7 , , , cord-335975-m6lkrehi 1402 8 turning turning NN cord-335975-m6lkrehi 1402 9 , , , cord-335975-m6lkrehi 1402 10 catheter catheter NN cord-335975-m6lkrehi 1402 11 insertion insertion NN cord-335975-m6lkrehi 1402 12 , , , cord-335975-m6lkrehi 1402 13 dressing dressing NN cord-335975-m6lkrehi 1402 14 change change NN cord-335975-m6lkrehi 1402 15 and and CC cord-335975-m6lkrehi 1402 16 others other NNS cord-335975-m6lkrehi 1402 17 . . . cord-335975-m6lkrehi 1403 1 A a DT cord-335975-m6lkrehi 1403 2 behavioral behavioral JJ cord-335975-m6lkrehi 1403 3 pain pain NN cord-335975-m6lkrehi 1403 4 reactivity reactivity NN cord-335975-m6lkrehi 1403 5 ( ( -LRB- cord-335975-m6lkrehi 1403 6 BPR BPR NNP cord-335975-m6lkrehi 1403 7 ) ) -RRB- cord-335975-m6lkrehi 1403 8 was be VBD cord-335975-m6lkrehi 1403 9 defined define VBN cord-335975-m6lkrehi 1403 10 by by IN cord-335975-m6lkrehi 1403 11 a a DT cord-335975-m6lkrehi 1403 12 BPS BPS NNP cord-335975-m6lkrehi 1403 13 elevation elevation NN cord-335975-m6lkrehi 1403 14 of of IN cord-335975-m6lkrehi 1403 15 at at RB cord-335975-m6lkrehi 1403 16 least least JJS cord-335975-m6lkrehi 1403 17 1 1 CD cord-335975-m6lkrehi 1403 18 point point NN cord-335975-m6lkrehi 1403 19 . . . cord-335975-m6lkrehi 1404 1 We -PRON- PRP cord-335975-m6lkrehi 1404 2 analyzed analyze VBD cord-335975-m6lkrehi 1404 3 minimal minimal JJ cord-335975-m6lkrehi 1404 4 ANI ANI NNP cord-335975-m6lkrehi 1404 5 values value NNS cord-335975-m6lkrehi 1404 6 and and CC cord-335975-m6lkrehi 1404 7 its -PRON- PRP$ cord-335975-m6lkrehi 1404 8 variations variation NNS cord-335975-m6lkrehi 1404 9 with with IN cord-335975-m6lkrehi 1404 10 calculation calculation NN cord-335975-m6lkrehi 1404 11 of of IN cord-335975-m6lkrehi 1404 12 DeltaANI deltaani JJ cord-335975-m6lkrehi 1404 13 ( ( -LRB- cord-335975-m6lkrehi 1404 14 ANIt1-ANIt2 ANIt1-ANIt2 NNP cord-335975-m6lkrehi 1404 15 ) ) -RRB- cord-335975-m6lkrehi 1404 16 . . . cord-335975-m6lkrehi 1405 1 Because because IN cord-335975-m6lkrehi 1405 2 of of IN cord-335975-m6lkrehi 1405 3 the the DT cord-335975-m6lkrehi 1405 4 analysis analysis NN cord-335975-m6lkrehi 1405 5 of of IN cord-335975-m6lkrehi 1405 6 several several JJ cord-335975-m6lkrehi 1405 7 cares care NNS cord-335975-m6lkrehi 1405 8 per per IN cord-335975-m6lkrehi 1405 9 patient patient NN cord-335975-m6lkrehi 1405 10 we -PRON- PRP cord-335975-m6lkrehi 1405 11 used use VBD cord-335975-m6lkrehi 1405 12 a a DT cord-335975-m6lkrehi 1405 13 Bonferroni Bonferroni NNP cord-335975-m6lkrehi 1405 14 's 's POS cord-335975-m6lkrehi 1405 15 correction correction NN cord-335975-m6lkrehi 1405 16 in in IN cord-335975-m6lkrehi 1405 17 comparison comparison NN cord-335975-m6lkrehi 1405 18 of of IN cord-335975-m6lkrehi 1405 19 BPR BPR NNP cord-335975-m6lkrehi 1405 20 and and CC cord-335975-m6lkrehi 1405 21 no no DT cord-335975-m6lkrehi 1405 22 BPR BPR NNP cord-335975-m6lkrehi 1405 23 groups group NNS cord-335975-m6lkrehi 1405 24 with with IN cord-335975-m6lkrehi 1405 25 a a DT cord-335975-m6lkrehi 1405 26 significant significant JJ cord-335975-m6lkrehi 1405 27 p p NN cord-335975-m6lkrehi 1405 28 value value NN cord-335975-m6lkrehi 1405 29 < < XX cord-335975-m6lkrehi 1405 30 0.025 0.025 CD cord-335975-m6lkrehi 1405 31 for for IN cord-335975-m6lkrehi 1405 32 this this DT cord-335975-m6lkrehi 1405 33 comparison comparison NN cord-335975-m6lkrehi 1405 34 . . . cord-335975-m6lkrehi 1406 1 For for IN cord-335975-m6lkrehi 1406 2 others other NNS cord-335975-m6lkrehi 1406 3 analyses analyse VBZ cord-335975-m6lkrehi 1406 4 the the DT cord-335975-m6lkrehi 1406 5 p p NN cord-335975-m6lkrehi 1406 6 value value NN cord-335975-m6lkrehi 1406 7 considered consider VBN cord-335975-m6lkrehi 1406 8 as as IN cord-335975-m6lkrehi 1406 9 significant significant JJ cord-335975-m6lkrehi 1406 10 was be VBD cord-335975-m6lkrehi 1406 11 p p NN cord-335975-m6lkrehi 1406 12 < < XX cord-335975-m6lkrehi 1406 13 0.05 0.05 CD cord-335975-m6lkrehi 1406 14 . . . cord-335975-m6lkrehi 1407 1 Correlation correlation NN cord-335975-m6lkrehi 1407 2 between between IN cord-335975-m6lkrehi 1407 3 ANI ANI NNP cord-335975-m6lkrehi 1407 4 and and CC cord-335975-m6lkrehi 1407 5 BPS BPS NNP cord-335975-m6lkrehi 1407 6 was be VBD cord-335975-m6lkrehi 1407 7 analyzed analyze VBN cord-335975-m6lkrehi 1407 8 using use VBG cord-335975-m6lkrehi 1407 9 a a DT cord-335975-m6lkrehi 1407 10 Spearman Spearman NNP cord-335975-m6lkrehi 1407 11 correlation correlation NN cord-335975-m6lkrehi 1407 12 rank rank NN cord-335975-m6lkrehi 1407 13 test test NN cord-335975-m6lkrehi 1407 14 . . . cord-335975-m6lkrehi 1408 1 Introduction introduction NN cord-335975-m6lkrehi 1408 2 : : : cord-335975-m6lkrehi 1409 1 The the DT cord-335975-m6lkrehi 1409 2 pain pain NN cord-335975-m6lkrehi 1409 3 associated associate VBN cord-335975-m6lkrehi 1409 4 with with IN cord-335975-m6lkrehi 1409 5 burn burn NN cord-335975-m6lkrehi 1409 6 was be VBD cord-335975-m6lkrehi 1409 7 one one CD cord-335975-m6lkrehi 1409 8 of of IN cord-335975-m6lkrehi 1409 9 the the DT cord-335975-m6lkrehi 1409 10 most most RBS cord-335975-m6lkrehi 1409 11 painful painful JJ cord-335975-m6lkrehi 1409 12 injuries injury NNS cord-335975-m6lkrehi 1409 13 to to TO cord-335975-m6lkrehi 1409 14 treat treat VB cord-335975-m6lkrehi 1409 15 . . . cord-335975-m6lkrehi 1410 1 Pain pain NN cord-335975-m6lkrehi 1410 2 was be VBD cord-335975-m6lkrehi 1410 3 induced induce VBN cord-335975-m6lkrehi 1410 4 by by IN cord-335975-m6lkrehi 1410 5 therapeutic therapeutic JJ cord-335975-m6lkrehi 1410 6 acts act NNS cord-335975-m6lkrehi 1410 7 such such JJ cord-335975-m6lkrehi 1410 8 as as IN cord-335975-m6lkrehi 1410 9 wound wind VBN cord-335975-m6lkrehi 1410 10 debridement debridement NN cord-335975-m6lkrehi 1410 11 , , , cord-335975-m6lkrehi 1410 12 dressing dressing NN cord-335975-m6lkrehi 1410 13 and and CC cord-335975-m6lkrehi 1410 14 other other JJ cord-335975-m6lkrehi 1410 15 painful painful JJ cord-335975-m6lkrehi 1410 16 procedures procedure NNS cord-335975-m6lkrehi 1410 17 . . . cord-335975-m6lkrehi 1411 1 Burn burn VB cord-335975-m6lkrehi 1411 2 pain pain NN cord-335975-m6lkrehi 1411 3 caused cause VBD cord-335975-m6lkrehi 1411 4 changes change NNS cord-335975-m6lkrehi 1411 5 in in IN cord-335975-m6lkrehi 1411 6 neurophysiology neurophysiology NN cord-335975-m6lkrehi 1411 7 and and CC cord-335975-m6lkrehi 1411 8 pharmacokinetics pharmacokinetic NNS cord-335975-m6lkrehi 1411 9 that that WDT cord-335975-m6lkrehi 1411 10 may may MD cord-335975-m6lkrehi 1411 11 make make VB cord-335975-m6lkrehi 1411 12 standard standard JJ cord-335975-m6lkrehi 1411 13 pharmacologic pharmacologic JJ cord-335975-m6lkrehi 1411 14 analgesic analgesic NN cord-335975-m6lkrehi 1411 15 therapy therapy NN cord-335975-m6lkrehi 1411 16 less less RBR cord-335975-m6lkrehi 1411 17 effective effective JJ cord-335975-m6lkrehi 1411 18 than than IN cord-335975-m6lkrehi 1411 19 usual.virtual usual.virtual JJ cord-335975-m6lkrehi 1411 20 reality reality NN cord-335975-m6lkrehi 1411 21 has have VBZ cord-335975-m6lkrehi 1411 22 been be VBN cord-335975-m6lkrehi 1411 23 explored explore VBN cord-335975-m6lkrehi 1411 24 as as IN cord-335975-m6lkrehi 1411 25 an an DT cord-335975-m6lkrehi 1411 26 adjunct adjunct JJ cord-335975-m6lkrehi 1411 27 therapy therapy NN cord-335975-m6lkrehi 1411 28 for for IN cord-335975-m6lkrehi 1411 29 the the DT cord-335975-m6lkrehi 1411 30 management management NN cord-335975-m6lkrehi 1411 31 of of IN cord-335975-m6lkrehi 1411 32 acute acute JJ cord-335975-m6lkrehi 1411 33 pain pain NN cord-335975-m6lkrehi 1411 34 for for IN cord-335975-m6lkrehi 1411 35 a a DT cord-335975-m6lkrehi 1411 36 number number NN cord-335975-m6lkrehi 1411 37 of of IN cord-335975-m6lkrehi 1411 38 conditions condition NNS cord-335975-m6lkrehi 1411 39 . . . cord-335975-m6lkrehi 1412 1 In in IN cord-335975-m6lkrehi 1412 2 our -PRON- PRP$ cord-335975-m6lkrehi 1412 3 study study NN cord-335975-m6lkrehi 1412 4 , , , cord-335975-m6lkrehi 1412 5 we -PRON- PRP cord-335975-m6lkrehi 1412 6 attempt attempt VBP cord-335975-m6lkrehi 1412 7 to to TO cord-335975-m6lkrehi 1412 8 assess assess VB cord-335975-m6lkrehi 1412 9 the the DT cord-335975-m6lkrehi 1412 10 impact impact NN cord-335975-m6lkrehi 1412 11 of of IN cord-335975-m6lkrehi 1412 12 virtual virtual JJ cord-335975-m6lkrehi 1412 13 reality reality NN cord-335975-m6lkrehi 1412 14 on on IN cord-335975-m6lkrehi 1412 15 management management NN cord-335975-m6lkrehi 1412 16 of of IN cord-335975-m6lkrehi 1412 17 burn burn NN cord-335975-m6lkrehi 1412 18 pain pain NN cord-335975-m6lkrehi 1412 19 during during IN cord-335975-m6lkrehi 1412 20 dressing dressing NN cord-335975-m6lkrehi 1412 21 changes change NNS cord-335975-m6lkrehi 1412 22 . . . cord-335975-m6lkrehi 1413 1 Patients patient NNS cord-335975-m6lkrehi 1413 2 and and CC cord-335975-m6lkrehi 1413 3 methods method NNS cord-335975-m6lkrehi 1413 4 : : : cord-335975-m6lkrehi 1413 5 Before before IN cord-335975-m6lkrehi 1413 6 the the DT cord-335975-m6lkrehi 1413 7 therapeutic therapeutic JJ cord-335975-m6lkrehi 1413 8 procedure procedure NN cord-335975-m6lkrehi 1413 9 ( ( -LRB- cord-335975-m6lkrehi 1413 10 dressing dressing NN cord-335975-m6lkrehi 1413 11 changes change NNS cord-335975-m6lkrehi 1413 12 ) ) -RRB- cord-335975-m6lkrehi 1413 13 , , , cord-335975-m6lkrehi 1413 14 the the DT cord-335975-m6lkrehi 1413 15 concept concept NN cord-335975-m6lkrehi 1413 16 of of IN cord-335975-m6lkrehi 1413 17 virtual virtual JJ cord-335975-m6lkrehi 1413 18 reality reality NN cord-335975-m6lkrehi 1413 19 therapy therapy NN cord-335975-m6lkrehi 1413 20 was be VBD cord-335975-m6lkrehi 1413 21 explained explain VBN cord-335975-m6lkrehi 1413 22 to to IN cord-335975-m6lkrehi 1413 23 the the DT cord-335975-m6lkrehi 1413 24 patient patient NN cord-335975-m6lkrehi 1413 25 ( ( -LRB- cord-335975-m6lkrehi 1413 26 technology technology NN cord-335975-m6lkrehi 1413 27 and and CC cord-335975-m6lkrehi 1413 28 equipment equipment NN cord-335975-m6lkrehi 1413 29 used use VBN cord-335975-m6lkrehi 1413 30 ) ) -RRB- cord-335975-m6lkrehi 1413 31 . . . cord-335975-m6lkrehi 1414 1 The the DT cord-335975-m6lkrehi 1414 2 video video NN cord-335975-m6lkrehi 1414 3 used use VBN cord-335975-m6lkrehi 1414 4 was be VBD cord-335975-m6lkrehi 1414 5 snow snow NN cord-335975-m6lkrehi 1414 6 mountain mountain NN cord-335975-m6lkrehi 1414 7 . . . cord-335975-m6lkrehi 1415 1 During during IN cord-335975-m6lkrehi 1415 2 the the DT cord-335975-m6lkrehi 1415 3 act act NN cord-335975-m6lkrehi 1415 4 , , , cord-335975-m6lkrehi 1415 5 pain pain NN cord-335975-m6lkrehi 1415 6 was be VBD cord-335975-m6lkrehi 1415 7 assessed assess VBN cord-335975-m6lkrehi 1415 8 until until IN cord-335975-m6lkrehi 1415 9 the the DT cord-335975-m6lkrehi 1415 10 end end NN cord-335975-m6lkrehi 1415 11 of of IN cord-335975-m6lkrehi 1415 12 the the DT cord-335975-m6lkrehi 1415 13 procedure procedure NN cord-335975-m6lkrehi 1415 14 . . . cord-335975-m6lkrehi 1416 1 The the DT cord-335975-m6lkrehi 1416 2 assessment assessment NN cord-335975-m6lkrehi 1416 3 of of IN cord-335975-m6lkrehi 1416 4 pain pain NN cord-335975-m6lkrehi 1416 5 was be VBD cord-335975-m6lkrehi 1416 6 based base VBN cord-335975-m6lkrehi 1416 7 on on IN cord-335975-m6lkrehi 1416 8 visual visual JJ cord-335975-m6lkrehi 1416 9 analog analog NN cord-335975-m6lkrehi 1416 10 scale scale NN cord-335975-m6lkrehi 1416 11 ( ( -LRB- cord-335975-m6lkrehi 1416 12 vas vas NN cord-335975-m6lkrehi 1416 13 ) ) -RRB- cord-335975-m6lkrehi 1416 14 . . . cord-335975-m6lkrehi 1417 1 For for IN cord-335975-m6lkrehi 1417 2 pain pain NN cord-335975-m6lkrehi 1417 3 intensity intensity NN cord-335975-m6lkrehi 1417 4 , , , cord-335975-m6lkrehi 1417 5 the the DT cord-335975-m6lkrehi 1417 6 scale scale NN cord-335975-m6lkrehi 1417 7 was be VBD cord-335975-m6lkrehi 1417 8 most most RBS cord-335975-m6lkrehi 1417 9 commonly commonly RB cord-335975-m6lkrehi 1417 10 anchored anchor VBN cord-335975-m6lkrehi 1417 11 by by IN cord-335975-m6lkrehi 1417 12 " " `` cord-335975-m6lkrehi 1417 13 no no DT cord-335975-m6lkrehi 1417 14 pain pain NN cord-335975-m6lkrehi 1417 15 " " '' cord-335975-m6lkrehi 1417 16 ( ( -LRB- cord-335975-m6lkrehi 1417 17 score score NN cord-335975-m6lkrehi 1417 18 of of IN cord-335975-m6lkrehi 1417 19 0 0 CD cord-335975-m6lkrehi 1417 20 ) ) -RRB- cord-335975-m6lkrehi 1417 21 and and CC cord-335975-m6lkrehi 1417 22 " " `` cord-335975-m6lkrehi 1417 23 very very RB cord-335975-m6lkrehi 1417 24 intense intense JJ cord-335975-m6lkrehi 1417 25 pain pain NN cord-335975-m6lkrehi 1417 26 " " '' cord-335975-m6lkrehi 1417 27 ( ( -LRB- cord-335975-m6lkrehi 1417 28 score score NN cord-335975-m6lkrehi 1417 29 of of IN cord-335975-m6lkrehi 1417 30 10 10 CD cord-335975-m6lkrehi 1417 31 ) ) -RRB- cord-335975-m6lkrehi 1417 32 . . . cord-335975-m6lkrehi 1418 1 Results result NNS cord-335975-m6lkrehi 1418 2 : : : cord-335975-m6lkrehi 1419 1 During during IN cord-335975-m6lkrehi 1419 2 the the DT cord-335975-m6lkrehi 1419 3 study study NN cord-335975-m6lkrehi 1419 4 period period NN cord-335975-m6lkrehi 1419 5 , , , cord-335975-m6lkrehi 1419 6 20 20 CD cord-335975-m6lkrehi 1419 7 patients patient NNS cord-335975-m6lkrehi 1419 8 were be VBD cord-335975-m6lkrehi 1419 9 included include VBN cord-335975-m6lkrehi 1419 10 . . . cord-335975-m6lkrehi 1420 1 The the DT cord-335975-m6lkrehi 1420 2 mean mean JJ cord-335975-m6lkrehi 1420 3 age age NN cord-335975-m6lkrehi 1420 4 was be VBD cord-335975-m6lkrehi 1420 5 32 32 CD cord-335975-m6lkrehi 1420 6 ± ± NNP cord-335975-m6lkrehi 1420 7 17 17 CD cord-335975-m6lkrehi 1420 8 years year NNS cord-335975-m6lkrehi 1420 9 . . . cord-335975-m6lkrehi 1421 1 75 75 CD cord-335975-m6lkrehi 1421 2 % % NN cord-335975-m6lkrehi 1421 3 of of IN cord-335975-m6lkrehi 1421 4 our -PRON- PRP$ cord-335975-m6lkrehi 1421 5 patients patient NNS cord-335975-m6lkrehi 1421 6 were be VBD cord-335975-m6lkrehi 1421 7 adults adult NNS cord-335975-m6lkrehi 1421 8 aged age VBN cord-335975-m6lkrehi 1421 9 over over IN cord-335975-m6lkrehi 1421 10 20 20 CD cord-335975-m6lkrehi 1421 11 years year NNS cord-335975-m6lkrehi 1421 12 . . . cord-335975-m6lkrehi 1422 1 They -PRON- PRP cord-335975-m6lkrehi 1422 2 were be VBD cord-335975-m6lkrehi 1422 3 17 17 CD cord-335975-m6lkrehi 1422 4 men man NNS cord-335975-m6lkrehi 1422 5 and and CC cord-335975-m6lkrehi 1422 6 3 3 CD cord-335975-m6lkrehi 1422 7 women woman NNS cord-335975-m6lkrehi 1422 8 . . . cord-335975-m6lkrehi 1423 1 the the DT cord-335975-m6lkrehi 1423 2 average average NN cord-335975-m6lkrehi 1423 3 burned burn VBN cord-335975-m6lkrehi 1423 4 surface surface NN cord-335975-m6lkrehi 1423 5 area area NN cord-335975-m6lkrehi 1423 6 was be VBD cord-335975-m6lkrehi 1423 7 30 30 CD cord-335975-m6lkrehi 1423 8 ± ± CD cord-335975-m6lkrehi 1423 9 13 13 CD cord-335975-m6lkrehi 1423 10 % % NN cord-335975-m6lkrehi 1423 11 . . . cord-335975-m6lkrehi 1424 1 Pain pain NN cord-335975-m6lkrehi 1424 2 was be VBD cord-335975-m6lkrehi 1424 3 evaluated evaluate VBN cord-335975-m6lkrehi 1424 4 before before IN cord-335975-m6lkrehi 1424 5 the the DT cord-335975-m6lkrehi 1424 6 start start NN cord-335975-m6lkrehi 1424 7 of of IN cord-335975-m6lkrehi 1424 8 the the DT cord-335975-m6lkrehi 1424 9 therapeutic therapeutic JJ cord-335975-m6lkrehi 1424 10 procedure procedure NN cord-335975-m6lkrehi 1424 11 . . . cord-335975-m6lkrehi 1425 1 The the DT cord-335975-m6lkrehi 1425 2 mean mean JJ cord-335975-m6lkrehi 1425 3 initial initial JJ cord-335975-m6lkrehi 1425 4 pain pain NN cord-335975-m6lkrehi 1425 5 severity severity NN cord-335975-m6lkrehi 1425 6 score score NN cord-335975-m6lkrehi 1425 7 was be VBD cord-335975-m6lkrehi 1425 8 8.85 8.85 CD cord-335975-m6lkrehi 1425 9 ± ± CD cord-335975-m6lkrehi 1425 10 0.74 0.74 CD cord-335975-m6lkrehi 1426 1 ( ( -LRB- cord-335975-m6lkrehi 1426 2 range range NN cord-335975-m6lkrehi 1426 3 8 8 CD cord-335975-m6lkrehi 1426 4 to to IN cord-335975-m6lkrehi 1426 5 10 10 CD cord-335975-m6lkrehi 1426 6 ) ) -RRB- cord-335975-m6lkrehi 1426 7 . . . cord-335975-m6lkrehi 1427 1 The the DT cord-335975-m6lkrehi 1427 2 pain pain NN cord-335975-m6lkrehi 1427 3 assessment assessment NN cord-335975-m6lkrehi 1427 4 after after IN cord-335975-m6lkrehi 1427 5 virtual virtual JJ cord-335975-m6lkrehi 1427 6 reality reality NN cord-335975-m6lkrehi 1427 7 condition condition NN cord-335975-m6lkrehi 1427 8 showed show VBD cord-335975-m6lkrehi 1427 9 a a DT cord-335975-m6lkrehi 1427 10 significant significant JJ cord-335975-m6lkrehi 1427 11 decrease decrease NN cord-335975-m6lkrehi 1427 12 in in IN cord-335975-m6lkrehi 1427 13 the the DT cord-335975-m6lkrehi 1427 14 intensity intensity NN cord-335975-m6lkrehi 1427 15 of of IN cord-335975-m6lkrehi 1427 16 pain pain NN cord-335975-m6lkrehi 1427 17 ( ( -LRB- cord-335975-m6lkrehi 1427 18 p p NN cord-335975-m6lkrehi 1427 19 < < XX cord-335975-m6lkrehi 1427 20 0.01 0.01 CD cord-335975-m6lkrehi 1427 21 ) ) -RRB- cord-335975-m6lkrehi 1427 22 . . . cord-335975-m6lkrehi 1428 1 The the DT cord-335975-m6lkrehi 1428 2 mean mean JJ cord-335975-m6lkrehi 1428 3 pain pain NN cord-335975-m6lkrehi 1428 4 decreased decrease VBD cord-335975-m6lkrehi 1428 5 from from IN cord-335975-m6lkrehi 1428 6 8.85 8.85 CD cord-335975-m6lkrehi 1428 7 to to IN cord-335975-m6lkrehi 1428 8 4.6 4.6 CD cord-335975-m6lkrehi 1428 9 ± ± CD cord-335975-m6lkrehi 1428 10 0.84 0.84 CD cord-335975-m6lkrehi 1428 11 with with IN cord-335975-m6lkrehi 1428 12 extremes extreme NNS cord-335975-m6lkrehi 1428 13 ranging range VBG cord-335975-m6lkrehi 1428 14 from from IN cord-335975-m6lkrehi 1428 15 1 1 CD cord-335975-m6lkrehi 1428 16 to to IN cord-335975-m6lkrehi 1428 17 4 4 CD cord-335975-m6lkrehi 1428 18 . . . cord-335975-m6lkrehi 1429 1 Conclusion conclusion NN cord-335975-m6lkrehi 1429 2 : : : cord-335975-m6lkrehi 1430 1 Our -PRON- PRP$ cord-335975-m6lkrehi 1430 2 study study NN cord-335975-m6lkrehi 1430 3 supports support VBZ cord-335975-m6lkrehi 1430 4 the the DT cord-335975-m6lkrehi 1430 5 use use NN cord-335975-m6lkrehi 1430 6 of of IN cord-335975-m6lkrehi 1430 7 virtual virtual JJ cord-335975-m6lkrehi 1430 8 reality reality NN cord-335975-m6lkrehi 1430 9 , , , cord-335975-m6lkrehi 1430 10 simple simple JJ cord-335975-m6lkrehi 1430 11 noninvasive noninvasive JJ cord-335975-m6lkrehi 1430 12 , , , cord-335975-m6lkrehi 1430 13 as as IN cord-335975-m6lkrehi 1430 14 an an DT cord-335975-m6lkrehi 1430 15 adjunct adjunct JJ cord-335975-m6lkrehi 1430 16 therapy therapy NN cord-335975-m6lkrehi 1430 17 in in IN cord-335975-m6lkrehi 1430 18 the the DT cord-335975-m6lkrehi 1430 19 management management NN cord-335975-m6lkrehi 1430 20 of of IN cord-335975-m6lkrehi 1430 21 pain pain NN cord-335975-m6lkrehi 1430 22 associated associate VBN cord-335975-m6lkrehi 1430 23 with with IN cord-335975-m6lkrehi 1430 24 dressing dress VBG cord-335975-m6lkrehi 1430 25 changes change NNS cord-335975-m6lkrehi 1430 26 in in IN cord-335975-m6lkrehi 1430 27 burn burn NN cord-335975-m6lkrehi 1430 28 patients patient NNS cord-335975-m6lkrehi 1430 29 . . . cord-335975-m6lkrehi 1431 1 Introduction introduction NN cord-335975-m6lkrehi 1431 2 : : : cord-335975-m6lkrehi 1432 1 Hypno Hypno NNP cord-335975-m6lkrehi 1432 2 - - HYPH cord-335975-m6lkrehi 1432 3 analgesia analgesia NN cord-335975-m6lkrehi 1432 4 ( ( -LRB- cord-335975-m6lkrehi 1432 5 HA HA NNP cord-335975-m6lkrehi 1432 6 ) ) -RRB- cord-335975-m6lkrehi 1432 7 is be VBZ cord-335975-m6lkrehi 1432 8 used use VBN cord-335975-m6lkrehi 1432 9 in in IN cord-335975-m6lkrehi 1432 10 the the DT cord-335975-m6lkrehi 1432 11 operating operating NN cord-335975-m6lkrehi 1432 12 room room NN cord-335975-m6lkrehi 1432 13 and and CC cord-335975-m6lkrehi 1432 14 for for IN cord-335975-m6lkrehi 1432 15 complex complex JJ cord-335975-m6lkrehi 1432 16 pain pain NN cord-335975-m6lkrehi 1432 17 . . . cord-335975-m6lkrehi 1433 1 Before before IN cord-335975-m6lkrehi 1433 2 implementation implementation NN cord-335975-m6lkrehi 1433 3 of of IN cord-335975-m6lkrehi 1433 4 HA HA NNP cord-335975-m6lkrehi 1433 5 in in IN cord-335975-m6lkrehi 1433 6 our -PRON- PRP$ cord-335975-m6lkrehi 1433 7 intensive intensive JJ cord-335975-m6lkrehi 1433 8 care care NN cord-335975-m6lkrehi 1433 9 unit unit NN cord-335975-m6lkrehi 1433 10 ( ( -LRB- cord-335975-m6lkrehi 1433 11 ICU ICU NNP cord-335975-m6lkrehi 1433 12 ) ) -RRB- cord-335975-m6lkrehi 1433 13 , , , cord-335975-m6lkrehi 1433 14 most most JJS cord-335975-m6lkrehi 1433 15 protocols protocol NNS cord-335975-m6lkrehi 1433 16 for for IN cord-335975-m6lkrehi 1433 17 algogenic algogenic NNP cord-335975-m6lkrehi 1433 18 procedures procedure NNS cord-335975-m6lkrehi 1433 19 included include VBD cord-335975-m6lkrehi 1433 20 intravenous intravenous JJ cord-335975-m6lkrehi 1433 21 or or CC cord-335975-m6lkrehi 1433 22 epidural epidural NN cord-335975-m6lkrehi 1433 23 morphine morphine NN cord-335975-m6lkrehi 1433 24 and and CC cord-335975-m6lkrehi 1433 25 Nitrous Nitrous NNP cord-335975-m6lkrehi 1433 26 Oxid Oxid NNP cord-335975-m6lkrehi 1433 27 . . . cord-335975-m6lkrehi 1434 1 Since since IN cord-335975-m6lkrehi 1434 2 2016 2016 CD cord-335975-m6lkrehi 1434 3 , , , cord-335975-m6lkrehi 1434 4 many many JJ cord-335975-m6lkrehi 1434 5 caregivers caregiver NNS cord-335975-m6lkrehi 1434 6 have have VBP cord-335975-m6lkrehi 1434 7 been be VBN cord-335975-m6lkrehi 1434 8 trained train VBN cord-335975-m6lkrehi 1434 9 , , , cord-335975-m6lkrehi 1434 10 HA HA NNP cord-335975-m6lkrehi 1434 11 has have VBZ cord-335975-m6lkrehi 1434 12 been be VBN cord-335975-m6lkrehi 1434 13 implemented implement VBN cord-335975-m6lkrehi 1434 14 and and CC cord-335975-m6lkrehi 1434 15 patient patient JJ cord-335975-m6lkrehi 1434 16 comfort comfort NN cord-335975-m6lkrehi 1434 17 is be VBZ cord-335975-m6lkrehi 1434 18 evaluated evaluate VBN cord-335975-m6lkrehi 1434 19 using use VBG cord-335975-m6lkrehi 1434 20 1 1 CD cord-335975-m6lkrehi 1434 21 ) ) -RRB- cord-335975-m6lkrehi 1434 22 a a DT cord-335975-m6lkrehi 1434 23 specific specific JJ cord-335975-m6lkrehi 1434 24 analogic analogic JJ cord-335975-m6lkrehi 1434 25 scale scale NN cord-335975-m6lkrehi 1434 26 of of IN cord-335975-m6lkrehi 1434 27 comfort comfort NN cord-335975-m6lkrehi 1434 28 ( ( -LRB- cord-335975-m6lkrehi 1434 29 0 0 CD cord-335975-m6lkrehi 1434 30 to to IN cord-335975-m6lkrehi 1434 31 10 10 CD cord-335975-m6lkrehi 1434 32 ) ) -RRB- cord-335975-m6lkrehi 1434 33 before before IN cord-335975-m6lkrehi 1434 34 and and CC cord-335975-m6lkrehi 1434 35 after after IN cord-335975-m6lkrehi 1434 36 the the DT cord-335975-m6lkrehi 1434 37 procedure procedure NN cord-335975-m6lkrehi 1434 38 + + SYM cord-335975-m6lkrehi 1434 39 2 2 CD cord-335975-m6lkrehi 1434 40 ) ) -RRB- cord-335975-m6lkrehi 1434 41 at at IN cord-335975-m6lkrehi 1434 42 the the DT cord-335975-m6lkrehi 1434 43 end end NN cord-335975-m6lkrehi 1434 44 of of IN cord-335975-m6lkrehi 1434 45 the the DT cord-335975-m6lkrehi 1434 46 procedure procedure NN cord-335975-m6lkrehi 1434 47 , , , cord-335975-m6lkrehi 1434 48 a a DT cord-335975-m6lkrehi 1434 49 score score NN cord-335975-m6lkrehi 1434 50 of of IN cord-335975-m6lkrehi 1434 51 patient patient NN cord-335975-m6lkrehi 1434 52 and and CC cord-335975-m6lkrehi 1434 53 caregiver caregiver NN cord-335975-m6lkrehi 1434 54 comfort comfort NN cord-335975-m6lkrehi 1434 55 using use VBG cord-335975-m6lkrehi 1434 56 a a DT cord-335975-m6lkrehi 1434 57 five five CD cord-335975-m6lkrehi 1434 58 item item NN cord-335975-m6lkrehi 1434 59 questionnaire questionnaire NN cord-335975-m6lkrehi 1434 60 ( ( -LRB- cord-335975-m6lkrehi 1434 61 5 5 CD cord-335975-m6lkrehi 1434 62 to to TO cord-335975-m6lkrehi 1434 63 20 20 CD cord-335975-m6lkrehi 1434 64 points point NNS cord-335975-m6lkrehi 1434 65 ) ) -RRB- cord-335975-m6lkrehi 1434 66 . . . cord-335975-m6lkrehi 1435 1 This this DT cord-335975-m6lkrehi 1435 2 pilot pilot NN cord-335975-m6lkrehi 1435 3 prospective prospective JJ cord-335975-m6lkrehi 1435 4 study study NN cord-335975-m6lkrehi 1435 5 compares compare VBZ cord-335975-m6lkrehi 1435 6 HA HA NNP cord-335975-m6lkrehi 1435 7 versus versus IN cord-335975-m6lkrehi 1435 8 the the DT cord-335975-m6lkrehi 1435 9 standard standard JJ cord-335975-m6lkrehi 1435 10 protocol protocol NN cord-335975-m6lkrehi 1435 11 in in IN cord-335975-m6lkrehi 1435 12 the the DT cord-335975-m6lkrehi 1435 13 removal removal NN cord-335975-m6lkrehi 1435 14 of of IN cord-335975-m6lkrehi 1435 15 abdominal abdominal JJ cord-335975-m6lkrehi 1435 16 drains drain NNS cord-335975-m6lkrehi 1435 17 after after IN cord-335975-m6lkrehi 1435 18 digestive digestive JJ cord-335975-m6lkrehi 1435 19 surgery surgery NN cord-335975-m6lkrehi 1435 20 . . . cord-335975-m6lkrehi 1436 1 The the DT cord-335975-m6lkrehi 1436 2 main main JJ cord-335975-m6lkrehi 1436 3 objective objective NN cord-335975-m6lkrehi 1436 4 was be VBD cord-335975-m6lkrehi 1436 5 to to TO cord-335975-m6lkrehi 1436 6 evaluate evaluate VB cord-335975-m6lkrehi 1436 7 the the DT cord-335975-m6lkrehi 1436 8 patient patient JJ cord-335975-m6lkrehi 1436 9 comfort comfort NN cord-335975-m6lkrehi 1436 10 before before RB cord-335975-m6lkrehi 1436 11 after after IN cord-335975-m6lkrehi 1436 12 the the DT cord-335975-m6lkrehi 1436 13 procedure procedure NN cord-335975-m6lkrehi 1436 14 using use VBG cord-335975-m6lkrehi 1436 15 a a DT cord-335975-m6lkrehi 1436 16 scale scale NN cord-335975-m6lkrehi 1436 17 of of IN cord-335975-m6lkrehi 1436 18 comfort comfort NN cord-335975-m6lkrehi 1436 19 + + CC cord-335975-m6lkrehi 1436 20 the the DT cord-335975-m6lkrehi 1436 21 secondary secondary JJ cord-335975-m6lkrehi 1436 22 objectives objective NNS cord-335975-m6lkrehi 1436 23 were be VBD cord-335975-m6lkrehi 1436 24 to to TO cord-335975-m6lkrehi 1436 25 test test VB cord-335975-m6lkrehi 1436 26 the the DT cord-335975-m6lkrehi 1436 27 patient patient NN cord-335975-m6lkrehi 1436 28 and and CC cord-335975-m6lkrehi 1436 29 caregiver caregiver NN cord-335975-m6lkrehi 1436 30 comfort comfort NN cord-335975-m6lkrehi 1436 31 scores score NNS cord-335975-m6lkrehi 1436 32 and and CC cord-335975-m6lkrehi 1436 33 evaluate evaluate VB cord-335975-m6lkrehi 1436 34 in in IN cord-335975-m6lkrehi 1436 35 the the DT cord-335975-m6lkrehi 1436 36 impact impact NN cord-335975-m6lkrehi 1436 37 on on IN cord-335975-m6lkrehi 1436 38 consumption consumption NN cord-335975-m6lkrehi 1436 39 of of IN cord-335975-m6lkrehi 1436 40 analgesic analgesic NN cord-335975-m6lkrehi 1436 41 . . . cord-335975-m6lkrehi 1437 1 Between between IN cord-335975-m6lkrehi 1437 2 May May NNP cord-335975-m6lkrehi 1437 3 2016 2016 CD cord-335975-m6lkrehi 1437 4 and and CC cord-335975-m6lkrehi 1437 5 September September NNP cord-335975-m6lkrehi 1437 6 2017 2017 CD cord-335975-m6lkrehi 1437 7 , , , cord-335975-m6lkrehi 1437 8 two two CD cord-335975-m6lkrehi 1437 9 groups group NNS cord-335975-m6lkrehi 1437 10 were be VBD cord-335975-m6lkrehi 1437 11 obtained obtain VBN cord-335975-m6lkrehi 1437 12 , , , cord-335975-m6lkrehi 1437 13 according accord VBG cord-335975-m6lkrehi 1437 14 whether whether IN cord-335975-m6lkrehi 1437 15 the the DT cord-335975-m6lkrehi 1437 16 procedure procedure NN cord-335975-m6lkrehi 1437 17 was be VBD cord-335975-m6lkrehi 1437 18 performed perform VBN cord-335975-m6lkrehi 1437 19 by by IN cord-335975-m6lkrehi 1437 20 HA HA NNP cord-335975-m6lkrehi 1437 21 - - HYPH cord-335975-m6lkrehi 1437 22 trained train VBN cord-335975-m6lkrehi 1437 23 or or CC cord-335975-m6lkrehi 1437 24 non non JJ cord-335975-m6lkrehi 1437 25 - - JJ cord-335975-m6lkrehi 1437 26 HAtrained hatrained JJ cord-335975-m6lkrehi 1437 27 professionals professional NNS cord-335975-m6lkrehi 1437 28 ( ( -LRB- cord-335975-m6lkrehi 1437 29 depending depend VBG cord-335975-m6lkrehi 1437 30 on on IN cord-335975-m6lkrehi 1437 31 caregivers caregiver NNS cord-335975-m6lkrehi 1437 32 availability availability NN cord-335975-m6lkrehi 1437 33 in in IN cord-335975-m6lkrehi 1437 34 the the DT cord-335975-m6lkrehi 1437 35 unit unit NN cord-335975-m6lkrehi 1437 36 ) ) -RRB- cord-335975-m6lkrehi 1437 37 . . . cord-335975-m6lkrehi 1438 1 The the DT cord-335975-m6lkrehi 1438 2 number number NN cord-335975-m6lkrehi 1438 3 of of IN cord-335975-m6lkrehi 1438 4 subjects subject NNS cord-335975-m6lkrehi 1438 5 required require VBN cord-335975-m6lkrehi 1438 6 to to TO cord-335975-m6lkrehi 1438 7 compare compare VB cord-335975-m6lkrehi 1438 8 scales scale NNS cord-335975-m6lkrehi 1438 9 of of IN cord-335975-m6lkrehi 1438 10 comfort comfort NN cord-335975-m6lkrehi 1438 11 before before RB cord-335975-m6lkrehi 1438 12 vs. vs. CC cord-335975-m6lkrehi 1438 13 after after IN cord-335975-m6lkrehi 1438 14 drain drain NN cord-335975-m6lkrehi 1438 15 removal removal NN cord-335975-m6lkrehi 1438 16 was be VBD cord-335975-m6lkrehi 1438 17 66 66 CD cord-335975-m6lkrehi 1438 18 , , , cord-335975-m6lkrehi 1438 19 using use VBG cord-335975-m6lkrehi 1438 20 a a DT cord-335975-m6lkrehi 1438 21 nonparametric nonparametric JJ cord-335975-m6lkrehi 1438 22 Wilcoxon Wilcoxon NNP cord-335975-m6lkrehi 1438 23 - - HYPH cord-335975-m6lkrehi 1438 24 Mann Mann NNP cord-335975-m6lkrehi 1438 25 - - HYPH cord-335975-m6lkrehi 1438 26 Whitney Whitney NNP cord-335975-m6lkrehi 1438 27 test test NN cord-335975-m6lkrehi 1438 28 . . . cord-335975-m6lkrehi 1439 1 Results result NNS cord-335975-m6lkrehi 1439 2 : : : cord-335975-m6lkrehi 1440 1 Eighty eighty CD cord-335975-m6lkrehi 1440 2 - - HYPH cord-335975-m6lkrehi 1440 3 eight eight CD cord-335975-m6lkrehi 1440 4 patients patient NNS cord-335975-m6lkrehi 1440 5 were be VBD cord-335975-m6lkrehi 1440 6 analyzed analyze VBN cord-335975-m6lkrehi 1440 7 . . . cord-335975-m6lkrehi 1441 1 The the DT cord-335975-m6lkrehi 1441 2 mean mean JJ cord-335975-m6lkrehi 1441 3 note note NN cord-335975-m6lkrehi 1441 4 in in IN cord-335975-m6lkrehi 1441 5 the the DT cord-335975-m6lkrehi 1441 6 comfort comfort NN cord-335975-m6lkrehi 1441 7 scale scale NN cord-335975-m6lkrehi 1441 8 remained remain VBD cord-335975-m6lkrehi 1441 9 unchanged unchanged JJ cord-335975-m6lkrehi 1441 10 after after IN cord-335975-m6lkrehi 1441 11 vs. vs. CC cord-335975-m6lkrehi 1441 12 before before IN cord-335975-m6lkrehi 1441 13 drain drain NN cord-335975-m6lkrehi 1441 14 removal removal NN cord-335975-m6lkrehi 1441 15 in in IN cord-335975-m6lkrehi 1441 16 patients patient NNS cord-335975-m6lkrehi 1441 17 without without IN cord-335975-m6lkrehi 1441 18 HA HA NNP cord-335975-m6lkrehi 1441 19 ( ( -LRB- cord-335975-m6lkrehi 1441 20 n n NN cord-335975-m6lkrehi 1441 21 = = SYM cord-335975-m6lkrehi 1441 22 43 43 CD cord-335975-m6lkrehi 1441 23 , , , cord-335975-m6lkrehi 1441 24 +0.04 +0.04 NNP cord-335975-m6lkrehi 1441 25 points point NNS cord-335975-m6lkrehi 1441 26 , , , cord-335975-m6lkrehi 1441 27 ± ± NNP cord-335975-m6lkrehi 1441 28 2.8 2.8 CD cord-335975-m6lkrehi 1441 29 ) ) -RRB- cord-335975-m6lkrehi 1441 30 , , , cord-335975-m6lkrehi 1441 31 while while IN cord-335975-m6lkrehi 1441 32 it -PRON- PRP cord-335975-m6lkrehi 1441 33 increased increase VBD cord-335975-m6lkrehi 1441 34 in in IN cord-335975-m6lkrehi 1441 35 patients patient NNS cord-335975-m6lkrehi 1441 36 with with IN cord-335975-m6lkrehi 1441 37 HA HA NNP cord-335975-m6lkrehi 1441 38 ( ( -LRB- cord-335975-m6lkrehi 1441 39 n n NN cord-335975-m6lkrehi 1441 40 = = SYM cord-335975-m6lkrehi 1441 41 45 45 CD cord-335975-m6lkrehi 1441 42 , , , cord-335975-m6lkrehi 1441 43 +2.07 +2.07 NNP cord-335975-m6lkrehi 1441 44 , , , cord-335975-m6lkrehi 1441 45 ± ± NNP cord-335975-m6lkrehi 1441 46 2.7 2.7 CD cord-335975-m6lkrehi 1441 47 + + CC cord-335975-m6lkrehi 1441 48 p p NN cord-335975-m6lkrehi 1441 49 = = SYM cord-335975-m6lkrehi 1441 50 0.001 0.001 CD cord-335975-m6lkrehi 1441 51 ) ) -RRB- cord-335975-m6lkrehi 1441 52 . . . cord-335975-m6lkrehi 1442 1 Using use VBG cord-335975-m6lkrehi 1442 2 our -PRON- PRP$ cord-335975-m6lkrehi 1442 3 specific specific JJ cord-335975-m6lkrehi 1442 4 five five CD cord-335975-m6lkrehi 1442 5 item item NN cord-335975-m6lkrehi 1442 6 comfort comfort NN cord-335975-m6lkrehi 1442 7 score score NN cord-335975-m6lkrehi 1442 8 , , , cord-335975-m6lkrehi 1442 9 patients patient NNS cord-335975-m6lkrehi 1442 10 and and CC cord-335975-m6lkrehi 1442 11 caregivers caregiver NNS cord-335975-m6lkrehi 1442 12 had have VBD cord-335975-m6lkrehi 1442 13 a a DT cord-335975-m6lkrehi 1442 14 comparable comparable JJ cord-335975-m6lkrehi 1442 15 level level NN cord-335975-m6lkrehi 1442 16 of of IN cord-335975-m6lkrehi 1442 17 satisfaction satisfaction NN cord-335975-m6lkrehi 1442 18 in in IN cord-335975-m6lkrehi 1442 19 HA HA NNP cord-335975-m6lkrehi 1442 20 and and CC cord-335975-m6lkrehi 1442 21 non non AFX cord-335975-m6lkrehi 1442 22 - - JJ cord-335975-m6lkrehi 1442 23 HA HA NNP cord-335975-m6lkrehi 1442 24 groups group NNS cord-335975-m6lkrehi 1442 25 ( ( -LRB- cord-335975-m6lkrehi 1442 26 Patients patient NNS cord-335975-m6lkrehi 1442 27 17.4 17.4 CD cord-335975-m6lkrehi 1442 28 20 20 CD cord-335975-m6lkrehi 1442 29 and and CC cord-335975-m6lkrehi 1442 30 16.3 16.3 CD cord-335975-m6lkrehi 1442 31 20 20 CD cord-335975-m6lkrehi 1442 32 + + SYM cord-335975-m6lkrehi 1442 33 caregivers-19 caregivers-19 CD cord-335975-m6lkrehi 1442 34 20 20 CD cord-335975-m6lkrehi 1442 35 in in IN cord-335975-m6lkrehi 1442 36 both both DT cord-335975-m6lkrehi 1442 37 ) ) -RRB- cord-335975-m6lkrehi 1442 38 . . . cord-335975-m6lkrehi 1443 1 A a DT cord-335975-m6lkrehi 1443 2 trend trend NN cord-335975-m6lkrehi 1443 3 was be VBD cord-335975-m6lkrehi 1443 4 observed observe VBN cord-335975-m6lkrehi 1443 5 in in IN cord-335975-m6lkrehi 1443 6 reduction reduction NN cord-335975-m6lkrehi 1443 7 of of IN cord-335975-m6lkrehi 1443 8 the the DT cord-335975-m6lkrehi 1443 9 consumption consumption NN cord-335975-m6lkrehi 1443 10 of of IN cord-335975-m6lkrehi 1443 11 morphine morphine NN cord-335975-m6lkrehi 1443 12 and and CC cord-335975-m6lkrehi 1443 13 Nitrous Nitrous NNP cord-335975-m6lkrehi 1443 14 Oxid Oxid NNP cord-335975-m6lkrehi 1443 15 with with IN cord-335975-m6lkrehi 1443 16 HA HA NNP cord-335975-m6lkrehi 1443 17 , , , cord-335975-m6lkrehi 1443 18 without without IN cord-335975-m6lkrehi 1443 19 altering alter VBG cord-335975-m6lkrehi 1443 20 their -PRON- PRP$ cord-335975-m6lkrehi 1443 21 comfort comfort NN cord-335975-m6lkrehi 1443 22 . . . cord-335975-m6lkrehi 1444 1 Discussion discussion NN cord-335975-m6lkrehi 1444 2 : : : cord-335975-m6lkrehi 1445 1 Despite despite IN cord-335975-m6lkrehi 1445 2 its -PRON- PRP$ cord-335975-m6lkrehi 1445 3 limitations limitation NNS cord-335975-m6lkrehi 1445 4 ( ( -LRB- cord-335975-m6lkrehi 1445 5 mainly mainly RB cord-335975-m6lkrehi 1445 6 , , , cord-335975-m6lkrehi 1445 7 its -PRON- PRP$ cord-335975-m6lkrehi 1445 8 open open JJ cord-335975-m6lkrehi 1445 9 non non JJ cord-335975-m6lkrehi 1445 10 - - JJ cord-335975-m6lkrehi 1445 11 randomized randomized JJ cord-335975-m6lkrehi 1445 12 design design NN cord-335975-m6lkrehi 1445 13 ) ) -RRB- cord-335975-m6lkrehi 1445 14 , , , cord-335975-m6lkrehi 1445 15 this this DT cord-335975-m6lkrehi 1445 16 study study NN cord-335975-m6lkrehi 1445 17 suggests suggest VBZ cord-335975-m6lkrehi 1445 18 that that IN cord-335975-m6lkrehi 1445 19 - - : cord-335975-m6lkrehi 1445 20 HA HA NNP cord-335975-m6lkrehi 1445 21 may may MD cord-335975-m6lkrehi 1445 22 be be VB cord-335975-m6lkrehi 1445 23 used use VBN cord-335975-m6lkrehi 1445 24 for for IN cord-335975-m6lkrehi 1445 25 algogenic algogenic JJ cord-335975-m6lkrehi 1445 26 procedures procedure NNS cord-335975-m6lkrehi 1445 27 and and CC cord-335975-m6lkrehi 1445 28 is be VBZ cord-335975-m6lkrehi 1445 29 willingly willingly RB cord-335975-m6lkrehi 1445 30 adopted adopt VBN cord-335975-m6lkrehi 1445 31 in in IN cord-335975-m6lkrehi 1445 32 ICU ICU NNP cord-335975-m6lkrehi 1445 33 by by IN cord-335975-m6lkrehi 1445 34 patients patient NNS cord-335975-m6lkrehi 1445 35 and and CC cord-335975-m6lkrehi 1445 36 professionals professional NNS cord-335975-m6lkrehi 1445 37 + + CC cord-335975-m6lkrehi 1445 38 specific specific JJ cord-335975-m6lkrehi 1445 39 scales scale NNS cord-335975-m6lkrehi 1445 40 scores score NNS cord-335975-m6lkrehi 1445 41 , , , cord-335975-m6lkrehi 1445 42 adapted adapt VBN cord-335975-m6lkrehi 1445 43 for for IN cord-335975-m6lkrehi 1445 44 HA HA NNP cord-335975-m6lkrehi 1445 45 , , , cord-335975-m6lkrehi 1445 46 may may MD cord-335975-m6lkrehi 1445 47 be be VB cord-335975-m6lkrehi 1445 48 useful useful JJ cord-335975-m6lkrehi 1445 49 to to TO cord-335975-m6lkrehi 1445 50 assess assess VB cord-335975-m6lkrehi 1445 51 the the DT cord-335975-m6lkrehi 1445 52 effectiveness effectiveness NN cord-335975-m6lkrehi 1445 53 + + CC cord-335975-m6lkrehi 1445 54 finally finally RB cord-335975-m6lkrehi 1445 55 , , , cord-335975-m6lkrehi 1445 56 HA HA NNP cord-335975-m6lkrehi 1445 57 seems seem VBZ cord-335975-m6lkrehi 1445 58 to to TO cord-335975-m6lkrehi 1445 59 be be VB cord-335975-m6lkrehi 1445 60 at at IN cord-335975-m6lkrehi 1445 61 least least JJS cord-335975-m6lkrehi 1445 62 as as RB cord-335975-m6lkrehi 1445 63 efficient efficient JJ cord-335975-m6lkrehi 1445 64 as as IN cord-335975-m6lkrehi 1445 65 classical classical JJ cord-335975-m6lkrehi 1445 66 procedures procedure NNS cord-335975-m6lkrehi 1445 67 and and CC cord-335975-m6lkrehi 1445 68 could could MD cord-335975-m6lkrehi 1445 69 reduce reduce VB cord-335975-m6lkrehi 1445 70 the the DT cord-335975-m6lkrehi 1445 71 use use NN cord-335975-m6lkrehi 1445 72 of of IN cord-335975-m6lkrehi 1445 73 analgesic analgesic JJ cord-335975-m6lkrehi 1445 74 drugs drug NNS cord-335975-m6lkrehi 1445 75 . . . cord-335975-m6lkrehi 1446 1 Conclusion conclusion NN cord-335975-m6lkrehi 1446 2 : : : cord-335975-m6lkrehi 1447 1 HA HA NNP cord-335975-m6lkrehi 1447 2 adds add VBZ cord-335975-m6lkrehi 1447 3 value value NN cord-335975-m6lkrehi 1447 4 to to IN cord-335975-m6lkrehi 1447 5 patients patient NNS cord-335975-m6lkrehi 1447 6 and and CC cord-335975-m6lkrehi 1447 7 to to IN cord-335975-m6lkrehi 1447 8 all all DT cord-335975-m6lkrehi 1447 9 caregivers caregiver NNS cord-335975-m6lkrehi 1447 10 . . . cord-335975-m6lkrehi 1448 1 Prospective prospective JJ cord-335975-m6lkrehi 1448 2 randomized randomized JJ cord-335975-m6lkrehi 1448 3 studies study NNS cord-335975-m6lkrehi 1448 4 are be VBP cord-335975-m6lkrehi 1448 5 needed need VBN cord-335975-m6lkrehi 1448 6 to to TO cord-335975-m6lkrehi 1448 7 valid valid VB cord-335975-m6lkrehi 1448 8 the the DT cord-335975-m6lkrehi 1448 9 comfort comfort NN cord-335975-m6lkrehi 1448 10 scores score NNS cord-335975-m6lkrehi 1448 11 we -PRON- PRP cord-335975-m6lkrehi 1448 12 proposed propose VBD cord-335975-m6lkrehi 1448 13 , , , cord-335975-m6lkrehi 1448 14 and and CC cord-335975-m6lkrehi 1448 15 to to TO cord-335975-m6lkrehi 1448 16 prove prove VB cord-335975-m6lkrehi 1448 17 that that IN cord-335975-m6lkrehi 1448 18 HA HA NNP cord-335975-m6lkrehi 1448 19 reduces reduce VBZ cord-335975-m6lkrehi 1448 20 the the DT cord-335975-m6lkrehi 1448 21 consumption consumption NN cord-335975-m6lkrehi 1448 22 of of IN cord-335975-m6lkrehi 1448 23 analgesic analgesic JJ cord-335975-m6lkrehi 1448 24 drugs drug NNS cord-335975-m6lkrehi 1448 25 . . . cord-335975-m6lkrehi 1449 1 Introduction introduction NN cord-335975-m6lkrehi 1449 2 : : : cord-335975-m6lkrehi 1450 1 Pain pain NN cord-335975-m6lkrehi 1450 2 has have VBZ cord-335975-m6lkrehi 1450 3 long long RB cord-335975-m6lkrehi 1450 4 been be VBN cord-335975-m6lkrehi 1450 5 a a DT cord-335975-m6lkrehi 1450 6 focus focus NN cord-335975-m6lkrehi 1450 7 of of IN cord-335975-m6lkrehi 1450 8 concern concern NN cord-335975-m6lkrehi 1450 9 for for IN cord-335975-m6lkrehi 1450 10 doctors doctor NNS cord-335975-m6lkrehi 1450 11 and and CC cord-335975-m6lkrehi 1450 12 caregivers caregiver NNS cord-335975-m6lkrehi 1450 13 . . . cord-335975-m6lkrehi 1451 1 In in IN cord-335975-m6lkrehi 1451 2 intensive intensive JJ cord-335975-m6lkrehi 1451 3 care care NN cord-335975-m6lkrehi 1451 4 unit unit NN cord-335975-m6lkrehi 1451 5 , , , cord-335975-m6lkrehi 1451 6 the the DT cord-335975-m6lkrehi 1451 7 inability inability NN cord-335975-m6lkrehi 1451 8 to to TO cord-335975-m6lkrehi 1451 9 verbalize verbalize VB cord-335975-m6lkrehi 1451 10 discomfort discomfort NN cord-335975-m6lkrehi 1451 11 and and CC cord-335975-m6lkrehi 1451 12 pain pain NN cord-335975-m6lkrehi 1451 13 are be VBP cord-335975-m6lkrehi 1451 14 major major JJ cord-335975-m6lkrehi 1451 15 stressors stressor NNS cord-335975-m6lkrehi 1451 16 for for IN cord-335975-m6lkrehi 1451 17 patients patient NNS cord-335975-m6lkrehi 1451 18 . . . cord-335975-m6lkrehi 1452 1 Music music NN cord-335975-m6lkrehi 1452 2 therapy therapy NN cord-335975-m6lkrehi 1452 3 has have VBZ cord-335975-m6lkrehi 1452 4 demonstrated demonstrate VBN cord-335975-m6lkrehi 1452 5 in in IN cord-335975-m6lkrehi 1452 6 many many JJ cord-335975-m6lkrehi 1452 7 international international JJ cord-335975-m6lkrehi 1452 8 studies study NNS cord-335975-m6lkrehi 1452 9 its -PRON- PRP$ cord-335975-m6lkrehi 1452 10 effect effect NN cord-335975-m6lkrehi 1452 11 on on IN cord-335975-m6lkrehi 1452 12 the the DT cord-335975-m6lkrehi 1452 13 blood blood NN cord-335975-m6lkrehi 1452 14 pressure pressure NN cord-335975-m6lkrehi 1452 15 and and CC cord-335975-m6lkrehi 1452 16 on on IN cord-335975-m6lkrehi 1452 17 the the DT cord-335975-m6lkrehi 1452 18 respiratory respiratory JJ cord-335975-m6lkrehi 1452 19 frequency frequency NN cord-335975-m6lkrehi 1452 20 . . . cord-335975-m6lkrehi 1453 1 In in IN cord-335975-m6lkrehi 1453 2 this this DT cord-335975-m6lkrehi 1453 3 context context NN cord-335975-m6lkrehi 1453 4 , , , cord-335975-m6lkrehi 1453 5 we -PRON- PRP cord-335975-m6lkrehi 1453 6 conducted conduct VBD cord-335975-m6lkrehi 1453 7 a a DT cord-335975-m6lkrehi 1453 8 study study NN cord-335975-m6lkrehi 1453 9 to to TO cord-335975-m6lkrehi 1453 10 evaluate evaluate VB cord-335975-m6lkrehi 1453 11 the the DT cord-335975-m6lkrehi 1453 12 effects effect NNS cord-335975-m6lkrehi 1453 13 of of IN cord-335975-m6lkrehi 1453 14 standardized standardized JJ cord-335975-m6lkrehi 1453 15 musical musical JJ cord-335975-m6lkrehi 1453 16 intervention intervention NN cord-335975-m6lkrehi 1453 17 on on IN cord-335975-m6lkrehi 1453 18 pain pain NN cord-335975-m6lkrehi 1453 19 during during IN cord-335975-m6lkrehi 1453 20 painful painful JJ cord-335975-m6lkrehi 1453 21 cares care NNS cord-335975-m6lkrehi 1453 22 in in IN cord-335975-m6lkrehi 1453 23 vigils vigil NNS cord-335975-m6lkrehi 1453 24 patients patient NNS cord-335975-m6lkrehi 1453 25 hospitalized hospitalize VBN cord-335975-m6lkrehi 1453 26 in in IN cord-335975-m6lkrehi 1453 27 critical critical JJ cord-335975-m6lkrehi 1453 28 care care NN cord-335975-m6lkrehi 1453 29 . . . cord-335975-m6lkrehi 1454 1 Patients patient NNS cord-335975-m6lkrehi 1454 2 and and CC cord-335975-m6lkrehi 1454 3 methods method NNS cord-335975-m6lkrehi 1455 1 : : : cord-335975-m6lkrehi 1455 2 Design design NN cord-335975-m6lkrehi 1455 3 - - : cord-335975-m6lkrehi 1455 4 We -PRON- PRP cord-335975-m6lkrehi 1455 5 conduct conduct VBP cord-335975-m6lkrehi 1455 6 a a DT cord-335975-m6lkrehi 1455 7 prospective prospective JJ cord-335975-m6lkrehi 1455 8 , , , cord-335975-m6lkrehi 1455 9 observational observational JJ cord-335975-m6lkrehi 1455 10 , , , cord-335975-m6lkrehi 1455 11 randomised randomised JJ cord-335975-m6lkrehi 1455 12 , , , cord-335975-m6lkrehi 1455 13 single single JJ cord-335975-m6lkrehi 1455 14 blind blind JJ cord-335975-m6lkrehi 1455 15 , , , cord-335975-m6lkrehi 1455 16 mono mono NNP cord-335975-m6lkrehi 1455 17 center center NNP cord-335975-m6lkrehi 1455 18 study study NN cord-335975-m6lkrehi 1455 19 . . . cord-335975-m6lkrehi 1456 1 140 140 CD cord-335975-m6lkrehi 1456 2 painful painful JJ cord-335975-m6lkrehi 1456 3 cares care NNS cord-335975-m6lkrehi 1456 4 were be VBD cord-335975-m6lkrehi 1456 5 studied study VBN cord-335975-m6lkrehi 1456 6 and and CC cord-335975-m6lkrehi 1456 7 then then RB cord-335975-m6lkrehi 1456 8 distributed distribute VBD cord-335975-m6lkrehi 1456 9 in in IN cord-335975-m6lkrehi 1456 10 two two CD cord-335975-m6lkrehi 1456 11 groups group NNS cord-335975-m6lkrehi 1456 12 ( ( -LRB- cord-335975-m6lkrehi 1456 13 n n NN cord-335975-m6lkrehi 1456 14 = = SYM cord-335975-m6lkrehi 1456 15 70 70 CD cord-335975-m6lkrehi 1456 16 with with IN cord-335975-m6lkrehi 1456 17 music music NN cord-335975-m6lkrehi 1456 18 , , , cord-335975-m6lkrehi 1456 19 n n NN cord-335975-m6lkrehi 1456 20 = = SYM cord-335975-m6lkrehi 1456 21 70 70 CD cord-335975-m6lkrehi 1456 22 without without IN cord-335975-m6lkrehi 1456 23 music music NN cord-335975-m6lkrehi 1456 24 ) ) -RRB- cord-335975-m6lkrehi 1456 25 . . . cord-335975-m6lkrehi 1457 1 The the DT cord-335975-m6lkrehi 1457 2 patients patient NNS cord-335975-m6lkrehi 1457 3 were be VBD cord-335975-m6lkrehi 1457 4 equiped equip VBN cord-335975-m6lkrehi 1457 5 with with IN cord-335975-m6lkrehi 1457 6 a a DT cord-335975-m6lkrehi 1457 7 Bose Bose NNP cord-335975-m6lkrehi 1457 8 © © NN cord-335975-m6lkrehi 1457 9 helmet helmet NN cord-335975-m6lkrehi 1457 10 , , , cord-335975-m6lkrehi 1457 11 and and CC cord-335975-m6lkrehi 1457 12 had have VBD cord-335975-m6lkrehi 1457 13 or or CC cord-335975-m6lkrehi 1457 14 not not RB cord-335975-m6lkrehi 1457 15 music music NN cord-335975-m6lkrehi 1457 16 therapy therapy NN cord-335975-m6lkrehi 1457 17 during during IN cord-335975-m6lkrehi 1457 18 the the DT cord-335975-m6lkrehi 1457 19 care care NN cord-335975-m6lkrehi 1457 20 . . . cord-335975-m6lkrehi 1458 1 Our -PRON- PRP$ cord-335975-m6lkrehi 1458 2 main main JJ cord-335975-m6lkrehi 1458 3 criteria criterion NNS cord-335975-m6lkrehi 1458 4 was be VBD cord-335975-m6lkrehi 1458 5 the the DT cord-335975-m6lkrehi 1458 6 pain pain NN cord-335975-m6lkrehi 1458 7 , , , cord-335975-m6lkrehi 1458 8 it -PRON- PRP cord-335975-m6lkrehi 1458 9 has have VBZ cord-335975-m6lkrehi 1458 10 been be VBN cord-335975-m6lkrehi 1458 11 evaluated evaluate VBN cord-335975-m6lkrehi 1458 12 by by IN cord-335975-m6lkrehi 1458 13 a a DT cord-335975-m6lkrehi 1458 14 numeric numeric JJ cord-335975-m6lkrehi 1458 15 scale scale NN cord-335975-m6lkrehi 1458 16 before before IN cord-335975-m6lkrehi 1458 17 and and CC cord-335975-m6lkrehi 1458 18 after after IN cord-335975-m6lkrehi 1458 19 the the DT cord-335975-m6lkrehi 1458 20 painful painful JJ cord-335975-m6lkrehi 1458 21 care care NN cord-335975-m6lkrehi 1458 22 . . . cord-335975-m6lkrehi 1459 1 We -PRON- PRP cord-335975-m6lkrehi 1459 2 also also RB cord-335975-m6lkrehi 1459 3 estimated estimate VBD cord-335975-m6lkrehi 1459 4 anxiety anxiety NN cord-335975-m6lkrehi 1459 5 with with IN cord-335975-m6lkrehi 1459 6 the the DT cord-335975-m6lkrehi 1459 7 COVI COVI NNP cord-335975-m6lkrehi 1459 8 's 's POS cord-335975-m6lkrehi 1459 9 heteroevaluation heteroevaluation NN cord-335975-m6lkrehi 1459 10 scale scale NN cord-335975-m6lkrehi 1459 11 before before IN cord-335975-m6lkrehi 1459 12 and and CC cord-335975-m6lkrehi 1459 13 after after IN cord-335975-m6lkrehi 1459 14 the the DT cord-335975-m6lkrehi 1459 15 car car NN cord-335975-m6lkrehi 1459 16 . . . cord-335975-m6lkrehi 1460 1 We -PRON- PRP cord-335975-m6lkrehi 1460 2 also also RB cord-335975-m6lkrehi 1460 3 noticed notice VBD cord-335975-m6lkrehi 1460 4 if if IN cord-335975-m6lkrehi 1460 5 the the DT cord-335975-m6lkrehi 1460 6 care care NN cord-335975-m6lkrehi 1460 7 were be VBD cord-335975-m6lkrehi 1460 8 stopped stop VBN cord-335975-m6lkrehi 1460 9 because because IN cord-335975-m6lkrehi 1460 10 of of IN cord-335975-m6lkrehi 1460 11 the the DT cord-335975-m6lkrehi 1460 12 pain pain NN cord-335975-m6lkrehi 1460 13 , , , cord-335975-m6lkrehi 1460 14 then then RB cord-335975-m6lkrehi 1460 15 we -PRON- PRP cord-335975-m6lkrehi 1460 16 used use VBD cord-335975-m6lkrehi 1460 17 a a DT cord-335975-m6lkrehi 1460 18 semi semi JJ cord-335975-m6lkrehi 1460 19 quantative quantative JJ cord-335975-m6lkrehi 1460 20 numeric numeric JJ cord-335975-m6lkrehi 1460 21 scale scale NN cord-335975-m6lkrehi 1460 22 in in IN cord-335975-m6lkrehi 1460 23 order order NN cord-335975-m6lkrehi 1460 24 to to TO cord-335975-m6lkrehi 1460 25 estimate estimate VB cord-335975-m6lkrehi 1460 26 the the DT cord-335975-m6lkrehi 1460 27 feeling feeling NN cord-335975-m6lkrehi 1460 28 of of IN cord-335975-m6lkrehi 1460 29 the the DT cord-335975-m6lkrehi 1460 30 caregiver caregiver NN cord-335975-m6lkrehi 1460 31 and and CC cord-335975-m6lkrehi 1460 32 the the DT cord-335975-m6lkrehi 1460 33 patient patient NN cord-335975-m6lkrehi 1460 34 on on IN cord-335975-m6lkrehi 1460 35 the the DT cord-335975-m6lkrehi 1460 36 session session NN cord-335975-m6lkrehi 1460 37 . . . cord-335975-m6lkrehi 1461 1 Results result NNS cord-335975-m6lkrehi 1461 2 : : : cord-335975-m6lkrehi 1462 1 Concerning concern VBG cord-335975-m6lkrehi 1462 2 pain pain NN cord-335975-m6lkrehi 1462 3 , , , cord-335975-m6lkrehi 1462 4 there there EX cord-335975-m6lkrehi 1462 5 is be VBZ cord-335975-m6lkrehi 1462 6 no no DT cord-335975-m6lkrehi 1462 7 significant significant JJ cord-335975-m6lkrehi 1462 8 difference difference NN cord-335975-m6lkrehi 1462 9 between between IN cord-335975-m6lkrehi 1462 10 the the DT cord-335975-m6lkrehi 1462 11 two two CD cord-335975-m6lkrehi 1462 12 groups group NNS cord-335975-m6lkrehi 1462 13 ( ( -LRB- cord-335975-m6lkrehi 1462 14 p p NN cord-335975-m6lkrehi 1462 15 > > XX cord-335975-m6lkrehi 1462 16 0.005 0.005 CD cord-335975-m6lkrehi 1462 17 ) ) -RRB- cord-335975-m6lkrehi 1462 18 . . . cord-335975-m6lkrehi 1463 1 However however RB cord-335975-m6lkrehi 1463 2 , , , cord-335975-m6lkrehi 1463 3 in in IN cord-335975-m6lkrehi 1463 4 the the DT cord-335975-m6lkrehi 1463 5 music music NN cord-335975-m6lkrehi 1463 6 group group NN cord-335975-m6lkrehi 1463 7 , , , cord-335975-m6lkrehi 1463 8 pain pain NN cord-335975-m6lkrehi 1463 9 decreased decrease VBD cord-335975-m6lkrehi 1463 10 by by IN cord-335975-m6lkrehi 1463 11 35 35 CD cord-335975-m6lkrehi 1463 12 % % NN cord-335975-m6lkrehi 1463 13 after after IN cord-335975-m6lkrehi 1463 14 the the DT cord-335975-m6lkrehi 1463 15 care care NN cord-335975-m6lkrehi 1463 16 ( ( -LRB- cord-335975-m6lkrehi 1463 17 p p NN cord-335975-m6lkrehi 1463 18 < < XX cord-335975-m6lkrehi 1463 19 0.001 0.001 CD cord-335975-m6lkrehi 1463 20 ) ) -RRB- cord-335975-m6lkrehi 1463 21 . . . cord-335975-m6lkrehi 1464 1 Anxiety anxiety NN cord-335975-m6lkrehi 1464 2 was be VBD cord-335975-m6lkrehi 1464 3 way way RB cord-335975-m6lkrehi 1464 4 lower low JJR cord-335975-m6lkrehi 1464 5 in in IN cord-335975-m6lkrehi 1464 6 the the DT cord-335975-m6lkrehi 1464 7 music music NN cord-335975-m6lkrehi 1464 8 group group NN cord-335975-m6lkrehi 1464 9 than than IN cord-335975-m6lkrehi 1464 10 in in IN cord-335975-m6lkrehi 1464 11 the the DT cord-335975-m6lkrehi 1464 12 group group NN cord-335975-m6lkrehi 1464 13 without without IN cord-335975-m6lkrehi 1464 14 music music NN cord-335975-m6lkrehi 1464 15 ( ( -LRB- cord-335975-m6lkrehi 1464 16 p p NN cord-335975-m6lkrehi 1464 17 < < XX cord-335975-m6lkrehi 1464 18 0.001 0.001 CD cord-335975-m6lkrehi 1464 19 ) ) -RRB- cord-335975-m6lkrehi 1464 20 . . . cord-335975-m6lkrehi 1465 1 We -PRON- PRP cord-335975-m6lkrehi 1465 2 also also RB cord-335975-m6lkrehi 1465 3 noticed notice VBD cord-335975-m6lkrehi 1465 4 a a DT cord-335975-m6lkrehi 1465 5 decrease decrease NN cord-335975-m6lkrehi 1465 6 of of IN cord-335975-m6lkrehi 1465 7 50 50 CD cord-335975-m6lkrehi 1465 8 % % NN cord-335975-m6lkrehi 1465 9 of of IN cord-335975-m6lkrehi 1465 10 the the DT cord-335975-m6lkrehi 1465 11 anxiety anxiety NN cord-335975-m6lkrehi 1465 12 in in IN cord-335975-m6lkrehi 1465 13 the the DT cord-335975-m6lkrehi 1465 14 music music NN cord-335975-m6lkrehi 1465 15 group group NN cord-335975-m6lkrehi 1465 16 . . . cord-335975-m6lkrehi 1466 1 The the DT cord-335975-m6lkrehi 1466 2 patients patient NNS cord-335975-m6lkrehi 1466 3 and and CC cord-335975-m6lkrehi 1466 4 the the DT cord-335975-m6lkrehi 1466 5 caregivers caregiver NNS cord-335975-m6lkrehi 1466 6 ' ' POS cord-335975-m6lkrehi 1466 7 feeling feeling NN cord-335975-m6lkrehi 1466 8 were be VBD cord-335975-m6lkrehi 1466 9 the the DT cord-335975-m6lkrehi 1466 10 same same JJ cord-335975-m6lkrehi 1466 11 in in IN cord-335975-m6lkrehi 1466 12 the the DT cord-335975-m6lkrehi 1466 13 two two CD cord-335975-m6lkrehi 1466 14 groups group NNS cord-335975-m6lkrehi 1466 15 , , , cord-335975-m6lkrehi 1466 16 with with IN cord-335975-m6lkrehi 1466 17 no no DT cord-335975-m6lkrehi 1466 18 significant significant JJ cord-335975-m6lkrehi 1466 19 difference difference NN cord-335975-m6lkrehi 1466 20 ( ( -LRB- cord-335975-m6lkrehi 1466 21 p p NN cord-335975-m6lkrehi 1466 22 > > XX cord-335975-m6lkrehi 1466 23 0.05 0.05 CD cord-335975-m6lkrehi 1466 24 ) ) -RRB- cord-335975-m6lkrehi 1466 25 . . . cord-335975-m6lkrehi 1467 1 On on IN cord-335975-m6lkrehi 1467 2 the the DT cord-335975-m6lkrehi 1467 3 other other JJ cord-335975-m6lkrehi 1467 4 hand hand NN cord-335975-m6lkrehi 1467 5 , , , cord-335975-m6lkrehi 1467 6 caregivers caregiver NNS cord-335975-m6lkrehi 1467 7 tended tend VBD cord-335975-m6lkrehi 1467 8 to to TO cord-335975-m6lkrehi 1467 9 underestimate underestimate VB cord-335975-m6lkrehi 1467 10 the the DT cord-335975-m6lkrehi 1467 11 difficulty difficulty NN cord-335975-m6lkrehi 1467 12 of of IN cord-335975-m6lkrehi 1467 13 the the DT cord-335975-m6lkrehi 1467 14 session session NN cord-335975-m6lkrehi 1467 15 in in IN cord-335975-m6lkrehi 1467 16 comparison comparison NN cord-335975-m6lkrehi 1467 17 with with IN cord-335975-m6lkrehi 1467 18 the the DT cord-335975-m6lkrehi 1467 19 patients patient NNS cord-335975-m6lkrehi 1467 20 ' ' '' cord-335975-m6lkrehi 1467 21 ( ( -LRB- cord-335975-m6lkrehi 1467 22 p p NN cord-335975-m6lkrehi 1467 23 < < XX cord-335975-m6lkrehi 1467 24 0.01 0.01 CD cord-335975-m6lkrehi 1467 25 ) ) -RRB- cord-335975-m6lkrehi 1467 26 in in IN cord-335975-m6lkrehi 1467 27 both both DT cord-335975-m6lkrehi 1467 28 groups group NNS cord-335975-m6lkrehi 1467 29 . . . cord-335975-m6lkrehi 1468 1 Conclusion conclusion NN cord-335975-m6lkrehi 1468 2 : : : cord-335975-m6lkrehi 1469 1 Music music NN cord-335975-m6lkrehi 1469 2 therapy therapy NN cord-335975-m6lkrehi 1469 3 did do VBD cord-335975-m6lkrehi 1469 4 not not RB cord-335975-m6lkrehi 1469 5 improve improve VB cord-335975-m6lkrehi 1469 6 the the DT cord-335975-m6lkrehi 1469 7 pain pain NN cord-335975-m6lkrehi 1469 8 in in IN cord-335975-m6lkrehi 1469 9 a a DT cord-335975-m6lkrehi 1469 10 significant significant JJ cord-335975-m6lkrehi 1469 11 way way NN cord-335975-m6lkrehi 1469 12 , , , cord-335975-m6lkrehi 1469 13 in in IN cord-335975-m6lkrehi 1469 14 the the DT cord-335975-m6lkrehi 1469 15 music music NN cord-335975-m6lkrehi 1469 16 group group NN cord-335975-m6lkrehi 1469 17 versus versus IN cord-335975-m6lkrehi 1469 18 the the DT cord-335975-m6lkrehi 1469 19 group group NN cord-335975-m6lkrehi 1469 20 without without IN cord-335975-m6lkrehi 1469 21 but but CC cord-335975-m6lkrehi 1469 22 allowed allow VBD cord-335975-m6lkrehi 1469 23 a a DT cord-335975-m6lkrehi 1469 24 decrease decrease NN cord-335975-m6lkrehi 1469 25 of of IN cord-335975-m6lkrehi 1469 26 35 35 CD cord-335975-m6lkrehi 1469 27 % % NN cord-335975-m6lkrehi 1469 28 of of IN cord-335975-m6lkrehi 1469 29 the the DT cord-335975-m6lkrehi 1469 30 pain pain NN cord-335975-m6lkrehi 1469 31 after after IN cord-335975-m6lkrehi 1469 32 the the DT cord-335975-m6lkrehi 1469 33 care care NN cord-335975-m6lkrehi 1469 34 . . . cord-335975-m6lkrehi 1470 1 Nevertheless nevertheless RB cord-335975-m6lkrehi 1470 2 , , , cord-335975-m6lkrehi 1470 3 music music NN cord-335975-m6lkrehi 1470 4 reduced reduce VBN cord-335975-m6lkrehi 1470 5 by by IN cord-335975-m6lkrehi 1470 6 two two CD cord-335975-m6lkrehi 1470 7 patients'anxiety patients'anxiety NNS cord-335975-m6lkrehi 1470 8 . . . cord-335975-m6lkrehi 1471 1 Introduction introduction NN cord-335975-m6lkrehi 1471 2 : : : cord-335975-m6lkrehi 1472 1 Sedation sedation NN cord-335975-m6lkrehi 1472 2 and and CC cord-335975-m6lkrehi 1472 3 analgesia analgesia NN cord-335975-m6lkrehi 1472 4 is be VBZ cord-335975-m6lkrehi 1472 5 one one CD cord-335975-m6lkrehi 1472 6 of of IN cord-335975-m6lkrehi 1472 7 the the DT cord-335975-m6lkrehi 1472 8 basic basic JJ cord-335975-m6lkrehi 1472 9 themes theme NNS cord-335975-m6lkrehi 1472 10 in in IN cord-335975-m6lkrehi 1472 11 ICU ICU NNP cord-335975-m6lkrehi 1472 12 as as IN cord-335975-m6lkrehi 1472 13 complications complication NNS cord-335975-m6lkrehi 1472 14 associated associate VBN cord-335975-m6lkrehi 1472 15 with with IN cord-335975-m6lkrehi 1472 16 excessive excessive JJ cord-335975-m6lkrehi 1472 17 sedation sedation NN cord-335975-m6lkrehi 1472 18 negatively negatively RB cord-335975-m6lkrehi 1472 19 impact impact VB cord-335975-m6lkrehi 1472 20 the the DT cord-335975-m6lkrehi 1472 21 morbidity morbidity NN cord-335975-m6lkrehi 1472 22 and and CC cord-335975-m6lkrehi 1472 23 mortality mortality NN cord-335975-m6lkrehi 1472 24 of of IN cord-335975-m6lkrehi 1472 25 patients patient NNS cord-335975-m6lkrehi 1472 26 . . . cord-335975-m6lkrehi 1473 1 The the DT cord-335975-m6lkrehi 1473 2 objective objective NN cord-335975-m6lkrehi 1473 3 of of IN cord-335975-m6lkrehi 1473 4 this this DT cord-335975-m6lkrehi 1473 5 study study NN cord-335975-m6lkrehi 1473 6 is be VBZ cord-335975-m6lkrehi 1473 7 to to TO cord-335975-m6lkrehi 1473 8 show show VB cord-335975-m6lkrehi 1473 9 that that IN cord-335975-m6lkrehi 1473 10 the the DT cord-335975-m6lkrehi 1473 11 nurse nurse NN cord-335975-m6lkrehi 1473 12 implementation implementation NN cord-335975-m6lkrehi 1473 13 of of IN cord-335975-m6lkrehi 1473 14 a a DT cord-335975-m6lkrehi 1473 15 sedation sedation NN cord-335975-m6lkrehi 1473 16 and and CC cord-335975-m6lkrehi 1473 17 analgesia analgesia NN cord-335975-m6lkrehi 1473 18 algorithm algorithm NN cord-335975-m6lkrehi 1473 19 is be VBZ cord-335975-m6lkrehi 1473 20 beneficial beneficial JJ cord-335975-m6lkrehi 1473 21 to to IN cord-335975-m6lkrehi 1473 22 the the DT cord-335975-m6lkrehi 1473 23 patient patient NN cord-335975-m6lkrehi 1473 24 in in IN cord-335975-m6lkrehi 1473 25 terms term NNS cord-335975-m6lkrehi 1473 26 of of IN cord-335975-m6lkrehi 1473 27 sedative sedative JJ cord-335975-m6lkrehi 1473 28 drugs drug NNS cord-335975-m6lkrehi 1473 29 reduction reduction NN cord-335975-m6lkrehi 1473 30 and and CC cord-335975-m6lkrehi 1473 31 thus thus RB cord-335975-m6lkrehi 1473 32 overall overall JJ cord-335975-m6lkrehi 1473 33 decrease decrease NN cord-335975-m6lkrehi 1473 34 in in IN cord-335975-m6lkrehi 1473 35 duration duration NN cord-335975-m6lkrehi 1473 36 of of IN cord-335975-m6lkrehi 1473 37 mechanical mechanical JJ cord-335975-m6lkrehi 1473 38 ventilation ventilation NN cord-335975-m6lkrehi 1473 39 ( ( -LRB- cord-335975-m6lkrehi 1473 40 MV MV NNP cord-335975-m6lkrehi 1473 41 ) ) -RRB- cord-335975-m6lkrehi 1473 42 and and CC cord-335975-m6lkrehi 1473 43 the the DT cord-335975-m6lkrehi 1473 44 morbidity morbidity NN cord-335975-m6lkrehi 1473 45 and and CC cord-335975-m6lkrehi 1473 46 mortality mortality NN cord-335975-m6lkrehi 1473 47 which which WDT cord-335975-m6lkrehi 1473 48 is be VBZ cord-335975-m6lkrehi 1473 49 associated associate VBN cord-335975-m6lkrehi 1473 50 with with IN cord-335975-m6lkrehi 1473 51 it -PRON- PRP cord-335975-m6lkrehi 1473 52 , , , cord-335975-m6lkrehi 1473 53 without without IN cord-335975-m6lkrehi 1473 54 altering alter VBG cord-335975-m6lkrehi 1473 55 patient patient JJ cord-335975-m6lkrehi 1473 56 comfort comfort NN cord-335975-m6lkrehi 1473 57 and and CC cord-335975-m6lkrehi 1473 58 tolerance tolerance NN cord-335975-m6lkrehi 1473 59 of of IN cord-335975-m6lkrehi 1473 60 the the DT cord-335975-m6lkrehi 1473 61 environment environment NN cord-335975-m6lkrehi 1473 62 . . . cord-335975-m6lkrehi 1474 1 Patients patient NNS cord-335975-m6lkrehi 1474 2 and and CC cord-335975-m6lkrehi 1474 3 methods method NNS cord-335975-m6lkrehi 1474 4 : : : cord-335975-m6lkrehi 1474 5 A a NN cord-335975-m6lkrehi 1474 6 before before RB cord-335975-m6lkrehi 1474 7 and and CC cord-335975-m6lkrehi 1474 8 after after IN cord-335975-m6lkrehi 1474 9 prospective prospective JJ cord-335975-m6lkrehi 1474 10 , , , cord-335975-m6lkrehi 1474 11 observational observational JJ cord-335975-m6lkrehi 1474 12 , , , cord-335975-m6lkrehi 1474 13 non non JJ cord-335975-m6lkrehi 1474 14 - - JJ cord-335975-m6lkrehi 1474 15 interventional interventional JJ cord-335975-m6lkrehi 1474 16 study study NN cord-335975-m6lkrehi 1474 17 was be VBD cord-335975-m6lkrehi 1474 18 conducted conduct VBN cord-335975-m6lkrehi 1474 19 in in IN cord-335975-m6lkrehi 1474 20 surgical surgical JJ cord-335975-m6lkrehi 1474 21 ICU ICU NNP cord-335975-m6lkrehi 1474 22 in in IN cord-335975-m6lkrehi 1474 23 Caen Caen NNP cord-335975-m6lkrehi 1474 24 University University NNP cord-335975-m6lkrehi 1474 25 Hospital Hospital NNP cord-335975-m6lkrehi 1474 26 , , , cord-335975-m6lkrehi 1474 27 between between IN cord-335975-m6lkrehi 1474 28 November November NNP cord-335975-m6lkrehi 1474 29 2014 2014 CD cord-335975-m6lkrehi 1474 30 and and CC cord-335975-m6lkrehi 1474 31 April April NNP cord-335975-m6lkrehi 1474 32 2017 2017 CD cord-335975-m6lkrehi 1474 33 . . . cord-335975-m6lkrehi 1475 1 Mechanically mechanically RB cord-335975-m6lkrehi 1475 2 ventilated ventilate VBN cord-335975-m6lkrehi 1475 3 patients patient NNS cord-335975-m6lkrehi 1475 4 under under IN cord-335975-m6lkrehi 1475 5 sedation sedation NN cord-335975-m6lkrehi 1475 6 predicted predict VBN cord-335975-m6lkrehi 1475 7 to to TO cord-335975-m6lkrehi 1475 8 last last VB cord-335975-m6lkrehi 1475 9 48 48 CD cord-335975-m6lkrehi 1475 10 h h NN cord-335975-m6lkrehi 1475 11 or or CC cord-335975-m6lkrehi 1475 12 more more JJR cord-335975-m6lkrehi 1475 13 were be VBD cord-335975-m6lkrehi 1475 14 included include VBN cord-335975-m6lkrehi 1475 15 . . . cord-335975-m6lkrehi 1476 1 During during IN cord-335975-m6lkrehi 1476 2 the the DT cord-335975-m6lkrehi 1476 3 " " `` cord-335975-m6lkrehi 1476 4 Before before IN cord-335975-m6lkrehi 1476 5 " " '' cord-335975-m6lkrehi 1476 6 period period NN cord-335975-m6lkrehi 1476 7 , , , cord-335975-m6lkrehi 1476 8 sedation sedation NN cord-335975-m6lkrehi 1476 9 and and CC cord-335975-m6lkrehi 1476 10 analgesia analgesia NN cord-335975-m6lkrehi 1476 11 was be VBD cord-335975-m6lkrehi 1476 12 managed manage VBN cord-335975-m6lkrehi 1476 13 by by IN cord-335975-m6lkrehi 1476 14 the the DT cord-335975-m6lkrehi 1476 15 physician physician NN cord-335975-m6lkrehi 1476 16 , , , cord-335975-m6lkrehi 1476 17 while while IN cord-335975-m6lkrehi 1476 18 during during IN cord-335975-m6lkrehi 1476 19 the the DT cord-335975-m6lkrehi 1476 20 " " `` cord-335975-m6lkrehi 1476 21 After after IN cord-335975-m6lkrehi 1476 22 " " '' cord-335975-m6lkrehi 1476 23 period period NN cord-335975-m6lkrehi 1476 24 , , , cord-335975-m6lkrehi 1476 25 it -PRON- PRP cord-335975-m6lkrehi 1476 26 was be VBD cord-335975-m6lkrehi 1476 27 managed manage VBN cord-335975-m6lkrehi 1476 28 by by IN cord-335975-m6lkrehi 1476 29 the the DT cord-335975-m6lkrehi 1476 30 nurses nurse NNS cord-335975-m6lkrehi 1476 31 according accord VBG cord-335975-m6lkrehi 1476 32 to to IN cord-335975-m6lkrehi 1476 33 the the DT cord-335975-m6lkrehi 1476 34 protocol protocol NN cord-335975-m6lkrehi 1476 35 . . . cord-335975-m6lkrehi 1477 1 Results result NNS cord-335975-m6lkrehi 1477 2 : : : cord-335975-m6lkrehi 1477 3 1156 1156 CD cord-335975-m6lkrehi 1478 1 intubated intubate VBN cord-335975-m6lkrehi 1478 2 and and CC cord-335975-m6lkrehi 1478 3 mechanically mechanically RB cord-335975-m6lkrehi 1478 4 ventilated ventilate VBN cord-335975-m6lkrehi 1478 5 patients patient NNS cord-335975-m6lkrehi 1478 6 were be VBD cord-335975-m6lkrehi 1478 7 admitted admit VBN cord-335975-m6lkrehi 1478 8 during during IN cord-335975-m6lkrehi 1478 9 the the DT cord-335975-m6lkrehi 1478 10 study study NN cord-335975-m6lkrehi 1478 11 period period NN cord-335975-m6lkrehi 1478 12 . . . cord-335975-m6lkrehi 1479 1 Among among IN cord-335975-m6lkrehi 1479 2 the the DT cord-335975-m6lkrehi 1479 3 145 145 CD cord-335975-m6lkrehi 1479 4 eligible eligible JJ cord-335975-m6lkrehi 1479 5 patients patient NNS cord-335975-m6lkrehi 1479 6 , , , cord-335975-m6lkrehi 1479 7 100 100 CD cord-335975-m6lkrehi 1479 8 were be VBD cord-335975-m6lkrehi 1479 9 included include VBN cord-335975-m6lkrehi 1479 10 during during IN cord-335975-m6lkrehi 1479 11 " " `` cord-335975-m6lkrehi 1479 12 Before before IN cord-335975-m6lkrehi 1479 13 " " '' cord-335975-m6lkrehi 1479 14 period period NN cord-335975-m6lkrehi 1479 15 and and CC cord-335975-m6lkrehi 1479 16 45 45 CD cord-335975-m6lkrehi 1479 17 during during IN cord-335975-m6lkrehi 1479 18 " " `` cord-335975-m6lkrehi 1479 19 After after IN cord-335975-m6lkrehi 1479 20 " " '' cord-335975-m6lkrehi 1479 21 period period NN cord-335975-m6lkrehi 1479 22 . . . cord-335975-m6lkrehi 1480 1 The the DT cord-335975-m6lkrehi 1480 2 duration duration NN cord-335975-m6lkrehi 1480 3 of of IN cord-335975-m6lkrehi 1480 4 MV MV NNP cord-335975-m6lkrehi 1480 5 after after IN cord-335975-m6lkrehi 1480 6 inclusion inclusion NN cord-335975-m6lkrehi 1480 7 was be VBD cord-335975-m6lkrehi 1480 8 significantly significantly RB cord-335975-m6lkrehi 1480 9 shorter short JJR cord-335975-m6lkrehi 1480 10 in in IN cord-335975-m6lkrehi 1480 11 group group NN cord-335975-m6lkrehi 1480 12 " " `` cord-335975-m6lkrehi 1480 13 After after IN cord-335975-m6lkrehi 1480 14 " " '' cord-335975-m6lkrehi 1480 15 ( ( -LRB- cord-335975-m6lkrehi 1480 16 10.5 10.5 CD cord-335975-m6lkrehi 1480 17 [ [ -LRB- cord-335975-m6lkrehi 1480 18 7 7 CD cord-335975-m6lkrehi 1480 19 + + SYM cord-335975-m6lkrehi 1480 20 18 18 CD cord-335975-m6lkrehi 1480 21 ] ] -RRB- cord-335975-m6lkrehi 1480 22 vs vs IN cord-335975-m6lkrehi 1480 23 8 8 CD cord-335975-m6lkrehi 1480 24 [ [ -LRB- cord-335975-m6lkrehi 1480 25 5 5 CD cord-335975-m6lkrehi 1480 26 + + SYM cord-335975-m6lkrehi 1480 27 11.5 11.5 CD cord-335975-m6lkrehi 1480 28 ] ] -RRB- cord-335975-m6lkrehi 1480 29 days day NNS cord-335975-m6lkrehi 1480 30 , , , cord-335975-m6lkrehi 1480 31 p p NN cord-335975-m6lkrehi 1480 32 = = SYM cord-335975-m6lkrehi 1480 33 0.042 0.042 CD cord-335975-m6lkrehi 1480 34 ) ) -RRB- cord-335975-m6lkrehi 1480 35 , , , cord-335975-m6lkrehi 1480 36 as as IN cord-335975-m6lkrehi 1480 37 the the DT cord-335975-m6lkrehi 1480 38 duration duration NN cord-335975-m6lkrehi 1480 39 of of IN cord-335975-m6lkrehi 1480 40 target target NN cord-335975-m6lkrehi 1480 41 RASS RASS NNP cord-335975-m6lkrehi 1480 42 ( ( -LRB- cord-335975-m6lkrehi 1480 43 -2 -2 FW cord-335975-m6lkrehi 1480 44 à à NN cord-335975-m6lkrehi 1480 45 0 0 CD cord-335975-m6lkrehi 1480 46 ) ) -RRB- cord-335975-m6lkrehi 1480 47 was be VBD cord-335975-m6lkrehi 1480 48 significantly significantly RB cord-335975-m6lkrehi 1480 49 longer long JJR cord-335975-m6lkrehi 1481 1 ( ( -LRB- cord-335975-m6lkrehi 1481 2 The the DT cord-335975-m6lkrehi 1481 3 patients patient NNS cord-335975-m6lkrehi 1481 4 experienced experience VBD cord-335975-m6lkrehi 1481 5 less less JJR cord-335975-m6lkrehi 1481 6 of of IN cord-335975-m6lkrehi 1481 7 ventilator ventilator NN cord-335975-m6lkrehi 1481 8 - - HYPH cord-335975-m6lkrehi 1481 9 acquired acquire VBN cord-335975-m6lkrehi 1481 10 pneumonia pneumonia NN cord-335975-m6lkrehi 1481 11 ( ( -LRB- cord-335975-m6lkrehi 1481 12 VAP VAP NNP cord-335975-m6lkrehi 1481 13 ) ) -RRB- cord-335975-m6lkrehi 1481 14 and and CC cord-335975-m6lkrehi 1481 15 delirium delirium NN cord-335975-m6lkrehi 1481 16 during during IN cord-335975-m6lkrehi 1481 17 the the DT cord-335975-m6lkrehi 1481 18 " " `` cord-335975-m6lkrehi 1481 19 After after IN cord-335975-m6lkrehi 1481 20 " " '' cord-335975-m6lkrehi 1481 21 period period NN cord-335975-m6lkrehi 1481 22 ( ( -LRB- cord-335975-m6lkrehi 1481 23 55 55 CD cord-335975-m6lkrehi 1481 24 vs vs IN cord-335975-m6lkrehi 1481 25 24.4 24.4 CD cord-335975-m6lkrehi 1481 26 % % NN cord-335975-m6lkrehi 1481 27 , , , cord-335975-m6lkrehi 1481 28 p p NN cord-335975-m6lkrehi 1481 29 = = SYM cord-335975-m6lkrehi 1481 30 0.004 0.004 CD cord-335975-m6lkrehi 1481 31 , , , cord-335975-m6lkrehi 1481 32 and and CC cord-335975-m6lkrehi 1481 33 41 41 CD cord-335975-m6lkrehi 1481 34 vs vs IN cord-335975-m6lkrehi 1481 35 26.7 26.7 CD cord-335975-m6lkrehi 1481 36 % % NN cord-335975-m6lkrehi 1481 37 , , , cord-335975-m6lkrehi 1481 38 p p NN cord-335975-m6lkrehi 1481 39 = = SYM cord-335975-m6lkrehi 1481 40 0.015 0.015 CD cord-335975-m6lkrehi 1481 41 , , , cord-335975-m6lkrehi 1481 42 respectively respectively RB cord-335975-m6lkrehi 1481 43 ) ) -RRB- cord-335975-m6lkrehi 1481 44 . . . cord-335975-m6lkrehi 1482 1 The the DT cord-335975-m6lkrehi 1482 2 nurse nurse NN cord-335975-m6lkrehi 1482 3 implementation implementation NN cord-335975-m6lkrehi 1482 4 of of IN cord-335975-m6lkrehi 1482 5 a a DT cord-335975-m6lkrehi 1482 6 sedation sedation NN cord-335975-m6lkrehi 1482 7 and and CC cord-335975-m6lkrehi 1482 8 analgesia analgesia NN cord-335975-m6lkrehi 1482 9 algorithm algorithm NN cord-335975-m6lkrehi 1482 10 was be VBD cord-335975-m6lkrehi 1482 11 associated associate VBN cord-335975-m6lkrehi 1482 12 with with IN cord-335975-m6lkrehi 1482 13 a a DT cord-335975-m6lkrehi 1482 14 trend trend NN cord-335975-m6lkrehi 1482 15 towards towards IN cord-335975-m6lkrehi 1482 16 reduction reduction NN cord-335975-m6lkrehi 1482 17 in in IN cord-335975-m6lkrehi 1482 18 duration duration NN cord-335975-m6lkrehi 1482 19 of of IN cord-335975-m6lkrehi 1482 20 MV MV NNP cord-335975-m6lkrehi 1482 21 , , , cord-335975-m6lkrehi 1482 22 ICU ICU NNP cord-335975-m6lkrehi 1482 23 and and CC cord-335975-m6lkrehi 1482 24 hospital hospital NN cord-335975-m6lkrehi 1482 25 length length NN cord-335975-m6lkrehi 1482 26 of of IN cord-335975-m6lkrehi 1482 27 stay stay NN cord-335975-m6lkrehi 1482 28 . . . cord-335975-m6lkrehi 1483 1 Moreover moreover RB cord-335975-m6lkrehi 1483 2 , , , cord-335975-m6lkrehi 1483 3 prevalence prevalence NN cord-335975-m6lkrehi 1483 4 of of IN cord-335975-m6lkrehi 1483 5 VAP VAP NNP cord-335975-m6lkrehi 1483 6 and and CC cord-335975-m6lkrehi 1483 7 delirium delirium NN cord-335975-m6lkrehi 1483 8 was be VBD cord-335975-m6lkrehi 1483 9 reduced reduce VBN cord-335975-m6lkrehi 1483 10 , , , cord-335975-m6lkrehi 1483 11 in in IN cord-335975-m6lkrehi 1483 12 correlation correlation NN cord-335975-m6lkrehi 1483 13 to to IN cord-335975-m6lkrehi 1483 14 the the DT cord-335975-m6lkrehi 1483 15 significant significant JJ cord-335975-m6lkrehi 1483 16 decrease decrease NN cord-335975-m6lkrehi 1483 17 in in IN cord-335975-m6lkrehi 1483 18 sedative sedative JJ cord-335975-m6lkrehi 1483 19 drugs drug NNS cord-335975-m6lkrehi 1483 20 . . . cord-335975-m6lkrehi 1484 1 This this DT cord-335975-m6lkrehi 1484 2 type type NN cord-335975-m6lkrehi 1484 3 of of IN cord-335975-m6lkrehi 1484 4 algorithm algorithm NN cord-335975-m6lkrehi 1484 5 is be VBZ cord-335975-m6lkrehi 1484 6 necessary necessary JJ cord-335975-m6lkrehi 1484 7 to to TO cord-335975-m6lkrehi 1484 8 reduce reduce VB cord-335975-m6lkrehi 1484 9 morbidity morbidity NN cord-335975-m6lkrehi 1484 10 and and CC cord-335975-m6lkrehi 1484 11 mortality mortality NN cord-335975-m6lkrehi 1484 12 associated associate VBN cord-335975-m6lkrehi 1484 13 with with IN cord-335975-m6lkrehi 1484 14 MV MV NNP cord-335975-m6lkrehi 1484 15 . . . cord-335975-m6lkrehi 1485 1 Introduction introduction NN cord-335975-m6lkrehi 1485 2 : : : cord-335975-m6lkrehi 1486 1 Central central JJ cord-335975-m6lkrehi 1486 2 venous venous JJ cord-335975-m6lkrehi 1486 3 catheter catheter NN cord-335975-m6lkrehi 1486 4 insertion insertion NN cord-335975-m6lkrehi 1486 5 is be VBZ cord-335975-m6lkrehi 1486 6 a a DT cord-335975-m6lkrehi 1486 7 common common JJ cord-335975-m6lkrehi 1486 8 practice practice NN cord-335975-m6lkrehi 1486 9 for for IN cord-335975-m6lkrehi 1486 10 anesthetists anesthetist NNS cord-335975-m6lkrehi 1486 11 and and CC cord-335975-m6lkrehi 1486 12 intensivsts intensivst NNS cord-335975-m6lkrehi 1486 13 . . . cord-335975-m6lkrehi 1487 1 This this DT cord-335975-m6lkrehi 1487 2 invasive invasive JJ cord-335975-m6lkrehi 1487 3 procedure procedure NN cord-335975-m6lkrehi 1487 4 generates generate VBZ cord-335975-m6lkrehi 1487 5 pain pain NN cord-335975-m6lkrehi 1487 6 and and CC cord-335975-m6lkrehi 1487 7 anxiety anxiety NN cord-335975-m6lkrehi 1487 8 for for IN cord-335975-m6lkrehi 1487 9 patients patient NNS cord-335975-m6lkrehi 1487 10 . . . cord-335975-m6lkrehi 1488 1 We -PRON- PRP cord-335975-m6lkrehi 1488 2 aim aim VBP cord-335975-m6lkrehi 1488 3 to to TO cord-335975-m6lkrehi 1488 4 demonstrate demonstrate VB cord-335975-m6lkrehi 1488 5 that that IN cord-335975-m6lkrehi 1488 6 remifentanil remifentanil NN cord-335975-m6lkrehi 1488 7 improves improve VBZ cord-335975-m6lkrehi 1488 8 the the DT cord-335975-m6lkrehi 1488 9 analgesia analgesia NN cord-335975-m6lkrehi 1488 10 during during IN cord-335975-m6lkrehi 1488 11 scheduled schedule VBN cord-335975-m6lkrehi 1488 12 central central JJ cord-335975-m6lkrehi 1488 13 venous venous JJ cord-335975-m6lkrehi 1488 14 catheter catheter NN cord-335975-m6lkrehi 1488 15 insertion insertion NN cord-335975-m6lkrehi 1488 16 in in IN cord-335975-m6lkrehi 1488 17 mindful mindful JJ cord-335975-m6lkrehi 1488 18 patients patient NNS cord-335975-m6lkrehi 1488 19 . . . cord-335975-m6lkrehi 1489 1 Patients patient NNS cord-335975-m6lkrehi 1489 2 and and CC cord-335975-m6lkrehi 1489 3 methods method NNS cord-335975-m6lkrehi 1489 4 : : : cord-335975-m6lkrehi 1489 5 A a DT cord-335975-m6lkrehi 1489 6 prospective prospective JJ cord-335975-m6lkrehi 1489 7 , , , cord-335975-m6lkrehi 1489 8 randomized randomized JJ cord-335975-m6lkrehi 1489 9 , , , cord-335975-m6lkrehi 1489 10 double double JJ cord-335975-m6lkrehi 1489 11 - - HYPH cord-335975-m6lkrehi 1489 12 blind blind JJ cord-335975-m6lkrehi 1489 13 , , , cord-335975-m6lkrehi 1489 14 controlled controlled JJ cord-335975-m6lkrehi 1489 15 study study NN cord-335975-m6lkrehi 1489 16 in in IN cord-335975-m6lkrehi 1489 17 patients patient NNS cord-335975-m6lkrehi 1489 18 requiring require VBG cord-335975-m6lkrehi 1489 19 central central JJ cord-335975-m6lkrehi 1489 20 venous venous JJ cord-335975-m6lkrehi 1489 21 access access NN cord-335975-m6lkrehi 1489 22 . . . cord-335975-m6lkrehi 1490 1 Patients patient NNS cord-335975-m6lkrehi 1490 2 were be VBD cord-335975-m6lkrehi 1490 3 randomly randomly RB cord-335975-m6lkrehi 1490 4 assigned assign VBN cord-335975-m6lkrehi 1490 5 to to TO cord-335975-m6lkrehi 1490 6 receive receive VB cord-335975-m6lkrehi 1490 7 3 3 CD cord-335975-m6lkrehi 1490 8 ng ng NN cord-335975-m6lkrehi 1490 9 ml ml NN cord-335975-m6lkrehi 1490 10 −1 −1 NNP cord-335975-m6lkrehi 1490 11 remifentanil remifentanil NN cord-335975-m6lkrehi 1490 12 target target NN cord-335975-m6lkrehi 1490 13 controlled control VBN cord-335975-m6lkrehi 1490 14 infusion infusion NN cord-335975-m6lkrehi 1490 15 ( ( -LRB- cord-335975-m6lkrehi 1490 16 TCI TCI NNP cord-335975-m6lkrehi 1490 17 ) ) -RRB- cord-335975-m6lkrehi 1490 18 and and CC cord-335975-m6lkrehi 1490 19 local local JJ cord-335975-m6lkrehi 1490 20 anesthesia anesthesia NN cord-335975-m6lkrehi 1490 21 ( ( -LRB- cord-335975-m6lkrehi 1490 22 LA LA NNP cord-335975-m6lkrehi 1490 23 ) ) -RRB- cord-335975-m6lkrehi 1490 24 with with IN cord-335975-m6lkrehi 1490 25 lidocaine lidocaine NN cord-335975-m6lkrehi 1490 26 or or CC cord-335975-m6lkrehi 1490 27 placebo placebo NN cord-335975-m6lkrehi 1490 28 and and CC cord-335975-m6lkrehi 1490 29 LA LA NNP cord-335975-m6lkrehi 1490 30 . . . cord-335975-m6lkrehi 1491 1 All all DT cord-335975-m6lkrehi 1491 2 patients patient NNS cord-335975-m6lkrehi 1491 3 were be VBD cord-335975-m6lkrehi 1491 4 monitored monitor VBN cord-335975-m6lkrehi 1491 5 in in IN cord-335975-m6lkrehi 1491 6 intensive intensive JJ cord-335975-m6lkrehi 1491 7 care care NN cord-335975-m6lkrehi 1491 8 or or CC cord-335975-m6lkrehi 1491 9 postintervention postintervention NN cord-335975-m6lkrehi 1491 10 care care VBP cord-335975-m6lkrehi 1491 11 unit unit NN cord-335975-m6lkrehi 1491 12 and and CC cord-335975-m6lkrehi 1491 13 systematically systematically RB cord-335975-m6lkrehi 1491 14 received receive VBD cord-335975-m6lkrehi 1491 15 oxygen oxygen NN cord-335975-m6lkrehi 1491 16 . . . cord-335975-m6lkrehi 1492 1 Patients patient NNS cord-335975-m6lkrehi 1492 2 were be VBD cord-335975-m6lkrehi 1492 3 asked ask VBN cord-335975-m6lkrehi 1492 4 to to TO cord-335975-m6lkrehi 1492 5 assess assess VB cord-335975-m6lkrehi 1492 6 verbal verbal JJ cord-335975-m6lkrehi 1492 7 numeric numeric JJ cord-335975-m6lkrehi 1492 8 rating rating NN cord-335975-m6lkrehi 1492 9 pain pain NN cord-335975-m6lkrehi 1492 10 scale scale NN cord-335975-m6lkrehi 1492 11 ( ( -LRB- cord-335975-m6lkrehi 1492 12 VNRPS VNRPS NNP cord-335975-m6lkrehi 1492 13 ) ) -RRB- cord-335975-m6lkrehi 1492 14 during during IN cord-335975-m6lkrehi 1492 15 the the DT cord-335975-m6lkrehi 1492 16 procedure procedure NN cord-335975-m6lkrehi 1492 17 . . . cord-335975-m6lkrehi 1493 1 The the DT cord-335975-m6lkrehi 1493 2 primary primary JJ cord-335975-m6lkrehi 1493 3 outcome outcome NN cord-335975-m6lkrehi 1493 4 was be VBD cord-335975-m6lkrehi 1493 5 the the DT cord-335975-m6lkrehi 1493 6 maximal maximal JJ cord-335975-m6lkrehi 1493 7 VNRPS VNRPS NNP cord-335975-m6lkrehi 1493 8 . . . cord-335975-m6lkrehi 1494 1 Secondary secondary JJ cord-335975-m6lkrehi 1494 2 outcomes outcome NNS cord-335975-m6lkrehi 1494 3 were be VBD cord-335975-m6lkrehi 1494 4 pain pain NN cord-335975-m6lkrehi 1494 5 at at IN cord-335975-m6lkrehi 1494 6 each each DT cord-335975-m6lkrehi 1494 7 step step NN cord-335975-m6lkrehi 1494 8 , , , cord-335975-m6lkrehi 1494 9 anxiety anxiety NN cord-335975-m6lkrehi 1494 10 , , , cord-335975-m6lkrehi 1494 11 patient patient JJ cord-335975-m6lkrehi 1494 12 satisfaction satisfaction NN cord-335975-m6lkrehi 1494 13 , , , cord-335975-m6lkrehi 1494 14 operator operator NN cord-335975-m6lkrehi 1494 15 ease ease NN cord-335975-m6lkrehi 1494 16 and and CC cord-335975-m6lkrehi 1494 17 side side NN cord-335975-m6lkrehi 1494 18 effects effect NNS cord-335975-m6lkrehi 1494 19 . . . cord-335975-m6lkrehi 1495 1 Results result NNS cord-335975-m6lkrehi 1495 2 : : : cord-335975-m6lkrehi 1496 1 Ninety ninety CD cord-335975-m6lkrehi 1496 2 patients patient NNS cord-335975-m6lkrehi 1496 3 were be VBD cord-335975-m6lkrehi 1496 4 included include VBN cord-335975-m6lkrehi 1496 5 ( ( -LRB- cord-335975-m6lkrehi 1496 6 45 45 CD cord-335975-m6lkrehi 1496 7 in in IN cord-335975-m6lkrehi 1496 8 each each DT cord-335975-m6lkrehi 1496 9 group group NN cord-335975-m6lkrehi 1496 10 ) ) -RRB- cord-335975-m6lkrehi 1496 11 . . . cord-335975-m6lkrehi 1497 1 All all DT cord-335975-m6lkrehi 1497 2 patients patient NNS cord-335975-m6lkrehi 1497 3 were be VBD cord-335975-m6lkrehi 1497 4 analyzed analyze VBN cord-335975-m6lkrehi 1497 5 . . . cord-335975-m6lkrehi 1498 1 Remifentanil remifentanil NN cord-335975-m6lkrehi 1498 2 significantly significantly RB cord-335975-m6lkrehi 1498 3 reduced reduce VBD cord-335975-m6lkrehi 1498 4 maximal maximal JJ cord-335975-m6lkrehi 1498 5 pain pain NN cord-335975-m6lkrehi 1498 6 - - HYPH cord-335975-m6lkrehi 1498 7 VNRPS VNRPS NNP cord-335975-m6lkrehi 1498 8 20 20 CD cord-335975-m6lkrehi 1498 9 ( ( -LRB- cord-335975-m6lkrehi 1498 10 95 95 CD cord-335975-m6lkrehi 1498 11 % % NN cord-335975-m6lkrehi 1498 12 confidence confidence NN cord-335975-m6lkrehi 1498 13 interval interval NN cord-335975-m6lkrehi 1498 14 [ [ -LRB- cord-335975-m6lkrehi 1498 15 CI CI NNP cord-335975-m6lkrehi 1498 16 ] ] -RRB- cord-335975-m6lkrehi 1498 17 16 16 CD cord-335975-m6lkrehi 1498 18 - - SYM cord-335975-m6lkrehi 1498 19 40 40 CD cord-335975-m6lkrehi 1498 20 ) ) -RRB- cord-335975-m6lkrehi 1498 21 vs vs IN cord-335975-m6lkrehi 1498 22 50 50 CD cord-335975-m6lkrehi 1498 23 ( ( -LRB- cord-335975-m6lkrehi 1498 24 95 95 CD cord-335975-m6lkrehi 1498 25 % % NN cord-335975-m6lkrehi 1498 26 CI CI NNP cord-335975-m6lkrehi 1498 27 40 40 CD cord-335975-m6lkrehi 1498 28 - - SYM cord-335975-m6lkrehi 1498 29 60 60 CD cord-335975-m6lkrehi 1498 30 ) ) -RRB- cord-335975-m6lkrehi 1498 31 in in IN cord-335975-m6lkrehi 1498 32 the the DT cord-335975-m6lkrehi 1498 33 placebo placebo NN cord-335975-m6lkrehi 1498 34 group group NN cord-335975-m6lkrehi 1498 35 p p NN cord-335975-m6lkrehi 1498 36 = = SYM cord-335975-m6lkrehi 1498 37 0.0009 0.0009 CD cord-335975-m6lkrehi 1498 38 ( ( -LRB- cord-335975-m6lkrehi 1498 39 Table table NN cord-335975-m6lkrehi 1498 40 1 1 CD cord-335975-m6lkrehi 1498 41 ) ) -RRB- cord-335975-m6lkrehi 1498 42 . . . cord-335975-m6lkrehi 1499 1 We -PRON- PRP cord-335975-m6lkrehi 1499 2 did do VBD cord-335975-m6lkrehi 1499 3 not not RB cord-335975-m6lkrehi 1499 4 observe observe VB cord-335975-m6lkrehi 1499 5 any any DT cord-335975-m6lkrehi 1499 6 adverse adverse JJ cord-335975-m6lkrehi 1499 7 event event NN cord-335975-m6lkrehi 1499 8 during during IN cord-335975-m6lkrehi 1499 9 this this DT cord-335975-m6lkrehi 1499 10 study study NN cord-335975-m6lkrehi 1499 11 , , , cord-335975-m6lkrehi 1499 12 and and CC cord-335975-m6lkrehi 1499 13 there there EX cord-335975-m6lkrehi 1499 14 were be VBD cord-335975-m6lkrehi 1499 15 no no DT cord-335975-m6lkrehi 1499 16 significant significant JJ cord-335975-m6lkrehi 1499 17 difference difference NN cord-335975-m6lkrehi 1499 18 between between IN cord-335975-m6lkrehi 1499 19 the the DT cord-335975-m6lkrehi 1499 20 2 2 CD cord-335975-m6lkrehi 1499 21 groups group NNS cord-335975-m6lkrehi 1499 22 regarding regard VBG cord-335975-m6lkrehi 1499 23 side side NN cord-335975-m6lkrehi 1499 24 effects effect NNS cord-335975-m6lkrehi 1499 25 . . . cord-335975-m6lkrehi 1500 1 Conclusion conclusion NN cord-335975-m6lkrehi 1500 2 : : : cord-335975-m6lkrehi 1500 3 TCI TCI NNP cord-335975-m6lkrehi 1500 4 remifentanil remifentanil NN cord-335975-m6lkrehi 1500 5 is be VBZ cord-335975-m6lkrehi 1500 6 a a DT cord-335975-m6lkrehi 1500 7 safe safe JJ cord-335975-m6lkrehi 1500 8 procedure procedure NN cord-335975-m6lkrehi 1500 9 to to TO cord-335975-m6lkrehi 1500 10 reduce reduce VB cord-335975-m6lkrehi 1500 11 pain pain NN cord-335975-m6lkrehi 1500 12 during during IN cord-335975-m6lkrehi 1500 13 central central JJ cord-335975-m6lkrehi 1500 14 venous venous JJ cord-335975-m6lkrehi 1500 15 catheter catheter NN cord-335975-m6lkrehi 1500 16 insertion insertion NN cord-335975-m6lkrehi 1500 17 in in IN cord-335975-m6lkrehi 1500 18 awake awake JJ cord-335975-m6lkrehi 1500 19 patients patient NNS cord-335975-m6lkrehi 1500 20 . . . cord-335975-m6lkrehi 1501 1 Trial trial NN cord-335975-m6lkrehi 1501 2 Registration-clinicaltrials.gov Registration-clinicaltrials.gov NNP cord-335975-m6lkrehi 1501 3 Identifier-02206022 Identifier-02206022 NNP cord-335975-m6lkrehi 1501 4 , , , cord-335975-m6lkrehi 1501 5 REMIDOLCATH REMIDOLCATH NNP cord-335975-m6lkrehi 1501 6 . . . cord-335975-m6lkrehi 1502 1 Introduction introduction NN cord-335975-m6lkrehi 1502 2 : : : cord-335975-m6lkrehi 1503 1 Although although IN cord-335975-m6lkrehi 1503 2 guidelines guideline NNS cord-335975-m6lkrehi 1503 3 on on IN cord-335975-m6lkrehi 1503 4 post post JJ cord-335975-m6lkrehi 1503 5 - - JJ cord-335975-m6lkrehi 1503 6 resuscitation resuscitation JJ cord-335975-m6lkrehi 1503 7 care care NN cord-335975-m6lkrehi 1503 8 recommend recommend VBP cord-335975-m6lkrehi 1503 9 the the DT cord-335975-m6lkrehi 1503 10 use use NN cord-335975-m6lkrehi 1503 11 of of IN cord-335975-m6lkrehi 1503 12 short short JJ cord-335975-m6lkrehi 1503 13 - - HYPH cord-335975-m6lkrehi 1503 14 acting act VBG cord-335975-m6lkrehi 1503 15 agents agent NNS cord-335975-m6lkrehi 1503 16 for for IN cord-335975-m6lkrehi 1503 17 sedation sedation NN cord-335975-m6lkrehi 1503 18 during during IN cord-335975-m6lkrehi 1503 19 targeted target VBN cord-335975-m6lkrehi 1503 20 temperature temperature NN cord-335975-m6lkrehi 1503 21 management management NN cord-335975-m6lkrehi 1503 22 ( ( -LRB- cord-335975-m6lkrehi 1503 23 TTM TTM NNP cord-335975-m6lkrehi 1503 24 ) ) -RRB- cord-335975-m6lkrehi 1503 25 after after IN cord-335975-m6lkrehi 1503 26 cardiac cardiac JJ cord-335975-m6lkrehi 1503 27 arrest arrest NN cord-335975-m6lkrehi 1503 28 ( ( -LRB- cord-335975-m6lkrehi 1503 29 CA CA NNP cord-335975-m6lkrehi 1503 30 ) ) -RRB- cord-335975-m6lkrehi 1503 31 , , , cord-335975-m6lkrehi 1503 32 the the DT cord-335975-m6lkrehi 1503 33 potential potential JJ cord-335975-m6lkrehi 1503 34 interests interest NNS cord-335975-m6lkrehi 1503 35 of of IN cord-335975-m6lkrehi 1503 36 this this DT cord-335975-m6lkrehi 1503 37 strategy strategy NN cord-335975-m6lkrehi 1503 38 have have VBP cord-335975-m6lkrehi 1503 39 not not RB cord-335975-m6lkrehi 1503 40 been be VBN cord-335975-m6lkrehi 1503 41 clinically clinically RB cord-335975-m6lkrehi 1503 42 demonstrated demonstrate VBN cord-335975-m6lkrehi 1503 43 . . . cord-335975-m6lkrehi 1504 1 Patients patient NNS cord-335975-m6lkrehi 1504 2 and and CC cord-335975-m6lkrehi 1504 3 methods method NNS cord-335975-m6lkrehi 1504 4 : : : cord-335975-m6lkrehi 1504 5 Before before IN cord-335975-m6lkrehi 1504 6 - - HYPH cord-335975-m6lkrehi 1504 7 after after IN cord-335975-m6lkrehi 1504 8 study study NN cord-335975-m6lkrehi 1504 9 . . . cord-335975-m6lkrehi 1505 1 We -PRON- PRP cord-335975-m6lkrehi 1505 2 compared compare VBD cord-335975-m6lkrehi 1505 3 two two CD cord-335975-m6lkrehi 1505 4 sedation sedation NN cord-335975-m6lkrehi 1505 5 regimens regimen NNS cord-335975-m6lkrehi 1505 6 ( ( -LRB- cord-335975-m6lkrehi 1505 7 propofol propofol NN cord-335975-m6lkrehi 1505 8 - - HYPH cord-335975-m6lkrehi 1505 9 remifentanil remifentanil NN cord-335975-m6lkrehi 1505 10 , , , cord-335975-m6lkrehi 1505 11 period period NN cord-335975-m6lkrehi 1505 12 P2 P2 NNP cord-335975-m6lkrehi 1505 13 vs vs IN cord-335975-m6lkrehi 1505 14 midazolamfentanyl midazolamfentanyl NNP cord-335975-m6lkrehi 1505 15 , , , cord-335975-m6lkrehi 1505 16 period period NN cord-335975-m6lkrehi 1505 17 P1 P1 NNP cord-335975-m6lkrehi 1505 18 ) ) -RRB- cord-335975-m6lkrehi 1505 19 among among IN cord-335975-m6lkrehi 1505 20 comatose comatose JJ cord-335975-m6lkrehi 1505 21 TTM TTM NNP cord-335975-m6lkrehi 1505 22 - - HYPH cord-335975-m6lkrehi 1505 23 treated treat VBN cord-335975-m6lkrehi 1505 24 CA CA NNP cord-335975-m6lkrehi 1505 25 survivors survivor NNS cord-335975-m6lkrehi 1505 26 . . . cord-335975-m6lkrehi 1506 1 Management management NN cord-335975-m6lkrehi 1506 2 protocol protocol NN cord-335975-m6lkrehi 1506 3 , , , cord-335975-m6lkrehi 1506 4 apart apart RB cord-335975-m6lkrehi 1506 5 from from IN cord-335975-m6lkrehi 1506 6 sedation sedation NN cord-335975-m6lkrehi 1506 7 and and CC cord-335975-m6lkrehi 1506 8 neuromuscular neuromuscular NN cord-335975-m6lkrehi 1506 9 blockers blocker NNS cord-335975-m6lkrehi 1506 10 use use VBP cord-335975-m6lkrehi 1506 11 , , , cord-335975-m6lkrehi 1506 12 did do VBD cord-335975-m6lkrehi 1506 13 not not RB cord-335975-m6lkrehi 1506 14 change change VB cord-335975-m6lkrehi 1506 15 between between IN cord-335975-m6lkrehi 1506 16 the the DT cord-335975-m6lkrehi 1506 17 two two CD cord-335975-m6lkrehi 1506 18 periods period NNS cord-335975-m6lkrehi 1506 19 . . . cord-335975-m6lkrehi 1507 1 Baseline baseline JJ cord-335975-m6lkrehi 1507 2 severity severity NN cord-335975-m6lkrehi 1507 3 was be VBD cord-335975-m6lkrehi 1507 4 assessed assess VBN cord-335975-m6lkrehi 1507 5 with with IN cord-335975-m6lkrehi 1507 6 Cardiac Cardiac NNP cord-335975-m6lkrehi 1507 7 - - HYPH cord-335975-m6lkrehi 1507 8 Arrest Arrest NNP cord-335975-m6lkrehi 1507 9 - - HYPH cord-335975-m6lkrehi 1507 10 Hospital Hospital NNP cord-335975-m6lkrehi 1507 11 - - HYPH cord-335975-m6lkrehi 1507 12 Prognosis Prognosis NNP cord-335975-m6lkrehi 1507 13 ( ( -LRB- cord-335975-m6lkrehi 1507 14 CAHP CAHP NNP cord-335975-m6lkrehi 1507 15 ) ) -RRB- cord-335975-m6lkrehi 1507 16 score score NN cord-335975-m6lkrehi 1507 17 . . . cord-335975-m6lkrehi 1508 1 Time time NN cord-335975-m6lkrehi 1508 2 to to IN cord-335975-m6lkrehi 1508 3 awakening awakening NN cord-335975-m6lkrehi 1508 4 was be VBD cord-335975-m6lkrehi 1508 5 measured measure VBN cord-335975-m6lkrehi 1508 6 starting start VBG cord-335975-m6lkrehi 1508 7 from from IN cord-335975-m6lkrehi 1508 8 discontinuation discontinuation NN cord-335975-m6lkrehi 1508 9 of of IN cord-335975-m6lkrehi 1508 10 sedation sedation NN cord-335975-m6lkrehi 1508 11 at at IN cord-335975-m6lkrehi 1508 12 the the DT cord-335975-m6lkrehi 1508 13 end end NN cord-335975-m6lkrehi 1508 14 of of IN cord-335975-m6lkrehi 1508 15 rewarming rewarming NN cord-335975-m6lkrehi 1508 16 . . . cord-335975-m6lkrehi 1509 1 Awakening Awakening NNP cord-335975-m6lkrehi 1509 2 was be VBD cord-335975-m6lkrehi 1509 3 defined define VBN cord-335975-m6lkrehi 1509 4 as as IN cord-335975-m6lkrehi 1509 5 delayed delay VBN cord-335975-m6lkrehi 1509 6 when when WRB cord-335975-m6lkrehi 1509 7 it -PRON- PRP cord-335975-m6lkrehi 1509 8 occurred occur VBD cord-335975-m6lkrehi 1509 9 after after IN cord-335975-m6lkrehi 1509 10 more more JJR cord-335975-m6lkrehi 1509 11 than than IN cord-335975-m6lkrehi 1509 12 48 48 CD cord-335975-m6lkrehi 1509 13 h. h. NN cord-335975-m6lkrehi 1509 14 Results result NNS cord-335975-m6lkrehi 1509 15 : : : cord-335975-m6lkrehi 1509 16 460 460 CD cord-335975-m6lkrehi 1509 17 patients patient NNS cord-335975-m6lkrehi 1509 18 ( ( -LRB- cord-335975-m6lkrehi 1509 19 326 326 CD cord-335975-m6lkrehi 1509 20 in in IN cord-335975-m6lkrehi 1509 21 P1 P1 NNP cord-335975-m6lkrehi 1509 22 , , , cord-335975-m6lkrehi 1509 23 134 134 CD cord-335975-m6lkrehi 1509 24 in in IN cord-335975-m6lkrehi 1509 25 P2 P2 NNP cord-335975-m6lkrehi 1509 26 ) ) -RRB- cord-335975-m6lkrehi 1509 27 were be VBD cord-335975-m6lkrehi 1509 28 included include VBN cord-335975-m6lkrehi 1509 29 . . . cord-335975-m6lkrehi 1510 1 CAHP CAHP NNP cord-335975-m6lkrehi 1510 2 score score NN cord-335975-m6lkrehi 1510 3 in in IN cord-335975-m6lkrehi 1510 4 P2 P2 NNP cord-335975-m6lkrehi 1510 5 and and CC cord-335975-m6lkrehi 1510 6 P1 P1 NNP cord-335975-m6lkrehi 1510 7 did do VBD cord-335975-m6lkrehi 1510 8 not not RB cord-335975-m6lkrehi 1510 9 significantly significantly RB cord-335975-m6lkrehi 1510 10 differ differ VB cord-335975-m6lkrehi 1510 11 ( ( -LRB- cord-335975-m6lkrehi 1510 12 p p NN cord-335975-m6lkrehi 1510 13 = = SYM cord-335975-m6lkrehi 1510 14 0.93 0.93 CD cord-335975-m6lkrehi 1510 15 ) ) -RRB- cord-335975-m6lkrehi 1510 16 . . . cord-335975-m6lkrehi 1511 1 Sixty sixty CD cord-335975-m6lkrehi 1511 2 percent percent NN cord-335975-m6lkrehi 1511 3 of of IN cord-335975-m6lkrehi 1511 4 patients patient NNS cord-335975-m6lkrehi 1511 5 awoke awake VBD cord-335975-m6lkrehi 1511 6 in in IN cord-335975-m6lkrehi 1511 7 both both DT cord-335975-m6lkrehi 1511 8 periods period NNS cord-335975-m6lkrehi 1511 9 ( ( -LRB- cord-335975-m6lkrehi 1511 10 194 194 CD cord-335975-m6lkrehi 1511 11 326 326 CD cord-335975-m6lkrehi 1511 12 vs vs IN cord-335975-m6lkrehi 1511 13 81 81 CD cord-335975-m6lkrehi 1511 14 134 134 CD cord-335975-m6lkrehi 1511 15 , , , cord-335975-m6lkrehi 1511 16 p p NN cord-335975-m6lkrehi 1511 17 = = SYM cord-335975-m6lkrehi 1511 18 0.85 0.85 CD cord-335975-m6lkrehi 1511 19 ) ) -RRB- cord-335975-m6lkrehi 1511 20 . . . cord-335975-m6lkrehi 1512 1 Median median JJ cord-335975-m6lkrehi 1512 2 time time NN cord-335975-m6lkrehi 1512 3 to to IN cord-335975-m6lkrehi 1512 4 awakening awakening NN cord-335975-m6lkrehi 1512 5 was be VBD cord-335975-m6lkrehi 1512 6 2.5 2.5 CD cord-335975-m6lkrehi 1512 7 ( ( -LRB- cord-335975-m6lkrehi 1512 8 IQR IQR NNP cord-335975-m6lkrehi 1512 9 1 1 CD cord-335975-m6lkrehi 1512 10 - - SYM cord-335975-m6lkrehi 1512 11 9 9 CD cord-335975-m6lkrehi 1512 12 ) ) -RRB- cord-335975-m6lkrehi 1512 13 hours hour NNS cord-335975-m6lkrehi 1512 14 in in IN cord-335975-m6lkrehi 1512 15 P2 P2 NNP cord-335975-m6lkrehi 1512 16 vs. vs. IN cord-335975-m6lkrehi 1512 17 17 17 CD cord-335975-m6lkrehi 1513 1 ( ( -LRB- cord-335975-m6lkrehi 1513 2 IQR IQR NNP cord-335975-m6lkrehi 1513 3 7 7 CD cord-335975-m6lkrehi 1513 4 - - SYM cord-335975-m6lkrehi 1513 5 60 60 CD cord-335975-m6lkrehi 1513 6 ) ) -RRB- cord-335975-m6lkrehi 1513 7 hours hour NNS cord-335975-m6lkrehi 1513 8 in in IN cord-335975-m6lkrehi 1513 9 P1 P1 NNP cord-335975-m6lkrehi 1513 10 . . . cord-335975-m6lkrehi 1514 1 Awakening Awakening NNP cord-335975-m6lkrehi 1514 2 was be VBD cord-335975-m6lkrehi 1514 3 delayed delay VBN cord-335975-m6lkrehi 1514 4 in in IN cord-335975-m6lkrehi 1514 5 6 6 CD cord-335975-m6lkrehi 1514 6 % % NN cord-335975-m6lkrehi 1514 7 in in IN cord-335975-m6lkrehi 1514 8 P2 P2 NNP cord-335975-m6lkrehi 1514 9 vs. vs. IN cord-335975-m6lkrehi 1514 10 29 29 CD cord-335975-m6lkrehi 1514 11 % % NN cord-335975-m6lkrehi 1514 12 of of IN cord-335975-m6lkrehi 1514 13 patients patient NNS cord-335975-m6lkrehi 1514 14 in in IN cord-335975-m6lkrehi 1514 15 P1 P1 NNP cord-335975-m6lkrehi 1514 16 ( ( -LRB- cord-335975-m6lkrehi 1514 17 p p NN cord-335975-m6lkrehi 1514 18 < < XX cord-335975-m6lkrehi 1514 19 0.001 0.001 CD cord-335975-m6lkrehi 1514 20 ) ) -RRB- cord-335975-m6lkrehi 1514 21 . . . cord-335975-m6lkrehi 1515 1 After after IN cord-335975-m6lkrehi 1515 2 adjustment adjustment NN cord-335975-m6lkrehi 1515 3 , , , cord-335975-m6lkrehi 1515 4 P2 P2 NNP cord-335975-m6lkrehi 1515 5 was be VBD cord-335975-m6lkrehi 1515 6 associated associate VBN cord-335975-m6lkrehi 1515 7 with with IN cord-335975-m6lkrehi 1515 8 significantly significantly RB cord-335975-m6lkrehi 1515 9 lower low JJR cord-335975-m6lkrehi 1515 10 odds odd NNS cord-335975-m6lkrehi 1515 11 of of IN cord-335975-m6lkrehi 1515 12 delayed delay VBN cord-335975-m6lkrehi 1515 13 awakening awakening NN cord-335975-m6lkrehi 1515 14 ( ( -LRB- cord-335975-m6lkrehi 1515 15 OR OR NNP cord-335975-m6lkrehi 1515 16 0.08 0.08 CD cord-335975-m6lkrehi 1516 1 , , , cord-335975-m6lkrehi 1516 2 95 95 CD cord-335975-m6lkrehi 1516 3 % % NN cord-335975-m6lkrehi 1516 4 CI CI NNP cord-335975-m6lkrehi 1516 5 0.03 0.03 CD cord-335975-m6lkrehi 1516 6 - - SYM cord-335975-m6lkrehi 1516 7 0.2 0.2 CD cord-335975-m6lkrehi 1516 8 + + CC cord-335975-m6lkrehi 1516 9 p p NN cord-335975-m6lkrehi 1516 10 < < XX cord-335975-m6lkrehi 1516 11 0.001 0.001 CD cord-335975-m6lkrehi 1516 12 ) ) -RRB- cord-335975-m6lkrehi 1516 13 . . . cord-335975-m6lkrehi 1517 1 Patients patient NNS cord-335975-m6lkrehi 1517 2 in in IN cord-335975-m6lkrehi 1517 3 P2 P2 NNP cord-335975-m6lkrehi 1517 4 had have VBD cord-335975-m6lkrehi 1517 5 significantly significantly RB cord-335975-m6lkrehi 1517 6 more more JJR cord-335975-m6lkrehi 1517 7 ventilator ventilator NN cord-335975-m6lkrehi 1517 8 - - HYPH cord-335975-m6lkrehi 1517 9 free free JJ cord-335975-m6lkrehi 1517 10 days day NNS cord-335975-m6lkrehi 1517 11 , , , cord-335975-m6lkrehi 1517 12 and and CC cord-335975-m6lkrehi 1517 13 lower low JJR cord-335975-m6lkrehi 1517 14 catecholamine catecholamine NN cord-335975-m6lkrehi 1517 15 - - HYPH cord-335975-m6lkrehi 1517 16 free free JJ cord-335975-m6lkrehi 1517 17 days day NNS cord-335975-m6lkrehi 1517 18 between between IN cord-335975-m6lkrehi 1517 19 admission admission NN cord-335975-m6lkrehi 1517 20 and and CC cord-335975-m6lkrehi 1517 21 day day NN cord-335975-m6lkrehi 1517 22 28 28 CD cord-335975-m6lkrehi 1517 23 . . . cord-335975-m6lkrehi 1518 1 Survival survival NN cord-335975-m6lkrehi 1518 2 and and CC cord-335975-m6lkrehi 1518 3 favorable favorable JJ cord-335975-m6lkrehi 1518 4 neurologic neurologic JJ cord-335975-m6lkrehi 1518 5 outcome outcome NN cord-335975-m6lkrehi 1518 6 at at IN cord-335975-m6lkrehi 1518 7 discharge discharge NN cord-335975-m6lkrehi 1518 8 did do VBD cord-335975-m6lkrehi 1518 9 not not RB cord-335975-m6lkrehi 1518 10 differ differ VB cord-335975-m6lkrehi 1518 11 across across IN cord-335975-m6lkrehi 1518 12 periods period NNS cord-335975-m6lkrehi 1518 13 . . . cord-335975-m6lkrehi 1519 1 Time time NN cord-335975-m6lkrehi 1519 2 course course NN cord-335975-m6lkrehi 1519 3 for for IN cord-335975-m6lkrehi 1519 4 awakening awakening NN cord-335975-m6lkrehi 1519 5 according accord VBG cord-335975-m6lkrehi 1519 6 to to IN cord-335975-m6lkrehi 1519 7 sedation sedation NN cord-335975-m6lkrehi 1519 8 period period NN cord-335975-m6lkrehi 1519 9 . . . cord-335975-m6lkrehi 1520 1 These these DT cord-335975-m6lkrehi 1520 2 figures figure NNS cord-335975-m6lkrehi 1520 3 report report VBP cord-335975-m6lkrehi 1520 4 the the DT cord-335975-m6lkrehi 1520 5 time time NN cord-335975-m6lkrehi 1520 6 course course NN cord-335975-m6lkrehi 1520 7 of of IN cord-335975-m6lkrehi 1520 8 patients patient NNS cord-335975-m6lkrehi 1520 9 included include VBN cord-335975-m6lkrehi 1520 10 after after IN cord-335975-m6lkrehi 1520 11 discontinuation discontinuation NN cord-335975-m6lkrehi 1520 12 of of IN cord-335975-m6lkrehi 1520 13 sedation sedation NN cord-335975-m6lkrehi 1520 14 . . . cord-335975-m6lkrehi 1521 1 At at IN cord-335975-m6lkrehi 1521 2 each each DT cord-335975-m6lkrehi 1521 3 time time NN cord-335975-m6lkrehi 1521 4 point point NN cord-335975-m6lkrehi 1521 5 , , , cord-335975-m6lkrehi 1521 6 we -PRON- PRP cord-335975-m6lkrehi 1521 7 report report VBP cord-335975-m6lkrehi 1521 8 in in IN cord-335975-m6lkrehi 1521 9 the the DT cord-335975-m6lkrehi 1521 10 upper upper JJ cord-335975-m6lkrehi 1521 11 part part NN cord-335975-m6lkrehi 1521 12 , , , cord-335975-m6lkrehi 1521 13 proportion proportion NN cord-335975-m6lkrehi 1521 14 of of IN cord-335975-m6lkrehi 1521 15 patients patient NNS cord-335975-m6lkrehi 1521 16 awoken awake VBN cord-335975-m6lkrehi 1521 17 after after IN cord-335975-m6lkrehi 1521 18 discontinuation discontinuation NN cord-335975-m6lkrehi 1521 19 of of IN cord-335975-m6lkrehi 1521 20 sedation sedation NN cord-335975-m6lkrehi 1521 21 , , , cord-335975-m6lkrehi 1521 22 in in IN cord-335975-m6lkrehi 1521 23 the the DT cord-335975-m6lkrehi 1521 24 lower low JJR cord-335975-m6lkrehi 1521 25 part part NN cord-335975-m6lkrehi 1521 26 , , , cord-335975-m6lkrehi 1521 27 patients patient NNS cord-335975-m6lkrehi 1521 28 who who WP cord-335975-m6lkrehi 1521 29 died die VBD cord-335975-m6lkrehi 1521 30 without without IN cord-335975-m6lkrehi 1521 31 awakening awakening NN cord-335975-m6lkrehi 1521 32 , , , cord-335975-m6lkrehi 1521 33 and and CC cord-335975-m6lkrehi 1521 34 in in IN cord-335975-m6lkrehi 1521 35 the the DT cord-335975-m6lkrehi 1521 36 middle middle JJ cord-335975-m6lkrehi 1521 37 part part NN cord-335975-m6lkrehi 1521 38 ( ( -LRB- cord-335975-m6lkrehi 1521 39 in in IN cord-335975-m6lkrehi 1521 40 white white JJ cord-335975-m6lkrehi 1521 41 ) ) -RRB- cord-335975-m6lkrehi 1521 42 , , , cord-335975-m6lkrehi 1521 43 patients patient NNS cord-335975-m6lkrehi 1521 44 still still RB cord-335975-m6lkrehi 1521 45 comatose comatose JJ cord-335975-m6lkrehi 1521 46 . . . cord-335975-m6lkrehi 1522 1 Red red JJ cord-335975-m6lkrehi 1522 2 dots dot NNS cord-335975-m6lkrehi 1522 3 indicate indicate VBP cord-335975-m6lkrehi 1522 4 , , , cord-335975-m6lkrehi 1522 5 for for IN cord-335975-m6lkrehi 1522 6 each each DT cord-335975-m6lkrehi 1522 7 period period NN cord-335975-m6lkrehi 1522 8 , , , cord-335975-m6lkrehi 1522 9 the the DT cord-335975-m6lkrehi 1522 10 last last JJ cord-335975-m6lkrehi 1522 11 patient patient NN cord-335975-m6lkrehi 1522 12 awakening awakening NN cord-335975-m6lkrehi 1522 13 ( ( -LRB- cord-335975-m6lkrehi 1522 14 after after IN cord-335975-m6lkrehi 1522 15 12 12 CD cord-335975-m6lkrehi 1522 16 days day NNS cord-335975-m6lkrehi 1522 17 in in IN cord-335975-m6lkrehi 1522 18 P1 P1 NNP cord-335975-m6lkrehi 1522 19 and and CC cord-335975-m6lkrehi 1522 20 5 5 CD cord-335975-m6lkrehi 1522 21 days day NNS cord-335975-m6lkrehi 1522 22 in in IN cord-335975-m6lkrehi 1522 23 P2 P2 NNP cord-335975-m6lkrehi 1522 24 ) ) -RRB- cord-335975-m6lkrehi 1522 25 . . . cord-335975-m6lkrehi 1523 1 Black black JJ cord-335975-m6lkrehi 1523 2 dots dot NNS cord-335975-m6lkrehi 1523 3 indicate indicate VBP cord-335975-m6lkrehi 1523 4 the the DT cord-335975-m6lkrehi 1523 5 median median JJ cord-335975-m6lkrehi 1523 6 time time NN cord-335975-m6lkrehi 1523 7 to to IN cord-335975-m6lkrehi 1523 8 awakening awakening NN cord-335975-m6lkrehi 1523 9 ( ( -LRB- cord-335975-m6lkrehi 1523 10 too too RB cord-335975-m6lkrehi 1523 11 early early JJ cord-335975-m6lkrehi 1523 12 to to TO cord-335975-m6lkrehi 1523 13 appear appear VB cord-335975-m6lkrehi 1523 14 for for IN cord-335975-m6lkrehi 1523 15 period period NN cord-335975-m6lkrehi 1523 16 2 2 CD cord-335975-m6lkrehi 1523 17 ) ) -RRB- cord-335975-m6lkrehi 1523 18 . . . cord-335975-m6lkrehi 1524 1 Conclusion conclusion NN cord-335975-m6lkrehi 1524 2 : : : cord-335975-m6lkrehi 1524 3 During during IN cord-335975-m6lkrehi 1524 4 TTM TTM NNP cord-335975-m6lkrehi 1524 5 following follow VBG cord-335975-m6lkrehi 1524 6 resuscitation resuscitation NN cord-335975-m6lkrehi 1524 7 from from IN cord-335975-m6lkrehi 1524 8 CA CA NNP cord-335975-m6lkrehi 1524 9 , , , cord-335975-m6lkrehi 1524 10 sedation sedation NN cord-335975-m6lkrehi 1524 11 with with IN cord-335975-m6lkrehi 1524 12 propofol propofol NN cord-335975-m6lkrehi 1524 13 - - HYPH cord-335975-m6lkrehi 1524 14 remifentanil remifentanil NN cord-335975-m6lkrehi 1524 15 compared compare VBN cord-335975-m6lkrehi 1524 16 with with IN cord-335975-m6lkrehi 1524 17 midazolam midazolam NN cord-335975-m6lkrehi 1524 18 - - HYPH cord-335975-m6lkrehi 1524 19 fentanyl fentanyl NN cord-335975-m6lkrehi 1524 20 was be VBD cord-335975-m6lkrehi 1524 21 associated associate VBN cord-335975-m6lkrehi 1524 22 with with IN cord-335975-m6lkrehi 1524 23 an an DT cord-335975-m6lkrehi 1524 24 earlier early JJR cord-335975-m6lkrehi 1524 25 awakening awakening NN cord-335975-m6lkrehi 1524 26 , , , cord-335975-m6lkrehi 1524 27 and and CC cord-335975-m6lkrehi 1524 28 an an DT cord-335975-m6lkrehi 1524 29 increase increase NN cord-335975-m6lkrehi 1524 30 in in IN cord-335975-m6lkrehi 1524 31 ventilator ventilator NN cord-335975-m6lkrehi 1524 32 - - HYPH cord-335975-m6lkrehi 1524 33 free free JJ cord-335975-m6lkrehi 1524 34 days day NNS cord-335975-m6lkrehi 1524 35 . . . cord-335975-m6lkrehi 1525 1 The the DT cord-335975-m6lkrehi 1525 2 new new JJ cord-335975-m6lkrehi 1525 3 recommendations recommendation NNS cord-335975-m6lkrehi 1525 4 of of IN cord-335975-m6lkrehi 1525 5 the the DT cord-335975-m6lkrehi 1525 6 French french JJ cord-335975-m6lkrehi 1525 7 society society NN cord-335975-m6lkrehi 1525 8 of of IN cord-335975-m6lkrehi 1525 9 anesthesia anesthesia NN cord-335975-m6lkrehi 1525 10 - - HYPH cord-335975-m6lkrehi 1525 11 intensive intensive JJ cord-335975-m6lkrehi 1525 12 care care NN cord-335975-m6lkrehi 1525 13 ( ( -LRB- cord-335975-m6lkrehi 1525 14 SFAR SFAR NNP cord-335975-m6lkrehi 1525 15 ) ) -RRB- cord-335975-m6lkrehi 1525 16 on on IN cord-335975-m6lkrehi 1525 17 perfusion perfusion NN cord-335975-m6lkrehi 1525 18 and and CC cord-335975-m6lkrehi 1525 19 medication medication NN cord-335975-m6lkrehi 1525 20 errors error NNS cord-335975-m6lkrehi 1525 21 were be VBD cord-335975-m6lkrehi 1525 22 revised revise VBN cord-335975-m6lkrehi 1525 23 in in IN cord-335975-m6lkrehi 1525 24 2016 2016 CD cord-335975-m6lkrehi 1525 25 to to TO cord-335975-m6lkrehi 1525 26 promote promote VB cord-335975-m6lkrehi 1525 27 proper proper JJ cord-335975-m6lkrehi 1525 28 use use NN cord-335975-m6lkrehi 1525 29 relating relate VBG cord-335975-m6lkrehi 1525 30 to to IN cord-335975-m6lkrehi 1525 31 drug drug NN cord-335975-m6lkrehi 1525 32 administration administration NN cord-335975-m6lkrehi 1525 33 with with IN cord-335975-m6lkrehi 1525 34 medical medical JJ cord-335975-m6lkrehi 1525 35 devices device NNS cord-335975-m6lkrehi 1525 36 . . . cord-335975-m6lkrehi 1526 1 To to TO cord-335975-m6lkrehi 1526 2 advance advance VB cord-335975-m6lkrehi 1526 3 that that DT cord-335975-m6lkrehi 1526 4 of of IN cord-335975-m6lkrehi 1526 5 inquiry inquiry NN cord-335975-m6lkrehi 1526 6 , , , cord-335975-m6lkrehi 1526 7 practices practice NNS cord-335975-m6lkrehi 1526 8 of of IN cord-335975-m6lkrehi 1526 9 our -PRON- PRP$ cord-335975-m6lkrehi 1526 10 intensive intensive JJ cord-335975-m6lkrehi 1526 11 care care NN cord-335975-m6lkrehi 1526 12 unit unit NN cord-335975-m6lkrehi 1526 13 ( ( -LRB- cord-335975-m6lkrehi 1526 14 ICU ICU NNP cord-335975-m6lkrehi 1526 15 ) ) -RRB- cord-335975-m6lkrehi 1526 16 were be VBD cord-335975-m6lkrehi 1526 17 assessed assess VBN cord-335975-m6lkrehi 1526 18 in in IN cord-335975-m6lkrehi 1526 19 order order NN cord-335975-m6lkrehi 1526 20 to to TO cord-335975-m6lkrehi 1526 21 improve improve VB cord-335975-m6lkrehi 1526 22 drug drug NN cord-335975-m6lkrehi 1526 23 administration administration NN cord-335975-m6lkrehi 1526 24 by by IN cord-335975-m6lkrehi 1526 25 central central JJ cord-335975-m6lkrehi 1526 26 venous venous JJ cord-335975-m6lkrehi 1526 27 catheter catheter NN cord-335975-m6lkrehi 1526 28 ( ( -LRB- cord-335975-m6lkrehi 1526 29 CVC CVC NNP cord-335975-m6lkrehi 1526 30 ) ) -RRB- cord-335975-m6lkrehi 1526 31 . . . cord-335975-m6lkrehi 1527 1 Patients patient NNS cord-335975-m6lkrehi 1527 2 and and CC cord-335975-m6lkrehi 1527 3 methods method NNS cord-335975-m6lkrehi 1527 4 : : : cord-335975-m6lkrehi 1527 5 Prospective prospective JJ cord-335975-m6lkrehi 1527 6 evaluation evaluation NN cord-335975-m6lkrehi 1527 7 by by IN cord-335975-m6lkrehi 1527 8 pharmacist pharmacist NN cord-335975-m6lkrehi 1527 9 resident resident NN cord-335975-m6lkrehi 1527 10 and and CC cord-335975-m6lkrehi 1527 11 technical technical JJ cord-335975-m6lkrehi 1527 12 nurse nurse NN cord-335975-m6lkrehi 1527 13 during during IN cord-335975-m6lkrehi 1527 14 seven seven CD cord-335975-m6lkrehi 1527 15 weeks week NNS cord-335975-m6lkrehi 1527 16 , , , cord-335975-m6lkrehi 1527 17 using use VBG cord-335975-m6lkrehi 1527 18 a a DT cord-335975-m6lkrehi 1527 19 standard standard JJ cord-335975-m6lkrehi 1527 20 evaluation evaluation NN cord-335975-m6lkrehi 1527 21 tool tool NN cord-335975-m6lkrehi 1527 22 , , , cord-335975-m6lkrehi 1527 23 in in IN cord-335975-m6lkrehi 1527 24 a a DT cord-335975-m6lkrehi 1527 25 16 16 CD cord-335975-m6lkrehi 1527 26 bed bed NN cord-335975-m6lkrehi 1527 27 ICU ICU NNP cord-335975-m6lkrehi 1527 28 . . . cord-335975-m6lkrehi 1528 1 Drug drug NN cord-335975-m6lkrehi 1528 2 recommendations recommendation NNS cord-335975-m6lkrehi 1528 3 and and CC cord-335975-m6lkrehi 1528 4 SFAR SFAR NNP cord-335975-m6lkrehi 1528 5 documents document NNS cord-335975-m6lkrehi 1528 6 from from IN cord-335975-m6lkrehi 1528 7 2016 2016 CD cord-335975-m6lkrehi 1528 8 were be VBD cord-335975-m6lkrehi 1528 9 used use VBN cord-335975-m6lkrehi 1528 10 as as IN cord-335975-m6lkrehi 1528 11 referential referential JJ cord-335975-m6lkrehi 1528 12 of of IN cord-335975-m6lkrehi 1528 13 conformity conformity NN cord-335975-m6lkrehi 1528 14 . . . cord-335975-m6lkrehi 1529 1 The the DT cord-335975-m6lkrehi 1529 2 following following JJ cord-335975-m6lkrehi 1529 3 parameters parameter NNS cord-335975-m6lkrehi 1529 4 were be VBD cord-335975-m6lkrehi 1529 5 evaluated-1 evaluated-1 VBP cord-335975-m6lkrehi 1529 6 Central central JJ cord-335975-m6lkrehi 1529 7 venous venous JJ cord-335975-m6lkrehi 1529 8 lines line NNS cord-335975-m6lkrehi 1529 9 mounting mount VBG cord-335975-m6lkrehi 1529 10 , , , cord-335975-m6lkrehi 1529 11 2 2 CD cord-335975-m6lkrehi 1529 12 Drug Drug NNP cord-335975-m6lkrehi 1529 13 administration administration NN cord-335975-m6lkrehi 1529 14 and and CC cord-335975-m6lkrehi 1529 15 identification identification NN cord-335975-m6lkrehi 1529 16 with with IN cord-335975-m6lkrehi 1529 17 a a DT cord-335975-m6lkrehi 1529 18 focus focus NN cord-335975-m6lkrehi 1529 19 on on IN cord-335975-m6lkrehi 1529 20 narrow narrow JJ cord-335975-m6lkrehi 1529 21 therapeutic therapeutic JJ cord-335975-m6lkrehi 1529 22 index index NN cord-335975-m6lkrehi 1529 23 ( ( -LRB- cord-335975-m6lkrehi 1529 24 NTI NTI NNP cord-335975-m6lkrehi 1529 25 ) ) -RRB- cord-335975-m6lkrehi 1529 26 drugs drug NNS cord-335975-m6lkrehi 1529 27 . . . cord-335975-m6lkrehi 1530 1 Results result NNS cord-335975-m6lkrehi 1530 2 : : : cord-335975-m6lkrehi 1531 1 50 50 CD cord-335975-m6lkrehi 1531 2 patients patient NNS cord-335975-m6lkrehi 1531 3 with with IN cord-335975-m6lkrehi 1531 4 CVC CVC NNP cord-335975-m6lkrehi 1531 5 were be VBD cord-335975-m6lkrehi 1531 6 analyzed analyze VBN cord-335975-m6lkrehi 1531 7 between between IN cord-335975-m6lkrehi 1531 8 June June NNP cord-335975-m6lkrehi 1531 9 and and CC cord-335975-m6lkrehi 1531 10 July July NNP cord-335975-m6lkrehi 1531 11 2017 2017 CD cord-335975-m6lkrehi 1531 12 . . . cord-335975-m6lkrehi 1532 1 19 19 CD cord-335975-m6lkrehi 1532 2 entered enter VBD cord-335975-m6lkrehi 1532 3 directly directly RB cord-335975-m6lkrehi 1532 4 in in IN cord-335975-m6lkrehi 1532 5 the the DT cord-335975-m6lkrehi 1532 6 ICU ICU NNP cord-335975-m6lkrehi 1532 7 . . . cord-335975-m6lkrehi 1533 1 23 23 CD cord-335975-m6lkrehi 1533 2 were be VBD cord-335975-m6lkrehi 1533 3 hospitalized hospitalize VBN cord-335975-m6lkrehi 1533 4 for for IN cord-335975-m6lkrehi 1533 5 surgical surgical JJ cord-335975-m6lkrehi 1533 6 reasons reason NNS cord-335975-m6lkrehi 1533 7 . . . cord-335975-m6lkrehi 1534 1 42 42 CD cord-335975-m6lkrehi 1534 2 had have VBD cord-335975-m6lkrehi 1534 3 triple triple JJ cord-335975-m6lkrehi 1534 4 - - HYPH cord-335975-m6lkrehi 1534 5 lumen lumen NN cord-335975-m6lkrehi 1534 6 CVC CVC NNP cord-335975-m6lkrehi 1534 7 . . . cord-335975-m6lkrehi 1535 1 Regarding regard VBG cord-335975-m6lkrehi 1535 2 the the DT cord-335975-m6lkrehi 1535 3 first first JJ cord-335975-m6lkrehi 1535 4 parameter parameter NN cord-335975-m6lkrehi 1535 5 , , , cord-335975-m6lkrehi 1535 6 no no DT cord-335975-m6lkrehi 1535 7 conformity conformity NN cord-335975-m6lkrehi 1535 8 was be VBD cord-335975-m6lkrehi 1535 9 found find VBN cord-335975-m6lkrehi 1535 10 due due IN cord-335975-m6lkrehi 1535 11 to to IN cord-335975-m6lkrehi 1535 12 lack lack NN cord-335975-m6lkrehi 1535 13 of of IN cord-335975-m6lkrehi 1535 14 line line NN cord-335975-m6lkrehi 1535 15 identification identification NN cord-335975-m6lkrehi 1535 16 ( ( -LRB- cord-335975-m6lkrehi 1535 17 100 100 CD cord-335975-m6lkrehi 1535 18 % % NN cord-335975-m6lkrehi 1535 19 ) ) -RRB- cord-335975-m6lkrehi 1535 20 or or CC cord-335975-m6lkrehi 1535 21 anti anti JJ cord-335975-m6lkrehi 1535 22 - - JJ cord-335975-m6lkrehi 1535 23 return return JJ cord-335975-m6lkrehi 1535 24 valve valve NN cord-335975-m6lkrehi 1535 25 well well RB cord-335975-m6lkrehi 1535 26 positioned positioned JJ cord-335975-m6lkrehi 1535 27 ( ( -LRB- cord-335975-m6lkrehi 1535 28 96 96 CD cord-335975-m6lkrehi 1535 29 % % NN cord-335975-m6lkrehi 1535 30 ) ) -RRB- cord-335975-m6lkrehi 1535 31 . . . cord-335975-m6lkrehi 1536 1 Perfusion perfusion NN cord-335975-m6lkrehi 1536 2 ramp ramp NN cord-335975-m6lkrehi 1536 3 position position NN cord-335975-m6lkrehi 1536 4 was be VBD cord-335975-m6lkrehi 1536 5 above above IN cord-335975-m6lkrehi 1536 6 heart heart NN cord-335975-m6lkrehi 1536 7 level level NN cord-335975-m6lkrehi 1536 8 in in IN cord-335975-m6lkrehi 1536 9 10 10 CD cord-335975-m6lkrehi 1536 10 % % NN cord-335975-m6lkrehi 1536 11 , , , cord-335975-m6lkrehi 1536 12 infusion infusion NN cord-335975-m6lkrehi 1536 13 tubing tubing NN cord-335975-m6lkrehi 1536 14 had have VBD cord-335975-m6lkrehi 1536 15 contact contact NN cord-335975-m6lkrehi 1536 16 with with IN cord-335975-m6lkrehi 1536 17 floor floor NN cord-335975-m6lkrehi 1536 18 in in IN cord-335975-m6lkrehi 1536 19 6 6 CD cord-335975-m6lkrehi 1536 20 % % NN cord-335975-m6lkrehi 1536 21 , , , cord-335975-m6lkrehi 1536 22 and and CC cord-335975-m6lkrehi 1536 23 absence absence NN cord-335975-m6lkrehi 1536 24 of of IN cord-335975-m6lkrehi 1536 25 plug plug NN cord-335975-m6lkrehi 1536 26 on on RP cord-335975-m6lkrehi 1536 27 non non JJ cord-335975-m6lkrehi 1536 28 - - JJ cord-335975-m6lkrehi 1536 29 used used JJ cord-335975-m6lkrehi 1536 30 lines line NNS cord-335975-m6lkrehi 1536 31 is be VBZ cord-335975-m6lkrehi 1536 32 found find VBN cord-335975-m6lkrehi 1536 33 in in IN cord-335975-m6lkrehi 1536 34 8 8 CD cord-335975-m6lkrehi 1536 35 % % NN cord-335975-m6lkrehi 1536 36 of of IN cord-335975-m6lkrehi 1536 37 cases case NNS cord-335975-m6lkrehi 1536 38 . . . cord-335975-m6lkrehi 1537 1 Regarding regard VBG cord-335975-m6lkrehi 1537 2 second second JJ cord-335975-m6lkrehi 1537 3 parameter parameter NN cord-335975-m6lkrehi 1537 4 , , , cord-335975-m6lkrehi 1537 5 non non JJ cord-335975-m6lkrehi 1537 6 - - NNS cord-335975-m6lkrehi 1537 7 conformities conformity NNS cord-335975-m6lkrehi 1537 8 were be VBD cord-335975-m6lkrehi 1537 9 due due JJ cord-335975-m6lkrehi 1537 10 mostly mostly RB cord-335975-m6lkrehi 1537 11 to to TO cord-335975-m6lkrehi 1537 12 syringe syringe VB cord-335975-m6lkrehi 1537 13 label label NN cord-335975-m6lkrehi 1537 14 - - HYPH cord-335975-m6lkrehi 1537 15 absence absence NN cord-335975-m6lkrehi 1537 16 of of IN cord-335975-m6lkrehi 1537 17 drug drug NN cord-335975-m6lkrehi 1537 18 's 's POS cord-335975-m6lkrehi 1537 19 concentration concentration NN cord-335975-m6lkrehi 1537 20 ( ( -LRB- cord-335975-m6lkrehi 1537 21 72 72 CD cord-335975-m6lkrehi 1537 22 % % NN cord-335975-m6lkrehi 1537 23 ) ) -RRB- cord-335975-m6lkrehi 1537 24 , , , cord-335975-m6lkrehi 1537 25 preparator preparator NN cord-335975-m6lkrehi 1537 26 identification identification NN cord-335975-m6lkrehi 1537 27 ( ( -LRB- cord-335975-m6lkrehi 1537 28 99 99 CD cord-335975-m6lkrehi 1537 29 % % NN cord-335975-m6lkrehi 1537 30 ) ) -RRB- cord-335975-m6lkrehi 1537 31 , , , cord-335975-m6lkrehi 1537 32 patient patient JJ cord-335975-m6lkrehi 1537 33 identification identification NN cord-335975-m6lkrehi 1537 34 ( ( -LRB- cord-335975-m6lkrehi 1537 35 99.7 99.7 CD cord-335975-m6lkrehi 1537 36 % % NN cord-335975-m6lkrehi 1537 37 ) ) -RRB- cord-335975-m6lkrehi 1537 38 , , , cord-335975-m6lkrehi 1537 39 drug drug NN cord-335975-m6lkrehi 1537 40 identification identification NN cord-335975-m6lkrehi 1537 41 ( ( -LRB- cord-335975-m6lkrehi 1537 42 3.5 3.5 CD cord-335975-m6lkrehi 1537 43 % % NN cord-335975-m6lkrehi 1537 44 , , , cord-335975-m6lkrehi 1537 45 all all DT cord-335975-m6lkrehi 1537 46 concerning concern VBG cord-335975-m6lkrehi 1537 47 propofol propofol NN cord-335975-m6lkrehi 1537 48 ) ) -RRB- cord-335975-m6lkrehi 1537 49 , , , cord-335975-m6lkrehi 1537 50 date date NN cord-335975-m6lkrehi 1537 51 and and CC cord-335975-m6lkrehi 1537 52 time time NN cord-335975-m6lkrehi 1537 53 of of IN cord-335975-m6lkrehi 1537 54 medication medication NN cord-335975-m6lkrehi 1537 55 preparation preparation NN cord-335975-m6lkrehi 1537 56 ( ( -LRB- cord-335975-m6lkrehi 1537 57 67 67 CD cord-335975-m6lkrehi 1537 58 % % NN cord-335975-m6lkrehi 1537 59 ) ) -RRB- cord-335975-m6lkrehi 1537 60 , , , cord-335975-m6lkrehi 1537 61 lack lack NN cord-335975-m6lkrehi 1537 62 of of IN cord-335975-m6lkrehi 1537 63 color color NN cord-335975-m6lkrehi 1537 64 code code NN cord-335975-m6lkrehi 1537 65 of of IN cord-335975-m6lkrehi 1537 66 labels label NNS cord-335975-m6lkrehi 1537 67 ( ( -LRB- cord-335975-m6lkrehi 1537 68 100 100 CD cord-335975-m6lkrehi 1537 69 % % NN cord-335975-m6lkrehi 1537 70 ) ) -RRB- cord-335975-m6lkrehi 1537 71 . . . cord-335975-m6lkrehi 1538 1 Regarding regard VBG cord-335975-m6lkrehi 1538 2 NTI NTI NNP cord-335975-m6lkrehi 1538 3 , , , cord-335975-m6lkrehi 1538 4 70 70 CD cord-335975-m6lkrehi 1538 5 % % NN cord-335975-m6lkrehi 1538 6 were be VBD cord-335975-m6lkrehi 1538 7 not not RB cord-335975-m6lkrehi 1538 8 administrated administrate VBN cord-335975-m6lkrehi 1538 9 according accord VBG cord-335975-m6lkrehi 1538 10 to to IN cord-335975-m6lkrehi 1538 11 the the DT cord-335975-m6lkrehi 1538 12 recommendations recommendation NNS cord-335975-m6lkrehi 1538 13 - - : cord-335975-m6lkrehi 1538 14 absence absence NN cord-335975-m6lkrehi 1538 15 of of IN cord-335975-m6lkrehi 1538 16 dedicated dedicated JJ cord-335975-m6lkrehi 1538 17 line line NN cord-335975-m6lkrehi 1538 18 ( ( -LRB- cord-335975-m6lkrehi 1538 19 63 63 CD cord-335975-m6lkrehi 1538 20 % % NN cord-335975-m6lkrehi 1538 21 ) ) -RRB- cord-335975-m6lkrehi 1538 22 , , , cord-335975-m6lkrehi 1538 23 absence absence NN cord-335975-m6lkrehi 1538 24 of of IN cord-335975-m6lkrehi 1538 25 administration administration NN cord-335975-m6lkrehi 1538 26 on on IN cord-335975-m6lkrehi 1538 27 the the DT cord-335975-m6lkrehi 1538 28 nearest near JJS cord-335975-m6lkrehi 1538 29 insertion insertion NN cord-335975-m6lkrehi 1538 30 site site NN cord-335975-m6lkrehi 1538 31 of of IN cord-335975-m6lkrehi 1538 32 the the DT cord-335975-m6lkrehi 1538 33 catheter catheter NN cord-335975-m6lkrehi 1538 34 ( ( -LRB- cord-335975-m6lkrehi 1538 35 67 67 CD cord-335975-m6lkrehi 1538 36 % % NN cord-335975-m6lkrehi 1538 37 ) ) -RRB- cord-335975-m6lkrehi 1538 38 . . . cord-335975-m6lkrehi 1539 1 Conclusion conclusion NN cord-335975-m6lkrehi 1539 2 : : : cord-335975-m6lkrehi 1540 1 The the DT cord-335975-m6lkrehi 1540 2 evaluation evaluation NN cord-335975-m6lkrehi 1540 3 highlight highlight VBP cord-335975-m6lkrehi 1540 4 some some DT cord-335975-m6lkrehi 1540 5 improvement improvement NN cord-335975-m6lkrehi 1540 6 axis axis NN cord-335975-m6lkrehi 1540 7 such such JJ cord-335975-m6lkrehi 1540 8 as as IN cord-335975-m6lkrehi 1540 9 complete complete JJ cord-335975-m6lkrehi 1540 10 identification identification NN cord-335975-m6lkrehi 1540 11 on on IN cord-335975-m6lkrehi 1540 12 syringes syrinx NNS cord-335975-m6lkrehi 1540 13 , , , cord-335975-m6lkrehi 1540 14 sensitizing sensitize VBG cord-335975-m6lkrehi 1540 15 of of IN cord-335975-m6lkrehi 1540 16 ICU ICU NNP cord-335975-m6lkrehi 1540 17 healthcare healthcare NN cord-335975-m6lkrehi 1540 18 team team NN cord-335975-m6lkrehi 1540 19 , , , cord-335975-m6lkrehi 1540 20 or or CC cord-335975-m6lkrehi 1540 21 homogenization homogenization NN cord-335975-m6lkrehi 1540 22 of of IN cord-335975-m6lkrehi 1540 23 CVC CVC NNP cord-335975-m6lkrehi 1540 24 perfusion perfusion NN cord-335975-m6lkrehi 1540 25 system system NN cord-335975-m6lkrehi 1540 26 . . . cord-335975-m6lkrehi 1541 1 It -PRON- PRP cord-335975-m6lkrehi 1541 2 calls call VBZ cord-335975-m6lkrehi 1541 3 for for IN cord-335975-m6lkrehi 1541 4 a a DT cord-335975-m6lkrehi 1541 5 second second JJ cord-335975-m6lkrehi 1541 6 evaluation evaluation NN cord-335975-m6lkrehi 1541 7 round round NN cord-335975-m6lkrehi 1541 8 after after IN cord-335975-m6lkrehi 1541 9 implementation implementation NN cord-335975-m6lkrehi 1541 10 of of IN cord-335975-m6lkrehi 1541 11 improvements improvement NNS cord-335975-m6lkrehi 1541 12 . . . cord-335975-m6lkrehi 1542 1 Introduction introduction NN cord-335975-m6lkrehi 1542 2 : : : cord-335975-m6lkrehi 1543 1 Sedation sedation NN cord-335975-m6lkrehi 1543 2 is be VBZ cord-335975-m6lkrehi 1543 3 a a DT cord-335975-m6lkrehi 1543 4 corner corner NN cord-335975-m6lkrehi 1543 5 stone stone NN cord-335975-m6lkrehi 1543 6 of of IN cord-335975-m6lkrehi 1543 7 the the DT cord-335975-m6lkrehi 1543 8 care care NN cord-335975-m6lkrehi 1543 9 of of IN cord-335975-m6lkrehi 1543 10 patients patient NNS cord-335975-m6lkrehi 1543 11 receiving receive VBG cord-335975-m6lkrehi 1543 12 mechanical mechanical JJ cord-335975-m6lkrehi 1543 13 ventilation ventilation NN cord-335975-m6lkrehi 1543 14 in in IN cord-335975-m6lkrehi 1543 15 the the DT cord-335975-m6lkrehi 1543 16 ICU ICU NNP cord-335975-m6lkrehi 1543 17 . . . cord-335975-m6lkrehi 1544 1 Sedation sedation NN cord-335975-m6lkrehi 1544 2 was be VBD cord-335975-m6lkrehi 1544 3 associated associate VBN cord-335975-m6lkrehi 1544 4 with with IN cord-335975-m6lkrehi 1544 5 increased increase VBN cord-335975-m6lkrehi 1544 6 comfort comfort NN cord-335975-m6lkrehi 1544 7 and and CC cord-335975-m6lkrehi 1544 8 adherence adherence NN cord-335975-m6lkrehi 1544 9 to to TO cord-335975-m6lkrehi 1544 10 care care VB cord-335975-m6lkrehi 1544 11 , , , cord-335975-m6lkrehi 1544 12 but but CC cord-335975-m6lkrehi 1544 13 also also RB cord-335975-m6lkrehi 1544 14 with with IN cord-335975-m6lkrehi 1544 15 increased increase VBN cord-335975-m6lkrehi 1544 16 morbidity morbidity NN cord-335975-m6lkrehi 1544 17 , , , cord-335975-m6lkrehi 1544 18 including include VBG cord-335975-m6lkrehi 1544 19 delirium delirium NN cord-335975-m6lkrehi 1544 20 , , , cord-335975-m6lkrehi 1544 21 increased increase VBN cord-335975-m6lkrehi 1544 22 duration duration NN cord-335975-m6lkrehi 1544 23 of of IN cord-335975-m6lkrehi 1544 24 mechanical mechanical JJ cord-335975-m6lkrehi 1544 25 ventilation ventilation NN cord-335975-m6lkrehi 1544 26 and and CC cord-335975-m6lkrehi 1544 27 length length NN cord-335975-m6lkrehi 1544 28 of of IN cord-335975-m6lkrehi 1544 29 ICU ICU NNP cord-335975-m6lkrehi 1544 30 stay stay NN cord-335975-m6lkrehi 1544 31 . . . cord-335975-m6lkrehi 1545 1 Previous previous JJ cord-335975-m6lkrehi 1545 2 studies study NNS cord-335975-m6lkrehi 1545 3 reported report VBD cord-335975-m6lkrehi 1545 4 beneficial beneficial JJ cord-335975-m6lkrehi 1545 5 impact impact NN cord-335975-m6lkrehi 1545 6 of of IN cord-335975-m6lkrehi 1545 7 reduced reduce VBN cord-335975-m6lkrehi 1545 8 doses dose NNS cord-335975-m6lkrehi 1545 9 of of IN cord-335975-m6lkrehi 1545 10 sedative sedative JJ cord-335975-m6lkrehi 1545 11 drugs drug NNS cord-335975-m6lkrehi 1545 12 and and CC cord-335975-m6lkrehi 1545 13 careful careful JJ cord-335975-m6lkrehi 1545 14 monitoring monitoring NN cord-335975-m6lkrehi 1545 15 of of IN cord-335975-m6lkrehi 1545 16 patients patient NNS cord-335975-m6lkrehi 1545 17 comfort comfort NN cord-335975-m6lkrehi 1545 18 and and CC cord-335975-m6lkrehi 1545 19 consciousness consciousness NN cord-335975-m6lkrehi 1545 20 . . . cord-335975-m6lkrehi 1546 1 Our -PRON- PRP$ cord-335975-m6lkrehi 1546 2 goal goal NN cord-335975-m6lkrehi 1546 3 was be VBD cord-335975-m6lkrehi 1546 4 to to TO cord-335975-m6lkrehi 1546 5 assess assess VB cord-335975-m6lkrehi 1546 6 the the DT cord-335975-m6lkrehi 1546 7 impact impact NN cord-335975-m6lkrehi 1546 8 of of IN cord-335975-m6lkrehi 1546 9 the the DT cord-335975-m6lkrehi 1546 10 introduction introduction NN cord-335975-m6lkrehi 1546 11 of of IN cord-335975-m6lkrehi 1546 12 a a DT cord-335975-m6lkrehi 1546 13 nurses nurse NNS cord-335975-m6lkrehi 1546 14 - - HYPH cord-335975-m6lkrehi 1546 15 dedicated dedicated JJ cord-335975-m6lkrehi 1546 16 sedation sedation NN cord-335975-m6lkrehi 1546 17 protocol protocol NN cord-335975-m6lkrehi 1546 18 in in IN cord-335975-m6lkrehi 1546 19 our -PRON- PRP$ cord-335975-m6lkrehi 1546 20 ICU ICU NNP cord-335975-m6lkrehi 1546 21 . . . cord-335975-m6lkrehi 1547 1 Patients patient NNS cord-335975-m6lkrehi 1547 2 and and CC cord-335975-m6lkrehi 1547 3 methods method NNS cord-335975-m6lkrehi 1547 4 : : : cord-335975-m6lkrehi 1548 1 This this DT cord-335975-m6lkrehi 1548 2 monocentre monocentre NNP cord-335975-m6lkrehi 1548 3 retrospective retrospective NN cord-335975-m6lkrehi 1549 1 before before IN cord-335975-m6lkrehi 1549 2 - - HYPH cord-335975-m6lkrehi 1549 3 after after IN cord-335975-m6lkrehi 1549 4 study study NN cord-335975-m6lkrehi 1549 5 included include VBD cord-335975-m6lkrehi 1549 6 all all PDT cord-335975-m6lkrehi 1549 7 the the DT cord-335975-m6lkrehi 1549 8 patients patient NNS cord-335975-m6lkrehi 1549 9 admitted admit VBN cord-335975-m6lkrehi 1549 10 in in IN cord-335975-m6lkrehi 1549 11 our -PRON- PRP$ cord-335975-m6lkrehi 1549 12 ICU ICU NNP cord-335975-m6lkrehi 1549 13 , , , cord-335975-m6lkrehi 1549 14 over over IN cord-335975-m6lkrehi 1549 15 two two CD cord-335975-m6lkrehi 1549 16 threemonth threemonth JJ cord-335975-m6lkrehi 1549 17 periods period NNS cord-335975-m6lkrehi 1549 18 , , , cord-335975-m6lkrehi 1549 19 from from IN cord-335975-m6lkrehi 1549 20 July July NNP cord-335975-m6lkrehi 1549 21 2015 2015 CD cord-335975-m6lkrehi 1549 22 and and CC cord-335975-m6lkrehi 1549 23 January January NNP cord-335975-m6lkrehi 1549 24 2016 2016 CD cord-335975-m6lkrehi 1549 25 , , , cord-335975-m6lkrehi 1549 26 treated treat VBN cord-335975-m6lkrehi 1549 27 with with IN cord-335975-m6lkrehi 1549 28 invasive invasive JJ cord-335975-m6lkrehi 1549 29 mechanical mechanical JJ cord-335975-m6lkrehi 1549 30 ventilation ventilation NN cord-335975-m6lkrehi 1549 31 for for IN cord-335975-m6lkrehi 1549 32 more more JJR cord-335975-m6lkrehi 1549 33 than than IN cord-335975-m6lkrehi 1549 34 24 24 CD cord-335975-m6lkrehi 1549 35 h h NN cord-335975-m6lkrehi 1549 36 and and CC cord-335975-m6lkrehi 1549 37 older old JJR cord-335975-m6lkrehi 1549 38 than than IN cord-335975-m6lkrehi 1549 39 18yrs 18yrs NNP cord-335975-m6lkrehi 1549 40 . . . cord-335975-m6lkrehi 1550 1 After after IN cord-335975-m6lkrehi 1550 2 the the DT cord-335975-m6lkrehi 1550 3 first first JJ cord-335975-m6lkrehi 1550 4 period period NN cord-335975-m6lkrehi 1550 5 , , , cord-335975-m6lkrehi 1550 6 all all DT cord-335975-m6lkrehi 1550 7 physicians physician NNS cord-335975-m6lkrehi 1550 8 and and CC cord-335975-m6lkrehi 1550 9 nurses nurse NNS cord-335975-m6lkrehi 1550 10 were be VBD cord-335975-m6lkrehi 1550 11 trained train VBN cord-335975-m6lkrehi 1550 12 to to IN cord-335975-m6lkrehi 1550 13 a a DT cord-335975-m6lkrehi 1550 14 new new JJ cord-335975-m6lkrehi 1550 15 sedation sedation NN cord-335975-m6lkrehi 1550 16 management management NN cord-335975-m6lkrehi 1550 17 protocol protocol NN cord-335975-m6lkrehi 1550 18 . . . cord-335975-m6lkrehi 1551 1 Analysis analysis NN cord-335975-m6lkrehi 1551 2 was be VBD cord-335975-m6lkrehi 1551 3 performed perform VBN cord-335975-m6lkrehi 1551 4 to to TO cord-335975-m6lkrehi 1551 5 assess assess VB cord-335975-m6lkrehi 1551 6 the the DT cord-335975-m6lkrehi 1551 7 prescription prescription NN cord-335975-m6lkrehi 1551 8 and and CC cord-335975-m6lkrehi 1551 9 application application NN cord-335975-m6lkrehi 1551 10 of of IN cord-335975-m6lkrehi 1551 11 the the DT cord-335975-m6lkrehi 1551 12 protocol protocol NN cord-335975-m6lkrehi 1551 13 , , , cord-335975-m6lkrehi 1551 14 its -PRON- PRP$ cord-335975-m6lkrehi 1551 15 impact impact NN cord-335975-m6lkrehi 1551 16 on on IN cord-335975-m6lkrehi 1551 17 the the DT cord-335975-m6lkrehi 1551 18 use use NN cord-335975-m6lkrehi 1551 19 of of IN cord-335975-m6lkrehi 1551 20 sedative sedative JJ cord-335975-m6lkrehi 1551 21 drugs drug NNS cord-335975-m6lkrehi 1551 22 , , , cord-335975-m6lkrehi 1551 23 ICU ICU NNP cord-335975-m6lkrehi 1551 24 length length NN cord-335975-m6lkrehi 1551 25 of of IN cord-335975-m6lkrehi 1551 26 stay stay NN cord-335975-m6lkrehi 1551 27 , , , cord-335975-m6lkrehi 1551 28 and and CC cord-335975-m6lkrehi 1551 29 duration duration NN cord-335975-m6lkrehi 1551 30 of of IN cord-335975-m6lkrehi 1551 31 mechanical mechanical JJ cord-335975-m6lkrehi 1551 32 ventilation ventilation NN cord-335975-m6lkrehi 1551 33 . . . cord-335975-m6lkrehi 1552 1 Major major JJ cord-335975-m6lkrehi 1552 2 complications complication NNS cord-335975-m6lkrehi 1552 3 were be VBD cord-335975-m6lkrehi 1552 4 also also RB cord-335975-m6lkrehi 1552 5 recorded record VBN cord-335975-m6lkrehi 1552 6 . . . cord-335975-m6lkrehi 1553 1 Results result NNS cord-335975-m6lkrehi 1553 2 : : : cord-335975-m6lkrehi 1554 1 134 134 CD cord-335975-m6lkrehi 1554 2 patients patient NNS cord-335975-m6lkrehi 1554 3 were be VBD cord-335975-m6lkrehi 1554 4 included-78 included-78 CD cord-335975-m6lkrehi 1554 5 before before RB cord-335975-m6lkrehi 1554 6 and and CC cord-335975-m6lkrehi 1554 7 56 56 CD cord-335975-m6lkrehi 1554 8 after after IN cord-335975-m6lkrehi 1554 9 the the DT cord-335975-m6lkrehi 1554 10 protocol protocol NN cord-335975-m6lkrehi 1554 11 implementation implementation NN cord-335975-m6lkrehi 1554 12 . . . cord-335975-m6lkrehi 1555 1 Patients patient NNS cord-335975-m6lkrehi 1555 2 in in IN cord-335975-m6lkrehi 1555 3 both both DT cord-335975-m6lkrehi 1555 4 groups group NNS cord-335975-m6lkrehi 1555 5 had have VBD cord-335975-m6lkrehi 1555 6 similar similar JJ cord-335975-m6lkrehi 1555 7 baseline baseline JJ cord-335975-m6lkrehi 1555 8 characteristics characteristic NNS cord-335975-m6lkrehi 1555 9 ( ( -LRB- cord-335975-m6lkrehi 1555 10 Men man NNS cord-335975-m6lkrehi 1555 11 67 67 CD cord-335975-m6lkrehi 1555 12 vs. vs. NN cord-335975-m6lkrehi 1555 13 50 50 CD cord-335975-m6lkrehi 1555 14 % % NN cord-335975-m6lkrehi 1555 15 , , , cord-335975-m6lkrehi 1556 1 p p NN cord-335975-m6lkrehi 1556 2 = = SYM cord-335975-m6lkrehi 1556 3 0.08 0.08 CD cord-335975-m6lkrehi 1556 4 + + CC cord-335975-m6lkrehi 1556 5 mean mean VB cord-335975-m6lkrehi 1556 6 age age NN cord-335975-m6lkrehi 1556 7 56 56 CD cord-335975-m6lkrehi 1557 1 ± ± NNP cord-335975-m6lkrehi 1557 2 18 18 CD cord-335975-m6lkrehi 1557 3 vs. vs. NN cord-335975-m6lkrehi 1557 4 60 60 CD cord-335975-m6lkrehi 1557 5 ± ± NNP cord-335975-m6lkrehi 1557 6 16 16 CD cord-335975-m6lkrehi 1557 7 years year NNS cord-335975-m6lkrehi 1557 8 , , , cord-335975-m6lkrehi 1557 9 p p NN cord-335975-m6lkrehi 1557 10 = = SYM cord-335975-m6lkrehi 1557 11 0.1 0.1 CD cord-335975-m6lkrehi 1558 1 + + CC cord-335975-m6lkrehi 1558 2 weight weight NN cord-335975-m6lkrehi 1558 3 73.2 73.2 CD cord-335975-m6lkrehi 1558 4 ± ± NNP cord-335975-m6lkrehi 1558 5 20.6 20.6 CD cord-335975-m6lkrehi 1558 6 vs. vs. NN cord-335975-m6lkrehi 1558 7 70.2 70.2 CD cord-335975-m6lkrehi 1558 8 ± ± CD cord-335975-m6lkrehi 1558 9 15.9 15.9 CD cord-335975-m6lkrehi 1558 10 kg kg NNS cord-335975-m6lkrehi 1558 11 p p NN cord-335975-m6lkrehi 1559 1 = = SYM cord-335975-m6lkrehi 1559 2 0.61 0.61 CD cord-335975-m6lkrehi 1560 1 + + CC cord-335975-m6lkrehi 1561 1 IGS2 IGS2 NNP cord-335975-m6lkrehi 1561 2 44 44 CD cord-335975-m6lkrehi 1561 3 ± ± NNP cord-335975-m6lkrehi 1561 4 17 17 CD cord-335975-m6lkrehi 1561 5 vs. vs. NN cord-335975-m6lkrehi 1561 6 44 44 CD cord-335975-m6lkrehi 1561 7 ± ± CD cord-335975-m6lkrehi 1561 8 19 19 CD cord-335975-m6lkrehi 1561 9 , , , cord-335975-m6lkrehi 1561 10 p p NN cord-335975-m6lkrehi 1561 11 = = SYM cord-335975-m6lkrehi 1561 12 0.99 0.99 CD cord-335975-m6lkrehi 1561 13 + + CC cord-335975-m6lkrehi 1561 14 medical medical JJ cord-335975-m6lkrehi 1561 15 admission admission NN cord-335975-m6lkrehi 1561 16 91 91 CD cord-335975-m6lkrehi 1561 17 vs. vs. CC cord-335975-m6lkrehi 1561 18 88 88 CD cord-335975-m6lkrehi 1561 19 % % NN cord-335975-m6lkrehi 1561 20 , , , cord-335975-m6lkrehi 1561 21 p p NN cord-335975-m6lkrehi 1561 22 = = SYM cord-335975-m6lkrehi 1561 23 0.51 0.51 CD cord-335975-m6lkrehi 1561 24 ) ) -RRB- cord-335975-m6lkrehi 1561 25 . . . cord-335975-m6lkrehi 1562 1 Recordings recording NNS cord-335975-m6lkrehi 1562 2 of of IN cord-335975-m6lkrehi 1562 3 RASS RASS NNP cord-335975-m6lkrehi 1562 4 and and CC cord-335975-m6lkrehi 1562 5 BPS BPS NNP cord-335975-m6lkrehi 1562 6 did do VBD cord-335975-m6lkrehi 1562 7 not not RB cord-335975-m6lkrehi 1562 8 differ differ VB cord-335975-m6lkrehi 1562 9 between between IN cord-335975-m6lkrehi 1562 10 groups group NNS cord-335975-m6lkrehi 1562 11 ( ( -LRB- cord-335975-m6lkrehi 1562 12 9 9 CD cord-335975-m6lkrehi 1562 13 ± ± NNP cord-335975-m6lkrehi 1562 14 4 4 CD cord-335975-m6lkrehi 1562 15 vs vs IN cord-335975-m6lkrehi 1562 16 10 10 CD cord-335975-m6lkrehi 1562 17 ± ± NNP cord-335975-m6lkrehi 1562 18 9 9 CD cord-335975-m6lkrehi 1562 19 , , , cord-335975-m6lkrehi 1562 20 p p NN cord-335975-m6lkrehi 1562 21 = = SYM cord-335975-m6lkrehi 1562 22 048 048 CD cord-335975-m6lkrehi 1562 23 + + SYM cord-335975-m6lkrehi 1562 24 19 19 CD cord-335975-m6lkrehi 1562 25 ± ± CD cord-335975-m6lkrehi 1562 26 25 25 CD cord-335975-m6lkrehi 1562 27 vs vs NN cord-335975-m6lkrehi 1562 28 , , , cord-335975-m6lkrehi 1562 29 16 16 CD cord-335975-m6lkrehi 1562 30 ± ± NNP cord-335975-m6lkrehi 1562 31 11 11 CD cord-335975-m6lkrehi 1562 32 , , , cord-335975-m6lkrehi 1562 33 p p NN cord-335975-m6lkrehi 1562 34 = = SYM cord-335975-m6lkrehi 1562 35 0.25 0.25 CD cord-335975-m6lkrehi 1562 36 ) ) -RRB- cord-335975-m6lkrehi 1562 37 . . . cord-335975-m6lkrehi 1563 1 The the DT cord-335975-m6lkrehi 1563 2 duration duration NN cord-335975-m6lkrehi 1563 3 of of IN cord-335975-m6lkrehi 1563 4 sedation sedation NN cord-335975-m6lkrehi 1563 5 was be VBD cord-335975-m6lkrehi 1563 6 significantly significantly RB cord-335975-m6lkrehi 1563 7 shorter short JJR cord-335975-m6lkrehi 1563 8 after after IN cord-335975-m6lkrehi 1563 9 introduction introduction NN cord-335975-m6lkrehi 1563 10 of of IN cord-335975-m6lkrehi 1563 11 protocol protocol NN cord-335975-m6lkrehi 1563 12 ( ( -LRB- cord-335975-m6lkrehi 1563 13 4.1 4.1 CD cord-335975-m6lkrehi 1563 14 ± ± NNP cord-335975-m6lkrehi 1563 15 4.7 4.7 CD cord-335975-m6lkrehi 1563 16 vs vs IN cord-335975-m6lkrehi 1563 17 1.9 1.9 CD cord-335975-m6lkrehi 1563 18 ± ± NNP cord-335975-m6lkrehi 1563 19 1.0 1.0 CD cord-335975-m6lkrehi 1563 20 , , , cord-335975-m6lkrehi 1563 21 p p NN cord-335975-m6lkrehi 1563 22 < < XX cord-335975-m6lkrehi 1563 23 0.0001 0.0001 CD cord-335975-m6lkrehi 1563 24 ) ) -RRB- cord-335975-m6lkrehi 1563 25 , , , cord-335975-m6lkrehi 1563 26 as as IN cord-335975-m6lkrehi 1563 27 was be VBD cord-335975-m6lkrehi 1563 28 the the DT cord-335975-m6lkrehi 1563 29 duration duration NN cord-335975-m6lkrehi 1563 30 of of IN cord-335975-m6lkrehi 1563 31 mechanical mechanical JJ cord-335975-m6lkrehi 1563 32 ventilation ventilation NN cord-335975-m6lkrehi 1563 33 ( ( -LRB- cord-335975-m6lkrehi 1563 34 9.3 9.3 CD cord-335975-m6lkrehi 1563 35 ± ± CD cord-335975-m6lkrehi 1563 36 13.8 13.8 CD cord-335975-m6lkrehi 1563 37 vs vs IN cord-335975-m6lkrehi 1563 38 4.1 4.1 CD cord-335975-m6lkrehi 1563 39 ± ± CD cord-335975-m6lkrehi 1563 40 3.2 3.2 CD cord-335975-m6lkrehi 1563 41 , , , cord-335975-m6lkrehi 1563 42 p p NN cord-335975-m6lkrehi 1563 43 = = SYM cord-335975-m6lkrehi 1563 44 0.001 0.001 CD cord-335975-m6lkrehi 1563 45 ) ) -RRB- cord-335975-m6lkrehi 1563 46 and and CC cord-335975-m6lkrehi 1563 47 ICU ICU NNP cord-335975-m6lkrehi 1563 48 length length NN cord-335975-m6lkrehi 1563 49 of of IN cord-335975-m6lkrehi 1563 50 stay stay NN cord-335975-m6lkrehi 1563 51 ( ( -LRB- cord-335975-m6lkrehi 1563 52 12.3 12.3 CD cord-335975-m6lkrehi 1563 53 ± ± CD cord-335975-m6lkrehi 1563 54 15.8 15.8 CD cord-335975-m6lkrehi 1563 55 vs vs IN cord-335975-m6lkrehi 1563 56 7.3 7.3 CD cord-335975-m6lkrehi 1563 57 ± ± CD cord-335975-m6lkrehi 1563 58 5.3 5.3 CD cord-335975-m6lkrehi 1563 59 , , , cord-335975-m6lkrehi 1563 60 p p NN cord-335975-m6lkrehi 1563 61 = = SYM cord-335975-m6lkrehi 1563 62 0.028 0.028 CD cord-335975-m6lkrehi 1563 63 ) ) -RRB- cord-335975-m6lkrehi 1563 64 . . . cord-335975-m6lkrehi 1564 1 There there EX cord-335975-m6lkrehi 1564 2 was be VBD cord-335975-m6lkrehi 1564 3 no no DT cord-335975-m6lkrehi 1564 4 difference difference NN cord-335975-m6lkrehi 1564 5 in in IN cord-335975-m6lkrehi 1564 6 major major JJ cord-335975-m6lkrehi 1564 7 ICU ICU NNP cord-335975-m6lkrehi 1564 8 complications complication NNS cord-335975-m6lkrehi 1564 9 , , , cord-335975-m6lkrehi 1564 10 nor nor CC cord-335975-m6lkrehi 1564 11 in in IN cord-335975-m6lkrehi 1564 12 mortality mortality NN cord-335975-m6lkrehi 1564 13 between between IN cord-335975-m6lkrehi 1564 14 groups group NNS cord-335975-m6lkrehi 1564 15 ( ( -LRB- cord-335975-m6lkrehi 1564 16 25 25 CD cord-335975-m6lkrehi 1564 17 and and CC cord-335975-m6lkrehi 1564 18 30 30 CD cord-335975-m6lkrehi 1564 19 % % NN cord-335975-m6lkrehi 1564 20 ) ) -RRB- cord-335975-m6lkrehi 1564 21 . . . cord-335975-m6lkrehi 1565 1 Conclusion conclusion NN cord-335975-m6lkrehi 1565 2 : : : cord-335975-m6lkrehi 1566 1 Although although IN cord-335975-m6lkrehi 1566 2 the the DT cord-335975-m6lkrehi 1566 3 implantation implantation NN cord-335975-m6lkrehi 1566 4 of of IN cord-335975-m6lkrehi 1566 5 a a DT cord-335975-m6lkrehi 1566 6 sedation sedation NN cord-335975-m6lkrehi 1566 7 protocol protocol NN cord-335975-m6lkrehi 1566 8 did do VBD cord-335975-m6lkrehi 1566 9 not not RB cord-335975-m6lkrehi 1566 10 translate translate VB cord-335975-m6lkrehi 1566 11 in in IN cord-335975-m6lkrehi 1566 12 increased increase VBN cord-335975-m6lkrehi 1566 13 recording recording NN cord-335975-m6lkrehi 1566 14 of of IN cord-335975-m6lkrehi 1566 15 RASS RASS NNP cord-335975-m6lkrehi 1566 16 and and CC cord-335975-m6lkrehi 1566 17 BPS BPS NNP cord-335975-m6lkrehi 1566 18 scores score NNS cord-335975-m6lkrehi 1566 19 , , , cord-335975-m6lkrehi 1566 20 it -PRON- PRP cord-335975-m6lkrehi 1566 21 was be VBD cord-335975-m6lkrehi 1566 22 associated associate VBN cord-335975-m6lkrehi 1566 23 with with IN cord-335975-m6lkrehi 1566 24 improved improved JJ cord-335975-m6lkrehi 1566 25 outcomes outcome NNS cord-335975-m6lkrehi 1566 26 . . . cord-335975-m6lkrehi 1567 1 Our -PRON- PRP$ cord-335975-m6lkrehi 1567 2 data datum NNS cord-335975-m6lkrehi 1567 3 suggest suggest VBP cord-335975-m6lkrehi 1567 4 that that IN cord-335975-m6lkrehi 1567 5 , , , cord-335975-m6lkrehi 1567 6 more more JJR cord-335975-m6lkrehi 1567 7 than than IN cord-335975-m6lkrehi 1567 8 the the DT cord-335975-m6lkrehi 1567 9 protocol protocol NN cord-335975-m6lkrehi 1567 10 by by IN cord-335975-m6lkrehi 1567 11 itself -PRON- PRP cord-335975-m6lkrehi 1567 12 , , , cord-335975-m6lkrehi 1567 13 beneficial beneficial JJ cord-335975-m6lkrehi 1567 14 effects effect NNS cord-335975-m6lkrehi 1567 15 reported report VBN cord-335975-m6lkrehi 1567 16 after after IN cord-335975-m6lkrehi 1567 17 the the DT cord-335975-m6lkrehi 1567 18 implementation implementation NN cord-335975-m6lkrehi 1567 19 of of IN cord-335975-m6lkrehi 1567 20 a a DT cord-335975-m6lkrehi 1567 21 sedation sedation NN cord-335975-m6lkrehi 1567 22 protocol protocol NN cord-335975-m6lkrehi 1567 23 may may MD cord-335975-m6lkrehi 1567 24 be be VB cord-335975-m6lkrehi 1567 25 ascribed ascribe VBN cord-335975-m6lkrehi 1567 26 to to IN cord-335975-m6lkrehi 1567 27 increased increase VBN cord-335975-m6lkrehi 1567 28 awareness awareness NN cord-335975-m6lkrehi 1567 29 of of IN cord-335975-m6lkrehi 1567 30 the the DT cord-335975-m6lkrehi 1567 31 care care NN cord-335975-m6lkrehi 1567 32 givers giver NNS cord-335975-m6lkrehi 1567 33 and and CC cord-335975-m6lkrehi 1567 34 thus thus RB cord-335975-m6lkrehi 1567 35 better well JJR cord-335975-m6lkrehi 1567 36 management management NN cord-335975-m6lkrehi 1567 37 of of IN cord-335975-m6lkrehi 1567 38 sedation sedation NN cord-335975-m6lkrehi 1567 39 . . . cord-335975-m6lkrehi 1568 1 Introduction introduction NN cord-335975-m6lkrehi 1568 2 : : : cord-335975-m6lkrehi 1569 1 Workload workload NN cord-335975-m6lkrehi 1569 2 affects affect VBZ cord-335975-m6lkrehi 1569 3 the the DT cord-335975-m6lkrehi 1569 4 quality quality NN cord-335975-m6lkrehi 1569 5 of of IN cord-335975-m6lkrehi 1569 6 care care NN cord-335975-m6lkrehi 1569 7 and and CC cord-335975-m6lkrehi 1569 8 the the DT cord-335975-m6lkrehi 1569 9 prognosis prognosis NN cord-335975-m6lkrehi 1569 10 of of IN cord-335975-m6lkrehi 1569 11 critically critically RB cord-335975-m6lkrehi 1569 12 ills ill NNS cord-335975-m6lkrehi 1569 13 patients patient NNS cord-335975-m6lkrehi 1569 14 . . . cord-335975-m6lkrehi 1570 1 Measuring measure VBG cord-335975-m6lkrehi 1570 2 workload workload NN cord-335975-m6lkrehi 1570 3 in in IN cord-335975-m6lkrehi 1570 4 intensive intensive JJ cord-335975-m6lkrehi 1570 5 care care NN cord-335975-m6lkrehi 1570 6 units unit NNS cord-335975-m6lkrehi 1570 7 ( ( -LRB- cord-335975-m6lkrehi 1570 8 ICU ICU NNP cord-335975-m6lkrehi 1570 9 ) ) -RRB- cord-335975-m6lkrehi 1570 10 has have VBZ cord-335975-m6lkrehi 1570 11 thus thus RB cord-335975-m6lkrehi 1570 12 become become VBN cord-335975-m6lkrehi 1570 13 essential essential JJ cord-335975-m6lkrehi 1570 14 for for IN cord-335975-m6lkrehi 1570 15 allowing allow VBG cord-335975-m6lkrehi 1570 16 a a DT cord-335975-m6lkrehi 1570 17 better well JJR cord-335975-m6lkrehi 1570 18 matching matching NN cord-335975-m6lkrehi 1570 19 between between IN cord-335975-m6lkrehi 1570 20 the the DT cord-335975-m6lkrehi 1570 21 activities activity NNS cord-335975-m6lkrehi 1570 22 required require VBN cord-335975-m6lkrehi 1570 23 and and CC cord-335975-m6lkrehi 1570 24 the the DT cord-335975-m6lkrehi 1570 25 management management NN cord-335975-m6lkrehi 1570 26 of of IN cord-335975-m6lkrehi 1570 27 resources resource NNS cord-335975-m6lkrehi 1570 28 . . . cord-335975-m6lkrehi 1571 1 In in IN cord-335975-m6lkrehi 1571 2 March March NNP cord-335975-m6lkrehi 1571 3 2016 2016 CD cord-335975-m6lkrehi 1571 4 , , , cord-335975-m6lkrehi 1571 5 the the DT cord-335975-m6lkrehi 1571 6 medical medical JJ cord-335975-m6lkrehi 1571 7 ICU ICU NNP cord-335975-m6lkrehi 1571 8 of of IN cord-335975-m6lkrehi 1571 9 the the DT cord-335975-m6lkrehi 1571 10 university university NN cord-335975-m6lkrehi 1571 11 hospital hospital NN cord-335975-m6lkrehi 1571 12 of of IN cord-335975-m6lkrehi 1571 13 Monastir Monastir NNP cord-335975-m6lkrehi 1571 14 ( ( -LRB- cord-335975-m6lkrehi 1571 15 Tunisia Tunisia NNP cord-335975-m6lkrehi 1571 16 ) ) -RRB- cord-335975-m6lkrehi 1571 17 moved move VBD cord-335975-m6lkrehi 1571 18 into into IN cord-335975-m6lkrehi 1571 19 new new JJ cord-335975-m6lkrehi 1571 20 buildings building NNS cord-335975-m6lkrehi 1571 21 ( ( -LRB- cord-335975-m6lkrehi 1571 22 more more JJR cord-335975-m6lkrehi 1571 23 space space NN cord-335975-m6lkrehi 1571 24 and and CC cord-335975-m6lkrehi 1571 25 beds bed NNS cord-335975-m6lkrehi 1571 26 , , , cord-335975-m6lkrehi 1571 27 computerbased computerbased JJ cord-335975-m6lkrehi 1571 28 prescriptions prescription NNS cord-335975-m6lkrehi 1571 29 and and CC cord-335975-m6lkrehi 1571 30 monitoring monitoring NN cord-335975-m6lkrehi 1571 31 , , , cord-335975-m6lkrehi 1571 32 etc etc FW cord-335975-m6lkrehi 1571 33 . . . cord-335975-m6lkrehi 1571 34 ) ) -RRB- cord-335975-m6lkrehi 1571 35 . . . cord-335975-m6lkrehi 1572 1 The the DT cord-335975-m6lkrehi 1572 2 aim aim NN cord-335975-m6lkrehi 1572 3 of of IN cord-335975-m6lkrehi 1572 4 the the DT cord-335975-m6lkrehi 1572 5 present present JJ cord-335975-m6lkrehi 1572 6 study study NN cord-335975-m6lkrehi 1572 7 is be VBZ cord-335975-m6lkrehi 1572 8 to to TO cord-335975-m6lkrehi 1572 9 compare compare VB cord-335975-m6lkrehi 1572 10 the the DT cord-335975-m6lkrehi 1572 11 level level NN cord-335975-m6lkrehi 1572 12 of of IN cord-335975-m6lkrehi 1572 13 workload workload NN cord-335975-m6lkrehi 1572 14 before before IN cord-335975-m6lkrehi 1572 15 and and CC cord-335975-m6lkrehi 1572 16 after after IN cord-335975-m6lkrehi 1572 17 the the DT cord-335975-m6lkrehi 1572 18 change change NN cord-335975-m6lkrehi 1572 19 of of IN cord-335975-m6lkrehi 1572 20 the the DT cord-335975-m6lkrehi 1572 21 ICU ICU NNP cord-335975-m6lkrehi 1572 22 buildings building NNS cord-335975-m6lkrehi 1572 23 . . . cord-335975-m6lkrehi 1573 1 Patients patient NNS cord-335975-m6lkrehi 1573 2 and and CC cord-335975-m6lkrehi 1573 3 methods method NNS cord-335975-m6lkrehi 1573 4 : : : cord-335975-m6lkrehi 1573 5 During during IN cord-335975-m6lkrehi 1573 6 the the DT cord-335975-m6lkrehi 1573 7 two two CD cord-335975-m6lkrehi 1573 8 study study NN cord-335975-m6lkrehi 1573 9 periods period NNS cord-335975-m6lkrehi 1573 10 ( ( -LRB- cord-335975-m6lkrehi 1573 11 period period NN cord-335975-m6lkrehi 1573 12 1-July 1-july CD cord-335975-m6lkrehi 1573 13 - - : cord-335975-m6lkrehi 1573 14 September September NNP cord-335975-m6lkrehi 1573 15 2015 2015 CD cord-335975-m6lkrehi 1573 16 and and CC cord-335975-m6lkrehi 1573 17 period period NN cord-335975-m6lkrehi 1573 18 2-July 2-july CD cord-335975-m6lkrehi 1573 19 - - HYPH cord-335975-m6lkrehi 1573 20 September September NNP cord-335975-m6lkrehi 1573 21 2017 2017 CD cord-335975-m6lkrehi 1573 22 ) ) -RRB- cord-335975-m6lkrehi 1574 1 adult adult NN cord-335975-m6lkrehi 1574 2 patients patient NNS cord-335975-m6lkrehi 1574 3 consecutively consecutively RB cord-335975-m6lkrehi 1574 4 admitted admit VBN cord-335975-m6lkrehi 1574 5 , , , cord-335975-m6lkrehi 1574 6 for for IN cord-335975-m6lkrehi 1574 7 more more JJR cord-335975-m6lkrehi 1574 8 than than IN cord-335975-m6lkrehi 1574 9 24 24 CD cord-335975-m6lkrehi 1574 10 h h NN cord-335975-m6lkrehi 1574 11 , , , cord-335975-m6lkrehi 1574 12 in in IN cord-335975-m6lkrehi 1574 13 the the DT cord-335975-m6lkrehi 1574 14 medical medical JJ cord-335975-m6lkrehi 1574 15 ICU ICU NNP cord-335975-m6lkrehi 1574 16 for for IN cord-335975-m6lkrehi 1574 17 ARF arf NN cord-335975-m6lkrehi 1574 18 and and CC cord-335975-m6lkrehi 1574 19 or or CC cord-335975-m6lkrehi 1574 20 sepsis sepsis NN cord-335975-m6lkrehi 1574 21 were be VBD cord-335975-m6lkrehi 1574 22 included include VBN cord-335975-m6lkrehi 1574 23 in in IN cord-335975-m6lkrehi 1574 24 the the DT cord-335975-m6lkrehi 1574 25 analysis analysis NN cord-335975-m6lkrehi 1574 26 . . . cord-335975-m6lkrehi 1575 1 Data datum NNS cord-335975-m6lkrehi 1575 2 collected collect VBN cord-335975-m6lkrehi 1575 3 were be VBD cord-335975-m6lkrehi 1575 4 the the DT cord-335975-m6lkrehi 1575 5 demographic demographic JJ cord-335975-m6lkrehi 1575 6 characteristics characteristic NNS cord-335975-m6lkrehi 1575 7 ( ( -LRB- cord-335975-m6lkrehi 1575 8 age age NN cord-335975-m6lkrehi 1575 9 , , , cord-335975-m6lkrehi 1575 10 sex sex NN cord-335975-m6lkrehi 1575 11 , , , cord-335975-m6lkrehi 1575 12 Body Body NNP cord-335975-m6lkrehi 1575 13 Mass Mass NNP cord-335975-m6lkrehi 1575 14 Index Index NNP cord-335975-m6lkrehi 1575 15 ( ( -LRB- cord-335975-m6lkrehi 1575 16 BMI BMI NNP cord-335975-m6lkrehi 1575 17 ) ) -RRB- cord-335975-m6lkrehi 1575 18 , , , cord-335975-m6lkrehi 1575 19 comorbidities comorbiditie NNS cord-335975-m6lkrehi 1575 20 , , , cord-335975-m6lkrehi 1575 21 Simplified Simplified NNP cord-335975-m6lkrehi 1575 22 Acute Acute NNP cord-335975-m6lkrehi 1575 23 Physiology Physiology NNP cord-335975-m6lkrehi 1575 24 Score score NN cord-335975-m6lkrehi 1575 25 ( ( -LRB- cord-335975-m6lkrehi 1575 26 SAPS SAPS NNP cord-335975-m6lkrehi 1575 27 ) ) -RRB- cord-335975-m6lkrehi 1575 28 III III NNP cord-335975-m6lkrehi 1575 29 ) ) -RRB- cord-335975-m6lkrehi 1575 30 , , , cord-335975-m6lkrehi 1575 31 the the DT cord-335975-m6lkrehi 1575 32 nursing nursing NN cord-335975-m6lkrehi 1575 33 workload workload NN cord-335975-m6lkrehi 1575 34 measured measure VBN cord-335975-m6lkrehi 1575 35 using use VBG cord-335975-m6lkrehi 1575 36 the the DT cord-335975-m6lkrehi 1575 37 Therapeutic Therapeutic NNP cord-335975-m6lkrehi 1575 38 Intervention Intervention NNP cord-335975-m6lkrehi 1575 39 Scoring Scoring NNP cord-335975-m6lkrehi 1575 40 System System NNP cord-335975-m6lkrehi 1575 41 ( ( -LRB- cord-335975-m6lkrehi 1575 42 TISS-28 tiss-28 CD cord-335975-m6lkrehi 1575 43 ) ) -RRB- cord-335975-m6lkrehi 1575 44 and and CC cord-335975-m6lkrehi 1575 45 hospital hospital NN cord-335975-m6lkrehi 1575 46 survival survival NN cord-335975-m6lkrehi 1575 47 . . . cord-335975-m6lkrehi 1576 1 Results result NNS cord-335975-m6lkrehi 1576 2 : : : cord-335975-m6lkrehi 1577 1 Thirty thirty CD cord-335975-m6lkrehi 1577 2 - - HYPH cord-335975-m6lkrehi 1577 3 six six CD cord-335975-m6lkrehi 1577 4 patients patient NNS cord-335975-m6lkrehi 1577 5 ( ( -LRB- cord-335975-m6lkrehi 1577 6 22 22 CD cord-335975-m6lkrehi 1577 7 male male NN cord-335975-m6lkrehi 1577 8 ) ) -RRB- cord-335975-m6lkrehi 1577 9 were be VBD cord-335975-m6lkrehi 1577 10 included include VBN cord-335975-m6lkrehi 1577 11 in in IN cord-335975-m6lkrehi 1577 12 the the DT cord-335975-m6lkrehi 1577 13 study study NN cord-335975-m6lkrehi 1577 14 ( ( -LRB- cord-335975-m6lkrehi 1577 15 14 14 CD cord-335975-m6lkrehi 1577 16 during during IN cord-335975-m6lkrehi 1577 17 Period Period NNP cord-335975-m6lkrehi 1577 18 1 1 CD cord-335975-m6lkrehi 1577 19 and and CC cord-335975-m6lkrehi 1577 20 22 22 CD cord-335975-m6lkrehi 1577 21 during during IN cord-335975-m6lkrehi 1577 22 the the DT cord-335975-m6lkrehi 1577 23 second second JJ cord-335975-m6lkrehi 1577 24 period period NN cord-335975-m6lkrehi 1577 25 ) ) -RRB- cord-335975-m6lkrehi 1577 26 . . . cord-335975-m6lkrehi 1578 1 The the DT cord-335975-m6lkrehi 1578 2 medians median NNS cord-335975-m6lkrehi 1578 3 of of IN cord-335975-m6lkrehi 1578 4 age age NN cord-335975-m6lkrehi 1578 5 , , , cord-335975-m6lkrehi 1578 6 SAPS SAPS NNP cord-335975-m6lkrehi 1578 7 III III NNP cord-335975-m6lkrehi 1578 8 and and CC cord-335975-m6lkrehi 1578 9 BMI BMI NNP cord-335975-m6lkrehi 1578 10 were be VBD cord-335975-m6lkrehi 1578 11 respectively respectively RB cord-335975-m6lkrehi 1578 12 65 65 CD cord-335975-m6lkrehi 1578 13 ( ( -LRB- cord-335975-m6lkrehi 1578 14 IQR IQR NNP cord-335975-m6lkrehi 1578 15 = = SYM cord-335975-m6lkrehi 1578 16 21 21 CD cord-335975-m6lkrehi 1578 17 ) ) -RRB- cord-335975-m6lkrehi 1578 18 years year NNS cord-335975-m6lkrehi 1578 19 , , , cord-335975-m6lkrehi 1578 20 46 46 CD cord-335975-m6lkrehi 1578 21 ( ( -LRB- cord-335975-m6lkrehi 1578 22 IQR IQR NNP cord-335975-m6lkrehi 1578 23 = = SYM cord-335975-m6lkrehi 1578 24 12 12 CD cord-335975-m6lkrehi 1578 25 ) ) -RRB- cord-335975-m6lkrehi 1578 26 and and CC cord-335975-m6lkrehi 1578 27 27.7 27.7 CD cord-335975-m6lkrehi 1578 28 ( ( -LRB- cord-335975-m6lkrehi 1578 29 IQR iqr NN cord-335975-m6lkrehi 1578 30 = = SYM cord-335975-m6lkrehi 1578 31 9.4 9.4 CD cord-335975-m6lkrehi 1578 32 ) ) -RRB- cord-335975-m6lkrehi 1578 33 . . . cord-335975-m6lkrehi 1579 1 The the DT cord-335975-m6lkrehi 1579 2 main main JJ cord-335975-m6lkrehi 1579 3 comorbidities comorbiditie NNS cord-335975-m6lkrehi 1579 4 were be VBD cord-335975-m6lkrehi 1579 5 hypertension hypertension NN cord-335975-m6lkrehi 1579 6 , , , cord-335975-m6lkrehi 1579 7 COPD COPD NNP cord-335975-m6lkrehi 1579 8 and and CC cord-335975-m6lkrehi 1579 9 neurological neurological JJ cord-335975-m6lkrehi 1579 10 disease disease NN cord-335975-m6lkrehi 1579 11 respectively respectively RB cord-335975-m6lkrehi 1579 12 in in IN cord-335975-m6lkrehi 1579 13 36 36 CD cord-335975-m6lkrehi 1579 14 , , , cord-335975-m6lkrehi 1579 15 25 25 CD cord-335975-m6lkrehi 1579 16 and and CC cord-335975-m6lkrehi 1579 17 20 20 CD cord-335975-m6lkrehi 1579 18 % % NN cord-335975-m6lkrehi 1579 19 . . . cord-335975-m6lkrehi 1580 1 The the DT cord-335975-m6lkrehi 1580 2 demographic demographic JJ cord-335975-m6lkrehi 1580 3 characteristics characteristic NNS cord-335975-m6lkrehi 1580 4 were be VBD cord-335975-m6lkrehi 1580 5 similar similar JJ cord-335975-m6lkrehi 1580 6 during during IN cord-335975-m6lkrehi 1580 7 the the DT cord-335975-m6lkrehi 1580 8 two two CD cord-335975-m6lkrehi 1580 9 periods period NNS cord-335975-m6lkrehi 1580 10 . . . cord-335975-m6lkrehi 1581 1 Nurse nurse NN cord-335975-m6lkrehi 1581 2 workload workload NN cord-335975-m6lkrehi 1581 3 was be VBD cord-335975-m6lkrehi 1581 4 characterized characterize VBN cord-335975-m6lkrehi 1581 5 by by IN cord-335975-m6lkrehi 1581 6 m m NNP cord-335975-m6lkrehi 1581 7 TISS-28 TISS-28 NNP cord-335975-m6lkrehi 1581 8 = = SYM cord-335975-m6lkrehi 1581 9 18 18 CD cord-335975-m6lkrehi 1581 10 ( ( -LRB- cord-335975-m6lkrehi 1581 11 IQR IQR NNP cord-335975-m6lkrehi 1581 12 = = SYM cord-335975-m6lkrehi 1581 13 7 7 CD cord-335975-m6lkrehi 1581 14 ) ) -RRB- cord-335975-m6lkrehi 1581 15 and and CC cord-335975-m6lkrehi 1581 16 Time Time NNP cord-335975-m6lkrehi 1581 17 of of IN cord-335975-m6lkrehi 1581 18 nurse nurse NN cord-335975-m6lkrehi 1581 19 's 's POS cord-335975-m6lkrehi 1581 20 care care NN cord-335975-m6lkrehi 1581 21 of of IN cord-335975-m6lkrehi 1581 22 190 190 CD cord-335975-m6lkrehi 1581 23 min min NN cord-335975-m6lkrehi 1581 24 ( ( -LRB- cord-335975-m6lkrehi 1581 25 IQR iqr NN cord-335975-m6lkrehi 1581 26 = = SYM cord-335975-m6lkrehi 1581 27 74 74 CD cord-335975-m6lkrehi 1581 28 ) ) -RRB- cord-335975-m6lkrehi 1581 29 . . . cord-335975-m6lkrehi 1582 1 These these DT cord-335975-m6lkrehi 1582 2 two two CD cord-335975-m6lkrehi 1582 3 workload workload NN cord-335975-m6lkrehi 1582 4 indicators indicator NNS cord-335975-m6lkrehi 1582 5 were be VBD cord-335975-m6lkrehi 1582 6 significantly significantly RB cord-335975-m6lkrehi 1582 7 higher high JJR cord-335975-m6lkrehi 1582 8 during during IN cord-335975-m6lkrehi 1582 9 the the DT cord-335975-m6lkrehi 1582 10 second second JJ cord-335975-m6lkrehi 1582 11 period period NN cord-335975-m6lkrehi 1582 12 ( ( -LRB- cord-335975-m6lkrehi 1582 13 Table table NN cord-335975-m6lkrehi 1582 14 1 1 CD cord-335975-m6lkrehi 1582 15 ) ) -RRB- cord-335975-m6lkrehi 1582 16 . . . cord-335975-m6lkrehi 1583 1 During during IN cord-335975-m6lkrehi 1583 2 the the DT cord-335975-m6lkrehi 1583 3 second second JJ cord-335975-m6lkrehi 1583 4 period period NN cord-335975-m6lkrehi 1583 5 , , , cord-335975-m6lkrehi 1583 6 " " '' cord-335975-m6lkrehi 1583 7 standard standard JJ cord-335975-m6lkrehi 1583 8 monitoring monitoring NN cord-335975-m6lkrehi 1583 9 " " '' cord-335975-m6lkrehi 1583 10 and and CC cord-335975-m6lkrehi 1583 11 " " `` cord-335975-m6lkrehi 1583 12 frequent frequent JJ cord-335975-m6lkrehi 1583 13 dressing dressing NN cord-335975-m6lkrehi 1583 14 changes change NNS cord-335975-m6lkrehi 1583 15 " " '' cord-335975-m6lkrehi 1583 16 ( ( -LRB- cord-335975-m6lkrehi 1583 17 > > NFP cord-335975-m6lkrehi 1583 18 3 3 CD cord-335975-m6lkrehi 1583 19 time time NN cord-335975-m6lkrehi 1583 20 day day NN cord-335975-m6lkrehi 1583 21 ) ) -RRB- cord-335975-m6lkrehi 1583 22 were be VBD cord-335975-m6lkrehi 1583 23 the the DT cord-335975-m6lkrehi 1583 24 activities activity NNS cord-335975-m6lkrehi 1583 25 with with IN cord-335975-m6lkrehi 1583 26 significant significant JJ cord-335975-m6lkrehi 1583 27 increase increase NN cord-335975-m6lkrehi 1583 28 from from IN cord-335975-m6lkrehi 1583 29 , , , cord-335975-m6lkrehi 1583 30 respectively respectively RB cord-335975-m6lkrehi 1583 31 81 81 CD cord-335975-m6lkrehi 1583 32 to to TO cord-335975-m6lkrehi 1583 33 91 91 CD cord-335975-m6lkrehi 1583 34 % % NN cord-335975-m6lkrehi 1583 35 ( ( -LRB- cord-335975-m6lkrehi 1583 36 p p NN cord-335975-m6lkrehi 1583 37 < < XX cord-335975-m6lkrehi 1583 38 0.0001 0.0001 CD cord-335975-m6lkrehi 1583 39 ) ) -RRB- cord-335975-m6lkrehi 1583 40 and and CC cord-335975-m6lkrehi 1583 41 from from IN cord-335975-m6lkrehi 1583 42 41 41 CD cord-335975-m6lkrehi 1583 43 to to TO cord-335975-m6lkrehi 1583 44 88 88 CD cord-335975-m6lkrehi 1583 45 % % NN cord-335975-m6lkrehi 1583 46 ( ( -LRB- cord-335975-m6lkrehi 1583 47 p p NN cord-335975-m6lkrehi 1583 48 < < XX cord-335975-m6lkrehi 1583 49 0.0001 0.0001 CD cord-335975-m6lkrehi 1583 50 ) ) -RRB- cord-335975-m6lkrehi 1583 51 . . . cord-335975-m6lkrehi 1584 1 The the DT cord-335975-m6lkrehi 1584 2 relocation relocation NN cord-335975-m6lkrehi 1584 3 of of IN cord-335975-m6lkrehi 1584 4 our -PRON- PRP$ cord-335975-m6lkrehi 1584 5 ICU ICU NNP cord-335975-m6lkrehi 1584 6 in in IN cord-335975-m6lkrehi 1584 7 in in IN cord-335975-m6lkrehi 1584 8 new new JJ cord-335975-m6lkrehi 1584 9 buildings building NNS cord-335975-m6lkrehi 1584 10 was be VBD cord-335975-m6lkrehi 1584 11 associated associate VBN cord-335975-m6lkrehi 1584 12 with with IN cord-335975-m6lkrehi 1584 13 a a DT cord-335975-m6lkrehi 1584 14 significant significant JJ cord-335975-m6lkrehi 1584 15 increase increase NN cord-335975-m6lkrehi 1584 16 of of IN cord-335975-m6lkrehi 1584 17 the the DT cord-335975-m6lkrehi 1584 18 nurse nurse NN cord-335975-m6lkrehi 1584 19 workload workload NN cord-335975-m6lkrehi 1584 20 with with IN cord-335975-m6lkrehi 1584 21 regard regard NN cord-335975-m6lkrehi 1584 22 to to IN cord-335975-m6lkrehi 1584 23 patients patient NNS cord-335975-m6lkrehi 1584 24 with with IN cord-335975-m6lkrehi 1584 25 ARF arf NN cord-335975-m6lkrehi 1584 26 and and CC cord-335975-m6lkrehi 1584 27 or or CC cord-335975-m6lkrehi 1584 28 sepsis sepsis NN cord-335975-m6lkrehi 1584 29 . . . cord-335975-m6lkrehi 1584 30 . . . cord-335975-m6lkrehi 1585 1 Bland Bland NNP cord-335975-m6lkrehi 1585 2 - - HYPH cord-335975-m6lkrehi 1585 3 Altman Altman NNP cord-335975-m6lkrehi 1585 4 analysis analysis NN cord-335975-m6lkrehi 1585 5 showed show VBD cord-335975-m6lkrehi 1585 6 excellent excellent JJ cord-335975-m6lkrehi 1585 7 accuracy accuracy NN cord-335975-m6lkrehi 1585 8 and and CC cord-335975-m6lkrehi 1585 9 precision precision NN cord-335975-m6lkrehi 1585 10 between between IN cord-335975-m6lkrehi 1585 11 recorded record VBN cord-335975-m6lkrehi 1585 12 and and CC cord-335975-m6lkrehi 1585 13 collected collect VBN cord-335975-m6lkrehi 1585 14 data datum NNS cord-335975-m6lkrehi 1585 15 for for IN cord-335975-m6lkrehi 1585 16 all all DT cord-335975-m6lkrehi 1585 17 tested test VBN cord-335975-m6lkrehi 1585 18 variables variable NNS cord-335975-m6lkrehi 1585 19 within within IN cord-335975-m6lkrehi 1585 20 clinically clinically RB cord-335975-m6lkrehi 1585 21 significant significant JJ cord-335975-m6lkrehi 1585 22 pre pre JJ cord-335975-m6lkrehi 1585 23 - - JJ cord-335975-m6lkrehi 1585 24 defined defined JJ cord-335975-m6lkrehi 1585 25 limits limit NNS cord-335975-m6lkrehi 1585 26 of of IN cord-335975-m6lkrehi 1585 27 agreement agreement NN cord-335975-m6lkrehi 1585 28 . . . cord-335975-m6lkrehi 1586 1 However however RB cord-335975-m6lkrehi 1586 2 , , , cord-335975-m6lkrehi 1586 3 82 82 CD cord-335975-m6lkrehi 1586 4 ( ( -LRB- cord-335975-m6lkrehi 1586 5 2.5 2.5 CD cord-335975-m6lkrehi 1586 6 % % NN cord-335975-m6lkrehi 1586 7 ) ) -RRB- cord-335975-m6lkrehi 1586 8 data datum NNS cord-335975-m6lkrehi 1586 9 were be VBD cord-335975-m6lkrehi 1586 10 missing miss VBG cord-335975-m6lkrehi 1586 11 and and CC cord-335975-m6lkrehi 1586 12 a a DT cord-335975-m6lkrehi 1586 13 delay delay NN cord-335975-m6lkrehi 1586 14 was be VBD cord-335975-m6lkrehi 1586 15 observed observe VBN cord-335975-m6lkrehi 1586 16 between between IN cord-335975-m6lkrehi 1586 17 videotaped videotape VBN cord-335975-m6lkrehi 1586 18 and and CC cord-335975-m6lkrehi 1586 19 collected collect VBN cord-335975-m6lkrehi 1586 20 times time NNS cord-335975-m6lkrehi 1586 21 . . . cord-335975-m6lkrehi 1587 1 This this DT cord-335975-m6lkrehi 1587 2 delay delay NN cord-335975-m6lkrehi 1587 3 was be VBD cord-335975-m6lkrehi 1587 4 less less JJR cord-335975-m6lkrehi 1587 5 than than IN cord-335975-m6lkrehi 1587 6 28 28 CD cord-335975-m6lkrehi 1587 7 s s NNS cord-335975-m6lkrehi 1587 8 and and CC cord-335975-m6lkrehi 1587 9 remained remain VBD cord-335975-m6lkrehi 1587 10 stable stable JJ cord-335975-m6lkrehi 1587 11 through through IN cord-335975-m6lkrehi 1587 12 all all DT cord-335975-m6lkrehi 1587 13 data datum NNS cord-335975-m6lkrehi 1587 14 for for IN cord-335975-m6lkrehi 1587 15 each each DT cord-335975-m6lkrehi 1587 16 patient patient NN cord-335975-m6lkrehi 1587 17 . . . cord-335975-m6lkrehi 1588 1 We -PRON- PRP cord-335975-m6lkrehi 1588 2 identified identify VBD cord-335975-m6lkrehi 1588 3 that that IN cord-335975-m6lkrehi 1588 4 the the DT cord-335975-m6lkrehi 1588 5 missing miss VBG cord-335975-m6lkrehi 1588 6 data datum NNS cord-335975-m6lkrehi 1588 7 were be VBD cord-335975-m6lkrehi 1588 8 due due JJ cord-335975-m6lkrehi 1588 9 to to IN cord-335975-m6lkrehi 1588 10 a a DT cord-335975-m6lkrehi 1588 11 limit limit NN cord-335975-m6lkrehi 1588 12 in in IN cord-335975-m6lkrehi 1588 13 the the DT cord-335975-m6lkrehi 1588 14 number number NN cord-335975-m6lkrehi 1588 15 of of IN cord-335975-m6lkrehi 1588 16 data datum NNS cord-335975-m6lkrehi 1588 17 being be VBG cord-335975-m6lkrehi 1588 18 processed process VBN cord-335975-m6lkrehi 1588 19 in in IN cord-335975-m6lkrehi 1588 20 the the DT cord-335975-m6lkrehi 1588 21 database database NN cord-335975-m6lkrehi 1588 22 at at IN cord-335975-m6lkrehi 1588 23 the the DT cord-335975-m6lkrehi 1588 24 same same JJ cord-335975-m6lkrehi 1588 25 time time NN cord-335975-m6lkrehi 1588 26 and and CC cord-335975-m6lkrehi 1588 27 the the DT cord-335975-m6lkrehi 1588 28 delay delay NN cord-335975-m6lkrehi 1588 29 between between IN cord-335975-m6lkrehi 1588 30 data data NN cord-335975-m6lkrehi 1588 31 presentation presentation NN cord-335975-m6lkrehi 1588 32 and and CC cord-335975-m6lkrehi 1588 33 data data NN cord-335975-m6lkrehi 1588 34 collection collection NN cord-335975-m6lkrehi 1588 35 in in IN cord-335975-m6lkrehi 1588 36 the the DT cord-335975-m6lkrehi 1588 37 database database NN cord-335975-m6lkrehi 1588 38 was be VBD cord-335975-m6lkrehi 1588 39 due due JJ cord-335975-m6lkrehi 1588 40 to to IN cord-335975-m6lkrehi 1588 41 different different JJ cord-335975-m6lkrehi 1588 42 server server NN cord-335975-m6lkrehi 1588 43 time time NN cord-335975-m6lkrehi 1588 44 settings setting NNS cord-335975-m6lkrehi 1588 45 . . . cord-335975-m6lkrehi 1589 1 Both both DT cord-335975-m6lkrehi 1589 2 technical technical JJ cord-335975-m6lkrehi 1589 3 issues issue NNS cord-335975-m6lkrehi 1589 4 were be VBD cord-335975-m6lkrehi 1589 5 corrected correct VBN cord-335975-m6lkrehi 1589 6 . . . cord-335975-m6lkrehi 1590 1 Conclusion conclusion NN cord-335975-m6lkrehi 1590 2 : : : cord-335975-m6lkrehi 1591 1 Our -PRON- PRP$ cord-335975-m6lkrehi 1591 2 study study NN cord-335975-m6lkrehi 1591 3 identified identify VBD cord-335975-m6lkrehi 1591 4 two two CD cord-335975-m6lkrehi 1591 5 issues issue NNS cord-335975-m6lkrehi 1591 6 in in IN cord-335975-m6lkrehi 1591 7 the the DT cord-335975-m6lkrehi 1591 8 data data NN cord-335975-m6lkrehi 1591 9 collection collection NN cord-335975-m6lkrehi 1591 10 process process NN cord-335975-m6lkrehi 1591 11 that that WDT cord-335975-m6lkrehi 1591 12 slightly slightly RB cord-335975-m6lkrehi 1591 13 limited limit VBD cord-335975-m6lkrehi 1591 14 the the DT cord-335975-m6lkrehi 1591 15 accuracy accuracy NN cord-335975-m6lkrehi 1591 16 of of IN cord-335975-m6lkrehi 1591 17 our -PRON- PRP$ cord-335975-m6lkrehi 1591 18 high high JJ cord-335975-m6lkrehi 1591 19 resolution resolution NN cord-335975-m6lkrehi 1591 20 electronic electronic JJ cord-335975-m6lkrehi 1591 21 database database NN cord-335975-m6lkrehi 1591 22 . . . cord-335975-m6lkrehi 1592 1 We -PRON- PRP cord-335975-m6lkrehi 1592 2 recommend recommend VBP cord-335975-m6lkrehi 1592 3 the the DT cord-335975-m6lkrehi 1592 4 performance performance NN cord-335975-m6lkrehi 1592 5 of of IN cord-335975-m6lkrehi 1592 6 such such JJ cord-335975-m6lkrehi 1592 7 validation validation NN cord-335975-m6lkrehi 1592 8 study study NN cord-335975-m6lkrehi 1592 9 before before IN cord-335975-m6lkrehi 1592 10 using use VBG cord-335975-m6lkrehi 1592 11 a a DT cord-335975-m6lkrehi 1592 12 high high JJ cord-335975-m6lkrehi 1592 13 resolution resolution NN cord-335975-m6lkrehi 1592 14 database database NN cord-335975-m6lkrehi 1592 15 for for IN cord-335975-m6lkrehi 1592 16 clinical clinical JJ cord-335975-m6lkrehi 1592 17 or or CC cord-335975-m6lkrehi 1592 18 research research NN cord-335975-m6lkrehi 1592 19 purposes purpose NNS cord-335975-m6lkrehi 1592 20 . . . cord-335975-m6lkrehi 1593 1 Introduction introduction NN cord-335975-m6lkrehi 1593 2 : : : cord-335975-m6lkrehi 1594 1 Fluid fluid JJ cord-335975-m6lkrehi 1594 2 overload overload NN cord-335975-m6lkrehi 1594 3 , , , cord-335975-m6lkrehi 1594 4 and and CC cord-335975-m6lkrehi 1594 5 also also RB cord-335975-m6lkrehi 1594 6 its -PRON- PRP$ cord-335975-m6lkrehi 1594 7 variations variation NNS cord-335975-m6lkrehi 1594 8 , , , cord-335975-m6lkrehi 1594 9 is be VBZ cord-335975-m6lkrehi 1594 10 known know VBN cord-335975-m6lkrehi 1594 11 to to TO cord-335975-m6lkrehi 1594 12 jeopardize jeopardize VB cord-335975-m6lkrehi 1594 13 the the DT cord-335975-m6lkrehi 1594 14 outcome outcome NN cord-335975-m6lkrehi 1594 15 of of IN cord-335975-m6lkrehi 1594 16 ICU ICU NNP cord-335975-m6lkrehi 1594 17 patients patient NNS cord-335975-m6lkrehi 1594 18 . . . cord-335975-m6lkrehi 1595 1 However however RB cord-335975-m6lkrehi 1595 2 , , , cord-335975-m6lkrehi 1595 3 fluid fluid JJ cord-335975-m6lkrehi 1595 4 balance balance NN cord-335975-m6lkrehi 1595 5 remains remain VBZ cord-335975-m6lkrehi 1595 6 difficult difficult JJ cord-335975-m6lkrehi 1595 7 to to TO cord-335975-m6lkrehi 1595 8 assess assess VB cord-335975-m6lkrehi 1595 9 accurately accurately RB cord-335975-m6lkrehi 1595 10 . . . cord-335975-m6lkrehi 1596 1 In in IN cord-335975-m6lkrehi 1596 2 that that DT cord-335975-m6lkrehi 1596 3 context context NN cord-335975-m6lkrehi 1596 4 , , , cord-335975-m6lkrehi 1596 5 our -PRON- PRP$ cord-335975-m6lkrehi 1596 6 study study NN cord-335975-m6lkrehi 1596 7 aims aim VBZ cord-335975-m6lkrehi 1596 8 to to TO cord-335975-m6lkrehi 1596 9 assess assess VB cord-335975-m6lkrehi 1596 10 the the DT cord-335975-m6lkrehi 1596 11 prognostic prognostic JJ cord-335975-m6lkrehi 1596 12 value value NN cord-335975-m6lkrehi 1596 13 of of IN cord-335975-m6lkrehi 1596 14 body body NN cord-335975-m6lkrehi 1596 15 weight weight NN cord-335975-m6lkrehi 1596 16 variations variation NNS cord-335975-m6lkrehi 1596 17 ( ( -LRB- cord-335975-m6lkrehi 1596 18 BWV BWV NNP cord-335975-m6lkrehi 1596 19 ) ) -RRB- cord-335975-m6lkrehi 1596 20 from from IN cord-335975-m6lkrehi 1596 21 Day day NN cord-335975-m6lkrehi 1596 22 3 3 CD cord-335975-m6lkrehi 1596 23 to to IN cord-335975-m6lkrehi 1596 24 Day day NN cord-335975-m6lkrehi 1596 25 7 7 CD cord-335975-m6lkrehi 1596 26 on on IN cord-335975-m6lkrehi 1596 27 the the DT cord-335975-m6lkrehi 1596 28 30-day 30-day CD cord-335975-m6lkrehi 1596 29 mortality mortality NN cord-335975-m6lkrehi 1596 30 , , , cord-335975-m6lkrehi 1596 31 length length NN cord-335975-m6lkrehi 1596 32 of of IN cord-335975-m6lkrehi 1596 33 stay stay NN cord-335975-m6lkrehi 1596 34 ( ( -LRB- cord-335975-m6lkrehi 1596 35 LOS LOS NNP cord-335975-m6lkrehi 1596 36 ) ) -RRB- cord-335975-m6lkrehi 1596 37 and and CC cord-335975-m6lkrehi 1596 38 the the DT cord-335975-m6lkrehi 1596 39 occurrence occurrence NN cord-335975-m6lkrehi 1596 40 of of IN cord-335975-m6lkrehi 1596 41 ventilator ventilator NN cord-335975-m6lkrehi 1596 42 - - HYPH cord-335975-m6lkrehi 1596 43 associated associate VBN cord-335975-m6lkrehi 1596 44 pneumonia pneumonia NN cord-335975-m6lkrehi 1596 45 ( ( -LRB- cord-335975-m6lkrehi 1596 46 VAP VAP NNP cord-335975-m6lkrehi 1596 47 ) ) -RRB- cord-335975-m6lkrehi 1596 48 and and CC cord-335975-m6lkrehi 1596 49 bedsore bedsore NN cord-335975-m6lkrehi 1596 50 in in IN cord-335975-m6lkrehi 1596 51 critically critically RB cord-335975-m6lkrehi 1596 52 ill ill JJ cord-335975-m6lkrehi 1596 53 patients patient NNS cord-335975-m6lkrehi 1596 54 with with IN cord-335975-m6lkrehi 1596 55 shock shock NN cord-335975-m6lkrehi 1596 56 . . . cord-335975-m6lkrehi 1597 1 Patients patient NNS cord-335975-m6lkrehi 1597 2 and and CC cord-335975-m6lkrehi 1597 3 methods method NNS cord-335975-m6lkrehi 1597 4 : : : cord-335975-m6lkrehi 1597 5 Adult adult NN cord-335975-m6lkrehi 1597 6 patients patient NNS cord-335975-m6lkrehi 1597 7 admitted admit VBD cord-335975-m6lkrehi 1597 8 in in IN cord-335975-m6lkrehi 1597 9 ICU ICU NNP cord-335975-m6lkrehi 1597 10 with with IN cord-335975-m6lkrehi 1597 11 shock shock NN cord-335975-m6lkrehi 1597 12 between between IN cord-335975-m6lkrehi 1597 13 2002 2002 CD cord-335975-m6lkrehi 1597 14 and and CC cord-335975-m6lkrehi 1597 15 2012 2012 CD cord-335975-m6lkrehi 1597 16 , , , cord-335975-m6lkrehi 1597 17 and and CC cord-335975-m6lkrehi 1597 18 requiring require VBG cord-335975-m6lkrehi 1597 19 mechanical mechanical JJ cord-335975-m6lkrehi 1597 20 ventilation ventilation NN cord-335975-m6lkrehi 1597 21 during during IN cord-335975-m6lkrehi 1597 22 the the DT cord-335975-m6lkrehi 1597 23 first first JJ cord-335975-m6lkrehi 1597 24 48 48 CD cord-335975-m6lkrehi 1597 25 h h NN cord-335975-m6lkrehi 1597 26 , , , cord-335975-m6lkrehi 1597 27 were be VBD cord-335975-m6lkrehi 1597 28 extracted extract VBN cord-335975-m6lkrehi 1597 29 from from IN cord-335975-m6lkrehi 1597 30 a a DT cord-335975-m6lkrehi 1597 31 prospective prospective JJ cord-335975-m6lkrehi 1597 32 multicenter multicenter JJ cord-335975-m6lkrehi 1597 33 cohort cohort NN cord-335975-m6lkrehi 1597 34 for for IN cord-335975-m6lkrehi 1597 35 a a DT cord-335975-m6lkrehi 1597 36 retrospective retrospective JJ cord-335975-m6lkrehi 1597 37 analysis analysis NN cord-335975-m6lkrehi 1597 38 . . . cord-335975-m6lkrehi 1598 1 BWV BWV NNP cord-335975-m6lkrehi 1598 2 was be VBD cord-335975-m6lkrehi 1598 3 defined define VBN cord-335975-m6lkrehi 1598 4 as as IN cord-335975-m6lkrehi 1598 5 the the DT cord-335975-m6lkrehi 1598 6 difference difference NN cord-335975-m6lkrehi 1598 7 between between IN cord-335975-m6lkrehi 1598 8 the the DT cord-335975-m6lkrehi 1598 9 body body NN cord-335975-m6lkrehi 1598 10 weight weight NN cord-335975-m6lkrehi 1598 11 of of IN cord-335975-m6lkrehi 1598 12 the the DT cord-335975-m6lkrehi 1598 13 day day NN cord-335975-m6lkrehi 1598 14 of of IN cord-335975-m6lkrehi 1598 15 interest interest NN cord-335975-m6lkrehi 1598 16 and and CC cord-335975-m6lkrehi 1598 17 the the DT cord-335975-m6lkrehi 1598 18 body body NN cord-335975-m6lkrehi 1598 19 weight weight NN cord-335975-m6lkrehi 1598 20 on on IN cord-335975-m6lkrehi 1598 21 admission admission NN cord-335975-m6lkrehi 1598 22 . . . cord-335975-m6lkrehi 1599 1 Case case NN cord-335975-m6lkrehi 1599 2 mix mix NN cord-335975-m6lkrehi 1599 3 , , , cord-335975-m6lkrehi 1599 4 severity severity NN cord-335975-m6lkrehi 1599 5 on on IN cord-335975-m6lkrehi 1599 6 admission admission NN cord-335975-m6lkrehi 1599 7 , , , cord-335975-m6lkrehi 1599 8 and and CC cord-335975-m6lkrehi 1599 9 outcomes outcome NNS cord-335975-m6lkrehi 1599 10 were be VBD cord-335975-m6lkrehi 1599 11 collected collect VBN cord-335975-m6lkrehi 1599 12 . . . cord-335975-m6lkrehi 1600 1 Fine fine JJ cord-335975-m6lkrehi 1600 2 and and CC cord-335975-m6lkrehi 1600 3 Gray gray JJ cord-335975-m6lkrehi 1600 4 sub sub NN cord-335975-m6lkrehi 1600 5 - - JJ cord-335975-m6lkrehi 1600 6 distribution distribution JJ cord-335975-m6lkrehi 1600 7 survival survival NN cord-335975-m6lkrehi 1600 8 models model NNS cord-335975-m6lkrehi 1600 9 were be VBD cord-335975-m6lkrehi 1600 10 used use VBN cord-335975-m6lkrehi 1600 11 , , , cord-335975-m6lkrehi 1600 12 with with IN cord-335975-m6lkrehi 1600 13 ICU ICU NNP cord-335975-m6lkrehi 1600 14 discharge discharge NN cord-335975-m6lkrehi 1600 15 as as IN cord-335975-m6lkrehi 1600 16 competing compete VBG cord-335975-m6lkrehi 1600 17 event event NN cord-335975-m6lkrehi 1600 18 , , , cord-335975-m6lkrehi 1600 19 adjusted adjust VBN cord-335975-m6lkrehi 1600 20 on on IN cord-335975-m6lkrehi 1600 21 comorbidity comorbidity NN cord-335975-m6lkrehi 1600 22 and and CC cord-335975-m6lkrehi 1600 23 illness illness NN cord-335975-m6lkrehi 1600 24 severity severity NN cord-335975-m6lkrehi 1600 25 at at IN cord-335975-m6lkrehi 1600 26 admission admission NN cord-335975-m6lkrehi 1600 27 at at IN cord-335975-m6lkrehi 1600 28 each each DT cord-335975-m6lkrehi 1600 29 landmark landmark NN cord-335975-m6lkrehi 1600 30 , , , cord-335975-m6lkrehi 1600 31 from from IN cord-335975-m6lkrehi 1600 32 Day day NN cord-335975-m6lkrehi 1600 33 3 3 CD cord-335975-m6lkrehi 1600 34 to to IN cord-335975-m6lkrehi 1600 35 Day day NN cord-335975-m6lkrehi 1600 36 7 7 CD cord-335975-m6lkrehi 1600 37 . . . cord-335975-m6lkrehi 1601 1 The the DT cord-335975-m6lkrehi 1601 2 impact impact NN cord-335975-m6lkrehi 1601 3 of of IN cord-335975-m6lkrehi 1601 4 BWV BWV NNP cord-335975-m6lkrehi 1601 5 on on IN cord-335975-m6lkrehi 1601 6 ICU ICU NNP cord-335975-m6lkrehi 1601 7 stay stay NN cord-335975-m6lkrehi 1601 8 duration duration NN cord-335975-m6lkrehi 1601 9 was be VBD cord-335975-m6lkrehi 1601 10 estimated estimate VBN cord-335975-m6lkrehi 1601 11 through through IN cord-335975-m6lkrehi 1601 12 a a DT cord-335975-m6lkrehi 1601 13 multivariate multivariate JJ cord-335975-m6lkrehi 1601 14 negative negative JJ cord-335975-m6lkrehi 1601 15 binomial binomial JJ cord-335975-m6lkrehi 1601 16 regression regression NN cord-335975-m6lkrehi 1601 17 model model NN cord-335975-m6lkrehi 1601 18 . . . cord-335975-m6lkrehi 1602 1 The the DT cord-335975-m6lkrehi 1602 2 median median JJ cord-335975-m6lkrehi 1602 3 age age NN cord-335975-m6lkrehi 1602 4 and and CC cord-335975-m6lkrehi 1602 5 SAPS saps NN cord-335975-m6lkrehi 1602 6 2 2 CD cord-335975-m6lkrehi 1602 7 score score NN cord-335975-m6lkrehi 1602 8 of of IN cord-335975-m6lkrehi 1602 9 the the DT cord-335975-m6lkrehi 1602 10 2 2 CD cord-335975-m6lkrehi 1602 11 374 374 CD cord-335975-m6lkrehi 1602 12 included include VBD cord-335975-m6lkrehi 1602 13 patients patient NNS cord-335975-m6lkrehi 1602 14 were be VBD cord-335975-m6lkrehi 1602 15 67 67 CD cord-335975-m6lkrehi 1603 1 ( ( -LRB- cord-335975-m6lkrehi 1603 2 IQR IQR NNP cord-335975-m6lkrehi 1603 3 , , , cord-335975-m6lkrehi 1603 4 55 55 CD cord-335975-m6lkrehi 1603 5 - - SYM cord-335975-m6lkrehi 1603 6 77 77 CD cord-335975-m6lkrehi 1603 7 ) ) -RRB- cord-335975-m6lkrehi 1603 8 years year NNS cord-335975-m6lkrehi 1603 9 and and CC cord-335975-m6lkrehi 1603 10 53 53 CD cord-335975-m6lkrehi 1603 11 ( ( -LRB- cord-335975-m6lkrehi 1603 12 IQR IQR NNP cord-335975-m6lkrehi 1603 13 , , , cord-335975-m6lkrehi 1603 14 41 41 CD cord-335975-m6lkrehi 1603 15 - - SYM cord-335975-m6lkrehi 1603 16 65 65 CD cord-335975-m6lkrehi 1603 17 ) ) -RRB- cord-335975-m6lkrehi 1603 18 , , , cord-335975-m6lkrehi 1603 19 respectively respectively RB cord-335975-m6lkrehi 1603 20 . . . cord-335975-m6lkrehi 1604 1 The the DT cord-335975-m6lkrehi 1604 2 BWV BWV NNP cord-335975-m6lkrehi 1604 3 increased increase VBD cord-335975-m6lkrehi 1604 4 from from IN cord-335975-m6lkrehi 1604 5 0.4 0.4 CD cord-335975-m6lkrehi 1604 6 kg kg NNS cord-335975-m6lkrehi 1604 7 ( ( -LRB- cord-335975-m6lkrehi 1604 8 IQR IQR NNP cord-335975-m6lkrehi 1604 9 , , , cord-335975-m6lkrehi 1604 10 0 0 CD cord-335975-m6lkrehi 1604 11 - - SYM cord-335975-m6lkrehi 1604 12 4.8 4.8 CD cord-335975-m6lkrehi 1604 13 ) ) -RRB- cord-335975-m6lkrehi 1604 14 on on IN cord-335975-m6lkrehi 1604 15 Day Day NNP cord-335975-m6lkrehi 1604 16 3 3 CD cord-335975-m6lkrehi 1604 17 to to IN cord-335975-m6lkrehi 1604 18 3 3 CD cord-335975-m6lkrehi 1604 19 kg kg NN cord-335975-m6lkrehi 1604 20 ( ( -LRB- cord-335975-m6lkrehi 1604 21 IQR IQR NNP cord-335975-m6lkrehi 1604 22 , , , cord-335975-m6lkrehi 1604 23 − − NNP cord-335975-m6lkrehi 1604 24 0.4 0.4 CD cord-335975-m6lkrehi 1604 25 to to IN cord-335975-m6lkrehi 1604 26 8.2 8.2 CD cord-335975-m6lkrehi 1604 27 ) ) -RRB- cord-335975-m6lkrehi 1604 28 on on IN cord-335975-m6lkrehi 1604 29 Day Day NNP cord-335975-m6lkrehi 1604 30 7 7 CD cord-335975-m6lkrehi 1604 31 . . . cord-335975-m6lkrehi 1605 1 The the DT cord-335975-m6lkrehi 1605 2 30 30 CD cord-335975-m6lkrehi 1605 3 day day NN cord-335975-m6lkrehi 1605 4 in in IN cord-335975-m6lkrehi 1605 5 - - HYPH cord-335975-m6lkrehi 1605 6 hospital hospital NN cord-335975-m6lkrehi 1605 7 mortality mortality NN cord-335975-m6lkrehi 1605 8 , , , cord-335975-m6lkrehi 1605 9 the the DT cord-335975-m6lkrehi 1605 10 ICU ICU NNP cord-335975-m6lkrehi 1605 11 occurrence occurrence NN cord-335975-m6lkrehi 1605 12 of of IN cord-335975-m6lkrehi 1605 13 bedsore bedsore NN cord-335975-m6lkrehi 1605 14 and and CC cord-335975-m6lkrehi 1605 15 VAP VAP NNP cord-335975-m6lkrehi 1605 16 were be VBD cord-335975-m6lkrehi 1605 17 27 27 CD cord-335975-m6lkrehi 1605 18 , , , cord-335975-m6lkrehi 1605 19 3 3 CD cord-335975-m6lkrehi 1605 20 and and CC cord-335975-m6lkrehi 1605 21 19.6 19.6 CD cord-335975-m6lkrehi 1605 22 % % NN cord-335975-m6lkrehi 1605 23 , , , cord-335975-m6lkrehi 1605 24 respectively respectively RB cord-335975-m6lkrehi 1605 25 . . . cord-335975-m6lkrehi 1606 1 Four four CD cord-335975-m6lkrehi 1606 2 categories category NNS cord-335975-m6lkrehi 1606 3 of of IN cord-335975-m6lkrehi 1606 4 BWV BWV NNP cord-335975-m6lkrehi 1606 5 were be VBD cord-335975-m6lkrehi 1606 6 defined define VBN cord-335975-m6lkrehi 1606 7 according accord VBG cord-335975-m6lkrehi 1606 8 to to IN cord-335975-m6lkrehi 1606 9 BWV BWV NNP cord-335975-m6lkrehi 1606 10 interquartiles interquartile NNS cord-335975-m6lkrehi 1606 11 : : : cord-335975-m6lkrehi 1606 12 weight weight NN cord-335975-m6lkrehi 1606 13 loss loss NN cord-335975-m6lkrehi 1606 14 , , , cord-335975-m6lkrehi 1606 15 stable stable JJ cord-335975-m6lkrehi 1606 16 weight weight NN cord-335975-m6lkrehi 1606 17 , , , cord-335975-m6lkrehi 1606 18 moderate moderate JJ cord-335975-m6lkrehi 1606 19 and and CC cord-335975-m6lkrehi 1606 20 severe severe JJ cord-335975-m6lkrehi 1606 21 weight weight NN cord-335975-m6lkrehi 1606 22 gain gain NN cord-335975-m6lkrehi 1606 23 . . . cord-335975-m6lkrehi 1607 1 Categories category NNS cord-335975-m6lkrehi 1607 2 of of IN cord-335975-m6lkrehi 1607 3 BWV BWV NNP cord-335975-m6lkrehi 1607 4 were be VBD cord-335975-m6lkrehi 1607 5 independently independently RB cord-335975-m6lkrehi 1607 6 associated associate VBN cord-335975-m6lkrehi 1607 7 with with IN cord-335975-m6lkrehi 1607 8 death death NN cord-335975-m6lkrehi 1607 9 on on IN cord-335975-m6lkrehi 1607 10 Day Day NNP cord-335975-m6lkrehi 1607 11 5 5 CD cord-335975-m6lkrehi 1607 12 and and CC cord-335975-m6lkrehi 1607 13 Day Day NNP cord-335975-m6lkrehi 1607 14 6 6 CD cord-335975-m6lkrehi 1608 1 ( ( -LRB- cord-335975-m6lkrehi 1608 2 Day day NN cord-335975-m6lkrehi 1608 3 5 5 CD cord-335975-m6lkrehi 1608 4 : : : cord-335975-m6lkrehi 1608 5 sHR shr CD cord-335975-m6lkrehi 1608 6 1.27 1.27 CD cord-335975-m6lkrehi 1608 7 ; ; : cord-335975-m6lkrehi 1608 8 95 95 CD cord-335975-m6lkrehi 1608 9 % % NN cord-335975-m6lkrehi 1608 10 0.99 0.99 CD cord-335975-m6lkrehi 1608 11 - - HYPH cord-335975-m6lkrehi 1608 12 1.63 1.63 CD cord-335975-m6lkrehi 1608 13 p p NN cord-335975-m6lkrehi 1608 14 = = SYM cord-335975-m6lkrehi 1608 15 0.06 0.06 CD cord-335975-m6lkrehi 1608 16 ; ; . cord-335975-m6lkrehi 1609 1 Day day NN cord-335975-m6lkrehi 1609 2 6 6 CD cord-335975-m6lkrehi 1609 3 : : : cord-335975-m6lkrehi 1609 4 sHR shr CD cord-335975-m6lkrehi 1609 5 1.43 1.43 CD cord-335975-m6lkrehi 1609 6 ; ; : cord-335975-m6lkrehi 1609 7 95 95 CD cord-335975-m6lkrehi 1609 8 % % NN cord-335975-m6lkrehi 1609 9 CI CI NNP cord-335975-m6lkrehi 1609 10 1.08 1.08 CD cord-335975-m6lkrehi 1609 11 - - SYM cord-335975-m6lkrehi 1609 12 1.89 1.89 CD cord-335975-m6lkrehi 1609 13 , , , cord-335975-m6lkrehi 1609 14 p p NN cord-335975-m6lkrehi 1609 15 = = SYM cord-335975-m6lkrehi 1609 16 0.01 0.01 CD cord-335975-m6lkrehi 1609 17 ) ) -RRB- cord-335975-m6lkrehi 1610 1 ( ( -LRB- cord-335975-m6lkrehi 1610 2 Fig Fig NNP cord-335975-m6lkrehi 1610 3 . . NNP cord-335975-m6lkrehi 1610 4 1 1 CD cord-335975-m6lkrehi 1610 5 ) ) -RRB- cord-335975-m6lkrehi 1610 6 . . . cord-335975-m6lkrehi 1611 1 A a DT cord-335975-m6lkrehi 1611 2 weight weight NN cord-335975-m6lkrehi 1611 3 loss loss NN cord-335975-m6lkrehi 1611 4 tended tend VBD cord-335975-m6lkrehi 1611 5 to to TO cord-335975-m6lkrehi 1611 6 be be VB cord-335975-m6lkrehi 1611 7 associated associate VBN cord-335975-m6lkrehi 1611 8 with with IN cord-335975-m6lkrehi 1611 9 increased increase VBN cord-335975-m6lkrehi 1611 10 occurrence occurrence NN cord-335975-m6lkrehi 1611 11 of of IN cord-335975-m6lkrehi 1611 12 bedsore bedsore NN cord-335975-m6lkrehi 1611 13 , , , cord-335975-m6lkrehi 1611 14 and and CC cord-335975-m6lkrehi 1611 15 weight weight NN cord-335975-m6lkrehi 1611 16 gain gain NN cord-335975-m6lkrehi 1611 17 with with IN cord-335975-m6lkrehi 1611 18 increased increase VBN cord-335975-m6lkrehi 1611 19 occurrence occurrence NN cord-335975-m6lkrehi 1611 20 of of IN cord-335975-m6lkrehi 1611 21 VAP VAP NNP cord-335975-m6lkrehi 1611 22 . . . cord-335975-m6lkrehi 1612 1 The the DT cord-335975-m6lkrehi 1612 2 extent extent NN cord-335975-m6lkrehi 1612 3 of of IN cord-335975-m6lkrehi 1612 4 BWV BWV NNP cord-335975-m6lkrehi 1612 5 increased increase VBD cord-335975-m6lkrehi 1612 6 the the DT cord-335975-m6lkrehi 1612 7 duration duration NN cord-335975-m6lkrehi 1612 8 of of IN cord-335975-m6lkrehi 1612 9 ICU ICU NNP cord-335975-m6lkrehi 1612 10 stay stay VBP cord-335975-m6lkrehi 1612 11 independently independently RB cord-335975-m6lkrehi 1612 12 of of IN cord-335975-m6lkrehi 1612 13 other other JJ cord-335975-m6lkrehi 1612 14 severity severity NN cord-335975-m6lkrehi 1612 15 factors factor NNS cord-335975-m6lkrehi 1612 16 . . . cord-335975-m6lkrehi 1613 1 Discussion discussion NN cord-335975-m6lkrehi 1613 2 : : : cord-335975-m6lkrehi 1614 1 BWV BWV NNP cord-335975-m6lkrehi 1614 2 may may MD cord-335975-m6lkrehi 1614 3 be be VB cord-335975-m6lkrehi 1614 4 another another DT cord-335975-m6lkrehi 1614 5 clinically clinically RB cord-335975-m6lkrehi 1614 6 relevant relevant JJ cord-335975-m6lkrehi 1614 7 tool tool NN cord-335975-m6lkrehi 1614 8 to to TO cord-335975-m6lkrehi 1614 9 assess assess VB cord-335975-m6lkrehi 1614 10 the the DT cord-335975-m6lkrehi 1614 11 risk risk NN cord-335975-m6lkrehi 1614 12 of of IN cord-335975-m6lkrehi 1614 13 death death NN cord-335975-m6lkrehi 1614 14 , , , cord-335975-m6lkrehi 1614 15 mostly mostly RB cord-335975-m6lkrehi 1614 16 after after IN cord-335975-m6lkrehi 1614 17 Day day NN cord-335975-m6lkrehi 1614 18 4 4 CD cord-335975-m6lkrehi 1614 19 . . . cord-335975-m6lkrehi 1615 1 The the DT cord-335975-m6lkrehi 1615 2 increased increased JJ cord-335975-m6lkrehi 1615 3 risk risk NN cord-335975-m6lkrehi 1615 4 of of IN cord-335975-m6lkrehi 1615 5 bedsore bedsore NN cord-335975-m6lkrehi 1615 6 in in IN cord-335975-m6lkrehi 1615 7 case case NN cord-335975-m6lkrehi 1615 8 of of IN cord-335975-m6lkrehi 1615 9 weight weight NN cord-335975-m6lkrehi 1615 10 loss loss NN cord-335975-m6lkrehi 1615 11 deserved deserve VBN cord-335975-m6lkrehi 1615 12 to to TO cord-335975-m6lkrehi 1615 13 be be VB cord-335975-m6lkrehi 1615 14 confirmed confirm VBN cord-335975-m6lkrehi 1615 15 . . . cord-335975-m6lkrehi 1616 1 Conclusion conclusion NN cord-335975-m6lkrehi 1616 2 : : : cord-335975-m6lkrehi 1616 3 Body body NN cord-335975-m6lkrehi 1616 4 weight weight NN cord-335975-m6lkrehi 1616 5 should should MD cord-335975-m6lkrehi 1616 6 be be VB cord-335975-m6lkrehi 1616 7 daily daily RB cord-335975-m6lkrehi 1616 8 monitored monitor VBN cord-335975-m6lkrehi 1616 9 for for IN cord-335975-m6lkrehi 1616 10 better well JJR cord-335975-m6lkrehi 1616 11 prognostication prognostication NN cord-335975-m6lkrehi 1616 12 . . . cord-335975-m6lkrehi 1617 1 BWV BWV NNP cord-335975-m6lkrehi 1617 2 - - HYPH cord-335975-m6lkrehi 1617 3 based base VBN cord-335975-m6lkrehi 1617 4 restrictive restrictive JJ cord-335975-m6lkrehi 1617 5 strategies strategy NNS cord-335975-m6lkrehi 1617 6 should should MD cord-335975-m6lkrehi 1617 7 be be VB cord-335975-m6lkrehi 1617 8 further further RB cord-335975-m6lkrehi 1617 9 evaluated evaluate VBN cord-335975-m6lkrehi 1617 10 . . . cord-335975-m6lkrehi 1618 1 The the DT cord-335975-m6lkrehi 1618 2 clinical clinical JJ cord-335975-m6lkrehi 1618 3 effectiveness effectiveness NN cord-335975-m6lkrehi 1618 4 of of IN cord-335975-m6lkrehi 1618 5 multi multi JJ cord-335975-m6lkrehi 1618 6 - - JJ cord-335975-m6lkrehi 1618 7 layer layer NN cord-335975-m6lkrehi 1618 8 silicone silicone NN cord-335975-m6lkrehi 1618 9 dressings dressing NNS cord-335975-m6lkrehi 1618 10 in in IN cord-335975-m6lkrehi 1618 11 preventing prevent VBG cord-335975-m6lkrehi 1618 12 ICU ICU NNP cord-335975-m6lkrehi 1618 13 acquired acquire VBD cord-335975-m6lkrehi 1618 14 pressure pressure NN cord-335975-m6lkrehi 1618 15 ulcers ulcer NNS cord-335975-m6lkrehi 1618 16 : : : cord-335975-m6lkrehi 1619 1 a a DT cord-335975-m6lkrehi 1619 2 randomised randomised JJ cord-335975-m6lkrehi 1619 3 controlled control VBN cord-335975-m6lkrehi 1619 4 trial trial NN cord-335975-m6lkrehi 1619 5 Introduction introduction NN cord-335975-m6lkrehi 1619 6 : : : cord-335975-m6lkrehi 1620 1 The the DT cord-335975-m6lkrehi 1620 2 development development NN cord-335975-m6lkrehi 1620 3 of of IN cord-335975-m6lkrehi 1620 4 pressure pressure NN cord-335975-m6lkrehi 1620 5 ulcers ulcer NNS cord-335975-m6lkrehi 1620 6 ( ( -LRB- cord-335975-m6lkrehi 1620 7 PU PU NNP cord-335975-m6lkrehi 1620 8 ) ) -RRB- cord-335975-m6lkrehi 1620 9 in in IN cord-335975-m6lkrehi 1620 10 critically critically RB cord-335975-m6lkrehi 1620 11 ill ill JJ cord-335975-m6lkrehi 1620 12 ICU ICU NNP cord-335975-m6lkrehi 1620 13 patients patient NNS cord-335975-m6lkrehi 1620 14 result result VBP cord-335975-m6lkrehi 1620 15 in in IN cord-335975-m6lkrehi 1620 16 additional additional JJ cord-335975-m6lkrehi 1620 17 morbidity morbidity NN cord-335975-m6lkrehi 1620 18 and and CC cord-335975-m6lkrehi 1620 19 may may MD cord-335975-m6lkrehi 1620 20 contribute contribute VB cord-335975-m6lkrehi 1620 21 to to IN cord-335975-m6lkrehi 1620 22 mortality mortality NN cord-335975-m6lkrehi 1620 23 in in IN cord-335975-m6lkrehi 1620 24 some some DT cord-335975-m6lkrehi 1620 25 cases case NNS cord-335975-m6lkrehi 1620 26 . . . cord-335975-m6lkrehi 1621 1 The the DT cord-335975-m6lkrehi 1621 2 minimisation minimisation NN cord-335975-m6lkrehi 1621 3 of of IN cord-335975-m6lkrehi 1621 4 ICU ICU NNP cord-335975-m6lkrehi 1621 5 acquired acquire VBD cord-335975-m6lkrehi 1621 6 PU PU NNP cord-335975-m6lkrehi 1621 7 remain remain VBP cord-335975-m6lkrehi 1621 8 an an DT cord-335975-m6lkrehi 1621 9 international international JJ cord-335975-m6lkrehi 1621 10 challenge challenge NN cord-335975-m6lkrehi 1621 11 . . . cord-335975-m6lkrehi 1622 1 This this DT cord-335975-m6lkrehi 1622 2 paper paper NN cord-335975-m6lkrehi 1622 3 describes describe VBZ cord-335975-m6lkrehi 1622 4 Australian australian JJ cord-335975-m6lkrehi 1622 5 research research NN cord-335975-m6lkrehi 1622 6 that that WDT cord-335975-m6lkrehi 1622 7 used use VBD cord-335975-m6lkrehi 1622 8 multi multi JJ cord-335975-m6lkrehi 1622 9 - - JJ cord-335975-m6lkrehi 1622 10 layer layer JJ cord-335975-m6lkrehi 1622 11 soft soft JJ cord-335975-m6lkrehi 1622 12 silicone silicone NN cord-335975-m6lkrehi 1622 13 sacral sacral JJ cord-335975-m6lkrehi 1622 14 and and CC cord-335975-m6lkrehi 1622 15 heel heel VB cord-335975-m6lkrehi 1622 16 dressings dressing NNS cord-335975-m6lkrehi 1622 17 to to TO cord-335975-m6lkrehi 1622 18 prevent prevent VB cord-335975-m6lkrehi 1622 19 PU PU NNP cord-335975-m6lkrehi 1622 20 in in IN cord-335975-m6lkrehi 1622 21 critically critically RB cord-335975-m6lkrehi 1622 22 ill ill JJ cord-335975-m6lkrehi 1622 23 patients patient NNS cord-335975-m6lkrehi 1622 24 . . . cord-335975-m6lkrehi 1623 1 Patients patient NNS cord-335975-m6lkrehi 1623 2 and and CC cord-335975-m6lkrehi 1623 3 methods method NNS cord-335975-m6lkrehi 1623 4 : : : cord-335975-m6lkrehi 1623 5 A a DT cord-335975-m6lkrehi 1623 6 total total NN cord-335975-m6lkrehi 1623 7 of of IN cord-335975-m6lkrehi 1623 8 440 440 CD cord-335975-m6lkrehi 1623 9 critically critically RB cord-335975-m6lkrehi 1623 10 ill ill JJ cord-335975-m6lkrehi 1623 11 patients patient NNS cord-335975-m6lkrehi 1623 12 were be VBD cord-335975-m6lkrehi 1623 13 enrolled enrol VBN cord-335975-m6lkrehi 1623 14 into into IN cord-335975-m6lkrehi 1623 15 an an DT cord-335975-m6lkrehi 1623 16 18-month 18-month JJ cord-335975-m6lkrehi 1623 17 randomised randomised JJ cord-335975-m6lkrehi 1623 18 controlled control VBN cord-335975-m6lkrehi 1623 19 trial trial NN cord-335975-m6lkrehi 1623 20 in in IN cord-335975-m6lkrehi 1623 21 one one CD cord-335975-m6lkrehi 1623 22 of of IN cord-335975-m6lkrehi 1623 23 Melbourne Melbourne NNP cord-335975-m6lkrehi 1623 24 's 's POS cord-335975-m6lkrehi 1623 25 trauma trauma NN cord-335975-m6lkrehi 1623 26 centres centre NNS cord-335975-m6lkrehi 1623 27 . . . cord-335975-m6lkrehi 1624 1 Patients patient NNS cord-335975-m6lkrehi 1624 2 were be VBD cord-335975-m6lkrehi 1624 3 randomised randomise VBN cord-335975-m6lkrehi 1624 4 on on IN cord-335975-m6lkrehi 1624 5 admission admission NN cord-335975-m6lkrehi 1624 6 to to IN cord-335975-m6lkrehi 1624 7 the the DT cord-335975-m6lkrehi 1624 8 Emergency Emergency NNP cord-335975-m6lkrehi 1624 9 Department Department NNP cord-335975-m6lkrehi 1624 10 and and CC cord-335975-m6lkrehi 1624 11 either either RB cord-335975-m6lkrehi 1624 12 had have VBD cord-335975-m6lkrehi 1624 13 standard standard JJ cord-335975-m6lkrehi 1624 14 PU PU NNP cord-335975-m6lkrehi 1624 15 prevention prevention NN cord-335975-m6lkrehi 1624 16 or or CC cord-335975-m6lkrehi 1624 17 standard standard JJ cord-335975-m6lkrehi 1624 18 care care NN cord-335975-m6lkrehi 1624 19 plus plus CC cord-335975-m6lkrehi 1624 20 the the DT cord-335975-m6lkrehi 1624 21 application application NN cord-335975-m6lkrehi 1624 22 of of IN cord-335975-m6lkrehi 1624 23 prophylactic prophylactic JJ cord-335975-m6lkrehi 1624 24 sacral sacral JJ cord-335975-m6lkrehi 1624 25 and and CC cord-335975-m6lkrehi 1624 26 heel heel NN cord-335975-m6lkrehi 1624 27 dressings dressing NNS cord-335975-m6lkrehi 1624 28 . . . cord-335975-m6lkrehi 1625 1 Patients patient NNS cord-335975-m6lkrehi 1625 2 were be VBD cord-335975-m6lkrehi 1625 3 observed observe VBN cord-335975-m6lkrehi 1625 4 daily daily RB cord-335975-m6lkrehi 1625 5 for for IN cord-335975-m6lkrehi 1625 6 PU PU NNP cord-335975-m6lkrehi 1625 7 development development NN cord-335975-m6lkrehi 1625 8 for for IN cord-335975-m6lkrehi 1625 9 the the DT cord-335975-m6lkrehi 1625 10 duration duration NN cord-335975-m6lkrehi 1625 11 of of IN cord-335975-m6lkrehi 1625 12 their -PRON- PRP$ cord-335975-m6lkrehi 1625 13 ICU ICU NNP cord-335975-m6lkrehi 1625 14 stay stay NN cord-335975-m6lkrehi 1625 15 . . . cord-335975-m6lkrehi 1626 1 Results result NNS cord-335975-m6lkrehi 1626 2 : : : cord-335975-m6lkrehi 1627 1 Patients patient NNS cord-335975-m6lkrehi 1627 2 in in IN cord-335975-m6lkrehi 1627 3 the the DT cord-335975-m6lkrehi 1627 4 dressing dressing NN cord-335975-m6lkrehi 1627 5 group group NN cord-335975-m6lkrehi 1627 6 has have VBZ cord-335975-m6lkrehi 1627 7 significantly significantly RB cord-335975-m6lkrehi 1627 8 reduced reduce VBN cord-335975-m6lkrehi 1627 9 incidence incidence NN cord-335975-m6lkrehi 1627 10 rate rate NN cord-335975-m6lkrehi 1627 11 of of IN cord-335975-m6lkrehi 1627 12 PU PU NNP cord-335975-m6lkrehi 1627 13 development development NN cord-335975-m6lkrehi 1627 14 compared compare VBN cord-335975-m6lkrehi 1627 15 to to IN cord-335975-m6lkrehi 1627 16 patients patient NNS cord-335975-m6lkrehi 1627 17 receiving receive VBG cord-335975-m6lkrehi 1627 18 standard standard JJ cord-335975-m6lkrehi 1627 19 PU PU NNP cord-335975-m6lkrehi 1627 20 prevention prevention NN cord-335975-m6lkrehi 1627 21 alone alone RB cord-335975-m6lkrehi 1627 22 ( ( -LRB- cord-335975-m6lkrehi 1627 23 3.1 3.1 CD cord-335975-m6lkrehi 1627 24 vs vs IN cord-335975-m6lkrehi 1627 25 13.1 13.1 CD cord-335975-m6lkrehi 1627 26 % % NN cord-335975-m6lkrehi 1627 27 , , , cord-335975-m6lkrehi 1627 28 p p NN cord-335975-m6lkrehi 1627 29 < < XX cord-335975-m6lkrehi 1627 30 0.03 0.03 CD cord-335975-m6lkrehi 1627 31 ) ) -RRB- cord-335975-m6lkrehi 1627 32 . . . cord-335975-m6lkrehi 1628 1 Patients patient NNS cord-335975-m6lkrehi 1628 2 in in IN cord-335975-m6lkrehi 1628 3 the the DT cord-335975-m6lkrehi 1628 4 dressings dressing NNS cord-335975-m6lkrehi 1628 5 group group NN cord-335975-m6lkrehi 1628 6 had have VBD cord-335975-m6lkrehi 1628 7 a a DT cord-335975-m6lkrehi 1628 8 relative relative JJ cord-335975-m6lkrehi 1628 9 risk risk NN cord-335975-m6lkrehi 1628 10 reduction reduction NN cord-335975-m6lkrehi 1628 11 of of IN cord-335975-m6lkrehi 1628 12 80 80 CD cord-335975-m6lkrehi 1628 13 % % NN cord-335975-m6lkrehi 1628 14 and and CC cord-335975-m6lkrehi 1628 15 a a DT cord-335975-m6lkrehi 1628 16 10 10 CD cord-335975-m6lkrehi 1628 17 % % NN cord-335975-m6lkrehi 1628 18 absolute absolute JJ cord-335975-m6lkrehi 1628 19 risk risk NN cord-335975-m6lkrehi 1628 20 reduction reduction NN cord-335975-m6lkrehi 1628 21 for for IN cord-335975-m6lkrehi 1628 22 developing develop VBG cord-335975-m6lkrehi 1628 23 a a DT cord-335975-m6lkrehi 1628 24 PU PU NNP cord-335975-m6lkrehi 1628 25 regardless regardless RB cord-335975-m6lkrehi 1628 26 of of IN cord-335975-m6lkrehi 1628 27 their -PRON- PRP$ cord-335975-m6lkrehi 1628 28 critical critical JJ cord-335975-m6lkrehi 1628 29 illness illness NN cord-335975-m6lkrehi 1628 30 . . . cord-335975-m6lkrehi 1629 1 Results result NNS cord-335975-m6lkrehi 1629 2 indicate indicate VBP cord-335975-m6lkrehi 1629 3 the the DT cord-335975-m6lkrehi 1629 4 number number NN cord-335975-m6lkrehi 1629 5 needed need VBN cord-335975-m6lkrehi 1629 6 to to TO cord-335975-m6lkrehi 1629 7 treat treat VB cord-335975-m6lkrehi 1629 8 to to TO cord-335975-m6lkrehi 1629 9 prevent prevent VB cord-335975-m6lkrehi 1629 10 one one CD cord-335975-m6lkrehi 1629 11 PU PU NNP cord-335975-m6lkrehi 1629 12 was be VBD cord-335975-m6lkrehi 1629 13 10 10 CD cord-335975-m6lkrehi 1629 14 . . . cord-335975-m6lkrehi 1630 1 Additionally additionally RB cord-335975-m6lkrehi 1630 2 , , , cord-335975-m6lkrehi 1630 3 we -PRON- PRP cord-335975-m6lkrehi 1630 4 calculated calculate VBD cord-335975-m6lkrehi 1630 5 the the DT cord-335975-m6lkrehi 1630 6 cost cost NN cord-335975-m6lkrehi 1630 7 - - HYPH cord-335975-m6lkrehi 1630 8 benefit benefit NN cord-335975-m6lkrehi 1630 9 of of IN cord-335975-m6lkrehi 1630 10 this this DT cord-335975-m6lkrehi 1630 11 intervention intervention NN cord-335975-m6lkrehi 1630 12 and and CC cord-335975-m6lkrehi 1630 13 found find VBD cord-335975-m6lkrehi 1630 14 the the DT cord-335975-m6lkrehi 1630 15 patients patient NNS cord-335975-m6lkrehi 1630 16 treated treat VBN cord-335975-m6lkrehi 1630 17 with with IN cord-335975-m6lkrehi 1630 18 prophylactic prophylactic JJ cord-335975-m6lkrehi 1630 19 dressings dressing NNS cord-335975-m6lkrehi 1630 20 cost cost VBP cord-335975-m6lkrehi 1630 21 3.6 3.6 CD cord-335975-m6lkrehi 1630 22 time time NN cord-335975-m6lkrehi 1630 23 less less JJR cord-335975-m6lkrehi 1630 24 than than IN cord-335975-m6lkrehi 1630 25 the the DT cord-335975-m6lkrehi 1630 26 standard standard JJ cord-335975-m6lkrehi 1630 27 care care NN cord-335975-m6lkrehi 1630 28 group group NN cord-335975-m6lkrehi 1630 29 for for IN cord-335975-m6lkrehi 1630 30 wound wound JJ cord-335975-m6lkrehi 1630 31 care care NN cord-335975-m6lkrehi 1630 32 . . . cord-335975-m6lkrehi 1631 1 Discussion discussion NN cord-335975-m6lkrehi 1631 2 : : : cord-335975-m6lkrehi 1632 1 The the DT cord-335975-m6lkrehi 1632 2 use use NN cord-335975-m6lkrehi 1632 3 of of IN cord-335975-m6lkrehi 1632 4 prophylactic prophylactic JJ cord-335975-m6lkrehi 1632 5 dressings dressing NNS cord-335975-m6lkrehi 1632 6 to to TO cord-335975-m6lkrehi 1632 7 prevent prevent VB cord-335975-m6lkrehi 1632 8 PU PU NNP cord-335975-m6lkrehi 1632 9 at at IN cord-335975-m6lkrehi 1632 10 our -PRON- PRP$ cord-335975-m6lkrehi 1632 11 hospital hospital NN cord-335975-m6lkrehi 1632 12 have have VBP cord-335975-m6lkrehi 1632 13 proved prove VBN cord-335975-m6lkrehi 1632 14 to to TO cord-335975-m6lkrehi 1632 15 be be VB cord-335975-m6lkrehi 1632 16 very very RB cord-335975-m6lkrehi 1632 17 effective effective JJ cord-335975-m6lkrehi 1632 18 in in IN cord-335975-m6lkrehi 1632 19 ICU ICU NNP cord-335975-m6lkrehi 1632 20 and and CC cord-335975-m6lkrehi 1632 21 subsequent subsequent JJ cord-335975-m6lkrehi 1632 22 studies study NNS cord-335975-m6lkrehi 1632 23 have have VBP cord-335975-m6lkrehi 1632 24 confirmed confirm VBN cord-335975-m6lkrehi 1632 25 our -PRON- PRP$ cord-335975-m6lkrehi 1632 26 results result NNS cord-335975-m6lkrehi 1632 27 . . . cord-335975-m6lkrehi 1633 1 It -PRON- PRP cord-335975-m6lkrehi 1633 2 appears appear VBZ cord-335975-m6lkrehi 1633 3 that that IN cord-335975-m6lkrehi 1633 4 the the DT cord-335975-m6lkrehi 1633 5 main main JJ cord-335975-m6lkrehi 1633 6 mechanism mechanism NN cord-335975-m6lkrehi 1633 7 of of IN cord-335975-m6lkrehi 1633 8 PU PU NNP cord-335975-m6lkrehi 1633 9 protection protection NN cord-335975-m6lkrehi 1633 10 provided provide VBN cord-335975-m6lkrehi 1633 11 by by IN cord-335975-m6lkrehi 1633 12 these these DT cord-335975-m6lkrehi 1633 13 dressings dressing NNS cord-335975-m6lkrehi 1633 14 is be VBZ cord-335975-m6lkrehi 1633 15 the the DT cord-335975-m6lkrehi 1633 16 reduction reduction NN cord-335975-m6lkrehi 1633 17 of of IN cord-335975-m6lkrehi 1633 18 pressure pressure NN cord-335975-m6lkrehi 1633 19 and and CC cord-335975-m6lkrehi 1633 20 shear shear NN cord-335975-m6lkrehi 1633 21 forces force NNS cord-335975-m6lkrehi 1633 22 leading lead VBG cord-335975-m6lkrehi 1633 23 to to IN cord-335975-m6lkrehi 1633 24 tissue tissue NN cord-335975-m6lkrehi 1633 25 distortion distortion NN cord-335975-m6lkrehi 1633 26 and and CC cord-335975-m6lkrehi 1633 27 cell cell NN cord-335975-m6lkrehi 1633 28 death death NN cord-335975-m6lkrehi 1633 29 rather rather RB cord-335975-m6lkrehi 1633 30 than than IN cord-335975-m6lkrehi 1633 31 the the DT cord-335975-m6lkrehi 1633 32 previously previously RB cord-335975-m6lkrehi 1633 33 accepted accept VBN cord-335975-m6lkrehi 1633 34 ischaemic ischaemic JJ cord-335975-m6lkrehi 1633 35 model model NN cord-335975-m6lkrehi 1633 36 of of IN cord-335975-m6lkrehi 1633 37 PU PU NNP cord-335975-m6lkrehi 1633 38 development development NN cord-335975-m6lkrehi 1633 39 . . . cord-335975-m6lkrehi 1634 1 Our -PRON- PRP$ cord-335975-m6lkrehi 1634 2 current current JJ cord-335975-m6lkrehi 1634 3 policy policy NN cord-335975-m6lkrehi 1634 4 is be VBZ cord-335975-m6lkrehi 1634 5 now now RB cord-335975-m6lkrehi 1634 6 to to TO cord-335975-m6lkrehi 1634 7 use use VB cord-335975-m6lkrehi 1634 8 these these DT cord-335975-m6lkrehi 1634 9 dressings dressing NNS cord-335975-m6lkrehi 1634 10 on on IN cord-335975-m6lkrehi 1634 11 all all DT cord-335975-m6lkrehi 1634 12 patients patient NNS cord-335975-m6lkrehi 1634 13 with with IN cord-335975-m6lkrehi 1634 14 a a DT cord-335975-m6lkrehi 1634 15 high high JJ cord-335975-m6lkrehi 1634 16 risk risk NN cord-335975-m6lkrehi 1634 17 of of IN cord-335975-m6lkrehi 1634 18 developing develop VBG cord-335975-m6lkrehi 1634 19 PU PU NNP cord-335975-m6lkrehi 1634 20 . . . cord-335975-m6lkrehi 1635 1 The the DT cord-335975-m6lkrehi 1635 2 use use NN cord-335975-m6lkrehi 1635 3 of of IN cord-335975-m6lkrehi 1635 4 prophylactic prophylactic JJ cord-335975-m6lkrehi 1635 5 multi multi JJ cord-335975-m6lkrehi 1635 6 - - JJ cord-335975-m6lkrehi 1635 7 layer layer NN cord-335975-m6lkrehi 1635 8 silicone silicone NN cord-335975-m6lkrehi 1635 9 dressings dressing NNS cord-335975-m6lkrehi 1635 10 to to TO cord-335975-m6lkrehi 1635 11 prevent prevent VB cord-335975-m6lkrehi 1635 12 PU PU NNP cord-335975-m6lkrehi 1635 13 in in IN cord-335975-m6lkrehi 1635 14 critically critically RB cord-335975-m6lkrehi 1635 15 ill ill JJ cord-335975-m6lkrehi 1635 16 patients patient NNS cord-335975-m6lkrehi 1635 17 is be VBZ cord-335975-m6lkrehi 1635 18 effective effective JJ cord-335975-m6lkrehi 1635 19 but but CC cord-335975-m6lkrehi 1635 20 it -PRON- PRP cord-335975-m6lkrehi 1635 21 does do VBZ cord-335975-m6lkrehi 1635 22 not not RB cord-335975-m6lkrehi 1635 23 replace replace VB cord-335975-m6lkrehi 1635 24 standard standard JJ cord-335975-m6lkrehi 1635 25 PU PU NNP cord-335975-m6lkrehi 1635 26 prevention prevention NN cord-335975-m6lkrehi 1635 27 methods method NNS cord-335975-m6lkrehi 1635 28 . . . cord-335975-m6lkrehi 1636 1 The the DT cord-335975-m6lkrehi 1636 2 use use NN cord-335975-m6lkrehi 1636 3 of of IN cord-335975-m6lkrehi 1636 4 these these DT cord-335975-m6lkrehi 1636 5 dressings dressing NNS cord-335975-m6lkrehi 1636 6 sould sould MD cord-335975-m6lkrehi 1636 7 be be VB cord-335975-m6lkrehi 1636 8 considered consider VBN cord-335975-m6lkrehi 1636 9 complimentary complimentary JJ cord-335975-m6lkrehi 1636 10 to to IN cord-335975-m6lkrehi 1636 11 best good JJS cord-335975-m6lkrehi 1636 12 practice practice NN cord-335975-m6lkrehi 1636 13 in in IN cord-335975-m6lkrehi 1636 14 PU PU NNP cord-335975-m6lkrehi 1636 15 prevention prevention NN cord-335975-m6lkrehi 1636 16 . . . cord-335975-m6lkrehi 1637 1 Iatrogenic iatrogenic JJ cord-335975-m6lkrehi 1637 2 events event NNS cord-335975-m6lkrehi 1637 3 in in IN cord-335975-m6lkrehi 1637 4 intensive intensive JJ cord-335975-m6lkrehi 1637 5 care care NN cord-335975-m6lkrehi 1637 6 unit unit NN cord-335975-m6lkrehi 1637 7 : : : cord-335975-m6lkrehi 1637 8 incidence incidence NN cord-335975-m6lkrehi 1637 9 , , , cord-335975-m6lkrehi 1637 10 risk risk NN cord-335975-m6lkrehi 1637 11 factors factor NNS cord-335975-m6lkrehi 1637 12 and and CC cord-335975-m6lkrehi 1637 13 impact impact NN cord-335975-m6lkrehi 1637 14 on on IN cord-335975-m6lkrehi 1637 15 outcome outcome NN cord-335975-m6lkrehi 1638 1 Ayed Ayed NNP cord-335975-m6lkrehi 1638 2 Samia Samia NNP cord-335975-m6lkrehi 1638 3 1 1 CD cord-335975-m6lkrehi 1638 4 , , , cord-335975-m6lkrehi 1638 5 Merhebene Merhebene NNP cord-335975-m6lkrehi 1638 6 Takoua Takoua NNP cord-335975-m6lkrehi 1638 7 Introduction introduction NN cord-335975-m6lkrehi 1638 8 : : : cord-335975-m6lkrehi 1638 9 Iatrogenic iatrogenic JJ cord-335975-m6lkrehi 1638 10 events event NNS cord-335975-m6lkrehi 1638 11 ( ( -LRB- cord-335975-m6lkrehi 1638 12 IEs ie NNS cord-335975-m6lkrehi 1638 13 ) ) -RRB- cord-335975-m6lkrehi 1638 14 are be VBP cord-335975-m6lkrehi 1638 15 defined define VBN cord-335975-m6lkrehi 1638 16 as as IN cord-335975-m6lkrehi 1638 17 harm harm NN cord-335975-m6lkrehi 1638 18 resulting result VBG cord-335975-m6lkrehi 1638 19 from from IN cord-335975-m6lkrehi 1638 20 medical medical JJ cord-335975-m6lkrehi 1638 21 intervention intervention NN cord-335975-m6lkrehi 1638 22 and and CC cord-335975-m6lkrehi 1638 23 health health NN cord-335975-m6lkrehi 1638 24 care care NN cord-335975-m6lkrehi 1638 25 , , , cord-335975-m6lkrehi 1638 26 and and CC cord-335975-m6lkrehi 1638 27 not not RB cord-335975-m6lkrehi 1638 28 explained explain VBN cord-335975-m6lkrehi 1638 29 by by IN cord-335975-m6lkrehi 1638 30 underlying underlie VBG cord-335975-m6lkrehi 1638 31 disease disease NN cord-335975-m6lkrehi 1638 32 . . . cord-335975-m6lkrehi 1639 1 Mortality mortality NN cord-335975-m6lkrehi 1639 2 is be VBZ cord-335975-m6lkrehi 1639 3 reported report VBN cord-335975-m6lkrehi 1639 4 to to TO cord-335975-m6lkrehi 1639 5 be be VB cord-335975-m6lkrehi 1639 6 as as RB cord-335975-m6lkrehi 1639 7 high high JJ cord-335975-m6lkrehi 1639 8 as as IN cord-335975-m6lkrehi 1639 9 13.6 13.6 CD cord-335975-m6lkrehi 1639 10 % % NN cord-335975-m6lkrehi 1639 11 in in IN cord-335975-m6lkrehi 1639 12 cohorts cohort NNS cord-335975-m6lkrehi 1639 13 of of IN cord-335975-m6lkrehi 1639 14 hospitalized hospitalize VBN cord-335975-m6lkrehi 1639 15 patients patient NNS cord-335975-m6lkrehi 1639 16 experiencing experience VBG cord-335975-m6lkrehi 1639 17 IE IE NNP cord-335975-m6lkrehi 1639 18 . . . cord-335975-m6lkrehi 1640 1 Both both DT cord-335975-m6lkrehi 1640 2 length length NN cord-335975-m6lkrehi 1640 3 of of IN cord-335975-m6lkrehi 1640 4 stay stay NN cord-335975-m6lkrehi 1640 5 and and CC cord-335975-m6lkrehi 1640 6 cost cost NN cord-335975-m6lkrehi 1640 7 of of IN cord-335975-m6lkrehi 1640 8 hospitalization hospitalization NN cord-335975-m6lkrehi 1640 9 are be VBP cord-335975-m6lkrehi 1640 10 increased increase VBN cord-335975-m6lkrehi 1640 11 by by IN cord-335975-m6lkrehi 1640 12 IEs IEs NNP cord-335975-m6lkrehi 1640 13 occurrence occurrence NN cord-335975-m6lkrehi 1640 14 . . . cord-335975-m6lkrehi 1641 1 We -PRON- PRP cord-335975-m6lkrehi 1641 2 perform perform VBP cord-335975-m6lkrehi 1641 3 this this DT cord-335975-m6lkrehi 1641 4 study study NN cord-335975-m6lkrehi 1641 5 to to TO cord-335975-m6lkrehi 1641 6 determine determine VB cord-335975-m6lkrehi 1641 7 the the DT cord-335975-m6lkrehi 1641 8 incidence incidence NN cord-335975-m6lkrehi 1641 9 , , , cord-335975-m6lkrehi 1641 10 risk risk NN cord-335975-m6lkrehi 1641 11 factors factor NNS cord-335975-m6lkrehi 1641 12 , , , cord-335975-m6lkrehi 1641 13 and and CC cord-335975-m6lkrehi 1641 14 impact impact NN cord-335975-m6lkrehi 1641 15 on on IN cord-335975-m6lkrehi 1641 16 outcome outcome NN cord-335975-m6lkrehi 1641 17 of of IN cord-335975-m6lkrehi 1641 18 IEs ie NNS cord-335975-m6lkrehi 1641 19 in in IN cord-335975-m6lkrehi 1641 20 intensive intensive JJ cord-335975-m6lkrehi 1641 21 care care NN cord-335975-m6lkrehi 1641 22 unit unit NN cord-335975-m6lkrehi 1641 23 ( ( -LRB- cord-335975-m6lkrehi 1641 24 ICU ICU NNP cord-335975-m6lkrehi 1641 25 ) ) -RRB- cord-335975-m6lkrehi 1641 26 . . . cord-335975-m6lkrehi 1642 1 Patients patient NNS cord-335975-m6lkrehi 1642 2 and and CC cord-335975-m6lkrehi 1642 3 methods method NNS cord-335975-m6lkrehi 1642 4 : : : cord-335975-m6lkrehi 1642 5 All all DT cord-335975-m6lkrehi 1642 6 patients patient NNS cord-335975-m6lkrehi 1642 7 admitted admit VBD cord-335975-m6lkrehi 1642 8 more more JJR cord-335975-m6lkrehi 1642 9 than than IN cord-335975-m6lkrehi 1642 10 24 24 CD cord-335975-m6lkrehi 1642 11 h h NN cord-335975-m6lkrehi 1642 12 to to IN cord-335975-m6lkrehi 1642 13 the the DT cord-335975-m6lkrehi 1642 14 22-bed 22-bed CD cord-335975-m6lkrehi 1642 15 ICU ICU NNP cord-335975-m6lkrehi 1642 16 of of IN cord-335975-m6lkrehi 1642 17 a a DT cord-335975-m6lkrehi 1642 18 teaching teaching NN cord-335975-m6lkrehi 1642 19 hospital hospital NN cord-335975-m6lkrehi 1642 20 were be VBD cord-335975-m6lkrehi 1642 21 prospectively prospectively RB cord-335975-m6lkrehi 1642 22 screened screen VBN cord-335975-m6lkrehi 1642 23 . . . cord-335975-m6lkrehi 1643 1 Patients patient NNS cord-335975-m6lkrehi 1643 2 were be VBD cord-335975-m6lkrehi 1643 3 monitored monitor VBN cord-335975-m6lkrehi 1643 4 daily daily RB cord-335975-m6lkrehi 1643 5 for for IN cord-335975-m6lkrehi 1643 6 adverse adverse JJ cord-335975-m6lkrehi 1643 7 clinical clinical JJ cord-335975-m6lkrehi 1643 8 occurrences occurrence NNS cord-335975-m6lkrehi 1643 9 . . . cord-335975-m6lkrehi 1644 1 Time time NN cord-335975-m6lkrehi 1644 2 and and CC cord-335975-m6lkrehi 1644 3 data datum NNS cord-335975-m6lkrehi 1644 4 about about IN cord-335975-m6lkrehi 1644 5 each each DT cord-335975-m6lkrehi 1644 6 IE IE NNP cord-335975-m6lkrehi 1644 7 were be VBD cord-335975-m6lkrehi 1644 8 collected collect VBN cord-335975-m6lkrehi 1644 9 and and CC cord-335975-m6lkrehi 1644 10 they -PRON- PRP cord-335975-m6lkrehi 1644 11 were be VBD cord-335975-m6lkrehi 1644 12 considered consider VBN cord-335975-m6lkrehi 1644 13 as as RB cord-335975-m6lkrehi 1644 14 preventable preventable JJ cord-335975-m6lkrehi 1644 15 or or CC cord-335975-m6lkrehi 1644 16 life life NN cord-335975-m6lkrehi 1644 17 - - HYPH cord-335975-m6lkrehi 1644 18 threatening threaten VBG cord-335975-m6lkrehi 1644 19 events event NNS cord-335975-m6lkrehi 1644 20 . . . cord-335975-m6lkrehi 1645 1 For for IN cord-335975-m6lkrehi 1645 2 each each DT cord-335975-m6lkrehi 1645 3 patient patient NN cord-335975-m6lkrehi 1645 4 , , , cord-335975-m6lkrehi 1645 5 the the DT cord-335975-m6lkrehi 1645 6 followings following NNS cord-335975-m6lkrehi 1645 7 were be VBD cord-335975-m6lkrehi 1645 8 recorded record VBN cord-335975-m6lkrehi 1645 9 - - HYPH cord-335975-m6lkrehi 1645 10 basic basic JJ cord-335975-m6lkrehi 1645 11 demographic demographic JJ cord-335975-m6lkrehi 1645 12 data datum NNS cord-335975-m6lkrehi 1645 13 , , , cord-335975-m6lkrehi 1645 14 indication indication NN cord-335975-m6lkrehi 1645 15 for for IN cord-335975-m6lkrehi 1645 16 admission admission NN cord-335975-m6lkrehi 1645 17 , , , cord-335975-m6lkrehi 1645 18 severity severity NN cord-335975-m6lkrehi 1645 19 scores score NNS cord-335975-m6lkrehi 1645 20 on on IN cord-335975-m6lkrehi 1645 21 admission admission NN cord-335975-m6lkrehi 1645 22 ( ( -LRB- cord-335975-m6lkrehi 1645 23 SAPSII SAPSII NNP cord-335975-m6lkrehi 1645 24 and and CC cord-335975-m6lkrehi 1645 25 APACHEII APACHEII NNP cord-335975-m6lkrehi 1645 26 ) ) -RRB- cord-335975-m6lkrehi 1645 27 , , , cord-335975-m6lkrehi 1645 28 need need VB cord-335975-m6lkrehi 1645 29 and and CC cord-335975-m6lkrehi 1645 30 duration duration NN cord-335975-m6lkrehi 1645 31 of of IN cord-335975-m6lkrehi 1645 32 mechanical mechanical JJ cord-335975-m6lkrehi 1645 33 ventilation ventilation NN cord-335975-m6lkrehi 1645 34 ( ( -LRB- cord-335975-m6lkrehi 1645 35 MV MV NNP cord-335975-m6lkrehi 1645 36 ) ) -RRB- cord-335975-m6lkrehi 1645 37 , , , cord-335975-m6lkrehi 1645 38 length length NN cord-335975-m6lkrehi 1645 39 of of IN cord-335975-m6lkrehi 1645 40 stay stay NN cord-335975-m6lkrehi 1645 41 ( ( -LRB- cord-335975-m6lkrehi 1645 42 LOS LOS NNP cord-335975-m6lkrehi 1645 43 ) ) -RRB- cord-335975-m6lkrehi 1645 44 in in IN cord-335975-m6lkrehi 1645 45 ICU ICU NNP cord-335975-m6lkrehi 1645 46 , , , cord-335975-m6lkrehi 1645 47 intensive intensive JJ cord-335975-m6lkrehi 1645 48 care care NN cord-335975-m6lkrehi 1645 49 work work NN cord-335975-m6lkrehi 1645 50 load load NN cord-335975-m6lkrehi 1645 51 score score NN cord-335975-m6lkrehi 1645 52 ( ( -LRB- cord-335975-m6lkrehi 1645 53 OMEGA OMEGA NNP cord-335975-m6lkrehi 1645 54 ) ) -RRB- cord-335975-m6lkrehi 1645 55 , , , cord-335975-m6lkrehi 1645 56 global global JJ cord-335975-m6lkrehi 1645 57 mortality mortality NN cord-335975-m6lkrehi 1645 58 and and CC cord-335975-m6lkrehi 1645 59 IEs ie NNS cord-335975-m6lkrehi 1645 60 related relate VBD cord-335975-m6lkrehi 1645 61 mortality mortality NN cord-335975-m6lkrehi 1645 62 . . . cord-335975-m6lkrehi 1646 1 Results result NNS cord-335975-m6lkrehi 1646 2 : : : cord-335975-m6lkrehi 1647 1 During during IN cord-335975-m6lkrehi 1647 2 the the DT cord-335975-m6lkrehi 1647 3 6 6 CD cord-335975-m6lkrehi 1647 4 months month NNS cord-335975-m6lkrehi 1647 5 period period NN cord-335975-m6lkrehi 1647 6 , , , cord-335975-m6lkrehi 1647 7 167 167 CD cord-335975-m6lkrehi 1647 8 patients patient NNS cord-335975-m6lkrehi 1647 9 were be VBD cord-335975-m6lkrehi 1647 10 included include VBN cord-335975-m6lkrehi 1647 11 and and CC cord-335975-m6lkrehi 1647 12 65 65 CD cord-335975-m6lkrehi 1647 13 ( ( -LRB- cord-335975-m6lkrehi 1647 14 38.9 38.9 CD cord-335975-m6lkrehi 1647 15 % % NN cord-335975-m6lkrehi 1647 16 ) ) -RRB- cord-335975-m6lkrehi 1647 17 were be VBD cord-335975-m6lkrehi 1647 18 judged judge VBN cord-335975-m6lkrehi 1647 19 to to TO cord-335975-m6lkrehi 1647 20 have have VB cord-335975-m6lkrehi 1647 21 developed develop VBN cord-335975-m6lkrehi 1647 22 an an DT cord-335975-m6lkrehi 1647 23 IE IE NNP cord-335975-m6lkrehi 1647 24 while while IN cord-335975-m6lkrehi 1647 25 hospitalized hospitalize VBN cord-335975-m6lkrehi 1647 26 . . . cord-335975-m6lkrehi 1648 1 We -PRON- PRP cord-335975-m6lkrehi 1648 2 recorded record VBD cord-335975-m6lkrehi 1648 3 282 282 CD cord-335975-m6lkrehi 1648 4 IEs ie NNS cord-335975-m6lkrehi 1648 5 over over IN cord-335975-m6lkrehi 1648 6 2004 2004 CD cord-335975-m6lkrehi 1648 7 days day NNS cord-335975-m6lkrehi 1648 8 in in IN cord-335975-m6lkrehi 1648 9 ICU ICU NNP cord-335975-m6lkrehi 1648 10 so so IN cord-335975-m6lkrehi 1648 11 a a DT cord-335975-m6lkrehi 1648 12 density density NN cord-335975-m6lkrehi 1648 13 incidence incidence NN cord-335975-m6lkrehi 1648 14 of of IN cord-335975-m6lkrehi 1648 15 14 14 CD cord-335975-m6lkrehi 1648 16 IE ie NN cord-335975-m6lkrehi 1648 17 for for IN cord-335975-m6lkrehi 1648 18 100 100 CD cord-335975-m6lkrehi 1648 19 patient patient NN cord-335975-m6lkrehi 1648 20 - - HYPH cord-335975-m6lkrehi 1648 21 day day NN cord-335975-m6lkrehi 1648 22 . . . cord-335975-m6lkrehi 1649 1 IEs ie NNS cord-335975-m6lkrehi 1649 2 were be VBD cord-335975-m6lkrehi 1649 3 considered consider VBN cord-335975-m6lkrehi 1649 4 preventable preventable JJ cord-335975-m6lkrehi 1649 5 in in IN cord-335975-m6lkrehi 1649 6 34 34 CD cord-335975-m6lkrehi 1649 7 % % NN cord-335975-m6lkrehi 1649 8 of of IN cord-335975-m6lkrehi 1649 9 cases case NNS cord-335975-m6lkrehi 1649 10 and and CC cord-335975-m6lkrehi 1649 11 life life NN cord-335975-m6lkrehi 1649 12 - - HYPH cord-335975-m6lkrehi 1649 13 threatening threaten VBG cord-335975-m6lkrehi 1649 14 in in IN cord-335975-m6lkrehi 1649 15 22 22 CD cord-335975-m6lkrehi 1649 16 % % NN cord-335975-m6lkrehi 1649 17 of of IN cord-335975-m6lkrehi 1649 18 cases case NNS cord-335975-m6lkrehi 1649 19 . . . cord-335975-m6lkrehi 1650 1 IEs ie NNS cord-335975-m6lkrehi 1650 2 occurred occur VBD cord-335975-m6lkrehi 1650 3 in in IN cord-335975-m6lkrehi 1650 4 a a DT cord-335975-m6lkrehi 1650 5 mean mean JJ cord-335975-m6lkrehi 1650 6 delay delay NN cord-335975-m6lkrehi 1650 7 of of IN cord-335975-m6lkrehi 1650 8 6 6 CD cord-335975-m6lkrehi 1650 9 ± ± CD cord-335975-m6lkrehi 1650 10 6 6 CD cord-335975-m6lkrehi 1650 11 days day NNS cord-335975-m6lkrehi 1650 12 . . . cord-335975-m6lkrehi 1651 1 Global global JJ cord-335975-m6lkrehi 1651 2 mortality mortality NN cord-335975-m6lkrehi 1651 3 rate rate NN cord-335975-m6lkrehi 1651 4 was be VBD cord-335975-m6lkrehi 1651 5 36.5 36.5 CD cord-335975-m6lkrehi 1651 6 % % NN cord-335975-m6lkrehi 1651 7 and and CC cord-335975-m6lkrehi 1651 8 IEs ie NNS cord-335975-m6lkrehi 1651 9 related relate VBD cord-335975-m6lkrehi 1651 10 mortality mortality NN cord-335975-m6lkrehi 1651 11 rate rate NN cord-335975-m6lkrehi 1651 12 was be VBD cord-335975-m6lkrehi 1651 13 13.7 13.7 CD cord-335975-m6lkrehi 1651 14 % % NN cord-335975-m6lkrehi 1651 15 . . . cord-335975-m6lkrehi 1652 1 Patients patient NNS cord-335975-m6lkrehi 1652 2 with with IN cord-335975-m6lkrehi 1652 3 IEs ie NNS cord-335975-m6lkrehi 1652 4 were be VBD cord-335975-m6lkrehi 1652 5 significantly significantly RB cord-335975-m6lkrehi 1652 6 severe severe JJ cord-335975-m6lkrehi 1652 7 on on IN cord-335975-m6lkrehi 1652 8 admission admission NN cord-335975-m6lkrehi 1652 9 , , , cord-335975-m6lkrehi 1652 10 with with IN cord-335975-m6lkrehi 1652 11 a a DT cord-335975-m6lkrehi 1652 12 longer long JJR cord-335975-m6lkrehi 1652 13 duration duration NN cord-335975-m6lkrehi 1652 14 of of IN cord-335975-m6lkrehi 1652 15 MV MV NNP cord-335975-m6lkrehi 1652 16 and and CC cord-335975-m6lkrehi 1652 17 LOS LOS NNP cord-335975-m6lkrehi 1652 18 in in IN cord-335975-m6lkrehi 1652 19 ICU ICU NNP cord-335975-m6lkrehi 1652 20 . . . cord-335975-m6lkrehi 1653 1 OMEGA omega NN cord-335975-m6lkrehi 1653 2 score score NN cord-335975-m6lkrehi 1653 3 was be VBD cord-335975-m6lkrehi 1653 4 significantly significantly RB cord-335975-m6lkrehi 1653 5 higher high JJR cord-335975-m6lkrehi 1653 6 . . . cord-335975-m6lkrehi 1654 1 Multivariate multivariate JJ cord-335975-m6lkrehi 1654 2 analysis analysis NN cord-335975-m6lkrehi 1654 3 showed show VBD cord-335975-m6lkrehi 1654 4 that that IN cord-335975-m6lkrehi 1654 5 OMEGA omega NN cord-335975-m6lkrehi 1654 6 score score NN cord-335975-m6lkrehi 1654 7 was be VBD cord-335975-m6lkrehi 1654 8 the the DT cord-335975-m6lkrehi 1654 9 independent independent JJ cord-335975-m6lkrehi 1654 10 risk risk NN cord-335975-m6lkrehi 1654 11 factor factor NN cord-335975-m6lkrehi 1654 12 of of IN cord-335975-m6lkrehi 1654 13 IEs ie NNS cord-335975-m6lkrehi 1654 14 occurrence occurrence NN cord-335975-m6lkrehi 1654 15 ( ( -LRB- cord-335975-m6lkrehi 1654 16 OR or CC cord-335975-m6lkrehi 1654 17 1.031 1.031 CD cord-335975-m6lkrehi 1654 18 IC IC NNP cord-335975-m6lkrehi 1654 19 95 95 CD cord-335975-m6lkrehi 1654 20 % % NN cord-335975-m6lkrehi 1654 21 [ [ -LRB- cord-335975-m6lkrehi 1654 22 1.015 1.015 CD cord-335975-m6lkrehi 1654 23 - - SYM cord-335975-m6lkrehi 1654 24 1.047 1.047 CD cord-335975-m6lkrehi 1654 25 ] ] -RRB- cord-335975-m6lkrehi 1654 26 , , , cord-335975-m6lkrehi 1654 27 p p NN cord-335975-m6lkrehi 1654 28 < < XX cord-335975-m6lkrehi 1654 29 10 10 CD cord-335975-m6lkrehi 1654 30 -3 -3 NNP cord-335975-m6lkrehi 1654 31 ) ) -RRB- cord-335975-m6lkrehi 1654 32 . . . cord-335975-m6lkrehi 1655 1 Dead dead JJ cord-335975-m6lkrehi 1655 2 patients patient NNS cord-335975-m6lkrehi 1655 3 were be VBD cord-335975-m6lkrehi 1655 4 significantly significantly RB cord-335975-m6lkrehi 1655 5 severe severe JJ cord-335975-m6lkrehi 1655 6 on on IN cord-335975-m6lkrehi 1655 7 admission admission NN cord-335975-m6lkrehi 1655 8 and and CC cord-335975-m6lkrehi 1655 9 experienced experience VBD cord-335975-m6lkrehi 1655 10 more more JJR cord-335975-m6lkrehi 1655 11 IEs ie NNS cord-335975-m6lkrehi 1655 12 than than IN cord-335975-m6lkrehi 1655 13 survivors survivor NNS cord-335975-m6lkrehi 1655 14 . . . cord-335975-m6lkrehi 1656 1 OMEGA omega NN cord-335975-m6lkrehi 1656 2 score score NN cord-335975-m6lkrehi 1656 3 , , , cord-335975-m6lkrehi 1656 4 duration duration NN cord-335975-m6lkrehi 1656 5 of of IN cord-335975-m6lkrehi 1656 6 MV MV NNP cord-335975-m6lkrehi 1656 7 and and CC cord-335975-m6lkrehi 1656 8 LOS LOS NNP cord-335975-m6lkrehi 1656 9 were be VBD cord-335975-m6lkrehi 1656 10 significantly significantly RB cord-335975-m6lkrehi 1656 11 higher high JJR cord-335975-m6lkrehi 1656 12 . . . cord-335975-m6lkrehi 1657 1 In in IN cord-335975-m6lkrehi 1657 2 multivariate multivariate JJ cord-335975-m6lkrehi 1657 3 analysis analysis NN cord-335975-m6lkrehi 1657 4 , , , cord-335975-m6lkrehi 1657 5 IEs ie NNS cord-335975-m6lkrehi 1657 6 and and CC cord-335975-m6lkrehi 1657 7 life life NN cord-335975-m6lkrehi 1657 8 - - HYPH cord-335975-m6lkrehi 1657 9 threatening threaten VBG cord-335975-m6lkrehi 1657 10 IEs ie NNS cord-335975-m6lkrehi 1657 11 were be VBD cord-335975-m6lkrehi 1657 12 independent independent JJ cord-335975-m6lkrehi 1657 13 factors factor NNS cord-335975-m6lkrehi 1657 14 of of IN cord-335975-m6lkrehi 1657 15 mortality mortality NN cord-335975-m6lkrehi 1657 16 ( ( -LRB- cord-335975-m6lkrehi 1657 17 OR or CC cord-335975-m6lkrehi 1657 18 6.171 6.171 CD cord-335975-m6lkrehi 1657 19 IC IC NNP cord-335975-m6lkrehi 1657 20 95 95 CD cord-335975-m6lkrehi 1657 21 % % NN cord-335975-m6lkrehi 1657 22 [ [ -LRB- cord-335975-m6lkrehi 1657 23 3.087 3.087 CD cord-335975-m6lkrehi 1657 24 - - HYPH cord-335975-m6lkrehi 1657 25 12.339 12.339 CD cord-335975-m6lkrehi 1657 26 ] ] -RRB- cord-335975-m6lkrehi 1657 27 , , , cord-335975-m6lkrehi 1657 28 p p NN cord-335975-m6lkrehi 1657 29 < < XX cord-335975-m6lkrehi 1657 30 10 10 CD cord-335975-m6lkrehi 1657 31 -3 -3 NNP cord-335975-m6lkrehi 1657 32 and and CC cord-335975-m6lkrehi 1658 1 OR or CC cord-335975-m6lkrehi 1658 2 21.482 21.482 CD cord-335975-m6lkrehi 1658 3 IC IC NNP cord-335975-m6lkrehi 1658 4 95 95 CD cord-335975-m6lkrehi 1658 5 % % NN cord-335975-m6lkrehi 1658 6 [ [ -LRB- cord-335975-m6lkrehi 1658 7 5.077 5.077 CD cord-335975-m6lkrehi 1658 8 - - HYPH cord-335975-m6lkrehi 1658 9 90.889 90.889 CD cord-335975-m6lkrehi 1658 10 ] ] -RRB- cord-335975-m6lkrehi 1659 1 , , , cord-335975-m6lkrehi 1659 2 p p NN cord-335975-m6lkrehi 1659 3 < < XX cord-335975-m6lkrehi 1659 4 10 10 CD cord-335975-m6lkrehi 1659 5 -3 -3 NNP cord-335975-m6lkrehi 1659 6 respectively respectively RB cord-335975-m6lkrehi 1659 7 ) ) -RRB- cord-335975-m6lkrehi 1659 8 . . . cord-335975-m6lkrehi 1660 1 Conclusion conclusion NN cord-335975-m6lkrehi 1660 2 : : : cord-335975-m6lkrehi 1660 3 IEs IEs NNP cord-335975-m6lkrehi 1660 4 in in IN cord-335975-m6lkrehi 1660 5 ICU ICU NNP cord-335975-m6lkrehi 1660 6 are be VBP cord-335975-m6lkrehi 1660 7 common common JJ cord-335975-m6lkrehi 1660 8 and and CC cord-335975-m6lkrehi 1660 9 frequent frequent JJ cord-335975-m6lkrehi 1660 10 but but CC cord-335975-m6lkrehi 1660 11 one one CD cord-335975-m6lkrehi 1660 12 - - HYPH cord-335975-m6lkrehi 1660 13 third third NN cord-335975-m6lkrehi 1660 14 is be VBZ cord-335975-m6lkrehi 1660 15 preventable preventable JJ cord-335975-m6lkrehi 1660 16 . . . cord-335975-m6lkrehi 1661 1 Work work NN cord-335975-m6lkrehi 1661 2 load load VB cord-335975-m6lkrehi 1661 3 ICU ICU NNP cord-335975-m6lkrehi 1661 4 score score NN cord-335975-m6lkrehi 1661 5 is be VBZ cord-335975-m6lkrehi 1661 6 the the DT cord-335975-m6lkrehi 1661 7 independent independent JJ cord-335975-m6lkrehi 1661 8 risk risk NN cord-335975-m6lkrehi 1661 9 factor factor NN cord-335975-m6lkrehi 1661 10 of of IN cord-335975-m6lkrehi 1661 11 their -PRON- PRP$ cord-335975-m6lkrehi 1661 12 occurrence occurrence NN cord-335975-m6lkrehi 1661 13 . . . cord-335975-m6lkrehi 1662 1 IEs IEs NNP cord-335975-m6lkrehi 1662 2 impact impact NN cord-335975-m6lkrehi 1662 3 largely largely RB cord-335975-m6lkrehi 1662 4 the the DT cord-335975-m6lkrehi 1662 5 outcome outcome NN cord-335975-m6lkrehi 1662 6 especially especially RB cord-335975-m6lkrehi 1662 7 the the DT cord-335975-m6lkrehi 1662 8 lifethreatening lifethreatening JJ cord-335975-m6lkrehi 1662 9 ones one NNS cord-335975-m6lkrehi 1662 10 . . . cord-335975-m6lkrehi 1663 1 Efforts effort NNS cord-335975-m6lkrehi 1663 2 must must MD cord-335975-m6lkrehi 1663 3 be be VB cord-335975-m6lkrehi 1663 4 focused focus VBN cord-335975-m6lkrehi 1663 5 on on IN cord-335975-m6lkrehi 1663 6 preventing prevent VBG cord-335975-m6lkrehi 1663 7 programs program NNS cord-335975-m6lkrehi 1663 8 to to TO cord-335975-m6lkrehi 1663 9 reduce reduce VB cord-335975-m6lkrehi 1663 10 IEs ie NNS cord-335975-m6lkrehi 1663 11 and and CC cord-335975-m6lkrehi 1663 12 improve improve VB cord-335975-m6lkrehi 1663 13 the the DT cord-335975-m6lkrehi 1663 14 outcome outcome NN cord-335975-m6lkrehi 1663 15 . . . cord-335975-m6lkrehi 1664 1 Introduction introduction NN cord-335975-m6lkrehi 1664 2 : : : cord-335975-m6lkrehi 1665 1 Based base VBN cord-335975-m6lkrehi 1665 2 on on IN cord-335975-m6lkrehi 1665 3 the the DT cord-335975-m6lkrehi 1665 4 recent recent JJ cord-335975-m6lkrehi 1665 5 SEPSIS-3 sepsis-3 JJ cord-335975-m6lkrehi 1665 6 definitions definition NNS cord-335975-m6lkrehi 1665 7 , , , cord-335975-m6lkrehi 1665 8 septic septic JJ cord-335975-m6lkrehi 1665 9 shock shock NN cord-335975-m6lkrehi 1665 10 is be VBZ cord-335975-m6lkrehi 1665 11 defined define VBN cord-335975-m6lkrehi 1665 12 by by IN cord-335975-m6lkrehi 1665 13 the the DT cord-335975-m6lkrehi 1665 14 combination combination NN cord-335975-m6lkrehi 1665 15 of of IN cord-335975-m6lkrehi 1665 16 vasopressor vasopressor NN cord-335975-m6lkrehi 1665 17 requirement requirement NN cord-335975-m6lkrehi 1665 18 and and CC cord-335975-m6lkrehi 1665 19 serum serum NN cord-335975-m6lkrehi 1665 20 lactate lactate NN cord-335975-m6lkrehi 1665 21 level level NN cord-335975-m6lkrehi 1665 22 > > XX cord-335975-m6lkrehi 1665 23 2 2 CD cord-335975-m6lkrehi 1665 24 mmol mmol NNP cord-335975-m6lkrehi 1665 25 / / SYM cord-335975-m6lkrehi 1665 26 L. L. NNP cord-335975-m6lkrehi 1666 1 However however RB cord-335975-m6lkrehi 1666 2 hyperlactatemia hyperlactatemia NN cord-335975-m6lkrehi 1666 3 and and CC cord-335975-m6lkrehi 1666 4 lactate lactate NN cord-335975-m6lkrehi 1666 5 kinetics kinetic NNS cord-335975-m6lkrehi 1666 6 may may MD cord-335975-m6lkrehi 1666 7 result result VB cord-335975-m6lkrehi 1666 8 from from IN cord-335975-m6lkrehi 1666 9 both both CC cord-335975-m6lkrehi 1666 10 increased increase VBN cord-335975-m6lkrehi 1666 11 production production NN cord-335975-m6lkrehi 1666 12 and and CC cord-335975-m6lkrehi 1666 13 impaired impaired JJ cord-335975-m6lkrehi 1666 14 clearance clearance NN cord-335975-m6lkrehi 1666 15 in in IN cord-335975-m6lkrehi 1666 16 the the DT cord-335975-m6lkrehi 1666 17 critically critically RB cord-335975-m6lkrehi 1666 18 ill ill JJ cord-335975-m6lkrehi 1666 19 , , , cord-335975-m6lkrehi 1666 20 and and CC cord-335975-m6lkrehi 1666 21 may may MD cord-335975-m6lkrehi 1666 22 therefore therefore RB cord-335975-m6lkrehi 1666 23 not not RB cord-335975-m6lkrehi 1666 24 only only RB cord-335975-m6lkrehi 1666 25 rely rely VB cord-335975-m6lkrehi 1666 26 on on IN cord-335975-m6lkrehi 1666 27 the the DT cord-335975-m6lkrehi 1666 28 severity severity NN cord-335975-m6lkrehi 1666 29 of of IN cord-335975-m6lkrehi 1666 30 circulatory circulatory JJ cord-335975-m6lkrehi 1666 31 failure failure NN cord-335975-m6lkrehi 1666 32 . . . cord-335975-m6lkrehi 1667 1 We -PRON- PRP cord-335975-m6lkrehi 1667 2 herein herein RB cord-335975-m6lkrehi 1667 3 addressed address VBD cord-335975-m6lkrehi 1667 4 the the DT cord-335975-m6lkrehi 1667 5 determinants determinant NNS cord-335975-m6lkrehi 1667 6 of of IN cord-335975-m6lkrehi 1667 7 hyperlactatemia hyperlactatemia NN cord-335975-m6lkrehi 1667 8 ( ( -LRB- cord-335975-m6lkrehi 1667 9 > > NFP cord-335975-m6lkrehi 1667 10 2 2 CD cord-335975-m6lkrehi 1667 11 mmol mmol NNP cord-335975-m6lkrehi 1667 12 / / SYM cord-335975-m6lkrehi 1667 13 L L NNP cord-335975-m6lkrehi 1667 14 ) ) -RRB- cord-335975-m6lkrehi 1667 15 and and CC cord-335975-m6lkrehi 1667 16 the the DT cord-335975-m6lkrehi 1667 17 factors factor NNS cord-335975-m6lkrehi 1667 18 likely likely JJ cord-335975-m6lkrehi 1667 19 to to TO cord-335975-m6lkrehi 1667 20 impact impact VB cord-335975-m6lkrehi 1667 21 on on IN cord-335975-m6lkrehi 1667 22 early early JJ cord-335975-m6lkrehi 1667 23 lactate lactate NN cord-335975-m6lkrehi 1667 24 clearance clearance NN cord-335975-m6lkrehi 1667 25 in in IN cord-335975-m6lkrehi 1667 26 septic septic JJ cord-335975-m6lkrehi 1667 27 shock shock NN cord-335975-m6lkrehi 1667 28 . . . cord-335975-m6lkrehi 1668 1 Patients patient NNS cord-335975-m6lkrehi 1668 2 and and CC cord-335975-m6lkrehi 1668 3 methods method NNS cord-335975-m6lkrehi 1669 1 : : : cord-335975-m6lkrehi 1669 2 This this DT cord-335975-m6lkrehi 1669 3 was be VBD cord-335975-m6lkrehi 1669 4 a a DT cord-335975-m6lkrehi 1669 5 9-year 9-year CD cord-335975-m6lkrehi 1669 6 ( ( -LRB- cord-335975-m6lkrehi 1669 7 2008 2008 CD cord-335975-m6lkrehi 1669 8 - - SYM cord-335975-m6lkrehi 1669 9 2016 2016 CD cord-335975-m6lkrehi 1669 10 ) ) -RRB- cord-335975-m6lkrehi 1669 11 monocentric monocentric JJ cord-335975-m6lkrehi 1669 12 retrospective retrospective JJ cord-335975-m6lkrehi 1669 13 study study NN cord-335975-m6lkrehi 1669 14 . . . cord-335975-m6lkrehi 1670 1 All all DT cord-335975-m6lkrehi 1670 2 adult adult NN cord-335975-m6lkrehi 1670 3 patients patient NNS cord-335975-m6lkrehi 1670 4 diagnosed diagnose VBN cord-335975-m6lkrehi 1670 5 for for IN cord-335975-m6lkrehi 1670 6 septic septic JJ cord-335975-m6lkrehi 1670 7 shock shock NN cord-335975-m6lkrehi 1670 8 within within IN cord-335975-m6lkrehi 1670 9 the the DT cord-335975-m6lkrehi 1670 10 first first JJ cord-335975-m6lkrehi 1670 11 48 48 CD cord-335975-m6lkrehi 1670 12 h h NN cord-335975-m6lkrehi 1670 13 were be VBD cord-335975-m6lkrehi 1670 14 included include VBN cord-335975-m6lkrehi 1670 15 . . . cord-335975-m6lkrehi 1671 1 Septic septic JJ cord-335975-m6lkrehi 1671 2 shock shock NN cord-335975-m6lkrehi 1671 3 was be VBD cord-335975-m6lkrehi 1671 4 defined define VBN cord-335975-m6lkrehi 1671 5 as as IN cord-335975-m6lkrehi 1671 6 a a DT cord-335975-m6lkrehi 1671 7 microbiologically microbiologically NN cord-335975-m6lkrehi 1671 8 proven prove VBN cord-335975-m6lkrehi 1671 9 or or CC cord-335975-m6lkrehi 1671 10 clinically clinically RB cord-335975-m6lkrehi 1671 11 suspected suspect VBN cord-335975-m6lkrehi 1671 12 infection infection NN cord-335975-m6lkrehi 1671 13 , , , cord-335975-m6lkrehi 1671 14 associated associate VBN cord-335975-m6lkrehi 1671 15 with with IN cord-335975-m6lkrehi 1671 16 acute acute JJ cord-335975-m6lkrehi 1671 17 circulatory circulatory JJ cord-335975-m6lkrehi 1671 18 failure failure NN cord-335975-m6lkrehi 1671 19 requiring require VBG cord-335975-m6lkrehi 1671 20 vasopressors vasopressor NNS cord-335975-m6lkrehi 1671 21 . . . cord-335975-m6lkrehi 1672 1 The the DT cord-335975-m6lkrehi 1672 2 first first JJ cord-335975-m6lkrehi 1672 3 lactate lactate NN cord-335975-m6lkrehi 1672 4 value value NN cord-335975-m6lkrehi 1672 5 ( ( -LRB- cord-335975-m6lkrehi 1672 6 L1 L1 NNP cord-335975-m6lkrehi 1672 7 ) ) -RRB- cord-335975-m6lkrehi 1672 8 was be VBD cord-335975-m6lkrehi 1672 9 measured measure VBN cord-335975-m6lkrehi 1672 10 at at IN cord-335975-m6lkrehi 1672 11 the the DT cord-335975-m6lkrehi 1672 12 time time NN cord-335975-m6lkrehi 1672 13 of of IN cord-335975-m6lkrehi 1672 14 ICU ICU NNP cord-335975-m6lkrehi 1672 15 admission admission NN cord-335975-m6lkrehi 1672 16 . . . cord-335975-m6lkrehi 1673 1 Hyperlactatemia Hyperlactatemia NNP cord-335975-m6lkrehi 1673 2 was be VBD cord-335975-m6lkrehi 1673 3 defined define VBN cord-335975-m6lkrehi 1673 4 as as IN cord-335975-m6lkrehi 1673 5 a a DT cord-335975-m6lkrehi 1673 6 first first JJ cord-335975-m6lkrehi 1673 7 lactate lactate NN cord-335975-m6lkrehi 1673 8 level level NN cord-335975-m6lkrehi 1673 9 > > XX cord-335975-m6lkrehi 1673 10 2 2 CD cord-335975-m6lkrehi 1673 11 mmol mmol NNP cord-335975-m6lkrehi 1673 12 / / SYM cord-335975-m6lkrehi 1673 13 L. L. NNP cord-335975-m6lkrehi 1674 1 The the DT cord-335975-m6lkrehi 1674 2 second second JJ cord-335975-m6lkrehi 1674 3 value value NN cord-335975-m6lkrehi 1674 4 ( ( -LRB- cord-335975-m6lkrehi 1674 5 L2 L2 NNP cord-335975-m6lkrehi 1674 6 ) ) -RRB- cord-335975-m6lkrehi 1674 7 was be VBD cord-335975-m6lkrehi 1674 8 measured measure VBN cord-335975-m6lkrehi 1674 9 within within IN cord-335975-m6lkrehi 1674 10 12 12 CD cord-335975-m6lkrehi 1674 11 h h NN cord-335975-m6lkrehi 1674 12 following follow VBG cord-335975-m6lkrehi 1674 13 the the DT cord-335975-m6lkrehi 1674 14 first first JJ cord-335975-m6lkrehi 1674 15 measurement measurement NN cord-335975-m6lkrehi 1674 16 . . . cord-335975-m6lkrehi 1675 1 Lactate lactate NN cord-335975-m6lkrehi 1675 2 clearance clearance NN cord-335975-m6lkrehi 1675 3 was be VBD cord-335975-m6lkrehi 1675 4 calculated calculate VBN cord-335975-m6lkrehi 1675 5 as as IN cord-335975-m6lkrehi 1675 6 ( ( -LRB- cord-335975-m6lkrehi 1675 7 L1-L2 L1-L2 NNP cord-335975-m6lkrehi 1675 8 ) ) -RRB- cord-335975-m6lkrehi 1675 9 L1 L1 NNP cord-335975-m6lkrehi 1675 10 time time NN cord-335975-m6lkrehi 1675 11 between between IN cord-335975-m6lkrehi 1675 12 L1 L1 NNP cord-335975-m6lkrehi 1675 13 and and CC cord-335975-m6lkrehi 1675 14 L2 L2 NNP cord-335975-m6lkrehi 1675 15 measurements measurement NNS cord-335975-m6lkrehi 1675 16 ) ) -RRB- cord-335975-m6lkrehi 1675 17 and and CC cord-335975-m6lkrehi 1675 18 expressed express VBN cord-335975-m6lkrehi 1675 19 in in IN cord-335975-m6lkrehi 1675 20 mmol mmol JJ cord-335975-m6lkrehi 1675 21 hour hour NN cord-335975-m6lkrehi 1675 22 . . . cord-335975-m6lkrehi 1676 1 Parameters parameter NNS cord-335975-m6lkrehi 1676 2 associated associate VBN cord-335975-m6lkrehi 1676 3 with with IN cord-335975-m6lkrehi 1676 4 initial initial JJ cord-335975-m6lkrehi 1676 5 hyperlactatemia hyperlactatemia NN cord-335975-m6lkrehi 1676 6 and and CC cord-335975-m6lkrehi 1676 7 lactate lactate NN cord-335975-m6lkrehi 1676 8 clearance clearance NN cord-335975-m6lkrehi 1676 9 were be VBD cord-335975-m6lkrehi 1676 10 investigated investigate VBN cord-335975-m6lkrehi 1676 11 using use VBG cord-335975-m6lkrehi 1676 12 multivariate multivariate JJ cord-335975-m6lkrehi 1676 13 logistic logistic JJ cord-335975-m6lkrehi 1676 14 regression regression NN cord-335975-m6lkrehi 1676 15 analysis analysis NN cord-335975-m6lkrehi 1676 16 . . . cord-335975-m6lkrehi 1677 1 Introduction introduction NN cord-335975-m6lkrehi 1677 2 : : : cord-335975-m6lkrehi 1677 3 Cardiac cardiac JJ cord-335975-m6lkrehi 1677 4 surgery surgery NN cord-335975-m6lkrehi 1677 5 with with IN cord-335975-m6lkrehi 1677 6 cardiopulmonary cardiopulmonary JJ cord-335975-m6lkrehi 1677 7 bypass bypass NN cord-335975-m6lkrehi 1678 1 ( ( -LRB- cord-335975-m6lkrehi 1678 2 CPB CPB NNP cord-335975-m6lkrehi 1678 3 ) ) -RRB- cord-335975-m6lkrehi 1678 4 induces induce VBZ cord-335975-m6lkrehi 1678 5 immunosuppression immunosuppression NN cord-335975-m6lkrehi 1678 6 which which WDT cord-335975-m6lkrehi 1678 7 has have VBZ cord-335975-m6lkrehi 1678 8 considerable considerable JJ cord-335975-m6lkrehi 1678 9 implications implication NNS cord-335975-m6lkrehi 1678 10 for for IN cord-335975-m6lkrehi 1678 11 patients patient NNS cord-335975-m6lkrehi 1678 12 . . . cord-335975-m6lkrehi 1679 1 CPB CPB NNP cord-335975-m6lkrehi 1679 2 induces induce VBZ cord-335975-m6lkrehi 1679 3 a a DT cord-335975-m6lkrehi 1679 4 significant significant JJ cord-335975-m6lkrehi 1679 5 increase increase NN cord-335975-m6lkrehi 1679 6 in in IN cord-335975-m6lkrehi 1679 7 circulating circulate VBG cord-335975-m6lkrehi 1679 8 neutrophils neutrophil NNS cord-335975-m6lkrehi 1679 9 . . . cord-335975-m6lkrehi 1680 1 Neutrophil Neutrophil NNP cord-335975-m6lkrehi 1680 2 activation activation NN cord-335975-m6lkrehi 1680 3 , , , cord-335975-m6lkrehi 1680 4 associated associate VBN cord-335975-m6lkrehi 1680 5 with with IN cord-335975-m6lkrehi 1680 6 production production NN cord-335975-m6lkrehi 1680 7 of of IN cord-335975-m6lkrehi 1680 8 antibacterial antibacterial JJ cord-335975-m6lkrehi 1680 9 peptides peptide NNS cord-335975-m6lkrehi 1680 10 , , , cord-335975-m6lkrehi 1680 11 reactive reactive JJ cord-335975-m6lkrehi 1680 12 oxygen oxygen NN cord-335975-m6lkrehi 1680 13 species specie NNS cord-335975-m6lkrehi 1680 14 ( ( -LRB- cord-335975-m6lkrehi 1680 15 ROS ROS NNP cord-335975-m6lkrehi 1680 16 ) ) -RRB- cord-335975-m6lkrehi 1680 17 , , , cord-335975-m6lkrehi 1680 18 cytokines cytokine NNS cord-335975-m6lkrehi 1680 19 , , , cord-335975-m6lkrehi 1680 20 and and CC cord-335975-m6lkrehi 1680 21 other other JJ cord-335975-m6lkrehi 1680 22 inflammatory inflammatory JJ cord-335975-m6lkrehi 1680 23 mediators mediator NNS cord-335975-m6lkrehi 1680 24 , , , cord-335975-m6lkrehi 1680 25 as as RB cord-335975-m6lkrehi 1680 26 well well RB cord-335975-m6lkrehi 1680 27 as as IN cord-335975-m6lkrehi 1680 28 release release NN cord-335975-m6lkrehi 1680 29 of of IN cord-335975-m6lkrehi 1680 30 DNA dna NN cord-335975-m6lkrehi 1680 31 into into IN cord-335975-m6lkrehi 1680 32 the the DT cord-335975-m6lkrehi 1680 33 extracellular extracellular JJ cord-335975-m6lkrehi 1680 34 milieu milieu NN cord-335975-m6lkrehi 1680 35 ( ( -LRB- cord-335975-m6lkrehi 1680 36 Neutrophil Neutrophil NNP cord-335975-m6lkrehi 1680 37 extracellular extracellular JJ cord-335975-m6lkrehi 1680 38 traps trap NNS cord-335975-m6lkrehi 1680 39 ( ( -LRB- cord-335975-m6lkrehi 1680 40 NETs NETs NNP cord-335975-m6lkrehi 1680 41 ) ) -RRB- cord-335975-m6lkrehi 1680 42 ) ) -RRB- cord-335975-m6lkrehi 1680 43 , , , cord-335975-m6lkrehi 1680 44 plays play VBZ cord-335975-m6lkrehi 1680 45 a a DT cord-335975-m6lkrehi 1680 46 central central JJ cord-335975-m6lkrehi 1680 47 role role NN cord-335975-m6lkrehi 1680 48 in in IN cord-335975-m6lkrehi 1680 49 innate innate JJ cord-335975-m6lkrehi 1680 50 host host NN cord-335975-m6lkrehi 1680 51 defense defense NN cord-335975-m6lkrehi 1680 52 and and CC cord-335975-m6lkrehi 1680 53 modulation modulation NN cord-335975-m6lkrehi 1680 54 of of IN cord-335975-m6lkrehi 1680 55 inflammation inflammation NN cord-335975-m6lkrehi 1680 56 . . . cord-335975-m6lkrehi 1681 1 However however RB cord-335975-m6lkrehi 1681 2 , , , cord-335975-m6lkrehi 1681 3 it -PRON- PRP cord-335975-m6lkrehi 1681 4 has have VBZ cord-335975-m6lkrehi 1681 5 been be VBN cord-335975-m6lkrehi 1681 6 shown show VBN cord-335975-m6lkrehi 1681 7 that that IN cord-335975-m6lkrehi 1681 8 , , , cord-335975-m6lkrehi 1681 9 in in IN cord-335975-m6lkrehi 1681 10 septic septic JJ cord-335975-m6lkrehi 1681 11 shock shock NN cord-335975-m6lkrehi 1681 12 or or CC cord-335975-m6lkrehi 1681 13 systemic systemic JJ cord-335975-m6lkrehi 1681 14 inflammation inflammation NN cord-335975-m6lkrehi 1681 15 as as IN cord-335975-m6lkrehi 1681 16 major major JJ cord-335975-m6lkrehi 1681 17 surgery surgery NN cord-335975-m6lkrehi 1681 18 , , , cord-335975-m6lkrehi 1681 19 immature immature JJ cord-335975-m6lkrehi 1681 20 circulating circulate VBG cord-335975-m6lkrehi 1681 21 neutrophils neutrophil NNS cord-335975-m6lkrehi 1681 22 can can MD cord-335975-m6lkrehi 1681 23 induce induce VB cord-335975-m6lkrehi 1681 24 immunosuppression immunosuppression NN cord-335975-m6lkrehi 1681 25 and and CC cord-335975-m6lkrehi 1681 26 increase increase VB cord-335975-m6lkrehi 1681 27 the the DT cord-335975-m6lkrehi 1681 28 risk risk NN cord-335975-m6lkrehi 1681 29 of of IN cord-335975-m6lkrehi 1681 30 secondary secondary JJ cord-335975-m6lkrehi 1681 31 infections infection NNS cord-335975-m6lkrehi 1681 32 . . . cord-335975-m6lkrehi 1682 1 Staphylococcus Staphylococcus NNP cord-335975-m6lkrehi 1682 2 aureus aureus NN cord-335975-m6lkrehi 1682 3 ( ( -LRB- cord-335975-m6lkrehi 1682 4 SA SA NNP cord-335975-m6lkrehi 1682 5 ) ) -RRB- cord-335975-m6lkrehi 1682 6 is be VBZ cord-335975-m6lkrehi 1682 7 one one CD cord-335975-m6lkrehi 1682 8 of of IN cord-335975-m6lkrehi 1682 9 the the DT cord-335975-m6lkrehi 1682 10 most most RBS cord-335975-m6lkrehi 1682 11 commonly commonly RB cord-335975-m6lkrehi 1682 12 encountered encounter VBN cord-335975-m6lkrehi 1682 13 bacterial bacterial JJ cord-335975-m6lkrehi 1682 14 pathogen pathogen NN cord-335975-m6lkrehi 1682 15 responsible responsible JJ cord-335975-m6lkrehi 1682 16 for for IN cord-335975-m6lkrehi 1682 17 poststernotomy poststernotomy NNP cord-335975-m6lkrehi 1682 18 mediastinitis mediastinitis NNP cord-335975-m6lkrehi 1682 19 , , , cord-335975-m6lkrehi 1682 20 and and CC cord-335975-m6lkrehi 1682 21 neutrophils neutrophil NNS cord-335975-m6lkrehi 1682 22 alterations alteration NNS cord-335975-m6lkrehi 1682 23 may may MD cord-335975-m6lkrehi 1682 24 favor favor VB cord-335975-m6lkrehi 1682 25 postoperative postoperative JJ cord-335975-m6lkrehi 1682 26 infections infection NNS cord-335975-m6lkrehi 1682 27 . . . cord-335975-m6lkrehi 1683 1 The the DT cord-335975-m6lkrehi 1683 2 main main JJ cord-335975-m6lkrehi 1683 3 objectives objective NNS cord-335975-m6lkrehi 1683 4 of of IN cord-335975-m6lkrehi 1683 5 this this DT cord-335975-m6lkrehi 1683 6 study study NN cord-335975-m6lkrehi 1683 7 were be VBD cord-335975-m6lkrehi 1683 8 to to TO cord-335975-m6lkrehi 1683 9 evaluate evaluate VB cord-335975-m6lkrehi 1683 10 the the DT cord-335975-m6lkrehi 1683 11 direct direct JJ cord-335975-m6lkrehi 1683 12 effects effect NNS cord-335975-m6lkrehi 1683 13 of of IN cord-335975-m6lkrehi 1683 14 CBP CBP NNP cord-335975-m6lkrehi 1683 15 on on IN cord-335975-m6lkrehi 1683 16 neutrophils neutrophil NNS cord-335975-m6lkrehi 1683 17 functions function NNS cord-335975-m6lkrehi 1683 18 and and CC cord-335975-m6lkrehi 1683 19 to to TO cord-335975-m6lkrehi 1683 20 study study VB cord-335975-m6lkrehi 1683 21 the the DT cord-335975-m6lkrehi 1683 22 impact impact NN cord-335975-m6lkrehi 1683 23 of of IN cord-335975-m6lkrehi 1683 24 different different JJ cord-335975-m6lkrehi 1683 25 strains strain NNS cord-335975-m6lkrehi 1683 26 of of IN cord-335975-m6lkrehi 1683 27 SA SA NNP cord-335975-m6lkrehi 1683 28 on on IN cord-335975-m6lkrehi 1683 29 neutrophils neutrophil NNS cord-335975-m6lkrehi 1683 30 bactericidal bactericidal JJ cord-335975-m6lkrehi 1683 31 functions function NNS cord-335975-m6lkrehi 1683 32 . . . cord-335975-m6lkrehi 1684 1 Patients patient NNS cord-335975-m6lkrehi 1684 2 and and CC cord-335975-m6lkrehi 1684 3 methods method NNS cord-335975-m6lkrehi 1684 4 : : : cord-335975-m6lkrehi 1684 5 Blood blood NN cord-335975-m6lkrehi 1684 6 samples sample NNS cord-335975-m6lkrehi 1684 7 were be VBD cord-335975-m6lkrehi 1684 8 collected collect VBN cord-335975-m6lkrehi 1684 9 before before RB cord-335975-m6lkrehi 1684 10 and and CC cord-335975-m6lkrehi 1684 11 24 24 CD cord-335975-m6lkrehi 1684 12 h h NN cord-335975-m6lkrehi 1684 13 after after IN cord-335975-m6lkrehi 1684 14 cardiac cardiac JJ cord-335975-m6lkrehi 1684 15 surgery surgery NN cord-335975-m6lkrehi 1684 16 with with IN cord-335975-m6lkrehi 1684 17 CPB CPB NNP cord-335975-m6lkrehi 1684 18 and and CC cord-335975-m6lkrehi 1684 19 bone bone NN cord-335975-m6lkrehi 1684 20 marrow marrow NN cord-335975-m6lkrehi 1684 21 samples sample NNS cord-335975-m6lkrehi 1684 22 were be VBD cord-335975-m6lkrehi 1684 23 harvested harvest VBN cord-335975-m6lkrehi 1684 24 directly directly RB cord-335975-m6lkrehi 1684 25 after after IN cord-335975-m6lkrehi 1684 26 sternotomy sternotomy NN cord-335975-m6lkrehi 1684 27 , , , cord-335975-m6lkrehi 1684 28 before before IN cord-335975-m6lkrehi 1684 29 initiation initiation NN cord-335975-m6lkrehi 1684 30 of of IN cord-335975-m6lkrehi 1684 31 CPB CPB NNP cord-335975-m6lkrehi 1684 32 , , , cord-335975-m6lkrehi 1684 33 and and CC cord-335975-m6lkrehi 1684 34 at at IN cord-335975-m6lkrehi 1684 35 the the DT cord-335975-m6lkrehi 1684 36 end end NN cord-335975-m6lkrehi 1684 37 of of IN cord-335975-m6lkrehi 1684 38 CPB CPB NNP cord-335975-m6lkrehi 1684 39 , , , cord-335975-m6lkrehi 1684 40 before before IN cord-335975-m6lkrehi 1684 41 sternal sternal JJ cord-335975-m6lkrehi 1684 42 closure closure NN cord-335975-m6lkrehi 1684 43 . . . cord-335975-m6lkrehi 1685 1 Septic septic JJ cord-335975-m6lkrehi 1685 2 patients patient NNS cord-335975-m6lkrehi 1685 3 were be VBD cord-335975-m6lkrehi 1685 4 included include VBN cord-335975-m6lkrehi 1685 5 as as IN cord-335975-m6lkrehi 1685 6 controls control NNS cord-335975-m6lkrehi 1685 7 . . . cord-335975-m6lkrehi 1686 1 Circulating circulate VBG cord-335975-m6lkrehi 1686 2 neutrophils neutrophil NNS cord-335975-m6lkrehi 1686 3 analysis analysis NN cord-335975-m6lkrehi 1686 4 was be VBD cord-335975-m6lkrehi 1686 5 performed perform VBN cord-335975-m6lkrehi 1686 6 using use VBG cord-335975-m6lkrehi 1686 7 flow flow NN cord-335975-m6lkrehi 1686 8 cytometry cytometry NN cord-335975-m6lkrehi 1686 9 . . . cord-335975-m6lkrehi 1687 1 We -PRON- PRP cord-335975-m6lkrehi 1687 2 also also RB cord-335975-m6lkrehi 1687 3 studied study VBD cord-335975-m6lkrehi 1687 4 NETosis NETosis NNP cord-335975-m6lkrehi 1687 5 , , , cord-335975-m6lkrehi 1687 6 ROS ROS NNP cord-335975-m6lkrehi 1687 7 production production NN cord-335975-m6lkrehi 1687 8 and and CC cord-335975-m6lkrehi 1687 9 bactericidal bactericidal JJ cord-335975-m6lkrehi 1687 10 activity activity NN cord-335975-m6lkrehi 1687 11 in in IN cord-335975-m6lkrehi 1687 12 isolated isolated JJ cord-335975-m6lkrehi 1687 13 neutrophils neutrophil NNS cord-335975-m6lkrehi 1687 14 before before IN cord-335975-m6lkrehi 1687 15 and and CC cord-335975-m6lkrehi 1687 16 after after IN cord-335975-m6lkrehi 1687 17 surgery surgery NN cord-335975-m6lkrehi 1687 18 using use VBG cord-335975-m6lkrehi 1687 19 two two CD cord-335975-m6lkrehi 1687 20 strains strain NNS cord-335975-m6lkrehi 1687 21 of of IN cord-335975-m6lkrehi 1687 22 SA sa NN cord-335975-m6lkrehi 1687 23 - - HYPH cord-335975-m6lkrehi 1687 24 one one CD cord-335975-m6lkrehi 1687 25 responsible responsible JJ cord-335975-m6lkrehi 1687 26 of of IN cord-335975-m6lkrehi 1687 27 postoperative postoperative JJ cord-335975-m6lkrehi 1687 28 mediastinitis mediastinitis NN cord-335975-m6lkrehi 1687 29 and and CC cord-335975-m6lkrehi 1687 30 one one CD cord-335975-m6lkrehi 1687 31 isolated isolate VBN cord-335975-m6lkrehi 1687 32 from from IN cord-335975-m6lkrehi 1687 33 nasal nasal NN cord-335975-m6lkrehi 1687 34 carriage carriage NN cord-335975-m6lkrehi 1687 35 . . . cord-335975-m6lkrehi 1688 1 Results result NNS cord-335975-m6lkrehi 1688 2 : : : cord-335975-m6lkrehi 1689 1 Blood blood NN cord-335975-m6lkrehi 1689 2 cell cell NN cord-335975-m6lkrehi 1689 3 count count NN cord-335975-m6lkrehi 1689 4 with with IN cord-335975-m6lkrehi 1689 5 differential differential NN cord-335975-m6lkrehi 1689 6 demonstrated demonstrate VBD cord-335975-m6lkrehi 1689 7 a a DT cord-335975-m6lkrehi 1689 8 significant significant JJ cord-335975-m6lkrehi 1689 9 increase increase NN cord-335975-m6lkrehi 1689 10 in in IN cord-335975-m6lkrehi 1689 11 neutrophils neutrophil NNS cord-335975-m6lkrehi 1689 12 24 24 CD cord-335975-m6lkrehi 1689 13 h h NN cord-335975-m6lkrehi 1689 14 after after IN cord-335975-m6lkrehi 1689 15 surgery surgery NN cord-335975-m6lkrehi 1689 16 . . . cord-335975-m6lkrehi 1690 1 Flow flow NN cord-335975-m6lkrehi 1690 2 cytometry cytometry NN cord-335975-m6lkrehi 1690 3 analysis analysis NN cord-335975-m6lkrehi 1690 4 of of IN cord-335975-m6lkrehi 1690 5 blood blood NN cord-335975-m6lkrehi 1690 6 samples sample NNS cord-335975-m6lkrehi 1690 7 indicated indicate VBD cord-335975-m6lkrehi 1690 8 neutrophils neutrophil NNS cord-335975-m6lkrehi 1690 9 were be VBD cord-335975-m6lkrehi 1690 10 matures mature VBZ cord-335975-m6lkrehi 1690 11 with with IN cord-335975-m6lkrehi 1690 12 a a DT cord-335975-m6lkrehi 1690 13 significant significant JJ cord-335975-m6lkrehi 1690 14 increase increase NN cord-335975-m6lkrehi 1690 15 in in IN cord-335975-m6lkrehi 1690 16 degranulation degranulation NN cord-335975-m6lkrehi 1690 17 marker marker NN cord-335975-m6lkrehi 1690 18 ( ( -LRB- cord-335975-m6lkrehi 1690 19 CD66b cd66b NN cord-335975-m6lkrehi 1690 20 ) ) -RRB- cord-335975-m6lkrehi 1690 21 . . . cord-335975-m6lkrehi 1691 1 Neutrophils neutrophils NN cord-335975-m6lkrehi 1691 2 life life NN cord-335975-m6lkrehi 1691 3 span span NN cord-335975-m6lkrehi 1691 4 was be VBD cord-335975-m6lkrehi 1691 5 also also RB cord-335975-m6lkrehi 1691 6 increased increase VBN cord-335975-m6lkrehi 1691 7 after after IN cord-335975-m6lkrehi 1691 8 CBP CBP NNP cord-335975-m6lkrehi 1691 9 . . . cord-335975-m6lkrehi 1692 1 Flow flow NN cord-335975-m6lkrehi 1692 2 cytometry cytometry NN cord-335975-m6lkrehi 1692 3 analysis analysis NN cord-335975-m6lkrehi 1692 4 of of IN cord-335975-m6lkrehi 1692 5 bone bone NN cord-335975-m6lkrehi 1692 6 marrow marrow NN cord-335975-m6lkrehi 1692 7 samples sample NNS cord-335975-m6lkrehi 1692 8 showed show VBD cord-335975-m6lkrehi 1692 9 no no DT cord-335975-m6lkrehi 1692 10 difference difference NN cord-335975-m6lkrehi 1692 11 in in IN cord-335975-m6lkrehi 1692 12 cell cell NN cord-335975-m6lkrehi 1692 13 composition composition NN cord-335975-m6lkrehi 1692 14 and and CC cord-335975-m6lkrehi 1692 15 maturation maturation NN cord-335975-m6lkrehi 1692 16 before before IN cord-335975-m6lkrehi 1692 17 and and CC cord-335975-m6lkrehi 1692 18 after after IN cord-335975-m6lkrehi 1692 19 CBP CBP NNP cord-335975-m6lkrehi 1692 20 . . . cord-335975-m6lkrehi 1693 1 The the DT cord-335975-m6lkrehi 1693 2 neutrophil neutrophil NN cord-335975-m6lkrehi 1693 3 production production NN cord-335975-m6lkrehi 1693 4 of of IN cord-335975-m6lkrehi 1693 5 ROS ROS NNP cord-335975-m6lkrehi 1693 6 was be VBD cord-335975-m6lkrehi 1693 7 significantly significantly RB cord-335975-m6lkrehi 1693 8 higher high JJR cord-335975-m6lkrehi 1693 9 after after IN cord-335975-m6lkrehi 1693 10 CBP CBP NNP cord-335975-m6lkrehi 1693 11 . . . cord-335975-m6lkrehi 1694 1 However however RB cord-335975-m6lkrehi 1694 2 , , , cord-335975-m6lkrehi 1694 3 CBP CBP NNP cord-335975-m6lkrehi 1694 4 did do VBD cord-335975-m6lkrehi 1694 5 not not RB cord-335975-m6lkrehi 1694 6 impact impact VB cord-335975-m6lkrehi 1694 7 NETs net NNS cord-335975-m6lkrehi 1694 8 formation formation NN cord-335975-m6lkrehi 1694 9 , , , cord-335975-m6lkrehi 1694 10 phagocytosis phagocytosis NN cord-335975-m6lkrehi 1694 11 and and CC cord-335975-m6lkrehi 1694 12 bactericidial bactericidial JJ cord-335975-m6lkrehi 1694 13 function function NN cord-335975-m6lkrehi 1694 14 . . . cord-335975-m6lkrehi 1695 1 Moreover moreover RB cord-335975-m6lkrehi 1695 2 , , , cord-335975-m6lkrehi 1695 3 there there EX cord-335975-m6lkrehi 1695 4 was be VBD cord-335975-m6lkrehi 1695 5 no no DT cord-335975-m6lkrehi 1695 6 difference difference NN cord-335975-m6lkrehi 1695 7 regarding regard VBG cord-335975-m6lkrehi 1695 8 the the DT cord-335975-m6lkrehi 1695 9 phagocytosis phagocytosis NN cord-335975-m6lkrehi 1695 10 and and CC cord-335975-m6lkrehi 1695 11 the the DT cord-335975-m6lkrehi 1695 12 bactericidial bactericidial JJ cord-335975-m6lkrehi 1695 13 activity activity NN cord-335975-m6lkrehi 1695 14 when when WRB cord-335975-m6lkrehi 1695 15 exposed expose VBN cord-335975-m6lkrehi 1695 16 to to IN cord-335975-m6lkrehi 1695 17 the the DT cord-335975-m6lkrehi 1695 18 two two CD cord-335975-m6lkrehi 1695 19 strain strain NN cord-335975-m6lkrehi 1695 20 of of IN cord-335975-m6lkrehi 1695 21 SA SA NNP cord-335975-m6lkrehi 1695 22 . . . cord-335975-m6lkrehi 1696 1 As as IN cord-335975-m6lkrehi 1696 2 expected expect VBN cord-335975-m6lkrehi 1696 3 , , , cord-335975-m6lkrehi 1696 4 immature immature JJ cord-335975-m6lkrehi 1696 5 neutrophils neutrophil NNS cord-335975-m6lkrehi 1696 6 count count NN cord-335975-m6lkrehi 1696 7 was be VBD cord-335975-m6lkrehi 1696 8 significantly significantly RB cord-335975-m6lkrehi 1696 9 increased increase VBN cord-335975-m6lkrehi 1696 10 in in IN cord-335975-m6lkrehi 1696 11 septic septic JJ cord-335975-m6lkrehi 1696 12 patients patient NNS cord-335975-m6lkrehi 1696 13 compared compare VBN cord-335975-m6lkrehi 1696 14 to to IN cord-335975-m6lkrehi 1696 15 cardiac cardiac JJ cord-335975-m6lkrehi 1696 16 surgery surgery NN cord-335975-m6lkrehi 1696 17 patients patient NNS cord-335975-m6lkrehi 1696 18 . . . cord-335975-m6lkrehi 1697 1 These these DT cord-335975-m6lkrehi 1697 2 results result NNS cord-335975-m6lkrehi 1697 3 indicate indicate VBP cord-335975-m6lkrehi 1697 4 that that IN cord-335975-m6lkrehi 1697 5 CBP CBP NNP cord-335975-m6lkrehi 1697 6 promotes promote VBZ cord-335975-m6lkrehi 1697 7 the the DT cord-335975-m6lkrehi 1697 8 recruitment recruitment NN cord-335975-m6lkrehi 1697 9 of of IN cord-335975-m6lkrehi 1697 10 matures mature VBZ cord-335975-m6lkrehi 1697 11 neutrophils neutrophil NNS cord-335975-m6lkrehi 1697 12 via via IN cord-335975-m6lkrehi 1697 13 a a DT cord-335975-m6lkrehi 1697 14 demargination demargination NN cord-335975-m6lkrehi 1697 15 process process NN cord-335975-m6lkrehi 1697 16 . . . cord-335975-m6lkrehi 1698 1 CBP CBP NNP cord-335975-m6lkrehi 1698 2 does do VBZ cord-335975-m6lkrehi 1698 3 not not RB cord-335975-m6lkrehi 1698 4 induce induce VB cord-335975-m6lkrehi 1698 5 neutrophil neutrophil NN cord-335975-m6lkrehi 1698 6 dysfunction dysfunction NN cord-335975-m6lkrehi 1698 7 . . . cord-335975-m6lkrehi 1699 1 Neutrophils neutrophils NN cord-335975-m6lkrehi 1699 2 should should MD cord-335975-m6lkrehi 1699 3 not not RB cord-335975-m6lkrehi 1699 4 be be VB cord-335975-m6lkrehi 1699 5 targeted target VBN cord-335975-m6lkrehi 1699 6 to to TO cord-335975-m6lkrehi 1699 7 decrease decrease VB cord-335975-m6lkrehi 1699 8 postoperative postoperative JJ cord-335975-m6lkrehi 1699 9 infection infection NN cord-335975-m6lkrehi 1699 10 after after IN cord-335975-m6lkrehi 1699 11 CPB CPB NNP cord-335975-m6lkrehi 1699 12 . . . cord-335975-m6lkrehi 1700 1 Introduction introduction NN cord-335975-m6lkrehi 1700 2 : : : cord-335975-m6lkrehi 1701 1 Protein Protein NNP cord-335975-m6lkrehi 1701 2 Tyrosine Tyrosine NNP cord-335975-m6lkrehi 1701 3 Phosphatase Phosphatase NNP cord-335975-m6lkrehi 1701 4 1B 1b NN cord-335975-m6lkrehi 1701 5 ( ( -LRB- cord-335975-m6lkrehi 1701 6 PTP1B ptp1b NN cord-335975-m6lkrehi 1701 7 ) ) -RRB- cord-335975-m6lkrehi 1701 8 is be VBZ cord-335975-m6lkrehi 1701 9 a a DT cord-335975-m6lkrehi 1701 10 negative negative JJ cord-335975-m6lkrehi 1701 11 regulator regulator NN cord-335975-m6lkrehi 1701 12 of of IN cord-335975-m6lkrehi 1701 13 both both CC cord-335975-m6lkrehi 1701 14 NO no DT cord-335975-m6lkrehi 1701 15 production production NN cord-335975-m6lkrehi 1701 16 and and CC cord-335975-m6lkrehi 1701 17 insulin insulin NN cord-335975-m6lkrehi 1701 18 signaling signaling NN cord-335975-m6lkrehi 1701 19 and and CC cord-335975-m6lkrehi 1701 20 has have VBZ cord-335975-m6lkrehi 1701 21 been be VBN cord-335975-m6lkrehi 1701 22 shown show VBN cord-335975-m6lkrehi 1701 23 to to TO cord-335975-m6lkrehi 1701 24 be be VB cord-335975-m6lkrehi 1701 25 an an DT cord-335975-m6lkrehi 1701 26 aggravating aggravating JJ cord-335975-m6lkrehi 1701 27 factor factor NN cord-335975-m6lkrehi 1701 28 in in IN cord-335975-m6lkrehi 1701 29 septic septic JJ cord-335975-m6lkrehi 1701 30 shock shock NN cord-335975-m6lkrehi 1701 31 . . . cord-335975-m6lkrehi 1702 1 Stress stress NN cord-335975-m6lkrehi 1702 2 hyperglycemia hyperglycemia NN cord-335975-m6lkrehi 1702 3 frequently frequently RB cord-335975-m6lkrehi 1702 4 occurs occur VBZ cord-335975-m6lkrehi 1702 5 in in IN cord-335975-m6lkrehi 1702 6 critically critically RB cord-335975-m6lkrehi 1702 7 ill ill JJ cord-335975-m6lkrehi 1702 8 patients patient NNS cord-335975-m6lkrehi 1702 9 and and CC cord-335975-m6lkrehi 1702 10 is be VBZ cord-335975-m6lkrehi 1702 11 associated associate VBN cord-335975-m6lkrehi 1702 12 with with IN cord-335975-m6lkrehi 1702 13 poor poor JJ cord-335975-m6lkrehi 1702 14 outcome outcome NN cord-335975-m6lkrehi 1702 15 . . . cord-335975-m6lkrehi 1703 1 Experimental experimental JJ cord-335975-m6lkrehi 1703 2 studies study NNS cord-335975-m6lkrehi 1703 3 on on IN cord-335975-m6lkrehi 1703 4 transgenic transgenic JJ cord-335975-m6lkrehi 1703 5 mice mouse NNS cord-335975-m6lkrehi 1703 6 have have VBP cord-335975-m6lkrehi 1703 7 shown show VBN cord-335975-m6lkrehi 1703 8 that that IN cord-335975-m6lkrehi 1703 9 PTP1B ptp1b CD cord-335975-m6lkrehi 1703 10 deletion deletion NN cord-335975-m6lkrehi 1703 11 resulted result VBD cord-335975-m6lkrehi 1703 12 in in IN cord-335975-m6lkrehi 1703 13 a a DT cord-335975-m6lkrehi 1703 14 reduced reduce VBN cord-335975-m6lkrehi 1703 15 insulin insulin NN cord-335975-m6lkrehi 1703 16 resistance resistance NN cord-335975-m6lkrehi 1703 17 and and CC cord-335975-m6lkrehi 1703 18 in in IN cord-335975-m6lkrehi 1703 19 a a DT cord-335975-m6lkrehi 1703 20 better well JJR cord-335975-m6lkrehi 1703 21 survival survival NN cord-335975-m6lkrehi 1703 22 during during IN cord-335975-m6lkrehi 1703 23 experimental experimental JJ cord-335975-m6lkrehi 1703 24 model model NN cord-335975-m6lkrehi 1703 25 of of IN cord-335975-m6lkrehi 1703 26 sepsis sepsis NN cord-335975-m6lkrehi 1703 27 . . . cord-335975-m6lkrehi 1704 1 The the DT cord-335975-m6lkrehi 1704 2 main main JJ cord-335975-m6lkrehi 1704 3 objective objective NN cord-335975-m6lkrehi 1704 4 was be VBD cord-335975-m6lkrehi 1704 5 to to TO cord-335975-m6lkrehi 1704 6 study study VB cord-335975-m6lkrehi 1704 7 the the DT cord-335975-m6lkrehi 1704 8 correlation correlation NN cord-335975-m6lkrehi 1704 9 between between IN cord-335975-m6lkrehi 1704 10 the the DT cord-335975-m6lkrehi 1704 11 PTP1B ptp1b CD cord-335975-m6lkrehi 1704 12 gene gene NN cord-335975-m6lkrehi 1704 13 expression expression NN cord-335975-m6lkrehi 1704 14 and and CC cord-335975-m6lkrehi 1704 15 organ organ NN cord-335975-m6lkrehi 1704 16 failure failure NN cord-335975-m6lkrehi 1704 17 ( ( -LRB- cord-335975-m6lkrehi 1704 18 through through IN cord-335975-m6lkrehi 1704 19 the the DT cord-335975-m6lkrehi 1704 20 delta delta NN cord-335975-m6lkrehi 1704 21 SOFA sofa NN cord-335975-m6lkrehi 1704 22 score score NN cord-335975-m6lkrehi 1704 23 between between IN cord-335975-m6lkrehi 1704 24 day day NN cord-335975-m6lkrehi 1704 25 1 1 CD cord-335975-m6lkrehi 1704 26 and and CC cord-335975-m6lkrehi 1704 27 day day NN cord-335975-m6lkrehi 1704 28 5 5 CD cord-335975-m6lkrehi 1704 29 ) ) -RRB- cord-335975-m6lkrehi 1704 30 or or CC cord-335975-m6lkrehi 1704 31 insulin insulin NN cord-335975-m6lkrehi 1704 32 resistance resistance NN cord-335975-m6lkrehi 1704 33 . . . cord-335975-m6lkrehi 1705 1 Patients patient NNS cord-335975-m6lkrehi 1705 2 and and CC cord-335975-m6lkrehi 1705 3 methods method NNS cord-335975-m6lkrehi 1705 4 : : : cord-335975-m6lkrehi 1705 5 Twenty twenty CD cord-335975-m6lkrehi 1705 6 - - HYPH cord-335975-m6lkrehi 1705 7 seven seven CD cord-335975-m6lkrehi 1705 8 healthy healthy JJ cord-335975-m6lkrehi 1705 9 male male JJ cord-335975-m6lkrehi 1705 10 volunteers volunteer NNS cord-335975-m6lkrehi 1705 11 have have VBP cord-335975-m6lkrehi 1705 12 been be VBN cord-335975-m6lkrehi 1705 13 included include VBN cord-335975-m6lkrehi 1705 14 in in IN cord-335975-m6lkrehi 1705 15 this this DT cord-335975-m6lkrehi 1705 16 clinical clinical JJ cord-335975-m6lkrehi 1705 17 trial trial NN cord-335975-m6lkrehi 1705 18 . . . cord-335975-m6lkrehi 1706 1 The the DT cord-335975-m6lkrehi 1706 2 product product NN cord-335975-m6lkrehi 1706 3 was be VBD cord-335975-m6lkrehi 1706 4 administered administer VBN cord-335975-m6lkrehi 1706 5 by by IN cord-335975-m6lkrehi 1706 6 continuous continuous JJ cord-335975-m6lkrehi 1706 7 intravenous intravenous JJ cord-335975-m6lkrehi 1706 8 infusion infusion NN cord-335975-m6lkrehi 1706 9 ( ( -LRB- cord-335975-m6lkrehi 1706 10 CIV CIV NNP cord-335975-m6lkrehi 1706 11 ) ) -RRB- cord-335975-m6lkrehi 1706 12 . . . cord-335975-m6lkrehi 1707 1 A a DT cord-335975-m6lkrehi 1707 2 single single JJ cord-335975-m6lkrehi 1707 3 ascending ascend VBG cord-335975-m6lkrehi 1707 4 dose dose NN cord-335975-m6lkrehi 1707 5 design design NN cord-335975-m6lkrehi 1707 6 with with IN cord-335975-m6lkrehi 1707 7 8 8 CD cord-335975-m6lkrehi 1707 8 dose dose NN cord-335975-m6lkrehi 1707 9 levels level NNS cord-335975-m6lkrehi 1707 10 was be VBD cord-335975-m6lkrehi 1707 11 used use VBN cord-335975-m6lkrehi 1707 12 . . . cord-335975-m6lkrehi 1708 1 Cohorts cohort NNS cord-335975-m6lkrehi 1708 2 1 1 CD cord-335975-m6lkrehi 1708 3 and and CC cord-335975-m6lkrehi 1708 4 2 2 CD cord-335975-m6lkrehi 1708 5 received receive VBD cord-335975-m6lkrehi 1708 6 a a DT cord-335975-m6lkrehi 1708 7 15-min 15-min CD cord-335975-m6lkrehi 1708 8 single single JJ cord-335975-m6lkrehi 1708 9 dose dose NN cord-335975-m6lkrehi 1708 10 of of IN cord-335975-m6lkrehi 1708 11 MOTREM MOTREM NNP cord-335975-m6lkrehi 1708 12 ( ( -LRB- cord-335975-m6lkrehi 1708 13 1 1 CD cord-335975-m6lkrehi 1708 14 and and CC cord-335975-m6lkrehi 1708 15 10 10 CD cord-335975-m6lkrehi 1708 16 mg mg NNS cord-335975-m6lkrehi 1708 17 and and CC cord-335975-m6lkrehi 1708 18 one one CD cord-335975-m6lkrehi 1708 19 and and CC cord-335975-m6lkrehi 1708 20 two two CD cord-335975-m6lkrehi 1708 21 volunteers volunteer NNS cord-335975-m6lkrehi 1708 22 respectively respectively RB cord-335975-m6lkrehi 1708 23 ) ) -RRB- cord-335975-m6lkrehi 1708 24 . . . cord-335975-m6lkrehi 1709 1 Then then RB cord-335975-m6lkrehi 1709 2 , , , cord-335975-m6lkrehi 1709 3 cohorts cohort NNS cord-335975-m6lkrehi 1709 4 3 3 CD cord-335975-m6lkrehi 1709 5 to to TO cord-335975-m6lkrehi 1709 6 8 8 CD cord-335975-m6lkrehi 1709 7 received receive VBD cord-335975-m6lkrehi 1709 8 either either CC cord-335975-m6lkrehi 1709 9 a a DT cord-335975-m6lkrehi 1709 10 15-min 15-min CD cord-335975-m6lkrehi 1709 11 loading loading NN cord-335975-m6lkrehi 1709 12 dose dose NN cord-335975-m6lkrehi 1709 13 ( ( -LRB- cord-335975-m6lkrehi 1709 14 from from IN cord-335975-m6lkrehi 1709 15 0.5 0.5 CD cord-335975-m6lkrehi 1709 16 mg mg NNP cord-335975-m6lkrehi 1709 17 kg kg NNP cord-335975-m6lkrehi 1709 18 to to IN cord-335975-m6lkrehi 1709 19 5 5 CD cord-335975-m6lkrehi 1709 20 mg mg NNP cord-335975-m6lkrehi 1709 21 kg kg NNP cord-335975-m6lkrehi 1709 22 ) ) -RRB- cord-335975-m6lkrehi 1709 23 followed follow VBN cord-335975-m6lkrehi 1709 24 by by IN cord-335975-m6lkrehi 1709 25 7.75-hours 7.75-hours CD cord-335975-m6lkrehi 1709 26 maintenance maintenance NN cord-335975-m6lkrehi 1709 27 dose dose NN cord-335975-m6lkrehi 1709 28 ( ( -LRB- cord-335975-m6lkrehi 1709 29 from from IN cord-335975-m6lkrehi 1709 30 0.03 0.03 CD cord-335975-m6lkrehi 1709 31 mg mg NNP cord-335975-m6lkrehi 1709 32 kg kg NNP cord-335975-m6lkrehi 1709 33 h h NNP cord-335975-m6lkrehi 1709 34 to to IN cord-335975-m6lkrehi 1709 35 6 6 CD cord-335975-m6lkrehi 1709 36 mg mg NN cord-335975-m6lkrehi 1709 37 kg kg NNP cord-335975-m6lkrehi 1709 38 h h NN cord-335975-m6lkrehi 1709 39 ) ) -RRB- cord-335975-m6lkrehi 1709 40 of of IN cord-335975-m6lkrehi 1709 41 MOTREM MOTREM NNP cord-335975-m6lkrehi 1709 42 or or CC cord-335975-m6lkrehi 1709 43 a a DT cord-335975-m6lkrehi 1709 44 matching match VBG cord-335975-m6lkrehi 1709 45 placebo placebo NN cord-335975-m6lkrehi 1709 46 ( ( -LRB- cord-335975-m6lkrehi 1709 47 3 3 CD cord-335975-m6lkrehi 1709 48 - - SYM cord-335975-m6lkrehi 1709 49 1 1 CD cord-335975-m6lkrehi 1709 50 ratio ratio NN cord-335975-m6lkrehi 1709 51 ) ) -RRB- cord-335975-m6lkrehi 1709 52 . . . cord-335975-m6lkrehi 1710 1 All all DT cord-335975-m6lkrehi 1710 2 volunteers volunteer NNS cord-335975-m6lkrehi 1710 3 were be VBD cord-335975-m6lkrehi 1710 4 carefully carefully RB cord-335975-m6lkrehi 1710 5 monitored monitor VBN cord-335975-m6lkrehi 1710 6 . . . cord-335975-m6lkrehi 1711 1 Before before IN cord-335975-m6lkrehi 1711 2 escalation escalation NN cord-335975-m6lkrehi 1711 3 to to IN cord-335975-m6lkrehi 1711 4 the the DT cord-335975-m6lkrehi 1711 5 next next JJ cord-335975-m6lkrehi 1711 6 dose dose NN cord-335975-m6lkrehi 1711 7 level level NN cord-335975-m6lkrehi 1711 8 , , , cord-335975-m6lkrehi 1711 9 safety safety NN cord-335975-m6lkrehi 1711 10 and and CC cord-335975-m6lkrehi 1711 11 PK PK NNP cord-335975-m6lkrehi 1711 12 data datum NNS cord-335975-m6lkrehi 1711 13 of of IN cord-335975-m6lkrehi 1711 14 the the DT cord-335975-m6lkrehi 1711 15 previous previous JJ cord-335975-m6lkrehi 1711 16 dose dose JJ cord-335975-m6lkrehi 1711 17 level level NN cord-335975-m6lkrehi 1711 18 were be VBD cord-335975-m6lkrehi 1711 19 reviewed review VBN cord-335975-m6lkrehi 1711 20 by by IN cord-335975-m6lkrehi 1711 21 a a DT cord-335975-m6lkrehi 1711 22 safety safety NN cord-335975-m6lkrehi 1711 23 review review NN cord-335975-m6lkrehi 1711 24 committee committee NN cord-335975-m6lkrehi 1711 25 . . . cord-335975-m6lkrehi 1712 1 Since since IN cord-335975-m6lkrehi 1712 2 immune immune JJ cord-335975-m6lkrehi 1712 3 system system NN cord-335975-m6lkrehi 1712 4 is be VBZ cord-335975-m6lkrehi 1712 5 at at IN cord-335975-m6lkrehi 1712 6 rest rest NN cord-335975-m6lkrehi 1712 7 in in IN cord-335975-m6lkrehi 1712 8 normal normal JJ cord-335975-m6lkrehi 1712 9 individuals individual NNS cord-335975-m6lkrehi 1712 10 and and CC cord-335975-m6lkrehi 1712 11 thus thus RB cord-335975-m6lkrehi 1712 12 TREM-1 trem-1 JJ cord-335975-m6lkrehi 1712 13 pathway pathway NN cord-335975-m6lkrehi 1712 14 is be VBZ cord-335975-m6lkrehi 1712 15 not not RB cord-335975-m6lkrehi 1712 16 activated activate VBN cord-335975-m6lkrehi 1712 17 , , , cord-335975-m6lkrehi 1712 18 no no DT cord-335975-m6lkrehi 1712 19 pharmacodynamics pharmacodynamic NNS cord-335975-m6lkrehi 1712 20 parameters parameter NNS cord-335975-m6lkrehi 1712 21 were be VBD cord-335975-m6lkrehi 1712 22 analyzed analyze VBN cord-335975-m6lkrehi 1712 23 . . . cord-335975-m6lkrehi 1713 1 The the DT cord-335975-m6lkrehi 1713 2 main main JJ cord-335975-m6lkrehi 1713 3 objectives objective NNS cord-335975-m6lkrehi 1713 4 of of IN cord-335975-m6lkrehi 1713 5 this this DT cord-335975-m6lkrehi 1713 6 trial trial NN cord-335975-m6lkrehi 1713 7 was be VBD cord-335975-m6lkrehi 1713 8 then then RB cord-335975-m6lkrehi 1713 9 to to TO cord-335975-m6lkrehi 1713 10 study study VB cord-335975-m6lkrehi 1713 11 the the DT cord-335975-m6lkrehi 1713 12 safety safety NN cord-335975-m6lkrehi 1713 13 and and CC cord-335975-m6lkrehi 1713 14 pharmacokinetic pharmacokinetic JJ cord-335975-m6lkrehi 1713 15 profile profile NN cord-335975-m6lkrehi 1713 16 of of IN cord-335975-m6lkrehi 1713 17 MOTREM MOTREM NNP cord-335975-m6lkrehi 1713 18 . . . cord-335975-m6lkrehi 1714 1 Results result NNS cord-335975-m6lkrehi 1714 2 : : : cord-335975-m6lkrehi 1715 1 No no DT cord-335975-m6lkrehi 1715 2 product product NN cord-335975-m6lkrehi 1715 3 related relate VBN cord-335975-m6lkrehi 1715 4 changes change NNS cord-335975-m6lkrehi 1715 5 in in IN cord-335975-m6lkrehi 1715 6 vital vital JJ cord-335975-m6lkrehi 1715 7 signs sign NNS cord-335975-m6lkrehi 1715 8 , , , cord-335975-m6lkrehi 1715 9 clinical clinical JJ cord-335975-m6lkrehi 1715 10 nor nor CC cord-335975-m6lkrehi 1715 11 laboratory laboratory NN cord-335975-m6lkrehi 1715 12 parameters parameter NNS cord-335975-m6lkrehi 1715 13 were be VBD cord-335975-m6lkrehi 1715 14 observed observe VBN cord-335975-m6lkrehi 1715 15 . . . cord-335975-m6lkrehi 1716 1 No no DT cord-335975-m6lkrehi 1716 2 product product NN cord-335975-m6lkrehi 1716 3 - - HYPH cord-335975-m6lkrehi 1716 4 related relate VBN cord-335975-m6lkrehi 1716 5 adverse adverse JJ cord-335975-m6lkrehi 1716 6 events event NNS cord-335975-m6lkrehi 1716 7 were be VBD cord-335975-m6lkrehi 1716 8 reported report VBN cord-335975-m6lkrehi 1716 9 . . . cord-335975-m6lkrehi 1717 1 The the DT cord-335975-m6lkrehi 1717 2 PK PK NNP cord-335975-m6lkrehi 1717 3 of of IN cord-335975-m6lkrehi 1717 4 MOTREM MOTREM NNP cord-335975-m6lkrehi 1717 5 was be VBD cord-335975-m6lkrehi 1717 6 linear linear JJ cord-335975-m6lkrehi 1717 7 ; ; : cord-335975-m6lkrehi 1717 8 The the DT cord-335975-m6lkrehi 1717 9 main main JJ cord-335975-m6lkrehi 1717 10 clearance clearance NN cord-335975-m6lkrehi 1717 11 was be VBD cord-335975-m6lkrehi 1717 12 estimated estimate VBN cord-335975-m6lkrehi 1717 13 at at IN cord-335975-m6lkrehi 1717 14 463L 463l CD cord-335975-m6lkrehi 1717 15 / / SYM cord-335975-m6lkrehi 1717 16 h/70 h/70 NNS cord-335975-m6lkrehi 1717 17 kg kg NNS cord-335975-m6lkrehi 1717 18 which which WDT cord-335975-m6lkrehi 1717 19 is be VBZ cord-335975-m6lkrehi 1717 20 higher high JJR cord-335975-m6lkrehi 1717 21 than than IN cord-335975-m6lkrehi 1717 22 the the DT cord-335975-m6lkrehi 1717 23 hepatic hepatic JJ cord-335975-m6lkrehi 1717 24 blood blood NN cord-335975-m6lkrehi 1717 25 flow flow NN cord-335975-m6lkrehi 1717 26 in in IN cord-335975-m6lkrehi 1717 27 human human JJ cord-335975-m6lkrehi 1717 28 ( ( -LRB- cord-335975-m6lkrehi 1717 29 i.e. i.e. FW cord-335975-m6lkrehi 1717 30 , , , cord-335975-m6lkrehi 1717 31 90L 90L NNP cord-335975-m6lkrehi 1717 32 / / SYM cord-335975-m6lkrehi 1717 33 h/70 h/70 CD cord-335975-m6lkrehi 1717 34 kg kg NNP cord-335975-m6lkrehi 1717 35 ) ) -RRB- cord-335975-m6lkrehi 1717 36 and and CC cord-335975-m6lkrehi 1717 37 is be VBZ cord-335975-m6lkrehi 1717 38 therefore therefore RB cord-335975-m6lkrehi 1717 39 indicative indicative JJ cord-335975-m6lkrehi 1717 40 of of IN cord-335975-m6lkrehi 1717 41 an an DT cord-335975-m6lkrehi 1717 42 extensive extensive JJ cord-335975-m6lkrehi 1717 43 enzymatic enzymatic JJ cord-335975-m6lkrehi 1717 44 metabolism metabolism NN cord-335975-m6lkrehi 1717 45 in in IN cord-335975-m6lkrehi 1717 46 blood blood NN cord-335975-m6lkrehi 1717 47 + + CC cord-335975-m6lkrehi 1717 48 effective effective JJ cord-335975-m6lkrehi 1717 49 half half JJ cord-335975-m6lkrehi 1717 50 - - HYPH cord-335975-m6lkrehi 1717 51 life life NN cord-335975-m6lkrehi 1717 52 was be VBD cord-335975-m6lkrehi 1717 53 calculated calculate VBN cord-335975-m6lkrehi 1717 54 to to TO cord-335975-m6lkrehi 1717 55 be be VB cord-335975-m6lkrehi 1717 56 about about RB cord-335975-m6lkrehi 1717 57 3 3 CD cord-335975-m6lkrehi 1717 58 min min NN cord-335975-m6lkrehi 1717 59 . . . cord-335975-m6lkrehi 1718 1 Conclusion conclusion NN cord-335975-m6lkrehi 1718 2 : : : cord-335975-m6lkrehi 1719 1 MOTREM MOTREM NNP cord-335975-m6lkrehi 1719 2 was be VBD cord-335975-m6lkrehi 1719 3 found find VBN cord-335975-m6lkrehi 1719 4 to to TO cord-335975-m6lkrehi 1719 5 be be VB cord-335975-m6lkrehi 1719 6 safe safe JJ cord-335975-m6lkrehi 1719 7 and and CC cord-335975-m6lkrehi 1719 8 well well RB cord-335975-m6lkrehi 1719 9 tolerated tolerate VBN cord-335975-m6lkrehi 1719 10 up up RP cord-335975-m6lkrehi 1719 11 to to IN cord-335975-m6lkrehi 1719 12 the the DT cord-335975-m6lkrehi 1719 13 highest high JJS cord-335975-m6lkrehi 1719 14 dose dose NN cord-335975-m6lkrehi 1719 15 tested test VBN cord-335975-m6lkrehi 1719 16 ( ( -LRB- cord-335975-m6lkrehi 1719 17 5mg 5mg NNP cord-335975-m6lkrehi 1719 18 / / SYM cord-335975-m6lkrehi 1719 19 kg kg NN cord-335975-m6lkrehi 1719 20 for for IN cord-335975-m6lkrehi 1719 21 a a DT cord-335975-m6lkrehi 1719 22 15-min 15-min CD cord-335975-m6lkrehi 1719 23 loading loading NN cord-335975-m6lkrehi 1719 24 dose dose NN cord-335975-m6lkrehi 1719 25 and and CC cord-335975-m6lkrehi 1719 26 6 6 CD cord-335975-m6lkrehi 1719 27 mg mg NN cord-335975-m6lkrehi 1719 28 kg kg NNP cord-335975-m6lkrehi 1719 29 h h NNP cord-335975-m6lkrehi 1719 30 for for IN cord-335975-m6lkrehi 1719 31 a a DT cord-335975-m6lkrehi 1719 32 7.75-hours 7.75-hours CD cord-335975-m6lkrehi 1719 33 maintenance maintenance NN cord-335975-m6lkrehi 1719 34 dose dose NN cord-335975-m6lkrehi 1719 35 ) ) -RRB- cord-335975-m6lkrehi 1719 36 . . . cord-335975-m6lkrehi 1720 1 Safety safety NN cord-335975-m6lkrehi 1720 2 and and CC cord-335975-m6lkrehi 1720 3 pharmacokinetics pharmacokinetic NNS cord-335975-m6lkrehi 1720 4 of of IN cord-335975-m6lkrehi 1720 5 MOTREM MOTREM NNP cord-335975-m6lkrehi 1720 6 is be VBZ cord-335975-m6lkrehi 1720 7 currently currently RB cord-335975-m6lkrehi 1720 8 being be VBG cord-335975-m6lkrehi 1720 9 studied study VBN cord-335975-m6lkrehi 1720 10 in in IN cord-335975-m6lkrehi 1720 11 septic septic JJ cord-335975-m6lkrehi 1720 12 shock shock NN cord-335975-m6lkrehi 1720 13 patients patient NNS cord-335975-m6lkrehi 1720 14 in in IN cord-335975-m6lkrehi 1720 15 a a DT cord-335975-m6lkrehi 1720 16 phase phase NN cord-335975-m6lkrehi 1721 1 IIa IIa NNP cord-335975-m6lkrehi 1721 2 randomised randomise VBD cord-335975-m6lkrehi 1721 3 , , , cord-335975-m6lkrehi 1721 4 double double JJ cord-335975-m6lkrehi 1721 5 - - HYPH cord-335975-m6lkrehi 1721 6 blind blind JJ cord-335975-m6lkrehi 1721 7 , , , cord-335975-m6lkrehi 1721 8 two two CD cord-335975-m6lkrehi 1721 9 - - HYPH cord-335975-m6lkrehi 1721 10 stage stage NN cord-335975-m6lkrehi 1721 11 , , , cord-335975-m6lkrehi 1721 12 placebo placebo NN cord-335975-m6lkrehi 1721 13 controlled control VBN cord-335975-m6lkrehi 1721 14 , , , cord-335975-m6lkrehi 1721 15 international international JJ cord-335975-m6lkrehi 1721 16 , , , cord-335975-m6lkrehi 1721 17 multicenter multicenter JJ cord-335975-m6lkrehi 1721 18 clinical clinical JJ cord-335975-m6lkrehi 1721 19 trial trial NN cord-335975-m6lkrehi 1721 20 ( ( -LRB- cord-335975-m6lkrehi 1721 21 www.clinicaltrials.gov www.clinicaltrials.gov NN cord-335975-m6lkrehi 1721 22 NCT03158948 NCT03158948 NNP cord-335975-m6lkrehi 1721 23 ) ) -RRB- cord-335975-m6lkrehi 1721 24 . . . cord-335975-m6lkrehi 1722 1 -1 -1 LS cord-335975-m6lkrehi 1722 2 ) ) -RRB- cord-335975-m6lkrehi 1722 3 is be VBZ cord-335975-m6lkrehi 1722 4 an an DT cord-335975-m6lkrehi 1722 5 immunoreceptor immunoreceptor NN cord-335975-m6lkrehi 1722 6 expressed express VBN cord-335975-m6lkrehi 1722 7 on on IN cord-335975-m6lkrehi 1722 8 neutrophils neutrophil NNS cord-335975-m6lkrehi 1722 9 and and CC cord-335975-m6lkrehi 1722 10 monocytes monocyte VBZ cord-335975-m6lkrehi 1722 11 macrophages macrophage NNS cord-335975-m6lkrehi 1722 12 whose whose WP$ cord-335975-m6lkrehi 1722 13 role role NN cord-335975-m6lkrehi 1722 14 is be VBZ cord-335975-m6lkrehi 1722 15 to to TO cord-335975-m6lkrehi 1722 16 amplify amplify VB cord-335975-m6lkrehi 1722 17 the the DT cord-335975-m6lkrehi 1722 18 inflammatory inflammatory JJ cord-335975-m6lkrehi 1722 19 response response NN cord-335975-m6lkrehi 1722 20 driven drive VBN cord-335975-m6lkrehi 1722 21 by by IN cord-335975-m6lkrehi 1722 22 Toll Toll NNP cord-335975-m6lkrehi 1722 23 - - HYPH cord-335975-m6lkrehi 1722 24 Like like JJ cord-335975-m6lkrehi 1722 25 Receptors Receptors NNPS cord-335975-m6lkrehi 1722 26 engagement engagement NN cord-335975-m6lkrehi 1722 27 . . . cord-335975-m6lkrehi 1723 1 The the DT cord-335975-m6lkrehi 1723 2 pharmacological pharmacological JJ cord-335975-m6lkrehi 1723 3 inhibition inhibition NN cord-335975-m6lkrehi 1723 4 of of IN cord-335975-m6lkrehi 1723 5 TREM-1 TREM-1 NNP cord-335975-m6lkrehi 1723 6 confers confer VBZ cord-335975-m6lkrehi 1723 7 protection protection NN cord-335975-m6lkrehi 1723 8 in in IN cord-335975-m6lkrehi 1723 9 several several JJ cord-335975-m6lkrehi 1723 10 pre pre JJ cord-335975-m6lkrehi 1723 11 - - JJ cord-335975-m6lkrehi 1723 12 clinical clinical JJ cord-335975-m6lkrehi 1723 13 models model NNS cord-335975-m6lkrehi 1723 14 of of IN cord-335975-m6lkrehi 1723 15 acute acute JJ cord-335975-m6lkrehi 1723 16 inflammation inflammation NN cord-335975-m6lkrehi 1723 17 . . . cord-335975-m6lkrehi 1724 1 In in IN cord-335975-m6lkrehi 1724 2 this this DT cord-335975-m6lkrehi 1724 3 study study NN cord-335975-m6lkrehi 1724 4 , , , cord-335975-m6lkrehi 1724 5 we -PRON- PRP cord-335975-m6lkrehi 1724 6 aimed aim VBD cord-335975-m6lkrehi 1724 7 to to TO cord-335975-m6lkrehi 1724 8 decipher decipher VB cord-335975-m6lkrehi 1724 9 the the DT cord-335975-m6lkrehi 1724 10 role role NN cord-335975-m6lkrehi 1724 11 of of IN cord-335975-m6lkrehi 1724 12 TREM-1 TREM-1 NNP cord-335975-m6lkrehi 1724 13 on on IN cord-335975-m6lkrehi 1724 14 the the DT cord-335975-m6lkrehi 1724 15 endothelium endothelium NN cord-335975-m6lkrehi 1724 16 . . . cord-335975-m6lkrehi 1725 1 We -PRON- PRP cord-335975-m6lkrehi 1725 2 evaluated evaluate VBD cord-335975-m6lkrehi 1725 3 the the DT cord-335975-m6lkrehi 1725 4 expression expression NN cord-335975-m6lkrehi 1725 5 of of IN cord-335975-m6lkrehi 1725 6 Trem-1 Trem-1 NNP cord-335975-m6lkrehi 1725 7 in in IN cord-335975-m6lkrehi 1725 8 vessels vessel NNS cord-335975-m6lkrehi 1725 9 and and CC cord-335975-m6lkrehi 1725 10 isolated isolate VBN cord-335975-m6lkrehi 1725 11 endothelial endothelial JJ cord-335975-m6lkrehi 1725 12 cells cell NNS cord-335975-m6lkrehi 1725 13 by by IN cord-335975-m6lkrehi 1725 14 flow flow NN cord-335975-m6lkrehi 1725 15 cytometry cytometry NN cord-335975-m6lkrehi 1725 16 , , , cord-335975-m6lkrehi 1725 17 qRT qRT NNP cord-335975-m6lkrehi 1725 18 - - HYPH cord-335975-m6lkrehi 1725 19 PCR PCR NNP cord-335975-m6lkrehi 1725 20 and and CC cord-335975-m6lkrehi 1725 21 confocal confocal JJ cord-335975-m6lkrehi 1725 22 microscopy microscopy NNS cord-335975-m6lkrehi 1725 23 . . . cord-335975-m6lkrehi 1726 1 We -PRON- PRP cord-335975-m6lkrehi 1726 2 generated generate VBD cord-335975-m6lkrehi 1726 3 an an DT cord-335975-m6lkrehi 1726 4 endothelium endothelium NN cord-335975-m6lkrehi 1726 5 - - HYPH cord-335975-m6lkrehi 1726 6 conditional conditional JJ cord-335975-m6lkrehi 1726 7 Trem-1 Trem-1 NNP cord-335975-m6lkrehi 1726 8 ko ko NNP cord-335975-m6lkrehi 1726 9 mice mouse NNS cord-335975-m6lkrehi 1726 10 and and CC cord-335975-m6lkrehi 1726 11 submitted submit VBD cord-335975-m6lkrehi 1726 12 them -PRON- PRP cord-335975-m6lkrehi 1726 13 to to IN cord-335975-m6lkrehi 1726 14 polymicrobial polymicrobial JJ cord-335975-m6lkrehi 1726 15 sepsis sepsis NN cord-335975-m6lkrehi 1726 16 through through IN cord-335975-m6lkrehi 1726 17 CLP CLP NNP cord-335975-m6lkrehi 1726 18 . . . cord-335975-m6lkrehi 1727 1 Organs organ NNS cord-335975-m6lkrehi 1727 2 and and CC cord-335975-m6lkrehi 1727 3 blood blood NN cord-335975-m6lkrehi 1727 4 were be VBD cord-335975-m6lkrehi 1727 5 harvested harvest VBN cord-335975-m6lkrehi 1727 6 at at IN cord-335975-m6lkrehi 1727 7 different different JJ cord-335975-m6lkrehi 1727 8 time time NN cord-335975-m6lkrehi 1727 9 points point NNS cord-335975-m6lkrehi 1727 10 and and CC cord-335975-m6lkrehi 1727 11 analyzed analyze VBD cord-335975-m6lkrehi 1727 12 for for IN cord-335975-m6lkrehi 1727 13 cellular cellular JJ cord-335975-m6lkrehi 1727 14 content content NN cord-335975-m6lkrehi 1727 15 , , , cord-335975-m6lkrehi 1727 16 cytokine cytokine NN cord-335975-m6lkrehi 1727 17 chemokine chemokine NN cord-335975-m6lkrehi 1727 18 concentrations concentration NNS cord-335975-m6lkrehi 1727 19 , , , cord-335975-m6lkrehi 1727 20 and and CC cord-335975-m6lkrehi 1727 21 vasoreactivity vasoreactivity NN cord-335975-m6lkrehi 1727 22 . . . cord-335975-m6lkrehi 1728 1 Survival survival NN cord-335975-m6lkrehi 1728 2 was be VBD cord-335975-m6lkrehi 1728 3 monitored monitor VBN cord-335975-m6lkrehi 1728 4 for for IN cord-335975-m6lkrehi 1728 5 1 1 CD cord-335975-m6lkrehi 1728 6 week week NN cord-335975-m6lkrehi 1728 7 . . . cord-335975-m6lkrehi 1729 1 Results result NNS cord-335975-m6lkrehi 1729 2 : : : cord-335975-m6lkrehi 1730 1 Trem-1 Trem-1 NNP cord-335975-m6lkrehi 1730 2 was be VBD cord-335975-m6lkrehi 1730 3 expressed express VBN cord-335975-m6lkrehi 1730 4 in in IN cord-335975-m6lkrehi 1730 5 aorta aorta NN cord-335975-m6lkrehi 1730 6 and and CC cord-335975-m6lkrehi 1730 7 pulmonary pulmonary JJ cord-335975-m6lkrehi 1730 8 vessels vessel NNS cord-335975-m6lkrehi 1730 9 from from IN cord-335975-m6lkrehi 1730 10 animals animal NNS cord-335975-m6lkrehi 1730 11 , , , cord-335975-m6lkrehi 1730 12 and and CC cord-335975-m6lkrehi 1730 13 inducible inducible JJ cord-335975-m6lkrehi 1730 14 after after IN cord-335975-m6lkrehi 1730 15 LPS LPS NNP cord-335975-m6lkrehi 1730 16 stimulation stimulation NN cord-335975-m6lkrehi 1730 17 or or CC cord-335975-m6lkrehi 1730 18 during during IN cord-335975-m6lkrehi 1730 19 sepsis sepsis NN cord-335975-m6lkrehi 1730 20 . . . cord-335975-m6lkrehi 1731 1 These these DT cord-335975-m6lkrehi 1731 2 results result NNS cord-335975-m6lkrehi 1731 3 were be VBD cord-335975-m6lkrehi 1731 4 confirmed confirm VBN cord-335975-m6lkrehi 1731 5 in in IN cord-335975-m6lkrehi 1731 6 human human JJ cord-335975-m6lkrehi 1731 7 pulmonary pulmonary JJ cord-335975-m6lkrehi 1731 8 microvascular microvascular JJ cord-335975-m6lkrehi 1731 9 endothelial endothelial JJ cord-335975-m6lkrehi 1731 10 cells cell NNS cord-335975-m6lkrehi 1731 11 . . . cord-335975-m6lkrehi 1732 1 The the DT cord-335975-m6lkrehi 1732 2 pharmacological pharmacological JJ cord-335975-m6lkrehi 1732 3 inhibition inhibition NN cord-335975-m6lkrehi 1732 4 of of IN cord-335975-m6lkrehi 1732 5 TREM-1 TREM-1 NNP cord-335975-m6lkrehi 1732 6 , , , cord-335975-m6lkrehi 1732 7 using use VBG cord-335975-m6lkrehi 1732 8 the the DT cord-335975-m6lkrehi 1732 9 synthetic synthetic JJ cord-335975-m6lkrehi 1732 10 inhibitory inhibitory JJ cord-335975-m6lkrehi 1732 11 peptide peptide NN cord-335975-m6lkrehi 1732 12 LR12 LR12 NNP cord-335975-m6lkrehi 1732 13 , , , cord-335975-m6lkrehi 1732 14 decreased decrease VBD cord-335975-m6lkrehi 1732 15 the the DT cord-335975-m6lkrehi 1732 16 LPS LPS NNP cord-335975-m6lkrehi 1732 17 - - HYPH cord-335975-m6lkrehi 1732 18 induced induce VBN cord-335975-m6lkrehi 1732 19 Trem-1 trem-1 CD cord-335975-m6lkrehi 1732 20 expression expression NN cord-335975-m6lkrehi 1732 21 . . . cord-335975-m6lkrehi 1733 1 Sepsis sepsis NN cord-335975-m6lkrehi 1733 2 induced induce VBD cord-335975-m6lkrehi 1733 3 a a DT cord-335975-m6lkrehi 1733 4 profound profound JJ cord-335975-m6lkrehi 1733 5 vascular vascular JJ cord-335975-m6lkrehi 1733 6 hyporeactivity hyporeactivity NN cord-335975-m6lkrehi 1733 7 in in IN cord-335975-m6lkrehi 1733 8 WT WT NNP cord-335975-m6lkrehi 1733 9 animals animal NNS cord-335975-m6lkrehi 1733 10 , , , cord-335975-m6lkrehi 1733 11 both both CC cord-335975-m6lkrehi 1733 12 in in IN cord-335975-m6lkrehi 1733 13 terms term NNS cord-335975-m6lkrehi 1733 14 of of IN cord-335975-m6lkrehi 1733 15 contractility contractility NN cord-335975-m6lkrehi 1733 16 and and CC cord-335975-m6lkrehi 1733 17 endothelium endothelium NN cord-335975-m6lkrehi 1733 18 - - HYPH cord-335975-m6lkrehi 1733 19 dependent dependent JJ cord-335975-m6lkrehi 1733 20 relaxation relaxation NN cord-335975-m6lkrehi 1733 21 . . . cord-335975-m6lkrehi 1734 1 Although although IN cord-335975-m6lkrehi 1734 2 contractility contractility NN cord-335975-m6lkrehi 1734 3 was be VBD cord-335975-m6lkrehi 1734 4 still still RB cord-335975-m6lkrehi 1734 5 impaired impair VBN cord-335975-m6lkrehi 1734 6 in in IN cord-335975-m6lkrehi 1734 7 EndoTREM-1-mice endotrem-1-mice NN cord-335975-m6lkrehi 1734 8 , , , cord-335975-m6lkrehi 1734 9 vasorelaxation vasorelaxation NN cord-335975-m6lkrehi 1734 10 was be VBD cord-335975-m6lkrehi 1734 11 completely completely RB cord-335975-m6lkrehi 1734 12 restored restore VBN cord-335975-m6lkrehi 1734 13 . . . cord-335975-m6lkrehi 1735 1 Soluble soluble JJ cord-335975-m6lkrehi 1735 2 TREM-1 TREM-1 NNP cord-335975-m6lkrehi 1735 3 concentrations concentration NNS cord-335975-m6lkrehi 1735 4 , , , cord-335975-m6lkrehi 1735 5 a a DT cord-335975-m6lkrehi 1735 6 marker marker NN cord-335975-m6lkrehi 1735 7 of of IN cord-335975-m6lkrehi 1735 8 TREM-1 TREM-1 NNP cord-335975-m6lkrehi 1735 9 activation activation NN cord-335975-m6lkrehi 1735 10 , , , cord-335975-m6lkrehi 1735 11 were be VBD cord-335975-m6lkrehi 1735 12 markedly markedly RB cord-335975-m6lkrehi 1735 13 increased increase VBN cord-335975-m6lkrehi 1735 14 in in IN cord-335975-m6lkrehi 1735 15 the the DT cord-335975-m6lkrehi 1735 16 plasma plasma NN cord-335975-m6lkrehi 1735 17 , , , cord-335975-m6lkrehi 1735 18 the the DT cord-335975-m6lkrehi 1735 19 peritoneal peritoneal NN cord-335975-m6lkrehi 1735 20 lavage lavage NN cord-335975-m6lkrehi 1735 21 fluid fluid NN cord-335975-m6lkrehi 1735 22 and and CC cord-335975-m6lkrehi 1735 23 the the DT cord-335975-m6lkrehi 1735 24 lungs lung NNS cord-335975-m6lkrehi 1735 25 from from IN cord-335975-m6lkrehi 1735 26 WT wt NN cord-335975-m6lkrehi 1735 27 septic septic JJ cord-335975-m6lkrehi 1735 28 mice mouse NNS cord-335975-m6lkrehi 1735 29 compared compare VBN cord-335975-m6lkrehi 1735 30 to to IN cord-335975-m6lkrehi 1735 31 control control NN cord-335975-m6lkrehi 1735 32 . . . cord-335975-m6lkrehi 1736 1 In in IN cord-335975-m6lkrehi 1736 2 EndoTREM-1-mice EndoTREM-1-mice NNS cord-335975-m6lkrehi 1736 3 , , , cord-335975-m6lkrehi 1736 4 sTREM-1 strem-1 CD cord-335975-m6lkrehi 1736 5 level level NN cord-335975-m6lkrehi 1736 6 was be VBD cord-335975-m6lkrehi 1736 7 reduced reduce VBN cord-335975-m6lkrehi 1736 8 . . . cord-335975-m6lkrehi 1737 1 Plasma plasma NN cord-335975-m6lkrehi 1737 2 concentrations concentration NNS cord-335975-m6lkrehi 1737 3 of of IN cord-335975-m6lkrehi 1737 4 soluble soluble JJ cord-335975-m6lkrehi 1737 5 VCAM-1 VCAM-1 NNP cord-335975-m6lkrehi 1737 6 and and CC cord-335975-m6lkrehi 1737 7 IL-6 IL-6 NNP cord-335975-m6lkrehi 1737 8 were be VBD cord-335975-m6lkrehi 1737 9 also also RB cord-335975-m6lkrehi 1737 10 reduced reduce VBN cord-335975-m6lkrehi 1737 11 in in IN cord-335975-m6lkrehi 1737 12 EndoTREM-1-animals endotrem-1-animal NNS cord-335975-m6lkrehi 1737 13 . . . cord-335975-m6lkrehi 1738 1 We -PRON- PRP cord-335975-m6lkrehi 1738 2 observed observe VBD cord-335975-m6lkrehi 1738 3 an an DT cord-335975-m6lkrehi 1738 4 accumulation accumulation NN cord-335975-m6lkrehi 1738 5 of of IN cord-335975-m6lkrehi 1738 6 neutrophils neutrophil NNS cord-335975-m6lkrehi 1738 7 and and CC cord-335975-m6lkrehi 1738 8 inflammatory inflammatory JJ cord-335975-m6lkrehi 1738 9 Ly6Chigh Ly6Chigh NNP cord-335975-m6lkrehi 1738 10 monocytes monocyte NNS cord-335975-m6lkrehi 1738 11 in in IN cord-335975-m6lkrehi 1738 12 the the DT cord-335975-m6lkrehi 1738 13 lung lung NN cord-335975-m6lkrehi 1738 14 of of IN cord-335975-m6lkrehi 1738 15 WT WT NNP cord-335975-m6lkrehi 1738 16 septic septic JJ cord-335975-m6lkrehi 1738 17 mice mouse NNS cord-335975-m6lkrehi 1738 18 . . . cord-335975-m6lkrehi 1739 1 This this DT cord-335975-m6lkrehi 1739 2 accumulation accumulation NN cord-335975-m6lkrehi 1739 3 was be VBD cord-335975-m6lkrehi 1739 4 dampened dampen VBN cord-335975-m6lkrehi 1739 5 in in IN cord-335975-m6lkrehi 1739 6 EndoTrem-1-mice EndoTrem-1-mice NNP cord-335975-m6lkrehi 1739 7 . . . cord-335975-m6lkrehi 1740 1 By by IN cord-335975-m6lkrehi 1740 2 contrast contrast NN cord-335975-m6lkrehi 1740 3 , , , cord-335975-m6lkrehi 1740 4 endothelial endothelial JJ cord-335975-m6lkrehi 1740 5 Trem-1 trem-1 CD cord-335975-m6lkrehi 1740 6 deletion deletion NN cord-335975-m6lkrehi 1740 7 favored favor VBD cord-335975-m6lkrehi 1740 8 the the DT cord-335975-m6lkrehi 1740 9 accumulation accumulation NN cord-335975-m6lkrehi 1740 10 of of IN cord-335975-m6lkrehi 1740 11 reparative reparative JJ cord-335975-m6lkrehi 1740 12 cells cell NNS cord-335975-m6lkrehi 1740 13 ( ( -LRB- cord-335975-m6lkrehi 1740 14 Ly6Clow Ly6Clow NNP cord-335975-m6lkrehi 1740 15 monocytes monocyte NNS cord-335975-m6lkrehi 1740 16 ) ) -RRB- cord-335975-m6lkrehi 1740 17 . . . cord-335975-m6lkrehi 1741 1 Finally finally RB cord-335975-m6lkrehi 1741 2 , , , cord-335975-m6lkrehi 1741 3 survival survival NN cord-335975-m6lkrehi 1741 4 was be VBD cord-335975-m6lkrehi 1741 5 clearly clearly RB cord-335975-m6lkrehi 1741 6 improved improve VBN cord-335975-m6lkrehi 1741 7 in in IN cord-335975-m6lkrehi 1741 8 the the DT cord-335975-m6lkrehi 1741 9 EndoTrem-1-group EndoTrem-1-group NNP cord-335975-m6lkrehi 1741 10 as as IN cord-335975-m6lkrehi 1741 11 compared compare VBN cord-335975-m6lkrehi 1741 12 to to IN cord-335975-m6lkrehi 1741 13 the the DT cord-335975-m6lkrehi 1741 14 WT WT NNP cord-335975-m6lkrehi 1741 15 group group NN cord-335975-m6lkrehi 1741 16 . . . cord-335975-m6lkrehi 1742 1 Conclusion conclusion NN cord-335975-m6lkrehi 1742 2 : : : cord-335975-m6lkrehi 1743 1 We -PRON- PRP cord-335975-m6lkrehi 1743 2 reported report VBD cord-335975-m6lkrehi 1743 3 that that IN cord-335975-m6lkrehi 1743 4 TREM-1 TREM-1 NNP cord-335975-m6lkrehi 1743 5 is be VBZ cord-335975-m6lkrehi 1743 6 expressed express VBN cord-335975-m6lkrehi 1743 7 and and CC cord-335975-m6lkrehi 1743 8 inducible inducible JJ cord-335975-m6lkrehi 1743 9 in in IN cord-335975-m6lkrehi 1743 10 endothelial endothelial JJ cord-335975-m6lkrehi 1743 11 cells cell NNS cord-335975-m6lkrehi 1743 12 and and CC cord-335975-m6lkrehi 1743 13 plays play VBZ cord-335975-m6lkrehi 1743 14 a a DT cord-335975-m6lkrehi 1743 15 direct direct JJ cord-335975-m6lkrehi 1743 16 role role NN cord-335975-m6lkrehi 1743 17 in in IN cord-335975-m6lkrehi 1743 18 vascular vascular JJ cord-335975-m6lkrehi 1743 19 inflammation inflammation NN cord-335975-m6lkrehi 1743 20 and and CC cord-335975-m6lkrehi 1743 21 dysfunction dysfunction NN cord-335975-m6lkrehi 1743 22 . . . cord-335975-m6lkrehi 1744 1 The the DT cord-335975-m6lkrehi 1744 2 targeted target VBN cord-335975-m6lkrehi 1744 3 deletion deletion NN cord-335975-m6lkrehi 1744 4 of of IN cord-335975-m6lkrehi 1744 5 endothelial endothelial JJ cord-335975-m6lkrehi 1744 6 Trem-1 Trem-1 NNP cord-335975-m6lkrehi 1744 7 conferred confer VBN cord-335975-m6lkrehi 1744 8 protection protection NN cord-335975-m6lkrehi 1744 9 during during IN cord-335975-m6lkrehi 1744 10 septic septic JJ cord-335975-m6lkrehi 1744 11 shock shock NN cord-335975-m6lkrehi 1744 12 in in IN cord-335975-m6lkrehi 1744 13 modulating modulate VBG cord-335975-m6lkrehi 1744 14 inflammatory inflammatory JJ cord-335975-m6lkrehi 1744 15 cells cell NNS cord-335975-m6lkrehi 1744 16 mobilization mobilization NN cord-335975-m6lkrehi 1744 17 and and CC cord-335975-m6lkrehi 1744 18 activation activation NN cord-335975-m6lkrehi 1744 19 , , , cord-335975-m6lkrehi 1744 20 restoring restore VBG cord-335975-m6lkrehi 1744 21 vasoreactivity vasoreactivity NN cord-335975-m6lkrehi 1744 22 and and CC cord-335975-m6lkrehi 1744 23 improving improve VBG cord-335975-m6lkrehi 1744 24 survival survival NN cord-335975-m6lkrehi 1744 25 . . . cord-335975-m6lkrehi 1745 1 The the DT cord-335975-m6lkrehi 1745 2 effect effect NN cord-335975-m6lkrehi 1745 3 of of IN cord-335975-m6lkrehi 1745 4 TREM-1 TREM-1 NNP cord-335975-m6lkrehi 1745 5 on on IN cord-335975-m6lkrehi 1745 6 vascular vascular JJ cord-335975-m6lkrehi 1745 7 tone tone NN cord-335975-m6lkrehi 1745 8 , , , cord-335975-m6lkrehi 1745 9 while while IN cord-335975-m6lkrehi 1745 10 impressive impressive JJ cord-335975-m6lkrehi 1745 11 , , , cord-335975-m6lkrehi 1745 12 deserves deserve VBZ cord-335975-m6lkrehi 1745 13 further further JJ cord-335975-m6lkrehi 1745 14 investigations investigation NNS cord-335975-m6lkrehi 1745 15 including include VBG cord-335975-m6lkrehi 1745 16 the the DT cord-335975-m6lkrehi 1745 17 design design NN cord-335975-m6lkrehi 1745 18 of of IN cord-335975-m6lkrehi 1745 19 endothelium endothelium NN cord-335975-m6lkrehi 1745 20 specific specific JJ cord-335975-m6lkrehi 1745 21 TREM-1 TREM-1 NNP cord-335975-m6lkrehi 1745 22 inhibitors inhibitor NNS cord-335975-m6lkrehi 1745 23 . . . cord-335975-m6lkrehi 1746 1 -50.5 -50.5 NNP cord-335975-m6lkrehi 1746 2 ] ] -RRB- cord-335975-m6lkrehi 1746 3 . . . cord-335975-m6lkrehi 1747 1 14 14 CD cord-335975-m6lkrehi 1747 2 patients patient NNS cord-335975-m6lkrehi 1747 3 suffered suffer VBD cord-335975-m6lkrehi 1747 4 from from IN cord-335975-m6lkrehi 1747 5 pneumonia pneumonia NN cord-335975-m6lkrehi 1747 6 , , , cord-335975-m6lkrehi 1747 7 6 6 CD cord-335975-m6lkrehi 1747 8 from from IN cord-335975-m6lkrehi 1747 9 intra intra JJ cord-335975-m6lkrehi 1747 10 - - JJ cord-335975-m6lkrehi 1747 11 abdominal abdominal JJ cord-335975-m6lkrehi 1747 12 sepsis sepsis NN cord-335975-m6lkrehi 1747 13 . . . cord-335975-m6lkrehi 1748 1 We -PRON- PRP cord-335975-m6lkrehi 1748 2 measured measure VBD cord-335975-m6lkrehi 1748 3 serum serum NN cord-335975-m6lkrehi 1748 4 levels level NNS cord-335975-m6lkrehi 1748 5 of of IN cord-335975-m6lkrehi 1748 6 total total JJ cord-335975-m6lkrehi 1748 7 and and CC cord-335975-m6lkrehi 1748 8 free free JJ cord-335975-m6lkrehi 1748 9 thiamine thiamine NN cord-335975-m6lkrehi 1748 10 , , , cord-335975-m6lkrehi 1748 11 thiamine thiamine NN cord-335975-m6lkrehi 1748 12 mono mono NN cord-335975-m6lkrehi 1748 13 di di NN cord-335975-m6lkrehi 1748 14 and and CC cord-335975-m6lkrehi 1748 15 triphosphate triphosphate NN cord-335975-m6lkrehi 1748 16 ( ( -LRB- cord-335975-m6lkrehi 1748 17 TMP TMP NNP cord-335975-m6lkrehi 1748 18 , , , cord-335975-m6lkrehi 1748 19 TDP TDP NNP cord-335975-m6lkrehi 1748 20 and and CC cord-335975-m6lkrehi 1748 21 TTP TTP NNP cord-335975-m6lkrehi 1748 22 respectively respectively RB cord-335975-m6lkrehi 1748 23 ) ) -RRB- cord-335975-m6lkrehi 1748 24 , , , cord-335975-m6lkrehi 1748 25 as as RB cord-335975-m6lkrehi 1748 26 well well RB cord-335975-m6lkrehi 1748 27 as as IN cord-335975-m6lkrehi 1748 28 the the DT cord-335975-m6lkrehi 1748 29 erythrocyte erythrocyte NN cord-335975-m6lkrehi 1748 30 transketolase transketolase NN cord-335975-m6lkrehi 1748 31 activity activity NN cord-335975-m6lkrehi 1748 32 and and CC cord-335975-m6lkrehi 1748 33 arterial arterial JJ cord-335975-m6lkrehi 1748 34 lactate lactate NN cord-335975-m6lkrehi 1748 35 at at IN cord-335975-m6lkrehi 1748 36 the the DT cord-335975-m6lkrehi 1748 37 time time NN cord-335975-m6lkrehi 1748 38 of of IN cord-335975-m6lkrehi 1748 39 admission admission NN cord-335975-m6lkrehi 1748 40 . . . cord-335975-m6lkrehi 1749 1 We -PRON- PRP cord-335975-m6lkrehi 1749 2 also also RB cord-335975-m6lkrehi 1749 3 recorded record VBD cord-335975-m6lkrehi 1749 4 the the DT cord-335975-m6lkrehi 1749 5 vital vital JJ cord-335975-m6lkrehi 1749 6 status status NN cord-335975-m6lkrehi 1749 7 at at IN cord-335975-m6lkrehi 1749 8 the the DT cord-335975-m6lkrehi 1749 9 end end NN cord-335975-m6lkrehi 1749 10 of of IN cord-335975-m6lkrehi 1749 11 the the DT cord-335975-m6lkrehi 1749 12 ICU ICU NNP cord-335975-m6lkrehi 1749 13 stay stay NN cord-335975-m6lkrehi 1749 14 . . . cord-335975-m6lkrehi 1750 1 Results result NNS cord-335975-m6lkrehi 1750 2 : : : cord-335975-m6lkrehi 1750 3 50 50 CD cord-335975-m6lkrehi 1750 4 % % NN cord-335975-m6lkrehi 1750 5 of of IN cord-335975-m6lkrehi 1750 6 our -PRON- PRP$ cord-335975-m6lkrehi 1750 7 subjects subject NNS cord-335975-m6lkrehi 1750 8 exhibited exhibit VBD cord-335975-m6lkrehi 1750 9 particularly particularly RB cord-335975-m6lkrehi 1750 10 low low JJ cord-335975-m6lkrehi 1750 11 levels level NNS cord-335975-m6lkrehi 1750 12 of of IN cord-335975-m6lkrehi 1750 13 free free JJ cord-335975-m6lkrehi 1750 14 thiamine thiamine NN cord-335975-m6lkrehi 1750 15 ( ( -LRB- cord-335975-m6lkrehi 1750 16 < < NNP cord-335975-m6lkrehi 1750 17 7 7 CD cord-335975-m6lkrehi 1750 18 nmol nmol NNP cord-335975-m6lkrehi 1750 19 / / SYM cord-335975-m6lkrehi 1750 20 L L NNP cord-335975-m6lkrehi 1750 21 ) ) -RRB- cord-335975-m6lkrehi 1750 22 . . . cord-335975-m6lkrehi 1751 1 There there EX cord-335975-m6lkrehi 1751 2 was be VBD cord-335975-m6lkrehi 1751 3 no no DT cord-335975-m6lkrehi 1751 4 correlation correlation NN cord-335975-m6lkrehi 1751 5 between between IN cord-335975-m6lkrehi 1751 6 free free JJ cord-335975-m6lkrehi 1751 7 ( ( -LRB- cord-335975-m6lkrehi 1751 8 r r NN cord-335975-m6lkrehi 1751 9 = = NN cord-335975-m6lkrehi 1751 10 − − NNP cord-335975-m6lkrehi 1751 11 0.4 0.4 CD cord-335975-m6lkrehi 1751 12 ; ; : cord-335975-m6lkrehi 1751 13 p p NN cord-335975-m6lkrehi 1751 14 = = SYM cord-335975-m6lkrehi 1751 15 0.85 0.85 CD cord-335975-m6lkrehi 1751 16 ) ) -RRB- cord-335975-m6lkrehi 1751 17 , , , cord-335975-m6lkrehi 1751 18 or or CC cord-335975-m6lkrehi 1751 19 total total NN cord-335975-m6lkrehi 1751 20 ( ( -LRB- cord-335975-m6lkrehi 1751 21 r r NN cord-335975-m6lkrehi 1751 22 = = SYM cord-335975-m6lkrehi 1751 23 − − NN cord-335975-m6lkrehi 1751 24 0.19 0.19 CD cord-335975-m6lkrehi 1751 25 ; ; : cord-335975-m6lkrehi 1751 26 p p NN cord-335975-m6lkrehi 1751 27 = = SYM cord-335975-m6lkrehi 1751 28 0.34 0.34 CD cord-335975-m6lkrehi 1751 29 ) ) -RRB- cord-335975-m6lkrehi 1752 1 thiamine thiamine NN cord-335975-m6lkrehi 1752 2 concentration concentration NN cord-335975-m6lkrehi 1752 3 and and CC cord-335975-m6lkrehi 1752 4 lactate lactate NN cord-335975-m6lkrehi 1752 5 levels level NNS cord-335975-m6lkrehi 1752 6 . . . cord-335975-m6lkrehi 1753 1 There there EX cord-335975-m6lkrehi 1753 2 was be VBD cord-335975-m6lkrehi 1753 3 no no DT cord-335975-m6lkrehi 1753 4 correlation correlation NN cord-335975-m6lkrehi 1753 5 between between IN cord-335975-m6lkrehi 1753 6 TMP tmp NN cord-335975-m6lkrehi 1753 7 ( ( -LRB- cord-335975-m6lkrehi 1753 8 r r NN cord-335975-m6lkrehi 1753 9 = = SYM cord-335975-m6lkrehi 1753 10 0.02 0.02 CD cord-335975-m6lkrehi 1753 11 ; ; : cord-335975-m6lkrehi 1753 12 p p NN cord-335975-m6lkrehi 1753 13 = = SYM cord-335975-m6lkrehi 1753 14 0.91 0.91 CD cord-335975-m6lkrehi 1753 15 ) ) -RRB- cord-335975-m6lkrehi 1753 16 , , , cord-335975-m6lkrehi 1753 17 TDP TDP NNP cord-335975-m6lkrehi 1753 18 ( ( -LRB- cord-335975-m6lkrehi 1753 19 r r NN cord-335975-m6lkrehi 1753 20 = = SYM cord-335975-m6lkrehi 1753 21 − − NN cord-335975-m6lkrehi 1753 22 0.19 0.19 CD cord-335975-m6lkrehi 1753 23 ; ; : cord-335975-m6lkrehi 1753 24 p p NN cord-335975-m6lkrehi 1753 25 = = SYM cord-335975-m6lkrehi 1753 26 0.34 0.34 CD cord-335975-m6lkrehi 1753 27 ) ) -RRB- cord-335975-m6lkrehi 1753 28 , , , cord-335975-m6lkrehi 1753 29 TTP TTP NNP cord-335975-m6lkrehi 1753 30 ( ( -LRB- cord-335975-m6lkrehi 1753 31 r r NN cord-335975-m6lkrehi 1753 32 = = SYM cord-335975-m6lkrehi 1753 33 − − NN cord-335975-m6lkrehi 1753 34 0.15 0.15 CD cord-335975-m6lkrehi 1753 35 ; ; : cord-335975-m6lkrehi 1753 36 p p NN cord-335975-m6lkrehi 1753 37 = = SYM cord-335975-m6lkrehi 1753 38 0.46 0.46 CD cord-335975-m6lkrehi 1753 39 ) ) -RRB- cord-335975-m6lkrehi 1753 40 and and CC cord-335975-m6lkrehi 1753 41 lactate lactate NN cord-335975-m6lkrehi 1753 42 levels level NNS cord-335975-m6lkrehi 1753 43 in in IN cord-335975-m6lkrehi 1753 44 the the DT cord-335975-m6lkrehi 1753 45 whole whole JJ cord-335975-m6lkrehi 1753 46 population population NN cord-335975-m6lkrehi 1753 47 . . . cord-335975-m6lkrehi 1754 1 No no DT cord-335975-m6lkrehi 1754 2 correlation correlation NN cord-335975-m6lkrehi 1754 3 was be VBD cord-335975-m6lkrehi 1754 4 found find VBN cord-335975-m6lkrehi 1754 5 between between IN cord-335975-m6lkrehi 1754 6 the the DT cord-335975-m6lkrehi 1754 7 concentration concentration NN cord-335975-m6lkrehi 1754 8 of of IN cord-335975-m6lkrehi 1754 9 thiamine thiamine NN cord-335975-m6lkrehi 1754 10 derivatives derivative NNS cord-335975-m6lkrehi 1754 11 and and CC cord-335975-m6lkrehi 1754 12 arterial arterial JJ cord-335975-m6lkrehi 1754 13 lactate lactate NN cord-335975-m6lkrehi 1754 14 levels level NNS cord-335975-m6lkrehi 1754 15 in in IN cord-335975-m6lkrehi 1754 16 the the DT cord-335975-m6lkrehi 1754 17 subgroup subgroup NN cord-335975-m6lkrehi 1754 18 of of IN cord-335975-m6lkrehi 1754 19 patients patient NNS cord-335975-m6lkrehi 1754 20 exhibiting exhibit VBG cord-335975-m6lkrehi 1754 21 the the DT cord-335975-m6lkrehi 1754 22 highest high JJS cord-335975-m6lkrehi 1754 23 levels level NNS cord-335975-m6lkrehi 1754 24 of of IN cord-335975-m6lkrehi 1754 25 lactate lactate NN cord-335975-m6lkrehi 1754 26 ( ( -LRB- cord-335975-m6lkrehi 1754 27 > > XX cord-335975-m6lkrehi 1755 1 2 2 CD cord-335975-m6lkrehi 1755 2 and and CC cord-335975-m6lkrehi 1755 3 > > XX cord-335975-m6lkrehi 1755 4 4 4 CD cord-335975-m6lkrehi 1755 5 mmol mmol NNP cord-335975-m6lkrehi 1755 6 / / SYM cord-335975-m6lkrehi 1755 7 L L NNP cord-335975-m6lkrehi 1755 8 ) ) -RRB- cord-335975-m6lkrehi 1755 9 . . . cord-335975-m6lkrehi 1756 1 Total total JJ cord-335975-m6lkrehi 1756 2 thiamine thiamine NN cord-335975-m6lkrehi 1756 3 and and CC cord-335975-m6lkrehi 1756 4 TDP TDP NNP cord-335975-m6lkrehi 1756 5 concentration concentration NN cord-335975-m6lkrehi 1756 6 at at IN cord-335975-m6lkrehi 1756 7 the the DT cord-335975-m6lkrehi 1756 8 time time NN cord-335975-m6lkrehi 1756 9 of of IN cord-335975-m6lkrehi 1756 10 admission admission NN cord-335975-m6lkrehi 1756 11 were be VBD cord-335975-m6lkrehi 1756 12 significantly significantly RB cord-335975-m6lkrehi 1756 13 higher high JJR cord-335975-m6lkrehi 1756 14 in in IN cord-335975-m6lkrehi 1756 15 ICU ICU NNP cord-335975-m6lkrehi 1756 16 survivors survivor NNS cord-335975-m6lkrehi 1756 17 than than IN cord-335975-m6lkrehi 1756 18 in in IN cord-335975-m6lkrehi 1756 19 non non NNS cord-335975-m6lkrehi 1756 20 - - NNS cord-335975-m6lkrehi 1756 21 survivors survivor NNS cord-335975-m6lkrehi 1756 22 ( ( -LRB- cord-335975-m6lkrehi 1756 23 p p NN cord-335975-m6lkrehi 1756 24 = = SYM cord-335975-m6lkrehi 1756 25 0.031 0.031 CD cord-335975-m6lkrehi 1756 26 and and CC cord-335975-m6lkrehi 1756 27 p p NN cord-335975-m6lkrehi 1756 28 = = SYM cord-335975-m6lkrehi 1756 29 0.028 0.028 CD cord-335975-m6lkrehi 1756 30 ) ) -RRB- cord-335975-m6lkrehi 1756 31 . . . cord-335975-m6lkrehi 1757 1 During during IN cord-335975-m6lkrehi 1757 2 sepsis sepsis NN cord-335975-m6lkrehi 1757 3 , , , cord-335975-m6lkrehi 1757 4 we -PRON- PRP cord-335975-m6lkrehi 1757 5 did do VBD cord-335975-m6lkrehi 1757 6 not not RB cord-335975-m6lkrehi 1757 7 find find VB cord-335975-m6lkrehi 1757 8 any any DT cord-335975-m6lkrehi 1757 9 correlation correlation NN cord-335975-m6lkrehi 1757 10 between between IN cord-335975-m6lkrehi 1757 11 thiamine thiamine NN cord-335975-m6lkrehi 1757 12 and and CC cord-335975-m6lkrehi 1757 13 lactate lactate NN cord-335975-m6lkrehi 1757 14 concentration concentration NN cord-335975-m6lkrehi 1757 15 . . . cord-335975-m6lkrehi 1758 1 Lower low JJR cord-335975-m6lkrehi 1758 2 thiamine thiamine NN cord-335975-m6lkrehi 1758 3 diphosphate diphosphate JJ cord-335975-m6lkrehi 1758 4 concentration concentration NN cord-335975-m6lkrehi 1758 5 may may MD cord-335975-m6lkrehi 1758 6 be be VB cord-335975-m6lkrehi 1758 7 associated associate VBN cord-335975-m6lkrehi 1758 8 with with IN cord-335975-m6lkrehi 1758 9 ICU ICU NNP cord-335975-m6lkrehi 1758 10 - - HYPH cord-335975-m6lkrehi 1758 11 mortality mortality NN cord-335975-m6lkrehi 1758 12 . . . cord-335975-m6lkrehi 1759 1 Introduction introduction NN cord-335975-m6lkrehi 1759 2 : : : cord-335975-m6lkrehi 1760 1 A a DT cord-335975-m6lkrehi 1760 2 positive positive JJ cord-335975-m6lkrehi 1760 3 fluid fluid JJ cord-335975-m6lkrehi 1760 4 balance balance NN cord-335975-m6lkrehi 1760 5 in in IN cord-335975-m6lkrehi 1760 6 sepsis sepsis NN cord-335975-m6lkrehi 1760 7 is be VBZ cord-335975-m6lkrehi 1760 8 a a DT cord-335975-m6lkrehi 1760 9 determining determine VBG cord-335975-m6lkrehi 1760 10 factor factor NN cord-335975-m6lkrehi 1760 11 for for IN cord-335975-m6lkrehi 1760 12 mortality mortality NN cord-335975-m6lkrehi 1760 13 . . . cord-335975-m6lkrehi 1761 1 In in IN cord-335975-m6lkrehi 1761 2 previous previous JJ cord-335975-m6lkrehi 1761 3 experimental experimental JJ cord-335975-m6lkrehi 1761 4 studies study NNS cord-335975-m6lkrehi 1761 5 , , , cord-335975-m6lkrehi 1761 6 sodium sodium NN cord-335975-m6lkrehi 1761 7 lactate lactate NN cord-335975-m6lkrehi 1761 8 has have VBZ cord-335975-m6lkrehi 1761 9 been be VBN cord-335975-m6lkrehi 1761 10 shown show VBN cord-335975-m6lkrehi 1761 11 to to TO cord-335975-m6lkrehi 1761 12 improve improve VB cord-335975-m6lkrehi 1761 13 hemodynamic hemodynamic JJ cord-335975-m6lkrehi 1761 14 and and CC cord-335975-m6lkrehi 1761 15 avoid avoid VB cord-335975-m6lkrehi 1761 16 fluid fluid JJ cord-335975-m6lkrehi 1761 17 overload overload NN cord-335975-m6lkrehi 1761 18 ( ( -LRB- cord-335975-m6lkrehi 1761 19 1 1 CD cord-335975-m6lkrehi 1761 20 ) ) -RRB- cord-335975-m6lkrehi 1761 21 . . . cord-335975-m6lkrehi 1762 1 To to TO cord-335975-m6lkrehi 1762 2 understand understand VB cord-335975-m6lkrehi 1762 3 these these DT cord-335975-m6lkrehi 1762 4 beneficial beneficial JJ cord-335975-m6lkrehi 1762 5 effects effect NNS cord-335975-m6lkrehi 1762 6 , , , cord-335975-m6lkrehi 1762 7 we -PRON- PRP cord-335975-m6lkrehi 1762 8 investigated investigate VBD cord-335975-m6lkrehi 1762 9 the the DT cord-335975-m6lkrehi 1762 10 impact impact NN cord-335975-m6lkrehi 1762 11 of of IN cord-335975-m6lkrehi 1762 12 sodium sodium NN cord-335975-m6lkrehi 1762 13 lactate lactate NN cord-335975-m6lkrehi 1762 14 on on IN cord-335975-m6lkrehi 1762 15 capillary capillary JJ cord-335975-m6lkrehi 1762 16 leakage leakage NN cord-335975-m6lkrehi 1762 17 , , , cord-335975-m6lkrehi 1762 18 in in IN cord-335975-m6lkrehi 1762 19 comparaison comparaison NNP cord-335975-m6lkrehi 1762 20 to to TO cord-335975-m6lkrehi 1762 21 saline saline VB cord-335975-m6lkrehi 1762 22 on on IN cord-335975-m6lkrehi 1762 23 capillary capillary JJ cord-335975-m6lkrehi 1762 24 leak leak NN cord-335975-m6lkrehi 1762 25 in in IN cord-335975-m6lkrehi 1762 26 a a DT cord-335975-m6lkrehi 1762 27 rat rat NN cord-335975-m6lkrehi 1762 28 model model NN cord-335975-m6lkrehi 1762 29 . . . cord-335975-m6lkrehi 1763 1 The the DT cord-335975-m6lkrehi 1763 2 sixteen sixteen CD cord-335975-m6lkrehi 1763 3 sedated sedate VBN cord-335975-m6lkrehi 1763 4 , , , cord-335975-m6lkrehi 1763 5 mechanically mechanically RB cord-335975-m6lkrehi 1763 6 ventilated ventilate VBN cord-335975-m6lkrehi 1763 7 rats rat NNS cord-335975-m6lkrehi 1763 8 were be VBD cord-335975-m6lkrehi 1763 9 challenged challenge VBN cord-335975-m6lkrehi 1763 10 with with IN cord-335975-m6lkrehi 1763 11 intravenous intravenous JJ cord-335975-m6lkrehi 1763 12 infusion infusion NN cord-335975-m6lkrehi 1763 13 of of IN cord-335975-m6lkrehi 1763 14 E.coli E.coli NNS cord-335975-m6lkrehi 1763 15 lipopolysaccharide lipopolysaccharide NN cord-335975-m6lkrehi 1763 16 ( ( -LRB- cord-335975-m6lkrehi 1763 17 10 10 CD cord-335975-m6lkrehi 1763 18 mg mg NNP cord-335975-m6lkrehi 1763 19 / / SYM cord-335975-m6lkrehi 1763 20 kg kg NNP cord-335975-m6lkrehi 1763 21 ) ) -RRB- cord-335975-m6lkrehi 1763 22 . . . cord-335975-m6lkrehi 1764 1 Two two CD cord-335975-m6lkrehi 1764 2 groups group NNS cord-335975-m6lkrehi 1764 3 of of IN cord-335975-m6lkrehi 1764 4 eight eight CD cord-335975-m6lkrehi 1764 5 animals animal NNS cord-335975-m6lkrehi 1764 6 were be VBD cord-335975-m6lkrehi 1764 7 randomised randomised JJ cord-335975-m6lkrehi 1764 8 to to TO cord-335975-m6lkrehi 1764 9 receive receive VB cord-335975-m6lkrehi 1764 10 a a DT cord-335975-m6lkrehi 1764 11 continous continous JJ cord-335975-m6lkrehi 1764 12 perfusion perfusion NN cord-335975-m6lkrehi 1764 13 ( ( -LRB- cord-335975-m6lkrehi 1764 14 5 5 CD cord-335975-m6lkrehi 1764 15 mL ml NN cord-335975-m6lkrehi 1764 16 / / SYM cord-335975-m6lkrehi 1764 17 kg kg NN cord-335975-m6lkrehi 1764 18 / / SYM cord-335975-m6lkrehi 1764 19 h h NN cord-335975-m6lkrehi 1764 20 ) ) -RRB- cord-335975-m6lkrehi 1764 21 of of IN cord-335975-m6lkrehi 1764 22 sodium sodium NN cord-335975-m6lkrehi 1764 23 lactate lactate NN cord-335975-m6lkrehi 1764 24 11.2 11.2 CD cord-335975-m6lkrehi 1764 25 % % NN cord-335975-m6lkrehi 1764 26 ( ( -LRB- cord-335975-m6lkrehi 1764 27 treatment treatment NN cord-335975-m6lkrehi 1764 28 group group NN cord-335975-m6lkrehi 1764 29 ) ) -RRB- cord-335975-m6lkrehi 1764 30 or or CC cord-335975-m6lkrehi 1764 31 0.9 0.9 CD cord-335975-m6lkrehi 1764 32 % % NN cord-335975-m6lkrehi 1764 33 NaCl nacl NN cord-335975-m6lkrehi 1764 34 ( ( -LRB- cord-335975-m6lkrehi 1764 35 control control NN cord-335975-m6lkrehi 1764 36 group group NN cord-335975-m6lkrehi 1764 37 ) ) -RRB- cord-335975-m6lkrehi 1764 38 . . . cord-335975-m6lkrehi 1765 1 In in IN cord-335975-m6lkrehi 1765 2 order order NN cord-335975-m6lkrehi 1765 3 to to TO cord-335975-m6lkrehi 1765 4 inject inject VB cord-335975-m6lkrehi 1765 5 the the DT cord-335975-m6lkrehi 1765 6 same same JJ cord-335975-m6lkrehi 1765 7 caloric caloric JJ cord-335975-m6lkrehi 1765 8 load load NN cord-335975-m6lkrehi 1765 9 in in IN cord-335975-m6lkrehi 1765 10 the the DT cord-335975-m6lkrehi 1765 11 two two CD cord-335975-m6lkrehi 1765 12 groups group NNS cord-335975-m6lkrehi 1765 13 , , , cord-335975-m6lkrehi 1765 14 a a DT cord-335975-m6lkrehi 1765 15 4.35 4.35 CD cord-335975-m6lkrehi 1765 16 mL ml NN cord-335975-m6lkrehi 1765 17 / / SYM cord-335975-m6lkrehi 1765 18 kg kg NN cord-335975-m6lkrehi 1765 19 / / SYM cord-335975-m6lkrehi 1765 20 h h NN cord-335975-m6lkrehi 1765 21 of of IN cord-335975-m6lkrehi 1765 22 either either DT cord-335975-m6lkrehi 1765 23 water water NN cord-335975-m6lkrehi 1765 24 of of IN cord-335975-m6lkrehi 1765 25 10 10 CD cord-335975-m6lkrehi 1765 26 % % NN cord-335975-m6lkrehi 1765 27 dextrose dextrose NN cord-335975-m6lkrehi 1765 28 solution solution NN cord-335975-m6lkrehi 1765 29 were be VBD cord-335975-m6lkrehi 1765 30 perfused perfuse VBN cord-335975-m6lkrehi 1765 31 . . . cord-335975-m6lkrehi 1766 1 Mean mean JJ cord-335975-m6lkrehi 1766 2 arterial arterial JJ cord-335975-m6lkrehi 1766 3 pressure pressure NN cord-335975-m6lkrehi 1766 4 , , , cord-335975-m6lkrehi 1766 5 heart heart NN cord-335975-m6lkrehi 1766 6 rate rate NN cord-335975-m6lkrehi 1766 7 , , , cord-335975-m6lkrehi 1766 8 urine urine NN cord-335975-m6lkrehi 1766 9 ouput ouput NN cord-335975-m6lkrehi 1766 10 were be VBD cord-335975-m6lkrehi 1766 11 measured measure VBN cord-335975-m6lkrehi 1766 12 over over IN cord-335975-m6lkrehi 1766 13 a a DT cord-335975-m6lkrehi 1766 14 210 210 CD cord-335975-m6lkrehi 1766 15 min min NN cord-335975-m6lkrehi 1766 16 period period NN cord-335975-m6lkrehi 1766 17 . . . cord-335975-m6lkrehi 1767 1 An an DT cord-335975-m6lkrehi 1767 2 echocardiography echocardiography NN cord-335975-m6lkrehi 1767 3 was be VBD cord-335975-m6lkrehi 1767 4 then then RB cord-335975-m6lkrehi 1767 5 performed perform VBN cord-335975-m6lkrehi 1767 6 and and CC cord-335975-m6lkrehi 1767 7 Evans Evans NNP cord-335975-m6lkrehi 1767 8 Blue Blue NNP cord-335975-m6lkrehi 1767 9 ( ( -LRB- cord-335975-m6lkrehi 1767 10 1 1 CD cord-335975-m6lkrehi 1767 11 % % NN cord-335975-m6lkrehi 1767 12 , , , cord-335975-m6lkrehi 1767 13 30 30 CD cord-335975-m6lkrehi 1767 14 mg mg NN cord-335975-m6lkrehi 1767 15 / / SYM cord-335975-m6lkrehi 1767 16 kg kg NNP cord-335975-m6lkrehi 1767 17 ) ) -RRB- cord-335975-m6lkrehi 1767 18 was be VBD cord-335975-m6lkrehi 1767 19 intravenously intravenously RB cord-335975-m6lkrehi 1767 20 injected inject VBN cord-335975-m6lkrehi 1767 21 30 30 CD cord-335975-m6lkrehi 1767 22 min min NN cord-335975-m6lkrehi 1767 23 before before IN cord-335975-m6lkrehi 1767 24 sacrifice sacrifice NN cord-335975-m6lkrehi 1767 25 . . . cord-335975-m6lkrehi 1768 1 Organs organ NNS cord-335975-m6lkrehi 1768 2 were be VBD cord-335975-m6lkrehi 1768 3 withdrawn withdraw VBN cord-335975-m6lkrehi 1768 4 and and CC cord-335975-m6lkrehi 1768 5 organs organ NNS cord-335975-m6lkrehi 1768 6 wet wet JJ cord-335975-m6lkrehi 1768 7 dry dry JJ cord-335975-m6lkrehi 1768 8 ratio ratio NN cord-335975-m6lkrehi 1768 9 and and CC cord-335975-m6lkrehi 1768 10 Evans Evans NNP cord-335975-m6lkrehi 1768 11 blue blue JJ cord-335975-m6lkrehi 1768 12 dye dye NN cord-335975-m6lkrehi 1768 13 extravasation extravasation NN cord-335975-m6lkrehi 1768 14 were be VBD cord-335975-m6lkrehi 1768 15 measured measure VBN cord-335975-m6lkrehi 1768 16 . . . cord-335975-m6lkrehi 1769 1 Results result NNS cord-335975-m6lkrehi 1769 2 : : : cord-335975-m6lkrehi 1769 3 Fluid fluid JJ cord-335975-m6lkrehi 1769 4 balance balance NN cord-335975-m6lkrehi 1769 5 , , , cord-335975-m6lkrehi 1769 6 organs organ NNS cord-335975-m6lkrehi 1769 7 wet wet JJ cord-335975-m6lkrehi 1769 8 dry dry JJ cord-335975-m6lkrehi 1769 9 ratio ratio NN cord-335975-m6lkrehi 1769 10 and and CC cord-335975-m6lkrehi 1769 11 Evans Evans NNP cord-335975-m6lkrehi 1769 12 blue blue JJ cord-335975-m6lkrehi 1769 13 dye dye NN cord-335975-m6lkrehi 1769 14 extravasation extravasation NN cord-335975-m6lkrehi 1770 1 were be VBD cord-335975-m6lkrehi 1770 2 not not RB cord-335975-m6lkrehi 1770 3 significantly significantly RB cord-335975-m6lkrehi 1770 4 improved improve VBN cord-335975-m6lkrehi 1770 5 in in IN cord-335975-m6lkrehi 1770 6 sodium sodium NN cord-335975-m6lkrehi 1770 7 lactate lactate NN cord-335975-m6lkrehi 1770 8 group group NN cord-335975-m6lkrehi 1770 9 . . . cord-335975-m6lkrehi 1771 1 Hemodynamics hemodynamics NN cord-335975-m6lkrehi 1771 2 parameters parameter NNS cord-335975-m6lkrehi 1771 3 were be VBD cord-335975-m6lkrehi 1771 4 not not RB cord-335975-m6lkrehi 1771 5 significantly significantly RB cord-335975-m6lkrehi 1771 6 enhanced enhance VBN cord-335975-m6lkrehi 1771 7 after after IN cord-335975-m6lkrehi 1771 8 sodium sodium NN cord-335975-m6lkrehi 1771 9 lactate lactate NN cord-335975-m6lkrehi 1771 10 infusion infusion NN cord-335975-m6lkrehi 1771 11 . . . cord-335975-m6lkrehi 1772 1 Discussion discussion NN cord-335975-m6lkrehi 1772 2 : : : cord-335975-m6lkrehi 1773 1 Previously previously RB cord-335975-m6lkrehi 1773 2 , , , cord-335975-m6lkrehi 1773 3 lactate lactate NNP cord-335975-m6lkrehi 1773 4 administration administration NN cord-335975-m6lkrehi 1773 5 has have VBZ cord-335975-m6lkrehi 1773 6 improves improve VBZ cord-335975-m6lkrehi 1773 7 renal renal JJ cord-335975-m6lkrehi 1773 8 perfusion perfusion NN cord-335975-m6lkrehi 1773 9 . . . cord-335975-m6lkrehi 1774 1 In in IN cord-335975-m6lkrehi 1774 2 our -PRON- PRP$ cord-335975-m6lkrehi 1774 3 study study NN cord-335975-m6lkrehi 1774 4 , , , cord-335975-m6lkrehi 1774 5 the the DT cord-335975-m6lkrehi 1774 6 volume volume NN cord-335975-m6lkrehi 1774 7 of of IN cord-335975-m6lkrehi 1774 8 urine urine NN cord-335975-m6lkrehi 1774 9 output output NN cord-335975-m6lkrehi 1774 10 was be VBD cord-335975-m6lkrehi 1774 11 decreased decrease VBN cord-335975-m6lkrehi 1774 12 in in IN cord-335975-m6lkrehi 1774 13 the the DT cord-335975-m6lkrehi 1774 14 2 2 CD cord-335975-m6lkrehi 1774 15 groups group NNS cord-335975-m6lkrehi 1774 16 reflecting reflect VBG cord-335975-m6lkrehi 1774 17 the the DT cord-335975-m6lkrehi 1774 18 severity severity NN cord-335975-m6lkrehi 1774 19 of of IN cord-335975-m6lkrehi 1774 20 our -PRON- PRP$ cord-335975-m6lkrehi 1774 21 model model NN cord-335975-m6lkrehi 1774 22 . . . cord-335975-m6lkrehi 1775 1 and and CC cord-335975-m6lkrehi 1775 2 the the DT cord-335975-m6lkrehi 1775 3 vascular vascular JJ cord-335975-m6lkrehi 1775 4 filling filling NN cord-335975-m6lkrehi 1775 5 ( ( -LRB- cord-335975-m6lkrehi 1775 6 9.35 9.35 CD cord-335975-m6lkrehi 1775 7 ml ml NNS cord-335975-m6lkrehi 1775 8 / / SYM cord-335975-m6lkrehi 1775 9 kg kg NNP cord-335975-m6lkrehi 1775 10 / / SYM cord-335975-m6lkrehi 1775 11 h h NN cord-335975-m6lkrehi 1775 12 ) ) -RRB- cord-335975-m6lkrehi 1775 13 higher high JJR cord-335975-m6lkrehi 1775 14 than than IN cord-335975-m6lkrehi 1775 15 in in IN cord-335975-m6lkrehi 1775 16 the the DT cord-335975-m6lkrehi 1775 17 literature literature NN cord-335975-m6lkrehi 1775 18 could could MD cord-335975-m6lkrehi 1775 19 impact impact VB cord-335975-m6lkrehi 1775 20 our -PRON- PRP$ cord-335975-m6lkrehi 1775 21 results result NNS cord-335975-m6lkrehi 1775 22 . . . cord-335975-m6lkrehi 1776 1 ( ( -LRB- cord-335975-m6lkrehi 1776 2 1 1 CD cord-335975-m6lkrehi 1776 3 ) ) -RRB- cord-335975-m6lkrehi 1777 1 Recently recently RB cord-335975-m6lkrehi 1777 2 , , , cord-335975-m6lkrehi 1777 3 the the DT cord-335975-m6lkrehi 1777 4 pressure pressure NN cord-335975-m6lkrehi 1777 5 Electricy Electricy NNP cord-335975-m6lkrehi 1777 6 index index NN cord-335975-m6lkrehi 1777 7 - - : cord-335975-m6lkrehi 1777 8 Pmus Pmus NNP cord-335975-m6lkrehi 1777 9 Eadi Eadi NNP cord-335975-m6lkrehi 1777 10 index index NN cord-335975-m6lkrehi 1777 11 ( ( -LRB- cord-335975-m6lkrehi 1777 12 PEI PEI NNP cord-335975-m6lkrehi 1777 13 ) ) -RRB- cord-335975-m6lkrehi 1777 14 has have VBZ cord-335975-m6lkrehi 1777 15 been be VBN cord-335975-m6lkrehi 1777 16 described describe VBN cord-335975-m6lkrehi 1777 17 . . . cord-335975-m6lkrehi 1778 1 ( ( -LRB- cord-335975-m6lkrehi 1778 2 2 2 LS cord-335975-m6lkrehi 1778 3 ) ) -RRB- cord-335975-m6lkrehi 1779 1 The the DT cord-335975-m6lkrehi 1779 2 purpose purpose NN cord-335975-m6lkrehi 1779 3 of of IN cord-335975-m6lkrehi 1779 4 this this DT cord-335975-m6lkrehi 1779 5 study study NN cord-335975-m6lkrehi 1779 6 was be VBD cord-335975-m6lkrehi 1779 7 to to TO cord-335975-m6lkrehi 1779 8 assess assess VB cord-335975-m6lkrehi 1779 9 muscular muscular JJ cord-335975-m6lkrehi 1779 10 pressure pressure NN cord-335975-m6lkrehi 1779 11 ( ( -LRB- cord-335975-m6lkrehi 1779 12 Pmus Pmus NNP cord-335975-m6lkrehi 1779 13 ) ) -RRB- cord-335975-m6lkrehi 1779 14 using use VBG cord-335975-m6lkrehi 1779 15 PEI PEI NNP cord-335975-m6lkrehi 1779 16 with with IN cord-335975-m6lkrehi 1779 17 our -PRON- PRP$ cord-335975-m6lkrehi 1779 18 NAVA NAVA NNP cord-335975-m6lkrehi 1779 19 protocol protocol NN cord-335975-m6lkrehi 1779 20 . . . cord-335975-m6lkrehi 1780 1 Patients patient NNS cord-335975-m6lkrehi 1780 2 and and CC cord-335975-m6lkrehi 1780 3 methods method NNS cord-335975-m6lkrehi 1780 4 : : : cord-335975-m6lkrehi 1780 5 Observational observational JJ cord-335975-m6lkrehi 1780 6 study study NN cord-335975-m6lkrehi 1780 7 , , , cord-335975-m6lkrehi 1780 8 patients patient NNS cord-335975-m6lkrehi 1780 9 recovering recover VBG cord-335975-m6lkrehi 1780 10 from from IN cord-335975-m6lkrehi 1780 11 pneumonitis pneumonitis NN cord-335975-m6lkrehi 1780 12 and and CC cord-335975-m6lkrehi 1780 13 acute acute JJ cord-335975-m6lkrehi 1780 14 respiratory respiratory JJ cord-335975-m6lkrehi 1780 15 failure failure NN cord-335975-m6lkrehi 1780 16 . . . cord-335975-m6lkrehi 1781 1 SBT SBT NNP cord-335975-m6lkrehi 1781 2 was be VBD cord-335975-m6lkrehi 1781 3 Pressure Pressure NNP cord-335975-m6lkrehi 1781 4 Support Support NNP cord-335975-m6lkrehi 1781 5 Ventilation Ventilation NNP cord-335975-m6lkrehi 1781 6 with with IN cord-335975-m6lkrehi 1781 7 7cmH20 7cmh20 CD cord-335975-m6lkrehi 1781 8 of of IN cord-335975-m6lkrehi 1781 9 assist assist NN cord-335975-m6lkrehi 1781 10 and and CC cord-335975-m6lkrehi 1781 11 no no DT cord-335975-m6lkrehi 1781 12 PEP pep NN cord-335975-m6lkrehi 1781 13 . . . cord-335975-m6lkrehi 1782 1 PEI PEI NNP cord-335975-m6lkrehi 1782 2 was be VBD cord-335975-m6lkrehi 1782 3 calculated calculate VBN cord-335975-m6lkrehi 1782 4 under under IN cord-335975-m6lkrehi 1782 5 NAVA NAVA NNP cord-335975-m6lkrehi 1782 6 and and CC cord-335975-m6lkrehi 1782 7 during during IN cord-335975-m6lkrehi 1782 8 SBT SBT NNP cord-335975-m6lkrehi 1782 9 from from IN cord-335975-m6lkrehi 1782 10 airway airway JJ cord-335975-m6lkrehi 1782 11 pressure pressure NN cord-335975-m6lkrehi 1782 12 drop drop NN cord-335975-m6lkrehi 1782 13 during during IN cord-335975-m6lkrehi 1782 14 end end NN cord-335975-m6lkrehi 1782 15 - - HYPH cord-335975-m6lkrehi 1782 16 expiratory expiratory NN cord-335975-m6lkrehi 1782 17 occlusions occlusion NNS cord-335975-m6lkrehi 1782 18 , , , cord-335975-m6lkrehi 1782 19 muscular muscular JJ cord-335975-m6lkrehi 1782 20 pressure pressure NN cord-335975-m6lkrehi 1782 21 ( ( -LRB- cord-335975-m6lkrehi 1782 22 Pmus Pmus NNP cord-335975-m6lkrehi 1782 23 ) ) -RRB- cord-335975-m6lkrehi 1782 24 was be VBD cord-335975-m6lkrehi 1782 25 estimated estimate VBN cord-335975-m6lkrehi 1782 26 from from IN cord-335975-m6lkrehi 1782 27 PEI PEI NNP cord-335975-m6lkrehi 1782 28 ( ( -LRB- cord-335975-m6lkrehi 1782 29 2 2 CD cord-335975-m6lkrehi 1782 30 ) ) -RRB- cord-335975-m6lkrehi 1782 31 . . . cord-335975-m6lkrehi 1783 1 Another another DT cord-335975-m6lkrehi 1783 2 index index NN cord-335975-m6lkrehi 1783 3 , , , cord-335975-m6lkrehi 1783 4 patient patient JJ cord-335975-m6lkrehi 1783 5 ventilator ventilator NNP cord-335975-m6lkrehi 1783 6 contribution contribution NN cord-335975-m6lkrehi 1783 7 index index NN cord-335975-m6lkrehi 1783 8 ( ( -LRB- cord-335975-m6lkrehi 1783 9 PVBC PVBC NNP cord-335975-m6lkrehi 1783 10 ) ) -RRB- cord-335975-m6lkrehi 1783 11 was be VBD cord-335975-m6lkrehi 1783 12 also also RB cord-335975-m6lkrehi 1783 13 measured measure VBN cord-335975-m6lkrehi 1783 14 using use VBG cord-335975-m6lkrehi 1783 15 the the DT cord-335975-m6lkrehi 1783 16 inspiratory inspiratory JJ cord-335975-m6lkrehi 1783 17 peak peak NN cord-335975-m6lkrehi 1783 18 of of IN cord-335975-m6lkrehi 1783 19 EAdi EAdi NNP cord-335975-m6lkrehi 1783 20 and and CC cord-335975-m6lkrehi 1783 21 Vt Vt NNP cord-335975-m6lkrehi 1783 22 ( ( -LRB- cord-335975-m6lkrehi 1783 23 inspiratory inspiratory JJ cord-335975-m6lkrehi 1783 24 ) ) -RRB- cord-335975-m6lkrehi 1783 25 during during IN cord-335975-m6lkrehi 1783 26 assisted assisted JJ cord-335975-m6lkrehi 1783 27 and and CC cord-335975-m6lkrehi 1783 28 non non JJ cord-335975-m6lkrehi 1783 29 - - JJ cord-335975-m6lkrehi 1783 30 assisted assisted JJ cord-335975-m6lkrehi 1783 31 breaths breath NNS cord-335975-m6lkrehi 1783 32 . . . cord-335975-m6lkrehi 1784 1 We -PRON- PRP cord-335975-m6lkrehi 1784 2 calculated calculate VBD cord-335975-m6lkrehi 1784 3 PVBC PVBC NNP cord-335975-m6lkrehi 1784 4 - - HYPH cord-335975-m6lkrehi 1784 5 squared squared JJ cord-335975-m6lkrehi 1784 6 because because IN cord-335975-m6lkrehi 1784 7 it -PRON- PRP cord-335975-m6lkrehi 1784 8 has have VBZ cord-335975-m6lkrehi 1784 9 been be VBN cord-335975-m6lkrehi 1784 10 shown show VBN cord-335975-m6lkrehi 1784 11 that that IN cord-335975-m6lkrehi 1784 12 it -PRON- PRP cord-335975-m6lkrehi 1784 13 is be VBZ cord-335975-m6lkrehi 1784 14 more more RBR cord-335975-m6lkrehi 1784 15 correlated correlate VBN cord-335975-m6lkrehi 1784 16 to to IN cord-335975-m6lkrehi 1784 17 Pmus Pmus NNP cord-335975-m6lkrehi 1784 18 Ptot Ptot NNP cord-335975-m6lkrehi 1784 19 . . . cord-335975-m6lkrehi 1785 1 Results result NNS cord-335975-m6lkrehi 1785 2 : : : cord-335975-m6lkrehi 1786 1 Results result NNS cord-335975-m6lkrehi 1786 2 are be VBP cord-335975-m6lkrehi 1786 3 summarized summarize VBN cord-335975-m6lkrehi 1786 4 in in IN cord-335975-m6lkrehi 1786 5 the the DT cord-335975-m6lkrehi 1786 6 Introduction introduction NN cord-335975-m6lkrehi 1786 7 : : : cord-335975-m6lkrehi 1786 8 In in IN cord-335975-m6lkrehi 1786 9 ICU ICU NNP cord-335975-m6lkrehi 1786 10 , , , cord-335975-m6lkrehi 1786 11 intubation intubation NN cord-335975-m6lkrehi 1786 12 is be VBZ cord-335975-m6lkrehi 1786 13 a a DT cord-335975-m6lkrehi 1786 14 high high JJ cord-335975-m6lkrehi 1786 15 risk risk NN cord-335975-m6lkrehi 1786 16 procedure procedure NN cord-335975-m6lkrehi 1786 17 associated associate VBN cord-335975-m6lkrehi 1786 18 with with IN cord-335975-m6lkrehi 1786 19 high high JJ cord-335975-m6lkrehi 1786 20 morbidity morbidity NN cord-335975-m6lkrehi 1786 21 . . . cord-335975-m6lkrehi 1787 1 Despite despite IN cord-335975-m6lkrehi 1787 2 procedure procedure NN cord-335975-m6lkrehi 1787 3 's 's POS cord-335975-m6lkrehi 1787 4 improvement improvement NN cord-335975-m6lkrehi 1787 5 with with IN cord-335975-m6lkrehi 1787 6 systematic systematic JJ cord-335975-m6lkrehi 1787 7 application application NN cord-335975-m6lkrehi 1787 8 of of IN cord-335975-m6lkrehi 1787 9 fluid fluid JJ cord-335975-m6lkrehi 1787 10 loading loading NN cord-335975-m6lkrehi 1787 11 , , , cord-335975-m6lkrehi 1787 12 early early JJ cord-335975-m6lkrehi 1787 13 use use NN cord-335975-m6lkrehi 1787 14 of of IN cord-335975-m6lkrehi 1787 15 vasopressors vasopressor NNS cord-335975-m6lkrehi 1787 16 and and CC cord-335975-m6lkrehi 1787 17 checklist checklist NN cord-335975-m6lkrehi 1787 18 use use NN cord-335975-m6lkrehi 1787 19 , , , cord-335975-m6lkrehi 1787 20 morbidity morbidity NN cord-335975-m6lkrehi 1787 21 remains remain VBZ cord-335975-m6lkrehi 1787 22 high high JJ cord-335975-m6lkrehi 1787 23 . . . cord-335975-m6lkrehi 1788 1 First first JJ cord-335975-m6lkrehi 1788 2 pass pass NN cord-335975-m6lkrehi 1788 3 success success NN cord-335975-m6lkrehi 1788 4 is be VBZ cord-335975-m6lkrehi 1788 5 strongly strongly RB cord-335975-m6lkrehi 1788 6 correlated correlate VBN cord-335975-m6lkrehi 1788 7 with with IN cord-335975-m6lkrehi 1788 8 adverse adverse JJ cord-335975-m6lkrehi 1788 9 event event NN cord-335975-m6lkrehi 1788 10 occurrence occurrence NN cord-335975-m6lkrehi 1788 11 . . . cord-335975-m6lkrehi 1789 1 A a DT cord-335975-m6lkrehi 1789 2 recent recent JJ cord-335975-m6lkrehi 1789 3 study study NN cord-335975-m6lkrehi 1789 4 by by IN cord-335975-m6lkrehi 1789 5 Semler Semler NNP cord-335975-m6lkrehi 1789 6 et et NNP cord-335975-m6lkrehi 1789 7 al al NNP cord-335975-m6lkrehi 1789 8 . . NNP cord-335975-m6lkrehi 1789 9 concluded conclude VBD cord-335975-m6lkrehi 1789 10 than than IN cord-335975-m6lkrehi 1789 11 " " `` cord-335975-m6lkrehi 1789 12 sniffing sniff VBG cord-335975-m6lkrehi 1789 13 " " '' cord-335975-m6lkrehi 1789 14 position position NN cord-335975-m6lkrehi 1789 15 is be VBZ cord-335975-m6lkrehi 1789 16 better well JJR cord-335975-m6lkrehi 1789 17 than than IN cord-335975-m6lkrehi 1789 18 " " `` cord-335975-m6lkrehi 1789 19 ramped ramp VBN cord-335975-m6lkrehi 1789 20 " " '' cord-335975-m6lkrehi 1789 21 position position NN cord-335975-m6lkrehi 1789 22 to to TO cord-335975-m6lkrehi 1789 23 increase increase VB cord-335975-m6lkrehi 1789 24 first first JJ cord-335975-m6lkrehi 1789 25 pass pass NN cord-335975-m6lkrehi 1789 26 success success NN cord-335975-m6lkrehi 1789 27 even even RB cord-335975-m6lkrehi 1789 28 the the DT cord-335975-m6lkrehi 1789 29 primary primary JJ cord-335975-m6lkrehi 1789 30 outcome outcome NN cord-335975-m6lkrehi 1789 31 prespecifiedpulse prespecifiedpulse NN cord-335975-m6lkrehi 1789 32 pressure pressure NN cord-335975-m6lkrehi 1789 33 saturation saturation NN cord-335975-m6lkrehi 1789 34 was be VBD cord-335975-m6lkrehi 1789 35 not not RB cord-335975-m6lkrehi 1789 36 different different JJ cord-335975-m6lkrehi 1789 37 between between IN cord-335975-m6lkrehi 1789 38 the the DT cord-335975-m6lkrehi 1789 39 two two CD cord-335975-m6lkrehi 1789 40 groups group NNS cord-335975-m6lkrehi 1789 41 . . . cord-335975-m6lkrehi 1790 1 We -PRON- PRP cord-335975-m6lkrehi 1790 2 conducted conduct VBD cord-335975-m6lkrehi 1790 3 a a DT cord-335975-m6lkrehi 1790 4 post post FW cord-335975-m6lkrehi 1790 5 hoc hoc FW cord-335975-m6lkrehi 1790 6 analysis analysis NN cord-335975-m6lkrehi 1790 7 of of IN cord-335975-m6lkrehi 1790 8 the the DT cord-335975-m6lkrehi 1790 9 randomized randomized JJ cord-335975-m6lkrehi 1790 10 clinical clinical JJ cord-335975-m6lkrehi 1790 11 trial trial NN cord-335975-m6lkrehi 1790 12 MacGrath MacGrath NNP cord-335975-m6lkrehi 1790 13 Mac Mac NNP cord-335975-m6lkrehi 1790 14 video video NN cord-335975-m6lkrehi 1790 15 laryngoscope laryngoscope NN cord-335975-m6lkrehi 1790 16 or or CC cord-335975-m6lkrehi 1790 17 Macintosh Macintosh NNP cord-335975-m6lkrehi 1790 18 laryngoscope laryngoscope NN cord-335975-m6lkrehi 1790 19 for for IN cord-335975-m6lkrehi 1790 20 intubation intubation NN cord-335975-m6lkrehi 1790 21 in in IN cord-335975-m6lkrehi 1790 22 the the DT cord-335975-m6lkrehi 1790 23 intensive intensive JJ cord-335975-m6lkrehi 1790 24 care care NN cord-335975-m6lkrehi 1790 25 unit unit NN cord-335975-m6lkrehi 1790 26 ( ( -LRB- cord-335975-m6lkrehi 1790 27 MACMAN MACMAN NNP cord-335975-m6lkrehi 1790 28 ) ) -RRB- cord-335975-m6lkrehi 1790 29 to to TO cord-335975-m6lkrehi 1790 30 determine determine VB cord-335975-m6lkrehi 1790 31 the the DT cord-335975-m6lkrehi 1790 32 best good JJS cord-335975-m6lkrehi 1790 33 position position NN cord-335975-m6lkrehi 1790 34 for for IN cord-335975-m6lkrehi 1790 35 intubation intubation NN cord-335975-m6lkrehi 1790 36 in in IN cord-335975-m6lkrehi 1790 37 the the DT cord-335975-m6lkrehi 1790 38 ICU ICU NNP cord-335975-m6lkrehi 1790 39 . . . cord-335975-m6lkrehi 1791 1 Patients patient NNS cord-335975-m6lkrehi 1791 2 and and CC cord-335975-m6lkrehi 1791 3 methods method NNS cord-335975-m6lkrehi 1791 4 : : : cord-335975-m6lkrehi 1791 5 MACMAN MACMAN NNP cord-335975-m6lkrehi 1791 6 was be VBD cord-335975-m6lkrehi 1791 7 a a DT cord-335975-m6lkrehi 1791 8 multicentre multicentre NN cord-335975-m6lkrehi 1791 9 , , , cord-335975-m6lkrehi 1791 10 open open JJ cord-335975-m6lkrehi 1791 11 - - HYPH cord-335975-m6lkrehi 1791 12 label label NN cord-335975-m6lkrehi 1791 13 , , , cord-335975-m6lkrehi 1791 14 randomized randomized JJ cord-335975-m6lkrehi 1791 15 controlled controlled JJ cord-335975-m6lkrehi 1791 16 superiority superiority NN cord-335975-m6lkrehi 1791 17 trial trial NN cord-335975-m6lkrehi 1791 18 . . . cord-335975-m6lkrehi 1792 1 Consecutive consecutive JJ cord-335975-m6lkrehi 1792 2 patients patient NNS cord-335975-m6lkrehi 1792 3 requiring require VBG cord-335975-m6lkrehi 1792 4 intubation intubation NN cord-335975-m6lkrehi 1792 5 were be VBD cord-335975-m6lkrehi 1792 6 randomly randomly RB cord-335975-m6lkrehi 1792 7 allocated allocate VBN cord-335975-m6lkrehi 1792 8 to to IN cord-335975-m6lkrehi 1792 9 either either CC cord-335975-m6lkrehi 1792 10 the the DT cord-335975-m6lkrehi 1792 11 McGRATH McGRATH NNP cord-335975-m6lkrehi 1792 12 MAC MAC NNP cord-335975-m6lkrehi 1792 13 videolaryngoscope videolaryngoscope NN cord-335975-m6lkrehi 1792 14 or or CC cord-335975-m6lkrehi 1792 15 the the DT cord-335975-m6lkrehi 1792 16 Macintosh Macintosh NNP cord-335975-m6lkrehi 1792 17 laryngoscope laryngoscope NN cord-335975-m6lkrehi 1792 18 , , , cord-335975-m6lkrehi 1792 19 with with IN cord-335975-m6lkrehi 1792 20 stratification stratification NN cord-335975-m6lkrehi 1792 21 by by IN cord-335975-m6lkrehi 1792 22 centre centre NN cord-335975-m6lkrehi 1792 23 and and CC cord-335975-m6lkrehi 1792 24 operator operator NN cord-335975-m6lkrehi 1792 25 experience experience NN cord-335975-m6lkrehi 1792 26 . . . cord-335975-m6lkrehi 1793 1 An an DT cord-335975-m6lkrehi 1793 2 only only JJ cord-335975-m6lkrehi 1793 3 inclusion inclusion NN cord-335975-m6lkrehi 1793 4 criterion criterion NN cord-335975-m6lkrehi 1793 5 was-"Patients was-"Patients NNP cord-335975-m6lkrehi 1793 6 must must MD cord-335975-m6lkrehi 1793 7 be be VB cord-335975-m6lkrehi 1793 8 admitted admit VBN cord-335975-m6lkrehi 1793 9 to to IN cord-335975-m6lkrehi 1793 10 an an DT cord-335975-m6lkrehi 1793 11 ICU ICU NNP cord-335975-m6lkrehi 1793 12 and and CC cord-335975-m6lkrehi 1793 13 require require VB cord-335975-m6lkrehi 1793 14 mechanical mechanical JJ cord-335975-m6lkrehi 1793 15 ventilation ventilation NN cord-335975-m6lkrehi 1793 16 through through IN cord-335975-m6lkrehi 1793 17 an an DT cord-335975-m6lkrehi 1793 18 endotracheal endotracheal NN cord-335975-m6lkrehi 1793 19 tube tube NN cord-335975-m6lkrehi 1793 20 " " '' cord-335975-m6lkrehi 1793 21 . . . cord-335975-m6lkrehi 1794 1 Patients patient NNS cord-335975-m6lkrehi 1794 2 were be VBD cord-335975-m6lkrehi 1794 3 excluded exclude VBN cord-335975-m6lkrehi 1794 4 if if IN cord-335975-m6lkrehi 1794 5 - - HYPH cord-335975-m6lkrehi 1794 6 contraindication contraindication NN cord-335975-m6lkrehi 1794 7 to to IN cord-335975-m6lkrehi 1794 8 orotracheal orotracheal JJ cord-335975-m6lkrehi 1794 9 intubation intubation NN cord-335975-m6lkrehi 1794 10 ( ( -LRB- cord-335975-m6lkrehi 1794 11 e.g. e.g. RB cord-335975-m6lkrehi 1794 12 , , , cord-335975-m6lkrehi 1794 13 unstable unstable JJ cord-335975-m6lkrehi 1794 14 spinal spinal JJ cord-335975-m6lkrehi 1794 15 lesion lesion NN cord-335975-m6lkrehi 1794 16 ) ) -RRB- cord-335975-m6lkrehi 1794 17 ; ; , cord-335975-m6lkrehi 1794 18 insufficient insufficient JJ cord-335975-m6lkrehi 1794 19 time time NN cord-335975-m6lkrehi 1794 20 to to TO cord-335975-m6lkrehi 1794 21 include include VB cord-335975-m6lkrehi 1794 22 and and CC cord-335975-m6lkrehi 1794 23 randomize randomize VB cord-335975-m6lkrehi 1794 24 the the DT cord-335975-m6lkrehi 1794 25 patient patient NN cord-335975-m6lkrehi 1794 26 ( ( -LRB- cord-335975-m6lkrehi 1794 27 e.g. e.g. RB cord-335975-m6lkrehi 1794 28 , , , cord-335975-m6lkrehi 1794 29 because because IN cord-335975-m6lkrehi 1794 30 of of IN cord-335975-m6lkrehi 1794 31 cardiac cardiac JJ cord-335975-m6lkrehi 1794 32 arrest arrest NN cord-335975-m6lkrehi 1794 33 ) ) -RRB- cord-335975-m6lkrehi 1794 34 ; ; : cord-335975-m6lkrehi 1794 35 age age NN cord-335975-m6lkrehi 1794 36 < < XX cord-335975-m6lkrehi 1794 37 18 18 CD cord-335975-m6lkrehi 1794 38 years year NNS cord-335975-m6lkrehi 1794 39 ; ; : cord-335975-m6lkrehi 1794 40 pregnant pregnant JJ cord-335975-m6lkrehi 1794 41 or or CC cord-335975-m6lkrehi 1794 42 breastfeeding breastfeed VBG cord-335975-m6lkrehi 1794 43 woman woman NN cord-335975-m6lkrehi 1794 44 + + CC cord-335975-m6lkrehi 1794 45 correctional correctional NNP cord-335975-m6lkrehi 1794 46 facility facility NN cord-335975-m6lkrehi 1794 47 inmate inmate NN cord-335975-m6lkrehi 1794 48 ; ; : cord-335975-m6lkrehi 1794 49 patient patient JJ cord-335975-m6lkrehi 1794 50 under under IN cord-335975-m6lkrehi 1794 51 guardianship guardianship NN cord-335975-m6lkrehi 1794 52 + + CC cord-335975-m6lkrehi 1794 53 patient patient NN cord-335975-m6lkrehi 1794 54 without without IN cord-335975-m6lkrehi 1794 55 health health NN cord-335975-m6lkrehi 1794 56 insurance insurance NN cord-335975-m6lkrehi 1794 57 ; ; : cord-335975-m6lkrehi 1794 58 refusal refusal NN cord-335975-m6lkrehi 1794 59 of of IN cord-335975-m6lkrehi 1794 60 the the DT cord-335975-m6lkrehi 1794 61 patient patient NN cord-335975-m6lkrehi 1794 62 or or CC cord-335975-m6lkrehi 1794 63 next next JJ cord-335975-m6lkrehi 1794 64 of of IN cord-335975-m6lkrehi 1794 65 kin kin NN cord-335975-m6lkrehi 1794 66 to to TO cord-335975-m6lkrehi 1794 67 participate participate VB cord-335975-m6lkrehi 1794 68 in in IN cord-335975-m6lkrehi 1794 69 the the DT cord-335975-m6lkrehi 1794 70 study study NN cord-335975-m6lkrehi 1794 71 ; ; : cord-335975-m6lkrehi 1794 72 previous previous JJ cord-335975-m6lkrehi 1794 73 enrolment enrolment NN cord-335975-m6lkrehi 1794 74 in in IN cord-335975-m6lkrehi 1794 75 a a DT cord-335975-m6lkrehi 1794 76 clinical clinical JJ cord-335975-m6lkrehi 1794 77 randomized randomized JJ cord-335975-m6lkrehi 1794 78 trial trial NN cord-335975-m6lkrehi 1794 79 with with IN cord-335975-m6lkrehi 1794 80 intubation intubation NN cord-335975-m6lkrehi 1794 81 as as IN cord-335975-m6lkrehi 1794 82 the the DT cord-335975-m6lkrehi 1794 83 primary primary JJ cord-335975-m6lkrehi 1794 84 end end NN cord-335975-m6lkrehi 1794 85 point point NN cord-335975-m6lkrehi 1794 86 ( ( -LRB- cord-335975-m6lkrehi 1794 87 including include VBG cord-335975-m6lkrehi 1794 88 previous previous JJ cord-335975-m6lkrehi 1794 89 inclusion inclusion NN cord-335975-m6lkrehi 1794 90 in in IN cord-335975-m6lkrehi 1794 91 the the DT cord-335975-m6lkrehi 1794 92 present present JJ cord-335975-m6lkrehi 1794 93 trial trial NN cord-335975-m6lkrehi 1794 94 ) ) -RRB- cord-335975-m6lkrehi 1794 95 . . . cord-335975-m6lkrehi 1795 1 Post post JJ cord-335975-m6lkrehi 1795 2 - - JJ cord-335975-m6lkrehi 1795 3 hoc hoc JJ cord-335975-m6lkrehi 1795 4 analysis analysis NN cord-335975-m6lkrehi 1795 5 was be VBD cord-335975-m6lkrehi 1795 6 performed perform VBN cord-335975-m6lkrehi 1795 7 to to TO cord-335975-m6lkrehi 1795 8 assess assess VB cord-335975-m6lkrehi 1795 9 association association NN cord-335975-m6lkrehi 1795 10 between between IN cord-335975-m6lkrehi 1795 11 patient patient NN cord-335975-m6lkrehi 1795 12 position position NN cord-335975-m6lkrehi 1795 13 ( ( -LRB- cord-335975-m6lkrehi 1795 14 sniffing sniff VBG cord-335975-m6lkrehi 1795 15 or or CC cord-335975-m6lkrehi 1795 16 supine supine JJ cord-335975-m6lkrehi 1795 17 ) ) -RRB- cord-335975-m6lkrehi 1795 18 and and CC cord-335975-m6lkrehi 1795 19 first first JJ cord-335975-m6lkrehi 1795 20 pass pass NN cord-335975-m6lkrehi 1795 21 success success NN cord-335975-m6lkrehi 1795 22 . . . cord-335975-m6lkrehi 1796 1 Between between IN cord-335975-m6lkrehi 1796 2 - - HYPH cord-335975-m6lkrehi 1796 3 groups group NNS cord-335975-m6lkrehi 1796 4 baseline baseline JJ cord-335975-m6lkrehi 1796 5 difference difference NN cord-335975-m6lkrehi 1796 6 was be VBD cord-335975-m6lkrehi 1796 7 adjusted adjust VBN cord-335975-m6lkrehi 1796 8 for for IN cord-335975-m6lkrehi 1796 9 baseline baseline JJ cord-335975-m6lkrehi 1796 10 covariates covariate NNS cord-335975-m6lkrehi 1796 11 significantly significantly RB cord-335975-m6lkrehi 1796 12 associated associate VBN cord-335975-m6lkrehi 1796 13 with with IN cord-335975-m6lkrehi 1796 14 the the DT cord-335975-m6lkrehi 1796 15 group group NN cord-335975-m6lkrehi 1796 16 membership membership NN cord-335975-m6lkrehi 1796 17 ( ( -LRB- cord-335975-m6lkrehi 1796 18 p p NN cord-335975-m6lkrehi 1796 19 < < XX cord-335975-m6lkrehi 1796 20 0.2 0.2 CD cord-335975-m6lkrehi 1796 21 ) ) -RRB- cord-335975-m6lkrehi 1796 22 . . . cord-335975-m6lkrehi 1797 1 Results result NNS cord-335975-m6lkrehi 1797 2 : : : cord-335975-m6lkrehi 1798 1 Failure failure NN cord-335975-m6lkrehi 1798 2 of of IN cord-335975-m6lkrehi 1798 3 first first JJ cord-335975-m6lkrehi 1798 4 pass pass NN cord-335975-m6lkrehi 1798 5 Introduction introduction NN cord-335975-m6lkrehi 1798 6 : : : cord-335975-m6lkrehi 1799 1 During during IN cord-335975-m6lkrehi 1799 2 acute acute JJ cord-335975-m6lkrehi 1799 3 exacerbation exacerbation NN cord-335975-m6lkrehi 1799 4 of of IN cord-335975-m6lkrehi 1799 5 COPD COPD NNP cord-335975-m6lkrehi 1799 6 oxygen oxygen NN cord-335975-m6lkrehi 1799 7 should should MD cord-335975-m6lkrehi 1799 8 be be VB cord-335975-m6lkrehi 1799 9 titrated titrate VBN cord-335975-m6lkrehi 1799 10 to to TO cord-335975-m6lkrehi 1799 11 avoid avoid VB cord-335975-m6lkrehi 1799 12 both both DT cord-335975-m6lkrehi 1799 13 hypoxemia hypoxemia NN cord-335975-m6lkrehi 1799 14 and and CC cord-335975-m6lkrehi 1799 15 hyperoxia hyperoxia NN cord-335975-m6lkrehi 1799 16 . . . cord-335975-m6lkrehi 1800 1 The the DT cord-335975-m6lkrehi 1800 2 recommendations recommendation NNS cord-335975-m6lkrehi 1800 3 are be VBP cord-335975-m6lkrehi 1800 4 not not RB cord-335975-m6lkrehi 1800 5 followed follow VBN cord-335975-m6lkrehi 1800 6 and and CC cord-335975-m6lkrehi 1800 7 automated automate VBN cord-335975-m6lkrehi 1800 8 oxygen oxygen NN cord-335975-m6lkrehi 1800 9 titration titration NN cord-335975-m6lkrehi 1800 10 may may MD cord-335975-m6lkrehi 1800 11 be be VB cord-335975-m6lkrehi 1800 12 useful useful JJ cord-335975-m6lkrehi 1800 13 in in IN cord-335975-m6lkrehi 1800 14 this this DT cord-335975-m6lkrehi 1800 15 population population NN cord-335975-m6lkrehi 1800 16 . . . cord-335975-m6lkrehi 1801 1 The the DT cord-335975-m6lkrehi 1801 2 aim aim NN cord-335975-m6lkrehi 1801 3 of of IN cord-335975-m6lkrehi 1801 4 this this DT cord-335975-m6lkrehi 1801 5 study study NN cord-335975-m6lkrehi 1801 6 was be VBD cord-335975-m6lkrehi 1801 7 to to TO cord-335975-m6lkrehi 1801 8 evaluate evaluate VB cord-335975-m6lkrehi 1801 9 a a DT cord-335975-m6lkrehi 1801 10 new new JJ cord-335975-m6lkrehi 1801 11 device device NN cord-335975-m6lkrehi 1801 12 developed develop VBN cord-335975-m6lkrehi 1801 13 to to TO cord-335975-m6lkrehi 1801 14 automatically automatically RB cord-335975-m6lkrehi 1801 15 titrate titrate VB cord-335975-m6lkrehi 1801 16 oxygen oxygen NN cord-335975-m6lkrehi 1801 17 based base VBN cord-335975-m6lkrehi 1801 18 on on IN cord-335975-m6lkrehi 1801 19 SpO2 SpO2 NNP cord-335975-m6lkrehi 1801 20 target target NN cord-335975-m6lkrehi 1801 21 ( ( -LRB- cord-335975-m6lkrehi 1801 22 FreeO2 freeo2 XX cord-335975-m6lkrehi 1801 23 , , , cord-335975-m6lkrehi 1801 24 Oxynov Oxynov NNP cord-335975-m6lkrehi 1801 25 , , , cord-335975-m6lkrehi 1801 26 Canada Canada NNP cord-335975-m6lkrehi 1801 27 ) ) -RRB- cord-335975-m6lkrehi 1801 28 and and CC cord-335975-m6lkrehi 1801 29 to to TO cord-335975-m6lkrehi 1801 30 compare compare VB cord-335975-m6lkrehi 1801 31 oxygenation oxygenation NN cord-335975-m6lkrehi 1801 32 parameters parameter NNS cord-335975-m6lkrehi 1801 33 with with IN cord-335975-m6lkrehi 1801 34 usual usual JJ cord-335975-m6lkrehi 1801 35 administration administration NN cord-335975-m6lkrehi 1801 36 ( ( -LRB- cord-335975-m6lkrehi 1801 37 manual manual JJ cord-335975-m6lkrehi 1801 38 flowmeter flowmeter NN cord-335975-m6lkrehi 1801 39 ) ) -RRB- cord-335975-m6lkrehi 1801 40 . . . cord-335975-m6lkrehi 1802 1 The the DT cord-335975-m6lkrehi 1802 2 study study NN cord-335975-m6lkrehi 1802 3 is be VBZ cord-335975-m6lkrehi 1802 4 an an DT cord-335975-m6lkrehi 1802 5 observational observational JJ cord-335975-m6lkrehi 1802 6 monocentric monocentric JJ cord-335975-m6lkrehi 1802 7 study study NN cord-335975-m6lkrehi 1802 8 . . . cord-335975-m6lkrehi 1803 1 We -PRON- PRP cord-335975-m6lkrehi 1803 2 prospectively prospectively RB cord-335975-m6lkrehi 1803 3 included include VBD cord-335975-m6lkrehi 1803 4 patients patient NNS cord-335975-m6lkrehi 1803 5 hospitalized hospitalize VBN cord-335975-m6lkrehi 1803 6 for for IN cord-335975-m6lkrehi 1803 7 acute acute JJ cord-335975-m6lkrehi 1803 8 exacerbation exacerbation NN cord-335975-m6lkrehi 1803 9 of of IN cord-335975-m6lkrehi 1803 10 COPD COPD NNP cord-335975-m6lkrehi 1803 11 receiving receive VBG cord-335975-m6lkrehi 1803 12 oxygen oxygen NN cord-335975-m6lkrehi 1803 13 . . . cord-335975-m6lkrehi 1804 1 Written write VBN cord-335975-m6lkrehi 1804 2 informed informed JJ cord-335975-m6lkrehi 1804 3 consent consent NN cord-335975-m6lkrehi 1804 4 was be VBD cord-335975-m6lkrehi 1804 5 obtained obtain VBN cord-335975-m6lkrehi 1804 6 from from IN cord-335975-m6lkrehi 1804 7 all all DT cord-335975-m6lkrehi 1804 8 patient patient NN cord-335975-m6lkrehi 1804 9 . . . cord-335975-m6lkrehi 1805 1 In in IN cord-335975-m6lkrehi 1805 2 the the DT cord-335975-m6lkrehi 1805 3 first first JJ cord-335975-m6lkrehi 1805 4 part part NN cord-335975-m6lkrehi 1805 5 of of IN cord-335975-m6lkrehi 1805 6 the the DT cord-335975-m6lkrehi 1805 7 study study NN cord-335975-m6lkrehi 1805 8 , , , cord-335975-m6lkrehi 1805 9 we -PRON- PRP cord-335975-m6lkrehi 1805 10 evaluated evaluate VBD cord-335975-m6lkrehi 1805 11 oxygen oxygen NN cord-335975-m6lkrehi 1805 12 flowrate flowrate NN cord-335975-m6lkrehi 1805 13 and and CC cord-335975-m6lkrehi 1805 14 SpO2 SpO2 NNP cord-335975-m6lkrehi 1805 15 during during IN cord-335975-m6lkrehi 1805 16 30 30 CD cord-335975-m6lkrehi 1805 17 min min NN cord-335975-m6lkrehi 1805 18 at at IN cord-335975-m6lkrehi 1805 19 baseline baseline NN cord-335975-m6lkrehi 1805 20 based base VBN cord-335975-m6lkrehi 1805 21 on on IN cord-335975-m6lkrehi 1805 22 management management NN cord-335975-m6lkrehi 1805 23 of of IN cord-335975-m6lkrehi 1805 24 the the DT cord-335975-m6lkrehi 1805 25 physicians physician NNS cord-335975-m6lkrehi 1805 26 in in IN cord-335975-m6lkrehi 1805 27 charge charge NN cord-335975-m6lkrehi 1805 28 . . . cord-335975-m6lkrehi 1806 1 The the DT cord-335975-m6lkrehi 1806 2 oxygenation oxygenation NN cord-335975-m6lkrehi 1806 3 parameters parameter NNS cord-335975-m6lkrehi 1806 4 were be VBD cord-335975-m6lkrehi 1806 5 compared compare VBN cord-335975-m6lkrehi 1806 6 with with IN cord-335975-m6lkrehi 1806 7 automated automated JJ cord-335975-m6lkrehi 1806 8 titration titration NN cord-335975-m6lkrehi 1806 9 ( ( -LRB- cord-335975-m6lkrehi 1807 1 FreeO2 FreeO2 NNP cord-335975-m6lkrehi 1807 2 during during IN cord-335975-m6lkrehi 1807 3 1 1 CD cord-335975-m6lkrehi 1807 4 h h NN cord-335975-m6lkrehi 1807 5 ) ) -RRB- cord-335975-m6lkrehi 1807 6 . . . cord-335975-m6lkrehi 1808 1 In in IN cord-335975-m6lkrehi 1808 2 the the DT cord-335975-m6lkrehi 1808 3 second second JJ cord-335975-m6lkrehi 1808 4 part part NN cord-335975-m6lkrehi 1808 5 of of IN cord-335975-m6lkrehi 1808 6 the the DT cord-335975-m6lkrehi 1808 7 study study NN cord-335975-m6lkrehi 1808 8 , , , cord-335975-m6lkrehi 1808 9 oxygen oxygen NN cord-335975-m6lkrehi 1808 10 was be VBD cord-335975-m6lkrehi 1808 11 delivered deliver VBN cord-335975-m6lkrehi 1808 12 with with IN cord-335975-m6lkrehi 1808 13 FreeO2 freeo2 NN cord-335975-m6lkrehi 1808 14 until until IN cord-335975-m6lkrehi 1808 15 oxygen oxygen NN cord-335975-m6lkrehi 1808 16 weaning weaning NN cord-335975-m6lkrehi 1808 17 or or CC cord-335975-m6lkrehi 1808 18 a a DT cord-335975-m6lkrehi 1808 19 maximum maximum NN cord-335975-m6lkrehi 1808 20 of of IN cord-335975-m6lkrehi 1808 21 72 72 CD cord-335975-m6lkrehi 1808 22 h. h. NN cord-335975-m6lkrehi 1809 1 We -PRON- PRP cord-335975-m6lkrehi 1809 2 evaluated evaluate VBD cord-335975-m6lkrehi 1809 3 the the DT cord-335975-m6lkrehi 1809 4 oxygenation oxygenation NN cord-335975-m6lkrehi 1809 5 parameters parameter NNS cord-335975-m6lkrehi 1809 6 during during IN cord-335975-m6lkrehi 1809 7 prolonged prolonged JJ cord-335975-m6lkrehi 1809 8 utilization utilization NN cord-335975-m6lkrehi 1809 9 , , , cord-335975-m6lkrehi 1809 10 the the DT cord-335975-m6lkrehi 1809 11 duration duration NN cord-335975-m6lkrehi 1809 12 of of IN cord-335975-m6lkrehi 1809 13 oxygen oxygen NNP cord-335975-m6lkrehi 1809 14 administration administration NN cord-335975-m6lkrehi 1809 15 , , , cord-335975-m6lkrehi 1809 16 a a DT cord-335975-m6lkrehi 1809 17 new new JJ cord-335975-m6lkrehi 1809 18 Bluetooth Bluetooth NNP cord-335975-m6lkrehi 1809 19 SpO2 spo2 NN cord-335975-m6lkrehi 1809 20 connection connection NN cord-335975-m6lkrehi 1809 21 compared compare VBN cord-335975-m6lkrehi 1809 22 to to IN cord-335975-m6lkrehi 1809 23 wire wire NN cord-335975-m6lkrehi 1809 24 SpO2 SpO2 NNP cord-335975-m6lkrehi 1809 25 connection connection NN cord-335975-m6lkrehi 1809 26 ( ( -LRB- cord-335975-m6lkrehi 1809 27 evaluated evaluate VBN cord-335975-m6lkrehi 1809 28 by by IN cord-335975-m6lkrehi 1809 29 Visual Visual NNP cord-335975-m6lkrehi 1809 30 Analog Analog NNP cord-335975-m6lkrehi 1809 31 Scale Scale NNP cord-335975-m6lkrehi 1809 32 0 0 CD cord-335975-m6lkrehi 1809 33 - - SYM cord-335975-m6lkrehi 1809 34 10 10 CD cord-335975-m6lkrehi 1809 35 ) ) -RRB- cord-335975-m6lkrehi 1809 36 . . . cord-335975-m6lkrehi 1810 1 Results result NNS cord-335975-m6lkrehi 1810 2 : : : cord-335975-m6lkrehi 1811 1 We -PRON- PRP cord-335975-m6lkrehi 1811 2 present present VBP cord-335975-m6lkrehi 1811 3 preliminary preliminary JJ cord-335975-m6lkrehi 1811 4 data datum NNS cord-335975-m6lkrehi 1811 5 of of IN cord-335975-m6lkrehi 1811 6 23 23 CD cord-335975-m6lkrehi 1811 7 COPD COPD NNP cord-335975-m6lkrehi 1811 8 patients patient NNS cord-335975-m6lkrehi 1811 9 ( ( -LRB- cord-335975-m6lkrehi 1811 10 sex sex NN cord-335975-m6lkrehi 1811 11 ratio ratio NN cord-335975-m6lkrehi 1811 12 M M NNP cord-335975-m6lkrehi 1811 13 F F NNP cord-335975-m6lkrehi 1811 14 = = NN cord-335975-m6lkrehi 1811 15 9 9 CD cord-335975-m6lkrehi 1811 16 14 14 CD cord-335975-m6lkrehi 1811 17 ) ) -RRB- cord-335975-m6lkrehi 1811 18 . . . cord-335975-m6lkrehi 1812 1 Mean mean JJ cord-335975-m6lkrehi 1812 2 age age NN cord-335975-m6lkrehi 1812 3 ( ( -LRB- cord-335975-m6lkrehi 1812 4 ± ± NNP cord-335975-m6lkrehi 1812 5 SD SD NNP cord-335975-m6lkrehi 1812 6 ) ) -RRB- cord-335975-m6lkrehi 1812 7 was be VBD cord-335975-m6lkrehi 1812 8 72 72 CD cord-335975-m6lkrehi 1812 9 ± ± NNP cord-335975-m6lkrehi 1812 10 11 11 CD cord-335975-m6lkrehi 1812 11 years year NNS cord-335975-m6lkrehi 1812 12 , , , cord-335975-m6lkrehi 1812 13 mean mean VBP cord-335975-m6lkrehi 1812 14 FEV1 FEV1 NNP cord-335975-m6lkrehi 1812 15 ( ( -LRB- cord-335975-m6lkrehi 1812 16 ± ± NNP cord-335975-m6lkrehi 1812 17 SD SD NNP cord-335975-m6lkrehi 1812 18 ) ) -RRB- cord-335975-m6lkrehi 1812 19 was be VBD cord-335975-m6lkrehi 1812 20 0.9 0.9 CD cord-335975-m6lkrehi 1812 21 ± ± CD cord-335975-m6lkrehi 1812 22 0.3L. 0.3l. CD cord-335975-m6lkrehi 1813 1 Oxygenation oxygenation NN cord-335975-m6lkrehi 1813 2 data datum NNS cord-335975-m6lkrehi 1813 3 in in IN cord-335975-m6lkrehi 1813 4 both both DT cord-335975-m6lkrehi 1813 5 parts part NNS cord-335975-m6lkrehi 1813 6 of of IN cord-335975-m6lkrehi 1813 7 the the DT cord-335975-m6lkrehi 1813 8 study study NN cord-335975-m6lkrehi 1813 9 are be VBP cord-335975-m6lkrehi 1813 10 displayed display VBN cord-335975-m6lkrehi 1813 11 in in IN cord-335975-m6lkrehi 1813 12 the the DT cord-335975-m6lkrehi 1813 13 Table table NN cord-335975-m6lkrehi 1813 14 1 1 CD cord-335975-m6lkrehi 1813 15 . . . cord-335975-m6lkrehi 1814 1 Time time NN cord-335975-m6lkrehi 1814 2 in in IN cord-335975-m6lkrehi 1814 3 the the DT cord-335975-m6lkrehi 1814 4 SpO2 SpO2 NNP cord-335975-m6lkrehi 1814 5 target target NN cord-335975-m6lkrehi 1814 6 was be VBD cord-335975-m6lkrehi 1814 7 significantly significantly RB cord-335975-m6lkrehi 1814 8 increased increase VBN cord-335975-m6lkrehi 1814 9 with with IN cord-335975-m6lkrehi 1814 10 FreeO2 freeo2 NN cord-335975-m6lkrehi 1814 11 in in IN cord-335975-m6lkrehi 1814 12 comparison comparison NN cord-335975-m6lkrehi 1814 13 with with IN cord-335975-m6lkrehi 1814 14 manual manual JJ cord-335975-m6lkrehi 1814 15 titration titration NN cord-335975-m6lkrehi 1814 16 and and CC cord-335975-m6lkrehi 1814 17 oxygen oxygen NN cord-335975-m6lkrehi 1814 18 flowrate flowrate NN cord-335975-m6lkrehi 1814 19 was be VBD cord-335975-m6lkrehi 1814 20 reduced reduce VBN cord-335975-m6lkrehi 1814 21 by by IN cord-335975-m6lkrehi 1814 22 half half NN cord-335975-m6lkrehi 1814 23 . . . cord-335975-m6lkrehi 1815 1 In in IN cord-335975-m6lkrehi 1815 2 the the DT cord-335975-m6lkrehi 1815 3 second second JJ cord-335975-m6lkrehi 1815 4 part part NN cord-335975-m6lkrehi 1815 5 of of IN cord-335975-m6lkrehi 1815 6 the the DT cord-335975-m6lkrehi 1815 7 study study NN cord-335975-m6lkrehi 1815 8 , , , cord-335975-m6lkrehi 1815 9 the the DT cord-335975-m6lkrehi 1815 10 % % NN cord-335975-m6lkrehi 1815 11 of of IN cord-335975-m6lkrehi 1815 12 time time NN cord-335975-m6lkrehi 1815 13 in in IN cord-335975-m6lkrehi 1815 14 the the DT cord-335975-m6lkrehi 1815 15 SpO2 SpO2 NNP cord-335975-m6lkrehi 1815 16 target target NN cord-335975-m6lkrehi 1815 17 with with IN cord-335975-m6lkrehi 1815 18 automated automate VBN cord-335975-m6lkrehi 1815 19 oxygen oxygen NN cord-335975-m6lkrehi 1815 20 titration titration NN cord-335975-m6lkrehi 1815 21 was be VBD cord-335975-m6lkrehi 1815 22 above above IN cord-335975-m6lkrehi 1815 23 80 80 CD cord-335975-m6lkrehi 1815 24 % % NN cord-335975-m6lkrehi 1815 25 and and CC cord-335975-m6lkrehi 1815 26 time time NN cord-335975-m6lkrehi 1815 27 with with IN cord-335975-m6lkrehi 1815 28 hypoxemia hypoxemia NN cord-335975-m6lkrehi 1815 29 and and CC cord-335975-m6lkrehi 1815 30 with with IN cord-335975-m6lkrehi 1815 31 hyperoxia hyperoxia NNP cord-335975-m6lkrehi 1815 32 were be VBD cord-335975-m6lkrehi 1815 33 low low JJ cord-335975-m6lkrehi 1815 34 . . . cord-335975-m6lkrehi 1816 1 In in IN cord-335975-m6lkrehi 1816 2 11 11 CD cord-335975-m6lkrehi 1816 3 patients patient NNS cord-335975-m6lkrehi 1816 4 , , , cord-335975-m6lkrehi 1816 5 we -PRON- PRP cord-335975-m6lkrehi 1816 6 compared compare VBD cord-335975-m6lkrehi 1816 7 comfort comfort NN cord-335975-m6lkrehi 1816 8 with with IN cord-335975-m6lkrehi 1816 9 wire wire NN cord-335975-m6lkrehi 1816 10 SpO2 spo2 NN cord-335975-m6lkrehi 1816 11 connection connection NN cord-335975-m6lkrehi 1816 12 to to IN cord-335975-m6lkrehi 1816 13 Bluetooth Bluetooth NNP cord-335975-m6lkrehi 1816 14 wireless wireless NN cord-335975-m6lkrehi 1816 15 SpO2 spo2 NN cord-335975-m6lkrehi 1816 16 connection connection NN cord-335975-m6lkrehi 1816 17 . . . cord-335975-m6lkrehi 1817 1 The the DT cord-335975-m6lkrehi 1817 2 comfort comfort NN cord-335975-m6lkrehi 1817 3 was be VBD cord-335975-m6lkrehi 1817 4 significantly significantly RB cord-335975-m6lkrehi 1817 5 increased increase VBN cord-335975-m6lkrehi 1817 6 with with IN cord-335975-m6lkrehi 1817 7 wireless wireless JJ cord-335975-m6lkrehi 1817 8 connection connection NN cord-335975-m6lkrehi 1817 9 ( ( -LRB- cord-335975-m6lkrehi 1817 10 7.0 7.0 CD cord-335975-m6lkrehi 1817 11 ± ± CD cord-335975-m6lkrehi 1817 12 2.9 2.9 CD cord-335975-m6lkrehi 1817 13 vs. vs. NN cord-335975-m6lkrehi 1817 14 9.7 9.7 CD cord-335975-m6lkrehi 1817 15 ± ± CD cord-335975-m6lkrehi 1817 16 0.6 0.6 CD cord-335975-m6lkrehi 1817 17 , , , cord-335975-m6lkrehi 1817 18 p p NN cord-335975-m6lkrehi 1817 19 < < XX cord-335975-m6lkrehi 1817 20 0.001 0.001 CD cord-335975-m6lkrehi 1817 21 ) ) -RRB- cord-335975-m6lkrehi 1817 22 . . . cord-335975-m6lkrehi 1818 1 Duration duration NN cord-335975-m6lkrehi 1818 2 of of IN cord-335975-m6lkrehi 1818 3 oxygen oxygen NN cord-335975-m6lkrehi 1818 4 administration administration NN cord-335975-m6lkrehi 1818 5 after after IN cord-335975-m6lkrehi 1818 6 inclusion inclusion NN cord-335975-m6lkrehi 1818 7 ( ( -LRB- cord-335975-m6lkrehi 1818 8 2.3 2.3 CD cord-335975-m6lkrehi 1818 9 ± ± CD cord-335975-m6lkrehi 1818 10 4.3 4.3 CD cord-335975-m6lkrehi 1818 11 days day NNS cord-335975-m6lkrehi 1818 12 ) ) -RRB- cord-335975-m6lkrehi 1818 13 and and CC cord-335975-m6lkrehi 1818 14 hospital hospital NN cord-335975-m6lkrehi 1818 15 length length NN cord-335975-m6lkrehi 1818 16 of of IN cord-335975-m6lkrehi 1818 17 stay stay NN cord-335975-m6lkrehi 1818 18 after after IN cord-335975-m6lkrehi 1818 19 inclusion inclusion NN cord-335975-m6lkrehi 1818 20 ( ( -LRB- cord-335975-m6lkrehi 1818 21 5.7 5.7 CD cord-335975-m6lkrehi 1818 22 ± ± NNP cord-335975-m6lkrehi 1818 23 5.3 5.3 CD cord-335975-m6lkrehi 1818 24 days day NNS cord-335975-m6lkrehi 1818 25 ) ) -RRB- cord-335975-m6lkrehi 1818 26 . . . cord-335975-m6lkrehi 1819 1 Conclusion conclusion NN cord-335975-m6lkrehi 1819 2 : : : cord-335975-m6lkrehi 1820 1 Automated automate VBN cord-335975-m6lkrehi 1820 2 oxygen oxygen NN cord-335975-m6lkrehi 1820 3 titration titration NN cord-335975-m6lkrehi 1820 4 maintains maintain VBZ cord-335975-m6lkrehi 1820 5 the the DT cord-335975-m6lkrehi 1820 6 patients patient NNS cord-335975-m6lkrehi 1820 7 within within IN cord-335975-m6lkrehi 1820 8 predetermined predetermined JJ cord-335975-m6lkrehi 1820 9 SpO2 SpO2 NNP cord-335975-m6lkrehi 1820 10 target target NN cord-335975-m6lkrehi 1820 11 more more JJR cord-335975-m6lkrehi 1820 12 than than IN cord-335975-m6lkrehi 1820 13 80 80 CD cord-335975-m6lkrehi 1820 14 % % NN cord-335975-m6lkrehi 1820 15 of of IN cord-335975-m6lkrehi 1820 16 the the DT cord-335975-m6lkrehi 1820 17 time time NN cord-335975-m6lkrehi 1820 18 and and CC cord-335975-m6lkrehi 1820 19 reduces reduce VBZ cord-335975-m6lkrehi 1820 20 oxygen oxygen NN cord-335975-m6lkrehi 1820 21 flowrate flowrate NN cord-335975-m6lkrehi 1820 22 in in IN cord-335975-m6lkrehi 1820 23 comparison comparison NN cord-335975-m6lkrehi 1820 24 with with IN cord-335975-m6lkrehi 1820 25 manual manual JJ cord-335975-m6lkrehi 1820 26 oxygen oxygen NN cord-335975-m6lkrehi 1820 27 titration titration NN cord-335975-m6lkrehi 1820 28 . . . cord-335975-m6lkrehi 1821 1 The the DT cord-335975-m6lkrehi 1821 2 second second JJ cord-335975-m6lkrehi 1821 3 part part NN cord-335975-m6lkrehi 1821 4 of of IN cord-335975-m6lkrehi 1821 5 the the DT cord-335975-m6lkrehi 1821 6 study study NN cord-335975-m6lkrehi 1821 7 demonstrates demonstrate VBZ cord-335975-m6lkrehi 1821 8 the the DT cord-335975-m6lkrehi 1821 9 feasibility feasibility NN cord-335975-m6lkrehi 1821 10 to to TO cord-335975-m6lkrehi 1821 11 use use VB cord-335975-m6lkrehi 1821 12 automated automate VBN cord-335975-m6lkrehi 1821 13 oxygen oxygen NN cord-335975-m6lkrehi 1821 14 titration titration NN cord-335975-m6lkrehi 1821 15 during during IN cord-335975-m6lkrehi 1821 16 several several JJ cord-335975-m6lkrehi 1821 17 days day NNS cord-335975-m6lkrehi 1821 18 with with IN cord-335975-m6lkrehi 1821 19 similar similar JJ cord-335975-m6lkrehi 1821 20 outcomes outcome NNS cord-335975-m6lkrehi 1821 21 as as IN cord-335975-m6lkrehi 1821 22 previously previously RB cord-335975-m6lkrehi 1821 23 reported report VBN cord-335975-m6lkrehi 1821 24 in in IN cord-335975-m6lkrehi 1821 25 similar similar JJ cord-335975-m6lkrehi 1821 26 population population NN cord-335975-m6lkrehi 1821 27 . . . cord-335975-m6lkrehi 1822 1 There there EX cord-335975-m6lkrehi 1822 2 are be VBP cord-335975-m6lkrehi 1822 3 several several JJ cord-335975-m6lkrehi 1822 4 limitations limitation NNS cord-335975-m6lkrehi 1822 5 of of IN cord-335975-m6lkrehi 1822 6 the the DT cord-335975-m6lkrehi 1822 7 study study NN cord-335975-m6lkrehi 1822 8 and and CC cord-335975-m6lkrehi 1822 9 additional additional JJ cord-335975-m6lkrehi 1822 10 evaluations evaluation NNS cord-335975-m6lkrehi 1822 11 of of IN cord-335975-m6lkrehi 1822 12 this this DT cord-335975-m6lkrehi 1822 13 device device NN cord-335975-m6lkrehi 1822 14 are be VBP cord-335975-m6lkrehi 1822 15 required require VBN cord-335975-m6lkrehi 1822 16 . . . cord-335975-m6lkrehi 1823 1 Introduction introduction NN cord-335975-m6lkrehi 1823 2 : : : cord-335975-m6lkrehi 1824 1 Hyperoxemia Hyperoxemia NNP cord-335975-m6lkrehi 1824 2 occurs occur VBZ cord-335975-m6lkrehi 1824 3 up up IN cord-335975-m6lkrehi 1824 4 to to TO cord-335975-m6lkrehi 1824 5 50 50 CD cord-335975-m6lkrehi 1824 6 % % NN cord-335975-m6lkrehi 1824 7 of of IN cord-335975-m6lkrehi 1824 8 mechanical mechanical JJ cord-335975-m6lkrehi 1824 9 ventilation ventilation NN cord-335975-m6lkrehi 1824 10 days day NNS cord-335975-m6lkrehi 1824 11 in in IN cord-335975-m6lkrehi 1824 12 the the DT cord-335975-m6lkrehi 1824 13 ICU ICU NNP cord-335975-m6lkrehi 1824 14 [ [ -LRB- cord-335975-m6lkrehi 1824 15 1 1 CD cord-335975-m6lkrehi 1824 16 ] ] -RRB- cord-335975-m6lkrehi 1824 17 and and CC cord-335975-m6lkrehi 1824 18 is be VBZ cord-335975-m6lkrehi 1824 19 associated associate VBN cord-335975-m6lkrehi 1824 20 with with IN cord-335975-m6lkrehi 1824 21 increased increase VBN cord-335975-m6lkrehi 1824 22 mortality mortality NN cord-335975-m6lkrehi 1824 23 as as IN cord-335975-m6lkrehi 1824 24 compared compare VBN cord-335975-m6lkrehi 1824 25 to to IN cord-335975-m6lkrehi 1824 26 patients patient NNS cord-335975-m6lkrehi 1824 27 ventilated ventilate VBN cord-335975-m6lkrehi 1824 28 in in IN cord-335975-m6lkrehi 1824 29 normoxemia normoxemia NN cord-335975-m6lkrehi 1824 30 [ [ -LRB- cord-335975-m6lkrehi 1824 31 2 2 CD cord-335975-m6lkrehi 1824 32 ] ] -RRB- cord-335975-m6lkrehi 1824 33 . . . cord-335975-m6lkrehi 1825 1 INTELLiVENT INTELLiVENT NNP cord-335975-m6lkrehi 1826 1 -ASV -ASV -LRB- cord-335975-m6lkrehi 1826 2 is be VBZ cord-335975-m6lkrehi 1826 3 a a DT cord-335975-m6lkrehi 1826 4 full full JJ cord-335975-m6lkrehi 1826 5 closed closed JJ cord-335975-m6lkrehi 1826 6 loop loop NN cord-335975-m6lkrehi 1826 7 ventilation ventilation NN cord-335975-m6lkrehi 1826 8 mode mode NN cord-335975-m6lkrehi 1826 9 adjusting adjust VBG cord-335975-m6lkrehi 1826 10 automatically automatically RB cord-335975-m6lkrehi 1826 11 oxygenation oxygenation NN cord-335975-m6lkrehi 1826 12 's 's POS cord-335975-m6lkrehi 1826 13 settings setting NNS cord-335975-m6lkrehi 1826 14 FiO2 FiO2 NNS cord-335975-m6lkrehi 1826 15 and and CC cord-335975-m6lkrehi 1826 16 PEEP peep NN cord-335975-m6lkrehi 1826 17 according accord VBG cord-335975-m6lkrehi 1826 18 to to IN cord-335975-m6lkrehi 1826 19 SpO2 SpO2 NNP cord-335975-m6lkrehi 1826 20 for for IN cord-335975-m6lkrehi 1826 21 passive passive JJ cord-335975-m6lkrehi 1826 22 and and CC cord-335975-m6lkrehi 1826 23 spontaneously spontaneously RB cord-335975-m6lkrehi 1826 24 breathing breathe VBG cord-335975-m6lkrehi 1826 25 mechanically mechanically RB cord-335975-m6lkrehi 1826 26 ventilated ventilate VBD cord-335975-m6lkrehi 1826 27 patients patient NNS cord-335975-m6lkrehi 1826 28 . . . cord-335975-m6lkrehi 1827 1 This this DT cord-335975-m6lkrehi 1827 2 post post FW cord-335975-m6lkrehi 1827 3 hoc hoc FW cord-335975-m6lkrehi 1827 4 analysis analysis NN cord-335975-m6lkrehi 1827 5 of of IN cord-335975-m6lkrehi 1827 6 a a DT cord-335975-m6lkrehi 1827 7 monocentric monocentric JJ cord-335975-m6lkrehi 1827 8 randomized randomized JJ cord-335975-m6lkrehi 1827 9 controlled control VBN cord-335975-m6lkrehi 1827 10 parallel parallel JJ cord-335975-m6lkrehi 1827 11 group group NN cord-335975-m6lkrehi 1827 12 study study NN cord-335975-m6lkrehi 1827 13 compared compare VBN cord-335975-m6lkrehi 1827 14 frequency frequency NN cord-335975-m6lkrehi 1827 15 of of IN cord-335975-m6lkrehi 1827 16 hyperoxemia hyperoxemia NNP cord-335975-m6lkrehi 1827 17 ( ( -LRB- cord-335975-m6lkrehi 1827 18 PaO2 PaO2 NNS cord-335975-m6lkrehi 1827 19 > > XX cord-335975-m6lkrehi 1827 20 120 120 CD cord-335975-m6lkrehi 1827 21 mmHg mmHg NNS cord-335975-m6lkrehi 1827 22 and and CC cord-335975-m6lkrehi 1827 23 or or CC cord-335975-m6lkrehi 1827 24 SpO2 SpO2 NNP cord-335975-m6lkrehi 1827 25 > > XX cord-335975-m6lkrehi 1827 26 96 96 CD cord-335975-m6lkrehi 1827 27 % % NN cord-335975-m6lkrehi 1827 28 ) ) -RRB- cord-335975-m6lkrehi 1827 29 and and CC cord-335975-m6lkrehi 1827 30 hypoxemia hypoxemia NN cord-335975-m6lkrehi 1827 31 ( ( -LRB- cord-335975-m6lkrehi 1827 32 PaO2 PaO2 NNS cord-335975-m6lkrehi 1827 33 < < XX cord-335975-m6lkrehi 1827 34 60 60 CD cord-335975-m6lkrehi 1827 35 mmHg mmHg NNS cord-335975-m6lkrehi 1827 36 and and CC cord-335975-m6lkrehi 1827 37 or or CC cord-335975-m6lkrehi 1827 38 SpO2 SpO2 NNP cord-335975-m6lkrehi 1827 39 < < XX cord-335975-m6lkrehi 1827 40 90 90 CD cord-335975-m6lkrehi 1827 41 % % NN cord-335975-m6lkrehi 1827 42 ) ) -RRB- cord-335975-m6lkrehi 1827 43 and and CC cord-335975-m6lkrehi 1827 44 the the DT cord-335975-m6lkrehi 1827 45 percentage percentage NN cord-335975-m6lkrehi 1827 46 of of IN cord-335975-m6lkrehi 1827 47 ventilation ventilation NN cord-335975-m6lkrehi 1827 48 time time NN cord-335975-m6lkrehi 1827 49 with with IN cord-335975-m6lkrehi 1827 50 SpO2 SpO2 NNP cord-335975-m6lkrehi 1827 51 > > XX cord-335975-m6lkrehi 1827 52 96 96 CD cord-335975-m6lkrehi 1827 53 % % NN cord-335975-m6lkrehi 1827 54 and and CC cord-335975-m6lkrehi 1827 55 the the DT cord-335975-m6lkrehi 1827 56 percentage percentage NN cord-335975-m6lkrehi 1827 57 of of IN cord-335975-m6lkrehi 1827 58 ventilation ventilation NN cord-335975-m6lkrehi 1827 59 time time NN cord-335975-m6lkrehi 1827 60 with with IN cord-335975-m6lkrehi 1827 61 SpO2 SpO2 NNP cord-335975-m6lkrehi 1827 62 < < XX cord-335975-m6lkrehi 1827 63 88 88 CD cord-335975-m6lkrehi 1827 64 % % NN cord-335975-m6lkrehi 1827 65 between between IN cord-335975-m6lkrehi 1827 66 INTELLiVENT INTELLiVENT NNP cord-335975-m6lkrehi 1827 67 - - HYPH cord-335975-m6lkrehi 1827 68 ASV ASV NNP cord-335975-m6lkrehi 1827 69 and and CC cord-335975-m6lkrehi 1827 70 conventional conventional JJ cord-335975-m6lkrehi 1827 71 ventilation ventilation NN cord-335975-m6lkrehi 1827 72 mode mode NN cord-335975-m6lkrehi 1827 73 in in IN cord-335975-m6lkrehi 1827 74 mechanically mechanically RB cord-335975-m6lkrehi 1827 75 ventilated ventilate VBN cord-335975-m6lkrehi 1827 76 ICU ICU NNP cord-335975-m6lkrehi 1827 77 patients patient NNS cord-335975-m6lkrehi 1827 78 . . . cord-335975-m6lkrehi 1828 1 The the DT cord-335975-m6lkrehi 1828 2 randomized randomized JJ cord-335975-m6lkrehi 1828 3 controlled control VBN cord-335975-m6lkrehi 1828 4 trial trial NN cord-335975-m6lkrehi 1828 5 was be VBD cord-335975-m6lkrehi 1828 6 performed perform VBN cord-335975-m6lkrehi 1828 7 in in IN cord-335975-m6lkrehi 1828 8 the the DT cord-335975-m6lkrehi 1828 9 general general JJ cord-335975-m6lkrehi 1828 10 ICU ICU NNP cord-335975-m6lkrehi 1828 11 of of IN cord-335975-m6lkrehi 1828 12 Hôpital Hôpital NNP cord-335975-m6lkrehi 1828 13 Sainte Sainte NNP cord-335975-m6lkrehi 1828 14 Musse Musse NNP cord-335975-m6lkrehi 1828 15 , , , cord-335975-m6lkrehi 1828 16 Toulon Toulon NNP cord-335975-m6lkrehi 1828 17 , , , cord-335975-m6lkrehi 1828 18 France France NNP cord-335975-m6lkrehi 1828 19 . . . cord-335975-m6lkrehi 1829 1 Eligible eligible JJ cord-335975-m6lkrehi 1829 2 participants participant NNS cord-335975-m6lkrehi 1829 3 were be VBD cord-335975-m6lkrehi 1829 4 adult adult NN cord-335975-m6lkrehi 1829 5 aged age VBN cord-335975-m6lkrehi 1829 6 18 18 CD cord-335975-m6lkrehi 1829 7 or or CC cord-335975-m6lkrehi 1829 8 over over RB cord-335975-m6lkrehi 1829 9 , , , cord-335975-m6lkrehi 1829 10 invasively invasively RB cord-335975-m6lkrehi 1829 11 ventilated ventilate VBN cord-335975-m6lkrehi 1829 12 for for IN cord-335975-m6lkrehi 1829 13 less less JJR cord-335975-m6lkrehi 1829 14 than than IN cord-335975-m6lkrehi 1829 15 24 24 CD cord-335975-m6lkrehi 1829 16 h h NN cord-335975-m6lkrehi 1829 17 at at IN cord-335975-m6lkrehi 1829 18 the the DT cord-335975-m6lkrehi 1829 19 time time NN cord-335975-m6lkrehi 1829 20 of of IN cord-335975-m6lkrehi 1829 21 inclusion inclusion NN cord-335975-m6lkrehi 1829 22 with with IN cord-335975-m6lkrehi 1829 23 an an DT cord-335975-m6lkrehi 1829 24 expected expect VBN cord-335975-m6lkrehi 1829 25 duration duration NN cord-335975-m6lkrehi 1829 26 of of IN cord-335975-m6lkrehi 1829 27 mechanical mechanical JJ cord-335975-m6lkrehi 1829 28 ventilation ventilation NN cord-335975-m6lkrehi 1829 29 of of IN cord-335975-m6lkrehi 1829 30 more more JJR cord-335975-m6lkrehi 1829 31 than than IN cord-335975-m6lkrehi 1829 32 48 48 CD cord-335975-m6lkrehi 1829 33 h. h. NNP cord-335975-m6lkrehi 1829 34 Exclusion Exclusion NNP cord-335975-m6lkrehi 1829 35 criteria criterion NNS cord-335975-m6lkrehi 1829 36 were be VBD cord-335975-m6lkrehi 1829 37 broncho broncho JJ cord-335975-m6lkrehi 1829 38 - - HYPH cord-335975-m6lkrehi 1829 39 pleural pleural NN cord-335975-m6lkrehi 1829 40 fistula fistula NN cord-335975-m6lkrehi 1829 41 , , , cord-335975-m6lkrehi 1829 42 ventilation ventilation NN cord-335975-m6lkrehi 1829 43 drive drive NN cord-335975-m6lkrehi 1829 44 disorder disorder NN cord-335975-m6lkrehi 1829 45 and and CC cord-335975-m6lkrehi 1829 46 moribund moribund JJ cord-335975-m6lkrehi 1829 47 patients patient NNS cord-335975-m6lkrehi 1829 48 . . . cord-335975-m6lkrehi 1830 1 Patients patient NNS cord-335975-m6lkrehi 1830 2 were be VBD cord-335975-m6lkrehi 1830 3 allocated allocate VBN cord-335975-m6lkrehi 1830 4 to to IN cord-335975-m6lkrehi 1830 5 INTELLiVENT INTELLiVENT NNP cord-335975-m6lkrehi 1830 6 - - HYPH cord-335975-m6lkrehi 1830 7 ASV ASV NNP cord-335975-m6lkrehi 1830 8 group group NN cord-335975-m6lkrehi 1830 9 or or CC cord-335975-m6lkrehi 1830 10 to to IN cord-335975-m6lkrehi 1830 11 conventional conventional JJ cord-335975-m6lkrehi 1830 12 ventilation ventilation NN cord-335975-m6lkrehi 1830 13 group group NN cord-335975-m6lkrehi 1830 14 ( ( -LRB- cord-335975-m6lkrehi 1830 15 volume volume NN cord-335975-m6lkrehi 1830 16 assist assist VBP cord-335975-m6lkrehi 1830 17 control control NN cord-335975-m6lkrehi 1830 18 and and CC cord-335975-m6lkrehi 1830 19 pressure pressure NN cord-335975-m6lkrehi 1830 20 support support NN cord-335975-m6lkrehi 1830 21 modes mode NNS cord-335975-m6lkrehi 1830 22 ) ) -RRB- cord-335975-m6lkrehi 1830 23 using use VBG cord-335975-m6lkrehi 1830 24 blocked block VBN cord-335975-m6lkrehi 1830 25 randomization randomization NN cord-335975-m6lkrehi 1830 26 . . . cord-335975-m6lkrehi 1831 1 The the DT cord-335975-m6lkrehi 1831 2 post post FW cord-335975-m6lkrehi 1831 3 hoc hoc FW cord-335975-m6lkrehi 1831 4 analysis analysis NN cord-335975-m6lkrehi 1831 5 was be VBD cord-335975-m6lkrehi 1831 6 performed perform VBN cord-335975-m6lkrehi 1831 7 by by IN cord-335975-m6lkrehi 1831 8 the the DT cord-335975-m6lkrehi 1831 9 comparison comparison NN cord-335975-m6lkrehi 1831 10 of of IN cord-335975-m6lkrehi 1831 11 all all DT cord-335975-m6lkrehi 1831 12 arterial arterial JJ cord-335975-m6lkrehi 1831 13 blood blood NN cord-335975-m6lkrehi 1831 14 gases gas NNS cord-335975-m6lkrehi 1831 15 ( ( -LRB- cord-335975-m6lkrehi 1831 16 ABG ABG NNP cord-335975-m6lkrehi 1831 17 ) ) -RRB- cord-335975-m6lkrehi 1831 18 performed perform VBN cord-335975-m6lkrehi 1831 19 during during IN cord-335975-m6lkrehi 1831 20 the the DT cord-335975-m6lkrehi 1831 21 study study NN cord-335975-m6lkrehi 1831 22 period period NN cord-335975-m6lkrehi 1831 23 - - : cord-335975-m6lkrehi 1831 24 the the DT cord-335975-m6lkrehi 1831 25 number number NN cord-335975-m6lkrehi 1831 26 of of IN cord-335975-m6lkrehi 1831 27 ABG ABG NNP cord-335975-m6lkrehi 1831 28 with with IN cord-335975-m6lkrehi 1831 29 hyperoxemia hyperoxemia NN cord-335975-m6lkrehi 1831 30 and and CC cord-335975-m6lkrehi 1831 31 hypoxemia hypoxemia NN cord-335975-m6lkrehi 1831 32 , , , cord-335975-m6lkrehi 1831 33 the the DT cord-335975-m6lkrehi 1831 34 median median JJ cord-335975-m6lkrehi 1831 35 PaO2 PaO2 NNS cord-335975-m6lkrehi 1831 36 and and CC cord-335975-m6lkrehi 1831 37 SpO2 SpO2 NNP cord-335975-m6lkrehi 1831 38 for for IN cord-335975-m6lkrehi 1831 39 these these DT cord-335975-m6lkrehi 1831 40 arterial arterial JJ cord-335975-m6lkrehi 1831 41 blood blood NN cord-335975-m6lkrehi 1831 42 gases gas NNS cord-335975-m6lkrehi 1831 43 and and CC cord-335975-m6lkrehi 1831 44 FiO2 FiO2 NNS cord-335975-m6lkrehi 1831 45 associated associate VBN cord-335975-m6lkrehi 1831 46 were be VBD cord-335975-m6lkrehi 1831 47 compared compare VBN cord-335975-m6lkrehi 1831 48 according accord VBG cord-335975-m6lkrehi 1831 49 to to IN cord-335975-m6lkrehi 1831 50 group group NN cord-335975-m6lkrehi 1831 51 . . . cord-335975-m6lkrehi 1832 1 Results result NNS cord-335975-m6lkrehi 1832 2 : : : cord-335975-m6lkrehi 1832 3 60 60 CD cord-335975-m6lkrehi 1832 4 patients patient NNS cord-335975-m6lkrehi 1832 5 were be VBD cord-335975-m6lkrehi 1832 6 included include VBN cord-335975-m6lkrehi 1832 7 , , , cord-335975-m6lkrehi 1832 8 30 30 CD cord-335975-m6lkrehi 1832 9 patients patient NNS cord-335975-m6lkrehi 1832 10 in in IN cord-335975-m6lkrehi 1832 11 each each DT cord-335975-m6lkrehi 1832 12 group group NN cord-335975-m6lkrehi 1832 13 . . . cord-335975-m6lkrehi 1833 1 The the DT cord-335975-m6lkrehi 1833 2 total total JJ cord-335975-m6lkrehi 1833 3 number number NN cord-335975-m6lkrehi 1833 4 od od NNP cord-335975-m6lkrehi 1833 5 ABG ABG NNP cord-335975-m6lkrehi 1833 6 was be VBD cord-335975-m6lkrehi 1833 7 333 333 CD cord-335975-m6lkrehi 1833 8 ( ( -LRB- cord-335975-m6lkrehi 1833 9 mode mode NN cord-335975-m6lkrehi 1833 10 conventional conventional JJ cord-335975-m6lkrehi 1833 11 ) ) -RRB- cord-335975-m6lkrehi 1833 12 vs vs IN cord-335975-m6lkrehi 1833 13 316 316 CD cord-335975-m6lkrehi 1833 14 ( ( -LRB- cord-335975-m6lkrehi 1833 15 mode mode NN cord-335975-m6lkrehi 1833 16 INTEL INTEL NNP cord-335975-m6lkrehi 1833 17 - - HYPH cord-335975-m6lkrehi 1833 18 LiVENT LiVENT NNP cord-335975-m6lkrehi 1833 19 - - HYPH cord-335975-m6lkrehi 1833 20 ASV ASV NNP cord-335975-m6lkrehi 1833 21 ) ) -RRB- cord-335975-m6lkrehi 1834 1 ( ( -LRB- cord-335975-m6lkrehi 1834 2 p p NN cord-335975-m6lkrehi 1834 3 = = SYM cord-335975-m6lkrehi 1834 4 ns ns NNP cord-335975-m6lkrehi 1834 5 ) ) -RRB- cord-335975-m6lkrehi 1834 6 . . . cord-335975-m6lkrehi 1835 1 The the DT cord-335975-m6lkrehi 1835 2 number number NN cord-335975-m6lkrehi 1835 3 of of IN cord-335975-m6lkrehi 1835 4 ABG ABG NNP cord-335975-m6lkrehi 1835 5 with with IN cord-335975-m6lkrehi 1835 6 PaO2 PaO2 NNS cord-335975-m6lkrehi 1835 7 > > XX cord-335975-m6lkrehi 1835 8 120 120 CD cord-335975-m6lkrehi 1835 9 mmHg mmHg NNPS cord-335975-m6lkrehi 1835 10 was be VBD cord-335975-m6lkrehi 1835 11 respectively respectively RB cord-335975-m6lkrehi 1835 12 54 54 CD cord-335975-m6lkrehi 1835 13 versus versus IN cord-335975-m6lkrehi 1835 14 33 33 CD cord-335975-m6lkrehi 1835 15 ( ( -LRB- cord-335975-m6lkrehi 1835 16 p p NN cord-335975-m6lkrehi 1835 17 = = SYM cord-335975-m6lkrehi 1835 18 0.032 0.032 CD cord-335975-m6lkrehi 1835 19 ) ) -RRB- cord-335975-m6lkrehi 1835 20 with with IN cord-335975-m6lkrehi 1835 21 SaO2 SaO2 NNS cord-335975-m6lkrehi 1836 1 > > XX cord-335975-m6lkrehi 1836 2 96 96 CD cord-335975-m6lkrehi 1836 3 % % NN cord-335975-m6lkrehi 1836 4 was be VBD cord-335975-m6lkrehi 1836 5 203 203 CD cord-335975-m6lkrehi 1836 6 vs vs IN cord-335975-m6lkrehi 1836 7 153 153 CD cord-335975-m6lkrehi 1836 8 ( ( -LRB- cord-335975-m6lkrehi 1836 9 p p NN cord-335975-m6lkrehi 1836 10 = = SYM cord-335975-m6lkrehi 1836 11 0.001 0.001 CD cord-335975-m6lkrehi 1836 12 ) ) -RRB- cord-335975-m6lkrehi 1836 13 with with IN cord-335975-m6lkrehi 1836 14 PaO2 PaO2 NNS cord-335975-m6lkrehi 1837 1 < < NNP cord-335975-m6lkrehi 1837 2 60 60 CD cord-335975-m6lkrehi 1837 3 mmHg mmHg NNS cord-335975-m6lkrehi 1837 4 was be VBD cord-335975-m6lkrehi 1837 5 57 57 CD cord-335975-m6lkrehi 1837 6 vs vs IN cord-335975-m6lkrehi 1837 7 56 56 CD cord-335975-m6lkrehi 1837 8 ( ( -LRB- cord-335975-m6lkrehi 1837 9 p p NN cord-335975-m6lkrehi 1837 10 = = SYM cord-335975-m6lkrehi 1837 11 0.121 0.121 CD cord-335975-m6lkrehi 1837 12 ) ) -RRB- cord-335975-m6lkrehi 1838 1 + + CC cord-335975-m6lkrehi 1838 2 with with IN cord-335975-m6lkrehi 1838 3 Sao2 Sao2 NNP cord-335975-m6lkrehi 1838 4 < < XX cord-335975-m6lkrehi 1838 5 90 90 CD cord-335975-m6lkrehi 1838 6 % % NN cord-335975-m6lkrehi 1838 7 was be VBD cord-335975-m6lkrehi 1838 8 88 88 CD cord-335975-m6lkrehi 1838 9 vs vs IN cord-335975-m6lkrehi 1838 10 86 86 CD cord-335975-m6lkrehi 1839 1 ( ( -LRB- cord-335975-m6lkrehi 1839 2 p p NN cord-335975-m6lkrehi 1839 3 = = SYM cord-335975-m6lkrehi 1839 4 0.951 0.951 CD cord-335975-m6lkrehi 1839 5 ) ) -RRB- cord-335975-m6lkrehi 1839 6 . . . cord-335975-m6lkrehi 1840 1 The the DT cord-335975-m6lkrehi 1840 2 percentage percentage NN cord-335975-m6lkrehi 1840 3 of of IN cord-335975-m6lkrehi 1840 4 time time NN cord-335975-m6lkrehi 1840 5 of of IN cord-335975-m6lkrehi 1840 6 ventilation ventilation NN cord-335975-m6lkrehi 1840 7 spent spend VBN cord-335975-m6lkrehi 1840 8 with with IN cord-335975-m6lkrehi 1840 9 Spo2 Spo2 NNP cord-335975-m6lkrehi 1840 10 > > NNP cord-335975-m6lkrehi 1840 11 96 96 CD cord-335975-m6lkrehi 1840 12 % % NN cord-335975-m6lkrehi 1840 13 was be VBD cord-335975-m6lkrehi 1840 14 32 32 CD cord-335975-m6lkrehi 1840 15 % % NN cord-335975-m6lkrehi 1840 16 vs vs IN cord-335975-m6lkrehi 1840 17 29 29 CD cord-335975-m6lkrehi 1840 18 ( ( -LRB- cord-335975-m6lkrehi 1840 19 p p NN cord-335975-m6lkrehi 1840 20 = = SYM cord-335975-m6lkrehi 1840 21 0.438 0.438 CD cord-335975-m6lkrehi 1840 22 ) ) -RRB- cord-335975-m6lkrehi 1840 23 , , , cord-335975-m6lkrehi 1840 24 and and CC cord-335975-m6lkrehi 1840 25 with with IN cord-335975-m6lkrehi 1840 26 Sao2 Sao2 NNP cord-335975-m6lkrehi 1840 27 < < XX cord-335975-m6lkrehi 1840 28 88 88 CD cord-335975-m6lkrehi 1840 29 % % NN cord-335975-m6lkrehi 1840 30 was be VBD cord-335975-m6lkrehi 1840 31 0.6 0.6 CD cord-335975-m6lkrehi 1840 32 vs vs IN cord-335975-m6lkrehi 1840 33 0.5 0.5 CD cord-335975-m6lkrehi 1840 34 ( ( -LRB- cord-335975-m6lkrehi 1840 35 p p NN cord-335975-m6lkrehi 1840 36 = = SYM cord-335975-m6lkrehi 1840 37 0.615 0.615 CD cord-335975-m6lkrehi 1840 38 ) ) -RRB- cord-335975-m6lkrehi 1840 39 . . . cord-335975-m6lkrehi 1841 1 The the DT cord-335975-m6lkrehi 1841 2 continuous continuous JJ cord-335975-m6lkrehi 1841 3 control control NN cord-335975-m6lkrehi 1841 4 of of IN cord-335975-m6lkrehi 1841 5 oxygenation oxygenation NN cord-335975-m6lkrehi 1841 6 settings setting NNS cord-335975-m6lkrehi 1841 7 provided provide VBN cord-335975-m6lkrehi 1841 8 by by IN cord-335975-m6lkrehi 1841 9 INTELLiVENT INTELLiVENT NNP cord-335975-m6lkrehi 1841 10 - - HYPH cord-335975-m6lkrehi 1841 11 ASV ASV NNP cord-335975-m6lkrehi 1841 12 decreases decrease VBZ cord-335975-m6lkrehi 1841 13 significantly significantly RB cord-335975-m6lkrehi 1841 14 the the DT cord-335975-m6lkrehi 1841 15 number number NN cord-335975-m6lkrehi 1841 16 of of IN cord-335975-m6lkrehi 1841 17 blood blood NN cord-335975-m6lkrehi 1841 18 gas gas NN cord-335975-m6lkrehi 1841 19 with with IN cord-335975-m6lkrehi 1841 20 hyperoxemia hyperoxemia NN cord-335975-m6lkrehi 1841 21 as as IN cord-335975-m6lkrehi 1841 22 compared compare VBN cord-335975-m6lkrehi 1841 23 to to IN cord-335975-m6lkrehi 1841 24 manual manual JJ cord-335975-m6lkrehi 1841 25 oxygenation oxygenation NN cord-335975-m6lkrehi 1841 26 setting set VBG cord-335975-m6lkrehi 1841 27 without without IN cord-335975-m6lkrehi 1841 28 increasing increase VBG cord-335975-m6lkrehi 1841 29 the the DT cord-335975-m6lkrehi 1841 30 risk risk NN cord-335975-m6lkrehi 1841 31 of of IN cord-335975-m6lkrehi 1841 32 hypoxemia hypoxemia NN cord-335975-m6lkrehi 1841 33 . . . cord-335975-m6lkrehi 1842 1 Introduction introduction NN cord-335975-m6lkrehi 1842 2 : : : cord-335975-m6lkrehi 1843 1 In in IN cord-335975-m6lkrehi 1843 2 invasively invasively RB cord-335975-m6lkrehi 1843 3 mechanically mechanically RB cord-335975-m6lkrehi 1843 4 ventilated ventilate VBN cord-335975-m6lkrehi 1843 5 patient patient NN cord-335975-m6lkrehi 1843 6 , , , cord-335975-m6lkrehi 1843 7 dyspnea dyspnea NN cord-335975-m6lkrehi 1843 8 is be VBZ cord-335975-m6lkrehi 1843 9 frequent frequent JJ cord-335975-m6lkrehi 1843 10 and and CC cord-335975-m6lkrehi 1843 11 severe severe JJ cord-335975-m6lkrehi 1843 12 . . . cord-335975-m6lkrehi 1844 1 Relying rely VBG cord-335975-m6lkrehi 1844 2 on on IN cord-335975-m6lkrehi 1844 3 self self NN cord-335975-m6lkrehi 1844 4 - - HYPH cord-335975-m6lkrehi 1844 5 report report NN cord-335975-m6lkrehi 1844 6 , , , cord-335975-m6lkrehi 1844 7 its -PRON- PRP$ cord-335975-m6lkrehi 1844 8 measurement measurement NN cord-335975-m6lkrehi 1844 9 remains remain VBZ cord-335975-m6lkrehi 1844 10 challenging challenge VBG cord-335975-m6lkrehi 1844 11 in in IN cord-335975-m6lkrehi 1844 12 patients patient NNS cord-335975-m6lkrehi 1844 13 unable unable JJ cord-335975-m6lkrehi 1844 14 to to TO cord-335975-m6lkrehi 1844 15 communicate communicate VB cord-335975-m6lkrehi 1844 16 . . . cord-335975-m6lkrehi 1845 1 A a DT cord-335975-m6lkrehi 1845 2 5-item 5-item CD cord-335975-m6lkrehi 1845 3 observation observation NN cord-335975-m6lkrehi 1845 4 scale scale NN cord-335975-m6lkrehi 1845 5 , , , cord-335975-m6lkrehi 1845 6 namely namely RB cord-335975-m6lkrehi 1845 7 the the DT cord-335975-m6lkrehi 1845 8 intensive intensive JJ cord-335975-m6lkrehi 1845 9 care care NN cord-335975-m6lkrehi 1845 10 - - HYPH cord-335975-m6lkrehi 1845 11 respiratory respiratory JJ cord-335975-m6lkrehi 1845 12 distress distress NN cord-335975-m6lkrehi 1845 13 observation observation NN cord-335975-m6lkrehi 1845 14 scale scale NN cord-335975-m6lkrehi 1845 15 ( ( -LRB- cord-335975-m6lkrehi 1845 16 IC IC NNP cord-335975-m6lkrehi 1845 17 - - HYPH cord-335975-m6lkrehi 1845 18 RDOS RDOS NNP cord-335975-m6lkrehi 1845 19 ) ) -RRB- cord-335975-m6lkrehi 1845 20 , , , cord-335975-m6lkrehi 1845 21 has have VBZ cord-335975-m6lkrehi 1845 22 been be VBN cord-335975-m6lkrehi 1845 23 proposed propose VBN cord-335975-m6lkrehi 1845 24 as as IN cord-335975-m6lkrehi 1845 25 a a DT cord-335975-m6lkrehi 1845 26 surrogate surrogate NN cord-335975-m6lkrehi 1845 27 of of IN cord-335975-m6lkrehi 1845 28 dyspnea dyspnea NN cord-335975-m6lkrehi 1845 29 - - HYPH cord-335975-m6lkrehi 1845 30 visual visual JJ cord-335975-m6lkrehi 1845 31 analogic analogic JJ cord-335975-m6lkrehi 1845 32 scale scale NN cord-335975-m6lkrehi 1845 33 ( ( -LRB- cord-335975-m6lkrehi 1845 34 D D NNP cord-335975-m6lkrehi 1845 35 - - HYPH cord-335975-m6lkrehi 1845 36 VAS VAS NNP cord-335975-m6lkrehi 1845 37 ) ) -RRB- cord-335975-m6lkrehi 1845 38 self self NN cord-335975-m6lkrehi 1845 39 - - HYPH cord-335975-m6lkrehi 1845 40 report report VBP cord-335975-m6lkrehi 1845 41 in in IN cord-335975-m6lkrehi 1845 42 intensive intensive JJ cord-335975-m6lkrehi 1845 43 care care NN cord-335975-m6lkrehi 1845 44 unit unit NN cord-335975-m6lkrehi 1845 45 ( ( -LRB- cord-335975-m6lkrehi 1845 46 ICU ICU NNP cord-335975-m6lkrehi 1845 47 ) ) -RRB- cord-335975-m6lkrehi 1845 48 patients patient NNS cord-335975-m6lkrehi 1845 49 [ [ -LRB- cord-335975-m6lkrehi 1845 50 1 1 CD cord-335975-m6lkrehi 1845 51 ] ] -RRB- cord-335975-m6lkrehi 1845 52 . . . cord-335975-m6lkrehi 1846 1 However however RB cord-335975-m6lkrehi 1846 2 this this DT cord-335975-m6lkrehi 1846 3 scale scale NN cord-335975-m6lkrehi 1846 4 has have VBZ cord-335975-m6lkrehi 1846 5 been be VBN cord-335975-m6lkrehi 1846 6 validated validate VBN cord-335975-m6lkrehi 1846 7 among among IN cord-335975-m6lkrehi 1846 8 non non JJ cord-335975-m6lkrehi 1846 9 - - JJ cord-335975-m6lkrehi 1846 10 intubated intubate VBN cord-335975-m6lkrehi 1846 11 patients patient NNS cord-335975-m6lkrehi 1846 12 and and CC cord-335975-m6lkrehi 1846 13 included include VBD cord-335975-m6lkrehi 1846 14 one one CD cord-335975-m6lkrehi 1846 15 item item NN cord-335975-m6lkrehi 1846 16 " " `` cord-335975-m6lkrehi 1846 17 supplemental supplemental JJ cord-335975-m6lkrehi 1846 18 oxygen oxygen NN cord-335975-m6lkrehi 1846 19 " " '' cord-335975-m6lkrehi 1846 20 not not RB cord-335975-m6lkrehi 1846 21 thoroughly thoroughly RB cord-335975-m6lkrehi 1846 22 adapted adapt VBN cord-335975-m6lkrehi 1846 23 for for IN cord-335975-m6lkrehi 1846 24 intubated intubate VBN cord-335975-m6lkrehi 1846 25 population population NN cord-335975-m6lkrehi 1846 26 . . . cord-335975-m6lkrehi 1847 1 We -PRON- PRP cord-335975-m6lkrehi 1847 2 sought seek VBD cord-335975-m6lkrehi 1847 3 to to TO cord-335975-m6lkrehi 1847 4 develop develop VB cord-335975-m6lkrehi 1847 5 a a DT cord-335975-m6lkrehi 1847 6 dyspnea dyspnea NN cord-335975-m6lkrehi 1847 7 observation observation NN cord-335975-m6lkrehi 1847 8 scale scale NN cord-335975-m6lkrehi 1847 9 more more RBR cord-335975-m6lkrehi 1847 10 suitable suitable JJ cord-335975-m6lkrehi 1847 11 for for IN cord-335975-m6lkrehi 1847 12 intubated intubated JJ cord-335975-m6lkrehi 1847 13 patients patient NNS cord-335975-m6lkrehi 1847 14 and and CC cord-335975-m6lkrehi 1847 15 to to TO cord-335975-m6lkrehi 1847 16 evaluate evaluate VB cord-335975-m6lkrehi 1847 17 its -PRON- PRP$ cord-335975-m6lkrehi 1847 18 performance performance NN cord-335975-m6lkrehi 1847 19 to to TO cord-335975-m6lkrehi 1847 20 detect detect VB cord-335975-m6lkrehi 1847 21 dyspnea dyspnea NN cord-335975-m6lkrehi 1847 22 . . . cord-335975-m6lkrehi 1848 1 Patients patient NNS cord-335975-m6lkrehi 1848 2 and and CC cord-335975-m6lkrehi 1848 3 methods method NNS cord-335975-m6lkrehi 1848 4 : : : cord-335975-m6lkrehi 1848 5 Ancillary ancillary JJ cord-335975-m6lkrehi 1848 6 analysis analysis NN cord-335975-m6lkrehi 1848 7 of of IN cord-335975-m6lkrehi 1848 8 data datum NNS cord-335975-m6lkrehi 1848 9 prospectively prospectively RB cord-335975-m6lkrehi 1848 10 collected collect VBN cord-335975-m6lkrehi 1848 11 from from IN cord-335975-m6lkrehi 1848 12 220 220 CD cord-335975-m6lkrehi 1848 13 ICU ICU NNP cord-335975-m6lkrehi 1848 14 communicative communicative JJ cord-335975-m6lkrehi 1848 15 patients patient NNS cord-335975-m6lkrehi 1848 16 enrolled enrol VBN cord-335975-m6lkrehi 1848 17 for for IN cord-335975-m6lkrehi 1848 18 the the DT cord-335975-m6lkrehi 1848 19 validation validation NN cord-335975-m6lkrehi 1848 20 of of IN cord-335975-m6lkrehi 1848 21 the the DT cord-335975-m6lkrehi 1848 22 IC IC NNP cord-335975-m6lkrehi 1848 23 - - HYPH cord-335975-m6lkrehi 1848 24 RDOS RDOS NNP cord-335975-m6lkrehi 1848 25 . . . cord-335975-m6lkrehi 1849 1 Factorial factorial JJ cord-335975-m6lkrehi 1849 2 principal principal JJ cord-335975-m6lkrehi 1849 3 component component NN cord-335975-m6lkrehi 1849 4 analysis analysis NN cord-335975-m6lkrehi 1849 5 was be VBD cord-335975-m6lkrehi 1849 6 first first RB cord-335975-m6lkrehi 1849 7 performed perform VBN cord-335975-m6lkrehi 1849 8 to to TO cord-335975-m6lkrehi 1849 9 select select VB cord-335975-m6lkrehi 1849 10 variables variable NNS cord-335975-m6lkrehi 1849 11 that that WDT cord-335975-m6lkrehi 1849 12 mostly mostly RB cord-335975-m6lkrehi 1849 13 contributed contribute VBD cord-335975-m6lkrehi 1849 14 to to IN cord-335975-m6lkrehi 1849 15 the the DT cord-335975-m6lkrehi 1849 16 principal principal JJ cord-335975-m6lkrehi 1849 17 axes axis NNS cord-335975-m6lkrehi 1849 18 , , , cord-335975-m6lkrehi 1849 19 among among IN cord-335975-m6lkrehi 1849 20 a a DT cord-335975-m6lkrehi 1849 21 set set NN cord-335975-m6lkrehi 1849 22 of of IN cord-335975-m6lkrehi 1849 23 21 21 CD cord-335975-m6lkrehi 1849 24 observable observable JJ cord-335975-m6lkrehi 1849 25 variables variable NNS cord-335975-m6lkrehi 1849 26 with with IN cord-335975-m6lkrehi 1849 27 possible possible JJ cord-335975-m6lkrehi 1849 28 clinical clinical JJ cord-335975-m6lkrehi 1849 29 relevance relevance NN cord-335975-m6lkrehi 1849 30 . . . cord-335975-m6lkrehi 1850 1 To to TO cord-335975-m6lkrehi 1850 2 identify identify VB cord-335975-m6lkrehi 1850 3 the the DT cord-335975-m6lkrehi 1850 4 best good JJS cord-335975-m6lkrehi 1850 5 correlation correlation NN cord-335975-m6lkrehi 1850 6 between between IN cord-335975-m6lkrehi 1850 7 these these DT cord-335975-m6lkrehi 1850 8 variables variable NNS cord-335975-m6lkrehi 1850 9 and and CC cord-335975-m6lkrehi 1850 10 D D NNP cord-335975-m6lkrehi 1850 11 - - HYPH cord-335975-m6lkrehi 1850 12 VAS VAS NNP cord-335975-m6lkrehi 1850 13 , , , cord-335975-m6lkrehi 1850 14 were be VBD cord-335975-m6lkrehi 1850 15 performed perform VBN cord-335975-m6lkrehi 1850 16 an an DT cord-335975-m6lkrehi 1850 17 iterative iterative JJ cord-335975-m6lkrehi 1850 18 partial partial JJ cord-335975-m6lkrehi 1850 19 least least JJS cord-335975-m6lkrehi 1850 20 square square JJ cord-335975-m6lkrehi 1850 21 regression regression NN cord-335975-m6lkrehi 1850 22 process process NN cord-335975-m6lkrehi 1850 23 ( ( -LRB- cord-335975-m6lkrehi 1850 24 PLS PLS NNP cord-335975-m6lkrehi 1850 25 ) ) -RRB- cord-335975-m6lkrehi 1850 26 . . . cord-335975-m6lkrehi 1851 1 Iterative iterative JJ cord-335975-m6lkrehi 1851 2 PLS PLS NNP cord-335975-m6lkrehi 1851 3 procedure procedure NN cord-335975-m6lkrehi 1851 4 identified identify VBD cord-335975-m6lkrehi 1851 5 five five CD cord-335975-m6lkrehi 1851 6 variables variable NNS cord-335975-m6lkrehi 1851 7 , , , cord-335975-m6lkrehi 1851 8 of of IN cord-335975-m6lkrehi 1851 9 which which WDT cord-335975-m6lkrehi 1851 10 the the DT cord-335975-m6lkrehi 1851 11 combination combination NN cord-335975-m6lkrehi 1851 12 and and CC cord-335975-m6lkrehi 1851 13 weighting weighting NN cord-335975-m6lkrehi 1851 14 allowed allow VBN cord-335975-m6lkrehi 1851 15 optimal optimal JJ cord-335975-m6lkrehi 1851 16 correlation correlation NN cord-335975-m6lkrehi 1851 17 with with IN cord-335975-m6lkrehi 1851 18 D D NNP cord-335975-m6lkrehi 1851 19 - - HYPH cord-335975-m6lkrehi 1851 20 VAS vas NN cord-335975-m6lkrehi 1852 1 ( ( -LRB- cord-335975-m6lkrehi 1852 2 r r NN cord-335975-m6lkrehi 1852 3 = = SYM cord-335975-m6lkrehi 1852 4 0.61 0.61 CD cord-335975-m6lkrehi 1852 5 ; ; : cord-335975-m6lkrehi 1852 6 95 95 CD cord-335975-m6lkrehi 1852 7 % % NN cord-335975-m6lkrehi 1852 8 CI CI NNP cord-335975-m6lkrehi 1852 9 0.50 0.50 CD cord-335975-m6lkrehi 1852 10 to to IN cord-335975-m6lkrehi 1852 11 0.72 0.72 CD cord-335975-m6lkrehi 1852 12 ; ; : cord-335975-m6lkrehi 1852 13 p p NN cord-335975-m6lkrehi 1852 14 value value NN cord-335975-m6lkrehi 1852 15 < < XX cord-335975-m6lkrehi 1852 16 0.0001 0.0001 CD cord-335975-m6lkrehi 1852 17 ) ) -RRB- cord-335975-m6lkrehi 1852 18 , , , cord-335975-m6lkrehi 1852 19 which which WDT cord-335975-m6lkrehi 1852 20 constitute constitute VBP cord-335975-m6lkrehi 1852 21 the the DT cord-335975-m6lkrehi 1852 22 IC IC NNP cord-335975-m6lkrehi 1852 23 - - HYPH cord-335975-m6lkrehi 1852 24 RDOS RDOS NNP cord-335975-m6lkrehi 1852 25 [ [ -LRB- cord-335975-m6lkrehi 1852 26 1 1 CD cord-335975-m6lkrehi 1852 27 ] ] -RRB- cord-335975-m6lkrehi 1852 28 . . . cord-335975-m6lkrehi 1853 1 In in IN cord-335975-m6lkrehi 1853 2 a a DT cord-335975-m6lkrehi 1853 3 first first JJ cord-335975-m6lkrehi 1853 4 step step NN cord-335975-m6lkrehi 1853 5 , , , cord-335975-m6lkrehi 1853 6 we -PRON- PRP cord-335975-m6lkrehi 1853 7 removed remove VBD cord-335975-m6lkrehi 1853 8 " " `` cord-335975-m6lkrehi 1853 9 supplemental supplemental JJ cord-335975-m6lkrehi 1853 10 oxygen oxygen NN cord-335975-m6lkrehi 1853 11 " " '' cord-335975-m6lkrehi 1853 12 , , , cord-335975-m6lkrehi 1853 13 not not RB cord-335975-m6lkrehi 1853 14 relevant relevant JJ cord-335975-m6lkrehi 1853 15 in in IN cord-335975-m6lkrehi 1853 16 intubated intubated JJ cord-335975-m6lkrehi 1853 17 patients patient NNS cord-335975-m6lkrehi 1853 18 . . . cord-335975-m6lkrehi 1854 1 We -PRON- PRP cord-335975-m6lkrehi 1854 2 obtained obtain VBD cord-335975-m6lkrehi 1854 3 a a DT cord-335975-m6lkrehi 1854 4 4-items 4-items CD cord-335975-m6lkrehi 1854 5 IC IC NNP cord-335975-m6lkrehi 1854 6 - - HYPH cord-335975-m6lkrehi 1854 7 RDOS RDOS NNP cord-335975-m6lkrehi 1855 1 ( ( -LRB- cord-335975-m6lkrehi 1855 2 r r NN cord-335975-m6lkrehi 1855 3 = = SYM cord-335975-m6lkrehi 1855 4 0 0 CD cord-335975-m6lkrehi 1855 5 . . . cord-335975-m6lkrehi 1856 1 Introduction introduction NN cord-335975-m6lkrehi 1856 2 : : : cord-335975-m6lkrehi 1857 1 Lung lung NN cord-335975-m6lkrehi 1857 2 ultrasound ultrasound NN cord-335975-m6lkrehi 1857 3 ( ( -LRB- cord-335975-m6lkrehi 1857 4 LUS LUS NNP cord-335975-m6lkrehi 1857 5 ) ) -RRB- cord-335975-m6lkrehi 1857 6 has have VBZ cord-335975-m6lkrehi 1857 7 emerged emerge VBN cord-335975-m6lkrehi 1857 8 in in IN cord-335975-m6lkrehi 1857 9 different different JJ cord-335975-m6lkrehi 1857 10 clinical clinical JJ cord-335975-m6lkrehi 1857 11 settings setting NNS cord-335975-m6lkrehi 1857 12 , , , cord-335975-m6lkrehi 1857 13 such such JJ cord-335975-m6lkrehi 1857 14 as as IN cord-335975-m6lkrehi 1857 15 in in IN cord-335975-m6lkrehi 1857 16 intensive intensive JJ cord-335975-m6lkrehi 1857 17 care care NN cord-335975-m6lkrehi 1857 18 medicine medicine NN cord-335975-m6lkrehi 1857 19 ( ( -LRB- cord-335975-m6lkrehi 1857 20 ICM ICM NNP cord-335975-m6lkrehi 1857 21 ) ) -RRB- cord-335975-m6lkrehi 1857 22 . . . cord-335975-m6lkrehi 1858 1 Early early JJ cord-335975-m6lkrehi 1858 2 diagnosis diagnosis NN cord-335975-m6lkrehi 1858 3 of of IN cord-335975-m6lkrehi 1858 4 ventilator ventilator NN cord-335975-m6lkrehi 1858 5 - - HYPH cord-335975-m6lkrehi 1858 6 associated associate VBN cord-335975-m6lkrehi 1858 7 pneumonia pneumonia NN cord-335975-m6lkrehi 1858 8 ( ( -LRB- cord-335975-m6lkrehi 1858 9 VAP VAP NNP cord-335975-m6lkrehi 1858 10 ) ) -RRB- cord-335975-m6lkrehi 1858 11 remains remain VBZ cord-335975-m6lkrehi 1858 12 a a DT cord-335975-m6lkrehi 1858 13 challenge challenge NN cord-335975-m6lkrehi 1858 14 to to IN cord-335975-m6lkrehi 1858 15 the the DT cord-335975-m6lkrehi 1858 16 intensivist intensivist NN cord-335975-m6lkrehi 1858 17 . . . cord-335975-m6lkrehi 1859 1 However however RB cord-335975-m6lkrehi 1859 2 , , , cord-335975-m6lkrehi 1859 3 scientific scientific JJ cord-335975-m6lkrehi 1859 4 evidence evidence NN cord-335975-m6lkrehi 1859 5 is be VBZ cord-335975-m6lkrehi 1859 6 little little RB cord-335975-m6lkrehi 1859 7 available available JJ cord-335975-m6lkrehi 1859 8 on on IN cord-335975-m6lkrehi 1859 9 whether whether IN cord-335975-m6lkrehi 1859 10 LUS LUS NNP cord-335975-m6lkrehi 1859 11 reliably reliably RB cord-335975-m6lkrehi 1859 12 improves improve VBZ cord-335975-m6lkrehi 1859 13 the the DT cord-335975-m6lkrehi 1859 14 diagnosis diagnosis NN cord-335975-m6lkrehi 1859 15 of of IN cord-335975-m6lkrehi 1859 16 VAP VAP NNP cord-335975-m6lkrehi 1859 17 . . . cord-335975-m6lkrehi 1860 1 The the DT cord-335975-m6lkrehi 1860 2 aim aim NN cord-335975-m6lkrehi 1860 3 of of IN cord-335975-m6lkrehi 1860 4 this this DT cord-335975-m6lkrehi 1860 5 prospective prospective JJ cord-335975-m6lkrehi 1860 6 study study NN cord-335975-m6lkrehi 1860 7 was be VBD cord-335975-m6lkrehi 1860 8 to to TO cord-335975-m6lkrehi 1860 9 assess assess VB cord-335975-m6lkrehi 1860 10 whether whether IN cord-335975-m6lkrehi 1860 11 LUS LUS NNP cord-335975-m6lkrehi 1860 12 could could MD cord-335975-m6lkrehi 1860 13 be be VB cord-335975-m6lkrehi 1860 14 an an DT cord-335975-m6lkrehi 1860 15 alternative alternative NN cord-335975-m6lkrehi 1860 16 to to IN cord-335975-m6lkrehi 1860 17 pulmonary pulmonary JJ cord-335975-m6lkrehi 1860 18 computerized computerized NN cord-335975-m6lkrehi 1860 19 Tomography Tomography NNP cord-335975-m6lkrehi 1860 20 ( ( -LRB- cord-335975-m6lkrehi 1860 21 CT CT NNP cord-335975-m6lkrehi 1860 22 ) ) -RRB- cord-335975-m6lkrehi 1860 23 for for IN cord-335975-m6lkrehi 1860 24 assessing assess VBG cord-335975-m6lkrehi 1860 25 diagnosis diagnosis NN cord-335975-m6lkrehi 1860 26 of of IN cord-335975-m6lkrehi 1860 27 VAP VAP NNP cord-335975-m6lkrehi 1860 28 in in IN cord-335975-m6lkrehi 1860 29 ICM ICM NNP cord-335975-m6lkrehi 1860 30 . . . cord-335975-m6lkrehi 1861 1 Patients patient NNS cord-335975-m6lkrehi 1861 2 and and CC cord-335975-m6lkrehi 1861 3 methods method NNS cord-335975-m6lkrehi 1861 4 : : : cord-335975-m6lkrehi 1861 5 Twenty twenty CD cord-335975-m6lkrehi 1861 6 - - HYPH cord-335975-m6lkrehi 1861 7 one one CD cord-335975-m6lkrehi 1861 8 patients patient NNS cord-335975-m6lkrehi 1861 9 ventilated ventilate VBN cord-335975-m6lkrehi 1861 10 for for IN cord-335975-m6lkrehi 1861 11 duration duration NN cord-335975-m6lkrehi 1861 12 more more JJR cord-335975-m6lkrehi 1861 13 than than IN cord-335975-m6lkrehi 1861 14 5 5 CD cord-335975-m6lkrehi 1861 15 days day NNS cord-335975-m6lkrehi 1861 16 suspected suspect VBN cord-335975-m6lkrehi 1861 17 of of IN cord-335975-m6lkrehi 1861 18 VAP VAP NNP cord-335975-m6lkrehi 1861 19 were be VBD cord-335975-m6lkrehi 1861 20 included include VBN cord-335975-m6lkrehi 1861 21 . . . cord-335975-m6lkrehi 1862 1 LUS LUS NNP cord-335975-m6lkrehi 1862 2 was be VBD cord-335975-m6lkrehi 1862 3 performed perform VBN cord-335975-m6lkrehi 1862 4 by by IN cord-335975-m6lkrehi 1862 5 a a DT cord-335975-m6lkrehi 1862 6 well well RB cord-335975-m6lkrehi 1862 7 - - HYPH cord-335975-m6lkrehi 1862 8 trained train VBN cord-335975-m6lkrehi 1862 9 operator operator NN cord-335975-m6lkrehi 1862 10 who who WP cord-335975-m6lkrehi 1862 11 was be VBD cord-335975-m6lkrehi 1862 12 blinded blind VBN cord-335975-m6lkrehi 1862 13 of of IN cord-335975-m6lkrehi 1862 14 the the DT cord-335975-m6lkrehi 1862 15 VAP VAP NNP cord-335975-m6lkrehi 1862 16 diagnosis diagnosis NN cord-335975-m6lkrehi 1862 17 . . . cord-335975-m6lkrehi 1863 1 The the DT cord-335975-m6lkrehi 1863 2 diagnostic diagnostic JJ cord-335975-m6lkrehi 1863 3 gold gold NN cord-335975-m6lkrehi 1863 4 standard standard NN cord-335975-m6lkrehi 1863 5 of of IN cord-335975-m6lkrehi 1863 6 VAP VAP NNP cord-335975-m6lkrehi 1863 7 was be VBD cord-335975-m6lkrehi 1863 8 on on IN cord-335975-m6lkrehi 1863 9 the the DT cord-335975-m6lkrehi 1863 10 basis basis NN cord-335975-m6lkrehi 1863 11 of of IN cord-335975-m6lkrehi 1863 12 pulmonary pulmonary JJ cord-335975-m6lkrehi 1863 13 CT CT NNP cord-335975-m6lkrehi 1863 14 and and CC cord-335975-m6lkrehi 1863 15 positive positive JJ cord-335975-m6lkrehi 1863 16 culture culture NN cord-335975-m6lkrehi 1863 17 pulmonary pulmonary JJ cord-335975-m6lkrehi 1863 18 . . . cord-335975-m6lkrehi 1864 1 All all DT cord-335975-m6lkrehi 1864 2 clinical clinical JJ cord-335975-m6lkrehi 1864 3 criteria criterion NNS cord-335975-m6lkrehi 1864 4 for for IN cord-335975-m6lkrehi 1864 5 the the DT cord-335975-m6lkrehi 1864 6 diagnosis diagnosis NN cord-335975-m6lkrehi 1864 7 were be VBD cord-335975-m6lkrehi 1864 8 collected collect VBN cord-335975-m6lkrehi 1864 9 the the DT cord-335975-m6lkrehi 1864 10 same same JJ cord-335975-m6lkrehi 1864 11 day day NN cord-335975-m6lkrehi 1864 12 of of IN cord-335975-m6lkrehi 1864 13 LUS LUS NNP cord-335975-m6lkrehi 1864 14 and and CC cord-335975-m6lkrehi 1864 15 pulmonary pulmonary JJ cord-335975-m6lkrehi 1864 16 CT CT NNP cord-335975-m6lkrehi 1864 17 . . . cord-335975-m6lkrehi 1865 1 The the DT cord-335975-m6lkrehi 1865 2 ultrasound ultrasound NN cord-335975-m6lkrehi 1865 3 exam exam NN cord-335975-m6lkrehi 1865 4 included include VBD cord-335975-m6lkrehi 1865 5 anterior anterior JJ cord-335975-m6lkrehi 1865 6 , , , cord-335975-m6lkrehi 1865 7 lateral lateral JJ cord-335975-m6lkrehi 1865 8 and and CC cord-335975-m6lkrehi 1865 9 posterior posterior JJ cord-335975-m6lkrehi 1865 10 views view NNS cord-335975-m6lkrehi 1865 11 from from IN cord-335975-m6lkrehi 1865 12 both both DT cord-335975-m6lkrehi 1865 13 sides side NNS cord-335975-m6lkrehi 1865 14 of of IN cord-335975-m6lkrehi 1865 15 the the DT cord-335975-m6lkrehi 1865 16 chest chest NN cord-335975-m6lkrehi 1865 17 with with IN cord-335975-m6lkrehi 1865 18 superior superior JJ cord-335975-m6lkrehi 1865 19 and and CC cord-335975-m6lkrehi 1865 20 inferior inferior JJ cord-335975-m6lkrehi 1865 21 views view NNS cord-335975-m6lkrehi 1865 22 . . . cord-335975-m6lkrehi 1866 1 We -PRON- PRP cord-335975-m6lkrehi 1866 2 classed class VBD cord-335975-m6lkrehi 1866 3 patient patient NN cord-335975-m6lkrehi 1866 4 in in IN cord-335975-m6lkrehi 1866 5 4 4 CD cord-335975-m6lkrehi 1866 6 groups group NNS cord-335975-m6lkrehi 1866 7 according accord VBG cord-335975-m6lkrehi 1866 8 diagnosis diagnosis NN cord-335975-m6lkrehi 1866 9 of of IN cord-335975-m6lkrehi 1866 10 VAP VAP NNP cord-335975-m6lkrehi 1866 11 with with IN cord-335975-m6lkrehi 1866 12 pulmonary pulmonary JJ cord-335975-m6lkrehi 1866 13 CT CT NNP cord-335975-m6lkrehi 1866 14 ( ( -LRB- cord-335975-m6lkrehi 1866 15 VAP VAP NNP cord-335975-m6lkrehi 1866 16 + + CC cord-335975-m6lkrehi 1866 17 or or CC cord-335975-m6lkrehi 1866 18 VAP- VAP- NNP cord-335975-m6lkrehi 1866 19 ) ) -RRB- cord-335975-m6lkrehi 1866 20 and and CC cord-335975-m6lkrehi 1866 21 LUS LUS NNP cord-335975-m6lkrehi 1866 22 ( ( -LRB- cord-335975-m6lkrehi 1866 23 LUS LUS NNP cord-335975-m6lkrehi 1866 24 + + CC cord-335975-m6lkrehi 1866 25 or or CC cord-335975-m6lkrehi 1866 26 LUS- LUS- NNP cord-335975-m6lkrehi 1866 27 ) ) -RRB- cord-335975-m6lkrehi 1866 28 . . . cord-335975-m6lkrehi 1867 1 LUS LUS NNP cord-335975-m6lkrehi 1867 2 characteristics characteristic NNS cord-335975-m6lkrehi 1867 3 of of IN cord-335975-m6lkrehi 1867 4 VAP VAP NNP cord-335975-m6lkrehi 1867 5 diagnosis diagnosis NN cord-335975-m6lkrehi 1867 6 included include VBD cord-335975-m6lkrehi 1867 7 9 9 CD cord-335975-m6lkrehi 1867 8 profils profil NNS cord-335975-m6lkrehi 1867 9 - - HYPH cord-335975-m6lkrehi 1867 10 asymetric asymetric JJ cord-335975-m6lkrehi 1867 11 line line NN cord-335975-m6lkrehi 1867 12 B b NN cord-335975-m6lkrehi 1867 13 ( ( -LRB- cord-335975-m6lkrehi 1867 14 profil profil NNP cord-335975-m6lkrehi 1867 15 A A NNP cord-335975-m6lkrehi 1867 16 B B NNP cord-335975-m6lkrehi 1867 17 ) ) -RRB- cord-335975-m6lkrehi 1867 18 , , , cord-335975-m6lkrehi 1867 19 without without IN cord-335975-m6lkrehi 1867 20 sliding slide VBG cord-335975-m6lkrehi 1867 21 ( ( -LRB- cord-335975-m6lkrehi 1867 22 profil profil NNP cord-335975-m6lkrehi 1867 23 B B NNP cord-335975-m6lkrehi 1867 24 ' ' '' cord-335975-m6lkrehi 1867 25 ) ) -RRB- cord-335975-m6lkrehi 1867 26 , , , cord-335975-m6lkrehi 1867 27 sub sub NNP cord-335975-m6lkrehi 1867 28 pleural pleural JJ cord-335975-m6lkrehi 1867 29 consolidation consolidation NN cord-335975-m6lkrehi 1867 30 ( ( -LRB- cord-335975-m6lkrehi 1867 31 profil profil NNP cord-335975-m6lkrehi 1867 32 C C NNP cord-335975-m6lkrehi 1867 33 ) ) -RRB- cord-335975-m6lkrehi 1867 34 , , , cord-335975-m6lkrehi 1867 35 consolidation consolidation NN cord-335975-m6lkrehi 1867 36 with with IN cord-335975-m6lkrehi 1867 37 punctiforme punctiforme NNP cord-335975-m6lkrehi 1867 38 bronchogram bronchogram NNP cord-335975-m6lkrehi 1867 39 ( ( -LRB- cord-335975-m6lkrehi 1867 40 PB PB NNP cord-335975-m6lkrehi 1867 41 ) ) -RRB- cord-335975-m6lkrehi 1867 42 , , , cord-335975-m6lkrehi 1867 43 linear linear NNP cord-335975-m6lkrehi 1867 44 air air NN cord-335975-m6lkrehi 1867 45 bronchograms bronchograms NNP cord-335975-m6lkrehi 1867 46 ( ( -LRB- cord-335975-m6lkrehi 1867 47 LB LB NNP cord-335975-m6lkrehi 1867 48 ) ) -RRB- cord-335975-m6lkrehi 1867 49 or or CC cord-335975-m6lkrehi 1867 50 dynamic dynamic JJ cord-335975-m6lkrehi 1867 51 bronchograms bronchogram NNS cord-335975-m6lkrehi 1867 52 ( ( -LRB- cord-335975-m6lkrehi 1867 53 LBD LBD NNP cord-335975-m6lkrehi 1867 54 ) ) -RRB- cord-335975-m6lkrehi 1867 55 , , , cord-335975-m6lkrehi 1867 56 posteror posteror NNP cord-335975-m6lkrehi 1867 57 lateral lateral JJ cord-335975-m6lkrehi 1867 58 alveolar alveolar JJ cord-335975-m6lkrehi 1867 59 pleural pleural JJ cord-335975-m6lkrehi 1867 60 suffusion suffusion NN cord-335975-m6lkrehi 1867 61 ( ( -LRB- cord-335975-m6lkrehi 1867 62 PLAPS PLAPS NNP cord-335975-m6lkrehi 1867 63 ) ) -RRB- cord-335975-m6lkrehi 1867 64 , , , cord-335975-m6lkrehi 1867 65 pleural pleural JJ cord-335975-m6lkrehi 1867 66 effusion effusion NN cord-335975-m6lkrehi 1867 67 pathological pathological JJ cord-335975-m6lkrehi 1867 68 ( ( -LRB- cord-335975-m6lkrehi 1867 69 PEP pep NN cord-335975-m6lkrehi 1867 70 ) ) -RRB- cord-335975-m6lkrehi 1867 71 , , , cord-335975-m6lkrehi 1867 72 shred shred JJ cord-335975-m6lkrehi 1867 73 sign sign NN cord-335975-m6lkrehi 1867 74 ( ( -LRB- cord-335975-m6lkrehi 1867 75 SS SS NNP cord-335975-m6lkrehi 1867 76 and and CC cord-335975-m6lkrehi 1867 77 complications complication NNS cord-335975-m6lkrehi 1867 78 according accord VBG cord-335975-m6lkrehi 1867 79 to to IN cord-335975-m6lkrehi 1867 80 insertion insertion NN cord-335975-m6lkrehi 1867 81 site site NN cord-335975-m6lkrehi 1867 82 . . . cord-335975-m6lkrehi 1868 1 The the DT cord-335975-m6lkrehi 1868 2 advantage advantage NN cord-335975-m6lkrehi 1868 3 of of IN cord-335975-m6lkrehi 1868 4 this this DT cord-335975-m6lkrehi 1868 5 method method NN cord-335975-m6lkrehi 1868 6 is be VBZ cord-335975-m6lkrehi 1868 7 that that IN cord-335975-m6lkrehi 1868 8 it -PRON- PRP cord-335975-m6lkrehi 1868 9 gives give VBZ cord-335975-m6lkrehi 1868 10 a a DT cord-335975-m6lkrehi 1868 11 pragmatic pragmatic JJ cord-335975-m6lkrehi 1868 12 view view NN cord-335975-m6lkrehi 1868 13 of of IN cord-335975-m6lkrehi 1868 14 the the DT cord-335975-m6lkrehi 1868 15 real real JJ cord-335975-m6lkrehi 1868 16 clinical clinical JJ cord-335975-m6lkrehi 1868 17 situation situation NN cord-335975-m6lkrehi 1868 18 . . . cord-335975-m6lkrehi 1869 1 Patients patient NNS cord-335975-m6lkrehi 1869 2 and and CC cord-335975-m6lkrehi 1869 3 methods method NNS cord-335975-m6lkrehi 1869 4 : : : cord-335975-m6lkrehi 1869 5 Ancillary ancillary JJ cord-335975-m6lkrehi 1869 6 study study NN cord-335975-m6lkrehi 1869 7 of of IN cord-335975-m6lkrehi 1869 8 the the DT cord-335975-m6lkrehi 1869 9 AKIKI AKIKI NNP cord-335975-m6lkrehi 1869 10 trial trial NN cord-335975-m6lkrehi 1869 11 , , , cord-335975-m6lkrehi 1869 12 an an DT cord-335975-m6lkrehi 1869 13 open open JJ cord-335975-m6lkrehi 1869 14 pragmatic pragmatic JJ cord-335975-m6lkrehi 1869 15 randomized randomize VBN cord-335975-m6lkrehi 1869 16 controlled control VBN cord-335975-m6lkrehi 1869 17 trial trial NN cord-335975-m6lkrehi 1869 18 published publish VBN cord-335975-m6lkrehi 1869 19 in in IN cord-335975-m6lkrehi 1869 20 2016 2016 CD cord-335975-m6lkrehi 1869 21 , , , cord-335975-m6lkrehi 1869 22 in in IN cord-335975-m6lkrehi 1869 23 which which WDT cord-335975-m6lkrehi 1869 24 patients patient NNS cord-335975-m6lkrehi 1869 25 with with IN cord-335975-m6lkrehi 1869 26 severe severe JJ cord-335975-m6lkrehi 1869 27 acute acute JJ cord-335975-m6lkrehi 1869 28 kidney kidney NN cord-335975-m6lkrehi 1869 29 injury injury NN cord-335975-m6lkrehi 1869 30 were be VBD cord-335975-m6lkrehi 1869 31 randomly randomly RB cord-335975-m6lkrehi 1869 32 assigned assign VBN cord-335975-m6lkrehi 1869 33 to to IN cord-335975-m6lkrehi 1869 34 either either CC cord-335975-m6lkrehi 1869 35 an an DT cord-335975-m6lkrehi 1869 36 early early JJ cord-335975-m6lkrehi 1869 37 or or CC cord-335975-m6lkrehi 1869 38 a a DT cord-335975-m6lkrehi 1869 39 delayed delay VBN cord-335975-m6lkrehi 1869 40 RRT rrt NN cord-335975-m6lkrehi 1869 41 initiation initiation NN cord-335975-m6lkrehi 1869 42 strategy strategy NN cord-335975-m6lkrehi 1869 43 . . . cord-335975-m6lkrehi 1870 1 The the DT cord-335975-m6lkrehi 1870 2 present present JJ cord-335975-m6lkrehi 1870 3 study study NN cord-335975-m6lkrehi 1870 4 involved involve VBD cord-335975-m6lkrehi 1870 5 all all DT cord-335975-m6lkrehi 1870 6 patients patient NNS cord-335975-m6lkrehi 1870 7 who who WP cord-335975-m6lkrehi 1870 8 underwent undergo VBD cord-335975-m6lkrehi 1870 9 at at RB cord-335975-m6lkrehi 1870 10 least least JJS cord-335975-m6lkrehi 1870 11 one one CD cord-335975-m6lkrehi 1870 12 RRT rrt NN cord-335975-m6lkrehi 1870 13 session session NN cord-335975-m6lkrehi 1870 14 . . . cord-335975-m6lkrehi 1871 1 Number number NN cord-335975-m6lkrehi 1871 2 of of IN cord-335975-m6lkrehi 1871 3 RRT RRT NNP cord-335975-m6lkrehi 1871 4 catheters catheter NNS cord-335975-m6lkrehi 1871 5 , , , cord-335975-m6lkrehi 1871 6 insertion insertion NN cord-335975-m6lkrehi 1871 7 sites site NNS cord-335975-m6lkrehi 1871 8 , , , cord-335975-m6lkrehi 1871 9 factors factor NNS cord-335975-m6lkrehi 1871 10 potentially potentially RB cord-335975-m6lkrehi 1871 11 associated associate VBN cord-335975-m6lkrehi 1871 12 with with IN cord-335975-m6lkrehi 1871 13 the the DT cord-335975-m6lkrehi 1871 14 choice choice NN cord-335975-m6lkrehi 1871 15 of of IN cord-335975-m6lkrehi 1871 16 insertion insertion NN cord-335975-m6lkrehi 1871 17 site site NN cord-335975-m6lkrehi 1871 18 , , , cord-335975-m6lkrehi 1871 19 duration duration NN cord-335975-m6lkrehi 1871 20 of of IN cord-335975-m6lkrehi 1871 21 catheter catheter NN cord-335975-m6lkrehi 1871 22 use use NN cord-335975-m6lkrehi 1871 23 , , , cord-335975-m6lkrehi 1871 24 reason reason NN cord-335975-m6lkrehi 1871 25 for for IN cord-335975-m6lkrehi 1871 26 catheter catheter NN cord-335975-m6lkrehi 1871 27 replacement replacement NN cord-335975-m6lkrehi 1871 28 , , , cord-335975-m6lkrehi 1871 29 and and CC cord-335975-m6lkrehi 1871 30 complications complication NNS cord-335975-m6lkrehi 1871 31 were be VBD cord-335975-m6lkrehi 1871 32 prospectively prospectively RB cord-335975-m6lkrehi 1871 33 collected collect VBN cord-335975-m6lkrehi 1871 34 . . . cord-335975-m6lkrehi 1872 1 Results result NNS cord-335975-m6lkrehi 1872 2 : : : cord-335975-m6lkrehi 1873 1 Among among IN cord-335975-m6lkrehi 1873 2 the the DT cord-335975-m6lkrehi 1873 3 619 619 CD cord-335975-m6lkrehi 1873 4 patients patient NNS cord-335975-m6lkrehi 1873 5 included include VBN cord-335975-m6lkrehi 1873 6 in in IN cord-335975-m6lkrehi 1873 7 AKIKI AKIKI NNP cord-335975-m6lkrehi 1873 8 , , , cord-335975-m6lkrehi 1873 9 462 462 CD cord-335975-m6lkrehi 1873 10 received receive VBD cord-335975-m6lkrehi 1873 11 RRT RRT NNP cord-335975-m6lkrehi 1873 12 at at IN cord-335975-m6lkrehi 1873 13 least least JJS cord-335975-m6lkrehi 1873 14 once once RB cord-335975-m6lkrehi 1873 15 and and CC cord-335975-m6lkrehi 1873 16 459 459 CD cord-335975-m6lkrehi 1873 17 patients patient NNS cord-335975-m6lkrehi 1873 18 were be VBD cord-335975-m6lkrehi 1873 19 finally finally RB cord-335975-m6lkrehi 1873 20 included include VBN cord-335975-m6lkrehi 1873 21 in in IN cord-335975-m6lkrehi 1873 22 the the DT cord-335975-m6lkrehi 1873 23 analysis analysis NN cord-335975-m6lkrehi 1873 24 ( ( -LRB- cord-335975-m6lkrehi 1873 25 3 3 CD cord-335975-m6lkrehi 1873 26 missing miss VBG cord-335975-m6lkrehi 1873 27 data datum NNS cord-335975-m6lkrehi 1873 28 ) ) -RRB- cord-335975-m6lkrehi 1873 29 , , , cord-335975-m6lkrehi 1873 30 leading lead VBG cord-335975-m6lkrehi 1873 31 to to IN cord-335975-m6lkrehi 1873 32 a a DT cord-335975-m6lkrehi 1873 33 total total NN cord-335975-m6lkrehi 1873 34 of of IN cord-335975-m6lkrehi 1873 35 598 598 CD cord-335975-m6lkrehi 1873 36 RRT RRT NNP cord-335975-m6lkrehi 1873 37 catheters catheter NNS cord-335975-m6lkrehi 1873 38 . . . cord-335975-m6lkrehi 1874 1 Femoral femoral JJ cord-335975-m6lkrehi 1874 2 site site NN cord-335975-m6lkrehi 1874 3 was be VBD cord-335975-m6lkrehi 1874 4 chosen choose VBN cord-335975-m6lkrehi 1874 5 preferentially preferentially RB cord-335975-m6lkrehi 1874 6 ( ( -LRB- cord-335975-m6lkrehi 1874 7 n n NN cord-335975-m6lkrehi 1874 8 = = SYM cord-335975-m6lkrehi 1874 9 319 319 CD cord-335975-m6lkrehi 1874 10 , , , cord-335975-m6lkrehi 1874 11 53 53 CD cord-335975-m6lkrehi 1874 12 % % NN cord-335975-m6lkrehi 1874 13 ) ) -RRB- cord-335975-m6lkrehi 1874 14 , , , cord-335975-m6lkrehi 1874 15 followed follow VBN cord-335975-m6lkrehi 1874 16 by by IN cord-335975-m6lkrehi 1874 17 jugular jugular NN cord-335975-m6lkrehi 1874 18 site site NN cord-335975-m6lkrehi 1874 19 ( ( -LRB- cord-335975-m6lkrehi 1874 20 n n NN cord-335975-m6lkrehi 1874 21 = = SYM cord-335975-m6lkrehi 1874 22 256 256 CD cord-335975-m6lkrehi 1874 23 , , , cord-335975-m6lkrehi 1874 24 43 43 CD cord-335975-m6lkrehi 1874 25 % % NN cord-335975-m6lkrehi 1874 26 ) ) -RRB- cord-335975-m6lkrehi 1874 27 and and CC cord-335975-m6lkrehi 1874 28 subclavian subclavian JJ cord-335975-m6lkrehi 1874 29 site site NN cord-335975-m6lkrehi 1875 1 ( ( -LRB- cord-335975-m6lkrehi 1875 2 n n NN cord-335975-m6lkrehi 1875 3 = = SYM cord-335975-m6lkrehi 1875 4 23 23 CD cord-335975-m6lkrehi 1875 5 , , , cord-335975-m6lkrehi 1875 6 4 4 CD cord-335975-m6lkrehi 1875 7 % % NN cord-335975-m6lkrehi 1875 8 ) ) -RRB- cord-335975-m6lkrehi 1875 9 . . . cord-335975-m6lkrehi 1876 1 Investigating investigate VBG cord-335975-m6lkrehi 1876 2 center center NN cord-335975-m6lkrehi 1876 3 was be VBD cord-335975-m6lkrehi 1876 4 the the DT cord-335975-m6lkrehi 1876 5 sole sole JJ cord-335975-m6lkrehi 1876 6 factor factor NN cord-335975-m6lkrehi 1876 7 significantly significantly RB cord-335975-m6lkrehi 1876 8 associated associate VBD cord-335975-m6lkrehi 1876 9 with with IN cord-335975-m6lkrehi 1876 10 the the DT cord-335975-m6lkrehi 1876 11 choice choice NN cord-335975-m6lkrehi 1876 12 of of IN cord-335975-m6lkrehi 1876 13 insertion insertion NN cord-335975-m6lkrehi 1876 14 site site NN cord-335975-m6lkrehi 1876 15 in in IN cord-335975-m6lkrehi 1876 16 multivariate multivariate JJ cord-335975-m6lkrehi 1876 17 analysis analysis NN cord-335975-m6lkrehi 1877 1 ( ( -LRB- cord-335975-m6lkrehi 1877 2 p p NN cord-335975-m6lkrehi 1877 3 = = SYM cord-335975-m6lkrehi 1877 4 0.01 0.01 CD cord-335975-m6lkrehi 1877 5 ) ) -RRB- cord-335975-m6lkrehi 1877 6 . . . cord-335975-m6lkrehi 1878 1 Higher high JJR cord-335975-m6lkrehi 1878 2 weight weight NN cord-335975-m6lkrehi 1878 3 did do VBD cord-335975-m6lkrehi 1878 4 not not RB cord-335975-m6lkrehi 1878 5 affect affect VB cord-335975-m6lkrehi 1878 6 choice choice NN cord-335975-m6lkrehi 1878 7 of of IN cord-335975-m6lkrehi 1878 8 insertion insertion NN cord-335975-m6lkrehi 1878 9 site site NN cord-335975-m6lkrehi 1878 10 . . . cord-335975-m6lkrehi 1879 1 Mean mean JJ cord-335975-m6lkrehi 1879 2 duration duration NN cord-335975-m6lkrehi 1879 3 of of IN cord-335975-m6lkrehi 1879 4 catheter catheter NN cord-335975-m6lkrehi 1879 5 use use NN cord-335975-m6lkrehi 1879 6 was be VBD cord-335975-m6lkrehi 1879 7 6.6 6.6 CD cord-335975-m6lkrehi 1879 8 ( ( -LRB- cord-335975-m6lkrehi 1879 9 + + CD cord-335975-m6lkrehi 1879 10 -5.0 -5.0 CD cord-335975-m6lkrehi 1879 11 ) ) -RRB- cord-335975-m6lkrehi 1879 12 days day NNS cord-335975-m6lkrehi 1879 13 without without IN cord-335975-m6lkrehi 1879 14 difference difference NN cord-335975-m6lkrehi 1879 15 according accord VBG cord-335975-m6lkrehi 1879 16 to to IN cord-335975-m6lkrehi 1879 17 site site NN cord-335975-m6lkrehi 1879 18 . . . cord-335975-m6lkrehi 1880 1 Catheter catheter NN cord-335975-m6lkrehi 1880 2 dysfunction dysfunction NN cord-335975-m6lkrehi 1880 3 was be VBD cord-335975-m6lkrehi 1880 4 the the DT cord-335975-m6lkrehi 1880 5 main main JJ cord-335975-m6lkrehi 1880 6 reason reason NN cord-335975-m6lkrehi 1880 7 for for IN cord-335975-m6lkrehi 1880 8 replacement replacement NN cord-335975-m6lkrehi 1880 9 ( ( -LRB- cord-335975-m6lkrehi 1880 10 n n NN cord-335975-m6lkrehi 1880 11 = = SYM cord-335975-m6lkrehi 1880 12 61 61 CD cord-335975-m6lkrehi 1880 13 , , , cord-335975-m6lkrehi 1880 14 49 49 CD cord-335975-m6lkrehi 1880 15 % % NN cord-335975-m6lkrehi 1880 16 ) ) -RRB- cord-335975-m6lkrehi 1880 17 . . . cord-335975-m6lkrehi 1881 1 Suspicion suspicion NN cord-335975-m6lkrehi 1881 2 of of IN cord-335975-m6lkrehi 1881 3 infection infection NN cord-335975-m6lkrehi 1881 4 led lead VBD cord-335975-m6lkrehi 1881 5 to to IN cord-335975-m6lkrehi 1881 6 replacement replacement NN cord-335975-m6lkrehi 1881 7 of of IN cord-335975-m6lkrehi 1881 8 many many JJ cord-335975-m6lkrehi 1881 9 catheters catheter NNS cord-335975-m6lkrehi 1881 10 ( ( -LRB- cord-335975-m6lkrehi 1881 11 n n NN cord-335975-m6lkrehi 1881 12 = = SYM cord-335975-m6lkrehi 1881 13 40 40 CD cord-335975-m6lkrehi 1881 14 , , , cord-335975-m6lkrehi 1881 15 32 32 CD cord-335975-m6lkrehi 1881 16 % % NN cord-335975-m6lkrehi 1881 17 ) ) -RRB- cord-335975-m6lkrehi 1881 18 but but CC cord-335975-m6lkrehi 1881 19 was be VBD cord-335975-m6lkrehi 1881 20 actually actually RB cord-335975-m6lkrehi 1881 21 seldom seldom RB cord-335975-m6lkrehi 1881 22 proven prove VBN cord-335975-m6lkrehi 1882 1 ( ( -LRB- cord-335975-m6lkrehi 1882 2 n n NN cord-335975-m6lkrehi 1882 3 = = SYM cord-335975-m6lkrehi 1882 4 4 4 CD cord-335975-m6lkrehi 1882 5 , , , cord-335975-m6lkrehi 1882 6 3 3 CD cord-335975-m6lkrehi 1882 7 % % NN cord-335975-m6lkrehi 1882 8 Introduction introduction NN cord-335975-m6lkrehi 1882 9 : : : cord-335975-m6lkrehi 1882 10 Long long RB cord-335975-m6lkrehi 1882 11 standing stand VBG cord-335975-m6lkrehi 1882 12 dialysis dialysis NN cord-335975-m6lkrehi 1882 13 ( ( -LRB- cord-335975-m6lkrehi 1882 14 SLED SLED NNP cord-335975-m6lkrehi 1882 15 or or CC cord-335975-m6lkrehi 1882 16 CRRT CRRT NNP cord-335975-m6lkrehi 1882 17 ) ) -RRB- cord-335975-m6lkrehi 1882 18 allows allow VBZ cord-335975-m6lkrehi 1882 19 a a DT cord-335975-m6lkrehi 1882 20 better well JJR cord-335975-m6lkrehi 1882 21 hemodynamic hemodynamic JJ cord-335975-m6lkrehi 1882 22 tolerance tolerance NN cord-335975-m6lkrehi 1882 23 as as RB cord-335975-m6lkrehi 1882 24 well well RB cord-335975-m6lkrehi 1882 25 as as IN cord-335975-m6lkrehi 1882 26 a a DT cord-335975-m6lkrehi 1882 27 greater great JJR cord-335975-m6lkrehi 1882 28 performance performance NN cord-335975-m6lkrehi 1882 29 to to TO cord-335975-m6lkrehi 1882 30 achieve achieve VB cord-335975-m6lkrehi 1882 31 a a DT cord-335975-m6lkrehi 1882 32 negative negative JJ cord-335975-m6lkrehi 1882 33 fluid fluid JJ cord-335975-m6lkrehi 1882 34 balance balance NN cord-335975-m6lkrehi 1882 35 in in IN cord-335975-m6lkrehi 1882 36 intensive intensive JJ cord-335975-m6lkrehi 1882 37 care care NN cord-335975-m6lkrehi 1882 38 unit unit NN cord-335975-m6lkrehi 1882 39 . . . cord-335975-m6lkrehi 1883 1 Dialysis dialysis NN cord-335975-m6lkrehi 1883 2 alter alter VBP cord-335975-m6lkrehi 1883 3 hemodynamics hemodynamic NNS cord-335975-m6lkrehi 1883 4 mainly mainly RB cord-335975-m6lkrehi 1883 5 by by IN cord-335975-m6lkrehi 1883 6 short short JJ cord-335975-m6lkrehi 1883 7 term term NN cord-335975-m6lkrehi 1883 8 variation variation NN cord-335975-m6lkrehi 1883 9 of of IN cord-335975-m6lkrehi 1883 10 blood blood NN cord-335975-m6lkrehi 1883 11 volume volume NN cord-335975-m6lkrehi 1883 12 . . . cord-335975-m6lkrehi 1884 1 In in IN cord-335975-m6lkrehi 1884 2 this this DT cord-335975-m6lkrehi 1884 3 study study NN cord-335975-m6lkrehi 1884 4 we -PRON- PRP cord-335975-m6lkrehi 1884 5 took take VBD cord-335975-m6lkrehi 1884 6 advantage advantage NN cord-335975-m6lkrehi 1884 7 of of IN cord-335975-m6lkrehi 1884 8 a a DT cord-335975-m6lkrehi 1884 9 continuous continuous JJ cord-335975-m6lkrehi 1884 10 monitoring monitoring NN cord-335975-m6lkrehi 1884 11 of of IN cord-335975-m6lkrehi 1884 12 blood blood NN cord-335975-m6lkrehi 1884 13 volume volume NN cord-335975-m6lkrehi 1884 14 during during IN cord-335975-m6lkrehi 1884 15 dialysis dialysis NN cord-335975-m6lkrehi 1884 16 session session NN cord-335975-m6lkrehi 1884 17 to to TO cord-335975-m6lkrehi 1884 18 decipher decipher VB cord-335975-m6lkrehi 1884 19 the the DT cord-335975-m6lkrehi 1884 20 relationship relationship NN cord-335975-m6lkrehi 1884 21 between between IN cord-335975-m6lkrehi 1884 22 the the DT cord-335975-m6lkrehi 1884 23 variation variation NN cord-335975-m6lkrehi 1884 24 of of IN cord-335975-m6lkrehi 1884 25 relative relative JJ cord-335975-m6lkrehi 1884 26 blood blood NN cord-335975-m6lkrehi 1884 27 volume volume NN cord-335975-m6lkrehi 1884 28 ( ( -LRB- cord-335975-m6lkrehi 1884 29 RBV RBV NNP cord-335975-m6lkrehi 1884 30 ) ) -RRB- cord-335975-m6lkrehi 1884 31 with with IN cord-335975-m6lkrehi 1884 32 mean mean JJ cord-335975-m6lkrehi 1884 33 arterial arterial JJ cord-335975-m6lkrehi 1884 34 pressure pressure NN cord-335975-m6lkrehi 1884 35 ( ( -LRB- cord-335975-m6lkrehi 1884 36 MAP MAP NNP cord-335975-m6lkrehi 1884 37 ) ) -RRB- cord-335975-m6lkrehi 1884 38 . . . cord-335975-m6lkrehi 1885 1 This this DT cord-335975-m6lkrehi 1885 2 study study NN cord-335975-m6lkrehi 1885 3 is be VBZ cord-335975-m6lkrehi 1885 4 observational observational JJ cord-335975-m6lkrehi 1885 5 prospective prospective NN cord-335975-m6lkrehi 1885 6 , , , cord-335975-m6lkrehi 1885 7 including include VBG cord-335975-m6lkrehi 1885 8 all all DT cord-335975-m6lkrehi 1885 9 prolonged prolong VBN cord-335975-m6lkrehi 1885 10 ( ( -LRB- cord-335975-m6lkrehi 1885 11 > > NFP cord-335975-m6lkrehi 1885 12 8 8 CD cord-335975-m6lkrehi 1885 13 h h NN cord-335975-m6lkrehi 1885 14 ) ) -RRB- cord-335975-m6lkrehi 1885 15 dialysis dialysis NN cord-335975-m6lkrehi 1885 16 sessions session NNS cord-335975-m6lkrehi 1885 17 in in IN cord-335975-m6lkrehi 1885 18 Saint Saint NNP cord-335975-m6lkrehi 1885 19 Etienne Etienne NNP cord-335975-m6lkrehi 1885 20 nephrology nephrology NN cord-335975-m6lkrehi 1885 21 intensive intensive JJ cord-335975-m6lkrehi 1885 22 care care NN cord-335975-m6lkrehi 1885 23 unit unit NN cord-335975-m6lkrehi 1885 24 between between IN cord-335975-m6lkrehi 1885 25 January January NNP cord-335975-m6lkrehi 1885 26 and and CC cord-335975-m6lkrehi 1885 27 June June NNP cord-335975-m6lkrehi 1885 28 2017 2017 CD cord-335975-m6lkrehi 1885 29 . . . cord-335975-m6lkrehi 1886 1 Exclusion exclusion NN cord-335975-m6lkrehi 1886 2 criteria criterion NNS cord-335975-m6lkrehi 1886 3 were be VBD cord-335975-m6lkrehi 1886 4 ongoing ongoing JJ cord-335975-m6lkrehi 1886 5 blood blood NN cord-335975-m6lkrehi 1886 6 transfusion transfusion NN cord-335975-m6lkrehi 1886 7 and and CC cord-335975-m6lkrehi 1886 8 blood blood NN cord-335975-m6lkrehi 1886 9 volume volume NN cord-335975-m6lkrehi 1886 10 controled control VBD cord-335975-m6lkrehi 1886 11 ultrafiltration ultrafiltration NNP cord-335975-m6lkrehi 1886 12 . . . cord-335975-m6lkrehi 1887 1 Medical medical JJ cord-335975-m6lkrehi 1887 2 records record NNS cord-335975-m6lkrehi 1887 3 were be VBD cord-335975-m6lkrehi 1887 4 compiled compile VBN cord-335975-m6lkrehi 1887 5 along along IN cord-335975-m6lkrehi 1887 6 with with IN cord-335975-m6lkrehi 1887 7 cardiac cardiac JJ cord-335975-m6lkrehi 1887 8 ultrasonography ultrasonography NN cord-335975-m6lkrehi 1887 9 at at IN cord-335975-m6lkrehi 1887 10 the the DT cord-335975-m6lkrehi 1887 11 beginning beginning NN cord-335975-m6lkrehi 1887 12 when when WRB cord-335975-m6lkrehi 1887 13 available available JJ cord-335975-m6lkrehi 1887 14 . . . cord-335975-m6lkrehi 1888 1 The the DT cord-335975-m6lkrehi 1888 2 statistical statistical JJ cord-335975-m6lkrehi 1888 3 analysis analysis NN cord-335975-m6lkrehi 1888 4 was be VBD cord-335975-m6lkrehi 1888 5 perfomed perfome VBN cord-335975-m6lkrehi 1888 6 in in IN cord-335975-m6lkrehi 1888 7 two two CD cord-335975-m6lkrehi 1888 8 parts part NNS cord-335975-m6lkrehi 1888 9 . . . cord-335975-m6lkrehi 1889 1 The the DT cord-335975-m6lkrehi 1889 2 first first JJ cord-335975-m6lkrehi 1889 3 part part NN cord-335975-m6lkrehi 1889 4 studied study VBD cord-335975-m6lkrehi 1889 5 the the DT cord-335975-m6lkrehi 1889 6 performances performance NNS cord-335975-m6lkrehi 1889 7 of of IN cord-335975-m6lkrehi 1889 8 the the DT cord-335975-m6lkrehi 1889 9 first first JJ cord-335975-m6lkrehi 1889 10 hour hour NN cord-335975-m6lkrehi 1889 11 deltaRBV deltarbv NN cord-335975-m6lkrehi 1889 12 ( ( -LRB- cord-335975-m6lkrehi 1889 13 defined define VBN cord-335975-m6lkrehi 1889 14 by by IN cord-335975-m6lkrehi 1889 15 RBV RBV NNP cord-335975-m6lkrehi 1889 16 before before IN cord-335975-m6lkrehi 1889 17 minus minus NN cord-335975-m6lkrehi 1889 18 RBV RBV NNP cord-335975-m6lkrehi 1889 19 after after IN cord-335975-m6lkrehi 1889 20 1 1 CD cord-335975-m6lkrehi 1889 21 h h NN cord-335975-m6lkrehi 1889 22 of of IN cord-335975-m6lkrehi 1889 23 dialysis dialysis NN cord-335975-m6lkrehi 1889 24 ) ) -RRB- cord-335975-m6lkrehi 1889 25 to to TO cord-335975-m6lkrehi 1889 26 predict predict VB cord-335975-m6lkrehi 1889 27 a a DT cord-335975-m6lkrehi 1889 28 drop drop NN cord-335975-m6lkrehi 1889 29 of of IN cord-335975-m6lkrehi 1889 30 MAP map NN cord-335975-m6lkrehi 1889 31 below below IN cord-335975-m6lkrehi 1889 32 65 65 CD cord-335975-m6lkrehi 1889 33 mmHg mmhg NN cord-335975-m6lkrehi 1889 34 ( ( -LRB- cord-335975-m6lkrehi 1889 35 hypotension hypotension NN cord-335975-m6lkrehi 1889 36 ) ) -RRB- cord-335975-m6lkrehi 1889 37 . . . cord-335975-m6lkrehi 1890 1 This this DT cord-335975-m6lkrehi 1890 2 analysis analysis NN cord-335975-m6lkrehi 1890 3 excluded exclude VBD cord-335975-m6lkrehi 1890 4 sessions session NNS cord-335975-m6lkrehi 1890 5 with with IN cord-335975-m6lkrehi 1890 6 hypotension hypotension NN cord-335975-m6lkrehi 1890 7 and and CC cord-335975-m6lkrehi 1890 8 intervention intervention NN cord-335975-m6lkrehi 1890 9 during during IN cord-335975-m6lkrehi 1890 10 the the DT cord-335975-m6lkrehi 1890 11 first first JJ cord-335975-m6lkrehi 1890 12 hour hour NN cord-335975-m6lkrehi 1890 13 . . . cord-335975-m6lkrehi 1891 1 The the DT cord-335975-m6lkrehi 1891 2 second second JJ cord-335975-m6lkrehi 1891 3 study study NN cord-335975-m6lkrehi 1891 4 was be VBD cord-335975-m6lkrehi 1891 5 the the DT cord-335975-m6lkrehi 1891 6 modelization modelization NN cord-335975-m6lkrehi 1891 7 of of IN cord-335975-m6lkrehi 1891 8 the the DT cord-335975-m6lkrehi 1891 9 relationship relationship NN cord-335975-m6lkrehi 1891 10 between between IN cord-335975-m6lkrehi 1891 11 deltaRBV deltarbv NN cord-335975-m6lkrehi 1891 12 and and CC cord-335975-m6lkrehi 1891 13 deltaMAP deltaMAP NNS cord-335975-m6lkrehi 1891 14 for for IN cord-335975-m6lkrehi 1891 15 every every DT cord-335975-m6lkrehi 1891 16 hour hour NN cord-335975-m6lkrehi 1891 17 of of IN cord-335975-m6lkrehi 1891 18 dialysis dialysis NN cord-335975-m6lkrehi 1891 19 without without IN cord-335975-m6lkrehi 1891 20 any any DT cord-335975-m6lkrehi 1891 21 intervention intervention NN cord-335975-m6lkrehi 1891 22 on on IN cord-335975-m6lkrehi 1891 23 blood blood NN cord-335975-m6lkrehi 1891 24 pressure pressure NN cord-335975-m6lkrehi 1891 25 . . . cord-335975-m6lkrehi 1892 1 Both both DT cord-335975-m6lkrehi 1892 2 analyses analysis NNS cord-335975-m6lkrehi 1892 3 were be VBD cord-335975-m6lkrehi 1892 4 performed perform VBN cord-335975-m6lkrehi 1892 5 using use VBG cord-335975-m6lkrehi 1892 6 mixed mixed JJ cord-335975-m6lkrehi 1892 7 effects effect NNS cord-335975-m6lkrehi 1892 8 linear linear JJ cord-335975-m6lkrehi 1892 9 and and CC cord-335975-m6lkrehi 1892 10 generalized generalized JJ cord-335975-m6lkrehi 1892 11 models model NNS cord-335975-m6lkrehi 1892 12 . . . cord-335975-m6lkrehi 1893 1 Fig fig NN cord-335975-m6lkrehi 1893 2 . . . cord-335975-m6lkrehi 1893 3 1 1 CD cord-335975-m6lkrehi 1893 4 Vancomycin Vancomycin NNP cord-335975-m6lkrehi 1893 5 PK PK NNP cord-335975-m6lkrehi 1893 6 during during IN cord-335975-m6lkrehi 1893 7 SLED SLED NNP cord-335975-m6lkrehi 1893 8 Results result NNS cord-335975-m6lkrehi 1893 9 : : : cord-335975-m6lkrehi 1893 10 A a DT cord-335975-m6lkrehi 1893 11 total total NN cord-335975-m6lkrehi 1893 12 of of IN cord-335975-m6lkrehi 1893 13 82 82 CD cord-335975-m6lkrehi 1893 14 sessions session NNS cord-335975-m6lkrehi 1893 15 on on IN cord-335975-m6lkrehi 1893 16 23 23 CD cord-335975-m6lkrehi 1893 17 different different JJ cord-335975-m6lkrehi 1893 18 patients patient NNS cord-335975-m6lkrehi 1893 19 were be VBD cord-335975-m6lkrehi 1893 20 performed perform VBN cord-335975-m6lkrehi 1893 21 during during IN cord-335975-m6lkrehi 1893 22 the the DT cord-335975-m6lkrehi 1893 23 period period NN cord-335975-m6lkrehi 1893 24 . . . cord-335975-m6lkrehi 1894 1 The the DT cord-335975-m6lkrehi 1894 2 characteristics characteristic NNS cord-335975-m6lkrehi 1894 3 of of IN cord-335975-m6lkrehi 1894 4 patients patient NNS cord-335975-m6lkrehi 1894 5 were be VBD cord-335975-m6lkrehi 1894 6 as as IN cord-335975-m6lkrehi 1894 7 follows follow VBZ cord-335975-m6lkrehi 1894 8 - - HYPH cord-335975-m6lkrehi 1894 9 sex sex NN cord-335975-m6lkrehi 1894 10 ratio ratio NN cord-335975-m6lkrehi 1894 11 at at IN cord-335975-m6lkrehi 1894 12 1 1 CD cord-335975-m6lkrehi 1894 13 , , , cord-335975-m6lkrehi 1894 14 age age NN cord-335975-m6lkrehi 1894 15 ( ( -LRB- cord-335975-m6lkrehi 1894 16 SD sd NN cord-335975-m6lkrehi 1894 17 ) ) -RRB- cord-335975-m6lkrehi 1894 18 64.3 64.3 CD cord-335975-m6lkrehi 1894 19 ( ( -LRB- cord-335975-m6lkrehi 1894 20 9.0 9.0 CD cord-335975-m6lkrehi 1894 21 ) ) -RRB- cord-335975-m6lkrehi 1894 22 , , , cord-335975-m6lkrehi 1894 23 weight weight NN cord-335975-m6lkrehi 1894 24 83.3 83.3 CD cord-335975-m6lkrehi 1894 25 kg kg NNP cord-335975-m6lkrehi 1894 26 ( ( -LRB- cord-335975-m6lkrehi 1894 27 17.2 17.2 CD cord-335975-m6lkrehi 1894 28 ) ) -RRB- cord-335975-m6lkrehi 1894 29 , , , cord-335975-m6lkrehi 1894 30 SAPSII SAPSII NNP cord-335975-m6lkrehi 1894 31 score score VBP cord-335975-m6lkrehi 1894 32 48 48 CD cord-335975-m6lkrehi 1894 33 . . . cord-335975-m6lkrehi 1895 1 3 3 LS cord-335975-m6lkrehi 1895 2 ( ( -LRB- cord-335975-m6lkrehi 1895 3 13.6 13.6 CD cord-335975-m6lkrehi 1895 4 ) ) -RRB- cord-335975-m6lkrehi 1895 5 . . . cord-335975-m6lkrehi 1896 1 20 20 CD cord-335975-m6lkrehi 1896 2 patients patient NNS cord-335975-m6lkrehi 1896 3 on on IN cord-335975-m6lkrehi 1896 4 23 23 CD cord-335975-m6lkrehi 1896 5 were be VBD cord-335975-m6lkrehi 1896 6 taken take VBN cord-335975-m6lkrehi 1896 7 in in IN cord-335975-m6lkrehi 1896 8 charge charge NN cord-335975-m6lkrehi 1896 9 for for IN cord-335975-m6lkrehi 1896 10 fluid fluid JJ cord-335975-m6lkrehi 1896 11 overload overload NN cord-335975-m6lkrehi 1896 12 . . . cord-335975-m6lkrehi 1897 1 In in IN cord-335975-m6lkrehi 1897 2 the the DT cord-335975-m6lkrehi 1897 3 first first JJ cord-335975-m6lkrehi 1897 4 set set NN cord-335975-m6lkrehi 1897 5 of of IN cord-335975-m6lkrehi 1897 6 analyses analysis NNS cord-335975-m6lkrehi 1897 7 ( ( -LRB- cord-335975-m6lkrehi 1897 8 per per IN cord-335975-m6lkrehi 1897 9 sessions session NNS cord-335975-m6lkrehi 1897 10 ) ) -RRB- cord-335975-m6lkrehi 1897 11 , , , cord-335975-m6lkrehi 1897 12 27 27 CD cord-335975-m6lkrehi 1897 13 sessions session NNS cord-335975-m6lkrehi 1897 14 were be VBD cord-335975-m6lkrehi 1897 15 excluded exclude VBN cord-335975-m6lkrehi 1897 16 for for IN cord-335975-m6lkrehi 1897 17 intervention intervention NN cord-335975-m6lkrehi 1897 18 in in IN cord-335975-m6lkrehi 1897 19 the the DT cord-335975-m6lkrehi 1897 20 first first JJ cord-335975-m6lkrehi 1897 21 hour hour NN cord-335975-m6lkrehi 1897 22 . . . cord-335975-m6lkrehi 1898 1 The the DT cord-335975-m6lkrehi 1898 2 adjusted adjusted JJ cord-335975-m6lkrehi 1898 3 DeltaRBV DeltaRBV NNP cord-335975-m6lkrehi 1898 4 did do VBD cord-335975-m6lkrehi 1898 5 not not RB cord-335975-m6lkrehi 1898 6 predict predict VB cord-335975-m6lkrehi 1898 7 hypotension hypotension NN cord-335975-m6lkrehi 1898 8 during during IN cord-335975-m6lkrehi 1898 9 the the DT cord-335975-m6lkrehi 1898 10 session session NN cord-335975-m6lkrehi 1898 11 ( ( -LRB- cord-335975-m6lkrehi 1898 12 generalized generalize VBN cord-335975-m6lkrehi 1898 13 mixed mixed JJ cord-335975-m6lkrehi 1898 14 effect effect NN cord-335975-m6lkrehi 1898 15 model model NN cord-335975-m6lkrehi 1898 16 , , , cord-335975-m6lkrehi 1898 17 session session NN cord-335975-m6lkrehi 1898 18 and and CC cord-335975-m6lkrehi 1898 19 patients patient NNS cord-335975-m6lkrehi 1898 20 set set VBN cord-335975-m6lkrehi 1898 21 as as IN cord-335975-m6lkrehi 1898 22 random random JJ cord-335975-m6lkrehi 1898 23 effects effect NNS cord-335975-m6lkrehi 1898 24 , , , cord-335975-m6lkrehi 1898 25 estimate estimate VB cord-335975-m6lkrehi 1898 26 0.14 0.14 CD cord-335975-m6lkrehi 1898 27 , , , cord-335975-m6lkrehi 1898 28 p p NN cord-335975-m6lkrehi 1898 29 = = SYM cord-335975-m6lkrehi 1898 30 0.71 0.71 CD cord-335975-m6lkrehi 1898 31 ) ) -RRB- cord-335975-m6lkrehi 1898 32 . . . cord-335975-m6lkrehi 1899 1 In in IN cord-335975-m6lkrehi 1899 2 the the DT cord-335975-m6lkrehi 1899 3 second second JJ cord-335975-m6lkrehi 1899 4 set set NN cord-335975-m6lkrehi 1899 5 of of IN cord-335975-m6lkrehi 1899 6 analyses analysis NNS cord-335975-m6lkrehi 1899 7 ( ( -LRB- cord-335975-m6lkrehi 1899 8 per per IN cord-335975-m6lkrehi 1899 9 hour hour NN cord-335975-m6lkrehi 1899 10 without without IN cord-335975-m6lkrehi 1899 11 any any DT cord-335975-m6lkrehi 1899 12 intervention intervention NN cord-335975-m6lkrehi 1899 13 ) ) -RRB- cord-335975-m6lkrehi 1899 14 , , , cord-335975-m6lkrehi 1899 15 535 535 CD cord-335975-m6lkrehi 1899 16 h h NN cord-335975-m6lkrehi 1899 17 were be VBD cord-335975-m6lkrehi 1899 18 analyzed analyze VBN cord-335975-m6lkrehi 1899 19 . . . cord-335975-m6lkrehi 1900 1 Adjusted Adjusted NNP cord-335975-m6lkrehi 1900 2 DeltaRBV DeltaRBV NNP cord-335975-m6lkrehi 1900 3 correlated correlate VBD cord-335975-m6lkrehi 1900 4 strongly strongly RB cord-335975-m6lkrehi 1900 5 and and CC cord-335975-m6lkrehi 1900 6 inversly inversly RB cord-335975-m6lkrehi 1900 7 with with IN cord-335975-m6lkrehi 1900 8 deltaMAP deltamap FW cord-335975-m6lkrehi 1900 9 ( ( -LRB- cord-335975-m6lkrehi 1900 10 linear linear JJ cord-335975-m6lkrehi 1900 11 mixed mixed JJ cord-335975-m6lkrehi 1900 12 effect effect NN cord-335975-m6lkrehi 1900 13 model model NN cord-335975-m6lkrehi 1900 14 , , , cord-335975-m6lkrehi 1900 15 random random JJ cord-335975-m6lkrehi 1900 16 effects effect NNS cord-335975-m6lkrehi 1900 17 were be VBD cord-335975-m6lkrehi 1900 18 sessions session NNS cord-335975-m6lkrehi 1900 19 , , , cord-335975-m6lkrehi 1900 20 patients patient NNS cord-335975-m6lkrehi 1900 21 and and CC cord-335975-m6lkrehi 1900 22 hour hour NN cord-335975-m6lkrehi 1900 23 order order NN cord-335975-m6lkrehi 1900 24 in in IN cord-335975-m6lkrehi 1900 25 the the DT cord-335975-m6lkrehi 1900 26 session session NN cord-335975-m6lkrehi 1900 27 , , , cord-335975-m6lkrehi 1900 28 estimate estimate VBP cord-335975-m6lkrehi 1900 29 1.42 1.42 CD cord-335975-m6lkrehi 1900 30 , , , cord-335975-m6lkrehi 1900 31 p p NN cord-335975-m6lkrehi 1900 32 < < XX cord-335975-m6lkrehi 1900 33 0.0001 0.0001 CD cord-335975-m6lkrehi 1900 34 ) ) -RRB- cord-335975-m6lkrehi 1900 35 . . . cord-335975-m6lkrehi 1901 1 Conclusion conclusion NN cord-335975-m6lkrehi 1901 2 : : : cord-335975-m6lkrehi 1902 1 In in IN cord-335975-m6lkrehi 1902 2 our -PRON- PRP$ cord-335975-m6lkrehi 1902 3 mostly mostly RB cord-335975-m6lkrehi 1902 4 fluid fluid JJ cord-335975-m6lkrehi 1902 5 overloaded overloaded JJ cord-335975-m6lkrehi 1902 6 patients patient NNS cord-335975-m6lkrehi 1902 7 , , , cord-335975-m6lkrehi 1902 8 the the DT cord-335975-m6lkrehi 1902 9 drop drop NN cord-335975-m6lkrehi 1902 10 of of IN cord-335975-m6lkrehi 1902 11 RBV RBV NNP cord-335975-m6lkrehi 1902 12 correlated correlate VBN cord-335975-m6lkrehi 1902 13 with with IN cord-335975-m6lkrehi 1902 14 an an DT cord-335975-m6lkrehi 1902 15 increase increase NN cord-335975-m6lkrehi 1902 16 of of IN cord-335975-m6lkrehi 1902 17 MAP map NN cord-335975-m6lkrehi 1902 18 . . . cord-335975-m6lkrehi 1903 1 Introduction introduction NN cord-335975-m6lkrehi 1903 2 : : : cord-335975-m6lkrehi 1904 1 Kidney kidney NN cord-335975-m6lkrehi 1904 2 transplant transplant NN cord-335975-m6lkrehi 1904 3 recipients recipient NNS cord-335975-m6lkrehi 1904 4 ( ( -LRB- cord-335975-m6lkrehi 1904 5 KTR KTR NNP cord-335975-m6lkrehi 1904 6 ) ) -RRB- cord-335975-m6lkrehi 1904 7 are be VBP cord-335975-m6lkrehi 1904 8 at at IN cord-335975-m6lkrehi 1904 9 risk risk NN cord-335975-m6lkrehi 1904 10 of of IN cord-335975-m6lkrehi 1904 11 ICU ICU NNP cord-335975-m6lkrehi 1904 12 admission admission NN cord-335975-m6lkrehi 1904 13 because because IN cord-335975-m6lkrehi 1904 14 of of IN cord-335975-m6lkrehi 1904 15 prolonged prolonged JJ cord-335975-m6lkrehi 1904 16 immunosuppressive immunosuppressive JJ cord-335975-m6lkrehi 1904 17 therapy therapy NN cord-335975-m6lkrehi 1904 18 and and CC cord-335975-m6lkrehi 1904 19 a a DT cord-335975-m6lkrehi 1904 20 higher high JJR cord-335975-m6lkrehi 1904 21 risk risk NN cord-335975-m6lkrehi 1904 22 of of IN cord-335975-m6lkrehi 1904 23 cardiovascular cardiovascular JJ cord-335975-m6lkrehi 1904 24 events event NNS cord-335975-m6lkrehi 1904 25 , , , cord-335975-m6lkrehi 1904 26 severe severe JJ cord-335975-m6lkrehi 1904 27 infections infection NNS cord-335975-m6lkrehi 1904 28 or or CC cord-335975-m6lkrehi 1904 29 drug drug NN cord-335975-m6lkrehi 1904 30 - - HYPH cord-335975-m6lkrehi 1904 31 related relate VBN cord-335975-m6lkrehi 1904 32 toxicities toxicity NNS cord-335975-m6lkrehi 1904 33 . . . cord-335975-m6lkrehi 1905 1 Several several JJ cord-335975-m6lkrehi 1905 2 retrospectives retrospective NNS cord-335975-m6lkrehi 1905 3 studies study NNS cord-335975-m6lkrehi 1905 4 reported report VBD cord-335975-m6lkrehi 1905 5 the the DT cord-335975-m6lkrehi 1905 6 short short JJ cord-335975-m6lkrehi 1905 7 - - HYPH cord-335975-m6lkrehi 1905 8 term term NN cord-335975-m6lkrehi 1905 9 outcome outcome NN cord-335975-m6lkrehi 1905 10 of of IN cord-335975-m6lkrehi 1905 11 KTR KTR NNP cord-335975-m6lkrehi 1905 12 admitted admit VBD cord-335975-m6lkrehi 1905 13 to to IN cord-335975-m6lkrehi 1905 14 the the DT cord-335975-m6lkrehi 1905 15 ICU ICU NNP cord-335975-m6lkrehi 1905 16 , , , cord-335975-m6lkrehi 1905 17 but but CC cord-335975-m6lkrehi 1905 18 data datum NNS cord-335975-m6lkrehi 1905 19 concerning concern VBG cord-335975-m6lkrehi 1905 20 the the DT cord-335975-m6lkrehi 1905 21 risk risk NN cord-335975-m6lkrehi 1905 22 of of IN cord-335975-m6lkrehi 1905 23 chronic chronic JJ cord-335975-m6lkrehi 1905 24 kidney kidney NN cord-335975-m6lkrehi 1905 25 disease disease NN cord-335975-m6lkrehi 1905 26 and and CC cord-335975-m6lkrehi 1905 27 anti anti JJ cord-335975-m6lkrehi 1905 28 - - JJ cord-335975-m6lkrehi 1905 29 HLA HLA NNP cord-335975-m6lkrehi 1905 30 immunization immunization NN cord-335975-m6lkrehi 1905 31 are be VBP cord-335975-m6lkrehi 1905 32 scarce scarce JJ cord-335975-m6lkrehi 1905 33 . . . cord-335975-m6lkrehi 1906 1 Patients patient NNS cord-335975-m6lkrehi 1906 2 and and CC cord-335975-m6lkrehi 1906 3 methods method NNS cord-335975-m6lkrehi 1906 4 : : : cord-335975-m6lkrehi 1906 5 In in IN cord-335975-m6lkrehi 1906 6 this this DT cord-335975-m6lkrehi 1906 7 retrospective retrospective JJ cord-335975-m6lkrehi 1906 8 study study NN cord-335975-m6lkrehi 1906 9 , , , cord-335975-m6lkrehi 1906 10 we -PRON- PRP cord-335975-m6lkrehi 1906 11 addressed address VBD cord-335975-m6lkrehi 1906 12 the the DT cord-335975-m6lkrehi 1906 13 in in IN cord-335975-m6lkrehi 1906 14 - - HYPH cord-335975-m6lkrehi 1906 15 hospital hospital NN cord-335975-m6lkrehi 1906 16 and and CC cord-335975-m6lkrehi 1906 17 long long JJ cord-335975-m6lkrehi 1906 18 - - HYPH cord-335975-m6lkrehi 1906 19 term term NN cord-335975-m6lkrehi 1906 20 mortalities mortality NNS cord-335975-m6lkrehi 1906 21 of of IN cord-335975-m6lkrehi 1906 22 the the DT cord-335975-m6lkrehi 1906 23 200 200 CD cord-335975-m6lkrehi 1906 24 KTR KTR NNP cord-335975-m6lkrehi 1906 25 admitted admit VBD cord-335975-m6lkrehi 1906 26 in in IN cord-335975-m6lkrehi 1906 27 a a DT cord-335975-m6lkrehi 1906 28 French french JJ cord-335975-m6lkrehi 1906 29 ICU ICU NNP cord-335975-m6lkrehi 1906 30 ( ( -LRB- cord-335975-m6lkrehi 1906 31 10 10 CD cord-335975-m6lkrehi 1906 32 beds bed NNS cord-335975-m6lkrehi 1906 33 ) ) -RRB- cord-335975-m6lkrehi 1906 34 between between IN cord-335975-m6lkrehi 1906 35 January January NNP cord-335975-m6lkrehi 1906 36 2010 2010 CD cord-335975-m6lkrehi 1906 37 and and CC cord-335975-m6lkrehi 1906 38 June June NNP cord-335975-m6lkrehi 1906 39 2016 2016 CD cord-335975-m6lkrehi 1906 40 . . . cord-335975-m6lkrehi 1907 1 Predictive predictive JJ cord-335975-m6lkrehi 1907 2 factors factor NNS cord-335975-m6lkrehi 1907 3 for for IN cord-335975-m6lkrehi 1907 4 death death NN cord-335975-m6lkrehi 1907 5 , , , cord-335975-m6lkrehi 1907 6 long long JJ cord-335975-m6lkrehi 1907 7 - - HYPH cord-335975-m6lkrehi 1907 8 term term NN cord-335975-m6lkrehi 1907 9 renal renal JJ cord-335975-m6lkrehi 1907 10 function function NN cord-335975-m6lkrehi 1907 11 and and CC cord-335975-m6lkrehi 1907 12 HLA HLA NNP cord-335975-m6lkrehi 1907 13 immunization immunization NN cord-335975-m6lkrehi 1907 14 were be VBD cord-335975-m6lkrehi 1907 15 identified identify VBN cord-335975-m6lkrehi 1907 16 . . . cord-335975-m6lkrehi 1908 1 Results result NNS cord-335975-m6lkrehi 1908 2 : : : cord-335975-m6lkrehi 1909 1 The the DT cord-335975-m6lkrehi 1909 2 main main JJ cord-335975-m6lkrehi 1909 3 causes cause NNS cord-335975-m6lkrehi 1909 4 for for IN cord-335975-m6lkrehi 1909 5 admission admission NN cord-335975-m6lkrehi 1909 6 were be VBD cord-335975-m6lkrehi 1909 7 acute acute JJ cord-335975-m6lkrehi 1909 8 respiratory respiratory JJ cord-335975-m6lkrehi 1909 9 failure failure NN cord-335975-m6lkrehi 1909 10 ( ( -LRB- cord-335975-m6lkrehi 1909 11 27.5 27.5 CD cord-335975-m6lkrehi 1909 12 % % NN cord-335975-m6lkrehi 1909 13 ) ) -RRB- cord-335975-m6lkrehi 1909 14 , , , cord-335975-m6lkrehi 1909 15 sepsis sepsis NN cord-335975-m6lkrehi 1909 16 ( ( -LRB- cord-335975-m6lkrehi 1909 17 26.5 26.5 CD cord-335975-m6lkrehi 1909 18 % % NN cord-335975-m6lkrehi 1909 19 ) ) -RRB- cord-335975-m6lkrehi 1909 20 , , , cord-335975-m6lkrehi 1909 21 post post JJ cord-335975-m6lkrehi 1909 22 - - JJ cord-335975-m6lkrehi 1909 23 operative operative JJ cord-335975-m6lkrehi 1909 24 period period NN cord-335975-m6lkrehi 1909 25 ( ( -LRB- cord-335975-m6lkrehi 1909 26 peritonitis peritonitis NN cord-335975-m6lkrehi 1909 27 , , , cord-335975-m6lkrehi 1909 28 hemorrhage hemorrhage NN cord-335975-m6lkrehi 1909 29 + + SYM cord-335975-m6lkrehi 1909 30 23 23 CD cord-335975-m6lkrehi 1909 31 % % NN cord-335975-m6lkrehi 1909 32 ) ) -RRB- cord-335975-m6lkrehi 1909 33 . . . cord-335975-m6lkrehi 1910 1 At at IN cord-335975-m6lkrehi 1910 2 the the DT cord-335975-m6lkrehi 1910 3 admission admission NN cord-335975-m6lkrehi 1910 4 , , , cord-335975-m6lkrehi 1910 5 mean mean JJ cord-335975-m6lkrehi 1910 6 age age NN cord-335975-m6lkrehi 1910 7 , , , cord-335975-m6lkrehi 1910 8 SAPS2 SAPS2 NNP cord-335975-m6lkrehi 1910 9 and and CC cord-335975-m6lkrehi 1910 10 SOFA SOFA NNP cord-335975-m6lkrehi 1910 11 score score NN cord-335975-m6lkrehi 1910 12 were be VBD cord-335975-m6lkrehi 1910 13 58 58 CD cord-335975-m6lkrehi 1910 14 ± ± CD cord-335975-m6lkrehi 1910 15 13 13 CD cord-335975-m6lkrehi 1910 16 years year NNS cord-335975-m6lkrehi 1910 17 , , , cord-335975-m6lkrehi 1910 18 52 52 CD cord-335975-m6lkrehi 1910 19 ± ± CD cord-335975-m6lkrehi 1910 20 19 19 CD cord-335975-m6lkrehi 1910 21 and and CC cord-335975-m6lkrehi 1910 22 6.7 6.7 CD cord-335975-m6lkrehi 1910 23 ± ± NNP cord-335975-m6lkrehi 1910 24 3.3 3.3 CD cord-335975-m6lkrehi 1910 25 , , , cord-335975-m6lkrehi 1910 26 respectively respectively RB cord-335975-m6lkrehi 1910 27 . . . cord-335975-m6lkrehi 1911 1 Renal renal JJ cord-335975-m6lkrehi 1911 2 replacement replacement NN cord-335975-m6lkrehi 1911 3 therapy therapy NN cord-335975-m6lkrehi 1911 4 , , , cord-335975-m6lkrehi 1911 5 mechanical mechanical JJ cord-335975-m6lkrehi 1911 6 ventilation ventilation NN cord-335975-m6lkrehi 1911 7 and and CC cord-335975-m6lkrehi 1911 8 vasopressors vasopressor NNS cord-335975-m6lkrehi 1911 9 were be VBD cord-335975-m6lkrehi 1911 10 required require VBN cord-335975-m6lkrehi 1911 11 in in IN cord-335975-m6lkrehi 1911 12 103 103 CD cord-335975-m6lkrehi 1911 13 ( ( -LRB- cord-335975-m6lkrehi 1911 14 51.5 51.5 CD cord-335975-m6lkrehi 1911 15 % % NN cord-335975-m6lkrehi 1911 16 ) ) -RRB- cord-335975-m6lkrehi 1911 17 , , , cord-335975-m6lkrehi 1911 18 107 107 CD cord-335975-m6lkrehi 1911 19 ( ( -LRB- cord-335975-m6lkrehi 1911 20 53.5 53.5 CD cord-335975-m6lkrehi 1911 21 % % NN cord-335975-m6lkrehi 1911 22 ) ) -RRB- cord-335975-m6lkrehi 1911 23 and and CC cord-335975-m6lkrehi 1911 24 97 97 CD cord-335975-m6lkrehi 1911 25 ( ( -LRB- cord-335975-m6lkrehi 1911 26 48.5 48.5 CD cord-335975-m6lkrehi 1911 27 % % NN cord-335975-m6lkrehi 1911 28 ) ) -RRB- cord-335975-m6lkrehi 1911 29 patients patient NNS cord-335975-m6lkrehi 1911 30 . . . cord-335975-m6lkrehi 1912 1 Immunosuppressive immunosuppressive JJ cord-335975-m6lkrehi 1912 2 regimen regimen NN cord-335975-m6lkrehi 1912 3 was be VBD cord-335975-m6lkrehi 1912 4 modified modify VBN cord-335975-m6lkrehi 1912 5 in in IN cord-335975-m6lkrehi 1912 6 155 155 CD cord-335975-m6lkrehi 1912 7 patients patient NNS cord-335975-m6lkrehi 1912 8 ( ( -LRB- cord-335975-m6lkrehi 1912 9 76.1 76.1 CD cord-335975-m6lkrehi 1912 10 % % NN cord-335975-m6lkrehi 1912 11 + + CC cord-335975-m6lkrehi 1912 12 steroids steroid NNS cord-335975-m6lkrehi 1912 13 increase increase VBP cord-335975-m6lkrehi 1912 14 68 68 CD cord-335975-m6lkrehi 1912 15 % % NN cord-335975-m6lkrehi 1912 16 , , , cord-335975-m6lkrehi 1912 17 calcineurin calcineurin NNP cord-335975-m6lkrehi 1912 18 inhibitors inhibitor NNS cord-335975-m6lkrehi 1912 19 or or CC cord-335975-m6lkrehi 1912 20 antimetabolites antimetabolites NNPS cord-335975-m6lkrehi 1912 21 withdrawal withdrawal NNP cord-335975-m6lkrehi 1912 22 25 25 CD cord-335975-m6lkrehi 1912 23 and and CC cord-335975-m6lkrehi 1912 24 37 37 CD cord-335975-m6lkrehi 1912 25 % % NN cord-335975-m6lkrehi 1912 26 , , , cord-335975-m6lkrehi 1912 27 respectively respectively RB cord-335975-m6lkrehi 1912 28 ) ) -RRB- cord-335975-m6lkrehi 1912 29 . . . cord-335975-m6lkrehi 1913 1 In in IN cord-335975-m6lkrehi 1913 2 - - HYPH cord-335975-m6lkrehi 1913 3 hospital hospital NN cord-335975-m6lkrehi 1913 4 mortality mortality NN cord-335975-m6lkrehi 1913 5 was be VBD cord-335975-m6lkrehi 1913 6 20 20 CD cord-335975-m6lkrehi 1913 7 % % NN cord-335975-m6lkrehi 1913 8 ( ( -LRB- cord-335975-m6lkrehi 1913 9 30.1 30.1 CD cord-335975-m6lkrehi 1913 10 and and CC cord-335975-m6lkrehi 1913 11 38.2 38.2 CD cord-335975-m6lkrehi 1913 12 % % NN cord-335975-m6lkrehi 1913 13 at at IN cord-335975-m6lkrehi 1913 14 months month NNS cord-335975-m6lkrehi 1913 15 12 12 CD cord-335975-m6lkrehi 1913 16 and and CC cord-335975-m6lkrehi 1913 17 36 36 CD cord-335975-m6lkrehi 1913 18 ) ) -RRB- cord-335975-m6lkrehi 1913 19 . . . cord-335975-m6lkrehi 1914 1 By by IN cord-335975-m6lkrehi 1914 2 multivariate multivariate JJ cord-335975-m6lkrehi 1914 3 analysis analysis NN cord-335975-m6lkrehi 1914 4 , , , cord-335975-m6lkrehi 1914 5 EBV EBV NNP cord-335975-m6lkrehi 1914 6 blood blood NN cord-335975-m6lkrehi 1914 7 proliferation proliferation NN cord-335975-m6lkrehi 1914 8 in in IN cord-335975-m6lkrehi 1914 9 the the DT cord-335975-m6lkrehi 1914 10 6 6 CD cord-335975-m6lkrehi 1914 11 months month NNS cord-335975-m6lkrehi 1914 12 preceding precede VBG cord-335975-m6lkrehi 1914 13 the the DT cord-335975-m6lkrehi 1914 14 admission admission NN cord-335975-m6lkrehi 1914 15 in in IN cord-335975-m6lkrehi 1914 16 the the DT cord-335975-m6lkrehi 1914 17 ICU ICU NNP cord-335975-m6lkrehi 1914 18 , , , cord-335975-m6lkrehi 1914 19 and and CC cord-335975-m6lkrehi 1914 20 the the DT cord-335975-m6lkrehi 1914 21 SAPS2 SAPS2 NNP cord-335975-m6lkrehi 1914 22 gravity gravity NN cord-335975-m6lkrehi 1914 23 score score NN cord-335975-m6lkrehi 1914 24 at at IN cord-335975-m6lkrehi 1914 25 admission admission NN cord-335975-m6lkrehi 1914 26 independently independently RB cord-335975-m6lkrehi 1914 27 predicted predict VBD cord-335975-m6lkrehi 1914 28 the the DT cord-335975-m6lkrehi 1914 29 in in IN cord-335975-m6lkrehi 1914 30 - - HYPH cord-335975-m6lkrehi 1914 31 hospital hospital NN cord-335975-m6lkrehi 1914 32 and and CC cord-335975-m6lkrehi 1914 33 long long JJ cord-335975-m6lkrehi 1914 34 - - HYPH cord-335975-m6lkrehi 1914 35 term term NN cord-335975-m6lkrehi 1914 36 mortalities mortality NNS cord-335975-m6lkrehi 1914 37 . . . cord-335975-m6lkrehi 1915 1 Among among IN cord-335975-m6lkrehi 1915 2 the the DT cord-335975-m6lkrehi 1915 3 113 113 CD cord-335975-m6lkrehi 1915 4 patients patient NNS cord-335975-m6lkrehi 1915 5 alive alive JJ cord-335975-m6lkrehi 1915 6 at at IN cord-335975-m6lkrehi 1915 7 month month NN cord-335975-m6lkrehi 1915 8 6 6 CD cord-335975-m6lkrehi 1915 9 after after IN cord-335975-m6lkrehi 1915 10 the the DT cord-335975-m6lkrehi 1915 11 admission admission NN cord-335975-m6lkrehi 1915 12 in in IN cord-335975-m6lkrehi 1915 13 the the DT cord-335975-m6lkrehi 1915 14 ICU ICU NNP cord-335975-m6lkrehi 1915 15 and and CC cord-335975-m6lkrehi 1915 16 with with IN cord-335975-m6lkrehi 1915 17 available available JJ cord-335975-m6lkrehi 1915 18 data datum NNS cord-335975-m6lkrehi 1915 19 , , , cord-335975-m6lkrehi 1915 20 34 34 CD cord-335975-m6lkrehi 1915 21 ( ( -LRB- cord-335975-m6lkrehi 1915 22 30.1 30.1 CD cord-335975-m6lkrehi 1915 23 % % NN cord-335975-m6lkrehi 1915 24 ) ) -RRB- cord-335975-m6lkrehi 1915 25 and and CC cord-335975-m6lkrehi 1915 26 51 51 CD cord-335975-m6lkrehi 1915 27 ( ( -LRB- cord-335975-m6lkrehi 1915 28 45.1 45.1 CD cord-335975-m6lkrehi 1915 29 % % NN cord-335975-m6lkrehi 1915 30 ) ) -RRB- cord-335975-m6lkrehi 1915 31 progressed progress VBD cord-335975-m6lkrehi 1915 32 to to IN cord-335975-m6lkrehi 1915 33 a a DT cord-335975-m6lkrehi 1915 34 more more RBR cord-335975-m6lkrehi 1915 35 severe severe JJ cord-335975-m6lkrehi 1915 36 CKD CKD NNP cord-335975-m6lkrehi 1915 37 stage stage NN cord-335975-m6lkrehi 1915 38 at at IN cord-335975-m6lkrehi 1915 39 months month NNS cord-335975-m6lkrehi 1915 40 1 1 CD cord-335975-m6lkrehi 1915 41 and and CC cord-335975-m6lkrehi 1915 42 6 6 CD cord-335975-m6lkrehi 1915 43 , , , cord-335975-m6lkrehi 1915 44 respectively respectively RB cord-335975-m6lkrehi 1915 45 . . . cord-335975-m6lkrehi 1916 1 Both both DT cord-335975-m6lkrehi 1916 2 , , , cord-335975-m6lkrehi 1916 3 the the DT cord-335975-m6lkrehi 1916 4 severity severity NN cord-335975-m6lkrehi 1916 5 of of IN cord-335975-m6lkrehi 1916 6 the the DT cord-335975-m6lkrehi 1916 7 AKI AKI NNP cord-335975-m6lkrehi 1916 8 and and CC cord-335975-m6lkrehi 1916 9 the the DT cord-335975-m6lkrehi 1916 10 preexisting preexist VBG cord-335975-m6lkrehi 1916 11 CKD CKD NNP cord-335975-m6lkrehi 1916 12 predicted predict VBD cord-335975-m6lkrehi 1916 13 the the DT cord-335975-m6lkrehi 1916 14 risk risk NN cord-335975-m6lkrehi 1916 15 of of IN cord-335975-m6lkrehi 1916 16 progression progression NN cord-335975-m6lkrehi 1916 17 of of IN cord-335975-m6lkrehi 1916 18 the the DT cord-335975-m6lkrehi 1916 19 CKD CKD NNP cord-335975-m6lkrehi 1916 20 . . . cord-335975-m6lkrehi 1917 1 Last last RB cord-335975-m6lkrehi 1917 2 , , , cord-335975-m6lkrehi 1917 3 de de FW cord-335975-m6lkrehi 1917 4 novo novo NNP cord-335975-m6lkrehi 1917 5 anti anti NNP cord-335975-m6lkrehi 1917 6 - - NNP cord-335975-m6lkrehi 1917 7 HLA HLA NNP cord-335975-m6lkrehi 1917 8 immunization immunization NN cord-335975-m6lkrehi 1917 9 at at IN cord-335975-m6lkrehi 1917 10 month month NN cord-335975-m6lkrehi 1917 11 6 6 CD cord-335975-m6lkrehi 1917 12 was be VBD cord-335975-m6lkrehi 1917 13 identified identify VBN cord-335975-m6lkrehi 1917 14 in in IN cord-335975-m6lkrehi 1917 15 18 18 CD cord-335975-m6lkrehi 1917 16 119 119 CD cord-335975-m6lkrehi 1917 17 patients patient NNS cord-335975-m6lkrehi 1917 18 ( ( -LRB- cord-335975-m6lkrehi 1917 19 15.1 15.1 CD cord-335975-m6lkrehi 1917 20 % % NN cord-335975-m6lkrehi 1917 21 , , , cord-335975-m6lkrehi 1917 22 donor donor NN cord-335975-m6lkrehi 1917 23 specific specific JJ cord-335975-m6lkrehi 1917 24 antibodies antibody NNS cord-335975-m6lkrehi 1917 25 11 11 CD cord-335975-m6lkrehi 1917 26 18 18 CD cord-335975-m6lkrehi 1917 27 ( ( -LRB- cord-335975-m6lkrehi 1917 28 61.1 61.1 CD cord-335975-m6lkrehi 1917 29 % % NN cord-335975-m6lkrehi 1917 30 ) ) -RRB- cord-335975-m6lkrehi 1917 31 ) ) -RRB- cord-335975-m6lkrehi 1917 32 and and CC cord-335975-m6lkrehi 1917 33 was be VBD cord-335975-m6lkrehi 1917 34 significantly significantly RB cord-335975-m6lkrehi 1917 35 associated associate VBN cord-335975-m6lkrehi 1917 36 with with IN cord-335975-m6lkrehi 1917 37 the the DT cord-335975-m6lkrehi 1917 38 occurrence occurrence NN cord-335975-m6lkrehi 1917 39 of of IN cord-335975-m6lkrehi 1917 40 acute acute JJ cord-335975-m6lkrehi 1917 41 transplant transplant NN cord-335975-m6lkrehi 1917 42 rejection rejection NN cord-335975-m6lkrehi 1917 43 ( ( -LRB- cord-335975-m6lkrehi 1917 44 p p NN cord-335975-m6lkrehi 1917 45 = = SYM cord-335975-m6lkrehi 1917 46 0.002 0.002 CD cord-335975-m6lkrehi 1917 47 ) ) -RRB- cord-335975-m6lkrehi 1917 48 . . . cord-335975-m6lkrehi 1918 1 In in IN cord-335975-m6lkrehi 1918 2 five five CD cord-335975-m6lkrehi 1918 3 patients patient NNS cord-335975-m6lkrehi 1918 4 who who WP cord-335975-m6lkrehi 1918 5 developed develop VBD cord-335975-m6lkrehi 1918 6 anti anti JJ cord-335975-m6lkrehi 1918 7 - - JJ cord-335975-m6lkrehi 1918 8 HLA HLA NNP cord-335975-m6lkrehi 1918 9 antibodies antibody NNS cord-335975-m6lkrehi 1918 10 , , , cord-335975-m6lkrehi 1918 11 RBC RBC NNP cord-335975-m6lkrehi 1918 12 transfusion transfusion NN cord-335975-m6lkrehi 1918 13 during during IN cord-335975-m6lkrehi 1918 14 the the DT cord-335975-m6lkrehi 1918 15 ICU ICU NNP cord-335975-m6lkrehi 1918 16 stay stay NN cord-335975-m6lkrehi 1918 17 was be VBD cord-335975-m6lkrehi 1918 18 the the DT cord-335975-m6lkrehi 1918 19 only only JJ cord-335975-m6lkrehi 1918 20 immunological immunological JJ cord-335975-m6lkrehi 1918 21 trigger trigger NN cord-335975-m6lkrehi 1918 22 identified identify VBN cord-335975-m6lkrehi 1918 23 . . . cord-335975-m6lkrehi 1919 1 Discussion discussion NN cord-335975-m6lkrehi 1919 2 : : : cord-335975-m6lkrehi 1920 1 Outcome outcome NN cord-335975-m6lkrehi 1920 2 of of IN cord-335975-m6lkrehi 1920 3 KTR KTR NNP cord-335975-m6lkrehi 1920 4 is be VBZ cord-335975-m6lkrehi 1920 5 closed close VBN cord-335975-m6lkrehi 1920 6 to to IN cord-335975-m6lkrehi 1920 7 the the DT cord-335975-m6lkrehi 1920 8 general general JJ cord-335975-m6lkrehi 1920 9 population population NN cord-335975-m6lkrehi 1920 10 admitted admit VBN cord-335975-m6lkrehi 1920 11 in in IN cord-335975-m6lkrehi 1920 12 ICU ICU NNP cord-335975-m6lkrehi 1920 13 and and CC cord-335975-m6lkrehi 1920 14 better well JJR cord-335975-m6lkrehi 1920 15 than than IN cord-335975-m6lkrehi 1920 16 other other JJ cord-335975-m6lkrehi 1920 17 immunocompromised immunocompromised JJ cord-335975-m6lkrehi 1920 18 patient patient JJ cord-335975-m6lkrehi 1920 19 , , , cord-335975-m6lkrehi 1920 20 like like IN cord-335975-m6lkrehi 1920 21 patients patient NNS cord-335975-m6lkrehi 1920 22 from from IN cord-335975-m6lkrehi 1920 23 oncohematology oncohematology NN cord-335975-m6lkrehi 1920 24 . . . cord-335975-m6lkrehi 1921 1 Conclusion conclusion NN cord-335975-m6lkrehi 1921 2 : : : cord-335975-m6lkrehi 1922 1 Worsening worsen VBG cord-335975-m6lkrehi 1922 2 of of IN cord-335975-m6lkrehi 1922 3 the the DT cord-335975-m6lkrehi 1922 4 renal renal JJ cord-335975-m6lkrehi 1922 5 function function NN cord-335975-m6lkrehi 1922 6 and and CC cord-335975-m6lkrehi 1922 7 HLA HLA NNP cord-335975-m6lkrehi 1922 8 immunization immunization NN cord-335975-m6lkrehi 1922 9 are be VBP cord-335975-m6lkrehi 1922 10 frequent frequent JJ cord-335975-m6lkrehi 1922 11 and and CC cord-335975-m6lkrehi 1922 12 may may MD cord-335975-m6lkrehi 1922 13 impact impact VB cord-335975-m6lkrehi 1922 14 mid mid NN cord-335975-m6lkrehi 1922 15 to to IN cord-335975-m6lkrehi 1922 16 long long JJ cord-335975-m6lkrehi 1922 17 - - HYPH cord-335975-m6lkrehi 1922 18 term term NN cord-335975-m6lkrehi 1922 19 prognosis prognosis NN cord-335975-m6lkrehi 1922 20 because because IN cord-335975-m6lkrehi 1922 21 of of IN cord-335975-m6lkrehi 1922 22 the the DT cord-335975-m6lkrehi 1922 23 high high JJ cord-335975-m6lkrehi 1922 24 risk risk NN cord-335975-m6lkrehi 1922 25 of of IN cord-335975-m6lkrehi 1922 26 transplant transplant NN cord-335975-m6lkrehi 1922 27 rejection rejection NN cord-335975-m6lkrehi 1922 28 , , , cord-335975-m6lkrehi 1922 29 end end NN cord-335975-m6lkrehi 1922 30 - - HYPH cord-335975-m6lkrehi 1922 31 stage stage NN cord-335975-m6lkrehi 1922 32 renal renal JJ cord-335975-m6lkrehi 1922 33 disease disease NN cord-335975-m6lkrehi 1922 34 and and CC cord-335975-m6lkrehi 1922 35 further further JJ cord-335975-m6lkrehi 1922 36 transplantation transplantation NN cord-335975-m6lkrehi 1922 37 contraindication contraindication NN cord-335975-m6lkrehi 1922 38 . . . cord-335975-m6lkrehi 1923 1 Introduction introduction NN cord-335975-m6lkrehi 1923 2 : : : cord-335975-m6lkrehi 1924 1 Acute acute JJ cord-335975-m6lkrehi 1924 2 kidney kidney NN cord-335975-m6lkrehi 1924 3 injury injury NN cord-335975-m6lkrehi 1924 4 ( ( -LRB- cord-335975-m6lkrehi 1924 5 AKI AKI NNP cord-335975-m6lkrehi 1924 6 ) ) -RRB- cord-335975-m6lkrehi 1924 7 is be VBZ cord-335975-m6lkrehi 1924 8 associated associate VBN cord-335975-m6lkrehi 1924 9 with with IN cord-335975-m6lkrehi 1924 10 a a DT cord-335975-m6lkrehi 1924 11 poor poor JJ cord-335975-m6lkrehi 1924 12 prognosis prognosis NN cord-335975-m6lkrehi 1924 13 . . . cord-335975-m6lkrehi 1925 1 Although although IN cord-335975-m6lkrehi 1925 2 pulmonary pulmonary JJ cord-335975-m6lkrehi 1925 3 embolism embolism NN cord-335975-m6lkrehi 1925 4 ( ( -LRB- cord-335975-m6lkrehi 1925 5 PE PE NNP cord-335975-m6lkrehi 1925 6 ) ) -RRB- cord-335975-m6lkrehi 1925 7 may may MD cord-335975-m6lkrehi 1925 8 promote promote VB cord-335975-m6lkrehi 1925 9 AKI AKI NNP cord-335975-m6lkrehi 1925 10 through through IN cord-335975-m6lkrehi 1925 11 renal renal JJ cord-335975-m6lkrehi 1925 12 congestion congestion NN cord-335975-m6lkrehi 1925 13 or or CC cord-335975-m6lkrehi 1925 14 hemodynamic hemodynamic JJ cord-335975-m6lkrehi 1925 15 instability instability NN cord-335975-m6lkrehi 1925 16 , , , cord-335975-m6lkrehi 1925 17 its -PRON- PRP$ cord-335975-m6lkrehi 1925 18 frequency frequency NN cord-335975-m6lkrehi 1925 19 as as IN cord-335975-m6lkrehi 1925 20 its -PRON- PRP$ cord-335975-m6lkrehi 1925 21 impact impact NN cord-335975-m6lkrehi 1925 22 on on IN cord-335975-m6lkrehi 1925 23 the the DT cord-335975-m6lkrehi 1925 24 prognosis prognosis NN cord-335975-m6lkrehi 1925 25 of of IN cord-335975-m6lkrehi 1925 26 patients patient NNS cord-335975-m6lkrehi 1925 27 with with IN cord-335975-m6lkrehi 1925 28 acute acute JJ cord-335975-m6lkrehi 1925 29 PE PE NNP cord-335975-m6lkrehi 1925 30 have have VBP cord-335975-m6lkrehi 1925 31 been be VBN cord-335975-m6lkrehi 1925 32 poorly poorly RB cord-335975-m6lkrehi 1925 33 studied study VBN cord-335975-m6lkrehi 1925 34 . . . cord-335975-m6lkrehi 1926 1 Patients patient NNS cord-335975-m6lkrehi 1926 2 and and CC cord-335975-m6lkrehi 1926 3 methods method NNS cord-335975-m6lkrehi 1926 4 : : : cord-335975-m6lkrehi 1926 5 Using use VBG cord-335975-m6lkrehi 1926 6 data datum NNS cord-335975-m6lkrehi 1926 7 from from IN cord-335975-m6lkrehi 1926 8 the the DT cord-335975-m6lkrehi 1926 9 Registro Registro NNP cord-335975-m6lkrehi 1926 10 Informatizado Informatizado NNP cord-335975-m6lkrehi 1926 11 de de FW cord-335975-m6lkrehi 1926 12 la la FW cord-335975-m6lkrehi 1926 13 Enfermedad Enfermedad NNP cord-335975-m6lkrehi 1926 14 TromboEmbolica TromboEmbolica NNP cord-335975-m6lkrehi 1926 15 venosa venosa NNP cord-335975-m6lkrehi 1926 16 ( ( -LRB- cord-335975-m6lkrehi 1926 17 RIETE RIETE NNP cord-335975-m6lkrehi 1926 18 ) ) -RRB- cord-335975-m6lkrehi 1926 19 registry registry NN cord-335975-m6lkrehi 1926 20 , , , cord-335975-m6lkrehi 1926 21 we -PRON- PRP cord-335975-m6lkrehi 1926 22 assessed assess VBD cord-335975-m6lkrehi 1926 23 the the DT cord-335975-m6lkrehi 1926 24 frequency frequency NN cord-335975-m6lkrehi 1926 25 of of IN cord-335975-m6lkrehi 1926 26 AKI AKI NNP cord-335975-m6lkrehi 1926 27 at at IN cord-335975-m6lkrehi 1926 28 baseline baseline NN cord-335975-m6lkrehi 1926 29 , , , cord-335975-m6lkrehi 1926 30 and and CC cord-335975-m6lkrehi 1926 31 its -PRON- PRP$ cord-335975-m6lkrehi 1926 32 influence influence NN cord-335975-m6lkrehi 1926 33 on on IN cord-335975-m6lkrehi 1926 34 the the DT cord-335975-m6lkrehi 1926 35 30-day 30-day CD cord-335975-m6lkrehi 1926 36 mortality mortality NN cord-335975-m6lkrehi 1926 37 rate rate NN cord-335975-m6lkrehi 1926 38 of of IN cord-335975-m6lkrehi 1926 39 patients patient NNS cord-335975-m6lkrehi 1926 40 with with IN cord-335975-m6lkrehi 1926 41 objectively objectively RB cord-335975-m6lkrehi 1926 42 confirmed confirm VBN cord-335975-m6lkrehi 1926 43 PE PE NNP cord-335975-m6lkrehi 1926 44 . . . cord-335975-m6lkrehi 1927 1 AKI AKI NNP cord-335975-m6lkrehi 1927 2 was be VBD cord-335975-m6lkrehi 1927 3 defined define VBN cord-335975-m6lkrehi 1927 4 according accord VBG cord-335975-m6lkrehi 1927 5 to to IN cord-335975-m6lkrehi 1927 6 the the DT cord-335975-m6lkrehi 1927 7 " " `` cord-335975-m6lkrehi 1927 8 Kidney Kidney NNP cord-335975-m6lkrehi 1927 9 Disease Disease NNP cord-335975-m6lkrehi 1927 10 - - HYPH cord-335975-m6lkrehi 1927 11 Improving Improving NNP cord-335975-m6lkrehi 1927 12 Global Global NNP cord-335975-m6lkrehi 1927 13 Outcomes Outcomes NNPS cord-335975-m6lkrehi 1927 14 " " '' cord-335975-m6lkrehi 1927 15 definition definition NN cord-335975-m6lkrehi 1927 16 . . . cord-335975-m6lkrehi 1928 1 We -PRON- PRP cord-335975-m6lkrehi 1928 2 used use VBD cord-335975-m6lkrehi 1928 3 multivariate multivariate JJ cord-335975-m6lkrehi 1928 4 analysis analysis NN cord-335975-m6lkrehi 1928 5 to to TO cord-335975-m6lkrehi 1928 6 assess assess VB cord-335975-m6lkrehi 1928 7 whether whether IN cord-335975-m6lkrehi 1928 8 or or CC cord-335975-m6lkrehi 1928 9 not not RB cord-335975-m6lkrehi 1928 10 the the DT cord-335975-m6lkrehi 1928 11 presence presence NN cord-335975-m6lkrehi 1928 12 of of IN cord-335975-m6lkrehi 1928 13 AKI AKI NNP cord-335975-m6lkrehi 1928 14 independently independently RB cord-335975-m6lkrehi 1928 15 influenced influence VBD cord-335975-m6lkrehi 1928 16 the the DT cord-335975-m6lkrehi 1928 17 risk risk NN cord-335975-m6lkrehi 1928 18 for for IN cord-335975-m6lkrehi 1928 19 30-day 30-day CD cord-335975-m6lkrehi 1928 20 death death NN cord-335975-m6lkrehi 1928 21 . . . cord-335975-m6lkrehi 1929 1 The the DT cord-335975-m6lkrehi 1929 2 study study NN cord-335975-m6lkrehi 1929 3 included include VBD cord-335975-m6lkrehi 1929 4 21,131 21,131 CD cord-335975-m6lkrehi 1929 5 patients patient NNS cord-335975-m6lkrehi 1929 6 with with IN cord-335975-m6lkrehi 1929 7 acute acute JJ cord-335975-m6lkrehi 1929 8 PE PE NNP cord-335975-m6lkrehi 1929 9 , , , cord-335975-m6lkrehi 1929 10 of of IN cord-335975-m6lkrehi 1929 11 whom whom WP cord-335975-m6lkrehi 1929 12 6222 6222 CD cord-335975-m6lkrehi 1929 13 ( ( -LRB- cord-335975-m6lkrehi 1929 14 29.5 29.5 CD cord-335975-m6lkrehi 1929 15 % % NN cord-335975-m6lkrehi 1929 16 ) ) -RRB- cord-335975-m6lkrehi 1929 17 had have VBD cord-335975-m6lkrehi 1929 18 AKI AKI NNP cord-335975-m6lkrehi 1929 19 at at IN cord-335975-m6lkrehi 1929 20 baseline baseline NN cord-335975-m6lkrehi 1929 21 . . . cord-335975-m6lkrehi 1930 1 Of of IN cord-335975-m6lkrehi 1930 2 these these DT cord-335975-m6lkrehi 1930 3 , , , cord-335975-m6lkrehi 1930 4 4385 4385 CD cord-335975-m6lkrehi 1930 5 patients patient NNS cord-335975-m6lkrehi 1930 6 ( ( -LRB- cord-335975-m6lkrehi 1930 7 21 21 CD cord-335975-m6lkrehi 1930 8 % % NN cord-335975-m6lkrehi 1930 9 ) ) -RRB- cord-335975-m6lkrehi 1930 10 were be VBD cord-335975-m6lkrehi 1930 11 in in IN cord-335975-m6lkrehi 1930 12 stage stage NN cord-335975-m6lkrehi 1930 13 1 1 CD cord-335975-m6lkrehi 1930 14 , , , cord-335975-m6lkrehi 1930 15 1385 1385 CD cord-335975-m6lkrehi 1930 16 ( ( -LRB- cord-335975-m6lkrehi 1930 17 6.5 6.5 CD cord-335975-m6lkrehi 1930 18 % % NN cord-335975-m6lkrehi 1930 19 ) ) -RRB- cord-335975-m6lkrehi 1930 20 in in IN cord-335975-m6lkrehi 1930 21 stage stage NN cord-335975-m6lkrehi 1930 22 2 2 CD cord-335975-m6lkrehi 1930 23 and and CC cord-335975-m6lkrehi 1930 24 452 452 CD cord-335975-m6lkrehi 1930 25 ( ( -LRB- cord-335975-m6lkrehi 1930 26 2 2 CD cord-335975-m6lkrehi 1930 27 % % NN cord-335975-m6lkrehi 1930 28 ) ) -RRB- cord-335975-m6lkrehi 1930 29 in in IN cord-335975-m6lkrehi 1930 30 stage stage NN cord-335975-m6lkrehi 1930 31 3 3 CD cord-335975-m6lkrehi 1930 32 . . . cord-335975-m6lkrehi 1931 1 The the DT cord-335975-m6lkrehi 1931 2 proportion proportion NN cord-335975-m6lkrehi 1931 3 of of IN cord-335975-m6lkrehi 1931 4 patients patient NNS cord-335975-m6lkrehi 1931 5 with with IN cord-335975-m6lkrehi 1931 6 high high JJ cord-335975-m6lkrehi 1931 7 - - HYPH cord-335975-m6lkrehi 1931 8 risk risk NN cord-335975-m6lkrehi 1931 9 PE pe NN cord-335975-m6lkrehi 1931 10 in in IN cord-335975-m6lkrehi 1931 11 those those DT cord-335975-m6lkrehi 1931 12 with with IN cord-335975-m6lkrehi 1931 13 no no DT cord-335975-m6lkrehi 1931 14 AKI AKI NNP cord-335975-m6lkrehi 1931 15 , , , cord-335975-m6lkrehi 1931 16 AKI AKI NNP cord-335975-m6lkrehi 1931 17 stage stage NN cord-335975-m6lkrehi 1931 18 1 1 CD cord-335975-m6lkrehi 1931 19 , , , cord-335975-m6lkrehi 1931 20 AKI AKI NNP cord-335975-m6lkrehi 1931 21 stage stage NN cord-335975-m6lkrehi 1931 22 2 2 CD cord-335975-m6lkrehi 1931 23 and and CC cord-335975-m6lkrehi 1931 24 AKI AKI NNP cord-335975-m6lkrehi 1931 25 stage stage NN cord-335975-m6lkrehi 1931 26 3 3 CD cord-335975-m6lkrehi 1931 27 was-2.8 was-2.8 NN cord-335975-m6lkrehi 1931 28 , , , cord-335975-m6lkrehi 1931 29 5.3 5.3 CD cord-335975-m6lkrehi 1931 30 , , , cord-335975-m6lkrehi 1931 31 8.8 8.8 CD cord-335975-m6lkrehi 1931 32 and and CC cord-335975-m6lkrehi 1931 33 12 12 CD cord-335975-m6lkrehi 1931 34 % % NN cord-335975-m6lkrehi 1931 35 , , , cord-335975-m6lkrehi 1931 36 respectively respectively RB cord-335975-m6lkrehi 1932 1 ( ( -LRB- cord-335975-m6lkrehi 1932 2 p p NN cord-335975-m6lkrehi 1932 3 < < XX cord-335975-m6lkrehi 1932 4 0.001 0.001 CD cord-335975-m6lkrehi 1932 5 ) ) -RRB- cord-335975-m6lkrehi 1932 6 . . . cord-335975-m6lkrehi 1933 1 After after IN cord-335975-m6lkrehi 1933 2 30 30 CD cord-335975-m6lkrehi 1933 3 days day NNS cord-335975-m6lkrehi 1933 4 , , , cord-335975-m6lkrehi 1933 5 1236 1236 CD cord-335975-m6lkrehi 1933 6 patients patient NNS cord-335975-m6lkrehi 1933 7 ( ( -LRB- cord-335975-m6lkrehi 1933 8 5.85 5.85 CD cord-335975-m6lkrehi 1933 9 % % NN cord-335975-m6lkrehi 1933 10 ) ) -RRB- cord-335975-m6lkrehi 1933 11 had have VBD cord-335975-m6lkrehi 1933 12 died die VBN cord-335975-m6lkrehi 1933 13 . . . cord-335975-m6lkrehi 1934 1 Overall overall JJ cord-335975-m6lkrehi 1934 2 mortality mortality NN cord-335975-m6lkrehi 1935 1 was-4 was-4 NNP cord-335975-m6lkrehi 1935 2 % % NN cord-335975-m6lkrehi 1935 3 in in IN cord-335975-m6lkrehi 1935 4 patients patient NNS cord-335975-m6lkrehi 1935 5 with with IN cord-335975-m6lkrehi 1935 6 no no DT cord-335975-m6lkrehi 1935 7 AKI AKI NNP cord-335975-m6lkrehi 1935 8 , , , cord-335975-m6lkrehi 1936 1 8.4 8.4 CD cord-335975-m6lkrehi 1936 2 % % NN cord-335975-m6lkrehi 1936 3 in in IN cord-335975-m6lkrehi 1936 4 AKI AKI NNP cord-335975-m6lkrehi 1936 5 stage stage NN cord-335975-m6lkrehi 1936 6 1 1 CD cord-335975-m6lkrehi 1936 7 , , , cord-335975-m6lkrehi 1937 1 14 14 CD cord-335975-m6lkrehi 1937 2 % % NN cord-335975-m6lkrehi 1937 3 in in IN cord-335975-m6lkrehi 1937 4 AKI AKI NNP cord-335975-m6lkrehi 1937 5 stage stage NN cord-335975-m6lkrehi 1937 6 2 2 CD cord-335975-m6lkrehi 1937 7 , , , cord-335975-m6lkrehi 1938 1 17 17 CD cord-335975-m6lkrehi 1938 2 % % NN cord-335975-m6lkrehi 1938 3 in in IN cord-335975-m6lkrehi 1938 4 AKI AKI NNP cord-335975-m6lkrehi 1938 5 stage stage NN cord-335975-m6lkrehi 1938 6 3 3 CD cord-335975-m6lkrehi 1938 7 , , , cord-335975-m6lkrehi 1938 8 all all DT cord-335975-m6lkrehi 1938 9 p p NN cord-335975-m6lkrehi 1938 10 < < XX cord-335975-m6lkrehi 1938 11 0.001 0.001 CD cord-335975-m6lkrehi 1938 12 ) ) -RRB- cord-335975-m6lkrehi 1938 13 . . . cord-335975-m6lkrehi 1939 1 On on IN cord-335975-m6lkrehi 1939 2 multivariable multivariable JJ cord-335975-m6lkrehi 1939 3 analysis analysis NN cord-335975-m6lkrehi 1939 4 , , , cord-335975-m6lkrehi 1939 5 AKI AKI NNP cord-335975-m6lkrehi 1939 6 was be VBD cord-335975-m6lkrehi 1939 7 independently independently RB cord-335975-m6lkrehi 1939 8 associated associate VBN cord-335975-m6lkrehi 1939 9 with with IN cord-335975-m6lkrehi 1939 10 an an DT cord-335975-m6lkrehi 1939 11 increased increase VBN cord-335975-m6lkrehi 1939 12 risk risk NN cord-335975-m6lkrehi 1939 13 of of IN cord-335975-m6lkrehi 1939 14 death death NN cord-335975-m6lkrehi 1939 15 at at IN cord-335975-m6lkrehi 1939 16 30 30 CD cord-335975-m6lkrehi 1939 17 days day NNS cord-335975-m6lkrehi 1939 18 ( ( -LRB- cord-335975-m6lkrehi 1939 19 odds odd NNS cord-335975-m6lkrehi 1939 20 ratio ratio NN cord-335975-m6lkrehi 1939 21 = = SYM cord-335975-m6lkrehi 1939 22 1.25 1.25 CD cord-335975-m6lkrehi 1939 23 + + SYM cord-335975-m6lkrehi 1939 24 95 95 CD cord-335975-m6lkrehi 1939 25 % % NN cord-335975-m6lkrehi 1939 26 CI CI NNP cord-335975-m6lkrehi 1939 27 1.02 1.02 CD cord-335975-m6lkrehi 1939 28 - - HYPH cord-335975-m6lkrehi 1939 29 1.54 1.54 CD cord-335975-m6lkrehi 1939 30 ) ) -RRB- cord-335975-m6lkrehi 1939 31 , , , cord-335975-m6lkrehi 1939 32 after after IN cord-335975-m6lkrehi 1939 33 adjusting adjust VBG cord-335975-m6lkrehi 1939 34 for for IN cord-335975-m6lkrehi 1939 35 the the DT cord-335975-m6lkrehi 1939 36 initial initial JJ cord-335975-m6lkrehi 1939 37 severity severity NN cord-335975-m6lkrehi 1939 38 of of IN cord-335975-m6lkrehi 1939 39 PE PE NNP cord-335975-m6lkrehi 1939 40 , , , cord-335975-m6lkrehi 1939 41 age age NN cord-335975-m6lkrehi 1939 42 > > XX cord-335975-m6lkrehi 1939 43 65 65 CD cord-335975-m6lkrehi 1939 44 years year NNS cord-335975-m6lkrehi 1939 45 , , , cord-335975-m6lkrehi 1939 46 chronic chronic JJ cord-335975-m6lkrehi 1939 47 heart heart NN cord-335975-m6lkrehi 1939 48 failure failure NN cord-335975-m6lkrehi 1939 49 or or CC cord-335975-m6lkrehi 1939 50 chronic chronic JJ cord-335975-m6lkrehi 1939 51 lung lung NN cord-335975-m6lkrehi 1939 52 disease disease NN cord-335975-m6lkrehi 1939 53 , , , cord-335975-m6lkrehi 1939 54 cancer cancer NN cord-335975-m6lkrehi 1939 55 , , , cord-335975-m6lkrehi 1939 56 anemia anemia NN cord-335975-m6lkrehi 1939 57 and and CC cord-335975-m6lkrehi 1939 58 liver liver NN cord-335975-m6lkrehi 1939 59 cirrhosis cirrhosis NN cord-335975-m6lkrehi 1939 60 . . . cord-335975-m6lkrehi 1940 1 Conclusion conclusion NN cord-335975-m6lkrehi 1940 2 : : : cord-335975-m6lkrehi 1940 3 One one CD cord-335975-m6lkrehi 1940 4 in in IN cord-335975-m6lkrehi 1940 5 every every DT cord-335975-m6lkrehi 1940 6 3 3 CD cord-335975-m6lkrehi 1940 7 - - SYM cord-335975-m6lkrehi 1940 8 4 4 CD cord-335975-m6lkrehi 1940 9 patients patient NNS cord-335975-m6lkrehi 1940 10 with with IN cord-335975-m6lkrehi 1940 11 acute acute JJ cord-335975-m6lkrehi 1940 12 PE PE NNP cord-335975-m6lkrehi 1940 13 had have VBD cord-335975-m6lkrehi 1940 14 AKI AKI NNP cord-335975-m6lkrehi 1940 15 . . . cord-335975-m6lkrehi 1941 1 Moreover moreover RB cord-335975-m6lkrehi 1941 2 AKI AKI NNP cord-335975-m6lkrehi 1941 3 was be VBD cord-335975-m6lkrehi 1941 4 an an DT cord-335975-m6lkrehi 1941 5 independent independent JJ cord-335975-m6lkrehi 1941 6 predictor predictor NN cord-335975-m6lkrehi 1941 7 of of IN cord-335975-m6lkrehi 1941 8 poor poor JJ cord-335975-m6lkrehi 1941 9 outcome outcome NN cord-335975-m6lkrehi 1941 10 in in IN cord-335975-m6lkrehi 1941 11 PE PE NNP cord-335975-m6lkrehi 1941 12 patients patient NNS cord-335975-m6lkrehi 1941 13 . . . cord-335975-m6lkrehi 1942 1 This this DT cord-335975-m6lkrehi 1942 2 study study NN cord-335975-m6lkrehi 1942 3 suggests suggest VBZ cord-335975-m6lkrehi 1942 4 that that IN cord-335975-m6lkrehi 1942 5 PE PE NNP cord-335975-m6lkrehi 1942 6 ( ( -LRB- cord-335975-m6lkrehi 1942 7 and and CC cord-335975-m6lkrehi 1942 8 its -PRON- PRP$ cord-335975-m6lkrehi 1942 9 severity severity NN cord-335975-m6lkrehi 1942 10 ) ) -RRB- cord-335975-m6lkrehi 1942 11 should should MD cord-335975-m6lkrehi 1942 12 be be VB cord-335975-m6lkrehi 1942 13 considered consider VBN cord-335975-m6lkrehi 1942 14 as as IN cord-335975-m6lkrehi 1942 15 a a DT cord-335975-m6lkrehi 1942 16 risk risk NN cord-335975-m6lkrehi 1942 17 factor factor NN cord-335975-m6lkrehi 1942 18 for for IN cord-335975-m6lkrehi 1942 19 AKI AKI NNP cord-335975-m6lkrehi 1942 20 and and CC cord-335975-m6lkrehi 1942 21 AKI AKI NNP cord-335975-m6lkrehi 1942 22 may may MD cord-335975-m6lkrehi 1942 23 deserve deserve VB cord-335975-m6lkrehi 1942 24 to to TO cord-335975-m6lkrehi 1942 25 be be VB cord-335975-m6lkrehi 1942 26 evaluated evaluate VBN cord-335975-m6lkrehi 1942 27 as as IN cord-335975-m6lkrehi 1942 28 a a DT cord-335975-m6lkrehi 1942 29 prognostic prognostic JJ cord-335975-m6lkrehi 1942 30 factor factor NN cord-335975-m6lkrehi 1942 31 in in IN cord-335975-m6lkrehi 1942 32 patients patient NNS cord-335975-m6lkrehi 1942 33 with with IN cord-335975-m6lkrehi 1942 34 acute acute JJ cord-335975-m6lkrehi 1942 35 PE pe NN cord-335975-m6lkrehi 1942 36 . . . cord-335975-m6lkrehi 1943 1 Introduction introduction NN cord-335975-m6lkrehi 1943 2 : : : cord-335975-m6lkrehi 1944 1 Metabolic metabolic JJ cord-335975-m6lkrehi 1944 2 acidosis acidosis NN cord-335975-m6lkrehi 1944 3 is be VBZ cord-335975-m6lkrehi 1944 4 frequently frequently RB cord-335975-m6lkrehi 1944 5 observed observe VBN cord-335975-m6lkrehi 1944 6 as as IN cord-335975-m6lkrehi 1944 7 a a DT cord-335975-m6lkrehi 1944 8 consequence consequence NN cord-335975-m6lkrehi 1944 9 of of IN cord-335975-m6lkrehi 1944 10 global global JJ cord-335975-m6lkrehi 1944 11 ischemia ischemia NN cord-335975-m6lkrehi 1944 12 - - HYPH cord-335975-m6lkrehi 1944 13 reperfusion reperfusion NN cord-335975-m6lkrehi 1944 14 after after IN cord-335975-m6lkrehi 1944 15 out out NN cord-335975-m6lkrehi 1944 16 - - HYPH cord-335975-m6lkrehi 1944 17 of of IN cord-335975-m6lkrehi 1944 18 - - HYPH cord-335975-m6lkrehi 1944 19 hospital hospital NN cord-335975-m6lkrehi 1944 20 cardiac cardiac JJ cord-335975-m6lkrehi 1944 21 arrest arrest NN cord-335975-m6lkrehi 1944 22 ( ( -LRB- cord-335975-m6lkrehi 1944 23 OHCA OHCA NNP cord-335975-m6lkrehi 1944 24 ) ) -RRB- cord-335975-m6lkrehi 1944 25 . . . cord-335975-m6lkrehi 1945 1 We -PRON- PRP cord-335975-m6lkrehi 1945 2 aimed aim VBD cord-335975-m6lkrehi 1945 3 to to TO cord-335975-m6lkrehi 1945 4 identify identify VB cord-335975-m6lkrehi 1945 5 risk risk NN cord-335975-m6lkrehi 1945 6 factors factor NNS cord-335975-m6lkrehi 1945 7 and and CC cord-335975-m6lkrehi 1945 8 assessing assess VBG cord-335975-m6lkrehi 1945 9 the the DT cord-335975-m6lkrehi 1945 10 impact impact NN cord-335975-m6lkrehi 1945 11 of of IN cord-335975-m6lkrehi 1945 12 metabolic metabolic JJ cord-335975-m6lkrehi 1945 13 acidosis acidosis NN cord-335975-m6lkrehi 1945 14 on on IN cord-335975-m6lkrehi 1945 15 outcome outcome NN cord-335975-m6lkrehi 1945 16 after after IN cord-335975-m6lkrehi 1945 17 OHCA OHCA NNP cord-335975-m6lkrehi 1945 18 . . . cord-335975-m6lkrehi 1946 1 Patients patient NNS cord-335975-m6lkrehi 1946 2 and and CC cord-335975-m6lkrehi 1946 3 methods method NNS cord-335975-m6lkrehi 1947 1 : : : cord-335975-m6lkrehi 1947 2 We -PRON- PRP cord-335975-m6lkrehi 1947 3 included include VBD cord-335975-m6lkrehi 1947 4 all all DT cord-335975-m6lkrehi 1947 5 consecutive consecutive JJ cord-335975-m6lkrehi 1947 6 OHCA OHCA NNP cord-335975-m6lkrehi 1947 7 patients patient NNS cord-335975-m6lkrehi 1947 8 admitted admit VBN cord-335975-m6lkrehi 1947 9 between between IN cord-335975-m6lkrehi 1947 10 2007 2007 CD cord-335975-m6lkrehi 1947 11 and and CC cord-335975-m6lkrehi 1947 12 2012 2012 CD cord-335975-m6lkrehi 1947 13 . . . cord-335975-m6lkrehi 1948 1 Using use VBG cord-335975-m6lkrehi 1948 2 admission admission NN cord-335975-m6lkrehi 1948 3 data datum NNS cord-335975-m6lkrehi 1948 4 , , , cord-335975-m6lkrehi 1948 5 metabolic metabolic JJ cord-335975-m6lkrehi 1948 6 acidosis acidosis NN cord-335975-m6lkrehi 1948 7 was be VBD cord-335975-m6lkrehi 1948 8 defined define VBN cord-335975-m6lkrehi 1948 9 by by IN cord-335975-m6lkrehi 1948 10 a a DT cord-335975-m6lkrehi 1948 11 positive positive JJ cord-335975-m6lkrehi 1948 12 base base NN cord-335975-m6lkrehi 1948 13 deficit deficit NN cord-335975-m6lkrehi 1948 14 and and CC cord-335975-m6lkrehi 1948 15 was be VBD cord-335975-m6lkrehi 1948 16 categorized categorize VBN cord-335975-m6lkrehi 1948 17 by by IN cord-335975-m6lkrehi 1948 18 quartiles quartile NNS cord-335975-m6lkrehi 1948 19 . . . cord-335975-m6lkrehi 1949 1 Main main JJ cord-335975-m6lkrehi 1949 2 outcome outcome NN cord-335975-m6lkrehi 1949 3 was be VBD cord-335975-m6lkrehi 1949 4 survival survival NN cord-335975-m6lkrehi 1949 5 at at IN cord-335975-m6lkrehi 1949 6 ICU ICU NNP cord-335975-m6lkrehi 1949 7 discharge discharge NN cord-335975-m6lkrehi 1949 8 . . . cord-335975-m6lkrehi 1950 1 Factors factor NNS cord-335975-m6lkrehi 1950 2 associated associate VBN cord-335975-m6lkrehi 1950 3 with with IN cord-335975-m6lkrehi 1950 4 acidosis acidosis NN cord-335975-m6lkrehi 1950 5 severity severity NN cord-335975-m6lkrehi 1950 6 and and CC cord-335975-m6lkrehi 1950 7 with with IN cord-335975-m6lkrehi 1950 8 main main JJ cord-335975-m6lkrehi 1950 9 outcome outcome NN cord-335975-m6lkrehi 1950 10 were be VBD cord-335975-m6lkrehi 1950 11 evaluated evaluate VBN cord-335975-m6lkrehi 1950 12 by by IN cord-335975-m6lkrehi 1950 13 linear linear JJ cord-335975-m6lkrehi 1950 14 and and CC cord-335975-m6lkrehi 1950 15 logistic logistic JJ cord-335975-m6lkrehi 1950 16 regression regression NN cord-335975-m6lkrehi 1950 17 , , , cord-335975-m6lkrehi 1950 18 respectively respectively RB cord-335975-m6lkrehi 1950 19 . . . cord-335975-m6lkrehi 1951 1 Results result NNS cord-335975-m6lkrehi 1951 2 : : : cord-335975-m6lkrehi 1952 1 826 826 CD cord-335975-m6lkrehi 1952 2 patients patient NNS cord-335975-m6lkrehi 1952 3 ( ( -LRB- cord-335975-m6lkrehi 1952 4 68.3 68.3 CD cord-335975-m6lkrehi 1952 5 % % NN cord-335975-m6lkrehi 1952 6 male male NN cord-335975-m6lkrehi 1952 7 , , , cord-335975-m6lkrehi 1952 8 median median JJ cord-335975-m6lkrehi 1952 9 age age NN cord-335975-m6lkrehi 1952 10 61 61 CD cord-335975-m6lkrehi 1952 11 years year NNS cord-335975-m6lkrehi 1952 12 ) ) -RRB- cord-335975-m6lkrehi 1952 13 were be VBD cord-335975-m6lkrehi 1952 14 included include VBN cord-335975-m6lkrehi 1952 15 in in IN cord-335975-m6lkrehi 1952 16 the the DT cord-335975-m6lkrehi 1952 17 analysis analysis NN cord-335975-m6lkrehi 1952 18 . . . cord-335975-m6lkrehi 1953 1 Median median JJ cord-335975-m6lkrehi 1953 2 base base NN cord-335975-m6lkrehi 1953 3 deficit deficit NN cord-335975-m6lkrehi 1953 4 was be VBD cord-335975-m6lkrehi 1953 5 8.8 8.8 CD cord-335975-m6lkrehi 1953 6 [ [ -LRB- cord-335975-m6lkrehi 1953 7 5.3 5.3 CD cord-335975-m6lkrehi 1953 8 , , , cord-335975-m6lkrehi 1953 9 13.2 13.2 CD cord-335975-m6lkrehi 1953 10 ] ] -RRB- cord-335975-m6lkrehi 1953 11 mEq mEq NNS cord-335975-m6lkrehi 1953 12 / / SYM cord-335975-m6lkrehi 1953 13 l l NN cord-335975-m6lkrehi 1953 14 . . . cord-335975-m6lkrehi 1954 1 Male male JJ cord-335975-m6lkrehi 1954 2 gender gender NN cord-335975-m6lkrehi 1955 1 ( ( -LRB- cord-335975-m6lkrehi 1955 2 p p NN cord-335975-m6lkrehi 1955 3 = = SYM cord-335975-m6lkrehi 1955 4 0.002 0.002 CD cord-335975-m6lkrehi 1955 5 ) ) -RRB- cord-335975-m6lkrehi 1955 6 , , , cord-335975-m6lkrehi 1955 7 resuscitation resuscitation NN cord-335975-m6lkrehi 1955 8 duration duration NN cord-335975-m6lkrehi 1955 9 ( ( -LRB- cord-335975-m6lkrehi 1955 10 p p NN cord-335975-m6lkrehi 1955 11 < < XX cord-335975-m6lkrehi 1955 12 0.001 0.001 CD cord-335975-m6lkrehi 1955 13 ) ) -RRB- cord-335975-m6lkrehi 1955 14 , , , cord-335975-m6lkrehi 1955 15 initial initial JJ cord-335975-m6lkrehi 1955 16 shockable shockable JJ cord-335975-m6lkrehi 1955 17 rhythm rhythm NN cord-335975-m6lkrehi 1955 18 ( ( -LRB- cord-335975-m6lkrehi 1955 19 p p NN cord-335975-m6lkrehi 1955 20 < < XX cord-335975-m6lkrehi 1955 21 0.001 0.001 CD cord-335975-m6lkrehi 1955 22 ) ) -RRB- cord-335975-m6lkrehi 1955 23 and and CC cord-335975-m6lkrehi 1955 24 post post JJ cord-335975-m6lkrehi 1955 25 - - JJ cord-335975-m6lkrehi 1955 26 resuscitation resuscitation JJ cord-335975-m6lkrehi 1955 27 shock shock NN cord-335975-m6lkrehi 1955 28 ( ( -LRB- cord-335975-m6lkrehi 1955 29 p p NN cord-335975-m6lkrehi 1955 30 < < XX cord-335975-m6lkrehi 1955 31 0.001 0.001 CD cord-335975-m6lkrehi 1955 32 ) ) -RRB- cord-335975-m6lkrehi 1955 33 were be VBD cord-335975-m6lkrehi 1955 34 associated associate VBN cord-335975-m6lkrehi 1955 35 with with IN cord-335975-m6lkrehi 1955 36 a a DT cord-335975-m6lkrehi 1955 37 deeper deep JJR cord-335975-m6lkrehi 1955 38 acidosis acidosis NN cord-335975-m6lkrehi 1955 39 . . . cord-335975-m6lkrehi 1956 1 ICU ICU NNP cord-335975-m6lkrehi 1956 2 mortality mortality NN cord-335975-m6lkrehi 1956 3 rate rate NN cord-335975-m6lkrehi 1956 4 increased increase VBD cord-335975-m6lkrehi 1956 5 across across IN cord-335975-m6lkrehi 1956 6 base base JJ cord-335975-m6lkrehi 1956 7 deficit deficit NN cord-335975-m6lkrehi 1956 8 quartiles quartile NNS cord-335975-m6lkrehi 1956 9 ( ( -LRB- cord-335975-m6lkrehi 1956 10 39 39 CD cord-335975-m6lkrehi 1956 11 . . . cord-335975-m6lkrehi 1956 12 1 1 CD cord-335975-m6lkrehi 1956 13 , , , cord-335975-m6lkrehi 1956 14 59.2 59.2 CD cord-335975-m6lkrehi 1956 15 , , , cord-335975-m6lkrehi 1956 16 76.3 76.3 CD cord-335975-m6lkrehi 1956 17 and and CC cord-335975-m6lkrehi 1956 18 88 88 CD cord-335975-m6lkrehi 1956 19 .3 .3 CD cord-335975-m6lkrehi 1956 20 % % NN cord-335975-m6lkrehi 1956 21 , , , cord-335975-m6lkrehi 1956 22 p p NN cord-335975-m6lkrehi 1956 23 for for IN cord-335975-m6lkrehi 1956 24 trend trend NN cord-335975-m6lkrehi 1956 25 < < XX cord-335975-m6lkrehi 1956 26 0.001 0.001 CD cord-335975-m6lkrehi 1956 27 ) ) -RRB- cord-335975-m6lkrehi 1956 28 and and CC cord-335975-m6lkrehi 1956 29 base base NN cord-335975-m6lkrehi 1956 30 deficit deficit NN cord-335975-m6lkrehi 1956 31 was be VBD cord-335975-m6lkrehi 1956 32 independently independently RB cord-335975-m6lkrehi 1956 33 associated associate VBN cord-335975-m6lkrehi 1956 34 with with IN cord-335975-m6lkrehi 1956 35 ICU ICU NNP cord-335975-m6lkrehi 1956 36 mortality mortality NN cord-335975-m6lkrehi 1956 37 ( ( -LRB- cord-335975-m6lkrehi 1956 38 p p NN cord-335975-m6lkrehi 1956 39 < < XX cord-335975-m6lkrehi 1956 40 0.001 0.001 CD cord-335975-m6lkrehi 1956 41 ) ) -RRB- cord-335975-m6lkrehi 1956 42 . . . cord-335975-m6lkrehi 1957 1 The the DT cord-335975-m6lkrehi 1957 2 proportion proportion NN cord-335975-m6lkrehi 1957 3 of of IN cord-335975-m6lkrehi 1957 4 CPC CPC NNP cord-335975-m6lkrehi 1957 5 1 1 CD cord-335975-m6lkrehi 1957 6 patients patient NNS cord-335975-m6lkrehi 1957 7 among among IN cord-335975-m6lkrehi 1957 8 ICU ICU NNP cord-335975-m6lkrehi 1957 9 survivors survivor NNS cord-335975-m6lkrehi 1957 10 was be VBD cord-335975-m6lkrehi 1957 11 similar similar JJ cord-335975-m6lkrehi 1957 12 across across IN cord-335975-m6lkrehi 1957 13 base base JJ cord-335975-m6lkrehi 1957 14 deficit deficit NN cord-335975-m6lkrehi 1957 15 quartiles quartile NNS cord-335975-m6lkrehi 1957 16 ( ( -LRB- cord-335975-m6lkrehi 1957 17 72.8 72.8 CD cord-335975-m6lkrehi 1957 18 , , , cord-335975-m6lkrehi 1957 19 67.1 67.1 CD cord-335975-m6lkrehi 1957 20 , , , cord-335975-m6lkrehi 1957 21 70.5 70.5 CD cord-335975-m6lkrehi 1957 22 and and CC cord-335975-m6lkrehi 1957 23 62.5 62.5 CD cord-335975-m6lkrehi 1957 24 % % NN cord-335975-m6lkrehi 1957 25 , , , cord-335975-m6lkrehi 1957 26 p p NN cord-335975-m6lkrehi 1957 27 = = SYM cord-335975-m6lkrehi 1957 28 0.21 0.21 CD cord-335975-m6lkrehi 1957 29 ) ) -RRB- cord-335975-m6lkrehi 1957 30 and and CC cord-335975-m6lkrehi 1957 31 11.7 11.7 CD cord-335975-m6lkrehi 1957 32 % % NN cord-335975-m6lkrehi 1957 33 of of IN cord-335975-m6lkrehi 1957 34 patients patient NNS cord-335975-m6lkrehi 1957 35 with with IN cord-335975-m6lkrehi 1957 36 a a DT cord-335975-m6lkrehi 1957 37 base base NN cord-335975-m6lkrehi 1957 38 deficit deficit NN cord-335975-m6lkrehi 1957 39 higher high JJR cord-335975-m6lkrehi 1957 40 than than IN cord-335975-m6lkrehi 1957 41 13.2 13.2 CD cord-335975-m6lkrehi 1957 42 mEq mEq NNS cord-335975-m6lkrehi 1957 43 l l NNP cord-335975-m6lkrehi 1957 44 survived survive VBD cord-335975-m6lkrehi 1957 45 to to IN cord-335975-m6lkrehi 1957 46 ICU ICU NNP cord-335975-m6lkrehi 1957 47 discharge discharge NN cord-335975-m6lkrehi 1957 48 with with IN cord-335975-m6lkrehi 1957 49 a a DT cord-335975-m6lkrehi 1957 50 good good JJ cord-335975-m6lkrehi 1957 51 neurological neurological JJ cord-335975-m6lkrehi 1957 52 recovery recovery NN cord-335975-m6lkrehi 1957 53 . . . cord-335975-m6lkrehi 1958 1 Severe severe JJ cord-335975-m6lkrehi 1958 2 metabolic metabolic JJ cord-335975-m6lkrehi 1958 3 acidosis acidosis NN cord-335975-m6lkrehi 1958 4 is be VBZ cord-335975-m6lkrehi 1958 5 frequent frequent JJ cord-335975-m6lkrehi 1958 6 in in IN cord-335975-m6lkrehi 1958 7 OHCA OHCA NNP cord-335975-m6lkrehi 1958 8 patients patient NNS cord-335975-m6lkrehi 1958 9 and and CC cord-335975-m6lkrehi 1958 10 is be VBZ cord-335975-m6lkrehi 1958 11 associated associate VBN cord-335975-m6lkrehi 1958 12 with with IN cord-335975-m6lkrehi 1958 13 poorer poor JJR cord-335975-m6lkrehi 1958 14 outcome outcome NN cord-335975-m6lkrehi 1958 15 , , , cord-335975-m6lkrehi 1958 16 in in IN cord-335975-m6lkrehi 1958 17 particular particular JJ cord-335975-m6lkrehi 1958 18 due due IN cord-335975-m6lkrehi 1958 19 to to IN cord-335975-m6lkrehi 1958 20 refractory refractory JJ cord-335975-m6lkrehi 1958 21 shock shock NN cord-335975-m6lkrehi 1958 22 . . . cord-335975-m6lkrehi 1959 1 However however RB cord-335975-m6lkrehi 1959 2 , , , cord-335975-m6lkrehi 1959 3 we -PRON- PRP cord-335975-m6lkrehi 1959 4 observed observe VBD cord-335975-m6lkrehi 1959 5 that that IN cord-335975-m6lkrehi 1959 6 about about IN cord-335975-m6lkrehi 1959 7 10 10 CD cord-335975-m6lkrehi 1959 8 % % NN cord-335975-m6lkrehi 1959 9 of of IN cord-335975-m6lkrehi 1959 10 patients patient NNS cord-335975-m6lkrehi 1959 11 with with IN cord-335975-m6lkrehi 1959 12 a a DT cord-335975-m6lkrehi 1959 13 very very RB cord-335975-m6lkrehi 1959 14 severe severe JJ cord-335975-m6lkrehi 1959 15 metabolic metabolic JJ cord-335975-m6lkrehi 1959 16 acidosis acidosis NN cord-335975-m6lkrehi 1959 17 survived survive VBD cord-335975-m6lkrehi 1959 18 to to IN cord-335975-m6lkrehi 1959 19 ICU ICU NNP cord-335975-m6lkrehi 1959 20 discharge discharge NN cord-335975-m6lkrehi 1959 21 with with IN cord-335975-m6lkrehi 1959 22 a a DT cord-335975-m6lkrehi 1959 23 good good JJ cord-335975-m6lkrehi 1959 24 neurological neurological JJ cord-335975-m6lkrehi 1959 25 recovery recovery NN cord-335975-m6lkrehi 1959 26 . . . cord-335975-m6lkrehi 1960 1 Introduction introduction NN cord-335975-m6lkrehi 1960 2 : : : cord-335975-m6lkrehi 1960 3 Precarious precarious JJ cord-335975-m6lkrehi 1960 4 socio socio JJ cord-335975-m6lkrehi 1960 5 - - HYPH cord-335975-m6lkrehi 1960 6 economic economic JJ cord-335975-m6lkrehi 1960 7 status status NN cord-335975-m6lkrehi 1960 8 can can MD cord-335975-m6lkrehi 1960 9 directly directly RB cord-335975-m6lkrehi 1960 10 influence influence VB cord-335975-m6lkrehi 1960 11 health health NN cord-335975-m6lkrehi 1960 12 , , , cord-335975-m6lkrehi 1960 13 need need VB cord-335975-m6lkrehi 1960 14 for for IN cord-335975-m6lkrehi 1960 15 hospitalisation hospitalisation NN cord-335975-m6lkrehi 1960 16 and and CC cord-335975-m6lkrehi 1960 17 mortality mortality NN cord-335975-m6lkrehi 1960 18 , , , cord-335975-m6lkrehi 1960 19 according accord VBG cord-335975-m6lkrehi 1960 20 to to IN cord-335975-m6lkrehi 1960 21 a a DT cord-335975-m6lkrehi 1960 22 previous previous JJ cord-335975-m6lkrehi 1960 23 study study NN cord-335975-m6lkrehi 1960 24 performed perform VBN cord-335975-m6lkrehi 1960 25 in in IN cord-335975-m6lkrehi 1960 26 22 22 CD cord-335975-m6lkrehi 1960 27 European european JJ cord-335975-m6lkrehi 1960 28 countries country NNS cord-335975-m6lkrehi 1960 29 . . . cord-335975-m6lkrehi 1961 1 Similar similar JJ cord-335975-m6lkrehi 1961 2 findings finding NNS cord-335975-m6lkrehi 1961 3 have have VBP cord-335975-m6lkrehi 1961 4 been be VBN cord-335975-m6lkrehi 1961 5 reported report VBN cord-335975-m6lkrehi 1961 6 from from IN cord-335975-m6lkrehi 1961 7 Anglo anglo JJ cord-335975-m6lkrehi 1961 8 - - HYPH cord-335975-m6lkrehi 1961 9 Saxon saxon JJ cord-335975-m6lkrehi 1961 10 countries country NNS cord-335975-m6lkrehi 1961 11 in in IN cord-335975-m6lkrehi 1961 12 the the DT cord-335975-m6lkrehi 1961 13 setting setting NN cord-335975-m6lkrehi 1961 14 of of IN cord-335975-m6lkrehi 1961 15 intensive intensive JJ cord-335975-m6lkrehi 1961 16 care care NN cord-335975-m6lkrehi 1961 17 . . . cord-335975-m6lkrehi 1962 1 Due due IN cord-335975-m6lkrehi 1962 2 to to IN cord-335975-m6lkrehi 1962 3 the the DT cord-335975-m6lkrehi 1962 4 different different JJ cord-335975-m6lkrehi 1962 5 structure structure NN cord-335975-m6lkrehi 1962 6 of of IN cord-335975-m6lkrehi 1962 7 the the DT cord-335975-m6lkrehi 1962 8 healthcare healthcare NN cord-335975-m6lkrehi 1962 9 system system NN cord-335975-m6lkrehi 1962 10 in in IN cord-335975-m6lkrehi 1962 11 France France NNP cord-335975-m6lkrehi 1962 12 , , , cord-335975-m6lkrehi 1962 13 we -PRON- PRP cord-335975-m6lkrehi 1962 14 aimed aim VBD cord-335975-m6lkrehi 1962 15 to to TO cord-335975-m6lkrehi 1962 16 investigate investigate VB cord-335975-m6lkrehi 1962 17 whether whether IN cord-335975-m6lkrehi 1962 18 socio socio JJ cord-335975-m6lkrehi 1962 19 - - JJ cord-335975-m6lkrehi 1962 20 economic economic JJ cord-335975-m6lkrehi 1962 21 status status NN cord-335975-m6lkrehi 1962 22 influences influence VBZ cord-335975-m6lkrehi 1962 23 initial initial JJ cord-335975-m6lkrehi 1962 24 severity severity NN cord-335975-m6lkrehi 1962 25 of of IN cord-335975-m6lkrehi 1962 26 disease disease NN cord-335975-m6lkrehi 1962 27 and and CC cord-335975-m6lkrehi 1963 1 3 3 CD cord-335975-m6lkrehi 1963 2 months month NNS cord-335975-m6lkrehi 1963 3 mortality mortality NN cord-335975-m6lkrehi 1963 4 in in IN cord-335975-m6lkrehi 1963 5 patients patient NNS cord-335975-m6lkrehi 1963 6 admitted admit VBN cord-335975-m6lkrehi 1963 7 to to IN cord-335975-m6lkrehi 1963 8 intensive intensive JJ cord-335975-m6lkrehi 1963 9 care care NN cord-335975-m6lkrehi 1963 10 in in IN cord-335975-m6lkrehi 1963 11 France France NNP cord-335975-m6lkrehi 1963 12 . . . cord-335975-m6lkrehi 1964 1 Patients patient NNS cord-335975-m6lkrehi 1964 2 and and CC cord-335975-m6lkrehi 1964 3 methods method NNS cord-335975-m6lkrehi 1964 4 : : : cord-335975-m6lkrehi 1964 5 Prospective prospective NN cord-335975-m6lkrehi 1964 6 , , , cord-335975-m6lkrehi 1964 7 multicentre multicentre NNP cord-335975-m6lkrehi 1964 8 , , , cord-335975-m6lkrehi 1964 9 cohort cohort NN cord-335975-m6lkrehi 1964 10 study study NN cord-335975-m6lkrehi 1964 11 including include VBG cord-335975-m6lkrehi 1964 12 1396 1396 CD cord-335975-m6lkrehi 1964 13 adult adult NN cord-335975-m6lkrehi 1964 14 patients patient NNS cord-335975-m6lkrehi 1964 15 admitted admit VBD cord-335975-m6lkrehi 1964 16 to to IN cord-335975-m6lkrehi 1964 17 one one CD cord-335975-m6lkrehi 1964 18 of of IN cord-335975-m6lkrehi 1964 19 8 8 CD cord-335975-m6lkrehi 1964 20 participating participate VBG cord-335975-m6lkrehi 1964 21 intensive intensive JJ cord-335975-m6lkrehi 1964 22 care care NN cord-335975-m6lkrehi 1964 23 units unit NNS cord-335975-m6lkrehi 1964 24 ( ( -LRB- cord-335975-m6lkrehi 1964 25 ICUs ICUs NNP cord-335975-m6lkrehi 1964 26 ) ) -RRB- cord-335975-m6lkrehi 1964 27 between between IN cord-335975-m6lkrehi 1964 28 2012 2012 CD cord-335975-m6lkrehi 1964 29 and and CC cord-335975-m6lkrehi 1964 30 2016 2016 CD cord-335975-m6lkrehi 1964 31 , , , cord-335975-m6lkrehi 1964 32 and and CC cord-335975-m6lkrehi 1964 33 presenting present VBG cord-335975-m6lkrehi 1964 34 failure failure NN cord-335975-m6lkrehi 1964 35 of of IN cord-335975-m6lkrehi 1964 36 one one CD cord-335975-m6lkrehi 1964 37 or or CC cord-335975-m6lkrehi 1964 38 more more JJR cord-335975-m6lkrehi 1964 39 major major JJ cord-335975-m6lkrehi 1964 40 organs organ NNS cord-335975-m6lkrehi 1964 41 . . . cord-335975-m6lkrehi 1965 1 Patients patient NNS cord-335975-m6lkrehi 1965 2 were be VBD cord-335975-m6lkrehi 1965 3 considered consider VBN cord-335975-m6lkrehi 1965 4 to to TO cord-335975-m6lkrehi 1965 5 have have VB cord-335975-m6lkrehi 1965 6 a a DT cord-335975-m6lkrehi 1965 7 precarious precarious JJ cord-335975-m6lkrehi 1965 8 socio socio JJ cord-335975-m6lkrehi 1965 9 - - HYPH cord-335975-m6lkrehi 1965 10 economic economic JJ cord-335975-m6lkrehi 1965 11 status status NN cord-335975-m6lkrehi 1965 12 if if IN cord-335975-m6lkrehi 1965 13 they -PRON- PRP cord-335975-m6lkrehi 1965 14 presented present VBD cord-335975-m6lkrehi 1965 15 at at IN cord-335975-m6lkrehi 1965 16 least least RBS cord-335975-m6lkrehi 1965 17 one one CD cord-335975-m6lkrehi 1965 18 criterion criterion NN cord-335975-m6lkrehi 1965 19 of of IN cord-335975-m6lkrehi 1965 20 social social JJ cord-335975-m6lkrehi 1965 21 vulnerability vulnerability NN cord-335975-m6lkrehi 1965 22 or or CC cord-335975-m6lkrehi 1965 23 a a DT cord-335975-m6lkrehi 1965 24 high high JJ cord-335975-m6lkrehi 1965 25 EPICES epices NN cord-335975-m6lkrehi 1965 26 deprivation deprivation NN cord-335975-m6lkrehi 1965 27 score score NN cord-335975-m6lkrehi 1965 28 . . . cord-335975-m6lkrehi 1966 1 Results result NNS cord-335975-m6lkrehi 1966 2 : : : cord-335975-m6lkrehi 1967 1 Data datum NNS cord-335975-m6lkrehi 1967 2 on on IN cord-335975-m6lkrehi 1967 3 social social JJ cord-335975-m6lkrehi 1967 4 vulnerability vulnerability NN cord-335975-m6lkrehi 1967 5 were be VBD cord-335975-m6lkrehi 1967 6 available available JJ cord-335975-m6lkrehi 1967 7 for for IN cord-335975-m6lkrehi 1967 8 1281 1281 CD cord-335975-m6lkrehi 1967 9 patients patient NNS cord-335975-m6lkrehi 1967 10 , , , cord-335975-m6lkrehi 1967 11 of of IN cord-335975-m6lkrehi 1967 12 whom whom WP cord-335975-m6lkrehi 1967 13 54.3 54.3 CD cord-335975-m6lkrehi 1967 14 % % NN cord-335975-m6lkrehi 1967 15 were be VBD cord-335975-m6lkrehi 1967 16 considered consider VBN cord-335975-m6lkrehi 1967 17 to to TO cord-335975-m6lkrehi 1967 18 be be VB cord-335975-m6lkrehi 1967 19 socially socially RB cord-335975-m6lkrehi 1967 20 vulnerable vulnerable JJ cord-335975-m6lkrehi 1967 21 . . . cord-335975-m6lkrehi 1968 1 Compared compare VBN cord-335975-m6lkrehi 1968 2 to to IN cord-335975-m6lkrehi 1968 3 non non JJ cord-335975-m6lkrehi 1968 4 - - JJ cord-335975-m6lkrehi 1968 5 vulnerable vulnerable JJ cord-335975-m6lkrehi 1968 6 patients patient NNS cord-335975-m6lkrehi 1968 7 , , , cord-335975-m6lkrehi 1968 8 socially socially RB cord-335975-m6lkrehi 1968 9 vulnerable vulnerable JJ cord-335975-m6lkrehi 1968 10 patients patient NNS cord-335975-m6lkrehi 1968 11 were be VBD cord-335975-m6lkrehi 1968 12 younger young JJR cord-335975-m6lkrehi 1968 13 ( ( -LRB- cord-335975-m6lkrehi 1968 14 64.8 64.8 CD cord-335975-m6lkrehi 1968 15 vs vs IN cord-335975-m6lkrehi 1968 16 67.2 67.2 CD cord-335975-m6lkrehi 1968 17 years year NNS cord-335975-m6lkrehi 1968 18 , , , cord-335975-m6lkrehi 1968 19 p p NN cord-335975-m6lkrehi 1968 20 = = SYM cord-335975-m6lkrehi 1968 21 0.006 0.006 CD cord-335975-m6lkrehi 1968 22 ) ) -RRB- cord-335975-m6lkrehi 1968 23 , , , cord-335975-m6lkrehi 1968 24 more more RBR cord-335975-m6lkrehi 1968 25 frequently frequently RB cord-335975-m6lkrehi 1968 26 had have VBD cord-335975-m6lkrehi 1968 27 chronic chronic JJ cord-335975-m6lkrehi 1968 28 disease disease NN cord-335975-m6lkrehi 1968 29 ( ( -LRB- cord-335975-m6lkrehi 1968 30 18.0 18.0 CD cord-335975-m6lkrehi 1968 31 vs vs IN cord-335975-m6lkrehi 1968 32 12.0 12.0 CD cord-335975-m6lkrehi 1968 33 % % NN cord-335975-m6lkrehi 1968 34 , , , cord-335975-m6lkrehi 1968 35 p p NN cord-335975-m6lkrehi 1968 36 = = SYM cord-335975-m6lkrehi 1968 37 0.003 0.003 CD cord-335975-m6lkrehi 1968 38 respectively respectively RB cord-335975-m6lkrehi 1968 39 for for IN cord-335975-m6lkrehi 1968 40 congestive congestive JJ cord-335975-m6lkrehi 1968 41 heart heart NN cord-335975-m6lkrehi 1968 42 failure failure NN cord-335975-m6lkrehi 1968 43 and and CC cord-335975-m6lkrehi 1968 44 26.8%vs 26.8%vs CD cord-335975-m6lkrehi 1968 45 18.1 18.1 CD cord-335975-m6lkrehi 1968 46 % % NN cord-335975-m6lkrehi 1968 47 , , , cord-335975-m6lkrehi 1968 48 p p NN cord-335975-m6lkrehi 1968 49 = = SYM cord-335975-m6lkrehi 1968 50 0.0002 0.0002 CD cord-335975-m6lkrehi 1968 51 for for IN cord-335975-m6lkrehi 1968 52 chronic chronic JJ cord-335975-m6lkrehi 1968 53 respiratory respiratory JJ cord-335975-m6lkrehi 1968 54 disease disease NN cord-335975-m6lkrehi 1968 55 ) ) -RRB- cord-335975-m6lkrehi 1968 56 , , , cord-335975-m6lkrehi 1968 57 had have VBD cord-335975-m6lkrehi 1968 58 higher high JJR cord-335975-m6lkrehi 1968 59 levels level NNS cord-335975-m6lkrehi 1968 60 of of IN cord-335975-m6lkrehi 1968 61 physical physical JJ cord-335975-m6lkrehi 1968 62 dependency dependency NN cord-335975-m6lkrehi 1968 63 ( ( -LRB- cord-335975-m6lkrehi 1968 64 9.2 9.2 CD cord-335975-m6lkrehi 1968 65 vs vs IN cord-335975-m6lkrehi 1968 66 4.7 4.7 CD cord-335975-m6lkrehi 1968 67 % % NN cord-335975-m6lkrehi 1968 68 , , , cord-335975-m6lkrehi 1968 69 p p NN cord-335975-m6lkrehi 1968 70 = = SYM cord-335975-m6lkrehi 1968 71 0.002 0.002 CD cord-335975-m6lkrehi 1968 72 ) ) -RRB- cord-335975-m6lkrehi 1968 73 , , , cord-335975-m6lkrehi 1968 74 and and CC cord-335975-m6lkrehi 1968 75 were be VBD cord-335975-m6lkrehi 1968 76 more more RBR cord-335975-m6lkrehi 1968 77 often often RB cord-335975-m6lkrehi 1968 78 classed class VBN cord-335975-m6lkrehi 1968 79 as as IN cord-335975-m6lkrehi 1968 80 having have VBG cord-335975-m6lkrehi 1968 81 long long JJ cord-335975-m6lkrehi 1968 82 - - HYPH cord-335975-m6lkrehi 1968 83 term term NN cord-335975-m6lkrehi 1968 84 health health NN cord-335975-m6lkrehi 1968 85 conditions condition NNS cord-335975-m6lkrehi 1968 86 ( ( -LRB- cord-335975-m6lkrehi 1968 87 67.1 67.1 CD cord-335975-m6lkrehi 1968 88 vs vs IN cord-335975-m6lkrehi 1968 89 62.1 62.1 CD cord-335975-m6lkrehi 1968 90 % % NN cord-335975-m6lkrehi 1968 91 , , , cord-335975-m6lkrehi 1968 92 p p NN cord-335975-m6lkrehi 1968 93 < < XX cord-335975-m6lkrehi 1968 94 0.0001 0.0001 CD cord-335975-m6lkrehi 1968 95 ) ) -RRB- cord-335975-m6lkrehi 1968 96 . . . cord-335975-m6lkrehi 1969 1 Conversely conversely RB cord-335975-m6lkrehi 1969 2 , , , cord-335975-m6lkrehi 1969 3 non non JJ cord-335975-m6lkrehi 1969 4 - - JJ cord-335975-m6lkrehi 1969 5 vulnerable vulnerable JJ cord-335975-m6lkrehi 1969 6 patients patient NNS cord-335975-m6lkrehi 1969 7 had have VBD cord-335975-m6lkrehi 1969 8 greater great JJR cord-335975-m6lkrehi 1969 9 severity severity NN cord-335975-m6lkrehi 1969 10 of of IN cord-335975-m6lkrehi 1969 11 disease disease NN cord-335975-m6lkrehi 1969 12 at at IN cord-335975-m6lkrehi 1969 13 admission admission NN cord-335975-m6lkrehi 1969 14 to to IN cord-335975-m6lkrehi 1969 15 the the DT cord-335975-m6lkrehi 1969 16 ICU ICU NNP cord-335975-m6lkrehi 1969 17 than than IN cord-335975-m6lkrehi 1969 18 those those DT cord-335975-m6lkrehi 1969 19 classed class VBN cord-335975-m6lkrehi 1969 20 as as IN cord-335975-m6lkrehi 1969 21 vulnerable vulnerable JJ cord-335975-m6lkrehi 1969 22 , , , cord-335975-m6lkrehi 1969 23 both both CC cord-335975-m6lkrehi 1969 24 in in IN cord-335975-m6lkrehi 1969 25 terms term NNS cord-335975-m6lkrehi 1969 26 of of IN cord-335975-m6lkrehi 1969 27 SAPS SAPS NNP cord-335975-m6lkrehi 1969 28 II II NNP cord-335975-m6lkrehi 1969 29 and and CC cord-335975-m6lkrehi 1969 30 SOFA sofa NN cord-335975-m6lkrehi 1969 31 scores score NNS cord-335975-m6lkrehi 1969 32 ( ( -LRB- cord-335975-m6lkrehi 1969 33 respectively respectively RB cord-335975-m6lkrehi 1969 34 53.16 53.16 CD cord-335975-m6lkrehi 1969 35 vs vs IN cord-335975-m6lkrehi 1969 36 50.09 50.09 CD cord-335975-m6lkrehi 1969 37 ( ( -LRB- cord-335975-m6lkrehi 1969 38 p p NN cord-335975-m6lkrehi 1969 39 = = SYM cord-335975-m6lkrehi 1969 40 0.001 0.001 CD cord-335975-m6lkrehi 1969 41 ) ) -RRB- cord-335975-m6lkrehi 1969 42 and and CC cord-335975-m6lkrehi 1969 43 8.35 8.35 CD cord-335975-m6lkrehi 1969 44 vs vs IN cord-335975-m6lkrehi 1969 45 7.77(p 7.77(p CD cord-335975-m6lkrehi 1969 46 = = SYM cord-335975-m6lkrehi 1969 47 0.002 0.002 CD cord-335975-m6lkrehi 1969 48 ) ) -RRB- cord-335975-m6lkrehi 1969 49 ) ) -RRB- cord-335975-m6lkrehi 1969 50 . . . cord-335975-m6lkrehi 1970 1 Findings finding NNS cord-335975-m6lkrehi 1970 2 were be VBD cord-335975-m6lkrehi 1970 3 similar similar JJ cord-335975-m6lkrehi 1970 4 after after IN cord-335975-m6lkrehi 1970 5 adjusting adjust VBG cord-335975-m6lkrehi 1970 6 for for IN cord-335975-m6lkrehi 1970 7 major major JJ cord-335975-m6lkrehi 1970 8 confounders confounder NNS cord-335975-m6lkrehi 1970 9 ( ( -LRB- cord-335975-m6lkrehi 1970 10 adjusted adjust VBN cord-335975-m6lkrehi 1970 11 odds odd NNS cord-335975-m6lkrehi 1970 12 ratio ratio NN cord-335975-m6lkrehi 1970 13 ( ( -LRB- cord-335975-m6lkrehi 1970 14 OR or NN cord-335975-m6lkrehi 1970 15 ) ) -RRB- cord-335975-m6lkrehi 1971 1 0.62 0.62 CD cord-335975-m6lkrehi 1971 2 , , , cord-335975-m6lkrehi 1971 3 95 95 CD cord-335975-m6lkrehi 1971 4 % % NN cord-335975-m6lkrehi 1971 5 confidence confidence NN cord-335975-m6lkrehi 1971 6 interval interval NN cord-335975-m6lkrehi 1971 7 ( ( -LRB- cord-335975-m6lkrehi 1971 8 CI CI NNP cord-335975-m6lkrehi 1971 9 ) ) -RRB- cord-335975-m6lkrehi 1971 10 [ [ -LRB- cord-335975-m6lkrehi 1971 11 0.48 0.48 CD cord-335975-m6lkrehi 1971 12 - - HYPH cord-335975-m6lkrehi 1971 13 0.81 0.81 CD cord-335975-m6lkrehi 1971 14 ] ] -RRB- cord-335975-m6lkrehi 1971 15 , , , cord-335975-m6lkrehi 1971 16 p p NN cord-335975-m6lkrehi 1971 17 = = SYM cord-335975-m6lkrehi 1971 18 0.0005 0.0005 CD cord-335975-m6lkrehi 1971 19 ) ) -RRB- cord-335975-m6lkrehi 1971 20 . . . cord-335975-m6lkrehi 1972 1 Mortality mortality NN cord-335975-m6lkrehi 1972 2 at at IN cord-335975-m6lkrehi 1972 3 3 3 CD cord-335975-m6lkrehi 1972 4 months month NNS cord-335975-m6lkrehi 1972 5 was be VBD cord-335975-m6lkrehi 1972 6 not not RB cord-335975-m6lkrehi 1972 7 significantly significantly RB cord-335975-m6lkrehi 1972 8 different different JJ cord-335975-m6lkrehi 1972 9 between between IN cord-335975-m6lkrehi 1972 10 socially socially RB cord-335975-m6lkrehi 1972 11 vulnerable vulnerable JJ cord-335975-m6lkrehi 1972 12 patients patient NNS cord-335975-m6lkrehi 1972 13 and and CC cord-335975-m6lkrehi 1972 14 those those DT cord-335975-m6lkrehi 1972 15 not not RB cord-335975-m6lkrehi 1972 16 considered consider VBN cord-335975-m6lkrehi 1972 17 vulnerable vulnerable JJ cord-335975-m6lkrehi 1972 18 , , , cord-335975-m6lkrehi 1972 19 respectively respectively RB cord-335975-m6lkrehi 1972 20 34.6 34.6 CD cord-335975-m6lkrehi 1972 21 vs vs IN cord-335975-m6lkrehi 1972 22 36.10 36.10 CD cord-335975-m6lkrehi 1972 23 % % NN cord-335975-m6lkrehi 1972 24 ( ( -LRB- cord-335975-m6lkrehi 1972 25 p p NN cord-335975-m6lkrehi 1972 26 = = SYM cord-335975-m6lkrehi 1972 27 0.62 0.62 CD cord-335975-m6lkrehi 1972 28 ) ) -RRB- cord-335975-m6lkrehi 1972 29 , , , cord-335975-m6lkrehi 1972 30 even even RB cord-335975-m6lkrehi 1972 31 after after IN cord-335975-m6lkrehi 1972 32 adjustment adjustment NN cord-335975-m6lkrehi 1972 33 for for IN cord-335975-m6lkrehi 1972 34 initial initial JJ cord-335975-m6lkrehi 1972 35 severity severity NN cord-335975-m6lkrehi 1972 36 . . . cord-335975-m6lkrehi 1973 1 Conclusion conclusion NN cord-335975-m6lkrehi 1973 2 : : : cord-335975-m6lkrehi 1974 1 Despite despite IN cord-335975-m6lkrehi 1974 2 less less RBR cord-335975-m6lkrehi 1974 3 severe severe JJ cord-335975-m6lkrehi 1974 4 disease disease NN cord-335975-m6lkrehi 1974 5 at at IN cord-335975-m6lkrehi 1974 6 admission admission NN cord-335975-m6lkrehi 1974 7 to to IN cord-335975-m6lkrehi 1974 8 the the DT cord-335975-m6lkrehi 1974 9 ICU ICU NNP cord-335975-m6lkrehi 1974 10 among among IN cord-335975-m6lkrehi 1974 11 patients patient NNS cord-335975-m6lkrehi 1974 12 considered consider VBN cord-335975-m6lkrehi 1974 13 socially socially RB cord-335975-m6lkrehi 1974 14 vulnerable vulnerable JJ cord-335975-m6lkrehi 1974 15 , , , cord-335975-m6lkrehi 1974 16 3-month 3-month CD cord-335975-m6lkrehi 1974 17 mortality mortality NN cord-335975-m6lkrehi 1974 18 did do VBD cord-335975-m6lkrehi 1974 19 not not RB cord-335975-m6lkrehi 1974 20 differ differ VB cord-335975-m6lkrehi 1974 21 significantly significantly RB cord-335975-m6lkrehi 1974 22 between between IN cord-335975-m6lkrehi 1974 23 those those DT cord-335975-m6lkrehi 1974 24 who who WP cord-335975-m6lkrehi 1974 25 were be VBD cord-335975-m6lkrehi 1974 26 socially socially RB cord-335975-m6lkrehi 1974 27 vulnerable vulnerable JJ cord-335975-m6lkrehi 1974 28 and and CC cord-335975-m6lkrehi 1974 29 those those DT cord-335975-m6lkrehi 1974 30 who who WP cord-335975-m6lkrehi 1974 31 were be VBD cord-335975-m6lkrehi 1974 32 not not RB cord-335975-m6lkrehi 1974 33 . . . cord-335975-m6lkrehi 1975 1 These these DT cord-335975-m6lkrehi 1975 2 findings finding NNS cord-335975-m6lkrehi 1975 3 suggest suggest VBP cord-335975-m6lkrehi 1975 4 that that IN cord-335975-m6lkrehi 1975 5 the the DT cord-335975-m6lkrehi 1975 6 French french JJ cord-335975-m6lkrehi 1975 7 healthcare healthcare NN cord-335975-m6lkrehi 1975 8 system system NN cord-335975-m6lkrehi 1975 9 provides provide VBZ cord-335975-m6lkrehi 1975 10 good good JJ cord-335975-m6lkrehi 1975 11 protection protection NN cord-335975-m6lkrehi 1975 12 for for IN cord-335975-m6lkrehi 1975 13 the the DT cord-335975-m6lkrehi 1975 14 most most RBS cord-335975-m6lkrehi 1975 15 disadvantaged disadvantaged JJ cord-335975-m6lkrehi 1975 16 members member NNS cord-335975-m6lkrehi 1975 17 of of IN cord-335975-m6lkrehi 1975 18 society society NN cord-335975-m6lkrehi 1975 19 , , , cord-335975-m6lkrehi 1975 20 particularly particularly RB cord-335975-m6lkrehi 1975 21 when when WRB cord-335975-m6lkrehi 1975 22 they -PRON- PRP cord-335975-m6lkrehi 1975 23 are be VBP cord-335975-m6lkrehi 1975 24 admitted admit VBN cord-335975-m6lkrehi 1975 25 to to IN cord-335975-m6lkrehi 1975 26 the the DT cord-335975-m6lkrehi 1975 27 ICU ICU NNP cord-335975-m6lkrehi 1975 28 . . . cord-335975-m6lkrehi 1976 1 Introduction introduction NN cord-335975-m6lkrehi 1976 2 : : : cord-335975-m6lkrehi 1977 1 An an DT cord-335975-m6lkrehi 1977 2 approach approach NN cord-335975-m6lkrehi 1977 3 of of IN cord-335975-m6lkrehi 1977 4 the the DT cord-335975-m6lkrehi 1977 5 quality quality NN cord-335975-m6lkrehi 1977 6 of of IN cord-335975-m6lkrehi 1977 7 care care NN cord-335975-m6lkrehi 1977 8 may may MD cord-335975-m6lkrehi 1977 9 involve involve VB cord-335975-m6lkrehi 1977 10 assessing assess VBG cord-335975-m6lkrehi 1977 11 the the DT cord-335975-m6lkrehi 1977 12 patients patient NNS cord-335975-m6lkrehi 1977 13 ' ' POS cord-335975-m6lkrehi 1977 14 satisfaction satisfaction NN cord-335975-m6lkrehi 1977 15 . . . cord-335975-m6lkrehi 1978 1 However however RB cord-335975-m6lkrehi 1978 2 , , , cord-335975-m6lkrehi 1978 3 the the DT cord-335975-m6lkrehi 1978 4 extended extended JJ cord-335975-m6lkrehi 1978 5 caregiverpatient caregiverpatient NN cord-335975-m6lkrehi 1978 6 and and CC cord-335975-m6lkrehi 1978 7 family family NN cord-335975-m6lkrehi 1978 8 relationship relationship NN cord-335975-m6lkrehi 1978 9 , , , cord-335975-m6lkrehi 1978 10 specific specific JJ cord-335975-m6lkrehi 1978 11 to to IN cord-335975-m6lkrehi 1978 12 the the DT cord-335975-m6lkrehi 1978 13 critically critically RB cord-335975-m6lkrehi 1978 14 ill ill JJ cord-335975-m6lkrehi 1978 15 patients patient NNS cord-335975-m6lkrehi 1978 16 , , , cord-335975-m6lkrehi 1978 17 may may MD cord-335975-m6lkrehi 1978 18 also also RB cord-335975-m6lkrehi 1978 19 require require VB cord-335975-m6lkrehi 1978 20 to to TO cord-335975-m6lkrehi 1978 21 assess assess VB cord-335975-m6lkrehi 1978 22 the the DT cord-335975-m6lkrehi 1978 23 proxies proxy NNS cord-335975-m6lkrehi 1978 24 ' ' POS cord-335975-m6lkrehi 1978 25 satisfaction satisfaction NN cord-335975-m6lkrehi 1978 26 . . . cord-335975-m6lkrehi 1979 1 The the DT cord-335975-m6lkrehi 1979 2 OpinionFamily OpinionFamily NNP cord-335975-m6lkrehi 1979 3 tool tool NN cord-335975-m6lkrehi 1979 4 was be VBD cord-335975-m6lkrehi 1979 5 developed develop VBN cord-335975-m6lkrehi 1979 6 to to TO cord-335975-m6lkrehi 1979 7 assess assess VB cord-335975-m6lkrehi 1979 8 the the DT cord-335975-m6lkrehi 1979 9 satisfaction satisfaction NN cord-335975-m6lkrehi 1979 10 of of IN cord-335975-m6lkrehi 1979 11 the the DT cord-335975-m6lkrehi 1979 12 critically critically RB cord-335975-m6lkrehi 1979 13 ill ill JJ cord-335975-m6lkrehi 1979 14 patients patient NNS cord-335975-m6lkrehi 1979 15 ' ' POS cord-335975-m6lkrehi 1979 16 proxies proxy NNS cord-335975-m6lkrehi 1979 17 , , , cord-335975-m6lkrehi 1979 18 in in IN cord-335975-m6lkrehi 1979 19 an an DT cord-335975-m6lkrehi 1979 20 anonymous anonymous JJ cord-335975-m6lkrehi 1979 21 and and CC cord-335975-m6lkrehi 1979 22 continuous continuous JJ cord-335975-m6lkrehi 1979 23 fashion fashion NN cord-335975-m6lkrehi 1979 24 . . . cord-335975-m6lkrehi 1980 1 We -PRON- PRP cord-335975-m6lkrehi 1980 2 conducted conduct VBD cord-335975-m6lkrehi 1980 3 a a DT cord-335975-m6lkrehi 1980 4 study study NN cord-335975-m6lkrehi 1980 5 in in IN cord-335975-m6lkrehi 1980 6 the the DT cord-335975-m6lkrehi 1980 7 ICU ICU NNP cord-335975-m6lkrehi 1980 8 of of IN cord-335975-m6lkrehi 1980 9 Tenon Tenon NNP cord-335975-m6lkrehi 1980 10 hospital hospital NN cord-335975-m6lkrehi 1980 11 ( ( -LRB- cord-335975-m6lkrehi 1980 12 Paris Paris NNP cord-335975-m6lkrehi 1980 13 , , , cord-335975-m6lkrehi 1980 14 France France NNP cord-335975-m6lkrehi 1980 15 ) ) -RRB- cord-335975-m6lkrehi 1980 16 between between IN cord-335975-m6lkrehi 1980 17 Mars Mars NNP cord-335975-m6lkrehi 1980 18 and and CC cord-335975-m6lkrehi 1980 19 August August NNP cord-335975-m6lkrehi 1980 20 2017 2017 CD cord-335975-m6lkrehi 1980 21 . . . cord-335975-m6lkrehi 1981 1 The the DT cord-335975-m6lkrehi 1981 2 Opinion Opinion NNP cord-335975-m6lkrehi 1981 3 - - HYPH cord-335975-m6lkrehi 1981 4 Family Family NNP cord-335975-m6lkrehi 1981 5 questionnaire questionnaire NN cord-335975-m6lkrehi 1981 6 , , , cord-335975-m6lkrehi 1981 7 built build VBN cord-335975-m6lkrehi 1981 8 with with IN cord-335975-m6lkrehi 1981 9 6 6 CD cord-335975-m6lkrehi 1981 10 categories category NNS cord-335975-m6lkrehi 1981 11 ( ( -LRB- cord-335975-m6lkrehi 1981 12 4 4 CD cord-335975-m6lkrehi 1981 13 items item NNS cord-335975-m6lkrehi 1981 14 each each DT cord-335975-m6lkrehi 1981 15 ) ) -RRB- cord-335975-m6lkrehi 1981 16 , , , cord-335975-m6lkrehi 1981 17 aimed aim VBN cord-335975-m6lkrehi 1981 18 to to TO cord-335975-m6lkrehi 1981 19 measure measure VB cord-335975-m6lkrehi 1981 20 the the DT cord-335975-m6lkrehi 1981 21 proxies proxy NNS cord-335975-m6lkrehi 1981 22 ' ' POS cord-335975-m6lkrehi 1981 23 satisfaction satisfaction NN cord-335975-m6lkrehi 1981 24 regarding regard VBG cord-335975-m6lkrehi 1981 25 their -PRON- PRP$ cord-335975-m6lkrehi 1981 26 perception perception NN cord-335975-m6lkrehi 1981 27 of of IN cord-335975-m6lkrehi 1981 28 the the DT cord-335975-m6lkrehi 1981 29 quality quality NN cord-335975-m6lkrehi 1981 30 of of IN cord-335975-m6lkrehi 1981 31 care care NN cord-335975-m6lkrehi 1981 32 . . . cord-335975-m6lkrehi 1982 1 All all PDT cord-335975-m6lkrehi 1982 2 the the DT cord-335975-m6lkrehi 1982 3 proxies proxy NNS cord-335975-m6lkrehi 1982 4 were be VBD cord-335975-m6lkrehi 1982 5 invited invite VBN cord-335975-m6lkrehi 1982 6 to to TO cord-335975-m6lkrehi 1982 7 express express VB cord-335975-m6lkrehi 1982 8 voluntarily voluntarily RB cord-335975-m6lkrehi 1982 9 and and CC cord-335975-m6lkrehi 1982 10 anonymously anonymously RB cord-335975-m6lkrehi 1982 11 his -PRON- PRP$ cord-335975-m6lkrehi 1982 12 her -PRON- PRP$ cord-335975-m6lkrehi 1982 13 degree degree NN cord-335975-m6lkrehi 1982 14 of of IN cord-335975-m6lkrehi 1982 15 agreement agreement NN cord-335975-m6lkrehi 1982 16 as as IN cord-335975-m6lkrehi 1982 17 a a DT cord-335975-m6lkrehi 1982 18 response response NN cord-335975-m6lkrehi 1982 19 to to IN cord-335975-m6lkrehi 1982 20 a a DT cord-335975-m6lkrehi 1982 21 statement statement NN cord-335975-m6lkrehi 1982 22 by by IN cord-335975-m6lkrehi 1982 23 the the DT cord-335975-m6lkrehi 1982 24 selection selection NN cord-335975-m6lkrehi 1982 25 of of IN cord-335975-m6lkrehi 1982 26 the the DT cord-335975-m6lkrehi 1982 27 corresponding correspond VBG cord-335975-m6lkrehi 1982 28 stars star NNS cord-335975-m6lkrehi 1982 29 ( ( -LRB- cord-335975-m6lkrehi 1982 30 strongly strongly RB cord-335975-m6lkrehi 1982 31 disagree-1 disagree-1 NNP cord-335975-m6lkrehi 1982 32 star star NN cord-335975-m6lkrehi 1982 33 , , , cord-335975-m6lkrehi 1982 34 disagree-2 disagree-2 NNP cord-335975-m6lkrehi 1982 35 stars star NNS cord-335975-m6lkrehi 1982 36 , , , cord-335975-m6lkrehi 1982 37 neither neither CC cord-335975-m6lkrehi 1982 38 agree agree VBP cord-335975-m6lkrehi 1982 39 nor nor CC cord-335975-m6lkrehi 1982 40 disagree-3 disagree-3 NNP cord-335975-m6lkrehi 1982 41 stars star NNS cord-335975-m6lkrehi 1982 42 , , , cord-335975-m6lkrehi 1982 43 agree-4 agree-4 NNP cord-335975-m6lkrehi 1982 44 stars star NNS cord-335975-m6lkrehi 1982 45 , , , cord-335975-m6lkrehi 1982 46 strongly strongly RB cord-335975-m6lkrehi 1982 47 agree-5 agree-5 NNP cord-335975-m6lkrehi 1982 48 stars star NNS cord-335975-m6lkrehi 1982 49 ) ) -RRB- cord-335975-m6lkrehi 1982 50 using use VBG cord-335975-m6lkrehi 1982 51 a a DT cord-335975-m6lkrehi 1982 52 secure secure JJ cord-335975-m6lkrehi 1982 53 touch touch NN cord-335975-m6lkrehi 1982 54 screen screen NN cord-335975-m6lkrehi 1982 55 disposed dispose VBD cord-335975-m6lkrehi 1982 56 24 24 CD cord-335975-m6lkrehi 1982 57 7 7 CD cord-335975-m6lkrehi 1982 58 in in IN cord-335975-m6lkrehi 1982 59 the the DT cord-335975-m6lkrehi 1982 60 waiting waiting NN cord-335975-m6lkrehi 1982 61 room room NN cord-335975-m6lkrehi 1982 62 of of IN cord-335975-m6lkrehi 1982 63 the the DT cord-335975-m6lkrehi 1982 64 ICU ICU NNP cord-335975-m6lkrehi 1982 65 . . . cord-335975-m6lkrehi 1983 1 Results result NNS cord-335975-m6lkrehi 1983 2 : : : cord-335975-m6lkrehi 1984 1 Altogether altogether RB cord-335975-m6lkrehi 1984 2 , , , cord-335975-m6lkrehi 1984 3 456 456 CD cord-335975-m6lkrehi 1984 4 patients patient NNS cord-335975-m6lkrehi 1984 5 were be VBD cord-335975-m6lkrehi 1984 6 hospitalised hospitalise VBN cord-335975-m6lkrehi 1984 7 during during IN cord-335975-m6lkrehi 1984 8 the the DT cord-335975-m6lkrehi 1984 9 study study NN cord-335975-m6lkrehi 1984 10 period period NN cord-335975-m6lkrehi 1984 11 , , , cord-335975-m6lkrehi 1984 12 and and CC cord-335975-m6lkrehi 1984 13 148 148 CD cord-335975-m6lkrehi 1984 14 proxies proxy NNS cord-335975-m6lkrehi 1984 15 completed complete VBD cord-335975-m6lkrehi 1984 16 the the DT cord-335975-m6lkrehi 1984 17 questionnaire questionnaire NN cord-335975-m6lkrehi 1984 18 . . . cord-335975-m6lkrehi 1985 1 All all PDT cord-335975-m6lkrehi 1985 2 the the DT cord-335975-m6lkrehi 1985 3 responders responder NNS cord-335975-m6lkrehi 1985 4 spoke speak VBD cord-335975-m6lkrehi 1985 5 French French NNP cord-335975-m6lkrehi 1985 6 . . . cord-335975-m6lkrehi 1986 1 Only only RB cord-335975-m6lkrehi 1986 2 12 12 CD cord-335975-m6lkrehi 1986 3 responders responder NNS cord-335975-m6lkrehi 1986 4 ( ( -LRB- cord-335975-m6lkrehi 1986 5 9 9 CD cord-335975-m6lkrehi 1986 6 % % NN cord-335975-m6lkrehi 1986 7 ) ) -RRB- cord-335975-m6lkrehi 1986 8 answered answer VBD cord-335975-m6lkrehi 1986 9 more more JJR cord-335975-m6lkrehi 1986 10 than than IN cord-335975-m6lkrehi 1986 11 one one CD cord-335975-m6lkrehi 1986 12 time time NN cord-335975-m6lkrehi 1986 13 . . . cord-335975-m6lkrehi 1987 1 Of of IN cord-335975-m6lkrehi 1987 2 the the DT cord-335975-m6lkrehi 1987 3 responders responder NNS cord-335975-m6lkrehi 1987 4 , , , cord-335975-m6lkrehi 1987 5 105 105 CD cord-335975-m6lkrehi 1987 6 ( ( -LRB- cord-335975-m6lkrehi 1987 7 71 71 CD cord-335975-m6lkrehi 1987 8 % % NN cord-335975-m6lkrehi 1987 9 ) ) -RRB- cord-335975-m6lkrehi 1987 10 were be VBD cord-335975-m6lkrehi 1987 11 the the DT cord-335975-m6lkrehi 1987 12 referring refer VBG cord-335975-m6lkrehi 1987 13 person person NN cord-335975-m6lkrehi 1987 14 , , , cord-335975-m6lkrehi 1987 15 47 47 CD cord-335975-m6lkrehi 1987 16 ( ( -LRB- cord-335975-m6lkrehi 1987 17 32 32 CD cord-335975-m6lkrehi 1987 18 % % NN cord-335975-m6lkrehi 1987 19 ) ) -RRB- cord-335975-m6lkrehi 1987 20 were be VBD cord-335975-m6lkrehi 1987 21 children child NNS cord-335975-m6lkrehi 1987 22 and and CC cord-335975-m6lkrehi 1987 23 26 26 CD cord-335975-m6lkrehi 1987 24 ( ( -LRB- cord-335975-m6lkrehi 1987 25 17 17 CD cord-335975-m6lkrehi 1987 26 % % NN cord-335975-m6lkrehi 1987 27 ) ) -RRB- cord-335975-m6lkrehi 1987 28 were be VBD cord-335975-m6lkrehi 1987 29 spouses spouse NNS cord-335975-m6lkrehi 1987 30 . . . cord-335975-m6lkrehi 1988 1 During during IN cord-335975-m6lkrehi 1988 2 the the DT cord-335975-m6lkrehi 1988 3 study study NN cord-335975-m6lkrehi 1988 4 period period NN cord-335975-m6lkrehi 1988 5 , , , cord-335975-m6lkrehi 1988 6 50 50 CD cord-335975-m6lkrehi 1988 7 ( ( -LRB- cord-335975-m6lkrehi 1988 8 34 34 CD cord-335975-m6lkrehi 1988 9 % % NN cord-335975-m6lkrehi 1988 10 ) ) -RRB- cord-335975-m6lkrehi 1988 11 , , , cord-335975-m6lkrehi 1988 12 59 59 CD cord-335975-m6lkrehi 1988 13 ( ( -LRB- cord-335975-m6lkrehi 1988 14 40 40 CD cord-335975-m6lkrehi 1988 15 % % NN cord-335975-m6lkrehi 1988 16 ) ) -RRB- cord-335975-m6lkrehi 1988 17 , , , cord-335975-m6lkrehi 1988 18 and and CC cord-335975-m6lkrehi 1988 19 38 38 CD cord-335975-m6lkrehi 1988 20 ( ( -LRB- cord-335975-m6lkrehi 1988 21 26 26 CD cord-335975-m6lkrehi 1988 22 % % NN cord-335975-m6lkrehi 1988 23 ) ) -RRB- cord-335975-m6lkrehi 1989 1 responders responder NNS cord-335975-m6lkrehi 1989 2 had have VBD cord-335975-m6lkrehi 1989 3 visited visit VBN cord-335975-m6lkrehi 1989 4 their -PRON- PRP$ cord-335975-m6lkrehi 1989 5 relative relative JJ cord-335975-m6lkrehi 1989 6 1 1 CD cord-335975-m6lkrehi 1989 7 to to IN cord-335975-m6lkrehi 1989 8 3 3 CD cord-335975-m6lkrehi 1989 9 times time NNS cord-335975-m6lkrehi 1989 10 , , , cord-335975-m6lkrehi 1989 11 4 4 CD cord-335975-m6lkrehi 1989 12 to to TO cord-335975-m6lkrehi 1989 13 10 10 CD cord-335975-m6lkrehi 1989 14 times time NNS cord-335975-m6lkrehi 1989 15 , , , cord-335975-m6lkrehi 1989 16 and and CC cord-335975-m6lkrehi 1989 17 more more JJR cord-335975-m6lkrehi 1989 18 than than IN cord-335975-m6lkrehi 1989 19 10 10 CD cord-335975-m6lkrehi 1989 20 times time NNS cord-335975-m6lkrehi 1989 21 , , , cord-335975-m6lkrehi 1989 22 respectively respectively RB cord-335975-m6lkrehi 1989 23 . . . cord-335975-m6lkrehi 1990 1 The the DT cord-335975-m6lkrehi 1990 2 different different JJ cord-335975-m6lkrehi 1990 3 categories category NNS cord-335975-m6lkrehi 1990 4 assessed assess VBN cord-335975-m6lkrehi 1990 5 by by IN cord-335975-m6lkrehi 1990 6 the the DT cord-335975-m6lkrehi 1990 7 OpinionFamily OpinionFamily NNP cord-335975-m6lkrehi 1990 8 tool tool NN cord-335975-m6lkrehi 1990 9 were be VBD cord-335975-m6lkrehi 1990 10 related relate VBN cord-335975-m6lkrehi 1990 11 to to IN cord-335975-m6lkrehi 1990 12 « « '' cord-335975-m6lkrehi 1990 13 the the DT cord-335975-m6lkrehi 1990 14 family family NN cord-335975-m6lkrehi 1990 15 and and CC cord-335975-m6lkrehi 1990 16 the the DT cord-335975-m6lkrehi 1990 17 patient patient NN cord-335975-m6lkrehi 1990 18 » » NN cord-335975-m6lkrehi 1990 19 ( ( -LRB- cord-335975-m6lkrehi 1990 20 Fig Fig NNP cord-335975-m6lkrehi 1990 21 . . . cord-335975-m6lkrehi 1990 22 1A 1a NN cord-335975-m6lkrehi 1990 23 ) ) -RRB- cord-335975-m6lkrehi 1990 24 , , , cord-335975-m6lkrehi 1990 25 « « '' cord-335975-m6lkrehi 1990 26 the the DT cord-335975-m6lkrehi 1990 27 family family NN cord-335975-m6lkrehi 1990 28 and and CC cord-335975-m6lkrehi 1990 29 the the DT cord-335975-m6lkrehi 1990 30 environment environment NN cord-335975-m6lkrehi 1991 1 » » '' cord-335975-m6lkrehi 1992 1 ( ( -LRB- cord-335975-m6lkrehi 1992 2 Fig Fig NNP cord-335975-m6lkrehi 1992 3 . . . cord-335975-m6lkrehi 1992 4 1B 1B NNP cord-335975-m6lkrehi 1992 5 ) ) -RRB- cord-335975-m6lkrehi 1992 6 , , , cord-335975-m6lkrehi 1992 7 and and CC cord-335975-m6lkrehi 1992 8 « « '' cord-335975-m6lkrehi 1993 1 the the DT cord-335975-m6lkrehi 1993 2 family family NN cord-335975-m6lkrehi 1993 3 and and CC cord-335975-m6lkrehi 1993 4 the the DT cord-335975-m6lkrehi 1993 5 caregivers caregiver NNS cord-335975-m6lkrehi 1993 6 - - HYPH cord-335975-m6lkrehi 1993 7 availability availability NN cord-335975-m6lkrehi 1993 8 , , , cord-335975-m6lkrehi 1993 9 trust trust NN cord-335975-m6lkrehi 1993 10 , , , cord-335975-m6lkrehi 1993 11 support support NN cord-335975-m6lkrehi 1993 12 , , , cord-335975-m6lkrehi 1993 13 and and CC cord-335975-m6lkrehi 1993 14 information information NN cord-335975-m6lkrehi 1993 15 » » . cord-335975-m6lkrehi 1994 1 ( ( -LRB- cord-335975-m6lkrehi 1994 2 Fig Fig NNP cord-335975-m6lkrehi 1994 3 . . . cord-335975-m6lkrehi 1994 4 1C 1C NNP cord-335975-m6lkrehi 1994 5 ) ) -RRB- cord-335975-m6lkrehi 1994 6 . . . cord-335975-m6lkrehi 1995 1 The the DT cord-335975-m6lkrehi 1995 2 corresponding correspond VBG cord-335975-m6lkrehi 1995 3 levels level NNS cord-335975-m6lkrehi 1995 4 of of IN cord-335975-m6lkrehi 1995 5 satisfaction satisfaction NN cord-335975-m6lkrehi 1995 6 ( ( -LRB- cord-335975-m6lkrehi 1995 7 responses response NNS cord-335975-m6lkrehi 1995 8 of of IN cord-335975-m6lkrehi 1995 9 at at RB cord-335975-m6lkrehi 1995 10 least least JJS cord-335975-m6lkrehi 1995 11 4 4 CD cord-335975-m6lkrehi 1995 12 stars star NNS cord-335975-m6lkrehi 1995 13 ) ) -RRB- cord-335975-m6lkrehi 1995 14 were be VBD cord-335975-m6lkrehi 1995 15 respectively respectively RB cord-335975-m6lkrehi 1995 16 67 67 CD cord-335975-m6lkrehi 1995 17 , , , cord-335975-m6lkrehi 1995 18 78 78 CD cord-335975-m6lkrehi 1995 19 , , , cord-335975-m6lkrehi 1995 20 65 65 CD cord-335975-m6lkrehi 1995 21 , , , cord-335975-m6lkrehi 1995 22 77 77 CD cord-335975-m6lkrehi 1995 23 , , , cord-335975-m6lkrehi 1995 24 78 78 CD cord-335975-m6lkrehi 1995 25 , , , cord-335975-m6lkrehi 1995 26 and and CC cord-335975-m6lkrehi 1995 27 79 79 CD cord-335975-m6lkrehi 1995 28 % % NN cord-335975-m6lkrehi 1995 29 . . . cord-335975-m6lkrehi 1996 1 Some some DT cord-335975-m6lkrehi 1996 2 items item NNS cord-335975-m6lkrehi 1996 3 were be VBD cord-335975-m6lkrehi 1996 4 associated associate VBN cord-335975-m6lkrehi 1996 5 with with IN cord-335975-m6lkrehi 1996 6 a a DT cord-335975-m6lkrehi 1996 7 poor poor JJ cord-335975-m6lkrehi 1996 8 satisfaction satisfaction NN cord-335975-m6lkrehi 1996 9 ( ( -LRB- cord-335975-m6lkrehi 1996 10 participation participation NN cord-335975-m6lkrehi 1996 11 to to IN cord-335975-m6lkrehi 1996 12 the the DT cord-335975-m6lkrehi 1996 13 care care NN cord-335975-m6lkrehi 1996 14 , , , cord-335975-m6lkrehi 1996 15 identification identification NN cord-335975-m6lkrehi 1996 16 and and CC cord-335975-m6lkrehi 1996 17 availability availability NN cord-335975-m6lkrehi 1996 18 of of IN cord-335975-m6lkrehi 1996 19 the the DT cord-335975-m6lkrehi 1996 20 caregivers caregiver NNS cord-335975-m6lkrehi 1996 21 ) ) -RRB- cord-335975-m6lkrehi 1996 22 . . . cord-335975-m6lkrehi 1997 1 Conclusion conclusion NN cord-335975-m6lkrehi 1997 2 : : : cord-335975-m6lkrehi 1998 1 The the DT cord-335975-m6lkrehi 1998 2 implementation implementation NN cord-335975-m6lkrehi 1998 3 of of IN cord-335975-m6lkrehi 1998 4 the the DT cord-335975-m6lkrehi 1998 5 OpinionFamily OpinionFamily NNP cord-335975-m6lkrehi 1998 6 tool tool NN cord-335975-m6lkrehi 1998 7 allowed allow VBD cord-335975-m6lkrehi 1998 8 a a DT cord-335975-m6lkrehi 1998 9 continuous continuous JJ cord-335975-m6lkrehi 1998 10 evaluation evaluation NN cord-335975-m6lkrehi 1998 11 of of IN cord-335975-m6lkrehi 1998 12 the the DT cord-335975-m6lkrehi 1998 13 satisfaction satisfaction NN cord-335975-m6lkrehi 1998 14 of of IN cord-335975-m6lkrehi 1998 15 the the DT cord-335975-m6lkrehi 1998 16 critically critically RB cord-335975-m6lkrehi 1998 17 ill ill JJ cord-335975-m6lkrehi 1998 18 patients patient NNS cord-335975-m6lkrehi 1998 19 ' ' POS cord-335975-m6lkrehi 1998 20 proxies proxy NNS cord-335975-m6lkrehi 1998 21 . . . cord-335975-m6lkrehi 1999 1 A a DT cord-335975-m6lkrehi 1999 2 systematic systematic JJ cord-335975-m6lkrehi 1999 3 implementation implementation NN cord-335975-m6lkrehi 1999 4 of of IN cord-335975-m6lkrehi 1999 5 this this DT cord-335975-m6lkrehi 1999 6 tool tool NN cord-335975-m6lkrehi 1999 7 in in IN cord-335975-m6lkrehi 1999 8 the the DT cord-335975-m6lkrehi 1999 9 ICUs icu NNS cord-335975-m6lkrehi 1999 10 may may MD cord-335975-m6lkrehi 1999 11 be be VB cord-335975-m6lkrehi 1999 12 useful useful JJ cord-335975-m6lkrehi 1999 13 to to IN cord-335975-m6lkrehi 1999 14 the the DT cord-335975-m6lkrehi 1999 15 caregivers caregiver NNS cord-335975-m6lkrehi 1999 16 for for IN cord-335975-m6lkrehi 1999 17 a a DT cord-335975-m6lkrehi 1999 18 better well JJR cord-335975-m6lkrehi 1999 19 understanding understanding NN cord-335975-m6lkrehi 1999 20 of of IN cord-335975-m6lkrehi 1999 21 the the DT cord-335975-m6lkrehi 1999 22 needs need NNS cord-335975-m6lkrehi 1999 23 of of IN cord-335975-m6lkrehi 1999 24 the the DT cord-335975-m6lkrehi 1999 25 proxies proxy NNS cord-335975-m6lkrehi 1999 26 . . . cord-335975-m6lkrehi 2000 1 In in IN cord-335975-m6lkrehi 2000 2 addition addition NN cord-335975-m6lkrehi 2000 3 , , , cord-335975-m6lkrehi 2000 4 this this DT cord-335975-m6lkrehi 2000 5 tool tool NN cord-335975-m6lkrehi 2000 6 may may MD cord-335975-m6lkrehi 2000 7 allow allow VB cord-335975-m6lkrehi 2000 8 rapid rapid JJ cord-335975-m6lkrehi 2000 9 changes change NNS cord-335975-m6lkrehi 2000 10 in in IN cord-335975-m6lkrehi 2000 11 ICU ICU NNP cord-335975-m6lkrehi 2000 12 organizations organization NNS cord-335975-m6lkrehi 2000 13 and and CC cord-335975-m6lkrehi 2000 14 behaviours behaviour NNS cord-335975-m6lkrehi 2000 15 to to TO cord-335975-m6lkrehi 2000 16 improve improve VB cord-335975-m6lkrehi 2000 17 the the DT cord-335975-m6lkrehi 2000 18 proxies proxy NNS cord-335975-m6lkrehi 2000 19 ' ' POS cord-335975-m6lkrehi 2000 20 satisfaction satisfaction NN cord-335975-m6lkrehi 2000 21 , , , cord-335975-m6lkrehi 2000 22 which which WDT cord-335975-m6lkrehi 2000 23 may may MD cord-335975-m6lkrehi 2000 24 ultimately ultimately RB cord-335975-m6lkrehi 2000 25 , , , cord-335975-m6lkrehi 2000 26 improve improve VB cord-335975-m6lkrehi 2000 27 the the DT cord-335975-m6lkrehi 2000 28 care care NN cord-335975-m6lkrehi 2000 29 of of IN cord-335975-m6lkrehi 2000 30 patients patient NNS cord-335975-m6lkrehi 2000 31 . . . cord-335975-m6lkrehi 2001 1 Many many JJ cord-335975-m6lkrehi 2001 2 factors factor NNS cord-335975-m6lkrehi 2001 3 influence influence VBP cord-335975-m6lkrehi 2001 4 end end NN cord-335975-m6lkrehi 2001 5 - - HYPH cord-335975-m6lkrehi 2001 6 of of IN cord-335975-m6lkrehi 2001 7 - - HYPH cord-335975-m6lkrehi 2001 8 life life NN cord-335975-m6lkrehi 2001 9 decisions decision NNS cord-335975-m6lkrehi 2001 10 ( ( -LRB- cord-335975-m6lkrehi 2001 11 EOL EOL NNP cord-335975-m6lkrehi 2001 12 ) ) -RRB- cord-335975-m6lkrehi 2001 13 . . . cord-335975-m6lkrehi 2002 1 We -PRON- PRP cord-335975-m6lkrehi 2002 2 describe describe VBP cord-335975-m6lkrehi 2002 3 EOL EOL NNP cord-335975-m6lkrehi 2002 4 decisions decision NNS cord-335975-m6lkrehi 2002 5 in in IN cord-335975-m6lkrehi 2002 6 patients patient NNS cord-335975-m6lkrehi 2002 7 with with IN cord-335975-m6lkrehi 2002 8 acute acute JJ cord-335975-m6lkrehi 2002 9 respiratory respiratory JJ cord-335975-m6lkrehi 2002 10 failure failure NN cord-335975-m6lkrehi 2002 11 and and CC cord-335975-m6lkrehi 2002 12 their -PRON- PRP$ cord-335975-m6lkrehi 2002 13 impact impact NN cord-335975-m6lkrehi 2002 14 on on IN cord-335975-m6lkrehi 2002 15 patients patient NNS cord-335975-m6lkrehi 2002 16 ' ' POS cord-335975-m6lkrehi 2002 17 prognosis prognosis NN cord-335975-m6lkrehi 2002 18 . . . cord-335975-m6lkrehi 2003 1 Patients patient NNS cord-335975-m6lkrehi 2003 2 and and CC cord-335975-m6lkrehi 2003 3 methods method NNS cord-335975-m6lkrehi 2003 4 : : : cord-335975-m6lkrehi 2003 5 An an DT cord-335975-m6lkrehi 2003 6 international international JJ cord-335975-m6lkrehi 2003 7 observational observational JJ cord-335975-m6lkrehi 2003 8 study study NN cord-335975-m6lkrehi 2003 9 included include VBD cord-335975-m6lkrehi 2003 10 all all DT cord-335975-m6lkrehi 2003 11 patients patient NNS cord-335975-m6lkrehi 2003 12 with with IN cord-335975-m6lkrehi 2003 13 acute acute JJ cord-335975-m6lkrehi 2003 14 respiratory respiratory JJ cord-335975-m6lkrehi 2003 15 distress distress NN cord-335975-m6lkrehi 2003 16 over over IN cord-335975-m6lkrehi 2003 17 a a DT cord-335975-m6lkrehi 2003 18 1-month 1-month CD cord-335975-m6lkrehi 2003 19 period period NN cord-335975-m6lkrehi 2003 20 . . . cord-335975-m6lkrehi 2004 1 459 459 CD cord-335975-m6lkrehi 2004 2 ICU ICU NNP cord-335975-m6lkrehi 2004 3 in in IN cord-335975-m6lkrehi 2004 4 50 50 CD cord-335975-m6lkrehi 2004 5 countries country NNS cord-335975-m6lkrehi 2004 6 were be VBD cord-335975-m6lkrehi 2004 7 involved involve VBN cord-335975-m6lkrehi 2004 8 . . . cord-335975-m6lkrehi 2005 1 Demographic demographic JJ cord-335975-m6lkrehi 2005 2 , , , cord-335975-m6lkrehi 2005 3 clinical clinical JJ cord-335975-m6lkrehi 2005 4 and and CC cord-335975-m6lkrehi 2005 5 biological biological JJ cord-335975-m6lkrehi 2005 6 data datum NNS cord-335975-m6lkrehi 2005 7 were be VBD cord-335975-m6lkrehi 2005 8 compared compare VBN cord-335975-m6lkrehi 2005 9 between between IN cord-335975-m6lkrehi 2005 10 patients patient NNS cord-335975-m6lkrehi 2005 11 with with IN cord-335975-m6lkrehi 2005 12 and and CC cord-335975-m6lkrehi 2005 13 without without IN cord-335975-m6lkrehi 2005 14 decision decision NN cord-335975-m6lkrehi 2005 15 of of IN cord-335975-m6lkrehi 2005 16 LST LST NNP cord-335975-m6lkrehi 2005 17 limitation limitation NN cord-335975-m6lkrehi 2005 18 . . . cord-335975-m6lkrehi 2006 1 We -PRON- PRP cord-335975-m6lkrehi 2006 2 also also RB cord-335975-m6lkrehi 2006 3 compared compare VBD cord-335975-m6lkrehi 2006 4 surviving survive VBG cord-335975-m6lkrehi 2006 5 patients patient NNS cord-335975-m6lkrehi 2006 6 after after IN cord-335975-m6lkrehi 2006 7 LST LST NNP cord-335975-m6lkrehi 2006 8 limitation limitation NN cord-335975-m6lkrehi 2006 9 decision decision NN cord-335975-m6lkrehi 2006 10 to to IN cord-335975-m6lkrehi 2006 11 those those DT cord-335975-m6lkrehi 2006 12 who who WP cord-335975-m6lkrehi 2006 13 eventually eventually RB cord-335975-m6lkrehi 2006 14 died die VBD cord-335975-m6lkrehi 2006 15 . . . cord-335975-m6lkrehi 2007 1 Results result NNS cord-335975-m6lkrehi 2007 2 : : : cord-335975-m6lkrehi 2008 1 Among among IN cord-335975-m6lkrehi 2008 2 the the DT cord-335975-m6lkrehi 2008 3 4041 4041 CD cord-335975-m6lkrehi 2008 4 patients patient NNS cord-335975-m6lkrehi 2008 5 , , , cord-335975-m6lkrehi 2008 6 mortality mortality NN cord-335975-m6lkrehi 2008 7 was be VBD cord-335975-m6lkrehi 2008 8 37.2 37.2 CD cord-335975-m6lkrehi 2008 9 % % NN cord-335975-m6lkrehi 2008 10 . . . cord-335975-m6lkrehi 2009 1 A a DT cord-335975-m6lkrehi 2009 2 decision decision NN cord-335975-m6lkrehi 2009 3 of of IN cord-335975-m6lkrehi 2009 4 LST LST NNP cord-335975-m6lkrehi 2009 5 limitation limitation NN cord-335975-m6lkrehi 2009 6 was be VBD cord-335975-m6lkrehi 2009 7 reported report VBN cord-335975-m6lkrehi 2009 8 in in IN cord-335975-m6lkrehi 2009 9 948 948 CD cord-335975-m6lkrehi 2009 10 patients patient NNS cord-335975-m6lkrehi 2009 11 ( ( -LRB- cord-335975-m6lkrehi 2009 12 23.4 23.4 CD cord-335975-m6lkrehi 2009 13 % % NN cord-335975-m6lkrehi 2009 14 ) ) -RRB- cord-335975-m6lkrehi 2009 15 . . . cord-335975-m6lkrehi 2010 1 In in IN cord-335975-m6lkrehi 2010 2 univariate univariate JJ cord-335975-m6lkrehi 2010 3 analysis analysis NN cord-335975-m6lkrehi 2010 4 , , , cord-335975-m6lkrehi 2010 5 patients patient NNS cord-335975-m6lkrehi 2010 6 with with IN cord-335975-m6lkrehi 2010 7 LST LST NNP cord-335975-m6lkrehi 2010 8 limitation limitation NN cord-335975-m6lkrehi 2010 9 decision decision NN cord-335975-m6lkrehi 2010 10 were be VBD cord-335975-m6lkrehi 2010 11 older old JJR cord-335975-m6lkrehi 2010 12 and and CC cord-335975-m6lkrehi 2010 13 more more RBR cord-335975-m6lkrehi 2010 14 frequently frequently RB cord-335975-m6lkrehi 2010 15 hospitalized hospitalize VBN cord-335975-m6lkrehi 2010 16 for for IN cord-335975-m6lkrehi 2010 17 a a DT cord-335975-m6lkrehi 2010 18 medical medical JJ cord-335975-m6lkrehi 2010 19 condition condition NN cord-335975-m6lkrehi 2010 20 , , , cord-335975-m6lkrehi 2010 21 had have VBD cord-335975-m6lkrehi 2010 22 a a DT cord-335975-m6lkrehi 2010 23 lower low JJR cord-335975-m6lkrehi 2010 24 body body NN cord-335975-m6lkrehi 2010 25 weight weight NN cord-335975-m6lkrehi 2010 26 , , , cord-335975-m6lkrehi 2010 27 a a DT cord-335975-m6lkrehi 2010 28 higher high JJR cord-335975-m6lkrehi 2010 29 SOFA sofa NN cord-335975-m6lkrehi 2010 30 score score NN cord-335975-m6lkrehi 2010 31 , , , cord-335975-m6lkrehi 2010 32 and and CC cord-335975-m6lkrehi 2010 33 presented present VBD cord-335975-m6lkrehi 2010 34 active active JJ cord-335975-m6lkrehi 2010 35 neoplasia neoplasia NN cord-335975-m6lkrehi 2010 36 immunosuppression immunosuppression NN cord-335975-m6lkrehi 2010 37 or or CC cord-335975-m6lkrehi 2010 38 chronic chronic JJ cord-335975-m6lkrehi 2010 39 liver liver NN cord-335975-m6lkrehi 2010 40 failure failure NN cord-335975-m6lkrehi 2010 41 more more RBR cord-335975-m6lkrehi 2010 42 frequently frequently RB cord-335975-m6lkrehi 2011 1 ( ( -LRB- cord-335975-m6lkrehi 2011 2 p p NN cord-335975-m6lkrehi 2011 3 < < XX cord-335975-m6lkrehi 2011 4 0.001 0.001 CD cord-335975-m6lkrehi 2011 5 for for IN cord-335975-m6lkrehi 2011 6 all all DT cord-335975-m6lkrehi 2011 7 ) ) -RRB- cord-335975-m6lkrehi 2011 8 . . . cord-335975-m6lkrehi 2012 1 Patients patient NNS cord-335975-m6lkrehi 2012 2 admitted admit VBN cord-335975-m6lkrehi 2012 3 after after IN cord-335975-m6lkrehi 2012 4 trauma trauma NN cord-335975-m6lkrehi 2012 5 , , , cord-335975-m6lkrehi 2012 6 drug drug NN cord-335975-m6lkrehi 2012 7 overdose overdose NN cord-335975-m6lkrehi 2012 8 or or CC cord-335975-m6lkrehi 2012 9 pulmonary pulmonary JJ cord-335975-m6lkrehi 2012 10 contusion contusion NN cord-335975-m6lkrehi 2012 11 were be VBD cord-335975-m6lkrehi 2012 12 less less RBR cord-335975-m6lkrehi 2012 13 subject subject JJ cord-335975-m6lkrehi 2012 14 to to TO cord-335975-m6lkrehi 2012 15 have have VB cord-335975-m6lkrehi 2012 16 an an DT cord-335975-m6lkrehi 2012 17 LST LST NNP cord-335975-m6lkrehi 2012 18 limitation limitation NN cord-335975-m6lkrehi 2012 19 decision decision NN cord-335975-m6lkrehi 2012 20 ( ( -LRB- cord-335975-m6lkrehi 2012 21 p p NN cord-335975-m6lkrehi 2012 22 < < XX cord-335975-m6lkrehi 2012 23 0.001 0.001 CD cord-335975-m6lkrehi 2012 24 ) ) -RRB- cord-335975-m6lkrehi 2012 25 . . . cord-335975-m6lkrehi 2013 1 In in IN cord-335975-m6lkrehi 2013 2 contrast contrast NN cord-335975-m6lkrehi 2013 3 , , , cord-335975-m6lkrehi 2013 4 patients patient NNS cord-335975-m6lkrehi 2013 5 with with IN cord-335975-m6lkrehi 2013 6 non non JJ cord-335975-m6lkrehi 2013 7 - - JJ cord-335975-m6lkrehi 2013 8 cardiogenic cardiogenic JJ cord-335975-m6lkrehi 2013 9 shock shock NN cord-335975-m6lkrehi 2013 10 were be VBD cord-335975-m6lkrehi 2013 11 more more RBR cord-335975-m6lkrehi 2013 12 subject subject JJ cord-335975-m6lkrehi 2013 13 to to IN cord-335975-m6lkrehi 2013 14 these these DT cord-335975-m6lkrehi 2013 15 decisions decision NNS cord-335975-m6lkrehi 2013 16 ( ( -LRB- cord-335975-m6lkrehi 2013 17 p p NN cord-335975-m6lkrehi 2013 18 = = SYM cord-335975-m6lkrehi 2013 19 0.018 0.018 CD cord-335975-m6lkrehi 2013 20 ) ) -RRB- cord-335975-m6lkrehi 2013 21 . . . cord-335975-m6lkrehi 2014 1 EOL eol NN cord-335975-m6lkrehi 2014 2 decisions decision NNS cord-335975-m6lkrehi 2014 3 were be VBD cord-335975-m6lkrehi 2014 4 less less RBR cord-335975-m6lkrehi 2014 5 frequent frequent JJ cord-335975-m6lkrehi 2014 6 in in IN cord-335975-m6lkrehi 2014 7 lower low JJR cord-335975-m6lkrehi 2014 8 - - HYPH cord-335975-m6lkrehi 2014 9 middle middle JJ cord-335975-m6lkrehi 2014 10 income income NN cord-335975-m6lkrehi 2014 11 countries country NNS cord-335975-m6lkrehi 2014 12 as as IN cord-335975-m6lkrehi 2014 13 compared compare VBN cord-335975-m6lkrehi 2014 14 to to IN cord-335975-m6lkrehi 2014 15 high high JJ cord-335975-m6lkrehi 2014 16 and and CC cord-335975-m6lkrehi 2014 17 middle middle JJ cord-335975-m6lkrehi 2014 18 - - HYPH cord-335975-m6lkrehi 2014 19 high high JJ cord-335975-m6lkrehi 2014 20 income income NN cord-335975-m6lkrehi 2014 21 countries country NNS cord-335975-m6lkrehi 2014 22 ( ( -LRB- cord-335975-m6lkrehi 2014 23 p p NN cord-335975-m6lkrehi 2014 24 < < XX cord-335975-m6lkrehi 2014 25 0.001 0.001 CD cord-335975-m6lkrehi 2014 26 ) ) -RRB- cord-335975-m6lkrehi 2014 27 . . . cord-335975-m6lkrehi 2015 1 Multivariate multivariate JJ cord-335975-m6lkrehi 2015 2 analysis analysis NN cord-335975-m6lkrehi 2015 3 will will MD cord-335975-m6lkrehi 2015 4 be be VB cord-335975-m6lkrehi 2015 5 presented present VBN cord-335975-m6lkrehi 2015 6 . . . cord-335975-m6lkrehi 2016 1 Among among IN cord-335975-m6lkrehi 2016 2 948 948 CD cord-335975-m6lkrehi 2016 3 patients patient NNS cord-335975-m6lkrehi 2016 4 with with IN cord-335975-m6lkrehi 2016 5 an an DT cord-335975-m6lkrehi 2016 6 LST LST NNP cord-335975-m6lkrehi 2016 7 limitation limitation NN cord-335975-m6lkrehi 2016 8 decision decision NN cord-335975-m6lkrehi 2016 9 , , , cord-335975-m6lkrehi 2016 10 148 148 CD cord-335975-m6lkrehi 2016 11 survived survive VBD cord-335975-m6lkrehi 2016 12 ( ( -LRB- cord-335975-m6lkrehi 2016 13 15.6 15.6 CD cord-335975-m6lkrehi 2016 14 % % NN cord-335975-m6lkrehi 2016 15 ) ) -RRB- cord-335975-m6lkrehi 2016 16 . . . cord-335975-m6lkrehi 2017 1 Mortality mortality NN cord-335975-m6lkrehi 2017 2 was be VBD cord-335975-m6lkrehi 2017 3 higher high JJR cord-335975-m6lkrehi 2017 4 in in IN cord-335975-m6lkrehi 2017 5 this this DT cord-335975-m6lkrehi 2017 6 group group NN cord-335975-m6lkrehi 2017 7 than than IN cord-335975-m6lkrehi 2017 8 in in IN cord-335975-m6lkrehi 2017 9 the the DT cord-335975-m6lkrehi 2017 10 whole whole JJ cord-335975-m6lkrehi 2017 11 study study NN cord-335975-m6lkrehi 2017 12 population population NN cord-335975-m6lkrehi 2017 13 ( ( -LRB- cord-335975-m6lkrehi 2017 14 p p NN cord-335975-m6lkrehi 2017 15 = = SYM cord-335975-m6lkrehi 2017 16 0.001 0.001 CD cord-335975-m6lkrehi 2017 17 ) ) -RRB- cord-335975-m6lkrehi 2017 18 . . . cord-335975-m6lkrehi 2018 1 In in IN cord-335975-m6lkrehi 2018 2 univariate univariate JJ cord-335975-m6lkrehi 2018 3 analysis analysis NN cord-335975-m6lkrehi 2018 4 , , , cord-335975-m6lkrehi 2018 5 death death NN cord-335975-m6lkrehi 2018 6 after after IN cord-335975-m6lkrehi 2018 7 decision decision NN cord-335975-m6lkrehi 2018 8 of of IN cord-335975-m6lkrehi 2018 9 LST LST NNP cord-335975-m6lkrehi 2018 10 limitation limitation NN cord-335975-m6lkrehi 2018 11 was be VBD cord-335975-m6lkrehi 2018 12 associated associate VBN cord-335975-m6lkrehi 2018 13 with with IN cord-335975-m6lkrehi 2018 14 admission admission NN cord-335975-m6lkrehi 2018 15 for for IN cord-335975-m6lkrehi 2018 16 a a DT cord-335975-m6lkrehi 2018 17 medical medical JJ cord-335975-m6lkrehi 2018 18 condition condition NN cord-335975-m6lkrehi 2018 19 ( ( -LRB- cord-335975-m6lkrehi 2018 20 p p NN cord-335975-m6lkrehi 2018 21 = = SYM cord-335975-m6lkrehi 2018 22 0.02 0.02 CD cord-335975-m6lkrehi 2018 23 ) ) -RRB- cord-335975-m6lkrehi 2018 24 , , , cord-335975-m6lkrehi 2018 25 severe severe JJ cord-335975-m6lkrehi 2018 26 ARDS ARDS NNP cord-335975-m6lkrehi 2018 27 , , , cord-335975-m6lkrehi 2018 28 higher high JJR cord-335975-m6lkrehi 2018 29 inspiratory inspiratory JJ cord-335975-m6lkrehi 2018 30 pressure pressure NN cord-335975-m6lkrehi 2018 31 , , , cord-335975-m6lkrehi 2018 32 non non JJ cord-335975-m6lkrehi 2018 33 - - JJ cord-335975-m6lkrehi 2018 34 cardiogenic cardiogenic JJ cord-335975-m6lkrehi 2018 35 shock shock NN cord-335975-m6lkrehi 2018 36 , , , cord-335975-m6lkrehi 2018 37 higher high JJR cord-335975-m6lkrehi 2018 38 SOFA sofa NN cord-335975-m6lkrehi 2018 39 score score NN cord-335975-m6lkrehi 2018 40 with with IN cord-335975-m6lkrehi 2018 41 or or CC cord-335975-m6lkrehi 2018 42 without without IN cord-335975-m6lkrehi 2018 43 respiratory respiratory JJ cord-335975-m6lkrehi 2018 44 component component NN cord-335975-m6lkrehi 2018 45 and and CC cord-335975-m6lkrehi 2018 46 chronic chronic JJ cord-335975-m6lkrehi 2018 47 liver liver NN cord-335975-m6lkrehi 2018 48 failure failure NN cord-335975-m6lkrehi 2018 49 ( ( -LRB- cord-335975-m6lkrehi 2018 50 p p NN cord-335975-m6lkrehi 2018 51 < < XX cord-335975-m6lkrehi 2018 52 = = SYM cord-335975-m6lkrehi 2018 53 0.001 0.001 CD cord-335975-m6lkrehi 2018 54 for for IN cord-335975-m6lkrehi 2018 55 all all DT cord-335975-m6lkrehi 2018 56 ) ) -RRB- cord-335975-m6lkrehi 2018 57 . . . cord-335975-m6lkrehi 2019 1 On on IN cord-335975-m6lkrehi 2019 2 the the DT cord-335975-m6lkrehi 2019 3 contrary contrary NN cord-335975-m6lkrehi 2019 4 , , , cord-335975-m6lkrehi 2019 5 admission admission NN cord-335975-m6lkrehi 2019 6 for for IN cord-335975-m6lkrehi 2019 7 trauma trauma NN cord-335975-m6lkrehi 2019 8 was be VBD cord-335975-m6lkrehi 2019 9 associated associate VBN cord-335975-m6lkrehi 2019 10 with with IN cord-335975-m6lkrehi 2019 11 survival survival NN cord-335975-m6lkrehi 2019 12 ( ( -LRB- cord-335975-m6lkrehi 2019 13 p p NN cord-335975-m6lkrehi 2019 14 = = SYM cord-335975-m6lkrehi 2019 15 0.001 0.001 CD cord-335975-m6lkrehi 2019 16 ) ) -RRB- cord-335975-m6lkrehi 2019 17 . . . cord-335975-m6lkrehi 2020 1 Regarding regard VBG cord-335975-m6lkrehi 2020 2 the the DT cord-335975-m6lkrehi 2020 3 1503 1503 CD cord-335975-m6lkrehi 2020 4 patients patient NNS cord-335975-m6lkrehi 2020 5 who who WP cord-335975-m6lkrehi 2020 6 died die VBD cord-335975-m6lkrehi 2020 7 during during IN cord-335975-m6lkrehi 2020 8 their -PRON- PRP$ cord-335975-m6lkrehi 2020 9 hospital hospital NN cord-335975-m6lkrehi 2020 10 stay stay NN cord-335975-m6lkrehi 2020 11 , , , cord-335975-m6lkrehi 2020 12 703 703 CD cord-335975-m6lkrehi 2020 13 did do VBD cord-335975-m6lkrehi 2020 14 not not RB cord-335975-m6lkrehi 2020 15 receive receive VB cord-335975-m6lkrehi 2020 16 a a DT cord-335975-m6lkrehi 2020 17 decision decision NN cord-335975-m6lkrehi 2020 18 of of IN cord-335975-m6lkrehi 2020 19 LST LST NNP cord-335975-m6lkrehi 2020 20 limitation limitation NN cord-335975-m6lkrehi 2020 21 ( ( -LRB- cord-335975-m6lkrehi 2020 22 46.8 46.8 CD cord-335975-m6lkrehi 2020 23 % % NN cord-335975-m6lkrehi 2020 24 ) ) -RRB- cord-335975-m6lkrehi 2020 25 . . . cord-335975-m6lkrehi 2021 1 Decision decision NN cord-335975-m6lkrehi 2021 2 of of IN cord-335975-m6lkrehi 2021 3 LST LST NNP cord-335975-m6lkrehi 2021 4 limitation limitation NN cord-335975-m6lkrehi 2021 5 was be VBD cord-335975-m6lkrehi 2021 6 more more RBR cord-335975-m6lkrehi 2021 7 frequent frequent JJ cord-335975-m6lkrehi 2021 8 in in IN cord-335975-m6lkrehi 2021 9 older old JJR cord-335975-m6lkrehi 2021 10 patients patient NNS cord-335975-m6lkrehi 2021 11 ( ( -LRB- cord-335975-m6lkrehi 2021 12 p p NN cord-335975-m6lkrehi 2021 13 < < XX cord-335975-m6lkrehi 2021 14 0.001 0.001 CD cord-335975-m6lkrehi 2021 15 ) ) -RRB- cord-335975-m6lkrehi 2021 16 and and CC cord-335975-m6lkrehi 2021 17 in in IN cord-335975-m6lkrehi 2021 18 high high JJ cord-335975-m6lkrehi 2021 19 - - HYPH cord-335975-m6lkrehi 2021 20 income income NN cord-335975-m6lkrehi 2021 21 countries country NNS cord-335975-m6lkrehi 2021 22 . . . cord-335975-m6lkrehi 2022 1 Conclusion conclusion NN cord-335975-m6lkrehi 2022 2 : : : cord-335975-m6lkrehi 2023 1 Decisions decision NNS cord-335975-m6lkrehi 2023 2 of of IN cord-335975-m6lkrehi 2023 3 LST LST NNP cord-335975-m6lkrehi 2023 4 limitation limitation NN cord-335975-m6lkrehi 2023 5 are be VBP cord-335975-m6lkrehi 2023 6 frequent frequent JJ cord-335975-m6lkrehi 2023 7 in in IN cord-335975-m6lkrehi 2023 8 the the DT cord-335975-m6lkrehi 2023 9 ICU ICU NNP cord-335975-m6lkrehi 2023 10 , , , cord-335975-m6lkrehi 2023 11 and and CC cord-335975-m6lkrehi 2023 12 are be VBP cord-335975-m6lkrehi 2023 13 associated associate VBN cord-335975-m6lkrehi 2023 14 with with IN cord-335975-m6lkrehi 2023 15 increased increase VBN cord-335975-m6lkrehi 2023 16 age age NN cord-335975-m6lkrehi 2023 17 and and CC cord-335975-m6lkrehi 2023 18 medical medical JJ cord-335975-m6lkrehi 2023 19 severity severity NN cord-335975-m6lkrehi 2023 20 . . . cord-335975-m6lkrehi 2024 1 However however RB cord-335975-m6lkrehi 2024 2 , , , cord-335975-m6lkrehi 2024 3 a a DT cord-335975-m6lkrehi 2024 4 significant significant JJ cord-335975-m6lkrehi 2024 5 percentage percentage NN cord-335975-m6lkrehi 2024 6 of of IN cord-335975-m6lkrehi 2024 7 these these DT cord-335975-m6lkrehi 2024 8 patients patient NNS cord-335975-m6lkrehi 2024 9 survived survive VBD cord-335975-m6lkrehi 2024 10 . . . cord-335975-m6lkrehi 2025 1 Interestingly interestingly RB cord-335975-m6lkrehi 2025 2 , , , cord-335975-m6lkrehi 2025 3 almost almost RB cord-335975-m6lkrehi 2025 4 half half NN cord-335975-m6lkrehi 2025 5 of of IN cord-335975-m6lkrehi 2025 6 the the DT cord-335975-m6lkrehi 2025 7 patients patient NNS cord-335975-m6lkrehi 2025 8 who who WP cord-335975-m6lkrehi 2025 9 eventually eventually RB cord-335975-m6lkrehi 2025 10 died die VBD cord-335975-m6lkrehi 2025 11 during during IN cord-335975-m6lkrehi 2025 12 their -PRON- PRP$ cord-335975-m6lkrehi 2025 13 hospital hospital NN cord-335975-m6lkrehi 2025 14 stay stay NN cord-335975-m6lkrehi 2025 15 had have VBD cord-335975-m6lkrehi 2025 16 not not RB cord-335975-m6lkrehi 2025 17 been be VBN cord-335975-m6lkrehi 2025 18 subject subject JJ cord-335975-m6lkrehi 2025 19 of of IN cord-335975-m6lkrehi 2025 20 a a DT cord-335975-m6lkrehi 2025 21 decision decision NN cord-335975-m6lkrehi 2025 22 of of IN cord-335975-m6lkrehi 2025 23 LST LST NNP cord-335975-m6lkrehi 2025 24 limitation limitation NN cord-335975-m6lkrehi 2025 25 . . . cord-335975-m6lkrehi 2026 1 Evaluation evaluation NN cord-335975-m6lkrehi 2026 2 of of IN cord-335975-m6lkrehi 2026 3 the the DT cord-335975-m6lkrehi 2026 4 decision decision NN cord-335975-m6lkrehi 2026 5 - - HYPH cord-335975-m6lkrehi 2026 6 making make VBG cord-335975-m6lkrehi 2026 7 process process NN cord-335975-m6lkrehi 2026 8 leading lead VBG cord-335975-m6lkrehi 2026 9 to to IN cord-335975-m6lkrehi 2026 10 a a DT cord-335975-m6lkrehi 2026 11 decision decision NN cord-335975-m6lkrehi 2026 12 not not RB cord-335975-m6lkrehi 2026 13 to to TO cord-335975-m6lkrehi 2026 14 readmit readmit VB cord-335975-m6lkrehi 2026 15 a a DT cord-335975-m6lkrehi 2026 16 patient patient NN cord-335975-m6lkrehi 2026 17 to to IN cord-335975-m6lkrehi 2026 18 the the DT cord-335975-m6lkrehi 2026 19 intensive intensive JJ cord-335975-m6lkrehi 2026 20 care care NN cord-335975-m6lkrehi 2026 21 unit unit NN cord-335975-m6lkrehi 2026 22 during during IN cord-335975-m6lkrehi 2026 23 a a DT cord-335975-m6lkrehi 2026 24 same same JJ cord-335975-m6lkrehi 2026 25 hospital hospital NN cord-335975-m6lkrehi 2026 26 stay stay NN cord-335975-m6lkrehi 2027 1 Introduction introduction NN cord-335975-m6lkrehi 2027 2 : : : cord-335975-m6lkrehi 2028 1 The the DT cord-335975-m6lkrehi 2028 2 risk risk NN cord-335975-m6lkrehi 2028 3 - - HYPH cord-335975-m6lkrehi 2028 4 benefit benefit NN cord-335975-m6lkrehi 2028 5 ratio ratio NN cord-335975-m6lkrehi 2028 6 of of IN cord-335975-m6lkrehi 2028 7 ( ( -LRB- cord-335975-m6lkrehi 2028 8 re-)admission re-)admission NNP cord-335975-m6lkrehi 2028 9 to to IN cord-335975-m6lkrehi 2028 10 the the DT cord-335975-m6lkrehi 2028 11 intensive intensive JJ cord-335975-m6lkrehi 2028 12 care care NN cord-335975-m6lkrehi 2028 13 unit unit NN cord-335975-m6lkrehi 2028 14 ( ( -LRB- cord-335975-m6lkrehi 2028 15 ICU ICU NNP cord-335975-m6lkrehi 2028 16 ) ) -RRB- cord-335975-m6lkrehi 2028 17 has have VBZ cord-335975-m6lkrehi 2028 18 been be VBN cord-335975-m6lkrehi 2028 19 widely widely RB cord-335975-m6lkrehi 2028 20 discussed discuss VBN cord-335975-m6lkrehi 2028 21 in in IN cord-335975-m6lkrehi 2028 22 the the DT cord-335975-m6lkrehi 2028 23 literature literature NN cord-335975-m6lkrehi 2028 24 . . . cord-335975-m6lkrehi 2029 1 However however RB cord-335975-m6lkrehi 2029 2 , , , cord-335975-m6lkrehi 2029 3 the the DT cord-335975-m6lkrehi 2029 4 ethics ethic NNS cord-335975-m6lkrehi 2029 5 of of IN cord-335975-m6lkrehi 2029 6 non non JJ cord-335975-m6lkrehi 2029 7 - - JJ cord-335975-m6lkrehi 2029 8 readmission readmission NN cord-335975-m6lkrehi 2029 9 during during IN cord-335975-m6lkrehi 2029 10 a a DT cord-335975-m6lkrehi 2029 11 single single JJ cord-335975-m6lkrehi 2029 12 hospital hospital NN cord-335975-m6lkrehi 2029 13 stay stay NN cord-335975-m6lkrehi 2029 14 have have VBP cord-335975-m6lkrehi 2029 15 not not RB cord-335975-m6lkrehi 2029 16 been be VBN cord-335975-m6lkrehi 2029 17 widely widely RB cord-335975-m6lkrehi 2029 18 addressed address VBN cord-335975-m6lkrehi 2029 19 . . . cord-335975-m6lkrehi 2030 1 A a DT cord-335975-m6lkrehi 2030 2 decision decision NN cord-335975-m6lkrehi 2030 3 not not RB cord-335975-m6lkrehi 2030 4 to to TO cord-335975-m6lkrehi 2030 5 re re VB cord-335975-m6lkrehi 2030 6 - - VB cord-335975-m6lkrehi 2030 7 admit admit VB cord-335975-m6lkrehi 2030 8 a a DT cord-335975-m6lkrehi 2030 9 patient patient NN cord-335975-m6lkrehi 2030 10 to to IN cord-335975-m6lkrehi 2030 11 the the DT cord-335975-m6lkrehi 2030 12 ICU ICU NNP cord-335975-m6lkrehi 2030 13 could could MD cord-335975-m6lkrehi 2030 14 be be VB cord-335975-m6lkrehi 2030 15 seen see VBN cord-335975-m6lkrehi 2030 16 as as IN cord-335975-m6lkrehi 2030 17 a a DT cord-335975-m6lkrehi 2030 18 limitation limitation NN cord-335975-m6lkrehi 2030 19 of of IN cord-335975-m6lkrehi 2030 20 therapy therapy NN cord-335975-m6lkrehi 2030 21 , , , cord-335975-m6lkrehi 2030 22 thus thus RB cord-335975-m6lkrehi 2030 23 falling fall VBG cord-335975-m6lkrehi 2030 24 within within IN cord-335975-m6lkrehi 2030 25 the the DT cord-335975-m6lkrehi 2030 26 scope scope NN cord-335975-m6lkrehi 2030 27 of of IN cord-335975-m6lkrehi 2030 28 the the DT cord-335975-m6lkrehi 2030 29 law law NN cord-335975-m6lkrehi 2030 30 dated date VBD cord-335975-m6lkrehi 2030 31 22 22 CD cord-335975-m6lkrehi 2030 32 April April NNP cord-335975-m6lkrehi 2030 33 2005 2005 CD cord-335975-m6lkrehi 2030 34 , , , cord-335975-m6lkrehi 2030 35 by by IN cord-335975-m6lkrehi 2030 36 denying deny VBG cord-335975-m6lkrehi 2030 37 the the DT cord-335975-m6lkrehi 2030 38 patient patient JJ cord-335975-m6lkrehi 2030 39 access access NN cord-335975-m6lkrehi 2030 40 to to IN cord-335975-m6lkrehi 2030 41 potentially potentially RB cord-335975-m6lkrehi 2030 42 - - HYPH cord-335975-m6lkrehi 2030 43 available available JJ cord-335975-m6lkrehi 2030 44 healthcare healthcare NN cord-335975-m6lkrehi 2030 45 resources resource NNS cord-335975-m6lkrehi 2030 46 . . . cord-335975-m6lkrehi 2031 1 In in IN cord-335975-m6lkrehi 2031 2 this this DT cord-335975-m6lkrehi 2031 3 context context NN cord-335975-m6lkrehi 2031 4 , , , cord-335975-m6lkrehi 2031 5 we -PRON- PRP cord-335975-m6lkrehi 2031 6 aimed aim VBD cord-335975-m6lkrehi 2031 7 to-(1 to-(1 CD cord-335975-m6lkrehi 2031 8 ) ) -RRB- cord-335975-m6lkrehi 2031 9 investigate investigate VBP cord-335975-m6lkrehi 2031 10 whether whether IN cord-335975-m6lkrehi 2031 11 decisions decision NNS cord-335975-m6lkrehi 2031 12 not not RB cord-335975-m6lkrehi 2031 13 to to TO cord-335975-m6lkrehi 2031 14 re re VB cord-335975-m6lkrehi 2031 15 - - VB cord-335975-m6lkrehi 2031 16 admit admit VB cord-335975-m6lkrehi 2031 17 patients patient NNS cord-335975-m6lkrehi 2031 18 to to IN cord-335975-m6lkrehi 2031 19 the the DT cord-335975-m6lkrehi 2031 20 ICU ICU NNP cord-335975-m6lkrehi 2031 21 are be VBP cord-335975-m6lkrehi 2031 22 taken take VBN cord-335975-m6lkrehi 2031 23 in in IN cord-335975-m6lkrehi 2031 24 accordance accordance NN cord-335975-m6lkrehi 2031 25 with with IN cord-335975-m6lkrehi 2031 26 French french JJ cord-335975-m6lkrehi 2031 27 legislation legislation NN cord-335975-m6lkrehi 2031 28 + + CC cord-335975-m6lkrehi 2032 1 and and CC cord-335975-m6lkrehi 2032 2 ( ( -LRB- cord-335975-m6lkrehi 2032 3 2 2 LS cord-335975-m6lkrehi 2032 4 ) ) -RRB- cord-335975-m6lkrehi 2032 5 identify identify VB cord-335975-m6lkrehi 2032 6 the the DT cord-335975-m6lkrehi 2032 7 characteristics characteristic NNS cord-335975-m6lkrehi 2032 8 of of IN cord-335975-m6lkrehi 2032 9 patients patient NNS cord-335975-m6lkrehi 2032 10 concerned concern VBN cord-335975-m6lkrehi 2032 11 by by IN cord-335975-m6lkrehi 2032 12 this this DT cord-335975-m6lkrehi 2032 13 type type NN cord-335975-m6lkrehi 2032 14 of of IN cord-335975-m6lkrehi 2032 15 decision decision NN cord-335975-m6lkrehi 2032 16 . . . cord-335975-m6lkrehi 2033 1 Patients patient NNS cord-335975-m6lkrehi 2033 2 and and CC cord-335975-m6lkrehi 2033 3 methods method NNS cord-335975-m6lkrehi 2033 4 : : : cord-335975-m6lkrehi 2033 5 This this DT cord-335975-m6lkrehi 2033 6 study study NN cord-335975-m6lkrehi 2033 7 was be VBD cord-335975-m6lkrehi 2033 8 based base VBN cord-335975-m6lkrehi 2033 9 on on IN cord-335975-m6lkrehi 2033 10 data datum NNS cord-335975-m6lkrehi 2033 11 from from IN cord-335975-m6lkrehi 2033 12 the the DT cord-335975-m6lkrehi 2033 13 prospective prospective NN cord-335975-m6lkrehi 2033 14 , , , cord-335975-m6lkrehi 2033 15 multicentre multicentre NNP cord-335975-m6lkrehi 2033 16 IVOIRE IVOIRE NNP cord-335975-m6lkrehi 2033 17 cohort cohort NN cord-335975-m6lkrehi 2033 18 ( ( -LRB- cord-335975-m6lkrehi 2033 19 Influence influence NN cord-335975-m6lkrehi 2033 20 of of IN cord-335975-m6lkrehi 2033 21 socio socio JJ cord-335975-m6lkrehi 2033 22 - - HYPH cord-335975-m6lkrehi 2033 23 economic economic JJ cord-335975-m6lkrehi 2033 24 vulnerability vulnerability NN cord-335975-m6lkrehi 2033 25 on on IN cord-335975-m6lkrehi 2033 26 initial initial JJ cord-335975-m6lkrehi 2033 27 severity severity NN cord-335975-m6lkrehi 2033 28 and and CC cord-335975-m6lkrehi 2033 29 prognosis prognosis NN cord-335975-m6lkrehi 2033 30 of of IN cord-335975-m6lkrehi 2033 31 patients patient NNS cord-335975-m6lkrehi 2033 32 admitted admit VBN cord-335975-m6lkrehi 2033 33 to to IN cord-335975-m6lkrehi 2033 34 the the DT cord-335975-m6lkrehi 2033 35 ICU ICU NNP cord-335975-m6lkrehi 2033 36 + + SYM cord-335975-m6lkrehi 2033 37 PHRC PHRC NNP cord-335975-m6lkrehi 2033 38 - - HYPH cord-335975-m6lkrehi 2033 39 IR IR NNP cord-335975-m6lkrehi 2033 40 2012 2012 CD cord-335975-m6lkrehi 2033 41 ) ) -RRB- cord-335975-m6lkrehi 2033 42 . . . cord-335975-m6lkrehi 2034 1 We -PRON- PRP cord-335975-m6lkrehi 2034 2 identified identify VBD cord-335975-m6lkrehi 2034 3 patients patient NNS cord-335975-m6lkrehi 2034 4 included include VBN cord-335975-m6lkrehi 2034 5 in in IN cord-335975-m6lkrehi 2034 6 two two CD cord-335975-m6lkrehi 2034 7 large large JJ cord-335975-m6lkrehi 2034 8 regional regional JJ cord-335975-m6lkrehi 2034 9 university university NN cord-335975-m6lkrehi 2034 10 hospitals hospital NNS cord-335975-m6lkrehi 2034 11 in in IN cord-335975-m6lkrehi 2034 12 the the DT cord-335975-m6lkrehi 2034 13 East East NNP cord-335975-m6lkrehi 2034 14 of of IN cord-335975-m6lkrehi 2034 15 France France NNP cord-335975-m6lkrehi 2034 16 for for IN cord-335975-m6lkrehi 2034 17 whom whom WP cord-335975-m6lkrehi 2034 18 a a DT cord-335975-m6lkrehi 2034 19 decision decision NN cord-335975-m6lkrehi 2034 20 not not RB cord-335975-m6lkrehi 2034 21 to to TO cord-335975-m6lkrehi 2034 22 re re VB cord-335975-m6lkrehi 2034 23 - - VB cord-335975-m6lkrehi 2034 24 admit admit VB cord-335975-m6lkrehi 2034 25 was be VBD cord-335975-m6lkrehi 2034 26 taken take VBN cord-335975-m6lkrehi 2034 27 during during IN cord-335975-m6lkrehi 2034 28 a a DT cord-335975-m6lkrehi 2034 29 single single JJ cord-335975-m6lkrehi 2034 30 hospital hospital NN cord-335975-m6lkrehi 2034 31 stay stay NN cord-335975-m6lkrehi 2034 32 . . . cord-335975-m6lkrehi 2035 1 The the DT cord-335975-m6lkrehi 2035 2 decisionmaking decisionmaking NN cord-335975-m6lkrehi 2035 3 process process NN cord-335975-m6lkrehi 2035 4 was be VBD cord-335975-m6lkrehi 2035 5 evaluated evaluate VBN cord-335975-m6lkrehi 2035 6 based base VBN cord-335975-m6lkrehi 2035 7 on on IN cord-335975-m6lkrehi 2035 8 a a DT cord-335975-m6lkrehi 2035 9 questionnaire questionnaire NN cord-335975-m6lkrehi 2035 10 comprising comprise VBG cord-335975-m6lkrehi 2035 11 13 13 CD cord-335975-m6lkrehi 2035 12 items item NNS cord-335975-m6lkrehi 2035 13 developed develop VBN cord-335975-m6lkrehi 2035 14 by by IN cord-335975-m6lkrehi 2035 15 a a DT cord-335975-m6lkrehi 2035 16 sociologist sociologist NN cord-335975-m6lkrehi 2035 17 from from IN cord-335975-m6lkrehi 2035 18 semi semi JJ cord-335975-m6lkrehi 2035 19 - - JJ cord-335975-m6lkrehi 2035 20 directive directive JJ cord-335975-m6lkrehi 2035 21 interviews interview NNS cord-335975-m6lkrehi 2035 22 with with IN cord-335975-m6lkrehi 2035 23 clinicians clinician NNS cord-335975-m6lkrehi 2035 24 . . . cord-335975-m6lkrehi 2036 1 Results result NNS cord-335975-m6lkrehi 2036 2 : : : cord-335975-m6lkrehi 2037 1 Among among IN cord-335975-m6lkrehi 2037 2 857 857 CD cord-335975-m6lkrehi 2037 3 patients patient NNS cord-335975-m6lkrehi 2037 4 discharged discharge VBN cord-335975-m6lkrehi 2037 5 from from IN cord-335975-m6lkrehi 2037 6 the the DT cord-335975-m6lkrehi 2037 7 ICU ICU NNP cord-335975-m6lkrehi 2037 8 alive alive JJ cord-335975-m6lkrehi 2037 9 , , , cord-335975-m6lkrehi 2037 10 a a DT cord-335975-m6lkrehi 2037 11 decision decision NN cord-335975-m6lkrehi 2037 12 not not RB cord-335975-m6lkrehi 2037 13 to to TO cord-335975-m6lkrehi 2037 14 re re VB cord-335975-m6lkrehi 2037 15 - - VB cord-335975-m6lkrehi 2037 16 admit admit JJ cord-335975-m6lkrehi 2037 17 to to IN cord-335975-m6lkrehi 2037 18 the the DT cord-335975-m6lkrehi 2037 19 ICU ICU NNP cord-335975-m6lkrehi 2037 20 during during IN cord-335975-m6lkrehi 2037 21 a a DT cord-335975-m6lkrehi 2037 22 same same JJ cord-335975-m6lkrehi 2037 23 hospital hospital NN cord-335975-m6lkrehi 2037 24 stay stay NN cord-335975-m6lkrehi 2037 25 was be VBD cord-335975-m6lkrehi 2037 26 noted note VBN cord-335975-m6lkrehi 2037 27 in in IN cord-335975-m6lkrehi 2037 28 the the DT cord-335975-m6lkrehi 2037 29 medical medical JJ cord-335975-m6lkrehi 2037 30 file file NN cord-335975-m6lkrehi 2037 31 of of IN cord-335975-m6lkrehi 2037 32 63 63 CD cord-335975-m6lkrehi 2037 33 patients patient NNS cord-335975-m6lkrehi 2037 34 ( ( -LRB- cord-335975-m6lkrehi 2037 35 7.3 7.3 CD cord-335975-m6lkrehi 2037 36 % % NN cord-335975-m6lkrehi 2037 37 ) ) -RRB- cord-335975-m6lkrehi 2037 38 . . . cord-335975-m6lkrehi 2038 1 This this DT cord-335975-m6lkrehi 2038 2 decision decision NN cord-335975-m6lkrehi 2038 3 was be VBD cord-335975-m6lkrehi 2038 4 primarily primarily RB cord-335975-m6lkrehi 2038 5 made make VBN cord-335975-m6lkrehi 2038 6 on on IN cord-335975-m6lkrehi 2038 7 the the DT cord-335975-m6lkrehi 2038 8 day day NN cord-335975-m6lkrehi 2038 9 of of IN cord-335975-m6lkrehi 2038 10 discharge discharge NN cord-335975-m6lkrehi 2038 11 ( ( -LRB- cord-335975-m6lkrehi 2038 12 42.6 42.6 CD cord-335975-m6lkrehi 2038 13 % % NN cord-335975-m6lkrehi 2038 14 ) ) -RRB- cord-335975-m6lkrehi 2038 15 , , , cord-335975-m6lkrehi 2038 16 and and CC cord-335975-m6lkrehi 2038 17 those those DT cord-335975-m6lkrehi 2038 18 involved involve VBN cord-335975-m6lkrehi 2038 19 in in IN cord-335975-m6lkrehi 2038 20 the the DT cord-335975-m6lkrehi 2038 21 decision decision NN cord-335975-m6lkrehi 2038 22 included include VBN cord-335975-m6lkrehi 2038 23 - - : cord-335975-m6lkrehi 2038 24 the the DT cord-335975-m6lkrehi 2038 25 family family NN cord-335975-m6lkrehi 2038 26 , , , cord-335975-m6lkrehi 2038 27 an an DT cord-335975-m6lkrehi 2038 28 outside outside JJ cord-335975-m6lkrehi 2038 29 consultant consultant NN cord-335975-m6lkrehi 2038 30 , , , cord-335975-m6lkrehi 2038 31 and and CC cord-335975-m6lkrehi 2038 32 the the DT cord-335975-m6lkrehi 2038 33 patient patient NN cord-335975-m6lkrehi 2038 34 themselves -PRON- PRP cord-335975-m6lkrehi 2038 35 in in IN cord-335975-m6lkrehi 2038 36 54 54 CD cord-335975-m6lkrehi 2038 37 , , , cord-335975-m6lkrehi 2038 38 31.7 31.7 CD cord-335975-m6lkrehi 2038 39 and and CC cord-335975-m6lkrehi 2038 40 15.9 15.9 CD cord-335975-m6lkrehi 2038 41 % % NN cord-335975-m6lkrehi 2038 42 of of IN cord-335975-m6lkrehi 2038 43 cases case NNS cord-335975-m6lkrehi 2038 44 respectively respectively RB cord-335975-m6lkrehi 2038 45 . . . cord-335975-m6lkrehi 2039 1 The the DT cord-335975-m6lkrehi 2039 2 decision decision NN cord-335975-m6lkrehi 2039 3 was be VBD cord-335975-m6lkrehi 2039 4 justified justify VBN cord-335975-m6lkrehi 2039 5 in in IN cord-335975-m6lkrehi 2039 6 medical medical JJ cord-335975-m6lkrehi 2039 7 terms term NNS cord-335975-m6lkrehi 2039 8 in in IN cord-335975-m6lkrehi 2039 9 92.1 92.1 CD cord-335975-m6lkrehi 2039 10 % % NN cord-335975-m6lkrehi 2039 11 of of IN cord-335975-m6lkrehi 2039 12 cases case NNS cord-335975-m6lkrehi 2039 13 , , , cord-335975-m6lkrehi 2039 14 and and CC cord-335975-m6lkrehi 2039 15 the the DT cord-335975-m6lkrehi 2039 16 main main JJ cord-335975-m6lkrehi 2039 17 reasons reason NNS cord-335975-m6lkrehi 2039 18 cited cite VBD cord-335975-m6lkrehi 2039 19 were-(1 were-(1 CD cord-335975-m6lkrehi 2039 20 ) ) -RRB- cord-335975-m6lkrehi 2039 21 therapeutic therapeutic JJ cord-335975-m6lkrehi 2039 22 impasse impasse NN cord-335975-m6lkrehi 2039 23 ( ( -LRB- cord-335975-m6lkrehi 2039 24 52.4 52.4 CD cord-335975-m6lkrehi 2039 25 % % NN cord-335975-m6lkrehi 2039 26 ) ) -RRB- cord-335975-m6lkrehi 2039 27 + + NN cord-335975-m6lkrehi 2039 28 ( ( -LRB- cord-335975-m6lkrehi 2039 29 2 2 LS cord-335975-m6lkrehi 2039 30 ) ) -RRB- cord-335975-m6lkrehi 2039 31 comorbidities comorbiditie NNS cord-335975-m6lkrehi 2039 32 ( ( -LRB- cord-335975-m6lkrehi 2039 33 44.4 44.4 CD cord-335975-m6lkrehi 2039 34 % % NN cord-335975-m6lkrehi 2039 35 ) ) -RRB- cord-335975-m6lkrehi 2039 36 + + NN cord-335975-m6lkrehi 2039 37 ( ( -LRB- cord-335975-m6lkrehi 2039 38 3 3 CD cord-335975-m6lkrehi 2039 39 ) ) -RRB- cord-335975-m6lkrehi 2039 40 degree degree NN cord-335975-m6lkrehi 2039 41 of of IN cord-335975-m6lkrehi 2039 42 dependence dependence NN cord-335975-m6lkrehi 2039 43 of of IN cord-335975-m6lkrehi 2039 44 the the DT cord-335975-m6lkrehi 2039 45 patient patient NN cord-335975-m6lkrehi 2039 46 ( ( -LRB- cord-335975-m6lkrehi 2039 47 34.9 34.9 CD cord-335975-m6lkrehi 2039 48 % % NN cord-335975-m6lkrehi 2039 49 ) ) -RRB- cord-335975-m6lkrehi 2039 50 . . . cord-335975-m6lkrehi 2040 1 Patients patient NNS cord-335975-m6lkrehi 2040 2 concerned concern VBN cord-335975-m6lkrehi 2040 3 by by IN cord-335975-m6lkrehi 2040 4 decisions decision NNS cord-335975-m6lkrehi 2040 5 of of IN cord-335975-m6lkrehi 2040 6 this this DT cord-335975-m6lkrehi 2040 7 type type NN cord-335975-m6lkrehi 2040 8 were be VBD cord-335975-m6lkrehi 2040 9 generally generally RB cord-335975-m6lkrehi 2040 10 older old JJR cord-335975-m6lkrehi 2040 11 ( ( -LRB- cord-335975-m6lkrehi 2040 12 75 75 CD cord-335975-m6lkrehi 2040 13 vs vs IN cord-335975-m6lkrehi 2040 14 65.6 65.6 CD cord-335975-m6lkrehi 2040 15 years year NNS cord-335975-m6lkrehi 2040 16 , , , cord-335975-m6lkrehi 2040 17 p p NN cord-335975-m6lkrehi 2040 18 < < XX cord-335975-m6lkrehi 2040 19 0.0001 0.0001 CD cord-335975-m6lkrehi 2040 20 ) ) -RRB- cord-335975-m6lkrehi 2040 21 , , , cord-335975-m6lkrehi 2040 22 with with IN cord-335975-m6lkrehi 2040 23 more more JJR cord-335975-m6lkrehi 2040 24 comorbidities comorbiditie NNS cord-335975-m6lkrehi 2040 25 ( ( -LRB- cord-335975-m6lkrehi 2040 26 median median NN cord-335975-m6lkrehi 2040 27 4 4 CD cord-335975-m6lkrehi 2040 28 vs vs IN cord-335975-m6lkrehi 2040 29 2 2 CD cord-335975-m6lkrehi 2040 30 , , , cord-335975-m6lkrehi 2040 31 p p NN cord-335975-m6lkrehi 2040 32 = = SYM cord-335975-m6lkrehi 2040 33 0.001 0.001 CD cord-335975-m6lkrehi 2040 34 ) ) -RRB- cord-335975-m6lkrehi 2040 35 , , , cord-335975-m6lkrehi 2040 36 greater great JJR cord-335975-m6lkrehi 2040 37 loss loss NN cord-335975-m6lkrehi 2040 38 of of IN cord-335975-m6lkrehi 2040 39 dependence dependence NN cord-335975-m6lkrehi 2040 40 according accord VBG cord-335975-m6lkrehi 2040 41 to to IN cord-335975-m6lkrehi 2040 42 Katz Katz NNP cord-335975-m6lkrehi 2040 43 's 's POS cord-335975-m6lkrehi 2040 44 activities activity NNS cord-335975-m6lkrehi 2040 45 of of IN cord-335975-m6lkrehi 2040 46 daily daily JJ cord-335975-m6lkrehi 2040 47 living living NN cord-335975-m6lkrehi 2040 48 ( ( -LRB- cord-335975-m6lkrehi 2040 49 5 5 CD cord-335975-m6lkrehi 2040 50 vs vs IN cord-335975-m6lkrehi 2040 51 6 6 CD cord-335975-m6lkrehi 2040 52 , , , cord-335975-m6lkrehi 2040 53 p p NN cord-335975-m6lkrehi 2040 54 < < XX cord-335975-m6lkrehi 2040 55 0.0001 0.0001 CD cord-335975-m6lkrehi 2040 56 ) ) -RRB- cord-335975-m6lkrehi 2040 57 , , , cord-335975-m6lkrehi 2040 58 and and CC cord-335975-m6lkrehi 2040 59 longer long JJR cord-335975-m6lkrehi 2040 60 duration duration NN cord-335975-m6lkrehi 2040 61 of of IN cord-335975-m6lkrehi 2040 62 life life NN cord-335975-m6lkrehi 2040 63 - - HYPH cord-335975-m6lkrehi 2040 64 sustaining sustain VBG cord-335975-m6lkrehi 2040 65 therapies therapy NNS cord-335975-m6lkrehi 2040 66 ( ( -LRB- cord-335975-m6lkrehi 2040 67 7.5 7.5 CD cord-335975-m6lkrehi 2040 68 vs vs IN cord-335975-m6lkrehi 2040 69 5 5 CD cord-335975-m6lkrehi 2040 70 days day NNS cord-335975-m6lkrehi 2040 71 , , , cord-335975-m6lkrehi 2040 72 p p NN cord-335975-m6lkrehi 2040 73 = = SYM cord-335975-m6lkrehi 2040 74 0.028 0.028 CD cord-335975-m6lkrehi 2040 75 ) ) -RRB- cord-335975-m6lkrehi 2040 76 . . . cord-335975-m6lkrehi 2041 1 Conclusion conclusion NN cord-335975-m6lkrehi 2041 2 : : : cord-335975-m6lkrehi 2042 1 Although although IN cord-335975-m6lkrehi 2042 2 the the DT cord-335975-m6lkrehi 2042 3 profile profile NN cord-335975-m6lkrehi 2042 4 of of IN cord-335975-m6lkrehi 2042 5 the the DT cord-335975-m6lkrehi 2042 6 patients patient NNS cord-335975-m6lkrehi 2042 7 identified identify VBN cord-335975-m6lkrehi 2042 8 in in IN cord-335975-m6lkrehi 2042 9 this this DT cord-335975-m6lkrehi 2042 10 study study NN cord-335975-m6lkrehi 2042 11 likely likely RB cord-335975-m6lkrehi 2042 12 justified justify VBD cord-335975-m6lkrehi 2042 13 the the DT cord-335975-m6lkrehi 2042 14 decision decision NN cord-335975-m6lkrehi 2042 15 not not RB cord-335975-m6lkrehi 2042 16 to to TO cord-335975-m6lkrehi 2042 17 re re VB cord-335975-m6lkrehi 2042 18 - - VB cord-335975-m6lkrehi 2042 19 admit admit VB cord-335975-m6lkrehi 2042 20 the the DT cord-335975-m6lkrehi 2042 21 patient patient NN cord-335975-m6lkrehi 2042 22 to to IN cord-335975-m6lkrehi 2042 23 the the DT cord-335975-m6lkrehi 2042 24 ICU ICU NNP cord-335975-m6lkrehi 2042 25 , , , cord-335975-m6lkrehi 2042 26 there there EX cord-335975-m6lkrehi 2042 27 is be VBZ cord-335975-m6lkrehi 2042 28 room room NN cord-335975-m6lkrehi 2042 29 for for IN cord-335975-m6lkrehi 2042 30 improvement improvement NN cord-335975-m6lkrehi 2042 31 in in IN cord-335975-m6lkrehi 2042 32 the the DT cord-335975-m6lkrehi 2042 33 decision decision NN cord-335975-m6lkrehi 2042 34 - - HYPH cord-335975-m6lkrehi 2042 35 making make VBG cord-335975-m6lkrehi 2042 36 process process NN cord-335975-m6lkrehi 2042 37 . . . cord-335975-m6lkrehi 2043 1 Introduction introduction NN cord-335975-m6lkrehi 2043 2 : : : cord-335975-m6lkrehi 2043 3 Most Most JJS cord-335975-m6lkrehi 2043 4 of of IN cord-335975-m6lkrehi 2043 5 organ organ NN cord-335975-m6lkrehi 2043 6 donors donor NNS cord-335975-m6lkrehi 2043 7 are be VBP cord-335975-m6lkrehi 2043 8 brain brain NN cord-335975-m6lkrehi 2043 9 dead dead JJ cord-335975-m6lkrehi 2043 10 patients patient NNS cord-335975-m6lkrehi 2043 11 . . . cord-335975-m6lkrehi 2044 1 In in IN cord-335975-m6lkrehi 2044 2 some some DT cord-335975-m6lkrehi 2044 3 cases case NNS cord-335975-m6lkrehi 2044 4 , , , cord-335975-m6lkrehi 2044 5 patients patient NNS cord-335975-m6lkrehi 2044 6 are be VBP cord-335975-m6lkrehi 2044 7 identified identify VBN cord-335975-m6lkrehi 2044 8 as as IN cord-335975-m6lkrehi 2044 9 potential potential JJ cord-335975-m6lkrehi 2044 10 donors donor NNS cord-335975-m6lkrehi 2044 11 before before IN cord-335975-m6lkrehi 2044 12 brain brain NN cord-335975-m6lkrehi 2044 13 death death NN cord-335975-m6lkrehi 2044 14 and and CC cord-335975-m6lkrehi 2044 15 will will MD cord-335975-m6lkrehi 2044 16 undergo undergo VB cord-335975-m6lkrehi 2044 17 intubation intubation NN cord-335975-m6lkrehi 2044 18 and and CC cord-335975-m6lkrehi 2044 19 mechanical mechanical JJ cord-335975-m6lkrehi 2044 20 ventilation ventilation NN cord-335975-m6lkrehi 2044 21 for for IN cord-335975-m6lkrehi 2044 22 the the DT cord-335975-m6lkrehi 2044 23 sole sole JJ cord-335975-m6lkrehi 2044 24 purpose purpose NN cord-335975-m6lkrehi 2044 25 of of IN cord-335975-m6lkrehi 2044 26 awaiting await VBG cord-335975-m6lkrehi 2044 27 brain brain NN cord-335975-m6lkrehi 2044 28 death death NN cord-335975-m6lkrehi 2044 29 . . . cord-335975-m6lkrehi 2045 1 The the DT cord-335975-m6lkrehi 2045 2 aim aim NN cord-335975-m6lkrehi 2045 3 of of IN cord-335975-m6lkrehi 2045 4 this this DT cord-335975-m6lkrehi 2045 5 study study NN cord-335975-m6lkrehi 2045 6 is be VBZ cord-335975-m6lkrehi 2045 7 to to TO cord-335975-m6lkrehi 2045 8 evaluate evaluate VB cord-335975-m6lkrehi 2045 9 the the DT cord-335975-m6lkrehi 2045 10 practices practice NNS cord-335975-m6lkrehi 2045 11 of of IN cord-335975-m6lkrehi 2045 12 professionals professional NNS cord-335975-m6lkrehi 2045 13 in in IN cord-335975-m6lkrehi 2045 14 charge charge NN cord-335975-m6lkrehi 2045 15 of of IN cord-335975-m6lkrehi 2045 16 potential potential JJ cord-335975-m6lkrehi 2045 17 donors donor NNS cord-335975-m6lkrehi 2045 18 . . . cord-335975-m6lkrehi 2046 1 ( ( -LRB- cord-335975-m6lkrehi 2046 2 Table table NN cord-335975-m6lkrehi 2046 3 1 1 CD cord-335975-m6lkrehi 2046 4 ) ) -RRB- cord-335975-m6lkrehi 2046 5 . . . cord-335975-m6lkrehi 2047 1 In in IN cord-335975-m6lkrehi 2047 2 this this DT cord-335975-m6lkrehi 2047 3 case case NN cord-335975-m6lkrehi 2047 4 , , , cord-335975-m6lkrehi 2047 5 the the DT cord-335975-m6lkrehi 2047 6 issue issue NN cord-335975-m6lkrehi 2047 7 of of IN cord-335975-m6lkrehi 2047 8 organ organ NN cord-335975-m6lkrehi 2047 9 donation donation NN cord-335975-m6lkrehi 2047 10 was be VBD cord-335975-m6lkrehi 2047 11 addressed address VBN cord-335975-m6lkrehi 2047 12 to to IN cord-335975-m6lkrehi 2047 13 the the DT cord-335975-m6lkrehi 2047 14 relatives relative NNS cord-335975-m6lkrehi 2047 15 before before IN cord-335975-m6lkrehi 2047 16 intubation intubation NN cord-335975-m6lkrehi 2047 17 by by IN cord-335975-m6lkrehi 2047 18 42 42 CD cord-335975-m6lkrehi 2047 19 % % NN cord-335975-m6lkrehi 2047 20 of of IN cord-335975-m6lkrehi 2047 21 ICUp ICUp NNS cord-335975-m6lkrehi 2047 22 and and CC cord-335975-m6lkrehi 2047 23 68 68 CD cord-335975-m6lkrehi 2047 24 % % NN cord-335975-m6lkrehi 2047 25 of of IN cord-335975-m6lkrehi 2047 26 non non JJ cord-335975-m6lkrehi 2047 27 ICUp ICUp NNS cord-335975-m6lkrehi 2047 28 ( ( -LRB- cord-335975-m6lkrehi 2047 29 p p NN cord-335975-m6lkrehi 2047 30 = = SYM cord-335975-m6lkrehi 2047 31 0.03 0.03 CD cord-335975-m6lkrehi 2047 32 ) ) -RRB- cord-335975-m6lkrehi 2047 33 . . . cord-335975-m6lkrehi 2048 1 29 29 CD cord-335975-m6lkrehi 2048 2 % % NN cord-335975-m6lkrehi 2048 3 of of IN cord-335975-m6lkrehi 2048 4 participants participant NNS cord-335975-m6lkrehi 2048 5 never never RB cord-335975-m6lkrehi 2048 6 addressed address VBD cord-335975-m6lkrehi 2048 7 organ organ NN cord-335975-m6lkrehi 2048 8 donation donation NN cord-335975-m6lkrehi 2048 9 before before IN cord-335975-m6lkrehi 2048 10 the the DT cord-335975-m6lkrehi 2048 11 brain brain NN cord-335975-m6lkrehi 2048 12 death death NN cord-335975-m6lkrehi 2048 13 . . . cord-335975-m6lkrehi 2049 1 For for IN cord-335975-m6lkrehi 2049 2 the the DT cord-335975-m6lkrehi 2049 3 71 71 CD cord-335975-m6lkrehi 2049 4 % % NN cord-335975-m6lkrehi 2049 5 who who WP cord-335975-m6lkrehi 2049 6 have have VBP cord-335975-m6lkrehi 2049 7 done do VBN cord-335975-m6lkrehi 2049 8 so so RB cord-335975-m6lkrehi 2049 9 at at IN cord-335975-m6lkrehi 2049 10 least least JJS cord-335975-m6lkrehi 2049 11 once once RB cord-335975-m6lkrehi 2049 12 , , , cord-335975-m6lkrehi 2049 13 organ organ NN cord-335975-m6lkrehi 2049 14 harvesting harvesting NN cord-335975-m6lkrehi 2049 15 never never RB cord-335975-m6lkrehi 2049 16 happened happen VBD cord-335975-m6lkrehi 2049 17 in in IN cord-335975-m6lkrehi 2049 18 20 20 CD cord-335975-m6lkrehi 2049 19 % % NN cord-335975-m6lkrehi 2049 20 of of IN cord-335975-m6lkrehi 2049 21 cases case NNS cord-335975-m6lkrehi 2049 22 . . . cord-335975-m6lkrehi 2050 1 Legitimacy legitimacy NN cord-335975-m6lkrehi 2050 2 and and CC cord-335975-m6lkrehi 2050 3 difficulties difficulty NNS cord-335975-m6lkrehi 2050 4 ( ( -LRB- cord-335975-m6lkrehi 2050 5 Table table NN cord-335975-m6lkrehi 2050 6 1 1 CD cord-335975-m6lkrehi 2050 7 ) ) -RRB- cord-335975-m6lkrehi 2050 8 -21 -21 : cord-335975-m6lkrehi 2050 9 % % NN cord-335975-m6lkrehi 2050 10 of of IN cord-335975-m6lkrehi 2050 11 respondents respondent NNS cord-335975-m6lkrehi 2050 12 felt feel VBD cord-335975-m6lkrehi 2050 13 that that IN cord-335975-m6lkrehi 2050 14 when when WRB cord-335975-m6lkrehi 2050 15 a a DT cord-335975-m6lkrehi 2050 16 decision decision NN cord-335975-m6lkrehi 2050 17 of of IN cord-335975-m6lkrehi 2050 18 treatment treatment NN cord-335975-m6lkrehi 2050 19 withdrawal withdrawal NN cord-335975-m6lkrehi 2050 20 or or CC cord-335975-m6lkrehi 2050 21 withholding withholding NN cord-335975-m6lkrehi 2050 22 is be VBZ cord-335975-m6lkrehi 2050 23 taken take VBN cord-335975-m6lkrehi 2050 24 , , , cord-335975-m6lkrehi 2050 25 the the DT cord-335975-m6lkrehi 2050 26 patient patient NN cord-335975-m6lkrehi 2050 27 should should MD cord-335975-m6lkrehi 2050 28 not not RB cord-335975-m6lkrehi 2050 29 go go VB cord-335975-m6lkrehi 2050 30 to to IN cord-335975-m6lkrehi 2050 31 ICU ICU NNP cord-335975-m6lkrehi 2050 32 for for IN cord-335975-m6lkrehi 2050 33 any any DT cord-335975-m6lkrehi 2050 34 reason reason NN cord-335975-m6lkrehi 2050 35 and and CC cord-335975-m6lkrehi 2050 36 29 29 CD cord-335975-m6lkrehi 2050 37 % % NN cord-335975-m6lkrehi 2050 38 think think VBP cord-335975-m6lkrehi 2050 39 that that IN cord-335975-m6lkrehi 2050 40 these these DT cord-335975-m6lkrehi 2050 41 patients patient NNS cord-335975-m6lkrehi 2050 42 should should MD cord-335975-m6lkrehi 2050 43 be be VB cord-335975-m6lkrehi 2050 44 allowed allow VBN cord-335975-m6lkrehi 2050 45 to to TO cord-335975-m6lkrehi 2050 46 die die VB cord-335975-m6lkrehi 2050 47 " " `` cord-335975-m6lkrehi 2050 48 quietly quietly RB cord-335975-m6lkrehi 2050 49 " " '' cord-335975-m6lkrehi 2050 50 . . . cord-335975-m6lkrehi 2051 1 The the DT cord-335975-m6lkrehi 2051 2 prospect prospect NN cord-335975-m6lkrehi 2051 3 of of IN cord-335975-m6lkrehi 2051 4 an an DT cord-335975-m6lkrehi 2051 5 extubation extubation NN cord-335975-m6lkrehi 2051 6 if if IN cord-335975-m6lkrehi 2051 7 brain brain NN cord-335975-m6lkrehi 2051 8 death death NN cord-335975-m6lkrehi 2051 9 does do VBZ cord-335975-m6lkrehi 2051 10 not not RB cord-335975-m6lkrehi 2051 11 occur occur VB cord-335975-m6lkrehi 2051 12 or or CC cord-335975-m6lkrehi 2051 13 in in IN cord-335975-m6lkrehi 2051 14 case case NN cord-335975-m6lkrehi 2051 15 of of IN cord-335975-m6lkrehi 2051 16 organ organ NN cord-335975-m6lkrehi 2051 17 donation donation NN cord-335975-m6lkrehi 2051 18 refusal refusal NN cord-335975-m6lkrehi 2051 19 is be VBZ cord-335975-m6lkrehi 2051 20 a a DT cord-335975-m6lkrehi 2051 21 problem problem NN cord-335975-m6lkrehi 2051 22 for for IN cord-335975-m6lkrehi 2051 23 24 24 CD cord-335975-m6lkrehi 2051 24 % % NN cord-335975-m6lkrehi 2051 25 of of IN cord-335975-m6lkrehi 2051 26 ICUp ICUp NNS cord-335975-m6lkrehi 2051 27 and and CC cord-335975-m6lkrehi 2051 28 38 38 CD cord-335975-m6lkrehi 2051 29 % % NN cord-335975-m6lkrehi 2051 30 of of IN cord-335975-m6lkrehi 2051 31 non non JJ cord-335975-m6lkrehi 2051 32 ICUp ICUp NNS cord-335975-m6lkrehi 2051 33 ( ( -LRB- cord-335975-m6lkrehi 2051 34 p p NN cord-335975-m6lkrehi 2051 35 = = SYM cord-335975-m6lkrehi 2051 36 0.08 0.08 CD cord-335975-m6lkrehi 2051 37 ) ) -RRB- cord-335975-m6lkrehi 2051 38 . . . cord-335975-m6lkrehi 2052 1 88 88 CD cord-335975-m6lkrehi 2052 2 % % NN cord-335975-m6lkrehi 2052 3 of of IN cord-335975-m6lkrehi 2052 4 ICUp ICUp NNS cord-335975-m6lkrehi 2052 5 and and CC cord-335975-m6lkrehi 2052 6 93 93 CD cord-335975-m6lkrehi 2052 7 % % NN cord-335975-m6lkrehi 2052 8 of of IN cord-335975-m6lkrehi 2052 9 non non JJ cord-335975-m6lkrehi 2052 10 ICUp ICUp NNS cord-335975-m6lkrehi 2052 11 think think VBP cord-335975-m6lkrehi 2052 12 they -PRON- PRP cord-335975-m6lkrehi 2052 13 would would MD cord-335975-m6lkrehi 2052 14 need need VB cord-335975-m6lkrehi 2052 15 to to TO cord-335975-m6lkrehi 2052 16 receive receive VB cord-335975-m6lkrehi 2052 17 training training NN cord-335975-m6lkrehi 2052 18 . . . cord-335975-m6lkrehi 2053 1 Conclusion conclusion NN cord-335975-m6lkrehi 2053 2 : : : cord-335975-m6lkrehi 2054 1 This this DT cord-335975-m6lkrehi 2054 2 study study NN cord-335975-m6lkrehi 2054 3 shows show VBZ cord-335975-m6lkrehi 2054 4 that that IN cord-335975-m6lkrehi 2054 5 pursuing pursue VBG cord-335975-m6lkrehi 2054 6 mechanical mechanical JJ cord-335975-m6lkrehi 2054 7 ventilation ventilation NN cord-335975-m6lkrehi 2054 8 for for IN cord-335975-m6lkrehi 2054 9 the the DT cord-335975-m6lkrehi 2054 10 sole sole JJ cord-335975-m6lkrehi 2054 11 purpose purpose NN cord-335975-m6lkrehi 2054 12 of of IN cord-335975-m6lkrehi 2054 13 awaiting await VBG cord-335975-m6lkrehi 2054 14 brain brain NN cord-335975-m6lkrehi 2054 15 death death NN cord-335975-m6lkrehi 2054 16 and and CC cord-335975-m6lkrehi 2054 17 organ organ NN cord-335975-m6lkrehi 2054 18 harvesting harvesting NN cord-335975-m6lkrehi 2054 19 is be VBZ cord-335975-m6lkrehi 2054 20 a a DT cord-335975-m6lkrehi 2054 21 common common JJ cord-335975-m6lkrehi 2054 22 practice practice NN cord-335975-m6lkrehi 2054 23 , , , cord-335975-m6lkrehi 2054 24 and and CC cord-335975-m6lkrehi 2054 25 that that IN cord-335975-m6lkrehi 2054 26 intubating intubate VBG cord-335975-m6lkrehi 2054 27 a a DT cord-335975-m6lkrehi 2054 28 patient patient NN cord-335975-m6lkrehi 2054 29 for for IN cord-335975-m6lkrehi 2054 30 this this DT cord-335975-m6lkrehi 2054 31 purpose purpose NN cord-335975-m6lkrehi 2054 32 alone alone RB cord-335975-m6lkrehi 2054 33 is be VBZ cord-335975-m6lkrehi 2054 34 done do VBN cord-335975-m6lkrehi 2054 35 in in IN cord-335975-m6lkrehi 2054 36 most most JJS cord-335975-m6lkrehi 2054 37 of of IN cord-335975-m6lkrehi 2054 38 cases case NNS cord-335975-m6lkrehi 2054 39 but but CC cord-335975-m6lkrehi 2054 40 could could MD cord-335975-m6lkrehi 2054 41 still still RB cord-335975-m6lkrehi 2054 42 be be VB cord-335975-m6lkrehi 2054 43 more more RBR cord-335975-m6lkrehi 2054 44 generalized generalized JJ cord-335975-m6lkrehi 2054 45 . . . cord-335975-m6lkrehi 2055 1 On on IN cord-335975-m6lkrehi 2055 2 the the DT cord-335975-m6lkrehi 2055 3 other other JJ cord-335975-m6lkrehi 2055 4 hand hand NN cord-335975-m6lkrehi 2055 5 , , , cord-335975-m6lkrehi 2055 6 information information NN cord-335975-m6lkrehi 2055 7 to to IN cord-335975-m6lkrehi 2055 8 the the DT cord-335975-m6lkrehi 2055 9 relatives relative NNS cord-335975-m6lkrehi 2055 10 should should MD cord-335975-m6lkrehi 2055 11 be be VB cord-335975-m6lkrehi 2055 12 improved improve VBN cord-335975-m6lkrehi 2055 13 . . . cord-335975-m6lkrehi 2056 1 1 1 LS cord-335975-m6lkrehi 2056 2 - - SYM cord-335975-m6lkrehi 2056 3 7.3 7.3 CD cord-335975-m6lkrehi 2056 4 ] ] -RRB- cord-335975-m6lkrehi 2056 5 . . . cord-335975-m6lkrehi 2057 1 The the DT cord-335975-m6lkrehi 2057 2 effect effect NN cord-335975-m6lkrehi 2057 3 of of IN cord-335975-m6lkrehi 2057 4 PP PP NNP cord-335975-m6lkrehi 2057 5 on on IN cord-335975-m6lkrehi 2057 6 the the DT cord-335975-m6lkrehi 2057 7 monitored monitor VBN cord-335975-m6lkrehi 2057 8 parameters parameter NNS cord-335975-m6lkrehi 2057 9 varies vary VBZ cord-335975-m6lkrehi 2057 10 significantly significantly RB cord-335975-m6lkrehi 2057 11 between between IN cord-335975-m6lkrehi 2057 12 each each DT cord-335975-m6lkrehi 2057 13 patient patient NN cord-335975-m6lkrehi 2057 14 but but CC cord-335975-m6lkrehi 2057 15 also also RB cord-335975-m6lkrehi 2057 16 between between IN cord-335975-m6lkrehi 2057 17 each each DT cord-335975-m6lkrehi 2057 18 session session NN cord-335975-m6lkrehi 2057 19 for for IN cord-335975-m6lkrehi 2057 20 the the DT cord-335975-m6lkrehi 2057 21 same same JJ cord-335975-m6lkrehi 2057 22 patient patient NN cord-335975-m6lkrehi 2057 23 . . . cord-335975-m6lkrehi 2058 1 In in IN cord-335975-m6lkrehi 2058 2 positive positive JJ cord-335975-m6lkrehi 2058 3 responders responder NNS cord-335975-m6lkrehi 2058 4 , , , cord-335975-m6lkrehi 2058 5 the the DT cord-335975-m6lkrehi 2058 6 effect effect NN cord-335975-m6lkrehi 2058 7 continues continue VBZ cord-335975-m6lkrehi 2058 8 statistically statistically RB cord-335975-m6lkrehi 2058 9 for for IN cord-335975-m6lkrehi 2058 10 7 7 CD cord-335975-m6lkrehi 2058 11 to to TO cord-335975-m6lkrehi 2058 12 20 20 CD cord-335975-m6lkrehi 2058 13 h h NN cord-335975-m6lkrehi 2058 14 depending depend VBG cord-335975-m6lkrehi 2058 15 on on IN cord-335975-m6lkrehi 2058 16 the the DT cord-335975-m6lkrehi 2058 17 parameter parameter NN cord-335975-m6lkrehi 2058 18 studied-10.5 studied-10.5 NNP cord-335975-m6lkrehi 2058 19 h h NNP cord-335975-m6lkrehi 2058 20 for for IN cord-335975-m6lkrehi 2058 21 Vd Vd NNP cord-335975-m6lkrehi 2058 22 Vt Vt NNP cord-335975-m6lkrehi 2058 23 , , , cord-335975-m6lkrehi 2058 24 19.5 19.5 CD cord-335975-m6lkrehi 2058 25 for for IN cord-335975-m6lkrehi 2058 26 Phase phase NN cord-335975-m6lkrehi 2058 27 3 3 CD cord-335975-m6lkrehi 2058 28 slope slope NN cord-335975-m6lkrehi 2058 29 , , , cord-335975-m6lkrehi 2058 30 7 7 CD cord-335975-m6lkrehi 2058 31 for for IN cord-335975-m6lkrehi 2058 32 PetCO2 petco2 CD cord-335975-m6lkrehi 2058 33 and and CC cord-335975-m6lkrehi 2058 34 9 9 CD cord-335975-m6lkrehi 2058 35 for for IN cord-335975-m6lkrehi 2058 36 Cdyn Cdyn NNP cord-335975-m6lkrehi 2058 37 . . . cord-335975-m6lkrehi 2059 1 The the DT cord-335975-m6lkrehi 2059 2 maximum maximum JJ cord-335975-m6lkrehi 2059 3 effect effect NN cord-335975-m6lkrehi 2059 4 of of IN cord-335975-m6lkrehi 2059 5 prone prone JJ cord-335975-m6lkrehi 2059 6 positioning positioning NN cord-335975-m6lkrehi 2059 7 on on IN cord-335975-m6lkrehi 2059 8 selected select VBN cord-335975-m6lkrehi 2059 9 parameters parameter NNS cord-335975-m6lkrehi 2059 10 seems seem VBZ cord-335975-m6lkrehi 2059 11 to to TO cord-335975-m6lkrehi 2059 12 be be VB cord-335975-m6lkrehi 2059 13 obtained obtain VBN cord-335975-m6lkrehi 2059 14 after after IN cord-335975-m6lkrehi 2059 15 20 20 CD cord-335975-m6lkrehi 2059 16 h h NN cord-335975-m6lkrehi 2059 17 of of IN cord-335975-m6lkrehi 2059 18 therapy therapy NN cord-335975-m6lkrehi 2059 19 . . . cord-335975-m6lkrehi 2059 20 _SP cord-335975-m6lkrehi 2060 1 The the DT cord-335975-m6lkrehi 2060 2 acute acute JJ cord-335975-m6lkrehi 2060 3 respiratory respiratory JJ cord-335975-m6lkrehi 2060 4 distress distress NN cord-335975-m6lkrehi 2060 5 syndrome syndrome NN cord-335975-m6lkrehi 2060 6 ( ( -LRB- cord-335975-m6lkrehi 2060 7 ARDS ARDS NNP cord-335975-m6lkrehi 2060 8 ) ) -RRB- cord-335975-m6lkrehi 2060 9 is be VBZ cord-335975-m6lkrehi 2060 10 characterized characterize VBN cord-335975-m6lkrehi 2060 11 by by IN cord-335975-m6lkrehi 2060 12 lung lung NN cord-335975-m6lkrehi 2060 13 infiltration infiltration NN cord-335975-m6lkrehi 2060 14 with with IN cord-335975-m6lkrehi 2060 15 activated activate VBN cord-335975-m6lkrehi 2060 16 neutrophils neutrophil NNS cord-335975-m6lkrehi 2060 17 . . . cord-335975-m6lkrehi 2061 1 Neutrophil Neutrophil NNP cord-335975-m6lkrehi 2061 2 extracellular extracellular JJ cord-335975-m6lkrehi 2061 3 traps trap NNS cord-335975-m6lkrehi 2061 4 ( ( -LRB- cord-335975-m6lkrehi 2061 5 NETs net NNS cord-335975-m6lkrehi 2061 6 ) ) -RRB- cord-335975-m6lkrehi 2061 7 are be VBP cord-335975-m6lkrehi 2061 8 antimicrobial antimicrobial JJ cord-335975-m6lkrehi 2061 9 structures structure NNS cord-335975-m6lkrehi 2061 10 released release VBN cord-335975-m6lkrehi 2061 11 by by IN cord-335975-m6lkrehi 2061 12 neutrophils neutrophil NNS cord-335975-m6lkrehi 2061 13 . . . cord-335975-m6lkrehi 2062 1 NETs net NNS cord-335975-m6lkrehi 2062 2 have have VBP cord-335975-m6lkrehi 2062 3 also also RB cord-335975-m6lkrehi 2062 4 been be VBN cord-335975-m6lkrehi 2062 5 associated associate VBN cord-335975-m6lkrehi 2062 6 with with IN cord-335975-m6lkrehi 2062 7 tissue tissue NN cord-335975-m6lkrehi 2062 8 damage damage NN cord-335975-m6lkrehi 2062 9 in in IN cord-335975-m6lkrehi 2062 10 experimental experimental JJ cord-335975-m6lkrehi 2062 11 models model NNS cord-335975-m6lkrehi 2062 12 of of IN cord-335975-m6lkrehi 2062 13 acute acute JJ cord-335975-m6lkrehi 2062 14 lung lung NN cord-335975-m6lkrehi 2062 15 injury injury NN cord-335975-m6lkrehi 2062 16 . . . cord-335975-m6lkrehi 2063 1 Whether whether IN cord-335975-m6lkrehi 2063 2 NETs net NNS cord-335975-m6lkrehi 2063 3 are be VBP cord-335975-m6lkrehi 2063 4 involved involve VBN cord-335975-m6lkrehi 2063 5 in in IN cord-335975-m6lkrehi 2063 6 the the DT cord-335975-m6lkrehi 2063 7 pathogenesis pathogenesis NN cord-335975-m6lkrehi 2063 8 of of IN cord-335975-m6lkrehi 2063 9 human human JJ cord-335975-m6lkrehi 2063 10 ARDS ARDS NNP cord-335975-m6lkrehi 2063 11 and and CC cord-335975-m6lkrehi 2063 12 could could MD cord-335975-m6lkrehi 2063 13 be be VB cord-335975-m6lkrehi 2063 14 a a DT cord-335975-m6lkrehi 2063 15 potential potential JJ cord-335975-m6lkrehi 2063 16 therapeutic therapeutic JJ cord-335975-m6lkrehi 2063 17 target target NN cord-335975-m6lkrehi 2063 18 is be VBZ cord-335975-m6lkrehi 2063 19 unknown unknown JJ cord-335975-m6lkrehi 2063 20 . . . cord-335975-m6lkrehi 2064 1 We -PRON- PRP cord-335975-m6lkrehi 2064 2 aimed aim VBD cord-335975-m6lkrehi 2064 3 to to TO cord-335975-m6lkrehi 2064 4 quantify quantify VB cord-335975-m6lkrehi 2064 5 alveolar alveolar JJ cord-335975-m6lkrehi 2064 6 NETs net NNS cord-335975-m6lkrehi 2064 7 production production NN cord-335975-m6lkrehi 2064 8 in in IN cord-335975-m6lkrehi 2064 9 patients patient NNS cord-335975-m6lkrehi 2064 10 with with IN cord-335975-m6lkrehi 2064 11 pneumonia pneumonia NN cord-335975-m6lkrehi 2064 12 and and CC cord-335975-m6lkrehi 2064 13 ARDS ARDS NNP cord-335975-m6lkrehi 2064 14 and and CC cord-335975-m6lkrehi 2064 15 assess assess VB cord-335975-m6lkrehi 2064 16 its -PRON- PRP$ cord-335975-m6lkrehi 2064 17 relationship relationship NN cord-335975-m6lkrehi 2064 18 with with IN cord-335975-m6lkrehi 2064 19 outcomes outcome NNS cord-335975-m6lkrehi 2064 20 . . . cord-335975-m6lkrehi 2065 1 Patients patient NNS cord-335975-m6lkrehi 2065 2 and and CC cord-335975-m6lkrehi 2065 3 methods method NNS cord-335975-m6lkrehi 2065 4 : : : cord-335975-m6lkrehi 2065 5 Prospective prospective JJ cord-335975-m6lkrehi 2065 6 monocentric monocentric JJ cord-335975-m6lkrehi 2065 7 study study NN cord-335975-m6lkrehi 2065 8 . . . cord-335975-m6lkrehi 2066 1 Patients patient NNS cord-335975-m6lkrehi 2066 2 admitted admit VBN cord-335975-m6lkrehi 2066 3 in in IN cord-335975-m6lkrehi 2066 4 the the DT cord-335975-m6lkrehi 2066 5 ICU ICU NNP cord-335975-m6lkrehi 2066 6 in in IN cord-335975-m6lkrehi 2066 7 2014 2014 CD cord-335975-m6lkrehi 2066 8 2015 2015 CD cord-335975-m6lkrehi 2066 9 with with IN cord-335975-m6lkrehi 2066 10 pneumonia pneumonia NN cord-335975-m6lkrehi 2066 11 and and CC cord-335975-m6lkrehi 2066 12 moderate moderate JJ cord-335975-m6lkrehi 2066 13 severe severe JJ cord-335975-m6lkrehi 2066 14 ARDS ARDS NNP cord-335975-m6lkrehi 2066 15 were be VBD cord-335975-m6lkrehi 2066 16 included include VBN cord-335975-m6lkrehi 2066 17 . . . cord-335975-m6lkrehi 2067 1 Immunosuppressed immunosuppressed JJ cord-335975-m6lkrehi 2067 2 patients patient NNS cord-335975-m6lkrehi 2067 3 were be VBD cord-335975-m6lkrehi 2067 4 excluded exclude VBN cord-335975-m6lkrehi 2067 5 . . . cord-335975-m6lkrehi 2068 1 NETs NETs NNP cord-335975-m6lkrehi 2068 2 ( ( -LRB- cord-335975-m6lkrehi 2068 3 DNAmyeloperoxidase DNAmyeloperoxidase NNP cord-335975-m6lkrehi 2068 4 ) ) -RRB- cord-335975-m6lkrehi 2068 5 levels level NNS cord-335975-m6lkrehi 2068 6 were be VBD cord-335975-m6lkrehi 2068 7 measured measure VBN cord-335975-m6lkrehi 2068 8 by by IN cord-335975-m6lkrehi 2068 9 ELISA ELISA NNP cord-335975-m6lkrehi 2068 10 in in IN cord-335975-m6lkrehi 2068 11 broncho broncho JJ cord-335975-m6lkrehi 2068 12 - - HYPH cord-335975-m6lkrehi 2068 13 alveolar alveolar NN cord-335975-m6lkrehi 2068 14 lavage lavage NN cord-335975-m6lkrehi 2068 15 ( ( -LRB- cord-335975-m6lkrehi 2068 16 BAL BAL NNP cord-335975-m6lkrehi 2068 17 ) ) -RRB- cord-335975-m6lkrehi 2068 18 fluid fluid NN cord-335975-m6lkrehi 2068 19 and and CC cord-335975-m6lkrehi 2068 20 serum serum NN cord-335975-m6lkrehi 2068 21 samples sample NNS cord-335975-m6lkrehi 2068 22 of of IN cord-335975-m6lkrehi 2068 23 ARDS ARDS NNP cord-335975-m6lkrehi 2068 24 patients patient NNS cord-335975-m6lkrehi 2068 25 and and CC cord-335975-m6lkrehi 2068 26 in in IN cord-335975-m6lkrehi 2068 27 those those DT cord-335975-m6lkrehi 2068 28 of of IN cord-335975-m6lkrehi 2068 29 control control NN cord-335975-m6lkrehi 2068 30 patients patient NNS cord-335975-m6lkrehi 2068 31 ( ( -LRB- cord-335975-m6lkrehi 2068 32 n n NN cord-335975-m6lkrehi 2068 33 = = SYM cord-335975-m6lkrehi 2068 34 4 4 CD cord-335975-m6lkrehi 2068 35 ) ) -RRB- cord-335975-m6lkrehi 2068 36 . . . cord-335975-m6lkrehi 2069 1 Patients patient NNS cord-335975-m6lkrehi 2069 2 with with IN cord-335975-m6lkrehi 2069 3 higher high JJR cord-335975-m6lkrehi 2069 4 and and CC cord-335975-m6lkrehi 2069 5 lower low JJR cord-335975-m6lkrehi 2069 6 BAL bal NN cord-335975-m6lkrehi 2069 7 fluid fluid NN cord-335975-m6lkrehi 2069 8 NETs nets NN cord-335975-m6lkrehi 2069 9 levels level NNS cord-335975-m6lkrehi 2069 10 were be VBD cord-335975-m6lkrehi 2069 11 compared compare VBN cord-335975-m6lkrehi 2069 12 using use VBG cord-335975-m6lkrehi 2069 13 the the DT cord-335975-m6lkrehi 2069 14 median median NN cord-335975-m6lkrehi 2069 15 as as IN cord-335975-m6lkrehi 2069 16 a a DT cord-335975-m6lkrehi 2069 17 cutoff cutoff NN cord-335975-m6lkrehi 2069 18 value value NN cord-335975-m6lkrehi 2069 19 . . . cord-335975-m6lkrehi 2070 1 Results result NNS cord-335975-m6lkrehi 2070 2 : : : cord-335975-m6lkrehi 2071 1 Thirty thirty CD cord-335975-m6lkrehi 2071 2 - - HYPH cord-335975-m6lkrehi 2071 3 five five CD cord-335975-m6lkrehi 2071 4 patients patient NNS cord-335975-m6lkrehi 2071 5 with with IN cord-335975-m6lkrehi 2071 6 bacterial bacterial JJ cord-335975-m6lkrehi 2071 7 ( ( -LRB- cord-335975-m6lkrehi 2071 8 n n NN cord-335975-m6lkrehi 2071 9 = = SYM cord-335975-m6lkrehi 2071 10 18 18 CD cord-335975-m6lkrehi 2071 11 ) ) -RRB- cord-335975-m6lkrehi 2071 12 , , , cord-335975-m6lkrehi 2071 13 viral viral JJ cord-335975-m6lkrehi 2071 14 ( ( -LRB- cord-335975-m6lkrehi 2071 15 n n NN cord-335975-m6lkrehi 2071 16 = = SYM cord-335975-m6lkrehi 2071 17 11 11 CD cord-335975-m6lkrehi 2071 18 ) ) -RRB- cord-335975-m6lkrehi 2071 19 or or CC cord-335975-m6lkrehi 2071 20 non non AFX cord-335975-m6lkrehi 2071 21 - - JJ cord-335975-m6lkrehi 2071 22 microbiologically microbiologically RB cord-335975-m6lkrehi 2071 23 documented document VBN cord-335975-m6lkrehi 2071 24 ( ( -LRB- cord-335975-m6lkrehi 2071 25 n n NN cord-335975-m6lkrehi 2071 26 = = SYM cord-335975-m6lkrehi 2071 27 6 6 CD cord-335975-m6lkrehi 2071 28 ) ) -RRB- cord-335975-m6lkrehi 2071 29 pneumonia pneumonia NN cord-335975-m6lkrehi 2071 30 and and CC cord-335975-m6lkrehi 2071 31 ARDS ARDS NNP cord-335975-m6lkrehi 2071 32 were be VBD cord-335975-m6lkrehi 2071 33 included include VBN cord-335975-m6lkrehi 2071 34 . . . cord-335975-m6lkrehi 2072 1 NETs net NNS cord-335975-m6lkrehi 2072 2 levels level NNS cord-335975-m6lkrehi 2072 3 were be VBD cord-335975-m6lkrehi 2072 4 significantly significantly RB cord-335975-m6lkrehi 2072 5 higher high JJR cord-335975-m6lkrehi 2072 6 in in IN cord-335975-m6lkrehi 2072 7 BAL bal NN cord-335975-m6lkrehi 2072 8 fluid fluid NN cord-335975-m6lkrehi 2072 9 than than IN cord-335975-m6lkrehi 2072 10 in in IN cord-335975-m6lkrehi 2072 11 blood blood NN cord-335975-m6lkrehi 2072 12 of of IN cord-335975-m6lkrehi 2072 13 ARDS ARDS NNP cord-335975-m6lkrehi 2072 14 but but CC cord-335975-m6lkrehi 2072 15 not not RB cord-335975-m6lkrehi 2072 16 of of IN cord-335975-m6lkrehi 2072 17 control control NN cord-335975-m6lkrehi 2072 18 patients patient NNS cord-335975-m6lkrehi 2073 1 ( ( -LRB- cord-335975-m6lkrehi 2073 2 Fig Fig NNP cord-335975-m6lkrehi 2073 3 . . . cord-335975-m6lkrehi 2073 4 1 1 CD cord-335975-m6lkrehi 2073 5 Introduction introduction NN cord-335975-m6lkrehi 2073 6 : : : cord-335975-m6lkrehi 2074 1 The the DT cord-335975-m6lkrehi 2074 2 ratio ratio NN cord-335975-m6lkrehi 2074 3 of of IN cord-335975-m6lkrehi 2074 4 arterial arterial JJ cord-335975-m6lkrehi 2074 5 oxygen oxygen NN cord-335975-m6lkrehi 2074 6 partial partial JJ cord-335975-m6lkrehi 2074 7 pressure pressure NN cord-335975-m6lkrehi 2074 8 to to IN cord-335975-m6lkrehi 2074 9 fractional fractional JJ cord-335975-m6lkrehi 2074 10 inspired inspire VBN cord-335975-m6lkrehi 2074 11 oxygen oxygen NN cord-335975-m6lkrehi 2074 12 ( ( -LRB- cord-335975-m6lkrehi 2074 13 PaO2 PaO2 NNS cord-335975-m6lkrehi 2074 14 FiO2 FiO2 NNS cord-335975-m6lkrehi 2074 15 or or CC cord-335975-m6lkrehi 2074 16 P P NNP cord-335975-m6lkrehi 2074 17 F F NNP cord-335975-m6lkrehi 2074 18 ) ) -RRB- cord-335975-m6lkrehi 2074 19 is be VBZ cord-335975-m6lkrehi 2074 20 daily daily RB cord-335975-m6lkrehi 2074 21 used use VBN cord-335975-m6lkrehi 2074 22 to to TO cord-335975-m6lkrehi 2074 23 assess assess VB cord-335975-m6lkrehi 2074 24 patients patient NNS cord-335975-m6lkrehi 2074 25 ' ' POS cord-335975-m6lkrehi 2074 26 evolution evolution NN cord-335975-m6lkrehi 2074 27 under under IN cord-335975-m6lkrehi 2074 28 ventilatory ventilatory JJ cord-335975-m6lkrehi 2074 29 support support NN cord-335975-m6lkrehi 2074 30 . . . cord-335975-m6lkrehi 2075 1 Some some DT cord-335975-m6lkrehi 2075 2 studies study NNS cord-335975-m6lkrehi 2075 3 reported report VBD cord-335975-m6lkrehi 2075 4 the the DT cord-335975-m6lkrehi 2075 5 reliability reliability NN cord-335975-m6lkrehi 2075 6 of of IN cord-335975-m6lkrehi 2075 7 percutaneous percutaneous JJ cord-335975-m6lkrehi 2075 8 oxygen oxygen NN cord-335975-m6lkrehi 2075 9 saturation saturation NN cord-335975-m6lkrehi 2075 10 ( ( -LRB- cord-335975-m6lkrehi 2075 11 SpO2 SpO2 NNS cord-335975-m6lkrehi 2075 12 ) ) -RRB- cord-335975-m6lkrehi 2075 13 to to TO cord-335975-m6lkrehi 2075 14 appreciate appreciate VB cord-335975-m6lkrehi 2075 15 PaO2 PaO2 NNS cord-335975-m6lkrehi 2075 16 easy easy JJ cord-335975-m6lkrehi 2075 17 to to TO cord-335975-m6lkrehi 2075 18 get get VB cord-335975-m6lkrehi 2075 19 on on IN cord-335975-m6lkrehi 2075 20 bedside bedside NN cord-335975-m6lkrehi 2075 21 . . . cord-335975-m6lkrehi 2076 1 Thus thus RB cord-335975-m6lkrehi 2076 2 two two CD cord-335975-m6lkrehi 2076 3 equations equation NNS cord-335975-m6lkrehi 2076 4 have have VBP cord-335975-m6lkrehi 2076 5 been be VBN cord-335975-m6lkrehi 2076 6 proposed propose VBN cord-335975-m6lkrehi 2076 7 - - : cord-335975-m6lkrehi 2076 8 Rice rice NN cord-335975-m6lkrehi 2076 9 equation equation NN cord-335975-m6lkrehi 2076 10 and and CC cord-335975-m6lkrehi 2076 11 Ellis Ellis NNP cord-335975-m6lkrehi 2076 12 equation equation NN cord-335975-m6lkrehi 2076 13 . . . cord-335975-m6lkrehi 2077 1 However however RB cord-335975-m6lkrehi 2077 2 , , , cord-335975-m6lkrehi 2077 3 no no DT cord-335975-m6lkrehi 2077 4 large large JJ cord-335975-m6lkrehi 2077 5 prospective prospective JJ cord-335975-m6lkrehi 2077 6 study study NN cord-335975-m6lkrehi 2077 7 assessed assess VBD cord-335975-m6lkrehi 2077 8 the the DT cord-335975-m6lkrehi 2077 9 reliability reliability NN cord-335975-m6lkrehi 2077 10 of of IN cord-335975-m6lkrehi 2077 11 such such JJ cord-335975-m6lkrehi 2077 12 equations equation NNS cord-335975-m6lkrehi 2077 13 to to TO cord-335975-m6lkrehi 2077 14 estimate estimate VB cord-335975-m6lkrehi 2077 15 the the DT cord-335975-m6lkrehi 2077 16 P p NN cord-335975-m6lkrehi 2077 17 F f NN cord-335975-m6lkrehi 2077 18 at at IN cord-335975-m6lkrehi 2077 19 the the DT cord-335975-m6lkrehi 2077 20 bedside bedside NN cord-335975-m6lkrehi 2077 21 in in IN cord-335975-m6lkrehi 2077 22 real real JJ cord-335975-m6lkrehi 2077 23 conditions condition NNS cord-335975-m6lkrehi 2077 24 . . . cord-335975-m6lkrehi 2078 1 Using use VBG cord-335975-m6lkrehi 2078 2 the the DT cord-335975-m6lkrehi 2078 3 SPECTRUM spectrum NN cord-335975-m6lkrehi 2079 1 ( ( -LRB- cord-335975-m6lkrehi 2079 2 Severe Severe NNP cord-335975-m6lkrehi 2079 3 hyPoxemia hypoxemia NN cord-335975-m6lkrehi 2079 4 - - HYPH cord-335975-m6lkrehi 2079 5 preva preva NN cord-335975-m6lkrehi 2079 6 - - HYPH cord-335975-m6lkrehi 2079 7 lEnCe lEnCe NNP cord-335975-m6lkrehi 2079 8 , , , cord-335975-m6lkrehi 2079 9 TReatment TReatment NNP cord-335975-m6lkrehi 2079 10 and and CC cord-335975-m6lkrehi 2079 11 oUtcoMe oUtcoMe NNP cord-335975-m6lkrehi 2079 12 ) ) -RRB- cord-335975-m6lkrehi 2079 13 study study VBP cord-335975-m6lkrehi 2079 14 , , , cord-335975-m6lkrehi 2079 15 we -PRON- PRP cord-335975-m6lkrehi 2079 16 aimed aim VBD cord-335975-m6lkrehi 2079 17 to to TO cord-335975-m6lkrehi 2079 18 evaluate evaluate VB cord-335975-m6lkrehi 2079 19 the the DT cord-335975-m6lkrehi 2079 20 reliability reliability NN cord-335975-m6lkrehi 2079 21 of of IN cord-335975-m6lkrehi 2079 22 SpO2 SpO2 NNS cord-335975-m6lkrehi 2079 23 obtained obtain VBN cord-335975-m6lkrehi 2079 24 by by IN cord-335975-m6lkrehi 2079 25 Rice Rice NNP cord-335975-m6lkrehi 2079 26 and and CC cord-335975-m6lkrehi 2079 27 Ellis Ellis NNP cord-335975-m6lkrehi 2079 28 equation equation NN cord-335975-m6lkrehi 2079 29 . . . cord-335975-m6lkrehi 2080 1 This this DT cord-335975-m6lkrehi 2080 2 study study NN cord-335975-m6lkrehi 2080 3 is be VBZ cord-335975-m6lkrehi 2080 4 a a DT cord-335975-m6lkrehi 2080 5 planned planned JJ cord-335975-m6lkrehi 2080 6 companion companion NN cord-335975-m6lkrehi 2080 7 of of IN cord-335975-m6lkrehi 2080 8 SPEC SPEC NNP cord-335975-m6lkrehi 2080 9 - - HYPH cord-335975-m6lkrehi 2080 10 TRUM TRUM NNP cord-335975-m6lkrehi 2080 11 study study NN cord-335975-m6lkrehi 2080 12 , , , cord-335975-m6lkrehi 2080 13 a a DT cord-335975-m6lkrehi 2080 14 recent recent JJ cord-335975-m6lkrehi 2080 15 prevalence prevalence NN cord-335975-m6lkrehi 2080 16 - - HYPH cord-335975-m6lkrehi 2080 17 point point NN cord-335975-m6lkrehi 2080 18 - - HYPH cord-335975-m6lkrehi 2080 19 day day NN cord-335975-m6lkrehi 2080 20 conducted conduct VBN cord-335975-m6lkrehi 2080 21 by by IN cord-335975-m6lkrehi 2080 22 the the DT cord-335975-m6lkrehi 2080 23 SRLF SRLF NNP cord-335975-m6lkrehi 2080 24 Trial Trial NNP cord-335975-m6lkrehi 2080 25 group group NN cord-335975-m6lkrehi 2080 26 in in IN cord-335975-m6lkrehi 2080 27 117 117 CD cord-335975-m6lkrehi 2080 28 french french NNP cord-335975-m6lkrehi 2080 29 - - HYPH cord-335975-m6lkrehi 2080 30 speaking speak VBG cord-335975-m6lkrehi 2080 31 ICU ICU NNP cord-335975-m6lkrehi 2080 32 aiming aim VBG cord-335975-m6lkrehi 2080 33 to to TO cord-335975-m6lkrehi 2080 34 report report VB cord-335975-m6lkrehi 2080 35 the the DT cord-335975-m6lkrehi 2080 36 patterns pattern NNS cord-335975-m6lkrehi 2080 37 and and CC cord-335975-m6lkrehi 2080 38 outcomes outcome NNS cord-335975-m6lkrehi 2080 39 of of IN cord-335975-m6lkrehi 2080 40 hypoxemic hypoxemic JJ cord-335975-m6lkrehi 2080 41 patients patient NNS cord-335975-m6lkrehi 2080 42 ( ( -LRB- cord-335975-m6lkrehi 2080 43 defined define VBN cord-335975-m6lkrehi 2080 44 by by IN cord-335975-m6lkrehi 2080 45 P p NN cord-335975-m6lkrehi 2080 46 F f NN cord-335975-m6lkrehi 2080 47 < < XX cord-335975-m6lkrehi 2080 48 300 300 CD cord-335975-m6lkrehi 2080 49 mmHg mmHg NNS cord-335975-m6lkrehi 2080 50 ) ) -RRB- cord-335975-m6lkrehi 2080 51 . . . cord-335975-m6lkrehi 2081 1 We -PRON- PRP cord-335975-m6lkrehi 2081 2 included include VBD cord-335975-m6lkrehi 2081 3 in in IN cord-335975-m6lkrehi 2081 4 the the DT cord-335975-m6lkrehi 2081 5 analysis analysis NN cord-335975-m6lkrehi 2081 6 all all DT cord-335975-m6lkrehi 2081 7 patients patient NNS cord-335975-m6lkrehi 2081 8 under under IN cord-335975-m6lkrehi 2081 9 mechanical mechanical JJ cord-335975-m6lkrehi 2081 10 ventilation ventilation NN cord-335975-m6lkrehi 2081 11 with with IN cord-335975-m6lkrehi 2081 12 SpO2 SpO2 NNP cord-335975-m6lkrehi 2081 13 < < XX cord-335975-m6lkrehi 2081 14 98 98 CD cord-335975-m6lkrehi 2081 15 % % NN cord-335975-m6lkrehi 2081 16 ( ( -LRB- cord-335975-m6lkrehi 2081 17 according accord VBG cord-335975-m6lkrehi 2081 18 to to IN cord-335975-m6lkrehi 2081 19 limit limit NN cord-335975-m6lkrehi 2081 20 of of IN cord-335975-m6lkrehi 2081 21 the the DT cord-335975-m6lkrehi 2081 22 Rice Rice NNP cord-335975-m6lkrehi 2081 23 study study NN cord-335975-m6lkrehi 2081 24 ) ) -RRB- cord-335975-m6lkrehi 2081 25 . . . cord-335975-m6lkrehi 2082 1 SpO2 SpO2 NNP cord-335975-m6lkrehi 2082 2 and and CC cord-335975-m6lkrehi 2082 3 FiO2 FiO2 NNS cord-335975-m6lkrehi 2082 4 were be VBD cord-335975-m6lkrehi 2082 5 measured measure VBN cord-335975-m6lkrehi 2082 6 simultaneously simultaneously RB cord-335975-m6lkrehi 2082 7 to to IN cord-335975-m6lkrehi 2083 1 arterial arterial JJ cord-335975-m6lkrehi 2083 2 blood blood NN cord-335975-m6lkrehi 2083 3 gas gas NN cord-335975-m6lkrehi 2083 4 were be VBD cord-335975-m6lkrehi 2083 5 drawn draw VBN cord-335975-m6lkrehi 2083 6 . . . cord-335975-m6lkrehi 2084 1 Results result NNS cord-335975-m6lkrehi 2084 2 : : : cord-335975-m6lkrehi 2085 1 Among among IN cord-335975-m6lkrehi 2085 2 1656 1656 CD cord-335975-m6lkrehi 2085 3 Patients patient NNS cord-335975-m6lkrehi 2085 4 of of IN cord-335975-m6lkrehi 2085 5 the the DT cord-335975-m6lkrehi 2085 6 SPECTRUM SPECTRUM NNP cord-335975-m6lkrehi 2085 7 study study NN cord-335975-m6lkrehi 2085 8 , , , cord-335975-m6lkrehi 2085 9 421 421 CD cord-335975-m6lkrehi 2085 10 were be VBD cord-335975-m6lkrehi 2085 11 on on IN cord-335975-m6lkrehi 2085 12 mechanical mechanical JJ cord-335975-m6lkrehi 2085 13 ventilation ventilation NN cord-335975-m6lkrehi 2085 14 and and CC cord-335975-m6lkrehi 2085 15 had have VBD cord-335975-m6lkrehi 2085 16 undergone undergo VBN cord-335975-m6lkrehi 2085 17 arterial arterial JJ cord-335975-m6lkrehi 2085 18 blood blood NN cord-335975-m6lkrehi 2085 19 gas gas NN cord-335975-m6lkrehi 2085 20 with with IN cord-335975-m6lkrehi 2085 21 simultaneously simultaneously RB cord-335975-m6lkrehi 2085 22 recorded record VBN cord-335975-m6lkrehi 2085 23 SpO2 SpO2 NNP cord-335975-m6lkrehi 2085 24 and and CC cord-335975-m6lkrehi 2085 25 FiO2 FiO2 NNS cord-335975-m6lkrehi 2085 26 . . . cord-335975-m6lkrehi 2086 1 Of of IN cord-335975-m6lkrehi 2086 2 note note NN cord-335975-m6lkrehi 2086 3 , , , cord-335975-m6lkrehi 2086 4 P p NN cord-335975-m6lkrehi 2086 5 F F NNP cord-335975-m6lkrehi 2086 6 was be VBD cord-335975-m6lkrehi 2086 7 < < NNP cord-335975-m6lkrehi 2086 8 100 100 CD cord-335975-m6lkrehi 2086 9 mmHg mmHg NNS cord-335975-m6lkrehi 2086 10 for for IN cord-335975-m6lkrehi 2086 11 132 132 CD cord-335975-m6lkrehi 2086 12 + + CD cord-335975-m6lkrehi 2086 13 between between IN cord-335975-m6lkrehi 2086 14 100 100 CD cord-335975-m6lkrehi 2086 15 and and CC cord-335975-m6lkrehi 2086 16 200 200 CD cord-335975-m6lkrehi 2086 17 for for IN cord-335975-m6lkrehi 2086 18 191 191 CD cord-335975-m6lkrehi 2086 19 + + CC cord-335975-m6lkrehi 2086 20 and and CC cord-335975-m6lkrehi 2086 21 between between IN cord-335975-m6lkrehi 2086 22 200 200 CD cord-335975-m6lkrehi 2086 23 and and CC cord-335975-m6lkrehi 2086 24 300 300 CD cord-335975-m6lkrehi 2086 25 for for IN cord-335975-m6lkrehi 2086 26 29 29 CD cord-335975-m6lkrehi 2086 27 . . . cord-335975-m6lkrehi 2087 1 Pairwise pairwise JJ cord-335975-m6lkrehi 2087 2 correlations correlation NNS cord-335975-m6lkrehi 2087 3 of of IN cord-335975-m6lkrehi 2087 4 truth truth NN cord-335975-m6lkrehi 2087 5 P p NN cord-335975-m6lkrehi 2087 6 F F NNP cord-335975-m6lkrehi 2087 7 with with IN cord-335975-m6lkrehi 2087 8 estimated estimate VBN cord-335975-m6lkrehi 2087 9 P p NN cord-335975-m6lkrehi 2087 10 F F NNP cord-335975-m6lkrehi 2087 11 was be VBD cord-335975-m6lkrehi 2087 12 good good JJ cord-335975-m6lkrehi 2087 13 ( ( -LRB- cord-335975-m6lkrehi 2087 14 Rice Rice NNP cord-335975-m6lkrehi 2087 15 - - HYPH cord-335975-m6lkrehi 2087 16 Spearman Spearman NNP cord-335975-m6lkrehi 2087 17 's 's POS cord-335975-m6lkrehi 2087 18 rho rho NN cord-335975-m6lkrehi 2087 19 = = SYM cord-335975-m6lkrehi 2087 20 0.84 0.84 CD cord-335975-m6lkrehi 2087 21 , , , cord-335975-m6lkrehi 2087 22 p p NN cord-335975-m6lkrehi 2087 23 < < XX cord-335975-m6lkrehi 2087 24 0.001-Ellis 0.001-ellis IN cord-335975-m6lkrehi 2087 25 - - HYPH cord-335975-m6lkrehi 2087 26 rho rho NN cord-335975-m6lkrehi 2087 27 = = NN cord-335975-m6lkrehi 2087 28 .85 .85 CD cord-335975-m6lkrehi 2087 29 p p NN cord-335975-m6lkrehi 2087 30 < < XX cord-335975-m6lkrehi 2087 31 0.001 0.001 CD cord-335975-m6lkrehi 2087 32 ) ) -RRB- cord-335975-m6lkrehi 2087 33 . . . cord-335975-m6lkrehi 2088 1 Bland Bland NNP cord-335975-m6lkrehi 2088 2 - - HYPH cord-335975-m6lkrehi 2088 3 Altmann Altmann NNP cord-335975-m6lkrehi 2088 4 test test NN cord-335975-m6lkrehi 2088 5 showed show VBD cord-335975-m6lkrehi 2088 6 an an DT cord-335975-m6lkrehi 2088 7 important important JJ cord-335975-m6lkrehi 2088 8 variability variability NN cord-335975-m6lkrehi 2088 9 of of IN cord-335975-m6lkrehi 2088 10 results result NNS cord-335975-m6lkrehi 2088 11 ( ( -LRB- cord-335975-m6lkrehi 2088 12 P p NN cord-335975-m6lkrehi 2088 13 F F NNP cord-335975-m6lkrehi 2088 14 vs vs IN cord-335975-m6lkrehi 2088 15 Rice Rice NNP cord-335975-m6lkrehi 2088 16 ( ( -LRB- cord-335975-m6lkrehi 2088 17 Figure figure NN cord-335975-m6lkrehi 2088 18 ) ) -RRB- cord-335975-m6lkrehi 2089 1 -0.02 -0.02 CD cord-335975-m6lkrehi 2090 1 ± ± NNP cord-335975-m6lkrehi 2090 2 57.8-P 57.8-p CD cord-335975-m6lkrehi 2090 3 F F NNP cord-335975-m6lkrehi 2091 1 vs vs IN cord-335975-m6lkrehi 2091 2 Ellis-14.3 Ellis-14.3 NNP cord-335975-m6lkrehi 2091 3 ± ± NNP cord-335975-m6lkrehi 2091 4 45.5 45.5 CD cord-335975-m6lkrehi 2091 5 ) ) -RRB- cord-335975-m6lkrehi 2091 6 . . . cord-335975-m6lkrehi 2092 1 The the DT cord-335975-m6lkrehi 2092 2 variability variability NN cord-335975-m6lkrehi 2092 3 decreased decrease VBD cord-335975-m6lkrehi 2092 4 with with IN cord-335975-m6lkrehi 2092 5 lower low JJR cord-335975-m6lkrehi 2092 6 P p NN cord-335975-m6lkrehi 2092 7 F. f. NN cord-335975-m6lkrehi 2092 8 Caution caution NN cord-335975-m6lkrehi 2092 9 may may MD cord-335975-m6lkrehi 2092 10 be be VB cord-335975-m6lkrehi 2092 11 used use VBN cord-335975-m6lkrehi 2092 12 to to TO cord-335975-m6lkrehi 2092 13 interpret interpret VB cord-335975-m6lkrehi 2092 14 our -PRON- PRP$ cord-335975-m6lkrehi 2092 15 results result NNS cord-335975-m6lkrehi 2092 16 because because IN cord-335975-m6lkrehi 2092 17 we -PRON- PRP cord-335975-m6lkrehi 2092 18 did do VBD cord-335975-m6lkrehi 2092 19 not not RB cord-335975-m6lkrehi 2092 20 reported report VBD cord-335975-m6lkrehi 2092 21 the the DT cord-335975-m6lkrehi 2092 22 quality quality NN cord-335975-m6lkrehi 2092 23 of of IN cord-335975-m6lkrehi 2092 24 SpO2 SpO2 NNP cord-335975-m6lkrehi 2092 25 signal signal NN cord-335975-m6lkrehi 2092 26 at at IN cord-335975-m6lkrehi 2092 27 the the DT cord-335975-m6lkrehi 2092 28 bedside bedside NN cord-335975-m6lkrehi 2092 29 . . . cord-335975-m6lkrehi 2093 1 Conclusion conclusion NN cord-335975-m6lkrehi 2093 2 : : : cord-335975-m6lkrehi 2093 3 Regarding regard VBG cord-335975-m6lkrehi 2093 4 the the DT cord-335975-m6lkrehi 2093 5 variability variability NN cord-335975-m6lkrehi 2093 6 of of IN cord-335975-m6lkrehi 2093 7 the the DT cord-335975-m6lkrehi 2093 8 results result NNS cord-335975-m6lkrehi 2093 9 , , , cord-335975-m6lkrehi 2093 10 whatever whatever WDT cord-335975-m6lkrehi 2093 11 the the DT cord-335975-m6lkrehi 2093 12 used use VBN cord-335975-m6lkrehi 2093 13 equation equation NN cord-335975-m6lkrehi 2093 14 , , , cord-335975-m6lkrehi 2093 15 caution caution NN cord-335975-m6lkrehi 2093 16 may may MD cord-335975-m6lkrehi 2093 17 be be VB cord-335975-m6lkrehi 2093 18 used use VBN cord-335975-m6lkrehi 2093 19 to to TO cord-335975-m6lkrehi 2093 20 predict predict VB cord-335975-m6lkrehi 2093 21 the the DT cord-335975-m6lkrehi 2093 22 P p NN cord-335975-m6lkrehi 2093 23 F f NN cord-335975-m6lkrehi 2093 24 by by IN cord-335975-m6lkrehi 2093 25 the the DT cord-335975-m6lkrehi 2093 26 SpO2 SpO2 NNP cord-335975-m6lkrehi 2093 27 FiO2 FiO2 NNP cord-335975-m6lkrehi 2093 28 ratio ratio NN cord-335975-m6lkrehi 2093 29 in in IN cord-335975-m6lkrehi 2093 30 patients patient NNS cord-335975-m6lkrehi 2093 31 under under IN cord-335975-m6lkrehi 2093 32 mechanical mechanical JJ cord-335975-m6lkrehi 2093 33 ventilation ventilation NN cord-335975-m6lkrehi 2093 34 . . . cord-335975-m6lkrehi 2094 1 Introduction introduction NN cord-335975-m6lkrehi 2094 2 : : : cord-335975-m6lkrehi 2095 1 Morbid morbid JJ cord-335975-m6lkrehi 2095 2 obesity obesity NN cord-335975-m6lkrehi 2095 3 and and CC cord-335975-m6lkrehi 2095 4 ARDS ARDS NNP cord-335975-m6lkrehi 2095 5 both both DT cord-335975-m6lkrehi 2095 6 affect affect VBP cord-335975-m6lkrehi 2095 7 respiratory respiratory JJ cord-335975-m6lkrehi 2095 8 mechanics mechanic NNS cord-335975-m6lkrehi 2095 9 mainly mainly RB cord-335975-m6lkrehi 2095 10 through through IN cord-335975-m6lkrehi 2095 11 their -PRON- PRP$ cord-335975-m6lkrehi 2095 12 respective respective JJ cord-335975-m6lkrehi 2095 13 impacts impact NNS cord-335975-m6lkrehi 2095 14 on on IN cord-335975-m6lkrehi 2095 15 chest chest NN cord-335975-m6lkrehi 2095 16 wall wall NN cord-335975-m6lkrehi 2095 17 and and CC cord-335975-m6lkrehi 2095 18 lung lung NN cord-335975-m6lkrehi 2095 19 elastances elastance NNS cord-335975-m6lkrehi 2095 20 . . . cord-335975-m6lkrehi 2096 1 We -PRON- PRP cord-335975-m6lkrehi 2096 2 present present VBP cord-335975-m6lkrehi 2096 3 a a DT cord-335975-m6lkrehi 2096 4 unique unique JJ cord-335975-m6lkrehi 2096 5 series series NN cord-335975-m6lkrehi 2096 6 of of IN cord-335975-m6lkrehi 2096 7 patients patient NNS cord-335975-m6lkrehi 2096 8 combining combine VBG cord-335975-m6lkrehi 2096 9 very very RB cord-335975-m6lkrehi 2096 10 severe severe JJ cord-335975-m6lkrehi 2096 11 morbid morbid JJ cord-335975-m6lkrehi 2096 12 obesity obesity NN cord-335975-m6lkrehi 2096 13 and and CC cord-335975-m6lkrehi 2096 14 moderate moderate JJ cord-335975-m6lkrehi 2096 15 to to TO cord-335975-m6lkrehi 2096 16 severe severe JJ cord-335975-m6lkrehi 2096 17 Acute acute JJ cord-335975-m6lkrehi 2096 18 Respiratory respiratory JJ cord-335975-m6lkrehi 2096 19 Distress Distress NNP cord-335975-m6lkrehi 2096 20 Syndrome Syndrome NNP cord-335975-m6lkrehi 2096 21 ( ( -LRB- cord-335975-m6lkrehi 2096 22 ARDS ARDS NNP cord-335975-m6lkrehi 2096 23 ) ) -RRB- cord-335975-m6lkrehi 2096 24 . . . cord-335975-m6lkrehi 2097 1 We -PRON- PRP cord-335975-m6lkrehi 2097 2 describe describe VBP cord-335975-m6lkrehi 2097 3 the the DT cord-335975-m6lkrehi 2097 4 use use NN cord-335975-m6lkrehi 2097 5 of of IN cord-335975-m6lkrehi 2097 6 trans trans JJ cord-335975-m6lkrehi 2097 7 - - JJ cord-335975-m6lkrehi 2097 8 pulmonary pulmonary JJ cord-335975-m6lkrehi 2097 9 pressures pressure NNS cord-335975-m6lkrehi 2097 10 ( ( -LRB- cord-335975-m6lkrehi 2097 11 TPP TPP NNP cord-335975-m6lkrehi 2097 12 ) ) -RRB- cord-335975-m6lkrehi 2097 13 measurements measurement NNS cord-335975-m6lkrehi 2097 14 for for IN cord-335975-m6lkrehi 2097 15 optimization optimization NN cord-335975-m6lkrehi 2097 16 of of IN cord-335975-m6lkrehi 2097 17 external external JJ cord-335975-m6lkrehi 2097 18 PEEP peep NN cord-335975-m6lkrehi 2097 19 setting set VBG cord-335975-m6lkrehi 2097 20 . . . cord-335975-m6lkrehi 2098 1 Patients patient NNS cord-335975-m6lkrehi 2098 2 and and CC cord-335975-m6lkrehi 2098 3 methods method NNS cord-335975-m6lkrehi 2098 4 : : : cord-335975-m6lkrehi 2098 5 The the DT cord-335975-m6lkrehi 2098 6 monocentric monocentric JJ cord-335975-m6lkrehi 2098 7 observational observational JJ cord-335975-m6lkrehi 2098 8 study study NN cord-335975-m6lkrehi 2098 9 was be VBD cord-335975-m6lkrehi 2098 10 performed perform VBN cord-335975-m6lkrehi 2098 11 in in IN cord-335975-m6lkrehi 2098 12 8 8 CD cord-335975-m6lkrehi 2098 13 morbidly morbidly RB cord-335975-m6lkrehi 2098 14 obese obese JJ cord-335975-m6lkrehi 2098 15 patients patient NNS cord-335975-m6lkrehi 2098 16 admitted admit VBN cord-335975-m6lkrehi 2098 17 for for IN cord-335975-m6lkrehi 2098 18 moderate moderate JJ cord-335975-m6lkrehi 2098 19 to to IN cord-335975-m6lkrehi 2098 20 severe severe JJ cord-335975-m6lkrehi 2098 21 ARDS ARDS NNP cord-335975-m6lkrehi 2098 22 . . . cord-335975-m6lkrehi 2099 1 We -PRON- PRP cord-335975-m6lkrehi 2099 2 performed perform VBD cord-335975-m6lkrehi 2099 3 an an DT cord-335975-m6lkrehi 2099 4 incremental incremental JJ cord-335975-m6lkrehi 2099 5 PEEP peep NN cord-335975-m6lkrehi 2099 6 trial trial NN cord-335975-m6lkrehi 2099 7 ( ( -LRB- cord-335975-m6lkrehi 2099 8 5 5 CD cord-335975-m6lkrehi 2099 9 cm cm NN cord-335975-m6lkrehi 2099 10 H2O h2o NN cord-335975-m6lkrehi 2099 11 steps step NNS cord-335975-m6lkrehi 2099 12 ) ) -RRB- cord-335975-m6lkrehi 2099 13 with with IN cord-335975-m6lkrehi 2099 14 TPP TPP NNP cord-335975-m6lkrehi 2099 15 measurement measurement NN cord-335975-m6lkrehi 2099 16 ( ( -LRB- cord-335975-m6lkrehi 2099 17 NutriVent NutriVent NNP cord-335975-m6lkrehi 2099 18 probe probe NN cord-335975-m6lkrehi 2099 19 , , , cord-335975-m6lkrehi 2099 20 Sidam Sidam NNP cord-335975-m6lkrehi 2099 21 , , , cord-335975-m6lkrehi 2099 22 Italy Italy NNP cord-335975-m6lkrehi 2099 23 ) ) -RRB- cord-335975-m6lkrehi 2099 24 in in IN cord-335975-m6lkrehi 2099 25 a a DT cord-335975-m6lkrehi 2099 26 semirecumbent semirecumbent NN cord-335975-m6lkrehi 2099 27 position position NN cord-335975-m6lkrehi 2099 28 as as IN cord-335975-m6lkrehi 2099 29 previously previously RB cord-335975-m6lkrehi 2099 30 described describe VBN cord-335975-m6lkrehi 2099 31 . . . cord-335975-m6lkrehi 2100 1 A a DT cord-335975-m6lkrehi 2100 2 decremental decremental JJ cord-335975-m6lkrehi 2100 3 PEEP PEEP NNP cord-335975-m6lkrehi 2100 4 trial trial NN cord-335975-m6lkrehi 2100 5 after after IN cord-335975-m6lkrehi 2100 6 a a DT cord-335975-m6lkrehi 2100 7 recruitment recruitment NN cord-335975-m6lkrehi 2100 8 maneuver maneuver NN cord-335975-m6lkrehi 2100 9 was be VBD cord-335975-m6lkrehi 2100 10 not not RB cord-335975-m6lkrehi 2100 11 performed perform VBN cord-335975-m6lkrehi 2100 12 since since IN cord-335975-m6lkrehi 2100 13 the the DT cord-335975-m6lkrehi 2100 14 safety safety NN cord-335975-m6lkrehi 2100 15 of of IN cord-335975-m6lkrehi 2100 16 such such PDT cord-335975-m6lkrehi 2100 17 a a DT cord-335975-m6lkrehi 2100 18 maneuver maneuver NN cord-335975-m6lkrehi 2100 19 in in IN cord-335975-m6lkrehi 2100 20 this this DT cord-335975-m6lkrehi 2100 21 specific specific JJ cord-335975-m6lkrehi 2100 22 population population NN cord-335975-m6lkrehi 2100 23 is be VBZ cord-335975-m6lkrehi 2100 24 largely largely RB cord-335975-m6lkrehi 2100 25 unknown unknown JJ cord-335975-m6lkrehi 2100 26 . . . cord-335975-m6lkrehi 2101 1 We -PRON- PRP cord-335975-m6lkrehi 2101 2 defined define VBD cord-335975-m6lkrehi 2101 3 two two CD cord-335975-m6lkrehi 2101 4 ways way NNS cord-335975-m6lkrehi 2101 5 for for IN cord-335975-m6lkrehi 2101 6 determination determination NN cord-335975-m6lkrehi 2101 7 of of IN cord-335975-m6lkrehi 2101 8 external external JJ cord-335975-m6lkrehi 2101 9 PEEP PEEP NNP cord-335975-m6lkrehi 2101 10 setting-(1 setting-(1 CD cord-335975-m6lkrehi 2101 11 ) ) -RRB- cord-335975-m6lkrehi 2102 1 PEEP peep VB cord-335975-m6lkrehi 2102 2 necessary necessary JJ cord-335975-m6lkrehi 2102 3 to to TO cord-335975-m6lkrehi 2102 4 obtain obtain VB cord-335975-m6lkrehi 2102 5 a a DT cord-335975-m6lkrehi 2102 6 positive positive JJ cord-335975-m6lkrehi 2102 7 expiratory expiratory NN cord-335975-m6lkrehi 2102 8 TPP tpp NN cord-335975-m6lkrehi 2103 1 and and CC cord-335975-m6lkrehi 2103 2 ( ( -LRB- cord-335975-m6lkrehi 2103 3 2 2 LS cord-335975-m6lkrehi 2103 4 ) ) -RRB- cord-335975-m6lkrehi 2103 5 PEEP peep NN cord-335975-m6lkrehi 2103 6 necessary necessary JJ cord-335975-m6lkrehi 2103 7 to to TO cord-335975-m6lkrehi 2103 8 obtain obtain VB cord-335975-m6lkrehi 2103 9 a a DT cord-335975-m6lkrehi 2103 10 plateau plateau NN cord-335975-m6lkrehi 2103 11 pressure pressure NN cord-335975-m6lkrehi 2103 12 between between IN cord-335975-m6lkrehi 2104 1 28 28 CD cord-335975-m6lkrehi 2104 2 and and CC cord-335975-m6lkrehi 2104 3 30 30 CD cord-335975-m6lkrehi 2104 4 cm cm NN cord-335975-m6lkrehi 2104 5 H h NN cord-335975-m6lkrehi 2104 6 2 2 CD cord-335975-m6lkrehi 2104 7 O o NN cord-335975-m6lkrehi 2104 8 ( ( -LRB- cord-335975-m6lkrehi 2104 9 maximal maximal JJ cord-335975-m6lkrehi 2104 10 alveolar alveolar NN cord-335975-m6lkrehi 2104 11 recruitment recruitment NN cord-335975-m6lkrehi 2104 12 Express Express NNP cord-335975-m6lkrehi 2104 13 strategy strategy NN cord-335975-m6lkrehi 2104 14 ) ) -RRB- cord-335975-m6lkrehi 2104 15 . . . cord-335975-m6lkrehi 2105 1 Data datum NNS cord-335975-m6lkrehi 2105 2 are be VBP cord-335975-m6lkrehi 2105 3 expressed express VBN cord-335975-m6lkrehi 2105 4 as as IN cord-335975-m6lkrehi 2105 5 numbers number NNS cord-335975-m6lkrehi 2105 6 ( ( -LRB- cord-335975-m6lkrehi 2105 7 % % NN cord-335975-m6lkrehi 2105 8 ) ) -RRB- cord-335975-m6lkrehi 2105 9 and and CC cord-335975-m6lkrehi 2105 10 medians median NNS cord-335975-m6lkrehi 2105 11 ( ( -LRB- cord-335975-m6lkrehi 2105 12 interquartile interquartile JJ cord-335975-m6lkrehi 2105 13 range range NN cord-335975-m6lkrehi 2105 14 ) ) -RRB- cord-335975-m6lkrehi 2105 15 . . . cord-335975-m6lkrehi 2106 1 Statistical statistical JJ cord-335975-m6lkrehi 2106 2 analysis analysis NN cord-335975-m6lkrehi 2106 3 was be VBD cord-335975-m6lkrehi 2106 4 made make VBN cord-335975-m6lkrehi 2106 5 using use VBG cord-335975-m6lkrehi 2106 6 the the DT cord-335975-m6lkrehi 2106 7 XLSTAT xlstat NN cord-335975-m6lkrehi 2106 8 software software NN cord-335975-m6lkrehi 2106 9 . . . cord-335975-m6lkrehi 2107 1 Results result NNS cord-335975-m6lkrehi 2107 2 : : : cord-335975-m6lkrehi 2108 1 We -PRON- PRP cord-335975-m6lkrehi 2108 2 enrolled enrol VBD cord-335975-m6lkrehi 2108 3 during during IN cord-335975-m6lkrehi 2108 4 5 5 CD cord-335975-m6lkrehi 2108 5 years year NNS cord-335975-m6lkrehi 2108 6 8 8 CD cord-335975-m6lkrehi 2108 7 morbidly morbidly RB cord-335975-m6lkrehi 2108 8 obese obese JJ cord-335975-m6lkrehi 2108 9 patients patient NNS cord-335975-m6lkrehi 2108 10 ( ( -LRB- cord-335975-m6lkrehi 2108 11 BMI BMI NNP cord-335975-m6lkrehi 2108 12 63 63 CD cord-335975-m6lkrehi 2109 1 ( ( -LRB- cord-335975-m6lkrehi 2109 2 IR IR NNP cord-335975-m6lkrehi 2109 3 59 59 CD cord-335975-m6lkrehi 2109 4 - - SYM cord-335975-m6lkrehi 2109 5 69 69 CD cord-335975-m6lkrehi 2109 6 ) ) -RRB- cord-335975-m6lkrehi 2109 7 ) ) -RRB- cord-335975-m6lkrehi 2109 8 admitted admit VBD cord-335975-m6lkrehi 2109 9 for for IN cord-335975-m6lkrehi 2109 10 a a DT cord-335975-m6lkrehi 2109 11 moderate moderate JJ cord-335975-m6lkrehi 2109 12 to to TO cord-335975-m6lkrehi 2109 13 severe severe JJ cord-335975-m6lkrehi 2109 14 ARDS ARDS NNP cord-335975-m6lkrehi 2109 15 . . . cord-335975-m6lkrehi 2110 1 Clinical clinical JJ cord-335975-m6lkrehi 2110 2 characteristics characteristic NNS cord-335975-m6lkrehi 2110 3 are be VBP cord-335975-m6lkrehi 2110 4 displayed display VBN cord-335975-m6lkrehi 2110 5 in in IN cord-335975-m6lkrehi 2110 6 Table Table NNP cord-335975-m6lkrehi 2110 7 1 1 CD cord-335975-m6lkrehi 2110 8 . . . cord-335975-m6lkrehi 2111 1 The the DT cord-335975-m6lkrehi 2111 2 Express Express NNP cord-335975-m6lkrehi 2111 3 strategy strategy NN cord-335975-m6lkrehi 2111 4 indicated indicate VBD cord-335975-m6lkrehi 2111 5 a a DT cord-335975-m6lkrehi 2111 6 PEEP peep NN cord-335975-m6lkrehi 2111 7 setting setting NN cord-335975-m6lkrehi 2111 8 of of IN cord-335975-m6lkrehi 2111 9 15 15 CD cord-335975-m6lkrehi 2111 10 cm cm NN cord-335975-m6lkrehi 2111 11 H h NN cord-335975-m6lkrehi 2111 12 2 2 CD cord-335975-m6lkrehi 2111 13 O o NN cord-335975-m6lkrehi 2111 14 ( ( -LRB- cord-335975-m6lkrehi 2111 15 IR IR NNP cord-335975-m6lkrehi 2111 16 15 15 CD cord-335975-m6lkrehi 2111 17 - - SYM cord-335975-m6lkrehi 2111 18 20 20 CD cord-335975-m6lkrehi 2111 19 ) ) -RRB- cord-335975-m6lkrehi 2111 20 whereas whereas IN cord-335975-m6lkrehi 2111 21 TPP TPP NNP cord-335975-m6lkrehi 2111 22 - - HYPH cord-335975-m6lkrehi 2111 23 guided guide VBN cord-335975-m6lkrehi 2111 24 PEEP PEEP NNP cord-335975-m6lkrehi 2111 25 was be VBD cord-335975-m6lkrehi 2111 26 30 30 CD cord-335975-m6lkrehi 2111 27 cm cm NN cord-335975-m6lkrehi 2111 28 H h NN cord-335975-m6lkrehi 2111 29 2 2 CD cord-335975-m6lkrehi 2111 30 O o NN cord-335975-m6lkrehi 2112 1 ( ( -LRB- cord-335975-m6lkrehi 2112 2 IR IR NNP cord-335975-m6lkrehi 2112 3 25 25 CD cord-335975-m6lkrehi 2112 4 - - SYM cord-335975-m6lkrehi 2112 5 32 32 CD cord-335975-m6lkrehi 2112 6 ) ) -RRB- cord-335975-m6lkrehi 2112 7 , , , cord-335975-m6lkrehi 2112 8 p p NN cord-335975-m6lkrehi 2112 9 = = SYM cord-335975-m6lkrehi 2112 10 0.03 0.03 CD cord-335975-m6lkrehi 2112 11 . . . cord-335975-m6lkrehi 2113 1 Driving drive VBG cord-335975-m6lkrehi 2113 2 pressure pressure NN cord-335975-m6lkrehi 2113 3 was be VBD cord-335975-m6lkrehi 2113 4 higher high JJR cord-335975-m6lkrehi 2113 5 in in IN cord-335975-m6lkrehi 2113 6 the the DT cord-335975-m6lkrehi 2113 7 Express Express NNP cord-335975-m6lkrehi 2113 8 strategy strategy NN cord-335975-m6lkrehi 2113 9 PEEP peep NN cord-335975-m6lkrehi 2113 10 setting set VBG cord-335975-m6lkrehi 2113 11 ( ( -LRB- cord-335975-m6lkrehi 2113 12 10.7 10.7 CD cord-335975-m6lkrehi 2113 13 cm cm NNS cord-335975-m6lkrehi 2113 14 H20 H20 NNP cord-335975-m6lkrehi 2113 15 ( ( -LRB- cord-335975-m6lkrehi 2113 16 IR IR NNP cord-335975-m6lkrehi 2113 17 9 9 CD cord-335975-m6lkrehi 2113 18 - - SYM cord-335975-m6lkrehi 2113 19 12 12 CD cord-335975-m6lkrehi 2113 20 ) ) -RRB- cord-335975-m6lkrehi 2113 21 ) ) -RRB- cord-335975-m6lkrehi 2113 22 than than IN cord-335975-m6lkrehi 2113 23 in in IN cord-335975-m6lkrehi 2113 24 the the DT cord-335975-m6lkrehi 2113 25 TPP TPP NNP cord-335975-m6lkrehi 2113 26 - - HYPH cord-335975-m6lkrehi 2113 27 guided guide VBN cord-335975-m6lkrehi 2113 28 PEEP PEEP NNP cord-335975-m6lkrehi 2113 29 ( ( -LRB- cord-335975-m6lkrehi 2113 30 10.2 10.2 CD cord-335975-m6lkrehi 2113 31 cm cm NNS cord-335975-m6lkrehi 2113 32 H20 H20 NNP cord-335975-m6lkrehi 2113 33 ( ( -LRB- cord-335975-m6lkrehi 2113 34 IR IR NNP cord-335975-m6lkrehi 2113 35 9.5 9.5 CD cord-335975-m6lkrehi 2113 36 - - SYM cord-335975-m6lkrehi 2113 37 13 13 CD cord-335975-m6lkrehi 2113 38 ) ) -RRB- cord-335975-m6lkrehi 2113 39 ) ) -RRB- cord-335975-m6lkrehi 2113 40 , , , cord-335975-m6lkrehi 2113 41 p p NN cord-335975-m6lkrehi 2113 42 = = SYM cord-335975-m6lkrehi 2113 43 0.92 0.92 CD cord-335975-m6lkrehi 2113 44 . . . cord-335975-m6lkrehi 2114 1 TPP TPP NNP cord-335975-m6lkrehi 2114 2 - - HYPH cord-335975-m6lkrehi 2114 3 guided guide VBN cord-335975-m6lkrehi 2114 4 PEEP peep NN cord-335975-m6lkrehi 2114 5 setting setting NN cord-335975-m6lkrehi 2114 6 was be VBD cord-335975-m6lkrehi 2114 7 higher high JJR cord-335975-m6lkrehi 2114 8 than than IN cord-335975-m6lkrehi 2114 9 indicated indicate VBN cord-335975-m6lkrehi 2114 10 by by IN cord-335975-m6lkrehi 2114 11 the the DT cord-335975-m6lkrehi 2114 12 Express Express NNP cord-335975-m6lkrehi 2114 13 strategy strategy NN cord-335975-m6lkrehi 2114 14 in in IN cord-335975-m6lkrehi 2114 15 all all DT cord-335975-m6lkrehi 2114 16 but but IN cord-335975-m6lkrehi 2114 17 one one CD cord-335975-m6lkrehi 2114 18 patient patient NN cord-335975-m6lkrehi 2114 19 . . . cord-335975-m6lkrehi 2115 1 One one CD cord-335975-m6lkrehi 2115 2 patient patient NN cord-335975-m6lkrehi 2115 3 suffered suffer VBD cord-335975-m6lkrehi 2115 4 from from IN cord-335975-m6lkrehi 2115 5 transient transient JJ cord-335975-m6lkrehi 2115 6 hypotension hypotension NN cord-335975-m6lkrehi 2115 7 when when WRB cord-335975-m6lkrehi 2115 8 external external JJ cord-335975-m6lkrehi 2115 9 PEEP peep NN cord-335975-m6lkrehi 2115 10 was be VBD cord-335975-m6lkrehi 2115 11 set set VBN cord-335975-m6lkrehi 2115 12 at at IN cord-335975-m6lkrehi 2115 13 25 25 CD cord-335975-m6lkrehi 2115 14 cm cm NNS cord-335975-m6lkrehi 2115 15 H h NN cord-335975-m6lkrehi 2115 16 2 2 CD cord-335975-m6lkrehi 2115 17 O o NN cord-335975-m6lkrehi 2115 18 , , , cord-335975-m6lkrehi 2115 19 while while IN cord-335975-m6lkrehi 2115 20 no no DT cord-335975-m6lkrehi 2115 21 patient patient NN cord-335975-m6lkrehi 2115 22 displayed display VBD cord-335975-m6lkrehi 2115 23 an an DT cord-335975-m6lkrehi 2115 24 inspiratory inspiratory JJ cord-335975-m6lkrehi 2115 25 TPP tpp NN cord-335975-m6lkrehi 2115 26 higher high JJR cord-335975-m6lkrehi 2115 27 than than IN cord-335975-m6lkrehi 2115 28 25 25 CD cord-335975-m6lkrehi 2115 29 cm cm NNS cord-335975-m6lkrehi 2115 30 H h NN cord-335975-m6lkrehi 2115 31 2 2 CD cord-335975-m6lkrehi 2116 1 O. O. NNP cord-335975-m6lkrehi 2116 2 Additional additional JJ cord-335975-m6lkrehi 2116 3 data datum NNS cord-335975-m6lkrehi 2116 4 will will MD cord-335975-m6lkrehi 2116 5 be be VB cord-335975-m6lkrehi 2116 6 provided provide VBN cord-335975-m6lkrehi 2116 7 during during IN cord-335975-m6lkrehi 2116 8 the the DT cord-335975-m6lkrehi 2116 9 meeting meeting NN cord-335975-m6lkrehi 2116 10 - - HYPH cord-335975-m6lkrehi 2116 11 pressure pressure NN cord-335975-m6lkrehi 2116 12 - - HYPH cord-335975-m6lkrehi 2116 13 volume volume NN cord-335975-m6lkrehi 2116 14 curve curve NN cord-335975-m6lkrehi 2116 15 at at IN cord-335975-m6lkrehi 2116 16 ZEEP ZEEP NNP cord-335975-m6lkrehi 2116 17 ( ( -LRB- cord-335975-m6lkrehi 2116 18 6 6 CD cord-335975-m6lkrehi 2116 19 patients patient NNS cord-335975-m6lkrehi 2116 20 ) ) -RRB- cord-335975-m6lkrehi 2116 21 , , , cord-335975-m6lkrehi 2116 22 CRF CRF NNP cord-335975-m6lkrehi 2116 23 measurements measurement NNS cord-335975-m6lkrehi 2116 24 ( ( -LRB- cord-335975-m6lkrehi 2116 25 4 4 CD cord-335975-m6lkrehi 2116 26 patients patient NNS cord-335975-m6lkrehi 2116 27 ) ) -RRB- cord-335975-m6lkrehi 2116 28 and and CC cord-335975-m6lkrehi 2116 29 ABG ABG NNP cord-335975-m6lkrehi 2116 30 and and CC cord-335975-m6lkrehi 2116 31 capnometry capnometry NNP cord-335975-m6lkrehi 2116 32 values value NNS cord-335975-m6lkrehi 2116 33 at at IN cord-335975-m6lkrehi 2116 34 each each DT cord-335975-m6lkrehi 2116 35 PEEP peep NN cord-335975-m6lkrehi 2116 36 level level NN cord-335975-m6lkrehi 2116 37 ( ( -LRB- cord-335975-m6lkrehi 2116 38 3 3 CD cord-335975-m6lkrehi 2116 39 patients patient NNS cord-335975-m6lkrehi 2116 40 ) ) -RRB- cord-335975-m6lkrehi 2116 41 . . . cord-335975-m6lkrehi 2117 1 In in IN cord-335975-m6lkrehi 2117 2 our -PRON- PRP$ cord-335975-m6lkrehi 2117 3 ARDS ARDS NNP cord-335975-m6lkrehi 2117 4 patients patient NNS cord-335975-m6lkrehi 2117 5 with with IN cord-335975-m6lkrehi 2117 6 extremely extremely RB cord-335975-m6lkrehi 2117 7 severe severe JJ cord-335975-m6lkrehi 2117 8 obesity obesity NN cord-335975-m6lkrehi 2117 9 , , , cord-335975-m6lkrehi 2117 10 an an DT cord-335975-m6lkrehi 2117 11 incremental incremental JJ cord-335975-m6lkrehi 2117 12 PEEP peep NN cord-335975-m6lkrehi 2117 13 trial trial NN cord-335975-m6lkrehi 2117 14 with with IN cord-335975-m6lkrehi 2117 15 TPP TPP NNP cord-335975-m6lkrehi 2117 16 measurements measurement NNS cord-335975-m6lkrehi 2117 17 appeared appear VBD cord-335975-m6lkrehi 2117 18 to to TO cord-335975-m6lkrehi 2117 19 be be VB cord-335975-m6lkrehi 2117 20 safe safe JJ cord-335975-m6lkrehi 2117 21 and and CC cord-335975-m6lkrehi 2117 22 indicated indicate VBD cord-335975-m6lkrehi 2117 23 a a DT cord-335975-m6lkrehi 2117 24 PEEP peep NN cord-335975-m6lkrehi 2117 25 setting set VBG cord-335975-m6lkrehi 2117 26 significantly significantly RB cord-335975-m6lkrehi 2117 27 higher high JJR cord-335975-m6lkrehi 2117 28 than than IN cord-335975-m6lkrehi 2117 29 for for IN cord-335975-m6lkrehi 2117 30 the the DT cord-335975-m6lkrehi 2117 31 commonly commonly RB cord-335975-m6lkrehi 2117 32 - - HYPH cord-335975-m6lkrehi 2117 33 used use VBN cord-335975-m6lkrehi 2117 34 ARDS ARDS NNP cord-335975-m6lkrehi 2117 35 strategies strategy NNS cord-335975-m6lkrehi 2117 36 . . . cord-335975-m6lkrehi 2118 1 Such such JJ cord-335975-m6lkrehi 2118 2 an an DT cord-335975-m6lkrehi 2118 3 approach approach NN cord-335975-m6lkrehi 2118 4 deserves deserve VBZ cord-335975-m6lkrehi 2118 5 further further JJ cord-335975-m6lkrehi 2118 6 comparisons comparison NNS cord-335975-m6lkrehi 2118 7 with with IN cord-335975-m6lkrehi 2118 8 other other JJ cord-335975-m6lkrehi 2118 9 modalities modality NNS cord-335975-m6lkrehi 2118 10 of of IN cord-335975-m6lkrehi 2118 11 monitoring monitoring NN cord-335975-m6lkrehi 2118 12 , , , cord-335975-m6lkrehi 2118 13 such such JJ cord-335975-m6lkrehi 2118 14 as as IN cord-335975-m6lkrehi 2118 15 CRF CRF NNP cord-335975-m6lkrehi 2118 16 measurements measurement NNS cord-335975-m6lkrehi 2118 17 , , , cord-335975-m6lkrehi 2118 18 EIT EIT NNP cord-335975-m6lkrehi 2118 19 studies study NNS cord-335975-m6lkrehi 2118 20 , , , cord-335975-m6lkrehi 2118 21 etc etc FW cord-335975-m6lkrehi 2118 22 . . . cord-335975-m6lkrehi 2119 1 Severe severe JJ cord-335975-m6lkrehi 2119 2 poisoning poisoning NN cord-335975-m6lkrehi 2119 3 by by IN cord-335975-m6lkrehi 2119 4 cardiotoxic cardiotoxic JJ cord-335975-m6lkrehi 2119 5 drugs drug NNS cord-335975-m6lkrehi 2119 6 and and CC cord-335975-m6lkrehi 2119 7 circulatory circulatory JJ cord-335975-m6lkrehi 2119 8 assistance assistance NN cord-335975-m6lkrehi 2119 9 : : : cord-335975-m6lkrehi 2119 10 5-year 5-year CD cord-335975-m6lkrehi 2119 11 experience experience NN cord-335975-m6lkrehi 2119 12 at at IN cord-335975-m6lkrehi 2119 13 French french JJ cord-335975-m6lkrehi 2119 14 university university NN cord-335975-m6lkrehi 2119 15 hospital hospital NN cord-335975-m6lkrehi 2119 16 Tardif Tardif NNP cord-335975-m6lkrehi 2119 17 Elsa Elsa NNP cord-335975-m6lkrehi 2119 18 1 1 CD cord-335975-m6lkrehi 2119 19 , , , cord-335975-m6lkrehi 2119 20 Conil Conil NNP cord-335975-m6lkrehi 2119 21 Jean Jean NNP cord-335975-m6lkrehi 2119 22 - - HYPH cord-335975-m6lkrehi 2119 23 Marie Marie NNP cord-335975-m6lkrehi 2119 24 1 1 CD cord-335975-m6lkrehi 2119 25 , , , cord-335975-m6lkrehi 2119 26 Georges Georges NNP cord-335975-m6lkrehi 2119 27 Bernard Bernard NNP cord-335975-m6lkrehi 2119 28 1 1 CD cord-335975-m6lkrehi 2119 29 , , , cord-335975-m6lkrehi 2119 30 Marcheix Marcheix NNP cord-335975-m6lkrehi 2119 31 Bertrand Bertrand NNP cord-335975-m6lkrehi 2119 32 1 1 CD cord-335975-m6lkrehi 2119 33 , , , cord-335975-m6lkrehi 2119 34 Crognier Crognier NNP cord-335975-m6lkrehi 2119 35 Laure Laure NNP cord-335975-m6lkrehi 2119 36 1 1 CD cord-335975-m6lkrehi 2119 37 , , , cord-335975-m6lkrehi 2119 38 Bounes Bounes NNP cord-335975-m6lkrehi 2119 39 Fanny Fanny NNP cord-335975-m6lkrehi 2119 40 1 1 CD cord-335975-m6lkrehi 2119 41 , , , cord-335975-m6lkrehi 2119 42 Delmas Delmas NNP cord-335975-m6lkrehi 2119 43 Clement Clement NNP cord-335975-m6lkrehi 2120 1 1 1 CD cord-335975-m6lkrehi 2120 2 1 1 CD cord-335975-m6lkrehi 2120 3 CHU CHU NNP cord-335975-m6lkrehi 2120 4 Rangueil Rangueil NNP cord-335975-m6lkrehi 2120 5 , , , cord-335975-m6lkrehi 2120 6 Toulouse Toulouse NNP cord-335975-m6lkrehi 2120 7 , , , cord-335975-m6lkrehi 2120 8 France France NNP cord-335975-m6lkrehi 2120 9 Correspondence Correspondence NNP cord-335975-m6lkrehi 2120 10 : : : cord-335975-m6lkrehi 2121 1 Tardif Tardif NNP cord-335975-m6lkrehi 2121 2 Elsa Elsa NNP cord-335975-m6lkrehi 2121 3 -tardif.elsa@gmail.com -tardif.elsa@gmail.com HYPH cord-335975-m6lkrehi 2121 4 Annals Annals NNP cord-335975-m6lkrehi 2121 5 of of IN cord-335975-m6lkrehi 2121 6 Intensive Intensive NNP cord-335975-m6lkrehi 2121 7 Care Care NNP cord-335975-m6lkrehi 2121 8 2018 2018 CD cord-335975-m6lkrehi 2122 1 , , , cord-335975-m6lkrehi 2122 2 8(Suppl 8(suppl CD cord-335975-m6lkrehi 2122 3 1):F-106 1):f-106 CD cord-335975-m6lkrehi 2122 4 Introduction introduction NN cord-335975-m6lkrehi 2122 5 : : : cord-335975-m6lkrehi 2123 1 Toxicity toxicity NN cord-335975-m6lkrehi 2123 2 from from IN cord-335975-m6lkrehi 2123 3 cardiac cardiac JJ cord-335975-m6lkrehi 2123 4 drugs drug NNS cord-335975-m6lkrehi 2123 5 is be VBZ cord-335975-m6lkrehi 2123 6 associated associate VBN cord-335975-m6lkrehi 2123 7 with with IN cord-335975-m6lkrehi 2123 8 a a DT cord-335975-m6lkrehi 2123 9 large large JJ cord-335975-m6lkrehi 2123 10 number number NN cord-335975-m6lkrehi 2123 11 of of IN cord-335975-m6lkrehi 2123 12 fatalities fatality NNS cord-335975-m6lkrehi 2123 13 , , , cord-335975-m6lkrehi 2123 14 significant significant JJ cord-335975-m6lkrehi 2123 15 morbidity morbidity NN cord-335975-m6lkrehi 2123 16 and and CC cord-335975-m6lkrehi 2123 17 healthcare healthcare NN cord-335975-m6lkrehi 2123 18 consequences consequence NNS cord-335975-m6lkrehi 2123 19 . . . cord-335975-m6lkrehi 2124 1 Severity severity NN cord-335975-m6lkrehi 2124 2 of of IN cord-335975-m6lkrehi 2124 3 these these DT cord-335975-m6lkrehi 2124 4 poisonings poisoning NNS cord-335975-m6lkrehi 2124 5 can can MD cord-335975-m6lkrehi 2124 6 be be VB cord-335975-m6lkrehi 2124 7 explained explain VBN cord-335975-m6lkrehi 2124 8 by by IN cord-335975-m6lkrehi 2124 9 a a DT cord-335975-m6lkrehi 2124 10 refractory refractory JJ cord-335975-m6lkrehi 2124 11 cardiogenic cardiogenic JJ cord-335975-m6lkrehi 2124 12 shock shock NN cord-335975-m6lkrehi 2124 13 not not RB cord-335975-m6lkrehi 2124 14 responding respond VBG cord-335975-m6lkrehi 2124 15 to to IN cord-335975-m6lkrehi 2124 16 optimal optimal JJ cord-335975-m6lkrehi 2124 17 conventional conventional JJ cord-335975-m6lkrehi 2124 18 treatment treatment NN cord-335975-m6lkrehi 2124 19 . . . cord-335975-m6lkrehi 2125 1 Criteria criterion NNS cord-335975-m6lkrehi 2125 2 of of IN cord-335975-m6lkrehi 2125 3 circulatory circulatory JJ cord-335975-m6lkrehi 2125 4 assistance assistance NN cord-335975-m6lkrehi 2125 5 indications indication NNS cord-335975-m6lkrehi 2125 6 remain remain VBP cord-335975-m6lkrehi 2125 7 unclear unclear JJ cord-335975-m6lkrehi 2125 8 . . . cord-335975-m6lkrehi 2126 1 The the DT cord-335975-m6lkrehi 2126 2 aim aim NN cord-335975-m6lkrehi 2126 3 of of IN cord-335975-m6lkrehi 2126 4 the the DT cord-335975-m6lkrehi 2126 5 study study NN cord-335975-m6lkrehi 2126 6 was be VBD cord-335975-m6lkrehi 2126 7 to to TO cord-335975-m6lkrehi 2126 8 describe describe VB cord-335975-m6lkrehi 2126 9 and and CC cord-335975-m6lkrehi 2126 10 to to TO cord-335975-m6lkrehi 2126 11 compare compare VB cord-335975-m6lkrehi 2126 12 patients patient NNS cord-335975-m6lkrehi 2126 13 intoxicated intoxicate VBN cord-335975-m6lkrehi 2126 14 by by IN cord-335975-m6lkrehi 2126 15 cardiotoxic cardiotoxic JJ cord-335975-m6lkrehi 2126 16 drug drug NN cord-335975-m6lkrehi 2126 17 treated treat VBN cord-335975-m6lkrehi 2126 18 with with IN cord-335975-m6lkrehi 2126 19 or or CC cord-335975-m6lkrehi 2126 20 without without IN cord-335975-m6lkrehi 2126 21 veno veno NNP cord-335975-m6lkrehi 2126 22 - - HYPH cord-335975-m6lkrehi 2126 23 arterial arterial JJ cord-335975-m6lkrehi 2126 24 ExtraCorporeal ExtraCorporeal NNP cord-335975-m6lkrehi 2126 25 Membrane Membrane NNP cord-335975-m6lkrehi 2126 26 Oxygenation oxygenation NN cord-335975-m6lkrehi 2126 27 ( ( -LRB- cord-335975-m6lkrehi 2126 28 VA VA NNP cord-335975-m6lkrehi 2126 29 ECMO ECMO NNP cord-335975-m6lkrehi 2126 30 ) ) -RRB- cord-335975-m6lkrehi 2126 31 . . . cord-335975-m6lkrehi 2127 1 Patients patient NNS cord-335975-m6lkrehi 2127 2 and and CC cord-335975-m6lkrehi 2127 3 methods method NNS cord-335975-m6lkrehi 2127 4 : : : cord-335975-m6lkrehi 2127 5 Retrospective retrospective JJ cord-335975-m6lkrehi 2127 6 cohort cohort NN cord-335975-m6lkrehi 2127 7 study study NN cord-335975-m6lkrehi 2127 8 conducted conduct VBN cord-335975-m6lkrehi 2127 9 at at IN cord-335975-m6lkrehi 2127 10 French french JJ cord-335975-m6lkrehi 2127 11 university university NN cord-335975-m6lkrehi 2127 12 hospital hospital NN cord-335975-m6lkrehi 2127 13 . . . cord-335975-m6lkrehi 2128 1 All all DT cord-335975-m6lkrehi 2128 2 patients patient NNS cord-335975-m6lkrehi 2128 3 intoxicated intoxicate VBN cord-335975-m6lkrehi 2128 4 with with IN cord-335975-m6lkrehi 2128 5 cardiotoxic cardiotoxic JJ cord-335975-m6lkrehi 2128 6 drugs drug NNS cord-335975-m6lkrehi 2128 7 between between IN cord-335975-m6lkrehi 2128 8 January January NNP cord-335975-m6lkrehi 2128 9 2012 2012 CD cord-335975-m6lkrehi 2128 10 and and CC cord-335975-m6lkrehi 2128 11 March March NNP cord-335975-m6lkrehi 2128 12 2017 2017 CD cord-335975-m6lkrehi 2128 13 were be VBD cord-335975-m6lkrehi 2128 14 included include VBN cord-335975-m6lkrehi 2128 15 . . . cord-335975-m6lkrehi 2129 1 Patients patient NNS cord-335975-m6lkrehi 2129 2 were be VBD cord-335975-m6lkrehi 2129 3 divided divide VBN cord-335975-m6lkrehi 2129 4 into into IN cord-335975-m6lkrehi 2129 5 2 2 CD cord-335975-m6lkrehi 2129 6 groups group NNS cord-335975-m6lkrehi 2129 7 - - , cord-335975-m6lkrehi 2129 8 with with JJ cord-335975-m6lkrehi 2129 9 and and CC cord-335975-m6lkrehi 2129 10 without without IN cord-335975-m6lkrehi 2129 11 VA VA NNP cord-335975-m6lkrehi 2129 12 ECMO ECMO NNP cord-335975-m6lkrehi 2129 13 . . . cord-335975-m6lkrehi 2130 1 Results result NNS cord-335975-m6lkrehi 2130 2 : : : cord-335975-m6lkrehi 2131 1 Among among IN cord-335975-m6lkrehi 2131 2 the the DT cord-335975-m6lkrehi 2131 3 105 105 CD cord-335975-m6lkrehi 2131 4 patients patient NNS cord-335975-m6lkrehi 2131 5 included include VBN cord-335975-m6lkrehi 2131 6 in in IN cord-335975-m6lkrehi 2131 7 the the DT cord-335975-m6lkrehi 2131 8 study study NN cord-335975-m6lkrehi 2131 9 , , , cord-335975-m6lkrehi 2131 10 18 18 CD cord-335975-m6lkrehi 2131 11 patients patient NNS cord-335975-m6lkrehi 2131 12 were be VBD cord-335975-m6lkrehi 2131 13 treated treat VBN cord-335975-m6lkrehi 2131 14 with with IN cord-335975-m6lkrehi 2131 15 VA VA NNP cord-335975-m6lkrehi 2131 16 ECMO ECMO NNP cord-335975-m6lkrehi 2131 17 ( ( -LRB- cord-335975-m6lkrehi 2131 18 17 17 CD cord-335975-m6lkrehi 2131 19 % % NN cord-335975-m6lkrehi 2131 20 ) ) -RRB- cord-335975-m6lkrehi 2131 21 and and CC cord-335975-m6lkrehi 2131 22 87 87 CD cord-335975-m6lkrehi 2131 23 patients patient NNS cord-335975-m6lkrehi 2131 24 with with IN cord-335975-m6lkrehi 2131 25 conventional conventional JJ cord-335975-m6lkrehi 2131 26 therapies therapy NNS cord-335975-m6lkrehi 2131 27 . . . cord-335975-m6lkrehi 2132 1 ECMO ECMO NNP cord-335975-m6lkrehi 2132 2 was be VBD cord-335975-m6lkrehi 2132 3 respectively respectively RB cord-335975-m6lkrehi 2132 4 employed employ VBN cord-335975-m6lkrehi 2132 5 for for IN cord-335975-m6lkrehi 2132 6 refractory refractory JJ cord-335975-m6lkrehi 2132 7 shock shock NN cord-335975-m6lkrehi 2132 8 and and CC cord-335975-m6lkrehi 2132 9 cardiac cardiac JJ cord-335975-m6lkrehi 2132 10 arrest arrest NN cord-335975-m6lkrehi 2132 11 in in IN cord-335975-m6lkrehi 2132 12 13 13 CD cord-335975-m6lkrehi 2132 13 and and CC cord-335975-m6lkrehi 2132 14 5 5 CD cord-335975-m6lkrehi 2132 15 cases case NNS cord-335975-m6lkrehi 2132 16 , , , cord-335975-m6lkrehi 2133 1 all all DT cord-335975-m6lkrehi 2133 2 patient patient NN cord-335975-m6lkrehi 2133 3 required require VBD cord-335975-m6lkrehi 2133 4 vasopressor vasopressor NN cord-335975-m6lkrehi 2133 5 support support NN cord-335975-m6lkrehi 2133 6 . . . cord-335975-m6lkrehi 2134 1 In in IN cord-335975-m6lkrehi 2134 2 - - HYPH cord-335975-m6lkrehi 2134 3 hospital hospital NN cord-335975-m6lkrehi 2134 4 mortality mortality NN cord-335975-m6lkrehi 2134 5 was be VBD cord-335975-m6lkrehi 2134 6 10.5 10.5 CD cord-335975-m6lkrehi 2134 7 % % NN cord-335975-m6lkrehi 2134 8 and and CC cord-335975-m6lkrehi 2134 9 was be VBD cord-335975-m6lkrehi 2134 10 significantly significantly RB cord-335975-m6lkrehi 2134 11 higher high JJR cord-335975-m6lkrehi 2134 12 in in IN cord-335975-m6lkrehi 2134 13 the the DT cord-335975-m6lkrehi 2134 14 ECMO ECMO NNP cord-335975-m6lkrehi 2134 15 group group NN cord-335975-m6lkrehi 2134 16 ( ( -LRB- cord-335975-m6lkrehi 2134 17 44.4 44.4 CD cord-335975-m6lkrehi 2134 18 % % NN cord-335975-m6lkrehi 2134 19 ) ) -RRB- cord-335975-m6lkrehi 2134 20 . . . cord-335975-m6lkrehi 2135 1 Beta beta NN cord-335975-m6lkrehi 2135 2 - - HYPH cord-335975-m6lkrehi 2135 3 blockers blocker NNS cord-335975-m6lkrehi 2135 4 with with IN cord-335975-m6lkrehi 2135 5 membrane membrane NN cord-335975-m6lkrehi 2135 6 stabilizing stabilize VBG cord-335975-m6lkrehi 2135 7 activity activity NN cord-335975-m6lkrehi 2135 8 and and CC cord-335975-m6lkrehi 2135 9 non non JJ cord-335975-m6lkrehi 2135 10 - - JJ cord-335975-m6lkrehi 2135 11 dihydropyridine dihydropyridine JJ cord-335975-m6lkrehi 2135 12 calcium calcium NN cord-335975-m6lkrehi 2135 13 channel channel NN cord-335975-m6lkrehi 2135 14 blockers blocker NNS cord-335975-m6lkrehi 2135 15 poisoning poisoning NN cord-335975-m6lkrehi 2135 16 were be VBD cord-335975-m6lkrehi 2135 17 the the DT cord-335975-m6lkrehi 2135 18 most most RBS cord-335975-m6lkrehi 2135 19 commonly commonly RB cord-335975-m6lkrehi 2135 20 reported report VBN cord-335975-m6lkrehi 2135 21 in in IN cord-335975-m6lkrehi 2135 22 the the DT cord-335975-m6lkrehi 2135 23 ECMO ECMO NNP cord-335975-m6lkrehi 2135 24 group group NN cord-335975-m6lkrehi 2135 25 . . . cord-335975-m6lkrehi 2136 1 Mean mean JJ cord-335975-m6lkrehi 2136 2 time time NN cord-335975-m6lkrehi 2136 3 from from IN cord-335975-m6lkrehi 2136 4 hospital hospital NN cord-335975-m6lkrehi 2136 5 admission admission NN cord-335975-m6lkrehi 2136 6 to to IN cord-335975-m6lkrehi 2136 7 initiation initiation NN cord-335975-m6lkrehi 2136 8 of of IN cord-335975-m6lkrehi 2136 9 ECMO ECMO NNP cord-335975-m6lkrehi 2136 10 was be VBD cord-335975-m6lkrehi 2137 1 11 11 CD cord-335975-m6lkrehi 2137 2 h h NN cord-335975-m6lkrehi 2137 3 and and CC cord-335975-m6lkrehi 2137 4 the the DT cord-335975-m6lkrehi 2137 5 average average JJ cord-335975-m6lkrehi 2137 6 ECMO ECMO NNP cord-335975-m6lkrehi 2137 7 duration duration NN cord-335975-m6lkrehi 2137 8 was be VBD cord-335975-m6lkrehi 2137 9 2.6 2.6 CD cord-335975-m6lkrehi 2137 10 days day NNS cord-335975-m6lkrehi 2137 11 [ [ -LRB- cord-335975-m6lkrehi 2137 12 1 1 CD cord-335975-m6lkrehi 2137 13 ] ] -RRB- cord-335975-m6lkrehi 2137 14 [ [ -LRB- cord-335975-m6lkrehi 2137 15 2 2 CD cord-335975-m6lkrehi 2137 16 ] ] -RRB- cord-335975-m6lkrehi 2137 17 [ [ -LRB- cord-335975-m6lkrehi 2137 18 3 3 CD cord-335975-m6lkrehi 2137 19 ] ] -RRB- cord-335975-m6lkrehi 2137 20 [ [ -LRB- cord-335975-m6lkrehi 2137 21 4 4 CD cord-335975-m6lkrehi 2137 22 ] ] -RRB- cord-335975-m6lkrehi 2137 23 [ [ -LRB- cord-335975-m6lkrehi 2137 24 5 5 CD cord-335975-m6lkrehi 2137 25 ] ] -RRB- cord-335975-m6lkrehi 2137 26 [ [ -LRB- cord-335975-m6lkrehi 2137 27 6 6 CD cord-335975-m6lkrehi 2137 28 ] ] -RRB- cord-335975-m6lkrehi 2137 29 [ [ -LRB- cord-335975-m6lkrehi 2137 30 7 7 CD cord-335975-m6lkrehi 2137 31 ] ] -RRB- cord-335975-m6lkrehi 2137 32 [ [ -LRB- cord-335975-m6lkrehi 2137 33 8 8 CD cord-335975-m6lkrehi 2137 34 ] ] -RRB- cord-335975-m6lkrehi 2137 35 . . . cord-335975-m6lkrehi 2138 1 No no DT cord-335975-m6lkrehi 2138 2 serious serious JJ cord-335975-m6lkrehi 2138 3 adverse adverse JJ cord-335975-m6lkrehi 2138 4 reaction reaction NN cord-335975-m6lkrehi 2138 5 was be VBD cord-335975-m6lkrehi 2138 6 reported report VBN cord-335975-m6lkrehi 2138 7 during during IN cord-335975-m6lkrehi 2138 8 this this DT cord-335975-m6lkrehi 2138 9 period period NN cord-335975-m6lkrehi 2138 10 . . . cord-335975-m6lkrehi 2139 1 Results result NNS cord-335975-m6lkrehi 2139 2 expressed express VBN cord-335975-m6lkrehi 2139 3 in in IN cord-335975-m6lkrehi 2139 4 median median JJ cord-335975-m6lkrehi 2139 5 value value NN cord-335975-m6lkrehi 2139 6 ± ± NNP cord-335975-m6lkrehi 2139 7 confidence confidence NN cord-335975-m6lkrehi 2139 8 interval interval NN cord-335975-m6lkrehi 2139 9 Conclusion conclusion NN cord-335975-m6lkrehi 2139 10 : : : cord-335975-m6lkrehi 2139 11 Refractory refractory JJ cord-335975-m6lkrehi 2139 12 cardiogenic cardiogenic JJ cord-335975-m6lkrehi 2139 13 shock shock NN cord-335975-m6lkrehi 2139 14 following follow VBG cord-335975-m6lkrehi 2139 15 cardiotoxic cardiotoxic JJ cord-335975-m6lkrehi 2139 16 drug drug NN cord-335975-m6lkrehi 2139 17 poisoning poisoning NN cord-335975-m6lkrehi 2139 18 requiring require VBG cord-335975-m6lkrehi 2139 19 circulatory circulatory JJ cord-335975-m6lkrehi 2139 20 assistance assistance NN cord-335975-m6lkrehi 2139 21 is be VBZ cord-335975-m6lkrehi 2139 22 associated associate VBN cord-335975-m6lkrehi 2139 23 with with IN cord-335975-m6lkrehi 2139 24 significant significant JJ cord-335975-m6lkrehi 2139 25 mortality mortality NN cord-335975-m6lkrehi 2139 26 . . . cord-335975-m6lkrehi 2140 1 Even even RB cord-335975-m6lkrehi 2140 2 if if IN cord-335975-m6lkrehi 2140 3 its -PRON- PRP$ cord-335975-m6lkrehi 2140 4 use use NN cord-335975-m6lkrehi 2140 5 seems seem VBZ cord-335975-m6lkrehi 2140 6 justified justify VBN cord-335975-m6lkrehi 2140 7 by by IN cord-335975-m6lkrehi 2140 8 the the DT cord-335975-m6lkrehi 2140 9 literature literature NN cord-335975-m6lkrehi 2140 10 , , , cord-335975-m6lkrehi 2140 11 the the DT cord-335975-m6lkrehi 2140 12 implantation implantation NN cord-335975-m6lkrehi 2140 13 criteria criterion NNS cord-335975-m6lkrehi 2140 14 must must MD cord-335975-m6lkrehi 2140 15 be be VB cord-335975-m6lkrehi 2140 16 specified specify VBN cord-335975-m6lkrehi 2140 17 and and CC cord-335975-m6lkrehi 2140 18 this this DT cord-335975-m6lkrehi 2140 19 after after IN cord-335975-m6lkrehi 2140 20 an an DT cord-335975-m6lkrehi 2140 21 optimal optimal JJ cord-335975-m6lkrehi 2140 22 conventional conventional JJ cord-335975-m6lkrehi 2140 23 treatment treatment NN cord-335975-m6lkrehi 2140 24 to to TO cord-335975-m6lkrehi 2140 25 prevent prevent VB cord-335975-m6lkrehi 2140 26 multiple multiple JJ cord-335975-m6lkrehi 2140 27 organ organ NN cord-335975-m6lkrehi 2140 28 failure failure NN cord-335975-m6lkrehi 2140 29 . . . cord-335975-m6lkrehi 2141 1 The the DT cord-335975-m6lkrehi 2141 2 CDV CDV NNP cord-335975-m6lkrehi 2141 3 of of IN cord-335975-m6lkrehi 2141 4 patients patient NNS cord-335975-m6lkrehi 2141 5 in in IN cord-335975-m6lkrehi 2141 6 the the DT cord-335975-m6lkrehi 2141 7 EDASS EDASS NNP cord-335975-m6lkrehi 2141 8 group group NN cord-335975-m6lkrehi 2141 9 was be VBD cord-335975-m6lkrehi 2141 10 significantly significantly RB cord-335975-m6lkrehi 2141 11 higher high JJR cord-335975-m6lkrehi 2141 12 ( ( -LRB- cord-335975-m6lkrehi 2141 13 p p NN cord-335975-m6lkrehi 2141 14 < < XX cord-335975-m6lkrehi 2141 15 0.0001 0.0001 CD cord-335975-m6lkrehi 2141 16 ) ) -RRB- cord-335975-m6lkrehi 2141 17 at at IN cord-335975-m6lkrehi 2141 18 all all DT cord-335975-m6lkrehi 2141 19 - - HYPH cord-335975-m6lkrehi 2141 20 time time NN cord-335975-m6lkrehi 2141 21 points point NNS cord-335975-m6lkrehi 2141 22 after after IN cord-335975-m6lkrehi 2141 23 the the DT cord-335975-m6lkrehi 2141 24 introduction introduction NN cord-335975-m6lkrehi 2141 25 of of IN cord-335975-m6lkrehi 2141 26 catecholamines catecholamine NNS cord-335975-m6lkrehi 2141 27 than than IN cord-335975-m6lkrehi 2141 28 among among IN cord-335975-m6lkrehi 2141 29 those those DT cord-335975-m6lkrehi 2141 30 without without IN cord-335975-m6lkrehi 2141 31 EDASS EDASS NNP cord-335975-m6lkrehi 2141 32 , , , cord-335975-m6lkrehi 2141 33 as as RB cord-335975-m6lkrehi 2141 34 early early RB cord-335975-m6lkrehi 2141 35 as as IN cord-335975-m6lkrehi 2141 36 6 6 CD cord-335975-m6lkrehi 2141 37 h h NN cord-335975-m6lkrehi 2141 38 from from IN cord-335975-m6lkrehi 2141 39 catecholamine catecholamine NN cord-335975-m6lkrehi 2141 40 initiation initiation NN cord-335975-m6lkrehi 2141 41 ( ( -LRB- cord-335975-m6lkrehi 2141 42 Fig Fig NNP cord-335975-m6lkrehi 2141 43 . . . cord-335975-m6lkrehi 2141 44 1 1 CD cord-335975-m6lkrehi 2141 45 ) ) -RRB- cord-335975-m6lkrehi 2141 46 . . . cord-335975-m6lkrehi 2142 1 A a DT cord-335975-m6lkrehi 2142 2 strategy strategy NN cord-335975-m6lkrehi 2142 3 in in IN cord-335975-m6lkrehi 2142 4 two two CD cord-335975-m6lkrehi 2142 5 steps step NNS cord-335975-m6lkrehi 2142 6 ( ( -LRB- cord-335975-m6lkrehi 2142 7 CDV CDV NNP cord-335975-m6lkrehi 2142 8 > > XX cord-335975-m6lkrehi 2143 1 800 800 CD cord-335975-m6lkrehi 2143 2 µg µg NN cord-335975-m6lkrehi 2143 3 kg kg NNP cord-335975-m6lkrehi 2143 4 at at IN cord-335975-m6lkrehi 2143 5 6 6 CD cord-335975-m6lkrehi 2143 6 h h NN cord-335975-m6lkrehi 2143 7 and and CC cord-335975-m6lkrehi 2143 8 or or CC cord-335975-m6lkrehi 2143 9 CDV CDV NNP cord-335975-m6lkrehi 2144 1 > > XX cord-335975-m6lkrehi 2145 1 2600 2600 CD cord-335975-m6lkrehi 2145 2 µg µg NNP cord-335975-m6lkrehi 2145 3 kg kg NNP cord-335975-m6lkrehi 2145 4 at at IN cord-335975-m6lkrehi 2145 5 24 24 CD cord-335975-m6lkrehi 2145 6 h h NN cord-335975-m6lkrehi 2145 7 ) ) -RRB- cord-335975-m6lkrehi 2145 8 was be VBD cord-335975-m6lkrehi 2145 9 able able JJ cord-335975-m6lkrehi 2145 10 to to TO cord-335975-m6lkrehi 2145 11 predict predict VB cord-335975-m6lkrehi 2145 12 EDASS EDASS NNP cord-335975-m6lkrehi 2145 13 with with IN cord-335975-m6lkrehi 2145 14 sensitivity sensitivity NN cord-335975-m6lkrehi 2145 15 of of IN cord-335975-m6lkrehi 2145 16 45 45 CD cord-335975-m6lkrehi 2145 17 % % NN cord-335975-m6lkrehi 2145 18 , , , cord-335975-m6lkrehi 2145 19 specificity specificity NN cord-335975-m6lkrehi 2145 20 97 97 CD cord-335975-m6lkrehi 2145 21 % % NN cord-335975-m6lkrehi 2145 22 , , , cord-335975-m6lkrehi 2145 23 positive positive JJ cord-335975-m6lkrehi 2145 24 predictive predictive JJ cord-335975-m6lkrehi 2145 25 value value NN cord-335975-m6lkrehi 2145 26 78 78 CD cord-335975-m6lkrehi 2145 27 % % NN cord-335975-m6lkrehi 2145 28 and and CC cord-335975-m6lkrehi 2145 29 negative negative JJ cord-335975-m6lkrehi 2145 30 predictive predictive JJ cord-335975-m6lkrehi 2145 31 value value NN cord-335975-m6lkrehi 2145 32 94 94 CD cord-335975-m6lkrehi 2145 33 % % NN cord-335975-m6lkrehi 2145 34 . . . cord-335975-m6lkrehi 2146 1 Overall overall RB cord-335975-m6lkrehi 2146 2 , , , cord-335975-m6lkrehi 2146 3 this this DT cord-335975-m6lkrehi 2146 4 two two CD cord-335975-m6lkrehi 2146 5 - - HYPH cord-335975-m6lkrehi 2146 6 step step NN cord-335975-m6lkrehi 2146 7 strategy strategy NN cord-335975-m6lkrehi 2146 8 identified identify VBD cord-335975-m6lkrehi 2146 9 18 18 CD cord-335975-m6lkrehi 2146 10 high high JJ cord-335975-m6lkrehi 2146 11 - - HYPH cord-335975-m6lkrehi 2146 12 risk risk NN cord-335975-m6lkrehi 2146 13 patients patient NNS cord-335975-m6lkrehi 2146 14 at at IN cord-335975-m6lkrehi 2146 15 6 6 CD cord-335975-m6lkrehi 2146 16 h h NN cord-335975-m6lkrehi 2146 17 , , , cord-335975-m6lkrehi 2146 18 of of IN cord-335975-m6lkrehi 2146 19 whom whom WP cord-335975-m6lkrehi 2146 20 15 15 CD cord-335975-m6lkrehi 2146 21 presented present VBN cord-335975-m6lkrehi 2146 22 EDASS EDASS NNP cord-335975-m6lkrehi 2146 23 . . . cord-335975-m6lkrehi 2147 1 Conclusion conclusion NN cord-335975-m6lkrehi 2147 2 : : : cord-335975-m6lkrehi 2148 1 Overall overall RB cord-335975-m6lkrehi 2148 2 , , , cord-335975-m6lkrehi 2148 3 our -PRON- PRP$ cord-335975-m6lkrehi 2148 4 results result NNS cord-335975-m6lkrehi 2148 5 confirm confirm VBP cord-335975-m6lkrehi 2148 6 that that IN cord-335975-m6lkrehi 2148 7 early early JJ cord-335975-m6lkrehi 2148 8 death death NN cord-335975-m6lkrehi 2148 9 directly directly RB cord-335975-m6lkrehi 2148 10 attributable attributable JJ cord-335975-m6lkrehi 2148 11 to to IN cord-335975-m6lkrehi 2148 12 septic septic JJ cord-335975-m6lkrehi 2148 13 shock shock NN cord-335975-m6lkrehi 2148 14 could could MD cord-335975-m6lkrehi 2148 15 be be VB cord-335975-m6lkrehi 2148 16 effectively effectively RB cord-335975-m6lkrehi 2148 17 predicted predict VBN cord-335975-m6lkrehi 2148 18 by by IN cord-335975-m6lkrehi 2148 19 the the DT cord-335975-m6lkrehi 2148 20 CDV CDV NNP cord-335975-m6lkrehi 2148 21 in in IN cord-335975-m6lkrehi 2148 22 the the DT cord-335975-m6lkrehi 2148 23 first first JJ cord-335975-m6lkrehi 2148 24 hours hour NNS cord-335975-m6lkrehi 2148 25 of of IN cord-335975-m6lkrehi 2148 26 treatment treatment NN cord-335975-m6lkrehi 2148 27 . . . cord-335975-m6lkrehi 2149 1 These these DT cord-335975-m6lkrehi 2149 2 results result NNS cord-335975-m6lkrehi 2149 3 will will MD cord-335975-m6lkrehi 2149 4 help help VB cord-335975-m6lkrehi 2149 5 to to TO cord-335975-m6lkrehi 2149 6 select select VB cord-335975-m6lkrehi 2149 7 patients patient NNS cord-335975-m6lkrehi 2149 8 eligible eligible JJ cord-335975-m6lkrehi 2149 9 for for IN cord-335975-m6lkrehi 2149 10 innovative innovative JJ cord-335975-m6lkrehi 2149 11 therapies therapy NNS cord-335975-m6lkrehi 2149 12 aimed aim VBN cord-335975-m6lkrehi 2149 13 at at IN cord-335975-m6lkrehi 2149 14 improving improve VBG cord-335975-m6lkrehi 2149 15 early early JJ cord-335975-m6lkrehi 2149 16 mortality mortality NN cord-335975-m6lkrehi 2149 17 in in IN cord-335975-m6lkrehi 2149 18 septic septic JJ cord-335975-m6lkrehi 2149 19 shock shock NN cord-335975-m6lkrehi 2149 20 . . . cord-335975-m6lkrehi 2150 1 Introduction introduction NN cord-335975-m6lkrehi 2150 2 : : : cord-335975-m6lkrehi 2151 1 In in IN cord-335975-m6lkrehi 2151 2 patients patient NNS cord-335975-m6lkrehi 2151 3 with with IN cord-335975-m6lkrehi 2151 4 cardiac cardiac JJ cord-335975-m6lkrehi 2151 5 arrest arrest NN cord-335975-m6lkrehi 2151 6 , , , cord-335975-m6lkrehi 2151 7 end end NN cord-335975-m6lkrehi 2151 8 - - HYPH cord-335975-m6lkrehi 2151 9 tidal tidal JJ cord-335975-m6lkrehi 2151 10 CO2 co2 NN cord-335975-m6lkrehi 2151 11 ( ( -LRB- cord-335975-m6lkrehi 2151 12 EtCO2 etco2 NN cord-335975-m6lkrehi 2151 13 ) ) -RRB- cord-335975-m6lkrehi 2151 14 has have VBZ cord-335975-m6lkrehi 2151 15 been be VBN cord-335975-m6lkrehi 2151 16 proposed propose VBN cord-335975-m6lkrehi 2151 17 to to TO cord-335975-m6lkrehi 2151 18 monitor monitor VB cord-335975-m6lkrehi 2151 19 the the DT cord-335975-m6lkrehi 2151 20 efficacy efficacy NN cord-335975-m6lkrehi 2151 21 of of IN cord-335975-m6lkrehi 2151 22 cardiopulmonary cardiopulmonary JJ cord-335975-m6lkrehi 2151 23 resuscitation resuscitation NN cord-335975-m6lkrehi 2151 24 ( ( -LRB- cord-335975-m6lkrehi 2151 25 CPR CPR NNP cord-335975-m6lkrehi 2151 26 ) ) -RRB- cord-335975-m6lkrehi 2151 27 but but CC cord-335975-m6lkrehi 2151 28 uncertainty uncertainty NN cord-335975-m6lkrehi 2151 29 persists persist VBZ cord-335975-m6lkrehi 2151 30 on on IN cord-335975-m6lkrehi 2151 31 its -PRON- PRP$ cord-335975-m6lkrehi 2151 32 interpretation interpretation NN cord-335975-m6lkrehi 2151 33 . . . cord-335975-m6lkrehi 2152 1 We -PRON- PRP cord-335975-m6lkrehi 2152 2 hypothesized hypothesize VBD cord-335975-m6lkrehi 2152 3 that that IN cord-335975-m6lkrehi 2152 4 exhaled exhale VBN cord-335975-m6lkrehi 2152 5 CO2 CO2 NNP cord-335975-m6lkrehi 2152 6 may may MD cord-335975-m6lkrehi 2152 7 also also RB cord-335975-m6lkrehi 2152 8 by by IN cord-335975-m6lkrehi 2152 9 affected affect VBN cord-335975-m6lkrehi 2152 10 by by IN cord-335975-m6lkrehi 2152 11 occurrence occurrence NN cord-335975-m6lkrehi 2152 12 of of IN cord-335975-m6lkrehi 2152 13 " " `` cord-335975-m6lkrehi 2152 14 lung lung NNP cord-335975-m6lkrehi 2152 15 airways airways NNPS cord-335975-m6lkrehi 2152 16 " " '' cord-335975-m6lkrehi 2152 17 collapse collapse NN cord-335975-m6lkrehi 2152 18 previously previously RB cord-335975-m6lkrehi 2152 19 noticed notice VBD cord-335975-m6lkrehi 2152 20 during during IN cord-335975-m6lkrehi 2152 21 CPR CPR NNP cord-335975-m6lkrehi 2152 22 . . . cord-335975-m6lkrehi 2153 1 Because because IN cord-335975-m6lkrehi 2153 2 this this DT cord-335975-m6lkrehi 2153 3 closure closure NN cord-335975-m6lkrehi 2153 4 may may MD cord-335975-m6lkrehi 2153 5 possibly possibly RB cord-335975-m6lkrehi 2153 6 also also RB cord-335975-m6lkrehi 2153 7 limit limit VB cord-335975-m6lkrehi 2153 8 oxygenation oxygenation NN cord-335975-m6lkrehi 2153 9 + + CC cord-335975-m6lkrehi 2153 10 analysis analysis NN cord-335975-m6lkrehi 2153 11 of of IN cord-335975-m6lkrehi 2153 12 the the DT cord-335975-m6lkrehi 2153 13 entire entire JJ cord-335975-m6lkrehi 2153 14 exhaled exhale VBN cord-335975-m6lkrehi 2153 15 CO2 CO2 NNP cord-335975-m6lkrehi 2153 16 time time NN cord-335975-m6lkrehi 2153 17 waveform waveform NN cord-335975-m6lkrehi 2153 18 - - : cord-335975-m6lkrehi 2153 19 may may MD cord-335975-m6lkrehi 2153 20 give give VB cord-335975-m6lkrehi 2153 21 information information NN cord-335975-m6lkrehi 2153 22 of of IN cord-335975-m6lkrehi 2153 23 high high JJ cord-335975-m6lkrehi 2153 24 clinical clinical JJ cord-335975-m6lkrehi 2153 25 value value NN cord-335975-m6lkrehi 2153 26 to to TO cord-335975-m6lkrehi 2153 27 manage manage VB cord-335975-m6lkrehi 2153 28 CPR CPR NNP cord-335975-m6lkrehi 2153 29 . . . cord-335975-m6lkrehi 2154 1 We -PRON- PRP cord-335975-m6lkrehi 2154 2 report report VBP cord-335975-m6lkrehi 2154 3 preliminary preliminary JJ cord-335975-m6lkrehi 2154 4 results result NNS cord-335975-m6lkrehi 2154 5 from from IN cord-335975-m6lkrehi 2154 6 a a DT cord-335975-m6lkrehi 2154 7 clinical clinical JJ cord-335975-m6lkrehi 2154 8 and and CC cord-335975-m6lkrehi 2154 9 bench bench NN cord-335975-m6lkrehi 2154 10 study study NN cord-335975-m6lkrehi 2154 11 aimed aim VBN cord-335975-m6lkrehi 2154 12 at at IN cord-335975-m6lkrehi 2154 13 describing describe VBG cord-335975-m6lkrehi 2154 14 the the DT cord-335975-m6lkrehi 2154 15 pattern pattern NN cord-335975-m6lkrehi 2154 16 of of IN cord-335975-m6lkrehi 2154 17 the the DT cord-335975-m6lkrehi 2154 18 capnogram capnogram NNP cord-335975-m6lkrehi 2154 19 during during IN cord-335975-m6lkrehi 2154 20 CPR CPR NNP cord-335975-m6lkrehi 2154 21 . . . cord-335975-m6lkrehi 2155 1 induces induce VBZ cord-335975-m6lkrehi 2155 2 a a DT cord-335975-m6lkrehi 2155 3 systemic systemic JJ cord-335975-m6lkrehi 2155 4 inflammatory inflammatory JJ cord-335975-m6lkrehi 2155 5 response response NN cord-335975-m6lkrehi 2155 6 associated associate VBN cord-335975-m6lkrehi 2155 7 with with IN cord-335975-m6lkrehi 2155 8 an an DT cord-335975-m6lkrehi 2155 9 immune immune JJ cord-335975-m6lkrehi 2155 10 dysregulation dysregulation NN cord-335975-m6lkrehi 2155 11 and and CC cord-335975-m6lkrehi 2155 12 a a DT cord-335975-m6lkrehi 2155 13 significant significant JJ cord-335975-m6lkrehi 2155 14 pulmonary pulmonary JJ cord-335975-m6lkrehi 2155 15 dysfunction dysfunction NN cord-335975-m6lkrehi 2155 16 which which WDT cord-335975-m6lkrehi 2155 17 has have VBZ cord-335975-m6lkrehi 2155 18 been be VBN cord-335975-m6lkrehi 2155 19 well well RB cord-335975-m6lkrehi 2155 20 characterized characterize VBN cord-335975-m6lkrehi 2155 21 . . . cord-335975-m6lkrehi 2156 1 Surprisingly surprisingly RB cord-335975-m6lkrehi 2156 2 , , , cord-335975-m6lkrehi 2156 3 there there EX cord-335975-m6lkrehi 2156 4 are be VBP cord-335975-m6lkrehi 2156 5 only only RB cord-335975-m6lkrehi 2156 6 a a DT cord-335975-m6lkrehi 2156 7 few few JJ cord-335975-m6lkrehi 2156 8 data datum NNS cord-335975-m6lkrehi 2156 9 available available JJ cord-335975-m6lkrehi 2156 10 on on IN cord-335975-m6lkrehi 2156 11 immunological immunological JJ cord-335975-m6lkrehi 2156 12 changes change NNS cord-335975-m6lkrehi 2156 13 induced induce VBN cord-335975-m6lkrehi 2156 14 by by IN cord-335975-m6lkrehi 2156 15 ECLS ECLS NNP cord-335975-m6lkrehi 2156 16 . . . cord-335975-m6lkrehi 2157 1 We -PRON- PRP cord-335975-m6lkrehi 2157 2 believe believe VBP cord-335975-m6lkrehi 2157 3 that that IN cord-335975-m6lkrehi 2157 4 ECLS ECLS NNP cord-335975-m6lkrehi 2157 5 leads lead VBZ cord-335975-m6lkrehi 2157 6 to to IN cord-335975-m6lkrehi 2157 7 immune immune JJ cord-335975-m6lkrehi 2157 8 dysfunction dysfunction NN cord-335975-m6lkrehi 2157 9 that that WDT cord-335975-m6lkrehi 2157 10 could could MD cord-335975-m6lkrehi 2157 11 expose expose VB cord-335975-m6lkrehi 2157 12 patients patient NNS cord-335975-m6lkrehi 2157 13 to to IN cord-335975-m6lkrehi 2157 14 nosocomial nosocomial JJ cord-335975-m6lkrehi 2157 15 infections infection NNS cord-335975-m6lkrehi 2157 16 . . . cord-335975-m6lkrehi 2158 1 Patients patient NNS cord-335975-m6lkrehi 2158 2 and and CC cord-335975-m6lkrehi 2158 3 methods method NNS cord-335975-m6lkrehi 2158 4 : : : cord-335975-m6lkrehi 2158 5 A a DT cord-335975-m6lkrehi 2158 6 two two CD cord-335975-m6lkrehi 2158 7 - - HYPH cord-335975-m6lkrehi 2158 8 phase phase NN cord-335975-m6lkrehi 2158 9 study study NN cord-335975-m6lkrehi 2158 10 was be VBD cord-335975-m6lkrehi 2158 11 lead lead JJ cord-335975-m6lkrehi 2158 12 . . . cord-335975-m6lkrehi 2159 1 First first RB cord-335975-m6lkrehi 2159 2 we -PRON- PRP cord-335975-m6lkrehi 2159 3 analyzed analyze VBD cord-335975-m6lkrehi 2159 4 blood blood NN cord-335975-m6lkrehi 2159 5 cell cell NN cord-335975-m6lkrehi 2159 6 count count NN cord-335975-m6lkrehi 2159 7 with with IN cord-335975-m6lkrehi 2159 8 differential differential NN cord-335975-m6lkrehi 2159 9 ( ( -LRB- cord-335975-m6lkrehi 2159 10 including include VBG cord-335975-m6lkrehi 2159 11 lymphocyte lymphocyte NN cord-335975-m6lkrehi 2159 12 , , , cord-335975-m6lkrehi 2159 13 neutrophils neutrophil NNS cord-335975-m6lkrehi 2159 14 and and CC cord-335975-m6lkrehi 2159 15 monocyte monocyte NNP cord-335975-m6lkrehi 2159 16 counts count VBZ cord-335975-m6lkrehi 2159 17 ) ) -RRB- cord-335975-m6lkrehi 2159 18 in in IN cord-335975-m6lkrehi 2159 19 all all DT cord-335975-m6lkrehi 2159 20 patients patient NNS cord-335975-m6lkrehi 2159 21 who who WP cord-335975-m6lkrehi 2159 22 received receive VBD cord-335975-m6lkrehi 2159 23 ECLS ECLS NNP cord-335975-m6lkrehi 2159 24 in in IN cord-335975-m6lkrehi 2159 25 our -PRON- PRP$ cord-335975-m6lkrehi 2159 26 institution institution NN cord-335975-m6lkrehi 2159 27 from from IN cord-335975-m6lkrehi 2159 28 2014 2014 CD cord-335975-m6lkrehi 2159 29 to to IN cord-335975-m6lkrehi 2159 30 2017 2017 CD cord-335975-m6lkrehi 2159 31 within within IN cord-335975-m6lkrehi 2159 32 the the DT cord-335975-m6lkrehi 2159 33 first first JJ cord-335975-m6lkrehi 2159 34 week week NN cord-335975-m6lkrehi 2159 35 following follow VBG cord-335975-m6lkrehi 2159 36 ECLS ECLS NNP cord-335975-m6lkrehi 2159 37 initiation initiation NN cord-335975-m6lkrehi 2159 38 . . . cord-335975-m6lkrehi 2160 1 Secondly secondly RB cord-335975-m6lkrehi 2160 2 , , , cord-335975-m6lkrehi 2160 3 Monocytes monocyte NNS cord-335975-m6lkrehi 2160 4 , , , cord-335975-m6lkrehi 2160 5 granulocytes granulocyte NNS cord-335975-m6lkrehi 2160 6 , , , cord-335975-m6lkrehi 2160 7 dendritic dendritic JJ cord-335975-m6lkrehi 2160 8 cells cell NNS cord-335975-m6lkrehi 2160 9 and and CC cord-335975-m6lkrehi 2160 10 lymphocytes lymphocyte NNS cord-335975-m6lkrehi 2160 11 function function NN cord-335975-m6lkrehi 2160 12 were be VBD cord-335975-m6lkrehi 2160 13 assessed assess VBN cord-335975-m6lkrehi 2160 14 at at IN cord-335975-m6lkrehi 2160 15 day day NN cord-335975-m6lkrehi 2160 16 0 0 CD cord-335975-m6lkrehi 2160 17 , , , cord-335975-m6lkrehi 2160 18 day day NN cord-335975-m6lkrehi 2160 19 1 1 CD cord-335975-m6lkrehi 2160 20 and and CC cord-335975-m6lkrehi 2160 21 day day NN cord-335975-m6lkrehi 2160 22 3 3 CD cord-335975-m6lkrehi 2160 23 using use VBG cord-335975-m6lkrehi 2160 24 flow flow NN cord-335975-m6lkrehi 2160 25 cytometry cytometry NN cord-335975-m6lkrehi 2160 26 and and CC cord-335975-m6lkrehi 2160 27 functional functional JJ cord-335975-m6lkrehi 2160 28 tests test NNS cord-335975-m6lkrehi 2160 29 in in IN cord-335975-m6lkrehi 2160 30 patients patient NNS cord-335975-m6lkrehi 2160 31 receiving receive VBG cord-335975-m6lkrehi 2160 32 ECLS ECLS NNP cord-335975-m6lkrehi 2160 33 and and CC cord-335975-m6lkrehi 2160 34 compared compare VBN cord-335975-m6lkrehi 2160 35 to to IN cord-335975-m6lkrehi 2160 36 patients patient NNS cord-335975-m6lkrehi 2160 37 with with IN cord-335975-m6lkrehi 2160 38 cardiogenic cardiogenic JJ cord-335975-m6lkrehi 2160 39 shock shock NN cord-335975-m6lkrehi 2160 40 without without IN cord-335975-m6lkrehi 2160 41 ECLS ECLS NNP cord-335975-m6lkrehi 2160 42 . . . cord-335975-m6lkrehi 2161 1 Results result NNS cord-335975-m6lkrehi 2161 2 : : : cord-335975-m6lkrehi 2162 1 Among among IN cord-335975-m6lkrehi 2162 2 159 159 CD cord-335975-m6lkrehi 2162 3 patients patient NNS cord-335975-m6lkrehi 2162 4 with with IN cord-335975-m6lkrehi 2162 5 ELCS elc NNS cord-335975-m6lkrehi 2162 6 we -PRON- PRP cord-335975-m6lkrehi 2162 7 found find VBD cord-335975-m6lkrehi 2162 8 an an DT cord-335975-m6lkrehi 2162 9 early early JJ cord-335975-m6lkrehi 2162 10 and and CC cord-335975-m6lkrehi 2162 11 persistent persistent JJ cord-335975-m6lkrehi 2162 12 lymphopenia lymphopenia NNP cord-335975-m6lkrehi 2162 13 and and CC cord-335975-m6lkrehi 2162 14 a a DT cord-335975-m6lkrehi 2162 15 late late JJ cord-335975-m6lkrehi 2162 16 neutrophilia neutrophilia NNP cord-335975-m6lkrehi 2162 17 ( ( -LRB- cord-335975-m6lkrehi 2162 18 found find VBN cord-335975-m6lkrehi 2162 19 to to TO cord-335975-m6lkrehi 2162 20 be be VB cord-335975-m6lkrehi 2162 21 associated associate VBN cord-335975-m6lkrehi 2162 22 with with IN cord-335975-m6lkrehi 2162 23 poor poor JJ cord-335975-m6lkrehi 2162 24 outcome outcome NN cord-335975-m6lkrehi 2162 25 in in IN cord-335975-m6lkrehi 2162 26 critically critically RB cord-335975-m6lkrehi 2162 27 ill ill JJ cord-335975-m6lkrehi 2162 28 patients patient NNS cord-335975-m6lkrehi 2162 29 ) ) -RRB- cord-335975-m6lkrehi 2162 30 . . . cord-335975-m6lkrehi 2163 1 Compared compare VBN cord-335975-m6lkrehi 2163 2 to to TO cord-335975-m6lkrehi 2163 3 control control VB cord-335975-m6lkrehi 2163 4 ( ( -LRB- cord-335975-m6lkrehi 2163 5 n n NN cord-335975-m6lkrehi 2163 6 = = SYM cord-335975-m6lkrehi 2163 7 7 7 CD cord-335975-m6lkrehi 2163 8 ) ) -RRB- cord-335975-m6lkrehi 2163 9 , , , cord-335975-m6lkrehi 2163 10 we -PRON- PRP cord-335975-m6lkrehi 2163 11 found find VBD cord-335975-m6lkrehi 2163 12 in in IN cord-335975-m6lkrehi 2163 13 patients patient NNS cord-335975-m6lkrehi 2163 14 who who WP cord-335975-m6lkrehi 2163 15 received receive VBD cord-335975-m6lkrehi 2163 16 ECLS ECLS NNP cord-335975-m6lkrehi 2163 17 ( ( -LRB- cord-335975-m6lkrehi 2163 18 n n NN cord-335975-m6lkrehi 2163 19 = = SYM cord-335975-m6lkrehi 2163 20 6 6 CD cord-335975-m6lkrehi 2163 21 ) ) -RRB- cord-335975-m6lkrehi 2163 22 a a DT cord-335975-m6lkrehi 2163 23 significant significant JJ cord-335975-m6lkrehi 2163 24 increase increase NN cord-335975-m6lkrehi 2163 25 in in IN cord-335975-m6lkrehi 2163 26 immature immature JJ cord-335975-m6lkrehi 2163 27 granulocytes granulocyte NNS cord-335975-m6lkrehi 2163 28 ( ( -LRB- cord-335975-m6lkrehi 2163 29 104.107 104.107 CD cord-335975-m6lkrehi 2163 30 ± ± CD cord-335975-m6lkrehi 2163 31 47.106 47.106 CD cord-335975-m6lkrehi 2163 32 on on IN cord-335975-m6lkrehi 2163 33 day day NN cord-335975-m6lkrehi 2163 34 one one CD cord-335975-m6lkrehi 2163 35 versus versus IN cord-335975-m6lkrehi 2163 36 95.105 95.105 CD cord-335975-m6lkrehi 2164 1 ± ± NNP cord-335975-m6lkrehi 2164 2 96 96 CD cord-335975-m6lkrehi 2164 3 ± ± CD cord-335975-m6lkrehi 2164 4 105 105 CD cord-335975-m6lkrehi 2164 5 , , , cord-335975-m6lkrehi 2164 6 p p NN cord-335975-m6lkrehi 2164 7 = = SYM cord-335975-m6lkrehi 2164 8 0.01 0.01 CD cord-335975-m6lkrehi 2164 9 ) ) -RRB- cord-335975-m6lkrehi 2165 1 and and CC cord-335975-m6lkrehi 2165 2 lymphocytes lymphocyte VBZ cord-335975-m6lkrehi 2165 3 apoptosis apoptosis NN cord-335975-m6lkrehi 2165 4 . . . cord-335975-m6lkrehi 2166 1 ECLS ECLS NNP cord-335975-m6lkrehi 2166 2 induced induce VBD cord-335975-m6lkrehi 2166 3 changes change NNS cord-335975-m6lkrehi 2166 4 in in IN cord-335975-m6lkrehi 2166 5 Myeloid Myeloid NNP cord-335975-m6lkrehi 2166 6 derived derive VBN cord-335975-m6lkrehi 2166 7 suppressors suppressor NNS cord-335975-m6lkrehi 2166 8 cells cell NNS cord-335975-m6lkrehi 2166 9 proportion proportion NN cord-335975-m6lkrehi 2166 10 ( ( -LRB- cord-335975-m6lkrehi 2166 11 3.69 3.69 CD cord-335975-m6lkrehi 2166 12 % % NN cord-335975-m6lkrehi 2166 13 ± ± NNP cord-335975-m6lkrehi 2166 14 3.5 3.5 CD cord-335975-m6lkrehi 2166 15 on on IN cord-335975-m6lkrehi 2166 16 day day NN cord-335975-m6lkrehi 2166 17 three three CD cord-335975-m6lkrehi 2166 18 versus versus IN cord-335975-m6lkrehi 2166 19 0.58 0.58 CD cord-335975-m6lkrehi 2166 20 % % NN cord-335975-m6lkrehi 2166 21 ± ± CD cord-335975-m6lkrehi 2166 22 0.49 0.49 CD cord-335975-m6lkrehi 2166 23 before before IN cord-335975-m6lkrehi 2166 24 ECLS ECLS NNP cord-335975-m6lkrehi 2166 25 , , , cord-335975-m6lkrehi 2166 26 p p NN cord-335975-m6lkrehi 2166 27 = = SYM cord-335975-m6lkrehi 2166 28 0.05 0.05 CD cord-335975-m6lkrehi 2166 29 ) ) -RRB- cord-335975-m6lkrehi 2166 30 , , , cord-335975-m6lkrehi 2166 31 which which WDT cord-335975-m6lkrehi 2166 32 has have VBZ cord-335975-m6lkrehi 2166 33 been be VBN cord-335975-m6lkrehi 2166 34 recently recently RB cord-335975-m6lkrehi 2166 35 associated associate VBN cord-335975-m6lkrehi 2166 36 with with IN cord-335975-m6lkrehi 2166 37 a a DT cord-335975-m6lkrehi 2166 38 higher high JJR cord-335975-m6lkrehi 2166 39 incidence incidence NN cord-335975-m6lkrehi 2166 40 of of IN cord-335975-m6lkrehi 2166 41 nosocomial nosocomial JJ cord-335975-m6lkrehi 2166 42 infections infection NNS cord-335975-m6lkrehi 2166 43 and and CC cord-335975-m6lkrehi 2166 44 seems seem VBZ cord-335975-m6lkrehi 2166 45 to to TO cord-335975-m6lkrehi 2166 46 be be VB cord-335975-m6lkrehi 2166 47 major major JJ cord-335975-m6lkrehi 2166 48 actors actor NNS cord-335975-m6lkrehi 2166 49 of of IN cord-335975-m6lkrehi 2166 50 sepsis sepsis NN cord-335975-m6lkrehi 2166 51 - - HYPH cord-335975-m6lkrehi 2166 52 induced induce VBN cord-335975-m6lkrehi 2166 53 immune immune JJ cord-335975-m6lkrehi 2166 54 suppression suppression NN cord-335975-m6lkrehi 2166 55 . . . cord-335975-m6lkrehi 2167 1 Complement complement JJ cord-335975-m6lkrehi 2167 2 component component NN cord-335975-m6lkrehi 2167 3 5a 5a CD cord-335975-m6lkrehi 2167 4 receptor receptor NN cord-335975-m6lkrehi 2167 5 ( ( -LRB- cord-335975-m6lkrehi 2167 6 C5aR C5aR NNP cord-335975-m6lkrehi 2167 7 ) ) -RRB- cord-335975-m6lkrehi 2167 8 from from IN cord-335975-m6lkrehi 2167 9 the the DT cord-335975-m6lkrehi 2167 10 neutrophil neutrophil NN cord-335975-m6lkrehi 2167 11 cell cell NN cord-335975-m6lkrehi 2167 12 surface surface NN cord-335975-m6lkrehi 2167 13 , , , cord-335975-m6lkrehi 2167 14 was be VBD cord-335975-m6lkrehi 2167 15 also also RB cord-335975-m6lkrehi 2167 16 decreased decrease VBN cord-335975-m6lkrehi 2167 17 after after IN cord-335975-m6lkrehi 2167 18 ECLS ECLS NNP cord-335975-m6lkrehi 2167 19 initiation initiation NN cord-335975-m6lkrehi 2167 20 ( ( -LRB- cord-335975-m6lkrehi 2167 21 ratio ratio NN cord-335975-m6lkrehi 2167 22 of of IN cord-335975-m6lkrehi 2167 23 mean mean JJ cord-335975-m6lkrehi 2167 24 fluorescence fluorescence NN cord-335975-m6lkrehi 2167 25 index index NN cord-335975-m6lkrehi 2167 26 0.73 0.73 CD cord-335975-m6lkrehi 2167 27 ± ± CD cord-335975-m6lkrehi 2167 28 0.22 0.22 CD cord-335975-m6lkrehi 2167 29 on on IN cord-335975-m6lkrehi 2167 30 day day NN cord-335975-m6lkrehi 2167 31 one one CD cord-335975-m6lkrehi 2167 32 , , , cord-335975-m6lkrehi 2167 33 p p NN cord-335975-m6lkrehi 2167 34 = = SYM cord-335975-m6lkrehi 2167 35 0.03 0.03 CD cord-335975-m6lkrehi 2167 36 ) ) -RRB- cord-335975-m6lkrehi 2167 37 which which WDT cord-335975-m6lkrehi 2167 38 is be VBZ cord-335975-m6lkrehi 2167 39 a a DT cord-335975-m6lkrehi 2167 40 sign sign NN cord-335975-m6lkrehi 2167 41 of of IN cord-335975-m6lkrehi 2167 42 complement complement NN cord-335975-m6lkrehi 2167 43 - - HYPH cord-335975-m6lkrehi 2167 44 induced induce VBN cord-335975-m6lkrehi 2167 45 neutrophil neutrophil NN cord-335975-m6lkrehi 2167 46 dysfunction dysfunction NN cord-335975-m6lkrehi 2167 47 in in IN cord-335975-m6lkrehi 2167 48 septic septic JJ cord-335975-m6lkrehi 2167 49 patients patient NNS cord-335975-m6lkrehi 2167 50 . . . cord-335975-m6lkrehi 2168 1 Conclusion conclusion NN cord-335975-m6lkrehi 2168 2 : : : cord-335975-m6lkrehi 2169 1 ECLS ECLS NNP cord-335975-m6lkrehi 2169 2 induces induce VBZ cord-335975-m6lkrehi 2169 3 quantitative quantitative JJ cord-335975-m6lkrehi 2169 4 and and CC cord-335975-m6lkrehi 2169 5 qualitative qualitative JJ cord-335975-m6lkrehi 2169 6 leukocytes leukocyte NNS cord-335975-m6lkrehi 2169 7 dysfunctions dysfunction NNS cord-335975-m6lkrehi 2169 8 that that WDT cord-335975-m6lkrehi 2169 9 can can MD cord-335975-m6lkrehi 2169 10 lead lead VB cord-335975-m6lkrehi 2169 11 to to IN cord-335975-m6lkrehi 2169 12 a a DT cord-335975-m6lkrehi 2169 13 greater great JJR cord-335975-m6lkrehi 2169 14 susceptibility susceptibility NN cord-335975-m6lkrehi 2169 15 to to IN cord-335975-m6lkrehi 2169 16 nosocomial nosocomial JJ cord-335975-m6lkrehi 2169 17 infections infection NNS cord-335975-m6lkrehi 2169 18 which which WDT cord-335975-m6lkrehi 2169 19 contribute contribute VBP cord-335975-m6lkrehi 2169 20 to to IN cord-335975-m6lkrehi 2169 21 the the DT cord-335975-m6lkrehi 2169 22 poor poor JJ cord-335975-m6lkrehi 2169 23 outcome outcome NN cord-335975-m6lkrehi 2169 24 observed observe VBN cord-335975-m6lkrehi 2169 25 in in IN cord-335975-m6lkrehi 2169 26 several several JJ cord-335975-m6lkrehi 2169 27 studies study NNS cord-335975-m6lkrehi 2169 28 . . . cord-335975-m6lkrehi 2170 1 Introduction introduction NN cord-335975-m6lkrehi 2170 2 : : : cord-335975-m6lkrehi 2171 1 Aspiration Aspiration NNP cord-335975-m6lkrehi 2171 2 pneumonia pneumonia NN cord-335975-m6lkrehi 2171 3 is be VBZ cord-335975-m6lkrehi 2171 4 a a DT cord-335975-m6lkrehi 2171 5 common common JJ cord-335975-m6lkrehi 2171 6 complication complication NN cord-335975-m6lkrehi 2171 7 of of IN cord-335975-m6lkrehi 2171 8 cardiac cardiac JJ cord-335975-m6lkrehi 2171 9 arrest arrest NN cord-335975-m6lkrehi 2171 10 . . . cord-335975-m6lkrehi 2172 1 Although although IN cord-335975-m6lkrehi 2172 2 its -PRON- PRP$ cord-335975-m6lkrehi 2172 3 real real JJ cord-335975-m6lkrehi 2172 4 incidence incidence NN cord-335975-m6lkrehi 2172 5 remains remain VBZ cord-335975-m6lkrehi 2172 6 undetermined undetermined JJ cord-335975-m6lkrehi 2172 7 , , , cord-335975-m6lkrehi 2172 8 probabilist probabilist NN cord-335975-m6lkrehi 2172 9 antibiotherapy antibiotherapy NNP cord-335975-m6lkrehi 2172 10 is be VBZ cord-335975-m6lkrehi 2172 11 frequently frequently RB cord-335975-m6lkrehi 2172 12 or or CC cord-335975-m6lkrehi 2172 13 even even RB cord-335975-m6lkrehi 2172 14 systematically systematically RB cord-335975-m6lkrehi 2172 15 prescribed prescribe VBN cord-335975-m6lkrehi 2172 16 in in IN cord-335975-m6lkrehi 2172 17 these these DT cord-335975-m6lkrehi 2172 18 cases case NNS cord-335975-m6lkrehi 2172 19 . . . cord-335975-m6lkrehi 2173 1 We -PRON- PRP cord-335975-m6lkrehi 2173 2 assessed assess VBD cord-335975-m6lkrehi 2173 3 the the DT cord-335975-m6lkrehi 2173 4 incidence incidence NN cord-335975-m6lkrehi 2173 5 of of IN cord-335975-m6lkrehi 2173 6 out out IN cord-335975-m6lkrehi 2173 7 - - HYPH cord-335975-m6lkrehi 2173 8 of of IN cord-335975-m6lkrehi 2173 9 - - HYPH cord-335975-m6lkrehi 2173 10 hospital hospital NN cord-335975-m6lkrehi 2173 11 cardiac cardiac JJ cord-335975-m6lkrehi 2173 12 arrest arrest NN cord-335975-m6lkrehi 2173 13 - - HYPH cord-335975-m6lkrehi 2173 14 related relate VBN cord-335975-m6lkrehi 2173 15 aspiration aspiration NN cord-335975-m6lkrehi 2173 16 pneumonia pneumonia NN cord-335975-m6lkrehi 2173 17 and and CC cord-335975-m6lkrehi 2173 18 the the DT cord-335975-m6lkrehi 2173 19 impact impact NN cord-335975-m6lkrehi 2173 20 of of IN cord-335975-m6lkrehi 2173 21 a a DT cord-335975-m6lkrehi 2173 22 microbiological microbiological JJ cord-335975-m6lkrehi 2173 23 documentation documentation NN cord-335975-m6lkrehi 2173 24 in in IN cord-335975-m6lkrehi 2173 25 regard regard NN cord-335975-m6lkrehi 2173 26 to to IN cord-335975-m6lkrehi 2173 27 antibiotherapy antibiotherapy NNP cord-335975-m6lkrehi 2173 28 course course NN cord-335975-m6lkrehi 2173 29 . . . cord-335975-m6lkrehi 2174 1 Patients patient NNS cord-335975-m6lkrehi 2174 2 and and CC cord-335975-m6lkrehi 2174 3 methods method NNS cord-335975-m6lkrehi 2174 4 : : : cord-335975-m6lkrehi 2174 5 All all DT cord-335975-m6lkrehi 2174 6 patients patient NNS cord-335975-m6lkrehi 2174 7 admitted admit VBD cord-335975-m6lkrehi 2174 8 for for IN cord-335975-m6lkrehi 2174 9 out out IN cord-335975-m6lkrehi 2174 10 - - HYPH cord-335975-m6lkrehi 2174 11 of of IN cord-335975-m6lkrehi 2174 12 - - HYPH cord-335975-m6lkrehi 2174 13 hospital hospital NN cord-335975-m6lkrehi 2174 14 cardiac cardiac JJ cord-335975-m6lkrehi 2174 15 arrest arrest NN cord-335975-m6lkrehi 2174 16 from from IN cord-335975-m6lkrehi 2174 17 1 1 CD cord-335975-m6lkrehi 2174 18 1 1 CD cord-335975-m6lkrehi 2174 19 2014 2014 CD cord-335975-m6lkrehi 2174 20 to to IN cord-335975-m6lkrehi 2174 21 1 1 CD cord-335975-m6lkrehi 2174 22 8 8 CD cord-335975-m6lkrehi 2174 23 2017 2017 CD cord-335975-m6lkrehi 2174 24 were be VBD cord-335975-m6lkrehi 2174 25 studied study VBN cord-335975-m6lkrehi 2174 26 . . . cord-335975-m6lkrehi 2175 1 In in IN cord-335975-m6lkrehi 2175 2 our -PRON- PRP$ cord-335975-m6lkrehi 2175 3 ICU ICU NNP cord-335975-m6lkrehi 2175 4 , , , cord-335975-m6lkrehi 2175 5 aspiration aspiration NN cord-335975-m6lkrehi 2175 6 pneumonia pneumonia NN cord-335975-m6lkrehi 2175 7 is be VBZ cord-335975-m6lkrehi 2175 8 suspected suspect VBN cord-335975-m6lkrehi 2175 9 when when WRB cord-335975-m6lkrehi 2175 10 a a DT cord-335975-m6lkrehi 2175 11 clinical clinical JJ cord-335975-m6lkrehi 2175 12 syndrome syndrome NN cord-335975-m6lkrehi 2175 13 ( ( -LRB- cord-335975-m6lkrehi 2175 14 fever fever NN cord-335975-m6lkrehi 2175 15 , , , cord-335975-m6lkrehi 2175 16 per per IN cord-335975-m6lkrehi 2175 17 resuscitation resuscitation NN cord-335975-m6lkrehi 2175 18 constatation constatation NN cord-335975-m6lkrehi 2175 19 ) ) -RRB- cord-335975-m6lkrehi 2175 20 and and CC cord-335975-m6lkrehi 2175 21 or or CC cord-335975-m6lkrehi 2175 22 chest chest NN cord-335975-m6lkrehi 2175 23 radiography radiography NN cord-335975-m6lkrehi 2175 24 infiltrates infiltrate NNS cord-335975-m6lkrehi 2175 25 were be VBD cord-335975-m6lkrehi 2175 26 present present JJ cord-335975-m6lkrehi 2175 27 . . . cord-335975-m6lkrehi 2176 1 In in IN cord-335975-m6lkrehi 2176 2 case case NN cord-335975-m6lkrehi 2176 3 of of IN cord-335975-m6lkrehi 2176 4 suspected suspect VBN cord-335975-m6lkrehi 2176 5 aspiration aspiration NN cord-335975-m6lkrehi 2176 6 pneumonia pneumonia NN cord-335975-m6lkrehi 2176 7 , , , cord-335975-m6lkrehi 2176 8 a a DT cord-335975-m6lkrehi 2176 9 microbiological microbiological JJ cord-335975-m6lkrehi 2176 10 documentation documentation NN cord-335975-m6lkrehi 2176 11 was be VBD cord-335975-m6lkrehi 2176 12 performed perform VBN cord-335975-m6lkrehi 2176 13 before before IN cord-335975-m6lkrehi 2176 14 initiation initiation NN cord-335975-m6lkrehi 2176 15 of of IN cord-335975-m6lkrehi 2176 16 probabilist probabilist NN cord-335975-m6lkrehi 2176 17 treatment treatment NN cord-335975-m6lkrehi 2176 18 with with IN cord-335975-m6lkrehi 2176 19 amoxicillin amoxicillin NNP cord-335975-m6lkrehi 2176 20 - - HYPH cord-335975-m6lkrehi 2176 21 clavulanate clavulanate NNP cord-335975-m6lkrehi 2176 22 . . . cord-335975-m6lkrehi 2177 1 We -PRON- PRP cord-335975-m6lkrehi 2177 2 retrospectively retrospectively RB cord-335975-m6lkrehi 2177 3 defined define VBD cord-335975-m6lkrehi 2177 4 if if IN cord-335975-m6lkrehi 2177 5 patients patient NNS cord-335975-m6lkrehi 2177 6 have have VBP cord-335975-m6lkrehi 2177 7 aspiration aspiration NN cord-335975-m6lkrehi 2177 8 pneumonia pneumonia NN cord-335975-m6lkrehi 2177 9 using use VBG cord-335975-m6lkrehi 2177 10 the the DT cord-335975-m6lkrehi 2177 11 following follow VBG cord-335975-m6lkrehi 2177 12 criteria criterion NNS cord-335975-m6lkrehi 2177 13 - - HYPH cord-335975-m6lkrehi 2177 14 per per RP cord-335975-m6lkrehi 2177 15 resuscitation resuscitation NN cord-335975-m6lkrehi 2177 16 constatation constatation NN cord-335975-m6lkrehi 2177 17 , , , cord-335975-m6lkrehi 2177 18 chest chest NN cord-335975-m6lkrehi 2177 19 radiography radiography NN cord-335975-m6lkrehi 2177 20 infiltrates infiltrate VBZ cord-335975-m6lkrehi 2177 21 , , , cord-335975-m6lkrehi 2177 22 fever fever NN cord-335975-m6lkrehi 2177 23 . . . cord-335975-m6lkrehi 2178 1 The the DT cord-335975-m6lkrehi 2178 2 number number NN cord-335975-m6lkrehi 2178 3 of of IN cord-335975-m6lkrehi 2178 4 microbiological microbiological JJ cord-335975-m6lkrehi 2178 5 documentation documentation NN cord-335975-m6lkrehi 2178 6 leading lead VBG cord-335975-m6lkrehi 2178 7 to to IN cord-335975-m6lkrehi 2178 8 an an DT cord-335975-m6lkrehi 2178 9 antibiotherapy antibiotherapy JJ cord-335975-m6lkrehi 2178 10 modification modification NN cord-335975-m6lkrehi 2178 11 was be VBD cord-335975-m6lkrehi 2178 12 recorded record VBN cord-335975-m6lkrehi 2178 13 as as RB cord-335975-m6lkrehi 2178 14 well well RB cord-335975-m6lkrehi 2178 15 as as IN cord-335975-m6lkrehi 2178 16 pathogens pathogen NNS cord-335975-m6lkrehi 2178 17 types type NNS cord-335975-m6lkrehi 2178 18 . . . cord-335975-m6lkrehi 2179 1 Data datum NNS cord-335975-m6lkrehi 2179 2 are be VBP cord-335975-m6lkrehi 2179 3 expressed express VBN cord-335975-m6lkrehi 2179 4 as as IN cord-335975-m6lkrehi 2179 5 numbers number NNS cord-335975-m6lkrehi 2179 6 ( ( -LRB- cord-335975-m6lkrehi 2179 7 % % NN cord-335975-m6lkrehi 2179 8 ) ) -RRB- cord-335975-m6lkrehi 2179 9 and and CC cord-335975-m6lkrehi 2179 10 medians median NNS cord-335975-m6lkrehi 2179 11 ( ( -LRB- cord-335975-m6lkrehi 2179 12 interquartile interquartile JJ cord-335975-m6lkrehi 2179 13 range range NN cord-335975-m6lkrehi 2179 14 ) ) -RRB- cord-335975-m6lkrehi 2179 15 . . . cord-335975-m6lkrehi 2180 1 Statistical statistical JJ cord-335975-m6lkrehi 2180 2 analysis analysis NN cord-335975-m6lkrehi 2180 3 was be VBD cord-335975-m6lkrehi 2180 4 made make VBN cord-335975-m6lkrehi 2180 5 as as IN cord-335975-m6lkrehi 2180 6 appropriate appropriate JJ cord-335975-m6lkrehi 2180 7 using use VBG cord-335975-m6lkrehi 2180 8 the the DT cord-335975-m6lkrehi 2180 9 XLSTAT xlstat NN cord-335975-m6lkrehi 2180 10 software software NN cord-335975-m6lkrehi 2180 11 . . . cord-335975-m6lkrehi 2181 1 Results result NNS cord-335975-m6lkrehi 2181 2 : : : cord-335975-m6lkrehi 2182 1 176 176 CD cord-335975-m6lkrehi 2182 2 patients patient NNS cord-335975-m6lkrehi 2182 3 were be VBD cord-335975-m6lkrehi 2182 4 studied study VBN cord-335975-m6lkrehi 2182 5 . . . cord-335975-m6lkrehi 2183 1 Clinical clinical JJ cord-335975-m6lkrehi 2183 2 characteristics characteristic NNS cord-335975-m6lkrehi 2183 3 are be VBP cord-335975-m6lkrehi 2183 4 displayed display VBN cord-335975-m6lkrehi 2183 5 in in IN cord-335975-m6lkrehi 2183 6 Table Table NNP cord-335975-m6lkrehi 2183 7 1 1 CD cord-335975-m6lkrehi 2183 8 . . . cord-335975-m6lkrehi 2184 1 80 80 CD cord-335975-m6lkrehi 2184 2 ( ( -LRB- cord-335975-m6lkrehi 2184 3 45 45 CD cord-335975-m6lkrehi 2184 4 ) ) -RRB- cord-335975-m6lkrehi 2184 5 received receive VBD cord-335975-m6lkrehi 2184 6 a a DT cord-335975-m6lkrehi 2184 7 probabilist probabilist NN cord-335975-m6lkrehi 2184 8 antibiotherapy antibiotherapy NN cord-335975-m6lkrehi 2184 9 and and CC cord-335975-m6lkrehi 2184 10 79 79 CD cord-335975-m6lkrehi 2184 11 ( ( -LRB- cord-335975-m6lkrehi 2184 12 45 45 CD cord-335975-m6lkrehi 2184 13 ) ) -RRB- cord-335975-m6lkrehi 2184 14 were be VBD cord-335975-m6lkrehi 2184 15 retrospectively retrospectively RB cord-335975-m6lkrehi 2184 16 considered consider VBN cord-335975-m6lkrehi 2184 17 with with IN cord-335975-m6lkrehi 2184 18 aspiration aspiration NN cord-335975-m6lkrehi 2184 19 pneumonitia pneumonitia NN cord-335975-m6lkrehi 2184 20 . . . cord-335975-m6lkrehi 2185 1 Results result NNS cord-335975-m6lkrehi 2185 2 of of IN cord-335975-m6lkrehi 2185 3 microbiological microbiological JJ cord-335975-m6lkrehi 2185 4 documentation documentation NN cord-335975-m6lkrehi 2185 5 were be VBD cord-335975-m6lkrehi 2185 6 94 94 CD cord-335975-m6lkrehi 2185 7 ( ( -LRB- cord-335975-m6lkrehi 2185 8 53 53 CD cord-335975-m6lkrehi 2185 9 ) ) -RRB- cord-335975-m6lkrehi 2185 10 positive positive JJ cord-335975-m6lkrehi 2185 11 microbiological microbiological JJ cord-335975-m6lkrehi 2185 12 sample sample NN cord-335975-m6lkrehi 2185 13 and and CC cord-335975-m6lkrehi 2185 14 68 68 CD cord-335975-m6lkrehi 2185 15 ( ( -LRB- cord-335975-m6lkrehi 2185 16 38 38 CD cord-335975-m6lkrehi 2185 17 ) ) -RRB- cord-335975-m6lkrehi 2185 18 with with IN cord-335975-m6lkrehi 2185 19 a a DT cord-335975-m6lkrehi 2185 20 positive positive JJ cord-335975-m6lkrehi 2185 21 threshold threshold NN cord-335975-m6lkrehi 2185 22 whose whose WP$ cord-335975-m6lkrehi 2185 23 6 6 CD cord-335975-m6lkrehi 2185 24 ( ( -LRB- cord-335975-m6lkrehi 2185 25 3 3 CD cord-335975-m6lkrehi 2185 26 ) ) -RRB- cord-335975-m6lkrehi 2185 27 were be VBD cord-335975-m6lkrehi 2185 28 considered consider VBN cord-335975-m6lkrehi 2185 29 colonized colonize VBN cord-335975-m6lkrehi 2185 30 ( ( -LRB- cord-335975-m6lkrehi 2185 31 i.e. i.e. FW cord-335975-m6lkrehi 2185 32 no no DT cord-335975-m6lkrehi 2185 33 clinico clinico NN cord-335975-m6lkrehi 2185 34 - - HYPH cord-335975-m6lkrehi 2185 35 radiological radiological JJ cord-335975-m6lkrehi 2185 36 sign sign NN cord-335975-m6lkrehi 2185 37 ) ) -RRB- cord-335975-m6lkrehi 2185 38 . . . cord-335975-m6lkrehi 2186 1 On on IN cord-335975-m6lkrehi 2186 2 the the DT cord-335975-m6lkrehi 2186 3 entire entire JJ cord-335975-m6lkrehi 2186 4 positive positive JJ cord-335975-m6lkrehi 2186 5 culture culture NN cord-335975-m6lkrehi 2186 6 sample sample NN cord-335975-m6lkrehi 2186 7 , , , cord-335975-m6lkrehi 2186 8 51 51 CD cord-335975-m6lkrehi 2186 9 ( ( -LRB- cord-335975-m6lkrehi 2186 10 54 54 CD cord-335975-m6lkrehi 2186 11 ) ) -RRB- cord-335975-m6lkrehi 2186 12 were be VBD cord-335975-m6lkrehi 2186 13 positive positive JJ cord-335975-m6lkrehi 2186 14 with with IN cord-335975-m6lkrehi 2186 15 oropharyngeal oropharyngeal JJ cord-335975-m6lkrehi 2186 16 flora flora NNS cord-335975-m6lkrehi 2186 17 as as IN cord-335975-m6lkrehi 2186 18 unique unique JJ cord-335975-m6lkrehi 2186 19 pathogen pathogen NN cord-335975-m6lkrehi 2186 20 , , , cord-335975-m6lkrehi 2186 21 14 14 CD cord-335975-m6lkrehi 2186 22 ( ( -LRB- cord-335975-m6lkrehi 2186 23 15 15 CD cord-335975-m6lkrehi 2186 24 ) ) -RRB- cord-335975-m6lkrehi 2186 25 Introduction introduction NN cord-335975-m6lkrehi 2186 26 : : : cord-335975-m6lkrehi 2187 1 This this DT cord-335975-m6lkrehi 2187 2 study study NN cord-335975-m6lkrehi 2187 3 aimed aim VBD cord-335975-m6lkrehi 2187 4 to to TO cord-335975-m6lkrehi 2187 5 assess assess VB cord-335975-m6lkrehi 2187 6 whether whether IN cord-335975-m6lkrehi 2187 7 augmented augment VBN cord-335975-m6lkrehi 2187 8 renal renal JJ cord-335975-m6lkrehi 2187 9 clearance clearance NN cord-335975-m6lkrehi 2187 10 ( ( -LRB- cord-335975-m6lkrehi 2187 11 ARC ARC NNP cord-335975-m6lkrehi 2187 12 ) ) -RRB- cord-335975-m6lkrehi 2187 13 impacts impact NNS cord-335975-m6lkrehi 2187 14 negatively negatively RB cord-335975-m6lkrehi 2187 15 on on IN cord-335975-m6lkrehi 2187 16 piperacillin piperacillin NNP cord-335975-m6lkrehi 2187 17 - - HYPH cord-335975-m6lkrehi 2187 18 tazobactam tazobactam NNS cord-335975-m6lkrehi 2187 19 pharmacokinetic pharmacokinetic JJ cord-335975-m6lkrehi 2187 20 pharmacodynamics pharmacodynamic NNS cord-335975-m6lkrehi 2187 21 ( ( -LRB- cord-335975-m6lkrehi 2187 22 PK PK NNP cord-335975-m6lkrehi 2187 23 PD PD NNP cord-335975-m6lkrehi 2187 24 ) ) -RRB- cord-335975-m6lkrehi 2187 25 target target NN cord-335975-m6lkrehi 2187 26 attainment attainment JJ cord-335975-m6lkrehi 2187 27 in in IN cord-335975-m6lkrehi 2187 28 critically critically RB cord-335975-m6lkrehi 2187 29 ill ill JJ cord-335975-m6lkrehi 2187 30 patients patient NNS cord-335975-m6lkrehi 2187 31 receiving receive VBG cord-335975-m6lkrehi 2187 32 16 16 CD cord-335975-m6lkrehi 2187 33 g g NNP cord-335975-m6lkrehi 2187 34 day day NN cord-335975-m6lkrehi 2187 35 by by IN cord-335975-m6lkrehi 2187 36 continuous continuous JJ cord-335975-m6lkrehi 2187 37 infusion infusion NN cord-335975-m6lkrehi 2187 38 . . . cord-335975-m6lkrehi 2188 1 Patients patient NNS cord-335975-m6lkrehi 2188 2 and and CC cord-335975-m6lkrehi 2188 3 methods method NNS cord-335975-m6lkrehi 2188 4 : : : cord-335975-m6lkrehi 2188 5 Over over IN cord-335975-m6lkrehi 2188 6 an an DT cord-335975-m6lkrehi 2188 7 8-month 8-month JJ cord-335975-m6lkrehi 2188 8 period period NN cord-335975-m6lkrehi 2188 9 , , , cord-335975-m6lkrehi 2188 10 all all DT cord-335975-m6lkrehi 2188 11 critically critically RB cord-335975-m6lkrehi 2188 12 ill ill JJ cord-335975-m6lkrehi 2188 13 patients patient NNS cord-335975-m6lkrehi 2188 14 treated treat VBN cord-335975-m6lkrehi 2188 15 by by IN cord-335975-m6lkrehi 2188 16 piperacillin piperacillin NNP cord-335975-m6lkrehi 2188 17 - - HYPH cord-335975-m6lkrehi 2188 18 tazobactam tazobactam NNS cord-335975-m6lkrehi 2188 19 for for IN cord-335975-m6lkrehi 2188 20 a a DT cord-335975-m6lkrehi 2188 21 suspected suspect VBN cord-335975-m6lkrehi 2188 22 or or CC cord-335975-m6lkrehi 2188 23 documented document VBN cord-335975-m6lkrehi 2188 24 sepsis sepsis NN cord-335975-m6lkrehi 2188 25 without without IN cord-335975-m6lkrehi 2188 26 renal renal JJ cord-335975-m6lkrehi 2188 27 impairment impairment NN cord-335975-m6lkrehi 2188 28 were be VBD cord-335975-m6lkrehi 2188 29 eligible eligible JJ cord-335975-m6lkrehi 2188 30 . . . cord-335975-m6lkrehi 2189 1 During during IN cord-335975-m6lkrehi 2189 2 the the DT cord-335975-m6lkrehi 2189 3 first first JJ cord-335975-m6lkrehi 2189 4 three three CD cord-335975-m6lkrehi 2189 5 days day NNS cord-335975-m6lkrehi 2189 6 of of IN cord-335975-m6lkrehi 2189 7 antimicrobial antimicrobial JJ cord-335975-m6lkrehi 2189 8 therapy therapy NN cord-335975-m6lkrehi 2189 9 , , , cord-335975-m6lkrehi 2189 10 every every DT cord-335975-m6lkrehi 2189 11 patient patient NN cord-335975-m6lkrehi 2189 12 underwent undergo VBD cord-335975-m6lkrehi 2189 13 24-hour 24-hour JJ cord-335975-m6lkrehi 2189 14 creatinine creatinine NN cord-335975-m6lkrehi 2189 15 clearance clearance NN cord-335975-m6lkrehi 2189 16 ( ( -LRB- cord-335975-m6lkrehi 2189 17 CrCL CrCL NNP cord-335975-m6lkrehi 2189 18 ) ) -RRB- cord-335975-m6lkrehi 2189 19 measurements measurement NNS cord-335975-m6lkrehi 2189 20 and and CC cord-335975-m6lkrehi 2189 21 therapeutic therapeutic JJ cord-335975-m6lkrehi 2189 22 drug drug NN cord-335975-m6lkrehi 2189 23 monitoring monitoring NN cord-335975-m6lkrehi 2189 24 at at IN cord-335975-m6lkrehi 2189 25 steady steady JJ cord-335975-m6lkrehi 2189 26 state state NN cord-335975-m6lkrehi 2189 27 . . . cord-335975-m6lkrehi 2190 1 The the DT cord-335975-m6lkrehi 2190 2 main main JJ cord-335975-m6lkrehi 2190 3 PK PK NNP cord-335975-m6lkrehi 2190 4 PD PD NNP cord-335975-m6lkrehi 2190 5 outcome outcome NN cord-335975-m6lkrehi 2190 6 investigated investigate VBN cord-335975-m6lkrehi 2190 7 in in IN cord-335975-m6lkrehi 2190 8 this this DT cord-335975-m6lkrehi 2190 9 study study NN cord-335975-m6lkrehi 2190 10 was be VBD cord-335975-m6lkrehi 2190 11 the the DT cord-335975-m6lkrehi 2190 12 rate rate NN cord-335975-m6lkrehi 2190 13 of of IN cord-335975-m6lkrehi 2190 14 empirical empirical JJ cord-335975-m6lkrehi 2190 15 target target NN cord-335975-m6lkrehi 2190 16 non non JJ cord-335975-m6lkrehi 2190 17 - - JJ cord-335975-m6lkrehi 2190 18 attainment attainment JJ cord-335975-m6lkrehi 2190 19 using use VBG cord-335975-m6lkrehi 2190 20 a a DT cord-335975-m6lkrehi 2190 21 theoretical theoretical JJ cord-335975-m6lkrehi 2190 22 target target NN cord-335975-m6lkrehi 2190 23 MIC mic NN cord-335975-m6lkrehi 2190 24 of of IN cord-335975-m6lkrehi 2190 25 16 16 CD cord-335975-m6lkrehi 2190 26 mg mg NNP cord-335975-m6lkrehi 2190 27 L L NNP cord-335975-m6lkrehi 2190 28 −1 −1 NNP cord-335975-m6lkrehi 2190 29 for for IN cord-335975-m6lkrehi 2190 30 piperacillin piperacillin NN cord-335975-m6lkrehi 2190 31 and and CC cord-335975-m6lkrehi 2191 1 2 2 LS cord-335975-m6lkrehi 2191 2 mg mg NNP cord-335975-m6lkrehi 2191 3 L L NNP cord-335975-m6lkrehi 2191 4 −1 −1 NNP cord-335975-m6lkrehi 2191 5 for for IN cord-335975-m6lkrehi 2191 6 tazobactam tazobactam NNS cord-335975-m6lkrehi 2191 7 . . . cord-335975-m6lkrehi 2192 1 The the DT cord-335975-m6lkrehi 2192 2 secondary secondary JJ cord-335975-m6lkrehi 2192 3 clinical clinical JJ cord-335975-m6lkrehi 2192 4 outcome outcome NN cord-335975-m6lkrehi 2192 5 was be VBD cord-335975-m6lkrehi 2192 6 the the DT cord-335975-m6lkrehi 2192 7 rate rate NN cord-335975-m6lkrehi 2192 8 of of IN cord-335975-m6lkrehi 2192 9 therapeutic therapeutic JJ cord-335975-m6lkrehi 2192 10 failure failure NN cord-335975-m6lkrehi 2192 11 in in IN cord-335975-m6lkrehi 2192 12 microbiologically microbiologically RB cord-335975-m6lkrehi 2192 13 documented document VBN cord-335975-m6lkrehi 2192 14 infections infection NNS cord-335975-m6lkrehi 2192 15 , , , cord-335975-m6lkrehi 2192 16 defined define VBN cord-335975-m6lkrehi 2192 17 as as IN cord-335975-m6lkrehi 2192 18 an an DT cord-335975-m6lkrehi 2192 19 impaired impaired JJ cord-335975-m6lkrehi 2192 20 clinical clinical JJ cord-335975-m6lkrehi 2192 21 response response NN cord-335975-m6lkrehi 2192 22 with with IN cord-335975-m6lkrehi 2192 23 a a DT cord-335975-m6lkrehi 2192 24 need need NN cord-335975-m6lkrehi 2192 25 for for IN cord-335975-m6lkrehi 2192 26 escalating escalate VBG cord-335975-m6lkrehi 2192 27 antibiotics antibiotic NNS cord-335975-m6lkrehi 2192 28 during during IN cord-335975-m6lkrehi 2192 29 treatment treatment NN cord-335975-m6lkrehi 2192 30 and and CC cord-335975-m6lkrehi 2192 31 or or CC cord-335975-m6lkrehi 2192 32 within within IN cord-335975-m6lkrehi 2192 33 15 15 CD cord-335975-m6lkrehi 2192 34 days day NNS cord-335975-m6lkrehi 2192 35 after after IN cord-335975-m6lkrehi 2192 36 end end NN cord-335975-m6lkrehi 2192 37 - - HYPH cord-335975-m6lkrehi 2192 38 of of IN cord-335975-m6lkrehi 2192 39 - - HYPH cord-335975-m6lkrehi 2192 40 treatment treatment NN cord-335975-m6lkrehi 2192 41 . . . cord-335975-m6lkrehi 2193 1 Over over IN cord-335975-m6lkrehi 2193 2 the the DT cord-335975-m6lkrehi 2193 3 study study NN cord-335975-m6lkrehi 2193 4 period period NN cord-335975-m6lkrehi 2193 5 , , , cord-335975-m6lkrehi 2193 6 60 60 CD cord-335975-m6lkrehi 2193 7 patients patient NNS cord-335975-m6lkrehi 2193 8 were be VBD cord-335975-m6lkrehi 2193 9 included include VBN cord-335975-m6lkrehi 2193 10 in in IN cord-335975-m6lkrehi 2193 11 the the DT cord-335975-m6lkrehi 2193 12 primary primary JJ cord-335975-m6lkrehi 2193 13 pharmacological pharmacological JJ cord-335975-m6lkrehi 2193 14 analysis analysis NN cord-335975-m6lkrehi 2193 15 and and CC cord-335975-m6lkrehi 2193 16 45 45 CD cord-335975-m6lkrehi 2193 17 in in IN cord-335975-m6lkrehi 2193 18 the the DT cord-335975-m6lkrehi 2193 19 secondary secondary JJ cord-335975-m6lkrehi 2193 20 clinical clinical JJ cord-335975-m6lkrehi 2193 21 analysis analysis NN cord-335975-m6lkrehi 2193 22 . . . cord-335975-m6lkrehi 2194 1 Using use VBG cord-335975-m6lkrehi 2194 2 a a DT cord-335975-m6lkrehi 2194 3 MIC MIC NNP cord-335975-m6lkrehi 2194 4 of of IN cord-335975-m6lkrehi 2194 5 16 16 CD cord-335975-m6lkrehi 2194 6 mg mg NNP cord-335975-m6lkrehi 2194 7 L L NNP cord-335975-m6lkrehi 2194 8 −1 −1 NNP cord-335975-m6lkrehi 2194 9 for for IN cord-335975-m6lkrehi 2194 10 piperacillin piperacillin NNP cord-335975-m6lkrehi 2194 11 , , , cord-335975-m6lkrehi 2194 12 the the DT cord-335975-m6lkrehi 2194 13 rate rate NN cord-335975-m6lkrehi 2194 14 of of IN cord-335975-m6lkrehi 2194 15 empirical empirical JJ cord-335975-m6lkrehi 2194 16 target target NN cord-335975-m6lkrehi 2194 17 non non JJ cord-335975-m6lkrehi 2194 18 - - JJ cord-335975-m6lkrehi 2194 19 attainment attainment JJ cord-335975-m6lkrehi 2194 20 in in IN cord-335975-m6lkrehi 2194 21 the the DT cord-335975-m6lkrehi 2194 22 overall overall JJ cord-335975-m6lkrehi 2194 23 population population NN cord-335975-m6lkrehi 2194 24 was be VBD cord-335975-m6lkrehi 2194 25 17 17 CD cord-335975-m6lkrehi 2194 26 % % NN cord-335975-m6lkrehi 2194 27 , , , cord-335975-m6lkrehi 2194 28 with with IN cord-335975-m6lkrehi 2194 29 a a DT cord-335975-m6lkrehi 2194 30 strong strong JJ cord-335975-m6lkrehi 2194 31 association association NN cord-335975-m6lkrehi 2194 32 with with IN cord-335975-m6lkrehi 2194 33 CrCL CrCL NNP cord-335975-m6lkrehi 2194 34 ( ( -LRB- cord-335975-m6lkrehi 2194 35 Fig Fig NNP cord-335975-m6lkrehi 2194 36 . . . cord-335975-m6lkrehi 2195 1 1 1 CD cord-335975-m6lkrehi 2195 2 Introduction introduction NN cord-335975-m6lkrehi 2195 3 : : : cord-335975-m6lkrehi 2196 1 Invasive invasive JJ cord-335975-m6lkrehi 2196 2 fungal fungal JJ cord-335975-m6lkrehi 2196 3 infections infection NNS cord-335975-m6lkrehi 2196 4 are be VBP cord-335975-m6lkrehi 2196 5 a a DT cord-335975-m6lkrehi 2196 6 major major JJ cord-335975-m6lkrehi 2196 7 burden burden NN cord-335975-m6lkrehi 2196 8 in in IN cord-335975-m6lkrehi 2196 9 solid solid JJ cord-335975-m6lkrehi 2196 10 organ organ NN cord-335975-m6lkrehi 2196 11 transplantation transplantation NN cord-335975-m6lkrehi 2196 12 , , , cord-335975-m6lkrehi 2196 13 especially especially RB cord-335975-m6lkrehi 2196 14 in in IN cord-335975-m6lkrehi 2196 15 patients patient NNS cord-335975-m6lkrehi 2196 16 receiving receive VBG cord-335975-m6lkrehi 2196 17 liver liver NN cord-335975-m6lkrehi 2196 18 graft graft NN cord-335975-m6lkrehi 2196 19 . . . cord-335975-m6lkrehi 2197 1 However however RB cord-335975-m6lkrehi 2197 2 , , , cord-335975-m6lkrehi 2197 3 their -PRON- PRP$ cord-335975-m6lkrehi 2197 4 incidence incidence NN cord-335975-m6lkrehi 2197 5 has have VBZ cord-335975-m6lkrehi 2197 6 decreased decrease VBN cord-335975-m6lkrehi 2197 7 thanks thank NNS cord-335975-m6lkrehi 2197 8 to to IN cord-335975-m6lkrehi 2197 9 the the DT cord-335975-m6lkrehi 2197 10 development development NN cord-335975-m6lkrehi 2197 11 of of IN cord-335975-m6lkrehi 2197 12 an an DT cord-335975-m6lkrehi 2197 13 antifungal antifungal JJ cord-335975-m6lkrehi 2197 14 prophylaxis prophylaxis NN cord-335975-m6lkrehi 2197 15 in in IN cord-335975-m6lkrehi 2197 16 the the DT cord-335975-m6lkrehi 2197 17 post post JJ cord-335975-m6lkrehi 2197 18 - - JJ cord-335975-m6lkrehi 2197 19 transplantation transplantation JJ cord-335975-m6lkrehi 2197 20 period period NN cord-335975-m6lkrehi 2197 21 . . . cord-335975-m6lkrehi 2198 1 In in IN cord-335975-m6lkrehi 2198 2 patients patient NNS cord-335975-m6lkrehi 2198 3 at at IN cord-335975-m6lkrehi 2198 4 high high JJ cord-335975-m6lkrehi 2198 5 risk risk NN cord-335975-m6lkrehi 2198 6 of of IN cord-335975-m6lkrehi 2198 7 invasive invasive JJ cord-335975-m6lkrehi 2198 8 fungal fungal JJ cord-335975-m6lkrehi 2198 9 infection infection NN cord-335975-m6lkrehi 2198 10 ( ( -LRB- cord-335975-m6lkrehi 2198 11 IFI IFI NNP cord-335975-m6lkrehi 2198 12 ) ) -RRB- cord-335975-m6lkrehi 2198 13 , , , cord-335975-m6lkrehi 2198 14 this this DT cord-335975-m6lkrehi 2198 15 strategy strategy NN cord-335975-m6lkrehi 2198 16 is be VBZ cord-335975-m6lkrehi 2198 17 recommended recommend VBN cord-335975-m6lkrehi 2198 18 , , , cord-335975-m6lkrehi 2198 19 whereas whereas IN cord-335975-m6lkrehi 2198 20 its -PRON- PRP$ cord-335975-m6lkrehi 2198 21 benefit benefit NN cord-335975-m6lkrehi 2198 22 remains remain VBZ cord-335975-m6lkrehi 2198 23 controversial controversial JJ cord-335975-m6lkrehi 2198 24 in in IN cord-335975-m6lkrehi 2198 25 low low JJ cord-335975-m6lkrehi 2198 26 - - HYPH cord-335975-m6lkrehi 2198 27 risk risk NN cord-335975-m6lkrehi 2198 28 patients patient NNS cord-335975-m6lkrehi 2198 29 . . . cord-335975-m6lkrehi 2199 1 However however RB cord-335975-m6lkrehi 2199 2 , , , cord-335975-m6lkrehi 2199 3 there there EX cord-335975-m6lkrehi 2199 4 is be VBZ cord-335975-m6lkrehi 2199 5 no no DT cord-335975-m6lkrehi 2199 6 clear clear JJ cord-335975-m6lkrehi 2199 7 definition definition NN cord-335975-m6lkrehi 2199 8 of of IN cord-335975-m6lkrehi 2199 9 these these DT cord-335975-m6lkrehi 2199 10 two two CD cord-335975-m6lkrehi 2199 11 patients patient NNS cord-335975-m6lkrehi 2199 12 groups group NNS cord-335975-m6lkrehi 2199 13 . . . cord-335975-m6lkrehi 2200 1 Our -PRON- PRP$ cord-335975-m6lkrehi 2200 2 aim aim NN cord-335975-m6lkrehi 2200 3 was be VBD cord-335975-m6lkrehi 2200 4 to to TO cord-335975-m6lkrehi 2200 5 provide provide VB cord-335975-m6lkrehi 2200 6 recent recent JJ cord-335975-m6lkrehi 2200 7 data datum NNS cord-335975-m6lkrehi 2200 8 on on IN cord-335975-m6lkrehi 2200 9 epidemiology epidemiology NN cord-335975-m6lkrehi 2200 10 , , , cord-335975-m6lkrehi 2200 11 mortality mortality NN cord-335975-m6lkrehi 2200 12 and and CC cord-335975-m6lkrehi 2200 13 IFI IFI NNP cord-335975-m6lkrehi 2200 14 risk risk NN cord-335975-m6lkrehi 2200 15 factors factor NNS cord-335975-m6lkrehi 2200 16 in in IN cord-335975-m6lkrehi 2200 17 the the DT cord-335975-m6lkrehi 2200 18 early early JJ cord-335975-m6lkrehi 2200 19 post post JJ cord-335975-m6lkrehi 2200 20 - - JJ cord-335975-m6lkrehi 2200 21 operative operative JJ cord-335975-m6lkrehi 2200 22 course course NN cord-335975-m6lkrehi 2200 23 in in IN cord-335975-m6lkrehi 2200 24 a a DT cord-335975-m6lkrehi 2200 25 population population NN cord-335975-m6lkrehi 2200 26 without without IN cord-335975-m6lkrehi 2200 27 any any DT cord-335975-m6lkrehi 2200 28 antifungal antifungal JJ cord-335975-m6lkrehi 2200 29 prophylaxis prophylaxis NN cord-335975-m6lkrehi 2200 30 . . . cord-335975-m6lkrehi 2201 1 Results result NNS cord-335975-m6lkrehi 2201 2 : : : cord-335975-m6lkrehi 2202 1 The the DT cord-335975-m6lkrehi 2202 2 number number NN cord-335975-m6lkrehi 2202 3 of of IN cord-335975-m6lkrehi 2202 4 beta beta NN cord-335975-m6lkrehi 2202 5 - - HYPH cord-335975-m6lkrehi 2202 6 lactam lactam NN cord-335975-m6lkrehi 2202 7 antibiotics antibiotic NNS cord-335975-m6lkrehi 2202 8 was be VBD cord-335975-m6lkrehi 2202 9 119 119 CD cord-335975-m6lkrehi 2202 10 . . . cord-335975-m6lkrehi 2203 1 Of of IN cord-335975-m6lkrehi 2203 2 these these DT cord-335975-m6lkrehi 2203 3 119 119 CD cord-335975-m6lkrehi 2203 4 requests request NNS cord-335975-m6lkrehi 2203 5 , , , cord-335975-m6lkrehi 2203 6 half half NN cord-335975-m6lkrehi 2203 7 were be VBD cord-335975-m6lkrehi 2203 8 for for IN cord-335975-m6lkrehi 2203 9 piperacillin piperacillin NNP cord-335975-m6lkrehi 2203 10 ( ( -LRB- cord-335975-m6lkrehi 2203 11 49.6 49.6 CD cord-335975-m6lkrehi 2203 12 % % NN cord-335975-m6lkrehi 2203 13 ) ) -RRB- cord-335975-m6lkrehi 2203 14 , , , cord-335975-m6lkrehi 2203 15 and and CC cord-335975-m6lkrehi 2203 16 onethird onethird NN cord-335975-m6lkrehi 2203 17 were be VBD cord-335975-m6lkrehi 2203 18 for for IN cord-335975-m6lkrehi 2203 19 amoxicillin amoxicillin NNP cord-335975-m6lkrehi 2203 20 ( ( -LRB- cord-335975-m6lkrehi 2203 21 30.3 30.3 CD cord-335975-m6lkrehi 2203 22 % % NN cord-335975-m6lkrehi 2203 23 ) ) -RRB- cord-335975-m6lkrehi 2203 24 . . . cord-335975-m6lkrehi 2204 1 The the DT cord-335975-m6lkrehi 2204 2 other other JJ cord-335975-m6lkrehi 2204 3 dosages dosage NNS cord-335975-m6lkrehi 2204 4 were be VBD cord-335975-m6lkrehi 2204 5 mainly mainly RB cord-335975-m6lkrehi 2204 6 for for IN cord-335975-m6lkrehi 2204 7 cloxacillin cloxacillin NNP cord-335975-m6lkrehi 2204 8 , , , cord-335975-m6lkrehi 2204 9 cefepime cefepime NNP cord-335975-m6lkrehi 2204 10 , , , cord-335975-m6lkrehi 2204 11 cefotaxime cefotaxime NN cord-335975-m6lkrehi 2204 12 and and CC cord-335975-m6lkrehi 2204 13 ceftriaxone ceftriaxone NN cord-335975-m6lkrehi 2204 14 . . . cord-335975-m6lkrehi 2205 1 The the DT cord-335975-m6lkrehi 2205 2 results result NNS cord-335975-m6lkrehi 2205 3 confirmed confirm VBD cord-335975-m6lkrehi 2205 4 that that IN cord-335975-m6lkrehi 2205 5 serum serum NN cord-335975-m6lkrehi 2205 6 concentrations concentration NNS cord-335975-m6lkrehi 2205 7 of of IN cord-335975-m6lkrehi 2205 8 piperacillin piperacillin NNP cord-335975-m6lkrehi 2205 9 ( ( -LRB- cord-335975-m6lkrehi 2205 10 21.6 21.6 CD cord-335975-m6lkrehi 2205 11 ± ± NNP cord-335975-m6lkrehi 2205 12 4.0 4.0 CD cord-335975-m6lkrehi 2205 13 vs vs IN cord-335975-m6lkrehi 2205 14 98.2 98.2 CD cord-335975-m6lkrehi 2205 15 ± ± CD cord-335975-m6lkrehi 2205 16 16.8 16.8 CD cord-335975-m6lkrehi 2205 17 mg mg NNP cord-335975-m6lkrehi 2205 18 L L NNP cord-335975-m6lkrehi 2205 19 −1 −1 NNP cord-335975-m6lkrehi 2205 20 < < XX cord-335975-m6lkrehi 2205 21 0.0001 0.0001 CD cord-335975-m6lkrehi 2205 22 ) ) -RRB- cord-335975-m6lkrehi 2205 23 and and CC cord-335975-m6lkrehi 2205 24 amoxicillin amoxicillin NNP cord-335975-m6lkrehi 2205 25 ( ( -LRB- cord-335975-m6lkrehi 2205 26 35.8 35.8 CD cord-335975-m6lkrehi 2205 27 ± ± CD cord-335975-m6lkrehi 2205 28 13.0 13.0 CD cord-335975-m6lkrehi 2205 29 vs vs IN cord-335975-m6lkrehi 2205 30 157 157 CD cord-335975-m6lkrehi 2205 31 ± ± CD cord-335975-m6lkrehi 2205 32 72 72 CD cord-335975-m6lkrehi 2206 1 mg mg NNP cord-335975-m6lkrehi 2206 2 L L NNP cord-335975-m6lkrehi 2206 3 −1 −1 NNP cord-335975-m6lkrehi 2207 1 < < NNP cord-335975-m6lkrehi 2207 2 0.0001 0.0001 CD cord-335975-m6lkrehi 2207 3 ) ) -RRB- cord-335975-m6lkrehi 2207 4 significantly significantly RB cord-335975-m6lkrehi 2207 5 were be VBD cord-335975-m6lkrehi 2207 6 higher high JJR cord-335975-m6lkrehi 2207 7 in in IN cord-335975-m6lkrehi 2207 8 patients patient NNS cord-335975-m6lkrehi 2207 9 with with IN cord-335975-m6lkrehi 2207 10 neurological neurological JJ cord-335975-m6lkrehi 2207 11 disorders disorder NNS cord-335975-m6lkrehi 2207 12 or or CC cord-335975-m6lkrehi 2207 13 wakefulness wakefulness NN cord-335975-m6lkrehi 2207 14 delays delay NNS cord-335975-m6lkrehi 2207 15 . . . cord-335975-m6lkrehi 2208 1 The the DT cord-335975-m6lkrehi 2208 2 ROC ROC NNP cord-335975-m6lkrehi 2208 3 curves curve NNS cord-335975-m6lkrehi 2208 4 allowed allow VBD cord-335975-m6lkrehi 2208 5 the the DT cord-335975-m6lkrehi 2208 6 predictive predictive JJ cord-335975-m6lkrehi 2208 7 values value NNS cord-335975-m6lkrehi 2208 8 associated associate VBN cord-335975-m6lkrehi 2208 9 with with IN cord-335975-m6lkrehi 2208 10 the the DT cord-335975-m6lkrehi 2208 11 presence presence NN cord-335975-m6lkrehi 2208 12 of of IN cord-335975-m6lkrehi 2208 13 neurological neurological JJ cord-335975-m6lkrehi 2208 14 disorders disorder NNS cord-335975-m6lkrehi 2208 15 attributable attributable JJ cord-335975-m6lkrehi 2208 16 to to IN cord-335975-m6lkrehi 2208 17 antibiotic antibiotic JJ cord-335975-m6lkrehi 2208 18 treatment treatment NN cord-335975-m6lkrehi 2208 19 , , , cord-335975-m6lkrehi 2208 20 corresponding correspond VBG cord-335975-m6lkrehi 2208 21 to to IN cord-335975-m6lkrehi 2208 22 residual residual JJ cord-335975-m6lkrehi 2208 23 serum serum NN cord-335975-m6lkrehi 2208 24 concentrations concentration NNS cord-335975-m6lkrehi 2208 25 of of IN cord-335975-m6lkrehi 2208 26 piperacillin piperacillin NN cord-335975-m6lkrehi 2208 27 of of IN cord-335975-m6lkrehi 2208 28 66 66 CD cord-335975-m6lkrehi 2208 29 mg mg NNP cord-335975-m6lkrehi 2208 30 L L NNP cord-335975-m6lkrehi 2208 31 −1 −1 NNP cord-335975-m6lkrehi 2208 32 and and CC cord-335975-m6lkrehi 2208 33 amoxicillin amoxicillin NNP cord-335975-m6lkrehi 2208 34 of of IN cord-335975-m6lkrehi 2208 35 160 160 CD cord-335975-m6lkrehi 2208 36 mg mg NNP cord-335975-m6lkrehi 2208 37 L L NNP cord-335975-m6lkrehi 2208 38 −1 −1 NNP cord-335975-m6lkrehi 2208 39 . . . cord-335975-m6lkrehi 2209 1 A a DT cord-335975-m6lkrehi 2209 2 predictive predictive JJ cord-335975-m6lkrehi 2209 3 value value NN cord-335975-m6lkrehi 2209 4 for for IN cord-335975-m6lkrehi 2209 5 neurological neurological JJ cord-335975-m6lkrehi 2209 6 disorders disorder NNS cord-335975-m6lkrehi 2209 7 of of IN cord-335975-m6lkrehi 2209 8 these these DT cord-335975-m6lkrehi 2209 9 concentrations concentration NNS cord-335975-m6lkrehi 2209 10 is be VBZ cord-335975-m6lkrehi 2209 11 proposed propose VBN cord-335975-m6lkrehi 2209 12 for for IN cord-335975-m6lkrehi 2209 13 residual residual JJ cord-335975-m6lkrehi 2209 14 serum serum NN cord-335975-m6lkrehi 2209 15 concentrations concentration NNS cord-335975-m6lkrehi 2209 16 greater great JJR cord-335975-m6lkrehi 2209 17 than than IN cord-335975-m6lkrehi 2209 18 40 40 CD cord-335975-m6lkrehi 2209 19 mg mg NNP cord-335975-m6lkrehi 2209 20 L L NNP cord-335975-m6lkrehi 2209 21 −1 −1 NNP cord-335975-m6lkrehi 2209 22 for for IN cord-335975-m6lkrehi 2209 23 both both DT cord-335975-m6lkrehi 2209 24 antibiotics antibiotic NNS cord-335975-m6lkrehi 2209 25 ( ( -LRB- cord-335975-m6lkrehi 2209 26 80 80 CD cord-335975-m6lkrehi 2209 27 % % NN cord-335975-m6lkrehi 2209 28 specificity specificity NN cord-335975-m6lkrehi 2209 29 and and CC cord-335975-m6lkrehi 2209 30 sensitivity sensitivity NN cord-335975-m6lkrehi 2209 31 ) ) -RRB- cord-335975-m6lkrehi 2209 32 . . . cord-335975-m6lkrehi 2210 1 Conclusion conclusion NN cord-335975-m6lkrehi 2210 2 : : : cord-335975-m6lkrehi 2211 1 Our -PRON- PRP$ cord-335975-m6lkrehi 2211 2 results result NNS cord-335975-m6lkrehi 2211 3 suggest suggest VBP cord-335975-m6lkrehi 2211 4 that that IN cord-335975-m6lkrehi 2211 5 there there EX cord-335975-m6lkrehi 2211 6 is be VBZ cord-335975-m6lkrehi 2211 7 an an DT cord-335975-m6lkrehi 2211 8 association association NN cord-335975-m6lkrehi 2211 9 between between IN cord-335975-m6lkrehi 2211 10 a a DT cord-335975-m6lkrehi 2211 11 residual residual JJ cord-335975-m6lkrehi 2211 12 concentration concentration NN cord-335975-m6lkrehi 2211 13 of of IN cord-335975-m6lkrehi 2211 14 piperacillin piperacillin NNP cord-335975-m6lkrehi 2211 15 and and CC cord-335975-m6lkrehi 2211 16 amoxicillin amoxicillin NNP cord-335975-m6lkrehi 2211 17 greater great JJR cord-335975-m6lkrehi 2211 18 than than IN cord-335975-m6lkrehi 2211 19 40 40 CD cord-335975-m6lkrehi 2211 20 mg mg NNP cord-335975-m6lkrehi 2211 21 L L NNP cord-335975-m6lkrehi 2211 22 −1 −1 NNP cord-335975-m6lkrehi 2211 23 and and CC cord-335975-m6lkrehi 2211 24 the the DT cord-335975-m6lkrehi 2211 25 occurrence occurrence NN cord-335975-m6lkrehi 2211 26 of of IN cord-335975-m6lkrehi 2211 27 neurological neurological JJ cord-335975-m6lkrehi 2211 28 disorders disorder NNS cord-335975-m6lkrehi 2211 29 . . . cord-335975-m6lkrehi 2212 1 Pharmacological pharmacological JJ cord-335975-m6lkrehi 2212 2 therapeutic therapeutic JJ cord-335975-m6lkrehi 2212 3 monitoring monitoring NN cord-335975-m6lkrehi 2212 4 of of IN cord-335975-m6lkrehi 2212 5 beta beta NN cord-335975-m6lkrehi 2212 6 - - HYPH cord-335975-m6lkrehi 2212 7 lactams lactam NNS cord-335975-m6lkrehi 2212 8 in in IN cord-335975-m6lkrehi 2212 9 critically critically RB cord-335975-m6lkrehi 2212 10 ill ill JJ cord-335975-m6lkrehi 2212 11 patients patient NNS cord-335975-m6lkrehi 2212 12 may may MD cord-335975-m6lkrehi 2212 13 be be VB cord-335975-m6lkrehi 2212 14 a a DT cord-335975-m6lkrehi 2212 15 useful useful JJ cord-335975-m6lkrehi 2212 16 intervention intervention NN cord-335975-m6lkrehi 2212 17 to to TO cord-335975-m6lkrehi 2212 18 optimize optimize VB cord-335975-m6lkrehi 2212 19 the the DT cord-335975-m6lkrehi 2212 20 antibiotic antibiotic JJ cord-335975-m6lkrehi 2212 21 regimens regimen NNS cord-335975-m6lkrehi 2212 22 and and CC cord-335975-m6lkrehi 2212 23 to to TO cord-335975-m6lkrehi 2212 24 avoid avoid VB cord-335975-m6lkrehi 2212 25 antibiotic antibiotic NN cord-335975-m6lkrehi 2212 26 - - HYPH cord-335975-m6lkrehi 2212 27 related relate VBN cord-335975-m6lkrehi 2212 28 toxicities toxicity NNS cord-335975-m6lkrehi 2212 29 . . . cord-335975-m6lkrehi 2213 1 ( ( -LRB- cord-335975-m6lkrehi 2213 2 2011 2011 CD cord-335975-m6lkrehi 2213 3 ) ) -RRB- cord-335975-m6lkrehi 2214 1 ( ( -LRB- cord-335975-m6lkrehi 2214 2 2012 2012 CD cord-335975-m6lkrehi 2214 3 ) ) -RRB- cord-335975-m6lkrehi 2215 1 ( ( -LRB- cord-335975-m6lkrehi 2215 2 2013 2013 CD cord-335975-m6lkrehi 2215 3 ) ) -RRB- cord-335975-m6lkrehi 2216 1 ( ( -LRB- cord-335975-m6lkrehi 2216 2 2014 2014 CD cord-335975-m6lkrehi 2216 3 ) ) -RRB- cord-335975-m6lkrehi 2216 4 ( ( -LRB- cord-335975-m6lkrehi 2216 5 2015 2015 CD cord-335975-m6lkrehi 2216 6 ) ) -RRB- cord-335975-m6lkrehi 2216 7 . . . cord-335975-m6lkrehi 2217 1 Patients patient NNS cord-335975-m6lkrehi 2217 2 with with IN cord-335975-m6lkrehi 2217 3 a a DT cord-335975-m6lkrehi 2217 4 GNB GNB NNP cord-335975-m6lkrehi 2217 5 - - HYPH cord-335975-m6lkrehi 2217 6 BSI BSI NNP cord-335975-m6lkrehi 2217 7 were be VBD cord-335975-m6lkrehi 2217 8 included include VBN cord-335975-m6lkrehi 2217 9 and and CC cord-335975-m6lkrehi 2217 10 were be VBD cord-335975-m6lkrehi 2217 11 divided divide VBN cord-335975-m6lkrehi 2217 12 into into IN cord-335975-m6lkrehi 2217 13 two two CD cord-335975-m6lkrehi 2217 14 groups group NNS cord-335975-m6lkrehi 2217 15 according accord VBG cord-335975-m6lkrehi 2217 16 to to IN cord-335975-m6lkrehi 2217 17 the the DT cord-335975-m6lkrehi 2217 18 resistance resistance NN cord-335975-m6lkrehi 2217 19 ( ( -LRB- cord-335975-m6lkrehi 2217 20 R r NN cord-335975-m6lkrehi 2217 21 ) ) -RRB- cord-335975-m6lkrehi 2217 22 profile profile NN cord-335975-m6lkrehi 2217 23 ( ( -LRB- cord-335975-m6lkrehi 2217 24 BSI BSI NNP cord-335975-m6lkrehi 2217 25 due due IN cord-335975-m6lkrehi 2217 26 to to IN cord-335975-m6lkrehi 2217 27 a a DT cord-335975-m6lkrehi 2217 28 R r NN cord-335975-m6lkrehi 2217 29 isolate isolate NN cord-335975-m6lkrehi 2217 30 or or CC cord-335975-m6lkrehi 2217 31 not not RB cord-335975-m6lkrehi 2217 32 ) ) -RRB- cord-335975-m6lkrehi 2217 33 . . . cord-335975-m6lkrehi 2218 1 The the DT cord-335975-m6lkrehi 2218 2 following following JJ cord-335975-m6lkrehi 2218 3 resistances resistance NNS cord-335975-m6lkrehi 2218 4 were be VBD cord-335975-m6lkrehi 2218 5 considered consider VBN cord-335975-m6lkrehi 2218 6 - - : cord-335975-m6lkrehi 2218 7 all all DT cord-335975-m6lkrehi 2218 8 GNB GNB NNP cord-335975-m6lkrehi 2218 9 - - HYPH cord-335975-m6lkrehi 2218 10 BSI BSI NNP cord-335975-m6lkrehi 2218 11 including include VBG cord-335975-m6lkrehi 2218 12 Pseudomonas Pseudomonas NNP cord-335975-m6lkrehi 2218 13 spp spp NNS cord-335975-m6lkrehi 2218 14 . . . cord-335975-m6lkrehi 2219 1 , , , cord-335975-m6lkrehi 2219 2 Acinetobacter Acinetobacter NNP cord-335975-m6lkrehi 2219 3 spp spp NNS cord-335975-m6lkrehi 2219 4 . . . cord-335975-m6lkrehi 2220 1 , , , cord-335975-m6lkrehi 2220 2 Stenotrophomonas Stenotrophomonas NNP cord-335975-m6lkrehi 2220 3 spp spp NNS cord-335975-m6lkrehi 2220 4 . . . cord-335975-m6lkrehi 2221 1 and and CC cord-335975-m6lkrehi 2221 2 Enterobacteriacae Enterobacteriacae NNP cord-335975-m6lkrehi 2221 3 ( ( -LRB- cord-335975-m6lkrehi 2221 4 Eb Eb NNP cord-335975-m6lkrehi 2221 5 ) ) -RRB- cord-335975-m6lkrehi 2221 6 for for IN cord-335975-m6lkrehi 2221 7 which which WDT cord-335975-m6lkrehi 2221 8 the the DT cord-335975-m6lkrehi 2221 9 following following JJ cord-335975-m6lkrehi 2221 10 antimicrobial antimicrobial JJ cord-335975-m6lkrehi 2221 11 resistances resistance NNS cord-335975-m6lkrehi 2221 12 were be VBD cord-335975-m6lkrehi 2221 13 considered consider VBN cord-335975-m6lkrehi 2221 14 - - HYPH cord-335975-m6lkrehi 2221 15 ticarcillin ticarcillin NN cord-335975-m6lkrehi 2221 16 and and CC cord-335975-m6lkrehi 2221 17 ceftazidime ceftazidime NNP cord-335975-m6lkrehi 2221 18 ( ( -LRB- cord-335975-m6lkrehi 2221 19 cefta cefta NNP cord-335975-m6lkrehi 2221 20 ) ) -RRB- cord-335975-m6lkrehi 2221 21 ( ( -LRB- cord-335975-m6lkrehi 2221 22 Pseudomonas Pseudomonas NNP cord-335975-m6lkrehi 2221 23 ( ( -LRB- cord-335975-m6lkrehi 2221 24 PA PA NNP cord-335975-m6lkrehi 2221 25 ) ) -RRB- cord-335975-m6lkrehi 2221 26 ) ) -RRB- cord-335975-m6lkrehi 2221 27 , , , cord-335975-m6lkrehi 2221 28 third third JJ cord-335975-m6lkrehi 2221 29 generation generation NN cord-335975-m6lkrehi 2221 30 cephalosporin cephalosporin NN cord-335975-m6lkrehi 2221 31 ( ( -LRB- cord-335975-m6lkrehi 2221 32 3GC 3gc CD cord-335975-m6lkrehi 2221 33 ) ) -RRB- cord-335975-m6lkrehi 2221 34 ( ( -LRB- cord-335975-m6lkrehi 2221 35 Eb Eb NNP cord-335975-m6lkrehi 2221 36 ) ) -RRB- cord-335975-m6lkrehi 2221 37 and and CC cord-335975-m6lkrehi 2221 38 imipenem imipenem NNP cord-335975-m6lkrehi 2221 39 ( ( -LRB- cord-335975-m6lkrehi 2221 40 all all DT cord-335975-m6lkrehi 2221 41 GNB GNB NNP cord-335975-m6lkrehi 2221 42 ) ) -RRB- cord-335975-m6lkrehi 2221 43 . . . cord-335975-m6lkrehi 2222 1 After after IN cord-335975-m6lkrehi 2222 2 variable variable JJ cord-335975-m6lkrehi 2222 3 selection selection NN cord-335975-m6lkrehi 2222 4 using use VBG cord-335975-m6lkrehi 2222 5 random random JJ cord-335975-m6lkrehi 2222 6 forest forest NN cord-335975-m6lkrehi 2222 7 and and CC cord-335975-m6lkrehi 2222 8 univariable univariable JJ cord-335975-m6lkrehi 2222 9 mixed mixed JJ cord-335975-m6lkrehi 2222 10 logistic logistic JJ cord-335975-m6lkrehi 2222 11 regression regression NN cord-335975-m6lkrehi 2222 12 models model NNS cord-335975-m6lkrehi 2222 13 , , , cord-335975-m6lkrehi 2222 14 a a DT cord-335975-m6lkrehi 2222 15 multivariable multivariable JJ cord-335975-m6lkrehi 2222 16 analyses analysis NNS cord-335975-m6lkrehi 2222 17 using use VBG cord-335975-m6lkrehi 2222 18 a a DT cord-335975-m6lkrehi 2222 19 mixed mixed JJ cord-335975-m6lkrehi 2222 20 model model NN cord-335975-m6lkrehi 2222 21 with with IN cord-335975-m6lkrehi 2222 22 a a DT cord-335975-m6lkrehi 2222 23 random random JJ cord-335975-m6lkrehi 2222 24 effect effect NN cord-335975-m6lkrehi 2222 25 ( ( -LRB- cord-335975-m6lkrehi 2222 26 center center NN cord-335975-m6lkrehi 2222 27 ) ) -RRB- cord-335975-m6lkrehi 2222 28 . . . cord-335975-m6lkrehi 2223 1 Sub sub JJ cord-335975-m6lkrehi 2223 2 - - HYPH cord-335975-m6lkrehi 2223 3 group group NN cord-335975-m6lkrehi 2223 4 analyses analysis NNS cord-335975-m6lkrehi 2223 5 were be VBD cord-335975-m6lkrehi 2223 6 performed perform VBN cord-335975-m6lkrehi 2223 7 according accord VBG cord-335975-m6lkrehi 2223 8 to to IN cord-335975-m6lkrehi 2223 9 species specie NNS cord-335975-m6lkrehi 2223 10 ( ( -LRB- cord-335975-m6lkrehi 2223 11 PA PA NNP cord-335975-m6lkrehi 2223 12 and and CC cord-335975-m6lkrehi 2223 13 Eb Eb NNP cord-335975-m6lkrehi 2223 14 ) ) -RRB- cord-335975-m6lkrehi 2223 15 and and CC cord-335975-m6lkrehi 2223 16 resistance resistance NN cord-335975-m6lkrehi 2223 17 for for IN cord-335975-m6lkrehi 2223 18 Eb Eb NNP cord-335975-m6lkrehi 2223 19 . . . cord-335975-m6lkrehi 2224 1 Results result NNS cord-335975-m6lkrehi 2224 2 : : : cord-335975-m6lkrehi 2225 1 From from IN cord-335975-m6lkrehi 2225 2 189,020 189,020 CD cord-335975-m6lkrehi 2225 3 patients patient NNS cord-335975-m6lkrehi 2225 4 admitted admit VBN cord-335975-m6lkrehi 2225 5 in in IN cord-335975-m6lkrehi 2225 6 an an DT cord-335975-m6lkrehi 2225 7 annual annual JJ cord-335975-m6lkrehi 2225 8 median median NN cord-335975-m6lkrehi 2225 9 of of IN cord-335975-m6lkrehi 2225 10 198 198 CD cord-335975-m6lkrehi 2225 11 French french JJ cord-335975-m6lkrehi 2225 12 ICUs icu NNS cord-335975-m6lkrehi 2225 13 , , , cord-335975-m6lkrehi 2225 14 6837 6837 CD cord-335975-m6lkrehi 2225 15 experienced experience VBD cord-335975-m6lkrehi 2225 16 an an DT cord-335975-m6lkrehi 2225 17 ICU ICU NNP cord-335975-m6lkrehi 2225 18 - - HYPH cord-335975-m6lkrehi 2225 19 acquired acquire VBN cord-335975-m6lkrehi 2225 20 ( ( -LRB- cord-335975-m6lkrehi 2225 21 > > NFP cord-335975-m6lkrehi 2225 22 48 48 CD cord-335975-m6lkrehi 2225 23 h. h. NN cord-335975-m6lkrehi 2225 24 ) ) -RRB- cord-335975-m6lkrehi 2225 25 BSI BSI NNP cord-335975-m6lkrehi 2225 26 , , , cord-335975-m6lkrehi 2225 27 3462 3462 CD cord-335975-m6lkrehi 2225 28 ( ( -LRB- cord-335975-m6lkrehi 2225 29 51 51 CD cord-335975-m6lkrehi 2225 30 % % NN cord-335975-m6lkrehi 2225 31 ) ) -RRB- cord-335975-m6lkrehi 2225 32 BSI BSI NNP cord-335975-m6lkrehi 2225 33 due due IN cord-335975-m6lkrehi 2225 34 to to IN cord-335975-m6lkrehi 2225 35 GNB GNB NNP cord-335975-m6lkrehi 2225 36 , , , cord-335975-m6lkrehi 2225 37 including include VBG cord-335975-m6lkrehi 2225 38 1345 1345 CD cord-335975-m6lkrehi 2225 39 ( ( -LRB- cord-335975-m6lkrehi 2225 40 41 41 CD cord-335975-m6lkrehi 2225 41 % % NN cord-335975-m6lkrehi 2225 42 ) ) -RRB- cord-335975-m6lkrehi 2226 1 BSI BSI NNP cord-335975-m6lkrehi 2226 2 due due JJ cord-335975-m6lkrehi 2226 3 to to IN cord-335975-m6lkrehi 2226 4 R r NN cord-335975-m6lkrehi 2226 5 isolates isolate NNS cord-335975-m6lkrehi 2226 6 . . . cord-335975-m6lkrehi 2227 1 PA PA NNP cord-335975-m6lkrehi 2227 2 was be VBD cord-335975-m6lkrehi 2227 3 identified identify VBN cord-335975-m6lkrehi 2227 4 in in IN cord-335975-m6lkrehi 2227 5 828 828 CD cord-335975-m6lkrehi 2227 6 ( ( -LRB- cord-335975-m6lkrehi 2227 7 24 24 CD cord-335975-m6lkrehi 2227 8 % % NN cord-335975-m6lkrehi 2227 9 ) ) -RRB- cord-335975-m6lkrehi 2228 1 ( ( -LRB- cord-335975-m6lkrehi 2228 2 MDR MDR NNP cord-335975-m6lkrehi 2228 3 - - HYPH cord-335975-m6lkrehi 2228 4 PA PA NNP cord-335975-m6lkrehi 2228 5 BSIs BSIs NNP cord-335975-m6lkrehi 2228 6 248 248 CD cord-335975-m6lkrehi 2228 7 ( ( -LRB- cord-335975-m6lkrehi 2228 8 30 30 CD cord-335975-m6lkrehi 2228 9 % % NN cord-335975-m6lkrehi 2228 10 ) ) -RRB- cord-335975-m6lkrehi 2228 11 ) ) -RRB- cord-335975-m6lkrehi 2228 12 and and CC cord-335975-m6lkrehi 2228 13 Eb Eb NNP cord-335975-m6lkrehi 2228 14 in in IN cord-335975-m6lkrehi 2228 15 2933 2933 CD cord-335975-m6lkrehi 2228 16 ( ( -LRB- cord-335975-m6lkrehi 2228 17 86 86 CD cord-335975-m6lkrehi 2228 18 % % NN cord-335975-m6lkrehi 2228 19 ) ) -RRB- cord-335975-m6lkrehi 2229 1 ( ( -LRB- cord-335975-m6lkrehi 2229 2 MDR MDR NNP cord-335975-m6lkrehi 2229 3 - - HYPH cord-335975-m6lkrehi 2229 4 Eb Eb NNP cord-335975-m6lkrehi 2229 5 BSIs bsi NNS cord-335975-m6lkrehi 2229 6 ( ( -LRB- cord-335975-m6lkrehi 2229 7 1126 1126 CD cord-335975-m6lkrehi 2229 8 ( ( -LRB- cord-335975-m6lkrehi 2229 9 38 38 CD cord-335975-m6lkrehi 2229 10 % % NN cord-335975-m6lkrehi 2229 11 ) ) -RRB- cord-335975-m6lkrehi 2229 12 ) ) -RRB- cord-335975-m6lkrehi 2229 13 . . . cord-335975-m6lkrehi 2230 1 The the DT cord-335975-m6lkrehi 2230 2 raw raw JJ cord-335975-m6lkrehi 2230 3 mortality mortality NN cord-335975-m6lkrehi 2230 4 rate rate NN cord-335975-m6lkrehi 2230 5 was be VBD cord-335975-m6lkrehi 2230 6 18 18 CD cord-335975-m6lkrehi 2230 7 % % NN cord-335975-m6lkrehi 2230 8 in in IN cord-335975-m6lkrehi 2230 9 the the DT cord-335975-m6lkrehi 2230 10 overall overall JJ cord-335975-m6lkrehi 2230 11 population population NN cord-335975-m6lkrehi 2230 12 and and CC cord-335975-m6lkrehi 2230 13 38 38 CD cord-335975-m6lkrehi 2230 14 % % NN cord-335975-m6lkrehi 2230 15 in in IN cord-335975-m6lkrehi 2230 16 the the DT cord-335975-m6lkrehi 2230 17 patient patient NN cord-335975-m6lkrehi 2230 18 with with IN cord-335975-m6lkrehi 2230 19 GNB GNB NNP cord-335975-m6lkrehi 2230 20 BSI BSI NNP cord-335975-m6lkrehi 2230 21 . . . cord-335975-m6lkrehi 2231 1 It -PRON- PRP cord-335975-m6lkrehi 2231 2 was be VBD cord-335975-m6lkrehi 2231 3 significantly significantly RB cord-335975-m6lkrehi 2231 4 higher high JJR cord-335975-m6lkrehi 2231 5 for for IN cord-335975-m6lkrehi 2231 6 R R NNP cord-335975-m6lkrehi 2231 7 GNB GNB NNP cord-335975-m6lkrehi 2231 8 BSI BSI NNP cord-335975-m6lkrehi 2231 9 ( ( -LRB- cord-335975-m6lkrehi 2231 10 41 41 CD cord-335975-m6lkrehi 2231 11 vs vs IN cord-335975-m6lkrehi 2231 12 36 36 CD cord-335975-m6lkrehi 2231 13 % % NN cord-335975-m6lkrehi 2231 14 for for IN cord-335975-m6lkrehi 2231 15 susceptible susceptible JJ cord-335975-m6lkrehi 2231 16 GNB GNB NNP cord-335975-m6lkrehi 2231 17 BSI BSI NNP cord-335975-m6lkrehi 2231 18 , , , cord-335975-m6lkrehi 2231 19 p p NN cord-335975-m6lkrehi 2231 20 < < XX cord-335975-m6lkrehi 2231 21 0.01 0.01 CD cord-335975-m6lkrehi 2231 22 ) ) -RRB- cord-335975-m6lkrehi 2231 23 . . . cord-335975-m6lkrehi 2232 1 After after IN cord-335975-m6lkrehi 2232 2 adequate adequate JJ cord-335975-m6lkrehi 2232 3 adjustment adjustment NN cord-335975-m6lkrehi 2232 4 in in IN cord-335975-m6lkrehi 2232 5 a a DT cord-335975-m6lkrehi 2232 6 multivariate multivariate JJ cord-335975-m6lkrehi 2232 7 analysis analysis NN cord-335975-m6lkrehi 2232 8 , , , cord-335975-m6lkrehi 2232 9 we -PRON- PRP cord-335975-m6lkrehi 2232 10 showed show VBD cord-335975-m6lkrehi 2232 11 that that IN cord-335975-m6lkrehi 2232 12 R R NNP cord-335975-m6lkrehi 2232 13 - - HYPH cord-335975-m6lkrehi 2232 14 GNB GNB NNP cord-335975-m6lkrehi 2232 15 BSI BSI NNP cord-335975-m6lkrehi 2232 16 was be VBD cord-335975-m6lkrehi 2232 17 significantly significantly RB cord-335975-m6lkrehi 2232 18 associated associate VBN cord-335975-m6lkrehi 2232 19 with with IN cord-335975-m6lkrehi 2232 20 mortality mortality NN cord-335975-m6lkrehi 2232 21 compared compare VBN cord-335975-m6lkrehi 2232 22 to to IN cord-335975-m6lkrehi 2232 23 susceptible susceptible JJ cord-335975-m6lkrehi 2232 24 strains strain NNS cord-335975-m6lkrehi 2232 25 ( ( -LRB- cord-335975-m6lkrehi 2232 26 Fig fig NN cord-335975-m6lkrehi 2232 27 . . . cord-335975-m6lkrehi 2232 28 1 1 CD cord-335975-m6lkrehi 2232 29 ) ) -RRB- cord-335975-m6lkrehi 2232 30 . . . cord-335975-m6lkrehi 2233 1 By by IN cord-335975-m6lkrehi 2233 2 considering consider VBG cord-335975-m6lkrehi 2233 3 species specie NNS cord-335975-m6lkrehi 2233 4 subgroup subgroup NN cord-335975-m6lkrehi 2233 5 , , , cord-335975-m6lkrehi 2233 6 the the DT cord-335975-m6lkrehi 2233 7 effect effect NN cord-335975-m6lkrehi 2233 8 was be VBD cord-335975-m6lkrehi 2233 9 not not RB cord-335975-m6lkrehi 2233 10 significant significant JJ cord-335975-m6lkrehi 2233 11 for for IN cord-335975-m6lkrehi 2233 12 resistant resistant JJ cord-335975-m6lkrehi 2233 13 Pseudomonas Pseudomonas NNP cord-335975-m6lkrehi 2233 14 aeruginosa aeruginosa NN cord-335975-m6lkrehi 2233 15 ( ( -LRB- cord-335975-m6lkrehi 2233 16 p p NN cord-335975-m6lkrehi 2233 17 = = SYM cord-335975-m6lkrehi 2233 18 0.54 0.54 CD cord-335975-m6lkrehi 2233 19 ) ) -RRB- cord-335975-m6lkrehi 2233 20 but but CC cord-335975-m6lkrehi 2233 21 remained remain VBD cord-335975-m6lkrehi 2233 22 significant significant JJ cord-335975-m6lkrehi 2233 23 when when WRB cord-335975-m6lkrehi 2233 24 considering consider VBG cord-335975-m6lkrehi 2233 25 only only RB cord-335975-m6lkrehi 2233 26 Eb Eb NNP cord-335975-m6lkrehi 2233 27 . . . cord-335975-m6lkrehi 2234 1 Considering consider VBG cord-335975-m6lkrehi 2234 2 Eb Eb NNP cord-335975-m6lkrehi 2234 3 resistance resistance NN cord-335975-m6lkrehi 2234 4 , , , cord-335975-m6lkrehi 2234 5 the the DT cord-335975-m6lkrehi 2234 6 impact impact NN cord-335975-m6lkrehi 2234 7 of of IN cord-335975-m6lkrehi 2234 8 3GC 3GC NNP cord-335975-m6lkrehi 2234 9 R r NN cord-335975-m6lkrehi 2234 10 showed show VBD cord-335975-m6lkrehi 2234 11 a a DT cord-335975-m6lkrehi 2234 12 trend trend NN cord-335975-m6lkrehi 2234 13 to to IN cord-335975-m6lkrehi 2234 14 an an DT cord-335975-m6lkrehi 2234 15 increased increase VBN cord-335975-m6lkrehi 2234 16 mortality mortality NN cord-335975-m6lkrehi 2234 17 risk risk NN cord-335975-m6lkrehi 2234 18 whatever whatever WDT cord-335975-m6lkrehi 2234 19 there there EX cord-335975-m6lkrehi 2234 20 was be VBD cord-335975-m6lkrehi 2234 21 no no DT cord-335975-m6lkrehi 2234 22 effect effect NN cord-335975-m6lkrehi 2234 23 of of IN cord-335975-m6lkrehi 2234 24 IMI IMI NNP cord-335975-m6lkrehi 2234 25 R R NNP cord-335975-m6lkrehi 2234 26 ( ( -LRB- cord-335975-m6lkrehi 2234 27 N n NN cord-335975-m6lkrehi 2234 28 = = SYM cord-335975-m6lkrehi 2234 29 45 45 CD cord-335975-m6lkrehi 2234 30 ( ( -LRB- cord-335975-m6lkrehi 2234 31 2 2 CD cord-335975-m6lkrehi 2234 32 % % NN cord-335975-m6lkrehi 2234 33 ) ) -RRB- cord-335975-m6lkrehi 2234 34 ) ) -RRB- cord-335975-m6lkrehi 2234 35 on on IN cord-335975-m6lkrehi 2234 36 prognosis prognosis NN cord-335975-m6lkrehi 2234 37 . . . cord-335975-m6lkrehi 2235 1 Limitation- Limitation- NNP cord-335975-m6lkrehi 2236 1 The the DT cord-335975-m6lkrehi 2236 2 absence absence NN cord-335975-m6lkrehi 2236 3 of of IN cord-335975-m6lkrehi 2236 4 information information NN cord-335975-m6lkrehi 2236 5 about about IN cord-335975-m6lkrehi 2236 6 antibiotic antibiotic JJ cord-335975-m6lkrehi 2236 7 consumption consumption NN cord-335975-m6lkrehi 2236 8 may may MD cord-335975-m6lkrehi 2236 9 partly partly RB cord-335975-m6lkrehi 2236 10 explain explain VB cord-335975-m6lkrehi 2236 11 the the DT cord-335975-m6lkrehi 2236 12 remaining remain VBG cord-335975-m6lkrehi 2236 13 significant significant JJ cord-335975-m6lkrehi 2236 14 center center NN cord-335975-m6lkrehi 2236 15 random random JJ cord-335975-m6lkrehi 2236 16 effect effect NN cord-335975-m6lkrehi 2236 17 in in IN cord-335975-m6lkrehi 2236 18 the the DT cord-335975-m6lkrehi 2236 19 final final JJ cord-335975-m6lkrehi 2236 20 models model NNS cord-335975-m6lkrehi 2236 21 . . . cord-335975-m6lkrehi 2237 1 Conclusion conclusion NN cord-335975-m6lkrehi 2237 2 : : : cord-335975-m6lkrehi 2237 3 in in IN cord-335975-m6lkrehi 2237 4 a a DT cord-335975-m6lkrehi 2237 5 large large JJ cord-335975-m6lkrehi 2237 6 French french JJ cord-335975-m6lkrehi 2237 7 database database NN cord-335975-m6lkrehi 2237 8 , , , cord-335975-m6lkrehi 2237 9 after after IN cord-335975-m6lkrehi 2237 10 adequate adequate JJ cord-335975-m6lkrehi 2237 11 adjustment adjustment NN cord-335975-m6lkrehi 2237 12 on on IN cord-335975-m6lkrehi 2237 13 prognostic prognostic JJ cord-335975-m6lkrehi 2237 14 factors factor NNS cord-335975-m6lkrehi 2237 15 , , , cord-335975-m6lkrehi 2237 16 Resistant Resistant NNP cord-335975-m6lkrehi 2237 17 BGN BGN NNP cord-335975-m6lkrehi 2237 18 - - HYPH cord-335975-m6lkrehi 2237 19 BSI BSI NNP cord-335975-m6lkrehi 2237 20 was be VBD cord-335975-m6lkrehi 2237 21 associated associate VBN cord-335975-m6lkrehi 2237 22 with with IN cord-335975-m6lkrehi 2237 23 a a DT cord-335975-m6lkrehi 2237 24 higher high JJR cord-335975-m6lkrehi 2237 25 ICU ICU NNP cord-335975-m6lkrehi 2237 26 mortality mortality NN cord-335975-m6lkrehi 2237 27 than than IN cord-335975-m6lkrehi 2237 28 susceptible susceptible JJ cord-335975-m6lkrehi 2237 29 one one CD cord-335975-m6lkrehi 2237 30 . . . cord-335975-m6lkrehi 2238 1 The the DT cord-335975-m6lkrehi 2238 2 effect effect NN cord-335975-m6lkrehi 2238 3 was be VBD cord-335975-m6lkrehi 2238 4 mainly mainly RB cord-335975-m6lkrehi 2238 5 due due JJ cord-335975-m6lkrehi 2238 6 to to IN cord-335975-m6lkrehi 2238 7 Eb Eb NNP cord-335975-m6lkrehi 2238 8 3GC 3GC NNP cord-335975-m6lkrehi 2238 9 R. R. NNP cord-335975-m6lkrehi 2238 10 severely severely RB cord-335975-m6lkrehi 2238 11 injured injure VBD cord-335975-m6lkrehi 2238 12 group group NN cord-335975-m6lkrehi 2238 13 versus versus IN cord-335975-m6lkrehi 2238 14 3.1 3.1 CD cord-335975-m6lkrehi 2238 15 ± ± CD cord-335975-m6lkrehi 2238 16 6.4 6.4 CD cord-335975-m6lkrehi 2238 17 days day NNS cord-335975-m6lkrehi 2238 18 for for IN cord-335975-m6lkrehi 2238 19 the the DT cord-335975-m6lkrehi 2238 20 non non JJ cord-335975-m6lkrehi 2238 21 - - JJ cord-335975-m6lkrehi 2238 22 severely severely RB cord-335975-m6lkrehi 2238 23 injured injure VBN cord-335975-m6lkrehi 2238 24 patients patient NNS cord-335975-m6lkrehi 2238 25 ( ( -LRB- cord-335975-m6lkrehi 2238 26 p p NN cord-335975-m6lkrehi 2238 27 < < XX cord-335975-m6lkrehi 2238 28 0.0001 0.0001 CD cord-335975-m6lkrehi 2238 29 ) ) -RRB- cord-335975-m6lkrehi 2238 30 . . . cord-335975-m6lkrehi 2239 1 In in IN cord-335975-m6lkrehi 2239 2 multivariate multivariate JJ cord-335975-m6lkrehi 2239 3 analysis analysis NN cord-335975-m6lkrehi 2239 4 , , , cord-335975-m6lkrehi 2239 5 heart heart NN cord-335975-m6lkrehi 2239 6 rate rate NN cord-335975-m6lkrehi 2239 7 ( ( -LRB- cord-335975-m6lkrehi 2239 8 > > NFP cord-335975-m6lkrehi 2239 9 100 100 CD cord-335975-m6lkrehi 2239 10 min min NN cord-335975-m6lkrehi 2239 11 ) ) -RRB- cord-335975-m6lkrehi 2239 12 and and CC cord-335975-m6lkrehi 2239 13 Vittel Vittel NNP cord-335975-m6lkrehi 2239 14 score score NN cord-335975-m6lkrehi 2239 15 ( ( -LRB- cord-335975-m6lkrehi 2239 16 ≥ ≥ CD cord-335975-m6lkrehi 2239 17 2 2 CD cord-335975-m6lkrehi 2239 18 criterias criteria NNS cord-335975-m6lkrehi 2239 19 ) ) -RRB- cord-335975-m6lkrehi 2239 20 were be VBD cord-335975-m6lkrehi 2239 21 related relate VBN cord-335975-m6lkrehi 2239 22 to to IN cord-335975-m6lkrehi 2239 23 the the DT cord-335975-m6lkrehi 2239 24 probability probability NN cord-335975-m6lkrehi 2239 25 of of IN cord-335975-m6lkrehi 2239 26 belonging belong VBG cord-335975-m6lkrehi 2239 27 to to IN cord-335975-m6lkrehi 2239 28 the the DT cord-335975-m6lkrehi 2239 29 severely severely RB cord-335975-m6lkrehi 2239 30 injured injure VBN cord-335975-m6lkrehi 2239 31 group group NN cord-335975-m6lkrehi 2239 32 ( ( -LRB- cord-335975-m6lkrehi 2239 33 p p NN cord-335975-m6lkrehi 2239 34 = = SYM cord-335975-m6lkrehi 2239 35 0.03 0.03 CD cord-335975-m6lkrehi 2239 36 ) ) -RRB- cord-335975-m6lkrehi 2239 37 . . . cord-335975-m6lkrehi 2240 1 The the DT cord-335975-m6lkrehi 2240 2 24-hour 24-hour JJ cord-335975-m6lkrehi 2240 3 mortality mortality NN cord-335975-m6lkrehi 2240 4 rate rate NN cord-335975-m6lkrehi 2240 5 was be VBD cord-335975-m6lkrehi 2240 6 0.5 0.5 CD cord-335975-m6lkrehi 2240 7 % % NN cord-335975-m6lkrehi 2240 8 in in IN cord-335975-m6lkrehi 2240 9 the the DT cord-335975-m6lkrehi 2240 10 ED ED NNP cord-335975-m6lkrehi 2240 11 and and CC cord-335975-m6lkrehi 2240 12 the the DT cord-335975-m6lkrehi 2240 13 30-day 30-day CD cord-335975-m6lkrehi 2240 14 mortality mortality NN cord-335975-m6lkrehi 2240 15 rate rate NN cord-335975-m6lkrehi 2240 16 was be VBD cord-335975-m6lkrehi 2240 17 1.5 1.5 CD cord-335975-m6lkrehi 2240 18 % % NN cord-335975-m6lkrehi 2240 19 . . . cord-335975-m6lkrehi 2241 1 The the DT cord-335975-m6lkrehi 2241 2 development development NN cord-335975-m6lkrehi 2241 3 of of IN cord-335975-m6lkrehi 2241 4 a a DT cord-335975-m6lkrehi 2241 5 network network NN cord-335975-m6lkrehi 2241 6 in in IN cord-335975-m6lkrehi 2241 7 the the DT cord-335975-m6lkrehi 2241 8 ED ED NNP cord-335975-m6lkrehi 2241 9 hosting host VBG cord-335975-m6lkrehi 2241 10 non non JJ cord-335975-m6lkrehi 2241 11 vital vital JJ cord-335975-m6lkrehi 2241 12 polytraumas polytraumas NNPS cord-335975-m6lkrehi 2241 13 remains remain VBZ cord-335975-m6lkrehi 2241 14 crucial crucial JJ cord-335975-m6lkrehi 2241 15 . . . cord-335975-m6lkrehi 2242 1 Its -PRON- PRP$ cord-335975-m6lkrehi 2242 2 primary primary JJ cord-335975-m6lkrehi 2242 3 goal goal NN cord-335975-m6lkrehi 2242 4 will will MD cord-335975-m6lkrehi 2242 5 be be VB cord-335975-m6lkrehi 2242 6 to to TO cord-335975-m6lkrehi 2242 7 meet meet VB cord-335975-m6lkrehi 2242 8 technical technical JJ cord-335975-m6lkrehi 2242 9 and and CC cord-335975-m6lkrehi 2242 10 time time NN cord-335975-m6lkrehi 2242 11 requirements requirement NNS cord-335975-m6lkrehi 2242 12 and and CC cord-335975-m6lkrehi 2242 13 establish establish VB cord-335975-m6lkrehi 2242 14 in in IN cord-335975-m6lkrehi 2242 15 - - HYPH cord-335975-m6lkrehi 2242 16 hospital hospital NN cord-335975-m6lkrehi 2242 17 triage triage NN cord-335975-m6lkrehi 2242 18 algorithms algorithm NNS cord-335975-m6lkrehi 2242 19 based base VBN cord-335975-m6lkrehi 2242 20 on on IN cord-335975-m6lkrehi 2242 21 clinical clinical JJ cord-335975-m6lkrehi 2242 22 variables variable NNS cord-335975-m6lkrehi 2242 23 , , , cord-335975-m6lkrehi 2242 24 in in IN cord-335975-m6lkrehi 2242 25 order order NN cord-335975-m6lkrehi 2242 26 to to TO cord-335975-m6lkrehi 2242 27 detect detect VB cord-335975-m6lkrehi 2242 28 these these DT cord-335975-m6lkrehi 2242 29 patients patient NNS cord-335975-m6lkrehi 2242 30 at at IN cord-335975-m6lkrehi 2242 31 an an DT cord-335975-m6lkrehi 2242 32 early early JJ cord-335975-m6lkrehi 2242 33 stage stage NN cord-335975-m6lkrehi 2242 34 and and CC cord-335975-m6lkrehi 2242 35 offer offer VB cord-335975-m6lkrehi 2242 36 them -PRON- PRP cord-335975-m6lkrehi 2242 37 priority priority NN cord-335975-m6lkrehi 2242 38 care care NN cord-335975-m6lkrehi 2242 39 in in IN cord-335975-m6lkrehi 2242 40 our -PRON- PRP$ cord-335975-m6lkrehi 2242 41 overcrowded overcrowded JJ cord-335975-m6lkrehi 2242 42 EDs ed NNS cord-335975-m6lkrehi 2242 43 . . . cord-335975-m6lkrehi 2243 1 Introduction introduction NN cord-335975-m6lkrehi 2243 2 : : : cord-335975-m6lkrehi 2244 1 The the DT cord-335975-m6lkrehi 2244 2 trauma trauma NN cord-335975-m6lkrehi 2244 3 of of IN cord-335975-m6lkrehi 2244 4 traffic traffic NN cord-335975-m6lkrehi 2244 5 accidents accident NNS cord-335975-m6lkrehi 2244 6 and and CC cord-335975-m6lkrehi 2244 7 particularly particularly RB cord-335975-m6lkrehi 2244 8 cranial cranial JJ cord-335975-m6lkrehi 2244 9 trauma trauma NN cord-335975-m6lkrehi 2244 10 are be VBP cord-335975-m6lkrehi 2244 11 , , , cord-335975-m6lkrehi 2244 12 due due IN cord-335975-m6lkrehi 2244 13 to to IN cord-335975-m6lkrehi 2244 14 their -PRON- PRP$ cord-335975-m6lkrehi 2244 15 frequency frequency NN cord-335975-m6lkrehi 2244 16 and and CC cord-335975-m6lkrehi 2244 17 severe severe JJ cord-335975-m6lkrehi 2244 18 consequences consequence NNS cord-335975-m6lkrehi 2244 19 in in IN cord-335975-m6lkrehi 2244 20 both both CC cord-335975-m6lkrehi 2244 21 the the DT cord-335975-m6lkrehi 2244 22 short short JJ cord-335975-m6lkrehi 2244 23 and and CC cord-335975-m6lkrehi 2244 24 long long JJ cord-335975-m6lkrehi 2244 25 term term NN cord-335975-m6lkrehi 2244 26 , , , cord-335975-m6lkrehi 2244 27 a a DT cord-335975-m6lkrehi 2244 28 real real JJ cord-335975-m6lkrehi 2244 29 public public JJ cord-335975-m6lkrehi 2244 30 health health NN cord-335975-m6lkrehi 2244 31 scourge scourge NN cord-335975-m6lkrehi 2244 32 on on IN cord-335975-m6lkrehi 2244 33 a a DT cord-335975-m6lkrehi 2244 34 global global JJ cord-335975-m6lkrehi 2244 35 scale scale NN cord-335975-m6lkrehi 2244 36 . . . cord-335975-m6lkrehi 2245 1 Studies study NNS cord-335975-m6lkrehi 2245 2 of of IN cord-335975-m6lkrehi 2245 3 the the DT cord-335975-m6lkrehi 2245 4 epidemiology epidemiology NN cord-335975-m6lkrehi 2245 5 of of IN cord-335975-m6lkrehi 2245 6 cranial cranial JJ cord-335975-m6lkrehi 2245 7 trauma trauma NN cord-335975-m6lkrehi 2245 8 by by IN cord-335975-m6lkrehi 2245 9 traffic traffic NN cord-335975-m6lkrehi 2245 10 accidents accident NNS cord-335975-m6lkrehi 2245 11 and and CC cord-335975-m6lkrehi 2245 12 their -PRON- PRP$ cord-335975-m6lkrehi 2245 13 prognosis prognosis NN cord-335975-m6lkrehi 2245 14 are be VBP cord-335975-m6lkrehi 2245 15 rare rare JJ cord-335975-m6lkrehi 2245 16 at at IN cord-335975-m6lkrehi 2245 17 least least JJS cord-335975-m6lkrehi 2245 18 in in IN cord-335975-m6lkrehi 2245 19 underdeveloped underdeveloped JJ cord-335975-m6lkrehi 2245 20 or or CC cord-335975-m6lkrehi 2245 21 developing develop VBG cord-335975-m6lkrehi 2245 22 countries country NNS cord-335975-m6lkrehi 2245 23 . . . cord-335975-m6lkrehi 2246 1 In in IN cord-335975-m6lkrehi 2246 2 addition addition NN cord-335975-m6lkrehi 2246 3 , , , cord-335975-m6lkrehi 2246 4 the the DT cord-335975-m6lkrehi 2246 5 impact impact NN cord-335975-m6lkrehi 2246 6 of of IN cord-335975-m6lkrehi 2246 7 extracranial extracranial JJ cord-335975-m6lkrehi 2246 8 lesions lesion NNS cord-335975-m6lkrehi 2246 9 on on IN cord-335975-m6lkrehi 2246 10 cranial cranial JJ cord-335975-m6lkrehi 2246 11 trauma trauma NN cord-335975-m6lkrehi 2246 12 prognosis prognosis NN cord-335975-m6lkrehi 2246 13 has have VBZ cord-335975-m6lkrehi 2246 14 long long RB cord-335975-m6lkrehi 2246 15 been be VBN cord-335975-m6lkrehi 2246 16 discussed discuss VBN cord-335975-m6lkrehi 2246 17 . . . cord-335975-m6lkrehi 2247 1 The the DT cord-335975-m6lkrehi 2247 2 purposes purpose NNS cord-335975-m6lkrehi 2247 3 of of IN cord-335975-m6lkrehi 2247 4 our -PRON- PRP$ cord-335975-m6lkrehi 2247 5 study study NN cord-335975-m6lkrehi 2247 6 were be VBD cord-335975-m6lkrehi 2247 7 to to TO cord-335975-m6lkrehi 2247 8 examine examine VB cord-335975-m6lkrehi 2247 9 the the DT cord-335975-m6lkrehi 2247 10 epidemiological epidemiological JJ cord-335975-m6lkrehi 2247 11 aspects aspect NNS cord-335975-m6lkrehi 2247 12 and and CC cord-335975-m6lkrehi 2247 13 to to TO cord-335975-m6lkrehi 2247 14 determine determine VB cord-335975-m6lkrehi 2247 15 the the DT cord-335975-m6lkrehi 2247 16 factors factor NNS cord-335975-m6lkrehi 2247 17 correlated correlate VBN cord-335975-m6lkrehi 2247 18 to to IN cord-335975-m6lkrehi 2247 19 the the DT cord-335975-m6lkrehi 2247 20 immediate immediate JJ cord-335975-m6lkrehi 2247 21 and and CC cord-335975-m6lkrehi 2247 22 distant distant JJ cord-335975-m6lkrehi 2247 23 prognosis prognosis NN cord-335975-m6lkrehi 2247 24 of of IN cord-335975-m6lkrehi 2247 25 isolated isolate VBN cord-335975-m6lkrehi 2247 26 cranial cranial JJ cord-335975-m6lkrehi 2247 27 trauma trauma NN cord-335975-m6lkrehi 2247 28 . . . cord-335975-m6lkrehi 2248 1 Patients patient NNS cord-335975-m6lkrehi 2248 2 and and CC cord-335975-m6lkrehi 2248 3 methods method NNS cord-335975-m6lkrehi 2248 4 : : : cord-335975-m6lkrehi 2248 5 Retrospective retrospective JJ cord-335975-m6lkrehi 2248 6 cohort cohort NN cord-335975-m6lkrehi 2248 7 spread spread VBD cord-335975-m6lkrehi 2248 8 over over IN cord-335975-m6lkrehi 2248 9 4 4 CD cord-335975-m6lkrehi 2248 10 years year NNS cord-335975-m6lkrehi 2248 11 ( ( -LRB- cord-335975-m6lkrehi 2248 12 from from IN cord-335975-m6lkrehi 2248 13 2009 2009 CD cord-335975-m6lkrehi 2248 14 to to IN cord-335975-m6lkrehi 2248 15 2012 2012 CD cord-335975-m6lkrehi 2248 16 ) ) -RRB- cord-335975-m6lkrehi 2248 17 and and CC cord-335975-m6lkrehi 2248 18 including include VBG cord-335975-m6lkrehi 2248 19 242 242 CD cord-335975-m6lkrehi 2248 20 patients patient NNS cord-335975-m6lkrehi 2248 21 with with IN cord-335975-m6lkrehi 2248 22 isolated isolate VBN cord-335975-m6lkrehi 2248 23 Cranial cranial JJ cord-335975-m6lkrehi 2248 24 trauma trauma NN cord-335975-m6lkrehi 2248 25 by by IN cord-335975-m6lkrehi 2248 26 traffic traffic NN cord-335975-m6lkrehi 2248 27 accidents accident NNS cord-335975-m6lkrehi 2248 28 ( ( -LRB- cord-335975-m6lkrehi 2248 29 mean mean VB cord-335975-m6lkrehi 2248 30 age age NN cord-335975-m6lkrehi 2248 31 30.9 30.9 CD cord-335975-m6lkrehi 2248 32 years year NNS cord-335975-m6lkrehi 2248 33 , , , cord-335975-m6lkrehi 2248 34 sex sex NN cord-335975-m6lkrehi 2248 35 ratio-7 ratio-7 NNP cord-335975-m6lkrehi 2248 36 ) ) -RRB- cord-335975-m6lkrehi 2248 37 . . . cord-335975-m6lkrehi 2249 1 We -PRON- PRP cord-335975-m6lkrehi 2249 2 proposed propose VBD cord-335975-m6lkrehi 2249 3 to to TO cord-335975-m6lkrehi 2249 4 study study VB cord-335975-m6lkrehi 2249 5 the the DT cord-335975-m6lkrehi 2249 6 factors factor NNS cord-335975-m6lkrehi 2249 7 correlated correlate VBN cord-335975-m6lkrehi 2249 8 with with IN cord-335975-m6lkrehi 2249 9 a a DT cord-335975-m6lkrehi 2249 10 poor poor JJ cord-335975-m6lkrehi 2249 11 prognosis prognosis NN cord-335975-m6lkrehi 2249 12 in in IN cord-335975-m6lkrehi 2249 13 terms term NNS cord-335975-m6lkrehi 2249 14 of of IN cord-335975-m6lkrehi 2249 15 death death NN cord-335975-m6lkrehi 2249 16 in in IN cord-335975-m6lkrehi 2249 17 hospital hospital NN cord-335975-m6lkrehi 2249 18 and and CC cord-335975-m6lkrehi 2249 19 Glasgow Glasgow NNP cord-335975-m6lkrehi 2249 20 Outcome outcome NN cord-335975-m6lkrehi 2249 21 Scale Scale NNP cord-335975-m6lkrehi 2249 22 ( ( -LRB- cord-335975-m6lkrehi 2249 23 GOS GOS NNP cord-335975-m6lkrehi 2249 24 ) ) -RRB- cord-335975-m6lkrehi 2249 25 at at IN cord-335975-m6lkrehi 2249 26 6 6 CD cord-335975-m6lkrehi 2249 27 months month NNS cord-335975-m6lkrehi 2249 28 unfavorable unfavorable JJ cord-335975-m6lkrehi 2249 29 in in IN cord-335975-m6lkrehi 2249 30 dual dual JJ cord-335975-m6lkrehi 2249 31 analysis analysis NN cord-335975-m6lkrehi 2249 32 ( ( -LRB- cord-335975-m6lkrehi 2249 33 univariate univariate JJ cord-335975-m6lkrehi 2249 34 and and CC cord-335975-m6lkrehi 2249 35 then then RB cord-335975-m6lkrehi 2249 36 multivariate multivariate JJ cord-335975-m6lkrehi 2249 37 ) ) -RRB- cord-335975-m6lkrehi 2249 38 . . . cord-335975-m6lkrehi 2250 1 For for IN cord-335975-m6lkrehi 2250 2 the the DT cord-335975-m6lkrehi 2250 3 GOS GOS NNP cord-335975-m6lkrehi 2250 4 study study NN cord-335975-m6lkrehi 2250 5 , , , cord-335975-m6lkrehi 2250 6 patients patient NNS cord-335975-m6lkrehi 2250 7 were be VBD cord-335975-m6lkrehi 2250 8 divided divide VBN cord-335975-m6lkrehi 2250 9 into into IN cord-335975-m6lkrehi 2250 10 2 2 CD cord-335975-m6lkrehi 2250 11 groups group NNS cord-335975-m6lkrehi 2250 12 - - : cord-335975-m6lkrehi 2250 13 GOS gos NN cord-335975-m6lkrehi 2250 14 favorable favorable JJ cord-335975-m6lkrehi 2250 15 for for IN cord-335975-m6lkrehi 2250 16 patients patient NNS cord-335975-m6lkrehi 2250 17 with with IN cord-335975-m6lkrehi 2250 18 good good JJ cord-335975-m6lkrehi 2250 19 recovery recovery NN cord-335975-m6lkrehi 2250 20 ( ( -LRB- cord-335975-m6lkrehi 2250 21 GOS gos NN cord-335975-m6lkrehi 2250 22 = = SYM cord-335975-m6lkrehi 2250 23 5 5 CD cord-335975-m6lkrehi 2250 24 ) ) -RRB- cord-335975-m6lkrehi 2250 25 , , , cord-335975-m6lkrehi 2250 26 recovery recovery NN cord-335975-m6lkrehi 2250 27 with with IN cord-335975-m6lkrehi 2250 28 a a DT cord-335975-m6lkrehi 2250 29 light light JJ cord-335975-m6lkrehi 2250 30 handicap handicap NN cord-335975-m6lkrehi 2250 31 ( ( -LRB- cord-335975-m6lkrehi 2250 32 GOS gos NN cord-335975-m6lkrehi 2250 33 = = SYM cord-335975-m6lkrehi 2250 34 4 4 CD cord-335975-m6lkrehi 2250 35 ) ) -RRB- cord-335975-m6lkrehi 2250 36 , , , cord-335975-m6lkrehi 2250 37 GOS GOS NNP cord-335975-m6lkrehi 2250 38 unfavorable unfavorable JJ cord-335975-m6lkrehi 2250 39 for for IN cord-335975-m6lkrehi 2250 40 those those DT cord-335975-m6lkrehi 2250 41 having have VBG cord-335975-m6lkrehi 2250 42 survived survive VBN cord-335975-m6lkrehi 2250 43 with with IN cord-335975-m6lkrehi 2250 44 a a DT cord-335975-m6lkrehi 2250 45 severe severe JJ cord-335975-m6lkrehi 2250 46 disability disability NN cord-335975-m6lkrehi 2250 47 ( ( -LRB- cord-335975-m6lkrehi 2250 48 GOS gos NN cord-335975-m6lkrehi 2250 49 = = SYM cord-335975-m6lkrehi 2250 50 3 3 CD cord-335975-m6lkrehi 2250 51 ) ) -RRB- cord-335975-m6lkrehi 2250 52 , , , cord-335975-m6lkrehi 2250 53 a a DT cord-335975-m6lkrehi 2250 54 vegetative vegetative JJ cord-335975-m6lkrehi 2250 55 or or CC cord-335975-m6lkrehi 2250 56 pauci pauci NN cord-335975-m6lkrehi 2250 57 - - HYPH cord-335975-m6lkrehi 2250 58 relational relational JJ cord-335975-m6lkrehi 2250 59 state state NN cord-335975-m6lkrehi 2250 60 ( ( -LRB- cord-335975-m6lkrehi 2250 61 GOS gos NN cord-335975-m6lkrehi 2250 62 = = SYM cord-335975-m6lkrehi 2250 63 2 2 CD cord-335975-m6lkrehi 2250 64 ) ) -RRB- cord-335975-m6lkrehi 2250 65 and and CC cord-335975-m6lkrehi 2250 66 those those DT cord-335975-m6lkrehi 2250 67 who who WP cord-335975-m6lkrehi 2250 68 died die VBD cord-335975-m6lkrehi 2250 69 ( ( -LRB- cord-335975-m6lkrehi 2250 70 GOS GOS NNP cord-335975-m6lkrehi 2250 71 class class NN cord-335975-m6lkrehi 2250 72 1 1 CD cord-335975-m6lkrehi 2250 73 ) ) -RRB- cord-335975-m6lkrehi 2250 74 . . . cord-335975-m6lkrehi 2251 1 Results result NNS cord-335975-m6lkrehi 2251 2 : : : cord-335975-m6lkrehi 2252 1 Hospital hospital NN cord-335975-m6lkrehi 2252 2 mortality mortality NN cord-335975-m6lkrehi 2252 3 was be VBD cord-335975-m6lkrehi 2252 4 26 26 CD cord-335975-m6lkrehi 2252 5 % % NN cord-335975-m6lkrehi 2252 6 and and CC cord-335975-m6lkrehi 2252 7 the the DT cord-335975-m6lkrehi 2252 8 GOS GOS NNP cord-335975-m6lkrehi 2252 9 at at IN cord-335975-m6lkrehi 2252 10 6 6 CD cord-335975-m6lkrehi 2252 11 months month NNS cord-335975-m6lkrehi 2252 12 was be VBD cord-335975-m6lkrehi 2252 13 distributed distribute VBN cord-335975-m6lkrehi 2252 14 as as IN cord-335975-m6lkrehi 2252 15 follows follow VBZ cord-335975-m6lkrehi 2252 16 : : : cord-335975-m6lkrehi 2252 17 death death NN cord-335975-m6lkrehi 2252 18 ( ( -LRB- cord-335975-m6lkrehi 2252 19 27.3 27.3 CD cord-335975-m6lkrehi 2252 20 % % NN cord-335975-m6lkrehi 2252 21 ) ) -RRB- cord-335975-m6lkrehi 2252 22 , , , cord-335975-m6lkrehi 2252 23 vegetative vegetative JJ cord-335975-m6lkrehi 2252 24 state state NN cord-335975-m6lkrehi 2252 25 ( ( -LRB- cord-335975-m6lkrehi 2252 26 2.9 2.9 CD cord-335975-m6lkrehi 2252 27 % % NN cord-335975-m6lkrehi 2252 28 ) ) -RRB- cord-335975-m6lkrehi 2252 29 , , , cord-335975-m6lkrehi 2252 30 severe severe JJ cord-335975-m6lkrehi 2252 31 disability disability NN cord-335975-m6lkrehi 2252 32 ( ( -LRB- cord-335975-m6lkrehi 2252 33 11.2 11.2 CD cord-335975-m6lkrehi 2252 34 % % NN cord-335975-m6lkrehi 2252 35 ) ) -RRB- cord-335975-m6lkrehi 2252 36 , , , cord-335975-m6lkrehi 2252 37 mild mild JJ cord-335975-m6lkrehi 2252 38 disability disability NN cord-335975-m6lkrehi 2252 39 ( ( -LRB- cord-335975-m6lkrehi 2252 40 28 28 CD cord-335975-m6lkrehi 2252 41 % % NN cord-335975-m6lkrehi 2252 42 ) ) -RRB- cord-335975-m6lkrehi 2252 43 and and CC cord-335975-m6lkrehi 2252 44 good good JJ cord-335975-m6lkrehi 2252 45 recovery recovery NN cord-335975-m6lkrehi 2252 46 ( ( -LRB- cord-335975-m6lkrehi 2252 47 30.6 30.6 CD cord-335975-m6lkrehi 2252 48 % % NN cord-335975-m6lkrehi 2252 49 ) ) -RRB- cord-335975-m6lkrehi 2252 50 . . . cord-335975-m6lkrehi 2253 1 The the DT cord-335975-m6lkrehi 2253 2 6-month 6-month CD cord-335975-m6lkrehi 2253 3 GOS GOS NNP cord-335975-m6lkrehi 2253 4 was be VBD cord-335975-m6lkrehi 2253 5 deemed deem VBN cord-335975-m6lkrehi 2253 6 unfavorable unfavorable JJ cord-335975-m6lkrehi 2253 7 in in IN cord-335975-m6lkrehi 2253 8 41.4 41.4 CD cord-335975-m6lkrehi 2253 9 % % NN cord-335975-m6lkrehi 2253 10 of of IN cord-335975-m6lkrehi 2253 11 the the DT cord-335975-m6lkrehi 2253 12 cases case NNS cord-335975-m6lkrehi 2253 13 . . . cord-335975-m6lkrehi 2254 1 Various various JJ cord-335975-m6lkrehi 2254 2 after after IN cord-335975-m6lkrehi 2254 3 effects effect NNS cord-335975-m6lkrehi 2254 4 were be VBD cord-335975-m6lkrehi 2254 5 observed observe VBN cord-335975-m6lkrehi 2254 6 in in IN cord-335975-m6lkrehi 2254 7 survivors survivor NNS cord-335975-m6lkrehi 2254 8 : : : cord-335975-m6lkrehi 2254 9 physical physical JJ cord-335975-m6lkrehi 2254 10 ( ( -LRB- cord-335975-m6lkrehi 2254 11 42 42 CD cord-335975-m6lkrehi 2254 12 % % NN cord-335975-m6lkrehi 2254 13 ) ) -RRB- cord-335975-m6lkrehi 2254 14 dominated dominate VBN cord-335975-m6lkrehi 2254 15 by by IN cord-335975-m6lkrehi 2254 16 headache headache NN cord-335975-m6lkrehi 2254 17 ( ( -LRB- cord-335975-m6lkrehi 2254 18 24.4 24.4 CD cord-335975-m6lkrehi 2254 19 % % NN cord-335975-m6lkrehi 2254 20 ) ) -RRB- cord-335975-m6lkrehi 2254 21 , , , cord-335975-m6lkrehi 2254 22 sleep sleep NN cord-335975-m6lkrehi 2254 23 disorders disorder NNS cord-335975-m6lkrehi 2254 24 ( ( -LRB- cord-335975-m6lkrehi 2254 25 14.2 14.2 CD cord-335975-m6lkrehi 2254 26 % % NN cord-335975-m6lkrehi 2254 27 ) ) -RRB- cord-335975-m6lkrehi 2254 28 and and CC cord-335975-m6lkrehi 2254 29 epilepsy epilepsy NN cord-335975-m6lkrehi 2254 30 ( ( -LRB- cord-335975-m6lkrehi 2254 31 7.2 7.2 CD cord-335975-m6lkrehi 2254 32 % % NN cord-335975-m6lkrehi 2254 33 ) ) -RRB- cord-335975-m6lkrehi 2254 34 ; ; : cord-335975-m6lkrehi 2254 35 memory memory NN cord-335975-m6lkrehi 2254 36 disorders disorder NNS cord-335975-m6lkrehi 2254 37 ( ( -LRB- cord-335975-m6lkrehi 2254 38 27.8 27.8 CD cord-335975-m6lkrehi 2254 39 % % NN cord-335975-m6lkrehi 2254 40 ) ) -RRB- cord-335975-m6lkrehi 2254 41 or or CC cord-335975-m6lkrehi 2254 42 concentration concentration NN cord-335975-m6lkrehi 2254 43 ( ( -LRB- cord-335975-m6lkrehi 2254 44 16.5 16.5 CD cord-335975-m6lkrehi 2254 45 % % NN cord-335975-m6lkrehi 2254 46 ) ) -RRB- cord-335975-m6lkrehi 2254 47 and and CC cord-335975-m6lkrehi 2254 48 finally finally RB cord-335975-m6lkrehi 2254 49 emotional emotional JJ cord-335975-m6lkrehi 2254 50 after after IN cord-335975-m6lkrehi 2254 51 effects effect NNS cord-335975-m6lkrehi 2254 52 ( ( -LRB- cord-335975-m6lkrehi 2254 53 32.4 32.4 CD cord-335975-m6lkrehi 2254 54 % % NN cord-335975-m6lkrehi 2254 55 ) ) -RRB- cord-335975-m6lkrehi 2254 56 with with IN cord-335975-m6lkrehi 2254 57 irritability irritability NN cord-335975-m6lkrehi 2254 58 ( ( -LRB- cord-335975-m6lkrehi 2254 59 30.7 30.7 CD cord-335975-m6lkrehi 2254 60 % % NN cord-335975-m6lkrehi 2254 61 ) ) -RRB- cord-335975-m6lkrehi 2254 62 and and CC cord-335975-m6lkrehi 2254 63 aggressiveness aggressiveness NN cord-335975-m6lkrehi 2254 64 ( ( -LRB- cord-335975-m6lkrehi 2254 65 9.7 9.7 CD cord-335975-m6lkrehi 2254 66 % % NN cord-335975-m6lkrehi 2254 67 ) ) -RRB- cord-335975-m6lkrehi 2254 68 . . . cord-335975-m6lkrehi 2255 1 In in IN cord-335975-m6lkrehi 2255 2 multivariate multivariate JJ cord-335975-m6lkrehi 2255 3 statistical statistical JJ cord-335975-m6lkrehi 2255 4 analysis analysis NN cord-335975-m6lkrehi 2255 5 , , , cord-335975-m6lkrehi 2255 6 independent independent JJ cord-335975-m6lkrehi 2255 7 predictors predictor NNS cord-335975-m6lkrehi 2255 8 of of IN cord-335975-m6lkrehi 2255 9 mortality mortality NN cord-335975-m6lkrehi 2255 10 were be VBD cord-335975-m6lkrehi 2255 11 arterial arterial JJ cord-335975-m6lkrehi 2255 12 hypotension hypotension NN cord-335975-m6lkrehi 2255 13 , , , cord-335975-m6lkrehi 2255 14 hypoxia hypoxia NN cord-335975-m6lkrehi 2255 15 extradural extradural JJ cord-335975-m6lkrehi 2255 16 hematoma hematoma NN cord-335975-m6lkrehi 2255 17 ( ( -LRB- cord-335975-m6lkrehi 2255 18 EDH EDH NNP cord-335975-m6lkrehi 2255 19 ) ) -RRB- cord-335975-m6lkrehi 2255 20 , , , cord-335975-m6lkrehi 2255 21 , , , cord-335975-m6lkrehi 2255 22 acute acute JJ cord-335975-m6lkrehi 2255 23 subdural subdural JJ cord-335975-m6lkrehi 2255 24 hematomas hematoma NNS cord-335975-m6lkrehi 2255 25 ( ( -LRB- cord-335975-m6lkrehi 2255 26 SDH SDH NNP cord-335975-m6lkrehi 2255 27 ) ) -RRB- cord-335975-m6lkrehi 2255 28 , , , cord-335975-m6lkrehi 2255 29 diffuse diffuse VB cord-335975-m6lkrehi 2255 30 axonal axonal JJ cord-335975-m6lkrehi 2255 31 injury injury NN cord-335975-m6lkrehi 2255 32 and and CC cord-335975-m6lkrehi 2255 33 ventilator ventilator NN cord-335975-m6lkrehi 2255 34 associated associate VBD cord-335975-m6lkrehi 2255 35 pneumonia pneumonia NN cord-335975-m6lkrehi 2255 36 . . . cord-335975-m6lkrehi 2256 1 Those those DT cord-335975-m6lkrehi 2256 2 correlated correlate VBN cord-335975-m6lkrehi 2256 3 with with IN cord-335975-m6lkrehi 2256 4 an an DT cord-335975-m6lkrehi 2256 5 unfavorable unfavorable JJ cord-335975-m6lkrehi 2256 6 GOS gos NN cord-335975-m6lkrehi 2256 7 were be VBD cord-335975-m6lkrehi 2256 8 an an DT cord-335975-m6lkrehi 2256 9 age age NN cord-335975-m6lkrehi 2256 10 ≥ ≥ CD cord-335975-m6lkrehi 2256 11 38 38 CD cord-335975-m6lkrehi 2256 12 years year NNS cord-335975-m6lkrehi 2256 13 , , , cord-335975-m6lkrehi 2256 14 hypotension hypotension NN cord-335975-m6lkrehi 2256 15 , , , cord-335975-m6lkrehi 2256 16 cerebral cerebral JJ cord-335975-m6lkrehi 2256 17 edema edema NN cord-335975-m6lkrehi 2256 18 , , , cord-335975-m6lkrehi 2256 19 coma coma NN cord-335975-m6lkrehi 2256 20 duration duration NN cord-335975-m6lkrehi 2256 21 ≥ ≥ CD cord-335975-m6lkrehi 2256 22 5.5 5.5 CD cord-335975-m6lkrehi 2256 23 days day NNS cord-335975-m6lkrehi 2256 24 , , , cord-335975-m6lkrehi 2256 25 EDH EDH NNP cord-335975-m6lkrehi 2256 26 and and CC cord-335975-m6lkrehi 2256 27 H24 H24 NNP cord-335975-m6lkrehi 2256 28 glucose glucose NN cord-335975-m6lkrehi 2256 29 ≥ ≥ CD cord-335975-m6lkrehi 2257 1 7.15 7.15 CD cord-335975-m6lkrehi 2257 2 mmol mmol NNP cord-335975-m6lkrehi 2257 3 / / SYM cord-335975-m6lkrehi 2257 4 l l NN cord-335975-m6lkrehi 2257 5 . . . cord-335975-m6lkrehi 2258 1 Conclusion conclusion NN cord-335975-m6lkrehi 2258 2 : : : cord-335975-m6lkrehi 2259 1 Although although IN cord-335975-m6lkrehi 2259 2 the the DT cord-335975-m6lkrehi 2259 3 short short JJ cord-335975-m6lkrehi 2259 4 - - HYPH cord-335975-m6lkrehi 2259 5 term term NN cord-335975-m6lkrehi 2259 6 prognosis prognosis NN cord-335975-m6lkrehi 2259 7 of of IN cord-335975-m6lkrehi 2259 8 head head NN cord-335975-m6lkrehi 2259 9 trauma trauma NN cord-335975-m6lkrehi 2259 10 seems seem VBZ cord-335975-m6lkrehi 2259 11 to to TO cord-335975-m6lkrehi 2259 12 be be VB cord-335975-m6lkrehi 2259 13 improved improve VBN cord-335975-m6lkrehi 2259 14 at at IN cord-335975-m6lkrehi 2259 15 present present NN cord-335975-m6lkrehi 2259 16 , , , cord-335975-m6lkrehi 2259 17 the the DT cord-335975-m6lkrehi 2259 18 long long JJ cord-335975-m6lkrehi 2259 19 - - HYPH cord-335975-m6lkrehi 2259 20 term term NN cord-335975-m6lkrehi 2259 21 consequences consequence NNS cord-335975-m6lkrehi 2259 22 of of IN cord-335975-m6lkrehi 2259 23 cranial cranial JJ cord-335975-m6lkrehi 2259 24 trauma trauma NN cord-335975-m6lkrehi 2259 25 remain remain VBP cord-335975-m6lkrehi 2259 26 fairly fairly RB cord-335975-m6lkrehi 2259 27 frequent frequent JJ cord-335975-m6lkrehi 2259 28 , , , cord-335975-m6lkrehi 2259 29 and and CC cord-335975-m6lkrehi 2259 30 often often RB cord-335975-m6lkrehi 2259 31 underestimated underestimate VBD cord-335975-m6lkrehi 2259 32 , , , cord-335975-m6lkrehi 2259 33 which which WDT cord-335975-m6lkrehi 2259 34 underlines underline VBZ cord-335975-m6lkrehi 2259 35 the the DT cord-335975-m6lkrehi 2259 36 importance importance NN cord-335975-m6lkrehi 2259 37 of of IN cord-335975-m6lkrehi 2259 38 their -PRON- PRP$ cord-335975-m6lkrehi 2259 39 screening screening NN cord-335975-m6lkrehi 2259 40 and and CC cord-335975-m6lkrehi 2259 41 their -PRON- PRP$ cord-335975-m6lkrehi 2259 42 proper proper JJ cord-335975-m6lkrehi 2259 43 care care NN cord-335975-m6lkrehi 2259 44 . . . cord-335975-m6lkrehi 2260 1 The the DT cord-335975-m6lkrehi 2260 2 average average JJ cord-335975-m6lkrehi 2260 3 age age NN cord-335975-m6lkrehi 2260 4 of of IN cord-335975-m6lkrehi 2260 5 the the DT cord-335975-m6lkrehi 2260 6 survivors survivor NNS cord-335975-m6lkrehi 2260 7 ( ( -LRB- cord-335975-m6lkrehi 2260 8 30.83 30.83 CD cord-335975-m6lkrehi 2260 9 ± ± CD cord-335975-m6lkrehi 2260 10 13.08 13.08 CD cord-335975-m6lkrehi 2260 11 years year NNS cord-335975-m6lkrehi 2260 12 ) ) -RRB- cord-335975-m6lkrehi 2260 13 was be VBD cord-335975-m6lkrehi 2260 14 lower low JJR cord-335975-m6lkrehi 2260 15 than than IN cord-335975-m6lkrehi 2260 16 the the DT cord-335975-m6lkrehi 2260 17 mean mean JJ cord-335975-m6lkrehi 2260 18 age age NN cord-335975-m6lkrehi 2260 19 of of IN cord-335975-m6lkrehi 2260 20 the the DT cord-335975-m6lkrehi 2260 21 deceased deceased JJ cord-335975-m6lkrehi 2260 22 ( ( -LRB- cord-335975-m6lkrehi 2260 23 36.81 36.81 CD cord-335975-m6lkrehi 2260 24 ± ± CD cord-335975-m6lkrehi 2260 25 16.68 16.68 CD cord-335975-m6lkrehi 2260 26 ) ) -RRB- cord-335975-m6lkrehi 2260 27 . . . cord-335975-m6lkrehi 2261 1 RA RA NNP cord-335975-m6lkrehi 2261 2 was be VBD cord-335975-m6lkrehi 2261 3 the the DT cord-335975-m6lkrehi 2261 4 cause cause NN cord-335975-m6lkrehi 2261 5 of of IN cord-335975-m6lkrehi 2261 6 the the DT cord-335975-m6lkrehi 2261 7 trauma trauma NN cord-335975-m6lkrehi 2261 8 in in IN cord-335975-m6lkrehi 2261 9 76 76 CD cord-335975-m6lkrehi 2261 10 % % NN cord-335975-m6lkrehi 2261 11 of of IN cord-335975-m6lkrehi 2261 12 the the DT cord-335975-m6lkrehi 2261 13 cases case NNS cord-335975-m6lkrehi 2261 14 followed follow VBN cord-335975-m6lkrehi 2261 15 by by IN cord-335975-m6lkrehi 2261 16 the the DT cord-335975-m6lkrehi 2261 17 fall fall NN cord-335975-m6lkrehi 2261 18 found find VBD cord-335975-m6lkrehi 2261 19 cat cat NN cord-335975-m6lkrehi 2261 20 17 17 CD cord-335975-m6lkrehi 2261 21 % % NN cord-335975-m6lkrehi 2261 22 of of IN cord-335975-m6lkrehi 2261 23 the the DT cord-335975-m6lkrehi 2261 24 patients patient NNS cord-335975-m6lkrehi 2261 25 . . . cord-335975-m6lkrehi 2262 1 Prehospital Prehospital NNP cord-335975-m6lkrehi 2262 2 care care VBP cord-335975-m6lkrehi 2262 3 only only RB cord-335975-m6lkrehi 2262 4 concerned concern VBD cord-335975-m6lkrehi 2262 5 4 4 CD cord-335975-m6lkrehi 2262 6 % % NN cord-335975-m6lkrehi 2262 7 of of IN cord-335975-m6lkrehi 2262 8 patients patient NNS cord-335975-m6lkrehi 2262 9 . . . cord-335975-m6lkrehi 2263 1 The the DT cord-335975-m6lkrehi 2263 2 univariate univariate JJ cord-335975-m6lkrehi 2263 3 analysis analysis NN cord-335975-m6lkrehi 2263 4 showed show VBD cord-335975-m6lkrehi 2263 5 that that IN cord-335975-m6lkrehi 2263 6 the the DT cord-335975-m6lkrehi 2263 7 main main JJ cord-335975-m6lkrehi 2263 8 factors factor NNS cord-335975-m6lkrehi 2263 9 of of IN cord-335975-m6lkrehi 2263 10 occurrence occurrence NN cord-335975-m6lkrehi 2263 11 of of IN cord-335975-m6lkrehi 2263 12 death death NN cord-335975-m6lkrehi 2263 13 were be VBD cord-335975-m6lkrehi 2263 14 age age NN cord-335975-m6lkrehi 2263 15 ( ( -LRB- cord-335975-m6lkrehi 2263 16 p p NN cord-335975-m6lkrehi 2263 17 = = SYM cord-335975-m6lkrehi 2263 18 0.02 0.02 CD cord-335975-m6lkrehi 2263 19 ) ) -RRB- cord-335975-m6lkrehi 2263 20 , , , cord-335975-m6lkrehi 2263 21 glasgow glasgow NNP cord-335975-m6lkrehi 2263 22 score score NNP cord-335975-m6lkrehi 2263 23 ( ( -LRB- cord-335975-m6lkrehi 2263 24 p p NN cord-335975-m6lkrehi 2263 25 = = SYM cord-335975-m6lkrehi 2263 26 0.0001 0.0001 CD cord-335975-m6lkrehi 2263 27 ) ) -RRB- cord-335975-m6lkrehi 2263 28 anisocoria anisocoria NNP cord-335975-m6lkrehi 2263 29 ( ( -LRB- cord-335975-m6lkrehi 2263 30 p p NN cord-335975-m6lkrehi 2263 31 = = SYM cord-335975-m6lkrehi 2263 32 0.0009 0.0009 CD cord-335975-m6lkrehi 2263 33 ) ) -RRB- cord-335975-m6lkrehi 2263 34 , , , cord-335975-m6lkrehi 2263 35 shock shock NN cord-335975-m6lkrehi 2263 36 ( ( -LRB- cord-335975-m6lkrehi 2263 37 p p NN cord-335975-m6lkrehi 2263 38 = = SYM cord-335975-m6lkrehi 2263 39 0.002 0.002 CD cord-335975-m6lkrehi 2263 40 ) ) -RRB- cord-335975-m6lkrehi 2263 41 26 26 CD cord-335975-m6lkrehi 2263 42 % % NN cord-335975-m6lkrehi 2263 43 of of IN cord-335975-m6lkrehi 2263 44 deaths death NNS cord-335975-m6lkrehi 2263 45 were be VBD cord-335975-m6lkrehi 2263 46 due due JJ cord-335975-m6lkrehi 2263 47 to to IN cord-335975-m6lkrehi 2263 48 intracranial intracranial JJ cord-335975-m6lkrehi 2263 49 hypertension hypertension NN cord-335975-m6lkrehi 2263 50 , , , cord-335975-m6lkrehi 2263 51 haemorrhagic haemorrhagic JJ cord-335975-m6lkrehi 2263 52 shock shock NN cord-335975-m6lkrehi 2263 53 in in IN cord-335975-m6lkrehi 2263 54 15 15 CD cord-335975-m6lkrehi 2263 55 % % NN cord-335975-m6lkrehi 2263 56 of of IN cord-335975-m6lkrehi 2263 57 patients patient NNS cord-335975-m6lkrehi 2263 58 and and CC cord-335975-m6lkrehi 2263 59 ARDS ARDS NNP cord-335975-m6lkrehi 2263 60 in in IN cord-335975-m6lkrehi 2263 61 7 7 CD cord-335975-m6lkrehi 2263 62 % % NN cord-335975-m6lkrehi 2263 63 of of IN cord-335975-m6lkrehi 2263 64 polytrauma polytrauma NN cord-335975-m6lkrehi 2263 65 patients patient NNS cord-335975-m6lkrehi 2263 66 . . . cord-335975-m6lkrehi 2264 1 Conclusion conclusion NN cord-335975-m6lkrehi 2264 2 : : : cord-335975-m6lkrehi 2265 1 The the DT cord-335975-m6lkrehi 2265 2 management management NN cord-335975-m6lkrehi 2265 3 of of IN cord-335975-m6lkrehi 2265 4 polytrauma polytrauma NNP cord-335975-m6lkrehi 2265 5 can can MD cord-335975-m6lkrehi 2265 6 not not RB cord-335975-m6lkrehi 2265 7 be be VB cord-335975-m6lkrehi 2265 8 improvised improvise VBN cord-335975-m6lkrehi 2265 9 . . . cord-335975-m6lkrehi 2266 1 The the DT cord-335975-m6lkrehi 2266 2 medical medical JJ cord-335975-m6lkrehi 2266 3 teams team NNS cord-335975-m6lkrehi 2266 4 must must MD cord-335975-m6lkrehi 2266 5 be be VB cord-335975-m6lkrehi 2266 6 coordinated coordinate VBN cord-335975-m6lkrehi 2266 7 by by IN cord-335975-m6lkrehi 2266 8 an an DT cord-335975-m6lkrehi 2266 9 emergency emergency NN cord-335975-m6lkrehi 2266 10 physician physician NN cord-335975-m6lkrehi 2266 11 in in IN cord-335975-m6lkrehi 2266 12 prehospital prehospital NNP cord-335975-m6lkrehi 2266 13 , , , cord-335975-m6lkrehi 2266 14 a a DT cord-335975-m6lkrehi 2266 15 doctor doctor NN cord-335975-m6lkrehi 2266 16 anesthesiologist anesthesiologist NN cord-335975-m6lkrehi 2266 17 - - HYPH cord-335975-m6lkrehi 2266 18 resuscitator resuscitator NN cord-335975-m6lkrehi 2266 19 at at IN cord-335975-m6lkrehi 2266 20 the the DT cord-335975-m6lkrehi 2266 21 reception reception NN cord-335975-m6lkrehi 2266 22 . . . cord-335975-m6lkrehi 2267 1 Some some DT cord-335975-m6lkrehi 2267 2 systematic systematic JJ cord-335975-m6lkrehi 2267 3 gestures gesture NNS cord-335975-m6lkrehi 2267 4 such such JJ cord-335975-m6lkrehi 2267 5 as as IN cord-335975-m6lkrehi 2267 6 preparation preparation NN cord-335975-m6lkrehi 2267 7 of of IN cord-335975-m6lkrehi 2267 8 the the DT cord-335975-m6lkrehi 2267 9 reception reception NN cord-335975-m6lkrehi 2267 10 allow allow VB cord-335975-m6lkrehi 2267 11 to to TO cord-335975-m6lkrehi 2267 12 optimize optimize VB cord-335975-m6lkrehi 2267 13 the the DT cord-335975-m6lkrehi 2267 14 management management NN cord-335975-m6lkrehi 2267 15 of of IN cord-335975-m6lkrehi 2267 16 the the DT cord-335975-m6lkrehi 2267 17 time time NN cord-335975-m6lkrehi 2267 18 . . . cord-335975-m6lkrehi 2268 1 Introduction introduction NN cord-335975-m6lkrehi 2268 2 : : : cord-335975-m6lkrehi 2269 1 Benign benign JJ cord-335975-m6lkrehi 2269 2 cranial cranial JJ cord-335975-m6lkrehi 2269 3 trauma trauma NN cord-335975-m6lkrehi 2269 4 is be VBZ cord-335975-m6lkrehi 2269 5 a a DT cord-335975-m6lkrehi 2269 6 major major JJ cord-335975-m6lkrehi 2269 7 public public JJ cord-335975-m6lkrehi 2269 8 health health NN cord-335975-m6lkrehi 2269 9 problem problem NN cord-335975-m6lkrehi 2269 10 due due JJ cord-335975-m6lkrehi 2269 11 to to IN cord-335975-m6lkrehi 2269 12 both both CC cord-335975-m6lkrehi 2269 13 its -PRON- PRP$ cord-335975-m6lkrehi 2269 14 frequency frequency NN cord-335975-m6lkrehi 2269 15 and and CC cord-335975-m6lkrehi 2269 16 the the DT cord-335975-m6lkrehi 2269 17 health health NN cord-335975-m6lkrehi 2269 18 costs cost NNS cord-335975-m6lkrehi 2269 19 it -PRON- PRP cord-335975-m6lkrehi 2269 20 creates create VBZ cord-335975-m6lkrehi 2269 21 . . . cord-335975-m6lkrehi 2270 1 The the DT cord-335975-m6lkrehi 2270 2 aim aim NN cord-335975-m6lkrehi 2270 3 of of IN cord-335975-m6lkrehi 2270 4 this this DT cord-335975-m6lkrehi 2270 5 study study NN cord-335975-m6lkrehi 2270 6 was be VBD cord-335975-m6lkrehi 2270 7 to to TO cord-335975-m6lkrehi 2270 8 identify identify VB cord-335975-m6lkrehi 2270 9 relevant relevant JJ cord-335975-m6lkrehi 2270 10 clinical clinical JJ cord-335975-m6lkrehi 2270 11 factors factor NNS cord-335975-m6lkrehi 2270 12 that that WDT cord-335975-m6lkrehi 2270 13 could could MD cord-335975-m6lkrehi 2270 14 predict predict VB cord-335975-m6lkrehi 2270 15 the the DT cord-335975-m6lkrehi 2270 16 achievement achievement NN cord-335975-m6lkrehi 2270 17 of of IN cord-335975-m6lkrehi 2270 18 brain brain NN cord-335975-m6lkrehi 2270 19 CT CT NNP cord-335975-m6lkrehi 2270 20 and and CC cord-335975-m6lkrehi 2270 21 situations situation NNS cord-335975-m6lkrehi 2270 22 at at IN cord-335975-m6lkrehi 2270 23 risk risk NN cord-335975-m6lkrehi 2270 24 for for IN cord-335975-m6lkrehi 2270 25 neurosurgical neurosurgical JJ cord-335975-m6lkrehi 2270 26 care care NN cord-335975-m6lkrehi 2270 27 and and CC cord-335975-m6lkrehi 2270 28 for for IN cord-335975-m6lkrehi 2270 29 which which WDT cord-335975-m6lkrehi 2270 30 CT CT NNP cord-335975-m6lkrehi 2270 31 was be VBD cord-335975-m6lkrehi 2270 32 a a DT cord-335975-m6lkrehi 2270 33 necessity necessity NN cord-335975-m6lkrehi 2270 34 . . . cord-335975-m6lkrehi 2271 1 Patients patient NNS cord-335975-m6lkrehi 2271 2 and and CC cord-335975-m6lkrehi 2271 3 methods method NNS cord-335975-m6lkrehi 2271 4 : : : cord-335975-m6lkrehi 2271 5 This this DT cord-335975-m6lkrehi 2271 6 is be VBZ cord-335975-m6lkrehi 2271 7 a a DT cord-335975-m6lkrehi 2271 8 24 24 CD cord-335975-m6lkrehi 2271 9 month month NN cord-335975-m6lkrehi 2271 10 prospective prospective JJ cord-335975-m6lkrehi 2271 11 study study NN cord-335975-m6lkrehi 2271 12 , , , cord-335975-m6lkrehi 2271 13 including include VBG cord-335975-m6lkrehi 2271 14 404 404 CD cord-335975-m6lkrehi 2271 15 patients patient NNS cord-335975-m6lkrehi 2271 16 with with IN cord-335975-m6lkrehi 2271 17 benign benign JJ cord-335975-m6lkrehi 2271 18 traumatic traumatic JJ cord-335975-m6lkrehi 2271 19 brain brain NN cord-335975-m6lkrehi 2271 20 injury injury NN cord-335975-m6lkrehi 2272 1 ( ( -LRB- cord-335975-m6lkrehi 2272 2 Glasgow Glasgow NNP cord-335975-m6lkrehi 2272 3 coma coma NN cord-335975-m6lkrehi 2272 4 score score NN cord-335975-m6lkrehi 2272 5 GCS GCS NNP cord-335975-m6lkrehi 2272 6 ≥ ≥ NNP cord-335975-m6lkrehi 2272 7 13 13 CD cord-335975-m6lkrehi 2272 8 ) ) -RRB- cord-335975-m6lkrehi 2272 9 , , , cord-335975-m6lkrehi 2272 10 patients patient NNS cord-335975-m6lkrehi 2272 11 under under IN cord-335975-m6lkrehi 2272 12 16 16 CD cord-335975-m6lkrehi 2272 13 years year NNS cord-335975-m6lkrehi 2272 14 of of IN cord-335975-m6lkrehi 2272 15 age age NN cord-335975-m6lkrehi 2272 16 and and CC cord-335975-m6lkrehi 2272 17 patients patient NNS cord-335975-m6lkrehi 2272 18 with with IN cord-335975-m6lkrehi 2272 19 GCS GCS NNP cord-335975-m6lkrehi 2272 20 < < XX cord-335975-m6lkrehi 2272 21 13 13 CD cord-335975-m6lkrehi 2272 22 were be VBD cord-335975-m6lkrehi 2272 23 excluded exclude VBN cord-335975-m6lkrehi 2272 24 . . . cord-335975-m6lkrehi 2273 1 Epidemiological epidemiological JJ cord-335975-m6lkrehi 2273 2 , , , cord-335975-m6lkrehi 2273 3 clinical clinical JJ cord-335975-m6lkrehi 2273 4 , , , cord-335975-m6lkrehi 2273 5 paraclinical paraclinical JJ cord-335975-m6lkrehi 2273 6 , , , cord-335975-m6lkrehi 2273 7 therapeutic therapeutic JJ cord-335975-m6lkrehi 2273 8 and and CC cord-335975-m6lkrehi 2273 9 evolutionary evolutionary JJ cord-335975-m6lkrehi 2273 10 parameters parameter NNS cord-335975-m6lkrehi 2273 11 were be VBD cord-335975-m6lkrehi 2273 12 studied study VBN cord-335975-m6lkrehi 2273 13 . . . cord-335975-m6lkrehi 2274 1 A a DT cord-335975-m6lkrehi 2274 2 multivariate multivariate JJ cord-335975-m6lkrehi 2274 3 and and CC cord-335975-m6lkrehi 2274 4 univariate univariate JJ cord-335975-m6lkrehi 2274 5 statistical statistical JJ cord-335975-m6lkrehi 2274 6 study study NN cord-335975-m6lkrehi 2274 7 was be VBD cord-335975-m6lkrehi 2274 8 carried carry VBN cord-335975-m6lkrehi 2274 9 out out RP cord-335975-m6lkrehi 2274 10 to to TO cord-335975-m6lkrehi 2274 11 reveal reveal VB cord-335975-m6lkrehi 2274 12 the the DT cord-335975-m6lkrehi 2274 13 predictive predictive JJ cord-335975-m6lkrehi 2274 14 factors factor NNS cord-335975-m6lkrehi 2274 15 of of IN cord-335975-m6lkrehi 2274 16 a a DT cord-335975-m6lkrehi 2274 17 CT CT NNP cord-335975-m6lkrehi 2274 18 anomaly anomaly NN cord-335975-m6lkrehi 2274 19 and and CC cord-335975-m6lkrehi 2274 20 the the DT cord-335975-m6lkrehi 2274 21 predictive predictive JJ cord-335975-m6lkrehi 2274 22 factors factor NNS cord-335975-m6lkrehi 2274 23 for for IN cord-335975-m6lkrehi 2274 24 the the DT cord-335975-m6lkrehi 2274 25 neurosurgical neurosurgical JJ cord-335975-m6lkrehi 2274 26 care care NN cord-335975-m6lkrehi 2274 27 . . . cord-335975-m6lkrehi 2275 1 Data datum NNS cord-335975-m6lkrehi 2275 2 were be VBD cord-335975-m6lkrehi 2275 3 entered enter VBN cord-335975-m6lkrehi 2275 4 and and CC cord-335975-m6lkrehi 2275 5 analyzed analyze VBN cord-335975-m6lkrehi 2275 6 using use VBG cord-335975-m6lkrehi 2275 7 SPSS SPSS NNP cord-335975-m6lkrehi 2275 8 16.0 16.0 CD cord-335975-m6lkrehi 2275 9 and and CC cord-335975-m6lkrehi 2275 10 Excel Excel NNP cord-335975-m6lkrehi 2275 11 2007 2007 CD cord-335975-m6lkrehi 2275 12 software software NN cord-335975-m6lkrehi 2275 13 . . . cord-335975-m6lkrehi 2276 1 Results result NNS cord-335975-m6lkrehi 2276 2 : : : cord-335975-m6lkrehi 2277 1 The the DT cord-335975-m6lkrehi 2277 2 average average JJ cord-335975-m6lkrehi 2277 3 age age NN cord-335975-m6lkrehi 2277 4 of of IN cord-335975-m6lkrehi 2277 5 patients patient NNS cord-335975-m6lkrehi 2277 6 was be VBD cord-335975-m6lkrehi 2277 7 34 34 CD cord-335975-m6lkrehi 2277 8 years year NNS cord-335975-m6lkrehi 2277 9 with with IN cord-335975-m6lkrehi 2277 10 a a DT cord-335975-m6lkrehi 2277 11 predominance predominance NN cord-335975-m6lkrehi 2277 12 of of IN cord-335975-m6lkrehi 2277 13 male male NN cord-335975-m6lkrehi 2277 14 , , , cord-335975-m6lkrehi 2277 15 and and CC cord-335975-m6lkrehi 2277 16 sex sex NN cord-335975-m6lkrehi 2277 17 ratio ratio NN cord-335975-m6lkrehi 2277 18 of of IN cord-335975-m6lkrehi 2277 19 4.05 4.05 CD cord-335975-m6lkrehi 2277 20 . . . cord-335975-m6lkrehi 2278 1 The the DT cord-335975-m6lkrehi 2278 2 cause cause NN cord-335975-m6lkrehi 2278 3 of of IN cord-335975-m6lkrehi 2278 4 the the DT cord-335975-m6lkrehi 2278 5 BTB BTB NNP cord-335975-m6lkrehi 2278 6 was be VBD cord-335975-m6lkrehi 2278 7 mainly mainly RB cord-335975-m6lkrehi 2278 8 represented represent VBN cord-335975-m6lkrehi 2278 9 by by IN cord-335975-m6lkrehi 2278 10 the the DT cord-335975-m6lkrehi 2278 11 accidents accident NNS cord-335975-m6lkrehi 2278 12 of of IN cord-335975-m6lkrehi 2278 13 the the DT cord-335975-m6lkrehi 2278 14 public public JJ cord-335975-m6lkrehi 2278 15 road road NN cord-335975-m6lkrehi 2278 16 in in IN cord-335975-m6lkrehi 2278 17 73.27 73.27 CD cord-335975-m6lkrehi 2278 18 % % NN cord-335975-m6lkrehi 2278 19 of of IN cord-335975-m6lkrehi 2278 20 the the DT cord-335975-m6lkrehi 2278 21 cases case NNS cord-335975-m6lkrehi 2278 22 . . . cord-335975-m6lkrehi 2279 1 28.22 28.22 CD cord-335975-m6lkrehi 2279 2 % % NN cord-335975-m6lkrehi 2279 3 of of IN cord-335975-m6lkrehi 2279 4 the the DT cord-335975-m6lkrehi 2279 5 patients patient NNS cord-335975-m6lkrehi 2279 6 were be VBD cord-335975-m6lkrehi 2279 7 asymptomatic asymptomatic JJ cord-335975-m6lkrehi 2279 8 , , , cord-335975-m6lkrehi 2279 9 the the DT cord-335975-m6lkrehi 2279 10 most most RBS cord-335975-m6lkrehi 2279 11 common common JJ cord-335975-m6lkrehi 2279 12 symptomatology symptomatology NN cord-335975-m6lkrehi 2279 13 was be VBD cord-335975-m6lkrehi 2279 14 dominated dominate VBN cord-335975-m6lkrehi 2279 15 by by IN cord-335975-m6lkrehi 2279 16 the the DT cord-335975-m6lkrehi 2279 17 initial initial JJ cord-335975-m6lkrehi 2279 18 loss loss NN cord-335975-m6lkrehi 2279 19 of of IN cord-335975-m6lkrehi 2279 20 consciousness consciousness NN cord-335975-m6lkrehi 2279 21 ( ( -LRB- cord-335975-m6lkrehi 2279 22 52.72 52.72 CD cord-335975-m6lkrehi 2279 23 % % NN cord-335975-m6lkrehi 2279 24 ) ) -RRB- cord-335975-m6lkrehi 2279 25 , , , cord-335975-m6lkrehi 2279 26 headache headache NN cord-335975-m6lkrehi 2279 27 ( ( -LRB- cord-335975-m6lkrehi 2279 28 35.64 35.64 CD cord-335975-m6lkrehi 2279 29 % % NN cord-335975-m6lkrehi 2279 30 ) ) -RRB- cord-335975-m6lkrehi 2279 31 . . . cord-335975-m6lkrehi 2280 1 The the DT cord-335975-m6lkrehi 2280 2 Glasgow Glasgow NNP cord-335975-m6lkrehi 2280 3 Coma Coma NNP cord-335975-m6lkrehi 2280 4 Score Score NNP cord-335975-m6lkrehi 2280 5 was be VBD cord-335975-m6lkrehi 2280 6 distributed distribute VBN cord-335975-m6lkrehi 2280 7 as as IN cord-335975-m6lkrehi 2280 8 follows follow VBZ cord-335975-m6lkrehi 2280 9 - - : cord-335975-m6lkrehi 2280 10 GCS GCS NNP cord-335975-m6lkrehi 2280 11 15 15 CD cord-335975-m6lkrehi 2280 12 ( ( -LRB- cord-335975-m6lkrehi 2280 13 54.95 54.95 CD cord-335975-m6lkrehi 2280 14 % % NN cord-335975-m6lkrehi 2280 15 ) ) -RRB- cord-335975-m6lkrehi 2280 16 , , , cord-335975-m6lkrehi 2280 17 GCS GCS NNP cord-335975-m6lkrehi 2280 18 14 14 CD cord-335975-m6lkrehi 2280 19 ( ( -LRB- cord-335975-m6lkrehi 2280 20 35.9 35.9 CD cord-335975-m6lkrehi 2280 21 % % NN cord-335975-m6lkrehi 2280 22 ) ) -RRB- cord-335975-m6lkrehi 2280 23 and and CC cord-335975-m6lkrehi 2280 24 13 13 CD cord-335975-m6lkrehi 2280 25 ( ( -LRB- cord-335975-m6lkrehi 2280 26 9.15 9.15 CD cord-335975-m6lkrehi 2280 27 % % NN cord-335975-m6lkrehi 2280 28 ) ) -RRB- cord-335975-m6lkrehi 2280 29 . . . cord-335975-m6lkrehi 2281 1 38.9 38.9 CD cord-335975-m6lkrehi 2281 2 % % NN cord-335975-m6lkrehi 2281 3 of of IN cord-335975-m6lkrehi 2281 4 patients patient NNS cord-335975-m6lkrehi 2281 5 had have VBD cord-335975-m6lkrehi 2281 6 clinical clinical JJ cord-335975-m6lkrehi 2281 7 signs sign NNS cord-335975-m6lkrehi 2281 8 of of IN cord-335975-m6lkrehi 2281 9 trauma trauma NN cord-335975-m6lkrehi 2281 10 to to IN cord-335975-m6lkrehi 2281 11 the the DT cord-335975-m6lkrehi 2281 12 skulland skulland NN cord-335975-m6lkrehi 2281 13 or or CC cord-335975-m6lkrehi 2281 14 face face NN cord-335975-m6lkrehi 2281 15 . . . cord-335975-m6lkrehi 2282 1 Brain Brain NNP cord-335975-m6lkrehi 2282 2 CT CT NNP cord-335975-m6lkrehi 2282 3 was be VBD cord-335975-m6lkrehi 2282 4 performed perform VBN cord-335975-m6lkrehi 2282 5 in in IN cord-335975-m6lkrehi 2282 6 88.4 88.4 CD cord-335975-m6lkrehi 2282 7 % % NN cord-335975-m6lkrehi 2282 8 of of IN cord-335975-m6lkrehi 2282 9 patients patient NNS cord-335975-m6lkrehi 2282 10 , , , cord-335975-m6lkrehi 2282 11 and and CC cord-335975-m6lkrehi 2282 12 25.5 25.5 CD cord-335975-m6lkrehi 2282 13 % % NN cord-335975-m6lkrehi 2282 14 had have VBD cord-335975-m6lkrehi 2282 15 abnormal abnormal JJ cord-335975-m6lkrehi 2282 16 CT CT NNP cord-335975-m6lkrehi 2282 17 . . . cord-335975-m6lkrehi 2283 1 The the DT cord-335975-m6lkrehi 2283 2 use use NN cord-335975-m6lkrehi 2283 3 of of IN cord-335975-m6lkrehi 2283 4 neurosurgical neurosurgical JJ cord-335975-m6lkrehi 2283 5 care care NN cord-335975-m6lkrehi 2283 6 was be VBD cord-335975-m6lkrehi 2283 7 of of IN cord-335975-m6lkrehi 2283 8 the the DT cord-335975-m6lkrehi 2283 9 order order NN cord-335975-m6lkrehi 2283 10 of of IN cord-335975-m6lkrehi 2283 11 3.22 3.22 CD cord-335975-m6lkrehi 2283 12 % % NN cord-335975-m6lkrehi 2283 13 . . . cord-335975-m6lkrehi 2284 1 In in IN cord-335975-m6lkrehi 2284 2 univariate univariate JJ cord-335975-m6lkrehi 2284 3 analysis analysis NN cord-335975-m6lkrehi 2284 4 - - , cord-335975-m6lkrehi 2284 5 the the DT cord-335975-m6lkrehi 2284 6 predictive predictive JJ cord-335975-m6lkrehi 2284 7 factors factor NNS cord-335975-m6lkrehi 2284 8 for for IN cord-335975-m6lkrehi 2284 9 a a DT cord-335975-m6lkrehi 2284 10 CT CT NNP cord-335975-m6lkrehi 2284 11 abnormality abnormality NN cord-335975-m6lkrehi 2284 12 were be VBD cord-335975-m6lkrehi 2284 13 the the DT cord-335975-m6lkrehi 2284 14 Intoxication intoxication NN cord-335975-m6lkrehi 2284 15 during during IN cord-335975-m6lkrehi 2284 16 the the DT cord-335975-m6lkrehi 2284 17 brain brain NN cord-335975-m6lkrehi 2284 18 trauma trauma NN cord-335975-m6lkrehi 2284 19 , , , cord-335975-m6lkrehi 2284 20 the the DT cord-335975-m6lkrehi 2284 21 GCS GCS NNP cord-335975-m6lkrehi 2284 22 < < XX cord-335975-m6lkrehi 2284 23 15 15 CD cord-335975-m6lkrehi 2284 24 , , , cord-335975-m6lkrehi 2284 25 Signs sign NNS cord-335975-m6lkrehi 2284 26 of of IN cord-335975-m6lkrehi 2284 27 trauma trauma NN cord-335975-m6lkrehi 2284 28 in in IN cord-335975-m6lkrehi 2284 29 the the DT cord-335975-m6lkrehi 2284 30 skull skull NN cord-335975-m6lkrehi 2284 31 face face NN cord-335975-m6lkrehi 2284 32 , , , cord-335975-m6lkrehi 2284 33 the the DT cord-335975-m6lkrehi 2284 34 vomiting vomiting NN cord-335975-m6lkrehi 2284 35 , , , cord-335975-m6lkrehi 2284 36 the the DT cord-335975-m6lkrehi 2284 37 Initial initial JJ cord-335975-m6lkrehi 2284 38 loss loss NN cord-335975-m6lkrehi 2284 39 of of IN cord-335975-m6lkrehi 2284 40 consciousness consciousness NN cord-335975-m6lkrehi 2284 41 , , , cord-335975-m6lkrehi 2284 42 the the DT cord-335975-m6lkrehi 2284 43 Comitial Comitial NNP cord-335975-m6lkrehi 2284 44 crisis crisis NN cord-335975-m6lkrehi 2284 45 and and CC cord-335975-m6lkrehi 2284 46 the the DT cord-335975-m6lkrehi 2284 47 predictive predictive JJ cord-335975-m6lkrehi 2284 48 factors factor NNS cord-335975-m6lkrehi 2284 49 of of IN cord-335975-m6lkrehi 2284 50 neurosurgical neurosurgical JJ cord-335975-m6lkrehi 2284 51 care care NN cord-335975-m6lkrehi 2284 52 were be VBD cord-335975-m6lkrehi 2284 53 the the DT cord-335975-m6lkrehi 2284 54 GCS GCS NNP cord-335975-m6lkrehi 2284 55 < < XX cord-335975-m6lkrehi 2284 56 15 15 CD cord-335975-m6lkrehi 2284 57 , , , cord-335975-m6lkrehi 2284 58 the the DT cord-335975-m6lkrehi 2284 59 anisocoria anisocoria NN cord-335975-m6lkrehi 2284 60 , , , cord-335975-m6lkrehi 2284 61 Headache headache NN cord-335975-m6lkrehi 2284 62 , , , cord-335975-m6lkrehi 2284 63 the the DT cord-335975-m6lkrehi 2284 64 vomiting vomiting NN cord-335975-m6lkrehi 2284 65 , , , cord-335975-m6lkrehi 2284 66 the the DT cord-335975-m6lkrehi 2284 67 amnesia amnesia NN cord-335975-m6lkrehi 2284 68 , , , cord-335975-m6lkrehi 2284 69 the the DT cord-335975-m6lkrehi 2284 70 Initial initial JJ cord-335975-m6lkrehi 2284 71 loss loss NN cord-335975-m6lkrehi 2284 72 of of IN cord-335975-m6lkrehi 2284 73 consciousness consciousness NN cord-335975-m6lkrehi 2284 74 , , , cord-335975-m6lkrehi 2284 75 the the DT cord-335975-m6lkrehi 2284 76 Comitial Comitial NNP cord-335975-m6lkrehi 2284 77 crisis crisis NN cord-335975-m6lkrehi 2284 78 , , , cord-335975-m6lkrehi 2284 79 the the DT cord-335975-m6lkrehi 2284 80 anormal anormal JJ cord-335975-m6lkrehi 2284 81 CT CT NNP cord-335975-m6lkrehi 2284 82 , , , cord-335975-m6lkrehi 2284 83 the the DT cord-335975-m6lkrehi 2284 84 Extradural Extradural NNP cord-335975-m6lkrehi 2284 85 hematoma hematoma NN cord-335975-m6lkrehi 2284 86 or or CC cord-335975-m6lkrehi 2284 87 the the DT cord-335975-m6lkrehi 2284 88 Subdural Subdural NNP cord-335975-m6lkrehi 2284 89 hematomat hematomat NN cord-335975-m6lkrehi 2285 1 In in IN cord-335975-m6lkrehi 2285 2 multivariate multivariate JJ cord-335975-m6lkrehi 2285 3 analysis analysis NN cord-335975-m6lkrehi 2285 4 - - , cord-335975-m6lkrehi 2285 5 the the DT cord-335975-m6lkrehi 2285 6 predictive predictive JJ cord-335975-m6lkrehi 2285 7 factors factor NNS cord-335975-m6lkrehi 2285 8 for for IN cord-335975-m6lkrehi 2285 9 a a DT cord-335975-m6lkrehi 2285 10 CT CT NNP cord-335975-m6lkrehi 2285 11 abnormality abnormality NN cord-335975-m6lkrehi 2285 12 were be VBD cord-335975-m6lkrehi 2285 13 the the DT cord-335975-m6lkrehi 2285 14 GCS GCS NNP cord-335975-m6lkrehi 2285 15 < < XX cord-335975-m6lkrehi 2285 16 15 15 CD cord-335975-m6lkrehi 2285 17 , , , cord-335975-m6lkrehi 2285 18 the the DT cord-335975-m6lkrehi 2285 19 Initial initial JJ cord-335975-m6lkrehi 2285 20 loss loss NN cord-335975-m6lkrehi 2285 21 of of IN cord-335975-m6lkrehi 2285 22 consciousness consciousness NN cord-335975-m6lkrehi 2285 23 and and CC cord-335975-m6lkrehi 2285 24 the the DT cord-335975-m6lkrehi 2285 25 predictive predictive JJ cord-335975-m6lkrehi 2285 26 factors factor NNS cord-335975-m6lkrehi 2285 27 for for IN cord-335975-m6lkrehi 2285 28 the the DT cord-335975-m6lkrehi 2285 29 use use NN cord-335975-m6lkrehi 2285 30 of of IN cord-335975-m6lkrehi 2285 31 neurosurgical neurosurgical JJ cord-335975-m6lkrehi 2285 32 care care NN cord-335975-m6lkrehi 2285 33 were be VBD cord-335975-m6lkrehi 2285 34 the the DT cord-335975-m6lkrehi 2285 35 GCS GCS NNP cord-335975-m6lkrehi 2285 36 < < XX cord-335975-m6lkrehi 2285 37 15 15 CD cord-335975-m6lkrehi 2285 38 , , , cord-335975-m6lkrehi 2285 39 Signs sign NNS cord-335975-m6lkrehi 2285 40 of of IN cord-335975-m6lkrehi 2285 41 trauma trauma NN cord-335975-m6lkrehi 2285 42 in in IN cord-335975-m6lkrehi 2285 43 the the DT cord-335975-m6lkrehi 2285 44 skull skull NN cord-335975-m6lkrehi 2285 45 face face NN cord-335975-m6lkrehi 2285 46 , , , cord-335975-m6lkrehi 2285 47 the the DT cord-335975-m6lkrehi 2285 48 amnesia amnesia NN cord-335975-m6lkrehi 2285 49 , , , cord-335975-m6lkrehi 2285 50 the the DT cord-335975-m6lkrehi 2285 51 Comitial Comitial NNP cord-335975-m6lkrehi 2285 52 crisis crisis NN cord-335975-m6lkrehi 2285 53 , , , cord-335975-m6lkrehi 2285 54 the the DT cord-335975-m6lkrehi 2285 55 HSD HSD NNP cord-335975-m6lkrehi 2285 56 . . . cord-335975-m6lkrehi 2286 1 Conclusion conclusion NN cord-335975-m6lkrehi 2286 2 : : : cord-335975-m6lkrehi 2286 3 an an DT cord-335975-m6lkrehi 2286 4 algorithm algorithm NN cord-335975-m6lkrehi 2286 5 must must MD cord-335975-m6lkrehi 2286 6 be be VB cord-335975-m6lkrehi 2286 7 applied apply VBN cord-335975-m6lkrehi 2286 8 in in IN cord-335975-m6lkrehi 2286 9 collaboration collaboration NN cord-335975-m6lkrehi 2286 10 between between IN cord-335975-m6lkrehi 2286 11 resuscitators resuscitator NNS cord-335975-m6lkrehi 2286 12 and and CC cord-335975-m6lkrehi 2286 13 neurosurgeons neurosurgeon NNS cord-335975-m6lkrehi 2286 14 to to TO cord-335975-m6lkrehi 2286 15 improve improve VB cord-335975-m6lkrehi 2286 16 the the DT cord-335975-m6lkrehi 2286 17 quality quality NN cord-335975-m6lkrehi 2286 18 of of IN cord-335975-m6lkrehi 2286 19 benign benign JJ cord-335975-m6lkrehi 2286 20 cranial cranial JJ cord-335975-m6lkrehi 2286 21 trauma trauma NN cord-335975-m6lkrehi 2286 22 management management NN cord-335975-m6lkrehi 2286 23 . . . cord-335975-m6lkrehi 2287 1 Prognostic prognostic JJ cord-335975-m6lkrehi 2287 2 value value NN cord-335975-m6lkrehi 2287 3 of of IN cord-335975-m6lkrehi 2287 4 hyperchloremia hyperchloremia NN cord-335975-m6lkrehi 2287 5 in in IN cord-335975-m6lkrehi 2287 6 patients patient NNS cord-335975-m6lkrehi 2287 7 with with IN cord-335975-m6lkrehi 2287 8 traumatic traumatic JJ cord-335975-m6lkrehi 2287 9 brain brain NN cord-335975-m6lkrehi 2287 10 injury injury NN cord-335975-m6lkrehi 2287 11 : : : cord-335975-m6lkrehi 2287 12 a a DT cord-335975-m6lkrehi 2287 13 prospective prospective JJ cord-335975-m6lkrehi 2287 14 observational observational JJ cord-335975-m6lkrehi 2287 15 study study NN cord-335975-m6lkrehi 2287 16 Taghouti Taghouti NNP cord-335975-m6lkrehi 2287 17 Introduction introduction NN cord-335975-m6lkrehi 2287 18 : : : cord-335975-m6lkrehi 2287 19 Background background NN cord-335975-m6lkrehi 2287 20 - - HYPH cord-335975-m6lkrehi 2287 21 Traumatic traumatic JJ cord-335975-m6lkrehi 2287 22 brain brain NN cord-335975-m6lkrehi 2287 23 injuries injury NNS cord-335975-m6lkrehi 2288 1 ( ( -LRB- cord-335975-m6lkrehi 2288 2 TBI TBI NNP cord-335975-m6lkrehi 2288 3 ) ) -RRB- cord-335975-m6lkrehi 2288 4 are be VBP cord-335975-m6lkrehi 2288 5 a a DT cord-335975-m6lkrehi 2288 6 major major JJ cord-335975-m6lkrehi 2288 7 public public JJ cord-335975-m6lkrehi 2288 8 health health NN cord-335975-m6lkrehi 2288 9 problem problem NN cord-335975-m6lkrehi 2288 10 . . . cord-335975-m6lkrehi 2289 1 They -PRON- PRP cord-335975-m6lkrehi 2289 2 are be VBP cord-335975-m6lkrehi 2289 3 the the DT cord-335975-m6lkrehi 2289 4 leading leading JJ cord-335975-m6lkrehi 2289 5 cause cause NN cord-335975-m6lkrehi 2289 6 of of IN cord-335975-m6lkrehi 2289 7 death death NN cord-335975-m6lkrehi 2289 8 among among IN cord-335975-m6lkrehi 2289 9 those those DT cord-335975-m6lkrehi 2289 10 aged aged JJ cord-335975-m6lkrehi 2289 11 less less JJR cord-335975-m6lkrehi 2289 12 than than IN cord-335975-m6lkrehi 2289 13 40 40 CD cord-335975-m6lkrehi 2289 14 years year NNS cord-335975-m6lkrehi 2289 15 . . . cord-335975-m6lkrehi 2290 1 Hyperchloremia Hyperchloremia NNP cord-335975-m6lkrehi 2290 2 is be VBZ cord-335975-m6lkrehi 2290 3 a a DT cord-335975-m6lkrehi 2290 4 common common JJ cord-335975-m6lkrehi 2290 5 electrolyte electrolyte JJ cord-335975-m6lkrehi 2290 6 disturbance disturbance NN cord-335975-m6lkrehi 2290 7 in in IN cord-335975-m6lkrehi 2290 8 patients patient NNS cord-335975-m6lkrehi 2290 9 with with IN cord-335975-m6lkrehi 2290 10 TBI TBI NNP cord-335975-m6lkrehi 2290 11 . . . cord-335975-m6lkrehi 2291 1 Hyperchloremia Hyperchloremia NNP cord-335975-m6lkrehi 2291 2 has have VBZ cord-335975-m6lkrehi 2291 3 been be VBN cord-335975-m6lkrehi 2291 4 associated associate VBN cord-335975-m6lkrehi 2291 5 with with IN cord-335975-m6lkrehi 2291 6 increased increase VBN cord-335975-m6lkrehi 2291 7 morbidity morbidity NN cord-335975-m6lkrehi 2291 8 and and CC cord-335975-m6lkrehi 2291 9 mortality mortality NN cord-335975-m6lkrehi 2291 10 in in IN cord-335975-m6lkrehi 2291 11 critically critically RB cord-335975-m6lkrehi 2291 12 ill ill JJ cord-335975-m6lkrehi 2291 13 patients patient NNS cord-335975-m6lkrehi 2291 14 + + CC cord-335975-m6lkrehi 2291 15 however however RB cord-335975-m6lkrehi 2291 16 , , , cord-335975-m6lkrehi 2291 17 its -PRON- PRP$ cord-335975-m6lkrehi 2291 18 prognostic prognostic JJ cord-335975-m6lkrehi 2291 19 significance significance NN cord-335975-m6lkrehi 2291 20 in in IN cord-335975-m6lkrehi 2291 21 TBI TBI NNP cord-335975-m6lkrehi 2291 22 patients patient NNS cord-335975-m6lkrehi 2291 23 is be VBZ cord-335975-m6lkrehi 2291 24 poorly poorly RB cord-335975-m6lkrehi 2291 25 documented document VBN cord-335975-m6lkrehi 2291 26 . . . cord-335975-m6lkrehi 2292 1 The the DT cord-335975-m6lkrehi 2292 2 aim aim NN cord-335975-m6lkrehi 2292 3 of of IN cord-335975-m6lkrehi 2292 4 this this DT cord-335975-m6lkrehi 2292 5 study study NN cord-335975-m6lkrehi 2292 6 is be VBZ cord-335975-m6lkrehi 2292 7 to to TO cord-335975-m6lkrehi 2292 8 describe describe VB cord-335975-m6lkrehi 2292 9 the the DT cord-335975-m6lkrehi 2292 10 prevalence prevalence NN cord-335975-m6lkrehi 2292 11 and and CC cord-335975-m6lkrehi 2292 12 outcomes outcome NNS cord-335975-m6lkrehi 2292 13 of of IN cord-335975-m6lkrehi 2292 14 hyperchloremia hyperchloremia NN cord-335975-m6lkrehi 2292 15 in in IN cord-335975-m6lkrehi 2292 16 patients patient NNS cord-335975-m6lkrehi 2292 17 with with IN cord-335975-m6lkrehi 2292 18 TBI TBI NNP cord-335975-m6lkrehi 2292 19 admitted admit VBD cord-335975-m6lkrehi 2292 20 to to IN cord-335975-m6lkrehi 2292 21 the the DT cord-335975-m6lkrehi 2292 22 intensive intensive JJ cord-335975-m6lkrehi 2292 23 care care NN cord-335975-m6lkrehi 2292 24 unit unit NN cord-335975-m6lkrehi 2292 25 . . . cord-335975-m6lkrehi 2293 1 Patients patient NNS cord-335975-m6lkrehi 2293 2 and and CC cord-335975-m6lkrehi 2293 3 methods method NNS cord-335975-m6lkrehi 2294 1 : : : cord-335975-m6lkrehi 2294 2 In in IN cord-335975-m6lkrehi 2294 3 a a DT cord-335975-m6lkrehi 2294 4 prospective prospective JJ cord-335975-m6lkrehi 2294 5 design design NN cord-335975-m6lkrehi 2294 6 , , , cord-335975-m6lkrehi 2294 7 we -PRON- PRP cord-335975-m6lkrehi 2294 8 included include VBD cord-335975-m6lkrehi 2294 9 43 43 CD cord-335975-m6lkrehi 2294 10 consecutive consecutive JJ cord-335975-m6lkrehi 2294 11 patients patient NNS cord-335975-m6lkrehi 2294 12 with with IN cord-335975-m6lkrehi 2294 13 TBI TBI NNP cord-335975-m6lkrehi 2294 14 ( ( -LRB- cord-335975-m6lkrehi 2294 15 37 37 CD cord-335975-m6lkrehi 2294 16 males male NNS cord-335975-m6lkrehi 2294 17 + + CC cord-335975-m6lkrehi 2294 18 median median JJ cord-335975-m6lkrehi 2294 19 age-52 age-52 NNP cord-335975-m6lkrehi 2294 20 years year NNS cord-335975-m6lkrehi 2294 21 ) ) -RRB- cord-335975-m6lkrehi 2294 22 admitted admit VBD cord-335975-m6lkrehi 2294 23 to to IN cord-335975-m6lkrehi 2294 24 the the DT cord-335975-m6lkrehi 2294 25 ICU ICU NNP cord-335975-m6lkrehi 2294 26 in in IN cord-335975-m6lkrehi 2294 27 Charles Charles NNP cord-335975-m6lkrehi 2294 28 Nicolle Nicolle NNP cord-335975-m6lkrehi 2294 29 Hospital Hospital NNP cord-335975-m6lkrehi 2294 30 of of IN cord-335975-m6lkrehi 2294 31 Tunis Tunis NNP cord-335975-m6lkrehi 2294 32 from from IN cord-335975-m6lkrehi 2294 33 Mars Mars NNP cord-335975-m6lkrehi 2294 34 to to IN cord-335975-m6lkrehi 2294 35 September September NNP cord-335975-m6lkrehi 2294 36 2017 2017 CD cord-335975-m6lkrehi 2294 37 . . . cord-335975-m6lkrehi 2295 1 Adult adult NN cord-335975-m6lkrehi 2295 2 patients patient NNS cord-335975-m6lkrehi 2295 3 ( ( -LRB- cord-335975-m6lkrehi 2295 4 aged aged JJ cord-335975-m6lkrehi 2295 5 ≥ ≥ CD cord-335975-m6lkrehi 2295 6 18 18 CD cord-335975-m6lkrehi 2295 7 years year NNS cord-335975-m6lkrehi 2295 8 ) ) -RRB- cord-335975-m6lkrehi 2295 9 with with IN cord-335975-m6lkrehi 2295 10 isolated isolate VBN cord-335975-m6lkrehi 2295 11 TBI TBI NNP cord-335975-m6lkrehi 2295 12 or or CC cord-335975-m6lkrehi 2295 13 associated associate VBN cord-335975-m6lkrehi 2295 14 with with IN cord-335975-m6lkrehi 2295 15 minor minor JJ cord-335975-m6lkrehi 2295 16 extra extra JJ cord-335975-m6lkrehi 2295 17 - - JJ cord-335975-m6lkrehi 2295 18 cranial cranial JJ cord-335975-m6lkrehi 2295 19 injuries injury NNS cord-335975-m6lkrehi 2295 20 ( ( -LRB- cord-335975-m6lkrehi 2295 21 defined define VBN cord-335975-m6lkrehi 2295 22 as as IN cord-335975-m6lkrehi 2295 23 all all DT cord-335975-m6lkrehi 2295 24 non non JJ cord-335975-m6lkrehi 2295 25 - - JJ cord-335975-m6lkrehi 2295 26 head head JJ cord-335975-m6lkrehi 2295 27 Abbreviated Abbreviated NNP cord-335975-m6lkrehi 2295 28 Injury injury NN cord-335975-m6lkrehi 2295 29 Scale Scale NNP cord-335975-m6lkrehi 2295 30 < < XX cord-335975-m6lkrehi 2295 31 3 3 CD cord-335975-m6lkrehi 2295 32 ) ) -RRB- cord-335975-m6lkrehi 2295 33 were be VBD cord-335975-m6lkrehi 2295 34 included include VBN cord-335975-m6lkrehi 2295 35 . . . cord-335975-m6lkrehi 2296 1 Hyperchloremia Hyperchloremia NNP cord-335975-m6lkrehi 2296 2 was be VBD cord-335975-m6lkrehi 2296 3 defined define VBN cord-335975-m6lkrehi 2296 4 as as IN cord-335975-m6lkrehi 2296 5 a a DT cord-335975-m6lkrehi 2296 6 chloride chloride NN cord-335975-m6lkrehi 2296 7 level level NN cord-335975-m6lkrehi 2296 8 > > XX cord-335975-m6lkrehi 2297 1 110mEg 110mEg NNP cord-335975-m6lkrehi 2297 2 / / SYM cord-335975-m6lkrehi 2297 3 l l NN cord-335975-m6lkrehi 2297 4 . . . cord-335975-m6lkrehi 2298 1 Clinical clinical JJ cord-335975-m6lkrehi 2298 2 and and CC cord-335975-m6lkrehi 2298 3 laboratory laboratory NN cord-335975-m6lkrehi 2298 4 variables variable NNS cord-335975-m6lkrehi 2298 5 were be VBD cord-335975-m6lkrehi 2298 6 compared compare VBN cord-335975-m6lkrehi 2298 7 between between IN cord-335975-m6lkrehi 2298 8 survivors survivor NNS cord-335975-m6lkrehi 2298 9 ( ( -LRB- cord-335975-m6lkrehi 2298 10 n n NN cord-335975-m6lkrehi 2298 11 = = SYM cord-335975-m6lkrehi 2298 12 36 36 CD cord-335975-m6lkrehi 2298 13 ) ) -RRB- cord-335975-m6lkrehi 2298 14 and and CC cord-335975-m6lkrehi 2298 15 non non NNS cord-335975-m6lkrehi 2298 16 - - NNS cord-335975-m6lkrehi 2298 17 survivors survivor NNS cord-335975-m6lkrehi 2298 18 ( ( -LRB- cord-335975-m6lkrehi 2298 19 n n NN cord-335975-m6lkrehi 2298 20 = = SYM cord-335975-m6lkrehi 2298 21 7 7 CD cord-335975-m6lkrehi 2298 22 ) ) -RRB- cord-335975-m6lkrehi 2298 23 . . . cord-335975-m6lkrehi 2299 1 We -PRON- PRP cord-335975-m6lkrehi 2299 2 assessed assess VBD cord-335975-m6lkrehi 2299 3 the the DT cord-335975-m6lkrehi 2299 4 association association NN cord-335975-m6lkrehi 2299 5 between between IN cord-335975-m6lkrehi 2299 6 hyperchloremia hyperchloremia NNP cord-335975-m6lkrehi 2299 7 24-h 24-h NNP cord-335975-m6lkrehi 2299 8 post post JJ cord-335975-m6lkrehi 2299 9 - - JJ cord-335975-m6lkrehi 2299 10 admission admission JJ cord-335975-m6lkrehi 2299 11 and and CC cord-335975-m6lkrehi 2299 12 30-day 30-day CD cord-335975-m6lkrehi 2299 13 mortality mortality NN cord-335975-m6lkrehi 2299 14 . . . cord-335975-m6lkrehi 2300 1 p p NN cord-335975-m6lkrehi 2300 2 < < XX cord-335975-m6lkrehi 2300 3 0.05 0.05 CD cord-335975-m6lkrehi 2300 4 was be VBD cord-335975-m6lkrehi 2300 5 taken take VBN cord-335975-m6lkrehi 2300 6 to to TO cord-335975-m6lkrehi 2300 7 indicate indicate VB cord-335975-m6lkrehi 2300 8 statistical statistical JJ cord-335975-m6lkrehi 2300 9 significance significance NN cord-335975-m6lkrehi 2300 10 . . . cord-335975-m6lkrehi 2301 1 Results result NNS cord-335975-m6lkrehi 2301 2 : : : cord-335975-m6lkrehi 2302 1 The the DT cord-335975-m6lkrehi 2302 2 median median JJ cord-335975-m6lkrehi 2302 3 SOFA sofa NN cord-335975-m6lkrehi 2302 4 score score NN cord-335975-m6lkrehi 2302 5 at at IN cord-335975-m6lkrehi 2302 6 T0 T0 NNP cord-335975-m6lkrehi 2302 7 was be VBD cord-335975-m6lkrehi 2302 8 7 7 CD cord-335975-m6lkrehi 2302 9 points point NNS cord-335975-m6lkrehi 2302 10 and and CC cord-335975-m6lkrehi 2302 11 the the DT cord-335975-m6lkrehi 2302 12 median median JJ cord-335975-m6lkrehi 2302 13 IGS IGS NNP cord-335975-m6lkrehi 2302 14 2 2 CD cord-335975-m6lkrehi 2302 15 score score NN cord-335975-m6lkrehi 2302 16 was be VBD cord-335975-m6lkrehi 2302 17 32 32 CD cord-335975-m6lkrehi 2302 18 points point NNS cord-335975-m6lkrehi 2302 19 . . . cord-335975-m6lkrehi 2303 1 The the DT cord-335975-m6lkrehi 2303 2 median median NN cord-335975-m6lkrehi 2303 3 ISS ISS NNP cord-335975-m6lkrehi 2303 4 was be VBD cord-335975-m6lkrehi 2303 5 25 25 CD cord-335975-m6lkrehi 2303 6 points point NNS cord-335975-m6lkrehi 2303 7 . . . cord-335975-m6lkrehi 2304 1 There there EX cord-335975-m6lkrehi 2304 2 were be VBD cord-335975-m6lkrehi 2304 3 11 11 CD cord-335975-m6lkrehi 2304 4 cases case NNS cord-335975-m6lkrehi 2304 5 of of IN cord-335975-m6lkrehi 2304 6 mild mild JJ cord-335975-m6lkrehi 2304 7 head head NN cord-335975-m6lkrehi 2304 8 injury injury NN cord-335975-m6lkrehi 2304 9 , , , cord-335975-m6lkrehi 2304 10 12 12 CD cord-335975-m6lkrehi 2304 11 moderate moderate JJ cord-335975-m6lkrehi 2304 12 head head NN cord-335975-m6lkrehi 2304 13 injury injury NN cord-335975-m6lkrehi 2304 14 and and CC cord-335975-m6lkrehi 2304 15 20 20 CD cord-335975-m6lkrehi 2304 16 severe severe JJ cord-335975-m6lkrehi 2304 17 head head NN cord-335975-m6lkrehi 2304 18 injury injury NN cord-335975-m6lkrehi 2304 19 . . . cord-335975-m6lkrehi 2305 1 The the DT cord-335975-m6lkrehi 2305 2 30-day 30-day CD cord-335975-m6lkrehi 2305 3 mortality mortality NN cord-335975-m6lkrehi 2305 4 was be VBD cord-335975-m6lkrehi 2305 5 16 16 CD cord-335975-m6lkrehi 2305 6 % % NN cord-335975-m6lkrehi 2305 7 . . . cord-335975-m6lkrehi 2306 1 Hyperchloremia Hyperchloremia NNP cord-335975-m6lkrehi 2306 2 occurred occur VBD cord-335975-m6lkrehi 2306 3 in in IN cord-335975-m6lkrehi 2306 4 15 15 CD cord-335975-m6lkrehi 2306 5 patients patient NNS cord-335975-m6lkrehi 2306 6 ( ( -LRB- cord-335975-m6lkrehi 2306 7 35 35 CD cord-335975-m6lkrehi 2306 8 % % NN cord-335975-m6lkrehi 2306 9 ) ) -RRB- cord-335975-m6lkrehi 2306 10 and and CC cord-335975-m6lkrehi 2306 11 the the DT cord-335975-m6lkrehi 2306 12 incidence incidence NN cord-335975-m6lkrehi 2306 13 was be VBD cord-335975-m6lkrehi 2306 14 significantly significantly RB cord-335975-m6lkrehi 2306 15 different different JJ cord-335975-m6lkrehi 2306 16 between between IN cord-335975-m6lkrehi 2306 17 survivors survivor NNS cord-335975-m6lkrehi 2306 18 and and CC cord-335975-m6lkrehi 2306 19 non non NNS cord-335975-m6lkrehi 2306 20 - - NNS cord-335975-m6lkrehi 2306 21 survivors survivor NNS cord-335975-m6lkrehi 2306 22 ( ( -LRB- cord-335975-m6lkrehi 2306 23 28 28 CD cord-335975-m6lkrehi 2306 24 vs. vs. CC cord-335975-m6lkrehi 2306 25 72 72 CD cord-335975-m6lkrehi 2306 26 % % NN cord-335975-m6lkrehi 2306 27 , , , cord-335975-m6lkrehi 2306 28 respectively respectively RB cord-335975-m6lkrehi 2306 29 , , , cord-335975-m6lkrehi 2306 30 p p NN cord-335975-m6lkrehi 2306 31 < < XX cord-335975-m6lkrehi 2306 32 0.001 0.001 CD cord-335975-m6lkrehi 2306 33 ) ) -RRB- cord-335975-m6lkrehi 2306 34 . . . cord-335975-m6lkrehi 2307 1 In in IN cord-335975-m6lkrehi 2307 2 addition addition NN cord-335975-m6lkrehi 2307 3 to to IN cord-335975-m6lkrehi 2307 4 hyperchloremia hyperchloremia NN cord-335975-m6lkrehi 2307 5 ( ( -LRB- cord-335975-m6lkrehi 2307 6 p p NN cord-335975-m6lkrehi 2307 7 = = SYM cord-335975-m6lkrehi 2307 8 0.018 0.018 CD cord-335975-m6lkrehi 2307 9 ) ) -RRB- cord-335975-m6lkrehi 2307 10 , , , cord-335975-m6lkrehi 2307 11 other other JJ cord-335975-m6lkrehi 2307 12 laboratory laboratory NN cord-335975-m6lkrehi 2307 13 variables variable NNS cord-335975-m6lkrehi 2307 14 were be VBD cord-335975-m6lkrehi 2307 15 associated associate VBN cord-335975-m6lkrehi 2307 16 with with IN cord-335975-m6lkrehi 2307 17 30-day 30-day CD cord-335975-m6lkrehi 2307 18 mortality mortality NN cord-335975-m6lkrehi 2307 19 - - HYPH cord-335975-m6lkrehi 2307 20 hypernatremia hypernatremia NN cord-335975-m6lkrehi 2307 21 ( ( -LRB- cord-335975-m6lkrehi 2307 22 p p NN cord-335975-m6lkrehi 2307 23 = = SYM cord-335975-m6lkrehi 2307 24 0.011 0.011 CD cord-335975-m6lkrehi 2307 25 ) ) -RRB- cord-335975-m6lkrehi 2307 26 and and CC cord-335975-m6lkrehi 2307 27 hypoalbuminemia hypoalbuminemia NNP cord-335975-m6lkrehi 2307 28 ( ( -LRB- cord-335975-m6lkrehi 2307 29 p p NN cord-335975-m6lkrehi 2307 30 = = SYM cord-335975-m6lkrehi 2307 31 0.024 0.024 CD cord-335975-m6lkrehi 2307 32 ) ) -RRB- cord-335975-m6lkrehi 2307 33 . . . cord-335975-m6lkrehi 2308 1 Conclusion conclusion NN cord-335975-m6lkrehi 2308 2 : : : cord-335975-m6lkrehi 2308 3 Hyperchloremia Hyperchloremia NNP cord-335975-m6lkrehi 2308 4 24-h 24-h JJ cord-335975-m6lkrehi 2308 5 post post JJ cord-335975-m6lkrehi 2308 6 - - JJ cord-335975-m6lkrehi 2308 7 admission admission NN cord-335975-m6lkrehi 2308 8 was be VBD cord-335975-m6lkrehi 2308 9 associated associate VBN cord-335975-m6lkrehi 2308 10 with with IN cord-335975-m6lkrehi 2308 11 30-day 30-day CD cord-335975-m6lkrehi 2308 12 mortality mortality NN cord-335975-m6lkrehi 2308 13 in in IN cord-335975-m6lkrehi 2308 14 patients patient NNS cord-335975-m6lkrehi 2308 15 with with IN cord-335975-m6lkrehi 2308 16 TBI TBI NNP cord-335975-m6lkrehi 2308 17 . . . cord-335975-m6lkrehi 2309 1 This this DT cord-335975-m6lkrehi 2309 2 index index NN cord-335975-m6lkrehi 2309 3 could could MD cord-335975-m6lkrehi 2309 4 be be VB cord-335975-m6lkrehi 2309 5 useful useful JJ cord-335975-m6lkrehi 2309 6 prognostic prognostic JJ cord-335975-m6lkrehi 2309 7 marker marker NN cord-335975-m6lkrehi 2309 8 . . . cord-335975-m6lkrehi 2310 1 Efforts effort NNS cord-335975-m6lkrehi 2310 2 should should MD cord-335975-m6lkrehi 2310 3 focus focus VB cord-335975-m6lkrehi 2310 4 on on IN cord-335975-m6lkrehi 2310 5 the the DT cord-335975-m6lkrehi 2310 6 prevention prevention NN cord-335975-m6lkrehi 2310 7 of of IN cord-335975-m6lkrehi 2310 8 hypernatremia hypernatremia NN cord-335975-m6lkrehi 2310 9 and and CC cord-335975-m6lkrehi 2310 10 hyperchloremia hyperchloremia NN cord-335975-m6lkrehi 2310 11 in in IN cord-335975-m6lkrehi 2310 12 this this DT cord-335975-m6lkrehi 2310 13 vulnerable vulnerable JJ cord-335975-m6lkrehi 2310 14 group group NN cord-335975-m6lkrehi 2310 15 of of IN cord-335975-m6lkrehi 2310 16 critically critically RB cord-335975-m6lkrehi 2310 17 ill ill JJ cord-335975-m6lkrehi 2310 18 patients patient NNS cord-335975-m6lkrehi 2310 19 . . . cord-335975-m6lkrehi 2311 1 Child child NN cord-335975-m6lkrehi 2311 2 traumatic traumatic JJ cord-335975-m6lkrehi 2311 3 brain brain NN cord-335975-m6lkrehi 2311 4 injury injury NN cord-335975-m6lkrehi 2311 5 Naili Naili NNP cord-335975-m6lkrehi 2311 6 Amine Amine NNP cord-335975-m6lkrehi 2311 7 1 1 CD cord-335975-m6lkrehi 2311 8 1 1 CD cord-335975-m6lkrehi 2312 1 Blida Blida NNP cord-335975-m6lkrehi 2312 2 Rp Rp NNP cord-335975-m6lkrehi 2312 3 , , , cord-335975-m6lkrehi 2312 4 ALGÉRIE ALGÉRIE NNP cord-335975-m6lkrehi 2312 5 Correspondence correspondence NN cord-335975-m6lkrehi 2312 6 : : : cord-335975-m6lkrehi 2313 1 Naili Naili NNP cord-335975-m6lkrehi 2313 2 Amine Amine NNP cord-335975-m6lkrehi 2313 3 -drnailiamine@yahoo.fr -drnailiamine@yahoo.fr NNP cord-335975-m6lkrehi 2313 4 Annals Annals NNP cord-335975-m6lkrehi 2313 5 of of IN cord-335975-m6lkrehi 2313 6 Intensive Intensive NNP cord-335975-m6lkrehi 2313 7 Care Care NNP cord-335975-m6lkrehi 2313 8 2018 2018 CD cord-335975-m6lkrehi 2313 9 , , , cord-335975-m6lkrehi 2313 10 8(Suppl 8(suppl CD cord-335975-m6lkrehi 2313 11 1):P-07 1):p-07 CD cord-335975-m6lkrehi 2314 1 Introduction introduction NN cord-335975-m6lkrehi 2314 2 : : : cord-335975-m6lkrehi 2314 3 Brain brain NN cord-335975-m6lkrehi 2314 4 injury injury NN cord-335975-m6lkrehi 2314 5 in in IN cord-335975-m6lkrehi 2314 6 children child NNS cord-335975-m6lkrehi 2314 7 is be VBZ cord-335975-m6lkrehi 2314 8 common common JJ cord-335975-m6lkrehi 2314 9 and and CC cord-335975-m6lkrehi 2314 10 mild mild JJ cord-335975-m6lkrehi 2314 11 in in IN cord-335975-m6lkrehi 2314 12 most most JJS cord-335975-m6lkrehi 2314 13 cases case NNS cord-335975-m6lkrehi 2314 14 , , , cord-335975-m6lkrehi 2314 15 but but CC cord-335975-m6lkrehi 2314 16 it -PRON- PRP cord-335975-m6lkrehi 2314 17 remains remain VBZ cord-335975-m6lkrehi 2314 18 the the DT cord-335975-m6lkrehi 2314 19 leading leading JJ cord-335975-m6lkrehi 2314 20 cause cause NN cord-335975-m6lkrehi 2314 21 of of IN cord-335975-m6lkrehi 2314 22 death death NN cord-335975-m6lkrehi 2314 23 and and CC cord-335975-m6lkrehi 2314 24 disability disability NN cord-335975-m6lkrehi 2314 25 in in IN cord-335975-m6lkrehi 2314 26 children child NNS cord-335975-m6lkrehi 2314 27 over over IN cord-335975-m6lkrehi 2314 28 1 1 CD cord-335975-m6lkrehi 2314 29 year year NN cord-335975-m6lkrehi 2314 30 of of IN cord-335975-m6lkrehi 2314 31 age age NN cord-335975-m6lkrehi 2314 32 worldwide worldwide RB cord-335975-m6lkrehi 2314 33 . . . cord-335975-m6lkrehi 2315 1 The the DT cord-335975-m6lkrehi 2315 2 peculiarity peculiarity NN cord-335975-m6lkrehi 2315 3 of of IN cord-335975-m6lkrehi 2315 4 the the DT cord-335975-m6lkrehi 2315 5 child child NN cord-335975-m6lkrehi 2315 6 is be VBZ cord-335975-m6lkrehi 2315 7 that that IN cord-335975-m6lkrehi 2315 8 he -PRON- PRP cord-335975-m6lkrehi 2315 9 possesses possess VBZ cord-335975-m6lkrehi 2315 10 not not RB cord-335975-m6lkrehi 2315 11 mature mature VB cord-335975-m6lkrehi 2315 12 brain brain NN cord-335975-m6lkrehi 2315 13 and and CC cord-335975-m6lkrehi 2315 14 that that IN cord-335975-m6lkrehi 2315 15 the the DT cord-335975-m6lkrehi 2315 16 consequences consequence NNS cord-335975-m6lkrehi 2315 17 of of IN cord-335975-m6lkrehi 2315 18 injuries injury NNS cord-335975-m6lkrehi 2315 19 acquired acquire VBN cord-335975-m6lkrehi 2315 20 by by IN cord-335975-m6lkrehi 2315 21 traumatic traumatic JJ cord-335975-m6lkrehi 2315 22 brain brain NN cord-335975-m6lkrehi 2315 23 injury injury NN cord-335975-m6lkrehi 2315 24 can can MD cord-335975-m6lkrehi 2315 25 lead lead VB cord-335975-m6lkrehi 2315 26 to to IN cord-335975-m6lkrehi 2315 27 the the DT cord-335975-m6lkrehi 2315 28 loss loss NN cord-335975-m6lkrehi 2315 29 of of IN cord-335975-m6lkrehi 2315 30 capacities capacity NNS cord-335975-m6lkrehi 2315 31 , , , cord-335975-m6lkrehi 2315 32 as as RB cord-335975-m6lkrehi 2315 33 well well RB cord-335975-m6lkrehi 2315 34 as as IN cord-335975-m6lkrehi 2315 35 the the DT cord-335975-m6lkrehi 2315 36 non non JJ cord-335975-m6lkrehi 2315 37 - - JJ cord-335975-m6lkrehi 2315 38 acquisition acquisition NN cord-335975-m6lkrehi 2315 39 of of IN cord-335975-m6lkrehi 2315 40 function function NN cord-335975-m6lkrehi 2315 41 , , , cord-335975-m6lkrehi 2315 42 but but CC cord-335975-m6lkrehi 2315 43 above above IN cord-335975-m6lkrehi 2315 44 all all PDT cord-335975-m6lkrehi 2315 45 the the DT cord-335975-m6lkrehi 2315 46 risk risk NN cord-335975-m6lkrehi 2315 47 impact impact NN cord-335975-m6lkrehi 2315 48 on on IN cord-335975-m6lkrehi 2315 49 learning learn VBG cord-335975-m6lkrehi 2315 50 abilities ability NNS cord-335975-m6lkrehi 2315 51 . . . cord-335975-m6lkrehi 2316 1 The the DT cord-335975-m6lkrehi 2316 2 objective objective NN cord-335975-m6lkrehi 2316 3 of of IN cord-335975-m6lkrehi 2316 4 the the DT cord-335975-m6lkrehi 2316 5 study study NN cord-335975-m6lkrehi 2316 6 is be VBZ cord-335975-m6lkrehi 2316 7 to to TO cord-335975-m6lkrehi 2316 8 define define VB cord-335975-m6lkrehi 2316 9 the the DT cord-335975-m6lkrehi 2316 10 incidence incidence NN cord-335975-m6lkrehi 2316 11 rate rate NN cord-335975-m6lkrehi 2316 12 of of IN cord-335975-m6lkrehi 2316 13 cranial cranial JJ cord-335975-m6lkrehi 2316 14 trauma trauma NN cord-335975-m6lkrehi 2316 15 in in IN cord-335975-m6lkrehi 2316 16 children child NNS cord-335975-m6lkrehi 2316 17 as as RB cord-335975-m6lkrehi 2316 18 well well RB cord-335975-m6lkrehi 2316 19 as as IN cord-335975-m6lkrehi 2316 20 the the DT cord-335975-m6lkrehi 2316 21 mortality mortality NN cord-335975-m6lkrehi 2316 22 and and CC cord-335975-m6lkrehi 2316 23 morbidity morbidity NN cord-335975-m6lkrehi 2316 24 of of IN cord-335975-m6lkrehi 2316 25 this this DT cord-335975-m6lkrehi 2316 26 scourge scourge NN cord-335975-m6lkrehi 2316 27 which which WDT cord-335975-m6lkrehi 2316 28 presents present VBZ cord-335975-m6lkrehi 2316 29 a a DT cord-335975-m6lkrehi 2316 30 major major JJ cord-335975-m6lkrehi 2316 31 public public JJ cord-335975-m6lkrehi 2316 32 health health NN cord-335975-m6lkrehi 2316 33 problem problem NN cord-335975-m6lkrehi 2316 34 . . . cord-335975-m6lkrehi 2317 1 Patients patient NNS cord-335975-m6lkrehi 2317 2 and and CC cord-335975-m6lkrehi 2317 3 methods method NNS cord-335975-m6lkrehi 2318 1 : : : cord-335975-m6lkrehi 2318 2 It -PRON- PRP cord-335975-m6lkrehi 2318 3 is be VBZ cord-335975-m6lkrehi 2318 4 a a DT cord-335975-m6lkrehi 2318 5 descriptive descriptive JJ cord-335975-m6lkrehi 2318 6 retrospective retrospective JJ cord-335975-m6lkrehi 2318 7 study study NN cord-335975-m6lkrehi 2318 8 of of IN cord-335975-m6lkrehi 2318 9 a a DT cord-335975-m6lkrehi 2318 10 series series NN cord-335975-m6lkrehi 2318 11 of of IN cord-335975-m6lkrehi 2318 12 186 186 CD cord-335975-m6lkrehi 2318 13 children child NNS cord-335975-m6lkrehi 2318 14 hospitalized hospitalize VBN cord-335975-m6lkrehi 2318 15 in in IN cord-335975-m6lkrehi 2318 16 neuro neuro NNP cord-335975-m6lkrehi 2318 17 - - HYPH cord-335975-m6lkrehi 2318 18 resuscitation resuscitation NNP cord-335975-m6lkrehi 2318 19 service service NN cord-335975-m6lkrehi 2318 20 during during IN cord-335975-m6lkrehi 2318 21 the the DT cord-335975-m6lkrehi 2318 22 period period NN cord-335975-m6lkrehi 2318 23 January January NNP cord-335975-m6lkrehi 2318 24 01 01 CD cord-335975-m6lkrehi 2318 25 to to IN cord-335975-m6lkrehi 2318 26 December December NNP cord-335975-m6lkrehi 2318 27 31 31 CD cord-335975-m6lkrehi 2318 28 , , , cord-335975-m6lkrehi 2318 29 2016 2016 CD cord-335975-m6lkrehi 2318 30 , , , cord-335975-m6lkrehi 2318 31 including include VBG cord-335975-m6lkrehi 2318 32 22 22 CD cord-335975-m6lkrehi 2318 33 children child NNS cord-335975-m6lkrehi 2318 34 admitted admit VBN cord-335975-m6lkrehi 2318 35 for for IN cord-335975-m6lkrehi 2318 36 cranial cranial JJ cord-335975-m6lkrehi 2318 37 trauma trauma NN cord-335975-m6lkrehi 2318 38 . . . cord-335975-m6lkrehi 2319 1 Clinical clinical JJ cord-335975-m6lkrehi 2319 2 , , , cord-335975-m6lkrehi 2319 3 para para NN cord-335975-m6lkrehi 2319 4 - - HYPH cord-335975-m6lkrehi 2319 5 clinical clinical JJ cord-335975-m6lkrehi 2319 6 , , , cord-335975-m6lkrehi 2319 7 etiological etiological JJ cord-335975-m6lkrehi 2319 8 and and CC cord-335975-m6lkrehi 2319 9 therapeutic therapeutic JJ cord-335975-m6lkrehi 2319 10 data datum NNS cord-335975-m6lkrehi 2319 11 were be VBD cord-335975-m6lkrehi 2319 12 collected collect VBN cord-335975-m6lkrehi 2319 13 from from IN cord-335975-m6lkrehi 2319 14 hospitalization hospitalization NN cord-335975-m6lkrehi 2319 15 records record NNS cord-335975-m6lkrehi 2319 16 . . . cord-335975-m6lkrehi 2320 1 Results result NNS cord-335975-m6lkrehi 2320 2 : : : cord-335975-m6lkrehi 2321 1 In in IN cord-335975-m6lkrehi 2321 2 a a DT cord-335975-m6lkrehi 2321 3 series series NN cord-335975-m6lkrehi 2321 4 of of IN cord-335975-m6lkrehi 2321 5 186 186 CD cord-335975-m6lkrehi 2321 6 children child NNS cord-335975-m6lkrehi 2321 7 hospitalized hospitalize VBN cord-335975-m6lkrehi 2321 8 during during IN cord-335975-m6lkrehi 2321 9 the the DT cord-335975-m6lkrehi 2321 10 defined define VBN cord-335975-m6lkrehi 2321 11 period period NN cord-335975-m6lkrehi 2321 12 , , , cord-335975-m6lkrehi 2321 13 22 22 CD cord-335975-m6lkrehi 2321 14 children child NNS cord-335975-m6lkrehi 2321 15 were be VBD cord-335975-m6lkrehi 2321 16 admitted admit VBN cord-335975-m6lkrehi 2321 17 for for IN cord-335975-m6lkrehi 2321 18 cranial cranial JJ cord-335975-m6lkrehi 2321 19 trauma trauma NN cord-335975-m6lkrehi 2321 20 , , , cord-335975-m6lkrehi 2321 21 i.e. i.e. FW cord-335975-m6lkrehi 2321 22 a a DT cord-335975-m6lkrehi 2321 23 frequency frequency NN cord-335975-m6lkrehi 2321 24 of of IN cord-335975-m6lkrehi 2321 25 12 12 CD cord-335975-m6lkrehi 2321 26 % % NN cord-335975-m6lkrehi 2321 27 . . . cord-335975-m6lkrehi 2322 1 The the DT cord-335975-m6lkrehi 2322 2 average average JJ cord-335975-m6lkrehi 2322 3 age age NN cord-335975-m6lkrehi 2322 4 was be VBD cord-335975-m6lkrehi 2322 5 6 6 CD cord-335975-m6lkrehi 2322 6 years year NNS cord-335975-m6lkrehi 2322 7 [ [ -LRB- cord-335975-m6lkrehi 2322 8 6 6 CD cord-335975-m6lkrehi 2322 9 h h NN cord-335975-m6lkrehi 2322 10 of of IN cord-335975-m6lkrehi 2322 11 life-14 life-14 CD cord-335975-m6lkrehi 2322 12 years year NNS cord-335975-m6lkrehi 2322 13 ] ] -RRB- cord-335975-m6lkrehi 2322 14 , , , cord-335975-m6lkrehi 2322 15 with with IN cord-335975-m6lkrehi 2322 16 a a DT cord-335975-m6lkrehi 2322 17 sex sex NN cord-335975-m6lkrehi 2322 18 ration ration NN cord-335975-m6lkrehi 2322 19 of of IN cord-335975-m6lkrehi 2322 20 1 1 CD cord-335975-m6lkrehi 2322 21 Among among IN cord-335975-m6lkrehi 2322 22 the the DT cord-335975-m6lkrehi 2322 23 22 22 CD cord-335975-m6lkrehi 2322 24 children child NNS cord-335975-m6lkrehi 2322 25 , , , cord-335975-m6lkrehi 2322 26 12 12 CD cord-335975-m6lkrehi 2322 27 had have VBD cord-335975-m6lkrehi 2322 28 severe severe JJ cord-335975-m6lkrehi 2322 29 head head NN cord-335975-m6lkrehi 2322 30 trauma trauma NN cord-335975-m6lkrehi 2322 31 , , , cord-335975-m6lkrehi 2322 32 a a DT cord-335975-m6lkrehi 2322 33 rate rate NN cord-335975-m6lkrehi 2322 34 of of IN cord-335975-m6lkrehi 2322 35 55 55 CD cord-335975-m6lkrehi 2322 36 % % NN cord-335975-m6lkrehi 2322 37 + + CC cord-335975-m6lkrehi 2322 38 whose whose WP$ cord-335975-m6lkrehi 2322 39 causes cause NNS cord-335975-m6lkrehi 2322 40 are be VBP cord-335975-m6lkrehi 2322 41 variable-6 variable-6 NN cord-335975-m6lkrehi 2322 42 road road NN cord-335975-m6lkrehi 2322 43 accidents accident NNS cord-335975-m6lkrehi 2322 44 , , , cord-335975-m6lkrehi 2322 45 3 3 CD cord-335975-m6lkrehi 2322 46 domestic domestic JJ cord-335975-m6lkrehi 2322 47 accidents accident NNS cord-335975-m6lkrehi 2322 48 , , , cord-335975-m6lkrehi 2322 49 2 2 CD cord-335975-m6lkrehi 2322 50 traffic traffic NN cord-335975-m6lkrehi 2322 51 accidents accident NNS cord-335975-m6lkrehi 2322 52 , , , cord-335975-m6lkrehi 2322 53 and and CC cord-335975-m6lkrehi 2322 54 1 1 CD cord-335975-m6lkrehi 2322 55 obstetric obstetric JJ cord-335975-m6lkrehi 2322 56 accident accident NN cord-335975-m6lkrehi 2322 57 , , , cord-335975-m6lkrehi 2322 58 admitted admit VBN cord-335975-m6lkrehi 2322 59 with with IN cord-335975-m6lkrehi 2322 60 a a DT cord-335975-m6lkrehi 2322 61 pediatric pediatric JJ cord-335975-m6lkrehi 2322 62 Glasgow Glasgow NNP cord-335975-m6lkrehi 2322 63 score score NN cord-335975-m6lkrehi 2322 64 between between IN cord-335975-m6lkrehi 2322 65 5 5 CD cord-335975-m6lkrehi 2322 66 and and CC cord-335975-m6lkrehi 2322 67 10 10 CD cord-335975-m6lkrehi 2322 68 , , , cord-335975-m6lkrehi 2322 69 and and CC cord-335975-m6lkrehi 2322 70 all all DT cord-335975-m6lkrehi 2322 71 required require VBN cord-335975-m6lkrehi 2322 72 mechanical mechanical JJ cord-335975-m6lkrehi 2322 73 ventilation ventilation NN cord-335975-m6lkrehi 2322 74 of of IN cord-335975-m6lkrehi 2322 75 the the DT cord-335975-m6lkrehi 2322 76 22 22 CD cord-335975-m6lkrehi 2322 77 head head NN cord-335975-m6lkrehi 2322 78 trauma trauma NN cord-335975-m6lkrehi 2322 79 , , , cord-335975-m6lkrehi 2322 80 10 10 CD cord-335975-m6lkrehi 2322 81 were be VBD cord-335975-m6lkrehi 2322 82 operated operate VBN cord-335975-m6lkrehi 2322 83 for for IN cord-335975-m6lkrehi 2322 84 different different JJ cord-335975-m6lkrehi 2322 85 lesions-3 lesions-3 NNP cord-335975-m6lkrehi 2322 86 extra extra JJ cord-335975-m6lkrehi 2322 87 - - HYPH cord-335975-m6lkrehi 2322 88 dural dural JJ cord-335975-m6lkrehi 2322 89 hematomas hematoma NNS cord-335975-m6lkrehi 2322 90 , , , cord-335975-m6lkrehi 2322 91 3 3 CD cord-335975-m6lkrehi 2322 92 cranio cranio JJ cord-335975-m6lkrehi 2322 93 - - HYPH cord-335975-m6lkrehi 2322 94 cerebral cerebral JJ cord-335975-m6lkrehi 2322 95 wounds wound NNS cord-335975-m6lkrehi 2322 96 , , , cord-335975-m6lkrehi 2322 97 2 2 CD cord-335975-m6lkrehi 2322 98 subdural subdural JJ cord-335975-m6lkrehi 2322 99 hematomas hematoma NNS cord-335975-m6lkrehi 2322 100 , , , cord-335975-m6lkrehi 2322 101 1 1 CD cord-335975-m6lkrehi 2322 102 decompressive decompressive NNP cord-335975-m6lkrehi 2322 103 craniectomy craniectomy NN cord-335975-m6lkrehi 2322 104 , , , cord-335975-m6lkrehi 2322 105 and and CC cord-335975-m6lkrehi 2322 106 1 1 CD cord-335975-m6lkrehi 2322 107 embarrure embarrure NN cord-335975-m6lkrehi 2322 108 . . . cord-335975-m6lkrehi 2323 1 02 02 CD cord-335975-m6lkrehi 2323 2 children child NNS cord-335975-m6lkrehi 2323 3 had have VBD cord-335975-m6lkrehi 2323 4 died die VBN cord-335975-m6lkrehi 2323 5 following follow VBG cord-335975-m6lkrehi 2323 6 severe severe JJ cord-335975-m6lkrehi 2323 7 head head NN cord-335975-m6lkrehi 2323 8 trauma trauma NN cord-335975-m6lkrehi 2323 9 , , , cord-335975-m6lkrehi 2323 10 i.e. i.e. FW cord-335975-m6lkrehi 2323 11 a a DT cord-335975-m6lkrehi 2323 12 mortality mortality NN cord-335975-m6lkrehi 2323 13 rate rate NN cord-335975-m6lkrehi 2323 14 of of IN cord-335975-m6lkrehi 2323 15 9 9 CD cord-335975-m6lkrehi 2323 16 % % NN cord-335975-m6lkrehi 2323 17 , , , cord-335975-m6lkrehi 2323 18 the the DT cord-335975-m6lkrehi 2323 19 morbidity morbidity NN cord-335975-m6lkrehi 2323 20 rate rate NN cord-335975-m6lkrehi 2323 21 of of IN cord-335975-m6lkrehi 2323 22 head head NN cord-335975-m6lkrehi 2323 23 trauma trauma NN cord-335975-m6lkrehi 2323 24 in in IN cord-335975-m6lkrehi 2323 25 the the DT cord-335975-m6lkrehi 2323 26 Tipaza Tipaza NNP cord-335975-m6lkrehi 2323 27 wilaya wilaya NNP cord-335975-m6lkrehi 2323 28 was be VBD cord-335975-m6lkrehi 2323 29 1.1 1.1 CD cord-335975-m6lkrehi 2323 30 100,000 100,000 CD cord-335975-m6lkrehi 2323 31 children child NNS cord-335975-m6lkrehi 2323 32 year year NN cord-335975-m6lkrehi 2323 33 , , , cord-335975-m6lkrehi 2323 34 the the DT cord-335975-m6lkrehi 2323 35 average average JJ cord-335975-m6lkrehi 2323 36 length length NN cord-335975-m6lkrehi 2323 37 of of IN cord-335975-m6lkrehi 2323 38 stay stay NN cord-335975-m6lkrehi 2323 39 in in IN cord-335975-m6lkrehi 2323 40 intensive intensive JJ cord-335975-m6lkrehi 2323 41 care care NN cord-335975-m6lkrehi 2323 42 units unit NNS cord-335975-m6lkrehi 2323 43 was be VBD cord-335975-m6lkrehi 2323 44 22 22 CD cord-335975-m6lkrehi 2323 45 days day NNS cord-335975-m6lkrehi 2323 46 , , , cord-335975-m6lkrehi 2323 47 with with IN cord-335975-m6lkrehi 2323 48 several several JJ cord-335975-m6lkrehi 2323 49 complications complication NNS cord-335975-m6lkrehi 2323 50 of of IN cord-335975-m6lkrehi 2323 51 decubitus decubitus NN cord-335975-m6lkrehi 2323 52 , , , cord-335975-m6lkrehi 2323 53 and and CC cord-335975-m6lkrehi 2323 54 functional functional JJ cord-335975-m6lkrehi 2323 55 due due IN cord-335975-m6lkrehi 2323 56 to to IN cord-335975-m6lkrehi 2323 57 the the DT cord-335975-m6lkrehi 2323 58 primary primary JJ cord-335975-m6lkrehi 2323 59 and and CC cord-335975-m6lkrehi 2323 60 secondary secondary JJ cord-335975-m6lkrehi 2323 61 lesions lesion NNS cord-335975-m6lkrehi 2323 62 of of IN cord-335975-m6lkrehi 2323 63 the the DT cord-335975-m6lkrehi 2323 64 cranial cranial JJ cord-335975-m6lkrehi 2323 65 trauma trauma NN cord-335975-m6lkrehi 2323 66 . . . cord-335975-m6lkrehi 2324 1 The the DT cord-335975-m6lkrehi 2324 2 head head NN cord-335975-m6lkrehi 2324 3 trauma trauma NN cord-335975-m6lkrehi 2324 4 of of IN cord-335975-m6lkrehi 2324 5 the the DT cord-335975-m6lkrehi 2324 6 child child NN cord-335975-m6lkrehi 2324 7 is be VBZ cord-335975-m6lkrehi 2324 8 a a DT cord-335975-m6lkrehi 2324 9 public public JJ cord-335975-m6lkrehi 2324 10 health health NN cord-335975-m6lkrehi 2324 11 problem problem NN cord-335975-m6lkrehi 2324 12 , , , cord-335975-m6lkrehi 2324 13 its -PRON- PRP$ cord-335975-m6lkrehi 2324 14 functional functional JJ cord-335975-m6lkrehi 2324 15 prognosis prognosis NN cord-335975-m6lkrehi 2324 16 can can MD cord-335975-m6lkrehi 2324 17 be be VB cord-335975-m6lkrehi 2324 18 dramatic dramatic JJ cord-335975-m6lkrehi 2324 19 when when WRB cord-335975-m6lkrehi 2324 20 it -PRON- PRP cord-335975-m6lkrehi 2324 21 is be VBZ cord-335975-m6lkrehi 2324 22 severe severe JJ cord-335975-m6lkrehi 2324 23 , , , cord-335975-m6lkrehi 2324 24 its -PRON- PRP$ cord-335975-m6lkrehi 2324 25 management management NN cord-335975-m6lkrehi 2324 26 must must MD cord-335975-m6lkrehi 2324 27 be be VB cord-335975-m6lkrehi 2324 28 early early JJ cord-335975-m6lkrehi 2324 29 and and CC cord-335975-m6lkrehi 2324 30 multidisciplinary multidisciplinary JJ cord-335975-m6lkrehi 2324 31 . . . cord-335975-m6lkrehi 2325 1 Introduction introduction NN cord-335975-m6lkrehi 2325 2 : : : cord-335975-m6lkrehi 2326 1 The the DT cord-335975-m6lkrehi 2326 2 aim aim NN cord-335975-m6lkrehi 2326 3 of of IN cord-335975-m6lkrehi 2326 4 the the DT cord-335975-m6lkrehi 2326 5 study study NN cord-335975-m6lkrehi 2326 6 was be VBD cord-335975-m6lkrehi 2326 7 to to TO cord-335975-m6lkrehi 2326 8 identify identify VB cord-335975-m6lkrehi 2326 9 factors factor NNS cord-335975-m6lkrehi 2326 10 predicting predict VBG cord-335975-m6lkrehi 2326 11 lung lung NN cord-335975-m6lkrehi 2326 12 contusion contusion NN cord-335975-m6lkrehi 2326 13 in in IN cord-335975-m6lkrehi 2326 14 trauma trauma NN cord-335975-m6lkrehi 2326 15 children child NNS cord-335975-m6lkrehi 2326 16 . . . cord-335975-m6lkrehi 2327 1 Patients patient NNS cord-335975-m6lkrehi 2327 2 and and CC cord-335975-m6lkrehi 2327 3 methods method NNS cord-335975-m6lkrehi 2327 4 : : : cord-335975-m6lkrehi 2327 5 Retrospective retrospective JJ cord-335975-m6lkrehi 2327 6 study study NN cord-335975-m6lkrehi 2327 7 conducted conduct VBN cord-335975-m6lkrehi 2327 8 for for IN cord-335975-m6lkrehi 2327 9 a a DT cord-335975-m6lkrehi 2327 10 period period NN cord-335975-m6lkrehi 2327 11 of of IN cord-335975-m6lkrehi 2327 12 8 8 CD cord-335975-m6lkrehi 2327 13 years year NNS cord-335975-m6lkrehi 2327 14 ( ( -LRB- cord-335975-m6lkrehi 2327 15 January January NNP cord-335975-m6lkrehi 2327 16 01 01 CD cord-335975-m6lkrehi 2327 17 , , , cord-335975-m6lkrehi 2327 18 2005-December 2005-december CD cord-335975-m6lkrehi 2327 19 31 31 CD cord-335975-m6lkrehi 2327 20 , , , cord-335975-m6lkrehi 2327 21 2012 2012 CD cord-335975-m6lkrehi 2327 22 ) ) -RRB- cord-335975-m6lkrehi 2327 23 in in IN cord-335975-m6lkrehi 2327 24 a a DT cord-335975-m6lkrehi 2327 25 medical medical JJ cord-335975-m6lkrehi 2327 26 surgical surgical JJ cord-335975-m6lkrehi 2327 27 intensive intensive JJ cord-335975-m6lkrehi 2327 28 care care NN cord-335975-m6lkrehi 2327 29 unit unit NN cord-335975-m6lkrehi 2327 30 . . . cord-335975-m6lkrehi 2328 1 All all DT cord-335975-m6lkrehi 2328 2 trauma trauma NN cord-335975-m6lkrehi 2328 3 patients patient NNS cord-335975-m6lkrehi 2328 4 younger young JJR cord-335975-m6lkrehi 2328 5 than than IN cord-335975-m6lkrehi 2328 6 15 15 CD cord-335975-m6lkrehi 2328 7 years year NNS cord-335975-m6lkrehi 2328 8 were be VBD cord-335975-m6lkrehi 2328 9 included include VBN cord-335975-m6lkrehi 2328 10 . . . cord-335975-m6lkrehi 2329 1 Two two CD cord-335975-m6lkrehi 2329 2 groups group NNS cord-335975-m6lkrehi 2329 3 were be VBD cord-335975-m6lkrehi 2329 4 compared compare VBN cord-335975-m6lkrehi 2329 5 - - : cord-335975-m6lkrehi 2329 6 those those DT cord-335975-m6lkrehi 2329 7 with with IN cord-335975-m6lkrehi 2329 8 lung lung NN cord-335975-m6lkrehi 2329 9 contusions contusion NNS cord-335975-m6lkrehi 2329 10 ( ( -LRB- cord-335975-m6lkrehi 2329 11 C c NN cord-335975-m6lkrehi 2329 12 + + CC cord-335975-m6lkrehi 2329 13 group group NN cord-335975-m6lkrehi 2329 14 ) ) -RRB- cord-335975-m6lkrehi 2329 15 and and CC cord-335975-m6lkrehi 2329 16 those those DT cord-335975-m6lkrehi 2329 17 without without IN cord-335975-m6lkrehi 2329 18 lung lung NN cord-335975-m6lkrehi 2329 19 contusions contusion NNS cord-335975-m6lkrehi 2329 20 ( ( -LRB- cord-335975-m6lkrehi 2329 21 C C NNP cord-335975-m6lkrehi 2329 22 − − NNP cord-335975-m6lkrehi 2329 23 group group NN cord-335975-m6lkrehi 2329 24 ) ) -RRB- cord-335975-m6lkrehi 2329 25 . . . cord-335975-m6lkrehi 2330 1 Results result NNS cord-335975-m6lkrehi 2330 2 : : : cord-335975-m6lkrehi 2331 1 We -PRON- PRP cord-335975-m6lkrehi 2331 2 included include VBD cord-335975-m6lkrehi 2331 3 330 330 CD cord-335975-m6lkrehi 2331 4 patients patient NNS cord-335975-m6lkrehi 2331 5 . . . cord-335975-m6lkrehi 2332 1 The the DT cord-335975-m6lkrehi 2332 2 mean mean JJ cord-335975-m6lkrehi 2332 3 ( ( -LRB- cord-335975-m6lkrehi 2332 4 SD sd NN cord-335975-m6lkrehi 2332 5 ) ) -RRB- cord-335975-m6lkrehi 2332 6 age age NN cord-335975-m6lkrehi 2332 7 was be VBD cord-335975-m6lkrehi 2332 8 7.6 7.6 CD cord-335975-m6lkrehi 2332 9 ( ( -LRB- cord-335975-m6lkrehi 2332 10 4.3 4.3 CD cord-335975-m6lkrehi 2332 11 ) ) -RRB- cord-335975-m6lkrehi 2332 12 years year NNS cord-335975-m6lkrehi 2332 13 . . . cord-335975-m6lkrehi 2333 1 Chest chest NN cord-335975-m6lkrehi 2333 2 injury injury NN cord-335975-m6lkrehi 2333 3 was be VBD cord-335975-m6lkrehi 2333 4 diagnosed diagnose VBN cord-335975-m6lkrehi 2333 5 in in IN cord-335975-m6lkrehi 2333 6 70 70 CD cord-335975-m6lkrehi 2333 7 patients patient NNS cord-335975-m6lkrehi 2333 8 ( ( -LRB- cord-335975-m6lkrehi 2333 9 21.2 21.2 CD cord-335975-m6lkrehi 2333 10 % % NN cord-335975-m6lkrehi 2333 11 ) ) -RRB- cord-335975-m6lkrehi 2333 12 . . . cord-335975-m6lkrehi 2334 1 All all DT cord-335975-m6lkrehi 2334 2 our -PRON- PRP$ cord-335975-m6lkrehi 2334 3 patients patient NNS cord-335975-m6lkrehi 2334 4 needed need VBD cord-335975-m6lkrehi 2334 5 mechanical mechanical JJ cord-335975-m6lkrehi 2334 6 ventilation ventilation NN cord-335975-m6lkrehi 2334 7 . . . cord-335975-m6lkrehi 2335 1 Lung lung NN cord-335975-m6lkrehi 2335 2 contusions contusion NNS cord-335975-m6lkrehi 2335 3 were be VBD cord-335975-m6lkrehi 2335 4 diagnosed diagnose VBN cord-335975-m6lkrehi 2335 5 in43 in43 NNP cord-335975-m6lkrehi 2335 6 patients patient NNS cord-335975-m6lkrehi 2335 7 ( ( -LRB- cord-335975-m6lkrehi 2335 8 13 13 CD cord-335975-m6lkrehi 2335 9 % % NN cord-335975-m6lkrehi 2335 10 of of IN cord-335975-m6lkrehi 2335 11 all all DT cord-335975-m6lkrehi 2335 12 patients patient NNS cord-335975-m6lkrehi 2335 13 and and CC cord-335975-m6lkrehi 2335 14 61.4 61.4 CD cord-335975-m6lkrehi 2335 15 % % NN cord-335975-m6lkrehi 2335 16 of of IN cord-335975-m6lkrehi 2335 17 patients patient NNS cord-335975-m6lkrehi 2335 18 with with IN cord-335975-m6lkrehi 2335 19 chest chest NN cord-335975-m6lkrehi 2335 20 trauma trauma NN cord-335975-m6lkrehi 2335 21 ) ) -RRB- cord-335975-m6lkrehi 2335 22 . . . cord-335975-m6lkrehi 2336 1 In in IN cord-335975-m6lkrehi 2336 2 multivariate multivariate JJ cord-335975-m6lkrehi 2336 3 analysis analysis NN cord-335975-m6lkrehi 2336 4 , , , cord-335975-m6lkrehi 2336 5 independent independent JJ cord-335975-m6lkrehi 2336 6 factors factor NNS cord-335975-m6lkrehi 2336 7 predicting predict VBG cord-335975-m6lkrehi 2336 8 lung lung NN cord-335975-m6lkrehi 2336 9 contusion contusion NN cord-335975-m6lkrehi 2336 10 were be VBD cord-335975-m6lkrehi 2336 11 road road NN cord-335975-m6lkrehi 2336 12 traffic traffic NN cord-335975-m6lkrehi 2336 13 accident accident NN cord-335975-m6lkrehi 2336 14 ( ( -LRB- cord-335975-m6lkrehi 2336 15 odds odd NNS cord-335975-m6lkrehi 2336 16 ratio ratio NN cord-335975-m6lkrehi 2336 17 [ [ -LRB- cord-335975-m6lkrehi 2336 18 OR or CC cord-335975-m6lkrehi 2336 19 ] ] -RRB- cord-335975-m6lkrehi 2336 20 , , , cord-335975-m6lkrehi 2336 21 3.2 3.2 CD cord-335975-m6lkrehi 2336 22 + + SYM cord-335975-m6lkrehi 2336 23 95 95 CD cord-335975-m6lkrehi 2336 24 % % NN cord-335975-m6lkrehi 2336 25 confidence confidence NN cord-335975-m6lkrehi 2336 26 interval interval NN cord-335975-m6lkrehi 2336 27 [ [ -LRB- cord-335975-m6lkrehi 2336 28 CI CI NNP cord-335975-m6lkrehi 2336 29 ] ] -RRB- cord-335975-m6lkrehi 2336 30 , , , cord-335975-m6lkrehi 2336 31 1.2 1.2 CD cord-335975-m6lkrehi 2336 32 - - SYM cord-335975-m6lkrehi 2336 33 8.6 8.6 CD cord-335975-m6lkrehi 2336 34 + + SYM cord-335975-m6lkrehi 2336 35 p p NN cord-335975-m6lkrehi 2336 36 = = SYM cord-335975-m6lkrehi 2336 37 0.019 0.019 CD cord-335975-m6lkrehi 2336 38 ) ) -RRB- cord-335975-m6lkrehi 2336 39 , , , cord-335975-m6lkrehi 2336 40 increased increase VBD cord-335975-m6lkrehi 2336 41 Pediatric Pediatric NNP cord-335975-m6lkrehi 2336 42 Risk Risk NNP cord-335975-m6lkrehi 2336 43 of of IN cord-335975-m6lkrehi 2336 44 Mortality Mortality NNP cord-335975-m6lkrehi 2336 45 ( ( -LRB- cord-335975-m6lkrehi 2336 46 PRISM PRISM NNP cord-335975-m6lkrehi 2336 47 ) ) -RRB- cord-335975-m6lkrehi 2336 48 score score NN cord-335975-m6lkrehi 2336 49 ( ( -LRB- cord-335975-m6lkrehi 2336 50 OR or CC cord-335975-m6lkrehi 2336 51 , , , cord-335975-m6lkrehi 2336 52 1.1 1.1 CD cord-335975-m6lkrehi 2336 53 + + SYM cord-335975-m6lkrehi 2336 54 95 95 CD cord-335975-m6lkrehi 2336 55 % % NN cord-335975-m6lkrehi 2336 56 CI CI NNP cord-335975-m6lkrehi 2336 57 1.1 1.1 CD cord-335975-m6lkrehi 2336 58 - - SYM cord-335975-m6lkrehi 2336 59 1.2 1.2 CD cord-335975-m6lkrehi 2336 60 + + CC cord-335975-m6lkrehi 2336 61 p p NN cord-335975-m6lkrehi 2336 62 = = SYM cord-335975-m6lkrehi 2336 63 0.017 0.017 CD cord-335975-m6lkrehi 2336 64 ) ) -RRB- cord-335975-m6lkrehi 2336 65 , , , cord-335975-m6lkrehi 2336 66 hepatic hepatic JJ cord-335975-m6lkrehi 2336 67 contusion contusion NN cord-335975-m6lkrehi 2336 68 ( ( -LRB- cord-335975-m6lkrehi 2336 69 OR or CC cord-335975-m6lkrehi 2337 1 4.8 4.8 CD cord-335975-m6lkrehi 2337 2 + + SYM cord-335975-m6lkrehi 2337 3 95 95 CD cord-335975-m6lkrehi 2337 4 % % NN cord-335975-m6lkrehi 2337 5 CI CI NNP cord-335975-m6lkrehi 2337 6 1.3 1.3 CD cord-335975-m6lkrehi 2337 7 - - HYPH cord-335975-m6lkrehi 2337 8 17.1 17.1 CD cord-335975-m6lkrehi 2337 9 + + CC cord-335975-m6lkrehi 2337 10 p p NN cord-335975-m6lkrehi 2337 11 = = SYM cord-335975-m6lkrehi 2337 12 0.017 0.017 CD cord-335975-m6lkrehi 2337 13 ) ) -RRB- cord-335975-m6lkrehi 2337 14 , , , cord-335975-m6lkrehi 2337 15 and and CC cord-335975-m6lkrehi 2337 16 pelvic pelvic JJ cord-335975-m6lkrehi 2337 17 ring ring NN cord-335975-m6lkrehi 2337 18 fracture fracture NN cord-335975-m6lkrehi 2337 19 ( ( -LRB- cord-335975-m6lkrehi 2337 20 OR or CC cord-335975-m6lkrehi 2337 21 , , , cord-335975-m6lkrehi 2337 22 3.5 3.5 CD cord-335975-m6lkrehi 2337 23 + + SYM cord-335975-m6lkrehi 2337 24 95 95 CD cord-335975-m6lkrehi 2337 25 % % NN cord-335975-m6lkrehi 2337 26 CI CI NNP cord-335975-m6lkrehi 2337 27 1.1 1.1 CD cord-335975-m6lkrehi 2337 28 - - HYPH cord-335975-m6lkrehi 2337 29 10.5 10.5 CD cord-335975-m6lkrehi 2338 1 + + CC cord-335975-m6lkrehi 2338 2 p p NN cord-335975-m6lkrehi 2338 3 = = SYM cord-335975-m6lkrehi 2338 4 0.026 0.026 CD cord-335975-m6lkrehi 2338 5 ) ) -RRB- cord-335975-m6lkrehi 2338 6 . . . cord-335975-m6lkrehi 2339 1 Death death NN cord-335975-m6lkrehi 2339 2 occurred occur VBD cord-335975-m6lkrehi 2339 3 in in IN cord-335975-m6lkrehi 2339 4 46 46 CD cord-335975-m6lkrehi 2339 5 patients patient NNS cord-335975-m6lkrehi 2339 6 ( ( -LRB- cord-335975-m6lkrehi 2339 7 13.9 13.9 CD cord-335975-m6lkrehi 2339 8 % % NN cord-335975-m6lkrehi 2339 9 ) ) -RRB- cord-335975-m6lkrehi 2339 10 . . . cord-335975-m6lkrehi 2340 1 Intensive intensive JJ cord-335975-m6lkrehi 2340 2 care care NN cord-335975-m6lkrehi 2340 3 unit unit NN cord-335975-m6lkrehi 2340 4 mortality mortality NN cord-335975-m6lkrehi 2340 5 was be VBD cord-335975-m6lkrehi 2340 6 significantly significantly RB cord-335975-m6lkrehi 2340 7 higher high JJR cord-335975-m6lkrehi 2340 8 in in IN cord-335975-m6lkrehi 2340 9 the the DT cord-335975-m6lkrehi 2340 10 C c NN cord-335975-m6lkrehi 2340 11 + + CC cord-335975-m6lkrehi 2340 12 group group NN cord-335975-m6lkrehi 2340 13 ( ( -LRB- cord-335975-m6lkrehi 2340 14 OR or CC cord-335975-m6lkrehi 2340 15 , , , cord-335975-m6lkrehi 2340 16 2.5 2.5 CD cord-335975-m6lkrehi 2340 17 + + SYM cord-335975-m6lkrehi 2340 18 95 95 CD cord-335975-m6lkrehi 2340 19 % % NN cord-335975-m6lkrehi 2340 20 CI CI NNP cord-335975-m6lkrehi 2340 21 1.2 1.2 CD cord-335975-m6lkrehi 2340 22 - - SYM cord-335975-m6lkrehi 2340 23 5.4 5.4 CD cord-335975-m6lkrehi 2340 24 + + SYM cord-335975-m6lkrehi 2340 25 p p NN cord-335975-m6lkrehi 2340 26 = = SYM cord-335975-m6lkrehi 2340 27 0.021 0.021 CD cord-335975-m6lkrehi 2340 28 ) ) -RRB- cord-335975-m6lkrehi 2340 29 . . . cord-335975-m6lkrehi 2341 1 However however RB cord-335975-m6lkrehi 2341 2 , , , cord-335975-m6lkrehi 2341 3 mortality mortality NN cord-335975-m6lkrehi 2341 4 was be VBD cord-335975-m6lkrehi 2341 5 not not RB cord-335975-m6lkrehi 2341 6 differentbetween differentbetween VBN cord-335975-m6lkrehi 2341 7 the the DT cord-335975-m6lkrehi 2341 8 2 2 CD cord-335975-m6lkrehi 2341 9 groups group NNS cord-335975-m6lkrehi 2341 10 after after IN cord-335975-m6lkrehi 2341 11 adjusting adjust VBG cord-335975-m6lkrehi 2341 12 for for IN cord-335975-m6lkrehi 2341 13 PRISM prism NN cord-335975-m6lkrehi 2341 14 score score NN cord-335975-m6lkrehi 2341 15 ( ( -LRB- cord-335975-m6lkrehi 2341 16 OR or RB cord-335975-m6lkrehi 2342 1 , , , cord-335975-m6lkrehi 2342 2 1.2 1.2 CD cord-335975-m6lkrehi 2342 3 + + SYM cord-335975-m6lkrehi 2342 4 95 95 CD cord-335975-m6lkrehi 2342 5 % % NN cord-335975-m6lkrehi 2343 1 CI CI NNP cord-335975-m6lkrehi 2343 2 0.5 0.5 CD cord-335975-m6lkrehi 2343 3 - - HYPH cord-335975-m6lkrehi 2343 4 2.9 2.9 CD cord-335975-m6lkrehi 2343 5 + + CC cord-335975-m6lkrehi 2344 1 p p NN cord-335975-m6lkrehi 2344 2 = = SYM cord-335975-m6lkrehi 2344 3 0.752 0.752 CD cord-335975-m6lkrehi 2344 4 ) ) -RRB- cord-335975-m6lkrehi 2345 1 or or CC cord-335975-m6lkrehi 2345 2 after after IN cord-335975-m6lkrehi 2345 3 adjusting adjust VBG cord-335975-m6lkrehi 2345 4 for for IN cord-335975-m6lkrehi 2345 5 Injury injury NN cord-335975-m6lkrehi 2345 6 Severity severity NN cord-335975-m6lkrehi 2345 7 Score score NN cord-335975-m6lkrehi 2345 8 ( ( -LRB- cord-335975-m6lkrehi 2345 9 OR or CC cord-335975-m6lkrehi 2345 10 , , , cord-335975-m6lkrehi 2345 11 0.7 0.7 CD cord-335975-m6lkrehi 2345 12 + + SYM cord-335975-m6lkrehi 2345 13 95 95 CD cord-335975-m6lkrehi 2345 14 % % NN cord-335975-m6lkrehi 2345 15 CI CI NNP cord-335975-m6lkrehi 2345 16 0.3 0.3 CD cord-335975-m6lkrehi 2345 17 - - SYM cord-335975-m6lkrehi 2345 18 2.1 2.1 CD cord-335975-m6lkrehi 2345 19 + + SYM cord-335975-m6lkrehi 2345 20 p p NN cord-335975-m6lkrehi 2345 21 = = SYM cord-335975-m6lkrehi 2345 22 0.565 0.565 CD cord-335975-m6lkrehi 2345 23 ) ) -RRB- cord-335975-m6lkrehi 2345 24 . . . cord-335975-m6lkrehi 2346 1 Conclusion conclusion NN cord-335975-m6lkrehi 2346 2 : : : cord-335975-m6lkrehi 2347 1 Lung lung NN cord-335975-m6lkrehi 2347 2 contusion contusion NN cord-335975-m6lkrehi 2347 3 is be VBZ cord-335975-m6lkrehi 2347 4 common common JJ cord-335975-m6lkrehi 2347 5 in in IN cord-335975-m6lkrehi 2347 6 critically critically RB cord-335975-m6lkrehi 2347 7 ill ill JJ cord-335975-m6lkrehi 2347 8 children child NNS cord-335975-m6lkrehi 2347 9 with with IN cord-335975-m6lkrehi 2347 10 chest chest NN cord-335975-m6lkrehi 2347 11 trauma trauma NN cord-335975-m6lkrehi 2347 12 . . . cord-335975-m6lkrehi 2348 1 The the DT cord-335975-m6lkrehi 2348 2 diagnosis diagnosis NN cord-335975-m6lkrehi 2348 3 should should MD cord-335975-m6lkrehi 2348 4 be be VB cord-335975-m6lkrehi 2348 5 considered consider VBN cord-335975-m6lkrehi 2348 6 in in IN cord-335975-m6lkrehi 2348 7 patientswith patientswith NN cord-335975-m6lkrehi 2348 8 road road NN cord-335975-m6lkrehi 2348 9 traffic traffic NN cord-335975-m6lkrehi 2348 10 accident accident NN cord-335975-m6lkrehi 2348 11 , , , cord-335975-m6lkrehi 2348 12 increased increase VBN cord-335975-m6lkrehi 2348 13 PRISM PRISM NNP cord-335975-m6lkrehi 2348 14 score score NN cord-335975-m6lkrehi 2348 15 , , , cord-335975-m6lkrehi 2348 16 hepatic hepatic JJ cord-335975-m6lkrehi 2348 17 contusion contusion NN cord-335975-m6lkrehi 2348 18 , , , cord-335975-m6lkrehi 2348 19 and and CC cord-335975-m6lkrehi 2348 20 pelvic pelvic JJ cord-335975-m6lkrehi 2348 21 ring ring NN cord-335975-m6lkrehi 2348 22 fracture fracture NN cord-335975-m6lkrehi 2348 23 . . . cord-335975-m6lkrehi 2349 1 Introduction introduction NN cord-335975-m6lkrehi 2349 2 : : : cord-335975-m6lkrehi 2350 1 Chest chest NN cord-335975-m6lkrehi 2350 2 trauma trauma NN cord-335975-m6lkrehi 2350 3 is be VBZ cord-335975-m6lkrehi 2350 4 often often RB cord-335975-m6lkrehi 2350 5 associated associate VBN cord-335975-m6lkrehi 2350 6 with with IN cord-335975-m6lkrehi 2350 7 pleural pleural JJ cord-335975-m6lkrehi 2350 8 effusion effusion NN cord-335975-m6lkrehi 2350 9 ( ( -LRB- cord-335975-m6lkrehi 2350 10 hemothorax hemothorax NN cord-335975-m6lkrehi 2350 11 and and CC cord-335975-m6lkrehi 2350 12 or or CC cord-335975-m6lkrehi 2350 13 pneumothorax pneumothorax NN cord-335975-m6lkrehi 2350 14 ) ) -RRB- cord-335975-m6lkrehi 2350 15 . . . cord-335975-m6lkrehi 2351 1 Drainage drainage NN cord-335975-m6lkrehi 2351 2 of of IN cord-335975-m6lkrehi 2351 3 the the DT cord-335975-m6lkrehi 2351 4 pleural pleural JJ cord-335975-m6lkrehi 2351 5 space space NN cord-335975-m6lkrehi 2351 6 by by IN cord-335975-m6lkrehi 2351 7 a a DT cord-335975-m6lkrehi 2351 8 chest chest NN cord-335975-m6lkrehi 2351 9 tube tube NN cord-335975-m6lkrehi 2351 10 is be VBZ cord-335975-m6lkrehi 2351 11 a a DT cord-335975-m6lkrehi 2351 12 common common JJ cord-335975-m6lkrehi 2351 13 intervention intervention NN cord-335975-m6lkrehi 2351 14 in in IN cord-335975-m6lkrehi 2351 15 such such JJ cord-335975-m6lkrehi 2351 16 situations situation NNS cord-335975-m6lkrehi 2351 17 . . . cord-335975-m6lkrehi 2352 1 Blunt blunt JJ cord-335975-m6lkrehi 2352 2 dissection dissection NN cord-335975-m6lkrehi 2352 3 technique technique NN cord-335975-m6lkrehi 2352 4 with with IN cord-335975-m6lkrehi 2352 5 a a DT cord-335975-m6lkrehi 2352 6 Kelly Kelly NNP cord-335975-m6lkrehi 2352 7 clamp clamp NN cord-335975-m6lkrehi 2352 8 is be VBZ cord-335975-m6lkrehi 2352 9 preferred prefer VBN cord-335975-m6lkrehi 2352 10 to to IN cord-335975-m6lkrehi 2352 11 classical classical JJ cord-335975-m6lkrehi 2352 12 trocar trocar NN cord-335975-m6lkrehi 2352 13 techniques technique NNS cord-335975-m6lkrehi 2352 14 to to TO cord-335975-m6lkrehi 2352 15 prevent prevent VB cord-335975-m6lkrehi 2352 16 severe severe JJ cord-335975-m6lkrehi 2352 17 complications complication NNS cord-335975-m6lkrehi 2352 18 , , , cord-335975-m6lkrehi 2352 19 like like IN cord-335975-m6lkrehi 2352 20 perforation perforation NN cord-335975-m6lkrehi 2352 21 of of IN cord-335975-m6lkrehi 2352 22 thoracic thoracic JJ cord-335975-m6lkrehi 2352 23 or or CC cord-335975-m6lkrehi 2352 24 abdominal abdominal JJ cord-335975-m6lkrehi 2352 25 organs organ NNS cord-335975-m6lkrehi 2352 26 . . . cord-335975-m6lkrehi 2353 1 Despite despite IN cord-335975-m6lkrehi 2353 2 these these DT cord-335975-m6lkrehi 2353 3 precautions precaution NNS cord-335975-m6lkrehi 2353 4 , , , cord-335975-m6lkrehi 2353 5 malposition malposition NNP cord-335975-m6lkrehi 2353 6 remains remain VBZ cord-335975-m6lkrehi 2353 7 the the DT cord-335975-m6lkrehi 2353 8 most most RBS cord-335975-m6lkrehi 2353 9 common common JJ cord-335975-m6lkrehi 2353 10 complication complication NN cord-335975-m6lkrehi 2353 11 of of IN cord-335975-m6lkrehi 2353 12 tube tube NN cord-335975-m6lkrehi 2353 13 thoracostomy thoracostomy NN cord-335975-m6lkrehi 2353 14 . . . cord-335975-m6lkrehi 2354 1 We -PRON- PRP cord-335975-m6lkrehi 2354 2 investigated investigate VBD cord-335975-m6lkrehi 2354 3 a a DT cord-335975-m6lkrehi 2354 4 new new JJ cord-335975-m6lkrehi 2354 5 technique technique NN cord-335975-m6lkrehi 2354 6 of of IN cord-335975-m6lkrehi 2354 7 bougie bougie NN cord-335975-m6lkrehi 2354 8 - - HYPH cord-335975-m6lkrehi 2354 9 assisted assisted JJ cord-335975-m6lkrehi 2354 10 chest chest NN cord-335975-m6lkrehi 2354 11 tube tube NN cord-335975-m6lkrehi 2354 12 insertion insertion NN cord-335975-m6lkrehi 2354 13 to to TO cord-335975-m6lkrehi 2354 14 prevent prevent VB cord-335975-m6lkrehi 2354 15 chest chest NN cord-335975-m6lkrehi 2354 16 tube tube NN cord-335975-m6lkrehi 2354 17 malposition malposition NN cord-335975-m6lkrehi 2354 18 after after IN cord-335975-m6lkrehi 2354 19 chest chest NN cord-335975-m6lkrehi 2354 20 drainage drainage NN cord-335975-m6lkrehi 2354 21 of of IN cord-335975-m6lkrehi 2354 22 post post JJ cord-335975-m6lkrehi 2354 23 traumatic traumatic JJ cord-335975-m6lkrehi 2354 24 pleural pleural JJ cord-335975-m6lkrehi 2354 25 effusion effusion NN cord-335975-m6lkrehi 2354 26 . . . cord-335975-m6lkrehi 2355 1 Patients patient NNS cord-335975-m6lkrehi 2355 2 and and CC cord-335975-m6lkrehi 2355 3 methods method NNS cord-335975-m6lkrehi 2355 4 : : : cord-335975-m6lkrehi 2355 5 We -PRON- PRP cord-335975-m6lkrehi 2355 6 performed perform VBD cord-335975-m6lkrehi 2355 7 a a DT cord-335975-m6lkrehi 2355 8 controlled control VBN cord-335975-m6lkrehi 2355 9 before before NN cord-335975-m6lkrehi 2355 10 - - HYPH cord-335975-m6lkrehi 2355 11 and and CC cord-335975-m6lkrehi 2355 12 - - HYPH cord-335975-m6lkrehi 2355 13 after after IN cord-335975-m6lkrehi 2355 14 study study NN cord-335975-m6lkrehi 2355 15 to to TO cord-335975-m6lkrehi 2355 16 assess assess VB cord-335975-m6lkrehi 2355 17 the the DT cord-335975-m6lkrehi 2355 18 ability ability NN cord-335975-m6lkrehi 2355 19 of of IN cord-335975-m6lkrehi 2355 20 a a DT cord-335975-m6lkrehi 2355 21 bougie bougie NN cord-335975-m6lkrehi 2355 22 - - HYPH cord-335975-m6lkrehi 2355 23 assisted assisted JJ cord-335975-m6lkrehi 2355 24 chest chest NN cord-335975-m6lkrehi 2355 25 tube tube NN cord-335975-m6lkrehi 2355 26 insertion insertion NN cord-335975-m6lkrehi 2355 27 technique technique NN cord-335975-m6lkrehi 2355 28 , , , cord-335975-m6lkrehi 2355 29 compared compare VBN cord-335975-m6lkrehi 2355 30 to to IN cord-335975-m6lkrehi 2355 31 a a DT cord-335975-m6lkrehi 2355 32 standard standard JJ cord-335975-m6lkrehi 2355 33 blunt blunt JJ cord-335975-m6lkrehi 2355 34 dissection dissection NN cord-335975-m6lkrehi 2355 35 technique technique NN cord-335975-m6lkrehi 2355 36 , , , cord-335975-m6lkrehi 2355 37 to to TO cord-335975-m6lkrehi 2355 38 prevent prevent VB cord-335975-m6lkrehi 2355 39 chest chest NN cord-335975-m6lkrehi 2355 40 tube tube NN cord-335975-m6lkrehi 2355 41 malposition malposition NN cord-335975-m6lkrehi 2355 42 . . . cord-335975-m6lkrehi 2356 1 For for IN cord-335975-m6lkrehi 2356 2 the the DT cord-335975-m6lkrehi 2356 3 bougie bougie NN cord-335975-m6lkrehi 2356 4 - - HYPH cord-335975-m6lkrehi 2356 5 assisted assisted JJ cord-335975-m6lkrehi 2356 6 group group NN cord-335975-m6lkrehi 2356 7 , , , cord-335975-m6lkrehi 2356 8 we -PRON- PRP cord-335975-m6lkrehi 2356 9 used use VBD cord-335975-m6lkrehi 2356 10 a a DT cord-335975-m6lkrehi 2356 11 disposable disposable JJ cord-335975-m6lkrehi 2356 12 Eschmann Eschmann NNP cord-335975-m6lkrehi 2356 13 - - HYPH cord-335975-m6lkrehi 2356 14 style style NN cord-335975-m6lkrehi 2356 15 bougie bougie NN cord-335975-m6lkrehi 2356 16 , , , cord-335975-m6lkrehi 2356 17 commonly commonly RB cord-335975-m6lkrehi 2356 18 used use VBN cord-335975-m6lkrehi 2356 19 to to TO cord-335975-m6lkrehi 2356 20 guide guide VB cord-335975-m6lkrehi 2356 21 the the DT cord-335975-m6lkrehi 2356 22 endotracheal endotracheal NN cord-335975-m6lkrehi 2356 23 tube tube NN cord-335975-m6lkrehi 2356 24 during during IN cord-335975-m6lkrehi 2356 25 difficult difficult JJ cord-335975-m6lkrehi 2356 26 intubations intubation NNS cord-335975-m6lkrehi 2356 27 . . . cord-335975-m6lkrehi 2357 1 Technique technique NN cord-335975-m6lkrehi 2357 2 consisted consist VBN cord-335975-m6lkrehi 2357 3 in in IN cord-335975-m6lkrehi 2357 4 blunt blunt JJ cord-335975-m6lkrehi 2357 5 dissection dissection NN cord-335975-m6lkrehi 2357 6 until until IN cord-335975-m6lkrehi 2357 7 the the DT cord-335975-m6lkrehi 2357 8 parietal parietal JJ cord-335975-m6lkrehi 2357 9 pleura pleura NN cord-335975-m6lkrehi 2357 10 is be VBZ cord-335975-m6lkrehi 2357 11 opened open VBN cord-335975-m6lkrehi 2357 12 . . . cord-335975-m6lkrehi 2358 1 Thoracostomy thoracostomy NN cord-335975-m6lkrehi 2358 2 tube tube NN cord-335975-m6lkrehi 2358 3 was be VBD cord-335975-m6lkrehi 2358 4 preloaded preloade VBN cord-335975-m6lkrehi 2358 5 onto onto IN cord-335975-m6lkrehi 2358 6 the the DT cord-335975-m6lkrehi 2358 7 bougie bougie JJ cord-335975-m6lkrehi 2358 8 and and CC cord-335975-m6lkrehi 2358 9 bougie bougie NNP cord-335975-m6lkrehi 2358 10 was be VBD cord-335975-m6lkrehi 2358 11 advanced advanced JJ cord-335975-m6lkrehi 2358 12 alongside alongside IN cord-335975-m6lkrehi 2358 13 the the DT cord-335975-m6lkrehi 2358 14 finger finger NN cord-335975-m6lkrehi 2358 15 , , , cord-335975-m6lkrehi 2358 16 with with IN cord-335975-m6lkrehi 2358 17 apical apical JJ cord-335975-m6lkrehi 2358 18 or or CC cord-335975-m6lkrehi 2358 19 caudal caudal JJ cord-335975-m6lkrehi 2358 20 direction direction NN cord-335975-m6lkrehi 2358 21 after after IN cord-335975-m6lkrehi 2358 22 entering enter VBG cord-335975-m6lkrehi 2358 23 the the DT cord-335975-m6lkrehi 2358 24 chest chest NN cord-335975-m6lkrehi 2358 25 cavity cavity NN cord-335975-m6lkrehi 2358 26 , , , cord-335975-m6lkrehi 2358 27 depending depend VBG cord-335975-m6lkrehi 2358 28 on on IN cord-335975-m6lkrehi 2358 29 the the DT cord-335975-m6lkrehi 2358 30 type type NN cord-335975-m6lkrehi 2358 31 of of IN cord-335975-m6lkrehi 2358 32 pleural pleural JJ cord-335975-m6lkrehi 2358 33 effusion effusion NN cord-335975-m6lkrehi 2358 34 . . . cord-335975-m6lkrehi 2359 1 Thoracostomy thoracostomy NN cord-335975-m6lkrehi 2359 2 tube tube NN cord-335975-m6lkrehi 2359 3 was be VBD cord-335975-m6lkrehi 2359 4 then then RB cord-335975-m6lkrehi 2359 5 advanced advance VBN cord-335975-m6lkrehi 2359 6 forward forward RB cord-335975-m6lkrehi 2359 7 utilizing utilize VBG cord-335975-m6lkrehi 2359 8 a a DT cord-335975-m6lkrehi 2359 9 Seldinger Seldinger NNP cord-335975-m6lkrehi 2359 10 technique technique NN cord-335975-m6lkrehi 2359 11 . . . cord-335975-m6lkrehi 2360 1 The the DT cord-335975-m6lkrehi 2360 2 primary primary JJ cord-335975-m6lkrehi 2360 3 end end NN cord-335975-m6lkrehi 2360 4 point point NN cord-335975-m6lkrehi 2360 5 was be VBD cord-335975-m6lkrehi 2360 6 optimal optimal JJ cord-335975-m6lkrehi 2360 7 position position NN cord-335975-m6lkrehi 2360 8 of of IN cord-335975-m6lkrehi 2360 9 the the DT cord-335975-m6lkrehi 2360 10 chest chest NN cord-335975-m6lkrehi 2360 11 tube tube NN cord-335975-m6lkrehi 2360 12 . . . cord-335975-m6lkrehi 2361 1 The the DT cord-335975-m6lkrehi 2361 2 tube tube NN cord-335975-m6lkrehi 2361 3 position position NN cord-335975-m6lkrehi 2361 4 was be VBD cord-335975-m6lkrehi 2361 5 blindly blindly RB cord-335975-m6lkrehi 2361 6 assessed assess VBN cord-335975-m6lkrehi 2361 7 on on IN cord-335975-m6lkrehi 2361 8 standard standard JJ cord-335975-m6lkrehi 2361 9 chest chest NN cord-335975-m6lkrehi 2361 10 X x NN cord-335975-m6lkrehi 2361 11 - - NN cord-335975-m6lkrehi 2361 12 ray ray NN cord-335975-m6lkrehi 2361 13 . . . cord-335975-m6lkrehi 2362 1 In in IN cord-335975-m6lkrehi 2362 2 pneumothorax pneumothorax NN cord-335975-m6lkrehi 2362 3 , , , cord-335975-m6lkrehi 2362 4 optimal optimal JJ cord-335975-m6lkrehi 2362 5 position position NN cord-335975-m6lkrehi 2362 6 was be VBD cord-335975-m6lkrehi 2362 7 apical apical JJ cord-335975-m6lkrehi 2362 8 ( ( -LRB- cord-335975-m6lkrehi 2362 9 above above IN cord-335975-m6lkrehi 2362 10 the the DT cord-335975-m6lkrehi 2362 11 aortic aortic JJ cord-335975-m6lkrehi 2362 12 arch arch NN cord-335975-m6lkrehi 2362 13 ) ) -RRB- cord-335975-m6lkrehi 2362 14 , , , cord-335975-m6lkrehi 2362 15 and and CC cord-335975-m6lkrehi 2362 16 in in IN cord-335975-m6lkrehi 2362 17 hemothorax hemothorax NNP cord-335975-m6lkrehi 2362 18 or or CC cord-335975-m6lkrehi 2362 19 mixed mixed JJ cord-335975-m6lkrehi 2362 20 - - HYPH cord-335975-m6lkrehi 2362 21 effusion effusion NN cord-335975-m6lkrehi 2363 1 it -PRON- PRP cord-335975-m6lkrehi 2363 2 was be VBD cord-335975-m6lkrehi 2363 3 basal basal JJ cord-335975-m6lkrehi 2363 4 ( ( -LRB- cord-335975-m6lkrehi 2363 5 2 2 CD cord-335975-m6lkrehi 2363 6 cm cm NNS cord-335975-m6lkrehi 2363 7 above above IN cord-335975-m6lkrehi 2363 8 the the DT cord-335975-m6lkrehi 2363 9 diaphragm diaphragm NN cord-335975-m6lkrehi 2363 10 or or CC cord-335975-m6lkrehi 2363 11 lower low JJR cord-335975-m6lkrehi 2363 12 ) ) -RRB- cord-335975-m6lkrehi 2363 13 . . . cord-335975-m6lkrehi 2364 1 Results result NNS cord-335975-m6lkrehi 2364 2 : : : cord-335975-m6lkrehi 2365 1 A a DT cord-335975-m6lkrehi 2365 2 total total NN cord-335975-m6lkrehi 2365 3 of of IN cord-335975-m6lkrehi 2365 4 58 58 CD cord-335975-m6lkrehi 2365 5 patients patient NNS cord-335975-m6lkrehi 2365 6 were be VBD cord-335975-m6lkrehi 2365 7 enrolled enrol VBN cord-335975-m6lkrehi 2365 8 ( ( -LRB- cord-335975-m6lkrehi 2365 9 bougie bougie NNP cord-335975-m6lkrehi 2365 10 - - HYPH cord-335975-m6lkrehi 2365 11 assistedn assistedn NN cord-335975-m6lkrehi 2366 1 = = SYM cord-335975-m6lkrehi 2366 2 30 30 CD cord-335975-m6lkrehi 2366 3 + + CC cord-335975-m6lkrehi 2366 4 conventional conventional JJ cord-335975-m6lkrehi 2366 5 - - HYPH cord-335975-m6lkrehi 2366 6 n n NN cord-335975-m6lkrehi 2366 7 = = SYM cord-335975-m6lkrehi 2366 8 28 28 CD cord-335975-m6lkrehi 2366 9 ) ) -RRB- cord-335975-m6lkrehi 2366 10 . . . cord-335975-m6lkrehi 2367 1 Chest chest NN cord-335975-m6lkrehi 2367 2 tubes tube NNS cord-335975-m6lkrehi 2367 3 were be VBD cord-335975-m6lkrehi 2367 4 optimally optimally RB cord-335975-m6lkrehi 2367 5 position position NN cord-335975-m6lkrehi 2367 6 in in IN cord-335975-m6lkrehi 2367 7 29 29 CD cord-335975-m6lkrehi 2367 8 ( ( -LRB- cord-335975-m6lkrehi 2367 9 96 96 CD cord-335975-m6lkrehi 2367 10 % % NN cord-335975-m6lkrehi 2367 11 ) ) -RRB- cord-335975-m6lkrehi 2367 12 in in IN cord-335975-m6lkrehi 2367 13 bougie bougie NNP cord-335975-m6lkrehi 2367 14 - - HYPH cord-335975-m6lkrehi 2367 15 assisted assisted JJ cord-335975-m6lkrehi 2367 16 group group NN cord-335975-m6lkrehi 2367 17 and and CC cord-335975-m6lkrehi 2367 18 12 12 CD cord-335975-m6lkrehi 2367 19 ( ( -LRB- cord-335975-m6lkrehi 2367 20 43 43 CD cord-335975-m6lkrehi 2367 21 % % NN cord-335975-m6lkrehi 2367 22 ) ) -RRB- cord-335975-m6lkrehi 2367 23 in in IN cord-335975-m6lkrehi 2367 24 conventional conventional JJ cord-335975-m6lkrehi 2367 25 group group NN cord-335975-m6lkrehi 2367 26 , , , cord-335975-m6lkrehi 2367 27 OR or CC cord-335975-m6lkrehi 2367 28 38.5 38.5 CD cord-335975-m6lkrehi 2367 29 , , , cord-335975-m6lkrehi 2367 30 IC IC NNP cord-335975-m6lkrehi 2367 31 95 95 CD cord-335975-m6lkrehi 2367 32 % % NN cord-335975-m6lkrehi 2367 33 = = NFP cord-335975-m6lkrehi 2367 34 [ [ -LRB- cord-335975-m6lkrehi 2367 35 4.6 4.6 CD cord-335975-m6lkrehi 2367 36 - - SYM cord-335975-m6lkrehi 2367 37 325.16 325.16 CD cord-335975-m6lkrehi 2367 38 ] ] -RRB- cord-335975-m6lkrehi 2367 39 , , , cord-335975-m6lkrehi 2367 40 p p NN cord-335975-m6lkrehi 2367 41 < < XX cord-335975-m6lkrehi 2367 42 0.0001 0.0001 CD cord-335975-m6lkrehi 2367 43 . . . cord-335975-m6lkrehi 2368 1 Efficacy efficacy NN cord-335975-m6lkrehi 2368 2 of of IN cord-335975-m6lkrehi 2368 3 chest chest NN cord-335975-m6lkrehi 2368 4 drainage drainage NN cord-335975-m6lkrehi 2368 5 ( ( -LRB- cord-335975-m6lkrehi 2368 6 defined define VBN cord-335975-m6lkrehi 2368 7 on on IN cord-335975-m6lkrehi 2368 8 chest chest NN cord-335975-m6lkrehi 2368 9 X x NN cord-335975-m6lkrehi 2368 10 - - NN cord-335975-m6lkrehi 2368 11 ray ray NN cord-335975-m6lkrehi 2368 12 as as IN cord-335975-m6lkrehi 2368 13 the the DT cord-335975-m6lkrehi 2368 14 absence absence NN cord-335975-m6lkrehi 2368 15 of of IN cord-335975-m6lkrehi 2368 16 visible visible JJ cord-335975-m6lkrehi 2368 17 pleural pleural JJ cord-335975-m6lkrehi 2368 18 line line NN cord-335975-m6lkrehi 2368 19 for for IN cord-335975-m6lkrehi 2368 20 pneumothorax pneumothorax NN cord-335975-m6lkrehi 2368 21 and and CC cord-335975-m6lkrehi 2368 22 as as IN cord-335975-m6lkrehi 2368 23 a a DT cord-335975-m6lkrehi 2368 24 clear clear JJ cord-335975-m6lkrehi 2368 25 costophrenic costophrenic NN cord-335975-m6lkrehi 2368 26 angle angle NN cord-335975-m6lkrehi 2368 27 for for IN cord-335975-m6lkrehi 2368 28 hemothorax hemothorax NNP cord-335975-m6lkrehi 2368 29 ) ) -RRB- cord-335975-m6lkrehi 2368 30 was be VBD cord-335975-m6lkrehi 2368 31 assessed assess VBN cord-335975-m6lkrehi 2368 32 in in IN cord-335975-m6lkrehi 2368 33 29 29 CD cord-335975-m6lkrehi 2368 34 ( ( -LRB- cord-335975-m6lkrehi 2368 35 96 96 CD cord-335975-m6lkrehi 2368 36 % % NN cord-335975-m6lkrehi 2368 37 ) ) -RRB- cord-335975-m6lkrehi 2368 38 in in IN cord-335975-m6lkrehi 2368 39 bougie bougie NNP cord-335975-m6lkrehi 2368 40 - - HYPH cord-335975-m6lkrehi 2368 41 assisted assisted JJ cord-335975-m6lkrehi 2368 42 group group NN cord-335975-m6lkrehi 2368 43 and and CC cord-335975-m6lkrehi 2368 44 in in IN cord-335975-m6lkrehi 2368 45 15 15 CD cord-335975-m6lkrehi 2368 46 ( ( -LRB- cord-335975-m6lkrehi 2368 47 53 53 CD cord-335975-m6lkrehi 2368 48 % % NN cord-335975-m6lkrehi 2368 49 ) ) -RRB- cord-335975-m6lkrehi 2368 50 in in IN cord-335975-m6lkrehi 2368 51 conventional conventional JJ cord-335975-m6lkrehi 2368 52 group group NN cord-335975-m6lkrehi 2368 53 , , , cord-335975-m6lkrehi 2368 54 OR or CC cord-335975-m6lkrehi 2368 55 25.13 25.13 CD cord-335975-m6lkrehi 2368 56 , , , cord-335975-m6lkrehi 2368 57 IC IC NNP cord-335975-m6lkrehi 2368 58 95 95 CD cord-335975-m6lkrehi 2368 59 % % NN cord-335975-m6lkrehi 2368 60 = = SYM cord-335975-m6lkrehi 2368 61 [ [ -LRB- cord-335975-m6lkrehi 2368 62 3.00 3.00 CD cord-335975-m6lkrehi 2368 63 - - HYPH cord-335975-m6lkrehi 2368 64 210.93 210.93 CD cord-335975-m6lkrehi 2368 65 ] ] -RRB- cord-335975-m6lkrehi 2368 66 , , , cord-335975-m6lkrehi 2368 67 p p NN cord-335975-m6lkrehi 2368 68 < < XX cord-335975-m6lkrehi 2368 69 0.001 0.001 CD cord-335975-m6lkrehi 2368 70 . . . cord-335975-m6lkrehi 2369 1 Average average JJ cord-335975-m6lkrehi 2369 2 procedure procedure NN cord-335975-m6lkrehi 2369 3 time time NN cord-335975-m6lkrehi 2369 4 was be VBD cord-335975-m6lkrehi 2369 5 281 281 CD cord-335975-m6lkrehi 2369 6 s s NNS cord-335975-m6lkrehi 2369 7 ( ( -LRB- cord-335975-m6lkrehi 2369 8 95 95 CD cord-335975-m6lkrehi 2369 9 % % NN cord-335975-m6lkrehi 2369 10 CI CI NNP cord-335975-m6lkrehi 2369 11 120 120 CD cord-335975-m6lkrehi 2369 12 - - HYPH cord-335975-m6lkrehi 2369 13 360 360 CD cord-335975-m6lkrehi 2369 14 s s NNPS cord-335975-m6lkrehi 2369 15 ) ) -RRB- cord-335975-m6lkrehi 2369 16 for for IN cord-335975-m6lkrehi 2369 17 bougieassisted bougieassisted NNP cord-335975-m6lkrehi 2369 18 group group NN cord-335975-m6lkrehi 2369 19 and and CC cord-335975-m6lkrehi 2369 20 558 558 CD cord-335975-m6lkrehi 2369 21 s s NN cord-335975-m6lkrehi 2369 22 ( ( -LRB- cord-335975-m6lkrehi 2369 23 95 95 CD cord-335975-m6lkrehi 2369 24 % % NN cord-335975-m6lkrehi 2369 25 CI CI NNP cord-335975-m6lkrehi 2369 26 318 318 CD cord-335975-m6lkrehi 2369 27 - - HYPH cord-335975-m6lkrehi 2369 28 900 900 CD cord-335975-m6lkrehi 2369 29 s s NNPS cord-335975-m6lkrehi 2369 30 ) ) -RRB- cord-335975-m6lkrehi 2369 31 for for IN cord-335975-m6lkrehi 2369 32 conventional conventional JJ cord-335975-m6lkrehi 2369 33 group group NN cord-335975-m6lkrehi 2369 34 , , , cord-335975-m6lkrehi 2369 35 p p NN cord-335975-m6lkrehi 2369 36 < < XX cord-335975-m6lkrehi 2369 37 0.0001 0.0001 CD cord-335975-m6lkrehi 2369 38 . . . cord-335975-m6lkrehi 2370 1 No no DT cord-335975-m6lkrehi 2370 2 severe severe JJ cord-335975-m6lkrehi 2370 3 complication complication NN cord-335975-m6lkrehi 2370 4 was be VBD cord-335975-m6lkrehi 2370 5 observed observe VBN cord-335975-m6lkrehi 2370 6 in in IN cord-335975-m6lkrehi 2370 7 both both DT cord-335975-m6lkrehi 2370 8 groups group NNS cord-335975-m6lkrehi 2370 9 . . . cord-335975-m6lkrehi 2371 1 Conclusion conclusion NN cord-335975-m6lkrehi 2371 2 : : : cord-335975-m6lkrehi 2371 3 Bougie Bougie NNP cord-335975-m6lkrehi 2371 4 - - HYPH cord-335975-m6lkrehi 2371 5 assisted assist VBN cord-335975-m6lkrehi 2371 6 chest chest NN cord-335975-m6lkrehi 2371 7 tube tube NN cord-335975-m6lkrehi 2371 8 insertion insertion NN cord-335975-m6lkrehi 2371 9 technique technique NN cord-335975-m6lkrehi 2371 10 prevents prevent VBZ cord-335975-m6lkrehi 2371 11 chest chest NN cord-335975-m6lkrehi 2371 12 tube tube NN cord-335975-m6lkrehi 2371 13 malposition malposition NN cord-335975-m6lkrehi 2371 14 , , , cord-335975-m6lkrehi 2371 15 is be VBZ cord-335975-m6lkrehi 2371 16 safe safe JJ cord-335975-m6lkrehi 2371 17 , , , cord-335975-m6lkrehi 2371 18 effective effective JJ cord-335975-m6lkrehi 2371 19 and and CC cord-335975-m6lkrehi 2371 20 shortens shorten VBZ cord-335975-m6lkrehi 2371 21 procedure procedure NN cord-335975-m6lkrehi 2371 22 time time NN cord-335975-m6lkrehi 2371 23 for for IN cord-335975-m6lkrehi 2371 24 the the DT cord-335975-m6lkrehi 2371 25 post post JJ cord-335975-m6lkrehi 2371 26 traumatic traumatic JJ cord-335975-m6lkrehi 2371 27 pleural pleural JJ cord-335975-m6lkrehi 2371 28 effusion effusion NN cord-335975-m6lkrehi 2371 29 drainage drainage NN cord-335975-m6lkrehi 2371 30 . . . cord-335975-m6lkrehi 2372 1 Introduction introduction NN cord-335975-m6lkrehi 2372 2 : : : cord-335975-m6lkrehi 2373 1 Infectious infectious JJ cord-335975-m6lkrehi 2373 2 complications complication NNS cord-335975-m6lkrehi 2373 3 determine determine VBP cord-335975-m6lkrehi 2373 4 the the DT cord-335975-m6lkrehi 2373 5 prognosis prognosis NN cord-335975-m6lkrehi 2373 6 of of IN cord-335975-m6lkrehi 2373 7 burned burn VBN cord-335975-m6lkrehi 2373 8 patients patient NNS cord-335975-m6lkrehi 2373 9 . . . cord-335975-m6lkrehi 2374 1 However however RB cord-335975-m6lkrehi 2374 2 , , , cord-335975-m6lkrehi 2374 3 the the DT cord-335975-m6lkrehi 2374 4 emergence emergence NN cord-335975-m6lkrehi 2374 5 of of IN cord-335975-m6lkrehi 2374 6 bacterial bacterial JJ cord-335975-m6lkrehi 2374 7 resistance resistance NN cord-335975-m6lkrehi 2374 8 to to IN cord-335975-m6lkrehi 2374 9 antibiotics antibiotic NNS cord-335975-m6lkrehi 2374 10 threatens threaten VBZ cord-335975-m6lkrehi 2374 11 treatment treatment NN cord-335975-m6lkrehi 2374 12 efficacy efficacy NN cord-335975-m6lkrehi 2374 13 , , , cord-335975-m6lkrehi 2374 14 which which WDT cord-335975-m6lkrehi 2374 15 is be VBZ cord-335975-m6lkrehi 2374 16 due due JJ cord-335975-m6lkrehi 2374 17 to to IN cord-335975-m6lkrehi 2374 18 an an DT cord-335975-m6lkrehi 2374 19 inadequate inadequate JJ cord-335975-m6lkrehi 2374 20 antibiotic antibiotic JJ cord-335975-m6lkrehi 2374 21 consumption consumption NN cord-335975-m6lkrehi 2374 22 inqualitative inqualitative NN cord-335975-m6lkrehi 2374 23 and and CC cord-335975-m6lkrehi 2374 24 quantitative quantitative JJ cord-335975-m6lkrehi 2374 25 terms term NNS cord-335975-m6lkrehi 2374 26 . . . cord-335975-m6lkrehi 2375 1 The the DT cord-335975-m6lkrehi 2375 2 objective objective NN cord-335975-m6lkrehi 2375 3 of of IN cord-335975-m6lkrehi 2375 4 this this DT cord-335975-m6lkrehi 2375 5 study study NN cord-335975-m6lkrehi 2375 6 was be VBD cord-335975-m6lkrehi 2375 7 to to TO cord-335975-m6lkrehi 2375 8 describe describe VB cord-335975-m6lkrehi 2375 9 the the DT cord-335975-m6lkrehi 2375 10 profil profil NNP cord-335975-m6lkrehi 2375 11 of of IN cord-335975-m6lkrehi 2375 12 consumptionand consumptionand NN cord-335975-m6lkrehi 2375 13 susceptibility susceptibility NN cord-335975-m6lkrehi 2375 14 to to IN cord-335975-m6lkrehi 2375 15 antibiotics antibiotic NNS cord-335975-m6lkrehi 2375 16 . . . cord-335975-m6lkrehi 2376 1 And and CC cord-335975-m6lkrehi 2376 2 , , , cord-335975-m6lkrehi 2376 3 to to TO cord-335975-m6lkrehi 2376 4 explore explore VB cord-335975-m6lkrehi 2376 5 the the DT cord-335975-m6lkrehi 2376 6 predictive predictive JJ cord-335975-m6lkrehi 2376 7 factors factor NNS cord-335975-m6lkrehi 2376 8 for for IN cord-335975-m6lkrehi 2376 9 theemergence theemergence NN cord-335975-m6lkrehi 2376 10 of of IN cord-335975-m6lkrehi 2376 11 MRB MRB NNP cord-335975-m6lkrehi 2376 12 in in IN cord-335975-m6lkrehi 2376 13 the the DT cord-335975-m6lkrehi 2376 14 service service NN cord-335975-m6lkrehi 2376 15 of of IN cord-335975-m6lkrehi 2376 16 burns burn NNS cord-335975-m6lkrehi 2376 17 and and CC cord-335975-m6lkrehi 2376 18 plastic plastic NN cord-335975-m6lkrehi 2376 19 surgery surgery NN cord-335975-m6lkrehi 2376 20 . . . cord-335975-m6lkrehi 2377 1 Patients patient NNS cord-335975-m6lkrehi 2377 2 and and CC cord-335975-m6lkrehi 2377 3 methods method NNS cord-335975-m6lkrehi 2377 4 : : : cord-335975-m6lkrehi 2377 5 It -PRON- PRP cord-335975-m6lkrehi 2377 6 is be VBZ cord-335975-m6lkrehi 2377 7 a a DT cord-335975-m6lkrehi 2377 8 retrospective retrospective JJ cord-335975-m6lkrehi 2377 9 study study NN cord-335975-m6lkrehi 2377 10 including include VBG cord-335975-m6lkrehi 2377 11 122 122 CD cord-335975-m6lkrehi 2377 12 severe severe JJ cord-335975-m6lkrehi 2377 13 burnedpatients burnedpatient NNS cord-335975-m6lkrehi 2377 14 hospitalized hospitalize VBN cord-335975-m6lkrehi 2377 15 for for IN cord-335975-m6lkrehi 2377 16 2 2 CD cord-335975-m6lkrehi 2377 17 years year NNS cord-335975-m6lkrehi 2377 18 in in IN cord-335975-m6lkrehi 2377 19 the the DT cord-335975-m6lkrehi 2377 20 plastic plastic NN cord-335975-m6lkrehi 2377 21 surgery surgery NN cord-335975-m6lkrehi 2377 22 department department NN cord-335975-m6lkrehi 2377 23 of of IN cord-335975-m6lkrehi 2377 24 theuniversity theuniversity NNP cord-335975-m6lkrehi 2377 25 hospital hospital NN cord-335975-m6lkrehi 2377 26 Ibn Ibn NNP cord-335975-m6lkrehi 2377 27 Rochd Rochd NNP cord-335975-m6lkrehi 2377 28 from from IN cord-335975-m6lkrehi 2377 29 January January NNP cord-335975-m6lkrehi 2377 30 2015 2015 CD cord-335975-m6lkrehi 2377 31 to to IN cord-335975-m6lkrehi 2377 32 December December NNP cord-335975-m6lkrehi 2377 33 2016 2016 CD cord-335975-m6lkrehi 2377 34 . . . cord-335975-m6lkrehi 2378 1 Bacterialecology Bacterialecology NNP cord-335975-m6lkrehi 2378 2 was be VBD cord-335975-m6lkrehi 2378 3 described describe VBN cord-335975-m6lkrehi 2378 4 , , , cord-335975-m6lkrehi 2378 5 and and CC cord-335975-m6lkrehi 2378 6 the the DT cord-335975-m6lkrehi 2378 7 distribution distribution NN cord-335975-m6lkrehi 2378 8 of of IN cord-335975-m6lkrehi 2378 9 the the DT cord-335975-m6lkrehi 2378 10 seeds seed NNS cord-335975-m6lkrehi 2378 11 by by IN cord-335975-m6lkrehi 2378 12 group group NN cord-335975-m6lkrehi 2378 13 , , , cord-335975-m6lkrehi 2378 14 by by IN cord-335975-m6lkrehi 2378 15 species specie NNS cord-335975-m6lkrehi 2378 16 andby andby NN cord-335975-m6lkrehi 2378 17 period period NN cord-335975-m6lkrehi 2378 18 of of IN cord-335975-m6lkrehi 2378 19 time time NN cord-335975-m6lkrehi 2378 20 was be VBD cord-335975-m6lkrehi 2378 21 detailed detail VBN cord-335975-m6lkrehi 2378 22 . . . cord-335975-m6lkrehi 2379 1 The the DT cord-335975-m6lkrehi 2379 2 DDD DDD NNP cord-335975-m6lkrehi 2379 3 1000JH 1000jh CD cord-335975-m6lkrehi 2379 4 ( ( -LRB- cord-335975-m6lkrehi 2379 5 daily daily RB cord-335975-m6lkrehi 2379 6 defined define VBN cord-335975-m6lkrehi 2379 7 dosage dosage NN cord-335975-m6lkrehi 2379 8 reportedin reportedin NNP cord-335975-m6lkrehi 2379 9 1000 1000 CD cord-335975-m6lkrehi 2379 10 days day NNS cord-335975-m6lkrehi 2379 11 of of IN cord-335975-m6lkrehi 2379 12 hospitalization hospitalization NN cord-335975-m6lkrehi 2379 13 ) ) -RRB- cord-335975-m6lkrehi 2379 14 was be VBD cord-335975-m6lkrehi 2379 15 used use VBN cord-335975-m6lkrehi 2379 16 to to TO cord-335975-m6lkrehi 2379 17 assess assess VB cord-335975-m6lkrehi 2379 18 the the DT cord-335975-m6lkrehi 2379 19 consumption consumption NN cord-335975-m6lkrehi 2379 20 of of IN cord-335975-m6lkrehi 2379 21 antibiotics antibiotic NNS cord-335975-m6lkrehi 2379 22 . . . cord-335975-m6lkrehi 2380 1 P p NN cord-335975-m6lkrehi 2380 2 correlation correlation NN cord-335975-m6lkrehi 2380 3 coefficients coefficient NNS cord-335975-m6lkrehi 2380 4 were be VBD cord-335975-m6lkrehi 2380 5 calculated calculate VBN cord-335975-m6lkrehi 2380 6 to to TO cord-335975-m6lkrehi 2380 7 explore explore VB cord-335975-m6lkrehi 2380 8 the the DT cord-335975-m6lkrehi 2380 9 association association NN cord-335975-m6lkrehi 2380 10 betweenconsumption betweenconsumption NN cord-335975-m6lkrehi 2380 11 of of IN cord-335975-m6lkrehi 2380 12 antibiotics antibiotic NNS cord-335975-m6lkrehi 2380 13 and and CC cord-335975-m6lkrehi 2380 14 the the DT cord-335975-m6lkrehi 2380 15 emergence emergence NN cord-335975-m6lkrehi 2380 16 of of IN cord-335975-m6lkrehi 2380 17 the the DT cord-335975-m6lkrehi 2380 18 BMR BMR NNP cord-335975-m6lkrehi 2380 19 ( ( -LRB- cord-335975-m6lkrehi 2380 20 Multiresistantbacteria Multiresistantbacteria NNP cord-335975-m6lkrehi 2380 21 ) ) -RRB- cord-335975-m6lkrehi 2380 22 , , , cord-335975-m6lkrehi 2380 23 and and CC cord-335975-m6lkrehi 2380 24 identified identify VBD cord-335975-m6lkrehi 2380 25 predictors predictor NNS cord-335975-m6lkrehi 2380 26 of of IN cord-335975-m6lkrehi 2380 27 this this DT cord-335975-m6lkrehi 2380 28 emergence emergence NN cord-335975-m6lkrehi 2380 29 . . . cord-335975-m6lkrehi 2381 1 Results result NNS cord-335975-m6lkrehi 2381 2 : : : cord-335975-m6lkrehi 2382 1 On on IN cord-335975-m6lkrehi 2382 2 512 512 CD cord-335975-m6lkrehi 2382 3 samples sample NNS cord-335975-m6lkrehi 2382 4 taken take VBN cord-335975-m6lkrehi 2382 5 , , , cord-335975-m6lkrehi 2382 6 539 539 CD cord-335975-m6lkrehi 2382 7 bacterial bacterial JJ cord-335975-m6lkrehi 2382 8 and and CC cord-335975-m6lkrehi 2382 9 fungal fungal JJ cord-335975-m6lkrehi 2382 10 strains strain NNS cord-335975-m6lkrehi 2382 11 were be VBD cord-335975-m6lkrehi 2382 12 identified identify VBN cord-335975-m6lkrehi 2382 13 , , , cord-335975-m6lkrehi 2382 14 with with IN cord-335975-m6lkrehi 2382 15 a a DT cord-335975-m6lkrehi 2382 16 predominance predominance NN cord-335975-m6lkrehi 2382 17 of of IN cord-335975-m6lkrehi 2382 18 P. p. NN cord-335975-m6lkrehi 2382 19 aeruginosa aeruginosa NN cord-335975-m6lkrehi 2382 20 ( ( -LRB- cord-335975-m6lkrehi 2382 21 21.15 21.15 CD cord-335975-m6lkrehi 2382 22 % % NN cord-335975-m6lkrehi 2382 23 ) ) -RRB- cord-335975-m6lkrehi 2382 24 , , , cord-335975-m6lkrehi 2382 25 A. a. NN cord-335975-m6lkrehi 2382 26 baumani baumani NNP cord-335975-m6lkrehi 2383 1 i i PRP cord-335975-m6lkrehi 2383 2 ( ( -LRB- cord-335975-m6lkrehi 2383 3 13 13 CD cord-335975-m6lkrehi 2383 4 % % NN cord-335975-m6lkrehi 2383 5 ) ) -RRB- cord-335975-m6lkrehi 2383 6 and and CC cord-335975-m6lkrehi 2383 7 S. S. NNP cord-335975-m6lkrehi 2383 8 aureu aureu NNP cord-335975-m6lkrehi 2383 9 s s NNP cord-335975-m6lkrehi 2383 10 ( ( -LRB- cord-335975-m6lkrehi 2383 11 13 13 CD cord-335975-m6lkrehi 2383 12 % % NN cord-335975-m6lkrehi 2383 13 ) ) -RRB- cord-335975-m6lkrehi 2383 14 , , . cord-335975-m6lkrehi 2384 1 the the DT cord-335975-m6lkrehi 2384 2 number number NN cord-335975-m6lkrehi 2384 3 of of IN cord-335975-m6lkrehi 2384 4 strains strain NNS cord-335975-m6lkrehi 2384 5 increased increase VBD cord-335975-m6lkrehi 2384 6 with with IN cord-335975-m6lkrehi 2384 7 the the DT cord-335975-m6lkrehi 2384 8 duration duration NN cord-335975-m6lkrehi 2384 9 of of IN cord-335975-m6lkrehi 2384 10 the the DT cord-335975-m6lkrehi 2384 11 stay stay NN cord-335975-m6lkrehi 2384 12 reaching reach VBG cord-335975-m6lkrehi 2384 13 itsmaximum itsmaximum NN cord-335975-m6lkrehi 2384 14 from from IN cord-335975-m6lkrehi 2384 15 28 28 CD cord-335975-m6lkrehi 2384 16 days day NNS cord-335975-m6lkrehi 2384 17 in in IN cord-335975-m6lkrehi 2384 18 hospital hospital NN cord-335975-m6lkrehi 2384 19 . . . cord-335975-m6lkrehi 2385 1 The the DT cord-335975-m6lkrehi 2385 2 ceftazidine ceftazidine NN cord-335975-m6lkrehi 2385 3 ( ( -LRB- cord-335975-m6lkrehi 2385 4 212.7 212.7 CD cord-335975-m6lkrehi 2385 5 DDD DDD NNP cord-335975-m6lkrehi 2385 6 1000DH 1000dh CD cord-335975-m6lkrehi 2385 7 ) ) -RRB- cord-335975-m6lkrehi 2385 8 , , , cord-335975-m6lkrehi 2385 9 imipenem imipenem NNP cord-335975-m6lkrehi 2385 10 ( ( -LRB- cord-335975-m6lkrehi 2385 11 139.7 139.7 CD cord-335975-m6lkrehi 2385 12 DDD DDD NNP cord-335975-m6lkrehi 2385 13 1000DH 1000dh CD cord-335975-m6lkrehi 2385 14 ) ) -RRB- cord-335975-m6lkrehi 2385 15 , , , cord-335975-m6lkrehi 2385 16 and and CC cord-335975-m6lkrehi 2385 17 amikacin amikacin NNS cord-335975-m6lkrehi 2385 18 ( ( -LRB- cord-335975-m6lkrehi 2385 19 122.4 122.4 CD cord-335975-m6lkrehi 2385 20 DDD DDD NNP cord-335975-m6lkrehi 2385 21 1000DH 1000dh CD cord-335975-m6lkrehi 2385 22 ) ) -RRB- cord-335975-m6lkrehi 2385 23 were be VBD cord-335975-m6lkrehi 2385 24 themost themost RBS cord-335975-m6lkrehi 2385 25 used use VBN cord-335975-m6lkrehi 2385 26 antibiotics antibiotic NNS cord-335975-m6lkrehi 2385 27 during during IN cord-335975-m6lkrehi 2385 28 our -PRON- PRP$ cord-335975-m6lkrehi 2385 29 study study NN cord-335975-m6lkrehi 2385 30 , , , cord-335975-m6lkrehi 2385 31 also also RB cord-335975-m6lkrehi 2385 32 + + CC cord-335975-m6lkrehi 2385 33 the the DT cord-335975-m6lkrehi 2385 34 profile profile NN cord-335975-m6lkrehi 2385 35 of of IN cord-335975-m6lkrehi 2385 36 consumption consumption NN cord-335975-m6lkrehi 2386 1 increasedbetween increasedbetween NNP cord-335975-m6lkrehi 2386 2 2015 2015 CD cord-335975-m6lkrehi 2386 3 and and CC cord-335975-m6lkrehi 2386 4 2016.362 2016.362 CD cord-335975-m6lkrehi 2386 5 BMR BMR NNP cord-335975-m6lkrehi 2386 6 were be VBD cord-335975-m6lkrehi 2386 7 isolated isolate VBN cord-335975-m6lkrehi 2387 1 + + CC cord-335975-m6lkrehi 2387 2 the the DT cord-335975-m6lkrehi 2387 3 EBLSE EBLSE NNP cord-335975-m6lkrehi 2387 4 were be VBD cord-335975-m6lkrehi 2387 5 at at IN cord-335975-m6lkrehi 2387 6 the the DT cord-335975-m6lkrehi 2387 7 top top NN cord-335975-m6lkrehi 2387 8 ( ( -LRB- cord-335975-m6lkrehi 2387 9 24.5 24.5 CD cord-335975-m6lkrehi 2387 10 % % NN cord-335975-m6lkrehi 2387 11 ) ) -RRB- cord-335975-m6lkrehi 2388 1 follow follow VB cord-335975-m6lkrehi 2388 2 up up IN cord-335975-m6lkrehi 2388 3 of of IN cord-335975-m6lkrehi 2388 4 theCRPA theCRPA NNP cord-335975-m6lkrehi 2388 5 ( ( -LRB- cord-335975-m6lkrehi 2388 6 21.8 21.8 CD cord-335975-m6lkrehi 2388 7 % % NN cord-335975-m6lkrehi 2388 8 ) ) -RRB- cord-335975-m6lkrehi 2388 9 , , , cord-335975-m6lkrehi 2388 10 followed follow VBN cord-335975-m6lkrehi 2388 11 by by IN cord-335975-m6lkrehi 2388 12 the the DT cord-335975-m6lkrehi 2388 13 IRPA IRPA NNPS cord-335975-m6lkrehi 2388 14 ( ( -LRB- cord-335975-m6lkrehi 2388 15 20.7 20.7 CD cord-335975-m6lkrehi 2388 16 % % NN cord-335975-m6lkrehi 2388 17 ) ) -RRB- cord-335975-m6lkrehi 2388 18 follow follow NN cord-335975-m6lkrehi 2388 19 - - HYPH cord-335975-m6lkrehi 2388 20 up up NN cord-335975-m6lkrehi 2388 21 of of IN cord-335975-m6lkrehi 2388 22 the the DT cord-335975-m6lkrehi 2388 23 CRAB crab NN cord-335975-m6lkrehi 2388 24 ( ( -LRB- cord-335975-m6lkrehi 2388 25 17.1 17.1 CD cord-335975-m6lkrehi 2388 26 % % NN cord-335975-m6lkrehi 2388 27 ) ) -RRB- cord-335975-m6lkrehi 2389 1 then then RB cord-335975-m6lkrehi 2389 2 the the DT cord-335975-m6lkrehi 2389 3 IRAB IRAB NNP cord-335975-m6lkrehi 2389 4 ( ( -LRB- cord-335975-m6lkrehi 2389 5 13.5 13.5 CD cord-335975-m6lkrehi 2389 6 % % NN cord-335975-m6lkrehi 2389 7 ) ) -RRB- cord-335975-m6lkrehi 2389 8 and and CC cord-335975-m6lkrehi 2389 9 finally finally RB cord-335975-m6lkrehi 2389 10 the the DT cord-335975-m6lkrehi 2389 11 MRSA MRSA NNP cord-335975-m6lkrehi 2389 12 with with IN cord-335975-m6lkrehi 2389 13 a a DT cord-335975-m6lkrehi 2389 14 portion portion NN cord-335975-m6lkrehi 2389 15 of of IN cord-335975-m6lkrehi 2389 16 2.2 2.2 CD cord-335975-m6lkrehi 2389 17 % % NN cord-335975-m6lkrehi 2389 18 . . . cord-335975-m6lkrehi 2390 1 The the DT cord-335975-m6lkrehi 2390 2 profile profile NN cord-335975-m6lkrehi 2390 3 of of IN cord-335975-m6lkrehi 2390 4 bacterial bacterial JJ cord-335975-m6lkrehi 2390 5 resistance resistance NN cord-335975-m6lkrehi 2390 6 has have VBZ cord-335975-m6lkrehi 2390 7 varied vary VBN cord-335975-m6lkrehi 2390 8 significantly significantly RB cord-335975-m6lkrehi 2390 9 for for IN cord-335975-m6lkrehi 2390 10 severalantibiotics severalantibiotic NNS cord-335975-m6lkrehi 2390 11 bacteria bacteria NNS cord-335975-m6lkrehi 2390 12 pairs pair NNS cord-335975-m6lkrehi 2390 13 . . . cord-335975-m6lkrehi 2391 1 Conclusion conclusion NN cord-335975-m6lkrehi 2391 2 : : : cord-335975-m6lkrehi 2391 3 It -PRON- PRP cord-335975-m6lkrehi 2391 4 remains remain VBZ cord-335975-m6lkrehi 2391 5 difficult difficult JJ cord-335975-m6lkrehi 2391 6 to to TO cord-335975-m6lkrehi 2391 7 show show VB cord-335975-m6lkrehi 2391 8 correlations correlation NNS cord-335975-m6lkrehi 2391 9 between between IN cord-335975-m6lkrehi 2391 10 antibioticconsumption antibioticconsumption NN cord-335975-m6lkrehi 2391 11 and and CC cord-335975-m6lkrehi 2391 12 bacterial bacterial JJ cord-335975-m6lkrehi 2391 13 resistance resistance NN cord-335975-m6lkrehi 2391 14 . . . cord-335975-m6lkrehi 2392 1 However however RB cord-335975-m6lkrehi 2392 2 , , , cord-335975-m6lkrehi 2392 3 these these DT cord-335975-m6lkrehi 2392 4 data datum NNS cord-335975-m6lkrehi 2392 5 are be VBP cord-335975-m6lkrehi 2392 6 particularly particularly RB cord-335975-m6lkrehi 2392 7 usefulin usefulin NNP cord-335975-m6lkrehi 2392 8 the the DT cord-335975-m6lkrehi 2392 9 epidemiological epidemiological JJ cord-335975-m6lkrehi 2392 10 surveillance surveillance NN cord-335975-m6lkrehi 2392 11 of of IN cord-335975-m6lkrehi 2392 12 bacteria bacteria NNS cord-335975-m6lkrehi 2392 13 to to TO cord-335975-m6lkrehi 2392 14 better well RBR cord-335975-m6lkrehi 2392 15 guide guide VB cord-335975-m6lkrehi 2392 16 probabilisticantibiotic probabilisticantibiotic JJ cord-335975-m6lkrehi 2392 17 therapy therapy NN cord-335975-m6lkrehi 2392 18 . . . cord-335975-m6lkrehi 2393 1 Introduction introduction NN cord-335975-m6lkrehi 2393 2 : : : cord-335975-m6lkrehi 2394 1 Eclampsia Eclampsia NNP cord-335975-m6lkrehi 2394 2 is be VBZ cord-335975-m6lkrehi 2394 3 a a DT cord-335975-m6lkrehi 2394 4 rare rare JJ cord-335975-m6lkrehi 2394 5 but but CC cord-335975-m6lkrehi 2394 6 serious serious JJ cord-335975-m6lkrehi 2394 7 threat threat NN cord-335975-m6lkrehi 2394 8 to to IN cord-335975-m6lkrehi 2394 9 maternal maternal JJ cord-335975-m6lkrehi 2394 10 and and CC cord-335975-m6lkrehi 2394 11 fetal fetal JJ cord-335975-m6lkrehi 2394 12 well well RB cord-335975-m6lkrehi 2394 13 - - HYPH cord-335975-m6lkrehi 2394 14 being being NN cord-335975-m6lkrehi 2394 15 . . . cord-335975-m6lkrehi 2395 1 The the DT cord-335975-m6lkrehi 2395 2 aim aim NN cord-335975-m6lkrehi 2395 3 of of IN cord-335975-m6lkrehi 2395 4 this this DT cord-335975-m6lkrehi 2395 5 study study NN cord-335975-m6lkrehi 2395 6 was be VBD cord-335975-m6lkrehi 2395 7 to to TO cord-335975-m6lkrehi 2395 8 assess assess VB cord-335975-m6lkrehi 2395 9 the the DT cord-335975-m6lkrehi 2395 10 incidence incidence NN cord-335975-m6lkrehi 2395 11 of of IN cord-335975-m6lkrehi 2395 12 eclampsia eclampsia NN cord-335975-m6lkrehi 2395 13 and and CC cord-335975-m6lkrehi 2395 14 its -PRON- PRP$ cord-335975-m6lkrehi 2395 15 morbidity morbidity NN cord-335975-m6lkrehi 2395 16 and and CC cord-335975-m6lkrehi 2395 17 mortality mortality NN cord-335975-m6lkrehi 2395 18 . . . cord-335975-m6lkrehi 2396 1 Patients patient NNS cord-335975-m6lkrehi 2396 2 and and CC cord-335975-m6lkrehi 2396 3 methods method NNS cord-335975-m6lkrehi 2397 1 : : : cord-335975-m6lkrehi 2397 2 We -PRON- PRP cord-335975-m6lkrehi 2397 3 conducted conduct VBD cord-335975-m6lkrehi 2397 4 a a DT cord-335975-m6lkrehi 2397 5 retrospective retrospective JJ cord-335975-m6lkrehi 2397 6 survey survey NN cord-335975-m6lkrehi 2397 7 in in IN cord-335975-m6lkrehi 2397 8 a a DT cord-335975-m6lkrehi 2397 9 third third JJ cord-335975-m6lkrehi 2397 10 level level NN cord-335975-m6lkrehi 2397 11 Tunisian tunisian JJ cord-335975-m6lkrehi 2397 12 university university NN cord-335975-m6lkrehi 2397 13 teaching teaching NN cord-335975-m6lkrehi 2397 14 hospital hospital NN cord-335975-m6lkrehi 2397 15 from from IN cord-335975-m6lkrehi 2397 16 January January NNP cord-335975-m6lkrehi 2397 17 2004 2004 CD cord-335975-m6lkrehi 2397 18 to to IN cord-335975-m6lkrehi 2397 19 December December NNP cord-335975-m6lkrehi 2397 20 2016 2016 CD cord-335975-m6lkrehi 2397 21 . . . cord-335975-m6lkrehi 2398 1 We -PRON- PRP cord-335975-m6lkrehi 2398 2 included include VBD cord-335975-m6lkrehi 2398 3 all all DT cord-335975-m6lkrehi 2398 4 patients patient NNS cord-335975-m6lkrehi 2398 5 with with IN cord-335975-m6lkrehi 2398 6 the the DT cord-335975-m6lkrehi 2398 7 diagnosis diagnosis NN cord-335975-m6lkrehi 2398 8 of of IN cord-335975-m6lkrehi 2398 9 eclampsia eclampsia NN cord-335975-m6lkrehi 2398 10 . . . cord-335975-m6lkrehi 2399 1 Results result NNS cord-335975-m6lkrehi 2399 2 : : : cord-335975-m6lkrehi 2400 1 In in IN cord-335975-m6lkrehi 2400 2 study study NN cord-335975-m6lkrehi 2400 3 period period NN cord-335975-m6lkrehi 2400 4 129847 129847 CD cord-335975-m6lkrehi 2400 5 deliveries delivery NNS cord-335975-m6lkrehi 2400 6 were be VBD cord-335975-m6lkrehi 2400 7 registered register VBN cord-335975-m6lkrehi 2400 8 . . . cord-335975-m6lkrehi 2401 1 83 83 CD cord-335975-m6lkrehi 2401 2 women woman NNS cord-335975-m6lkrehi 2401 3 with with IN cord-335975-m6lkrehi 2401 4 eclampsia eclampsia NN cord-335975-m6lkrehi 2401 5 were be VBD cord-335975-m6lkrehi 2401 6 identified identify VBN cord-335975-m6lkrehi 2401 7 hence hence RB cord-335975-m6lkrehi 2401 8 the the DT cord-335975-m6lkrehi 2401 9 incidence incidence NN cord-335975-m6lkrehi 2401 10 of of IN cord-335975-m6lkrehi 2401 11 eclampsia eclampsia NN cord-335975-m6lkrehi 2401 12 was be VBD cord-335975-m6lkrehi 2401 13 6.39 6.39 CD cord-335975-m6lkrehi 2401 14 per per IN cord-335975-m6lkrehi 2401 15 10000 10000 CD cord-335975-m6lkrehi 2401 16 deliveries delivery NNS cord-335975-m6lkrehi 2401 17 . . . cord-335975-m6lkrehi 2402 1 The the DT cord-335975-m6lkrehi 2402 2 median median JJ cord-335975-m6lkrehi 2402 3 gestational gestational JJ cord-335975-m6lkrehi 2402 4 age age NN cord-335975-m6lkrehi 2402 5 at at IN cord-335975-m6lkrehi 2402 6 the the DT cord-335975-m6lkrehi 2402 7 time time NN cord-335975-m6lkrehi 2402 8 of of IN cord-335975-m6lkrehi 2402 9 eclampsia eclampsia NN cord-335975-m6lkrehi 2402 10 was be VBD cord-335975-m6lkrehi 2402 11 36 36 CD cord-335975-m6lkrehi 2402 12 weeks week NNS cord-335975-m6lkrehi 2402 13 . . . cord-335975-m6lkrehi 2403 1 No no DT cord-335975-m6lkrehi 2403 2 maternal maternal JJ cord-335975-m6lkrehi 2403 3 deaths death NNS cord-335975-m6lkrehi 2403 4 due due JJ cord-335975-m6lkrehi 2403 5 to to IN cord-335975-m6lkrehi 2403 6 eclampsia eclampsia NN cord-335975-m6lkrehi 2403 7 were be VBD cord-335975-m6lkrehi 2403 8 recorded record VBN cord-335975-m6lkrehi 2403 9 . . . cord-335975-m6lkrehi 2404 1 The the DT cord-335975-m6lkrehi 2404 2 delivery delivery NN cord-335975-m6lkrehi 2404 3 mode mode NN cord-335975-m6lkrehi 2404 4 was be VBD cord-335975-m6lkrehi 2404 5 caesarean caesarean JJ cord-335975-m6lkrehi 2404 6 section section NN cord-335975-m6lkrehi 2404 7 in in IN cord-335975-m6lkrehi 2404 8 100 100 CD cord-335975-m6lkrehi 2404 9 % % NN cord-335975-m6lkrehi 2404 10 of of IN cord-335975-m6lkrehi 2404 11 eclamptic eclamptic JJ cord-335975-m6lkrehi 2404 12 patients patient NNS cord-335975-m6lkrehi 2404 13 . . . cord-335975-m6lkrehi 2405 1 The the DT cord-335975-m6lkrehi 2405 2 recurrence recurrence NN cord-335975-m6lkrehi 2405 3 of of IN cord-335975-m6lkrehi 2405 4 eclampsia eclampsia NN cord-335975-m6lkrehi 2405 5 despite despite IN cord-335975-m6lkrehi 2405 6 magnesium magnesium NN cord-335975-m6lkrehi 2405 7 sulfate sulfate NN cord-335975-m6lkrehi 2405 8 prevention prevention NN cord-335975-m6lkrehi 2405 9 was be VBD cord-335975-m6lkrehi 2405 10 observed observe VBN cord-335975-m6lkrehi 2405 11 in in IN cord-335975-m6lkrehi 2405 12 6 6 CD cord-335975-m6lkrehi 2405 13 % % NN cord-335975-m6lkrehi 2405 14 of of IN cord-335975-m6lkrehi 2405 15 patients patient NNS cord-335975-m6lkrehi 2405 16 . . . cord-335975-m6lkrehi 2406 1 Severe severe JJ cord-335975-m6lkrehi 2406 2 complications complication NNS cord-335975-m6lkrehi 2406 3 of of IN cord-335975-m6lkrehi 2406 4 eclampsia eclampsia NN cord-335975-m6lkrehi 2406 5 were be VBD cord-335975-m6lkrehi 2406 6 recorded record VBN cord-335975-m6lkrehi 2406 7 in in IN cord-335975-m6lkrehi 2406 8 10.8 10.8 CD cord-335975-m6lkrehi 2406 9 % % NN cord-335975-m6lkrehi 2406 10 of of IN cord-335975-m6lkrehi 2406 11 patients-4 patients-4 NNP cord-335975-m6lkrehi 2406 12 posterior posterior JJ cord-335975-m6lkrehi 2406 13 reversible reversible JJ cord-335975-m6lkrehi 2406 14 encephalopathy encephalopathy NN cord-335975-m6lkrehi 2406 15 syndrome syndrome NN cord-335975-m6lkrehi 2406 16 , , , cord-335975-m6lkrehi 2406 17 2 2 CD cord-335975-m6lkrehi 2406 18 acute acute JJ cord-335975-m6lkrehi 2406 19 pulmonary pulmonary JJ cord-335975-m6lkrehi 2406 20 edema edema NN cord-335975-m6lkrehi 2406 21 , , , cord-335975-m6lkrehi 2406 22 and and CC cord-335975-m6lkrehi 2406 23 3 3 CD cord-335975-m6lkrehi 2406 24 HELLP HELLP NNP cord-335975-m6lkrehi 2406 25 syndrome syndrome NN cord-335975-m6lkrehi 2406 26 . . . cord-335975-m6lkrehi 2407 1 10.8 10.8 CD cord-335975-m6lkrehi 2407 2 % % NN cord-335975-m6lkrehi 2407 3 of of IN cord-335975-m6lkrehi 2407 4 new new JJ cord-335975-m6lkrehi 2407 5 born bear VBN cord-335975-m6lkrehi 2407 6 were be VBD cord-335975-m6lkrehi 2407 7 preterm preterm NNS cord-335975-m6lkrehi 2407 8 . . . cord-335975-m6lkrehi 2408 1 There there EX cord-335975-m6lkrehi 2408 2 were be VBD cord-335975-m6lkrehi 2408 3 5 5 CD cord-335975-m6lkrehi 2408 4 stillbirths stillbirth NNS cord-335975-m6lkrehi 2408 5 and and CC cord-335975-m6lkrehi 2408 6 2 2 CD cord-335975-m6lkrehi 2408 7 neonatal neonatal JJ cord-335975-m6lkrehi 2408 8 deaths death NNS cord-335975-m6lkrehi 2408 9 . . . cord-335975-m6lkrehi 2409 1 Conclusion conclusion NN cord-335975-m6lkrehi 2409 2 : : : cord-335975-m6lkrehi 2410 1 The the DT cord-335975-m6lkrehi 2410 2 incidence incidence NN cord-335975-m6lkrehi 2410 3 of of IN cord-335975-m6lkrehi 2410 4 eclampsia eclampsia NN cord-335975-m6lkrehi 2410 5 was be VBD cord-335975-m6lkrehi 2410 6 very very RB cord-335975-m6lkrehi 2410 7 high high JJ cord-335975-m6lkrehi 2410 8 probably probably RB cord-335975-m6lkrehi 2410 9 due due JJ cord-335975-m6lkrehi 2410 10 to to IN cord-335975-m6lkrehi 2410 11 center center JJ cord-335975-m6lkrehi 2410 12 effect effect NN cord-335975-m6lkrehi 2410 13 . . . cord-335975-m6lkrehi 2411 1 It -PRON- PRP cord-335975-m6lkrehi 2411 2 's be VBZ cord-335975-m6lkrehi 2411 3 essential essential JJ cord-335975-m6lkrehi 2411 4 to to TO cord-335975-m6lkrehi 2411 5 raise raise VB cord-335975-m6lkrehi 2411 6 awareness awareness NN cord-335975-m6lkrehi 2411 7 among among IN cord-335975-m6lkrehi 2411 8 mothers mother NNS cord-335975-m6lkrehi 2411 9 in in IN cord-335975-m6lkrehi 2411 10 the the DT cord-335975-m6lkrehi 2411 11 community community NN cord-335975-m6lkrehi 2411 12 regarding regard VBG cord-335975-m6lkrehi 2411 13 early early JJ cord-335975-m6lkrehi 2411 14 signs sign NNS cord-335975-m6lkrehi 2411 15 and and CC cord-335975-m6lkrehi 2411 16 symptoms symptom NNS cord-335975-m6lkrehi 2411 17 of of IN cord-335975-m6lkrehi 2411 18 preeclampsia preeclampsia NN cord-335975-m6lkrehi 2411 19 eclampsia eclampsia NN cord-335975-m6lkrehi 2411 20 and and CC cord-335975-m6lkrehi 2411 21 to to TO cord-335975-m6lkrehi 2411 22 design design VB cord-335975-m6lkrehi 2411 23 a a DT cord-335975-m6lkrehi 2411 24 better well JJR cord-335975-m6lkrehi 2411 25 tracking tracking NN cord-335975-m6lkrehi 2411 26 system system NN cord-335975-m6lkrehi 2411 27 for for IN cord-335975-m6lkrehi 2411 28 antenatal antenatal JJ cord-335975-m6lkrehi 2411 29 care care NN cord-335975-m6lkrehi 2411 30 program program NN cord-335975-m6lkrehi 2411 31 . . . cord-335975-m6lkrehi 2412 1 Introduction introduction NN cord-335975-m6lkrehi 2412 2 : : : cord-335975-m6lkrehi 2413 1 To to TO cord-335975-m6lkrehi 2413 2 monitor monitor VB cord-335975-m6lkrehi 2413 3 maternal maternal JJ cord-335975-m6lkrehi 2413 4 mortality mortality NN cord-335975-m6lkrehi 2413 5 which which WDT cord-335975-m6lkrehi 2413 6 is be VBZ cord-335975-m6lkrehi 2413 7 an an DT cord-335975-m6lkrehi 2413 8 indicator indicator NN cord-335975-m6lkrehi 2413 9 of of IN cord-335975-m6lkrehi 2413 10 the the DT cord-335975-m6lkrehi 2413 11 quality quality NN cord-335975-m6lkrehi 2413 12 of of IN cord-335975-m6lkrehi 2413 13 obstetrical obstetrical JJ cord-335975-m6lkrehi 2413 14 care care NN cord-335975-m6lkrehi 2413 15 and and CC cord-335975-m6lkrehi 2413 16 anesthesia anesthesia NN cord-335975-m6lkrehi 2413 17 resuscitation resuscitation NN cord-335975-m6lkrehi 2413 18 , , , cord-335975-m6lkrehi 2413 19 Our -PRON- PRP$ cord-335975-m6lkrehi 2413 20 country country NN cord-335975-m6lkrehi 2413 21 worked work VBD cord-335975-m6lkrehi 2413 22 to to TO cord-335975-m6lkrehi 2413 23 set set VB cord-335975-m6lkrehi 2413 24 up up RP cord-335975-m6lkrehi 2413 25 several several JJ cord-335975-m6lkrehi 2413 26 programs program NNS cord-335975-m6lkrehi 2413 27 targeting target VBG cord-335975-m6lkrehi 2413 28 maternal maternal JJ cord-335975-m6lkrehi 2413 29 and and CC cord-335975-m6lkrehi 2413 30 child child NN cord-335975-m6lkrehi 2413 31 health health NN cord-335975-m6lkrehi 2413 32 . . . cord-335975-m6lkrehi 2414 1 The the DT cord-335975-m6lkrehi 2414 2 aim aim NN cord-335975-m6lkrehi 2414 3 of of IN cord-335975-m6lkrehi 2414 4 this this DT cord-335975-m6lkrehi 2414 5 work work NN cord-335975-m6lkrehi 2414 6 was be VBD cord-335975-m6lkrehi 2414 7 - - : cord-335975-m6lkrehi 2414 8 To to TO cord-335975-m6lkrehi 2414 9 evaluate evaluate VB cord-335975-m6lkrehi 2414 10 the the DT cord-335975-m6lkrehi 2414 11 maternal maternal JJ cord-335975-m6lkrehi 2414 12 mortality mortality NN cord-335975-m6lkrehi 2414 13 rate rate NN cord-335975-m6lkrehi 2414 14 in in IN cord-335975-m6lkrehi 2414 15 our -PRON- PRP$ cord-335975-m6lkrehi 2414 16 department department NN cord-335975-m6lkrehi 2414 17 and and CC cord-335975-m6lkrehi 2414 18 its -PRON- PRP$ cord-335975-m6lkrehi 2414 19 evolution evolution NN cord-335975-m6lkrehi 2414 20 . . . cord-335975-m6lkrehi 2415 1 To to TO cord-335975-m6lkrehi 2415 2 Identify identify VB cord-335975-m6lkrehi 2415 3 the the DT cord-335975-m6lkrehi 2415 4 cause cause NN cord-335975-m6lkrehi 2415 5 of of IN cord-335975-m6lkrehi 2415 6 death death NN cord-335975-m6lkrehi 2415 7 and and CC cord-335975-m6lkrehi 2415 8 classify classify VB cord-335975-m6lkrehi 2415 9 it -PRON- PRP cord-335975-m6lkrehi 2415 10 depending depend VBG cord-335975-m6lkrehi 2415 11 on on IN cord-335975-m6lkrehi 2415 12 whether whether IN cord-335975-m6lkrehi 2415 13 it -PRON- PRP cord-335975-m6lkrehi 2415 14 is be VBZ cord-335975-m6lkrehi 2415 15 preventable preventable JJ cord-335975-m6lkrehi 2415 16 or or CC cord-335975-m6lkrehi 2415 17 not not RB cord-335975-m6lkrehi 2415 18 . . . cord-335975-m6lkrehi 2416 1 To to TO cord-335975-m6lkrehi 2416 2 spot spot VB cord-335975-m6lkrehi 2416 3 the the DT cord-335975-m6lkrehi 2416 4 deficiencies deficiency NNS cord-335975-m6lkrehi 2416 5 either either CC cord-335975-m6lkrehi 2416 6 in in IN cord-335975-m6lkrehi 2416 7 the the DT cord-335975-m6lkrehi 2416 8 care care NN cord-335975-m6lkrehi 2416 9 management management NN cord-335975-m6lkrehi 2416 10 or or CC cord-335975-m6lkrehi 2416 11 the the DT cord-335975-m6lkrehi 2416 12 organization organization NN cord-335975-m6lkrehi 2416 13 of of IN cord-335975-m6lkrehi 2416 14 the the DT cord-335975-m6lkrehi 2416 15 care care NN cord-335975-m6lkrehi 2416 16 system system NN cord-335975-m6lkrehi 2416 17 . . . cord-335975-m6lkrehi 2417 1 To to TO cord-335975-m6lkrehi 2417 2 propose propose VB cord-335975-m6lkrehi 2417 3 ways way NNS cord-335975-m6lkrehi 2417 4 to to TO cord-335975-m6lkrehi 2417 5 improve improve VB cord-335975-m6lkrehi 2417 6 our -PRON- PRP$ cord-335975-m6lkrehi 2417 7 care care NN cord-335975-m6lkrehi 2417 8 and and CC cord-335975-m6lkrehi 2417 9 to to TO cord-335975-m6lkrehi 2417 10 fill fill VB cord-335975-m6lkrehi 2417 11 the the DT cord-335975-m6lkrehi 2417 12 failures failure NNS cord-335975-m6lkrehi 2417 13 . . . cord-335975-m6lkrehi 2418 1 Patients patient NNS cord-335975-m6lkrehi 2418 2 and and CC cord-335975-m6lkrehi 2418 3 methods method NNS cord-335975-m6lkrehi 2418 4 : : : cord-335975-m6lkrehi 2418 5 It -PRON- PRP cord-335975-m6lkrehi 2418 6 was be VBD cord-335975-m6lkrehi 2418 7 a a DT cord-335975-m6lkrehi 2418 8 retrospective retrospective JJ cord-335975-m6lkrehi 2418 9 study study NN cord-335975-m6lkrehi 2418 10 about about IN cord-335975-m6lkrehi 2418 11 maternal maternal JJ cord-335975-m6lkrehi 2418 12 death death NN cord-335975-m6lkrehi 2418 13 , , , cord-335975-m6lkrehi 2418 14 performed perform VBN cord-335975-m6lkrehi 2418 15 at at IN cord-335975-m6lkrehi 2418 16 the the DT cord-335975-m6lkrehi 2418 17 Department Department NNP cord-335975-m6lkrehi 2418 18 of of IN cord-335975-m6lkrehi 2418 19 Gynecology Gynecology NNP cord-335975-m6lkrehi 2418 20 and and CC cord-335975-m6lkrehi 2418 21 Obstetrics Obstetrics NNP cord-335975-m6lkrehi 2418 22 , , , cord-335975-m6lkrehi 2418 23 over over IN cord-335975-m6lkrehi 2418 24 a a DT cord-335975-m6lkrehi 2418 25 25-year 25-year JJ cord-335975-m6lkrehi 2418 26 period period NN cord-335975-m6lkrehi 2418 27 ( ( -LRB- cord-335975-m6lkrehi 2418 28 from from IN cord-335975-m6lkrehi 2418 29 1990 1990 CD cord-335975-m6lkrehi 2418 30 to to IN cord-335975-m6lkrehi 2418 31 2015 2015 CD cord-335975-m6lkrehi 2418 32 ) ) -RRB- cord-335975-m6lkrehi 2418 33 , , , cord-335975-m6lkrehi 2418 34 that that WDT cord-335975-m6lkrehi 2418 35 have have VBP cord-335975-m6lkrehi 2418 36 reported report VBN cord-335975-m6lkrehi 2418 37 14 14 CD cord-335975-m6lkrehi 2418 38 cases case NNS cord-335975-m6lkrehi 2418 39 of of IN cord-335975-m6lkrehi 2418 40 maternal maternal JJ cord-335975-m6lkrehi 2418 41 death death NN cord-335975-m6lkrehi 2418 42 according accord VBG cord-335975-m6lkrehi 2418 43 to to IN cord-335975-m6lkrehi 2418 44 the the DT cord-335975-m6lkrehi 2418 45 World World NNP cord-335975-m6lkrehi 2418 46 Health Health NNP cord-335975-m6lkrehi 2418 47 Organization Organization NNP cord-335975-m6lkrehi 2418 48 definition definition NN cord-335975-m6lkrehi 2418 49 . . . cord-335975-m6lkrehi 2419 1 Results result NNS cord-335975-m6lkrehi 2419 2 : : : cord-335975-m6lkrehi 2420 1 The the DT cord-335975-m6lkrehi 2420 2 Maternal Maternal NNP cord-335975-m6lkrehi 2420 3 Mortality Mortality NNP cord-335975-m6lkrehi 2420 4 Rate Rate NNP cord-335975-m6lkrehi 2420 5 ( ( -LRB- cord-335975-m6lkrehi 2420 6 MMR MMR NNP cord-335975-m6lkrehi 2420 7 ) ) -RRB- cord-335975-m6lkrehi 2420 8 was be VBD cord-335975-m6lkrehi 2420 9 22.43 22.43 CD cord-335975-m6lkrehi 2420 10 for for IN cord-335975-m6lkrehi 2420 11 every every DT cord-335975-m6lkrehi 2420 12 100,000 100,000 CD cord-335975-m6lkrehi 2420 13 live live JJ cord-335975-m6lkrehi 2420 14 births birth NNS cord-335975-m6lkrehi 2420 15 . . . cord-335975-m6lkrehi 2421 1 The the DT cord-335975-m6lkrehi 2421 2 average average JJ cord-335975-m6lkrehi 2421 3 age age NN cord-335975-m6lkrehi 2421 4 of of IN cord-335975-m6lkrehi 2421 5 our -PRON- PRP$ cord-335975-m6lkrehi 2421 6 patients patient NNS cord-335975-m6lkrehi 2421 7 was be VBD cord-335975-m6lkrehi 2421 8 32.3 32.3 CD cord-335975-m6lkrehi 2421 9 years year NNS cord-335975-m6lkrehi 2421 10 . . . cord-335975-m6lkrehi 2422 1 The the DT cord-335975-m6lkrehi 2422 2 main main JJ cord-335975-m6lkrehi 2422 3 risk risk NN cord-335975-m6lkrehi 2422 4 factors factor NNS cord-335975-m6lkrehi 2422 5 for for IN cord-335975-m6lkrehi 2422 6 maternal maternal JJ cord-335975-m6lkrehi 2422 7 mortality mortality NN cord-335975-m6lkrehi 2422 8 are be VBP cord-335975-m6lkrehi 2422 9 unfavorable unfavorable JJ cord-335975-m6lkrehi 2422 10 socioeconomic socioeconomic JJ cord-335975-m6lkrehi 2422 11 conditions condition NNS cord-335975-m6lkrehi 2422 12 , , , cord-335975-m6lkrehi 2422 13 high high JJ cord-335975-m6lkrehi 2422 14 - - HYPH cord-335975-m6lkrehi 2422 15 risk risk NN cord-335975-m6lkrehi 2422 16 pregnancies pregnancy NNS cord-335975-m6lkrehi 2422 17 , , , cord-335975-m6lkrehi 2422 18 multiparity multiparity NN cord-335975-m6lkrehi 2422 19 , , , cord-335975-m6lkrehi 2422 20 primiparity primiparity NN cord-335975-m6lkrehi 2422 21 and and CC cord-335975-m6lkrehi 2422 22 a a DT cord-335975-m6lkrehi 2422 23 poor poor JJ cord-335975-m6lkrehi 2422 24 follow follow NN cord-335975-m6lkrehi 2422 25 - - HYPH cord-335975-m6lkrehi 2422 26 up up NN cord-335975-m6lkrehi 2422 27 of of IN cord-335975-m6lkrehi 2422 28 the the DT cord-335975-m6lkrehi 2422 29 pregnancy pregnancy NN cord-335975-m6lkrehi 2422 30 . . . cord-335975-m6lkrehi 2423 1 The the DT cord-335975-m6lkrehi 2423 2 main main JJ cord-335975-m6lkrehi 2423 3 causes cause NNS cord-335975-m6lkrehi 2423 4 of of IN cord-335975-m6lkrehi 2423 5 maternal maternal JJ cord-335975-m6lkrehi 2423 6 death death NN cord-335975-m6lkrehi 2423 7 are be VBP cord-335975-m6lkrehi 2423 8 represented represent VBN cord-335975-m6lkrehi 2423 9 by by IN cord-335975-m6lkrehi 2423 10 direct direct JJ cord-335975-m6lkrehi 2423 11 obstetric obstetric JJ cord-335975-m6lkrehi 2423 12 causes cause NNS cord-335975-m6lkrehi 2423 13 ( ( -LRB- cord-335975-m6lkrehi 2423 14 80 80 CD cord-335975-m6lkrehi 2423 15 % % NN cord-335975-m6lkrehi 2423 16 ) ) -RRB- cord-335975-m6lkrehi 2423 17 allocated allocate VBN cord-335975-m6lkrehi 2423 18 as as IN cord-335975-m6lkrehi 2423 19 followspostpartum followspostpartum NN cord-335975-m6lkrehi 2423 20 hemorrhage hemorrhage NN cord-335975-m6lkrehi 2423 21 ( ( -LRB- cord-335975-m6lkrehi 2423 22 45 45 CD cord-335975-m6lkrehi 2423 23 % % NN cord-335975-m6lkrehi 2423 24 ) ) -RRB- cord-335975-m6lkrehi 2423 25 , , , cord-335975-m6lkrehi 2423 26 pregnancy pregnancy NN cord-335975-m6lkrehi 2423 27 toxemia toxemia NN cord-335975-m6lkrehi 2423 28 ( ( -LRB- cord-335975-m6lkrehi 2423 29 14 14 CD cord-335975-m6lkrehi 2423 30 % % NN cord-335975-m6lkrehi 2423 31 ) ) -RRB- cord-335975-m6lkrehi 2423 32 , , , cord-335975-m6lkrehi 2423 33 acute acute JJ cord-335975-m6lkrehi 2423 34 fat fat JJ cord-335975-m6lkrehi 2423 35 hepatic hepatic JJ cord-335975-m6lkrehi 2423 36 steatosis steatosis NN cord-335975-m6lkrehi 2423 37 ( ( -LRB- cord-335975-m6lkrehi 2423 38 7 7 CD cord-335975-m6lkrehi 2423 39 % % NN cord-335975-m6lkrehi 2423 40 ) ) -RRB- cord-335975-m6lkrehi 2423 41 , , , cord-335975-m6lkrehi 2423 42 infection infection NN cord-335975-m6lkrehi 2423 43 ( ( -LRB- cord-335975-m6lkrehi 2423 44 7 7 CD cord-335975-m6lkrehi 2423 45 % % NN cord-335975-m6lkrehi 2423 46 ) ) -RRB- cord-335975-m6lkrehi 2423 47 and and CC cord-335975-m6lkrehi 2423 48 complications complication NNS cord-335975-m6lkrehi 2423 49 of of IN cord-335975-m6lkrehi 2423 50 anesthesia anesthesia NN cord-335975-m6lkrehi 2423 51 ( ( -LRB- cord-335975-m6lkrehi 2423 52 7 7 CD cord-335975-m6lkrehi 2423 53 % % NN cord-335975-m6lkrehi 2423 54 ) ) -RRB- cord-335975-m6lkrehi 2423 55 . . . cord-335975-m6lkrehi 2424 1 Indirect indirect JJ cord-335975-m6lkrehi 2424 2 obstetric obstetric JJ cord-335975-m6lkrehi 2424 3 causes cause NNS cord-335975-m6lkrehi 2424 4 were be VBD cord-335975-m6lkrehi 2424 5 found find VBN cord-335975-m6lkrehi 2424 6 in in IN cord-335975-m6lkrehi 2424 7 20 20 CD cord-335975-m6lkrehi 2424 8 % % NN cord-335975-m6lkrehi 2424 9 of of IN cord-335975-m6lkrehi 2424 10 deaths death NNS cord-335975-m6lkrehi 2424 11 . . . cord-335975-m6lkrehi 2425 1 Death death NN cord-335975-m6lkrehi 2425 2 was be VBD cord-335975-m6lkrehi 2425 3 considered consider VBN cord-335975-m6lkrehi 2425 4 avoidable avoidable JJ cord-335975-m6lkrehi 2425 5 in in IN cord-335975-m6lkrehi 2425 6 78.58 78.58 CD cord-335975-m6lkrehi 2425 7 % % NN cord-335975-m6lkrehi 2425 8 of of IN cord-335975-m6lkrehi 2425 9 cases case NNS cord-335975-m6lkrehi 2425 10 . . . cord-335975-m6lkrehi 2426 1 Conclusion conclusion NN cord-335975-m6lkrehi 2426 2 : : : cord-335975-m6lkrehi 2427 1 At at IN cord-335975-m6lkrehi 2427 2 the the DT cord-335975-m6lkrehi 2427 3 end end NN cord-335975-m6lkrehi 2427 4 of of IN cord-335975-m6lkrehi 2427 5 this this DT cord-335975-m6lkrehi 2427 6 work work NN cord-335975-m6lkrehi 2427 7 , , , cord-335975-m6lkrehi 2427 8 we -PRON- PRP cord-335975-m6lkrehi 2427 9 were be VBD cord-335975-m6lkrehi 2427 10 able able JJ cord-335975-m6lkrehi 2427 11 to to TO cord-335975-m6lkrehi 2427 12 pull pull VB cord-335975-m6lkrehi 2427 13 several several JJ cord-335975-m6lkrehi 2427 14 recommendations recommendation NNS cord-335975-m6lkrehi 2427 15 in in IN cord-335975-m6lkrehi 2427 16 order order NN cord-335975-m6lkrehi 2427 17 to to TO cord-335975-m6lkrehi 2427 18 reduce reduce VB cord-335975-m6lkrehi 2427 19 M.M.R. M.M.R. NNP cord-335975-m6lkrehi 2427 20 Health Health NNP cord-335975-m6lkrehi 2427 21 education education NN cord-335975-m6lkrehi 2427 22 . . . cord-335975-m6lkrehi 2428 1 Facilitate facilitate VB cord-335975-m6lkrehi 2428 2 access access NN cord-335975-m6lkrehi 2428 3 to to TO cord-335975-m6lkrehi 2428 4 care care VB cord-335975-m6lkrehi 2428 5 for for IN cord-335975-m6lkrehi 2428 6 the the DT cord-335975-m6lkrehi 2428 7 parturient parturient NN cord-335975-m6lkrehi 2428 8 , , , cord-335975-m6lkrehi 2428 9 improve improve VB cord-335975-m6lkrehi 2428 10 care care NN cord-335975-m6lkrehi 2428 11 and and CC cord-335975-m6lkrehi 2428 12 conditions condition NNS cord-335975-m6lkrehi 2428 13 of of IN cord-335975-m6lkrehi 2428 14 childbirth childbirth NN cord-335975-m6lkrehi 2428 15 . . . cord-335975-m6lkrehi 2429 1 Continuous continuous JJ cord-335975-m6lkrehi 2429 2 training training NN cord-335975-m6lkrehi 2429 3 of of IN cord-335975-m6lkrehi 2429 4 the the DT cord-335975-m6lkrehi 2429 5 medical medical JJ cord-335975-m6lkrehi 2429 6 and and CC cord-335975-m6lkrehi 2429 7 paramedical paramedical JJ cord-335975-m6lkrehi 2429 8 staff staff NN cord-335975-m6lkrehi 2429 9 . . . cord-335975-m6lkrehi 2429 10 _SP cord-335975-m6lkrehi 2430 1 Introduction introduction NN cord-335975-m6lkrehi 2430 2 : : : cord-335975-m6lkrehi 2431 1 Mechanical mechanical JJ cord-335975-m6lkrehi 2431 2 ventilation ventilation NN cord-335975-m6lkrehi 2431 3 can can MD cord-335975-m6lkrehi 2431 4 help help VB cord-335975-m6lkrehi 2431 5 improve improve VB cord-335975-m6lkrehi 2431 6 the the DT cord-335975-m6lkrehi 2431 7 prognosis prognosis NN cord-335975-m6lkrehi 2431 8 of of IN cord-335975-m6lkrehi 2431 9 sepsis sepsis NN cord-335975-m6lkrehi 2431 10 . . . cord-335975-m6lkrehi 2432 1 While while IN cord-335975-m6lkrehi 2432 2 adequate adequate JJ cord-335975-m6lkrehi 2432 3 delivery delivery NN cord-335975-m6lkrehi 2432 4 of of IN cord-335975-m6lkrehi 2432 5 oxygen oxygen NN cord-335975-m6lkrehi 2432 6 to to IN cord-335975-m6lkrehi 2432 7 tissue tissue NN cord-335975-m6lkrehi 2432 8 is be VBZ cord-335975-m6lkrehi 2432 9 crucial crucial JJ cord-335975-m6lkrehi 2432 10 , , , cord-335975-m6lkrehi 2432 11 hyperoxemia hyperoxemia NNP cord-335975-m6lkrehi 2432 12 may may MD cord-335975-m6lkrehi 2432 13 be be VB cord-335975-m6lkrehi 2432 14 deleterious deleterious JJ cord-335975-m6lkrehi 2432 15 . . . cord-335975-m6lkrehi 2433 1 Invasive invasive JJ cord-335975-m6lkrehi 2433 2 out out RB cord-335975-m6lkrehi 2433 3 - - HYPH cord-335975-m6lkrehi 2433 4 of of IN cord-335975-m6lkrehi 2433 5 - - HYPH cord-335975-m6lkrehi 2433 6 hospital hospital NN cord-335975-m6lkrehi 2433 7 ventilation ventilation NN cord-335975-m6lkrehi 2433 8 is be VBZ cord-335975-m6lkrehi 2433 9 often often RB cord-335975-m6lkrehi 2433 10 promptly promptly RB cord-335975-m6lkrehi 2433 11 performed perform VBN cord-335975-m6lkrehi 2433 12 in in IN cord-335975-m6lkrehi 2433 13 life life NN cord-335975-m6lkrehi 2433 14 - - HYPH cord-335975-m6lkrehi 2433 15 threatening threaten VBG cord-335975-m6lkrehi 2433 16 emergencies emergency NNS cord-335975-m6lkrehi 2433 17 . . . cord-335975-m6lkrehi 2434 1 We -PRON- PRP cord-335975-m6lkrehi 2434 2 propose propose VBP cord-335975-m6lkrehi 2434 3 to to TO cord-335975-m6lkrehi 2434 4 determine determine VB cord-335975-m6lkrehi 2434 5 whether whether IN cord-335975-m6lkrehi 2434 6 the the DT cord-335975-m6lkrehi 2434 7 arterial arterial JJ cord-335975-m6lkrehi 2434 8 oxygen oxygen NN cord-335975-m6lkrehi 2434 9 pressure pressure NN cord-335975-m6lkrehi 2434 10 ( ( -LRB- cord-335975-m6lkrehi 2434 11 PaO2 pao2 NN cord-335975-m6lkrehi 2434 12 ) ) -RRB- cord-335975-m6lkrehi 2434 13 at at IN cord-335975-m6lkrehi 2434 14 intensive intensive JJ cord-335975-m6lkrehi 2434 15 care care NN cord-335975-m6lkrehi 2434 16 unit unit NN cord-335975-m6lkrehi 2435 1 ( ( -LRB- cord-335975-m6lkrehi 2435 2 ICU ICU NNP cord-335975-m6lkrehi 2435 3 ) ) -RRB- cord-335975-m6lkrehi 2435 4 admission admission NN cord-335975-m6lkrehi 2435 5 affects affect VBZ cord-335975-m6lkrehi 2435 6 mortality mortality NN cord-335975-m6lkrehi 2435 7 at at IN cord-335975-m6lkrehi 2435 8 day day NN cord-335975-m6lkrehi 2435 9 28 28 CD cord-335975-m6lkrehi 2435 10 ( ( -LRB- cord-335975-m6lkrehi 2435 11 D28 D28 NNP cord-335975-m6lkrehi 2435 12 ) ) -RRB- cord-335975-m6lkrehi 2435 13 in in IN cord-335975-m6lkrehi 2435 14 patients patient NNS cord-335975-m6lkrehi 2435 15 with with IN cord-335975-m6lkrehi 2435 16 septic septic JJ cord-335975-m6lkrehi 2435 17 shock shock NN cord-335975-m6lkrehi 2435 18 subjected subject VBN cord-335975-m6lkrehi 2435 19 to to IN cord-335975-m6lkrehi 2435 20 mechanical mechanical JJ cord-335975-m6lkrehi 2435 21 out out RB cord-335975-m6lkrehi 2435 22 - - HYPH cord-335975-m6lkrehi 2435 23 of of IN cord-335975-m6lkrehi 2435 24 - - HYPH cord-335975-m6lkrehi 2435 25 hospital hospital NN cord-335975-m6lkrehi 2435 26 ventilation ventilation NN cord-335975-m6lkrehi 2435 27 . . . cord-335975-m6lkrehi 2436 1 Patients patient NNS cord-335975-m6lkrehi 2436 2 and and CC cord-335975-m6lkrehi 2436 3 methods method NNS cord-335975-m6lkrehi 2436 4 : : : cord-335975-m6lkrehi 2436 5 We -PRON- PRP cord-335975-m6lkrehi 2436 6 performed perform VBD cord-335975-m6lkrehi 2436 7 a a DT cord-335975-m6lkrehi 2436 8 monocentric monocentric JJ cord-335975-m6lkrehi 2436 9 retrospective retrospective JJ cord-335975-m6lkrehi 2436 10 observational observational JJ cord-335975-m6lkrehi 2436 11 study study NN cord-335975-m6lkrehi 2436 12 on on IN cord-335975-m6lkrehi 2436 13 77 77 CD cord-335975-m6lkrehi 2436 14 patients patient NNS cord-335975-m6lkrehi 2436 15 with with IN cord-335975-m6lkrehi 2436 16 septic septic JJ cord-335975-m6lkrehi 2436 17 shock shock NN cord-335975-m6lkrehi 2436 18 admitted admit VBN cord-335975-m6lkrehi 2436 19 to to IN cord-335975-m6lkrehi 2436 20 the the DT cord-335975-m6lkrehi 2436 21 ICU ICU NNP cord-335975-m6lkrehi 2436 22 . . . cord-335975-m6lkrehi 2437 1 PaO2 PaO2 NNP cord-335975-m6lkrehi 2437 2 was be VBD cord-335975-m6lkrehi 2437 3 measured measure VBN cord-335975-m6lkrehi 2437 4 at at IN cord-335975-m6lkrehi 2437 5 ICU ICU NNP cord-335975-m6lkrehi 2437 6 admission admission NN cord-335975-m6lkrehi 2437 7 in in IN cord-335975-m6lkrehi 2437 8 patients patient NNS cord-335975-m6lkrehi 2437 9 subjected subject VBN cord-335975-m6lkrehi 2437 10 to to IN cord-335975-m6lkrehi 2437 11 invasive invasive JJ cord-335975-m6lkrehi 2437 12 ventilation ventilation NN cord-335975-m6lkrehi 2437 13 before before IN cord-335975-m6lkrehi 2437 14 any any DT cord-335975-m6lkrehi 2437 15 hospital hospital NN cord-335975-m6lkrehi 2437 16 admission admission NN cord-335975-m6lkrehi 2437 17 . . . cord-335975-m6lkrehi 2438 1 The the DT cord-335975-m6lkrehi 2438 2 primary primary JJ cord-335975-m6lkrehi 2438 3 outcome outcome NN cord-335975-m6lkrehi 2438 4 was be VBD cord-335975-m6lkrehi 2438 5 mortality mortality NN cord-335975-m6lkrehi 2438 6 at at IN cord-335975-m6lkrehi 2438 7 day day NN cord-335975-m6lkrehi 2438 8 28 28 CD cord-335975-m6lkrehi 2438 9 ( ( -LRB- cord-335975-m6lkrehi 2438 10 D28 D28 NNP cord-335975-m6lkrehi 2438 11 ) ) -RRB- cord-335975-m6lkrehi 2438 12 . . . cord-335975-m6lkrehi 2439 1 Results result NNS cord-335975-m6lkrehi 2439 2 : : : cord-335975-m6lkrehi 2440 1 Forty forty CD cord-335975-m6lkrehi 2440 2 - - HYPH cord-335975-m6lkrehi 2440 3 nine nine CD cord-335975-m6lkrehi 2440 4 ( ( -LRB- cord-335975-m6lkrehi 2440 5 64 64 CD cord-335975-m6lkrehi 2440 6 % % NN cord-335975-m6lkrehi 2440 7 ) ) -RRB- cord-335975-m6lkrehi 2440 8 patients patient NNS cord-335975-m6lkrehi 2440 9 with with IN cord-335975-m6lkrehi 2440 10 septic septic JJ cord-335975-m6lkrehi 2440 11 shock shock NN cord-335975-m6lkrehi 2440 12 were be VBD cord-335975-m6lkrehi 2440 13 mechanically mechanically RB cord-335975-m6lkrehi 2440 14 ventilated ventilate VBN cord-335975-m6lkrehi 2440 15 before before IN cord-335975-m6lkrehi 2440 16 any any DT cord-335975-m6lkrehi 2440 17 hospital hospital NN cord-335975-m6lkrehi 2440 18 admission admission NN cord-335975-m6lkrehi 2440 19 and and CC cord-335975-m6lkrehi 2440 20 transferred transfer VBN cord-335975-m6lkrehi 2440 21 to to IN cord-335975-m6lkrehi 2440 22 the the DT cord-335975-m6lkrehi 2440 23 ICU ICU NNP cord-335975-m6lkrehi 2440 24 . . . cord-335975-m6lkrehi 2441 1 The the DT cord-335975-m6lkrehi 2441 2 mean mean JJ cord-335975-m6lkrehi 2441 3 PaO2 PaO2 NNS cord-335975-m6lkrehi 2441 4 at at IN cord-335975-m6lkrehi 2441 5 ICU ICU NNP cord-335975-m6lkrehi 2441 6 admission admission NN cord-335975-m6lkrehi 2441 7 was be VBD cord-335975-m6lkrehi 2441 8 153 153 CD cord-335975-m6lkrehi 2441 9 ± ± CD cord-335975-m6lkrehi 2441 10 77 77 CD cord-335975-m6lkrehi 2441 11 and and CC cord-335975-m6lkrehi 2441 12 202 202 CD cord-335975-m6lkrehi 2441 13 ± ± CD cord-335975-m6lkrehi 2441 14 82 82 CD cord-335975-m6lkrehi 2441 15 mmHg mmHg NNS cord-335975-m6lkrehi 2441 16 for for IN cord-335975-m6lkrehi 2441 17 alive alive JJ cord-335975-m6lkrehi 2441 18 and and CC cord-335975-m6lkrehi 2441 19 deceased deceased JJ cord-335975-m6lkrehi 2441 20 patients patient NNS cord-335975-m6lkrehi 2441 21 at at IN cord-335975-m6lkrehi 2441 22 D28 D28 NNP cord-335975-m6lkrehi 2441 23 , , , cord-335975-m6lkrehi 2441 24 respectively respectively RB cord-335975-m6lkrehi 2441 25 . . . cord-335975-m6lkrehi 2442 1 PaO2 PaO2 NNS cord-335975-m6lkrehi 2442 2 was be VBD cord-335975-m6lkrehi 2442 3 significantly significantly RB cord-335975-m6lkrehi 2442 4 associated associate VBN cord-335975-m6lkrehi 2442 5 with with IN cord-335975-m6lkrehi 2442 6 mortality mortality NN cord-335975-m6lkrehi 2442 7 at at IN cord-335975-m6lkrehi 2442 8 D28 D28 NNP cord-335975-m6lkrehi 2442 9 ( ( -LRB- cord-335975-m6lkrehi 2442 10 p p NN cord-335975-m6lkrehi 2442 11 = = SYM cord-335975-m6lkrehi 2442 12 0.04 0.04 CD cord-335975-m6lkrehi 2442 13 ) ) -RRB- cord-335975-m6lkrehi 2442 14 . . . cord-335975-m6lkrehi 2443 1 Using use VBG cord-335975-m6lkrehi 2443 2 a a DT cord-335975-m6lkrehi 2443 3 ROC ROC NNP cord-335975-m6lkrehi 2443 4 curve curve NN cord-335975-m6lkrehi 2443 5 , , , cord-335975-m6lkrehi 2443 6 the the DT cord-335975-m6lkrehi 2443 7 corresponding corresponding JJ cord-335975-m6lkrehi 2443 8 AUC AUC NNP cord-335975-m6lkrehi 2443 9 was be VBD cord-335975-m6lkrehi 2443 10 0.70 0.70 CD cord-335975-m6lkrehi 2443 11 [ [ -LRB- cord-335975-m6lkrehi 2443 12 0.54 0.54 CD cord-335975-m6lkrehi 2443 13 - - SYM cord-335975-m6lkrehi 2443 14 0.85 0.85 CD cord-335975-m6lkrehi 2443 15 ] ] -RRB- cord-335975-m6lkrehi 2443 16 . . . cord-335975-m6lkrehi 2444 1 For for IN cord-335975-m6lkrehi 2444 2 a a DT cord-335975-m6lkrehi 2444 3 PaO2 pao2 NN cord-335975-m6lkrehi 2444 4 > > SYM cord-335975-m6lkrehi 2444 5 150 150 CD cord-335975-m6lkrehi 2444 6 mmHg mmHg NNS cord-335975-m6lkrehi 2444 7 , , , cord-335975-m6lkrehi 2444 8 the the DT cord-335975-m6lkrehi 2444 9 OR or CC cord-335975-m6lkrehi 2444 10 for for IN cord-335975-m6lkrehi 2444 11 mortality mortality NN cord-335975-m6lkrehi 2444 12 at at IN cord-335975-m6lkrehi 2444 13 D28 D28 NNP cord-335975-m6lkrehi 2444 14 was be VBD cord-335975-m6lkrehi 2444 15 4.20 4.20 CD cord-335975-m6lkrehi 2444 16 [ [ -LRB- cord-335975-m6lkrehi 2444 17 1.25 1.25 CD cord-335975-m6lkrehi 2444 18 - - SYM cord-335975-m6lkrehi 2444 19 15 15 CD cord-335975-m6lkrehi 2444 20 .95 .95 CD cord-335975-m6lkrehi 2444 21 ] ] -RRB- cord-335975-m6lkrehi 2445 1 ( ( -LRB- cord-335975-m6lkrehi 2445 2 p p NN cord-335975-m6lkrehi 2445 3 = = SYM cord-335975-m6lkrehi 2445 4 0.02 0.02 CD cord-335975-m6lkrehi 2445 5 ) ) -RRB- cord-335975-m6lkrehi 2445 6 , , , cord-335975-m6lkrehi 2445 7 whereas whereas IN cord-335975-m6lkrehi 2445 8 for for IN cord-335975-m6lkrehi 2445 9 a a DT cord-335975-m6lkrehi 2445 10 PaO2 pao2 NN cord-335975-m6lkrehi 2445 11 < < XX cord-335975-m6lkrehi 2445 12 150 150 CD cord-335975-m6lkrehi 2445 13 mmHg mmHg NNS cord-335975-m6lkrehi 2445 14 , , , cord-335975-m6lkrehi 2445 15 the the DT cord-335975-m6lkrehi 2445 16 OR OR NNP cord-335975-m6lkrehi 2445 17 was be VBD cord-335975-m6lkrehi 2445 18 0.24 0.24 CD cord-335975-m6lkrehi 2445 19 [ [ -LRB- cord-335975-m6lkrehi 2445 20 0.06 0.06 CD cord-335975-m6lkrehi 2445 21 - - HYPH cord-335975-m6lkrehi 2445 22 0.80 0.80 CD cord-335975-m6lkrehi 2445 23 ] ] -RRB- cord-335975-m6lkrehi 2446 1 ( ( -LRB- cord-335975-m6lkrehi 2446 2 p p NN cord-335975-m6lkrehi 2446 3 = = SYM cord-335975-m6lkrehi 2446 4 0.02 0.02 CD cord-335975-m6lkrehi 2446 5 ) ) -RRB- cord-335975-m6lkrehi 2446 6 . . . cord-335975-m6lkrehi 2447 1 Conclusion conclusion NN cord-335975-m6lkrehi 2447 2 : : : cord-335975-m6lkrehi 2448 1 In in IN cord-335975-m6lkrehi 2448 2 this this DT cord-335975-m6lkrehi 2448 3 study study NN cord-335975-m6lkrehi 2448 4 , , , cord-335975-m6lkrehi 2448 5 we -PRON- PRP cord-335975-m6lkrehi 2448 6 report report VBP cord-335975-m6lkrehi 2448 7 a a DT cord-335975-m6lkrehi 2448 8 significant significant JJ cord-335975-m6lkrehi 2448 9 association association NN cord-335975-m6lkrehi 2448 10 between between IN cord-335975-m6lkrehi 2448 11 hyperoxemia hyperoxemia NNP cord-335975-m6lkrehi 2448 12 at at IN cord-335975-m6lkrehi 2448 13 ICU ICU NNP cord-335975-m6lkrehi 2448 14 admission admission NN cord-335975-m6lkrehi 2448 15 and and CC cord-335975-m6lkrehi 2448 16 mortality mortality NN cord-335975-m6lkrehi 2448 17 at at IN cord-335975-m6lkrehi 2448 18 D28 D28 NNP cord-335975-m6lkrehi 2448 19 in in IN cord-335975-m6lkrehi 2448 20 patients patient NNS cord-335975-m6lkrehi 2448 21 with with IN cord-335975-m6lkrehi 2448 22 septic septic JJ cord-335975-m6lkrehi 2448 23 shock shock NN cord-335975-m6lkrehi 2448 24 subjected subject VBN cord-335975-m6lkrehi 2448 25 to to IN cord-335975-m6lkrehi 2448 26 pre pre VB cord-335975-m6lkrehi 2448 27 - - JJ cord-335975-m6lkrehi 2448 28 hospital hospital JJ cord-335975-m6lkrehi 2448 29 invasive invasive JJ cord-335975-m6lkrehi 2448 30 mechanical mechanical JJ cord-335975-m6lkrehi 2448 31 ventilation ventilation NN cord-335975-m6lkrehi 2448 32 . . . cord-335975-m6lkrehi 2449 1 The the DT cord-335975-m6lkrehi 2449 2 adjustment adjustment NN cord-335975-m6lkrehi 2449 3 of of IN cord-335975-m6lkrehi 2449 4 the the DT cord-335975-m6lkrehi 2449 5 PaO2 PaO2 NNS cord-335975-m6lkrehi 2449 6 is be VBZ cord-335975-m6lkrehi 2449 7 a a DT cord-335975-m6lkrehi 2449 8 crucial crucial JJ cord-335975-m6lkrehi 2449 9 prognosis prognosis NN cord-335975-m6lkrehi 2449 10 factor factor NN cord-335975-m6lkrehi 2449 11 in in IN cord-335975-m6lkrehi 2449 12 patients patient NNS cord-335975-m6lkrehi 2449 13 with with IN cord-335975-m6lkrehi 2449 14 septic septic JJ cord-335975-m6lkrehi 2449 15 shock shock NN cord-335975-m6lkrehi 2449 16 subjected subject VBN cord-335975-m6lkrehi 2449 17 to to IN cord-335975-m6lkrehi 2449 18 invasive invasive JJ cord-335975-m6lkrehi 2449 19 out out RP cord-335975-m6lkrehi 2449 20 - - HYPH cord-335975-m6lkrehi 2449 21 of of IN cord-335975-m6lkrehi 2449 22 - - HYPH cord-335975-m6lkrehi 2449 23 hospital hospital NN cord-335975-m6lkrehi 2449 24 ventilation ventilation NN cord-335975-m6lkrehi 2449 25 to to TO cord-335975-m6lkrehi 2449 26 avoid avoid VB cord-335975-m6lkrehi 2449 27 the the DT cord-335975-m6lkrehi 2449 28 toxic toxic JJ cord-335975-m6lkrehi 2449 29 effects effect NNS cord-335975-m6lkrehi 2449 30 of of IN cord-335975-m6lkrehi 2449 31 hyperoxemia hyperoxemia NN cord-335975-m6lkrehi 2449 32 . . . cord-335975-m6lkrehi 2450 1 However however RB cord-335975-m6lkrehi 2450 2 , , , cord-335975-m6lkrehi 2450 3 blood blood NN cord-335975-m6lkrehi 2450 4 gazometry gazometry NN cord-335975-m6lkrehi 2450 5 is be VBZ cord-335975-m6lkrehi 2450 6 hard hard JJ cord-335975-m6lkrehi 2450 7 to to TO cord-335975-m6lkrehi 2450 8 get get VB cord-335975-m6lkrehi 2450 9 in in IN cord-335975-m6lkrehi 2450 10 a a DT cord-335975-m6lkrehi 2450 11 prehospital prehospital JJ cord-335975-m6lkrehi 2450 12 setting setting NN cord-335975-m6lkrehi 2450 13 . . . cord-335975-m6lkrehi 2451 1 Consequently consequently RB cord-335975-m6lkrehi 2451 2 , , , cord-335975-m6lkrehi 2451 3 alternative alternative JJ cord-335975-m6lkrehi 2451 4 and and CC cord-335975-m6lkrehi 2451 5 feasible feasible JJ cord-335975-m6lkrehi 2451 6 measures measure NNS cord-335975-m6lkrehi 2451 7 are be VBP cord-335975-m6lkrehi 2451 8 needed need VBN cord-335975-m6lkrehi 2451 9 , , , cord-335975-m6lkrehi 2451 10 such such JJ cord-335975-m6lkrehi 2451 11 as as IN cord-335975-m6lkrehi 2451 12 pulse pulse NN cord-335975-m6lkrehi 2451 13 oximetry oximetry NN cord-335975-m6lkrehi 2451 14 , , , cord-335975-m6lkrehi 2451 15 to to TO cord-335975-m6lkrehi 2451 16 improve improve VB cord-335975-m6lkrehi 2451 17 the the DT cord-335975-m6lkrehi 2451 18 management management NN cord-335975-m6lkrehi 2451 19 of of IN cord-335975-m6lkrehi 2451 20 prehospital prehospital JJ cord-335975-m6lkrehi 2451 21 invasive invasive JJ cord-335975-m6lkrehi 2451 22 ventilation ventilation NN cord-335975-m6lkrehi 2451 23 . . . cord-335975-m6lkrehi 2452 1 Introduction introduction NN cord-335975-m6lkrehi 2452 2 : : : cord-335975-m6lkrehi 2453 1 Nowadays nowadays RB cord-335975-m6lkrehi 2453 2 , , , cord-335975-m6lkrehi 2453 3 benefit benefit NN cord-335975-m6lkrehi 2453 4 of of IN cord-335975-m6lkrehi 2453 5 enhanced enhance VBN cord-335975-m6lkrehi 2453 6 CT CT NNP cord-335975-m6lkrehi 2453 7 - - NN cord-335975-m6lkrehi 2453 8 scan scan NN cord-335975-m6lkrehi 2453 9 in in IN cord-335975-m6lkrehi 2453 10 positive positive JJ cord-335975-m6lkrehi 2453 11 diagnosis diagnosis NN cord-335975-m6lkrehi 2453 12 of of IN cord-335975-m6lkrehi 2453 13 acute acute JJ cord-335975-m6lkrehi 2453 14 pulmonary pulmonary JJ cord-335975-m6lkrehi 2453 15 embolism embolism NN cord-335975-m6lkrehi 2453 16 ( ( -LRB- cord-335975-m6lkrehi 2453 17 PE PE NNP cord-335975-m6lkrehi 2453 18 ) ) -RRB- cord-335975-m6lkrehi 2453 19 is be VBZ cord-335975-m6lkrehi 2453 20 well well RB cord-335975-m6lkrehi 2453 21 established establish VBN cord-335975-m6lkrehi 2453 22 . . . cord-335975-m6lkrehi 2454 1 It -PRON- PRP cord-335975-m6lkrehi 2454 2 also also RB cord-335975-m6lkrehi 2454 3 allows allow VBZ cord-335975-m6lkrehi 2454 4 evaluation evaluation NN cord-335975-m6lkrehi 2454 5 of of IN cord-335975-m6lkrehi 2454 6 PE PE NNP cord-335975-m6lkrehi 2454 7 's 's POS cord-335975-m6lkrehi 2454 8 burden burden NN cord-335975-m6lkrehi 2454 9 on on IN cord-335975-m6lkrehi 2454 10 the the DT cord-335975-m6lkrehi 2454 11 right right JJ cord-335975-m6lkrehi 2454 12 heart heart NN cord-335975-m6lkrehi 2454 13 and and CC cord-335975-m6lkrehi 2454 14 shows show VBZ cord-335975-m6lkrehi 2454 15 several several JJ cord-335975-m6lkrehi 2454 16 signs sign NNS cord-335975-m6lkrehi 2454 17 of of IN cord-335975-m6lkrehi 2454 18 acute acute JJ cord-335975-m6lkrehi 2454 19 cor cor JJ cord-335975-m6lkrehi 2454 20 pulmonale pulmonale NN cord-335975-m6lkrehi 2454 21 ( ( -LRB- cord-335975-m6lkrehi 2454 22 ACP ACP NNP cord-335975-m6lkrehi 2454 23 ) ) -RRB- cord-335975-m6lkrehi 2454 24 . . . cord-335975-m6lkrehi 2455 1 Objectives objective NNS cord-335975-m6lkrehi 2455 2 -We -We : cord-335975-m6lkrehi 2455 3 aimed aim VBN cord-335975-m6lkrehi 2455 4 to to TO cord-335975-m6lkrehi 2455 5 assess assess VB cord-335975-m6lkrehi 2455 6 benefits benefit NNS cord-335975-m6lkrehi 2455 7 of of IN cord-335975-m6lkrehi 2455 8 control control NN cord-335975-m6lkrehi 2456 1 CT CT NNP cord-335975-m6lkrehi 2456 2 - - HYPH cord-335975-m6lkrehi 2456 3 scan scan JJ cord-335975-m6lkrehi 2456 4 24 24 CD cord-335975-m6lkrehi 2456 5 h h NN cord-335975-m6lkrehi 2456 6 after after IN cord-335975-m6lkrehi 2456 7 thrombolysis thrombolysis NN cord-335975-m6lkrehi 2456 8 in in IN cord-335975-m6lkrehi 2456 9 acute acute JJ cord-335975-m6lkrehi 2456 10 PE PE NNP cord-335975-m6lkrehi 2456 11 . . . cord-335975-m6lkrehi 2457 1 Patients patient NNS cord-335975-m6lkrehi 2457 2 and and CC cord-335975-m6lkrehi 2457 3 methods method NNS cord-335975-m6lkrehi 2457 4 : : : cord-335975-m6lkrehi 2457 5 We -PRON- PRP cord-335975-m6lkrehi 2457 6 retrospectively retrospectively RB cord-335975-m6lkrehi 2457 7 enrolled enrol VBD cord-335975-m6lkrehi 2457 8 patients patient NNS cord-335975-m6lkrehi 2457 9 with with IN cord-335975-m6lkrehi 2457 10 confirmed confirm VBN cord-335975-m6lkrehi 2457 11 PE PE NNP cord-335975-m6lkrehi 2457 12 whom whom WP cord-335975-m6lkrehi 2457 13 have have VBP cord-335975-m6lkrehi 2457 14 been be VBN cord-335975-m6lkrehi 2457 15 thrombolysed thrombolyse VBN cord-335975-m6lkrehi 2457 16 between between IN cord-335975-m6lkrehi 2457 17 January January NNP cord-335975-m6lkrehi 2457 18 2014 2014 CD cord-335975-m6lkrehi 2457 19 and and CC cord-335975-m6lkrehi 2457 20 August August NNP cord-335975-m6lkrehi 2457 21 2017 2017 CD cord-335975-m6lkrehi 2457 22 and and CC cord-335975-m6lkrehi 2457 23 controled control VBN cord-335975-m6lkrehi 2457 24 with with IN cord-335975-m6lkrehi 2457 25 an an DT cord-335975-m6lkrehi 2457 26 enhanced enhance VBN cord-335975-m6lkrehi 2457 27 CT CT NNP cord-335975-m6lkrehi 2457 28 - - HYPH cord-335975-m6lkrehi 2457 29 scan scan JJ cord-335975-m6lkrehi 2457 30 24 24 CD cord-335975-m6lkrehi 2457 31 h h NN cord-335975-m6lkrehi 2457 32 after after IN cord-335975-m6lkrehi 2457 33 thrombolysis thrombolysis NN cord-335975-m6lkrehi 2457 34 . . . cord-335975-m6lkrehi 2458 1 Assessement assessement NN cord-335975-m6lkrehi 2458 2 criteria criterion NNS cord-335975-m6lkrehi 2458 3 were be VBD cord-335975-m6lkrehi 2458 4 : : : cord-335975-m6lkrehi 2458 5 Qanadli Qanadli NNP cord-335975-m6lkrehi 2458 6 obstruction obstruction NN cord-335975-m6lkrehi 2458 7 index index NN cord-335975-m6lkrehi 2458 8 ; ; : cord-335975-m6lkrehi 2459 1 Signs sign NNS cord-335975-m6lkrehi 2459 2 of of IN cord-335975-m6lkrehi 2459 3 ACP ACP NNP cord-335975-m6lkrehi 2459 4 - - HYPH cord-335975-m6lkrehi 2459 5 right right JJ cord-335975-m6lkrehi 2459 6 ventricle ventricle NN cord-335975-m6lkrehi 2459 7 diameter diameter NN cord-335975-m6lkrehi 2459 8 left left JJ cord-335975-m6lkrehi 2459 9 ventricle ventricle NN cord-335975-m6lkrehi 2459 10 diameter diameter NN cord-335975-m6lkrehi 2459 11 ( ( -LRB- cord-335975-m6lkrehi 2459 12 RVD RVD NNP cord-335975-m6lkrehi 2459 13 LVD LVD NNP cord-335975-m6lkrehi 2459 14 ) ) -RRB- cord-335975-m6lkrehi 2459 15 and and CC cord-335975-m6lkrehi 2459 16 paradoxical paradoxical JJ cord-335975-m6lkrehi 2459 17 interventricular interventricular JJ cord-335975-m6lkrehi 2459 18 septum septum NN cord-335975-m6lkrehi 2459 19 ( ( -LRB- cord-335975-m6lkrehi 2459 20 IVS IVS NNP cord-335975-m6lkrehi 2459 21 ) ) -RRB- cord-335975-m6lkrehi 2459 22 . . . cord-335975-m6lkrehi 2460 1 Non non JJ cord-335975-m6lkrehi 2460 2 inclusion inclusion NN cord-335975-m6lkrehi 2460 3 criteria criterion NNS cord-335975-m6lkrehi 2460 4 were be VBD cord-335975-m6lkrehi 2460 5 : : : cord-335975-m6lkrehi 2460 6 lack lack NN cord-335975-m6lkrehi 2460 7 of of IN cord-335975-m6lkrehi 2460 8 initial initial JJ cord-335975-m6lkrehi 2460 9 or or CC cord-335975-m6lkrehi 2460 10 control control NN cord-335975-m6lkrehi 2460 11 CT CT NNP cord-335975-m6lkrehi 2460 12 - - HYPH cord-335975-m6lkrehi 2460 13 scan scan NN cord-335975-m6lkrehi 2460 14 . . . cord-335975-m6lkrehi 2461 1 Results result NNS cord-335975-m6lkrehi 2461 2 : : : cord-335975-m6lkrehi 2462 1 During during IN cord-335975-m6lkrehi 2462 2 the the DT cord-335975-m6lkrehi 2462 3 study study NN cord-335975-m6lkrehi 2462 4 period period NN cord-335975-m6lkrehi 2462 5 ( ( -LRB- cord-335975-m6lkrehi 2462 6 3 3 CD cord-335975-m6lkrehi 2462 7 years year NNS cord-335975-m6lkrehi 2462 8 and and CC cord-335975-m6lkrehi 2462 9 8 8 CD cord-335975-m6lkrehi 2462 10 months month NNS cord-335975-m6lkrehi 2462 11 ) ) -RRB- cord-335975-m6lkrehi 2462 12 we -PRON- PRP cord-335975-m6lkrehi 2462 13 admitted admit VBD cord-335975-m6lkrehi 2462 14 1790 1790 CD cord-335975-m6lkrehi 2462 15 patients patient NNS cord-335975-m6lkrehi 2462 16 from from IN cord-335975-m6lkrehi 2462 17 whom whom WP cord-335975-m6lkrehi 2462 18 98 98 CD cord-335975-m6lkrehi 2462 19 patients patient NNS cord-335975-m6lkrehi 2462 20 had have VBD cord-335975-m6lkrehi 2462 21 acute acute JJ cord-335975-m6lkrehi 2462 22 PE PE NNP cord-335975-m6lkrehi 2462 23 ( ( -LRB- cord-335975-m6lkrehi 2462 24 5.5 5.5 CD cord-335975-m6lkrehi 2462 25 % % NN cord-335975-m6lkrehi 2462 26 ) ) -RRB- cord-335975-m6lkrehi 2462 27 . . . cord-335975-m6lkrehi 2463 1 Very very RB cord-335975-m6lkrehi 2463 2 severe severe JJ cord-335975-m6lkrehi 2463 3 patients patient NNS cord-335975-m6lkrehi 2463 4 that that WDT cord-335975-m6lkrehi 2463 5 were be VBD cord-335975-m6lkrehi 2463 6 thrombolysed thrombolyse VBN cord-335975-m6lkrehi 2463 7 as as IN cord-335975-m6lkrehi 2463 8 rescue rescue NN cord-335975-m6lkrehi 2463 9 therapy therapy NN cord-335975-m6lkrehi 2463 10 without without IN cord-335975-m6lkrehi 2463 11 initial initial JJ cord-335975-m6lkrehi 2463 12 CTscan CTscan NNP cord-335975-m6lkrehi 2463 13 and and CC cord-335975-m6lkrehi 2463 14 those those DT cord-335975-m6lkrehi 2463 15 who who WP cord-335975-m6lkrehi 2463 16 died die VBD cord-335975-m6lkrehi 2463 17 before before IN cord-335975-m6lkrehi 2463 18 control control NN cord-335975-m6lkrehi 2463 19 CT CT NNP cord-335975-m6lkrehi 2463 20 - - HYPH cord-335975-m6lkrehi 2463 21 scan scan NNP cord-335975-m6lkrehi 2463 22 were be VBD cord-335975-m6lkrehi 2463 23 not not RB cord-335975-m6lkrehi 2463 24 included include VBN cord-335975-m6lkrehi 2463 25 . . . cord-335975-m6lkrehi 2464 1 We -PRON- PRP cord-335975-m6lkrehi 2464 2 enrolled enrol VBD cord-335975-m6lkrehi 2464 3 33 33 CD cord-335975-m6lkrehi 2464 4 patients patient NNS cord-335975-m6lkrehi 2464 5 - - : cord-335975-m6lkrehi 2464 6 high high JJ cord-335975-m6lkrehi 2464 7 risk risk NN cord-335975-m6lkrehi 2464 8 mortality mortality NN cord-335975-m6lkrehi 2464 9 PE PE NNP cord-335975-m6lkrehi 2464 10 ( ( -LRB- cord-335975-m6lkrehi 2464 11 n n NN cord-335975-m6lkrehi 2464 12 = = SYM cord-335975-m6lkrehi 2464 13 10 10 CD cord-335975-m6lkrehi 2464 14 , , , cord-335975-m6lkrehi 2464 15 30.3 30.3 CD cord-335975-m6lkrehi 2464 16 % % NN cord-335975-m6lkrehi 2464 17 ) ) -RRB- cord-335975-m6lkrehi 2464 18 and and CC cord-335975-m6lkrehi 2464 19 intermediate intermediate JJ cord-335975-m6lkrehi 2464 20 high high JJ cord-335975-m6lkrehi 2464 21 risk risk NN cord-335975-m6lkrehi 2464 22 PE PE NNP cord-335975-m6lkrehi 2464 23 ( ( -LRB- cord-335975-m6lkrehi 2464 24 n n NN cord-335975-m6lkrehi 2464 25 = = SYM cord-335975-m6lkrehi 2464 26 23 23 CD cord-335975-m6lkrehi 2464 27 , , , cord-335975-m6lkrehi 2464 28 69.7 69.7 CD cord-335975-m6lkrehi 2464 29 % % NN cord-335975-m6lkrehi 2464 30 ) ) -RRB- cord-335975-m6lkrehi 2464 31 . . . cord-335975-m6lkrehi 2465 1 Mean mean JJ cord-335975-m6lkrehi 2465 2 age age NN cord-335975-m6lkrehi 2465 3 was be VBD cord-335975-m6lkrehi 2465 4 60 60 CD cord-335975-m6lkrehi 2465 5 years year NNS cord-335975-m6lkrehi 2465 6 and and CC cord-335975-m6lkrehi 2465 7 sex sex NN cord-335975-m6lkrehi 2465 8 - - HYPH cord-335975-m6lkrehi 2465 9 ratio ratio NN cord-335975-m6lkrehi 2465 10 was be VBD cord-335975-m6lkrehi 2465 11 1.06 1.06 CD cord-335975-m6lkrehi 2465 12 . . . cord-335975-m6lkrehi 2466 1 At at IN cord-335975-m6lkrehi 2466 2 admission admission NN cord-335975-m6lkrehi 2466 3 , , , cord-335975-m6lkrehi 2466 4 mean mean JJ cord-335975-m6lkrehi 2466 5 severity severity NN cord-335975-m6lkrehi 2466 6 scores score NNS cord-335975-m6lkrehi 2466 7 were be VBD cord-335975-m6lkrehi 2466 8 22.1 22.1 CD cord-335975-m6lkrehi 2466 9 ± ± CD cord-335975-m6lkrehi 2466 10 9.4 9.4 CD cord-335975-m6lkrehi 2466 11 for for IN cord-335975-m6lkrehi 2466 12 SAPS SAPS NNP cord-335975-m6lkrehi 2466 13 II II NNP cord-335975-m6lkrehi 2466 14 and and CC cord-335975-m6lkrehi 2466 15 7.6 7.6 CD cord-335975-m6lkrehi 2466 16 ± ± CD cord-335975-m6lkrehi 2466 17 4.2 4.2 CD cord-335975-m6lkrehi 2466 18 for for IN cord-335975-m6lkrehi 2466 19 APACHE APACHE NNP cord-335975-m6lkrehi 2466 20 II II NNP cord-335975-m6lkrehi 2466 21 . . . cord-335975-m6lkrehi 2467 1 Evolution evolution NN cord-335975-m6lkrehi 2467 2 criteria criterion NNS cord-335975-m6lkrehi 2467 3 are be VBP cord-335975-m6lkrehi 2467 4 listed list VBN cord-335975-m6lkrehi 2467 5 in in IN cord-335975-m6lkrehi 2467 6 Table Table NNP cord-335975-m6lkrehi 2467 7 1 1 CD cord-335975-m6lkrehi 2467 8 . . . cord-335975-m6lkrehi 2468 1 Conclusion conclusion NN cord-335975-m6lkrehi 2468 2 : : : cord-335975-m6lkrehi 2469 1 Control Control NNP cord-335975-m6lkrehi 2469 2 CT CT NNP cord-335975-m6lkrehi 2469 3 - - HYPH cord-335975-m6lkrehi 2469 4 scan scan NN cord-335975-m6lkrehi 2469 5 is be VBZ cord-335975-m6lkrehi 2469 6 highly highly RB cord-335975-m6lkrehi 2469 7 useful useful JJ cord-335975-m6lkrehi 2469 8 24 24 CD cord-335975-m6lkrehi 2469 9 h h NN cord-335975-m6lkrehi 2469 10 after after IN cord-335975-m6lkrehi 2469 11 thrombolysis thrombolysis NN cord-335975-m6lkrehi 2469 12 . . . cord-335975-m6lkrehi 2470 1 It -PRON- PRP cord-335975-m6lkrehi 2470 2 allows allow VBZ cord-335975-m6lkrehi 2470 3 evaluation evaluation NN cord-335975-m6lkrehi 2470 4 of of IN cord-335975-m6lkrehi 2470 5 response response NN cord-335975-m6lkrehi 2470 6 to to IN cord-335975-m6lkrehi 2470 7 pharmacological pharmacological JJ cord-335975-m6lkrehi 2470 8 thrombolysis thrombolysis NN cord-335975-m6lkrehi 2470 9 of of IN cord-335975-m6lkrehi 2470 10 acute acute JJ cord-335975-m6lkrehi 2470 11 PE PE NNP cord-335975-m6lkrehi 2470 12 and and CC cord-335975-m6lkrehi 2470 13 shows show VBZ cord-335975-m6lkrehi 2470 14 significative significative JJ cord-335975-m6lkrehi 2470 15 resolution resolution NN cord-335975-m6lkrehi 2470 16 of of IN cord-335975-m6lkrehi 2470 17 arterial arterial JJ cord-335975-m6lkrehi 2470 18 obstruction obstruction NN cord-335975-m6lkrehi 2470 19 degree degree NN cord-335975-m6lkrehi 2470 20 and and CC cord-335975-m6lkrehi 2470 21 signs sign NNS cord-335975-m6lkrehi 2470 22 of of IN cord-335975-m6lkrehi 2470 23 ACP ACP NNP cord-335975-m6lkrehi 2470 24 . . . cord-335975-m6lkrehi 2471 1 In in IN cord-335975-m6lkrehi 2471 2 December December NNP cord-335975-m6lkrehi 2471 3 2016 2016 CD cord-335975-m6lkrehi 2471 4 , , , cord-335975-m6lkrehi 2471 5 after after IN cord-335975-m6lkrehi 2471 6 cancellation cancellation NN cord-335975-m6lkrehi 2471 7 of of IN cord-335975-m6lkrehi 2471 8 the the DT cord-335975-m6lkrehi 2471 9 budget budget NN cord-335975-m6lkrehi 2471 10 for for IN cord-335975-m6lkrehi 2471 11 a a DT cord-335975-m6lkrehi 2471 12 Christmas Christmas NNP cord-335975-m6lkrehi 2471 13 tree tree NN cord-335975-m6lkrehi 2471 14 , , , cord-335975-m6lkrehi 2471 15 the the DT cord-335975-m6lkrehi 2471 16 nurses nurse NNS cord-335975-m6lkrehi 2471 17 and and CC cord-335975-m6lkrehi 2471 18 caregivers caregiver NNS cord-335975-m6lkrehi 2471 19 of of IN cord-335975-m6lkrehi 2471 20 the the DT cord-335975-m6lkrehi 2471 21 night night NN cord-335975-m6lkrehi 2471 22 team team NN cord-335975-m6lkrehi 2471 23 spontaneously spontaneously RB cord-335975-m6lkrehi 2471 24 made make VBD cord-335975-m6lkrehi 2471 25 and and CC cord-335975-m6lkrehi 2471 26 hung hang VBD cord-335975-m6lkrehi 2471 27 Christmas Christmas NNP cord-335975-m6lkrehi 2471 28 decorations decoration NNS cord-335975-m6lkrehi 2471 29 in in IN cord-335975-m6lkrehi 2471 30 our -PRON- PRP$ cord-335975-m6lkrehi 2471 31 Intensive Intensive NNP cord-335975-m6lkrehi 2471 32 Care Care NNP cord-335975-m6lkrehi 2471 33 Unit Unit NNP cord-335975-m6lkrehi 2471 34 to to TO cord-335975-m6lkrehi 2471 35 make make VB cord-335975-m6lkrehi 2471 36 patients patient NNS cord-335975-m6lkrehi 2471 37 and and CC cord-335975-m6lkrehi 2471 38 their -PRON- PRP$ cord-335975-m6lkrehi 2471 39 families family NNS cord-335975-m6lkrehi 2471 40 feel feel VBP cord-335975-m6lkrehi 2471 41 better well JJR cord-335975-m6lkrehi 2471 42 . . . cord-335975-m6lkrehi 2472 1 The the DT cord-335975-m6lkrehi 2472 2 context context NN cord-335975-m6lkrehi 2472 3 was be VBD cord-335975-m6lkrehi 2472 4 difficult difficult JJ cord-335975-m6lkrehi 2472 5 with with IN cord-335975-m6lkrehi 2472 6 controversies controversy NNS cord-335975-m6lkrehi 2472 7 around around IN cord-335975-m6lkrehi 2472 8 secularity secularity NN cord-335975-m6lkrehi 2472 9 . . . cord-335975-m6lkrehi 2473 1 The the DT cord-335975-m6lkrehi 2473 2 town town NN cord-335975-m6lkrehi 2473 3 of of IN cord-335975-m6lkrehi 2473 4 Paray Paray NNP cord-335975-m6lkrehi 2473 5 Le Le NNP cord-335975-m6lkrehi 2473 6 Monial Monial NNP cord-335975-m6lkrehi 2473 7 had have VBD cord-335975-m6lkrehi 2473 8 been be VBN cord-335975-m6lkrehi 2473 9 forced force VBN cord-335975-m6lkrehi 2473 10 to to TO cord-335975-m6lkrehi 2473 11 remove remove VB cord-335975-m6lkrehi 2473 12 a a DT cord-335975-m6lkrehi 2473 13 Nativity Nativity NNP cord-335975-m6lkrehi 2473 14 scene scene NN cord-335975-m6lkrehi 2473 15 and and CC cord-335975-m6lkrehi 2473 16 the the DT cord-335975-m6lkrehi 2473 17 city city NN cord-335975-m6lkrehi 2473 18 of of IN cord-335975-m6lkrehi 2473 19 Melun Melun NNP cord-335975-m6lkrehi 2473 20 had have VBD cord-335975-m6lkrehi 2473 21 been be VBN cord-335975-m6lkrehi 2473 22 criticized criticize VBN cord-335975-m6lkrehi 2473 23 for for IN cord-335975-m6lkrehi 2473 24 setting set VBG cord-335975-m6lkrehi 2473 25 one one CD cord-335975-m6lkrehi 2473 26 up up RP cord-335975-m6lkrehi 2473 27 . . . cord-335975-m6lkrehi 2474 1 So so RB cord-335975-m6lkrehi 2474 2 we -PRON- PRP cord-335975-m6lkrehi 2474 3 found find VBD cord-335975-m6lkrehi 2474 4 it -PRON- PRP cord-335975-m6lkrehi 2474 5 important important JJ cord-335975-m6lkrehi 2474 6 to to TO cord-335975-m6lkrehi 2474 7 assess assess VB cord-335975-m6lkrehi 2474 8 the the DT cord-335975-m6lkrehi 2474 9 perception perception NN cord-335975-m6lkrehi 2474 10 of of IN cord-335975-m6lkrehi 2474 11 the the DT cord-335975-m6lkrehi 2474 12 approach approach NN cord-335975-m6lkrehi 2474 13 by by IN cord-335975-m6lkrehi 2474 14 patients patient NNS cord-335975-m6lkrehi 2474 15 and and CC cord-335975-m6lkrehi 2474 16 relatives relative NNS cord-335975-m6lkrehi 2474 17 . . . cord-335975-m6lkrehi 2475 1 Patients patient NNS cord-335975-m6lkrehi 2475 2 and and CC cord-335975-m6lkrehi 2475 3 methods method NNS cord-335975-m6lkrehi 2475 4 : : : cord-335975-m6lkrehi 2475 5 Decorations decoration NNS cord-335975-m6lkrehi 2475 6 -Hand -hand JJ cord-335975-m6lkrehi 2475 7 - - HYPH cord-335975-m6lkrehi 2475 8 colored colored JJ cord-335975-m6lkrehi 2475 9 patterns pattern NNS cord-335975-m6lkrehi 2475 10 about about IN cord-335975-m6lkrehi 2475 11 Christmas Christmas NNP cord-335975-m6lkrehi 2475 12 theme theme NN cord-335975-m6lkrehi 2475 13 printed print VBN cord-335975-m6lkrehi 2475 14 on on IN cord-335975-m6lkrehi 2475 15 A4 A4 NNP cord-335975-m6lkrehi 2475 16 paper paper NN cord-335975-m6lkrehi 2475 17 Decorations decoration NNS cord-335975-m6lkrehi 2475 18 brought bring VBN cord-335975-m6lkrehi 2475 19 by by IN cord-335975-m6lkrehi 2475 20 the the DT cord-335975-m6lkrehi 2475 21 staff staff NN cord-335975-m6lkrehi 2475 22 or or CC cord-335975-m6lkrehi 2475 23 already already RB cord-335975-m6lkrehi 2475 24 possessed possess VBN cord-335975-m6lkrehi 2475 25 by by IN cord-335975-m6lkrehi 2475 26 the the DT cord-335975-m6lkrehi 2475 27 unit unit NN cord-335975-m6lkrehi 2475 28 - - : cord-335975-m6lkrehi 2475 29 Christmas Christmas NNP cord-335975-m6lkrehi 2475 30 balls ball NNS cord-335975-m6lkrehi 2475 31 , , , cord-335975-m6lkrehi 2475 32 garlands garland NNS cord-335975-m6lkrehi 2475 33 , , , cord-335975-m6lkrehi 2475 34 silver silver NN cord-335975-m6lkrehi 2475 35 starDecorations stardecoration NNS cord-335975-m6lkrehi 2475 36 made make VBN cord-335975-m6lkrehi 2475 37 with with IN cord-335975-m6lkrehi 2475 38 service service NN cord-335975-m6lkrehi 2475 39 equipment equipment NN cord-335975-m6lkrehi 2475 40 - - : cord-335975-m6lkrehi 2475 41 Christmas Christmas NNP cord-335975-m6lkrehi 2475 42 tree tree NN cord-335975-m6lkrehi 2475 43 consisting consist VBG cord-335975-m6lkrehi 2475 44 of of IN cord-335975-m6lkrehi 2475 45 inflated inflated JJ cord-335975-m6lkrehi 2475 46 non non JJ cord-335975-m6lkrehi 2475 47 - - JJ cord-335975-m6lkrehi 2475 48 sterile sterile JJ cord-335975-m6lkrehi 2475 49 gloves glove NNS cord-335975-m6lkrehi 2475 50 , , , cord-335975-m6lkrehi 2475 51 cardboard cardboard NN cord-335975-m6lkrehi 2475 52 , , , cord-335975-m6lkrehi 2475 53 figurative figurative JJ cord-335975-m6lkrehi 2475 54 Nativity nativity NN cord-335975-m6lkrehi 2475 55 scene scene NN cord-335975-m6lkrehi 2475 56 without without IN cord-335975-m6lkrehi 2475 57 a a DT cord-335975-m6lkrehi 2475 58 recognizable recognizable JJ cord-335975-m6lkrehi 2475 59 figure figure NN cord-335975-m6lkrehi 2475 60 in in IN cord-335975-m6lkrehi 2475 61 a a DT cord-335975-m6lkrehi 2475 62 cardboard cardboard NN cord-335975-m6lkrehi 2475 63 box box NN cord-335975-m6lkrehi 2475 64 with with IN cord-335975-m6lkrehi 2475 65 cotton cotton NN cord-335975-m6lkrehi 2475 66 , , , cord-335975-m6lkrehi 2475 67 bed bed NN cord-335975-m6lkrehi 2475 68 sheet sheet NN cord-335975-m6lkrehi 2475 69 to to TO cord-335975-m6lkrehi 2475 70 simulate simulate VB cord-335975-m6lkrehi 2475 71 snow snow NN cord-335975-m6lkrehi 2475 72 . . . cord-335975-m6lkrehi 2476 1 Evaluation evaluation NN cord-335975-m6lkrehi 2477 1 -All -all WDT cord-335975-m6lkrehi 2477 2 visitors visitor NNS cord-335975-m6lkrehi 2477 3 and and CC cord-335975-m6lkrehi 2477 4 conscious conscious JJ cord-335975-m6lkrehi 2477 5 patients patient NNS cord-335975-m6lkrehi 2477 6 received receive VBD cord-335975-m6lkrehi 2477 7 an an DT cord-335975-m6lkrehi 2477 8 anonymous anonymous JJ cord-335975-m6lkrehi 2477 9 single single JJ cord-335975-m6lkrehi 2477 10 choice choice NN cord-335975-m6lkrehi 2477 11 questionnaire questionnaire NN cord-335975-m6lkrehi 2477 12 with with IN cord-335975-m6lkrehi 2477 13 numerical numerical JJ cord-335975-m6lkrehi 2477 14 scale scale NN cord-335975-m6lkrehi 2477 15 and and CC cord-335975-m6lkrehi 2477 16 free free JJ cord-335975-m6lkrehi 2477 17 fields field NNS cord-335975-m6lkrehi 2477 18 from from IN cord-335975-m6lkrehi 2477 19 December December NNP cord-335975-m6lkrehi 2477 20 15th 15th NN cord-335975-m6lkrehi 2477 21 to to IN cord-335975-m6lkrehi 2477 22 December December NNP cord-335975-m6lkrehi 2477 23 31st 31st NN cord-335975-m6lkrehi 2477 24 , , , cord-335975-m6lkrehi 2477 25 2016 2016 CD cord-335975-m6lkrehi 2477 26 . . . cord-335975-m6lkrehi 2478 1 Results result NNS cord-335975-m6lkrehi 2478 2 : : : cord-335975-m6lkrehi 2479 1 59 59 CD cord-335975-m6lkrehi 2479 2 answers answer NNS cord-335975-m6lkrehi 2479 3 were be VBD cord-335975-m6lkrehi 2479 4 received receive VBN cord-335975-m6lkrehi 2479 5 , , , cord-335975-m6lkrehi 2479 6 including- including- XX cord-335975-m6lkrehi 2480 1 No no DT cord-335975-m6lkrehi 2480 2 negative negative JJ cord-335975-m6lkrehi 2480 3 opinion opinion NN cord-335975-m6lkrehi 2480 4 . . . cord-335975-m6lkrehi 2481 1 1 1 CD cord-335975-m6lkrehi 2481 2 neutral neutral JJ cord-335975-m6lkrehi 2481 3 answer answer NN cord-335975-m6lkrehi 2481 4 by by IN cord-335975-m6lkrehi 2481 5 a a DT cord-335975-m6lkrehi 2481 6 person person NN cord-335975-m6lkrehi 2481 7 who who WP cord-335975-m6lkrehi 2481 8 had have VBD cord-335975-m6lkrehi 2481 9 not not RB cord-335975-m6lkrehi 2481 10 noticed notice VBN cord-335975-m6lkrehi 2481 11 the the DT cord-335975-m6lkrehi 2481 12 decorations decoration NNS cord-335975-m6lkrehi 2481 13 . . . cord-335975-m6lkrehi 2482 1 54 54 CD cord-335975-m6lkrehi 2482 2 positive positive JJ cord-335975-m6lkrehi 2482 3 or or CC cord-335975-m6lkrehi 2482 4 extremely extremely RB cord-335975-m6lkrehi 2482 5 positive positive JJ cord-335975-m6lkrehi 2482 6 opinions opinion NNS cord-335975-m6lkrehi 2482 7 . . . cord-335975-m6lkrehi 2483 1 No no DT cord-335975-m6lkrehi 2483 2 answer answer NN cord-335975-m6lkrehi 2483 3 without without IN cord-335975-m6lkrehi 2483 4 data datum NNS cord-335975-m6lkrehi 2483 5 . . . cord-335975-m6lkrehi 2484 1 The the DT cord-335975-m6lkrehi 2484 2 comments comment NNS cord-335975-m6lkrehi 2484 3 pointed point VBD cord-335975-m6lkrehi 2484 4 out out RP cord-335975-m6lkrehi 2484 5 the the DT cord-335975-m6lkrehi 2484 6 originality originality NN cord-335975-m6lkrehi 2484 7 , , , cord-335975-m6lkrehi 2484 8 the the DT cord-335975-m6lkrehi 2484 9 good good JJ cord-335975-m6lkrehi 2484 10 idea idea NN cord-335975-m6lkrehi 2484 11 , , , cord-335975-m6lkrehi 2484 12 the the DT cord-335975-m6lkrehi 2484 13 warm warm JJ cord-335975-m6lkrehi 2484 14 comforting comforting JJ cord-335975-m6lkrehi 2484 15 side side NN cord-335975-m6lkrehi 2484 16 . . . cord-335975-m6lkrehi 2485 1 Some some DT cord-335975-m6lkrehi 2485 2 asked ask VBD cord-335975-m6lkrehi 2485 3 for for IN cord-335975-m6lkrehi 2485 4 more more JJR cord-335975-m6lkrehi 2485 5 decorations decoration NNS cord-335975-m6lkrehi 2485 6 . . . cord-335975-m6lkrehi 2486 1 Others other NNS cord-335975-m6lkrehi 2486 2 found find VBD cord-335975-m6lkrehi 2486 3 them -PRON- PRP cord-335975-m6lkrehi 2486 4 sober sober JJ cord-335975-m6lkrehi 2486 5 . . . cord-335975-m6lkrehi 2486 6 _SP cord-335975-m6lkrehi 2487 1 The the DT cord-335975-m6lkrehi 2487 2 results result NNS cord-335975-m6lkrehi 2487 3 show show VBP cord-335975-m6lkrehi 2487 4 the the DT cord-335975-m6lkrehi 2487 5 good good JJ cord-335975-m6lkrehi 2487 6 perception perception NN cord-335975-m6lkrehi 2487 7 of of IN cord-335975-m6lkrehi 2487 8 the the DT cord-335975-m6lkrehi 2487 9 spontaneous spontaneous JJ cord-335975-m6lkrehi 2487 10 action action NN cord-335975-m6lkrehi 2487 11 by by IN cord-335975-m6lkrehi 2487 12 the the DT cord-335975-m6lkrehi 2487 13 patients patient NNS cord-335975-m6lkrehi 2487 14 and and CC cord-335975-m6lkrehi 2487 15 their -PRON- PRP$ cord-335975-m6lkrehi 2487 16 relatives relative NNS cord-335975-m6lkrehi 2487 17 . . . cord-335975-m6lkrehi 2488 1 There there EX cord-335975-m6lkrehi 2488 2 was be VBD cord-335975-m6lkrehi 2488 3 no no DT cord-335975-m6lkrehi 2488 4 negative negative JJ cord-335975-m6lkrehi 2488 5 response response NN cord-335975-m6lkrehi 2488 6 , , , cord-335975-m6lkrehi 2488 7 particularly particularly RB cord-335975-m6lkrehi 2488 8 offend offend VB cord-335975-m6lkrehi 2488 9 persons person NNS cord-335975-m6lkrehi 2488 10 . . . cord-335975-m6lkrehi 2489 1 However however RB cord-335975-m6lkrehi 2489 2 , , , cord-335975-m6lkrehi 2489 3 it -PRON- PRP cord-335975-m6lkrehi 2489 4 is be VBZ cord-335975-m6lkrehi 2489 5 possible possible JJ cord-335975-m6lkrehi 2489 6 that that IN cord-335975-m6lkrehi 2489 7 relatives relative NNS cord-335975-m6lkrehi 2489 8 or or CC cord-335975-m6lkrehi 2489 9 patients patient NNS cord-335975-m6lkrehi 2489 10 with with IN cord-335975-m6lkrehi 2489 11 negative negative JJ cord-335975-m6lkrehi 2489 12 opinions opinion NNS cord-335975-m6lkrehi 2489 13 did do VBD cord-335975-m6lkrehi 2489 14 not not RB cord-335975-m6lkrehi 2489 15 dare dare VB cord-335975-m6lkrehi 2489 16 to to TO cord-335975-m6lkrehi 2489 17 express express VB cord-335975-m6lkrehi 2489 18 themselves -PRON- PRP cord-335975-m6lkrehi 2489 19 . . . cord-335975-m6lkrehi 2490 1 The the DT cord-335975-m6lkrehi 2490 2 initiative initiative NN cord-335975-m6lkrehi 2490 3 demonstrated demonstrate VBD cord-335975-m6lkrehi 2490 4 a a DT cord-335975-m6lkrehi 2490 5 good good JJ cord-335975-m6lkrehi 2490 6 cohesion cohesion NN cord-335975-m6lkrehi 2490 7 of of IN cord-335975-m6lkrehi 2490 8 the the DT cord-335975-m6lkrehi 2490 9 night night NN cord-335975-m6lkrehi 2490 10 paramedical paramedical JJ cord-335975-m6lkrehi 2490 11 team team NN cord-335975-m6lkrehi 2490 12 , , , cord-335975-m6lkrehi 2490 13 encouraging encourage VBG cord-335975-m6lkrehi 2490 14 the the DT cord-335975-m6lkrehi 2490 15 interns intern NNS cord-335975-m6lkrehi 2490 16 and and CC cord-335975-m6lkrehi 2490 17 the the DT cord-335975-m6lkrehi 2490 18 day day NN cord-335975-m6lkrehi 2490 19 teams team NNS cord-335975-m6lkrehi 2490 20 to to TO cord-335975-m6lkrehi 2490 21 take take VB cord-335975-m6lkrehi 2490 22 part part NN cord-335975-m6lkrehi 2490 23 in in IN cord-335975-m6lkrehi 2490 24 the the DT cord-335975-m6lkrehi 2490 25 coloring coloring NN cord-335975-m6lkrehi 2490 26 of of IN cord-335975-m6lkrehi 2490 27 the the DT cord-335975-m6lkrehi 2490 28 decorations decoration NNS cord-335975-m6lkrehi 2490 29 . . . cord-335975-m6lkrehi 2491 1 The the DT cord-335975-m6lkrehi 2491 2 initiative initiative NN cord-335975-m6lkrehi 2491 3 was be VBD cord-335975-m6lkrehi 2491 4 initially initially RB cord-335975-m6lkrehi 2491 5 aimed aim VBN cord-335975-m6lkrehi 2491 6 at at IN cord-335975-m6lkrehi 2491 7 the the DT cord-335975-m6lkrehi 2491 8 wellbeing wellbeing NN cord-335975-m6lkrehi 2491 9 of of IN cord-335975-m6lkrehi 2491 10 the the DT cord-335975-m6lkrehi 2491 11 patients patient NNS cord-335975-m6lkrehi 2491 12 and and CC cord-335975-m6lkrehi 2491 13 their -PRON- PRP$ cord-335975-m6lkrehi 2491 14 relatives relative NNS cord-335975-m6lkrehi 2491 15 . . . cord-335975-m6lkrehi 2492 1 However however RB cord-335975-m6lkrehi 2492 2 it -PRON- PRP cord-335975-m6lkrehi 2492 3 has have VBZ cord-335975-m6lkrehi 2492 4 enabled enable VBN cord-335975-m6lkrehi 2492 5 an an DT cord-335975-m6lkrehi 2492 6 activity activity NN cord-335975-m6lkrehi 2492 7 similar similar JJ cord-335975-m6lkrehi 2492 8 to to IN cord-335975-m6lkrehi 2492 9 preventing prevent VBG cord-335975-m6lkrehi 2492 10 psychosocial psychosocial JJ cord-335975-m6lkrehi 2492 11 risks risk NNS cord-335975-m6lkrehi 2492 12 among among IN cord-335975-m6lkrehi 2492 13 the the DT cord-335975-m6lkrehi 2492 14 healthcare healthcare NN cord-335975-m6lkrehi 2492 15 team team NN cord-335975-m6lkrehi 2492 16 , , , cord-335975-m6lkrehi 2492 17 allowing allow VBG cord-335975-m6lkrehi 2492 18 them -PRON- PRP cord-335975-m6lkrehi 2492 19 to to TO cord-335975-m6lkrehi 2492 20 adopt adopt VB cord-335975-m6lkrehi 2492 21 a a DT cord-335975-m6lkrehi 2492 22 positive positive JJ cord-335975-m6lkrehi 2492 23 attitude attitude NN cord-335975-m6lkrehi 2492 24 in in IN cord-335975-m6lkrehi 2492 25 their -PRON- PRP$ cord-335975-m6lkrehi 2492 26 approach approach NN cord-335975-m6lkrehi 2492 27 to to TO cord-335975-m6lkrehi 2492 28 care care VB cord-335975-m6lkrehi 2492 29 . . . cord-335975-m6lkrehi 2493 1 In in IN cord-335975-m6lkrehi 2493 2 addition addition NN cord-335975-m6lkrehi 2493 3 , , , cord-335975-m6lkrehi 2493 4 no no DT cord-335975-m6lkrehi 2493 5 significant significant JJ cord-335975-m6lkrehi 2493 6 costs cost NNS cord-335975-m6lkrehi 2493 7 were be VBD cord-335975-m6lkrehi 2493 8 incurred incur VBN cord-335975-m6lkrehi 2493 9 thanks thank NNS cord-335975-m6lkrehi 2493 10 to to IN cord-335975-m6lkrehi 2493 11 the the DT cord-335975-m6lkrehi 2493 12 use use NN cord-335975-m6lkrehi 2493 13 of of IN cord-335975-m6lkrehi 2493 14 cheap cheap JJ cord-335975-m6lkrehi 2493 15 materials material NNS cord-335975-m6lkrehi 2493 16 , , , cord-335975-m6lkrehi 2493 17 mainly mainly RB cord-335975-m6lkrehi 2493 18 recycled recycle VBN cord-335975-m6lkrehi 2493 19 cardboard cardboard NN cord-335975-m6lkrehi 2493 20 and and CC cord-335975-m6lkrehi 2493 21 standard standard JJ cord-335975-m6lkrehi 2493 22 quality quality NN cord-335975-m6lkrehi 2493 23 white white JJ cord-335975-m6lkrehi 2493 24 paper paper NN cord-335975-m6lkrehi 2493 25 . . . cord-335975-m6lkrehi 2494 1 The the DT cord-335975-m6lkrehi 2494 2 spontaneous spontaneous JJ cord-335975-m6lkrehi 2494 3 decoration decoration NN cord-335975-m6lkrehi 2494 4 of of IN cord-335975-m6lkrehi 2494 5 our -PRON- PRP$ cord-335975-m6lkrehi 2494 6 Intensive Intensive NNP cord-335975-m6lkrehi 2494 7 Care Care NNP cord-335975-m6lkrehi 2494 8 Unit Unit NNP cord-335975-m6lkrehi 2494 9 by by IN cord-335975-m6lkrehi 2494 10 the the DT cord-335975-m6lkrehi 2494 11 night night NN cord-335975-m6lkrehi 2494 12 care care NN cord-335975-m6lkrehi 2494 13 team team NN cord-335975-m6lkrehi 2494 14 was be VBD cord-335975-m6lkrehi 2494 15 very very RB cord-335975-m6lkrehi 2494 16 well well RB cord-335975-m6lkrehi 2494 17 received receive VBN cord-335975-m6lkrehi 2494 18 by by IN cord-335975-m6lkrehi 2494 19 the the DT cord-335975-m6lkrehi 2494 20 patients patient NNS cord-335975-m6lkrehi 2494 21 , , , cord-335975-m6lkrehi 2494 22 their -PRON- PRP$ cord-335975-m6lkrehi 2494 23 families family NNS cord-335975-m6lkrehi 2494 24 and and CC cord-335975-m6lkrehi 2494 25 their -PRON- PRP$ cord-335975-m6lkrehi 2494 26 relatives relative NNS cord-335975-m6lkrehi 2494 27 . . . cord-335975-m6lkrehi 2495 1 The the DT cord-335975-m6lkrehi 2495 2 initiative initiative NN cord-335975-m6lkrehi 2495 3 also also RB cord-335975-m6lkrehi 2495 4 made make VBD cord-335975-m6lkrehi 2495 5 possible possible JJ cord-335975-m6lkrehi 2495 6 to to TO cord-335975-m6lkrehi 2495 7 enhance enhance VB cord-335975-m6lkrehi 2495 8 team team NN cord-335975-m6lkrehi 2495 9 cohesion cohesion NN cord-335975-m6lkrehi 2495 10 and and CC cord-335975-m6lkrehi 2495 11 to to TO cord-335975-m6lkrehi 2495 12 value value VB cord-335975-m6lkrehi 2495 13 it -PRON- PRP cord-335975-m6lkrehi 2495 14 . . . cord-335975-m6lkrehi 2496 1 The the DT cord-335975-m6lkrehi 2496 2 associated associated JJ cord-335975-m6lkrehi 2496 3 costs cost NNS cord-335975-m6lkrehi 2496 4 were be VBD cord-335975-m6lkrehi 2496 5 negligible negligible JJ cord-335975-m6lkrehi 2496 6 . . . cord-335975-m6lkrehi 2497 1 ventricular ventricular JJ cord-335975-m6lkrehi 2497 2 contractions contraction NNS cord-335975-m6lkrehi 2497 3 . . . cord-335975-m6lkrehi 2498 1 BP BP NNP cord-335975-m6lkrehi 2498 2 monitoring monitoring NN cord-335975-m6lkrehi 2498 3 revealed reveal VBD cord-335975-m6lkrehi 2498 4 a a DT cord-335975-m6lkrehi 2498 5 greater great JJR cord-335975-m6lkrehi 2498 6 diastolic diastolic JJ cord-335975-m6lkrehi 2498 7 BP BP NNP cord-335975-m6lkrehi 2498 8 throughout throughout IN cord-335975-m6lkrehi 2498 9 24 24 CD cord-335975-m6lkrehi 2498 10 h h NN cord-335975-m6lkrehi 2498 11 as as RB cord-335975-m6lkrehi 2498 12 well well RB cord-335975-m6lkrehi 2498 13 as as IN cord-335975-m6lkrehi 2498 14 during during IN cord-335975-m6lkrehi 2498 15 night night NN cord-335975-m6lkrehi 2498 16 - - HYPH cord-335975-m6lkrehi 2498 17 time time NN cord-335975-m6lkrehi 2498 18 . . . cord-335975-m6lkrehi 2499 1 Systolic systolic JJ cord-335975-m6lkrehi 2499 2 BP BP NNP cord-335975-m6lkrehi 2499 3 higher high JJR cord-335975-m6lkrehi 2499 4 than than IN cord-335975-m6lkrehi 2499 5 125 125 CD cord-335975-m6lkrehi 2499 6 mmHg mmHg NNS cord-335975-m6lkrehi 2499 7 during during IN cord-335975-m6lkrehi 2499 8 sleep sleep NN cord-335975-m6lkrehi 2499 9 time time NN cord-335975-m6lkrehi 2499 10 was be VBD cord-335975-m6lkrehi 2499 11 observed observe VBN cord-335975-m6lkrehi 2499 12 in in IN cord-335975-m6lkrehi 2499 13 55 55 CD cord-335975-m6lkrehi 2499 14 % % NN cord-335975-m6lkrehi 2499 15 of of IN cord-335975-m6lkrehi 2499 16 participants participant NNS cord-335975-m6lkrehi 2499 17 . . . cord-335975-m6lkrehi 2500 1 The the DT cord-335975-m6lkrehi 2500 2 frequency frequency NN cord-335975-m6lkrehi 2500 3 of of IN cord-335975-m6lkrehi 2500 4 arrhythmias arrhythmia NNS cord-335975-m6lkrehi 2500 5 and and CC cord-335975-m6lkrehi 2500 6 blood blood NN cord-335975-m6lkrehi 2500 7 pressure pressure NN cord-335975-m6lkrehi 2500 8 variability variability NN cord-335975-m6lkrehi 2500 9 are be VBP cord-335975-m6lkrehi 2500 10 correlated correlate VBN cord-335975-m6lkrehi 2500 11 with with IN cord-335975-m6lkrehi 2500 12 the the DT cord-335975-m6lkrehi 2500 13 increase increase NN cord-335975-m6lkrehi 2500 14 in in IN cord-335975-m6lkrehi 2500 15 work work NN cord-335975-m6lkrehi 2500 16 stress stress NN cord-335975-m6lkrehi 2500 17 and and CC cord-335975-m6lkrehi 2500 18 conflicts conflict NNS cord-335975-m6lkrehi 2500 19 . . . cord-335975-m6lkrehi 2501 1 Conclusion conclusion NN cord-335975-m6lkrehi 2501 2 : : : cord-335975-m6lkrehi 2502 1 Our -PRON- PRP$ cord-335975-m6lkrehi 2502 2 results result NNS cord-335975-m6lkrehi 2502 3 highlight highlight VBP cord-335975-m6lkrehi 2502 4 the the DT cord-335975-m6lkrehi 2502 5 extent extent NN cord-335975-m6lkrehi 2502 6 incidence incidence NN cord-335975-m6lkrehi 2502 7 of of IN cord-335975-m6lkrehi 2502 8 arrhythmia arrhythmia NN cord-335975-m6lkrehi 2502 9 and and CC cord-335975-m6lkrehi 2502 10 blood blood NN cord-335975-m6lkrehi 2502 11 pressure pressure NN cord-335975-m6lkrehi 2502 12 variability variability NN cord-335975-m6lkrehi 2502 13 during during IN cord-335975-m6lkrehi 2502 14 intensive intensive JJ cord-335975-m6lkrehi 2502 15 care care NN cord-335975-m6lkrehi 2502 16 unit unit NN cord-335975-m6lkrehi 2502 17 night night NN cord-335975-m6lkrehi 2502 18 's 's POS cord-335975-m6lkrehi 2502 19 shift shift NN cord-335975-m6lkrehi 2502 20 probably probably RB cord-335975-m6lkrehi 2502 21 due due IN cord-335975-m6lkrehi 2502 22 to to IN cord-335975-m6lkrehi 2502 23 the the DT cord-335975-m6lkrehi 2502 24 increased increase VBN cord-335975-m6lkrehi 2502 25 neuroendocrine neuroendocrine JJ cord-335975-m6lkrehi 2502 26 stress stress NN cord-335975-m6lkrehi 2502 27 response response NN cord-335975-m6lkrehi 2502 28 . . . cord-335975-m6lkrehi 2503 1 ( ( -LRB- cord-335975-m6lkrehi 2503 2 55 55 CD cord-335975-m6lkrehi 2503 3 % % NN cord-335975-m6lkrehi 2503 4 ) ) -RRB- cord-335975-m6lkrehi 2503 5 and and CC cord-335975-m6lkrehi 2503 6 QRS qrs NN cord-335975-m6lkrehi 2503 7 enlargement enlargement NN cord-335975-m6lkrehi 2503 8 ( ( -LRB- cord-335975-m6lkrehi 2503 9 50 50 CD cord-335975-m6lkrehi 2503 10 % % NN cord-335975-m6lkrehi 2503 11 ) ) -RRB- cord-335975-m6lkrehi 2503 12 . . . cord-335975-m6lkrehi 2504 1 AMI AMI NNP cord-335975-m6lkrehi 2504 2 was be VBD cord-335975-m6lkrehi 2504 3 responsible responsible JJ cord-335975-m6lkrehi 2504 4 for for IN cord-335975-m6lkrehi 2504 5 a a DT cord-335975-m6lkrehi 2504 6 significantly significantly RB cord-335975-m6lkrehi 2504 7 deeper deep JJR cord-335975-m6lkrehi 2504 8 coma coma NN cord-335975-m6lkrehi 2504 9 ( ( -LRB- cord-335975-m6lkrehi 2504 10 p p NN cord-335975-m6lkrehi 2504 11 < < XX cord-335975-m6lkrehi 2504 12 0.0001 0.0001 CD cord-335975-m6lkrehi 2504 13 ) ) -RRB- cord-335975-m6lkrehi 2504 14 but but CC cord-335975-m6lkrehi 2504 15 fewer few JJR cord-335975-m6lkrehi 2504 16 seizures seizure NNS cord-335975-m6lkrehi 2504 17 than than IN cord-335975-m6lkrehi 2504 18 CLO CLO NNP cord-335975-m6lkrehi 2504 19 ( ( -LRB- cord-335975-m6lkrehi 2504 20 p p NN cord-335975-m6lkrehi 2504 21 = = SYM cord-335975-m6lkrehi 2504 22 0.02 0.02 CD cord-335975-m6lkrehi 2504 23 ) ) -RRB- cord-335975-m6lkrehi 2504 24 . . . cord-335975-m6lkrehi 2505 1 Three three CD cord-335975-m6lkrehi 2505 2 patients patient NNS cord-335975-m6lkrehi 2505 3 ( ( -LRB- cord-335975-m6lkrehi 2505 4 5 5 CD cord-335975-m6lkrehi 2505 5 % % NN cord-335975-m6lkrehi 2505 6 ) ) -RRB- cord-335975-m6lkrehi 2505 7 died die VBD cord-335975-m6lkrehi 2505 8 . . . cord-335975-m6lkrehi 2506 1 Based base VBN cord-335975-m6lkrehi 2506 2 on on IN cord-335975-m6lkrehi 2506 3 a a DT cord-335975-m6lkrehi 2506 4 univariate univariate JJ cord-335975-m6lkrehi 2506 5 analysis analysis NN cord-335975-m6lkrehi 2506 6 , , , cord-335975-m6lkrehi 2506 7 factors factor NNS cord-335975-m6lkrehi 2506 8 associated associate VBN cord-335975-m6lkrehi 2506 9 with with IN cord-335975-m6lkrehi 2506 10 death death NN cord-335975-m6lkrehi 2506 11 were be VBD cord-335975-m6lkrehi 2506 12 cardiac cardiac JJ cord-335975-m6lkrehi 2506 13 arrest arrest NN cord-335975-m6lkrehi 2506 14 onset onset NN cord-335975-m6lkrehi 2506 15 ( ( -LRB- cord-335975-m6lkrehi 2506 16 p p NN cord-335975-m6lkrehi 2506 17 = = SYM cord-335975-m6lkrehi 2506 18 0.003 0.003 CD cord-335975-m6lkrehi 2506 19 ) ) -RRB- cord-335975-m6lkrehi 2506 20 , , , cord-335975-m6lkrehi 2506 21 elevated elevated JJ cord-335975-m6lkrehi 2506 22 plasma plasma NN cord-335975-m6lkrehi 2506 23 lactate lactate NN cord-335975-m6lkrehi 2506 24 concentration concentration NN cord-335975-m6lkrehi 2506 25 ( ( -LRB- cord-335975-m6lkrehi 2506 26 p p NN cord-335975-m6lkrehi 2506 27 = = SYM cord-335975-m6lkrehi 2506 28 0.005 0.005 CD cord-335975-m6lkrehi 2506 29 ) ) -RRB- cord-335975-m6lkrehi 2506 30 , , , cord-335975-m6lkrehi 2506 31 low low JJ cord-335975-m6lkrehi 2506 32 arterial arterial NN cord-335975-m6lkrehi 2507 1 pH pH NNP cord-335975-m6lkrehi 2507 2 ( ( -LRB- cord-335975-m6lkrehi 2507 3 p p NN cord-335975-m6lkrehi 2507 4 = = SYM cord-335975-m6lkrehi 2507 5 0.007 0.007 CD cord-335975-m6lkrehi 2507 6 ) ) -RRB- cord-335975-m6lkrehi 2507 7 , , , cord-335975-m6lkrehi 2507 8 reduced reduce VBN cord-335975-m6lkrehi 2507 9 PaO2 pao2 JJ cord-335975-m6lkrehi 2507 10 FiO2 FiO2 NNS cord-335975-m6lkrehi 2507 11 ratio ratio NN cord-335975-m6lkrehi 2507 12 ( ( -LRB- cord-335975-m6lkrehi 2507 13 p p NN cord-335975-m6lkrehi 2507 14 = = SYM cord-335975-m6lkrehi 2507 15 0.007 0.007 CD cord-335975-m6lkrehi 2507 16 ) ) -RRB- cord-335975-m6lkrehi 2507 17 and and CC cord-335975-m6lkrehi 2507 18 prothrombine prothrombine NN cord-335975-m6lkrehi 2507 19 ratio ratio NN cord-335975-m6lkrehi 2507 20 ( ( -LRB- cord-335975-m6lkrehi 2507 21 p p NN cord-335975-m6lkrehi 2507 22 = = SYM cord-335975-m6lkrehi 2507 23 0.008 0.008 CD cord-335975-m6lkrehi 2507 24 ) ) -RRB- cord-335975-m6lkrehi 2507 25 , , , cord-335975-m6lkrehi 2507 26 increased increase VBN cord-335975-m6lkrehi 2507 27 aspartate aspartate NN cord-335975-m6lkrehi 2507 28 aminotransferases aminotransferases NNPS cord-335975-m6lkrehi 2507 29 ( ( -LRB- cord-335975-m6lkrehi 2507 30 p p NN cord-335975-m6lkrehi 2507 31 = = SYM cord-335975-m6lkrehi 2507 32 0.009 0.009 CD cord-335975-m6lkrehi 2507 33 ) ) -RRB- cord-335975-m6lkrehi 2507 34 , , , cord-335975-m6lkrehi 2507 35 alanine alanine NNP cord-335975-m6lkrehi 2507 36 aminotransferases aminotransferases NNP cord-335975-m6lkrehi 2507 37 ( ( -LRB- cord-335975-m6lkrehi 2507 38 p p NN cord-335975-m6lkrehi 2507 39 = = SYM cord-335975-m6lkrehi 2507 40 0.01 0.01 CD cord-335975-m6lkrehi 2507 41 ) ) -RRB- cord-335975-m6lkrehi 2507 42 and and CC cord-335975-m6lkrehi 2507 43 serum serum NN cord-335975-m6lkrehi 2507 44 creatinine creatinine NN cord-335975-m6lkrehi 2507 45 concentration concentration NN cord-335975-m6lkrehi 2507 46 ( ( -LRB- cord-335975-m6lkrehi 2507 47 p p NN cord-335975-m6lkrehi 2507 48 = = SYM cord-335975-m6lkrehi 2507 49 0.01 0.01 CD cord-335975-m6lkrehi 2507 50 ) ) -RRB- cord-335975-m6lkrehi 2507 51 as as RB cord-335975-m6lkrehi 2507 52 well well RB cord-335975-m6lkrehi 2507 53 as as IN cord-335975-m6lkrehi 2507 54 marked mark VBN cord-335975-m6lkrehi 2507 55 catecholamine catecholamine NN cord-335975-m6lkrehi 2507 56 infusion infusion NN cord-335975-m6lkrehi 2507 57 rate rate NN cord-335975-m6lkrehi 2507 58 ( ( -LRB- cord-335975-m6lkrehi 2507 59 p p NN cord-335975-m6lkrehi 2507 60 = = SYM cord-335975-m6lkrehi 2507 61 0.02 0.02 CD cord-335975-m6lkrehi 2507 62 ) ) -RRB- cord-335975-m6lkrehi 2507 63 . . . cord-335975-m6lkrehi 2508 1 The the DT cord-335975-m6lkrehi 2508 2 pharmacokinetic pharmacokinetic JJ cord-335975-m6lkrehi 2508 3 study study NN cord-335975-m6lkrehi 2508 4 showed show VBD cord-335975-m6lkrehi 2508 5 significant significant JJ cord-335975-m6lkrehi 2508 6 increase increase NN cord-335975-m6lkrehi 2508 7 in in IN cord-335975-m6lkrehi 2508 8 AMI AMI NNP cord-335975-m6lkrehi 2508 9 ( ( -LRB- cord-335975-m6lkrehi 2508 10 43 43 CD cord-335975-m6lkrehi 2508 11 h h NN cord-335975-m6lkrehi 2508 12 vs. vs. FW cord-335975-m6lkrehi 2508 13 24 24 CD cord-335975-m6lkrehi 2508 14 h h NNP cord-335975-m6lkrehi 2508 15 ) ) -RRB- cord-335975-m6lkrehi 2508 16 and and CC cord-335975-m6lkrehi 2508 17 CLO CLO NNP cord-335975-m6lkrehi 2508 18 ( ( -LRB- cord-335975-m6lkrehi 2508 19 55 55 CD cord-335975-m6lkrehi 2508 20 h h NN cord-335975-m6lkrehi 2508 21 vs. vs. NN cord-335975-m6lkrehi 2508 22 21 21 CD cord-335975-m6lkrehi 2508 23 h h NN cord-335975-m6lkrehi 2508 24 ) ) -RRB- cord-335975-m6lkrehi 2508 25 elimination elimination NN cord-335975-m6lkrehi 2508 26 half half RB cord-335975-m6lkrehi 2508 27 - - HYPH cord-335975-m6lkrehi 2508 28 lives life NNS cord-335975-m6lkrehi 2508 29 in in IN cord-335975-m6lkrehi 2508 30 overdose overdose NN cord-335975-m6lkrehi 2508 31 compared compare VBN cord-335975-m6lkrehi 2508 32 to to IN cord-335975-m6lkrehi 2508 33 pharmacological pharmacological JJ cord-335975-m6lkrehi 2508 34 conditions condition NNS cord-335975-m6lkrehi 2508 35 , , , cord-335975-m6lkrehi 2508 36 highlighting highlight VBG cord-335975-m6lkrehi 2508 37 the the DT cord-335975-m6lkrehi 2508 38 contribution contribution NN cord-335975-m6lkrehi 2508 39 of of IN cord-335975-m6lkrehi 2508 40 organ organ NN cord-335975-m6lkrehi 2508 41 failure failure NN cord-335975-m6lkrehi 2508 42 to to IN cord-335975-m6lkrehi 2508 43 the the DT cord-335975-m6lkrehi 2508 44 delayed delay VBN cord-335975-m6lkrehi 2508 45 elimination elimination NN cord-335975-m6lkrehi 2508 46 of of IN cord-335975-m6lkrehi 2508 47 both both DT cord-335975-m6lkrehi 2508 48 toxicants toxicant NNS cord-335975-m6lkrehi 2508 49 . . . cord-335975-m6lkrehi 2509 1 Conclusion conclusion NN cord-335975-m6lkrehi 2509 2 : : : cord-335975-m6lkrehi 2509 3 AMI AMI NNP cord-335975-m6lkrehi 2509 4 and and CC cord-335975-m6lkrehi 2509 5 CLO CLO NNP cord-335975-m6lkrehi 2509 6 poisonings poisoning NNS cord-335975-m6lkrehi 2509 7 did do VBD cord-335975-m6lkrehi 2509 8 not not RB cord-335975-m6lkrehi 2509 9 disappear disappear VB cord-335975-m6lkrehi 2509 10 and and CC cord-335975-m6lkrehi 2509 11 are be VBP cord-335975-m6lkrehi 2509 12 still still RB cord-335975-m6lkrehi 2509 13 responsible responsible JJ cord-335975-m6lkrehi 2509 14 for for IN cord-335975-m6lkrehi 2509 15 significant significant JJ cord-335975-m6lkrehi 2509 16 morbidities morbidity NNS cord-335975-m6lkrehi 2509 17 and and CC cord-335975-m6lkrehi 2509 18 mortality mortality NN cord-335975-m6lkrehi 2509 19 . . . cord-335975-m6lkrehi 2510 1 AMI AMI NNP cord-335975-m6lkrehi 2510 2 was be VBD cord-335975-m6lkrehi 2510 3 responsible responsible JJ cord-335975-m6lkrehi 2510 4 for for IN cord-335975-m6lkrehi 2510 5 deeper deep JJR cord-335975-m6lkrehi 2510 6 coma coma NN cord-335975-m6lkrehi 2510 7 with with IN cord-335975-m6lkrehi 2510 8 fewer few JJR cord-335975-m6lkrehi 2510 9 seizures seizure NNS cord-335975-m6lkrehi 2510 10 in in IN cord-335975-m6lkrehi 2510 11 comparison comparison NN cord-335975-m6lkrehi 2510 12 to to IN cord-335975-m6lkrehi 2510 13 CLO CLO NNP cord-335975-m6lkrehi 2510 14 . . . cord-335975-m6lkrehi 2511 1 AMI AMI NNP cord-335975-m6lkrehi 2511 2 and and CC cord-335975-m6lkrehi 2511 3 CLO CLO NNP cord-335975-m6lkrehi 2511 4 elimination elimination NN cord-335975-m6lkrehi 2511 5 half half RB cord-335975-m6lkrehi 2511 6 - - HYPH cord-335975-m6lkrehi 2511 7 lives life NNS cord-335975-m6lkrehi 2511 8 were be VBD cord-335975-m6lkrehi 2511 9 significantly significantly RB cord-335975-m6lkrehi 2511 10 prolonged prolong VBN cord-335975-m6lkrehi 2511 11 in in IN cord-335975-m6lkrehi 2511 12 overdose overdose NN cord-335975-m6lkrehi 2511 13 due due IN cord-335975-m6lkrehi 2511 14 to to IN cord-335975-m6lkrehi 2511 15 organ organ NN cord-335975-m6lkrehi 2511 16 failure failure NN cord-335975-m6lkrehi 2511 17 . . . cord-335975-m6lkrehi 2512 1 Introduction introduction NN cord-335975-m6lkrehi 2512 2 : : : cord-335975-m6lkrehi 2513 1 Severe severe JJ cord-335975-m6lkrehi 2513 2 poisonings poisoning NNS cord-335975-m6lkrehi 2513 3 and and CC cord-335975-m6lkrehi 2513 4 fatalities fatality NNS cord-335975-m6lkrehi 2513 5 have have VBP cord-335975-m6lkrehi 2513 6 been be VBN cord-335975-m6lkrehi 2513 7 attributed attribute VBN cord-335975-m6lkrehi 2513 8 to to IN cord-335975-m6lkrehi 2513 9 buprenorphine buprenorphine NN cord-335975-m6lkrehi 2513 10 ( ( -LRB- cord-335975-m6lkrehi 2513 11 BUP BUP NNP cord-335975-m6lkrehi 2513 12 ) ) -RRB- cord-335975-m6lkrehi 2513 13 despite despite IN cord-335975-m6lkrehi 2513 14 its -PRON- PRP$ cord-335975-m6lkrehi 2513 15 ceiling ceiling NN cord-335975-m6lkrehi 2513 16 respiratory respiratory JJ cord-335975-m6lkrehi 2513 17 effects effect NNS cord-335975-m6lkrehi 2513 18 , , , cord-335975-m6lkrehi 2513 19 mainly mainly RB cord-335975-m6lkrehi 2513 20 if if IN cord-335975-m6lkrehi 2513 21 abused abuse VBN cord-335975-m6lkrehi 2513 22 in in IN cord-335975-m6lkrehi 2513 23 co co NN cord-335975-m6lkrehi 2513 24 - - NN cord-335975-m6lkrehi 2513 25 ingestion ingestion NN cord-335975-m6lkrehi 2513 26 with with IN cord-335975-m6lkrehi 2513 27 benzodiazepines benzodiazepine NNS cord-335975-m6lkrehi 2513 28 . . . cord-335975-m6lkrehi 2514 1 We -PRON- PRP cord-335975-m6lkrehi 2514 2 previously previously RB cord-335975-m6lkrehi 2514 3 showed show VBD cord-335975-m6lkrehi 2514 4 that that IN cord-335975-m6lkrehi 2514 5 diazepam diazepam NN cord-335975-m6lkrehi 2514 6 ( ( -LRB- cord-335975-m6lkrehi 2514 7 DZP DZP NNP cord-335975-m6lkrehi 2514 8 ) ) -RRB- cord-335975-m6lkrehi 2514 9 BUP BUP NNP cord-335975-m6lkrehi 2514 10 combination combination NN cord-335975-m6lkrehi 2514 11 induces induce VBZ cord-335975-m6lkrehi 2514 12 severe severe JJ cord-335975-m6lkrehi 2514 13 respiratory respiratory JJ cord-335975-m6lkrehi 2514 14 depression depression NN cord-335975-m6lkrehi 2514 15 in in IN cord-335975-m6lkrehi 2514 16 the the DT cord-335975-m6lkrehi 2514 17 rat rat NN cord-335975-m6lkrehi 2514 18 , , , cord-335975-m6lkrehi 2514 19 while while IN cord-335975-m6lkrehi 2514 20 each each DT cord-335975-m6lkrehi 2514 21 drug drug NN cord-335975-m6lkrehi 2514 22 by by IN cord-335975-m6lkrehi 2514 23 itself -PRON- PRP cord-335975-m6lkrehi 2514 24 does do VBZ cord-335975-m6lkrehi 2514 25 not not RB cord-335975-m6lkrehi 2514 26 . . . cord-335975-m6lkrehi 2515 1 The the DT cord-335975-m6lkrehi 2515 2 objective objective NN cord-335975-m6lkrehi 2515 3 of of IN cord-335975-m6lkrehi 2515 4 this this DT cord-335975-m6lkrehi 2515 5 study study NN cord-335975-m6lkrehi 2515 6 was be VBD cord-335975-m6lkrehi 2515 7 to to TO cord-335975-m6lkrehi 2515 8 investigate investigate VB cord-335975-m6lkrehi 2515 9 the the DT cord-335975-m6lkrehi 2515 10 mechanisms mechanism NNS cord-335975-m6lkrehi 2515 11 involved involve VBN cord-335975-m6lkrehi 2515 12 in in IN cord-335975-m6lkrehi 2515 13 this this DT cord-335975-m6lkrehi 2515 14 drug drug NN cord-335975-m6lkrehi 2515 15 - - HYPH cord-335975-m6lkrehi 2515 16 drug drug NN cord-335975-m6lkrehi 2515 17 interaction interaction NN cord-335975-m6lkrehi 2515 18 using use VBG cord-335975-m6lkrehi 2515 19 11C 11C NNP cord-335975-m6lkrehi 2515 20 - - HYPH cord-335975-m6lkrehi 2515 21 BUP BUP NNP cord-335975-m6lkrehi 2515 22 PET pet NN cord-335975-m6lkrehi 2515 23 imaging imaging NN cord-335975-m6lkrehi 2515 24 and and CC cord-335975-m6lkrehi 2515 25 diaphragmatic diaphragmatic JJ cord-335975-m6lkrehi 2515 26 electromyography electromyography NN cord-335975-m6lkrehi 2515 27 in in IN cord-335975-m6lkrehi 2515 28 the the DT cord-335975-m6lkrehi 2515 29 Sprague Sprague NNP cord-335975-m6lkrehi 2515 30 - - HYPH cord-335975-m6lkrehi 2515 31 Dawley Dawley NNP cord-335975-m6lkrehi 2515 32 rat rat NN cord-335975-m6lkrehi 2515 33 . . . cord-335975-m6lkrehi 2516 1 Patients patient NNS cord-335975-m6lkrehi 2516 2 and and CC cord-335975-m6lkrehi 2516 3 methods method NNS cord-335975-m6lkrehi 2516 4 : : : cord-335975-m6lkrehi 2516 5 11C 11c LS cord-335975-m6lkrehi 2516 6 - - : cord-335975-m6lkrehi 2516 7 BUP BUP NNP cord-335975-m6lkrehi 2516 8 was be VBD cord-335975-m6lkrehi 2516 9 administered administer VBN cord-335975-m6lkrehi 2516 10 intravenously intravenously RB cord-335975-m6lkrehi 2516 11 , , , cord-335975-m6lkrehi 2516 12 30 30 CD cord-335975-m6lkrehi 2516 13 mg mg NN cord-335975-m6lkrehi 2516 14 kg kg NNP cord-335975-m6lkrehi 2516 15 unlabeled unlabeled JJ cord-335975-m6lkrehi 2516 16 BUP BUP NNP cord-335975-m6lkrehi 2516 17 intraperitoneally intraperitoneally RB cord-335975-m6lkrehi 2516 18 and and CC cord-335975-m6lkrehi 2517 1 20 20 CD cord-335975-m6lkrehi 2517 2 mg mg NN cord-335975-m6lkrehi 2517 3 kg kg NNP cord-335975-m6lkrehi 2517 4 DZP DZP NNP cord-335975-m6lkrehi 2517 5 subcutaneously subcutaneously RB cord-335975-m6lkrehi 2517 6 . . . cord-335975-m6lkrehi 2518 1 PET pet JJ cord-335975-m6lkrehi 2518 2 acquisition acquisition NN cord-335975-m6lkrehi 2518 3 started start VBD cord-335975-m6lkrehi 2518 4 with with IN cord-335975-m6lkrehi 2518 5 11C 11C NNP cord-335975-m6lkrehi 2518 6 - - HYPH cord-335975-m6lkrehi 2518 7 BUP BUP NNP cord-335975-m6lkrehi 2518 8 PET pet NN cord-335975-m6lkrehi 2518 9 injection injection NN cord-335975-m6lkrehi 2518 10 , , , cord-335975-m6lkrehi 2518 11 15 15 CD cord-335975-m6lkrehi 2518 12 min min NN cord-335975-m6lkrehi 2518 13 after after IN cord-335975-m6lkrehi 2518 14 DZP DZP NNP cord-335975-m6lkrehi 2518 15 or or CC cord-335975-m6lkrehi 2518 16 its -PRON- PRP$ cord-335975-m6lkrehi 2518 17 vehicle vehicle NN cord-335975-m6lkrehi 2518 18 ( ( -LRB- cord-335975-m6lkrehi 2518 19 VEH VEH NNP cord-335975-m6lkrehi 2518 20 + + CC cord-335975-m6lkrehi 2518 21 N n NN cord-335975-m6lkrehi 2518 22 = = SYM cord-335975-m6lkrehi 2518 23 5 5 CD cord-335975-m6lkrehi 2518 24 group group NN cord-335975-m6lkrehi 2518 25 ) ) -RRB- cord-335975-m6lkrehi 2518 26 administration administration NN cord-335975-m6lkrehi 2518 27 . . . cord-335975-m6lkrehi 2519 1 SUV SUV NNP cord-335975-m6lkrehi 2519 2 normalized normalize VBD cord-335975-m6lkrehi 2519 3 time time NN cord-335975-m6lkrehi 2519 4 activity activity NN cord-335975-m6lkrehi 2519 5 curves curve NNS cord-335975-m6lkrehi 2519 6 ( ( -LRB- cord-335975-m6lkrehi 2519 7 TACs tac NNS cord-335975-m6lkrehi 2519 8 ) ) -RRB- cord-335975-m6lkrehi 2519 9 were be VBD cord-335975-m6lkrehi 2519 10 generated generate VBN cord-335975-m6lkrehi 2519 11 and and CC cord-335975-m6lkrehi 2519 12 11C 11c LS cord-335975-m6lkrehi 2519 13 - - HYPH cord-335975-m6lkrehi 2519 14 BUP BUP NNP cord-335975-m6lkrehi 2519 15 binding bind VBG cord-335975-m6lkrehi 2519 16 potential potential NN cord-335975-m6lkrehi 2519 17 [ [ -LRB- cord-335975-m6lkrehi 2519 18 BPND BPND NNP cord-335975-m6lkrehi 2519 19 , , , cord-335975-m6lkrehi 2519 20 i.e. i.e. FW cord-335975-m6lkrehi 2519 21 the the DT cord-335975-m6lkrehi 2519 22 ratio ratio NN cord-335975-m6lkrehi 2519 23 of of IN cord-335975-m6lkrehi 2519 24 the the DT cord-335975-m6lkrehi 2519 25 total total JJ cord-335975-m6lkrehi 2519 26 receptor receptor NN cord-335975-m6lkrehi 2519 27 density density NN cord-335975-m6lkrehi 2519 28 ( ( -LRB- cord-335975-m6lkrehi 2519 29 Bmax Bmax NNP cord-335975-m6lkrehi 2519 30 ) ) -RRB- cord-335975-m6lkrehi 2519 31 on on IN cord-335975-m6lkrehi 2519 32 the the DT cord-335975-m6lkrehi 2519 33 equilibrium equilibrium NN cord-335975-m6lkrehi 2519 34 dissociation dissociation NN cord-335975-m6lkrehi 2519 35 constant constant NN cord-335975-m6lkrehi 2519 36 ( ( -LRB- cord-335975-m6lkrehi 2519 37 KD KD NNP cord-335975-m6lkrehi 2519 38 ) ) -RRB- cord-335975-m6lkrehi 2519 39 ] ] -RRB- cord-335975-m6lkrehi 2519 40 were be VBD cord-335975-m6lkrehi 2519 41 modeled model VBN cord-335975-m6lkrehi 2519 42 in in IN cord-335975-m6lkrehi 2519 43 different different JJ cord-335975-m6lkrehi 2519 44 brain brain NN cord-335975-m6lkrehi 2519 45 regions region NNS cord-335975-m6lkrehi 2519 46 using use VBG cord-335975-m6lkrehi 2519 47 a a DT cord-335975-m6lkrehi 2519 48 simplified simplified JJ cord-335975-m6lkrehi 2519 49 reference reference NN cord-335975-m6lkrehi 2519 50 tissue tissue NN cord-335975-m6lkrehi 2519 51 model model NN cord-335975-m6lkrehi 2519 52 with with IN cord-335975-m6lkrehi 2519 53 cerebellum cerebellum NN cord-335975-m6lkrehi 2519 54 as as IN cord-335975-m6lkrehi 2519 55 reference reference NN cord-335975-m6lkrehi 2519 56 region region NN cord-335975-m6lkrehi 2519 57 . . . cord-335975-m6lkrehi 2520 1 dEM dEM NNP cord-335975-m6lkrehi 2520 2 , , , cord-335975-m6lkrehi 2520 3 implanted implant VBN cord-335975-m6lkrehi 2520 4 under under IN cord-335975-m6lkrehi 2520 5 anesthesia anesthesia NN cord-335975-m6lkrehi 2520 6 7 7 CD cord-335975-m6lkrehi 2520 7 days day NNS cord-335975-m6lkrehi 2520 8 before before IN cord-335975-m6lkrehi 2520 9 the the DT cord-335975-m6lkrehi 2520 10 experiment experiment NN cord-335975-m6lkrehi 2520 11 , , , cord-335975-m6lkrehi 2520 12 was be VBD cord-335975-m6lkrehi 2520 13 recorded record VBN cord-335975-m6lkrehi 2520 14 during during IN cord-335975-m6lkrehi 2520 15 240 240 CD cord-335975-m6lkrehi 2520 16 min min NNS cord-335975-m6lkrehi 2520 17 in in IN cord-335975-m6lkrehi 2520 18 rats rat NNS cord-335975-m6lkrehi 2520 19 receiving receive VBG cord-335975-m6lkrehi 2520 20 VEH VEH NNP cord-335975-m6lkrehi 2520 21 VEH VEH NNP cord-335975-m6lkrehi 2520 22 , , , cord-335975-m6lkrehi 2520 23 DZP DZP NNP cord-335975-m6lkrehi 2520 24 VEH VEH NNP cord-335975-m6lkrehi 2520 25 , , , cord-335975-m6lkrehi 2520 26 VEH VEH NNP cord-335975-m6lkrehi 2520 27 BUP BUP NNP cord-335975-m6lkrehi 2520 28 or or CC cord-335975-m6lkrehi 2520 29 DZP DZP NNP cord-335975-m6lkrehi 2520 30 BUP BUP NNP cord-335975-m6lkrehi 2521 1 ( ( -LRB- cord-335975-m6lkrehi 2521 2 N n NN cord-335975-m6lkrehi 2521 3 = = SYM cord-335975-m6lkrehi 2521 4 6 6 CD cord-335975-m6lkrehi 2521 5 group group NN cord-335975-m6lkrehi 2521 6 ) ) -RRB- cord-335975-m6lkrehi 2521 7 . . . cord-335975-m6lkrehi 2522 1 After after IN cord-335975-m6lkrehi 2522 2 filtering filter VBG cord-335975-m6lkrehi 2522 3 and and CC cord-335975-m6lkrehi 2522 4 half half JJ cord-335975-m6lkrehi 2522 5 - - HYPH cord-335975-m6lkrehi 2522 6 wave wave NN cord-335975-m6lkrehi 2522 7 rectification rectification NN cord-335975-m6lkrehi 2522 8 , , , cord-335975-m6lkrehi 2522 9 the the DT cord-335975-m6lkrehi 2522 10 first first JJ cord-335975-m6lkrehi 2522 11 60 60 CD cord-335975-m6lkrehi 2522 12 min min NN cord-335975-m6lkrehi 2522 13 AUC AUC NNP cord-335975-m6lkrehi 2522 14 of of IN cord-335975-m6lkrehi 2522 15 diaphragm diaphragm NN cord-335975-m6lkrehi 2522 16 contraction contraction NN cord-335975-m6lkrehi 2522 17 and and CC cord-335975-m6lkrehi 2522 18 workload workload NN cord-335975-m6lkrehi 2522 19 were be VBD cord-335975-m6lkrehi 2522 20 determined determine VBN cord-335975-m6lkrehi 2522 21 and and CC cord-335975-m6lkrehi 2522 22 compared compare VBN cord-335975-m6lkrehi 2522 23 between between IN cord-335975-m6lkrehi 2522 24 the the DT cord-335975-m6lkrehi 2522 25 groups group NNS cord-335975-m6lkrehi 2522 26 . . . cord-335975-m6lkrehi 2523 1 Results result NNS cord-335975-m6lkrehi 2523 2 : : : cord-335975-m6lkrehi 2524 1 TACs tac NNS cord-335975-m6lkrehi 2524 2 and and CC cord-335975-m6lkrehi 2524 3 11C 11c CD cord-335975-m6lkrehi 2524 4 - - HYPH cord-335975-m6lkrehi 2524 5 BUP BUP NNP cord-335975-m6lkrehi 2524 6 BPND BPND NNP cord-335975-m6lkrehi 2524 7 were be VBD cord-335975-m6lkrehi 2524 8 not not RB cord-335975-m6lkrehi 2524 9 different different JJ cord-335975-m6lkrehi 2524 10 between between IN cord-335975-m6lkrehi 2524 11 the the DT cord-335975-m6lkrehi 2524 12 DZP DZP NNP cord-335975-m6lkrehi 2524 13 BUP BUP NNP cord-335975-m6lkrehi 2524 14 and and CC cord-335975-m6lkrehi 2524 15 the the DT cord-335975-m6lkrehi 2524 16 VEH VEH NNP cord-335975-m6lkrehi 2524 17 BUP BUP NNP cord-335975-m6lkrehi 2524 18 groups group NNS cord-335975-m6lkrehi 2524 19 in in IN cord-335975-m6lkrehi 2524 20 all all DT cord-335975-m6lkrehi 2524 21 studied study VBN cord-335975-m6lkrehi 2524 22 brain brain NN cord-335975-m6lkrehi 2524 23 regions region NNS cord-335975-m6lkrehi 2524 24 . . . cord-335975-m6lkrehi 2525 1 Diaphragm diaphragm NN cord-335975-m6lkrehi 2525 2 contraction contraction NN cord-335975-m6lkrehi 2525 3 was be VBD cord-335975-m6lkrehi 2525 4 significantly significantly RB cord-335975-m6lkrehi 2525 5 increased increase VBN cord-335975-m6lkrehi 2525 6 in in IN cord-335975-m6lkrehi 2525 7 the the DT cord-335975-m6lkrehi 2525 8 VEH VEH NNP cord-335975-m6lkrehi 2525 9 BUP BUP NNP cord-335975-m6lkrehi 2525 10 group group NN cord-335975-m6lkrehi 2525 11 in in IN cord-335975-m6lkrehi 2525 12 comparison comparison NN cord-335975-m6lkrehi 2525 13 to to IN cord-335975-m6lkrehi 2525 14 the the DT cord-335975-m6lkrehi 2525 15 DZP DZP NNP cord-335975-m6lkrehi 2525 16 BUP BUP NNP cord-335975-m6lkrehi 2525 17 group group NN cord-335975-m6lkrehi 2525 18 ( ( -LRB- cord-335975-m6lkrehi 2525 19 p p NN cord-335975-m6lkrehi 2525 20 < < XX cord-335975-m6lkrehi 2525 21 0.05 0.05 CD cord-335975-m6lkrehi 2525 22 ) ) -RRB- cord-335975-m6lkrehi 2525 23 . . . cord-335975-m6lkrehi 2526 1 Diaphragm diaphragm NN cord-335975-m6lkrehi 2526 2 workload workload NN cord-335975-m6lkrehi 2526 3 was be VBD cord-335975-m6lkrehi 2526 4 significantly significantly RB cord-335975-m6lkrehi 2526 5 increased increase VBN cord-335975-m6lkrehi 2526 6 in in IN cord-335975-m6lkrehi 2526 7 the the DT cord-335975-m6lkrehi 2526 8 VEH VEH NNP cord-335975-m6lkrehi 2526 9 BUP BUP NNP cord-335975-m6lkrehi 2526 10 group group NN cord-335975-m6lkrehi 2526 11 in in IN cord-335975-m6lkrehi 2526 12 comparison comparison NN cord-335975-m6lkrehi 2526 13 to to IN cord-335975-m6lkrehi 2526 14 the the DT cord-335975-m6lkrehi 2526 15 DZP DZP NNP cord-335975-m6lkrehi 2526 16 VEH VEH NNP cord-335975-m6lkrehi 2526 17 and and CC cord-335975-m6lkrehi 2526 18 the the DT cord-335975-m6lkrehi 2526 19 DZP DZP NNP cord-335975-m6lkrehi 2526 20 BUP BUP NNP cord-335975-m6lkrehi 2526 21 group group NN cord-335975-m6lkrehi 2526 22 ( ( -LRB- cord-335975-m6lkrehi 2526 23 p p NN cord-335975-m6lkrehi 2526 24 < < XX cord-335975-m6lkrehi 2526 25 0.05 0.05 CD cord-335975-m6lkrehi 2526 26 and and CC cord-335975-m6lkrehi 2526 27 p p NN cord-335975-m6lkrehi 2526 28 < < XX cord-335975-m6lkrehi 2526 29 0.01 0.01 CD cord-335975-m6lkrehi 2526 30 respectively respectively RB cord-335975-m6lkrehi 2526 31 ) ) -RRB- cord-335975-m6lkrehi 2526 32 . . . cord-335975-m6lkrehi 2527 1 Discussion discussion NN cord-335975-m6lkrehi 2527 2 : : : cord-335975-m6lkrehi 2528 1 DZP DZP NNP cord-335975-m6lkrehi 2528 2 did do VBD cord-335975-m6lkrehi 2528 3 not not RB cord-335975-m6lkrehi 2528 4 affect affect VB cord-335975-m6lkrehi 2528 5 the the DT cord-335975-m6lkrehi 2528 6 11C 11C NNP cord-335975-m6lkrehi 2528 7 - - HYPH cord-335975-m6lkrehi 2528 8 BUP BUP NNP cord-335975-m6lkrehi 2528 9 brain brain NN cord-335975-m6lkrehi 2528 10 distribution distribution NN cord-335975-m6lkrehi 2528 11 and and CC cord-335975-m6lkrehi 2528 12 brain brain NN cord-335975-m6lkrehi 2528 13 binding binding NN cord-335975-m6lkrehi 2528 14 suggesting suggest VBG cord-335975-m6lkrehi 2528 15 that that IN cord-335975-m6lkrehi 2528 16 DZP DZP NNP cord-335975-m6lkrehi 2528 17 does do VBZ cord-335975-m6lkrehi 2528 18 not not RB cord-335975-m6lkrehi 2528 19 affect affect VB cord-335975-m6lkrehi 2528 20 BUP BUP NNP cord-335975-m6lkrehi 2528 21 transport transport NN cord-335975-m6lkrehi 2528 22 across across IN cord-335975-m6lkrehi 2528 23 the the DT cord-335975-m6lkrehi 2528 24 blood blood NN cord-335975-m6lkrehi 2528 25 brain brain NN cord-335975-m6lkrehi 2528 26 barrier barrier NN cord-335975-m6lkrehi 2528 27 and and CC cord-335975-m6lkrehi 2528 28 BUP BUP NNP cord-335975-m6lkrehi 2528 29 receptors receptor NNS cord-335975-m6lkrehi 2528 30 density density NN cord-335975-m6lkrehi 2528 31 affinity affinity NN cord-335975-m6lkrehi 2528 32 . . . cord-335975-m6lkrehi 2529 1 BUP BUP NNP cord-335975-m6lkrehi 2529 2 administration administration NN cord-335975-m6lkrehi 2529 3 induced induce VBD cord-335975-m6lkrehi 2529 4 an an DT cord-335975-m6lkrehi 2529 5 increase increase NN cord-335975-m6lkrehi 2529 6 in in IN cord-335975-m6lkrehi 2529 7 diaphragm diaphragm NN cord-335975-m6lkrehi 2529 8 contraction contraction NN cord-335975-m6lkrehi 2529 9 and and CC cord-335975-m6lkrehi 2529 10 workload workload NN cord-335975-m6lkrehi 2529 11 . . . cord-335975-m6lkrehi 2530 1 This this DT cord-335975-m6lkrehi 2530 2 increase increase NN cord-335975-m6lkrehi 2530 3 was be VBD cord-335975-m6lkrehi 2530 4 inhibited inhibit VBN cord-335975-m6lkrehi 2530 5 in in IN cord-335975-m6lkrehi 2530 6 the the DT cord-335975-m6lkrehi 2530 7 presence presence NN cord-335975-m6lkrehi 2530 8 of of IN cord-335975-m6lkrehi 2530 9 DZP DZP NNP cord-335975-m6lkrehi 2530 10 suggesting suggest VBG cord-335975-m6lkrehi 2530 11 that that IN cord-335975-m6lkrehi 2530 12 DZP DZP NNP cord-335975-m6lkrehi 2530 13 BUP BUP NNP cord-335975-m6lkrehi 2530 14 combination combination NN cord-335975-m6lkrehi 2530 15 - - HYPH cord-335975-m6lkrehi 2530 16 induced induce VBN cord-335975-m6lkrehi 2530 17 respiratory respiratory JJ cord-335975-m6lkrehi 2530 18 depression depression NN cord-335975-m6lkrehi 2530 19 is be VBZ cord-335975-m6lkrehi 2530 20 mostly mostly RB cord-335975-m6lkrehi 2530 21 related relate VBN cord-335975-m6lkrehi 2530 22 to to IN cord-335975-m6lkrehi 2530 23 DZP DZP NNP cord-335975-m6lkrehi 2530 24 . . . cord-335975-m6lkrehi 2531 1 Conclusion conclusion NN cord-335975-m6lkrehi 2531 2 : : : cord-335975-m6lkrehi 2531 3 Respiratory respiratory JJ cord-335975-m6lkrehi 2531 4 depression depression NN cord-335975-m6lkrehi 2531 5 related relate VBN cord-335975-m6lkrehi 2531 6 to to IN cord-335975-m6lkrehi 2531 7 DZP DZP NNP cord-335975-m6lkrehi 2531 8 BUP BUP NNP cord-335975-m6lkrehi 2531 9 combination combination NN cord-335975-m6lkrehi 2531 10 results result NNS cord-335975-m6lkrehi 2531 11 from from IN cord-335975-m6lkrehi 2531 12 a a DT cord-335975-m6lkrehi 2531 13 pharmacodynamic pharmacodynamic JJ cord-335975-m6lkrehi 2531 14 drug drug NN cord-335975-m6lkrehi 2531 15 - - HYPH cord-335975-m6lkrehi 2531 16 drug drug NN cord-335975-m6lkrehi 2531 17 interaction interaction NN cord-335975-m6lkrehi 2531 18 . . . cord-335975-m6lkrehi 2532 1 Introduction introduction NN cord-335975-m6lkrehi 2532 2 : : : cord-335975-m6lkrehi 2533 1 Since since IN cord-335975-m6lkrehi 2533 2 the the DT cord-335975-m6lkrehi 2533 3 banning banning NN cord-335975-m6lkrehi 2533 4 of of IN cord-335975-m6lkrehi 2533 5 dextropropoxyphene dextropropoxyphene NN cord-335975-m6lkrehi 2533 6 from from IN cord-335975-m6lkrehi 2533 7 the the DT cord-335975-m6lkrehi 2533 8 market market NN cord-335975-m6lkrehi 2533 9 , , , cord-335975-m6lkrehi 2533 10 overdoses overdose NNS cord-335975-m6lkrehi 2533 11 and and CC cord-335975-m6lkrehi 2533 12 fatalities fatality NNS cord-335975-m6lkrehi 2533 13 attributed attribute VBN cord-335975-m6lkrehi 2533 14 to to IN cord-335975-m6lkrehi 2533 15 tramadol tramadol NN cord-335975-m6lkrehi 2533 16 , , , cord-335975-m6lkrehi 2533 17 a a DT cord-335975-m6lkrehi 2533 18 WHO WHO NNP cord-335975-m6lkrehi 2533 19 step-2 step-2 NNP cord-335975-m6lkrehi 2533 20 opioid opioid JJ cord-335975-m6lkrehi 2533 21 analgesic analgesic NN cord-335975-m6lkrehi 2533 22 , , , cord-335975-m6lkrehi 2533 23 have have VBP cord-335975-m6lkrehi 2533 24 increased increase VBN cord-335975-m6lkrehi 2533 25 markedly markedly RB cord-335975-m6lkrehi 2533 26 . . . cord-335975-m6lkrehi 2534 1 Tramadol tramadol NN cord-335975-m6lkrehi 2534 2 overdose overdose NN cord-335975-m6lkrehi 2534 3 results result NNS cord-335975-m6lkrehi 2534 4 not not RB cord-335975-m6lkrehi 2534 5 only only RB cord-335975-m6lkrehi 2534 6 in in IN cord-335975-m6lkrehi 2534 7 central central JJ cord-335975-m6lkrehi 2534 8 nervous nervous JJ cord-335975-m6lkrehi 2534 9 system system NN cord-335975-m6lkrehi 2534 10 ( ( -LRB- cord-335975-m6lkrehi 2534 11 CNS CNS NNP cord-335975-m6lkrehi 2534 12 ) ) -RRB- cord-335975-m6lkrehi 2534 13 depression depression NN cord-335975-m6lkrehi 2534 14 attributed attribute VBN cord-335975-m6lkrehi 2534 15 to to IN cord-335975-m6lkrehi 2534 16 its -PRON- PRP$ cord-335975-m6lkrehi 2534 17 opioid opioid JJ cord-335975-m6lkrehi 2534 18 properties property NNS cord-335975-m6lkrehi 2534 19 but but CC cord-335975-m6lkrehi 2534 20 also also RB cord-335975-m6lkrehi 2534 21 in in IN cord-335975-m6lkrehi 2534 22 seizures seizure NNS cord-335975-m6lkrehi 2534 23 , , , cord-335975-m6lkrehi 2534 24 possibly possibly RB cord-335975-m6lkrehi 2534 25 related relate VBN cord-335975-m6lkrehi 2534 26 to to IN cord-335975-m6lkrehi 2534 27 nonopioidergic nonopioidergic JJ cord-335975-m6lkrehi 2534 28 pathways pathway NNS cord-335975-m6lkrehi 2534 29 , , , cord-335975-m6lkrehi 2534 30 thus thus RB cord-335975-m6lkrehi 2534 31 questioning question VBG cord-335975-m6lkrehi 2534 32 the the DT cord-335975-m6lkrehi 2534 33 efficiency efficiency NN cord-335975-m6lkrehi 2534 34 of of IN cord-335975-m6lkrehi 2534 35 naloxone naloxone NN cord-335975-m6lkrehi 2534 36 to to TO cord-335975-m6lkrehi 2534 37 reverse reverse VB cord-335975-m6lkrehi 2534 38 tramadol tramadol NN cord-335975-m6lkrehi 2534 39 - - HYPH cord-335975-m6lkrehi 2534 40 induced induce VBN cord-335975-m6lkrehi 2534 41 CNS CNS NNP cord-335975-m6lkrehi 2534 42 toxicity toxicity NN cord-335975-m6lkrehi 2534 43 . . . cord-335975-m6lkrehi 2535 1 Our -PRON- PRP$ cord-335975-m6lkrehi 2535 2 objective objective NN cord-335975-m6lkrehi 2535 3 was be VBD cord-335975-m6lkrehi 2535 4 to to TO cord-335975-m6lkrehi 2535 5 investigate investigate VB cord-335975-m6lkrehi 2535 6 the the DT cord-335975-m6lkrehi 2535 7 most most RBS cord-335975-m6lkrehi 2535 8 efficient efficient JJ cord-335975-m6lkrehi 2535 9 antidote antidote NN cord-335975-m6lkrehi 2535 10 to to TO cord-335975-m6lkrehi 2535 11 reverse reverse VB cord-335975-m6lkrehi 2535 12 tramadol tramadol NN cord-335975-m6lkrehi 2535 13 - - HYPH cord-335975-m6lkrehi 2535 14 induced induce VBN cord-335975-m6lkrehi 2535 15 seizures seizure NNS cord-335975-m6lkrehi 2535 16 and and CC cord-335975-m6lkrehi 2535 17 respiratory respiratory JJ cord-335975-m6lkrehi 2535 18 depression depression NN cord-335975-m6lkrehi 2535 19 in in IN cord-335975-m6lkrehi 2535 20 overdose overdose NN cord-335975-m6lkrehi 2535 21 . . . cord-335975-m6lkrehi 2536 1 Patients patient NNS cord-335975-m6lkrehi 2536 2 and and CC cord-335975-m6lkrehi 2536 3 methods method NNS cord-335975-m6lkrehi 2536 4 : : : cord-335975-m6lkrehi 2536 5 Sprague Sprague NNP cord-335975-m6lkrehi 2536 6 - - HYPH cord-335975-m6lkrehi 2536 7 Dawley Dawley NNP cord-335975-m6lkrehi 2536 8 rats rat NNS cord-335975-m6lkrehi 2536 9 overdosed overdose VBD cord-335975-m6lkrehi 2536 10 with with IN cord-335975-m6lkrehi 2536 11 75 75 CD cord-335975-m6lkrehi 2536 12 mg mg NNP cord-335975-m6lkrehi 2536 13 kg kg NNP cord-335975-m6lkrehi 2536 14 intraperitoneal intraperitoneal JJ cord-335975-m6lkrehi 2536 15 ( ( -LRB- cord-335975-m6lkrehi 2536 16 IP IP NNP cord-335975-m6lkrehi 2536 17 ) ) -RRB- cord-335975-m6lkrehi 2536 18 tramadol tramadol NN cord-335975-m6lkrehi 2536 19 were be VBD cord-335975-m6lkrehi 2536 20 randomized randomize VBN cord-335975-m6lkrehi 2536 21 into into IN cord-335975-m6lkrehi 2536 22 four four CD cord-335975-m6lkrehi 2536 23 groups group NNS cord-335975-m6lkrehi 2536 24 to to TO cord-335975-m6lkrehi 2536 25 receive receive VB cord-335975-m6lkrehi 2536 26 solvent solvent NN cord-335975-m6lkrehi 2536 27 ( ( -LRB- cord-335975-m6lkrehi 2536 28 control control NN cord-335975-m6lkrehi 2536 29 group group NN cord-335975-m6lkrehi 2536 30 ) ) -RRB- cord-335975-m6lkrehi 2536 31 , , , cord-335975-m6lkrehi 2536 32 diazepam diazepam NN cord-335975-m6lkrehi 2536 33 ( ( -LRB- cord-335975-m6lkrehi 2536 34 1.77 1.77 CD cord-335975-m6lkrehi 2536 35 mg mg NNP cord-335975-m6lkrehi 2536 36 kg kg NNP cord-335975-m6lkrehi 2536 37 IP IP NNP cord-335975-m6lkrehi 2536 38 ) ) -RRB- cord-335975-m6lkrehi 2536 39 , , , cord-335975-m6lkrehi 2536 40 naloxone naloxone NN cord-335975-m6lkrehi 2536 41 ( ( -LRB- cord-335975-m6lkrehi 2536 42 2 2 CD cord-335975-m6lkrehi 2536 43 mg mg NNP cord-335975-m6lkrehi 2536 44 kg kg NNP cord-335975-m6lkrehi 2536 45 intravenous intravenous JJ cord-335975-m6lkrehi 2536 46 bolus bolus NN cord-335975-m6lkrehi 2536 47 followed follow VBD cord-335975-m6lkrehi 2536 48 by by IN cord-335975-m6lkrehi 2536 49 4 4 CD cord-335975-m6lkrehi 2536 50 mg mg NNP cord-335975-m6lkrehi 2536 51 kg kg NNP cord-335975-m6lkrehi 2536 52 h h NN cord-335975-m6lkrehi 2536 53 infusion infusion NN cord-335975-m6lkrehi 2536 54 ) ) -RRB- cord-335975-m6lkrehi 2536 55 and and CC cord-335975-m6lkrehi 2536 56 diazepam diazepam NNP cord-335975-m6lkrehi 2536 57 naloxone naloxone NNP cord-335975-m6lkrehi 2536 58 combination combination NN cord-335975-m6lkrehi 2536 59 . . . cord-335975-m6lkrehi 2537 1 Sedation sedation NN cord-335975-m6lkrehi 2537 2 depth depth NN cord-335975-m6lkrehi 2537 3 , , , cord-335975-m6lkrehi 2537 4 temperature temperature NN cord-335975-m6lkrehi 2537 5 , , , cord-335975-m6lkrehi 2537 6 number number NN cord-335975-m6lkrehi 2537 7 of of IN cord-335975-m6lkrehi 2537 8 seizures seizure NNS cord-335975-m6lkrehi 2537 9 and and CC cord-335975-m6lkrehi 2537 10 intensity intensity NN cord-335975-m6lkrehi 2537 11 , , , cord-335975-m6lkrehi 2537 12 whole whole JJ cord-335975-m6lkrehi 2537 13 - - HYPH cord-335975-m6lkrehi 2537 14 body body NN cord-335975-m6lkrehi 2537 15 plethysmography plethysmography NN cord-335975-m6lkrehi 2537 16 parameters parameter NNS cord-335975-m6lkrehi 2537 17 and and CC cord-335975-m6lkrehi 2537 18 electroencephalography electroencephalography NN cord-335975-m6lkrehi 2537 19 activity activity NN cord-335975-m6lkrehi 2537 20 were be VBD cord-335975-m6lkrehi 2537 21 measured measure VBN cord-335975-m6lkrehi 2537 22 . . . cord-335975-m6lkrehi 2538 1 For for IN cord-335975-m6lkrehi 2538 2 each each DT cord-335975-m6lkrehi 2538 3 parameter parameter NN cord-335975-m6lkrehi 2538 4 , , , cord-335975-m6lkrehi 2538 5 we -PRON- PRP cord-335975-m6lkrehi 2538 6 compared compare VBD cord-335975-m6lkrehi 2538 7 the the DT cord-335975-m6lkrehi 2538 8 areas area NNS cord-335975-m6lkrehi 2538 9 under under IN cord-335975-m6lkrehi 2538 10 the the DT cord-335975-m6lkrehi 2538 11 curves curve NNS cord-335975-m6lkrehi 2538 12 using use VBG cord-335975-m6lkrehi 2538 13 Mann Mann NNP cord-335975-m6lkrehi 2538 14 - - HYPH cord-335975-m6lkrehi 2538 15 Whitney Whitney NNP cord-335975-m6lkrehi 2538 16 tests test VBZ cord-335975-m6lkrehi 2538 17 for for IN cord-335975-m6lkrehi 2538 18 two two CD cord-335975-m6lkrehi 2538 19 - - HYPH cord-335975-m6lkrehi 2538 20 by by IN cord-335975-m6lkrehi 2538 21 - - HYPH cord-335975-m6lkrehi 2538 22 two two CD cord-335975-m6lkrehi 2538 23 comparisons comparison NNS cord-335975-m6lkrehi 2538 24 between between IN cord-335975-m6lkrehi 2538 25 the the DT cord-335975-m6lkrehi 2538 26 four four CD cord-335975-m6lkrehi 2538 27 groups group NNS cord-335975-m6lkrehi 2538 28 . . . cord-335975-m6lkrehi 2539 1 Regarding regard VBG cord-335975-m6lkrehi 2539 2 the the DT cord-335975-m6lkrehi 2539 3 effects effect NNS cord-335975-m6lkrehi 2539 4 of of IN cord-335975-m6lkrehi 2539 5 treatments treatment NNS cord-335975-m6lkrehi 2539 6 on on IN cord-335975-m6lkrehi 2539 7 seizures seizure NNS cord-335975-m6lkrehi 2539 8 , , , cord-335975-m6lkrehi 2539 9 comparisons comparison NNS cord-335975-m6lkrehi 2539 10 were be VBD cord-335975-m6lkrehi 2539 11 performed perform VBN cord-335975-m6lkrehi 2539 12 using use VBG cord-335975-m6lkrehi 2539 13 two two CD cord-335975-m6lkrehi 2539 14 - - HYPH cord-335975-m6lkrehi 2539 15 way way NN cord-335975-m6lkrehi 2539 16 analysis analysis NN cord-335975-m6lkrehi 2539 17 of of IN cord-335975-m6lkrehi 2539 18 variance variance NN cord-335975-m6lkrehi 2539 19 followed follow VBN cord-335975-m6lkrehi 2539 20 by by IN cord-335975-m6lkrehi 2539 21 multiple multiple JJ cord-335975-m6lkrehi 2539 22 comparison comparison NN cord-335975-m6lkrehi 2539 23 tests test NNS cord-335975-m6lkrehi 2539 24 using use VBG cord-335975-m6lkrehi 2539 25 Bonferroni Bonferroni NNP cord-335975-m6lkrehi 2539 26 's 's POS cord-335975-m6lkrehi 2539 27 correction correction NN cord-335975-m6lkrehi 2539 28 . . . cord-335975-m6lkrehi 2540 1 Results result NNS cord-335975-m6lkrehi 2540 2 : : : cord-335975-m6lkrehi 2541 1 Naloxone naloxone NN cord-335975-m6lkrehi 2541 2 reversed reverse VBD cord-335975-m6lkrehi 2541 3 tramadol tramadol NN cord-335975-m6lkrehi 2541 4 - - HYPH cord-335975-m6lkrehi 2541 5 induced induce VBN cord-335975-m6lkrehi 2541 6 respiratory respiratory JJ cord-335975-m6lkrehi 2541 7 depression depression NN cord-335975-m6lkrehi 2541 8 ( ( -LRB- cord-335975-m6lkrehi 2541 9 p p NN cord-335975-m6lkrehi 2541 10 < < XX cord-335975-m6lkrehi 2541 11 0.05 0.05 CD cord-335975-m6lkrehi 2541 12 ) ) -RRB- cord-335975-m6lkrehi 2541 13 but but CC cord-335975-m6lkrehi 2541 14 significantly significantly RB cord-335975-m6lkrehi 2541 15 increased increase VBN cord-335975-m6lkrehi 2541 16 seizures seizure NNS cord-335975-m6lkrehi 2541 17 ( ( -LRB- cord-335975-m6lkrehi 2541 18 p p NN cord-335975-m6lkrehi 2541 19 < < XX cord-335975-m6lkrehi 2541 20 0.01 0.01 CD cord-335975-m6lkrehi 2541 21 ) ) -RRB- cord-335975-m6lkrehi 2541 22 and and CC cord-335975-m6lkrehi 2541 23 prolonged prolong VBD cord-335975-m6lkrehi 2541 24 their -PRON- PRP$ cord-335975-m6lkrehi 2541 25 occurrence occurrence NN cord-335975-m6lkrehi 2541 26 time time NN cord-335975-m6lkrehi 2541 27 . . . cord-335975-m6lkrehi 2542 1 Diazepam diazepam NN cord-335975-m6lkrehi 2542 2 abolished abolish VBD cord-335975-m6lkrehi 2542 3 seizures seizure NNS cord-335975-m6lkrehi 2542 4 but but CC cord-335975-m6lkrehi 2542 5 significantly significantly RB cord-335975-m6lkrehi 2542 6 deepened deepen VBD cord-335975-m6lkrehi 2542 7 rat rat NN cord-335975-m6lkrehi 2542 8 sedation sedation NN cord-335975-m6lkrehi 2542 9 ( ( -LRB- cord-335975-m6lkrehi 2542 10 p p NN cord-335975-m6lkrehi 2542 11 < < XX cord-335975-m6lkrehi 2542 12 0.05 0.05 CD cord-335975-m6lkrehi 2542 13 ) ) -RRB- cord-335975-m6lkrehi 2542 14 without without IN cord-335975-m6lkrehi 2542 15 improving improve VBG cord-335975-m6lkrehi 2542 16 ventilation ventilation NN cord-335975-m6lkrehi 2542 17 . . . cord-335975-m6lkrehi 2543 1 Diazepam Diazepam NNP cord-335975-m6lkrehi 2543 2 naloxone naloxone NN cord-335975-m6lkrehi 2543 3 combination combination NN cord-335975-m6lkrehi 2543 4 completely completely RB cord-335975-m6lkrehi 2543 5 abolished abolish VBD cord-335975-m6lkrehi 2543 6 seizures seizure NNS cord-335975-m6lkrehi 2543 7 , , , cord-335975-m6lkrehi 2543 8 significantly significantly RB cord-335975-m6lkrehi 2543 9 improved improve VBD cord-335975-m6lkrehi 2543 10 rat rat NN cord-335975-m6lkrehi 2543 11 ventilation ventilation NN cord-335975-m6lkrehi 2543 12 by by IN cord-335975-m6lkrehi 2543 13 reducing reduce VBG cord-335975-m6lkrehi 2543 14 inspiratory inspiratory JJ cord-335975-m6lkrehi 2543 15 time time NN cord-335975-m6lkrehi 2543 16 ( ( -LRB- cord-335975-m6lkrehi 2543 17 p p NN cord-335975-m6lkrehi 2543 18 < < XX cord-335975-m6lkrehi 2543 19 0.05 0.05 CD cord-335975-m6lkrehi 2543 20 ) ) -RRB- cord-335975-m6lkrehi 2543 21 but but CC cord-335975-m6lkrehi 2543 22 did do VBD cord-335975-m6lkrehi 2543 23 not not RB cord-335975-m6lkrehi 2543 24 worsen worsen VB cord-335975-m6lkrehi 2543 25 sedation sedation NN cord-335975-m6lkrehi 2543 26 . . . cord-335975-m6lkrehi 2544 1 Based base VBN cord-335975-m6lkrehi 2544 2 on on IN cord-335975-m6lkrehi 2544 3 the the DT cord-335975-m6lkrehi 2544 4 EEG EEG NNP cord-335975-m6lkrehi 2544 5 study study NN cord-335975-m6lkrehi 2544 6 , , , cord-335975-m6lkrehi 2544 7 tramadol tramadol NN cord-335975-m6lkrehi 2544 8 - - HYPH cord-335975-m6lkrehi 2544 9 treated treat VBN cord-335975-m6lkrehi 2544 10 rats rat NNS cord-335975-m6lkrehi 2544 11 experienced experience VBD cord-335975-m6lkrehi 2544 12 electro electro JJ cord-335975-m6lkrehi 2544 13 - - HYPH cord-335975-m6lkrehi 2544 14 clinical clinical JJ cord-335975-m6lkrehi 2544 15 seizures seizure NNS cord-335975-m6lkrehi 2544 16 as as RB cord-335975-m6lkrehi 2544 17 soon soon RB cord-335975-m6lkrehi 2544 18 as as IN cord-335975-m6lkrehi 2544 19 5 5 CD cord-335975-m6lkrehi 2544 20 min min NN cord-335975-m6lkrehi 2544 21 after after IN cord-335975-m6lkrehi 2544 22 the the DT cord-335975-m6lkrehi 2544 23 injection injection NN cord-335975-m6lkrehi 2544 24 , , , cord-335975-m6lkrehi 2544 25 characterized characterize VBN cord-335975-m6lkrehi 2544 26 by by IN cord-335975-m6lkrehi 2544 27 spike spike NN cord-335975-m6lkrehi 2544 28 - - HYPH cord-335975-m6lkrehi 2544 29 waves wave NNS cord-335975-m6lkrehi 2544 30 and and CC cord-335975-m6lkrehi 2544 31 polyspikes polyspikes VBP cord-335975-m6lkrehi 2544 32 with with IN cord-335975-m6lkrehi 2544 33 progressive progressive JJ cord-335975-m6lkrehi 2544 34 decreased decreased JJ cord-335975-m6lkrehi 2544 35 frequencies frequency NNS cord-335975-m6lkrehi 2544 36 and and CC cord-335975-m6lkrehi 2544 37 inter inter JJ cord-335975-m6lkrehi 2544 38 - - JJ cord-335975-m6lkrehi 2544 39 critical critical JJ cord-335975-m6lkrehi 2544 40 phases phase NNS cord-335975-m6lkrehi 2544 41 of of IN cord-335975-m6lkrehi 2544 42 slow slow JJ cord-335975-m6lkrehi 2544 43 delta delta NN cord-335975-m6lkrehi 2544 44 waves wave NNS cord-335975-m6lkrehi 2544 45 until until IN cord-335975-m6lkrehi 2544 46 the the DT cord-335975-m6lkrehi 2544 47 next next JJ cord-335975-m6lkrehi 2544 48 crisis crisis NN cord-335975-m6lkrehi 2544 49 . . . cord-335975-m6lkrehi 2545 1 After after IN cord-335975-m6lkrehi 2545 2 diazepam diazepam NN cord-335975-m6lkrehi 2545 3 naloxone naloxone NN cord-335975-m6lkrehi 2545 4 injection injection NN cord-335975-m6lkrehi 2545 5 , , , cord-335975-m6lkrehi 2545 6 EEG EEG NNP cord-335975-m6lkrehi 2545 7 waveforms waveform NNS cord-335975-m6lkrehi 2545 8 consisted consist VBD cord-335975-m6lkrehi 2545 9 in in IN cord-335975-m6lkrehi 2545 10 8 8 CD cord-335975-m6lkrehi 2545 11 Hz Hz NNP cord-335975-m6lkrehi 2545 12 - - HYPH cord-335975-m6lkrehi 2545 13 alpha alpha NN cord-335975-m6lkrehi 2545 14 rhythms rhythm NNS cord-335975-m6lkrehi 2545 15 and and CC cord-335975-m6lkrehi 2545 16 slow slow RB cord-335975-m6lkrehi 2545 17 - - HYPH cord-335975-m6lkrehi 2545 18 down down RP cord-335975-m6lkrehi 2545 19 theta theta NN cord-335975-m6lkrehi 2545 20 rhythms rhythm NNS cord-335975-m6lkrehi 2545 21 of of IN cord-335975-m6lkrehi 2545 22 drowsiness drowsiness NN cord-335975-m6lkrehi 2545 23 . . . cord-335975-m6lkrehi 2546 1 None none NN cord-335975-m6lkrehi 2546 2 of of IN cord-335975-m6lkrehi 2546 3 these these DT cord-335975-m6lkrehi 2546 4 treatments treatment NNS cord-335975-m6lkrehi 2546 5 significantly significantly RB cord-335975-m6lkrehi 2546 6 modified modify VBN cord-335975-m6lkrehi 2546 7 rat rat NN cord-335975-m6lkrehi 2546 8 temperature temperature NN cord-335975-m6lkrehi 2546 9 . . . cord-335975-m6lkrehi 2547 1 Conclusion conclusion NN cord-335975-m6lkrehi 2547 2 : : : cord-335975-m6lkrehi 2547 3 Diazepam diazepam NN cord-335975-m6lkrehi 2547 4 naloxone naloxone NN cord-335975-m6lkrehi 2547 5 combination combination NN cord-335975-m6lkrehi 2547 6 is be VBZ cord-335975-m6lkrehi 2547 7 the the DT cord-335975-m6lkrehi 2547 8 most most RBS cord-335975-m6lkrehi 2547 9 efficient efficient JJ cord-335975-m6lkrehi 2547 10 antidote antidote NN cord-335975-m6lkrehi 2547 11 to to TO cord-335975-m6lkrehi 2547 12 reverse reverse VB cord-335975-m6lkrehi 2547 13 tramadol tramadol NN cord-335975-m6lkrehi 2547 14 - - HYPH cord-335975-m6lkrehi 2547 15 induced induce VBN cord-335975-m6lkrehi 2547 16 CNS CNS NNP cord-335975-m6lkrehi 2547 17 toxicity toxicity NN cord-335975-m6lkrehi 2547 18 . . . cord-335975-m6lkrehi 2548 1 Our -PRON- PRP$ cord-335975-m6lkrehi 2548 2 experimental experimental JJ cord-335975-m6lkrehi 2548 3 data datum NNS cord-335975-m6lkrehi 2548 4 greatly greatly RB cord-335975-m6lkrehi 2548 5 encourage encourage VBP cord-335975-m6lkrehi 2548 6 administering administer VBG cord-335975-m6lkrehi 2548 7 this this DT cord-335975-m6lkrehi 2548 8 combination combination NN cord-335975-m6lkrehi 2548 9 rather rather RB cord-335975-m6lkrehi 2548 10 than than IN cord-335975-m6lkrehi 2548 11 naloxone naloxone NN cord-335975-m6lkrehi 2548 12 alone alone RB cord-335975-m6lkrehi 2548 13 as as IN cord-335975-m6lkrehi 2548 14 first first JJ cord-335975-m6lkrehi 2548 15 - - HYPH cord-335975-m6lkrehi 2548 16 line line NN cord-335975-m6lkrehi 2548 17 antidote antidote NN cord-335975-m6lkrehi 2548 18 in in IN cord-335975-m6lkrehi 2548 19 tramadol tramadol NN cord-335975-m6lkrehi 2548 20 - - HYPH cord-335975-m6lkrehi 2548 21 poisoned poison VBN cord-335975-m6lkrehi 2548 22 patients patient NNS cord-335975-m6lkrehi 2548 23 as as IN cord-335975-m6lkrehi 2548 24 an an DT cord-335975-m6lkrehi 2548 25 alternative alternative NN cord-335975-m6lkrehi 2548 26 to to IN cord-335975-m6lkrehi 2548 27 tracheal tracheal JJ cord-335975-m6lkrehi 2548 28 intubation intubation NN cord-335975-m6lkrehi 2548 29 . . . cord-335975-m6lkrehi 2549 1 Introduction introduction NN cord-335975-m6lkrehi 2549 2 : : : cord-335975-m6lkrehi 2550 1 Rubigine Rubigine NNP cord-335975-m6lkrehi 2550 2 ® ® . cord-335975-m6lkrehi 2550 3 poisoning poisoning NN cord-335975-m6lkrehi 2550 4 is be VBZ cord-335975-m6lkrehi 2550 5 a a DT cord-335975-m6lkrehi 2550 6 medical medical JJ cord-335975-m6lkrehi 2550 7 emergency emergency NN cord-335975-m6lkrehi 2550 8 that that WDT cord-335975-m6lkrehi 2550 9 causes cause VBZ cord-335975-m6lkrehi 2550 10 a a DT cord-335975-m6lkrehi 2550 11 major major JJ cord-335975-m6lkrehi 2550 12 public public JJ cord-335975-m6lkrehi 2550 13 health health NN cord-335975-m6lkrehi 2550 14 problem problem NN cord-335975-m6lkrehi 2550 15 in in IN cord-335975-m6lkrehi 2550 16 underdeveloped underdeveloped JJ cord-335975-m6lkrehi 2550 17 countries country NNS cord-335975-m6lkrehi 2550 18 , , , cord-335975-m6lkrehi 2550 19 as as IN cord-335975-m6lkrehi 2550 20 it -PRON- PRP cord-335975-m6lkrehi 2550 21 is be VBZ cord-335975-m6lkrehi 2550 22 frequently frequently RB cord-335975-m6lkrehi 2550 23 fatal fatal JJ cord-335975-m6lkrehi 2550 24 . . . cord-335975-m6lkrehi 2551 1 This this DT cord-335975-m6lkrehi 2551 2 poisoning poisoning NN cord-335975-m6lkrehi 2551 3 is be VBZ cord-335975-m6lkrehi 2551 4 rare rare JJ cord-335975-m6lkrehi 2551 5 in in IN cord-335975-m6lkrehi 2551 6 France France NNP cord-335975-m6lkrehi 2551 7 , , , cord-335975-m6lkrehi 2551 8 but but CC cord-335975-m6lkrehi 2551 9 frequent frequent JJ cord-335975-m6lkrehi 2551 10 in in IN cord-335975-m6lkrehi 2551 11 the the DT cord-335975-m6lkrehi 2551 12 French french JJ cord-335975-m6lkrehi 2551 13 overseas overseas JJ cord-335975-m6lkrehi 2551 14 departments department NNS cord-335975-m6lkrehi 2551 15 ( ( -LRB- cord-335975-m6lkrehi 2551 16 DOM DOM NNP cord-335975-m6lkrehi 2551 17 ) ) -RRB- cord-335975-m6lkrehi 2551 18 . . . cord-335975-m6lkrehi 2552 1 The the DT cord-335975-m6lkrehi 2552 2 Rubigine Rubigine NNP cord-335975-m6lkrehi 2552 3 ® ® NN cord-335975-m6lkrehi 2552 4 , , , cord-335975-m6lkrehi 2552 5 made make VBN cord-335975-m6lkrehi 2552 6 of of IN cord-335975-m6lkrehi 2552 7 fluoride fluoride NN cord-335975-m6lkrehi 2552 8 and and CC cord-335975-m6lkrehi 2552 9 used use VBD cord-335975-m6lkrehi 2552 10 as as IN cord-335975-m6lkrehi 2552 11 a a DT cord-335975-m6lkrehi 2552 12 rust rust NN cord-335975-m6lkrehi 2552 13 remover remover NN cord-335975-m6lkrehi 2552 14 , , , cord-335975-m6lkrehi 2552 15 is be VBZ cord-335975-m6lkrehi 2552 16 the the DT cord-335975-m6lkrehi 2552 17 main main JJ cord-335975-m6lkrehi 2552 18 source source NN cord-335975-m6lkrehi 2552 19 of of IN cord-335975-m6lkrehi 2552 20 poisoning poisoning NN cord-335975-m6lkrehi 2552 21 in in IN cord-335975-m6lkrehi 2552 22 the the DT cord-335975-m6lkrehi 2552 23 Caribbean Caribbean NNP cord-335975-m6lkrehi 2552 24 . . . cord-335975-m6lkrehi 2553 1 In in IN cord-335975-m6lkrehi 2553 2 Martinique Martinique NNP cord-335975-m6lkrehi 2553 3 , , , cord-335975-m6lkrehi 2553 4 the the DT cord-335975-m6lkrehi 2553 5 exact exact JJ cord-335975-m6lkrehi 2553 6 incidence incidence NN cord-335975-m6lkrehi 2553 7 of of IN cord-335975-m6lkrehi 2553 8 this this DT cord-335975-m6lkrehi 2553 9 intoxication intoxication NN cord-335975-m6lkrehi 2553 10 is be VBZ cord-335975-m6lkrehi 2553 11 unknown unknown JJ cord-335975-m6lkrehi 2553 12 , , , cord-335975-m6lkrehi 2553 13 as as IN cord-335975-m6lkrehi 2553 14 there there EX cord-335975-m6lkrehi 2553 15 is be VBZ cord-335975-m6lkrehi 2553 16 no no DT cord-335975-m6lkrehi 2553 17 national national JJ cord-335975-m6lkrehi 2553 18 and and CC cord-335975-m6lkrehi 2553 19 regional regional JJ cord-335975-m6lkrehi 2553 20 register register NN cord-335975-m6lkrehi 2553 21 . . . cord-335975-m6lkrehi 2554 1 It -PRON- PRP cord-335975-m6lkrehi 2554 2 could could MD cord-335975-m6lkrehi 2554 3 represent represent VB cord-335975-m6lkrehi 2554 4 up up IN cord-335975-m6lkrehi 2554 5 to to TO cord-335975-m6lkrehi 2554 6 8 8 CD cord-335975-m6lkrehi 2554 7 - - SYM cord-335975-m6lkrehi 2554 8 10 10 CD cord-335975-m6lkrehi 2554 9 % % NN cord-335975-m6lkrehi 2554 10 of of IN cord-335975-m6lkrehi 2554 11 severe severe JJ cord-335975-m6lkrehi 2554 12 acute acute JJ cord-335975-m6lkrehi 2554 13 poisoning poisoning NN cord-335975-m6lkrehi 2554 14 . . . cord-335975-m6lkrehi 2555 1 It -PRON- PRP cord-335975-m6lkrehi 2555 2 was be VBD cord-335975-m6lkrehi 2555 3 not not RB cord-335975-m6lkrehi 2555 4 until until IN cord-335975-m6lkrehi 2555 5 April April NNP cord-335975-m6lkrehi 2555 6 1994 1994 CD cord-335975-m6lkrehi 2555 7 that that IN cord-335975-m6lkrehi 2555 8 , , , cord-335975-m6lkrehi 2555 9 following follow VBG cord-335975-m6lkrehi 2555 10 a a DT cord-335975-m6lkrehi 2555 11 prefectural prefectural JJ cord-335975-m6lkrehi 2555 12 order order NN cord-335975-m6lkrehi 2555 13 on on IN cord-335975-m6lkrehi 2555 14 the the DT cord-335975-m6lkrehi 2555 15 declaration declaration NN cord-335975-m6lkrehi 2555 16 , , , cord-335975-m6lkrehi 2555 17 classification classification NN cord-335975-m6lkrehi 2555 18 , , , cord-335975-m6lkrehi 2555 19 packaging packaging NN cord-335975-m6lkrehi 2555 20 and and CC cord-335975-m6lkrehi 2555 21 labeling labeling NN cord-335975-m6lkrehi 2555 22 of of IN cord-335975-m6lkrehi 2555 23 substances substance NNS cord-335975-m6lkrehi 2555 24 , , , cord-335975-m6lkrehi 2555 25 the the DT cord-335975-m6lkrehi 2555 26 composition composition NN cord-335975-m6lkrehi 2555 27 of of IN cord-335975-m6lkrehi 2555 28 Rubigine Rubigine NNP cord-335975-m6lkrehi 2555 29 ® ® NNP cord-335975-m6lkrehi 2555 30 was be VBD cord-335975-m6lkrehi 2555 31 modified modify VBN cord-335975-m6lkrehi 2555 32 to to TO cord-335975-m6lkrehi 2555 33 significantly significantly RB cord-335975-m6lkrehi 2555 34 reduce reduce VB cord-335975-m6lkrehi 2555 35 the the DT cord-335975-m6lkrehi 2555 36 mortality mortality NN cord-335975-m6lkrehi 2555 37 induced induce VBN cord-335975-m6lkrehi 2555 38 by by IN cord-335975-m6lkrehi 2555 39 its -PRON- PRP$ cord-335975-m6lkrehi 2555 40 ingestion ingestion NN cord-335975-m6lkrehi 2555 41 . . . cord-335975-m6lkrehi 2556 1 The the DT cord-335975-m6lkrehi 2556 2 objective objective NN cord-335975-m6lkrehi 2556 3 of of IN cord-335975-m6lkrehi 2556 4 our -PRON- PRP$ cord-335975-m6lkrehi 2556 5 study study NN cord-335975-m6lkrehi 2556 6 was be VBD cord-335975-m6lkrehi 2556 7 to to TO cord-335975-m6lkrehi 2556 8 describe describe VB cord-335975-m6lkrehi 2556 9 the the DT cord-335975-m6lkrehi 2556 10 clinical clinical JJ cord-335975-m6lkrehi 2556 11 features feature NNS cord-335975-m6lkrehi 2556 12 and and CC cord-335975-m6lkrehi 2556 13 complications complication NNS cord-335975-m6lkrehi 2556 14 that that WDT cord-335975-m6lkrehi 2556 15 can can MD cord-335975-m6lkrehi 2556 16 occur occur VB cord-335975-m6lkrehi 2556 17 after after IN cord-335975-m6lkrehi 2556 18 ingestion ingestion NN cord-335975-m6lkrehi 2556 19 of of IN cord-335975-m6lkrehi 2556 20 Rubigine Rubigine NNP cord-335975-m6lkrehi 2556 21 ® ® . cord-335975-m6lkrehi 2556 22 as as RB cord-335975-m6lkrehi 2556 23 well well RB cord-335975-m6lkrehi 2556 24 as as IN cord-335975-m6lkrehi 2556 25 to to TO cord-335975-m6lkrehi 2556 26 determine determine VB cord-335975-m6lkrehi 2556 27 the the DT cord-335975-m6lkrehi 2556 28 prognostic prognostic JJ cord-335975-m6lkrehi 2556 29 factors factor NNS cord-335975-m6lkrehi 2556 30 of of IN cord-335975-m6lkrehi 2556 31 death death NN cord-335975-m6lkrehi 2556 32 . . . cord-335975-m6lkrehi 2557 1 We -PRON- PRP cord-335975-m6lkrehi 2557 2 conducted conduct VBD cord-335975-m6lkrehi 2557 3 a a DT cord-335975-m6lkrehi 2557 4 retrospective retrospective JJ cord-335975-m6lkrehi 2557 5 study study NN cord-335975-m6lkrehi 2557 6 over over IN cord-335975-m6lkrehi 2557 7 16 16 CD cord-335975-m6lkrehi 2557 8 years year NNS cord-335975-m6lkrehi 2557 9 , , , cord-335975-m6lkrehi 2557 10 from from IN cord-335975-m6lkrehi 2557 11 2000 2000 CD cord-335975-m6lkrehi 2557 12 to to IN cord-335975-m6lkrehi 2557 13 2016 2016 CD cord-335975-m6lkrehi 2557 14 , , , cord-335975-m6lkrehi 2557 15 including include VBG cord-335975-m6lkrehi 2557 16 all all DT cord-335975-m6lkrehi 2557 17 patients patient NNS cord-335975-m6lkrehi 2557 18 admitted admit VBN cord-335975-m6lkrehi 2557 19 to to IN cord-335975-m6lkrehi 2557 20 emergency emergency NN cord-335975-m6lkrehi 2557 21 and and CC cord-335975-m6lkrehi 2557 22 intensive intensive JJ cord-335975-m6lkrehi 2557 23 care care NN cord-335975-m6lkrehi 2557 24 units unit NNS cord-335975-m6lkrehi 2557 25 of of IN cord-335975-m6lkrehi 2557 26 the the DT cord-335975-m6lkrehi 2557 27 University University NNP cord-335975-m6lkrehi 2557 28 Hospital Hospital NNP cord-335975-m6lkrehi 2557 29 Center Center NNP cord-335975-m6lkrehi 2557 30 ( ( -LRB- cord-335975-m6lkrehi 2557 31 Martinique Martinique NNP cord-335975-m6lkrehi 2557 32 ) ) -RRB- cord-335975-m6lkrehi 2557 33 for for IN cord-335975-m6lkrehi 2557 34 acute acute JJ cord-335975-m6lkrehi 2557 35 Rubigine Rubigine NNP cord-335975-m6lkrehi 2557 36 ® ® NN cord-335975-m6lkrehi 2557 37 poisoning poisoning NN cord-335975-m6lkrehi 2557 38 . . . cord-335975-m6lkrehi 2558 1 The the DT cord-335975-m6lkrehi 2558 2 usual usual JJ cord-335975-m6lkrehi 2558 3 demographic demographic JJ cord-335975-m6lkrehi 2558 4 and and CC cord-335975-m6lkrehi 2558 5 clinical clinical JJ cord-335975-m6lkrehi 2558 6 data datum NNS cord-335975-m6lkrehi 2558 7 were be VBD cord-335975-m6lkrehi 2558 8 collected collect VBN cord-335975-m6lkrehi 2558 9 and and CC cord-335975-m6lkrehi 2558 10 comparisons comparison NNS cord-335975-m6lkrehi 2558 11 between between IN cord-335975-m6lkrehi 2558 12 surviving survive VBG cord-335975-m6lkrehi 2558 13 and and CC cord-335975-m6lkrehi 2558 14 deceased deceased JJ cord-335975-m6lkrehi 2558 15 patients patient NNS cord-335975-m6lkrehi 2558 16 were be VBD cord-335975-m6lkrehi 2558 17 performed perform VBN cord-335975-m6lkrehi 2558 18 using use VBG cord-335975-m6lkrehi 2558 19 a a DT cord-335975-m6lkrehi 2558 20 univariate univariate JJ cord-335975-m6lkrehi 2558 21 analysis analysis NN cord-335975-m6lkrehi 2558 22 . . . cord-335975-m6lkrehi 2559 1 Results result NNS cord-335975-m6lkrehi 2559 2 : : : cord-335975-m6lkrehi 2560 1 Fifty fifty CD cord-335975-m6lkrehi 2560 2 - - HYPH cord-335975-m6lkrehi 2560 3 five five CD cord-335975-m6lkrehi 2560 4 patients patient NNS cord-335975-m6lkrehi 2560 5 ( ( -LRB- cord-335975-m6lkrehi 2560 6 mean mean VB cord-335975-m6lkrehi 2560 7 age-43 age-43 NNP cord-335975-m6lkrehi 2560 8 years year NNS cord-335975-m6lkrehi 2560 9 ( ( -LRB- cord-335975-m6lkrehi 2560 10 15 15 CD cord-335975-m6lkrehi 2560 11 - - SYM cord-335975-m6lkrehi 2560 12 82 82 CD cord-335975-m6lkrehi 2560 13 ) ) -RRB- cord-335975-m6lkrehi 2560 14 + + CC cord-335975-m6lkrehi 2560 15 sex sex NN cord-335975-m6lkrehi 2560 16 ratio ratio NN cord-335975-m6lkrehi 2560 17 male male NN cord-335975-m6lkrehi 2560 18 female-1,1 female-1,1 NNP cord-335975-m6lkrehi 2560 19 ) ) -RRB- cord-335975-m6lkrehi 2560 20 were be VBD cord-335975-m6lkrehi 2560 21 hospitalized hospitalize VBN cord-335975-m6lkrehi 2560 22 at at IN cord-335975-m6lkrehi 2560 23 the the DT cord-335975-m6lkrehi 2560 24 University University NNP cord-335975-m6lkrehi 2560 25 Hospital Hospital NNP cord-335975-m6lkrehi 2560 26 of of IN cord-335975-m6lkrehi 2560 27 Martinique Martinique NNP cord-335975-m6lkrehi 2560 28 . . . cord-335975-m6lkrehi 2561 1 One one CD cord-335975-m6lkrehi 2561 2 - - HYPH cord-335975-m6lkrehi 2561 3 quarter quarter NN cord-335975-m6lkrehi 2561 4 of of IN cord-335975-m6lkrehi 2561 5 patients patient NNS cord-335975-m6lkrehi 2561 6 had have VBD cord-335975-m6lkrehi 2561 7 no no DT cord-335975-m6lkrehi 2561 8 significant significant JJ cord-335975-m6lkrehi 2561 9 history history NN cord-335975-m6lkrehi 2561 10 . . . cord-335975-m6lkrehi 2562 1 The the DT cord-335975-m6lkrehi 2562 2 average average JJ cord-335975-m6lkrehi 2562 3 length length NN cord-335975-m6lkrehi 2562 4 of of IN cord-335975-m6lkrehi 2562 5 stay stay NN cord-335975-m6lkrehi 2562 6 was be VBD cord-335975-m6lkrehi 2562 7 3.3 3.3 CD cord-335975-m6lkrehi 2562 8 days day NNS cord-335975-m6lkrehi 2562 9 ( ( -LRB- cord-335975-m6lkrehi 2562 10 1 1 CD cord-335975-m6lkrehi 2562 11 - - SYM cord-335975-m6lkrehi 2562 12 37 37 CD cord-335975-m6lkrehi 2562 13 ) ) -RRB- cord-335975-m6lkrehi 2562 14 . . . cord-335975-m6lkrehi 2563 1 Forty forty CD cord-335975-m6lkrehi 2563 2 percent percent NN cord-335975-m6lkrehi 2563 3 of of IN cord-335975-m6lkrehi 2563 4 patients patient NNS cord-335975-m6lkrehi 2563 5 experienced experience VBD cord-335975-m6lkrehi 2563 6 hypocalcaemia hypocalcaemia NN cord-335975-m6lkrehi 2563 7 after after IN cord-335975-m6lkrehi 2563 8 initial initial JJ cord-335975-m6lkrehi 2563 9 intravenous intravenous JJ cord-335975-m6lkrehi 2563 10 calcium calcium NN cord-335975-m6lkrehi 2563 11 supplementation supplementation NN cord-335975-m6lkrehi 2563 12 . . . cord-335975-m6lkrehi 2564 1 Complications complication NNS cord-335975-m6lkrehi 2564 2 included include VBD cord-335975-m6lkrehi 2564 3 acute acute JJ cord-335975-m6lkrehi 2564 4 respiratory respiratory JJ cord-335975-m6lkrehi 2564 5 failure failure NN cord-335975-m6lkrehi 2564 6 requiring require VBG cord-335975-m6lkrehi 2564 7 invasive invasive JJ cord-335975-m6lkrehi 2564 8 mechanical mechanical JJ cord-335975-m6lkrehi 2564 9 ventilation ventilation NN cord-335975-m6lkrehi 2564 10 ( ( -LRB- cord-335975-m6lkrehi 2564 11 22 22 CD cord-335975-m6lkrehi 2564 12 % % NN cord-335975-m6lkrehi 2564 13 of of IN cord-335975-m6lkrehi 2564 14 patients patient NNS cord-335975-m6lkrehi 2564 15 , , , cord-335975-m6lkrehi 2564 16 duration duration NN cord-335975-m6lkrehi 2564 17 of of IN cord-335975-m6lkrehi 2564 18 ventilation-2.8 ventilation-2.8 NN cord-335975-m6lkrehi 2564 19 days day NNS cord-335975-m6lkrehi 2564 20 , , , cord-335975-m6lkrehi 2564 21 ( ( -LRB- cord-335975-m6lkrehi 2564 22 1 1 CD cord-335975-m6lkrehi 2564 23 - - SYM cord-335975-m6lkrehi 2564 24 16 16 CD cord-335975-m6lkrehi 2564 25 ) ) -RRB- cord-335975-m6lkrehi 2564 26 ) ) -RRB- cord-335975-m6lkrehi 2564 27 , , , cord-335975-m6lkrehi 2564 28 renal renal JJ cord-335975-m6lkrehi 2564 29 failure failure NN cord-335975-m6lkrehi 2564 30 ( ( -LRB- cord-335975-m6lkrehi 2564 31 20 20 CD cord-335975-m6lkrehi 2564 32 % % NN cord-335975-m6lkrehi 2564 33 , , , cord-335975-m6lkrehi 2564 34 of of IN cord-335975-m6lkrehi 2564 35 which which WDT cord-335975-m6lkrehi 2564 36 50 50 CD cord-335975-m6lkrehi 2564 37 % % NN cord-335975-m6lkrehi 2564 38 required require VBN cord-335975-m6lkrehi 2564 39 extrarenal extrarenal JJ cord-335975-m6lkrehi 2564 40 treatment treatment NN cord-335975-m6lkrehi 2564 41 , , , cord-335975-m6lkrehi 2564 42 hemodynamic hemodynamic JJ cord-335975-m6lkrehi 2564 43 failure failure NN cord-335975-m6lkrehi 2564 44 ( ( -LRB- cord-335975-m6lkrehi 2564 45 16 16 CD cord-335975-m6lkrehi 2564 46 % % NN cord-335975-m6lkrehi 2564 47 ) ) -RRB- cord-335975-m6lkrehi 2564 48 , , , cord-335975-m6lkrehi 2564 49 hepatic hepatic JJ cord-335975-m6lkrehi 2564 50 failure failure NN cord-335975-m6lkrehi 2564 51 ( ( -LRB- cord-335975-m6lkrehi 2564 52 15 15 CD cord-335975-m6lkrehi 2564 53 % % NN cord-335975-m6lkrehi 2564 54 ) ) -RRB- cord-335975-m6lkrehi 2564 55 , , , cord-335975-m6lkrehi 2564 56 coagulation coagulation NN cord-335975-m6lkrehi 2564 57 failure failure NN cord-335975-m6lkrehi 2564 58 ( ( -LRB- cord-335975-m6lkrehi 2564 59 15 15 CD cord-335975-m6lkrehi 2564 60 % % NN cord-335975-m6lkrehi 2564 61 ) ) -RRB- cord-335975-m6lkrehi 2564 62 , , , cord-335975-m6lkrehi 2564 63 neurological neurological JJ cord-335975-m6lkrehi 2564 64 failure failure NN cord-335975-m6lkrehi 2564 65 ( ( -LRB- cord-335975-m6lkrehi 2564 66 12 12 CD cord-335975-m6lkrehi 2564 67 % % NN cord-335975-m6lkrehi 2564 68 ) ) -RRB- cord-335975-m6lkrehi 2564 69 and and CC cord-335975-m6lkrehi 2564 70 multi multi JJ cord-335975-m6lkrehi 2564 71 - - JJ cord-335975-m6lkrehi 2564 72 visceral visceral JJ cord-335975-m6lkrehi 2564 73 failure failure NN cord-335975-m6lkrehi 2564 74 ( ( -LRB- cord-335975-m6lkrehi 2564 75 10.9 10.9 CD cord-335975-m6lkrehi 2564 76 % % NN cord-335975-m6lkrehi 2564 77 ) ) -RRB- cord-335975-m6lkrehi 2564 78 . . . cord-335975-m6lkrehi 2565 1 Three three CD cord-335975-m6lkrehi 2565 2 patients patient NNS cord-335975-m6lkrehi 2565 3 presented present VBD cord-335975-m6lkrehi 2565 4 cardiogenic cardiogenic JJ cord-335975-m6lkrehi 2565 5 refractory refractory JJ cord-335975-m6lkrehi 2565 6 shock shock NN cord-335975-m6lkrehi 2565 7 requiring require VBG cord-335975-m6lkrehi 2565 8 VA VA NNP cord-335975-m6lkrehi 2565 9 ECMO ECMO NNP cord-335975-m6lkrehi 2565 10 ( ( -LRB- cord-335975-m6lkrehi 2565 11 5.5 5.5 CD cord-335975-m6lkrehi 2565 12 % % NN cord-335975-m6lkrehi 2565 13 ) ) -RRB- cord-335975-m6lkrehi 2565 14 and and CC cord-335975-m6lkrehi 2565 15 another another DT cord-335975-m6lkrehi 2565 16 patient patient NN cord-335975-m6lkrehi 2565 17 with with IN cord-335975-m6lkrehi 2565 18 digestive digestive JJ cord-335975-m6lkrehi 2565 19 perforation perforation NN cord-335975-m6lkrehi 2565 20 ( ( -LRB- cord-335975-m6lkrehi 2565 21 1.8 1.8 CD cord-335975-m6lkrehi 2565 22 % % NN cord-335975-m6lkrehi 2565 23 ) ) -RRB- cord-335975-m6lkrehi 2565 24 . . . cord-335975-m6lkrehi 2566 1 The the DT cord-335975-m6lkrehi 2566 2 mortality mortality NN cord-335975-m6lkrehi 2566 3 was be VBD cord-335975-m6lkrehi 2566 4 10.9 10.9 CD cord-335975-m6lkrehi 2566 5 % % NN cord-335975-m6lkrehi 2566 6 , , , cord-335975-m6lkrehi 2566 7 allowing allow VBG cord-335975-m6lkrehi 2566 8 the the DT cord-335975-m6lkrehi 2566 9 identification identification NN cord-335975-m6lkrehi 2566 10 of of IN cord-335975-m6lkrehi 2566 11 prognostic prognostic JJ cord-335975-m6lkrehi 2566 12 factors factor NNS cord-335975-m6lkrehi 2566 13 of of IN cord-335975-m6lkrehi 2566 14 death death NN cord-335975-m6lkrehi 2566 15 . . . cord-335975-m6lkrehi 2567 1 Conclusion conclusion NN cord-335975-m6lkrehi 2567 2 : : : cord-335975-m6lkrehi 2568 1 Rubigine Rubigine NNP cord-335975-m6lkrehi 2568 2 ® ® IN cord-335975-m6lkrehi 2568 3 poisoning poisoning NN cord-335975-m6lkrehi 2568 4 is be VBZ cord-335975-m6lkrehi 2568 5 responsible responsible JJ cord-335975-m6lkrehi 2568 6 for for IN cord-335975-m6lkrehi 2568 7 significant significant JJ cord-335975-m6lkrehi 2568 8 morbidity morbidity NN cord-335975-m6lkrehi 2568 9 and and CC cord-335975-m6lkrehi 2568 10 mortality mortality NN cord-335975-m6lkrehi 2568 11 , , , cord-335975-m6lkrehi 2568 12 despite despite IN cord-335975-m6lkrehi 2568 13 optimal optimal JJ cord-335975-m6lkrehi 2568 14 management management NN cord-335975-m6lkrehi 2568 15 . . . cord-335975-m6lkrehi 2569 1 However however RB cord-335975-m6lkrehi 2569 2 , , , cord-335975-m6lkrehi 2569 3 its -PRON- PRP$ cord-335975-m6lkrehi 2569 4 incidence incidence NN cord-335975-m6lkrehi 2569 5 seems seem VBZ cord-335975-m6lkrehi 2569 6 to to TO cord-335975-m6lkrehi 2569 7 have have VB cord-335975-m6lkrehi 2569 8 decreased decrease VBN cord-335975-m6lkrehi 2569 9 sharply sharply RB cord-335975-m6lkrehi 2569 10 in in IN cord-335975-m6lkrehi 2569 11 recent recent JJ cord-335975-m6lkrehi 2569 12 years year NNS cord-335975-m6lkrehi 2569 13 thanks thank NNS cord-335975-m6lkrehi 2569 14 to to IN cord-335975-m6lkrehi 2569 15 the the DT cord-335975-m6lkrehi 2569 16 strong strong JJ cord-335975-m6lkrehi 2569 17 mobilization mobilization NN cord-335975-m6lkrehi 2569 18 and and CC cord-335975-m6lkrehi 2569 19 awareness awareness NN cord-335975-m6lkrehi 2569 20 of of IN cord-335975-m6lkrehi 2569 21 the the DT cord-335975-m6lkrehi 2569 22 population population NN cord-335975-m6lkrehi 2569 23 following follow VBG cord-335975-m6lkrehi 2569 24 the the DT cord-335975-m6lkrehi 2569 25 implementation implementation NN cord-335975-m6lkrehi 2569 26 of of IN cord-335975-m6lkrehi 2569 27 an an DT cord-335975-m6lkrehi 2569 28 information information NN cord-335975-m6lkrehi 2569 29 system system NN cord-335975-m6lkrehi 2569 30 by by IN cord-335975-m6lkrehi 2569 31 the the DT cord-335975-m6lkrehi 2569 32 University University NNP cord-335975-m6lkrehi 2569 33 Hospital Hospital NNP cord-335975-m6lkrehi 2569 34 's 's POS cord-335975-m6lkrehi 2569 35 clinical clinical JJ cord-335975-m6lkrehi 2569 36 toxicology toxicology NN cord-335975-m6lkrehi 2569 37 and and CC cord-335975-m6lkrehi 2569 38 toxico toxico NN cord-335975-m6lkrehi 2569 39 - - HYPH cord-335975-m6lkrehi 2569 40 vigilance vigilance NN cord-335975-m6lkrehi 2569 41 unit unit NN cord-335975-m6lkrehi 2569 42 , , , cord-335975-m6lkrehi 2569 43 and and CC cord-335975-m6lkrehi 2569 44 different different JJ cord-335975-m6lkrehi 2569 45 preventive preventive JJ cord-335975-m6lkrehi 2569 46 measures measure NNS cord-335975-m6lkrehi 2569 47 introduced introduce VBN cord-335975-m6lkrehi 2569 48 by by IN cord-335975-m6lkrehi 2569 49 the the DT cord-335975-m6lkrehi 2569 50 health health NN cord-335975-m6lkrehi 2569 51 authorities authority NNS cord-335975-m6lkrehi 2569 52 . . . cord-335975-m6lkrehi 2570 1 Introduction introduction NN cord-335975-m6lkrehi 2570 2 : : : cord-335975-m6lkrehi 2571 1 Since since IN cord-335975-m6lkrehi 2571 2 dextropropoxyphene dextropropoxyphene NN cord-335975-m6lkrehi 2571 3 withdrawal withdrawal NN cord-335975-m6lkrehi 2571 4 from from IN cord-335975-m6lkrehi 2571 5 the the DT cord-335975-m6lkrehi 2571 6 market market NN cord-335975-m6lkrehi 2571 7 , , , cord-335975-m6lkrehi 2571 8 overdoses overdose NNS cord-335975-m6lkrehi 2571 9 and and CC cord-335975-m6lkrehi 2571 10 fatalities fatality NNS cord-335975-m6lkrehi 2571 11 attributed attribute VBN cord-335975-m6lkrehi 2571 12 to to IN cord-335975-m6lkrehi 2571 13 tramadol tramadol NN cord-335975-m6lkrehi 2571 14 , , , cord-335975-m6lkrehi 2571 15 a a DT cord-335975-m6lkrehi 2571 16 WHO WHO NNP cord-335975-m6lkrehi 2571 17 step-2 step-2 NNP cord-335975-m6lkrehi 2571 18 opioid opioid JJ cord-335975-m6lkrehi 2571 19 analgesic analgesic JJ cord-335975-m6lkrehi 2571 20 drug drug NN cord-335975-m6lkrehi 2571 21 , , , cord-335975-m6lkrehi 2571 22 have have VBP cord-335975-m6lkrehi 2571 23 increased increase VBN cord-335975-m6lkrehi 2571 24 markedly markedly RB cord-335975-m6lkrehi 2571 25 . . . cord-335975-m6lkrehi 2572 1 Besides besides IN cord-335975-m6lkrehi 2572 2 central central JJ cord-335975-m6lkrehi 2572 3 nervous nervous JJ cord-335975-m6lkrehi 2572 4 system system NN cord-335975-m6lkrehi 2572 5 depression depression NN cord-335975-m6lkrehi 2572 6 , , , cord-335975-m6lkrehi 2572 7 tramadol tramadol NN cord-335975-m6lkrehi 2572 8 overdose overdose NN cord-335975-m6lkrehi 2572 9 may may MD cord-335975-m6lkrehi 2572 10 result result VB cord-335975-m6lkrehi 2572 11 in in IN cord-335975-m6lkrehi 2572 12 seizures seizure NNS cord-335975-m6lkrehi 2572 13 , , , cord-335975-m6lkrehi 2572 14 usually usually RB cord-335975-m6lkrehi 2572 15 included include VBN cord-335975-m6lkrehi 2572 16 in in IN cord-335975-m6lkrehi 2572 17 the the DT cord-335975-m6lkrehi 2572 18 related relate VBN cord-335975-m6lkrehi 2572 19 serotonin serotonin NN cord-335975-m6lkrehi 2572 20 syndrome syndrome NN cord-335975-m6lkrehi 2572 21 . . . cord-335975-m6lkrehi 2573 1 However however RB cord-335975-m6lkrehi 2573 2 , , , cord-335975-m6lkrehi 2573 3 the the DT cord-335975-m6lkrehi 2573 4 serotoninergic serotoninergic JJ cord-335975-m6lkrehi 2573 5 mechanism mechanism NN cord-335975-m6lkrehi 2573 6 of of IN cord-335975-m6lkrehi 2573 7 tramadol tramadol NN cord-335975-m6lkrehi 2573 8 - - HYPH cord-335975-m6lkrehi 2573 9 induced induce VBN cord-335975-m6lkrehi 2573 10 seizures seizure NNS cord-335975-m6lkrehi 2573 11 has have VBZ cord-335975-m6lkrehi 2573 12 been be VBN cord-335975-m6lkrehi 2573 13 recently recently RB cord-335975-m6lkrehi 2573 14 questioned question VBN cord-335975-m6lkrehi 2573 15 . . . cord-335975-m6lkrehi 2574 1 We -PRON- PRP cord-335975-m6lkrehi 2574 2 investigated investigate VBD cord-335975-m6lkrehi 2574 3 the the DT cord-335975-m6lkrehi 2574 4 effects effect NNS cord-335975-m6lkrehi 2574 5 of of IN cord-335975-m6lkrehi 2574 6 various various JJ cord-335975-m6lkrehi 2574 7 specific specific JJ cord-335975-m6lkrehi 2574 8 pretreatments pretreatment NNS cord-335975-m6lkrehi 2574 9 on on IN cord-335975-m6lkrehi 2574 10 tramadol tramadol NN cord-335975-m6lkrehi 2574 11 - - HYPH cord-335975-m6lkrehi 2574 12 induced induce VBN cord-335975-m6lkrehi 2574 13 seizure seizure NN cord-335975-m6lkrehi 2574 14 onset onset NN cord-335975-m6lkrehi 2574 15 and and CC cord-335975-m6lkrehi 2574 16 alterations alteration NNS cord-335975-m6lkrehi 2574 17 in in IN cord-335975-m6lkrehi 2574 18 brain brain NN cord-335975-m6lkrehi 2574 19 monoamines monoamine NNS cord-335975-m6lkrehi 2574 20 in in IN cord-335975-m6lkrehi 2574 21 the the DT cord-335975-m6lkrehi 2574 22 rat rat NN cord-335975-m6lkrehi 2574 23 . . . cord-335975-m6lkrehi 2575 1 Patients patient NNS cord-335975-m6lkrehi 2575 2 and and CC cord-335975-m6lkrehi 2575 3 methods method NNS cord-335975-m6lkrehi 2575 4 : : : cord-335975-m6lkrehi 2575 5 Sprague Sprague NNP cord-335975-m6lkrehi 2575 6 - - HYPH cord-335975-m6lkrehi 2575 7 Dawley Dawley NNP cord-335975-m6lkrehi 2575 8 rats rat NNS cord-335975-m6lkrehi 2575 9 were be VBD cord-335975-m6lkrehi 2575 10 randomized randomize VBN cord-335975-m6lkrehi 2575 11 into into IN cord-335975-m6lkrehi 2575 12 five five CD cord-335975-m6lkrehi 2575 13 groups group NNS cord-335975-m6lkrehi 2575 14 ( ( -LRB- cord-335975-m6lkrehi 2575 15 N n NN cord-335975-m6lkrehi 2575 16 = = SYM cord-335975-m6lkrehi 2575 17 6 6 CD cord-335975-m6lkrehi 2575 18 group group NN cord-335975-m6lkrehi 2575 19 ) ) -RRB- cord-335975-m6lkrehi 2575 20 to to TO cord-335975-m6lkrehi 2575 21 be be VB cord-335975-m6lkrehi 2575 22 pretreated pretreate VBN cord-335975-m6lkrehi 2575 23 with with IN cord-335975-m6lkrehi 2575 24 various various JJ cord-335975-m6lkrehi 2575 25 agonists agonist NNS cord-335975-m6lkrehi 2575 26 antagonists antagonist NNS cord-335975-m6lkrehi 2575 27 before before IN cord-335975-m6lkrehi 2575 28 receiving receive VBG cord-335975-m6lkrehi 2575 29 75 75 CD cord-335975-m6lkrehi 2575 30 mg mg NNP cord-335975-m6lkrehi 2575 31 kg kg NN cord-335975-m6lkrehi 2575 32 tramadol tramadol NN cord-335975-m6lkrehi 2575 33 intraperitoneally-1.77 intraperitoneally-1.77 IN cord-335975-m6lkrehi 2576 1 mg mg NNP cord-335975-m6lkrehi 2576 2 kg kg NNP cord-335975-m6lkrehi 2576 3 IP ip NN cord-335975-m6lkrehi 2576 4 diazepam diazepam NN cord-335975-m6lkrehi 2576 5 + + . cord-335975-m6lkrehi 2577 1 2 2 CD cord-335975-m6lkrehi 2577 2 mg mg NNP cord-335975-m6lkrehi 2577 3 kg kg NNP cord-335975-m6lkrehi 2578 1 IV IV NNP cord-335975-m6lkrehi 2578 2 bolus bolus NN cord-335975-m6lkrehi 2578 3 followed follow VBD cord-335975-m6lkrehi 2578 4 by by IN cord-335975-m6lkrehi 2578 5 4 4 CD cord-335975-m6lkrehi 2578 6 mg mg NNP cord-335975-m6lkrehi 2578 7 kg kg NNP cord-335975-m6lkrehi 2578 8 h h NN cord-335975-m6lkrehi 2578 9 infusion infusion NN cord-335975-m6lkrehi 2578 10 naloxone naloxone NN cord-335975-m6lkrehi 2578 11 + + SYM cord-335975-m6lkrehi 2578 12 10 10 CD cord-335975-m6lkrehi 2578 13 mg mg NNP cord-335975-m6lkrehi 2578 14 kg kg NNP cord-335975-m6lkrehi 2578 15 IP ip NN cord-335975-m6lkrehi 2578 16 cyproheptadine cyproheptadine NN cord-335975-m6lkrehi 2578 17 , , , cord-335975-m6lkrehi 2578 18 and and CC cord-335975-m6lkrehi 2578 19 15 15 CD cord-335975-m6lkrehi 2578 20 mg mg NN cord-335975-m6lkrehi 2578 21 kg kg NNP cord-335975-m6lkrehi 2578 22 IP ip NN cord-335975-m6lkrehi 2578 23 fexofenadine fexofenadine NN cord-335975-m6lkrehi 2578 24 . . . cord-335975-m6lkrehi 2579 1 Seizure seizure NN cord-335975-m6lkrehi 2579 2 severity severity NN cord-335975-m6lkrehi 2579 3 was be VBD cord-335975-m6lkrehi 2579 4 graded grade VBN cord-335975-m6lkrehi 2579 5 according accord VBG cord-335975-m6lkrehi 2579 6 to to IN cord-335975-m6lkrehi 2579 7 the the DT cord-335975-m6lkrehi 2579 8 modified modify VBN cord-335975-m6lkrehi 2579 9 Racine Racine NNP cord-335975-m6lkrehi 2579 10 Score Score NNP cord-335975-m6lkrehi 2579 11 ( ( -LRB- cord-335975-m6lkrehi 2579 12 1 1 CD cord-335975-m6lkrehi 2579 13 ) ) -RRB- cord-335975-m6lkrehi 2579 14 . . . cord-335975-m6lkrehi 2580 1 We -PRON- PRP cord-335975-m6lkrehi 2580 2 measured measure VBD cord-335975-m6lkrehi 2580 3 neurotransmitter neurotransmitter NN cord-335975-m6lkrehi 2580 4 concentrations concentration NNS cord-335975-m6lkrehi 2580 5 in in IN cord-335975-m6lkrehi 2580 6 the the DT cord-335975-m6lkrehi 2580 7 frontal frontal JJ cord-335975-m6lkrehi 2580 8 cortex cortex NN cord-335975-m6lkrehi 2580 9 using use VBG cord-335975-m6lkrehi 2580 10 high high JJ cord-335975-m6lkrehi 2580 11 performance performance NN cord-335975-m6lkrehi 2580 12 liquid liquid NN cord-335975-m6lkrehi 2580 13 chromatography chromatography NN cord-335975-m6lkrehi 2580 14 coupled couple VBN cord-335975-m6lkrehi 2580 15 to to IN cord-335975-m6lkrehi 2580 16 flurorimetry flurorimetry NNP cord-335975-m6lkrehi 2580 17 or or CC cord-335975-m6lkrehi 2580 18 radioenzymatic radioenzymatic JJ cord-335975-m6lkrehi 2580 19 assay assay NN cord-335975-m6lkrehi 2580 20 , , , cord-335975-m6lkrehi 2580 21 as as IN cord-335975-m6lkrehi 2580 22 required require VBN cord-335975-m6lkrehi 2580 23 . . . cord-335975-m6lkrehi 2581 1 We -PRON- PRP cord-335975-m6lkrehi 2581 2 used use VBD cord-335975-m6lkrehi 2581 3 positron positron NN cord-335975-m6lkrehi 2581 4 emission emission NN cord-335975-m6lkrehi 2581 5 tomography tomography NN cord-335975-m6lkrehi 2581 6 - - HYPH cord-335975-m6lkrehi 2581 7 computed compute VBN cord-335975-m6lkrehi 2581 8 tomography tomography NN cord-335975-m6lkrehi 2581 9 to to TO cord-335975-m6lkrehi 2581 10 investigate investigate VB cord-335975-m6lkrehi 2581 11 Interactions interaction NNS cord-335975-m6lkrehi 2581 12 of of IN cord-335975-m6lkrehi 2581 13 tramadol tramadol NN cord-335975-m6lkrehi 2581 14 with with IN cord-335975-m6lkrehi 2581 15 GABA GABA NNP cord-335975-m6lkrehi 2581 16 - - HYPH cord-335975-m6lkrehi 2581 17 A A NNP cord-335975-m6lkrehi 2581 18 receptors receptor NNS cord-335975-m6lkrehi 2581 19 . . . cord-335975-m6lkrehi 2582 1 The the DT cord-335975-m6lkrehi 2582 2 effects effect NNS cord-335975-m6lkrehi 2582 3 of of IN cord-335975-m6lkrehi 2582 4 treatments treatment NNS cord-335975-m6lkrehi 2582 5 on on IN cord-335975-m6lkrehi 2582 6 seizures seizure NNS cord-335975-m6lkrehi 2582 7 were be VBD cord-335975-m6lkrehi 2582 8 compared compare VBN cord-335975-m6lkrehi 2582 9 using use VBG cord-335975-m6lkrehi 2582 10 two two CD cord-335975-m6lkrehi 2582 11 - - HYPH cord-335975-m6lkrehi 2582 12 way way NN cord-335975-m6lkrehi 2582 13 analysis analysis NN cord-335975-m6lkrehi 2582 14 of of IN cord-335975-m6lkrehi 2582 15 variance variance NN cord-335975-m6lkrehi 2582 16 followed follow VBN cord-335975-m6lkrehi 2582 17 by by IN cord-335975-m6lkrehi 2582 18 multiple multiple JJ cord-335975-m6lkrehi 2582 19 comparison comparison NN cord-335975-m6lkrehi 2582 20 tests test NNS cord-335975-m6lkrehi 2582 21 with with IN cord-335975-m6lkrehi 2582 22 Bonferroni Bonferroni NNP cord-335975-m6lkrehi 2582 23 's 's POS cord-335975-m6lkrehi 2582 24 correction correction NN cord-335975-m6lkrehi 2582 25 . . . cord-335975-m6lkrehi 2583 1 The the DT cord-335975-m6lkrehi 2583 2 Areas area NNS cord-335975-m6lkrehi 2583 3 under under IN cord-335975-m6lkrehi 2583 4 the the DT cord-335975-m6lkrehi 2583 5 curves curve NNS cord-335975-m6lkrehi 2583 6 of of IN cord-335975-m6lkrehi 2583 7 the the DT cord-335975-m6lkrehi 2583 8 effects effect NNS cord-335975-m6lkrehi 2583 9 on on IN cord-335975-m6lkrehi 2583 10 monoamine monoamine NN cord-335975-m6lkrehi 2583 11 concentrations concentration NNS cord-335975-m6lkrehi 2583 12 and and CC cord-335975-m6lkrehi 2583 13 the the DT cord-335975-m6lkrehi 2583 14 binding bind VBG cord-335975-m6lkrehi 2583 15 potentials potential NNS cord-335975-m6lkrehi 2583 16 in in IN cord-335975-m6lkrehi 2583 17 the the DT cord-335975-m6lkrehi 2583 18 PET pet NN cord-335975-m6lkrehi 2583 19 - - HYPH cord-335975-m6lkrehi 2583 20 imaging imaging NN cord-335975-m6lkrehi 2583 21 study study NN cord-335975-m6lkrehi 2583 22 were be VBD cord-335975-m6lkrehi 2583 23 compared compare VBN cord-335975-m6lkrehi 2583 24 two two CD cord-335975-m6lkrehi 2583 25 - - HYPH cord-335975-m6lkrehi 2583 26 by by IN cord-335975-m6lkrehi 2583 27 - - HYPH cord-335975-m6lkrehi 2583 28 two two CD cord-335975-m6lkrehi 2583 29 using use VBG cord-335975-m6lkrehi 2583 30 Mann Mann NNP cord-335975-m6lkrehi 2583 31 - - HYPH cord-335975-m6lkrehi 2583 32 Whitney Whitney NNP cord-335975-m6lkrehi 2583 33 U U NNP cord-335975-m6lkrehi 2583 34 tests test VBZ cord-335975-m6lkrehi 2583 35 . . . cord-335975-m6lkrehi 2584 1 Results result NNS cord-335975-m6lkrehi 2584 2 : : : cord-335975-m6lkrehi 2585 1 Diazepam diazepam NN cord-335975-m6lkrehi 2585 2 abolished abolish VBN cord-335975-m6lkrehi 2585 3 tramadol tramadol NN cord-335975-m6lkrehi 2585 4 - - HYPH cord-335975-m6lkrehi 2585 5 induced induce VBN cord-335975-m6lkrehi 2585 6 seizures seizure NNS cord-335975-m6lkrehi 2585 7 , , , cord-335975-m6lkrehi 2585 8 by by IN cord-335975-m6lkrehi 2585 9 contrast contrast NN cord-335975-m6lkrehi 2585 10 to to IN cord-335975-m6lkrehi 2585 11 naloxone naloxone NN cord-335975-m6lkrehi 2585 12 , , , cord-335975-m6lkrehi 2585 13 cyproheptadine cyproheptadine NNP cord-335975-m6lkrehi 2585 14 and and CC cord-335975-m6lkrehi 2585 15 fexofenadine fexofenadine NNP cord-335975-m6lkrehi 2585 16 pretreatments pretreatments NNP cord-335975-m6lkrehi 2585 17 . . . cord-335975-m6lkrehi 2586 1 Interestingly interestingly RB cord-335975-m6lkrehi 2586 2 , , , cord-335975-m6lkrehi 2586 3 despite despite IN cord-335975-m6lkrehi 2586 4 seizure seizure NN cord-335975-m6lkrehi 2586 5 abolishment abolishment NN cord-335975-m6lkrehi 2586 6 , , , cord-335975-m6lkrehi 2586 7 diazepam diazepam NN cord-335975-m6lkrehi 2586 8 significantly significantly RB cord-335975-m6lkrehi 2586 9 enhanced enhance VBN cord-335975-m6lkrehi 2586 10 tramadol tramadol NN cord-335975-m6lkrehi 2586 11 - - HYPH cord-335975-m6lkrehi 2586 12 induced induce VBN cord-335975-m6lkrehi 2586 13 increase increase NN cord-335975-m6lkrehi 2586 14 in in IN cord-335975-m6lkrehi 2586 15 the the DT cord-335975-m6lkrehi 2586 16 brain brain NN cord-335975-m6lkrehi 2586 17 serotonin serotonin NN cord-335975-m6lkrehi 2586 18 ( ( -LRB- cord-335975-m6lkrehi 2586 19 p p NN cord-335975-m6lkrehi 2586 20 < < XX cord-335975-m6lkrehi 2586 21 0.01 0.01 CD cord-335975-m6lkrehi 2586 22 ) ) -RRB- cord-335975-m6lkrehi 2586 23 , , , cord-335975-m6lkrehi 2586 24 histamine histamine NN cord-335975-m6lkrehi 2586 25 ( ( -LRB- cord-335975-m6lkrehi 2586 26 p p NN cord-335975-m6lkrehi 2586 27 < < XX cord-335975-m6lkrehi 2586 28 0.01 0.01 CD cord-335975-m6lkrehi 2586 29 ) ) -RRB- cord-335975-m6lkrehi 2586 30 , , , cord-335975-m6lkrehi 2586 31 dopamine dopamine NN cord-335975-m6lkrehi 2586 32 ( ( -LRB- cord-335975-m6lkrehi 2586 33 p p NN cord-335975-m6lkrehi 2586 34 < < XX cord-335975-m6lkrehi 2586 35 0.05 0.05 CD cord-335975-m6lkrehi 2586 36 ) ) -RRB- cord-335975-m6lkrehi 2586 37 and and CC cord-335975-m6lkrehi 2586 38 norepinephrine norepinephrine NN cord-335975-m6lkrehi 2586 39 ( ( -LRB- cord-335975-m6lkrehi 2586 40 p p NN cord-335975-m6lkrehi 2586 41 < < XX cord-335975-m6lkrehi 2586 42 0.05 0.05 CD cord-335975-m6lkrehi 2586 43 ) ) -RRB- cord-335975-m6lkrehi 2586 44 while while IN cord-335975-m6lkrehi 2586 45 no no DT cord-335975-m6lkrehi 2586 46 significant significant JJ cord-335975-m6lkrehi 2586 47 modifications modification NNS cord-335975-m6lkrehi 2586 48 were be VBD cord-335975-m6lkrehi 2586 49 observed observe VBN cord-335975-m6lkrehi 2586 50 with with IN cord-335975-m6lkrehi 2586 51 the the DT cord-335975-m6lkrehi 2586 52 other other JJ cord-335975-m6lkrehi 2586 53 tested test VBN cord-335975-m6lkrehi 2586 54 pretreatments pretreatment NNS cord-335975-m6lkrehi 2586 55 . . . cord-335975-m6lkrehi 2587 1 Based base VBN cord-335975-m6lkrehi 2587 2 on on IN cord-335975-m6lkrehi 2587 3 Positron Positron NNP cord-335975-m6lkrehi 2587 4 emission emission NN cord-335975-m6lkrehi 2587 5 tomography tomography NN cord-335975-m6lkrehi 2587 6 imaging imaging NN cord-335975-m6lkrehi 2587 7 using use VBG cord-335975-m6lkrehi 2587 8 11C 11c NN cord-335975-m6lkrehi 2587 9 - - HYPH cord-335975-m6lkrehi 2587 10 flumazenil flumazenil NN cord-335975-m6lkrehi 2587 11 fixation fixation NN cord-335975-m6lkrehi 2587 12 in in IN cord-335975-m6lkrehi 2587 13 the the DT cord-335975-m6lkrehi 2587 14 rat rat NN cord-335975-m6lkrehi 2587 15 brain brain NN cord-335975-m6lkrehi 2587 16 , , , cord-335975-m6lkrehi 2587 17 we -PRON- PRP cord-335975-m6lkrehi 2587 18 demonstrated demonstrate VBD cord-335975-m6lkrehi 2587 19 molecular molecular JJ cord-335975-m6lkrehi 2587 20 interaction interaction NN cord-335975-m6lkrehi 2587 21 between between IN cord-335975-m6lkrehi 2587 22 tramadol tramadol NN cord-335975-m6lkrehi 2587 23 and and CC cord-335975-m6lkrehi 2587 24 γ γ NN cord-335975-m6lkrehi 2587 25 - - HYPH cord-335975-m6lkrehi 2587 26 aminobutyric aminobutyric NN cord-335975-m6lkrehi 2587 27 acid acid NN cord-335975-m6lkrehi 2587 28 ( ( -LRB- cord-335975-m6lkrehi 2587 29 GABA)-A GABA)-A NNP cord-335975-m6lkrehi 2587 30 receptors receptor NNS cord-335975-m6lkrehi 2587 31 not not RB cord-335975-m6lkrehi 2587 32 related relate VBN cord-335975-m6lkrehi 2587 33 to to IN cord-335975-m6lkrehi 2587 34 a a DT cord-335975-m6lkrehi 2587 35 competitive competitive JJ cord-335975-m6lkrehi 2587 36 mechanism mechanism NN cord-335975-m6lkrehi 2587 37 between between IN cord-335975-m6lkrehi 2587 38 tramadol tramadol NN cord-335975-m6lkrehi 2587 39 and and CC cord-335975-m6lkrehi 2587 40 flumazenil flumazenil VB cord-335975-m6lkrehi 2587 41 on on IN cord-335975-m6lkrehi 2587 42 the the DT cord-335975-m6lkrehi 2587 43 benzodiazepine benzodiazepine NN cord-335975-m6lkrehi 2587 44 binding binding NN cord-335975-m6lkrehi 2587 45 site site NN cord-335975-m6lkrehi 2587 46 . . . cord-335975-m6lkrehi 2588 1 Our -PRON- PRP$ cord-335975-m6lkrehi 2588 2 findings finding NNS cord-335975-m6lkrehi 2588 3 clearly clearly RB cord-335975-m6lkrehi 2588 4 ruled rule VBD cord-335975-m6lkrehi 2588 5 out out RP cord-335975-m6lkrehi 2588 6 the the DT cord-335975-m6lkrehi 2588 7 involvement involvement NN cord-335975-m6lkrehi 2588 8 of of IN cord-335975-m6lkrehi 2588 9 serotoninergic serotoninergic NNP cord-335975-m6lkrehi 2588 10 , , , cord-335975-m6lkrehi 2588 11 opioidergic opioidergic JJ cord-335975-m6lkrehi 2588 12 , , , cord-335975-m6lkrehi 2588 13 histaminergic histaminergic JJ cord-335975-m6lkrehi 2588 14 , , , cord-335975-m6lkrehi 2588 15 dopaminergic dopaminergic JJ cord-335975-m6lkrehi 2588 16 and and CC cord-335975-m6lkrehi 2588 17 norepinephrinergic norepinephrinergic JJ cord-335975-m6lkrehi 2588 18 pathways pathway NNS cord-335975-m6lkrehi 2588 19 in in IN cord-335975-m6lkrehi 2588 20 tramadol tramadol NN cord-335975-m6lkrehi 2588 21 - - HYPH cord-335975-m6lkrehi 2588 22 induced induce VBN cord-335975-m6lkrehi 2588 23 seizures seizure NNS cord-335975-m6lkrehi 2588 24 while while IN cord-335975-m6lkrehi 2588 25 strongly strongly RB cord-335975-m6lkrehi 2588 26 suggested suggest VBD cord-335975-m6lkrehi 2588 27 tramadolinduced tramadolinduce VBN cord-335975-m6lkrehi 2588 28 specific specific JJ cord-335975-m6lkrehi 2588 29 allosteric allosteric JJ cord-335975-m6lkrehi 2588 30 change change NN cord-335975-m6lkrehi 2588 31 in in IN cord-335975-m6lkrehi 2588 32 GABAA GABAA NNP cord-335975-m6lkrehi 2588 33 receptors receptor NNS cord-335975-m6lkrehi 2588 34 that that WDT cord-335975-m6lkrehi 2588 35 could could MD cord-335975-m6lkrehi 2588 36 contribute contribute VB cord-335975-m6lkrehi 2588 37 to to IN cord-335975-m6lkrehi 2588 38 seizures seizure NNS cord-335975-m6lkrehi 2588 39 onset onset VB cord-335975-m6lkrehi 2588 40 in in IN cord-335975-m6lkrehi 2588 41 overdose overdose NN cord-335975-m6lkrehi 2588 42 . . . cord-335975-m6lkrehi 2589 1 Conclusion conclusion NN cord-335975-m6lkrehi 2589 2 : : : cord-335975-m6lkrehi 2590 1 Tramadol tramadol NN cord-335975-m6lkrehi 2590 2 - - HYPH cord-335975-m6lkrehi 2590 3 induced induce VBN cord-335975-m6lkrehi 2590 4 seizures seizure NNS cord-335975-m6lkrehi 2590 5 in in IN cord-335975-m6lkrehi 2590 6 overdose overdose NN cord-335975-m6lkrehi 2590 7 are be VBP cord-335975-m6lkrehi 2590 8 mainly mainly RB cord-335975-m6lkrehi 2590 9 related relate VBN cord-335975-m6lkrehi 2590 10 to to IN cord-335975-m6lkrehi 2590 11 the the DT cord-335975-m6lkrehi 2590 12 GABAergic GABAergic NNP cord-335975-m6lkrehi 2590 13 pathway pathway NN cord-335975-m6lkrehi 2590 14 . . . cord-335975-m6lkrehi 2591 1 Introduction introduction NN cord-335975-m6lkrehi 2591 2 : : : cord-335975-m6lkrehi 2592 1 Heparin Heparin NNP cord-335975-m6lkrehi 2592 2 - - HYPH cord-335975-m6lkrehi 2592 3 Induced induce VBN cord-335975-m6lkrehi 2592 4 Thrombocytopenia Thrombocytopenia NNP cord-335975-m6lkrehi 2592 5 ( ( -LRB- cord-335975-m6lkrehi 2592 6 HIT hit NN cord-335975-m6lkrehi 2592 7 ) ) -RRB- cord-335975-m6lkrehi 2592 8 is be VBZ cord-335975-m6lkrehi 2592 9 a a DT cord-335975-m6lkrehi 2592 10 serious serious JJ cord-335975-m6lkrehi 2592 11 iatrogenic iatrogenic JJ cord-335975-m6lkrehi 2592 12 complication complication NN cord-335975-m6lkrehi 2592 13 of of IN cord-335975-m6lkrehi 2592 14 heparinic heparinic JJ cord-335975-m6lkrehi 2592 15 treatments treatment NNS cord-335975-m6lkrehi 2592 16 . . . cord-335975-m6lkrehi 2593 1 The the DT cord-335975-m6lkrehi 2593 2 diagnosis diagnosis NN cord-335975-m6lkrehi 2593 3 of of IN cord-335975-m6lkrehi 2593 4 HIT HIT NNP cord-335975-m6lkrehi 2593 5 is be VBZ cord-335975-m6lkrehi 2593 6 difficult difficult JJ cord-335975-m6lkrehi 2593 7 in in IN cord-335975-m6lkrehi 2593 8 the the DT cord-335975-m6lkrehi 2593 9 resuscitation resuscitation NN cord-335975-m6lkrehi 2593 10 environment environment NN cord-335975-m6lkrehi 2593 11 because because IN cord-335975-m6lkrehi 2593 12 thrombocytopenia thrombocytopenia NN cord-335975-m6lkrehi 2593 13 is be VBZ cord-335975-m6lkrehi 2593 14 a a DT cord-335975-m6lkrehi 2593 15 frequent frequent JJ cord-335975-m6lkrehi 2593 16 and and CC cord-335975-m6lkrehi 2593 17 multifactorial multifactorial JJ cord-335975-m6lkrehi 2593 18 phenomenon phenomenon NN cord-335975-m6lkrehi 2593 19 . . . cord-335975-m6lkrehi 2594 1 The the DT cord-335975-m6lkrehi 2594 2 aim aim NN cord-335975-m6lkrehi 2594 3 of of IN cord-335975-m6lkrehi 2594 4 this this DT cord-335975-m6lkrehi 2594 5 work work NN cord-335975-m6lkrehi 2594 6 was be VBD cord-335975-m6lkrehi 2594 7 to to TO cord-335975-m6lkrehi 2594 8 study study VB cord-335975-m6lkrehi 2594 9 the the DT cord-335975-m6lkrehi 2594 10 clinical clinical JJ cord-335975-m6lkrehi 2594 11 and and CC cord-335975-m6lkrehi 2594 12 biological biological JJ cord-335975-m6lkrehi 2594 13 presentation presentation NN cord-335975-m6lkrehi 2594 14 of of IN cord-335975-m6lkrehi 2594 15 patients patient NNS cord-335975-m6lkrehi 2594 16 with with IN cord-335975-m6lkrehi 2594 17 HIT hit NN cord-335975-m6lkrehi 2594 18 and and CC cord-335975-m6lkrehi 2594 19 the the DT cord-335975-m6lkrehi 2594 20 consequences consequence NNS cord-335975-m6lkrehi 2594 21 attributable attributable JJ cord-335975-m6lkrehi 2594 22 to to TO cord-335975-m6lkrehi 2594 23 HIT hit VB cord-335975-m6lkrehi 2594 24 on on IN cord-335975-m6lkrehi 2594 25 the the DT cord-335975-m6lkrehi 2594 26 evolution evolution NN cord-335975-m6lkrehi 2594 27 of of IN cord-335975-m6lkrehi 2594 28 patients patient NNS cord-335975-m6lkrehi 2594 29 in in IN cord-335975-m6lkrehi 2594 30 terms term NNS cord-335975-m6lkrehi 2594 31 of of IN cord-335975-m6lkrehi 2594 32 morbidity morbidity NN cord-335975-m6lkrehi 2594 33 and and CC cord-335975-m6lkrehi 2594 34 mortality mortality NN cord-335975-m6lkrehi 2594 35 and and CC cord-335975-m6lkrehi 2594 36 to to TO cord-335975-m6lkrehi 2594 37 develop develop VB cord-335975-m6lkrehi 2594 38 a a DT cord-335975-m6lkrehi 2594 39 diagnostic diagnostic JJ cord-335975-m6lkrehi 2594 40 strategy strategy NN cord-335975-m6lkrehi 2594 41 for for IN cord-335975-m6lkrehi 2594 42 HIT HIT VBN cord-335975-m6lkrehi 2594 43 for for IN cord-335975-m6lkrehi 2594 44 resuscitation resuscitation NN cord-335975-m6lkrehi 2594 45 patients patient NNS cord-335975-m6lkrehi 2594 46 . . . cord-335975-m6lkrehi 2595 1 This this DT cord-335975-m6lkrehi 2595 2 was be VBD cord-335975-m6lkrehi 2595 3 a a DT cord-335975-m6lkrehi 2595 4 retrospective retrospective JJ cord-335975-m6lkrehi 2595 5 , , , cord-335975-m6lkrehi 2595 6 monocentric monocentric JJ cord-335975-m6lkrehi 2595 7 , , , cord-335975-m6lkrehi 2595 8 descriptive descriptive JJ cord-335975-m6lkrehi 2595 9 and and CC cord-335975-m6lkrehi 2595 10 evaluative evaluative JJ cord-335975-m6lkrehi 2595 11 study study NN cord-335975-m6lkrehi 2595 12 conducted conduct VBN cord-335975-m6lkrehi 2595 13 in in IN cord-335975-m6lkrehi 2595 14 our -PRON- PRP$ cord-335975-m6lkrehi 2595 15 intensive intensive JJ cord-335975-m6lkrehi 2595 16 care care NN cord-335975-m6lkrehi 2595 17 unit unit NN cord-335975-m6lkrehi 2595 18 ( ( -LRB- cord-335975-m6lkrehi 2595 19 ICU ICU NNP cord-335975-m6lkrehi 2595 20 ) ) -RRB- cord-335975-m6lkrehi 2595 21 over over IN cord-335975-m6lkrehi 2595 22 a a DT cord-335975-m6lkrehi 2595 23 period period NN cord-335975-m6lkrehi 2595 24 of of IN cord-335975-m6lkrehi 2595 25 4 4 CD cord-335975-m6lkrehi 2595 26 years year NNS cord-335975-m6lkrehi 2595 27 6 6 CD cord-335975-m6lkrehi 2595 28 months month NNS cord-335975-m6lkrehi 2595 29 . . . cord-335975-m6lkrehi 2596 1 An an DT cord-335975-m6lkrehi 2596 2 anti anti JJ cord-335975-m6lkrehi 2596 3 - - JJ cord-335975-m6lkrehi 2596 4 PF4 pf4 JJ cord-335975-m6lkrehi 2596 5 antibody antibody NN cord-335975-m6lkrehi 2596 6 test test NN cord-335975-m6lkrehi 2596 7 was be VBD cord-335975-m6lkrehi 2596 8 performed perform VBN cord-335975-m6lkrehi 2596 9 in in IN cord-335975-m6lkrehi 2596 10 patients patient NNS cord-335975-m6lkrehi 2596 11 who who WP cord-335975-m6lkrehi 2596 12 developed develop VBD cord-335975-m6lkrehi 2596 13 thrombocytopenia thrombocytopenia NN cord-335975-m6lkrehi 2596 14 or or CC cord-335975-m6lkrehi 2596 15 a a DT cord-335975-m6lkrehi 2596 16 30 30 CD cord-335975-m6lkrehi 2596 17 % % NN cord-335975-m6lkrehi 2596 18 drop drop NN cord-335975-m6lkrehi 2596 19 in in IN cord-335975-m6lkrehi 2596 20 their -PRON- PRP$ cord-335975-m6lkrehi 2596 21 initial initial JJ cord-335975-m6lkrehi 2596 22 platelet platelet NN cord-335975-m6lkrehi 2596 23 kinetics kinetic NNS cord-335975-m6lkrehi 2596 24 and and CC cord-335975-m6lkrehi 2596 25 the the DT cord-335975-m6lkrehi 2596 26 clinical clinical JJ cord-335975-m6lkrehi 2596 27 picture picture NN cord-335975-m6lkrehi 2596 28 . . . cord-335975-m6lkrehi 2597 1 Results result NNS cord-335975-m6lkrehi 2597 2 : : : cord-335975-m6lkrehi 2598 1 The the DT cord-335975-m6lkrehi 2598 2 incidence incidence NN cord-335975-m6lkrehi 2598 3 of of IN cord-335975-m6lkrehi 2598 4 HIT HIT NNP cord-335975-m6lkrehi 2598 5 was be VBD cord-335975-m6lkrehi 2598 6 1.71 1.71 CD cord-335975-m6lkrehi 2598 7 % % NN cord-335975-m6lkrehi 2598 8 in in IN cord-335975-m6lkrehi 2598 9 patients patient NNS cord-335975-m6lkrehi 2598 10 hospitalized hospitalize VBN cord-335975-m6lkrehi 2598 11 in in IN cord-335975-m6lkrehi 2598 12 ICU ICU NNP cord-335975-m6lkrehi 2598 13 . . . cord-335975-m6lkrehi 2599 1 The the DT cord-335975-m6lkrehi 2599 2 clinicobiological clinicobiological JJ cord-335975-m6lkrehi 2599 3 severity severity NN cord-335975-m6lkrehi 2599 4 scores score NNS cord-335975-m6lkrehi 2599 5 , , , cord-335975-m6lkrehi 2599 6 the the DT cord-335975-m6lkrehi 2599 7 reasons reason NNS cord-335975-m6lkrehi 2599 8 for for IN cord-335975-m6lkrehi 2599 9 admission admission NN cord-335975-m6lkrehi 2599 10 to to IN cord-335975-m6lkrehi 2599 11 resuscitation resuscitation NN cord-335975-m6lkrehi 2599 12 were be VBD cord-335975-m6lkrehi 2599 13 similar similar JJ cord-335975-m6lkrehi 2599 14 in in IN cord-335975-m6lkrehi 2599 15 both both DT cord-335975-m6lkrehi 2599 16 groups group NNS cord-335975-m6lkrehi 2599 17 ( ( -LRB- cord-335975-m6lkrehi 2599 18 HIT+ HIT+ NNP cord-335975-m6lkrehi 2599 19 and and CC cord-335975-m6lkrehi 2599 20 HIT− HIT− NNP cord-335975-m6lkrehi 2599 21 ) ) -RRB- cord-335975-m6lkrehi 2599 22 as as RB cord-335975-m6lkrehi 2599 23 well well RB cord-335975-m6lkrehi 2599 24 as as IN cord-335975-m6lkrehi 2599 25 the the DT cord-335975-m6lkrehi 2599 26 characteristics characteristic NNS cord-335975-m6lkrehi 2599 27 of of IN cord-335975-m6lkrehi 2599 28 the the DT cord-335975-m6lkrehi 2599 29 heparins heparin NNS cord-335975-m6lkrehi 2599 30 used use VBD cord-335975-m6lkrehi 2599 31 . . . cord-335975-m6lkrehi 2600 1 The the DT cord-335975-m6lkrehi 2600 2 time time NN cord-335975-m6lkrehi 2600 3 of of IN cord-335975-m6lkrehi 2600 4 occurrence occurrence NN cord-335975-m6lkrehi 2600 5 of of IN cord-335975-m6lkrehi 2600 6 thrombocytopenia thrombocytopenia NN cord-335975-m6lkrehi 2600 7 was be VBD cord-335975-m6lkrehi 2600 8 similar similar JJ cord-335975-m6lkrehi 2600 9 in in IN cord-335975-m6lkrehi 2600 10 the the DT cord-335975-m6lkrehi 2600 11 two two CD cord-335975-m6lkrehi 2600 12 groups group NNS cord-335975-m6lkrehi 2600 13 . . . cord-335975-m6lkrehi 2601 1 The the DT cord-335975-m6lkrehi 2601 2 diagnosis diagnosis NN cord-335975-m6lkrehi 2601 3 of of IN cord-335975-m6lkrehi 2601 4 HIT HIT NNP cord-335975-m6lkrehi 2601 5 was be VBD cord-335975-m6lkrehi 2601 6 more more RBR cord-335975-m6lkrehi 2601 7 often often RB cord-335975-m6lkrehi 2601 8 the the DT cord-335975-m6lkrehi 2601 9 only only JJ cord-335975-m6lkrehi 2601 10 plausible plausible JJ cord-335975-m6lkrehi 2601 11 diagnosis diagnosis NN cord-335975-m6lkrehi 2601 12 in in IN cord-335975-m6lkrehi 2601 13 the the DT cord-335975-m6lkrehi 2601 14 HIT+ HIT+ NNP cord-335975-m6lkrehi 2601 15 group group NN cord-335975-m6lkrehi 2601 16 . . . cord-335975-m6lkrehi 2602 1 The the DT cord-335975-m6lkrehi 2602 2 4 4 CD cord-335975-m6lkrehi 2602 3 T t NN cord-335975-m6lkrehi 2602 4 's 's POS cord-335975-m6lkrehi 2602 5 score score NN cord-335975-m6lkrehi 2602 6 was be VBD cord-335975-m6lkrehi 2602 7 significantly significantly RB cord-335975-m6lkrehi 2602 8 higher high JJR cord-335975-m6lkrehi 2602 9 in in IN cord-335975-m6lkrehi 2602 10 the the DT cord-335975-m6lkrehi 2602 11 HIT+ HIT+ NNP cord-335975-m6lkrehi 2602 12 group group NN cord-335975-m6lkrehi 2602 13 . . . cord-335975-m6lkrehi 2603 1 The the DT cord-335975-m6lkrehi 2603 2 evolution evolution NN cord-335975-m6lkrehi 2603 3 of of IN cord-335975-m6lkrehi 2603 4 the the DT cord-335975-m6lkrehi 2603 5 platelet platelet NN cord-335975-m6lkrehi 2603 6 count count NN cord-335975-m6lkrehi 2603 7 was be VBD cord-335975-m6lkrehi 2603 8 similar similar JJ cord-335975-m6lkrehi 2603 9 in in IN cord-335975-m6lkrehi 2603 10 the the DT cord-335975-m6lkrehi 2603 11 two two CD cord-335975-m6lkrehi 2603 12 groups group NNS cord-335975-m6lkrehi 2603 13 , , , cord-335975-m6lkrehi 2603 14 in in IN cord-335975-m6lkrehi 2603 15 the the DT cord-335975-m6lkrehi 2603 16 decay decay NN cord-335975-m6lkrehi 2603 17 phases phase NNS cord-335975-m6lkrehi 2603 18 as as RB cord-335975-m6lkrehi 2603 19 well well RB cord-335975-m6lkrehi 2603 20 as as IN cord-335975-m6lkrehi 2603 21 in in IN cord-335975-m6lkrehi 2603 22 the the DT cord-335975-m6lkrehi 2603 23 recuperation recuperation NN cord-335975-m6lkrehi 2603 24 phase phase NN cord-335975-m6lkrehi 2603 25 . . . cord-335975-m6lkrehi 2604 1 HIT+ HIT+ NNP cord-335975-m6lkrehi 2604 2 patients patient NNS cord-335975-m6lkrehi 2604 3 showed show VBD cord-335975-m6lkrehi 2604 4 significantly significantly RB cord-335975-m6lkrehi 2604 5 more more JJR cord-335975-m6lkrehi 2604 6 thrombosis thrombosis NN cord-335975-m6lkrehi 2604 7 than than IN cord-335975-m6lkrehi 2604 8 HIT− hit− JJ cord-335975-m6lkrehi 2604 9 patients patient NNS cord-335975-m6lkrehi 2604 10 . . . cord-335975-m6lkrehi 2605 1 There there EX cord-335975-m6lkrehi 2605 2 was be VBD cord-335975-m6lkrehi 2605 3 no no DT cord-335975-m6lkrehi 2605 4 significant significant JJ cord-335975-m6lkrehi 2605 5 difference difference NN cord-335975-m6lkrehi 2605 6 between between IN cord-335975-m6lkrehi 2605 7 the the DT cord-335975-m6lkrehi 2605 8 transfusion transfusion NN cord-335975-m6lkrehi 2605 9 needs need NNS cord-335975-m6lkrehi 2605 10 of of IN cord-335975-m6lkrehi 2605 11 HIT+ HIT+ NNP cord-335975-m6lkrehi 2605 12 and and CC cord-335975-m6lkrehi 2605 13 HIT− HIT− NNP cord-335975-m6lkrehi 2605 14 patients patient NNS cord-335975-m6lkrehi 2605 15 . . . cord-335975-m6lkrehi 2606 1 Mortality mortality NN cord-335975-m6lkrehi 2606 2 was be VBD cord-335975-m6lkrehi 2606 3 identical identical JJ cord-335975-m6lkrehi 2606 4 in in IN cord-335975-m6lkrehi 2606 5 both both DT cord-335975-m6lkrehi 2606 6 groups group NNS cord-335975-m6lkrehi 2606 7 , , , cord-335975-m6lkrehi 2606 8 as as IN cord-335975-m6lkrehi 2606 9 was be VBD cord-335975-m6lkrehi 2606 10 the the DT cord-335975-m6lkrehi 2606 11 length length NN cord-335975-m6lkrehi 2606 12 of of IN cord-335975-m6lkrehi 2606 13 stay stay NN cord-335975-m6lkrehi 2606 14 in in IN cord-335975-m6lkrehi 2606 15 ICU ICU NNP cord-335975-m6lkrehi 2606 16 . . . cord-335975-m6lkrehi 2607 1 Conclusion conclusion NN cord-335975-m6lkrehi 2607 2 : : : cord-335975-m6lkrehi 2607 3 HIT hit VB cord-335975-m6lkrehi 2607 4 is be VBZ cord-335975-m6lkrehi 2607 5 a a DT cord-335975-m6lkrehi 2607 6 rare rare JJ cord-335975-m6lkrehi 2607 7 disease disease NN cord-335975-m6lkrehi 2607 8 . . . cord-335975-m6lkrehi 2608 1 There there EX cord-335975-m6lkrehi 2608 2 was be VBD cord-335975-m6lkrehi 2608 3 no no DT cord-335975-m6lkrehi 2608 4 evidence evidence NN cord-335975-m6lkrehi 2608 5 of of IN cord-335975-m6lkrehi 2608 6 a a DT cord-335975-m6lkrehi 2608 7 predisposing predisposing JJ cord-335975-m6lkrehi 2608 8 factor factor NN cord-335975-m6lkrehi 2608 9 for for IN cord-335975-m6lkrehi 2608 10 the the DT cord-335975-m6lkrehi 2608 11 occurrence occurrence NN cord-335975-m6lkrehi 2608 12 of of IN cord-335975-m6lkrehi 2608 13 the the DT cord-335975-m6lkrehi 2608 14 disease disease NN cord-335975-m6lkrehi 2608 15 in in IN cord-335975-m6lkrehi 2608 16 a a DT cord-335975-m6lkrehi 2608 17 uniform uniform JJ cord-335975-m6lkrehi 2608 18 resuscitation resuscitation NN cord-335975-m6lkrehi 2608 19 population population NN cord-335975-m6lkrehi 2608 20 . . . cord-335975-m6lkrehi 2609 1 The the DT cord-335975-m6lkrehi 2609 2 diagnosis diagnosis NN cord-335975-m6lkrehi 2609 3 of of IN cord-335975-m6lkrehi 2609 4 HIT HIT NNP cord-335975-m6lkrehi 2609 5 is be VBZ cord-335975-m6lkrehi 2609 6 based base VBN cord-335975-m6lkrehi 2609 7 on on IN cord-335975-m6lkrehi 2609 8 a a DT cord-335975-m6lkrehi 2609 9 cluster cluster NN cord-335975-m6lkrehi 2609 10 of of IN cord-335975-m6lkrehi 2609 11 arguments argument NNS cord-335975-m6lkrehi 2609 12 and and CC cord-335975-m6lkrehi 2609 13 not not RB cord-335975-m6lkrehi 2609 14 on on IN cord-335975-m6lkrehi 2609 15 an an DT cord-335975-m6lkrehi 2609 16 isolated isolated JJ cord-335975-m6lkrehi 2609 17 event event NN cord-335975-m6lkrehi 2609 18 . . . cord-335975-m6lkrehi 2610 1 Biological biological JJ cord-335975-m6lkrehi 2610 2 tools tool NNS cord-335975-m6lkrehi 2610 3 are be VBP cord-335975-m6lkrehi 2610 4 indispensable indispensable JJ cord-335975-m6lkrehi 2610 5 , , , cord-335975-m6lkrehi 2610 6 in in IN cord-335975-m6lkrehi 2610 7 a a DT cord-335975-m6lkrehi 2610 8 complementary complementary JJ cord-335975-m6lkrehi 2610 9 way way NN cord-335975-m6lkrehi 2610 10 to to IN cord-335975-m6lkrehi 2610 11 the the DT cord-335975-m6lkrehi 2610 12 clinical clinical JJ cord-335975-m6lkrehi 2610 13 picture picture NN cord-335975-m6lkrehi 2610 14 . . . cord-335975-m6lkrehi 2611 1 Pulmonary pulmonary JJ cord-335975-m6lkrehi 2611 2 embolism embolism NN cord-335975-m6lkrehi 2611 3 in in IN cord-335975-m6lkrehi 2611 4 patients patient NNS cord-335975-m6lkrehi 2611 5 with with IN cord-335975-m6lkrehi 2611 6 sickle sickle NN cord-335975-m6lkrehi 2611 7 cell cell NN cord-335975-m6lkrehi 2611 8 disease disease NN cord-335975-m6lkrehi 2611 9 in in IN cord-335975-m6lkrehi 2611 10 intensive intensive JJ cord-335975-m6lkrehi 2611 11 care care NN cord-335975-m6lkrehi 2611 12 unit unit NN cord-335975-m6lkrehi 2611 13 : : : cord-335975-m6lkrehi 2612 1 a a DT cord-335975-m6lkrehi 2612 2 challenging challenging JJ cord-335975-m6lkrehi 2612 3 diagnosis diagnosis NN cord-335975-m6lkrehi 2612 4 Jamoussi Jamoussi NNP cord-335975-m6lkrehi 2612 5 Amira Amira NNP cord-335975-m6lkrehi 2612 6 1 1 CD cord-335975-m6lkrehi 2612 7 , , , cord-335975-m6lkrehi 2612 8 Zayet Zayet NNP cord-335975-m6lkrehi 2612 9 Souheil Souheil NNP cord-335975-m6lkrehi 2612 10 1 1 CD cord-335975-m6lkrehi 2613 1 , , , cord-335975-m6lkrehi 2613 2 Merhebene Merhebene NNP cord-335975-m6lkrehi 2613 3 Takoua Takoua NNP cord-335975-m6lkrehi 2613 4 Results Results NNPS cord-335975-m6lkrehi 2613 5 : : : cord-335975-m6lkrehi 2613 6 During during IN cord-335975-m6lkrehi 2613 7 the the DT cord-335975-m6lkrehi 2613 8 study study NN cord-335975-m6lkrehi 2613 9 period period NN cord-335975-m6lkrehi 2613 10 , , , cord-335975-m6lkrehi 2613 11 a a DT cord-335975-m6lkrehi 2613 12 total total NN cord-335975-m6lkrehi 2613 13 of of IN cord-335975-m6lkrehi 2613 14 26 26 CD cord-335975-m6lkrehi 2613 15 patients patient NNS cord-335975-m6lkrehi 2613 16 with with IN cord-335975-m6lkrehi 2613 17 SCD SCD NNP cord-335975-m6lkrehi 2613 18 were be VBD cord-335975-m6lkrehi 2613 19 admitted admit VBN cord-335975-m6lkrehi 2613 20 . . . cord-335975-m6lkrehi 2614 1 Among among IN cord-335975-m6lkrehi 2614 2 them -PRON- PRP cord-335975-m6lkrehi 2614 3 , , , cord-335975-m6lkrehi 2614 4 20 20 CD cord-335975-m6lkrehi 2614 5 presented present VBN cord-335975-m6lkrehi 2614 6 with with IN cord-335975-m6lkrehi 2614 7 respiratory respiratory JJ cord-335975-m6lkrehi 2614 8 distress distress NN cord-335975-m6lkrehi 2614 9 and and CC cord-335975-m6lkrehi 2614 10 chest chest NN cord-335975-m6lkrehi 2614 11 pain pain NN cord-335975-m6lkrehi 2614 12 and and CC cord-335975-m6lkrehi 2614 13 then then RB cord-335975-m6lkrehi 2614 14 benefited benefit VBD cord-335975-m6lkrehi 2614 15 first first RB cord-335975-m6lkrehi 2614 16 of of IN cord-335975-m6lkrehi 2614 17 trans trans JJ cord-335975-m6lkrehi 2614 18 - - JJ cord-335975-m6lkrehi 2614 19 thoracic thoracic JJ cord-335975-m6lkrehi 2614 20 echocardiography echocardiography NN cord-335975-m6lkrehi 2614 21 that that WDT cord-335975-m6lkrehi 2614 22 often often RB cord-335975-m6lkrehi 2614 23 showed show VBD cord-335975-m6lkrehi 2614 24 right right JJ cord-335975-m6lkrehi 2614 25 ventricle ventricle NN cord-335975-m6lkrehi 2614 26 dilation dilation NN cord-335975-m6lkrehi 2614 27 and and CC cord-335975-m6lkrehi 2614 28 systolic systolic JJ cord-335975-m6lkrehi 2614 29 PAP pap NN cord-335975-m6lkrehi 2615 1 > > XX cord-335975-m6lkrehi 2615 2 30 30 CD cord-335975-m6lkrehi 2615 3 mmHg mmhg NN cord-335975-m6lkrehi 2615 4 ( ( -LRB- cord-335975-m6lkrehi 2615 5 n n NN cord-335975-m6lkrehi 2615 6 = = SYM cord-335975-m6lkrehi 2615 7 11 11 CD cord-335975-m6lkrehi 2615 8 ) ) -RRB- cord-335975-m6lkrehi 2615 9 . . . cord-335975-m6lkrehi 2616 1 All all PDT cord-335975-m6lkrehi 2616 2 the the DT cord-335975-m6lkrehi 2616 3 20 20 CD cord-335975-m6lkrehi 2616 4 patients patient NNS cord-335975-m6lkrehi 2616 5 underwent undergo VBD cord-335975-m6lkrehi 2616 6 enhanced enhance VBN cord-335975-m6lkrehi 2616 7 CT CT NNP cord-335975-m6lkrehi 2616 8 - - HYPH cord-335975-m6lkrehi 2616 9 scan scan NN cord-335975-m6lkrehi 2616 10 and and CC cord-335975-m6lkrehi 2616 11 the the DT cord-335975-m6lkrehi 2616 12 diagnosis diagnosis NN cord-335975-m6lkrehi 2616 13 of of IN cord-335975-m6lkrehi 2616 14 PE PE NNP cord-335975-m6lkrehi 2616 15 was be VBD cord-335975-m6lkrehi 2616 16 finally finally RB cord-335975-m6lkrehi 2616 17 retained retain VBN cord-335975-m6lkrehi 2616 18 in in IN cord-335975-m6lkrehi 2616 19 6 6 CD cord-335975-m6lkrehi 2616 20 cases case NNS cord-335975-m6lkrehi 2616 21 ( ( -LRB- cord-335975-m6lkrehi 2616 22 18.8 18.8 CD cord-335975-m6lkrehi 2616 23 % % NN cord-335975-m6lkrehi 2616 24 ) ) -RRB- cord-335975-m6lkrehi 2616 25 and and CC cord-335975-m6lkrehi 2616 26 hence hence RB cord-335975-m6lkrehi 2616 27 colliged colliged JJ cord-335975-m6lkrehi 2616 28 . . . cord-335975-m6lkrehi 2617 1 The the DT cord-335975-m6lkrehi 2617 2 average average JJ cord-335975-m6lkrehi 2617 3 age age NN cord-335975-m6lkrehi 2617 4 was be VBD cord-335975-m6lkrehi 2617 5 32.5 32.5 CD cord-335975-m6lkrehi 2617 6 years year NNS cord-335975-m6lkrehi 2617 7 ± ± CD cord-335975-m6lkrehi 2617 8 9.4 9.4 CD cord-335975-m6lkrehi 2617 9 [ [ -LRB- cord-335975-m6lkrehi 2617 10 20 20 CD cord-335975-m6lkrehi 2617 11 - - SYM cord-335975-m6lkrehi 2617 12 42 42 CD cord-335975-m6lkrehi 2617 13 years year NNS cord-335975-m6lkrehi 2617 14 ] ] -RRB- cord-335975-m6lkrehi 2617 15 with with IN cord-335975-m6lkrehi 2617 16 a a DT cord-335975-m6lkrehi 2617 17 sexratio sexratio NNP cord-335975-m6lkrehi 2617 18 = = SYM cord-335975-m6lkrehi 2617 19 1 1 CD cord-335975-m6lkrehi 2617 20 . . . cord-335975-m6lkrehi 2618 1 The the DT cord-335975-m6lkrehi 2618 2 mean mean NN cord-335975-m6lkrehi 2618 3 of of IN cord-335975-m6lkrehi 2618 4 APACH APACH NNP cord-335975-m6lkrehi 2618 5 II II NNP cord-335975-m6lkrehi 2618 6 score score NN cord-335975-m6lkrehi 2618 7 was be VBD cord-335975-m6lkrehi 2618 8 7 7 CD cord-335975-m6lkrehi 2618 9 . . . cord-335975-m6lkrehi 2619 1 SCD SCD NNP cord-335975-m6lkrehi 2619 2 were be VBD cord-335975-m6lkrehi 2619 3 diagnosed diagnose VBN cord-335975-m6lkrehi 2619 4 at at IN cord-335975-m6lkrehi 2619 5 the the DT cord-335975-m6lkrehi 2619 6 age age NN cord-335975-m6lkrehi 2619 7 of of IN cord-335975-m6lkrehi 2619 8 8.2 8.2 CD cord-335975-m6lkrehi 2619 9 years year NNS cord-335975-m6lkrehi 2619 10 ± ± CD cord-335975-m6lkrehi 2619 11 6.2 6.2 CD cord-335975-m6lkrehi 2619 12 [ [ -LRB- cord-335975-m6lkrehi 2619 13 3 3 CD cord-335975-m6lkrehi 2619 14 - - SYM cord-335975-m6lkrehi 2619 15 15 15 CD cord-335975-m6lkrehi 2619 16 years year NNS cord-335975-m6lkrehi 2619 17 ] ] -RRB- cord-335975-m6lkrehi 2619 18 with with IN cord-335975-m6lkrehi 2619 19 a a DT cord-335975-m6lkrehi 2619 20 regular regular JJ cord-335975-m6lkrehi 2619 21 follow follow NN cord-335975-m6lkrehi 2619 22 up up RB cord-335975-m6lkrehi 2619 23 in in IN cord-335975-m6lkrehi 2619 24 83 83 CD cord-335975-m6lkrehi 2619 25 % % NN cord-335975-m6lkrehi 2619 26 . . . cord-335975-m6lkrehi 2620 1 The the DT cord-335975-m6lkrehi 2620 2 reason reason NN cord-335975-m6lkrehi 2620 3 for for IN cord-335975-m6lkrehi 2620 4 admission admission NN cord-335975-m6lkrehi 2620 5 was be VBD cord-335975-m6lkrehi 2620 6 acute acute JJ cord-335975-m6lkrehi 2620 7 respiratory respiratory JJ cord-335975-m6lkrehi 2620 8 failure failure NN cord-335975-m6lkrehi 2620 9 in in IN cord-335975-m6lkrehi 2620 10 all all DT cord-335975-m6lkrehi 2620 11 cases case NNS cord-335975-m6lkrehi 2620 12 . . . cord-335975-m6lkrehi 2621 1 Patients patient NNS cord-335975-m6lkrehi 2621 2 had have VBD cord-335975-m6lkrehi 2621 3 clinical clinical JJ cord-335975-m6lkrehi 2621 4 symptoms symptom NNS cord-335975-m6lkrehi 2621 5 of of IN cord-335975-m6lkrehi 2621 6 pneumonia pneumonia NN cord-335975-m6lkrehi 2621 7 : : : cord-335975-m6lkrehi 2621 8 pleuritic pleuritic JJ cord-335975-m6lkrehi 2621 9 chest chest NN cord-335975-m6lkrehi 2621 10 pain pain NN cord-335975-m6lkrehi 2621 11 ( ( -LRB- cord-335975-m6lkrehi 2621 12 n n NN cord-335975-m6lkrehi 2621 13 = = SYM cord-335975-m6lkrehi 2621 14 6 6 CD cord-335975-m6lkrehi 2621 15 ) ) -RRB- cord-335975-m6lkrehi 2621 16 , , , cord-335975-m6lkrehi 2621 17 dyspnea dyspnea NN cord-335975-m6lkrehi 2621 18 ( ( -LRB- cord-335975-m6lkrehi 2621 19 n n NN cord-335975-m6lkrehi 2621 20 = = SYM cord-335975-m6lkrehi 2621 21 5 5 CD cord-335975-m6lkrehi 2621 22 ) ) -RRB- cord-335975-m6lkrehi 2621 23 and and CC cord-335975-m6lkrehi 2621 24 fever fever NN cord-335975-m6lkrehi 2621 25 ( ( -LRB- cord-335975-m6lkrehi 2621 26 n n NN cord-335975-m6lkrehi 2621 27 = = SYM cord-335975-m6lkrehi 2621 28 2 2 CD cord-335975-m6lkrehi 2621 29 ) ) -RRB- cord-335975-m6lkrehi 2621 30 . . . cord-335975-m6lkrehi 2622 1 All all DT cord-335975-m6lkrehi 2622 2 patients patient NNS cord-335975-m6lkrehi 2622 3 had have VBD cord-335975-m6lkrehi 2622 4 a a DT cord-335975-m6lkrehi 2622 5 chest chest NN cord-335975-m6lkrehi 2622 6 X x NN cord-335975-m6lkrehi 2622 7 - - NN cord-335975-m6lkrehi 2622 8 ray ray NN cord-335975-m6lkrehi 2622 9 showing show VBG cord-335975-m6lkrehi 2622 10 an an DT cord-335975-m6lkrehi 2622 11 alveolo alveolo NN cord-335975-m6lkrehi 2622 12 - - HYPH cord-335975-m6lkrehi 2622 13 interstitial interstitial JJ cord-335975-m6lkrehi 2622 14 syndrome syndrome NN cord-335975-m6lkrehi 2622 15 in in IN cord-335975-m6lkrehi 2622 16 4 4 CD cord-335975-m6lkrehi 2622 17 cases case NNS cord-335975-m6lkrehi 2622 18 ( ( -LRB- cord-335975-m6lkrehi 2622 19 66.6 66.6 CD cord-335975-m6lkrehi 2622 20 % % NN cord-335975-m6lkrehi 2622 21 ) ) -RRB- cord-335975-m6lkrehi 2622 22 and and CC cord-335975-m6lkrehi 2622 23 an an DT cord-335975-m6lkrehi 2622 24 associated associated JJ cord-335975-m6lkrehi 2622 25 pneumonia pneumonia NN cord-335975-m6lkrehi 2622 26 in in IN cord-335975-m6lkrehi 2622 27 2 2 CD cord-335975-m6lkrehi 2622 28 cases case NNS cord-335975-m6lkrehi 2622 29 ( ( -LRB- cord-335975-m6lkrehi 2622 30 Introduction introduction NN cord-335975-m6lkrehi 2622 31 : : : cord-335975-m6lkrehi 2622 32 Acute acute JJ cord-335975-m6lkrehi 2622 33 chest chest NN cord-335975-m6lkrehi 2622 34 syndrome syndrome NN cord-335975-m6lkrehi 2622 35 ( ( -LRB- cord-335975-m6lkrehi 2622 36 ACS ACS NNP cord-335975-m6lkrehi 2622 37 ) ) -RRB- cord-335975-m6lkrehi 2622 38 is be VBZ cord-335975-m6lkrehi 2622 39 the the DT cord-335975-m6lkrehi 2622 40 most most RBS cord-335975-m6lkrehi 2622 41 severe severe JJ cord-335975-m6lkrehi 2622 42 complication complication NN cord-335975-m6lkrehi 2622 43 of of IN cord-335975-m6lkrehi 2622 44 sickle sickle NN cord-335975-m6lkrehi 2622 45 cell cell NN cord-335975-m6lkrehi 2622 46 disease disease NN cord-335975-m6lkrehi 2622 47 and and CC cord-335975-m6lkrehi 2622 48 its -PRON- PRP$ cord-335975-m6lkrehi 2622 49 evolution evolution NN cord-335975-m6lkrehi 2622 50 is be VBZ cord-335975-m6lkrehi 2622 51 unpredictable unpredictable JJ cord-335975-m6lkrehi 2622 52 . . . cord-335975-m6lkrehi 2623 1 Acute acute JJ cord-335975-m6lkrehi 2623 2 pulmonary pulmonary JJ cord-335975-m6lkrehi 2623 3 hypertension hypertension NN cord-335975-m6lkrehi 2623 4 ( ( -LRB- cord-335975-m6lkrehi 2623 5 PH PH NNP cord-335975-m6lkrehi 2623 6 ) ) -RRB- cord-335975-m6lkrehi 2623 7 in in IN cord-335975-m6lkrehi 2623 8 ACS ACS NNP cord-335975-m6lkrehi 2623 9 is be VBZ cord-335975-m6lkrehi 2623 10 associated associate VBN cord-335975-m6lkrehi 2623 11 with with IN cord-335975-m6lkrehi 2623 12 an an DT cord-335975-m6lkrehi 2623 13 increased increase VBN cord-335975-m6lkrehi 2623 14 mortality mortality NN cord-335975-m6lkrehi 2623 15 , , , cord-335975-m6lkrehi 2623 16 but but CC cord-335975-m6lkrehi 2623 17 its -PRON- PRP$ cord-335975-m6lkrehi 2623 18 mechanism mechanism NN cord-335975-m6lkrehi 2623 19 remains remain VBZ cord-335975-m6lkrehi 2623 20 poorly poorly RB cord-335975-m6lkrehi 2623 21 known know VBN cord-335975-m6lkrehi 2623 22 . . . cord-335975-m6lkrehi 2624 1 Our -PRON- PRP$ cord-335975-m6lkrehi 2624 2 hypothesis hypothesis NN cord-335975-m6lkrehi 2624 3 is be VBZ cord-335975-m6lkrehi 2624 4 that that DT cord-335975-m6lkrehi 2624 5 acute acute JJ cord-335975-m6lkrehi 2624 6 PH ph NN cord-335975-m6lkrehi 2624 7 is be VBZ cord-335975-m6lkrehi 2624 8 associated associate VBN cord-335975-m6lkrehi 2624 9 with with IN cord-335975-m6lkrehi 2624 10 a a DT cord-335975-m6lkrehi 2624 11 biological biological JJ cord-335975-m6lkrehi 2624 12 state state NN cord-335975-m6lkrehi 2624 13 of of IN cord-335975-m6lkrehi 2624 14 hypercoagulability hypercoagulability NN cord-335975-m6lkrehi 2624 15 in in IN cord-335975-m6lkrehi 2624 16 ACS ACS NNP cord-335975-m6lkrehi 2624 17 . . . cord-335975-m6lkrehi 2625 1 In in IN cord-335975-m6lkrehi 2625 2 a a DT cord-335975-m6lkrehi 2625 3 prospective prospective JJ cord-335975-m6lkrehi 2625 4 single single JJ cord-335975-m6lkrehi 2625 5 center center NN cord-335975-m6lkrehi 2625 6 study study NN cord-335975-m6lkrehi 2625 7 , , , cord-335975-m6lkrehi 2625 8 all all DT cord-335975-m6lkrehi 2625 9 consecutive consecutive JJ cord-335975-m6lkrehi 2625 10 SCD SCD NNP cord-335975-m6lkrehi 2625 11 patients patient NNS cord-335975-m6lkrehi 2625 12 with with IN cord-335975-m6lkrehi 2625 13 ACS ACS NNP cord-335975-m6lkrehi 2625 14 admitted admit VBD cord-335975-m6lkrehi 2625 15 to to IN cord-335975-m6lkrehi 2625 16 the the DT cord-335975-m6lkrehi 2625 17 intensive intensive JJ cord-335975-m6lkrehi 2625 18 care care NN cord-335975-m6lkrehi 2625 19 unit unit NN cord-335975-m6lkrehi 2625 20 ( ( -LRB- cord-335975-m6lkrehi 2625 21 ICU ICU NNP cord-335975-m6lkrehi 2625 22 ) ) -RRB- cord-335975-m6lkrehi 2625 23 of of IN cord-335975-m6lkrehi 2625 24 Tenon Tenon NNP cord-335975-m6lkrehi 2625 25 hospital hospital NN cord-335975-m6lkrehi 2625 26 were be VBD cord-335975-m6lkrehi 2625 27 included include VBN cord-335975-m6lkrehi 2625 28 . . . cord-335975-m6lkrehi 2626 1 Specialized specialized JJ cord-335975-m6lkrehi 2626 2 haemostasis haemostasis NN cord-335975-m6lkrehi 2626 3 dosages dosage NNS cord-335975-m6lkrehi 2626 4 were be VBD cord-335975-m6lkrehi 2626 5 performed perform VBN cord-335975-m6lkrehi 2626 6 on on IN cord-335975-m6lkrehi 2626 7 ICU ICU NNP cord-335975-m6lkrehi 2626 8 admission admission NN cord-335975-m6lkrehi 2626 9 . . . cord-335975-m6lkrehi 2627 1 A a DT cord-335975-m6lkrehi 2627 2 trans trans JJ cord-335975-m6lkrehi 2627 3 - - JJ cord-335975-m6lkrehi 2627 4 thoracic thoracic JJ cord-335975-m6lkrehi 2627 5 echocardiogram echocardiogram NN cord-335975-m6lkrehi 2627 6 was be VBD cord-335975-m6lkrehi 2627 7 also also RB cord-335975-m6lkrehi 2627 8 performed perform VBN cord-335975-m6lkrehi 2627 9 on on IN cord-335975-m6lkrehi 2627 10 admission admission NN cord-335975-m6lkrehi 2627 11 , , , cord-335975-m6lkrehi 2627 12 and and CC cord-335975-m6lkrehi 2627 13 was be VBD cord-335975-m6lkrehi 2627 14 repeated repeat VBN cord-335975-m6lkrehi 2627 15 at at IN cord-335975-m6lkrehi 2627 16 steady steady JJ cord-335975-m6lkrehi 2627 17 state state NN cord-335975-m6lkrehi 2627 18 . . . cord-335975-m6lkrehi 2628 1 Results result NNS cord-335975-m6lkrehi 2628 2 : : : cord-335975-m6lkrehi 2629 1 Among among IN cord-335975-m6lkrehi 2629 2 29 29 CD cord-335975-m6lkrehi 2629 3 patients patient NNS cord-335975-m6lkrehi 2629 4 with with IN cord-335975-m6lkrehi 2629 5 ACS ACS NNP cord-335975-m6lkrehi 2629 6 , , , cord-335975-m6lkrehi 2629 7 22 22 CD cord-335975-m6lkrehi 2629 8 had have VBD cord-335975-m6lkrehi 2629 9 a a DT cord-335975-m6lkrehi 2629 10 trans trans JJ cord-335975-m6lkrehi 2629 11 - - JJ cord-335975-m6lkrehi 2629 12 thoracic thoracic JJ cord-335975-m6lkrehi 2629 13 echocardiogram echocardiogram NN cord-335975-m6lkrehi 2629 14 and and CC cord-335975-m6lkrehi 2629 15 6 6 CD cord-335975-m6lkrehi 2629 16 had have VBD cord-335975-m6lkrehi 2629 17 a a DT cord-335975-m6lkrehi 2629 18 high high JJ cord-335975-m6lkrehi 2629 19 echocardiographic echocardiographic JJ cord-335975-m6lkrehi 2629 20 probability probability NN cord-335975-m6lkrehi 2629 21 of of IN cord-335975-m6lkrehi 2629 22 acute acute JJ cord-335975-m6lkrehi 2629 23 PH PH NNP cord-335975-m6lkrehi 2629 24 , , , cord-335975-m6lkrehi 2629 25 including include VBG cord-335975-m6lkrehi 2629 26 1 1 CD cord-335975-m6lkrehi 2629 27 patient patient NN cord-335975-m6lkrehi 2629 28 with with IN cord-335975-m6lkrehi 2629 29 bilateral bilateral JJ cord-335975-m6lkrehi 2629 30 pulmonary pulmonary JJ cord-335975-m6lkrehi 2629 31 embolism embolism NN cord-335975-m6lkrehi 2629 32 and and CC cord-335975-m6lkrehi 2629 33 1 1 CD cord-335975-m6lkrehi 2629 34 patient patient NN cord-335975-m6lkrehi 2629 35 who who WP cord-335975-m6lkrehi 2629 36 developed develop VBD cord-335975-m6lkrehi 2629 37 multiple multiple JJ cord-335975-m6lkrehi 2629 38 organ organ NN cord-335975-m6lkrehi 2629 39 failure failure NN cord-335975-m6lkrehi 2629 40 and and CC cord-335975-m6lkrehi 2629 41 died die VBD cord-335975-m6lkrehi 2629 42 . . . cord-335975-m6lkrehi 2630 1 There there EX cord-335975-m6lkrehi 2630 2 were be VBD cord-335975-m6lkrehi 2630 3 no no DT cord-335975-m6lkrehi 2630 4 significant significant JJ cord-335975-m6lkrehi 2630 5 clinical clinical JJ cord-335975-m6lkrehi 2630 6 , , , cord-335975-m6lkrehi 2630 7 biological biological JJ cord-335975-m6lkrehi 2630 8 or or CC cord-335975-m6lkrehi 2630 9 radiological radiological JJ cord-335975-m6lkrehi 2630 10 differences difference NNS cord-335975-m6lkrehi 2630 11 between between IN cord-335975-m6lkrehi 2630 12 patients patient NNS cord-335975-m6lkrehi 2630 13 with with IN cord-335975-m6lkrehi 2630 14 a a DT cord-335975-m6lkrehi 2630 15 low low JJ cord-335975-m6lkrehi 2630 16 - - HYPH cord-335975-m6lkrehi 2630 17 intermediate intermediate JJ cord-335975-m6lkrehi 2630 18 probability probability NN cord-335975-m6lkrehi 2630 19 of of IN cord-335975-m6lkrehi 2630 20 acute acute JJ cord-335975-m6lkrehi 2630 21 PH PH NNP cord-335975-m6lkrehi 2630 22 and and CC cord-335975-m6lkrehi 2630 23 those those DT cord-335975-m6lkrehi 2630 24 with with IN cord-335975-m6lkrehi 2630 25 a a DT cord-335975-m6lkrehi 2630 26 high high JJ cord-335975-m6lkrehi 2630 27 probability probability NN cord-335975-m6lkrehi 2630 28 of of IN cord-335975-m6lkrehi 2630 29 acute acute JJ cord-335975-m6lkrehi 2630 30 PH+ PH+ NNS cord-335975-m6lkrehi 2631 1 their -PRON- PRP$ cord-335975-m6lkrehi 2631 2 evolution evolution NN cord-335975-m6lkrehi 2631 3 was be VBD cord-335975-m6lkrehi 2631 4 similar similar JJ cord-335975-m6lkrehi 2631 5 . . . cord-335975-m6lkrehi 2632 1 The the DT cord-335975-m6lkrehi 2632 2 exploration exploration NN cord-335975-m6lkrehi 2632 3 of of IN cord-335975-m6lkrehi 2632 4 haemostasis haemostasis NN cord-335975-m6lkrehi 2632 5 did do VBD cord-335975-m6lkrehi 2632 6 not not RB cord-335975-m6lkrehi 2632 7 show show VB cord-335975-m6lkrehi 2632 8 between between IN cord-335975-m6lkrehi 2632 9 - - HYPH cord-335975-m6lkrehi 2632 10 group group NN cord-335975-m6lkrehi 2632 11 differences difference NNS cord-335975-m6lkrehi 2632 12 , , , cord-335975-m6lkrehi 2632 13 regarding regard VBG cord-335975-m6lkrehi 2632 14 each each DT cord-335975-m6lkrehi 2632 15 parameter parameter NN cord-335975-m6lkrehi 2632 16 of of IN cord-335975-m6lkrehi 2632 17 haemostasis haemostasis NN cord-335975-m6lkrehi 2632 18 . . . cord-335975-m6lkrehi 2633 1 However however RB cord-335975-m6lkrehi 2633 2 , , , cord-335975-m6lkrehi 2633 3 when when WRB cord-335975-m6lkrehi 2633 4 using use VBG cord-335975-m6lkrehi 2633 5 a a DT cord-335975-m6lkrehi 2633 6 hierarchical hierarchical JJ cord-335975-m6lkrehi 2633 7 cluster cluster NN cord-335975-m6lkrehi 2633 8 analysis analysis NN cord-335975-m6lkrehi 2633 9 , , , cord-335975-m6lkrehi 2633 10 distinct distinct JJ cord-335975-m6lkrehi 2633 11 profiles profile NNS cord-335975-m6lkrehi 2633 12 of of IN cord-335975-m6lkrehi 2633 13 coagulation coagulation NN cord-335975-m6lkrehi 2633 14 were be VBD cord-335975-m6lkrehi 2633 15 evidenced evidence VBN cord-335975-m6lkrehi 2633 16 , , , cord-335975-m6lkrehi 2633 17 defining define VBG cord-335975-m6lkrehi 2633 18 3 3 CD cord-335975-m6lkrehi 2633 19 biological biological JJ cord-335975-m6lkrehi 2633 20 classes class NNS cord-335975-m6lkrehi 2633 21 . . . cord-335975-m6lkrehi 2634 1 The the DT cord-335975-m6lkrehi 2634 2 subset subset NN cord-335975-m6lkrehi 2634 3 of of IN cord-335975-m6lkrehi 2634 4 patients patient NNS cord-335975-m6lkrehi 2634 5 with with IN cord-335975-m6lkrehi 2634 6 a a DT cord-335975-m6lkrehi 2634 7 high high JJ cord-335975-m6lkrehi 2634 8 echocardiographic echocardiographic JJ cord-335975-m6lkrehi 2634 9 probability probability NN cord-335975-m6lkrehi 2634 10 of of IN cord-335975-m6lkrehi 2634 11 acute acute JJ cord-335975-m6lkrehi 2634 12 PH PH NNP cord-335975-m6lkrehi 2634 13 was be VBD cord-335975-m6lkrehi 2634 14 more more RBR cord-335975-m6lkrehi 2634 15 frequent frequent JJ cord-335975-m6lkrehi 2634 16 in in IN cord-335975-m6lkrehi 2634 17 biological biological JJ cord-335975-m6lkrehi 2634 18 classes class NNS cord-335975-m6lkrehi 2634 19 2 2 CD cord-335975-m6lkrehi 2634 20 and and CC cord-335975-m6lkrehi 2634 21 3 3 CD cord-335975-m6lkrehi 2634 22 which which WDT cord-335975-m6lkrehi 2634 23 corresponded correspond VBD cord-335975-m6lkrehi 2634 24 to to IN cord-335975-m6lkrehi 2634 25 hypercoagulability hypercoagulability NN cord-335975-m6lkrehi 2634 26 states state NNS cord-335975-m6lkrehi 2634 27 . . . cord-335975-m6lkrehi 2635 1 Acute acute JJ cord-335975-m6lkrehi 2635 2 PH PH NNP cord-335975-m6lkrehi 2635 3 was be VBD cord-335975-m6lkrehi 2635 4 transient transient JJ cord-335975-m6lkrehi 2635 5 in in IN cord-335975-m6lkrehi 2635 6 patients patient NNS cord-335975-m6lkrehi 2635 7 ( ( -LRB- cord-335975-m6lkrehi 2635 8 n n NN cord-335975-m6lkrehi 2635 9 = = SYM cord-335975-m6lkrehi 2635 10 17 17 CD cord-335975-m6lkrehi 2635 11 ) ) -RRB- cord-335975-m6lkrehi 2635 12 with with IN cord-335975-m6lkrehi 2635 13 a a DT cord-335975-m6lkrehi 2635 14 repeated repeat VBN cord-335975-m6lkrehi 2635 15 echocardiography echocardiography NN cord-335975-m6lkrehi 2635 16 at at IN cord-335975-m6lkrehi 2635 17 steady steady JJ cord-335975-m6lkrehi 2635 18 state state NN cord-335975-m6lkrehi 2635 19 . . . cord-335975-m6lkrehi 2636 1 Conclusion conclusion NN cord-335975-m6lkrehi 2636 2 : : : cord-335975-m6lkrehi 2637 1 Acute acute JJ cord-335975-m6lkrehi 2637 2 PH PH NNP cord-335975-m6lkrehi 2637 3 may may MD cord-335975-m6lkrehi 2637 4 likely likely RB cord-335975-m6lkrehi 2637 5 occur occur VB cord-335975-m6lkrehi 2637 6 in in IN cord-335975-m6lkrehi 2637 7 patients patient NNS cord-335975-m6lkrehi 2637 8 with with IN cord-335975-m6lkrehi 2637 9 ACS ACS NNP cord-335975-m6lkrehi 2637 10 and and CC cord-335975-m6lkrehi 2637 11 a a DT cord-335975-m6lkrehi 2637 12 biological biological JJ cord-335975-m6lkrehi 2637 13 condition condition NN cord-335975-m6lkrehi 2637 14 of of IN cord-335975-m6lkrehi 2637 15 hypercoagulability hypercoagulability NN cord-335975-m6lkrehi 2637 16 . . . cord-335975-m6lkrehi 2638 1 Further further JJ cord-335975-m6lkrehi 2638 2 studies study NNS cord-335975-m6lkrehi 2638 3 are be VBP cord-335975-m6lkrehi 2638 4 needed need VBN cord-335975-m6lkrehi 2638 5 to to TO cord-335975-m6lkrehi 2638 6 confirm confirm VB cord-335975-m6lkrehi 2638 7 these these DT cord-335975-m6lkrehi 2638 8 findings finding NNS cord-335975-m6lkrehi 2638 9 . . . cord-335975-m6lkrehi 2639 1 Gorham Gorham NNP cord-335975-m6lkrehi 2639 2 Julie Julie NNP cord-335975-m6lkrehi 2639 3 were be VBD cord-335975-m6lkrehi 2639 4 the the DT cord-335975-m6lkrehi 2639 5 two two CD cord-335975-m6lkrehi 2639 6 independent independent JJ cord-335975-m6lkrehi 2639 7 predictors predictor NNS cord-335975-m6lkrehi 2639 8 of of IN cord-335975-m6lkrehi 2639 9 survival survival NN cord-335975-m6lkrehi 2639 10 after after IN cord-335975-m6lkrehi 2639 11 hospital hospital NN cord-335975-m6lkrehi 2639 12 discharge discharge NN cord-335975-m6lkrehi 2639 13 . . . cord-335975-m6lkrehi 2640 1 In in IN cord-335975-m6lkrehi 2640 2 lung lung NN cord-335975-m6lkrehi 2640 3 cancer cancer NN cord-335975-m6lkrehi 2640 4 patients patient NNS cord-335975-m6lkrehi 2640 5 admitted admit VBD cord-335975-m6lkrehi 2640 6 into into IN cord-335975-m6lkrehi 2640 7 the the DT cord-335975-m6lkrehi 2640 8 ICU ICU NNP cord-335975-m6lkrehi 2640 9 , , , cord-335975-m6lkrehi 2640 10 the the DT cord-335975-m6lkrehi 2640 11 mGPS mgps NN cord-335975-m6lkrehi 2640 12 is be VBZ cord-335975-m6lkrehi 2640 13 an an DT cord-335975-m6lkrehi 2640 14 independent independent JJ cord-335975-m6lkrehi 2640 15 predictor predictor NN cord-335975-m6lkrehi 2640 16 of of IN cord-335975-m6lkrehi 2640 17 survival survival NN cord-335975-m6lkrehi 2640 18 after after IN cord-335975-m6lkrehi 2640 19 hospital hospital NN cord-335975-m6lkrehi 2640 20 discharge discharge NN cord-335975-m6lkrehi 2640 21 but but CC cord-335975-m6lkrehi 2640 22 not not RB cord-335975-m6lkrehi 2640 23 for for IN cord-335975-m6lkrehi 2640 24 mortality mortality NN cord-335975-m6lkrehi 2640 25 during during IN cord-335975-m6lkrehi 2640 26 ICU ICU NNP cord-335975-m6lkrehi 2640 27 stay stay NN cord-335975-m6lkrehi 2640 28 . . . cord-335975-m6lkrehi 2641 1 This this DT cord-335975-m6lkrehi 2641 2 inflammatory inflammatory JJ cord-335975-m6lkrehi 2641 3 score score NN cord-335975-m6lkrehi 2641 4 could could MD cord-335975-m6lkrehi 2641 5 therefore therefore RB cord-335975-m6lkrehi 2641 6 be be VB cord-335975-m6lkrehi 2641 7 used use VBN cord-335975-m6lkrehi 2641 8 as as IN cord-335975-m6lkrehi 2641 9 a a DT cord-335975-m6lkrehi 2641 10 long long JJ cord-335975-m6lkrehi 2641 11 - - HYPH cord-335975-m6lkrehi 2641 12 term term NN cord-335975-m6lkrehi 2641 13 prognostic prognostic JJ cord-335975-m6lkrehi 2641 14 marker marker NN cord-335975-m6lkrehi 2641 15 in in IN cord-335975-m6lkrehi 2641 16 this this DT cord-335975-m6lkrehi 2641 17 population population NN cord-335975-m6lkrehi 2641 18 of of IN cord-335975-m6lkrehi 2641 19 patients patient NNS cord-335975-m6lkrehi 2641 20 and and CC cord-335975-m6lkrehi 2641 21 would would MD cord-335975-m6lkrehi 2641 22 be be VB cord-335975-m6lkrehi 2641 23 more more RBR cord-335975-m6lkrehi 2641 24 reflective reflective JJ cord-335975-m6lkrehi 2641 25 of of IN cord-335975-m6lkrehi 2641 26 cancer cancer NN cord-335975-m6lkrehi 2641 27 , , , cord-335975-m6lkrehi 2641 28 than than IN cord-335975-m6lkrehi 2641 29 reflecting reflect VBG cord-335975-m6lkrehi 2641 30 the the DT cord-335975-m6lkrehi 2641 31 acute acute JJ cord-335975-m6lkrehi 2641 32 complication complication NN cord-335975-m6lkrehi 2641 33 leading lead VBG cord-335975-m6lkrehi 2641 34 to to IN cord-335975-m6lkrehi 2641 35 ICU ICU NNP cord-335975-m6lkrehi 2641 36 admission admission NN cord-335975-m6lkrehi 2641 37 . . . cord-335975-m6lkrehi 2642 1 Prospective prospective JJ cord-335975-m6lkrehi 2642 2 and and CC cord-335975-m6lkrehi 2642 3 multicentric multicentric JJ cord-335975-m6lkrehi 2642 4 studies study NNS cord-335975-m6lkrehi 2642 5 must must MD cord-335975-m6lkrehi 2642 6 be be VB cord-335975-m6lkrehi 2642 7 carried carry VBN cord-335975-m6lkrehi 2642 8 out out RP cord-335975-m6lkrehi 2642 9 to to TO cord-335975-m6lkrehi 2642 10 validate validate VB cord-335975-m6lkrehi 2642 11 these these DT cord-335975-m6lkrehi 2642 12 results result NNS cord-335975-m6lkrehi 2642 13 . . . cord-335975-m6lkrehi 2643 1 Introduction introduction NN cord-335975-m6lkrehi 2643 2 : : : cord-335975-m6lkrehi 2643 3 Recombinant recombinant JJ cord-335975-m6lkrehi 2643 4 active active JJ cord-335975-m6lkrehi 2643 5 factor factor NN cord-335975-m6lkrehi 2644 1 VII VII NNP cord-335975-m6lkrehi 2644 2 is be VBZ cord-335975-m6lkrehi 2644 3 a a DT cord-335975-m6lkrehi 2644 4 pro pro JJ cord-335975-m6lkrehi 2644 5 - - JJ cord-335975-m6lkrehi 2644 6 hemostatic hemostatic JJ cord-335975-m6lkrehi 2644 7 treatment treatment NN cord-335975-m6lkrehi 2644 8 used use VBN cord-335975-m6lkrehi 2644 9 in in IN cord-335975-m6lkrehi 2644 10 obstetric obstetric JJ cord-335975-m6lkrehi 2644 11 haemorrhage haemorrhage NN cord-335975-m6lkrehi 2644 12 , , , cord-335975-m6lkrehi 2644 13 but but CC cord-335975-m6lkrehi 2644 14 no no DT cord-335975-m6lkrehi 2644 15 study study NN cord-335975-m6lkrehi 2644 16 has have VBZ cord-335975-m6lkrehi 2644 17 made make VBN cord-335975-m6lkrehi 2644 18 it -PRON- PRP cord-335975-m6lkrehi 2644 19 possible possible JJ cord-335975-m6lkrehi 2644 20 to to TO cord-335975-m6lkrehi 2644 21 specify specify VB cord-335975-m6lkrehi 2644 22 its -PRON- PRP$ cord-335975-m6lkrehi 2644 23 exact exact JJ cord-335975-m6lkrehi 2644 24 place place NN cord-335975-m6lkrehi 2644 25 in in IN cord-335975-m6lkrehi 2644 26 the the DT cord-335975-m6lkrehi 2644 27 decision decision NN cord-335975-m6lkrehi 2644 28 algorithm algorithm NN cord-335975-m6lkrehi 2644 29 . . . cord-335975-m6lkrehi 2645 1 The the DT cord-335975-m6lkrehi 2645 2 objective objective NN cord-335975-m6lkrehi 2645 3 of of IN cord-335975-m6lkrehi 2645 4 our -PRON- PRP$ cord-335975-m6lkrehi 2645 5 work work NN cord-335975-m6lkrehi 2645 6 is be VBZ cord-335975-m6lkrehi 2645 7 to to TO cord-335975-m6lkrehi 2645 8 evaluate evaluate VB cord-335975-m6lkrehi 2645 9 the the DT cord-335975-m6lkrehi 2645 10 efficacy efficacy NN cord-335975-m6lkrehi 2645 11 and and CC cord-335975-m6lkrehi 2645 12 the the DT cord-335975-m6lkrehi 2645 13 benefit benefit NN cord-335975-m6lkrehi 2645 14 risk risk NN cord-335975-m6lkrehi 2645 15 ratio ratio NN cord-335975-m6lkrehi 2645 16 of of IN cord-335975-m6lkrehi 2645 17 recombinant recombinant JJ cord-335975-m6lkrehi 2645 18 factor factor NN cord-335975-m6lkrehi 2645 19 VIIa VIIa NNS cord-335975-m6lkrehi 2645 20 in in IN cord-335975-m6lkrehi 2645 21 the the DT cord-335975-m6lkrehi 2645 22 treatment treatment NN cord-335975-m6lkrehi 2645 23 of of IN cord-335975-m6lkrehi 2645 24 severe severe JJ cord-335975-m6lkrehi 2645 25 postpartum postpartum NN cord-335975-m6lkrehi 2645 26 hemorrhage hemorrhage NN cord-335975-m6lkrehi 2645 27 . . . cord-335975-m6lkrehi 2646 1 We -PRON- PRP cord-335975-m6lkrehi 2646 2 conducted conduct VBD cord-335975-m6lkrehi 2646 3 a a DT cord-335975-m6lkrehi 2646 4 prospective prospective JJ cord-335975-m6lkrehi 2646 5 study study NN cord-335975-m6lkrehi 2646 6 at at IN cord-335975-m6lkrehi 2646 7 the the DT cord-335975-m6lkrehi 2646 8 IBN IBN NNP cord-335975-m6lkrehi 2646 9 JAZZAR JAZZAR NNP cord-335975-m6lkrehi 2646 10 University University NNP cord-335975-m6lkrehi 2646 11 Hospital Hospital NNP cord-335975-m6lkrehi 2646 12 in in IN cord-335975-m6lkrehi 2646 13 Kairouan Kairouan NNP cord-335975-m6lkrehi 2646 14 during during IN cord-335975-m6lkrehi 2646 15 the the DT cord-335975-m6lkrehi 2646 16 period period NN cord-335975-m6lkrehi 2646 17 from from IN cord-335975-m6lkrehi 2646 18 January January NNP cord-335975-m6lkrehi 2646 19 1 1 CD cord-335975-m6lkrehi 2646 20 , , , cord-335975-m6lkrehi 2646 21 2015to 2015to JJ cord-335975-m6lkrehi 2646 22 December December NNP cord-335975-m6lkrehi 2646 23 31 31 CD cord-335975-m6lkrehi 2646 24 , , , cord-335975-m6lkrehi 2646 25 2016 2016 CD cord-335975-m6lkrehi 2646 26 . . . cord-335975-m6lkrehi 2647 1 In in IN cord-335975-m6lkrehi 2647 2 total total NN cord-335975-m6lkrehi 2647 3 , , , cord-335975-m6lkrehi 2647 4 we -PRON- PRP cord-335975-m6lkrehi 2647 5 collected collect VBD cord-335975-m6lkrehi 2647 6 15 15 CD cord-335975-m6lkrehi 2647 7 cases case NNS cord-335975-m6lkrehi 2647 8 of of IN cord-335975-m6lkrehi 2647 9 recombinant recombinant JJ cord-335975-m6lkrehi 2647 10 factor factor NN cord-335975-m6lkrehi 2647 11 VIIa VIIa NNS cord-335975-m6lkrehi 2647 12 in in IN cord-335975-m6lkrehi 2647 13 one one CD cord-335975-m6lkrehi 2647 14 postpartum postpartum NN cord-335975-m6lkrehi 2647 15 haemorrhage haemorrhage NN cord-335975-m6lkrehi 2647 16 . . . cord-335975-m6lkrehi 2648 1 Results result NNS cord-335975-m6lkrehi 2648 2 : : : cord-335975-m6lkrehi 2649 1 The the DT cord-335975-m6lkrehi 2649 2 mean mean JJ cord-335975-m6lkrehi 2649 3 age age NN cord-335975-m6lkrehi 2649 4 of of IN cord-335975-m6lkrehi 2649 5 our -PRON- PRP$ cord-335975-m6lkrehi 2649 6 patients patient NNS cord-335975-m6lkrehi 2649 7 was be VBD cord-335975-m6lkrehi 2649 8 31 31 CD cord-335975-m6lkrehi 2649 9 + + CD cord-335975-m6lkrehi 2649 10 5.96 5.96 CD cord-335975-m6lkrehi 2649 11 years year NNS cord-335975-m6lkrehi 2649 12 . . . cord-335975-m6lkrehi 2650 1 The the DT cord-335975-m6lkrehi 2650 2 rate rate NN cord-335975-m6lkrehi 2650 3 of of IN cord-335975-m6lkrehi 2650 4 childbirth childbirth NN cord-335975-m6lkrehi 2650 5 was be VBD cord-335975-m6lkrehi 2650 6 33.33 33.33 CD cord-335975-m6lkrehi 2650 7 % % NN cord-335975-m6lkrehi 2650 8 . . . cord-335975-m6lkrehi 2651 1 The the DT cord-335975-m6lkrehi 2651 2 caesarean caesarean NN cord-335975-m6lkrehi 2651 3 was be VBD cord-335975-m6lkrehi 2651 4 the the DT cord-335975-m6lkrehi 2651 5 mode mode NN cord-335975-m6lkrehi 2651 6 of of IN cord-335975-m6lkrehi 2651 7 delivery delivery NN cord-335975-m6lkrehi 2651 8 chosen choose VBN cord-335975-m6lkrehi 2651 9 for for IN cord-335975-m6lkrehi 2651 10 10 10 CD cord-335975-m6lkrehi 2651 11 patients patient NNS cord-335975-m6lkrehi 2651 12 . . . cord-335975-m6lkrehi 2652 1 The the DT cord-335975-m6lkrehi 2652 2 causes cause NNS cord-335975-m6lkrehi 2652 3 of of IN cord-335975-m6lkrehi 2652 4 postpartum postpartum NN cord-335975-m6lkrehi 2652 5 haemorrhage haemorrhage NN cord-335975-m6lkrehi 2652 6 in in IN cord-335975-m6lkrehi 2652 7 our -PRON- PRP$ cord-335975-m6lkrehi 2652 8 series series NN cord-335975-m6lkrehi 2652 9 were be VBD cord-335975-m6lkrehi 2652 10 - - HYPH cord-335975-m6lkrehi 2652 11 uterine uterine JJ cord-335975-m6lkrehi 2652 12 atony atony NN cord-335975-m6lkrehi 2652 13 in in IN cord-335975-m6lkrehi 2652 14 5 5 CD cord-335975-m6lkrehi 2652 15 cases case NNS cord-335975-m6lkrehi 2652 16 , , , cord-335975-m6lkrehi 2652 17 uterine uterine JJ cord-335975-m6lkrehi 2652 18 rupture rupture NN cord-335975-m6lkrehi 2652 19 and and CC cord-335975-m6lkrehi 2652 20 cervicouterine cervicouterine NN cord-335975-m6lkrehi 2652 21 tear tear NN cord-335975-m6lkrehi 2652 22 3 3 CD cord-335975-m6lkrehi 2652 23 cases case NNS cord-335975-m6lkrehi 2652 24 each each DT cord-335975-m6lkrehi 2652 25 , , , cord-335975-m6lkrehi 2652 26 retroplacental retroplacental JJ cord-335975-m6lkrehi 2652 27 hematoma hematoma NN cord-335975-m6lkrehi 2652 28 and and CC cord-335975-m6lkrehi 2652 29 placenta placenta NN cord-335975-m6lkrehi 2652 30 accreta accreta NN cord-335975-m6lkrehi 2652 31 1 1 CD cord-335975-m6lkrehi 2652 32 cases case NNS cord-335975-m6lkrehi 2652 33 for for IN cord-335975-m6lkrehi 2652 34 each each DT cord-335975-m6lkrehi 2652 35 two two CD cord-335975-m6lkrehi 2652 36 and and CC cord-335975-m6lkrehi 2652 37 placenta placenta NN cord-335975-m6lkrehi 2652 38 praevia praevia NNS cord-335975-m6lkrehi 2652 39 in in IN cord-335975-m6lkrehi 2652 40 2 2 CD cord-335975-m6lkrehi 2652 41 cases case NNS cord-335975-m6lkrehi 2652 42 . . . cord-335975-m6lkrehi 2653 1 Our -PRON- PRP$ cord-335975-m6lkrehi 2653 2 patients patient NNS cord-335975-m6lkrehi 2653 3 were be VBD cord-335975-m6lkrehi 2653 4 treated treat VBN cord-335975-m6lkrehi 2653 5 in in IN cord-335975-m6lkrehi 2653 6 an an DT cord-335975-m6lkrehi 2653 7 intensive intensive JJ cord-335975-m6lkrehi 2653 8 care care NN cord-335975-m6lkrehi 2653 9 unit unit NN cord-335975-m6lkrehi 2653 10 and and CC cord-335975-m6lkrehi 2653 11 the the DT cord-335975-m6lkrehi 2653 12 average average JJ cord-335975-m6lkrehi 2653 13 hospital hospital NN cord-335975-m6lkrehi 2653 14 stay stay NN cord-335975-m6lkrehi 2653 15 was be VBD cord-335975-m6lkrehi 2653 16 4.1 4.1 CD cord-335975-m6lkrehi 2653 17 days day NNS cord-335975-m6lkrehi 2653 18 . . . cord-335975-m6lkrehi 2654 1 Sulprostone Sulprostone NNP cord-335975-m6lkrehi 2654 2 was be VBD cord-335975-m6lkrehi 2654 3 reported report VBN cord-335975-m6lkrehi 2654 4 in in IN cord-335975-m6lkrehi 2654 5 7 7 CD cord-335975-m6lkrehi 2654 6 cases case NNS cord-335975-m6lkrehi 2654 7 ( ( -LRB- cord-335975-m6lkrehi 2654 8 46.6 46.6 CD cord-335975-m6lkrehi 2654 9 % % NN cord-335975-m6lkrehi 2654 10 ) ) -RRB- cord-335975-m6lkrehi 2654 11 , , , cord-335975-m6lkrehi 2654 12 and and CC cord-335975-m6lkrehi 2654 13 all all DT cord-335975-m6lkrehi 2654 14 patients patient NNS cord-335975-m6lkrehi 2654 15 received receive VBD cord-335975-m6lkrehi 2654 16 a a DT cord-335975-m6lkrehi 2654 17 massive massive JJ cord-335975-m6lkrehi 2654 18 transfusion transfusion NN cord-335975-m6lkrehi 2654 19 . . . cord-335975-m6lkrehi 2655 1 The the DT cord-335975-m6lkrehi 2655 2 average average JJ cord-335975-m6lkrehi 2655 3 time time NN cord-335975-m6lkrehi 2655 4 to to TO cord-335975-m6lkrehi 2655 5 administer administer VB cord-335975-m6lkrehi 2655 6 rFVIIa rfviia NN cord-335975-m6lkrehi 2655 7 was be VBD cord-335975-m6lkrehi 2655 8 6 6 CD cord-335975-m6lkrehi 2655 9 h h NN cord-335975-m6lkrehi 2655 10 40 40 CD cord-335975-m6lkrehi 2655 11 min min NN cord-335975-m6lkrehi 2655 12 . . . cord-335975-m6lkrehi 2656 1 The the DT cord-335975-m6lkrehi 2656 2 mean mean JJ cord-335975-m6lkrehi 2656 3 dose dose NN cord-335975-m6lkrehi 2656 4 of of IN cord-335975-m6lkrehi 2656 5 factor factor NN cord-335975-m6lkrehi 2656 6 VIla vila NN cord-335975-m6lkrehi 2656 7 recombinant recombinant NN cord-335975-m6lkrehi 2656 8 was be VBD cord-335975-m6lkrehi 2656 9 78.8 78.8 CD cord-335975-m6lkrehi 2656 10 ± ± CD cord-335975-m6lkrehi 2656 11 9.24 9.24 CD cord-335975-m6lkrehi 2656 12 μg μg NNP cord-335975-m6lkrehi 2656 13 kg kg NNS cord-335975-m6lkrehi 2656 14 . . . cord-335975-m6lkrehi 2657 1 Five five CD cord-335975-m6lkrehi 2657 2 patients patient NNS cord-335975-m6lkrehi 2657 3 received receive VBD cord-335975-m6lkrehi 2657 4 a a DT cord-335975-m6lkrehi 2657 5 single single JJ cord-335975-m6lkrehi 2657 6 dose dose NN cord-335975-m6lkrehi 2657 7 , , , cord-335975-m6lkrehi 2657 8 8 8 CD cord-335975-m6lkrehi 2657 9 patients patient NNS cord-335975-m6lkrehi 2657 10 received receive VBD cord-335975-m6lkrehi 2657 11 a a DT cord-335975-m6lkrehi 2657 12 second second JJ cord-335975-m6lkrehi 2657 13 injection injection NN cord-335975-m6lkrehi 2657 14 and and CC cord-335975-m6lkrehi 2657 15 2 2 CD cord-335975-m6lkrehi 2657 16 patients patient NNS cord-335975-m6lkrehi 2657 17 received receive VBD cord-335975-m6lkrehi 2657 18 3 3 CD cord-335975-m6lkrehi 2657 19 doses dose NNS cord-335975-m6lkrehi 2657 20 . . . cord-335975-m6lkrehi 2658 1 Clinical clinical JJ cord-335975-m6lkrehi 2658 2 efficacy- efficacy- NN cord-335975-m6lkrehi 2659 1 After after IN cord-335975-m6lkrehi 2659 2 a a DT cord-335975-m6lkrehi 2659 3 single single JJ cord-335975-m6lkrehi 2659 4 injection injection NN cord-335975-m6lkrehi 2659 5 , , , cord-335975-m6lkrehi 2659 6 clinical clinical JJ cord-335975-m6lkrehi 2659 7 efficacy efficacy NN cord-335975-m6lkrehi 2659 8 with with IN cord-335975-m6lkrehi 2659 9 reduction reduction NN cord-335975-m6lkrehi 2659 10 in in IN cord-335975-m6lkrehi 2659 11 bleeding bleeding NN cord-335975-m6lkrehi 2659 12 was be VBD cord-335975-m6lkrehi 2659 13 observed observe VBN cord-335975-m6lkrehi 2659 14 in in IN cord-335975-m6lkrehi 2659 15 8 8 CD cord-335975-m6lkrehi 2659 16 patients patient NNS cord-335975-m6lkrehi 2659 17 , , , cord-335975-m6lkrehi 2659 18 i.e. i.e. FW cord-335975-m6lkrehi 2659 19 60 60 CD cord-335975-m6lkrehi 2659 20 % % NN cord-335975-m6lkrehi 2659 21 . . . cord-335975-m6lkrehi 2660 1 The the DT cord-335975-m6lkrehi 2660 2 most most RBS cord-335975-m6lkrehi 2660 3 frequent frequent JJ cord-335975-m6lkrehi 2660 4 complication complication NN cord-335975-m6lkrehi 2660 5 was be VBD cord-335975-m6lkrehi 2660 6 insufficiencyrenal insufficiencyrenal JJ cord-335975-m6lkrehi 2660 7 in in IN cord-335975-m6lkrehi 2660 8 7 7 CD cord-335975-m6lkrehi 2660 9 cases case NNS cord-335975-m6lkrehi 2660 10 including include VBG cord-335975-m6lkrehi 2660 11 2 2 CD cord-335975-m6lkrehi 2660 12 requiring require VBG cord-335975-m6lkrehi 2660 13 hemodialysis hemodialysis NN cord-335975-m6lkrehi 2660 14 , , , cord-335975-m6lkrehi 2660 15 CIVD CIVD NNP cord-335975-m6lkrehi 2660 16 in in IN cord-335975-m6lkrehi 2660 17 4 4 CD cord-335975-m6lkrehi 2660 18 cases case NNS cord-335975-m6lkrehi 2660 19 , , , cord-335975-m6lkrehi 2660 20 OAP OAP NNP cord-335975-m6lkrehi 2660 21 in in IN cord-335975-m6lkrehi 2660 22 2 2 CD cord-335975-m6lkrehi 2660 23 cases case NNS cord-335975-m6lkrehi 2660 24 , , , cord-335975-m6lkrehi 2660 25 a a DT cord-335975-m6lkrehi 2660 26 multivisceral multivisceral JJ cord-335975-m6lkrehi 2660 27 failure failure NN cord-335975-m6lkrehi 2660 28 in in IN cord-335975-m6lkrehi 2660 29 2 2 CD cord-335975-m6lkrehi 2660 30 cases case NNS cord-335975-m6lkrehi 2660 31 , , , cord-335975-m6lkrehi 2660 32 a a DT cord-335975-m6lkrehi 2660 33 septic septic JJ cord-335975-m6lkrehi 2660 34 shock shock NN cord-335975-m6lkrehi 2660 35 in in IN cord-335975-m6lkrehi 2660 36 1 1 CD cord-335975-m6lkrehi 2660 37 case case NN cord-335975-m6lkrehi 2660 38 and and CC cord-335975-m6lkrehi 2660 39 a a DT cord-335975-m6lkrehi 2660 40 mesenteric mesenteric JJ cord-335975-m6lkrehi 2660 41 infarction infarction NN cord-335975-m6lkrehi 2660 42 in in IN cord-335975-m6lkrehi 2660 43 1 1 CD cord-335975-m6lkrehi 2660 44 case case NN cord-335975-m6lkrehi 2660 45 . . . cord-335975-m6lkrehi 2661 1 The the DT cord-335975-m6lkrehi 2661 2 progression progression NN cord-335975-m6lkrehi 2661 3 was be VBD cord-335975-m6lkrehi 2661 4 favorable favorable JJ cord-335975-m6lkrehi 2661 5 in in IN cord-335975-m6lkrehi 2661 6 12 12 CD cord-335975-m6lkrehi 2661 7 patients patient NNS cord-335975-m6lkrehi 2661 8 , , , cord-335975-m6lkrehi 2661 9 while while IN cord-335975-m6lkrehi 2661 10 3 3 CD cord-335975-m6lkrehi 2661 11 patients patient NNS cord-335975-m6lkrehi 2661 12 died die VBD cord-335975-m6lkrehi 2661 13 ( ( -LRB- cord-335975-m6lkrehi 2661 14 21.9 21.9 CD cord-335975-m6lkrehi 2661 15 % % NN cord-335975-m6lkrehi 2661 16 ) ) -RRB- cord-335975-m6lkrehi 2661 17 . . . cord-335975-m6lkrehi 2662 1 Conclusion conclusion NN cord-335975-m6lkrehi 2662 2 : : : cord-335975-m6lkrehi 2662 3 It -PRON- PRP cord-335975-m6lkrehi 2662 4 is be VBZ cord-335975-m6lkrehi 2662 5 important important JJ cord-335975-m6lkrehi 2662 6 that that IN cord-335975-m6lkrehi 2662 7 new new JJ cord-335975-m6lkrehi 2662 8 studies study NNS cord-335975-m6lkrehi 2662 9 be be VB cord-335975-m6lkrehi 2662 10 carried carry VBN cord-335975-m6lkrehi 2662 11 out out RP cord-335975-m6lkrehi 2662 12 and and CC cord-335975-m6lkrehi 2662 13 shared share VBD cord-335975-m6lkrehi 2662 14 experiences experience NNS cord-335975-m6lkrehi 2662 15 around around IN cord-335975-m6lkrehi 2662 16 the the DT cord-335975-m6lkrehi 2662 17 world world NN cord-335975-m6lkrehi 2662 18 on on IN cord-335975-m6lkrehi 2662 19 this this DT cord-335975-m6lkrehi 2662 20 drug drug NN cord-335975-m6lkrehi 2662 21 appear appear VBP cord-335975-m6lkrehi 2662 22 to to TO cord-335975-m6lkrehi 2662 23 be be VB cord-335975-m6lkrehi 2662 24 effective effective JJ cord-335975-m6lkrehi 2662 25 and and CC cord-335975-m6lkrehi 2662 26 prevent prevent VB cord-335975-m6lkrehi 2662 27 invasive invasive JJ cord-335975-m6lkrehi 2662 28 actions action NNS cord-335975-m6lkrehi 2662 29 in in IN cord-335975-m6lkrehi 2662 30 the the DT cord-335975-m6lkrehi 2662 31 therapeutic therapeutic JJ cord-335975-m6lkrehi 2662 32 arsenal arsenal NN cord-335975-m6lkrehi 2662 33 of of IN cord-335975-m6lkrehi 2662 34 postpartum postpartum NNP cord-335975-m6lkrehi 2662 35 heamorrhage heamorrhage NNP cord-335975-m6lkrehi 2662 36 . . . cord-335975-m6lkrehi 2663 1 Introduction introduction NN cord-335975-m6lkrehi 2663 2 : : : cord-335975-m6lkrehi 2663 3 Post post JJ cord-335975-m6lkrehi 2663 4 - - JJ cord-335975-m6lkrehi 2663 5 partum partum JJ cord-335975-m6lkrehi 2663 6 haemorrhage haemorrhage NN cord-335975-m6lkrehi 2663 7 ( ( -LRB- cord-335975-m6lkrehi 2663 8 PPH pph NN cord-335975-m6lkrehi 2663 9 ) ) -RRB- cord-335975-m6lkrehi 2663 10 is be VBZ cord-335975-m6lkrehi 2663 11 a a DT cord-335975-m6lkrehi 2663 12 life life NN cord-335975-m6lkrehi 2663 13 - - HYPH cord-335975-m6lkrehi 2663 14 threatening threaten VBG cord-335975-m6lkrehi 2663 15 complication complication NN cord-335975-m6lkrehi 2663 16 and and CC cord-335975-m6lkrehi 2663 17 remains remain VBZ cord-335975-m6lkrehi 2663 18 a a DT cord-335975-m6lkrehi 2663 19 leading leading JJ cord-335975-m6lkrehi 2663 20 cause cause NN cord-335975-m6lkrehi 2663 21 of of IN cord-335975-m6lkrehi 2663 22 maternal maternal JJ cord-335975-m6lkrehi 2663 23 morbidity morbidity NN cord-335975-m6lkrehi 2663 24 worldwide worldwide RB cord-335975-m6lkrehi 2663 25 . . . cord-335975-m6lkrehi 2664 1 The the DT cord-335975-m6lkrehi 2664 2 WOMAN WOMAN NNP cord-335975-m6lkrehi 2664 3 trial trial NN cord-335975-m6lkrehi 2664 4 * * NFP cord-335975-m6lkrehi 2664 5 estabished estabishe VBD cord-335975-m6lkrehi 2664 6 that that IN cord-335975-m6lkrehi 2664 7 early early JJ cord-335975-m6lkrehi 2664 8 administration administration NN cord-335975-m6lkrehi 2664 9 of of IN cord-335975-m6lkrehi 2664 10 Tranexamic Tranexamic NNP cord-335975-m6lkrehi 2664 11 Acid Acid NNP cord-335975-m6lkrehi 2664 12 ( ( -LRB- cord-335975-m6lkrehi 2664 13 TA TA NNP cord-335975-m6lkrehi 2664 14 ) ) -RRB- cord-335975-m6lkrehi 2664 15 reduces reduce VBZ cord-335975-m6lkrehi 2664 16 mortality mortality NN cord-335975-m6lkrehi 2664 17 due due IN cord-335975-m6lkrehi 2664 18 to to IN cord-335975-m6lkrehi 2664 19 the the DT cord-335975-m6lkrehi 2664 20 bleeding bleeding NN cord-335975-m6lkrehi 2664 21 in in IN cord-335975-m6lkrehi 2664 22 women woman NNS cord-335975-m6lkrehi 2664 23 with with IN cord-335975-m6lkrehi 2664 24 PPH pph NN cord-335975-m6lkrehi 2664 25 . . . cord-335975-m6lkrehi 2665 1 Our -PRON- PRP$ cord-335975-m6lkrehi 2665 2 study study NN cord-335975-m6lkrehi 2665 3 purpose purpose NN cord-335975-m6lkrehi 2665 4 was be VBD cord-335975-m6lkrehi 2665 5 to to TO cord-335975-m6lkrehi 2665 6 determine determine VB cord-335975-m6lkrehi 2665 7 the the DT cord-335975-m6lkrehi 2665 8 effects effect NNS cord-335975-m6lkrehi 2665 9 of of IN cord-335975-m6lkrehi 2665 10 early early JJ cord-335975-m6lkrehi 2665 11 administration administration NN cord-335975-m6lkrehi 2665 12 of of IN cord-335975-m6lkrehi 2665 13 TA TA NNP cord-335975-m6lkrehi 2665 14 and and CC cord-335975-m6lkrehi 2665 15 fibrinogen fibrinogen NN cord-335975-m6lkrehi 2665 16 concentrate concentrate VBP cord-335975-m6lkrehi 2665 17 on on IN cord-335975-m6lkrehi 2665 18 death death NN cord-335975-m6lkrehi 2665 19 , , , cord-335975-m6lkrehi 2665 20 hysterectomy hysterectomy NN cord-335975-m6lkrehi 2665 21 and and CC cord-335975-m6lkrehi 2665 22 transfusion transfusion NN cord-335975-m6lkrehi 2665 23 in in IN cord-335975-m6lkrehi 2665 24 women woman NNS cord-335975-m6lkrehi 2665 25 with with IN cord-335975-m6lkrehi 2665 26 severe severe JJ cord-335975-m6lkrehi 2665 27 PPH pph NN cord-335975-m6lkrehi 2665 28 . . . cord-335975-m6lkrehi 2666 1 Patients patient NNS cord-335975-m6lkrehi 2666 2 and and CC cord-335975-m6lkrehi 2666 3 methods method NNS cord-335975-m6lkrehi 2666 4 : : : cord-335975-m6lkrehi 2666 5 This this DT cord-335975-m6lkrehi 2666 6 retrospective retrospective JJ cord-335975-m6lkrehi 2666 7 , , , cord-335975-m6lkrehi 2666 8 monocentric monocentric JJ cord-335975-m6lkrehi 2666 9 study study NN cord-335975-m6lkrehi 2666 10 was be VBD cord-335975-m6lkrehi 2666 11 performed perform VBN cord-335975-m6lkrehi 2666 12 in in IN cord-335975-m6lkrehi 2666 13 a a DT cord-335975-m6lkrehi 2666 14 third third JJ cord-335975-m6lkrehi 2666 15 level level NN cord-335975-m6lkrehi 2666 16 Tunisian tunisian JJ cord-335975-m6lkrehi 2666 17 hospital hospital NN cord-335975-m6lkrehi 2666 18 providing provide VBG cord-335975-m6lkrehi 2666 19 healthcare healthcare NN cord-335975-m6lkrehi 2666 20 for for IN cord-335975-m6lkrehi 2666 21 more more JJR cord-335975-m6lkrehi 2666 22 than than IN cord-335975-m6lkrehi 2666 23 10000 10000 CD cord-335975-m6lkrehi 2666 24 pregnant pregnant JJ cord-335975-m6lkrehi 2666 25 women woman NNS cord-335975-m6lkrehi 2666 26 per per IN cord-335975-m6lkrehi 2666 27 year year NN cord-335975-m6lkrehi 2666 28 . . . cord-335975-m6lkrehi 2667 1 Were be VBD cord-335975-m6lkrehi 2667 2 included include VBN cord-335975-m6lkrehi 2667 3 in in IN cord-335975-m6lkrehi 2667 4 this this DT cord-335975-m6lkrehi 2667 5 study study NN cord-335975-m6lkrehi 2667 6 women woman NNS cord-335975-m6lkrehi 2667 7 with with IN cord-335975-m6lkrehi 2667 8 diagnosis diagnosis NN cord-335975-m6lkrehi 2667 9 of of IN cord-335975-m6lkrehi 2667 10 severe severe JJ cord-335975-m6lkrehi 2667 11 post post AFX cord-335975-m6lkrehi 2667 12 partum partum NN cord-335975-m6lkrehi 2667 13 haemorrhage haemorrhage NN cord-335975-m6lkrehi 2667 14 after after IN cord-335975-m6lkrehi 2667 15 a a DT cord-335975-m6lkrehi 2667 16 vaginal vaginal JJ cord-335975-m6lkrehi 2667 17 or or CC cord-335975-m6lkrehi 2667 18 caesarean caesarean JJ cord-335975-m6lkrehi 2667 19 delivery delivery NN cord-335975-m6lkrehi 2667 20 from from IN cord-335975-m6lkrehi 2667 21 2014 2014 CD cord-335975-m6lkrehi 2667 22 to to IN cord-335975-m6lkrehi 2667 23 2016 2016 CD cord-335975-m6lkrehi 2667 24 . . . cord-335975-m6lkrehi 2668 1 Patients patient NNS cord-335975-m6lkrehi 2668 2 who who WP cord-335975-m6lkrehi 2668 3 received receive VBD cord-335975-m6lkrehi 2668 4 TA TA NNP cord-335975-m6lkrehi 2668 5 and and CC cord-335975-m6lkrehi 2668 6 fibrinogen fibrinogen NN cord-335975-m6lkrehi 2668 7 concentrate concentrate NN cord-335975-m6lkrehi 2668 8 were be VBD cord-335975-m6lkrehi 2668 9 assessed assess VBN cord-335975-m6lkrehi 2668 10 in in IN cord-335975-m6lkrehi 2668 11 group group NN cord-335975-m6lkrehi 2668 12 1(G1 1(g1 CD cord-335975-m6lkrehi 2668 13 ) ) -RRB- cord-335975-m6lkrehi 2668 14 and and CC cord-335975-m6lkrehi 2668 15 who who WP cord-335975-m6lkrehi 2668 16 not not RB cord-335975-m6lkrehi 2668 17 in in IN cord-335975-m6lkrehi 2668 18 group group NN cord-335975-m6lkrehi 2668 19 2(G2 2(g2 CD cord-335975-m6lkrehi 2668 20 ) ) -RRB- cord-335975-m6lkrehi 2668 21 . . . cord-335975-m6lkrehi 2669 1 Results result NNS cord-335975-m6lkrehi 2669 2 : : : cord-335975-m6lkrehi 2670 1 The the DT cord-335975-m6lkrehi 2670 2 incidence incidence NN cord-335975-m6lkrehi 2670 3 of of IN cord-335975-m6lkrehi 2670 4 severe severe JJ cord-335975-m6lkrehi 2670 5 PPH pph NN cord-335975-m6lkrehi 2670 6 was be VBD cord-335975-m6lkrehi 2670 7 35/10000 35/10000 CD cord-335975-m6lkrehi 2670 8 deliveries delivery NNS cord-335975-m6lkrehi 2670 9 . . . cord-335975-m6lkrehi 2671 1 166 166 CD cord-335975-m6lkrehi 2671 2 women woman NNS cord-335975-m6lkrehi 2671 3 were be VBD cord-335975-m6lkrehi 2671 4 retained retain VBN cord-335975-m6lkrehi 2671 5 for for IN cord-335975-m6lkrehi 2671 6 data datum NNS cord-335975-m6lkrehi 2671 7 analysis analysis NN cord-335975-m6lkrehi 2671 8 G1 G1 NNP cord-335975-m6lkrehi 2671 9 ( ( -LRB- cord-335975-m6lkrehi 2671 10 n n NN cord-335975-m6lkrehi 2671 11 = = SYM cord-335975-m6lkrehi 2671 12 109 109 CD cord-335975-m6lkrehi 2671 13 ) ) -RRB- cord-335975-m6lkrehi 2671 14 , , , cord-335975-m6lkrehi 2671 15 G2 G2 NNP cord-335975-m6lkrehi 2671 16 ( ( -LRB- cord-335975-m6lkrehi 2671 17 n n NN cord-335975-m6lkrehi 2671 18 = = SYM cord-335975-m6lkrehi 2671 19 57 57 CD cord-335975-m6lkrehi 2671 20 ) ) -RRB- cord-335975-m6lkrehi 2671 21 . . . cord-335975-m6lkrehi 2672 1 Anthropomorphic anthropomorphic JJ cord-335975-m6lkrehi 2672 2 and and CC cord-335975-m6lkrehi 2672 3 obstetrics obstetric NNS cord-335975-m6lkrehi 2672 4 characteristics characteristic NNS cord-335975-m6lkrehi 2672 5 were be VBD cord-335975-m6lkrehi 2672 6 not not RB cord-335975-m6lkrehi 2672 7 significantly significantly RB cord-335975-m6lkrehi 2672 8 different different JJ cord-335975-m6lkrehi 2672 9 between between IN cord-335975-m6lkrehi 2672 10 the the DT cord-335975-m6lkrehi 2672 11 two two CD cord-335975-m6lkrehi 2672 12 groups group NNS cord-335975-m6lkrehi 2672 13 . . . cord-335975-m6lkrehi 2673 1 There there EX cord-335975-m6lkrehi 2673 2 was be VBD cord-335975-m6lkrehi 2673 3 a a DT cord-335975-m6lkrehi 2673 4 significant significant JJ cord-335975-m6lkrehi 2673 5 difference difference NN cord-335975-m6lkrehi 2673 6 between between IN cord-335975-m6lkrehi 2673 7 the the DT cord-335975-m6lkrehi 2673 8 two two CD cord-335975-m6lkrehi 2673 9 groups group NNS cord-335975-m6lkrehi 2673 10 regarding regard VBG cord-335975-m6lkrehi 2673 11 to to IN cord-335975-m6lkrehi 2673 12 transfused transfused JJ cord-335975-m6lkrehi 2673 13 units unit NNS cord-335975-m6lkrehi 2673 14 of of IN cord-335975-m6lkrehi 2673 15 red red JJ cord-335975-m6lkrehi 2673 16 blood blood NN cord-335975-m6lkrehi 2673 17 cells cell NNS cord-335975-m6lkrehi 2673 18 however however RB cord-335975-m6lkrehi 2673 19 , , , cord-335975-m6lkrehi 2673 20 no no DT cord-335975-m6lkrehi 2673 21 difference difference NN cord-335975-m6lkrehi 2673 22 in in IN cord-335975-m6lkrehi 2673 23 term term NN cord-335975-m6lkrehi 2673 24 of of IN cord-335975-m6lkrehi 2673 25 the the DT cord-335975-m6lkrehi 2673 26 use use NN cord-335975-m6lkrehi 2673 27 of of IN cord-335975-m6lkrehi 2673 28 frozen frozen JJ cord-335975-m6lkrehi 2673 29 plasma plasma NN cord-335975-m6lkrehi 2673 30 and and CC cord-335975-m6lkrehi 2673 31 platelets platelet NNS cord-335975-m6lkrehi 2673 32 concentrates concentrate NNS cord-335975-m6lkrehi 2673 33 was be VBD cord-335975-m6lkrehi 2673 34 observed observe VBN cord-335975-m6lkrehi 2673 35 . . . cord-335975-m6lkrehi 2674 1 Perioperative perioperative JJ cord-335975-m6lkrehi 2674 2 hemoglobin hemoglobin NN cord-335975-m6lkrehi 2674 3 nadir nadir NN cord-335975-m6lkrehi 2674 4 was be VBD cord-335975-m6lkrehi 2674 5 significantly significantly RB cord-335975-m6lkrehi 2674 6 higher high JJR cord-335975-m6lkrehi 2674 7 in in IN cord-335975-m6lkrehi 2674 8 G g NN cord-335975-m6lkrehi 2674 9 1 1 CD cord-335975-m6lkrehi 2674 10 . . . cord-335975-m6lkrehi 2675 1 The the DT cord-335975-m6lkrehi 2675 2 frequency frequency NN cord-335975-m6lkrehi 2675 3 of of IN cord-335975-m6lkrehi 2675 4 hysterectomy hysterectomy NN cord-335975-m6lkrehi 2675 5 and and CC cord-335975-m6lkrehi 2675 6 pelvic pelvic JJ cord-335975-m6lkrehi 2675 7 packing packing NN cord-335975-m6lkrehi 2675 8 were be VBD cord-335975-m6lkrehi 2675 9 higher high JJR cord-335975-m6lkrehi 2675 10 in in IN cord-335975-m6lkrehi 2675 11 G2 G2 NNP cord-335975-m6lkrehi 2675 12 ( ( -LRB- cord-335975-m6lkrehi 2675 13 Table Table NNP cord-335975-m6lkrehi 2675 14 1 1 CD cord-335975-m6lkrehi 2675 15 ) ) -RRB- cord-335975-m6lkrehi 2675 16 . . . cord-335975-m6lkrehi 2676 1 No no DT cord-335975-m6lkrehi 2676 2 thromboembolic thromboembolic JJ cord-335975-m6lkrehi 2676 3 events event NNS cord-335975-m6lkrehi 2676 4 and and CC cord-335975-m6lkrehi 2676 5 no no DT cord-335975-m6lkrehi 2676 6 haemorrhage haemorrhage NN cord-335975-m6lkrehi 2676 7 related relate VBN cord-335975-m6lkrehi 2676 8 mortality mortality NN cord-335975-m6lkrehi 2676 9 were be VBD cord-335975-m6lkrehi 2676 10 observed observe VBN cord-335975-m6lkrehi 2676 11 in in IN cord-335975-m6lkrehi 2676 12 the the DT cord-335975-m6lkrehi 2676 13 two two CD cord-335975-m6lkrehi 2676 14 groups group NNS cord-335975-m6lkrehi 2676 15 . . . cord-335975-m6lkrehi 2677 1 Conclusion conclusion NN cord-335975-m6lkrehi 2677 2 : : : cord-335975-m6lkrehi 2678 1 In in IN cord-335975-m6lkrehi 2678 2 this this DT cord-335975-m6lkrehi 2678 3 retrospective retrospective JJ cord-335975-m6lkrehi 2678 4 study study NN cord-335975-m6lkrehi 2678 5 , , , cord-335975-m6lkrehi 2678 6 early early JJ cord-335975-m6lkrehi 2678 7 administration administration NN cord-335975-m6lkrehi 2678 8 of of IN cord-335975-m6lkrehi 2678 9 tranexamic tranexamic NNP cord-335975-m6lkrehi 2678 10 acid acid NN cord-335975-m6lkrehi 2678 11 and and CC cord-335975-m6lkrehi 2678 12 fibrinogen fibrinogen NN cord-335975-m6lkrehi 2678 13 reduces reduce VBZ cord-335975-m6lkrehi 2678 14 risk risk NN cord-335975-m6lkrehi 2678 15 of of IN cord-335975-m6lkrehi 2678 16 hysterectomy hysterectomy NN cord-335975-m6lkrehi 2678 17 transfusion transfusion NN cord-335975-m6lkrehi 2678 18 . . . cord-335975-m6lkrehi 2679 1 These these DT cord-335975-m6lkrehi 2679 2 encouraging encouraging JJ cord-335975-m6lkrehi 2679 3 results result NNS cord-335975-m6lkrehi 2679 4 strongly strongly RB cord-335975-m6lkrehi 2679 5 support support VBP cord-335975-m6lkrehi 2679 6 the the DT cord-335975-m6lkrehi 2679 7 need need NN cord-335975-m6lkrehi 2679 8 for for IN cord-335975-m6lkrehi 2679 9 a a DT cord-335975-m6lkrehi 2679 10 large large JJ cord-335975-m6lkrehi 2679 11 , , , cord-335975-m6lkrehi 2679 12 international international JJ cord-335975-m6lkrehi 2679 13 , , , cord-335975-m6lkrehi 2679 14 double double JJ cord-335975-m6lkrehi 2679 15 - - HYPH cord-335975-m6lkrehi 2679 16 blind blind JJ cord-335975-m6lkrehi 2679 17 study study NN cord-335975-m6lkrehi 2679 18 to to TO cord-335975-m6lkrehi 2679 19 investigate investigate VB cord-335975-m6lkrehi 2679 20 the the DT cord-335975-m6lkrehi 2679 21 potential potential NN cord-335975-m6lkrehi 2679 22 of of IN cord-335975-m6lkrehi 2679 23 the the DT cord-335975-m6lkrehi 2679 24 association association NN cord-335975-m6lkrehi 2679 25 " " `` cord-335975-m6lkrehi 2679 26 TA TA NNP cord-335975-m6lkrehi 2679 27 - - HYPH cord-335975-m6lkrehi 2679 28 Fibrinogen Fibrinogen NNP cord-335975-m6lkrehi 2679 29 concentrate concentrate NN cord-335975-m6lkrehi 2679 30 " " '' cord-335975-m6lkrehi 2679 31 to to TO cord-335975-m6lkrehi 2679 32 reduce reduce VB cord-335975-m6lkrehi 2679 33 maternal maternal JJ cord-335975-m6lkrehi 2679 34 haemorrhage haemorrhage NN cord-335975-m6lkrehi 2679 35 related relate VBN cord-335975-m6lkrehi 2679 36 morbidity morbidity NN cord-335975-m6lkrehi 2679 37 and and CC cord-335975-m6lkrehi 2679 38 mortality mortality NN cord-335975-m6lkrehi 2679 39 . . . cord-335975-m6lkrehi 2680 1 Introduction introduction NN cord-335975-m6lkrehi 2680 2 : : : cord-335975-m6lkrehi 2680 3 Immunodeficiency Immunodeficiency NNP cord-335975-m6lkrehi 2680 4 , , , cord-335975-m6lkrehi 2680 5 acquired acquire VBN cord-335975-m6lkrehi 2680 6 or or CC cord-335975-m6lkrehi 2680 7 congenital congenital JJ cord-335975-m6lkrehi 2680 8 , , , cord-335975-m6lkrehi 2680 9 is be VBZ cord-335975-m6lkrehi 2680 10 the the DT cord-335975-m6lkrehi 2680 11 first first JJ cord-335975-m6lkrehi 2680 12 comorbidity comorbidity NN cord-335975-m6lkrehi 2680 13 associated associate VBN cord-335975-m6lkrehi 2680 14 with with IN cord-335975-m6lkrehi 2680 15 poor poor JJ cord-335975-m6lkrehi 2680 16 outcome outcome NN cord-335975-m6lkrehi 2680 17 in in IN cord-335975-m6lkrehi 2680 18 pediatric pediatric JJ cord-335975-m6lkrehi 2680 19 patients patient NNS cord-335975-m6lkrehi 2680 20 with with IN cord-335975-m6lkrehi 2680 21 acute acute JJ cord-335975-m6lkrehi 2680 22 respiratory respiratory JJ cord-335975-m6lkrehi 2680 23 distress distress NN cord-335975-m6lkrehi 2680 24 syndrome syndrome NN cord-335975-m6lkrehi 2680 25 1(ARDS 1(ards CD cord-335975-m6lkrehi 2680 26 ) ) -RRB- cord-335975-m6lkrehi 2680 27 . . . cord-335975-m6lkrehi 2681 1 The the DT cord-335975-m6lkrehi 2681 2 aim aim NN cord-335975-m6lkrehi 2681 3 of of IN cord-335975-m6lkrehi 2681 4 this this DT cord-335975-m6lkrehi 2681 5 study study NN cord-335975-m6lkrehi 2681 6 was be VBD cord-335975-m6lkrehi 2681 7 to to TO cord-335975-m6lkrehi 2681 8 describe describe VB cord-335975-m6lkrehi 2681 9 outcome outcome NN cord-335975-m6lkrehi 2681 10 of of IN cord-335975-m6lkrehi 2681 11 pediatric pediatric JJ cord-335975-m6lkrehi 2681 12 patient patient NN cord-335975-m6lkrehi 2681 13 with with IN cord-335975-m6lkrehi 2681 14 hematologic hematologic JJ cord-335975-m6lkrehi 2681 15 disease disease NN cord-335975-m6lkrehi 2681 16 hospitalized hospitalize VBN cord-335975-m6lkrehi 2681 17 in in IN cord-335975-m6lkrehi 2681 18 our -PRON- PRP$ cord-335975-m6lkrehi 2681 19 intensive intensive JJ cord-335975-m6lkrehi 2681 20 care care NN cord-335975-m6lkrehi 2681 21 unit unit NN cord-335975-m6lkrehi 2681 22 for for IN cord-335975-m6lkrehi 2681 23 respiratory respiratory JJ cord-335975-m6lkrehi 2681 24 failure failure NN cord-335975-m6lkrehi 2681 25 and and CC cord-335975-m6lkrehi 2681 26 to to TO cord-335975-m6lkrehi 2681 27 investigate investigate VB cord-335975-m6lkrehi 2681 28 the the DT cord-335975-m6lkrehi 2681 29 clinical clinical JJ cord-335975-m6lkrehi 2681 30 variables variable NNS cord-335975-m6lkrehi 2681 31 associated associate VBN cord-335975-m6lkrehi 2681 32 with with IN cord-335975-m6lkrehi 2681 33 mortality mortality NN cord-335975-m6lkrehi 2681 34 . . . cord-335975-m6lkrehi 2682 1 Patients patient NNS cord-335975-m6lkrehi 2682 2 and and CC cord-335975-m6lkrehi 2682 3 methods method NNS cord-335975-m6lkrehi 2683 1 : : : cord-335975-m6lkrehi 2683 2 It -PRON- PRP cord-335975-m6lkrehi 2683 3 was be VBD cord-335975-m6lkrehi 2683 4 a a DT cord-335975-m6lkrehi 2683 5 retrospective retrospective JJ cord-335975-m6lkrehi 2683 6 monocentric monocentric JJ cord-335975-m6lkrehi 2683 7 descriptive descriptive JJ cord-335975-m6lkrehi 2683 8 study study NN cord-335975-m6lkrehi 2683 9 including include VBG cord-335975-m6lkrehi 2683 10 all all DT cord-335975-m6lkrehi 2683 11 immunodeficient immunodeficient JJ cord-335975-m6lkrehi 2683 12 pediatric pediatric JJ cord-335975-m6lkrehi 2683 13 patient patient NN cord-335975-m6lkrehi 2683 14 ( ( -LRB- cord-335975-m6lkrehi 2683 15 malignant malignant JJ cord-335975-m6lkrehi 2683 16 hemopathy hemopathy NNP cord-335975-m6lkrehi 2683 17 , , , cord-335975-m6lkrehi 2683 18 congenital congenital JJ cord-335975-m6lkrehi 2683 19 immunodeficiency immunodeficiency NN cord-335975-m6lkrehi 2683 20 , , , cord-335975-m6lkrehi 2683 21 bone bone NN cord-335975-m6lkrehi 2683 22 marrow marrow NN cord-335975-m6lkrehi 2683 23 transplanta transplanta NN cord-335975-m6lkrehi 2683 24 - - HYPH cord-335975-m6lkrehi 2683 25 tion tion NN cord-335975-m6lkrehi 2683 26 … … NFP cord-335975-m6lkrehi 2683 27 ) ) -RRB- cord-335975-m6lkrehi 2683 28 from from IN cord-335975-m6lkrehi 2683 29 hematology hematology NN cord-335975-m6lkrehi 2683 30 hospitalized hospitalize VBN cord-335975-m6lkrehi 2683 31 in in IN cord-335975-m6lkrehi 2683 32 our -PRON- PRP$ cord-335975-m6lkrehi 2683 33 14 14 CD cord-335975-m6lkrehi 2683 34 beds bed NNS cord-335975-m6lkrehi 2683 35 pediatric pediatric JJ cord-335975-m6lkrehi 2683 36 intensive intensive JJ cord-335975-m6lkrehi 2683 37 care care NN cord-335975-m6lkrehi 2683 38 unit unit NN cord-335975-m6lkrehi 2683 39 with with IN cord-335975-m6lkrehi 2683 40 the the DT cord-335975-m6lkrehi 2683 41 diagnosis diagnosis NN cord-335975-m6lkrehi 2683 42 of of IN cord-335975-m6lkrehi 2683 43 respiratory respiratory JJ cord-335975-m6lkrehi 2683 44 failure failure NN cord-335975-m6lkrehi 2683 45 between between IN cord-335975-m6lkrehi 2683 46 January January NNP cord-335975-m6lkrehi 2683 47 2003 2003 CD cord-335975-m6lkrehi 2683 48 and and CC cord-335975-m6lkrehi 2683 49 February February NNP cord-335975-m6lkrehi 2683 50 2017 2017 CD cord-335975-m6lkrehi 2683 51 . . . cord-335975-m6lkrehi 2684 1 Results result NNS cord-335975-m6lkrehi 2684 2 : : : cord-335975-m6lkrehi 2685 1 Fifty fifty CD cord-335975-m6lkrehi 2685 2 one one CD cord-335975-m6lkrehi 2685 3 patients patient NNS cord-335975-m6lkrehi 2685 4 were be VBD cord-335975-m6lkrehi 2685 5 included include VBN cord-335975-m6lkrehi 2685 6 corresponding correspond VBG cord-335975-m6lkrehi 2685 7 to to IN cord-335975-m6lkrehi 2685 8 53 53 CD cord-335975-m6lkrehi 2685 9 admissions admission NNS cord-335975-m6lkrehi 2685 10 . . . cord-335975-m6lkrehi 2686 1 Nighty nighty NN cord-335975-m6lkrehi 2686 2 percent percent NN cord-335975-m6lkrehi 2686 3 of of IN cord-335975-m6lkrehi 2686 4 the the DT cord-335975-m6lkrehi 2686 5 patients patient NNS cord-335975-m6lkrehi 2686 6 met meet VBD cord-335975-m6lkrehi 2686 7 criteria criterion NNS cord-335975-m6lkrehi 2686 8 for for IN cord-335975-m6lkrehi 2686 9 pediatric pediatric JJ cord-335975-m6lkrehi 2686 10 ARDS-67 ards-67 CD cord-335975-m6lkrehi 2686 11 % % NN cord-335975-m6lkrehi 2686 12 were be VBD cord-335975-m6lkrehi 2686 13 severe severe JJ cord-335975-m6lkrehi 2686 14 , , , cord-335975-m6lkrehi 2686 15 15 15 CD cord-335975-m6lkrehi 2686 16 % % NN cord-335975-m6lkrehi 2686 17 moderate moderate JJ cord-335975-m6lkrehi 2686 18 and and CC cord-335975-m6lkrehi 2686 19 2 2 CD cord-335975-m6lkrehi 2686 20 % % NN cord-335975-m6lkrehi 2686 21 mild mild JJ cord-335975-m6lkrehi 2686 22 . . . cord-335975-m6lkrehi 2687 1 Extracorporeal extracorporeal JJ cord-335975-m6lkrehi 2687 2 circulation circulation NN cord-335975-m6lkrehi 2687 3 ( ( -LRB- cord-335975-m6lkrehi 2687 4 ECC ECC NNP cord-335975-m6lkrehi 2687 5 ) ) -RRB- cord-335975-m6lkrehi 2687 6 was be VBD cord-335975-m6lkrehi 2687 7 needed need VBN cord-335975-m6lkrehi 2687 8 for for IN cord-335975-m6lkrehi 2687 9 7 7 CD cord-335975-m6lkrehi 2687 10 patients patient NNS cord-335975-m6lkrehi 2687 11 . . . cord-335975-m6lkrehi 2688 1 Global global JJ cord-335975-m6lkrehi 2688 2 mortality mortality NN cord-335975-m6lkrehi 2688 3 rate rate NN cord-335975-m6lkrehi 2688 4 at at IN cord-335975-m6lkrehi 2688 5 PICU PICU NNP cord-335975-m6lkrehi 2688 6 discharge discharge NN cord-335975-m6lkrehi 2688 7 was be VBD cord-335975-m6lkrehi 2688 8 47 47 CD cord-335975-m6lkrehi 2688 9 % % NN cord-335975-m6lkrehi 2688 10 . . . cord-335975-m6lkrehi 2689 1 Twenty twenty CD cord-335975-m6lkrehi 2689 2 four four CD cord-335975-m6lkrehi 2689 3 patients patient NNS cord-335975-m6lkrehi 2689 4 ( ( -LRB- cord-335975-m6lkrehi 2689 5 45 45 CD cord-335975-m6lkrehi 2689 6 % % NN cord-335975-m6lkrehi 2689 7 ) ) -RRB- cord-335975-m6lkrehi 2689 8 received receive VBD cord-335975-m6lkrehi 2689 9 noninvasive noninvasive JJ cord-335975-m6lkrehi 2689 10 ventilation ventilation NN cord-335975-m6lkrehi 2689 11 ( ( -LRB- cord-335975-m6lkrehi 2689 12 NIV NIV NNP cord-335975-m6lkrehi 2689 13 ) ) -RRB- cord-335975-m6lkrehi 2689 14 . . . cord-335975-m6lkrehi 2690 1 Height height NN cord-335975-m6lkrehi 2690 2 of of IN cord-335975-m6lkrehi 2690 3 them -PRON- PRP cord-335975-m6lkrehi 2690 4 ( ( -LRB- cord-335975-m6lkrehi 2690 5 33 33 CD cord-335975-m6lkrehi 2690 6 % % NN cord-335975-m6lkrehi 2690 7 ) ) -RRB- cord-335975-m6lkrehi 2690 8 did do VBD cord-335975-m6lkrehi 2690 9 not not RB cord-335975-m6lkrehi 2690 10 need need VB cord-335975-m6lkrehi 2690 11 invasive invasive JJ cord-335975-m6lkrehi 2690 12 mechanical mechanical JJ cord-335975-m6lkrehi 2690 13 ventilation ventilation NN cord-335975-m6lkrehi 2690 14 ( ( -LRB- cord-335975-m6lkrehi 2690 15 IMV IMV NNP cord-335975-m6lkrehi 2690 16 ) ) -RRB- cord-335975-m6lkrehi 2690 17 . . . cord-335975-m6lkrehi 2691 1 In in IN cord-335975-m6lkrehi 2691 2 patients patient NNS cord-335975-m6lkrehi 2691 3 who who WP cord-335975-m6lkrehi 2691 4 received receive VBD cord-335975-m6lkrehi 2691 5 IMV IMV NNP cord-335975-m6lkrehi 2691 6 , , , cord-335975-m6lkrehi 2691 7 mortality mortality NN cord-335975-m6lkrehi 2691 8 rate rate NN cord-335975-m6lkrehi 2691 9 was be VBD cord-335975-m6lkrehi 2691 10 significantly significantly RB cord-335975-m6lkrehi 2691 11 higher high JJR cord-335975-m6lkrehi 2692 1 if if IN cord-335975-m6lkrehi 2692 2 patients patient NNS cord-335975-m6lkrehi 2692 3 received receive VBN cord-335975-m6lkrehi 2692 4 before before IN cord-335975-m6lkrehi 2692 5 NIV NIV NNP cord-335975-m6lkrehi 2692 6 ( ( -LRB- cord-335975-m6lkrehi 2692 7 81 81 CD cord-335975-m6lkrehi 2692 8 vs. vs. NN cord-335975-m6lkrehi 2692 9 41 41 CD cord-335975-m6lkrehi 2692 10 % % NN cord-335975-m6lkrehi 2692 11 ) ) -RRB- cord-335975-m6lkrehi 2692 12 p p NN cord-335975-m6lkrehi 2692 13 = = SYM cord-335975-m6lkrehi 2692 14 0.001 0.001 CD cord-335975-m6lkrehi 2692 15 . . . cord-335975-m6lkrehi 2693 1 All all DT cord-335975-m6lkrehi 2693 2 patients patient NNS cord-335975-m6lkrehi 2693 3 who who WP cord-335975-m6lkrehi 2693 4 needed need VBD cord-335975-m6lkrehi 2693 5 IMV IMV NNP cord-335975-m6lkrehi 2693 6 after after IN cord-335975-m6lkrehi 2693 7 more more JJR cord-335975-m6lkrehi 2693 8 than than IN cord-335975-m6lkrehi 2693 9 24 24 CD cord-335975-m6lkrehi 2693 10 h h NN cord-335975-m6lkrehi 2693 11 of of IN cord-335975-m6lkrehi 2693 12 NIV NIV NNP cord-335975-m6lkrehi 2693 13 died die VBD cord-335975-m6lkrehi 2693 14 ( ( -LRB- cord-335975-m6lkrehi 2693 15 n n NN cord-335975-m6lkrehi 2693 16 = = SYM cord-335975-m6lkrehi 2693 17 3 3 CD cord-335975-m6lkrehi 2693 18 ) ) -RRB- cord-335975-m6lkrehi 2693 19 . . . cord-335975-m6lkrehi 2694 1 Mortality mortality NN cord-335975-m6lkrehi 2694 2 was be VBD cord-335975-m6lkrehi 2694 3 higher high JJR cord-335975-m6lkrehi 2694 4 in in IN cord-335975-m6lkrehi 2694 5 children child NNS cord-335975-m6lkrehi 2694 6 with with IN cord-335975-m6lkrehi 2694 7 griffon griffon NNP cord-335975-m6lkrehi 2694 8 versus versus IN cord-335975-m6lkrehi 2694 9 host host NN cord-335975-m6lkrehi 2694 10 disease disease NN cord-335975-m6lkrehi 2694 11 ( ( -LRB- cord-335975-m6lkrehi 2694 12 80 80 CD cord-335975-m6lkrehi 2694 13 vs. vs. NN cord-335975-m6lkrehi 2694 14 40 40 CD cord-335975-m6lkrehi 2694 15 % % NN cord-335975-m6lkrehi 2694 16 p p NN cord-335975-m6lkrehi 2694 17 = = SYM cord-335975-m6lkrehi 2694 18 0.04 0.04 CD cord-335975-m6lkrehi 2694 19 ) ) -RRB- cord-335975-m6lkrehi 2694 20 . . . cord-335975-m6lkrehi 2695 1 Mortality mortality NN cord-335975-m6lkrehi 2695 2 of of IN cord-335975-m6lkrehi 2695 3 patients patient NNS cord-335975-m6lkrehi 2695 4 receiving receive VBG cord-335975-m6lkrehi 2695 5 ECC ECC NNP cord-335975-m6lkrehi 2695 6 and and CC cord-335975-m6lkrehi 2695 7 renal renal JJ cord-335975-m6lkrehi 2695 8 replacement replacement NN cord-335975-m6lkrehi 2695 9 therapy therapy NN cord-335975-m6lkrehi 2695 10 ( ( -LRB- cord-335975-m6lkrehi 2695 11 RTT RTT NNP cord-335975-m6lkrehi 2695 12 ) ) -RRB- cord-335975-m6lkrehi 2695 13 was be VBD cord-335975-m6lkrehi 2695 14 respectively respectively RB cord-335975-m6lkrehi 2695 15 71 71 CD cord-335975-m6lkrehi 2695 16 and and CC cord-335975-m6lkrehi 2695 17 80 80 CD cord-335975-m6lkrehi 2695 18 % % NN cord-335975-m6lkrehi 2695 19 . . . cord-335975-m6lkrehi 2696 1 Conclusion conclusion NN cord-335975-m6lkrehi 2696 2 : : : cord-335975-m6lkrehi 2697 1 In in IN cord-335975-m6lkrehi 2697 2 our -PRON- PRP$ cord-335975-m6lkrehi 2697 3 study study NN cord-335975-m6lkrehi 2697 4 , , , cord-335975-m6lkrehi 2697 5 most most JJS cord-335975-m6lkrehi 2697 6 of of IN cord-335975-m6lkrehi 2697 7 the the DT cord-335975-m6lkrehi 2697 8 patients patient NNS cord-335975-m6lkrehi 2697 9 hospitalized hospitalize VBN cord-335975-m6lkrehi 2697 10 for for IN cord-335975-m6lkrehi 2697 11 respiratory respiratory JJ cord-335975-m6lkrehi 2697 12 failure failure NN cord-335975-m6lkrehi 2697 13 met meet VBD cord-335975-m6lkrehi 2697 14 criteria criterion NNS cord-335975-m6lkrehi 2697 15 for for IN cord-335975-m6lkrehi 2697 16 pediatric pediatric JJ cord-335975-m6lkrehi 2697 17 ARDS ARDS NNP cord-335975-m6lkrehi 2697 18 . . . cord-335975-m6lkrehi 2698 1 If if IN cord-335975-m6lkrehi 2698 2 NIV NIV NNP cord-335975-m6lkrehi 2698 3 decrease decrease NN cord-335975-m6lkrehi 2698 4 IMV IMV NNP cord-335975-m6lkrehi 2698 5 requirement requirement NN cord-335975-m6lkrehi 2698 6 , , , cord-335975-m6lkrehi 2698 7 it -PRON- PRP cord-335975-m6lkrehi 2698 8 could could MD cord-335975-m6lkrehi 2698 9 be be VB cord-335975-m6lkrehi 2698 10 associated associate VBN cord-335975-m6lkrehi 2698 11 with with IN cord-335975-m6lkrehi 2698 12 higher high JJR cord-335975-m6lkrehi 2698 13 mortality mortality NN cord-335975-m6lkrehi 2698 14 rate rate NN cord-335975-m6lkrehi 2698 15 in in IN cord-335975-m6lkrehi 2698 16 case case NN cord-335975-m6lkrehi 2698 17 of of IN cord-335975-m6lkrehi 2698 18 failure failure NN cord-335975-m6lkrehi 2698 19 . . . cord-335975-m6lkrehi 2699 1 This this DT cord-335975-m6lkrehi 2699 2 result result NN cord-335975-m6lkrehi 2699 3 support support NN cord-335975-m6lkrehi 2699 4 recent recent JJ cord-335975-m6lkrehi 2699 5 recommendation2 recommendation2 NN cord-335975-m6lkrehi 2699 6 that that DT cord-335975-m6lkrehi 2699 7 immunodeficiency immunodeficiency NN cord-335975-m6lkrehi 2699 8 is be VBZ cord-335975-m6lkrehi 2699 9 not not RB cord-335975-m6lkrehi 2699 10 a a DT cord-335975-m6lkrehi 2699 11 sufficient sufficient JJ cord-335975-m6lkrehi 2699 12 criteria criterion NNS cord-335975-m6lkrehi 2699 13 to to IN cord-335975-m6lkrehi 2699 14 delayed delay VBN cord-335975-m6lkrehi 2699 15 IMV IMV NNP cord-335975-m6lkrehi 2699 16 . . . cord-335975-m6lkrehi 2699 17 . . . cord-335975-m6lkrehi 2700 1 Flow flow NN cord-335975-m6lkrehi 2700 2 and and CC cord-335975-m6lkrehi 2700 3 airway airway NN cord-335975-m6lkrehi 2700 4 pressure pressure NN cord-335975-m6lkrehi 2700 5 were be VBD cord-335975-m6lkrehi 2700 6 recorded record VBN cord-335975-m6lkrehi 2700 7 at at IN cord-335975-m6lkrehi 2700 8 the the DT cord-335975-m6lkrehi 2700 9 ASL ASL NNP cord-335975-m6lkrehi 2700 10 inlet inlet NN cord-335975-m6lkrehi 2700 11 and and CC cord-335975-m6lkrehi 2700 12 mouth mouth NN cord-335975-m6lkrehi 2700 13 pressure pressure NN cord-335975-m6lkrehi 2700 14 into into IN cord-335975-m6lkrehi 2700 15 the the DT cord-335975-m6lkrehi 2700 16 manikin manikin NN cord-335975-m6lkrehi 2700 17 mouth mouth NN cord-335975-m6lkrehi 2700 18 . . . cord-335975-m6lkrehi 2701 1 We -PRON- PRP cord-335975-m6lkrehi 2701 2 defined define VBD cord-335975-m6lkrehi 2701 3 " " `` cord-335975-m6lkrehi 2701 4 device device NN cord-335975-m6lkrehi 2701 5 driving drive VBG cord-335975-m6lkrehi 2701 6 pressure pressure NN cord-335975-m6lkrehi 2701 7 " " '' cord-335975-m6lkrehi 2701 8 as as IN cord-335975-m6lkrehi 2701 9 the the DT cord-335975-m6lkrehi 2701 10 peak peak JJ cord-335975-m6lkrehi 2701 11 mouth mouth NNP cord-335975-m6lkrehi 2701 12 pressure pressure NN cord-335975-m6lkrehi 2701 13 minus minus IN cord-335975-m6lkrehi 2701 14 the the DT cord-335975-m6lkrehi 2701 15 tele tele NNP cord-335975-m6lkrehi 2701 16 - - HYPH cord-335975-m6lkrehi 2701 17 expiratory expiratory JJ cord-335975-m6lkrehi 2701 18 mouth mouth NN cord-335975-m6lkrehi 2701 19 pressure pressure NN cord-335975-m6lkrehi 2701 20 . . . cord-335975-m6lkrehi 2702 1 Continuous continuous JJ cord-335975-m6lkrehi 2702 2 data datum NNS cord-335975-m6lkrehi 2702 3 are be VBP cord-335975-m6lkrehi 2702 4 reported report VBN cord-335975-m6lkrehi 2702 5 as as IN cord-335975-m6lkrehi 2702 6 mean mean JJ cord-335975-m6lkrehi 2702 7 ± ± NNP cord-335975-m6lkrehi 2702 8 SD SD NNP cord-335975-m6lkrehi 2702 9 . . . cord-335975-m6lkrehi 2703 1 Results result NNS cord-335975-m6lkrehi 2703 2 : : : cord-335975-m6lkrehi 2704 1 As as IN cord-335975-m6lkrehi 2704 2 compared compare VBN cord-335975-m6lkrehi 2704 3 to to IN cord-335975-m6lkrehi 2704 4 the the DT cord-335975-m6lkrehi 2704 5 oxygen oxygen NN cord-335975-m6lkrehi 2704 6 mask mask NN cord-335975-m6lkrehi 2704 7 , , , cord-335975-m6lkrehi 2704 8 Vt Vt NNP cord-335975-m6lkrehi 2704 9 increased increase VBD cord-335975-m6lkrehi 2704 10 significantly significantly RB cord-335975-m6lkrehi 2704 11 with with IN cord-335975-m6lkrehi 2704 12 M M NNP cord-335975-m6lkrehi 2704 13 - - HYPH cord-335975-m6lkrehi 2704 14 NIV NIV NNP cord-335975-m6lkrehi 2704 15 and and CC cord-335975-m6lkrehi 2704 16 H H NNP cord-335975-m6lkrehi 2704 17 - - HYPH cord-335975-m6lkrehi 2704 18 NIV NIV NNP cord-335975-m6lkrehi 2704 19 whatever whatever WDT cord-335975-m6lkrehi 2704 20 the the DT cord-335975-m6lkrehi 2704 21 simulated simulated JJ cord-335975-m6lkrehi 2704 22 respiratory respiratory JJ cord-335975-m6lkrehi 2704 23 effort effort NN cord-335975-m6lkrehi 2704 24 ( ( -LRB- cord-335975-m6lkrehi 2704 25 599 599 CD cord-335975-m6lkrehi 2704 26 ± ± CD cord-335975-m6lkrehi 2704 27 201 201 CD cord-335975-m6lkrehi 2704 28 and and CC cord-335975-m6lkrehi 2704 29 537 537 CD cord-335975-m6lkrehi 2704 30 ± ± CD cord-335975-m6lkrehi 2704 31 217 217 CD cord-335975-m6lkrehi 2704 32 vs. vs. IN cord-335975-m6lkrehi 2704 33 307 307 CD cord-335975-m6lkrehi 2704 34 ± ± CD cord-335975-m6lkrehi 2704 35 121 121 CD cord-335975-m6lkrehi 2704 36 ml ml NNS cord-335975-m6lkrehi 2704 37 respectively respectively RB cord-335975-m6lkrehi 2704 38 with with IN cord-335975-m6lkrehi 2704 39 the the DT cord-335975-m6lkrehi 2704 40 moderate moderate JJ cord-335975-m6lkrehi 2704 41 simulated simulated JJ cord-335975-m6lkrehi 2704 42 effort effort NN cord-335975-m6lkrehi 2704 43 , , , cord-335975-m6lkrehi 2704 44 p p NN cord-335975-m6lkrehi 2704 45 < < XX cord-335975-m6lkrehi 2704 46 0.001 0.001 CD cord-335975-m6lkrehi 2704 47 ; ; : cord-335975-m6lkrehi 2704 48 Fig Fig NNP cord-335975-m6lkrehi 2704 49 . . NNP cord-335975-m6lkrehi 2704 50 1 1 CD cord-335975-m6lkrehi 2704 51 ) ) -RRB- cord-335975-m6lkrehi 2704 52 . . . cord-335975-m6lkrehi 2705 1 HFNC HFNC NNP cord-335975-m6lkrehi 2705 2 and and CC cord-335975-m6lkrehi 2705 3 CPAP CPAP NNP cord-335975-m6lkrehi 2705 4 were be VBD cord-335975-m6lkrehi 2705 5 associated associate VBN cord-335975-m6lkrehi 2705 6 with with IN cord-335975-m6lkrehi 2705 7 a a DT cord-335975-m6lkrehi 2705 8 slight slight JJ cord-335975-m6lkrehi 2705 9 but but CC cord-335975-m6lkrehi 2705 10 non non JJ cord-335975-m6lkrehi 2705 11 - - JJ cord-335975-m6lkrehi 2705 12 significant significant JJ cord-335975-m6lkrehi 2705 13 decrease decrease NN cord-335975-m6lkrehi 2705 14 in in IN cord-335975-m6lkrehi 2705 15 Vt Vt NNP cord-335975-m6lkrehi 2705 16 as as IN cord-335975-m6lkrehi 2705 17 compared compare VBN cord-335975-m6lkrehi 2705 18 to to IN cord-335975-m6lkrehi 2705 19 the the DT cord-335975-m6lkrehi 2705 20 oxygen oxygen NN cord-335975-m6lkrehi 2705 21 mask mask NN cord-335975-m6lkrehi 2705 22 . . . cord-335975-m6lkrehi 2706 1 Overall overall RB cord-335975-m6lkrehi 2706 2 , , , cord-335975-m6lkrehi 2706 3 for for IN cord-335975-m6lkrehi 2706 4 a a DT cord-335975-m6lkrehi 2706 5 given give VBN cord-335975-m6lkrehi 2706 6 respiratory respiratory JJ cord-335975-m6lkrehi 2706 7 effort effort NN cord-335975-m6lkrehi 2706 8 , , , cord-335975-m6lkrehi 2706 9 Vt Vt NNP cord-335975-m6lkrehi 2706 10 was be VBD cord-335975-m6lkrehi 2706 11 influenced influence VBN cord-335975-m6lkrehi 2706 12 by by IN cord-335975-m6lkrehi 2706 13 the the DT cord-335975-m6lkrehi 2706 14 " " `` cord-335975-m6lkrehi 2706 15 device device NN cord-335975-m6lkrehi 2706 16 driving drive VBG cord-335975-m6lkrehi 2706 17 pressure pressure NN cord-335975-m6lkrehi 2706 18 " " '' cord-335975-m6lkrehi 2706 19 , , , cord-335975-m6lkrehi 2706 20 which which WDT cord-335975-m6lkrehi 2706 21 tended tend VBD cord-335975-m6lkrehi 2706 22 to to TO cord-335975-m6lkrehi 2706 23 decrease decrease VB cord-335975-m6lkrehi 2706 24 when when WRB cord-335975-m6lkrehi 2706 25 using use VBG cord-335975-m6lkrehi 2706 26 HFNC HFNC NNP cord-335975-m6lkrehi 2706 27 and and CC cord-335975-m6lkrehi 2706 28 CPAP CPAP NNP cord-335975-m6lkrehi 2706 29 and and CC cord-335975-m6lkrehi 2706 30 markedly markedly RB cord-335975-m6lkrehi 2706 31 increased increase VBD cord-335975-m6lkrehi 2706 32 with with IN cord-335975-m6lkrehi 2706 33 M M NNP cord-335975-m6lkrehi 2706 34 - - HYPH cord-335975-m6lkrehi 2706 35 NIV NIV NNP cord-335975-m6lkrehi 2706 36 as as IN cord-335975-m6lkrehi 2706 37 compared compare VBN cord-335975-m6lkrehi 2706 38 to to IN cord-335975-m6lkrehi 2706 39 the the DT cord-335975-m6lkrehi 2706 40 oxygen oxygen NN cord-335975-m6lkrehi 2706 41 mask mask NN cord-335975-m6lkrehi 2706 42 . . . cord-335975-m6lkrehi 2707 1 Therefore therefore RB cord-335975-m6lkrehi 2707 2 , , , cord-335975-m6lkrehi 2707 3 Vt Vt NNP cord-335975-m6lkrehi 2707 4 in in IN cord-335975-m6lkrehi 2707 5 M M NNP cord-335975-m6lkrehi 2707 6 - - HYPH cord-335975-m6lkrehi 2707 7 NIV NIV NNP cord-335975-m6lkrehi 2707 8 with with IN cord-335975-m6lkrehi 2707 9 a a DT cord-335975-m6lkrehi 2707 10 simulated simulated JJ cord-335975-m6lkrehi 2707 11 low low JJ cord-335975-m6lkrehi 2707 12 effort effort NN cord-335975-m6lkrehi 2707 13 was be VBD cord-335975-m6lkrehi 2707 14 significantly significantly RB cord-335975-m6lkrehi 2707 15 higher high JJR cord-335975-m6lkrehi 2707 16 than than IN cord-335975-m6lkrehi 2707 17 Vt Vt NNP cord-335975-m6lkrehi 2707 18 in in IN cord-335975-m6lkrehi 2707 19 CPAP CPAP NNP cord-335975-m6lkrehi 2707 20 and and CC cord-335975-m6lkrehi 2707 21 HFNC HFNC NNP cord-335975-m6lkrehi 2707 22 with with IN cord-335975-m6lkrehi 2707 23 a a DT cord-335975-m6lkrehi 2707 24 simulated simulated JJ cord-335975-m6lkrehi 2707 25 moderate moderate JJ cord-335975-m6lkrehi 2707 26 effort effort NN cord-335975-m6lkrehi 2707 27 ( ( -LRB- cord-335975-m6lkrehi 2707 28 456 456 CD cord-335975-m6lkrehi 2707 29 ± ± CD cord-335975-m6lkrehi 2707 30 162 162 CD cord-335975-m6lkrehi 2707 31 ml ml NNS cord-335975-m6lkrehi 2707 32 , , , cord-335975-m6lkrehi 2707 33 252 252 CD cord-335975-m6lkrehi 2707 34 ± ± NNP cord-335975-m6lkrehi 2707 35 95 95 CD cord-335975-m6lkrehi 2707 36 ml ml NNS cord-335975-m6lkrehi 2707 37 , , , cord-335975-m6lkrehi 2707 38 and and CC cord-335975-m6lkrehi 2707 39 262 262 CD cord-335975-m6lkrehi 2707 40 ± ± CD cord-335975-m6lkrehi 2707 41 90 90 CD cord-335975-m6lkrehi 2707 42 ml ml NN cord-335975-m6lkrehi 2707 43 respectively respectively RB cord-335975-m6lkrehi 2707 44 , , , cord-335975-m6lkrehi 2707 45 p p NN cord-335975-m6lkrehi 2707 46 = = SYM cord-335975-m6lkrehi 2707 47 0.01 0.01 CD cord-335975-m6lkrehi 2707 48 for for IN cord-335975-m6lkrehi 2707 49 both both DT cord-335975-m6lkrehi 2707 50 comparisons comparison NNS cord-335975-m6lkrehi 2707 51 ) ) -RRB- cord-335975-m6lkrehi 2707 52 . . . cord-335975-m6lkrehi 2708 1 Conclusion conclusion NN cord-335975-m6lkrehi 2708 2 : : : cord-335975-m6lkrehi 2709 1 In in IN cord-335975-m6lkrehi 2709 2 our -PRON- PRP$ cord-335975-m6lkrehi 2709 3 bench bench NN cord-335975-m6lkrehi 2709 4 model model NN cord-335975-m6lkrehi 2709 5 , , , cord-335975-m6lkrehi 2709 6 the the DT cord-335975-m6lkrehi 2709 7 Vt Vt NNP cord-335975-m6lkrehi 2709 8 value value NN cord-335975-m6lkrehi 2709 9 was be VBD cord-335975-m6lkrehi 2709 10 significantly significantly RB cord-335975-m6lkrehi 2709 11 influenced influence VBN cord-335975-m6lkrehi 2709 12 by by IN cord-335975-m6lkrehi 2709 13 the the DT cord-335975-m6lkrehi 2709 14 noninvasive noninvasive JJ cord-335975-m6lkrehi 2709 15 ventilatory ventilatory JJ cord-335975-m6lkrehi 2709 16 device device NN cord-335975-m6lkrehi 2709 17 . . . cord-335975-m6lkrehi 2710 1 NIV NIV NNP cord-335975-m6lkrehi 2710 2 was be VBD cord-335975-m6lkrehi 2710 3 invariably invariably RB cord-335975-m6lkrehi 2710 4 associated associate VBN cord-335975-m6lkrehi 2710 5 with with IN cord-335975-m6lkrehi 2710 6 significantly significantly RB cord-335975-m6lkrehi 2710 7 higher high JJR cord-335975-m6lkrehi 2710 8 Vt Vt NNP cord-335975-m6lkrehi 2710 9 than than IN cord-335975-m6lkrehi 2710 10 with with IN cord-335975-m6lkrehi 2710 11 other other JJ cord-335975-m6lkrehi 2710 12 devices device NNS cord-335975-m6lkrehi 2710 13 , , , cord-335975-m6lkrehi 2710 14 even even RB cord-335975-m6lkrehi 2710 15 when when WRB cord-335975-m6lkrehi 2710 16 dividing divide VBG cord-335975-m6lkrehi 2710 17 by by IN cord-335975-m6lkrehi 2710 18 two two CD cord-335975-m6lkrehi 2710 19 the the DT cord-335975-m6lkrehi 2710 20 simulated simulated JJ cord-335975-m6lkrehi 2710 21 inspiratory inspiratory JJ cord-335975-m6lkrehi 2710 22 effort effort NN cord-335975-m6lkrehi 2710 23 during during IN cord-335975-m6lkrehi 2710 24 NIV NIV NNP cord-335975-m6lkrehi 2710 25 . . . cord-335975-m6lkrehi 2710 26 _SP cord-335975-m6lkrehi 2711 1 Introduction introduction NN cord-335975-m6lkrehi 2711 2 : : : cord-335975-m6lkrehi 2712 1 In in IN cord-335975-m6lkrehi 2712 2 ICU ICU NNP cord-335975-m6lkrehi 2712 3 , , , cord-335975-m6lkrehi 2712 4 intubation intubation NN cord-335975-m6lkrehi 2712 5 is be VBZ cord-335975-m6lkrehi 2712 6 a a DT cord-335975-m6lkrehi 2712 7 high high JJ cord-335975-m6lkrehi 2712 8 risk risk NN cord-335975-m6lkrehi 2712 9 procedure procedure NN cord-335975-m6lkrehi 2712 10 associated associate VBN cord-335975-m6lkrehi 2712 11 with with IN cord-335975-m6lkrehi 2712 12 high high JJ cord-335975-m6lkrehi 2712 13 morbidity morbidity NN cord-335975-m6lkrehi 2712 14 . . . cord-335975-m6lkrehi 2713 1 Despite despite IN cord-335975-m6lkrehi 2713 2 procedure procedure NN cord-335975-m6lkrehi 2713 3 's 's POS cord-335975-m6lkrehi 2713 4 improvement improvement NN cord-335975-m6lkrehi 2713 5 with with IN cord-335975-m6lkrehi 2713 6 systematic systematic JJ cord-335975-m6lkrehi 2713 7 application application NN cord-335975-m6lkrehi 2713 8 of of IN cord-335975-m6lkrehi 2713 9 fluid fluid JJ cord-335975-m6lkrehi 2713 10 loading loading NN cord-335975-m6lkrehi 2713 11 , , , cord-335975-m6lkrehi 2713 12 early early JJ cord-335975-m6lkrehi 2713 13 use use NN cord-335975-m6lkrehi 2713 14 of of IN cord-335975-m6lkrehi 2713 15 vasopressors vasopressor NNS cord-335975-m6lkrehi 2713 16 and and CC cord-335975-m6lkrehi 2713 17 checklist checklist NN cord-335975-m6lkrehi 2713 18 use use NN cord-335975-m6lkrehi 2713 19 , , , cord-335975-m6lkrehi 2713 20 morbidity morbidity NN cord-335975-m6lkrehi 2713 21 remains remain VBZ cord-335975-m6lkrehi 2713 22 high high JJ cord-335975-m6lkrehi 2713 23 . . . cord-335975-m6lkrehi 2714 1 Several several JJ cord-335975-m6lkrehi 2714 2 recent recent JJ cord-335975-m6lkrehi 2714 3 trials trial NNS cord-335975-m6lkrehi 2714 4 has have VBZ cord-335975-m6lkrehi 2714 5 been be VBN cord-335975-m6lkrehi 2714 6 conducted conduct VBN cord-335975-m6lkrehi 2714 7 with with IN cord-335975-m6lkrehi 2714 8 different different JJ cord-335975-m6lkrehi 2714 9 metrics metric NNS cord-335975-m6lkrehi 2714 10 choose choose VBP cord-335975-m6lkrehi 2714 11 as as IN cord-335975-m6lkrehi 2714 12 primary primary JJ cord-335975-m6lkrehi 2714 13 outcome outcome NN cord-335975-m6lkrehi 2714 14 . . . cord-335975-m6lkrehi 2715 1 However however RB cord-335975-m6lkrehi 2715 2 any any DT cord-335975-m6lkrehi 2715 3 evidence evidence NN cord-335975-m6lkrehi 2715 4 exists exist VBZ cord-335975-m6lkrehi 2715 5 to to TO cord-335975-m6lkrehi 2715 6 choose choose VB cord-335975-m6lkrehi 2715 7 one one CD cord-335975-m6lkrehi 2715 8 more more JJR cord-335975-m6lkrehi 2715 9 than than IN cord-335975-m6lkrehi 2715 10 another another DT cord-335975-m6lkrehi 2715 11 : : : cord-335975-m6lkrehi 2715 12 time time NN cord-335975-m6lkrehi 2715 13 to to IN cord-335975-m6lkrehi 2715 14 intubation intubation NN cord-335975-m6lkrehi 2715 15 , , , cord-335975-m6lkrehi 2715 16 first first JJ cord-335975-m6lkrehi 2715 17 pass pass NN cord-335975-m6lkrehi 2715 18 success success NN cord-335975-m6lkrehi 2715 19 , , , cord-335975-m6lkrehi 2715 20 difficult difficult JJ cord-335975-m6lkrehi 2715 21 intubation intubation NN cord-335975-m6lkrehi 2715 22 . . . cord-335975-m6lkrehi 2716 1 First first JJ cord-335975-m6lkrehi 2716 2 pass pass NN cord-335975-m6lkrehi 2716 3 success success NN cord-335975-m6lkrehi 2716 4 sine sine NN cord-335975-m6lkrehi 2716 5 hypoxia hypoxia NN cord-335975-m6lkrehi 2716 6 and and CC cord-335975-m6lkrehi 2716 7 hypotension hypotension NN cord-335975-m6lkrehi 2716 8 ( ( -LRB- cord-335975-m6lkrehi 2716 9 DASH-1A DASH-1A NNP cord-335975-m6lkrehi 2716 10 ) ) -RRB- cord-335975-m6lkrehi 2716 11 has have VBZ cord-335975-m6lkrehi 2716 12 been be VBN cord-335975-m6lkrehi 2716 13 highlighted highlight VBN cord-335975-m6lkrehi 2716 14 recently recently RB cord-335975-m6lkrehi 2716 15 and and CC cord-335975-m6lkrehi 2716 16 choose choose VB cord-335975-m6lkrehi 2716 17 by by IN cord-335975-m6lkrehi 2716 18 the the DT cord-335975-m6lkrehi 2716 19 GAME GAME NNP cord-335975-m6lkrehi 2716 20 program program NN cord-335975-m6lkrehi 2716 21 without without IN cord-335975-m6lkrehi 2716 22 any any DT cord-335975-m6lkrehi 2716 23 scientific scientific JJ cord-335975-m6lkrehi 2716 24 evaluation evaluation NN cord-335975-m6lkrehi 2716 25 . . . cord-335975-m6lkrehi 2717 1 We -PRON- PRP cord-335975-m6lkrehi 2717 2 conducted conduct VBD cord-335975-m6lkrehi 2717 3 a a DT cord-335975-m6lkrehi 2717 4 post post FW cord-335975-m6lkrehi 2717 5 hoc hoc FW cord-335975-m6lkrehi 2717 6 analysis analysis NN cord-335975-m6lkrehi 2717 7 of of IN cord-335975-m6lkrehi 2717 8 the the DT cord-335975-m6lkrehi 2717 9 randomized randomized JJ cord-335975-m6lkrehi 2717 10 clinical clinical JJ cord-335975-m6lkrehi 2717 11 trial trial NN cord-335975-m6lkrehi 2717 12 MacGrath MacGrath NNP cord-335975-m6lkrehi 2717 13 Mac Mac NNP cord-335975-m6lkrehi 2717 14 video video NN cord-335975-m6lkrehi 2717 15 laryngoscope laryngoscope NN cord-335975-m6lkrehi 2717 16 or or CC cord-335975-m6lkrehi 2717 17 Macintosh Macintosh NNP cord-335975-m6lkrehi 2717 18 laryngoscope laryngoscope NN cord-335975-m6lkrehi 2717 19 for for IN cord-335975-m6lkrehi 2717 20 intubation intubation NN cord-335975-m6lkrehi 2717 21 in in IN cord-335975-m6lkrehi 2717 22 the the DT cord-335975-m6lkrehi 2717 23 intensive intensive JJ cord-335975-m6lkrehi 2717 24 care care NN cord-335975-m6lkrehi 2717 25 unit unit NN cord-335975-m6lkrehi 2717 26 ( ( -LRB- cord-335975-m6lkrehi 2717 27 MACMAN MACMAN NNP cord-335975-m6lkrehi 2717 28 ) ) -RRB- cord-335975-m6lkrehi 2717 29 to to TO cord-335975-m6lkrehi 2717 30 determine determine VB cord-335975-m6lkrehi 2717 31 the the DT cord-335975-m6lkrehi 2717 32 best good JJS cord-335975-m6lkrehi 2717 33 metric metric NN cord-335975-m6lkrehi 2717 34 to to TO cord-335975-m6lkrehi 2717 35 choose choose VB cord-335975-m6lkrehi 2717 36 for for IN cord-335975-m6lkrehi 2717 37 primary primary JJ cord-335975-m6lkrehi 2717 38 outcome outcome NN cord-335975-m6lkrehi 2717 39 for for IN cord-335975-m6lkrehi 2717 40 the the DT cord-335975-m6lkrehi 2717 41 next next JJ cord-335975-m6lkrehi 2717 42 intubation intubation NN cord-335975-m6lkrehi 2717 43 studies study NNS cord-335975-m6lkrehi 2717 44 in in IN cord-335975-m6lkrehi 2717 45 ICU ICU NNP cord-335975-m6lkrehi 2717 46 . . . cord-335975-m6lkrehi 2718 1 Patients patient NNS cord-335975-m6lkrehi 2718 2 and and CC cord-335975-m6lkrehi 2718 3 methods method NNS cord-335975-m6lkrehi 2718 4 : : : cord-335975-m6lkrehi 2718 5 MACMAN MACMAN NNP cord-335975-m6lkrehi 2718 6 was be VBD cord-335975-m6lkrehi 2718 7 a a DT cord-335975-m6lkrehi 2718 8 multicentre multicentre NN cord-335975-m6lkrehi 2718 9 , , , cord-335975-m6lkrehi 2718 10 open open JJ cord-335975-m6lkrehi 2718 11 - - HYPH cord-335975-m6lkrehi 2718 12 label label NN cord-335975-m6lkrehi 2718 13 , , , cord-335975-m6lkrehi 2718 14 randomized randomized JJ cord-335975-m6lkrehi 2718 15 controlled controlled JJ cord-335975-m6lkrehi 2718 16 superiority superiority NN cord-335975-m6lkrehi 2718 17 trial trial NN cord-335975-m6lkrehi 2718 18 . . . cord-335975-m6lkrehi 2719 1 Consecutive consecutive JJ cord-335975-m6lkrehi 2719 2 patients patient NNS cord-335975-m6lkrehi 2719 3 requiring require VBG cord-335975-m6lkrehi 2719 4 intubation intubation NN cord-335975-m6lkrehi 2719 5 were be VBD cord-335975-m6lkrehi 2719 6 randomly randomly RB cord-335975-m6lkrehi 2719 7 allocated allocate VBN cord-335975-m6lkrehi 2719 8 to to IN cord-335975-m6lkrehi 2719 9 either either CC cord-335975-m6lkrehi 2719 10 the the DT cord-335975-m6lkrehi 2719 11 McGRATH McGRATH NNP cord-335975-m6lkrehi 2719 12 MAC MAC NNP cord-335975-m6lkrehi 2719 13 videolaryngoscope videolaryngoscope NN cord-335975-m6lkrehi 2719 14 or or CC cord-335975-m6lkrehi 2719 15 the the DT cord-335975-m6lkrehi 2719 16 Macintosh Macintosh NNP cord-335975-m6lkrehi 2719 17 laryngoscope laryngoscope NN cord-335975-m6lkrehi 2719 18 , , , cord-335975-m6lkrehi 2719 19 with with IN cord-335975-m6lkrehi 2719 20 stratification stratification NN cord-335975-m6lkrehi 2719 21 by by IN cord-335975-m6lkrehi 2719 22 centre centre NN cord-335975-m6lkrehi 2719 23 and and CC cord-335975-m6lkrehi 2719 24 operator operator NN cord-335975-m6lkrehi 2719 25 experience experience NN cord-335975-m6lkrehi 2719 26 . . . cord-335975-m6lkrehi 2720 1 An an DT cord-335975-m6lkrehi 2720 2 only only JJ cord-335975-m6lkrehi 2720 3 inclusion inclusion NN cord-335975-m6lkrehi 2720 4 criterion criterion NN cord-335975-m6lkrehi 2720 5 was-"Patients was-"Patients NNP cord-335975-m6lkrehi 2720 6 must must MD cord-335975-m6lkrehi 2720 7 be be VB cord-335975-m6lkrehi 2720 8 admitted admit VBN cord-335975-m6lkrehi 2720 9 to to IN cord-335975-m6lkrehi 2720 10 an an DT cord-335975-m6lkrehi 2720 11 ICU ICU NNP cord-335975-m6lkrehi 2720 12 and and CC cord-335975-m6lkrehi 2720 13 require require VB cord-335975-m6lkrehi 2720 14 mechanical mechanical JJ cord-335975-m6lkrehi 2720 15 ventilation ventilation NN cord-335975-m6lkrehi 2720 16 through through IN cord-335975-m6lkrehi 2720 17 an an DT cord-335975-m6lkrehi 2720 18 endotracheal endotracheal NN cord-335975-m6lkrehi 2720 19 tube tube NN cord-335975-m6lkrehi 2720 20 " " '' cord-335975-m6lkrehi 2720 21 . . . cord-335975-m6lkrehi 2721 1 Patients patient NNS cord-335975-m6lkrehi 2721 2 were be VBD cord-335975-m6lkrehi 2721 3 excluded exclude VBN cord-335975-m6lkrehi 2721 4 if if IN cord-335975-m6lkrehi 2721 5 - - HYPH cord-335975-m6lkrehi 2721 6 contraindication contraindication NN cord-335975-m6lkrehi 2721 7 to to IN cord-335975-m6lkrehi 2721 8 orotracheal orotracheal JJ cord-335975-m6lkrehi 2721 9 intubation intubation NN cord-335975-m6lkrehi 2721 10 ( ( -LRB- cord-335975-m6lkrehi 2721 11 e.g. e.g. RB cord-335975-m6lkrehi 2721 12 , , , cord-335975-m6lkrehi 2721 13 unstable unstable JJ cord-335975-m6lkrehi 2721 14 spinal spinal JJ cord-335975-m6lkrehi 2721 15 lesion lesion NN cord-335975-m6lkrehi 2721 16 ) ) -RRB- cord-335975-m6lkrehi 2721 17 + + CC cord-335975-m6lkrehi 2721 18 insufficient insufficient JJ cord-335975-m6lkrehi 2721 19 time time NN cord-335975-m6lkrehi 2721 20 to to TO cord-335975-m6lkrehi 2721 21 include include VB cord-335975-m6lkrehi 2721 22 and and CC cord-335975-m6lkrehi 2721 23 randomize randomize VB cord-335975-m6lkrehi 2721 24 the the DT cord-335975-m6lkrehi 2721 25 patient patient NN cord-335975-m6lkrehi 2721 26 ( ( -LRB- cord-335975-m6lkrehi 2721 27 e.g. e.g. RB cord-335975-m6lkrehi 2721 28 , , , cord-335975-m6lkrehi 2721 29 because because IN cord-335975-m6lkrehi 2721 30 of of IN cord-335975-m6lkrehi 2721 31 cardiac cardiac JJ cord-335975-m6lkrehi 2721 32 arrest arrest NN cord-335975-m6lkrehi 2721 33 ) ) -RRB- cord-335975-m6lkrehi 2721 34 + + CC cord-335975-m6lkrehi 2721 35 age age NN cord-335975-m6lkrehi 2721 36 < < XX cord-335975-m6lkrehi 2721 37 18 18 CD cord-335975-m6lkrehi 2721 38 years year NNS cord-335975-m6lkrehi 2721 39 + + CC cord-335975-m6lkrehi 2721 40 pregnant pregnant JJ cord-335975-m6lkrehi 2721 41 or or CC cord-335975-m6lkrehi 2721 42 breastfeeding breastfeed VBG cord-335975-m6lkrehi 2721 43 woman woman NN cord-335975-m6lkrehi 2721 44 + + CC cord-335975-m6lkrehi 2721 45 correctional correctional NNP cord-335975-m6lkrehi 2721 46 facility facility NN cord-335975-m6lkrehi 2721 47 inmate inmate NN cord-335975-m6lkrehi 2721 48 + + CC cord-335975-m6lkrehi 2721 49 patient patient NN cord-335975-m6lkrehi 2721 50 under under IN cord-335975-m6lkrehi 2721 51 guardianship guardianship NN cord-335975-m6lkrehi 2721 52 + + CC cord-335975-m6lkrehi 2721 53 patient patient NN cord-335975-m6lkrehi 2721 54 without without IN cord-335975-m6lkrehi 2721 55 health health NN cord-335975-m6lkrehi 2721 56 insurance insurance NN cord-335975-m6lkrehi 2721 57 + + CC cord-335975-m6lkrehi 2721 58 refusal refusal NN cord-335975-m6lkrehi 2721 59 of of IN cord-335975-m6lkrehi 2721 60 the the DT cord-335975-m6lkrehi 2721 61 patient patient NN cord-335975-m6lkrehi 2721 62 or or CC cord-335975-m6lkrehi 2721 63 next next JJ cord-335975-m6lkrehi 2721 64 of of IN cord-335975-m6lkrehi 2721 65 kin kin NN cord-335975-m6lkrehi 2721 66 to to TO cord-335975-m6lkrehi 2721 67 participate participate VB cord-335975-m6lkrehi 2721 68 in in IN cord-335975-m6lkrehi 2721 69 the the DT cord-335975-m6lkrehi 2721 70 study study NN cord-335975-m6lkrehi 2721 71 + + CC cord-335975-m6lkrehi 2721 72 previous previous JJ cord-335975-m6lkrehi 2721 73 enrolment enrolment NN cord-335975-m6lkrehi 2721 74 in in IN cord-335975-m6lkrehi 2721 75 a a DT cord-335975-m6lkrehi 2721 76 clinical clinical JJ cord-335975-m6lkrehi 2721 77 randomized randomized JJ cord-335975-m6lkrehi 2721 78 trial trial NN cord-335975-m6lkrehi 2721 79 with with IN cord-335975-m6lkrehi 2721 80 intubation intubation NN cord-335975-m6lkrehi 2721 81 as as IN cord-335975-m6lkrehi 2721 82 the the DT cord-335975-m6lkrehi 2721 83 primary primary JJ cord-335975-m6lkrehi 2721 84 end end NN cord-335975-m6lkrehi 2721 85 point point NN cord-335975-m6lkrehi 2721 86 ( ( -LRB- cord-335975-m6lkrehi 2721 87 including include VBG cord-335975-m6lkrehi 2721 88 previous previous JJ cord-335975-m6lkrehi 2721 89 inclusion inclusion NN cord-335975-m6lkrehi 2721 90 in in IN cord-335975-m6lkrehi 2721 91 the the DT cord-335975-m6lkrehi 2721 92 present present JJ cord-335975-m6lkrehi 2721 93 trial trial NN cord-335975-m6lkrehi 2721 94 ) ) -RRB- cord-335975-m6lkrehi 2721 95 . . . cord-335975-m6lkrehi 2722 1 Post post JJ cord-335975-m6lkrehi 2722 2 - - JJ cord-335975-m6lkrehi 2722 3 hoc hoc JJ cord-335975-m6lkrehi 2722 4 analysis analysis NN cord-335975-m6lkrehi 2722 5 was be VBD cord-335975-m6lkrehi 2722 6 performed perform VBN cord-335975-m6lkrehi 2722 7 to to TO cord-335975-m6lkrehi 2722 8 assess assess VB cord-335975-m6lkrehi 2722 9 association association NN cord-335975-m6lkrehi 2722 10 and and CC cord-335975-m6lkrehi 2722 11 prediction prediction NN cord-335975-m6lkrehi 2722 12 of of IN cord-335975-m6lkrehi 2722 13 life life NN cord-335975-m6lkrehi 2722 14 threatening threaten VBG cord-335975-m6lkrehi 2722 15 complication complication NN cord-335975-m6lkrehi 2722 16 ( ( -LRB- cord-335975-m6lkrehi 2722 17 mild mild JJ cord-335975-m6lkrehi 2722 18 to to TO cord-335975-m6lkrehi 2722 19 moderate moderate JJ cord-335975-m6lkrehi 2722 20 , , , cord-335975-m6lkrehi 2722 21 severe severe JJ cord-335975-m6lkrehi 2722 22 , , , cord-335975-m6lkrehi 2722 23 mild mild JJ cord-335975-m6lkrehi 2722 24 to to IN cord-335975-m6lkrehi 2722 25 severe severe JJ cord-335975-m6lkrehi 2722 26 ) ) -RRB- cord-335975-m6lkrehi 2722 27 by by IN cord-335975-m6lkrehi 2722 28 different different JJ cord-335975-m6lkrehi 2722 29 metric metric JJ cord-335975-m6lkrehi 2722 30 existing exist VBG cord-335975-m6lkrehi 2722 31 - - HYPH cord-335975-m6lkrehi 2722 32 time time NN cord-335975-m6lkrehi 2722 33 to to IN cord-335975-m6lkrehi 2722 34 intubation intubation NN cord-335975-m6lkrehi 2722 35 , , , cord-335975-m6lkrehi 2722 36 first first JJ cord-335975-m6lkrehi 2722 37 pass pass NN cord-335975-m6lkrehi 2722 38 success success NN cord-335975-m6lkrehi 2722 39 , , , cord-335975-m6lkrehi 2722 40 difficult difficult JJ cord-335975-m6lkrehi 2722 41 intubation intubation NN cord-335975-m6lkrehi 2722 42 , , , cord-335975-m6lkrehi 2722 43 first first JJ cord-335975-m6lkrehi 2722 44 pass pass NN cord-335975-m6lkrehi 2722 45 success success NN cord-335975-m6lkrehi 2722 46 sine sine NN cord-335975-m6lkrehi 2722 47 hypoxia hypoxia NN cord-335975-m6lkrehi 2722 48 and and CC cord-335975-m6lkrehi 2722 49 hypotension hypotension NN cord-335975-m6lkrehi 2722 50 . . . cord-335975-m6lkrehi 2723 1 Each each DT cord-335975-m6lkrehi 2723 2 metric metric NN cord-335975-m6lkrehi 2723 3 was be VBD cord-335975-m6lkrehi 2723 4 compared compare VBN cord-335975-m6lkrehi 2723 5 with with IN cord-335975-m6lkrehi 2723 6 another another DT cord-335975-m6lkrehi 2723 7 one one NN cord-335975-m6lkrehi 2723 8 . . . cord-335975-m6lkrehi 2724 1 Area area NN cord-335975-m6lkrehi 2724 2 under under IN cord-335975-m6lkrehi 2724 3 curve curve NN cord-335975-m6lkrehi 2724 4 was be VBD cord-335975-m6lkrehi 2724 5 built build VBN cord-335975-m6lkrehi 2724 6 for for IN cord-335975-m6lkrehi 2724 7 every every DT cord-335975-m6lkrehi 2724 8 metric metric NN cord-335975-m6lkrehi 2724 9 and and CC cord-335975-m6lkrehi 2724 10 all all DT cord-335975-m6lkrehi 2724 11 metrics metric NNS cord-335975-m6lkrehi 2724 12 were be VBD cord-335975-m6lkrehi 2724 13 then then RB cord-335975-m6lkrehi 2724 14 compared compare VBN cord-335975-m6lkrehi 2724 15 . . . cord-335975-m6lkrehi 2725 1 Results result NNS cord-335975-m6lkrehi 2725 2 : : : cord-335975-m6lkrehi 2726 1 DASH-1A DASH-1A NNP cord-335975-m6lkrehi 2726 2 was be VBD cord-335975-m6lkrehi 2726 3 superior superior JJ cord-335975-m6lkrehi 2726 4 to to IN cord-335975-m6lkrehi 2726 5 all all DT cord-335975-m6lkrehi 2726 6 others other NNS cord-335975-m6lkrehi 2726 7 metrics metric NNS cord-335975-m6lkrehi 2726 8 included include VBN cord-335975-m6lkrehi 2726 9 in in IN cord-335975-m6lkrehi 2726 10 the the DT cord-335975-m6lkrehi 2726 11 analysis analysis NN cord-335975-m6lkrehi 2726 12 for for IN cord-335975-m6lkrehi 2726 13 prediction prediction NN cord-335975-m6lkrehi 2726 14 of of IN cord-335975-m6lkrehi 2726 15 life life NN cord-335975-m6lkrehi 2726 16 threatning threatne VBG cord-335975-m6lkrehi 2726 17 complications complication NNS cord-335975-m6lkrehi 2726 18 ( ( -LRB- cord-335975-m6lkrehi 2726 19 all all DT cord-335975-m6lkrehi 2726 20 p p NN cord-335975-m6lkrehi 2726 21 < < XX cord-335975-m6lkrehi 2726 22 0.001 0.001 CD cord-335975-m6lkrehi 2726 23 ) ) -RRB- cord-335975-m6lkrehi 2726 24 . . . cord-335975-m6lkrehi 2727 1 Failure failure NN cord-335975-m6lkrehi 2727 2 of of IN cord-335975-m6lkrehi 2727 3 first first JJ cord-335975-m6lkrehi 2727 4 pass pass NN cord-335975-m6lkrehi 2727 5 Conclusion conclusion NN cord-335975-m6lkrehi 2727 6 : : : cord-335975-m6lkrehi 2727 7 All all DT cord-335975-m6lkrehi 2727 8 metrics metric NNS cord-335975-m6lkrehi 2727 9 are be VBP cord-335975-m6lkrehi 2727 10 not not RB cord-335975-m6lkrehi 2727 11 equal equal JJ cord-335975-m6lkrehi 2727 12 to to TO cord-335975-m6lkrehi 2727 13 predict predict VB cord-335975-m6lkrehi 2727 14 severe severe JJ cord-335975-m6lkrehi 2727 15 life life NN cord-335975-m6lkrehi 2727 16 threatening threaten VBG cord-335975-m6lkrehi 2727 17 complications complication NNS cord-335975-m6lkrehi 2727 18 during during IN cord-335975-m6lkrehi 2727 19 intubation intubation NN cord-335975-m6lkrehi 2727 20 in in IN cord-335975-m6lkrehi 2727 21 the the DT cord-335975-m6lkrehi 2727 22 ICU ICU NNP cord-335975-m6lkrehi 2727 23 . . . cord-335975-m6lkrehi 2728 1 In in IN cord-335975-m6lkrehi 2728 2 this this DT cord-335975-m6lkrehi 2728 3 context context NN cord-335975-m6lkrehi 2728 4 , , , cord-335975-m6lkrehi 2728 5 we -PRON- PRP cord-335975-m6lkrehi 2728 6 recommend recommend VBP cord-335975-m6lkrehi 2728 7 adoption adoption NN cord-335975-m6lkrehi 2728 8 of of IN cord-335975-m6lkrehi 2728 9 definitive definitive JJ cord-335975-m6lkrehi 2728 10 airway airway NN cord-335975-m6lkrehi 2728 11 sine sine NN cord-335975-m6lkrehi 2728 12 hypoxia hypoxia NN cord-335975-m6lkrehi 2728 13 or or CC cord-335975-m6lkrehi 2728 14 hypotension hypotension NN cord-335975-m6lkrehi 2728 15 at at IN cord-335975-m6lkrehi 2728 16 first first JJ cord-335975-m6lkrehi 2728 17 attempt attempt NN cord-335975-m6lkrehi 2728 18 ( ( -LRB- cord-335975-m6lkrehi 2728 19 DASH-1A DASH-1A NNP cord-335975-m6lkrehi 2728 20 ) ) -RRB- cord-335975-m6lkrehi 2728 21 as as IN cord-335975-m6lkrehi 2728 22 primary primary JJ cord-335975-m6lkrehi 2728 23 outcome outcome NN cord-335975-m6lkrehi 2728 24 for for IN cord-335975-m6lkrehi 2728 25 intubation intubation NN cord-335975-m6lkrehi 2728 26 studies study NNS cord-335975-m6lkrehi 2728 27 in in IN cord-335975-m6lkrehi 2728 28 the the DT cord-335975-m6lkrehi 2728 29 ICU ICU NNP cord-335975-m6lkrehi 2728 30 or or CC cord-335975-m6lkrehi 2728 31 as as RB cord-335975-m6lkrehi 2728 32 metric metric JJ cord-335975-m6lkrehi 2728 33 indicator indicator NN cord-335975-m6lkrehi 2728 34 tracked track VBN cord-335975-m6lkrehi 2728 35 in in IN cord-335975-m6lkrehi 2728 36 quality quality NN cord-335975-m6lkrehi 2728 37 improvement improvement NN cord-335975-m6lkrehi 2728 38 program program NN cord-335975-m6lkrehi 2728 39 . . . cord-335975-m6lkrehi 2729 1 Benbernou Benbernou NNP cord-335975-m6lkrehi 2729 2 Soumia Soumia NNP cord-335975-m6lkrehi 2729 3 Introduction introduction NN cord-335975-m6lkrehi 2729 4 : : : cord-335975-m6lkrehi 2729 5 IntroductionAcute IntroductionAcute NNP cord-335975-m6lkrehi 2729 6 respiratory respiratory JJ cord-335975-m6lkrehi 2729 7 failure failure NN cord-335975-m6lkrehi 2729 8 ( ( -LRB- cord-335975-m6lkrehi 2729 9 ARF ARF NNP cord-335975-m6lkrehi 2729 10 ) ) -RRB- cord-335975-m6lkrehi 2729 11 is be VBZ cord-335975-m6lkrehi 2729 12 a a DT cord-335975-m6lkrehi 2729 13 common common JJ cord-335975-m6lkrehi 2729 14 cause cause NN cord-335975-m6lkrehi 2729 15 of of IN cord-335975-m6lkrehi 2729 16 emergency emergency NN cord-335975-m6lkrehi 2729 17 use use NN cord-335975-m6lkrehi 2729 18 and and CC cord-335975-m6lkrehi 2729 19 one one CD cord-335975-m6lkrehi 2729 20 of of IN cord-335975-m6lkrehi 2729 21 the the DT cord-335975-m6lkrehi 2729 22 major major JJ cord-335975-m6lkrehi 2729 23 reasons reason NNS cord-335975-m6lkrehi 2729 24 for for IN cord-335975-m6lkrehi 2729 25 admission admission NN cord-335975-m6lkrehi 2729 26 to to IN cord-335975-m6lkrehi 2729 27 intensive intensive JJ cord-335975-m6lkrehi 2729 28 care care NN cord-335975-m6lkrehi 2729 29 unit unit NN cord-335975-m6lkrehi 2729 30 . . . cord-335975-m6lkrehi 2730 1 It -PRON- PRP cord-335975-m6lkrehi 2730 2 associates associate VBZ cord-335975-m6lkrehi 2730 3 a a DT cord-335975-m6lkrehi 2730 4 vital vital JJ cord-335975-m6lkrehi 2730 5 risk risk NN cord-335975-m6lkrehi 2730 6 imposing impose VBG cord-335975-m6lkrehi 2730 7 immediate immediate JJ cord-335975-m6lkrehi 2730 8 symptomatic symptomatic JJ cord-335975-m6lkrehi 2730 9 treatments treatment NNS cord-335975-m6lkrehi 2730 10 and and CC cord-335975-m6lkrehi 2730 11 an an DT cord-335975-m6lkrehi 2730 12 etiological etiological JJ cord-335975-m6lkrehi 2730 13 approach approach NN cord-335975-m6lkrehi 2730 14 . . . cord-335975-m6lkrehi 2731 1 [ [ -LRB- cord-335975-m6lkrehi 2731 2 1 1 CD cord-335975-m6lkrehi 2731 3 ] ] -RRB- cord-335975-m6lkrehi 2732 1 Among among IN cord-335975-m6lkrehi 2732 2 the the DT cord-335975-m6lkrehi 2732 3 etiologies etiology NNS cord-335975-m6lkrehi 2732 4 of of IN cord-335975-m6lkrehi 2732 5 the the DT cord-335975-m6lkrehi 2732 6 ARF arf NN cord-335975-m6lkrehi 2732 7 , , , cord-335975-m6lkrehi 2732 8 Acute acute JJ cord-335975-m6lkrehi 2732 9 Lung Lung NNP cord-335975-m6lkrehi 2732 10 Edema edema NN cord-335975-m6lkrehi 2732 11 ( ( -LRB- cord-335975-m6lkrehi 2732 12 ALE ALE NNP cord-335975-m6lkrehi 2732 13 ) ) -RRB- cord-335975-m6lkrehi 2732 14 , , , cord-335975-m6lkrehi 2732 15 decompensation decompensation NN cord-335975-m6lkrehi 2732 16 of of IN cord-335975-m6lkrehi 2732 17 chronic chronic JJ cord-335975-m6lkrehi 2732 18 obstructive obstructive JJ cord-335975-m6lkrehi 2732 19 pulmonary pulmonary JJ cord-335975-m6lkrehi 2732 20 disease disease NN cord-335975-m6lkrehi 2732 21 ( ( -LRB- cord-335975-m6lkrehi 2732 22 COPD COPD NNP cord-335975-m6lkrehi 2732 23 ) ) -RRB- cord-335975-m6lkrehi 2732 24 , , , cord-335975-m6lkrehi 2732 25 chest chest NN cord-335975-m6lkrehi 2732 26 trauma trauma NN cord-335975-m6lkrehi 2732 27 and and CC cord-335975-m6lkrehi 2732 28 pneumonia pneumonia NN cord-335975-m6lkrehi 2732 29 are be VBP cord-335975-m6lkrehi 2732 30 the the DT cord-335975-m6lkrehi 2732 31 most most RBS cord-335975-m6lkrehi 2732 32 frequent frequent JJ cord-335975-m6lkrehi 2732 33 @It @It . cord-335975-m6lkrehi 2733 1 is be VBZ cord-335975-m6lkrehi 2733 2 a a DT cord-335975-m6lkrehi 2733 3 life life NN cord-335975-m6lkrehi 2733 4 - - HYPH cord-335975-m6lkrehi 2733 5 threatening threaten VBG cord-335975-m6lkrehi 2733 6 pathology pathology NN cord-335975-m6lkrehi 2733 7 with with IN cord-335975-m6lkrehi 2733 8 a a DT cord-335975-m6lkrehi 2733 9 high high JJ cord-335975-m6lkrehi 2733 10 incidence incidence NN cord-335975-m6lkrehi 2733 11 of of IN cord-335975-m6lkrehi 2733 12 mortality mortality NN cord-335975-m6lkrehi 2733 13 , , , cord-335975-m6lkrehi 2733 14 since since IN cord-335975-m6lkrehi 2733 15 mortality mortality NN cord-335975-m6lkrehi 2733 16 is be VBZ cord-335975-m6lkrehi 2733 17 reported report VBN cord-335975-m6lkrehi 2733 18 to to TO cord-335975-m6lkrehi 2733 19 be be VB cord-335975-m6lkrehi 2733 20 20 20 CD cord-335975-m6lkrehi 2733 21 - - SYM cord-335975-m6lkrehi 2733 22 40 40 CD cord-335975-m6lkrehi 2733 23 % % NN cord-335975-m6lkrehi 2733 24 [ [ -LRB- cord-335975-m6lkrehi 2733 25 4 4 CD cord-335975-m6lkrehi 2733 26 , , , cord-335975-m6lkrehi 2733 27 5 5 CD cord-335975-m6lkrehi 2733 28 ] ] -RRB- cord-335975-m6lkrehi 2733 29 for for IN cord-335975-m6lkrehi 2733 30 ARF arf NN cord-335975-m6lkrehi 2733 31 secondary secondary JJ cord-335975-m6lkrehi 2733 32 to to IN cord-335975-m6lkrehi 2733 33 cardiogenic cardiogenic JJ cord-335975-m6lkrehi 2733 34 ALE ale NN cord-335975-m6lkrehi 2733 35 . . . cord-335975-m6lkrehi 2734 1 The the DT cord-335975-m6lkrehi 2734 2 prevalence prevalence NN cord-335975-m6lkrehi 2734 3 of of IN cord-335975-m6lkrehi 2734 4 ARF arf NN cord-335975-m6lkrehi 2734 5 in in IN cord-335975-m6lkrehi 2734 6 Algeria Algeria NNP cord-335975-m6lkrehi 2734 7 remains remain VBZ cord-335975-m6lkrehi 2734 8 unknown unknown JJ cord-335975-m6lkrehi 2734 9 + + CC cord-335975-m6lkrehi 2734 10 the the DT cord-335975-m6lkrehi 2734 11 TAHINA TAHINA NNP cord-335975-m6lkrehi 2734 12 study study NN cord-335975-m6lkrehi 2734 13 showed show VBD cord-335975-m6lkrehi 2734 14 that that IN cord-335975-m6lkrehi 2734 15 respiratory respiratory JJ cord-335975-m6lkrehi 2734 16 diseases disease NNS cord-335975-m6lkrehi 2734 17 were be VBD cord-335975-m6lkrehi 2734 18 the the DT cord-335975-m6lkrehi 2734 19 leading leading JJ cord-335975-m6lkrehi 2734 20 cause cause NN cord-335975-m6lkrehi 2734 21 of of IN cord-335975-m6lkrehi 2734 22 consultation consultation NN cord-335975-m6lkrehi 2734 23 in in IN cord-335975-m6lkrehi 2734 24 the the DT cord-335975-m6lkrehi 2734 25 hospital hospital NN cord-335975-m6lkrehi 2734 26 [ [ -LRB- cord-335975-m6lkrehi 2734 27 2 2 CD cord-335975-m6lkrehi 2734 28 ] ] -RRB- cord-335975-m6lkrehi 2734 29 . . . cord-335975-m6lkrehi 2735 1 The the DT cord-335975-m6lkrehi 2735 2 The the DT cord-335975-m6lkrehi 2735 3 objective objective NN cord-335975-m6lkrehi 2735 4 of of IN cord-335975-m6lkrehi 2735 5 this this DT cord-335975-m6lkrehi 2735 6 study study NN cord-335975-m6lkrehi 2735 7 is be VBZ cord-335975-m6lkrehi 2735 8 to to TO cord-335975-m6lkrehi 2735 9 estimate estimate VB cord-335975-m6lkrehi 2735 10 the the DT cord-335975-m6lkrehi 2735 11 frequency frequency NN cord-335975-m6lkrehi 2735 12 of of IN cord-335975-m6lkrehi 2735 13 use use NN cord-335975-m6lkrehi 2735 14 of of IN cord-335975-m6lkrehi 2735 15 the the DT cord-335975-m6lkrehi 2735 16 NIV NIV NNP cord-335975-m6lkrehi 2735 17 and and CC cord-335975-m6lkrehi 2735 18 to to TO cord-335975-m6lkrehi 2735 19 determine determine VB cord-335975-m6lkrehi 2735 20 the the DT cord-335975-m6lkrehi 2735 21 associated associate VBN cord-335975-m6lkrehi 2735 22 factors factor NNS cord-335975-m6lkrehi 2735 23 of of IN cord-335975-m6lkrehi 2735 24 failure failure NN cord-335975-m6lkrehi 2735 25 of of IN cord-335975-m6lkrehi 2735 26 the the DT cord-335975-m6lkrehi 2735 27 NIV NIV NNP cord-335975-m6lkrehi 2735 28 for for IN cord-335975-m6lkrehi 2735 29 the the DT cord-335975-m6lkrehi 2735 30 adult adult NN cord-335975-m6lkrehi 2735 31 patients patient NNS cord-335975-m6lkrehi 2735 32 hospitalized hospitalize VBN cord-335975-m6lkrehi 2735 33 for for IN cord-335975-m6lkrehi 2735 34 ARF arf NN cord-335975-m6lkrehi 2735 35 in in IN cord-335975-m6lkrehi 2735 36 the the DT cord-335975-m6lkrehi 2735 37 emergency emergency NN cord-335975-m6lkrehi 2735 38 department department NN cord-335975-m6lkrehi 2735 39 of of IN cord-335975-m6lkrehi 2735 40 Oran Oran NNP cord-335975-m6lkrehi 2735 41 hospital hospital NN cord-335975-m6lkrehi 2735 42 from from IN cord-335975-m6lkrehi 2735 43 January January NNP cord-335975-m6lkrehi 2735 44 2015 2015 CD cord-335975-m6lkrehi 2735 45 to to IN cord-335975-m6lkrehi 2735 46 November November NNP cord-335975-m6lkrehi 2735 47 2016 2016 CD cord-335975-m6lkrehi 2735 48 . . . cord-335975-m6lkrehi 2736 1 Prevalence prevalence NN cord-335975-m6lkrehi 2736 2 of of IN cord-335975-m6lkrehi 2736 3 COPD COPD NNP cord-335975-m6lkrehi 2736 4 was be VBD cord-335975-m6lkrehi 2736 5 found find VBN cord-335975-m6lkrehi 2736 6 in in IN cord-335975-m6lkrehi 2736 7 the the DT cord-335975-m6lkrehi 2736 8 31.5 31.5 CD cord-335975-m6lkrehi 2736 9 % % NN cord-335975-m6lkrehi 2736 10 of of IN cord-335975-m6lkrehi 2736 11 tobacco tobacco NN cord-335975-m6lkrehi 2736 12 subjects subject NNS cord-335975-m6lkrehi 2736 13 [ [ -LRB- cord-335975-m6lkrehi 2736 14 3 3 CD cord-335975-m6lkrehi 2736 15 ] ] -RRB- cord-335975-m6lkrehi 2736 16 . . . cord-335975-m6lkrehi 2737 1 The the DT cord-335975-m6lkrehi 2737 2 number number NN cord-335975-m6lkrehi 2737 3 of of IN cord-335975-m6lkrehi 2737 4 patients patient NNS cord-335975-m6lkrehi 2737 5 hospitalized hospitalize VBN cord-335975-m6lkrehi 2737 6 for for IN cord-335975-m6lkrehi 2737 7 chest chest NN cord-335975-m6lkrehi 2737 8 trauma trauma NN cord-335975-m6lkrehi 2737 9 continues continue VBZ cord-335975-m6lkrehi 2737 10 to to TO cord-335975-m6lkrehi 2737 11 increase increase VB cord-335975-m6lkrehi 2737 12 , , , cord-335975-m6lkrehi 2737 13 resulting result VBG cord-335975-m6lkrehi 2737 14 in in IN cord-335975-m6lkrehi 2737 15 an an DT cord-335975-m6lkrehi 2737 16 increase increase NN cord-335975-m6lkrehi 2737 17 in in IN cord-335975-m6lkrehi 2737 18 the the DT cord-335975-m6lkrehi 2737 19 number number NN cord-335975-m6lkrehi 2737 20 of of IN cord-335975-m6lkrehi 2737 21 patients patient NNS cord-335975-m6lkrehi 2737 22 admitted admit VBN cord-335975-m6lkrehi 2737 23 for for IN cord-335975-m6lkrehi 2737 24 ARF arf NN cord-335975-m6lkrehi 2737 25 secondary secondary JJ cord-335975-m6lkrehi 2737 26 to to IN cord-335975-m6lkrehi 2737 27 chest chest NN cord-335975-m6lkrehi 2737 28 trauma trauma NN cord-335975-m6lkrehi 2737 29 . . . cord-335975-m6lkrehi 2738 1 Patients patient NNS cord-335975-m6lkrehi 2738 2 and and CC cord-335975-m6lkrehi 2738 3 methods method NNS cord-335975-m6lkrehi 2738 4 : : : cord-335975-m6lkrehi 2738 5 This this DT cord-335975-m6lkrehi 2738 6 is be VBZ cord-335975-m6lkrehi 2738 7 an an DT cord-335975-m6lkrehi 2738 8 observational observational JJ cord-335975-m6lkrehi 2738 9 and and CC cord-335975-m6lkrehi 2738 10 exhaustive exhaustive JJ cord-335975-m6lkrehi 2738 11 study study NN cord-335975-m6lkrehi 2738 12 during during IN cord-335975-m6lkrehi 2738 13 the the DT cord-335975-m6lkrehi 2738 14 month month NN cord-335975-m6lkrehi 2738 15 of of IN cord-335975-m6lkrehi 2738 16 November November NNP cord-335975-m6lkrehi 2738 17 , , , cord-335975-m6lkrehi 2738 18 from from IN cord-335975-m6lkrehi 2738 19 the the DT cord-335975-m6lkrehi 2738 20 files file NNS cord-335975-m6lkrehi 2738 21 of of IN cord-335975-m6lkrehi 2738 22 patients patient NNS cord-335975-m6lkrehi 2738 23 . . . cord-335975-m6lkrehi 2739 1 The the DT cord-335975-m6lkrehi 2739 2 population population NN cord-335975-m6lkrehi 2739 3 - - , cord-335975-m6lkrehi 2739 4 all all DT cord-335975-m6lkrehi 2739 5 subjects subject NNS cord-335975-m6lkrehi 2739 6 over over IN cord-335975-m6lkrehi 2739 7 16 16 CD cord-335975-m6lkrehi 2739 8 years year NNS cord-335975-m6lkrehi 2739 9 hospitalized hospitalize VBN cord-335975-m6lkrehi 2739 10 for for IN cord-335975-m6lkrehi 2739 11 an an DT cord-335975-m6lkrehi 2739 12 ARF arf NN cord-335975-m6lkrehi 2739 13 at at IN cord-335975-m6lkrehi 2739 14 the the DT cord-335975-m6lkrehi 2739 15 reception reception NN cord-335975-m6lkrehi 2739 16 and and CC cord-335975-m6lkrehi 2739 17 resuscitation resuscitation NN cord-335975-m6lkrehi 2739 18 units unit NNS cord-335975-m6lkrehi 2739 19 of of IN cord-335975-m6lkrehi 2739 20 the the DT cord-335975-m6lkrehi 2739 21 emergency emergency NN cord-335975-m6lkrehi 2739 22 department department NN cord-335975-m6lkrehi 2739 23 of of IN cord-335975-m6lkrehi 2739 24 Oran Oran NNP cord-335975-m6lkrehi 2739 25 Hospital Hospital NNP cord-335975-m6lkrehi 2739 26 from from IN cord-335975-m6lkrehi 2739 27 January January NNP cord-335975-m6lkrehi 2739 28 2015 2015 CD cord-335975-m6lkrehi 2739 29 to to IN cord-335975-m6lkrehi 2739 30 November November NNP cord-335975-m6lkrehi 2739 31 2016 2016 CD cord-335975-m6lkrehi 2739 32 . . . cord-335975-m6lkrehi 2740 1 Results result NNS cord-335975-m6lkrehi 2740 2 : : : cord-335975-m6lkrehi 2741 1 Ninety ninety CD cord-335975-m6lkrehi 2741 2 - - HYPH cord-335975-m6lkrehi 2741 3 seven seven CD cord-335975-m6lkrehi 2741 4 patients patient NNS cord-335975-m6lkrehi 2741 5 were be VBD cord-335975-m6lkrehi 2741 6 hospitalized hospitalize VBN cord-335975-m6lkrehi 2741 7 for for IN cord-335975-m6lkrehi 2741 8 ARF arf NN cord-335975-m6lkrehi 2741 9 during during IN cord-335975-m6lkrehi 2741 10 this this DT cord-335975-m6lkrehi 2741 11 period period NN cord-335975-m6lkrehi 2741 12 . . . cord-335975-m6lkrehi 2742 1 NIV NIV NNP cord-335975-m6lkrehi 2742 2 was be VBD cord-335975-m6lkrehi 2742 3 used use VBN cord-335975-m6lkrehi 2742 4 for for IN cord-335975-m6lkrehi 2742 5 37 37 CD cord-335975-m6lkrehi 2742 6 patients patient NNS cord-335975-m6lkrehi 2742 7 . . . cord-335975-m6lkrehi 2743 1 24 24 CD cord-335975-m6lkrehi 2743 2 patients patient NNS cord-335975-m6lkrehi 2743 3 were be VBD cord-335975-m6lkrehi 2743 4 acute acute JJ cord-335975-m6lkrehi 2743 5 lung lung NN cord-335975-m6lkrehi 2743 6 edema edema NN cord-335975-m6lkrehi 2743 7 . . . cord-335975-m6lkrehi 2744 1 Univariate Univariate NNP cord-335975-m6lkrehi 2744 2 analysis analysis NN cord-335975-m6lkrehi 2744 3 showed show VBD cord-335975-m6lkrehi 2744 4 that that IN cord-335975-m6lkrehi 2744 5 SPO2 SPO2 NNP cord-335975-m6lkrehi 2744 6 was be VBD cord-335975-m6lkrehi 2744 7 the the DT cord-335975-m6lkrehi 2744 8 only only JJ cord-335975-m6lkrehi 2744 9 failure failure NN cord-335975-m6lkrehi 2744 10 factor factor NN cord-335975-m6lkrehi 2744 11 in in IN cord-335975-m6lkrehi 2744 12 this this DT cord-335975-m6lkrehi 2744 13 series series NN cord-335975-m6lkrehi 2744 14 . . . cord-335975-m6lkrehi 2745 1 The the DT cord-335975-m6lkrehi 2745 2 failure failure NN cord-335975-m6lkrehi 2745 3 rate rate NN cord-335975-m6lkrehi 2745 4 of of IN cord-335975-m6lkrehi 2745 5 this this DT cord-335975-m6lkrehi 2745 6 technique technique NN cord-335975-m6lkrehi 2745 7 was be VBD cord-335975-m6lkrehi 2745 8 32.4 32.4 CD cord-335975-m6lkrehi 2745 9 % % NN cord-335975-m6lkrehi 2745 10 . . . cord-335975-m6lkrehi 2746 1 NIV NIV NNP cord-335975-m6lkrehi 2746 2 is be VBZ cord-335975-m6lkrehi 2746 3 a a DT cord-335975-m6lkrehi 2746 4 technique technique NN cord-335975-m6lkrehi 2746 5 that that WDT cord-335975-m6lkrehi 2746 6 should should MD cord-335975-m6lkrehi 2746 7 be be VB cord-335975-m6lkrehi 2746 8 used use VBN cord-335975-m6lkrehi 2746 9 more more JJR cord-335975-m6lkrehi 2746 10 in in IN cord-335975-m6lkrehi 2746 11 the the DT cord-335975-m6lkrehi 2746 12 emergency emergency NN cord-335975-m6lkrehi 2746 13 rooms room NNS cord-335975-m6lkrehi 2746 14 , , , cord-335975-m6lkrehi 2746 15 which which WDT cord-335975-m6lkrehi 2746 16 would would MD cord-335975-m6lkrehi 2746 17 make make VB cord-335975-m6lkrehi 2746 18 it -PRON- PRP cord-335975-m6lkrehi 2746 19 possible possible JJ cord-335975-m6lkrehi 2746 20 to to TO cord-335975-m6lkrehi 2746 21 use use VB cord-335975-m6lkrehi 2746 22 less less JJR cord-335975-m6lkrehi 2746 23 intubation intubation NN cord-335975-m6lkrehi 2746 24 specially specially RB cord-335975-m6lkrehi 2746 25 in in IN cord-335975-m6lkrehi 2746 26 indications indication NNS cord-335975-m6lkrehi 2746 27 where where WRB cord-335975-m6lkrehi 2746 28 the the DT cord-335975-m6lkrehi 2746 29 level level NN cord-335975-m6lkrehi 2746 30 of of IN cord-335975-m6lkrehi 2746 31 proof proof NN cord-335975-m6lkrehi 2746 32 in in IN cord-335975-m6lkrehi 2746 33 the the DT cord-335975-m6lkrehi 2746 34 literature literature NN cord-335975-m6lkrehi 2746 35 is be VBZ cord-335975-m6lkrehi 2746 36 important important JJ cord-335975-m6lkrehi 2746 37 . . . cord-335975-m6lkrehi 2747 1 demographic demographic JJ cord-335975-m6lkrehi 2747 2 characteristics characteristic NNS cord-335975-m6lkrehi 2747 3 , , , cord-335975-m6lkrehi 2747 4 etiology etiology NN cord-335975-m6lkrehi 2747 5 of of IN cord-335975-m6lkrehi 2747 6 exacerbation exacerbation NN cord-335975-m6lkrehi 2747 7 , , , cord-335975-m6lkrehi 2747 8 comorbidities comorbiditie NNS cord-335975-m6lkrehi 2747 9 , , , cord-335975-m6lkrehi 2747 10 the the DT cord-335975-m6lkrehi 2747 11 SAPSII SAPSII NNP cord-335975-m6lkrehi 2747 12 score score NN cord-335975-m6lkrehi 2747 13 , , , cord-335975-m6lkrehi 2747 14 arterial arterial JJ cord-335975-m6lkrehi 2747 15 blood blood NN cord-335975-m6lkrehi 2747 16 gases gas NNS cord-335975-m6lkrehi 2747 17 at at IN cord-335975-m6lkrehi 2747 18 admission admission NN cord-335975-m6lkrehi 2747 19 , , , cord-335975-m6lkrehi 2747 20 respiratory respiratory JJ cord-335975-m6lkrehi 2747 21 , , , cord-335975-m6lkrehi 2747 22 hemodynamic hemodynamic JJ cord-335975-m6lkrehi 2747 23 and and CC cord-335975-m6lkrehi 2747 24 neurological neurological JJ cord-335975-m6lkrehi 2747 25 parameters parameter NNS cord-335975-m6lkrehi 2747 26 , , , cord-335975-m6lkrehi 2747 27 use use NN cord-335975-m6lkrehi 2747 28 of of IN cord-335975-m6lkrehi 2747 29 noninvasive noninvasive JJ cord-335975-m6lkrehi 2747 30 or or CC cord-335975-m6lkrehi 2747 31 invasive invasive JJ cord-335975-m6lkrehi 2747 32 ventilation ventilation NN cord-335975-m6lkrehi 2747 33 , , , cord-335975-m6lkrehi 2747 34 nosocomial nosocomial JJ cord-335975-m6lkrehi 2747 35 infection infection NN cord-335975-m6lkrehi 2747 36 , , , cord-335975-m6lkrehi 2747 37 duration duration NN cord-335975-m6lkrehi 2747 38 of of IN cord-335975-m6lkrehi 2747 39 NIV NIV NNP cord-335975-m6lkrehi 2747 40 , , , cord-335975-m6lkrehi 2747 41 length length NN cord-335975-m6lkrehi 2747 42 of of IN cord-335975-m6lkrehi 2747 43 stay stay NN cord-335975-m6lkrehi 2747 44 and and CC cord-335975-m6lkrehi 2747 45 mortality mortality NN cord-335975-m6lkrehi 2747 46 . . . cord-335975-m6lkrehi 2748 1 Results result NNS cord-335975-m6lkrehi 2748 2 : : : cord-335975-m6lkrehi 2749 1 During during IN cord-335975-m6lkrehi 2749 2 period period NN cord-335975-m6lkrehi 2749 3 study study NN cord-335975-m6lkrehi 2749 4 160 160 CD cord-335975-m6lkrehi 2749 5 patients patient NNS cord-335975-m6lkrehi 2749 6 ( ( -LRB- cord-335975-m6lkrehi 2749 7 58 58 CD cord-335975-m6lkrehi 2749 8 % % NN cord-335975-m6lkrehi 2749 9 women woman NNS cord-335975-m6lkrehi 2749 10 with with IN cord-335975-m6lkrehi 2749 11 a a DT cord-335975-m6lkrehi 2749 12 SAPSII SAPSII NNP cord-335975-m6lkrehi 2749 13 score score NN cord-335975-m6lkrehi 2749 14 29 29 CD cord-335975-m6lkrehi 2749 15 ± ± NNP cord-335975-m6lkrehi 2749 16 15 15 CD cord-335975-m6lkrehi 2749 17 ) ) -RRB- cord-335975-m6lkrehi 2749 18 were be VBD cord-335975-m6lkrehi 2749 19 included include VBN cord-335975-m6lkrehi 2749 20 . . . cord-335975-m6lkrehi 2750 1 The the DT cord-335975-m6lkrehi 2750 2 etiology etiology NN cord-335975-m6lkrehi 2750 3 of of IN cord-335975-m6lkrehi 2750 4 exacerbation exacerbation NN cord-335975-m6lkrehi 2750 5 was be VBD cord-335975-m6lkrehi 2750 6 bronchitis bronchitis NN cord-335975-m6lkrehi 2750 7 in in IN cord-335975-m6lkrehi 2750 8 45 45 CD cord-335975-m6lkrehi 2750 9 % % NN cord-335975-m6lkrehi 2750 10 of of IN cord-335975-m6lkrehi 2750 11 cases case NNS cord-335975-m6lkrehi 2750 12 and and CC cord-335975-m6lkrehi 2750 13 pneumonia pneumonia NN cord-335975-m6lkrehi 2750 14 in in IN cord-335975-m6lkrehi 2750 15 40 40 CD cord-335975-m6lkrehi 2750 16 % % NN cord-335975-m6lkrehi 2750 17 . . . cord-335975-m6lkrehi 2751 1 Only only RB cord-335975-m6lkrehi 2751 2 3 3 CD cord-335975-m6lkrehi 2751 3 patients patient NNS cord-335975-m6lkrehi 2751 4 have have VBP cord-335975-m6lkrehi 2751 5 NIV NIV NNP cord-335975-m6lkrehi 2751 6 at at IN cord-335975-m6lkrehi 2751 7 home home NN cord-335975-m6lkrehi 2751 8 and and CC cord-335975-m6lkrehi 2751 9 6 6 CD cord-335975-m6lkrehi 2751 10 patients patient NNS cord-335975-m6lkrehi 2751 11 have have VBP cord-335975-m6lkrehi 2751 12 oxygen oxygen NN cord-335975-m6lkrehi 2751 13 . . . cord-335975-m6lkrehi 2752 1 Pseudomonas Pseudomonas NNP cord-335975-m6lkrehi 2752 2 aeruginosa aeruginosa NN cord-335975-m6lkrehi 2752 3 was be VBD cord-335975-m6lkrehi 2752 4 isolated isolate VBN cord-335975-m6lkrehi 2752 5 in in IN cord-335975-m6lkrehi 2752 6 6 6 CD cord-335975-m6lkrehi 2752 7 cases case NNS cord-335975-m6lkrehi 2752 8 . . . cord-335975-m6lkrehi 2753 1 Twenty twenty CD cord-335975-m6lkrehi 2753 2 percent percent NN cord-335975-m6lkrehi 2753 3 of of IN cord-335975-m6lkrehi 2753 4 the the DT cord-335975-m6lkrehi 2753 5 patients patient NNS cord-335975-m6lkrehi 2753 6 had have VBD cord-335975-m6lkrehi 2753 7 developed develop VBN cord-335975-m6lkrehi 2753 8 a a DT cord-335975-m6lkrehi 2753 9 nosocomial nosocomial JJ cord-335975-m6lkrehi 2753 10 infection infection NN cord-335975-m6lkrehi 2753 11 , , , cord-335975-m6lkrehi 2753 12 Acinetobacter Acinetobacter NNP cord-335975-m6lkrehi 2753 13 Baumanii Baumanii NNP cord-335975-m6lkrehi 2753 14 and and CC cord-335975-m6lkrehi 2753 15 Pseudomonas Pseudomonas NNP cord-335975-m6lkrehi 2753 16 aeruginosa aeruginosa NN cord-335975-m6lkrehi 2753 17 were be VBD cord-335975-m6lkrehi 2753 18 isolated isolate VBN cord-335975-m6lkrehi 2753 19 in in IN cord-335975-m6lkrehi 2753 20 60 60 CD cord-335975-m6lkrehi 2753 21 and and CC cord-335975-m6lkrehi 2753 22 25 25 CD cord-335975-m6lkrehi 2753 23 % % NN cord-335975-m6lkrehi 2753 24 respectively respectively RB cord-335975-m6lkrehi 2753 25 . . . cord-335975-m6lkrehi 2754 1 NIV NIV NNP cord-335975-m6lkrehi 2754 2 was be VBD cord-335975-m6lkrehi 2754 3 used use VBN cord-335975-m6lkrehi 2754 4 in in IN cord-335975-m6lkrehi 2754 5 89 89 CD cord-335975-m6lkrehi 2754 6 patients patient NNS cord-335975-m6lkrehi 2754 7 at at IN cord-335975-m6lkrehi 2754 8 admission admission NN cord-335975-m6lkrehi 2754 9 and and CC cord-335975-m6lkrehi 2754 10 the the DT cord-335975-m6lkrehi 2754 11 rate rate NN cord-335975-m6lkrehi 2754 12 of of IN cord-335975-m6lkrehi 2754 13 NIV NIV NNP cord-335975-m6lkrehi 2754 14 failure failure NN cord-335975-m6lkrehi 2754 15 was be VBD cord-335975-m6lkrehi 2754 16 29 29 CD cord-335975-m6lkrehi 2754 17 % % NN cord-335975-m6lkrehi 2754 18 . . . cord-335975-m6lkrehi 2755 1 The the DT cord-335975-m6lkrehi 2755 2 duration duration NN cord-335975-m6lkrehi 2755 3 of of IN cord-335975-m6lkrehi 2755 4 mechanical mechanical JJ cord-335975-m6lkrehi 2755 5 ventilation ventilation NN cord-335975-m6lkrehi 2755 6 was be VBD cord-335975-m6lkrehi 2755 7 9 9 CD cord-335975-m6lkrehi 2755 8 ± ± NNP cord-335975-m6lkrehi 2755 9 8 8 CD cord-335975-m6lkrehi 2755 10 days day NNS cord-335975-m6lkrehi 2755 11 and and CC cord-335975-m6lkrehi 2756 1 the the DT cord-335975-m6lkrehi 2756 2 length length NN cord-335975-m6lkrehi 2756 3 of of IN cord-335975-m6lkrehi 2756 4 stay stay NN cord-335975-m6lkrehi 2756 5 was be VBD cord-335975-m6lkrehi 2756 6 12 12 CD cord-335975-m6lkrehi 2756 7 ± ± CD cord-335975-m6lkrehi 2756 8 10 10 CD cord-335975-m6lkrehi 2756 9 days day NNS cord-335975-m6lkrehi 2756 10 . . . cord-335975-m6lkrehi 2757 1 The the DT cord-335975-m6lkrehi 2757 2 mortality mortality NN cord-335975-m6lkrehi 2757 3 was be VBD cord-335975-m6lkrehi 2757 4 12 12 CD cord-335975-m6lkrehi 2757 5 % % NN cord-335975-m6lkrehi 2757 6 . . . cord-335975-m6lkrehi 2758 1 NIV NIV NNP cord-335975-m6lkrehi 2758 2 and and CC cord-335975-m6lkrehi 2758 3 oxygen oxygen NN cord-335975-m6lkrehi 2758 4 at at IN cord-335975-m6lkrehi 2758 5 home home NN cord-335975-m6lkrehi 2758 6 were be VBD cord-335975-m6lkrehi 2758 7 prescribed prescribe VBN cord-335975-m6lkrehi 2758 8 for for IN cord-335975-m6lkrehi 2758 9 21 21 CD cord-335975-m6lkrehi 2758 10 patients patient NNS cord-335975-m6lkrehi 2758 11 . . . cord-335975-m6lkrehi 2759 1 In in IN cord-335975-m6lkrehi 2759 2 univariate univariate JJ cord-335975-m6lkrehi 2759 3 analysis analysis NN cord-335975-m6lkrehi 2759 4 survivors survivor NNS cord-335975-m6lkrehi 2759 5 and and CC cord-335975-m6lkrehi 2759 6 non non NNS cord-335975-m6lkrehi 2759 7 - - NNS cord-335975-m6lkrehi 2759 8 survivors survivor NNS cord-335975-m6lkrehi 2759 9 were be VBD cord-335975-m6lkrehi 2759 10 comparable comparable JJ cord-335975-m6lkrehi 2759 11 regarding regard VBG cord-335975-m6lkrehi 2759 12 baseline baseline JJ cord-335975-m6lkrehi 2759 13 and and CC cord-335975-m6lkrehi 2759 14 clinical clinical JJ cord-335975-m6lkrehi 2759 15 characteristics characteristic NNS cord-335975-m6lkrehi 2759 16 . . . cord-335975-m6lkrehi 2760 1 Nosocomial nosocomial JJ cord-335975-m6lkrehi 2760 2 infections infection NNS cord-335975-m6lkrehi 2760 3 ( ( -LRB- cord-335975-m6lkrehi 2760 4 53 53 CD cord-335975-m6lkrehi 2760 5 vs. vs. CC cord-335975-m6lkrehi 2760 6 16 16 CD cord-335975-m6lkrehi 2760 7 % % NN cord-335975-m6lkrehi 2760 8 ) ) -RRB- cord-335975-m6lkrehi 2760 9 , , , cord-335975-m6lkrehi 2760 10 and and CC cord-335975-m6lkrehi 2760 11 SPASSII SPASSII NNP cord-335975-m6lkrehi 2760 12 score score NN cord-335975-m6lkrehi 2760 13 were be VBD cord-335975-m6lkrehi 2760 14 significantly significantly RB cord-335975-m6lkrehi 2760 15 more more RBR cord-335975-m6lkrehi 2760 16 elevated elevated JJ cord-335975-m6lkrehi 2760 17 in in IN cord-335975-m6lkrehi 2760 18 non non NNS cord-335975-m6lkrehi 2760 19 - - NNS cord-335975-m6lkrehi 2760 20 survivors survivor NNS cord-335975-m6lkrehi 2760 21 . . . cord-335975-m6lkrehi 2760 22 _SP cord-335975-m6lkrehi 2761 1 In in IN cord-335975-m6lkrehi 2761 2 emergency emergency NN cord-335975-m6lkrehi 2761 3 department department NN cord-335975-m6lkrehi 2761 4 , , , cord-335975-m6lkrehi 2761 5 the the DT cord-335975-m6lkrehi 2761 6 management management NN cord-335975-m6lkrehi 2761 7 of of IN cord-335975-m6lkrehi 2761 8 hypercapnic hypercapnic NNP cord-335975-m6lkrehi 2761 9 acute acute JJ cord-335975-m6lkrehi 2761 10 respiratory respiratory JJ cord-335975-m6lkrehi 2761 11 failure failure NN cord-335975-m6lkrehi 2761 12 with with IN cord-335975-m6lkrehi 2761 13 HFO HFO NNP cord-335975-m6lkrehi 2761 14 is be VBZ cord-335975-m6lkrehi 2761 15 limited limit VBN cord-335975-m6lkrehi 2761 16 . . . cord-335975-m6lkrehi 2762 1 Hypercapnia Hypercapnia NNP cord-335975-m6lkrehi 2762 2 and and CC cord-335975-m6lkrehi 2762 3 acidosis acidosis NN cord-335975-m6lkrehi 2762 4 remain remain VBP cord-335975-m6lkrehi 2762 5 moderate moderate JJ cord-335975-m6lkrehi 2762 6 . . . cord-335975-m6lkrehi 2763 1 Patients patient NNS cord-335975-m6lkrehi 2763 2 are be VBP cord-335975-m6lkrehi 2763 3 old old JJ cord-335975-m6lkrehi 2763 4 with with IN cord-335975-m6lkrehi 2763 5 comorbidities comorbiditie NNS cord-335975-m6lkrehi 2763 6 . . . cord-335975-m6lkrehi 2764 1 The the DT cord-335975-m6lkrehi 2764 2 mortality mortality NN cord-335975-m6lkrehi 2764 3 rate rate NN cord-335975-m6lkrehi 2764 4 is be VBZ cord-335975-m6lkrehi 2764 5 high high JJ cord-335975-m6lkrehi 2764 6 but but CC cord-335975-m6lkrehi 2764 7 expected expect VBN cord-335975-m6lkrehi 2764 8 given give VBN cord-335975-m6lkrehi 2764 9 the the DT cord-335975-m6lkrehi 2764 10 number number NN cord-335975-m6lkrehi 2764 11 of of IN cord-335975-m6lkrehi 2764 12 limitation limitation NN cord-335975-m6lkrehi 2764 13 of of IN cord-335975-m6lkrehi 2764 14 active active JJ cord-335975-m6lkrehi 2764 15 therapy therapy NN cord-335975-m6lkrehi 2764 16 . . . cord-335975-m6lkrehi 2765 1 HFO HFO NNP cord-335975-m6lkrehi 2765 2 appears appear VBZ cord-335975-m6lkrehi 2765 3 to to TO cord-335975-m6lkrehi 2765 4 be be VB cord-335975-m6lkrehi 2765 5 effective effective JJ cord-335975-m6lkrehi 2765 6 for for IN cord-335975-m6lkrehi 2765 7 a a DT cord-335975-m6lkrehi 2765 8 majority majority NN cord-335975-m6lkrehi 2765 9 of of IN cord-335975-m6lkrehi 2765 10 patients patient NNS cord-335975-m6lkrehi 2765 11 , , , cord-335975-m6lkrehi 2765 12 but but CC cord-335975-m6lkrehi 2765 13 half half NN cord-335975-m6lkrehi 2765 14 of of IN cord-335975-m6lkrehi 2765 15 them -PRON- PRP cord-335975-m6lkrehi 2765 16 required require VBD cord-335975-m6lkrehi 2765 17 NIV NIV NNP cord-335975-m6lkrehi 2765 18 too too RB cord-335975-m6lkrehi 2765 19 . . . cord-335975-m6lkrehi 2766 1 The the DT cord-335975-m6lkrehi 2766 2 NIV NIV NNP cord-335975-m6lkrehi 2766 3 HFO HFO NNP cord-335975-m6lkrehi 2766 4 association association NN cord-335975-m6lkrehi 2766 5 seems seem VBZ cord-335975-m6lkrehi 2766 6 an an DT cord-335975-m6lkrehi 2766 7 interesting interesting JJ cord-335975-m6lkrehi 2766 8 option option NN cord-335975-m6lkrehi 2766 9 . . . cord-335975-m6lkrehi 2767 1 But but CC cord-335975-m6lkrehi 2767 2 our -PRON- PRP$ cord-335975-m6lkrehi 2767 3 methodology methodology NN cord-335975-m6lkrehi 2767 4 is be VBZ cord-335975-m6lkrehi 2767 5 perfectible perfectible JJ cord-335975-m6lkrehi 2767 6 and and CC cord-335975-m6lkrehi 2767 7 would would MD cord-335975-m6lkrehi 2767 8 require require VB cord-335975-m6lkrehi 2767 9 a a DT cord-335975-m6lkrehi 2767 10 randomized randomized JJ cord-335975-m6lkrehi 2767 11 control control NN cord-335975-m6lkrehi 2767 12 tria tria NNP cord-335975-m6lkrehi 2767 13 . . . cord-335975-m6lkrehi 2768 1 Severe severe JJ cord-335975-m6lkrehi 2768 2 chronic chronic JJ cord-335975-m6lkrehi 2768 3 obstructive obstructive JJ cord-335975-m6lkrehi 2768 4 pulmonary pulmonary JJ cord-335975-m6lkrehi 2768 5 disease disease NN cord-335975-m6lkrehi 2768 6 with with IN cord-335975-m6lkrehi 2768 7 chronic chronic JJ cord-335975-m6lkrehi 2768 8 respiratory respiratory JJ cord-335975-m6lkrehi 2768 9 failure failure NN cord-335975-m6lkrehi 2768 10 in in IN cord-335975-m6lkrehi 2768 11 intensive intensive JJ cord-335975-m6lkrehi 2768 12 care care NN cord-335975-m6lkrehi 2768 13 unit unit NN cord-335975-m6lkrehi 2768 14 : : : cord-335975-m6lkrehi 2768 15 mortality mortality NN cord-335975-m6lkrehi 2768 16 and and CC cord-335975-m6lkrehi 2768 17 prognostic prognostic JJ cord-335975-m6lkrehi 2768 18 factors factor NNS cord-335975-m6lkrehi 2769 1 Arnout arnout IN cord-335975-m6lkrehi 2769 2 Chloé Chloé NNP cord-335975-m6lkrehi 2769 3 1 1 CD cord-335975-m6lkrehi 2769 4 , , , cord-335975-m6lkrehi 2769 5 Faure Faure NNP cord-335975-m6lkrehi 2769 6 Morgane Morgane NNP cord-335975-m6lkrehi 2769 7 1 1 CD cord-335975-m6lkrehi 2769 8 , , , cord-335975-m6lkrehi 2769 9 Novy Novy NNP cord-335975-m6lkrehi 2769 10 Emmanuel Emmanuel NNP cord-335975-m6lkrehi 2769 11 1 1 CD cord-335975-m6lkrehi 2769 12 CHU CHU NNP cord-335975-m6lkrehi 2769 13 Nancy Nancy NNP cord-335975-m6lkrehi 2769 14 , , , cord-335975-m6lkrehi 2769 15 Nancy Nancy NNP cord-335975-m6lkrehi 2770 1 , , , cord-335975-m6lkrehi 2770 2 France France NNP cord-335975-m6lkrehi 2770 3 Correspondence Correspondence NNP cord-335975-m6lkrehi 2770 4 : : : cord-335975-m6lkrehi 2771 1 Arnout arnout IN cord-335975-m6lkrehi 2771 2 Chloé Chloé NNP cord-335975-m6lkrehi 2771 3 -arnout.chloe@gmail.com -arnout.chloe@gmail.com HYPH cord-335975-m6lkrehi 2771 4 Introduction introduction NN cord-335975-m6lkrehi 2771 5 : : : cord-335975-m6lkrehi 2772 1 Last last JJ cord-335975-m6lkrehi 2772 2 decades decade NNS cord-335975-m6lkrehi 2772 3 , , , cord-335975-m6lkrehi 2772 4 the the DT cord-335975-m6lkrehi 2772 5 number number NN cord-335975-m6lkrehi 2772 6 of of IN cord-335975-m6lkrehi 2772 7 patient patient NN cord-335975-m6lkrehi 2772 8 with with IN cord-335975-m6lkrehi 2772 9 chronic chronic JJ cord-335975-m6lkrehi 2772 10 respiratory respiratory JJ cord-335975-m6lkrehi 2772 11 failure failure NN cord-335975-m6lkrehi 2772 12 due due JJ cord-335975-m6lkrehi 2772 13 to to IN cord-335975-m6lkrehi 2772 14 chronic chronic JJ cord-335975-m6lkrehi 2772 15 obstructive obstructive JJ cord-335975-m6lkrehi 2772 16 pulmonary pulmonary JJ cord-335975-m6lkrehi 2772 17 disease disease NN cord-335975-m6lkrehi 2772 18 ( ( -LRB- cord-335975-m6lkrehi 2772 19 COPD COPD NNP cord-335975-m6lkrehi 2772 20 ) ) -RRB- cord-335975-m6lkrehi 2772 21 admitted admit VBD cord-335975-m6lkrehi 2772 22 in in IN cord-335975-m6lkrehi 2772 23 intensive intensive JJ cord-335975-m6lkrehi 2772 24 care care NN cord-335975-m6lkrehi 2772 25 unit unit NN cord-335975-m6lkrehi 2772 26 ( ( -LRB- cord-335975-m6lkrehi 2772 27 ICU ICU NNP cord-335975-m6lkrehi 2772 28 ) ) -RRB- cord-335975-m6lkrehi 2772 29 increased increase VBD cord-335975-m6lkrehi 2772 30 . . . cord-335975-m6lkrehi 2773 1 Data datum NNS cord-335975-m6lkrehi 2773 2 about about IN cord-335975-m6lkrehi 2773 3 their -PRON- PRP$ cord-335975-m6lkrehi 2773 4 real real JJ cord-335975-m6lkrehi 2773 5 prognosis prognosis NN cord-335975-m6lkrehi 2773 6 in in IN cord-335975-m6lkrehi 2773 7 the the DT cord-335975-m6lkrehi 2773 8 ICU ICU NNP cord-335975-m6lkrehi 2773 9 are be VBP cord-335975-m6lkrehi 2773 10 lacking lack VBG cord-335975-m6lkrehi 2773 11 . . . cord-335975-m6lkrehi 2774 1 The the DT cord-335975-m6lkrehi 2774 2 objective objective NN cord-335975-m6lkrehi 2774 3 of of IN cord-335975-m6lkrehi 2774 4 this this DT cord-335975-m6lkrehi 2774 5 study study NN cord-335975-m6lkrehi 2774 6 was be VBD cord-335975-m6lkrehi 2774 7 to to TO cord-335975-m6lkrehi 2774 8 evaluate evaluate VB cord-335975-m6lkrehi 2774 9 mortality mortality NN cord-335975-m6lkrehi 2774 10 rate rate NN cord-335975-m6lkrehi 2774 11 at at IN cord-335975-m6lkrehi 2774 12 6 6 CD cord-335975-m6lkrehi 2774 13 months month NNS cord-335975-m6lkrehi 2774 14 and and CC cord-335975-m6lkrehi 2774 15 to to TO cord-335975-m6lkrehi 2774 16 identify identify VB cord-335975-m6lkrehi 2774 17 prognostic prognostic JJ cord-335975-m6lkrehi 2774 18 factors factor NNS cord-335975-m6lkrehi 2774 19 of of IN cord-335975-m6lkrehi 2774 20 COPD COPD NNP cord-335975-m6lkrehi 2774 21 patients patient NNS cord-335975-m6lkrehi 2774 22 with with IN cord-335975-m6lkrehi 2774 23 chronic chronic JJ cord-335975-m6lkrehi 2774 24 respiratory respiratory JJ cord-335975-m6lkrehi 2774 25 failure failure NN cord-335975-m6lkrehi 2774 26 , , , cord-335975-m6lkrehi 2774 27 treated treat VBN cord-335975-m6lkrehi 2774 28 with with IN cord-335975-m6lkrehi 2774 29 long long JJ cord-335975-m6lkrehi 2774 30 term term NN cord-335975-m6lkrehi 2774 31 oxygen oxygen NN cord-335975-m6lkrehi 2774 32 therapy therapy NN cord-335975-m6lkrehi 2774 33 ( ( -LRB- cord-335975-m6lkrehi 2774 34 LTOT LTOT NNP cord-335975-m6lkrehi 2774 35 ) ) -RRB- cord-335975-m6lkrehi 2774 36 , , , cord-335975-m6lkrehi 2774 37 admitted admit VBN cord-335975-m6lkrehi 2774 38 in in IN cord-335975-m6lkrehi 2774 39 ICU ICU NNP cord-335975-m6lkrehi 2774 40 . . . cord-335975-m6lkrehi 2775 1 Patients patient NNS cord-335975-m6lkrehi 2775 2 and and CC cord-335975-m6lkrehi 2775 3 methods method NNS cord-335975-m6lkrehi 2775 4 : : : cord-335975-m6lkrehi 2775 5 A a DT cord-335975-m6lkrehi 2775 6 retrospective retrospective JJ cord-335975-m6lkrehi 2775 7 cohort cohort NN cord-335975-m6lkrehi 2775 8 study study NN cord-335975-m6lkrehi 2775 9 was be VBD cord-335975-m6lkrehi 2775 10 conducted conduct VBN cord-335975-m6lkrehi 2775 11 in in IN cord-335975-m6lkrehi 2775 12 the the DT cord-335975-m6lkrehi 2775 13 French french JJ cord-335975-m6lkrehi 2775 14 university university NN cord-335975-m6lkrehi 2775 15 hospital hospital NN cord-335975-m6lkrehi 2775 16 of of IN cord-335975-m6lkrehi 2775 17 Nancy Nancy NNP cord-335975-m6lkrehi 2775 18 during during IN cord-335975-m6lkrehi 2775 19 years year NNS cord-335975-m6lkrehi 2775 20 2014 2014 CD cord-335975-m6lkrehi 2775 21 - - SYM cord-335975-m6lkrehi 2775 22 2015 2015 CD cord-335975-m6lkrehi 2775 23 on on IN cord-335975-m6lkrehi 2775 24 all all DT cord-335975-m6lkrehi 2775 25 COPD COPD NNP cord-335975-m6lkrehi 2775 26 patients patient NNS cord-335975-m6lkrehi 2775 27 treated treat VBN cord-335975-m6lkrehi 2775 28 with with IN cord-335975-m6lkrehi 2775 29 LTOT LTOT NNP cord-335975-m6lkrehi 2775 30 admitted admit VBD cord-335975-m6lkrehi 2775 31 in in IN cord-335975-m6lkrehi 2775 32 ICU ICU NNP cord-335975-m6lkrehi 2775 33 . . . cord-335975-m6lkrehi 2776 1 Only only RB cord-335975-m6lkrehi 2776 2 the the DT cord-335975-m6lkrehi 2776 3 first first JJ cord-335975-m6lkrehi 2776 4 admission admission NN cord-335975-m6lkrehi 2776 5 was be VBD cord-335975-m6lkrehi 2776 6 analysed analyse VBN cord-335975-m6lkrehi 2776 7 . . . cord-335975-m6lkrehi 2777 1 Patients patient NNS cord-335975-m6lkrehi 2777 2 were be VBD cord-335975-m6lkrehi 2777 3 included include VBN cord-335975-m6lkrehi 2777 4 if if IN cord-335975-m6lkrehi 2777 5 they -PRON- PRP cord-335975-m6lkrehi 2777 6 had have VBD cord-335975-m6lkrehi 2777 7 spirometry spirometry NN cord-335975-m6lkrehi 2777 8 , , , cord-335975-m6lkrehi 2777 9 blood blood NN cord-335975-m6lkrehi 2777 10 gas gas NN cord-335975-m6lkrehi 2777 11 and and CC cord-335975-m6lkrehi 2777 12 oxygen oxygen NN cord-335975-m6lkrehi 2777 13 flow flow NN cord-335975-m6lkrehi 2777 14 in in IN cord-335975-m6lkrehi 2777 15 the the DT cord-335975-m6lkrehi 2777 16 year year NN cord-335975-m6lkrehi 2777 17 before before IN cord-335975-m6lkrehi 2777 18 admission admission NN cord-335975-m6lkrehi 2777 19 in in IN cord-335975-m6lkrehi 2777 20 ICU ICU NNP cord-335975-m6lkrehi 2777 21 . . . cord-335975-m6lkrehi 2778 1 Other other JJ cord-335975-m6lkrehi 2778 2 causes cause NNS cord-335975-m6lkrehi 2778 3 of of IN cord-335975-m6lkrehi 2778 4 chronic chronic JJ cord-335975-m6lkrehi 2778 5 respiratory respiratory JJ cord-335975-m6lkrehi 2778 6 failure failure NN cord-335975-m6lkrehi 2778 7 , , , cord-335975-m6lkrehi 2778 8 and and CC cord-335975-m6lkrehi 2778 9 patients patient NNS cord-335975-m6lkrehi 2778 10 with with IN cord-335975-m6lkrehi 2778 11 tracheostomy tracheostomy NN cord-335975-m6lkrehi 2778 12 before before IN cord-335975-m6lkrehi 2778 13 ICU ICU NNP cord-335975-m6lkrehi 2778 14 admission admission NN cord-335975-m6lkrehi 2778 15 were be VBD cord-335975-m6lkrehi 2778 16 excluded exclude VBN cord-335975-m6lkrehi 2778 17 of of IN cord-335975-m6lkrehi 2778 18 the the DT cord-335975-m6lkrehi 2778 19 cohort cohort NN cord-335975-m6lkrehi 2778 20 . . . cord-335975-m6lkrehi 2779 1 Hospitalizations hospitalization NNS cord-335975-m6lkrehi 2779 2 were be VBD cord-335975-m6lkrehi 2779 3 selected select VBN cord-335975-m6lkrehi 2779 4 using use VBG cord-335975-m6lkrehi 2779 5 the the DT cord-335975-m6lkrehi 2779 6 International International NNP cord-335975-m6lkrehi 2779 7 Classification Classification NNP cord-335975-m6lkrehi 2779 8 of of IN cord-335975-m6lkrehi 2779 9 Diseases Diseases NNPS cord-335975-m6lkrehi 2779 10 , , , cord-335975-m6lkrehi 2779 11 10 10 CD cord-335975-m6lkrehi 2779 12 th th XX cord-335975-m6lkrehi 2779 13 revision revision NN cord-335975-m6lkrehi 2779 14 ( ( -LRB- cord-335975-m6lkrehi 2779 15 ICD-10 ICD-10 NNP cord-335975-m6lkrehi 2779 16 ) ) -RRB- cord-335975-m6lkrehi 2779 17 . . . cord-335975-m6lkrehi 2780 1 Results result NNS cord-335975-m6lkrehi 2780 2 : : : cord-335975-m6lkrehi 2781 1 One one CD cord-335975-m6lkrehi 2781 2 hundred hundred CD cord-335975-m6lkrehi 2781 3 and and CC cord-335975-m6lkrehi 2781 4 thirteen thirteen CD cord-335975-m6lkrehi 2781 5 patients patient NNS cord-335975-m6lkrehi 2781 6 were be VBD cord-335975-m6lkrehi 2781 7 included include VBN cord-335975-m6lkrehi 2781 8 , , , cord-335975-m6lkrehi 2781 9 37 37 CD cord-335975-m6lkrehi 2781 10 ( ( -LRB- cord-335975-m6lkrehi 2781 11 33 33 CD cord-335975-m6lkrehi 2781 12 % % NN cord-335975-m6lkrehi 2781 13 ) ) -RRB- cord-335975-m6lkrehi 2781 14 died die VBD cord-335975-m6lkrehi 2781 15 in in IN cord-335975-m6lkrehi 2781 16 the the DT cord-335975-m6lkrehi 2781 17 first first JJ cord-335975-m6lkrehi 2781 18 6 6 CD cord-335975-m6lkrehi 2781 19 months month NNS cord-335975-m6lkrehi 2781 20 after after IN cord-335975-m6lkrehi 2781 21 ICU ICU NNP cord-335975-m6lkrehi 2781 22 admission admission NN cord-335975-m6lkrehi 2781 23 . . . cord-335975-m6lkrehi 2782 1 Mortality mortality NN cord-335975-m6lkrehi 2782 2 rate rate NN cord-335975-m6lkrehi 2782 3 in in IN cord-335975-m6lkrehi 2782 4 ICU ICU NNP cord-335975-m6lkrehi 2782 5 was be VBD cord-335975-m6lkrehi 2782 6 10 10 CD cord-335975-m6lkrehi 2782 7 % % NN cord-335975-m6lkrehi 2782 8 . . . cord-335975-m6lkrehi 2783 1 Severity severity NN cord-335975-m6lkrehi 2783 2 of of IN cord-335975-m6lkrehi 2783 3 COPD COPD NNP cord-335975-m6lkrehi 2783 4 was be VBD cord-335975-m6lkrehi 2783 5 - - HYPH cord-335975-m6lkrehi 2783 6 mean mean JJ cord-335975-m6lkrehi 2783 7 BODE BODE NNP cord-335975-m6lkrehi 2783 8 score score NN cord-335975-m6lkrehi 2783 9 7 7 CD cord-335975-m6lkrehi 2783 10 ± ± NNP cord-335975-m6lkrehi 2783 11 2.1 2.1 CD cord-335975-m6lkrehi 2783 12 , , , cord-335975-m6lkrehi 2783 13 number number NN cord-335975-m6lkrehi 2783 14 of of IN cord-335975-m6lkrehi 2783 15 exacerbation exacerbation NN cord-335975-m6lkrehi 2783 16 per per IN cord-335975-m6lkrehi 2783 17 year year NN cord-335975-m6lkrehi 2783 18 requiring require VBG cord-335975-m6lkrehi 2783 19 hospitalization hospitalization NN cord-335975-m6lkrehi 2783 20 3 3 CD cord-335975-m6lkrehi 2783 21 ± ± NNP cord-335975-m6lkrehi 2783 22 1.4 1.4 CD cord-335975-m6lkrehi 2783 23 . . . cord-335975-m6lkrehi 2784 1 LTOT LTOT NNP cord-335975-m6lkrehi 2784 2 was be VBD cord-335975-m6lkrehi 2784 3 used use VBN cord-335975-m6lkrehi 2784 4 for for IN cord-335975-m6lkrehi 2784 5 3.7 3.7 CD cord-335975-m6lkrehi 2784 6 ± ± CD cord-335975-m6lkrehi 2784 7 3.3 3.3 CD cord-335975-m6lkrehi 2784 8 years year NNS cord-335975-m6lkrehi 2784 9 . . . cord-335975-m6lkrehi 2785 1 Acute acute JJ cord-335975-m6lkrehi 2785 2 respiratory respiratory JJ cord-335975-m6lkrehi 2785 3 failure failure NN cord-335975-m6lkrehi 2785 4 was be VBD cord-335975-m6lkrehi 2785 5 the the DT cord-335975-m6lkrehi 2785 6 main main JJ cord-335975-m6lkrehi 2785 7 frequent frequent JJ cord-335975-m6lkrehi 2785 8 cause-38 cause-38 CD cord-335975-m6lkrehi 2785 9 % % NN cord-335975-m6lkrehi 2785 10 pneumonia pneumonia NN cord-335975-m6lkrehi 2785 11 , , , cord-335975-m6lkrehi 2785 12 34 34 CD cord-335975-m6lkrehi 2785 13 % % NN cord-335975-m6lkrehi 2785 14 acute acute JJ cord-335975-m6lkrehi 2785 15 exacerbation exacerbation NN cord-335975-m6lkrehi 2785 16 of of IN cord-335975-m6lkrehi 2785 17 COPD COPD NNP cord-335975-m6lkrehi 2785 18 , , , cord-335975-m6lkrehi 2785 19 14 14 CD cord-335975-m6lkrehi 2785 20 % % NN cord-335975-m6lkrehi 2785 21 acute acute JJ cord-335975-m6lkrehi 2785 22 lung lung NN cord-335975-m6lkrehi 2785 23 oedema oedema NN cord-335975-m6lkrehi 2785 24 . . . cord-335975-m6lkrehi 2786 1 The the DT cord-335975-m6lkrehi 2786 2 Sequential Sequential NNP cord-335975-m6lkrehi 2786 3 Organ Organ NNP cord-335975-m6lkrehi 2786 4 Failure Failure NNP cord-335975-m6lkrehi 2786 5 Assessment Assessment NNP cord-335975-m6lkrehi 2786 6 score score NN cord-335975-m6lkrehi 2786 7 within within IN cord-335975-m6lkrehi 2786 8 the the DT cord-335975-m6lkrehi 2786 9 first first JJ cord-335975-m6lkrehi 2786 10 24 24 CD cord-335975-m6lkrehi 2786 11 h h NN cord-335975-m6lkrehi 2786 12 of of IN cord-335975-m6lkrehi 2786 13 ICU ICU NNP cord-335975-m6lkrehi 2786 14 admission admission NN cord-335975-m6lkrehi 2786 15 was be VBD cord-335975-m6lkrehi 2786 16 11 11 CD cord-335975-m6lkrehi 2786 17 ± ± NNP cord-335975-m6lkrehi 2786 18 4 4 CD cord-335975-m6lkrehi 2786 19 . . . cord-335975-m6lkrehi 2787 1 Need need VB cord-335975-m6lkrehi 2787 2 for for IN cord-335975-m6lkrehi 2787 3 mechanical mechanical JJ cord-335975-m6lkrehi 2787 4 ventilation ventilation NN cord-335975-m6lkrehi 2787 5 was be VBD cord-335975-m6lkrehi 2787 6 noted note VBN cord-335975-m6lkrehi 2787 7 in in IN cord-335975-m6lkrehi 2787 8 22 22 CD cord-335975-m6lkrehi 2787 9 % % NN cord-335975-m6lkrehi 2787 10 of of IN cord-335975-m6lkrehi 2787 11 cases case NNS cord-335975-m6lkrehi 2787 12 and and CC cord-335975-m6lkrehi 2787 13 was be VBD cord-335975-m6lkrehi 2787 14 associated associate VBN cord-335975-m6lkrehi 2787 15 to to IN cord-335975-m6lkrehi 2787 16 mortality mortality NN cord-335975-m6lkrehi 2787 17 with with IN cord-335975-m6lkrehi 2787 18 an an DT cord-335975-m6lkrehi 2787 19 Odds Odds NNPS cord-335975-m6lkrehi 2787 20 Ratio Ratio NNP cord-335975-m6lkrehi 2787 21 of of IN cord-335975-m6lkrehi 2787 22 3.5 3.5 CD cord-335975-m6lkrehi 2787 23 ( ( -LRB- cord-335975-m6lkrehi 2787 24 CI CI NNP cord-335975-m6lkrehi 2787 25 95 95 CD cord-335975-m6lkrehi 2787 26 % % NN cord-335975-m6lkrehi 2787 27 [ [ -LRB- cord-335975-m6lkrehi 2787 28 1.4 1.4 CD cord-335975-m6lkrehi 2787 29 - - SYM cord-335975-m6lkrehi 2787 30 9 9 CD cord-335975-m6lkrehi 2787 31 ] ] -RRB- cord-335975-m6lkrehi 2787 32 p p NN cord-335975-m6lkrehi 2787 33 = = SYM cord-335975-m6lkrehi 2787 34 0.01 0.01 CD cord-335975-m6lkrehi 2787 35 ) ) -RRB- cord-335975-m6lkrehi 2787 36 . . . cord-335975-m6lkrehi 2788 1 In in IN cord-335975-m6lkrehi 2788 2 presence presence NN cord-335975-m6lkrehi 2788 3 of of IN cord-335975-m6lkrehi 2788 4 other other JJ cord-335975-m6lkrehi 2788 5 organ organ NN cord-335975-m6lkrehi 2788 6 failure failure NN cord-335975-m6lkrehi 2788 7 , , , cord-335975-m6lkrehi 2788 8 mortality mortality NN cord-335975-m6lkrehi 2788 9 rate rate NN cord-335975-m6lkrehi 2788 10 tends tend VBZ cord-335975-m6lkrehi 2788 11 to to TO cord-335975-m6lkrehi 2788 12 increase increase VB cord-335975-m6lkrehi 2788 13 . . . cord-335975-m6lkrehi 2789 1 Patients patient NNS cord-335975-m6lkrehi 2789 2 with with IN cord-335975-m6lkrehi 2789 3 median median JJ cord-335975-m6lkrehi 2789 4 PaO2 pao2 JJ cord-335975-m6lkrehi 2789 5 FiO fio NN cord-335975-m6lkrehi 2789 6 2 2 CD cord-335975-m6lkrehi 2789 7 ratio ratio NN cord-335975-m6lkrehi 2789 8 > > XX cord-335975-m6lkrehi 2789 9 196 196 CD cord-335975-m6lkrehi 2789 10 on on IN cord-335975-m6lkrehi 2789 11 first first JJ cord-335975-m6lkrehi 2789 12 blood blood NN cord-335975-m6lkrehi 2789 13 gas gas NN cord-335975-m6lkrehi 2789 14 had have VBD cord-335975-m6lkrehi 2789 15 a a DT cord-335975-m6lkrehi 2789 16 reduced reduced JJ cord-335975-m6lkrehi 2789 17 risk risk NN cord-335975-m6lkrehi 2789 18 of of IN cord-335975-m6lkrehi 2789 19 death death NN cord-335975-m6lkrehi 2789 20 ( ( -LRB- cord-335975-m6lkrehi 2789 21 OR OR NNP cord-335975-m6lkrehi 2789 22 0.4 0.4 CD cord-335975-m6lkrehi 2789 23 + + CC cord-335975-m6lkrehi 2790 1 CI CI NNP cord-335975-m6lkrehi 2790 2 95 95 CD cord-335975-m6lkrehi 2790 3 % % NN cord-335975-m6lkrehi 2790 4 [ [ -LRB- cord-335975-m6lkrehi 2790 5 0.1 0.1 CD cord-335975-m6lkrehi 2790 6 - - SYM cord-335975-m6lkrehi 2790 7 0.9 0.9 CD cord-335975-m6lkrehi 2790 8 ] ] -RRB- cord-335975-m6lkrehi 2791 1 , , , cord-335975-m6lkrehi 2791 2 p p NN cord-335975-m6lkrehi 2791 3 = = SYM cord-335975-m6lkrehi 2791 4 0.01 0.01 CD cord-335975-m6lkrehi 2791 5 ) ) -RRB- cord-335975-m6lkrehi 2791 6 . . . cord-335975-m6lkrehi 2792 1 Conclusion conclusion NN cord-335975-m6lkrehi 2792 2 : : : cord-335975-m6lkrehi 2793 1 This this DT cord-335975-m6lkrehi 2793 2 is be VBZ cord-335975-m6lkrehi 2793 3 the the DT cord-335975-m6lkrehi 2793 4 first first JJ cord-335975-m6lkrehi 2793 5 study study NN cord-335975-m6lkrehi 2793 6 to to TO cord-335975-m6lkrehi 2793 7 assess assess VB cord-335975-m6lkrehi 2793 8 mortality mortality NN cord-335975-m6lkrehi 2793 9 at at IN cord-335975-m6lkrehi 2793 10 6 6 CD cord-335975-m6lkrehi 2793 11 month month NN cord-335975-m6lkrehi 2793 12 of of IN cord-335975-m6lkrehi 2793 13 patients patient NNS cord-335975-m6lkrehi 2793 14 with with IN cord-335975-m6lkrehi 2793 15 severe severe JJ cord-335975-m6lkrehi 2793 16 COPD COPD NNP cord-335975-m6lkrehi 2793 17 requiring require VBG cord-335975-m6lkrehi 2793 18 LTOT LTOT NNP cord-335975-m6lkrehi 2793 19 admitted admit VBD cord-335975-m6lkrehi 2793 20 in in IN cord-335975-m6lkrehi 2793 21 ICU ICU NNP cord-335975-m6lkrehi 2793 22 . . . cord-335975-m6lkrehi 2794 1 Severity severity NN cord-335975-m6lkrehi 2794 2 of of IN cord-335975-m6lkrehi 2794 3 hypoxemia hypoxemia NN cord-335975-m6lkrehi 2794 4 and and CC cord-335975-m6lkrehi 2794 5 use use NN cord-335975-m6lkrehi 2794 6 of of IN cord-335975-m6lkrehi 2794 7 mechanical mechanical JJ cord-335975-m6lkrehi 2794 8 ventilation ventilation NN cord-335975-m6lkrehi 2794 9 are be VBP cord-335975-m6lkrehi 2794 10 two two CD cord-335975-m6lkrehi 2794 11 prognosis prognosis NN cord-335975-m6lkrehi 2794 12 factor factor NN cord-335975-m6lkrehi 2794 13 of of IN cord-335975-m6lkrehi 2794 14 mortality mortality NN cord-335975-m6lkrehi 2794 15 . . . cord-335975-m6lkrehi 2795 1 The the DT cord-335975-m6lkrehi 2795 2 addition addition NN cord-335975-m6lkrehi 2795 3 of of IN cord-335975-m6lkrehi 2795 4 another another DT cord-335975-m6lkrehi 2795 5 organ organ NN cord-335975-m6lkrehi 2795 6 failure failure NN cord-335975-m6lkrehi 2795 7 seems seem VBZ cord-335975-m6lkrehi 2795 8 to to TO cord-335975-m6lkrehi 2795 9 increase increase VB cord-335975-m6lkrehi 2795 10 the the DT cord-335975-m6lkrehi 2795 11 mortality mortality NN cord-335975-m6lkrehi 2795 12 rate rate NN cord-335975-m6lkrehi 2795 13 . . . cord-335975-m6lkrehi 2796 1 Severity severity NN cord-335975-m6lkrehi 2796 2 of of IN cord-335975-m6lkrehi 2796 3 the the DT cord-335975-m6lkrehi 2796 4 chronic chronic JJ cord-335975-m6lkrehi 2796 5 respiratory respiratory JJ cord-335975-m6lkrehi 2796 6 insufficiency insufficiency NN cord-335975-m6lkrehi 2796 7 less less RBR cord-335975-m6lkrehi 2796 8 influenced influence VBN cord-335975-m6lkrehi 2796 9 short short JJ cord-335975-m6lkrehi 2796 10 and and CC cord-335975-m6lkrehi 2796 11 long long JJ cord-335975-m6lkrehi 2796 12 term term NN cord-335975-m6lkrehi 2796 13 outcome outcome NN cord-335975-m6lkrehi 2796 14 . . . cord-335975-m6lkrehi 2797 1 This this DT cord-335975-m6lkrehi 2797 2 data datum NNS cord-335975-m6lkrehi 2797 3 have have VBP cord-335975-m6lkrehi 2797 4 to to TO cord-335975-m6lkrehi 2797 5 be be VB cord-335975-m6lkrehi 2797 6 included include VBN cord-335975-m6lkrehi 2797 7 in in IN cord-335975-m6lkrehi 2797 8 the the DT cord-335975-m6lkrehi 2797 9 global global JJ cord-335975-m6lkrehi 2797 10 decision decision NN cord-335975-m6lkrehi 2797 11 to to TO cord-335975-m6lkrehi 2797 12 admit admit VB cord-335975-m6lkrehi 2797 13 a a DT cord-335975-m6lkrehi 2797 14 COPD COPD NNP cord-335975-m6lkrehi 2797 15 patient patient NN cord-335975-m6lkrehi 2797 16 with with IN cord-335975-m6lkrehi 2797 17 LTOT LTOT NNP cord-335975-m6lkrehi 2797 18 in in IN cord-335975-m6lkrehi 2797 19 ICU ICU NNP cord-335975-m6lkrehi 2797 20 . . . cord-335975-m6lkrehi 2798 1 Introduction introduction NN cord-335975-m6lkrehi 2798 2 : : : cord-335975-m6lkrehi 2799 1 The the DT cord-335975-m6lkrehi 2799 2 remarkable remarkable JJ cord-335975-m6lkrehi 2799 3 progress progress NN cord-335975-m6lkrehi 2799 4 in in IN cord-335975-m6lkrehi 2799 5 the the DT cord-335975-m6lkrehi 2799 6 outpatient outpatient NN cord-335975-m6lkrehi 2799 7 care care NN cord-335975-m6lkrehi 2799 8 of of IN cord-335975-m6lkrehi 2799 9 the the DT cord-335975-m6lkrehi 2799 10 asthmatic asthmatic JJ cord-335975-m6lkrehi 2799 11 patient patient NN cord-335975-m6lkrehi 2799 12 ( ( -LRB- cord-335975-m6lkrehi 2799 13 development development NN cord-335975-m6lkrehi 2799 14 and and CC cord-335975-m6lkrehi 2799 15 access access NN cord-335975-m6lkrehi 2799 16 to to IN cord-335975-m6lkrehi 2799 17 inhaled inhale VBN cord-335975-m6lkrehi 2799 18 drugs drug NNS cord-335975-m6lkrehi 2799 19 ) ) -RRB- cord-335975-m6lkrehi 2799 20 has have VBZ cord-335975-m6lkrehi 2799 21 made make VBN cord-335975-m6lkrehi 2799 22 the the DT cord-335975-m6lkrehi 2799 23 admission admission NN cord-335975-m6lkrehi 2799 24 of of IN cord-335975-m6lkrehi 2799 25 these these DT cord-335975-m6lkrehi 2799 26 patients patient NNS cord-335975-m6lkrehi 2799 27 exceptional exceptional JJ cord-335975-m6lkrehi 2799 28 in in IN cord-335975-m6lkrehi 2799 29 the the DT cord-335975-m6lkrehi 2799 30 ICU ICU NNP cord-335975-m6lkrehi 2799 31 . . . cord-335975-m6lkrehi 2800 1 We -PRON- PRP cord-335975-m6lkrehi 2800 2 have have VBP cord-335975-m6lkrehi 2800 3 noticed notice VBN cord-335975-m6lkrehi 2800 4 a a DT cord-335975-m6lkrehi 2800 5 recent recent JJ cord-335975-m6lkrehi 2800 6 upsurge upsurge NN cord-335975-m6lkrehi 2800 7 in in IN cord-335975-m6lkrehi 2800 8 asthmatic asthmatic JJ cord-335975-m6lkrehi 2800 9 afmissions afmission NNS cord-335975-m6lkrehi 2800 10 in in IN cord-335975-m6lkrehi 2800 11 the the DT cord-335975-m6lkrehi 2800 12 ICU ICU NNP cord-335975-m6lkrehi 2800 13 , , , cord-335975-m6lkrehi 2800 14 and and CC cord-335975-m6lkrehi 2800 15 are be VBP cord-335975-m6lkrehi 2800 16 investigating investigate VBG cord-335975-m6lkrehi 2800 17 whether whether IN cord-335975-m6lkrehi 2800 18 this this DT cord-335975-m6lkrehi 2800 19 fact fact NN cord-335975-m6lkrehi 2800 20 was be VBD cord-335975-m6lkrehi 2800 21 related relate VBN cord-335975-m6lkrehi 2800 22 to to IN cord-335975-m6lkrehi 2800 23 modifiable modifiable JJ cord-335975-m6lkrehi 2800 24 factors factor NNS cord-335975-m6lkrehi 2800 25 ( ( -LRB- cord-335975-m6lkrehi 2800 26 access access NN cord-335975-m6lkrehi 2800 27 to to IN cord-335975-m6lkrehi 2800 28 adapted adapt VBN cord-335975-m6lkrehi 2800 29 drugs drug NNS cord-335975-m6lkrehi 2800 30 ) ) -RRB- cord-335975-m6lkrehi 2800 31 or or CC cord-335975-m6lkrehi 2800 32 an an DT cord-335975-m6lkrehi 2800 33 increase increase NN cord-335975-m6lkrehi 2800 34 in in IN cord-335975-m6lkrehi 2800 35 the the DT cord-335975-m6lkrehi 2800 36 severity severity NN cord-335975-m6lkrehi 2800 37 of of IN cord-335975-m6lkrehi 2800 38 the the DT cord-335975-m6lkrehi 2800 39 disease disease NN cord-335975-m6lkrehi 2800 40 . . . cord-335975-m6lkrehi 2801 1 Patients patient NNS cord-335975-m6lkrehi 2801 2 and and CC cord-335975-m6lkrehi 2801 3 methods method NNS cord-335975-m6lkrehi 2801 4 : : : cord-335975-m6lkrehi 2801 5 Retrospective retrospective JJ cord-335975-m6lkrehi 2801 6 , , , cord-335975-m6lkrehi 2801 7 observational observational JJ cord-335975-m6lkrehi 2801 8 , , , cord-335975-m6lkrehi 2801 9 three three CD cord-335975-m6lkrehi 2801 10 - - HYPH cord-335975-m6lkrehi 2801 11 center center NN cord-335975-m6lkrehi 2801 12 study study NN cord-335975-m6lkrehi 2801 13 conducted conduct VBN cord-335975-m6lkrehi 2801 14 in in IN cord-335975-m6lkrehi 2801 15 three three CD cord-335975-m6lkrehi 2801 16 Tunisian tunisian JJ cord-335975-m6lkrehi 2801 17 medical medical JJ cord-335975-m6lkrehi 2801 18 ICU ICU NNP cord-335975-m6lkrehi 2801 19 from from IN cord-335975-m6lkrehi 2801 20 January January NNP cord-335975-m6lkrehi 2801 21 2016 2016 CD cord-335975-m6lkrehi 2801 22 to to IN cord-335975-m6lkrehi 2801 23 July July NNP cord-335975-m6lkrehi 2801 24 , , , cord-335975-m6lkrehi 2801 25 2017 2017 CD cord-335975-m6lkrehi 2801 26 . . . cord-335975-m6lkrehi 2802 1 Were be VBD cord-335975-m6lkrehi 2802 2 included include VBN cord-335975-m6lkrehi 2802 3 all all DT cord-335975-m6lkrehi 2802 4 consecutive consecutive JJ cord-335975-m6lkrehi 2802 5 patients patient NNS cord-335975-m6lkrehi 2802 6 admitted admit VBN cord-335975-m6lkrehi 2802 7 for for IN cord-335975-m6lkrehi 2802 8 severe severe JJ cord-335975-m6lkrehi 2802 9 acute acute JJ cord-335975-m6lkrehi 2802 10 asthma asthma NN cord-335975-m6lkrehi 2802 11 in in IN cord-335975-m6lkrehi 2802 12 three three CD cord-335975-m6lkrehi 2802 13 ICUs icu NNS cord-335975-m6lkrehi 2802 14 . . . cord-335975-m6lkrehi 2803 1 Were be VBD cord-335975-m6lkrehi 2803 2 assessed assess VBN cord-335975-m6lkrehi 2803 3 - - HYPH cord-335975-m6lkrehi 2803 4 patient patient NN cord-335975-m6lkrehi 2803 5 's 's POS cord-335975-m6lkrehi 2803 6 demographic demographic JJ cord-335975-m6lkrehi 2803 7 characteristics characteristic NNS cord-335975-m6lkrehi 2803 8 , , , cord-335975-m6lkrehi 2803 9 asthma asthma NN cord-335975-m6lkrehi 2803 10 severity severity NN cord-335975-m6lkrehi 2803 11 and and CC cord-335975-m6lkrehi 2803 12 its -PRON- PRP$ cord-335975-m6lkrehi 2803 13 actual actual JJ cord-335975-m6lkrehi 2803 14 control control NN cord-335975-m6lkrehi 2803 15 based base VBN cord-335975-m6lkrehi 2803 16 on on IN cord-335975-m6lkrehi 2803 17 Global Global NNP cord-335975-m6lkrehi 2803 18 Initiative Initiative NNP cord-335975-m6lkrehi 2803 19 for for IN cord-335975-m6lkrehi 2803 20 Asthma Asthma NNP cord-335975-m6lkrehi 2803 21 classification classification NN cord-335975-m6lkrehi 2804 1 ( ( -LRB- cord-335975-m6lkrehi 2804 2 GINA GINA NNP cord-335975-m6lkrehi 2804 3 ) ) -RRB- cord-335975-m6lkrehi 2804 4 2016 2016 CD cord-335975-m6lkrehi 2804 5 , , , cord-335975-m6lkrehi 2804 6 clinical clinical JJ cord-335975-m6lkrehi 2804 7 characteristics characteristic NNS cord-335975-m6lkrehi 2804 8 of of IN cord-335975-m6lkrehi 2804 9 the the DT cord-335975-m6lkrehi 2804 10 acute acute JJ cord-335975-m6lkrehi 2804 11 episode episode NN cord-335975-m6lkrehi 2804 12 , , , cord-335975-m6lkrehi 2804 13 length length NN cord-335975-m6lkrehi 2804 14 of of IN cord-335975-m6lkrehi 2804 15 ICU ICU NNP cord-335975-m6lkrehi 2804 16 stay stay NN cord-335975-m6lkrehi 2804 17 , , , cord-335975-m6lkrehi 2804 18 ventilatory ventilatory JJ cord-335975-m6lkrehi 2804 19 free free JJ cord-335975-m6lkrehi 2804 20 days day NNS cord-335975-m6lkrehi 2804 21 and and CC cord-335975-m6lkrehi 2804 22 mortality mortality NN cord-335975-m6lkrehi 2804 23 . . . cord-335975-m6lkrehi 2805 1 Results result NNS cord-335975-m6lkrehi 2805 2 : : : cord-335975-m6lkrehi 2806 1 Out out IN cord-335975-m6lkrehi 2806 2 of of IN cord-335975-m6lkrehi 2806 3 the1142 the1142 NN cord-335975-m6lkrehi 2806 4 patients patient NNS cord-335975-m6lkrehi 2806 5 admitted admit VBN cord-335975-m6lkrehi 2806 6 within within IN cord-335975-m6lkrehi 2806 7 the the DT cord-335975-m6lkrehi 2806 8 study study NN cord-335975-m6lkrehi 2806 9 period period NN cord-335975-m6lkrehi 2806 10 , , , cord-335975-m6lkrehi 2806 11 34 34 CD cord-335975-m6lkrehi 2806 12 ( ( -LRB- cord-335975-m6lkrehi 2806 13 3 3 CD cord-335975-m6lkrehi 2806 14 % % NN cord-335975-m6lkrehi 2806 15 ) ) -RRB- cord-335975-m6lkrehi 2806 16 had have VBD cord-335975-m6lkrehi 2806 17 severe severe JJ cord-335975-m6lkrehi 2806 18 acute acute JJ cord-335975-m6lkrehi 2806 19 asthma asthma NN cord-335975-m6lkrehi 2806 20 . . . cord-335975-m6lkrehi 2807 1 The the DT cord-335975-m6lkrehi 2807 2 mean mean JJ cord-335975-m6lkrehi 2807 3 age age NN cord-335975-m6lkrehi 2807 4 was be VBD cord-335975-m6lkrehi 2807 5 37 37 CD cord-335975-m6lkrehi 2807 6 years year NNS cord-335975-m6lkrehi 2807 7 ( ( -LRB- cord-335975-m6lkrehi 2807 8 IQR32 IQR32 NNP cord-335975-m6lkrehi 2807 9 - - HYPH cord-335975-m6lkrehi 2807 10 50.5 50.5 CD cord-335975-m6lkrehi 2807 11 ) ) -RRB- cord-335975-m6lkrehi 2807 12 . . . cord-335975-m6lkrehi 2808 1 Sex sex NN cord-335975-m6lkrehi 2808 2 ratio ratio NN cord-335975-m6lkrehi 2808 3 was be VBD cord-335975-m6lkrehi 2808 4 1 1 CD cord-335975-m6lkrehi 2808 5 . . . cord-335975-m6lkrehi 2809 1 Asthma asthma NN cord-335975-m6lkrehi 2809 2 was be VBD cord-335975-m6lkrehi 2809 3 allergic allergic JJ cord-335975-m6lkrehi 2809 4 in in IN cord-335975-m6lkrehi 2809 5 84 84 CD cord-335975-m6lkrehi 2809 6 % % NN cord-335975-m6lkrehi 2809 7 with with IN cord-335975-m6lkrehi 2809 8 an an DT cord-335975-m6lkrehi 2809 9 average average JJ cord-335975-m6lkrehi 2809 10 ancienty ancienty NN cord-335975-m6lkrehi 2809 11 of of IN cord-335975-m6lkrehi 2809 12 14.7 14.7 CD cord-335975-m6lkrehi 2809 13 years year NNS cord-335975-m6lkrehi 2809 14 . . . cord-335975-m6lkrehi 2810 1 Over over IN cord-335975-m6lkrehi 2810 2 all all DT cord-335975-m6lkrehi 2810 3 asthma asthma NN cord-335975-m6lkrehi 2810 4 was be VBD cord-335975-m6lkrehi 2810 5 not not RB cord-335975-m6lkrehi 2810 6 very very RB cord-335975-m6lkrehi 2810 7 severe severe JJ cord-335975-m6lkrehi 2810 8 with with IN cord-335975-m6lkrehi 2810 9 no no DT cord-335975-m6lkrehi 2810 10 prior prior JJ cord-335975-m6lkrehi 2810 11 ICU ICU NNP cord-335975-m6lkrehi 2810 12 admission admission NN cord-335975-m6lkrehi 2810 13 for for IN cord-335975-m6lkrehi 2810 14 acute acute JJ cord-335975-m6lkrehi 2810 15 severe severe JJ cord-335975-m6lkrehi 2810 16 asthma asthma NN cord-335975-m6lkrehi 2810 17 38.2 38.2 CD cord-335975-m6lkrehi 2810 18 % % NN cord-335975-m6lkrehi 2810 19 were be VBD cord-335975-m6lkrehi 2810 20 mechanically mechanically RB cord-335975-m6lkrehi 2810 21 ventilated ventilate VBN cord-335975-m6lkrehi 2810 22 at at IN cord-335975-m6lkrehi 2810 23 least least RBS cord-335975-m6lkrehi 2810 24 one one CD cord-335975-m6lkrehi 2810 25 time time NN cord-335975-m6lkrehi 2810 26 . . . cord-335975-m6lkrehi 2811 1 Were be VBD cord-335975-m6lkrehi 2811 2 classified classify VBN cord-335975-m6lkrehi 2811 3 severe severe JJ cord-335975-m6lkrehi 2811 4 and and CC cord-335975-m6lkrehi 2811 5 moderate moderate JJ cord-335975-m6lkrehi 2811 6 persistant persistant JJ cord-335975-m6lkrehi 2811 7 asthma asthma NN cord-335975-m6lkrehi 2811 8 respectively respectively RB cord-335975-m6lkrehi 2811 9 in in IN cord-335975-m6lkrehi 2811 10 42.9(% 42.9(% CD cord-335975-m6lkrehi 2811 11 ) ) -RRB- cord-335975-m6lkrehi 2811 12 and and CC cord-335975-m6lkrehi 2811 13 19(% 19(% NNP cord-335975-m6lkrehi 2811 14 ) ) -RRB- cord-335975-m6lkrehi 2811 15 . . . cord-335975-m6lkrehi 2812 1 57.1 57.1 CD cord-335975-m6lkrehi 2812 2 % % NN cord-335975-m6lkrehi 2812 3 were be VBD cord-335975-m6lkrehi 2812 4 consideredpoorly consideredpoorly RB cord-335975-m6lkrehi 2812 5 controlled control VBN cord-335975-m6lkrehi 2812 6 . . . cord-335975-m6lkrehi 2813 1 Low low JJ cord-335975-m6lkrehi 2813 2 educational educational JJ cord-335975-m6lkrehi 2813 3 level level NN cord-335975-m6lkrehi 2813 4 and and CC cord-335975-m6lkrehi 2813 5 socio socio JJ cord-335975-m6lkrehi 2813 6 - - HYPH cord-335975-m6lkrehi 2813 7 economic economic JJ cord-335975-m6lkrehi 2813 8 status status NN cord-335975-m6lkrehi 2813 9 are be VBP cord-335975-m6lkrehi 2813 10 the the DT cord-335975-m6lkrehi 2813 11 main main JJ cord-335975-m6lkrehi 2813 12 determinants determinant NNS cord-335975-m6lkrehi 2813 13 of of IN cord-335975-m6lkrehi 2813 14 poor poor JJ cord-335975-m6lkrehi 2813 15 control-20 control-20 CD cord-335975-m6lkrehi 2813 16 % % NN cord-335975-m6lkrehi 2813 17 of of IN cord-335975-m6lkrehi 2813 18 analyzed analyze VBN cord-335975-m6lkrehi 2813 19 patients patient NNS cord-335975-m6lkrehi 2813 20 did do VBD cord-335975-m6lkrehi 2813 21 n't not RB cord-335975-m6lkrehi 2813 22 have have VB cord-335975-m6lkrehi 2813 23 a a DT cord-335975-m6lkrehi 2813 24 social social JJ cord-335975-m6lkrehi 2813 25 care care NN cord-335975-m6lkrehi 2813 26 , , , cord-335975-m6lkrehi 2813 27 and and CC cord-335975-m6lkrehi 2813 28 thus thus RB cord-335975-m6lkrehi 2813 29 no no DT cord-335975-m6lkrehi 2813 30 accesse accesse NN cord-335975-m6lkrehi 2813 31 to to TO cord-335975-m6lkrehi 2813 32 prescribed prescribed VB cord-335975-m6lkrehi 2813 33 anti anti NNS cord-335975-m6lkrehi 2813 34 - - NNS cord-335975-m6lkrehi 2813 35 asthmatics asthmatic NNS cord-335975-m6lkrehi 2814 1 + + SYM cord-335975-m6lkrehi 2814 2 40 40 CD cord-335975-m6lkrehi 2814 3 % % NN cord-335975-m6lkrehi 2814 4 did do VBD cord-335975-m6lkrehi 2814 5 n't not RB cord-335975-m6lkrehi 2814 6 have have VB cord-335975-m6lkrehi 2814 7 a a DT cord-335975-m6lkrehi 2814 8 regular regular JJ cord-335975-m6lkrehi 2814 9 follow follow NN cord-335975-m6lkrehi 2814 10 up up RB cord-335975-m6lkrehi 2814 11 and and CC cord-335975-m6lkrehi 2814 12 23.5 23.5 CD cord-335975-m6lkrehi 2814 13 % % NN cord-335975-m6lkrehi 2814 14 were be VBD cord-335975-m6lkrehi 2814 15 jobless jobless JJ cord-335975-m6lkrehi 2814 16 . . . cord-335975-m6lkrehi 2815 1 When when WRB cord-335975-m6lkrehi 2815 2 admitted admit VBN cord-335975-m6lkrehi 2815 3 to to IN cord-335975-m6lkrehi 2815 4 the the DT cord-335975-m6lkrehi 2815 5 ICU-23 ICU-23 NNP cord-335975-m6lkrehi 2815 6 patients patient NNS cord-335975-m6lkrehi 2815 7 ( ( -LRB- cord-335975-m6lkrehi 2815 8 67.6 67.6 CD cord-335975-m6lkrehi 2815 9 % % NN cord-335975-m6lkrehi 2815 10 ) ) -RRB- cord-335975-m6lkrehi 2815 11 needed need VBD cord-335975-m6lkrehi 2815 12 invasive invasive JJ cord-335975-m6lkrehi 2815 13 mechanical mechanical JJ cord-335975-m6lkrehi 2815 14 ventilation ventilation NN cord-335975-m6lkrehi 2815 15 , , , cord-335975-m6lkrehi 2815 16 one one CD cord-335975-m6lkrehi 2815 17 patient patient NN cord-335975-m6lkrehi 2815 18 received receive VBD cord-335975-m6lkrehi 2815 19 NIV NIV NNP cord-335975-m6lkrehi 2815 20 . . . cord-335975-m6lkrehi 2816 1 The the DT cord-335975-m6lkrehi 2816 2 mean mean JJ cord-335975-m6lkrehi 2816 3 length length NN cord-335975-m6lkrehi 2816 4 of of IN cord-335975-m6lkrehi 2816 5 stay stay NN cord-335975-m6lkrehi 2816 6 was be VBD cord-335975-m6lkrehi 2816 7 8 8 CD cord-335975-m6lkrehi 2816 8 days day NNS cord-335975-m6lkrehi 2816 9 ( ( -LRB- cord-335975-m6lkrehi 2816 10 IQR IQR NNP cord-335975-m6lkrehi 2816 11 3.5 3.5 CD cord-335975-m6lkrehi 2816 12 - - HYPH cord-335975-m6lkrehi 2816 13 12.5 12.5 CD cord-335975-m6lkrehi 2816 14 ) ) -RRB- cord-335975-m6lkrehi 2816 15 . . . cord-335975-m6lkrehi 2817 1 Levels level NNS cord-335975-m6lkrehi 2817 2 of of IN cord-335975-m6lkrehi 2817 3 auto auto NN cord-335975-m6lkrehi 2817 4 PEEP peep NN cord-335975-m6lkrehi 2817 5 and and CC cord-335975-m6lkrehi 2817 6 PIC pic NN cord-335975-m6lkrehi 2817 7 pressure pressure NN cord-335975-m6lkrehi 2817 8 at at IN cord-335975-m6lkrehi 2817 9 ICU ICU NNP cord-335975-m6lkrehi 2817 10 admission admission NN cord-335975-m6lkrehi 2817 11 were be VBD cord-335975-m6lkrehi 2817 12 respectively respectively RB cord-335975-m6lkrehi 2817 13 6 6 CD cord-335975-m6lkrehi 2818 1 ( ( -LRB- cord-335975-m6lkrehi 2818 2 IQR IQR NNP cord-335975-m6lkrehi 2818 3 1 1 CD cord-335975-m6lkrehi 2818 4 - - SYM cord-335975-m6lkrehi 2818 5 12 12 CD cord-335975-m6lkrehi 2818 6 ) ) -RRB- cord-335975-m6lkrehi 2818 7 and47.5 and47.5 VBN cord-335975-m6lkrehi 2818 8 ( ( -LRB- cord-335975-m6lkrehi 2818 9 IQR IQR NNP cord-335975-m6lkrehi 2818 10 37 37 CD cord-335975-m6lkrehi 2818 11 , , , cord-335975-m6lkrehi 2818 12 25 25 CD cord-335975-m6lkrehi 2818 13 - - SYM cord-335975-m6lkrehi 2818 14 58.5 58.5 CD cord-335975-m6lkrehi 2818 15 ) ) -RRB- cord-335975-m6lkrehi 2818 16 cm cm NN cord-335975-m6lkrehi 2818 17 H H NNP cord-335975-m6lkrehi 2818 18 2 2 CD cord-335975-m6lkrehi 2818 19 O. O. NNP cord-335975-m6lkrehi 2818 20 Mortality Mortality NNP cord-335975-m6lkrehi 2818 21 rate rate NN cord-335975-m6lkrehi 2818 22 was be VBD cord-335975-m6lkrehi 2818 23 3 3 CD cord-335975-m6lkrehi 2818 24 % % NN cord-335975-m6lkrehi 2818 25 . . . cord-335975-m6lkrehi 2819 1 This this DT cord-335975-m6lkrehi 2819 2 study study NN cord-335975-m6lkrehi 2819 3 suggests suggest VBZ cord-335975-m6lkrehi 2819 4 that that IN cord-335975-m6lkrehi 2819 5 Low low JJ cord-335975-m6lkrehi 2819 6 educational educational JJ cord-335975-m6lkrehi 2819 7 level level NN cord-335975-m6lkrehi 2819 8 and and CC cord-335975-m6lkrehi 2819 9 socioeconomic socioeconomic JJ cord-335975-m6lkrehi 2819 10 status status NN cord-335975-m6lkrehi 2819 11 ( ( -LRB- cord-335975-m6lkrehi 2819 12 especially especially RB cord-335975-m6lkrehi 2819 13 the the DT cord-335975-m6lkrehi 2819 14 lack lack NN cord-335975-m6lkrehi 2819 15 of of IN cord-335975-m6lkrehi 2819 16 social social JJ cord-335975-m6lkrehi 2819 17 care care NN cord-335975-m6lkrehi 2819 18 and and CC cord-335975-m6lkrehi 2819 19 joblessness joblessness NN cord-335975-m6lkrehi 2819 20 ) ) -RRB- cord-335975-m6lkrehi 2819 21 are be VBP cord-335975-m6lkrehi 2819 22 the the DT cord-335975-m6lkrehi 2819 23 main main JJ cord-335975-m6lkrehi 2819 24 determinants determinant NNS cord-335975-m6lkrehi 2819 25 of of IN cord-335975-m6lkrehi 2819 26 poor poor JJ cord-335975-m6lkrehi 2819 27 control control NN cord-335975-m6lkrehi 2819 28 of of IN cord-335975-m6lkrehi 2819 29 asthma asthma NN cord-335975-m6lkrehi 2819 30 and and CC cord-335975-m6lkrehi 2819 31 may may MD cord-335975-m6lkrehi 2819 32 lead lead VB cord-335975-m6lkrehi 2819 33 to to IN cord-335975-m6lkrehi 2819 34 the the DT cord-335975-m6lkrehi 2819 35 increase increase NN cord-335975-m6lkrehi 2819 36 of of IN cord-335975-m6lkrehi 2819 37 rate rate NN cord-335975-m6lkrehi 2819 38 of of IN cord-335975-m6lkrehi 2819 39 ICU ICU NNP cord-335975-m6lkrehi 2819 40 admission admission NN cord-335975-m6lkrehi 2819 41 for for IN cord-335975-m6lkrehi 2819 42 severe severe JJ cord-335975-m6lkrehi 2819 43 acute acute JJ cord-335975-m6lkrehi 2819 44 asthma asthma NN cord-335975-m6lkrehi 2819 45 requiring require VBG cord-335975-m6lkrehi 2819 46 mechanical mechanical JJ cord-335975-m6lkrehi 2819 47 ventilation ventilation NN cord-335975-m6lkrehi 2819 48 . . . cord-335975-m6lkrehi 2820 1 Introduction introduction NN cord-335975-m6lkrehi 2820 2 : : : cord-335975-m6lkrehi 2821 1 In in IN cord-335975-m6lkrehi 2821 2 emergency emergency NN cord-335975-m6lkrehi 2821 3 medicine medicine NN cord-335975-m6lkrehi 2821 4 , , , cord-335975-m6lkrehi 2821 5 the the DT cord-335975-m6lkrehi 2821 6 Boussignac Boussignac NNP cord-335975-m6lkrehi 2821 7 system system NN cord-335975-m6lkrehi 2821 8 ( ( -LRB- cord-335975-m6lkrehi 2821 9 BS BS NNP cord-335975-m6lkrehi 2821 10 ) ) -RRB- cord-335975-m6lkrehi 2821 11 is be VBZ cord-335975-m6lkrehi 2821 12 sometimes sometimes RB cord-335975-m6lkrehi 2821 13 used use VBN cord-335975-m6lkrehi 2821 14 to to TO cord-335975-m6lkrehi 2821 15 administer administer VB cord-335975-m6lkrehi 2821 16 oxygen oxygen NN cord-335975-m6lkrehi 2821 17 and and CC cord-335975-m6lkrehi 2821 18 continuous continuous JJ cord-335975-m6lkrehi 2821 19 positive positive JJ cord-335975-m6lkrehi 2821 20 airway airway NN cord-335975-m6lkrehi 2821 21 pressure pressure NN cord-335975-m6lkrehi 2821 22 ( ( -LRB- cord-335975-m6lkrehi 2821 23 cpap cpap NNP cord-335975-m6lkrehi 2821 24 ) ) -RRB- cord-335975-m6lkrehi 2821 25 . . . cord-335975-m6lkrehi 2822 1 In in IN cord-335975-m6lkrehi 2822 2 this this DT cord-335975-m6lkrehi 2822 3 case case NN cord-335975-m6lkrehi 2822 4 , , , cord-335975-m6lkrehi 2822 5 FiO fio NN cord-335975-m6lkrehi 2822 6 2 2 CD cord-335975-m6lkrehi 2822 7 value value NN cord-335975-m6lkrehi 2822 8 depends depend VBZ cord-335975-m6lkrehi 2822 9 on on IN cord-335975-m6lkrehi 2822 10 the the DT cord-335975-m6lkrehi 2822 11 ratio ratio NN cord-335975-m6lkrehi 2822 12 between between IN cord-335975-m6lkrehi 2822 13 O o NN cord-335975-m6lkrehi 2822 14 2 2 CD cord-335975-m6lkrehi 2822 15 flow flow NN cord-335975-m6lkrehi 2822 16 and and CC cord-335975-m6lkrehi 2822 17 inspiratory inspiratory JJ cord-335975-m6lkrehi 2822 18 flow flow NN cord-335975-m6lkrehi 2822 19 ( ( -LRB- cord-335975-m6lkrehi 2822 20 IF if NN cord-335975-m6lkrehi 2822 21 ) ) -RRB- cord-335975-m6lkrehi 2822 22 . . . cord-335975-m6lkrehi 2823 1 In in IN cord-335975-m6lkrehi 2823 2 some some DT cord-335975-m6lkrehi 2823 3 cases case NNS cord-335975-m6lkrehi 2823 4 , , , cord-335975-m6lkrehi 2823 5 the the DT cord-335975-m6lkrehi 2823 6 FiO FiO NNP cord-335975-m6lkrehi 2823 7 2 2 CD cord-335975-m6lkrehi 2823 8 decreases decrease VBZ cord-335975-m6lkrehi 2823 9 due due IN cord-335975-m6lkrehi 2823 10 to to IN cord-335975-m6lkrehi 2823 11 the the DT cord-335975-m6lkrehi 2823 12 IF IF NNP cord-335975-m6lkrehi 2823 13 increase increase NN cord-335975-m6lkrehi 2823 14 . . . cord-335975-m6lkrehi 2824 1 The the DT cord-335975-m6lkrehi 2824 2 aim aim NN cord-335975-m6lkrehi 2824 3 of of IN cord-335975-m6lkrehi 2824 4 this this DT cord-335975-m6lkrehi 2824 5 study study NN cord-335975-m6lkrehi 2824 6 was be VBD cord-335975-m6lkrehi 2824 7 to to TO cord-335975-m6lkrehi 2824 8 test test VB cord-335975-m6lkrehi 2824 9 a a DT cord-335975-m6lkrehi 2824 10 modified modify VBN cord-335975-m6lkrehi 2824 11 Boussignac Boussignac NNP cord-335975-m6lkrehi 2824 12 system system NN cord-335975-m6lkrehi 2824 13 in in IN cord-335975-m6lkrehi 2824 14 order order NN cord-335975-m6lkrehi 2824 15 to to TO cord-335975-m6lkrehi 2824 16 limit limit VB cord-335975-m6lkrehi 2824 17 the the DT cord-335975-m6lkrehi 2824 18 FiO FiO NNS cord-335975-m6lkrehi 2824 19 2 2 CD cord-335975-m6lkrehi 2824 20 decreases decrease NNS cord-335975-m6lkrehi 2824 21 during during IN cord-335975-m6lkrehi 2824 22 inspiratory inspiratory JJ cord-335975-m6lkrehi 2824 23 flow flow NN cord-335975-m6lkrehi 2824 24 rate rate NN cord-335975-m6lkrehi 2824 25 increases increase NNS cord-335975-m6lkrehi 2824 26 . . . cord-335975-m6lkrehi 2825 1 The the DT cord-335975-m6lkrehi 2825 2 study study NN cord-335975-m6lkrehi 2825 3 was be VBD cord-335975-m6lkrehi 2825 4 conducted conduct VBN cord-335975-m6lkrehi 2825 5 on on IN cord-335975-m6lkrehi 2825 6 bench bench NN cord-335975-m6lkrehi 2825 7 with with IN cord-335975-m6lkrehi 2825 8 BS BS NNP cord-335975-m6lkrehi 2825 9 connected connect VBN cord-335975-m6lkrehi 2825 10 to to IN cord-335975-m6lkrehi 2825 11 a a DT cord-335975-m6lkrehi 2825 12 two two CD cord-335975-m6lkrehi 2825 13 compartment compartment NN cord-335975-m6lkrehi 2825 14 adult adult NN cord-335975-m6lkrehi 2825 15 lung lung NN cord-335975-m6lkrehi 2825 16 model model NN cord-335975-m6lkrehi 2826 1 ( ( -LRB- cord-335975-m6lkrehi 2826 2 Dual Dual NNP cord-335975-m6lkrehi 2826 3 Test Test NNP cord-335975-m6lkrehi 2826 4 Lung Lung NNP cord-335975-m6lkrehi 2826 5 ® ® . cord-335975-m6lkrehi 2826 6 ) ) -RRB- cord-335975-m6lkrehi 2826 7 ( ( -LRB- cord-335975-m6lkrehi 2826 8 DTL DTL NNP cord-335975-m6lkrehi 2826 9 ) ) -RRB- cord-335975-m6lkrehi 2826 10 controlled control VBN cord-335975-m6lkrehi 2826 11 by by IN cord-335975-m6lkrehi 2826 12 a a DT cord-335975-m6lkrehi 2826 13 Maquet Maquet NNP cord-335975-m6lkrehi 2826 14 Servo Servo NNP cord-335975-m6lkrehi 2826 15 I -PRON- PRP cord-335975-m6lkrehi 2826 16 ® ® VBP cord-335975-m6lkrehi 2826 17 ventilator ventilator NN cord-335975-m6lkrehi 2826 18 . . . cord-335975-m6lkrehi 2827 1 Three three CD cord-335975-m6lkrehi 2827 2 minute minute NN cord-335975-m6lkrehi 2827 3 ventilation ventilation NN cord-335975-m6lkrehi 2828 1 ( ( -LRB- cord-335975-m6lkrehi 2828 2 MV-7.5 MV-7.5 NNP cord-335975-m6lkrehi 2828 3 15 15 CD cord-335975-m6lkrehi 2828 4 22.5 22.5 CD cord-335975-m6lkrehi 2828 5 L l NN cord-335975-m6lkrehi 2828 6 min min NN cord-335975-m6lkrehi 2828 7 ) ) -RRB- cord-335975-m6lkrehi 2828 8 with with IN cord-335975-m6lkrehi 2828 9 Ti Ti NNP cord-335975-m6lkrehi 2828 10 Ttot Ttot NNP cord-335975-m6lkrehi 2828 11 = = SYM cord-335975-m6lkrehi 2828 12 0.33 0.33 CD cord-335975-m6lkrehi 2828 13 were be VBD cord-335975-m6lkrehi 2828 14 investigated investigate VBN cord-335975-m6lkrehi 2828 15 . . . cord-335975-m6lkrehi 2829 1 FiO FiO NNP cord-335975-m6lkrehi 2829 2 2 2 CD cord-335975-m6lkrehi 2829 3 and and CC cord-335975-m6lkrehi 2829 4 MV MV NNP cord-335975-m6lkrehi 2829 5 measurements measurement NNS cord-335975-m6lkrehi 2829 6 were be VBD cord-335975-m6lkrehi 2829 7 made make VBN cord-335975-m6lkrehi 2829 8 using use VBG cord-335975-m6lkrehi 2829 9 an an DT cord-335975-m6lkrehi 2829 10 iWorx iWorx NNP cord-335975-m6lkrehi 2829 11 ® ® NN cord-335975-m6lkrehi 2829 12 GA207 ga207 CD cord-335975-m6lkrehi 2829 13 gas gas NN cord-335975-m6lkrehi 2829 14 analyzer analyzer NN cord-335975-m6lkrehi 2829 15 . . . cord-335975-m6lkrehi 2830 1 With with IN cord-335975-m6lkrehi 2830 2 a a DT cord-335975-m6lkrehi 2830 3 BS BS NNP cord-335975-m6lkrehi 2830 4 , , , cord-335975-m6lkrehi 2830 5 two two CD cord-335975-m6lkrehi 2830 6 Peep Peep NNP cord-335975-m6lkrehi 2830 7 were be VBD cord-335975-m6lkrehi 2830 8 analyzed-3 analyzed-3 NNP cord-335975-m6lkrehi 2830 9 and and CC cord-335975-m6lkrehi 2830 10 10 10 CD cord-335975-m6lkrehi 2830 11 cm cm NNS cord-335975-m6lkrehi 2831 1 H2O. H2O. NNP cord-335975-m6lkrehi 2832 1 The the DT cord-335975-m6lkrehi 2832 2 BS BS NNP cord-335975-m6lkrehi 2832 3 was be VBD cord-335975-m6lkrehi 2832 4 supplied supply VBN cord-335975-m6lkrehi 2832 5 by by IN cord-335975-m6lkrehi 2832 6 an an DT cord-335975-m6lkrehi 2832 7 O o NN cord-335975-m6lkrehi 2832 8 2 2 CD cord-335975-m6lkrehi 2832 9 flow flow NN cord-335975-m6lkrehi 2832 10 . . . cord-335975-m6lkrehi 2833 1 In in IN cord-335975-m6lkrehi 2833 2 order order NN cord-335975-m6lkrehi 2833 3 to to TO cord-335975-m6lkrehi 2833 4 increase increase VB cord-335975-m6lkrehi 2833 5 the the DT cord-335975-m6lkrehi 2833 6 FiO FiO NNS cord-335975-m6lkrehi 2833 7 2 2 CD cord-335975-m6lkrehi 2833 8 , , , cord-335975-m6lkrehi 2833 9 we -PRON- PRP cord-335975-m6lkrehi 2833 10 have have VBP cord-335975-m6lkrehi 2833 11 evaluated evaluate VBN cord-335975-m6lkrehi 2833 12 the the DT cord-335975-m6lkrehi 2833 13 addition addition NN cord-335975-m6lkrehi 2833 14 of of IN cord-335975-m6lkrehi 2833 15 a a DT cord-335975-m6lkrehi 2833 16 T T NNP cord-335975-m6lkrehi 2833 17 piece piece NN cord-335975-m6lkrehi 2833 18 connected connect VBN cord-335975-m6lkrehi 2833 19 to to IN cord-335975-m6lkrehi 2833 20 a a DT cord-335975-m6lkrehi 2833 21 nebulizer nebulizer NN cord-335975-m6lkrehi 2833 22 at at IN cord-335975-m6lkrehi 2833 23 the the DT cord-335975-m6lkrehi 2833 24 air air NN cord-335975-m6lkrehi 2833 25 - - HYPH cord-335975-m6lkrehi 2833 26 room room NN cord-335975-m6lkrehi 2833 27 admission admission NN cord-335975-m6lkrehi 2833 28 of of IN cord-335975-m6lkrehi 2833 29 a a DT cord-335975-m6lkrehi 2833 30 BS BS NNP cord-335975-m6lkrehi 2833 31 . . . cord-335975-m6lkrehi 2834 1 The the DT cord-335975-m6lkrehi 2834 2 aerosol aerosol NN cord-335975-m6lkrehi 2834 3 was be VBD cord-335975-m6lkrehi 2834 4 supplied supply VBN cord-335975-m6lkrehi 2834 5 by by IN cord-335975-m6lkrehi 2834 6 an an DT cord-335975-m6lkrehi 2834 7 O o NN cord-335975-m6lkrehi 2834 8 2 2 CD cord-335975-m6lkrehi 2834 9 flow flow NN cord-335975-m6lkrehi 2834 10 of of IN cord-335975-m6lkrehi 2834 11 9 9 CD cord-335975-m6lkrehi 2834 12 L l NN cord-335975-m6lkrehi 2834 13 min min NN cord-335975-m6lkrehi 2834 14 . . . cord-335975-m6lkrehi 2835 1 The the DT cord-335975-m6lkrehi 2835 2 O o NN cord-335975-m6lkrehi 2835 3 2 2 CD cord-335975-m6lkrehi 2835 4 flow flow NN cord-335975-m6lkrehi 2835 5 was be VBD cord-335975-m6lkrehi 2835 6 analyzed analyze VBN cord-335975-m6lkrehi 2835 7 in in IN cord-335975-m6lkrehi 2835 8 continuous continuous JJ cord-335975-m6lkrehi 2835 9 with with IN cord-335975-m6lkrehi 2835 10 a a DT cord-335975-m6lkrehi 2835 11 calibrated calibrate VBN cord-335975-m6lkrehi 2835 12 mass mass NN cord-335975-m6lkrehi 2835 13 flow flow NN cord-335975-m6lkrehi 2835 14 meter meter NN cord-335975-m6lkrehi 2835 15 ( ( -LRB- cord-335975-m6lkrehi 2835 16 Red Red NNP cord-335975-m6lkrehi 2835 17 Y Y NNP cord-335975-m6lkrehi 2835 18 Vogtlyn Vogtlyn NNP cord-335975-m6lkrehi 2835 19 ™ ™ NN cord-335975-m6lkrehi 2835 20 ) ) -RRB- cord-335975-m6lkrehi 2835 21 . . . cord-335975-m6lkrehi 2836 1 Results result NNS cord-335975-m6lkrehi 2836 2 : : : cord-335975-m6lkrehi 2837 1 When when WRB cord-335975-m6lkrehi 2837 2 MV MV NNP cord-335975-m6lkrehi 2837 3 increases increase VBZ cord-335975-m6lkrehi 2837 4 , , , cord-335975-m6lkrehi 2837 5 the the DT cord-335975-m6lkrehi 2837 6 FiO FiO NNP cord-335975-m6lkrehi 2837 7 2 2 CD cord-335975-m6lkrehi 2837 8 decreases decrease NNS cord-335975-m6lkrehi 2837 9 ( ( -LRB- cord-335975-m6lkrehi 2837 10 p p NN cord-335975-m6lkrehi 2837 11 < < XX cord-335975-m6lkrehi 2837 12 0.05 0.05 CD cord-335975-m6lkrehi 2837 13 ) ) -RRB- cord-335975-m6lkrehi 2837 14 . . . cord-335975-m6lkrehi 2838 1 When when WRB cord-335975-m6lkrehi 2838 2 Peep peep NN cord-335975-m6lkrehi 2838 3 increases increase NNS cord-335975-m6lkrehi 2838 4 , , , cord-335975-m6lkrehi 2838 5 FiO fio NN cord-335975-m6lkrehi 2838 6 2 2 CD cord-335975-m6lkrehi 2838 7 increases increase NNS cord-335975-m6lkrehi 2838 8 too too RB cord-335975-m6lkrehi 2838 9 ( ( -LRB- cord-335975-m6lkrehi 2838 10 p p NN cord-335975-m6lkrehi 2838 11 < < XX cord-335975-m6lkrehi 2838 12 0.05 0.05 CD cord-335975-m6lkrehi 2838 13 ) ) -RRB- cord-335975-m6lkrehi 2838 14 . . . cord-335975-m6lkrehi 2839 1 The the DT cord-335975-m6lkrehi 2839 2 addition addition NN cord-335975-m6lkrehi 2839 3 of of IN cord-335975-m6lkrehi 2839 4 an an DT cord-335975-m6lkrehi 2839 5 aerosol aerosol NN cord-335975-m6lkrehi 2839 6 ( ( -LRB- cord-335975-m6lkrehi 2839 7 O o UH cord-335975-m6lkrehi 2839 8 2 2 CD cord-335975-m6lkrehi 2839 9 -9 -9 NN cord-335975-m6lkrehi 2839 10 L l NN cord-335975-m6lkrehi 2839 11 min min NN cord-335975-m6lkrehi 2839 12 ) ) -RRB- cord-335975-m6lkrehi 2839 13 to to IN cord-335975-m6lkrehi 2839 14 a a DT cord-335975-m6lkrehi 2839 15 BS BS NNP cord-335975-m6lkrehi 2839 16 increases increase VBZ cord-335975-m6lkrehi 2839 17 the the DT cord-335975-m6lkrehi 2839 18 FiO FiO NNS cord-335975-m6lkrehi 2839 19 2 2 CD cord-335975-m6lkrehi 2839 20 ( ( -LRB- cord-335975-m6lkrehi 2839 21 p p NN cord-335975-m6lkrehi 2839 22 < < XX cord-335975-m6lkrehi 2839 23 0.05 0.05 CD cord-335975-m6lkrehi 2839 24 ) ) -RRB- cord-335975-m6lkrehi 2839 25 . . . cord-335975-m6lkrehi 2840 1 However however RB cord-335975-m6lkrehi 2840 2 , , , cord-335975-m6lkrehi 2840 3 in in IN cord-335975-m6lkrehi 2840 4 this this DT cord-335975-m6lkrehi 2840 5 last last JJ cord-335975-m6lkrehi 2840 6 case case NN cord-335975-m6lkrehi 2840 7 , , , cord-335975-m6lkrehi 2840 8 the the DT cord-335975-m6lkrehi 2840 9 gap gap NN cord-335975-m6lkrehi 2840 10 between between IN cord-335975-m6lkrehi 2840 11 both both DT cord-335975-m6lkrehi 2840 12 FiO FiO NNS cord-335975-m6lkrehi 2840 13 2 2 CD cord-335975-m6lkrehi 2840 14 decreases decrease VBZ cord-335975-m6lkrehi 2840 15 with with IN cord-335975-m6lkrehi 2840 16 increases increase NNS cord-335975-m6lkrehi 2840 17 MV MV NNP cord-335975-m6lkrehi 2840 18 ( ( -LRB- cord-335975-m6lkrehi 2840 19 Fig Fig NNP cord-335975-m6lkrehi 2840 20 . . . cord-335975-m6lkrehi 2840 21 1 1 CD cord-335975-m6lkrehi 2840 22 ) ) -RRB- cord-335975-m6lkrehi 2840 23 . . . cord-335975-m6lkrehi 2841 1 The the DT cord-335975-m6lkrehi 2841 2 addition addition NN cord-335975-m6lkrehi 2841 3 of of IN cord-335975-m6lkrehi 2841 4 an an DT cord-335975-m6lkrehi 2841 5 aerosol aerosol NN cord-335975-m6lkrehi 2841 6 connected connect VBN cord-335975-m6lkrehi 2841 7 to to IN cord-335975-m6lkrehi 2841 8 an an DT cord-335975-m6lkrehi 2841 9 O o NN cord-335975-m6lkrehi 2841 10 2 2 CD cord-335975-m6lkrehi 2841 11 flow flow NN cord-335975-m6lkrehi 2841 12 rate rate NN cord-335975-m6lkrehi 2841 13 ( ( -LRB- cord-335975-m6lkrehi 2841 14 9 9 CD cord-335975-m6lkrehi 2841 15 L l NN cord-335975-m6lkrehi 2841 16 min min NN cord-335975-m6lkrehi 2841 17 ) ) -RRB- cord-335975-m6lkrehi 2841 18 at at IN cord-335975-m6lkrehi 2841 19 the the DT cord-335975-m6lkrehi 2841 20 entry entry NN cord-335975-m6lkrehi 2841 21 of of IN cord-335975-m6lkrehi 2841 22 a a DT cord-335975-m6lkrehi 2841 23 BS BS NNP cord-335975-m6lkrehi 2841 24 limits limit VBZ cord-335975-m6lkrehi 2841 25 the the DT cord-335975-m6lkrehi 2841 26 FiO FiO NNS cord-335975-m6lkrehi 2841 27 2 2 CD cord-335975-m6lkrehi 2841 28 decreases decrease VBZ cord-335975-m6lkrehi 2841 29 during during IN cord-335975-m6lkrehi 2841 30 the the DT cord-335975-m6lkrehi 2841 31 MV MV NNP cord-335975-m6lkrehi 2841 32 increases increase NNS cord-335975-m6lkrehi 2841 33 . . . cord-335975-m6lkrehi 2842 1 Introduction introduction NN cord-335975-m6lkrehi 2842 2 : : : cord-335975-m6lkrehi 2843 1 Burned burn VBN cord-335975-m6lkrehi 2843 2 patients patient NNS cord-335975-m6lkrehi 2843 3 are be VBP cord-335975-m6lkrehi 2843 4 at at IN cord-335975-m6lkrehi 2843 5 high high JJ cord-335975-m6lkrehi 2843 6 risk risk NN cord-335975-m6lkrehi 2843 7 of of IN cord-335975-m6lkrehi 2843 8 yeast yeast NN cord-335975-m6lkrehi 2843 9 colonization colonization NN cord-335975-m6lkrehi 2843 10 and and CC cord-335975-m6lkrehi 2843 11 thus thus RB cord-335975-m6lkrehi 2843 12 of of IN cord-335975-m6lkrehi 2843 13 invasive invasive JJ cord-335975-m6lkrehi 2843 14 fungal fungal JJ cord-335975-m6lkrehi 2843 15 infections infection NNS cord-335975-m6lkrehi 2843 16 , , , cord-335975-m6lkrehi 2843 17 particularly particularly RB cord-335975-m6lkrehi 2843 18 to to IN cord-335975-m6lkrehi 2843 19 Candida Candida NNP cord-335975-m6lkrehi 2843 20 ( ( -LRB- cord-335975-m6lkrehi 2843 21 C. C. NNP cord-335975-m6lkrehi 2843 22 ) ) -RRB- cord-335975-m6lkrehi 2843 23 spp spp NN cord-335975-m6lkrehi 2843 24 . . . cord-335975-m6lkrehi 2844 1 , , , cord-335975-m6lkrehi 2844 2 leading lead VBG cord-335975-m6lkrehi 2844 3 to to IN cord-335975-m6lkrehi 2844 4 an an DT cord-335975-m6lkrehi 2844 5 increase increase NN cord-335975-m6lkrehi 2844 6 in in IN cord-335975-m6lkrehi 2844 7 morbidity morbidity NN cord-335975-m6lkrehi 2844 8 and and CC cord-335975-m6lkrehi 2844 9 mortality mortality NN cord-335975-m6lkrehi 2844 10 . . . cord-335975-m6lkrehi 2845 1 While while IN cord-335975-m6lkrehi 2845 2 pre pre JJ cord-335975-m6lkrehi 2845 3 - - JJ cord-335975-m6lkrehi 2845 4 emptive emptive JJ cord-335975-m6lkrehi 2845 5 antifungal antifungal NN cord-335975-m6lkrehi 2845 6 therapy therapy NN cord-335975-m6lkrehi 2845 7 has have VBZ cord-335975-m6lkrehi 2845 8 improved improve VBN cord-335975-m6lkrehi 2845 9 survival survival NN cord-335975-m6lkrehi 2845 10 , , , cord-335975-m6lkrehi 2845 11 it -PRON- PRP cord-335975-m6lkrehi 2845 12 may may MD cord-335975-m6lkrehi 2845 13 lead lead VB cord-335975-m6lkrehi 2845 14 to to IN cord-335975-m6lkrehi 2845 15 an an DT cord-335975-m6lkrehi 2845 16 increase increase NN cord-335975-m6lkrehi 2845 17 in in IN cord-335975-m6lkrehi 2845 18 antifungal antifungal JJ cord-335975-m6lkrehi 2845 19 resistance resistance NN cord-335975-m6lkrehi 2845 20 . . . cord-335975-m6lkrehi 2846 1 The the DT cord-335975-m6lkrehi 2846 2 objectives objective NNS cord-335975-m6lkrehi 2846 3 of of IN cord-335975-m6lkrehi 2846 4 this this DT cord-335975-m6lkrehi 2846 5 work work NN cord-335975-m6lkrehi 2846 6 were be VBD cord-335975-m6lkrehi 2846 7 to to TO cord-335975-m6lkrehi 2846 8 describe describe VB cord-335975-m6lkrehi 2846 9 Candida Candida NNP cord-335975-m6lkrehi 2846 10 species species NN cord-335975-m6lkrehi 2846 11 distribution distribution NN cord-335975-m6lkrehi 2846 12 and and CC cord-335975-m6lkrehi 2846 13 to to TO cord-335975-m6lkrehi 2846 14 determine determine VB cord-335975-m6lkrehi 2846 15 the the DT cord-335975-m6lkrehi 2846 16 antifungal antifungal JJ cord-335975-m6lkrehi 2846 17 susceptibility susceptibility NN cord-335975-m6lkrehi 2846 18 of of IN cord-335975-m6lkrehi 2846 19 Candida Candida NNP cord-335975-m6lkrehi 2846 20 isolates isolate NNS cord-335975-m6lkrehi 2846 21 acquired acquire VBN cord-335975-m6lkrehi 2846 22 in in IN cord-335975-m6lkrehi 2846 23 a a DT cord-335975-m6lkrehi 2846 24 burn burn NN cord-335975-m6lkrehi 2846 25 unit unit NN cord-335975-m6lkrehi 2846 26 . . . cord-335975-m6lkrehi 2847 1 Our -PRON- PRP$ cord-335975-m6lkrehi 2847 2 study study NN cord-335975-m6lkrehi 2847 3 is be VBZ cord-335975-m6lkrehi 2847 4 a a DT cord-335975-m6lkrehi 2847 5 retrospective retrospective JJ cord-335975-m6lkrehi 2847 6 review review NN cord-335975-m6lkrehi 2847 7 of of IN cord-335975-m6lkrehi 2847 8 17 17 CD cord-335975-m6lkrehi 2847 9 severely severely RB cord-335975-m6lkrehi 2847 10 burned burn VBN cord-335975-m6lkrehi 2847 11 patients patient NNS cord-335975-m6lkrehi 2847 12 admitted admit VBN cord-335975-m6lkrehi 2847 13 to to IN cord-335975-m6lkrehi 2847 14 the the DT cord-335975-m6lkrehi 2847 15 burn burn NN cord-335975-m6lkrehi 2847 16 unit unit NN cord-335975-m6lkrehi 2847 17 of of IN cord-335975-m6lkrehi 2847 18 the the DT cord-335975-m6lkrehi 2847 19 Ben Ben NNP cord-335975-m6lkrehi 2847 20 Arous Arous NNP cord-335975-m6lkrehi 2847 21 Traumatology Traumatology NNP cord-335975-m6lkrehi 2847 22 and and CC cord-335975-m6lkrehi 2847 23 Burns Burns NNP cord-335975-m6lkrehi 2847 24 Center Center NNP cord-335975-m6lkrehi 2847 25 with with IN cord-335975-m6lkrehi 2847 26 one one CD cord-335975-m6lkrehi 2847 27 or or CC cord-335975-m6lkrehi 2847 28 more more RBR cord-335975-m6lkrehi 2847 29 positive positive JJ cord-335975-m6lkrehi 2847 30 culture culture NN cord-335975-m6lkrehi 2847 31 sites site NNS cord-335975-m6lkrehi 2847 32 for for IN cord-335975-m6lkrehi 2847 33 Candida Candida NNP cord-335975-m6lkrehi 2847 34 , , , cord-335975-m6lkrehi 2847 35 during during IN cord-335975-m6lkrehi 2847 36 the the DT cord-335975-m6lkrehi 2847 37 16-month 16-month JJ cord-335975-m6lkrehi 2847 38 period period NN cord-335975-m6lkrehi 2847 39 from from IN cord-335975-m6lkrehi 2847 40 May May NNP cord-335975-m6lkrehi 2847 41 2016 2016 CD cord-335975-m6lkrehi 2847 42 through through IN cord-335975-m6lkrehi 2847 43 August August NNP cord-335975-m6lkrehi 2847 44 2017 2017 CD cord-335975-m6lkrehi 2847 45 . . . cord-335975-m6lkrehi 2848 1 A a DT cord-335975-m6lkrehi 2848 2 total total NN cord-335975-m6lkrehi 2848 3 of of IN cord-335975-m6lkrehi 2848 4 42 42 CD cord-335975-m6lkrehi 2848 5 isolates isolate NNS cord-335975-m6lkrehi 2848 6 were be VBD cord-335975-m6lkrehi 2848 7 thus thus RB cord-335975-m6lkrehi 2848 8 obtained obtain VBN cord-335975-m6lkrehi 2848 9 . . . cord-335975-m6lkrehi 2849 1 The the DT cord-335975-m6lkrehi 2849 2 susceptibility susceptibility NN cord-335975-m6lkrehi 2849 3 to to IN cord-335975-m6lkrehi 2849 4 6 6 CD cord-335975-m6lkrehi 2849 5 antifungal antifungal JJ cord-335975-m6lkrehi 2849 6 drugs drug NNS cord-335975-m6lkrehi 2849 7 ( ( -LRB- cord-335975-m6lkrehi 2849 8 5-fluorocytosine 5-fluorocytosine CD cord-335975-m6lkrehi 2849 9 , , , cord-335975-m6lkrehi 2849 10 fluconazole fluconazole NN cord-335975-m6lkrehi 2849 11 , , , cord-335975-m6lkrehi 2849 12 ketoconazole ketoconazole NNP cord-335975-m6lkrehi 2849 13 , , , cord-335975-m6lkrehi 2849 14 micronazole micronazole NNP cord-335975-m6lkrehi 2849 15 , , , cord-335975-m6lkrehi 2849 16 itraconazole itraconazole NNP cord-335975-m6lkrehi 2849 17 , , , cord-335975-m6lkrehi 2849 18 amphotericin amphotericin NNS cord-335975-m6lkrehi 2849 19 B B NNP cord-335975-m6lkrehi 2849 20 ) ) -RRB- cord-335975-m6lkrehi 2849 21 was be VBD cord-335975-m6lkrehi 2849 22 determined determine VBN cord-335975-m6lkrehi 2849 23 using use VBG cord-335975-m6lkrehi 2849 24 the the DT cord-335975-m6lkrehi 2849 25 Fungitest Fungitest NNP cord-335975-m6lkrehi 2850 1 ® ® VB cord-335975-m6lkrehi 2850 2 broth broth NN cord-335975-m6lkrehi 2850 3 dilution dilution NN cord-335975-m6lkrehi 2850 4 method method NN cord-335975-m6lkrehi 2850 5 for for IN cord-335975-m6lkrehi 2850 6 patients patient NNS cord-335975-m6lkrehi 2850 7 with with IN cord-335975-m6lkrehi 2850 8 infected infected JJ cord-335975-m6lkrehi 2850 9 normally normally RB cord-335975-m6lkrehi 2850 10 sterile sterile JJ cord-335975-m6lkrehi 2850 11 body body NN cord-335975-m6lkrehi 2850 12 sites site NNS cord-335975-m6lkrehi 2850 13 or or CC cord-335975-m6lkrehi 2850 14 a a DT cord-335975-m6lkrehi 2850 15 Candida Candida NNP cord-335975-m6lkrehi 2850 16 colonization colonization NN cord-335975-m6lkrehi 2850 17 index index NN cord-335975-m6lkrehi 2850 18 superior superior JJ cord-335975-m6lkrehi 2850 19 or or CC cord-335975-m6lkrehi 2850 20 equal equal JJ cord-335975-m6lkrehi 2850 21 to to IN cord-335975-m6lkrehi 2850 22 0.4 0.4 CD cord-335975-m6lkrehi 2850 23 . . . cord-335975-m6lkrehi 2851 1 Since since IN cord-335975-m6lkrehi 2851 2 echinocandin echinocandin NNP cord-335975-m6lkrehi 2851 3 and and CC cord-335975-m6lkrehi 2851 4 anidulafungine anidulafungine NNP cord-335975-m6lkrehi 2851 5 were be VBD cord-335975-m6lkrehi 2851 6 recently recently RB cord-335975-m6lkrehi 2851 7 introduced introduce VBN cord-335975-m6lkrehi 2851 8 in in IN cord-335975-m6lkrehi 2851 9 Tunisia Tunisia NNP cord-335975-m6lkrehi 2851 10 , , , cord-335975-m6lkrehi 2851 11 the the DT cord-335975-m6lkrehi 2851 12 susceptibility susceptibility NN cord-335975-m6lkrehi 2851 13 to to IN cord-335975-m6lkrehi 2851 14 these these DT cord-335975-m6lkrehi 2851 15 antifungal antifungal JJ cord-335975-m6lkrehi 2851 16 classes class NNS cord-335975-m6lkrehi 2851 17 was be VBD cord-335975-m6lkrehi 2851 18 tested test VBN cord-335975-m6lkrehi 2851 19 for for IN cord-335975-m6lkrehi 2851 20 only only RB cord-335975-m6lkrehi 2851 21 one one CD cord-335975-m6lkrehi 2851 22 patient patient NN cord-335975-m6lkrehi 2851 23 from from IN cord-335975-m6lkrehi 2851 24 our -PRON- PRP$ cord-335975-m6lkrehi 2851 25 cohort cohort NN cord-335975-m6lkrehi 2851 26 . . . cord-335975-m6lkrehi 2852 1 Results result NNS cord-335975-m6lkrehi 2852 2 : : : cord-335975-m6lkrehi 2853 1 Nasal nasal JJ cord-335975-m6lkrehi 2853 2 and and CC cord-335975-m6lkrehi 2853 3 buccal buccal JJ cord-335975-m6lkrehi 2853 4 sites site NNS cord-335975-m6lkrehi 2853 5 were be VBD cord-335975-m6lkrehi 2853 6 the the DT cord-335975-m6lkrehi 2853 7 most most RBS cord-335975-m6lkrehi 2853 8 colonized colonize VBN cord-335975-m6lkrehi 2853 9 body body NN cord-335975-m6lkrehi 2853 10 sites site NNS cord-335975-m6lkrehi 2853 11 ( ( -LRB- cord-335975-m6lkrehi 2853 12 21.4 21.4 CD cord-335975-m6lkrehi 2853 13 % % NN cord-335975-m6lkrehi 2853 14 each each DT cord-335975-m6lkrehi 2853 15 ) ) -RRB- cord-335975-m6lkrehi 2853 16 , , , cord-335975-m6lkrehi 2853 17 followed follow VBN cord-335975-m6lkrehi 2853 18 by by IN cord-335975-m6lkrehi 2853 19 axillary axillary JJ cord-335975-m6lkrehi 2853 20 ( ( -LRB- cord-335975-m6lkrehi 2853 21 11.9 11.9 CD cord-335975-m6lkrehi 2853 22 % % NN cord-335975-m6lkrehi 2853 23 ) ) -RRB- cord-335975-m6lkrehi 2853 24 and and CC cord-335975-m6lkrehi 2853 25 rectal rectal JJ cord-335975-m6lkrehi 2853 26 sites site NNS cord-335975-m6lkrehi 2853 27 ( ( -LRB- cord-335975-m6lkrehi 2853 28 9.5 9.5 CD cord-335975-m6lkrehi 2853 29 % % NN cord-335975-m6lkrehi 2853 30 ) ) -RRB- cord-335975-m6lkrehi 2853 31 and and CC cord-335975-m6lkrehi 2853 32 urines urine NNS cord-335975-m6lkrehi 2853 33 ( ( -LRB- cord-335975-m6lkrehi 2853 34 9.5 9.5 CD cord-335975-m6lkrehi 2853 35 % % NN cord-335975-m6lkrehi 2853 36 ) ) -RRB- cord-335975-m6lkrehi 2853 37 . . . cord-335975-m6lkrehi 2854 1 C. C. NNP cord-335975-m6lkrehi 2854 2 albicans albican NNS cord-335975-m6lkrehi 2854 3 was be VBD cord-335975-m6lkrehi 2854 4 the the DT cord-335975-m6lkrehi 2854 5 predominant predominant JJ cord-335975-m6lkrehi 2854 6 species specie NNS cord-335975-m6lkrehi 2854 7 ( ( -LRB- cord-335975-m6lkrehi 2854 8 45.2 45.2 CD cord-335975-m6lkrehi 2854 9 % % NN cord-335975-m6lkrehi 2854 10 ) ) -RRB- cord-335975-m6lkrehi 2854 11 , , , cord-335975-m6lkrehi 2854 12 followed follow VBN cord-335975-m6lkrehi 2854 13 by by IN cord-335975-m6lkrehi 2854 14 C. C. NNP cord-335975-m6lkrehi 2854 15 glabrata glabrata NNP cord-335975-m6lkrehi 2854 16 ( ( -LRB- cord-335975-m6lkrehi 2854 17 38.1 38.1 CD cord-335975-m6lkrehi 2854 18 % % NN cord-335975-m6lkrehi 2854 19 ) ) -RRB- cord-335975-m6lkrehi 2854 20 , , , cord-335975-m6lkrehi 2854 21 C. C. NNP cord-335975-m6lkrehi 2854 22 tropicalis tropicalis NNP cord-335975-m6lkrehi 2854 23 ( ( -LRB- cord-335975-m6lkrehi 2854 24 7.1 7.1 CD cord-335975-m6lkrehi 2854 25 % % NN cord-335975-m6lkrehi 2854 26 ) ) -RRB- cord-335975-m6lkrehi 2854 27 and and CC cord-335975-m6lkrehi 2854 28 C. C. NNP cord-335975-m6lkrehi 2854 29 parapsilosis parapsilosis NNP cord-335975-m6lkrehi 2854 30 ( ( -LRB- cord-335975-m6lkrehi 2854 31 4.8 4.8 CD cord-335975-m6lkrehi 2854 32 % % NN cord-335975-m6lkrehi 2854 33 ) ) -RRB- cord-335975-m6lkrehi 2854 34 . . . cord-335975-m6lkrehi 2855 1 Among among IN cord-335975-m6lkrehi 2855 2 the the DT cord-335975-m6lkrehi 2855 3 strains strain NNS cord-335975-m6lkrehi 2855 4 whose whose WP$ cord-335975-m6lkrehi 2855 5 antifungal antifungal JJ cord-335975-m6lkrehi 2855 6 susceptibility susceptibility NN cord-335975-m6lkrehi 2855 7 was be VBD cord-335975-m6lkrehi 2855 8 determined determine VBN cord-335975-m6lkrehi 2855 9 , , , cord-335975-m6lkrehi 2855 10 majority majority NN cord-335975-m6lkrehi 2855 11 of of IN cord-335975-m6lkrehi 2855 12 Candida Candida NNP cord-335975-m6lkrehi 2855 13 isolates isolate NNS cord-335975-m6lkrehi 2855 14 were be VBD cord-335975-m6lkrehi 2855 15 susceptible susceptible JJ cord-335975-m6lkrehi 2855 16 to to IN cord-335975-m6lkrehi 2855 17 fluconazole fluconazole NN cord-335975-m6lkrehi 2855 18 ( ( -LRB- cord-335975-m6lkrehi 2855 19 77.8 77.8 CD cord-335975-m6lkrehi 2855 20 % % NN cord-335975-m6lkrehi 2855 21 ) ) -RRB- cord-335975-m6lkrehi 2855 22 , , , cord-335975-m6lkrehi 2855 23 which which WDT cord-335975-m6lkrehi 2855 24 is be VBZ cord-335975-m6lkrehi 2855 25 the the DT cord-335975-m6lkrehi 2855 26 most most RBS cord-335975-m6lkrehi 2855 27 frequently frequently RB cord-335975-m6lkrehi 2855 28 used use VBN cord-335975-m6lkrehi 2855 29 molecule molecule NN cord-335975-m6lkrehi 2855 30 as as IN cord-335975-m6lkrehi 2855 31 a a DT cord-335975-m6lkrehi 2855 32 pre pre JJ cord-335975-m6lkrehi 2855 33 - - JJ cord-335975-m6lkrehi 2855 34 emptive emptive JJ cord-335975-m6lkrehi 2855 35 treatment treatment NN cord-335975-m6lkrehi 2855 36 in in IN cord-335975-m6lkrehi 2855 37 such such JJ cord-335975-m6lkrehi 2855 38 cases case NNS cord-335975-m6lkrehi 2855 39 in in IN cord-335975-m6lkrehi 2855 40 Tunisia Tunisia NNP cord-335975-m6lkrehi 2855 41 due due IN cord-335975-m6lkrehi 2855 42 to to IN cord-335975-m6lkrehi 2855 43 its -PRON- PRP$ cord-335975-m6lkrehi 2855 44 availability availability NN cord-335975-m6lkrehi 2855 45 and and CC cord-335975-m6lkrehi 2855 46 its -PRON- PRP$ cord-335975-m6lkrehi 2855 47 efficiency efficiency NN cord-335975-m6lkrehi 2855 48 . . . cord-335975-m6lkrehi 2856 1 On on IN cord-335975-m6lkrehi 2856 2 the the DT cord-335975-m6lkrehi 2856 3 other other JJ cord-335975-m6lkrehi 2856 4 hand hand NN cord-335975-m6lkrehi 2856 5 , , , cord-335975-m6lkrehi 2856 6 11.1 11.1 CD cord-335975-m6lkrehi 2856 7 % % NN cord-335975-m6lkrehi 2856 8 of of IN cord-335975-m6lkrehi 2856 9 the the DT cord-335975-m6lkrehi 2856 10 isolates isolate NNS cord-335975-m6lkrehi 2856 11 were be VBD cord-335975-m6lkrehi 2856 12 intermediate intermediate JJ cord-335975-m6lkrehi 2856 13 and and CC cord-335975-m6lkrehi 2856 14 11.1 11.1 CD cord-335975-m6lkrehi 2856 15 % % NN cord-335975-m6lkrehi 2856 16 were be VBD cord-335975-m6lkrehi 2856 17 resistant resistant JJ cord-335975-m6lkrehi 2856 18 to to IN cord-335975-m6lkrehi 2856 19 this this DT cord-335975-m6lkrehi 2856 20 antifungal antifungal JJ cord-335975-m6lkrehi 2856 21 drug drug NN cord-335975-m6lkrehi 2856 22 , , , cord-335975-m6lkrehi 2856 23 mainly mainly RB cord-335975-m6lkrehi 2856 24 C. C. NNP cord-335975-m6lkrehi 2856 25 glabrata glabrata NN cord-335975-m6lkrehi 2856 26 for for IN cord-335975-m6lkrehi 2856 27 both both DT cord-335975-m6lkrehi 2856 28 groups group NNS cord-335975-m6lkrehi 2856 29 . . . cord-335975-m6lkrehi 2857 1 As as IN cord-335975-m6lkrehi 2857 2 for for IN cord-335975-m6lkrehi 2857 3 the the DT cord-335975-m6lkrehi 2857 4 other other JJ cord-335975-m6lkrehi 2857 5 tested test VBN cord-335975-m6lkrehi 2857 6 azoles azole NNS cord-335975-m6lkrehi 2857 7 , , , cord-335975-m6lkrehi 2857 8 high high JJ cord-335975-m6lkrehi 2857 9 rates rate NNS cord-335975-m6lkrehi 2857 10 of of IN cord-335975-m6lkrehi 2857 11 intermediate intermediate JJ cord-335975-m6lkrehi 2857 12 strains strain NNS cord-335975-m6lkrehi 2857 13 were be VBD cord-335975-m6lkrehi 2857 14 noticed notice VBN cord-335975-m6lkrehi 2857 15 ( ( -LRB- cord-335975-m6lkrehi 2857 16 81.5 81.5 CD cord-335975-m6lkrehi 2857 17 % % NN cord-335975-m6lkrehi 2857 18 to to IN cord-335975-m6lkrehi 2857 19 itraconazole itraconazole NNP cord-335975-m6lkrehi 2857 20 , , , cord-335975-m6lkrehi 2857 21 40.7 40.7 CD cord-335975-m6lkrehi 2857 22 % % NN cord-335975-m6lkrehi 2857 23 to to IN cord-335975-m6lkrehi 2857 24 ketoconazole ketoconazole NNP cord-335975-m6lkrehi 2857 25 and and CC cord-335975-m6lkrehi 2857 26 33.3 33.3 CD cord-335975-m6lkrehi 2857 27 % % NN cord-335975-m6lkrehi 2857 28 to to IN cord-335975-m6lkrehi 2857 29 miconazole miconazole NNP cord-335975-m6lkrehi 2857 30 ) ) -RRB- cord-335975-m6lkrehi 2857 31 , , , cord-335975-m6lkrehi 2857 32 mostly mostly RB cord-335975-m6lkrehi 2857 33 C. C. NNP cord-335975-m6lkrehi 2857 34 glabrata glabrata NN cord-335975-m6lkrehi 2857 35 . . . cord-335975-m6lkrehi 2858 1 Only only RB cord-335975-m6lkrehi 2858 2 one one CD cord-335975-m6lkrehi 2858 3 strain strain NN cord-335975-m6lkrehi 2858 4 was be VBD cord-335975-m6lkrehi 2858 5 resistant resistant JJ cord-335975-m6lkrehi 2858 6 to to IN cord-335975-m6lkrehi 2858 7 amphotericin amphotericin NNS cord-335975-m6lkrehi 2858 8 B b NN cord-335975-m6lkrehi 2858 9 , , , cord-335975-m6lkrehi 2858 10 which which WDT cord-335975-m6lkrehi 2858 11 is be VBZ cord-335975-m6lkrehi 2858 12 not not RB cord-335975-m6lkrehi 2858 13 usually usually RB cord-335975-m6lkrehi 2858 14 used use VBN cord-335975-m6lkrehi 2858 15 in in IN cord-335975-m6lkrehi 2858 16 these these DT cord-335975-m6lkrehi 2858 17 cases case NNS cord-335975-m6lkrehi 2858 18 due due JJ cord-335975-m6lkrehi 2858 19 to to IN cord-335975-m6lkrehi 2858 20 its -PRON- PRP$ cord-335975-m6lkrehi 2858 21 nephrotoxicity nephrotoxicity NN cord-335975-m6lkrehi 2858 22 and and CC cord-335975-m6lkrehi 2858 23 the the DT cord-335975-m6lkrehi 2858 24 frequency frequency NN cord-335975-m6lkrehi 2858 25 of of IN cord-335975-m6lkrehi 2858 26 kidney kidney NN cord-335975-m6lkrehi 2858 27 failure failure NN cord-335975-m6lkrehi 2858 28 in in IN cord-335975-m6lkrehi 2858 29 burned burn VBN cord-335975-m6lkrehi 2858 30 patients patient NNS cord-335975-m6lkrehi 2858 31 . . . cord-335975-m6lkrehi 2859 1 Our -PRON- PRP$ cord-335975-m6lkrehi 2859 2 study study NN cord-335975-m6lkrehi 2859 3 demonstrates demonstrate VBZ cord-335975-m6lkrehi 2859 4 that that IN cord-335975-m6lkrehi 2859 5 C. C. NNP cord-335975-m6lkrehi 2859 6 albicans albican NNS cord-335975-m6lkrehi 2859 7 is be VBZ cord-335975-m6lkrehi 2859 8 the the DT cord-335975-m6lkrehi 2859 9 most most RBS cord-335975-m6lkrehi 2859 10 frequent frequent JJ cord-335975-m6lkrehi 2859 11 species specie NNS cord-335975-m6lkrehi 2859 12 in in IN cord-335975-m6lkrehi 2859 13 burn burn NN cord-335975-m6lkrehi 2859 14 unit unit NN cord-335975-m6lkrehi 2859 15 - - HYPH cord-335975-m6lkrehi 2859 16 acquired acquire VBN cord-335975-m6lkrehi 2859 17 candidiasis candidiasis NN cord-335975-m6lkrehi 2859 18 . . . cord-335975-m6lkrehi 2860 1 No no DT cord-335975-m6lkrehi 2860 2 major major JJ cord-335975-m6lkrehi 2860 3 antifungal antifungal JJ cord-335975-m6lkrehi 2860 4 resistance resistance NN cord-335975-m6lkrehi 2860 5 was be VBD cord-335975-m6lkrehi 2860 6 observed observe VBN cord-335975-m6lkrehi 2860 7 , , , cord-335975-m6lkrehi 2860 8 apart apart RB cord-335975-m6lkrehi 2860 9 from from IN cord-335975-m6lkrehi 2860 10 high high JJ cord-335975-m6lkrehi 2860 11 rates rate NNS cord-335975-m6lkrehi 2860 12 of of IN cord-335975-m6lkrehi 2860 13 intermediate intermediate JJ cord-335975-m6lkrehi 2860 14 strains strain NNS cord-335975-m6lkrehi 2860 15 ( ( -LRB- cord-335975-m6lkrehi 2860 16 mainly mainly RB cord-335975-m6lkrehi 2860 17 C. C. NNP cord-335975-m6lkrehi 2860 18 glabrata glabrata NN cord-335975-m6lkrehi 2860 19 ) ) -RRB- cord-335975-m6lkrehi 2860 20 to to TO cord-335975-m6lkrehi 2860 21 azole azole VB cord-335975-m6lkrehi 2860 22 class class NN cord-335975-m6lkrehi 2860 23 antifungal antifungal NN cord-335975-m6lkrehi 2860 24 drugs drug NNS cord-335975-m6lkrehi 2860 25 . . . cord-335975-m6lkrehi 2861 1 Introduction introduction NN cord-335975-m6lkrehi 2861 2 : : : cord-335975-m6lkrehi 2861 3 Infection infection NN cord-335975-m6lkrehi 2861 4 , , , cord-335975-m6lkrehi 2861 5 especially especially RB cord-335975-m6lkrehi 2861 6 bacteremia bacteremia NN cord-335975-m6lkrehi 2861 7 , , , cord-335975-m6lkrehi 2861 8 is be VBZ cord-335975-m6lkrehi 2861 9 a a DT cord-335975-m6lkrehi 2861 10 major major JJ cord-335975-m6lkrehi 2861 11 cause cause NN cord-335975-m6lkrehi 2861 12 of of IN cord-335975-m6lkrehi 2861 13 morbi morbi NN cord-335975-m6lkrehi 2861 14 - - HYPH cord-335975-m6lkrehi 2861 15 mortality mortality NN cord-335975-m6lkrehi 2861 16 in in IN cord-335975-m6lkrehi 2861 17 severely severely RB cord-335975-m6lkrehi 2861 18 burned burn VBN cord-335975-m6lkrehi 2861 19 patients patient NNS cord-335975-m6lkrehi 2861 20 . . . cord-335975-m6lkrehi 2862 1 Mortalityrelated mortalityrelate VBN cord-335975-m6lkrehi 2862 2 to to IN cord-335975-m6lkrehi 2862 3 bacteremia bacteremia NN cord-335975-m6lkrehi 2862 4 in in IN cord-335975-m6lkrehi 2862 5 burn burn NN cord-335975-m6lkrehi 2862 6 patients patient NNS cord-335975-m6lkrehi 2862 7 was be VBD cord-335975-m6lkrehi 2862 8 about about RB cord-335975-m6lkrehi 2862 9 30 30 CD cord-335975-m6lkrehi 2862 10 % % NN cord-335975-m6lkrehi 2862 11 [ [ -LRB- cord-335975-m6lkrehi 2862 12 1 1 CD cord-335975-m6lkrehi 2862 13 ] ] -RRB- cord-335975-m6lkrehi 2862 14 . . . cord-335975-m6lkrehi 2863 1 We -PRON- PRP cord-335975-m6lkrehi 2863 2 performed perform VBD cord-335975-m6lkrehi 2863 3 this this DT cord-335975-m6lkrehi 2863 4 study study NN cord-335975-m6lkrehi 2863 5 to to TO cord-335975-m6lkrehi 2863 6 determine determine VB cord-335975-m6lkrehi 2863 7 the the DT cord-335975-m6lkrehi 2863 8 prevalence prevalence NN cord-335975-m6lkrehi 2863 9 , , , cord-335975-m6lkrehi 2863 10 the the DT cord-335975-m6lkrehi 2863 11 causative causative JJ cord-335975-m6lkrehi 2863 12 agents agent NNS cord-335975-m6lkrehi 2863 13 and and CC cord-335975-m6lkrehi 2863 14 outcomes outcome NNS cord-335975-m6lkrehi 2863 15 of of IN cord-335975-m6lkrehi 2863 16 bacteremia bacteremia NN cord-335975-m6lkrehi 2863 17 in in IN cord-335975-m6lkrehi 2863 18 burned burn VBN cord-335975-m6lkrehi 2863 19 patients patient NNS cord-335975-m6lkrehi 2863 20 . . . cord-335975-m6lkrehi 2864 1 Introduction introduction NN cord-335975-m6lkrehi 2864 2 : : : cord-335975-m6lkrehi 2865 1 Carbapenems Carbapenems NNP cord-335975-m6lkrehi 2865 2 , , , cord-335975-m6lkrehi 2865 3 the the DT cord-335975-m6lkrehi 2865 4 last last JJ cord-335975-m6lkrehi 2865 5 line line NN cord-335975-m6lkrehi 2865 6 of of IN cord-335975-m6lkrehi 2865 7 therapy therapy NN cord-335975-m6lkrehi 2865 8 , , , cord-335975-m6lkrehi 2865 9 are be VBP cord-335975-m6lkrehi 2865 10 now now RB cord-335975-m6lkrehi 2865 11 frequently frequently RB cord-335975-m6lkrehi 2865 12 needed need VBN cord-335975-m6lkrehi 2865 13 to to TO cord-335975-m6lkrehi 2865 14 treat treat VB cord-335975-m6lkrehi 2865 15 nosocomial nosocomial JJ cord-335975-m6lkrehi 2865 16 infections infection NNS cord-335975-m6lkrehi 2865 17 , , , cord-335975-m6lkrehi 2865 18 and and CC cord-335975-m6lkrehi 2865 19 increasing increase VBG cord-335975-m6lkrehi 2865 20 resistance resistance NN cord-335975-m6lkrehi 2865 21 to to IN cord-335975-m6lkrehi 2865 22 this this DT cord-335975-m6lkrehi 2865 23 class class NN cord-335975-m6lkrehi 2865 24 of of IN cord-335975-m6lkrehi 2865 25 β β NNP cord-335975-m6lkrehi 2865 26 - - HYPH cord-335975-m6lkrehi 2865 27 lactams lactam NNS cord-335975-m6lkrehi 2865 28 limit limit VBP cord-335975-m6lkrehi 2865 29 antibiotic antibiotic JJ cord-335975-m6lkrehi 2865 30 options option NNS cord-335975-m6lkrehi 2865 31 in in IN cord-335975-m6lkrehi 2865 32 critically critically RB cord-335975-m6lkrehi 2865 33 ill ill JJ cord-335975-m6lkrehi 2865 34 patients patient NNS cord-335975-m6lkrehi 2865 35 especially especially RB cord-335975-m6lkrehi 2865 36 in in IN cord-335975-m6lkrehi 2865 37 burns burn NNS cord-335975-m6lkrehi 2865 38 . . . cord-335975-m6lkrehi 2866 1 The the DT cord-335975-m6lkrehi 2866 2 objective objective NN cord-335975-m6lkrehi 2866 3 of of IN cord-335975-m6lkrehi 2866 4 our -PRON- PRP$ cord-335975-m6lkrehi 2866 5 study study NN cord-335975-m6lkrehi 2866 6 was be VBD cord-335975-m6lkrehi 2866 7 to to TO cord-335975-m6lkrehi 2866 8 assess assess VB cord-335975-m6lkrehi 2866 9 the the DT cord-335975-m6lkrehi 2866 10 impact impact NN cord-335975-m6lkrehi 2866 11 of of IN cord-335975-m6lkrehi 2866 12 the the DT cord-335975-m6lkrehi 2866 13 detection detection NN cord-335975-m6lkrehi 2866 14 of of IN cord-335975-m6lkrehi 2866 15 carbaménépases carbaménépase NNS cord-335975-m6lkrehi 2866 16 in in IN cord-335975-m6lkrehi 2866 17 optimizing optimize VBG cord-335975-m6lkrehi 2866 18 treatments treatment NNS cord-335975-m6lkrehi 2866 19 in in IN cord-335975-m6lkrehi 2866 20 burned burn VBN cord-335975-m6lkrehi 2866 21 . . . cord-335975-m6lkrehi 2867 1 Patients patient NNS cord-335975-m6lkrehi 2867 2 and and CC cord-335975-m6lkrehi 2867 3 methods method NNS cord-335975-m6lkrehi 2867 4 : : : cord-335975-m6lkrehi 2867 5 A a DT cord-335975-m6lkrehi 2867 6 prospective prospective JJ cord-335975-m6lkrehi 2867 7 , , , cord-335975-m6lkrehi 2867 8 monocentric monocentric JJ cord-335975-m6lkrehi 2867 9 study study NN cord-335975-m6lkrehi 2867 10 was be VBD cord-335975-m6lkrehi 2867 11 carried carry VBN cord-335975-m6lkrehi 2867 12 out out RP cord-335975-m6lkrehi 2867 13 at at IN cord-335975-m6lkrehi 2867 14 the the DT cord-335975-m6lkrehi 2867 15 intensive intensive JJ cord-335975-m6lkrehi 2867 16 care care NN cord-335975-m6lkrehi 2867 17 unit unit NN cord-335975-m6lkrehi 2867 18 of of IN cord-335975-m6lkrehi 2867 19 burn burn NN cord-335975-m6lkrehi 2867 20 in in IN cord-335975-m6lkrehi 2867 21 Tunisia Tunisia NNP cord-335975-m6lkrehi 2867 22 over over IN cord-335975-m6lkrehi 2867 23 6 6 CD cord-335975-m6lkrehi 2867 24 months month NNS cord-335975-m6lkrehi 2867 25 ( ( -LRB- cord-335975-m6lkrehi 2867 26 March March NNP cord-335975-m6lkrehi 2867 27 - - HYPH cord-335975-m6lkrehi 2867 28 August August NNP cord-335975-m6lkrehi 2867 29 2017 2017 CD cord-335975-m6lkrehi 2867 30 ) ) -RRB- cord-335975-m6lkrehi 2867 31 . . . cord-335975-m6lkrehi 2868 1 Were be VBD cord-335975-m6lkrehi 2868 2 included include VBN cord-335975-m6lkrehi 2868 3 all all DT cord-335975-m6lkrehi 2868 4 patients patient NNS cord-335975-m6lkrehi 2868 5 who who WP cord-335975-m6lkrehi 2868 6 have have VBP cord-335975-m6lkrehi 2868 7 had have VBN cord-335975-m6lkrehi 2868 8 a a DT cord-335975-m6lkrehi 2868 9 carbapenemase carbapenemase NN cord-335975-m6lkrehi 2868 10 research research NN cord-335975-m6lkrehi 2868 11 . . . cord-335975-m6lkrehi 2869 1 The the DT cord-335975-m6lkrehi 2869 2 sample sample NN cord-335975-m6lkrehi 2869 3 was be VBD cord-335975-m6lkrehi 2869 4 carried carry VBN cord-335975-m6lkrehi 2869 5 out out RP cord-335975-m6lkrehi 2869 6 by by IN cord-335975-m6lkrehi 2869 7 rectal rectal JJ cord-335975-m6lkrehi 2869 8 swab swab NN cord-335975-m6lkrehi 2869 9 . . . cord-335975-m6lkrehi 2870 1 All all DT cord-335975-m6lkrehi 2870 2 samples sample NNS cord-335975-m6lkrehi 2870 3 were be VBD cord-335975-m6lkrehi 2870 4 analyzed analyze VBN cord-335975-m6lkrehi 2870 5 by by IN cord-335975-m6lkrehi 2870 6 polymerase polymerase NN cord-335975-m6lkrehi 2870 7 chain chain NN cord-335975-m6lkrehi 2870 8 reaction reaction NN cord-335975-m6lkrehi 2870 9 ( ( -LRB- cord-335975-m6lkrehi 2870 10 PCR PCR NNP cord-335975-m6lkrehi 2870 11 ) ) -RRB- cord-335975-m6lkrehi 2870 12 methods method NNS cord-335975-m6lkrehi 2870 13 for for IN cord-335975-m6lkrehi 2870 14 presence presence NN cord-335975-m6lkrehi 2870 15 of of IN cord-335975-m6lkrehi 2870 16 carbapenemase carbapenemase NN cord-335975-m6lkrehi 2870 17 . . . cord-335975-m6lkrehi 2871 1 During during IN cord-335975-m6lkrehi 2871 2 the the DT cord-335975-m6lkrehi 2871 3 study study NN cord-335975-m6lkrehi 2871 4 period period NN cord-335975-m6lkrehi 2871 5 , , , cord-335975-m6lkrehi 2871 6 30 30 CD cord-335975-m6lkrehi 2871 7 patients patient NNS cord-335975-m6lkrehi 2871 8 were be VBD cord-335975-m6lkrehi 2871 9 included include VBN cord-335975-m6lkrehi 2871 10 . . . cord-335975-m6lkrehi 2872 1 The the DT cord-335975-m6lkrehi 2872 2 mean mean JJ cord-335975-m6lkrehi 2872 3 age age NN cord-335975-m6lkrehi 2872 4 was be VBD cord-335975-m6lkrehi 2872 5 30 30 CD cord-335975-m6lkrehi 2872 6 ± ± CD cord-335975-m6lkrehi 2872 7 11 11 CD cord-335975-m6lkrehi 2872 8 years year NNS cord-335975-m6lkrehi 2872 9 . . . cord-335975-m6lkrehi 2873 1 They -PRON- PRP cord-335975-m6lkrehi 2873 2 were be VBD cord-335975-m6lkrehi 2873 3 24 24 CD cord-335975-m6lkrehi 2873 4 men man NNS cord-335975-m6lkrehi 2873 5 and and CC cord-335975-m6lkrehi 2873 6 6 6 CD cord-335975-m6lkrehi 2873 7 women woman NNS cord-335975-m6lkrehi 2873 8 . . . cord-335975-m6lkrehi 2874 1 The the DT cord-335975-m6lkrehi 2874 2 average average NN cord-335975-m6lkrehi 2874 3 burned burn VBN cord-335975-m6lkrehi 2874 4 surface surface NN cord-335975-m6lkrehi 2874 5 area area NN cord-335975-m6lkrehi 2874 6 was be VBD cord-335975-m6lkrehi 2874 7 41 41 CD cord-335975-m6lkrehi 2874 8 ± ± CD cord-335975-m6lkrehi 2874 9 17 17 CD cord-335975-m6lkrehi 2874 10 % % NN cord-335975-m6lkrehi 2874 11 . . . cord-335975-m6lkrehi 2875 1 Patients patient NNS cord-335975-m6lkrehi 2875 2 were be VBD cord-335975-m6lkrehi 2875 3 transferred transfer VBN cord-335975-m6lkrehi 2875 4 from from IN cord-335975-m6lkrehi 2875 5 another another DT cord-335975-m6lkrehi 2875 6 hospital hospital NN cord-335975-m6lkrehi 2875 7 structure structure NN cord-335975-m6lkrehi 2875 8 in in IN cord-335975-m6lkrehi 2875 9 87 87 CD cord-335975-m6lkrehi 2875 10 % % NN cord-335975-m6lkrehi 2875 11 of of IN cord-335975-m6lkrehi 2875 12 cases case NNS cord-335975-m6lkrehi 2875 13 with with IN cord-335975-m6lkrehi 2875 14 a a DT cord-335975-m6lkrehi 2875 15 delay delay NN cord-335975-m6lkrehi 2875 16 of of IN cord-335975-m6lkrehi 2875 17 86 86 CD cord-335975-m6lkrehi 2875 18 h. h. NN cord-335975-m6lkrehi 2876 1 90 90 CD cord-335975-m6lkrehi 2876 2 % % NN cord-335975-m6lkrehi 2876 3 of of IN cord-335975-m6lkrehi 2876 4 patients patient NNS cord-335975-m6lkrehi 2876 5 had have VBD cord-335975-m6lkrehi 2876 6 a a DT cord-335975-m6lkrehi 2876 7 septic septic JJ cord-335975-m6lkrehi 2876 8 complication complication NN cord-335975-m6lkrehi 2876 9 with with IN cord-335975-m6lkrehi 2876 10 a a DT cord-335975-m6lkrehi 2876 11 delay delay NN cord-335975-m6lkrehi 2876 12 of of IN cord-335975-m6lkrehi 2876 13 5 5 CD cord-335975-m6lkrehi 2876 14 ± ± CD cord-335975-m6lkrehi 2876 15 3 3 CD cord-335975-m6lkrehi 2876 16 days day NNS cord-335975-m6lkrehi 2876 17 . . . cord-335975-m6lkrehi 2877 1 Antibiotic antibiotic JJ cord-335975-m6lkrehi 2877 2 treatment treatment NN cord-335975-m6lkrehi 2877 3 was be VBD cord-335975-m6lkrehi 2877 4 empirical empirical JJ cord-335975-m6lkrehi 2877 5 in in IN cord-335975-m6lkrehi 2877 6 23 23 CD cord-335975-m6lkrehi 2877 7 cases case NNS cord-335975-m6lkrehi 2877 8 . . . cord-335975-m6lkrehi 2878 1 The the DT cord-335975-m6lkrehi 2878 2 therapeutic therapeutic JJ cord-335975-m6lkrehi 2878 3 failure failure NN cord-335975-m6lkrehi 2878 4 rate rate NN cord-335975-m6lkrehi 2878 5 was be VBD cord-335975-m6lkrehi 2878 6 60 60 CD cord-335975-m6lkrehi 2878 7 % % NN cord-335975-m6lkrehi 2878 8 . . . cord-335975-m6lkrehi 2879 1 Results result NNS cord-335975-m6lkrehi 2879 2 of of IN cord-335975-m6lkrehi 2879 3 carbame carbame NNP cord-335975-m6lkrehi 2879 4 - - HYPH cord-335975-m6lkrehi 2879 5 nepases nepase NNS cord-335975-m6lkrehi 2879 6 detected detect VBN cord-335975-m6lkrehi 2879 7 by by IN cord-335975-m6lkrehi 2879 8 PCR PCR NNP cord-335975-m6lkrehi 2879 9 are be VBP cord-335975-m6lkrehi 2879 10 detailed detail VBN cord-335975-m6lkrehi 2879 11 in in IN cord-335975-m6lkrehi 2879 12 Table Table NNP cord-335975-m6lkrehi 2879 13 1 1 CD cord-335975-m6lkrehi 2879 14 . . . cord-335975-m6lkrehi 2880 1 In in IN cord-335975-m6lkrehi 2880 2 the the DT cord-335975-m6lkrehi 2880 3 group group NN cord-335975-m6lkrehi 2880 4 of of IN cord-335975-m6lkrehi 2880 5 patients patient NNS cord-335975-m6lkrehi 2880 6 PCR PCR NNP cord-335975-m6lkrehi 2880 7 ( ( -LRB- cord-335975-m6lkrehi 2880 8 + + NNS cord-335975-m6lkrehi 2880 9 ) ) -RRB- cord-335975-m6lkrehi 2880 10 , , , cord-335975-m6lkrehi 2880 11 the the DT cord-335975-m6lkrehi 2880 12 antibiotic antibiotic JJ cord-335975-m6lkrehi 2880 13 treatment treatment NN cord-335975-m6lkrehi 2880 14 was be VBD cord-335975-m6lkrehi 2880 15 changed change VBN cord-335975-m6lkrehi 2880 16 in in IN cord-335975-m6lkrehi 2880 17 18 18 CD cord-335975-m6lkrehi 2880 18 cases case NNS cord-335975-m6lkrehi 2880 19 . . . cord-335975-m6lkrehi 2881 1 The the DT cord-335975-m6lkrehi 2881 2 most most JJS cord-335975-m6lkrehi 2881 3 association association NN cord-335975-m6lkrehi 2881 4 of of IN cord-335975-m6lkrehi 2881 5 antibiotics antibiotic NNS cord-335975-m6lkrehi 2881 6 were be VBD cord-335975-m6lkrehi 2881 7 - - : cord-335975-m6lkrehi 2881 8 tigecycline tigecycline NN cord-335975-m6lkrehi 2881 9 in in IN cord-335975-m6lkrehi 2881 10 combination combination NN cord-335975-m6lkrehi 2881 11 with with IN cord-335975-m6lkrehi 2881 12 colistin colistin NNP cord-335975-m6lkrehi 2881 13 or or CC cord-335975-m6lkrehi 2881 14 in in IN cord-335975-m6lkrehi 2881 15 combination combination NN cord-335975-m6lkrehi 2881 16 with with IN cord-335975-m6lkrehi 2881 17 fosfomycine fosfomycine NN cord-335975-m6lkrehi 2881 18 and and CC cord-335975-m6lkrehi 2881 19 fosfomycin fosfomycin NNS cord-335975-m6lkrehi 2881 20 in in IN cord-335975-m6lkrehi 2881 21 combination combination NN cord-335975-m6lkrehi 2881 22 with with IN cord-335975-m6lkrehi 2881 23 colistin colistin NNP cord-335975-m6lkrehi 2881 24 . . . cord-335975-m6lkrehi 2882 1 This this DT cord-335975-m6lkrehi 2882 2 leads lead VBZ cord-335975-m6lkrehi 2882 3 to to TO cord-335975-m6lkrehi 2882 4 reduce reduce VB cord-335975-m6lkrehi 2882 5 therapeutic therapeutic JJ cord-335975-m6lkrehi 2882 6 failure failure NN cord-335975-m6lkrehi 2882 7 by by IN cord-335975-m6lkrehi 2882 8 20 20 CD cord-335975-m6lkrehi 2882 9 % % NN cord-335975-m6lkrehi 2882 10 . . . cord-335975-m6lkrehi 2883 1 Conclusion conclusion NN cord-335975-m6lkrehi 2883 2 : : : cord-335975-m6lkrehi 2884 1 Detection detection NN cord-335975-m6lkrehi 2884 2 of of IN cord-335975-m6lkrehi 2884 3 carbapenemase carbapenemase NN cord-335975-m6lkrehi 2884 4 in in IN cord-335975-m6lkrehi 2884 5 our -PRON- PRP$ cord-335975-m6lkrehi 2884 6 study study NN cord-335975-m6lkrehi 2884 7 was be VBD cord-335975-m6lkrehi 2884 8 higher high JJR cord-335975-m6lkrehi 2884 9 ( ( -LRB- cord-335975-m6lkrehi 2884 10 80 80 CD cord-335975-m6lkrehi 2884 11 % % NN cord-335975-m6lkrehi 2884 12 ) ) -RRB- cord-335975-m6lkrehi 2884 13 , , , cord-335975-m6lkrehi 2884 14 allows allow VBZ cord-335975-m6lkrehi 2884 15 us -PRON- PRP cord-335975-m6lkrehi 2884 16 to to TO cord-335975-m6lkrehi 2884 17 identify identify VB cord-335975-m6lkrehi 2884 18 regions region NNS cord-335975-m6lkrehi 2884 19 with with IN cord-335975-m6lkrehi 2884 20 high high JJ cord-335975-m6lkrehi 2884 21 risk risk NN cord-335975-m6lkrehi 2884 22 of of IN cord-335975-m6lkrehi 2884 23 carbapenemase carbapenemase NN cord-335975-m6lkrehi 2884 24 , , , cord-335975-m6lkrehi 2884 25 improve improve VB cord-335975-m6lkrehi 2884 26 therapeutic therapeutic JJ cord-335975-m6lkrehi 2884 27 efficacy efficacy NN cord-335975-m6lkrehi 2884 28 and and CC cord-335975-m6lkrehi 2884 29 strengthen strengthen VB cord-335975-m6lkrehi 2884 30 infection infection NN cord-335975-m6lkrehi 2884 31 control control NN cord-335975-m6lkrehi 2884 32 measures measure NNS cord-335975-m6lkrehi 2884 33 by by IN cord-335975-m6lkrehi 2884 34 isolation isolation NN cord-335975-m6lkrehi 2884 35 of of IN cord-335975-m6lkrehi 2884 36 all all DT cord-335975-m6lkrehi 2884 37 carbapenemase carbapenemase NN cord-335975-m6lkrehi 2884 38 producing produce VBG cord-335975-m6lkrehi 2884 39 patient patient NN cord-335975-m6lkrehi 2884 40 . . . cord-335975-m6lkrehi 2885 1 Introduction introduction NN cord-335975-m6lkrehi 2885 2 : : : cord-335975-m6lkrehi 2886 1 ICU ICU NNP cord-335975-m6lkrehi 2886 2 - - HYPH cord-335975-m6lkrehi 2886 3 acquired acquire VBN cord-335975-m6lkrehi 2886 4 bacteraemia bacteraemia NNP cord-335975-m6lkrehi 2886 5 is be VBZ cord-335975-m6lkrehi 2886 6 prevalent prevalent JJ cord-335975-m6lkrehi 2886 7 and and CC cord-335975-m6lkrehi 2886 8 poses pose VBZ cord-335975-m6lkrehi 2886 9 a a DT cord-335975-m6lkrehi 2886 10 grave grave JJ cord-335975-m6lkrehi 2886 11 threat threat NN cord-335975-m6lkrehi 2886 12 . . . cord-335975-m6lkrehi 2887 1 Providing provide VBG cord-335975-m6lkrehi 2887 2 information information NN cord-335975-m6lkrehi 2887 3 about about IN cord-335975-m6lkrehi 2887 4 the the DT cord-335975-m6lkrehi 2887 5 main main JJ cord-335975-m6lkrehi 2887 6 causative causative JJ cord-335975-m6lkrehi 2887 7 bacterial bacterial JJ cord-335975-m6lkrehi 2887 8 agents agent NNS cord-335975-m6lkrehi 2887 9 and and CC cord-335975-m6lkrehi 2887 10 determination determination NN cord-335975-m6lkrehi 2887 11 of of IN cord-335975-m6lkrehi 2887 12 their -PRON- PRP$ cord-335975-m6lkrehi 2887 13 susceptibility susceptibility NN cord-335975-m6lkrehi 2887 14 to to IN cord-335975-m6lkrehi 2887 15 antibiotics antibiotic NNS cord-335975-m6lkrehi 2887 16 may may MD cord-335975-m6lkrehi 2887 17 improve improve VB cord-335975-m6lkrehi 2887 18 empiric empiric JJ cord-335975-m6lkrehi 2887 19 therapy therapy NN cord-335975-m6lkrehi 2887 20 and and CC cord-335975-m6lkrehi 2887 21 early early JJ cord-335975-m6lkrehi 2887 22 detection detection NN cord-335975-m6lkrehi 2887 23 of of IN cord-335975-m6lkrehi 2887 24 emerging emerge VBG cord-335975-m6lkrehi 2887 25 antimicrobial antimicrobial JJ cord-335975-m6lkrehi 2887 26 resistance resistance NN cord-335975-m6lkrehi 2887 27 . . . cord-335975-m6lkrehi 2888 1 The the DT cord-335975-m6lkrehi 2888 2 aim aim NN cord-335975-m6lkrehi 2888 3 of of IN cord-335975-m6lkrehi 2888 4 this this DT cord-335975-m6lkrehi 2888 5 study study NN cord-335975-m6lkrehi 2888 6 was be VBD cord-335975-m6lkrehi 2888 7 to to TO cord-335975-m6lkrehi 2888 8 investigate investigate VB cord-335975-m6lkrehi 2888 9 the the DT cord-335975-m6lkrehi 2888 10 species species NN cord-335975-m6lkrehi 2888 11 distribution distribution NN cord-335975-m6lkrehi 2888 12 and and CC cord-335975-m6lkrehi 2888 13 antibiotic antibiotic JJ cord-335975-m6lkrehi 2888 14 susceptibility susceptibility NN cord-335975-m6lkrehi 2888 15 of of IN cord-335975-m6lkrehi 2888 16 isolated isolated JJ cord-335975-m6lkrehi 2888 17 strains strain NNS cord-335975-m6lkrehi 2888 18 from from IN cord-335975-m6lkrehi 2888 19 blood blood NN cord-335975-m6lkrehi 2888 20 culture culture NN cord-335975-m6lkrehi 2888 21 in in IN cord-335975-m6lkrehi 2888 22 Burn Burn NNP cord-335975-m6lkrehi 2888 23 Intensive Intensive NNP cord-335975-m6lkrehi 2888 24 Care Care NNP cord-335975-m6lkrehi 2888 25 Unit Unit NNP cord-335975-m6lkrehi 2888 26 during during IN cord-335975-m6lkrehi 2888 27 a a DT cord-335975-m6lkrehi 2888 28 five five CD cord-335975-m6lkrehi 2888 29 - - HYPH cord-335975-m6lkrehi 2888 30 year year NN cord-335975-m6lkrehi 2888 31 period period NN cord-335975-m6lkrehi 2888 32 . . . cord-335975-m6lkrehi 2889 1 Patients patient NNS cord-335975-m6lkrehi 2889 2 and and CC cord-335975-m6lkrehi 2889 3 methods method NNS cord-335975-m6lkrehi 2889 4 : : : cord-335975-m6lkrehi 2889 5 From from IN cord-335975-m6lkrehi 2889 6 January January NNP cord-335975-m6lkrehi 2889 7 2012 2012 CD cord-335975-m6lkrehi 2889 8 to to IN cord-335975-m6lkrehi 2889 9 December December NNP cord-335975-m6lkrehi 2889 10 2016 2016 CD cord-335975-m6lkrehi 2889 11 , , , cord-335975-m6lkrehi 2889 12 a a DT cord-335975-m6lkrehi 2889 13 total total NN cord-335975-m6lkrehi 2889 14 of of IN cord-335975-m6lkrehi 2889 15 2,182 2,182 CD cord-335975-m6lkrehi 2889 16 non non JJ cord-335975-m6lkrehi 2889 17 repetitive repetitive JJ cord-335975-m6lkrehi 2889 18 strains strain NNS cord-335975-m6lkrehi 2889 19 were be VBD cord-335975-m6lkrehi 2889 20 isolated isolate VBN cord-335975-m6lkrehi 2889 21 from from IN cord-335975-m6lkrehi 2889 22 blood blood NN cord-335975-m6lkrehi 2889 23 cultures culture NNS cord-335975-m6lkrehi 2889 24 . . . cord-335975-m6lkrehi 2890 1 Incubation incubation NN cord-335975-m6lkrehi 2890 2 of of IN cord-335975-m6lkrehi 2890 3 blood blood NN cord-335975-m6lkrehi 2890 4 culture culture NN cord-335975-m6lkrehi 2890 5 vials vial NNS cord-335975-m6lkrehi 2890 6 and and CC cord-335975-m6lkrehi 2890 7 the the DT cord-335975-m6lkrehi 2890 8 detection detection NN cord-335975-m6lkrehi 2890 9 of of IN cord-335975-m6lkrehi 2890 10 bacterial bacterial JJ cord-335975-m6lkrehi 2890 11 growth growth NN cord-335975-m6lkrehi 2890 12 were be VBD cord-335975-m6lkrehi 2890 13 performed perform VBN cord-335975-m6lkrehi 2890 14 by by IN cord-335975-m6lkrehi 2890 15 the the DT cord-335975-m6lkrehi 2890 16 BACTEC BACTEC NNP cord-335975-m6lkrehi 2890 17 system system NN cord-335975-m6lkrehi 2890 18 . . . cord-335975-m6lkrehi 2891 1 All all DT cord-335975-m6lkrehi 2891 2 Isolated isolate VBN cord-335975-m6lkrehi 2891 3 organisms organism NNS cord-335975-m6lkrehi 2891 4 were be VBD cord-335975-m6lkrehi 2891 5 identified identify VBN cord-335975-m6lkrehi 2891 6 on on IN cord-335975-m6lkrehi 2891 7 the the DT cord-335975-m6lkrehi 2891 8 basis basis NN cord-335975-m6lkrehi 2891 9 of of IN cord-335975-m6lkrehi 2891 10 standard standard JJ cord-335975-m6lkrehi 2891 11 microbiological microbiological JJ cord-335975-m6lkrehi 2891 12 techniques technique NNS cord-335975-m6lkrehi 2891 13 . . . cord-335975-m6lkrehi 2892 1 Antibiotic antibiotic JJ cord-335975-m6lkrehi 2892 2 susceptibility susceptibility NN cord-335975-m6lkrehi 2892 3 testing testing NN cord-335975-m6lkrehi 2892 4 was be VBD cord-335975-m6lkrehi 2892 5 carried carry VBN cord-335975-m6lkrehi 2892 6 out out RP cord-335975-m6lkrehi 2892 7 by by IN cord-335975-m6lkrehi 2892 8 the the DT cord-335975-m6lkrehi 2892 9 agar agar NNP cord-335975-m6lkrehi 2892 10 disk disk NN cord-335975-m6lkrehi 2892 11 diffusion diffusion NN cord-335975-m6lkrehi 2892 12 method method NN cord-335975-m6lkrehi 2892 13 , , , cord-335975-m6lkrehi 2892 14 and and CC cord-335975-m6lkrehi 2892 15 susceptibility susceptibility NN cord-335975-m6lkrehi 2892 16 results result NNS cord-335975-m6lkrehi 2892 17 were be VBD cord-335975-m6lkrehi 2892 18 interpreted interpret VBN cord-335975-m6lkrehi 2892 19 using use VBG cord-335975-m6lkrehi 2892 20 clinical clinical JJ cord-335975-m6lkrehi 2892 21 breakpoints breakpoint NNS cord-335975-m6lkrehi 2892 22 according accord VBG cord-335975-m6lkrehi 2892 23 to to IN cord-335975-m6lkrehi 2892 24 CA CA NNP cord-335975-m6lkrehi 2892 25 - - HYPH cord-335975-m6lkrehi 2892 26 SFM SFM NNP cord-335975-m6lkrehi 2892 27 2013 2013 CD cord-335975-m6lkrehi 2892 28 and and CC cord-335975-m6lkrehi 2892 29 2015 2015 CD cord-335975-m6lkrehi 2892 30 guidelines guideline NNS cord-335975-m6lkrehi 2892 31 . . . cord-335975-m6lkrehi 2893 1 Data datum NNS cord-335975-m6lkrehi 2893 2 were be VBD cord-335975-m6lkrehi 2893 3 analyzed analyze VBN cord-335975-m6lkrehi 2893 4 using use VBG cord-335975-m6lkrehi 2893 5 the the DT cord-335975-m6lkrehi 2893 6 SIR SIR NNP cord-335975-m6lkrehi 2893 7 - - HYPH cord-335975-m6lkrehi 2893 8 system system NN cord-335975-m6lkrehi 2893 9 . . . cord-335975-m6lkrehi 2894 1 Minimum minimum JJ cord-335975-m6lkrehi 2894 2 inhibitory inhibitory JJ cord-335975-m6lkrehi 2894 3 concentrations concentration NNS cord-335975-m6lkrehi 2894 4 of of IN cord-335975-m6lkrehi 2894 5 colistin colistin NNP cord-335975-m6lkrehi 2894 6 , , , cord-335975-m6lkrehi 2894 7 imipenem imipenem NNP cord-335975-m6lkrehi 2894 8 and and CC cord-335975-m6lkrehi 2894 9 vancomycin vancomycin NNS cord-335975-m6lkrehi 2894 10 were be VBD cord-335975-m6lkrehi 2894 11 determined determine VBN cord-335975-m6lkrehi 2894 12 using use VBG cord-335975-m6lkrehi 2894 13 the the DT cord-335975-m6lkrehi 2894 14 Etest Etest NNP cord-335975-m6lkrehi 2894 15 ® ® NN cord-335975-m6lkrehi 2894 16 method method NN cord-335975-m6lkrehi 2894 17 ( ( -LRB- cord-335975-m6lkrehi 2894 18 bioMérieux bioMérieux NNP cord-335975-m6lkrehi 2894 19 ) ) -RRB- cord-335975-m6lkrehi 2894 20 . . . cord-335975-m6lkrehi 2895 1 Results result NNS cord-335975-m6lkrehi 2895 2 : : : cord-335975-m6lkrehi 2896 1 Of of IN cord-335975-m6lkrehi 2896 2 the the DT cord-335975-m6lkrehi 2896 3 2,182 2,182 CD cord-335975-m6lkrehi 2896 4 strains strain NNS cord-335975-m6lkrehi 2896 5 isolated isolate VBN cord-335975-m6lkrehi 2896 6 , , , cord-335975-m6lkrehi 2896 7 the the DT cord-335975-m6lkrehi 2896 8 most most RBS cord-335975-m6lkrehi 2896 9 frequently frequently RB cord-335975-m6lkrehi 2896 10 identified identify VBN cord-335975-m6lkrehi 2896 11 species specie NNS cord-335975-m6lkrehi 2896 12 were be VBD cord-335975-m6lkrehi 2896 13 Staphylococcus Staphylococcus NNP cord-335975-m6lkrehi 2896 14 aureus aureus NN cord-335975-m6lkrehi 2896 15 ( ( -LRB- cord-335975-m6lkrehi 2896 16 21 21 CD cord-335975-m6lkrehi 2896 17 % % NN cord-335975-m6lkrehi 2896 18 ) ) -RRB- cord-335975-m6lkrehi 2896 19 , , , cord-335975-m6lkrehi 2896 20 Acinetobacter Acinetobacter NNP cord-335975-m6lkrehi 2896 21 baumannii baumannii NNP cord-335975-m6lkrehi 2896 22 ( ( -LRB- cord-335975-m6lkrehi 2896 23 11 11 CD cord-335975-m6lkrehi 2896 24 % % NN cord-335975-m6lkrehi 2896 25 ) ) -RRB- cord-335975-m6lkrehi 2896 26 , , , cord-335975-m6lkrehi 2896 27 Klebsiella Klebsiella NNP cord-335975-m6lkrehi 2896 28 pneumoniae pneumoniae NN cord-335975-m6lkrehi 2896 29 ( ( -LRB- cord-335975-m6lkrehi 2896 30 10 10 CD cord-335975-m6lkrehi 2896 31 % % NN cord-335975-m6lkrehi 2896 32 ) ) -RRB- cord-335975-m6lkrehi 2896 33 , , , cord-335975-m6lkrehi 2896 34 and and CC cord-335975-m6lkrehi 2896 35 Pseudomonas Pseudomonas NNP cord-335975-m6lkrehi 2896 36 aeruginosa aeruginosa NN cord-335975-m6lkrehi 2896 37 ( ( -LRB- cord-335975-m6lkrehi 2896 38 9 9 CD cord-335975-m6lkrehi 2896 39 % % NN cord-335975-m6lkrehi 2896 40 ) ) -RRB- cord-335975-m6lkrehi 2896 41 . . . cord-335975-m6lkrehi 2897 1 The the DT cord-335975-m6lkrehi 2897 2 rate rate NN cord-335975-m6lkrehi 2897 3 of of IN cord-335975-m6lkrehi 2897 4 methicillin methicillin NN cord-335975-m6lkrehi 2897 5 - - HYPH cord-335975-m6lkrehi 2897 6 resistant resistant JJ cord-335975-m6lkrehi 2897 7 Staphylococcus Staphylococcus NNP cord-335975-m6lkrehi 2897 8 aureus aureus NN cord-335975-m6lkrehi 2897 9 ( ( -LRB- cord-335975-m6lkrehi 2897 10 MRSA MRSA NNP cord-335975-m6lkrehi 2897 11 ) ) -RRB- cord-335975-m6lkrehi 2897 12 was be VBD cord-335975-m6lkrehi 2897 13 70 70 CD cord-335975-m6lkrehi 2897 14 % % NN cord-335975-m6lkrehi 2897 15 . . . cord-335975-m6lkrehi 2898 1 Resistance resistance NN cord-335975-m6lkrehi 2898 2 to to IN cord-335975-m6lkrehi 2898 3 tigecycline tigecycline NN cord-335975-m6lkrehi 2898 4 and and CC cord-335975-m6lkrehi 2898 5 linezolid linezolid NNP cord-335975-m6lkrehi 2898 6 was be VBD cord-335975-m6lkrehi 2898 7 15 15 CD cord-335975-m6lkrehi 2898 8 and and CC cord-335975-m6lkrehi 2898 9 1 1 CD cord-335975-m6lkrehi 2898 10 % % NN cord-335975-m6lkrehi 2898 11 , , , cord-335975-m6lkrehi 2898 12 respectively respectively RB cord-335975-m6lkrehi 2898 13 . . . cord-335975-m6lkrehi 2899 1 All all DT cord-335975-m6lkrehi 2899 2 strains strain NNS cord-335975-m6lkrehi 2899 3 were be VBD cord-335975-m6lkrehi 2899 4 susceptible susceptible JJ cord-335975-m6lkrehi 2899 5 to to IN cord-335975-m6lkrehi 2899 6 glycopeptides glycopeptide NNS cord-335975-m6lkrehi 2899 7 . . . cord-335975-m6lkrehi 2900 1 In in IN cord-335975-m6lkrehi 2900 2 addition addition NN cord-335975-m6lkrehi 2900 3 , , , cord-335975-m6lkrehi 2900 4 isolated isolate VBN cord-335975-m6lkrehi 2900 5 Acinetobacter Acinetobacter NNP cord-335975-m6lkrehi 2900 6 baumanii baumanii JJ cord-335975-m6lkrehi 2900 7 strains strain NNS cord-335975-m6lkrehi 2900 8 showed show VBD cord-335975-m6lkrehi 2900 9 high high JJ cord-335975-m6lkrehi 2900 10 rates rate NNS cord-335975-m6lkrehi 2900 11 of of IN cord-335975-m6lkrehi 2900 12 resistant resistant JJ cord-335975-m6lkrehi 2900 13 to to IN cord-335975-m6lkrehi 2900 14 all all DT cord-335975-m6lkrehi 2900 15 tested test VBN cord-335975-m6lkrehi 2900 16 antibiotics antibiotic NNS cord-335975-m6lkrehi 2900 17 except except IN cord-335975-m6lkrehi 2900 18 colistin colistin NNP cord-335975-m6lkrehi 2900 19 . . . cord-335975-m6lkrehi 2901 1 Eighty eighty CD cord-335975-m6lkrehi 2901 2 per per IN cord-335975-m6lkrehi 2901 3 cent cent NN cord-335975-m6lkrehi 2901 4 of of IN cord-335975-m6lkrehi 2901 5 these these DT cord-335975-m6lkrehi 2901 6 strains strain NNS cord-335975-m6lkrehi 2901 7 were be VBD cord-335975-m6lkrehi 2901 8 resistant resistant JJ cord-335975-m6lkrehi 2901 9 to to IN cord-335975-m6lkrehi 2901 10 ceftazidime ceftazidime NN cord-335975-m6lkrehi 2901 11 and and CC cord-335975-m6lkrehi 2901 12 94 94 CD cord-335975-m6lkrehi 2901 13 % % NN cord-335975-m6lkrehi 2901 14 to to IN cord-335975-m6lkrehi 2901 15 imipenem imipenem NNP cord-335975-m6lkrehi 2901 16 . . . cord-335975-m6lkrehi 2902 1 Resistance resistance NN cord-335975-m6lkrehi 2902 2 to to IN cord-335975-m6lkrehi 2902 3 rifampicin rifampicin NNS cord-335975-m6lkrehi 2902 4 was be VBD cord-335975-m6lkrehi 2902 5 15 15 CD cord-335975-m6lkrehi 2902 6 % % NN cord-335975-m6lkrehi 2902 7 in in IN cord-335975-m6lkrehi 2902 8 2014 2014 CD cord-335975-m6lkrehi 2902 9 , , , cord-335975-m6lkrehi 2902 10 and and CC cord-335975-m6lkrehi 2902 11 has have VBZ cord-335975-m6lkrehi 2902 12 increased increase VBN cord-335975-m6lkrehi 2902 13 steadily steadily RB cord-335975-m6lkrehi 2902 14 to to IN cord-335975-m6lkrehi 2902 15 67 67 CD cord-335975-m6lkrehi 2902 16 % % NN cord-335975-m6lkrehi 2902 17 by by IN cord-335975-m6lkrehi 2902 18 2016 2016 CD cord-335975-m6lkrehi 2902 19 . . . cord-335975-m6lkrehi 2903 1 Similarly similarly RB cord-335975-m6lkrehi 2903 2 , , , cord-335975-m6lkrehi 2903 3 high high JJ cord-335975-m6lkrehi 2903 4 resistance resistance NN cord-335975-m6lkrehi 2903 5 rates rate NNS cord-335975-m6lkrehi 2903 6 were be VBD cord-335975-m6lkrehi 2903 7 observed observe VBN cord-335975-m6lkrehi 2903 8 among among IN cord-335975-m6lkrehi 2903 9 Klebsiella Klebsiella NNP cord-335975-m6lkrehi 2903 10 pneumoniae pneumoniae NN cord-335975-m6lkrehi 2903 11 and and CC cord-335975-m6lkrehi 2903 12 Pseudomonas Pseudomonas NNP cord-335975-m6lkrehi 2903 13 aeruginosa aeruginosa VBZ cord-335975-m6lkrehi 2903 14 to to IN cord-335975-m6lkrehi 2903 15 ceftazidime ceftazidime NNP cord-335975-m6lkrehi 2903 16 ( ( -LRB- cord-335975-m6lkrehi 2903 17 70 70 CD cord-335975-m6lkrehi 2903 18 and and CC cord-335975-m6lkrehi 2903 19 39 39 CD cord-335975-m6lkrehi 2903 20 % % NN cord-335975-m6lkrehi 2903 21 respectively respectively RB cord-335975-m6lkrehi 2903 22 ) ) -RRB- cord-335975-m6lkrehi 2903 23 , , , cord-335975-m6lkrehi 2903 24 ciprofloxacin ciprofloxacin NNP cord-335975-m6lkrehi 2903 25 ( ( -LRB- cord-335975-m6lkrehi 2903 26 68 68 CD cord-335975-m6lkrehi 2903 27 and and CC cord-335975-m6lkrehi 2903 28 67 67 CD cord-335975-m6lkrehi 2903 29 % % NN cord-335975-m6lkrehi 2903 30 ) ) -RRB- cord-335975-m6lkrehi 2903 31 and and CC cord-335975-m6lkrehi 2903 32 imipenem imipenem NNP cord-335975-m6lkrehi 2903 33 ( ( -LRB- cord-335975-m6lkrehi 2903 34 15 15 CD cord-335975-m6lkrehi 2903 35 and and CC cord-335975-m6lkrehi 2903 36 72 72 CD cord-335975-m6lkrehi 2903 37 % % NN cord-335975-m6lkrehi 2903 38 ) ) -RRB- cord-335975-m6lkrehi 2903 39 . . . cord-335975-m6lkrehi 2904 1 Conclusion conclusion NN cord-335975-m6lkrehi 2904 2 : : : cord-335975-m6lkrehi 2905 1 This this DT cord-335975-m6lkrehi 2905 2 study study NN cord-335975-m6lkrehi 2905 3 investigated investigate VBD cord-335975-m6lkrehi 2905 4 on on IN cord-335975-m6lkrehi 2905 5 the the DT cord-335975-m6lkrehi 2905 6 local local JJ cord-335975-m6lkrehi 2905 7 distribution distribution NN cord-335975-m6lkrehi 2905 8 patterns pattern NNS cord-335975-m6lkrehi 2905 9 of of IN cord-335975-m6lkrehi 2905 10 causative causative JJ cord-335975-m6lkrehi 2905 11 organisms organism NNS cord-335975-m6lkrehi 2905 12 of of IN cord-335975-m6lkrehi 2905 13 bacteraemia bacteraemia NN cord-335975-m6lkrehi 2905 14 in in IN cord-335975-m6lkrehi 2905 15 burn burn NN cord-335975-m6lkrehi 2905 16 patients patient NNS cord-335975-m6lkrehi 2905 17 and and CC cord-335975-m6lkrehi 2905 18 the the DT cord-335975-m6lkrehi 2905 19 corresponding corresponding JJ cord-335975-m6lkrehi 2905 20 antimicrobial antimicrobial JJ cord-335975-m6lkrehi 2905 21 susceptibility susceptibility NN cord-335975-m6lkrehi 2905 22 profiles profile NNS cord-335975-m6lkrehi 2905 23 . . . cord-335975-m6lkrehi 2906 1 Multidrug multidrug JJ cord-335975-m6lkrehi 2906 2 - - HYPH cord-335975-m6lkrehi 2906 3 resistant resistant JJ cord-335975-m6lkrehi 2906 4 pathogens pathogen NNS cord-335975-m6lkrehi 2906 5 , , , cord-335975-m6lkrehi 2906 6 especially especially RB cord-335975-m6lkrehi 2906 7 MRSA MRSA NNP cord-335975-m6lkrehi 2906 8 and and CC cord-335975-m6lkrehi 2906 9 Acinetobacter Acinetobacter NNP cord-335975-m6lkrehi 2906 10 baumanii baumanii NNP cord-335975-m6lkrehi 2906 11 , , , cord-335975-m6lkrehi 2906 12 were be VBD cord-335975-m6lkrehi 2906 13 the the DT cord-335975-m6lkrehi 2906 14 most most RBS cord-335975-m6lkrehi 2906 15 frequently frequently RB cord-335975-m6lkrehi 2906 16 isolated isolate VBN cord-335975-m6lkrehi 2906 17 organisms organism NNS cord-335975-m6lkrehi 2906 18 . . . cord-335975-m6lkrehi 2907 1 Hygiene hygiene NN cord-335975-m6lkrehi 2907 2 measures measure NNS cord-335975-m6lkrehi 2907 3 and and CC cord-335975-m6lkrehi 2907 4 antimicrobial antimicrobial JJ cord-335975-m6lkrehi 2907 5 stewardship stewardship NN cord-335975-m6lkrehi 2907 6 should should MD cord-335975-m6lkrehi 2907 7 be be VB cord-335975-m6lkrehi 2907 8 implemented implement VBN cord-335975-m6lkrehi 2907 9 to to TO cord-335975-m6lkrehi 2907 10 prevent prevent VB cord-335975-m6lkrehi 2907 11 the the DT cord-335975-m6lkrehi 2907 12 spreading spreading NN cord-335975-m6lkrehi 2907 13 of of IN cord-335975-m6lkrehi 2907 14 these these DT cord-335975-m6lkrehi 2907 15 resistant resistant JJ cord-335975-m6lkrehi 2907 16 strains strain NNS cord-335975-m6lkrehi 2907 17 . . . cord-335975-m6lkrehi 2908 1 Introduction introduction NN cord-335975-m6lkrehi 2908 2 : : : cord-335975-m6lkrehi 2909 1 Pseudomonas Pseudomonas NNP cord-335975-m6lkrehi 2909 2 aeruginosa aeruginosa NN cord-335975-m6lkrehi 2909 3 is be VBZ cord-335975-m6lkrehi 2909 4 known know VBN cord-335975-m6lkrehi 2909 5 opportunistic opportunistic JJ cord-335975-m6lkrehi 2909 6 pathogen pathogen NN cord-335975-m6lkrehi 2909 7 frequently frequently RB cord-335975-m6lkrehi 2909 8 causing cause VBG cord-335975-m6lkrehi 2909 9 serious serious JJ cord-335975-m6lkrehi 2909 10 infections infection NNS cord-335975-m6lkrehi 2909 11 in in IN cord-335975-m6lkrehi 2909 12 burned burn VBN cord-335975-m6lkrehi 2909 13 patients patient NNS cord-335975-m6lkrehi 2909 14 . . . cord-335975-m6lkrehi 2910 1 Multidrug multidrug JJ cord-335975-m6lkrehi 2910 2 resistance resistance NN cord-335975-m6lkrehi 2910 3 in in IN cord-335975-m6lkrehi 2910 4 this this DT cord-335975-m6lkrehi 2910 5 pathogen pathogen NN cord-335975-m6lkrehi 2910 6 is be VBZ cord-335975-m6lkrehi 2910 7 increasing increase VBG cord-335975-m6lkrehi 2910 8 throughout throughout IN cord-335975-m6lkrehi 2910 9 the the DT cord-335975-m6lkrehi 2910 10 world world NN cord-335975-m6lkrehi 2910 11 and and CC cord-335975-m6lkrehi 2910 12 is be VBZ cord-335975-m6lkrehi 2910 13 a a DT cord-335975-m6lkrehi 2910 14 major major JJ cord-335975-m6lkrehi 2910 15 problem problem NN cord-335975-m6lkrehi 2910 16 in in IN cord-335975-m6lkrehi 2910 17 the the DT cord-335975-m6lkrehi 2910 18 management management NN cord-335975-m6lkrehi 2910 19 of of IN cord-335975-m6lkrehi 2910 20 these these DT cord-335975-m6lkrehi 2910 21 pathogens pathogen NNS cord-335975-m6lkrehi 2910 22 . . . cord-335975-m6lkrehi 2911 1 Analysis analysis NN cord-335975-m6lkrehi 2911 2 of of IN cord-335975-m6lkrehi 2911 3 serotype serotype NN cord-335975-m6lkrehi 2911 4 and and CC cord-335975-m6lkrehi 2911 5 resistance resistance NN cord-335975-m6lkrehi 2911 6 profile profile NN cord-335975-m6lkrehi 2911 7 to to IN cord-335975-m6lkrehi 2911 8 antobiotics antobiotic NNS cord-335975-m6lkrehi 2911 9 of of IN cord-335975-m6lkrehi 2911 10 P. P. NNP cord-335975-m6lkrehi 2911 11 aeruginosa aeruginosa NN cord-335975-m6lkrehi 2911 12 help help NN cord-335975-m6lkrehi 2911 13 to to TO cord-335975-m6lkrehi 2911 14 establish establish VB cord-335975-m6lkrehi 2911 15 a a DT cord-335975-m6lkrehi 2911 16 prompt prompt JJ cord-335975-m6lkrehi 2911 17 control control NN cord-335975-m6lkrehi 2911 18 and and CC cord-335975-m6lkrehi 2911 19 prevention prevention NN cord-335975-m6lkrehi 2911 20 program program NN cord-335975-m6lkrehi 2911 21 . . . cord-335975-m6lkrehi 2912 1 The the DT cord-335975-m6lkrehi 2912 2 aim aim NN cord-335975-m6lkrehi 2912 3 of of IN cord-335975-m6lkrehi 2912 4 this this DT cord-335975-m6lkrehi 2912 5 study study NN cord-335975-m6lkrehi 2912 6 was be VBD cord-335975-m6lkrehi 2912 7 to to TO cord-335975-m6lkrehi 2912 8 evaluate evaluate VB cord-335975-m6lkrehi 2912 9 the the DT cord-335975-m6lkrehi 2912 10 frequency frequency NN cord-335975-m6lkrehi 2912 11 of of IN cord-335975-m6lkrehi 2912 12 antimicrobial antimicrobial JJ cord-335975-m6lkrehi 2912 13 resistance resistance NN cord-335975-m6lkrehi 2912 14 and and CC cord-335975-m6lkrehi 2912 15 the the DT cord-335975-m6lkrehi 2912 16 prevalence prevalence NN cord-335975-m6lkrehi 2912 17 of of IN cord-335975-m6lkrehi 2912 18 Pseudomonas Pseudomonas NNP cord-335975-m6lkrehi 2912 19 aeruginosa aeruginosa NN cord-335975-m6lkrehi 2912 20 serotypes serotype NNS cord-335975-m6lkrehi 2912 21 isolated isolate VBN cord-335975-m6lkrehi 2912 22 in in IN cord-335975-m6lkrehi 2912 23 the the DT cord-335975-m6lkrehi 2912 24 burn burn NN cord-335975-m6lkrehi 2912 25 unit unit NN cord-335975-m6lkrehi 2912 26 . . . cord-335975-m6lkrehi 2913 1 Patients patient NNS cord-335975-m6lkrehi 2913 2 and and CC cord-335975-m6lkrehi 2913 3 methods method NNS cord-335975-m6lkrehi 2913 4 : : : cord-335975-m6lkrehi 2913 5 During during IN cord-335975-m6lkrehi 2913 6 a a DT cord-335975-m6lkrehi 2913 7 period period NN cord-335975-m6lkrehi 2913 8 of of IN cord-335975-m6lkrehi 2913 9 4 4 CD cord-335975-m6lkrehi 2913 10 years year NNS cord-335975-m6lkrehi 2913 11 ( ( -LRB- cord-335975-m6lkrehi 2913 12 from from IN cord-335975-m6lkrehi 2913 13 01 01 CD cord-335975-m6lkrehi 2913 14 01 01 CD cord-335975-m6lkrehi 2913 15 2012 2012 CD cord-335975-m6lkrehi 2913 16 to to IN cord-335975-m6lkrehi 2913 17 31 31 CD cord-335975-m6lkrehi 2913 18 12 12 CD cord-335975-m6lkrehi 2913 19 2015 2015 CD cord-335975-m6lkrehi 2913 20 ) ) -RRB- cord-335975-m6lkrehi 2913 21 , , , cord-335975-m6lkrehi 2913 22 485 485 CD cord-335975-m6lkrehi 2913 23 strains strain NNS cord-335975-m6lkrehi 2913 24 of of IN cord-335975-m6lkrehi 2913 25 Pseudomonas Pseudomonas NNP cord-335975-m6lkrehi 2913 26 aeruginosa aeruginosa NN cord-335975-m6lkrehi 2913 27 were be VBD cord-335975-m6lkrehi 2913 28 isolated isolate VBN cord-335975-m6lkrehi 2913 29 from from IN cord-335975-m6lkrehi 2913 30 burned burn VBN cord-335975-m6lkrehi 2913 31 patients patient NNS cord-335975-m6lkrehi 2913 32 . . . cord-335975-m6lkrehi 2914 1 Conventional conventional JJ cord-335975-m6lkrehi 2914 2 methods method NNS cord-335975-m6lkrehi 2914 3 were be VBD cord-335975-m6lkrehi 2914 4 used use VBN cord-335975-m6lkrehi 2914 5 for for IN cord-335975-m6lkrehi 2914 6 identification identification NN cord-335975-m6lkrehi 2914 7 . . . cord-335975-m6lkrehi 2915 1 Antimicrobial antimicrobial JJ cord-335975-m6lkrehi 2915 2 susceptibility susceptibility NN cord-335975-m6lkrehi 2915 3 testing testing NN cord-335975-m6lkrehi 2915 4 was be VBD cord-335975-m6lkrehi 2915 5 performed perform VBN cord-335975-m6lkrehi 2915 6 with with IN cord-335975-m6lkrehi 2915 7 disk disk NN cord-335975-m6lkrehi 2915 8 diffusion diffusion NN cord-335975-m6lkrehi 2915 9 method method NN cord-335975-m6lkrehi 2915 10 and and CC cord-335975-m6lkrehi 2915 11 susceptibility susceptibility NN cord-335975-m6lkrehi 2915 12 data datum NNS cord-335975-m6lkrehi 2915 13 were be VBD cord-335975-m6lkrehi 2915 14 interpreted interpret VBN cord-335975-m6lkrehi 2915 15 according accord VBG cord-335975-m6lkrehi 2915 16 to to IN cord-335975-m6lkrehi 2915 17 breakpoints breakpoint NNS cord-335975-m6lkrehi 2915 18 recommended recommend VBN cord-335975-m6lkrehi 2915 19 by by IN cord-335975-m6lkrehi 2915 20 the the DT cord-335975-m6lkrehi 2915 21 French French NNP cord-335975-m6lkrehi 2915 22 Society Society NNP cord-335975-m6lkrehi 2915 23 of of IN cord-335975-m6lkrehi 2915 24 Microbiology Microbiology NNP cord-335975-m6lkrehi 2915 25 ( ( -LRB- cord-335975-m6lkrehi 2915 26 FSM FSM NNP cord-335975-m6lkrehi 2915 27 ) ) -RRB- cord-335975-m6lkrehi 2915 28 . . . cord-335975-m6lkrehi 2916 1 Serotypes serotype NNS cord-335975-m6lkrehi 2916 2 were be VBD cord-335975-m6lkrehi 2916 3 identified identify VBN cord-335975-m6lkrehi 2916 4 by by IN cord-335975-m6lkrehi 2916 5 slide slide NN cord-335975-m6lkrehi 2916 6 agglutination agglutination NN cord-335975-m6lkrehi 2916 7 test test NN cord-335975-m6lkrehi 2916 8 using use VBG cord-335975-m6lkrehi 2916 9 P. P. NNP cord-335975-m6lkrehi 2916 10 aeruginosa aeruginosa NNP cord-335975-m6lkrehi 2916 11 O o NN cord-335975-m6lkrehi 2916 12 antisera antisera NN cord-335975-m6lkrehi 2916 13 ( ( -LRB- cord-335975-m6lkrehi 2916 14 Biorad Biorad NNP cord-335975-m6lkrehi 2916 15 ) ) -RRB- cord-335975-m6lkrehi 2916 16 . . . cord-335975-m6lkrehi 2917 1 The the DT cord-335975-m6lkrehi 2917 2 imipenem imipenem JJ cord-335975-m6lkrehi 2917 3 - - HYPH cord-335975-m6lkrehi 2917 4 resistant resistant JJ cord-335975-m6lkrehi 2917 5 strains strain NNS cord-335975-m6lkrehi 2917 6 have have VBP cord-335975-m6lkrehi 2917 7 benefited benefit VBN cord-335975-m6lkrehi 2917 8 from from IN cord-335975-m6lkrehi 2917 9 a a DT cord-335975-m6lkrehi 2917 10 research research NN cord-335975-m6lkrehi 2917 11 of of IN cord-335975-m6lkrehi 2917 12 carbapenemase carbapenemase NN cord-335975-m6lkrehi 2917 13 production production NN cord-335975-m6lkrehi 2917 14 by by IN cord-335975-m6lkrehi 2917 15 the the DT cord-335975-m6lkrehi 2917 16 EDTA EDTA NNP cord-335975-m6lkrehi 2917 17 test test NN cord-335975-m6lkrehi 2917 18 . . . cord-335975-m6lkrehi 2918 1 Results result NNS cord-335975-m6lkrehi 2918 2 : : : cord-335975-m6lkrehi 2919 1 In in IN cord-335975-m6lkrehi 2919 2 our -PRON- PRP$ cord-335975-m6lkrehi 2919 3 study study NN cord-335975-m6lkrehi 2919 4 period period NN cord-335975-m6lkrehi 2919 5 , , , cord-335975-m6lkrehi 2919 6 3464 3464 CD cord-335975-m6lkrehi 2919 7 bacterial bacterial JJ cord-335975-m6lkrehi 2919 8 isolates isolate NNS cord-335975-m6lkrehi 2919 9 were be VBD cord-335975-m6lkrehi 2919 10 found find VBN cord-335975-m6lkrehi 2919 11 among among IN cord-335975-m6lkrehi 2919 12 which which WDT cord-335975-m6lkrehi 2919 13 Pseudomonas Pseudomonas NNP cord-335975-m6lkrehi 2919 14 aeruginosa aeruginosa NN cord-335975-m6lkrehi 2919 15 was be VBD cord-335975-m6lkrehi 2919 16 the the DT cord-335975-m6lkrehi 2919 17 second second JJ cord-335975-m6lkrehi 2919 18 most most RBS cord-335975-m6lkrehi 2919 19 frequent frequent JJ cord-335975-m6lkrehi 2919 20 bacterium bacterium NN cord-335975-m6lkrehi 2919 21 isolated isolate VBN cord-335975-m6lkrehi 2919 22 from from IN cord-335975-m6lkrehi 2919 23 burned burn VBN cord-335975-m6lkrehi 2919 24 patients patient NNS cord-335975-m6lkrehi 2919 25 ( ( -LRB- cord-335975-m6lkrehi 2919 26 14 14 CD cord-335975-m6lkrehi 2919 27 % % NN cord-335975-m6lkrehi 2919 28 ) ) -RRB- cord-335975-m6lkrehi 2919 29 after after IN cord-335975-m6lkrehi 2919 30 Staphylococcus Staphylococcus NNP cord-335975-m6lkrehi 2919 31 aureus aureus NN cord-335975-m6lkrehi 2919 32 ( ( -LRB- cord-335975-m6lkrehi 2919 33 18 18 CD cord-335975-m6lkrehi 2919 34 % % NN cord-335975-m6lkrehi 2919 35 ) ) -RRB- cord-335975-m6lkrehi 2919 36 . . . cord-335975-m6lkrehi 2920 1 The the DT cord-335975-m6lkrehi 2920 2 most most RBS cord-335975-m6lkrehi 2920 3 frequent frequent JJ cord-335975-m6lkrehi 2920 4 sites site NNS cord-335975-m6lkrehi 2920 5 were be VBD cord-335975-m6lkrehi 2920 6 - - HYPH cord-335975-m6lkrehi 2920 7 cutaneus cutaneus NN cord-335975-m6lkrehi 2920 8 infection infection NN cord-335975-m6lkrehi 2920 9 ( ( -LRB- cord-335975-m6lkrehi 2920 10 36 36 CD cord-335975-m6lkrehi 2920 11 % % NN cord-335975-m6lkrehi 2920 12 ) ) -RRB- cord-335975-m6lkrehi 2920 13 , , , cord-335975-m6lkrehi 2920 14 blood blood NN cord-335975-m6lkrehi 2920 15 culture culture NN cord-335975-m6lkrehi 2920 16 ( ( -LRB- cord-335975-m6lkrehi 2920 17 24 24 CD cord-335975-m6lkrehi 2920 18 % % NN cord-335975-m6lkrehi 2920 19 ) ) -RRB- cord-335975-m6lkrehi 2920 20 and and CC cord-335975-m6lkrehi 2920 21 catheter catheter NN cord-335975-m6lkrehi 2920 22 ( ( -LRB- cord-335975-m6lkrehi 2920 23 16 16 CD cord-335975-m6lkrehi 2920 24 % % NN cord-335975-m6lkrehi 2920 25 ) ) -RRB- cord-335975-m6lkrehi 2920 26 . . . cord-335975-m6lkrehi 2921 1 The the DT cord-335975-m6lkrehi 2921 2 most most RBS cord-335975-m6lkrehi 2921 3 prevalent prevalent JJ cord-335975-m6lkrehi 2921 4 serotypes serotype NNS cord-335975-m6lkrehi 2921 5 were be VBD cord-335975-m6lkrehi 2921 6 - - : cord-335975-m6lkrehi 2921 7 O12 O12 NNP cord-335975-m6lkrehi 2921 8 ( ( -LRB- cord-335975-m6lkrehi 2921 9 72 72 CD cord-335975-m6lkrehi 2921 10 % % NN cord-335975-m6lkrehi 2921 11 ) ) -RRB- cord-335975-m6lkrehi 2921 12 , , , cord-335975-m6lkrehi 2921 13 O1 o1 NN cord-335975-m6lkrehi 2921 14 ( ( -LRB- cord-335975-m6lkrehi 2921 15 10 10 CD cord-335975-m6lkrehi 2921 16 % % NN cord-335975-m6lkrehi 2921 17 ) ) -RRB- cord-335975-m6lkrehi 2921 18 , , , cord-335975-m6lkrehi 2921 19 O2 O2 NNP cord-335975-m6lkrehi 2921 20 ( ( -LRB- cord-335975-m6lkrehi 2921 21 6 6 CD cord-335975-m6lkrehi 2921 22 % % NN cord-335975-m6lkrehi 2921 23 ) ) -RRB- cord-335975-m6lkrehi 2921 24 , , , cord-335975-m6lkrehi 2921 25 O11 O11 NNP cord-335975-m6lkrehi 2921 26 ( ( -LRB- cord-335975-m6lkrehi 2921 27 1 1 CD cord-335975-m6lkrehi 2921 28 % % NN cord-335975-m6lkrehi 2921 29 ) ) -RRB- cord-335975-m6lkrehi 2921 30 and and CC cord-335975-m6lkrehi 2921 31 O6 O6 NNP cord-335975-m6lkrehi 2921 32 ( ( -LRB- cord-335975-m6lkrehi 2921 33 1 1 CD cord-335975-m6lkrehi 2921 34 % % NN cord-335975-m6lkrehi 2921 35 ) ) -RRB- cord-335975-m6lkrehi 2921 36 . . . cord-335975-m6lkrehi 2922 1 The the DT cord-335975-m6lkrehi 2922 2 survey survey NN cord-335975-m6lkrehi 2922 3 of of IN cord-335975-m6lkrehi 2922 4 antibiotic antibiotic JJ cord-335975-m6lkrehi 2922 5 susceptibilily susceptibilily NNP cord-335975-m6lkrehi 2922 6 showed show VBD cord-335975-m6lkrehi 2922 7 high high JJ cord-335975-m6lkrehi 2922 8 pourcentage pourcentage NN cord-335975-m6lkrehi 2922 9 of of IN cord-335975-m6lkrehi 2922 10 resistance resistance NN cord-335975-m6lkrehi 2922 11 to to IN cord-335975-m6lkrehi 2922 12 the the DT cord-335975-m6lkrehi 2922 13 different different JJ cord-335975-m6lkrehi 2922 14 antibiotics-21 antibiotics-21 NNP cord-335975-m6lkrehi 2922 15 % % NN cord-335975-m6lkrehi 2922 16 of of IN cord-335975-m6lkrehi 2922 17 strains strain NNS cord-335975-m6lkrehi 2922 18 were be VBD cord-335975-m6lkrehi 2922 19 resistant resistant JJ cord-335975-m6lkrehi 2922 20 to to IN cord-335975-m6lkrehi 2922 21 ceftazidim ceftazidim NN cord-335975-m6lkrehi 2922 22 , , , cord-335975-m6lkrehi 2922 23 69 69 CD cord-335975-m6lkrehi 2922 24 % % NN cord-335975-m6lkrehi 2922 25 to to IN cord-335975-m6lkrehi 2922 26 ticarcillin ticarcillin NNP cord-335975-m6lkrehi 2922 27 , , , cord-335975-m6lkrehi 2922 28 66 66 CD cord-335975-m6lkrehi 2922 29 % % NN cord-335975-m6lkrehi 2922 30 to to IN cord-335975-m6lkrehi 2922 31 ciprofloxacin ciprofloxacin NN cord-335975-m6lkrehi 2922 32 , , , cord-335975-m6lkrehi 2922 33 62 62 CD cord-335975-m6lkrehi 2922 34 % % NN cord-335975-m6lkrehi 2922 35 to to IN cord-335975-m6lkrehi 2922 36 amikacin amikacin NN cord-335975-m6lkrehi 2922 37 and and CC cord-335975-m6lkrehi 2922 38 56 56 CD cord-335975-m6lkrehi 2922 39 % % NN cord-335975-m6lkrehi 2922 40 to to IN cord-335975-m6lkrehi 2922 41 imipenem imipenem NNP cord-335975-m6lkrehi 2922 42 . . . cord-335975-m6lkrehi 2923 1 Among among IN cord-335975-m6lkrehi 2923 2 the the DT cord-335975-m6lkrehi 2923 3 272 272 CD cord-335975-m6lkrehi 2923 4 imipenem imipenem NN cord-335975-m6lkrehi 2923 5 resistant resistant JJ cord-335975-m6lkrehi 2923 6 strains strain NNS cord-335975-m6lkrehi 2923 7 , , , cord-335975-m6lkrehi 2923 8 34 34 CD cord-335975-m6lkrehi 2923 9 % % NN cord-335975-m6lkrehi 2923 10 were be VBD cord-335975-m6lkrehi 2923 11 metallo metallo NN cord-335975-m6lkrehi 2923 12 - - HYPH cord-335975-m6lkrehi 2923 13 beta beta NN cord-335975-m6lkrehi 2923 14 - - HYPH cord-335975-m6lkrehi 2923 15 lactamase lactamase NN cord-335975-m6lkrehi 2923 16 producers producer NNS cord-335975-m6lkrehi 2923 17 . . . cord-335975-m6lkrehi 2924 1 The the DT cord-335975-m6lkrehi 2924 2 antibiotic antibiotic NN cord-335975-m6lkrehi 2924 3 to to IN cord-335975-m6lkrehi 2924 4 which which WDT cord-335975-m6lkrehi 2924 5 P. P. NNP cord-335975-m6lkrehi 2924 6 aeruginosa aeruginosa NN cord-335975-m6lkrehi 2924 7 was be VBD cord-335975-m6lkrehi 2924 8 the the DT cord-335975-m6lkrehi 2924 9 most most RBS cord-335975-m6lkrehi 2924 10 susceptible susceptible JJ cord-335975-m6lkrehi 2924 11 was be VBD cord-335975-m6lkrehi 2924 12 colistin colistin NNP cord-335975-m6lkrehi 2924 13 ( ( -LRB- cord-335975-m6lkrehi 2924 14 100 100 CD cord-335975-m6lkrehi 2924 15 % % NN cord-335975-m6lkrehi 2924 16 ) ) -RRB- cord-335975-m6lkrehi 2924 17 . . . cord-335975-m6lkrehi 2925 1 Multidrugresistance Multidrugresistance NNP cord-335975-m6lkrehi 2925 2 was be VBD cord-335975-m6lkrehi 2925 3 associated associate VBN cord-335975-m6lkrehi 2925 4 with with IN cord-335975-m6lkrehi 2925 5 O12 O12 NNP cord-335975-m6lkrehi 2925 6 serotype serotype NN cord-335975-m6lkrehi 2925 7 in in IN cord-335975-m6lkrehi 2925 8 67 67 CD cord-335975-m6lkrehi 2925 9 % % NN cord-335975-m6lkrehi 2925 10 of of IN cord-335975-m6lkrehi 2925 11 the the DT cord-335975-m6lkrehi 2925 12 cases case NNS cord-335975-m6lkrehi 2925 13 . . . cord-335975-m6lkrehi 2926 1 The the DT cord-335975-m6lkrehi 2926 2 global global JJ cord-335975-m6lkrehi 2926 3 frequency frequency NN cord-335975-m6lkrehi 2926 4 of of IN cord-335975-m6lkrehi 2926 5 serotypes serotypes DT cord-335975-m6lkrehi 2926 6 O12 O12 NNP cord-335975-m6lkrehi 2926 7 , , , cord-335975-m6lkrehi 2926 8 O1 o1 NN cord-335975-m6lkrehi 2926 9 and and CC cord-335975-m6lkrehi 2926 10 O2 O2 NNP cord-335975-m6lkrehi 2926 11 was be VBD cord-335975-m6lkrehi 2926 12 more more JJR cord-335975-m6lkrehi 2926 13 than than IN cord-335975-m6lkrehi 2926 14 88 88 CD cord-335975-m6lkrehi 2926 15 % % NN cord-335975-m6lkrehi 2926 16 . . . cord-335975-m6lkrehi 2927 1 Multidrug multidrug JJ cord-335975-m6lkrehi 2927 2 resistance resistance NN cord-335975-m6lkrehi 2927 3 and and CC cord-335975-m6lkrehi 2927 4 carbapenemase carbapenemase NN cord-335975-m6lkrehi 2927 5 being be VBG cord-335975-m6lkrehi 2927 6 associated associate VBN cord-335975-m6lkrehi 2927 7 with with IN cord-335975-m6lkrehi 2927 8 serotype serotype NN cord-335975-m6lkrehi 2927 9 O12 O12 NNP cord-335975-m6lkrehi 2927 10 . . . cord-335975-m6lkrehi 2928 1 Serotyping serotype VBG cord-335975-m6lkrehi 2928 2 of of IN cord-335975-m6lkrehi 2928 3 the the DT cord-335975-m6lkrehi 2928 4 strains strain NNS cord-335975-m6lkrehi 2928 5 isolated isolate VBN cord-335975-m6lkrehi 2928 6 from from IN cord-335975-m6lkrehi 2928 7 burned burn VBN cord-335975-m6lkrehi 2928 8 patients patient NNS cord-335975-m6lkrehi 2928 9 will will MD cord-335975-m6lkrehi 2928 10 help help VB cord-335975-m6lkrehi 2928 11 to to TO cord-335975-m6lkrehi 2928 12 guide guide VB cord-335975-m6lkrehi 2928 13 the the DT cord-335975-m6lkrehi 2928 14 first first JJ cord-335975-m6lkrehi 2928 15 antibiotherapy antibiotherapy NN cord-335975-m6lkrehi 2928 16 . . . cord-335975-m6lkrehi 2929 1 The the DT cord-335975-m6lkrehi 2929 2 dissemination dissemination NN cord-335975-m6lkrehi 2929 3 of of IN cord-335975-m6lkrehi 2929 4 carbapenemases carbapenemase NNS cord-335975-m6lkrehi 2929 5 strains strain NNS cord-335975-m6lkrehi 2929 6 must must MD cord-335975-m6lkrehi 2929 7 be be VB cord-335975-m6lkrehi 2929 8 contained contain VBN cord-335975-m6lkrehi 2929 9 by by IN cord-335975-m6lkrehi 2929 10 implementation implementation NN cord-335975-m6lkrehi 2929 11 of of IN cord-335975-m6lkrehi 2929 12 timely timely JJ cord-335975-m6lkrehi 2929 13 identification identification NN cord-335975-m6lkrehi 2929 14 , , , cord-335975-m6lkrehi 2929 15 strict strict JJ cord-335975-m6lkrehi 2929 16 isolation isolation NN cord-335975-m6lkrehi 2929 17 methods method NNS cord-335975-m6lkrehi 2929 18 and and CC cord-335975-m6lkrehi 2929 19 better well JJR cord-335975-m6lkrehi 2929 20 hygienic hygienic JJ cord-335975-m6lkrehi 2929 21 procedures procedure NNS cord-335975-m6lkrehi 2929 22 . . . cord-335975-m6lkrehi 2930 1 And and CC cord-335975-m6lkrehi 2930 2 respiratory respiratory JJ cord-335975-m6lkrehi 2930 3 disorders disorder NNS cord-335975-m6lkrehi 2930 4 ( ( -LRB- cord-335975-m6lkrehi 2930 5 43.5 43.5 CD cord-335975-m6lkrehi 2930 6 % % NN cord-335975-m6lkrehi 2930 7 ) ) -RRB- cord-335975-m6lkrehi 2930 8 … … NFP cord-335975-m6lkrehi 2930 9 ) ) -RRB- cord-335975-m6lkrehi 2930 10 . . . cord-335975-m6lkrehi 2931 1 The the DT cord-335975-m6lkrehi 2931 2 therapeutic therapeutic JJ cord-335975-m6lkrehi 2931 3 management management NN cord-335975-m6lkrehi 2931 4 was be VBD cord-335975-m6lkrehi 2931 5 based base VBN cord-335975-m6lkrehi 2931 6 on on IN cord-335975-m6lkrehi 2931 7 per per IN cord-335975-m6lkrehi 2931 8 operative operative JJ cord-335975-m6lkrehi 2931 9 resuscitation resuscitation NN cord-335975-m6lkrehi 2931 10 , , , cord-335975-m6lkrehi 2931 11 organ organ NN cord-335975-m6lkrehi 2931 12 failure failure NN cord-335975-m6lkrehi 2931 13 treatment treatment NN cord-335975-m6lkrehi 2931 14 , , , cord-335975-m6lkrehi 2931 15 probabilistic probabilistic JJ cord-335975-m6lkrehi 2931 16 antibiotic antibiotic JJ cord-335975-m6lkrehi 2931 17 therapy therapy NN cord-335975-m6lkrehi 2931 18 and and CC cord-335975-m6lkrehi 2931 19 median median JJ cord-335975-m6lkrehi 2931 20 laparotomy laparotomy NN cord-335975-m6lkrehi 2931 21 surgery surgery NN cord-335975-m6lkrehi 2931 22 . . . cord-335975-m6lkrehi 2932 1 The the DT cord-335975-m6lkrehi 2932 2 main main JJ cord-335975-m6lkrehi 2932 3 etiologies etiology NNS cord-335975-m6lkrehi 2932 4 of of IN cord-335975-m6lkrehi 2932 5 abdominal abdominal JJ cord-335975-m6lkrehi 2932 6 sepsis sepsis NN cord-335975-m6lkrehi 2932 7 were be VBD cord-335975-m6lkrehi 2932 8 - - HYPH cord-335975-m6lkrehi 2932 9 digestive digestive JJ cord-335975-m6lkrehi 2932 10 perforations perforation NNS cord-335975-m6lkrehi 2932 11 ( ( -LRB- cord-335975-m6lkrehi 2932 12 43.5 43.5 CD cord-335975-m6lkrehi 2932 13 % % NN cord-335975-m6lkrehi 2932 14 ) ) -RRB- cord-335975-m6lkrehi 2932 15 , , , cord-335975-m6lkrehi 2932 16 purulent purulent JJ cord-335975-m6lkrehi 2932 17 effusion effusion NN cord-335975-m6lkrehi 2932 18 ( ( -LRB- cord-335975-m6lkrehi 2932 19 38 38 CD cord-335975-m6lkrehi 2932 20 % % NN cord-335975-m6lkrehi 2932 21 ) ) -RRB- cord-335975-m6lkrehi 2932 22 , , , cord-335975-m6lkrehi 2932 23 intestinal intestinal JJ cord-335975-m6lkrehi 2932 24 necrosis necrosis NN cord-335975-m6lkrehi 2932 25 ( ( -LRB- cord-335975-m6lkrehi 2932 26 14 14 CD cord-335975-m6lkrehi 2932 27 % % NN cord-335975-m6lkrehi 2932 28 ) ) -RRB- cord-335975-m6lkrehi 2932 29 , , , cord-335975-m6lkrehi 2932 30 cholecystitis cholecystitis NN cord-335975-m6lkrehi 2932 31 ( ( -LRB- cord-335975-m6lkrehi 2932 32 12.5 12.5 CD cord-335975-m6lkrehi 2932 33 % % NN cord-335975-m6lkrehi 2932 34 ) ) -RRB- cord-335975-m6lkrehi 2932 35 . . . cord-335975-m6lkrehi 2933 1 The the DT cord-335975-m6lkrehi 2933 2 bacteriological bacteriological JJ cord-335975-m6lkrehi 2933 3 profile profile NN cord-335975-m6lkrehi 2933 4 was be VBD cord-335975-m6lkrehi 2933 5 -predominance -predominance : cord-335975-m6lkrehi 2933 6 of of IN cord-335975-m6lkrehi 2933 7 BGN BGN NNP cord-335975-m6lkrehi 2933 8 ( ( -LRB- cord-335975-m6lkrehi 2933 9 82.7 82.7 CD cord-335975-m6lkrehi 2933 10 % % NN cord-335975-m6lkrehi 2933 11 ) ) -RRB- cord-335975-m6lkrehi 2933 12 dominated dominate VBN cord-335975-m6lkrehi 2933 13 by by IN cord-335975-m6lkrehi 2933 14 E. E. NNP cord-335975-m6lkrehi 2933 15 Coli Coli NNP cord-335975-m6lkrehi 2933 16 ( ( -LRB- cord-335975-m6lkrehi 2933 17 28 28 CD cord-335975-m6lkrehi 2933 18 % % NN cord-335975-m6lkrehi 2933 19 ) ) -RRB- cord-335975-m6lkrehi 2933 20 followed follow VBN cord-335975-m6lkrehi 2933 21 by by IN cord-335975-m6lkrehi 2933 22 Klebsiella Klebsiella NNP cord-335975-m6lkrehi 2933 23 pneumoniae pneumoniae NN cord-335975-m6lkrehi 2933 24 and and CC cord-335975-m6lkrehi 2933 25 Acinetobacter Acinetobacter NNP cord-335975-m6lkrehi 2933 26 baumanii baumanii NNP cord-335975-m6lkrehi 2933 27 ( ( -LRB- cord-335975-m6lkrehi 2933 28 13.46 13.46 CD cord-335975-m6lkrehi 2933 29 % % NN cord-335975-m6lkrehi 2933 30 ) ) -RRB- cord-335975-m6lkrehi 2933 31 , , , cord-335975-m6lkrehi 2933 32 the the DT cord-335975-m6lkrehi 2933 33 mean mean JJ cord-335975-m6lkrehi 2933 34 duration duration NN cord-335975-m6lkrehi 2933 35 of of IN cord-335975-m6lkrehi 2933 36 the the DT cord-335975-m6lkrehi 2933 37 hospitalization hospitalization NN cord-335975-m6lkrehi 2933 38 was be VBD cord-335975-m6lkrehi 2933 39 7.03 7.03 CD cord-335975-m6lkrehi 2933 40 ± ± CD cord-335975-m6lkrehi 2933 41 6.65 6.65 CD cord-335975-m6lkrehi 2933 42 days day NNS cord-335975-m6lkrehi 2933 43 . . . cord-335975-m6lkrehi 2934 1 The the DT cord-335975-m6lkrehi 2934 2 mortality mortality NN cord-335975-m6lkrehi 2934 3 rate rate NN cord-335975-m6lkrehi 2934 4 was be VBD cord-335975-m6lkrehi 2934 5 57 57 CD cord-335975-m6lkrehi 2934 6 % % NN cord-335975-m6lkrehi 2934 7 . . . cord-335975-m6lkrehi 2935 1 The the DT cord-335975-m6lkrehi 2935 2 main main JJ cord-335975-m6lkrehi 2935 3 prognostic prognostic JJ cord-335975-m6lkrehi 2935 4 factors factor NNS cord-335975-m6lkrehi 2935 5 in in IN cord-335975-m6lkrehi 2935 6 our -PRON- PRP$ cord-335975-m6lkrehi 2935 7 study study NN cord-335975-m6lkrehi 2935 8 in in IN cord-335975-m6lkrehi 2935 9 univariate univariate JJ cord-335975-m6lkrehi 2935 10 analysis analysis NN cord-335975-m6lkrehi 2935 11 were be VBD cord-335975-m6lkrehi 2935 12 - - : cord-335975-m6lkrehi 2935 13 the the DT cord-335975-m6lkrehi 2935 14 advanced advanced JJ cord-335975-m6lkrehi 2935 15 age age NN cord-335975-m6lkrehi 2935 16 , , , cord-335975-m6lkrehi 2935 17 the the DT cord-335975-m6lkrehi 2935 18 diabetes diabetes NN cord-335975-m6lkrehi 2935 19 , , , cord-335975-m6lkrehi 2935 20 the the DT cord-335975-m6lkrehi 2935 21 organ organ NN cord-335975-m6lkrehi 2935 22 failure failure NN cord-335975-m6lkrehi 2935 23 , , , cord-335975-m6lkrehi 2935 24 the the DT cord-335975-m6lkrehi 2935 25 increased increase VBN cord-335975-m6lkrehi 2935 26 gravity gravity NN cord-335975-m6lkrehi 2935 27 scores score NNS cord-335975-m6lkrehi 2935 28 , , , cord-335975-m6lkrehi 2935 29 the the DT cord-335975-m6lkrehi 2935 30 time time NN cord-335975-m6lkrehi 2935 31 to to IN cord-335975-m6lkrehi 2935 32 management management NN cord-335975-m6lkrehi 2935 33 , , , cord-335975-m6lkrehi 2935 34 the the DT cord-335975-m6lkrehi 2935 35 use use NN cord-335975-m6lkrehi 2935 36 of of IN cord-335975-m6lkrehi 2935 37 catecholamines catecholamine NNS cord-335975-m6lkrehi 2935 38 and and CC cord-335975-m6lkrehi 2935 39 the the DT cord-335975-m6lkrehi 2935 40 development development NN cord-335975-m6lkrehi 2935 41 of of IN cord-335975-m6lkrehi 2935 42 septic septic JJ cord-335975-m6lkrehi 2935 43 shock shock NN cord-335975-m6lkrehi 2935 44 . . . cord-335975-m6lkrehi 2936 1 The the DT cord-335975-m6lkrehi 2936 2 multivariate multivariate JJ cord-335975-m6lkrehi 2936 3 analysis analysis NN cord-335975-m6lkrehi 2936 4 showed show VBD cord-335975-m6lkrehi 2936 5 a a DT cord-335975-m6lkrehi 2936 6 statistically statistically RB cord-335975-m6lkrehi 2936 7 significant significant JJ cord-335975-m6lkrehi 2936 8 association association NN cord-335975-m6lkrehi 2936 9 between between IN cord-335975-m6lkrehi 2936 10 the the DT cord-335975-m6lkrehi 2936 11 development development NN cord-335975-m6lkrehi 2936 12 of of IN cord-335975-m6lkrehi 2936 13 septic septic JJ cord-335975-m6lkrehi 2936 14 shock shock NN cord-335975-m6lkrehi 2936 15 , , , cord-335975-m6lkrehi 2936 16 the the DT cord-335975-m6lkrehi 2936 17 stercoral stercoral JJ cord-335975-m6lkrehi 2936 18 effusion effusion NN cord-335975-m6lkrehi 2936 19 , , , cord-335975-m6lkrehi 2936 20 the the DT cord-335975-m6lkrehi 2936 21 peptic peptic JJ cord-335975-m6lkrehi 2936 22 ulcer ulcer NN cord-335975-m6lkrehi 2936 23 perforation perforation NN cord-335975-m6lkrehi 2936 24 , , , cord-335975-m6lkrehi 2936 25 the the DT cord-335975-m6lkrehi 2936 26 operator operator NN cord-335975-m6lkrehi 2936 27 and and CC cord-335975-m6lkrehi 2936 28 the the DT cord-335975-m6lkrehi 2936 29 therapeutic therapeutic JJ cord-335975-m6lkrehi 2936 30 descalation descalation NN cord-335975-m6lkrehi 2936 31 . . . cord-335975-m6lkrehi 2937 1 The the DT cord-335975-m6lkrehi 2937 2 abdominal abdominal JJ cord-335975-m6lkrehi 2937 3 sepsis sepsis NN cord-335975-m6lkrehi 2937 4 is be VBZ cord-335975-m6lkrehi 2937 5 a a DT cord-335975-m6lkrehi 2937 6 serious serious JJ cord-335975-m6lkrehi 2937 7 affection affection NN cord-335975-m6lkrehi 2937 8 , , , cord-335975-m6lkrehi 2937 9 with with IN cord-335975-m6lkrehi 2937 10 great great JJ cord-335975-m6lkrehi 2937 11 mortality mortality NN cord-335975-m6lkrehi 2937 12 . . . cord-335975-m6lkrehi 2938 1 The the DT cord-335975-m6lkrehi 2938 2 improvement improvement NN cord-335975-m6lkrehi 2938 3 of of IN cord-335975-m6lkrehi 2938 4 its -PRON- PRP$ cord-335975-m6lkrehi 2938 5 prognosis prognosis NN cord-335975-m6lkrehi 2938 6 is be VBZ cord-335975-m6lkrehi 2938 7 based base VBN cord-335975-m6lkrehi 2938 8 on on IN cord-335975-m6lkrehi 2938 9 a a DT cord-335975-m6lkrehi 2938 10 revision revision NN cord-335975-m6lkrehi 2938 11 of of IN cord-335975-m6lkrehi 2938 12 the the DT cord-335975-m6lkrehi 2938 13 medical medical JJ cord-335975-m6lkrehi 2938 14 and and CC cord-335975-m6lkrehi 2938 15 surgical surgical JJ cord-335975-m6lkrehi 2938 16 protocols protocol NNS cord-335975-m6lkrehi 2938 17 , , , cord-335975-m6lkrehi 2938 18 and and CC cord-335975-m6lkrehi 2938 19 an an DT cord-335975-m6lkrehi 2938 20 adapted adapt VBN cord-335975-m6lkrehi 2938 21 antibiotic antibiotic JJ cord-335975-m6lkrehi 2938 22 therapy therapy NN cord-335975-m6lkrehi 2938 23 depending depend VBG cord-335975-m6lkrehi 2938 24 on on IN cord-335975-m6lkrehi 2938 25 the the DT cord-335975-m6lkrehi 2938 26 direct direct JJ cord-335975-m6lkrehi 2938 27 examination examination NN cord-335975-m6lkrehi 2938 28 of of IN cord-335975-m6lkrehi 2938 29 the the DT cord-335975-m6lkrehi 2938 30 samples sample NNS cord-335975-m6lkrehi 2938 31 , , , cord-335975-m6lkrehi 2938 32 also also RB cord-335975-m6lkrehi 2938 33 of of IN cord-335975-m6lkrehi 2938 34 the the DT cord-335975-m6lkrehi 2938 35 bacterial bacterial JJ cord-335975-m6lkrehi 2938 36 ecology ecology NN cord-335975-m6lkrehi 2938 37 of of IN cord-335975-m6lkrehi 2938 38 the the DT cord-335975-m6lkrehi 2938 39 service service NN cord-335975-m6lkrehi 2938 40 . . . cord-335975-m6lkrehi 2939 1 Introduction introduction NN cord-335975-m6lkrehi 2939 2 : : : cord-335975-m6lkrehi 2939 3 Severe severe JJ cord-335975-m6lkrehi 2939 4 acute acute JJ cord-335975-m6lkrehi 2939 5 respiratory respiratory JJ cord-335975-m6lkrehi 2939 6 infections infection NNS cord-335975-m6lkrehi 2939 7 ( ( -LRB- cord-335975-m6lkrehi 2939 8 SARI SARI NNP cord-335975-m6lkrehi 2939 9 ) ) -RRB- cord-335975-m6lkrehi 2939 10 are be VBP cord-335975-m6lkrehi 2939 11 common common JJ cord-335975-m6lkrehi 2939 12 in in IN cord-335975-m6lkrehi 2939 13 critically critically RB cord-335975-m6lkrehi 2939 14 ill ill JJ cord-335975-m6lkrehi 2939 15 patients patient NNS cord-335975-m6lkrehi 2939 16 . . . cord-335975-m6lkrehi 2940 1 Viruses virus NNS cord-335975-m6lkrehi 2940 2 can can MD cord-335975-m6lkrehi 2940 3 be be VB cord-335975-m6lkrehi 2940 4 found find VBN cord-335975-m6lkrehi 2940 5 in in IN cord-335975-m6lkrehi 2940 6 immuno immuno JJ cord-335975-m6lkrehi 2940 7 - - JJ cord-335975-m6lkrehi 2940 8 competent competent JJ cord-335975-m6lkrehi 2940 9 patients patient NNS cord-335975-m6lkrehi 2940 10 . . . cord-335975-m6lkrehi 2941 1 However however RB cord-335975-m6lkrehi 2941 2 , , , cord-335975-m6lkrehi 2941 3 the the DT cord-335975-m6lkrehi 2941 4 main main JJ cord-335975-m6lkrehi 2941 5 problem problem NN cord-335975-m6lkrehi 2941 6 for for IN cord-335975-m6lkrehi 2941 7 viral viral JJ cord-335975-m6lkrehi 2941 8 infections infection NNS cord-335975-m6lkrehi 2941 9 is be VBZ cord-335975-m6lkrehi 2941 10 the the DT cord-335975-m6lkrehi 2941 11 diagnosis diagnosis NN cord-335975-m6lkrehi 2941 12 , , , cord-335975-m6lkrehi 2941 13 isolation isolation NN cord-335975-m6lkrehi 2941 14 of of IN cord-335975-m6lkrehi 2941 15 the the DT cord-335975-m6lkrehi 2941 16 pathogen pathogen NN cord-335975-m6lkrehi 2941 17 is be VBZ cord-335975-m6lkrehi 2941 18 often often RB cord-335975-m6lkrehi 2941 19 difficult difficult JJ cord-335975-m6lkrehi 2941 20 and and CC cord-335975-m6lkrehi 2941 21 the the DT cord-335975-m6lkrehi 2941 22 symptoms symptom NNS cord-335975-m6lkrehi 2941 23 not not RB cord-335975-m6lkrehi 2941 24 specific specific JJ cord-335975-m6lkrehi 2941 25 . . . cord-335975-m6lkrehi 2942 1 The the DT cord-335975-m6lkrehi 2942 2 aims aim NNS cord-335975-m6lkrehi 2942 3 of of IN cord-335975-m6lkrehi 2942 4 this this DT cord-335975-m6lkrehi 2942 5 study study NN cord-335975-m6lkrehi 2942 6 were be VBD cord-335975-m6lkrehi 2942 7 to to IN cord-335975-m6lkrehi 2942 8 describing describe VBG cord-335975-m6lkrehi 2942 9 the the DT cord-335975-m6lkrehi 2942 10 epidemiological epidemiological JJ cord-335975-m6lkrehi 2942 11 characteristics characteristic NNS cord-335975-m6lkrehi 2942 12 of of IN cord-335975-m6lkrehi 2942 13 viral viral JJ cord-335975-m6lkrehi 2942 14 respiratory respiratory JJ cord-335975-m6lkrehi 2942 15 infections infection NNS cord-335975-m6lkrehi 2942 16 , , , cord-335975-m6lkrehi 2942 17 to to TO cord-335975-m6lkrehi 2942 18 identify identify VB cord-335975-m6lkrehi 2942 19 factors factor NNS cord-335975-m6lkrehi 2942 20 predictive predictive JJ cord-335975-m6lkrehi 2942 21 of of IN cord-335975-m6lkrehi 2942 22 a a DT cord-335975-m6lkrehi 2942 23 poor poor JJ cord-335975-m6lkrehi 2942 24 outcome outcome NN cord-335975-m6lkrehi 2942 25 . . . cord-335975-m6lkrehi 2943 1 Introduction introduction NN cord-335975-m6lkrehi 2943 2 : : : cord-335975-m6lkrehi 2944 1 In in IN cord-335975-m6lkrehi 2944 2 septic septic JJ cord-335975-m6lkrehi 2944 3 shock shock NN cord-335975-m6lkrehi 2944 4 there there EX cord-335975-m6lkrehi 2944 5 are be VBP cord-335975-m6lkrehi 2944 6 physiological physiological JJ cord-335975-m6lkrehi 2944 7 changes change NNS cord-335975-m6lkrehi 2944 8 with with IN cord-335975-m6lkrehi 2944 9 an an DT cord-335975-m6lkrehi 2944 10 increase increase NN cord-335975-m6lkrehi 2944 11 in in IN cord-335975-m6lkrehi 2944 12 the the DT cord-335975-m6lkrehi 2944 13 volume volume NN cord-335975-m6lkrehi 2944 14 of of IN cord-335975-m6lkrehi 2944 15 distribution distribution NN cord-335975-m6lkrehi 2944 16 , , , cord-335975-m6lkrehi 2944 17 with with IN cord-335975-m6lkrehi 2944 18 implications implication NNS cord-335975-m6lkrehi 2944 19 for for IN cord-335975-m6lkrehi 2944 20 pharmacokinetics pharmacokinetic NNS cord-335975-m6lkrehi 2944 21 of of IN cord-335975-m6lkrehi 2944 22 antibiotics antibiotic NNS cord-335975-m6lkrehi 2944 23 that that WDT cord-335975-m6lkrehi 2944 24 make make VBP cord-335975-m6lkrehi 2944 25 recommended recommend VBN cord-335975-m6lkrehi 2944 26 doses dose NNS cord-335975-m6lkrehi 2944 27 potentially potentially RB cord-335975-m6lkrehi 2944 28 inadequate inadequate JJ cord-335975-m6lkrehi 2944 29 for for IN cord-335975-m6lkrehi 2944 30 target target NN cord-335975-m6lkrehi 2944 31 organisms organism NNS cord-335975-m6lkrehi 2944 32 with with IN cord-335975-m6lkrehi 2944 33 highest high JJS cord-335975-m6lkrehi 2944 34 minimal minimal JJ cord-335975-m6lkrehi 2944 35 inhibitory inhibitory JJ cord-335975-m6lkrehi 2944 36 concentrations concentration NNS cord-335975-m6lkrehi 2944 37 . . . cord-335975-m6lkrehi 2945 1 To to TO cord-335975-m6lkrehi 2945 2 cover cover VB cord-335975-m6lkrehi 2945 3 these these DT cord-335975-m6lkrehi 2945 4 bacteria bacteria NNS cord-335975-m6lkrehi 2945 5 , , , cord-335975-m6lkrehi 2945 6 peak peak NN cord-335975-m6lkrehi 2945 7 serum serum NN cord-335975-m6lkrehi 2945 8 concentration concentration NN cord-335975-m6lkrehi 2945 9 ( ( -LRB- cord-335975-m6lkrehi 2945 10 Cmax Cmax NNP cord-335975-m6lkrehi 2945 11 ) ) -RRB- cord-335975-m6lkrehi 2945 12 target target NN cord-335975-m6lkrehi 2945 13 is be VBZ cord-335975-m6lkrehi 2945 14 64 64 CD cord-335975-m6lkrehi 2945 15 - - SYM cord-335975-m6lkrehi 2945 16 80 80 CD cord-335975-m6lkrehi 2945 17 pg pg NN cord-335975-m6lkrehi 2945 18 ml ml NN cord-335975-m6lkrehi 2945 19 . . . cord-335975-m6lkrehi 2946 1 Identification identification NN cord-335975-m6lkrehi 2946 2 of of IN cord-335975-m6lkrehi 2946 3 predictive predictive JJ cord-335975-m6lkrehi 2946 4 factors factor NNS cord-335975-m6lkrehi 2946 5 for for IN cord-335975-m6lkrehi 2946 6 insufficient insufficient JJ cord-335975-m6lkrehi 2946 7 Cmax Cmax NNP cord-335975-m6lkrehi 2946 8 , , , cord-335975-m6lkrehi 2946 9 in in IN cord-335975-m6lkrehi 2946 10 common common JJ cord-335975-m6lkrehi 2946 11 practice practice NN cord-335975-m6lkrehi 2946 12 , , , cord-335975-m6lkrehi 2946 13 would would MD cord-335975-m6lkrehi 2946 14 make make VB cord-335975-m6lkrehi 2946 15 it -PRON- PRP cord-335975-m6lkrehi 2946 16 possible possible JJ cord-335975-m6lkrehi 2946 17 to to TO cord-335975-m6lkrehi 2946 18 target target VB cord-335975-m6lkrehi 2946 19 the the DT cord-335975-m6lkrehi 2946 20 patients patient NNS cord-335975-m6lkrehi 2946 21 at at IN cord-335975-m6lkrehi 2946 22 risk risk NN cord-335975-m6lkrehi 2946 23 in in IN cord-335975-m6lkrehi 2946 24 order order NN cord-335975-m6lkrehi 2946 25 to to TO cord-335975-m6lkrehi 2946 26 optimize optimize VB cord-335975-m6lkrehi 2946 27 dosage dosage NN cord-335975-m6lkrehi 2946 28 of of IN cord-335975-m6lkrehi 2946 29 antibiotic antibiotic NN cord-335975-m6lkrehi 2946 30 to to TO cord-335975-m6lkrehi 2946 31 be be VB cord-335975-m6lkrehi 2946 32 administered administer VBN cord-335975-m6lkrehi 2946 33 . . . cord-335975-m6lkrehi 2947 1 Objective objective NN cord-335975-m6lkrehi 2947 2 of of IN cord-335975-m6lkrehi 2947 3 this this DT cord-335975-m6lkrehi 2947 4 study study NN cord-335975-m6lkrehi 2947 5 was be VBD cord-335975-m6lkrehi 2947 6 to to TO cord-335975-m6lkrehi 2947 7 determine determine VB cord-335975-m6lkrehi 2947 8 predictive predictive JJ cord-335975-m6lkrehi 2947 9 factors factor NNS cord-335975-m6lkrehi 2947 10 of of IN cord-335975-m6lkrehi 2947 11 Amikacin Amikacin NNP cord-335975-m6lkrehi 2947 12 's 's POS cord-335975-m6lkrehi 2947 13 Cmax Cmax NNP cord-335975-m6lkrehi 2947 14 insufficient insufficient JJ cord-335975-m6lkrehi 2947 15 independently independently RB cord-335975-m6lkrehi 2947 16 of of IN cord-335975-m6lkrehi 2947 17 the the DT cord-335975-m6lkrehi 2947 18 dosage dosage NN cord-335975-m6lkrehi 2947 19 . . . cord-335975-m6lkrehi 2948 1 Patients patient NNS cord-335975-m6lkrehi 2948 2 and and CC cord-335975-m6lkrehi 2948 3 methods method NNS cord-335975-m6lkrehi 2949 1 : : : cord-335975-m6lkrehi 2949 2 This this DT cord-335975-m6lkrehi 2949 3 was be VBD cord-335975-m6lkrehi 2949 4 a a DT cord-335975-m6lkrehi 2949 5 retrospective retrospective JJ cord-335975-m6lkrehi 2949 6 study study NN cord-335975-m6lkrehi 2949 7 carried carry VBD cord-335975-m6lkrehi 2949 8 out out RP cord-335975-m6lkrehi 2949 9 between between IN cord-335975-m6lkrehi 2949 10 August August NNP cord-335975-m6lkrehi 2949 11 2013 2013 CD cord-335975-m6lkrehi 2949 12 and and CC cord-335975-m6lkrehi 2949 13 November November NNP cord-335975-m6lkrehi 2949 14 2015 2015 CD cord-335975-m6lkrehi 2949 15 in in IN cord-335975-m6lkrehi 2949 16 ICU ICU NNP cord-335975-m6lkrehi 2949 17 of of IN cord-335975-m6lkrehi 2949 18 our -PRON- PRP$ cord-335975-m6lkrehi 2949 19 Hospital Hospital NNP cord-335975-m6lkrehi 2949 20 . . . cord-335975-m6lkrehi 2950 1 All all DT cord-335975-m6lkrehi 2950 2 adult adult NN cord-335975-m6lkrehi 2950 3 patient patient NN cord-335975-m6lkrehi 2950 4 receiving receive VBG cord-335975-m6lkrehi 2950 5 an an DT cord-335975-m6lkrehi 2950 6 initial initial JJ cord-335975-m6lkrehi 2950 7 injection injection NN cord-335975-m6lkrehi 2950 8 of of IN cord-335975-m6lkrehi 2950 9 Amikacin Amikacin NNP cord-335975-m6lkrehi 2950 10 between between IN cord-335975-m6lkrehi 2950 11 20 20 CD cord-335975-m6lkrehi 2950 12 and and CC cord-335975-m6lkrehi 2950 13 30 30 CD cord-335975-m6lkrehi 2950 14 mg mg NNP cord-335975-m6lkrehi 2950 15 kg kg NNS cord-335975-m6lkrehi 2950 16 were be VBD cord-335975-m6lkrehi 2950 17 included include VBN cord-335975-m6lkrehi 2950 18 . . . cord-335975-m6lkrehi 2951 1 Clinical clinical JJ cord-335975-m6lkrehi 2951 2 data datum NNS cord-335975-m6lkrehi 2951 3 collected collect VBD cord-335975-m6lkrehi 2951 4 were be VBD cord-335975-m6lkrehi 2951 5 - - HYPH cord-335975-m6lkrehi 2951 6 Amikacin amikacin JJ cord-335975-m6lkrehi 2951 7 dosage dosage NN cord-335975-m6lkrehi 2951 8 , , , cord-335975-m6lkrehi 2951 9 Body Body NNP cord-335975-m6lkrehi 2951 10 Mass Mass NNP cord-335975-m6lkrehi 2951 11 Index Index NNP cord-335975-m6lkrehi 2951 12 ( ( -LRB- cord-335975-m6lkrehi 2951 13 BMI BMI NNP cord-335975-m6lkrehi 2951 14 ) ) -RRB- cord-335975-m6lkrehi 2951 15 , , , cord-335975-m6lkrehi 2951 16 Mechanical mechanical JJ cord-335975-m6lkrehi 2951 17 ventilation ventilation NN cord-335975-m6lkrehi 2951 18 ( ( -LRB- cord-335975-m6lkrehi 2951 19 MV MV NNP cord-335975-m6lkrehi 2951 20 ) ) -RRB- cord-335975-m6lkrehi 2951 21 , , . cord-335975-m6lkrehi 2952 1 mean mean VB cord-335975-m6lkrehi 2952 2 arterial arterial JJ cord-335975-m6lkrehi 2952 3 pressure pressure NN cord-335975-m6lkrehi 2952 4 ( ( -LRB- cord-335975-m6lkrehi 2952 5 MAP MAP NNP cord-335975-m6lkrehi 2952 6 ) ) -RRB- cord-335975-m6lkrehi 2952 7 , , , cord-335975-m6lkrehi 2952 8 use use NN cord-335975-m6lkrehi 2952 9 of of IN cord-335975-m6lkrehi 2952 10 Noradrenaline Noradrenaline NNP cord-335975-m6lkrehi 2952 11 and and CC cord-335975-m6lkrehi 2952 12 continuous continuous JJ cord-335975-m6lkrehi 2952 13 hemofiltration hemofiltration NN cord-335975-m6lkrehi 2952 14 ( ( -LRB- cord-335975-m6lkrehi 2952 15 CVVH CVVH NNP cord-335975-m6lkrehi 2952 16 ) ) -RRB- cord-335975-m6lkrehi 2952 17 . . . cord-335975-m6lkrehi 2953 1 Biological biological JJ cord-335975-m6lkrehi 2953 2 elements element NNS cord-335975-m6lkrehi 2953 3 were be VBD cord-335975-m6lkrehi 2953 4 collected collect VBN cord-335975-m6lkrehi 2953 5 and and CC cord-335975-m6lkrehi 2953 6 for for IN cord-335975-m6lkrehi 2953 7 each each DT cord-335975-m6lkrehi 2953 8 , , , cord-335975-m6lkrehi 2953 9 the the DT cord-335975-m6lkrehi 2953 10 last last JJ cord-335975-m6lkrehi 2953 11 result result NN cord-335975-m6lkrehi 2953 12 in in IN cord-335975-m6lkrehi 2953 13 the the DT cord-335975-m6lkrehi 2953 14 24 24 CD cord-335975-m6lkrehi 2953 15 h h NN cord-335975-m6lkrehi 2953 16 prior prior RB cord-335975-m6lkrehi 2953 17 to to IN cord-335975-m6lkrehi 2953 18 admission admission NN cord-335975-m6lkrehi 2953 19 and and CC cord-335975-m6lkrehi 2953 20 that that IN cord-335975-m6lkrehi 2953 21 at at IN cord-335975-m6lkrehi 2953 22 the the DT cord-335975-m6lkrehi 2953 23 patient patient NN cord-335975-m6lkrehi 2953 24 's 's POS cord-335975-m6lkrehi 2953 25 entry entry NN cord-335975-m6lkrehi 2953 26 into into IN cord-335975-m6lkrehi 2953 27 ICU ICU NNP cord-335975-m6lkrehi 2953 28 were be VBD cord-335975-m6lkrehi 2953 29 added add VBN cord-335975-m6lkrehi 2953 30 to to IN cord-335975-m6lkrehi 2953 31 analysis analysis NN cord-335975-m6lkrehi 2953 32 . . . cord-335975-m6lkrehi 2954 1 A a DT cord-335975-m6lkrehi 2954 2 comparison comparison NN cord-335975-m6lkrehi 2954 3 of of IN cord-335975-m6lkrehi 2954 4 this this DT cord-335975-m6lkrehi 2954 5 clinical clinical JJ cord-335975-m6lkrehi 2954 6 and and CC cord-335975-m6lkrehi 2954 7 biological biological JJ cord-335975-m6lkrehi 2954 8 variables variable NNS cord-335975-m6lkrehi 2954 9 was be VBD cord-335975-m6lkrehi 2954 10 made make VBN cord-335975-m6lkrehi 2954 11 between between IN cord-335975-m6lkrehi 2954 12 two two CD cord-335975-m6lkrehi 2954 13 groups group NNS cord-335975-m6lkrehi 2954 14 - - : cord-335975-m6lkrehi 2954 15 the the DT cord-335975-m6lkrehi 2954 16 first first JJ cord-335975-m6lkrehi 2954 17 one one CD cord-335975-m6lkrehi 2954 18 with with IN cord-335975-m6lkrehi 2954 19 an an DT cord-335975-m6lkrehi 2954 20 ineffective ineffective JJ cord-335975-m6lkrehi 2954 21 Cmax Cmax NNP cord-335975-m6lkrehi 2954 22 of of IN cord-335975-m6lkrehi 2954 23 Amikacin Amikacin NNP cord-335975-m6lkrehi 2954 24 ( ( -LRB- cord-335975-m6lkrehi 2954 25 < < NNP cord-335975-m6lkrehi 2954 26 64 64 CD cord-335975-m6lkrehi 2954 27 pg pg NN cord-335975-m6lkrehi 2954 28 ml ml NN cord-335975-m6lkrehi 2954 29 ) ) -RRB- cord-335975-m6lkrehi 2954 30 and and CC cord-335975-m6lkrehi 2954 31 the the DT cord-335975-m6lkrehi 2954 32 second second JJ cord-335975-m6lkrehi 2954 33 with with IN cord-335975-m6lkrehi 2954 34 an an DT cord-335975-m6lkrehi 2954 35 effective effective JJ cord-335975-m6lkrehi 2954 36 Cmax Cmax NNP cord-335975-m6lkrehi 2954 37 of of IN cord-335975-m6lkrehi 2954 38 Amikacin Amikacin NNP cord-335975-m6lkrehi 2954 39 ( ( -LRB- cord-335975-m6lkrehi 2954 40 > > NFP cord-335975-m6lkrehi 2954 41 64 64 CD cord-335975-m6lkrehi 2954 42 pg pg NN cord-335975-m6lkrehi 2954 43 ml ml NN cord-335975-m6lkrehi 2954 44 ) ) -RRB- cord-335975-m6lkrehi 2954 45 . . . cord-335975-m6lkrehi 2955 1 Results result NNS cord-335975-m6lkrehi 2955 2 : : : cord-335975-m6lkrehi 2955 3 191 191 CD cord-335975-m6lkrehi 2955 4 patients patient NNS cord-335975-m6lkrehi 2955 5 were be VBD cord-335975-m6lkrehi 2955 6 selected select VBN cord-335975-m6lkrehi 2955 7 for for IN cord-335975-m6lkrehi 2955 8 statistical statistical JJ cord-335975-m6lkrehi 2955 9 analysis analysis NN cord-335975-m6lkrehi 2955 10 . . . cord-335975-m6lkrehi 2956 1 Median median JJ cord-335975-m6lkrehi 2956 2 dosage dosage NN cord-335975-m6lkrehi 2956 3 was be VBD cord-335975-m6lkrehi 2956 4 22.5 22.5 CD cord-335975-m6lkrehi 2956 5 mg mg NNP cord-335975-m6lkrehi 2956 6 kg kg NNS cord-335975-m6lkrehi 2956 7 for for IN cord-335975-m6lkrehi 2956 8 a a DT cord-335975-m6lkrehi 2956 9 median median JJ cord-335975-m6lkrehi 2956 10 Cmax Cmax NNP cord-335975-m6lkrehi 2956 11 at at IN cord-335975-m6lkrehi 2956 12 72.1 72.1 CD cord-335975-m6lkrehi 2956 13 mg mg NNP cord-335975-m6lkrehi 2956 14 l. l. NNP cord-335975-m6lkrehi 2957 1 For for IN cord-335975-m6lkrehi 2957 2 77 77 CD cord-335975-m6lkrehi 2957 3 patients patient NNS cord-335975-m6lkrehi 2957 4 , , , cord-335975-m6lkrehi 2957 5 Cmax Cmax NNP cord-335975-m6lkrehi 2957 6 was be VBD cord-335975-m6lkrehi 2957 7 less less JJR cord-335975-m6lkrehi 2957 8 than than IN cord-335975-m6lkrehi 2957 9 64 64 CD cord-335975-m6lkrehi 2957 10 mg mg NNP cord-335975-m6lkrehi 2957 11 l l NNP cord-335975-m6lkrehi 2957 12 and and CC cord-335975-m6lkrehi 2957 13 in in IN cord-335975-m6lkrehi 2957 14 53 53 CD cord-335975-m6lkrehi 2957 15 patients patient NNS cord-335975-m6lkrehi 2957 16 , , , cord-335975-m6lkrehi 2957 17 it -PRON- PRP cord-335975-m6lkrehi 2957 18 was be VBD cord-335975-m6lkrehi 2958 1 greater great JJR cord-335975-m6lkrehi 2958 2 than than IN cord-335975-m6lkrehi 2958 3 80 80 CD cord-335975-m6lkrehi 2959 1 mg mg NNP cord-335975-m6lkrehi 2959 2 l. l. NNP cord-335975-m6lkrehi 2960 1 There there EX cord-335975-m6lkrehi 2960 2 was be VBD cord-335975-m6lkrehi 2960 3 a a DT cord-335975-m6lkrehi 2960 4 statistically statistically RB cord-335975-m6lkrehi 2960 5 significant significant JJ cord-335975-m6lkrehi 2960 6 relationship relationship NN cord-335975-m6lkrehi 2960 7 between between IN cord-335975-m6lkrehi 2960 8 a a DT cord-335975-m6lkrehi 2960 9 Cmax Cmax NNP cord-335975-m6lkrehi 2960 10 greater great JJR cord-335975-m6lkrehi 2960 11 than than IN cord-335975-m6lkrehi 2960 12 64 64 CD cord-335975-m6lkrehi 2960 13 mg mg NNP cord-335975-m6lkrehi 2960 14 l l NN cord-335975-m6lkrehi 2960 15 and and CC cord-335975-m6lkrehi 2960 16 MV MV NNP cord-335975-m6lkrehi 2960 17 , , , cord-335975-m6lkrehi 2960 18 BMI BMI NNP cord-335975-m6lkrehi 2960 19 , , , cord-335975-m6lkrehi 2960 20 PCT PCT NNP cord-335975-m6lkrehi 2960 21 measured measure VBD cord-335975-m6lkrehi 2960 22 before before RB cord-335975-m6lkrehi 2960 23 and and CC cord-335975-m6lkrehi 2960 24 after after IN cord-335975-m6lkrehi 2960 25 admission admission NN cord-335975-m6lkrehi 2960 26 , , , cord-335975-m6lkrehi 2960 27 albumin albumin NN cord-335975-m6lkrehi 2960 28 after after IN cord-335975-m6lkrehi 2960 29 admission admission NN cord-335975-m6lkrehi 2960 30 , , , cord-335975-m6lkrehi 2960 31 hemoglobinemia hemoglobinemia NN cord-335975-m6lkrehi 2960 32 , , , cord-335975-m6lkrehi 2960 33 hematocrit hematocrit NN cord-335975-m6lkrehi 2960 34 level level NN cord-335975-m6lkrehi 2960 35 after after IN cord-335975-m6lkrehi 2960 36 admission admission NN cord-335975-m6lkrehi 2960 37 , , , cord-335975-m6lkrehi 2960 38 the the DT cord-335975-m6lkrehi 2960 39 rate rate NN cord-335975-m6lkrehi 2960 40 of of IN cord-335975-m6lkrehi 2960 41 urea urea NN cord-335975-m6lkrehi 2960 42 after after IN cord-335975-m6lkrehi 2960 43 admission admission NN cord-335975-m6lkrehi 2960 44 ( ( -LRB- cord-335975-m6lkrehi 2960 45 Table table NN cord-335975-m6lkrehi 2960 46 1 1 CD cord-335975-m6lkrehi 2960 47 ) ) -RRB- cord-335975-m6lkrehi 2960 48 . . . cord-335975-m6lkrehi 2961 1 A a DT cord-335975-m6lkrehi 2961 2 low low JJ cord-335975-m6lkrehi 2961 3 BMI bmi NN cord-335975-m6lkrehi 2961 4 was be VBD cord-335975-m6lkrehi 2961 5 associated associate VBN cord-335975-m6lkrehi 2961 6 with with IN cord-335975-m6lkrehi 2961 7 Cmax Cmax NNP cord-335975-m6lkrehi 2961 8 < < XX cord-335975-m6lkrehi 2961 9 64 64 CD cord-335975-m6lkrehi 2961 10 mg mg NNP cord-335975-m6lkrehi 2961 11 l. l. NNP cord-335975-m6lkrehi 2961 12 Discussion discussion NN cord-335975-m6lkrehi 2961 13 : : : cord-335975-m6lkrehi 2962 1 These these DT cord-335975-m6lkrehi 2962 2 results result NNS cord-335975-m6lkrehi 2962 3 remain remain VBP cord-335975-m6lkrehi 2962 4 comparable comparable JJ cord-335975-m6lkrehi 2962 5 to to IN cord-335975-m6lkrehi 2962 6 those those DT cord-335975-m6lkrehi 2962 7 found find VBN cord-335975-m6lkrehi 2962 8 by by IN cord-335975-m6lkrehi 2962 9 Taccone Taccone NNP cord-335975-m6lkrehi 2962 10 in in IN cord-335975-m6lkrehi 2962 11 2010 2010 CD cord-335975-m6lkrehi 2962 12 , , , cord-335975-m6lkrehi 2962 13 with with IN cord-335975-m6lkrehi 2962 14 dosages dosage NNS cord-335975-m6lkrehi 2962 15 of of IN cord-335975-m6lkrehi 2962 16 25 25 CD cord-335975-m6lkrehi 2962 17 mg mg NNP cord-335975-m6lkrehi 2962 18 kg kg NNS cord-335975-m6lkrehi 2962 19 having have VBG cord-335975-m6lkrehi 2962 20 only only RB cord-335975-m6lkrehi 2962 21 70 70 CD cord-335975-m6lkrehi 2962 22 % % NN cord-335975-m6lkrehi 2962 23 of of IN cord-335975-m6lkrehi 2962 24 the the DT cord-335975-m6lkrehi 2962 25 peaks peak NNS cord-335975-m6lkrehi 2962 26 above above IN cord-335975-m6lkrehi 2962 27 64 64 CD cord-335975-m6lkrehi 2962 28 mg mg NN cord-335975-m6lkrehi 2962 29 l l NN cord-335975-m6lkrehi 2962 30 + + CC cord-335975-m6lkrehi 2962 31 comparable comparable JJ cord-335975-m6lkrehi 2962 32 also also RB cord-335975-m6lkrehi 2962 33 to to IN cord-335975-m6lkrehi 2962 34 Montmollin Montmollin NNP cord-335975-m6lkrehi 2962 35 's 's POS cord-335975-m6lkrehi 2962 36 study study NN cord-335975-m6lkrehi 2962 37 in in IN cord-335975-m6lkrehi 2962 38 2014 2014 CD cord-335975-m6lkrehi 2962 39 . . . cord-335975-m6lkrehi 2963 1 Conclusion conclusion NN cord-335975-m6lkrehi 2963 2 : : : cord-335975-m6lkrehi 2963 3 MV MV NNP cord-335975-m6lkrehi 2963 4 , , , cord-335975-m6lkrehi 2963 5 BMI BMI NNP cord-335975-m6lkrehi 2963 6 , , , cord-335975-m6lkrehi 2963 7 pre pre JJ cord-335975-m6lkrehi 2963 8 - - JJ cord-335975-m6lkrehi 2963 9 and and CC cord-335975-m6lkrehi 2963 10 post post JJ cord-335975-m6lkrehi 2963 11 - - JJ cord-335975-m6lkrehi 2963 12 admission admission JJ cord-335975-m6lkrehi 2963 13 PCT PCT NNP cord-335975-m6lkrehi 2963 14 , , , cord-335975-m6lkrehi 2963 15 and and CC cord-335975-m6lkrehi 2963 16 albumin albumin NN cord-335975-m6lkrehi 2963 17 , , , cord-335975-m6lkrehi 2963 18 hemoglobin hemoglobin NN cord-335975-m6lkrehi 2963 19 after after IN cord-335975-m6lkrehi 2963 20 admission admission NN cord-335975-m6lkrehi 2963 21 , , , cord-335975-m6lkrehi 2963 22 hematocrit hematocrit NN cord-335975-m6lkrehi 2963 23 and and CC cord-335975-m6lkrehi 2963 24 urea urea NN cord-335975-m6lkrehi 2963 25 after after IN cord-335975-m6lkrehi 2963 26 admission admission NN cord-335975-m6lkrehi 2963 27 seems seem VBZ cord-335975-m6lkrehi 2963 28 to to TO cord-335975-m6lkrehi 2963 29 be be VB cord-335975-m6lkrehi 2963 30 predictive predictive JJ cord-335975-m6lkrehi 2963 31 criteria criterion NNS cord-335975-m6lkrehi 2963 32 for for IN cord-335975-m6lkrehi 2963 33 insufficient insufficient JJ cord-335975-m6lkrehi 2963 34 amikacin amikacin NNS cord-335975-m6lkrehi 2963 35 's 's POS cord-335975-m6lkrehi 2963 36 Cmax Cmax NNP cord-335975-m6lkrehi 2963 37 independently independently RB cord-335975-m6lkrehi 2963 38 of of IN cord-335975-m6lkrehi 2963 39 dosage dosage NN cord-335975-m6lkrehi 2963 40 . . . cord-335975-m6lkrehi 2964 1 Our -PRON- PRP$ cord-335975-m6lkrehi 2964 2 study study NN cord-335975-m6lkrehi 2964 3 was be VBD cord-335975-m6lkrehi 2964 4 limited limit VBN cord-335975-m6lkrehi 2964 5 to to IN cord-335975-m6lkrehi 2964 6 one one CD cord-335975-m6lkrehi 2964 7 ICU ICU NNP cord-335975-m6lkrehi 2964 8 , , , cord-335975-m6lkrehi 2964 9 a a DT cord-335975-m6lkrehi 2964 10 heterogeneous heterogeneous JJ cord-335975-m6lkrehi 2964 11 recruitment recruitment NN cord-335975-m6lkrehi 2964 12 , , , cord-335975-m6lkrehi 2964 13 and and CC cord-335975-m6lkrehi 2964 14 that that IN cord-335975-m6lkrehi 2964 15 all all DT cord-335975-m6lkrehi 2964 16 samples sample NNS cord-335975-m6lkrehi 2964 17 have have VBP cord-335975-m6lkrehi 2964 18 been be VBN cord-335975-m6lkrehi 2964 19 taken take VBN cord-335975-m6lkrehi 2964 20 at at IN cord-335975-m6lkrehi 2964 21 the the DT cord-335975-m6lkrehi 2964 22 right right JJ cord-335975-m6lkrehi 2964 23 time time NN cord-335975-m6lkrehi 2964 24 . . . cord-335975-m6lkrehi 2965 1 Introduction introduction NN cord-335975-m6lkrehi 2965 2 : : : cord-335975-m6lkrehi 2966 1 This this DT cord-335975-m6lkrehi 2966 2 study study NN cord-335975-m6lkrehi 2966 3 aimed aim VBD cord-335975-m6lkrehi 2966 4 to to TO cord-335975-m6lkrehi 2966 5 assess assess VB cord-335975-m6lkrehi 2966 6 whether whether IN cord-335975-m6lkrehi 2966 7 augmented augment VBN cord-335975-m6lkrehi 2966 8 renal renal JJ cord-335975-m6lkrehi 2966 9 clearance clearance NN cord-335975-m6lkrehi 2966 10 ( ( -LRB- cord-335975-m6lkrehi 2966 11 ARC ARC NNP cord-335975-m6lkrehi 2966 12 ) ) -RRB- cord-335975-m6lkrehi 2966 13 impacts impact NNS cord-335975-m6lkrehi 2966 14 negatively negatively RB cord-335975-m6lkrehi 2966 15 on on IN cord-335975-m6lkrehi 2966 16 ceftriaxone ceftriaxone JJ cord-335975-m6lkrehi 2966 17 pharmacokinetic pharmacokinetic JJ cord-335975-m6lkrehi 2966 18 pharmacodynamics pharmacodynamic NNS cord-335975-m6lkrehi 2966 19 ( ( -LRB- cord-335975-m6lkrehi 2966 20 PK PK NNP cord-335975-m6lkrehi 2966 21 / / SYM cord-335975-m6lkrehi 2966 22 PD PD NNP cord-335975-m6lkrehi 2966 23 ) ) -RRB- cord-335975-m6lkrehi 2966 24 target target NN cord-335975-m6lkrehi 2966 25 attainment attainment JJ cord-335975-m6lkrehi 2966 26 in in IN cord-335975-m6lkrehi 2966 27 critically critically RB cord-335975-m6lkrehi 2966 28 ill ill JJ cord-335975-m6lkrehi 2966 29 patients patient NNS cord-335975-m6lkrehi 2966 30 receiving receive VBG cord-335975-m6lkrehi 2966 31 2 2 CD cord-335975-m6lkrehi 2966 32 g g NN cord-335975-m6lkrehi 2966 33 day day NN cord-335975-m6lkrehi 2966 34 by by IN cord-335975-m6lkrehi 2966 35 intermittent intermittent JJ cord-335975-m6lkrehi 2966 36 infusion infusion NN cord-335975-m6lkrehi 2966 37 . . . cord-335975-m6lkrehi 2967 1 Patients patient NNS cord-335975-m6lkrehi 2967 2 and and CC cord-335975-m6lkrehi 2967 3 methods method NNS cord-335975-m6lkrehi 2967 4 : : : cord-335975-m6lkrehi 2967 5 Over over IN cord-335975-m6lkrehi 2967 6 an an DT cord-335975-m6lkrehi 2967 7 8-month 8-month JJ cord-335975-m6lkrehi 2967 8 period period NN cord-335975-m6lkrehi 2967 9 , , , cord-335975-m6lkrehi 2967 10 all all DT cord-335975-m6lkrehi 2967 11 critically critically RB cord-335975-m6lkrehi 2967 12 ill ill JJ cord-335975-m6lkrehi 2967 13 patients patient NNS cord-335975-m6lkrehi 2967 14 treated treat VBN cord-335975-m6lkrehi 2967 15 by by IN cord-335975-m6lkrehi 2967 16 ceftriaxone ceftriaxone NN cord-335975-m6lkrehi 2967 17 for for IN cord-335975-m6lkrehi 2967 18 a a DT cord-335975-m6lkrehi 2967 19 first first JJ cord-335975-m6lkrehi 2967 20 episode episode NN cord-335975-m6lkrehi 2967 21 of of IN cord-335975-m6lkrehi 2967 22 sepsis sepsis NN cord-335975-m6lkrehi 2967 23 without without IN cord-335975-m6lkrehi 2967 24 renal renal JJ cord-335975-m6lkrehi 2967 25 impairment impairment NN cord-335975-m6lkrehi 2967 26 were be VBD cord-335975-m6lkrehi 2967 27 eligible eligible JJ cord-335975-m6lkrehi 2967 28 . . . cord-335975-m6lkrehi 2968 1 During during IN cord-335975-m6lkrehi 2968 2 the the DT cord-335975-m6lkrehi 2968 3 first first JJ cord-335975-m6lkrehi 2968 4 3 3 CD cord-335975-m6lkrehi 2968 5 days day NNS cord-335975-m6lkrehi 2968 6 of of IN cord-335975-m6lkrehi 2968 7 antimicrobial antimicrobial JJ cord-335975-m6lkrehi 2968 8 therapy therapy NN cord-335975-m6lkrehi 2968 9 , , , cord-335975-m6lkrehi 2968 10 every every DT cord-335975-m6lkrehi 2968 11 patient patient NN cord-335975-m6lkrehi 2968 12 underwent undergo VBD cord-335975-m6lkrehi 2968 13 24-hour 24-hour JJ cord-335975-m6lkrehi 2968 14 creatinine creatinine NN cord-335975-m6lkrehi 2968 15 clearance clearance NN cord-335975-m6lkrehi 2968 16 ( ( -LRB- cord-335975-m6lkrehi 2968 17 CrCL CrCL NNP cord-335975-m6lkrehi 2968 18 ) ) -RRB- cord-335975-m6lkrehi 2968 19 measurements measurement NNS cord-335975-m6lkrehi 2968 20 and and CC cord-335975-m6lkrehi 2968 21 therapeutic therapeutic JJ cord-335975-m6lkrehi 2968 22 drug drug NN cord-335975-m6lkrehi 2968 23 monitoring monitoring NN cord-335975-m6lkrehi 2968 24 at at IN cord-335975-m6lkrehi 2968 25 trough trough NN cord-335975-m6lkrehi 2968 26 concentrations concentration NNS cord-335975-m6lkrehi 2968 27 . . . cord-335975-m6lkrehi 2969 1 The the DT cord-335975-m6lkrehi 2969 2 main main JJ cord-335975-m6lkrehi 2969 3 outcome outcome NN cord-335975-m6lkrehi 2969 4 investigated investigate VBN cord-335975-m6lkrehi 2969 5 in in IN cord-335975-m6lkrehi 2969 6 this this DT cord-335975-m6lkrehi 2969 7 study study NN cord-335975-m6lkrehi 2969 8 was be VBD cord-335975-m6lkrehi 2969 9 the the DT cord-335975-m6lkrehi 2969 10 rate rate NN cord-335975-m6lkrehi 2969 11 of of IN cord-335975-m6lkrehi 2969 12 empirical empirical JJ cord-335975-m6lkrehi 2969 13 target target NN cord-335975-m6lkrehi 2969 14 non non JJ cord-335975-m6lkrehi 2969 15 - - JJ cord-335975-m6lkrehi 2969 16 attainment attainment JJ cord-335975-m6lkrehi 2969 17 using use VBG cord-335975-m6lkrehi 2969 18 a a DT cord-335975-m6lkrehi 2969 19 theoretical theoretical JJ cord-335975-m6lkrehi 2969 20 target target NN cord-335975-m6lkrehi 2969 21 MIC mic NN cord-335975-m6lkrehi 2969 22 of of IN cord-335975-m6lkrehi 2969 23 2 2 CD cord-335975-m6lkrehi 2969 24 mg mg NNP cord-335975-m6lkrehi 2969 25 / / SYM cord-335975-m6lkrehi 2969 26 L. L. NNP cord-335975-m6lkrehi 2969 27 Results Results NNP cord-335975-m6lkrehi 2969 28 : : : cord-335975-m6lkrehi 2970 1 Over over IN cord-335975-m6lkrehi 2970 2 the the DT cord-335975-m6lkrehi 2970 3 study study NN cord-335975-m6lkrehi 2970 4 period period NN cord-335975-m6lkrehi 2970 5 , , , cord-335975-m6lkrehi 2970 6 21 21 CD cord-335975-m6lkrehi 2970 7 patients patient NNS cord-335975-m6lkrehi 2970 8 were be VBD cord-335975-m6lkrehi 2970 9 included include VBN cord-335975-m6lkrehi 2970 10 ( ( -LRB- cord-335975-m6lkrehi 2970 11 63 63 CD cord-335975-m6lkrehi 2970 12 samples sample NNS cord-335975-m6lkrehi 2970 13 analyzed analyze VBN cord-335975-m6lkrehi 2970 14 for for IN cord-335975-m6lkrehi 2970 15 therapeutic therapeutic JJ cord-335975-m6lkrehi 2970 16 drug drug NN cord-335975-m6lkrehi 2970 17 monitoring monitoring NN cord-335975-m6lkrehi 2970 18 ) ) -RRB- cord-335975-m6lkrehi 2970 19 . . . cord-335975-m6lkrehi 2971 1 The the DT cord-335975-m6lkrehi 2971 2 rate rate NN cord-335975-m6lkrehi 2971 3 of of IN cord-335975-m6lkrehi 2971 4 PK PK NNP cord-335975-m6lkrehi 2971 5 / / SYM cord-335975-m6lkrehi 2971 6 PD PD NNP cord-335975-m6lkrehi 2971 7 target target NN cord-335975-m6lkrehi 2971 8 non non JJ cord-335975-m6lkrehi 2971 9 - - JJ cord-335975-m6lkrehi 2971 10 attainment attainment JJ cord-335975-m6lkrehi 2971 11 was be VBD cord-335975-m6lkrehi 2971 12 62 62 CD cord-335975-m6lkrehi 2971 13 % % NN cord-335975-m6lkrehi 2971 14 , , , cord-335975-m6lkrehi 2971 15 with with IN cord-335975-m6lkrehi 2971 16 a a DT cord-335975-m6lkrehi 2971 17 strong strong JJ cord-335975-m6lkrehi 2971 18 association association NN cord-335975-m6lkrehi 2971 19 with with IN cord-335975-m6lkrehi 2971 20 CrCL CrCL NNP cord-335975-m6lkrehi 2971 21 ( ( -LRB- cord-335975-m6lkrehi 2971 22 p p NN cord-335975-m6lkrehi 2971 23 < < XX cord-335975-m6lkrehi 2971 24 0.0001 0.0001 CD cord-335975-m6lkrehi 2971 25 ) ) -RRB- cord-335975-m6lkrehi 2972 1 ( ( -LRB- cord-335975-m6lkrehi 2972 2 Table table NN cord-335975-m6lkrehi 2972 3 1 1 CD cord-335975-m6lkrehi 2972 4 ) ) -RRB- cord-335975-m6lkrehi 2972 5 . . . cord-335975-m6lkrehi 2973 1 There there EX cord-335975-m6lkrehi 2973 2 was be VBD cord-335975-m6lkrehi 2973 3 no no DT cord-335975-m6lkrehi 2973 4 statistical statistical JJ cord-335975-m6lkrehi 2973 5 association association NN cord-335975-m6lkrehi 2973 6 between between IN cord-335975-m6lkrehi 2973 7 PK/ pk/ PRP$ cord-335975-m6lkrehi 2973 8 PD PD NNP cord-335975-m6lkrehi 2973 9 target target NN cord-335975-m6lkrehi 2973 10 non non JJ cord-335975-m6lkrehi 2973 11 - - JJ cord-335975-m6lkrehi 2973 12 attainment attainment JJ cord-335975-m6lkrehi 2973 13 and and CC cord-335975-m6lkrehi 2973 14 therapeutic therapeutic JJ cord-335975-m6lkrehi 2973 15 failure failure NN cord-335975-m6lkrehi 2973 16 . . . cord-335975-m6lkrehi 2974 1 Conclusion conclusion NN cord-335975-m6lkrehi 2974 2 : : : cord-335975-m6lkrehi 2974 3 When when WRB cord-335975-m6lkrehi 2974 4 targeting target VBG cord-335975-m6lkrehi 2974 5 100%fT 100%ft CD cord-335975-m6lkrehi 2974 6 > > NFP cord-335975-m6lkrehi 2974 7 MIC mic NN cord-335975-m6lkrehi 2974 8 of of IN cord-335975-m6lkrehi 2974 9 the the DT cord-335975-m6lkrehi 2974 10 less less RBR cord-335975-m6lkrehi 2974 11 susceptible susceptible JJ cord-335975-m6lkrehi 2974 12 pathogens pathogen NNS cord-335975-m6lkrehi 2974 13 , , , cord-335975-m6lkrehi 2974 14 patients patient NNS cord-335975-m6lkrehi 2974 15 with with IN cord-335975-m6lkrehi 2974 16 CrCL CrCL NNP cord-335975-m6lkrehi 2974 17 > > XX cord-335975-m6lkrehi 2974 18 150 150 CD cord-335975-m6lkrehi 2974 19 mL ml NN cord-335975-m6lkrehi 2974 20 / / SYM cord-335975-m6lkrehi 2974 21 min min NN cord-335975-m6lkrehi 2974 22 are be VBP cord-335975-m6lkrehi 2974 23 at at IN cord-335975-m6lkrehi 2974 24 risk risk NN cord-335975-m6lkrehi 2974 25 of of IN cord-335975-m6lkrehi 2974 26 subexposure subexposure NN cord-335975-m6lkrehi 2974 27 in in IN cord-335975-m6lkrehi 2974 28 ceftriaxone ceftriaxone NNP cord-335975-m6lkrehi 2974 29 ( ( -LRB- cord-335975-m6lkrehi 2974 30 2 2 CD cord-335975-m6lkrehi 2974 31 g g NN cord-335975-m6lkrehi 2974 32 day day NN cord-335975-m6lkrehi 2974 33 ) ) -RRB- cord-335975-m6lkrehi 2974 34 . . . cord-335975-m6lkrehi 2975 1 These these DT cord-335975-m6lkrehi 2975 2 data datum NNS cord-335975-m6lkrehi 2975 3 emphasize emphasize VBP cord-335975-m6lkrehi 2975 4 the the DT cord-335975-m6lkrehi 2975 5 need need NN cord-335975-m6lkrehi 2975 6 of of IN cord-335975-m6lkrehi 2975 7 therapeutic therapeutic JJ cord-335975-m6lkrehi 2975 8 drug drug NN cord-335975-m6lkrehi 2975 9 monitoring monitoring NN cord-335975-m6lkrehi 2975 10 in in IN cord-335975-m6lkrehi 2975 11 patients patient NNS cord-335975-m6lkrehi 2975 12 with with IN cord-335975-m6lkrehi 2975 13 ARC ARC NNP cord-335975-m6lkrehi 2975 14 , , , cord-335975-m6lkrehi 2975 15 especially especially RB cord-335975-m6lkrehi 2975 16 when when WRB cord-335975-m6lkrehi 2975 17 targeting target VBG cord-335975-m6lkrehi 2975 18 less less RBR cord-335975-m6lkrehi 2975 19 susceptible susceptible JJ cord-335975-m6lkrehi 2975 20 pathogens pathogen NNS cord-335975-m6lkrehi 2975 21 or or CC cord-335975-m6lkrehi 2975 22 surgical surgical JJ cord-335975-m6lkrehi 2975 23 infections infection NNS cord-335975-m6lkrehi 2975 24 with with IN cord-335975-m6lkrehi 2975 25 limited limited JJ cord-335975-m6lkrehi 2975 26 penetration penetration NN cord-335975-m6lkrehi 2975 27 of of IN cord-335975-m6lkrehi 2975 28 antimicrobial antimicrobial JJ cord-335975-m6lkrehi 2975 29 agents agent NNS cord-335975-m6lkrehi 2975 30 . . . cord-335975-m6lkrehi 2976 1 Introduction introduction NN cord-335975-m6lkrehi 2976 2 : : : cord-335975-m6lkrehi 2977 1 The the DT cord-335975-m6lkrehi 2977 2 septic septic JJ cord-335975-m6lkrehi 2977 3 shock shock NN cord-335975-m6lkrehi 2977 4 is be VBZ cord-335975-m6lkrehi 2977 5 a a DT cord-335975-m6lkrehi 2977 6 major major JJ cord-335975-m6lkrehi 2977 7 concern concern NN cord-335975-m6lkrehi 2977 8 of of IN cord-335975-m6lkrehi 2977 9 the the DT cord-335975-m6lkrehi 2977 10 intensive intensive JJ cord-335975-m6lkrehi 2977 11 care care NN cord-335975-m6lkrehi 2977 12 unit unit NN cord-335975-m6lkrehi 2977 13 in in IN cord-335975-m6lkrehi 2977 14 the the DT cord-335975-m6lkrehi 2977 15 world world NN cord-335975-m6lkrehi 2977 16 because because IN cord-335975-m6lkrehi 2977 17 of of IN cord-335975-m6lkrehi 2977 18 its -PRON- PRP$ cord-335975-m6lkrehi 2977 19 frequency frequency NN cord-335975-m6lkrehi 2977 20 and and CC cord-335975-m6lkrehi 2977 21 especially especially RB cord-335975-m6lkrehi 2977 22 of of IN cord-335975-m6lkrehi 2977 23 its -PRON- PRP$ cord-335975-m6lkrehi 2977 24 mortality mortality NN cord-335975-m6lkrehi 2977 25 which which WDT cord-335975-m6lkrehi 2977 26 remains remain VBZ cord-335975-m6lkrehi 2977 27 high high JJ cord-335975-m6lkrehi 2977 28 in in IN cord-335975-m6lkrehi 2977 29 spite spite NN cord-335975-m6lkrehi 2977 30 of of IN cord-335975-m6lkrehi 2977 31 the the DT cord-335975-m6lkrehi 2977 32 progress progress NN cord-335975-m6lkrehi 2977 33 made make VBN cord-335975-m6lkrehi 2977 34 in in IN cord-335975-m6lkrehi 2977 35 the the DT cord-335975-m6lkrehi 2977 36 optimizing optimize VBG cord-335975-m6lkrehi 2977 37 care care NN cord-335975-m6lkrehi 2977 38 . . . cord-335975-m6lkrehi 2978 1 The the DT cord-335975-m6lkrehi 2978 2 aim aim NN cord-335975-m6lkrehi 2978 3 of of IN cord-335975-m6lkrehi 2978 4 our -PRON- PRP$ cord-335975-m6lkrehi 2978 5 work work NN cord-335975-m6lkrehi 2978 6 is be VBZ cord-335975-m6lkrehi 2978 7 to to TO cord-335975-m6lkrehi 2978 8 analyze analyze VB cord-335975-m6lkrehi 2978 9 the the DT cord-335975-m6lkrehi 2978 10 prognosis prognosis NN cord-335975-m6lkrehi 2978 11 factors factor NNS cord-335975-m6lkrehi 2978 12 related relate VBN cord-335975-m6lkrehi 2978 13 to to IN cord-335975-m6lkrehi 2978 14 death death NN cord-335975-m6lkrehi 2978 15 among among IN cord-335975-m6lkrehi 2978 16 patients patient NNS cord-335975-m6lkrehi 2978 17 with with IN cord-335975-m6lkrehi 2978 18 septic septic JJ cord-335975-m6lkrehi 2978 19 shock shock NN cord-335975-m6lkrehi 2978 20 in in IN cord-335975-m6lkrehi 2978 21 the the DT cord-335975-m6lkrehi 2978 22 ICU ICU NNP cord-335975-m6lkrehi 2978 23 of of IN cord-335975-m6lkrehi 2978 24 the the DT cord-335975-m6lkrehi 2978 25 military military JJ cord-335975-m6lkrehi 2978 26 hospital hospital NN cord-335975-m6lkrehi 2978 27 Avicenna Avicenna NNP cord-335975-m6lkrehi 2978 28 of of IN cord-335975-m6lkrehi 2978 29 Marrakesh Marrakesh NNP cord-335975-m6lkrehi 2978 30 , , , cord-335975-m6lkrehi 2978 31 and and CC cord-335975-m6lkrehi 2978 32 to to TO cord-335975-m6lkrehi 2978 33 focus focus VB cord-335975-m6lkrehi 2978 34 on on IN cord-335975-m6lkrehi 2978 35 the the DT cord-335975-m6lkrehi 2978 36 physiopathological physiopathological JJ cord-335975-m6lkrehi 2978 37 and and CC cord-335975-m6lkrehi 2978 38 therapeutic therapeutic JJ cord-335975-m6lkrehi 2978 39 data datum NNS cord-335975-m6lkrehi 2978 40 of of IN cord-335975-m6lkrehi 2978 41 the the DT cord-335975-m6lkrehi 2978 42 septic septic JJ cord-335975-m6lkrehi 2978 43 shock shock NN cord-335975-m6lkrehi 2978 44 in in IN cord-335975-m6lkrehi 2978 45 the the DT cord-335975-m6lkrehi 2978 46 light light NN cord-335975-m6lkrehi 2978 47 of of IN cord-335975-m6lkrehi 2978 48 last last JJ cord-335975-m6lkrehi 2978 49 acquisitions acquisition NNS cord-335975-m6lkrehi 2978 50 in in IN cord-335975-m6lkrehi 2978 51 this this DT cord-335975-m6lkrehi 2978 52 field field NN cord-335975-m6lkrehi 2978 53 . . . cord-335975-m6lkrehi 2979 1 Patients patient NNS cord-335975-m6lkrehi 2979 2 and and CC cord-335975-m6lkrehi 2979 3 methods method NNS cord-335975-m6lkrehi 2979 4 : : : cord-335975-m6lkrehi 2979 5 We -PRON- PRP cord-335975-m6lkrehi 2979 6 proceed proceed VBP cord-335975-m6lkrehi 2979 7 to to IN cord-335975-m6lkrehi 2979 8 a a DT cord-335975-m6lkrehi 2979 9 prospective prospective JJ cord-335975-m6lkrehi 2979 10 study study NN cord-335975-m6lkrehi 2979 11 including include VBG cord-335975-m6lkrehi 2979 12 all all DT cord-335975-m6lkrehi 2979 13 patients patient NNS cord-335975-m6lkrehi 2979 14 with with IN cord-335975-m6lkrehi 2979 15 septic septic JJ cord-335975-m6lkrehi 2979 16 shock shock NN cord-335975-m6lkrehi 2979 17 at at IN cord-335975-m6lkrehi 2979 18 admission admission NN cord-335975-m6lkrehi 2979 19 to to IN cord-335975-m6lkrehi 2979 20 ICU ICU NNP cord-335975-m6lkrehi 2979 21 or or CC cord-335975-m6lkrehi 2979 22 secondary secondary JJ cord-335975-m6lkrehi 2979 23 , , , cord-335975-m6lkrehi 2979 24 over over IN cord-335975-m6lkrehi 2979 25 a a DT cord-335975-m6lkrehi 2979 26 3-year 3-year CD cord-335975-m6lkrehi 2979 27 period period NN cord-335975-m6lkrehi 2979 28 ( ( -LRB- cord-335975-m6lkrehi 2979 29 January January NNP cord-335975-m6lkrehi 2979 30 2014 2014 CD cord-335975-m6lkrehi 2979 31 -December -December NNP cord-335975-m6lkrehi 2979 32 2016 2016 CD cord-335975-m6lkrehi 2979 33 ) ) -RRB- cord-335975-m6lkrehi 2979 34 . . . cord-335975-m6lkrehi 2980 1 Prognosis prognosis NN cord-335975-m6lkrehi 2980 2 factors factor NNS cord-335975-m6lkrehi 2980 3 related relate VBN cord-335975-m6lkrehi 2980 4 to to IN cord-335975-m6lkrehi 2980 5 death death NN cord-335975-m6lkrehi 2980 6 in in IN cord-335975-m6lkrehi 2980 7 patients patient NNS cord-335975-m6lkrehi 2980 8 with with IN cord-335975-m6lkrehi 2980 9 septic septic JJ cord-335975-m6lkrehi 2980 10 shock shock NN cord-335975-m6lkrehi 2980 11 were be VBD cord-335975-m6lkrehi 2980 12 studied study VBN cord-335975-m6lkrehi 2980 13 in in IN cord-335975-m6lkrehi 2980 14 univariate univariate JJ cord-335975-m6lkrehi 2980 15 and and CC cord-335975-m6lkrehi 2980 16 multivariate multivariate JJ cord-335975-m6lkrehi 2980 17 analysis analysis NN cord-335975-m6lkrehi 2980 18 . . . cord-335975-m6lkrehi 2981 1 Results result NNS cord-335975-m6lkrehi 2981 2 : : : cord-335975-m6lkrehi 2982 1 Eighty eighty CD cord-335975-m6lkrehi 2982 2 - - HYPH cord-335975-m6lkrehi 2982 3 six six CD cord-335975-m6lkrehi 2982 4 cases case NNS cord-335975-m6lkrehi 2982 5 of of IN cord-335975-m6lkrehi 2982 6 septic septic JJ cord-335975-m6lkrehi 2982 7 shock shock NN cord-335975-m6lkrehi 2982 8 were be VBD cord-335975-m6lkrehi 2982 9 collected collect VBN cord-335975-m6lkrehi 2982 10 from from IN cord-335975-m6lkrehi 2982 11 1290 1290 CD cord-335975-m6lkrehi 2982 12 ICU ICU NNP cord-335975-m6lkrehi 2982 13 admissions admission NNS cord-335975-m6lkrehi 2982 14 , , , cord-335975-m6lkrehi 2982 15 the the DT cord-335975-m6lkrehi 2982 16 incidence incidence NN cord-335975-m6lkrehi 2982 17 is be VBZ cord-335975-m6lkrehi 2982 18 3.33 3.33 CD cord-335975-m6lkrehi 2982 19 % % NN cord-335975-m6lkrehi 2982 20 , , , cord-335975-m6lkrehi 2982 21 the the DT cord-335975-m6lkrehi 2982 22 mean mean JJ cord-335975-m6lkrehi 2982 23 age age NN cord-335975-m6lkrehi 2982 24 was be VBD cord-335975-m6lkrehi 2982 25 58 58 CD cord-335975-m6lkrehi 2982 26 ± ± CD cord-335975-m6lkrehi 2982 27 14.7 14.7 CD cord-335975-m6lkrehi 2982 28 . . . cord-335975-m6lkrehi 2983 1 The the DT cord-335975-m6lkrehi 2983 2 sites site NNS cord-335975-m6lkrehi 2983 3 of of IN cord-335975-m6lkrehi 2983 4 infection infection NN cord-335975-m6lkrehi 2983 5 most most RBS cord-335975-m6lkrehi 2983 6 often often RB cord-335975-m6lkrehi 2983 7 involved involve VBN cord-335975-m6lkrehi 2983 8 were be VBD cord-335975-m6lkrehi 2983 9 the the DT cord-335975-m6lkrehi 2983 10 abdomen abdomen NN cord-335975-m6lkrehi 2983 11 and and CC cord-335975-m6lkrehi 2983 12 lung lung NN cord-335975-m6lkrehi 2983 13 ( ( -LRB- cord-335975-m6lkrehi 2983 14 50 50 CD cord-335975-m6lkrehi 2983 15 % % NN cord-335975-m6lkrehi 2983 16 ) ) -RRB- cord-335975-m6lkrehi 2983 17 , , , cord-335975-m6lkrehi 2983 18 there there EX cord-335975-m6lkrehi 2983 19 was be VBD cord-335975-m6lkrehi 2983 20 a a DT cord-335975-m6lkrehi 2983 21 predominance predominance NN cord-335975-m6lkrehi 2983 22 of of IN cord-335975-m6lkrehi 2983 23 Gram gram NN cord-335975-m6lkrehi 2983 24 - - HYPH cord-335975-m6lkrehi 2983 25 negative negative JJ cord-335975-m6lkrehi 2983 26 bacilli bacilli NN cord-335975-m6lkrehi 2983 27 , , , cord-335975-m6lkrehi 2983 28 the the DT cord-335975-m6lkrehi 2983 29 number number NN cord-335975-m6lkrehi 2983 30 of of IN cord-335975-m6lkrehi 2983 31 organ organ NN cord-335975-m6lkrehi 2983 32 failure failure NN cord-335975-m6lkrehi 2983 33 is be VBZ cord-335975-m6lkrehi 2983 34 in in IN cord-335975-m6lkrehi 2983 35 average average JJ cord-335975-m6lkrehi 2983 36 2.6 2.6 CD cord-335975-m6lkrehi 2983 37 ± ± CD cord-335975-m6lkrehi 2983 38 1.1 1.1 CD cord-335975-m6lkrehi 2983 39 . . . cord-335975-m6lkrehi 2984 1 The the DT cord-335975-m6lkrehi 2984 2 overall overall JJ cord-335975-m6lkrehi 2984 3 mortality mortality NN cord-335975-m6lkrehi 2984 4 was be VBD cord-335975-m6lkrehi 2984 5 65.1 65.1 CD cord-335975-m6lkrehi 2984 6 % % NN cord-335975-m6lkrehi 2984 7 . . . cord-335975-m6lkrehi 2985 1 Prognosis prognosis NN cord-335975-m6lkrehi 2985 2 factors factor NNS cord-335975-m6lkrehi 2985 3 related relate VBN cord-335975-m6lkrehi 2985 4 to to IN cord-335975-m6lkrehi 2985 5 mortality mortality NN cord-335975-m6lkrehi 2985 6 retained retain VBN cord-335975-m6lkrehi 2985 7 after after IN cord-335975-m6lkrehi 2985 8 logistic logistic JJ cord-335975-m6lkrehi 2985 9 regression regression NN cord-335975-m6lkrehi 2985 10 are be VBP cord-335975-m6lkrehi 2985 11 cardiovascular cardiovascular JJ cord-335975-m6lkrehi 2985 12 organ organ NN cord-335975-m6lkrehi 2985 13 failure failure NN cord-335975-m6lkrehi 2985 14 followed follow VBN cord-335975-m6lkrehi 2985 15 by by IN cord-335975-m6lkrehi 2985 16 neurological neurological JJ cord-335975-m6lkrehi 2985 17 . . . cord-335975-m6lkrehi 2986 1 Indeed indeed RB cord-335975-m6lkrehi 2986 2 , , , cord-335975-m6lkrehi 2986 3 the the DT cord-335975-m6lkrehi 2986 4 number number NN cord-335975-m6lkrehi 2986 5 of of IN cord-335975-m6lkrehi 2986 6 patients patient NNS cord-335975-m6lkrehi 2986 7 with with IN cord-335975-m6lkrehi 2986 8 3 3 CD cord-335975-m6lkrehi 2986 9 or or CC cord-335975-m6lkrehi 2986 10 more more JJR cord-335975-m6lkrehi 2986 11 failures failure NNS cord-335975-m6lkrehi 2986 12 was be VBD cord-335975-m6lkrehi 2986 13 22 22 CD cord-335975-m6lkrehi 2986 14 ( ( -LRB- cord-335975-m6lkrehi 2986 15 78 78 CD cord-335975-m6lkrehi 2986 16 % % NN cord-335975-m6lkrehi 2986 17 ) ) -RRB- cord-335975-m6lkrehi 2986 18 in in IN cord-335975-m6lkrehi 2986 19 the the DT cord-335975-m6lkrehi 2986 20 group group NN cord-335975-m6lkrehi 2986 21 of of IN cord-335975-m6lkrehi 2986 22 patients patient NNS cord-335975-m6lkrehi 2986 23 who who WP cord-335975-m6lkrehi 2986 24 died die VBD cord-335975-m6lkrehi 2986 25 . . . cord-335975-m6lkrehi 2987 1 As as IN cord-335975-m6lkrehi 2987 2 the the DT cord-335975-m6lkrehi 2987 3 second second JJ cord-335975-m6lkrehi 2987 4 factor factor NN cord-335975-m6lkrehi 2987 5 influencing influence VBG cord-335975-m6lkrehi 2987 6 the the DT cord-335975-m6lkrehi 2987 7 high high JJ cord-335975-m6lkrehi 2987 8 mortality mortality NN cord-335975-m6lkrehi 2987 9 found find VBD cord-335975-m6lkrehi 2987 10 severity severity NN cord-335975-m6lkrehi 2987 11 score score NN cord-335975-m6lkrehi 2987 12 53.6 53.6 CD cord-335975-m6lkrehi 2987 13 ± ± CD cord-335975-m6lkrehi 2987 14 14.7 14.7 CD cord-335975-m6lkrehi 2987 15 , , , cord-335975-m6lkrehi 2987 16 age age NN cord-335975-m6lkrehi 2987 17 is be VBZ cord-335975-m6lkrehi 2987 18 also also RB cord-335975-m6lkrehi 2987 19 considered consider VBN cord-335975-m6lkrehi 2987 20 a a DT cord-335975-m6lkrehi 2987 21 prognosis prognosis NN cord-335975-m6lkrehi 2987 22 factor factor NN cord-335975-m6lkrehi 2987 23 since since IN cord-335975-m6lkrehi 2987 24 21 21 CD cord-335975-m6lkrehi 2987 25 of of IN cord-335975-m6lkrehi 2987 26 28 28 CD cord-335975-m6lkrehi 2987 27 patients patient NNS cord-335975-m6lkrehi 2987 28 were be VBD cord-335975-m6lkrehi 2987 29 over over IN cord-335975-m6lkrehi 2987 30 60 60 CD cord-335975-m6lkrehi 2987 31 years year NNS cord-335975-m6lkrehi 2987 32 . . . cord-335975-m6lkrehi 2988 1 The the DT cord-335975-m6lkrehi 2988 2 average average JJ cord-335975-m6lkrehi 2988 3 age age NN cord-335975-m6lkrehi 2988 4 of of IN cord-335975-m6lkrehi 2988 5 the the DT cord-335975-m6lkrehi 2988 6 deceased deceased JJ cord-335975-m6lkrehi 2988 7 was be VBD cord-335975-m6lkrehi 2988 8 66 66 CD cord-335975-m6lkrehi 2988 9 ± ± CD cord-335975-m6lkrehi 2988 10 7 7 CD cord-335975-m6lkrehi 2988 11 years year NNS cord-335975-m6lkrehi 2988 12 versus versus IN cord-335975-m6lkrehi 2988 13 51 51 CD cord-335975-m6lkrehi 2988 14 ± ± CD cord-335975-m6lkrehi 2988 15 7 7 CD cord-335975-m6lkrehi 2988 16 years year NNS cord-335975-m6lkrehi 2988 17 in in IN cord-335975-m6lkrehi 2988 18 survivors survivor NNS cord-335975-m6lkrehi 2988 19 ( ( -LRB- cord-335975-m6lkrehi 2988 20 p p NN cord-335975-m6lkrehi 2988 21 < < XX cord-335975-m6lkrehi 2988 22 0.001 0.001 CD cord-335975-m6lkrehi 2988 23 ) ) -RRB- cord-335975-m6lkrehi 2988 24 , , , cord-335975-m6lkrehi 2988 25 yet yet CC cord-335975-m6lkrehi 2988 26 the the DT cord-335975-m6lkrehi 2988 27 mortality mortality NN cord-335975-m6lkrehi 2988 28 according accord VBG cord-335975-m6lkrehi 2988 29 to to IN cord-335975-m6lkrehi 2988 30 the the DT cord-335975-m6lkrehi 2988 31 infectious infectious JJ cord-335975-m6lkrehi 2988 32 agent agent NN cord-335975-m6lkrehi 2988 33 was be VBD cord-335975-m6lkrehi 2988 34 not not RB cord-335975-m6lkrehi 2988 35 found find VBN cord-335975-m6lkrehi 2988 36 as as IN cord-335975-m6lkrehi 2988 37 factor factor NN cord-335975-m6lkrehi 2988 38 influencing influence VBG cord-335975-m6lkrehi 2988 39 mortality mortality NN cord-335975-m6lkrehi 2988 40 ( ( -LRB- cord-335975-m6lkrehi 2988 41 p p NN cord-335975-m6lkrehi 2988 42 = = SYM cord-335975-m6lkrehi 2988 43 0.75 0.75 CD cord-335975-m6lkrehi 2988 44 ) ) -RRB- cord-335975-m6lkrehi 2988 45 . . . cord-335975-m6lkrehi 2989 1 Conclusion conclusion NN cord-335975-m6lkrehi 2989 2 : : : cord-335975-m6lkrehi 2990 1 Septic septic JJ cord-335975-m6lkrehi 2990 2 shock shock NN cord-335975-m6lkrehi 2990 3 is be VBZ cord-335975-m6lkrehi 2990 4 a a DT cord-335975-m6lkrehi 2990 5 frequent frequent JJ cord-335975-m6lkrehi 2990 6 reason reason NN cord-335975-m6lkrehi 2990 7 for for IN cord-335975-m6lkrehi 2990 8 hospitalization hospitalization NN cord-335975-m6lkrehi 2990 9 in in IN cord-335975-m6lkrehi 2990 10 ICU ICU NNP cord-335975-m6lkrehi 2990 11 . . . cord-335975-m6lkrehi 2991 1 The the DT cord-335975-m6lkrehi 2991 2 improvement improvement NN cord-335975-m6lkrehi 2991 3 of of IN cord-335975-m6lkrehi 2991 4 prognosis prognosis NN cord-335975-m6lkrehi 2991 5 requires require VBZ cord-335975-m6lkrehi 2991 6 an an DT cord-335975-m6lkrehi 2991 7 early early JJ cord-335975-m6lkrehi 2991 8 and and CC cord-335975-m6lkrehi 2991 9 adapted adapt VBN cord-335975-m6lkrehi 2991 10 management management NN cord-335975-m6lkrehi 2991 11 of of IN cord-335975-m6lkrehi 2991 12 sepsis sepsis NN cord-335975-m6lkrehi 2991 13 as as RB cord-335975-m6lkrehi 2991 14 well well RB cord-335975-m6lkrehi 2991 15 as as IN cord-335975-m6lkrehi 2991 16 increases increase VBZ cord-335975-m6lkrehi 2991 17 efforts effort NNS cord-335975-m6lkrehi 2991 18 for for IN cord-335975-m6lkrehi 2991 19 control control NN cord-335975-m6lkrehi 2991 20 and and CC cord-335975-m6lkrehi 2991 21 prevention prevention NN cord-335975-m6lkrehi 2991 22 of of IN cord-335975-m6lkrehi 2991 23 nosocomial nosocomial JJ cord-335975-m6lkrehi 2991 24 infection infection NN cord-335975-m6lkrehi 2991 25 . . . cord-335975-m6lkrehi 2992 1 Introduction introduction NN cord-335975-m6lkrehi 2992 2 : : : cord-335975-m6lkrehi 2993 1 Vitamin vitamin NN cord-335975-m6lkrehi 2993 2 D d NN cord-335975-m6lkrehi 2993 3 deficiency deficiency NN cord-335975-m6lkrehi 2993 4 is be VBZ cord-335975-m6lkrehi 2993 5 common common JJ cord-335975-m6lkrehi 2993 6 in in IN cord-335975-m6lkrehi 2993 7 critically critically RB cord-335975-m6lkrehi 2993 8 - - HYPH cord-335975-m6lkrehi 2993 9 ill ill JJ cord-335975-m6lkrehi 2993 10 patients patient NNS cord-335975-m6lkrehi 2993 11 . . . cord-335975-m6lkrehi 2994 1 In in IN cord-335975-m6lkrehi 2994 2 addition addition NN cord-335975-m6lkrehi 2994 3 to to IN cord-335975-m6lkrehi 2994 4 its -PRON- PRP$ cord-335975-m6lkrehi 2994 5 role role NN cord-335975-m6lkrehi 2994 6 in in IN cord-335975-m6lkrehi 2994 7 the the DT cord-335975-m6lkrehi 2994 8 regulation regulation NN cord-335975-m6lkrehi 2994 9 of of IN cord-335975-m6lkrehi 2994 10 phosphor phosphor NN cord-335975-m6lkrehi 2994 11 - - HYPH cord-335975-m6lkrehi 2994 12 calcic calcic NN cord-335975-m6lkrehi 2994 13 metabolism metabolism NN cord-335975-m6lkrehi 2994 14 , , , cord-335975-m6lkrehi 2994 15 vitamin vitamin NN cord-335975-m6lkrehi 2994 16 D d NN cord-335975-m6lkrehi 2994 17 is be VBZ cord-335975-m6lkrehi 2994 18 of of IN cord-335975-m6lkrehi 2994 19 paramount paramount JJ cord-335975-m6lkrehi 2994 20 importance importance NN cord-335975-m6lkrehi 2994 21 for for IN cord-335975-m6lkrehi 2994 22 the the DT cord-335975-m6lkrehi 2994 23 immune immune JJ cord-335975-m6lkrehi 2994 24 system system NN cord-335975-m6lkrehi 2994 25 . . . cord-335975-m6lkrehi 2995 1 The the DT cord-335975-m6lkrehi 2995 2 aim aim NN cord-335975-m6lkrehi 2995 3 of of IN cord-335975-m6lkrehi 2995 4 the the DT cord-335975-m6lkrehi 2995 5 current current JJ cord-335975-m6lkrehi 2995 6 study study NN cord-335975-m6lkrehi 2995 7 is be VBZ cord-335975-m6lkrehi 2995 8 to to TO cord-335975-m6lkrehi 2995 9 assess assess VB cord-335975-m6lkrehi 2995 10 the the DT cord-335975-m6lkrehi 2995 11 prognostic prognostic JJ cord-335975-m6lkrehi 2995 12 value value NN cord-335975-m6lkrehi 2995 13 of of IN cord-335975-m6lkrehi 2995 14 vitamin vitamin NN cord-335975-m6lkrehi 2995 15 D d NN cord-335975-m6lkrehi 2995 16 deficiency deficiency NN cord-335975-m6lkrehi 2995 17 in in IN cord-335975-m6lkrehi 2995 18 patients patient NNS cord-335975-m6lkrehi 2995 19 with with IN cord-335975-m6lkrehi 2995 20 septic septic JJ cord-335975-m6lkrehi 2995 21 shock shock NN cord-335975-m6lkrehi 2995 22 . . . cord-335975-m6lkrehi 2996 1 Patients patient NNS cord-335975-m6lkrehi 2996 2 and and CC cord-335975-m6lkrehi 2996 3 methods method NNS cord-335975-m6lkrehi 2996 4 : : : cord-335975-m6lkrehi 2996 5 Retrospective retrospective JJ cord-335975-m6lkrehi 2996 6 study study NN cord-335975-m6lkrehi 2996 7 conducted conduct VBN cord-335975-m6lkrehi 2996 8 over over IN cord-335975-m6lkrehi 2996 9 6 6 CD cord-335975-m6lkrehi 2996 10 months month NNS cord-335975-m6lkrehi 2996 11 . . . cord-335975-m6lkrehi 2997 1 All all PDT cord-335975-m6lkrehi 2997 2 the the DT cord-335975-m6lkrehi 2997 3 adult adult NN cord-335975-m6lkrehi 2997 4 patients patient NNS cord-335975-m6lkrehi 2997 5 with with IN cord-335975-m6lkrehi 2997 6 septic septic JJ cord-335975-m6lkrehi 2997 7 shock shock NN cord-335975-m6lkrehi 2997 8 and and CC cord-335975-m6lkrehi 2997 9 vitamin vitamin NN cord-335975-m6lkrehi 2997 10 D d NN cord-335975-m6lkrehi 2997 11 level level NN cord-335975-m6lkrehi 2997 12 screening screening NN cord-335975-m6lkrehi 2997 13 performed perform VBN cord-335975-m6lkrehi 2997 14 within within IN cord-335975-m6lkrehi 2997 15 the the DT cord-335975-m6lkrehi 2997 16 first first JJ cord-335975-m6lkrehi 2997 17 24 24 CD cord-335975-m6lkrehi 2997 18 h h NN cord-335975-m6lkrehi 2997 19 of of IN cord-335975-m6lkrehi 2997 20 admission admission NN cord-335975-m6lkrehi 2997 21 were be VBD cord-335975-m6lkrehi 2997 22 included include VBN cord-335975-m6lkrehi 2997 23 in in IN cord-335975-m6lkrehi 2997 24 the the DT cord-335975-m6lkrehi 2997 25 study study NN cord-335975-m6lkrehi 2997 26 . . . cord-335975-m6lkrehi 2998 1 We -PRON- PRP cord-335975-m6lkrehi 2998 2 excluded exclude VBD cord-335975-m6lkrehi 2998 3 patients patient NNS cord-335975-m6lkrehi 2998 4 with with IN cord-335975-m6lkrehi 2998 5 chronic chronic JJ cord-335975-m6lkrehi 2998 6 kidney kidney NN cord-335975-m6lkrehi 2998 7 disease disease NN cord-335975-m6lkrehi 2998 8 and and CC cord-335975-m6lkrehi 2998 9 those those DT cord-335975-m6lkrehi 2998 10 receiving receive VBG cord-335975-m6lkrehi 2998 11 vitamin vitamin NN cord-335975-m6lkrehi 2998 12 D d NN cord-335975-m6lkrehi 2998 13 supply supply NN cord-335975-m6lkrehi 2998 14 . . . cord-335975-m6lkrehi 2999 1 Two two CD cord-335975-m6lkrehi 2999 2 groups group NNS cord-335975-m6lkrehi 2999 3 were be VBD cord-335975-m6lkrehi 2999 4 compared compare VBN cord-335975-m6lkrehi 2999 5 : : : cord-335975-m6lkrehi 2999 6 those those DT cord-335975-m6lkrehi 2999 7 with with IN cord-335975-m6lkrehi 2999 8 a a DT cord-335975-m6lkrehi 2999 9 serum serum NN cord-335975-m6lkrehi 2999 10 Vitamin vitamin NN cord-335975-m6lkrehi 2999 11 D d NN cord-335975-m6lkrehi 2999 12 level level NN cord-335975-m6lkrehi 2999 13 < < XX cord-335975-m6lkrehi 2999 14 10 10 CD cord-335975-m6lkrehi 2999 15 ng ng NNP cord-335975-m6lkrehi 2999 16 / / SYM cord-335975-m6lkrehi 2999 17 ml ml NN cord-335975-m6lkrehi 2999 18 ( ( -LRB- cord-335975-m6lkrehi 2999 19 G1 G1 NNP cord-335975-m6lkrehi 2999 20 ) ) -RRB- cord-335975-m6lkrehi 2999 21 and and CC cord-335975-m6lkrehi 2999 22 those those DT cord-335975-m6lkrehi 2999 23 with with IN cord-335975-m6lkrehi 2999 24 higher high JJR cord-335975-m6lkrehi 2999 25 level level NN cord-335975-m6lkrehi 2999 26 ( ( -LRB- cord-335975-m6lkrehi 2999 27 G2 G2 NNP cord-335975-m6lkrehi 2999 28 Introduction introduction NN cord-335975-m6lkrehi 2999 29 : : : cord-335975-m6lkrehi 2999 30 Since since IN cord-335975-m6lkrehi 2999 31 immunity immunity NN cord-335975-m6lkrehi 2999 32 plays play VBZ cord-335975-m6lkrehi 2999 33 a a DT cord-335975-m6lkrehi 2999 34 central central JJ cord-335975-m6lkrehi 2999 35 role role NN cord-335975-m6lkrehi 2999 36 in in IN cord-335975-m6lkrehi 2999 37 neoplasms neoplasm NNS cord-335975-m6lkrehi 2999 38 surveillance surveillance NN cord-335975-m6lkrehi 2999 39 , , , cord-335975-m6lkrehi 2999 40 it -PRON- PRP cord-335975-m6lkrehi 2999 41 is be VBZ cord-335975-m6lkrehi 2999 42 likely likely JJ cord-335975-m6lkrehi 2999 43 that that IN cord-335975-m6lkrehi 2999 44 sepsis sepsis NN cord-335975-m6lkrehi 2999 45 induced induce VBD cord-335975-m6lkrehi 2999 46 immune immune JJ cord-335975-m6lkrehi 2999 47 dysfunctions dysfunction NNS cord-335975-m6lkrehi 2999 48 may may MD cord-335975-m6lkrehi 2999 49 impact impact VB cord-335975-m6lkrehi 2999 50 on on IN cord-335975-m6lkrehi 2999 51 the the DT cord-335975-m6lkrehi 2999 52 underlying underlie VBG cord-335975-m6lkrehi 2999 53 malignancy malignancy NN cord-335975-m6lkrehi 2999 54 . . . cord-335975-m6lkrehi 3000 1 We -PRON- PRP cord-335975-m6lkrehi 3000 2 developed develop VBD cord-335975-m6lkrehi 3000 3 a a DT cord-335975-m6lkrehi 3000 4 research research NN cord-335975-m6lkrehi 3000 5 project project NN cord-335975-m6lkrehi 3000 6 investigating investigate VBG cord-335975-m6lkrehi 3000 7 the the DT cord-335975-m6lkrehi 3000 8 reciprocal reciprocal JJ cord-335975-m6lkrehi 3000 9 relationships relationship NNS cord-335975-m6lkrehi 3000 10 between between IN cord-335975-m6lkrehi 3000 11 bacterial bacterial JJ cord-335975-m6lkrehi 3000 12 sepsis sepsis NN cord-335975-m6lkrehi 3000 13 and and CC cord-335975-m6lkrehi 3000 14 cancer cancer NN cord-335975-m6lkrehi 3000 15 . . . cord-335975-m6lkrehi 3001 1 We -PRON- PRP cord-335975-m6lkrehi 3001 2 reported report VBD cord-335975-m6lkrehi 3001 3 that that IN cord-335975-m6lkrehi 3001 4 sepsis sepsis NN cord-335975-m6lkrehi 3001 5 - - HYPH cord-335975-m6lkrehi 3001 6 induced induce VBN cord-335975-m6lkrehi 3001 7 immune immune JJ cord-335975-m6lkrehi 3001 8 suppression suppression NN cord-335975-m6lkrehi 3001 9 promoted promote VBD cord-335975-m6lkrehi 3001 10 tumor tumor NN cord-335975-m6lkrehi 3001 11 growth growth NN cord-335975-m6lkrehi 3001 12 in in IN cord-335975-m6lkrehi 3001 13 post post JJ cord-335975-m6lkrehi 3001 14 - - JJ cord-335975-m6lkrehi 3001 15 septic septic JJ cord-335975-m6lkrehi 3001 16 mice mouse NNS cord-335975-m6lkrehi 3001 17 inoculated inoculate VBN cord-335975-m6lkrehi 3001 18 with with IN cord-335975-m6lkrehi 3001 19 cancer cancer NN cord-335975-m6lkrehi 3001 20 . . . cord-335975-m6lkrehi 3002 1 In in IN cord-335975-m6lkrehi 3002 2 a a DT cord-335975-m6lkrehi 3002 3 reverse reverse JJ cord-335975-m6lkrehi 3002 4 cancer cancer NN cord-335975-m6lkrehi 3002 5 - - HYPH cord-335975-m6lkrehi 3002 6 then then RB cord-335975-m6lkrehi 3002 7 - - HYPH cord-335975-m6lkrehi 3002 8 sepsis sepsis NN cord-335975-m6lkrehi 3002 9 model model NN cord-335975-m6lkrehi 3002 10 we -PRON- PRP cord-335975-m6lkrehi 3002 11 observed observe VBD cord-335975-m6lkrehi 3002 12 that that IN cord-335975-m6lkrehi 3002 13 sepsis sepsis NN cord-335975-m6lkrehi 3002 14 may may MD cord-335975-m6lkrehi 3002 15 conversely conversely RB cord-335975-m6lkrehi 3002 16 inhibit inhibit VB cord-335975-m6lkrehi 3002 17 tumor tumor NN cord-335975-m6lkrehi 3002 18 growth growth NN cord-335975-m6lkrehi 3002 19 . . . cord-335975-m6lkrehi 3003 1 This this DT cord-335975-m6lkrehi 3003 2 study study NN cord-335975-m6lkrehi 3003 3 aimed aim VBN cord-335975-m6lkrehi 3003 4 at at IN cord-335975-m6lkrehi 3003 5 investigating investigate VBG cord-335975-m6lkrehi 3003 6 the the DT cord-335975-m6lkrehi 3003 7 cellular cellular JJ cord-335975-m6lkrehi 3003 8 and and CC cord-335975-m6lkrehi 3003 9 molecular molecular JJ cord-335975-m6lkrehi 3003 10 mechanisms mechanism NNS cord-335975-m6lkrehi 3003 11 of of IN cord-335975-m6lkrehi 3003 12 sepsis sepsis NN cord-335975-m6lkrehi 3003 13 - - HYPH cord-335975-m6lkrehi 3003 14 induced induce VBN cord-335975-m6lkrehi 3003 15 tumor tumor NN cord-335975-m6lkrehi 3003 16 inhibition inhibition NN cord-335975-m6lkrehi 3003 17 , , , cord-335975-m6lkrehi 3003 18 and and CC cord-335975-m6lkrehi 3003 19 most most JJS cord-335975-m6lkrehi 3003 20 especially especially RB cord-335975-m6lkrehi 3003 21 the the DT cord-335975-m6lkrehi 3003 22 role role NN cord-335975-m6lkrehi 3003 23 of of IN cord-335975-m6lkrehi 3003 24 monocytes monocyte NNS cord-335975-m6lkrehi 3003 25 macrophages macrophage NNS cord-335975-m6lkrehi 3003 26 and and CC cord-335975-m6lkrehi 3003 27 Toll toll NN cord-335975-m6lkrehi 3003 28 - - HYPH cord-335975-m6lkrehi 3003 29 like like JJ cord-335975-m6lkrehi 3003 30 receptor receptor NN cord-335975-m6lkrehi 3003 31 ( ( -LRB- cord-335975-m6lkrehi 3003 32 Tlr tlr NN cord-335975-m6lkrehi 3003 33 ) ) -RRB- cord-335975-m6lkrehi 3003 34 signaling signaling NN cord-335975-m6lkrehi 3003 35 . . . cord-335975-m6lkrehi 3004 1 Patients patient NNS cord-335975-m6lkrehi 3004 2 and and CC cord-335975-m6lkrehi 3004 3 methods method NNS cord-335975-m6lkrehi 3005 1 : : : cord-335975-m6lkrehi 3005 2 We -PRON- PRP cord-335975-m6lkrehi 3005 3 used use VBD cord-335975-m6lkrehi 3005 4 C57BL c57bl NN cord-335975-m6lkrehi 3005 5 6 6 CD cord-335975-m6lkrehi 3005 6 J J NNP cord-335975-m6lkrehi 3005 7 wild wild JJ cord-335975-m6lkrehi 3005 8 - - HYPH cord-335975-m6lkrehi 3005 9 type type NN cord-335975-m6lkrehi 3005 10 ( ( -LRB- cord-335975-m6lkrehi 3005 11 WT WT NNP cord-335975-m6lkrehi 3005 12 ) ) -RRB- cord-335975-m6lkrehi 3005 13 , , , cord-335975-m6lkrehi 3005 14 Tlr4-/- Tlr4-/- NNP cord-335975-m6lkrehi 3005 15 , , , cord-335975-m6lkrehi 3005 16 Tlr2-/-and Tlr2-/-and NNP cord-335975-m6lkrehi 3005 17 Myd88-/-mice Myd88-/-mice NNP cord-335975-m6lkrehi 3005 18 . . . cord-335975-m6lkrehi 3006 1 Mice mouse NNS cord-335975-m6lkrehi 3006 2 were be VBD cord-335975-m6lkrehi 3006 3 first first RB cord-335975-m6lkrehi 3006 4 subjected subject VBN cord-335975-m6lkrehi 3006 5 to to IN cord-335975-m6lkrehi 3006 6 tumor tumor NN cord-335975-m6lkrehi 3006 7 inoculation inoculation NN cord-335975-m6lkrehi 3006 8 by by IN cord-335975-m6lkrehi 3006 9 subcutaneous subcutaneous JJ cord-335975-m6lkrehi 3006 10 injection injection NN cord-335975-m6lkrehi 3006 11 of of IN cord-335975-m6lkrehi 3006 12 MCA205 MCA205 NNP cord-335975-m6lkrehi 3006 13 fibrosarcoma fibrosarcoma NNS cord-335975-m6lkrehi 3006 14 cells cell NNS cord-335975-m6lkrehi 3006 15 . . . cord-335975-m6lkrehi 3007 1 Fourteen fourteen CD cord-335975-m6lkrehi 3007 2 days day NNS cord-335975-m6lkrehi 3007 3 after after RB cord-335975-m6lkrehi 3007 4 , , , cord-335975-m6lkrehi 3007 5 mice mouse NNS cord-335975-m6lkrehi 3007 6 were be VBD cord-335975-m6lkrehi 3007 7 subjected subject VBN cord-335975-m6lkrehi 3007 8 to to IN cord-335975-m6lkrehi 3007 9 polymicrobial polymicrobial JJ cord-335975-m6lkrehi 3007 10 sepsis sepsis NN cord-335975-m6lkrehi 3007 11 induced induce VBN cord-335975-m6lkrehi 3007 12 by by IN cord-335975-m6lkrehi 3007 13 cecal cecal JJ cord-335975-m6lkrehi 3007 14 ligation ligation NN cord-335975-m6lkrehi 3007 15 and and CC cord-335975-m6lkrehi 3007 16 puncture puncture NN cord-335975-m6lkrehi 3007 17 ( ( -LRB- cord-335975-m6lkrehi 3007 18 CLP CLP NNP cord-335975-m6lkrehi 3007 19 ) ) -RRB- cord-335975-m6lkrehi 3007 20 . . . cord-335975-m6lkrehi 3008 1 Controls control NNS cord-335975-m6lkrehi 3008 2 were be VBD cord-335975-m6lkrehi 3008 3 cancer cancer NN cord-335975-m6lkrehi 3008 4 mice mouse NNS cord-335975-m6lkrehi 3008 5 subjected subject VBN cord-335975-m6lkrehi 3008 6 to to IN cord-335975-m6lkrehi 3008 7 sham sham NN cord-335975-m6lkrehi 3008 8 surgery surgery NN cord-335975-m6lkrehi 3008 9 . . . cord-335975-m6lkrehi 3009 1 Alternatively alternatively RB cord-335975-m6lkrehi 3009 2 , , , cord-335975-m6lkrehi 3009 3 cancer cancer NN cord-335975-m6lkrehi 3009 4 mice mouse NNS cord-335975-m6lkrehi 3009 5 were be VBD cord-335975-m6lkrehi 3009 6 subjected subject VBN cord-335975-m6lkrehi 3009 7 to to IN cord-335975-m6lkrehi 3009 8 an an DT cord-335975-m6lkrehi 3009 9 i.p i.p NNP cord-335975-m6lkrehi 3009 10 . . NNP cord-335975-m6lkrehi 3009 11 challenge challenge NN cord-335975-m6lkrehi 3009 12 with with IN cord-335975-m6lkrehi 3009 13 Tlr Tlr NNP cord-335975-m6lkrehi 3009 14 agonist agonist NN cord-335975-m6lkrehi 3009 15 ( ( -LRB- cord-335975-m6lkrehi 3009 16 LPS LPS NNP cord-335975-m6lkrehi 3009 17 or or CC cord-335975-m6lkrehi 3009 18 heat heat NN cord-335975-m6lkrehi 3009 19 - - HYPH cord-335975-m6lkrehi 3009 20 killed kill VBN cord-335975-m6lkrehi 3009 21 Staphylococcus Staphylococcus NNP cord-335975-m6lkrehi 3009 22 aureus aureus NN cord-335975-m6lkrehi 3009 23 ( ( -LRB- cord-335975-m6lkrehi 3009 24 HKSA HKSA NNP cord-335975-m6lkrehi 3009 25 ) ) -RRB- cord-335975-m6lkrehi 3009 26 ) ) -RRB- cord-335975-m6lkrehi 3009 27 . . . cord-335975-m6lkrehi 3010 1 The the DT cord-335975-m6lkrehi 3010 2 distribution distribution NN cord-335975-m6lkrehi 3010 3 of of IN cord-335975-m6lkrehi 3010 4 tumor tumor NN cord-335975-m6lkrehi 3010 5 - - HYPH cord-335975-m6lkrehi 3010 6 associated associate VBN cord-335975-m6lkrehi 3010 7 immune immune JJ cord-335975-m6lkrehi 3010 8 cells cell NNS cord-335975-m6lkrehi 3010 9 was be VBD cord-335975-m6lkrehi 3010 10 assessed assess VBN cord-335975-m6lkrehi 3010 11 by by IN cord-335975-m6lkrehi 3010 12 FACS FACS NNP cord-335975-m6lkrehi 3010 13 at at IN cord-335975-m6lkrehi 3010 14 days day NNS cord-335975-m6lkrehi 3010 15 1 1 CD cord-335975-m6lkrehi 3010 16 and and CC cord-335975-m6lkrehi 3010 17 7 7 CD cord-335975-m6lkrehi 3010 18 following follow VBG cord-335975-m6lkrehi 3010 19 surgery surgery NN cord-335975-m6lkrehi 3010 20 . . . cord-335975-m6lkrehi 3011 1 The the DT cord-335975-m6lkrehi 3011 2 activation activation NN cord-335975-m6lkrehi 3011 3 status status NN cord-335975-m6lkrehi 3011 4 of of IN cord-335975-m6lkrehi 3011 5 tumorinfiltrating tumorinfiltrating NN cord-335975-m6lkrehi 3011 6 monocytes monocyte NNS cord-335975-m6lkrehi 3011 7 macrophages macrophage NNS cord-335975-m6lkrehi 3011 8 was be VBD cord-335975-m6lkrehi 3011 9 assessed assess VBN cord-335975-m6lkrehi 3011 10 by by IN cord-335975-m6lkrehi 3011 11 FACS FACS NNP cord-335975-m6lkrehi 3011 12 ( ( -LRB- cord-335975-m6lkrehi 3011 13 MHCII MHCII NNP cord-335975-m6lkrehi 3011 14 , , , cord-335975-m6lkrehi 3011 15 CD40 CD40 NNP cord-335975-m6lkrehi 3011 16 , , , cord-335975-m6lkrehi 3011 17 CD86 CD86 NNP cord-335975-m6lkrehi 3011 18 , , , cord-335975-m6lkrehi 3011 19 PDL1 PDL1 NNP cord-335975-m6lkrehi 3011 20 , , , cord-335975-m6lkrehi 3011 21 PD1 PD1 NNP cord-335975-m6lkrehi 3011 22 ) ) -RRB- cord-335975-m6lkrehi 3011 23 . . . cord-335975-m6lkrehi 3012 1 F4/80 F4/80 NNS cord-335975-m6lkrehi 3013 1 + + CC cord-335975-m6lkrehi 3013 2 cells cell NNS cord-335975-m6lkrehi 3013 3 were be VBD cord-335975-m6lkrehi 3013 4 purified purify VBN cord-335975-m6lkrehi 3013 5 by by IN cord-335975-m6lkrehi 3013 6 FACS FACS NNP cord-335975-m6lkrehi 3014 1 and and CC cord-335975-m6lkrehi 3014 2 we -PRON- PRP cord-335975-m6lkrehi 3014 3 assessed assess VBD cord-335975-m6lkrehi 3014 4 cytokines cytokine NNS cord-335975-m6lkrehi 3014 5 production production NN cord-335975-m6lkrehi 3014 6 ( ( -LRB- cord-335975-m6lkrehi 3014 7 rt rt NNP cord-335975-m6lkrehi 3014 8 - - HYPH cord-335975-m6lkrehi 3014 9 qPCR qPCR NNP cord-335975-m6lkrehi 3014 10 ) ) -RRB- cord-335975-m6lkrehi 3014 11 and and CC cord-335975-m6lkrehi 3014 12 bacteria bacteria NNS cord-335975-m6lkrehi 3014 13 phagocytosis phagocytosis NN cord-335975-m6lkrehi 3014 14 . . . cord-335975-m6lkrehi 3014 15 _SP cord-335975-m6lkrehi 3015 1 We -PRON- PRP cord-335975-m6lkrehi 3015 2 confirmed confirm VBD cord-335975-m6lkrehi 3015 3 polymicrobial polymicrobial JJ cord-335975-m6lkrehi 3015 4 sepsis sepsis NN cord-335975-m6lkrehi 3015 5 dampens dampen VBZ cord-335975-m6lkrehi 3015 6 tumor tumor NN cord-335975-m6lkrehi 3015 7 growth growth NN cord-335975-m6lkrehi 3015 8 in in IN cord-335975-m6lkrehi 3015 9 WT WT NNP cord-335975-m6lkrehi 3015 10 mice mouse NNS cord-335975-m6lkrehi 3015 11 . . . cord-335975-m6lkrehi 3016 1 A a DT cord-335975-m6lkrehi 3016 2 similar similar JJ cord-335975-m6lkrehi 3016 3 CLP clp NN cord-335975-m6lkrehi 3016 4 - - HYPH cord-335975-m6lkrehi 3016 5 induced induce VBN cord-335975-m6lkrehi 3016 6 tumor tumor NN cord-335975-m6lkrehi 3016 7 growth growth NN cord-335975-m6lkrehi 3016 8 inhibition inhibition NN cord-335975-m6lkrehi 3016 9 was be VBD cord-335975-m6lkrehi 3016 10 observed observe VBN cord-335975-m6lkrehi 3016 11 in in IN cord-335975-m6lkrehi 3016 12 Tlr2-/-mice Tlr2-/-mice NNP cord-335975-m6lkrehi 3016 13 , , , cord-335975-m6lkrehi 3016 14 but but CC cord-335975-m6lkrehi 3016 15 neither neither CC cord-335975-m6lkrehi 3016 16 in in IN cord-335975-m6lkrehi 3016 17 Tlr4-/-nor Tlr4-/-nor NNP cord-335975-m6lkrehi 3016 18 Myd88-/-mice Myd88-/-mice NNP cord-335975-m6lkrehi 3016 19 . . . cord-335975-m6lkrehi 3017 1 A a DT cord-335975-m6lkrehi 3017 2 challenge challenge NN cord-335975-m6lkrehi 3017 3 with with IN cord-335975-m6lkrehi 3017 4 LPS LPS NNP cord-335975-m6lkrehi 3017 5 resulted result VBD cord-335975-m6lkrehi 3017 6 in in IN cord-335975-m6lkrehi 3017 7 a a DT cord-335975-m6lkrehi 3017 8 marked marked JJ cord-335975-m6lkrehi 3017 9 anti anti JJ cord-335975-m6lkrehi 3017 10 - - JJ cord-335975-m6lkrehi 3017 11 tumoral tumoral JJ cord-335975-m6lkrehi 3017 12 effect effect NN cord-335975-m6lkrehi 3017 13 , , , cord-335975-m6lkrehi 3017 14 whereas whereas IN cord-335975-m6lkrehi 3017 15 a a DT cord-335975-m6lkrehi 3017 16 challenge challenge NN cord-335975-m6lkrehi 3017 17 with with IN cord-335975-m6lkrehi 3017 18 HKSA HKSA NNP cord-335975-m6lkrehi 3017 19 had have VBD cord-335975-m6lkrehi 3017 20 no no DT cord-335975-m6lkrehi 3017 21 impact impact NN cord-335975-m6lkrehi 3017 22 on on IN cord-335975-m6lkrehi 3017 23 tumor tumor NN cord-335975-m6lkrehi 3017 24 growth growth NN cord-335975-m6lkrehi 3017 25 . . . cord-335975-m6lkrehi 3018 1 Tumor tumor NN cord-335975-m6lkrehi 3018 2 - - HYPH cord-335975-m6lkrehi 3018 3 infiltrating infiltrate VBG cord-335975-m6lkrehi 3018 4 immune immune JJ cord-335975-m6lkrehi 3018 5 cells cell NNS cord-335975-m6lkrehi 3018 6 analysis analysis NN cord-335975-m6lkrehi 3018 7 retrieved retrieve VBD cord-335975-m6lkrehi 3018 8 monocytes monocyte NNS cord-335975-m6lkrehi 3018 9 / / SYM cord-335975-m6lkrehi 3018 10 macrophages macrophage NNS cord-335975-m6lkrehi 3018 11 predominance predominance NN cord-335975-m6lkrehi 3018 12 with with IN cord-335975-m6lkrehi 3018 13 two two CD cord-335975-m6lkrehi 3018 14 different different JJ cord-335975-m6lkrehi 3018 15 subsets subset NNS cord-335975-m6lkrehi 3018 16 based base VBN cord-335975-m6lkrehi 3018 17 on on IN cord-335975-m6lkrehi 3018 18 F4/80 f4/80 NN cord-335975-m6lkrehi 3018 19 expression expression NN cord-335975-m6lkrehi 3018 20 ( ( -LRB- cord-335975-m6lkrehi 3018 21 F4/80High F4/80High NNP cord-335975-m6lkrehi 3018 22 and and CC cord-335975-m6lkrehi 3018 23 F4/80Low F4/80Low NNP cord-335975-m6lkrehi 3018 24 ) ) -RRB- cord-335975-m6lkrehi 3018 25 . . . cord-335975-m6lkrehi 3019 1 Late late JJ cord-335975-m6lkrehi 3019 2 - - HYPH cord-335975-m6lkrehi 3019 3 onset onset NN cord-335975-m6lkrehi 3019 4 ( ( -LRB- cord-335975-m6lkrehi 3019 5 day day NN cord-335975-m6lkrehi 3019 6 7 7 CD cord-335975-m6lkrehi 3019 7 ) ) -RRB- cord-335975-m6lkrehi 3019 8 tumors tumor NNS cord-335975-m6lkrehi 3019 9 from from IN cord-335975-m6lkrehi 3019 10 CLP CLP NNP cord-335975-m6lkrehi 3019 11 - - HYPH cord-335975-m6lkrehi 3019 12 operated operate VBN cord-335975-m6lkrehi 3019 13 mice mouse NNS cord-335975-m6lkrehi 3019 14 displayed display VBD cord-335975-m6lkrehi 3019 15 increased increase VBN cord-335975-m6lkrehi 3019 16 proportions proportion NNS cord-335975-m6lkrehi 3019 17 of of IN cord-335975-m6lkrehi 3019 18 F4/80High f4/80high NN cord-335975-m6lkrehi 3019 19 . . . cord-335975-m6lkrehi 3020 1 As as IN cord-335975-m6lkrehi 3020 2 compared compare VBN cord-335975-m6lkrehi 3020 3 to to IN cord-335975-m6lkrehi 3020 4 F4/80Low F4/80Low NNP cord-335975-m6lkrehi 3020 5 cells cell NNS cord-335975-m6lkrehi 3020 6 , , , cord-335975-m6lkrehi 3020 7 F4/80High f4/80high JJ cord-335975-m6lkrehi 3020 8 cells cell NNS cord-335975-m6lkrehi 3020 9 displayed display VBD cord-335975-m6lkrehi 3020 10 a a DT cord-335975-m6lkrehi 3020 11 more more RBR cord-335975-m6lkrehi 3020 12 immature immature JJ cord-335975-m6lkrehi 3020 13 status status NN cord-335975-m6lkrehi 3020 14 with with IN cord-335975-m6lkrehi 3020 15 a a DT cord-335975-m6lkrehi 3020 16 lower low JJR cord-335975-m6lkrehi 3020 17 expression expression NN cord-335975-m6lkrehi 3020 18 of of IN cord-335975-m6lkrehi 3020 19 CD40 CD40 NNP cord-335975-m6lkrehi 3020 20 , , , cord-335975-m6lkrehi 3020 21 MHCII MHCII NNP cord-335975-m6lkrehi 3020 22 and and CC cord-335975-m6lkrehi 3020 23 PDL1 PDL1 NNP cord-335975-m6lkrehi 3020 24 , , , cord-335975-m6lkrehi 3020 25 and and CC cord-335975-m6lkrehi 3020 26 a a DT cord-335975-m6lkrehi 3020 27 higher high JJR cord-335975-m6lkrehi 3020 28 phagocytic phagocytic JJ cord-335975-m6lkrehi 3020 29 activity activity NN cord-335975-m6lkrehi 3020 30 . . . cord-335975-m6lkrehi 3021 1 Interestingly interestingly RB cord-335975-m6lkrehi 3021 2 , , , cord-335975-m6lkrehi 3021 3 F4/80High f4/80high JJ cord-335975-m6lkrehi 3021 4 cells cell NNS cord-335975-m6lkrehi 3021 5 from from IN cord-335975-m6lkrehi 3021 6 CLP CLP NNP cord-335975-m6lkrehi 3021 7 - - HYPH cord-335975-m6lkrehi 3021 8 operated operate VBN cord-335975-m6lkrehi 3021 9 mice mouse NNS cord-335975-m6lkrehi 3021 10 exhibited exhibit VBD cord-335975-m6lkrehi 3021 11 a a DT cord-335975-m6lkrehi 3021 12 higher high JJR cord-335975-m6lkrehi 3021 13 phagocytic phagocytic JJ cord-335975-m6lkrehi 3021 14 activity activity NN cord-335975-m6lkrehi 3021 15 than than IN cord-335975-m6lkrehi 3021 16 those those DT cord-335975-m6lkrehi 3021 17 from from IN cord-335975-m6lkrehi 3021 18 sham sham NN cord-335975-m6lkrehi 3021 19 - - HYPH cord-335975-m6lkrehi 3021 20 operated operate VBN cord-335975-m6lkrehi 3021 21 mice mouse NNS cord-335975-m6lkrehi 3021 22 . . . cord-335975-m6lkrehi 3022 1 Conclusion conclusion NN cord-335975-m6lkrehi 3022 2 : : : cord-335975-m6lkrehi 3022 3 Polymicrobial polymicrobial JJ cord-335975-m6lkrehi 3022 4 sepsis sepsis NN cord-335975-m6lkrehi 3022 5 drives drive VBZ cord-335975-m6lkrehi 3022 6 a a DT cord-335975-m6lkrehi 3022 7 potent potent JJ cord-335975-m6lkrehi 3022 8 antitumoral antitumoral JJ cord-335975-m6lkrehi 3022 9 activity activity NN cord-335975-m6lkrehi 3022 10 in in IN cord-335975-m6lkrehi 3022 11 cancer cancer NN cord-335975-m6lkrehi 3022 12 mice mouse NNS cord-335975-m6lkrehi 3022 13 , , , cord-335975-m6lkrehi 3022 14 which which WDT cord-335975-m6lkrehi 3022 15 is be VBZ cord-335975-m6lkrehi 3022 16 associated associate VBN cord-335975-m6lkrehi 3022 17 with with IN cord-335975-m6lkrehi 3022 18 changes change NNS cord-335975-m6lkrehi 3022 19 in in IN cord-335975-m6lkrehi 3022 20 the the DT cord-335975-m6lkrehi 3022 21 distribution distribution NN cord-335975-m6lkrehi 3022 22 and and CC cord-335975-m6lkrehi 3022 23 functions function NNS cord-335975-m6lkrehi 3022 24 of of IN cord-335975-m6lkrehi 3022 25 tumor tumor NN cord-335975-m6lkrehi 3022 26 - - HYPH cord-335975-m6lkrehi 3022 27 associated associate VBN cord-335975-m6lkrehi 3022 28 monocytes monocyte VBZ cord-335975-m6lkrehi 3022 29 macrophages macrophages NN cord-335975-m6lkrehi 3022 30 subsets subset NNS cord-335975-m6lkrehi 3022 31 . . . cord-335975-m6lkrehi 3023 1 Our -PRON- PRP$ cord-335975-m6lkrehi 3023 2 results result NNS cord-335975-m6lkrehi 3023 3 converge converge VBP cord-335975-m6lkrehi 3023 4 on on IN cord-335975-m6lkrehi 3023 5 a a DT cord-335975-m6lkrehi 3023 6 critical critical JJ cord-335975-m6lkrehi 3023 7 role role NN cord-335975-m6lkrehi 3023 8 of of IN cord-335975-m6lkrehi 3023 9 Tlr4 Tlr4 NNP cord-335975-m6lkrehi 3023 10 signaling signaling NN cord-335975-m6lkrehi 3023 11 , , , cord-335975-m6lkrehi 3023 12 that that DT cord-335975-m6lkrehi 3023 13 should should MD cord-335975-m6lkrehi 3023 14 be be VB cord-335975-m6lkrehi 3023 15 further further RB cord-335975-m6lkrehi 3023 16 investigated investigate VBN cord-335975-m6lkrehi 3023 17 . . . cord-335975-m6lkrehi 3024 1 Conclusion conclusion NN cord-335975-m6lkrehi 3024 2 : : : cord-335975-m6lkrehi 3025 1 Post post JJ cord-335975-m6lkrehi 3025 2 - - JJ cord-335975-m6lkrehi 3025 3 agressive agressive JJ cord-335975-m6lkrehi 3025 4 immunosuppression immunosuppression NN cord-335975-m6lkrehi 3025 5 in in IN cord-335975-m6lkrehi 3025 6 ICU ICU NNP cord-335975-m6lkrehi 3025 7 is be VBZ cord-335975-m6lkrehi 3025 8 not not RB cord-335975-m6lkrehi 3025 9 specific specific JJ cord-335975-m6lkrehi 3025 10 to to IN cord-335975-m6lkrehi 3025 11 sepsis sepsis NN cord-335975-m6lkrehi 3025 12 . . . cord-335975-m6lkrehi 3026 1 In in IN cord-335975-m6lkrehi 3026 2 septic septic JJ cord-335975-m6lkrehi 3026 3 shock shock NN cord-335975-m6lkrehi 3026 4 , , , cord-335975-m6lkrehi 3026 5 the the DT cord-335975-m6lkrehi 3026 6 low low JJ cord-335975-m6lkrehi 3026 7 counts count NNS cord-335975-m6lkrehi 3026 8 in in IN cord-335975-m6lkrehi 3026 9 circulating circulate VBG cord-335975-m6lkrehi 3027 1 ILC3 ILC3 NNP cord-335975-m6lkrehi 3027 2 s s PRP cord-335975-m6lkrehi 3027 3 could could MD cord-335975-m6lkrehi 3027 4 be be VB cord-335975-m6lkrehi 3027 5 explained explain VBN cord-335975-m6lkrehi 3027 6 by by IN cord-335975-m6lkrehi 3027 7 ILC ILC NNP cord-335975-m6lkrehi 3027 8 plasticity plasticity NN cord-335975-m6lkrehi 3027 9 ( ( -LRB- cord-335975-m6lkrehi 3027 10 conversion conversion NN cord-335975-m6lkrehi 3027 11 of of IN cord-335975-m6lkrehi 3027 12 these these DT cord-335975-m6lkrehi 3027 13 cells cell NNS cord-335975-m6lkrehi 3027 14 into into IN cord-335975-m6lkrehi 3027 15 ILC1 ILC1 NNP cord-335975-m6lkrehi 3027 16 s s NNP cord-335975-m6lkrehi 3027 17 ) ) -RRB- cord-335975-m6lkrehi 3027 18 , , , cord-335975-m6lkrehi 3027 19 by by IN cord-335975-m6lkrehi 3027 20 migration migration NN cord-335975-m6lkrehi 3027 21 from from IN cord-335975-m6lkrehi 3027 22 the the DT cord-335975-m6lkrehi 3027 23 blood blood NN cord-335975-m6lkrehi 3027 24 or or CC cord-335975-m6lkrehi 3027 25 by by IN cord-335975-m6lkrehi 3027 26 an an DT cord-335975-m6lkrehi 3027 27 exacerbated exacerbate VBN cord-335975-m6lkrehi 3027 28 apoptosis apoptosis NN cord-335975-m6lkrehi 3027 29 . . . cord-335975-m6lkrehi 3028 1 ILC2 ILC2 NNP cord-335975-m6lkrehi 3028 2 s s POS cord-335975-m6lkrehi 3028 3 expansion expansion NN cord-335975-m6lkrehi 3028 4 , , , cord-335975-m6lkrehi 3028 5 associated associate VBN cord-335975-m6lkrehi 3028 6 with with IN cord-335975-m6lkrehi 3028 7 a a DT cord-335975-m6lkrehi 3028 8 higher high JJR cord-335975-m6lkrehi 3028 9 risk risk NN cord-335975-m6lkrehi 3028 10 of of IN cord-335975-m6lkrehi 3028 11 secondary secondary JJ cord-335975-m6lkrehi 3028 12 infection infection NN cord-335975-m6lkrehi 3028 13 , , , cord-335975-m6lkrehi 3028 14 could could MD cord-335975-m6lkrehi 3028 15 be be VB cord-335975-m6lkrehi 3028 16 promoted promote VBN cord-335975-m6lkrehi 3028 17 by by IN cord-335975-m6lkrehi 3028 18 IL-33 IL-33 NNP cord-335975-m6lkrehi 3028 19 , , , cord-335975-m6lkrehi 3028 20 released release VBN cord-335975-m6lkrehi 3028 21 by by IN cord-335975-m6lkrehi 3028 22 tissue tissue NN cord-335975-m6lkrehi 3028 23 injuries injury NNS cord-335975-m6lkrehi 3028 24 . . . cord-335975-m6lkrehi 3029 1 ILC2 ILC2 NNP cord-335975-m6lkrehi 3029 2 s s POS cord-335975-m6lkrehi 3029 3 could could MD cord-335975-m6lkrehi 3029 4 activate activate VB cord-335975-m6lkrehi 3029 5 regulatory regulatory JJ cord-335975-m6lkrehi 3029 6 T t NN cord-335975-m6lkrehi 3029 7 cells cell NNS cord-335975-m6lkrehi 3029 8 via via IN cord-335975-m6lkrehi 3029 9 IL-10 IL-10 NNP cord-335975-m6lkrehi 3029 10 . . . cord-335975-m6lkrehi 3030 1 These these DT cord-335975-m6lkrehi 3030 2 preliminary preliminary JJ cord-335975-m6lkrehi 3030 3 results result NNS cord-335975-m6lkrehi 3030 4 must must MD cord-335975-m6lkrehi 3030 5 be be VB cord-335975-m6lkrehi 3030 6 confirmed confirm VBN cord-335975-m6lkrehi 3030 7 on on IN cord-335975-m6lkrehi 3030 8 a a DT cord-335975-m6lkrehi 3030 9 larger large JJR cord-335975-m6lkrehi 3030 10 cohort cohort NN cord-335975-m6lkrehi 3030 11 . . . cord-335975-m6lkrehi 3031 1 They -PRON- PRP cord-335975-m6lkrehi 3031 2 play play VBP cord-335975-m6lkrehi 3031 3 a a DT cord-335975-m6lkrehi 3031 4 suppressive suppressive JJ cord-335975-m6lkrehi 3031 5 role role NN cord-335975-m6lkrehi 3031 6 in in IN cord-335975-m6lkrehi 3031 7 the the DT cord-335975-m6lkrehi 3031 8 immune immune JJ cord-335975-m6lkrehi 3031 9 system system NN cord-335975-m6lkrehi 3031 10 by by IN cord-335975-m6lkrehi 3031 11 the the DT cord-335975-m6lkrehi 3031 12 secretion secretion NN cord-335975-m6lkrehi 3031 13 of of IN cord-335975-m6lkrehi 3031 14 negative negative JJ cord-335975-m6lkrehi 3031 15 regulatory regulatory JJ cord-335975-m6lkrehi 3031 16 cytokines cytokine NNS cord-335975-m6lkrehi 3031 17 such such JJ cord-335975-m6lkrehi 3031 18 as as IN cord-335975-m6lkrehi 3031 19 interleukin-10 interleukin-10 NN cord-335975-m6lkrehi 3031 20 or or CC cord-335975-m6lkrehi 3031 21 by by IN cord-335975-m6lkrehi 3031 22 immune immune JJ cord-335975-m6lkrehi 3031 23 cell cell NN cord-335975-m6lkrehi 3031 24 contact contact NN cord-335975-m6lkrehi 3031 25 inhibition inhibition NN cord-335975-m6lkrehi 3031 26 . . . cord-335975-m6lkrehi 3032 1 The the DT cord-335975-m6lkrehi 3032 2 objective objective NN cord-335975-m6lkrehi 3032 3 of of IN cord-335975-m6lkrehi 3032 4 this this DT cord-335975-m6lkrehi 3032 5 pilot pilot NN cord-335975-m6lkrehi 3032 6 study study NN cord-335975-m6lkrehi 3032 7 was be VBD cord-335975-m6lkrehi 3032 8 to to TO cord-335975-m6lkrehi 3032 9 develop develop VB cord-335975-m6lkrehi 3032 10 and and CC cord-335975-m6lkrehi 3032 11 test test VB cord-335975-m6lkrehi 3032 12 a a DT cord-335975-m6lkrehi 3032 13 protocol protocol NN cord-335975-m6lkrehi 3032 14 to to TO cord-335975-m6lkrehi 3032 15 determine determine VB cord-335975-m6lkrehi 3032 16 the the DT cord-335975-m6lkrehi 3032 17 Breg Breg NNP cord-335975-m6lkrehi 3032 18 level level NN cord-335975-m6lkrehi 3032 19 in in IN cord-335975-m6lkrehi 3032 20 septic septic JJ cord-335975-m6lkrehi 3032 21 patients patient NNS cord-335975-m6lkrehi 3032 22 . . . cord-335975-m6lkrehi 3033 1 The the DT cord-335975-m6lkrehi 3033 2 level level NN cord-335975-m6lkrehi 3033 3 of of IN cord-335975-m6lkrehi 3033 4 Breg Breg NNP cord-335975-m6lkrehi 3033 5 were be VBD cord-335975-m6lkrehi 3033 6 measured measure VBN cord-335975-m6lkrehi 3033 7 on on IN cord-335975-m6lkrehi 3033 8 whole whole JJ cord-335975-m6lkrehi 3033 9 blood blood NN cord-335975-m6lkrehi 3033 10 sample sample NN cord-335975-m6lkrehi 3033 11 by by IN cord-335975-m6lkrehi 3033 12 flow flow NN cord-335975-m6lkrehi 3033 13 cytometry cytometry NN cord-335975-m6lkrehi 3033 14 the the DT cord-335975-m6lkrehi 3033 15 first first JJ cord-335975-m6lkrehi 3033 16 day day NN cord-335975-m6lkrehi 3033 17 of of IN cord-335975-m6lkrehi 3033 18 hospitalisation hospitalisation NN cord-335975-m6lkrehi 3033 19 in in IN cord-335975-m6lkrehi 3033 20 septic septic JJ cord-335975-m6lkrehi 3033 21 patients patient NNS cord-335975-m6lkrehi 3033 22 . . . cord-335975-m6lkrehi 3034 1 B b NN cord-335975-m6lkrehi 3034 2 cells cell NNS cord-335975-m6lkrehi 3034 3 were be VBD cord-335975-m6lkrehi 3034 4 identified identify VBN cord-335975-m6lkrehi 3034 5 on on IN cord-335975-m6lkrehi 3034 6 the the DT cord-335975-m6lkrehi 3034 7 single single JJ cord-335975-m6lkrehi 3034 8 - - HYPH cord-335975-m6lkrehi 3034 9 parameter parameter NN cord-335975-m6lkrehi 3034 10 expression expression NN cord-335975-m6lkrehi 3034 11 CD19 CD19 NNP cord-335975-m6lkrehi 3034 12 combined combine VBD cord-335975-m6lkrehi 3034 13 with with IN cord-335975-m6lkrehi 3034 14 scatter scatter NN cord-335975-m6lkrehi 3034 15 . . . cord-335975-m6lkrehi 3035 1 The the DT cord-335975-m6lkrehi 3035 2 Breg Breg NNPS cord-335975-m6lkrehi 3035 3 were be VBD cord-335975-m6lkrehi 3035 4 identified identify VBN cord-335975-m6lkrehi 3035 5 as as IN cord-335975-m6lkrehi 3035 6 subpopulation subpopulation NN cord-335975-m6lkrehi 3035 7 expressing express VBG cord-335975-m6lkrehi 3035 8 CD24 CD24 NNP cord-335975-m6lkrehi 3035 9 / / SYM cord-335975-m6lkrehi 3035 10 hiCD38hi hicd38hi ADD cord-335975-m6lkrehi 3035 11 or or CC cord-335975-m6lkrehi 3035 12 CD24 CD24 NNP cord-335975-m6lkrehi 3035 13 / / SYM cord-335975-m6lkrehi 3035 14 hiCD27 hicd27 CD cord-335975-m6lkrehi 3036 1 + + CC cord-335975-m6lkrehi 3036 2 ( ( -LRB- cord-335975-m6lkrehi 3036 3 see see VB cord-335975-m6lkrehi 3036 4 Fig Fig NNP cord-335975-m6lkrehi 3036 5 . . NNP cord-335975-m6lkrehi 3036 6 1 1 CD cord-335975-m6lkrehi 3036 7 ) ) -RRB- cord-335975-m6lkrehi 3036 8 . . . cord-335975-m6lkrehi 3037 1 The the DT cord-335975-m6lkrehi 3037 2 results result NNS cord-335975-m6lkrehi 3037 3 were be VBD cord-335975-m6lkrehi 3037 4 expressed express VBN cord-335975-m6lkrehi 3037 5 as as IN cord-335975-m6lkrehi 3037 6 percentage percentage NN cord-335975-m6lkrehi 3037 7 of of IN cord-335975-m6lkrehi 3037 8 the the DT cord-335975-m6lkrehi 3037 9 parental parental JJ cord-335975-m6lkrehi 3037 10 lineage lineage NN cord-335975-m6lkrehi 3037 11 gate gate NN cord-335975-m6lkrehi 3037 12 and and CC cord-335975-m6lkrehi 3037 13 absolute absolute JJ cord-335975-m6lkrehi 3037 14 value value NN cord-335975-m6lkrehi 3037 15 per per IN cord-335975-m6lkrehi 3037 16 microliter microliter NN cord-335975-m6lkrehi 3037 17 . . . cord-335975-m6lkrehi 3038 1 This this DT cord-335975-m6lkrehi 3038 2 protocol protocol NN cord-335975-m6lkrehi 3038 3 has have VBZ cord-335975-m6lkrehi 3038 4 been be VBN cord-335975-m6lkrehi 3038 5 optimised optimise VBN cord-335975-m6lkrehi 3038 6 in in IN cord-335975-m6lkrehi 3038 7 order order NN cord-335975-m6lkrehi 3038 8 to to TO cord-335975-m6lkrehi 3038 9 be be VB cord-335975-m6lkrehi 3038 10 able able JJ cord-335975-m6lkrehi 3038 11 to to TO cord-335975-m6lkrehi 3038 12 transfer transfer VB cord-335975-m6lkrehi 3038 13 technic technic NN cord-335975-m6lkrehi 3038 14 into into IN cord-335975-m6lkrehi 3038 15 clinical clinical JJ cord-335975-m6lkrehi 3038 16 practice practice NN cord-335975-m6lkrehi 3038 17 . . . cord-335975-m6lkrehi 3039 1 Results result NNS cord-335975-m6lkrehi 3040 1 : : : cord-335975-m6lkrehi 3040 2 We -PRON- PRP cord-335975-m6lkrehi 3040 3 include include VBP cord-335975-m6lkrehi 3040 4 8 8 CD cord-335975-m6lkrehi 3040 5 patients patient NNS cord-335975-m6lkrehi 3040 6 hospitalized hospitalize VBN cord-335975-m6lkrehi 3040 7 in in IN cord-335975-m6lkrehi 3040 8 intensive intensive JJ cord-335975-m6lkrehi 3040 9 care care NN cord-335975-m6lkrehi 3040 10 unit unit NN cord-335975-m6lkrehi 3040 11 with with IN cord-335975-m6lkrehi 3040 12 severe severe JJ cord-335975-m6lkrehi 3040 13 sepsis sepsis NN cord-335975-m6lkrehi 3040 14 or or CC cord-335975-m6lkrehi 3040 15 septic septic JJ cord-335975-m6lkrehi 3040 16 shock shock NN cord-335975-m6lkrehi 3040 17 . . . cord-335975-m6lkrehi 3041 1 The the DT cord-335975-m6lkrehi 3041 2 percentage percentage NN cord-335975-m6lkrehi 3041 3 of of IN cord-335975-m6lkrehi 3041 4 CD19 CD19 NNP cord-335975-m6lkrehi 3041 5 + + CC cord-335975-m6lkrehi 3041 6 CD24hiC cd24hic NN cord-335975-m6lkrehi 3041 7 - - HYPH cord-335975-m6lkrehi 3041 8 D38hi D38hi NNP cord-335975-m6lkrehi 3041 9 was be VBD cord-335975-m6lkrehi 3041 10 6.6 6.6 CD cord-335975-m6lkrehi 3041 11 ± ± CD cord-335975-m6lkrehi 3041 12 5.2 5.2 CD cord-335975-m6lkrehi 3041 13 % % NN cord-335975-m6lkrehi 3041 14 with with IN cord-335975-m6lkrehi 3041 15 a a DT cord-335975-m6lkrehi 3041 16 mean mean NN cord-335975-m6lkrehi 3041 17 of of IN cord-335975-m6lkrehi 3041 18 4.6 4.6 CD cord-335975-m6lkrehi 3041 19 ± ± CD cord-335975-m6lkrehi 3041 20 2.3 2.3 CD cord-335975-m6lkrehi 3041 21 cells cell NNS cord-335975-m6lkrehi 3041 22 microliter microliter JJ cord-335975-m6lkrehi 3041 23 . . . cord-335975-m6lkrehi 3042 1 The the DT cord-335975-m6lkrehi 3042 2 percentage percentage NN cord-335975-m6lkrehi 3042 3 of of IN cord-335975-m6lkrehi 3042 4 CD19 CD19 NNP cord-335975-m6lkrehi 3042 5 + + CC cord-335975-m6lkrehi 3042 6 CD24hiCD27 cd24hicd27 NN cord-335975-m6lkrehi 3042 7 + + CC cord-335975-m6lkrehi 3042 8 was be VBD cord-335975-m6lkrehi 3042 9 9.1 9.1 CD cord-335975-m6lkrehi 3042 10 ± ± CD cord-335975-m6lkrehi 3042 11 4.7 4.7 CD cord-335975-m6lkrehi 3042 12 % % NN cord-335975-m6lkrehi 3042 13 with with IN cord-335975-m6lkrehi 3042 14 a a DT cord-335975-m6lkrehi 3042 15 mean mean NN cord-335975-m6lkrehi 3042 16 of of IN cord-335975-m6lkrehi 3042 17 8.8 8.8 CD cord-335975-m6lkrehi 3042 18 ± ± CD cord-335975-m6lkrehi 3042 19 6.4 6.4 CD cord-335975-m6lkrehi 3042 20 cells cell NNS cord-335975-m6lkrehi 3042 21 microliter microliter JJ cord-335975-m6lkrehi 3042 22 . . . cord-335975-m6lkrehi 3043 1 We -PRON- PRP cord-335975-m6lkrehi 3043 2 are be VBP cord-335975-m6lkrehi 3043 3 able able JJ cord-335975-m6lkrehi 3043 4 to to TO cord-335975-m6lkrehi 3043 5 measure measure VB cord-335975-m6lkrehi 3043 6 and and CC cord-335975-m6lkrehi 3043 7 follow follow VB cord-335975-m6lkrehi 3043 8 the the DT cord-335975-m6lkrehi 3043 9 evolution evolution NN cord-335975-m6lkrehi 3043 10 of of IN cord-335975-m6lkrehi 3043 11 Breg Breg NNP cord-335975-m6lkrehi 3043 12 during during IN cord-335975-m6lkrehi 3043 13 severe severe JJ cord-335975-m6lkrehi 3043 14 sepsis sepsis NN cord-335975-m6lkrehi 3043 15 or or CC cord-335975-m6lkrehi 3043 16 septic septic JJ cord-335975-m6lkrehi 3043 17 shock shock NN cord-335975-m6lkrehi 3043 18 . . . cord-335975-m6lkrehi 3044 1 Because because IN cord-335975-m6lkrehi 3044 2 Breg Breg NNP cord-335975-m6lkrehi 3044 3 could could MD cord-335975-m6lkrehi 3044 4 inhibit inhibit VB cord-335975-m6lkrehi 3044 5 body body NN cord-335975-m6lkrehi 3044 6 immune immune JJ cord-335975-m6lkrehi 3044 7 function function NN cord-335975-m6lkrehi 3044 8 , , , cord-335975-m6lkrehi 3044 9 we -PRON- PRP cord-335975-m6lkrehi 3044 10 wish wish VBP cord-335975-m6lkrehi 3044 11 to to TO cord-335975-m6lkrehi 3044 12 conduct conduct VB cord-335975-m6lkrehi 3044 13 a a DT cord-335975-m6lkrehi 3044 14 prospective prospective JJ cord-335975-m6lkrehi 3044 15 study study NN cord-335975-m6lkrehi 3044 16 to to TO cord-335975-m6lkrehi 3044 17 evaluate evaluate VB cord-335975-m6lkrehi 3044 18 the the DT cord-335975-m6lkrehi 3044 19 correlation correlation NN cord-335975-m6lkrehi 3044 20 between between IN cord-335975-m6lkrehi 3044 21 Breg Breg NNP cord-335975-m6lkrehi 3044 22 level level NN cord-335975-m6lkrehi 3044 23 and and CC cord-335975-m6lkrehi 3044 24 the the DT cord-335975-m6lkrehi 3044 25 prognosis prognosis NN cord-335975-m6lkrehi 3044 26 of of IN cord-335975-m6lkrehi 3044 27 patients patient NNS cord-335975-m6lkrehi 3044 28 with with IN cord-335975-m6lkrehi 3044 29 sepsis sepsis NN cord-335975-m6lkrehi 3044 30 . . . cord-335975-m6lkrehi 3045 1 The the DT cord-335975-m6lkrehi 3045 2 neutrophil neutrophil NN cord-335975-m6lkrehi 3045 3 / / SYM cord-335975-m6lkrehi 3045 4 lymphocyte lymphocyte NN cord-335975-m6lkrehi 3045 5 ratio ratio NN cord-335975-m6lkrehi 3045 6 ( ( -LRB- cord-335975-m6lkrehi 3045 7 NLR NLR NNP cord-335975-m6lkrehi 3045 8 ) ) -RRB- cord-335975-m6lkrehi 3045 9 reflects reflect VBZ cord-335975-m6lkrehi 3045 10 an an DT cord-335975-m6lkrehi 3045 11 inflammatory inflammatory JJ cord-335975-m6lkrehi 3045 12 state state NN cord-335975-m6lkrehi 3045 13 . . . cord-335975-m6lkrehi 3046 1 The the DT cord-335975-m6lkrehi 3046 2 NLR NLR NNP cord-335975-m6lkrehi 3046 3 has have VBZ cord-335975-m6lkrehi 3046 4 recently recently RB cord-335975-m6lkrehi 3046 5 emerged emerge VBN cord-335975-m6lkrehi 3046 6 as as IN cord-335975-m6lkrehi 3046 7 a a DT cord-335975-m6lkrehi 3046 8 prognostic prognostic JJ cord-335975-m6lkrehi 3046 9 marker marker NN cord-335975-m6lkrehi 3046 10 in in IN cord-335975-m6lkrehi 3046 11 colorectal colorectal JJ cord-335975-m6lkrehi 3046 12 cancer cancer NN cord-335975-m6lkrehi 3046 13 patients patient NNS cord-335975-m6lkrehi 3046 14 , , , cord-335975-m6lkrehi 3046 15 acute acute JJ cord-335975-m6lkrehi 3046 16 coronary coronary JJ cord-335975-m6lkrehi 3046 17 syndrome syndrome NN cord-335975-m6lkrehi 3046 18 and and CC cord-335975-m6lkrehi 3046 19 pulmonary pulmonary JJ cord-335975-m6lkrehi 3046 20 embolism embolism NN cord-335975-m6lkrehi 3047 1 ( ( -LRB- cord-335975-m6lkrehi 3047 2 Kayrak Kayrak NNP cord-335975-m6lkrehi 3047 3 M M NNP cord-335975-m6lkrehi 3047 4 , , , cord-335975-m6lkrehi 3047 5 Heart Heart NNP cord-335975-m6lkrehi 3047 6 Lung Lung NNP cord-335975-m6lkrehi 3047 7 Circ Circ NNP cord-335975-m6lkrehi 3047 8 2014 2014 CD cord-335975-m6lkrehi 3047 9 ) ) -RRB- cord-335975-m6lkrehi 3047 10 . . . cord-335975-m6lkrehi 3048 1 The the DT cord-335975-m6lkrehi 3048 2 aim aim NN cord-335975-m6lkrehi 3048 3 of of IN cord-335975-m6lkrehi 3048 4 this this DT cord-335975-m6lkrehi 3048 5 study study NN cord-335975-m6lkrehi 3048 6 was be VBD cord-335975-m6lkrehi 3048 7 to to TO cord-335975-m6lkrehi 3048 8 assess assess VB cord-335975-m6lkrehi 3048 9 the the DT cord-335975-m6lkrehi 3048 10 prognostic prognostic JJ cord-335975-m6lkrehi 3048 11 value value NN cord-335975-m6lkrehi 3048 12 of of IN cord-335975-m6lkrehi 3048 13 NLR NLR NNP cord-335975-m6lkrehi 3048 14 in in IN cord-335975-m6lkrehi 3048 15 patients patient NNS cord-335975-m6lkrehi 3048 16 with with IN cord-335975-m6lkrehi 3048 17 septic septic JJ cord-335975-m6lkrehi 3048 18 shock shock NN cord-335975-m6lkrehi 3048 19 . . . cord-335975-m6lkrehi 3049 1 We -PRON- PRP cord-335975-m6lkrehi 3049 2 performed perform VBD cord-335975-m6lkrehi 3049 3 a a DT cord-335975-m6lkrehi 3049 4 prospective prospective JJ cord-335975-m6lkrehi 3049 5 observational observational JJ cord-335975-m6lkrehi 3049 6 study study NN cord-335975-m6lkrehi 3049 7 in in IN cord-335975-m6lkrehi 3049 8 septic septic JJ cord-335975-m6lkrehi 3049 9 shock shock NN cord-335975-m6lkrehi 3049 10 ICU ICU NNP cord-335975-m6lkrehi 3049 11 patients patient NNS cord-335975-m6lkrehi 3049 12 within within IN cord-335975-m6lkrehi 3049 13 72 72 CD cord-335975-m6lkrehi 3049 14 h h NN cord-335975-m6lkrehi 3049 15 of of IN cord-335975-m6lkrehi 3049 16 admission admission NN cord-335975-m6lkrehi 3049 17 from from IN cord-335975-m6lkrehi 3049 18 January January NNP cord-335975-m6lkrehi 3049 19 to to IN cord-335975-m6lkrehi 3049 20 July July NNP cord-335975-m6lkrehi 3049 21 2017 2017 CD cord-335975-m6lkrehi 3049 22 in in IN cord-335975-m6lkrehi 3049 23 Charles Charles NNP cord-335975-m6lkrehi 3049 24 Nicolle Nicolle NNP cord-335975-m6lkrehi 3049 25 Hospital Hospital NNP cord-335975-m6lkrehi 3049 26 of of IN cord-335975-m6lkrehi 3049 27 Tunis Tunis NNP cord-335975-m6lkrehi 3049 28 . . . cord-335975-m6lkrehi 3050 1 Exclusion exclusion NN cord-335975-m6lkrehi 3050 2 criteria criterion NNS cord-335975-m6lkrehi 3050 3 were be VBD cord-335975-m6lkrehi 3050 4 age age NN cord-335975-m6lkrehi 3050 5 < < XX cord-335975-m6lkrehi 3050 6 18 18 CD cord-335975-m6lkrehi 3050 7 years year NNS cord-335975-m6lkrehi 3050 8 , , , cord-335975-m6lkrehi 3050 9 pregnancy pregnancy NN cord-335975-m6lkrehi 3050 10 + + CC cord-335975-m6lkrehi 3050 11 oncohematological oncohematological JJ cord-335975-m6lkrehi 3050 12 patients patient NNS cord-335975-m6lkrehi 3050 13 , , , cord-335975-m6lkrehi 3050 14 recent recent JJ cord-335975-m6lkrehi 3050 15 blood blood NN cord-335975-m6lkrehi 3050 16 transfusion transfusion NN cord-335975-m6lkrehi 3050 17 , , , cord-335975-m6lkrehi 3050 18 post post JJ cord-335975-m6lkrehi 3050 19 - - JJ cord-335975-m6lkrehi 3050 20 cardiac cardiac JJ cord-335975-m6lkrehi 3050 21 arrest arrest NN cord-335975-m6lkrehi 3050 22 and and CC cord-335975-m6lkrehi 3050 23 brain brain NN cord-335975-m6lkrehi 3050 24 - - HYPH cord-335975-m6lkrehi 3050 25 death death NN cord-335975-m6lkrehi 3050 26 . . . cord-335975-m6lkrehi 3051 1 NLR NLR NNP cord-335975-m6lkrehi 3051 2 was be VBD cord-335975-m6lkrehi 3051 3 measured measure VBN cord-335975-m6lkrehi 3051 4 soon soon RB cord-335975-m6lkrehi 3051 5 after after IN cord-335975-m6lkrehi 3051 6 admission admission NN cord-335975-m6lkrehi 3051 7 and and CC cord-335975-m6lkrehi 3051 8 24h 24h NNS cord-335975-m6lkrehi 3051 9 , , , cord-335975-m6lkrehi 3051 10 48h 48h NNS cord-335975-m6lkrehi 3051 11 , , , cord-335975-m6lkrehi 3051 12 and and CC cord-335975-m6lkrehi 3051 13 72h 72h NNS cord-335975-m6lkrehi 3051 14 after after RB cord-335975-m6lkrehi 3051 15 . . . cord-335975-m6lkrehi 3052 1 Demographic demographic JJ cord-335975-m6lkrehi 3052 2 , , , cord-335975-m6lkrehi 3052 3 clinical clinical JJ cord-335975-m6lkrehi 3052 4 and and CC cord-335975-m6lkrehi 3052 5 biochemical biochemical JJ cord-335975-m6lkrehi 3052 6 parameters parameter NNS cord-335975-m6lkrehi 3052 7 , , , cord-335975-m6lkrehi 3052 8 severity severity NN cord-335975-m6lkrehi 3052 9 scores score NNS cord-335975-m6lkrehi 3052 10 , , , cord-335975-m6lkrehi 3052 11 life life NN cord-335975-m6lkrehi 3052 12 - - HYPH cord-335975-m6lkrehi 3052 13 support support NN cord-335975-m6lkrehi 3052 14 therapies therapy NNS cord-335975-m6lkrehi 3052 15 ( ( -LRB- cord-335975-m6lkrehi 3052 16 vasopressors vasopressor NNS cord-335975-m6lkrehi 3052 17 , , , cord-335975-m6lkrehi 3052 18 ventilation ventilation NN cord-335975-m6lkrehi 3052 19 ) ) -RRB- cord-335975-m6lkrehi 3052 20 , , , cord-335975-m6lkrehi 3052 21 and and CC cord-335975-m6lkrehi 3052 22 length length NN cord-335975-m6lkrehi 3052 23 of of IN cord-335975-m6lkrehi 3052 24 ICU ICU NNP cord-335975-m6lkrehi 3052 25 stay stay NN cord-335975-m6lkrehi 3052 26 were be VBD cord-335975-m6lkrehi 3052 27 recorded record VBN cord-335975-m6lkrehi 3052 28 . . . cord-335975-m6lkrehi 3053 1 The the DT cord-335975-m6lkrehi 3053 2 primary primary JJ cord-335975-m6lkrehi 3053 3 endpoint endpoint NN cord-335975-m6lkrehi 3053 4 was be VBD cord-335975-m6lkrehi 3053 5 28-day 28-day CD cord-335975-m6lkrehi 3053 6 mortality mortality NN cord-335975-m6lkrehi 3053 7 . . . cord-335975-m6lkrehi 3054 1 Results result NNS cord-335975-m6lkrehi 3054 2 : : : cord-335975-m6lkrehi 3055 1 Sixty sixty CD cord-335975-m6lkrehi 3055 2 - - HYPH cord-335975-m6lkrehi 3055 3 five five CD cord-335975-m6lkrehi 3055 4 patients patient NNS cord-335975-m6lkrehi 3055 5 ( ( -LRB- cord-335975-m6lkrehi 3055 6 50 50 CD cord-335975-m6lkrehi 3055 7 males male NNS cord-335975-m6lkrehi 3055 8 , , , cord-335975-m6lkrehi 3055 9 median median JJ cord-335975-m6lkrehi 3055 10 age age NN cord-335975-m6lkrehi 3055 11 , , , cord-335975-m6lkrehi 3055 12 48.5 48.5 CD cord-335975-m6lkrehi 3055 13 years year NNS cord-335975-m6lkrehi 3055 14 ) ) -RRB- cord-335975-m6lkrehi 3055 15 with with IN cord-335975-m6lkrehi 3055 16 septic septic JJ cord-335975-m6lkrehi 3055 17 shock shock NN cord-335975-m6lkrehi 3055 18 were be VBD cord-335975-m6lkrehi 3055 19 included include VBN cord-335975-m6lkrehi 3055 20 in in IN cord-335975-m6lkrehi 3055 21 the the DT cord-335975-m6lkrehi 3055 22 study study NN cord-335975-m6lkrehi 3055 23 . . . cord-335975-m6lkrehi 3056 1 The the DT cord-335975-m6lkrehi 3056 2 28-day 28-day CD cord-335975-m6lkrehi 3056 3 mortality mortality NN cord-335975-m6lkrehi 3056 4 was be VBD cord-335975-m6lkrehi 3056 5 54 54 CD cord-335975-m6lkrehi 3056 6 % % NN cord-335975-m6lkrehi 3056 7 . . . cord-335975-m6lkrehi 3057 1 The the DT cord-335975-m6lkrehi 3057 2 median median JJ cord-335975-m6lkrehi 3057 3 SOFA sofa NN cord-335975-m6lkrehi 3057 4 score score NN cord-335975-m6lkrehi 3057 5 at at IN cord-335975-m6lkrehi 3057 6 T0 T0 NNP cord-335975-m6lkrehi 3057 7 was be VBD cord-335975-m6lkrehi 3057 8 12 12 CD cord-335975-m6lkrehi 3057 9 points point NNS cord-335975-m6lkrehi 3057 10 and and CC cord-335975-m6lkrehi 3057 11 the the DT cord-335975-m6lkrehi 3057 12 median median NN cord-335975-m6lkrehi 3057 13 IGS2 IGS2 NNP cord-335975-m6lkrehi 3057 14 score score NN cord-335975-m6lkrehi 3057 15 was be VBD cord-335975-m6lkrehi 3057 16 55 55 CD cord-335975-m6lkrehi 3057 17 points point NNS cord-335975-m6lkrehi 3057 18 . . . cord-335975-m6lkrehi 3058 1 The the DT cord-335975-m6lkrehi 3058 2 sources source NNS cord-335975-m6lkrehi 3058 3 of of IN cord-335975-m6lkrehi 3058 4 infection infection NN cord-335975-m6lkrehi 3058 5 were be VBD cord-335975-m6lkrehi 3058 6 as as IN cord-335975-m6lkrehi 3058 7 follows follow VBZ cord-335975-m6lkrehi 3058 8 : : : cord-335975-m6lkrehi 3058 9 the the DT cord-335975-m6lkrehi 3058 10 lungs lung NNS cord-335975-m6lkrehi 3058 11 ( ( -LRB- cord-335975-m6lkrehi 3058 12 n n NN cord-335975-m6lkrehi 3058 13 = = SYM cord-335975-m6lkrehi 3058 14 27 27 CD cord-335975-m6lkrehi 3058 15 ) ) -RRB- cord-335975-m6lkrehi 3058 16 , , , cord-335975-m6lkrehi 3058 17 the the DT cord-335975-m6lkrehi 3058 18 urinary urinary JJ cord-335975-m6lkrehi 3058 19 tract tract NN cord-335975-m6lkrehi 3058 20 ( ( -LRB- cord-335975-m6lkrehi 3058 21 n n NN cord-335975-m6lkrehi 3058 22 = = SYM cord-335975-m6lkrehi 3058 23 14 14 CD cord-335975-m6lkrehi 3058 24 ) ) -RRB- cord-335975-m6lkrehi 3058 25 , , , cord-335975-m6lkrehi 3058 26 the the DT cord-335975-m6lkrehi 3058 27 central central JJ cord-335975-m6lkrehi 3058 28 nervous nervous JJ cord-335975-m6lkrehi 3058 29 system system NN cord-335975-m6lkrehi 3058 30 ( ( -LRB- cord-335975-m6lkrehi 3058 31 n n NN cord-335975-m6lkrehi 3058 32 = = SYM cord-335975-m6lkrehi 3058 33 4 4 CD cord-335975-m6lkrehi 3058 34 ) ) -RRB- cord-335975-m6lkrehi 3058 35 , , , cord-335975-m6lkrehi 3058 36 the the DT cord-335975-m6lkrehi 3058 37 abdomen abdomen NN cord-335975-m6lkrehi 3058 38 ( ( -LRB- cord-335975-m6lkrehi 3058 39 n n NN cord-335975-m6lkrehi 3058 40 = = SYM cord-335975-m6lkrehi 3058 41 8) 8) NN cord-335975-m6lkrehi 3058 42 , , , cord-335975-m6lkrehi 3058 43 skin skin NN cord-335975-m6lkrehi 3058 44 and and CC cord-335975-m6lkrehi 3058 45 soft soft JJ cord-335975-m6lkrehi 3058 46 tissue tissue NN cord-335975-m6lkrehi 3058 47 ( ( -LRB- cord-335975-m6lkrehi 3058 48 n n NN cord-335975-m6lkrehi 3058 49 = = SYM cord-335975-m6lkrehi 3058 50 12 12 CD cord-335975-m6lkrehi 3058 51 ) ) -RRB- cord-335975-m6lkrehi 3058 52 . . . cord-335975-m6lkrehi 3059 1 The the DT cord-335975-m6lkrehi 3059 2 parameters parameter NNS cord-335975-m6lkrehi 3059 3 that that WDT cord-335975-m6lkrehi 3059 4 were be VBD cord-335975-m6lkrehi 3059 5 identified identify VBN cord-335975-m6lkrehi 3059 6 through through IN cord-335975-m6lkrehi 3059 7 univariate univariate JJ cord-335975-m6lkrehi 3059 8 analysis analysis NN cord-335975-m6lkrehi 3059 9 to to TO cord-335975-m6lkrehi 3059 10 be be VB cord-335975-m6lkrehi 3059 11 associated associate VBN cord-335975-m6lkrehi 3059 12 with with IN cord-335975-m6lkrehi 3059 13 28-day 28-day CD cord-335975-m6lkrehi 3059 14 mortality mortality NN cord-335975-m6lkrehi 3059 15 were be VBD cord-335975-m6lkrehi 3059 16 IGS2 IGS2 NNP cord-335975-m6lkrehi 3059 17 score score NN cord-335975-m6lkrehi 3059 18 , , , cord-335975-m6lkrehi 3059 19 lactate lactate NN cord-335975-m6lkrehi 3059 20 level level NN cord-335975-m6lkrehi 3059 21 , , , cord-335975-m6lkrehi 3059 22 the the DT cord-335975-m6lkrehi 3059 23 NLR NLR NNP cord-335975-m6lkrehi 3059 24 elevation elevation NN cord-335975-m6lkrehi 3059 25 at at IN cord-335975-m6lkrehi 3059 26 H24 H24 NNP cord-335975-m6lkrehi 3059 27 , , , cord-335975-m6lkrehi 3059 28 H48 H48 NNP cord-335975-m6lkrehi 3059 29 and and CC cord-335975-m6lkrehi 3059 30 H72 H72 NNP cord-335975-m6lkrehi 3059 31 . . . cord-335975-m6lkrehi 3060 1 Median median JJ cord-335975-m6lkrehi 3060 2 NLR NLR NNP cord-335975-m6lkrehi 3060 3 levels level NNS cord-335975-m6lkrehi 3060 4 were be VBD cord-335975-m6lkrehi 3060 5 significantly significantly RB cord-335975-m6lkrehi 3060 6 higher high JJR cord-335975-m6lkrehi 3060 7 in in IN cord-335975-m6lkrehi 3060 8 non non NNS cord-335975-m6lkrehi 3060 9 - - NNS cord-335975-m6lkrehi 3060 10 survivors survivor NNS cord-335975-m6lkrehi 3060 11 ( ( -LRB- cord-335975-m6lkrehi 3060 12 n n NN cord-335975-m6lkrehi 3060 13 = = SYM cord-335975-m6lkrehi 3060 14 35 35 CD cord-335975-m6lkrehi 3060 15 ) ) -RRB- cord-335975-m6lkrehi 3060 16 than than IN cord-335975-m6lkrehi 3060 17 survivors survivor NNS cord-335975-m6lkrehi 3061 1 ( ( -LRB- cord-335975-m6lkrehi 3061 2 Introduction introduction NN cord-335975-m6lkrehi 3061 3 : : : cord-335975-m6lkrehi 3061 4 The the DT cord-335975-m6lkrehi 3061 5 autonomic autonomic JJ cord-335975-m6lkrehi 3061 6 nervous nervous JJ cord-335975-m6lkrehi 3061 7 system system NN cord-335975-m6lkrehi 3061 8 ( ( -LRB- cord-335975-m6lkrehi 3061 9 ANS ANS NNP cord-335975-m6lkrehi 3061 10 ) ) -RRB- cord-335975-m6lkrehi 3061 11 is be VBZ cord-335975-m6lkrehi 3061 12 highly highly RB cord-335975-m6lkrehi 3061 13 adaptable adaptable JJ cord-335975-m6lkrehi 3061 14 and and CC cord-335975-m6lkrehi 3061 15 allows allow VBZ cord-335975-m6lkrehi 3061 16 the the DT cord-335975-m6lkrehi 3061 17 organism organism NN cord-335975-m6lkrehi 3061 18 to to TO cord-335975-m6lkrehi 3061 19 maintain maintain VB cord-335975-m6lkrehi 3061 20 its -PRON- PRP$ cord-335975-m6lkrehi 3061 21 balance balance NN cord-335975-m6lkrehi 3061 22 when when WRB cord-335975-m6lkrehi 3061 23 experiencing experience VBG cord-335975-m6lkrehi 3061 24 stress stress NN cord-335975-m6lkrehi 3061 25 . . . cord-335975-m6lkrehi 3062 1 Heart heart NN cord-335975-m6lkrehi 3062 2 rate rate NN cord-335975-m6lkrehi 3062 3 variability variability NN cord-335975-m6lkrehi 3062 4 ( ( -LRB- cord-335975-m6lkrehi 3062 5 HRV HRV NNP cord-335975-m6lkrehi 3062 6 ) ) -RRB- cord-335975-m6lkrehi 3062 7 is be VBZ cord-335975-m6lkrehi 3062 8 a a DT cord-335975-m6lkrehi 3062 9 mean mean NN cord-335975-m6lkrehi 3062 10 to to TO cord-335975-m6lkrehi 3062 11 evaluate evaluate VB cord-335975-m6lkrehi 3062 12 cardiac cardiac JJ cord-335975-m6lkrehi 3062 13 effects effect NNS cord-335975-m6lkrehi 3062 14 of of IN cord-335975-m6lkrehi 3062 15 ANS ANS NNP cord-335975-m6lkrehi 3062 16 activity activity NN cord-335975-m6lkrehi 3062 17 and and CC cord-335975-m6lkrehi 3062 18 a a DT cord-335975-m6lkrehi 3062 19 relation relation NN cord-335975-m6lkrehi 3062 20 between between IN cord-335975-m6lkrehi 3062 21 HRV HRV NNP cord-335975-m6lkrehi 3062 22 and and CC cord-335975-m6lkrehi 3062 23 outcome outcome NN cord-335975-m6lkrehi 3062 24 has have VBZ cord-335975-m6lkrehi 3062 25 been be VBN cord-335975-m6lkrehi 3062 26 proposed propose VBN cord-335975-m6lkrehi 3062 27 in in IN cord-335975-m6lkrehi 3062 28 various various JJ cord-335975-m6lkrehi 3062 29 types type NNS cord-335975-m6lkrehi 3062 30 of of IN cord-335975-m6lkrehi 3062 31 patients patient NNS cord-335975-m6lkrehi 3062 32 . . . cord-335975-m6lkrehi 3063 1 We -PRON- PRP cord-335975-m6lkrehi 3063 2 evaluated evaluate VBD cord-335975-m6lkrehi 3063 3 the the DT cord-335975-m6lkrehi 3063 4 feasibility feasibility NN cord-335975-m6lkrehi 3063 5 of of IN cord-335975-m6lkrehi 3063 6 a a DT cord-335975-m6lkrehi 3063 7 automated automate VBN cord-335975-m6lkrehi 3063 8 HRV HRV NNP cord-335975-m6lkrehi 3063 9 monitoring monitoring NN cord-335975-m6lkrehi 3063 10 , , , cord-335975-m6lkrehi 3063 11 based base VBN cord-335975-m6lkrehi 3063 12 on on IN cord-335975-m6lkrehi 3063 13 standard standard JJ cord-335975-m6lkrehi 3063 14 electrocardiography electrocardiography NN cord-335975-m6lkrehi 3063 15 monitoring monitoring NN cord-335975-m6lkrehi 3063 16 , , , cord-335975-m6lkrehi 3063 17 and and CC cord-335975-m6lkrehi 3063 18 investigated investigate VBD cord-335975-m6lkrehi 3063 19 the the DT cord-335975-m6lkrehi 3063 20 different different JJ cord-335975-m6lkrehi 3063 21 parameters parameter NNS cord-335975-m6lkrehi 3063 22 that that WDT cord-335975-m6lkrehi 3063 23 should should MD cord-335975-m6lkrehi 3063 24 be be VB cord-335975-m6lkrehi 3063 25 recorded record VBN cord-335975-m6lkrehi 3063 26 . . . cord-335975-m6lkrehi 3064 1 This this DT cord-335975-m6lkrehi 3064 2 project project NN cord-335975-m6lkrehi 3064 3 is be VBZ cord-335975-m6lkrehi 3064 4 based base VBN cord-335975-m6lkrehi 3064 5 on on IN cord-335975-m6lkrehi 3064 6 a a DT cord-335975-m6lkrehi 3064 7 prospective prospective JJ cord-335975-m6lkrehi 3064 8 physiological physiological JJ cord-335975-m6lkrehi 3064 9 tracing tracing NN cord-335975-m6lkrehi 3064 10 data data NN cord-335975-m6lkrehi 3064 11 - - HYPH cord-335975-m6lkrehi 3064 12 warehousing warehousing NN cord-335975-m6lkrehi 3064 13 program program NN cord-335975-m6lkrehi 3064 14 ( ( -LRB- cord-335975-m6lkrehi 3064 15 Rea Rea NNP cord-335975-m6lkrehi 3064 16 STOC STOC NNP cord-335975-m6lkrehi 3064 17 , , , cord-335975-m6lkrehi 3065 1 clinicaltrials.gov clinicaltrials.gov NNP cord-335975-m6lkrehi 3065 2 # # NN cord-335975-m6lkrehi 3065 3 NCT02893462 NCT02893462 NNP cord-335975-m6lkrehi 3065 4 ) ) -RRB- cord-335975-m6lkrehi 3066 1 that that DT cord-335975-m6lkrehi 3066 2 aims aim VBZ cord-335975-m6lkrehi 3066 3 to to TO cord-335975-m6lkrehi 3066 4 record record VB cord-335975-m6lkrehi 3066 5 more more JJR cord-335975-m6lkrehi 3066 6 than than IN cord-335975-m6lkrehi 3066 7 1500 1500 CD cord-335975-m6lkrehi 3066 8 ICU ICU NNP cord-335975-m6lkrehi 3066 9 patients patient NNS cord-335975-m6lkrehi 3066 10 over over IN cord-335975-m6lkrehi 3066 11 a a DT cord-335975-m6lkrehi 3066 12 3-years 3-years CD cord-335975-m6lkrehi 3066 13 period period NN cord-335975-m6lkrehi 3066 14 . . . cord-335975-m6lkrehi 3067 1 Patients patient NNS cord-335975-m6lkrehi 3067 2 and and CC cord-335975-m6lkrehi 3067 3 methods method NNS cord-335975-m6lkrehi 3067 4 : : : cord-335975-m6lkrehi 3067 5 Physiological physiological JJ cord-335975-m6lkrehi 3067 6 tracings tracing NNS cord-335975-m6lkrehi 3067 7 were be VBD cord-335975-m6lkrehi 3067 8 recorded record VBN cord-335975-m6lkrehi 3067 9 from from IN cord-335975-m6lkrehi 3067 10 the the DT cord-335975-m6lkrehi 3067 11 standard standard JJ cord-335975-m6lkrehi 3067 12 monitoring monitoring NN cord-335975-m6lkrehi 3067 13 system system NN cord-335975-m6lkrehi 3067 14 ( ( -LRB- cord-335975-m6lkrehi 3067 15 Intelliview Intelliview NNP cord-335975-m6lkrehi 3067 16 MP70 MP70 NNP cord-335975-m6lkrehi 3067 17 Philips Philips NNP cord-335975-m6lkrehi 3067 18 ) ) -RRB- cord-335975-m6lkrehi 3067 19 , , , cord-335975-m6lkrehi 3067 20 using use VBG cord-335975-m6lkrehi 3067 21 a a DT cord-335975-m6lkrehi 3067 22 dedicated dedicated JJ cord-335975-m6lkrehi 3067 23 network network NN cord-335975-m6lkrehi 3067 24 and and CC cord-335975-m6lkrehi 3067 25 extraction extraction NN cord-335975-m6lkrehi 3067 26 software software NN cord-335975-m6lkrehi 3067 27 ( ( -LRB- cord-335975-m6lkrehi 3067 28 Synapse Synapse NNP cord-335975-m6lkrehi 3067 29 v1 v1 NNS cord-335975-m6lkrehi 3067 30 , , , cord-335975-m6lkrehi 3067 31 LTSI LTSI NNP cord-335975-m6lkrehi 3067 32 INSERM INSERM NNP cord-335975-m6lkrehi 3067 33 U1099 U1099 NNP cord-335975-m6lkrehi 3067 34 ) ) -RRB- cord-335975-m6lkrehi 3067 35 that that WDT cord-335975-m6lkrehi 3067 36 enables enable VBZ cord-335975-m6lkrehi 3067 37 simultaneous simultaneous JJ cord-335975-m6lkrehi 3067 38 recording recording NN cord-335975-m6lkrehi 3067 39 of of IN cord-335975-m6lkrehi 3067 40 5 5 CD cord-335975-m6lkrehi 3067 41 different different JJ cord-335975-m6lkrehi 3067 42 physiological physiological JJ cord-335975-m6lkrehi 3067 43 curves curve NNS cord-335975-m6lkrehi 3067 44 , , , cord-335975-m6lkrehi 3067 45 at at IN cord-335975-m6lkrehi 3067 46 their -PRON- PRP$ cord-335975-m6lkrehi 3067 47 native native JJ cord-335975-m6lkrehi 3067 48 resolution resolution NN cord-335975-m6lkrehi 3067 49 ( ( -LRB- cord-335975-m6lkrehi 3067 50 500 500 CD cord-335975-m6lkrehi 3067 51 Hz Hz NNP cord-335975-m6lkrehi 3067 52 for for IN cord-335975-m6lkrehi 3067 53 ECG ECG NNP cord-335975-m6lkrehi 3067 54 , , , cord-335975-m6lkrehi 3067 55 125 125 CD cord-335975-m6lkrehi 3067 56 Hz Hz NNP cord-335975-m6lkrehi 3067 57 for for IN cord-335975-m6lkrehi 3067 58 other other JJ cord-335975-m6lkrehi 3067 59 ) ) -RRB- cord-335975-m6lkrehi 3067 60 . . . cord-335975-m6lkrehi 3068 1 Raw raw JJ cord-335975-m6lkrehi 3068 2 data datum NNS cord-335975-m6lkrehi 3068 3 were be VBD cord-335975-m6lkrehi 3068 4 subsequently subsequently RB cord-335975-m6lkrehi 3068 5 stored store VBN cord-335975-m6lkrehi 3068 6 on on IN cord-335975-m6lkrehi 3068 7 a a DT cord-335975-m6lkrehi 3068 8 dedicated dedicated JJ cord-335975-m6lkrehi 3068 9 local local JJ cord-335975-m6lkrehi 3068 10 server server NN cord-335975-m6lkrehi 3068 11 , , , cord-335975-m6lkrehi 3068 12 before before IN cord-335975-m6lkrehi 3068 13 anonymization anonymization NN cord-335975-m6lkrehi 3068 14 and and CC cord-335975-m6lkrehi 3068 15 analysis analysis NN cord-335975-m6lkrehi 3068 16 . . . cord-335975-m6lkrehi 3069 1 All all DT cord-335975-m6lkrehi 3069 2 consecutive consecutive JJ cord-335975-m6lkrehi 3069 3 patients patient NNS cord-335975-m6lkrehi 3069 4 were be VBD cord-335975-m6lkrehi 3069 5 recorded record VBN cord-335975-m6lkrehi 3069 6 for for IN cord-335975-m6lkrehi 3069 7 a a DT cord-335975-m6lkrehi 3069 8 2-hours 2-hours CD cord-335975-m6lkrehi 3069 9 period period NN cord-335975-m6lkrehi 3069 10 during during IN cord-335975-m6lkrehi 3069 11 the the DT cord-335975-m6lkrehi 3069 12 24-hours 24-hours CD cord-335975-m6lkrehi 3069 13 following follow VBG cord-335975-m6lkrehi 3069 14 ICU ICU NNP cord-335975-m6lkrehi 3069 15 admission admission NN cord-335975-m6lkrehi 3069 16 . . . cord-335975-m6lkrehi 3070 1 All all DT cord-335975-m6lkrehi 3070 2 measurements measurement NNS cord-335975-m6lkrehi 3070 3 were be VBD cord-335975-m6lkrehi 3070 4 recorded record VBN cord-335975-m6lkrehi 3070 5 with with IN cord-335975-m6lkrehi 3070 6 the the DT cord-335975-m6lkrehi 3070 7 patient patient NN cord-335975-m6lkrehi 3070 8 laying lay VBG cord-335975-m6lkrehi 3070 9 supine supine JJ cord-335975-m6lkrehi 3070 10 , , , cord-335975-m6lkrehi 3070 11 with with IN cord-335975-m6lkrehi 3070 12 a a DT cord-335975-m6lkrehi 3070 13 30 30 CD cord-335975-m6lkrehi 3070 14 ° ° NN cord-335975-m6lkrehi 3070 15 bed bed NN cord-335975-m6lkrehi 3070 16 head head NN cord-335975-m6lkrehi 3070 17 angulation angulation NN cord-335975-m6lkrehi 3070 18 . . . cord-335975-m6lkrehi 3071 1 Physiological physiological JJ cord-335975-m6lkrehi 3071 2 recordings recording NNS cord-335975-m6lkrehi 3071 3 were be VBD cord-335975-m6lkrehi 3071 4 associated associate VBN cord-335975-m6lkrehi 3071 5 with with IN cord-335975-m6lkrehi 3071 6 metadata metadata NN cord-335975-m6lkrehi 3071 7 collection collection NN cord-335975-m6lkrehi 3071 8 by by IN cord-335975-m6lkrehi 3071 9 a a DT cord-335975-m6lkrehi 3071 10 dedicated dedicated JJ cord-335975-m6lkrehi 3071 11 research research NN cord-335975-m6lkrehi 3071 12 assistant assistant NN cord-335975-m6lkrehi 3071 13 . . . cord-335975-m6lkrehi 3072 1 HRV HRV NNP cord-335975-m6lkrehi 3072 2 parameters parameter NNS cord-335975-m6lkrehi 3072 3 were be VBD cord-335975-m6lkrehi 3072 4 derived derive VBN cord-335975-m6lkrehi 3072 5 from from IN cord-335975-m6lkrehi 3072 6 electrocardiography electrocardiography NN cord-335975-m6lkrehi 3072 7 monitoring monitoring NN cord-335975-m6lkrehi 3072 8 using use VBG cord-335975-m6lkrehi 3072 9 Kubios Kubios NNP cord-335975-m6lkrehi 3072 10 HRV HRV NNP cord-335975-m6lkrehi 3072 11 premium premium NN cord-335975-m6lkrehi 3072 12 ( ( -LRB- cord-335975-m6lkrehi 3072 13 Introduction introduction NN cord-335975-m6lkrehi 3072 14 : : : cord-335975-m6lkrehi 3072 15 Acute Acute NNP cord-335975-m6lkrehi 3072 16 Cor Cor NNP cord-335975-m6lkrehi 3072 17 Pulmonale Pulmonale NNP cord-335975-m6lkrehi 3072 18 ( ( -LRB- cord-335975-m6lkrehi 3072 19 ACP ACP NNP cord-335975-m6lkrehi 3072 20 ) ) -RRB- cord-335975-m6lkrehi 3072 21 is be VBZ cord-335975-m6lkrehi 3072 22 a a DT cord-335975-m6lkrehi 3072 23 frequent frequent JJ cord-335975-m6lkrehi 3072 24 complication complication NN cord-335975-m6lkrehi 3072 25 of of IN cord-335975-m6lkrehi 3072 26 acute acute JJ cord-335975-m6lkrehi 3072 27 respiratory respiratory JJ cord-335975-m6lkrehi 3072 28 distress distress NN cord-335975-m6lkrehi 3072 29 syndrome syndrome NN cord-335975-m6lkrehi 3072 30 ( ( -LRB- cord-335975-m6lkrehi 3072 31 ARDS ARDS NNP cord-335975-m6lkrehi 3072 32 ) ) -RRB- cord-335975-m6lkrehi 3072 33 . . . cord-335975-m6lkrehi 3073 1 It -PRON- PRP cord-335975-m6lkrehi 3073 2 occurs occur VBZ cord-335975-m6lkrehi 3073 3 in in IN cord-335975-m6lkrehi 3073 4 22 22 CD cord-335975-m6lkrehi 3073 5 % % NN cord-335975-m6lkrehi 3073 6 of of IN cord-335975-m6lkrehi 3073 7 cases case NNS cord-335975-m6lkrehi 3073 8 and and CC cord-335975-m6lkrehi 3073 9 might may MD cord-335975-m6lkrehi 3073 10 be be VB cord-335975-m6lkrehi 3073 11 associated associate VBN cord-335975-m6lkrehi 3073 12 with with IN cord-335975-m6lkrehi 3073 13 an an DT cord-335975-m6lkrehi 3073 14 increased increase VBN cord-335975-m6lkrehi 3073 15 mortality mortality NN cord-335975-m6lkrehi 3073 16 rate rate NN cord-335975-m6lkrehi 3073 17 . . . cord-335975-m6lkrehi 3074 1 It -PRON- PRP cord-335975-m6lkrehi 3074 2 is be VBZ cord-335975-m6lkrehi 3074 3 defined define VBN cord-335975-m6lkrehi 3074 4 by by IN cord-335975-m6lkrehi 3074 5 a a DT cord-335975-m6lkrehi 3074 6 ratio ratio NN cord-335975-m6lkrehi 3074 7 of of IN cord-335975-m6lkrehi 3074 8 telediastolic telediastolic JJ cord-335975-m6lkrehi 3074 9 surfaces surface NNS cord-335975-m6lkrehi 3074 10 of of IN cord-335975-m6lkrehi 3074 11 right right JJ cord-335975-m6lkrehi 3074 12 ventricular ventricular NN cord-335975-m6lkrehi 3074 13 ( ( -LRB- cord-335975-m6lkrehi 3074 14 RV rv NN cord-335975-m6lkrehi 3074 15 ) ) -RRB- cord-335975-m6lkrehi 3074 16 on on IN cord-335975-m6lkrehi 3074 17 left leave VBN cord-335975-m6lkrehi 3074 18 ventricular ventricular JJ cord-335975-m6lkrehi 3074 19 greater great JJR cord-335975-m6lkrehi 3074 20 than than IN cord-335975-m6lkrehi 3074 21 0.6 0.6 CD cord-335975-m6lkrehi 3074 22 and and CC cord-335975-m6lkrehi 3074 23 a a DT cord-335975-m6lkrehi 3074 24 septal septal JJ cord-335975-m6lkrehi 3074 25 dyskinesia dyskinesia NN cord-335975-m6lkrehi 3074 26 . . . cord-335975-m6lkrehi 3075 1 However however RB cord-335975-m6lkrehi 3075 2 , , , cord-335975-m6lkrehi 3075 3 systolic systolic JJ cord-335975-m6lkrehi 3075 4 dysfunction dysfunction NN cord-335975-m6lkrehi 3075 5 defined define VBN cord-335975-m6lkrehi 3075 6 by by IN cord-335975-m6lkrehi 3075 7 the the DT cord-335975-m6lkrehi 3075 8 guidelines guideline NNS cord-335975-m6lkrehi 3075 9 of of IN cord-335975-m6lkrehi 3075 10 the the DT cord-335975-m6lkrehi 3075 11 American American NNP cord-335975-m6lkrehi 3075 12 Society Society NNP cord-335975-m6lkrehi 3075 13 of of IN cord-335975-m6lkrehi 3075 14 Echocardiography Echocardiography NNP cord-335975-m6lkrehi 3075 15 has have VBZ cord-335975-m6lkrehi 3075 16 not not RB cord-335975-m6lkrehi 3075 17 been be VBN cord-335975-m6lkrehi 3075 18 well well RB cord-335975-m6lkrehi 3075 19 studied study VBN cord-335975-m6lkrehi 3075 20 in in IN cord-335975-m6lkrehi 3075 21 ARDS ARDS NNP cord-335975-m6lkrehi 3075 22 and and CC cord-335975-m6lkrehi 3075 23 in in IN cord-335975-m6lkrehi 3075 24 particular particular JJ cord-335975-m6lkrehi 3075 25 concerning concern VBG cord-335975-m6lkrehi 3075 26 the the DT cord-335975-m6lkrehi 3075 27 RV RV NNP cord-335975-m6lkrehi 3075 28 free free JJ cord-335975-m6lkrehi 3075 29 wall wall NN cord-335975-m6lkrehi 3075 30 longitudinal longitudinal JJ cord-335975-m6lkrehi 3075 31 strain strain NN cord-335975-m6lkrehi 3075 32 ( ( -LRB- cord-335975-m6lkrehi 3075 33 RV RV NNP cord-335975-m6lkrehi 3075 34 - - HYPH cord-335975-m6lkrehi 3075 35 FW FW NNP cord-335975-m6lkrehi 3075 36 - - HYPH cord-335975-m6lkrehi 3075 37 LS LS NNP cord-335975-m6lkrehi 3075 38 ) ) -RRB- cord-335975-m6lkrehi 3075 39 . . . cord-335975-m6lkrehi 3076 1 The the DT cord-335975-m6lkrehi 3076 2 aims aim NNS cord-335975-m6lkrehi 3076 3 of of IN cord-335975-m6lkrehi 3076 4 the the DT cord-335975-m6lkrehi 3076 5 present present JJ cord-335975-m6lkrehi 3076 6 study study NN cord-335975-m6lkrehi 3076 7 were be VBD cord-335975-m6lkrehi 3076 8 to to TO cord-335975-m6lkrehi 3076 9 identify identify VB cord-335975-m6lkrehi 3076 10 the the DT cord-335975-m6lkrehi 3076 11 prevalence prevalence NN cord-335975-m6lkrehi 3076 12 of of IN cord-335975-m6lkrehi 3076 13 RV RV NNP cord-335975-m6lkrehi 3076 14 systolic systolic JJ cord-335975-m6lkrehi 3076 15 dysfunction dysfunction NN cord-335975-m6lkrehi 3076 16 and and CC cord-335975-m6lkrehi 3076 17 ACP ACP NNP cord-335975-m6lkrehi 3076 18 in in IN cord-335975-m6lkrehi 3076 19 ARDS ARDS NNP cord-335975-m6lkrehi 3076 20 , , , cord-335975-m6lkrehi 3076 21 and and CC cord-335975-m6lkrehi 3076 22 to to TO cord-335975-m6lkrehi 3076 23 evaluate evaluate VB cord-335975-m6lkrehi 3076 24 the the DT cord-335975-m6lkrehi 3076 25 effects effect NNS cord-335975-m6lkrehi 3076 26 of of IN cord-335975-m6lkrehi 3076 27 inhaled inhale VBN cord-335975-m6lkrehi 3076 28 nitric nitric NN cord-335975-m6lkrehi 3076 29 oxide oxide NN cord-335975-m6lkrehi 3076 30 ( ( -LRB- cord-335975-m6lkrehi 3076 31 NOi NOi NNP cord-335975-m6lkrehi 3076 32 ) ) -RRB- cord-335975-m6lkrehi 3076 33 and and CC cord-335975-m6lkrehi 3076 34 prone prone JJ cord-335975-m6lkrehi 3076 35 positioning positioning NN cord-335975-m6lkrehi 3076 36 . . . cord-335975-m6lkrehi 3077 1 We -PRON- PRP cord-335975-m6lkrehi 3077 2 prospectively prospectively RB cord-335975-m6lkrehi 3077 3 included include VBD cord-335975-m6lkrehi 3077 4 patients patient NNS cord-335975-m6lkrehi 3077 5 to to IN cord-335975-m6lkrehi 3077 6 a a DT cord-335975-m6lkrehi 3077 7 mild mild JJ cord-335975-m6lkrehi 3077 8 to to IN cord-335975-m6lkrehi 3077 9 severe severe JJ cord-335975-m6lkrehi 3077 10 ARDS ARDS NNP cord-335975-m6lkrehi 3077 11 , , , cord-335975-m6lkrehi 3077 12 and and CC cord-335975-m6lkrehi 3077 13 proceeded proceed VBD cord-335975-m6lkrehi 3077 14 to to IN cord-335975-m6lkrehi 3077 15 standardization standardization NN cord-335975-m6lkrehi 3077 16 of of IN cord-335975-m6lkrehi 3077 17 ventilation ventilation NN cord-335975-m6lkrehi 3077 18 and and CC cord-335975-m6lkrehi 3077 19 systematic systematic JJ cord-335975-m6lkrehi 3077 20 echocardiography echocardiography NN cord-335975-m6lkrehi 3077 21 in in IN cord-335975-m6lkrehi 3077 22 semirecumbent semirecumbent NN cord-335975-m6lkrehi 3077 23 position position NN cord-335975-m6lkrehi 3077 24 , , , cord-335975-m6lkrehi 3077 25 with with IN cord-335975-m6lkrehi 3077 26 NOi noi NN cord-335975-m6lkrehi 3077 27 and and CC cord-335975-m6lkrehi 3077 28 in in IN cord-335975-m6lkrehi 3077 29 prone prone JJ cord-335975-m6lkrehi 3077 30 position position NN cord-335975-m6lkrehi 3077 31 . . . cord-335975-m6lkrehi 3078 1 Interpretation interpretation NN cord-335975-m6lkrehi 3078 2 of of IN cord-335975-m6lkrehi 3078 3 examination examination NN cord-335975-m6lkrehi 3078 4 was be VBD cord-335975-m6lkrehi 3078 5 blinded blind VBN cord-335975-m6lkrehi 3078 6 to to IN cord-335975-m6lkrehi 3078 7 the the DT cord-335975-m6lkrehi 3078 8 investigator investigator NN cord-335975-m6lkrehi 3078 9 . . . cord-335975-m6lkrehi 3079 1 We -PRON- PRP cord-335975-m6lkrehi 3079 2 evaluated evaluate VBD cord-335975-m6lkrehi 3079 3 the the DT cord-335975-m6lkrehi 3079 4 presence presence NN cord-335975-m6lkrehi 3079 5 of of IN cord-335975-m6lkrehi 3079 6 ACP ACP NNP cord-335975-m6lkrehi 3079 7 , , , cord-335975-m6lkrehi 3079 8 systolic systolic JJ cord-335975-m6lkrehi 3079 9 dysfunction dysfunction NN cord-335975-m6lkrehi 3079 10 identified identify VBN cord-335975-m6lkrehi 3079 11 by by IN cord-335975-m6lkrehi 3079 12 classical classical JJ cord-335975-m6lkrehi 3079 13 cardiologic cardiologic NN cord-335975-m6lkrehi 3079 14 criteria criterion NNS cord-335975-m6lkrehi 3079 15 ( ( -LRB- cord-335975-m6lkrehi 3079 16 RV RV NNP cord-335975-m6lkrehi 3079 17 fractional fractional JJ cord-335975-m6lkrehi 3079 18 area area NN cord-335975-m6lkrehi 3079 19 change change NN cord-335975-m6lkrehi 3079 20 , , , cord-335975-m6lkrehi 3079 21 RV RV NNP cord-335975-m6lkrehi 3079 22 Tei Tei NNP cord-335975-m6lkrehi 3079 23 index index NN cord-335975-m6lkrehi 3079 24 , , , cord-335975-m6lkrehi 3079 25 Tricuspid Tricuspid NNP cord-335975-m6lkrehi 3079 26 annular annular JJ cord-335975-m6lkrehi 3079 27 plane plane NN cord-335975-m6lkrehi 3079 28 systolic systolic JJ cord-335975-m6lkrehi 3079 29 excursion excursion NN cord-335975-m6lkrehi 3079 30 , , , cord-335975-m6lkrehi 3079 31 Velocity Velocity NNP cord-335975-m6lkrehi 3079 32 of of IN cord-335975-m6lkrehi 3079 33 the the DT cord-335975-m6lkrehi 3079 34 tricuspid tricuspid JJ cord-335975-m6lkrehi 3079 35 annular annular JJ cord-335975-m6lkrehi 3079 36 systolic systolic JJ cord-335975-m6lkrehi 3079 37 motion motion NN cord-335975-m6lkrehi 3079 38 ) ) -RRB- cord-335975-m6lkrehi 3079 39 and and CC cord-335975-m6lkrehi 3079 40 also also RB cord-335975-m6lkrehi 3079 41 by by IN cord-335975-m6lkrehi 3079 42 RV RV NNP cord-335975-m6lkrehi 3079 43 - - HYPH cord-335975-m6lkrehi 3079 44 FW FW NNP cord-335975-m6lkrehi 3079 45 - - HYPH cord-335975-m6lkrehi 3079 46 LS LS NNP cord-335975-m6lkrehi 3079 47 . . . cord-335975-m6lkrehi 3080 1 Results result NNS cord-335975-m6lkrehi 3080 2 : : : cord-335975-m6lkrehi 3081 1 Sixteen sixteen CD cord-335975-m6lkrehi 3081 2 patients patient NNS cord-335975-m6lkrehi 3081 3 were be VBD cord-335975-m6lkrehi 3081 4 included include VBN cord-335975-m6lkrehi 3081 5 . . . cord-335975-m6lkrehi 3082 1 Thirty thirty CD cord-335975-m6lkrehi 3082 2 - - HYPH cord-335975-m6lkrehi 3082 3 seven seven CD cord-335975-m6lkrehi 3082 4 percent percent NN cord-335975-m6lkrehi 3082 5 of of IN cord-335975-m6lkrehi 3082 6 patients patient NNS cord-335975-m6lkrehi 3082 7 were be VBD cord-335975-m6lkrehi 3082 8 in in IN cord-335975-m6lkrehi 3082 9 severe severe JJ cord-335975-m6lkrehi 3082 10 ARDS ARDS NNP cord-335975-m6lkrehi 3082 11 . . . cord-335975-m6lkrehi 3083 1 The the DT cord-335975-m6lkrehi 3083 2 prevalence prevalence NN cord-335975-m6lkrehi 3083 3 of of IN cord-335975-m6lkrehi 3083 4 ACP ACP NNP cord-335975-m6lkrehi 3083 5 was be VBD cord-335975-m6lkrehi 3083 6 25 25 CD cord-335975-m6lkrehi 3083 7 % % NN cord-335975-m6lkrehi 3083 8 while while IN cord-335975-m6lkrehi 3083 9 right right JJ cord-335975-m6lkrehi 3083 10 ventricular ventricular JJ cord-335975-m6lkrehi 3083 11 systolic systolic JJ cord-335975-m6lkrehi 3083 12 dysfunction dysfunction NN cord-335975-m6lkrehi 3083 13 was be VBD cord-335975-m6lkrehi 3083 14 identified identify VBN cord-335975-m6lkrehi 3083 15 in in IN cord-335975-m6lkrehi 3083 16 37.5 37.5 CD cord-335975-m6lkrehi 3083 17 % % NN cord-335975-m6lkrehi 3083 18 of of IN cord-335975-m6lkrehi 3083 19 patients patient NNS cord-335975-m6lkrehi 3083 20 with with IN cord-335975-m6lkrehi 3083 21 the the DT cord-335975-m6lkrehi 3083 22 classic classic JJ cord-335975-m6lkrehi 3083 23 cardiologic cardiologic JJ cord-335975-m6lkrehi 3083 24 criteria criterion NNS cord-335975-m6lkrehi 3083 25 and and CC cord-335975-m6lkrehi 3083 26 68.7 68.7 CD cord-335975-m6lkrehi 3083 27 % % NN cord-335975-m6lkrehi 3083 28 with with IN cord-335975-m6lkrehi 3083 29 the the DT cord-335975-m6lkrehi 3083 30 impairment impairment NN cord-335975-m6lkrehi 3083 31 of of IN cord-335975-m6lkrehi 3083 32 RV RV NNP cord-335975-m6lkrehi 3083 33 - - HYPH cord-335975-m6lkrehi 3083 34 FW FW NNP cord-335975-m6lkrehi 3083 35 - - HYPH cord-335975-m6lkrehi 3083 36 LS LS NNP cord-335975-m6lkrehi 3083 37 which which WDT cord-335975-m6lkrehi 3083 38 represented represent VBD cord-335975-m6lkrehi 3083 39 the the DT cord-335975-m6lkrehi 3083 40 most most RBS cord-335975-m6lkrehi 3083 41 sensitive sensitive JJ cord-335975-m6lkrehi 3083 42 test test NN cord-335975-m6lkrehi 3083 43 for for IN cord-335975-m6lkrehi 3083 44 right right JJ cord-335975-m6lkrehi 3083 45 ventricular ventricular JJ cord-335975-m6lkrehi 3083 46 dysfunction dysfunction NN cord-335975-m6lkrehi 3083 47 detection detection NN cord-335975-m6lkrehi 3083 48 ( ( -LRB- cord-335975-m6lkrehi 3083 49 Table table NN cord-335975-m6lkrehi 3083 50 1 1 CD cord-335975-m6lkrehi 3083 51 ) ) -RRB- cord-335975-m6lkrehi 3084 1 Introduction introduction NN cord-335975-m6lkrehi 3084 2 : : : cord-335975-m6lkrehi 3085 1 The the DT cord-335975-m6lkrehi 3085 2 use use NN cord-335975-m6lkrehi 3085 3 of of IN cord-335975-m6lkrehi 3085 4 Extra Extra NNP cord-335975-m6lkrehi 3085 5 Corporeal Corporeal NNP cord-335975-m6lkrehi 3085 6 Membrane membrane NN cord-335975-m6lkrehi 3085 7 Oxygenation oxygenation NN cord-335975-m6lkrehi 3085 8 ( ( -LRB- cord-335975-m6lkrehi 3085 9 ECMO ECMO NNP cord-335975-m6lkrehi 3085 10 ) ) -RRB- cord-335975-m6lkrehi 3085 11 is be VBZ cord-335975-m6lkrehi 3085 12 increasing increase VBG cord-335975-m6lkrehi 3085 13 . . . cord-335975-m6lkrehi 3086 1 Brain brain NN cord-335975-m6lkrehi 3086 2 complications complication NNS cord-335975-m6lkrehi 3086 3 may may MD cord-335975-m6lkrehi 3086 4 occur occur VB cord-335975-m6lkrehi 3086 5 , , , cord-335975-m6lkrehi 3086 6 resulting result VBG cord-335975-m6lkrehi 3086 7 in in IN cord-335975-m6lkrehi 3086 8 an an DT cord-335975-m6lkrehi 3086 9 increased increase VBN cord-335975-m6lkrehi 3086 10 morbidity morbidity NN cord-335975-m6lkrehi 3086 11 and and CC cord-335975-m6lkrehi 3086 12 mortality mortality NN cord-335975-m6lkrehi 3086 13 . . . cord-335975-m6lkrehi 3087 1 The the DT cord-335975-m6lkrehi 3087 2 objective objective NN cord-335975-m6lkrehi 3087 3 of of IN cord-335975-m6lkrehi 3087 4 our -PRON- PRP$ cord-335975-m6lkrehi 3087 5 study study NN cord-335975-m6lkrehi 3087 6 was be VBD cord-335975-m6lkrehi 3087 7 to to TO cord-335975-m6lkrehi 3087 8 analyze analyze VB cord-335975-m6lkrehi 3087 9 the the DT cord-335975-m6lkrehi 3087 10 incidence incidence NN cord-335975-m6lkrehi 3087 11 of of IN cord-335975-m6lkrehi 3087 12 neurological neurological JJ cord-335975-m6lkrehi 3087 13 complications complication NNS cord-335975-m6lkrehi 3087 14 while while IN cord-335975-m6lkrehi 3087 15 receiving receive VBG cord-335975-m6lkrehi 3087 16 ECMO ECMO NNP cord-335975-m6lkrehi 3087 17 , , , cord-335975-m6lkrehi 3087 18 the the DT cord-335975-m6lkrehi 3087 19 risk risk NN cord-335975-m6lkrehi 3087 20 factors factor NNS cord-335975-m6lkrehi 3087 21 , , , cord-335975-m6lkrehi 3087 22 and and CC cord-335975-m6lkrehi 3087 23 to to TO cord-335975-m6lkrehi 3087 24 describe describe VB cord-335975-m6lkrehi 3087 25 morbidity morbidity NN cord-335975-m6lkrehi 3087 26 and and CC cord-335975-m6lkrehi 3087 27 mortality mortality NN cord-335975-m6lkrehi 3087 28 in in IN cord-335975-m6lkrehi 3087 29 a a DT cord-335975-m6lkrehi 3087 30 large large JJ cord-335975-m6lkrehi 3087 31 cohort cohort NN cord-335975-m6lkrehi 3087 32 of of IN cord-335975-m6lkrehi 3087 33 patients patient NNS cord-335975-m6lkrehi 3087 34 in in IN cord-335975-m6lkrehi 3087 35 intensive intensive JJ cord-335975-m6lkrehi 3087 36 care care NN cord-335975-m6lkrehi 3087 37 unit unit NN cord-335975-m6lkrehi 3087 38 . . . cord-335975-m6lkrehi 3088 1 Patients patient NNS cord-335975-m6lkrehi 3088 2 and and CC cord-335975-m6lkrehi 3088 3 methods method NNS cord-335975-m6lkrehi 3089 1 : : : cord-335975-m6lkrehi 3089 2 This this DT cord-335975-m6lkrehi 3089 3 was be VBD cord-335975-m6lkrehi 3089 4 an an DT cord-335975-m6lkrehi 3089 5 observational observational JJ cord-335975-m6lkrehi 3089 6 , , , cord-335975-m6lkrehi 3089 7 mono mono NN cord-335975-m6lkrehi 3089 8 - - HYPH cord-335975-m6lkrehi 3089 9 centric centric JJ cord-335975-m6lkrehi 3089 10 , , , cord-335975-m6lkrehi 3089 11 2-year 2-year JJ cord-335975-m6lkrehi 3089 12 retrospective retrospective JJ cord-335975-m6lkrehi 3089 13 study study NN cord-335975-m6lkrehi 3089 14 in in IN cord-335975-m6lkrehi 3089 15 patients patient NNS cord-335975-m6lkrehi 3089 16 who who WP cord-335975-m6lkrehi 3089 17 received receive VBD cord-335975-m6lkrehi 3089 18 ECMO ECMO NNP cord-335975-m6lkrehi 3089 19 . . . cord-335975-m6lkrehi 3090 1 Primary primary JJ cord-335975-m6lkrehi 3090 2 outcome outcome NN cord-335975-m6lkrehi 3090 3 was be VBD cord-335975-m6lkrehi 3090 4 the the DT cord-335975-m6lkrehi 3090 5 occurrence occurrence NN cord-335975-m6lkrehi 3090 6 of of IN cord-335975-m6lkrehi 3090 7 neurological neurological JJ cord-335975-m6lkrehi 3090 8 complication complication NN cord-335975-m6lkrehi 3090 9 until until IN cord-335975-m6lkrehi 3090 10 D7 d7 NN cord-335975-m6lkrehi 3090 11 after after IN cord-335975-m6lkrehi 3090 12 ECMO ECMO NNP cord-335975-m6lkrehi 3090 13 . . . cord-335975-m6lkrehi 3091 1 Results result NNS cord-335975-m6lkrehi 3091 2 : : : cord-335975-m6lkrehi 3092 1 One one CD cord-335975-m6lkrehi 3092 2 hundred hundred CD cord-335975-m6lkrehi 3092 3 and and CC cord-335975-m6lkrehi 3092 4 eight eight CD cord-335975-m6lkrehi 3092 5 patients patient NNS cord-335975-m6lkrehi 3092 6 were be VBD cord-335975-m6lkrehi 3092 7 included include VBN cord-335975-m6lkrehi 3092 8 in in IN cord-335975-m6lkrehi 3092 9 the the DT cord-335975-m6lkrehi 3092 10 analysis analysis NN cord-335975-m6lkrehi 3092 11 . . . cord-335975-m6lkrehi 3093 1 Twenty twenty CD cord-335975-m6lkrehi 3093 2 - - HYPH cord-335975-m6lkrehi 3093 3 seven seven CD cord-335975-m6lkrehi 3093 4 patients patient NNS cord-335975-m6lkrehi 3093 5 ( ( -LRB- cord-335975-m6lkrehi 3093 6 25 25 CD cord-335975-m6lkrehi 3093 7 % % NN cord-335975-m6lkrehi 3093 8 ) ) -RRB- cord-335975-m6lkrehi 3093 9 presented present VBD cord-335975-m6lkrehi 3093 10 a a DT cord-335975-m6lkrehi 3093 11 neurological neurological JJ cord-335975-m6lkrehi 3093 12 complication complication NN cord-335975-m6lkrehi 3093 13 . . . cord-335975-m6lkrehi 3094 1 Of of IN cord-335975-m6lkrehi 3094 2 these these DT cord-335975-m6lkrehi 3094 3 , , , cord-335975-m6lkrehi 3094 4 16 16 CD cord-335975-m6lkrehi 3094 5 died die VBD cord-335975-m6lkrehi 3094 6 at at IN cord-335975-m6lkrehi 3094 7 D30 D30 NNP cord-335975-m6lkrehi 3094 8 . . . cord-335975-m6lkrehi 3095 1 There there EX cord-335975-m6lkrehi 3095 2 were be VBD cord-335975-m6lkrehi 3095 3 13 13 CD cord-335975-m6lkrehi 3095 4 ischemic ischemic JJ cord-335975-m6lkrehi 3095 5 sequelae sequela NNS cord-335975-m6lkrehi 3095 6 ( ( -LRB- cord-335975-m6lkrehi 3095 7 24.5 24.5 CD cord-335975-m6lkrehi 3095 8 % % NN cord-335975-m6lkrehi 3095 9 ) ) -RRB- cord-335975-m6lkrehi 3095 10 , , , cord-335975-m6lkrehi 3095 11 5 5 CD cord-335975-m6lkrehi 3095 12 intracranial intracranial JJ cord-335975-m6lkrehi 3095 13 haemorrhages haemorrhage NNS cord-335975-m6lkrehi 3095 14 ( ( -LRB- cord-335975-m6lkrehi 3095 15 9.4 9.4 CD cord-335975-m6lkrehi 3095 16 % % NN cord-335975-m6lkrehi 3095 17 ) ) -RRB- cord-335975-m6lkrehi 3095 18 , , , cord-335975-m6lkrehi 3095 19 4 4 CD cord-335975-m6lkrehi 3095 20 cerebral cerebral JJ cord-335975-m6lkrehi 3095 21 edema edema NN cord-335975-m6lkrehi 3095 22 ( ( -LRB- cord-335975-m6lkrehi 3095 23 7.6 7.6 CD cord-335975-m6lkrehi 3095 24 % % NN cord-335975-m6lkrehi 3095 25 ) ) -RRB- cord-335975-m6lkrehi 3095 26 and and CC cord-335975-m6lkrehi 3095 27 one one CD cord-335975-m6lkrehi 3095 28 other other JJ cord-335975-m6lkrehi 3095 29 lesion lesion NN cord-335975-m6lkrehi 3095 30 ( ( -LRB- cord-335975-m6lkrehi 3095 31 1.9 1.9 CD cord-335975-m6lkrehi 3095 32 % % NN cord-335975-m6lkrehi 3095 33 ) ) -RRB- cord-335975-m6lkrehi 3095 34 . . . cord-335975-m6lkrehi 3096 1 The the DT cord-335975-m6lkrehi 3096 2 median median JJ cord-335975-m6lkrehi 3096 3 time time NN cord-335975-m6lkrehi 3096 4 before before IN cord-335975-m6lkrehi 3096 5 occurence occurence NN cord-335975-m6lkrehi 3096 6 of of IN cord-335975-m6lkrehi 3096 7 a a DT cord-335975-m6lkrehi 3096 8 neurological neurological JJ cord-335975-m6lkrehi 3096 9 complication complication NN cord-335975-m6lkrehi 3096 10 was be VBD cord-335975-m6lkrehi 3096 11 8 8 CD cord-335975-m6lkrehi 3096 12 days day NNS cord-335975-m6lkrehi 3096 13 after after IN cord-335975-m6lkrehi 3096 14 the the DT cord-335975-m6lkrehi 3096 15 implementation implementation NN cord-335975-m6lkrehi 3096 16 of of IN cord-335975-m6lkrehi 3096 17 ECMO ECMO NNP cord-335975-m6lkrehi 3096 18 . . . cord-335975-m6lkrehi 3097 1 Multivariate multivariate JJ cord-335975-m6lkrehi 3097 2 analysis analysis NN cord-335975-m6lkrehi 3097 3 revealed reveal VBD cord-335975-m6lkrehi 3097 4 the the DT cord-335975-m6lkrehi 3097 5 presence presence NN cord-335975-m6lkrehi 3097 6 of of IN cord-335975-m6lkrehi 3097 7 hyperlactatemia hyperlactatemia NNP cord-335975-m6lkrehi 3097 8 > > XX cord-335975-m6lkrehi 3097 9 5.4 5.4 CD cord-335975-m6lkrehi 3097 10 mmol mmol JJ cord-335975-m6lkrehi 3097 11 L l NN cord-335975-m6lkrehi 3097 12 , , , cord-335975-m6lkrehi 3097 13 neurological neurological JJ cord-335975-m6lkrehi 3097 14 deficit deficit NN cord-335975-m6lkrehi 3097 15 at at IN cord-335975-m6lkrehi 3097 16 the the DT cord-335975-m6lkrehi 3097 17 beginning beginning NN cord-335975-m6lkrehi 3097 18 of of IN cord-335975-m6lkrehi 3097 19 the the DT cord-335975-m6lkrehi 3097 20 management management NN cord-335975-m6lkrehi 3097 21 , , , cord-335975-m6lkrehi 3097 22 as as RB cord-335975-m6lkrehi 3097 23 well well RB cord-335975-m6lkrehi 3097 24 as as IN cord-335975-m6lkrehi 3097 25 the the DT cord-335975-m6lkrehi 3097 26 history history NN cord-335975-m6lkrehi 3097 27 of of IN cord-335975-m6lkrehi 3097 28 stroke stroke NN cord-335975-m6lkrehi 3097 29 before before IN cord-335975-m6lkrehi 3097 30 the the DT cord-335975-m6lkrehi 3097 31 ECMO ECMO NNP cord-335975-m6lkrehi 3097 32 implementation implementation NN cord-335975-m6lkrehi 3097 33 as as IN cord-335975-m6lkrehi 3097 34 predictive predictive JJ cord-335975-m6lkrehi 3097 35 factors factor NNS cord-335975-m6lkrehi 3097 36 of of IN cord-335975-m6lkrehi 3097 37 neurological neurological JJ cord-335975-m6lkrehi 3097 38 complication complication NN cord-335975-m6lkrehi 3097 39 ( ( -LRB- cord-335975-m6lkrehi 3097 40 OR or CC cord-335975-m6lkrehi 3097 41 44.15 44.15 CD cord-335975-m6lkrehi 3097 42 , , , cord-335975-m6lkrehi 3097 43 . . . cord-335975-m6lkrehi 3098 1 The the DT cord-335975-m6lkrehi 3098 2 incidence incidence NN cord-335975-m6lkrehi 3098 3 of of IN cord-335975-m6lkrehi 3098 4 neurological neurological JJ cord-335975-m6lkrehi 3098 5 complications complication NNS cord-335975-m6lkrehi 3098 6 under under IN cord-335975-m6lkrehi 3098 7 ECMO ECMO NNP cord-335975-m6lkrehi 3098 8 is be VBZ cord-335975-m6lkrehi 3098 9 about about RB cord-335975-m6lkrehi 3098 10 25 25 CD cord-335975-m6lkrehi 3098 11 % % NN cord-335975-m6lkrehi 3098 12 and and CC cord-335975-m6lkrehi 3098 13 ischemic ischemic JJ cord-335975-m6lkrehi 3098 14 sequelae sequela NNS cord-335975-m6lkrehi 3098 15 are be VBP cord-335975-m6lkrehi 3098 16 the the DT cord-335975-m6lkrehi 3098 17 most most RBS cord-335975-m6lkrehi 3098 18 frequent frequent JJ cord-335975-m6lkrehi 3098 19 . . . cord-335975-m6lkrehi 3099 1 History history NN cord-335975-m6lkrehi 3099 2 of of IN cord-335975-m6lkrehi 3099 3 stroke stroke NN cord-335975-m6lkrehi 3099 4 and and CC cord-335975-m6lkrehi 3099 5 low low JJ cord-335975-m6lkrehi 3099 6 cerebral cerebral JJ cord-335975-m6lkrehi 3099 7 flow flow NN cord-335975-m6lkrehi 3099 8 associated associate VBN cord-335975-m6lkrehi 3099 9 with with IN cord-335975-m6lkrehi 3099 10 ischemia ischemia NN cord-335975-m6lkrehi 3099 11 - - HYPH cord-335975-m6lkrehi 3099 12 reperfusion reperfusion NN cord-335975-m6lkrehi 3099 13 seem seem VBP cord-335975-m6lkrehi 3099 14 to to TO cord-335975-m6lkrehi 3099 15 increase increase VB cord-335975-m6lkrehi 3099 16 the the DT cord-335975-m6lkrehi 3099 17 occurrence occurrence NN cord-335975-m6lkrehi 3099 18 of of IN cord-335975-m6lkrehi 3099 19 these these DT cord-335975-m6lkrehi 3099 20 complications complication NNS cord-335975-m6lkrehi 3099 21 and and CC cord-335975-m6lkrehi 3099 22 must must MD cord-335975-m6lkrehi 3099 23 lead lead VB cord-335975-m6lkrehi 3099 24 to to IN cord-335975-m6lkrehi 3099 25 greater great JJR cord-335975-m6lkrehi 3099 26 vigilance vigilance NN cord-335975-m6lkrehi 3099 27 in in IN cord-335975-m6lkrehi 3099 28 these these DT cord-335975-m6lkrehi 3099 29 patients patient NNS cord-335975-m6lkrehi 3099 30 . . . cord-335975-m6lkrehi 3100 1 -122 -122 NNP cord-335975-m6lkrehi 3100 2 ] ] -RRB- cord-335975-m6lkrehi 3100 3 . . . cord-335975-m6lkrehi 3101 1 Eighteen eighteen CD cord-335975-m6lkrehi 3101 2 patients patient NNS cord-335975-m6lkrehi 3101 3 ( ( -LRB- cord-335975-m6lkrehi 3101 4 16 16 CD cord-335975-m6lkrehi 3101 5 % % NN cord-335975-m6lkrehi 3101 6 ) ) -RRB- cord-335975-m6lkrehi 3101 7 survived survive VBD cord-335975-m6lkrehi 3101 8 at at IN cord-335975-m6lkrehi 3101 9 ICU ICU NNP cord-335975-m6lkrehi 3101 10 discharge discharge NN cord-335975-m6lkrehi 3101 11 with with IN cord-335975-m6lkrehi 3101 12 a a DT cord-335975-m6lkrehi 3101 13 good good JJ cord-335975-m6lkrehi 3101 14 neurological neurological JJ cord-335975-m6lkrehi 3101 15 outcome outcome NN cord-335975-m6lkrehi 3101 16 . . . cord-335975-m6lkrehi 3102 1 By by IN cord-335975-m6lkrehi 3102 2 multivariate multivariate JJ cord-335975-m6lkrehi 3102 3 logistic logistic JJ cord-335975-m6lkrehi 3102 4 regression regression NN cord-335975-m6lkrehi 3102 5 analysis analysis NN cord-335975-m6lkrehi 3102 6 , , , cord-335975-m6lkrehi 3102 7 female female JJ cord-335975-m6lkrehi 3102 8 sex sex NN cord-335975-m6lkrehi 3102 9 , , , cord-335975-m6lkrehi 3102 10 initial initial JJ cord-335975-m6lkrehi 3102 11 shockable shockable JJ cord-335975-m6lkrehi 3102 12 rhythm rhythm NN cord-335975-m6lkrehi 3102 13 , , , cord-335975-m6lkrehi 3102 14 and and CC cord-335975-m6lkrehi 3102 15 pre pre JJ cord-335975-m6lkrehi 3102 16 - - JJ cord-335975-m6lkrehi 3102 17 ECMO ecmo JJ cord-335975-m6lkrehi 3102 18 arterial arterial JJ cord-335975-m6lkrehi 3102 19 blood blood NN cord-335975-m6lkrehi 3103 1 pH pH NNP cord-335975-m6lkrehi 3103 2 ≥ ≥ NNP cord-335975-m6lkrehi 3103 3 7.1 7.1 CD cord-335975-m6lkrehi 3103 4 were be VBD cord-335975-m6lkrehi 3103 5 independent independent JJ cord-335975-m6lkrehi 3103 6 predictors predictor NNS cord-335975-m6lkrehi 3103 7 of of IN cord-335975-m6lkrehi 3103 8 survival survival NN cord-335975-m6lkrehi 3103 9 with with IN cord-335975-m6lkrehi 3103 10 good good JJ cord-335975-m6lkrehi 3103 11 neurological neurological JJ cord-335975-m6lkrehi 3103 12 outcome outcome NN cord-335975-m6lkrehi 3103 13 . . . cord-335975-m6lkrehi 3104 1 All all DT cord-335975-m6lkrehi 3104 2 of of IN cord-335975-m6lkrehi 3104 3 the the DT cord-335975-m6lkrehi 3104 4 patients patient NNS cord-335975-m6lkrehi 3104 5 presenting present VBG cord-335975-m6lkrehi 3104 6 with with IN cord-335975-m6lkrehi 3104 7 CPC CPC NNP cord-335975-m6lkrehi 3104 8 score score NN cord-335975-m6lkrehi 3104 9 of of IN cord-335975-m6lkrehi 3104 10 1 1 CD cord-335975-m6lkrehi 3104 11 or or CC cord-335975-m6lkrehi 3104 12 2 2 CD cord-335975-m6lkrehi 3104 13 at at IN cord-335975-m6lkrehi 3104 14 ICU ICU NNP cord-335975-m6lkrehi 3104 15 discharge discharge NN cord-335975-m6lkrehi 3104 16 had have VBD cord-335975-m6lkrehi 3104 17 a a DT cord-335975-m6lkrehi 3104 18 shockable shockable JJ cord-335975-m6lkrehi 3104 19 rhythm rhythm NN cord-335975-m6lkrehi 3104 20 and and CC cord-335975-m6lkrehi 3104 21 or or CC cord-335975-m6lkrehi 3104 22 pH ph NN cord-335975-m6lkrehi 3104 23 ≥ ≥ NNP cord-335975-m6lkrehi 3104 24 7.1 7.1 CD cord-335975-m6lkrehi 3104 25 before before IN cord-335975-m6lkrehi 3104 26 ECLS ECLS NNP cord-335975-m6lkrehi 3104 27 implantation implantation NN cord-335975-m6lkrehi 3104 28 . . . cord-335975-m6lkrehi 3105 1 28 28 CD cord-335975-m6lkrehi 3105 2 % % NN cord-335975-m6lkrehi 3105 3 of of IN cord-335975-m6lkrehi 3105 4 the the DT cord-335975-m6lkrehi 3105 5 patients patient NNS cord-335975-m6lkrehi 3105 6 presenting present VBG cord-335975-m6lkrehi 3105 7 with with IN cord-335975-m6lkrehi 3105 8 these these DT cord-335975-m6lkrehi 3105 9 criteria criterion NNS cord-335975-m6lkrehi 3105 10 had have VBD cord-335975-m6lkrehi 3105 11 a a DT cord-335975-m6lkrehi 3105 12 good good JJ cord-335975-m6lkrehi 3105 13 neurological neurological JJ cord-335975-m6lkrehi 3105 14 outcome outcome NN cord-335975-m6lkrehi 3105 15 at at IN cord-335975-m6lkrehi 3105 16 ICU ICU NNP cord-335975-m6lkrehi 3105 17 discharge discharge NN cord-335975-m6lkrehi 3105 18 . . . cord-335975-m6lkrehi 3106 1 All all DT cord-335975-m6lkrehi 3106 2 of of IN cord-335975-m6lkrehi 3106 3 the the DT cord-335975-m6lkrehi 3106 4 patients patient NNS cord-335975-m6lkrehi 3106 5 presenting present VBG cord-335975-m6lkrehi 3106 6 with with IN cord-335975-m6lkrehi 3106 7 non non JJ cord-335975-m6lkrehi 3106 8 - - JJ cord-335975-m6lkrehi 3106 9 shockable shockable JJ cord-335975-m6lkrehi 3106 10 rhythm rhythm NN cord-335975-m6lkrehi 3106 11 and and CC cord-335975-m6lkrehi 3106 12 pH ph NN cord-335975-m6lkrehi 3106 13 < < XX cord-335975-m6lkrehi 3106 14 7.1 7.1 CD cord-335975-m6lkrehi 3106 15 before before IN cord-335975-m6lkrehi 3106 16 ECLS ECLS NNP cord-335975-m6lkrehi 3106 17 implantation implantation NN cord-335975-m6lkrehi 3106 18 died die VBD cord-335975-m6lkrehi 3106 19 in in IN cord-335975-m6lkrehi 3106 20 the the DT cord-335975-m6lkrehi 3106 21 ICU ICU NNP cord-335975-m6lkrehi 3106 22 . . . cord-335975-m6lkrehi 3107 1 Conclusion conclusion NN cord-335975-m6lkrehi 3107 2 : : : cord-335975-m6lkrehi 3107 3 About about RB cord-335975-m6lkrehi 3107 4 one one CD cord-335975-m6lkrehi 3107 5 third third NN cord-335975-m6lkrehi 3107 6 of of IN cord-335975-m6lkrehi 3107 7 the the DT cord-335975-m6lkrehi 3107 8 patients patient NNS cord-335975-m6lkrehi 3107 9 presenting present VBG cord-335975-m6lkrehi 3107 10 with with IN cord-335975-m6lkrehi 3107 11 shockable shockable JJ cord-335975-m6lkrehi 3107 12 rhythm rhythm NN cord-335975-m6lkrehi 3107 13 and and CC cord-335975-m6lkrehi 3107 14 or or CC cord-335975-m6lkrehi 3107 15 pH ph NN cord-335975-m6lkrehi 3107 16 ≥ ≥ NNP cord-335975-m6lkrehi 3107 17 7.1 7.1 CD cord-335975-m6lkrehi 3107 18 before before IN cord-335975-m6lkrehi 3107 19 ECLS ECLS NNP cord-335975-m6lkrehi 3107 20 implantation implantation NN cord-335975-m6lkrehi 3107 21 had have VBD cord-335975-m6lkrehi 3107 22 a a DT cord-335975-m6lkrehi 3107 23 good good JJ cord-335975-m6lkrehi 3107 24 neurological neurological JJ cord-335975-m6lkrehi 3107 25 outcome outcome NN cord-335975-m6lkrehi 3107 26 at at IN cord-335975-m6lkrehi 3107 27 ICU ICU NNP cord-335975-m6lkrehi 3107 28 discharge discharge NN cord-335975-m6lkrehi 3107 29 . . . cord-335975-m6lkrehi 3108 1 On on IN cord-335975-m6lkrehi 3108 2 the the DT cord-335975-m6lkrehi 3108 3 contrary contrary NN cord-335975-m6lkrehi 3108 4 , , , cord-335975-m6lkrehi 3108 5 all all DT cord-335975-m6lkrehi 3108 6 of of IN cord-335975-m6lkrehi 3108 7 the the DT cord-335975-m6lkrehi 3108 8 patients patient NNS cord-335975-m6lkrehi 3108 9 presenting present VBG cord-335975-m6lkrehi 3108 10 with with IN cord-335975-m6lkrehi 3108 11 both both DT cord-335975-m6lkrehi 3108 12 non non JJ cord-335975-m6lkrehi 3108 13 - - JJ cord-335975-m6lkrehi 3108 14 shockable shockable JJ cord-335975-m6lkrehi 3108 15 rhythm rhythm NN cord-335975-m6lkrehi 3108 16 and and CC cord-335975-m6lkrehi 3108 17 pH ph NN cord-335975-m6lkrehi 3108 18 < < XX cord-335975-m6lkrehi 3108 19 7.1 7.1 CD cord-335975-m6lkrehi 3108 20 before before IN cord-335975-m6lkrehi 3108 21 ECLS ECLS NNP cord-335975-m6lkrehi 3108 22 implantation implantation NN cord-335975-m6lkrehi 3108 23 died die VBD cord-335975-m6lkrehi 3108 24 in in IN cord-335975-m6lkrehi 3108 25 the the DT cord-335975-m6lkrehi 3108 26 ICU ICU NNP cord-335975-m6lkrehi 3108 27 . . . cord-335975-m6lkrehi 3109 1 These these DT cord-335975-m6lkrehi 3109 2 simple simple JJ cord-335975-m6lkrehi 3109 3 parameters parameter NNS cord-335975-m6lkrehi 3109 4 might may MD cord-335975-m6lkrehi 3109 5 help help VB cord-335975-m6lkrehi 3109 6 to to TO cord-335975-m6lkrehi 3109 7 identify identify VB cord-335975-m6lkrehi 3109 8 cardiac cardiac JJ cord-335975-m6lkrehi 3109 9 arrest arrest NN cord-335975-m6lkrehi 3109 10 patients patient NNS cord-335975-m6lkrehi 3109 11 which which WDT cord-335975-m6lkrehi 3109 12 could could MD cord-335975-m6lkrehi 3109 13 benefit benefit VB cord-335975-m6lkrehi 3109 14 from from IN cord-335975-m6lkrehi 3109 15 ECLS ECLS NNP cord-335975-m6lkrehi 3109 16 implantation implantation NN cord-335975-m6lkrehi 3109 17 . . . cord-335975-m6lkrehi 3110 1 Radjou Radjou NNP cord-335975-m6lkrehi 3110 2 Aguila Aguila NNP cord-335975-m6lkrehi 3110 3 Introduction introduction NN cord-335975-m6lkrehi 3110 4 : : : cord-335975-m6lkrehi 3111 1 The the DT cord-335975-m6lkrehi 3111 2 decrease decrease NN cord-335975-m6lkrehi 3111 3 of of IN cord-335975-m6lkrehi 3111 4 lung lung NN cord-335975-m6lkrehi 3111 5 volume volume NN cord-335975-m6lkrehi 3111 6 is be VBZ cord-335975-m6lkrehi 3111 7 a a DT cord-335975-m6lkrehi 3111 8 keystone keystone NN cord-335975-m6lkrehi 3111 9 for for IN cord-335975-m6lkrehi 3111 10 the the DT cord-335975-m6lkrehi 3111 11 management management NN cord-335975-m6lkrehi 3111 12 of of IN cord-335975-m6lkrehi 3111 13 patients patient NNS cord-335975-m6lkrehi 3111 14 under under IN cord-335975-m6lkrehi 3111 15 mechanical mechanical JJ cord-335975-m6lkrehi 3111 16 ventilation ventilation NN cord-335975-m6lkrehi 3111 17 in in IN cord-335975-m6lkrehi 3111 18 intensive intensive JJ cord-335975-m6lkrehi 3111 19 care care NN cord-335975-m6lkrehi 3111 20 units unit NNS cord-335975-m6lkrehi 3111 21 . . . cord-335975-m6lkrehi 3112 1 This this DT cord-335975-m6lkrehi 3112 2 procedure procedure NN cord-335975-m6lkrehi 3112 3 has have VBZ cord-335975-m6lkrehi 3112 4 not not RB cord-335975-m6lkrehi 3112 5 only only RB cord-335975-m6lkrehi 3112 6 led lead VBN cord-335975-m6lkrehi 3112 7 to to IN cord-335975-m6lkrehi 3112 8 a a DT cord-335975-m6lkrehi 3112 9 reduction reduction NN cord-335975-m6lkrehi 3112 10 of of IN cord-335975-m6lkrehi 3112 11 morbimortality morbimortality NN cord-335975-m6lkrehi 3112 12 in in IN cord-335975-m6lkrehi 3112 13 ARDS ARDS NNP cord-335975-m6lkrehi 3112 14 but but CC cord-335975-m6lkrehi 3112 15 also also RB cord-335975-m6lkrehi 3112 16 in in IN cord-335975-m6lkrehi 3112 17 all all DT cord-335975-m6lkrehi 3112 18 patients patient NNS cord-335975-m6lkrehi 3112 19 mechanicaly mechanicaly RB cord-335975-m6lkrehi 3112 20 ventilated ventilate VBN cord-335975-m6lkrehi 3112 21 in in IN cord-335975-m6lkrehi 3112 22 intensive intensive JJ cord-335975-m6lkrehi 3112 23 care care NN cord-335975-m6lkrehi 3112 24 units unit NNS cord-335975-m6lkrehi 3112 25 as as RB cord-335975-m6lkrehi 3112 26 well well RB cord-335975-m6lkrehi 3112 27 as as IN cord-335975-m6lkrehi 3112 28 in in IN cord-335975-m6lkrehi 3112 29 major major JJ cord-335975-m6lkrehi 3112 30 surjery surjery NN cord-335975-m6lkrehi 3112 31 . . . cord-335975-m6lkrehi 3113 1 Nevertheless nevertheless RB cord-335975-m6lkrehi 3113 2 , , , cord-335975-m6lkrehi 3113 3 the the DT cord-335975-m6lkrehi 3113 4 incidence incidence NN cord-335975-m6lkrehi 3113 5 of of IN cord-335975-m6lkrehi 3113 6 high high JJ cord-335975-m6lkrehi 3113 7 volume volume NN cord-335975-m6lkrehi 3113 8 ( ( -LRB- cord-335975-m6lkrehi 3113 9 VT VT NNP cord-335975-m6lkrehi 3113 10 ) ) -RRB- cord-335975-m6lkrehi 3113 11 on on IN cord-335975-m6lkrehi 3113 12 morbimortality morbimortality NN cord-335975-m6lkrehi 3113 13 is be VBZ cord-335975-m6lkrehi 3113 14 extremely extremely RB cord-335975-m6lkrehi 3113 15 variable variable JJ cord-335975-m6lkrehi 3113 16 ( ( -LRB- cord-335975-m6lkrehi 3113 17 about about RB cord-335975-m6lkrehi 3113 18 8 8 CD cord-335975-m6lkrehi 3113 19 to to TO cord-335975-m6lkrehi 3113 20 70 70 CD cord-335975-m6lkrehi 3113 21 % % NN cord-335975-m6lkrehi 3113 22 ) ) -RRB- cord-335975-m6lkrehi 3113 23 . . . cord-335975-m6lkrehi 3114 1 Our -PRON- PRP$ cord-335975-m6lkrehi 3114 2 main main JJ cord-335975-m6lkrehi 3114 3 objective objective NN cord-335975-m6lkrehi 3114 4 is be VBZ cord-335975-m6lkrehi 3114 5 to to TO cord-335975-m6lkrehi 3114 6 assess assess VB cord-335975-m6lkrehi 3114 7 the the DT cord-335975-m6lkrehi 3114 8 incidence incidence NN cord-335975-m6lkrehi 3114 9 of of IN cord-335975-m6lkrehi 3114 10 high high JJ cord-335975-m6lkrehi 3114 11 volume volume NN cord-335975-m6lkrehi 3114 12 ventilation ventilation NN cord-335975-m6lkrehi 3114 13 ( ( -LRB- cord-335975-m6lkrehi 3114 14 > > NFP cord-335975-m6lkrehi 3114 15 8 8 CD cord-335975-m6lkrehi 3114 16 ml ml NNS cord-335975-m6lkrehi 3114 17 / / SYM cord-335975-m6lkrehi 3114 18 kg kg NNS cord-335975-m6lkrehi 3114 19 predicted predict VBD cord-335975-m6lkrehi 3114 20 body body NN cord-335975-m6lkrehi 3114 21 weight weight NN cord-335975-m6lkrehi 3114 22 , , , cord-335975-m6lkrehi 3114 23 PBW PBW NNP cord-335975-m6lkrehi 3114 24 ) ) -RRB- cord-335975-m6lkrehi 3114 25 in in IN cord-335975-m6lkrehi 3114 26 our -PRON- PRP$ cord-335975-m6lkrehi 3114 27 hospital hospital NN cord-335975-m6lkrehi 3114 28 intensive intensive JJ cord-335975-m6lkrehi 3114 29 care care NN cord-335975-m6lkrehi 3114 30 units unit NNS cord-335975-m6lkrehi 3114 31 . . . cord-335975-m6lkrehi 3115 1 Moreover moreover RB cord-335975-m6lkrehi 3115 2 we -PRON- PRP cord-335975-m6lkrehi 3115 3 were be VBD cord-335975-m6lkrehi 3115 4 interested interested JJ cord-335975-m6lkrehi 3115 5 in in IN cord-335975-m6lkrehi 3115 6 determining determine VBG cord-335975-m6lkrehi 3115 7 the the DT cord-335975-m6lkrehi 3115 8 risk risk NN cord-335975-m6lkrehi 3115 9 factors factor NNS cord-335975-m6lkrehi 3115 10 of of IN cord-335975-m6lkrehi 3115 11 high high JJ cord-335975-m6lkrehi 3115 12 volume volume NN cord-335975-m6lkrehi 3115 13 ventilation ventilation NN cord-335975-m6lkrehi 3115 14 . . . cord-335975-m6lkrehi 3116 1 We -PRON- PRP cord-335975-m6lkrehi 3116 2 conducted conduct VBD cord-335975-m6lkrehi 3116 3 a a DT cord-335975-m6lkrehi 3116 4 retrospective retrospective JJ cord-335975-m6lkrehi 3116 5 observational observational JJ cord-335975-m6lkrehi 3116 6 study study NN cord-335975-m6lkrehi 3116 7 from from IN cord-335975-m6lkrehi 3116 8 January January NNP cord-335975-m6lkrehi 3116 9 to to IN cord-335975-m6lkrehi 3116 10 March March NNP cord-335975-m6lkrehi 3116 11 2015 2015 CD cord-335975-m6lkrehi 3116 12 in in IN cord-335975-m6lkrehi 3116 13 three three CD cord-335975-m6lkrehi 3116 14 intensive intensive JJ cord-335975-m6lkrehi 3116 15 care care NN cord-335975-m6lkrehi 3116 16 units unit NNS cord-335975-m6lkrehi 3116 17 of of IN cord-335975-m6lkrehi 3116 18 a a DT cord-335975-m6lkrehi 3116 19 tertiary tertiary JJ cord-335975-m6lkrehi 3116 20 university university NN cord-335975-m6lkrehi 3116 21 hospital hospital NN cord-335975-m6lkrehi 3116 22 . . . cord-335975-m6lkrehi 3117 1 All all DT cord-335975-m6lkrehi 3117 2 patients patient NNS cord-335975-m6lkrehi 3117 3 ventilated ventilate VBN cord-335975-m6lkrehi 3117 4 under under IN cord-335975-m6lkrehi 3117 5 sedation sedation NN cord-335975-m6lkrehi 3117 6 in in IN cord-335975-m6lkrehi 3117 7 VAC vac NN cord-335975-m6lkrehi 3117 8 mode mode NN cord-335975-m6lkrehi 3117 9 during during IN cord-335975-m6lkrehi 3117 10 the the DT cord-335975-m6lkrehi 3117 11 24 24 CD cord-335975-m6lkrehi 3117 12 h h NN cord-335975-m6lkrehi 3117 13 after after IN cord-335975-m6lkrehi 3117 14 admission admission NN cord-335975-m6lkrehi 3117 15 were be VBD cord-335975-m6lkrehi 3117 16 included include VBN cord-335975-m6lkrehi 3117 17 in in IN cord-335975-m6lkrehi 3117 18 the the DT cord-335975-m6lkrehi 3117 19 study study NN cord-335975-m6lkrehi 3117 20 . . . cord-335975-m6lkrehi 3118 1 Of of IN cord-335975-m6lkrehi 3118 2 the the DT cord-335975-m6lkrehi 3118 3 502 502 CD cord-335975-m6lkrehi 3118 4 patients patient NNS cord-335975-m6lkrehi 3118 5 admissions admission NNS cord-335975-m6lkrehi 3118 6 during during IN cord-335975-m6lkrehi 3118 7 the the DT cord-335975-m6lkrehi 3118 8 period period NN cord-335975-m6lkrehi 3118 9 , , , cord-335975-m6lkrehi 3118 10 71 71 CD cord-335975-m6lkrehi 3118 11 one one CD cord-335975-m6lkrehi 3118 12 of of IN cord-335975-m6lkrehi 3118 13 them -PRON- PRP cord-335975-m6lkrehi 3118 14 ( ( -LRB- cord-335975-m6lkrehi 3118 15 14 14 CD cord-335975-m6lkrehi 3118 16 % % NN cord-335975-m6lkrehi 3118 17 ) ) -RRB- cord-335975-m6lkrehi 3118 18 have have VBP cord-335975-m6lkrehi 3118 19 no no DT cord-335975-m6lkrehi 3118 20 height height NN cord-335975-m6lkrehi 3118 21 mentioned mention VBN cord-335975-m6lkrehi 3118 22 in in IN cord-335975-m6lkrehi 3118 23 their -PRON- PRP$ cord-335975-m6lkrehi 3118 24 medical medical JJ cord-335975-m6lkrehi 3118 25 file file NN cord-335975-m6lkrehi 3118 26 and and CC cord-335975-m6lkrehi 3118 27 were be VBD cord-335975-m6lkrehi 3118 28 exluded exlude VBN cord-335975-m6lkrehi 3118 29 . . . cord-335975-m6lkrehi 3119 1 Among among IN cord-335975-m6lkrehi 3119 2 the the DT cord-335975-m6lkrehi 3119 3 351 351 CD cord-335975-m6lkrehi 3119 4 patients patient NNS cord-335975-m6lkrehi 3119 5 considered consider VBN cord-335975-m6lkrehi 3119 6 , , , cord-335975-m6lkrehi 3119 7 110 110 CD cord-335975-m6lkrehi 3119 8 ( ( -LRB- cord-335975-m6lkrehi 3119 9 31.3 31.3 CD cord-335975-m6lkrehi 3119 10 % % NN cord-335975-m6lkrehi 3119 11 ) ) -RRB- cord-335975-m6lkrehi 3119 12 were be VBD cord-335975-m6lkrehi 3119 13 ventilated ventilate VBN cord-335975-m6lkrehi 3119 14 with with IN cord-335975-m6lkrehi 3119 15 high high JJ cord-335975-m6lkrehi 3119 16 VT VT NNP cord-335975-m6lkrehi 3119 17 ( ( -LRB- cord-335975-m6lkrehi 3119 18 Fig Fig NNP cord-335975-m6lkrehi 3119 19 . . . cord-335975-m6lkrehi 3119 20 1 1 CD cord-335975-m6lkrehi 3119 21 ) ) -RRB- cord-335975-m6lkrehi 3119 22 . . . cord-335975-m6lkrehi 3120 1 98 98 CD cord-335975-m6lkrehi 3120 2 % % NN cord-335975-m6lkrehi 3120 3 of of IN cord-335975-m6lkrehi 3120 4 patients patient NNS cord-335975-m6lkrehi 3120 5 had have VBD cord-335975-m6lkrehi 3120 6 a a DT cord-335975-m6lkrehi 3120 7 positive positive JJ cord-335975-m6lkrehi 3120 8 expiratory expiratory JJ cord-335975-m6lkrehi 3120 9 pressure pressure NN cord-335975-m6lkrehi 3120 10 ≥ ≥ CD cord-335975-m6lkrehi 3120 11 4 4 CD cord-335975-m6lkrehi 3120 12 cmH2O. cmH2O. NNP cord-335975-m6lkrehi 3121 1 In in IN cord-335975-m6lkrehi 3121 2 multivariable multivariable JJ cord-335975-m6lkrehi 3121 3 analysis analysis NN cord-335975-m6lkrehi 3121 4 , , , cord-335975-m6lkrehi 3121 5 height height NN cord-335975-m6lkrehi 3121 6 ( ( -LRB- cord-335975-m6lkrehi 3121 7 smaller small JJR cord-335975-m6lkrehi 3121 8 ) ) -RRB- cord-335975-m6lkrehi 3121 9 and and CC cord-335975-m6lkrehi 3121 10 weight weight NN cord-335975-m6lkrehi 3121 11 ( ( -LRB- cord-335975-m6lkrehi 3121 12 lower low JJR cord-335975-m6lkrehi 3121 13 ) ) -RRB- cord-335975-m6lkrehi 3121 14 are be VBP cord-335975-m6lkrehi 3121 15 the the DT cord-335975-m6lkrehi 3121 16 only only JJ cord-335975-m6lkrehi 3121 17 associated associate VBN cord-335975-m6lkrehi 3121 18 factors factor NNS cord-335975-m6lkrehi 3121 19 with with IN cord-335975-m6lkrehi 3121 20 a a DT cord-335975-m6lkrehi 3121 21 high high JJ cord-335975-m6lkrehi 3121 22 volume volume NN cord-335975-m6lkrehi 3121 23 ventilation ventilation NN cord-335975-m6lkrehi 3121 24 ( ( -LRB- cord-335975-m6lkrehi 3121 25 p p NN cord-335975-m6lkrehi 3121 26 < < XX cord-335975-m6lkrehi 3121 27 0.0001 0.0001 CD cord-335975-m6lkrehi 3121 28 and and CC cord-335975-m6lkrehi 3121 29 p p NN cord-335975-m6lkrehi 3121 30 = = SYM cord-335975-m6lkrehi 3121 31 0.015 0.015 CD cord-335975-m6lkrehi 3121 32 , , , cord-335975-m6lkrehi 3121 33 respectively respectively RB cord-335975-m6lkrehi 3121 34 ) ) -RRB- cord-335975-m6lkrehi 3121 35 . . . cord-335975-m6lkrehi 3122 1 Discussion discussion NN cord-335975-m6lkrehi 3122 2 : : : cord-335975-m6lkrehi 3123 1 The the DT cord-335975-m6lkrehi 3123 2 observed observed JJ cord-335975-m6lkrehi 3123 3 incidence incidence NN cord-335975-m6lkrehi 3123 4 on on IN cord-335975-m6lkrehi 3123 5 high high JJ cord-335975-m6lkrehi 3123 6 VT VT NNP cord-335975-m6lkrehi 3123 7 patients patient NNS cord-335975-m6lkrehi 3123 8 is be VBZ cord-335975-m6lkrehi 3123 9 higher high JJR cord-335975-m6lkrehi 3123 10 than than IN cord-335975-m6lkrehi 3123 11 that that DT cord-335975-m6lkrehi 3123 12 reported report VBN cord-335975-m6lkrehi 3123 13 in in IN cord-335975-m6lkrehi 3123 14 most most JJS cord-335975-m6lkrehi 3123 15 papers paper NNS cord-335975-m6lkrehi 3123 16 in in IN cord-335975-m6lkrehi 3123 17 literature literature NN cord-335975-m6lkrehi 3123 18 ( ( -LRB- cord-335975-m6lkrehi 3123 19 Jaber Jaber NNP cord-335975-m6lkrehi 3123 20 et et NNP cord-335975-m6lkrehi 3123 21 al al NNP cord-335975-m6lkrehi 3123 22 . . . cord-335975-m6lkrehi 3124 1 18 18 CD cord-335975-m6lkrehi 3124 2 % % NN cord-335975-m6lkrehi 3124 3 , , , cord-335975-m6lkrehi 3124 4 Hess Hess NNP cord-335975-m6lkrehi 3124 5 et et NNP cord-335975-m6lkrehi 3124 6 al al NNP cord-335975-m6lkrehi 3124 7 . . NNP cord-335975-m6lkrehi 3124 8 8 8 CD cord-335975-m6lkrehi 3124 9 % % NN cord-335975-m6lkrehi 3124 10 ) ) -RRB- cord-335975-m6lkrehi 3124 11 . . . cord-335975-m6lkrehi 3125 1 Nevertheless nevertheless RB cord-335975-m6lkrehi 3125 2 , , , cord-335975-m6lkrehi 3125 3 both both DT cord-335975-m6lkrehi 3125 4 studies study NNS cord-335975-m6lkrehi 3125 5 were be VBD cord-335975-m6lkrehi 3125 6 conducted conduct VBN cord-335975-m6lkrehi 3125 7 in in IN cord-335975-m6lkrehi 3125 8 operating operate VBG cord-335975-m6lkrehi 3125 9 room room NN cord-335975-m6lkrehi 3125 10 with with IN cord-335975-m6lkrehi 3125 11 higher high JJR cord-335975-m6lkrehi 3125 12 VT VT NNP cord-335975-m6lkrehi 3125 13 cut cut VBN cord-335975-m6lkrehi 3125 14 - - HYPH cord-335975-m6lkrehi 3125 15 off off NN cord-335975-m6lkrehi 3125 16 ( ( -LRB- cord-335975-m6lkrehi 3125 17 10 10 CD cord-335975-m6lkrehi 3125 18 ml ml NNS cord-335975-m6lkrehi 3125 19 / / SYM cord-335975-m6lkrehi 3125 20 kg kg NNP cord-335975-m6lkrehi 3125 21 ) ) -RRB- cord-335975-m6lkrehi 3125 22 . . . cord-335975-m6lkrehi 3126 1 Walkey Walkey NNP cord-335975-m6lkrehi 3126 2 and and CC cord-335975-m6lkrehi 3126 3 al al NNP cord-335975-m6lkrehi 3126 4 showed show VBD cord-335975-m6lkrehi 3126 5 that that IN cord-335975-m6lkrehi 3126 6 34 34 CD cord-335975-m6lkrehi 3126 7 % % NN cord-335975-m6lkrehi 3126 8 of of IN cord-335975-m6lkrehi 3126 9 patients patient NNS cord-335975-m6lkrehi 3126 10 in in IN cord-335975-m6lkrehi 3126 11 ARDS ARDS NNP cord-335975-m6lkrehi 3126 12 were be VBD cord-335975-m6lkrehi 3126 13 ventilated ventilate VBN cord-335975-m6lkrehi 3126 14 with with IN cord-335975-m6lkrehi 3126 15 VT VT NNP cord-335975-m6lkrehi 3126 16 › › NNP cord-335975-m6lkrehi 3126 17 8 8 CD cord-335975-m6lkrehi 3126 18 ml ml NNS cord-335975-m6lkrehi 3126 19 / / SYM cord-335975-m6lkrehi 3126 20 kg kg NNS cord-335975-m6lkrehi 3126 21 of of IN cord-335975-m6lkrehi 3126 22 PBW PBW NNP cord-335975-m6lkrehi 3126 23 . . . cord-335975-m6lkrehi 3127 1 Moreover moreover RB cord-335975-m6lkrehi 3127 2 , , , cord-335975-m6lkrehi 3127 3 the the DT cord-335975-m6lkrehi 3127 4 same same JJ cord-335975-m6lkrehi 3127 5 associated associate VBN cord-335975-m6lkrehi 3127 6 factors factor NNS cord-335975-m6lkrehi 3127 7 ( ( -LRB- cord-335975-m6lkrehi 3127 8 smaller small JJR cord-335975-m6lkrehi 3127 9 height height NN cord-335975-m6lkrehi 3127 10 and and CC cord-335975-m6lkrehi 3127 11 lower low JJR cord-335975-m6lkrehi 3127 12 weight weight NN cord-335975-m6lkrehi 3127 13 ) ) -RRB- cord-335975-m6lkrehi 3127 14 have have VBP cord-335975-m6lkrehi 3127 15 found find VBN cord-335975-m6lkrehi 3127 16 in in IN cord-335975-m6lkrehi 3127 17 the the DT cord-335975-m6lkrehi 3127 18 study study NN cord-335975-m6lkrehi 3127 19 . . . cord-335975-m6lkrehi 3128 1 Older old JJR cord-335975-m6lkrehi 3128 2 studies study NNS cord-335975-m6lkrehi 3128 3 revealed reveal VBD cord-335975-m6lkrehi 3128 4 higher high JJR cord-335975-m6lkrehi 3128 5 BMI BMI NNP cord-335975-m6lkrehi 3128 6 as as IN cord-335975-m6lkrehi 3128 7 factor factor NN cord-335975-m6lkrehi 3128 8 to to IN cord-335975-m6lkrehi 3128 9 high high JJ cord-335975-m6lkrehi 3128 10 volume volume NN cord-335975-m6lkrehi 3128 11 ventilation ventilation NN cord-335975-m6lkrehi 3128 12 . . . cord-335975-m6lkrehi 3129 1 This this DT cord-335975-m6lkrehi 3129 2 difference difference NN cord-335975-m6lkrehi 3129 3 could could MD cord-335975-m6lkrehi 3129 4 be be VB cord-335975-m6lkrehi 3129 5 explained explain VBN cord-335975-m6lkrehi 3129 6 by by IN cord-335975-m6lkrehi 3129 7 the the DT cord-335975-m6lkrehi 3129 8 use use NN cord-335975-m6lkrehi 3129 9 of of IN cord-335975-m6lkrehi 3129 10 predicted predict VBN cord-335975-m6lkrehi 3129 11 body body NN cord-335975-m6lkrehi 3129 12 weight weight NN cord-335975-m6lkrehi 3129 13 . . . cord-335975-m6lkrehi 3130 1 Conclusion conclusion NN cord-335975-m6lkrehi 3130 2 : : : cord-335975-m6lkrehi 3131 1 Although although IN cord-335975-m6lkrehi 3131 2 the the DT cord-335975-m6lkrehi 3131 3 growing grow VBG cord-335975-m6lkrehi 3131 4 literature literature NN cord-335975-m6lkrehi 3131 5 and and CC cord-335975-m6lkrehi 3131 6 the the DT cord-335975-m6lkrehi 3131 7 recommandations recommandation NNS cord-335975-m6lkrehi 3131 8 aim aim VBP cord-335975-m6lkrehi 3131 9 to to TO cord-335975-m6lkrehi 3131 10 reduce reduce VB cord-335975-m6lkrehi 3131 11 the the DT cord-335975-m6lkrehi 3131 12 lung lung NN cord-335975-m6lkrehi 3131 13 volume volume NN cord-335975-m6lkrehi 3131 14 between between IN cord-335975-m6lkrehi 3131 15 6 6 CD cord-335975-m6lkrehi 3131 16 to to TO cord-335975-m6lkrehi 3131 17 8 8 CD cord-335975-m6lkrehi 3131 18 ml ml NNS cord-335975-m6lkrehi 3131 19 / / SYM cord-335975-m6lkrehi 3131 20 kg kg NNS cord-335975-m6lkrehi 3131 21 of of IN cord-335975-m6lkrehi 3131 22 PBW PBW NNP cord-335975-m6lkrehi 3131 23 , , , cord-335975-m6lkrehi 3131 24 still still RB cord-335975-m6lkrehi 3131 25 one one CD cord-335975-m6lkrehi 3131 26 third third NN cord-335975-m6lkrehi 3131 27 of of IN cord-335975-m6lkrehi 3131 28 the the DT cord-335975-m6lkrehi 3131 29 patients patient NNS cord-335975-m6lkrehi 3131 30 in in IN cord-335975-m6lkrehi 3131 31 intensive intensive JJ cord-335975-m6lkrehi 3131 32 care care NN cord-335975-m6lkrehi 3131 33 units unit NNS cord-335975-m6lkrehi 3131 34 are be VBP cord-335975-m6lkrehi 3131 35 ventilated ventilate VBN cord-335975-m6lkrehi 3131 36 with with IN cord-335975-m6lkrehi 3131 37 too too RB cord-335975-m6lkrehi 3131 38 high high JJ cord-335975-m6lkrehi 3131 39 lung lung NN cord-335975-m6lkrehi 3131 40 volume volume NN cord-335975-m6lkrehi 3131 41 . . . cord-335975-m6lkrehi 3132 1 ( ( -LRB- cord-335975-m6lkrehi 3132 2 Fig Fig NNP cord-335975-m6lkrehi 3132 3 . . NNP cord-335975-m6lkrehi 3132 4 1 1 CD cord-335975-m6lkrehi 3132 5 ) ) -RRB- cord-335975-m6lkrehi 3132 6 . . . cord-335975-m6lkrehi 3133 1 with with IN cord-335975-m6lkrehi 3133 2 either either CC cord-335975-m6lkrehi 3133 3 a a DT cord-335975-m6lkrehi 3133 4 NC NC NNP cord-335975-m6lkrehi 3133 5 overlap overlap VBP cord-335975-m6lkrehi 3133 6 on on IN cord-335975-m6lkrehi 3133 7 one one CD cord-335975-m6lkrehi 3133 8 nostril nostril NN cord-335975-m6lkrehi 3133 9 or or CC cord-335975-m6lkrehi 3133 10 not not RB cord-335975-m6lkrehi 3133 11 . . . cord-335975-m6lkrehi 3134 1 Results result NNS cord-335975-m6lkrehi 3134 2 : : : cord-335975-m6lkrehi 3135 1 When when WRB cord-335975-m6lkrehi 3135 2 the the DT cord-335975-m6lkrehi 3135 3 MV MV NNP cord-335975-m6lkrehi 3135 4 increases increase VBZ cord-335975-m6lkrehi 3135 5 , , , cord-335975-m6lkrehi 3135 6 the the DT cord-335975-m6lkrehi 3135 7 FiO FiO NNP cord-335975-m6lkrehi 3135 8 2 2 CD cord-335975-m6lkrehi 3135 9 decreases decrease NNS cord-335975-m6lkrehi 3135 10 . . . cord-335975-m6lkrehi 3136 1 When when WRB cord-335975-m6lkrehi 3136 2 the the DT cord-335975-m6lkrehi 3136 3 mouth mouth NN cord-335975-m6lkrehi 3136 4 opens open VBZ cord-335975-m6lkrehi 3136 5 , , , cord-335975-m6lkrehi 3136 6 the the DT cord-335975-m6lkrehi 3136 7 FiO FiO NNP cord-335975-m6lkrehi 3136 8 2 2 CD cord-335975-m6lkrehi 3136 9 decreases decrease NNS cord-335975-m6lkrehi 3136 10 . . . cord-335975-m6lkrehi 3137 1 When when WRB cord-335975-m6lkrehi 3137 2 the the DT cord-335975-m6lkrehi 3137 3 prongs prong NNS cord-335975-m6lkrehi 3137 4 are be VBP cord-335975-m6lkrehi 3137 5 overlapping overlap VBG cord-335975-m6lkrehi 3137 6 one one CD cord-335975-m6lkrehi 3137 7 nostril nostril NN cord-335975-m6lkrehi 3138 1 the the DT cord-335975-m6lkrehi 3138 2 FiO FiO NNP cord-335975-m6lkrehi 3138 3 2 2 CD cord-335975-m6lkrehi 3138 4 decreases decrease VBZ cord-335975-m6lkrehi 3138 5 slightly slightly RB cord-335975-m6lkrehi 3138 6 ( ( -LRB- cord-335975-m6lkrehi 3138 7 mean mean VB cord-335975-m6lkrehi 3138 8 5 5 CD cord-335975-m6lkrehi 3138 9 ± ± CD cord-335975-m6lkrehi 3138 10 2 2 CD cord-335975-m6lkrehi 3138 11 % % NN cord-335975-m6lkrehi 3138 12 in in IN cord-335975-m6lkrehi 3138 13 absolute absolute JJ cord-335975-m6lkrehi 3138 14 value value NN cord-335975-m6lkrehi 3138 15 ) ) -RRB- cord-335975-m6lkrehi 3138 16 . . . cord-335975-m6lkrehi 3139 1 Statistical statistical JJ cord-335975-m6lkrehi 3139 2 differences difference NNS cord-335975-m6lkrehi 3139 3 were be VBD cord-335975-m6lkrehi 3139 4 found find VBN cord-335975-m6lkrehi 3139 5 between between IN cord-335975-m6lkrehi 3139 6 closed closed JJ cord-335975-m6lkrehi 3139 7 and and CC cord-335975-m6lkrehi 3139 8 open open JJ cord-335975-m6lkrehi 3139 9 mouth mouth NN cord-335975-m6lkrehi 3139 10 and and CC cord-335975-m6lkrehi 3139 11 between between IN cord-335975-m6lkrehi 3139 12 overlap overlap NN cord-335975-m6lkrehi 3139 13 on on IN cord-335975-m6lkrehi 3139 14 one one CD cord-335975-m6lkrehi 3139 15 nostril nostril NN cord-335975-m6lkrehi 3139 16 and and CC cord-335975-m6lkrehi 3139 17 not not RB cord-335975-m6lkrehi 3139 18 ( ( -LRB- cord-335975-m6lkrehi 3139 19 p p NN cord-335975-m6lkrehi 3139 20 < < XX cord-335975-m6lkrehi 3139 21 .05 .05 NFP cord-335975-m6lkrehi 3139 22 ) ) -RRB- cord-335975-m6lkrehi 3139 23 , , , cord-335975-m6lkrehi 3139 24 except except IN cord-335975-m6lkrehi 3139 25 between between IN cord-335975-m6lkrehi 3139 26 TMO TMO NNP cord-335975-m6lkrehi 3139 27 and and CC cord-335975-m6lkrehi 3139 28 CM CM NNP cord-335975-m6lkrehi 3139 29 at at IN cord-335975-m6lkrehi 3139 30 two two CD cord-335975-m6lkrehi 3139 31 MV MV NNP cord-335975-m6lkrehi 3139 32 ( ( -LRB- cord-335975-m6lkrehi 3139 33 14 14 CD cord-335975-m6lkrehi 3139 34 and and CC cord-335975-m6lkrehi 3139 35 17 17 CD cord-335975-m6lkrehi 3139 36 L l NN cord-335975-m6lkrehi 3139 37 / / SYM cord-335975-m6lkrehi 3139 38 min min NN cord-335975-m6lkrehi 3139 39 ) ) -RRB- cord-335975-m6lkrehi 3139 40 when when WRB cord-335975-m6lkrehi 3139 41 NC NC NNP cord-335975-m6lkrehi 3139 42 overlap overlap VBP cord-335975-m6lkrehi 3139 43 on on IN cord-335975-m6lkrehi 3139 44 one one CD cord-335975-m6lkrehi 3139 45 nostril nostril NN cord-335975-m6lkrehi 3139 46 ( ( -LRB- cord-335975-m6lkrehi 3139 47 Fig fig NN cord-335975-m6lkrehi 3139 48 . . . cord-335975-m6lkrehi 3139 49 1 1 CD cord-335975-m6lkrehi 3139 50 ) ) -RRB- cord-335975-m6lkrehi 3139 51 . . . cord-335975-m6lkrehi 3140 1 Conclusion conclusion NN cord-335975-m6lkrehi 3140 2 : : : cord-335975-m6lkrehi 3140 3 When when WRB cord-335975-m6lkrehi 3140 4 the the DT cord-335975-m6lkrehi 3140 5 prongs prong NNS cord-335975-m6lkrehi 3140 6 of of IN cord-335975-m6lkrehi 3140 7 NC NC NNP cord-335975-m6lkrehi 3140 8 are be VBP cord-335975-m6lkrehi 3140 9 not not RB cord-335975-m6lkrehi 3140 10 correctly correctly RB cord-335975-m6lkrehi 3140 11 placed place VBN cord-335975-m6lkrehi 3140 12 in in IN cord-335975-m6lkrehi 3140 13 the the DT cord-335975-m6lkrehi 3140 14 nostrils nostril NNS cord-335975-m6lkrehi 3140 15 , , , cord-335975-m6lkrehi 3140 16 the the DT cord-335975-m6lkrehi 3140 17 FiO fio NN cord-335975-m6lkrehi 3140 18 2 2 CD cord-335975-m6lkrehi 3140 19 decreases decrease NNS cord-335975-m6lkrehi 3140 20 , , , cord-335975-m6lkrehi 3140 21 but but CC cord-335975-m6lkrehi 3140 22 this this DT cord-335975-m6lkrehi 3140 23 impact impact NN cord-335975-m6lkrehi 3140 24 is be VBZ cord-335975-m6lkrehi 3140 25 limited limit VBN cord-335975-m6lkrehi 3140 26 in in IN cord-335975-m6lkrehi 3140 27 our -PRON- PRP$ cord-335975-m6lkrehi 3140 28 bench bench NN cord-335975-m6lkrehi 3140 29 study study NN cord-335975-m6lkrehi 3140 30 . . . cord-335975-m6lkrehi 3141 1 The the DT cord-335975-m6lkrehi 3141 2 impact impact NN cord-335975-m6lkrehi 3141 3 of of IN cord-335975-m6lkrehi 3141 4 MV MV NNP cord-335975-m6lkrehi 3141 5 increases increase NNS cord-335975-m6lkrehi 3141 6 and and CC cord-335975-m6lkrehi 3141 7 mouth mouth NN cord-335975-m6lkrehi 3141 8 opening opening NN cord-335975-m6lkrehi 3141 9 on on IN cord-335975-m6lkrehi 3141 10 the the DT cord-335975-m6lkrehi 3141 11 FiO FiO NNS cord-335975-m6lkrehi 3141 12 2 2 CD cord-335975-m6lkrehi 3141 13 values value NNS cord-335975-m6lkrehi 3141 14 is be VBZ cord-335975-m6lkrehi 3141 15 also also RB cord-335975-m6lkrehi 3141 16 important important JJ cord-335975-m6lkrehi 3141 17 . . . cord-335975-m6lkrehi 3142 1 Introduction introduction NN cord-335975-m6lkrehi 3142 2 : : : cord-335975-m6lkrehi 3143 1 The the DT cord-335975-m6lkrehi 3143 2 weaning weaning NN cord-335975-m6lkrehi 3143 3 of of IN cord-335975-m6lkrehi 3143 4 mechanical mechanical JJ cord-335975-m6lkrehi 3143 5 ventilation ventilation NN cord-335975-m6lkrehi 3143 6 is be VBZ cord-335975-m6lkrehi 3143 7 an an DT cord-335975-m6lkrehi 3143 8 essential essential JJ cord-335975-m6lkrehi 3143 9 and and CC cord-335975-m6lkrehi 3143 10 delicate delicate JJ cord-335975-m6lkrehi 3143 11 phase phase NN cord-335975-m6lkrehi 3143 12 in in IN cord-335975-m6lkrehi 3143 13 the the DT cord-335975-m6lkrehi 3143 14 management management NN cord-335975-m6lkrehi 3143 15 of of IN cord-335975-m6lkrehi 3143 16 a a DT cord-335975-m6lkrehi 3143 17 resuscitation resuscitation NN cord-335975-m6lkrehi 3143 18 patient patient NN cord-335975-m6lkrehi 3143 19 . . . cord-335975-m6lkrehi 3144 1 The the DT cord-335975-m6lkrehi 3144 2 neurosurgical neurosurgical JJ cord-335975-m6lkrehi 3144 3 patient patient NN cord-335975-m6lkrehi 3144 4 presents present VBZ cord-335975-m6lkrehi 3144 5 a a DT cord-335975-m6lkrehi 3144 6 number number NN cord-335975-m6lkrehi 3144 7 of of IN cord-335975-m6lkrehi 3144 8 specific specific JJ cord-335975-m6lkrehi 3144 9 problems problem NNS cord-335975-m6lkrehi 3144 10 , , , cord-335975-m6lkrehi 3144 11 such such JJ cord-335975-m6lkrehi 3144 12 as as IN cord-335975-m6lkrehi 3144 13 impaired impaired JJ cord-335975-m6lkrehi 3144 14 control control NN cord-335975-m6lkrehi 3144 15 ventilatory ventilatory JJ cord-335975-m6lkrehi 3144 16 control control NN cord-335975-m6lkrehi 3144 17 , , , cord-335975-m6lkrehi 3144 18 coughing coughing NN cord-335975-m6lkrehi 3144 19 or or CC cord-335975-m6lkrehi 3144 20 the the DT cord-335975-m6lkrehi 3144 21 pharyngo pharyngo JJ cord-335975-m6lkrehi 3144 22 - - HYPH cord-335975-m6lkrehi 3144 23 laryngeal laryngeal NN cord-335975-m6lkrehi 3144 24 intersection intersection NN cord-335975-m6lkrehi 3144 25 . . . cord-335975-m6lkrehi 3145 1 However however RB cord-335975-m6lkrehi 3145 2 , , , cord-335975-m6lkrehi 3145 3 it -PRON- PRP cord-335975-m6lkrehi 3145 4 often often RB cord-335975-m6lkrehi 3145 5 allows allow VBZ cord-335975-m6lkrehi 3145 6 short short JJ cord-335975-m6lkrehi 3145 7 - - HYPH cord-335975-m6lkrehi 3145 8 term term NN cord-335975-m6lkrehi 3145 9 ventilatory ventilatory JJ cord-335975-m6lkrehi 3145 10 withdrawal withdrawal NN cord-335975-m6lkrehi 3145 11 in in IN cord-335975-m6lkrehi 3145 12 the the DT cord-335975-m6lkrehi 3145 13 neurosurgical neurosurgical JJ cord-335975-m6lkrehi 3145 14 patient patient NN cord-335975-m6lkrehi 3145 15 , , , cord-335975-m6lkrehi 3145 16 probably probably RB cord-335975-m6lkrehi 3145 17 largely largely RB cord-335975-m6lkrehi 3145 18 by by IN cord-335975-m6lkrehi 3145 19 the the DT cord-335975-m6lkrehi 3145 20 simple simple JJ cord-335975-m6lkrehi 3145 21 fact fact NN cord-335975-m6lkrehi 3145 22 that that IN cord-335975-m6lkrehi 3145 23 it -PRON- PRP cord-335975-m6lkrehi 3145 24 authorizes authorize VBZ cord-335975-m6lkrehi 3145 25 the the DT cord-335975-m6lkrehi 3145 26 definitive definitive JJ cord-335975-m6lkrehi 3145 27 cessation cessation NN cord-335975-m6lkrehi 3145 28 of of IN cord-335975-m6lkrehi 3145 29 sedation sedation NN cord-335975-m6lkrehi 3145 30 . . . cord-335975-m6lkrehi 3146 1 The the DT cord-335975-m6lkrehi 3146 2 objective objective NN cord-335975-m6lkrehi 3146 3 of of IN cord-335975-m6lkrehi 3146 4 the the DT cord-335975-m6lkrehi 3146 5 study study NN cord-335975-m6lkrehi 3146 6 and and CC cord-335975-m6lkrehi 3146 7 demonstrate demonstrate VB cord-335975-m6lkrehi 3146 8 the the DT cord-335975-m6lkrehi 3146 9 place place NN cord-335975-m6lkrehi 3146 10 of of IN cord-335975-m6lkrehi 3146 11 tracheotomy tracheotomy NN cord-335975-m6lkrehi 3146 12 in in IN cord-335975-m6lkrehi 3146 13 neuro neuro NNP cord-335975-m6lkrehi 3146 14 - - HYPH cord-335975-m6lkrehi 3146 15 resuscitation resuscitation NN cord-335975-m6lkrehi 3146 16 patients patient NNS cord-335975-m6lkrehi 3146 17 , , , cord-335975-m6lkrehi 3146 18 and and CC cord-335975-m6lkrehi 3146 19 prevent prevent VB cord-335975-m6lkrehi 3146 20 its -PRON- PRP$ cord-335975-m6lkrehi 3146 21 complications complication NNS cord-335975-m6lkrehi 3146 22 . . . cord-335975-m6lkrehi 3147 1 A a DT cord-335975-m6lkrehi 3147 2 retrospective retrospective JJ cord-335975-m6lkrehi 3147 3 descriptive descriptive JJ cord-335975-m6lkrehi 3147 4 study study NN cord-335975-m6lkrehi 3147 5 of of IN cord-335975-m6lkrehi 3147 6 597 597 CD cord-335975-m6lkrehi 3147 7 patients patient NNS cord-335975-m6lkrehi 3147 8 hospitalized hospitalize VBN cord-335975-m6lkrehi 3147 9 in in IN cord-335975-m6lkrehi 3147 10 the the DT cord-335975-m6lkrehi 3147 11 neuro neuro NNP cord-335975-m6lkrehi 3147 12 - - HYPH cord-335975-m6lkrehi 3147 13 resuscitation resuscitation NNP cord-335975-m6lkrehi 3147 14 unit unit NN cord-335975-m6lkrehi 3147 15 during during IN cord-335975-m6lkrehi 3147 16 the the DT cord-335975-m6lkrehi 3147 17 period period NN cord-335975-m6lkrehi 3147 18 1 1 CD cord-335975-m6lkrehi 3147 19 January January NNP cord-335975-m6lkrehi 3147 20 to to IN cord-335975-m6lkrehi 3147 21 31 31 CD cord-335975-m6lkrehi 3147 22 December December NNP cord-335975-m6lkrehi 3147 23 2016 2016 CD cord-335975-m6lkrehi 3147 24 , , , cord-335975-m6lkrehi 3147 25 of of IN cord-335975-m6lkrehi 3147 26 which which WDT cord-335975-m6lkrehi 3147 27 113 113 CD cord-335975-m6lkrehi 3147 28 patients patient NNS cord-335975-m6lkrehi 3147 29 benefited benefit VBN cord-335975-m6lkrehi 3147 30 from from IN cord-335975-m6lkrehi 3147 31 surgical surgical JJ cord-335975-m6lkrehi 3147 32 tracheotomy tracheotomy NN cord-335975-m6lkrehi 3147 33 , , , cord-335975-m6lkrehi 3147 34 is be VBZ cord-335975-m6lkrehi 3147 35 a a DT cord-335975-m6lkrehi 3147 36 frequency frequency NN cord-335975-m6lkrehi 3147 37 of of IN cord-335975-m6lkrehi 3147 38 19 19 CD cord-335975-m6lkrehi 3147 39 % % NN cord-335975-m6lkrehi 3147 40 of of IN cord-335975-m6lkrehi 3147 41 all all DT cord-335975-m6lkrehi 3147 42 inpatients inpatient NNS cord-335975-m6lkrehi 3147 43 during during IN cord-335975-m6lkrehi 3147 44 this this DT cord-335975-m6lkrehi 3147 45 period period NN cord-335975-m6lkrehi 3147 46 . . . cord-335975-m6lkrehi 3148 1 Clinical clinical JJ cord-335975-m6lkrehi 3148 2 , , , cord-335975-m6lkrehi 3148 3 para para NN cord-335975-m6lkrehi 3148 4 - - HYPH cord-335975-m6lkrehi 3148 5 clinical clinical JJ cord-335975-m6lkrehi 3148 6 , , , cord-335975-m6lkrehi 3148 7 etiological etiological JJ cord-335975-m6lkrehi 3148 8 , , , cord-335975-m6lkrehi 3148 9 and and CC cord-335975-m6lkrehi 3148 10 therapeutic therapeutic JJ cord-335975-m6lkrehi 3148 11 data datum NNS cord-335975-m6lkrehi 3148 12 were be VBD cord-335975-m6lkrehi 3148 13 collected collect VBN cord-335975-m6lkrehi 3148 14 from from IN cord-335975-m6lkrehi 3148 15 hospitalization hospitalization NN cord-335975-m6lkrehi 3148 16 records record NNS cord-335975-m6lkrehi 3148 17 . . . cord-335975-m6lkrehi 3149 1 In in IN cord-335975-m6lkrehi 3149 2 a a DT cord-335975-m6lkrehi 3149 3 series series NN cord-335975-m6lkrehi 3149 4 of of IN cord-335975-m6lkrehi 3149 5 597 597 CD cord-335975-m6lkrehi 3149 6 hospitalized hospitalize VBN cord-335975-m6lkrehi 3149 7 patients patient NNS cord-335975-m6lkrehi 3149 8 , , , cord-335975-m6lkrehi 3149 9 during during IN cord-335975-m6lkrehi 3149 10 the the DT cord-335975-m6lkrehi 3149 11 defined define VBN cord-335975-m6lkrehi 3149 12 period period NN cord-335975-m6lkrehi 3149 13 , , , cord-335975-m6lkrehi 3149 14 113 113 CD cord-335975-m6lkrehi 3149 15 patients patient NNS cord-335975-m6lkrehi 3149 16 had have VBD cord-335975-m6lkrehi 3149 17 surgical surgical JJ cord-335975-m6lkrehi 3149 18 tracheotomy tracheotomy NN cord-335975-m6lkrehi 3149 19 , , , cord-335975-m6lkrehi 3149 20 a a DT cord-335975-m6lkrehi 3149 21 frequency frequency NN cord-335975-m6lkrehi 3149 22 of of IN cord-335975-m6lkrehi 3149 23 19 19 CD cord-335975-m6lkrehi 3149 24 % % NN cord-335975-m6lkrehi 3149 25 , , , cord-335975-m6lkrehi 3149 26 in in IN cord-335975-m6lkrehi 3149 27 the the DT cord-335975-m6lkrehi 3149 28 literature literature NN cord-335975-m6lkrehi 3149 29 two two CD cord-335975-m6lkrehi 3149 30 studies study NNS cord-335975-m6lkrehi 3149 31 or or CC cord-335975-m6lkrehi 3149 32 the the DT cord-335975-m6lkrehi 3149 33 data datum NNS cord-335975-m6lkrehi 3149 34 were be VBD cord-335975-m6lkrehi 3149 35 extremely extremely RB cord-335975-m6lkrehi 3149 36 variable variable JJ cord-335975-m6lkrehi 3149 37 , , , cord-335975-m6lkrehi 3149 38 with with IN cord-335975-m6lkrehi 3149 39 29 29 CD cord-335975-m6lkrehi 3149 40 % % NN cord-335975-m6lkrehi 3149 41 in in IN cord-335975-m6lkrehi 3149 42 the the DT cord-335975-m6lkrehi 3149 43 study study NN cord-335975-m6lkrehi 3149 44 Namen Namen NNP cord-335975-m6lkrehi 3149 45 versus versus IN cord-335975-m6lkrehi 3149 46 2.9 2.9 CD cord-335975-m6lkrehi 3149 47 % % NN cord-335975-m6lkrehi 3149 48 in in IN cord-335975-m6lkrehi 3149 49 the the DT cord-335975-m6lkrehi 3149 50 Coplin Coplin NNP cord-335975-m6lkrehi 3149 51 study study NN cord-335975-m6lkrehi 3149 52 . . . cord-335975-m6lkrehi 3150 1 Of of IN cord-335975-m6lkrehi 3150 2 the the DT cord-335975-m6lkrehi 3150 3 113 113 CD cord-335975-m6lkrehi 3150 4 tracheotomies tracheotomy NNS cord-335975-m6lkrehi 3150 5 , , , cord-335975-m6lkrehi 3150 6 6 6 CD cord-335975-m6lkrehi 3150 7 were be VBD cord-335975-m6lkrehi 3150 8 performed perform VBN cord-335975-m6lkrehi 3150 9 by by IN cord-335975-m6lkrehi 3150 10 neurosurgeons neurosurgeon NNS cord-335975-m6lkrehi 3150 11 , , , cord-335975-m6lkrehi 3150 12 and and CC cord-335975-m6lkrehi 3150 13 107 107 CD cord-335975-m6lkrehi 3150 14 by by IN cord-335975-m6lkrehi 3150 15 resuscitators resuscitator NNS cord-335975-m6lkrehi 3150 16 at at IN cord-335975-m6lkrehi 3150 17 a a DT cord-335975-m6lkrehi 3150 18 frequency frequency NN cord-335975-m6lkrehi 3150 19 of of IN cord-335975-m6lkrehi 3150 20 95 95 CD cord-335975-m6lkrehi 3150 21 % % NN cord-335975-m6lkrehi 3150 22 . . . cord-335975-m6lkrehi 3151 1 The the DT cord-335975-m6lkrehi 3151 2 tracheotomy tracheotomy NN cord-335975-m6lkrehi 3151 3 was be VBD cord-335975-m6lkrehi 3151 4 performed perform VBN cord-335975-m6lkrehi 3151 5 on on IN cord-335975-m6lkrehi 3151 6 average average JJ cord-335975-m6lkrehi 3151 7 7 7 CD cord-335975-m6lkrehi 3151 8 days day NNS cord-335975-m6lkrehi 3151 9 after after IN cord-335975-m6lkrehi 3151 10 the the DT cord-335975-m6lkrehi 3151 11 intubation intubation NN cord-335975-m6lkrehi 3151 12 of of IN cord-335975-m6lkrehi 3151 13 the the DT cord-335975-m6lkrehi 3151 14 patients patient NNS cord-335975-m6lkrehi 3151 15 , , , cord-335975-m6lkrehi 3151 16 after after IN cord-335975-m6lkrehi 3151 17 verification verification NN cord-335975-m6lkrehi 3151 18 of of IN cord-335975-m6lkrehi 3151 19 the the DT cord-335975-m6lkrehi 3151 20 impossibility impossibility NN cord-335975-m6lkrehi 3151 21 of of IN cord-335975-m6lkrehi 3151 22 the the DT cord-335975-m6lkrehi 3151 23 extubation extubation NN cord-335975-m6lkrehi 3151 24 of of IN cord-335975-m6lkrehi 3151 25 the the DT cord-335975-m6lkrehi 3151 26 latter latter JJ cord-335975-m6lkrehi 3151 27 either either CC cord-335975-m6lkrehi 3151 28 for for IN cord-335975-m6lkrehi 3151 29 central central JJ cord-335975-m6lkrehi 3151 30 affection affection NN cord-335975-m6lkrehi 3151 31 of of IN cord-335975-m6lkrehi 3151 32 the the DT cord-335975-m6lkrehi 3151 33 ventilatory ventilatory JJ cord-335975-m6lkrehi 3151 34 controls control NNS cord-335975-m6lkrehi 3151 35 , , , cord-335975-m6lkrehi 3151 36 or or CC cord-335975-m6lkrehi 3151 37 reached reach VBD cord-335975-m6lkrehi 3151 38 the the DT cord-335975-m6lkrehi 3151 39 mixed mixed JJ cord-335975-m6lkrehi 3151 40 nerves nerve NNS cord-335975-m6lkrehi 3151 41 and and CC cord-335975-m6lkrehi 3151 42 disorders disorder NNS cord-335975-m6lkrehi 3151 43 of of IN cord-335975-m6lkrehi 3151 44 the the DT cord-335975-m6lkrehi 3151 45 laryngo laryngo NNS cord-335975-m6lkrehi 3151 46 - - HYPH cord-335975-m6lkrehi 3151 47 pharyngeal pharyngeal JJ cord-335975-m6lkrehi 3151 48 intersection intersection NN cord-335975-m6lkrehi 3151 49 and and CC cord-335975-m6lkrehi 3151 50 according accord VBG cord-335975-m6lkrehi 3151 51 to to IN cord-335975-m6lkrehi 3151 52 expert expert JJ cord-335975-m6lkrehi 3151 53 recommendations recommendation NNS cord-335975-m6lkrehi 3151 54 in in IN cord-335975-m6lkrehi 3151 55 2017-Tracheotomy 2017-tracheotomy CD cord-335975-m6lkrehi 3151 56 should should MD cord-335975-m6lkrehi 3151 57 not not RB cord-335975-m6lkrehi 3151 58 be be VB cord-335975-m6lkrehi 3151 59 performed perform VBN cord-335975-m6lkrehi 3151 60 in in IN cord-335975-m6lkrehi 3151 61 the the DT cord-335975-m6lkrehi 3151 62 intensive intensive JJ cord-335975-m6lkrehi 3151 63 care care NN cord-335975-m6lkrehi 3151 64 unit unit NN cord-335975-m6lkrehi 3151 65 before before IN cord-335975-m6lkrehi 3151 66 the the DT cord-335975-m6lkrehi 3151 67 fourth fourth JJ cord-335975-m6lkrehi 3151 68 day day NN cord-335975-m6lkrehi 3151 69 of of IN cord-335975-m6lkrehi 3151 70 mechanical mechanical JJ cord-335975-m6lkrehi 3151 71 ventilation ventilation NN cord-335975-m6lkrehi 3151 72 . . . cord-335975-m6lkrehi 3152 1 Different different JJ cord-335975-m6lkrehi 3152 2 pathologies pathology NNS cord-335975-m6lkrehi 3152 3 that that WDT cord-335975-m6lkrehi 3152 4 patients patient NNS cord-335975-m6lkrehi 3152 5 suffered suffer VBD cord-335975-m6lkrehi 3152 6 and and CC cord-335975-m6lkrehi 3152 7 required require VBD cord-335975-m6lkrehi 3152 8 tracheotomy tracheotomy NN cord-335975-m6lkrehi 3152 9 were be VBD cord-335975-m6lkrehi 3152 10 : : : cord-335975-m6lkrehi 3152 11 post post JJ cord-335975-m6lkrehi 3152 12 - - JJ cord-335975-m6lkrehi 3152 13 operative operative JJ cord-335975-m6lkrehi 3152 14 complications complication NNS cord-335975-m6lkrehi 3152 15 of of IN cord-335975-m6lkrehi 3152 16 brain brain NN cord-335975-m6lkrehi 3152 17 tumors tumor NNS cord-335975-m6lkrehi 3152 18 ( ( -LRB- cord-335975-m6lkrehi 3152 19 brain brain NN cord-335975-m6lkrehi 3152 20 stem stem NN cord-335975-m6lkrehi 3152 21 and and CC cord-335975-m6lkrehi 3152 22 mixed mixed JJ cord-335975-m6lkrehi 3152 23 nerves nerve NNS cord-335975-m6lkrehi 3152 24 ) ) -RRB- cord-335975-m6lkrehi 3152 25 with with IN cord-335975-m6lkrehi 3152 26 52 52 CD cord-335975-m6lkrehi 3152 27 patients patient NNS cord-335975-m6lkrehi 3152 28 , , , cord-335975-m6lkrehi 3152 29 a a DT cord-335975-m6lkrehi 3152 30 rate rate NN cord-335975-m6lkrehi 3152 31 of of IN cord-335975-m6lkrehi 3152 32 46 46 CD cord-335975-m6lkrehi 3152 33 % % NN cord-335975-m6lkrehi 3152 34 , , , cord-335975-m6lkrehi 3152 35 vascular vascular JJ cord-335975-m6lkrehi 3152 36 pathologies pathology NNS cord-335975-m6lkrehi 3152 37 ( ( -LRB- cord-335975-m6lkrehi 3152 38 stroke stroke NN cord-335975-m6lkrehi 3152 39 and and CC cord-335975-m6lkrehi 3152 40 CVT CVT NNP cord-335975-m6lkrehi 3152 41 ) ) -RRB- cord-335975-m6lkrehi 3152 42 ) ) -RRB- cord-335975-m6lkrehi 3152 43 , , , cord-335975-m6lkrehi 3152 44 with with IN cord-335975-m6lkrehi 3152 45 32 32 CD cord-335975-m6lkrehi 3152 46 patients patient NNS cord-335975-m6lkrehi 3152 47 ( ( -LRB- cord-335975-m6lkrehi 3152 48 28 28 CD cord-335975-m6lkrehi 3152 49 % % NN cord-335975-m6lkrehi 3152 50 ) ) -RRB- cord-335975-m6lkrehi 3152 51 , , , cord-335975-m6lkrehi 3152 52 traumatic traumatic JJ cord-335975-m6lkrehi 3152 53 pathologies pathology NNS cord-335975-m6lkrehi 3152 54 , , , cord-335975-m6lkrehi 3152 55 with with IN cord-335975-m6lkrehi 3152 56 29 29 CD cord-335975-m6lkrehi 3152 57 patients patient NNS cord-335975-m6lkrehi 3152 58 ( ( -LRB- cord-335975-m6lkrehi 3152 59 26 26 CD cord-335975-m6lkrehi 3152 60 % % NN cord-335975-m6lkrehi 3152 61 ) ) -RRB- cord-335975-m6lkrehi 3152 62 . . . cord-335975-m6lkrehi 3153 1 21 21 CD cord-335975-m6lkrehi 3153 2 cases case NNS cord-335975-m6lkrehi 3153 3 , , , cord-335975-m6lkrehi 3153 4 19 19 CD cord-335975-m6lkrehi 3153 5 % % NN cord-335975-m6lkrehi 3153 6 , , , cord-335975-m6lkrehi 3153 7 4 4 CD cord-335975-m6lkrehi 3153 8 cases case NNS cord-335975-m6lkrehi 3153 9 of of IN cord-335975-m6lkrehi 3153 10 secondary secondary JJ cord-335975-m6lkrehi 3153 11 bleeding bleeding NN cord-335975-m6lkrehi 3153 12 of of IN cord-335975-m6lkrehi 3153 13 the the DT cord-335975-m6lkrehi 3153 14 orifice orifice NN cord-335975-m6lkrehi 3153 15 , , , cord-335975-m6lkrehi 3153 16 2 2 CD cord-335975-m6lkrehi 3153 17 cases case NNS cord-335975-m6lkrehi 3153 18 of of IN cord-335975-m6lkrehi 3153 19 tracheal tracheal JJ cord-335975-m6lkrehi 3153 20 stenosis stenosis NN cord-335975-m6lkrehi 3153 21 , , , cord-335975-m6lkrehi 3153 22 and and CC cord-335975-m6lkrehi 3153 23 1 1 CD cord-335975-m6lkrehi 3153 24 case case NN cord-335975-m6lkrehi 3153 25 of of IN cord-335975-m6lkrehi 3153 26 tracheomalacia tracheomalacia NNS cord-335975-m6lkrehi 3153 27 . . . cord-335975-m6lkrehi 3154 1 The the DT cord-335975-m6lkrehi 3154 2 decan decan NN cord-335975-m6lkrehi 3154 3 made make VBN cord-335975-m6lkrehi 3154 4 after after IN cord-335975-m6lkrehi 3154 5 pharyngolaryngeal pharyngolaryngeal JJ cord-335975-m6lkrehi 3154 6 neurological neurological JJ cord-335975-m6lkrehi 3154 7 examination examination NN cord-335975-m6lkrehi 3154 8 , , , cord-335975-m6lkrehi 3154 9 and and CC cord-335975-m6lkrehi 3154 10 according accord VBG cord-335975-m6lkrehi 3154 11 to to IN cord-335975-m6lkrehi 3154 12 SFAR SFAR NNP cord-335975-m6lkrehi 3154 13 2017 2017 CD cord-335975-m6lkrehi 3154 14 recommendations recommendation NNS cord-335975-m6lkrehi 3154 15 experts expert NNS cord-335975-m6lkrehi 3154 16 suggest suggest VBP cord-335975-m6lkrehi 3154 17 that that IN cord-335975-m6lkrehi 3154 18 a a DT cord-335975-m6lkrehi 3154 19 multidisciplinary multidisciplinary JJ cord-335975-m6lkrehi 3154 20 decanulation decanulation NN cord-335975-m6lkrehi 3154 21 protocol protocol NN cord-335975-m6lkrehi 3154 22 available available JJ cord-335975-m6lkrehi 3154 23 in in IN cord-335975-m6lkrehi 3154 24 resuscitation resuscitation NN cord-335975-m6lkrehi 3154 25 departments department NNS cord-335975-m6lkrehi 3154 26 . . . cord-335975-m6lkrehi 3155 1 Conclusion conclusion NN cord-335975-m6lkrehi 3155 2 : : : cord-335975-m6lkrehi 3156 1 Tracheotomy tracheotomy NN cord-335975-m6lkrehi 3156 2 in in IN cord-335975-m6lkrehi 3156 3 neuro neuro NNP cord-335975-m6lkrehi 3156 4 - - HYPH cord-335975-m6lkrehi 3156 5 resuscitation resuscitation NN cord-335975-m6lkrehi 3156 6 has have VBZ cord-335975-m6lkrehi 3156 7 its -PRON- PRP$ cord-335975-m6lkrehi 3156 8 place place NN cord-335975-m6lkrehi 3156 9 , , , cord-335975-m6lkrehi 3156 10 especially especially RB cord-335975-m6lkrehi 3156 11 in in IN cord-335975-m6lkrehi 3156 12 view view NN cord-335975-m6lkrehi 3156 13 of of IN cord-335975-m6lkrehi 3156 14 the the DT cord-335975-m6lkrehi 3156 15 different different JJ cord-335975-m6lkrehi 3156 16 complications complication NNS cord-335975-m6lkrehi 3156 17 specific specific JJ cord-335975-m6lkrehi 3156 18 to to IN cord-335975-m6lkrehi 3156 19 this this DT cord-335975-m6lkrehi 3156 20 type type NN cord-335975-m6lkrehi 3156 21 of of IN cord-335975-m6lkrehi 3156 22 patient patient NN cord-335975-m6lkrehi 3156 23 , , , cord-335975-m6lkrehi 3156 24 but but CC cord-335975-m6lkrehi 3156 25 no no DT cord-335975-m6lkrehi 3156 26 study study NN cord-335975-m6lkrehi 3156 27 has have VBZ cord-335975-m6lkrehi 3156 28 demonstrated demonstrate VBN cord-335975-m6lkrehi 3156 29 its -PRON- PRP$ cord-335975-m6lkrehi 3156 30 improvement improvement NN cord-335975-m6lkrehi 3156 31 in in IN cord-335975-m6lkrehi 3156 32 vital vital JJ cord-335975-m6lkrehi 3156 33 prognosis prognosis NN cord-335975-m6lkrehi 3156 34 . . . cord-335975-m6lkrehi 3157 1 Post post JJ cord-335975-m6lkrehi 3157 2 - - JJ cord-335975-m6lkrehi 3157 3 tracheotomy tracheotomy JJ cord-335975-m6lkrehi 3157 4 complications complication NNS cord-335975-m6lkrehi 3157 5 can can MD cord-335975-m6lkrehi 3157 6 be be VB cord-335975-m6lkrehi 3157 7 considerably considerably RB cord-335975-m6lkrehi 3157 8 reduced reduce VBN cord-335975-m6lkrehi 3157 9 if if IN cord-335975-m6lkrehi 3157 10 the the DT cord-335975-m6lkrehi 3157 11 protocols protocol NNS cord-335975-m6lkrehi 3157 12 and and CC cord-335975-m6lkrehi 3157 13 expert expert NN cord-335975-m6lkrehi 3157 14 recommendations recommendation NNS cord-335975-m6lkrehi 3157 15 are be VBP cord-335975-m6lkrehi 3157 16 applied apply VBN cord-335975-m6lkrehi 3157 17 . . . cord-335975-m6lkrehi 3158 1 Introduction introduction NN cord-335975-m6lkrehi 3158 2 : : : cord-335975-m6lkrehi 3158 3 Noninvasive noninvasive JJ cord-335975-m6lkrehi 3158 4 ventilation ventilation NN cord-335975-m6lkrehi 3158 5 ( ( -LRB- cord-335975-m6lkrehi 3158 6 NIV NIV NNP cord-335975-m6lkrehi 3158 7 ) ) -RRB- cord-335975-m6lkrehi 3158 8 in in IN cord-335975-m6lkrehi 3158 9 intensive intensive JJ cord-335975-m6lkrehi 3158 10 care care NN cord-335975-m6lkrehi 3158 11 ( ( -LRB- cord-335975-m6lkrehi 3158 12 ICU ICU NNP cord-335975-m6lkrehi 3158 13 ) ) -RRB- cord-335975-m6lkrehi 3159 1 is be VBZ cord-335975-m6lkrehi 3159 2 associated associate VBN cord-335975-m6lkrehi 3159 3 with with IN cord-335975-m6lkrehi 3159 4 the the DT cord-335975-m6lkrehi 3159 5 occurrence occurrence NN cord-335975-m6lkrehi 3159 6 of of IN cord-335975-m6lkrehi 3159 7 frequent frequent JJ cord-335975-m6lkrehi 3159 8 asynchronies asynchrony NNS cord-335975-m6lkrehi 3159 9 related relate VBN cord-335975-m6lkrehi 3159 10 to to IN cord-335975-m6lkrehi 3159 11 the the DT cord-335975-m6lkrehi 3159 12 leaks leak NNS cord-335975-m6lkrehi 3159 13 around around IN cord-335975-m6lkrehi 3159 14 the the DT cord-335975-m6lkrehi 3159 15 interface interface NN cord-335975-m6lkrehi 3159 16 , , , cord-335975-m6lkrehi 3159 17 mainly mainly RB cord-335975-m6lkrehi 3159 18 auto auto NN cord-335975-m6lkrehi 3159 19 - - HYPH cord-335975-m6lkrehi 3159 20 triggering trigger VBG cord-335975-m6lkrehi 3159 21 and and CC cord-335975-m6lkrehi 3159 22 delayed delay VBN cord-335975-m6lkrehi 3159 23 cycling cycling NN cord-335975-m6lkrehi 3159 24 . . . cord-335975-m6lkrehi 3160 1 Their -PRON- PRP$ cord-335975-m6lkrehi 3160 2 detection detection NN cord-335975-m6lkrehi 3160 3 requires require VBZ cord-335975-m6lkrehi 3160 4 a a DT cord-335975-m6lkrehi 3160 5 respiratory respiratory JJ cord-335975-m6lkrehi 3160 6 muscles muscle NNS cord-335975-m6lkrehi 3160 7 activity activity NN cord-335975-m6lkrehi 3160 8 monitoring monitoring NN cord-335975-m6lkrehi 3160 9 . . . cord-335975-m6lkrehi 3161 1 Diaphragmatic diaphragmatic JJ cord-335975-m6lkrehi 3161 2 ultrasonography ultrasonography NN cord-335975-m6lkrehi 3161 3 is be VBZ cord-335975-m6lkrehi 3161 4 a a DT cord-335975-m6lkrehi 3161 5 simple simple JJ cord-335975-m6lkrehi 3161 6 imaging imaging NN cord-335975-m6lkrehi 3161 7 technique technique NN cord-335975-m6lkrehi 3161 8 available available JJ cord-335975-m6lkrehi 3161 9 at at IN cord-335975-m6lkrehi 3161 10 bedside bedside NN cord-335975-m6lkrehi 3161 11 to to TO cord-335975-m6lkrehi 3161 12 assess assess VB cord-335975-m6lkrehi 3161 13 diaphragm diaphragm NN cord-335975-m6lkrehi 3161 14 motion motion NN cord-335975-m6lkrehi 3161 15 . . . cord-335975-m6lkrehi 3162 1 Whether whether IN cord-335975-m6lkrehi 3162 2 diaphragmatic diaphragmatic JJ cord-335975-m6lkrehi 3162 3 ultrasonography ultrasonography NN cord-335975-m6lkrehi 3162 4 would would MD cord-335975-m6lkrehi 3162 5 allow allow VB cord-335975-m6lkrehi 3162 6 detecting detect VBG cord-335975-m6lkrehi 3162 7 asynchronies asynchrony NNS cord-335975-m6lkrehi 3162 8 due due JJ cord-335975-m6lkrehi 3162 9 to to IN cord-335975-m6lkrehi 3162 10 leaks leak NNS cord-335975-m6lkrehi 3162 11 during during IN cord-335975-m6lkrehi 3162 12 NIV NIV NNP cord-335975-m6lkrehi 3162 13 is be VBZ cord-335975-m6lkrehi 3162 14 unknown unknown JJ cord-335975-m6lkrehi 3162 15 . . . cord-335975-m6lkrehi 3163 1 The the DT cord-335975-m6lkrehi 3163 2 aim aim NN cord-335975-m6lkrehi 3163 3 of of IN cord-335975-m6lkrehi 3163 4 this this DT cord-335975-m6lkrehi 3163 5 study study NN cord-335975-m6lkrehi 3163 6 was be VBD cord-335975-m6lkrehi 3163 7 to to TO cord-335975-m6lkrehi 3163 8 assess assess VB cord-335975-m6lkrehi 3163 9 two two CD cord-335975-m6lkrehi 3163 10 methods method NNS cord-335975-m6lkrehi 3163 11 of of IN cord-335975-m6lkrehi 3163 12 diaphragmatic diaphragmatic JJ cord-335975-m6lkrehi 3163 13 ultrasonography ultrasonography NN cord-335975-m6lkrehi 3163 14 ( ( -LRB- cord-335975-m6lkrehi 3163 15 excursion excursion NN cord-335975-m6lkrehi 3163 16 and and CC cord-335975-m6lkrehi 3163 17 thickening thickening NN cord-335975-m6lkrehi 3163 18 ) ) -RRB- cord-335975-m6lkrehi 3163 19 , , , cord-335975-m6lkrehi 3163 20 coupled couple VBN cord-335975-m6lkrehi 3163 21 with with IN cord-335975-m6lkrehi 3163 22 the the DT cord-335975-m6lkrehi 3163 23 airway airway NN cord-335975-m6lkrehi 3163 24 pressure pressure NN cord-335975-m6lkrehi 3163 25 signal signal NN cord-335975-m6lkrehi 3163 26 to to TO cord-335975-m6lkrehi 3163 27 detect detect VB cord-335975-m6lkrehi 3163 28 patient patient NN cord-335975-m6lkrehi 3163 29 - - HYPH cord-335975-m6lkrehi 3163 30 ventilator ventilator NN cord-335975-m6lkrehi 3163 31 asynchronies asynchrony NNS cord-335975-m6lkrehi 3163 32 during during IN cord-335975-m6lkrehi 3163 33 NIV NIV NNP cord-335975-m6lkrehi 3163 34 . . . cord-335975-m6lkrehi 3164 1 Patients patient NNS cord-335975-m6lkrehi 3164 2 and and CC cord-335975-m6lkrehi 3164 3 methods method NNS cord-335975-m6lkrehi 3164 4 : : : cord-335975-m6lkrehi 3164 5 Nine nine CD cord-335975-m6lkrehi 3164 6 healthy healthy JJ cord-335975-m6lkrehi 3164 7 subjects subject NNS cord-335975-m6lkrehi 3164 8 were be VBD cord-335975-m6lkrehi 3164 9 placed place VBN cord-335975-m6lkrehi 3164 10 under under IN cord-335975-m6lkrehi 3164 11 NIV NIV NNP cord-335975-m6lkrehi 3164 12 and and CC cord-335975-m6lkrehi 3164 13 subjected subject VBN cord-335975-m6lkrehi 3164 14 to to IN cord-335975-m6lkrehi 3164 15 intentional intentional JJ cord-335975-m6lkrehi 3164 16 inspiratory inspiratory JJ cord-335975-m6lkrehi 3164 17 and and CC cord-335975-m6lkrehi 3164 18 expiratory expiratory JJ cord-335975-m6lkrehi 3164 19 leakage leakage NN cord-335975-m6lkrehi 3164 20 on on IN cord-335975-m6lkrehi 3164 21 the the DT cord-335975-m6lkrehi 3164 22 ventilator ventilator NN cord-335975-m6lkrehi 3164 23 circuit circuit NN cord-335975-m6lkrehi 3164 24 to to TO cord-335975-m6lkrehi 3164 25 generate generate VB cord-335975-m6lkrehi 3164 26 delayed delay VBN cord-335975-m6lkrehi 3164 27 cycling cycling NN cord-335975-m6lkrehi 3164 28 and and CC cord-335975-m6lkrehi 3164 29 auto auto NN cord-335975-m6lkrehi 3164 30 - - HYPH cord-335975-m6lkrehi 3164 31 triggering trigger VBG cord-335975-m6lkrehi 3164 32 , , , cord-335975-m6lkrehi 3164 33 respectively respectively RB cord-335975-m6lkrehi 3164 34 . . . cord-335975-m6lkrehi 3165 1 The the DT cord-335975-m6lkrehi 3165 2 flow flow NN cord-335975-m6lkrehi 3165 3 , , , cord-335975-m6lkrehi 3165 4 airway airway NN cord-335975-m6lkrehi 3165 5 pressure pressure NN cord-335975-m6lkrehi 3165 6 and and CC cord-335975-m6lkrehi 3165 7 diaphragmatic diaphragmatic JJ cord-335975-m6lkrehi 3165 8 electromyogram electromyogram NNP cord-335975-m6lkrehi 3165 9 were be VBD cord-335975-m6lkrehi 3165 10 collected collect VBN cord-335975-m6lkrehi 3165 11 in in IN cord-335975-m6lkrehi 3165 12 order order NN cord-335975-m6lkrehi 3165 13 to to TO cord-335975-m6lkrehi 3165 14 identify identify VB cord-335975-m6lkrehi 3165 15 the the DT cord-335975-m6lkrehi 3165 16 asynchronies asynchrony NNS cord-335975-m6lkrehi 3165 17 generated generate VBN cord-335975-m6lkrehi 3165 18 by by IN cord-335975-m6lkrehi 3165 19 the the DT cord-335975-m6lkrehi 3165 20 leaks leak NNS cord-335975-m6lkrehi 3165 21 . . . cord-335975-m6lkrehi 3166 1 In in IN cord-335975-m6lkrehi 3166 2 the the DT cord-335975-m6lkrehi 3166 3 meantime meantime NN cord-335975-m6lkrehi 3166 4 , , , cord-335975-m6lkrehi 3166 5 an an DT cord-335975-m6lkrehi 3166 6 ultrasound ultrasound NN cord-335975-m6lkrehi 3166 7 recording recording NN cord-335975-m6lkrehi 3166 8 of of IN cord-335975-m6lkrehi 3166 9 the the DT cord-335975-m6lkrehi 3166 10 excursion excursion NN cord-335975-m6lkrehi 3166 11 of of IN cord-335975-m6lkrehi 3166 12 the the DT cord-335975-m6lkrehi 3166 13 right right JJ cord-335975-m6lkrehi 3166 14 diaphragm diaphragm NN cord-335975-m6lkrehi 3166 15 and and CC cord-335975-m6lkrehi 3166 16 of of IN cord-335975-m6lkrehi 3166 17 the the DT cord-335975-m6lkrehi 3166 18 thickening thickening NN cord-335975-m6lkrehi 3166 19 of of IN cord-335975-m6lkrehi 3166 20 the the DT cord-335975-m6lkrehi 3166 21 right right JJ cord-335975-m6lkrehi 3166 22 diaphragmatic diaphragmatic JJ cord-335975-m6lkrehi 3166 23 zone zone NN cord-335975-m6lkrehi 3166 24 of of IN cord-335975-m6lkrehi 3166 25 apposition apposition NN cord-335975-m6lkrehi 3166 26 were be VBD cord-335975-m6lkrehi 3166 27 performed perform VBN cord-335975-m6lkrehi 3166 28 and and CC cord-335975-m6lkrehi 3166 29 combined combine VBN cord-335975-m6lkrehi 3166 30 with with IN cord-335975-m6lkrehi 3166 31 the the DT cord-335975-m6lkrehi 3166 32 display display NN cord-335975-m6lkrehi 3166 33 of of IN cord-335975-m6lkrehi 3166 34 airway airway NN cord-335975-m6lkrehi 3166 35 pressure pressure NN cord-335975-m6lkrehi 3166 36 on on IN cord-335975-m6lkrehi 3166 37 the the DT cord-335975-m6lkrehi 3166 38 ultrasound ultrasound NN cord-335975-m6lkrehi 3166 39 screen screen NN cord-335975-m6lkrehi 3166 40 . . . cord-335975-m6lkrehi 3167 1 These these DT cord-335975-m6lkrehi 3167 2 records record NNS cord-335975-m6lkrehi 3167 3 were be VBD cord-335975-m6lkrehi 3167 4 analyzed analyze VBN cord-335975-m6lkrehi 3167 5 a a DT cord-335975-m6lkrehi 3167 6 posteriori posteriori NN cord-335975-m6lkrehi 3167 7 to to TO cord-335975-m6lkrehi 3167 8 define define VB cord-335975-m6lkrehi 3167 9 the the DT cord-335975-m6lkrehi 3167 10 diagnostic diagnostic JJ cord-335975-m6lkrehi 3167 11 performance performance NN cord-335975-m6lkrehi 3167 12 [ [ -LRB- cord-335975-m6lkrehi 3167 13 including include VBG cord-335975-m6lkrehi 3167 14 sensitivity sensitivity NN cord-335975-m6lkrehi 3167 15 ( ( -LRB- cord-335975-m6lkrehi 3167 16 Se Se NNP cord-335975-m6lkrehi 3167 17 ) ) -RRB- cord-335975-m6lkrehi 3167 18 , , , cord-335975-m6lkrehi 3167 19 specificity specificity NN cord-335975-m6lkrehi 3167 20 ( ( -LRB- cord-335975-m6lkrehi 3167 21 Spe Spe NNP cord-335975-m6lkrehi 3167 22 ) ) -RRB- cord-335975-m6lkrehi 3167 23 , , , cord-335975-m6lkrehi 3167 24 positive positive JJ cord-335975-m6lkrehi 3167 25 predictive predictive JJ cord-335975-m6lkrehi 3167 26 value value NN cord-335975-m6lkrehi 3167 27 ( ( -LRB- cord-335975-m6lkrehi 3167 28 Ppv Ppv NNP cord-335975-m6lkrehi 3167 29 ) ) -RRB- cord-335975-m6lkrehi 3167 30 , , , cord-335975-m6lkrehi 3167 31 and and CC cord-335975-m6lkrehi 3167 32 negative negative JJ cord-335975-m6lkrehi 3167 33 predictive predictive JJ cord-335975-m6lkrehi 3167 34 value value NN cord-335975-m6lkrehi 3167 35 ( ( -LRB- cord-335975-m6lkrehi 3167 36 Npv Npv NNP cord-335975-m6lkrehi 3167 37 ) ) -RRB- cord-335975-m6lkrehi 3167 38 ] ] -RRB- cord-335975-m6lkrehi 3167 39 of of IN cord-335975-m6lkrehi 3167 40 the the DT cord-335975-m6lkrehi 3167 41 excursion excursion NN cord-335975-m6lkrehi 3167 42 and and CC cord-335975-m6lkrehi 3167 43 the the DT cord-335975-m6lkrehi 3167 44 thickening thickening NN cord-335975-m6lkrehi 3167 45 to to TO cord-335975-m6lkrehi 3167 46 detect detect VB cord-335975-m6lkrehi 3167 47 asynchronies asynchrony NNS cord-335975-m6lkrehi 3167 48 . . . cord-335975-m6lkrehi 3168 1 The the DT cord-335975-m6lkrehi 3168 2 experimental experimental JJ cord-335975-m6lkrehi 3168 3 setup setup NN cord-335975-m6lkrehi 3168 4 generated generate VBD cord-335975-m6lkrehi 3168 5 a a DT cord-335975-m6lkrehi 3168 6 median median NN cord-335975-m6lkrehi 3168 7 of of IN cord-335975-m6lkrehi 3168 8 34 34 CD cord-335975-m6lkrehi 3168 9 asynchronies asynchrony NNS cord-335975-m6lkrehi 3168 10 per per IN cord-335975-m6lkrehi 3168 11 subject subject NN cord-335975-m6lkrehi 3168 12 ( ( -LRB- cord-335975-m6lkrehi 3168 13 interquartile interquartile JJ cord-335975-m6lkrehi 3168 14 range range VBP cord-335975-m6lkrehi 3168 15 24 24 CD cord-335975-m6lkrehi 3168 16 - - SYM cord-335975-m6lkrehi 3168 17 44 44 CD cord-335975-m6lkrehi 3168 18 ) ) -RRB- cord-335975-m6lkrehi 3168 19 . . . cord-335975-m6lkrehi 3169 1 Auto auto NN cord-335975-m6lkrehi 3169 2 - - HYPH cord-335975-m6lkrehi 3169 3 triggering triggering NN cord-335975-m6lkrehi 3169 4 was be VBD cord-335975-m6lkrehi 3169 5 correctly correctly RB cord-335975-m6lkrehi 3169 6 identified identify VBN cord-335975-m6lkrehi 3169 7 by by IN cord-335975-m6lkrehi 3169 8 continuous continuous JJ cord-335975-m6lkrehi 3169 9 recording recording NN cord-335975-m6lkrehi 3169 10 of of IN cord-335975-m6lkrehi 3169 11 both both DT cord-335975-m6lkrehi 3169 12 excursion excursion NN cord-335975-m6lkrehi 3169 13 ( ( -LRB- cord-335975-m6lkrehi 3169 14 Se Se NNP cord-335975-m6lkrehi 3169 15 = = SYM cord-335975-m6lkrehi 3169 16 93 93 CD cord-335975-m6lkrehi 3169 17 % % NN cord-335975-m6lkrehi 3169 18 , , , cord-335975-m6lkrehi 3169 19 Spe Spe NNP cord-335975-m6lkrehi 3169 20 = = SYM cord-335975-m6lkrehi 3169 21 99 99 CD cord-335975-m6lkrehi 3169 22 % % NN cord-335975-m6lkrehi 3169 23 , , , cord-335975-m6lkrehi 3169 24 Ppv Ppv NNP cord-335975-m6lkrehi 3169 25 = = SYM cord-335975-m6lkrehi 3169 26 93 93 CD cord-335975-m6lkrehi 3169 27 % % NN cord-335975-m6lkrehi 3169 28 , , , cord-335975-m6lkrehi 3169 29 and and CC cord-335975-m6lkrehi 3169 30 Npv Npv NNP cord-335975-m6lkrehi 3169 31 = = SYM cord-335975-m6lkrehi 3169 32 99 99 CD cord-335975-m6lkrehi 3169 33 % % NN cord-335975-m6lkrehi 3169 34 , , , cord-335975-m6lkrehi 3169 35 Fig Fig NNP cord-335975-m6lkrehi 3169 36 . . . cord-335975-m6lkrehi 3169 37 1A 1a NN cord-335975-m6lkrehi 3169 38 ) ) -RRB- cord-335975-m6lkrehi 3169 39 and and CC cord-335975-m6lkrehi 3169 40 thickening thickening NN cord-335975-m6lkrehi 3169 41 ( ( -LRB- cord-335975-m6lkrehi 3169 42 Se Se NNP cord-335975-m6lkrehi 3169 43 = = SYM cord-335975-m6lkrehi 3169 44 94 94 CD cord-335975-m6lkrehi 3169 45 % % NN cord-335975-m6lkrehi 3169 46 , , , cord-335975-m6lkrehi 3169 47 Spe Spe NNP cord-335975-m6lkrehi 3169 48 = = SYM cord-335975-m6lkrehi 3169 49 99 99 CD cord-335975-m6lkrehi 3169 50 % % NN cord-335975-m6lkrehi 3169 51 , , , cord-335975-m6lkrehi 3169 52 Ppv Ppv NNP cord-335975-m6lkrehi 3169 53 = = SYM cord-335975-m6lkrehi 3169 54 95 95 CD cord-335975-m6lkrehi 3169 55 % % NN cord-335975-m6lkrehi 3169 56 , , , cord-335975-m6lkrehi 3169 57 Npv Npv NNP cord-335975-m6lkrehi 3169 58 = = SYM cord-335975-m6lkrehi 3169 59 99 99 CD cord-335975-m6lkrehi 3169 60 % % NN cord-335975-m6lkrehi 3170 1 + + CC cord-335975-m6lkrehi 3171 1 Fig Fig NNP cord-335975-m6lkrehi 3171 2 . . . cord-335975-m6lkrehi 3171 3 1C 1C NNP cord-335975-m6lkrehi 3171 4 ) ) -RRB- cord-335975-m6lkrehi 3171 5 . . . cord-335975-m6lkrehi 3172 1 Delayed delayed JJ cord-335975-m6lkrehi 3172 2 cycling cycling NN cord-335975-m6lkrehi 3172 3 was be VBD cord-335975-m6lkrehi 3172 4 detected detect VBN cord-335975-m6lkrehi 3172 5 with with IN cord-335975-m6lkrehi 3172 6 a a DT cord-335975-m6lkrehi 3172 7 slightly slightly RB cord-335975-m6lkrehi 3172 8 lower low JJR cord-335975-m6lkrehi 3172 9 performance performance NN cord-335975-m6lkrehi 3172 10 by by IN cord-335975-m6lkrehi 3172 11 diaphragm diaphragm NN cord-335975-m6lkrehi 3172 12 excursion excursion NN cord-335975-m6lkrehi 3173 1 ( ( -LRB- cord-335975-m6lkrehi 3173 2 Se Se NNP cord-335975-m6lkrehi 3173 3 = = SYM cord-335975-m6lkrehi 3173 4 85 85 CD cord-335975-m6lkrehi 3173 5 % % NN cord-335975-m6lkrehi 3173 6 , , , cord-335975-m6lkrehi 3173 7 Spe Spe NNP cord-335975-m6lkrehi 3173 8 = = SYM cord-335975-m6lkrehi 3173 9 98 98 CD cord-335975-m6lkrehi 3173 10 % % NN cord-335975-m6lkrehi 3173 11 , , , cord-335975-m6lkrehi 3173 12 Ppv Ppv NNP cord-335975-m6lkrehi 3173 13 = = SYM cord-335975-m6lkrehi 3173 14 84 84 CD cord-335975-m6lkrehi 3173 15 % % NN cord-335975-m6lkrehi 3173 16 , , , cord-335975-m6lkrehi 3173 17 Npv Npv NNP cord-335975-m6lkrehi 3173 18 = = SYM cord-335975-m6lkrehi 3173 19 98 98 CD cord-335975-m6lkrehi 3173 20 % % NN cord-335975-m6lkrehi 3173 21 + + CC cord-335975-m6lkrehi 3173 22 Fig fig NN cord-335975-m6lkrehi 3173 23 . . . cord-335975-m6lkrehi 3173 24 1B 1b CD cord-335975-m6lkrehi 3173 25 ) ) -RRB- cord-335975-m6lkrehi 3173 26 and and CC cord-335975-m6lkrehi 3173 27 thickening thickening NN cord-335975-m6lkrehi 3173 28 ( ( -LRB- cord-335975-m6lkrehi 3173 29 Se Se NNP cord-335975-m6lkrehi 3173 30 = = SYM cord-335975-m6lkrehi 3173 31 89 89 CD cord-335975-m6lkrehi 3173 32 % % NN cord-335975-m6lkrehi 3173 33 , , , cord-335975-m6lkrehi 3173 34 Spe Spe NNP cord-335975-m6lkrehi 3173 35 = = SYM cord-335975-m6lkrehi 3173 36 98 98 CD cord-335975-m6lkrehi 3173 37 % % NN cord-335975-m6lkrehi 3173 38 , , , cord-335975-m6lkrehi 3173 39 Ppv Ppv NNP cord-335975-m6lkrehi 3173 40 = = SYM cord-335975-m6lkrehi 3173 41 86 86 CD cord-335975-m6lkrehi 3173 42 % % NN cord-335975-m6lkrehi 3173 43 , , , cord-335975-m6lkrehi 3173 44 Npv Npv NNP cord-335975-m6lkrehi 3173 45 = = NFP cord-335975-m6lkrehi 3174 1 99 99 CD cord-335975-m6lkrehi 3174 2 % % NN cord-335975-m6lkrehi 3175 1 + + CC cord-335975-m6lkrehi 3175 2 Fig Fig NNP cord-335975-m6lkrehi 3175 3 _SP cord-335975-m6lkrehi 3175 4 D D NNP cord-335975-m6lkrehi 3175 5 ) ) -RRB- cord-335975-m6lkrehi 3175 6 . . . cord-335975-m6lkrehi 3176 1 Discussion discussion NN cord-335975-m6lkrehi 3176 2 : : : cord-335975-m6lkrehi 3177 1 These these DT cord-335975-m6lkrehi 3177 2 encouraging encouraging JJ cord-335975-m6lkrehi 3177 3 results result NNS cord-335975-m6lkrehi 3177 4 may may MD cord-335975-m6lkrehi 3177 5 be be VB cord-335975-m6lkrehi 3177 6 tempered temper VBN cord-335975-m6lkrehi 3177 7 by by IN cord-335975-m6lkrehi 3177 8 a a DT cord-335975-m6lkrehi 3177 9 variable variable JJ cord-335975-m6lkrehi 3177 10 effectiveness effectiveness NN cord-335975-m6lkrehi 3177 11 of of IN cord-335975-m6lkrehi 3177 12 the the DT cord-335975-m6lkrehi 3177 13 technique technique NN cord-335975-m6lkrehi 3177 14 from from IN cord-335975-m6lkrehi 3177 15 one one CD cord-335975-m6lkrehi 3177 16 subject subject NN cord-335975-m6lkrehi 3177 17 to to IN cord-335975-m6lkrehi 3177 18 another another DT cord-335975-m6lkrehi 3177 19 , , , cord-335975-m6lkrehi 3177 20 in in IN cord-335975-m6lkrehi 3177 21 particular particular JJ cord-335975-m6lkrehi 3177 22 concerning concern VBG cord-335975-m6lkrehi 3177 23 the the DT cord-335975-m6lkrehi 3177 24 excursion excursion NN cord-335975-m6lkrehi 3177 25 . . . cord-335975-m6lkrehi 3178 1 Moreover moreover RB cord-335975-m6lkrehi 3178 2 , , , cord-335975-m6lkrehi 3178 3 their -PRON- PRP$ cord-335975-m6lkrehi 3178 4 generalization generalization NN cord-335975-m6lkrehi 3178 5 to to IN cord-335975-m6lkrehi 3178 6 critically critically RB cord-335975-m6lkrehi 3178 7 ill ill JJ cord-335975-m6lkrehi 3178 8 patients patient NNS cord-335975-m6lkrehi 3178 9 may may MD cord-335975-m6lkrehi 3178 10 depend depend VB cord-335975-m6lkrehi 3178 11 on on IN cord-335975-m6lkrehi 3178 12 several several JJ cord-335975-m6lkrehi 3178 13 factors factor NNS cord-335975-m6lkrehi 3178 14 including include VBG cord-335975-m6lkrehi 3178 15 echogenicity echogenicity NN cord-335975-m6lkrehi 3178 16 , , , cord-335975-m6lkrehi 3178 17 stability stability NN cord-335975-m6lkrehi 3178 18 and and CC cord-335975-m6lkrehi 3178 19 amplitude amplitude NN cord-335975-m6lkrehi 3178 20 of of IN cord-335975-m6lkrehi 3178 21 the the DT cord-335975-m6lkrehi 3178 22 ultrasound ultrasound NN cord-335975-m6lkrehi 3178 23 signal signal NN cord-335975-m6lkrehi 3178 24 in in IN cord-335975-m6lkrehi 3178 25 this this DT cord-335975-m6lkrehi 3178 26 population population NN cord-335975-m6lkrehi 3178 27 . . . cord-335975-m6lkrehi 3179 1 Conclusion conclusion NN cord-335975-m6lkrehi 3179 2 : : : cord-335975-m6lkrehi 3179 3 Ultrasound ultrasound NN cord-335975-m6lkrehi 3179 4 is be VBZ cord-335975-m6lkrehi 3179 5 a a DT cord-335975-m6lkrehi 3179 6 simple simple JJ cord-335975-m6lkrehi 3179 7 clinical clinical JJ cord-335975-m6lkrehi 3179 8 tool tool NN cord-335975-m6lkrehi 3179 9 available available JJ cord-335975-m6lkrehi 3179 10 at at IN cord-335975-m6lkrehi 3179 11 the the DT cord-335975-m6lkrehi 3179 12 bedside bedside NN cord-335975-m6lkrehi 3179 13 to to TO cord-335975-m6lkrehi 3179 14 detect detect VB cord-335975-m6lkrehi 3179 15 delayed delay VBN cord-335975-m6lkrehi 3179 16 cycling cycling NN cord-335975-m6lkrehi 3179 17 and and CC cord-335975-m6lkrehi 3179 18 auto auto NN cord-335975-m6lkrehi 3179 19 - - HYPH cord-335975-m6lkrehi 3179 20 triggering trigger VBG cord-335975-m6lkrehi 3179 21 associated associate VBN cord-335975-m6lkrehi 3179 22 with with IN cord-335975-m6lkrehi 3179 23 NIV NIV NNP cord-335975-m6lkrehi 3179 24 leaks leak NNS cord-335975-m6lkrehi 3179 25 , , , cord-335975-m6lkrehi 3179 26 provided provide VBN cord-335975-m6lkrehi 3179 27 that that IN cord-335975-m6lkrehi 3179 28 the the DT cord-335975-m6lkrehi 3179 29 airway airway NN cord-335975-m6lkrehi 3179 30 pressure pressure NN cord-335975-m6lkrehi 3179 31 curve curve NN cord-335975-m6lkrehi 3179 32 is be VBZ cord-335975-m6lkrehi 3179 33 displayed display VBN cord-335975-m6lkrehi 3179 34 on on IN cord-335975-m6lkrehi 3179 35 the the DT cord-335975-m6lkrehi 3179 36 screen screen NN cord-335975-m6lkrehi 3179 37 of of IN cord-335975-m6lkrehi 3179 38 the the DT cord-335975-m6lkrehi 3179 39 ultrasound ultrasound NN cord-335975-m6lkrehi 3179 40 machine machine NN cord-335975-m6lkrehi 3179 41 . . . cord-335975-m6lkrehi 3180 1 Further further JJ cord-335975-m6lkrehi 3180 2 studies study NNS cord-335975-m6lkrehi 3180 3 are be VBP cord-335975-m6lkrehi 3180 4 needed need VBN cord-335975-m6lkrehi 3180 5 to to TO cord-335975-m6lkrehi 3180 6 assess assess VB cord-335975-m6lkrehi 3180 7 its -PRON- PRP$ cord-335975-m6lkrehi 3180 8 usefulness usefulness NN cord-335975-m6lkrehi 3180 9 in in IN cord-335975-m6lkrehi 3180 10 detecting detect VBG cord-335975-m6lkrehi 3180 11 other other JJ cord-335975-m6lkrehi 3180 12 types type NNS cord-335975-m6lkrehi 3180 13 of of IN cord-335975-m6lkrehi 3180 14 asynchronies asynchrony NNS cord-335975-m6lkrehi 3180 15 and and CC cord-335975-m6lkrehi 3180 16 its -PRON- PRP$ cord-335975-m6lkrehi 3180 17 feasibility feasibility NN cord-335975-m6lkrehi 3180 18 in in IN cord-335975-m6lkrehi 3180 19 critically critically RB cord-335975-m6lkrehi 3180 20 - - HYPH cord-335975-m6lkrehi 3180 21 ill ill JJ cord-335975-m6lkrehi 3180 22 patients patient NNS cord-335975-m6lkrehi 3180 23 . . . cord-335975-m6lkrehi 3181 1 Introduction introduction NN cord-335975-m6lkrehi 3181 2 : : : cord-335975-m6lkrehi 3182 1 Although although IN cord-335975-m6lkrehi 3182 2 extra extra JJ cord-335975-m6lkrehi 3182 3 - - JJ cord-335975-m6lkrehi 3182 4 corporeal corporeal JJ cord-335975-m6lkrehi 3182 5 CO2 co2 NN cord-335975-m6lkrehi 3182 6 removal removal NN cord-335975-m6lkrehi 3182 7 ( ( -LRB- cord-335975-m6lkrehi 3182 8 ECCO2R ECCO2R NNP cord-335975-m6lkrehi 3182 9 ) ) -RRB- cord-335975-m6lkrehi 3182 10 is be VBZ cord-335975-m6lkrehi 3182 11 not not RB cord-335975-m6lkrehi 3182 12 recommended recommend VBN cord-335975-m6lkrehi 3182 13 , , , cord-335975-m6lkrehi 3182 14 strong strong JJ cord-335975-m6lkrehi 3182 15 rational rational JJ cord-335975-m6lkrehi 3182 16 supports support VBZ cord-335975-m6lkrehi 3182 17 the the DT cord-335975-m6lkrehi 3182 18 concept concept NN cord-335975-m6lkrehi 3182 19 . . . cord-335975-m6lkrehi 3183 1 We -PRON- PRP cord-335975-m6lkrehi 3183 2 aimed aim VBD cord-335975-m6lkrehi 3183 3 to to TO cord-335975-m6lkrehi 3183 4 describe describe VB cord-335975-m6lkrehi 3183 5 our -PRON- PRP$ cord-335975-m6lkrehi 3183 6 single single JJ cord-335975-m6lkrehi 3183 7 - - HYPH cord-335975-m6lkrehi 3183 8 center center NN cord-335975-m6lkrehi 3183 9 experience experience NN cord-335975-m6lkrehi 3183 10 of of IN cord-335975-m6lkrehi 3183 11 ECCO2R ecco2r NN cord-335975-m6lkrehi 3183 12 in in IN cord-335975-m6lkrehi 3183 13 the the DT cord-335975-m6lkrehi 3183 14 setting setting NN cord-335975-m6lkrehi 3183 15 of of IN cord-335975-m6lkrehi 3183 16 mild mild JJ cord-335975-m6lkrehi 3183 17 to to TO cord-335975-m6lkrehi 3183 18 moderate moderate VB cord-335975-m6lkrehi 3183 19 acute acute JJ cord-335975-m6lkrehi 3183 20 respiratory respiratory JJ cord-335975-m6lkrehi 3183 21 distress distress NN cord-335975-m6lkrehi 3183 22 syndrome syndrome NN cord-335975-m6lkrehi 3183 23 ( ( -LRB- cord-335975-m6lkrehi 3183 24 ARDS ARDS NNP cord-335975-m6lkrehi 3183 25 ) ) -RRB- cord-335975-m6lkrehi 3183 26 and and CC cord-335975-m6lkrehi 3183 27 chronic chronic JJ cord-335975-m6lkrehi 3183 28 obstructive obstructive JJ cord-335975-m6lkrehi 3183 29 pulmonary pulmonary JJ cord-335975-m6lkrehi 3183 30 disease disease NN cord-335975-m6lkrehi 3183 31 ( ( -LRB- cord-335975-m6lkrehi 3183 32 COPD COPD NNP cord-335975-m6lkrehi 3183 33 ) ) -RRB- cord-335975-m6lkrehi 3183 34 . . . cord-335975-m6lkrehi 3184 1 We -PRON- PRP cord-335975-m6lkrehi 3184 2 performed perform VBD cord-335975-m6lkrehi 3184 3 a a DT cord-335975-m6lkrehi 3184 4 retrospective retrospective JJ cord-335975-m6lkrehi 3184 5 case case NN cord-335975-m6lkrehi 3184 6 note note NN cord-335975-m6lkrehi 3184 7 review review NN cord-335975-m6lkrehi 3184 8 of of IN cord-335975-m6lkrehi 3184 9 patients patient NNS cord-335975-m6lkrehi 3184 10 admitted admit VBN cord-335975-m6lkrehi 3184 11 to to IN cord-335975-m6lkrehi 3184 12 our -PRON- PRP$ cord-335975-m6lkrehi 3184 13 tertiary tertiary JJ cord-335975-m6lkrehi 3184 14 regional regional JJ cord-335975-m6lkrehi 3184 15 intensive intensive JJ cord-335975-m6lkrehi 3184 16 care care NN cord-335975-m6lkrehi 3184 17 unit unit NN cord-335975-m6lkrehi 3184 18 ( ( -LRB- cord-335975-m6lkrehi 3184 19 ICU ICU NNP cord-335975-m6lkrehi 3184 20 ) ) -RRB- cord-335975-m6lkrehi 3184 21 and and CC cord-335975-m6lkrehi 3184 22 commenced commence VBD cord-335975-m6lkrehi 3184 23 on on IN cord-335975-m6lkrehi 3184 24 ECCO2R ECCO2R NNP cord-335975-m6lkrehi 3184 25 from from IN cord-335975-m6lkrehi 3184 26 November November NNP cord-335975-m6lkrehi 3184 27 2015 2015 CD cord-335975-m6lkrehi 3184 28 to to IN cord-335975-m6lkrehi 3184 29 August August NNP cord-335975-m6lkrehi 3184 30 2017 2017 CD cord-335975-m6lkrehi 3184 31 . . . cord-335975-m6lkrehi 3185 1 Demographic demographic JJ cord-335975-m6lkrehi 3185 2 data datum NNS cord-335975-m6lkrehi 3185 3 , , , cord-335975-m6lkrehi 3185 4 physiologic physiologic JJ cord-335975-m6lkrehi 3185 5 data datum NNS cord-335975-m6lkrehi 3185 6 ( ( -LRB- cord-335975-m6lkrehi 3185 7 including include VBG cord-335975-m6lkrehi 3185 8 pH ph NN cord-335975-m6lkrehi 3185 9 and and CC cord-335975-m6lkrehi 3185 10 partial partial JJ cord-335975-m6lkrehi 3185 11 pressure pressure NN cord-335975-m6lkrehi 3185 12 of of IN cord-335975-m6lkrehi 3185 13 carbon carbon NN cord-335975-m6lkrehi 3185 14 dioxide dioxide NN cord-335975-m6lkrehi 3185 15 in in IN cord-335975-m6lkrehi 3185 16 arterial arterial JJ cord-335975-m6lkrehi 3185 17 blood blood NN cord-335975-m6lkrehi 3185 18 [ [ -LRB- cord-335975-m6lkrehi 3185 19 PaCO2 paco2 NN cord-335975-m6lkrehi 3185 20 ] ] -RRB- cord-335975-m6lkrehi 3185 21 ) ) -RRB- cord-335975-m6lkrehi 3185 22 before before IN cord-335975-m6lkrehi 3185 23 ECCO2R ECCO2R NNP cord-335975-m6lkrehi 3185 24 starting start VBG cord-335975-m6lkrehi 3185 25 , , , cord-335975-m6lkrehi 3185 26 and and CC cord-335975-m6lkrehi 3185 27 at at IN cord-335975-m6lkrehi 3185 28 day day NN cord-335975-m6lkrehi 3185 29 1 1 CD cord-335975-m6lkrehi 3185 30 were be VBD cord-335975-m6lkrehi 3185 31 recorded record VBN cord-335975-m6lkrehi 3185 32 . . . cord-335975-m6lkrehi 3186 1 Results result NNS cord-335975-m6lkrehi 3186 2 : : : cord-335975-m6lkrehi 3187 1 Twenty twenty CD cord-335975-m6lkrehi 3187 2 one one CD cord-335975-m6lkrehi 3187 3 patients patient NNS cord-335975-m6lkrehi 3187 4 received receive VBD cord-335975-m6lkrehi 3187 5 ECCO2R. ecco2r. IN cord-335975-m6lkrehi 3187 6 Thirteen Thirteen NNP cord-335975-m6lkrehi 3187 7 were be VBD cord-335975-m6lkrehi 3187 8 managed manage VBN cord-335975-m6lkrehi 3187 9 with with IN cord-335975-m6lkrehi 3187 10 Hemolung Hemolung NNP cord-335975-m6lkrehi 3187 11 ® ® POS cord-335975-m6lkrehi 3187 12 device device NN cord-335975-m6lkrehi 3187 13 , , , cord-335975-m6lkrehi 3187 14 seven seven CD cord-335975-m6lkrehi 3187 15 with with IN cord-335975-m6lkrehi 3187 16 Prismalung Prismalung NNP cord-335975-m6lkrehi 3187 17 ® ® . cord-335975-m6lkrehi 3187 18 and and CC cord-335975-m6lkrehi 3187 19 one one CD cord-335975-m6lkrehi 3187 20 with with IN cord-335975-m6lkrehi 3187 21 ILA ILA NNP cord-335975-m6lkrehi 3187 22 ® ® NNP cord-335975-m6lkrehi 3187 23 . . . cord-335975-m6lkrehi 3188 1 Indication indication NN cord-335975-m6lkrehi 3188 2 for for IN cord-335975-m6lkrehi 3188 3 ECCO2R ECCO2R NNP cord-335975-m6lkrehi 3188 4 were be VBD cord-335975-m6lkrehi 3188 5 COPD COPD NNP cord-335975-m6lkrehi 3188 6 exacerbation exacerbation NN cord-335975-m6lkrehi 3188 7 ( ( -LRB- cord-335975-m6lkrehi 3188 8 n n NN cord-335975-m6lkrehi 3188 9 = = SYM cord-335975-m6lkrehi 3188 10 11 11 CD cord-335975-m6lkrehi 3188 11 ) ) -RRB- cord-335975-m6lkrehi 3188 12 , , , cord-335975-m6lkrehi 3188 13 mild mild JJ cord-335975-m6lkrehi 3188 14 to to IN cord-335975-m6lkrehi 3188 15 moderate moderate JJ cord-335975-m6lkrehi 3188 16 ARDS ARDS NNP cord-335975-m6lkrehi 3188 17 ( ( -LRB- cord-335975-m6lkrehi 3188 18 n n NN cord-335975-m6lkrehi 3188 19 = = SYM cord-335975-m6lkrehi 3188 20 8) 8) NN cord-335975-m6lkrehi 3188 21 , , , cord-335975-m6lkrehi 3188 22 uncontrolled uncontrolled JJ cord-335975-m6lkrehi 3188 23 hypercapnia hypercapnia NN cord-335975-m6lkrehi 3188 24 due due IN cord-335975-m6lkrehi 3188 25 to to IN cord-335975-m6lkrehi 3188 26 pneumonia pneumonia NN cord-335975-m6lkrehi 3189 1 ( ( -LRB- cord-335975-m6lkrehi 3189 2 n n NN cord-335975-m6lkrehi 3189 3 = = SYM cord-335975-m6lkrehi 3189 4 1 1 CD cord-335975-m6lkrehi 3189 5 ) ) -RRB- cord-335975-m6lkrehi 3189 6 , , , cord-335975-m6lkrehi 3189 7 and and CC cord-335975-m6lkrehi 3189 8 hypercapnia hypercapnia NN cord-335975-m6lkrehi 3189 9 due due IN cord-335975-m6lkrehi 3189 10 to to IN cord-335975-m6lkrehi 3189 11 bronchial bronchial JJ cord-335975-m6lkrehi 3189 12 compression compression NN cord-335975-m6lkrehi 3189 13 by by IN cord-335975-m6lkrehi 3189 14 mediastinal mediastinal JJ cord-335975-m6lkrehi 3189 15 adenopathy adenopathy NNP cord-335975-m6lkrehi 3189 16 ( ( -LRB- cord-335975-m6lkrehi 3189 17 n n NN cord-335975-m6lkrehi 3189 18 = = SYM cord-335975-m6lkrehi 3189 19 1 1 CD cord-335975-m6lkrehi 3189 20 ) ) -RRB- cord-335975-m6lkrehi 3189 21 . . . cord-335975-m6lkrehi 3190 1 Before before IN cord-335975-m6lkrehi 3190 2 starting start VBG cord-335975-m6lkrehi 3190 3 ECCO2R ecco2r NN cord-335975-m6lkrehi 3190 4 , , , cord-335975-m6lkrehi 3190 5 median median JJ cord-335975-m6lkrehi 3190 6 minute minute NN cord-335975-m6lkrehi 3190 7 ventilation ventilation NN cord-335975-m6lkrehi 3190 8 , , , cord-335975-m6lkrehi 3190 9 pH pH NNP cord-335975-m6lkrehi 3190 10 and and CC cord-335975-m6lkrehi 3190 11 PaCO2 PaCO2 NNP cord-335975-m6lkrehi 3190 12 were be VBD cord-335975-m6lkrehi 3190 13 respectively respectively RB cord-335975-m6lkrehi 3190 14 7 7 CD cord-335975-m6lkrehi 3190 15 . . . cord-335975-m6lkrehi 3191 1 2 2 LS cord-335975-m6lkrehi 3191 2 [ [ -LRB- cord-335975-m6lkrehi 3191 3 6.5 6.5 CD cord-335975-m6lkrehi 3191 4 , , , cord-335975-m6lkrehi 3191 5 8.5 8.5 CD cord-335975-m6lkrehi 3191 6 Conclusion conclusion NN cord-335975-m6lkrehi 3191 7 : : : cord-335975-m6lkrehi 3192 1 Our -PRON- PRP$ cord-335975-m6lkrehi 3192 2 observational observational JJ cord-335975-m6lkrehi 3192 3 cohort cohort NN cord-335975-m6lkrehi 3192 4 shows show VBZ cord-335975-m6lkrehi 3192 5 that that IN cord-335975-m6lkrehi 3192 6 ECCO2R ECCO2R NNP cord-335975-m6lkrehi 3192 7 therapy therapy NN cord-335975-m6lkrehi 3192 8 is be VBZ cord-335975-m6lkrehi 3192 9 effective effective JJ cord-335975-m6lkrehi 3192 10 to to TO cord-335975-m6lkrehi 3192 11 reduce reduce VB cord-335975-m6lkrehi 3192 12 PaCO2 paco2 CD cord-335975-m6lkrehi 3192 13 and and CC cord-335975-m6lkrehi 3192 14 improve improve VB cord-335975-m6lkrehi 3192 15 pH ph NN cord-335975-m6lkrehi 3192 16 in in IN cord-335975-m6lkrehi 3192 17 the the DT cord-335975-m6lkrehi 3192 18 settings setting NNS cord-335975-m6lkrehi 3192 19 of of IN cord-335975-m6lkrehi 3192 20 mild mild JJ cord-335975-m6lkrehi 3192 21 ARDS ARDS NNP cord-335975-m6lkrehi 3192 22 and and CC cord-335975-m6lkrehi 3192 23 COPD COPD NNP cord-335975-m6lkrehi 3192 24 exacerbation exacerbation NN cord-335975-m6lkrehi 3192 25 . . . cord-335975-m6lkrehi 3193 1 However however RB cord-335975-m6lkrehi 3193 2 , , , cord-335975-m6lkrehi 3193 3 early early JJ cord-335975-m6lkrehi 3193 4 weaning weaning NN cord-335975-m6lkrehi 3193 5 of of IN cord-335975-m6lkrehi 3193 6 sedation sedation NN cord-335975-m6lkrehi 3193 7 and and CC cord-335975-m6lkrehi 3193 8 pressure pressure NN cord-335975-m6lkrehi 3193 9 support support NN cord-335975-m6lkrehi 3193 10 ventilation ventilation NN cord-335975-m6lkrehi 3193 11 might may MD cord-335975-m6lkrehi 3193 12 limit limit VB cord-335975-m6lkrehi 3193 13 the the DT cord-335975-m6lkrehi 3193 14 decrease decrease NN cord-335975-m6lkrehi 3193 15 of of IN cord-335975-m6lkrehi 3193 16 respiratory respiratory JJ cord-335975-m6lkrehi 3193 17 rate rate NN cord-335975-m6lkrehi 3193 18 and and CC cord-335975-m6lkrehi 3193 19 tidal tidal JJ cord-335975-m6lkrehi 3193 20 volume volume NN cord-335975-m6lkrehi 3193 21 . . . cord-335975-m6lkrehi 3194 1 Introduction introduction NN cord-335975-m6lkrehi 3194 2 : : : cord-335975-m6lkrehi 3194 3 Duchenne Duchenne NNP cord-335975-m6lkrehi 3194 4 muscular muscular JJ cord-335975-m6lkrehi 3194 5 dystrophy dystrophy NN cord-335975-m6lkrehi 3194 6 ( ( -LRB- cord-335975-m6lkrehi 3194 7 DMD DMD NNP cord-335975-m6lkrehi 3194 8 ) ) -RRB- cord-335975-m6lkrehi 3194 9 is be VBZ cord-335975-m6lkrehi 3194 10 an an DT cord-335975-m6lkrehi 3194 11 X x NN cord-335975-m6lkrehi 3194 12 - - HYPH cord-335975-m6lkrehi 3194 13 linked link VBN cord-335975-m6lkrehi 3194 14 recessive recessive JJ cord-335975-m6lkrehi 3194 15 genetic genetic JJ cord-335975-m6lkrehi 3194 16 disorder disorder NN cord-335975-m6lkrehi 3194 17 , , , cord-335975-m6lkrehi 3194 18 caused cause VBN cord-335975-m6lkrehi 3194 19 by by IN cord-335975-m6lkrehi 3194 20 mutations mutation NNS cord-335975-m6lkrehi 3194 21 in in IN cord-335975-m6lkrehi 3194 22 the the DT cord-335975-m6lkrehi 3194 23 DMD DMD NNP cord-335975-m6lkrehi 3194 24 gene gene NN cord-335975-m6lkrehi 3194 25 . . . cord-335975-m6lkrehi 3195 1 Respiratory respiratory JJ cord-335975-m6lkrehi 3195 2 failure failure NN cord-335975-m6lkrehi 3195 3 is be VBZ cord-335975-m6lkrehi 3195 4 classical classical JJ cord-335975-m6lkrehi 3195 5 in in IN cord-335975-m6lkrehi 3195 6 the the DT cord-335975-m6lkrehi 3195 7 natural natural JJ cord-335975-m6lkrehi 3195 8 history history NN cord-335975-m6lkrehi 3195 9 of of IN cord-335975-m6lkrehi 3195 10 this this DT cord-335975-m6lkrehi 3195 11 disease disease NN cord-335975-m6lkrehi 3195 12 . . . cord-335975-m6lkrehi 3196 1 Little little JJ cord-335975-m6lkrehi 3196 2 is be VBZ cord-335975-m6lkrehi 3196 3 known know VBN cord-335975-m6lkrehi 3196 4 about about IN cord-335975-m6lkrehi 3196 5 the the DT cord-335975-m6lkrehi 3196 6 diaphragm diaphragm JJ cord-335975-m6lkrehi 3196 7 echographic echographic JJ cord-335975-m6lkrehi 3196 8 pattern pattern NN cord-335975-m6lkrehi 3196 9 and and CC cord-335975-m6lkrehi 3196 10 the the DT cord-335975-m6lkrehi 3196 11 spectrum spectrum NN cord-335975-m6lkrehi 3196 12 of of IN cord-335975-m6lkrehi 3196 13 patients patient NNS cord-335975-m6lkrehi 3196 14 with with IN cord-335975-m6lkrehi 3196 15 diaphragmatic diaphragmatic JJ cord-335975-m6lkrehi 3196 16 paralysis paralysis NN cord-335975-m6lkrehi 3196 17 in in IN cord-335975-m6lkrehi 3196 18 this this DT cord-335975-m6lkrehi 3196 19 disease disease NN cord-335975-m6lkrehi 3196 20 . . . cord-335975-m6lkrehi 3197 1 We -PRON- PRP cord-335975-m6lkrehi 3197 2 aimed aim VBD cord-335975-m6lkrehi 3197 3 to to TO cord-335975-m6lkrehi 3197 4 assess assess VB cord-335975-m6lkrehi 3197 5 the the DT cord-335975-m6lkrehi 3197 6 relationship relationship NN cord-335975-m6lkrehi 3197 7 between between IN cord-335975-m6lkrehi 3197 8 age age NN cord-335975-m6lkrehi 3197 9 and and CC cord-335975-m6lkrehi 3197 10 diaphragmatic diaphragmatic JJ cord-335975-m6lkrehi 3197 11 motion motion NN cord-335975-m6lkrehi 3197 12 and and CC cord-335975-m6lkrehi 3197 13 thickening thickening NN cord-335975-m6lkrehi 3197 14 fraction fraction NN cord-335975-m6lkrehi 3197 15 ( ( -LRB- cord-335975-m6lkrehi 3197 16 TF TF NNP cord-335975-m6lkrehi 3197 17 ) ) -RRB- cord-335975-m6lkrehi 3197 18 and and CC cord-335975-m6lkrehi 3197 19 to to TO cord-335975-m6lkrehi 3197 20 characterize characterize VB cord-335975-m6lkrehi 3197 21 the the DT cord-335975-m6lkrehi 3197 22 spectrum spectrum NN cord-335975-m6lkrehi 3197 23 of of IN cord-335975-m6lkrehi 3197 24 patients patient NNS cord-335975-m6lkrehi 3197 25 with with IN cord-335975-m6lkrehi 3197 26 diaphragmatic diaphragmatic JJ cord-335975-m6lkrehi 3197 27 paralysis paralysis NN cord-335975-m6lkrehi 3197 28 . . . cord-335975-m6lkrehi 3198 1 Patients patient NNS cord-335975-m6lkrehi 3198 2 and and CC cord-335975-m6lkrehi 3198 3 methods method NNS cord-335975-m6lkrehi 3198 4 : : : cord-335975-m6lkrehi 3198 5 We -PRON- PRP cord-335975-m6lkrehi 3198 6 included include VBD cord-335975-m6lkrehi 3198 7 retrospectively retrospectively RB cord-335975-m6lkrehi 3198 8 DMD DMD NNP cord-335975-m6lkrehi 3198 9 patients patient NNS cord-335975-m6lkrehi 3198 10 who who WP cord-335975-m6lkrehi 3198 11 experienced experience VBD cord-335975-m6lkrehi 3198 12 diaphragmatic diaphragmatic JJ cord-335975-m6lkrehi 3198 13 echography echography NN cord-335975-m6lkrehi 3198 14 and and CC cord-335975-m6lkrehi 3198 15 spirometry spirometry NN cord-335975-m6lkrehi 3198 16 in in IN cord-335975-m6lkrehi 3198 17 our -PRON- PRP$ cord-335975-m6lkrehi 3198 18 institution institution NN cord-335975-m6lkrehi 3198 19 . . . cord-335975-m6lkrehi 3199 1 Diaphragmatic diaphragmatic JJ cord-335975-m6lkrehi 3199 2 paralysis paralysis NN cord-335975-m6lkrehi 3199 3 was be VBD cord-335975-m6lkrehi 3199 4 defined define VBN cord-335975-m6lkrehi 3199 5 as as IN cord-335975-m6lkrehi 3199 6 a a DT cord-335975-m6lkrehi 3199 7 diaphragm diaphragm NN cord-335975-m6lkrehi 3199 8 with with IN cord-335975-m6lkrehi 3199 9 TF TF NNP cord-335975-m6lkrehi 3199 10 < < XX cord-335975-m6lkrehi 3199 11 20 20 CD cord-335975-m6lkrehi 3199 12 % % NN cord-335975-m6lkrehi 3199 13 . . . cord-335975-m6lkrehi 3200 1 Results result NNS cord-335975-m6lkrehi 3200 2 : : : cord-335975-m6lkrehi 3201 1 38 38 CD cord-335975-m6lkrehi 3201 2 DMD DMD NNP cord-335975-m6lkrehi 3201 3 patients patient NNS cord-335975-m6lkrehi 3201 4 were be VBD cord-335975-m6lkrehi 3201 5 included include VBN cord-335975-m6lkrehi 3201 6 in in IN cord-335975-m6lkrehi 3201 7 this this DT cord-335975-m6lkrehi 3201 8 study study NN cord-335975-m6lkrehi 3201 9 . . . cord-335975-m6lkrehi 3202 1 All all DT cord-335975-m6lkrehi 3202 2 DMD DMD NNP cord-335975-m6lkrehi 3202 3 patients patient NNS cord-335975-m6lkrehi 3202 4 were be VBD cord-335975-m6lkrehi 3202 5 wheelchair wheelchair NN cord-335975-m6lkrehi 3202 6 bound bound JJ cord-335975-m6lkrehi 3202 7 . . . cord-335975-m6lkrehi 3203 1 DMD DMD NNP cord-335975-m6lkrehi 3203 2 patients patient NNS cord-335975-m6lkrehi 3203 3 had have VBD cord-335975-m6lkrehi 3203 4 severe severe JJ cord-335975-m6lkrehi 3203 5 respiratory respiratory JJ cord-335975-m6lkrehi 3203 6 insufficiency insufficiency NN cord-335975-m6lkrehi 3203 7 with with IN cord-335975-m6lkrehi 3203 8 a a DT cord-335975-m6lkrehi 3203 9 median median JJ cord-335975-m6lkrehi 3203 10 VC vc NN cord-335975-m6lkrehi 3203 11 at at IN cord-335975-m6lkrehi 3203 12 11 11 CD cord-335975-m6lkrehi 3203 13 % % NN cord-335975-m6lkrehi 3203 14 of of IN cord-335975-m6lkrehi 3203 15 predicted predict VBN cord-335975-m6lkrehi 3203 16 value value NN cord-335975-m6lkrehi 3203 17 [ [ -LRB- cord-335975-m6lkrehi 3203 18 8 8 CD cord-335975-m6lkrehi 3203 19 ] ] -RRB- cord-335975-m6lkrehi 3203 20 [ [ -LRB- cord-335975-m6lkrehi 3203 21 9 9 CD cord-335975-m6lkrehi 3203 22 ] ] -RRB- cord-335975-m6lkrehi 3203 23 [ [ -LRB- cord-335975-m6lkrehi 3203 24 10 10 CD cord-335975-m6lkrehi 3203 25 ] ] -RRB- cord-335975-m6lkrehi 3204 1 [ [ -LRB- cord-335975-m6lkrehi 3204 2 11 11 CD cord-335975-m6lkrehi 3204 3 ] ] -RRB- cord-335975-m6lkrehi 3204 4 [ [ -LRB- cord-335975-m6lkrehi 3204 5 12 12 CD cord-335975-m6lkrehi 3204 6 ] ] -RRB- cord-335975-m6lkrehi 3204 7 [ [ -LRB- cord-335975-m6lkrehi 3204 8 13 13 CD cord-335975-m6lkrehi 3204 9 ] ] -RRB- cord-335975-m6lkrehi 3205 1 [ [ -LRB- cord-335975-m6lkrehi 3205 2 14 14 CD cord-335975-m6lkrehi 3205 3 ] ] -RRB- cord-335975-m6lkrehi 3206 1 [ [ -LRB- cord-335975-m6lkrehi 3206 2 15 15 CD cord-335975-m6lkrehi 3206 3 ] ] -RRB- cord-335975-m6lkrehi 3206 4 [ [ -LRB- cord-335975-m6lkrehi 3206 5 16 16 CD cord-335975-m6lkrehi 3206 6 ] ] -RRB- cord-335975-m6lkrehi 3206 7 [ [ -LRB- cord-335975-m6lkrehi 3206 8 17 17 CD cord-335975-m6lkrehi 3206 9 ] ] -RRB- cord-335975-m6lkrehi 3206 10 [ [ -LRB- cord-335975-m6lkrehi 3206 11 18 18 CD cord-335975-m6lkrehi 3206 12 ] ] -RRB- cord-335975-m6lkrehi 3206 13 [ [ -LRB- cord-335975-m6lkrehi 3206 14 19 19 CD cord-335975-m6lkrehi 3206 15 ] ] -RRB- cord-335975-m6lkrehi 3206 16 . . . cord-335975-m6lkrehi 3207 1 87.5 87.5 CD cord-335975-m6lkrehi 3207 2 % % NN cord-335975-m6lkrehi 3207 3 of of IN cord-335975-m6lkrehi 3207 4 patients patient NNS cord-335975-m6lkrehi 3207 5 were be VBD cord-335975-m6lkrehi 3207 6 on on IN cord-335975-m6lkrehi 3207 7 home home NN cord-335975-m6lkrehi 3207 8 mechanical mechanical JJ cord-335975-m6lkrehi 3207 9 ventilation ventilation NN cord-335975-m6lkrehi 3207 10 ( ( -LRB- cord-335975-m6lkrehi 3207 11 HMV HMV NNP cord-335975-m6lkrehi 3207 12 ) ) -RRB- cord-335975-m6lkrehi 3207 13 and and CC cord-335975-m6lkrehi 3207 14 28 28 CD cord-335975-m6lkrehi 3207 15 % % NN cord-335975-m6lkrehi 3207 16 were be VBD cord-335975-m6lkrehi 3207 17 invasively invasively RB cord-335975-m6lkrehi 3207 18 ventilated ventilate VBN cord-335975-m6lkrehi 3207 19 . . . cord-335975-m6lkrehi 3208 1 Right right JJ cord-335975-m6lkrehi 3208 2 diaphragmatic diaphragmatic JJ cord-335975-m6lkrehi 3208 3 motion motion NN cord-335975-m6lkrehi 3208 4 at at IN cord-335975-m6lkrehi 3208 5 deep deep JJ cord-335975-m6lkrehi 3208 6 inspiration inspiration NN cord-335975-m6lkrehi 3208 7 was be VBD cord-335975-m6lkrehi 3208 8 severely severely RB cord-335975-m6lkrehi 3208 9 altered alter VBN cord-335975-m6lkrehi 3208 10 with with IN cord-335975-m6lkrehi 3208 11 a a DT cord-335975-m6lkrehi 3208 12 median median NN cord-335975-m6lkrehi 3208 13 of of IN cord-335975-m6lkrehi 3208 14 8.4 8.4 CD cord-335975-m6lkrehi 3208 15 mm mm NN cord-335975-m6lkrehi 3208 16 [ [ -LRB- cord-335975-m6lkrehi 3208 17 4 4 CD cord-335975-m6lkrehi 3208 18 ] ] -RRB- cord-335975-m6lkrehi 3208 19 [ [ -LRB- cord-335975-m6lkrehi 3208 20 5 5 CD cord-335975-m6lkrehi 3208 21 ] ] -RRB- cord-335975-m6lkrehi 3208 22 [ [ -LRB- cord-335975-m6lkrehi 3208 23 6 6 CD cord-335975-m6lkrehi 3208 24 ] ] -RRB- cord-335975-m6lkrehi 3208 25 [ [ -LRB- cord-335975-m6lkrehi 3208 26 7 7 CD cord-335975-m6lkrehi 3208 27 ] ] -RRB- cord-335975-m6lkrehi 3209 1 [ [ -LRB- cord-335975-m6lkrehi 3209 2 8 8 CD cord-335975-m6lkrehi 3209 3 ] ] -RRB- cord-335975-m6lkrehi 3209 4 [ [ -LRB- cord-335975-m6lkrehi 3209 5 9 9 CD cord-335975-m6lkrehi 3209 6 ] ] -RRB- cord-335975-m6lkrehi 3209 7 [ [ -LRB- cord-335975-m6lkrehi 3209 8 10 10 CD cord-335975-m6lkrehi 3209 9 ] ] -RRB- cord-335975-m6lkrehi 3209 10 [ [ -LRB- cord-335975-m6lkrehi 3209 11 11 11 CD cord-335975-m6lkrehi 3209 12 ] ] -RRB- cord-335975-m6lkrehi 3210 1 [ [ -LRB- cord-335975-m6lkrehi 3210 2 12 12 CD cord-335975-m6lkrehi 3210 3 ] ] -RRB- cord-335975-m6lkrehi 3210 4 [ [ -LRB- cord-335975-m6lkrehi 3210 5 13 13 CD cord-335975-m6lkrehi 3210 6 ] ] -RRB- cord-335975-m6lkrehi 3210 7 . . . cord-335975-m6lkrehi 3211 1 Right right UH cord-335975-m6lkrehi 3211 2 TF tf NN cord-335975-m6lkrehi 3211 3 of of IN cord-335975-m6lkrehi 3211 4 the the DT cord-335975-m6lkrehi 3211 5 diaphragm diaphragm NN cord-335975-m6lkrehi 3211 6 was be VBD cord-335975-m6lkrehi 3211 7 severely severely RB cord-335975-m6lkrehi 3211 8 altered alter VBN cord-335975-m6lkrehi 3211 9 with with IN cord-335975-m6lkrehi 3211 10 a a DT cord-335975-m6lkrehi 3211 11 median median NN cord-335975-m6lkrehi 3211 12 of of IN cord-335975-m6lkrehi 3211 13 13 13 CD cord-335975-m6lkrehi 3211 14 . . . cord-335975-m6lkrehi 3212 1 3 3 CD cord-335975-m6lkrehi 3212 2 % % NN cord-335975-m6lkrehi 3212 3 [ [ -LRB- cord-335975-m6lkrehi 3212 4 7.7 7.7 CD cord-335975-m6lkrehi 3212 5 - - HYPH cord-335975-m6lkrehi 3212 6 27.2 27.2 CD cord-335975-m6lkrehi 3212 7 ] ] -RRB- cord-335975-m6lkrehi 3212 8 . . . cord-335975-m6lkrehi 3213 1 66.6 66.6 CD cord-335975-m6lkrehi 3213 2 % % NN cord-335975-m6lkrehi 3213 3 of of IN cord-335975-m6lkrehi 3213 4 patients patient NNS cord-335975-m6lkrehi 3213 5 disclosed disclose VBD cord-335975-m6lkrehi 3213 6 a a DT cord-335975-m6lkrehi 3213 7 paralyzed paralyzed JJ cord-335975-m6lkrehi 3213 8 diaphragm diaphragm NN cord-335975-m6lkrehi 3213 9 pattern pattern NN cord-335975-m6lkrehi 3213 10 with with IN cord-335975-m6lkrehi 3213 11 a a DT cord-335975-m6lkrehi 3213 12 right right JJ cord-335975-m6lkrehi 3213 13 TF TF NNP cord-335975-m6lkrehi 3213 14 < < XX cord-335975-m6lkrehi 3213 15 20 20 CD cord-335975-m6lkrehi 3213 16 % % NN cord-335975-m6lkrehi 3213 17 . . . cord-335975-m6lkrehi 3214 1 The the DT cord-335975-m6lkrehi 3214 2 age age NN cord-335975-m6lkrehi 3214 3 was be VBD cord-335975-m6lkrehi 3214 4 inversely inversely RB cord-335975-m6lkrehi 3214 5 correlated correlate VBN cord-335975-m6lkrehi 3214 6 with with IN cord-335975-m6lkrehi 3214 7 TF TF NNP cord-335975-m6lkrehi 3214 8 of of IN cord-335975-m6lkrehi 3214 9 the the DT cord-335975-m6lkrehi 3214 10 diaphragm diaphragm NN cord-335975-m6lkrehi 3214 11 ( ( -LRB- cord-335975-m6lkrehi 3214 12 r r NN cord-335975-m6lkrehi 3214 13 = = SYM cord-335975-m6lkrehi 3214 14 -0.56 -0.56 NN cord-335975-m6lkrehi 3214 15 , , , cord-335975-m6lkrehi 3214 16 p p NN cord-335975-m6lkrehi 3214 17 0.016 0.016 CD cord-335975-m6lkrehi 3214 18 ) ) -RRB- cord-335975-m6lkrehi 3214 19 and and CC cord-335975-m6lkrehi 3214 20 with with IN cord-335975-m6lkrehi 3214 21 the the DT cord-335975-m6lkrehi 3214 22 right right JJ cord-335975-m6lkrehi 3214 23 diaphragm diaphragm NN cord-335975-m6lkrehi 3214 24 inspiration inspiration NN cord-335975-m6lkrehi 3214 25 motion motion NN cord-335975-m6lkrehi 3214 26 ( ( -LRB- cord-335975-m6lkrehi 3214 27 r r NN cord-335975-m6lkrehi 3214 28 = = SYM cord-335975-m6lkrehi 3214 29 − − NN cord-335975-m6lkrehi 3214 30 0.68 0.68 CD cord-335975-m6lkrehi 3214 31 p p NN cord-335975-m6lkrehi 3214 32 < < XX cord-335975-m6lkrehi 3214 33 0.0001 0.0001 CD cord-335975-m6lkrehi 3214 34 ) ) -RRB- cord-335975-m6lkrehi 3214 35 . . . cord-335975-m6lkrehi 3215 1 Patients patient NNS cord-335975-m6lkrehi 3215 2 with with IN cord-335975-m6lkrehi 3215 3 diaphragm diaphragm NN cord-335975-m6lkrehi 3215 4 paralysis paralysis NN cord-335975-m6lkrehi 3215 5 were be VBD cord-335975-m6lkrehi 3215 6 older old JJR cord-335975-m6lkrehi 3215 7 with with IN cord-335975-m6lkrehi 3215 8 median median JJ cord-335975-m6lkrehi 3215 9 age age NN cord-335975-m6lkrehi 3215 10 at at IN cord-335975-m6lkrehi 3215 11 32.5 32.5 CD cord-335975-m6lkrehi 3215 12 years year NNS cord-335975-m6lkrehi 3215 13 [ [ -LRB- cord-335975-m6lkrehi 3215 14 31 31 CD cord-335975-m6lkrehi 3215 15 - - SYM cord-335975-m6lkrehi 3215 16 39.5 39.5 CD cord-335975-m6lkrehi 3215 17 ] ] -RRB- cord-335975-m6lkrehi 3215 18 , , , cord-335975-m6lkrehi 3215 19 with with IN cord-335975-m6lkrehi 3215 20 severe severe JJ cord-335975-m6lkrehi 3215 21 respiratory respiratory JJ cord-335975-m6lkrehi 3215 22 impairment impairment NN cord-335975-m6lkrehi 3215 23 ( ( -LRB- cord-335975-m6lkrehi 3215 24 median median NN cord-335975-m6lkrehi 3215 25 sitting sit VBG cord-335975-m6lkrehi 3215 26 CV cv NN cord-335975-m6lkrehi 3215 27 = = SYM cord-335975-m6lkrehi 3215 28 6 6 CD cord-335975-m6lkrehi 3215 29 % % NN cord-335975-m6lkrehi 3215 30 ) ) -RRB- cord-335975-m6lkrehi 3215 31 and and CC cord-335975-m6lkrehi 3215 32 median median JJ cord-335975-m6lkrehi 3215 33 cumulated cumulate VBD cord-335975-m6lkrehi 3215 34 annual annual JJ cord-335975-m6lkrehi 3215 35 HMV HMV NNP cord-335975-m6lkrehi 3215 36 duration duration NN cord-335975-m6lkrehi 3215 37 at at IN cord-335975-m6lkrehi 3215 38 12.5 12.5 CD cord-335975-m6lkrehi 3215 39 years year NNS cord-335975-m6lkrehi 3215 40 . . . cord-335975-m6lkrehi 3216 1 Conclusion conclusion NN cord-335975-m6lkrehi 3216 2 : : : cord-335975-m6lkrehi 3216 3 In in IN cord-335975-m6lkrehi 3216 4 DMD DMD NNP cord-335975-m6lkrehi 3216 5 , , , cord-335975-m6lkrehi 3216 6 age age NN cord-335975-m6lkrehi 3216 7 is be VBZ cord-335975-m6lkrehi 3216 8 inversely inversely RB cord-335975-m6lkrehi 3216 9 correlated correlate VBN cord-335975-m6lkrehi 3216 10 with with IN cord-335975-m6lkrehi 3216 11 diaphragm diaphragm NN cord-335975-m6lkrehi 3216 12 function function NN cord-335975-m6lkrehi 3216 13 . . . cord-335975-m6lkrehi 3217 1 Diaphragm diaphragm NN cord-335975-m6lkrehi 3217 2 paralysis paralysis NN cord-335975-m6lkrehi 3217 3 is be VBZ cord-335975-m6lkrehi 3217 4 frequent frequent JJ cord-335975-m6lkrehi 3217 5 in in IN cord-335975-m6lkrehi 3217 6 older old JJR cord-335975-m6lkrehi 3217 7 adult adult NN cord-335975-m6lkrehi 3217 8 non non JJ cord-335975-m6lkrehi 3217 9 - - JJ cord-335975-m6lkrehi 3217 10 ambulant ambulant JJ cord-335975-m6lkrehi 3217 11 DMD DMD NNP cord-335975-m6lkrehi 3217 12 . . . cord-335975-m6lkrehi 3217 13 . . . cord-335975-m6lkrehi 3218 1 The the DT cord-335975-m6lkrehi 3218 2 final final JJ cord-335975-m6lkrehi 3218 3 probability probability NN cord-335975-m6lkrehi 3218 4 model model NN cord-335975-m6lkrehi 3218 5 included include VBD cord-335975-m6lkrehi 3218 6 the the DT cord-335975-m6lkrehi 3218 7 previous previous JJ cord-335975-m6lkrehi 3218 8 identified identify VBN cord-335975-m6lkrehi 3218 9 factors factor NNS cord-335975-m6lkrehi 3218 10 in in IN cord-335975-m6lkrehi 3218 11 addition addition NN cord-335975-m6lkrehi 3218 12 to to IN cord-335975-m6lkrehi 3218 13 age age NN cord-335975-m6lkrehi 3218 14 and and CC cord-335975-m6lkrehi 3218 15 SAPS SAPS NNP cord-335975-m6lkrehi 3218 16 II II NNP cord-335975-m6lkrehi 3218 17 score score NN cord-335975-m6lkrehi 3218 18 , , , cord-335975-m6lkrehi 3218 19 this this DT cord-335975-m6lkrehi 3218 20 model model NN cord-335975-m6lkrehi 3218 21 exhibited exhibit VBD cord-335975-m6lkrehi 3218 22 good good JJ cord-335975-m6lkrehi 3218 23 calibration calibration NN cord-335975-m6lkrehi 3218 24 ( ( -LRB- cord-335975-m6lkrehi 3218 25 Hosmer Hosmer NNP cord-335975-m6lkrehi 3218 26 - - HYPH cord-335975-m6lkrehi 3218 27 Lemeshow Lemeshow NNP cord-335975-m6lkrehi 3218 28 X X NNP cord-335975-m6lkrehi 3218 29 2 2 CD cord-335975-m6lkrehi 3218 30 , , , cord-335975-m6lkrehi 3218 31 p p NN cord-335975-m6lkrehi 3218 32 = = SYM cord-335975-m6lkrehi 3218 33 .98 .98 NFP cord-335975-m6lkrehi 3218 34 ) ) -RRB- cord-335975-m6lkrehi 3218 35 and and CC cord-335975-m6lkrehi 3218 36 good good JJ cord-335975-m6lkrehi 3218 37 discrimination discrimination NN cord-335975-m6lkrehi 3218 38 ( ( -LRB- cord-335975-m6lkrehi 3218 39 ROC ROC NNP cord-335975-m6lkrehi 3218 40 - - HYPH cord-335975-m6lkrehi 3218 41 AUC AUC NNP cord-335975-m6lkrehi 3218 42 , , , cord-335975-m6lkrehi 3218 43 0.94 0.94 CD cord-335975-m6lkrehi 3218 44 + + SYM cord-335975-m6lkrehi 3218 45 95 95 CD cord-335975-m6lkrehi 3218 46 % % NN cord-335975-m6lkrehi 3218 47 confidence confidence NN cord-335975-m6lkrehi 3218 48 interval interval NN cord-335975-m6lkrehi 3218 49 , , , cord-335975-m6lkrehi 3218 50 0.92 0.92 CD cord-335975-m6lkrehi 3218 51 - - HYPH cord-335975-m6lkrehi 3218 52 0.96 0.96 CD cord-335975-m6lkrehi 3218 53 ) ) -RRB- cord-335975-m6lkrehi 3218 54 ( ( -LRB- cord-335975-m6lkrehi 3218 55 Fig Fig NNP cord-335975-m6lkrehi 3218 56 . . NNP cord-335975-m6lkrehi 3218 57 1 1 CD cord-335975-m6lkrehi 3218 58 ) ) -RRB- cord-335975-m6lkrehi 3218 59 . . . cord-335975-m6lkrehi 3219 1 Conclusion conclusion NN cord-335975-m6lkrehi 3219 2 : : : cord-335975-m6lkrehi 3220 1 Our -PRON- PRP$ cord-335975-m6lkrehi 3220 2 cohort cohort NN cord-335975-m6lkrehi 3220 3 study study NN cord-335975-m6lkrehi 3220 4 identified identify VBD cord-335975-m6lkrehi 3220 5 risk risk NN cord-335975-m6lkrehi 3220 6 factors factor NNS cord-335975-m6lkrehi 3220 7 of of IN cord-335975-m6lkrehi 3220 8 ICU ICU NNP cord-335975-m6lkrehi 3220 9 death death NN cord-335975-m6lkrehi 3220 10 , , , cord-335975-m6lkrehi 3220 11 mainly mainly RB cord-335975-m6lkrehi 3220 12 collected collect VBN cord-335975-m6lkrehi 3220 13 at at IN cord-335975-m6lkrehi 3220 14 admission admission NN cord-335975-m6lkrehi 3220 15 among among IN cord-335975-m6lkrehi 3220 16 patients patient NNS cord-335975-m6lkrehi 3220 17 with with IN cord-335975-m6lkrehi 3220 18 AECOPD AECOPD NNP cord-335975-m6lkrehi 3220 19 . . . cord-335975-m6lkrehi 3221 1 The the DT cord-335975-m6lkrehi 3221 2 proposed propose VBN cord-335975-m6lkrehi 3221 3 probability probability NN cord-335975-m6lkrehi 3221 4 model model NN cord-335975-m6lkrehi 3221 5 has have VBZ cord-335975-m6lkrehi 3221 6 a a DT cord-335975-m6lkrehi 3221 7 good good JJ cord-335975-m6lkrehi 3221 8 performance performance NN cord-335975-m6lkrehi 3221 9 in in IN cord-335975-m6lkrehi 3221 10 predicting predict VBG cord-335975-m6lkrehi 3221 11 the the DT cord-335975-m6lkrehi 3221 12 short short JJ cord-335975-m6lkrehi 3221 13 - - HYPH cord-335975-m6lkrehi 3221 14 term term NN cord-335975-m6lkrehi 3221 15 prognosis prognosis NN cord-335975-m6lkrehi 3221 16 . . . cord-335975-m6lkrehi 3222 1 Further further JJ cord-335975-m6lkrehi 3222 2 evaluation evaluation NN cord-335975-m6lkrehi 3222 3 in in IN cord-335975-m6lkrehi 3222 4 other other JJ cord-335975-m6lkrehi 3222 5 cohorts cohort NNS cord-335975-m6lkrehi 3222 6 is be VBZ cord-335975-m6lkrehi 3222 7 needed need VBN cord-335975-m6lkrehi 3222 8 . . . cord-335975-m6lkrehi 3223 1 Introduction introduction NN cord-335975-m6lkrehi 3223 2 : : : cord-335975-m6lkrehi 3224 1 Precarity Precarity NNP cord-335975-m6lkrehi 3224 2 is be VBZ cord-335975-m6lkrehi 3224 3 a a DT cord-335975-m6lkrehi 3224 4 complex complex JJ cord-335975-m6lkrehi 3224 5 notion notion NN cord-335975-m6lkrehi 3224 6 including include VBG cord-335975-m6lkrehi 3224 7 several several JJ cord-335975-m6lkrehi 3224 8 components component NNS cord-335975-m6lkrehi 3224 9 , , , cord-335975-m6lkrehi 3224 10 and and CC cord-335975-m6lkrehi 3224 11 its -PRON- PRP$ cord-335975-m6lkrehi 3224 12 definition definition NN cord-335975-m6lkrehi 3224 13 is be VBZ cord-335975-m6lkrehi 3224 14 still still RB cord-335975-m6lkrehi 3224 15 debated debate VBN cord-335975-m6lkrehi 3224 16 . . . cord-335975-m6lkrehi 3225 1 It -PRON- PRP cord-335975-m6lkrehi 3225 2 is be VBZ cord-335975-m6lkrehi 3225 3 more more RBR cord-335975-m6lkrehi 3225 4 subtle subtle JJ cord-335975-m6lkrehi 3225 5 than than IN cord-335975-m6lkrehi 3225 6 financial financial JJ cord-335975-m6lkrehi 3225 7 poverty poverty NN cord-335975-m6lkrehi 3225 8 alone alone RB cord-335975-m6lkrehi 3225 9 , , , cord-335975-m6lkrehi 3225 10 and and CC cord-335975-m6lkrehi 3225 11 can can MD cord-335975-m6lkrehi 3225 12 increase increase VB cord-335975-m6lkrehi 3225 13 population population NN cord-335975-m6lkrehi 3225 14 's 's POS cord-335975-m6lkrehi 3225 15 health health NN cord-335975-m6lkrehi 3225 16 insecurity insecurity NN cord-335975-m6lkrehi 3225 17 . . . cord-335975-m6lkrehi 3226 1 We -PRON- PRP cord-335975-m6lkrehi 3226 2 hypothesize hypothesize VBP cord-335975-m6lkrehi 3226 3 that that IN cord-335975-m6lkrehi 3226 4 patients patient NNS cord-335975-m6lkrehi 3226 5 with with IN cord-335975-m6lkrehi 3226 6 precarity precarity NN cord-335975-m6lkrehi 3226 7 features feature NNS cord-335975-m6lkrehi 3226 8 may may MD cord-335975-m6lkrehi 3226 9 have have VB cord-335975-m6lkrehi 3226 10 different different JJ cord-335975-m6lkrehi 3226 11 epidemiologic epidemiologic JJ cord-335975-m6lkrehi 3226 12 characteristics characteristic NNS cord-335975-m6lkrehi 3226 13 and and CC cord-335975-m6lkrehi 3226 14 ICU ICU NNP cord-335975-m6lkrehi 3226 15 outcomes outcome NNS cord-335975-m6lkrehi 3226 16 than than IN cord-335975-m6lkrehi 3226 17 the the DT cord-335975-m6lkrehi 3226 18 general general JJ cord-335975-m6lkrehi 3226 19 population population NN cord-335975-m6lkrehi 3226 20 . . . cord-335975-m6lkrehi 3227 1 The the DT cord-335975-m6lkrehi 3227 2 aim aim NN cord-335975-m6lkrehi 3227 3 of of IN cord-335975-m6lkrehi 3227 4 this this DT cord-335975-m6lkrehi 3227 5 study study NN cord-335975-m6lkrehi 3227 6 was be VBD cord-335975-m6lkrehi 3227 7 to to TO cord-335975-m6lkrehi 3227 8 describe describe VB cord-335975-m6lkrehi 3227 9 precarity precarity NN cord-335975-m6lkrehi 3227 10 features feature NNS cord-335975-m6lkrehi 3227 11 and and CC cord-335975-m6lkrehi 3227 12 outcomes outcome NNS cord-335975-m6lkrehi 3227 13 of of IN cord-335975-m6lkrehi 3227 14 patients patient NNS cord-335975-m6lkrehi 3227 15 admitted admit VBN cord-335975-m6lkrehi 3227 16 to to IN cord-335975-m6lkrehi 3227 17 an an DT cord-335975-m6lkrehi 3227 18 ICU ICU NNP cord-335975-m6lkrehi 3227 19 located locate VBN cord-335975-m6lkrehi 3227 20 in in IN cord-335975-m6lkrehi 3227 21 a a DT cord-335975-m6lkrehi 3227 22 high high JJ cord-335975-m6lkrehi 3227 23 poverty poverty NN cord-335975-m6lkrehi 3227 24 rate rate NN cord-335975-m6lkrehi 3227 25 territory territory NN cord-335975-m6lkrehi 3227 26 . . . cord-335975-m6lkrehi 3228 1 Patients patient NNS cord-335975-m6lkrehi 3228 2 and and CC cord-335975-m6lkrehi 3228 3 methods method NNS cord-335975-m6lkrehi 3229 1 : : : cord-335975-m6lkrehi 3229 2 We -PRON- PRP cord-335975-m6lkrehi 3229 3 conducted conduct VBD cord-335975-m6lkrehi 3229 4 a a DT cord-335975-m6lkrehi 3229 5 prospective prospective JJ cord-335975-m6lkrehi 3229 6 single single JJ cord-335975-m6lkrehi 3229 7 - - HYPH cord-335975-m6lkrehi 3229 8 center center NN cord-335975-m6lkrehi 3229 9 observational observational JJ cord-335975-m6lkrehi 3229 10 study study NN cord-335975-m6lkrehi 3229 11 of of IN cord-335975-m6lkrehi 3229 12 all all DT cord-335975-m6lkrehi 3229 13 patients patient NNS cord-335975-m6lkrehi 3229 14 admitted admit VBN cord-335975-m6lkrehi 3229 15 to to IN cord-335975-m6lkrehi 3229 16 ICU ICU NNP cord-335975-m6lkrehi 3229 17 of of IN cord-335975-m6lkrehi 3229 18 the the DT cord-335975-m6lkrehi 3229 19 Saint Saint NNP cord-335975-m6lkrehi 3229 20 - - HYPH cord-335975-m6lkrehi 3229 21 Denis Denis NNP cord-335975-m6lkrehi 3229 22 _SP cord-335975-m6lkrehi 3229 23 general general JJ cord-335975-m6lkrehi 3229 24 hospital hospital NN cord-335975-m6lkrehi 3229 25 , , , cord-335975-m6lkrehi 3229 26 from from IN cord-335975-m6lkrehi 3229 27 February February NNP cord-335975-m6lkrehi 3229 28 to to IN cord-335975-m6lkrehi 3229 29 July July NNP cord-335975-m6lkrehi 3229 30 2017 2017 CD cord-335975-m6lkrehi 3229 31 . . . cord-335975-m6lkrehi 3230 1 Precarity precarity NN cord-335975-m6lkrehi 3230 2 features feature NNS cord-335975-m6lkrehi 3230 3 were be VBD cord-335975-m6lkrehi 3230 4 classified classify VBN cord-335975-m6lkrehi 3230 5 in in IN cord-335975-m6lkrehi 3230 6 4 4 CD cord-335975-m6lkrehi 3230 7 categories category NNS cord-335975-m6lkrehi 3230 8 - - : cord-335975-m6lkrehi 3230 9 absence absence NN cord-335975-m6lkrehi 3230 10 of of IN cord-335975-m6lkrehi 3230 11 health health NN cord-335975-m6lkrehi 3230 12 insurance insurance NN cord-335975-m6lkrehi 3230 13 , , , cord-335975-m6lkrehi 3230 14 lack lack NN cord-335975-m6lkrehi 3230 15 of of IN cord-335975-m6lkrehi 3230 16 incomes income NNS cord-335975-m6lkrehi 3230 17 or or CC cord-335975-m6lkrehi 3230 18 minimum minimum JJ cord-335975-m6lkrehi 3230 19 allowances allowance NNS cord-335975-m6lkrehi 3230 20 , , , cord-335975-m6lkrehi 3230 21 homelessness homelessness NN cord-335975-m6lkrehi 3230 22 or or CC cord-335975-m6lkrehi 3230 23 social social JJ cord-335975-m6lkrehi 3230 24 home home NN cord-335975-m6lkrehi 3230 25 or or CC cord-335975-m6lkrehi 3230 26 hotel hotel NN cord-335975-m6lkrehi 3230 27 , , , cord-335975-m6lkrehi 3230 28 and and CC cord-335975-m6lkrehi 3230 29 social social JJ cord-335975-m6lkrehi 3230 30 isolation isolation NN cord-335975-m6lkrehi 3230 31 ( ( -LRB- cord-335975-m6lkrehi 3230 32 no no DT cord-335975-m6lkrehi 3230 33 social social JJ cord-335975-m6lkrehi 3230 34 link link NN cord-335975-m6lkrehi 3230 35 , , , cord-335975-m6lkrehi 3230 36 or or CC cord-335975-m6lkrehi 3230 37 associations association NNS cord-335975-m6lkrehi 3230 38 or or CC cord-335975-m6lkrehi 3230 39 neighbors neighbor NNS cord-335975-m6lkrehi 3230 40 ) ) -RRB- cord-335975-m6lkrehi 3230 41 . . . cord-335975-m6lkrehi 3231 1 Others other NNS cord-335975-m6lkrehi 3231 2 social social JJ cord-335975-m6lkrehi 3231 3 data datum NNS cord-335975-m6lkrehi 3231 4 were be VBD cord-335975-m6lkrehi 3231 5 collected collect VBN cord-335975-m6lkrehi 3231 6 ( ( -LRB- cord-335975-m6lkrehi 3231 7 speaking speak VBG cord-335975-m6lkrehi 3231 8 fluent fluent JJ cord-335975-m6lkrehi 3231 9 French french JJ cord-335975-m6lkrehi 3231 10 and and CC cord-335975-m6lkrehi 3231 11 education education NN cord-335975-m6lkrehi 3231 12 level level NN cord-335975-m6lkrehi 3231 13 ) ) -RRB- cord-335975-m6lkrehi 3231 14 as as RB cord-335975-m6lkrehi 3231 15 well well RB cord-335975-m6lkrehi 3231 16 as as IN cord-335975-m6lkrehi 3231 17 usual usual JJ cord-335975-m6lkrehi 3231 18 clinical clinical JJ cord-335975-m6lkrehi 3231 19 ICU ICU NNP cord-335975-m6lkrehi 3231 20 data datum NNS cord-335975-m6lkrehi 3231 21 . . . cord-335975-m6lkrehi 3232 1 Results result NNS cord-335975-m6lkrehi 3232 2 : : : cord-335975-m6lkrehi 3233 1 Among among IN cord-335975-m6lkrehi 3233 2 241 241 CD cord-335975-m6lkrehi 3233 3 patients patient NNS cord-335975-m6lkrehi 3233 4 included include VBN cord-335975-m6lkrehi 3233 5 , , , cord-335975-m6lkrehi 3233 6 precarity precarity NN cord-335975-m6lkrehi 3233 7 features feature NNS cord-335975-m6lkrehi 3233 8 were be VBD cord-335975-m6lkrehi 3233 9 found find VBN cord-335975-m6lkrehi 3233 10 in in IN cord-335975-m6lkrehi 3233 11 83 83 CD cord-335975-m6lkrehi 3233 12 patients patient NNS cord-335975-m6lkrehi 3233 13 ( ( -LRB- cord-335975-m6lkrehi 3233 14 35.3 35.3 CD cord-335975-m6lkrehi 3233 15 % % NN cord-335975-m6lkrehi 3233 16 ) ) -RRB- cord-335975-m6lkrehi 3233 17 . . . cord-335975-m6lkrehi 3234 1 Income income NN cord-335975-m6lkrehi 3234 2 precarity precarity NN cord-335975-m6lkrehi 3234 3 was be VBD cord-335975-m6lkrehi 3234 4 the the DT cord-335975-m6lkrehi 3234 5 most most RBS cord-335975-m6lkrehi 3234 6 common common JJ cord-335975-m6lkrehi 3234 7 , , , cord-335975-m6lkrehi 3234 8 followed follow VBN cord-335975-m6lkrehi 3234 9 by by IN cord-335975-m6lkrehi 3234 10 accommodation accommodation NN cord-335975-m6lkrehi 3234 11 precarity precarity NN cord-335975-m6lkrehi 3234 12 , , , cord-335975-m6lkrehi 3234 13 health health NN cord-335975-m6lkrehi 3234 14 precarity precarity NN cord-335975-m6lkrehi 3234 15 and and CC cord-335975-m6lkrehi 3234 16 relation relation NN cord-335975-m6lkrehi 3234 17 precarity precarity NN cord-335975-m6lkrehi 3234 18 ( ( -LRB- cord-335975-m6lkrehi 3234 19 Table table NN cord-335975-m6lkrehi 3234 20 1 1 CD cord-335975-m6lkrehi 3234 21 ) ) -RRB- cord-335975-m6lkrehi 3234 22 . . . cord-335975-m6lkrehi 3235 1 Precarity Precarity NNP cord-335975-m6lkrehi 3235 2 was be VBD cord-335975-m6lkrehi 3235 3 not not RB cord-335975-m6lkrehi 3235 4 associated associate VBN cord-335975-m6lkrehi 3235 5 with with IN cord-335975-m6lkrehi 3235 6 hospital hospital NN cord-335975-m6lkrehi 3235 7 mortality mortality NN cord-335975-m6lkrehi 3235 8 ( ( -LRB- cord-335975-m6lkrehi 3235 9 37 37 CD cord-335975-m6lkrehi 3235 10 vs. vs. NN cord-335975-m6lkrehi 3235 11 25.7 25.7 CD cord-335975-m6lkrehi 3235 12 % % NN cord-335975-m6lkrehi 3235 13 , , , cord-335975-m6lkrehi 3235 14 p p NN cord-335975-m6lkrehi 3235 15 = = SYM cord-335975-m6lkrehi 3235 16 0.20 0.20 CD cord-335975-m6lkrehi 3235 17 ) ) -RRB- cord-335975-m6lkrehi 3235 18 . . . cord-335975-m6lkrehi 3236 1 All all DT cord-335975-m6lkrehi 3236 2 types type NNS cord-335975-m6lkrehi 3236 3 of of IN cord-335975-m6lkrehi 3236 4 precarity precarity NN cord-335975-m6lkrehi 3236 5 were be VBD cord-335975-m6lkrehi 3236 6 significantly significantly RB cord-335975-m6lkrehi 3236 7 associated associate VBN cord-335975-m6lkrehi 3236 8 with with IN cord-335975-m6lkrehi 3236 9 each each DT cord-335975-m6lkrehi 3236 10 other other JJ cord-335975-m6lkrehi 3236 11 . . . cord-335975-m6lkrehi 3237 1 Precarious precarious JJ cord-335975-m6lkrehi 3237 2 patients patient NNS cord-335975-m6lkrehi 3237 3 were be VBD cord-335975-m6lkrehi 3237 4 younger young JJR cord-335975-m6lkrehi 3237 5 ( ( -LRB- cord-335975-m6lkrehi 3237 6 63 63 CD cord-335975-m6lkrehi 3237 7 vs. vs. NN cord-335975-m6lkrehi 3237 8 40 40 CD cord-335975-m6lkrehi 3237 9 years year NNS cord-335975-m6lkrehi 3237 10 - - HYPH cord-335975-m6lkrehi 3237 11 old old JJ cord-335975-m6lkrehi 3237 12 , , , cord-335975-m6lkrehi 3237 13 p p NN cord-335975-m6lkrehi 3237 14 < < XX cord-335975-m6lkrehi 3237 15 .01 .01 NFP cord-335975-m6lkrehi 3237 16 ) ) -RRB- cord-335975-m6lkrehi 3237 17 and and CC cord-335975-m6lkrehi 3237 18 had have VBD cord-335975-m6lkrehi 3237 19 less less JJR cord-335975-m6lkrehi 3237 20 comorbidities comorbiditie NNS cord-335975-m6lkrehi 3237 21 . . . cord-335975-m6lkrehi 3238 1 We -PRON- PRP cord-335975-m6lkrehi 3238 2 found find VBD cord-335975-m6lkrehi 3238 3 no no DT cord-335975-m6lkrehi 3238 4 differences difference NNS cord-335975-m6lkrehi 3238 5 concerning concern VBG cord-335975-m6lkrehi 3238 6 hospital hospital NN cord-335975-m6lkrehi 3238 7 or or CC cord-335975-m6lkrehi 3238 8 ICU ICU NNP cord-335975-m6lkrehi 3238 9 length length NN cord-335975-m6lkrehi 3238 10 of of IN cord-335975-m6lkrehi 3238 11 stay stay NN cord-335975-m6lkrehi 3238 12 ( ( -LRB- cord-335975-m6lkrehi 3238 13 12 12 CD cord-335975-m6lkrehi 3238 14 vs. vs. NN cord-335975-m6lkrehi 3238 15 11 11 CD cord-335975-m6lkrehi 3238 16 days day NNS cord-335975-m6lkrehi 3238 17 , , , cord-335975-m6lkrehi 3238 18 p p NN cord-335975-m6lkrehi 3238 19 = = SYM cord-335975-m6lkrehi 3238 20 0.53 0.53 CD cord-335975-m6lkrehi 3238 21 ) ) -RRB- cord-335975-m6lkrehi 3238 22 or or CC cord-335975-m6lkrehi 3238 23 concerning concern VBG cord-335975-m6lkrehi 3238 24 education education NN cord-335975-m6lkrehi 3238 25 level level NN cord-335975-m6lkrehi 3238 26 between between IN cord-335975-m6lkrehi 3238 27 precarious precarious JJ cord-335975-m6lkrehi 3238 28 patients patient NNS cord-335975-m6lkrehi 3238 29 and and CC cord-335975-m6lkrehi 3238 30 the the DT cord-335975-m6lkrehi 3238 31 others other NNS cord-335975-m6lkrehi 3238 32 . . . cord-335975-m6lkrehi 3239 1 Conclusion conclusion NN cord-335975-m6lkrehi 3239 2 : : : cord-335975-m6lkrehi 3240 1 Our -PRON- PRP$ cord-335975-m6lkrehi 3240 2 pilot pilot NN cord-335975-m6lkrehi 3240 3 study study NN cord-335975-m6lkrehi 3240 4 shows show VBZ cord-335975-m6lkrehi 3240 5 that that IN cord-335975-m6lkrehi 3240 6 precarity precarity NN cord-335975-m6lkrehi 3240 7 features feature NNS cord-335975-m6lkrehi 3240 8 are be VBP cord-335975-m6lkrehi 3240 9 indeed indeed RB cord-335975-m6lkrehi 3240 10 very very RB cord-335975-m6lkrehi 3240 11 frequent frequent JJ cord-335975-m6lkrehi 3240 12 and and CC cord-335975-m6lkrehi 3240 13 are be VBP cord-335975-m6lkrehi 3240 14 often often RB cord-335975-m6lkrehi 3240 15 cumulated cumulate VBN cord-335975-m6lkrehi 3240 16 . . . cord-335975-m6lkrehi 3241 1 With with IN cord-335975-m6lkrehi 3241 2 respect respect NN cord-335975-m6lkrehi 3241 3 to to IN cord-335975-m6lkrehi 3241 4 the the DT cord-335975-m6lkrehi 3241 5 small small JJ cord-335975-m6lkrehi 3241 6 patient patient NN cord-335975-m6lkrehi 3241 7 sample sample NN cord-335975-m6lkrehi 3241 8 , , , cord-335975-m6lkrehi 3241 9 precarity precarity NN cord-335975-m6lkrehi 3241 10 does do VBZ cord-335975-m6lkrehi 3241 11 not not RB cord-335975-m6lkrehi 3241 12 seems seem VBZ cord-335975-m6lkrehi 3241 13 to to TO cord-335975-m6lkrehi 3241 14 be be VB cord-335975-m6lkrehi 3241 15 associated associate VBN cord-335975-m6lkrehi 3241 16 with with IN cord-335975-m6lkrehi 3241 17 hospital hospital NN cord-335975-m6lkrehi 3241 18 mortality mortality NN cord-335975-m6lkrehi 3241 19 or or CC cord-335975-m6lkrehi 3241 20 length length NN cord-335975-m6lkrehi 3241 21 of of IN cord-335975-m6lkrehi 3241 22 stay stay NN cord-335975-m6lkrehi 3241 23 . . . cord-335975-m6lkrehi 3242 1 Further further JJ cord-335975-m6lkrehi 3242 2 investigations investigation NNS cord-335975-m6lkrehi 3242 3 with with IN cord-335975-m6lkrehi 3242 4 larger large JJR cord-335975-m6lkrehi 3242 5 patient patient NN cord-335975-m6lkrehi 3242 6 samples sample NNS cord-335975-m6lkrehi 3242 7 and and CC cord-335975-m6lkrehi 3242 8 multicenter multicenter JJ cord-335975-m6lkrehi 3242 9 designs design NNS cord-335975-m6lkrehi 3242 10 are be VBP cord-335975-m6lkrehi 3242 11 warranted warrant VBN cord-335975-m6lkrehi 3242 12 to to TO cord-335975-m6lkrehi 3242 13 investigate investigate VB cord-335975-m6lkrehi 3242 14 properly properly RB cord-335975-m6lkrehi 3242 15 the the DT cord-335975-m6lkrehi 3242 16 impact impact NN cord-335975-m6lkrehi 3242 17 of of IN cord-335975-m6lkrehi 3242 18 precarity precarity NN cord-335975-m6lkrehi 3242 19 on on IN cord-335975-m6lkrehi 3242 20 ICU ICU NNP cord-335975-m6lkrehi 3242 21 management management NN cord-335975-m6lkrehi 3242 22 and and CC cord-335975-m6lkrehi 3242 23 outcomes outcome NNS cord-335975-m6lkrehi 3242 24 . . . cord-335975-m6lkrehi 3243 1 Introduction introduction NN cord-335975-m6lkrehi 3243 2 : : : cord-335975-m6lkrehi 3244 1 Population population NN cord-335975-m6lkrehi 3244 2 aging aging NN cord-335975-m6lkrehi 3244 3 is be VBZ cord-335975-m6lkrehi 3244 4 a a DT cord-335975-m6lkrehi 3244 5 global global JJ cord-335975-m6lkrehi 3244 6 and and CC cord-335975-m6lkrehi 3244 7 expanding expand VBG cord-335975-m6lkrehi 3244 8 phenomenon phenomenon NN cord-335975-m6lkrehi 3244 9 . . . cord-335975-m6lkrehi 3245 1 Elderly elderly JJ cord-335975-m6lkrehi 3245 2 people people NNS cord-335975-m6lkrehi 3245 3 are be VBP cord-335975-m6lkrehi 3245 4 particularly particularly RB cord-335975-m6lkrehi 3245 5 vulnerable vulnerable JJ cord-335975-m6lkrehi 3245 6 , , , cord-335975-m6lkrehi 3245 7 and and CC cord-335975-m6lkrehi 3245 8 often often RB cord-335975-m6lkrehi 3245 9 need need VBP cord-335975-m6lkrehi 3245 10 health health NN cord-335975-m6lkrehi 3245 11 care care NN cord-335975-m6lkrehi 3245 12 . . . cord-335975-m6lkrehi 3246 1 This this DT cord-335975-m6lkrehi 3246 2 demographic demographic JJ cord-335975-m6lkrehi 3246 3 evolution evolution NN cord-335975-m6lkrehi 3246 4 also also RB cord-335975-m6lkrehi 3246 5 affects affect VBZ cord-335975-m6lkrehi 3246 6 Intensive Intensive NNP cord-335975-m6lkrehi 3246 7 Care Care NNP cord-335975-m6lkrehi 3246 8 Units Units NNPS cord-335975-m6lkrehi 3246 9 , , , cord-335975-m6lkrehi 3246 10 and and CC cord-335975-m6lkrehi 3246 11 80 80 CD cord-335975-m6lkrehi 3246 12 years year NNS cord-335975-m6lkrehi 3246 13 old old JJ cord-335975-m6lkrehi 3246 14 patient patient NN cord-335975-m6lkrehi 3246 15 are be VBP cord-335975-m6lkrehi 3246 16 now now RB cord-335975-m6lkrehi 3246 17 frequently frequently RB cord-335975-m6lkrehi 3246 18 admitted admit VBN cord-335975-m6lkrehi 3246 19 - - : cord-335975-m6lkrehi 3246 20 it -PRON- PRP cord-335975-m6lkrehi 3246 21 corresponds correspond VBZ cord-335975-m6lkrehi 3246 22 to to IN cord-335975-m6lkrehi 3246 23 15 15 CD cord-335975-m6lkrehi 3246 24 % % NN cord-335975-m6lkrehi 3246 25 of of IN cord-335975-m6lkrehi 3246 26 admission admission NN cord-335975-m6lkrehi 3246 27 in in IN cord-335975-m6lkrehi 3246 28 France France NNP cord-335975-m6lkrehi 3246 29 . . . cord-335975-m6lkrehi 3247 1 Indeed indeed RB cord-335975-m6lkrehi 3247 2 we -PRON- PRP cord-335975-m6lkrehi 3247 3 have have VBP cord-335975-m6lkrehi 3247 4 analyzed analyze VBN cord-335975-m6lkrehi 3247 5 the the DT cord-335975-m6lkrehi 3247 6 change change NN cord-335975-m6lkrehi 3247 7 in in IN cord-335975-m6lkrehi 3247 8 management management NN cord-335975-m6lkrehi 3247 9 of of IN cord-335975-m6lkrehi 3247 10 this this DT cord-335975-m6lkrehi 3247 11 very very RB cord-335975-m6lkrehi 3247 12 elderly elderly JJ cord-335975-m6lkrehi 3247 13 people people NNS cord-335975-m6lkrehi 3247 14 ( ( -LRB- cord-335975-m6lkrehi 3247 15 80 80 CD cord-335975-m6lkrehi 3247 16 years year NNS cord-335975-m6lkrehi 3247 17 old old JJ cord-335975-m6lkrehi 3247 18 and and CC cord-335975-m6lkrehi 3247 19 more more RBR cord-335975-m6lkrehi 3247 20 ) ) -RRB- cord-335975-m6lkrehi 3247 21 over over IN cord-335975-m6lkrehi 3247 22 the the DT cord-335975-m6lkrehi 3247 23 past past JJ cord-335975-m6lkrehi 3247 24 14 14 CD cord-335975-m6lkrehi 3247 25 years year NNS cord-335975-m6lkrehi 3247 26 in in IN cord-335975-m6lkrehi 3247 27 a a DT cord-335975-m6lkrehi 3247 28 French french JJ cord-335975-m6lkrehi 3247 29 medical medical JJ cord-335975-m6lkrehi 3247 30 intensive intensive JJ cord-335975-m6lkrehi 3247 31 care care NN cord-335975-m6lkrehi 3247 32 unit unit NN cord-335975-m6lkrehi 3247 33 in in IN cord-335975-m6lkrehi 3247 34 a a DT cord-335975-m6lkrehi 3247 35 provincial provincial JJ cord-335975-m6lkrehi 3247 36 University University NNP cord-335975-m6lkrehi 3247 37 Hospital Hospital NNP cord-335975-m6lkrehi 3247 38 . . . cord-335975-m6lkrehi 3248 1 Patients patient NNS cord-335975-m6lkrehi 3248 2 and and CC cord-335975-m6lkrehi 3248 3 methods method NNS cord-335975-m6lkrehi 3248 4 : : : cord-335975-m6lkrehi 3248 5 A a DT cord-335975-m6lkrehi 3248 6 retrospective retrospective JJ cord-335975-m6lkrehi 3248 7 cohort cohort NN cord-335975-m6lkrehi 3248 8 study study NN cord-335975-m6lkrehi 3248 9 was be VBD cord-335975-m6lkrehi 3248 10 conducted conduct VBN cord-335975-m6lkrehi 3248 11 using use VBG cord-335975-m6lkrehi 3248 12 medical medical JJ cord-335975-m6lkrehi 3248 13 intensive intensive JJ cord-335975-m6lkrehi 3248 14 care care NN cord-335975-m6lkrehi 3248 15 unit unit NN cord-335975-m6lkrehi 3248 16 registry registry NN cord-335975-m6lkrehi 3248 17 for for IN cord-335975-m6lkrehi 3248 18 demographic demographic JJ cord-335975-m6lkrehi 3248 19 , , , cord-335975-m6lkrehi 3248 20 physiological physiological JJ cord-335975-m6lkrehi 3248 21 and and CC cord-335975-m6lkrehi 3248 22 diagnostic diagnostic JJ cord-335975-m6lkrehi 3248 23 data datum NNS cord-335975-m6lkrehi 3248 24 from from IN cord-335975-m6lkrehi 3248 25 January January NNP cord-335975-m6lkrehi 3248 26 2003 2003 CD cord-335975-m6lkrehi 3248 27 to to IN cord-335975-m6lkrehi 3248 28 December December NNP cord-335975-m6lkrehi 3248 29 2016 2016 CD cord-335975-m6lkrehi 3248 30 . . . cord-335975-m6lkrehi 3249 1 Characteristics characteristic NNS cord-335975-m6lkrehi 3249 2 and and CC cord-335975-m6lkrehi 3249 3 treatment treatment NN cord-335975-m6lkrehi 3249 4 intensity intensity NN cord-335975-m6lkrehi 3249 5 during during IN cord-335975-m6lkrehi 3249 6 medical medical JJ cord-335975-m6lkrehi 3249 7 ICU ICU NNP cord-335975-m6lkrehi 3249 8 stay stay NN cord-335975-m6lkrehi 3249 9 were be VBD cord-335975-m6lkrehi 3249 10 specified specify VBN cord-335975-m6lkrehi 3249 11 , , , cord-335975-m6lkrehi 3249 12 and and CC cord-335975-m6lkrehi 3249 13 short short JJ cord-335975-m6lkrehi 3249 14 term term NN cord-335975-m6lkrehi 3249 15 and and CC cord-335975-m6lkrehi 3249 16 long long JJ cord-335975-m6lkrehi 3249 17 term term NN cord-335975-m6lkrehi 3249 18 mortality mortality NN cord-335975-m6lkrehi 3249 19 were be VBD cord-335975-m6lkrehi 3249 20 also also RB cord-335975-m6lkrehi 3249 21 recorded record VBN cord-335975-m6lkrehi 3249 22 . . . cord-335975-m6lkrehi 3250 1 Results result NNS cord-335975-m6lkrehi 3250 2 : : : cord-335975-m6lkrehi 3251 1 A a DT cord-335975-m6lkrehi 3251 2 total total NN cord-335975-m6lkrehi 3251 3 of of IN cord-335975-m6lkrehi 3251 4 6608 6608 CD cord-335975-m6lkrehi 3251 5 admissions admission NNS cord-335975-m6lkrehi 3251 6 , , , cord-335975-m6lkrehi 3251 7 including include VBG cord-335975-m6lkrehi 3251 8 689 689 CD cord-335975-m6lkrehi 3251 9 octogenarians octogenarian NNS cord-335975-m6lkrehi 3251 10 and and CC cord-335975-m6lkrehi 3251 11 older old JJR cord-335975-m6lkrehi 3251 12 , , , cord-335975-m6lkrehi 3251 13 were be VBD cord-335975-m6lkrehi 3251 14 registered register VBN cord-335975-m6lkrehi 3251 15 during during IN cord-335975-m6lkrehi 3251 16 the the DT cord-335975-m6lkrehi 3251 17 period period NN cord-335975-m6lkrehi 3251 18 . . . cord-335975-m6lkrehi 3252 1 The the DT cord-335975-m6lkrehi 3252 2 proportion proportion NN cord-335975-m6lkrehi 3252 3 of of IN cord-335975-m6lkrehi 3252 4 very very RB cord-335975-m6lkrehi 3252 5 elderly elderly JJ cord-335975-m6lkrehi 3252 6 people people NNS cord-335975-m6lkrehi 3252 7 gradually gradually RB cord-335975-m6lkrehi 3252 8 increase increase VBP cord-335975-m6lkrehi 3252 9 from from IN cord-335975-m6lkrehi 3252 10 4 4 CD cord-335975-m6lkrehi 3252 11 to to TO cord-335975-m6lkrehi 3252 12 11 11 CD cord-335975-m6lkrehi 3252 13 % % NN cord-335975-m6lkrehi 3252 14 . . . cord-335975-m6lkrehi 3253 1 Intensity intensity NN cord-335975-m6lkrehi 3253 2 of of IN cord-335975-m6lkrehi 3253 3 treatment treatment NN cord-335975-m6lkrehi 3253 4 ( ( -LRB- cord-335975-m6lkrehi 3253 5 organ organ NN cord-335975-m6lkrehi 3253 6 support support NN cord-335975-m6lkrehi 3253 7 ) ) -RRB- cord-335975-m6lkrehi 3253 8 increased increase VBD cord-335975-m6lkrehi 3253 9 from from IN cord-335975-m6lkrehi 3253 10 1.14 1.14 CD cord-335975-m6lkrehi 3253 11 from from IN cord-335975-m6lkrehi 3253 12 1.31 1.31 CD cord-335975-m6lkrehi 3253 13 per per IN cord-335975-m6lkrehi 3253 14 patient patient NN cord-335975-m6lkrehi 3253 15 between between IN cord-335975-m6lkrehi 3253 16 the the DT cord-335975-m6lkrehi 3253 17 primary primary NN cord-335975-m6lkrehi 3253 18 and and CC cord-335975-m6lkrehi 3253 19 the the DT cord-335975-m6lkrehi 3253 20 second second JJ cord-335975-m6lkrehi 3253 21 part part NN cord-335975-m6lkrehi 3253 22 of of IN cord-335975-m6lkrehi 3253 23 the the DT cord-335975-m6lkrehi 3253 24 period period NN cord-335975-m6lkrehi 3253 25 , , , cord-335975-m6lkrehi 3253 26 notably notably RB cord-335975-m6lkrehi 3253 27 linked link VBN cord-335975-m6lkrehi 3253 28 to to IN cord-335975-m6lkrehi 3253 29 mechanical mechanical JJ cord-335975-m6lkrehi 3253 30 ventilation ventilation NN cord-335975-m6lkrehi 3253 31 ( ( -LRB- cord-335975-m6lkrehi 3253 32 56 56 CD cord-335975-m6lkrehi 3253 33 vs. vs. IN cord-335975-m6lkrehi 3253 34 66 66 CD cord-335975-m6lkrehi 3253 35 % % NN cord-335975-m6lkrehi 3253 36 , , , cord-335975-m6lkrehi 3253 37 p p NN cord-335975-m6lkrehi 3253 38 < < XX cord-335975-m6lkrehi 3253 39 0.01 0.01 CD cord-335975-m6lkrehi 3253 40 ) ) -RRB- cord-335975-m6lkrehi 3253 41 and and CC cord-335975-m6lkrehi 3253 42 vasopressor vasopressor NN cord-335975-m6lkrehi 3253 43 infusion infusion NN cord-335975-m6lkrehi 3253 44 ( ( -LRB- cord-335975-m6lkrehi 3253 45 35 35 CD cord-335975-m6lkrehi 3253 46 vs. vs. IN cord-335975-m6lkrehi 3253 47 46 46 CD cord-335975-m6lkrehi 3253 48 % % NN cord-335975-m6lkrehi 3253 49 , , , cord-335975-m6lkrehi 3253 50 p p NN cord-335975-m6lkrehi 3253 51 < < XX cord-335975-m6lkrehi 3253 52 0.01 0.01 CD cord-335975-m6lkrehi 3253 53 ) ) -RRB- cord-335975-m6lkrehi 3253 54 . . . cord-335975-m6lkrehi 3254 1 Even even RB cord-335975-m6lkrehi 3254 2 if if IN cord-335975-m6lkrehi 3254 3 severity severity NN cord-335975-m6lkrehi 3254 4 score score NN cord-335975-m6lkrehi 3254 5 increased increase VBD cord-335975-m6lkrehi 3254 6 ( ( -LRB- cord-335975-m6lkrehi 3254 7 SAPS sap NNS cord-335975-m6lkrehi 3254 8 2 2 CD cord-335975-m6lkrehi 3254 9 increase increase NN cord-335975-m6lkrehi 3254 10 from from IN cord-335975-m6lkrehi 3254 11 52.7 52.7 CD cord-335975-m6lkrehi 3254 12 to to IN cord-335975-m6lkrehi 3254 13 60.5 60.5 CD cord-335975-m6lkrehi 3254 14 , , , cord-335975-m6lkrehi 3254 15 p p NN cord-335975-m6lkrehi 3254 16 < < XX cord-335975-m6lkrehi 3254 17 0.01 0.01 CD cord-335975-m6lkrehi 3254 18 ) ) -RRB- cord-335975-m6lkrehi 3254 19 , , , cord-335975-m6lkrehi 3254 20 the the DT cord-335975-m6lkrehi 3254 21 ICU ICU NNP cord-335975-m6lkrehi 3254 22 mortality mortality NN cord-335975-m6lkrehi 3254 23 remains remain VBZ cord-335975-m6lkrehi 3254 24 constant constant JJ cord-335975-m6lkrehi 3254 25 ( ( -LRB- cord-335975-m6lkrehi 3254 26 34 34 CD cord-335975-m6lkrehi 3254 27 vs. vs. NN cord-335975-m6lkrehi 3254 28 32.8 32.8 CD cord-335975-m6lkrehi 3254 29 % % NN cord-335975-m6lkrehi 3254 30 ) ) -RRB- cord-335975-m6lkrehi 3254 31 . . . cord-335975-m6lkrehi 3255 1 However however RB cord-335975-m6lkrehi 3255 2 , , , cord-335975-m6lkrehi 3255 3 we -PRON- PRP cord-335975-m6lkrehi 3255 4 were be VBD cord-335975-m6lkrehi 3255 5 surprised surprised JJ cord-335975-m6lkrehi 3255 6 to to TO cord-335975-m6lkrehi 3255 7 observe observe VB cord-335975-m6lkrehi 3255 8 an an DT cord-335975-m6lkrehi 3255 9 increase increase NN cord-335975-m6lkrehi 3255 10 in in IN cord-335975-m6lkrehi 3255 11 1 1 CD cord-335975-m6lkrehi 3255 12 year year NN cord-335975-m6lkrehi 3255 13 mortality mortality NN cord-335975-m6lkrehi 3255 14 ( ( -LRB- cord-335975-m6lkrehi 3255 15 62 62 CD cord-335975-m6lkrehi 3255 16 to to TO cord-335975-m6lkrehi 3255 17 74 74 CD cord-335975-m6lkrehi 3255 18 % % NN cord-335975-m6lkrehi 3255 19 , , , cord-335975-m6lkrehi 3255 20 p p NN cord-335975-m6lkrehi 3255 21 < < XX cord-335975-m6lkrehi 3255 22 0.01 0.01 CD cord-335975-m6lkrehi 3255 23 ) ) -RRB- cord-335975-m6lkrehi 3255 24 . . . cord-335975-m6lkrehi 3256 1 Conclusion conclusion NN cord-335975-m6lkrehi 3256 2 : : : cord-335975-m6lkrehi 3257 1 Between between IN cord-335975-m6lkrehi 3257 2 2003 2003 CD cord-335975-m6lkrehi 3257 3 and and CC cord-335975-m6lkrehi 3257 4 2016 2016 CD cord-335975-m6lkrehi 3257 5 , , , cord-335975-m6lkrehi 3257 6 proportion proportion NN cord-335975-m6lkrehi 3257 7 of of IN cord-335975-m6lkrehi 3257 8 admission admission NN cord-335975-m6lkrehi 3257 9 of of IN cord-335975-m6lkrehi 3257 10 very very RB cord-335975-m6lkrehi 3257 11 elderly elderly JJ cord-335975-m6lkrehi 3257 12 people people NNS cord-335975-m6lkrehi 3257 13 has have VBZ cord-335975-m6lkrehi 3257 14 increased increase VBN cord-335975-m6lkrehi 3257 15 two two CD cord-335975-m6lkrehi 3257 16 fold fold NN cord-335975-m6lkrehi 3257 17 in in IN cord-335975-m6lkrehi 3257 18 our -PRON- PRP$ cord-335975-m6lkrehi 3257 19 ICU ICU NNP cord-335975-m6lkrehi 3257 20 . . . cord-335975-m6lkrehi 3258 1 Although although IN cord-335975-m6lkrehi 3258 2 treatment treatment NN cord-335975-m6lkrehi 3258 3 intensity intensity NN cord-335975-m6lkrehi 3258 4 increases increase VBZ cord-335975-m6lkrehi 3258 5 for for IN cord-335975-m6lkrehi 3258 6 more more RBR cord-335975-m6lkrehi 3258 7 severe severe JJ cord-335975-m6lkrehi 3258 8 patients patient NNS cord-335975-m6lkrehi 3258 9 , , , cord-335975-m6lkrehi 3258 10 ICU ICU NNP cord-335975-m6lkrehi 3258 11 mortality mortality NN cord-335975-m6lkrehi 3258 12 remains remain VBZ cord-335975-m6lkrehi 3258 13 the the DT cord-335975-m6lkrehi 3258 14 same same JJ cord-335975-m6lkrehi 3258 15 . . . cord-335975-m6lkrehi 3259 1 Nevertheless nevertheless RB cord-335975-m6lkrehi 3259 2 , , , cord-335975-m6lkrehi 3259 3 absence absence NN cord-335975-m6lkrehi 3259 4 of of IN cord-335975-m6lkrehi 3259 5 beneficial beneficial JJ cord-335975-m6lkrehi 3259 6 effect effect NN cord-335975-m6lkrehi 3259 7 after after IN cord-335975-m6lkrehi 3259 8 1 1 CD cord-335975-m6lkrehi 3259 9 year year NN cord-335975-m6lkrehi 3259 10 remains remain VBZ cord-335975-m6lkrehi 3259 11 questioning question VBG cord-335975-m6lkrehi 3259 12 . . . cord-335975-m6lkrehi 3260 1 Could Could MD cord-335975-m6lkrehi 3260 2 ICU ICU NNP cord-335975-m6lkrehi 3260 3 to to IN cord-335975-m6lkrehi 3260 4 ward ward NN cord-335975-m6lkrehi 3260 5 transfers transfer NNS cord-335975-m6lkrehi 3260 6 and and CC cord-335975-m6lkrehi 3260 7 care care VB cord-335975-m6lkrehi 3260 8 course course NN cord-335975-m6lkrehi 3260 9 after after IN cord-335975-m6lkrehi 3260 10 hospital hospital NN cord-335975-m6lkrehi 3260 11 be be VB cord-335975-m6lkrehi 3260 12 optimized optimize VBN cord-335975-m6lkrehi 3260 13 ? ? . cord-335975-m6lkrehi 3261 1 lived live VBD cord-335975-m6lkrehi 3261 2 alone alone JJ cord-335975-m6lkrehi 3261 3 at at IN cord-335975-m6lkrehi 3261 4 home home NN cord-335975-m6lkrehi 3261 5 , , , cord-335975-m6lkrehi 3261 6 40 40 CD cord-335975-m6lkrehi 3261 7 % % NN cord-335975-m6lkrehi 3261 8 in in IN cord-335975-m6lkrehi 3261 9 couple couple NN cord-335975-m6lkrehi 3261 10 or or CC cord-335975-m6lkrehi 3261 11 with with IN cord-335975-m6lkrehi 3261 12 ther ther NNP cord-335975-m6lkrehi 3261 13 family family NN cord-335975-m6lkrehi 3261 14 , , , cord-335975-m6lkrehi 3261 15 21 21 CD cord-335975-m6lkrehi 3261 16 ( ( -LRB- cord-335975-m6lkrehi 3261 17 9 9 CD cord-335975-m6lkrehi 3261 18 % % NN cord-335975-m6lkrehi 3261 19 ) ) -RRB- cord-335975-m6lkrehi 3261 20 in in IN cord-335975-m6lkrehi 3261 21 retirement retirement NN cord-335975-m6lkrehi 3261 22 home home NN cord-335975-m6lkrehi 3261 23 and and CC cord-335975-m6lkrehi 3261 24 16 16 CD cord-335975-m6lkrehi 3261 25 ( ( -LRB- cord-335975-m6lkrehi 3261 26 7 7 CD cord-335975-m6lkrehi 3261 27 % % NN cord-335975-m6lkrehi 3261 28 ) ) -RRB- cord-335975-m6lkrehi 3261 29 in in IN cord-335975-m6lkrehi 3261 30 nursing nursing NN cord-335975-m6lkrehi 3261 31 home home NN cord-335975-m6lkrehi 3261 32 . . . cord-335975-m6lkrehi 3262 1 40 40 CD cord-335975-m6lkrehi 3262 2 ( ( -LRB- cord-335975-m6lkrehi 3262 3 17 17 CD cord-335975-m6lkrehi 3262 4 % % NN cord-335975-m6lkrehi 3262 5 ) ) -RRB- cord-335975-m6lkrehi 3262 6 had have VBD cord-335975-m6lkrehi 3262 7 a a DT cord-335975-m6lkrehi 3262 8 simplified simplified JJ cord-335975-m6lkrehi 3262 9 ALD ALD NNP cord-335975-m6lkrehi 3262 10 score score NN cord-335975-m6lkrehi 3262 11 lower low JJR cord-335975-m6lkrehi 3262 12 than than IN cord-335975-m6lkrehi 3262 13 4 4 CD cord-335975-m6lkrehi 3262 14 indicating indicate VBG cord-335975-m6lkrehi 3262 15 good good JJ cord-335975-m6lkrehi 3262 16 functional functional JJ cord-335975-m6lkrehi 3262 17 independence independence NN cord-335975-m6lkrehi 3262 18 . . . cord-335975-m6lkrehi 3263 1 The the DT cord-335975-m6lkrehi 3263 2 more more RBR cord-335975-m6lkrehi 3263 3 frequent frequent JJ cord-335975-m6lkrehi 3263 4 diagnosis diagnosis NN cord-335975-m6lkrehi 3263 5 were be VBD cord-335975-m6lkrehi 3263 6 acute acute JJ cord-335975-m6lkrehi 3263 7 pulmonary pulmonary JJ cord-335975-m6lkrehi 3263 8 oedema oedema NN cord-335975-m6lkrehi 3263 9 and and CC cord-335975-m6lkrehi 3263 10 exacerbated exacerbate VBD cord-335975-m6lkrehi 3263 11 COPD COPD NNP cord-335975-m6lkrehi 3263 12 . . . cord-335975-m6lkrehi 3264 1 The the DT cord-335975-m6lkrehi 3264 2 mean mean JJ cord-335975-m6lkrehi 3264 3 simplified simplify VBD cord-335975-m6lkrehi 3264 4 acute acute JJ cord-335975-m6lkrehi 3264 5 physiology physiology NN cord-335975-m6lkrehi 3264 6 score score NN cord-335975-m6lkrehi 3264 7 ( ( -LRB- cord-335975-m6lkrehi 3264 8 SAPS SAPS NNP cord-335975-m6lkrehi 3264 9 II II NNP cord-335975-m6lkrehi 3264 10 ) ) -RRB- cord-335975-m6lkrehi 3264 11 was be VBD cord-335975-m6lkrehi 3264 12 53 53 CD cord-335975-m6lkrehi 3264 13 ± ± CD cord-335975-m6lkrehi 3264 14 21 21 CD cord-335975-m6lkrehi 3264 15 . . . cord-335975-m6lkrehi 3265 1 The the DT cord-335975-m6lkrehi 3265 2 treatment treatment NN cord-335975-m6lkrehi 3265 3 were be VBD cord-335975-m6lkrehi 3265 4 were be VBD cord-335975-m6lkrehi 3265 5 invasive invasive JJ cord-335975-m6lkrehi 3265 6 mechanical mechanical JJ cord-335975-m6lkrehi 3265 7 ventilation ventilation NN cord-335975-m6lkrehi 3265 8 84 84 CD cord-335975-m6lkrehi 3265 9 ( ( -LRB- cord-335975-m6lkrehi 3265 10 36 36 CD cord-335975-m6lkrehi 3265 11 % % NN cord-335975-m6lkrehi 3265 12 ) ) -RRB- cord-335975-m6lkrehi 3265 13 , , , cord-335975-m6lkrehi 3265 14 only only RB cord-335975-m6lkrehi 3265 15 with with IN cord-335975-m6lkrehi 3265 16 noninvasive noninvasive JJ cord-335975-m6lkrehi 3265 17 ventilation ventilation NN cord-335975-m6lkrehi 3265 18 50 50 CD cord-335975-m6lkrehi 3265 19 ( ( -LRB- cord-335975-m6lkrehi 3265 20 21 21 CD cord-335975-m6lkrehi 3265 21 % % NN cord-335975-m6lkrehi 3265 22 ) ) -RRB- cord-335975-m6lkrehi 3265 23 , , , cord-335975-m6lkrehi 3265 24 vasopressor vasopressor NN cord-335975-m6lkrehi 3265 25 agents agent NNS cord-335975-m6lkrehi 3265 26 79 79 CD cord-335975-m6lkrehi 3265 27 ( ( -LRB- cord-335975-m6lkrehi 3265 28 33 33 CD cord-335975-m6lkrehi 3265 29 % % NN cord-335975-m6lkrehi 3265 30 ) ) -RRB- cord-335975-m6lkrehi 3265 31 and and CC cord-335975-m6lkrehi 3265 32 4 4 CD cord-335975-m6lkrehi 3265 33 ( ( -LRB- cord-335975-m6lkrehi 3265 34 2 2 CD cord-335975-m6lkrehi 3265 35 % % NN cord-335975-m6lkrehi 3265 36 ) ) -RRB- cord-335975-m6lkrehi 3265 37 with with IN cord-335975-m6lkrehi 3265 38 renal renal JJ cord-335975-m6lkrehi 3265 39 replacement replacement NN cord-335975-m6lkrehi 3265 40 therapy therapy NN cord-335975-m6lkrehi 3265 41 . . . cord-335975-m6lkrehi 3266 1 The the DT cord-335975-m6lkrehi 3266 2 average average JJ cord-335975-m6lkrehi 3266 3 length length NN cord-335975-m6lkrehi 3266 4 of of IN cord-335975-m6lkrehi 3266 5 stay stay NN cord-335975-m6lkrehi 3266 6 was be VBD cord-335975-m6lkrehi 3266 7 5.9 5.9 CD cord-335975-m6lkrehi 3266 8 ± ± CD cord-335975-m6lkrehi 3266 9 6.1 6.1 CD cord-335975-m6lkrehi 3266 10 days day NNS cord-335975-m6lkrehi 3266 11 . . . cord-335975-m6lkrehi 3267 1 After after IN cord-335975-m6lkrehi 3267 2 adjustment adjustment NN cord-335975-m6lkrehi 3267 3 on on IN cord-335975-m6lkrehi 3267 4 SAP SAP NNP cord-335975-m6lkrehi 3267 5 - - HYPH cord-335975-m6lkrehi 3267 6 SII SII NNP cord-335975-m6lkrehi 3267 7 ( ( -LRB- cord-335975-m6lkrehi 3267 8 without without IN cord-335975-m6lkrehi 3267 9 age age NN cord-335975-m6lkrehi 3267 10 ) ) -RRB- cord-335975-m6lkrehi 3267 11 , , , cord-335975-m6lkrehi 3267 12 those those DT cord-335975-m6lkrehi 3267 13 invasive invasive JJ cord-335975-m6lkrehi 3267 14 treatments treatment NNS cord-335975-m6lkrehi 3267 15 were be VBD cord-335975-m6lkrehi 3267 16 not not RB cord-335975-m6lkrehi 3267 17 associated associate VBN cord-335975-m6lkrehi 3267 18 with with IN cord-335975-m6lkrehi 3267 19 mortality mortality NN cord-335975-m6lkrehi 3267 20 no no DT cord-335975-m6lkrehi 3267 21 more more JJR cord-335975-m6lkrehi 3267 22 than than IN cord-335975-m6lkrehi 3267 23 age age NN cord-335975-m6lkrehi 3267 24 . . . cord-335975-m6lkrehi 3268 1 Global global JJ cord-335975-m6lkrehi 3268 2 mortality mortality NN cord-335975-m6lkrehi 3268 3 rate rate NN cord-335975-m6lkrehi 3268 4 was be VBD cord-335975-m6lkrehi 3268 5 28 28 CD cord-335975-m6lkrehi 3268 6 % % NN cord-335975-m6lkrehi 3268 7 . . . cord-335975-m6lkrehi 3269 1 53 53 CD cord-335975-m6lkrehi 3269 2 ( ( -LRB- cord-335975-m6lkrehi 3269 3 22 22 CD cord-335975-m6lkrehi 3269 4 % % NN cord-335975-m6lkrehi 3269 5 ) ) -RRB- cord-335975-m6lkrehi 3269 6 were be VBD cord-335975-m6lkrehi 3269 7 subject subject JJ cord-335975-m6lkrehi 3269 8 of of IN cord-335975-m6lkrehi 3269 9 a a DT cord-335975-m6lkrehi 3269 10 procedure procedure NN cord-335975-m6lkrehi 3269 11 for for IN cord-335975-m6lkrehi 3269 12 limiting limit VBG cord-335975-m6lkrehi 3269 13 therapeutics therapeutic NNS cord-335975-m6lkrehi 3269 14 , , , cord-335975-m6lkrehi 3269 15 among among IN cord-335975-m6lkrehi 3269 16 which which WDT cord-335975-m6lkrehi 3269 17 35 35 CD cord-335975-m6lkrehi 3269 18 ( ( -LRB- cord-335975-m6lkrehi 3269 19 66 66 CD cord-335975-m6lkrehi 3269 20 % % NN cord-335975-m6lkrehi 3269 21 ) ) -RRB- cord-335975-m6lkrehi 3269 22 died die VBD cord-335975-m6lkrehi 3269 23 in in IN cord-335975-m6lkrehi 3269 24 the the DT cord-335975-m6lkrehi 3269 25 unit unit NN cord-335975-m6lkrehi 3269 26 versus versus IN cord-335975-m6lkrehi 3269 27 17 17 CD cord-335975-m6lkrehi 3269 28 % % NN cord-335975-m6lkrehi 3269 29 for for IN cord-335975-m6lkrehi 3269 30 the the DT cord-335975-m6lkrehi 3269 31 other other JJ cord-335975-m6lkrehi 3269 32 patients patient NNS cord-335975-m6lkrehi 3269 33 . . . cord-335975-m6lkrehi 3270 1 The the DT cord-335975-m6lkrehi 3270 2 decision decision NN cord-335975-m6lkrehi 3270 3 of of IN cord-335975-m6lkrehi 3270 4 therapeutic therapeutic JJ cord-335975-m6lkrehi 3270 5 limitation limitation NN cord-335975-m6lkrehi 3270 6 was be VBD cord-335975-m6lkrehi 3270 7 associated associate VBN cord-335975-m6lkrehi 3270 8 with with IN cord-335975-m6lkrehi 3270 9 severity severity NN cord-335975-m6lkrehi 3270 10 of of IN cord-335975-m6lkrehi 3270 11 illness illness NN cord-335975-m6lkrehi 3270 12 as as IN cord-335975-m6lkrehi 3270 13 measured measure VBN cord-335975-m6lkrehi 3270 14 by by IN cord-335975-m6lkrehi 3270 15 the the DT cord-335975-m6lkrehi 3270 16 SAPSII SAPSII NNP cord-335975-m6lkrehi 3270 17 ( ( -LRB- cord-335975-m6lkrehi 3270 18 p p NN cord-335975-m6lkrehi 3270 19 = = SYM cord-335975-m6lkrehi 3270 20 0.01 0.01 CD cord-335975-m6lkrehi 3270 21 ) ) -RRB- cord-335975-m6lkrehi 3270 22 but but CC cord-335975-m6lkrehi 3270 23 not not RB cord-335975-m6lkrehi 3270 24 with with IN cord-335975-m6lkrehi 3270 25 age age NN cord-335975-m6lkrehi 3270 26 . . . cord-335975-m6lkrehi 3271 1 Frequency frequency NN cord-335975-m6lkrehi 3271 2 of of IN cord-335975-m6lkrehi 3271 3 therapeutic therapeutic JJ cord-335975-m6lkrehi 3271 4 limitation limitation NN cord-335975-m6lkrehi 3271 5 were be VBD cord-335975-m6lkrehi 3271 6 similar similar JJ cord-335975-m6lkrehi 3271 7 in in IN cord-335975-m6lkrehi 3271 8 ICU ICU NNP cord-335975-m6lkrehi 3271 9 and and CC cord-335975-m6lkrehi 3271 10 intermediate intermediate JJ cord-335975-m6lkrehi 3271 11 care care NN cord-335975-m6lkrehi 3271 12 units unit NNS cord-335975-m6lkrehi 3271 13 . . . cord-335975-m6lkrehi 3272 1 The the DT cord-335975-m6lkrehi 3272 2 mortality mortality NN cord-335975-m6lkrehi 3272 3 rate rate NN cord-335975-m6lkrehi 3272 4 is be VBZ cord-335975-m6lkrehi 3272 5 lower low JJR cord-335975-m6lkrehi 3272 6 than than IN cord-335975-m6lkrehi 3272 7 the the DT cord-335975-m6lkrehi 3272 8 older old JJR cord-335975-m6lkrehi 3272 9 studies study NNS cord-335975-m6lkrehi 3272 10 ( ( -LRB- cord-335975-m6lkrehi 3272 11 S S NNP cord-335975-m6lkrehi 3272 12 de de NNP cord-335975-m6lkrehi 3272 13 Rooij Rooij NNP cord-335975-m6lkrehi 3272 14 2005 2005 CD cord-335975-m6lkrehi 3272 15 - - SYM cord-335975-m6lkrehi 3272 16 38 38 CD cord-335975-m6lkrehi 3272 17 % % NN cord-335975-m6lkrehi 3272 18 ) ) -RRB- cord-335975-m6lkrehi 3272 19 . . . cord-335975-m6lkrehi 3273 1 Unlike unlike IN cord-335975-m6lkrehi 3273 2 the the DT cord-335975-m6lkrehi 3273 3 study study NN cord-335975-m6lkrehi 3273 4 of of IN cord-335975-m6lkrehi 3273 5 P. P. NNP cord-335975-m6lkrehi 3273 6 Biston Biston NNP cord-335975-m6lkrehi 3273 7 ( ( -LRB- cord-335975-m6lkrehi 3273 8 2013 2013 CD cord-335975-m6lkrehi 3273 9 ) ) -RRB- cord-335975-m6lkrehi 3273 10 which which WDT cord-335975-m6lkrehi 3273 11 covers cover VBZ cord-335975-m6lkrehi 3273 12 only only RB cord-335975-m6lkrehi 3273 13 the the DT cord-335975-m6lkrehi 3273 14 most most RBS cord-335975-m6lkrehi 3273 15 serious serious JJ cord-335975-m6lkrehi 3273 16 cases case NNS cord-335975-m6lkrehi 3273 17 , , , cord-335975-m6lkrehi 3273 18 the the DT cord-335975-m6lkrehi 3273 19 mortality mortality NN cord-335975-m6lkrehi 3273 20 for for IN cord-335975-m6lkrehi 3273 21 any any DT cord-335975-m6lkrehi 3273 22 type type NN cord-335975-m6lkrehi 3273 23 of of IN cord-335975-m6lkrehi 3273 24 gravity gravity NN cord-335975-m6lkrehi 3273 25 remains remain VBZ cord-335975-m6lkrehi 3273 26 reasonable reasonable JJ cord-335975-m6lkrehi 3273 27 . . . cord-335975-m6lkrehi 3274 1 The the DT cord-335975-m6lkrehi 3274 2 procedure procedure NN cord-335975-m6lkrehi 3274 3 for for IN cord-335975-m6lkrehi 3274 4 limiting limit VBG cord-335975-m6lkrehi 3274 5 care care NN cord-335975-m6lkrehi 3274 6 were be VBD cord-335975-m6lkrehi 3274 7 frequent frequent JJ cord-335975-m6lkrehi 3274 8 especially especially RB cord-335975-m6lkrehi 3274 9 for for IN cord-335975-m6lkrehi 3274 10 the the DT cord-335975-m6lkrehi 3274 11 most most RBS cord-335975-m6lkrehi 3274 12 severe severe JJ cord-335975-m6lkrehi 3274 13 pathologies pathology NNS cord-335975-m6lkrehi 3274 14 but but CC cord-335975-m6lkrehi 3274 15 all all PDT cord-335975-m6lkrehi 3274 16 the the DT cord-335975-m6lkrehi 3274 17 patients patient NNS cord-335975-m6lkrehi 3274 18 who who WP cord-335975-m6lkrehi 3274 19 a a DT cord-335975-m6lkrehi 3274 20 decision decision NN cord-335975-m6lkrehi 3274 21 of of IN cord-335975-m6lkrehi 3274 22 limiting limit VBG cord-335975-m6lkrehi 3274 23 care care NN cord-335975-m6lkrehi 3274 24 were be VBD cord-335975-m6lkrehi 3274 25 stated state VBN cord-335975-m6lkrehi 3274 26 were be VBD cord-335975-m6lkrehi 3274 27 not not RB cord-335975-m6lkrehi 3274 28 dead dead JJ cord-335975-m6lkrehi 3274 29 . . . cord-335975-m6lkrehi 3275 1 The the DT cord-335975-m6lkrehi 3275 2 patients patient NNS cord-335975-m6lkrehi 3275 3 over over IN cord-335975-m6lkrehi 3275 4 85 85 CD cord-335975-m6lkrehi 3275 5 years year NNS cord-335975-m6lkrehi 3275 6 old old JJ cord-335975-m6lkrehi 3275 7 admit admit VBP cord-335975-m6lkrehi 3275 8 in in IN cord-335975-m6lkrehi 3275 9 french french JJ cord-335975-m6lkrehi 3275 10 ICU ICU NNP cord-335975-m6lkrehi 3275 11 are be VBP cord-335975-m6lkrehi 3275 12 very very RB cord-335975-m6lkrehi 3275 13 chosen choose VBN cord-335975-m6lkrehi 3275 14 . . . cord-335975-m6lkrehi 3276 1 Any any DT cord-335975-m6lkrehi 3276 2 major major JJ cord-335975-m6lkrehi 3276 3 treatment treatment NN cord-335975-m6lkrehi 3276 4 appear appear VBP cord-335975-m6lkrehi 3276 5 to to TO cord-335975-m6lkrehi 3276 6 enhance enhance VB cord-335975-m6lkrehi 3276 7 mortality mortality NN cord-335975-m6lkrehi 3276 8 . . . cord-335975-m6lkrehi 3277 1 Introduction introduction NN cord-335975-m6lkrehi 3277 2 : : : cord-335975-m6lkrehi 3278 1 Due due IN cord-335975-m6lkrehi 3278 2 to to IN cord-335975-m6lkrehi 3278 3 advancements advancement NNS cord-335975-m6lkrehi 3278 4 in in IN cord-335975-m6lkrehi 3278 5 medical medical JJ cord-335975-m6lkrehi 3278 6 technology technology NN cord-335975-m6lkrehi 3278 7 and and CC cord-335975-m6lkrehi 3278 8 management management NN cord-335975-m6lkrehi 3278 9 of of IN cord-335975-m6lkrehi 3278 10 illnesses illness NNS cord-335975-m6lkrehi 3278 11 , , , cord-335975-m6lkrehi 3278 12 an an DT cord-335975-m6lkrehi 3278 13 increasing increase VBG cord-335975-m6lkrehi 3278 14 proportion proportion NN cord-335975-m6lkrehi 3278 15 of of IN cord-335975-m6lkrehi 3278 16 critically critically RB cord-335975-m6lkrehi 3278 17 ill ill JJ cord-335975-m6lkrehi 3278 18 patients patient NNS cord-335975-m6lkrehi 3278 19 are be VBP cord-335975-m6lkrehi 3278 20 elderly elderly JJ cord-335975-m6lkrehi 3278 21 . . . cord-335975-m6lkrehi 3279 1 Few few JJ cord-335975-m6lkrehi 3279 2 information information NN cord-335975-m6lkrehi 3279 3 is be VBZ cord-335975-m6lkrehi 3279 4 available available JJ cord-335975-m6lkrehi 3279 5 on on IN cord-335975-m6lkrehi 3279 6 the the DT cord-335975-m6lkrehi 3279 7 prognosis prognosis NN cord-335975-m6lkrehi 3279 8 of of IN cord-335975-m6lkrehi 3279 9 these these DT cord-335975-m6lkrehi 3279 10 patients patient NNS cord-335975-m6lkrehi 3279 11 after after IN cord-335975-m6lkrehi 3279 12 ICU ICU NNP cord-335975-m6lkrehi 3279 13 discharge discharge NN cord-335975-m6lkrehi 3279 14 . . . cord-335975-m6lkrehi 3280 1 The the DT cord-335975-m6lkrehi 3280 2 aim aim NN cord-335975-m6lkrehi 3280 3 of of IN cord-335975-m6lkrehi 3280 4 this this DT cord-335975-m6lkrehi 3280 5 study study NN cord-335975-m6lkrehi 3280 6 was be VBD cord-335975-m6lkrehi 3280 7 to to TO cord-335975-m6lkrehi 3280 8 analyze analyze VB cord-335975-m6lkrehi 3280 9 the the DT cord-335975-m6lkrehi 3280 10 clinical clinical JJ cord-335975-m6lkrehi 3280 11 characteristics characteristic NNS cord-335975-m6lkrehi 3280 12 and and CC cord-335975-m6lkrehi 3280 13 long long JJ cord-335975-m6lkrehi 3280 14 - - HYPH cord-335975-m6lkrehi 3280 15 term term NN cord-335975-m6lkrehi 3280 16 outcomes outcome NNS cord-335975-m6lkrehi 3280 17 of of IN cord-335975-m6lkrehi 3280 18 elderly elderly JJ cord-335975-m6lkrehi 3280 19 admitted admit VBN cord-335975-m6lkrehi 3280 20 to to IN cord-335975-m6lkrehi 3280 21 ICU ICU NNP cord-335975-m6lkrehi 3280 22 . . . cord-335975-m6lkrehi 3281 1 Patients patient NNS cord-335975-m6lkrehi 3281 2 and and CC cord-335975-m6lkrehi 3281 3 methods method NNS cord-335975-m6lkrehi 3281 4 : : : cord-335975-m6lkrehi 3281 5 Monocentric monocentric JJ cord-335975-m6lkrehi 3281 6 , , , cord-335975-m6lkrehi 3281 7 observational observational JJ cord-335975-m6lkrehi 3281 8 prospective prospective JJ cord-335975-m6lkrehi 3281 9 study study NN cord-335975-m6lkrehi 3281 10 was be VBD cord-335975-m6lkrehi 3281 11 performed perform VBN cord-335975-m6lkrehi 3281 12 . . . cord-335975-m6lkrehi 3282 1 All all DT cord-335975-m6lkrehi 3282 2 elderly elderly JJ cord-335975-m6lkrehi 3282 3 survivors survivor NNS cord-335975-m6lkrehi 3282 4 ( ( -LRB- cord-335975-m6lkrehi 3282 5 aged aged JJ cord-335975-m6lkrehi 3282 6 ≥ ≥ CD cord-335975-m6lkrehi 3282 7 65 65 CD cord-335975-m6lkrehi 3282 8 years year NNS cord-335975-m6lkrehi 3282 9 ) ) -RRB- cord-335975-m6lkrehi 3282 10 after after IN cord-335975-m6lkrehi 3282 11 an an DT cord-335975-m6lkrehi 3282 12 ICU ICU NNP cord-335975-m6lkrehi 3282 13 stay stay NN cord-335975-m6lkrehi 3282 14 in in IN cord-335975-m6lkrehi 3282 15 a a DT cord-335975-m6lkrehi 3282 16 medical medical JJ cord-335975-m6lkrehi 3282 17 Tunisian tunisian JJ cord-335975-m6lkrehi 3282 18 ICU ICU NNP cord-335975-m6lkrehi 3282 19 between between IN cord-335975-m6lkrehi 3282 20 January January NNP cord-335975-m6lkrehi 3282 21 2014 2014 CD cord-335975-m6lkrehi 3282 22 and and CC cord-335975-m6lkrehi 3282 23 December December NNP cord-335975-m6lkrehi 3282 24 2015 2015 CD cord-335975-m6lkrehi 3282 25 were be VBD cord-335975-m6lkrehi 3282 26 included include VBN cord-335975-m6lkrehi 3282 27 . . . cord-335975-m6lkrehi 3283 1 Data datum NNS cord-335975-m6lkrehi 3283 2 collected collect VBN cord-335975-m6lkrehi 3283 3 were be VBD cord-335975-m6lkrehi 3283 4 : : : cord-335975-m6lkrehi 3283 5 clinical clinical JJ cord-335975-m6lkrehi 3283 6 features feature NNS cord-335975-m6lkrehi 3283 7 at at IN cord-335975-m6lkrehi 3283 8 admission admission NN cord-335975-m6lkrehi 3283 9 , , , cord-335975-m6lkrehi 3283 10 acute acute JJ cord-335975-m6lkrehi 3283 11 management management NN cord-335975-m6lkrehi 3283 12 procedures procedure NNS cord-335975-m6lkrehi 3283 13 , , , cord-335975-m6lkrehi 3283 14 functional functional JJ cord-335975-m6lkrehi 3283 15 characteristics characteristic NNS cord-335975-m6lkrehi 3283 16 and and CC cord-335975-m6lkrehi 3283 17 vital vital JJ cord-335975-m6lkrehi 3283 18 parameters parameter NNS cord-335975-m6lkrehi 3283 19 ( ( -LRB- cord-335975-m6lkrehi 3283 20 Blood blood NN cord-335975-m6lkrehi 3283 21 Pressure pressure NN cord-335975-m6lkrehi 3283 22 , , , cord-335975-m6lkrehi 3283 23 Heart heart NN cord-335975-m6lkrehi 3283 24 Rate rate NN cord-335975-m6lkrehi 3283 25 , , , cord-335975-m6lkrehi 3283 26 ABG ABG NNP cord-335975-m6lkrehi 3283 27 's 's POS cord-335975-m6lkrehi 3283 28 ) ) -RRB- cord-335975-m6lkrehi 3283 29 at at IN cord-335975-m6lkrehi 3283 30 ICU ICU NNP cord-335975-m6lkrehi 3283 31 discharge discharge NN cord-335975-m6lkrehi 3283 32 . . . cord-335975-m6lkrehi 3284 1 Patients patient NNS cord-335975-m6lkrehi 3284 2 were be VBD cord-335975-m6lkrehi 3284 3 followed follow VBN cord-335975-m6lkrehi 3284 4 during during IN cord-335975-m6lkrehi 3284 5 1 1 CD cord-335975-m6lkrehi 3284 6 year year NN cord-335975-m6lkrehi 3284 7 via via IN cord-335975-m6lkrehi 3284 8 phone phone NN cord-335975-m6lkrehi 3284 9 calls call NNS cord-335975-m6lkrehi 3284 10 . . . cord-335975-m6lkrehi 3285 1 A a DT cord-335975-m6lkrehi 3285 2 multivariate multivariate JJ cord-335975-m6lkrehi 3285 3 regression regression NN cord-335975-m6lkrehi 3285 4 analysis analysis NN cord-335975-m6lkrehi 3285 5 was be VBD cord-335975-m6lkrehi 3285 6 used use VBN cord-335975-m6lkrehi 3285 7 to to TO cord-335975-m6lkrehi 3285 8 identify identify VB cord-335975-m6lkrehi 3285 9 risk risk NN cord-335975-m6lkrehi 3285 10 factors factor NNS cord-335975-m6lkrehi 3285 11 for for IN cord-335975-m6lkrehi 3285 12 one one CD cord-335975-m6lkrehi 3285 13 - - HYPH cord-335975-m6lkrehi 3285 14 year year NN cord-335975-m6lkrehi 3285 15 mortality mortality NN cord-335975-m6lkrehi 3285 16 . . . cord-335975-m6lkrehi 3286 1 Results result NNS cord-335975-m6lkrehi 3286 2 : : : cord-335975-m6lkrehi 3287 1 During during IN cord-335975-m6lkrehi 3287 2 the the DT cord-335975-m6lkrehi 3287 3 two two CD cord-335975-m6lkrehi 3287 4 - - HYPH cord-335975-m6lkrehi 3287 5 years year NNS cord-335975-m6lkrehi 3287 6 study study NN cord-335975-m6lkrehi 3287 7 period period NN cord-335975-m6lkrehi 3287 8 , , , cord-335975-m6lkrehi 3287 9 102 102 CD cord-335975-m6lkrehi 3287 10 elderly elderly JJ cord-335975-m6lkrehi 3287 11 patients patient NNS cord-335975-m6lkrehi 3287 12 were be VBD cord-335975-m6lkrehi 3287 13 discharged discharge VBN cord-335975-m6lkrehi 3287 14 alive alive JJ cord-335975-m6lkrehi 3287 15 . . . cord-335975-m6lkrehi 3288 1 60 60 CD cord-335975-m6lkrehi 3288 2 ( ( -LRB- cord-335975-m6lkrehi 3288 3 58.8 58.8 CD cord-335975-m6lkrehi 3288 4 % % NN cord-335975-m6lkrehi 3288 5 ) ) -RRB- cord-335975-m6lkrehi 3288 6 were be VBD cord-335975-m6lkrehi 3288 7 male male JJ cord-335975-m6lkrehi 3288 8 . . . cord-335975-m6lkrehi 3289 1 Clinical clinical JJ cord-335975-m6lkrehi 3289 2 features feature NNS cord-335975-m6lkrehi 3289 3 of of IN cord-335975-m6lkrehi 3289 4 elderly elderly JJ cord-335975-m6lkrehi 3289 5 survivors survivor NNS cord-335975-m6lkrehi 3289 6 were be VBD cord-335975-m6lkrehi 3289 7 : : : cord-335975-m6lkrehi 3289 8 Mean mean JJ cord-335975-m6lkrehi 3289 9 age age NN cord-335975-m6lkrehi 3289 10 , , , cord-335975-m6lkrehi 3289 11 74.9 74.9 CD cord-335975-m6lkrehi 3289 12 ± ± CD cord-335975-m6lkrehi 3289 13 6.54 6.54 CD cord-335975-m6lkrehi 3289 14 years year NNS cord-335975-m6lkrehi 3289 15 , , , cord-335975-m6lkrehi 3289 16 median median NN cord-335975-m6lkrehi 3289 17 of of IN cord-335975-m6lkrehi 3289 18 Charlson Charlson NNP cord-335975-m6lkrehi 3289 19 index index NN cord-335975-m6lkrehi 3289 20 , , , cord-335975-m6lkrehi 3290 1 2 2 LS cord-335975-m6lkrehi 3290 2 [ [ -LRB- cord-335975-m6lkrehi 3290 3 0 0 CD cord-335975-m6lkrehi 3290 4 - - SYM cord-335975-m6lkrehi 3290 5 7 7 CD cord-335975-m6lkrehi 3290 6 ] ] -RRB- cord-335975-m6lkrehi 3290 7 , , , cord-335975-m6lkrehi 3290 8 Chronic chronic JJ cord-335975-m6lkrehi 3290 9 respiratory respiratory JJ cord-335975-m6lkrehi 3290 10 disease disease NN cord-335975-m6lkrehi 3290 11 , , , cord-335975-m6lkrehi 3290 12 70 70 CD cord-335975-m6lkrehi 3290 13 ( ( -LRB- cord-335975-m6lkrehi 3290 14 68.6 68.6 CD cord-335975-m6lkrehi 3290 15 % % NN cord-335975-m6lkrehi 3290 16 ) ) -RRB- cord-335975-m6lkrehi 3290 17 , , , cord-335975-m6lkrehi 3290 18 hypertension hypertension NN cord-335975-m6lkrehi 3290 19 , , , cord-335975-m6lkrehi 3290 20 46 46 CD cord-335975-m6lkrehi 3290 21 ( ( -LRB- cord-335975-m6lkrehi 3290 22 45.1 45.1 CD cord-335975-m6lkrehi 3290 23 % % NN cord-335975-m6lkrehi 3290 24 ) ) -RRB- cord-335975-m6lkrehi 3290 25 and and CC cord-335975-m6lkrehi 3290 26 diabetes diabete VBZ cord-335975-m6lkrehi 3290 27 39 39 CD cord-335975-m6lkrehi 3290 28 ( ( -LRB- cord-335975-m6lkrehi 3290 29 38.2 38.2 CD cord-335975-m6lkrehi 3290 30 % % NN cord-335975-m6lkrehi 3290 31 ) ) -RRB- cord-335975-m6lkrehi 3290 32 . . . cord-335975-m6lkrehi 3291 1 The the DT cord-335975-m6lkrehi 3291 2 most most RBS cord-335975-m6lkrehi 3291 3 common common JJ cord-335975-m6lkrehi 3291 4 reason reason NN cord-335975-m6lkrehi 3291 5 for for IN cord-335975-m6lkrehi 3291 6 admission admission NN cord-335975-m6lkrehi 3291 7 was be VBD cord-335975-m6lkrehi 3291 8 acute acute JJ cord-335975-m6lkrehi 3291 9 respiratory respiratory JJ cord-335975-m6lkrehi 3291 10 failure failure NN cord-335975-m6lkrehi 3291 11 in in IN cord-335975-m6lkrehi 3291 12 80 80 CD cord-335975-m6lkrehi 3291 13 ( ( -LRB- cord-335975-m6lkrehi 3291 14 78.43 78.43 CD cord-335975-m6lkrehi 3291 15 % % NN cord-335975-m6lkrehi 3291 16 ) ) -RRB- cord-335975-m6lkrehi 3291 17 patients patient NNS cord-335975-m6lkrehi 3291 18 and and CC cord-335975-m6lkrehi 3291 19 mean mean VB cord-335975-m6lkrehi 3291 20 SAPS SAPS NNP cord-335975-m6lkrehi 3291 21 II II NNP cord-335975-m6lkrehi 3291 22 was be VBD cord-335975-m6lkrehi 3291 23 34.9 34.9 CD cord-335975-m6lkrehi 3291 24 ± ± CD cord-335975-m6lkrehi 3291 25 9.7 9.7 CD cord-335975-m6lkrehi 3291 26 . . . cord-335975-m6lkrehi 3292 1 45 45 CD cord-335975-m6lkrehi 3292 2 ( ( -LRB- cord-335975-m6lkrehi 3292 3 44.1 44.1 CD cord-335975-m6lkrehi 3292 4 % % NN cord-335975-m6lkrehi 3292 5 ) ) -RRB- cord-335975-m6lkrehi 3292 6 patients patient NNS cord-335975-m6lkrehi 3292 7 required require VBD cord-335975-m6lkrehi 3292 8 invasive invasive JJ cord-335975-m6lkrehi 3292 9 ventilatory ventilatory JJ cord-335975-m6lkrehi 3292 10 support support NN cord-335975-m6lkrehi 3292 11 , , , cord-335975-m6lkrehi 3292 12 43 43 CD cord-335975-m6lkrehi 3292 13 ( ( -LRB- cord-335975-m6lkrehi 3292 14 42.2 42.2 CD cord-335975-m6lkrehi 3292 15 % % NN cord-335975-m6lkrehi 3292 16 ) ) -RRB- cord-335975-m6lkrehi 3292 17 vasoactive vasoactive JJ cord-335975-m6lkrehi 3292 18 drugs drug NNS cord-335975-m6lkrehi 3292 19 and and CC cord-335975-m6lkrehi 3292 20 3 3 CD cord-335975-m6lkrehi 3292 21 ( ( -LRB- cord-335975-m6lkrehi 3292 22 2.9 2.9 CD cord-335975-m6lkrehi 3292 23 % % NN cord-335975-m6lkrehi 3292 24 ) ) -RRB- cord-335975-m6lkrehi 3292 25 received receive VBD cord-335975-m6lkrehi 3292 26 renal renal JJ cord-335975-m6lkrehi 3292 27 replacement replacement NN cord-335975-m6lkrehi 3292 28 therapy therapy NN cord-335975-m6lkrehi 3292 29 . . . cord-335975-m6lkrehi 3293 1 The the DT cord-335975-m6lkrehi 3293 2 median median NN cord-335975-m6lkrehi 3293 3 of of IN cord-335975-m6lkrehi 3293 4 ICU ICU NNP cord-335975-m6lkrehi 3293 5 length length NN cord-335975-m6lkrehi 3293 6 of of IN cord-335975-m6lkrehi 3293 7 stay stay NN cord-335975-m6lkrehi 3293 8 was be VBD cord-335975-m6lkrehi 3293 9 6 6 CD cord-335975-m6lkrehi 3293 10 days day NNS cord-335975-m6lkrehi 3293 11 . . . cord-335975-m6lkrehi 3294 1 The the DT cord-335975-m6lkrehi 3294 2 follow follow NN cord-335975-m6lkrehi 3294 3 up up RP cord-335975-m6lkrehi 3294 4 was be VBD cord-335975-m6lkrehi 3294 5 possible possible JJ cord-335975-m6lkrehi 3294 6 for for IN cord-335975-m6lkrehi 3294 7 80 80 CD cord-335975-m6lkrehi 3294 8 ( ( -LRB- cord-335975-m6lkrehi 3294 9 78.4 78.4 CD cord-335975-m6lkrehi 3294 10 % % NN cord-335975-m6lkrehi 3294 11 ) ) -RRB- cord-335975-m6lkrehi 3294 12 patients patient NNS cord-335975-m6lkrehi 3294 13 . . . cord-335975-m6lkrehi 3295 1 Mortality mortality NN cord-335975-m6lkrehi 3295 2 rate rate NN cord-335975-m6lkrehi 3295 3 at at IN cord-335975-m6lkrehi 3295 4 1 1 CD cord-335975-m6lkrehi 3295 5 year year NN cord-335975-m6lkrehi 3295 6 was be VBD cord-335975-m6lkrehi 3295 7 37.5 37.5 CD cord-335975-m6lkrehi 3295 8 % % NN cord-335975-m6lkrehi 3295 9 . . . cord-335975-m6lkrehi 3296 1 Predictors predictor NNS cord-335975-m6lkrehi 3296 2 of of IN cord-335975-m6lkrehi 3296 3 one one CD cord-335975-m6lkrehi 3296 4 - - HYPH cord-335975-m6lkrehi 3296 5 year year NN cord-335975-m6lkrehi 3296 6 fatal fatal JJ cord-335975-m6lkrehi 3296 7 outcome outcome NN cord-335975-m6lkrehi 3296 8 in in IN cord-335975-m6lkrehi 3296 9 univariate univariate JJ cord-335975-m6lkrehi 3296 10 analysis analysis NN cord-335975-m6lkrehi 3296 11 were be VBD cord-335975-m6lkrehi 3296 12 as as IN cord-335975-m6lkrehi 3296 13 follows follow VBZ cord-335975-m6lkrehi 3296 14 - - : cord-335975-m6lkrehi 3296 15 SAPS SAPS NNP cord-335975-m6lkrehi 3296 16 II ii NN cord-335975-m6lkrehi 3296 17 ( ( -LRB- cord-335975-m6lkrehi 3296 18 p p NN cord-335975-m6lkrehi 3296 19 = = SYM cord-335975-m6lkrehi 3296 20 0.009 0.009 CD cord-335975-m6lkrehi 3296 21 ) ) -RRB- cord-335975-m6lkrehi 3296 22 , , , cord-335975-m6lkrehi 3296 23 Heart heart NN cord-335975-m6lkrehi 3296 24 rate rate NN cord-335975-m6lkrehi 3296 25 at at IN cord-335975-m6lkrehi 3296 26 discharge discharge NN cord-335975-m6lkrehi 3296 27 ( ( -LRB- cord-335975-m6lkrehi 3296 28 p p NN cord-335975-m6lkrehi 3296 29 = = SYM cord-335975-m6lkrehi 3296 30 0.039 0.039 CD cord-335975-m6lkrehi 3296 31 ) ) -RRB- cord-335975-m6lkrehi 3296 32 , , , cord-335975-m6lkrehi 3296 33 decline decline VBP cord-335975-m6lkrehi 3296 34 in in IN cord-335975-m6lkrehi 3296 35 functional functional JJ cord-335975-m6lkrehi 3296 36 status status NN cord-335975-m6lkrehi 3296 37 ( ( -LRB- cord-335975-m6lkrehi 3296 38 p p NN cord-335975-m6lkrehi 3296 39 = = SYM cord-335975-m6lkrehi 3296 40 0.000 0.000 CD cord-335975-m6lkrehi 3296 41 ) ) -RRB- cord-335975-m6lkrehi 3296 42 , , , cord-335975-m6lkrehi 3296 43 World World NNP cord-335975-m6lkrehi 3296 44 health health NN cord-335975-m6lkrehi 3296 45 organization organization NN cord-335975-m6lkrehi 3296 46 ( ( -LRB- cord-335975-m6lkrehi 3296 47 WHO who WP cord-335975-m6lkrehi 3296 48 ) ) -RRB- cord-335975-m6lkrehi 3296 49 performance performance NN cord-335975-m6lkrehi 3296 50 status status NN cord-335975-m6lkrehi 3296 51 at at IN cord-335975-m6lkrehi 3296 52 discharge discharge NN cord-335975-m6lkrehi 3296 53 ( ( -LRB- cord-335975-m6lkrehi 3296 54 p p NN cord-335975-m6lkrehi 3296 55 = = SYM cord-335975-m6lkrehi 3296 56 0.000 0.000 CD cord-335975-m6lkrehi 3296 57 ) ) -RRB- cord-335975-m6lkrehi 3296 58 and and CC cord-335975-m6lkrehi 3296 59 readmission readmission NN cord-335975-m6lkrehi 3296 60 within within IN cord-335975-m6lkrehi 3296 61 1 1 CD cord-335975-m6lkrehi 3296 62 month month NN cord-335975-m6lkrehi 3296 63 ( ( -LRB- cord-335975-m6lkrehi 3296 64 p p NN cord-335975-m6lkrehi 3296 65 = = SYM cord-335975-m6lkrehi 3296 66 0.000 0.000 CD cord-335975-m6lkrehi 3296 67 ) ) -RRB- cord-335975-m6lkrehi 3296 68 . . . cord-335975-m6lkrehi 3297 1 Multivariate multivariate JJ cord-335975-m6lkrehi 3297 2 regression regression NN cord-335975-m6lkrehi 3297 3 showed show VBD cord-335975-m6lkrehi 3297 4 that that IN cord-335975-m6lkrehi 3297 5 SAPS SAPS NNP cord-335975-m6lkrehi 3297 6 II II NNP cord-335975-m6lkrehi 3297 7 ( ( -LRB- cord-335975-m6lkrehi 3297 8 OR or CC cord-335975-m6lkrehi 3297 9 , , , cord-335975-m6lkrehi 3297 10 1.11 1.11 CD cord-335975-m6lkrehi 3297 11 + + SYM cord-335975-m6lkrehi 3297 12 95 95 CD cord-335975-m6lkrehi 3297 13 % % NN cord-335975-m6lkrehi 3297 14 CI CI NNP cord-335975-m6lkrehi 3297 15 [ [ -LRB- cord-335975-m6lkrehi 3297 16 1.02 1.02 CD cord-335975-m6lkrehi 3297 17 - - SYM cord-335975-m6lkrehi 3297 18 1.20 1.20 CD cord-335975-m6lkrehi 3297 19 ] ] -RRB- cord-335975-m6lkrehi 3297 20 + + CC cord-335975-m6lkrehi 3297 21 p p NN cord-335975-m6lkrehi 3297 22 = = SYM cord-335975-m6lkrehi 3297 23 0.01 0.01 CD cord-335975-m6lkrehi 3297 24 ) ) -RRB- cord-335975-m6lkrehi 3297 25 , , , cord-335975-m6lkrehi 3297 26 WHO who WP cord-335975-m6lkrehi 3297 27 Performance performance NN cord-335975-m6lkrehi 3297 28 status status NN cord-335975-m6lkrehi 3297 29 at at IN cord-335975-m6lkrehi 3297 30 discharge discharge NN cord-335975-m6lkrehi 3297 31 ( ( -LRB- cord-335975-m6lkrehi 3297 32 OR or CC cord-335975-m6lkrehi 3297 33 , , , cord-335975-m6lkrehi 3297 34 3.64 3.64 CD cord-335975-m6lkrehi 3297 35 + + SYM cord-335975-m6lkrehi 3297 36 95 95 CD cord-335975-m6lkrehi 3297 37 % % NN cord-335975-m6lkrehi 3297 38 CI ci NN cord-335975-m6lkrehi 3297 39 [ [ -LRB- cord-335975-m6lkrehi 3297 40 1.92 1.92 CD cord-335975-m6lkrehi 3297 41 - - SYM cord-335975-m6lkrehi 3297 42 6.9 6.9 CD cord-335975-m6lkrehi 3297 43 ] ] -RRB- cord-335975-m6lkrehi 3297 44 + + CC cord-335975-m6lkrehi 3297 45 p p NN cord-335975-m6lkrehi 3297 46 = = SYM cord-335975-m6lkrehi 3297 47 0.000 0.000 CD cord-335975-m6lkrehi 3297 48 ) ) -RRB- cord-335975-m6lkrehi 3297 49 and and CC cord-335975-m6lkrehi 3297 50 heart heart NN cord-335975-m6lkrehi 3297 51 rate rate NN cord-335975-m6lkrehi 3297 52 ( ( -LRB- cord-335975-m6lkrehi 3297 53 OR or CC cord-335975-m6lkrehi 3297 54 , , , cord-335975-m6lkrehi 3297 55 1.06 1.06 CD cord-335975-m6lkrehi 3297 56 + + SYM cord-335975-m6lkrehi 3297 57 95 95 CD cord-335975-m6lkrehi 3297 58 % % NN cord-335975-m6lkrehi 3297 59 CI CI NNP cord-335975-m6lkrehi 3297 60 [ [ -LRB- cord-335975-m6lkrehi 3297 61 1.01 1.01 CD cord-335975-m6lkrehi 3297 62 - - SYM cord-335975-m6lkrehi 3297 63 1.12 1.12 CD cord-335975-m6lkrehi 3297 64 ] ] -RRB- cord-335975-m6lkrehi 3297 65 + + CC cord-335975-m6lkrehi 3297 66 p p NN cord-335975-m6lkrehi 3297 67 = = SYM cord-335975-m6lkrehi 3297 68 0.01 0.01 CD cord-335975-m6lkrehi 3297 69 ) ) -RRB- cord-335975-m6lkrehi 3297 70 were be VBD cord-335975-m6lkrehi 3297 71 independent independent JJ cord-335975-m6lkrehi 3297 72 risk risk NN cord-335975-m6lkrehi 3297 73 factors factor NNS cord-335975-m6lkrehi 3297 74 of of IN cord-335975-m6lkrehi 3297 75 one one CD cord-335975-m6lkrehi 3297 76 - - HYPH cord-335975-m6lkrehi 3297 77 year year NN cord-335975-m6lkrehi 3297 78 mortality mortality NN cord-335975-m6lkrehi 3297 79 . . . cord-335975-m6lkrehi 3298 1 Conclusion conclusion NN cord-335975-m6lkrehi 3298 2 : : : cord-335975-m6lkrehi 3299 1 This this DT cord-335975-m6lkrehi 3299 2 study study NN cord-335975-m6lkrehi 3299 3 suggests suggest VBZ cord-335975-m6lkrehi 3299 4 that that IN cord-335975-m6lkrehi 3299 5 age age NN cord-335975-m6lkrehi 3299 6 and and CC cord-335975-m6lkrehi 3299 7 comorbidities comorbiditie NNS cord-335975-m6lkrehi 3299 8 should should MD cord-335975-m6lkrehi 3299 9 not not RB cord-335975-m6lkrehi 3299 10 be be VB cord-335975-m6lkrehi 3299 11 exclusion exclusion NN cord-335975-m6lkrehi 3299 12 criteria criterion NNS cord-335975-m6lkrehi 3299 13 for for IN cord-335975-m6lkrehi 3299 14 ICU ICU NNP cord-335975-m6lkrehi 3299 15 admission admission NN cord-335975-m6lkrehi 3299 16 . . . cord-335975-m6lkrehi 3300 1 In in IN cord-335975-m6lkrehi 3300 2 the the DT cord-335975-m6lkrehi 3300 3 long long JJ cord-335975-m6lkrehi 3300 4 - - HYPH cord-335975-m6lkrehi 3300 5 term term NN cord-335975-m6lkrehi 3300 6 only only RB cord-335975-m6lkrehi 3300 7 SAPS SAPS NNP cord-335975-m6lkrehi 3300 8 II II NNP cord-335975-m6lkrehi 3300 9 , , , cord-335975-m6lkrehi 3300 10 performance performance NN cord-335975-m6lkrehi 3300 11 status status NN cord-335975-m6lkrehi 3300 12 and and CC cord-335975-m6lkrehi 3300 13 heart heart NN cord-335975-m6lkrehi 3300 14 rate rate NN cord-335975-m6lkrehi 3300 15 were be VBD cord-335975-m6lkrehi 3300 16 significantly significantly RB cord-335975-m6lkrehi 3300 17 associated associate VBN cord-335975-m6lkrehi 3300 18 with with IN cord-335975-m6lkrehi 3300 19 one one CD cord-335975-m6lkrehi 3300 20 - - HYPH cord-335975-m6lkrehi 3300 21 year year NN cord-335975-m6lkrehi 3300 22 mortality mortality NN cord-335975-m6lkrehi 3300 23 in in IN cord-335975-m6lkrehi 3300 24 the the DT cord-335975-m6lkrehi 3300 25 elderly elderly JJ cord-335975-m6lkrehi 3300 26 ICU ICU NNP cord-335975-m6lkrehi 3300 27 survivors survivor NNS cord-335975-m6lkrehi 3300 28 . . . cord-335975-m6lkrehi 3301 1 Introduction introduction NN cord-335975-m6lkrehi 3301 2 : : : cord-335975-m6lkrehi 3302 1 Triage Triage NNP cord-335975-m6lkrehi 3302 2 is be VBZ cord-335975-m6lkrehi 3302 3 an an DT cord-335975-m6lkrehi 3302 4 act act NN cord-335975-m6lkrehi 3302 5 performed perform VBN cord-335975-m6lkrehi 3302 6 at at IN cord-335975-m6lkrehi 3302 7 the the DT cord-335975-m6lkrehi 3302 8 entrance entrance NN cord-335975-m6lkrehi 3302 9 of of IN cord-335975-m6lkrehi 3302 10 emergency emergency NN cord-335975-m6lkrehi 3302 11 departments department NNS cord-335975-m6lkrehi 3302 12 ( ( -LRB- cord-335975-m6lkrehi 3302 13 ED ED NNP cord-335975-m6lkrehi 3302 14 's 's POS cord-335975-m6lkrehi 3302 15 ) ) -RRB- cord-335975-m6lkrehi 3302 16 , , , cord-335975-m6lkrehi 3302 17 it -PRON- PRP cord-335975-m6lkrehi 3302 18 allows allow VBZ cord-335975-m6lkrehi 3302 19 the the DT cord-335975-m6lkrehi 3302 20 classification classification NN cord-335975-m6lkrehi 3302 21 of of IN cord-335975-m6lkrehi 3302 22 patients patient NNS cord-335975-m6lkrehi 3302 23 in in IN cord-335975-m6lkrehi 3302 24 different different JJ cord-335975-m6lkrehi 3302 25 categories category NNS cord-335975-m6lkrehi 3302 26 according accord VBG cord-335975-m6lkrehi 3302 27 to to IN cord-335975-m6lkrehi 3302 28 the the DT cord-335975-m6lkrehi 3302 29 seriousness seriousness NN cord-335975-m6lkrehi 3302 30 and and CC cord-335975-m6lkrehi 3302 31 the the DT cord-335975-m6lkrehi 3302 32 priorities priority NNS cord-335975-m6lkrehi 3302 33 of of IN cord-335975-m6lkrehi 3302 34 treatment treatment NN cord-335975-m6lkrehi 3302 35 . . . cord-335975-m6lkrehi 3303 1 Vital vital JJ cord-335975-m6lkrehi 3303 2 emergencies emergency NNS cord-335975-m6lkrehi 3303 3 are be VBP cord-335975-m6lkrehi 3303 4 geared gear VBN cord-335975-m6lkrehi 3303 5 towards towards IN cord-335975-m6lkrehi 3303 6 resuscitation resuscitation NN cord-335975-m6lkrehi 3303 7 room room NN cord-335975-m6lkrehi 3303 8 . . . cord-335975-m6lkrehi 3304 1 In in IN cord-335975-m6lkrehi 3304 2 our -PRON- PRP$ cord-335975-m6lkrehi 3304 3 ED ed NN cord-335975-m6lkrehi 3304 4 , , , cord-335975-m6lkrehi 3304 5 triage triage NN cord-335975-m6lkrehi 3304 6 is be VBZ cord-335975-m6lkrehi 3304 7 not not RB cord-335975-m6lkrehi 3304 8 codified codify VBN cord-335975-m6lkrehi 3304 9 and and CC cord-335975-m6lkrehi 3304 10 is be VBZ cord-335975-m6lkrehi 3304 11 « « `` cord-335975-m6lkrehi 3304 12 done do VBN cord-335975-m6lkrehi 3304 13 » » '' cord-335975-m6lkrehi 3304 14 in in IN cord-335975-m6lkrehi 3304 15 most most JJS cord-335975-m6lkrehi 3304 16 cases case NNS cord-335975-m6lkrehi 3304 17 by by IN cord-335975-m6lkrehi 3304 18 an an DT cord-335975-m6lkrehi 3304 19 unqualified unqualified JJ cord-335975-m6lkrehi 3304 20 staff staff NN cord-335975-m6lkrehi 3304 21 . . . cord-335975-m6lkrehi 3305 1 The the DT cord-335975-m6lkrehi 3305 2 aim aim NN cord-335975-m6lkrehi 3305 3 of of IN cord-335975-m6lkrehi 3305 4 this this DT cord-335975-m6lkrehi 3305 5 work work NN cord-335975-m6lkrehi 3305 6 is be VBZ cord-335975-m6lkrehi 3305 7 to to TO cord-335975-m6lkrehi 3305 8 show show VB cord-335975-m6lkrehi 3305 9 the the DT cord-335975-m6lkrehi 3305 10 impact impact NN cord-335975-m6lkrehi 3305 11 of of IN cord-335975-m6lkrehi 3305 12 absence absence NN cord-335975-m6lkrehi 3305 13 of of IN cord-335975-m6lkrehi 3305 14 triage triage NN cord-335975-m6lkrehi 3305 15 on on IN cord-335975-m6lkrehi 3305 16 the the DT cord-335975-m6lkrehi 3305 17 functionning functionning NN cord-335975-m6lkrehi 3305 18 of of IN cord-335975-m6lkrehi 3305 19 the the DT cord-335975-m6lkrehi 3305 20 resuscitation resuscitation NN cord-335975-m6lkrehi 3305 21 room room NN cord-335975-m6lkrehi 3305 22 . . . cord-335975-m6lkrehi 3306 1 Patients patient NNS cord-335975-m6lkrehi 3306 2 and and CC cord-335975-m6lkrehi 3306 3 methods method NNS cord-335975-m6lkrehi 3307 1 : : : cord-335975-m6lkrehi 3307 2 It -PRON- PRP cord-335975-m6lkrehi 3307 3 's be VBZ cord-335975-m6lkrehi 3307 4 a a DT cord-335975-m6lkrehi 3307 5 prospective prospective JJ cord-335975-m6lkrehi 3307 6 study study NN cord-335975-m6lkrehi 3307 7 , , , cord-335975-m6lkrehi 3307 8 conducted conduct VBN cord-335975-m6lkrehi 3307 9 in in IN cord-335975-m6lkrehi 3307 10 the the DT cord-335975-m6lkrehi 3307 11 ED ED NNP cord-335975-m6lkrehi 3307 12 of of IN cord-335975-m6lkrehi 3307 13 a a DT cord-335975-m6lkrehi 3307 14 university university NN cord-335975-m6lkrehi 3307 15 hospital hospital NN cord-335975-m6lkrehi 3307 16 , , , cord-335975-m6lkrehi 3307 17 over over IN cord-335975-m6lkrehi 3307 18 6 6 CD cord-335975-m6lkrehi 3307 19 months month NNS cord-335975-m6lkrehi 3307 20 , , , cord-335975-m6lkrehi 3307 21 including include VBG cord-335975-m6lkrehi 3307 22 all all DT cord-335975-m6lkrehi 3307 23 patients patient NNS cord-335975-m6lkrehi 3307 24 over over IN cord-335975-m6lkrehi 3307 25 15 15 CD cord-335975-m6lkrehi 3307 26 years year NNS cord-335975-m6lkrehi 3307 27 old old JJ cord-335975-m6lkrehi 3307 28 , , , cord-335975-m6lkrehi 3307 29 admitted admit VBD cord-335975-m6lkrehi 3307 30 at at IN cord-335975-m6lkrehi 3307 31 the the DT cord-335975-m6lkrehi 3307 32 resuscitation resuscitation NN cord-335975-m6lkrehi 3307 33 room room NN cord-335975-m6lkrehi 3307 34 . . . cord-335975-m6lkrehi 3308 1 Epidemiological epidemiological JJ cord-335975-m6lkrehi 3308 2 and and CC cord-335975-m6lkrehi 3308 3 clinical clinical JJ cord-335975-m6lkrehi 3308 4 data datum NNS cord-335975-m6lkrehi 3308 5 of of IN cord-335975-m6lkrehi 3308 6 patients patient NNS cord-335975-m6lkrehi 3308 7 , , , cord-335975-m6lkrehi 3308 8 their -PRON- PRP$ cord-335975-m6lkrehi 3308 9 CCMU CCMU NNP cord-335975-m6lkrehi 3308 10 classification classification NN cord-335975-m6lkrehi 3308 11 ( ( -LRB- cord-335975-m6lkrehi 3308 12 Classification Classification NNP cord-335975-m6lkrehi 3308 13 Clinique Clinique NNP cord-335975-m6lkrehi 3308 14 des des FW cord-335975-m6lkrehi 3308 15 Malades Malades NNP cord-335975-m6lkrehi 3308 16 aux aux NNP cord-335975-m6lkrehi 3308 17 Urgences Urgences NNP cord-335975-m6lkrehi 3308 18 ) ) -RRB- cord-335975-m6lkrehi 3308 19 have have VBP cord-335975-m6lkrehi 3308 20 been be VBN cord-335975-m6lkrehi 3308 21 specified specify VBN cord-335975-m6lkrehi 3308 22 , , , cord-335975-m6lkrehi 3308 23 as as RB cord-335975-m6lkrehi 3308 24 well well RB cord-335975-m6lkrehi 3308 25 as as IN cord-335975-m6lkrehi 3308 26 their -PRON- PRP$ cord-335975-m6lkrehi 3308 27 outcomes outcome NNS cord-335975-m6lkrehi 3308 28 . . . cord-335975-m6lkrehi 3309 1 We -PRON- PRP cord-335975-m6lkrehi 3309 2 collected collect VBD cord-335975-m6lkrehi 3309 3 366 366 CD cord-335975-m6lkrehi 3309 4 patients patient NNS cord-335975-m6lkrehi 3309 5 . . . cord-335975-m6lkrehi 3310 1 The the DT cord-335975-m6lkrehi 3310 2 average average JJ cord-335975-m6lkrehi 3310 3 age age NN cord-335975-m6lkrehi 3310 4 was be VBD cord-335975-m6lkrehi 3310 5 51.24 51.24 CD cord-335975-m6lkrehi 3310 6 years year NNS cord-335975-m6lkrehi 3310 7 old old JJ cord-335975-m6lkrehi 3310 8 ( ( -LRB- cord-335975-m6lkrehi 3310 9 15 15 CD cord-335975-m6lkrehi 3310 10 - - SYM cord-335975-m6lkrehi 3310 11 97 97 CD cord-335975-m6lkrehi 3310 12 years year NNS cord-335975-m6lkrehi 3310 13 ) ) -RRB- cord-335975-m6lkrehi 3310 14 , , , cord-335975-m6lkrehi 3310 15 for for IN cord-335975-m6lkrehi 3310 16 a a DT cord-335975-m6lkrehi 3310 17 sex sex NN cord-335975-m6lkrehi 3310 18 ratio ratio NN cord-335975-m6lkrehi 3310 19 of of IN cord-335975-m6lkrehi 3310 20 1.57 1.57 CD cord-335975-m6lkrehi 3310 21 . . . cord-335975-m6lkrehi 3311 1 Forty forty CD cord-335975-m6lkrehi 3311 2 patients patient NNS cord-335975-m6lkrehi 3311 3 ( ( -LRB- cord-335975-m6lkrehi 3311 4 10.1 10.1 CD cord-335975-m6lkrehi 3311 5 % % NN cord-335975-m6lkrehi 3311 6 ) ) -RRB- cord-335975-m6lkrehi 3311 7 arrived arrive VBD cord-335975-m6lkrehi 3311 8 « « `` cord-335975-m6lkrehi 3311 9 standing stand VBG cord-335975-m6lkrehi 3311 10 » » NNP cord-335975-m6lkrehi 3311 11 at at IN cord-335975-m6lkrehi 3311 12 the the DT cord-335975-m6lkrehi 3311 13 ED ED NNP cord-335975-m6lkrehi 3311 14 . . . cord-335975-m6lkrehi 3312 1 Patients patient NNS cord-335975-m6lkrehi 3312 2 CCMU CCMU NNP cord-335975-m6lkrehi 3312 3 1 1 CD cord-335975-m6lkrehi 3312 4 and and CC cord-335975-m6lkrehi 3312 5 2 2 CD cord-335975-m6lkrehi 3312 6 represented represent VBD cord-335975-m6lkrehi 3312 7 41.3 41.3 CD cord-335975-m6lkrehi 3312 8 % % NN cord-335975-m6lkrehi 3312 9 of of IN cord-335975-m6lkrehi 3312 10 these these DT cord-335975-m6lkrehi 3312 11 admissions admission NNS cord-335975-m6lkrehi 3312 12 . . . cord-335975-m6lkrehi 3313 1 The the DT cord-335975-m6lkrehi 3313 2 systolic systolic JJ cord-335975-m6lkrehi 3313 3 blood blood NN cord-335975-m6lkrehi 3313 4 pressure pressure NN cord-335975-m6lkrehi 3313 5 was be VBD cord-335975-m6lkrehi 3313 6 under under IN cord-335975-m6lkrehi 3313 7 90 90 CD cord-335975-m6lkrehi 3313 8 mmHg mmHg NNS cord-335975-m6lkrehi 3313 9 in in IN cord-335975-m6lkrehi 3313 10 25 25 CD cord-335975-m6lkrehi 3313 11 % % NN cord-335975-m6lkrehi 3313 12 of of IN cord-335975-m6lkrehi 3313 13 cases case NNS cord-335975-m6lkrehi 3313 14 , , , cord-335975-m6lkrehi 3313 15 the the DT cord-335975-m6lkrehi 3313 16 Glasgow Glasgow NNP cord-335975-m6lkrehi 3313 17 coma coma NN cord-335975-m6lkrehi 3313 18 scale scale NN cord-335975-m6lkrehi 3313 19 < < XX cord-335975-m6lkrehi 3313 20 8.15 8.15 CD cord-335975-m6lkrehi 3313 21 in in IN cord-335975-m6lkrehi 3313 22 18 18 CD cord-335975-m6lkrehi 3313 23 % % NN cord-335975-m6lkrehi 3313 24 of of IN cord-335975-m6lkrehi 3313 25 cases case NNS cord-335975-m6lkrehi 3313 26 , , , cord-335975-m6lkrehi 3313 27 and and CC cord-335975-m6lkrehi 3313 28 the the DT cord-335975-m6lkrehi 3313 29 SpO2 SpO2 NNP cord-335975-m6lkrehi 3313 30 < < XX cord-335975-m6lkrehi 3313 31 90 90 CD cord-335975-m6lkrehi 3313 32 % % NN cord-335975-m6lkrehi 3313 33 in in IN cord-335975-m6lkrehi 3313 34 23 23 CD cord-335975-m6lkrehi 3313 35 % % NN cord-335975-m6lkrehi 3313 36 of of IN cord-335975-m6lkrehi 3313 37 cases case NNS cord-335975-m6lkrehi 3313 38 . . . cord-335975-m6lkrehi 3314 1 Mortality mortality NN cord-335975-m6lkrehi 3314 2 was be VBD cord-335975-m6lkrehi 3314 3 5.5 5.5 CD cord-335975-m6lkrehi 3314 4 % % NN cord-335975-m6lkrehi 3314 5 . . . cord-335975-m6lkrehi 3315 1 The the DT cord-335975-m6lkrehi 3315 2 other other JJ cord-335975-m6lkrehi 3315 3 patients patient NNS cord-335975-m6lkrehi 3315 4 were be VBD cord-335975-m6lkrehi 3315 5 admitted admit VBN cord-335975-m6lkrehi 3315 6 at at IN cord-335975-m6lkrehi 3315 7 the the DT cord-335975-m6lkrehi 3315 8 intensive intensive JJ cord-335975-m6lkrehi 3315 9 care care NN cord-335975-m6lkrehi 3315 10 unit unit NN cord-335975-m6lkrehi 3315 11 ( ( -LRB- cord-335975-m6lkrehi 3315 12 36 36 CD cord-335975-m6lkrehi 3315 13 % % NN cord-335975-m6lkrehi 3315 14 ) ) -RRB- cord-335975-m6lkrehi 3315 15 , , , cord-335975-m6lkrehi 3315 16 at at IN cord-335975-m6lkrehi 3315 17 the the DT cord-335975-m6lkrehi 3315 18 short short JJ cord-335975-m6lkrehi 3315 19 stay stay NN cord-335975-m6lkrehi 3315 20 hospitalization hospitalization NN cord-335975-m6lkrehi 3315 21 unit unit NN cord-335975-m6lkrehi 3315 22 ( ( -LRB- cord-335975-m6lkrehi 3315 23 33.6 33.6 CD cord-335975-m6lkrehi 3315 24 % % NN cord-335975-m6lkrehi 3315 25 ) ) -RRB- cord-335975-m6lkrehi 3315 26 , , , cord-335975-m6lkrehi 3315 27 at at IN cord-335975-m6lkrehi 3315 28 the the DT cord-335975-m6lkrehi 3315 29 operating operating NN cord-335975-m6lkrehi 3315 30 room room NN cord-335975-m6lkrehi 3315 31 ( ( -LRB- cord-335975-m6lkrehi 3315 32 13.4 13.4 CD cord-335975-m6lkrehi 3315 33 % % NN cord-335975-m6lkrehi 3315 34 ) ) -RRB- cord-335975-m6lkrehi 3315 35 , , , cord-335975-m6lkrehi 3315 36 or or CC cord-335975-m6lkrehi 3315 37 transferred transfer VBN cord-335975-m6lkrehi 3315 38 to to IN cord-335975-m6lkrehi 3315 39 other other JJ cord-335975-m6lkrehi 3315 40 departments department NNS cord-335975-m6lkrehi 3315 41 ( ( -LRB- cord-335975-m6lkrehi 3315 42 9.2 9.2 CD cord-335975-m6lkrehi 3315 43 % % NN cord-335975-m6lkrehi 3315 44 ) ) -RRB- cord-335975-m6lkrehi 3315 45 . . . cord-335975-m6lkrehi 3316 1 Discussion discussion NN cord-335975-m6lkrehi 3316 2 : : : cord-335975-m6lkrehi 3317 1 The the DT cord-335975-m6lkrehi 3317 2 patients patient NNS cord-335975-m6lkrehi 3317 3 CCMU CCMU NNP cord-335975-m6lkrehi 3317 4 1 1 CD cord-335975-m6lkrehi 3317 5 and and CC cord-335975-m6lkrehi 3317 6 2 2 CD cord-335975-m6lkrehi 3317 7 arrived arrive VBD cord-335975-m6lkrehi 3317 8 by by IN cord-335975-m6lkrehi 3317 9 ambulance ambulance NN cord-335975-m6lkrehi 3317 10 , , , cord-335975-m6lkrehi 3318 1 « « `` cord-335975-m6lkrehi 3318 2 lying lie VBG cord-335975-m6lkrehi 3318 3 » » NNP cord-335975-m6lkrehi 3318 4 , , , cord-335975-m6lkrehi 3318 5 were be VBD cord-335975-m6lkrehi 3318 6 considered consider VBN cord-335975-m6lkrehi 3318 7 as as RB cord-335975-m6lkrehi 3318 8 severe severe JJ cord-335975-m6lkrehi 3318 9 . . . cord-335975-m6lkrehi 3319 1 The the DT cord-335975-m6lkrehi 3319 2 proximity proximity NN cord-335975-m6lkrehi 3319 3 of of IN cord-335975-m6lkrehi 3319 4 the the DT cord-335975-m6lkrehi 3319 5 resuscitation resuscitation NN cord-335975-m6lkrehi 3319 6 room room NN cord-335975-m6lkrehi 3319 7 of of IN cord-335975-m6lkrehi 3319 8 consultation consultation NN cord-335975-m6lkrehi 3319 9 rooms room NNS cord-335975-m6lkrehi 3319 10 allows allow VBZ cord-335975-m6lkrehi 3319 11 it -PRON- PRP cord-335975-m6lkrehi 3319 12 to to TO cord-335975-m6lkrehi 3319 13 be be VB cord-335975-m6lkrehi 3319 14 used use VBN cord-335975-m6lkrehi 3319 15 sometimes sometimes RB cord-335975-m6lkrehi 3319 16 in in IN cord-335975-m6lkrehi 3319 17 flows flow NNS cord-335975-m6lkrehi 3319 18 ' ' POS cord-335975-m6lkrehi 3319 19 management management NN cord-335975-m6lkrehi 3319 20 and and CC cord-335975-m6lkrehi 3319 21 as as IN cord-335975-m6lkrehi 3319 22 a a DT cord-335975-m6lkrehi 3319 23 place place NN cord-335975-m6lkrehi 3319 24 of of IN cord-335975-m6lkrehi 3319 25 triage triage NN cord-335975-m6lkrehi 3319 26 . . . cord-335975-m6lkrehi 3320 1 The the DT cord-335975-m6lkrehi 3320 2 patients patient NNS cord-335975-m6lkrehi 3320 3 transferred transfer VBD cord-335975-m6lkrehi 3320 4 straight straight RB cord-335975-m6lkrehi 3320 5 to to IN cord-335975-m6lkrehi 3320 6 services service NNS cord-335975-m6lkrehi 3320 7 did do VBD cord-335975-m6lkrehi 3320 8 n't not RB cord-335975-m6lkrehi 3320 9 show show VB cord-335975-m6lkrehi 3320 10 signs sign NNS cord-335975-m6lkrehi 3320 11 of of IN cord-335975-m6lkrehi 3320 12 vital vital JJ cord-335975-m6lkrehi 3320 13 distress distress NN cord-335975-m6lkrehi 3320 14 motiving motive VBG cord-335975-m6lkrehi 3320 15 their -PRON- PRP$ cord-335975-m6lkrehi 3320 16 initial initial JJ cord-335975-m6lkrehi 3320 17 admission admission NN cord-335975-m6lkrehi 3320 18 at at IN cord-335975-m6lkrehi 3320 19 resuscitation resuscitation NN cord-335975-m6lkrehi 3320 20 room room NN cord-335975-m6lkrehi 3320 21 or or CC cord-335975-m6lkrehi 3320 22 even even RB cord-335975-m6lkrehi 3320 23 at at IN cord-335975-m6lkrehi 3320 24 ED ED NNP cord-335975-m6lkrehi 3320 25 . . . cord-335975-m6lkrehi 3321 1 Those those DT cord-335975-m6lkrehi 3321 2 admitted admit VBN cord-335975-m6lkrehi 3321 3 at at IN cord-335975-m6lkrehi 3321 4 the the DT cord-335975-m6lkrehi 3321 5 short short JJ cord-335975-m6lkrehi 3321 6 stay stay NN cord-335975-m6lkrehi 3321 7 hospitalization hospitalization NN cord-335975-m6lkrehi 3321 8 unit unit NN cord-335975-m6lkrehi 3321 9 were be VBD cord-335975-m6lkrehi 3321 10 steady steady JJ cord-335975-m6lkrehi 3321 11 , , , cord-335975-m6lkrehi 3321 12 but but CC cord-335975-m6lkrehi 3321 13 needed need VBD cord-335975-m6lkrehi 3321 14 complementary complementary JJ cord-335975-m6lkrehi 3321 15 examinations examination NNS cord-335975-m6lkrehi 3321 16 , , , cord-335975-m6lkrehi 3321 17 specialized specialized JJ cord-335975-m6lkrehi 3321 18 expert expert NN cord-335975-m6lkrehi 3321 19 advice advice NN cord-335975-m6lkrehi 3321 20 , , , cord-335975-m6lkrehi 3321 21 or or CC cord-335975-m6lkrehi 3321 22 were be VBD cord-335975-m6lkrehi 3321 23 waiting wait VBG cord-335975-m6lkrehi 3321 24 for for IN cord-335975-m6lkrehi 3321 25 a a DT cord-335975-m6lkrehi 3321 26 downstream downstream JJ cord-335975-m6lkrehi 3321 27 bed bed NN cord-335975-m6lkrehi 3321 28 . . . cord-335975-m6lkrehi 3322 1 Conclusion conclusion NN cord-335975-m6lkrehi 3322 2 : : : cord-335975-m6lkrehi 3323 1 A a DT cord-335975-m6lkrehi 3323 2 triage triage NN cord-335975-m6lkrehi 3323 3 system system NN cord-335975-m6lkrehi 3323 4 must must MD cord-335975-m6lkrehi 3323 5 be be VB cord-335975-m6lkrehi 3323 6 introduced introduce VBN cord-335975-m6lkrehi 3323 7 at at IN cord-335975-m6lkrehi 3323 8 the the DT cord-335975-m6lkrehi 3323 9 entrance entrance NN cord-335975-m6lkrehi 3323 10 of of IN cord-335975-m6lkrehi 3323 11 our -PRON- PRP$ cord-335975-m6lkrehi 3323 12 emergency emergency NN cord-335975-m6lkrehi 3323 13 departments department NNS cord-335975-m6lkrehi 3323 14 . . . cord-335975-m6lkrehi 3324 1 The the DT cord-335975-m6lkrehi 3324 2 staff staff NN cord-335975-m6lkrehi 3324 3 involved involve VBN cord-335975-m6lkrehi 3324 4 in in IN cord-335975-m6lkrehi 3324 5 that that DT cord-335975-m6lkrehi 3324 6 sorting sorting NN cord-335975-m6lkrehi 3324 7 must must MD cord-335975-m6lkrehi 3324 8 be be VB cord-335975-m6lkrehi 3324 9 identified identify VBN cord-335975-m6lkrehi 3324 10 , , , cord-335975-m6lkrehi 3324 11 and and CC cord-335975-m6lkrehi 3324 12 disposing dispose VBG cord-335975-m6lkrehi 3324 13 of of IN cord-335975-m6lkrehi 3324 14 a a DT cord-335975-m6lkrehi 3324 15 triage triage NN cord-335975-m6lkrehi 3324 16 scale scale NN cord-335975-m6lkrehi 3324 17 in in IN cord-335975-m6lkrehi 3324 18 order order NN cord-335975-m6lkrehi 3324 19 to to TO cord-335975-m6lkrehi 3324 20 figure figure VB cord-335975-m6lkrehi 3324 21 out out RP cord-335975-m6lkrehi 3324 22 the the DT cord-335975-m6lkrehi 3324 23 degree degree NN cord-335975-m6lkrehi 3324 24 of of IN cord-335975-m6lkrehi 3324 25 priority priority NN cord-335975-m6lkrehi 3324 26 associated associate VBN cord-335975-m6lkrehi 3324 27 to to IN cord-335975-m6lkrehi 3324 28 patients patient NNS cord-335975-m6lkrehi 3324 29 conditions condition NNS cord-335975-m6lkrehi 3324 30 , , , cord-335975-m6lkrehi 3324 31 and and CC cord-335975-m6lkrehi 3324 32 direct direct VB cord-335975-m6lkrehi 3324 33 the the DT cord-335975-m6lkrehi 3324 34 ones one NNS cord-335975-m6lkrehi 3324 35 needing need VBG cord-335975-m6lkrehi 3324 36 urgent urgent JJ cord-335975-m6lkrehi 3324 37 care care NN cord-335975-m6lkrehi 3324 38 towards towards IN cord-335975-m6lkrehi 3324 39 the the DT cord-335975-m6lkrehi 3324 40 resuscitation resuscitation NN cord-335975-m6lkrehi 3324 41 room room NN cord-335975-m6lkrehi 3324 42 . . . cord-335975-m6lkrehi 3325 1 Results result NNS cord-335975-m6lkrehi 3325 2 : : : cord-335975-m6lkrehi 3326 1 One one CD cord-335975-m6lkrehi 3326 2 hundred hundred CD cord-335975-m6lkrehi 3326 3 patients patient NNS cord-335975-m6lkrehi 3326 4 were be VBD cord-335975-m6lkrehi 3326 5 included include VBN cord-335975-m6lkrehi 3326 6 , , , cord-335975-m6lkrehi 3326 7 with with IN cord-335975-m6lkrehi 3326 8 average average JJ cord-335975-m6lkrehi 3326 9 age age NN cord-335975-m6lkrehi 3326 10 of of IN cord-335975-m6lkrehi 3326 11 59.5 59.5 CD cord-335975-m6lkrehi 3326 12 years year NNS cord-335975-m6lkrehi 3326 13 old old JJ cord-335975-m6lkrehi 3326 14 ( ( -LRB- cord-335975-m6lkrehi 3326 15 25 25 CD cord-335975-m6lkrehi 3326 16 - - SYM cord-335975-m6lkrehi 3326 17 84 84 CD cord-335975-m6lkrehi 3326 18 ) ) -RRB- cord-335975-m6lkrehi 3326 19 and and CC cord-335975-m6lkrehi 3326 20 sex sex NN cord-335975-m6lkrehi 3326 21 ratio ratio NN cord-335975-m6lkrehi 3326 22 of of IN cord-335975-m6lkrehi 3326 23 1.12 1.12 CD cord-335975-m6lkrehi 3326 24 . . . cord-335975-m6lkrehi 3327 1 These these DT cord-335975-m6lkrehi 3327 2 patients patient NNS cord-335975-m6lkrehi 3327 3 were be VBD cord-335975-m6lkrehi 3327 4 brought bring VBN cord-335975-m6lkrehi 3327 5 to to IN cord-335975-m6lkrehi 3327 6 emergencies emergency NNS cord-335975-m6lkrehi 3327 7 by by IN cord-335975-m6lkrehi 3327 8 their -PRON- PRP$ cord-335975-m6lkrehi 3327 9 family family NN cord-335975-m6lkrehi 3327 10 in in IN cord-335975-m6lkrehi 3327 11 83 83 CD cord-335975-m6lkrehi 3327 12 % % NN cord-335975-m6lkrehi 3327 13 of of IN cord-335975-m6lkrehi 3327 14 cases case NNS cord-335975-m6lkrehi 3327 15 . . . cord-335975-m6lkrehi 3328 1 Reasons reason NNS cord-335975-m6lkrehi 3328 2 for for IN cord-335975-m6lkrehi 3328 3 admissions admission NNS cord-335975-m6lkrehi 3328 4 were be VBD cord-335975-m6lkrehi 3328 5 varied varied JJ cord-335975-m6lkrehi 3328 6 , , , cord-335975-m6lkrehi 3328 7 severe severe JJ cord-335975-m6lkrehi 3328 8 deterioration deterioration NN cord-335975-m6lkrehi 3328 9 of of IN cord-335975-m6lkrehi 3328 10 their -PRON- PRP$ cord-335975-m6lkrehi 3328 11 general general JJ cord-335975-m6lkrehi 3328 12 condition condition NN cord-335975-m6lkrehi 3328 13 ( ( -LRB- cord-335975-m6lkrehi 3328 14 41 41 CD cord-335975-m6lkrehi 3328 15 % % NN cord-335975-m6lkrehi 3328 16 ) ) -RRB- cord-335975-m6lkrehi 3328 17 , , , cord-335975-m6lkrehi 3328 18 alteration alteration NN cord-335975-m6lkrehi 3328 19 of of IN cord-335975-m6lkrehi 3328 20 consciousness consciousness NN cord-335975-m6lkrehi 3328 21 ( ( -LRB- cord-335975-m6lkrehi 3328 22 28 28 CD cord-335975-m6lkrehi 3328 23 % % NN cord-335975-m6lkrehi 3328 24 ) ) -RRB- cord-335975-m6lkrehi 3328 25 , , , cord-335975-m6lkrehi 3328 26 respiratory respiratory JJ cord-335975-m6lkrehi 3328 27 distress distress NN cord-335975-m6lkrehi 3328 28 ( ( -LRB- cord-335975-m6lkrehi 3328 29 13 13 CD cord-335975-m6lkrehi 3328 30 % % NN cord-335975-m6lkrehi 3328 31 ) ) -RRB- cord-335975-m6lkrehi 3328 32 , , , cord-335975-m6lkrehi 3328 33 convulsive convulsive JJ cord-335975-m6lkrehi 3328 34 seizures seizure NNS cord-335975-m6lkrehi 3328 35 ( ( -LRB- cord-335975-m6lkrehi 3328 36 12 12 CD cord-335975-m6lkrehi 3328 37 % % NN cord-335975-m6lkrehi 3328 38 ) ) -RRB- cord-335975-m6lkrehi 3328 39 . . . cord-335975-m6lkrehi 3329 1 Therapeutic therapeutic JJ cord-335975-m6lkrehi 3329 2 interventions intervention NNS cord-335975-m6lkrehi 3329 3 were be VBD cord-335975-m6lkrehi 3329 4 cardio cardio JJ cord-335975-m6lkrehi 3329 5 - - HYPH cord-335975-m6lkrehi 3329 6 pulmonary pulmonary JJ cord-335975-m6lkrehi 3329 7 resuscitation resuscitation NN cord-335975-m6lkrehi 3329 8 ( ( -LRB- cord-335975-m6lkrehi 3329 9 2 2 CD cord-335975-m6lkrehi 3329 10 % % NN cord-335975-m6lkrehi 3329 11 ) ) -RRB- cord-335975-m6lkrehi 3329 12 , , , cord-335975-m6lkrehi 3329 13 fluid fluid JJ cord-335975-m6lkrehi 3329 14 volume volume NN cord-335975-m6lkrehi 3329 15 expansion expansion NN cord-335975-m6lkrehi 3329 16 ( ( -LRB- cord-335975-m6lkrehi 3329 17 91 91 CD cord-335975-m6lkrehi 3329 18 % % NN cord-335975-m6lkrehi 3329 19 ) ) -RRB- cord-335975-m6lkrehi 3329 20 , , , cord-335975-m6lkrehi 3329 21 mechanical mechanical JJ cord-335975-m6lkrehi 3329 22 ventilation ventilation NN cord-335975-m6lkrehi 3329 23 ( ( -LRB- cord-335975-m6lkrehi 3329 24 15 15 CD cord-335975-m6lkrehi 3329 25 % % NN cord-335975-m6lkrehi 3329 26 ) ) -RRB- cord-335975-m6lkrehi 3329 27 , , , cord-335975-m6lkrehi 3329 28 administration administration NN cord-335975-m6lkrehi 3329 29 of of IN cord-335975-m6lkrehi 3329 30 vasopressors vasopressor NNS cord-335975-m6lkrehi 3329 31 ( ( -LRB- cord-335975-m6lkrehi 3329 32 23 23 CD cord-335975-m6lkrehi 3329 33 % % NN cord-335975-m6lkrehi 3329 34 ) ) -RRB- cord-335975-m6lkrehi 3329 35 and and CC cord-335975-m6lkrehi 3329 36 anticonvulsants anticonvulsant NNS cord-335975-m6lkrehi 3329 37 ( ( -LRB- cord-335975-m6lkrehi 3329 38 12 12 CD cord-335975-m6lkrehi 3329 39 % % NN cord-335975-m6lkrehi 3329 40 ) ) -RRB- cord-335975-m6lkrehi 3329 41 . . . cord-335975-m6lkrehi 3330 1 Mortality mortality NN cord-335975-m6lkrehi 3330 2 at at IN cord-335975-m6lkrehi 3330 3 the the DT cord-335975-m6lkrehi 3330 4 resuscitation resuscitation NN cord-335975-m6lkrehi 3330 5 room room NN cord-335975-m6lkrehi 3330 6 was be VBD cord-335975-m6lkrehi 3330 7 13 13 CD cord-335975-m6lkrehi 3330 8 % % NN cord-335975-m6lkrehi 3330 9 . . . cord-335975-m6lkrehi 3331 1 Thirty thirty CD cord-335975-m6lkrehi 3331 2 eight eight CD cord-335975-m6lkrehi 3331 3 patients patient NNS cord-335975-m6lkrehi 3331 4 were be VBD cord-335975-m6lkrehi 3331 5 admitted admit VBN cord-335975-m6lkrehi 3331 6 at at IN cord-335975-m6lkrehi 3331 7 the the DT cord-335975-m6lkrehi 3331 8 intensive intensive JJ cord-335975-m6lkrehi 3331 9 care care NN cord-335975-m6lkrehi 3331 10 unit unit NN cord-335975-m6lkrehi 3331 11 , , , cord-335975-m6lkrehi 3331 12 equally equally RB cord-335975-m6lkrehi 3331 13 at at IN cord-335975-m6lkrehi 3331 14 the the DT cord-335975-m6lkrehi 3331 15 short short JJ cord-335975-m6lkrehi 3331 16 stay stay NN cord-335975-m6lkrehi 3331 17 hospitalization hospitalization NN cord-335975-m6lkrehi 3331 18 unit unit NN cord-335975-m6lkrehi 3331 19 ( ( -LRB- cord-335975-m6lkrehi 3331 20 SSU SSU NNP cord-335975-m6lkrehi 3331 21 ) ) -RRB- cord-335975-m6lkrehi 3331 22 of of IN cord-335975-m6lkrehi 3331 23 ED ED NNP cord-335975-m6lkrehi 3331 24 . . . cord-335975-m6lkrehi 3332 1 Two two CD cord-335975-m6lkrehi 3332 2 patients patient NNS cord-335975-m6lkrehi 3332 3 returned return VBD cord-335975-m6lkrehi 3332 4 home home RB cord-335975-m6lkrehi 3332 5 at at IN cord-335975-m6lkrehi 3332 6 the the DT cord-335975-m6lkrehi 3332 7 request request NN cord-335975-m6lkrehi 3332 8 of of IN cord-335975-m6lkrehi 3332 9 their -PRON- PRP$ cord-335975-m6lkrehi 3332 10 family family NN cord-335975-m6lkrehi 3332 11 . . . cord-335975-m6lkrehi 3333 1 Discussion discussion NN cord-335975-m6lkrehi 3333 2 : : : cord-335975-m6lkrehi 3334 1 These these DT cord-335975-m6lkrehi 3334 2 results result NNS cord-335975-m6lkrehi 3334 3 show show VBP cord-335975-m6lkrehi 3334 4 that that IN cord-335975-m6lkrehi 3334 5 ED ED NNP cord-335975-m6lkrehi 3334 6 's 's POS cord-335975-m6lkrehi 3334 7 remain remain VBP cord-335975-m6lkrehi 3334 8 the the DT cord-335975-m6lkrehi 3334 9 last last JJ cord-335975-m6lkrehi 3334 10 resort resort NN cord-335975-m6lkrehi 3334 11 in in IN cord-335975-m6lkrehi 3334 12 front front NN cord-335975-m6lkrehi 3334 13 of of IN cord-335975-m6lkrehi 3334 14 oncology oncology NN cord-335975-m6lkrehi 3334 15 patient patient NN cord-335975-m6lkrehi 3334 16 who who WP cord-335975-m6lkrehi 3334 17 is be VBZ cord-335975-m6lkrehi 3334 18 deteriorating deteriorate VBG cord-335975-m6lkrehi 3334 19 , , , cord-335975-m6lkrehi 3334 20 the the DT cord-335975-m6lkrehi 3334 21 occurrence occurrence NN cord-335975-m6lkrehi 3334 22 of of IN cord-335975-m6lkrehi 3334 23 complications complication NNS cord-335975-m6lkrehi 3334 24 , , , cord-335975-m6lkrehi 3334 25 and and CC cord-335975-m6lkrehi 3334 26 sometimes sometimes RB cord-335975-m6lkrehi 3334 27 , , , cord-335975-m6lkrehi 3334 28 the the DT cord-335975-m6lkrehi 3334 29 psychological psychological JJ cord-335975-m6lkrehi 3334 30 exhaustion exhaustion NN cord-335975-m6lkrehi 3334 31 or or CC cord-335975-m6lkrehi 3334 32 family family NN cord-335975-m6lkrehi 3334 33 's 's POS cord-335975-m6lkrehi 3334 34 obstinacy obstinacy NN cord-335975-m6lkrehi 3334 35 . . . cord-335975-m6lkrehi 3335 1 Emergencies emergency NNS cord-335975-m6lkrehi 3335 2 departments department NNS cord-335975-m6lkrehi 3335 3 continue continue VBP cord-335975-m6lkrehi 3335 4 admitting admit VBG cord-335975-m6lkrehi 3335 5 patients patient NNS cord-335975-m6lkrehi 3335 6 with with IN cord-335975-m6lkrehi 3335 7 terminal terminal JJ cord-335975-m6lkrehi 3335 8 cancer cancer NN cord-335975-m6lkrehi 3335 9 , , , cord-335975-m6lkrehi 3335 10 but but CC cord-335975-m6lkrehi 3335 11 are be VBP cord-335975-m6lkrehi 3335 12 not not RB cord-335975-m6lkrehi 3335 13 organized organize VBN cord-335975-m6lkrehi 3335 14 for for IN cord-335975-m6lkrehi 3335 15 medium medium JJ cord-335975-m6lkrehi 3335 16 and and CC cord-335975-m6lkrehi 3335 17 long long JJ cord-335975-m6lkrehi 3335 18 term term NN cord-335975-m6lkrehi 3335 19 care care NN cord-335975-m6lkrehi 3335 20 . . . cord-335975-m6lkrehi 3336 1 The the DT cord-335975-m6lkrehi 3336 2 creation creation NN cord-335975-m6lkrehi 3336 3 of of IN cord-335975-m6lkrehi 3336 4 a a DT cord-335975-m6lkrehi 3336 5 palliative palliative JJ cord-335975-m6lkrehi 3336 6 care care NN cord-335975-m6lkrehi 3336 7 unit unit NN cord-335975-m6lkrehi 3336 8 and and CC cord-335975-m6lkrehi 3336 9 the the DT cord-335975-m6lkrehi 3336 10 organization organization NN cord-335975-m6lkrehi 3336 11 of of IN cord-335975-m6lkrehi 3336 12 home home NN cord-335975-m6lkrehi 3336 13 - - HYPH cord-335975-m6lkrehi 3336 14 based base VBN cord-335975-m6lkrehi 3336 15 care care NN cord-335975-m6lkrehi 3336 16 will will MD cord-335975-m6lkrehi 3336 17 allow allow VB cord-335975-m6lkrehi 3336 18 the the DT cord-335975-m6lkrehi 3336 19 prevention prevention NN cord-335975-m6lkrehi 3336 20 and and CC cord-335975-m6lkrehi 3336 21 treatment treatment NN cord-335975-m6lkrehi 3336 22 of of IN cord-335975-m6lkrehi 3336 23 complications complication NNS cord-335975-m6lkrehi 3336 24 as as RB cord-335975-m6lkrehi 3336 25 well well RB cord-335975-m6lkrehi 3336 26 as as IN cord-335975-m6lkrehi 3336 27 a a DT cord-335975-m6lkrehi 3336 28 psychological psychological JJ cord-335975-m6lkrehi 3336 29 care care NN cord-335975-m6lkrehi 3336 30 , , , cord-335975-m6lkrehi 3336 31 thus thus RB cord-335975-m6lkrehi 3336 32 improving improve VBG cord-335975-m6lkrehi 3336 33 the the DT cord-335975-m6lkrehi 3336 34 living live VBG cord-335975-m6lkrehi 3336 35 quality quality NN cord-335975-m6lkrehi 3336 36 of of IN cord-335975-m6lkrehi 3336 37 these these DT cord-335975-m6lkrehi 3336 38 patients patient NNS cord-335975-m6lkrehi 3336 39 and and CC cord-335975-m6lkrehi 3336 40 their -PRON- PRP$ cord-335975-m6lkrehi 3336 41 relatives relative NNS cord-335975-m6lkrehi 3336 42 . . . cord-335975-m6lkrehi 3337 1 Refusal refusal NN cord-335975-m6lkrehi 3337 2 of of IN cord-335975-m6lkrehi 3337 3 intensive intensive JJ cord-335975-m6lkrehi 3337 4 care care NN cord-335975-m6lkrehi 3337 5 admission admission NN cord-335975-m6lkrehi 3337 6 : : : cord-335975-m6lkrehi 3337 7 assessment assessment NN cord-335975-m6lkrehi 3337 8 of of IN cord-335975-m6lkrehi 3337 9 a a DT cord-335975-m6lkrehi 3337 10 Tunisian tunisian JJ cord-335975-m6lkrehi 3337 11 ICU ICU NNP cord-335975-m6lkrehi 3337 12 practices practice NNS cord-335975-m6lkrehi 3337 13 Merhabene Merhabene NNP cord-335975-m6lkrehi 3337 14 Takoua Takoua NNP cord-335975-m6lkrehi 3337 15 Introduction introduction NN cord-335975-m6lkrehi 3337 16 : : : cord-335975-m6lkrehi 3337 17 Need need NN cord-335975-m6lkrehi 3337 18 of of IN cord-335975-m6lkrehi 3337 19 intensive intensive JJ cord-335975-m6lkrehi 3337 20 care care NN cord-335975-m6lkrehi 3337 21 exceeds exceed VBZ cord-335975-m6lkrehi 3337 22 its -PRON- PRP$ cord-335975-m6lkrehi 3337 23 availability availability NN cord-335975-m6lkrehi 3337 24 in in IN cord-335975-m6lkrehi 3337 25 several several JJ cord-335975-m6lkrehi 3337 26 countries country NNS cord-335975-m6lkrehi 3337 27 . . . cord-335975-m6lkrehi 3338 1 As as IN cord-335975-m6lkrehi 3338 2 a a DT cord-335975-m6lkrehi 3338 3 consequence consequence NN cord-335975-m6lkrehi 3338 4 , , , cord-335975-m6lkrehi 3338 5 rationing ration VBG cord-335975-m6lkrehi 3338 6 intensive intensive JJ cord-335975-m6lkrehi 3338 7 care care NN cord-335975-m6lkrehi 3338 8 unit unit NN cord-335975-m6lkrehi 3338 9 ( ( -LRB- cord-335975-m6lkrehi 3338 10 ICU ICU NNP cord-335975-m6lkrehi 3338 11 ) ) -RRB- cord-335975-m6lkrehi 3338 12 beds bed NNS cord-335975-m6lkrehi 3338 13 is be VBZ cord-335975-m6lkrehi 3338 14 common common JJ cord-335975-m6lkrehi 3338 15 and and CC cord-335975-m6lkrehi 3338 16 often often RB cord-335975-m6lkrehi 3338 17 leads lead VBZ cord-335975-m6lkrehi 3338 18 to to IN cord-335975-m6lkrehi 3338 19 admission admission NN cord-335975-m6lkrehi 3338 20 refusal refusal NN cord-335975-m6lkrehi 3338 21 . . . cord-335975-m6lkrehi 3339 1 Purpose purpose NN cord-335975-m6lkrehi 3339 2 - - : cord-335975-m6lkrehi 3339 3 To to TO cord-335975-m6lkrehi 3339 4 report report VB cord-335975-m6lkrehi 3339 5 refusal refusal NN cord-335975-m6lkrehi 3339 6 determinants determinant NNS cord-335975-m6lkrehi 3339 7 and and CC cord-335975-m6lkrehi 3339 8 characteristics characteristic NNS cord-335975-m6lkrehi 3339 9 of of IN cord-335975-m6lkrehi 3339 10 patients patient NNS cord-335975-m6lkrehi 3339 11 associated associate VBN cord-335975-m6lkrehi 3339 12 with with IN cord-335975-m6lkrehi 3339 13 decisions decision NNS cord-335975-m6lkrehi 3339 14 to to TO cord-335975-m6lkrehi 3339 15 deny deny VB cord-335975-m6lkrehi 3339 16 ICU ICU NNP cord-335975-m6lkrehi 3339 17 admission admission NN cord-335975-m6lkrehi 3339 18 . . . cord-335975-m6lkrehi 3340 1 This this DT cord-335975-m6lkrehi 3340 2 study study NN cord-335975-m6lkrehi 3340 3 was be VBD cord-335975-m6lkrehi 3340 4 performed perform VBN cord-335975-m6lkrehi 3340 5 at at IN cord-335975-m6lkrehi 3340 6 the the DT cord-335975-m6lkrehi 3340 7 ICU ICU NNP cord-335975-m6lkrehi 3340 8 of of IN cord-335975-m6lkrehi 3340 9 Abderrahman Abderrahman NNP cord-335975-m6lkrehi 3340 10 Mami Mami NNP cord-335975-m6lkrehi 3340 11 Hospital Hospital NNP cord-335975-m6lkrehi 3340 12 , , , cord-335975-m6lkrehi 3340 13 a a DT cord-335975-m6lkrehi 3340 14 22-bed 22-bed CD cord-335975-m6lkrehi 3340 15 ICU ICU NNP cord-335975-m6lkrehi 3340 16 in in IN cord-335975-m6lkrehi 3340 17 Ariana Ariana NNP cord-335975-m6lkrehi 3340 18 , , , cord-335975-m6lkrehi 3340 19 Tunisia Tunisia NNP cord-335975-m6lkrehi 3340 20 . . . cord-335975-m6lkrehi 3341 1 It -PRON- PRP cord-335975-m6lkrehi 3341 2 was be VBD cord-335975-m6lkrehi 3341 3 a a DT cord-335975-m6lkrehi 3341 4 prospective prospective JJ cord-335975-m6lkrehi 3341 5 study study NN cord-335975-m6lkrehi 3341 6 enrolled enrol VBN cord-335975-m6lkrehi 3341 7 between between IN cord-335975-m6lkrehi 3341 8 1st 1st JJ cord-335975-m6lkrehi 3341 9 January January NNP cord-335975-m6lkrehi 3341 10 and and CC cord-335975-m6lkrehi 3341 11 31th 31th NN cord-335975-m6lkrehi 3341 12 December December NNP cord-335975-m6lkrehi 3341 13 2016 2016 CD cord-335975-m6lkrehi 3341 14 . . . cord-335975-m6lkrehi 3342 1 No no DT cord-335975-m6lkrehi 3342 2 predefined predefined JJ cord-335975-m6lkrehi 3342 3 admission admission NN cord-335975-m6lkrehi 3342 4 criteria criterion NNS cord-335975-m6lkrehi 3342 5 were be VBD cord-335975-m6lkrehi 3342 6 determined determine VBN cord-335975-m6lkrehi 3342 7 . . . cord-335975-m6lkrehi 3343 1 Decisions decision NNS cord-335975-m6lkrehi 3343 2 to to TO cord-335975-m6lkrehi 3343 3 admit admit VB cord-335975-m6lkrehi 3343 4 are be VBP cord-335975-m6lkrehi 3343 5 based base VBN cord-335975-m6lkrehi 3343 6 on on IN cord-335975-m6lkrehi 3343 7 a a DT cord-335975-m6lkrehi 3343 8 combination combination NN cord-335975-m6lkrehi 3343 9 of of IN cord-335975-m6lkrehi 3343 10 patient patient NN cord-335975-m6lkrehi 3343 11 - - HYPH cord-335975-m6lkrehi 3343 12 related relate VBN cord-335975-m6lkrehi 3343 13 factors factor NNS cord-335975-m6lkrehi 3343 14 , , , cord-335975-m6lkrehi 3343 15 severity severity NN cord-335975-m6lkrehi 3343 16 of of IN cord-335975-m6lkrehi 3343 17 illness illness NN cord-335975-m6lkrehi 3343 18 and and CC cord-335975-m6lkrehi 3343 19 bed bed NN cord-335975-m6lkrehi 3343 20 availability availability NN cord-335975-m6lkrehi 3343 21 . . . cord-335975-m6lkrehi 3344 1 All all DT cord-335975-m6lkrehi 3344 2 consecutive consecutive JJ cord-335975-m6lkrehi 3344 3 patients patient NNS cord-335975-m6lkrehi 3344 4 referred refer VBD cord-335975-m6lkrehi 3344 5 for for IN cord-335975-m6lkrehi 3344 6 admission admission NN cord-335975-m6lkrehi 3344 7 to to IN cord-335975-m6lkrehi 3344 8 ICU ICU NNP cord-335975-m6lkrehi 3344 9 during during IN cord-335975-m6lkrehi 3344 10 the the DT cord-335975-m6lkrehi 3344 11 study study NN cord-335975-m6lkrehi 3344 12 period period NN cord-335975-m6lkrehi 3344 13 were be VBD cord-335975-m6lkrehi 3344 14 included include VBN cord-335975-m6lkrehi 3344 15 . . . cord-335975-m6lkrehi 3345 1 2 2 CD cord-335975-m6lkrehi 3345 2 groups group NNS cord-335975-m6lkrehi 3345 3 were be VBD cord-335975-m6lkrehi 3345 4 defined define VBN cord-335975-m6lkrehi 3345 5 GI GI NNP cord-335975-m6lkrehi 3345 6 - - HYPH cord-335975-m6lkrehi 3345 7 Admitted admit VBN cord-335975-m6lkrehi 3345 8 patients patient NNS cord-335975-m6lkrehi 3345 9 and and CC cord-335975-m6lkrehi 3345 10 GII GII NNP cord-335975-m6lkrehi 3345 11 - - HYPH cord-335975-m6lkrehi 3345 12 refused refuse VBD cord-335975-m6lkrehi 3345 13 patients patient NNS cord-335975-m6lkrehi 3345 14 . . . cord-335975-m6lkrehi 3346 1 The the DT cord-335975-m6lkrehi 3346 2 reasons reason NNS cord-335975-m6lkrehi 3346 3 for for IN cord-335975-m6lkrehi 3346 4 refusal refusal NN cord-335975-m6lkrehi 3346 5 were be VBD cord-335975-m6lkrehi 3346 6 categorized categorize VBN cord-335975-m6lkrehi 3346 7 as as IN cord-335975-m6lkrehi 3346 8 follows follow VBZ cord-335975-m6lkrehi 3346 9 : : : cord-335975-m6lkrehi 3346 10 too too RB cord-335975-m6lkrehi 3346 11 well well RB cord-335975-m6lkrehi 3346 12 to to TO cord-335975-m6lkrehi 3346 13 benefit benefit VB cord-335975-m6lkrehi 3346 14 , , , cord-335975-m6lkrehi 3346 15 too too RB cord-335975-m6lkrehi 3346 16 sick sick JJ cord-335975-m6lkrehi 3346 17 to to TO cord-335975-m6lkrehi 3346 18 benefit benefit VB cord-335975-m6lkrehi 3346 19 , , , cord-335975-m6lkrehi 3346 20 patient patient NN cord-335975-m6lkrehi 3346 21 or or CC cord-335975-m6lkrehi 3346 22 family family NN cord-335975-m6lkrehi 3346 23 refusal refusal NN cord-335975-m6lkrehi 3346 24 , , , cord-335975-m6lkrehi 3346 25 necessity necessity NN cord-335975-m6lkrehi 3346 26 of of IN cord-335975-m6lkrehi 3346 27 other other JJ cord-335975-m6lkrehi 3346 28 exploration exploration NN cord-335975-m6lkrehi 3346 29 not not RB cord-335975-m6lkrehi 3346 30 available available JJ cord-335975-m6lkrehi 3346 31 in in IN cord-335975-m6lkrehi 3346 32 our -PRON- PRP$ cord-335975-m6lkrehi 3346 33 institution institution NN cord-335975-m6lkrehi 3346 34 and and CC cord-335975-m6lkrehi 3346 35 unit unit NN cord-335975-m6lkrehi 3346 36 too too RB cord-335975-m6lkrehi 3346 37 busy busy JJ cord-335975-m6lkrehi 3346 38 . . . cord-335975-m6lkrehi 3347 1 Results result NNS cord-335975-m6lkrehi 3347 2 : : : cord-335975-m6lkrehi 3348 1 During during IN cord-335975-m6lkrehi 3348 2 the the DT cord-335975-m6lkrehi 3348 3 study study NN cord-335975-m6lkrehi 3348 4 period period NN cord-335975-m6lkrehi 3348 5 , , , cord-335975-m6lkrehi 3348 6 ICU ICU NNP cord-335975-m6lkrehi 3348 7 admission admission NN cord-335975-m6lkrehi 3348 8 was be VBD cord-335975-m6lkrehi 3348 9 requested request VBN cord-335975-m6lkrehi 3348 10 for for IN cord-335975-m6lkrehi 3348 11 1081 1081 CD cord-335975-m6lkrehi 3348 12 patients patient NNS cord-335975-m6lkrehi 3348 13 of of IN cord-335975-m6lkrehi 3348 14 whom whom WP cord-335975-m6lkrehi 3348 15 590 590 CD cord-335975-m6lkrehi 3348 16 were be VBD cord-335975-m6lkrehi 3348 17 admitted admit VBN cord-335975-m6lkrehi 3348 18 ( ( -LRB- cord-335975-m6lkrehi 3348 19 54 54 CD cord-335975-m6lkrehi 3348 20 % % NN cord-335975-m6lkrehi 3348 21 ) ) -RRB- cord-335975-m6lkrehi 3348 22 . . . cord-335975-m6lkrehi 3349 1 Of of IN cord-335975-m6lkrehi 3349 2 the the DT cord-335975-m6lkrehi 3349 3 491 491 CD cord-335975-m6lkrehi 3349 4 patients patient NNS cord-335975-m6lkrehi 3349 5 refused refuse VBD cord-335975-m6lkrehi 3349 6 , , , cord-335975-m6lkrehi 3349 7 only only RB cord-335975-m6lkrehi 3349 8 41 41 CD cord-335975-m6lkrehi 3349 9 were be VBD cord-335975-m6lkrehi 3349 10 admitted admit VBN cord-335975-m6lkrehi 3349 11 to to IN cord-335975-m6lkrehi 3349 12 ICU ICU NNP cord-335975-m6lkrehi 3349 13 later later RB cord-335975-m6lkrehi 3349 14 . . . cord-335975-m6lkrehi 3350 1 Refusal refusal NN cord-335975-m6lkrehi 3350 2 of of IN cord-335975-m6lkrehi 3350 3 ICU ICU NNP cord-335975-m6lkrehi 3350 4 admission admission NN cord-335975-m6lkrehi 3350 5 came come VBD cord-335975-m6lkrehi 3350 6 in in IN cord-335975-m6lkrehi 3350 7 23 23 CD cord-335975-m6lkrehi 3350 8 % % NN cord-335975-m6lkrehi 3350 9 of of IN cord-335975-m6lkrehi 3350 10 cases case NNS cord-335975-m6lkrehi 3350 11 from from IN cord-335975-m6lkrehi 3350 12 the the DT cord-335975-m6lkrehi 3350 13 emergency emergency NN cord-335975-m6lkrehi 3350 14 room room NN cord-335975-m6lkrehi 3350 15 and and CC cord-335975-m6lkrehi 3350 16 wards ward NNS cord-335975-m6lkrehi 3350 17 of of IN cord-335975-m6lkrehi 3350 18 our -PRON- PRP$ cord-335975-m6lkrehi 3350 19 hospital hospital NN cord-335975-m6lkrehi 3350 20 , , , cord-335975-m6lkrehi 3350 21 in in IN cord-335975-m6lkrehi 3350 22 65 65 CD cord-335975-m6lkrehi 3350 23 % % NN cord-335975-m6lkrehi 3350 24 from from IN cord-335975-m6lkrehi 3350 25 other other JJ cord-335975-m6lkrehi 3350 26 hospitals hospital NNS cord-335975-m6lkrehi 3350 27 of of IN cord-335975-m6lkrehi 3350 28 whom whom WP cord-335975-m6lkrehi 3350 29 30 30 CD cord-335975-m6lkrehi 3350 30 % % NN cord-335975-m6lkrehi 3350 31 without without IN cord-335975-m6lkrehi 3350 32 ICU ICU NNP cord-335975-m6lkrehi 3350 33 . . . cord-335975-m6lkrehi 3351 1 Reasons reason NNS cord-335975-m6lkrehi 3351 2 of of IN cord-335975-m6lkrehi 3351 3 refusal refusal NN cord-335975-m6lkrehi 3351 4 were be VBD cord-335975-m6lkrehi 3351 5 no no DT cord-335975-m6lkrehi 3351 6 beds bed NNS cord-335975-m6lkrehi 3351 7 availability availability NN cord-335975-m6lkrehi 3351 8 ( ( -LRB- cord-335975-m6lkrehi 3351 9 76.2 76.2 CD cord-335975-m6lkrehi 3351 10 % % NN cord-335975-m6lkrehi 3351 11 ) ) -RRB- cord-335975-m6lkrehi 3351 12 , , , cord-335975-m6lkrehi 3351 13 too too RB cord-335975-m6lkrehi 3351 14 sick sick JJ cord-335975-m6lkrehi 3351 15 to to TO cord-335975-m6lkrehi 3351 16 benefit benefit VB cord-335975-m6lkrehi 3351 17 from from IN cord-335975-m6lkrehi 3351 18 ICU ICU NNP cord-335975-m6lkrehi 3351 19 ( ( -LRB- cord-335975-m6lkrehi 3351 20 13 13 CD cord-335975-m6lkrehi 3351 21 % % NN cord-335975-m6lkrehi 3351 22 ) ) -RRB- cord-335975-m6lkrehi 3351 23 , , , cord-335975-m6lkrehi 3351 24 too too RB cord-335975-m6lkrehi 3351 25 well well RB cord-335975-m6lkrehi 3351 26 ( ( -LRB- cord-335975-m6lkrehi 3351 27 9.4 9.4 CD cord-335975-m6lkrehi 3351 28 % % NN cord-335975-m6lkrehi 3351 29 ) ) -RRB- cord-335975-m6lkrehi 3351 30 and and CC cord-335975-m6lkrehi 3351 31 necessity necessity NN cord-335975-m6lkrehi 3351 32 of of IN cord-335975-m6lkrehi 3351 33 other other JJ cord-335975-m6lkrehi 3351 34 exploration exploration NN cord-335975-m6lkrehi 3351 35 ( ( -LRB- cord-335975-m6lkrehi 3351 36 1.4 1.4 CD cord-335975-m6lkrehi 3351 37 % % NN cord-335975-m6lkrehi 3351 38 ) ) -RRB- cord-335975-m6lkrehi 3351 39 . . . cord-335975-m6lkrehi 3352 1 No no DT cord-335975-m6lkrehi 3352 2 differences difference NNS cord-335975-m6lkrehi 3352 3 in in IN cord-335975-m6lkrehi 3352 4 demographic demographic JJ cord-335975-m6lkrehi 3352 5 characteristic characteristic NN cord-335975-m6lkrehi 3352 6 between between IN cord-335975-m6lkrehi 3352 7 the the DT cord-335975-m6lkrehi 3352 8 two two CD cord-335975-m6lkrehi 3352 9 groups group NNS cord-335975-m6lkrehi 3352 10 were be VBD cord-335975-m6lkrehi 3352 11 noted note VBN cord-335975-m6lkrehi 3352 12 . . . cord-335975-m6lkrehi 3353 1 Among among IN cord-335975-m6lkrehi 3353 2 the the DT cord-335975-m6lkrehi 3353 3 refused refuse VBN cord-335975-m6lkrehi 3353 4 patients patient NNS cord-335975-m6lkrehi 3353 5 , , , cord-335975-m6lkrehi 3353 6 when when WRB cord-335975-m6lkrehi 3353 7 compared compare VBN cord-335975-m6lkrehi 3353 8 with with IN cord-335975-m6lkrehi 3353 9 admitted admit VBN cord-335975-m6lkrehi 3353 10 patients patient NNS cord-335975-m6lkrehi 3353 11 , , , cord-335975-m6lkrehi 3353 12 we -PRON- PRP cord-335975-m6lkrehi 3353 13 found find VBD cord-335975-m6lkrehi 3353 14 higher high JJR cord-335975-m6lkrehi 3353 15 proportions proportion NNS cord-335975-m6lkrehi 3353 16 of of IN cord-335975-m6lkrehi 3353 17 hematologic hematologic JJ cord-335975-m6lkrehi 3353 18 malignancies malignancy NNS cord-335975-m6lkrehi 3353 19 ( ( -LRB- cord-335975-m6lkrehi 3353 20 p p NN cord-335975-m6lkrehi 3353 21 < < XX cord-335975-m6lkrehi 3353 22 0.01 0.01 CD cord-335975-m6lkrehi 3353 23 ) ) -RRB- cord-335975-m6lkrehi 3353 24 and and CC cord-335975-m6lkrehi 3353 25 cardiocirculatory cardiocirculatory NN cord-335975-m6lkrehi 3353 26 arrest arrest NN cord-335975-m6lkrehi 3353 27 ( ( -LRB- cord-335975-m6lkrehi 3353 28 p p NN cord-335975-m6lkrehi 3353 29 = = SYM cord-335975-m6lkrehi 3353 30 0.01 0.01 CD cord-335975-m6lkrehi 3353 31 ) ) -RRB- cord-335975-m6lkrehi 3353 32 . . . cord-335975-m6lkrehi 3354 1 On on IN cord-335975-m6lkrehi 3354 2 the the DT cord-335975-m6lkrehi 3354 3 other other JJ cord-335975-m6lkrehi 3354 4 hand hand NN cord-335975-m6lkrehi 3354 5 , , , cord-335975-m6lkrehi 3354 6 admitted admit VBD cord-335975-m6lkrehi 3354 7 patients patient NNS cord-335975-m6lkrehi 3354 8 were be VBD cord-335975-m6lkrehi 3354 9 more more RBR cord-335975-m6lkrehi 3354 10 likely likely JJ cord-335975-m6lkrehi 3354 11 to to TO cord-335975-m6lkrehi 3354 12 have have VB cord-335975-m6lkrehi 3354 13 cardio cardio JJ cord-335975-m6lkrehi 3354 14 - - HYPH cord-335975-m6lkrehi 3354 15 respiratory respiratory JJ cord-335975-m6lkrehi 3354 16 comorbidities comorbiditie NNS cord-335975-m6lkrehi 3354 17 ( ( -LRB- cord-335975-m6lkrehi 3354 18 437/590 437/590 CD cord-335975-m6lkrehi 3354 19 vs. vs. IN cord-335975-m6lkrehi 3354 20 297/491 297/491 CD cord-335975-m6lkrehi 3354 21 , , , cord-335975-m6lkrehi 3354 22 p p NN cord-335975-m6lkrehi 3354 23 = = SYM cord-335975-m6lkrehi 3354 24 0.01 0.01 CD cord-335975-m6lkrehi 3354 25 ) ) -RRB- cord-335975-m6lkrehi 3354 26 and and CC cord-335975-m6lkrehi 3354 27 more more JJR cord-335975-m6lkrehi 3354 28 need need NN cord-335975-m6lkrehi 3354 29 to to IN cord-335975-m6lkrehi 3354 30 mechanical mechanical JJ cord-335975-m6lkrehi 3354 31 ventilatory ventilatory JJ cord-335975-m6lkrehi 3354 32 support support NN cord-335975-m6lkrehi 3354 33 ( ( -LRB- cord-335975-m6lkrehi 3354 34 404 404 CD cord-335975-m6lkrehi 3354 35 590 590 CD cord-335975-m6lkrehi 3354 36 vs. vs. NN cord-335975-m6lkrehi 3354 37 166 166 CD cord-335975-m6lkrehi 3354 38 491 491 CD cord-335975-m6lkrehi 3354 39 , , , cord-335975-m6lkrehi 3354 40 p p NN cord-335975-m6lkrehi 3354 41 = = SYM cord-335975-m6lkrehi 3354 42 0.016 0.016 CD cord-335975-m6lkrehi 3354 43 ) ) -RRB- cord-335975-m6lkrehi 3354 44 . . . cord-335975-m6lkrehi 3355 1 Conclusion conclusion NN cord-335975-m6lkrehi 3355 2 : : : cord-335975-m6lkrehi 3356 1 Our -PRON- PRP$ cord-335975-m6lkrehi 3356 2 study study NN cord-335975-m6lkrehi 3356 3 confirms confirm VBZ cord-335975-m6lkrehi 3356 4 that that IN cord-335975-m6lkrehi 3356 5 ICU ICU NNP cord-335975-m6lkrehi 3356 6 refusal refusal NN cord-335975-m6lkrehi 3356 7 rate rate NN cord-335975-m6lkrehi 3356 8 still still RB cord-335975-m6lkrehi 3356 9 high high JJ cord-335975-m6lkrehi 3356 10 . . . cord-335975-m6lkrehi 3357 1 It -PRON- PRP cord-335975-m6lkrehi 3357 2 depends depend VBZ cord-335975-m6lkrehi 3357 3 on on IN cord-335975-m6lkrehi 3357 4 both both DT cord-335975-m6lkrehi 3357 5 ICU ICU NNP cord-335975-m6lkrehi 3357 6 organization organization NN cord-335975-m6lkrehi 3357 7 and and CC cord-335975-m6lkrehi 3357 8 patient patient JJ cord-335975-m6lkrehi 3357 9 characteristics characteristic NNS cord-335975-m6lkrehi 3357 10 . . . cord-335975-m6lkrehi 3358 1 Acute acute JJ cord-335975-m6lkrehi 3358 2 heart heart NN cord-335975-m6lkrehi 3358 3 failure failure NN cord-335975-m6lkrehi 3358 4 syndroms syndrom NNS cord-335975-m6lkrehi 3358 5 in in IN cord-335975-m6lkrehi 3358 6 intensive intensive JJ cord-335975-m6lkrehi 3358 7 care care NN cord-335975-m6lkrehi 3358 8 : : : cord-335975-m6lkrehi 3358 9 clinical clinical JJ cord-335975-m6lkrehi 3358 10 features feature NNS cord-335975-m6lkrehi 3358 11 , , , cord-335975-m6lkrehi 3358 12 management management NN cord-335975-m6lkrehi 3358 13 and and CC cord-335975-m6lkrehi 3358 14 outcome outcome NN cord-335975-m6lkrehi 3358 15 Jamoussi Jamoussi NNP cord-335975-m6lkrehi 3358 16 Amira Amira NNP cord-335975-m6lkrehi 3358 17 1 1 CD cord-335975-m6lkrehi 3358 18 , , , cord-335975-m6lkrehi 3358 19 Ajili Ajili NNP cord-335975-m6lkrehi 3358 20 Achraf Achraf NNP cord-335975-m6lkrehi 3358 21 1 1 CD cord-335975-m6lkrehi 3358 22 , , , cord-335975-m6lkrehi 3358 23 Merhebene Merhebene NNP cord-335975-m6lkrehi 3358 24 Takoua Takoua NNP cord-335975-m6lkrehi 3358 25 Introduction introduction NN cord-335975-m6lkrehi 3358 26 : : : cord-335975-m6lkrehi 3358 27 Classification classification NN cord-335975-m6lkrehi 3358 28 of of IN cord-335975-m6lkrehi 3358 29 acute acute JJ cord-335975-m6lkrehi 3358 30 heart heart NN cord-335975-m6lkrehi 3358 31 failure failure NN cord-335975-m6lkrehi 3358 32 ( ( -LRB- cord-335975-m6lkrehi 3358 33 AHF AHF NNP cord-335975-m6lkrehi 3358 34 ) ) -RRB- cord-335975-m6lkrehi 3358 35 into into IN cord-335975-m6lkrehi 3358 36 5 5 CD cord-335975-m6lkrehi 3358 37 clinical clinical JJ cord-335975-m6lkrehi 3358 38 scenari scenari NN cord-335975-m6lkrehi 3358 39 ( ( -LRB- cord-335975-m6lkrehi 3358 40 CS CS NNP cord-335975-m6lkrehi 3358 41 ) ) -RRB- cord-335975-m6lkrehi 3358 42 was be VBD cord-335975-m6lkrehi 3358 43 first first RB cord-335975-m6lkrehi 3358 44 proposed propose VBN cord-335975-m6lkrehi 3358 45 to to TO cord-335975-m6lkrehi 3358 46 facilitate facilitate VB cord-335975-m6lkrehi 3358 47 early early JJ cord-335975-m6lkrehi 3358 48 management management NN cord-335975-m6lkrehi 3358 49 ( ( -LRB- cord-335975-m6lkrehi 3358 50 1 1 CD cord-335975-m6lkrehi 3358 51 ) ) -RRB- cord-335975-m6lkrehi 3358 52 . . . cord-335975-m6lkrehi 3359 1 A a DT cord-335975-m6lkrehi 3359 2 decade decade NN cord-335975-m6lkrehi 3359 3 after after IN cord-335975-m6lkrehi 3359 4 implementation implementation NN cord-335975-m6lkrehi 3359 5 of of IN cord-335975-m6lkrehi 3359 6 this this DT cord-335975-m6lkrehi 3359 7 approach approach NN cord-335975-m6lkrehi 3359 8 , , , cord-335975-m6lkrehi 3359 9 epidemiological epidemiological JJ cord-335975-m6lkrehi 3359 10 and and CC cord-335975-m6lkrehi 3359 11 evolutive evolutive JJ cord-335975-m6lkrehi 3359 12 data datum NNS cord-335975-m6lkrehi 3359 13 based base VBN cord-335975-m6lkrehi 3359 14 on on IN cord-335975-m6lkrehi 3359 15 this this DT cord-335975-m6lkrehi 3359 16 classification classification NN cord-335975-m6lkrehi 3359 17 are be VBP cord-335975-m6lkrehi 3359 18 interesting interesting JJ cord-335975-m6lkrehi 3359 19 to to TO cord-335975-m6lkrehi 3359 20 investigate investigate VB cord-335975-m6lkrehi 3359 21 . . . cord-335975-m6lkrehi 3360 1 That that DT cord-335975-m6lkrehi 3360 2 is be VBZ cord-335975-m6lkrehi 3360 3 why why WRB cord-335975-m6lkrehi 3360 4 we -PRON- PRP cord-335975-m6lkrehi 3360 5 aim aim VBP cord-335975-m6lkrehi 3360 6 to to TO cord-335975-m6lkrehi 3360 7 describe describe VB cord-335975-m6lkrehi 3360 8 frequencies frequency NNS cord-335975-m6lkrehi 3360 9 , , , cord-335975-m6lkrehi 3360 10 management management NN cord-335975-m6lkrehi 3360 11 and and CC cord-335975-m6lkrehi 3360 12 mortality mortality NN cord-335975-m6lkrehi 3360 13 of of IN cord-335975-m6lkrehi 3360 14 each each DT cord-335975-m6lkrehi 3360 15 AHF AHF NNP cord-335975-m6lkrehi 3360 16 syndrom syndrom NN cord-335975-m6lkrehi 3360 17 in in IN cord-335975-m6lkrehi 3360 18 intensive intensive JJ cord-335975-m6lkrehi 3360 19 care care NN cord-335975-m6lkrehi 3360 20 . . . cord-335975-m6lkrehi 3361 1 A a DT cord-335975-m6lkrehi 3361 2 prospective prospective JJ cord-335975-m6lkrehi 3361 3 study study NN cord-335975-m6lkrehi 3361 4 of of IN cord-335975-m6lkrehi 3361 5 patients patient NNS cord-335975-m6lkrehi 3361 6 > > XX cord-335975-m6lkrehi 3361 7 18 18 CD cord-335975-m6lkrehi 3361 8 years year NNS cord-335975-m6lkrehi 3361 9 with with IN cord-335975-m6lkrehi 3361 10 AHF AHF NNP cord-335975-m6lkrehi 3361 11 admitted admit VBD cord-335975-m6lkrehi 3361 12 to to IN cord-335975-m6lkrehi 3361 13 the the DT cord-335975-m6lkrehi 3361 14 medical medical JJ cord-335975-m6lkrehi 3361 15 intensive intensive JJ cord-335975-m6lkrehi 3361 16 care care NN cord-335975-m6lkrehi 3361 17 unit unit NN cord-335975-m6lkrehi 3361 18 ( ( -LRB- cord-335975-m6lkrehi 3361 19 ICU ICU NNP cord-335975-m6lkrehi 3361 20 ) ) -RRB- cord-335975-m6lkrehi 3361 21 of of IN cord-335975-m6lkrehi 3361 22 Abderrahmen Abderrahmen NNP cord-335975-m6lkrehi 3361 23 Mami Mami NNP cord-335975-m6lkrehi 3361 24 hospital hospital NN cord-335975-m6lkrehi 3361 25 from from IN cord-335975-m6lkrehi 3361 26 January January NNP cord-335975-m6lkrehi 3361 27 2017 2017 CD cord-335975-m6lkrehi 3361 28 to to IN cord-335975-m6lkrehi 3361 29 August August NNP cord-335975-m6lkrehi 3361 30 2017 2017 CD cord-335975-m6lkrehi 3361 31 was be VBD cord-335975-m6lkrehi 3361 32 conducted conduct VBN cord-335975-m6lkrehi 3361 33 . . . cord-335975-m6lkrehi 3362 1 Patients patient NNS cord-335975-m6lkrehi 3362 2 were be VBD cord-335975-m6lkrehi 3362 3 classified classify VBN cord-335975-m6lkrehi 3362 4 according accord VBG cord-335975-m6lkrehi 3362 5 to to IN cord-335975-m6lkrehi 3362 6 the the DT cord-335975-m6lkrehi 3362 7 5 5 CD cord-335975-m6lkrehi 3362 8 clinical clinical JJ cord-335975-m6lkrehi 3362 9 scenari scenari NN cord-335975-m6lkrehi 3362 10 ( ( -LRB- cord-335975-m6lkrehi 3362 11 1 1 CD cord-335975-m6lkrehi 3362 12 ) ) -RRB- cord-335975-m6lkrehi 3362 13 . . . cord-335975-m6lkrehi 3363 1 Clinical clinical JJ cord-335975-m6lkrehi 3363 2 , , , cord-335975-m6lkrehi 3363 3 therapeutic therapeutic JJ cord-335975-m6lkrehi 3363 4 and and CC cord-335975-m6lkrehi 3363 5 outcome outcome NN cord-335975-m6lkrehi 3363 6 findings finding NNS cord-335975-m6lkrehi 3363 7 were be VBD cord-335975-m6lkrehi 3363 8 recorded record VBN cord-335975-m6lkrehi 3363 9 . . . cord-335975-m6lkrehi 3364 1 Results result NNS cord-335975-m6lkrehi 3364 2 : : : cord-335975-m6lkrehi 3365 1 During during IN cord-335975-m6lkrehi 3365 2 the the DT cord-335975-m6lkrehi 3365 3 study study NN cord-335975-m6lkrehi 3365 4 period period NN cord-335975-m6lkrehi 3365 5 ( ( -LRB- cord-335975-m6lkrehi 3365 6 8 8 CD cord-335975-m6lkrehi 3365 7 months month NNS cord-335975-m6lkrehi 3365 8 ) ) -RRB- cord-335975-m6lkrehi 3365 9 , , , cord-335975-m6lkrehi 3365 10 we -PRON- PRP cord-335975-m6lkrehi 3365 11 admitted admit VBD cord-335975-m6lkrehi 3365 12 291 291 CD cord-335975-m6lkrehi 3365 13 patients patient NNS cord-335975-m6lkrehi 3365 14 in in IN cord-335975-m6lkrehi 3365 15 ICU ICU NNP cord-335975-m6lkrehi 3365 16 from from IN cord-335975-m6lkrehi 3365 17 whom whom WP cord-335975-m6lkrehi 3365 18 43 43 CD cord-335975-m6lkrehi 3365 19 ( ( -LRB- cord-335975-m6lkrehi 3365 20 14.8 14.8 CD cord-335975-m6lkrehi 3365 21 % % NN cord-335975-m6lkrehi 3365 22 ) ) -RRB- cord-335975-m6lkrehi 3365 23 presented present VBN cord-335975-m6lkrehi 3365 24 with with IN cord-335975-m6lkrehi 3365 25 AHF AHF NNP cord-335975-m6lkrehi 3365 26 and and CC cord-335975-m6lkrehi 3365 27 then then RB cord-335975-m6lkrehi 3365 28 enrolled enrol VBD cord-335975-m6lkrehi 3365 29 . . . cord-335975-m6lkrehi 3366 1 The the DT cord-335975-m6lkrehi 3366 2 median median JJ cord-335975-m6lkrehi 3366 3 age age NN cord-335975-m6lkrehi 3366 4 was be VBD cord-335975-m6lkrehi 3366 5 of of IN cord-335975-m6lkrehi 3366 6 63 63 CD cord-335975-m6lkrehi 3366 7 ± ± CD cord-335975-m6lkrehi 3366 8 18.6 18.6 CD cord-335975-m6lkrehi 3366 9 years year NNS cord-335975-m6lkrehi 3366 10 and and CC cord-335975-m6lkrehi 3366 11 sex sex NN cord-335975-m6lkrehi 3366 12 - - HYPH cord-335975-m6lkrehi 3366 13 ratio ratio NN cord-335975-m6lkrehi 3366 14 1.05 1.05 CD cord-335975-m6lkrehi 3366 15 . . . cord-335975-m6lkrehi 3367 1 A a DT cord-335975-m6lkrehi 3367 2 medical medical JJ cord-335975-m6lkrehi 3367 3 history history NN cord-335975-m6lkrehi 3367 4 of of IN cord-335975-m6lkrehi 3367 5 COPD COPD NNP cord-335975-m6lkrehi 3367 6 ( ( -LRB- cord-335975-m6lkrehi 3367 7 20.9 20.9 CD cord-335975-m6lkrehi 3367 8 % % NN cord-335975-m6lkrehi 3367 9 ) ) -RRB- cord-335975-m6lkrehi 3367 10 , , , cord-335975-m6lkrehi 3367 11 hypertension hypertension NN cord-335975-m6lkrehi 3367 12 ( ( -LRB- cord-335975-m6lkrehi 3367 13 46.5 46.5 CD cord-335975-m6lkrehi 3367 14 % % NN cord-335975-m6lkrehi 3367 15 ) ) -RRB- cord-335975-m6lkrehi 3367 16 , , , cord-335975-m6lkrehi 3367 17 diabetes diabetes NN cord-335975-m6lkrehi 3367 18 ( ( -LRB- cord-335975-m6lkrehi 3367 19 20.9 20.9 CD cord-335975-m6lkrehi 3367 20 % % NN cord-335975-m6lkrehi 3367 21 ) ) -RRB- cord-335975-m6lkrehi 3367 22 , , , cord-335975-m6lkrehi 3367 23 ischemic ischemic JJ cord-335975-m6lkrehi 3367 24 cardiopathy cardiopathy NN cord-335975-m6lkrehi 3367 25 ( ( -LRB- cord-335975-m6lkrehi 3367 26 28 28 CD cord-335975-m6lkrehi 3367 27 % % NN cord-335975-m6lkrehi 3367 28 ) ) -RRB- cord-335975-m6lkrehi 3367 29 and and CC cord-335975-m6lkrehi 3367 30 valvular valvular JJ cord-335975-m6lkrehi 3367 31 cardiopathy cardiopathy NN cord-335975-m6lkrehi 3367 32 ( ( -LRB- cord-335975-m6lkrehi 3367 33 16.3 16.3 CD cord-335975-m6lkrehi 3367 34 % % NN cord-335975-m6lkrehi 3367 35 ) ) -RRB- cord-335975-m6lkrehi 3367 36 were be VBD cord-335975-m6lkrehi 3367 37 noticed notice VBN cord-335975-m6lkrehi 3367 38 . . . cord-335975-m6lkrehi 3368 1 At at IN cord-335975-m6lkrehi 3368 2 admission admission NN cord-335975-m6lkrehi 3368 3 , , , cord-335975-m6lkrehi 3368 4 severity severity NN cord-335975-m6lkrehi 3368 5 assessement assessement NN cord-335975-m6lkrehi 3368 6 scores score NNS cord-335975-m6lkrehi 3368 7 were be VBD cord-335975-m6lkrehi 3368 8 : : : cord-335975-m6lkrehi 3368 9 median median JJ cord-335975-m6lkrehi 3368 10 APACHE APACHE NNP cord-335975-m6lkrehi 3368 11 II II NNP cord-335975-m6lkrehi 3368 12 18.5 18.5 CD cord-335975-m6lkrehi 3368 13 ± ± NNP cord-335975-m6lkrehi 3368 14 10.5 10.5 CD cord-335975-m6lkrehi 3368 15 and and CC cord-335975-m6lkrehi 3368 16 median median JJ cord-335975-m6lkrehi 3368 17 SAPS SAPS NNP cord-335975-m6lkrehi 3368 18 II II NNP cord-335975-m6lkrehi 3368 19 30 30 CD cord-335975-m6lkrehi 3368 20 ± ± CD cord-335975-m6lkrehi 3368 21 17.6 17.6 CD cord-335975-m6lkrehi 3368 22 . . . cord-335975-m6lkrehi 3369 1 Clinical clinical JJ cord-335975-m6lkrehi 3369 2 and and CC cord-335975-m6lkrehi 3369 3 evolutive evolutive JJ cord-335975-m6lkrehi 3369 4 characteristics characteristic NNS cord-335975-m6lkrehi 3369 5 according accord VBG cord-335975-m6lkrehi 3369 6 to to IN cord-335975-m6lkrehi 3369 7 clinical clinical JJ cord-335975-m6lkrehi 3369 8 scenari scenari NN cord-335975-m6lkrehi 3369 9 are be VBP cord-335975-m6lkrehi 3369 10 listed list VBN cord-335975-m6lkrehi 3369 11 in in IN cord-335975-m6lkrehi 3369 12 Table Table NNP cord-335975-m6lkrehi 3369 13 1 1 CD cord-335975-m6lkrehi 3369 14 . . . cord-335975-m6lkrehi 3370 1 Conclusion conclusion NN cord-335975-m6lkrehi 3370 2 : : : cord-335975-m6lkrehi 3371 1 CS CS NNP cord-335975-m6lkrehi 3371 2 2 2 CD cord-335975-m6lkrehi 3371 3 and and CC cord-335975-m6lkrehi 3371 4 CS CS NNP cord-335975-m6lkrehi 3371 5 1 1 CD cord-335975-m6lkrehi 3371 6 are be VBP cord-335975-m6lkrehi 3371 7 the the DT cord-335975-m6lkrehi 3371 8 most most RBS cord-335975-m6lkrehi 3371 9 frequent frequent JJ cord-335975-m6lkrehi 3371 10 AHF AHF NNP cord-335975-m6lkrehi 3371 11 syndroms syndrom NNS cord-335975-m6lkrehi 3371 12 in in IN cord-335975-m6lkrehi 3371 13 ICU ICU NNP cord-335975-m6lkrehi 3371 14 and and CC cord-335975-m6lkrehi 3371 15 also also RB cord-335975-m6lkrehi 3371 16 have have VB cord-335975-m6lkrehi 3371 17 the the DT cord-335975-m6lkrehi 3371 18 best good JJS cord-335975-m6lkrehi 3371 19 outcome outcome NN cord-335975-m6lkrehi 3371 20 . . . cord-335975-m6lkrehi 3372 1 Introduction introduction NN cord-335975-m6lkrehi 3372 2 : : : cord-335975-m6lkrehi 3373 1 In in IN cord-335975-m6lkrehi 3373 2 cardiac cardiac JJ cord-335975-m6lkrehi 3373 3 arrest arrest NN cord-335975-m6lkrehi 3373 4 patients patient NNS cord-335975-m6lkrehi 3373 5 resuscitated resuscitate VBD cord-335975-m6lkrehi 3373 6 from from IN cord-335975-m6lkrehi 3373 7 an an DT cord-335975-m6lkrehi 3373 8 ischemic ischemic JJ cord-335975-m6lkrehi 3373 9 ventricular ventricular JJ cord-335975-m6lkrehi 3373 10 fibrillation fibrillation NN cord-335975-m6lkrehi 3373 11 or or CC cord-335975-m6lkrehi 3373 12 tachycardia tachycardia NN cord-335975-m6lkrehi 3373 13 ( ( -LRB- cord-335975-m6lkrehi 3373 14 VF VF NNP cord-335975-m6lkrehi 3373 15 / / SYM cord-335975-m6lkrehi 3373 16 VT VT NNP cord-335975-m6lkrehi 3373 17 ) ) -RRB- cord-335975-m6lkrehi 3373 18 , , , cord-335975-m6lkrehi 3373 19 both both DT cord-335975-m6lkrehi 3373 20 incidence incidence NN cord-335975-m6lkrehi 3373 21 and and CC cord-335975-m6lkrehi 3373 22 risk risk NN cord-335975-m6lkrehi 3373 23 factors factor NNS cord-335975-m6lkrehi 3373 24 of of IN cord-335975-m6lkrehi 3373 25 recurrent recurrent JJ cord-335975-m6lkrehi 3373 26 severe severe JJ cord-335975-m6lkrehi 3373 27 arrhythmia arrhythmia NN cord-335975-m6lkrehi 3373 28 are be VBP cord-335975-m6lkrehi 3373 29 unclear unclear JJ cord-335975-m6lkrehi 3373 30 . . . cord-335975-m6lkrehi 3374 1 Whether whether IN cord-335975-m6lkrehi 3374 2 it -PRON- PRP cord-335975-m6lkrehi 3374 3 is be VBZ cord-335975-m6lkrehi 3374 4 useful useful JJ cord-335975-m6lkrehi 3374 5 to to TO cord-335975-m6lkrehi 3374 6 give give VB cord-335975-m6lkrehi 3374 7 a a DT cord-335975-m6lkrehi 3374 8 prophylactic prophylactic JJ cord-335975-m6lkrehi 3374 9 anti anti JJ cord-335975-m6lkrehi 3374 10 - - JJ cord-335975-m6lkrehi 3374 11 arrhythmic arrhythmic JJ cord-335975-m6lkrehi 3374 12 ( ( -LRB- cord-335975-m6lkrehi 3374 13 AA AA NNP cord-335975-m6lkrehi 3374 14 ) ) -RRB- cord-335975-m6lkrehi 3374 15 treatment treatment NN cord-335975-m6lkrehi 3374 16 during during IN cord-335975-m6lkrehi 3374 17 the the DT cord-335975-m6lkrehi 3374 18 first first JJ cord-335975-m6lkrehi 3374 19 hours hour NNS cord-335975-m6lkrehi 3374 20 and and CC cord-335975-m6lkrehi 3374 21 days day NNS cord-335975-m6lkrehi 3374 22 is be VBZ cord-335975-m6lkrehi 3374 23 debated debate VBN cord-335975-m6lkrehi 3374 24 , , , cord-335975-m6lkrehi 3374 25 particularly particularly RB cord-335975-m6lkrehi 3374 26 when when WRB cord-335975-m6lkrehi 3374 27 a a DT cord-335975-m6lkrehi 3374 28 successful successful JJ cord-335975-m6lkrehi 3374 29 coronary coronary JJ cord-335975-m6lkrehi 3374 30 reperfusion reperfusion NN cord-335975-m6lkrehi 3374 31 was be VBD cord-335975-m6lkrehi 3374 32 provided provide VBN cord-335975-m6lkrehi 3374 33 . . . cord-335975-m6lkrehi 3375 1 We -PRON- PRP cord-335975-m6lkrehi 3375 2 aimed aim VBD cord-335975-m6lkrehi 3375 3 to to TO cord-335975-m6lkrehi 3375 4 evaluate evaluate VB cord-335975-m6lkrehi 3375 5 the the DT cord-335975-m6lkrehi 3375 6 incidence incidence NN cord-335975-m6lkrehi 3375 7 of of IN cord-335975-m6lkrehi 3375 8 severe severe JJ cord-335975-m6lkrehi 3375 9 arrhythmia arrhythmia NN cord-335975-m6lkrehi 3375 10 in in IN cord-335975-m6lkrehi 3375 11 patients patient NNS cord-335975-m6lkrehi 3375 12 resuscitated resuscitate VBN cord-335975-m6lkrehi 3375 13 from from IN cord-335975-m6lkrehi 3375 14 an an DT cord-335975-m6lkrehi 3375 15 ischemic ischemic JJ cord-335975-m6lkrehi 3375 16 VF vf NN cord-335975-m6lkrehi 3375 17 VT VT NNP cord-335975-m6lkrehi 3375 18 and and CC cord-335975-m6lkrehi 3375 19 to to TO cord-335975-m6lkrehi 3375 20 identify identify VB cord-335975-m6lkrehi 3375 21 risk risk NN cord-335975-m6lkrehi 3375 22 factors factor NNS cord-335975-m6lkrehi 3375 23 for for IN cord-335975-m6lkrehi 3375 24 developing develop VBG cord-335975-m6lkrehi 3375 25 arrhythmia arrhythmia NN cord-335975-m6lkrehi 3375 26 during during IN cord-335975-m6lkrehi 3375 27 their -PRON- PRP$ cord-335975-m6lkrehi 3375 28 ICU ICU NNP cord-335975-m6lkrehi 3375 29 stay stay NN cord-335975-m6lkrehi 3375 30 . . . cord-335975-m6lkrehi 3376 1 The the DT cord-335975-m6lkrehi 3376 2 PROCAT PROCAT NNP cord-335975-m6lkrehi 3376 3 registry registry NN cord-335975-m6lkrehi 3376 4 captures capture VBZ cord-335975-m6lkrehi 3376 5 all all DT cord-335975-m6lkrehi 3376 6 data datum NNS cord-335975-m6lkrehi 3376 7 from from IN cord-335975-m6lkrehi 3376 8 patients patient NNS cord-335975-m6lkrehi 3376 9 admitted admit VBN cord-335975-m6lkrehi 3376 10 in in IN cord-335975-m6lkrehi 3376 11 a a DT cord-335975-m6lkrehi 3376 12 tertiary tertiary JJ cord-335975-m6lkrehi 3376 13 hospital hospital NN cord-335975-m6lkrehi 3376 14 center center NN cord-335975-m6lkrehi 3376 15 after after IN cord-335975-m6lkrehi 3376 16 a a DT cord-335975-m6lkrehi 3376 17 resuscitated resuscitate VBN cord-335975-m6lkrehi 3376 18 cardiac cardiac JJ cord-335975-m6lkrehi 3376 19 arrest arrest NN cord-335975-m6lkrehi 3376 20 ( ( -LRB- cord-335975-m6lkrehi 3376 21 CA CA NNP cord-335975-m6lkrehi 3376 22 ) ) -RRB- cord-335975-m6lkrehi 3376 23 . . . cord-335975-m6lkrehi 3377 1 We -PRON- PRP cord-335975-m6lkrehi 3377 2 selected select VBD cord-335975-m6lkrehi 3377 3 patients patient NNS cord-335975-m6lkrehi 3377 4 with with IN cord-335975-m6lkrehi 3377 5 an an DT cord-335975-m6lkrehi 3377 6 initial initial JJ cord-335975-m6lkrehi 3377 7 VF vf NN cord-335975-m6lkrehi 3377 8 VT VT NNP cord-335975-m6lkrehi 3377 9 caused cause VBN cord-335975-m6lkrehi 3377 10 by by IN cord-335975-m6lkrehi 3377 11 an an DT cord-335975-m6lkrehi 3377 12 acute acute JJ cord-335975-m6lkrehi 3377 13 coronary coronary JJ cord-335975-m6lkrehi 3377 14 syndrome syndrome NN cord-335975-m6lkrehi 3377 15 ( ( -LRB- cord-335975-m6lkrehi 3377 16 ACS ACS NNP cord-335975-m6lkrehi 3377 17 ) ) -RRB- cord-335975-m6lkrehi 3377 18 and and CC cord-335975-m6lkrehi 3377 19 who who WP cord-335975-m6lkrehi 3377 20 were be VBD cord-335975-m6lkrehi 3377 21 successfully successfully RB cord-335975-m6lkrehi 3377 22 treated treat VBN cord-335975-m6lkrehi 3377 23 with with IN cord-335975-m6lkrehi 3377 24 early early JJ cord-335975-m6lkrehi 3377 25 percutaneous percutaneous JJ cord-335975-m6lkrehi 3377 26 coronary coronary NN cord-335975-m6lkrehi 3377 27 intervention intervention NN cord-335975-m6lkrehi 3377 28 ( ( -LRB- cord-335975-m6lkrehi 3377 29 PCI PCI NNP cord-335975-m6lkrehi 3377 30 ) ) -RRB- cord-335975-m6lkrehi 3377 31 on on IN cord-335975-m6lkrehi 3377 32 admission admission NN cord-335975-m6lkrehi 3377 33 . . . cord-335975-m6lkrehi 3378 1 The the DT cord-335975-m6lkrehi 3378 2 primary primary JJ cord-335975-m6lkrehi 3378 3 endpoint endpoint NN cord-335975-m6lkrehi 3378 4 was be VBD cord-335975-m6lkrehi 3378 5 the the DT cord-335975-m6lkrehi 3378 6 recurrence recurrence NN cord-335975-m6lkrehi 3378 7 of of IN cord-335975-m6lkrehi 3378 8 major major JJ cord-335975-m6lkrehi 3378 9 arrhythmia arrhythmia NN cord-335975-m6lkrehi 3378 10 between between IN cord-335975-m6lkrehi 3378 11 ICU ICU NNP cord-335975-m6lkrehi 3378 12 admission admission NN cord-335975-m6lkrehi 3378 13 and and CC cord-335975-m6lkrehi 3378 14 ICU ICU NNP cord-335975-m6lkrehi 3378 15 discharge discharge NN cord-335975-m6lkrehi 3378 16 . . . cord-335975-m6lkrehi 3379 1 All all DT cord-335975-m6lkrehi 3379 2 arrhythmias arrhythmias RB cord-335975-m6lkrehi 3379 3 resulting result VBG cord-335975-m6lkrehi 3379 4 in in IN cord-335975-m6lkrehi 3379 5 CA CA NNP cord-335975-m6lkrehi 3379 6 recurrence recurrence NN cord-335975-m6lkrehi 3379 7 and and CC cord-335975-m6lkrehi 3379 8 or or CC cord-335975-m6lkrehi 3379 9 severe severe JJ cord-335975-m6lkrehi 3379 10 arterial arterial JJ cord-335975-m6lkrehi 3379 11 hypotension hypotension NN cord-335975-m6lkrehi 3379 12 requiring require VBG cord-335975-m6lkrehi 3379 13 infusion infusion NN cord-335975-m6lkrehi 3379 14 of of IN cord-335975-m6lkrehi 3379 15 vasopressors vasopressor NNS cord-335975-m6lkrehi 3379 16 were be VBD cord-335975-m6lkrehi 3379 17 classified classify VBN cord-335975-m6lkrehi 3379 18 as as IN cord-335975-m6lkrehi 3379 19 major major JJ cord-335975-m6lkrehi 3379 20 arrhythmias arrhythmia NNS cord-335975-m6lkrehi 3379 21 . . . cord-335975-m6lkrehi 3380 1 Multivariate multivariate JJ cord-335975-m6lkrehi 3380 2 logistic logistic JJ cord-335975-m6lkrehi 3380 3 regression regression NN cord-335975-m6lkrehi 3380 4 identified identify VBN cord-335975-m6lkrehi 3380 5 factors factor NNS cord-335975-m6lkrehi 3380 6 associated associate VBN cord-335975-m6lkrehi 3380 7 with with IN cord-335975-m6lkrehi 3380 8 the the DT cord-335975-m6lkrehi 3380 9 occurrence occurrence NN cord-335975-m6lkrehi 3380 10 of of IN cord-335975-m6lkrehi 3380 11 major major JJ cord-335975-m6lkrehi 3380 12 arrhythmias arrhythmia NNS cord-335975-m6lkrehi 3380 13 . . . cord-335975-m6lkrehi 3381 1 Results result NNS cord-335975-m6lkrehi 3381 2 : : : cord-335975-m6lkrehi 3382 1 Between between IN cord-335975-m6lkrehi 3382 2 01/2007 01/2007 CD cord-335975-m6lkrehi 3382 3 and and CC cord-335975-m6lkrehi 3382 4 12/2016 12/2016 CD cord-335975-m6lkrehi 3382 5 , , , cord-335975-m6lkrehi 3382 6 256 256 CD cord-335975-m6lkrehi 3382 7 consecutive consecutive JJ cord-335975-m6lkrehi 3382 8 CA CA NNP cord-335975-m6lkrehi 3382 9 patients patient NNS cord-335975-m6lkrehi 3382 10 were be VBD cord-335975-m6lkrehi 3382 11 included include VBN cord-335975-m6lkrehi 3382 12 in in IN cord-335975-m6lkrehi 3382 13 the the DT cord-335975-m6lkrehi 3382 14 analysis analysis NN cord-335975-m6lkrehi 3382 15 . . . cord-335975-m6lkrehi 3383 1 All all DT cord-335975-m6lkrehi 3383 2 patients patient NNS cord-335975-m6lkrehi 3383 3 underwent undergo VBD cord-335975-m6lkrehi 3383 4 a a DT cord-335975-m6lkrehi 3383 5 successful successful JJ cord-335975-m6lkrehi 3383 6 PCI pci NN cord-335975-m6lkrehi 3383 7 of of IN cord-335975-m6lkrehi 3383 8 the the DT cord-335975-m6lkrehi 3383 9 infarct infarct NN cord-335975-m6lkrehi 3383 10 - - HYPH cord-335975-m6lkrehi 3383 11 related relate VBN cord-335975-m6lkrehi 3383 12 artery artery NN cord-335975-m6lkrehi 3383 13 on on IN cord-335975-m6lkrehi 3383 14 hospital hospital NN cord-335975-m6lkrehi 3383 15 arrival arrival NN cord-335975-m6lkrehi 3383 16 . . . cord-335975-m6lkrehi 3384 1 The the DT cord-335975-m6lkrehi 3384 2 only only JJ cord-335975-m6lkrehi 3384 3 drug drug NN cord-335975-m6lkrehi 3384 4 used use VBN cord-335975-m6lkrehi 3384 5 as as IN cord-335975-m6lkrehi 3384 6 a a DT cord-335975-m6lkrehi 3384 7 prophylactic prophylactic JJ cord-335975-m6lkrehi 3384 8 AA AA NNP cord-335975-m6lkrehi 3384 9 treatment treatment NN cord-335975-m6lkrehi 3384 10 was be VBD cord-335975-m6lkrehi 3384 11 amiodarone amiodarone NN cord-335975-m6lkrehi 3384 12 , , , cord-335975-m6lkrehi 3384 13 which which WDT cord-335975-m6lkrehi 3384 14 was be VBD cord-335975-m6lkrehi 3384 15 employed employ VBN cord-335975-m6lkrehi 3384 16 in in IN cord-335975-m6lkrehi 3384 17 104/256 104/256 CD cord-335975-m6lkrehi 3384 18 patients patient NNS cord-335975-m6lkrehi 3384 19 ( ( -LRB- cord-335975-m6lkrehi 3384 20 41 41 CD cord-335975-m6lkrehi 3384 21 % % NN cord-335975-m6lkrehi 3384 22 ) ) -RRB- cord-335975-m6lkrehi 3384 23 . . . cord-335975-m6lkrehi 3385 1 Overall overall RB cord-335975-m6lkrehi 3385 2 , , , cord-335975-m6lkrehi 3385 3 29/256 29/256 CD cord-335975-m6lkrehi 3385 4 patients patient NNS cord-335975-m6lkrehi 3385 5 ( ( -LRB- cord-335975-m6lkrehi 3385 6 11.3 11.3 CD cord-335975-m6lkrehi 3385 7 % % NN cord-335975-m6lkrehi 3385 8 ) ) -RRB- cord-335975-m6lkrehi 3385 9 had have VBD cord-335975-m6lkrehi 3385 10 a a DT cord-335975-m6lkrehi 3385 11 major major JJ cord-335975-m6lkrehi 3385 12 arrhythmia arrhythmia NN cord-335975-m6lkrehi 3385 13 recurrence recurrence NN cord-335975-m6lkrehi 3385 14 during during IN cord-335975-m6lkrehi 3385 15 their -PRON- PRP$ cord-335975-m6lkrehi 3385 16 ICU ICU NNP cord-335975-m6lkrehi 3385 17 stay stay NN cord-335975-m6lkrehi 3385 18 . . . cord-335975-m6lkrehi 3386 1 A a DT cord-335975-m6lkrehi 3386 2 large large JJ cord-335975-m6lkrehi 3386 3 majority majority NN cord-335975-m6lkrehi 3386 4 of of IN cord-335975-m6lkrehi 3386 5 these these DT cord-335975-m6lkrehi 3386 6 major major JJ cord-335975-m6lkrehi 3386 7 arrhythmia arrhythmia NN cord-335975-m6lkrehi 3386 8 recurrences recurrence NNS cord-335975-m6lkrehi 3386 9 ( ( -LRB- cord-335975-m6lkrehi 3386 10 79.3 79.3 CD cord-335975-m6lkrehi 3386 11 % % NN cord-335975-m6lkrehi 3386 12 ) ) -RRB- cord-335975-m6lkrehi 3386 13 occurred occur VBD cord-335975-m6lkrehi 3386 14 during during IN cord-335975-m6lkrehi 3386 15 the the DT cord-335975-m6lkrehi 3386 16 first first JJ cord-335975-m6lkrehi 3386 17 24 24 CD cord-335975-m6lkrehi 3386 18 h. h. NNP cord-335975-m6lkrehi 3386 19 Characteristics characteristic NNS cord-335975-m6lkrehi 3386 20 of of IN cord-335975-m6lkrehi 3386 21 patients patient NNS cord-335975-m6lkrehi 3386 22 with with IN cord-335975-m6lkrehi 3386 23 and and CC cord-335975-m6lkrehi 3386 24 without without IN cord-335975-m6lkrehi 3386 25 major major JJ cord-335975-m6lkrehi 3386 26 arrhythmia arrhythmia NN cord-335975-m6lkrehi 3386 27 recurrence recurrence NN cord-335975-m6lkrehi 3386 28 are be VBP cord-335975-m6lkrehi 3386 29 described describe VBN cord-335975-m6lkrehi 3386 30 in in IN cord-335975-m6lkrehi 3386 31 the the DT cord-335975-m6lkrehi 3386 32 Table Table NNP cord-335975-m6lkrehi 3386 33 1 1 CD cord-335975-m6lkrehi 3386 34 . . . cord-335975-m6lkrehi 3387 1 In in IN cord-335975-m6lkrehi 3387 2 multivariate multivariate JJ cord-335975-m6lkrehi 3387 3 analysis analysis NN cord-335975-m6lkrehi 3387 4 , , , cord-335975-m6lkrehi 3387 5 public public JJ cord-335975-m6lkrehi 3387 6 place place NN cord-335975-m6lkrehi 3387 7 location location NN cord-335975-m6lkrehi 3387 8 ( ( -LRB- cord-335975-m6lkrehi 3387 9 OR or CC cord-335975-m6lkrehi 3387 10 0.3 0.3 CD cord-335975-m6lkrehi 3387 11 [ [ -LRB- cord-335975-m6lkrehi 3387 12 0.1 0.1 CD cord-335975-m6lkrehi 3387 13 - - SYM cord-335975-m6lkrehi 3387 14 0.9 0.9 CD cord-335975-m6lkrehi 3387 15 ] ] -RRB- cord-335975-m6lkrehi 3387 16 , , , cord-335975-m6lkrehi 3387 17 p p NN cord-335975-m6lkrehi 3387 18 = = SYM cord-335975-m6lkrehi 3387 19 0.029 0.029 CD cord-335975-m6lkrehi 3387 20 ) ) -RRB- cord-335975-m6lkrehi 3387 21 and and CC cord-335975-m6lkrehi 3387 22 male male JJ cord-335975-m6lkrehi 3387 23 gender gender NN cord-335975-m6lkrehi 3387 24 ( ( -LRB- cord-335975-m6lkrehi 3387 25 OR or CC cord-335975-m6lkrehi 3387 26 0.3 0.3 CD cord-335975-m6lkrehi 3387 27 [ [ -LRB- cord-335975-m6lkrehi 3387 28 0.1 0.1 CD cord-335975-m6lkrehi 3387 29 - - SYM cord-335975-m6lkrehi 3387 30 0.9 0.9 CD cord-335975-m6lkrehi 3387 31 ] ] -RRB- cord-335975-m6lkrehi 3387 32 , , , cord-335975-m6lkrehi 3387 33 p p NN cord-335975-m6lkrehi 3387 34 = = SYM cord-335975-m6lkrehi 3387 35 0.036 0.036 CD cord-335975-m6lkrehi 3387 36 ) ) -RRB- cord-335975-m6lkrehi 3388 1 were be VBD cord-335975-m6lkrehi 3388 2 both both DT cord-335975-m6lkrehi 3388 3 associated associate VBN cord-335975-m6lkrehi 3388 4 with with IN cord-335975-m6lkrehi 3388 5 a a DT cord-335975-m6lkrehi 3388 6 lower low JJR cord-335975-m6lkrehi 3388 7 risk risk NN cord-335975-m6lkrehi 3388 8 of of IN cord-335975-m6lkrehi 3388 9 major major JJ cord-335975-m6lkrehi 3388 10 arrhythmia arrhythmia NN cord-335975-m6lkrehi 3388 11 recurrence recurrence NN cord-335975-m6lkrehi 3388 12 during during IN cord-335975-m6lkrehi 3388 13 the the DT cord-335975-m6lkrehi 3388 14 ICU ICU NNP cord-335975-m6lkrehi 3388 15 stay stay NN cord-335975-m6lkrehi 3388 16 . . . cord-335975-m6lkrehi 3389 1 Prophylactic prophylactic JJ cord-335975-m6lkrehi 3389 2 AA AA NNP cord-335975-m6lkrehi 3389 3 treatment treatment NN cord-335975-m6lkrehi 3389 4 was be VBD cord-335975-m6lkrehi 3389 5 not not RB cord-335975-m6lkrehi 3389 6 associated associate VBN cord-335975-m6lkrehi 3389 7 with with IN cord-335975-m6lkrehi 3389 8 a a DT cord-335975-m6lkrehi 3389 9 lower low JJR cord-335975-m6lkrehi 3389 10 risk risk NN cord-335975-m6lkrehi 3389 11 of of IN cord-335975-m6lkrehi 3389 12 recurrences recurrence NNS cord-335975-m6lkrehi 3389 13 of of IN cord-335975-m6lkrehi 3389 14 major major JJ cord-335975-m6lkrehi 3389 15 arrhythmias arrhythmia NNS cord-335975-m6lkrehi 3389 16 ( ( -LRB- cord-335975-m6lkrehi 3389 17 OR or CC cord-335975-m6lkrehi 3389 18 0.9 0.9 CD cord-335975-m6lkrehi 3389 19 [ [ -LRB- cord-335975-m6lkrehi 3389 20 0.3 0.3 CD cord-335975-m6lkrehi 3389 21 - - SYM cord-335975-m6lkrehi 3389 22 3.1 3.1 CD cord-335975-m6lkrehi 3389 23 ] ] -RRB- cord-335975-m6lkrehi 3389 24 , , , cord-335975-m6lkrehi 3389 25 p p NN cord-335975-m6lkrehi 3389 26 = = SYM cord-335975-m6lkrehi 3389 27 0.870 0.870 CD cord-335975-m6lkrehi 3389 28 ) ) -RRB- cord-335975-m6lkrehi 3389 29 . . . cord-335975-m6lkrehi 3390 1 Conclusion conclusion NN cord-335975-m6lkrehi 3390 2 : : : cord-335975-m6lkrehi 3391 1 Despite despite IN cord-335975-m6lkrehi 3391 2 an an DT cord-335975-m6lkrehi 3391 3 early early JJ cord-335975-m6lkrehi 3391 4 coronary coronary JJ cord-335975-m6lkrehi 3391 5 reperfusion reperfusion NN cord-335975-m6lkrehi 3391 6 , , , cord-335975-m6lkrehi 3391 7 more more JJR cord-335975-m6lkrehi 3391 8 than than IN cord-335975-m6lkrehi 3391 9 10 10 CD cord-335975-m6lkrehi 3391 10 % % NN cord-335975-m6lkrehi 3391 11 of of IN cord-335975-m6lkrehi 3391 12 our -PRON- PRP$ cord-335975-m6lkrehi 3391 13 post post JJ cord-335975-m6lkrehi 3391 14 - - JJ cord-335975-m6lkrehi 3391 15 cardiac cardiac JJ cord-335975-m6lkrehi 3391 16 arrest arrest NN cord-335975-m6lkrehi 3391 17 patients patient NNS cord-335975-m6lkrehi 3391 18 experienced experience VBD cord-335975-m6lkrehi 3391 19 a a DT cord-335975-m6lkrehi 3391 20 recurrent recurrent JJ cord-335975-m6lkrehi 3391 21 severe severe JJ cord-335975-m6lkrehi 3391 22 arrhythmia arrhythmia NN cord-335975-m6lkrehi 3391 23 during during IN cord-335975-m6lkrehi 3391 24 the the DT cord-335975-m6lkrehi 3391 25 post post JJ cord-335975-m6lkrehi 3391 26 - - JJ cord-335975-m6lkrehi 3391 27 resuscitation resuscitation JJ cord-335975-m6lkrehi 3391 28 period period NN cord-335975-m6lkrehi 3391 29 , , , cord-335975-m6lkrehi 3391 30 mostly mostly RB cord-335975-m6lkrehi 3391 31 during during IN cord-335975-m6lkrehi 3391 32 the the DT cord-335975-m6lkrehi 3391 33 first first JJ cord-335975-m6lkrehi 3391 34 24 24 CD cord-335975-m6lkrehi 3391 35 h h NN cord-335975-m6lkrehi 3391 36 in in IN cord-335975-m6lkrehi 3391 37 the the DT cord-335975-m6lkrehi 3391 38 ICU ICU NNP cord-335975-m6lkrehi 3391 39 . . . cord-335975-m6lkrehi 3392 1 This this DT cord-335975-m6lkrehi 3392 2 proportion proportion NN cord-335975-m6lkrehi 3392 3 is be VBZ cord-335975-m6lkrehi 3392 4 much much RB cord-335975-m6lkrehi 3392 5 higher high JJR cord-335975-m6lkrehi 3392 6 than than IN cord-335975-m6lkrehi 3392 7 what what WP cord-335975-m6lkrehi 3392 8 is be VBZ cord-335975-m6lkrehi 3392 9 reported report VBN cord-335975-m6lkrehi 3392 10 in in IN cord-335975-m6lkrehi 3392 11 common common JJ cord-335975-m6lkrehi 3392 12 acute acute JJ cord-335975-m6lkrehi 3392 13 coronary coronary JJ cord-335975-m6lkrehi 3392 14 syndrome syndrome NN cord-335975-m6lkrehi 3392 15 ( ( -LRB- cord-335975-m6lkrehi 3392 16 without without IN cord-335975-m6lkrehi 3392 17 cardiac cardiac JJ cord-335975-m6lkrehi 3392 18 arrest arrest NN cord-335975-m6lkrehi 3392 19 ) ) -RRB- cord-335975-m6lkrehi 3392 20 and and CC cord-335975-m6lkrehi 3392 21 further further JJ cord-335975-m6lkrehi 3392 22 studies study NNS cord-335975-m6lkrehi 3392 23 are be VBP cord-335975-m6lkrehi 3392 24 needed need VBN cord-335975-m6lkrehi 3392 25 to to TO cord-335975-m6lkrehi 3392 26 explore explore VB cord-335975-m6lkrehi 3392 27 protective protective JJ cord-335975-m6lkrehi 3392 28 strategies strategy NNS cord-335975-m6lkrehi 3392 29 . . . cord-335975-m6lkrehi 3393 1 Introduction introduction NN cord-335975-m6lkrehi 3393 2 : : : cord-335975-m6lkrehi 3394 1 During during IN cord-335975-m6lkrehi 3394 2 symptomatic symptomatic JJ cord-335975-m6lkrehi 3394 3 treatment treatment NN cord-335975-m6lkrehi 3394 4 of of IN cord-335975-m6lkrehi 3394 5 septic septic JJ cord-335975-m6lkrehi 3394 6 shock shock NN cord-335975-m6lkrehi 3394 7 , , , cord-335975-m6lkrehi 3394 8 markers marker NNS cord-335975-m6lkrehi 3394 9 of of IN cord-335975-m6lkrehi 3394 10 anaerobic anaerobic JJ cord-335975-m6lkrehi 3394 11 metabolism metabolism NN cord-335975-m6lkrehi 3394 12 may may MD cord-335975-m6lkrehi 3394 13 be be VB cord-335975-m6lkrehi 3394 14 used use VBN cord-335975-m6lkrehi 3394 15 in in IN cord-335975-m6lkrehi 3394 16 a a DT cord-335975-m6lkrehi 3394 17 goal goal NN cord-335975-m6lkrehi 3394 18 - - HYPH cord-335975-m6lkrehi 3394 19 oriented orient VBN cord-335975-m6lkrehi 3394 20 strategy strategy NN cord-335975-m6lkrehi 3394 21 . . . cord-335975-m6lkrehi 3395 1 The the DT cord-335975-m6lkrehi 3395 2 recent recent JJ cord-335975-m6lkrehi 3395 3 International International NNP cord-335975-m6lkrehi 3395 4 Guidelines Guidelines NNPS cord-335975-m6lkrehi 3395 5 for for IN cord-335975-m6lkrehi 3395 6 Management Management NNP cord-335975-m6lkrehi 3395 7 of of IN cord-335975-m6lkrehi 3395 8 Sepsis Sepsis NNP cord-335975-m6lkrehi 3395 9 and and CC cord-335975-m6lkrehi 3395 10 Septic Septic NNP cord-335975-m6lkrehi 3395 11 Shock Shock NNP cord-335975-m6lkrehi 3395 12 2016 2016 CD cord-335975-m6lkrehi 3395 13 suggested suggest VBD cord-335975-m6lkrehi 3395 14 guiding guide VBG cord-335975-m6lkrehi 3395 15 resuscitation resuscitation NN cord-335975-m6lkrehi 3395 16 to to TO cord-335975-m6lkrehi 3395 17 normalize normalize VB cord-335975-m6lkrehi 3395 18 lactate lactate NN cord-335975-m6lkrehi 3395 19 as as IN cord-335975-m6lkrehi 3395 20 a a DT cord-335975-m6lkrehi 3395 21 marker marker NN cord-335975-m6lkrehi 3395 22 of of IN cord-335975-m6lkrehi 3395 23 tissue tissue NN cord-335975-m6lkrehi 3395 24 hypoperfusion hypoperfusion NN cord-335975-m6lkrehi 3395 25 . . . cord-335975-m6lkrehi 3396 1 The the DT cord-335975-m6lkrehi 3396 2 purpose purpose NN cord-335975-m6lkrehi 3396 3 of of IN cord-335975-m6lkrehi 3396 4 this this DT cord-335975-m6lkrehi 3396 5 study study NN cord-335975-m6lkrehi 3396 6 was be VBD cord-335975-m6lkrehi 3396 7 to to TO cord-335975-m6lkrehi 3396 8 evaluate evaluate VB cord-335975-m6lkrehi 3396 9 the the DT cord-335975-m6lkrehi 3396 10 kinetics kinetic NNS cord-335975-m6lkrehi 3396 11 of of IN cord-335975-m6lkrehi 3396 12 lactate lactate NN cord-335975-m6lkrehi 3396 13 and and CC cord-335975-m6lkrehi 3396 14 other other JJ cord-335975-m6lkrehi 3396 15 markers marker NNS cord-335975-m6lkrehi 3396 16 during during IN cord-335975-m6lkrehi 3396 17 the the DT cord-335975-m6lkrehi 3396 18 first first JJ cord-335975-m6lkrehi 3396 19 three three CD cord-335975-m6lkrehi 3396 20 hours hour NNS cord-335975-m6lkrehi 3396 21 and and CC cord-335975-m6lkrehi 3396 22 to to TO cord-335975-m6lkrehi 3396 23 compare compare VB cord-335975-m6lkrehi 3396 24 their -PRON- PRP$ cord-335975-m6lkrehi 3396 25 levels level NNS cord-335975-m6lkrehi 3396 26 between between IN cord-335975-m6lkrehi 3396 27 survivors survivor NNS cord-335975-m6lkrehi 3396 28 and and CC cord-335975-m6lkrehi 3396 29 non non JJ cord-335975-m6lkrehi 3396 30 survivors survivor NNS cord-335975-m6lkrehi 3396 31 . . . cord-335975-m6lkrehi 3397 1 We -PRON- PRP cord-335975-m6lkrehi 3397 2 conducted conduct VBD cord-335975-m6lkrehi 3397 3 a a DT cord-335975-m6lkrehi 3397 4 prospective prospective JJ cord-335975-m6lkrehi 3397 5 , , , cord-335975-m6lkrehi 3397 6 observational observational JJ cord-335975-m6lkrehi 3397 7 , , , cord-335975-m6lkrehi 3397 8 single single JJ cord-335975-m6lkrehi 3397 9 - - HYPH cord-335975-m6lkrehi 3397 10 center center NN cord-335975-m6lkrehi 3397 11 study study NN cord-335975-m6lkrehi 3397 12 of of IN cord-335975-m6lkrehi 3397 13 patients patient NNS cord-335975-m6lkrehi 3397 14 admitted admit VBN cord-335975-m6lkrehi 3397 15 to to IN cord-335975-m6lkrehi 3397 16 a a DT cord-335975-m6lkrehi 3397 17 general general JJ cord-335975-m6lkrehi 3397 18 ICU ICU NNP cord-335975-m6lkrehi 3397 19 from from IN cord-335975-m6lkrehi 3397 20 the the DT cord-335975-m6lkrehi 3397 21 May May NNP cord-335975-m6lkrehi 3397 22 to to IN cord-335975-m6lkrehi 3397 23 August August NNP cord-335975-m6lkrehi 3397 24 2016 2016 CD cord-335975-m6lkrehi 3397 25 . . . cord-335975-m6lkrehi 3398 1 Inclusion inclusion NN cord-335975-m6lkrehi 3398 2 criteria criterion NNS cord-335975-m6lkrehi 3398 3 were be VBD cord-335975-m6lkrehi 3398 4 patients patient NNS cord-335975-m6lkrehi 3398 5 age age NN cord-335975-m6lkrehi 3398 6 ≥ ≥ CD cord-335975-m6lkrehi 3398 7 18 18 CD cord-335975-m6lkrehi 3398 8 , , , cord-335975-m6lkrehi 3398 9 intubated intubate VBN cord-335975-m6lkrehi 3398 10 and and CC cord-335975-m6lkrehi 3398 11 under under IN cord-335975-m6lkrehi 3398 12 mechanical mechanical JJ cord-335975-m6lkrehi 3398 13 ventilation ventilation NN cord-335975-m6lkrehi 3398 14 with with IN cord-335975-m6lkrehi 3398 15 septic septic JJ cord-335975-m6lkrehi 3398 16 shock shock NN cord-335975-m6lkrehi 3398 17 as as IN cord-335975-m6lkrehi 3398 18 defined define VBN cord-335975-m6lkrehi 3398 19 by by IN cord-335975-m6lkrehi 3398 20 the the DT cord-335975-m6lkrehi 3398 21 Third Third NNP cord-335975-m6lkrehi 3398 22 International International NNP cord-335975-m6lkrehi 3398 23 Consensus Consensus NNP cord-335975-m6lkrehi 3398 24 Conference Conference NNP cord-335975-m6lkrehi 3398 25 . . . cord-335975-m6lkrehi 3399 1 Simultaneous simultaneous JJ cord-335975-m6lkrehi 3399 2 sampling sampling NN cord-335975-m6lkrehi 3399 3 of of IN cord-335975-m6lkrehi 3399 4 arterial arterial JJ cord-335975-m6lkrehi 3399 5 and and CC cord-335975-m6lkrehi 3399 6 central central JJ cord-335975-m6lkrehi 3399 7 venous venous JJ cord-335975-m6lkrehi 3399 8 blood blood NN cord-335975-m6lkrehi 3399 9 gas gas NN cord-335975-m6lkrehi 3399 10 were be VBD cord-335975-m6lkrehi 3399 11 collected collect VBN cord-335975-m6lkrehi 3399 12 at at IN cord-335975-m6lkrehi 3399 13 H0 H0 NNP cord-335975-m6lkrehi 3399 14 and and CC cord-335975-m6lkrehi 3399 15 H3 H3 NNP cord-335975-m6lkrehi 3399 16 to to TO cord-335975-m6lkrehi 3399 17 obtain obtain VB cord-335975-m6lkrehi 3399 18 lactate lactate NN cord-335975-m6lkrehi 3399 19 ( ( -LRB- cord-335975-m6lkrehi 3399 20 mmol mmol NNP cord-335975-m6lkrehi 3399 21 / / SYM cord-335975-m6lkrehi 3399 22 l l NN cord-335975-m6lkrehi 3399 23 ) ) -RRB- cord-335975-m6lkrehi 3399 24 , , , cord-335975-m6lkrehi 3399 25 and and CC cord-335975-m6lkrehi 3399 26 ScvO2 ScvO2 NNP cord-335975-m6lkrehi 3399 27 ( ( -LRB- cord-335975-m6lkrehi 3399 28 % % NN cord-335975-m6lkrehi 3399 29 ) ) -RRB- cord-335975-m6lkrehi 3399 30 . . . cord-335975-m6lkrehi 3400 1 Delta Delta NNP cord-335975-m6lkrehi 3400 2 PCO2 PCO2 NNP cord-335975-m6lkrehi 3400 3 ( ( -LRB- cord-335975-m6lkrehi 3400 4 mmHg mmHg NNP cord-335975-m6lkrehi 3400 5 ) ) -RRB- cord-335975-m6lkrehi 3400 6 and and CC cord-335975-m6lkrehi 3401 1 delta delta NNP cord-335975-m6lkrehi 3401 2 PCO2 PCO2 NNP cord-335975-m6lkrehi 3401 3 / / SYM cord-335975-m6lkrehi 3401 4 CavO2 CavO2 NNP cord-335975-m6lkrehi 3401 5 ( ( -LRB- cord-335975-m6lkrehi 3401 6 mmHg mmHg NNP cord-335975-m6lkrehi 3401 7 / / SYM cord-335975-m6lkrehi 3401 8 ml ml NN cord-335975-m6lkrehi 3401 9 ) ) -RRB- cord-335975-m6lkrehi 3401 10 were be VBD cord-335975-m6lkrehi 3401 11 computed compute VBN cord-335975-m6lkrehi 3401 12 by by IN cord-335975-m6lkrehi 3401 13 our -PRON- PRP$ cord-335975-m6lkrehi 3401 14 Patient Patient NNP cord-335975-m6lkrehi 3401 15 Data Data NNP cord-335975-m6lkrehi 3401 16 Management Management NNP cord-335975-m6lkrehi 3401 17 System System NNP cord-335975-m6lkrehi 3401 18 and and CC cord-335975-m6lkrehi 3401 19 presented present VBD cord-335975-m6lkrehi 3401 20 as as IN cord-335975-m6lkrehi 3401 21 a a DT cord-335975-m6lkrehi 3401 22 chart chart NN cord-335975-m6lkrehi 3401 23 with with IN cord-335975-m6lkrehi 3401 24 additional additional JJ cord-335975-m6lkrehi 3401 25 hemodynamic hemodynamic JJ cord-335975-m6lkrehi 3401 26 data datum NNS cord-335975-m6lkrehi 3401 27 for for IN cord-335975-m6lkrehi 3401 28 clinical clinical JJ cord-335975-m6lkrehi 3401 29 decision decision NN cord-335975-m6lkrehi 3401 30 support support NN cord-335975-m6lkrehi 3401 31 . . . cord-335975-m6lkrehi 3402 1 Comparisons comparison NNS cord-335975-m6lkrehi 3402 2 of of IN cord-335975-m6lkrehi 3402 3 values value NNS cord-335975-m6lkrehi 3402 4 between between IN cord-335975-m6lkrehi 3402 5 groups group NNS cord-335975-m6lkrehi 3402 6 were be VBD cord-335975-m6lkrehi 3402 7 made make VBN cord-335975-m6lkrehi 3402 8 by by IN cord-335975-m6lkrehi 3402 9 Mann Mann NNP cord-335975-m6lkrehi 3402 10 - - HYPH cord-335975-m6lkrehi 3402 11 Whitney Whitney NNP cord-335975-m6lkrehi 3402 12 U U NNP cord-335975-m6lkrehi 3402 13 test test VBP cord-335975-m6lkrehi 3402 14 as as IN cord-335975-m6lkrehi 3402 15 appropriate appropriate JJ cord-335975-m6lkrehi 3402 16 . . . cord-335975-m6lkrehi 3403 1 p p NN cord-335975-m6lkrehi 3403 2 < < XX cord-335975-m6lkrehi 3403 3 0.05 0.05 CD cord-335975-m6lkrehi 3403 4 was be VBD cord-335975-m6lkrehi 3403 5 considered consider VBN cord-335975-m6lkrehi 3403 6 statistically statistically RB cord-335975-m6lkrehi 3403 7 significant significant JJ cord-335975-m6lkrehi 3403 8 . . . cord-335975-m6lkrehi 3404 1 All all DT cord-335975-m6lkrehi 3404 2 reported report VBD cord-335975-m6lkrehi 3404 3 p p NN cord-335975-m6lkrehi 3404 4 values value NNS cord-335975-m6lkrehi 3404 5 are be VBP cord-335975-m6lkrehi 3404 6 two two CD cord-335975-m6lkrehi 3404 7 - - HYPH cord-335975-m6lkrehi 3404 8 sided sided JJ cord-335975-m6lkrehi 3404 9 . . . cord-335975-m6lkrehi 3405 1 Statistical statistical JJ cord-335975-m6lkrehi 3405 2 analysis analysis NN cord-335975-m6lkrehi 3405 3 was be VBD cord-335975-m6lkrehi 3405 4 performed perform VBN cord-335975-m6lkrehi 3405 5 using use VBG cord-335975-m6lkrehi 3405 6 Systat Systat NNP cord-335975-m6lkrehi 3405 7 ver ver NN cord-335975-m6lkrehi 3405 8 . . . cord-335975-m6lkrehi 3406 1 11.0 11.0 CD cord-335975-m6lkrehi 3406 2 . . . cord-335975-m6lkrehi 3407 1 Results result NNS cord-335975-m6lkrehi 3407 2 : : : cord-335975-m6lkrehi 3408 1 We -PRON- PRP cord-335975-m6lkrehi 3408 2 studied study VBD cord-335975-m6lkrehi 3408 3 19 19 CD cord-335975-m6lkrehi 3408 4 intubated intubate VBD cord-335975-m6lkrehi 3408 5 septic septic JJ cord-335975-m6lkrehi 3408 6 shock shock NN cord-335975-m6lkrehi 3408 7 patients patient NNS cord-335975-m6lkrehi 3408 8 aged age VBD cord-335975-m6lkrehi 3408 9 71 71 CD cord-335975-m6lkrehi 3408 10 ± ± CD cord-335975-m6lkrehi 3408 11 10 10 CD cord-335975-m6lkrehi 3408 12 years year NNS cord-335975-m6lkrehi 3408 13 , , , cord-335975-m6lkrehi 3408 14 SAPS SAPS NNP cord-335975-m6lkrehi 3408 15 II II NNP cord-335975-m6lkrehi 3408 16 68 68 CD cord-335975-m6lkrehi 3408 17 ± ± CD cord-335975-m6lkrehi 3408 18 23 23 CD cord-335975-m6lkrehi 3408 19 , , , cord-335975-m6lkrehi 3408 20 SOFA sofa NN cord-335975-m6lkrehi 3408 21 11 11 CD cord-335975-m6lkrehi 3408 22 ± ± NNP cord-335975-m6lkrehi 3408 23 3.6 3.6 CD cord-335975-m6lkrehi 3408 24 . . . cord-335975-m6lkrehi 3409 1 Community community NN cord-335975-m6lkrehi 3409 2 pneumonia pneumonia NN cord-335975-m6lkrehi 3409 3 and and CC cord-335975-m6lkrehi 3409 4 peritonitis peritonitis NN cord-335975-m6lkrehi 3409 5 were be VBD cord-335975-m6lkrehi 3409 6 the the DT cord-335975-m6lkrehi 3409 7 major major JJ cord-335975-m6lkrehi 3409 8 sources source NNS cord-335975-m6lkrehi 3409 9 of of IN cord-335975-m6lkrehi 3409 10 infection infection NN cord-335975-m6lkrehi 3409 11 . . . cord-335975-m6lkrehi 3410 1 ICU ICU NNP cord-335975-m6lkrehi 3410 2 mortality mortality NN cord-335975-m6lkrehi 3410 3 rate rate NN cord-335975-m6lkrehi 3410 4 was be VBD cord-335975-m6lkrehi 3410 5 58 58 CD cord-335975-m6lkrehi 3410 6 % % NN cord-335975-m6lkrehi 3410 7 . . . cord-335975-m6lkrehi 3411 1 All all DT cord-335975-m6lkrehi 3411 2 patients patient NNS cord-335975-m6lkrehi 3411 3 received receive VBD cord-335975-m6lkrehi 3411 4 norepinephrine norepinephrine NN cord-335975-m6lkrehi 3411 5 ( ( -LRB- cord-335975-m6lkrehi 3411 6 0.62 0.62 CD cord-335975-m6lkrehi 3411 7 ± ± NNP cord-335975-m6lkrehi 3411 8 0.5 0.5 CD cord-335975-m6lkrehi 3411 9 µg µg NN cord-335975-m6lkrehi 3411 10 / / SYM cord-335975-m6lkrehi 3411 11 kg/ kg/ NNS cord-335975-m6lkrehi 3411 12 min min NNP cord-335975-m6lkrehi 3411 13 ) ) -RRB- cord-335975-m6lkrehi 3411 14 , , , cord-335975-m6lkrehi 3411 15 two two CD cord-335975-m6lkrehi 3411 16 patients patient NNS cord-335975-m6lkrehi 3411 17 received receive VBD cord-335975-m6lkrehi 3411 18 Dobutamine Dobutamine NNP cord-335975-m6lkrehi 3411 19 ( ( -LRB- cord-335975-m6lkrehi 3411 20 5.5 5.5 CD cord-335975-m6lkrehi 3411 21 ± ± NNP cord-335975-m6lkrehi 3411 22 0.2 0.2 CD cord-335975-m6lkrehi 3411 23 µg µg NN cord-335975-m6lkrehi 3411 24 / / SYM cord-335975-m6lkrehi 3411 25 kg kg NNP cord-335975-m6lkrehi 3411 26 / / SYM cord-335975-m6lkrehi 3411 27 min min NNP cord-335975-m6lkrehi 3411 28 ) ) -RRB- cord-335975-m6lkrehi 3411 29 . . . cord-335975-m6lkrehi 3412 1 The the DT cord-335975-m6lkrehi 3412 2 evolution evolution NN cord-335975-m6lkrehi 3412 3 of of IN cord-335975-m6lkrehi 3412 4 markers marker NNS cord-335975-m6lkrehi 3412 5 is be VBZ cord-335975-m6lkrehi 3412 6 summarized summarize VBN cord-335975-m6lkrehi 3412 7 in in IN cord-335975-m6lkrehi 3412 8 Table Table NNP cord-335975-m6lkrehi 3412 9 1 1 CD cord-335975-m6lkrehi 3412 10 . . . cord-335975-m6lkrehi 3413 1 At at IN cord-335975-m6lkrehi 3413 2 H0 H0 NNP cord-335975-m6lkrehi 3413 3 and and CC cord-335975-m6lkrehi 3413 4 H3 H3 NNP cord-335975-m6lkrehi 3413 5 , , , cord-335975-m6lkrehi 3413 6 arterial arterial JJ cord-335975-m6lkrehi 3413 7 lactate lactate NN cord-335975-m6lkrehi 3413 8 levels level NNS cord-335975-m6lkrehi 3413 9 were be VBD cord-335975-m6lkrehi 3413 10 higher high JJR cord-335975-m6lkrehi 3413 11 in in IN cord-335975-m6lkrehi 3413 12 non non NNS cord-335975-m6lkrehi 3413 13 - - NNS cord-335975-m6lkrehi 3413 14 survivors survivor NNS cord-335975-m6lkrehi 3413 15 than than IN cord-335975-m6lkrehi 3413 16 in in IN cord-335975-m6lkrehi 3413 17 survivors survivor NNS cord-335975-m6lkrehi 3413 18 , , , cord-335975-m6lkrehi 3413 19 but but CC cord-335975-m6lkrehi 3413 20 did do VBD cord-335975-m6lkrehi 3413 21 not not RB cord-335975-m6lkrehi 3413 22 decrease decrease VB cord-335975-m6lkrehi 3413 23 at at IN cord-335975-m6lkrehi 3413 24 H3 H3 NNP cord-335975-m6lkrehi 3413 25 in in IN cord-335975-m6lkrehi 3413 26 both both DT cord-335975-m6lkrehi 3413 27 groups group NNS cord-335975-m6lkrehi 3413 28 . . . cord-335975-m6lkrehi 3414 1 At at IN cord-335975-m6lkrehi 3414 2 H0 H0 NNP cord-335975-m6lkrehi 3414 3 there there EX cord-335975-m6lkrehi 3414 4 was be VBD cord-335975-m6lkrehi 3414 5 no no DT cord-335975-m6lkrehi 3414 6 statistical statistical JJ cord-335975-m6lkrehi 3414 7 difference difference NN cord-335975-m6lkrehi 3414 8 concerning concern VBG cord-335975-m6lkrehi 3414 9 ScvO2 ScvO2 NNP cord-335975-m6lkrehi 3414 10 , , , cord-335975-m6lkrehi 3414 11 delta delta NNP cord-335975-m6lkrehi 3414 12 PCO2 PCO2 NNP cord-335975-m6lkrehi 3414 13 and and CC cord-335975-m6lkrehi 3414 14 delta delta NNP cord-335975-m6lkrehi 3414 15 PCO2 PCO2 NNP cord-335975-m6lkrehi 3414 16 / / SYM cord-335975-m6lkrehi 3414 17 CavO2 CavO2 NNP cord-335975-m6lkrehi 3414 18 . . . cord-335975-m6lkrehi 3415 1 After after IN cord-335975-m6lkrehi 3415 2 three three CD cord-335975-m6lkrehi 3415 3 hours hour NNS cord-335975-m6lkrehi 3415 4 of of IN cord-335975-m6lkrehi 3415 5 resuscitation resuscitation NN cord-335975-m6lkrehi 3415 6 , , , cord-335975-m6lkrehi 3415 7 delta delta NNP cord-335975-m6lkrehi 3415 8 PCO2 PCO2 NNP cord-335975-m6lkrehi 3415 9 and and CC cord-335975-m6lkrehi 3415 10 delta delta NNP cord-335975-m6lkrehi 3415 11 PCO2 PCO2 NNP cord-335975-m6lkrehi 3415 12 / / SYM cord-335975-m6lkrehi 3415 13 CavO2 CavO2 NNP cord-335975-m6lkrehi 3415 14 ratio ratio NN cord-335975-m6lkrehi 3415 15 decreased decrease VBD cord-335975-m6lkrehi 3415 16 and and CC cord-335975-m6lkrehi 3415 17 ScvO2 ScvO2 NNP cord-335975-m6lkrehi 3415 18 increased increase VBD cord-335975-m6lkrehi 3415 19 in in IN cord-335975-m6lkrehi 3415 20 survivors survivor NNS cord-335975-m6lkrehi 3415 21 . . . cord-335975-m6lkrehi 3416 1 Survivors survivor NNS cord-335975-m6lkrehi 3416 2 had have VBD cord-335975-m6lkrehi 3416 3 lower low JJR cord-335975-m6lkrehi 3416 4 delta delta NN cord-335975-m6lkrehi 3416 5 PCO2 PCO2 NNP cord-335975-m6lkrehi 3416 6 and and CC cord-335975-m6lkrehi 3417 1 delta delta NNP cord-335975-m6lkrehi 3417 2 PCO2 PCO2 NNP cord-335975-m6lkrehi 3417 3 / / SYM cord-335975-m6lkrehi 3417 4 CavO2 CavO2 NNP cord-335975-m6lkrehi 3417 5 ratio ratio NN cord-335975-m6lkrehi 3417 6 than than IN cord-335975-m6lkrehi 3417 7 non non JJ cord-335975-m6lkrehi 3417 8 survivors survivor NNS cord-335975-m6lkrehi 3417 9 . . . cord-335975-m6lkrehi 3418 1 Conclusion conclusion NN cord-335975-m6lkrehi 3418 2 : : : cord-335975-m6lkrehi 3419 1 Although although IN cord-335975-m6lkrehi 3419 2 high high JJ cord-335975-m6lkrehi 3419 3 lactate lactate NN cord-335975-m6lkrehi 3419 4 level level NN cord-335975-m6lkrehi 3419 5 is be VBZ cord-335975-m6lkrehi 3419 6 a a DT cord-335975-m6lkrehi 3419 7 key key JJ cord-335975-m6lkrehi 3419 8 signal signal NN cord-335975-m6lkrehi 3419 9 of of IN cord-335975-m6lkrehi 3419 10 anaerobic anaerobic JJ cord-335975-m6lkrehi 3419 11 metabolism metabolism NN cord-335975-m6lkrehi 3419 12 , , , cord-335975-m6lkrehi 3419 13 it -PRON- PRP cord-335975-m6lkrehi 3419 14 did do VBD cord-335975-m6lkrehi 3419 15 not not RB cord-335975-m6lkrehi 3419 16 decrease decrease VB cord-335975-m6lkrehi 3419 17 during during IN cord-335975-m6lkrehi 3419 18 the the DT cord-335975-m6lkrehi 3419 19 first first JJ cord-335975-m6lkrehi 3419 20 three three CD cord-335975-m6lkrehi 3419 21 hours hour NNS cord-335975-m6lkrehi 3419 22 in in IN cord-335975-m6lkrehi 3419 23 this this DT cord-335975-m6lkrehi 3419 24 group group NN cord-335975-m6lkrehi 3419 25 of of IN cord-335975-m6lkrehi 3419 26 severe severe JJ cord-335975-m6lkrehi 3419 27 septic septic JJ cord-335975-m6lkrehi 3419 28 shock shock NN cord-335975-m6lkrehi 3419 29 patients patient NNS cord-335975-m6lkrehi 3419 30 . . . cord-335975-m6lkrehi 3420 1 Instead instead RB cord-335975-m6lkrehi 3420 2 of of IN cord-335975-m6lkrehi 3420 3 using use VBG cord-335975-m6lkrehi 3420 4 lactate lactate NN cord-335975-m6lkrehi 3420 5 , , , cord-335975-m6lkrehi 3420 6 delta delta NNP cord-335975-m6lkrehi 3420 7 PCO2 PCO2 NNP cord-335975-m6lkrehi 3420 8 and and CC cord-335975-m6lkrehi 3420 9 delta delta NNP cord-335975-m6lkrehi 3421 1 PCO2 PCO2 NNP cord-335975-m6lkrehi 3421 2 / / SYM cord-335975-m6lkrehi 3421 3 CavO2 CavO2 NNP cord-335975-m6lkrehi 3421 4 kinetics kinetic NNS cord-335975-m6lkrehi 3421 5 could could MD cord-335975-m6lkrehi 3421 6 be be VB cord-335975-m6lkrehi 3421 7 integrated integrate VBN cord-335975-m6lkrehi 3421 8 in in IN cord-335975-m6lkrehi 3421 9 a a DT cord-335975-m6lkrehi 3421 10 goaloriented goaloriented JJ cord-335975-m6lkrehi 3421 11 strategy strategy NN cord-335975-m6lkrehi 3421 12 for for IN cord-335975-m6lkrehi 3421 13 septic septic JJ cord-335975-m6lkrehi 3421 14 shock shock NN cord-335975-m6lkrehi 3421 15 resuscitation resuscitation NN cord-335975-m6lkrehi 3421 16 . . . cord-335975-m6lkrehi 3422 1 Introduction introduction NN cord-335975-m6lkrehi 3422 2 : : : cord-335975-m6lkrehi 3423 1 To to TO cord-335975-m6lkrehi 3423 2 assess assess VB cord-335975-m6lkrehi 3423 3 whether whether IN cord-335975-m6lkrehi 3423 4 , , , cord-335975-m6lkrehi 3423 5 in in IN cord-335975-m6lkrehi 3423 6 patients patient NNS cord-335975-m6lkrehi 3423 7 under under IN cord-335975-m6lkrehi 3423 8 mechanical mechanical JJ cord-335975-m6lkrehi 3423 9 ventilation ventilation NN cord-335975-m6lkrehi 3423 10 , , , cord-335975-m6lkrehi 3423 11 fluid fluid JJ cord-335975-m6lkrehi 3423 12 responsiveness responsiveness NN cord-335975-m6lkrehi 3423 13 is be VBZ cord-335975-m6lkrehi 3423 14 predicted predict VBN cord-335975-m6lkrehi 3423 15 by by IN cord-335975-m6lkrehi 3423 16 the the DT cord-335975-m6lkrehi 3423 17 effects effect NNS cord-335975-m6lkrehi 3423 18 of of IN cord-335975-m6lkrehi 3423 19 short short JJ cord-335975-m6lkrehi 3423 20 respiratory respiratory NN cord-335975-m6lkrehi 3423 21 holds hold VBZ cord-335975-m6lkrehi 3423 22 on on IN cord-335975-m6lkrehi 3423 23 cardiac cardiac JJ cord-335975-m6lkrehi 3423 24 index index NN cord-335975-m6lkrehi 3423 25 estimated estimate VBN cord-335975-m6lkrehi 3423 26 by by IN cord-335975-m6lkrehi 3423 27 oesophageal oesophageal JJ cord-335975-m6lkrehi 3423 28 Doppler Doppler NNP cord-335975-m6lkrehi 3423 29 ( ( -LRB- cord-335975-m6lkrehi 3423 30 CIDoppler CIDoppler NNP cord-335975-m6lkrehi 3423 31 ) ) -RRB- cord-335975-m6lkrehi 3423 32 . . . cord-335975-m6lkrehi 3424 1 Patients patient NNS cord-335975-m6lkrehi 3424 2 and and CC cord-335975-m6lkrehi 3424 3 methods method NNS cord-335975-m6lkrehi 3424 4 : : : cord-335975-m6lkrehi 3424 5 In in IN cord-335975-m6lkrehi 3424 6 28 28 CD cord-335975-m6lkrehi 3424 7 patients patient NNS cord-335975-m6lkrehi 3424 8 , , , cord-335975-m6lkrehi 3424 9 before before IN cord-335975-m6lkrehi 3424 10 infusing infuse VBG cord-335975-m6lkrehi 3424 11 500 500 CD cord-335975-m6lkrehi 3424 12 mL ml NN cord-335975-m6lkrehi 3424 13 of of IN cord-335975-m6lkrehi 3424 14 saline saline NN cord-335975-m6lkrehi 3424 15 , , , cord-335975-m6lkrehi 3424 16 we -PRON- PRP cord-335975-m6lkrehi 3424 17 measured measure VBD cord-335975-m6lkrehi 3424 18 CIDoppler CIDoppler NNP cord-335975-m6lkrehi 3424 19 before before RB cord-335975-m6lkrehi 3424 20 and and CC cord-335975-m6lkrehi 3424 21 during during IN cord-335975-m6lkrehi 3424 22 the the DT cord-335975-m6lkrehi 3424 23 5 5 CD cord-335975-m6lkrehi 3424 24 last last JJ cord-335975-m6lkrehi 3424 25 seconds second NNS cord-335975-m6lkrehi 3424 26 of of IN cord-335975-m6lkrehi 3424 27 successive successive JJ cord-335975-m6lkrehi 3424 28 15-second 15-second CD cord-335975-m6lkrehi 3424 29 end end NN cord-335975-m6lkrehi 3424 30 - - HYPH cord-335975-m6lkrehi 3424 31 inspiratory inspiratory JJ cord-335975-m6lkrehi 3424 32 occlusion occlusion NN cord-335975-m6lkrehi 3424 33 ( ( -LRB- cord-335975-m6lkrehi 3424 34 EIO EIO NNP cord-335975-m6lkrehi 3424 35 ) ) -RRB- cord-335975-m6lkrehi 3424 36 and and CC cord-335975-m6lkrehi 3424 37 endexpiratory endexpiratory NNP cord-335975-m6lkrehi 3424 38 occlusion occlusion NN cord-335975-m6lkrehi 3424 39 ( ( -LRB- cord-335975-m6lkrehi 3424 40 EEO EEO NNP cord-335975-m6lkrehi 3424 41 ) ) -RRB- cord-335975-m6lkrehi 3424 42 , , , cord-335975-m6lkrehi 3424 43 separated separate VBN cord-335975-m6lkrehi 3424 44 by by IN cord-335975-m6lkrehi 3424 45 1 1 CD cord-335975-m6lkrehi 3424 46 min min NN cord-335975-m6lkrehi 3424 47 . . . cord-335975-m6lkrehi 3425 1 Patients patient NNS cord-335975-m6lkrehi 3425 2 in in IN cord-335975-m6lkrehi 3425 3 whom whom WP cord-335975-m6lkrehi 3425 4 volume volume NN cord-335975-m6lkrehi 3425 5 expansion expansion NN cord-335975-m6lkrehi 3425 6 increased increase VBD cord-335975-m6lkrehi 3425 7 cardiac cardiac JJ cord-335975-m6lkrehi 3425 8 index index NN cord-335975-m6lkrehi 3425 9 ( ( -LRB- cord-335975-m6lkrehi 3425 10 transpulmonary transpulmonary NNP cord-335975-m6lkrehi 3425 11 thermodilution thermodilution NN cord-335975-m6lkrehi 3425 12 ) ) -RRB- cord-335975-m6lkrehi 3425 13 > > XX cord-335975-m6lkrehi 3425 14 15 15 CD cord-335975-m6lkrehi 3425 15 % % NN cord-335975-m6lkrehi 3425 16 were be VBD cord-335975-m6lkrehi 3425 17 defined define VBN cord-335975-m6lkrehi 3425 18 as as IN cord-335975-m6lkrehi 3425 19 " " `` cord-335975-m6lkrehi 3425 20 fluid fluid JJ cord-335975-m6lkrehi 3425 21 responders responder NNS cord-335975-m6lkrehi 3425 22 " " '' cord-335975-m6lkrehi 3425 23 . . . cord-335975-m6lkrehi 3426 1 Results result NNS cord-335975-m6lkrehi 3426 2 : : : cord-335975-m6lkrehi 3427 1 EEO EEO NNP cord-335975-m6lkrehi 3427 2 increased increase VBD cord-335975-m6lkrehi 3427 3 CIDoppler CIDoppler NNP cord-335975-m6lkrehi 3427 4 more more RBR cord-335975-m6lkrehi 3427 5 in in IN cord-335975-m6lkrehi 3427 6 responders responder NNS cord-335975-m6lkrehi 3427 7 than than IN cord-335975-m6lkrehi 3427 8 in in IN cord-335975-m6lkrehi 3427 9 nonresponders nonresponder NNS cord-335975-m6lkrehi 3427 10 ( ( -LRB- cord-335975-m6lkrehi 3427 11 8 8 CD cord-335975-m6lkrehi 3427 12 ± ± CD cord-335975-m6lkrehi 3427 13 2 2 CD cord-335975-m6lkrehi 3427 14 vs. vs. NN cord-335975-m6lkrehi 3427 15 3 3 CD cord-335975-m6lkrehi 3427 16 ± ± CD cord-335975-m6lkrehi 3427 17 1 1 CD cord-335975-m6lkrehi 3427 18 % % NN cord-335975-m6lkrehi 3427 19 , , , cord-335975-m6lkrehi 3427 20 respectively respectively RB cord-335975-m6lkrehi 3427 21 , , , cord-335975-m6lkrehi 3427 22 p p NN cord-335975-m6lkrehi 3427 23 < < XX cord-335975-m6lkrehi 3427 24 0.0001 0.0001 CD cord-335975-m6lkrehi 3427 25 ) ) -RRB- cord-335975-m6lkrehi 3427 26 and and CC cord-335975-m6lkrehi 3427 27 EIO EIO NNP cord-335975-m6lkrehi 3427 28 decreased decrease VBD cord-335975-m6lkrehi 3427 29 CIDoppler CIDoppler NNP cord-335975-m6lkrehi 3427 30 more more RBR cord-335975-m6lkrehi 3427 31 in in IN cord-335975-m6lkrehi 3427 32 responders responder NNS cord-335975-m6lkrehi 3427 33 than than IN cord-335975-m6lkrehi 3427 34 in in IN cord-335975-m6lkrehi 3427 35 non non NNS cord-335975-m6lkrehi 3427 36 - - NNS cord-335975-m6lkrehi 3427 37 responders responder NNS cord-335975-m6lkrehi 3427 38 ( ( -LRB- cord-335975-m6lkrehi 3427 39 -9 -9 NNP cord-335975-m6lkrehi 3427 40 ± ± NNP cord-335975-m6lkrehi 3427 41 5 5 CD cord-335975-m6lkrehi 3427 42 vs. vs. NN cord-335975-m6lkrehi 3427 43 -4 -4 NN cord-335975-m6lkrehi 3427 44 ± ± CD cord-335975-m6lkrehi 3427 45 2 2 CD cord-335975-m6lkrehi 3427 46 % % NN cord-335975-m6lkrehi 3427 47 , , , cord-335975-m6lkrehi 3427 48 respectively respectively RB cord-335975-m6lkrehi 3427 49 , , , cord-335975-m6lkrehi 3427 50 p p NN cord-335975-m6lkrehi 3427 51 = = SYM cord-335975-m6lkrehi 3427 52 0.0002 0.0002 CD cord-335975-m6lkrehi 3427 53 ) ) -RRB- cord-335975-m6lkrehi 3427 54 . . . cord-335975-m6lkrehi 3428 1 Thus thus RB cord-335975-m6lkrehi 3428 2 , , , cord-335975-m6lkrehi 3428 3 when when WRB cord-335975-m6lkrehi 3428 4 adding add VBG cord-335975-m6lkrehi 3428 5 the the DT cord-335975-m6lkrehi 3428 6 absolute absolute JJ cord-335975-m6lkrehi 3428 7 values value NNS cord-335975-m6lkrehi 3428 8 of of IN cord-335975-m6lkrehi 3428 9 changes change NNS cord-335975-m6lkrehi 3428 10 in in IN cord-335975-m6lkrehi 3428 11 CI CI NNP cord-335975-m6lkrehi 3428 12 observed observe VBD cord-335975-m6lkrehi 3428 13 during during IN cord-335975-m6lkrehi 3428 14 both both DT cord-335975-m6lkrehi 3428 15 occlusions occlusion NNS cord-335975-m6lkrehi 3428 16 , , , cord-335975-m6lkrehi 3428 17 CIDoppler CIDoppler NNP cord-335975-m6lkrehi 3428 18 changed change VBD cord-335975-m6lkrehi 3428 19 by by IN cord-335975-m6lkrehi 3428 20 18 18 CD cord-335975-m6lkrehi 3428 21 ± ± CD cord-335975-m6lkrehi 3428 22 5 5 CD cord-335975-m6lkrehi 3428 23 % % NN cord-335975-m6lkrehi 3428 24 in in IN cord-335975-m6lkrehi 3428 25 responders responder NNS cord-335975-m6lkrehi 3428 26 and and CC cord-335975-m6lkrehi 3428 27 7 7 CD cord-335975-m6lkrehi 3428 28 ± ± CD cord-335975-m6lkrehi 3428 29 2 2 CD cord-335975-m6lkrehi 3428 30 % % NN cord-335975-m6lkrehi 3428 31 in in IN cord-335975-m6lkrehi 3428 32 nonresponders nonresponder NNS cord-335975-m6lkrehi 3428 33 . . . cord-335975-m6lkrehi 3429 1 Fluid fluid JJ cord-335975-m6lkrehi 3429 2 responsiveness responsiveness NN cord-335975-m6lkrehi 3429 3 was be VBD cord-335975-m6lkrehi 3429 4 predicted predict VBN cord-335975-m6lkrehi 3429 5 by by IN cord-335975-m6lkrehi 3429 6 the the DT cord-335975-m6lkrehi 3429 7 EEO EEO NNP cord-335975-m6lkrehi 3429 8 - - HYPH cord-335975-m6lkrehi 3429 9 induced induce VBN cord-335975-m6lkrehi 3429 10 change change NN cord-335975-m6lkrehi 3429 11 in in IN cord-335975-m6lkrehi 3429 12 CIDoppler cidoppler NN cord-335975-m6lkrehi 3429 13 with with IN cord-335975-m6lkrehi 3429 14 an an DT cord-335975-m6lkrehi 3429 15 area area NN cord-335975-m6lkrehi 3429 16 under under IN cord-335975-m6lkrehi 3429 17 the the DT cord-335975-m6lkrehi 3429 18 receiver receiver NN cord-335975-m6lkrehi 3429 19 operating operating NN cord-335975-m6lkrehi 3429 20 characteristic characteristic NN cord-335975-m6lkrehi 3429 21 ( ( -LRB- cord-335975-m6lkrehi 3429 22 ROC ROC NNP cord-335975-m6lkrehi 3429 23 ) ) -RRB- cord-335975-m6lkrehi 3429 24 curve curve NN cord-335975-m6lkrehi 3429 25 of of IN cord-335975-m6lkrehi 3429 26 1.00 1.00 CD cord-335975-m6lkrehi 3429 27 ( ( -LRB- cord-335975-m6lkrehi 3429 28 95 95 CD cord-335975-m6lkrehi 3429 29 % % NN cord-335975-m6lkrehi 3429 30 confidence confidence NN cord-335975-m6lkrehi 3429 31 interval-0.88 interval-0.88 NNP cord-335975-m6lkrehi 3429 32 - - : cord-335975-m6lkrehi 3429 33 1.00 1.00 CD cord-335975-m6lkrehi 3429 34 ) ) -RRB- cord-335975-m6lkrehi 3429 35 and and CC cord-335975-m6lkrehi 3429 36 a a DT cord-335975-m6lkrehi 3429 37 threshold threshold NN cord-335975-m6lkrehi 3429 38 value value NN cord-335975-m6lkrehi 3429 39 of of IN cord-335975-m6lkrehi 3429 40 4 4 CD cord-335975-m6lkrehi 3429 41 % % NN cord-335975-m6lkrehi 3429 42 increase increase NN cord-335975-m6lkrehi 3429 43 in in IN cord-335975-m6lkrehi 3429 44 CIDoppler cidoppler NN cord-335975-m6lkrehi 3429 45 . . . cord-335975-m6lkrehi 3430 1 It -PRON- PRP cord-335975-m6lkrehi 3430 2 was be VBD cord-335975-m6lkrehi 3430 3 predicted predict VBN cord-335975-m6lkrehi 3430 4 by by IN cord-335975-m6lkrehi 3430 5 the the DT cord-335975-m6lkrehi 3430 6 sum sum NN cord-335975-m6lkrehi 3430 7 of of IN cord-335975-m6lkrehi 3430 8 absolute absolute JJ cord-335975-m6lkrehi 3430 9 values value NNS cord-335975-m6lkrehi 3430 10 of of IN cord-335975-m6lkrehi 3430 11 changes change NNS cord-335975-m6lkrehi 3430 12 in in IN cord-335975-m6lkrehi 3430 13 CIDoppler cidoppler NN cord-335975-m6lkrehi 3430 14 during during IN cord-335975-m6lkrehi 3430 15 both both DT cord-335975-m6lkrehi 3430 16 occlusions occlusion NNS cord-335975-m6lkrehi 3430 17 with with IN cord-335975-m6lkrehi 3430 18 a a DT cord-335975-m6lkrehi 3430 19 similar similar JJ cord-335975-m6lkrehi 3430 20 area area NN cord-335975-m6lkrehi 3430 21 under under IN cord-335975-m6lkrehi 3430 22 the the DT cord-335975-m6lkrehi 3430 23 ROC ROC NNP cord-335975-m6lkrehi 3430 24 curve curve NN cord-335975-m6lkrehi 3430 25 ( ( -LRB- cord-335975-m6lkrehi 3430 26 0.99 0.99 CD cord-335975-m6lkrehi 3430 27 ( ( -LRB- cord-335975-m6lkrehi 3430 28 0.86 0.86 CD cord-335975-m6lkrehi 3430 29 - - SYM cord-335975-m6lkrehi 3430 30 1.00 1.00 CD cord-335975-m6lkrehi 3430 31 ) ) -RRB- cord-335975-m6lkrehi 3430 32 ) ) -RRB- cord-335975-m6lkrehi 3430 33 and and CC cord-335975-m6lkrehi 3430 34 with with IN cord-335975-m6lkrehi 3430 35 a a DT cord-335975-m6lkrehi 3430 36 threshold threshold NN cord-335975-m6lkrehi 3430 37 of of IN cord-335975-m6lkrehi 3430 38 9 9 CD cord-335975-m6lkrehi 3430 39 % % NN cord-335975-m6lkrehi 3430 40 change change NN cord-335975-m6lkrehi 3430 41 in in IN cord-335975-m6lkrehi 3430 42 CIDoppler CIDoppler NNP cord-335975-m6lkrehi 3430 43 , , , cord-335975-m6lkrehi 3430 44 which which WDT cord-335975-m6lkrehi 3430 45 is be VBZ cord-335975-m6lkrehi 3430 46 more more RBR cord-335975-m6lkrehi 3430 47 compatible compatible JJ cord-335975-m6lkrehi 3430 48 with with IN cord-335975-m6lkrehi 3430 49 oesophageal oesophageal JJ cord-335975-m6lkrehi 3430 50 Doppler doppler NN cord-335975-m6lkrehi 3430 51 precision precision NN cord-335975-m6lkrehi 3430 52 . . . cord-335975-m6lkrehi 3431 1 In in IN cord-335975-m6lkrehi 3431 2 this this DT cord-335975-m6lkrehi 3431 3 case case NN cord-335975-m6lkrehi 3431 4 , , , cord-335975-m6lkrehi 3431 5 the the DT cord-335975-m6lkrehi 3431 6 sensitivity sensitivity NN cord-335975-m6lkrehi 3431 7 was be VBD cord-335975-m6lkrehi 3431 8 100(77 100(77 CD cord-335975-m6lkrehi 3431 9 - - SYM cord-335975-m6lkrehi 3431 10 100)% 100)% CD cord-335975-m6lkrehi 3431 11 and and CC cord-335975-m6lkrehi 3431 12 the the DT cord-335975-m6lkrehi 3431 13 specificity specificity NN cord-335975-m6lkrehi 3431 14 was be VBD cord-335975-m6lkrehi 3431 15 93(66 93(66 CD cord-335975-m6lkrehi 3431 16 - - HYPH cord-335975-m6lkrehi 3431 17 100)% 100)% CD cord-335975-m6lkrehi 3431 18 . . . cord-335975-m6lkrehi 3432 1 Conclusion conclusion NN cord-335975-m6lkrehi 3432 2 : : : cord-335975-m6lkrehi 3432 3 If if IN cord-335975-m6lkrehi 3432 4 consecutive consecutive JJ cord-335975-m6lkrehi 3432 5 EIO EIO NNP cord-335975-m6lkrehi 3432 6 and and CC cord-335975-m6lkrehi 3432 7 EEO EEO NNP cord-335975-m6lkrehi 3432 8 change change NN cord-335975-m6lkrehi 3432 9 CIDoppler cidoppler NN cord-335975-m6lkrehi 3432 10 > > XX cord-335975-m6lkrehi 3432 11 9 9 CD cord-335975-m6lkrehi 3432 12 % % NN cord-335975-m6lkrehi 3432 13 in in IN cord-335975-m6lkrehi 3432 14 total total NN cord-335975-m6lkrehi 3432 15 , , , cord-335975-m6lkrehi 3432 16 it -PRON- PRP cord-335975-m6lkrehi 3432 17 is be VBZ cord-335975-m6lkrehi 3432 18 very very RB cord-335975-m6lkrehi 3432 19 likely likely JJ cord-335975-m6lkrehi 3432 20 that that IN cord-335975-m6lkrehi 3432 21 volume volume NN cord-335975-m6lkrehi 3432 22 expansion expansion NN cord-335975-m6lkrehi 3432 23 will will MD cord-335975-m6lkrehi 3432 24 be be VB cord-335975-m6lkrehi 3432 25 efficient efficient JJ cord-335975-m6lkrehi 3432 26 in in IN cord-335975-m6lkrehi 3432 27 terms term NNS cord-335975-m6lkrehi 3432 28 of of IN cord-335975-m6lkrehi 3432 29 cardiac cardiac JJ cord-335975-m6lkrehi 3432 30 output output NN cord-335975-m6lkrehi 3432 31 . . . cord-335975-m6lkrehi 3433 1 The the DT cord-335975-m6lkrehi 3433 2 measurement measurement NN cord-335975-m6lkrehi 3433 3 of of IN cord-335975-m6lkrehi 3433 4 cardiac cardiac JJ cord-335975-m6lkrehi 3433 5 output output NN cord-335975-m6lkrehi 3433 6 using use VBG cord-335975-m6lkrehi 3433 7 a a DT cord-335975-m6lkrehi 3433 8 signal signal JJ cord-335975-m6lkrehi 3433 9 morphology morphology NN cord-335975-m6lkrehi 3433 10 - - HYPH cord-335975-m6lkrehi 3433 11 based base VBN cord-335975-m6lkrehi 3433 12 form form NN cord-335975-m6lkrehi 3433 13 of of IN cord-335975-m6lkrehi 3433 14 impedance impedance NN cord-335975-m6lkrehi 3433 15 cardiography cardiography NN cord-335975-m6lkrehi 3433 16 ( ( -LRB- cord-335975-m6lkrehi 3433 17 Physioflow Physioflow NNP cord-335975-m6lkrehi 3433 18 ® ® , cord-335975-m6lkrehi 3433 19 ) ) -RRB- cord-335975-m6lkrehi 3433 20 in in IN cord-335975-m6lkrehi 3433 21 intensive intensive JJ cord-335975-m6lkrehi 3433 22 care care NN cord-335975-m6lkrehi 3433 23 unit unit NN cord-335975-m6lkrehi 3433 24 : : : cord-335975-m6lkrehi 3433 25 comparison comparison NN cord-335975-m6lkrehi 3433 26 with with IN cord-335975-m6lkrehi 3433 27 the the DT cord-335975-m6lkrehi 3433 28 trans trans JJ cord-335975-m6lkrehi 3433 29 thoracic thoracic JJ cord-335975-m6lkrehi 3433 30 echocardiography echocardiography NN cord-335975-m6lkrehi 3433 31 . . . cord-335975-m6lkrehi 3434 1 Introduction introduction NN cord-335975-m6lkrehi 3434 2 : : : cord-335975-m6lkrehi 3435 1 In in IN cord-335975-m6lkrehi 3435 2 the the DT cord-335975-m6lkrehi 3435 3 Intensive intensive JJ cord-335975-m6lkrehi 3435 4 care care NN cord-335975-m6lkrehi 3435 5 units unit NNS cord-335975-m6lkrehi 3435 6 , , , cord-335975-m6lkrehi 3435 7 the the DT cord-335975-m6lkrehi 3435 8 cardiac cardiac JJ cord-335975-m6lkrehi 3435 9 output output NN cord-335975-m6lkrehi 3435 10 ( ( -LRB- cord-335975-m6lkrehi 3435 11 CO CO NNP cord-335975-m6lkrehi 3435 12 ) ) -RRB- cord-335975-m6lkrehi 3435 13 is be VBZ cord-335975-m6lkrehi 3435 14 one one CD cord-335975-m6lkrehi 3435 15 of of IN cord-335975-m6lkrehi 3435 16 the the DT cord-335975-m6lkrehi 3435 17 main main JJ cord-335975-m6lkrehi 3435 18 hemodynamic hemodynamic JJ cord-335975-m6lkrehi 3435 19 parameters parameter NNS cord-335975-m6lkrehi 3435 20 required require VBN cord-335975-m6lkrehi 3435 21 to to TO cord-335975-m6lkrehi 3435 22 manage manage VB cord-335975-m6lkrehi 3435 23 patients patient NNS cord-335975-m6lkrehi 3435 24 in in IN cord-335975-m6lkrehi 3435 25 shock shock NN cord-335975-m6lkrehi 3435 26 . . . cord-335975-m6lkrehi 3436 1 The the DT cord-335975-m6lkrehi 3436 2 Physioflow Physioflow NNP cord-335975-m6lkrehi 3437 1 ® ® NNP cord-335975-m6lkrehi 3437 2 is be VBZ cord-335975-m6lkrehi 3437 3 a a DT cord-335975-m6lkrehi 3437 4 new new JJ cord-335975-m6lkrehi 3437 5 non non JJ cord-335975-m6lkrehi 3437 6 - - JJ cord-335975-m6lkrehi 3437 7 invasive invasive JJ cord-335975-m6lkrehi 3437 8 method method NN cord-335975-m6lkrehi 3437 9 using use VBG cord-335975-m6lkrehi 3437 10 the the DT cord-335975-m6lkrehi 3437 11 waveform waveform NN cord-335975-m6lkrehi 3437 12 analysis analysis NN cord-335975-m6lkrehi 3437 13 of of IN cord-335975-m6lkrehi 3437 14 the the DT cord-335975-m6lkrehi 3437 15 thoracic thoracic JJ cord-335975-m6lkrehi 3437 16 impedance impedance NN cord-335975-m6lkrehi 3437 17 signal signal NN cord-335975-m6lkrehi 3437 18 ( ( -LRB- cord-335975-m6lkrehi 3437 19 TI TI NNP cord-335975-m6lkrehi 3437 20 ) ) -RRB- cord-335975-m6lkrehi 3437 21 to to TO cord-335975-m6lkrehi 3437 22 assess assess VB cord-335975-m6lkrehi 3437 23 CO CO NNP cord-335975-m6lkrehi 3437 24 . . . cord-335975-m6lkrehi 3438 1 In in IN cord-335975-m6lkrehi 3438 2 hemodynamicaly hemodynamicaly NN cord-335975-m6lkrehi 3438 3 unstable unstable JJ cord-335975-m6lkrehi 3438 4 patients patient NNS cord-335975-m6lkrehi 3438 5 , , , cord-335975-m6lkrehi 3438 6 no no DT cord-335975-m6lkrehi 3438 7 studies study NNS cord-335975-m6lkrehi 3438 8 have have VBP cord-335975-m6lkrehi 3438 9 evaluated evaluate VBN cord-335975-m6lkrehi 3438 10 the the DT cord-335975-m6lkrehi 3438 11 level level NN cord-335975-m6lkrehi 3438 12 of of IN cord-335975-m6lkrehi 3438 13 agreement agreement NN cord-335975-m6lkrehi 3438 14 between between IN cord-335975-m6lkrehi 3438 15 the the DT cord-335975-m6lkrehi 3438 16 CO CO NNP cord-335975-m6lkrehi 3438 17 estimated estimate VBN cord-335975-m6lkrehi 3438 18 by by IN cord-335975-m6lkrehi 3438 19 transthoracic transthoracic NNP cord-335975-m6lkrehi 3438 20 echocardiography echocardiography NN cord-335975-m6lkrehi 3439 1 ( ( -LRB- cord-335975-m6lkrehi 3439 2 CO CO NNP cord-335975-m6lkrehi 3439 3 - - HYPH cord-335975-m6lkrehi 3439 4 TTE TTE NNP cord-335975-m6lkrehi 3439 5 ) ) -RRB- cord-335975-m6lkrehi 3439 6 and and CC cord-335975-m6lkrehi 3440 1 that that IN cord-335975-m6lkrehi 3440 2 measured measure VBN cord-335975-m6lkrehi 3440 3 using use VBG cord-335975-m6lkrehi 3440 4 the the DT cord-335975-m6lkrehi 3440 5 waveform waveform NN cord-335975-m6lkrehi 3440 6 analysis analysis NN cord-335975-m6lkrehi 3440 7 of of IN cord-335975-m6lkrehi 3440 8 thoracic thoracic JJ cord-335975-m6lkrehi 3440 9 Impedance Impedance NNP cord-335975-m6lkrehi 3440 10 Physioflow Physioflow NNP cord-335975-m6lkrehi 3440 11 ® ® . cord-335975-m6lkrehi 3440 12 ( ( -LRB- cord-335975-m6lkrehi 3440 13 CO CO NNP cord-335975-m6lkrehi 3440 14 - - HYPH cord-335975-m6lkrehi 3440 15 TI TI NNP cord-335975-m6lkrehi 3440 16 ) ) -RRB- cord-335975-m6lkrehi 3440 17 . . . cord-335975-m6lkrehi 3441 1 The the DT cord-335975-m6lkrehi 3441 2 objective objective NN cord-335975-m6lkrehi 3441 3 of of IN cord-335975-m6lkrehi 3441 4 this this DT cord-335975-m6lkrehi 3441 5 study study NN cord-335975-m6lkrehi 3441 6 was be VBD cord-335975-m6lkrehi 3441 7 to to TO cord-335975-m6lkrehi 3441 8 evaluate evaluate VB cord-335975-m6lkrehi 3441 9 the the DT cord-335975-m6lkrehi 3441 10 ability ability NN cord-335975-m6lkrehi 3441 11 of of IN cord-335975-m6lkrehi 3441 12 CO CO NNP cord-335975-m6lkrehi 3441 13 - - HYPH cord-335975-m6lkrehi 3441 14 TI TI NNP cord-335975-m6lkrehi 3441 15 relative relative NN cord-335975-m6lkrehi 3441 16 to to IN cord-335975-m6lkrehi 3441 17 CO CO NNP cord-335975-m6lkrehi 3441 18 - - HYPH cord-335975-m6lkrehi 3441 19 TTE TTE NNP cord-335975-m6lkrehi 3441 20 to to TO cord-335975-m6lkrehi 3441 21 estimate estimate VB cord-335975-m6lkrehi 3441 22 the the DT cord-335975-m6lkrehi 3441 23 absolute absolute JJ cord-335975-m6lkrehi 3441 24 CO co NN cord-335975-m6lkrehi 3441 25 value value NN cord-335975-m6lkrehi 3441 26 and and CC cord-335975-m6lkrehi 3441 27 detect detect VB cord-335975-m6lkrehi 3441 28 the the DT cord-335975-m6lkrehi 3441 29 expected expect VBN cord-335975-m6lkrehi 3441 30 variation variation NN cord-335975-m6lkrehi 3441 31 CO CO NNP cord-335975-m6lkrehi 3441 32 ( ( -LRB- cord-335975-m6lkrehi 3441 33 V V NNP cord-335975-m6lkrehi 3441 34 - - HYPH cord-335975-m6lkrehi 3441 35 CO CO NNP cord-335975-m6lkrehi 3441 36 ) ) -RRB- cord-335975-m6lkrehi 3441 37 in in IN cord-335975-m6lkrehi 3441 38 critically critically RB cord-335975-m6lkrehi 3441 39 ill ill JJ cord-335975-m6lkrehi 3441 40 patients patient NNS cord-335975-m6lkrehi 3441 41 . . . cord-335975-m6lkrehi 3442 1 Patients patient NNS cord-335975-m6lkrehi 3442 2 and and CC cord-335975-m6lkrehi 3442 3 methods method NNS cord-335975-m6lkrehi 3442 4 : : : cord-335975-m6lkrehi 3442 5 Fourteen fourteen CD cord-335975-m6lkrehi 3442 6 patients patient NNS cord-335975-m6lkrehi 3442 7 sedated sedate VBN cord-335975-m6lkrehi 3442 8 and and CC cord-335975-m6lkrehi 3442 9 mechanically mechanically RB cord-335975-m6lkrehi 3442 10 ventilated ventilate VBN cord-335975-m6lkrehi 3442 11 , , , cord-335975-m6lkrehi 3442 12 in in IN cord-335975-m6lkrehi 3442 13 shock shock NN cord-335975-m6lkrehi 3442 14 under under IN cord-335975-m6lkrehi 3442 15 catecholamines catecholamine NNS cord-335975-m6lkrehi 3442 16 and and CC cord-335975-m6lkrehi 3442 17 monitorred monitorre VBN cord-335975-m6lkrehi 3442 18 with with IN cord-335975-m6lkrehi 3442 19 TTE TTE NNP cord-335975-m6lkrehi 3442 20 and and CC cord-335975-m6lkrehi 3442 21 TI TI NNP cord-335975-m6lkrehi 3442 22 Physioflow Physioflow NNP cord-335975-m6lkrehi 3443 1 ® ® NNS cord-335975-m6lkrehi 3443 2 were be VBD cord-335975-m6lkrehi 3443 3 included include VBN cord-335975-m6lkrehi 3443 4 . . . cord-335975-m6lkrehi 3444 1 Hemodynamic Hemodynamic NNP cord-335975-m6lkrehi 3444 2 datas data NNS cord-335975-m6lkrehi 3444 3 , , , cord-335975-m6lkrehi 3444 4 stroke stroke NN cord-335975-m6lkrehi 3444 5 volume volume NN cord-335975-m6lkrehi 3444 6 ( ( -LRB- cord-335975-m6lkrehi 3444 7 SV SV NNP cord-335975-m6lkrehi 3444 8 ) ) -RRB- cord-335975-m6lkrehi 3444 9 and and CC cord-335975-m6lkrehi 3444 10 CO CO NNP cord-335975-m6lkrehi 3444 11 with with IN cord-335975-m6lkrehi 3444 12 two two CD cord-335975-m6lkrehi 3444 13 monitoring monitoring NN cord-335975-m6lkrehi 3444 14 were be VBD cord-335975-m6lkrehi 3444 15 performed perform VBN cord-335975-m6lkrehi 3444 16 at at IN cord-335975-m6lkrehi 3444 17 baseline baseline JJ cord-335975-m6lkrehi 3444 18 2 2 CD cord-335975-m6lkrehi 3444 19 min min NN cord-335975-m6lkrehi 3444 20 before before IN cord-335975-m6lkrehi 3444 21 passive passive JJ cord-335975-m6lkrehi 3444 22 leg leg NN cord-335975-m6lkrehi 3444 23 raising raise VBG cord-335975-m6lkrehi 3444 24 ( ( -LRB- cord-335975-m6lkrehi 3444 25 PLR PLR NNP cord-335975-m6lkrehi 3444 26 ) ) -RRB- cord-335975-m6lkrehi 3444 27 , , , cord-335975-m6lkrehi 3444 28 30 30 CD cord-335975-m6lkrehi 3444 29 s s NN cord-335975-m6lkrehi 3444 30 after after IN cord-335975-m6lkrehi 3444 31 PLR plr NN cord-335975-m6lkrehi 3444 32 and and CC cord-335975-m6lkrehi 3444 33 2 2 CD cord-335975-m6lkrehi 3444 34 min min NN cord-335975-m6lkrehi 3444 35 after after IN cord-335975-m6lkrehi 3444 36 volume volume NN cord-335975-m6lkrehi 3444 37 expansion expansion NN cord-335975-m6lkrehi 3444 38 ( ( -LRB- cord-335975-m6lkrehi 3444 39 VE VE NNP cord-335975-m6lkrehi 3444 40 ) ) -RRB- cord-335975-m6lkrehi 3444 41 of of IN cord-335975-m6lkrehi 3444 42 500 500 CD cord-335975-m6lkrehi 3444 43 ml ml NNS cord-335975-m6lkrehi 3444 44 of of IN cord-335975-m6lkrehi 3444 45 saline saline NN cord-335975-m6lkrehi 3444 46 solution solution NN cord-335975-m6lkrehi 3444 47 . . . cord-335975-m6lkrehi 3445 1 Responders responder NNS cord-335975-m6lkrehi 3445 2 were be VBD cord-335975-m6lkrehi 3445 3 defined define VBN cord-335975-m6lkrehi 3445 4 by by IN cord-335975-m6lkrehi 3445 5 an an DT cord-335975-m6lkrehi 3445 6 increase increase NN cord-335975-m6lkrehi 3445 7 > > XX cord-335975-m6lkrehi 3445 8 12 12 CD cord-335975-m6lkrehi 3445 9 % % NN cord-335975-m6lkrehi 3445 10 of of IN cord-335975-m6lkrehi 3445 11 cardiac cardiac JJ cord-335975-m6lkrehi 3445 12 output output NN cord-335975-m6lkrehi 3445 13 ( ( -LRB- cord-335975-m6lkrehi 3445 14 V V NNP cord-335975-m6lkrehi 3445 15 - - HYPH cord-335975-m6lkrehi 3445 16 CO co NN cord-335975-m6lkrehi 3445 17 ) ) -RRB- cord-335975-m6lkrehi 3445 18 after after IN cord-335975-m6lkrehi 3445 19 PLR plr NN cord-335975-m6lkrehi 3445 20 . . . cord-335975-m6lkrehi 3446 1 Results result NNS cord-335975-m6lkrehi 3446 2 : : : cord-335975-m6lkrehi 3447 1 Fourteen fourteen CD cord-335975-m6lkrehi 3447 2 pairs pair NNS cord-335975-m6lkrehi 3447 3 of of IN cord-335975-m6lkrehi 3447 4 TTE TTE NNP cord-335975-m6lkrehi 3447 5 and and CC cord-335975-m6lkrehi 3447 6 TI TI NNP cord-335975-m6lkrehi 3447 7 measurements measurement NNS cord-335975-m6lkrehi 3447 8 were be VBD cord-335975-m6lkrehi 3447 9 compared compare VBN cord-335975-m6lkrehi 3447 10 . . . cord-335975-m6lkrehi 3448 1 The the DT cord-335975-m6lkrehi 3448 2 median median NN cord-335975-m6lkrehi 3448 3 ( ( -LRB- cord-335975-m6lkrehi 3448 4 IQR IQR NNP cord-335975-m6lkrehi 3448 5 ) ) -RRB- cord-335975-m6lkrehi 3448 6 age age NN cord-335975-m6lkrehi 3448 7 was be VBD cord-335975-m6lkrehi 3448 8 69 69 CD cord-335975-m6lkrehi 3448 9 years year NNS cord-335975-m6lkrehi 3448 10 ( ( -LRB- cord-335975-m6lkrehi 3448 11 55 55 CD cord-335975-m6lkrehi 3448 12 - - SYM cord-335975-m6lkrehi 3448 13 76 76 CD cord-335975-m6lkrehi 3448 14 ) ) -RRB- cord-335975-m6lkrehi 3448 15 , , . cord-335975-m6lkrehi 3449 1 IGS2 IGS2 NNP cord-335975-m6lkrehi 3449 2 was be VBD cord-335975-m6lkrehi 3449 3 54 54 CD cord-335975-m6lkrehi 3449 4 ( ( -LRB- cord-335975-m6lkrehi 3449 5 40 40 CD cord-335975-m6lkrehi 3449 6 - - SYM cord-335975-m6lkrehi 3449 7 69 69 CD cord-335975-m6lkrehi 3449 8 ) ) -RRB- cord-335975-m6lkrehi 3449 9 . . . cord-335975-m6lkrehi 3450 1 Only only RB cord-335975-m6lkrehi 3450 2 3 3 CD cord-335975-m6lkrehi 3450 3 patients patient NNS cord-335975-m6lkrehi 3450 4 were be VBD cord-335975-m6lkrehi 3450 5 responders responder NNS cord-335975-m6lkrehi 3450 6 after after IN cord-335975-m6lkrehi 3450 7 PLR PLR NNP cord-335975-m6lkrehi 3450 8 . . . cord-335975-m6lkrehi 3451 1 There there EX cord-335975-m6lkrehi 3451 2 was be VBD cord-335975-m6lkrehi 3451 3 a a DT cord-335975-m6lkrehi 3451 4 significant significant JJ cord-335975-m6lkrehi 3451 5 correlation correlation NN cord-335975-m6lkrehi 3451 6 between between IN cord-335975-m6lkrehi 3451 7 the the DT cord-335975-m6lkrehi 3451 8 CO CO NNP cord-335975-m6lkrehi 3451 9 - - HYPH cord-335975-m6lkrehi 3451 10 TTE TTE NNP cord-335975-m6lkrehi 3451 11 and and CC cord-335975-m6lkrehi 3451 12 CO CO NNP cord-335975-m6lkrehi 3451 13 - - HYPH cord-335975-m6lkrehi 3451 14 TI TI NNP cord-335975-m6lkrehi 3451 15 measurements measurement NNS cord-335975-m6lkrehi 3451 16 ( ( -LRB- cord-335975-m6lkrehi 3451 17 r r NN cord-335975-m6lkrehi 3451 18 = = SYM cord-335975-m6lkrehi 3451 19 0.807 0.807 CD cord-335975-m6lkrehi 3451 20 , , , cord-335975-m6lkrehi 3451 21 p p NN cord-335975-m6lkrehi 3451 22 < < XX cord-335975-m6lkrehi 3451 23 0.0001 0.0001 CD cord-335975-m6lkrehi 3451 24 ) ) -RRB- cord-335975-m6lkrehi 3451 25 . . . cord-335975-m6lkrehi 3452 1 The the DT cord-335975-m6lkrehi 3452 2 median median JJ cord-335975-m6lkrehi 3452 3 bias bias NN cord-335975-m6lkrehi 3452 4 was be VBD cord-335975-m6lkrehi 3452 5 0.8 0.8 CD cord-335975-m6lkrehi 3452 6 L l NN cord-335975-m6lkrehi 3452 7 / / SYM cord-335975-m6lkrehi 3452 8 min min NN cord-335975-m6lkrehi 3452 9 and and CC cord-335975-m6lkrehi 3452 10 the the DT cord-335975-m6lkrehi 3452 11 limits limit NNS cord-335975-m6lkrehi 3452 12 of of IN cord-335975-m6lkrehi 3452 13 agreement agreement NN cord-335975-m6lkrehi 3452 14 ( ( -LRB- cord-335975-m6lkrehi 3452 15 LOAs LOAs NNP cord-335975-m6lkrehi 3452 16 ) ) -RRB- cord-335975-m6lkrehi 3452 17 were be VBD cord-335975-m6lkrehi 3452 18 −3.5 −3.5 NN cord-335975-m6lkrehi 3452 19 and and CC cord-335975-m6lkrehi 3452 20 1.9 1.9 CD cord-335975-m6lkrehi 3452 21 L l NN cord-335975-m6lkrehi 3452 22 / / SYM cord-335975-m6lkrehi 3452 23 min min NN cord-335975-m6lkrehi 3452 24 . . . cord-335975-m6lkrehi 3453 1 There there EX cord-335975-m6lkrehi 3453 2 was be VBD cord-335975-m6lkrehi 3453 3 a a DT cord-335975-m6lkrehi 3453 4 significant significant JJ cord-335975-m6lkrehi 3453 5 correlation correlation NN cord-335975-m6lkrehi 3453 6 between between IN cord-335975-m6lkrehi 3453 7 V v NN cord-335975-m6lkrehi 3453 8 - - HYPH cord-335975-m6lkrehi 3453 9 CO co NN cord-335975-m6lkrehi 3453 10 - - HYPH cord-335975-m6lkrehi 3453 11 TTE TTE NNP cord-335975-m6lkrehi 3453 12 and and CC cord-335975-m6lkrehi 3453 13 V V NNP cord-335975-m6lkrehi 3453 14 - - HYPH cord-335975-m6lkrehi 3453 15 CO co NN cord-335975-m6lkrehi 3453 16 - - HYPH cord-335975-m6lkrehi 3453 17 TI TI NNP cord-335975-m6lkrehi 3453 18 ( ( -LRB- cord-335975-m6lkrehi 3453 19 r r NN cord-335975-m6lkrehi 3453 20 = = SYM cord-335975-m6lkrehi 3453 21 0.77 0.77 CD cord-335975-m6lkrehi 3453 22 , , , cord-335975-m6lkrehi 3453 23 p p NN cord-335975-m6lkrehi 3453 24 = = SYM cord-335975-m6lkrehi 3453 25 0.0022 0.0022 CD cord-335975-m6lkrehi 3453 26 ) ) -RRB- cord-335975-m6lkrehi 3454 1 ( ( -LRB- cord-335975-m6lkrehi 3454 2 Fig Fig NNP cord-335975-m6lkrehi 3454 3 . . NNP cord-335975-m6lkrehi 3454 4 1 1 CD cord-335975-m6lkrehi 3454 5 ) ) -RRB- cord-335975-m6lkrehi 3454 6 . . . cord-335975-m6lkrehi 3455 1 The the DT cord-335975-m6lkrehi 3455 2 median median JJ cord-335975-m6lkrehi 3455 3 bias bias NN cord-335975-m6lkrehi 3455 4 was-5.2 was-5.2 NNP cord-335975-m6lkrehi 3455 5 % % NN cord-335975-m6lkrehi 3455 6 and and CC cord-335975-m6lkrehi 3455 7 the the DT cord-335975-m6lkrehi 3455 8 LOAs loa NNS cord-335975-m6lkrehi 3455 9 for for IN cord-335975-m6lkrehi 3455 10 V V NNP cord-335975-m6lkrehi 3455 11 - - HYPH cord-335975-m6lkrehi 3455 12 CO CO NNP cord-335975-m6lkrehi 3455 13 were be VBD cord-335975-m6lkrehi 3455 14 respectively respectively RB cord-335975-m6lkrehi 3455 15 -26.5 -26.5 NNS cord-335975-m6lkrehi 3455 16 and and CC cord-335975-m6lkrehi 3455 17 +16.5 +16.5 NFP cord-335975-m6lkrehi 3455 18 % % NN cord-335975-m6lkrehi 3455 19 . . . cord-335975-m6lkrehi 3456 1 Conclusion conclusion NN cord-335975-m6lkrehi 3456 2 : : : cord-335975-m6lkrehi 3457 1 The the DT cord-335975-m6lkrehi 3457 2 CO CO NNP cord-335975-m6lkrehi 3457 3 measured measure VBN cord-335975-m6lkrehi 3457 4 with with IN cord-335975-m6lkrehi 3457 5 PhysioFlow PhysioFlow NNP cord-335975-m6lkrehi 3457 6 ® ® NNP cord-335975-m6lkrehi 3457 7 , , , cord-335975-m6lkrehi 3457 8 a a DT cord-335975-m6lkrehi 3457 9 signal signal JJ cord-335975-m6lkrehi 3457 10 morphology morphology NN cord-335975-m6lkrehi 3457 11 - - HYPH cord-335975-m6lkrehi 3457 12 based base VBN cord-335975-m6lkrehi 3457 13 impedance impedance NN cord-335975-m6lkrehi 3457 14 cardiography cardiography NN cord-335975-m6lkrehi 3457 15 , , , cord-335975-m6lkrehi 3457 16 is be VBZ cord-335975-m6lkrehi 3457 17 correlated correlate VBN cord-335975-m6lkrehi 3457 18 to to IN cord-335975-m6lkrehi 3457 19 the the DT cord-335975-m6lkrehi 3457 20 CO CO NNP cord-335975-m6lkrehi 3457 21 measured measure VBN cord-335975-m6lkrehi 3457 22 with with IN cord-335975-m6lkrehi 3457 23 TTE TTE NNP cord-335975-m6lkrehi 3457 24 . . . cord-335975-m6lkrehi 3458 1 However however RB cord-335975-m6lkrehi 3458 2 , , , cord-335975-m6lkrehi 3458 3 the the DT cord-335975-m6lkrehi 3458 4 high high JJ cord-335975-m6lkrehi 3458 5 LOA LOA NNP cord-335975-m6lkrehi 3458 6 observed observe VBD cord-335975-m6lkrehi 3458 7 in in IN cord-335975-m6lkrehi 3458 8 this this DT cord-335975-m6lkrehi 3458 9 preliminary preliminary JJ cord-335975-m6lkrehi 3458 10 study study NN cord-335975-m6lkrehi 3458 11 underline underline VBP cord-335975-m6lkrehi 3458 12 the the DT cord-335975-m6lkrehi 3458 13 necessity necessity NN cord-335975-m6lkrehi 3458 14 to to TO cord-335975-m6lkrehi 3458 15 remain remain VB cord-335975-m6lkrehi 3458 16 careful careful JJ cord-335975-m6lkrehi 3458 17 and and CC cord-335975-m6lkrehi 3458 18 wait wait VB cord-335975-m6lkrehi 3458 19 for for IN cord-335975-m6lkrehi 3458 20 further further JJ cord-335975-m6lkrehi 3458 21 inclusions inclusion NNS cord-335975-m6lkrehi 3458 22 . . . cord-335975-m6lkrehi 3459 1 -9 -9 NNP cord-335975-m6lkrehi 3459 2 ] ] -RRB- cord-335975-m6lkrehi 3460 1 vs. vs. FW cord-335975-m6lkrehi 3460 2 5.5 5.5 CD cord-335975-m6lkrehi 3460 3 [ [ -LRB- cord-335975-m6lkrehi 3460 4 2 2 CD cord-335975-m6lkrehi 3460 5 ] ] -RRB- cord-335975-m6lkrehi 3460 6 [ [ -LRB- cord-335975-m6lkrehi 3460 7 3 3 CD cord-335975-m6lkrehi 3460 8 ] ] -RRB- cord-335975-m6lkrehi 3460 9 [ [ -LRB- cord-335975-m6lkrehi 3460 10 4 4 CD cord-335975-m6lkrehi 3460 11 ] ] -RRB- cord-335975-m6lkrehi 3460 12 [ [ -LRB- cord-335975-m6lkrehi 3460 13 5 5 CD cord-335975-m6lkrehi 3460 14 ] ] -RRB- cord-335975-m6lkrehi 3460 15 [ [ -LRB- cord-335975-m6lkrehi 3460 16 6 6 CD cord-335975-m6lkrehi 3460 17 ] ] -RRB- cord-335975-m6lkrehi 3460 18 [ [ -LRB- cord-335975-m6lkrehi 3460 19 7 7 CD cord-335975-m6lkrehi 3460 20 ] ] -RRB- cord-335975-m6lkrehi 3461 1 [ [ -LRB- cord-335975-m6lkrehi 3461 2 8 8 CD cord-335975-m6lkrehi 3461 3 ] ] -RRB- cord-335975-m6lkrehi 3461 4 [ [ -LRB- cord-335975-m6lkrehi 3461 5 9 9 CD cord-335975-m6lkrehi 3461 6 ] ] -RRB- cord-335975-m6lkrehi 3461 7 [ [ -LRB- cord-335975-m6lkrehi 3461 8 10 10 CD cord-335975-m6lkrehi 3461 9 ] ] -RRB- cord-335975-m6lkrehi 3462 1 [ [ -LRB- cord-335975-m6lkrehi 3462 2 11 11 CD cord-335975-m6lkrehi 3462 3 ] ] -RRB- cord-335975-m6lkrehi 3462 4 days day NNS cord-335975-m6lkrehi 3462 5 , , , cord-335975-m6lkrehi 3462 6 p p NN cord-335975-m6lkrehi 3462 7 = = SYM cord-335975-m6lkrehi 3462 8 0.05 0.05 CD cord-335975-m6lkrehi 3462 9 ) ) -RRB- cord-335975-m6lkrehi 3462 10 . . . cord-335975-m6lkrehi 3463 1 Despite despite IN cord-335975-m6lkrehi 3463 2 imbalancedunderlying imbalancedunderlye VBG cord-335975-m6lkrehi 3463 3 characteristics characteristic NNS cord-335975-m6lkrehi 3463 4 in in IN cord-335975-m6lkrehi 3463 5 terms term NNS cord-335975-m6lkrehi 3463 6 of of IN cord-335975-m6lkrehi 3463 7 demographics demographic NNS cord-335975-m6lkrehi 3463 8 and and CC cord-335975-m6lkrehi 3463 9 comorbidities comorbiditie NNS cord-335975-m6lkrehi 3463 10 , , , cord-335975-m6lkrehi 3463 11 in in IN cord-335975-m6lkrehi 3463 12 - - HYPH cord-335975-m6lkrehi 3463 13 ICU ICU NNP cord-335975-m6lkrehi 3463 14 mortality mortality NN cord-335975-m6lkrehi 3463 15 rates rate NNS cord-335975-m6lkrehi 3463 16 were be VBD cord-335975-m6lkrehi 3463 17 similar similar JJ cord-335975-m6lkrehi 3463 18 between between IN cord-335975-m6lkrehi 3463 19 patients patient NNS cord-335975-m6lkrehi 3463 20 ( ( -LRB- cord-335975-m6lkrehi 3463 21 35.7 35.7 CD cord-335975-m6lkrehi 3463 22 vs. vs. CC cord-335975-m6lkrehi 3463 23 37 37 CD cord-335975-m6lkrehi 3463 24 % % NN cord-335975-m6lkrehi 3463 25 , , , cord-335975-m6lkrehi 3463 26 p p NN cord-335975-m6lkrehi 3463 27 = = SYM cord-335975-m6lkrehi 3463 28 0.75 0.75 CD cord-335975-m6lkrehi 3463 29 ) ) -RRB- cord-335975-m6lkrehi 3463 30 . . . cord-335975-m6lkrehi 3464 1 Conclusion conclusion NN cord-335975-m6lkrehi 3464 2 : : : cord-335975-m6lkrehi 3464 3 Prior Prior NNP cord-335975-m6lkrehi 3464 4 BB BB NNP cord-335975-m6lkrehi 3464 5 treatment treatment NN cord-335975-m6lkrehi 3464 6 have have VBP cord-335975-m6lkrehi 3464 7 limited limit VBN cord-335975-m6lkrehi 3464 8 impact impact NN cord-335975-m6lkrehi 3464 9 on on IN cord-335975-m6lkrehi 3464 10 the the DT cord-335975-m6lkrehi 3464 11 severity severity NN cord-335975-m6lkrehi 3464 12 of of IN cord-335975-m6lkrehi 3464 13 acute acute JJ cord-335975-m6lkrehi 3464 14 circulatory circulatory JJ cord-335975-m6lkrehi 3464 15 failure failure NN cord-335975-m6lkrehi 3464 16 in in IN cord-335975-m6lkrehi 3464 17 septic septic JJ cord-335975-m6lkrehi 3464 18 shock shock NN cord-335975-m6lkrehi 3464 19 and and CC cord-335975-m6lkrehi 3464 20 is be VBZ cord-335975-m6lkrehi 3464 21 not not RB cord-335975-m6lkrehi 3464 22 associated associate VBN cord-335975-m6lkrehi 3464 23 with with IN cord-335975-m6lkrehi 3464 24 increased increase VBN cord-335975-m6lkrehi 3464 25 mortality mortality NN cord-335975-m6lkrehi 3464 26 despite despite IN cord-335975-m6lkrehi 3464 27 the the DT cord-335975-m6lkrehi 3464 28 underlying underlie VBG cord-335975-m6lkrehi 3464 29 frailty frailty NN cord-335975-m6lkrehi 3464 30 of of IN cord-335975-m6lkrehi 3464 31 patients patient NNS cord-335975-m6lkrehi 3464 32 . . . cord-335975-m6lkrehi 3465 1 Introduction introduction NN cord-335975-m6lkrehi 3465 2 : : : cord-335975-m6lkrehi 3466 1 Cardiac cardiac JJ cord-335975-m6lkrehi 3466 2 output output NN cord-335975-m6lkrehi 3466 3 monitoring monitoring NN cord-335975-m6lkrehi 3466 4 is be VBZ cord-335975-m6lkrehi 3466 5 a a DT cord-335975-m6lkrehi 3466 6 key key JJ cord-335975-m6lkrehi 3466 7 component component NN cord-335975-m6lkrehi 3466 8 in in IN cord-335975-m6lkrehi 3466 9 the the DT cord-335975-m6lkrehi 3466 10 management management NN cord-335975-m6lkrehi 3466 11 of of IN cord-335975-m6lkrehi 3466 12 critically critically RB cord-335975-m6lkrehi 3466 13 ill ill JJ cord-335975-m6lkrehi 3466 14 patients patient NNS cord-335975-m6lkrehi 3466 15 . . . cord-335975-m6lkrehi 3467 1 Cardiac cardiac JJ cord-335975-m6lkrehi 3467 2 output output NN cord-335975-m6lkrehi 3467 3 estimated estimate VBN cord-335975-m6lkrehi 3467 4 by by IN cord-335975-m6lkrehi 3467 5 transthoracic transthoracic NNP cord-335975-m6lkrehi 3467 6 echocardiography echocardiography NN cord-335975-m6lkrehi 3467 7 is be VBZ cord-335975-m6lkrehi 3467 8 documented document VBN cord-335975-m6lkrehi 3467 9 in in IN cord-335975-m6lkrehi 3467 10 patient patient NN cord-335975-m6lkrehi 3467 11 with with IN cord-335975-m6lkrehi 3467 12 atrial atrial JJ cord-335975-m6lkrehi 3467 13 fibrillation fibrillation NN cord-335975-m6lkrehi 3467 14 , , , cord-335975-m6lkrehi 3467 15 but but CC cord-335975-m6lkrehi 3467 16 a a DT cord-335975-m6lkrehi 3467 17 large large JJ cord-335975-m6lkrehi 3467 18 part part NN cord-335975-m6lkrehi 3467 19 of of IN cord-335975-m6lkrehi 3467 20 transpulmonary transpulmonary NNP cord-335975-m6lkrehi 3467 21 thermodilution thermodilution NNP cord-335975-m6lkrehi 3467 22 validation validation NN cord-335975-m6lkrehi 3467 23 studies study NNS cord-335975-m6lkrehi 3467 24 excluded exclude VBD cord-335975-m6lkrehi 3467 25 this this DT cord-335975-m6lkrehi 3467 26 specific specific JJ cord-335975-m6lkrehi 3467 27 population population NN cord-335975-m6lkrehi 3467 28 . . . cord-335975-m6lkrehi 3468 1 The the DT cord-335975-m6lkrehi 3468 2 objective objective NN cord-335975-m6lkrehi 3468 3 of of IN cord-335975-m6lkrehi 3468 4 this this DT cord-335975-m6lkrehi 3468 5 study study NN cord-335975-m6lkrehi 3468 6 was be VBD cord-335975-m6lkrehi 3468 7 to to TO cord-335975-m6lkrehi 3468 8 evaluate evaluate VB cord-335975-m6lkrehi 3468 9 cardiac cardiac JJ cord-335975-m6lkrehi 3468 10 output output NN cord-335975-m6lkrehi 3468 11 mesurement mesurement NN cord-335975-m6lkrehi 3468 12 and and CC cord-335975-m6lkrehi 3468 13 trend trend NN cord-335975-m6lkrehi 3468 14 ability ability NN cord-335975-m6lkrehi 3468 15 by by IN cord-335975-m6lkrehi 3468 16 transpulmonary transpulmonary NNP cord-335975-m6lkrehi 3468 17 thermodilution thermodilution NN cord-335975-m6lkrehi 3468 18 relative relative JJ cord-335975-m6lkrehi 3468 19 to to IN cord-335975-m6lkrehi 3468 20 transthoracic transthoracic VB cord-335975-m6lkrehi 3468 21 echocardiography echocardiography NN cord-335975-m6lkrehi 3468 22 in in IN cord-335975-m6lkrehi 3468 23 critically critically RB cord-335975-m6lkrehi 3468 24 ill ill JJ cord-335975-m6lkrehi 3468 25 mechanically mechanically RB cord-335975-m6lkrehi 3468 26 ventilated ventilate VBN cord-335975-m6lkrehi 3468 27 patients patient NNS cord-335975-m6lkrehi 3468 28 with with IN cord-335975-m6lkrehi 3468 29 atrial atrial JJ cord-335975-m6lkrehi 3468 30 fibrillation fibrillation NN cord-335975-m6lkrehi 3468 31 . . . cord-335975-m6lkrehi 3469 1 Patients patient NNS cord-335975-m6lkrehi 3469 2 and and CC cord-335975-m6lkrehi 3469 3 methods method NNS cord-335975-m6lkrehi 3469 4 : : : cord-335975-m6lkrehi 3469 5 Thirty thirty CD cord-335975-m6lkrehi 3469 6 mechanically mechanically RB cord-335975-m6lkrehi 3469 7 ventilated ventilate VBD cord-335975-m6lkrehi 3469 8 patients patient NNS cord-335975-m6lkrehi 3469 9 requiring require VBG cord-335975-m6lkrehi 3469 10 hemodynamic hemodynamic JJ cord-335975-m6lkrehi 3469 11 assessment assessment NN cord-335975-m6lkrehi 3469 12 were be VBD cord-335975-m6lkrehi 3469 13 included include VBN cord-335975-m6lkrehi 3469 14 in in IN cord-335975-m6lkrehi 3469 15 a a DT cord-335975-m6lkrehi 3469 16 prospective prospective JJ cord-335975-m6lkrehi 3469 17 observational observational JJ cord-335975-m6lkrehi 3469 18 study study NN cord-335975-m6lkrehi 3469 19 . . . cord-335975-m6lkrehi 3470 1 Cardiac cardiac JJ cord-335975-m6lkrehi 3470 2 output output NN cord-335975-m6lkrehi 3470 3 was be VBD cord-335975-m6lkrehi 3470 4 mesured mesure VBN cord-335975-m6lkrehi 3470 5 simultaneously simultaneously RB cord-335975-m6lkrehi 3470 6 with with IN cord-335975-m6lkrehi 3470 7 transpulmonary transpulmonary NNP cord-335975-m6lkrehi 3470 8 thermodilution thermodilution NN cord-335975-m6lkrehi 3470 9 and and CC cord-335975-m6lkrehi 3470 10 transthoracic transthoracic NNP cord-335975-m6lkrehi 3470 11 echocardiography echocardiography NN cord-335975-m6lkrehi 3470 12 . . . cord-335975-m6lkrehi 3471 1 Seventy seventy CD cord-335975-m6lkrehi 3471 2 - - HYPH cord-335975-m6lkrehi 3471 3 four four CD cord-335975-m6lkrehi 3471 4 pairs pair NNS cord-335975-m6lkrehi 3471 5 of of IN cord-335975-m6lkrehi 3471 6 cardiac cardiac JJ cord-335975-m6lkrehi 3471 7 output output NN cord-335975-m6lkrehi 3471 8 measurements measurement NNS cord-335975-m6lkrehi 3471 9 were be VBD cord-335975-m6lkrehi 3471 10 compared compare VBN cord-335975-m6lkrehi 3471 11 . . . cord-335975-m6lkrehi 3472 1 The the DT cord-335975-m6lkrehi 3472 2 two two CD cord-335975-m6lkrehi 3472 3 measurements measurement NNS cord-335975-m6lkrehi 3472 4 were be VBD cord-335975-m6lkrehi 3472 5 significantly significantly RB cord-335975-m6lkrehi 3472 6 correlated correlate VBN cord-335975-m6lkrehi 3472 7 ( ( -LRB- cord-335975-m6lkrehi 3472 8 r r NN cord-335975-m6lkrehi 3472 9 = = SYM cord-335975-m6lkrehi 3472 10 0.769 0.769 CD cord-335975-m6lkrehi 3472 11 et et NN cord-335975-m6lkrehi 3472 12 p p NN cord-335975-m6lkrehi 3472 13 < < XX cord-335975-m6lkrehi 3472 14 0.0001 0.0001 CD cord-335975-m6lkrehi 3472 15 ) ) -RRB- cord-335975-m6lkrehi 3472 16 . . . cord-335975-m6lkrehi 3473 1 The the DT cord-335975-m6lkrehi 3473 2 mean mean JJ cord-335975-m6lkrehi 3473 3 bias bias NN cord-335975-m6lkrehi 3473 4 was be VBD cord-335975-m6lkrehi 3473 5 -0.7 -0.7 NNP cord-335975-m6lkrehi 3473 6 l l NNP cord-335975-m6lkrehi 3473 7 / / SYM cord-335975-m6lkrehi 3473 8 min min NNP cord-335975-m6lkrehi 3473 9 , , , cord-335975-m6lkrehi 3473 10 the the DT cord-335975-m6lkrehi 3473 11 limits limit NNS cord-335975-m6lkrehi 3473 12 of of IN cord-335975-m6lkrehi 3473 13 agreement agreement NN cord-335975-m6lkrehi 3473 14 were be VBD cord-335975-m6lkrehi 3473 15 -2.9 -2.9 NNP cord-335975-m6lkrehi 3473 16 and and CC cord-335975-m6lkrehi 3473 17 +1.6 +1.6 NNP cord-335975-m6lkrehi 3473 18 l l NNP cord-335975-m6lkrehi 3473 19 / / SYM cord-335975-m6lkrehi 3473 20 min min NNP cord-335975-m6lkrehi 3473 21 , , , cord-335975-m6lkrehi 3473 22 and and CC cord-335975-m6lkrehi 3473 23 the the DT cord-335975-m6lkrehi 3473 24 percentage percentage NN cord-335975-m6lkrehi 3473 25 error error NN cord-335975-m6lkrehi 3473 26 was be VBD cord-335975-m6lkrehi 3473 27 39.81 39.81 CD cord-335975-m6lkrehi 3473 28 % % NN cord-335975-m6lkrehi 3473 29 . . . cord-335975-m6lkrehi 3474 1 Thirty thirty CD cord-335975-m6lkrehi 3474 2 - - HYPH cord-335975-m6lkrehi 3474 3 four four CD cord-335975-m6lkrehi 3474 4 pairs pair NNS cord-335975-m6lkrehi 3474 5 of of IN cord-335975-m6lkrehi 3474 6 cardiac cardiac JJ cord-335975-m6lkrehi 3474 7 output output NN cord-335975-m6lkrehi 3474 8 variation variation NN cord-335975-m6lkrehi 3474 9 measurements measurement NNS cord-335975-m6lkrehi 3474 10 were be VBD cord-335975-m6lkrehi 3474 11 compared compare VBN cord-335975-m6lkrehi 3474 12 . . . cord-335975-m6lkrehi 3475 1 There there EX cord-335975-m6lkrehi 3475 2 was be VBD cord-335975-m6lkrehi 3475 3 no no DT cord-335975-m6lkrehi 3475 4 significant significant JJ cord-335975-m6lkrehi 3475 5 correlation correlation NN cord-335975-m6lkrehi 3475 6 between between IN cord-335975-m6lkrehi 3475 7 cardiac cardiac JJ cord-335975-m6lkrehi 3475 8 output output NN cord-335975-m6lkrehi 3475 9 variation variation NN cord-335975-m6lkrehi 3475 10 measurements measurement NNS cord-335975-m6lkrehi 3475 11 by by IN cord-335975-m6lkrehi 3475 12 transpulmonary transpulmonary NNP cord-335975-m6lkrehi 3475 13 thermodilution thermodilution NN cord-335975-m6lkrehi 3475 14 and and CC cord-335975-m6lkrehi 3475 15 transthoracic transthoracic NNP cord-335975-m6lkrehi 3475 16 echocardiography echocardiography NN cord-335975-m6lkrehi 3475 17 . . . cord-335975-m6lkrehi 3476 1 The the DT cord-335975-m6lkrehi 3476 2 mean mean JJ cord-335975-m6lkrehi 3476 3 bias bias NN cord-335975-m6lkrehi 3476 4 was be VBD cord-335975-m6lkrehi 3476 5 −0.19 −0.19 NNP cord-335975-m6lkrehi 3476 6 l/ l/ NNP cord-335975-m6lkrehi 3476 7 min min NNP cord-335975-m6lkrehi 3476 8 and and CC cord-335975-m6lkrehi 3476 9 the the DT cord-335975-m6lkrehi 3476 10 limits limit NNS cord-335975-m6lkrehi 3476 11 of of IN cord-335975-m6lkrehi 3476 12 agreement agreement NN cord-335975-m6lkrehi 3476 13 were be VBD cord-335975-m6lkrehi 3477 1 −1.82 −1.82 NNP cord-335975-m6lkrehi 3477 2 and and CC cord-335975-m6lkrehi 3477 3 +1.43 +1.43 NNP cord-335975-m6lkrehi 3477 4 l l NNP cord-335975-m6lkrehi 3477 5 / / SYM cord-335975-m6lkrehi 3477 6 min min NN cord-335975-m6lkrehi 3477 7 . . . cord-335975-m6lkrehi 3478 1 With with IN cord-335975-m6lkrehi 3478 2 a a DT cord-335975-m6lkrehi 3478 3 15 15 CD cord-335975-m6lkrehi 3478 4 % % NN cord-335975-m6lkrehi 3478 5 exclusion exclusion NN cord-335975-m6lkrehi 3478 6 zone zone NN cord-335975-m6lkrehi 3478 7 , , , cord-335975-m6lkrehi 3478 8 the the DT cord-335975-m6lkrehi 3478 9 four four CD cord-335975-m6lkrehi 3478 10 - - HYPH cord-335975-m6lkrehi 3478 11 quadrant quadrant NN cord-335975-m6lkrehi 3478 12 plot plot NN cord-335975-m6lkrehi 3478 13 had have VBD cord-335975-m6lkrehi 3478 14 a a DT cord-335975-m6lkrehi 3478 15 concordance concordance NN cord-335975-m6lkrehi 3478 16 rate rate NN cord-335975-m6lkrehi 3478 17 of of IN cord-335975-m6lkrehi 3478 18 78.6 78.6 CD cord-335975-m6lkrehi 3478 19 % % NN cord-335975-m6lkrehi 3478 20 . . . cord-335975-m6lkrehi 3479 1 The the DT cord-335975-m6lkrehi 3479 2 polar polar JJ cord-335975-m6lkrehi 3479 3 plot plot NN cord-335975-m6lkrehi 3479 4 had have VBD cord-335975-m6lkrehi 3479 5 a a DT cord-335975-m6lkrehi 3479 6 mean mean JJ cord-335975-m6lkrehi 3479 7 polar polar JJ cord-335975-m6lkrehi 3479 8 angle angle NN cord-335975-m6lkrehi 3479 9 of of IN cord-335975-m6lkrehi 3479 10 14.2 14.2 CD cord-335975-m6lkrehi 3479 11 ° ° NNS cord-335975-m6lkrehi 3479 12 with with IN cord-335975-m6lkrehi 3479 13 95 95 CD cord-335975-m6lkrehi 3479 14 % % NN cord-335975-m6lkrehi 3479 15 confidence confidence NN cord-335975-m6lkrehi 3479 16 interval interval NN cord-335975-m6lkrehi 3479 17 between between IN cord-335975-m6lkrehi 3479 18 − − NNP cord-335975-m6lkrehi 3479 19 14.2 14.2 CD cord-335975-m6lkrehi 3479 20 ° ° NNS cord-335975-m6lkrehi 3479 21 and and CC cord-335975-m6lkrehi 3479 22 42.7 42.7 CD cord-335975-m6lkrehi 3479 23 ° ° NNS cord-335975-m6lkrehi 3479 24 . . . cord-335975-m6lkrehi 3480 1 Conclusion conclusion NN cord-335975-m6lkrehi 3480 2 : : : cord-335975-m6lkrehi 3480 3 In in IN cord-335975-m6lkrehi 3480 4 critically critically RB cord-335975-m6lkrehi 3480 5 ill ill JJ cord-335975-m6lkrehi 3480 6 mechanically mechanically RB cord-335975-m6lkrehi 3480 7 ventilated ventilate VBN cord-335975-m6lkrehi 3480 8 patients patient NNS cord-335975-m6lkrehi 3480 9 with with IN cord-335975-m6lkrehi 3480 10 atrial atrial JJ cord-335975-m6lkrehi 3480 11 fibrillation fibrillation NN cord-335975-m6lkrehi 3480 12 , , , cord-335975-m6lkrehi 3480 13 cardiac cardiac JJ cord-335975-m6lkrehi 3480 14 output output NN cord-335975-m6lkrehi 3480 15 measurements measurement NNS cord-335975-m6lkrehi 3480 16 with with IN cord-335975-m6lkrehi 3480 17 transpulmonary transpulmonary NNP cord-335975-m6lkrehi 3480 18 thermodilution thermodilution NN cord-335975-m6lkrehi 3480 19 and and CC cord-335975-m6lkrehi 3480 20 transthoracic transthoracic NNP cord-335975-m6lkrehi 3480 21 echocardiography echocardiography NN cord-335975-m6lkrehi 3480 22 are be VBP cord-335975-m6lkrehi 3480 23 not not RB cord-335975-m6lkrehi 3480 24 interchangeable interchangeable JJ cord-335975-m6lkrehi 3480 25 . . . cord-335975-m6lkrehi 3481 1 Introduction introduction NN cord-335975-m6lkrehi 3481 2 : : : cord-335975-m6lkrehi 3482 1 Basic basic JJ cord-335975-m6lkrehi 3482 2 critical critical JJ cord-335975-m6lkrehi 3482 3 care care NN cord-335975-m6lkrehi 3482 4 echocardiography echocardiography NN cord-335975-m6lkrehi 3482 5 ( ( -LRB- cord-335975-m6lkrehi 3482 6 CCE CCE NNP cord-335975-m6lkrehi 3482 7 ) ) -RRB- cord-335975-m6lkrehi 3482 8 relies rely VBZ cord-335975-m6lkrehi 3482 9 on on IN cord-335975-m6lkrehi 3482 10 transthoracic transthoracic NN cord-335975-m6lkrehi 3482 11 echocardiography echocardiography NN cord-335975-m6lkrehi 3482 12 ( ( -LRB- cord-335975-m6lkrehi 3482 13 TTE TTE NNP cord-335975-m6lkrehi 3482 14 ) ) -RRB- cord-335975-m6lkrehi 3482 15 . . . cord-335975-m6lkrehi 3483 1 We -PRON- PRP cord-335975-m6lkrehi 3483 2 sought seek VBD cord-335975-m6lkrehi 3483 3 to to TO cord-335975-m6lkrehi 3483 4 assess assess VB cord-335975-m6lkrehi 3483 5 the the DT cord-335975-m6lkrehi 3483 6 diagnostic diagnostic JJ cord-335975-m6lkrehi 3483 7 capacity capacity NN cord-335975-m6lkrehi 3483 8 of of IN cord-335975-m6lkrehi 3483 9 a a DT cord-335975-m6lkrehi 3483 10 next next JJ cord-335975-m6lkrehi 3483 11 - - HYPH cord-335975-m6lkrehi 3483 12 generation generation NN cord-335975-m6lkrehi 3483 13 micro micro JJ cord-335975-m6lkrehi 3483 14 - - JJ cord-335975-m6lkrehi 3483 15 digital digital JJ cord-335975-m6lkrehi 3483 16 broadband broadband NN cord-335975-m6lkrehi 3483 17 beamformer beamformer NN cord-335975-m6lkrehi 3483 18 in in IN cord-335975-m6lkrehi 3483 19 patients patient NNS cord-335975-m6lkrehi 3483 20 with with IN cord-335975-m6lkrehi 3483 21 cardiopulmonary cardiopulmonary JJ cord-335975-m6lkrehi 3483 22 compromise compromise NN cord-335975-m6lkrehi 3483 23 . . . cord-335975-m6lkrehi 3484 1 All all DT cord-335975-m6lkrehi 3484 2 patients patient NNS cord-335975-m6lkrehi 3484 3 with with IN cord-335975-m6lkrehi 3484 4 acute acute JJ cord-335975-m6lkrehi 3484 5 circulatory circulatory JJ cord-335975-m6lkrehi 3484 6 respiratory respiratory JJ cord-335975-m6lkrehi 3484 7 failure failure NN cord-335975-m6lkrehi 3484 8 underwent undergo VBD cord-335975-m6lkrehi 3484 9 two two CD cord-335975-m6lkrehi 3484 10 basic basic JJ cord-335975-m6lkrehi 3484 11 TTE TTE NNP cord-335975-m6lkrehi 3484 12 assessments assessment NNS cord-335975-m6lkrehi 3484 13 using use VBG cord-335975-m6lkrehi 3484 14 successively successively RB cord-335975-m6lkrehi 3484 15 a a DT cord-335975-m6lkrehi 3484 16 next next JJ cord-335975-m6lkrehi 3484 17 - - HYPH cord-335975-m6lkrehi 3484 18 generation generation NN cord-335975-m6lkrehi 3484 19 micro micro JJ cord-335975-m6lkrehi 3484 20 - - JJ cord-335975-m6lkrehi 3484 21 digital digital JJ cord-335975-m6lkrehi 3484 22 broadband broadband NN cord-335975-m6lkrehi 3484 23 beamformer beamformer NN cord-335975-m6lkrehi 3484 24 ( ( -LRB- cord-335975-m6lkrehi 3484 25 64 64 CD cord-335975-m6lkrehi 3484 26 elements element NNS cord-335975-m6lkrehi 3484 27 , , , cord-335975-m6lkrehi 3484 28 1 1 CD cord-335975-m6lkrehi 3484 29 - - SYM cord-335975-m6lkrehi 3484 30 4 4 CD cord-335975-m6lkrehi 3484 31 MHz MHz NNPS cord-335975-m6lkrehi 3484 32 ) ) -RRB- cord-335975-m6lkrehi 3484 33 incorporated incorporate VBN cord-335975-m6lkrehi 3484 34 in in IN cord-335975-m6lkrehi 3484 35 a a DT cord-335975-m6lkrehi 3484 36 sector sector NN cord-335975-m6lkrehi 3484 37 phased phase VBN cord-335975-m6lkrehi 3484 38 array array NN cord-335975-m6lkrehi 3484 39 probe probe NN cord-335975-m6lkrehi 3484 40 with with IN cord-335975-m6lkrehi 3484 41 twodimensional twodimensional NNP cord-335975-m6lkrehi 3484 42 , , , cord-335975-m6lkrehi 3484 43 M M NNP cord-335975-m6lkrehi 3484 44 - - HYPH cord-335975-m6lkrehi 3484 45 mode mode NN cord-335975-m6lkrehi 3484 46 and and CC cord-335975-m6lkrehi 3484 47 color color NN cord-335975-m6lkrehi 3484 48 Doppler doppler NN cord-335975-m6lkrehi 3484 49 mapping mapping NN cord-335975-m6lkrehi 3484 50 capacities capacity NNS cord-335975-m6lkrehi 3484 51 which which WDT cord-335975-m6lkrehi 3484 52 was be VBD cord-335975-m6lkrehi 3484 53 connected connect VBN cord-335975-m6lkrehi 3484 54 to to IN cord-335975-m6lkrehi 3484 55 a a DT cord-335975-m6lkrehi 3484 56 touchscreen touchscreen NN cord-335975-m6lkrehi 3484 57 interface interface NN cord-335975-m6lkrehi 3484 58 ( ( -LRB- cord-335975-m6lkrehi 3484 59 Lumify Lumify NNP cord-335975-m6lkrehi 3484 60 , , , cord-335975-m6lkrehi 3484 61 Philips Philips NNP cord-335975-m6lkrehi 3484 62 ) ) -RRB- cord-335975-m6lkrehi 3484 63 , , , cord-335975-m6lkrehi 3484 64 and and CC cord-335975-m6lkrehi 3484 65 using use VBG cord-335975-m6lkrehi 3484 66 a a DT cord-335975-m6lkrehi 3484 67 compact compact JJ cord-335975-m6lkrehi 3484 68 full full JJ cord-335975-m6lkrehi 3484 69 - - HYPH cord-335975-m6lkrehi 3484 70 feature feature NN cord-335975-m6lkrehi 3484 71 imaging imaging NN cord-335975-m6lkrehi 3484 72 system system NN cord-335975-m6lkrehi 3484 73 ( ( -LRB- cord-335975-m6lkrehi 3484 74 80 80 CD cord-335975-m6lkrehi 3484 75 elements element NNS cord-335975-m6lkrehi 3484 76 , , , cord-335975-m6lkrehi 3484 77 1 1 CD cord-335975-m6lkrehi 3484 78 - - SYM cord-335975-m6lkrehi 3484 79 5 5 CD cord-335975-m6lkrehi 3484 80 MHz MHz NNPS cord-335975-m6lkrehi 3484 81 + + CC cord-335975-m6lkrehi 3484 82 Cx50 Cx50 NNPS cord-335975-m6lkrehi 3484 83 , , , cord-335975-m6lkrehi 3484 84 Philips Philips NNP cord-335975-m6lkrehi 3484 85 ) ) -RRB- cord-335975-m6lkrehi 3484 86 . . . cord-335975-m6lkrehi 3485 1 TTE TTE NNP cord-335975-m6lkrehi 3485 2 examinations examination NNS cord-335975-m6lkrehi 3485 3 were be VBD cord-335975-m6lkrehi 3485 4 independently independently RB cord-335975-m6lkrehi 3485 5 performed perform VBN cord-335975-m6lkrehi 3485 6 in in IN cord-335975-m6lkrehi 3485 7 random random JJ cord-335975-m6lkrehi 3485 8 order order NN cord-335975-m6lkrehi 3485 9 by by IN cord-335975-m6lkrehi 3485 10 two two CD cord-335975-m6lkrehi 3485 11 intensivists intensivist NNS cord-335975-m6lkrehi 3485 12 with with IN cord-335975-m6lkrehi 3485 13 expertise expertise NN cord-335975-m6lkrehi 3485 14 in in IN cord-335975-m6lkrehi 3485 15 CCE CCE NNP cord-335975-m6lkrehi 3485 16 , , , cord-335975-m6lkrehi 3485 17 within within IN cord-335975-m6lkrehi 3485 18 a a DT cord-335975-m6lkrehi 3485 19 10-min 10-min CD cord-335975-m6lkrehi 3485 20 time time NN cord-335975-m6lkrehi 3485 21 frame frame NN cord-335975-m6lkrehi 3485 22 without without IN cord-335975-m6lkrehi 3485 23 therapeutic therapeutic JJ cord-335975-m6lkrehi 3485 24 intervention intervention NN cord-335975-m6lkrehi 3485 25 . . . cord-335975-m6lkrehi 3486 1 Imaging imaging NN cord-335975-m6lkrehi 3486 2 quality quality NN cord-335975-m6lkrehi 3486 3 was be VBD cord-335975-m6lkrehi 3486 4 graded grade VBN cord-335975-m6lkrehi 3486 5 from from IN cord-335975-m6lkrehi 3486 6 0 0 NFP cord-335975-m6lkrehi 3486 7 ( ( -LRB- cord-335975-m6lkrehi 3486 8 no no DT cord-335975-m6lkrehi 3486 9 image image NN cord-335975-m6lkrehi 3486 10 in in IN cord-335975-m6lkrehi 3486 11 the the DT cord-335975-m6lkrehi 3486 12 corresponding corresponding JJ cord-335975-m6lkrehi 3486 13 view view NN cord-335975-m6lkrehi 3486 14 ) ) -RRB- cord-335975-m6lkrehi 3486 15 to to IN cord-335975-m6lkrehi 3486 16 3 3 LS cord-335975-m6lkrehi 3486 17 ( ( -LRB- cord-335975-m6lkrehi 3486 18 clear clear JJ cord-335975-m6lkrehi 3486 19 identification identification NN cord-335975-m6lkrehi 3486 20 of of IN cord-335975-m6lkrehi 3486 21 100 100 CD cord-335975-m6lkrehi 3486 22 % % NN cord-335975-m6lkrehi 3486 23 of of IN cord-335975-m6lkrehi 3486 24 endocardial endocardial NNP cord-335975-m6lkrehi 3486 25 boarders boarder NNS cord-335975-m6lkrehi 3486 26 ) ) -RRB- cord-335975-m6lkrehi 3486 27 . . . cord-335975-m6lkrehi 3487 1 The the DT cord-335975-m6lkrehi 3487 2 concordance concordance NN cord-335975-m6lkrehi 3487 3 of of IN cord-335975-m6lkrehi 3487 4 qualitative qualitative JJ cord-335975-m6lkrehi 3487 5 data datum NNS cord-335975-m6lkrehi 3487 6 was be VBD cord-335975-m6lkrehi 3487 7 assessed assess VBN cord-335975-m6lkrehi 3487 8 using use VBG cord-335975-m6lkrehi 3487 9 the the DT cord-335975-m6lkrehi 3487 10 Kappa Kappa NNP cord-335975-m6lkrehi 3487 11 test test NN cord-335975-m6lkrehi 3487 12 and and CC cord-335975-m6lkrehi 3487 13 agreement agreement NN cord-335975-m6lkrehi 3487 14 of of IN cord-335975-m6lkrehi 3487 15 two two CD cord-335975-m6lkrehi 3487 16 - - HYPH cord-335975-m6lkrehi 3487 17 dimensional dimensional JJ cord-335975-m6lkrehi 3487 18 measurements measurement NNS cord-335975-m6lkrehi 3487 19 ( ( -LRB- cord-335975-m6lkrehi 3487 20 left leave VBN cord-335975-m6lkrehi 3487 21 ventricular ventricular JJ cord-335975-m6lkrehi 3487 22 end end NN cord-335975-m6lkrehi 3487 23 - - HYPH cord-335975-m6lkrehi 3487 24 diastolic diastolic JJ cord-335975-m6lkrehi 3487 25 diameter diameter NN cord-335975-m6lkrehi 3487 26 [ [ -LRB- cord-335975-m6lkrehi 3487 27 LVEDD LVEDD NNP cord-335975-m6lkrehi 3487 28 ] ] -RRB- cord-335975-m6lkrehi 3487 29 , , , cord-335975-m6lkrehi 3487 30 ratio ratio NN cord-335975-m6lkrehi 3487 31 of of IN cord-335975-m6lkrehi 3487 32 right right JJ cord-335975-m6lkrehi 3487 33 ventricular ventricular NN cord-335975-m6lkrehi 3487 34 ( ( -LRB- cord-335975-m6lkrehi 3487 35 RV rv NN cord-335975-m6lkrehi 3487 36 ) ) -RRB- cord-335975-m6lkrehi 3487 37 and and CC cord-335975-m6lkrehi 3487 38 LV LV NNP cord-335975-m6lkrehi 3487 39 end end NN cord-335975-m6lkrehi 3487 40 - - HYPH cord-335975-m6lkrehi 3487 41 diastolic diastolic JJ cord-335975-m6lkrehi 3487 42 diameters diameter NNS cord-335975-m6lkrehi 3487 43 [ [ -LRB- cord-335975-m6lkrehi 3487 44 RVEDD RVEDD NNP cord-335975-m6lkrehi 3487 45 LVEDD LVEDD NNP cord-335975-m6lkrehi 3487 46 ] ] -RRB- cord-335975-m6lkrehi 3488 1 + + CC cord-335975-m6lkrehi 3488 2 end end NN cord-335975-m6lkrehi 3488 3 - - HYPH cord-335975-m6lkrehi 3488 4 expiratory expiratory JJ cord-335975-m6lkrehi 3488 5 inferior inferior JJ cord-335975-m6lkrehi 3488 6 vena vena FW cord-335975-m6lkrehi 3488 7 cava cava NN cord-335975-m6lkrehi 3488 8 diameter diameter NN cord-335975-m6lkrehi 3488 9 [ [ -LRB- cord-335975-m6lkrehi 3488 10 DexpIVC dexpivc NN cord-335975-m6lkrehi 3488 11 ] ] -RRB- cord-335975-m6lkrehi 3488 12 ) ) -RRB- cord-335975-m6lkrehi 3488 13 was be VBD cord-335975-m6lkrehi 3488 14 evaluated evaluate VBN cord-335975-m6lkrehi 3488 15 using use VBG cord-335975-m6lkrehi 3488 16 intraclass intraclass NN cord-335975-m6lkrehi 3488 17 coefficient coefficient NN cord-335975-m6lkrehi 3488 18 correlation correlation NN cord-335975-m6lkrehi 3488 19 ( ( -LRB- cord-335975-m6lkrehi 3488 20 ICC ICC NNP cord-335975-m6lkrehi 3488 21 ) ) -RRB- cord-335975-m6lkrehi 3488 22 . . . cord-335975-m6lkrehi 3489 1 Results result NNS cord-335975-m6lkrehi 3489 2 : : : cord-335975-m6lkrehi 3490 1 Thirty thirty CD cord-335975-m6lkrehi 3490 2 consecutive consecutive JJ cord-335975-m6lkrehi 3490 3 patients patient NNS cord-335975-m6lkrehi 3490 4 were be VBD cord-335975-m6lkrehi 3490 5 studied study VBN cord-335975-m6lkrehi 3490 6 , , , cord-335975-m6lkrehi 3490 7 without without IN cord-335975-m6lkrehi 3490 8 any any DT cord-335975-m6lkrehi 3490 9 exclusion exclusion NN cord-335975-m6lkrehi 3490 10 for for IN cord-335975-m6lkrehi 3490 11 absence absence NN cord-335975-m6lkrehi 3490 12 of of IN cord-335975-m6lkrehi 3490 13 TTE TTE NNP cord-335975-m6lkrehi 3490 14 images image NNS cord-335975-m6lkrehi 3490 15 ( ( -LRB- cord-335975-m6lkrehi 3490 16 age age NN cord-335975-m6lkrehi 3490 17 , , , cord-335975-m6lkrehi 3490 18 56 56 CD cord-335975-m6lkrehi 3490 19 ± ± CD cord-335975-m6lkrehi 3490 20 19 19 CD cord-335975-m6lkrehi 3490 21 years year NNS cord-335975-m6lkrehi 3490 22 , , , cord-335975-m6lkrehi 3490 23 SAP SAP NNP cord-335975-m6lkrehi 3490 24 - - HYPH cord-335975-m6lkrehi 3490 25 SII SII NNP cord-335975-m6lkrehi 3490 26 , , , cord-335975-m6lkrehi 3490 27 45 45 CD cord-335975-m6lkrehi 3490 28 ± ± NNP cord-335975-m6lkrehi 3490 29 18 18 CD cord-335975-m6lkrehi 3490 30 , , , cord-335975-m6lkrehi 3490 31 70 70 CD cord-335975-m6lkrehi 3490 32 % % NN cord-335975-m6lkrehi 3490 33 ventilated ventilate VBN cord-335975-m6lkrehi 3490 34 , , , cord-335975-m6lkrehi 3490 35 60 60 CD cord-335975-m6lkrehi 3490 36 % % NN cord-335975-m6lkrehi 3490 37 under under IN cord-335975-m6lkrehi 3490 38 catecholamines catecholamine NNS cord-335975-m6lkrehi 3490 39 , , , cord-335975-m6lkrehi 3490 40 lactate lactate NN cord-335975-m6lkrehi 3490 41 , , , cord-335975-m6lkrehi 3490 42 3.9 3.9 CD cord-335975-m6lkrehi 3490 43 ± ± CD cord-335975-m6lkrehi 3490 44 3.3 3.3 CD cord-335975-m6lkrehi 3490 45 mmol mmol JJ cord-335975-m6lkrehi 3490 46 l l NN cord-335975-m6lkrehi 3490 47 ) ) -RRB- cord-335975-m6lkrehi 3490 48 . . . cord-335975-m6lkrehi 3491 1 The the DT cord-335975-m6lkrehi 3491 2 proportion proportion NN cord-335975-m6lkrehi 3491 3 of of IN cord-335975-m6lkrehi 3491 4 echocardiographic echocardiographic JJ cord-335975-m6lkrehi 3491 5 views view NNS cord-335975-m6lkrehi 3491 6 eligible eligible JJ cord-335975-m6lkrehi 3491 7 for for IN cord-335975-m6lkrehi 3491 8 interpretation interpretation NN cord-335975-m6lkrehi 3491 9 and and CC cord-335975-m6lkrehi 3491 10 mean mean JJ cord-335975-m6lkrehi 3491 11 duration duration NN cord-335975-m6lkrehi 3491 12 of of IN cord-335975-m6lkrehi 3491 13 TTE TTE NNP cord-335975-m6lkrehi 3491 14 examinations examination NNS cord-335975-m6lkrehi 3491 15 were be VBD cord-335975-m6lkrehi 3491 16 similar similar JJ cord-335975-m6lkrehi 3491 17 with with IN cord-335975-m6lkrehi 3491 18 the the DT cord-335975-m6lkrehi 3491 19 miniaturized miniaturized JJ cord-335975-m6lkrehi 3491 20 and and CC cord-335975-m6lkrehi 3491 21 full full JJ cord-335975-m6lkrehi 3491 22 - - HYPH cord-335975-m6lkrehi 3491 23 feature feature NN cord-335975-m6lkrehi 3491 24 systems system NNS cord-335975-m6lkrehi 3491 25 ( ( -LRB- cord-335975-m6lkrehi 3491 26 79 79 CD cord-335975-m6lkrehi 3491 27 vs. vs. IN cord-335975-m6lkrehi 3491 28 77 77 CD cord-335975-m6lkrehi 3491 29 % % NN cord-335975-m6lkrehi 3491 30 , , , cord-335975-m6lkrehi 3491 31 7.1 7.1 CD cord-335975-m6lkrehi 3491 32 ± ± CD cord-335975-m6lkrehi 3491 33 2.7 2.7 CD cord-335975-m6lkrehi 3491 34 vs. vs. NN cord-335975-m6lkrehi 3491 35 7.9 7.9 CD cord-335975-m6lkrehi 3491 36 ± ± CD cord-335975-m6lkrehi 3491 37 4.1 4.1 CD cord-335975-m6lkrehi 3491 38 min min NN cord-335975-m6lkrehi 3491 39 , , , cord-335975-m6lkrehi 3491 40 p p NN cord-335975-m6lkrehi 3491 41 = = SYM cord-335975-m6lkrehi 3491 42 0.31 0.31 CD cord-335975-m6lkrehi 3491 43 ) ) -RRB- cord-335975-m6lkrehi 3491 44 . . . cord-335975-m6lkrehi 3492 1 Two two CD cord-335975-m6lkrehi 3492 2 - - HYPH cord-335975-m6lkrehi 3492 3 dimensional dimensional JJ cord-335975-m6lkrehi 3492 4 imaging imaging NN cord-335975-m6lkrehi 3492 5 quality quality NN cord-335975-m6lkrehi 3492 6 grade grade NN cord-335975-m6lkrehi 3492 7 was be VBD cord-335975-m6lkrehi 3492 8 lower low JJR cord-335975-m6lkrehi 3492 9 with with IN cord-335975-m6lkrehi 3492 10 the the DT cord-335975-m6lkrehi 3492 11 miniaturized miniaturized JJ cord-335975-m6lkrehi 3492 12 system system NN cord-335975-m6lkrehi 3492 13 ( ( -LRB- cord-335975-m6lkrehi 3492 14 system system NN cord-335975-m6lkrehi 3492 15 . . . cord-335975-m6lkrehi 3493 1 Concordance concordance NN cord-335975-m6lkrehi 3493 2 of of IN cord-335975-m6lkrehi 3493 3 two two CD cord-335975-m6lkrehi 3493 4 - - HYPH cord-335975-m6lkrehi 3493 5 dimensional dimensional JJ cord-335975-m6lkrehi 3493 6 measurements measurement NNS cord-335975-m6lkrehi 3493 7 was be VBD cord-335975-m6lkrehi 3493 8 also also RB cord-335975-m6lkrehi 3493 9 good good JJ cord-335975-m6lkrehi 3493 10 - - HYPH cord-335975-m6lkrehi 3493 11 to to IN cord-335975-m6lkrehi 3493 12 - - HYPH cord-335975-m6lkrehi 3493 13 excellent excellent JJ cord-335975-m6lkrehi 3493 14 ( ( -LRB- cord-335975-m6lkrehi 3493 15 Table table NN cord-335975-m6lkrehi 3493 16 1 1 CD cord-335975-m6lkrehi 3493 17 ) ) -RRB- cord-335975-m6lkrehi 3493 18 . . . cord-335975-m6lkrehi 3494 1 Conclusion conclusion NN cord-335975-m6lkrehi 3494 2 : : : cord-335975-m6lkrehi 3494 3 For for IN cord-335975-m6lkrehi 3494 4 basic basic JJ cord-335975-m6lkrehi 3494 5 CCE CCE NNP cord-335975-m6lkrehi 3494 6 use use NN cord-335975-m6lkrehi 3494 7 , , , cord-335975-m6lkrehi 3494 8 next next JJ cord-335975-m6lkrehi 3494 9 - - HYPH cord-335975-m6lkrehi 3494 10 generation generation NN cord-335975-m6lkrehi 3494 11 micro micro JJ cord-335975-m6lkrehi 3494 12 - - JJ cord-335975-m6lkrehi 3494 13 digital digital JJ cord-335975-m6lkrehi 3494 14 broadband broadband NN cord-335975-m6lkrehi 3494 15 beamformer beamformer NN cord-335975-m6lkrehi 3494 16 appears appear VBZ cord-335975-m6lkrehi 3494 17 providing provide VBG cord-335975-m6lkrehi 3494 18 reliable reliable JJ cord-335975-m6lkrehi 3494 19 information information NN cord-335975-m6lkrehi 3494 20 with with IN cord-335975-m6lkrehi 3494 21 good good JJ cord-335975-m6lkrehi 3494 22 - - HYPH cord-335975-m6lkrehi 3494 23 to to IN cord-335975-m6lkrehi 3494 24 - - HYPH cord-335975-m6lkrehi 3494 25 excellent excellent JJ cord-335975-m6lkrehi 3494 26 diagnostic diagnostic JJ cord-335975-m6lkrehi 3494 27 capability capability NN cord-335975-m6lkrehi 3494 28 , , , cord-335975-m6lkrehi 3494 29 accurate accurate JJ cord-335975-m6lkrehi 3494 30 two two CD cord-335975-m6lkrehi 3494 31 - - HYPH cord-335975-m6lkrehi 3494 32 dimensional dimensional JJ cord-335975-m6lkrehi 3494 33 measurements measurement NNS cord-335975-m6lkrehi 3494 34 , , , cord-335975-m6lkrehi 3494 35 and and CC cord-335975-m6lkrehi 3494 36 adapted adapt VBN cord-335975-m6lkrehi 3494 37 therapeutic therapeutic JJ cord-335975-m6lkrehi 3494 38 suggestions suggestion NNS cord-335975-m6lkrehi 3494 39 . . . cord-335975-m6lkrehi 3495 1 These these DT cord-335975-m6lkrehi 3495 2 preliminary preliminary JJ cord-335975-m6lkrehi 3495 3 data datum NNS cord-335975-m6lkrehi 3495 4 require require VBP cord-335975-m6lkrehi 3495 5 further further JJ cord-335975-m6lkrehi 3495 6 confirmation confirmation NN cord-335975-m6lkrehi 3495 7 . . . cord-335975-m6lkrehi 3496 1 Introduction introduction NN cord-335975-m6lkrehi 3496 2 : : : cord-335975-m6lkrehi 3497 1 Acute acute JJ cord-335975-m6lkrehi 3497 2 kidney kidney NN cord-335975-m6lkrehi 3497 3 injury injury NN cord-335975-m6lkrehi 3497 4 ( ( -LRB- cord-335975-m6lkrehi 3497 5 AKI AKI NNP cord-335975-m6lkrehi 3497 6 ) ) -RRB- cord-335975-m6lkrehi 3497 7 in in IN cord-335975-m6lkrehi 3497 8 very very RB cord-335975-m6lkrehi 3497 9 old old JJ cord-335975-m6lkrehi 3497 10 patients patient NNS cord-335975-m6lkrehi 3497 11 ( ( -LRB- cord-335975-m6lkrehi 3497 12 over over IN cord-335975-m6lkrehi 3497 13 80 80 CD cord-335975-m6lkrehi 3497 14 years year NNS cord-335975-m6lkrehi 3497 15 ) ) -RRB- cord-335975-m6lkrehi 3497 16 admitted admit VBN cord-335975-m6lkrehi 3497 17 in in IN cord-335975-m6lkrehi 3497 18 intensive intensive JJ cord-335975-m6lkrehi 3497 19 care care NN cord-335975-m6lkrehi 3497 20 unit unit NN cord-335975-m6lkrehi 3497 21 ( ( -LRB- cord-335975-m6lkrehi 3497 22 ICU ICU NNP cord-335975-m6lkrehi 3497 23 ) ) -RRB- cord-335975-m6lkrehi 3497 24 is be VBZ cord-335975-m6lkrehi 3497 25 a a DT cord-335975-m6lkrehi 3497 26 frequent frequent JJ cord-335975-m6lkrehi 3497 27 issue issue NN cord-335975-m6lkrehi 3497 28 and and CC cord-335975-m6lkrehi 3497 29 is be VBZ cord-335975-m6lkrehi 3497 30 known know VBN cord-335975-m6lkrehi 3497 31 to to TO cord-335975-m6lkrehi 3497 32 be be VB cord-335975-m6lkrehi 3497 33 associated associate VBN cord-335975-m6lkrehi 3497 34 with with IN cord-335975-m6lkrehi 3497 35 a a DT cord-335975-m6lkrehi 3497 36 severe severe JJ cord-335975-m6lkrehi 3497 37 prognosis prognosis NN cord-335975-m6lkrehi 3497 38 . . . cord-335975-m6lkrehi 3498 1 We -PRON- PRP cord-335975-m6lkrehi 3498 2 aimed aim VBD cord-335975-m6lkrehi 3498 3 at at IN cord-335975-m6lkrehi 3498 4 describing describe VBG cord-335975-m6lkrehi 3498 5 the the DT cord-335975-m6lkrehi 3498 6 clinical clinical JJ cord-335975-m6lkrehi 3498 7 characteristics characteristic NNS cord-335975-m6lkrehi 3498 8 and and CC cord-335975-m6lkrehi 3498 9 prognosis prognosis NN cord-335975-m6lkrehi 3498 10 of of IN cord-335975-m6lkrehi 3498 11 such such PDT cord-335975-m6lkrehi 3498 12 a a DT cord-335975-m6lkrehi 3498 13 population population NN cord-335975-m6lkrehi 3498 14 . . . cord-335975-m6lkrehi 3499 1 The the DT cord-335975-m6lkrehi 3499 2 objective objective NN cord-335975-m6lkrehi 3499 3 of of IN cord-335975-m6lkrehi 3499 4 the the DT cord-335975-m6lkrehi 3499 5 study study NN cord-335975-m6lkrehi 3499 6 was be VBD cord-335975-m6lkrehi 3499 7 dual dual JJ cord-335975-m6lkrehi 3499 8 : : : cord-335975-m6lkrehi 3499 9 first first RB cord-335975-m6lkrehi 3499 10 to to TO cord-335975-m6lkrehi 3499 11 evaluate evaluate VB cord-335975-m6lkrehi 3499 12 the the DT cord-335975-m6lkrehi 3499 13 short short JJ cord-335975-m6lkrehi 3499 14 and and CC cord-335975-m6lkrehi 3499 15 long long JJ cord-335975-m6lkrehi 3499 16 term term NN cord-335975-m6lkrehi 3499 17 mortality mortality NN cord-335975-m6lkrehi 3499 18 of of IN cord-335975-m6lkrehi 3499 19 these these DT cord-335975-m6lkrehi 3499 20 patients patient NNS cord-335975-m6lkrehi 3499 21 , , , cord-335975-m6lkrehi 3499 22 second second JJ cord-335975-m6lkrehi 3499 23 to to TO cord-335975-m6lkrehi 3499 24 determine determine VB cord-335975-m6lkrehi 3499 25 the the DT cord-335975-m6lkrehi 3499 26 factors factor NNS cord-335975-m6lkrehi 3499 27 associated associate VBN cord-335975-m6lkrehi 3499 28 with with IN cord-335975-m6lkrehi 3499 29 a a DT cord-335975-m6lkrehi 3499 30 poor poor JJ cord-335975-m6lkrehi 3499 31 outcome outcome NN cord-335975-m6lkrehi 3499 32 . . . cord-335975-m6lkrehi 3500 1 Patients patient NNS cord-335975-m6lkrehi 3500 2 and and CC cord-335975-m6lkrehi 3500 3 methods method NNS cord-335975-m6lkrehi 3501 1 : : : cord-335975-m6lkrehi 3501 2 We -PRON- PRP cord-335975-m6lkrehi 3501 3 conducted conduct VBD cord-335975-m6lkrehi 3501 4 a a DT cord-335975-m6lkrehi 3501 5 descriptive descriptive JJ cord-335975-m6lkrehi 3501 6 , , , cord-335975-m6lkrehi 3501 7 retrospective retrospective JJ cord-335975-m6lkrehi 3501 8 and and CC cord-335975-m6lkrehi 3501 9 monocentric monocentric JJ cord-335975-m6lkrehi 3501 10 study study NN cord-335975-m6lkrehi 3501 11 based base VBN cord-335975-m6lkrehi 3501 12 on on IN cord-335975-m6lkrehi 3501 13 the the DT cord-335975-m6lkrehi 3501 14 hospital hospital NN cord-335975-m6lkrehi 3501 15 records record NNS cord-335975-m6lkrehi 3501 16 of of IN cord-335975-m6lkrehi 3501 17 patients patient NNS cord-335975-m6lkrehi 3501 18 over over IN cord-335975-m6lkrehi 3501 19 80 80 CD cord-335975-m6lkrehi 3501 20 years year NNS cord-335975-m6lkrehi 3501 21 with with IN cord-335975-m6lkrehi 3501 22 AKI AKI NNP cord-335975-m6lkrehi 3501 23 admitted admit VBD cord-335975-m6lkrehi 3501 24 in in IN cord-335975-m6lkrehi 3501 25 our -PRON- PRP$ cord-335975-m6lkrehi 3501 26 ICU ICU NNP cord-335975-m6lkrehi 3501 27 between between IN cord-335975-m6lkrehi 3501 28 January January NNP cord-335975-m6lkrehi 3501 29 2013 2013 CD cord-335975-m6lkrehi 3501 30 and and CC cord-335975-m6lkrehi 3501 31 December December NNP cord-335975-m6lkrehi 3501 32 2016 2016 CD cord-335975-m6lkrehi 3501 33 . . . cord-335975-m6lkrehi 3502 1 The the DT cord-335975-m6lkrehi 3502 2 patients patient NNS cord-335975-m6lkrehi 3502 3 were be VBD cord-335975-m6lkrehi 3502 4 selected select VBN cord-335975-m6lkrehi 3502 5 according accord VBG cord-335975-m6lkrehi 3502 6 to to IN cord-335975-m6lkrehi 3502 7 the the DT cord-335975-m6lkrehi 3502 8 KDIGO KDIGO NNP cord-335975-m6lkrehi 3502 9 criteria criterion NNS cord-335975-m6lkrehi 3502 10 ( ( -LRB- cord-335975-m6lkrehi 3502 11 1 1 CD cord-335975-m6lkrehi 3502 12 ) ) -RRB- cord-335975-m6lkrehi 3502 13 . . . cord-335975-m6lkrehi 3503 1 Survivals survival NNS cord-335975-m6lkrehi 3503 2 at at IN cord-335975-m6lkrehi 3503 3 the the DT cord-335975-m6lkrehi 3503 4 discharge discharge NN cord-335975-m6lkrehi 3503 5 from from IN cord-335975-m6lkrehi 3503 6 hospital hospital NN cord-335975-m6lkrehi 3503 7 , , , cord-335975-m6lkrehi 3503 8 at at IN cord-335975-m6lkrehi 3503 9 day day NN cord-335975-m6lkrehi 3503 10 90 90 CD cord-335975-m6lkrehi 3503 11 and and CC cord-335975-m6lkrehi 3503 12 at at IN cord-335975-m6lkrehi 3503 13 1 1 CD cord-335975-m6lkrehi 3503 14 year year NN cord-335975-m6lkrehi 3503 15 were be VBD cord-335975-m6lkrehi 3503 16 assessed assess VBN cord-335975-m6lkrehi 3503 17 . . . cord-335975-m6lkrehi 3504 1 The the DT cord-335975-m6lkrehi 3504 2 factors factor NNS cord-335975-m6lkrehi 3504 3 associated associate VBN cord-335975-m6lkrehi 3504 4 with with IN cord-335975-m6lkrehi 3504 5 mortality mortality NN cord-335975-m6lkrehi 3504 6 at at IN cord-335975-m6lkrehi 3504 7 1 1 CD cord-335975-m6lkrehi 3504 8 year year NN cord-335975-m6lkrehi 3504 9 were be VBD cord-335975-m6lkrehi 3504 10 scrutinized scrutinize VBN cord-335975-m6lkrehi 3504 11 . . . cord-335975-m6lkrehi 3505 1 Results result NNS cord-335975-m6lkrehi 3505 2 : : : cord-335975-m6lkrehi 3506 1 After after IN cord-335975-m6lkrehi 3506 2 excluding exclude VBG cord-335975-m6lkrehi 3506 3 30 30 CD cord-335975-m6lkrehi 3506 4 patients patient NNS cord-335975-m6lkrehi 3506 5 for for IN cord-335975-m6lkrehi 3506 6 an an DT cord-335975-m6lkrehi 3506 7 initial initial JJ cord-335975-m6lkrehi 3506 8 therapeutic therapeutic JJ cord-335975-m6lkrehi 3506 9 limitation limitation NN cord-335975-m6lkrehi 3506 10 , , , cord-335975-m6lkrehi 3506 11 the the DT cord-335975-m6lkrehi 3506 12 data datum NNS cord-335975-m6lkrehi 3506 13 of of IN cord-335975-m6lkrehi 3506 14 171 171 CD cord-335975-m6lkrehi 3506 15 remaining remain VBG cord-335975-m6lkrehi 3506 16 patients patient NNS cord-335975-m6lkrehi 3506 17 were be VBD cord-335975-m6lkrehi 3506 18 reviewed review VBN cord-335975-m6lkrehi 3506 19 . . . cord-335975-m6lkrehi 3507 1 The the DT cord-335975-m6lkrehi 3507 2 patients patient NNS cord-335975-m6lkrehi 3507 3 were be VBD cord-335975-m6lkrehi 3507 4 84 84 CD cord-335975-m6lkrehi 3507 5 years year NNS cord-335975-m6lkrehi 3507 6 old old JJ cord-335975-m6lkrehi 3507 7 ( ( -LRB- cord-335975-m6lkrehi 3507 8 interquartile interquartile JJ cord-335975-m6lkrehi 3507 9 range range NN cord-335975-m6lkrehi 3507 10 , , , cord-335975-m6lkrehi 3507 11 IQR IQR NNP cord-335975-m6lkrehi 3507 12 81 81 CD cord-335975-m6lkrehi 3507 13 - - SYM cord-335975-m6lkrehi 3507 14 86 86 CD cord-335975-m6lkrehi 3507 15 ) ) -RRB- cord-335975-m6lkrehi 3507 16 and and CC cord-335975-m6lkrehi 3507 17 were be VBD cord-335975-m6lkrehi 3507 18 predominantly predominantly RB cord-335975-m6lkrehi 3507 19 male male JJ cord-335975-m6lkrehi 3507 20 gender gender NN cord-335975-m6lkrehi 3507 21 ( ( -LRB- cord-335975-m6lkrehi 3507 22 61 61 CD cord-335975-m6lkrehi 3507 23 % % NN cord-335975-m6lkrehi 3507 24 ) ) -RRB- cord-335975-m6lkrehi 3507 25 . . . cord-335975-m6lkrehi 3508 1 SAPS SAPS NNP cord-335975-m6lkrehi 3508 2 II II NNP cord-335975-m6lkrehi 3508 3 and and CC cord-335975-m6lkrehi 3508 4 SOFA sofa NN cord-335975-m6lkrehi 3508 5 score score NN cord-335975-m6lkrehi 3508 6 at at IN cord-335975-m6lkrehi 3508 7 admission admission NN cord-335975-m6lkrehi 3508 8 were be VBD cord-335975-m6lkrehi 3508 9 62 62 CD cord-335975-m6lkrehi 3509 1 ( ( -LRB- cord-335975-m6lkrehi 3509 2 IQR IQR NNP cord-335975-m6lkrehi 3509 3 57 57 CD cord-335975-m6lkrehi 3509 4 - - SYM cord-335975-m6lkrehi 3509 5 74 74 CD cord-335975-m6lkrehi 3509 6 ) ) -RRB- cord-335975-m6lkrehi 3510 1 and and CC cord-335975-m6lkrehi 3510 2 8 8 CD cord-335975-m6lkrehi 3510 3 ( ( -LRB- cord-335975-m6lkrehi 3510 4 IQR IQR NNP cord-335975-m6lkrehi 3510 5 5 5 CD cord-335975-m6lkrehi 3510 6 - - SYM cord-335975-m6lkrehi 3510 7 10 10 CD cord-335975-m6lkrehi 3510 8 ) ) -RRB- cord-335975-m6lkrehi 3510 9 respectively respectively RB cord-335975-m6lkrehi 3510 10 . . . cord-335975-m6lkrehi 3511 1 57 57 CD cord-335975-m6lkrehi 3511 2 % % NN cord-335975-m6lkrehi 3511 3 of of IN cord-335975-m6lkrehi 3511 4 the the DT cord-335975-m6lkrehi 3511 5 patients patient NNS cord-335975-m6lkrehi 3511 6 needed need VBN cord-335975-m6lkrehi 3511 7 for for IN cord-335975-m6lkrehi 3511 8 mechanical mechanical JJ cord-335975-m6lkrehi 3511 9 ventilation ventilation NN cord-335975-m6lkrehi 3511 10 and and CC cord-335975-m6lkrehi 3511 11 69 69 CD cord-335975-m6lkrehi 3511 12 % % NN cord-335975-m6lkrehi 3511 13 of of IN cord-335975-m6lkrehi 3511 14 them -PRON- PRP cord-335975-m6lkrehi 3511 15 needed need VBD cord-335975-m6lkrehi 3511 16 for for IN cord-335975-m6lkrehi 3511 17 catecholamine catecholamine NN cord-335975-m6lkrehi 3511 18 use use NN cord-335975-m6lkrehi 3511 19 . . . cord-335975-m6lkrehi 3512 1 Septic Septic NNP cord-335975-m6lkrehi 3512 2 ( ( -LRB- cord-335975-m6lkrehi 3512 3 44 44 CD cord-335975-m6lkrehi 3512 4 % % NN cord-335975-m6lkrehi 3512 5 ) ) -RRB- cord-335975-m6lkrehi 3512 6 , , , cord-335975-m6lkrehi 3512 7 prerenal prerenal NNP cord-335975-m6lkrehi 3512 8 ( ( -LRB- cord-335975-m6lkrehi 3512 9 38 38 CD cord-335975-m6lkrehi 3512 10 % % NN cord-335975-m6lkrehi 3512 11 ) ) -RRB- cord-335975-m6lkrehi 3512 12 , , , cord-335975-m6lkrehi 3512 13 iatrogenic iatrogenic JJ cord-335975-m6lkrehi 3512 14 ( ( -LRB- cord-335975-m6lkrehi 3512 15 17 17 CD cord-335975-m6lkrehi 3512 16 % % NN cord-335975-m6lkrehi 3512 17 ) ) -RRB- cord-335975-m6lkrehi 3512 18 and and CC cord-335975-m6lkrehi 3512 19 cardiogenic cardiogenic JJ cord-335975-m6lkrehi 3512 20 injury injury NN cord-335975-m6lkrehi 3512 21 ( ( -LRB- cord-335975-m6lkrehi 3512 22 10 10 CD cord-335975-m6lkrehi 3512 23 % % NN cord-335975-m6lkrehi 3512 24 ) ) -RRB- cord-335975-m6lkrehi 3512 25 were be VBD cord-335975-m6lkrehi 3512 26 the the DT cord-335975-m6lkrehi 3512 27 leading leading JJ cord-335975-m6lkrehi 3512 28 cause cause NN cord-335975-m6lkrehi 3512 29 of of IN cord-335975-m6lkrehi 3512 30 AKI AKI NNP cord-335975-m6lkrehi 3512 31 . . . cord-335975-m6lkrehi 3513 1 Dialysis dialysis NN cord-335975-m6lkrehi 3513 2 was be VBD cord-335975-m6lkrehi 3513 3 performed perform VBN cord-335975-m6lkrehi 3513 4 in in IN cord-335975-m6lkrehi 3513 5 42 42 CD cord-335975-m6lkrehi 3513 6 % % NN cord-335975-m6lkrehi 3513 7 of of IN cord-335975-m6lkrehi 3513 8 patients patient NNS cord-335975-m6lkrehi 3513 9 . . . cord-335975-m6lkrehi 3514 1 The the DT cord-335975-m6lkrehi 3514 2 overall overall JJ cord-335975-m6lkrehi 3514 3 mortality mortality NN cord-335975-m6lkrehi 3514 4 at at IN cord-335975-m6lkrehi 3514 5 the the DT cord-335975-m6lkrehi 3514 6 discharge discharge NN cord-335975-m6lkrehi 3514 7 from from IN cord-335975-m6lkrehi 3514 8 ICU ICU NNP cord-335975-m6lkrehi 3514 9 , , , cord-335975-m6lkrehi 3514 10 at at IN cord-335975-m6lkrehi 3514 11 day day NN cord-335975-m6lkrehi 3514 12 90 90 CD cord-335975-m6lkrehi 3514 13 and and CC cord-335975-m6lkrehi 3514 14 at at IN cord-335975-m6lkrehi 3514 15 1 1 CD cord-335975-m6lkrehi 3514 16 year year NN cord-335975-m6lkrehi 3514 17 was be VBD cord-335975-m6lkrehi 3514 18 39 39 CD cord-335975-m6lkrehi 3514 19 , , , cord-335975-m6lkrehi 3514 20 52 52 CD cord-335975-m6lkrehi 3514 21 and and CC cord-335975-m6lkrehi 3514 22 66 66 CD cord-335975-m6lkrehi 3514 23 % % NN cord-335975-m6lkrehi 3514 24 respectively respectively RB cord-335975-m6lkrehi 3514 25 ( ( -LRB- cord-335975-m6lkrehi 3514 26 Fig fig NN cord-335975-m6lkrehi 3514 27 . . . cord-335975-m6lkrehi 3514 28 1 1 CD cord-335975-m6lkrehi 3514 29 ) ) -RRB- cord-335975-m6lkrehi 3514 30 . . . cord-335975-m6lkrehi 3515 1 Neither neither DT cord-335975-m6lkrehi 3515 2 were be VBD cord-335975-m6lkrehi 3515 3 the the DT cord-335975-m6lkrehi 3515 4 age age NN cord-335975-m6lkrehi 3515 5 , , , cord-335975-m6lkrehi 3515 6 the the DT cord-335975-m6lkrehi 3515 7 comorbidities comorbiditie NNS cord-335975-m6lkrehi 3515 8 , , , cord-335975-m6lkrehi 3515 9 the the DT cord-335975-m6lkrehi 3515 10 etiology etiology NN cord-335975-m6lkrehi 3515 11 of of IN cord-335975-m6lkrehi 3515 12 AKI AKI NNP cord-335975-m6lkrehi 3515 13 nor nor CC cord-335975-m6lkrehi 3515 14 the the DT cord-335975-m6lkrehi 3515 15 need need NN cord-335975-m6lkrehi 3515 16 for for IN cord-335975-m6lkrehi 3515 17 dialysis dialysis NN cord-335975-m6lkrehi 3515 18 associated associate VBN cord-335975-m6lkrehi 3515 19 to to IN cord-335975-m6lkrehi 3515 20 a a DT cord-335975-m6lkrehi 3515 21 significant significant JJ cord-335975-m6lkrehi 3515 22 increase increase NN cord-335975-m6lkrehi 3515 23 in in IN cord-335975-m6lkrehi 3515 24 mortality mortality NN cord-335975-m6lkrehi 3515 25 . . . cord-335975-m6lkrehi 3516 1 A a DT cord-335975-m6lkrehi 3516 2 stepwise stepwise JJ cord-335975-m6lkrehi 3516 3 Cox Cox NNP cord-335975-m6lkrehi 3516 4 regression regression NN cord-335975-m6lkrehi 3516 5 analysis analysis NN cord-335975-m6lkrehi 3516 6 revealed reveal VBD cord-335975-m6lkrehi 3516 7 SAPS SAPS NNP cord-335975-m6lkrehi 3516 8 II II NNP cord-335975-m6lkrehi 3516 9 and and CC cord-335975-m6lkrehi 3516 10 blood blood NN cord-335975-m6lkrehi 3516 11 lactate lactate NN cord-335975-m6lkrehi 3516 12 level level NN cord-335975-m6lkrehi 3516 13 at at IN cord-335975-m6lkrehi 3516 14 ICU ICU NNP cord-335975-m6lkrehi 3516 15 admission admission NN cord-335975-m6lkrehi 3516 16 as as IN cord-335975-m6lkrehi 3516 17 independent independent JJ cord-335975-m6lkrehi 3516 18 risk risk NN cord-335975-m6lkrehi 3516 19 factors factor NNS cord-335975-m6lkrehi 3516 20 associated associate VBN cord-335975-m6lkrehi 3516 21 with with IN cord-335975-m6lkrehi 3516 22 1 1 CD cord-335975-m6lkrehi 3516 23 year year NN cord-335975-m6lkrehi 3516 24 mortality mortality NN cord-335975-m6lkrehi 3516 25 . . . cord-335975-m6lkrehi 3517 1 Conclusion conclusion NN cord-335975-m6lkrehi 3517 2 : : : cord-335975-m6lkrehi 3517 3 AKI AKI NNP cord-335975-m6lkrehi 3517 4 at at IN cord-335975-m6lkrehi 3517 5 admission admission NN cord-335975-m6lkrehi 3517 6 in in IN cord-335975-m6lkrehi 3517 7 ICU ICU NNP cord-335975-m6lkrehi 3517 8 is be VBZ cord-335975-m6lkrehi 3517 9 associated associate VBN cord-335975-m6lkrehi 3517 10 with with IN cord-335975-m6lkrehi 3517 11 a a DT cord-335975-m6lkrehi 3517 12 high high JJ cord-335975-m6lkrehi 3517 13 mortality mortality NN cord-335975-m6lkrehi 3517 14 at at IN cord-335975-m6lkrehi 3517 15 1 1 CD cord-335975-m6lkrehi 3517 16 year year NN cord-335975-m6lkrehi 3517 17 in in IN cord-335975-m6lkrehi 3517 18 an an DT cord-335975-m6lkrehi 3517 19 elderly elderly JJ cord-335975-m6lkrehi 3517 20 population population NN cord-335975-m6lkrehi 3517 21 . . . cord-335975-m6lkrehi 3518 1 Main main JJ cord-335975-m6lkrehi 3518 2 long long JJ cord-335975-m6lkrehi 3518 3 term term NN cord-335975-m6lkrehi 3518 4 prognostic prognostic JJ cord-335975-m6lkrehi 3518 5 factors factor NNS cord-335975-m6lkrehi 3518 6 are be VBP cord-335975-m6lkrehi 3518 7 linked link VBN cord-335975-m6lkrehi 3518 8 to to IN cord-335975-m6lkrehi 3518 9 the the DT cord-335975-m6lkrehi 3518 10 initial initial JJ cord-335975-m6lkrehi 3518 11 severity severity NN cord-335975-m6lkrehi 3518 12 at at IN cord-335975-m6lkrehi 3518 13 ICU ICU NNP cord-335975-m6lkrehi 3518 14 admission admission NN cord-335975-m6lkrehi 3518 15 . . . cord-335975-m6lkrehi 3519 1 Introduction introduction NN cord-335975-m6lkrehi 3519 2 : : : cord-335975-m6lkrehi 3520 1 The the DT cord-335975-m6lkrehi 3520 2 proportion proportion NN cord-335975-m6lkrehi 3520 3 of of IN cord-335975-m6lkrehi 3520 4 elderly elderly JJ cord-335975-m6lkrehi 3520 5 around around IN cord-335975-m6lkrehi 3520 6 the the DT cord-335975-m6lkrehi 3520 7 world world NN cord-335975-m6lkrehi 3520 8 does do VBZ cord-335975-m6lkrehi 3520 9 n't not RB cord-335975-m6lkrehi 3520 10 stop stop VB cord-335975-m6lkrehi 3520 11 growing grow VBG cord-335975-m6lkrehi 3520 12 and and CC cord-335975-m6lkrehi 3520 13 increases increase VBZ cord-335975-m6lkrehi 3520 14 the the DT cord-335975-m6lkrehi 3520 15 consumption consumption NN cord-335975-m6lkrehi 3520 16 in in IN cord-335975-m6lkrehi 3520 17 health health NN cord-335975-m6lkrehi 3520 18 care care NN cord-335975-m6lkrehi 3520 19 . . . cord-335975-m6lkrehi 3521 1 However however RB cord-335975-m6lkrehi 3521 2 , , , cord-335975-m6lkrehi 3521 3 lots lot NNS cord-335975-m6lkrehi 3521 4 of of IN cord-335975-m6lkrehi 3521 5 studies study NNS cord-335975-m6lkrehi 3521 6 report report VBP cord-335975-m6lkrehi 3521 7 the the DT cord-335975-m6lkrehi 3521 8 impact impact NN cord-335975-m6lkrehi 3521 9 of of IN cord-335975-m6lkrehi 3521 10 the the DT cord-335975-m6lkrehi 3521 11 age age NN cord-335975-m6lkrehi 3521 12 on on IN cord-335975-m6lkrehi 3521 13 the the DT cord-335975-m6lkrehi 3521 14 decision decision NN cord-335975-m6lkrehi 3521 15 to to TO cord-335975-m6lkrehi 3521 16 admit admit VB cord-335975-m6lkrehi 3521 17 a a DT cord-335975-m6lkrehi 3521 18 patient patient NN cord-335975-m6lkrehi 3521 19 to to IN cord-335975-m6lkrehi 3521 20 the the DT cord-335975-m6lkrehi 3521 21 ICU ICU NNP cord-335975-m6lkrehi 3521 22 despite despite IN cord-335975-m6lkrehi 3521 23 no no DT cord-335975-m6lkrehi 3521 24 triage triage NN cord-335975-m6lkrehi 3521 25 recommendation recommendation NN cord-335975-m6lkrehi 3521 26 exists exist VBZ cord-335975-m6lkrehi 3521 27 . . . cord-335975-m6lkrehi 3522 1 The the DT cord-335975-m6lkrehi 3522 2 primary primary JJ cord-335975-m6lkrehi 3522 3 objective objective NN cord-335975-m6lkrehi 3522 4 was be VBD cord-335975-m6lkrehi 3522 5 to to TO cord-335975-m6lkrehi 3522 6 determine determine VB cord-335975-m6lkrehi 3522 7 prognostic prognostic JJ cord-335975-m6lkrehi 3522 8 factors factor NNS cord-335975-m6lkrehi 3522 9 of of IN cord-335975-m6lkrehi 3522 10 death death NN cord-335975-m6lkrehi 3522 11 for for IN cord-335975-m6lkrehi 3522 12 the the DT cord-335975-m6lkrehi 3522 13 80 80 CD cord-335975-m6lkrehi 3522 14 years year NNS cord-335975-m6lkrehi 3522 15 and and CC cord-335975-m6lkrehi 3522 16 over over RB cord-335975-m6lkrehi 3522 17 at at IN cord-335975-m6lkrehi 3522 18 admission admission NN cord-335975-m6lkrehi 3522 19 to to IN cord-335975-m6lkrehi 3522 20 the the DT cord-335975-m6lkrehi 3522 21 ICU ICU NNP cord-335975-m6lkrehi 3522 22 and and CC cord-335975-m6lkrehi 3522 23 secondly secondly RB cord-335975-m6lkrehi 3522 24 to to TO cord-335975-m6lkrehi 3522 25 evaluate evaluate VB cord-335975-m6lkrehi 3522 26 their -PRON- PRP$ cord-335975-m6lkrehi 3522 27 functional functional JJ cord-335975-m6lkrehi 3522 28 prognostic prognostic NN cord-335975-m6lkrehi 3522 29 at at IN cord-335975-m6lkrehi 3522 30 short short JJ cord-335975-m6lkrehi 3522 31 and and CC cord-335975-m6lkrehi 3522 32 medium medium JJ cord-335975-m6lkrehi 3522 33 term term NN cord-335975-m6lkrehi 3522 34 after after IN cord-335975-m6lkrehi 3522 35 their -PRON- PRP$ cord-335975-m6lkrehi 3522 36 exit exit NN cord-335975-m6lkrehi 3522 37 . . . cord-335975-m6lkrehi 3523 1 Patients patient NNS cord-335975-m6lkrehi 3523 2 and and CC cord-335975-m6lkrehi 3523 3 methods method NNS cord-335975-m6lkrehi 3523 4 : : : cord-335975-m6lkrehi 3523 5 Prospective prospective JJ cord-335975-m6lkrehi 3523 6 and and CC cord-335975-m6lkrehi 3523 7 observational observational JJ cord-335975-m6lkrehi 3523 8 study study NN cord-335975-m6lkrehi 3523 9 conducted conduct VBN cord-335975-m6lkrehi 3523 10 in in IN cord-335975-m6lkrehi 3523 11 our -PRON- PRP$ cord-335975-m6lkrehi 3523 12 ICU ICU NNP cord-335975-m6lkrehi 3523 13 30 30 CD cord-335975-m6lkrehi 3523 14 beds bed NNS cord-335975-m6lkrehi 3523 15 unit unit NN cord-335975-m6lkrehi 3523 16 from from IN cord-335975-m6lkrehi 3523 17 August August NNP cord-335975-m6lkrehi 3523 18 2015 2015 CD cord-335975-m6lkrehi 3523 19 to to IN cord-335975-m6lkrehi 3523 20 February February NNP cord-335975-m6lkrehi 3523 21 2017 2017 CD cord-335975-m6lkrehi 3523 22 . . . cord-335975-m6lkrehi 3524 1 Patients patient NNS cord-335975-m6lkrehi 3524 2 of of IN cord-335975-m6lkrehi 3524 3 80 80 CD cord-335975-m6lkrehi 3524 4 years year NNS cord-335975-m6lkrehi 3524 5 and and CC cord-335975-m6lkrehi 3524 6 over over RB cord-335975-m6lkrehi 3524 7 were be VBD cord-335975-m6lkrehi 3524 8 listed list VBN cord-335975-m6lkrehi 3524 9 . . . cord-335975-m6lkrehi 3525 1 The the DT cord-335975-m6lkrehi 3525 2 dying die VBG cord-335975-m6lkrehi 3525 3 patients patient NNS cord-335975-m6lkrehi 3525 4 arriving arrive VBG cord-335975-m6lkrehi 3525 5 after after IN cord-335975-m6lkrehi 3525 6 a a DT cord-335975-m6lkrehi 3525 7 pre pre JJ cord-335975-m6lkrehi 3525 8 - - JJ cord-335975-m6lkrehi 3525 9 hospital hospital JJ cord-335975-m6lkrehi 3525 10 resuscitation resuscitation NN cord-335975-m6lkrehi 3525 11 for for IN cord-335975-m6lkrehi 3525 12 whom whom WP cord-335975-m6lkrehi 3525 13 no no DT cord-335975-m6lkrehi 3525 14 therapeutic therapeutic JJ cord-335975-m6lkrehi 3525 15 plan plan NN cord-335975-m6lkrehi 3525 16 has have VBZ cord-335975-m6lkrehi 3525 17 been be VBN cord-335975-m6lkrehi 3525 18 initiated initiate VBN cord-335975-m6lkrehi 3525 19 and and CC cord-335975-m6lkrehi 3525 20 those those DT cord-335975-m6lkrehi 3525 21 admitted admit VBN cord-335975-m6lkrehi 3525 22 for for IN cord-335975-m6lkrehi 3525 23 an an DT cord-335975-m6lkrehi 3525 24 organ organ NN cord-335975-m6lkrehi 3525 25 donation donation NN cord-335975-m6lkrehi 3525 26 were be VBD cord-335975-m6lkrehi 3525 27 excluded exclude VBN cord-335975-m6lkrehi 3525 28 . . . cord-335975-m6lkrehi 3526 1 The the DT cord-335975-m6lkrehi 3526 2 primary primary JJ cord-335975-m6lkrehi 3526 3 outcome outcome NN cord-335975-m6lkrehi 3526 4 was be VBD cord-335975-m6lkrehi 3526 5 the the DT cord-335975-m6lkrehi 3526 6 duration duration NN cord-335975-m6lkrehi 3526 7 between between IN cord-335975-m6lkrehi 3526 8 the the DT cord-335975-m6lkrehi 3526 9 admission admission NN cord-335975-m6lkrehi 3526 10 and and CC cord-335975-m6lkrehi 3526 11 the the DT cord-335975-m6lkrehi 3526 12 potential potential JJ cord-335975-m6lkrehi 3526 13 death death NN cord-335975-m6lkrehi 3526 14 during during IN cord-335975-m6lkrehi 3526 15 the the DT cord-335975-m6lkrehi 3526 16 follow follow NN cord-335975-m6lkrehi 3526 17 - - HYPH cord-335975-m6lkrehi 3526 18 up up NN cord-335975-m6lkrehi 3526 19 . . . cord-335975-m6lkrehi 3527 1 The the DT cord-335975-m6lkrehi 3527 2 secondary secondary JJ cord-335975-m6lkrehi 3527 3 outcomes outcome NNS cord-335975-m6lkrehi 3527 4 were be VBD cord-335975-m6lkrehi 3527 5 the the DT cord-335975-m6lkrehi 3527 6 necessity necessity NN cord-335975-m6lkrehi 3527 7 to to TO cord-335975-m6lkrehi 3527 8 entry entry VB cord-335975-m6lkrehi 3527 9 an an DT cord-335975-m6lkrehi 3527 10 healthcare healthcare NN cord-335975-m6lkrehi 3527 11 institution institution NN cord-335975-m6lkrehi 3527 12 or or CC cord-335975-m6lkrehi 3527 13 the the DT cord-335975-m6lkrehi 3527 14 loss loss NN cord-335975-m6lkrehi 3527 15 of of IN cord-335975-m6lkrehi 3527 16 one one CD cord-335975-m6lkrehi 3527 17 autonomy autonomy NN cord-335975-m6lkrehi 3527 18 point point NN cord-335975-m6lkrehi 3527 19 on on IN cord-335975-m6lkrehi 3527 20 the the DT cord-335975-m6lkrehi 3527 21 ADL ADL NNP cord-335975-m6lkrehi 3527 22 French french JJ cord-335975-m6lkrehi 3527 23 scale scale NN cord-335975-m6lkrehi 3527 24 after after IN cord-335975-m6lkrehi 3527 25 the the DT cord-335975-m6lkrehi 3527 26 hospitalization hospitalization NN cord-335975-m6lkrehi 3527 27 . . . cord-335975-m6lkrehi 3528 1 Results result NNS cord-335975-m6lkrehi 3528 2 : : : cord-335975-m6lkrehi 3528 3 107 107 CD cord-335975-m6lkrehi 3528 4 patients patient NNS cord-335975-m6lkrehi 3528 5 of of IN cord-335975-m6lkrehi 3528 6 the the DT cord-335975-m6lkrehi 3528 7 1763 1763 CD cord-335975-m6lkrehi 3528 8 admissions admission NNS cord-335975-m6lkrehi 3528 9 were be VBD cord-335975-m6lkrehi 3528 10 included include VBN cord-335975-m6lkrehi 3528 11 . . . cord-335975-m6lkrehi 3529 1 The the DT cord-335975-m6lkrehi 3529 2 IGS IGS NNP cord-335975-m6lkrehi 3529 3 II II NNP cord-335975-m6lkrehi 3529 4 and and CC cord-335975-m6lkrehi 3529 5 SOFA sofa NN cord-335975-m6lkrehi 3529 6 average average JJ cord-335975-m6lkrehi 3529 7 scores score NNS cord-335975-m6lkrehi 3529 8 were be VBD cord-335975-m6lkrehi 3529 9 respectively respectively RB cord-335975-m6lkrehi 3529 10 70.23 70.23 CD cord-335975-m6lkrehi 3529 11 ± ± CD cord-335975-m6lkrehi 3529 12 22.47 22.47 CD cord-335975-m6lkrehi 3529 13 and and CC cord-335975-m6lkrehi 3529 14 9.02 9.02 CD cord-335975-m6lkrehi 3529 15 ± ± CD cord-335975-m6lkrehi 3529 16 3.79 3.79 CD cord-335975-m6lkrehi 3529 17 . . . cord-335975-m6lkrehi 3530 1 The the DT cord-335975-m6lkrehi 3530 2 most most RBS cord-335975-m6lkrehi 3530 3 common common JJ cord-335975-m6lkrehi 3530 4 diagnosis diagnosis NN cord-335975-m6lkrehi 3530 5 were be VBD cord-335975-m6lkrehi 3530 6 a a DT cord-335975-m6lkrehi 3530 7 septic septic JJ cord-335975-m6lkrehi 3530 8 shock shock NN cord-335975-m6lkrehi 3530 9 ( ( -LRB- cord-335975-m6lkrehi 3530 10 23 23 CD cord-335975-m6lkrehi 3530 11 patients patient NNS cord-335975-m6lkrehi 3530 12 ) ) -RRB- cord-335975-m6lkrehi 3530 13 , , , cord-335975-m6lkrehi 3530 14 a a DT cord-335975-m6lkrehi 3530 15 cardiopulmonary cardiopulmonary JJ cord-335975-m6lkrehi 3530 16 arrest arrest NN cord-335975-m6lkrehi 3530 17 ( ( -LRB- cord-335975-m6lkrehi 3530 18 21 21 CD cord-335975-m6lkrehi 3530 19 patients patient NNS cord-335975-m6lkrehi 3530 20 ) ) -RRB- cord-335975-m6lkrehi 3530 21 , , , cord-335975-m6lkrehi 3530 22 a a DT cord-335975-m6lkrehi 3530 23 cardiogenic cardiogenic JJ cord-335975-m6lkrehi 3530 24 shock shock NN cord-335975-m6lkrehi 3530 25 ( ( -LRB- cord-335975-m6lkrehi 3530 26 9 9 CD cord-335975-m6lkrehi 3530 27 patients patient NNS cord-335975-m6lkrehi 3530 28 ) ) -RRB- cord-335975-m6lkrehi 3530 29 and and CC cord-335975-m6lkrehi 3530 30 a a DT cord-335975-m6lkrehi 3530 31 pulmonary pulmonary JJ cord-335975-m6lkrehi 3530 32 oedema oedema NN cord-335975-m6lkrehi 3530 33 or or CC cord-335975-m6lkrehi 3530 34 a a DT cord-335975-m6lkrehi 3530 35 lung lung NN cord-335975-m6lkrehi 3530 36 infection infection NN cord-335975-m6lkrehi 3530 37 ( ( -LRB- cord-335975-m6lkrehi 3530 38 8 8 CD cord-335975-m6lkrehi 3530 39 patients patient NNS cord-335975-m6lkrehi 3530 40 Fig Fig NNP cord-335975-m6lkrehi 3530 41 . . . cord-335975-m6lkrehi 3531 1 1 1 CD cord-335975-m6lkrehi 3531 2 Survival survival NN cord-335975-m6lkrehi 3531 3 of of IN cord-335975-m6lkrehi 3531 4 very very RB cord-335975-m6lkrehi 3531 5 old old JJ cord-335975-m6lkrehi 3531 6 patients patient NNS cord-335975-m6lkrehi 3531 7 with with IN cord-335975-m6lkrehi 3531 8 AKI AKI NNP cord-335975-m6lkrehi 3531 9 in in IN cord-335975-m6lkrehi 3531 10 ICU ICU NNP cord-335975-m6lkrehi 3531 11 ( ( -LRB- cord-335975-m6lkrehi 3531 12 % % NN cord-335975-m6lkrehi 3531 13 ) ) -RRB- cord-335975-m6lkrehi 3531 14 each each DT cord-335975-m6lkrehi 3531 15 ) ) -RRB- cord-335975-m6lkrehi 3531 16 . . . cord-335975-m6lkrehi 3532 1 75 75 CD cord-335975-m6lkrehi 3532 2 patients patient NNS cord-335975-m6lkrehi 3532 3 ( ( -LRB- cord-335975-m6lkrehi 3532 4 70.03 70.03 CD cord-335975-m6lkrehi 3532 5 % % NN cord-335975-m6lkrehi 3532 6 ) ) -RRB- cord-335975-m6lkrehi 3532 7 died die VBD cord-335975-m6lkrehi 3532 8 during during IN cord-335975-m6lkrehi 3532 9 the the DT cord-335975-m6lkrehi 3532 10 follow follow NN cord-335975-m6lkrehi 3532 11 up-50 up-50 NNP cord-335975-m6lkrehi 3532 12 at at IN cord-335975-m6lkrehi 3532 13 the the DT cord-335975-m6lkrehi 3532 14 ICU ICU NNP cord-335975-m6lkrehi 3532 15 , , , cord-335975-m6lkrehi 3532 16 13 13 CD cord-335975-m6lkrehi 3532 17 during during IN cord-335975-m6lkrehi 3532 18 ward ward NN cord-335975-m6lkrehi 3532 19 and and CC cord-335975-m6lkrehi 3532 20 12 12 CD cord-335975-m6lkrehi 3532 21 during during IN cord-335975-m6lkrehi 3532 22 re re NN cord-335975-m6lkrehi 3532 23 - - NN cord-335975-m6lkrehi 3532 24 education education NN cord-335975-m6lkrehi 3532 25 or or CC cord-335975-m6lkrehi 3532 26 after after IN cord-335975-m6lkrehi 3532 27 their -PRON- PRP$ cord-335975-m6lkrehi 3532 28 home home NN cord-335975-m6lkrehi 3532 29 return return NN cord-335975-m6lkrehi 3532 30 . . . cord-335975-m6lkrehi 3533 1 From from IN cord-335975-m6lkrehi 3533 2 a a DT cord-335975-m6lkrehi 3533 3 multivariate multivariate JJ cord-335975-m6lkrehi 3533 4 analysis analysis NN cord-335975-m6lkrehi 3533 5 ( ( -LRB- cord-335975-m6lkrehi 3533 6 Table Table NNP cord-335975-m6lkrehi 3533 7 1 1 CD cord-335975-m6lkrehi 3533 8 ) ) -RRB- cord-335975-m6lkrehi 3533 9 , , , cord-335975-m6lkrehi 3533 10 anisocoria anisocoria NNS cord-335975-m6lkrehi 3533 11 , , , cord-335975-m6lkrehi 3533 12 cardiopulmonary cardiopulmonary JJ cord-335975-m6lkrehi 3533 13 arrest arrest NN cord-335975-m6lkrehi 3533 14 and and CC cord-335975-m6lkrehi 3533 15 acute acute JJ cord-335975-m6lkrehi 3533 16 kidney kidney NN cord-335975-m6lkrehi 3533 17 injury injury NN cord-335975-m6lkrehi 3533 18 ( ( -LRB- cord-335975-m6lkrehi 3533 19 AKI AKI NNP cord-335975-m6lkrehi 3533 20 > > XX cord-335975-m6lkrehi 3533 21 0 0 NFP cord-335975-m6lkrehi 3533 22 ) ) -RRB- cord-335975-m6lkrehi 3533 23 seem seem VBP cord-335975-m6lkrehi 3533 24 to to TO cord-335975-m6lkrehi 3533 25 be be VB cord-335975-m6lkrehi 3533 26 independent independent JJ cord-335975-m6lkrehi 3533 27 risk risk NN cord-335975-m6lkrehi 3533 28 factors factor NNS cord-335975-m6lkrehi 3533 29 of of IN cord-335975-m6lkrehi 3533 30 death death NN cord-335975-m6lkrehi 3533 31 . . . cord-335975-m6lkrehi 3534 1 32 32 CD cord-335975-m6lkrehi 3534 2 patients patient NNS cord-335975-m6lkrehi 3534 3 were be VBD cord-335975-m6lkrehi 3534 4 alive alive JJ cord-335975-m6lkrehi 3534 5 at at IN cord-335975-m6lkrehi 3534 6 the the DT cord-335975-m6lkrehi 3534 7 end end NN cord-335975-m6lkrehi 3534 8 of of IN cord-335975-m6lkrehi 3534 9 the the DT cord-335975-m6lkrehi 3534 10 follow follow NN cord-335975-m6lkrehi 3534 11 up up RP cord-335975-m6lkrehi 3534 12 . . . cord-335975-m6lkrehi 3535 1 11 11 CD cord-335975-m6lkrehi 3535 2 recovered recover VBD cord-335975-m6lkrehi 3535 3 their -PRON- PRP$ cord-335975-m6lkrehi 3535 4 previous previous JJ cord-335975-m6lkrehi 3535 5 autonomy autonomy NN cord-335975-m6lkrehi 3535 6 , , , cord-335975-m6lkrehi 3535 7 8 8 CD cord-335975-m6lkrehi 3535 8 needed need VBD cord-335975-m6lkrehi 3535 9 a a DT cord-335975-m6lkrehi 3535 10 place place NN cord-335975-m6lkrehi 3535 11 in in IN cord-335975-m6lkrehi 3535 12 a a DT cord-335975-m6lkrehi 3535 13 specialized specialized JJ cord-335975-m6lkrehi 3535 14 institution institution NN cord-335975-m6lkrehi 3535 15 . . . cord-335975-m6lkrehi 3536 1 All all PDT cord-335975-m6lkrehi 3536 2 the the DT cord-335975-m6lkrehi 3536 3 other other JJ cord-335975-m6lkrehi 3536 4 lost lose VBD cord-335975-m6lkrehi 3536 5 a a DT cord-335975-m6lkrehi 3536 6 part part NN cord-335975-m6lkrehi 3536 7 of of IN cord-335975-m6lkrehi 3536 8 autonomy autonomy NN cord-335975-m6lkrehi 3536 9 3 3 CD cord-335975-m6lkrehi 3536 10 months month NNS cord-335975-m6lkrehi 3536 11 after after IN cord-335975-m6lkrehi 3536 12 their -PRON- PRP$ cord-335975-m6lkrehi 3536 13 home home NN cord-335975-m6lkrehi 3536 14 return return NN cord-335975-m6lkrehi 3536 15 with with IN cord-335975-m6lkrehi 3536 16 the the DT cord-335975-m6lkrehi 3536 17 average average JJ cord-335975-m6lkrehi 3536 18 loss loss NN cord-335975-m6lkrehi 3536 19 of of IN cord-335975-m6lkrehi 3536 20 one one CD cord-335975-m6lkrehi 3536 21 point point NN cord-335975-m6lkrehi 3536 22 on on IN cord-335975-m6lkrehi 3536 23 the the DT cord-335975-m6lkrehi 3536 24 ADL ADL NNP cord-335975-m6lkrehi 3536 25 autonomy autonomy NN cord-335975-m6lkrehi 3536 26 French french JJ cord-335975-m6lkrehi 3536 27 scale scale NN cord-335975-m6lkrehi 3536 28 . . . cord-335975-m6lkrehi 3537 1 Conclusion conclusion NN cord-335975-m6lkrehi 3537 2 : : : cord-335975-m6lkrehi 3538 1 Anisocoria Anisocoria NNP cord-335975-m6lkrehi 3538 2 , , , cord-335975-m6lkrehi 3538 3 AKI AKI NNP cord-335975-m6lkrehi 3538 4 and and CC cord-335975-m6lkrehi 3538 5 cardiopulmonary cardiopulmonary JJ cord-335975-m6lkrehi 3538 6 arrest arrest NN cord-335975-m6lkrehi 3538 7 seem seem VBP cord-335975-m6lkrehi 3538 8 to to TO cord-335975-m6lkrehi 3538 9 be be VB cord-335975-m6lkrehi 3538 10 independent independent JJ cord-335975-m6lkrehi 3538 11 risk risk NN cord-335975-m6lkrehi 3538 12 factors factor NNS cord-335975-m6lkrehi 3538 13 of of IN cord-335975-m6lkrehi 3538 14 death death NN cord-335975-m6lkrehi 3538 15 for for IN cord-335975-m6lkrehi 3538 16 those those DT cord-335975-m6lkrehi 3538 17 patients patient NNS cord-335975-m6lkrehi 3538 18 . . . cord-335975-m6lkrehi 3539 1 Concerning concern VBG cord-335975-m6lkrehi 3539 2 the the DT cord-335975-m6lkrehi 3539 3 survivors survivor NNS cord-335975-m6lkrehi 3539 4 , , , cord-335975-m6lkrehi 3539 5 a a DT cord-335975-m6lkrehi 3539 6 stay stay NN cord-335975-m6lkrehi 3539 7 at at IN cord-335975-m6lkrehi 3539 8 the the DT cord-335975-m6lkrehi 3539 9 ICU ICU NNP cord-335975-m6lkrehi 3539 10 lead lead NN cord-335975-m6lkrehi 3539 11 to to IN cord-335975-m6lkrehi 3539 12 an an DT cord-335975-m6lkrehi 3539 13 increased increase VBN cord-335975-m6lkrehi 3539 14 dependency dependency NN cord-335975-m6lkrehi 3539 15 . . . cord-335975-m6lkrehi 3540 1 Other other JJ cord-335975-m6lkrehi 3540 2 studies study NNS cord-335975-m6lkrehi 3540 3 have have VBP cord-335975-m6lkrehi 3540 4 to to TO cord-335975-m6lkrehi 3540 5 be be VB cord-335975-m6lkrehi 3540 6 led lead VBN cord-335975-m6lkrehi 3540 7 to to TO cord-335975-m6lkrehi 3540 8 evaluate evaluate VB cord-335975-m6lkrehi 3540 9 which which WDT cord-335975-m6lkrehi 3540 10 of of IN cord-335975-m6lkrehi 3540 11 our -PRON- PRP$ cord-335975-m6lkrehi 3540 12 patients patient NNS cord-335975-m6lkrehi 3540 13 could could MD cord-335975-m6lkrehi 3540 14 have have VB cord-335975-m6lkrehi 3540 15 get get VB cord-335975-m6lkrehi 3540 16 the the DT cord-335975-m6lkrehi 3540 17 best good JJS cord-335975-m6lkrehi 3540 18 benefit benefit NN cord-335975-m6lkrehi 3540 19 of of IN cord-335975-m6lkrehi 3540 20 their -PRON- PRP$ cord-335975-m6lkrehi 3540 21 stay stay NN cord-335975-m6lkrehi 3540 22 to to TO cord-335975-m6lkrehi 3540 23 prevent prevent VB cord-335975-m6lkrehi 3540 24 from from IN cord-335975-m6lkrehi 3540 25 a a DT cord-335975-m6lkrehi 3540 26 misuse misuse NN cord-335975-m6lkrehi 3540 27 of of IN cord-335975-m6lkrehi 3540 28 the the DT cord-335975-m6lkrehi 3540 29 structure structure NN cord-335975-m6lkrehi 3540 30 . . . cord-335975-m6lkrehi 3541 1 Introduction introduction NN cord-335975-m6lkrehi 3541 2 : : : cord-335975-m6lkrehi 3541 3 Context- Context- NNP cord-335975-m6lkrehi 3542 1 Among among IN cord-335975-m6lkrehi 3542 2 the the DT cord-335975-m6lkrehi 3542 3 severe severe JJ cord-335975-m6lkrehi 3542 4 complications complication NNS cord-335975-m6lkrehi 3542 5 of of IN cord-335975-m6lkrehi 3542 6 preeclampsia preeclampsia NN cord-335975-m6lkrehi 3542 7 , , , cord-335975-m6lkrehi 3542 8 acute acute JJ cord-335975-m6lkrehi 3542 9 kidney kidney NN cord-335975-m6lkrehi 3542 10 injury injury NN cord-335975-m6lkrehi 3542 11 ( ( -LRB- cord-335975-m6lkrehi 3542 12 AKI AKI NNP cord-335975-m6lkrehi 3542 13 ) ) -RRB- cord-335975-m6lkrehi 3542 14 poses pose VBZ cord-335975-m6lkrehi 3542 15 a a DT cord-335975-m6lkrehi 3542 16 dilemma dilemma NN cord-335975-m6lkrehi 3542 17 if if IN cord-335975-m6lkrehi 3542 18 features feature NNS cord-335975-m6lkrehi 3542 19 of of IN cord-335975-m6lkrehi 3542 20 thrombotic thrombotic JJ cord-335975-m6lkrehi 3542 21 microangiopathy microangiopathy NN cord-335975-m6lkrehi 3542 22 ( ( -LRB- cord-335975-m6lkrehi 3542 23 TMA TMA NNP cord-335975-m6lkrehi 3542 24 ) ) -RRB- cord-335975-m6lkrehi 3542 25 are be VBP cord-335975-m6lkrehi 3542 26 present present JJ cord-335975-m6lkrehi 3542 27 . . . cord-335975-m6lkrehi 3543 1 Although although IN cord-335975-m6lkrehi 3543 2 a a DT cord-335975-m6lkrehi 3543 3 HELLP HELLP NNP cord-335975-m6lkrehi 3543 4 syndrome syndrome NN cord-335975-m6lkrehi 3543 5 is be VBZ cord-335975-m6lkrehi 3543 6 considerably considerably RB cord-335975-m6lkrehi 3543 7 more more RBR cord-335975-m6lkrehi 3543 8 frequent frequent JJ cord-335975-m6lkrehi 3543 9 , , , cord-335975-m6lkrehi 3543 10 ruling rule VBG cord-335975-m6lkrehi 3543 11 out out RP cord-335975-m6lkrehi 3543 12 a a DT cord-335975-m6lkrehi 3543 13 flare flare NN cord-335975-m6lkrehi 3543 14 of of IN cord-335975-m6lkrehi 3543 15 atypical atypical JJ cord-335975-m6lkrehi 3543 16 haemolytic haemolytic JJ cord-335975-m6lkrehi 3543 17 and and CC cord-335975-m6lkrehi 3543 18 uremic uremic JJ cord-335975-m6lkrehi 3543 19 syndrome syndrome NN cord-335975-m6lkrehi 3543 20 ( ( -LRB- cord-335975-m6lkrehi 3543 21 HUS HUS NNP cord-335975-m6lkrehi 3543 22 ) ) -RRB- cord-335975-m6lkrehi 3543 23 is be VBZ cord-335975-m6lkrehi 3543 24 then then RB cord-335975-m6lkrehi 3543 25 of of IN cord-335975-m6lkrehi 3543 26 utmost utmost JJ cord-335975-m6lkrehi 3543 27 importance importance NN cord-335975-m6lkrehi 3543 28 . . . cord-335975-m6lkrehi 3544 1 Objective objective NN cord-335975-m6lkrehi 3544 2 - - : cord-335975-m6lkrehi 3544 3 To to TO cord-335975-m6lkrehi 3544 4 improve improve VB cord-335975-m6lkrehi 3544 5 the the DT cord-335975-m6lkrehi 3544 6 differential differential JJ cord-335975-m6lkrehi 3544 7 diagnosis diagnosis NN cord-335975-m6lkrehi 3544 8 procedure procedure NN cord-335975-m6lkrehi 3544 9 in in IN cord-335975-m6lkrehi 3544 10 cases case NNS cord-335975-m6lkrehi 3544 11 of of IN cord-335975-m6lkrehi 3544 12 post post JJ cord-335975-m6lkrehi 3544 13 - - JJ cord-335975-m6lkrehi 3544 14 partum partum JJ cord-335975-m6lkrehi 3544 15 AKI AKI NNP cord-335975-m6lkrehi 3544 16 . . . cord-335975-m6lkrehi 3545 1 Patients patient NNS cord-335975-m6lkrehi 3545 2 and and CC cord-335975-m6lkrehi 3545 3 methods method NNS cord-335975-m6lkrehi 3545 4 : : : cord-335975-m6lkrehi 3545 5 A a DT cord-335975-m6lkrehi 3545 6 hundred hundred CD cord-335975-m6lkrehi 3545 7 and and CC cord-335975-m6lkrehi 3545 8 five five CD cord-335975-m6lkrehi 3545 9 cases case NNS cord-335975-m6lkrehi 3545 10 of of IN cord-335975-m6lkrehi 3545 11 post post JJ cord-335975-m6lkrehi 3545 12 - - JJ cord-335975-m6lkrehi 3545 13 partum partum JJ cord-335975-m6lkrehi 3545 14 AKI AKI NNP cord-335975-m6lkrehi 3545 15 , , , cord-335975-m6lkrehi 3545 16 admitted admit VBN cord-335975-m6lkrehi 3545 17 in in IN cord-335975-m6lkrehi 3545 18 the the DT cord-335975-m6lkrehi 3545 19 last last JJ cord-335975-m6lkrehi 3545 20 5 5 CD cord-335975-m6lkrehi 3545 21 years year NNS cord-335975-m6lkrehi 3545 22 ( ( -LRB- cord-335975-m6lkrehi 3545 23 2011 2011 CD cord-335975-m6lkrehi 3545 24 ) ) -RRB- cord-335975-m6lkrehi 3546 1 ( ( -LRB- cord-335975-m6lkrehi 3546 2 2012 2012 CD cord-335975-m6lkrehi 3546 3 ) ) -RRB- cord-335975-m6lkrehi 3547 1 ( ( -LRB- cord-335975-m6lkrehi 3547 2 2013 2013 CD cord-335975-m6lkrehi 3547 3 ) ) -RRB- cord-335975-m6lkrehi 3548 1 ( ( -LRB- cord-335975-m6lkrehi 3548 2 2014 2014 CD cord-335975-m6lkrehi 3548 3 ) ) -RRB- cord-335975-m6lkrehi 3548 4 ( ( -LRB- cord-335975-m6lkrehi 3548 5 2015 2015 CD cord-335975-m6lkrehi 3548 6 ) ) -RRB- cord-335975-m6lkrehi 3548 7 in in IN cord-335975-m6lkrehi 3548 8 French French NNP cord-335975-m6lkrehi 3548 9 ICU ICU NNP cord-335975-m6lkrehi 3548 10 from from IN cord-335975-m6lkrehi 3548 11 9 9 CD cord-335975-m6lkrehi 3548 12 different different JJ cord-335975-m6lkrehi 3548 13 regions region NNS cord-335975-m6lkrehi 3548 14 , , , cord-335975-m6lkrehi 3548 15 were be VBD cord-335975-m6lkrehi 3548 16 analysed analyse VBN cord-335975-m6lkrehi 3548 17 . . . cord-335975-m6lkrehi 3549 1 Initial initial JJ cord-335975-m6lkrehi 3549 2 and and CC cord-335975-m6lkrehi 3549 3 final final JJ cord-335975-m6lkrehi 3549 4 diagnosis diagnosis NN cord-335975-m6lkrehi 3549 5 , , , cord-335975-m6lkrehi 3549 6 renal renal JJ cord-335975-m6lkrehi 3549 7 features feature NNS cord-335975-m6lkrehi 3549 8 , , , cord-335975-m6lkrehi 3549 9 haemostasis haemostasis NN cord-335975-m6lkrehi 3549 10 and and CC cord-335975-m6lkrehi 3549 11 TMA TMA NNP cord-335975-m6lkrehi 3549 12 parameters parameter NNS cord-335975-m6lkrehi 3549 13 were be VBD cord-335975-m6lkrehi 3549 14 all all DT cord-335975-m6lkrehi 3549 15 analysed analyse VBN cord-335975-m6lkrehi 3549 16 , , , cord-335975-m6lkrehi 3549 17 paying pay VBG cord-335975-m6lkrehi 3549 18 a a DT cord-335975-m6lkrehi 3549 19 special special JJ cord-335975-m6lkrehi 3549 20 attention attention NN cord-335975-m6lkrehi 3549 21 to to IN cord-335975-m6lkrehi 3549 22 their -PRON- PRP$ cord-335975-m6lkrehi 3549 23 dynamics dynamic NNS cord-335975-m6lkrehi 3549 24 within within IN cord-335975-m6lkrehi 3549 25 the the DT cord-335975-m6lkrehi 3549 26 first first JJ cord-335975-m6lkrehi 3549 27 days day NNS cord-335975-m6lkrehi 3549 28 following follow VBG cord-335975-m6lkrehi 3549 29 the the DT cord-335975-m6lkrehi 3549 30 delivery delivery NN cord-335975-m6lkrehi 3549 31 . . . cord-335975-m6lkrehi 3550 1 Results result NNS cord-335975-m6lkrehi 3550 2 : : : cord-335975-m6lkrehi 3551 1 The the DT cord-335975-m6lkrehi 3551 2 main main JJ cord-335975-m6lkrehi 3551 3 circumstances circumstance NNS cord-335975-m6lkrehi 3551 4 of of IN cord-335975-m6lkrehi 3551 5 AKI AKI NNP cord-335975-m6lkrehi 3551 6 were be VBD cord-335975-m6lkrehi 3551 7 severe severe JJ cord-335975-m6lkrehi 3551 8 preeclampsia preeclampsia NN cord-335975-m6lkrehi 3551 9 ( ( -LRB- cord-335975-m6lkrehi 3551 10 n n NN cord-335975-m6lkrehi 3551 11 = = SYM cord-335975-m6lkrehi 3551 12 40 40 CD cord-335975-m6lkrehi 3551 13 ) ) -RRB- cord-335975-m6lkrehi 3551 14 , , , cord-335975-m6lkrehi 3551 15 post post JJ cord-335975-m6lkrehi 3551 16 - - JJ cord-335975-m6lkrehi 3551 17 partum partum JJ cord-335975-m6lkrehi 3551 18 haemorrhage haemorrhage NN cord-335975-m6lkrehi 3551 19 ( ( -LRB- cord-335975-m6lkrehi 3551 20 PPH pph NN cord-335975-m6lkrehi 3551 21 , , , cord-335975-m6lkrehi 3551 22 n n NN cord-335975-m6lkrehi 3551 23 = = SYM cord-335975-m6lkrehi 3551 24 20 20 CD cord-335975-m6lkrehi 3551 25 ) ) -RRB- cord-335975-m6lkrehi 3551 26 and and CC cord-335975-m6lkrehi 3551 27 primitive primitive JJ cord-335975-m6lkrehi 3551 28 TMA TMA NNP cord-335975-m6lkrehi 3551 29 ( ( -LRB- cord-335975-m6lkrehi 3551 30 n n NN cord-335975-m6lkrehi 3551 31 = = SYM cord-335975-m6lkrehi 3551 32 14 14 CD cord-335975-m6lkrehi 3551 33 , , , cord-335975-m6lkrehi 3551 34 including include VBG cord-335975-m6lkrehi 3551 35 10 10 CD cord-335975-m6lkrehi 3551 36 atypical atypical JJ cord-335975-m6lkrehi 3551 37 HUS hus NN cord-335975-m6lkrehi 3551 38 and and CC cord-335975-m6lkrehi 3551 39 4 4 CD cord-335975-m6lkrehi 3551 40 thrombotic thrombotic JJ cord-335975-m6lkrehi 3551 41 thrombocytopenic thrombocytopenic JJ cord-335975-m6lkrehi 3551 42 purpura purpura NN cord-335975-m6lkrehi 3551 43 ) ) -RRB- cord-335975-m6lkrehi 3551 44 . . . cord-335975-m6lkrehi 3552 1 Among among IN cord-335975-m6lkrehi 3552 2 the the DT cord-335975-m6lkrehi 3552 3 thirteen thirteen CD cord-335975-m6lkrehi 3552 4 cases case NNS cord-335975-m6lkrehi 3552 5 of of IN cord-335975-m6lkrehi 3552 6 renal renal JJ cord-335975-m6lkrehi 3552 7 cortical cortical JJ cord-335975-m6lkrehi 3552 8 necrosis necrosis NN cord-335975-m6lkrehi 3552 9 , , , cord-335975-m6lkrehi 3552 10 11 11 CD cord-335975-m6lkrehi 3552 11 were be VBD cord-335975-m6lkrehi 3552 12 associated associate VBN cord-335975-m6lkrehi 3552 13 with with IN cord-335975-m6lkrehi 3552 14 preeclampsia preeclampsia NN cord-335975-m6lkrehi 3552 15 . . . cord-335975-m6lkrehi 3553 1 Congruence congruence NN cord-335975-m6lkrehi 3553 2 between between IN cord-335975-m6lkrehi 3553 3 the the DT cord-335975-m6lkrehi 3553 4 initial initial JJ cord-335975-m6lkrehi 3553 5 and and CC cord-335975-m6lkrehi 3553 6 the the DT cord-335975-m6lkrehi 3553 7 final final JJ cord-335975-m6lkrehi 3553 8 diagnosis diagnosis NN cord-335975-m6lkrehi 3553 9 was be VBD cord-335975-m6lkrehi 3553 10 low low JJ cord-335975-m6lkrehi 3553 11 ( ( -LRB- cord-335975-m6lkrehi 3553 12 63 63 CD cord-335975-m6lkrehi 3553 13 % % NN cord-335975-m6lkrehi 3553 14 ) ) -RRB- cord-335975-m6lkrehi 3553 15 . . . cord-335975-m6lkrehi 3554 1 Thus thus RB cord-335975-m6lkrehi 3554 2 , , , cord-335975-m6lkrehi 3554 3 none none NN cord-335975-m6lkrehi 3554 4 of of IN cord-335975-m6lkrehi 3554 5 the the DT cord-335975-m6lkrehi 3554 6 women woman NNS cord-335975-m6lkrehi 3554 7 referred refer VBD cord-335975-m6lkrehi 3554 8 to to IN cord-335975-m6lkrehi 3554 9 our -PRON- PRP$ cord-335975-m6lkrehi 3554 10 centers center NNS cord-335975-m6lkrehi 3554 11 for for IN cord-335975-m6lkrehi 3554 12 a a DT cord-335975-m6lkrehi 3554 13 suspicion suspicion NN cord-335975-m6lkrehi 3554 14 of of IN cord-335975-m6lkrehi 3554 15 non non JJ cord-335975-m6lkrehi 3554 16 - - JJ cord-335975-m6lkrehi 3554 17 placental placental JJ cord-335975-m6lkrehi 3554 18 TMA TMA NNP cord-335975-m6lkrehi 3554 19 has have VBZ cord-335975-m6lkrehi 3554 20 received receive VBN cord-335975-m6lkrehi 3554 21 a a DT cord-335975-m6lkrehi 3554 22 final final JJ cord-335975-m6lkrehi 3554 23 diagnosis diagnosis NN cord-335975-m6lkrehi 3554 24 of of IN cord-335975-m6lkrehi 3554 25 non non JJ cord-335975-m6lkrehi 3554 26 - - JJ cord-335975-m6lkrehi 3554 27 placental placental JJ cord-335975-m6lkrehi 3554 28 TMA tma NN cord-335975-m6lkrehi 3554 29 ( ( -LRB- cord-335975-m6lkrehi 3554 30 and and CC cord-335975-m6lkrehi 3554 31 instead instead RB cord-335975-m6lkrehi 3554 32 had have VBD cord-335975-m6lkrehi 3554 33 a a DT cord-335975-m6lkrehi 3554 34 PE PE NNP cord-335975-m6lkrehi 3554 35 or or CC cord-335975-m6lkrehi 3554 36 a a DT cord-335975-m6lkrehi 3554 37 PPH pph NN cord-335975-m6lkrehi 3554 38 ) ) -RRB- cord-335975-m6lkrehi 3554 39 . . . cord-335975-m6lkrehi 3555 1 Conversely conversely RB cord-335975-m6lkrehi 3555 2 , , , cord-335975-m6lkrehi 3555 3 all all DT cord-335975-m6lkrehi 3555 4 women woman NNS cord-335975-m6lkrehi 3555 5 with with IN cord-335975-m6lkrehi 3555 6 a a DT cord-335975-m6lkrehi 3555 7 final final JJ cord-335975-m6lkrehi 3555 8 diagnosis diagnosis NN cord-335975-m6lkrehi 3555 9 of of IN cord-335975-m6lkrehi 3555 10 nonplacental nonplacental NNP cord-335975-m6lkrehi 3555 11 TMA TMA NNP cord-335975-m6lkrehi 3555 12 were be VBD cord-335975-m6lkrehi 3555 13 referred refer VBN cord-335975-m6lkrehi 3555 14 for for IN cord-335975-m6lkrehi 3555 15 a a DT cord-335975-m6lkrehi 3555 16 suspicion suspicion NN cord-335975-m6lkrehi 3555 17 of of IN cord-335975-m6lkrehi 3555 18 PE pe NN cord-335975-m6lkrehi 3555 19 - - HYPH cord-335975-m6lkrehi 3555 20 related relate VBN cord-335975-m6lkrehi 3555 21 TMA TMA NNP cord-335975-m6lkrehi 3555 22 , , , cord-335975-m6lkrehi 3555 23 or or CC cord-335975-m6lkrehi 3555 24 with with IN cord-335975-m6lkrehi 3555 25 a a DT cord-335975-m6lkrehi 3555 26 PPH pph NN cord-335975-m6lkrehi 3555 27 which which WDT cord-335975-m6lkrehi 3555 28 polluted pollute VBD cord-335975-m6lkrehi 3555 29 the the DT cord-335975-m6lkrehi 3555 30 diagnosis diagnosis NN cord-335975-m6lkrehi 3555 31 . . . cord-335975-m6lkrehi 3556 1 Tranexamic tranexamic JJ cord-335975-m6lkrehi 3556 2 acid acid NN cord-335975-m6lkrehi 3556 3 was be VBD cord-335975-m6lkrehi 3556 4 largely largely RB cord-335975-m6lkrehi 3556 5 used use VBN cord-335975-m6lkrehi 3556 6 in in IN cord-335975-m6lkrehi 3556 7 the the DT cord-335975-m6lkrehi 3556 8 context context NN cord-335975-m6lkrehi 3556 9 of of IN cord-335975-m6lkrehi 3556 10 PPH pph NN cord-335975-m6lkrehi 3556 11 ( ( -LRB- cord-335975-m6lkrehi 3556 12 82 82 CD cord-335975-m6lkrehi 3556 13 % % NN cord-335975-m6lkrehi 3556 14 ) ) -RRB- cord-335975-m6lkrehi 3556 15 , , , cord-335975-m6lkrehi 3556 16 at at IN cord-335975-m6lkrehi 3556 17 a a DT cord-335975-m6lkrehi 3556 18 dose dose NN cord-335975-m6lkrehi 3556 19 up up IN cord-335975-m6lkrehi 3556 20 to to TO cord-335975-m6lkrehi 3556 21 5 5 CD cord-335975-m6lkrehi 3556 22 grams gram NNS cord-335975-m6lkrehi 3556 23 total total JJ cord-335975-m6lkrehi 3556 24 . . . cord-335975-m6lkrehi 3557 1 Taking take VBG cord-335975-m6lkrehi 3557 2 into into IN cord-335975-m6lkrehi 3557 3 account account NN cord-335975-m6lkrehi 3557 4 the the DT cord-335975-m6lkrehi 3557 5 final final JJ cord-335975-m6lkrehi 3557 6 diagnosis diagnosis NN cord-335975-m6lkrehi 3557 7 , , , cord-335975-m6lkrehi 3557 8 we -PRON- PRP cord-335975-m6lkrehi 3557 9 subjectively subjectively RB cord-335975-m6lkrehi 3557 10 concluded conclude VBD cord-335975-m6lkrehi 3557 11 that that IN cord-335975-m6lkrehi 3557 12 plasma plasma NN cord-335975-m6lkrehi 3557 13 exchanges exchange NNS cord-335975-m6lkrehi 3557 14 and and CC cord-335975-m6lkrehi 3557 15 eculizumab eculizumab NNS cord-335975-m6lkrehi 3557 16 were be VBD cord-335975-m6lkrehi 3557 17 abusively abusively RB cord-335975-m6lkrehi 3557 18 indicated indicate VBN cord-335975-m6lkrehi 3557 19 in in IN cord-335975-m6lkrehi 3557 20 5 5 CD cord-335975-m6lkrehi 3557 21 and and CC cord-335975-m6lkrehi 3557 22 2 2 CD cord-335975-m6lkrehi 3557 23 cases case NNS cord-335975-m6lkrehi 3557 24 , , , cord-335975-m6lkrehi 3557 25 respectively respectively RB cord-335975-m6lkrehi 3557 26 , , , cord-335975-m6lkrehi 3557 27 of of IN cord-335975-m6lkrehi 3557 28 typical typical JJ cord-335975-m6lkrehi 3557 29 HELLP HELLP NNP cord-335975-m6lkrehi 3557 30 syndrome syndrome NN cord-335975-m6lkrehi 3557 31 . . . cord-335975-m6lkrehi 3558 1 Plasma plasma NN cord-335975-m6lkrehi 3558 2 exchanges exchange NNS cord-335975-m6lkrehi 3558 3 were be VBD cord-335975-m6lkrehi 3558 4 in in IN cord-335975-m6lkrehi 3558 5 itiated itiated JJ cord-335975-m6lkrehi 3558 6 in in IN cord-335975-m6lkrehi 3558 7 all all DT cord-335975-m6lkrehi 3558 8 14 14 CD cord-335975-m6lkrehi 3558 9 cases case NNS cord-335975-m6lkrehi 3558 10 , , , cord-335975-m6lkrehi 3558 11 a a DT cord-335975-m6lkrehi 3558 12 mean mean JJ cord-335975-m6lkrehi 3558 13 84 84 CD cord-335975-m6lkrehi 3558 14 h h NN cord-335975-m6lkrehi 3558 15 following follow VBG cord-335975-m6lkrehi 3558 16 the the DT cord-335975-m6lkrehi 3558 17 admission admission NN cord-335975-m6lkrehi 3558 18 . . . cord-335975-m6lkrehi 3559 1 Dynamics dynamic NNS cord-335975-m6lkrehi 3559 2 of of IN cord-335975-m6lkrehi 3559 3 hemoglobin hemoglobin NN cord-335975-m6lkrehi 3559 4 , , , cord-335975-m6lkrehi 3559 5 haptoglobin haptoglobin NN cord-335975-m6lkrehi 3559 6 , , , cord-335975-m6lkrehi 3559 7 and and CC cord-335975-m6lkrehi 3559 8 liver liver NN cord-335975-m6lkrehi 3559 9 enzymes enzyme NNS cord-335975-m6lkrehi 3559 10 were be VBD cord-335975-m6lkrehi 3559 11 poorly poorly RB cord-335975-m6lkrehi 3559 12 discriminant discriminant JJ cord-335975-m6lkrehi 3559 13 . . . cord-335975-m6lkrehi 3560 1 The the DT cord-335975-m6lkrehi 3560 2 dynamic dynamic JJ cord-335975-m6lkrehi 3560 3 pattern pattern NN cord-335975-m6lkrehi 3560 4 of of IN cord-335975-m6lkrehi 3560 5 LDH LDH NNP cord-335975-m6lkrehi 3560 6 and and CC cord-335975-m6lkrehi 3560 7 of of IN cord-335975-m6lkrehi 3560 8 platelets platelet NNS cord-335975-m6lkrehi 3560 9 , , , cord-335975-m6lkrehi 3560 10 in in IN cord-335975-m6lkrehi 3560 11 contrast contrast NN cord-335975-m6lkrehi 3560 12 , , , cord-335975-m6lkrehi 3560 13 was be VBD cord-335975-m6lkrehi 3560 14 statistically statistically RB cord-335975-m6lkrehi 3560 15 different different JJ cord-335975-m6lkrehi 3560 16 between between IN cord-335975-m6lkrehi 3560 17 primitive primitive JJ cord-335975-m6lkrehi 3560 18 TMA tma NN cord-335975-m6lkrehi 3560 19 - - HYPH cord-335975-m6lkrehi 3560 20 related relate VBN cord-335975-m6lkrehi 3560 21 AKI AKI NNP cord-335975-m6lkrehi 3560 22 and and CC cord-335975-m6lkrehi 3560 23 other other JJ cord-335975-m6lkrehi 3560 24 groups group NNS cord-335975-m6lkrehi 3560 25 - - : cord-335975-m6lkrehi 3560 26 at at IN cord-335975-m6lkrehi 3560 27 day day NN cord-335975-m6lkrehi 3560 28 3 3 CD cord-335975-m6lkrehi 3560 29 , , , cord-335975-m6lkrehi 3560 30 platelets platelet NNS cord-335975-m6lkrehi 3560 31 increased increase VBD cord-335975-m6lkrehi 3560 32 in in IN cord-335975-m6lkrehi 3560 33 preeclamptic preeclamptic JJ cord-335975-m6lkrehi 3560 34 women woman NNS cord-335975-m6lkrehi 3560 35 , , , cord-335975-m6lkrehi 3560 36 and and CC cord-335975-m6lkrehi 3560 37 in in IN cord-335975-m6lkrehi 3560 38 other other JJ cord-335975-m6lkrehi 3560 39 circumstances circumstance NNS cord-335975-m6lkrehi 3560 40 , , , cord-335975-m6lkrehi 3560 41 but but CC cord-335975-m6lkrehi 3560 42 not not RB cord-335975-m6lkrehi 3560 43 in in IN cord-335975-m6lkrehi 3560 44 patients patient NNS cord-335975-m6lkrehi 3560 45 with with IN cord-335975-m6lkrehi 3560 46 primitive primitive JJ cord-335975-m6lkrehi 3560 47 TMA TMA NNP cord-335975-m6lkrehi 3560 48 . . . cord-335975-m6lkrehi 3561 1 A a DT cord-335975-m6lkrehi 3561 2 classification classification NN cord-335975-m6lkrehi 3561 3 and and CC cord-335975-m6lkrehi 3561 4 regression regression NN cord-335975-m6lkrehi 3561 5 tree tree NN cord-335975-m6lkrehi 3561 6 ( ( -LRB- cord-335975-m6lkrehi 3561 7 CART cart NN cord-335975-m6lkrehi 3561 8 ) ) -RRB- cord-335975-m6lkrehi 3561 9 independently independently RB cord-335975-m6lkrehi 3561 10 confirmed confirm VBD cord-335975-m6lkrehi 3561 11 the the DT cord-335975-m6lkrehi 3561 12 usefulness usefulness NN cord-335975-m6lkrehi 3561 13 of of IN cord-335975-m6lkrehi 3561 14 platelets platelet NNS cord-335975-m6lkrehi 3561 15 and and CC cord-335975-m6lkrehi 3561 16 LDH LDH NNP cord-335975-m6lkrehi 3561 17 trajectory trajectory NN cord-335975-m6lkrehi 3561 18 in in IN cord-335975-m6lkrehi 3561 19 the the DT cord-335975-m6lkrehi 3561 20 diagnostic diagnostic JJ cord-335975-m6lkrehi 3561 21 algorithm algorithm NN cord-335975-m6lkrehi 3561 22 ( ( -LRB- cord-335975-m6lkrehi 3561 23 Fig Fig NNP cord-335975-m6lkrehi 3561 24 . . . cord-335975-m6lkrehi 3561 25 1 1 CD cord-335975-m6lkrehi 3561 26 ) ) -RRB- cord-335975-m6lkrehi 3561 27 . . . cord-335975-m6lkrehi 3562 1 Conclusion conclusion NN cord-335975-m6lkrehi 3562 2 : : : cord-335975-m6lkrehi 3563 1 The the DT cord-335975-m6lkrehi 3563 2 trajectory trajectory NN cord-335975-m6lkrehi 3563 3 of of IN cord-335975-m6lkrehi 3563 4 LDH LDH NNP cord-335975-m6lkrehi 3563 5 and and CC cord-335975-m6lkrehi 3563 6 platelet platelet NN cord-335975-m6lkrehi 3563 7 count count NN cord-335975-m6lkrehi 3563 8 is be VBZ cord-335975-m6lkrehi 3563 9 useful useful JJ cord-335975-m6lkrehi 3563 10 to to TO cord-335975-m6lkrehi 3563 11 identify identify VB cord-335975-m6lkrehi 3563 12 the the DT cord-335975-m6lkrehi 3563 13 cause cause NN cord-335975-m6lkrehi 3563 14 of of IN cord-335975-m6lkrehi 3563 15 post post JJ cord-335975-m6lkrehi 3563 16 - - JJ cord-335975-m6lkrehi 3563 17 partum partum JJ cord-335975-m6lkrehi 3563 18 AKI AKI NNP cord-335975-m6lkrehi 3563 19 , , , cord-335975-m6lkrehi 3563 20 and and CC cord-335975-m6lkrehi 3563 21 the the DT cord-335975-m6lkrehi 3563 22 clinician clinician NN cord-335975-m6lkrehi 3563 23 may may MD cord-335975-m6lkrehi 3563 24 reasonably reasonably RB cord-335975-m6lkrehi 3563 25 take take VB cord-335975-m6lkrehi 3563 26 therapeutic therapeutic JJ cord-335975-m6lkrehi 3563 27 decisions decision NNS cord-335975-m6lkrehi 3563 28 at at IN cord-335975-m6lkrehi 3563 29 day day NN cord-335975-m6lkrehi 3563 30 3 3 CD cord-335975-m6lkrehi 3563 31 post post NN cord-335975-m6lkrehi 3563 32 - - NN cord-335975-m6lkrehi 3563 33 delivery delivery NN cord-335975-m6lkrehi 3563 34 . . . cord-335975-m6lkrehi 3564 1 Introduction introduction NN cord-335975-m6lkrehi 3564 2 : : : cord-335975-m6lkrehi 3565 1 Continuous continuous JJ cord-335975-m6lkrehi 3565 2 veno veno NNP cord-335975-m6lkrehi 3565 3 - - HYPH cord-335975-m6lkrehi 3565 4 venous venous JJ cord-335975-m6lkrehi 3565 5 hemofiltration hemofiltration NN cord-335975-m6lkrehi 3565 6 ( ( -LRB- cord-335975-m6lkrehi 3565 7 CVVHF CVVHF NNP cord-335975-m6lkrehi 3565 8 ) ) -RRB- cord-335975-m6lkrehi 3565 9 is be VBZ cord-335975-m6lkrehi 3565 10 a a DT cord-335975-m6lkrehi 3565 11 common common JJ cord-335975-m6lkrehi 3565 12 practice practice NN cord-335975-m6lkrehi 3565 13 in in IN cord-335975-m6lkrehi 3565 14 intensive intensive JJ cord-335975-m6lkrehi 3565 15 care care NN cord-335975-m6lkrehi 3565 16 units unit NNS cord-335975-m6lkrehi 3565 17 ( ( -LRB- cord-335975-m6lkrehi 3565 18 ICU ICU NNP cord-335975-m6lkrehi 3565 19 ) ) -RRB- cord-335975-m6lkrehi 3565 20 . . . cord-335975-m6lkrehi 3566 1 Because because IN cord-335975-m6lkrehi 3566 2 it -PRON- PRP cord-335975-m6lkrehi 3566 3 is be VBZ cord-335975-m6lkrehi 3566 4 continuous continuous JJ cord-335975-m6lkrehi 3566 5 , , , cord-335975-m6lkrehi 3566 6 the the DT cord-335975-m6lkrehi 3566 7 choice choice NN cord-335975-m6lkrehi 3566 8 of of IN cord-335975-m6lkrehi 3566 9 anticoagulation anticoagulation NN cord-335975-m6lkrehi 3566 10 is be VBZ cord-335975-m6lkrehi 3566 11 essential essential JJ cord-335975-m6lkrehi 3566 12 - - HYPH cord-335975-m6lkrehi 3566 13 regional regional JJ cord-335975-m6lkrehi 3566 14 anticoagulation anticoagulation NN cord-335975-m6lkrehi 3566 15 Fig Fig NNP cord-335975-m6lkrehi 3566 16 . . . cord-335975-m6lkrehi 3567 1 1 1 LS cord-335975-m6lkrehi 3567 2 Analysis Analysis NNP cord-335975-m6lkrehi 3567 3 of of IN cord-335975-m6lkrehi 3567 4 post post JJ cord-335975-m6lkrehi 3567 5 - - JJ cord-335975-m6lkrehi 3567 6 partum partum JJ cord-335975-m6lkrehi 3567 7 AKI AKI NNP cord-335975-m6lkrehi 3567 8 cases case NNS cord-335975-m6lkrehi 3567 9 with with IN cord-335975-m6lkrehi 3567 10 citrate citrate NN cord-335975-m6lkrehi 3567 11 or or CC cord-335975-m6lkrehi 3567 12 systemic systemic JJ cord-335975-m6lkrehi 3567 13 with with IN cord-335975-m6lkrehi 3567 14 unfractionned unfractionned JJ cord-335975-m6lkrehi 3567 15 heparin heparin NN cord-335975-m6lkrehi 3567 16 or or CC cord-335975-m6lkrehi 3567 17 low low JJ cord-335975-m6lkrehi 3567 18 molecular molecular JJ cord-335975-m6lkrehi 3567 19 weight weight NN cord-335975-m6lkrehi 3567 20 heparin heparin NN cord-335975-m6lkrehi 3567 21 ( ( -LRB- cord-335975-m6lkrehi 3567 22 LMWH LMWH NNP cord-335975-m6lkrehi 3567 23 ) ) -RRB- cord-335975-m6lkrehi 3567 24 . . . cord-335975-m6lkrehi 3568 1 Filter Filter NNP cord-335975-m6lkrehi 3568 2 's 's POS cord-335975-m6lkrehi 3568 3 lifespan lifespan NN cord-335975-m6lkrehi 3568 4 is be VBZ cord-335975-m6lkrehi 3568 5 a a DT cord-335975-m6lkrehi 3568 6 major major JJ cord-335975-m6lkrehi 3568 7 issue issue NN cord-335975-m6lkrehi 3568 8 regarding regard VBG cord-335975-m6lkrehi 3568 9 filtration filtration NN cord-335975-m6lkrehi 3568 10 's 's POS cord-335975-m6lkrehi 3568 11 effectiveness effectiveness NN cord-335975-m6lkrehi 3568 12 and and CC cord-335975-m6lkrehi 3568 13 cost cost NN cord-335975-m6lkrehi 3568 14 . . . cord-335975-m6lkrehi 3569 1 In in IN cord-335975-m6lkrehi 3569 2 this this DT cord-335975-m6lkrehi 3569 3 study study NN cord-335975-m6lkrehi 3569 4 , , , cord-335975-m6lkrehi 3569 5 we -PRON- PRP cord-335975-m6lkrehi 3569 6 compared compare VBD cord-335975-m6lkrehi 3569 7 the the DT cord-335975-m6lkrehi 3569 8 filter filter NN cord-335975-m6lkrehi 3569 9 's 's POS cord-335975-m6lkrehi 3569 10 lifespan lifespan NN cord-335975-m6lkrehi 3569 11 between between IN cord-335975-m6lkrehi 3569 12 LMWH LMWH NNP cord-335975-m6lkrehi 3569 13 and and CC cord-335975-m6lkrehi 3569 14 citrate citrate NN cord-335975-m6lkrehi 3569 15 anticoagulation anticoagulation NN cord-335975-m6lkrehi 3569 16 . . . cord-335975-m6lkrehi 3570 1 Patients patient NNS cord-335975-m6lkrehi 3570 2 and and CC cord-335975-m6lkrehi 3570 3 methods method NNS cord-335975-m6lkrehi 3570 4 : : : cord-335975-m6lkrehi 3570 5 A a DT cord-335975-m6lkrehi 3570 6 monocentric monocentric JJ cord-335975-m6lkrehi 3570 7 retrospective retrospective JJ cord-335975-m6lkrehi 3570 8 study study NN cord-335975-m6lkrehi 3570 9 was be VBD cord-335975-m6lkrehi 3570 10 led lead VBN cord-335975-m6lkrehi 3570 11 from from IN cord-335975-m6lkrehi 3570 12 January January NNP cord-335975-m6lkrehi 3570 13 to to IN cord-335975-m6lkrehi 3570 14 October October NNP cord-335975-m6lkrehi 3570 15 2016 2016 CD cord-335975-m6lkrehi 3570 16 . . . cord-335975-m6lkrehi 3571 1 All all PDT cord-335975-m6lkrehi 3571 2 the the DT cord-335975-m6lkrehi 3571 3 CVVHF CVVHF NNP cord-335975-m6lkrehi 3571 4 sessions session NNS cord-335975-m6lkrehi 3571 5 during during IN cord-335975-m6lkrehi 3571 6 this this DT cord-335975-m6lkrehi 3571 7 period period NN cord-335975-m6lkrehi 3571 8 were be VBD cord-335975-m6lkrehi 3571 9 included include VBN cord-335975-m6lkrehi 3571 10 . . . cord-335975-m6lkrehi 3572 1 Prismaflex Prismaflex NNP cord-335975-m6lkrehi 3572 2 © © NN cord-335975-m6lkrehi 3572 3 monitors monitor NNS cord-335975-m6lkrehi 3572 4 ( ( -LRB- cord-335975-m6lkrehi 3572 5 Hospal Hospal NNP cord-335975-m6lkrehi 3572 6 ) ) -RRB- cord-335975-m6lkrehi 3572 7 were be VBD cord-335975-m6lkrehi 3572 8 used use VBN cord-335975-m6lkrehi 3572 9 . . . cord-335975-m6lkrehi 3573 1 Practioners practioner NNS cord-335975-m6lkrehi 3573 2 were be VBD cord-335975-m6lkrehi 3573 3 free free JJ cord-335975-m6lkrehi 3573 4 to to TO cord-335975-m6lkrehi 3573 5 choose choose VB cord-335975-m6lkrehi 3573 6 between between IN cord-335975-m6lkrehi 3573 7 citrate citrate NN cord-335975-m6lkrehi 3573 8 or or CC cord-335975-m6lkrehi 3573 9 LMWH LMWH NNP cord-335975-m6lkrehi 3573 10 defining define VBG cord-335975-m6lkrehi 3573 11 2 2 CD cord-335975-m6lkrehi 3573 12 groups group NNS cord-335975-m6lkrehi 3573 13 . . . cord-335975-m6lkrehi 3574 1 We -PRON- PRP cord-335975-m6lkrehi 3574 2 aimed aim VBD cord-335975-m6lkrehi 3574 3 a a DT cord-335975-m6lkrehi 3574 4 post post NN cord-335975-m6lkrehi 3574 5 filter filter NN cord-335975-m6lkrehi 3574 6 ionized ionize VBN cord-335975-m6lkrehi 3574 7 calcemia calcemia NN cord-335975-m6lkrehi 3574 8 between between IN cord-335975-m6lkrehi 3574 9 0.25 0.25 CD cord-335975-m6lkrehi 3574 10 to to IN cord-335975-m6lkrehi 3574 11 0.5 0.5 CD cord-335975-m6lkrehi 3574 12 mmol mmol NNP cord-335975-m6lkrehi 3574 13 / / SYM cord-335975-m6lkrehi 3574 14 L L NNP cord-335975-m6lkrehi 3574 15 in in IN cord-335975-m6lkrehi 3574 16 citrate citrate NN cord-335975-m6lkrehi 3574 17 group group NN cord-335975-m6lkrehi 3574 18 + + CC cord-335975-m6lkrehi 3574 19 and and CC cord-335975-m6lkrehi 3574 20 a a DT cord-335975-m6lkrehi 3574 21 post post NN cord-335975-m6lkrehi 3574 22 filter filter NN cord-335975-m6lkrehi 3574 23 anti anti JJ cord-335975-m6lkrehi 3574 24 Xa Xa NNP cord-335975-m6lkrehi 3574 25 activity activity NN cord-335975-m6lkrehi 3574 26 between between IN cord-335975-m6lkrehi 3574 27 0.2 0.2 CD cord-335975-m6lkrehi 3574 28 to to IN cord-335975-m6lkrehi 3574 29 0.5 0.5 CD cord-335975-m6lkrehi 3574 30 UI UI NNP cord-335975-m6lkrehi 3574 31 / / SYM cord-335975-m6lkrehi 3574 32 mL ml NN cord-335975-m6lkrehi 3574 33 in in IN cord-335975-m6lkrehi 3574 34 LMWH LMWH NNP cord-335975-m6lkrehi 3574 35 . . . cord-335975-m6lkrehi 3575 1 Results result NNS cord-335975-m6lkrehi 3575 2 : : : cord-335975-m6lkrehi 3576 1 95 95 CD cord-335975-m6lkrehi 3576 2 CVVHF CVVHF NNP cord-335975-m6lkrehi 3576 3 sessions session NNS cord-335975-m6lkrehi 3576 4 were be VBD cord-335975-m6lkrehi 3576 5 included-64 included-64 NNP cord-335975-m6lkrehi 3576 6 with with IN cord-335975-m6lkrehi 3576 7 LMWH LMWH NNP cord-335975-m6lkrehi 3576 8 anticoagulation anticoagulation NN cord-335975-m6lkrehi 3576 9 , , , cord-335975-m6lkrehi 3576 10 and and CC cord-335975-m6lkrehi 3576 11 31 31 CD cord-335975-m6lkrehi 3576 12 with with IN cord-335975-m6lkrehi 3576 13 citrate citrate NNP cord-335975-m6lkrehi 3576 14 . . . cord-335975-m6lkrehi 3577 1 Patients patient NNS cord-335975-m6lkrehi 3577 2 were be VBD cord-335975-m6lkrehi 3577 3 62 62 CD cord-335975-m6lkrehi 3577 4 years year NNS cord-335975-m6lkrehi 3577 5 old old JJ cord-335975-m6lkrehi 3577 6 on on IN cord-335975-m6lkrehi 3577 7 average average JJ cord-335975-m6lkrehi 3577 8 , , , cord-335975-m6lkrehi 3577 9 primarly primarly RB cord-335975-m6lkrehi 3577 10 males male NNS cord-335975-m6lkrehi 3577 11 ( ( -LRB- cord-335975-m6lkrehi 3577 12 65 65 CD cord-335975-m6lkrehi 3577 13 % % NN cord-335975-m6lkrehi 3577 14 ) ) -RRB- cord-335975-m6lkrehi 3577 15 , , , cord-335975-m6lkrehi 3577 16 with with IN cord-335975-m6lkrehi 3577 17 an an DT cord-335975-m6lkrehi 3577 18 initial initial JJ cord-335975-m6lkrehi 3577 19 average average JJ cord-335975-m6lkrehi 3577 20 SAPS SAPS NNP cord-335975-m6lkrehi 3577 21 II II NNP cord-335975-m6lkrehi 3577 22 score score NN cord-335975-m6lkrehi 3577 23 of of IN cord-335975-m6lkrehi 3577 24 73 73 CD cord-335975-m6lkrehi 3577 25 . . . cord-335975-m6lkrehi 3578 1 ICU ICU NNP cord-335975-m6lkrehi 3578 2 mortality mortality NN cord-335975-m6lkrehi 3578 3 was be VBD cord-335975-m6lkrehi 3578 4 51 51 CD cord-335975-m6lkrehi 3578 5 % % NN cord-335975-m6lkrehi 3578 6 . . . cord-335975-m6lkrehi 3579 1 Patients patient NNS cord-335975-m6lkrehi 3579 2 ' ' POS cord-335975-m6lkrehi 3579 3 hemostasis hemostasis NN cord-335975-m6lkrehi 3579 4 was be VBD cord-335975-m6lkrehi 3579 5 measured measure VBN cord-335975-m6lkrehi 3579 6 before before IN cord-335975-m6lkrehi 3579 7 each each DT cord-335975-m6lkrehi 3579 8 CVVHF CVVHF NNP cord-335975-m6lkrehi 3579 9 session session NN cord-335975-m6lkrehi 3579 10 , , , cord-335975-m6lkrehi 3579 11 without without IN cord-335975-m6lkrehi 3579 12 any any DT cord-335975-m6lkrehi 3579 13 significant significant JJ cord-335975-m6lkrehi 3579 14 difference difference NN cord-335975-m6lkrehi 3579 15 between between IN cord-335975-m6lkrehi 3579 16 the the DT cord-335975-m6lkrehi 3579 17 2 2 CD cord-335975-m6lkrehi 3579 18 groups group NNS cord-335975-m6lkrehi 3579 19 . . . cord-335975-m6lkrehi 3580 1 Global global JJ cord-335975-m6lkrehi 3580 2 filter filter NN cord-335975-m6lkrehi 3580 3 's 's POS cord-335975-m6lkrehi 3580 4 lifespan lifespan NN cord-335975-m6lkrehi 3580 5 was be VBD cord-335975-m6lkrehi 3580 6 47 47 CD cord-335975-m6lkrehi 3580 7 h h NN cord-335975-m6lkrehi 3580 8 + + SYM cord-335975-m6lkrehi 3580 9 54 54 CD cord-335975-m6lkrehi 3580 10 h h NN cord-335975-m6lkrehi 3580 11 in in IN cord-335975-m6lkrehi 3580 12 citrate citrate NN cord-335975-m6lkrehi 3580 13 group group NN cord-335975-m6lkrehi 3580 14 versus versus IN cord-335975-m6lkrehi 3580 15 44H 44H NNP cord-335975-m6lkrehi 3580 16 in in IN cord-335975-m6lkrehi 3580 17 LMWH LMWH NNP cord-335975-m6lkrehi 3580 18 , , , cord-335975-m6lkrehi 3580 19 without without IN cord-335975-m6lkrehi 3580 20 significant significant JJ cord-335975-m6lkrehi 3580 21 difference difference NN cord-335975-m6lkrehi 3580 22 ( ( -LRB- cord-335975-m6lkrehi 3580 23 p p NN cord-335975-m6lkrehi 3580 24 = = SYM cord-335975-m6lkrehi 3580 25 0.236 0.236 CD cord-335975-m6lkrehi 3580 26 ) ) -RRB- cord-335975-m6lkrehi 3581 1 ( ( -LRB- cord-335975-m6lkrehi 3581 2 Fig Fig NNP cord-335975-m6lkrehi 3581 3 . . NNP cord-335975-m6lkrehi 3581 4 1 1 CD cord-335975-m6lkrehi 3581 5 ) ) -RRB- cord-335975-m6lkrehi 3581 6 . . . cord-335975-m6lkrehi 3582 1 No no DT cord-335975-m6lkrehi 3582 2 serious serious JJ cord-335975-m6lkrehi 3582 3 side side NN cord-335975-m6lkrehi 3582 4 effect effect NN cord-335975-m6lkrehi 3582 5 , , , cord-335975-m6lkrehi 3582 6 especially especially RB cord-335975-m6lkrehi 3582 7 hemorrhage hemorrhage NN cord-335975-m6lkrehi 3582 8 in in IN cord-335975-m6lkrehi 3582 9 the the DT cord-335975-m6lkrehi 3582 10 LMWH LMWH NNP cord-335975-m6lkrehi 3582 11 group group NN cord-335975-m6lkrehi 3582 12 , , , cord-335975-m6lkrehi 3582 13 was be VBD cord-335975-m6lkrehi 3582 14 reported report VBN cord-335975-m6lkrehi 3582 15 . . . cord-335975-m6lkrehi 3583 1 Filtration filtration NN cord-335975-m6lkrehi 3583 2 efficiency efficiency NN cord-335975-m6lkrehi 3583 3 , , , cord-335975-m6lkrehi 3583 4 represented represent VBN cord-335975-m6lkrehi 3583 5 by by IN cord-335975-m6lkrehi 3583 6 the the DT cord-335975-m6lkrehi 3583 7 urea urea NN cord-335975-m6lkrehi 3583 8 reduction reduction NN cord-335975-m6lkrehi 3583 9 ratio ratio NN cord-335975-m6lkrehi 3583 10 during during IN cord-335975-m6lkrehi 3583 11 the the DT cord-335975-m6lkrehi 3583 12 first first JJ cord-335975-m6lkrehi 3583 13 CVVHF CVVHF NNP cord-335975-m6lkrehi 3583 14 session session NN cord-335975-m6lkrehi 3583 15 , , , cord-335975-m6lkrehi 3583 16 was be VBD cord-335975-m6lkrehi 3583 17 similar similar JJ cord-335975-m6lkrehi 3583 18 , , , cord-335975-m6lkrehi 3583 19 30 30 CD cord-335975-m6lkrehi 3583 20 % % NN cord-335975-m6lkrehi 3583 21 ± ± CD cord-335975-m6lkrehi 3583 22 20 20 CD cord-335975-m6lkrehi 3583 23 % % NN cord-335975-m6lkrehi 3583 24 in in IN cord-335975-m6lkrehi 3583 25 LMWH LMWH NNP cord-335975-m6lkrehi 3583 26 group group NN cord-335975-m6lkrehi 3583 27 versus versus IN cord-335975-m6lkrehi 3583 28 20 20 CD cord-335975-m6lkrehi 3583 29 % % NN cord-335975-m6lkrehi 3583 30 ± ± CD cord-335975-m6lkrehi 3583 31 20 20 CD cord-335975-m6lkrehi 3583 32 % % NN cord-335975-m6lkrehi 3583 33 in in IN cord-335975-m6lkrehi 3583 34 citrate citrate NN cord-335975-m6lkrehi 3583 35 group group NN cord-335975-m6lkrehi 3583 36 ( ( -LRB- cord-335975-m6lkrehi 3583 37 p p NN cord-335975-m6lkrehi 3583 38 = = SYM cord-335975-m6lkrehi 3583 39 0.235 0.235 CD cord-335975-m6lkrehi 3583 40 ) ) -RRB- cord-335975-m6lkrehi 3583 41 . . . cord-335975-m6lkrehi 3584 1 Conclusion conclusion NN cord-335975-m6lkrehi 3584 2 : : : cord-335975-m6lkrehi 3584 3 Both both CC cord-335975-m6lkrehi 3584 4 anticoagulation anticoagulation NN cord-335975-m6lkrehi 3584 5 - - HYPH cord-335975-m6lkrehi 3584 6 systemic systemic JJ cord-335975-m6lkrehi 3584 7 with with IN cord-335975-m6lkrehi 3584 8 LMWH LMWH NNP cord-335975-m6lkrehi 3584 9 or or CC cord-335975-m6lkrehi 3584 10 regional regional JJ cord-335975-m6lkrehi 3584 11 with with IN cord-335975-m6lkrehi 3584 12 citrate citrate NNP cord-335975-m6lkrehi 3584 13 can can MD cord-335975-m6lkrehi 3584 14 be be VB cord-335975-m6lkrehi 3584 15 used use VBN cord-335975-m6lkrehi 3584 16 in in IN cord-335975-m6lkrehi 3584 17 ICU ICU NNP cord-335975-m6lkrehi 3584 18 . . . cord-335975-m6lkrehi 3585 1 Both both DT cord-335975-m6lkrehi 3585 2 methods method NNS cord-335975-m6lkrehi 3585 3 enable enable VBP cord-335975-m6lkrehi 3585 4 long long JJ cord-335975-m6lkrehi 3585 5 and and CC cord-335975-m6lkrehi 3585 6 comparable comparable JJ cord-335975-m6lkrehi 3585 7 filter filter NN cord-335975-m6lkrehi 3585 8 lifespan lifespan NN cord-335975-m6lkrehi 3585 9 , , , cord-335975-m6lkrehi 3585 10 with with IN cord-335975-m6lkrehi 3585 11 similar similar JJ cord-335975-m6lkrehi 3585 12 filtration filtration NN cord-335975-m6lkrehi 3585 13 efficiency efficiency NN cord-335975-m6lkrehi 3585 14 and and CC cord-335975-m6lkrehi 3585 15 without without IN cord-335975-m6lkrehi 3585 16 serious serious JJ cord-335975-m6lkrehi 3585 17 adverse adverse JJ cord-335975-m6lkrehi 3585 18 events event NNS cord-335975-m6lkrehi 3585 19 . . . cord-335975-m6lkrehi 3586 1 Our -PRON- PRP$ cord-335975-m6lkrehi 3586 2 results result NNS cord-335975-m6lkrehi 3586 3 need need VBP cord-335975-m6lkrehi 3586 4 to to TO cord-335975-m6lkrehi 3586 5 be be VB cord-335975-m6lkrehi 3586 6 confirmed confirm VBN cord-335975-m6lkrehi 3586 7 by by IN cord-335975-m6lkrehi 3586 8 a a DT cord-335975-m6lkrehi 3586 9 randomized randomized JJ cord-335975-m6lkrehi 3586 10 propective propective JJ cord-335975-m6lkrehi 3586 11 study study NN cord-335975-m6lkrehi 3586 12 . . . cord-335975-m6lkrehi 3587 1 Introduction introduction NN cord-335975-m6lkrehi 3587 2 : : : cord-335975-m6lkrehi 3587 3 ARF arf NN cord-335975-m6lkrehi 3587 4 during during IN cord-335975-m6lkrehi 3587 5 the the DT cord-335975-m6lkrehi 3587 6 post post JJ cord-335975-m6lkrehi 3587 7 - - JJ cord-335975-m6lkrehi 3587 8 partum partum JJ cord-335975-m6lkrehi 3587 9 period period NN cord-335975-m6lkrehi 3587 10 is be VBZ cord-335975-m6lkrehi 3587 11 a a DT cord-335975-m6lkrehi 3587 12 rare rare JJ cord-335975-m6lkrehi 3587 13 complication complication NN cord-335975-m6lkrehi 3587 14 . . . cord-335975-m6lkrehi 3588 1 The the DT cord-335975-m6lkrehi 3588 2 main main JJ cord-335975-m6lkrehi 3588 3 etiologies etiology NNS cord-335975-m6lkrehi 3588 4 are be VBP cord-335975-m6lkrehi 3588 5 post post JJ cord-335975-m6lkrehi 3588 6 - - JJ cord-335975-m6lkrehi 3588 7 partum partum JJ cord-335975-m6lkrehi 3588 8 haemorrhage haemorrhage NN cord-335975-m6lkrehi 3588 9 ( ( -LRB- cord-335975-m6lkrehi 3588 10 PPH pph NN cord-335975-m6lkrehi 3588 11 ) ) -RRB- cord-335975-m6lkrehi 3588 12 and and CC cord-335975-m6lkrehi 3588 13 thrombotic thrombotic JJ cord-335975-m6lkrehi 3588 14 microangiopathy microangiopathy NNP cord-335975-m6lkrehi 3588 15 ( ( -LRB- cord-335975-m6lkrehi 3588 16 TMA TMA NNP cord-335975-m6lkrehi 3588 17 ) ) -RRB- cord-335975-m6lkrehi 3588 18 . . . cord-335975-m6lkrehi 3589 1 RRT RRT NNP cord-335975-m6lkrehi 3589 2 may may MD cord-335975-m6lkrehi 3589 3 be be VB cord-335975-m6lkrehi 3589 4 required require VBN cord-335975-m6lkrehi 3589 5 . . . cord-335975-m6lkrehi 3590 1 The the DT cord-335975-m6lkrehi 3590 2 aim aim NN cord-335975-m6lkrehi 3590 3 of of IN cord-335975-m6lkrehi 3590 4 this this DT cord-335975-m6lkrehi 3590 5 study study NN cord-335975-m6lkrehi 3590 6 was be VBD cord-335975-m6lkrehi 3590 7 to to TO cord-335975-m6lkrehi 3590 8 identify identify VB cord-335975-m6lkrehi 3590 9 variables variable NNS cord-335975-m6lkrehi 3590 10 associated associate VBN cord-335975-m6lkrehi 3590 11 with with IN cord-335975-m6lkrehi 3590 12 RRT RRT NNP cord-335975-m6lkrehi 3590 13 in in IN cord-335975-m6lkrehi 3590 14 this this DT cord-335975-m6lkrehi 3590 15 population population NN cord-335975-m6lkrehi 3590 16 admitted admit VBD cord-335975-m6lkrehi 3590 17 in in IN cord-335975-m6lkrehi 3590 18 ICU ICU NNP cord-335975-m6lkrehi 3590 19 . . . cord-335975-m6lkrehi 3591 1 Patients patient NNS cord-335975-m6lkrehi 3591 2 and and CC cord-335975-m6lkrehi 3591 3 methods method NNS cord-335975-m6lkrehi 3592 1 : : : cord-335975-m6lkrehi 3592 2 We -PRON- PRP cord-335975-m6lkrehi 3592 3 conducted conduct VBD cord-335975-m6lkrehi 3592 4 a a DT cord-335975-m6lkrehi 3592 5 study study NN cord-335975-m6lkrehi 3592 6 using use VBG cord-335975-m6lkrehi 3592 7 retrospectively retrospectively RB cord-335975-m6lkrehi 3592 8 collected collect VBN cord-335975-m6lkrehi 3592 9 data datum NNS cord-335975-m6lkrehi 3592 10 in in IN cord-335975-m6lkrehi 3592 11 a a DT cord-335975-m6lkrehi 3592 12 cohort cohort NN cord-335975-m6lkrehi 3592 13 of of IN cord-335975-m6lkrehi 3592 14 patient patient NN cord-335975-m6lkrehi 3592 15 with with IN cord-335975-m6lkrehi 3592 16 post post JJ cord-335975-m6lkrehi 3592 17 - - JJ cord-335975-m6lkrehi 3592 18 partum partum JJ cord-335975-m6lkrehi 3592 19 ARF arf NN cord-335975-m6lkrehi 3592 20 according accord VBG cord-335975-m6lkrehi 3592 21 to to IN cord-335975-m6lkrehi 3592 22 the the DT cord-335975-m6lkrehi 3592 23 KDIGO KDIGO NNP cord-335975-m6lkrehi 3592 24 criteria criterion NNS cord-335975-m6lkrehi 3592 25 and and CC cord-335975-m6lkrehi 3592 26 requiring require VBG cord-335975-m6lkrehi 3592 27 ICU ICU NNP cord-335975-m6lkrehi 3592 28 in in IN cord-335975-m6lkrehi 3592 29 the the DT cord-335975-m6lkrehi 3592 30 University University NNP cord-335975-m6lkrehi 3592 31 hospital hospital NN cord-335975-m6lkrehi 3592 32 of of IN cord-335975-m6lkrehi 3592 33 Lille Lille NNP cord-335975-m6lkrehi 3592 34 from from IN cord-335975-m6lkrehi 3592 35 2008 2008 CD cord-335975-m6lkrehi 3592 36 until until IN cord-335975-m6lkrehi 3592 37 2016 2016 CD cord-335975-m6lkrehi 3592 38 . . . cord-335975-m6lkrehi 3593 1 Two two CD cord-335975-m6lkrehi 3593 2 groups group NNS cord-335975-m6lkrehi 3593 3 were be VBD cord-335975-m6lkrehi 3593 4 compared compare VBN cord-335975-m6lkrehi 3593 5 - - HYPH cord-335975-m6lkrehi 3593 6 RRT rrt NN cord-335975-m6lkrehi 3593 7 and and CC cord-335975-m6lkrehi 3593 8 non non JJ cord-335975-m6lkrehi 3593 9 RRT RRT NNP cord-335975-m6lkrehi 3593 10 patients patient NNS cord-335975-m6lkrehi 3593 11 . . . cord-335975-m6lkrehi 3594 1 Demographic demographic JJ cord-335975-m6lkrehi 3594 2 and and CC cord-335975-m6lkrehi 3594 3 obstetrical obstetrical JJ cord-335975-m6lkrehi 3594 4 data datum NNS cord-335975-m6lkrehi 3594 5 as as RB cord-335975-m6lkrehi 3594 6 well well RB cord-335975-m6lkrehi 3594 7 as as IN cord-335975-m6lkrehi 3594 8 data datum NNS cord-335975-m6lkrehi 3594 9 during during IN cord-335975-m6lkrehi 3594 10 ICU ICU NNP cord-335975-m6lkrehi 3594 11 stay stay NN cord-335975-m6lkrehi 3594 12 and and CC cord-335975-m6lkrehi 3594 13 patients patient NNS cord-335975-m6lkrehi 3594 14 ' ' POS cord-335975-m6lkrehi 3594 15 outcome outcome NN cord-335975-m6lkrehi 3594 16 were be VBD cord-335975-m6lkrehi 3594 17 collected collect VBN cord-335975-m6lkrehi 3594 18 . . . cord-335975-m6lkrehi 3595 1 Etiologies Etiologies NNP cord-335975-m6lkrehi 3595 2 of of IN cord-335975-m6lkrehi 3595 3 ARF ARF NNP cord-335975-m6lkrehi 3595 4 , , , cord-335975-m6lkrehi 3595 5 KDIGO KDIGO NNP cord-335975-m6lkrehi 3595 6 stage stage NN cord-335975-m6lkrehi 3595 7 , , , cord-335975-m6lkrehi 3595 8 anuria anuria NN cord-335975-m6lkrehi 3595 9 , , , cord-335975-m6lkrehi 3595 10 hemolysis hemolysis NN cord-335975-m6lkrehi 3595 11 parameters parameter NNS cord-335975-m6lkrehi 3595 12 and and CC cord-335975-m6lkrehi 3595 13 biological biological JJ cord-335975-m6lkrehi 3595 14 data datum NNS cord-335975-m6lkrehi 3595 15 at at IN cord-335975-m6lkrehi 3595 16 ICU ICU NNP cord-335975-m6lkrehi 3595 17 admission admission NN cord-335975-m6lkrehi 3595 18 were be VBD cord-335975-m6lkrehi 3595 19 studied study VBN cord-335975-m6lkrehi 3595 20 . . . cord-335975-m6lkrehi 3596 1 Comparisons comparison NNS cord-335975-m6lkrehi 3596 2 were be VBD cord-335975-m6lkrehi 3596 3 made make VBN cord-335975-m6lkrehi 3596 4 using use VBG cord-335975-m6lkrehi 3596 5 a a DT cord-335975-m6lkrehi 3596 6 Chi Chi NNP cord-335975-m6lkrehi 3596 7 - - HYPH cord-335975-m6lkrehi 3596 8 two two CD cord-335975-m6lkrehi 3596 9 or or CC cord-335975-m6lkrehi 3596 10 Fisher Fisher NNP cord-335975-m6lkrehi 3596 11 Exact Exact NNP cord-335975-m6lkrehi 3596 12 test test NN cord-335975-m6lkrehi 3596 13 or or CC cord-335975-m6lkrehi 3596 14 a a DT cord-335975-m6lkrehi 3596 15 Mann Mann NNP cord-335975-m6lkrehi 3596 16 - - HYPH cord-335975-m6lkrehi 3596 17 Whitney Whitney NNP cord-335975-m6lkrehi 3596 18 U U NNP cord-335975-m6lkrehi 3596 19 test test NN cord-335975-m6lkrehi 3596 20 . . . cord-335975-m6lkrehi 3597 1 Odds Odds NNPS cord-335975-m6lkrehi 3597 2 Ratio ratio NN cord-335975-m6lkrehi 3597 3 ( ( -LRB- cord-335975-m6lkrehi 3597 4 OR OR NNP cord-335975-m6lkrehi 3597 5 ) ) -RRB- cord-335975-m6lkrehi 3597 6 for for IN cord-335975-m6lkrehi 3597 7 the the DT cord-335975-m6lkrehi 3597 8 statistically statistically RB cord-335975-m6lkrehi 3597 9 different different JJ cord-335975-m6lkrehi 3597 10 criteria criterion NNS cord-335975-m6lkrehi 3597 11 were be VBD cord-335975-m6lkrehi 3597 12 studied study VBN cord-335975-m6lkrehi 3597 13 . . . cord-335975-m6lkrehi 3598 1 Results result NNS cord-335975-m6lkrehi 3598 2 : : : cord-335975-m6lkrehi 3599 1 Twenty twenty CD cord-335975-m6lkrehi 3599 2 - - HYPH cord-335975-m6lkrehi 3599 3 two two CD cord-335975-m6lkrehi 3599 4 patients patient NNS cord-335975-m6lkrehi 3599 5 requiring require VBG cord-335975-m6lkrehi 3599 6 RRT rrt PRP cord-335975-m6lkrehi 3599 7 were be VBD cord-335975-m6lkrehi 3599 8 compared compare VBN cord-335975-m6lkrehi 3599 9 to to IN cord-335975-m6lkrehi 3599 10 the the DT cord-335975-m6lkrehi 3599 11 49 49 CD cord-335975-m6lkrehi 3599 12 patients patient NNS cord-335975-m6lkrehi 3599 13 without without IN cord-335975-m6lkrehi 3599 14 RRT RRT NNP cord-335975-m6lkrehi 3599 15 . . . cord-335975-m6lkrehi 3600 1 The the DT cord-335975-m6lkrehi 3600 2 two two CD cord-335975-m6lkrehi 3600 3 main main JJ cord-335975-m6lkrehi 3600 4 etiologies etiology NNS cord-335975-m6lkrehi 3600 5 of of IN cord-335975-m6lkrehi 3600 6 ARF arf NN cord-335975-m6lkrehi 3600 7 were be VBD cord-335975-m6lkrehi 3600 8 TMA TMA NNP cord-335975-m6lkrehi 3600 9 ( ( -LRB- cord-335975-m6lkrehi 3600 10 50.7 50.7 CD cord-335975-m6lkrehi 3600 11 % % NN cord-335975-m6lkrehi 3600 12 ) ) -RRB- cord-335975-m6lkrehi 3600 13 and and CC cord-335975-m6lkrehi 3600 14 PPH pph NN cord-335975-m6lkrehi 3600 15 ( ( -LRB- cord-335975-m6lkrehi 3600 16 35.2 35.2 CD cord-335975-m6lkrehi 3600 17 % % NN cord-335975-m6lkrehi 3600 18 ) ) -RRB- cord-335975-m6lkrehi 3600 19 . . . cord-335975-m6lkrehi 3601 1 Vaginal vaginal JJ cord-335975-m6lkrehi 3601 2 delivery delivery NN cord-335975-m6lkrehi 3601 3 was be VBD cord-335975-m6lkrehi 3601 4 significantly significantly RB cord-335975-m6lkrehi 3601 5 more more RBR cord-335975-m6lkrehi 3601 6 frequent frequent JJ cord-335975-m6lkrehi 3601 7 in in IN cord-335975-m6lkrehi 3601 8 the the DT cord-335975-m6lkrehi 3601 9 RRT RRT NNP cord-335975-m6lkrehi 3601 10 group group NN cord-335975-m6lkrehi 3601 11 compared compare VBN cord-335975-m6lkrehi 3601 12 with with IN cord-335975-m6lkrehi 3601 13 caesarian caesarian JJ cord-335975-m6lkrehi 3601 14 delivery delivery NN cord-335975-m6lkrehi 3601 15 ( ( -LRB- cord-335975-m6lkrehi 3601 16 p p NN cord-335975-m6lkrehi 3601 17 = = SYM cord-335975-m6lkrehi 3601 18 0.04 0.04 CD cord-335975-m6lkrehi 3601 19 ) ) -RRB- cord-335975-m6lkrehi 3601 20 . . . cord-335975-m6lkrehi 3602 1 Use use NN cord-335975-m6lkrehi 3602 2 of of IN cord-335975-m6lkrehi 3602 3 RTT RTT NNP cord-335975-m6lkrehi 3602 4 was be VBD cord-335975-m6lkrehi 3602 5 significantly significantly RB cord-335975-m6lkrehi 3602 6 increased increase VBN cord-335975-m6lkrehi 3602 7 after after IN cord-335975-m6lkrehi 3602 8 PPH pph NN cord-335975-m6lkrehi 3602 9 compared compare VBD cord-335975-m6lkrehi 3602 10 the the DT cord-335975-m6lkrehi 3602 11 others other NNS cord-335975-m6lkrehi 3602 12 etiology etiology NN cord-335975-m6lkrehi 3602 13 of of IN cord-335975-m6lkrehi 3602 14 ARF arf NN cord-335975-m6lkrehi 3602 15 ( ( -LRB- cord-335975-m6lkrehi 3602 16 p p NN cord-335975-m6lkrehi 3602 17 = = SYM cord-335975-m6lkrehi 3602 18 0.03 0.03 CD cord-335975-m6lkrehi 3602 19 ) ) -RRB- cord-335975-m6lkrehi 3602 20 . . . cord-335975-m6lkrehi 3603 1 In in IN cord-335975-m6lkrehi 3603 2 the the DT cord-335975-m6lkrehi 3603 3 RRT RRT NNP cord-335975-m6lkrehi 3603 4 group group NN cord-335975-m6lkrehi 3603 5 , , , cord-335975-m6lkrehi 3603 6 the the DT cord-335975-m6lkrehi 3603 7 ICU ICU NNP cord-335975-m6lkrehi 3603 8 length length NN cord-335975-m6lkrehi 3603 9 of of IN cord-335975-m6lkrehi 3603 10 stay stay NN cord-335975-m6lkrehi 3603 11 was be VBD cord-335975-m6lkrehi 3603 12 longer long JJR cord-335975-m6lkrehi 3603 13 ( ( -LRB- cord-335975-m6lkrehi 3603 14 p p NN cord-335975-m6lkrehi 3603 15 < < XX cord-335975-m6lkrehi 3603 16 0.0001 0.0001 CD cord-335975-m6lkrehi 3603 17 ) ) -RRB- cord-335975-m6lkrehi 3603 18 and and CC cord-335975-m6lkrehi 3603 19 IGS IGS NNP cord-335975-m6lkrehi 3603 20 II II NNP cord-335975-m6lkrehi 3603 21 score score NN cord-335975-m6lkrehi 3603 22 was be VBD cord-335975-m6lkrehi 3603 23 higher high JJR cord-335975-m6lkrehi 3603 24 ( ( -LRB- cord-335975-m6lkrehi 3603 25 p p NN cord-335975-m6lkrehi 3603 26 < < XX cord-335975-m6lkrehi 3603 27 0.0001 0.0001 CD cord-335975-m6lkrehi 3603 28 ) ) -RRB- cord-335975-m6lkrehi 3603 29 . . . cord-335975-m6lkrehi 3604 1 Higher high JJR cord-335975-m6lkrehi 3604 2 KDIGO KDIGO NNP cord-335975-m6lkrehi 3604 3 score score NN cord-335975-m6lkrehi 3604 4 was be VBD cord-335975-m6lkrehi 3604 5 observed observe VBN cord-335975-m6lkrehi 3604 6 in in IN cord-335975-m6lkrehi 3604 7 RRT RRT NNP cord-335975-m6lkrehi 3604 8 patients patient NNS cord-335975-m6lkrehi 3604 9 ( ( -LRB- cord-335975-m6lkrehi 3604 10 in in IN cord-335975-m6lkrehi 3604 11 the the DT cord-335975-m6lkrehi 3604 12 RRT RRT NNP cord-335975-m6lkrehi 3604 13 group group NN cord-335975-m6lkrehi 3604 14 - - HYPH cord-335975-m6lkrehi 3604 15 KDIGO KDIGO NNP cord-335975-m6lkrehi 3604 16 1 1 CD cord-335975-m6lkrehi 3604 17 = = SYM cord-335975-m6lkrehi 3604 18 0 0 CD cord-335975-m6lkrehi 3604 19 , , , cord-335975-m6lkrehi 3604 20 2 2 CD cord-335975-m6lkrehi 3604 21 = = SYM cord-335975-m6lkrehi 3604 22 9 9 CD cord-335975-m6lkrehi 3604 23 % % NN cord-335975-m6lkrehi 3604 24 , , , cord-335975-m6lkrehi 3604 25 3 3 CD cord-335975-m6lkrehi 3604 26 = = SYM cord-335975-m6lkrehi 3604 27 91 91 CD cord-335975-m6lkrehi 3604 28 % % NN cord-335975-m6lkrehi 3604 29 , , , cord-335975-m6lkrehi 3604 30 and and CC cord-335975-m6lkrehi 3604 31 without without IN cord-335975-m6lkrehi 3604 32 RRT rrt NN cord-335975-m6lkrehi 3604 33 - - HYPH cord-335975-m6lkrehi 3604 34 KDIGO KDIGO NNP cord-335975-m6lkrehi 3604 35 1 1 CD cord-335975-m6lkrehi 3604 36 = = SYM cord-335975-m6lkrehi 3604 37 38.8 38.8 CD cord-335975-m6lkrehi 3604 38 % % NN cord-335975-m6lkrehi 3604 39 , , , cord-335975-m6lkrehi 3604 40 2 2 CD cord-335975-m6lkrehi 3604 41 = = SYM cord-335975-m6lkrehi 3604 42 36 36 CD cord-335975-m6lkrehi 3604 43 % % NN cord-335975-m6lkrehi 3604 44 , , , cord-335975-m6lkrehi 3604 45 3 3 CD cord-335975-m6lkrehi 3604 46 = = SYM cord-335975-m6lkrehi 3604 47 36 36 CD cord-335975-m6lkrehi 3604 48 % % NN cord-335975-m6lkrehi 3604 49 , , , cord-335975-m6lkrehi 3604 50 p p NN cord-335975-m6lkrehi 3604 51 < < XX cord-335975-m6lkrehi 3604 52 0.0001 0.0001 CD cord-335975-m6lkrehi 3604 53 ) ) -RRB- cord-335975-m6lkrehi 3604 54 . . . cord-335975-m6lkrehi 3605 1 Anuria Anuria NNP cord-335975-m6lkrehi 3605 2 24 24 CD cord-335975-m6lkrehi 3605 3 h h NN cord-335975-m6lkrehi 3605 4 after after IN cord-335975-m6lkrehi 3605 5 ICU ICU NNP cord-335975-m6lkrehi 3605 6 admission admission NN cord-335975-m6lkrehi 3605 7 was be VBD cord-335975-m6lkrehi 3605 8 more more RBR cord-335975-m6lkrehi 3605 9 frequent frequent JJ cord-335975-m6lkrehi 3605 10 in in IN cord-335975-m6lkrehi 3605 11 cases case NNS cord-335975-m6lkrehi 3605 12 of of IN cord-335975-m6lkrehi 3605 13 RTT RTT NNP cord-335975-m6lkrehi 3605 14 ( ( -LRB- cord-335975-m6lkrehi 3605 15 86.3 86.3 CD cord-335975-m6lkrehi 3605 16 % % NN cord-335975-m6lkrehi 3605 17 versus versus IN cord-335975-m6lkrehi 3605 18 20.3 20.3 CD cord-335975-m6lkrehi 3605 19 % % NN cord-335975-m6lkrehi 3605 20 , , , cord-335975-m6lkrehi 3605 21 p p NN cord-335975-m6lkrehi 3605 22 < < XX cord-335975-m6lkrehi 3605 23 0.0001 0.0001 CD cord-335975-m6lkrehi 3605 24 ) ) -RRB- cord-335975-m6lkrehi 3605 25 . . . cord-335975-m6lkrehi 3606 1 Hemolysis Hemolysis NNP cord-335975-m6lkrehi 3606 2 was be VBD cord-335975-m6lkrehi 3606 3 greater great JJR cord-335975-m6lkrehi 3606 4 in in IN cord-335975-m6lkrehi 3606 5 RRT RRT NNP cord-335975-m6lkrehi 3606 6 patients patient NNS cord-335975-m6lkrehi 3606 7 with with IN cord-335975-m6lkrehi 3606 8 lower low JJR cord-335975-m6lkrehi 3606 9 haptoglobin haptoglobin NN cord-335975-m6lkrehi 3606 10 ( ( -LRB- cord-335975-m6lkrehi 3606 11 p p NN cord-335975-m6lkrehi 3606 12 = = SYM cord-335975-m6lkrehi 3606 13 0.02 0.02 CD cord-335975-m6lkrehi 3606 14 ) ) -RRB- cord-335975-m6lkrehi 3606 15 and and CC cord-335975-m6lkrehi 3606 16 increased increase VBD cord-335975-m6lkrehi 3606 17 Lactate Lactate NNP cord-335975-m6lkrehi 3606 18 Deshydrogenase Deshydrogenase NNP cord-335975-m6lkrehi 3606 19 ( ( -LRB- cord-335975-m6lkrehi 3606 20 LDH LDH NNP cord-335975-m6lkrehi 3606 21 ) ) -RRB- cord-335975-m6lkrehi 3606 22 ( ( -LRB- cord-335975-m6lkrehi 3606 23 p p NN cord-335975-m6lkrehi 3606 24 = = SYM cord-335975-m6lkrehi 3606 25 0.04 0.04 CD cord-335975-m6lkrehi 3606 26 ) ) -RRB- cord-335975-m6lkrehi 3606 27 . . . cord-335975-m6lkrehi 3607 1 The the DT cord-335975-m6lkrehi 3607 2 association association NN cord-335975-m6lkrehi 3607 3 with with IN cord-335975-m6lkrehi 3607 4 RRT RRT NNP cord-335975-m6lkrehi 3607 5 requirement requirement NN cord-335975-m6lkrehi 3607 6 was be VBD cord-335975-m6lkrehi 3607 7 stronger strong JJR cord-335975-m6lkrehi 3607 8 with with IN cord-335975-m6lkrehi 3607 9 the the DT cord-335975-m6lkrehi 3607 10 duration duration NN cord-335975-m6lkrehi 3607 11 of of IN cord-335975-m6lkrehi 3607 12 anuria anuria NNP cord-335975-m6lkrehi 3607 13 , , , cord-335975-m6lkrehi 3607 14 with with IN cord-335975-m6lkrehi 3607 15 an an DT cord-335975-m6lkrehi 3607 16 OR or CC cord-335975-m6lkrehi 3607 17 at at IN cord-335975-m6lkrehi 3607 18 6 6 CD cord-335975-m6lkrehi 3607 19 h h NN cord-335975-m6lkrehi 3607 20 at at IN cord-335975-m6lkrehi 3607 21 31 31 CD cord-335975-m6lkrehi 3607 22 . . . cord-335975-m6lkrehi 3608 1 3 3 LS cord-335975-m6lkrehi 3608 2 [ [ -LRB- cord-335975-m6lkrehi 3608 3 8.1 8.1 CD cord-335975-m6lkrehi 3608 4 - - HYPH cord-335975-m6lkrehi 3608 5 121.7 121.7 CD cord-335975-m6lkrehi 3608 6 ] ] -RRB- cord-335975-m6lkrehi 3609 1 and and CC cord-335975-m6lkrehi 3609 2 at at IN cord-335975-m6lkrehi 3609 3 24 24 CD cord-335975-m6lkrehi 3609 4 h h NN cord-335975-m6lkrehi 3609 5 at at IN cord-335975-m6lkrehi 3609 6 72 72 CD cord-335975-m6lkrehi 3609 7 . . . cord-335975-m6lkrehi 3609 8 2 2 CD cord-335975-m6lkrehi 3609 9 [ [ -LRB- cord-335975-m6lkrehi 3609 10 8.3 8.3 CD cord-335975-m6lkrehi 3609 11 - - SYM cord-335975-m6lkrehi 3609 12 622 622 CD cord-335975-m6lkrehi 3609 13 ] ] -RRB- cord-335975-m6lkrehi 3609 14 . . . cord-335975-m6lkrehi 3610 1 A a DT cord-335975-m6lkrehi 3610 2 lower low JJR cord-335975-m6lkrehi 3610 3 haptoglobin haptoglobin NN cord-335975-m6lkrehi 3610 4 was be VBD cord-335975-m6lkrehi 3610 5 associated associate VBN cord-335975-m6lkrehi 3610 6 with with IN cord-335975-m6lkrehi 3610 7 a a DT cord-335975-m6lkrehi 3610 8 higher high JJR cord-335975-m6lkrehi 3610 9 risk risk NN cord-335975-m6lkrehi 3610 10 of of IN cord-335975-m6lkrehi 3610 11 RTT RTT NNP cord-335975-m6lkrehi 3610 12 ( ( -LRB- cord-335975-m6lkrehi 3610 13 OR or CC cord-335975-m6lkrehi 3610 14 3.7 3.7 CD cord-335975-m6lkrehi 3610 15 [ [ -LRB- cord-335975-m6lkrehi 3610 16 1.2 1.2 CD cord-335975-m6lkrehi 3610 17 - - SYM cord-335975-m6lkrehi 3610 18 11.7 11.7 CD cord-335975-m6lkrehi 3610 19 ] ] -RRB- cord-335975-m6lkrehi 3610 20 ) ) -RRB- cord-335975-m6lkrehi 3610 21 , , , cord-335975-m6lkrehi 3610 22 as as RB cord-335975-m6lkrehi 3610 23 well well RB cord-335975-m6lkrehi 3610 24 as as IN cord-335975-m6lkrehi 3610 25 PPH pph NN cord-335975-m6lkrehi 3610 26 ( ( -LRB- cord-335975-m6lkrehi 3610 27 OR or CC cord-335975-m6lkrehi 3610 28 3.1 3.1 CD cord-335975-m6lkrehi 3610 29 [ [ -LRB- cord-335975-m6lkrehi 3610 30 1.1 1.1 CD cord-335975-m6lkrehi 3610 31 - - SYM cord-335975-m6lkrehi 3610 32 8.8 8.8 CD cord-335975-m6lkrehi 3610 33 ] ] -RRB- cord-335975-m6lkrehi 3610 34 ) ) -RRB- cord-335975-m6lkrehi 3610 35 and and CC cord-335975-m6lkrehi 3610 36 vaginal vaginal JJ cord-335975-m6lkrehi 3610 37 delivery delivery NN cord-335975-m6lkrehi 3610 38 ( ( -LRB- cord-335975-m6lkrehi 3610 39 OR or CC cord-335975-m6lkrehi 3610 40 2.9 2.9 CD cord-335975-m6lkrehi 3610 41 [ [ -LRB- cord-335975-m6lkrehi 3610 42 1.02 1.02 CD cord-335975-m6lkrehi 3610 43 - - SYM cord-335975-m6lkrehi 3610 44 8.1 8.1 CD cord-335975-m6lkrehi 3610 45 ] ] -RRB- cord-335975-m6lkrehi 3610 46 ) ) -RRB- cord-335975-m6lkrehi 3610 47 . . . cord-335975-m6lkrehi 3611 1 Conclusion conclusion NN cord-335975-m6lkrehi 3611 2 : : : cord-335975-m6lkrehi 3612 1 Hemolysis Hemolysis NNP cord-335975-m6lkrehi 3612 2 parameters parameter NNS cord-335975-m6lkrehi 3612 3 and and CC cord-335975-m6lkrehi 3612 4 anuria anuria NNP cord-335975-m6lkrehi 3612 5 seemed seem VBD cord-335975-m6lkrehi 3612 6 useful useful JJ cord-335975-m6lkrehi 3612 7 criteria criterion NNS cord-335975-m6lkrehi 3612 8 to to TO cord-335975-m6lkrehi 3612 9 identify identify VB cord-335975-m6lkrehi 3612 10 patients patient NNS cord-335975-m6lkrehi 3612 11 at at IN cord-335975-m6lkrehi 3612 12 higher high JJR cord-335975-m6lkrehi 3612 13 risk risk NN cord-335975-m6lkrehi 3612 14 of of IN cord-335975-m6lkrehi 3612 15 RRT RRT NNP cord-335975-m6lkrehi 3612 16 early early RB cord-335975-m6lkrehi 3612 17 during during IN cord-335975-m6lkrehi 3612 18 their -PRON- PRP$ cord-335975-m6lkrehi 3612 19 ICU ICU NNP cord-335975-m6lkrehi 3612 20 admission admission NN cord-335975-m6lkrehi 3612 21 . . . cord-335975-m6lkrehi 3613 1 Introduction introduction NN cord-335975-m6lkrehi 3613 2 : : : cord-335975-m6lkrehi 3613 3 Renal renal JJ cord-335975-m6lkrehi 3613 4 replacement replacement NN cord-335975-m6lkrehi 3613 5 therapy therapy NN cord-335975-m6lkrehi 3613 6 ( ( -LRB- cord-335975-m6lkrehi 3613 7 RRT RRT NNP cord-335975-m6lkrehi 3613 8 ) ) -RRB- cord-335975-m6lkrehi 3613 9 has have VBZ cord-335975-m6lkrehi 3613 10 three three CD cord-335975-m6lkrehi 3613 11 aimsrestoring aimsrestore VBG cord-335975-m6lkrehi 3613 12 homeostasis homeostasis NN cord-335975-m6lkrehi 3613 13 , , , cord-335975-m6lkrehi 3613 14 ensuring ensure VBG cord-335975-m6lkrehi 3613 15 survival survival NN cord-335975-m6lkrehi 3613 16 and and CC cord-335975-m6lkrehi 3613 17 preserving preserve VBG cord-335975-m6lkrehi 3613 18 the the DT cord-335975-m6lkrehi 3613 19 potential potential NN cord-335975-m6lkrehi 3613 20 for for IN cord-335975-m6lkrehi 3613 21 renal renal JJ cord-335975-m6lkrehi 3613 22 recovery recovery NN cord-335975-m6lkrehi 3613 23 . . . cord-335975-m6lkrehi 3614 1 The the DT cord-335975-m6lkrehi 3614 2 main main JJ cord-335975-m6lkrehi 3614 3 indication indication NN cord-335975-m6lkrehi 3614 4 of of IN cord-335975-m6lkrehi 3614 5 RRT RRT NNP cord-335975-m6lkrehi 3614 6 in in IN cord-335975-m6lkrehi 3614 7 ICU ICU NNP cord-335975-m6lkrehi 3614 8 is be VBZ cord-335975-m6lkrehi 3614 9 acute acute JJ cord-335975-m6lkrehi 3614 10 renal renal JJ cord-335975-m6lkrehi 3614 11 failure failure NN cord-335975-m6lkrehi 3614 12 , , , cord-335975-m6lkrehi 3614 13 correlated correlate VBN cord-335975-m6lkrehi 3614 14 with with IN cord-335975-m6lkrehi 3614 15 a a DT cord-335975-m6lkrehi 3614 16 very very RB cord-335975-m6lkrehi 3614 17 important important JJ cord-335975-m6lkrehi 3614 18 rate rate NN cord-335975-m6lkrehi 3614 19 of of IN cord-335975-m6lkrehi 3614 20 mortality mortality NN cord-335975-m6lkrehi 3614 21 despite despite IN cord-335975-m6lkrehi 3614 22 the the DT cord-335975-m6lkrehi 3614 23 progress progress NN cord-335975-m6lkrehi 3614 24 made make VBN cord-335975-m6lkrehi 3614 25 in in IN cord-335975-m6lkrehi 3614 26 its -PRON- PRP$ cord-335975-m6lkrehi 3614 27 management management NN cord-335975-m6lkrehi 3614 28 . . . cord-335975-m6lkrehi 3615 1 Patients patient NNS cord-335975-m6lkrehi 3615 2 and and CC cord-335975-m6lkrehi 3615 3 methods method NNS cord-335975-m6lkrehi 3615 4 : : : cord-335975-m6lkrehi 3615 5 The the DT cord-335975-m6lkrehi 3615 6 objective objective NN cord-335975-m6lkrehi 3615 7 of of IN cord-335975-m6lkrehi 3615 8 this this DT cord-335975-m6lkrehi 3615 9 work work NN cord-335975-m6lkrehi 3615 10 is be VBZ cord-335975-m6lkrehi 3615 11 to to TO cord-335975-m6lkrehi 3615 12 take take VB cord-335975-m6lkrehi 3615 13 stock stock NN cord-335975-m6lkrehi 3615 14 of of IN cord-335975-m6lkrehi 3615 15 the the DT cord-335975-m6lkrehi 3615 16 indications indication NNS cord-335975-m6lkrehi 3615 17 and and CC cord-335975-m6lkrehi 3615 18 the the DT cord-335975-m6lkrehi 3615 19 objectives objective NNS cord-335975-m6lkrehi 3615 20 of of IN cord-335975-m6lkrehi 3615 21 the the DT cord-335975-m6lkrehi 3615 22 RRT RRT NNP cord-335975-m6lkrehi 3615 23 in in IN cord-335975-m6lkrehi 3615 24 ICU ICU NNP cord-335975-m6lkrehi 3615 25 . . . cord-335975-m6lkrehi 3616 1 Through through IN cord-335975-m6lkrehi 3616 2 a a DT cord-335975-m6lkrehi 3616 3 prospective prospective JJ cord-335975-m6lkrehi 3616 4 study study NN cord-335975-m6lkrehi 3616 5 , , , cord-335975-m6lkrehi 3616 6 we -PRON- PRP cord-335975-m6lkrehi 3616 7 report report VBP cord-335975-m6lkrehi 3616 8 a a DT cord-335975-m6lkrehi 3616 9 serie serie NN cord-335975-m6lkrehi 3616 10 of of IN cord-335975-m6lkrehi 3616 11 39 39 CD cord-335975-m6lkrehi 3616 12 cases case NNS cord-335975-m6lkrehi 3616 13 , , , cord-335975-m6lkrehi 3616 14 collected collect VBN cord-335975-m6lkrehi 3616 15 at at IN cord-335975-m6lkrehi 3616 16 the the DT cord-335975-m6lkrehi 3616 17 multipurpose multipurpose JJ cord-335975-m6lkrehi 3616 18 resuscitation resuscitation NN cord-335975-m6lkrehi 3616 19 unit unit NN cord-335975-m6lkrehi 3616 20 of of IN cord-335975-m6lkrehi 3616 21 the the DT cord-335975-m6lkrehi 3616 22 Avicenna Avicenna NNP cord-335975-m6lkrehi 3616 23 military military JJ cord-335975-m6lkrehi 3616 24 hospital hospital NN cord-335975-m6lkrehi 3616 25 in in IN cord-335975-m6lkrehi 3616 26 Marrakech Marrakech NNP cord-335975-m6lkrehi 3616 27 between between IN cord-335975-m6lkrehi 3616 28 September September NNP cord-335975-m6lkrehi 3616 29 2015 2015 CD cord-335975-m6lkrehi 3616 30 and and CC cord-335975-m6lkrehi 3616 31 September September NNP cord-335975-m6lkrehi 3616 32 2016 2016 CD cord-335975-m6lkrehi 3616 33 . . . cord-335975-m6lkrehi 3617 1 Results result NNS cord-335975-m6lkrehi 3617 2 : : : cord-335975-m6lkrehi 3618 1 The the DT cord-335975-m6lkrehi 3618 2 average average JJ cord-335975-m6lkrehi 3618 3 age age NN cord-335975-m6lkrehi 3618 4 of of IN cord-335975-m6lkrehi 3618 5 our -PRON- PRP$ cord-335975-m6lkrehi 3618 6 patients patient NNS cord-335975-m6lkrehi 3618 7 is be VBZ cord-335975-m6lkrehi 3618 8 65 65 CD cord-335975-m6lkrehi 3618 9 , , , cord-335975-m6lkrehi 3618 10 10 10 CD cord-335975-m6lkrehi 3618 11 ± ± NNP cord-335975-m6lkrehi 3618 12 24 24 CD cord-335975-m6lkrehi 3618 13 , , , cord-335975-m6lkrehi 3618 14 89 89 CD cord-335975-m6lkrehi 3618 15 years year NNS cord-335975-m6lkrehi 3618 16 with with IN cord-335975-m6lkrehi 3618 17 extremes extreme NNS cord-335975-m6lkrehi 3618 18 ranging range VBG cord-335975-m6lkrehi 3618 19 from from IN cord-335975-m6lkrehi 3618 20 34 34 CD cord-335975-m6lkrehi 3618 21 to to TO cord-335975-m6lkrehi 3618 22 90 90 CD cord-335975-m6lkrehi 3618 23 years year NNS cord-335975-m6lkrehi 3618 24 and and CC cord-335975-m6lkrehi 3618 25 a a DT cord-335975-m6lkrehi 3618 26 male male JJ cord-335975-m6lkrehi 3618 27 predominance predominance NN cord-335975-m6lkrehi 3618 28 ( ( -LRB- cord-335975-m6lkrehi 3618 29 77 77 CD cord-335975-m6lkrehi 3618 30 % % NN cord-335975-m6lkrehi 3618 31 ) ) -RRB- cord-335975-m6lkrehi 3618 32 . . . cord-335975-m6lkrehi 3619 1 The the DT cord-335975-m6lkrehi 3619 2 main main JJ cord-335975-m6lkrehi 3619 3 reasons reason NNS cord-335975-m6lkrehi 3619 4 for for IN cord-335975-m6lkrehi 3619 5 admission admission NN cord-335975-m6lkrehi 3619 6 were be VBD cord-335975-m6lkrehi 3619 7 hemodynamic hemodynamic JJ cord-335975-m6lkrehi 3619 8 distress distress NN cord-335975-m6lkrehi 3619 9 in in IN cord-335975-m6lkrehi 3619 10 43.5 43.5 CD cord-335975-m6lkrehi 3619 11 % % NN cord-335975-m6lkrehi 3619 12 of of IN cord-335975-m6lkrehi 3619 13 cases case NNS cord-335975-m6lkrehi 3619 14 , , , cord-335975-m6lkrehi 3619 15 followed follow VBN cord-335975-m6lkrehi 3619 16 by by IN cord-335975-m6lkrehi 3619 17 septic septic JJ cord-335975-m6lkrehi 3619 18 shock shock NN cord-335975-m6lkrehi 3619 19 in in IN cord-335975-m6lkrehi 3619 20 30.7 30.7 CD cord-335975-m6lkrehi 3619 21 % % NN cord-335975-m6lkrehi 3619 22 of of IN cord-335975-m6lkrehi 3619 23 cases case NNS cord-335975-m6lkrehi 3619 24 , , , cord-335975-m6lkrehi 3619 25 neurological neurological JJ cord-335975-m6lkrehi 3619 26 and and CC cord-335975-m6lkrehi 3619 27 respiratory respiratory JJ cord-335975-m6lkrehi 3619 28 distress distress NN cord-335975-m6lkrehi 3619 29 were be VBD cord-335975-m6lkrehi 3619 30 noted note VBN cord-335975-m6lkrehi 3619 31 in in IN cord-335975-m6lkrehi 3619 32 20.5 20.5 CD cord-335975-m6lkrehi 3619 33 and and CC cord-335975-m6lkrehi 3619 34 5.3 5.3 CD cord-335975-m6lkrehi 3619 35 % % NN cord-335975-m6lkrehi 3619 36 of of IN cord-335975-m6lkrehi 3619 37 cases case NNS cord-335975-m6lkrehi 3619 38 , , , cord-335975-m6lkrehi 3619 39 respectively respectively RB cord-335975-m6lkrehi 3619 40 . . . cord-335975-m6lkrehi 3620 1 RRT rrt NN cord-335975-m6lkrehi 3620 2 indications indication NNS cord-335975-m6lkrehi 3620 3 were be VBD cord-335975-m6lkrehi 3620 4 severe severe JJ cord-335975-m6lkrehi 3620 5 acidosis acidosis NN cord-335975-m6lkrehi 3620 6 in in IN cord-335975-m6lkrehi 3620 7 27 27 CD cord-335975-m6lkrehi 3620 8 % % NN cord-335975-m6lkrehi 3620 9 of of IN cord-335975-m6lkrehi 3620 10 patients patient NNS cord-335975-m6lkrehi 3620 11 , , , cord-335975-m6lkrehi 3620 12 followed follow VBN cord-335975-m6lkrehi 3620 13 by by IN cord-335975-m6lkrehi 3620 14 21 21 CD cord-335975-m6lkrehi 3620 15 % % NN cord-335975-m6lkrehi 3620 16 hyperkalaemia hyperkalaemia NN cord-335975-m6lkrehi 3620 17 , , , cord-335975-m6lkrehi 3620 18 acute acute JJ cord-335975-m6lkrehi 3620 19 pulmonary pulmonary JJ cord-335975-m6lkrehi 3620 20 edema edema NN cord-335975-m6lkrehi 3620 21 in in IN cord-335975-m6lkrehi 3620 22 13 13 CD cord-335975-m6lkrehi 3620 23 % % NN cord-335975-m6lkrehi 3620 24 , , , cord-335975-m6lkrehi 3620 25 hemodynamic hemodynamic JJ cord-335975-m6lkrehi 3620 26 instability instability NN cord-335975-m6lkrehi 3620 27 in in IN cord-335975-m6lkrehi 3620 28 patients patient NNS cord-335975-m6lkrehi 3620 29 with with IN cord-335975-m6lkrehi 3620 30 chronic chronic JJ cord-335975-m6lkrehi 3620 31 renal renal JJ cord-335975-m6lkrehi 3620 32 failure failure NN cord-335975-m6lkrehi 3620 33 in in IN cord-335975-m6lkrehi 3620 34 12 12 CD cord-335975-m6lkrehi 3620 35 % % NN cord-335975-m6lkrehi 3620 36 , , , cord-335975-m6lkrehi 3620 37 acute acute JJ cord-335975-m6lkrehi 3620 38 renal renal JJ cord-335975-m6lkrehi 3620 39 failure failure NN cord-335975-m6lkrehi 3620 40 in in IN cord-335975-m6lkrehi 3620 41 8 8 CD cord-335975-m6lkrehi 3620 42 % % NN cord-335975-m6lkrehi 3620 43 , , , cord-335975-m6lkrehi 3620 44 and and CC cord-335975-m6lkrehi 3620 45 hyperuriaemia hyperuriaemia NN cord-335975-m6lkrehi 3620 46 in in IN cord-335975-m6lkrehi 3620 47 5 5 CD cord-335975-m6lkrehi 3620 48 % % NN cord-335975-m6lkrehi 3620 49 of of IN cord-335975-m6lkrehi 3620 50 cases case NNS cord-335975-m6lkrehi 3620 51 . . . cord-335975-m6lkrehi 3621 1 The the DT cord-335975-m6lkrehi 3621 2 technique technique NN cord-335975-m6lkrehi 3621 3 chosen choose VBN cord-335975-m6lkrehi 3621 4 is be VBZ cord-335975-m6lkrehi 3621 5 conventional conventional JJ cord-335975-m6lkrehi 3621 6 intermittent intermittent JJ cord-335975-m6lkrehi 3621 7 hemodialysis hemodialysis NN cord-335975-m6lkrehi 3621 8 with with IN cord-335975-m6lkrehi 3621 9 a a DT cord-335975-m6lkrehi 3621 10 synthetic synthetic JJ cord-335975-m6lkrehi 3621 11 membrane membrane NN cord-335975-m6lkrehi 3621 12 . . . cord-335975-m6lkrehi 3622 1 The the DT cord-335975-m6lkrehi 3622 2 main main JJ cord-335975-m6lkrehi 3622 3 duration duration NN cord-335975-m6lkrehi 3622 4 of of IN cord-335975-m6lkrehi 3622 5 the the DT cord-335975-m6lkrehi 3622 6 sessions session NNS cord-335975-m6lkrehi 3622 7 was be VBD cord-335975-m6lkrehi 3622 8 2 2 CD cord-335975-m6lkrehi 3622 9 h h NN cord-335975-m6lkrehi 3622 10 06 06 CD cord-335975-m6lkrehi 3622 11 min min NNP cord-335975-m6lkrehi 3622 12 ± ± NNP cord-335975-m6lkrehi 3622 13 45 45 CD cord-335975-m6lkrehi 3622 14 mn mn NNP cord-335975-m6lkrehi 3622 15 . . . cord-335975-m6lkrehi 3623 1 Vascular vascular JJ cord-335975-m6lkrehi 3623 2 access access NN cord-335975-m6lkrehi 3623 3 was be VBD cord-335975-m6lkrehi 3623 4 a a DT cord-335975-m6lkrehi 3623 5 right right JJ cord-335975-m6lkrehi 3623 6 internal internal JJ cord-335975-m6lkrehi 3623 7 jugular jugular NN cord-335975-m6lkrehi 3623 8 catheter catheter NN cord-335975-m6lkrehi 3623 9 in in IN cord-335975-m6lkrehi 3623 10 49.7 49.7 CD cord-335975-m6lkrehi 3623 11 % % NN cord-335975-m6lkrehi 3623 12 of of IN cord-335975-m6lkrehi 3623 13 patients patient NNS cord-335975-m6lkrehi 3623 14 and and CC cord-335975-m6lkrehi 3623 15 left leave VBD cord-335975-m6lkrehi 3623 16 in in IN cord-335975-m6lkrehi 3623 17 2.5 2.5 CD cord-335975-m6lkrehi 3623 18 % % NN cord-335975-m6lkrehi 3623 19 , , , cord-335975-m6lkrehi 3623 20 right right JJ cord-335975-m6lkrehi 3623 21 femoral femoral JJ cord-335975-m6lkrehi 3623 22 catheter catheter NN cord-335975-m6lkrehi 3623 23 in in IN cord-335975-m6lkrehi 3623 24 34.8 34.8 CD cord-335975-m6lkrehi 3623 25 % % NN cord-335975-m6lkrehi 3623 26 of of IN cord-335975-m6lkrehi 3623 27 patients patient NNS cord-335975-m6lkrehi 3623 28 and and CC cord-335975-m6lkrehi 3623 29 left leave VBD cord-335975-m6lkrehi 3623 30 in in IN cord-335975-m6lkrehi 3623 31 2.4 2.4 CD cord-335975-m6lkrehi 3623 32 % % NN cord-335975-m6lkrehi 3623 33 , , , cord-335975-m6lkrehi 3623 34 arteriovenous arteriovenous JJ cord-335975-m6lkrehi 3623 35 fistula fistula NN cord-335975-m6lkrehi 3623 36 ( ( -LRB- cord-335975-m6lkrehi 3623 37 FAV FAV NNP cord-335975-m6lkrehi 3623 38 ) ) -RRB- cord-335975-m6lkrehi 3623 39 and and CC cord-335975-m6lkrehi 3623 40 a a DT cord-335975-m6lkrehi 3623 41 tunneled tunnel VBN cord-335975-m6lkrehi 3623 42 catheter catheter NN cord-335975-m6lkrehi 3623 43 in in IN cord-335975-m6lkrehi 3623 44 7.9 7.9 CD cord-335975-m6lkrehi 3623 45 and and CC cord-335975-m6lkrehi 3623 46 2.7 2.7 CD cord-335975-m6lkrehi 3623 47 % % NN cord-335975-m6lkrehi 3623 48 of of IN cord-335975-m6lkrehi 3623 49 patients patient NNS cord-335975-m6lkrehi 3623 50 . . . cord-335975-m6lkrehi 3624 1 Mortality mortality NN cord-335975-m6lkrehi 3624 2 was be VBD cord-335975-m6lkrehi 3624 3 61 61 CD cord-335975-m6lkrehi 3624 4 , , , cord-335975-m6lkrehi 3624 5 55 55 CD cord-335975-m6lkrehi 3624 6 % % NN cord-335975-m6lkrehi 3624 7 , , , cord-335975-m6lkrehi 3624 8 chronicity chronicity NN cord-335975-m6lkrehi 3624 9 progressed progress VBD cord-335975-m6lkrehi 3624 10 in in IN cord-335975-m6lkrehi 3624 11 10.25 10.25 CD cord-335975-m6lkrehi 3624 12 % % NN cord-335975-m6lkrehi 3624 13 of of IN cord-335975-m6lkrehi 3624 14 cases case NNS cord-335975-m6lkrehi 3624 15 and and CC cord-335975-m6lkrehi 3624 16 total total JJ cord-335975-m6lkrehi 3624 17 or or CC cord-335975-m6lkrehi 3624 18 partial partial JJ cord-335975-m6lkrehi 3624 19 recovery recovery NN cord-335975-m6lkrehi 3624 20 of of IN cord-335975-m6lkrehi 3624 21 normal normal JJ cord-335975-m6lkrehi 3624 22 renal renal JJ cord-335975-m6lkrehi 3624 23 function function NN cord-335975-m6lkrehi 3624 24 in in IN cord-335975-m6lkrehi 3624 25 28 28 CD cord-335975-m6lkrehi 3624 26 % % NN cord-335975-m6lkrehi 3624 27 of of IN cord-335975-m6lkrehi 3624 28 cases case NNS cord-335975-m6lkrehi 3624 29 . . . cord-335975-m6lkrehi 3625 1 Conclusion conclusion NN cord-335975-m6lkrehi 3625 2 : : : cord-335975-m6lkrehi 3625 3 we -PRON- PRP cord-335975-m6lkrehi 3625 4 have have VBP cord-335975-m6lkrehi 3625 5 a a DT cord-335975-m6lkrehi 3625 6 high high JJ cord-335975-m6lkrehi 3625 7 rate rate NN cord-335975-m6lkrehi 3625 8 of of IN cord-335975-m6lkrehi 3625 9 mortality mortality NN cord-335975-m6lkrehi 3625 10 in in IN cord-335975-m6lkrehi 3625 11 our -PRON- PRP$ cord-335975-m6lkrehi 3625 12 ICU ICU NNP cord-335975-m6lkrehi 3626 1 that that DT cord-335975-m6lkrehi 3626 2 's be VBZ cord-335975-m6lkrehi 3626 3 why why WRB cord-335975-m6lkrehi 3626 4 we -PRON- PRP cord-335975-m6lkrehi 3626 5 will will MD cord-335975-m6lkrehi 3626 6 focus focus VB cord-335975-m6lkrehi 3626 7 on on IN cord-335975-m6lkrehi 3626 8 prevention prevention NN cord-335975-m6lkrehi 3626 9 of of IN cord-335975-m6lkrehi 3626 10 risk risk NN cord-335975-m6lkrehi 3626 11 of of IN cord-335975-m6lkrehi 3626 12 renal renal JJ cord-335975-m6lkrehi 3626 13 failure failure NN cord-335975-m6lkrehi 3626 14 in in IN cord-335975-m6lkrehi 3626 15 our -PRON- PRP$ cord-335975-m6lkrehi 3626 16 patients patient NNS cord-335975-m6lkrehi 3626 17 . . . cord-335975-m6lkrehi 3627 1 Introduction introduction NN cord-335975-m6lkrehi 3627 2 : : : cord-335975-m6lkrehi 3628 1 There there EX cord-335975-m6lkrehi 3628 2 is be VBZ cord-335975-m6lkrehi 3628 3 limited limited JJ cord-335975-m6lkrehi 3628 4 information information NN cord-335975-m6lkrehi 3628 5 on on IN cord-335975-m6lkrehi 3628 6 the the DT cord-335975-m6lkrehi 3628 7 outcome outcome NN cord-335975-m6lkrehi 3628 8 of of IN cord-335975-m6lkrehi 3628 9 acute acute JJ cord-335975-m6lkrehi 3628 10 kidney kidney NN cord-335975-m6lkrehi 3628 11 injury injury NN cord-335975-m6lkrehi 3628 12 ( ( -LRB- cord-335975-m6lkrehi 3628 13 AKI AKI NNP cord-335975-m6lkrehi 3628 14 ) ) -RRB- cord-335975-m6lkrehi 3628 15 in in IN cord-335975-m6lkrehi 3628 16 patients patient NNS cord-335975-m6lkrehi 3628 17 with with IN cord-335975-m6lkrehi 3628 18 traumatic traumatic JJ cord-335975-m6lkrehi 3628 19 intracranial intracranial JJ cord-335975-m6lkrehi 3628 20 hemorrhage hemorrhage NN cord-335975-m6lkrehi 3628 21 ( ( -LRB- cord-335975-m6lkrehi 3628 22 tICH tich NN cord-335975-m6lkrehi 3628 23 ) ) -RRB- cord-335975-m6lkrehi 3628 24 . . . cord-335975-m6lkrehi 3629 1 TICH TICH NNP cord-335975-m6lkrehi 3629 2 patient patient JJ cord-335975-m6lkrehi 3629 3 with with IN cord-335975-m6lkrehi 3629 4 AKI AKI NNP cord-335975-m6lkrehi 3629 5 was be VBD cord-335975-m6lkrehi 3629 6 related relate VBN cord-335975-m6lkrehi 3629 7 high high JJ cord-335975-m6lkrehi 3629 8 mortality mortality NN cord-335975-m6lkrehi 3629 9 rate rate NN cord-335975-m6lkrehi 3629 10 . . . cord-335975-m6lkrehi 3630 1 The the DT cord-335975-m6lkrehi 3630 2 aim aim NN cord-335975-m6lkrehi 3630 3 of of IN cord-335975-m6lkrehi 3630 4 this this DT cord-335975-m6lkrehi 3630 5 study study NN cord-335975-m6lkrehi 3630 6 is be VBZ cord-335975-m6lkrehi 3630 7 to to TO cord-335975-m6lkrehi 3630 8 estimate estimate VB cord-335975-m6lkrehi 3630 9 the the DT cord-335975-m6lkrehi 3630 10 outcome outcome NN cord-335975-m6lkrehi 3630 11 using use VBG cord-335975-m6lkrehi 3630 12 different different JJ cord-335975-m6lkrehi 3630 13 renal renal JJ cord-335975-m6lkrehi 3630 14 replacement replacement NN cord-335975-m6lkrehi 3630 15 therapy therapy NN cord-335975-m6lkrehi 3630 16 on on IN cord-335975-m6lkrehi 3630 17 the the DT cord-335975-m6lkrehi 3630 18 survival survival NN cord-335975-m6lkrehi 3630 19 rate rate NN cord-335975-m6lkrehi 3630 20 and and CC cord-335975-m6lkrehi 3630 21 rate rate NN cord-335975-m6lkrehi 3630 22 of of IN cord-335975-m6lkrehi 3630 23 long long JJ cord-335975-m6lkrehi 3630 24 term term NN cord-335975-m6lkrehi 3630 25 renal renal JJ cord-335975-m6lkrehi 3630 26 - - HYPH cord-335975-m6lkrehi 3630 27 replacement replacement NN cord-335975-m6lkrehi 3630 28 therapy therapy NN cord-335975-m6lkrehi 3630 29 in in IN cord-335975-m6lkrehi 3630 30 adult adult NN cord-335975-m6lkrehi 3630 31 tICH tich DT cord-335975-m6lkrehi 3630 32 patient patient NN cord-335975-m6lkrehi 3630 33 . . . cord-335975-m6lkrehi 3631 1 Patients patient NNS cord-335975-m6lkrehi 3631 2 and and CC cord-335975-m6lkrehi 3631 3 methods method NNS cord-335975-m6lkrehi 3632 1 : : : cord-335975-m6lkrehi 3632 2 We -PRON- PRP cord-335975-m6lkrehi 3632 3 retrospectively retrospectively RB cord-335975-m6lkrehi 3632 4 identified identify VBD cord-335975-m6lkrehi 3632 5 a a DT cord-335975-m6lkrehi 3632 6 total total NN cord-335975-m6lkrehi 3632 7 of of IN cord-335975-m6lkrehi 3632 8 310 310 CD cord-335975-m6lkrehi 3632 9 tICH tich NN cord-335975-m6lkrehi 3632 10 patients patient NNS cord-335975-m6lkrehi 3632 11 with with IN cord-335975-m6lkrehi 3632 12 AKI AKI NNP cord-335975-m6lkrehi 3632 13 who who WP cord-335975-m6lkrehi 3632 14 required require VBD cord-335975-m6lkrehi 3632 15 glycerol glycerol NN cord-335975-m6lkrehi 3632 16 or or CC cord-335975-m6lkrehi 3632 17 mannitol mannitol NN cord-335975-m6lkrehi 3632 18 therapy therapy NN cord-335975-m6lkrehi 3632 19 admitted admit VBD cord-335975-m6lkrehi 3632 20 to to IN cord-335975-m6lkrehi 3632 21 the the DT cord-335975-m6lkrehi 3632 22 intensive intensive JJ cord-335975-m6lkrehi 3632 23 care care NN cord-335975-m6lkrehi 3632 24 unit unit NN cord-335975-m6lkrehi 3632 25 during during IN cord-335975-m6lkrehi 3632 26 a a DT cord-335975-m6lkrehi 3632 27 10-year 10-year CD cord-335975-m6lkrehi 3632 28 period period NN cord-335975-m6lkrehi 3632 29 ending end VBG cord-335975-m6lkrehi 3632 30 DEC DEC NNP cord-335975-m6lkrehi 3632 31 2010 2010 CD cord-335975-m6lkrehi 3632 32 from from IN cord-335975-m6lkrehi 3632 33 the the DT cord-335975-m6lkrehi 3632 34 National National NNP cord-335975-m6lkrehi 3632 35 Health Health NNP cord-335975-m6lkrehi 3632 36 Insurance Insurance NNP cord-335975-m6lkrehi 3632 37 Research Research NNP cord-335975-m6lkrehi 3632 38 Database Database NNP cord-335975-m6lkrehi 3632 39 . . . cord-335975-m6lkrehi 3633 1 Demographic demographic JJ cord-335975-m6lkrehi 3633 2 data datum NNS cord-335975-m6lkrehi 3633 3 , , , cord-335975-m6lkrehi 3633 4 severity severity NN cord-335975-m6lkrehi 3633 5 of of IN cord-335975-m6lkrehi 3633 6 tICH tich NN cord-335975-m6lkrehi 3633 7 , , , cord-335975-m6lkrehi 3633 8 medication medication NN cord-335975-m6lkrehi 3633 9 , , , cord-335975-m6lkrehi 3633 10 level level NN cord-335975-m6lkrehi 3633 11 of of IN cord-335975-m6lkrehi 3633 12 care care NN cord-335975-m6lkrehi 3633 13 , , , cord-335975-m6lkrehi 3633 14 type type NN cord-335975-m6lkrehi 3633 15 of of IN cord-335975-m6lkrehi 3633 16 head head NN cord-335975-m6lkrehi 3633 17 surgery surgery NN cord-335975-m6lkrehi 3633 18 were be VBD cord-335975-m6lkrehi 3633 19 collected collect VBN cord-335975-m6lkrehi 3633 20 . . . cord-335975-m6lkrehi 3634 1 All all DT cord-335975-m6lkrehi 3634 2 patients patient NNS cord-335975-m6lkrehi 3634 3 subjects subject NNS cord-335975-m6lkrehi 3634 4 were be VBD cord-335975-m6lkrehi 3634 5 older old JJR cord-335975-m6lkrehi 3634 6 than than IN cord-335975-m6lkrehi 3634 7 > > XX cord-335975-m6lkrehi 3634 8 18 18 CD cord-335975-m6lkrehi 3634 9 years year NNS cord-335975-m6lkrehi 3634 10 . . . cord-335975-m6lkrehi 3635 1 We -PRON- PRP cord-335975-m6lkrehi 3635 2 also also RB cord-335975-m6lkrehi 3635 3 excluded exclude VBD cord-335975-m6lkrehi 3635 4 patients patient NNS cord-335975-m6lkrehi 3635 5 diagnosed diagnose VBN cord-335975-m6lkrehi 3635 6 with with IN cord-335975-m6lkrehi 3635 7 tICH tich RB cord-335975-m6lkrehi 3635 8 before before IN cord-335975-m6lkrehi 3635 9 the the DT cord-335975-m6lkrehi 3635 10 cohort cohort NN cord-335975-m6lkrehi 3635 11 entry entry NN cord-335975-m6lkrehi 3635 12 date date NN cord-335975-m6lkrehi 3635 13 , , , cord-335975-m6lkrehi 3635 14 hemodialysis hemodialysis NN cord-335975-m6lkrehi 3635 15 before before IN cord-335975-m6lkrehi 3635 16 tICH tich DT cord-335975-m6lkrehi 3635 17 , , , cord-335975-m6lkrehi 3635 18 chronic chronic JJ cord-335975-m6lkrehi 3635 19 kidney kidney NN cord-335975-m6lkrehi 3635 20 disease disease NN cord-335975-m6lkrehi 3635 21 cancer cancer NN cord-335975-m6lkrehi 3635 22 coagulation coagulation NN cord-335975-m6lkrehi 3635 23 defects defect VBZ cord-335975-m6lkrehi 3635 24 purpura purpura NN cord-335975-m6lkrehi 3635 25 and and CC cord-335975-m6lkrehi 3635 26 other other JJ cord-335975-m6lkrehi 3635 27 hemorrhagic hemorrhagic JJ cord-335975-m6lkrehi 3635 28 conditions condition NNS cord-335975-m6lkrehi 3635 29 , , , cord-335975-m6lkrehi 3635 30 mortality mortality NN cord-335975-m6lkrehi 3635 31 mechanical mechanical JJ cord-335975-m6lkrehi 3635 32 ventilation ventilation NN cord-335975-m6lkrehi 3635 33 ischemic ischemic JJ cord-335975-m6lkrehi 3635 34 heart heart NN cord-335975-m6lkrehi 3635 35 disease disease NN cord-335975-m6lkrehi 3635 36 before before IN cord-335975-m6lkrehi 3635 37 tracking tracking NN cord-335975-m6lkrehi 3635 38 . . . cord-335975-m6lkrehi 3636 1 The the DT cord-335975-m6lkrehi 3636 2 primary primary JJ cord-335975-m6lkrehi 3636 3 outcome outcome NN cord-335975-m6lkrehi 3636 4 was be VBD cord-335975-m6lkrehi 3636 5 overall overall JJ cord-335975-m6lkrehi 3636 6 survival survival NN cord-335975-m6lkrehi 3636 7 at at IN cord-335975-m6lkrehi 3636 8 day day NN cord-335975-m6lkrehi 3636 9 30 30 CD cord-335975-m6lkrehi 3636 10 . . . cord-335975-m6lkrehi 3637 1 The the DT cord-335975-m6lkrehi 3637 2 secondary secondary JJ cord-335975-m6lkrehi 3637 3 outcome outcome NN cord-335975-m6lkrehi 3637 4 was be VBD cord-335975-m6lkrehi 3637 5 the the DT cord-335975-m6lkrehi 3637 6 rate rate NN cord-335975-m6lkrehi 3637 7 of of IN cord-335975-m6lkrehi 3637 8 long long JJ cord-335975-m6lkrehi 3637 9 term term NN cord-335975-m6lkrehi 3637 10 HD hd NN cord-335975-m6lkrehi 3637 11 therapy therapy NN cord-335975-m6lkrehi 3637 12 . . . cord-335975-m6lkrehi 3638 1 Results result NNS cord-335975-m6lkrehi 3638 2 : : : cord-335975-m6lkrehi 3639 1 A a DT cord-335975-m6lkrehi 3639 2 total total NN cord-335975-m6lkrehi 3639 3 of of IN cord-335975-m6lkrehi 3639 4 310 310 CD cord-335975-m6lkrehi 3639 5 patients patient NNS cord-335975-m6lkrehi 3639 6 were be VBD cord-335975-m6lkrehi 3639 7 enrolled enrol VBN cord-335975-m6lkrehi 3639 8 . . . cord-335975-m6lkrehi 3640 1 The the DT cord-335975-m6lkrehi 3640 2 Kaplan Kaplan NNP cord-335975-m6lkrehi 3640 3 - - HYPH cord-335975-m6lkrehi 3640 4 Meier Meier NNP cord-335975-m6lkrehi 3640 5 estimates estimate NNS cord-335975-m6lkrehi 3640 6 of of IN cord-335975-m6lkrehi 3640 7 mortality mortality NN cord-335975-m6lkrehi 3640 8 at at IN cord-335975-m6lkrehi 3640 9 day day NN cord-335975-m6lkrehi 3640 10 30 30 CD cord-335975-m6lkrehi 3640 11 did do VBD cord-335975-m6lkrehi 3640 12 not not RB cord-335975-m6lkrehi 3640 13 differ differ VB cord-335975-m6lkrehi 3640 14 significantly significantly RB cord-335975-m6lkrehi 3640 15 between between IN cord-335975-m6lkrehi 3640 16 the the DT cord-335975-m6lkrehi 3640 17 continuous continuous JJ cord-335975-m6lkrehi 3640 18 veno veno NNP cord-335975-m6lkrehi 3640 19 - - HYPH cord-335975-m6lkrehi 3640 20 venous venous JJ cord-335975-m6lkrehi 3640 21 hemofiltration hemofiltration NNP cord-335975-m6lkrehi 3640 22 ( ( -LRB- cord-335975-m6lkrehi 3640 23 CVVH CVVH NNP cord-335975-m6lkrehi 3640 24 ) ) -RRB- cord-335975-m6lkrehi 3640 25 and and CC cord-335975-m6lkrehi 3640 26 hemodialysis hemodialysis NN cord-335975-m6lkrehi 3640 27 ( ( -LRB- cord-335975-m6lkrehi 3640 28 HD HD NNP cord-335975-m6lkrehi 3640 29 ) ) -RRB- cord-335975-m6lkrehi 3640 30 strategies strategy NNS cord-335975-m6lkrehi 3640 31 + + SYM cord-335975-m6lkrehi 3640 32 5 5 CD cord-335975-m6lkrehi 3640 33 deaths death NNS cord-335975-m6lkrehi 3640 34 occurred occur VBD cord-335975-m6lkrehi 3640 35 among among IN cord-335975-m6lkrehi 3640 36 134 134 CD cord-335975-m6lkrehi 3640 37 patients patient NNS cord-335975-m6lkrehi 3640 38 receiving receive VBG cord-335975-m6lkrehi 3640 39 CVVH CVVH NNP cord-335975-m6lkrehi 3640 40 - - HYPH cord-335975-m6lkrehi 3640 41 strategy strategy NN cord-335975-m6lkrehi 3640 42 group group NN cord-335975-m6lkrehi 3640 43 and and CC cord-335975-m6lkrehi 3640 44 9 9 CD cord-335975-m6lkrehi 3640 45 deaths death NNS cord-335975-m6lkrehi 3640 46 occurred occur VBD cord-335975-m6lkrehi 3640 47 among among IN cord-335975-m6lkrehi 3640 48 176 176 CD cord-335975-m6lkrehi 3640 49 patients patient NNS cord-335975-m6lkrehi 3640 50 receiving receive VBG cord-335975-m6lkrehi 3640 51 HD hd NN cord-335975-m6lkrehi 3640 52 - - HYPH cord-335975-m6lkrehi 3640 53 strategy strategy NN cord-335975-m6lkrehi 3640 54 group group NN cord-335975-m6lkrehi 3640 55 ( ( -LRB- cord-335975-m6lkrehi 3640 56 adjusted adjust VBN cord-335975-m6lkrehi 3640 57 hazard hazard NN cord-335975-m6lkrehi 3640 58 ratio ratio NN cord-335975-m6lkrehi 3640 59 : : : cord-335975-m6lkrehi 3640 60 0.782 0.782 CD cord-335975-m6lkrehi 3640 61 , , , cord-335975-m6lkrehi 3640 62 95 95 CD cord-335975-m6lkrehi 3640 63 % % NN cord-335975-m6lkrehi 3640 64 CI CI NNP cord-335975-m6lkrehi 3640 65 0.239 0.239 CD cord-335975-m6lkrehi 3640 66 to to IN cord-335975-m6lkrehi 3640 67 2.558 2.558 CD cord-335975-m6lkrehi 3640 68 ; ; : cord-335975-m6lkrehi 3640 69 p p NN cord-335975-m6lkrehi 3640 70 = = SYM cord-335975-m6lkrehi 3640 71 0.685 0.685 CD cord-335975-m6lkrehi 3640 72 ) ) -RRB- cord-335975-m6lkrehi 3640 73 . . . cord-335975-m6lkrehi 3641 1 The the DT cord-335975-m6lkrehi 3641 2 rate rate NN cord-335975-m6lkrehi 3641 3 of of IN cord-335975-m6lkrehi 3641 4 long long JJ cord-335975-m6lkrehi 3641 5 term term NN cord-335975-m6lkrehi 3641 6 HD hd NN cord-335975-m6lkrehi 3641 7 was be VBD cord-335975-m6lkrehi 3641 8 higher high JJR cord-335975-m6lkrehi 3641 9 in in IN cord-335975-m6lkrehi 3641 10 the the DT cord-335975-m6lkrehi 3641 11 HD hd NN cord-335975-m6lkrehi 3641 12 - - HYPH cord-335975-m6lkrehi 3641 13 strategy strategy NN cord-335975-m6lkrehi 3641 14 group group NN cord-335975-m6lkrehi 3641 15 than than IN cord-335975-m6lkrehi 3641 16 in in IN cord-335975-m6lkrehi 3641 17 the the DT cord-335975-m6lkrehi 3641 18 CVVH cvvh JJ cord-335975-m6lkrehi 3641 19 - - HYPH cord-335975-m6lkrehi 3641 20 strategy strategy NN cord-335975-m6lkrehi 3641 21 group group NN cord-335975-m6lkrehi 3641 22 ( ( -LRB- cord-335975-m6lkrehi 3641 23 15.34 15.34 CD cord-335975-m6lkrehi 3641 24 vs. vs. IN cord-335975-m6lkrehi 3641 25 7.46 7.46 CD cord-335975-m6lkrehi 3641 26 % % NN cord-335975-m6lkrehi 3641 27 , , , cord-335975-m6lkrehi 3641 28 p p NN cord-335975-m6lkrehi 3641 29 = = SYM cord-335975-m6lkrehi 3641 30 0.021 0.021 CD cord-335975-m6lkrehi 3641 31 ) ) -RRB- cord-335975-m6lkrehi 3641 32 especially especially RB cord-335975-m6lkrehi 3641 33 in in IN cord-335975-m6lkrehi 3641 34 injury injury NN cord-335975-m6lkrehi 3641 35 severity severity NN cord-335975-m6lkrehi 3641 36 score score NN cord-335975-m6lkrehi 3641 37 ≥ ≥ CD cord-335975-m6lkrehi 3641 38 16 16 CD cord-335975-m6lkrehi 3641 39 group group NN cord-335975-m6lkrehi 3641 40 ( ( -LRB- cord-335975-m6lkrehi 3641 41 Table Table NNP cord-335975-m6lkrehi 3641 42 1 1 CD cord-335975-m6lkrehi 3641 43 ) ) -RRB- cord-335975-m6lkrehi 3641 44 . . . cord-335975-m6lkrehi 3642 1 Discussion discussion NN cord-335975-m6lkrehi 3642 2 : : : cord-335975-m6lkrehi 3643 1 In in IN cord-335975-m6lkrehi 3643 2 our -PRON- PRP$ cord-335975-m6lkrehi 3643 3 study study NN cord-335975-m6lkrehi 3643 4 , , , cord-335975-m6lkrehi 3643 5 tICH tich RB cord-335975-m6lkrehi 3643 6 patient patient JJ cord-335975-m6lkrehi 3643 7 with with IN cord-335975-m6lkrehi 3643 8 AKI AKI NNP cord-335975-m6lkrehi 3643 9 receving receve VBG cord-335975-m6lkrehi 3643 10 CVVH CVVH NNP cord-335975-m6lkrehi 3643 11 may may MD cord-335975-m6lkrehi 3643 12 have have VB cord-335975-m6lkrehi 3643 13 effect effect NN cord-335975-m6lkrehi 3643 14 on on IN cord-335975-m6lkrehi 3643 15 renal renal JJ cord-335975-m6lkrehi 3643 16 blood blood NN cord-335975-m6lkrehi 3643 17 flow flow NN cord-335975-m6lkrehi 3643 18 protection protection NN cord-335975-m6lkrehi 3643 19 or or CC cord-335975-m6lkrehi 3643 20 cytokine cytokine NN cord-335975-m6lkrehi 3643 21 removal removal NN cord-335975-m6lkrehi 3643 22 which which WDT cord-335975-m6lkrehi 3643 23 lower lower VBP cord-335975-m6lkrehi 3643 24 the the DT cord-335975-m6lkrehi 3643 25 rate rate NN cord-335975-m6lkrehi 3643 26 of of IN cord-335975-m6lkrehi 3643 27 long long JJ cord-335975-m6lkrehi 3643 28 term term NN cord-335975-m6lkrehi 3643 29 HD hd NN cord-335975-m6lkrehi 3643 30 . . . cord-335975-m6lkrehi 3644 1 Conclusion conclusion NN cord-335975-m6lkrehi 3644 2 : : : cord-335975-m6lkrehi 3645 1 These these DT cord-335975-m6lkrehi 3645 2 clinical clinical JJ cord-335975-m6lkrehi 3645 3 data datum NNS cord-335975-m6lkrehi 3645 4 provides provide VBZ cord-335975-m6lkrehi 3645 5 readers reader NNS cord-335975-m6lkrehi 3645 6 interventions intervention NNS cord-335975-m6lkrehi 3645 7 to to TO cord-335975-m6lkrehi 3645 8 improve improve VB cord-335975-m6lkrehi 3645 9 outcomes outcome NNS cord-335975-m6lkrehi 3645 10 in in IN cord-335975-m6lkrehi 3645 11 this this DT cord-335975-m6lkrehi 3645 12 population population NN cord-335975-m6lkrehi 3645 13 and and CC cord-335975-m6lkrehi 3645 14 future future JJ cord-335975-m6lkrehi 3645 15 study study NN cord-335975-m6lkrehi 3645 16 are be VBP cord-335975-m6lkrehi 3645 17 needed need VBN cord-335975-m6lkrehi 3645 18 to to TO cord-335975-m6lkrehi 3645 19 confirm confirm VB cord-335975-m6lkrehi 3645 20 the the DT cord-335975-m6lkrehi 3645 21 result result NN cord-335975-m6lkrehi 3645 22 . . . cord-335975-m6lkrehi 3646 1 This this DT cord-335975-m6lkrehi 3646 2 study study NN cord-335975-m6lkrehi 3646 3 highlights highlight VBZ cord-335975-m6lkrehi 3646 4 the the DT cord-335975-m6lkrehi 3646 5 importance importance NN cord-335975-m6lkrehi 3646 6 different different JJ cord-335975-m6lkrehi 3646 7 renal renal JJ cord-335975-m6lkrehi 3646 8 replecement replecement NN cord-335975-m6lkrehi 3646 9 therapy therapy NN cord-335975-m6lkrehi 3646 10 in in IN cord-335975-m6lkrehi 3646 11 the the DT cord-335975-m6lkrehi 3646 12 tICH tich NN cord-335975-m6lkrehi 3646 13 with with IN cord-335975-m6lkrehi 3646 14 AKI AKI NNP cord-335975-m6lkrehi 3646 15 population population NN cord-335975-m6lkrehi 3646 16 ( ( -LRB- cord-335975-m6lkrehi 3646 17 Table table NN cord-335975-m6lkrehi 3646 18 1 1 CD cord-335975-m6lkrehi 3646 19 ) ) -RRB- cord-335975-m6lkrehi 3646 20 . . . cord-335975-m6lkrehi 3647 1 Khaleq Khaleq NNP cord-335975-m6lkrehi 3647 2 Khalid Khalid NNP cord-335975-m6lkrehi 3647 3 1 1 CD cord-335975-m6lkrehi 3647 4 , , , cord-335975-m6lkrehi 3647 5 Hattabi Hattabi NNP cord-335975-m6lkrehi 3647 6 Khalid Khalid NNP cord-335975-m6lkrehi 3647 7 1 1 CD cord-335975-m6lkrehi 3647 8 , , , cord-335975-m6lkrehi 3648 1 Bensardi Bensardi NNP cord-335975-m6lkrehi 3648 2 Fatima Fatima NNP cord-335975-m6lkrehi 3648 3 Zahra Zahra NNP cord-335975-m6lkrehi 3648 4 1 1 CD cord-335975-m6lkrehi 3648 5 , , , cord-335975-m6lkrehi 3648 6 Bouhouri Bouhouri NNP cord-335975-m6lkrehi 3648 7 M. M. NNP cord-335975-m6lkrehi 3648 8 A A NNP cord-335975-m6lkrehi 3648 9 1 1 CD cord-335975-m6lkrehi 3648 10 , , , cord-335975-m6lkrehi 3649 1 Nciri Nciri NNP cord-335975-m6lkrehi 3649 2 A A NNP cord-335975-m6lkrehi 3649 3 1 1 CD cord-335975-m6lkrehi 3649 4 , , , cord-335975-m6lkrehi 3649 5 Hamoudi Hamoudi NNP cord-335975-m6lkrehi 3649 6 D D NNP cord-335975-m6lkrehi 3649 7 1 1 CD cord-335975-m6lkrehi 3649 8 , , , cord-335975-m6lkrehi 3649 9 Alharrar Alharrar NNP cord-335975-m6lkrehi 3649 10 R r NN cord-335975-m6lkrehi 3649 11 1 1 CD cord-335975-m6lkrehi 3649 12 Introduction introduction NN cord-335975-m6lkrehi 3649 13 : : : cord-335975-m6lkrehi 3650 1 The the DT cord-335975-m6lkrehi 3650 2 combined combined JJ cord-335975-m6lkrehi 3650 3 progress progress NN cord-335975-m6lkrehi 3650 4 of of IN cord-335975-m6lkrehi 3650 5 abdominal abdominal JJ cord-335975-m6lkrehi 3650 6 surgery surgery NN cord-335975-m6lkrehi 3650 7 and and CC cord-335975-m6lkrehi 3650 8 anesthesia anesthesia NN cord-335975-m6lkrehi 3650 9 lead lead VBP cord-335975-m6lkrehi 3650 10 to to IN cord-335975-m6lkrehi 3650 11 more more RBR cord-335975-m6lkrehi 3650 12 frequent frequent JJ cord-335975-m6lkrehi 3650 13 surgical surgical JJ cord-335975-m6lkrehi 3650 14 indications indication NNS cord-335975-m6lkrehi 3650 15 , , , cord-335975-m6lkrehi 3650 16 including include VBG cord-335975-m6lkrehi 3650 17 for for IN cord-335975-m6lkrehi 3650 18 fragile fragile JJ cord-335975-m6lkrehi 3650 19 patients patient NNS cord-335975-m6lkrehi 3650 20 or or CC cord-335975-m6lkrehi 3650 21 serious serious JJ cord-335975-m6lkrehi 3650 22 pathologiesPostoperative pathologiespostoperative JJ cord-335975-m6lkrehi 3650 23 morbidity morbidity NN cord-335975-m6lkrehi 3650 24 and and CC cord-335975-m6lkrehi 3650 25 mortality mortality NN cord-335975-m6lkrehi 3650 26 is be VBZ cord-335975-m6lkrehi 3650 27 an an DT cord-335975-m6lkrehi 3650 28 element element NN cord-335975-m6lkrehi 3650 29 that that WDT cord-335975-m6lkrehi 3650 30 requires require VBZ cord-335975-m6lkrehi 3650 31 evaluation evaluation NN cord-335975-m6lkrehi 3650 32 and and CC cord-335975-m6lkrehi 3650 33 analysis analysis NN cord-335975-m6lkrehi 3650 34 in in IN cord-335975-m6lkrehi 3650 35 surgical surgical JJ cord-335975-m6lkrehi 3650 36 resuscitation resuscitation NN cord-335975-m6lkrehi 3650 37 . . . cord-335975-m6lkrehi 3651 1 Although although IN cord-335975-m6lkrehi 3651 2 pathological pathological JJ cord-335975-m6lkrehi 3651 3 processes process NNS cord-335975-m6lkrehi 3651 4 and and CC cord-335975-m6lkrehi 3651 5 new new JJ cord-335975-m6lkrehi 3651 6 therapeutic therapeutic JJ cord-335975-m6lkrehi 3651 7 approaches approach NNS cord-335975-m6lkrehi 3651 8 in in IN cord-335975-m6lkrehi 3651 9 surgery surgery NN cord-335975-m6lkrehi 3651 10 are be VBP cord-335975-m6lkrehi 3651 11 currently currently RB cord-335975-m6lkrehi 3651 12 well well RB cord-335975-m6lkrehi 3651 13 known know VBN cord-335975-m6lkrehi 3651 14 , , , cord-335975-m6lkrehi 3651 15 data datum NNS cord-335975-m6lkrehi 3651 16 on on IN cord-335975-m6lkrehi 3651 17 risk risk NN cord-335975-m6lkrehi 3651 18 factors factor NNS cord-335975-m6lkrehi 3651 19 for for IN cord-335975-m6lkrehi 3651 20 morbidity morbidity NN cord-335975-m6lkrehi 3651 21 and and CC cord-335975-m6lkrehi 3651 22 mortality mortality NN cord-335975-m6lkrehi 3651 23 are be VBP cord-335975-m6lkrehi 3651 24 less less RBR cord-335975-m6lkrehi 3651 25 available available JJ cord-335975-m6lkrehi 3651 26 . . . cord-335975-m6lkrehi 3652 1 The the DT cord-335975-m6lkrehi 3652 2 aim aim NN cord-335975-m6lkrehi 3652 3 of of IN cord-335975-m6lkrehi 3652 4 our -PRON- PRP$ cord-335975-m6lkrehi 3652 5 work work NN cord-335975-m6lkrehi 3652 6 is be VBZ cord-335975-m6lkrehi 3652 7 to to TO cord-335975-m6lkrehi 3652 8 evaluate evaluate VB cord-335975-m6lkrehi 3652 9 the the DT cord-335975-m6lkrehi 3652 10 post post JJ cord-335975-m6lkrehi 3652 11 - - JJ cord-335975-m6lkrehi 3652 12 operative operative JJ cord-335975-m6lkrehi 3652 13 morbidity morbidity NN cord-335975-m6lkrehi 3652 14 and and CC cord-335975-m6lkrehi 3652 15 mortality mortality NN cord-335975-m6lkrehi 3652 16 rate rate NN cord-335975-m6lkrehi 3652 17 and and CC cord-335975-m6lkrehi 3652 18 to to TO cord-335975-m6lkrehi 3652 19 identify identify VB cord-335975-m6lkrehi 3652 20 the the DT cord-335975-m6lkrehi 3652 21 main main JJ cord-335975-m6lkrehi 3652 22 predictive predictive JJ cord-335975-m6lkrehi 3652 23 factors factor NNS cord-335975-m6lkrehi 3652 24 . . . cord-335975-m6lkrehi 3653 1 Patients patient NNS cord-335975-m6lkrehi 3653 2 and and CC cord-335975-m6lkrehi 3653 3 methods method NNS cord-335975-m6lkrehi 3653 4 : : : cord-335975-m6lkrehi 3653 5 A a DT cord-335975-m6lkrehi 3653 6 retrospective retrospective JJ cord-335975-m6lkrehi 3653 7 - - HYPH cord-335975-m6lkrehi 3653 8 cohort cohort NN cord-335975-m6lkrehi 3653 9 , , , cord-335975-m6lkrehi 3653 10 unicentric unicentric JJ cord-335975-m6lkrehi 3653 11 study study NN cord-335975-m6lkrehi 3653 12 that that WDT cord-335975-m6lkrehi 3653 13 included include VBD cord-335975-m6lkrehi 3653 14 all all DT cord-335975-m6lkrehi 3653 15 consecutive consecutive JJ cord-335975-m6lkrehi 3653 16 patients patient NNS cord-335975-m6lkrehi 3653 17 hospitalized hospitalize VBN cord-335975-m6lkrehi 3653 18 in in IN cord-335975-m6lkrehi 3653 19 the the DT cord-335975-m6lkrehi 3653 20 surgical surgical JJ cord-335975-m6lkrehi 3653 21 resuscitation resuscitation NN cord-335975-m6lkrehi 3653 22 department department NN cord-335975-m6lkrehi 3653 23 after after IN cord-335975-m6lkrehi 3653 24 abdominal abdominal JJ cord-335975-m6lkrehi 3653 25 surgery surgery NN cord-335975-m6lkrehi 3653 26 regardless regardless RB cord-335975-m6lkrehi 3653 27 of of IN cord-335975-m6lkrehi 3653 28 the the DT cord-335975-m6lkrehi 3653 29 operated operate VBN cord-335975-m6lkrehi 3653 30 organ organ NN cord-335975-m6lkrehi 3653 31 , , , cord-335975-m6lkrehi 3653 32 during during IN cord-335975-m6lkrehi 3653 33 3 3 CD cord-335975-m6lkrehi 3653 34 years year NNS cord-335975-m6lkrehi 3653 35 . . . cord-335975-m6lkrehi 3654 1 The the DT cord-335975-m6lkrehi 3654 2 structured structured JJ cord-335975-m6lkrehi 3654 3 sheet sheet NN cord-335975-m6lkrehi 3654 4 of of IN cord-335975-m6lkrehi 3654 5 data datum NNS cord-335975-m6lkrehi 3654 6 collection collection NN cord-335975-m6lkrehi 3654 7 included include VBD cord-335975-m6lkrehi 3654 8 more more JJR cord-335975-m6lkrehi 3654 9 than than IN cord-335975-m6lkrehi 3654 10 100 100 CD cord-335975-m6lkrehi 3654 11 items item NNS cord-335975-m6lkrehi 3654 12 on on IN cord-335975-m6lkrehi 3654 13 all all DT cord-335975-m6lkrehi 3654 14 perioperative perioperative JJ cord-335975-m6lkrehi 3654 15 data datum NNS cord-335975-m6lkrehi 3654 16 concerning concern VBG cord-335975-m6lkrehi 3654 17 the the DT cord-335975-m6lkrehi 3654 18 patient patient NN cord-335975-m6lkrehi 3654 19 , , , cord-335975-m6lkrehi 3654 20 the the DT cord-335975-m6lkrehi 3654 21 disease disease NN cord-335975-m6lkrehi 3654 22 , , , cord-335975-m6lkrehi 3654 23 and and CC cord-335975-m6lkrehi 3654 24 the the DT cord-335975-m6lkrehi 3654 25 operating operating NN cord-335975-m6lkrehi 3654 26 surgeons surgeon NNS cord-335975-m6lkrehi 3654 27 . . . cord-335975-m6lkrehi 3655 1 Postoperative postoperative JJ cord-335975-m6lkrehi 3655 2 mortality mortality NN cord-335975-m6lkrehi 3655 3 and and CC cord-335975-m6lkrehi 3655 4 morbidity morbidity NN cord-335975-m6lkrehi 3655 5 were be VBD cord-335975-m6lkrehi 3655 6 defined define VBN cord-335975-m6lkrehi 3655 7 as as IN cord-335975-m6lkrehi 3655 8 in in IN cord-335975-m6lkrehi 3655 9 - - HYPH cord-335975-m6lkrehi 3655 10 hospital hospital NN cord-335975-m6lkrehi 3655 11 death death NN cord-335975-m6lkrehi 3655 12 and and CC cord-335975-m6lkrehi 3655 13 complications complication NNS cord-335975-m6lkrehi 3655 14 . . . cord-335975-m6lkrehi 3656 1 A a DT cord-335975-m6lkrehi 3656 2 first first JJ cord-335975-m6lkrehi 3656 3 descriptive descriptive JJ cord-335975-m6lkrehi 3656 4 analysis analysis NN cord-335975-m6lkrehi 3656 5 of of IN cord-335975-m6lkrehi 3656 6 the the DT cord-335975-m6lkrehi 3656 7 various various JJ cord-335975-m6lkrehi 3656 8 parameters parameter NNS cord-335975-m6lkrehi 3656 9 collected collect VBN cord-335975-m6lkrehi 3656 10 was be VBD cord-335975-m6lkrehi 3656 11 carried carry VBN cord-335975-m6lkrehi 3656 12 out out RP cord-335975-m6lkrehi 3656 13 A a DT cord-335975-m6lkrehi 3656 14 bivariate bivariate JJ cord-335975-m6lkrehi 3656 15 analysis analysis NN cord-335975-m6lkrehi 3656 16 was be VBD cord-335975-m6lkrehi 3656 17 then then RB cord-335975-m6lkrehi 3656 18 performed perform VBN cord-335975-m6lkrehi 3656 19 to to TO cord-335975-m6lkrehi 3656 20 study study VB cord-335975-m6lkrehi 3656 21 the the DT cord-335975-m6lkrehi 3656 22 factors factor NNS cord-335975-m6lkrehi 3656 23 affecting affect VBG cord-335975-m6lkrehi 3656 24 morbidity morbidity NN cord-335975-m6lkrehi 3656 25 and and CC cord-335975-m6lkrehi 3656 26 mortality mortality NN cord-335975-m6lkrehi 3656 27 in in IN cord-335975-m6lkrehi 3656 28 digestive digestive JJ cord-335975-m6lkrehi 3656 29 surgery surgery NN cord-335975-m6lkrehi 3657 1 The the DT cord-335975-m6lkrehi 3657 2 comparison comparison NN cord-335975-m6lkrehi 3657 3 was be VBD cord-335975-m6lkrehi 3657 4 made make VBN cord-335975-m6lkrehi 3657 5 using use VBG cord-335975-m6lkrehi 3657 6 the the DT cord-335975-m6lkrehi 3657 7 student student NN cord-335975-m6lkrehi 3657 8 's 's POS cord-335975-m6lkrehi 3657 9 t t NN cord-335975-m6lkrehi 3657 10 test test NN cord-335975-m6lkrehi 3657 11 for for IN cord-335975-m6lkrehi 3657 12 quantitative quantitative JJ cord-335975-m6lkrehi 3657 13 variables variable NNS cord-335975-m6lkrehi 3657 14 and and CC cord-335975-m6lkrehi 3657 15 the the DT cord-335975-m6lkrehi 3657 16 Chi Chi NNP cord-335975-m6lkrehi 3657 17 square square NN cord-335975-m6lkrehi 3657 18 for for IN cord-335975-m6lkrehi 3657 19 the the DT cord-335975-m6lkrehi 3657 20 qualitative qualitative JJ cord-335975-m6lkrehi 3657 21 variables variable NNS cord-335975-m6lkrehi 3657 22 . . . cord-335975-m6lkrehi 3658 1 A a DT cord-335975-m6lkrehi 3658 2 difference difference NN cord-335975-m6lkrehi 3658 3 is be VBZ cord-335975-m6lkrehi 3658 4 considered consider VBN cord-335975-m6lkrehi 3658 5 significant significant JJ cord-335975-m6lkrehi 3658 6 when when WRB cord-335975-m6lkrehi 3658 7 p p NN cord-335975-m6lkrehi 3658 8 < < XX cord-335975-m6lkrehi 3658 9 0.05 0.05 CD cord-335975-m6lkrehi 3658 10 ( ( -LRB- cord-335975-m6lkrehi 3658 11 5 5 CD cord-335975-m6lkrehi 3658 12 % % NN cord-335975-m6lkrehi 3658 13 ) ) -RRB- cord-335975-m6lkrehi 3658 14 . . . cord-335975-m6lkrehi 3659 1 Results result NNS cord-335975-m6lkrehi 3659 2 : : : cord-335975-m6lkrehi 3660 1 Among among IN cord-335975-m6lkrehi 3660 2 360 360 CD cord-335975-m6lkrehi 3660 3 patients patient NNS cord-335975-m6lkrehi 3660 4 , , , cord-335975-m6lkrehi 3660 5 the the DT cord-335975-m6lkrehi 3660 6 in in IN cord-335975-m6lkrehi 3660 7 - - HYPH cord-335975-m6lkrehi 3660 8 hospital hospital NN cord-335975-m6lkrehi 3660 9 death death NN cord-335975-m6lkrehi 3660 10 rate rate NN cord-335975-m6lkrehi 3660 11 was be VBD cord-335975-m6lkrehi 3660 12 15.08 15.08 CD cord-335975-m6lkrehi 3660 13 % % NN cord-335975-m6lkrehi 3660 14 and and CC cord-335975-m6lkrehi 3660 15 the the DT cord-335975-m6lkrehi 3660 16 overall overall JJ cord-335975-m6lkrehi 3660 17 morbidity morbidity NN cord-335975-m6lkrehi 3660 18 rate rate NN cord-335975-m6lkrehi 3660 19 was be VBD cord-335975-m6lkrehi 3660 20 41.61 41.61 CD cord-335975-m6lkrehi 3660 21 % % NN cord-335975-m6lkrehi 3660 22 , , , cord-335975-m6lkrehi 3660 23 the the DT cord-335975-m6lkrehi 3660 24 mean mean JJ cord-335975-m6lkrehi 3660 25 age age NN cord-335975-m6lkrehi 3660 26 was be VBD cord-335975-m6lkrehi 3660 27 55.54 55.54 CD cord-335975-m6lkrehi 3660 28 ± ± NNP cord-335975-m6lkrehi 3660 29 15 15 CD cord-335975-m6lkrehi 3660 30 , , , cord-335975-m6lkrehi 3660 31 10 10 CD cord-335975-m6lkrehi 3660 32 years year NNS cord-335975-m6lkrehi 3660 33 with with IN cord-335975-m6lkrehi 3660 34 extreme extreme JJ cord-335975-m6lkrehi 3660 35 ages age NNS cord-335975-m6lkrehi 3660 36 of of IN cord-335975-m6lkrehi 3660 37 18 18 CD cord-335975-m6lkrehi 3660 38 years year NNS cord-335975-m6lkrehi 3660 39 and and CC cord-335975-m6lkrehi 3660 40 85 85 CD cord-335975-m6lkrehi 3660 41 years year NNS cord-335975-m6lkrehi 3660 42 with with IN cord-335975-m6lkrehi 3660 43 sex sex NN cord-335975-m6lkrehi 3660 44 ratio ratio NN cord-335975-m6lkrehi 3660 45 of of IN cord-335975-m6lkrehi 3660 46 1.01 1.01 CD cord-335975-m6lkrehi 3660 47 . . . cord-335975-m6lkrehi 3661 1 Five five CD cord-335975-m6lkrehi 3661 2 factors factor NNS cord-335975-m6lkrehi 3661 3 were be VBD cord-335975-m6lkrehi 3661 4 incriminated incriminate VBN cord-335975-m6lkrehi 3661 5 in in IN cord-335975-m6lkrehi 3661 6 post post JJ cord-335975-m6lkrehi 3661 7 : : : cord-335975-m6lkrehi 3661 8 operative operative JJ cord-335975-m6lkrehi 3661 9 mortality mortality NN cord-335975-m6lkrehi 3661 10 notably notably RB cord-335975-m6lkrehi 3661 11 : : : cord-335975-m6lkrehi 3661 12 renal renal JJ cord-335975-m6lkrehi 3661 13 failure failure NN cord-335975-m6lkrehi 3661 14 p p NN cord-335975-m6lkrehi 3661 15 = = SYM cord-335975-m6lkrehi 3661 16 0.002 0.002 CD cord-335975-m6lkrehi 3661 17 , , , cord-335975-m6lkrehi 3661 18 duration duration NN cord-335975-m6lkrehi 3661 19 of of IN cord-335975-m6lkrehi 3661 20 stay stay NN cord-335975-m6lkrehi 3661 21 p p NN cord-335975-m6lkrehi 3661 22 = = SYM cord-335975-m6lkrehi 3661 23 0.001 0.001 CD cord-335975-m6lkrehi 3661 24 , , , cord-335975-m6lkrehi 3661 25 parenteral parenteral JJ cord-335975-m6lkrehi 3661 26 nutrition nutrition NN cord-335975-m6lkrehi 3661 27 p p NN cord-335975-m6lkrehi 3661 28 = = SYM cord-335975-m6lkrehi 3661 29 0.047 0.047 CD cord-335975-m6lkrehi 3661 30 , , , cord-335975-m6lkrehi 3661 31 long long JJ cord-335975-m6lkrehi 3661 32 duration duration NN cord-335975-m6lkrehi 3661 33 of of IN cord-335975-m6lkrehi 3661 34 intubation intubation NN cord-335975-m6lkrehi 3661 35 p p NN cord-335975-m6lkrehi 3661 36 = = SYM cord-335975-m6lkrehi 3661 37 0.001 0.001 CD cord-335975-m6lkrehi 3661 38 , , , cord-335975-m6lkrehi 3661 39 perioperative perioperative JJ cord-335975-m6lkrehi 3661 40 blood blood NN cord-335975-m6lkrehi 3661 41 transfusion transfusion NN cord-335975-m6lkrehi 3661 42 p p NN cord-335975-m6lkrehi 3661 43 = = SYM cord-335975-m6lkrehi 3661 44 0.001 0.001 CD cord-335975-m6lkrehi 3661 45 . . . cord-335975-m6lkrehi 3662 1 Three three CD cord-335975-m6lkrehi 3662 2 factors factor NNS cord-335975-m6lkrehi 3662 3 influencing influence VBG cord-335975-m6lkrehi 3662 4 morbidity morbidity NN cord-335975-m6lkrehi 3662 5 were be VBD cord-335975-m6lkrehi 3662 6 found find VBN cord-335975-m6lkrehi 3662 7 : : : cord-335975-m6lkrehi 3662 8 duration duration NN cord-335975-m6lkrehi 3662 9 of of IN cord-335975-m6lkrehi 3662 10 stay stay NN cord-335975-m6lkrehi 3662 11 p p NN cord-335975-m6lkrehi 3662 12 = = SYM cord-335975-m6lkrehi 3662 13 0.003 0.003 CD cord-335975-m6lkrehi 3662 14 , , , cord-335975-m6lkrehi 3662 15 Parenteral Parenteral NNP cord-335975-m6lkrehi 3662 16 nutrition nutrition NN cord-335975-m6lkrehi 3662 17 p p NN cord-335975-m6lkrehi 3662 18 = = SYM cord-335975-m6lkrehi 3662 19 0.018 0.018 CD cord-335975-m6lkrehi 3662 20 , , , cord-335975-m6lkrehi 3662 21 long long JJ cord-335975-m6lkrehi 3662 22 duration duration NN cord-335975-m6lkrehi 3662 23 of of IN cord-335975-m6lkrehi 3662 24 intubation intubation NN cord-335975-m6lkrehi 3662 25 p p NN cord-335975-m6lkrehi 3662 26 = = SYM cord-335975-m6lkrehi 3662 27 0.0001 0.0001 CD cord-335975-m6lkrehi 3662 28 . . . cord-335975-m6lkrehi 3663 1 Conclusion conclusion NN cord-335975-m6lkrehi 3663 2 : : : cord-335975-m6lkrehi 3664 1 Knowledge knowledge NN cord-335975-m6lkrehi 3664 2 of of IN cord-335975-m6lkrehi 3664 3 the the DT cord-335975-m6lkrehi 3664 4 true true JJ cord-335975-m6lkrehi 3664 5 frequency frequency NN cord-335975-m6lkrehi 3664 6 of of IN cord-335975-m6lkrehi 3664 7 both both DT cord-335975-m6lkrehi 3664 8 mortality mortality NN cord-335975-m6lkrehi 3664 9 and and CC cord-335975-m6lkrehi 3664 10 morbidity morbidity NN cord-335975-m6lkrehi 3664 11 is be VBZ cord-335975-m6lkrehi 3664 12 crucial crucial JJ cord-335975-m6lkrehi 3664 13 in in IN cord-335975-m6lkrehi 3664 14 planning plan VBG cord-335975-m6lkrehi 3664 15 health health NN cord-335975-m6lkrehi 3664 16 care care NN cord-335975-m6lkrehi 3664 17 and and CC cord-335975-m6lkrehi 3664 18 research research NN cord-335975-m6lkrehi 3664 19 and and CC cord-335975-m6lkrehi 3664 20 identifying identify VBG cord-335975-m6lkrehi 3664 21 risk risk NN cord-335975-m6lkrehi 3664 22 factors factor NNS cord-335975-m6lkrehi 3664 23 . . . cord-335975-m6lkrehi 3665 1 Introduction introduction NN cord-335975-m6lkrehi 3665 2 : : : cord-335975-m6lkrehi 3665 3 Tools tool NNS cord-335975-m6lkrehi 3665 4 to to TO cord-335975-m6lkrehi 3665 5 quantify quantify VB cord-335975-m6lkrehi 3665 6 and and CC cord-335975-m6lkrehi 3665 7 assess assess VB cord-335975-m6lkrehi 3665 8 bowl bowl NN cord-335975-m6lkrehi 3665 9 management management NN cord-335975-m6lkrehi 3665 10 in in IN cord-335975-m6lkrehi 3665 11 critically critically RB cord-335975-m6lkrehi 3665 12 ill ill JJ cord-335975-m6lkrehi 3665 13 are be VBP cord-335975-m6lkrehi 3665 14 still still RB cord-335975-m6lkrehi 3665 15 very very RB cord-335975-m6lkrehi 3665 16 limited limited JJ cord-335975-m6lkrehi 3665 17 and and CC cord-335975-m6lkrehi 3665 18 often often RB cord-335975-m6lkrehi 3665 19 over over RB cord-335975-m6lkrehi 3665 20 - - HYPH cord-335975-m6lkrehi 3665 21 looked look VBN cord-335975-m6lkrehi 3665 22 . . . cord-335975-m6lkrehi 3666 1 With with IN cord-335975-m6lkrehi 3666 2 the the DT cord-335975-m6lkrehi 3666 3 primary primary JJ cord-335975-m6lkrehi 3666 4 Fig Fig NNP cord-335975-m6lkrehi 3666 5 . . . cord-335975-m6lkrehi 3666 6 1 1 CD cord-335975-m6lkrehi 3666 7 Filter filter NN cord-335975-m6lkrehi 3666 8 's 's POS cord-335975-m6lkrehi 3666 9 lifespan lifespan NN cord-335975-m6lkrehi 3666 10 concern concern NN cord-335975-m6lkrehi 3666 11 of of IN cord-335975-m6lkrehi 3666 12 optimizing optimize VBG cord-335975-m6lkrehi 3666 13 patients patient NNS cord-335975-m6lkrehi 3666 14 to to TO cord-335975-m6lkrehi 3666 15 preserve preserve VB cord-335975-m6lkrehi 3666 16 life life NN cord-335975-m6lkrehi 3666 17 , , , cord-335975-m6lkrehi 3666 18 the the DT cord-335975-m6lkrehi 3666 19 problem problem NN cord-335975-m6lkrehi 3666 20 of of IN cord-335975-m6lkrehi 3666 21 bowel bowel NN cord-335975-m6lkrehi 3666 22 care care NN cord-335975-m6lkrehi 3666 23 has have VBZ cord-335975-m6lkrehi 3666 24 been be VBN cord-335975-m6lkrehi 3666 25 given give VBN cord-335975-m6lkrehi 3666 26 less less JJR cord-335975-m6lkrehi 3666 27 priority priority NN cord-335975-m6lkrehi 3666 28 . . . cord-335975-m6lkrehi 3667 1 The the DT cord-335975-m6lkrehi 3667 2 aim aim NN cord-335975-m6lkrehi 3667 3 of of IN cord-335975-m6lkrehi 3667 4 this this DT cord-335975-m6lkrehi 3667 5 study study NN cord-335975-m6lkrehi 3667 6 was be VBD cord-335975-m6lkrehi 3667 7 to to TO cord-335975-m6lkrehi 3667 8 use use VB cord-335975-m6lkrehi 3667 9 ultrasonographic ultrasonographic JJ cord-335975-m6lkrehi 3667 10 measurements measurement NNS cord-335975-m6lkrehi 3667 11 of of IN cord-335975-m6lkrehi 3667 12 gastric gastric JJ cord-335975-m6lkrehi 3667 13 emptying emptying NN cord-335975-m6lkrehi 3667 14 in in IN cord-335975-m6lkrehi 3667 15 the the DT cord-335975-m6lkrehi 3667 16 critically critically RB cord-335975-m6lkrehi 3667 17 ill ill JJ cord-335975-m6lkrehi 3667 18 as as IN cord-335975-m6lkrehi 3667 19 a a DT cord-335975-m6lkrehi 3667 20 tool tool NN cord-335975-m6lkrehi 3667 21 of of IN cord-335975-m6lkrehi 3667 22 measurement measurement NN cord-335975-m6lkrehi 3667 23 of of IN cord-335975-m6lkrehi 3667 24 the the DT cord-335975-m6lkrehi 3667 25 impact impact NN cord-335975-m6lkrehi 3667 26 of of IN cord-335975-m6lkrehi 3667 27 different different JJ cord-335975-m6lkrehi 3667 28 specific specific JJ cord-335975-m6lkrehi 3667 29 factors factor NNS cord-335975-m6lkrehi 3667 30 of of IN cord-335975-m6lkrehi 3667 31 ICU ICU NNP cord-335975-m6lkrehi 3667 32 stay stay VBP cord-335975-m6lkrehi 3667 33 on on IN cord-335975-m6lkrehi 3667 34 bowl bowl NN cord-335975-m6lkrehi 3667 35 emptying emptying NN cord-335975-m6lkrehi 3667 36 . . . cord-335975-m6lkrehi 3668 1 Patients patient NNS cord-335975-m6lkrehi 3668 2 and and CC cord-335975-m6lkrehi 3668 3 methods method NNS cord-335975-m6lkrehi 3668 4 : : : cord-335975-m6lkrehi 3668 5 This this DT cord-335975-m6lkrehi 3668 6 is be VBZ cord-335975-m6lkrehi 3668 7 a a DT cord-335975-m6lkrehi 3668 8 prospective prospective JJ cord-335975-m6lkrehi 3668 9 study study NN cord-335975-m6lkrehi 3668 10 conducted conduct VBN cord-335975-m6lkrehi 3668 11 in in IN cord-335975-m6lkrehi 3668 12 an an DT cord-335975-m6lkrehi 3668 13 Intensive intensive JJ cord-335975-m6lkrehi 3668 14 care care NN cord-335975-m6lkrehi 3668 15 unit unit NN cord-335975-m6lkrehi 3668 16 for for IN cord-335975-m6lkrehi 3668 17 1 1 CD cord-335975-m6lkrehi 3668 18 months month NNS cord-335975-m6lkrehi 3668 19 . . . cord-335975-m6lkrehi 3669 1 It -PRON- PRP cord-335975-m6lkrehi 3669 2 included include VBD cord-335975-m6lkrehi 3669 3 32 32 CD cord-335975-m6lkrehi 3669 4 patients patient NNS cord-335975-m6lkrehi 3669 5 . . . cord-335975-m6lkrehi 3670 1 Ultrasonic ultrasonic JJ cord-335975-m6lkrehi 3670 2 imaging imaging NN cord-335975-m6lkrehi 3670 3 of of IN cord-335975-m6lkrehi 3670 4 antral antral JJ cord-335975-m6lkrehi 3670 5 sections section NNS cord-335975-m6lkrehi 3670 6 was be VBD cord-335975-m6lkrehi 3670 7 undertaken undertake VBN cord-335975-m6lkrehi 3670 8 every every DT cord-335975-m6lkrehi 3670 9 15 15 CD cord-335975-m6lkrehi 3670 10 min min NN cord-335975-m6lkrehi 3670 11 for for IN cord-335975-m6lkrehi 3670 12 the the DT cord-335975-m6lkrehi 3670 13 first first JJ cord-335975-m6lkrehi 3670 14 1 1 CD cord-335975-m6lkrehi 3670 15 h h NN cord-335975-m6lkrehi 3670 16 and and CC cord-335975-m6lkrehi 3670 17 every every DT cord-335975-m6lkrehi 3670 18 30 30 CD cord-335975-m6lkrehi 3670 19 min min NN cord-335975-m6lkrehi 3670 20 thereafter thereafter RB cord-335975-m6lkrehi 3670 21 until until IN cord-335975-m6lkrehi 3670 22 total total JJ cord-335975-m6lkrehi 3670 23 emptying emptying NN cord-335975-m6lkrehi 3670 24 . . . cord-335975-m6lkrehi 3671 1 Correlation correlation NN cord-335975-m6lkrehi 3671 2 analyses analysis NNS cord-335975-m6lkrehi 3671 3 were be VBD cord-335975-m6lkrehi 3671 4 calculated calculate VBN cord-335975-m6lkrehi 3671 5 , , , cord-335975-m6lkrehi 3671 6 applying apply VBG cord-335975-m6lkrehi 3671 7 an an DT cord-335975-m6lkrehi 3671 8 adjusted adjust VBN cord-335975-m6lkrehi 3671 9 significance significance NN cord-335975-m6lkrehi 3671 10 level level NN cord-335975-m6lkrehi 3671 11 ( ( -LRB- cord-335975-m6lkrehi 3671 12 Pb Pb NNP cord-335975-m6lkrehi 3671 13 < < XX cord-335975-m6lkrehi 3671 14 .0125 .0125 . cord-335975-m6lkrehi 3671 15 ) ) -RRB- cord-335975-m6lkrehi 3671 16 to to TO cord-335975-m6lkrehi 3671 17 correct correct VB cord-335975-m6lkrehi 3671 18 for for IN cord-335975-m6lkrehi 3671 19 multiple multiple JJ cord-335975-m6lkrehi 3671 20 testing testing NN cord-335975-m6lkrehi 3671 21 . . . cord-335975-m6lkrehi 3672 1 Results result NNS cord-335975-m6lkrehi 3672 2 : : : cord-335975-m6lkrehi 3673 1 All all DT cord-335975-m6lkrehi 3673 2 our -PRON- PRP$ cord-335975-m6lkrehi 3673 3 patients patient NNS cord-335975-m6lkrehi 3673 4 were be VBD cord-335975-m6lkrehi 3673 5 above above IN cord-335975-m6lkrehi 3673 6 the the DT cord-335975-m6lkrehi 3673 7 age age NN cord-335975-m6lkrehi 3673 8 of of IN cord-335975-m6lkrehi 3673 9 18 18 CD cord-335975-m6lkrehi 3673 10 . . . cord-335975-m6lkrehi 3674 1 The the DT cord-335975-m6lkrehi 3674 2 median median NN cord-335975-m6lkrehi 3674 3 of of IN cord-335975-m6lkrehi 3674 4 age age NN cord-335975-m6lkrehi 3674 5 was be VBD cord-335975-m6lkrehi 3674 6 years year NNS cord-335975-m6lkrehi 3674 7 old old JJ cord-335975-m6lkrehi 3674 8 31 31 CD cord-335975-m6lkrehi 3674 9 . . . cord-335975-m6lkrehi 3675 1 19 19 CD cord-335975-m6lkrehi 3675 2 of of IN cord-335975-m6lkrehi 3675 3 our -PRON- PRP$ cord-335975-m6lkrehi 3675 4 patients patient NNS cord-335975-m6lkrehi 3675 5 were be VBD cord-335975-m6lkrehi 3675 6 male male JJ cord-335975-m6lkrehi 3675 7 and and CC cord-335975-m6lkrehi 3675 8 13 13 CD cord-335975-m6lkrehi 3675 9 were be VBD cord-335975-m6lkrehi 3675 10 female female JJ cord-335975-m6lkrehi 3675 11 . . . cord-335975-m6lkrehi 3676 1 The the DT cord-335975-m6lkrehi 3676 2 total total JJ cord-335975-m6lkrehi 3676 3 emptying empty VBG cord-335975-m6lkrehi 3676 4 median median JJ cord-335975-m6lkrehi 3676 5 time time NN cord-335975-m6lkrehi 3676 6 was be VBD cord-335975-m6lkrehi 3676 7 273 273 CD cord-335975-m6lkrehi 3676 8 ± ± NNP cord-335975-m6lkrehi 3676 9 21 21 CD cord-335975-m6lkrehi 3676 10 min min NN cord-335975-m6lkrehi 3676 11 . . . cord-335975-m6lkrehi 3677 1 Significant significant JJ cord-335975-m6lkrehi 3677 2 correlation correlation NN cord-335975-m6lkrehi 3677 3 was be VBD cord-335975-m6lkrehi 3677 4 observed observe VBN cord-335975-m6lkrehi 3677 5 between between IN cord-335975-m6lkrehi 3677 6 length length NN cord-335975-m6lkrehi 3677 7 of of IN cord-335975-m6lkrehi 3677 8 stay stay NN cord-335975-m6lkrehi 3677 9 and and CC cord-335975-m6lkrehi 3677 10 delay delay VB cord-335975-m6lkrehi 3677 11 in in IN cord-335975-m6lkrehi 3677 12 bowl bowl NN cord-335975-m6lkrehi 3677 13 emptying emptying NN cord-335975-m6lkrehi 3677 14 . . . cord-335975-m6lkrehi 3678 1 Mechanical mechanical JJ cord-335975-m6lkrehi 3678 2 ventilation ventilation NN cord-335975-m6lkrehi 3678 3 had have VBD cord-335975-m6lkrehi 3678 4 also also RB cord-335975-m6lkrehi 3678 5 significant significant JJ cord-335975-m6lkrehi 3678 6 relation relation NN cord-335975-m6lkrehi 3678 7 with with IN cord-335975-m6lkrehi 3678 8 slower slow JJR cord-335975-m6lkrehi 3678 9 bowl bowl NN cord-335975-m6lkrehi 3678 10 progression progression NN cord-335975-m6lkrehi 3678 11 and and CC cord-335975-m6lkrehi 3678 12 gastric gastric JJ cord-335975-m6lkrehi 3678 13 emptying emptying NN cord-335975-m6lkrehi 3678 14 . . . cord-335975-m6lkrehi 3679 1 Patients patient NNS cord-335975-m6lkrehi 3679 2 in in IN cord-335975-m6lkrehi 3679 3 septic septic JJ cord-335975-m6lkrehi 3679 4 shock shock NN cord-335975-m6lkrehi 3679 5 had have VBD cord-335975-m6lkrehi 3679 6 tendencies tendency NNS cord-335975-m6lkrehi 3679 7 to to TO cord-335975-m6lkrehi 3679 8 earlier early RBR cord-335975-m6lkrehi 3679 9 delayed delay VBN cord-335975-m6lkrehi 3679 10 bowl bowl NN cord-335975-m6lkrehi 3679 11 emptying empty VBG cord-335975-m6lkrehi 3679 12 compare compare VBP cord-335975-m6lkrehi 3679 13 to to IN cord-335975-m6lkrehi 3679 14 others other NNS cord-335975-m6lkrehi 3679 15 patients patient NNS cord-335975-m6lkrehi 3679 16 included include VBN cord-335975-m6lkrehi 3679 17 in in IN cord-335975-m6lkrehi 3679 18 our -PRON- PRP$ cord-335975-m6lkrehi 3679 19 study study NN cord-335975-m6lkrehi 3679 20 . . . cord-335975-m6lkrehi 3680 1 Conclusion conclusion NN cord-335975-m6lkrehi 3680 2 : : : cord-335975-m6lkrehi 3681 1 The the DT cord-335975-m6lkrehi 3681 2 study study NN cord-335975-m6lkrehi 3681 3 we -PRON- PRP cord-335975-m6lkrehi 3681 4 conducted conduct VBD cord-335975-m6lkrehi 3681 5 is be VBZ cord-335975-m6lkrehi 3681 6 a a DT cord-335975-m6lkrehi 3681 7 pilot pilot NN cord-335975-m6lkrehi 3681 8 study study NN cord-335975-m6lkrehi 3681 9 . . . cord-335975-m6lkrehi 3682 1 Further further JJ cord-335975-m6lkrehi 3682 2 studies study NNS cord-335975-m6lkrehi 3682 3 should should MD cord-335975-m6lkrehi 3682 4 be be VB cord-335975-m6lkrehi 3682 5 conducted conduct VBN cord-335975-m6lkrehi 3682 6 and and CC cord-335975-m6lkrehi 3682 7 unltrasonografic unltrasonografic JJ cord-335975-m6lkrehi 3682 8 gastric gastric JJ cord-335975-m6lkrehi 3682 9 assessment assessment NN cord-335975-m6lkrehi 3682 10 could could MD cord-335975-m6lkrehi 3682 11 be be VB cord-335975-m6lkrehi 3682 12 standardized standardize VBN cord-335975-m6lkrehi 3682 13 in in IN cord-335975-m6lkrehi 3682 14 protocols protocol NNS cord-335975-m6lkrehi 3682 15 to to TO cord-335975-m6lkrehi 3682 16 assess assess VB cord-335975-m6lkrehi 3682 17 clinical clinical JJ cord-335975-m6lkrehi 3682 18 decision decision NN cord-335975-m6lkrehi 3682 19 making making NN cord-335975-m6lkrehi 3682 20 and and CC cord-335975-m6lkrehi 3682 21 improve improve VB cord-335975-m6lkrehi 3682 22 nutrition nutrition NN cord-335975-m6lkrehi 3682 23 and and CC cord-335975-m6lkrehi 3682 24 bowl bowl NN cord-335975-m6lkrehi 3682 25 management management NN cord-335975-m6lkrehi 3682 26 in in IN cord-335975-m6lkrehi 3682 27 ICU ICU NNP cord-335975-m6lkrehi 3682 28 patients patient NNS cord-335975-m6lkrehi 3682 29 . . . cord-335975-m6lkrehi 3683 1 Introduction introduction NN cord-335975-m6lkrehi 3683 2 : : : cord-335975-m6lkrehi 3684 1 Enteral enteral JJ cord-335975-m6lkrehi 3684 2 nutrition nutrition NN cord-335975-m6lkrehi 3684 3 , , , cord-335975-m6lkrehi 3684 4 via via IN cord-335975-m6lkrehi 3684 5 a a DT cord-335975-m6lkrehi 3684 6 feeding feeding NN cord-335975-m6lkrehi 3684 7 tube tube NN cord-335975-m6lkrehi 3684 8 , , , cord-335975-m6lkrehi 3684 9 is be VBZ cord-335975-m6lkrehi 3684 10 often often RB cord-335975-m6lkrehi 3684 11 used use VBN cord-335975-m6lkrehi 3684 12 in in IN cord-335975-m6lkrehi 3684 13 Intensive intensive JJ cord-335975-m6lkrehi 3684 14 care care NN cord-335975-m6lkrehi 3684 15 units unit NNS cord-335975-m6lkrehi 3684 16 ( ( -LRB- cord-335975-m6lkrehi 3684 17 ICU ICU NNP cord-335975-m6lkrehi 3684 18 ) ) -RRB- cord-335975-m6lkrehi 3684 19 to to TO cord-335975-m6lkrehi 3684 20 supply supply VB cord-335975-m6lkrehi 3684 21 artificial artificial JJ cord-335975-m6lkrehi 3684 22 nutrition nutrition NN cord-335975-m6lkrehi 3684 23 to to TO cord-335975-m6lkrehi 3684 24 critically critically RB cord-335975-m6lkrehi 3684 25 ill ill VB cord-335975-m6lkrehi 3684 26 patients patient NNS cord-335975-m6lkrehi 3684 27 . . . cord-335975-m6lkrehi 3685 1 The the DT cord-335975-m6lkrehi 3685 2 feeding feeding NN cord-335975-m6lkrehi 3685 3 tube tube NN cord-335975-m6lkrehi 3685 4 is be VBZ cord-335975-m6lkrehi 3685 5 also also RB cord-335975-m6lkrehi 3685 6 commonly commonly RB cord-335975-m6lkrehi 3685 7 used use VBN cord-335975-m6lkrehi 3685 8 to to TO cord-335975-m6lkrehi 3685 9 administrate administrate VB cord-335975-m6lkrehi 3685 10 drug drug NN cord-335975-m6lkrehi 3685 11 therapy therapy NN cord-335975-m6lkrehi 3685 12 as as RB cord-335975-m6lkrehi 3685 13 well well RB cord-335975-m6lkrehi 3685 14 . . . cord-335975-m6lkrehi 3686 1 However however RB cord-335975-m6lkrehi 3686 2 , , , cord-335975-m6lkrehi 3686 3 there there EX cord-335975-m6lkrehi 3686 4 is be VBZ cord-335975-m6lkrehi 3686 5 a a DT cord-335975-m6lkrehi 3686 6 lack lack NN cord-335975-m6lkrehi 3686 7 of of IN cord-335975-m6lkrehi 3686 8 knowledge knowledge NN cord-335975-m6lkrehi 3686 9 of of IN cord-335975-m6lkrehi 3686 10 the the DT cord-335975-m6lkrehi 3686 11 nurses nurse NNS cord-335975-m6lkrehi 3686 12 about about IN cord-335975-m6lkrehi 3686 13 this this DT cord-335975-m6lkrehi 3686 14 way way NN cord-335975-m6lkrehi 3686 15 of of IN cord-335975-m6lkrehi 3686 16 administration administration NN cord-335975-m6lkrehi 3686 17 . . . cord-335975-m6lkrehi 3687 1 This this DT cord-335975-m6lkrehi 3687 2 could could MD cord-335975-m6lkrehi 3687 3 be be VB cord-335975-m6lkrehi 3687 4 a a DT cord-335975-m6lkrehi 3687 5 potential potential JJ cord-335975-m6lkrehi 3687 6 source source NN cord-335975-m6lkrehi 3687 7 of of IN cord-335975-m6lkrehi 3687 8 medicine medicine NN cord-335975-m6lkrehi 3687 9 - - HYPH cord-335975-m6lkrehi 3687 10 related relate VBN cord-335975-m6lkrehi 3687 11 illness illness NN cord-335975-m6lkrehi 3687 12 . . . cord-335975-m6lkrehi 3688 1 The the DT cord-335975-m6lkrehi 3688 2 purpose purpose NN cord-335975-m6lkrehi 3688 3 of of IN cord-335975-m6lkrehi 3688 4 this this DT cord-335975-m6lkrehi 3688 5 study study NN cord-335975-m6lkrehi 3688 6 was be VBD cord-335975-m6lkrehi 3688 7 first first RB cord-335975-m6lkrehi 3688 8 , , , cord-335975-m6lkrehi 3688 9 to to TO cord-335975-m6lkrehi 3688 10 evaluate evaluate VB cord-335975-m6lkrehi 3688 11 the the DT cord-335975-m6lkrehi 3688 12 nurse nurse NN cord-335975-m6lkrehi 3688 13 's 's POS cord-335975-m6lkrehi 3688 14 knowledge knowledge NN cord-335975-m6lkrehi 3688 15 on on IN cord-335975-m6lkrehi 3688 16 enteral enteral JJ cord-335975-m6lkrehi 3688 17 drug drug NNP cord-335975-m6lkrehi 3688 18 administration administration NN cord-335975-m6lkrehi 3688 19 , , , cord-335975-m6lkrehi 3688 20 and and CC cord-335975-m6lkrehi 3688 21 second second RB cord-335975-m6lkrehi 3688 22 , , , cord-335975-m6lkrehi 3688 23 to to TO cord-335975-m6lkrehi 3688 24 observe observe VB cord-335975-m6lkrehi 3688 25 nurses nurse NNS cord-335975-m6lkrehi 3688 26 and and CC cord-335975-m6lkrehi 3688 27 to to TO cord-335975-m6lkrehi 3688 28 evaluate evaluate VB cord-335975-m6lkrehi 3688 29 the the DT cord-335975-m6lkrehi 3688 30 adequacy adequacy NN cord-335975-m6lkrehi 3688 31 of of IN cord-335975-m6lkrehi 3688 32 their -PRON- PRP$ cord-335975-m6lkrehi 3688 33 practices practice NNS cord-335975-m6lkrehi 3688 34 with with IN cord-335975-m6lkrehi 3688 35 guidelines guideline NNS cord-335975-m6lkrehi 3688 36 , , , cord-335975-m6lkrehi 3688 37 and and CC cord-335975-m6lkrehi 3688 38 to to TO cord-335975-m6lkrehi 3688 39 report report VB cord-335975-m6lkrehi 3688 40 medication medication NN cord-335975-m6lkrehi 3688 41 - - HYPH cord-335975-m6lkrehi 3688 42 administration administration NN cord-335975-m6lkrehi 3688 43 errors error NNS cord-335975-m6lkrehi 3688 44 . . . cord-335975-m6lkrehi 3689 1 Patients patient NNS cord-335975-m6lkrehi 3689 2 and and CC cord-335975-m6lkrehi 3689 3 methods method NNS cord-335975-m6lkrehi 3689 4 : : : cord-335975-m6lkrehi 3689 5 This this DT cord-335975-m6lkrehi 3689 6 prospective prospective JJ cord-335975-m6lkrehi 3689 7 study study NN cord-335975-m6lkrehi 3689 8 using use VBG cord-335975-m6lkrehi 3689 9 the the DT cord-335975-m6lkrehi 3689 10 observation observation NN cord-335975-m6lkrehi 3689 11 technique technique NN cord-335975-m6lkrehi 3689 12 was be VBD cord-335975-m6lkrehi 3689 13 conducted conduct VBN cord-335975-m6lkrehi 3689 14 in in IN cord-335975-m6lkrehi 3689 15 2 2 CD cord-335975-m6lkrehi 3689 16 ICU ICU NNP cord-335975-m6lkrehi 3689 17 ( ( -LRB- cord-335975-m6lkrehi 3689 18 one one CD cord-335975-m6lkrehi 3689 19 medical medical JJ cord-335975-m6lkrehi 3689 20 and and CC cord-335975-m6lkrehi 3689 21 one one CD cord-335975-m6lkrehi 3689 22 surgical surgical NN cord-335975-m6lkrehi 3689 23 ) ) -RRB- cord-335975-m6lkrehi 3689 24 . . . cord-335975-m6lkrehi 3690 1 First first RB cord-335975-m6lkrehi 3690 2 , , , cord-335975-m6lkrehi 3690 3 a a DT cord-335975-m6lkrehi 3690 4 knowledge knowledge NN cord-335975-m6lkrehi 3690 5 and and CC cord-335975-m6lkrehi 3690 6 practice practice NN cord-335975-m6lkrehi 3690 7 questionnaire questionnaire NN cord-335975-m6lkrehi 3690 8 regarding regard VBG cord-335975-m6lkrehi 3690 9 drug drug NN cord-335975-m6lkrehi 3690 10 administration administration NN cord-335975-m6lkrehi 3690 11 trough trough NN cord-335975-m6lkrehi 3690 12 enteral enteral JJ cord-335975-m6lkrehi 3690 13 feeding feed VBG cord-335975-m6lkrehi 3690 14 tube tube NN cord-335975-m6lkrehi 3690 15 was be VBD cord-335975-m6lkrehi 3690 16 filled fill VBN cord-335975-m6lkrehi 3690 17 by by IN cord-335975-m6lkrehi 3690 18 each each DT cord-335975-m6lkrehi 3690 19 intensivist intensivist NN cord-335975-m6lkrehi 3690 20 nurse nurse NN cord-335975-m6lkrehi 3690 21 . . . cord-335975-m6lkrehi 3691 1 Secondly secondly RB cord-335975-m6lkrehi 3691 2 , , , cord-335975-m6lkrehi 3691 3 Pharmacist pharmacist NN cord-335975-m6lkrehi 3691 4 performed perform VBD cord-335975-m6lkrehi 3691 5 observations observation NNS cord-335975-m6lkrehi 3691 6 of of IN cord-335975-m6lkrehi 3691 7 nurses nurse NNS cord-335975-m6lkrehi 3691 8 during during IN cord-335975-m6lkrehi 3691 9 preparation preparation NN cord-335975-m6lkrehi 3691 10 and and CC cord-335975-m6lkrehi 3691 11 administration administration NN cord-335975-m6lkrehi 3691 12 of of IN cord-335975-m6lkrehi 3691 13 medications medication NNS cord-335975-m6lkrehi 3691 14 . . . cord-335975-m6lkrehi 3692 1 These these DT cord-335975-m6lkrehi 3692 2 practices practice NNS cord-335975-m6lkrehi 3692 3 were be VBD cord-335975-m6lkrehi 3692 4 compared compare VBN cord-335975-m6lkrehi 3692 5 with with IN cord-335975-m6lkrehi 3692 6 the the DT cord-335975-m6lkrehi 3692 7 original original JJ cord-335975-m6lkrehi 3692 8 medical medical JJ cord-335975-m6lkrehi 3692 9 prescription prescription NN cord-335975-m6lkrehi 3692 10 and and CC cord-335975-m6lkrehi 3692 11 with with IN cord-335975-m6lkrehi 3692 12 the the DT cord-335975-m6lkrehi 3692 13 data datum NNS cord-335975-m6lkrehi 3692 14 available available JJ cord-335975-m6lkrehi 3692 15 in in IN cord-335975-m6lkrehi 3692 16 the the DT cord-335975-m6lkrehi 3692 17 literature literature NN cord-335975-m6lkrehi 3692 18 . . . cord-335975-m6lkrehi 3693 1 Results result NNS cord-335975-m6lkrehi 3693 2 : : : cord-335975-m6lkrehi 3693 3 60 60 CD cord-335975-m6lkrehi 3693 4 questionnaires questionnaire NNS cord-335975-m6lkrehi 3693 5 were be VBD cord-335975-m6lkrehi 3693 6 returned return VBN cord-335975-m6lkrehi 3693 7 . . . cord-335975-m6lkrehi 3694 1 48 48 CD cord-335975-m6lkrehi 3694 2 nurses nurse NNS cord-335975-m6lkrehi 3694 3 evaluated evaluate VBD cord-335975-m6lkrehi 3694 4 their -PRON- PRP$ cord-335975-m6lkrehi 3694 5 knowledge knowledge NN cord-335975-m6lkrehi 3694 6 as as IN cord-335975-m6lkrehi 3694 7 medium medium NN cord-335975-m6lkrehi 3694 8 and and CC cord-335975-m6lkrehi 3694 9 9 9 CD cord-335975-m6lkrehi 3694 10 as as RB cord-335975-m6lkrehi 3694 11 inadequate inadequate JJ cord-335975-m6lkrehi 3694 12 . . . cord-335975-m6lkrehi 3695 1 There there EX cord-335975-m6lkrehi 3695 2 was be VBD cord-335975-m6lkrehi 3695 3 a a DT cord-335975-m6lkrehi 3695 4 lack lack NN cord-335975-m6lkrehi 3695 5 of of IN cord-335975-m6lkrehi 3695 6 knowledge knowledge NN cord-335975-m6lkrehi 3695 7 on on IN cord-335975-m6lkrehi 3695 8 the the DT cord-335975-m6lkrehi 3695 9 type type NN cord-335975-m6lkrehi 3695 10 of of IN cord-335975-m6lkrehi 3695 11 drugs drug NNS cord-335975-m6lkrehi 3695 12 which which WDT cord-335975-m6lkrehi 3695 13 can can MD cord-335975-m6lkrehi 3695 14 be be VB cord-335975-m6lkrehi 3695 15 used use VBN cord-335975-m6lkrehi 3695 16 by by IN cord-335975-m6lkrehi 3695 17 feeding feed VBG cord-335975-m6lkrehi 3695 18 tube tube NN cord-335975-m6lkrehi 3695 19 ( ( -LRB- cord-335975-m6lkrehi 3695 20 65 65 CD cord-335975-m6lkrehi 3695 21 wrong wrong JJ cord-335975-m6lkrehi 3695 22 responses response NNS cord-335975-m6lkrehi 3695 23 ) ) -RRB- cord-335975-m6lkrehi 3695 24 . . . cord-335975-m6lkrehi 3696 1 30 30 CD cord-335975-m6lkrehi 3696 2 nurses nurse NNS cord-335975-m6lkrehi 3696 3 and and CC cord-335975-m6lkrehi 3696 4 71 71 CD cord-335975-m6lkrehi 3696 5 different different JJ cord-335975-m6lkrehi 3696 6 drugs drug NNS cord-335975-m6lkrehi 3696 7 were be VBD cord-335975-m6lkrehi 3696 8 observed observe VBN cord-335975-m6lkrehi 3696 9 during during IN cord-335975-m6lkrehi 3696 10 the the DT cord-335975-m6lkrehi 3696 11 drug drug NN cord-335975-m6lkrehi 3696 12 administration administration NN cord-335975-m6lkrehi 3696 13 phase phase NN cord-335975-m6lkrehi 3696 14 . . . cord-335975-m6lkrehi 3697 1 No no DT cord-335975-m6lkrehi 3697 2 administration administration NN cord-335975-m6lkrehi 3697 3 totally totally RB cord-335975-m6lkrehi 3697 4 complied comply VBD cord-335975-m6lkrehi 3697 5 with with IN cord-335975-m6lkrehi 3697 6 our -PRON- PRP$ cord-335975-m6lkrehi 3697 7 institutional institutional JJ cord-335975-m6lkrehi 3697 8 protocol protocol NN cord-335975-m6lkrehi 3697 9 , , , cord-335975-m6lkrehi 3697 10 particularly particularly RB cord-335975-m6lkrehi 3697 11 the the DT cord-335975-m6lkrehi 3697 12 crush crush NN cord-335975-m6lkrehi 3697 13 of of IN cord-335975-m6lkrehi 3697 14 tablets tablet NNS cord-335975-m6lkrehi 3697 15 . . . cord-335975-m6lkrehi 3698 1 When when WRB cord-335975-m6lkrehi 3698 2 a a DT cord-335975-m6lkrehi 3698 3 tablet tablet NN cord-335975-m6lkrehi 3698 4 was be VBD cord-335975-m6lkrehi 3698 5 crushed crush VBN cord-335975-m6lkrehi 3698 6 , , , cord-335975-m6lkrehi 3698 7 in in IN cord-335975-m6lkrehi 3698 8 31 31 CD cord-335975-m6lkrehi 3698 9 % % NN cord-335975-m6lkrehi 3698 10 an an DT cord-335975-m6lkrehi 3698 11 alternative alternative JJ cord-335975-m6lkrehi 3698 12 formulation formulation NN cord-335975-m6lkrehi 3698 13 ( ( -LRB- cord-335975-m6lkrehi 3698 14 in in IN cord-335975-m6lkrehi 3698 15 syrup syrup NN cord-335975-m6lkrehi 3698 16 for for IN cord-335975-m6lkrehi 3698 17 example example NN cord-335975-m6lkrehi 3698 18 ) ) -RRB- cord-335975-m6lkrehi 3698 19 existed exist VBD cord-335975-m6lkrehi 3698 20 . . . cord-335975-m6lkrehi 3699 1 The the DT cord-335975-m6lkrehi 3699 2 correct correct JJ cord-335975-m6lkrehi 3699 3 administration administration NN cord-335975-m6lkrehi 3699 4 of of IN cord-335975-m6lkrehi 3699 5 drugs drug NNS cord-335975-m6lkrehi 3699 6 in in IN cord-335975-m6lkrehi 3699 7 feeding feed VBG cord-335975-m6lkrehi 3699 8 tubes tube NNS cord-335975-m6lkrehi 3699 9 is be VBZ cord-335975-m6lkrehi 3699 10 important important JJ cord-335975-m6lkrehi 3699 11 and and CC cord-335975-m6lkrehi 3699 12 represents represent VBZ cord-335975-m6lkrehi 3699 13 a a DT cord-335975-m6lkrehi 3699 14 challenge challenge NN cord-335975-m6lkrehi 3699 15 in in IN cord-335975-m6lkrehi 3699 16 ICU ICU NNP cord-335975-m6lkrehi 3699 17 . . . cord-335975-m6lkrehi 3700 1 Firstly firstly RB cord-335975-m6lkrehi 3700 2 , , , cord-335975-m6lkrehi 3700 3 crushed crushed JJ cord-335975-m6lkrehi 3700 4 tablets tablet NNS cord-335975-m6lkrehi 3700 5 is be VBZ cord-335975-m6lkrehi 3700 6 the the DT cord-335975-m6lkrehi 3700 7 most most RBS cord-335975-m6lkrehi 3700 8 frequent frequent JJ cord-335975-m6lkrehi 3700 9 cause cause NN cord-335975-m6lkrehi 3700 10 of of IN cord-335975-m6lkrehi 3700 11 obstruction obstruction NN cord-335975-m6lkrehi 3700 12 of of IN cord-335975-m6lkrehi 3700 13 feeding feed VBG cord-335975-m6lkrehi 3700 14 tubes tube NNS cord-335975-m6lkrehi 3700 15 which which WDT cord-335975-m6lkrehi 3700 16 have have VBP cord-335975-m6lkrehi 3700 17 to to TO cord-335975-m6lkrehi 3700 18 be be VB cord-335975-m6lkrehi 3700 19 changed change VBN cord-335975-m6lkrehi 3700 20 + + CC cord-335975-m6lkrehi 3700 21 secondly secondly RB cord-335975-m6lkrehi 3700 22 , , , cord-335975-m6lkrehi 3700 23 crushed crushed JJ cord-335975-m6lkrehi 3700 24 tablets tablet NNS cord-335975-m6lkrehi 3700 25 destroys destroy VBZ cord-335975-m6lkrehi 3700 26 the the DT cord-335975-m6lkrehi 3700 27 controlled control VBN cord-335975-m6lkrehi 3700 28 release release NN cord-335975-m6lkrehi 3700 29 of of IN cord-335975-m6lkrehi 3700 30 enteric enteric JJ cord-335975-m6lkrehi 3700 31 coated coat VBN cord-335975-m6lkrehi 3700 32 dosage dosage NN cord-335975-m6lkrehi 3700 33 forms form NNS cord-335975-m6lkrehi 3700 34 , , , cord-335975-m6lkrehi 3700 35 resulting result VBG cord-335975-m6lkrehi 3700 36 in in IN cord-335975-m6lkrehi 3700 37 a a DT cord-335975-m6lkrehi 3700 38 higher high JJR cord-335975-m6lkrehi 3700 39 or or CC cord-335975-m6lkrehi 3700 40 a a DT cord-335975-m6lkrehi 3700 41 lower low JJR cord-335975-m6lkrehi 3700 42 initial initial JJ cord-335975-m6lkrehi 3700 43 blood blood NN cord-335975-m6lkrehi 3700 44 level level NN cord-335975-m6lkrehi 3700 45 . . . cord-335975-m6lkrehi 3701 1 We -PRON- PRP cord-335975-m6lkrehi 3701 2 have have VBP cord-335975-m6lkrehi 3701 3 to to TO cord-335975-m6lkrehi 3701 4 train train VB cord-335975-m6lkrehi 3701 5 nurses nurse NNS cord-335975-m6lkrehi 3701 6 for for IN cord-335975-m6lkrehi 3701 7 drug drug NN cord-335975-m6lkrehi 3701 8 administration administration NN cord-335975-m6lkrehi 3701 9 by by IN cord-335975-m6lkrehi 3701 10 feeding feed VBG cord-335975-m6lkrehi 3701 11 tube tube NN cord-335975-m6lkrehi 3701 12 . . . cord-335975-m6lkrehi 3702 1 On on IN cord-335975-m6lkrehi 3702 2 their -PRON- PRP$ cord-335975-m6lkrehi 3702 3 daily daily JJ cord-335975-m6lkrehi 3702 4 ward ward NN cord-335975-m6lkrehi 3702 5 , , , cord-335975-m6lkrehi 3702 6 the the DT cord-335975-m6lkrehi 3702 7 pharmacist pharmacist NN cord-335975-m6lkrehi 3702 8 should should MD cord-335975-m6lkrehi 3702 9 improve improve VB cord-335975-m6lkrehi 3702 10 the the DT cord-335975-m6lkrehi 3702 11 choice choice NN cord-335975-m6lkrehi 3702 12 of of IN cord-335975-m6lkrehi 3702 13 medication medication NN cord-335975-m6lkrehi 3702 14 's 's POS cord-335975-m6lkrehi 3702 15 forms form NNS cord-335975-m6lkrehi 3702 16 . . . cord-335975-m6lkrehi 3703 1 Introduction introduction NN cord-335975-m6lkrehi 3703 2 : : : cord-335975-m6lkrehi 3704 1 Acute acute JJ cord-335975-m6lkrehi 3704 2 variceal variceal NN cord-335975-m6lkrehi 3704 3 hemorrhage hemorrhage NN cord-335975-m6lkrehi 3704 4 ( ( -LRB- cord-335975-m6lkrehi 3704 5 AVH AVH NNP cord-335975-m6lkrehi 3704 6 ) ) -RRB- cord-335975-m6lkrehi 3704 7 is be VBZ cord-335975-m6lkrehi 3704 8 a a DT cord-335975-m6lkrehi 3704 9 severe severe JJ cord-335975-m6lkrehi 3704 10 complication complication NN cord-335975-m6lkrehi 3704 11 of of IN cord-335975-m6lkrehi 3704 12 portal portal JJ cord-335975-m6lkrehi 3704 13 hypertension hypertension NN cord-335975-m6lkrehi 3704 14 . . . cord-335975-m6lkrehi 3705 1 In in IN cord-335975-m6lkrehi 3705 2 addition addition NN cord-335975-m6lkrehi 3705 3 , , , cord-335975-m6lkrehi 3705 4 the the DT cord-335975-m6lkrehi 3705 5 variceal variceal JJ cord-335975-m6lkrehi 3705 6 bleeding bleeding NN cord-335975-m6lkrehi 3705 7 is be VBZ cord-335975-m6lkrehi 3705 8 still still RB cord-335975-m6lkrehi 3705 9 the the DT cord-335975-m6lkrehi 3705 10 most most RBS cord-335975-m6lkrehi 3705 11 common common JJ cord-335975-m6lkrehi 3705 12 lethal lethal JJ cord-335975-m6lkrehi 3705 13 complication complication NN cord-335975-m6lkrehi 3705 14 of of IN cord-335975-m6lkrehi 3705 15 cirrhosis cirrhosis NN cord-335975-m6lkrehi 3705 16 . . . cord-335975-m6lkrehi 3706 1 The the DT cord-335975-m6lkrehi 3706 2 most most RBS cord-335975-m6lkrehi 3706 3 effective effective JJ cord-335975-m6lkrehi 3706 4 modality modality NN cord-335975-m6lkrehi 3706 5 of of IN cord-335975-m6lkrehi 3706 6 treating treat VBG cord-335975-m6lkrehi 3706 7 is be VBZ cord-335975-m6lkrehi 3706 8 based base VBN cord-335975-m6lkrehi 3706 9 on on IN cord-335975-m6lkrehi 3706 10 resuscitation resuscitation NN cord-335975-m6lkrehi 3706 11 combined combine VBN cord-335975-m6lkrehi 3706 12 with with IN cord-335975-m6lkrehi 3706 13 the the DT cord-335975-m6lkrehi 3706 14 endoscopic endoscopic JJ cord-335975-m6lkrehi 3706 15 variceal variceal NN cord-335975-m6lkrehi 3706 16 band band NN cord-335975-m6lkrehi 3706 17 ligation ligation NN cord-335975-m6lkrehi 3706 18 . . . cord-335975-m6lkrehi 3707 1 The the DT cord-335975-m6lkrehi 3707 2 purpose purpose NN cord-335975-m6lkrehi 3707 3 of of IN cord-335975-m6lkrehi 3707 4 this this DT cord-335975-m6lkrehi 3707 5 preliminary preliminary JJ cord-335975-m6lkrehi 3707 6 study study NN cord-335975-m6lkrehi 3707 7 was be VBD cord-335975-m6lkrehi 3707 8 to to TO cord-335975-m6lkrehi 3707 9 find find VB cord-335975-m6lkrehi 3707 10 the the DT cord-335975-m6lkrehi 3707 11 factors factor NNS cord-335975-m6lkrehi 3707 12 associated associate VBN cord-335975-m6lkrehi 3707 13 with with IN cord-335975-m6lkrehi 3707 14 poor poor JJ cord-335975-m6lkrehi 3707 15 prognosis prognosis NN cord-335975-m6lkrehi 3707 16 of of IN cord-335975-m6lkrehi 3707 17 AVH AVH NNP cord-335975-m6lkrehi 3707 18 in in IN cord-335975-m6lkrehi 3707 19 cirrhotic cirrhotic JJ cord-335975-m6lkrehi 3707 20 patients patient NNS cord-335975-m6lkrehi 3707 21 . . . cord-335975-m6lkrehi 3708 1 Patients patient NNS cord-335975-m6lkrehi 3708 2 and and CC cord-335975-m6lkrehi 3708 3 methods method NNS cord-335975-m6lkrehi 3708 4 : : : cord-335975-m6lkrehi 3708 5 This this DT cord-335975-m6lkrehi 3708 6 is be VBZ cord-335975-m6lkrehi 3708 7 a a DT cord-335975-m6lkrehi 3708 8 retrospective retrospective JJ cord-335975-m6lkrehi 3708 9 study study NN cord-335975-m6lkrehi 3708 10 , , , cord-335975-m6lkrehi 3708 11 spread spread VBD cord-335975-m6lkrehi 3708 12 over over IN cord-335975-m6lkrehi 3708 13 12 12 CD cord-335975-m6lkrehi 3708 14 months month NNS cord-335975-m6lkrehi 3708 15 between between IN cord-335975-m6lkrehi 3708 16 January January NNP cord-335975-m6lkrehi 3708 17 2016 2016 CD cord-335975-m6lkrehi 3708 18 and and CC cord-335975-m6lkrehi 3708 19 December December NNP cord-335975-m6lkrehi 3708 20 2016 2016 CD cord-335975-m6lkrehi 3708 21 . . . cord-335975-m6lkrehi 3709 1 Are be VBP cord-335975-m6lkrehi 3709 2 included include VBN cord-335975-m6lkrehi 3709 3 all all DT cord-335975-m6lkrehi 3709 4 consecutive consecutive JJ cord-335975-m6lkrehi 3709 5 patients patient NNS cord-335975-m6lkrehi 3709 6 with with IN cord-335975-m6lkrehi 3709 7 liver liver NN cord-335975-m6lkrehi 3709 8 cirrhosis cirrhosis NN cord-335975-m6lkrehi 3709 9 hospitalized hospitalize VBN cord-335975-m6lkrehi 3709 10 for for IN cord-335975-m6lkrehi 3709 11 variceal variceal NN cord-335975-m6lkrehi 3709 12 bleeding bleeding NN cord-335975-m6lkrehi 3709 13 . . . cord-335975-m6lkrehi 3710 1 We -PRON- PRP cord-335975-m6lkrehi 3710 2 exploited exploit VBD cord-335975-m6lkrehi 3710 3 the the DT cord-335975-m6lkrehi 3710 4 medical medical JJ cord-335975-m6lkrehi 3710 5 records record NNS cord-335975-m6lkrehi 3710 6 to to TO cord-335975-m6lkrehi 3710 7 identify identify VB cord-335975-m6lkrehi 3710 8 the the DT cord-335975-m6lkrehi 3710 9 clinical clinical JJ cord-335975-m6lkrehi 3710 10 , , , cord-335975-m6lkrehi 3710 11 biological biological JJ cord-335975-m6lkrehi 3710 12 and and CC cord-335975-m6lkrehi 3710 13 endoscopic endoscopic JJ cord-335975-m6lkrehi 3710 14 parameters parameter NNS cord-335975-m6lkrehi 3710 15 . . . cord-335975-m6lkrehi 3711 1 Results result NNS cord-335975-m6lkrehi 3711 2 : : : cord-335975-m6lkrehi 3712 1 A a DT cord-335975-m6lkrehi 3712 2 total total NN cord-335975-m6lkrehi 3712 3 of of IN cord-335975-m6lkrehi 3712 4 30 30 CD cord-335975-m6lkrehi 3712 5 patients patient NNS cord-335975-m6lkrehi 3712 6 hospitalized hospitalize VBN cord-335975-m6lkrehi 3712 7 for for IN cord-335975-m6lkrehi 3712 8 AVH AVH NNP cord-335975-m6lkrehi 3712 9 occurred occur VBD cord-335975-m6lkrehi 3712 10 during during IN cord-335975-m6lkrehi 3712 11 the the DT cord-335975-m6lkrehi 3712 12 study study NN cord-335975-m6lkrehi 3712 13 period period NN cord-335975-m6lkrehi 3712 14 . . . cord-335975-m6lkrehi 3713 1 The the DT cord-335975-m6lkrehi 3713 2 mean mean JJ cord-335975-m6lkrehi 3713 3 age age NN cord-335975-m6lkrehi 3713 4 at at IN cord-335975-m6lkrehi 3713 5 admission admission NN cord-335975-m6lkrehi 3713 6 was be VBD cord-335975-m6lkrehi 3713 7 60 60 CD cord-335975-m6lkrehi 3713 8 years year NNS cord-335975-m6lkrehi 3713 9 , , , cord-335975-m6lkrehi 3713 10 and and CC cord-335975-m6lkrehi 3713 11 12 12 CD cord-335975-m6lkrehi 3713 12 are be VBP cord-335975-m6lkrehi 3713 13 female female JJ cord-335975-m6lkrehi 3713 14 . . . cord-335975-m6lkrehi 3714 1 Cirrhosis cirrhosis NN cord-335975-m6lkrehi 3714 2 was be VBD cord-335975-m6lkrehi 3714 3 post post JJ cord-335975-m6lkrehi 3714 4 viral viral JJ cord-335975-m6lkrehi 3714 5 in in IN cord-335975-m6lkrehi 3714 6 30 30 CD cord-335975-m6lkrehi 3714 7 % % NN cord-335975-m6lkrehi 3714 8 of of IN cord-335975-m6lkrehi 3714 9 cases case NNS cord-335975-m6lkrehi 3714 10 . . . cord-335975-m6lkrehi 3715 1 Patients patient NNS cord-335975-m6lkrehi 3715 2 were be VBD cord-335975-m6lkrehi 3715 3 classified classify VBN cord-335975-m6lkrehi 3715 4 as as IN cord-335975-m6lkrehi 3715 5 Child child NN cord-335975-m6lkrehi 3715 6 - - HYPH cord-335975-m6lkrehi 3715 7 Pugh Pugh NNP cord-335975-m6lkrehi 3715 8 C C NNP cord-335975-m6lkrehi 3715 9 in in IN cord-335975-m6lkrehi 3715 10 40 40 CD cord-335975-m6lkrehi 3715 11 % % NN cord-335975-m6lkrehi 3715 12 of of IN cord-335975-m6lkrehi 3715 13 cases case NNS cord-335975-m6lkrehi 3715 14 . . . cord-335975-m6lkrehi 3716 1 The the DT cord-335975-m6lkrehi 3716 2 median median JJ cord-335975-m6lkrehi 3716 3 presenting present VBG cord-335975-m6lkrehi 3716 4 model model NN cord-335975-m6lkrehi 3716 5 for for IN cord-335975-m6lkrehi 3716 6 end end JJ cord-335975-m6lkrehi 3716 7 stage stage NN cord-335975-m6lkrehi 3716 8 liver liver NN cord-335975-m6lkrehi 3716 9 disease disease NN cord-335975-m6lkrehi 3716 10 ( ( -LRB- cord-335975-m6lkrehi 3716 11 MELD MELD NNP cord-335975-m6lkrehi 3716 12 ) ) -RRB- cord-335975-m6lkrehi 3716 13 and and CC cord-335975-m6lkrehi 3716 14 CLIF CLIF NNP cord-335975-m6lkrehi 3716 15 SOFA SOFA NNP cord-335975-m6lkrehi 3716 16 Were be VBD cord-335975-m6lkrehi 3716 17 respectively respectively RB cord-335975-m6lkrehi 3716 18 17 17 CD cord-335975-m6lkrehi 3716 19 and and CC cord-335975-m6lkrehi 3716 20 8.4 8.4 CD cord-335975-m6lkrehi 3716 21 . . . cord-335975-m6lkrehi 3717 1 Twelve twelve CD cord-335975-m6lkrehi 3717 2 ( ( -LRB- cord-335975-m6lkrehi 3717 3 12 12 CD cord-335975-m6lkrehi 3717 4 ) ) -RRB- cord-335975-m6lkrehi 3717 5 patients patient NNS cord-335975-m6lkrehi 3717 6 received receive VBD cord-335975-m6lkrehi 3717 7 beta beta NN cord-335975-m6lkrehi 3717 8 - - HYPH cord-335975-m6lkrehi 3717 9 blockers blocker NNS cord-335975-m6lkrehi 3717 10 and and CC cord-335975-m6lkrehi 3717 11 15 15 CD cord-335975-m6lkrehi 3717 12 have have VBP cord-335975-m6lkrehi 3717 13 required require VBN cord-335975-m6lkrehi 3717 14 at at RB cord-335975-m6lkrehi 3717 15 least least RBS cord-335975-m6lkrehi 3717 16 one one CD cord-335975-m6lkrehi 3717 17 endoscopic endoscopic JJ cord-335975-m6lkrehi 3717 18 variceal variceal NN cord-335975-m6lkrehi 3717 19 band band NN cord-335975-m6lkrehi 3717 20 ligation ligation NN cord-335975-m6lkrehi 3717 21 at at IN cord-335975-m6lkrehi 3717 22 the the DT cord-335975-m6lkrehi 3717 23 time time NN cord-335975-m6lkrehi 3717 24 of of IN cord-335975-m6lkrehi 3717 25 the the DT cord-335975-m6lkrehi 3717 26 bleeding bleeding JJ cord-335975-m6lkrehi 3717 27 episode episode NN cord-335975-m6lkrehi 3717 28 . . . cord-335975-m6lkrehi 3718 1 In in IN cord-335975-m6lkrehi 3718 2 the the DT cord-335975-m6lkrehi 3718 3 acute acute JJ cord-335975-m6lkrehi 3718 4 phase phase NN cord-335975-m6lkrehi 3718 5 , , , cord-335975-m6lkrehi 3718 6 pharmacological pharmacological JJ cord-335975-m6lkrehi 3718 7 treatment treatment NN cord-335975-m6lkrehi 3718 8 based base VBN cord-335975-m6lkrehi 3718 9 on on IN cord-335975-m6lkrehi 3718 10 vasopressor vasopressor NN cord-335975-m6lkrehi 3718 11 ( ( -LRB- cord-335975-m6lkrehi 3718 12 sandostatin sandostatin NNP cord-335975-m6lkrehi 3718 13 ) ) -RRB- cord-335975-m6lkrehi 3718 14 ) ) -RRB- cord-335975-m6lkrehi 3718 15 was be VBD cord-335975-m6lkrehi 3718 16 instituted institute VBN cord-335975-m6lkrehi 3718 17 in in IN cord-335975-m6lkrehi 3718 18 all all DT cord-335975-m6lkrehi 3718 19 cases case NNS cord-335975-m6lkrehi 3718 20 and and CC cord-335975-m6lkrehi 3718 21 combining combine VBG cord-335975-m6lkrehi 3718 22 with with IN cord-335975-m6lkrehi 3718 23 antibiotic antibiotic JJ cord-335975-m6lkrehi 3718 24 prophylaxis prophylaxis NN cord-335975-m6lkrehi 3718 25 ( ( -LRB- cord-335975-m6lkrehi 3718 26 C3 C3 NNP cord-335975-m6lkrehi 3718 27 G g NN cord-335975-m6lkrehi 3718 28 or or CC cord-335975-m6lkrehi 3718 29 fluoroquinolone fluoroquinolone NN cord-335975-m6lkrehi 3718 30 ) ) -RRB- cord-335975-m6lkrehi 3718 31 in in IN cord-335975-m6lkrehi 3718 32 26 26 CD cord-335975-m6lkrehi 3718 33 cases case NNS cord-335975-m6lkrehi 3718 34 . . . cord-335975-m6lkrehi 3719 1 In in IN cord-335975-m6lkrehi 3719 2 8 8 CD cord-335975-m6lkrehi 3719 3 cases case NNS cord-335975-m6lkrehi 3719 4 the the DT cord-335975-m6lkrehi 3719 5 endoscopy endoscopy NN cord-335975-m6lkrehi 3719 6 was be VBD cord-335975-m6lkrehi 3719 7 made make VBN cord-335975-m6lkrehi 3719 8 within within IN cord-335975-m6lkrehi 3719 9 12 12 CD cord-335975-m6lkrehi 3719 10 h h NN cord-335975-m6lkrehi 3719 11 , , , cord-335975-m6lkrehi 3719 12 Active active JJ cord-335975-m6lkrehi 3719 13 bleeding bleed VBG cord-335975-m6lkrehi 3719 14 at at IN cord-335975-m6lkrehi 3719 15 endoscopy endoscopy NN cord-335975-m6lkrehi 3719 16 was be VBD cord-335975-m6lkrehi 3719 17 observed observe VBN cord-335975-m6lkrehi 3719 18 in in IN cord-335975-m6lkrehi 3719 19 20 20 CD cord-335975-m6lkrehi 3719 20 patients patient NNS cord-335975-m6lkrehi 3719 21 . . . cord-335975-m6lkrehi 3720 1 Esophageal esophageal JJ cord-335975-m6lkrehi 3720 2 avarices avarice NNS cord-335975-m6lkrehi 3720 3 ( ( -LRB- cord-335975-m6lkrehi 3720 4 OV OV NNP cord-335975-m6lkrehi 3720 5 ) ) -RRB- cord-335975-m6lkrehi 3720 6 were be VBD cord-335975-m6lkrehi 3720 7 grade grade NN cord-335975-m6lkrehi 3720 8 I -PRON- PRP cord-335975-m6lkrehi 3720 9 ( ( -LRB- cord-335975-m6lkrehi 3720 10 2 2 CD cord-335975-m6lkrehi 3720 11 patients patient NNS cord-335975-m6lkrehi 3720 12 ) ) -RRB- cord-335975-m6lkrehi 3720 13 grade grade NN cord-335975-m6lkrehi 3720 14 II II NNP cord-335975-m6lkrehi 3720 15 ( ( -LRB- cord-335975-m6lkrehi 3720 16 10 10 CD cord-335975-m6lkrehi 3720 17 patients patient NNS cord-335975-m6lkrehi 3720 18 ) ) -RRB- cord-335975-m6lkrehi 3720 19 and and CC cord-335975-m6lkrehi 3720 20 grade grade NN cord-335975-m6lkrehi 3720 21 III iii CD cord-335975-m6lkrehi 3720 22 ( ( -LRB- cord-335975-m6lkrehi 3720 23 18 18 CD cord-335975-m6lkrehi 3720 24 patients patient NNS cord-335975-m6lkrehi 3720 25 ) ) -RRB- cord-335975-m6lkrehi 3720 26 . . . cord-335975-m6lkrehi 3721 1 The the DT cord-335975-m6lkrehi 3721 2 eradication eradication NN cord-335975-m6lkrehi 3721 3 of of IN cord-335975-m6lkrehi 3721 4 varices varix NNS cord-335975-m6lkrehi 3721 5 was be VBD cord-335975-m6lkrehi 3721 6 obtained obtain VBN cord-335975-m6lkrehi 3721 7 in in IN cord-335975-m6lkrehi 3721 8 23 23 CD cord-335975-m6lkrehi 3721 9 patients patient NNS cord-335975-m6lkrehi 3721 10 ( ( -LRB- cord-335975-m6lkrehi 3721 11 76.6 76.6 CD cord-335975-m6lkrehi 3721 12 % % NN cord-335975-m6lkrehi 3721 13 percentage percentage NN cord-335975-m6lkrehi 3721 14 of of IN cord-335975-m6lkrehi 3721 15 the the DT cord-335975-m6lkrehi 3721 16 cases case NNS cord-335975-m6lkrehi 3721 17 ) ) -RRB- cord-335975-m6lkrehi 3721 18 . . . cord-335975-m6lkrehi 3722 1 The the DT cord-335975-m6lkrehi 3722 2 variceal variceal JJ cord-335975-m6lkrehi 3722 3 bleeding bleeding NN cord-335975-m6lkrehi 3722 4 recurred recur VBD cord-335975-m6lkrehi 3722 5 in in IN cord-335975-m6lkrehi 3722 6 9 9 CD cord-335975-m6lkrehi 3722 7 of of IN cord-335975-m6lkrehi 3722 8 patients patient NNS cord-335975-m6lkrehi 3722 9 ( ( -LRB- cord-335975-m6lkrehi 3722 10 30%of 30%of JJ cord-335975-m6lkrehi 3722 11 cases case NNS cord-335975-m6lkrehi 3722 12 ) ) -RRB- cord-335975-m6lkrehi 3722 13 and and CC cord-335975-m6lkrehi 3722 14 6 6 CD cord-335975-m6lkrehi 3722 15 patients patient NNS cord-335975-m6lkrehi 3722 16 died die VBD cord-335975-m6lkrehi 3722 17 which which WDT cord-335975-m6lkrehi 3722 18 4 4 CD cord-335975-m6lkrehi 3722 19 within within IN cord-335975-m6lkrehi 3722 20 the the DT cord-335975-m6lkrehi 3722 21 first first JJ cord-335975-m6lkrehi 3722 22 5 5 CD cord-335975-m6lkrehi 3722 23 days day NNS cord-335975-m6lkrehi 3722 24 . . . cord-335975-m6lkrehi 3723 1 Spontaneous spontaneous JJ cord-335975-m6lkrehi 3723 2 Bacterial bacterial JJ cord-335975-m6lkrehi 3723 3 Peritonitis peritonitis NN cord-335975-m6lkrehi 3723 4 ( ( -LRB- cord-335975-m6lkrehi 3723 5 p p NN cord-335975-m6lkrehi 3723 6 0.010 0.010 CD cord-335975-m6lkrehi 3723 7 ) ) -RRB- cord-335975-m6lkrehi 3723 8 , , , cord-335975-m6lkrehi 3723 9 hepatic hepatic JJ cord-335975-m6lkrehi 3723 10 encephalopathy encephalopathy NN cord-335975-m6lkrehi 3723 11 ( ( -LRB- cord-335975-m6lkrehi 3723 12 p p NN cord-335975-m6lkrehi 3723 13 0.041 0.041 CD cord-335975-m6lkrehi 3723 14 ) ) -RRB- cord-335975-m6lkrehi 3723 15 and and CC cord-335975-m6lkrehi 3723 16 the the DT cord-335975-m6lkrehi 3723 17 hemodynamic hemodynamic JJ cord-335975-m6lkrehi 3723 18 instability instability NN cord-335975-m6lkrehi 3723 19 with with IN cord-335975-m6lkrehi 3723 20 schok schok NNP cord-335975-m6lkrehi 3724 1 ( ( -LRB- cord-335975-m6lkrehi 3724 2 p p NN cord-335975-m6lkrehi 3724 3 0.01 0.01 CD cord-335975-m6lkrehi 3724 4 ) ) -RRB- cord-335975-m6lkrehi 3724 5 are be VBP cord-335975-m6lkrehi 3724 6 correlated correlate VBN cord-335975-m6lkrehi 3724 7 with with IN cord-335975-m6lkrehi 3724 8 early early JJ cord-335975-m6lkrehi 3724 9 mortality mortality NN cord-335975-m6lkrehi 3724 10 at at IN cord-335975-m6lkrehi 3724 11 5 5 CD cord-335975-m6lkrehi 3724 12 days day NNS cord-335975-m6lkrehi 3724 13 . . . cord-335975-m6lkrehi 3725 1 Hepatic hepatic JJ cord-335975-m6lkrehi 3725 2 encephalopathy encephalopathy NN cord-335975-m6lkrehi 3725 3 ( ( -LRB- cord-335975-m6lkrehi 3725 4 p p NN cord-335975-m6lkrehi 3725 5 0.028 0.028 CD cord-335975-m6lkrehi 3725 6 ) ) -RRB- cord-335975-m6lkrehi 3725 7 and and CC cord-335975-m6lkrehi 3725 8 bacteremia bacteremia NN cord-335975-m6lkrehi 3725 9 ( ( -LRB- cord-335975-m6lkrehi 3725 10 p p NN cord-335975-m6lkrehi 3725 11 0.05 0.05 CD cord-335975-m6lkrehi 3725 12 ) ) -RRB- cord-335975-m6lkrehi 3725 13 are be VBP cord-335975-m6lkrehi 3725 14 corrolated corrolate VBN cord-335975-m6lkrehi 3725 15 with with IN cord-335975-m6lkrehi 3725 16 6 6 CD cord-335975-m6lkrehi 3725 17 week week NN cord-335975-m6lkrehi 3725 18 motality motality NN cord-335975-m6lkrehi 3725 19 . . . cord-335975-m6lkrehi 3726 1 Non non JJ cord-335975-m6lkrehi 3726 2 selective selective JJ cord-335975-m6lkrehi 3726 3 betablocker betablocker NN cord-335975-m6lkrehi 3726 4 ( ( -LRB- cord-335975-m6lkrehi 3726 5 p p NN cord-335975-m6lkrehi 3726 6 0.013 0.013 CD cord-335975-m6lkrehi 3726 7 ) ) -RRB- cord-335975-m6lkrehi 3726 8 and and CC cord-335975-m6lkrehi 3726 9 primary primary JJ cord-335975-m6lkrehi 3726 10 use use NN cord-335975-m6lkrehi 3726 11 of of IN cord-335975-m6lkrehi 3726 12 band band NN cord-335975-m6lkrehi 3726 13 ligation ligation NN cord-335975-m6lkrehi 3726 14 when when WRB cord-335975-m6lkrehi 3726 15 indicated indicate VBD cord-335975-m6lkrehi 3726 16 ( ( -LRB- cord-335975-m6lkrehi 3726 17 p p NN cord-335975-m6lkrehi 3726 18 0.008 0.008 CD cord-335975-m6lkrehi 3726 19 ) ) -RRB- cord-335975-m6lkrehi 3726 20 are be VBP cord-335975-m6lkrehi 3726 21 protective protective JJ cord-335975-m6lkrehi 3726 22 factors factor NNS cord-335975-m6lkrehi 3726 23 and and CC cord-335975-m6lkrehi 3726 24 parameters parameter NNS cord-335975-m6lkrehi 3726 25 of of IN cord-335975-m6lkrehi 3726 26 good good JJ cord-335975-m6lkrehi 3726 27 outcome outcome NN cord-335975-m6lkrehi 3726 28 . . . cord-335975-m6lkrehi 3727 1 Conclusion conclusion NN cord-335975-m6lkrehi 3727 2 : : : cord-335975-m6lkrehi 3728 1 Despite despite IN cord-335975-m6lkrehi 3728 2 developing develop VBG cord-335975-m6lkrehi 3728 3 of of IN cord-335975-m6lkrehi 3728 4 endoscopic endoscopic JJ cord-335975-m6lkrehi 3728 5 tools tool NNS cord-335975-m6lkrehi 3728 6 and and CC cord-335975-m6lkrehi 3728 7 respect respect NN cord-335975-m6lkrehi 3728 8 of of IN cord-335975-m6lkrehi 3728 9 actual actual JJ cord-335975-m6lkrehi 3728 10 therapeutic therapeutic JJ cord-335975-m6lkrehi 3728 11 guidelines guideline NNS cord-335975-m6lkrehi 3728 12 in in IN cord-335975-m6lkrehi 3728 13 AVH AVH NNP cord-335975-m6lkrehi 3728 14 , , , cord-335975-m6lkrehi 3728 15 the the DT cord-335975-m6lkrehi 3728 16 outcome outcome NN cord-335975-m6lkrehi 3728 17 is be VBZ cord-335975-m6lkrehi 3728 18 still still RB cord-335975-m6lkrehi 3728 19 poor poor JJ cord-335975-m6lkrehi 3728 20 . . . cord-335975-m6lkrehi 3729 1 The the DT cord-335975-m6lkrehi 3729 2 prognosis prognosis NN cord-335975-m6lkrehi 3729 3 appears appear VBZ cord-335975-m6lkrehi 3729 4 to to TO cord-335975-m6lkrehi 3729 5 be be VB cord-335975-m6lkrehi 3729 6 dependent dependent JJ cord-335975-m6lkrehi 3729 7 on on IN cord-335975-m6lkrehi 3729 8 the the DT cord-335975-m6lkrehi 3729 9 clinical clinical JJ cord-335975-m6lkrehi 3729 10 condition condition NN cord-335975-m6lkrehi 3729 11 at at IN cord-335975-m6lkrehi 3729 12 admission admission NN cord-335975-m6lkrehi 3729 13 and and CC cord-335975-m6lkrehi 3729 14 primary primary JJ cord-335975-m6lkrehi 3729 15 prevention prevention NN cord-335975-m6lkrehi 3729 16 . . . cord-335975-m6lkrehi 3730 1 Introduction introduction NN cord-335975-m6lkrehi 3730 2 : : : cord-335975-m6lkrehi 3731 1 The the DT cord-335975-m6lkrehi 3731 2 French french JJ cord-335975-m6lkrehi 3731 3 intestinal intestinal JJ cord-335975-m6lkrehi 3731 4 stroke stroke NN cord-335975-m6lkrehi 3731 5 center center NN cord-335975-m6lkrehi 3731 6 based base VBN cord-335975-m6lkrehi 3731 7 on on IN cord-335975-m6lkrehi 3731 8 a a DT cord-335975-m6lkrehi 3731 9 multimodal multimodal NN cord-335975-m6lkrehi 3731 10 and and CC cord-335975-m6lkrehi 3731 11 multidisciplinary multidisciplinary JJ cord-335975-m6lkrehi 3731 12 management management NN cord-335975-m6lkrehi 3731 13 has have VBZ cord-335975-m6lkrehi 3731 14 been be VBN cord-335975-m6lkrehi 3731 15 developed develop VBN cord-335975-m6lkrehi 3731 16 to to TO cord-335975-m6lkrehi 3731 17 improve improve VB cord-335975-m6lkrehi 3731 18 survival survival NN cord-335975-m6lkrehi 3731 19 and and CC cord-335975-m6lkrehi 3731 20 intestinal intestinal JJ cord-335975-m6lkrehi 3731 21 viability viability NN cord-335975-m6lkrehi 3731 22 . . . cord-335975-m6lkrehi 3732 1 Open open VB cord-335975-m6lkrehi 3732 2 surgical surgical JJ cord-335975-m6lkrehi 3732 3 revascularization revascularization NN cord-335975-m6lkrehi 3732 4 was be VBD cord-335975-m6lkrehi 3732 5 decided decide VBN cord-335975-m6lkrehi 3732 6 for for IN cord-335975-m6lkrehi 3732 7 patients patient NNS cord-335975-m6lkrehi 3732 8 unsuitable unsuitable JJ cord-335975-m6lkrehi 3732 9 for for IN cord-335975-m6lkrehi 3732 10 radiological radiological JJ cord-335975-m6lkrehi 3732 11 revascularization revascularization NN cord-335975-m6lkrehi 3732 12 and and CC cord-335975-m6lkrehi 3732 13 or or CC cord-335975-m6lkrehi 3732 14 suspected suspect VBN cord-335975-m6lkrehi 3732 15 of of IN cord-335975-m6lkrehi 3732 16 intestinal intestinal JJ cord-335975-m6lkrehi 3732 17 necrosis necrosis NN cord-335975-m6lkrehi 3732 18 . . . cord-335975-m6lkrehi 3733 1 We -PRON- PRP cord-335975-m6lkrehi 3733 2 aimed aim VBD cord-335975-m6lkrehi 3733 3 to to TO cord-335975-m6lkrehi 3733 4 study study VB cord-335975-m6lkrehi 3733 5 the the DT cord-335975-m6lkrehi 3733 6 prognosis prognosis NN cord-335975-m6lkrehi 3733 7 of of IN cord-335975-m6lkrehi 3733 8 patients patient NNS cord-335975-m6lkrehi 3733 9 suffering suffer VBG cord-335975-m6lkrehi 3733 10 from from IN cord-335975-m6lkrehi 3733 11 AOAMI AOAMI NNP cord-335975-m6lkrehi 3733 12 in in IN cord-335975-m6lkrehi 3733 13 ICU ICU NNP cord-335975-m6lkrehi 3733 14 and and CC cord-335975-m6lkrehi 3733 15 who who WP cord-335975-m6lkrehi 3733 16 have have VBP cord-335975-m6lkrehi 3733 17 benefited benefit VBN cord-335975-m6lkrehi 3733 18 from from IN cord-335975-m6lkrehi 3733 19 open open JJ cord-335975-m6lkrehi 3733 20 revascularization revascularization NN cord-335975-m6lkrehi 3733 21 . . . cord-335975-m6lkrehi 3734 1 Single single JJ cord-335975-m6lkrehi 3734 2 - - HYPH cord-335975-m6lkrehi 3734 3 center center NN cord-335975-m6lkrehi 3734 4 , , , cord-335975-m6lkrehi 3734 5 observational observational JJ cord-335975-m6lkrehi 3734 6 and and CC cord-335975-m6lkrehi 3734 7 prospective prospective JJ cord-335975-m6lkrehi 3734 8 study study NN cord-335975-m6lkrehi 3734 9 was be VBD cord-335975-m6lkrehi 3734 10 carried carry VBN cord-335975-m6lkrehi 3734 11 out out RP cord-335975-m6lkrehi 3734 12 in in IN cord-335975-m6lkrehi 3734 13 a a DT cord-335975-m6lkrehi 3734 14 surgical surgical JJ cord-335975-m6lkrehi 3734 15 ICU icu NN cord-335975-m6lkrehi 3734 16 of of IN cord-335975-m6lkrehi 3734 17 a a DT cord-335975-m6lkrehi 3734 18 tertiary tertiary JJ cord-335975-m6lkrehi 3734 19 center center NN cord-335975-m6lkrehi 3734 20 . . . cord-335975-m6lkrehi 3735 1 Patients patient NNS cord-335975-m6lkrehi 3735 2 with with IN cord-335975-m6lkrehi 3735 3 AOAMI AOAMI NNP cord-335975-m6lkrehi 3735 4 managed manage VBD cord-335975-m6lkrehi 3735 5 in in IN cord-335975-m6lkrehi 3735 6 our -PRON- PRP$ cord-335975-m6lkrehi 3735 7 intestinal intestinal JJ cord-335975-m6lkrehi 3735 8 stroke stroke NN cord-335975-m6lkrehi 3735 9 center center NN cord-335975-m6lkrehi 3735 10 from from IN cord-335975-m6lkrehi 3735 11 01 01 CD cord-335975-m6lkrehi 3735 12 2016 2016 CD cord-335975-m6lkrehi 3735 13 to to IN cord-335975-m6lkrehi 3735 14 09 09 CD cord-335975-m6lkrehi 3735 15 2017 2017 CD cord-335975-m6lkrehi 3735 16 and and CC cord-335975-m6lkrehi 3735 17 who who WP cord-335975-m6lkrehi 3735 18 underwent undergo VBD cord-335975-m6lkrehi 3735 19 open open JJ cord-335975-m6lkrehi 3735 20 revascularization revascularization NN cord-335975-m6lkrehi 3735 21 were be VBD cord-335975-m6lkrehi 3735 22 included include VBN cord-335975-m6lkrehi 3735 23 . . . cord-335975-m6lkrehi 3736 1 Results result NNS cord-335975-m6lkrehi 3736 2 : : : cord-335975-m6lkrehi 3737 1 Data datum NNS cord-335975-m6lkrehi 3737 2 of of IN cord-335975-m6lkrehi 3737 3 15 15 CD cord-335975-m6lkrehi 3737 4 patients patient NNS cord-335975-m6lkrehi 3737 5 were be VBD cord-335975-m6lkrehi 3737 6 collected collect VBN cord-335975-m6lkrehi 3737 7 . . . cord-335975-m6lkrehi 3738 1 Patients patient NNS cord-335975-m6lkrehi 3738 2 ' ' POS cord-335975-m6lkrehi 3738 3 characteristics characteristic NNS cord-335975-m6lkrehi 3738 4 are be VBP cord-335975-m6lkrehi 3738 5 described describe VBN cord-335975-m6lkrehi 3738 6 in in IN cord-335975-m6lkrehi 3738 7 Table Table NNP cord-335975-m6lkrehi 3738 8 1 1 CD cord-335975-m6lkrehi 3738 9 . . . cord-335975-m6lkrehi 3739 1 All all DT cord-335975-m6lkrehi 3739 2 patients patient NNS cord-335975-m6lkrehi 3739 3 had have VBD cord-335975-m6lkrehi 3739 4 abdominal abdominal JJ cord-335975-m6lkrehi 3739 5 computed compute VBN cord-335975-m6lkrehi 3739 6 tomography tomography NN cord-335975-m6lkrehi 3739 7 angiography angiography NN cord-335975-m6lkrehi 3739 8 at at IN cord-335975-m6lkrehi 3739 9 the the DT cord-335975-m6lkrehi 3739 10 diagnosis diagnosis NN cord-335975-m6lkrehi 3739 11 , , , cord-335975-m6lkrehi 3739 12 and and CC cord-335975-m6lkrehi 3739 13 11 11 CD cord-335975-m6lkrehi 3739 14 patients patient NNS cord-335975-m6lkrehi 3739 15 ( ( -LRB- cord-335975-m6lkrehi 3739 16 73 73 CD cord-335975-m6lkrehi 3739 17 % % NN cord-335975-m6lkrehi 3739 18 ) ) -RRB- cord-335975-m6lkrehi 3739 19 presented present VBD cord-335975-m6lkrehi 3739 20 signs sign NNS cord-335975-m6lkrehi 3739 21 of of IN cord-335975-m6lkrehi 3739 22 intestinal intestinal JJ cord-335975-m6lkrehi 3739 23 injury injury NN cord-335975-m6lkrehi 3739 24 . . . cord-335975-m6lkrehi 3740 1 Thrombosis thrombosis NN cord-335975-m6lkrehi 3740 2 was be VBD cord-335975-m6lkrehi 3740 3 the the DT cord-335975-m6lkrehi 3740 4 main main JJ cord-335975-m6lkrehi 3740 5 mechanism mechanism NN cord-335975-m6lkrehi 3740 6 of of IN cord-335975-m6lkrehi 3740 7 superior superior JJ cord-335975-m6lkrehi 3740 8 mesenteric mesenteric JJ cord-335975-m6lkrehi 3740 9 artery artery NN cord-335975-m6lkrehi 3740 10 ( ( -LRB- cord-335975-m6lkrehi 3740 11 SMA SMA NNP cord-335975-m6lkrehi 3740 12 ) ) -RRB- cord-335975-m6lkrehi 3740 13 occlusion occlusion NN cord-335975-m6lkrehi 3740 14 ( ( -LRB- cord-335975-m6lkrehi 3740 15 14 14 CD cord-335975-m6lkrehi 3740 16 patients patient NNS cord-335975-m6lkrehi 3740 17 , , , cord-335975-m6lkrehi 3740 18 93 93 CD cord-335975-m6lkrehi 3740 19 % % NN cord-335975-m6lkrehi 3740 20 ) ) -RRB- cord-335975-m6lkrehi 3740 21 . . . cord-335975-m6lkrehi 3741 1 All all DT cord-335975-m6lkrehi 3741 2 patients patient NNS cord-335975-m6lkrehi 3741 3 received receive VBD cord-335975-m6lkrehi 3741 4 antiplatelet antiplatelet JJ cord-335975-m6lkrehi 3741 5 therapy therapy NN cord-335975-m6lkrehi 3741 6 , , , cord-335975-m6lkrehi 3741 7 curative curative JJ cord-335975-m6lkrehi 3741 8 unfractionated unfractionated JJ cord-335975-m6lkrehi 3741 9 heparin heparin NN cord-335975-m6lkrehi 3741 10 therapy therapy NN cord-335975-m6lkrehi 3741 11 and and CC cord-335975-m6lkrehi 3741 12 digestive digestive JJ cord-335975-m6lkrehi 3741 13 decontamination decontamination NN cord-335975-m6lkrehi 3741 14 . . . cord-335975-m6lkrehi 3742 1 Open open JJ cord-335975-m6lkrehi 3742 2 revascularization revascularization NN cord-335975-m6lkrehi 3742 3 was be VBD cord-335975-m6lkrehi 3742 4 performed perform VBN cord-335975-m6lkrehi 3742 5 by by IN cord-335975-m6lkrehi 3742 6 SMA SMA NNP cord-335975-m6lkrehi 3742 7 endarterectomy endarterectomy NN cord-335975-m6lkrehi 3742 8 ( ( -LRB- cord-335975-m6lkrehi 3742 9 4 4 CD cord-335975-m6lkrehi 3742 10 patients patient NNS cord-335975-m6lkrehi 3742 11 , , , cord-335975-m6lkrehi 3742 12 27 27 CD cord-335975-m6lkrehi 3742 13 % % NN cord-335975-m6lkrehi 3742 14 ) ) -RRB- cord-335975-m6lkrehi 3742 15 , , , cord-335975-m6lkrehi 3742 16 SMA SMA NNP cord-335975-m6lkrehi 3742 17 surgical surgical JJ cord-335975-m6lkrehi 3742 18 bypass bypass NN cord-335975-m6lkrehi 3742 19 ( ( -LRB- cord-335975-m6lkrehi 3742 20 8 8 CD cord-335975-m6lkrehi 3742 21 patients patient NNS cord-335975-m6lkrehi 3742 22 , , , cord-335975-m6lkrehi 3742 23 53 53 CD cord-335975-m6lkrehi 3742 24 % % NN cord-335975-m6lkrehi 3742 25 ) ) -RRB- cord-335975-m6lkrehi 3742 26 , , , cord-335975-m6lkrehi 3742 27 retrograde retrograde JJ cord-335975-m6lkrehi 3742 28 open open JJ cord-335975-m6lkrehi 3742 29 mesenteric mesenteric JJ cord-335975-m6lkrehi 3742 30 stenting stenting NN cord-335975-m6lkrehi 3742 31 ( ( -LRB- cord-335975-m6lkrehi 3742 32 3 3 CD cord-335975-m6lkrehi 3742 33 patients patient NNS cord-335975-m6lkrehi 3742 34 , , , cord-335975-m6lkrehi 3742 35 20 20 CD cord-335975-m6lkrehi 3742 36 % % NN cord-335975-m6lkrehi 3742 37 ) ) -RRB- cord-335975-m6lkrehi 3742 38 and and CC cord-335975-m6lkrehi 3742 39 coeliac coeliac JJ cord-335975-m6lkrehi 3742 40 artery artery NN cord-335975-m6lkrehi 3742 41 bypass bypass NN cord-335975-m6lkrehi 3742 42 ( ( -LRB- cord-335975-m6lkrehi 3742 43 2 2 CD cord-335975-m6lkrehi 3742 44 patients patient NNS cord-335975-m6lkrehi 3742 45 , , , cord-335975-m6lkrehi 3742 46 13 13 CD cord-335975-m6lkrehi 3742 47 % % NN cord-335975-m6lkrehi 3742 48 ) ) -RRB- cord-335975-m6lkrehi 3742 49 . . . cord-335975-m6lkrehi 3743 1 Three three CD cord-335975-m6lkrehi 3743 2 patients patient NNS cord-335975-m6lkrehi 3743 3 ( ( -LRB- cord-335975-m6lkrehi 3743 4 20 20 CD cord-335975-m6lkrehi 3743 5 % % NN cord-335975-m6lkrehi 3743 6 ) ) -RRB- cord-335975-m6lkrehi 3743 7 underwent undergo VBD cord-335975-m6lkrehi 3743 8 a a DT cord-335975-m6lkrehi 3743 9 radiologic radiologic JJ cord-335975-m6lkrehi 3743 10 endovascular endovascular JJ cord-335975-m6lkrehi 3743 11 revascularization revascularization NN cord-335975-m6lkrehi 3743 12 attempt attempt NN cord-335975-m6lkrehi 3743 13 before before IN cord-335975-m6lkrehi 3743 14 open open JJ cord-335975-m6lkrehi 3743 15 repair repair NN cord-335975-m6lkrehi 3743 16 . . . cord-335975-m6lkrehi 3744 1 Small small JJ cord-335975-m6lkrehi 3744 2 bowel bowel NN cord-335975-m6lkrehi 3744 3 resection resection NN cord-335975-m6lkrehi 3744 4 ( ( -LRB- cord-335975-m6lkrehi 3744 5 100 100 CD cord-335975-m6lkrehi 3744 6 cm cm NNS cord-335975-m6lkrehi 3744 7 ) ) -RRB- cord-335975-m6lkrehi 3744 8 was be VBD cord-335975-m6lkrehi 3744 9 achieved achieve VBN cord-335975-m6lkrehi 3744 10 in in IN cord-335975-m6lkrehi 3744 11 8 8 CD cord-335975-m6lkrehi 3744 12 patients patient NNS cord-335975-m6lkrehi 3744 13 ( ( -LRB- cord-335975-m6lkrehi 3744 14 53 53 CD cord-335975-m6lkrehi 3744 15 % % NN cord-335975-m6lkrehi 3744 16 ) ) -RRB- cord-335975-m6lkrehi 3744 17 . . . cord-335975-m6lkrehi 3745 1 Four four CD cord-335975-m6lkrehi 3745 2 patients patient NNS cord-335975-m6lkrehi 3745 3 ( ( -LRB- cord-335975-m6lkrehi 3745 4 27 27 CD cord-335975-m6lkrehi 3745 5 % % NN cord-335975-m6lkrehi 3745 6 ) ) -RRB- cord-335975-m6lkrehi 3745 7 had have VBD cord-335975-m6lkrehi 3745 8 peritonitis peritonitis NN cord-335975-m6lkrehi 3745 9 . . . cord-335975-m6lkrehi 3746 1 Six six CD cord-335975-m6lkrehi 3746 2 patients patient NNS cord-335975-m6lkrehi 3746 3 ( ( -LRB- cord-335975-m6lkrehi 3746 4 40 40 CD cord-335975-m6lkrehi 3746 5 % % NN cord-335975-m6lkrehi 3746 6 ) ) -RRB- cord-335975-m6lkrehi 3746 7 had have VBD cord-335975-m6lkrehi 3746 8 one one CD cord-335975-m6lkrehi 3746 9 or or CC cord-335975-m6lkrehi 3746 10 more more JJR cord-335975-m6lkrehi 3746 11 relaparotomy relaparotomy NN cord-335975-m6lkrehi 3746 12 ] ] -RRB- cord-335975-m6lkrehi 3746 13 ) ) -RRB- cord-335975-m6lkrehi 3746 14 , , , cord-335975-m6lkrehi 3746 15 usually usually RB cord-335975-m6lkrehi 3746 16 for for IN cord-335975-m6lkrehi 3746 17 hemodynamic hemodynamic JJ cord-335975-m6lkrehi 3746 18 instability instability NN cord-335975-m6lkrehi 3746 19 ( ( -LRB- cord-335975-m6lkrehi 3746 20 83 83 CD cord-335975-m6lkrehi 3746 21 % % NN cord-335975-m6lkrehi 3746 22 ) ) -RRB- cord-335975-m6lkrehi 3746 23 . . . cord-335975-m6lkrehi 3747 1 Only only RB cord-335975-m6lkrehi 3747 2 one one CD cord-335975-m6lkrehi 3747 3 patient patient NN cord-335975-m6lkrehi 3747 4 died die VBD cord-335975-m6lkrehi 3747 5 in in IN cord-335975-m6lkrehi 3747 6 ICU ICU NNP cord-335975-m6lkrehi 3747 7 ( ( -LRB- cord-335975-m6lkrehi 3747 8 7 7 CD cord-335975-m6lkrehi 3747 9 % % NN cord-335975-m6lkrehi 3747 10 ) ) -RRB- cord-335975-m6lkrehi 3747 11 . . . cord-335975-m6lkrehi 3748 1 ICU ICU NNP cord-335975-m6lkrehi 3748 2 lenght lenght NN cord-335975-m6lkrehi 3748 3 of of IN cord-335975-m6lkrehi 3748 4 stay stay NN cord-335975-m6lkrehi 3748 5 was be VBD cord-335975-m6lkrehi 3748 6 7 7 CD cord-335975-m6lkrehi 3748 7 days day NNS cord-335975-m6lkrehi 3748 8 ] ] -RRB- cord-335975-m6lkrehi 3748 9 and and CC cord-335975-m6lkrehi 3748 10 duration duration NN cord-335975-m6lkrehi 3748 11 of of IN cord-335975-m6lkrehi 3748 12 mechanical mechanical JJ cord-335975-m6lkrehi 3748 13 ventilation ventilation NN cord-335975-m6lkrehi 3748 14 was be VBD cord-335975-m6lkrehi 3748 15 3 3 CD cord-335975-m6lkrehi 3748 16 days day NNS cord-335975-m6lkrehi 3749 1 [ [ -LRB- cord-335975-m6lkrehi 3749 2 IQR IQR NNP cord-335975-m6lkrehi 3749 3 0 0 CD cord-335975-m6lkrehi 3749 4 - - SYM cord-335975-m6lkrehi 3749 5 7 7 CD cord-335975-m6lkrehi 3749 6 ] ] -RRB- cord-335975-m6lkrehi 3749 7 . . . cord-335975-m6lkrehi 3750 1 Overall overall RB cord-335975-m6lkrehi 3750 2 , , , cord-335975-m6lkrehi 3750 3 haemodynamic haemodynamic JJ cord-335975-m6lkrehi 3750 4 failure failure NN cord-335975-m6lkrehi 3750 5 was be VBD cord-335975-m6lkrehi 3750 6 present present JJ cord-335975-m6lkrehi 3750 7 in in IN cord-335975-m6lkrehi 3750 8 10 10 CD cord-335975-m6lkrehi 3750 9 patients patient NNS cord-335975-m6lkrehi 3750 10 ( ( -LRB- cord-335975-m6lkrehi 3750 11 67 67 CD cord-335975-m6lkrehi 3750 12 % % NN cord-335975-m6lkrehi 3750 13 ) ) -RRB- cord-335975-m6lkrehi 3750 14 . . . cord-335975-m6lkrehi 3751 1 Median median JJ cord-335975-m6lkrehi 3751 2 duration duration NN cord-335975-m6lkrehi 3751 3 of of IN cord-335975-m6lkrehi 3751 4 vasoactive vasoactive JJ cord-335975-m6lkrehi 3751 5 support support NN cord-335975-m6lkrehi 3751 6 was be VBD cord-335975-m6lkrehi 3751 7 2 2 CD cord-335975-m6lkrehi 3751 8 days day NNS cord-335975-m6lkrehi 3751 9 [ [ -LRB- cord-335975-m6lkrehi 3751 10 IQR IQR NNP cord-335975-m6lkrehi 3751 11 0 0 CD cord-335975-m6lkrehi 3751 12 - - SYM cord-335975-m6lkrehi 3751 13 4 4 CD cord-335975-m6lkrehi 3751 14 ] ] -RRB- cord-335975-m6lkrehi 3751 15 ) ) -RRB- cord-335975-m6lkrehi 3751 16 . . . cord-335975-m6lkrehi 3752 1 Severe severe JJ cord-335975-m6lkrehi 3752 2 acute acute JJ cord-335975-m6lkrehi 3752 3 respiratory respiratory JJ cord-335975-m6lkrehi 3752 4 distress distress NN cord-335975-m6lkrehi 3752 5 syndrome syndrome NN cord-335975-m6lkrehi 3752 6 was be VBD cord-335975-m6lkrehi 3752 7 observed observe VBN cord-335975-m6lkrehi 3752 8 in in IN cord-335975-m6lkrehi 3752 9 2 2 CD cord-335975-m6lkrehi 3752 10 patients patient NNS cord-335975-m6lkrehi 3752 11 ( ( -LRB- cord-335975-m6lkrehi 3752 12 13 13 CD cord-335975-m6lkrehi 3752 13 % % NN cord-335975-m6lkrehi 3752 14 ) ) -RRB- cord-335975-m6lkrehi 3752 15 and and CC cord-335975-m6lkrehi 3752 16 acute acute JJ cord-335975-m6lkrehi 3752 17 kidney kidney NN cord-335975-m6lkrehi 3752 18 injury injury NN cord-335975-m6lkrehi 3752 19 in in IN cord-335975-m6lkrehi 3752 20 9 9 CD cord-335975-m6lkrehi 3752 21 patients patient NNS cord-335975-m6lkrehi 3752 22 ( ( -LRB- cord-335975-m6lkrehi 3752 23 60 60 CD cord-335975-m6lkrehi 3752 24 % % NN cord-335975-m6lkrehi 3752 25 , , , cord-335975-m6lkrehi 3752 26 including include VBG cord-335975-m6lkrehi 3752 27 2 2 CD cord-335975-m6lkrehi 3752 28 patients patient NNS cord-335975-m6lkrehi 3752 29 who who WP cord-335975-m6lkrehi 3752 30 received receive VBD cord-335975-m6lkrehi 3752 31 renal renal JJ cord-335975-m6lkrehi 3752 32 - - HYPH cord-335975-m6lkrehi 3752 33 replacement replacement NN cord-335975-m6lkrehi 3752 34 therapy therapy NN cord-335975-m6lkrehi 3752 35 , , , cord-335975-m6lkrehi 3752 36 13 13 CD cord-335975-m6lkrehi 3752 37 % % NN cord-335975-m6lkrehi 3752 38 ) ) -RRB- cord-335975-m6lkrehi 3752 39 . . . cord-335975-m6lkrehi 3753 1 Enteral enteral NN cord-335975-m6lkrehi 3753 2 feeding feeding NN cord-335975-m6lkrehi 3753 3 was be VBD cord-335975-m6lkrehi 3753 4 initiated initiate VBN cord-335975-m6lkrehi 3753 5 in in IN cord-335975-m6lkrehi 3753 6 6 6 CD cord-335975-m6lkrehi 3753 7 patients patient NNS cord-335975-m6lkrehi 3753 8 ( ( -LRB- cord-335975-m6lkrehi 3753 9 40 40 CD cord-335975-m6lkrehi 3753 10 % % NN cord-335975-m6lkrehi 3753 11 ) ) -RRB- cord-335975-m6lkrehi 3753 12 with with IN cord-335975-m6lkrehi 3753 13 a a DT cord-335975-m6lkrehi 3753 14 delay delay NN cord-335975-m6lkrehi 3753 15 of of IN cord-335975-m6lkrehi 3753 16 3.5 3.5 CD cord-335975-m6lkrehi 3753 17 days day NNS cord-335975-m6lkrehi 3753 18 [ [ -LRB- cord-335975-m6lkrehi 3753 19 . . . cord-335975-m6lkrehi 3754 1 Parenteral parenteral JJ cord-335975-m6lkrehi 3754 2 nutrition nutrition NN cord-335975-m6lkrehi 3754 3 was be VBD cord-335975-m6lkrehi 3754 4 administered administer VBN cord-335975-m6lkrehi 3754 5 in in IN cord-335975-m6lkrehi 3754 6 13 13 CD cord-335975-m6lkrehi 3754 7 patients patient NNS cord-335975-m6lkrehi 3754 8 ( ( -LRB- cord-335975-m6lkrehi 3754 9 87 87 CD cord-335975-m6lkrehi 3754 10 % % NN cord-335975-m6lkrehi 3754 11 ) ) -RRB- cord-335975-m6lkrehi 3754 12 , , , cord-335975-m6lkrehi 3754 13 including include VBG cord-335975-m6lkrehi 3754 14 8 8 CD cord-335975-m6lkrehi 3754 15 patients patient NNS cord-335975-m6lkrehi 3754 16 ( ( -LRB- cord-335975-m6lkrehi 3754 17 53 53 CD cord-335975-m6lkrehi 3754 18 % % NN cord-335975-m6lkrehi 3754 19 ) ) -RRB- cord-335975-m6lkrehi 3754 20 without without IN cord-335975-m6lkrehi 3754 21 enteral enteral NN cord-335975-m6lkrehi 3754 22 feeding feed VBG cord-335975-m6lkrehi 3754 23 . . . cord-335975-m6lkrehi 3755 1 Five five CD cord-335975-m6lkrehi 3755 2 patients patient NNS cord-335975-m6lkrehi 3755 3 ( ( -LRB- cord-335975-m6lkrehi 3755 4 33 33 CD cord-335975-m6lkrehi 3755 5 % % NN cord-335975-m6lkrehi 3755 6 ) ) -RRB- cord-335975-m6lkrehi 3755 7 were be VBD cord-335975-m6lkrehi 3755 8 discharged discharge VBN cord-335975-m6lkrehi 3755 9 with with IN cord-335975-m6lkrehi 3755 10 small small JJ cord-335975-m6lkrehi 3755 11 bowel bowel NN cord-335975-m6lkrehi 3755 12 syndrome syndrome NN cord-335975-m6lkrehi 3755 13 . . . cord-335975-m6lkrehi 3756 1 Conclusion conclusion NN cord-335975-m6lkrehi 3756 2 : : : cord-335975-m6lkrehi 3756 3 ICU ICU NNP cord-335975-m6lkrehi 3756 4 patients patient NNS cord-335975-m6lkrehi 3756 5 who who WP cord-335975-m6lkrehi 3756 6 underwent undergo VBD cord-335975-m6lkrehi 3756 7 open open JJ cord-335975-m6lkrehi 3756 8 revascularization revascularization NN cord-335975-m6lkrehi 3756 9 to to TO cord-335975-m6lkrehi 3756 10 treat treat VB cord-335975-m6lkrehi 3756 11 AOAMI AOAMI NNP cord-335975-m6lkrehi 3756 12 as as IN cord-335975-m6lkrehi 3756 13 part part NN cord-335975-m6lkrehi 3756 14 of of IN cord-335975-m6lkrehi 3756 15 a a DT cord-335975-m6lkrehi 3756 16 multimodal multimodal NN cord-335975-m6lkrehi 3756 17 and and CC cord-335975-m6lkrehi 3756 18 multidisciplinary multidisciplinary JJ cord-335975-m6lkrehi 3756 19 management management NN cord-335975-m6lkrehi 3756 20 in in IN cord-335975-m6lkrehi 3756 21 a a DT cord-335975-m6lkrehi 3756 22 dedicated dedicated JJ cord-335975-m6lkrehi 3756 23 intestinal intestinal JJ cord-335975-m6lkrehi 3756 24 stroke stroke NN cord-335975-m6lkrehi 3756 25 center center NN cord-335975-m6lkrehi 3756 26 have have VBP cord-335975-m6lkrehi 3756 27 low low JJ cord-335975-m6lkrehi 3756 28 mortality mortality NN cord-335975-m6lkrehi 3756 29 and and CC cord-335975-m6lkrehi 3756 30 intestinal intestinal JJ cord-335975-m6lkrehi 3756 31 resection resection NN cord-335975-m6lkrehi 3756 32 rates rate NNS cord-335975-m6lkrehi 3756 33 . . . cord-335975-m6lkrehi 3757 1 Larger large JJR cord-335975-m6lkrehi 3757 2 studies study NNS cord-335975-m6lkrehi 3757 3 are be VBP cord-335975-m6lkrehi 3757 4 needed need VBN cord-335975-m6lkrehi 3757 5 to to TO cord-335975-m6lkrehi 3757 6 confirm confirm VB cord-335975-m6lkrehi 3757 7 these these DT cord-335975-m6lkrehi 3757 8 results result NNS cord-335975-m6lkrehi 3757 9 . . . cord-335975-m6lkrehi 3758 1 Introduction introduction NN cord-335975-m6lkrehi 3758 2 : : : cord-335975-m6lkrehi 3759 1 Precise precise JJ cord-335975-m6lkrehi 3759 2 consequences consequence NNS cord-335975-m6lkrehi 3759 3 of of IN cord-335975-m6lkrehi 3759 4 late late JJ cord-335975-m6lkrehi 3759 5 transit transit NN cord-335975-m6lkrehi 3759 6 in in IN cord-335975-m6lkrehi 3759 7 ICU ICU NNP cord-335975-m6lkrehi 3759 8 remain remain VBP cord-335975-m6lkrehi 3759 9 elusive elusive JJ cord-335975-m6lkrehi 3759 10 . . . cord-335975-m6lkrehi 3760 1 We -PRON- PRP cord-335975-m6lkrehi 3760 2 have have VBP cord-335975-m6lkrehi 3760 3 previously previously RB cord-335975-m6lkrehi 3760 4 shown show VBN cord-335975-m6lkrehi 3760 5 that that IN cord-335975-m6lkrehi 3760 6 defining define VBG cord-335975-m6lkrehi 3760 7 late late JJ cord-335975-m6lkrehi 3760 8 transit transit NN cord-335975-m6lkrehi 3760 9 by by IN cord-335975-m6lkrehi 3760 10 the the DT cord-335975-m6lkrehi 3760 11 absence absence NN cord-335975-m6lkrehi 3760 12 of of IN cord-335975-m6lkrehi 3760 13 stool stool NN cord-335975-m6lkrehi 3760 14 within within IN cord-335975-m6lkrehi 3760 15 6 6 CD cord-335975-m6lkrehi 3760 16 days day NNS cord-335975-m6lkrehi 3760 17 after after IN cord-335975-m6lkrehi 3760 18 admission admission NN cord-335975-m6lkrehi 3760 19 was be VBD cord-335975-m6lkrehi 3760 20 not not RB cord-335975-m6lkrehi 3760 21 relevant relevant JJ cord-335975-m6lkrehi 3760 22 because because IN cord-335975-m6lkrehi 3760 23 it -PRON- PRP cord-335975-m6lkrehi 3760 24 did do VBD cord-335975-m6lkrehi 3760 25 not not RB cord-335975-m6lkrehi 3760 26 identify identify VB cord-335975-m6lkrehi 3760 27 a a DT cord-335975-m6lkrehi 3760 28 group group NN cord-335975-m6lkrehi 3760 29 of of IN cord-335975-m6lkrehi 3760 30 patients patient NNS cord-335975-m6lkrehi 3760 31 with with IN cord-335975-m6lkrehi 3760 32 specific specific JJ cord-335975-m6lkrehi 3760 33 outcome outcome NN cord-335975-m6lkrehi 3760 34 [ [ -LRB- cord-335975-m6lkrehi 3760 35 1 1 CD cord-335975-m6lkrehi 3760 36 ] ] -RRB- cord-335975-m6lkrehi 3760 37 . . . cord-335975-m6lkrehi 3761 1 To to TO cord-335975-m6lkrehi 3761 2 further further RB cord-335975-m6lkrehi 3761 3 improve improve VB cord-335975-m6lkrehi 3761 4 this this DT cord-335975-m6lkrehi 3761 5 definition definition NN cord-335975-m6lkrehi 3761 6 , , , cord-335975-m6lkrehi 3761 7 we -PRON- PRP cord-335975-m6lkrehi 3761 8 investigated investigate VBD cord-335975-m6lkrehi 3761 9 the the DT cord-335975-m6lkrehi 3761 10 differences difference NNS cord-335975-m6lkrehi 3761 11 in in IN cord-335975-m6lkrehi 3761 12 outcome outcome NN cord-335975-m6lkrehi 3761 13 among among IN cord-335975-m6lkrehi 3761 14 patients patient NNS cord-335975-m6lkrehi 3761 15 according accord VBG cord-335975-m6lkrehi 3761 16 to to IN cord-335975-m6lkrehi 3761 17 their -PRON- PRP$ cord-335975-m6lkrehi 3761 18 bowel bowel NN cord-335975-m6lkrehi 3761 19 movements movement NNS cord-335975-m6lkrehi 3761 20 frequency frequency NN cord-335975-m6lkrehi 3761 21 . . . cord-335975-m6lkrehi 3762 1 Patients patient NNS cord-335975-m6lkrehi 3762 2 and and CC cord-335975-m6lkrehi 3762 3 methods method NNS cord-335975-m6lkrehi 3762 4 : : : cord-335975-m6lkrehi 3762 5 Preliminary preliminary JJ cord-335975-m6lkrehi 3762 6 results result NNS cord-335975-m6lkrehi 3762 7 of of IN cord-335975-m6lkrehi 3762 8 a a DT cord-335975-m6lkrehi 3762 9 prospective prospective NN cord-335975-m6lkrehi 3762 10 , , , cord-335975-m6lkrehi 3762 11 two two CD cord-335975-m6lkrehi 3762 12 centers center NNS cord-335975-m6lkrehi 3762 13 , , , cord-335975-m6lkrehi 3762 14 observational observational JJ cord-335975-m6lkrehi 3762 15 study study NN cord-335975-m6lkrehi 3762 16 . . . cord-335975-m6lkrehi 3763 1 All all DT cord-335975-m6lkrehi 3763 2 patients patient NNS cord-335975-m6lkrehi 3763 3 admitted admit VBD cord-335975-m6lkrehi 3763 4 to to IN cord-335975-m6lkrehi 3763 5 ICU ICU NNP cord-335975-m6lkrehi 3763 6 , , , cord-335975-m6lkrehi 3763 7 with with IN cord-335975-m6lkrehi 3763 8 a a DT cord-335975-m6lkrehi 3763 9 length length NN cord-335975-m6lkrehi 3763 10 of of IN cord-335975-m6lkrehi 3763 11 stay stay NN cord-335975-m6lkrehi 3763 12 ( ( -LRB- cord-335975-m6lkrehi 3763 13 LOS LOS NNP cord-335975-m6lkrehi 3763 14 ) ) -RRB- cord-335975-m6lkrehi 3763 15 of of IN cord-335975-m6lkrehi 3763 16 at at RB cord-335975-m6lkrehi 3763 17 least least JJS cord-335975-m6lkrehi 3763 18 72 72 CD cord-335975-m6lkrehi 3763 19 h h NN cord-335975-m6lkrehi 3763 20 were be VBD cord-335975-m6lkrehi 3763 21 eligible eligible JJ cord-335975-m6lkrehi 3763 22 and and CC cord-335975-m6lkrehi 3763 23 included include VBN cord-335975-m6lkrehi 3763 24 with with IN cord-335975-m6lkrehi 3763 25 the the DT cord-335975-m6lkrehi 3763 26 following follow VBG cord-335975-m6lkrehi 3763 27 exceptions exception NNS cord-335975-m6lkrehi 3763 28 - - : cord-335975-m6lkrehi 3763 29 abdominal abdominal JJ cord-335975-m6lkrehi 3763 30 surgery surgery NN cord-335975-m6lkrehi 3763 31 , , , cord-335975-m6lkrehi 3763 32 bowel bowel NN cord-335975-m6lkrehi 3763 33 infection infection NN cord-335975-m6lkrehi 3763 34 or or CC cord-335975-m6lkrehi 3763 35 any any DT cord-335975-m6lkrehi 3763 36 baseline baseline JJ cord-335975-m6lkrehi 3763 37 condition condition NN cord-335975-m6lkrehi 3763 38 known know VBN cord-335975-m6lkrehi 3763 39 to to TO cord-335975-m6lkrehi 3763 40 alter alter VB cord-335975-m6lkrehi 3763 41 transit transit NN cord-335975-m6lkrehi 3763 42 time time NN cord-335975-m6lkrehi 3763 43 . . . cord-335975-m6lkrehi 3764 1 Patients patient NNS cord-335975-m6lkrehi 3764 2 were be VBD cord-335975-m6lkrehi 3764 3 compared compare VBN cord-335975-m6lkrehi 3764 4 according accord VBG cord-335975-m6lkrehi 3764 5 to to IN cord-335975-m6lkrehi 3764 6 stool stool NN cord-335975-m6lkrehi 3764 7 frequency frequency NN cord-335975-m6lkrehi 3764 8 - - HYPH cord-335975-m6lkrehi 3764 9 less less JJR cord-335975-m6lkrehi 3764 10 than than IN cord-335975-m6lkrehi 3764 11 25 25 CD cord-335975-m6lkrehi 3764 12 % % NN cord-335975-m6lkrehi 3764 13 , , , cord-335975-m6lkrehi 3764 14 between between IN cord-335975-m6lkrehi 3764 15 25 25 CD cord-335975-m6lkrehi 3764 16 and and CC cord-335975-m6lkrehi 3764 17 50 50 CD cord-335975-m6lkrehi 3764 18 % % NN cord-335975-m6lkrehi 3764 19 , , , cord-335975-m6lkrehi 3764 20 between between IN cord-335975-m6lkrehi 3764 21 50 50 CD cord-335975-m6lkrehi 3764 22 and and CC cord-335975-m6lkrehi 3764 23 75 75 CD cord-335975-m6lkrehi 3764 24 % % NN cord-335975-m6lkrehi 3764 25 or or CC cord-335975-m6lkrehi 3764 26 more more JJR cord-335975-m6lkrehi 3764 27 than than IN cord-335975-m6lkrehi 3764 28 75 75 CD cord-335975-m6lkrehi 3764 29 % % NN cord-335975-m6lkrehi 3764 30 of of IN cord-335975-m6lkrehi 3764 31 ICU ICU NNP cord-335975-m6lkrehi 3764 32 days day NNS cord-335975-m6lkrehi 3764 33 . . . cord-335975-m6lkrehi 3765 1 We -PRON- PRP cord-335975-m6lkrehi 3765 2 also also RB cord-335975-m6lkrehi 3765 3 tested test VBD cord-335975-m6lkrehi 3765 4 the the DT cord-335975-m6lkrehi 3765 5 former former JJ cord-335975-m6lkrehi 3765 6 constipation constipation NN cord-335975-m6lkrehi 3765 7 definition definition NN cord-335975-m6lkrehi 3765 8 of of IN cord-335975-m6lkrehi 3765 9 more more JJR cord-335975-m6lkrehi 3765 10 than than IN cord-335975-m6lkrehi 3765 11 6 6 CD cord-335975-m6lkrehi 3765 12 days day NNS cord-335975-m6lkrehi 3765 13 after after IN cord-335975-m6lkrehi 3765 14 admission admission NN cord-335975-m6lkrehi 3765 15 without without IN cord-335975-m6lkrehi 3765 16 stool stool NN cord-335975-m6lkrehi 3765 17 passage passage NN cord-335975-m6lkrehi 3765 18 . . . cord-335975-m6lkrehi 3766 1 We -PRON- PRP cord-335975-m6lkrehi 3766 2 registered register VBD cord-335975-m6lkrehi 3766 3 demographic demographic JJ cord-335975-m6lkrehi 3766 4 data datum NNS cord-335975-m6lkrehi 3766 5 , , , cord-335975-m6lkrehi 3766 6 time time NN cord-335975-m6lkrehi 3766 7 spent spend VBN cord-335975-m6lkrehi 3766 8 under under IN cord-335975-m6lkrehi 3766 9 mechanical mechanical JJ cord-335975-m6lkrehi 3766 10 ventilation ventilation NN cord-335975-m6lkrehi 3766 11 ( ( -LRB- cord-335975-m6lkrehi 3766 12 MV MV NNP cord-335975-m6lkrehi 3766 13 ) ) -RRB- cord-335975-m6lkrehi 3766 14 , , , cord-335975-m6lkrehi 3766 15 ICU ICU NNP cord-335975-m6lkrehi 3766 16 LOS LOS NNP cord-335975-m6lkrehi 3766 17 , , , cord-335975-m6lkrehi 3766 18 ventilation ventilation NN cord-335975-m6lkrehi 3766 19 associated associate VBN cord-335975-m6lkrehi 3766 20 pneumoniae pneumoniae NN cord-335975-m6lkrehi 3766 21 ( ( -LRB- cord-335975-m6lkrehi 3766 22 VAP VAP NNP cord-335975-m6lkrehi 3766 23 ) ) -RRB- cord-335975-m6lkrehi 3766 24 and and CC cord-335975-m6lkrehi 3766 25 vital vital JJ cord-335975-m6lkrehi 3766 26 status status NN cord-335975-m6lkrehi 3766 27 at at IN cord-335975-m6lkrehi 3766 28 discharge discharge NN cord-335975-m6lkrehi 3766 29 . . . cord-335975-m6lkrehi 3767 1 Results result NNS cord-335975-m6lkrehi 3767 2 : : : cord-335975-m6lkrehi 3768 1 Over over IN cord-335975-m6lkrehi 3768 2 10 10 CD cord-335975-m6lkrehi 3768 3 months month NNS cord-335975-m6lkrehi 3768 4 , , , cord-335975-m6lkrehi 3768 5 421 421 CD cord-335975-m6lkrehi 3768 6 patients patient NNS cord-335975-m6lkrehi 3768 7 were be VBD cord-335975-m6lkrehi 3768 8 screened screen VBN cord-335975-m6lkrehi 3768 9 and and CC cord-335975-m6lkrehi 3768 10 141 141 CD cord-335975-m6lkrehi 3768 11 ( ( -LRB- cord-335975-m6lkrehi 3768 12 33.5 33.5 CD cord-335975-m6lkrehi 3768 13 % % NN cord-335975-m6lkrehi 3768 14 ) ) -RRB- cord-335975-m6lkrehi 3768 15 were be VBD cord-335975-m6lkrehi 3768 16 included include VBN cord-335975-m6lkrehi 3768 17 , , , cord-335975-m6lkrehi 3768 18 age age NN cord-335975-m6lkrehi 3768 19 64.6 64.6 CD cord-335975-m6lkrehi 3768 20 ± ± CD cord-335975-m6lkrehi 3768 21 16.7 16.7 CD cord-335975-m6lkrehi 3768 22 years year NNS cord-335975-m6lkrehi 3768 23 , , , cord-335975-m6lkrehi 3769 1 mean mean VBP cord-335975-m6lkrehi 3769 2 SAPS SAPS NNP cord-335975-m6lkrehi 3769 3 II II NNP cord-335975-m6lkrehi 3769 4 45 45 CD cord-335975-m6lkrehi 3769 5 ± ± NNP cord-335975-m6lkrehi 3769 6 17 17 CD cord-335975-m6lkrehi 3769 7 , , , cord-335975-m6lkrehi 3769 8 71 71 CD cord-335975-m6lkrehi 3769 9 ( ( -LRB- cord-335975-m6lkrehi 3769 10 50.3 50.3 CD cord-335975-m6lkrehi 3769 11 % % NN cord-335975-m6lkrehi 3769 12 ) ) -RRB- cord-335975-m6lkrehi 3769 13 mechanically mechanically RB cord-335975-m6lkrehi 3769 14 ventilated ventilate VBN cord-335975-m6lkrehi 3769 15 . . . cord-335975-m6lkrehi 3770 1 The the DT cord-335975-m6lkrehi 3770 2 most most RBS cord-335975-m6lkrehi 3770 3 frequent frequent JJ cord-335975-m6lkrehi 3770 4 exclusion exclusion NN cord-335975-m6lkrehi 3770 5 criteria criterion NNS cord-335975-m6lkrehi 3770 6 were be VBD cord-335975-m6lkrehi 3770 7 LOS LOS NNP cord-335975-m6lkrehi 3770 8 < < XX cord-335975-m6lkrehi 3770 9 72 72 CD cord-335975-m6lkrehi 3770 10 h h NN cord-335975-m6lkrehi 3770 11 ( ( -LRB- cord-335975-m6lkrehi 3770 12 n n NN cord-335975-m6lkrehi 3770 13 = = SYM cord-335975-m6lkrehi 3770 14 140 140 CD cord-335975-m6lkrehi 3770 15 ) ) -RRB- cord-335975-m6lkrehi 3770 16 . . . cord-335975-m6lkrehi 3771 1 68 68 CD cord-335975-m6lkrehi 3771 2 % % NN cord-335975-m6lkrehi 3771 3 of of IN cord-335975-m6lkrehi 3771 4 the the DT cord-335975-m6lkrehi 3771 5 patients patient NNS cord-335975-m6lkrehi 3771 6 had have VBD cord-335975-m6lkrehi 3771 7 stool stool NN cord-335975-m6lkrehi 3771 8 less less JJR cord-335975-m6lkrehi 3771 9 than than IN cord-335975-m6lkrehi 3771 10 50 50 CD cord-335975-m6lkrehi 3771 11 % % NN cord-335975-m6lkrehi 3771 12 of of IN cord-335975-m6lkrehi 3771 13 ICU ICU NNP cord-335975-m6lkrehi 3771 14 days day NNS cord-335975-m6lkrehi 3771 15 . . . cord-335975-m6lkrehi 3772 1 Patients patient NNS cord-335975-m6lkrehi 3772 2 with with IN cord-335975-m6lkrehi 3772 3 fewer few JJR cord-335975-m6lkrehi 3772 4 bowel bowel NN cord-335975-m6lkrehi 3772 5 movements movement NNS cord-335975-m6lkrehi 3772 6 were be VBD cord-335975-m6lkrehi 3772 7 more more RBR cord-335975-m6lkrehi 3772 8 likely likely JJ cord-335975-m6lkrehi 3772 9 to to TO cord-335975-m6lkrehi 3772 10 be be VB cord-335975-m6lkrehi 3772 11 mechanically mechanically RB cord-335975-m6lkrehi 3772 12 ventilated ventilate VBN cord-335975-m6lkrehi 3772 13 , , , cord-335975-m6lkrehi 3772 14 without without IN cord-335975-m6lkrehi 3772 15 association association NN cord-335975-m6lkrehi 3772 16 with with IN cord-335975-m6lkrehi 3772 17 time time NN cord-335975-m6lkrehi 3772 18 spent spend VBN cord-335975-m6lkrehi 3772 19 under under IN cord-335975-m6lkrehi 3772 20 MV MV NNP cord-335975-m6lkrehi 3772 21 . . . cord-335975-m6lkrehi 3773 1 There there EX cord-335975-m6lkrehi 3773 2 was be VBD cord-335975-m6lkrehi 3773 3 a a DT cord-335975-m6lkrehi 3773 4 link link NN cord-335975-m6lkrehi 3773 5 between between IN cord-335975-m6lkrehi 3773 6 the the DT cord-335975-m6lkrehi 3773 7 time time NN cord-335975-m6lkrehi 3773 8 to to IN cord-335975-m6lkrehi 3773 9 first first JJ cord-335975-m6lkrehi 3773 10 stool stool NN cord-335975-m6lkrehi 3773 11 after after IN cord-335975-m6lkrehi 3773 12 admission admission NN cord-335975-m6lkrehi 3773 13 and and CC cord-335975-m6lkrehi 3773 14 the the DT cord-335975-m6lkrehi 3773 15 stool stool NN cord-335975-m6lkrehi 3773 16 frequency frequency NN cord-335975-m6lkrehi 3773 17 during during IN cord-335975-m6lkrehi 3773 18 ICU ICU NNP cord-335975-m6lkrehi 3773 19 ( ( -LRB- cord-335975-m6lkrehi 3773 20 p p NN cord-335975-m6lkrehi 3773 21 < < XX cord-335975-m6lkrehi 3773 22 0.0001 0.0001 CD cord-335975-m6lkrehi 3773 23 VAP VAP NNP cord-335975-m6lkrehi 3773 24 n(% n(% -RRB- cord-335975-m6lkrehi 3773 25 ) ) -RRB- cord-335975-m6lkrehi 3773 26 4 4 CD cord-335975-m6lkrehi 3773 27 ( ( -LRB- cord-335975-m6lkrehi 3773 28 9.5 9.5 CD cord-335975-m6lkrehi 3773 29 ) ) -RRB- cord-335975-m6lkrehi 3773 30 6 6 CD cord-335975-m6lkrehi 3773 31 ( ( -LRB- cord-335975-m6lkrehi 3773 32 11.1 11.1 CD cord-335975-m6lkrehi 3773 33 ) ) -RRB- cord-335975-m6lkrehi 3773 34 2 2 CD cord-335975-m6lkrehi 3773 35 ( ( -LRB- cord-335975-m6lkrehi 3773 36 6.1 6.1 CD cord-335975-m6lkrehi 3773 37 ) ) -RRB- cord-335975-m6lkrehi 3773 38 2 2 CD cord-335975-m6lkrehi 3773 39 ( ( -LRB- cord-335975-m6lkrehi 3773 40 16.7 16.7 CD cord-335975-m6lkrehi 3773 41 ) ) -RRB- cord-335975-m6lkrehi 3773 42 Death death NN cord-335975-m6lkrehi 3773 43 n(% n(% -RRB- cord-335975-m6lkrehi 3773 44 ) ) -RRB- cord-335975-m6lkrehi 3773 45 4 4 CD cord-335975-m6lkrehi 3773 46 ( ( -LRB- cord-335975-m6lkrehi 3773 47 9.5 9.5 CD cord-335975-m6lkrehi 3773 48 ) ) -RRB- cord-335975-m6lkrehi 3773 49 3 3 CD cord-335975-m6lkrehi 3773 50 ( ( -LRB- cord-335975-m6lkrehi 3773 51 5.5 5.5 CD cord-335975-m6lkrehi 3773 52 ) ) -RRB- cord-335975-m6lkrehi 3773 53 5 5 CD cord-335975-m6lkrehi 3773 54 ( ( -LRB- cord-335975-m6lkrehi 3773 55 15.2 15.2 CD cord-335975-m6lkrehi 3773 56 ) ) -RRB- cord-335975-m6lkrehi 3773 57 1 1 CD cord-335975-m6lkrehi 3773 58 ( ( -LRB- cord-335975-m6lkrehi 3773 59 8.3 8.3 CD cord-335975-m6lkrehi 3773 60 ) ) -RRB- cord-335975-m6lkrehi 3773 61 Discussion discussion NN cord-335975-m6lkrehi 3773 62 : : : cord-335975-m6lkrehi 3774 1 This this DT cord-335975-m6lkrehi 3774 2 study study NN cord-335975-m6lkrehi 3774 3 is be VBZ cord-335975-m6lkrehi 3774 4 limited limit VBN cord-335975-m6lkrehi 3774 5 by by IN cord-335975-m6lkrehi 3774 6 the the DT cord-335975-m6lkrehi 3774 7 number number NN cord-335975-m6lkrehi 3774 8 of of IN cord-335975-m6lkrehi 3774 9 patients patient NNS cord-335975-m6lkrehi 3774 10 leading lead VBG cord-335975-m6lkrehi 3774 11 to to IN cord-335975-m6lkrehi 3774 12 an an DT cord-335975-m6lkrehi 3774 13 imbalance imbalance NN cord-335975-m6lkrehi 3774 14 between between IN cord-335975-m6lkrehi 3774 15 subgroups subgroup NNS cord-335975-m6lkrehi 3774 16 therefore therefore RB cord-335975-m6lkrehi 3774 17 limiting limit VBG cord-335975-m6lkrehi 3774 18 the the DT cord-335975-m6lkrehi 3774 19 comparison comparison NN cord-335975-m6lkrehi 3774 20 . . . cord-335975-m6lkrehi 3775 1 Conclusion conclusion NN cord-335975-m6lkrehi 3775 2 : : : cord-335975-m6lkrehi 3776 1 These these DT cord-335975-m6lkrehi 3776 2 preliminary preliminary JJ cord-335975-m6lkrehi 3776 3 results result NNS cord-335975-m6lkrehi 3776 4 do do VBP cord-335975-m6lkrehi 3776 5 not not RB cord-335975-m6lkrehi 3776 6 plead plead VB cord-335975-m6lkrehi 3776 7 for for IN cord-335975-m6lkrehi 3776 8 an an DT cord-335975-m6lkrehi 3776 9 improvement improvement NN cord-335975-m6lkrehi 3776 10 of of IN cord-335975-m6lkrehi 3776 11 the the DT cord-335975-m6lkrehi 3776 12 late late JJ cord-335975-m6lkrehi 3776 13 transit transit NN cord-335975-m6lkrehi 3776 14 definition definition NN cord-335975-m6lkrehi 3776 15 based base VBN cord-335975-m6lkrehi 3776 16 on on IN cord-335975-m6lkrehi 3776 17 the the DT cord-335975-m6lkrehi 3776 18 frequency frequency NN cord-335975-m6lkrehi 3776 19 of of IN cord-335975-m6lkrehi 3776 20 stool stool NN cord-335975-m6lkrehi 3776 21 . . . cord-335975-m6lkrehi 3777 1 Further further JJ cord-335975-m6lkrehi 3777 2 data datum NNS cord-335975-m6lkrehi 3777 3 is be VBZ cord-335975-m6lkrehi 3777 4 warranted warrant VBN cord-335975-m6lkrehi 3777 5 to to TO cord-335975-m6lkrehi 3777 6 better better RB cord-335975-m6lkrehi 3777 7 define define VB cord-335975-m6lkrehi 3777 8 this this DT cord-335975-m6lkrehi 3777 9 condition condition NN cord-335975-m6lkrehi 3777 10 , , , cord-335975-m6lkrehi 3777 11 and and CC cord-335975-m6lkrehi 3777 12 the the DT cord-335975-m6lkrehi 3777 13 management management NN cord-335975-m6lkrehi 3777 14 to to TO cord-335975-m6lkrehi 3777 15 provide provide VB cord-335975-m6lkrehi 3777 16 . . . cord-335975-m6lkrehi 3778 1 Introduction introduction NN cord-335975-m6lkrehi 3778 2 : : : cord-335975-m6lkrehi 3778 3 Antibiotic antibiotic JJ cord-335975-m6lkrehi 3778 4 therapy therapy NN cord-335975-m6lkrehi 3778 5 during during IN cord-335975-m6lkrehi 3778 6 acute acute JJ cord-335975-m6lkrehi 3778 7 exacerbation exacerbation NN cord-335975-m6lkrehi 3778 8 of of IN cord-335975-m6lkrehi 3778 9 COPD COPD NNP cord-335975-m6lkrehi 3778 10 ( ( -LRB- cord-335975-m6lkrehi 3778 11 AECOPD AECOPD NNP cord-335975-m6lkrehi 3778 12 ) ) -RRB- cord-335975-m6lkrehi 3778 13 still still RB cord-335975-m6lkrehi 3778 14 controversial controversial JJ cord-335975-m6lkrehi 3778 15 and and CC cord-335975-m6lkrehi 3778 16 not not RB cord-335975-m6lkrehi 3778 17 well well RB cord-335975-m6lkrehi 3778 18 supported support VBN cord-335975-m6lkrehi 3778 19 by by IN cord-335975-m6lkrehi 3778 20 clinical clinical JJ cord-335975-m6lkrehi 3778 21 evidence evidence NN cord-335975-m6lkrehi 3778 22 . . . cord-335975-m6lkrehi 3779 1 In in IN cord-335975-m6lkrehi 3779 2 fact fact NN cord-335975-m6lkrehi 3779 3 half half NN cord-335975-m6lkrehi 3779 4 of of IN cord-335975-m6lkrehi 3779 5 these these DT cord-335975-m6lkrehi 3779 6 episodes episode NNS cord-335975-m6lkrehi 3779 7 are be VBP cord-335975-m6lkrehi 3779 8 caused cause VBN cord-335975-m6lkrehi 3779 9 by by IN cord-335975-m6lkrehi 3779 10 viruses virus NNS cord-335975-m6lkrehi 3779 11 even even RB cord-335975-m6lkrehi 3779 12 during during IN cord-335975-m6lkrehi 3779 13 severe severe JJ cord-335975-m6lkrehi 3779 14 episodes episode NNS cord-335975-m6lkrehi 3779 15 with with IN cord-335975-m6lkrehi 3779 16 need need NN cord-335975-m6lkrehi 3779 17 to to TO cord-335975-m6lkrehi 3779 18 ventilator ventilator NN cord-335975-m6lkrehi 3779 19 support support NN cord-335975-m6lkrehi 3779 20 . . . cord-335975-m6lkrehi 3780 1 Procalcitonin Procalcitonin NNP cord-335975-m6lkrehi 3780 2 is be VBZ cord-335975-m6lkrehi 3780 3 effective effective JJ cord-335975-m6lkrehi 3780 4 to to TO cord-335975-m6lkrehi 3780 5 guide guide VB cord-335975-m6lkrehi 3780 6 antibiotic antibiotic JJ cord-335975-m6lkrehi 3780 7 therapy therapy NN cord-335975-m6lkrehi 3780 8 during during IN cord-335975-m6lkrehi 3780 9 acute acute JJ cord-335975-m6lkrehi 3780 10 exacerbation exacerbation NN cord-335975-m6lkrehi 3780 11 of of IN cord-335975-m6lkrehi 3780 12 COPD COPD NNP cord-335975-m6lkrehi 3780 13 without without IN cord-335975-m6lkrehi 3780 14 compromising compromise VBG cord-335975-m6lkrehi 3780 15 patients patient NNS cord-335975-m6lkrehi 3780 16 ' ' POS cord-335975-m6lkrehi 3780 17 outcome outcome NN cord-335975-m6lkrehi 3780 18 , , , cord-335975-m6lkrehi 3780 19 its -PRON- PRP$ cord-335975-m6lkrehi 3780 20 efficacy efficacy NN cord-335975-m6lkrehi 3780 21 in in IN cord-335975-m6lkrehi 3780 22 the the DT cord-335975-m6lkrehi 3780 23 intensive intensive JJ cord-335975-m6lkrehi 3780 24 care care NN cord-335975-m6lkrehi 3780 25 setting set VBG cord-335975-m6lkrehi 3780 26 still still RB cord-335975-m6lkrehi 3780 27 not not RB cord-335975-m6lkrehi 3780 28 well well RB cord-335975-m6lkrehi 3780 29 evaluated evaluate VBN cord-335975-m6lkrehi 3780 30 . . . cord-335975-m6lkrehi 3781 1 We -PRON- PRP cord-335975-m6lkrehi 3781 2 have have VBP cord-335975-m6lkrehi 3781 3 conducted conduct VBN cord-335975-m6lkrehi 3781 4 in in IN cord-335975-m6lkrehi 3781 5 a a DT cord-335975-m6lkrehi 3781 6 10 10 CD cord-335975-m6lkrehi 3781 7 bed bed NN cord-335975-m6lkrehi 3781 8 ICU ICU NNP cord-335975-m6lkrehi 3781 9 a a DT cord-335975-m6lkrehi 3781 10 before before RB cord-335975-m6lkrehi 3781 11 after after IN cord-335975-m6lkrehi 3781 12 study study NN cord-335975-m6lkrehi 3781 13 . . . cord-335975-m6lkrehi 3782 1 During during IN cord-335975-m6lkrehi 3782 2 the the DT cord-335975-m6lkrehi 3782 3 first first JJ cord-335975-m6lkrehi 3782 4 period period NN cord-335975-m6lkrehi 3782 5 ( ( -LRB- cord-335975-m6lkrehi 3782 6 January January NNP cord-335975-m6lkrehi 3782 7 2012-December 2012-december CD cord-335975-m6lkrehi 3782 8 2013 2013 CD cord-335975-m6lkrehi 3782 9 ) ) -RRB- cord-335975-m6lkrehi 3782 10 patients patient NNS cord-335975-m6lkrehi 3782 11 with with IN cord-335975-m6lkrehi 3782 12 AECOPD AECOPD NNP cord-335975-m6lkrehi 3782 13 were be VBD cord-335975-m6lkrehi 3782 14 included include VBN cord-335975-m6lkrehi 3782 15 retrospectively retrospectively RB cord-335975-m6lkrehi 3782 16 and and CC cord-335975-m6lkrehi 3782 17 treated treat VBN cord-335975-m6lkrehi 3782 18 with with IN cord-335975-m6lkrehi 3782 19 antibiotics antibiotic NNS cord-335975-m6lkrehi 3782 20 according accord VBG cord-335975-m6lkrehi 3782 21 to to IN cord-335975-m6lkrehi 3782 22 Anthonisen Anthonisen NNP cord-335975-m6lkrehi 3782 23 criteria criterion NNS cord-335975-m6lkrehi 3782 24 ( ( -LRB- cord-335975-m6lkrehi 3782 25 control control NN cord-335975-m6lkrehi 3782 26 group group NN cord-335975-m6lkrehi 3782 27 ) ) -RRB- cord-335975-m6lkrehi 3782 28 . . . cord-335975-m6lkrehi 3783 1 In in IN cord-335975-m6lkrehi 3783 2 the the DT cord-335975-m6lkrehi 3783 3 second second JJ cord-335975-m6lkrehi 3783 4 period period NN cord-335975-m6lkrehi 3783 5 ( ( -LRB- cord-335975-m6lkrehi 3783 6 January January NNP cord-335975-m6lkrehi 3783 7 2014-May 2014-may CD cord-335975-m6lkrehi 3783 8 2017 2017 CD cord-335975-m6lkrehi 3783 9 ) ) -RRB- cord-335975-m6lkrehi 3783 10 antibiotics antibiotic NNS cord-335975-m6lkrehi 3783 11 were be VBD cord-335975-m6lkrehi 3783 12 prescribed prescribe VBN cord-335975-m6lkrehi 3783 13 only only RB cord-335975-m6lkrehi 3783 14 if if IN cord-335975-m6lkrehi 3783 15 the the DT cord-335975-m6lkrehi 3783 16 Procalcitonin Procalcitonin NNP cord-335975-m6lkrehi 3783 17 level level NN cord-335975-m6lkrehi 3783 18 was be VBD cord-335975-m6lkrehi 3783 19 greater great JJR cord-335975-m6lkrehi 3783 20 than than IN cord-335975-m6lkrehi 3783 21 0.25 0.25 CD cord-335975-m6lkrehi 3783 22 ng ng NN cord-335975-m6lkrehi 3783 23 ml ml NNP cord-335975-m6lkrehi 3783 24 ( ( -LRB- cord-335975-m6lkrehi 3783 25 procalcitonin procalcitonin NNP cord-335975-m6lkrehi 3783 26 group group NN cord-335975-m6lkrehi 3783 27 ) ) -RRB- cord-335975-m6lkrehi 3783 28 . . . cord-335975-m6lkrehi 3784 1 Results result NNS cord-335975-m6lkrehi 3784 2 : : : cord-335975-m6lkrehi 3785 1 Ninety ninety CD cord-335975-m6lkrehi 3785 2 - - HYPH cord-335975-m6lkrehi 3785 3 two two CD cord-335975-m6lkrehi 3785 4 patients patient NNS cord-335975-m6lkrehi 3785 5 were be VBD cord-335975-m6lkrehi 3785 6 included include VBN cord-335975-m6lkrehi 3785 7 , , , cord-335975-m6lkrehi 3785 8 41 41 CD cord-335975-m6lkrehi 3785 9 in in IN cord-335975-m6lkrehi 3785 10 the the DT cord-335975-m6lkrehi 3785 11 Procalcitonin Procalcitonin NNP cord-335975-m6lkrehi 3785 12 group group NN cord-335975-m6lkrehi 3785 13 and and CC cord-335975-m6lkrehi 3785 14 52 52 CD cord-335975-m6lkrehi 3785 15 in in IN cord-335975-m6lkrehi 3785 16 the the DT cord-335975-m6lkrehi 3785 17 control control NN cord-335975-m6lkrehi 3785 18 group group NN cord-335975-m6lkrehi 3785 19 . . . cord-335975-m6lkrehi 3786 1 Antibiotics antibiotic NNS cord-335975-m6lkrehi 3786 2 were be VBD cord-335975-m6lkrehi 3786 3 administered administer VBN cord-335975-m6lkrehi 3786 4 at at IN cord-335975-m6lkrehi 3786 5 ICU ICU NNP cord-335975-m6lkrehi 3786 6 admission admission NN cord-335975-m6lkrehi 3786 7 in in IN cord-335975-m6lkrehi 3786 8 7 7 CD cord-335975-m6lkrehi 3786 9 patients patient NNS cord-335975-m6lkrehi 3786 10 ( ( -LRB- cord-335975-m6lkrehi 3786 11 17 17 CD cord-335975-m6lkrehi 3786 12 % % NN cord-335975-m6lkrehi 3786 13 ) ) -RRB- cord-335975-m6lkrehi 3786 14 in in IN cord-335975-m6lkrehi 3786 15 the the DT cord-335975-m6lkrehi 3786 16 procalcitonin procalcitonin NNP cord-335975-m6lkrehi 3786 17 group group NN cord-335975-m6lkrehi 3786 18 and and CC cord-335975-m6lkrehi 3786 19 in in IN cord-335975-m6lkrehi 3786 20 27 27 CD cord-335975-m6lkrehi 3786 21 ( ( -LRB- cord-335975-m6lkrehi 3786 22 52 52 CD cord-335975-m6lkrehi 3786 23 % % NN cord-335975-m6lkrehi 3786 24 ) ) -RRB- cord-335975-m6lkrehi 3786 25 patients patient NNS cord-335975-m6lkrehi 3786 26 in in IN cord-335975-m6lkrehi 3786 27 the the DT cord-335975-m6lkrehi 3786 28 control control NN cord-335975-m6lkrehi 3786 29 group group NN cord-335975-m6lkrehi 3786 30 , , , cord-335975-m6lkrehi 3786 31 p p NN cord-335975-m6lkrehi 3786 32 = = SYM cord-335975-m6lkrehi 3786 33 0.001 0.001 CD cord-335975-m6lkrehi 3786 34 . . . cord-335975-m6lkrehi 3787 1 Only only RB cord-335975-m6lkrehi 3787 2 10 10 CD cord-335975-m6lkrehi 3787 3 % % NN cord-335975-m6lkrehi 3787 4 of of IN cord-335975-m6lkrehi 3787 5 sputum sputum NN cord-335975-m6lkrehi 3787 6 cultures culture NNS cord-335975-m6lkrehi 3787 7 were be VBD cord-335975-m6lkrehi 3787 8 positive positive JJ cord-335975-m6lkrehi 3787 9 at at IN cord-335975-m6lkrehi 3787 10 ICU ICU NNP cord-335975-m6lkrehi 3787 11 admission admission NN cord-335975-m6lkrehi 3787 12 . . . cord-335975-m6lkrehi 3788 1 Time time NN cord-335975-m6lkrehi 3788 2 to to IN cord-335975-m6lkrehi 3788 3 recovery recovery NN cord-335975-m6lkrehi 3788 4 was be VBD cord-335975-m6lkrehi 3788 5 similar similar JJ cord-335975-m6lkrehi 3788 6 between between IN cord-335975-m6lkrehi 3788 7 the the DT cord-335975-m6lkrehi 3788 8 two two CD cord-335975-m6lkrehi 3788 9 groups group NNS cord-335975-m6lkrehi 3788 10 [ [ -LRB- cord-335975-m6lkrehi 3788 11 7 7 CD cord-335975-m6lkrehi 3788 12 IQR IQR NNP cord-335975-m6lkrehi 3788 13 ( ( -LRB- cord-335975-m6lkrehi 3788 14 3 3 CD cord-335975-m6lkrehi 3788 15 ) ) -RRB- cord-335975-m6lkrehi 3788 16 ( ( -LRB- cord-335975-m6lkrehi 3788 17 4 4 LS cord-335975-m6lkrehi 3788 18 ) ) -RRB- cord-335975-m6lkrehi 3788 19 ( ( -LRB- cord-335975-m6lkrehi 3788 20 5 5 LS cord-335975-m6lkrehi 3788 21 ) ) -RRB- cord-335975-m6lkrehi 3788 22 ( ( -LRB- cord-335975-m6lkrehi 3788 23 6 6 LS cord-335975-m6lkrehi 3788 24 ) ) -RRB- cord-335975-m6lkrehi 3788 25 ( ( -LRB- cord-335975-m6lkrehi 3788 26 7 7 LS cord-335975-m6lkrehi 3788 27 ) ) -RRB- cord-335975-m6lkrehi 3788 28 ( ( -LRB- cord-335975-m6lkrehi 3788 29 8) 8) NNP cord-335975-m6lkrehi 3788 30 ( ( -LRB- cord-335975-m6lkrehi 3788 31 9 9 CD cord-335975-m6lkrehi 3788 32 ) ) -RRB- cord-335975-m6lkrehi 3788 33 ( ( -LRB- cord-335975-m6lkrehi 3788 34 10 10 CD cord-335975-m6lkrehi 3788 35 ) ) -RRB- cord-335975-m6lkrehi 3788 36 ( ( -LRB- cord-335975-m6lkrehi 3788 37 11 11 CD cord-335975-m6lkrehi 3788 38 ) ) -RRB- cord-335975-m6lkrehi 3788 39 ( ( -LRB- cord-335975-m6lkrehi 3788 40 12 12 CD cord-335975-m6lkrehi 3788 41 ) ) -RRB- cord-335975-m6lkrehi 3788 42 ( ( -LRB- cord-335975-m6lkrehi 3788 43 13 13 CD cord-335975-m6lkrehi 3788 44 ) ) -RRB- cord-335975-m6lkrehi 3788 45 ( ( -LRB- cord-335975-m6lkrehi 3788 46 14 14 CD cord-335975-m6lkrehi 3788 47 ) ) -RRB- cord-335975-m6lkrehi 3788 48 , , , cord-335975-m6lkrehi 3788 49 6 6 CD cord-335975-m6lkrehi 3788 50 IQR IQR NNP cord-335975-m6lkrehi 3788 51 ( ( -LRB- cord-335975-m6lkrehi 3788 52 3 3 CD cord-335975-m6lkrehi 3788 53 - - SYM cord-335975-m6lkrehi 3788 54 10 10 CD cord-335975-m6lkrehi 3788 55 ) ) -RRB- cord-335975-m6lkrehi 3788 56 , , , cord-335975-m6lkrehi 3788 57 p p NN cord-335975-m6lkrehi 3788 58 = = SYM cord-335975-m6lkrehi 3788 59 0.48 0.48 CD cord-335975-m6lkrehi 3788 60 ] ] -RRB- cord-335975-m6lkrehi 3788 61 . . . cord-335975-m6lkrehi 3789 1 Other other JJ cord-335975-m6lkrehi 3789 2 patients patient NNS cord-335975-m6lkrehi 3789 3 ' ' POS cord-335975-m6lkrehi 3789 4 outcomes outcome NNS cord-335975-m6lkrehi 3789 5 did do VBD cord-335975-m6lkrehi 3789 6 not not RB cord-335975-m6lkrehi 3789 7 differ differ VB cord-335975-m6lkrehi 3789 8 between between IN cord-335975-m6lkrehi 3789 9 the the DT cord-335975-m6lkrehi 3789 10 control control NN cord-335975-m6lkrehi 3789 11 group group NN cord-335975-m6lkrehi 3789 12 and and CC cord-335975-m6lkrehi 3789 13 the the DT cord-335975-m6lkrehi 3789 14 procalcitonin procalcitonin NNP cord-335975-m6lkrehi 3789 15 group group NN cord-335975-m6lkrehi 3789 16 with with IN cord-335975-m6lkrehi 3789 17 respectively respectively RB cord-335975-m6lkrehi 3789 18 : : : cord-335975-m6lkrehi 3789 19 the the DT cord-335975-m6lkrehi 3789 20 mortality mortality NN cord-335975-m6lkrehi 3789 21 ( ( -LRB- cord-335975-m6lkrehi 3789 22 9.5 9.5 CD cord-335975-m6lkrehi 3789 23 vs. vs. NN cord-335975-m6lkrehi 3789 24 19 19 CD cord-335975-m6lkrehi 3789 25 % % NN cord-335975-m6lkrehi 3789 26 , , , cord-335975-m6lkrehi 3789 27 p p NN cord-335975-m6lkrehi 3789 28 = = SYM cord-335975-m6lkrehi 3789 29 0.17 0.17 CD cord-335975-m6lkrehi 3789 30 ) ) -RRB- cord-335975-m6lkrehi 3789 31 , , , cord-335975-m6lkrehi 3789 32 the the DT cord-335975-m6lkrehi 3789 33 incidence incidence NN cord-335975-m6lkrehi 3789 34 of of IN cord-335975-m6lkrehi 3789 35 PAVM PAVM NNP cord-335975-m6lkrehi 3789 36 ( ( -LRB- cord-335975-m6lkrehi 3789 37 11 11 CD cord-335975-m6lkrehi 3789 38 vs. vs. CC cord-335975-m6lkrehi 3789 39 17 17 CD cord-335975-m6lkrehi 3789 40 % % NN cord-335975-m6lkrehi 3789 41 , , , cord-335975-m6lkrehi 3789 42 p p NN cord-335975-m6lkrehi 3789 43 = = SYM cord-335975-m6lkrehi 3789 44 0.44 0.44 CD cord-335975-m6lkrehi 3789 45 ) ) -RRB- cord-335975-m6lkrehi 3789 46 and and CC cord-335975-m6lkrehi 3789 47 NIV NIV NNP cord-335975-m6lkrehi 3789 48 failure failure NN cord-335975-m6lkrehi 3789 49 ( ( -LRB- cord-335975-m6lkrehi 3789 50 42 42 CD cord-335975-m6lkrehi 3789 51 vs. vs. IN cord-335975-m6lkrehi 3789 52 46 46 CD cord-335975-m6lkrehi 3789 53 % % NN cord-335975-m6lkrehi 3789 54 , , , cord-335975-m6lkrehi 3789 55 p p NN cord-335975-m6lkrehi 3789 56 = = SYM cord-335975-m6lkrehi 3789 57 0.69 0.69 CD cord-335975-m6lkrehi 3789 58 ) ) -RRB- cord-335975-m6lkrehi 3789 59 . . . cord-335975-m6lkrehi 3790 1 Readmission readmission NN cord-335975-m6lkrehi 3790 2 to to IN cord-335975-m6lkrehi 3790 3 the the DT cord-335975-m6lkrehi 3790 4 hospital hospital NN cord-335975-m6lkrehi 3790 5 at at IN cord-335975-m6lkrehi 3790 6 day day NN cord-335975-m6lkrehi 3790 7 90 90 CD cord-335975-m6lkrehi 3790 8 was be VBD cord-335975-m6lkrehi 3790 9 significantly significantly RB cord-335975-m6lkrehi 3790 10 higher high JJR cord-335975-m6lkrehi 3790 11 in in IN cord-335975-m6lkrehi 3790 12 the the DT cord-335975-m6lkrehi 3790 13 control control NN cord-335975-m6lkrehi 3790 14 group group NN cord-335975-m6lkrehi 3790 15 ( ( -LRB- cord-335975-m6lkrehi 3790 16 38 38 CD cord-335975-m6lkrehi 3790 17 vs. vs. CC cord-335975-m6lkrehi 3790 18 17 17 CD cord-335975-m6lkrehi 3790 19 % % NN cord-335975-m6lkrehi 3790 20 , , , cord-335975-m6lkrehi 3790 21 p p NN cord-335975-m6lkrehi 3790 22 = = SYM cord-335975-m6lkrehi 3790 23 0.03 0.03 CD cord-335975-m6lkrehi 3790 24 ) ) -RRB- cord-335975-m6lkrehi 3790 25 . . . cord-335975-m6lkrehi 3791 1 Conclusion conclusion NN cord-335975-m6lkrehi 3791 2 : : : cord-335975-m6lkrehi 3791 3 Using use VBG cord-335975-m6lkrehi 3791 4 Procalcitonin Procalcitonin NNP cord-335975-m6lkrehi 3791 5 to to TO cord-335975-m6lkrehi 3791 6 guide guide VB cord-335975-m6lkrehi 3791 7 antibiotic antibiotic JJ cord-335975-m6lkrehi 3791 8 therapy therapy NN cord-335975-m6lkrehi 3791 9 during during IN cord-335975-m6lkrehi 3791 10 severe severe JJ cord-335975-m6lkrehi 3791 11 AECOPD AECOPD NNP cord-335975-m6lkrehi 3791 12 can can MD cord-335975-m6lkrehi 3791 13 reduce reduce VB cord-335975-m6lkrehi 3791 14 the the DT cord-335975-m6lkrehi 3791 15 use use NN cord-335975-m6lkrehi 3791 16 of of IN cord-335975-m6lkrehi 3791 17 antibiotics antibiotic NNS cord-335975-m6lkrehi 3791 18 without without IN cord-335975-m6lkrehi 3791 19 compromising compromise VBG cord-335975-m6lkrehi 3791 20 patients patient NNS cord-335975-m6lkrehi 3791 21 ' ' POS cord-335975-m6lkrehi 3791 22 outcomes outcome NNS cord-335975-m6lkrehi 3791 23 . . . cord-335975-m6lkrehi 3792 1 Our -PRON- PRP$ cord-335975-m6lkrehi 3792 2 study study NN cord-335975-m6lkrehi 3792 3 aimed aim VBD cord-335975-m6lkrehi 3792 4 to to TO cord-335975-m6lkrehi 3792 5 assess assess VB cord-335975-m6lkrehi 3792 6 whether whether IN cord-335975-m6lkrehi 3792 7 ARC ARC NNP cord-335975-m6lkrehi 3792 8 impacts impact NNS cord-335975-m6lkrehi 3792 9 negatively negatively RB cord-335975-m6lkrehi 3792 10 on on IN cord-335975-m6lkrehi 3792 11 cefazolin cefazolin JJ cord-335975-m6lkrehi 3792 12 pharmacokinetic pharmacokinetic JJ cord-335975-m6lkrehi 3792 13 pharmacodynamics pharmacodynamic NNS cord-335975-m6lkrehi 3792 14 ( ( -LRB- cord-335975-m6lkrehi 3792 15 PK PK NNP cord-335975-m6lkrehi 3792 16 / / SYM cord-335975-m6lkrehi 3792 17 PD PD NNP cord-335975-m6lkrehi 3792 18 ) ) -RRB- cord-335975-m6lkrehi 3792 19 target target VBP cord-335975-m6lkrehi 3792 20 attainment attainment JJ cord-335975-m6lkrehi 3792 21 and and CC cord-335975-m6lkrehi 3792 22 clinical clinical JJ cord-335975-m6lkrehi 3792 23 outcome outcome NN cord-335975-m6lkrehi 3792 24 in in IN cord-335975-m6lkrehi 3792 25 critically critically RB cord-335975-m6lkrehi 3792 26 ill ill JJ cord-335975-m6lkrehi 3792 27 patients patient NNS cord-335975-m6lkrehi 3792 28 . . . cord-335975-m6lkrehi 3793 1 Patients patient NNS cord-335975-m6lkrehi 3793 2 and and CC cord-335975-m6lkrehi 3793 3 methods method NNS cord-335975-m6lkrehi 3793 4 : : : cord-335975-m6lkrehi 3793 5 Over over IN cord-335975-m6lkrehi 3793 6 an an DT cord-335975-m6lkrehi 3793 7 8-month 8-month JJ cord-335975-m6lkrehi 3793 8 period period NN cord-335975-m6lkrehi 3793 9 , , , cord-335975-m6lkrehi 3793 10 all all DT cord-335975-m6lkrehi 3793 11 critically critically RB cord-335975-m6lkrehi 3793 12 ill ill JJ cord-335975-m6lkrehi 3793 13 patients patient NNS cord-335975-m6lkrehi 3793 14 treated treat VBN cord-335975-m6lkrehi 3793 15 by by IN cord-335975-m6lkrehi 3793 16 cefazolin cefazolin NNP cord-335975-m6lkrehi 3793 17 for for IN cord-335975-m6lkrehi 3793 18 a a DT cord-335975-m6lkrehi 3793 19 documented document VBN cord-335975-m6lkrehi 3793 20 respiratory respiratory JJ cord-335975-m6lkrehi 3793 21 infection infection NN cord-335975-m6lkrehi 3793 22 without without IN cord-335975-m6lkrehi 3793 23 renal renal JJ cord-335975-m6lkrehi 3793 24 impairment impairment NN cord-335975-m6lkrehi 3793 25 were be VBD cord-335975-m6lkrehi 3793 26 eligible eligible JJ cord-335975-m6lkrehi 3793 27 . . . cord-335975-m6lkrehi 3794 1 Patients patient NNS cord-335975-m6lkrehi 3794 2 who who WP cord-335975-m6lkrehi 3794 3 underwent undergo VBD cord-335975-m6lkrehi 3794 4 an an DT cord-335975-m6lkrehi 3794 5 empiric empiric JJ cord-335975-m6lkrehi 3794 6 antimicrobial antimicrobial JJ cord-335975-m6lkrehi 3794 7 treatment treatment NN cord-335975-m6lkrehi 3794 8 > > XX cord-335975-m6lkrehi 3794 9 48 48 CD cord-335975-m6lkrehi 3794 10 h h NN cord-335975-m6lkrehi 3794 11 before before IN cord-335975-m6lkrehi 3794 12 introduction introduction NN cord-335975-m6lkrehi 3794 13 of of IN cord-335975-m6lkrehi 3794 14 cefazolin cefazolin NNP cord-335975-m6lkrehi 3794 15 were be VBD cord-335975-m6lkrehi 3794 16 not not RB cord-335975-m6lkrehi 3794 17 included include VBN cord-335975-m6lkrehi 3794 18 . . . cord-335975-m6lkrehi 3795 1 During during IN cord-335975-m6lkrehi 3795 2 the the DT cord-335975-m6lkrehi 3795 3 first first JJ cord-335975-m6lkrehi 3795 4 three three CD cord-335975-m6lkrehi 3795 5 days day NNS cord-335975-m6lkrehi 3795 6 of of IN cord-335975-m6lkrehi 3795 7 antimicrobial antimicrobial JJ cord-335975-m6lkrehi 3795 8 therapy therapy NN cord-335975-m6lkrehi 3795 9 , , , cord-335975-m6lkrehi 3795 10 every every DT cord-335975-m6lkrehi 3795 11 patient patient NN cord-335975-m6lkrehi 3795 12 underwent undergo VBD cord-335975-m6lkrehi 3795 13 24-hour 24-hour JJ cord-335975-m6lkrehi 3795 14 creatinine creatinine NN cord-335975-m6lkrehi 3795 15 clearance clearance NN cord-335975-m6lkrehi 3795 16 ( ( -LRB- cord-335975-m6lkrehi 3795 17 CrCL CrCL NNP cord-335975-m6lkrehi 3795 18 ) ) -RRB- cord-335975-m6lkrehi 3795 19 measurements measurement NNS cord-335975-m6lkrehi 3795 20 and and CC cord-335975-m6lkrehi 3795 21 therapeutic therapeutic JJ cord-335975-m6lkrehi 3795 22 drug drug NN cord-335975-m6lkrehi 3795 23 monitoring monitoring NN cord-335975-m6lkrehi 3795 24 at at IN cord-335975-m6lkrehi 3795 25 steady steady JJ cord-335975-m6lkrehi 3795 26 state state NN cord-335975-m6lkrehi 3795 27 . . . cord-335975-m6lkrehi 3796 1 The the DT cord-335975-m6lkrehi 3796 2 main main JJ cord-335975-m6lkrehi 3796 3 outcome outcome NN cord-335975-m6lkrehi 3796 4 investigated investigate VBN cord-335975-m6lkrehi 3796 5 in in IN cord-335975-m6lkrehi 3796 6 this this DT cord-335975-m6lkrehi 3796 7 study study NN cord-335975-m6lkrehi 3796 8 was be VBD cord-335975-m6lkrehi 3796 9 the the DT cord-335975-m6lkrehi 3796 10 rate rate NN cord-335975-m6lkrehi 3796 11 of of IN cord-335975-m6lkrehi 3796 12 PK PK NNP cord-335975-m6lkrehi 3796 13 PD PD NNP cord-335975-m6lkrehi 3796 14 target target NN cord-335975-m6lkrehi 3796 15 non non JJ cord-335975-m6lkrehi 3796 16 - - JJ cord-335975-m6lkrehi 3796 17 attainment attainment JJ cord-335975-m6lkrehi 3796 18 defined define VBN cord-335975-m6lkrehi 3796 19 by by IN cord-335975-m6lkrehi 3796 20 an an DT cord-335975-m6lkrehi 3796 21 unbound unbound JJ cord-335975-m6lkrehi 3796 22 concentration concentration NN cord-335975-m6lkrehi 3796 23 < < XX cord-335975-m6lkrehi 3797 1 16 16 CD cord-335975-m6lkrehi 3797 2 µg µg NN cord-335975-m6lkrehi 3797 3 ml ml NN cord-335975-m6lkrehi 3797 4 ( ( -LRB- cord-335975-m6lkrehi 3797 5 MIC mic NN cord-335975-m6lkrehi 3797 6 value value NN cord-335975-m6lkrehi 3797 7 for for IN cord-335975-m6lkrehi 3797 8 inoculum inoculum NN cord-335975-m6lkrehi 3797 9 > > XX cord-335975-m6lkrehi 3797 10 10 10 CD cord-335975-m6lkrehi 3797 11 7 7 CD cord-335975-m6lkrehi 3797 12 UFC UFC NNP cord-335975-m6lkrehi 3797 13 ml ml NN cord-335975-m6lkrehi 3797 14 ) ) -RRB- cord-335975-m6lkrehi 3797 15 . . . cord-335975-m6lkrehi 3798 1 The the DT cord-335975-m6lkrehi 3798 2 secondary secondary JJ cord-335975-m6lkrehi 3798 3 outcome outcome NN cord-335975-m6lkrehi 3798 4 was be VBD cord-335975-m6lkrehi 3798 5 the the DT cord-335975-m6lkrehi 3798 6 rate rate NN cord-335975-m6lkrehi 3798 7 of of IN cord-335975-m6lkrehi 3798 8 therapeutic therapeutic JJ cord-335975-m6lkrehi 3798 9 failure failure NN cord-335975-m6lkrehi 3798 10 , , , cord-335975-m6lkrehi 3798 11 defined define VBN cord-335975-m6lkrehi 3798 12 as as IN cord-335975-m6lkrehi 3798 13 an an DT cord-335975-m6lkrehi 3798 14 impaired impaired JJ cord-335975-m6lkrehi 3798 15 clinical clinical JJ cord-335975-m6lkrehi 3798 16 response response NN cord-335975-m6lkrehi 3798 17 with with IN cord-335975-m6lkrehi 3798 18 a a DT cord-335975-m6lkrehi 3798 19 need need NN cord-335975-m6lkrehi 3798 20 for for IN cord-335975-m6lkrehi 3798 21 escalating escalate VBG cord-335975-m6lkrehi 3798 22 antibiotics antibiotic NNS cord-335975-m6lkrehi 3798 23 during during IN cord-335975-m6lkrehi 3798 24 treatment treatment NN cord-335975-m6lkrehi 3798 25 and and CC cord-335975-m6lkrehi 3798 26 or or CC cord-335975-m6lkrehi 3798 27 within within IN cord-335975-m6lkrehi 3798 28 15 15 CD cord-335975-m6lkrehi 3798 29 days day NNS cord-335975-m6lkrehi 3798 30 after after IN cord-335975-m6lkrehi 3798 31 end end NN cord-335975-m6lkrehi 3798 32 - - HYPH cord-335975-m6lkrehi 3798 33 of of IN cord-335975-m6lkrehi 3798 34 - - HYPH cord-335975-m6lkrehi 3798 35 treatment treatment NN cord-335975-m6lkrehi 3798 36 . . . cord-335975-m6lkrehi 3799 1 Results result NNS cord-335975-m6lkrehi 3799 2 : : : cord-335975-m6lkrehi 3800 1 Over over IN cord-335975-m6lkrehi 3800 2 the the DT cord-335975-m6lkrehi 3800 3 study study NN cord-335975-m6lkrehi 3800 4 period period NN cord-335975-m6lkrehi 3800 5 , , , cord-335975-m6lkrehi 3800 6 11 11 CD cord-335975-m6lkrehi 3800 7 patients patient NNS cord-335975-m6lkrehi 3800 8 were be VBD cord-335975-m6lkrehi 3800 9 included include VBN cord-335975-m6lkrehi 3800 10 ( ( -LRB- cord-335975-m6lkrehi 3800 11 33 33 CD cord-335975-m6lkrehi 3800 12 samples sample NNS cord-335975-m6lkrehi 3800 13 analyzed analyze VBN cord-335975-m6lkrehi 3800 14 for for IN cord-335975-m6lkrehi 3800 15 therapeutic therapeutic JJ cord-335975-m6lkrehi 3800 16 drug drug NN cord-335975-m6lkrehi 3800 17 monitoring monitoring NN cord-335975-m6lkrehi 3800 18 ) ) -RRB- cord-335975-m6lkrehi 3800 19 . . . cord-335975-m6lkrehi 3801 1 In in IN cord-335975-m6lkrehi 3801 2 pharmacological pharmacological JJ cord-335975-m6lkrehi 3801 3 analysis analysis NN cord-335975-m6lkrehi 3801 4 , , , cord-335975-m6lkrehi 3801 5 the the DT cord-335975-m6lkrehi 3801 6 rate rate NN cord-335975-m6lkrehi 3801 7 of of IN cord-335975-m6lkrehi 3801 8 PK PK NNP cord-335975-m6lkrehi 3801 9 PD PD NNP cord-335975-m6lkrehi 3801 10 target target NN cord-335975-m6lkrehi 3801 11 non non JJ cord-335975-m6lkrehi 3801 12 - - JJ cord-335975-m6lkrehi 3801 13 attainment attainment JJ cord-335975-m6lkrehi 3801 14 was be VBD cord-335975-m6lkrehi 3801 15 64 64 CD cord-335975-m6lkrehi 3801 16 % % NN cord-335975-m6lkrehi 3801 17 , , , cord-335975-m6lkrehi 3801 18 with with IN cord-335975-m6lkrehi 3801 19 a a DT cord-335975-m6lkrehi 3801 20 strong strong JJ cord-335975-m6lkrehi 3801 21 association association NN cord-335975-m6lkrehi 3801 22 with with IN cord-335975-m6lkrehi 3801 23 CrCL CrCL NNP cord-335975-m6lkrehi 3801 24 ( ( -LRB- cord-335975-m6lkrehi 3801 25 p p NN cord-335975-m6lkrehi 3801 26 = = SYM cord-335975-m6lkrehi 3801 27 0.001 0.001 CD cord-335975-m6lkrehi 3801 28 ) ) -RRB- cord-335975-m6lkrehi 3802 1 ( ( -LRB- cord-335975-m6lkrehi 3802 2 Table table NN cord-335975-m6lkrehi 3802 3 1 1 CD cord-335975-m6lkrehi 3802 4 ) ) -RRB- cord-335975-m6lkrehi 3802 5 . . . cord-335975-m6lkrehi 3803 1 In in IN cord-335975-m6lkrehi 3803 2 clinical clinical JJ cord-335975-m6lkrehi 3803 3 analysis analysis NN cord-335975-m6lkrehi 3803 4 , , , cord-335975-m6lkrehi 3803 5 the the DT cord-335975-m6lkrehi 3803 6 rate rate NN cord-335975-m6lkrehi 3803 7 of of IN cord-335975-m6lkrehi 3803 8 therapeutic therapeutic JJ cord-335975-m6lkrehi 3803 9 failure failure NN cord-335975-m6lkrehi 3803 10 was be VBD cord-335975-m6lkrehi 3803 11 36 36 CD cord-335975-m6lkrehi 3803 12 % % NN cord-335975-m6lkrehi 3803 13 ( ( -LRB- cord-335975-m6lkrehi 3803 14 4 4 CD cord-335975-m6lkrehi 3803 15 11 11 CD cord-335975-m6lkrehi 3803 16 ) ) -RRB- cord-335975-m6lkrehi 3803 17 , , , cord-335975-m6lkrehi 3803 18 with with IN cord-335975-m6lkrehi 3803 19 a a DT cord-335975-m6lkrehi 3803 20 strong strong JJ cord-335975-m6lkrehi 3803 21 association association NN cord-335975-m6lkrehi 3803 22 with with IN cord-335975-m6lkrehi 3803 23 inoculum inoculum NN cord-335975-m6lkrehi 3803 24 effect effect NN cord-335975-m6lkrehi 3803 25 ( ( -LRB- cord-335975-m6lkrehi 3803 26 p p NN cord-335975-m6lkrehi 3803 27 = = SYM cord-335975-m6lkrehi 3803 28 0.02 0.02 CD cord-335975-m6lkrehi 3803 29 ) ) -RRB- cord-335975-m6lkrehi 3803 30 . . . cord-335975-m6lkrehi 3804 1 There there EX cord-335975-m6lkrehi 3804 2 was be VBD cord-335975-m6lkrehi 3804 3 a a DT cord-335975-m6lkrehi 3804 4 strong strong JJ cord-335975-m6lkrehi 3804 5 association association NN cord-335975-m6lkrehi 3804 6 between between IN cord-335975-m6lkrehi 3804 7 therapeutic therapeutic JJ cord-335975-m6lkrehi 3804 8 failure failure NN cord-335975-m6lkrehi 3804 9 , , , cord-335975-m6lkrehi 3804 10 CrCL CrCL NNP cord-335975-m6lkrehi 3804 11 > > XX cord-335975-m6lkrehi 3804 12 200 200 CD cord-335975-m6lkrehi 3804 13 ml ml NN cord-335975-m6lkrehi 3804 14 min min NN cord-335975-m6lkrehi 3804 15 and and CC cord-335975-m6lkrehi 3804 16 PK PK NNP cord-335975-m6lkrehi 3804 17 PD PD NNP cord-335975-m6lkrehi 3804 18 target target NN cord-335975-m6lkrehi 3804 19 non non JJ cord-335975-m6lkrehi 3804 20 - - JJ cord-335975-m6lkrehi 3804 21 attainment attainment JJ cord-335975-m6lkrehi 3804 22 adjusted adjust VBN cord-335975-m6lkrehi 3804 23 on on IN cord-335975-m6lkrehi 3804 24 the the DT cord-335975-m6lkrehi 3804 25 inoculum inoculum NN cord-335975-m6lkrehi 3804 26 effect effect NN cord-335975-m6lkrehi 3804 27 ( ( -LRB- cord-335975-m6lkrehi 3804 28 p p NN cord-335975-m6lkrehi 3804 29 = = SYM cord-335975-m6lkrehi 3804 30 0.04 0.04 CD cord-335975-m6lkrehi 3804 31 ) ) -RRB- cord-335975-m6lkrehi 3804 32 . . . cord-335975-m6lkrehi 3805 1 Introduction introduction NN cord-335975-m6lkrehi 3805 2 : : : cord-335975-m6lkrehi 3806 1 Vancomycin Vancomycin NNP cord-335975-m6lkrehi 3806 2 has have VBZ cord-335975-m6lkrehi 3806 3 long long RB cord-335975-m6lkrehi 3806 4 been be VBN cord-335975-m6lkrehi 3806 5 used use VBN cord-335975-m6lkrehi 3806 6 as as IN cord-335975-m6lkrehi 3806 7 the the DT cord-335975-m6lkrehi 3806 8 standard standard JJ cord-335975-m6lkrehi 3806 9 therapy therapy NN cord-335975-m6lkrehi 3806 10 of of IN cord-335975-m6lkrehi 3806 11 infections infection NNS cord-335975-m6lkrehi 3806 12 due due JJ cord-335975-m6lkrehi 3806 13 to to IN cord-335975-m6lkrehi 3806 14 Methicillin methicillin NN cord-335975-m6lkrehi 3806 15 - - HYPH cord-335975-m6lkrehi 3806 16 resistant resistant JJ cord-335975-m6lkrehi 3806 17 Staphylococcus Staphylococcus NNP cord-335975-m6lkrehi 3806 18 aureus aureus NN cord-335975-m6lkrehi 3806 19 ( ( -LRB- cord-335975-m6lkrehi 3806 20 MRSA MRSA NNP cord-335975-m6lkrehi 3806 21 ) ) -RRB- cord-335975-m6lkrehi 3806 22 . . . cord-335975-m6lkrehi 3807 1 The the DT cord-335975-m6lkrehi 3807 2 side side JJ cord-335975-m6lkrehi 3807 3 effects effect NNS cord-335975-m6lkrehi 3807 4 of of IN cord-335975-m6lkrehi 3807 5 this this DT cord-335975-m6lkrehi 3807 6 drug drug NN cord-335975-m6lkrehi 3807 7 as as RB cord-335975-m6lkrehi 3807 8 well well RB cord-335975-m6lkrehi 3807 9 as as IN cord-335975-m6lkrehi 3807 10 the the DT cord-335975-m6lkrehi 3807 11 increasing increase VBG cord-335975-m6lkrehi 3807 12 resistance resistance NN cord-335975-m6lkrehi 3807 13 and and CC cord-335975-m6lkrehi 3807 14 its -PRON- PRP$ cord-335975-m6lkrehi 3807 15 pharmacodynamics pharmacodynamic NNS cord-335975-m6lkrehi 3807 16 effects effect NNS cord-335975-m6lkrehi 3807 17 have have VBP cord-335975-m6lkrehi 3807 18 fostered foster VBN cord-335975-m6lkrehi 3807 19 the the DT cord-335975-m6lkrehi 3807 20 development development NN cord-335975-m6lkrehi 3807 21 of of IN cord-335975-m6lkrehi 3807 22 newly newly RB cord-335975-m6lkrehi 3807 23 active active JJ cord-335975-m6lkrehi 3807 24 drugs drug NNS cord-335975-m6lkrehi 3807 25 . . . cord-335975-m6lkrehi 3808 1 Nevertheless nevertheless RB cord-335975-m6lkrehi 3808 2 it -PRON- PRP cord-335975-m6lkrehi 3808 3 is be VBZ cord-335975-m6lkrehi 3808 4 still still RB cord-335975-m6lkrehi 3808 5 widely widely RB cord-335975-m6lkrehi 3808 6 prescribed prescribe VBN cord-335975-m6lkrehi 3809 1 and and CC cord-335975-m6lkrehi 3809 2 it -PRON- PRP cord-335975-m6lkrehi 3809 3 stands stand VBZ cord-335975-m6lkrehi 3809 4 as as IN cord-335975-m6lkrehi 3809 5 the the DT cord-335975-m6lkrehi 3809 6 mostly mostly RB cord-335975-m6lkrehi 3809 7 used use VBN cord-335975-m6lkrehi 3809 8 comparator comparator NN cord-335975-m6lkrehi 3809 9 in in IN cord-335975-m6lkrehi 3809 10 randomized randomized JJ cord-335975-m6lkrehi 3809 11 study study NN cord-335975-m6lkrehi 3809 12 . . . cord-335975-m6lkrehi 3810 1 An an DT cord-335975-m6lkrehi 3810 2 assessment assessment NN cord-335975-m6lkrehi 3810 3 of of IN cord-335975-m6lkrehi 3810 4 our -PRON- PRP$ cord-335975-m6lkrehi 3810 5 medical medical JJ cord-335975-m6lkrehi 3810 6 practice practice NN cord-335975-m6lkrehi 3810 7 regarding regard VBG cord-335975-m6lkrehi 3810 8 its -PRON- PRP$ cord-335975-m6lkrehi 3810 9 use use NN cord-335975-m6lkrehi 3810 10 may may MD cord-335975-m6lkrehi 3810 11 enhance enhance VB cord-335975-m6lkrehi 3810 12 compliance compliance NN cord-335975-m6lkrehi 3810 13 to to IN cord-335975-m6lkrehi 3810 14 guidelines guideline NNS cord-335975-m6lkrehi 3810 15 so so IN cord-335975-m6lkrehi 3810 16 as as IN cord-335975-m6lkrehi 3810 17 to to TO cord-335975-m6lkrehi 3810 18 promote promote VB cord-335975-m6lkrehi 3810 19 a a DT cord-335975-m6lkrehi 3810 20 better well JJR cord-335975-m6lkrehi 3810 21 use use NN cord-335975-m6lkrehi 3810 22 of of IN cord-335975-m6lkrehi 3810 23 Vancomycin Vancomycin NNP cord-335975-m6lkrehi 3810 24 . . . cord-335975-m6lkrehi 3811 1 Patients patient NNS cord-335975-m6lkrehi 3811 2 and and CC cord-335975-m6lkrehi 3811 3 methods method NNS cord-335975-m6lkrehi 3811 4 : : : cord-335975-m6lkrehi 3811 5 In in IN cord-335975-m6lkrehi 3811 6 our -PRON- PRP$ cord-335975-m6lkrehi 3811 7 1600 1600 CD cord-335975-m6lkrehi 3811 8 bed bed NN cord-335975-m6lkrehi 3811 9 hospital hospital NN cord-335975-m6lkrehi 3811 10 , , , cord-335975-m6lkrehi 3811 11 the the DT cord-335975-m6lkrehi 3811 12 incidence incidence NN cord-335975-m6lkrehi 3811 13 rate rate NN cord-335975-m6lkrehi 3811 14 of of IN cord-335975-m6lkrehi 3811 15 MRSA MRSA NNP cord-335975-m6lkrehi 3811 16 fell fall VBD cord-335975-m6lkrehi 3811 17 from from IN cord-335975-m6lkrehi 3811 18 0.38 0.38 CD cord-335975-m6lkrehi 3811 19 to to IN cord-335975-m6lkrehi 3811 20 0.24 0.24 CD cord-335975-m6lkrehi 3811 21 per per IN cord-335975-m6lkrehi 3811 22 1000 1000 CD cord-335975-m6lkrehi 3811 23 patient patient JJ cord-335975-m6lkrehi 3811 24 days day NNS cord-335975-m6lkrehi 3811 25 from from IN cord-335975-m6lkrehi 3811 26 2007 2007 CD cord-335975-m6lkrehi 3811 27 to to IN cord-335975-m6lkrehi 3811 28 2012 2012 CD cord-335975-m6lkrehi 3811 29 whereas whereas IN cord-335975-m6lkrehi 3811 30 the the DT cord-335975-m6lkrehi 3811 31 current current JJ cord-335975-m6lkrehi 3811 32 proportion proportion NN cord-335975-m6lkrehi 3811 33 of of IN cord-335975-m6lkrehi 3811 34 MRSA MRSA NNP cord-335975-m6lkrehi 3811 35 isolates isolate NNS cord-335975-m6lkrehi 3811 36 is be VBZ cord-335975-m6lkrehi 3811 37 about about RB cord-335975-m6lkrehi 3811 38 11 11 CD cord-335975-m6lkrehi 3811 39 % % NN cord-335975-m6lkrehi 3811 40 . . . cord-335975-m6lkrehi 3812 1 Vancomycin Vancomycin NNP cord-335975-m6lkrehi 3812 2 is be VBZ cord-335975-m6lkrehi 3812 3 the the DT cord-335975-m6lkrehi 3812 4 most most RBS cord-335975-m6lkrehi 3812 5 prescribed prescribed JJ cord-335975-m6lkrehi 3812 6 empirical empirical JJ cord-335975-m6lkrehi 3812 7 or or CC cord-335975-m6lkrehi 3812 8 targeted target VBN cord-335975-m6lkrehi 3812 9 antibiotic antibiotic JJ cord-335975-m6lkrehi 3812 10 therapy therapy NN cord-335975-m6lkrehi 3812 11 covering cover VBG cord-335975-m6lkrehi 3812 12 MRSA MRSA NNP cord-335975-m6lkrehi 3812 13 in in IN cord-335975-m6lkrehi 3812 14 our -PRON- PRP$ cord-335975-m6lkrehi 3812 15 medical medical JJ cord-335975-m6lkrehi 3812 16 intensive intensive JJ cord-335975-m6lkrehi 3812 17 care care NN cord-335975-m6lkrehi 3812 18 unit unit NN cord-335975-m6lkrehi 3812 19 of of IN cord-335975-m6lkrehi 3812 20 20 20 CD cord-335975-m6lkrehi 3812 21 beds bed NNS cord-335975-m6lkrehi 3812 22 even even RB cord-335975-m6lkrehi 3812 23 if if IN cord-335975-m6lkrehi 3812 24 a a DT cord-335975-m6lkrehi 3812 25 shift shift NN cord-335975-m6lkrehi 3812 26 towards towards IN cord-335975-m6lkrehi 3812 27 the the DT cord-335975-m6lkrehi 3812 28 use use NN cord-335975-m6lkrehi 3812 29 of of IN cord-335975-m6lkrehi 3812 30 linezolid linezolid NNP cord-335975-m6lkrehi 3812 31 in in IN cord-335975-m6lkrehi 3812 32 nosocomial nosocomial JJ cord-335975-m6lkrehi 3812 33 pneumoniae pneumoniae NN cord-335975-m6lkrehi 3812 34 has have VBZ cord-335975-m6lkrehi 3812 35 been be VBN cord-335975-m6lkrehi 3812 36 noticed notice VBN cord-335975-m6lkrehi 3812 37 during during IN cord-335975-m6lkrehi 3812 38 the the DT cord-335975-m6lkrehi 3812 39 last last JJ cord-335975-m6lkrehi 3812 40 3 3 CD cord-335975-m6lkrehi 3812 41 years year NNS cord-335975-m6lkrehi 3812 42 . . . cord-335975-m6lkrehi 3813 1 Key key JJ cord-335975-m6lkrehi 3813 2 points point NNS cord-335975-m6lkrehi 3813 3 regarding regard VBG cord-335975-m6lkrehi 3813 4 the the DT cord-335975-m6lkrehi 3813 5 proper proper JJ cord-335975-m6lkrehi 3813 6 use use NN cord-335975-m6lkrehi 3813 7 of of IN cord-335975-m6lkrehi 3813 8 Vancomycin Vancomycin NNP cord-335975-m6lkrehi 3813 9 have have VBP cord-335975-m6lkrehi 3813 10 been be VBN cord-335975-m6lkrehi 3813 11 implemented implement VBN cord-335975-m6lkrehi 3813 12 in in IN cord-335975-m6lkrehi 3813 13 our -PRON- PRP$ cord-335975-m6lkrehi 3813 14 antibiotic antibiotic JJ cord-335975-m6lkrehi 3813 15 stewardship stewardship NN cord-335975-m6lkrehi 3813 16 program program NN cord-335975-m6lkrehi 3813 17 . . . cord-335975-m6lkrehi 3814 1 Moreover moreover RB cord-335975-m6lkrehi 3814 2 courses course NNS cord-335975-m6lkrehi 3814 3 concerning concern VBG cord-335975-m6lkrehi 3814 4 this this DT cord-335975-m6lkrehi 3814 5 topic topic NN cord-335975-m6lkrehi 3814 6 are be VBP cord-335975-m6lkrehi 3814 7 provided provide VBN cord-335975-m6lkrehi 3814 8 to to IN cord-335975-m6lkrehi 3814 9 our -PRON- PRP$ cord-335975-m6lkrehi 3814 10 junior junior JJ cord-335975-m6lkrehi 3814 11 doctors doctor NNS cord-335975-m6lkrehi 3814 12 . . . cord-335975-m6lkrehi 3815 1 A a DT cord-335975-m6lkrehi 3815 2 retrospective retrospective JJ cord-335975-m6lkrehi 3815 3 review review NN cord-335975-m6lkrehi 3815 4 of of IN cord-335975-m6lkrehi 3815 5 the the DT cord-335975-m6lkrehi 3815 6 quality quality NN cord-335975-m6lkrehi 3815 7 of of IN cord-335975-m6lkrehi 3815 8 antibiotic antibiotic JJ cord-335975-m6lkrehi 3815 9 use use NN cord-335975-m6lkrehi 3815 10 has have VBZ cord-335975-m6lkrehi 3815 11 been be VBN cord-335975-m6lkrehi 3815 12 carried carry VBN cord-335975-m6lkrehi 3815 13 out out RP cord-335975-m6lkrehi 3815 14 in in IN cord-335975-m6lkrehi 3815 15 45 45 CD cord-335975-m6lkrehi 3815 16 courses course NNS cord-335975-m6lkrehi 3815 17 of of IN cord-335975-m6lkrehi 3815 18 Vancomycin Vancomycin NNP cord-335975-m6lkrehi 3815 19 therapy therapy NN cord-335975-m6lkrehi 3815 20 and and CC cord-335975-m6lkrehi 3815 21 the the DT cord-335975-m6lkrehi 3815 22 following follow VBG cord-335975-m6lkrehi 3815 23 criteria criterion NNS cord-335975-m6lkrehi 3815 24 have have VBP cord-335975-m6lkrehi 3815 25 been be VBN cord-335975-m6lkrehi 3815 26 assessed assess VBN cord-335975-m6lkrehi 3815 27 - - HYPH cord-335975-m6lkrehi 3815 28 indication indication NN cord-335975-m6lkrehi 3815 29 , , , cord-335975-m6lkrehi 3815 30 dosing dose VBG cord-335975-m6lkrehi 3815 31 schedules schedule NNS cord-335975-m6lkrehi 3815 32 , , , cord-335975-m6lkrehi 3815 33 serum serum NN cord-335975-m6lkrehi 3815 34 levels level NNS cord-335975-m6lkrehi 3815 35 of of IN cord-335975-m6lkrehi 3815 36 Vancomycin vancomycin NN cord-335975-m6lkrehi 3815 37 , , , cord-335975-m6lkrehi 3815 38 duration duration NN cord-335975-m6lkrehi 3815 39 of of IN cord-335975-m6lkrehi 3815 40 antibiotic antibiotic JJ cord-335975-m6lkrehi 3815 41 therapy therapy NN cord-335975-m6lkrehi 3815 42 and and CC cord-335975-m6lkrehi 3815 43 the the DT cord-335975-m6lkrehi 3815 44 overall overall JJ cord-335975-m6lkrehi 3815 45 degree degree NN cord-335975-m6lkrehi 3815 46 of of IN cord-335975-m6lkrehi 3815 47 conformity conformity NN cord-335975-m6lkrehi 3815 48 of of IN cord-335975-m6lkrehi 3815 49 the the DT cord-335975-m6lkrehi 3815 50 prescription prescription NN cord-335975-m6lkrehi 3815 51 . . . cord-335975-m6lkrehi 3816 1 Results result NNS cord-335975-m6lkrehi 3816 2 : : : cord-335975-m6lkrehi 3817 1 Regarding regard VBG cord-335975-m6lkrehi 3817 2 indication indication NN cord-335975-m6lkrehi 3817 3 , , , cord-335975-m6lkrehi 3817 4 conformity conformity NN cord-335975-m6lkrehi 3817 5 was be VBD cord-335975-m6lkrehi 3817 6 observed observe VBN cord-335975-m6lkrehi 3817 7 in42 in42 NNP cord-335975-m6lkrehi 3817 8 cases case NNS cord-335975-m6lkrehi 3817 9 ( ( -LRB- cord-335975-m6lkrehi 3817 10 93 93 CD cord-335975-m6lkrehi 3817 11 % % NN cord-335975-m6lkrehi 3817 12 ) ) -RRB- cord-335975-m6lkrehi 3817 13 . . . cord-335975-m6lkrehi 3818 1 The the DT cord-335975-m6lkrehi 3818 2 dosing dosing NN cord-335975-m6lkrehi 3818 3 schedule schedule NN cord-335975-m6lkrehi 3818 4 was be VBD cord-335975-m6lkrehi 3818 5 appropriate appropriate JJ cord-335975-m6lkrehi 3818 6 in in IN cord-335975-m6lkrehi 3818 7 32 32 CD cord-335975-m6lkrehi 3818 8 cases case NNS cord-335975-m6lkrehi 3818 9 ( ( -LRB- cord-335975-m6lkrehi 3818 10 71 71 CD cord-335975-m6lkrehi 3818 11 % % NN cord-335975-m6lkrehi 3818 12 ) ) -RRB- cord-335975-m6lkrehi 3818 13 only only RB cord-335975-m6lkrehi 3818 14 . . . cord-335975-m6lkrehi 3819 1 Of of IN cord-335975-m6lkrehi 3819 2 the the DT cord-335975-m6lkrehi 3819 3 remaining remain VBG cord-335975-m6lkrehi 3819 4 13 13 CD cord-335975-m6lkrehi 3819 5 cases case NNS cord-335975-m6lkrehi 3819 6 ( ( -LRB- cord-335975-m6lkrehi 3819 7 29 29 CD cord-335975-m6lkrehi 3819 8 % % NN cord-335975-m6lkrehi 3819 9 ) ) -RRB- cord-335975-m6lkrehi 3819 10 , , , cord-335975-m6lkrehi 3819 11 all all DT cord-335975-m6lkrehi 3819 12 of of IN cord-335975-m6lkrehi 3819 13 them -PRON- PRP cord-335975-m6lkrehi 3819 14 were be VBD cord-335975-m6lkrehi 3819 15 not not RB cord-335975-m6lkrehi 3819 16 adjusted adjust VBN cord-335975-m6lkrehi 3819 17 to to IN cord-335975-m6lkrehi 3819 18 the the DT cord-335975-m6lkrehi 3819 19 serum serum NN cord-335975-m6lkrehi 3819 20 concentration concentration NN cord-335975-m6lkrehi 3819 21 and and CC cord-335975-m6lkrehi 3819 22 in in IN cord-335975-m6lkrehi 3819 23 2 2 CD cord-335975-m6lkrehi 3819 24 cases case NNS cord-335975-m6lkrehi 3819 25 ( ( -LRB- cord-335975-m6lkrehi 3819 26 4 4 CD cord-335975-m6lkrehi 3819 27 % % NN cord-335975-m6lkrehi 3819 28 ) ) -RRB- cord-335975-m6lkrehi 3820 1 the the DT cord-335975-m6lkrehi 3820 2 general general NNP cord-335975-m6lkrehi 3820 3 dosing dosing NN cord-335975-m6lkrehi 3820 4 recommendation recommendation NN cord-335975-m6lkrehi 3820 5 was be VBD cord-335975-m6lkrehi 3820 6 not not RB cord-335975-m6lkrehi 3820 7 respected respect VBN cord-335975-m6lkrehi 3820 8 . . . cord-335975-m6lkrehi 3821 1 The the DT cord-335975-m6lkrehi 3821 2 loading loading NN cord-335975-m6lkrehi 3821 3 dose dose NN cord-335975-m6lkrehi 3821 4 was be VBD cord-335975-m6lkrehi 3821 5 inappropriate inappropriate JJ cord-335975-m6lkrehi 3821 6 in in IN cord-335975-m6lkrehi 3821 7 23 23 CD cord-335975-m6lkrehi 3821 8 cases case NNS cord-335975-m6lkrehi 3821 9 ( ( -LRB- cord-335975-m6lkrehi 3821 10 51 51 CD cord-335975-m6lkrehi 3821 11 % % NN cord-335975-m6lkrehi 3821 12 ) ) -RRB- cord-335975-m6lkrehi 3821 13 and and CC cord-335975-m6lkrehi 3821 14 the the DT cord-335975-m6lkrehi 3821 15 proper proper JJ cord-335975-m6lkrehi 3821 16 follow follow NN cord-335975-m6lkrehi 3821 17 up up IN cord-335975-m6lkrehi 3821 18 of of IN cord-335975-m6lkrehi 3821 19 serum serum NN cord-335975-m6lkrehi 3821 20 levels level NNS cord-335975-m6lkrehi 3821 21 of of IN cord-335975-m6lkrehi 3821 22 vancomycin vancomycin NN cord-335975-m6lkrehi 3821 23 has have VBZ cord-335975-m6lkrehi 3821 24 not not RB cord-335975-m6lkrehi 3821 25 been be VBN cord-335975-m6lkrehi 3821 26 carried carry VBN cord-335975-m6lkrehi 3821 27 out out RP cord-335975-m6lkrehi 3821 28 in in IN cord-335975-m6lkrehi 3821 29 20 20 CD cord-335975-m6lkrehi 3821 30 cases case NNS cord-335975-m6lkrehi 3821 31 ( ( -LRB- cord-335975-m6lkrehi 3821 32 44 44 CD cord-335975-m6lkrehi 3821 33 % % NN cord-335975-m6lkrehi 3821 34 ) ) -RRB- cord-335975-m6lkrehi 3821 35 . . . cord-335975-m6lkrehi 3822 1 The the DT cord-335975-m6lkrehi 3822 2 duration duration NN cord-335975-m6lkrehi 3822 3 of of IN cord-335975-m6lkrehi 3822 4 antibiotic antibiotic JJ cord-335975-m6lkrehi 3822 5 therapy therapy NN cord-335975-m6lkrehi 3822 6 was be VBD cord-335975-m6lkrehi 3822 7 in in IN cord-335975-m6lkrehi 3822 8 compliance compliance NN cord-335975-m6lkrehi 3822 9 with with IN cord-335975-m6lkrehi 3822 10 the the DT cord-335975-m6lkrehi 3822 11 protocol protocol NN cord-335975-m6lkrehi 3822 12 in in IN cord-335975-m6lkrehi 3822 13 42 42 CD cord-335975-m6lkrehi 3822 14 cases case NNS cord-335975-m6lkrehi 3822 15 ( ( -LRB- cord-335975-m6lkrehi 3822 16 93 93 CD cord-335975-m6lkrehi 3822 17 % % NN cord-335975-m6lkrehi 3822 18 ) ) -RRB- cord-335975-m6lkrehi 3822 19 and and CC cord-335975-m6lkrehi 3822 20 a a DT cord-335975-m6lkrehi 3822 21 slight slight JJ cord-335975-m6lkrehi 3822 22 longer long JJR cord-335975-m6lkrehi 3822 23 duration duration NN cord-335975-m6lkrehi 3822 24 was be VBD cord-335975-m6lkrehi 3822 25 observed observe VBN cord-335975-m6lkrehi 3822 26 in in IN cord-335975-m6lkrehi 3822 27 3 3 CD cord-335975-m6lkrehi 3822 28 cases case NNS cord-335975-m6lkrehi 3822 29 ( ( -LRB- cord-335975-m6lkrehi 3822 30 7 7 CD cord-335975-m6lkrehi 3822 31 % % NN cord-335975-m6lkrehi 3822 32 ) ) -RRB- cord-335975-m6lkrehi 3822 33 . . . cord-335975-m6lkrehi 3823 1 Finally finally RB cord-335975-m6lkrehi 3823 2 the the DT cord-335975-m6lkrehi 3823 3 overall overall JJ cord-335975-m6lkrehi 3823 4 degree degree NN cord-335975-m6lkrehi 3823 5 of of IN cord-335975-m6lkrehi 3823 6 conformity conformity NN cord-335975-m6lkrehi 3823 7 of of IN cord-335975-m6lkrehi 3823 8 the the DT cord-335975-m6lkrehi 3823 9 prescription prescription NN cord-335975-m6lkrehi 3823 10 was be VBD cord-335975-m6lkrehi 3823 11 observed observe VBN cord-335975-m6lkrehi 3823 12 in in IN cord-335975-m6lkrehi 3823 13 7 7 CD cord-335975-m6lkrehi 3823 14 cases case NNS cord-335975-m6lkrehi 3823 15 ( ( -LRB- cord-335975-m6lkrehi 3823 16 16 16 CD cord-335975-m6lkrehi 3823 17 % % NN cord-335975-m6lkrehi 3823 18 ) ) -RRB- cord-335975-m6lkrehi 3823 19 only only RB cord-335975-m6lkrehi 3823 20 . . . cord-335975-m6lkrehi 3824 1 Table table NN cord-335975-m6lkrehi 3824 2 1 1 CD cord-335975-m6lkrehi 3824 3 . . . cord-335975-m6lkrehi 3825 1 In in IN cord-335975-m6lkrehi 3825 2 the the DT cord-335975-m6lkrehi 3825 3 SFAR SFAR NNP cord-335975-m6lkrehi 3825 4 SRLF SRLF NNP cord-335975-m6lkrehi 3825 5 guideline guideline NN cord-335975-m6lkrehi 3825 6 , , , cord-335975-m6lkrehi 3825 7 the the DT cord-335975-m6lkrehi 3825 8 limitation limitation NN cord-335975-m6lkrehi 3825 9 of of IN cord-335975-m6lkrehi 3825 10 the the DT cord-335975-m6lkrehi 3825 11 echinocandins echinocandin NNS cord-335975-m6lkrehi 3825 12 use use NN cord-335975-m6lkrehi 3825 13 to to IN cord-335975-m6lkrehi 3825 14 the the DT cord-335975-m6lkrehi 3825 15 benefit benefit NN cord-335975-m6lkrehi 3825 16 of of IN cord-335975-m6lkrehi 3825 17 ampho ampho NNP cord-335975-m6lkrehi 3825 18 deoxycholate deoxycholate NNP cord-335975-m6lkrehi 3825 19 explains explain VBZ cord-335975-m6lkrehi 3825 20 most most JJS cord-335975-m6lkrehi 3825 21 of of IN cord-335975-m6lkrehi 3825 22 the the DT cord-335975-m6lkrehi 3825 23 poor poor JJ cord-335975-m6lkrehi 3825 24 agreement agreement NN cord-335975-m6lkrehi 3825 25 or or CC cord-335975-m6lkrehi 3825 26 consensus consensus NN cord-335975-m6lkrehi 3825 27 rate rate NN cord-335975-m6lkrehi 3825 28 between between IN cord-335975-m6lkrehi 3825 29 investigators investigator NNS cord-335975-m6lkrehi 3825 30 . . . cord-335975-m6lkrehi 3826 1 The the DT cord-335975-m6lkrehi 3826 2 IDSA IDSA NNP cord-335975-m6lkrehi 3826 3 ESCMID ESCMID NNP cord-335975-m6lkrehi 3826 4 guideline guideline NN cord-335975-m6lkrehi 3826 5 are be VBP cord-335975-m6lkrehi 3826 6 more more RBR cord-335975-m6lkrehi 3826 7 helpful helpful JJ cord-335975-m6lkrehi 3826 8 to to TO cord-335975-m6lkrehi 3826 9 guide guide VB cord-335975-m6lkrehi 3826 10 indications indication NNS cord-335975-m6lkrehi 3826 11 of of IN cord-335975-m6lkrehi 3826 12 empirical empirical JJ cord-335975-m6lkrehi 3826 13 treatment treatment NN cord-335975-m6lkrehi 3826 14 which which WDT cord-335975-m6lkrehi 3826 15 mainly mainly RB cord-335975-m6lkrehi 3826 16 explains explain VBZ cord-335975-m6lkrehi 3826 17 their -PRON- PRP$ cord-335975-m6lkrehi 3826 18 higher high JJR cord-335975-m6lkrehi 3826 19 rate rate NN cord-335975-m6lkrehi 3826 20 of of IN cord-335975-m6lkrehi 3826 21 both both CC cord-335975-m6lkrehi 3826 22 applicability applicability NN cord-335975-m6lkrehi 3826 23 and and CC cord-335975-m6lkrehi 3826 24 agreement agreement NN cord-335975-m6lkrehi 3826 25 rate rate NN cord-335975-m6lkrehi 3826 26 . . . cord-335975-m6lkrehi 3827 1 The the DT cord-335975-m6lkrehi 3827 2 rates rate NNS cord-335975-m6lkrehi 3827 3 of of IN cord-335975-m6lkrehi 3827 4 agreement agreement NN cord-335975-m6lkrehi 3827 5 do do VBP cord-335975-m6lkrehi 3827 6 not not RB cord-335975-m6lkrehi 3827 7 reflect reflect VB cord-335975-m6lkrehi 3827 8 whether whether IN cord-335975-m6lkrehi 3827 9 the the DT cord-335975-m6lkrehi 3827 10 choice choice NN cord-335975-m6lkrehi 3827 11 between between IN cord-335975-m6lkrehi 3827 12 different different JJ cord-335975-m6lkrehi 3827 13 class class NN cord-335975-m6lkrehi 3827 14 III iii CD cord-335975-m6lkrehi 3827 15 antifungal antifungal JJ cord-335975-m6lkrehi 3827 16 therapies therapy NNS cord-335975-m6lkrehi 3827 17 is be VBZ cord-335975-m6lkrehi 3827 18 the the DT cord-335975-m6lkrehi 3827 19 best good JJS cord-335975-m6lkrehi 3827 20 or or CC cord-335975-m6lkrehi 3827 21 not not RB cord-335975-m6lkrehi 3827 22 . . . cord-335975-m6lkrehi 3828 1 Conclusion conclusion NN cord-335975-m6lkrehi 3828 2 : : : cord-335975-m6lkrehi 3829 1 The the DT cord-335975-m6lkrehi 3829 2 IDSA IDSA NNP cord-335975-m6lkrehi 3829 3 guideline guideline NN cord-335975-m6lkrehi 3829 4 seems seem VBZ cord-335975-m6lkrehi 3829 5 to to TO cord-335975-m6lkrehi 3829 6 take take VB cord-335975-m6lkrehi 3829 7 a a DT cord-335975-m6lkrehi 3829 8 broader broad JJR cord-335975-m6lkrehi 3829 9 spectrum spectrum NN cord-335975-m6lkrehi 3829 10 of of IN cord-335975-m6lkrehi 3829 11 clinical clinical JJ cord-335975-m6lkrehi 3829 12 situations situation NNS cord-335975-m6lkrehi 3829 13 into into IN cord-335975-m6lkrehi 3829 14 account account NN cord-335975-m6lkrehi 3829 15 , , , cord-335975-m6lkrehi 3829 16 particularly particularly RB cord-335975-m6lkrehi 3829 17 in in IN cord-335975-m6lkrehi 3829 18 guiding guide VBG cord-335975-m6lkrehi 3829 19 more more RBR cord-335975-m6lkrehi 3829 20 precisely precisely RB cord-335975-m6lkrehi 3829 21 indications indication NNS cord-335975-m6lkrehi 3829 22 of of IN cord-335975-m6lkrehi 3829 23 empirical empirical JJ cord-335975-m6lkrehi 3829 24 treatments treatment NNS cord-335975-m6lkrehi 3829 25 . . . cord-335975-m6lkrehi 3830 1 ESCMID ESCMID NNP cord-335975-m6lkrehi 3830 2 or or CC cord-335975-m6lkrehi 3830 3 IDSA IDSA NNP cord-335975-m6lkrehi 3830 4 reach reach VBP cord-335975-m6lkrehi 3830 5 more more RBR cord-335975-m6lkrehi 3830 6 often often RB cord-335975-m6lkrehi 3830 7 consensus consensus NN cord-335975-m6lkrehi 3830 8 at at IN cord-335975-m6lkrehi 3830 9 the the DT cord-335975-m6lkrehi 3830 10 first first JJ cord-335975-m6lkrehi 3830 11 reading reading NN cord-335975-m6lkrehi 3830 12 . . . cord-335975-m6lkrehi 3831 1 ( ( -LRB- cord-335975-m6lkrehi 3831 2 6 6 CD cord-335975-m6lkrehi 3831 3 19 19 CD cord-335975-m6lkrehi 3831 4 ) ) -RRB- cord-335975-m6lkrehi 3831 5 , , , cord-335975-m6lkrehi 3831 6 and and CC cord-335975-m6lkrehi 3831 7 was be VBD cord-335975-m6lkrehi 3831 8 discovered discover VBN cord-335975-m6lkrehi 3831 9 during during IN cord-335975-m6lkrehi 3831 10 a a DT cord-335975-m6lkrehi 3831 11 chest chest NN cord-335975-m6lkrehi 3831 12 X x NN cord-335975-m6lkrehi 3831 13 - - NN cord-335975-m6lkrehi 3831 14 ray ray JJ cord-335975-m6lkrehi 3831 15 examination examination NN cord-335975-m6lkrehi 3831 16 for for IN cord-335975-m6lkrehi 3831 17 68 68 CD cord-335975-m6lkrehi 3831 18 % % NN cord-335975-m6lkrehi 3831 19 ( ( -LRB- cord-335975-m6lkrehi 3831 20 13 13 CD cord-335975-m6lkrehi 3831 21 19 19 CD cord-335975-m6lkrehi 3831 22 ) ) -RRB- cord-335975-m6lkrehi 3831 23 . . . cord-335975-m6lkrehi 3832 1 Diaphragmatic diaphragmatic JJ cord-335975-m6lkrehi 3832 2 paralysis paralysis NN cord-335975-m6lkrehi 3832 3 was be VBD cord-335975-m6lkrehi 3832 4 confirmed confirm VBN cord-335975-m6lkrehi 3832 5 for for IN cord-335975-m6lkrehi 3832 6 all all DT cord-335975-m6lkrehi 3832 7 cases case NNS cord-335975-m6lkrehi 3832 8 with with IN cord-335975-m6lkrehi 3832 9 chest chest NN cord-335975-m6lkrehi 3832 10 ultrasound.39 ultrasound.39 NNP cord-335975-m6lkrehi 3832 11 % % NN cord-335975-m6lkrehi 3832 12 of of IN cord-335975-m6lkrehi 3832 13 patients patient NNS cord-335975-m6lkrehi 3832 14 ( ( -LRB- cord-335975-m6lkrehi 3832 15 7 7 CD cord-335975-m6lkrehi 3832 16 18 18 CD cord-335975-m6lkrehi 3832 17 ) ) -RRB- cord-335975-m6lkrehi 3832 18 were be VBD cord-335975-m6lkrehi 3832 19 receiving receive VBG cord-335975-m6lkrehi 3832 20 mechanical mechanical JJ cord-335975-m6lkrehi 3832 21 ventilation ventilation NN cord-335975-m6lkrehi 3832 22 at at IN cord-335975-m6lkrehi 3832 23 the the DT cord-335975-m6lkrehi 3832 24 moment moment NN cord-335975-m6lkrehi 3832 25 of of IN cord-335975-m6lkrehi 3832 26 the the DT cord-335975-m6lkrehi 3832 27 diagnosis diagnosis NN cord-335975-m6lkrehi 3832 28 . . . cord-335975-m6lkrehi 3833 1 The the DT cord-335975-m6lkrehi 3833 2 paralysed paralysed JJ cord-335975-m6lkrehi 3833 3 hemidiaphragm hemidiaphragm NN cord-335975-m6lkrehi 3833 4 was be VBD cord-335975-m6lkrehi 3833 5 left leave VBN cord-335975-m6lkrehi 3833 6 sided sided JJ cord-335975-m6lkrehi 3833 7 in in IN cord-335975-m6lkrehi 3833 8 52 52 CD cord-335975-m6lkrehi 3833 9 % % NN cord-335975-m6lkrehi 3833 10 ( ( -LRB- cord-335975-m6lkrehi 3833 11 10 10 CD cord-335975-m6lkrehi 3833 12 19 19 CD cord-335975-m6lkrehi 3833 13 ) ) -RRB- cord-335975-m6lkrehi 3833 14 , , , cord-335975-m6lkrehi 3833 15 and and CC cord-335975-m6lkrehi 3833 16 right right RB cord-335975-m6lkrehi 3833 17 sided side VBD cord-335975-m6lkrehi 3833 18 in in IN cord-335975-m6lkrehi 3833 19 48 48 CD cord-335975-m6lkrehi 3833 20 % % NN cord-335975-m6lkrehi 3833 21 ( ( -LRB- cord-335975-m6lkrehi 3833 22 9 9 CD cord-335975-m6lkrehi 3833 23 19 19 CD cord-335975-m6lkrehi 3833 24 ) ) -RRB- cord-335975-m6lkrehi 3833 25 . . . cord-335975-m6lkrehi 3834 1 There there EX cord-335975-m6lkrehi 3834 2 was be VBD cord-335975-m6lkrehi 3834 3 no no DT cord-335975-m6lkrehi 3834 4 bilateral bilateral JJ cord-335975-m6lkrehi 3834 5 diaphragmatic diaphragmatic JJ cord-335975-m6lkrehi 3834 6 paralysis paralysis NN cord-335975-m6lkrehi 3834 7 . . . cord-335975-m6lkrehi 3835 1 Hemi Hemi NNP cord-335975-m6lkrehi 3835 2 - - HYPH cord-335975-m6lkrehi 3835 3 diaphragmatic diaphragmatic JJ cord-335975-m6lkrehi 3835 4 plication plication NN cord-335975-m6lkrehi 3835 5 was be VBD cord-335975-m6lkrehi 3835 6 performed perform VBN cord-335975-m6lkrehi 3835 7 in in IN cord-335975-m6lkrehi 3835 8 30 30 CD cord-335975-m6lkrehi 3835 9 % % NN cord-335975-m6lkrehi 3835 10 of of IN cord-335975-m6lkrehi 3835 11 the the DT cord-335975-m6lkrehi 3835 12 patients patient NNS cord-335975-m6lkrehi 3835 13 ( ( -LRB- cord-335975-m6lkrehi 3835 14 6 6 CD cord-335975-m6lkrehi 3835 15 20 20 CD cord-335975-m6lkrehi 3835 16 ) ) -RRB- cord-335975-m6lkrehi 3835 17 , , , cord-335975-m6lkrehi 3835 18 and and CC cord-335975-m6lkrehi 3835 19 median median JJ cord-335975-m6lkrehi 3835 20 time time NN cord-335975-m6lkrehi 3835 21 from from IN cord-335975-m6lkrehi 3835 22 cardiac cardiac JJ cord-335975-m6lkrehi 3835 23 surgery surgery NN cord-335975-m6lkrehi 3835 24 to to IN cord-335975-m6lkrehi 3835 25 surgical surgical JJ cord-335975-m6lkrehi 3835 26 plication plication NN cord-335975-m6lkrehi 3835 27 was be VBD cord-335975-m6lkrehi 3835 28 21 21 CD cord-335975-m6lkrehi 3835 29 days day NNS cord-335975-m6lkrehi 3835 30 ( ( -LRB- cord-335975-m6lkrehi 3835 31 range range NNP cord-335975-m6lkrehi 3835 32 8 8 CD cord-335975-m6lkrehi 3835 33 - - SYM cord-335975-m6lkrehi 3835 34 38 38 CD cord-335975-m6lkrehi 3835 35 days day NNS cord-335975-m6lkrehi 3835 36 ) ) -RRB- cord-335975-m6lkrehi 3835 37 . . . cord-335975-m6lkrehi 3836 1 Indications indication NNS cord-335975-m6lkrehi 3836 2 for for IN cord-335975-m6lkrehi 3836 3 plication plication NN cord-335975-m6lkrehi 3836 4 were be VBD cord-335975-m6lkrehi 3836 5 failure failure NN cord-335975-m6lkrehi 3836 6 to to TO cord-335975-m6lkrehi 3836 7 wean wean VB cord-335975-m6lkrehi 3836 8 from from IN cord-335975-m6lkrehi 3836 9 ventilator ventilator NN cord-335975-m6lkrehi 3836 10 ( ( -LRB- cord-335975-m6lkrehi 3836 11 100 100 CD cord-335975-m6lkrehi 3836 12 % % NN cord-335975-m6lkrehi 3836 13 , , , cord-335975-m6lkrehi 3836 14 6 6 CD cord-335975-m6lkrehi 3836 15 6 6 CD cord-335975-m6lkrehi 3836 16 ) ) -RRB- cord-335975-m6lkrehi 3836 17 , , , cord-335975-m6lkrehi 3836 18 and and CC cord-335975-m6lkrehi 3836 19 respiratory respiratory JJ cord-335975-m6lkrehi 3836 20 distress distress NN cord-335975-m6lkrehi 3836 21 ( ( -LRB- cord-335975-m6lkrehi 3836 22 33 33 CD cord-335975-m6lkrehi 3836 23 % % NN cord-335975-m6lkrehi 3836 24 , , , cord-335975-m6lkrehi 3836 25 2 2 CD cord-335975-m6lkrehi 3836 26 6 6 CD cord-335975-m6lkrehi 3836 27 ) ) -RRB- cord-335975-m6lkrehi 3836 28 . . . cord-335975-m6lkrehi 3837 1 Plicatured plicatured JJ cord-335975-m6lkrehi 3837 2 patients patient NNS cord-335975-m6lkrehi 3837 3 were be VBD cord-335975-m6lkrehi 3837 4 remarkably remarkably RB cord-335975-m6lkrehi 3837 5 younger young JJR cord-335975-m6lkrehi 3837 6 ( ( -LRB- cord-335975-m6lkrehi 3837 7 median median JJ cord-335975-m6lkrehi 3837 8 age age NN cord-335975-m6lkrehi 3837 9 at at IN cord-335975-m6lkrehi 3837 10 cardiac cardiac JJ cord-335975-m6lkrehi 3837 11 surgery-23 surgery-23 CD cord-335975-m6lkrehi 3837 12 days day NNS cord-335975-m6lkrehi 3837 13 , , , cord-335975-m6lkrehi 3838 1 range range NNP cord-335975-m6lkrehi 3838 2 4 4 CD cord-335975-m6lkrehi 3838 3 - - SYM cord-335975-m6lkrehi 3838 4 82 82 CD cord-335975-m6lkrehi 3838 5 days day NNS cord-335975-m6lkrehi 3838 6 ) ) -RRB- cord-335975-m6lkrehi 3838 7 than than IN cord-335975-m6lkrehi 3838 8 non non JJ cord-335975-m6lkrehi 3838 9 - - JJ cord-335975-m6lkrehi 3838 10 plicatured plicatured JJ cord-335975-m6lkrehi 3838 11 patients patient NNS cord-335975-m6lkrehi 3838 12 ( ( -LRB- cord-335975-m6lkrehi 3838 13 7.7 7.7 CD cord-335975-m6lkrehi 3838 14 months month NNS cord-335975-m6lkrehi 3838 15 , , , cord-335975-m6lkrehi 3838 16 range range VBP cord-335975-m6lkrehi 3838 17 5 5 CD cord-335975-m6lkrehi 3838 18 days-5 days-5 NNP cord-335975-m6lkrehi 3838 19 years year NNS cord-335975-m6lkrehi 3838 20 ) ) -RRB- cord-335975-m6lkrehi 3838 21 . . . cord-335975-m6lkrehi 3839 1 The the DT cord-335975-m6lkrehi 3839 2 median median JJ cord-335975-m6lkrehi 3839 3 ventilation ventilation NN cord-335975-m6lkrehi 3839 4 time time NN cord-335975-m6lkrehi 3839 5 after after IN cord-335975-m6lkrehi 3839 6 plication plication NN cord-335975-m6lkrehi 3839 7 was be VBD cord-335975-m6lkrehi 3839 8 3 3 CD cord-335975-m6lkrehi 3839 9 days day NNS cord-335975-m6lkrehi 3839 10 ( ( -LRB- cord-335975-m6lkrehi 3839 11 range range NNP cord-335975-m6lkrehi 3839 12 2 2 CD cord-335975-m6lkrehi 3839 13 - - SYM cord-335975-m6lkrehi 3839 14 6 6 CD cord-335975-m6lkrehi 3839 15 days day NNS cord-335975-m6lkrehi 3839 16 ) ) -RRB- cord-335975-m6lkrehi 3839 17 . . . cord-335975-m6lkrehi 3840 1 All all DT cord-335975-m6lkrehi 3840 2 patients patient NNS cord-335975-m6lkrehi 3840 3 were be VBD cord-335975-m6lkrehi 3840 4 asymptomatic asymptomatic JJ cord-335975-m6lkrehi 3840 5 after after IN cord-335975-m6lkrehi 3840 6 diaphragmatic diaphragmatic JJ cord-335975-m6lkrehi 3840 7 plication plication NN cord-335975-m6lkrehi 3840 8 . . . cord-335975-m6lkrehi 3841 1 Two two CD cord-335975-m6lkrehi 3841 2 patients patient NNS cord-335975-m6lkrehi 3841 3 died die VBD cord-335975-m6lkrehi 3841 4 ( ( -LRB- cord-335975-m6lkrehi 3841 5 10 10 CD cord-335975-m6lkrehi 3841 6 % % NN cord-335975-m6lkrehi 3841 7 ) ) -RRB- cord-335975-m6lkrehi 3841 8 . . . cord-335975-m6lkrehi 3842 1 Cause cause NN cord-335975-m6lkrehi 3842 2 of of IN cord-335975-m6lkrehi 3842 3 death death NN cord-335975-m6lkrehi 3842 4 was be VBD cord-335975-m6lkrehi 3842 5 independant independant JJ cord-335975-m6lkrehi 3842 6 from from IN cord-335975-m6lkrehi 3842 7 surgical surgical JJ cord-335975-m6lkrehi 3842 8 plication plication NN cord-335975-m6lkrehi 3843 1 ( ( -LRB- cord-335975-m6lkrehi 3843 2 cardiogenic cardiogenic JJ cord-335975-m6lkrehi 3843 3 shock shock NN cord-335975-m6lkrehi 3843 4 , , , cord-335975-m6lkrehi 3843 5 septic septic JJ cord-335975-m6lkrehi 3843 6 shock shock NN cord-335975-m6lkrehi 3843 7 ) ) -RRB- cord-335975-m6lkrehi 3843 8 . . . cord-335975-m6lkrehi 3844 1 Conclusion conclusion NN cord-335975-m6lkrehi 3844 2 : : : cord-335975-m6lkrehi 3844 3 Diaphragmatic diaphragmatic JJ cord-335975-m6lkrehi 3844 4 paralysis paralysis NN cord-335975-m6lkrehi 3844 5 is be VBZ cord-335975-m6lkrehi 3844 6 a a DT cord-335975-m6lkrehi 3844 7 rare rare JJ cord-335975-m6lkrehi 3844 8 but but CC cord-335975-m6lkrehi 3844 9 serious serious JJ cord-335975-m6lkrehi 3844 10 complication complication NN cord-335975-m6lkrehi 3844 11 of of IN cord-335975-m6lkrehi 3844 12 cardiac cardiac JJ cord-335975-m6lkrehi 3844 13 surgery surgery NN cord-335975-m6lkrehi 3844 14 in in IN cord-335975-m6lkrehi 3844 15 children child NNS cord-335975-m6lkrehi 3844 16 . . . cord-335975-m6lkrehi 3845 1 It -PRON- PRP cord-335975-m6lkrehi 3845 2 commonly commonly RB cord-335975-m6lkrehi 3845 3 occurs occur VBZ cord-335975-m6lkrehi 3845 4 after after IN cord-335975-m6lkrehi 3845 5 open open JJ cord-335975-m6lkrehi 3845 6 - - HYPH cord-335975-m6lkrehi 3845 7 heart heart NN cord-335975-m6lkrehi 3845 8 surgery surgery NN cord-335975-m6lkrehi 3845 9 , , , cord-335975-m6lkrehi 3845 10 and and CC cord-335975-m6lkrehi 3845 11 specifically specifically RB cord-335975-m6lkrehi 3845 12 after after IN cord-335975-m6lkrehi 3845 13 arterial arterial JJ cord-335975-m6lkrehi 3845 14 switch switch NN cord-335975-m6lkrehi 3845 15 operation operation NN cord-335975-m6lkrehi 3845 16 . . . cord-335975-m6lkrehi 3846 1 Plicatured plicatured JJ cord-335975-m6lkrehi 3846 2 patients patient NNS cord-335975-m6lkrehi 3846 3 were be VBD cord-335975-m6lkrehi 3846 4 younger young JJR cord-335975-m6lkrehi 3846 5 than than IN cord-335975-m6lkrehi 3846 6 non non JJ cord-335975-m6lkrehi 3846 7 - - JJ cord-335975-m6lkrehi 3846 8 plicatured plicatured JJ cord-335975-m6lkrehi 3846 9 patients patient NNS cord-335975-m6lkrehi 3846 10 and and CC cord-335975-m6lkrehi 3846 11 needed need VBD cord-335975-m6lkrehi 3846 12 more more RBR cord-335975-m6lkrehi 3846 13 frequently frequently RB cord-335975-m6lkrehi 3846 14 a a DT cord-335975-m6lkrehi 3846 15 ventilatory ventilatory JJ cord-335975-m6lkrehi 3846 16 support support NN cord-335975-m6lkrehi 3846 17 . . . cord-335975-m6lkrehi 3847 1 A a DT cord-335975-m6lkrehi 3847 2 closer close JJR cord-335975-m6lkrehi 3847 3 monitoring monitoring NN cord-335975-m6lkrehi 3847 4 may may MD cord-335975-m6lkrehi 3847 5 be be VB cord-335975-m6lkrehi 3847 6 required require VBN cord-335975-m6lkrehi 3847 7 for for IN cord-335975-m6lkrehi 3847 8 young young JJ cord-335975-m6lkrehi 3847 9 patients patient NNS cord-335975-m6lkrehi 3847 10 and and CC cord-335975-m6lkrehi 3847 11 mechanically mechanically RB cord-335975-m6lkrehi 3847 12 ventilated ventilate VBD cord-335975-m6lkrehi 3847 13 patients patient NNS cord-335975-m6lkrehi 3847 14 . . . cord-335975-m6lkrehi 3848 1 Indeed indeed RB cord-335975-m6lkrehi 3848 2 , , , cord-335975-m6lkrehi 3848 3 both both DT cord-335975-m6lkrehi 3848 4 are be VBP cord-335975-m6lkrehi 3848 5 more more RBR cord-335975-m6lkrehi 3848 6 likely likely JJ cord-335975-m6lkrehi 3848 7 to to TO cord-335975-m6lkrehi 3848 8 be be VB cord-335975-m6lkrehi 3848 9 treated treat VBN cord-335975-m6lkrehi 3848 10 by by IN cord-335975-m6lkrehi 3848 11 a a DT cord-335975-m6lkrehi 3848 12 diaphragmatic diaphragmatic JJ cord-335975-m6lkrehi 3848 13 plication plication NN cord-335975-m6lkrehi 3848 14 , , , cord-335975-m6lkrehi 3848 15 reducing reduce VBG cord-335975-m6lkrehi 3848 16 mechanical mechanical JJ cord-335975-m6lkrehi 3848 17 ventilation ventilation NN cord-335975-m6lkrehi 3848 18 and and CC cord-335975-m6lkrehi 3848 19 intensive intensive JJ cord-335975-m6lkrehi 3848 20 care care NN cord-335975-m6lkrehi 3848 21 duration duration NN cord-335975-m6lkrehi 3848 22 . . . cord-335975-m6lkrehi 3848 23 _SP cord-335975-m6lkrehi 3849 1 A a DT cord-335975-m6lkrehi 3849 2 prospective prospective JJ cord-335975-m6lkrehi 3849 3 study study NN cord-335975-m6lkrehi 3849 4 . . . cord-335975-m6lkrehi 3850 1 Consecutive consecutive JJ cord-335975-m6lkrehi 3850 2 children child NNS cord-335975-m6lkrehi 3850 3 aged age VBN cord-335975-m6lkrehi 3850 4 between between IN cord-335975-m6lkrehi 3850 5 7 7 CD cord-335975-m6lkrehi 3850 6 days day NNS cord-335975-m6lkrehi 3850 7 and and CC cord-335975-m6lkrehi 3850 8 18-year 18-year JJ cord-335975-m6lkrehi 3850 9 - - HYPH cord-335975-m6lkrehi 3850 10 old old JJ cord-335975-m6lkrehi 3850 11 admitted admit VBD cord-335975-m6lkrehi 3850 12 to to IN cord-335975-m6lkrehi 3850 13 the the DT cord-335975-m6lkrehi 3850 14 PICU PICU NNP cord-335975-m6lkrehi 3850 15 , , , cord-335975-m6lkrehi 3850 16 intubated intubate VBN cord-335975-m6lkrehi 3850 17 and and CC cord-335975-m6lkrehi 3850 18 mechanically mechanically RB cord-335975-m6lkrehi 3850 19 ventilated ventilate VBN cord-335975-m6lkrehi 3850 20 were be VBD cord-335975-m6lkrehi 3850 21 eligible eligible JJ cord-335975-m6lkrehi 3850 22 and and CC cord-335975-m6lkrehi 3850 23 they -PRON- PRP cord-335975-m6lkrehi 3850 24 reached reach VBD cord-335975-m6lkrehi 3850 25 inclusion inclusion NN cord-335975-m6lkrehi 3850 26 if if IN cord-335975-m6lkrehi 3850 27 they -PRON- PRP cord-335975-m6lkrehi 3850 28 had have VBD cord-335975-m6lkrehi 3850 29 at at RB cord-335975-m6lkrehi 3850 30 least least RBS cord-335975-m6lkrehi 3850 31 one one CD cord-335975-m6lkrehi 3850 32 chest chest NN cord-335975-m6lkrehi 3850 33 tube tube NN cord-335975-m6lkrehi 3850 34 . . . cord-335975-m6lkrehi 3851 1 PPL PPL NNP cord-335975-m6lkrehi 3851 2 was be VBD cord-335975-m6lkrehi 3851 3 directly directly RB cord-335975-m6lkrehi 3851 4 measured measure VBN cord-335975-m6lkrehi 3851 5 by by IN cord-335975-m6lkrehi 3851 6 a a DT cord-335975-m6lkrehi 3851 7 pressure pressure NN cord-335975-m6lkrehi 3851 8 transducer transducer NN cord-335975-m6lkrehi 3851 9 connected connect VBN cord-335975-m6lkrehi 3851 10 through through IN cord-335975-m6lkrehi 3851 11 a a DT cord-335975-m6lkrehi 3851 12 needle needle NN cord-335975-m6lkrehi 3851 13 inserted insert VBN cord-335975-m6lkrehi 3851 14 into into IN cord-335975-m6lkrehi 3851 15 the the DT cord-335975-m6lkrehi 3851 16 existing exist VBG cord-335975-m6lkrehi 3851 17 chest chest NN cord-335975-m6lkrehi 3851 18 tube tube NN cord-335975-m6lkrehi 3851 19 . . . cord-335975-m6lkrehi 3852 1 PES PES NNP cord-335975-m6lkrehi 3852 2 was be VBD cord-335975-m6lkrehi 3852 3 measured measure VBN cord-335975-m6lkrehi 3852 4 by by IN cord-335975-m6lkrehi 3852 5 both both CC cord-335975-m6lkrehi 3852 6 a a DT cord-335975-m6lkrehi 3852 7 specific specific JJ cord-335975-m6lkrehi 3852 8 probe probe NN cord-335975-m6lkrehi 3852 9 ( ( -LRB- cord-335975-m6lkrehi 3852 10 Gaeltec Gaeltec NNP cord-335975-m6lkrehi 3852 11 probe probe NN cord-335975-m6lkrehi 3852 12 ) ) -RRB- cord-335975-m6lkrehi 3852 13 and and CC cord-335975-m6lkrehi 3852 14 by by IN cord-335975-m6lkrehi 3852 15 the the DT cord-335975-m6lkrehi 3852 16 feeding feeding NN cord-335975-m6lkrehi 3852 17 tube tube NN cord-335975-m6lkrehi 3852 18 after after IN cord-335975-m6lkrehi 3852 19 mobilization mobilization NN cord-335975-m6lkrehi 3852 20 ( ( -LRB- cord-335975-m6lkrehi 3852 21 PES PES NNP cord-335975-m6lkrehi 3852 22 - - HYPH cord-335975-m6lkrehi 3852 23 FT FT NNP cord-335975-m6lkrehi 3852 24 ) ) -RRB- cord-335975-m6lkrehi 3852 25 . . . cord-335975-m6lkrehi 3853 1 Results result NNS cord-335975-m6lkrehi 3853 2 : : : cord-335975-m6lkrehi 3853 3 12 12 CD cord-335975-m6lkrehi 3853 4 patients patient NNS cord-335975-m6lkrehi 3853 5 ( ( -LRB- cord-335975-m6lkrehi 3853 6 median median JJ cord-335975-m6lkrehi 3853 7 age age NN cord-335975-m6lkrehi 3853 8 3 3 CD cord-335975-m6lkrehi 3853 9 months month NNS cord-335975-m6lkrehi 3853 10 ( ( -LRB- cord-335975-m6lkrehi 3853 11 interquartile interquartile JJ cord-335975-m6lkrehi 3853 12 + + SYM cord-335975-m6lkrehi 3853 13 1 1 CD cord-335975-m6lkrehi 3853 14 - - SYM cord-335975-m6lkrehi 3853 15 4 4 CD cord-335975-m6lkrehi 3853 16 ) ) -RRB- cord-335975-m6lkrehi 3853 17 ) ) -RRB- cord-335975-m6lkrehi 3853 18 were be VBD cord-335975-m6lkrehi 3853 19 included include VBN cord-335975-m6lkrehi 3853 20 and and CC cord-335975-m6lkrehi 3853 21 exploitable exploitable JJ cord-335975-m6lkrehi 3853 22 signals signal NNS cord-335975-m6lkrehi 3853 23 were be VBD cord-335975-m6lkrehi 3853 24 finally finally RB cord-335975-m6lkrehi 3853 25 available available JJ cord-335975-m6lkrehi 3853 26 in in IN cord-335975-m6lkrehi 3853 27 9 9 CD cord-335975-m6lkrehi 3853 28 patients patient NNS cord-335975-m6lkrehi 3853 29 , , , cord-335975-m6lkrehi 3853 30 who who WP cord-335975-m6lkrehi 3853 31 were be VBD cord-335975-m6lkrehi 3853 32 included include VBN cord-335975-m6lkrehi 3853 33 in in IN cord-335975-m6lkrehi 3853 34 the the DT cord-335975-m6lkrehi 3853 35 analysis analysis NN cord-335975-m6lkrehi 3853 36 . . . cord-335975-m6lkrehi 3854 1 Most Most JJS cord-335975-m6lkrehi 3854 2 of of IN cord-335975-m6lkrehi 3854 3 patients patient NNS cord-335975-m6lkrehi 3854 4 ( ( -LRB- cord-335975-m6lkrehi 3854 5 n n NN cord-335975-m6lkrehi 3854 6 = = SYM cord-335975-m6lkrehi 3854 7 11 11 CD cord-335975-m6lkrehi 3854 8 ) ) -RRB- cord-335975-m6lkrehi 3854 9 were be VBD cord-335975-m6lkrehi 3854 10 admitted admit VBN cord-335975-m6lkrehi 3854 11 after after IN cord-335975-m6lkrehi 3854 12 cardiac cardiac JJ cord-335975-m6lkrehi 3854 13 surgery surgery NN cord-335975-m6lkrehi 3854 14 and and CC cord-335975-m6lkrehi 3854 15 5 5 CD cord-335975-m6lkrehi 3854 16 had have VBD cord-335975-m6lkrehi 3854 17 a a DT cord-335975-m6lkrehi 3854 18 spontaneous spontaneous JJ cord-335975-m6lkrehi 3854 19 breathing breathing NN cord-335975-m6lkrehi 3854 20 activity activity NN cord-335975-m6lkrehi 3854 21 . . . cord-335975-m6lkrehi 3855 1 Median median JJ cord-335975-m6lkrehi 3855 2 PES PES NNP cord-335975-m6lkrehi 3855 3 measured measure VBN cord-335975-m6lkrehi 3855 4 by by IN cord-335975-m6lkrehi 3855 5 Gaeltec Gaeltec NNP cord-335975-m6lkrehi 3855 6 probe probe NN cord-335975-m6lkrehi 3855 7 and and CC cord-335975-m6lkrehi 3855 8 by by IN cord-335975-m6lkrehi 3855 9 feeding feed VBG cord-335975-m6lkrehi 3855 10 tube tube NN cord-335975-m6lkrehi 3855 11 was be VBD cord-335975-m6lkrehi 3855 12 2.3 2.3 CD cord-335975-m6lkrehi 3855 13 ( ( -LRB- cord-335975-m6lkrehi 3855 14 interquartile interquartile JJ cord-335975-m6lkrehi 3855 15 + + SYM cord-335975-m6lkrehi 3855 16 1.8 1.8 CD cord-335975-m6lkrehi 3855 17 - - SYM cord-335975-m6lkrehi 3855 18 5.4 5.4 CD cord-335975-m6lkrehi 3855 19 ) ) -RRB- cord-335975-m6lkrehi 3855 20 and and CC cord-335975-m6lkrehi 3855 21 7.9 7.9 CD cord-335975-m6lkrehi 3855 22 ( ( -LRB- cord-335975-m6lkrehi 3855 23 2.8 2.8 CD cord-335975-m6lkrehi 3855 24 - - SYM cord-335975-m6lkrehi 3855 25 9.5 9.5 CD cord-335975-m6lkrehi 3855 26 ) ) -RRB- cord-335975-m6lkrehi 3855 27 cm cm . cord-335975-m6lkrehi 3856 1 H h NN cord-335975-m6lkrehi 3856 2 2 2 CD cord-335975-m6lkrehi 3856 3 O o NN cord-335975-m6lkrehi 3856 4 , , , cord-335975-m6lkrehi 3856 5 respectively respectively RB cord-335975-m6lkrehi 3856 6 . . . cord-335975-m6lkrehi 3857 1 Median median JJ cord-335975-m6lkrehi 3857 2 PPL PPL NNS cord-335975-m6lkrehi 3857 3 measured measure VBD cord-335975-m6lkrehi 3857 4 into into IN cord-335975-m6lkrehi 3857 5 the the DT cord-335975-m6lkrehi 3857 6 chest chest NN cord-335975-m6lkrehi 3857 7 tube tube NN cord-335975-m6lkrehi 3857 8 was be VBD cord-335975-m6lkrehi 3857 9 4.0 4.0 CD cord-335975-m6lkrehi 3857 10 ( ( -LRB- cord-335975-m6lkrehi 3857 11 0.6 0.6 CD cord-335975-m6lkrehi 3857 12 - - SYM cord-335975-m6lkrehi 3857 13 9.6 9.6 CD cord-335975-m6lkrehi 3857 14 ) ) -RRB- cord-335975-m6lkrehi 3857 15 cm cm . cord-335975-m6lkrehi 3858 1 H h NN cord-335975-m6lkrehi 3858 2 2 2 CD cord-335975-m6lkrehi 3859 1 O. O. NNP cord-335975-m6lkrehi 3859 2 Bland Bland NNP cord-335975-m6lkrehi 3859 3 - - HYPH cord-335975-m6lkrehi 3859 4 Altman Altman NNP cord-335975-m6lkrehi 3859 5 plots plot NNS cord-335975-m6lkrehi 3859 6 are be VBP cord-335975-m6lkrehi 3859 7 represented represent VBN cord-335975-m6lkrehi 3859 8 in in IN cord-335975-m6lkrehi 3859 9 the the DT cord-335975-m6lkrehi 3859 10 figure figure NN cord-335975-m6lkrehi 3859 11 . . . cord-335975-m6lkrehi 3860 1 Conclusion conclusion NN cord-335975-m6lkrehi 3860 2 : : : cord-335975-m6lkrehi 3861 1 Both both DT cord-335975-m6lkrehi 3861 2 PPL PPL NNS cord-335975-m6lkrehi 3861 3 measured measure VBD cord-335975-m6lkrehi 3861 4 into into IN cord-335975-m6lkrehi 3861 5 the the DT cord-335975-m6lkrehi 3861 6 chest chest NN cord-335975-m6lkrehi 3861 7 tube tube NN cord-335975-m6lkrehi 3861 8 , , , cord-335975-m6lkrehi 3861 9 PES PES NNP cord-335975-m6lkrehi 3861 10 measured measure VBN cord-335975-m6lkrehi 3861 11 by by IN cord-335975-m6lkrehi 3861 12 the the DT cord-335975-m6lkrehi 3861 13 Gaeltec Gaeltec NNP cord-335975-m6lkrehi 3861 14 probe probe NN cord-335975-m6lkrehi 3861 15 or or CC cord-335975-m6lkrehi 3861 16 by by IN cord-335975-m6lkrehi 3861 17 the the DT cord-335975-m6lkrehi 3861 18 feeding feeding NN cord-335975-m6lkrehi 3861 19 tube tube NN cord-335975-m6lkrehi 3861 20 are be VBP cord-335975-m6lkrehi 3861 21 reproducible reproducible JJ cord-335975-m6lkrehi 3861 22 methods method NNS cord-335975-m6lkrehi 3861 23 . . . cord-335975-m6lkrehi 3861 24 . . . cord-335975-m6lkrehi 3862 1 Respiratory respiratory JJ cord-335975-m6lkrehi 3862 2 syncytial syncytial JJ cord-335975-m6lkrehi 3862 3 virus virus NN cord-335975-m6lkrehi 3862 4 was be VBD cord-335975-m6lkrehi 3862 5 identified identify VBN cord-335975-m6lkrehi 3862 6 in in IN cord-335975-m6lkrehi 3862 7 38 38 CD cord-335975-m6lkrehi 3862 8 infants infant NNS cord-335975-m6lkrehi 3862 9 ( ( -LRB- cord-335975-m6lkrehi 3862 10 70 70 CD cord-335975-m6lkrehi 3862 11 % % NN cord-335975-m6lkrehi 3862 12 ) ) -RRB- cord-335975-m6lkrehi 3862 13 . . . cord-335975-m6lkrehi 3863 1 An an DT cord-335975-m6lkrehi 3863 2 initial initial JJ cord-335975-m6lkrehi 3863 3 caffeine caffeine NN cord-335975-m6lkrehi 3863 4 citrate citrate NN cord-335975-m6lkrehi 3863 5 loading loading NN cord-335975-m6lkrehi 3863 6 dose dose NN cord-335975-m6lkrehi 3863 7 of of IN cord-335975-m6lkrehi 3863 8 20 20 CD cord-335975-m6lkrehi 3863 9 mg mg NNP cord-335975-m6lkrehi 3863 10 kg kg NNS cord-335975-m6lkrehi 3863 11 was be VBD cord-335975-m6lkrehi 3863 12 usually usually RB cord-335975-m6lkrehi 3863 13 administered administer VBN cord-335975-m6lkrehi 3863 14 , , , cord-335975-m6lkrehi 3863 15 followed follow VBN cord-335975-m6lkrehi 3863 16 by by IN cord-335975-m6lkrehi 3863 17 a a DT cord-335975-m6lkrehi 3863 18 5 5 CD cord-335975-m6lkrehi 3863 19 mg mg NNP cord-335975-m6lkrehi 3863 20 kg kg NNP cord-335975-m6lkrehi 3863 21 day day NN cord-335975-m6lkrehi 3863 22 maintenance maintenance NN cord-335975-m6lkrehi 3863 23 dose dose NN cord-335975-m6lkrehi 3863 24 , , , cord-335975-m6lkrehi 3863 25 for for IN cord-335975-m6lkrehi 3863 26 a a DT cord-335975-m6lkrehi 3863 27 median median JJ cord-335975-m6lkrehi 3863 28 treatment treatment NN cord-335975-m6lkrehi 3863 29 duration duration NN cord-335975-m6lkrehi 3863 30 of of IN cord-335975-m6lkrehi 3863 31 3 3 CD cord-335975-m6lkrehi 3863 32 days day NNS cord-335975-m6lkrehi 3863 33 [ [ -LRB- cord-335975-m6lkrehi 3863 34 1 1 CD cord-335975-m6lkrehi 3863 35 ] ] -RRB- cord-335975-m6lkrehi 3864 1 [ [ -LRB- cord-335975-m6lkrehi 3864 2 2 2 LS cord-335975-m6lkrehi 3864 3 ] ] -RRB- cord-335975-m6lkrehi 3864 4 [ [ -LRB- cord-335975-m6lkrehi 3864 5 3 3 CD cord-335975-m6lkrehi 3864 6 ] ] -RRB- cord-335975-m6lkrehi 3864 7 [ [ -LRB- cord-335975-m6lkrehi 3864 8 4 4 CD cord-335975-m6lkrehi 3864 9 ] ] -RRB- cord-335975-m6lkrehi 3864 10 [ [ -LRB- cord-335975-m6lkrehi 3864 11 5 5 CD cord-335975-m6lkrehi 3864 12 ] ] -RRB- cord-335975-m6lkrehi 3864 13 [ [ -LRB- cord-335975-m6lkrehi 3864 14 6 6 CD cord-335975-m6lkrehi 3864 15 ] ] -RRB- cord-335975-m6lkrehi 3864 16 . . . cord-335975-m6lkrehi 3865 1 Therapeutic therapeutic JJ cord-335975-m6lkrehi 3865 2 management management NN cord-335975-m6lkrehi 3865 3 ( ( -LRB- cord-335975-m6lkrehi 3865 4 invasive invasive JJ cord-335975-m6lkrehi 3865 5 and and CC cord-335975-m6lkrehi 3865 6 non non JJ cord-335975-m6lkrehi 3865 7 - - JJ cord-335975-m6lkrehi 3865 8 invasive invasive JJ cord-335975-m6lkrehi 3865 9 ventilation ventilation NN cord-335975-m6lkrehi 3865 10 , , , cord-335975-m6lkrehi 3865 11 nutrition nutrition NN cord-335975-m6lkrehi 3865 12 support support NN cord-335975-m6lkrehi 3865 13 ) ) -RRB- cord-335975-m6lkrehi 3865 14 and and CC cord-335975-m6lkrehi 3865 15 clinical clinical JJ cord-335975-m6lkrehi 3865 16 outcomes outcome NNS cord-335975-m6lkrehi 3865 17 ( ( -LRB- cord-335975-m6lkrehi 3865 18 death death NN cord-335975-m6lkrehi 3865 19 , , , cord-335975-m6lkrehi 3865 20 length length NN cord-335975-m6lkrehi 3865 21 of of IN cord-335975-m6lkrehi 3865 22 stay stay NN cord-335975-m6lkrehi 3865 23 ) ) -RRB- cord-335975-m6lkrehi 3865 24 were be VBD cord-335975-m6lkrehi 3865 25 similar similar JJ cord-335975-m6lkrehi 3865 26 between between IN cord-335975-m6lkrehi 3865 27 groups group NNS cord-335975-m6lkrehi 3865 28 . . . cord-335975-m6lkrehi 3866 1 There there EX cord-335975-m6lkrehi 3866 2 was be VBD cord-335975-m6lkrehi 3866 3 no no DT cord-335975-m6lkrehi 3866 4 difference difference NN cord-335975-m6lkrehi 3866 5 in in IN cord-335975-m6lkrehi 3866 6 potential potential JJ cord-335975-m6lkrehi 3866 7 caffeine caffeine NN cord-335975-m6lkrehi 3866 8 adverse adverse JJ cord-335975-m6lkrehi 3866 9 effects effect NNS cord-335975-m6lkrehi 3866 10 between between IN cord-335975-m6lkrehi 3866 11 groups group NNS cord-335975-m6lkrehi 3866 12 or or CC cord-335975-m6lkrehi 3866 13 within within IN cord-335975-m6lkrehi 3866 14 the the DT cord-335975-m6lkrehi 3866 15 caffeine caffeine NN cord-335975-m6lkrehi 3866 16 exposed expose VBN cord-335975-m6lkrehi 3866 17 group group NN cord-335975-m6lkrehi 3866 18 pre pre NN cord-335975-m6lkrehi 3866 19 and and CC cord-335975-m6lkrehi 3866 20 post post JJ cord-335975-m6lkrehi 3866 21 - - JJ cord-335975-m6lkrehi 3866 22 caffeine caffeine JJ cord-335975-m6lkrehi 3866 23 administration administration NN cord-335975-m6lkrehi 3866 24 . . . cord-335975-m6lkrehi 3867 1 Conclusion conclusion NN cord-335975-m6lkrehi 3867 2 : : : cord-335975-m6lkrehi 3868 1 Caffeine caffeine NN cord-335975-m6lkrehi 3868 2 treatment treatment NN cord-335975-m6lkrehi 3868 3 of of IN cord-335975-m6lkrehi 3868 4 bronchiolitis bronchiolitis NN cord-335975-m6lkrehi 3868 5 related relate VBN cord-335975-m6lkrehi 3868 6 apnea apnea NN cord-335975-m6lkrehi 3868 7 seems seem VBZ cord-335975-m6lkrehi 3868 8 to to TO cord-335975-m6lkrehi 3868 9 be be VB cord-335975-m6lkrehi 3868 10 a a DT cord-335975-m6lkrehi 3868 11 standard standard JJ cord-335975-m6lkrehi 3868 12 practice practice NN cord-335975-m6lkrehi 3868 13 in in IN cord-335975-m6lkrehi 3868 14 our -PRON- PRP$ cord-335975-m6lkrehi 3868 15 PICU PICU NNP cord-335975-m6lkrehi 3868 16 . . . cord-335975-m6lkrehi 3869 1 Our -PRON- PRP$ cord-335975-m6lkrehi 3869 2 study study NN cord-335975-m6lkrehi 3869 3 failed fail VBD cord-335975-m6lkrehi 3869 4 to to TO cord-335975-m6lkrehi 3869 5 show show VB cord-335975-m6lkrehi 3869 6 any any DT cord-335975-m6lkrehi 3869 7 influence influence NN cord-335975-m6lkrehi 3869 8 of of IN cord-335975-m6lkrehi 3869 9 caffeine caffeine NN cord-335975-m6lkrehi 3869 10 on on IN cord-335975-m6lkrehi 3869 11 clinical clinical JJ cord-335975-m6lkrehi 3869 12 outcomes outcome NNS cord-335975-m6lkrehi 3869 13 in in IN cord-335975-m6lkrehi 3869 14 this this DT cord-335975-m6lkrehi 3869 15 indication indication NN cord-335975-m6lkrehi 3869 16 when when WRB cord-335975-m6lkrehi 3869 17 compared compare VBN cord-335975-m6lkrehi 3869 18 with with IN cord-335975-m6lkrehi 3869 19 a a DT cord-335975-m6lkrehi 3869 20 small small JJ cord-335975-m6lkrehi 3869 21 number number NN cord-335975-m6lkrehi 3869 22 of of IN cord-335975-m6lkrehi 3869 23 patients patient NNS cord-335975-m6lkrehi 3869 24 . . . cord-335975-m6lkrehi 3870 1 Further further JJ cord-335975-m6lkrehi 3870 2 studies study NNS cord-335975-m6lkrehi 3870 3 are be VBP cord-335975-m6lkrehi 3870 4 needed need VBN cord-335975-m6lkrehi 3870 5 to to TO cord-335975-m6lkrehi 3870 6 assess assess VB cord-335975-m6lkrehi 3870 7 the the DT cord-335975-m6lkrehi 3870 8 efficacy efficacy NN cord-335975-m6lkrehi 3870 9 and and CC cord-335975-m6lkrehi 3870 10 safety safety NN cord-335975-m6lkrehi 3870 11 of of IN cord-335975-m6lkrehi 3870 12 caffeine caffeine NN cord-335975-m6lkrehi 3870 13 treatment treatment NN cord-335975-m6lkrehi 3870 14 in in IN cord-335975-m6lkrehi 3870 15 this this DT cord-335975-m6lkrehi 3870 16 indication indication NN cord-335975-m6lkrehi 3870 17 as as RB cord-335975-m6lkrehi 3870 18 well well RB cord-335975-m6lkrehi 3870 19 as as IN cord-335975-m6lkrehi 3870 20 the the DT cord-335975-m6lkrehi 3870 21 appropriate appropriate JJ cord-335975-m6lkrehi 3870 22 treatment treatment NN cord-335975-m6lkrehi 3870 23 regimen regimen NN cord-335975-m6lkrehi 3870 24 as as IN cord-335975-m6lkrehi 3870 25 pharmacokinetic pharmacokinetic JJ cord-335975-m6lkrehi 3870 26 data datum NNS cord-335975-m6lkrehi 3870 27 suggest suggest VBP cord-335975-m6lkrehi 3870 28 that that IN cord-335975-m6lkrehi 3870 29 higher high JJR cord-335975-m6lkrehi 3870 30 dose dose NN cord-335975-m6lkrehi 3870 31 could could MD cord-335975-m6lkrehi 3870 32 be be VB cord-335975-m6lkrehi 3870 33 of of IN cord-335975-m6lkrehi 3870 34 great great JJ cord-335975-m6lkrehi 3870 35 interest interest NN cord-335975-m6lkrehi 3870 36 in in IN cord-335975-m6lkrehi 3870 37 this this DT cord-335975-m6lkrehi 3870 38 non non JJ cord-335975-m6lkrehi 3870 39 - - JJ cord-335975-m6lkrehi 3870 40 prematurely prematurely RB cord-335975-m6lkrehi 3870 41 born bear VBN cord-335975-m6lkrehi 3870 42 population population NN cord-335975-m6lkrehi 3870 43 . . . cord-335975-m6lkrehi 3871 1 Introduction introduction NN cord-335975-m6lkrehi 3871 2 : : : cord-335975-m6lkrehi 3872 1 During during IN cord-335975-m6lkrehi 3872 2 the the DT cord-335975-m6lkrehi 3872 3 last last JJ cord-335975-m6lkrehi 3872 4 decade decade NN cord-335975-m6lkrehi 3872 5 , , , cord-335975-m6lkrehi 3872 6 many many JJ cord-335975-m6lkrehi 3872 7 authors author NNS cord-335975-m6lkrehi 3872 8 have have VBP cord-335975-m6lkrehi 3872 9 raised raise VBN cord-335975-m6lkrehi 3872 10 awareness awareness NN cord-335975-m6lkrehi 3872 11 concerning concern VBG cord-335975-m6lkrehi 3872 12 the the DT cord-335975-m6lkrehi 3872 13 increasing increase VBG cord-335975-m6lkrehi 3872 14 rate rate NN cord-335975-m6lkrehi 3872 15 of of IN cord-335975-m6lkrehi 3872 16 venous venous JJ cord-335975-m6lkrehi 3872 17 thromboembolism thromboembolism NN cord-335975-m6lkrehi 3872 18 ( ( -LRB- cord-335975-m6lkrehi 3872 19 VTE VTE NNP cord-335975-m6lkrehi 3872 20 ) ) -RRB- cord-335975-m6lkrehi 3872 21 in in IN cord-335975-m6lkrehi 3872 22 critically critically RB cord-335975-m6lkrehi 3872 23 ill ill JJ cord-335975-m6lkrehi 3872 24 children child NNS cord-335975-m6lkrehi 3872 25 [ [ -LRB- cord-335975-m6lkrehi 3872 26 1 1 CD cord-335975-m6lkrehi 3872 27 ] ] -RRB- cord-335975-m6lkrehi 3872 28 . . . cord-335975-m6lkrehi 3873 1 The the DT cord-335975-m6lkrehi 3873 2 presence presence NN cord-335975-m6lkrehi 3873 3 of of IN cord-335975-m6lkrehi 3873 4 central central JJ cord-335975-m6lkrehi 3873 5 venous venous JJ cord-335975-m6lkrehi 3873 6 catheter catheter NN cord-335975-m6lkrehi 3873 7 ( ( -LRB- cord-335975-m6lkrehi 3873 8 CVC CVC NNP cord-335975-m6lkrehi 3873 9 ) ) -RRB- cord-335975-m6lkrehi 3873 10 is be VBZ cord-335975-m6lkrehi 3873 11 one one CD cord-335975-m6lkrehi 3873 12 of of IN cord-335975-m6lkrehi 3873 13 the the DT cord-335975-m6lkrehi 3873 14 most most RBS cord-335975-m6lkrehi 3873 15 important important JJ cord-335975-m6lkrehi 3873 16 risk risk NN cord-335975-m6lkrehi 3873 17 factor factor NN cord-335975-m6lkrehi 3873 18 for for IN cord-335975-m6lkrehi 3873 19 venous venous JJ cord-335975-m6lkrehi 3873 20 thrombosis thrombosis NN cord-335975-m6lkrehi 3873 21 in in IN cord-335975-m6lkrehi 3873 22 children child NNS cord-335975-m6lkrehi 3873 23 [ [ -LRB- cord-335975-m6lkrehi 3873 24 2 2 CD cord-335975-m6lkrehi 3873 25 ] ] -RRB- cord-335975-m6lkrehi 3873 26 . . . cord-335975-m6lkrehi 3874 1 The the DT cord-335975-m6lkrehi 3874 2 purpose purpose NN cord-335975-m6lkrehi 3874 3 of of IN cord-335975-m6lkrehi 3874 4 this this DT cord-335975-m6lkrehi 3874 5 study study NN cord-335975-m6lkrehi 3874 6 was be VBD cord-335975-m6lkrehi 3874 7 to to TO cord-335975-m6lkrehi 3874 8 analyze analyze VB cord-335975-m6lkrehi 3874 9 incidence incidence NN cord-335975-m6lkrehi 3874 10 and and CC cord-335975-m6lkrehi 3874 11 risk risk NN cord-335975-m6lkrehi 3874 12 factors factor NNS cord-335975-m6lkrehi 3874 13 for for IN cord-335975-m6lkrehi 3874 14 catheter catheter NN cord-335975-m6lkrehi 3874 15 - - HYPH cord-335975-m6lkrehi 3874 16 related relate VBN cord-335975-m6lkrehi 3874 17 thrombosis thrombosis NN cord-335975-m6lkrehi 3874 18 in in IN cord-335975-m6lkrehi 3874 19 children child NNS cord-335975-m6lkrehi 3874 20 admitted admit VBN cord-335975-m6lkrehi 3874 21 in in IN cord-335975-m6lkrehi 3874 22 our -PRON- PRP$ cord-335975-m6lkrehi 3874 23 Pediatric Pediatric NNP cord-335975-m6lkrehi 3874 24 Intensive Intensive NNP cord-335975-m6lkrehi 3874 25 Care Care NNP cord-335975-m6lkrehi 3874 26 Unit Unit NNP cord-335975-m6lkrehi 3874 27 ( ( -LRB- cord-335975-m6lkrehi 3874 28 PICU PICU NNP cord-335975-m6lkrehi 3874 29 ) ) -RRB- cord-335975-m6lkrehi 3874 30 . . . cord-335975-m6lkrehi 3875 1 Patients patient NNS cord-335975-m6lkrehi 3875 2 and and CC cord-335975-m6lkrehi 3875 3 methods method NNS cord-335975-m6lkrehi 3875 4 : : : cord-335975-m6lkrehi 3875 5 All all DT cord-335975-m6lkrehi 3875 6 children child NNS cord-335975-m6lkrehi 3875 7 aged age VBN cord-335975-m6lkrehi 3875 8 less less JJR cord-335975-m6lkrehi 3875 9 than than IN cord-335975-m6lkrehi 3875 10 2 2 CD cord-335975-m6lkrehi 3875 11 years year NNS cord-335975-m6lkrehi 3875 12 , , , cord-335975-m6lkrehi 3875 13 admitted admit VBN cord-335975-m6lkrehi 3875 14 in in IN cord-335975-m6lkrehi 3875 15 the the DT cord-335975-m6lkrehi 3875 16 PICU PICU NNP cord-335975-m6lkrehi 3875 17 from from IN cord-335975-m6lkrehi 3875 18 January January NNP cord-335975-m6lkrehi 3875 19 2016 2016 CD cord-335975-m6lkrehi 3875 20 to to IN cord-335975-m6lkrehi 3875 21 June June NNP cord-335975-m6lkrehi 3875 22 2017 2017 CD cord-335975-m6lkrehi 3875 23 , , , cord-335975-m6lkrehi 3875 24 and and CC cord-335975-m6lkrehi 3875 25 receiving receive VBG cord-335975-m6lkrehi 3875 26 at at RB cord-335975-m6lkrehi 3875 27 least least RBS cord-335975-m6lkrehi 3875 28 one one CD cord-335975-m6lkrehi 3875 29 tunneled tunnel VBN cord-335975-m6lkrehi 3875 30 CVC CVC NNP cord-335975-m6lkrehi 3875 31 , , , cord-335975-m6lkrehi 3875 32 were be VBD cord-335975-m6lkrehi 3875 33 included include VBN cord-335975-m6lkrehi 3875 34 in in IN cord-335975-m6lkrehi 3875 35 our -PRON- PRP$ cord-335975-m6lkrehi 3875 36 retrospective retrospective JJ cord-335975-m6lkrehi 3875 37 study study NN cord-335975-m6lkrehi 3875 38 . . . cord-335975-m6lkrehi 3876 1 Those those DT cord-335975-m6lkrehi 3876 2 with with IN cord-335975-m6lkrehi 3876 3 venous venous JJ cord-335975-m6lkrehi 3876 4 thrombosis thrombosis NN cord-335975-m6lkrehi 3876 5 unrelated unrelated JJ cord-335975-m6lkrehi 3876 6 to to IN cord-335975-m6lkrehi 3876 7 CVC CVC NNP cord-335975-m6lkrehi 3876 8 placement placement NN cord-335975-m6lkrehi 3876 9 were be VBD cord-335975-m6lkrehi 3876 10 excluded exclude VBN cord-335975-m6lkrehi 3876 11 . . . cord-335975-m6lkrehi 3877 1 Catheter catheter NN cord-335975-m6lkrehi 3877 2 - - HYPH cord-335975-m6lkrehi 3877 3 associated associate VBN cord-335975-m6lkrehi 3877 4 venous venous JJ cord-335975-m6lkrehi 3877 5 thrombosis thrombosis NN cord-335975-m6lkrehi 3877 6 ( ( -LRB- cord-335975-m6lkrehi 3877 7 CAVT CAVT NNP cord-335975-m6lkrehi 3877 8 ) ) -RRB- cord-335975-m6lkrehi 3877 9 was be VBD cord-335975-m6lkrehi 3877 10 confirmed confirm VBN cord-335975-m6lkrehi 3877 11 using use VBG cord-335975-m6lkrehi 3877 12 Doppler Doppler NNP cord-335975-m6lkrehi 3877 13 ultrasonography ultrasonography NN cord-335975-m6lkrehi 3877 14 . . . cord-335975-m6lkrehi 3878 1 Introduction introduction NN cord-335975-m6lkrehi 3878 2 : : : cord-335975-m6lkrehi 3879 1 Weaning wean VBG cord-335975-m6lkrehi 3879 2 from from IN cord-335975-m6lkrehi 3879 3 the the DT cord-335975-m6lkrehi 3879 4 ventilation ventilation NN cord-335975-m6lkrehi 3879 5 is be VBZ cord-335975-m6lkrehi 3879 6 a a DT cord-335975-m6lkrehi 3879 7 crucial crucial JJ cord-335975-m6lkrehi 3879 8 moment moment NN cord-335975-m6lkrehi 3879 9 in in IN cord-335975-m6lkrehi 3879 10 the the DT cord-335975-m6lkrehi 3879 11 ICU ICU NNP cord-335975-m6lkrehi 3879 12 stay stay NN cord-335975-m6lkrehi 3879 13 . . . cord-335975-m6lkrehi 3880 1 Because because IN cord-335975-m6lkrehi 3880 2 of of IN cord-335975-m6lkrehi 3880 3 the the DT cord-335975-m6lkrehi 3880 4 risks risk NNS cord-335975-m6lkrehi 3880 5 of of IN cord-335975-m6lkrehi 3880 6 mechanical mechanical JJ cord-335975-m6lkrehi 3880 7 ventilation ventilation NN cord-335975-m6lkrehi 3880 8 ( ( -LRB- cord-335975-m6lkrehi 3880 9 MV MV NNP cord-335975-m6lkrehi 3880 10 ) ) -RRB- cord-335975-m6lkrehi 3880 11 , , , cord-335975-m6lkrehi 3880 12 such such JJ cord-335975-m6lkrehi 3880 13 as as IN cord-335975-m6lkrehi 3880 14 ventilator ventilator NN cord-335975-m6lkrehi 3880 15 - - HYPH cord-335975-m6lkrehi 3880 16 associated associate VBN cord-335975-m6lkrehi 3880 17 pneumoniae pneumoniae NN cord-335975-m6lkrehi 3880 18 , , , cord-335975-m6lkrehi 3880 19 it -PRON- PRP cord-335975-m6lkrehi 3880 20 is be VBZ cord-335975-m6lkrehi 3880 21 recommended recommend VBN cord-335975-m6lkrehi 3880 22 to to TO cord-335975-m6lkrehi 3880 23 begin begin VB cord-335975-m6lkrehi 3880 24 the the DT cord-335975-m6lkrehi 3880 25 weaning weaning NN cord-335975-m6lkrehi 3880 26 process process NN cord-335975-m6lkrehi 3880 27 as as RB cord-335975-m6lkrehi 3880 28 soon soon RB cord-335975-m6lkrehi 3880 29 as as IN cord-335975-m6lkrehi 3880 30 weaning wean VBG cord-335975-m6lkrehi 3880 31 criteria criterion NNS cord-335975-m6lkrehi 3880 32 occurs occur VBZ cord-335975-m6lkrehi 3880 33 [ [ -LRB- cord-335975-m6lkrehi 3880 34 1 1 CD cord-335975-m6lkrehi 3880 35 ] ] -RRB- cord-335975-m6lkrehi 3880 36 . . . cord-335975-m6lkrehi 3881 1 However however RB cord-335975-m6lkrehi 3881 2 , , , cord-335975-m6lkrehi 3881 3 extubation extubation NN cord-335975-m6lkrehi 3881 4 is be VBZ cord-335975-m6lkrehi 3881 5 also also RB cord-335975-m6lkrehi 3881 6 a a DT cord-335975-m6lkrehi 3881 7 hazardous hazardous JJ cord-335975-m6lkrehi 3881 8 period period NN cord-335975-m6lkrehi 3881 9 , , , cord-335975-m6lkrehi 3881 10 with with IN cord-335975-m6lkrehi 3881 11 5 5 CD cord-335975-m6lkrehi 3881 12 to to TO cord-335975-m6lkrehi 3881 13 15 15 CD cord-335975-m6lkrehi 3881 14 % % NN cord-335975-m6lkrehi 3881 15 of of IN cord-335975-m6lkrehi 3881 16 subsequent subsequent JJ cord-335975-m6lkrehi 3881 17 respiratory respiratory JJ cord-335975-m6lkrehi 3881 18 failure failure NN cord-335975-m6lkrehi 3881 19 requiring require VBG cord-335975-m6lkrehi 3881 20 reintubation reintubation NN cord-335975-m6lkrehi 3881 21 , , , cord-335975-m6lkrehi 3881 22 harboring harbor VBG cord-335975-m6lkrehi 3881 23 a a DT cord-335975-m6lkrehi 3881 24 dismal dismal JJ cord-335975-m6lkrehi 3881 25 prognosis prognosis NN cord-335975-m6lkrehi 3881 26 [ [ -LRB- cord-335975-m6lkrehi 3881 27 2 2 CD cord-335975-m6lkrehi 3881 28 ] ] -RRB- cord-335975-m6lkrehi 3881 29 . . . cord-335975-m6lkrehi 3882 1 International international JJ cord-335975-m6lkrehi 3882 2 guidelines guideline NNS cord-335975-m6lkrehi 3882 3 display display VBP cord-335975-m6lkrehi 3882 4 the the DT cord-335975-m6lkrehi 3882 5 criteria criterion NNS cord-335975-m6lkrehi 3882 6 triggering trigger VBG cord-335975-m6lkrehi 3882 7 the the DT cord-335975-m6lkrehi 3882 8 extubation extubation NN cord-335975-m6lkrehi 3882 9 . . . cord-335975-m6lkrehi 3883 1 Nevertheless nevertheless RB cord-335975-m6lkrehi 3883 2 , , , cord-335975-m6lkrehi 3883 3 the the DT cord-335975-m6lkrehi 3883 4 physician physician NN cord-335975-m6lkrehi 3883 5 in in IN cord-335975-m6lkrehi 3883 6 charge charge NN cord-335975-m6lkrehi 3883 7 eventually eventually RB cord-335975-m6lkrehi 3883 8 takes take VBZ cord-335975-m6lkrehi 3883 9 the the DT cord-335975-m6lkrehi 3883 10 decision decision NN cord-335975-m6lkrehi 3883 11 to to IN cord-335975-m6lkrehi 3883 12 extubate extubate NNP cord-335975-m6lkrehi 3883 13 . . . cord-335975-m6lkrehi 3884 1 In in IN cord-335975-m6lkrehi 3884 2 this this DT cord-335975-m6lkrehi 3884 3 regard regard NN cord-335975-m6lkrehi 3884 4 , , , cord-335975-m6lkrehi 3884 5 there there EX cord-335975-m6lkrehi 3884 6 could could MD cord-335975-m6lkrehi 3884 7 be be VB cord-335975-m6lkrehi 3884 8 variations variation NNS cord-335975-m6lkrehi 3884 9 from from IN cord-335975-m6lkrehi 3884 10 an an DT cord-335975-m6lkrehi 3884 11 individual individual NN cord-335975-m6lkrehi 3884 12 to to IN cord-335975-m6lkrehi 3884 13 another another DT cord-335975-m6lkrehi 3884 14 . . . cord-335975-m6lkrehi 3885 1 The the DT cord-335975-m6lkrehi 3885 2 main main JJ cord-335975-m6lkrehi 3885 3 goal goal NN cord-335975-m6lkrehi 3885 4 of of IN cord-335975-m6lkrehi 3885 5 our -PRON- PRP$ cord-335975-m6lkrehi 3885 6 study study NN cord-335975-m6lkrehi 3885 7 was be VBD cord-335975-m6lkrehi 3885 8 to to TO cord-335975-m6lkrehi 3885 9 identify identify VB cord-335975-m6lkrehi 3885 10 the the DT cord-335975-m6lkrehi 3885 11 perceived perceive VBN cord-335975-m6lkrehi 3885 12 impediments impediment NNS cord-335975-m6lkrehi 3885 13 to to IN cord-335975-m6lkrehi 3885 14 MV MV NNP cord-335975-m6lkrehi 3885 15 weaning wean VBG cord-335975-m6lkrehi 3885 16 among among IN cord-335975-m6lkrehi 3885 17 physicians physician NNS cord-335975-m6lkrehi 3885 18 , , , cord-335975-m6lkrehi 3885 19 from from IN cord-335975-m6lkrehi 3885 20 intubation intubation NN cord-335975-m6lkrehi 3885 21 to to IN cord-335975-m6lkrehi 3885 22 extubation extubation NN cord-335975-m6lkrehi 3885 23 . . . cord-335975-m6lkrehi 3886 1 Patients patient NNS cord-335975-m6lkrehi 3886 2 and and CC cord-335975-m6lkrehi 3886 3 methods method NNS cord-335975-m6lkrehi 3886 4 : : : cord-335975-m6lkrehi 3886 5 Prospective prospective JJ cord-335975-m6lkrehi 3886 6 single single JJ cord-335975-m6lkrehi 3886 7 center center NN cord-335975-m6lkrehi 3886 8 study study NN cord-335975-m6lkrehi 3886 9 in in IN cord-335975-m6lkrehi 3886 10 a a DT cord-335975-m6lkrehi 3886 11 12 12 CD cord-335975-m6lkrehi 3886 12 bed bed NN cord-335975-m6lkrehi 3886 13 university university NN cord-335975-m6lkrehi 3886 14 ICU ICU NNP cord-335975-m6lkrehi 3886 15 . . . cord-335975-m6lkrehi 3887 1 All all DT cord-335975-m6lkrehi 3887 2 patients patient NNS cord-335975-m6lkrehi 3887 3 admitted admit VBD cord-335975-m6lkrehi 3887 4 between between IN cord-335975-m6lkrehi 3887 5 February February NNP cord-335975-m6lkrehi 3887 6 and and CC cord-335975-m6lkrehi 3887 7 May May NNP cord-335975-m6lkrehi 3887 8 2017 2017 CD cord-335975-m6lkrehi 3887 9 and and CC cord-335975-m6lkrehi 3887 10 undergoing undergo VBG cord-335975-m6lkrehi 3887 11 MV MV NNP cord-335975-m6lkrehi 3887 12 were be VBD cord-335975-m6lkrehi 3887 13 included include VBN cord-335975-m6lkrehi 3887 14 . . . cord-335975-m6lkrehi 3888 1 We -PRON- PRP cord-335975-m6lkrehi 3888 2 daily daily RB cord-335975-m6lkrehi 3888 3 registered register VBD cord-335975-m6lkrehi 3888 4 the the DT cord-335975-m6lkrehi 3888 5 existence existence NN cord-335975-m6lkrehi 3888 6 of of IN cord-335975-m6lkrehi 3888 7 the the DT cord-335975-m6lkrehi 3888 8 criteria criterion NNS cord-335975-m6lkrehi 3888 9 recommending recommend VBG cord-335975-m6lkrehi 3888 10 a a DT cord-335975-m6lkrehi 3888 11 spontaneous spontaneous JJ cord-335975-m6lkrehi 3888 12 breathing breathing NN cord-335975-m6lkrehi 3888 13 trial trial NN cord-335975-m6lkrehi 3888 14 ( ( -LRB- cord-335975-m6lkrehi 3888 15 SBT SBT NNP cord-335975-m6lkrehi 3888 16 ) ) -RRB- cord-335975-m6lkrehi 3888 17 , , , cord-335975-m6lkrehi 3888 18 the the DT cord-335975-m6lkrehi 3888 19 occurrence occurrence NN cord-335975-m6lkrehi 3888 20 of of IN cord-335975-m6lkrehi 3888 21 a a DT cord-335975-m6lkrehi 3888 22 SBT SBT NNP cord-335975-m6lkrehi 3888 23 , , , cord-335975-m6lkrehi 3888 24 the the DT cord-335975-m6lkrehi 3888 25 items item NNS cord-335975-m6lkrehi 3888 26 recommending recommend VBG cord-335975-m6lkrehi 3888 27 postponing postpone VBG cord-335975-m6lkrehi 3888 28 extubation extubation NN cord-335975-m6lkrehi 3888 29 , , , cord-335975-m6lkrehi 3888 30 and and CC cord-335975-m6lkrehi 3888 31 the the DT cord-335975-m6lkrehi 3888 32 occurrence occurrence NN cord-335975-m6lkrehi 3888 33 of of IN cord-335975-m6lkrehi 3888 34 an an DT cord-335975-m6lkrehi 3888 35 extubation extubation NN cord-335975-m6lkrehi 3888 36 . . . cord-335975-m6lkrehi 3889 1 The the DT cord-335975-m6lkrehi 3889 2 estimated estimate VBN cord-335975-m6lkrehi 3889 3 reasons reason NNS cord-335975-m6lkrehi 3889 4 for for IN cord-335975-m6lkrehi 3889 5 all all PDT cord-335975-m6lkrehi 3889 6 the the DT cord-335975-m6lkrehi 3889 7 aforementioned aforementioned JJ cord-335975-m6lkrehi 3889 8 decisions decision NNS cord-335975-m6lkrehi 3889 9 were be VBD cord-335975-m6lkrehi 3889 10 asked ask VBN cord-335975-m6lkrehi 3889 11 to to IN cord-335975-m6lkrehi 3889 12 the the DT cord-335975-m6lkrehi 3889 13 physician physician NN cord-335975-m6lkrehi 3889 14 in in IN cord-335975-m6lkrehi 3889 15 charge charge NN cord-335975-m6lkrehi 3889 16 . . . cord-335975-m6lkrehi 3890 1 Results result NNS cord-335975-m6lkrehi 3890 2 : : : cord-335975-m6lkrehi 3890 3 25 25 CD cord-335975-m6lkrehi 3890 4 patients patient NNS cord-335975-m6lkrehi 3890 5 were be VBD cord-335975-m6lkrehi 3890 6 included include VBN cord-335975-m6lkrehi 3890 7 , , , cord-335975-m6lkrehi 3890 8 gathering gather VBG cord-335975-m6lkrehi 3890 9 298 298 CD cord-335975-m6lkrehi 3890 10 days day NNS cord-335975-m6lkrehi 3890 11 of of IN cord-335975-m6lkrehi 3890 12 MV MV NNP cord-335975-m6lkrehi 3890 13 and and CC cord-335975-m6lkrehi 3890 14 42 42 CD cord-335975-m6lkrehi 3890 15 SBT SBT NNP cord-335975-m6lkrehi 3890 16 . . . cord-335975-m6lkrehi 3891 1 The the DT cord-335975-m6lkrehi 3891 2 average average JJ cord-335975-m6lkrehi 3891 3 duration duration NN cord-335975-m6lkrehi 3891 4 of of IN cord-335975-m6lkrehi 3891 5 MV MV NNP cord-335975-m6lkrehi 3891 6 was be VBD cord-335975-m6lkrehi 3891 7 8.25 8.25 CD cord-335975-m6lkrehi 3891 8 ± ± NNP cord-335975-m6lkrehi 3891 9 9.4 9.4 CD cord-335975-m6lkrehi 3891 10 days day NNS cord-335975-m6lkrehi 3891 11 . . . cord-335975-m6lkrehi 3892 1 There there EX cord-335975-m6lkrehi 3892 2 was be VBD cord-335975-m6lkrehi 3892 3 one one CD cord-335975-m6lkrehi 3892 4 extubation extubation NN cord-335975-m6lkrehi 3892 5 failure failure NN cord-335975-m6lkrehi 3892 6 requiring require VBG cord-335975-m6lkrehi 3892 7 reintubation reintubation NN cord-335975-m6lkrehi 3892 8 . . . cord-335975-m6lkrehi 3893 1 There there EX cord-335975-m6lkrehi 3893 2 were be VBD cord-335975-m6lkrehi 3893 3 9 9 CD cord-335975-m6lkrehi 3893 4 SBT SBT NNP cord-335975-m6lkrehi 3893 5 failures failure NNS cord-335975-m6lkrehi 3893 6 . . . cord-335975-m6lkrehi 3894 1 In in IN cord-335975-m6lkrehi 3894 2 9 9 CD cord-335975-m6lkrehi 3894 3 cases case NNS cord-335975-m6lkrehi 3894 4 , , , cord-335975-m6lkrehi 3894 5 SBT SBT NNP cord-335975-m6lkrehi 3894 6 was be VBD cord-335975-m6lkrehi 3894 7 a a DT cord-335975-m6lkrehi 3894 8 success success NN cord-335975-m6lkrehi 3894 9 but but CC cord-335975-m6lkrehi 3894 10 did do VBD cord-335975-m6lkrehi 3894 11 not not RB cord-335975-m6lkrehi 3894 12 lead lead VB cord-335975-m6lkrehi 3894 13 to to IN cord-335975-m6lkrehi 3894 14 extubation extubation NN cord-335975-m6lkrehi 3894 15 because because IN cord-335975-m6lkrehi 3894 16 of of IN cord-335975-m6lkrehi 3894 17 hypotonia hypotonia NNS cord-335975-m6lkrehi 3894 18 , , , cord-335975-m6lkrehi 3894 19 weak weak JJ cord-335975-m6lkrehi 3894 20 cough cough NN cord-335975-m6lkrehi 3894 21 , , , cord-335975-m6lkrehi 3894 22 subsequent subsequent JJ cord-335975-m6lkrehi 3894 23 respiratory respiratory JJ cord-335975-m6lkrehi 3894 24 failure failure NN cord-335975-m6lkrehi 3894 25 , , , cord-335975-m6lkrehi 3894 26 hemorrhagic hemorrhagic JJ cord-335975-m6lkrehi 3894 27 bronchial bronchial JJ cord-335975-m6lkrehi 3894 28 secretions secretion NNS cord-335975-m6lkrehi 3894 29 , , , cord-335975-m6lkrehi 3894 30 hemodynamic hemodynamic JJ cord-335975-m6lkrehi 3894 31 instability instability NN cord-335975-m6lkrehi 3894 32 , , , cord-335975-m6lkrehi 3894 33 absence absence NN cord-335975-m6lkrehi 3894 34 of of IN cord-335975-m6lkrehi 3894 35 weaning wean VBG cord-335975-m6lkrehi 3894 36 criteria criterion NNS cord-335975-m6lkrehi 3894 37 , , , cord-335975-m6lkrehi 3894 38 drowsiness drowsiness NN cord-335975-m6lkrehi 3894 39 ( ( -LRB- cord-335975-m6lkrehi 3894 40 all all PDT cord-335975-m6lkrehi 3894 41 the the DT cord-335975-m6lkrehi 3894 42 aforementioned aforementioned JJ cord-335975-m6lkrehi 3894 43 n n NN cord-335975-m6lkrehi 3894 44 = = SYM cord-335975-m6lkrehi 3894 45 1 1 CD cord-335975-m6lkrehi 3894 46 ) ) -RRB- cord-335975-m6lkrehi 3894 47 , , , cord-335975-m6lkrehi 3894 48 post post NN cord-335975-m6lkrehi 3894 49 SBT SBT NNP cord-335975-m6lkrehi 3894 50 hypercapnia hypercapnia NN cord-335975-m6lkrehi 3894 51 ( ( -LRB- cord-335975-m6lkrehi 3894 52 n n NN cord-335975-m6lkrehi 3894 53 = = SYM cord-335975-m6lkrehi 3894 54 2 2 CD cord-335975-m6lkrehi 3894 55 ) ) -RRB- cord-335975-m6lkrehi 3894 56 . . . cord-335975-m6lkrehi 3895 1 23 23 CD cord-335975-m6lkrehi 3895 2 out out IN cord-335975-m6lkrehi 3895 3 of of IN cord-335975-m6lkrehi 3895 4 the the DT cord-335975-m6lkrehi 3895 5 42 42 CD cord-335975-m6lkrehi 3895 6 SBT SBT NNP cord-335975-m6lkrehi 3895 7 ( ( -LRB- cord-335975-m6lkrehi 3895 8 55 55 CD cord-335975-m6lkrehi 3895 9 % % NN cord-335975-m6lkrehi 3895 10 ) ) -RRB- cord-335975-m6lkrehi 3895 11 were be VBD cord-335975-m6lkrehi 3895 12 done do VBN cord-335975-m6lkrehi 3895 13 while while IN cord-335975-m6lkrehi 3895 14 one one CD cord-335975-m6lkrehi 3895 15 or or CC cord-335975-m6lkrehi 3895 16 several several JJ cord-335975-m6lkrehi 3895 17 weaning wean VBG cord-335975-m6lkrehi 3895 18 criteria criterion NNS cord-335975-m6lkrehi 3895 19 were be VBD cord-335975-m6lkrehi 3895 20 absent absent JJ cord-335975-m6lkrehi 3895 21 . . . cord-335975-m6lkrehi 3896 1 Impediments impediment NNS cord-335975-m6lkrehi 3896 2 to to IN cord-335975-m6lkrehi 3896 3 weaning wean VBG cord-335975-m6lkrehi 3896 4 trials trial NNS cord-335975-m6lkrehi 3896 5 were be VBD cord-335975-m6lkrehi 3896 6 different different JJ cord-335975-m6lkrehi 3896 7 according accord VBG cord-335975-m6lkrehi 3896 8 to to IN cord-335975-m6lkrehi 3896 9 the the DT cord-335975-m6lkrehi 3896 10 time time NN cord-335975-m6lkrehi 3896 11 lag lag VB cord-335975-m6lkrehi 3896 12 since since IN cord-335975-m6lkrehi 3896 13 ICU ICU NNP cord-335975-m6lkrehi 3896 14 admission admission NN cord-335975-m6lkrehi 3896 15 , , , cord-335975-m6lkrehi 3896 16 with with IN cord-335975-m6lkrehi 3896 17 fluid fluid JJ cord-335975-m6lkrehi 3896 18 overload overload NN cord-335975-m6lkrehi 3896 19 , , , cord-335975-m6lkrehi 3896 20 muscular muscular JJ cord-335975-m6lkrehi 3896 21 weakness weakness NN cord-335975-m6lkrehi 3896 22 and and CC cord-335975-m6lkrehi 3896 23 persistent persistent JJ cord-335975-m6lkrehi 3896 24 need need NN cord-335975-m6lkrehi 3896 25 for for IN cord-335975-m6lkrehi 3896 26 assist assist VB cord-335975-m6lkrehi 3896 27 control control NN cord-335975-m6lkrehi 3896 28 ventilation ventilation NN cord-335975-m6lkrehi 3896 29 settings setting NNS cord-335975-m6lkrehi 3896 30 being be VBG cord-335975-m6lkrehi 3896 31 the the DT cord-335975-m6lkrehi 3896 32 most most RBS cord-335975-m6lkrehi 3896 33 frequent frequent JJ cord-335975-m6lkrehi 3896 34 reasons reason NNS cord-335975-m6lkrehi 3896 35 advocated advocate VBN cord-335975-m6lkrehi 3896 36 after after IN cord-335975-m6lkrehi 3896 37 7 7 CD cord-335975-m6lkrehi 3896 38 days day NNS cord-335975-m6lkrehi 3896 39 ( ( -LRB- cord-335975-m6lkrehi 3896 40 figure figure NN cord-335975-m6lkrehi 3896 41 ) ) -RRB- cord-335975-m6lkrehi 3896 42 . . . cord-335975-m6lkrehi 3897 1 No no DT cord-335975-m6lkrehi 3897 2 objective objective JJ cord-335975-m6lkrehi 3897 3 assessment assessment NN cord-335975-m6lkrehi 3897 4 of of IN cord-335975-m6lkrehi 3897 5 muscular muscular JJ cord-335975-m6lkrehi 3897 6 or or CC cord-335975-m6lkrehi 3897 7 cough cough NN cord-335975-m6lkrehi 3897 8 strength strength NN cord-335975-m6lkrehi 3897 9 was be VBD cord-335975-m6lkrehi 3897 10 performed perform VBN cord-335975-m6lkrehi 3897 11 at at IN cord-335975-m6lkrehi 3897 12 any any DT cord-335975-m6lkrehi 3897 13 time time NN cord-335975-m6lkrehi 3897 14 , , , cord-335975-m6lkrehi 3897 15 neither neither DT cord-335975-m6lkrehi 3897 16 was be VBD cord-335975-m6lkrehi 3897 17 monitored monitor VBN cord-335975-m6lkrehi 3897 18 the the DT cord-335975-m6lkrehi 3897 19 RR RR NNP cord-335975-m6lkrehi 3897 20 Vt Vt NNP cord-335975-m6lkrehi 3897 21 , , , cord-335975-m6lkrehi 3897 22 vital vital JJ cord-335975-m6lkrehi 3897 23 capacity capacity NN cord-335975-m6lkrehi 3897 24 or or CC cord-335975-m6lkrehi 3897 25 inspiratory inspiratory JJ cord-335975-m6lkrehi 3897 26 pressure pressure NN cord-335975-m6lkrehi 3897 27 . . . cord-335975-m6lkrehi 3898 1 8.1 8.1 CD cord-335975-m6lkrehi 3898 2 % % NN cord-335975-m6lkrehi 3898 3 of of IN cord-335975-m6lkrehi 3898 4 patients patient NNS cord-335975-m6lkrehi 3898 5 had have VBD cord-335975-m6lkrehi 3898 6 otolaryngologist otolaryngologist NN cord-335975-m6lkrehi 3898 7 follow follow NN cord-335975-m6lkrehi 3898 8 - - HYPH cord-335975-m6lkrehi 3898 9 up up NN cord-335975-m6lkrehi 3898 10 . . . cord-335975-m6lkrehi 3899 1 The the DT cord-335975-m6lkrehi 3899 2 overall overall JJ cord-335975-m6lkrehi 3899 3 mortality mortality NN cord-335975-m6lkrehi 3899 4 of of IN cord-335975-m6lkrehi 3899 5 the the DT cord-335975-m6lkrehi 3899 6 studied study VBN cord-335975-m6lkrehi 3899 7 population population NN cord-335975-m6lkrehi 3899 8 was be VBD cord-335975-m6lkrehi 3899 9 30.1 30.1 CD cord-335975-m6lkrehi 3899 10 % % NN cord-335975-m6lkrehi 3899 11 including include VBG cord-335975-m6lkrehi 3899 12 mortality mortality NN cord-335975-m6lkrehi 3899 13 related relate VBN cord-335975-m6lkrehi 3899 14 to to IN cord-335975-m6lkrehi 3899 15 tracheostomy tracheostomy NN cord-335975-m6lkrehi 3899 16 in in IN cord-335975-m6lkrehi 3899 17 2 2 CD cord-335975-m6lkrehi 3899 18 patients patient NNS cord-335975-m6lkrehi 3899 19 . . . cord-335975-m6lkrehi 3900 1 The the DT cord-335975-m6lkrehi 3900 2 tracheostomy tracheostomy NN cord-335975-m6lkrehi 3900 3 for for IN cord-335975-m6lkrehi 3900 4 extended extended JJ cord-335975-m6lkrehi 3900 5 mechanical mechanical JJ cord-335975-m6lkrehi 3900 6 ventilation ventilation NN cord-335975-m6lkrehi 3900 7 was be VBD cord-335975-m6lkrehi 3900 8 significantly significantly RB cord-335975-m6lkrehi 3900 9 associated associate VBN cord-335975-m6lkrehi 3900 10 with with IN cord-335975-m6lkrehi 3900 11 an an DT cord-335975-m6lkrehi 3900 12 increase increase NN cord-335975-m6lkrehi 3900 13 of of IN cord-335975-m6lkrehi 3900 14 mechanical mechanical JJ cord-335975-m6lkrehi 3900 15 ventilation ventilation NN cord-335975-m6lkrehi 3900 16 duration duration NN cord-335975-m6lkrehi 3900 17 before before IN cord-335975-m6lkrehi 3900 18 tracheostomy tracheostomy NN cord-335975-m6lkrehi 3900 19 ( ( -LRB- cord-335975-m6lkrehi 3900 20 p p NN cord-335975-m6lkrehi 3900 21 < < XX cord-335975-m6lkrehi 3900 22 0.0001 0.0001 CD cord-335975-m6lkrehi 3900 23 ) ) -RRB- cord-335975-m6lkrehi 3900 24 , , , cord-335975-m6lkrehi 3900 25 duration duration NN cord-335975-m6lkrehi 3900 26 of of IN cord-335975-m6lkrehi 3900 27 mechanical mechanical JJ cord-335975-m6lkrehi 3900 28 ventilation ventilation NN cord-335975-m6lkrehi 3900 29 ( ( -LRB- cord-335975-m6lkrehi 3900 30 p p NN cord-335975-m6lkrehi 3900 31 < < XX cord-335975-m6lkrehi 3900 32 0.0001 0.0001 CD cord-335975-m6lkrehi 3900 33 ) ) -RRB- cord-335975-m6lkrehi 3900 34 , , , cord-335975-m6lkrehi 3900 35 length length NN cord-335975-m6lkrehi 3900 36 of of IN cord-335975-m6lkrehi 3900 37 stay stay NN cord-335975-m6lkrehi 3900 38 in in IN cord-335975-m6lkrehi 3900 39 intensive intensive JJ cord-335975-m6lkrehi 3900 40 care care NN cord-335975-m6lkrehi 3900 41 unit unit NN cord-335975-m6lkrehi 3900 42 ( ( -LRB- cord-335975-m6lkrehi 3900 43 p p NN cord-335975-m6lkrehi 3900 44 < < XX cord-335975-m6lkrehi 3900 45 0.0001 0.0001 CD cord-335975-m6lkrehi 3900 46 ) ) -RRB- cord-335975-m6lkrehi 3900 47 and and CC cord-335975-m6lkrehi 3900 48 mortality mortality NN cord-335975-m6lkrehi 3900 49 rate rate NN cord-335975-m6lkrehi 3900 50 ( ( -LRB- cord-335975-m6lkrehi 3900 51 p p NN cord-335975-m6lkrehi 3900 52 = = SYM cord-335975-m6lkrehi 3900 53 0.0003 0.0003 CD cord-335975-m6lkrehi 3900 54 ) ) -RRB- cord-335975-m6lkrehi 3900 55 . . . cord-335975-m6lkrehi 3901 1 Introduction introduction NN cord-335975-m6lkrehi 3901 2 : : : cord-335975-m6lkrehi 3902 1 Acute acute JJ cord-335975-m6lkrehi 3902 2 renal renal JJ cord-335975-m6lkrehi 3902 3 failure failure NN cord-335975-m6lkrehi 3902 4 complicating complicate VBG cord-335975-m6lkrehi 3902 5 surgery surgery NN cord-335975-m6lkrehi 3902 6 has have VBZ cord-335975-m6lkrehi 3902 7 a a DT cord-335975-m6lkrehi 3902 8 particularly particularly RB cord-335975-m6lkrehi 3902 9 harmful harmful JJ cord-335975-m6lkrehi 3902 10 prognosis prognosis NN cord-335975-m6lkrehi 3902 11 , , , cord-335975-m6lkrehi 3902 12 with with IN cord-335975-m6lkrehi 3902 13 a a DT cord-335975-m6lkrehi 3902 14 mortality mortality NN cord-335975-m6lkrehi 3902 15 of of IN cord-335975-m6lkrehi 3902 16 40 40 CD cord-335975-m6lkrehi 3902 17 % % NN cord-335975-m6lkrehi 3902 18 to to TO cord-335975-m6lkrehi 3902 19 90 90 CD cord-335975-m6lkrehi 3902 20 % % NN cord-335975-m6lkrehi 3902 21 . . . cord-335975-m6lkrehi 3903 1 This this DT cord-335975-m6lkrehi 3903 2 high high JJ cord-335975-m6lkrehi 3903 3 mortality mortality NN cord-335975-m6lkrehi 3903 4 rate rate NN cord-335975-m6lkrehi 3903 5 is be VBZ cord-335975-m6lkrehi 3903 6 attributed attribute VBN cord-335975-m6lkrehi 3903 7 to to IN cord-335975-m6lkrehi 3903 8 patient patient NN cord-335975-m6lkrehi 3903 9 - - HYPH cord-335975-m6lkrehi 3903 10 related relate VBN cord-335975-m6lkrehi 3903 11 factors factor NNS cord-335975-m6lkrehi 3903 12 , , , cord-335975-m6lkrehi 3903 13 the the DT cord-335975-m6lkrehi 3903 14 severity severity NN cord-335975-m6lkrehi 3903 15 of of IN cord-335975-m6lkrehi 3903 16 the the DT cord-335975-m6lkrehi 3903 17 disease disease NN cord-335975-m6lkrehi 3903 18 and and CC cord-335975-m6lkrehi 3903 19 the the DT cord-335975-m6lkrehi 3903 20 type type NN cord-335975-m6lkrehi 3903 21 of of IN cord-335975-m6lkrehi 3903 22 surgery surgery NN cord-335975-m6lkrehi 3903 23 , , , cord-335975-m6lkrehi 3903 24 but but CC cord-335975-m6lkrehi 3903 25 not not RB cord-335975-m6lkrehi 3903 26 to to IN cord-335975-m6lkrehi 3903 27 the the DT cord-335975-m6lkrehi 3903 28 acute acute JJ cord-335975-m6lkrehi 3903 29 renal renal JJ cord-335975-m6lkrehi 3903 30 failure failure NN cord-335975-m6lkrehi 3903 31 itself -PRON- PRP cord-335975-m6lkrehi 3903 32 . . . cord-335975-m6lkrehi 3904 1 The the DT cord-335975-m6lkrehi 3904 2 aim aim NN cord-335975-m6lkrehi 3904 3 of of IN cord-335975-m6lkrehi 3904 4 our -PRON- PRP$ cord-335975-m6lkrehi 3904 5 study study NN cord-335975-m6lkrehi 3904 6 is be VBZ cord-335975-m6lkrehi 3904 7 to to TO cord-335975-m6lkrehi 3904 8 elucidate elucidate VB cord-335975-m6lkrehi 3904 9 the the DT cord-335975-m6lkrehi 3904 10 prognostic prognostic JJ cord-335975-m6lkrehi 3904 11 factors factor NNS cord-335975-m6lkrehi 3904 12 of of IN cord-335975-m6lkrehi 3904 13 acute acute JJ cord-335975-m6lkrehi 3904 14 renal renal JJ cord-335975-m6lkrehi 3904 15 failure failure NN cord-335975-m6lkrehi 3904 16 in in IN cord-335975-m6lkrehi 3904 17 the the DT cord-335975-m6lkrehi 3904 18 postoperative postoperative JJ cord-335975-m6lkrehi 3904 19 sepsis sepsis NN cord-335975-m6lkrehi 3904 20 in in IN cord-335975-m6lkrehi 3904 21 a a DT cord-335975-m6lkrehi 3904 22 series series NN cord-335975-m6lkrehi 3904 23 of of IN cord-335975-m6lkrehi 3904 24 100 100 CD cord-335975-m6lkrehi 3904 25 patients patient NNS cord-335975-m6lkrehi 3904 26 . . . cord-335975-m6lkrehi 3905 1 It -PRON- PRP cord-335975-m6lkrehi 3905 2 is be VBZ cord-335975-m6lkrehi 3905 3 a a DT cord-335975-m6lkrehi 3905 4 retrospective retrospective JJ cord-335975-m6lkrehi 3905 5 analytical analytical JJ cord-335975-m6lkrehi 3905 6 descriptive descriptive JJ cord-335975-m6lkrehi 3905 7 study study NN cord-335975-m6lkrehi 3905 8 spread spread VBD cord-335975-m6lkrehi 3905 9 over over IN cord-335975-m6lkrehi 3905 10 a a DT cord-335975-m6lkrehi 3905 11 period period NN cord-335975-m6lkrehi 3905 12 of of IN cord-335975-m6lkrehi 3905 13 4 4 CD cord-335975-m6lkrehi 3905 14 years year NNS cord-335975-m6lkrehi 3905 15 ( ( -LRB- cord-335975-m6lkrehi 3905 16 from from IN cord-335975-m6lkrehi 3905 17 January January NNP cord-335975-m6lkrehi 3905 18 2013 2013 CD cord-335975-m6lkrehi 3905 19 to to IN cord-335975-m6lkrehi 3905 20 December December NNP cord-335975-m6lkrehi 3905 21 2016 2016 CD cord-335975-m6lkrehi 3905 22 ) ) -RRB- cord-335975-m6lkrehi 3905 23 , , , cord-335975-m6lkrehi 3905 24 100 100 CD cord-335975-m6lkrehi 3905 25 observations observation NNS cord-335975-m6lkrehi 3905 26 of of IN cord-335975-m6lkrehi 3905 27 postoperative postoperative JJ cord-335975-m6lkrehi 3905 28 peritonitis peritonitis NN cord-335975-m6lkrehi 3905 29 were be VBD cord-335975-m6lkrehi 3905 30 collected collect VBN cord-335975-m6lkrehi 3905 31 in in IN cord-335975-m6lkrehi 3905 32 the the DT cord-335975-m6lkrehi 3905 33 service service NN cord-335975-m6lkrehi 3905 34 of of IN cord-335975-m6lkrehi 3905 35 resuscitation resuscitation NN cord-335975-m6lkrehi 3905 36 of of IN cord-335975-m6lkrehi 3905 37 surgical surgical JJ cord-335975-m6lkrehi 3905 38 emergencies emergency NNS cord-335975-m6lkrehi 3905 39 of of IN cord-335975-m6lkrehi 3905 40 CHU CHU NNP cord-335975-m6lkrehi 3905 41 Ibn Ibn NNP cord-335975-m6lkrehi 3905 42 Rochdof Rochdof NNP cord-335975-m6lkrehi 3905 43 Casablanca Casablanca NNP cord-335975-m6lkrehi 3905 44 . . . cord-335975-m6lkrehi 3906 1 The the DT cord-335975-m6lkrehi 3906 2 statistical statistical JJ cord-335975-m6lkrehi 3906 3 analysis analysis NN cord-335975-m6lkrehi 3906 4 was be VBD cord-335975-m6lkrehi 3906 5 carried carry VBN cord-335975-m6lkrehi 3906 6 out out RP cord-335975-m6lkrehi 3906 7 using use VBG cord-335975-m6lkrehi 3906 8 the the DT cord-335975-m6lkrehi 3906 9 SPSS SPSS NNP cord-335975-m6lkrehi 3906 10 20 20 CD cord-335975-m6lkrehi 3906 11 software software NN cord-335975-m6lkrehi 3906 12 . . . cord-335975-m6lkrehi 3907 1 The the DT cord-335975-m6lkrehi 3907 2 results result NNS cord-335975-m6lkrehi 3907 3 are be VBP cord-335975-m6lkrehi 3907 4 expressed express VBN cord-335975-m6lkrehi 3907 5 with with IN cord-335975-m6lkrehi 3907 6 OR OR NNP cord-335975-m6lkrehi 3907 7 and and CC cord-335975-m6lkrehi 3907 8 95 95 CD cord-335975-m6lkrehi 3907 9 % % NN cord-335975-m6lkrehi 3907 10 confidence confidence NN cord-335975-m6lkrehi 3907 11 intervals interval NNS cord-335975-m6lkrehi 3907 12 ( ( -LRB- cord-335975-m6lkrehi 3907 13 CI CI NNP cord-335975-m6lkrehi 3907 14 at at IN cord-335975-m6lkrehi 3907 15 95 95 CD cord-335975-m6lkrehi 3907 16 % % NN cord-335975-m6lkrehi 3907 17 ) ) -RRB- cord-335975-m6lkrehi 3907 18 . . . cord-335975-m6lkrehi 3908 1 The the DT cord-335975-m6lkrehi 3908 2 results result NNS cord-335975-m6lkrehi 3908 3 were be VBD cord-335975-m6lkrehi 3908 4 considered consider VBN cord-335975-m6lkrehi 3908 5 significant significant JJ cord-335975-m6lkrehi 3908 6 when when WRB cord-335975-m6lkrehi 3908 7 P p NN cord-335975-m6lkrehi 3908 8 is be VBZ cord-335975-m6lkrehi 3908 9 < < XX cord-335975-m6lkrehi 3908 10 0.05 0.05 CD cord-335975-m6lkrehi 3908 11 . . . cord-335975-m6lkrehi 3909 1 The the DT cord-335975-m6lkrehi 3909 2 mean mean JJ cord-335975-m6lkrehi 3909 3 age age NN cord-335975-m6lkrehi 3909 4 of of IN cord-335975-m6lkrehi 3909 5 the the DT cord-335975-m6lkrehi 3909 6 patients patient NNS cord-335975-m6lkrehi 3909 7 was be VBD cord-335975-m6lkrehi 3909 8 46 46 CD cord-335975-m6lkrehi 3909 9 ± ± CD cord-335975-m6lkrehi 3909 10 14 14 CD cord-335975-m6lkrehi 3909 11 years year NNS cord-335975-m6lkrehi 3909 12 with with IN cord-335975-m6lkrehi 3909 13 a a DT cord-335975-m6lkrehi 3909 14 sex sex NN cord-335975-m6lkrehi 3909 15 ratio ratio NN cord-335975-m6lkrehi 3909 16 of of IN cord-335975-m6lkrehi 3909 17 1.94 1.94 CD cord-335975-m6lkrehi 3909 18 ( ( -LRB- cord-335975-m6lkrehi 3909 19 66 66 CD cord-335975-m6lkrehi 3909 20 M m CD cord-335975-m6lkrehi 3909 21 34 34 CD cord-335975-m6lkrehi 3909 22 ) ) -RRB- cord-335975-m6lkrehi 3909 23 . . . cord-335975-m6lkrehi 3910 1 Renal renal JJ cord-335975-m6lkrehi 3910 2 failure failure NN cord-335975-m6lkrehi 3910 3 was be VBD cord-335975-m6lkrehi 3910 4 the the DT cord-335975-m6lkrehi 3910 5 most most RBS cord-335975-m6lkrehi 3910 6 frequent frequent JJ cord-335975-m6lkrehi 3910 7 failure failure NN cord-335975-m6lkrehi 3910 8 after after IN cord-335975-m6lkrehi 3910 9 hemodynamic hemodynamic JJ cord-335975-m6lkrehi 3910 10 failure failure NN cord-335975-m6lkrehi 3910 11 , , , cord-335975-m6lkrehi 3910 12 11 11 CD cord-335975-m6lkrehi 3910 13 patients patient NNS cord-335975-m6lkrehi 3910 14 were be VBD cord-335975-m6lkrehi 3910 15 oliguric oliguric JJ cord-335975-m6lkrehi 3910 16 , , , cord-335975-m6lkrehi 3910 17 4 4 CD cord-335975-m6lkrehi 3910 18 anuriques anurique NNS cord-335975-m6lkrehi 3910 19 and and CC cord-335975-m6lkrehi 3910 20 37 37 CD cord-335975-m6lkrehi 3910 21 patients patient NNS cord-335975-m6lkrehi 3910 22 had have VBD cord-335975-m6lkrehi 3910 23 a a DT cord-335975-m6lkrehi 3910 24 preserved preserve VBN cord-335975-m6lkrehi 3910 25 diuresis diuresis NN cord-335975-m6lkrehi 3910 26 , , , cord-335975-m6lkrehi 3910 27 patients patient NNS cord-335975-m6lkrehi 3910 28 were be VBD cord-335975-m6lkrehi 3910 29 divided divide VBN cord-335975-m6lkrehi 3910 30 according accord VBG cord-335975-m6lkrehi 3910 31 to to IN cord-335975-m6lkrehi 3910 32 the the DT cord-335975-m6lkrehi 3910 33 RIFLE RIFLE NNP cord-335975-m6lkrehi 3910 34 ( ( -LRB- cord-335975-m6lkrehi 3910 35 R r NN cord-335975-m6lkrehi 3910 36 49 49 CD cord-335975-m6lkrehi 3910 37 % % NN cord-335975-m6lkrehi 3910 38 , , , cord-335975-m6lkrehi 3910 39 I -PRON- PRP cord-335975-m6lkrehi 3910 40 26 26 CD cord-335975-m6lkrehi 3910 41 % % NN cord-335975-m6lkrehi 3910 42 , , , cord-335975-m6lkrehi 3910 43 F F NNP cord-335975-m6lkrehi 3910 44 25 25 CD cord-335975-m6lkrehi 3910 45 % % NN cord-335975-m6lkrehi 3910 46 ) ) -RRB- cord-335975-m6lkrehi 3910 47 and and CC cord-335975-m6lkrehi 3910 48 AKIN akin NN cord-335975-m6lkrehi 3911 1 ( ( -LRB- cord-335975-m6lkrehi 3911 2 I i NN cord-335975-m6lkrehi 3911 3 49 49 CD cord-335975-m6lkrehi 3911 4 % % NN cord-335975-m6lkrehi 3911 5 , , , cord-335975-m6lkrehi 3911 6 II II NNP cord-335975-m6lkrehi 3911 7 26 26 CD cord-335975-m6lkrehi 3911 8 % % NN cord-335975-m6lkrehi 3911 9 , , , cord-335975-m6lkrehi 3911 10 III iii CD cord-335975-m6lkrehi 3911 11 25 25 CD cord-335975-m6lkrehi 3911 12 % % NN cord-335975-m6lkrehi 3911 13 ) ) -RRB- cord-335975-m6lkrehi 3911 14 . . . cord-335975-m6lkrehi 3912 1 The the DT cord-335975-m6lkrehi 3912 2 predictive predictive JJ cord-335975-m6lkrehi 3912 3 factors factor NNS cord-335975-m6lkrehi 3912 4 of of IN cord-335975-m6lkrehi 3912 5 acute acute JJ cord-335975-m6lkrehi 3912 6 renal renal JJ cord-335975-m6lkrehi 3912 7 failure failure NN cord-335975-m6lkrehi 3912 8 ARI ARI NNP cord-335975-m6lkrehi 3912 9 were be VBD cord-335975-m6lkrehi 3912 10 studied study VBN cord-335975-m6lkrehi 3912 11 in in IN cord-335975-m6lkrehi 3912 12 univariate univariate JJ cord-335975-m6lkrehi 3912 13 and and CC cord-335975-m6lkrehi 3912 14 multivariate multivariate JJ cord-335975-m6lkrehi 3912 15 analysis analysis NN cord-335975-m6lkrehi 3912 16 , , , cord-335975-m6lkrehi 3912 17 2 2 CD cord-335975-m6lkrehi 3912 18 factors factor NNS cord-335975-m6lkrehi 3912 19 were be VBD cord-335975-m6lkrehi 3912 20 retained retain VBN cord-335975-m6lkrehi 3912 21 including include VBG cord-335975-m6lkrehi 3912 22 catecholamines catecholamine NNS cord-335975-m6lkrehi 3912 23 - - HYPH cord-335975-m6lkrehi 3912 24 OR or NN cord-335975-m6lkrehi 3912 25 3.362 3.362 CD cord-335975-m6lkrehi 3912 26 + + SYM cord-335975-m6lkrehi 3912 27 CI ci NN cord-335975-m6lkrehi 3912 28 at at IN cord-335975-m6lkrehi 3912 29 95 95 CD cord-335975-m6lkrehi 3912 30 % % NN cord-335975-m6lkrehi 3912 31 between between IN cord-335975-m6lkrehi 3912 32 1.202 1.202 CD cord-335975-m6lkrehi 3912 33 and and CC cord-335975-m6lkrehi 3912 34 3.397 3.397 CD cord-335975-m6lkrehi 3912 35 + + SYM cord-335975-m6lkrehi 3912 36 p p NN cord-335975-m6lkrehi 3912 37 = = SYM cord-335975-m6lkrehi 3912 38 0.021 0.021 CD cord-335975-m6lkrehi 3912 39 + + CC cord-335975-m6lkrehi 3913 1 the the DT cord-335975-m6lkrehi 3913 2 surgical surgical JJ cord-335975-m6lkrehi 3913 3 site site NN cord-335975-m6lkrehi 3913 4 - - : cord-335975-m6lkrehi 3913 5 OR or CC cord-335975-m6lkrehi 3913 6 0.367 0.367 CD cord-335975-m6lkrehi 3914 1 + + CC cord-335975-m6lkrehi 3915 1 CI CI NNP cord-335975-m6lkrehi 3915 2 at at IN cord-335975-m6lkrehi 3915 3 95 95 CD cord-335975-m6lkrehi 3915 4 % % NN cord-335975-m6lkrehi 3915 5 between between IN cord-335975-m6lkrehi 3915 6 0.145 0.145 CD cord-335975-m6lkrehi 3915 7 and and CC cord-335975-m6lkrehi 3915 8 0.929 0.929 CD cord-335975-m6lkrehi 3916 1 + + CC cord-335975-m6lkrehi 3916 2 p p NN cord-335975-m6lkrehi 3916 3 = = SYM cord-335975-m6lkrehi 3916 4 0.034 0.034 CD cord-335975-m6lkrehi 3916 5 . . . cord-335975-m6lkrehi 3917 1 Conclusion conclusion NN cord-335975-m6lkrehi 3917 2 : : : cord-335975-m6lkrehi 3918 1 Acute acute JJ cord-335975-m6lkrehi 3918 2 renal renal JJ cord-335975-m6lkrehi 3918 3 failure failure NN cord-335975-m6lkrehi 3918 4 is be VBZ cord-335975-m6lkrehi 3918 5 an an DT cord-335975-m6lkrehi 3918 6 independent independent JJ cord-335975-m6lkrehi 3918 7 factor factor NN cord-335975-m6lkrehi 3918 8 of of IN cord-335975-m6lkrehi 3918 9 mortality mortality NN cord-335975-m6lkrehi 3918 10 in in IN cord-335975-m6lkrehi 3918 11 the the DT cord-335975-m6lkrehi 3918 12 post post JJ cord-335975-m6lkrehi 3918 13 - - JJ cord-335975-m6lkrehi 3918 14 operative operative JJ cord-335975-m6lkrehi 3918 15 sepsis sepsis NN cord-335975-m6lkrehi 3918 16 , , , cord-335975-m6lkrehi 3918 17 but but CC cord-335975-m6lkrehi 3918 18 remains remain VBZ cord-335975-m6lkrehi 3918 19 that that IN cord-335975-m6lkrehi 3918 20 its -PRON- PRP$ cord-335975-m6lkrehi 3918 21 presence presence NN cord-335975-m6lkrehi 3918 22 is be VBZ cord-335975-m6lkrehi 3918 23 a a DT cord-335975-m6lkrehi 3918 24 pejorative pejorative JJ cord-335975-m6lkrehi 3918 25 prognostic prognostic JJ cord-335975-m6lkrehi 3918 26 factor factor NN cord-335975-m6lkrehi 3918 27 . . . cord-335975-m6lkrehi 3918 28 _SP cord-335975-m6lkrehi 3919 1 This this DT cord-335975-m6lkrehi 3919 2 was be VBD cord-335975-m6lkrehi 3919 3 a a DT cord-335975-m6lkrehi 3919 4 retrospective retrospective JJ cord-335975-m6lkrehi 3919 5 study study NN cord-335975-m6lkrehi 3919 6 performed perform VBN cord-335975-m6lkrehi 3919 7 in in IN cord-335975-m6lkrehi 3919 8 a a DT cord-335975-m6lkrehi 3919 9 large large JJ cord-335975-m6lkrehi 3919 10 University University NNP cord-335975-m6lkrehi 3919 11 Hospital Hospital NNP cord-335975-m6lkrehi 3919 12 . . . cord-335975-m6lkrehi 3920 1 All all DT cord-335975-m6lkrehi 3920 2 patients patient NNS cord-335975-m6lkrehi 3920 3 receiving receive VBG cord-335975-m6lkrehi 3920 4 the the DT cord-335975-m6lkrehi 3920 5 molecule molecule NN cord-335975-m6lkrehi 3920 6 were be VBD cord-335975-m6lkrehi 3920 7 included include VBN cord-335975-m6lkrehi 3920 8 in in IN cord-335975-m6lkrehi 3920 9 the the DT cord-335975-m6lkrehi 3920 10 analysis analysis NN cord-335975-m6lkrehi 3920 11 . . . cord-335975-m6lkrehi 3921 1 Indication indication NN cord-335975-m6lkrehi 3921 2 for for IN cord-335975-m6lkrehi 3921 3 sodium sodium NN cord-335975-m6lkrehi 3921 4 lactate lactate NN cord-335975-m6lkrehi 3921 5 , , , cord-335975-m6lkrehi 3921 6 dose dose NN cord-335975-m6lkrehi 3921 7 , , , cord-335975-m6lkrehi 3921 8 and and CC cord-335975-m6lkrehi 3921 9 modality modality NN cord-335975-m6lkrehi 3921 10 of of IN cord-335975-m6lkrehi 3921 11 administration administration NN cord-335975-m6lkrehi 3921 12 were be VBD cord-335975-m6lkrehi 3921 13 collected collect VBN cord-335975-m6lkrehi 3921 14 . . . cord-335975-m6lkrehi 3922 1 We -PRON- PRP cord-335975-m6lkrehi 3922 2 also also RB cord-335975-m6lkrehi 3922 3 collected collect VBD cord-335975-m6lkrehi 3922 4 clinical clinical JJ cord-335975-m6lkrehi 3922 5 and and CC cord-335975-m6lkrehi 3922 6 biological biological JJ cord-335975-m6lkrehi 3922 7 variables variable NNS cord-335975-m6lkrehi 3922 8 before before IN cord-335975-m6lkrehi 3922 9 sodium sodium NN cord-335975-m6lkrehi 3922 10 lactate lactate NN cord-335975-m6lkrehi 3922 11 infusion infusion NN cord-335975-m6lkrehi 3922 12 , , , cord-335975-m6lkrehi 3922 13 after after IN cord-335975-m6lkrehi 3922 14 6 6 CD cord-335975-m6lkrehi 3922 15 h h NN cord-335975-m6lkrehi 3922 16 ( ( -LRB- cord-335975-m6lkrehi 3922 17 H6 H6 NNP cord-335975-m6lkrehi 3922 18 ) ) -RRB- cord-335975-m6lkrehi 3922 19 , , , cord-335975-m6lkrehi 3922 20 and and CC cord-335975-m6lkrehi 3922 21 after after IN cord-335975-m6lkrehi 3922 22 24 24 CD cord-335975-m6lkrehi 3922 23 h h NN cord-335975-m6lkrehi 3922 24 ( ( -LRB- cord-335975-m6lkrehi 3922 25 H24 H24 NNP cord-335975-m6lkrehi 3922 26 ) ) -RRB- cord-335975-m6lkrehi 3922 27 . . . cord-335975-m6lkrehi 3923 1 An an DT cord-335975-m6lkrehi 3923 2 analysis analysis NN cord-335975-m6lkrehi 3923 3 of of IN cord-335975-m6lkrehi 3923 4 the the DT cord-335975-m6lkrehi 3923 5 evolution evolution NN cord-335975-m6lkrehi 3923 6 of of IN cord-335975-m6lkrehi 3923 7 these these DT cord-335975-m6lkrehi 3923 8 variables variable NNS cord-335975-m6lkrehi 3923 9 at at IN cord-335975-m6lkrehi 3923 10 H6 H6 NNP cord-335975-m6lkrehi 3923 11 and and CC cord-335975-m6lkrehi 3923 12 H24 H24 NNP cord-335975-m6lkrehi 3923 13 was be VBD cord-335975-m6lkrehi 3923 14 performed perform VBN cord-335975-m6lkrehi 3923 15 . . . cord-335975-m6lkrehi 3924 1 Results result NNS cord-335975-m6lkrehi 3924 2 : : : cord-335975-m6lkrehi 3925 1 Between between IN cord-335975-m6lkrehi 3925 2 January January NNP cord-335975-m6lkrehi 3925 3 2016 2016 CD cord-335975-m6lkrehi 3925 4 and and CC cord-335975-m6lkrehi 3925 5 May May NNP cord-335975-m6lkrehi 3925 6 2017 2017 CD cord-335975-m6lkrehi 3925 7 , , , cord-335975-m6lkrehi 3925 8 104 104 CD cord-335975-m6lkrehi 3925 9 patients patient NNS cord-335975-m6lkrehi 3925 10 , , , cord-335975-m6lkrehi 3925 11 aged aged JJ cord-335975-m6lkrehi 3925 12 64 64 CD cord-335975-m6lkrehi 3925 13 years year NNS cord-335975-m6lkrehi 3925 14 , , , cord-335975-m6lkrehi 3925 15 66 66 CD cord-335975-m6lkrehi 3925 16 % % NN cord-335975-m6lkrehi 3925 17 males male NNS cord-335975-m6lkrehi 3925 18 , , , cord-335975-m6lkrehi 3925 19 SOFA sofa NN cord-335975-m6lkrehi 3925 20 score score NN cord-335975-m6lkrehi 3925 21 9 9 CD cord-335975-m6lkrehi 3925 22 [ [ -LRB- cord-335975-m6lkrehi 3925 23 7 7 CD cord-335975-m6lkrehi 3925 24 - - SYM cord-335975-m6lkrehi 3925 25 12 12 CD cord-335975-m6lkrehi 3925 26 ] ] -RRB- cord-335975-m6lkrehi 3925 27 , , , cord-335975-m6lkrehi 3925 28 received receive VBD cord-335975-m6lkrehi 3925 29 an an DT cord-335975-m6lkrehi 3925 30 infusion infusion NN cord-335975-m6lkrehi 3925 31 of of IN cord-335975-m6lkrehi 3925 32 molar molar JJ cord-335975-m6lkrehi 3925 33 sodium sodium NN cord-335975-m6lkrehi 3925 34 lactate lactate NN cord-335975-m6lkrehi 3925 35 ( ( -LRB- cord-335975-m6lkrehi 3925 36 250 250 CD cord-335975-m6lkrehi 3925 37 ml ml NN cord-335975-m6lkrehi 3925 38 ) ) -RRB- cord-335975-m6lkrehi 3925 39 . . . cord-335975-m6lkrehi 3926 1 Main main JJ cord-335975-m6lkrehi 3926 2 indications indication NNS cord-335975-m6lkrehi 3926 3 for for IN cord-335975-m6lkrehi 3926 4 sodium sodium NN cord-335975-m6lkrehi 3926 5 lactate lactate NN cord-335975-m6lkrehi 3926 6 were be VBD cord-335975-m6lkrehi 3926 7 hyperchloremic hyperchloremic JJ cord-335975-m6lkrehi 3926 8 metabolic metabolic JJ cord-335975-m6lkrehi 3926 9 acidosis acidosis NN cord-335975-m6lkrehi 3926 10 ( ( -LRB- cord-335975-m6lkrehi 3926 11 68 68 CD cord-335975-m6lkrehi 3926 12 % % NN cord-335975-m6lkrehi 3926 13 ) ) -RRB- cord-335975-m6lkrehi 3926 14 , , , cord-335975-m6lkrehi 3926 15 vascular vascular JJ cord-335975-m6lkrehi 3926 16 filling filling NN cord-335975-m6lkrehi 3926 17 ( ( -LRB- cord-335975-m6lkrehi 3926 18 15 15 CD cord-335975-m6lkrehi 3926 19 % % NN cord-335975-m6lkrehi 3926 20 ) ) -RRB- cord-335975-m6lkrehi 3926 21 , , , cord-335975-m6lkrehi 3926 22 mixed mixed JJ cord-335975-m6lkrehi 3926 23 acidosis acidosis NN cord-335975-m6lkrehi 3926 24 ( ( -LRB- cord-335975-m6lkrehi 3926 25 12 12 CD cord-335975-m6lkrehi 3926 26 % % NN cord-335975-m6lkrehi 3926 27 ) ) -RRB- cord-335975-m6lkrehi 3926 28 , , , cord-335975-m6lkrehi 3926 29 and and CC cord-335975-m6lkrehi 3926 30 intracranial intracranial JJ cord-335975-m6lkrehi 3926 31 hypertension hypertension NN cord-335975-m6lkrehi 3926 32 ( ( -LRB- cord-335975-m6lkrehi 3926 33 5 5 CD cord-335975-m6lkrehi 3926 34 % % NN cord-335975-m6lkrehi 3926 35 ) ) -RRB- cord-335975-m6lkrehi 3926 36 . . . cord-335975-m6lkrehi 3927 1 84 84 CD cord-335975-m6lkrehi 3927 2 % % NN cord-335975-m6lkrehi 3927 3 of of IN cord-335975-m6lkrehi 3927 4 the the DT cord-335975-m6lkrehi 3927 5 patients patient NNS cord-335975-m6lkrehi 3927 6 presented present VBN cord-335975-m6lkrehi 3927 7 with with IN cord-335975-m6lkrehi 3927 8 a a DT cord-335975-m6lkrehi 3927 9 chloride chloride NN cord-335975-m6lkrehi 3927 10 sodium sodium NN cord-335975-m6lkrehi 3927 11 ratio ratio NN cord-335975-m6lkrehi 3927 12 > > XX cord-335975-m6lkrehi 3927 13 = = SYM cord-335975-m6lkrehi 3927 14 0.76 0.76 CD cord-335975-m6lkrehi 3927 15 at at IN cord-335975-m6lkrehi 3927 16 basal basal NN cord-335975-m6lkrehi 3927 17 time time NN cord-335975-m6lkrehi 3927 18 . . . cord-335975-m6lkrehi 3928 1 Sodium sodium NN cord-335975-m6lkrehi 3928 2 lactate lactate NN cord-335975-m6lkrehi 3928 3 was be VBD cord-335975-m6lkrehi 3928 4 associated associate VBN cord-335975-m6lkrehi 3928 5 with with IN cord-335975-m6lkrehi 3928 6 a a DT cord-335975-m6lkrehi 3928 7 significant significant JJ cord-335975-m6lkrehi 3928 8 increase increase NN cord-335975-m6lkrehi 3928 9 of of IN cord-335975-m6lkrehi 3928 10 mean mean JJ cord-335975-m6lkrehi 3928 11 arterial arterial JJ cord-335975-m6lkrehi 3928 12 pressure pressure NN cord-335975-m6lkrehi 3928 13 at at IN cord-335975-m6lkrehi 3928 14 H6 H6 NNP cord-335975-m6lkrehi 3928 15 ( ( -LRB- cord-335975-m6lkrehi 3928 16 p p NN cord-335975-m6lkrehi 3928 17 = = SYM cord-335975-m6lkrehi 3928 18 0.009 0.009 CD cord-335975-m6lkrehi 3928 19 ) ) -RRB- cord-335975-m6lkrehi 3928 20 and and CC cord-335975-m6lkrehi 3928 21 H24 H24 NNP cord-335975-m6lkrehi 3928 22 ( ( -LRB- cord-335975-m6lkrehi 3928 23 p p NN cord-335975-m6lkrehi 3928 24 = = SYM cord-335975-m6lkrehi 3928 25 0.003 0.003 CD cord-335975-m6lkrehi 3928 26 ) ) -RRB- cord-335975-m6lkrehi 3928 27 , , , cord-335975-m6lkrehi 3928 28 a a DT cord-335975-m6lkrehi 3928 29 decrease decrease NN cord-335975-m6lkrehi 3928 30 of of IN cord-335975-m6lkrehi 3928 31 catecholamine catecholamine NN cord-335975-m6lkrehi 3928 32 dose dose NN cord-335975-m6lkrehi 3928 33 ( ( -LRB- cord-335975-m6lkrehi 3928 34 p p NN cord-335975-m6lkrehi 3928 35 = = SYM cord-335975-m6lkrehi 3928 36 0.002 0.002 CD cord-335975-m6lkrehi 3928 37 ) ) -RRB- cord-335975-m6lkrehi 3928 38 and and CC cord-335975-m6lkrehi 3928 39 heart heart NN cord-335975-m6lkrehi 3928 40 rate rate NN cord-335975-m6lkrehi 3928 41 ( ( -LRB- cord-335975-m6lkrehi 3928 42 p p NN cord-335975-m6lkrehi 3928 43 = = SYM cord-335975-m6lkrehi 3928 44 0.05 0.05 CD cord-335975-m6lkrehi 3928 45 ) ) -RRB- cord-335975-m6lkrehi 3928 46 at at IN cord-335975-m6lkrehi 3928 47 H24 H24 NNP cord-335975-m6lkrehi 3928 48 , , , cord-335975-m6lkrehi 3928 49 and and CC cord-335975-m6lkrehi 3928 50 an an DT cord-335975-m6lkrehi 3928 51 increase increase NN cord-335975-m6lkrehi 3928 52 of of IN cord-335975-m6lkrehi 3928 53 diuresis diuresis NN cord-335975-m6lkrehi 3928 54 in in IN cord-335975-m6lkrehi 3928 55 the the DT cord-335975-m6lkrehi 3928 56 6 6 CD cord-335975-m6lkrehi 3928 57 h h NN cord-335975-m6lkrehi 3928 58 period period NN cord-335975-m6lkrehi 3928 59 following follow VBG cord-335975-m6lkrehi 3928 60 initiation initiation NN cord-335975-m6lkrehi 3928 61 of of IN cord-335975-m6lkrehi 3928 62 the the DT cord-335975-m6lkrehi 3928 63 treatment treatment NN cord-335975-m6lkrehi 3928 64 ( ( -LRB- cord-335975-m6lkrehi 3928 65 p p NN cord-335975-m6lkrehi 3928 66 = = SYM cord-335975-m6lkrehi 3928 67 0.02 0.02 CD cord-335975-m6lkrehi 3928 68 ) ) -RRB- cord-335975-m6lkrehi 3928 69 . . . cord-335975-m6lkrehi 3929 1 We -PRON- PRP cord-335975-m6lkrehi 3929 2 observed observe VBD cord-335975-m6lkrehi 3929 3 an an DT cord-335975-m6lkrehi 3929 4 increase increase NN cord-335975-m6lkrehi 3929 5 of of IN cord-335975-m6lkrehi 3929 6 pH ph NN cord-335975-m6lkrehi 3929 7 , , , cord-335975-m6lkrehi 3929 8 bicarbonate bicarbonate NN cord-335975-m6lkrehi 3929 9 , , , cord-335975-m6lkrehi 3929 10 base base NN cord-335975-m6lkrehi 3929 11 excess excess NN cord-335975-m6lkrehi 3929 12 , , , cord-335975-m6lkrehi 3929 13 and and CC cord-335975-m6lkrehi 3929 14 sodium sodium NN cord-335975-m6lkrehi 3929 15 , , , cord-335975-m6lkrehi 3929 16 at at IN cord-335975-m6lkrehi 3929 17 H6 H6 NNP cord-335975-m6lkrehi 3929 18 and and CC cord-335975-m6lkrehi 3929 19 H24 H24 NNP cord-335975-m6lkrehi 3929 20 ( ( -LRB- cord-335975-m6lkrehi 3929 21 all all DT cord-335975-m6lkrehi 3929 22 p p NN cord-335975-m6lkrehi 3929 23 < < XX cord-335975-m6lkrehi 3929 24 0.0001 0.0001 CD cord-335975-m6lkrehi 3929 25 ) ) -RRB- cord-335975-m6lkrehi 3929 26 . . . cord-335975-m6lkrehi 3930 1 Plasma plasma NN cord-335975-m6lkrehi 3930 2 lactate lactate NN cord-335975-m6lkrehi 3930 3 concentration concentration NN cord-335975-m6lkrehi 3930 4 was be VBD cord-335975-m6lkrehi 3930 5 increased increase VBN cord-335975-m6lkrehi 3930 6 at at IN cord-335975-m6lkrehi 3930 7 H6 H6 NNP cord-335975-m6lkrehi 3930 8 ( ( -LRB- cord-335975-m6lkrehi 3930 9 p p NN cord-335975-m6lkrehi 3930 10 < < XX cord-335975-m6lkrehi 3930 11 0.0001 0.0001 CD cord-335975-m6lkrehi 3930 12 ) ) -RRB- cord-335975-m6lkrehi 3930 13 , , , cord-335975-m6lkrehi 3930 14 but but CC cord-335975-m6lkrehi 3930 15 was be VBD cord-335975-m6lkrehi 3930 16 not not RB cord-335975-m6lkrehi 3930 17 different different JJ cord-335975-m6lkrehi 3930 18 from from IN cord-335975-m6lkrehi 3930 19 basal basal JJ cord-335975-m6lkrehi 3930 20 value value NN cord-335975-m6lkrehi 3930 21 at at IN cord-335975-m6lkrehi 3930 22 H24 H24 NNP cord-335975-m6lkrehi 3930 23 ( ( -LRB- cord-335975-m6lkrehi 3930 24 p p NN cord-335975-m6lkrehi 3930 25 = = SYM cord-335975-m6lkrehi 3930 26 0.99 0.99 CD cord-335975-m6lkrehi 3930 27 ) ) -RRB- cord-335975-m6lkrehi 3930 28 . . . cord-335975-m6lkrehi 3931 1 There there EX cord-335975-m6lkrehi 3931 2 were be VBD cord-335975-m6lkrehi 3931 3 no no DT cord-335975-m6lkrehi 3931 4 significant significant JJ cord-335975-m6lkrehi 3931 5 variation variation NN cord-335975-m6lkrehi 3931 6 of of IN cord-335975-m6lkrehi 3931 7 plasma plasma NN cord-335975-m6lkrehi 3931 8 chloride chloride NN cord-335975-m6lkrehi 3931 9 . . . cord-335975-m6lkrehi 3932 1 Chloride chloride NN cord-335975-m6lkrehi 3932 2 sodium sodium NN cord-335975-m6lkrehi 3932 3 ratio ratio NN cord-335975-m6lkrehi 3932 4 was be VBD cord-335975-m6lkrehi 3932 5 significantly significantly RB cord-335975-m6lkrehi 3932 6 reduced reduce VBN cord-335975-m6lkrehi 3932 7 . . . cord-335975-m6lkrehi 3933 1 Plasma plasma NN cord-335975-m6lkrehi 3933 2 sodium sodium NN cord-335975-m6lkrehi 3934 1 > > XX cord-335975-m6lkrehi 3935 1 = = SYM cord-335975-m6lkrehi 3935 2 150 150 CD cord-335975-m6lkrehi 3935 3 mmol mmol JJ cord-335975-m6lkrehi 3935 4 l l NN cord-335975-m6lkrehi 3935 5 and and CC cord-335975-m6lkrehi 3936 1 pH pH NNP cord-335975-m6lkrehi 3936 2 > > XX cord-335975-m6lkrehi 3937 1 = = SYM cord-335975-m6lkrehi 3937 2 7.50 7.50 CD cord-335975-m6lkrehi 3937 3 at at IN cord-335975-m6lkrehi 3937 4 H24 H24 NNP cord-335975-m6lkrehi 3937 5 were be VBD cord-335975-m6lkrehi 3937 6 observed observe VBN cord-335975-m6lkrehi 3937 7 in in IN cord-335975-m6lkrehi 3937 8 5 5 CD cord-335975-m6lkrehi 3937 9 % % NN cord-335975-m6lkrehi 3937 10 of of IN cord-335975-m6lkrehi 3937 11 the the DT cord-335975-m6lkrehi 3937 12 patients patient NNS cord-335975-m6lkrehi 3937 13 . . . cord-335975-m6lkrehi 3938 1 This this DT cord-335975-m6lkrehi 3938 2 retrospective retrospective JJ cord-335975-m6lkrehi 3938 3 study study NN cord-335975-m6lkrehi 3938 4 reports report VBZ cord-335975-m6lkrehi 3938 5 the the DT cord-335975-m6lkrehi 3938 6 largest large JJS cord-335975-m6lkrehi 3938 7 number number NN cord-335975-m6lkrehi 3938 8 of of IN cord-335975-m6lkrehi 3938 9 critically critically RB cord-335975-m6lkrehi 3938 10 ill ill JJ cord-335975-m6lkrehi 3938 11 patients patient NNS cord-335975-m6lkrehi 3938 12 having have VBG cord-335975-m6lkrehi 3938 13 received receive VBN cord-335975-m6lkrehi 3938 14 sodium sodium NN cord-335975-m6lkrehi 3938 15 lactate lactate NN cord-335975-m6lkrehi 3938 16 . . . cord-335975-m6lkrehi 3939 1 Hemodynamic Hemodynamic NNP cord-335975-m6lkrehi 3939 2 effects effect NNS cord-335975-m6lkrehi 3939 3 observed observe VBN cord-335975-m6lkrehi 3939 4 in in IN cord-335975-m6lkrehi 3939 5 this this DT cord-335975-m6lkrehi 3939 6 study study NN cord-335975-m6lkrehi 3939 7 are be VBP cord-335975-m6lkrehi 3939 8 concordant concordant JJ cord-335975-m6lkrehi 3939 9 with with IN cord-335975-m6lkrehi 3939 10 the the DT cord-335975-m6lkrehi 3939 11 data datum NNS cord-335975-m6lkrehi 3939 12 of of IN cord-335975-m6lkrehi 3939 13 the the DT cord-335975-m6lkrehi 3939 14 literature literature NN cord-335975-m6lkrehi 3939 15 . . . cord-335975-m6lkrehi 3940 1 The the DT cord-335975-m6lkrehi 3940 2 metabolic metabolic JJ cord-335975-m6lkrehi 3940 3 effects effect NNS cord-335975-m6lkrehi 3940 4 observed observe VBN cord-335975-m6lkrehi 3940 5 in in IN cord-335975-m6lkrehi 3940 6 this this DT cord-335975-m6lkrehi 3940 7 study study NN cord-335975-m6lkrehi 3940 8 , , , cord-335975-m6lkrehi 3940 9 with with IN cord-335975-m6lkrehi 3940 10 rapid rapid JJ cord-335975-m6lkrehi 3940 11 increase increase NN cord-335975-m6lkrehi 3940 12 of of IN cord-335975-m6lkrehi 3940 13 pH ph NN cord-335975-m6lkrehi 3940 14 , , , cord-335975-m6lkrehi 3940 15 bicarbonate bicarbonate NN cord-335975-m6lkrehi 3940 16 , , , cord-335975-m6lkrehi 3940 17 and and CC cord-335975-m6lkrehi 3940 18 base base NN cord-335975-m6lkrehi 3940 19 excess excess NN cord-335975-m6lkrehi 3940 20 , , , cord-335975-m6lkrehi 3940 21 strongly strongly RB cord-335975-m6lkrehi 3940 22 suggest suggest VBP cord-335975-m6lkrehi 3940 23 the the DT cord-335975-m6lkrehi 3940 24 potential potential JJ cord-335975-m6lkrehi 3940 25 interest interest NN cord-335975-m6lkrehi 3940 26 of of IN cord-335975-m6lkrehi 3940 27 sodium sodium NN cord-335975-m6lkrehi 3940 28 lactate lactate NN cord-335975-m6lkrehi 3940 29 among among IN cord-335975-m6lkrehi 3940 30 critically critically RB cord-335975-m6lkrehi 3940 31 ill ill JJ cord-335975-m6lkrehi 3940 32 patients patient NNS cord-335975-m6lkrehi 3940 33 presenting present VBG cord-335975-m6lkrehi 3940 34 with with IN cord-335975-m6lkrehi 3940 35 acidosis acidosis NN cord-335975-m6lkrehi 3940 36 and and CC cord-335975-m6lkrehi 3940 37 increased increase VBN cord-335975-m6lkrehi 3940 38 chloride chloride NN cord-335975-m6lkrehi 3940 39 sodium sodium NN cord-335975-m6lkrehi 3940 40 ratio ratio NN cord-335975-m6lkrehi 3940 41 . . . cord-335975-m6lkrehi 3941 1 Introduction introduction NN cord-335975-m6lkrehi 3941 2 : : : cord-335975-m6lkrehi 3942 1 Acute acute JJ cord-335975-m6lkrehi 3942 2 kidney kidney NN cord-335975-m6lkrehi 3942 3 injury injury NN cord-335975-m6lkrehi 3942 4 ( ( -LRB- cord-335975-m6lkrehi 3942 5 AKI AKI NNP cord-335975-m6lkrehi 3942 6 ) ) -RRB- cord-335975-m6lkrehi 3942 7 is be VBZ cord-335975-m6lkrehi 3942 8 a a DT cord-335975-m6lkrehi 3942 9 frequent frequent JJ cord-335975-m6lkrehi 3942 10 and and CC cord-335975-m6lkrehi 3942 11 severe severe JJ cord-335975-m6lkrehi 3942 12 condition condition NN cord-335975-m6lkrehi 3942 13 in in IN cord-335975-m6lkrehi 3942 14 intensive intensive JJ cord-335975-m6lkrehi 3942 15 care care NN cord-335975-m6lkrehi 3942 16 unit unit NN cord-335975-m6lkrehi 3942 17 patients patient NNS cord-335975-m6lkrehi 3942 18 that that WDT cord-335975-m6lkrehi 3942 19 may may MD cord-335975-m6lkrehi 3942 20 require require VB cord-335975-m6lkrehi 3942 21 renal renal JJ cord-335975-m6lkrehi 3942 22 replacement replacement NN cord-335975-m6lkrehi 3942 23 therapy therapy NN cord-335975-m6lkrehi 3942 24 , , , cord-335975-m6lkrehi 3942 25 most most RBS cord-335975-m6lkrehi 3942 26 frequently frequently RB cord-335975-m6lkrehi 3942 27 continuous continuous JJ cord-335975-m6lkrehi 3942 28 renal renal JJ cord-335975-m6lkrehi 3942 29 replacement replacement NN cord-335975-m6lkrehi 3942 30 therapy therapy NN cord-335975-m6lkrehi 3942 31 ( ( -LRB- cord-335975-m6lkrehi 3942 32 CRRT CRRT NNP cord-335975-m6lkrehi 3942 33 ) ) -RRB- cord-335975-m6lkrehi 3942 34 . . . cord-335975-m6lkrehi 3943 1 Although although IN cord-335975-m6lkrehi 3943 2 hypoglycemia hypoglycemia NN cord-335975-m6lkrehi 3943 3 is be VBZ cord-335975-m6lkrehi 3943 4 a a DT cord-335975-m6lkrehi 3943 5 well well RB cord-335975-m6lkrehi 3943 6 - - HYPH cord-335975-m6lkrehi 3943 7 known know VBN cord-335975-m6lkrehi 3943 8 complication complication NN cord-335975-m6lkrehi 3943 9 of of IN cord-335975-m6lkrehi 3943 10 CRRT CRRT NNP cord-335975-m6lkrehi 3943 11 using use VBG cord-335975-m6lkrehi 3943 12 glucose glucose NN cord-335975-m6lkrehi 3943 13 free free JJ cord-335975-m6lkrehi 3943 14 solutions solution NNS cord-335975-m6lkrehi 3943 15 , , , cord-335975-m6lkrehi 3943 16 euglycemic euglycemic JJ cord-335975-m6lkrehi 3943 17 ketoacidosis ketoacidosis NN cord-335975-m6lkrehi 3943 18 ( ( -LRB- cord-335975-m6lkrehi 3943 19 EKA EKA NNP cord-335975-m6lkrehi 3943 20 ) ) -RRB- cord-335975-m6lkrehi 3943 21 has have VBZ cord-335975-m6lkrehi 3943 22 never never RB cord-335975-m6lkrehi 3943 23 been be VBN cord-335975-m6lkrehi 3943 24 described describe VBN cord-335975-m6lkrehi 3943 25 in in IN cord-335975-m6lkrehi 3943 26 this this DT cord-335975-m6lkrehi 3943 27 setting setting NN cord-335975-m6lkrehi 3943 28 . . . cord-335975-m6lkrehi 3944 1 Patients patient NNS cord-335975-m6lkrehi 3944 2 and and CC cord-335975-m6lkrehi 3944 3 methods method NNS cord-335975-m6lkrehi 3945 1 : : : cord-335975-m6lkrehi 3945 2 All all DT cord-335975-m6lkrehi 3945 3 anuric anuric JJ cord-335975-m6lkrehi 3945 4 patients patient NNS cord-335975-m6lkrehi 3945 5 with with IN cord-335975-m6lkrehi 3945 6 glucose glucose NN cord-335975-m6lkrehi 3945 7 free free JJ cord-335975-m6lkrehi 3945 8 CRRT CRRT NNP cord-335975-m6lkrehi 3945 9 solution solution NN cord-335975-m6lkrehi 3945 10 induced induce VBN cord-335975-m6lkrehi 3945 11 EKA EKA NNP cord-335975-m6lkrehi 3945 12 ( ( -LRB- cord-335975-m6lkrehi 3945 13 February February NNP cord-335975-m6lkrehi 3945 14 2017-May 2017-may CD cord-335975-m6lkrehi 3945 15 2017 2017 CD cord-335975-m6lkrehi 3945 16 ) ) -RRB- cord-335975-m6lkrehi 3945 17 were be VBD cord-335975-m6lkrehi 3945 18 prospectively prospectively RB cord-335975-m6lkrehi 3945 19 included include VBN cord-335975-m6lkrehi 3945 20 and and CC cord-335975-m6lkrehi 3945 21 evaluated evaluate VBN cord-335975-m6lkrehi 3945 22 . . . cord-335975-m6lkrehi 3946 1 Ketoacidosis ketoacidosis NN cord-335975-m6lkrehi 3946 2 was be VBD cord-335975-m6lkrehi 3946 3 deemed deem VBN cord-335975-m6lkrehi 3946 4 possible possible JJ cord-335975-m6lkrehi 3946 5 when when WRB cord-335975-m6lkrehi 3946 6 nonlactic nonlactic JJ cord-335975-m6lkrehi 3946 7 metabolic metabolic JJ cord-335975-m6lkrehi 3946 8 acidosis acidosis NN cord-335975-m6lkrehi 3946 9 did do VBD cord-335975-m6lkrehi 3946 10 not not RB cord-335975-m6lkrehi 3946 11 improve improve VB cord-335975-m6lkrehi 3946 12 in in IN cord-335975-m6lkrehi 3946 13 patients patient NNS cord-335975-m6lkrehi 3946 14 on on IN cord-335975-m6lkrehi 3946 15 CRRT CRRT NNP cord-335975-m6lkrehi 3946 16 . . . cord-335975-m6lkrehi 3947 1 Because because IN cord-335975-m6lkrehi 3947 2 all all DT cord-335975-m6lkrehi 3947 3 patients patient NNS cord-335975-m6lkrehi 3947 4 were be VBD cord-335975-m6lkrehi 3947 5 anuric anuric JJ cord-335975-m6lkrehi 3947 6 , , , cord-335975-m6lkrehi 3947 7 we -PRON- PRP cord-335975-m6lkrehi 3947 8 measured measure VBD cord-335975-m6lkrehi 3947 9 ketonemia ketonemia NNP cord-335975-m6lkrehi 3947 10 and and CC cord-335975-m6lkrehi 3947 11 used use VBD cord-335975-m6lkrehi 3947 12 urinary urinary JJ cord-335975-m6lkrehi 3947 13 test test NN cord-335975-m6lkrehi 3947 14 strip strip NN cord-335975-m6lkrehi 3947 15 in in IN cord-335975-m6lkrehi 3947 16 the the DT cord-335975-m6lkrehi 3947 17 effluent effluent NN cord-335975-m6lkrehi 3947 18 fluid fluid NN cord-335975-m6lkrehi 3947 19 . . . cord-335975-m6lkrehi 3948 1 EKA EKA NNP cord-335975-m6lkrehi 3948 2 diagnosis diagnosis NN cord-335975-m6lkrehi 3948 3 was be VBD cord-335975-m6lkrehi 3948 4 retained retain VBN cord-335975-m6lkrehi 3948 5 when when WRB cord-335975-m6lkrehi 3948 6 arterial arterial JJ cord-335975-m6lkrehi 3948 7 serum serum NN cord-335975-m6lkrehi 3948 8 bicarbonate bicarbonate NN cord-335975-m6lkrehi 3948 9 was be VBD cord-335975-m6lkrehi 3948 10 < < XX cord-335975-m6lkrehi 3948 11 20 20 CD cord-335975-m6lkrehi 3948 12 mEg mEg NNS cord-335975-m6lkrehi 3948 13 / / SYM cord-335975-m6lkrehi 3948 14 l l NN cord-335975-m6lkrehi 3948 15 despite despite IN cord-335975-m6lkrehi 3948 16 CRRT CRRT NNP cord-335975-m6lkrehi 3948 17 , , , cord-335975-m6lkrehi 3948 18 in in IN cord-335975-m6lkrehi 3948 19 the the DT cord-335975-m6lkrehi 3948 20 absence absence NN cord-335975-m6lkrehi 3948 21 of of IN cord-335975-m6lkrehi 3948 22 lactic lactic JJ cord-335975-m6lkrehi 3948 23 acidosis acidosis NN cord-335975-m6lkrehi 3948 24 and and CC cord-335975-m6lkrehi 3948 25 in in IN cord-335975-m6lkrehi 3948 26 the the DT cord-335975-m6lkrehi 3948 27 presence presence NN cord-335975-m6lkrehi 3948 28 of of IN cord-335975-m6lkrehi 3948 29 ketones ketone NNS cord-335975-m6lkrehi 3948 30 in in IN cord-335975-m6lkrehi 3948 31 the the DT cord-335975-m6lkrehi 3948 32 serum serum NN cord-335975-m6lkrehi 3948 33 or or CC cord-335975-m6lkrehi 3948 34 CRRT CRRT NNP cord-335975-m6lkrehi 3948 35 effluent effluent NN cord-335975-m6lkrehi 3948 36 fluid fluid NN cord-335975-m6lkrehi 3948 37 . . . cord-335975-m6lkrehi 3949 1 Results result NNS cord-335975-m6lkrehi 3949 2 : : : cord-335975-m6lkrehi 3950 1 Eighteen eighteen CD cord-335975-m6lkrehi 3950 2 patients patient NNS cord-335975-m6lkrehi 3950 3 ( ( -LRB- cord-335975-m6lkrehi 3950 4 15 15 CD cord-335975-m6lkrehi 3950 5 % % NN cord-335975-m6lkrehi 3950 6 of of IN cord-335975-m6lkrehi 3950 7 our -PRON- PRP$ cord-335975-m6lkrehi 3950 8 patients patient NNS cord-335975-m6lkrehi 3950 9 under under IN cord-335975-m6lkrehi 3950 10 CRRT CRRT NNP cord-335975-m6lkrehi 3950 11 in in IN cord-335975-m6lkrehi 3950 12 this this DT cord-335975-m6lkrehi 3950 13 period period NN cord-335975-m6lkrehi 3950 14 ) ) -RRB- cord-335975-m6lkrehi 3950 15 developed develop VBD cord-335975-m6lkrehi 3950 16 EKA EKA NNP cord-335975-m6lkrehi 3950 17 during during IN cord-335975-m6lkrehi 3950 18 CRRT CRRT NNP cord-335975-m6lkrehi 3950 19 using use VBG cord-335975-m6lkrehi 3950 20 glucose glucose NN cord-335975-m6lkrehi 3950 21 free free JJ cord-335975-m6lkrehi 3950 22 solution solution NN cord-335975-m6lkrehi 3950 23 ( ( -LRB- cord-335975-m6lkrehi 3950 24 Phoxilium Phoxilium NNP cord-335975-m6lkrehi 3950 25 ® ® '' cord-335975-m6lkrehi 3950 26 ) ) -RRB- cord-335975-m6lkrehi 3950 27 . . . cord-335975-m6lkrehi 3951 1 Time time NN cord-335975-m6lkrehi 3951 2 between between IN cord-335975-m6lkrehi 3951 3 CVVHDF CVVHDF NNP cord-335975-m6lkrehi 3951 4 initiation initiation NN cord-335975-m6lkrehi 3951 5 and and CC cord-335975-m6lkrehi 3951 6 ketonemia ketonemia NNP cord-335975-m6lkrehi 3951 7 detection detection NN cord-335975-m6lkrehi 3951 8 was be VBD cord-335975-m6lkrehi 3951 9 2 2 CD cord-335975-m6lkrehi 3951 10 ( ( -LRB- cord-335975-m6lkrehi 3951 11 1 1 CD cord-335975-m6lkrehi 3951 12 - - SYM cord-335975-m6lkrehi 3951 13 3 3 CD cord-335975-m6lkrehi 3951 14 ) ) -RRB- cord-335975-m6lkrehi 3951 15 days day NNS cord-335975-m6lkrehi 3951 16 . . . cord-335975-m6lkrehi 3952 1 Patient patient JJ cord-335975-m6lkrehi 3952 2 characteristics characteristic NNS cord-335975-m6lkrehi 3952 3 are be VBP cord-335975-m6lkrehi 3952 4 presented present VBN cord-335975-m6lkrehi 3952 5 in in IN cord-335975-m6lkrehi 3952 6 the the DT cord-335975-m6lkrehi 3952 7 Table Table NNP cord-335975-m6lkrehi 3952 8 1 1 CD cord-335975-m6lkrehi 3952 9 . . . cord-335975-m6lkrehi 3953 1 Half half NN cord-335975-m6lkrehi 3953 2 of of IN cord-335975-m6lkrehi 3953 3 them -PRON- PRP cord-335975-m6lkrehi 3953 4 had have VBD cord-335975-m6lkrehi 3953 5 for for IN cord-335975-m6lkrehi 3953 6 a a DT cord-335975-m6lkrehi 3953 7 medical medical JJ cord-335975-m6lkrehi 3953 8 history history NN cord-335975-m6lkrehi 3953 9 of of IN cord-335975-m6lkrehi 3953 10 diabetes diabete NNS cord-335975-m6lkrehi 3953 11 ( ( -LRB- cord-335975-m6lkrehi 3953 12 5 5 CD cord-335975-m6lkrehi 3953 13 insulindependent insulindependent NN cord-335975-m6lkrehi 3953 14 ) ) -RRB- cord-335975-m6lkrehi 3953 15 . . . cord-335975-m6lkrehi 3954 1 Only only RB cord-335975-m6lkrehi 3954 2 3 3 CD cord-335975-m6lkrehi 3954 3 patients patient NNS cord-335975-m6lkrehi 3954 4 were be VBD cord-335975-m6lkrehi 3954 5 receiving receive VBG cord-335975-m6lkrehi 3954 6 insulin insulin NN cord-335975-m6lkrehi 3954 7 and and CC cord-335975-m6lkrehi 3954 8 most most JJS cord-335975-m6lkrehi 3954 9 of of IN cord-335975-m6lkrehi 3954 10 them -PRON- PRP cord-335975-m6lkrehi 3954 11 had have VBD cord-335975-m6lkrehi 3954 12 low low JJ cord-335975-m6lkrehi 3954 13 glucose glucose NN cord-335975-m6lkrehi 3954 14 or or CC cord-335975-m6lkrehi 3954 15 food food NN cord-335975-m6lkrehi 3954 16 intake intake NN cord-335975-m6lkrehi 3954 17 . . . cord-335975-m6lkrehi 3955 1 Increasing increase VBG cord-335975-m6lkrehi 3955 2 glucose glucose NN cord-335975-m6lkrehi 3955 3 intake intake NN cord-335975-m6lkrehi 3955 4 and and CC cord-335975-m6lkrehi 3955 5 insulin insulin NN cord-335975-m6lkrehi 3955 6 infusion infusion NN cord-335975-m6lkrehi 3955 7 resolved resolve VBD cord-335975-m6lkrehi 3955 8 ketonemia ketonemia NN cord-335975-m6lkrehi 3955 9 in in IN cord-335975-m6lkrehi 3955 10 all all DT cord-335975-m6lkrehi 3955 11 cases case NNS cord-335975-m6lkrehi 3955 12 . . . cord-335975-m6lkrehi 3956 1 Discussion discussion NN cord-335975-m6lkrehi 3956 2 : : : cord-335975-m6lkrehi 3957 1 We -PRON- PRP cord-335975-m6lkrehi 3957 2 describe describe VBP cord-335975-m6lkrehi 3957 3 for for IN cord-335975-m6lkrehi 3957 4 the the DT cord-335975-m6lkrehi 3957 5 first first JJ cord-335975-m6lkrehi 3957 6 time time NN cord-335975-m6lkrehi 3957 7 the the DT cord-335975-m6lkrehi 3957 8 occurrence occurrence NN cord-335975-m6lkrehi 3957 9 of of IN cord-335975-m6lkrehi 3957 10 euglycemic euglycemic JJ cord-335975-m6lkrehi 3957 11 ketoacidosis ketoacidosis NN cord-335975-m6lkrehi 3957 12 in in IN cord-335975-m6lkrehi 3957 13 critically critically RB cord-335975-m6lkrehi 3957 14 ill ill JJ cord-335975-m6lkrehi 3957 15 patients patient NNS cord-335975-m6lkrehi 3957 16 under under IN cord-335975-m6lkrehi 3957 17 CRRT CRRT NNP cord-335975-m6lkrehi 3957 18 using use VBG cord-335975-m6lkrehi 3957 19 glucose glucose NN cord-335975-m6lkrehi 3957 20 - - HYPH cord-335975-m6lkrehi 3957 21 free free JJ cord-335975-m6lkrehi 3957 22 replacement replacement NN cord-335975-m6lkrehi 3957 23 solution solution NN cord-335975-m6lkrehi 3957 24 . . . cord-335975-m6lkrehi 3958 1 Common common JJ cord-335975-m6lkrehi 3958 2 features feature NNS cord-335975-m6lkrehi 3958 3 of of IN cord-335975-m6lkrehi 3958 4 the the DT cord-335975-m6lkrehi 3958 5 patients patient NNS cord-335975-m6lkrehi 3958 6 were be VBD cord-335975-m6lkrehi 3958 7 multiple multiple JJ cord-335975-m6lkrehi 3958 8 organ organ NN cord-335975-m6lkrehi 3958 9 failure failure NN cord-335975-m6lkrehi 3958 10 with with IN cord-335975-m6lkrehi 3958 11 anuria anuria NNP cord-335975-m6lkrehi 3958 12 , , , cord-335975-m6lkrehi 3958 13 normal normal JJ cord-335975-m6lkrehi 3958 14 glycemia glycemia NN cord-335975-m6lkrehi 3958 15 without without IN cord-335975-m6lkrehi 3958 16 insulin insulin NN cord-335975-m6lkrehi 3958 17 infusion infusion NN cord-335975-m6lkrehi 3958 18 and and CC cord-335975-m6lkrehi 3958 19 low low JJ cord-335975-m6lkrehi 3958 20 glucose glucose NN cord-335975-m6lkrehi 3958 21 infusion infusion NN cord-335975-m6lkrehi 3958 22 or or CC cord-335975-m6lkrehi 3958 23 food food NN cord-335975-m6lkrehi 3958 24 intake intake NN cord-335975-m6lkrehi 3958 25 . . . cord-335975-m6lkrehi 3959 1 Critical critical JJ cord-335975-m6lkrehi 3959 2 illness illness NN cord-335975-m6lkrehi 3959 3 - - HYPH cord-335975-m6lkrehi 3959 4 induced induce VBN cord-335975-m6lkrehi 3959 5 insulin insulin NN cord-335975-m6lkrehi 3959 6 resistance resistance NN cord-335975-m6lkrehi 3959 7 and and CC cord-335975-m6lkrehi 3959 8 starvation starvation NN cord-335975-m6lkrehi 3959 9 could could MD cord-335975-m6lkrehi 3959 10 altogether altogether RB cord-335975-m6lkrehi 3959 11 contribute contribute VB cord-335975-m6lkrehi 3959 12 to to IN cord-335975-m6lkrehi 3959 13 ketoacidosis ketoacidosis NN cord-335975-m6lkrehi 3959 14 even even RB cord-335975-m6lkrehi 3959 15 if if IN cord-335975-m6lkrehi 3959 16 acidosis acidosis NN cord-335975-m6lkrehi 3959 17 is be VBZ cord-335975-m6lkrehi 3959 18 unusual unusual JJ cord-335975-m6lkrehi 3959 19 in in IN cord-335975-m6lkrehi 3959 20 starvation starvation NN cord-335975-m6lkrehi 3959 21 ketosis ketosis NN cord-335975-m6lkrehi 3959 22 . . . cord-335975-m6lkrehi 3960 1 By by IN cord-335975-m6lkrehi 3960 2 removing remove VBG cord-335975-m6lkrehi 3960 3 substantial substantial JJ cord-335975-m6lkrehi 3960 4 amounts amount NNS cord-335975-m6lkrehi 3960 5 of of IN cord-335975-m6lkrehi 3960 6 glucose glucose NN cord-335975-m6lkrehi 3960 7 from from IN cord-335975-m6lkrehi 3960 8 the the DT cord-335975-m6lkrehi 3960 9 blood blood NN cord-335975-m6lkrehi 3960 10 , , , cord-335975-m6lkrehi 3960 11 CRRT CRRT NNP cord-335975-m6lkrehi 3960 12 with with IN cord-335975-m6lkrehi 3960 13 glucose glucose NN cord-335975-m6lkrehi 3960 14 free free JJ cord-335975-m6lkrehi 3960 15 solution solution NN cord-335975-m6lkrehi 3960 16 could could MD cord-335975-m6lkrehi 3960 17 worsen worsen VB cord-335975-m6lkrehi 3960 18 this this DT cord-335975-m6lkrehi 3960 19 condition condition NN cord-335975-m6lkrehi 3960 20 , , , cord-335975-m6lkrehi 3960 21 mask mask NN cord-335975-m6lkrehi 3960 22 hyperglycemia hyperglycemia NN cord-335975-m6lkrehi 3960 23 and and CC cord-335975-m6lkrehi 3960 24 induce induce VB cord-335975-m6lkrehi 3960 25 euglycemic euglycemic JJ cord-335975-m6lkrehi 3960 26 ketoacidosis ketoacidosis NN cord-335975-m6lkrehi 3960 27 . . . cord-335975-m6lkrehi 3961 1 In in IN cord-335975-m6lkrehi 3961 2 critically critically RB cord-335975-m6lkrehi 3961 3 ill ill JJ cord-335975-m6lkrehi 3961 4 patients patient NNS cord-335975-m6lkrehi 3961 5 on on IN cord-335975-m6lkrehi 3961 6 CRRT CRRT NNP cord-335975-m6lkrehi 3961 7 using use VBG cord-335975-m6lkrehi 3961 8 glucose glucose NN cord-335975-m6lkrehi 3961 9 free free JJ cord-335975-m6lkrehi 3961 10 solution solution NN cord-335975-m6lkrehi 3961 11 , , , cord-335975-m6lkrehi 3961 12 euglycemic euglycemic JJ cord-335975-m6lkrehi 3961 13 ketoacidosis ketoacidosis NN cord-335975-m6lkrehi 3961 14 is be VBZ cord-335975-m6lkrehi 3961 15 common common JJ cord-335975-m6lkrehi 3961 16 and and CC cord-335975-m6lkrehi 3961 17 should should MD cord-335975-m6lkrehi 3961 18 be be VB cord-335975-m6lkrehi 3961 19 detected detect VBN cord-335975-m6lkrehi 3961 20 , , , cord-335975-m6lkrehi 3961 21 especially especially RB cord-335975-m6lkrehi 3961 22 in in IN cord-335975-m6lkrehi 3961 23 patients patient NNS cord-335975-m6lkrehi 3961 24 with with IN cord-335975-m6lkrehi 3961 25 low low JJ cord-335975-m6lkrehi 3961 26 glucose glucose NN cord-335975-m6lkrehi 3961 27 intake intake NN cord-335975-m6lkrehi 3961 28 , , , cord-335975-m6lkrehi 3961 29 no no DT cord-335975-m6lkrehi 3961 30 insulin insulin NN cord-335975-m6lkrehi 3961 31 infusion infusion NN cord-335975-m6lkrehi 3961 32 and and CC cord-335975-m6lkrehi 3961 33 unexplained unexplained JJ cord-335975-m6lkrehi 3961 34 metabolic metabolic JJ cord-335975-m6lkrehi 3961 35 acidosis acidosis NN cord-335975-m6lkrehi 3961 36 . . . cord-335975-m6lkrehi 3962 1 Importantly importantly RB cord-335975-m6lkrehi 3962 2 , , , cord-335975-m6lkrehi 3962 3 the the DT cord-335975-m6lkrehi 3962 4 diagnosis diagnosis NN cord-335975-m6lkrehi 3962 5 can can MD cord-335975-m6lkrehi 3962 6 be be VB cord-335975-m6lkrehi 3962 7 missed miss VBN cord-335975-m6lkrehi 3962 8 in in IN cord-335975-m6lkrehi 3962 9 anuric anuric JJ cord-335975-m6lkrehi 3962 10 patients patient NNS cord-335975-m6lkrehi 3962 11 with with IN cord-335975-m6lkrehi 3962 12 normal normal JJ cord-335975-m6lkrehi 3962 13 blood blood NN cord-335975-m6lkrehi 3962 14 glucose glucose NN cord-335975-m6lkrehi 3962 15 and and CC cord-335975-m6lkrehi 3962 16 in in IN cord-335975-m6lkrehi 3962 17 the the DT cord-335975-m6lkrehi 3962 18 absence absence NN cord-335975-m6lkrehi 3962 19 of of IN cord-335975-m6lkrehi 3962 20 known know VBN cord-335975-m6lkrehi 3962 21 diabetes diabetes NN cord-335975-m6lkrehi 3962 22 . . . cord-335975-m6lkrehi 3963 1 Since since IN cord-335975-m6lkrehi 3963 2 , , , cord-335975-m6lkrehi 3963 3 CVVHDF CVVHDF NNP cord-335975-m6lkrehi 3963 4 - - HYPH cord-335975-m6lkrehi 3963 5 induced induce VBN cord-335975-m6lkrehi 3963 6 ketoacidosis ketoacidosis NN cord-335975-m6lkrehi 3963 7 may may MD cord-335975-m6lkrehi 3963 8 contribute contribute VB cord-335975-m6lkrehi 3963 9 to to IN cord-335975-m6lkrehi 3963 10 persistent persistent JJ cord-335975-m6lkrehi 3963 11 acidemia acidemia NN cord-335975-m6lkrehi 3963 12 and and CC cord-335975-m6lkrehi 3963 13 its -PRON- PRP$ cord-335975-m6lkrehi 3963 14 adverse adverse JJ cord-335975-m6lkrehi 3963 15 effects effect NNS cord-335975-m6lkrehi 3963 16 , , , cord-335975-m6lkrehi 3963 17 serum serum NN cord-335975-m6lkrehi 3963 18 or or CC cord-335975-m6lkrehi 3963 19 CRRT CRRT NNP cord-335975-m6lkrehi 3963 20 effluent effluent NN cord-335975-m6lkrehi 3963 21 fluid fluid JJ cord-335975-m6lkrehi 3963 22 ketone ketone NN cord-335975-m6lkrehi 3963 23 level level NN cord-335975-m6lkrehi 3963 24 should should MD cord-335975-m6lkrehi 3963 25 be be VB cord-335975-m6lkrehi 3963 26 measured measure VBN cord-335975-m6lkrehi 3963 27 in in IN cord-335975-m6lkrehi 3963 28 this this DT cord-335975-m6lkrehi 3963 29 setting setting NN cord-335975-m6lkrehi 3963 30 . . . cord-335975-m6lkrehi 3964 1 39.5 39.5 CD cord-335975-m6lkrehi 3964 2 - - SYM cord-335975-m6lkrehi 3964 3 67 67 CD cord-335975-m6lkrehi 3964 4 ] ] -RRB- cord-335975-m6lkrehi 3964 5 years year NNS cord-335975-m6lkrehi 3964 6 . . . cord-335975-m6lkrehi 3965 1 Main main JJ cord-335975-m6lkrehi 3965 2 reasons reason NNS cord-335975-m6lkrehi 3965 3 for for IN cord-335975-m6lkrehi 3965 4 admission admission NN cord-335975-m6lkrehi 3965 5 were be VBD cord-335975-m6lkrehi 3965 6 hypercalcemia hypercalcemia NN cord-335975-m6lkrehi 3966 1 ( ( -LRB- cord-335975-m6lkrehi 3966 2 n n NN cord-335975-m6lkrehi 3966 3 = = SYM cord-335975-m6lkrehi 3966 4 55 55 CD cord-335975-m6lkrehi 3966 5 ( ( -LRB- cord-335975-m6lkrehi 3966 6 70.5 70.5 CD cord-335975-m6lkrehi 3966 7 % % NN cord-335975-m6lkrehi 3966 8 ) ) -RRB- cord-335975-m6lkrehi 3966 9 ) ) -RRB- cord-335975-m6lkrehi 3966 10 , , , cord-335975-m6lkrehi 3966 11 followed follow VBN cord-335975-m6lkrehi 3966 12 by by IN cord-335975-m6lkrehi 3966 13 acute acute JJ cord-335975-m6lkrehi 3966 14 encephalopathy encephalopathy NN cord-335975-m6lkrehi 3966 15 ( ( -LRB- cord-335975-m6lkrehi 3966 16 n n NN cord-335975-m6lkrehi 3966 17 = = NN cord-335975-m6lkrehi 3966 18 9 9 CD cord-335975-m6lkrehi 3966 19 ( ( -LRB- cord-335975-m6lkrehi 3966 20 11.5 11.5 CD cord-335975-m6lkrehi 3966 21 % % NN cord-335975-m6lkrehi 3966 22 ) ) -RRB- cord-335975-m6lkrehi 3966 23 ) ) -RRB- cord-335975-m6lkrehi 3966 24 . . . cord-335975-m6lkrehi 3967 1 Median median JJ cord-335975-m6lkrehi 3967 2 SAPS SAPS NNP cord-335975-m6lkrehi 3967 3 II II NNP cord-335975-m6lkrehi 3967 4 and and CC cord-335975-m6lkrehi 3967 5 SOFA sofa NN cord-335975-m6lkrehi 3967 6 scores score NNS cord-335975-m6lkrehi 3967 7 were be VBD cord-335975-m6lkrehi 3967 8 32 32 CD cord-335975-m6lkrehi 3967 9 [ [ -LRB- cord-335975-m6lkrehi 3967 10 22.25 22.25 CD cord-335975-m6lkrehi 3967 11 - - SYM cord-335975-m6lkrehi 3967 12 39.5 39.5 CD cord-335975-m6lkrehi 3967 13 ] ] -RRB- cord-335975-m6lkrehi 3967 14 and and CC cord-335975-m6lkrehi 3967 15 3 3 CD cord-335975-m6lkrehi 3967 16 [ [ -LRB- cord-335975-m6lkrehi 3967 17 1 1 CD cord-335975-m6lkrehi 3967 18 ] ] -RRB- cord-335975-m6lkrehi 3967 19 [ [ -LRB- cord-335975-m6lkrehi 3967 20 2 2 CD cord-335975-m6lkrehi 3967 21 ] ] -RRB- cord-335975-m6lkrehi 3967 22 [ [ -LRB- cord-335975-m6lkrehi 3967 23 3 3 CD cord-335975-m6lkrehi 3967 24 ] ] -RRB- cord-335975-m6lkrehi 3967 25 [ [ -LRB- cord-335975-m6lkrehi 3967 26 4 4 CD cord-335975-m6lkrehi 3967 27 ] ] -RRB- cord-335975-m6lkrehi 3967 28 [ [ -LRB- cord-335975-m6lkrehi 3967 29 5 5 CD cord-335975-m6lkrehi 3967 30 ] ] -RRB- cord-335975-m6lkrehi 3967 31 respectively respectively RB cord-335975-m6lkrehi 3967 32 . . . cord-335975-m6lkrehi 3968 1 Main main JJ cord-335975-m6lkrehi 3968 2 causes cause NNS cord-335975-m6lkrehi 3968 3 of of IN cord-335975-m6lkrehi 3968 4 HCM HCM NNP cord-335975-m6lkrehi 3968 5 were be VBD cord-335975-m6lkrehi 3968 6 hematological hematological JJ cord-335975-m6lkrehi 3968 7 malignancies malignancy NNS cord-335975-m6lkrehi 3968 8 ( ( -LRB- cord-335975-m6lkrehi 3969 1 n n NN cord-335975-m6lkrehi 3969 2 = = SYM cord-335975-m6lkrehi 3969 3 46 46 CD cord-335975-m6lkrehi 3969 4 ( ( -LRB- cord-335975-m6lkrehi 3969 5 59 59 CD cord-335975-m6lkrehi 3969 6 % % NN cord-335975-m6lkrehi 3969 7 ) ) -RRB- cord-335975-m6lkrehi 3969 8 ) ) -RRB- cord-335975-m6lkrehi 3970 1 , , , cord-335975-m6lkrehi 3970 2 solid solid JJ cord-335975-m6lkrehi 3970 3 tumors tumor NNS cord-335975-m6lkrehi 3970 4 ( ( -LRB- cord-335975-m6lkrehi 3971 1 n n NN cord-335975-m6lkrehi 3971 2 = = SYM cord-335975-m6lkrehi 3971 3 15 15 CD cord-335975-m6lkrehi 3971 4 ( ( -LRB- cord-335975-m6lkrehi 3971 5 19 19 CD cord-335975-m6lkrehi 3971 6 % % NN cord-335975-m6lkrehi 3971 7 ) ) -RRB- cord-335975-m6lkrehi 3971 8 ) ) -RRB- cord-335975-m6lkrehi 3971 9 , , , cord-335975-m6lkrehi 3971 10 iatrogenic iatrogenic JJ cord-335975-m6lkrehi 3971 11 events event NNS cord-335975-m6lkrehi 3971 12 ( ( -LRB- cord-335975-m6lkrehi 3972 1 n n NN cord-335975-m6lkrehi 3972 2 = = SYM cord-335975-m6lkrehi 3972 3 9 9 CD cord-335975-m6lkrehi 3972 4 ( ( -LRB- cord-335975-m6lkrehi 3972 5 9 9 CD cord-335975-m6lkrehi 3972 6 % % NN cord-335975-m6lkrehi 3972 7 ) ) -RRB- cord-335975-m6lkrehi 3972 8 ) ) -RRB- cord-335975-m6lkrehi 3972 9 and and CC cord-335975-m6lkrehi 3972 10 endocrinopathies endocrinopathie NNS cord-335975-m6lkrehi 3972 11 ( ( -LRB- cord-335975-m6lkrehi 3972 12 n n NN cord-335975-m6lkrehi 3972 13 = = SYM cord-335975-m6lkrehi 3972 14 5 5 CD cord-335975-m6lkrehi 3972 15 ( ( -LRB- cord-335975-m6lkrehi 3972 16 6 6 CD cord-335975-m6lkrehi 3972 17 % % NN cord-335975-m6lkrehi 3972 18 ) ) -RRB- cord-335975-m6lkrehi 3972 19 ) ) -RRB- cord-335975-m6lkrehi 3972 20 . . . cord-335975-m6lkrehi 3973 1 Median median JJ cord-335975-m6lkrehi 3973 2 calcium calcium NN cord-335975-m6lkrehi 3973 3 levels level NNS cord-335975-m6lkrehi 3973 4 at at IN cord-335975-m6lkrehi 3973 5 admission admission NN cord-335975-m6lkrehi 3973 6 , , , cord-335975-m6lkrehi 3973 7 at at IN cord-335975-m6lkrehi 3973 8 day day NN cord-335975-m6lkrehi 3973 9 3 3 CD cord-335975-m6lkrehi 3973 10 and and CC cord-335975-m6lkrehi 3973 11 at at IN cord-335975-m6lkrehi 3973 12 ICU ICU NNP cord-335975-m6lkrehi 3973 13 discharge discharge NN cord-335975-m6lkrehi 3973 14 were be VBD cord-335975-m6lkrehi 3973 15 3.68 3.68 CD cord-335975-m6lkrehi 3973 16 [ [ -LRB- cord-335975-m6lkrehi 3973 17 3.43 3.43 CD cord-335975-m6lkrehi 3973 18 - - SYM cord-335975-m6lkrehi 3973 19 4.21 4.21 CD cord-335975-m6lkrehi 3973 20 ] ] -RRB- cord-335975-m6lkrehi 3973 21 , , , cord-335975-m6lkrehi 3973 22 2.75 2.75 CD cord-335975-m6lkrehi 3973 23 [ [ -LRB- cord-335975-m6lkrehi 3973 24 2.55 2.55 CD cord-335975-m6lkrehi 3973 25 - - SYM cord-335975-m6lkrehi 3973 26 3.12 3.12 CD cord-335975-m6lkrehi 3973 27 ] ] -RRB- cord-335975-m6lkrehi 3973 28 and and CC cord-335975-m6lkrehi 3973 29 2.56 2.56 CD cord-335975-m6lkrehi 3973 30 [ [ -LRB- cord-335975-m6lkrehi 3973 31 2.15 2.15 CD cord-335975-m6lkrehi 3973 32 - - SYM cord-335975-m6lkrehi 3973 33 3 3 CD cord-335975-m6lkrehi 3973 34 . . . cord-335975-m6lkrehi 3974 1 14 14 LS cord-335975-m6lkrehi 3974 2 ] ] -RRB- cord-335975-m6lkrehi 3974 3 mmol mmol JJ cord-335975-m6lkrehi 3974 4 L l NN cord-335975-m6lkrehi 3974 5 respectively respectively RB cord-335975-m6lkrehi 3974 6 . . . cord-335975-m6lkrehi 3975 1 More More JJR cord-335975-m6lkrehi 3975 2 than than IN cord-335975-m6lkrehi 3975 3 half half NN cord-335975-m6lkrehi 3975 4 of of IN cord-335975-m6lkrehi 3975 5 the the DT cord-335975-m6lkrehi 3975 6 patients patient NNS cord-335975-m6lkrehi 3975 7 ( ( -LRB- cord-335975-m6lkrehi 3975 8 n n NN cord-335975-m6lkrehi 3975 9 = = SYM cord-335975-m6lkrehi 3975 10 46 46 CD cord-335975-m6lkrehi 3975 11 ( ( -LRB- cord-335975-m6lkrehi 3975 12 59 59 CD cord-335975-m6lkrehi 3975 13 % % NN cord-335975-m6lkrehi 3975 14 ) ) -RRB- cord-335975-m6lkrehi 3975 15 ) ) -RRB- cord-335975-m6lkrehi 3975 16 recovered recover VBD cord-335975-m6lkrehi 3975 17 from from IN cord-335975-m6lkrehi 3975 18 HCM HCM NNP cord-335975-m6lkrehi 3975 19 5 5 CD cord-335975-m6lkrehi 3975 20 days day NNS cord-335975-m6lkrehi 3975 21 after after IN cord-335975-m6lkrehi 3975 22 ICU ICU NNP cord-335975-m6lkrehi 3975 23 admission admission NN cord-335975-m6lkrehi 3975 24 . . . cord-335975-m6lkrehi 3976 1 Acute acute JJ cord-335975-m6lkrehi 3976 2 kidney kidney NN cord-335975-m6lkrehi 3976 3 injury injury NN cord-335975-m6lkrehi 3976 4 occurred occur VBD cord-335975-m6lkrehi 3976 5 in in IN cord-335975-m6lkrehi 3976 6 65 65 CD cord-335975-m6lkrehi 3976 7 ( ( -LRB- cord-335975-m6lkrehi 3976 8 83 83 CD cord-335975-m6lkrehi 3976 9 % % NN cord-335975-m6lkrehi 3976 10 ) ) -RRB- cord-335975-m6lkrehi 3976 11 patients patient NNS cord-335975-m6lkrehi 3976 12 and and CC cord-335975-m6lkrehi 3976 13 19 19 CD cord-335975-m6lkrehi 3976 14 ( ( -LRB- cord-335975-m6lkrehi 3976 15 29.2 29.2 CD cord-335975-m6lkrehi 3976 16 % % NN cord-335975-m6lkrehi 3976 17 ) ) -RRB- cord-335975-m6lkrehi 3976 18 patients patient NNS cord-335975-m6lkrehi 3976 19 required require VBD cord-335975-m6lkrehi 3976 20 dialysis dialysis NN cord-335975-m6lkrehi 3976 21 . . . cord-335975-m6lkrehi 3977 1 Neurological neurological JJ cord-335975-m6lkrehi 3977 2 complications complication NNS cord-335975-m6lkrehi 3977 3 concerned concern VBD cord-335975-m6lkrehi 3977 4 27 27 CD cord-335975-m6lkrehi 3977 5 ( ( -LRB- cord-335975-m6lkrehi 3977 6 34.6 34.6 CD cord-335975-m6lkrehi 3977 7 % % NN cord-335975-m6lkrehi 3977 8 ) ) -RRB- cord-335975-m6lkrehi 3977 9 patients patient NNS cord-335975-m6lkrehi 3977 10 , , , cord-335975-m6lkrehi 3977 11 mainly mainly RB cord-335975-m6lkrehi 3977 12 delirium delirium NNP cord-335975-m6lkrehi 3977 13 ( ( -LRB- cord-335975-m6lkrehi 3977 14 n n NN cord-335975-m6lkrehi 3977 15 = = SYM cord-335975-m6lkrehi 3977 16 23 23 CD cord-335975-m6lkrehi 3977 17 , , , cord-335975-m6lkrehi 3977 18 29.4 29.4 CD cord-335975-m6lkrehi 3977 19 % % NN cord-335975-m6lkrehi 3977 20 ) ) -RRB- cord-335975-m6lkrehi 3977 21 . . . cord-335975-m6lkrehi 3978 1 Digestive digestive JJ cord-335975-m6lkrehi 3978 2 events event NNS cord-335975-m6lkrehi 3978 3 occurred occur VBD cord-335975-m6lkrehi 3978 4 in in IN cord-335975-m6lkrehi 3978 5 29 29 CD cord-335975-m6lkrehi 3978 6 ( ( -LRB- cord-335975-m6lkrehi 3978 7 37.1 37.1 CD cord-335975-m6lkrehi 3978 8 % % NN cord-335975-m6lkrehi 3978 9 ) ) -RRB- cord-335975-m6lkrehi 3978 10 patients patient NNS cord-335975-m6lkrehi 3978 11 . . . cord-335975-m6lkrehi 3979 1 Cardiovascular cardiovascular JJ cord-335975-m6lkrehi 3979 2 events event NNS cord-335975-m6lkrehi 3979 3 concerned concern VBD cord-335975-m6lkrehi 3979 4 49 49 CD cord-335975-m6lkrehi 3979 5 ( ( -LRB- cord-335975-m6lkrehi 3979 6 63 63 CD cord-335975-m6lkrehi 3979 7 % % NN cord-335975-m6lkrehi 3979 8 ) ) -RRB- cord-335975-m6lkrehi 3979 9 patients patient NNS cord-335975-m6lkrehi 3979 10 and and CC cord-335975-m6lkrehi 3979 11 consisted consist VBD cord-335975-m6lkrehi 3979 12 in in IN cord-335975-m6lkrehi 3979 13 de de NNP cord-335975-m6lkrehi 3979 14 novo novo NNP cord-335975-m6lkrehi 3979 15 hypertension hypertension NN cord-335975-m6lkrehi 3979 16 in in IN cord-335975-m6lkrehi 3979 17 18 18 CD cord-335975-m6lkrehi 3979 18 ( ( -LRB- cord-335975-m6lkrehi 3979 19 23 23 CD cord-335975-m6lkrehi 3979 20 % % NN cord-335975-m6lkrehi 3979 21 ) ) -RRB- cord-335975-m6lkrehi 3979 22 patients patient NNS cord-335975-m6lkrehi 3979 23 , , , cord-335975-m6lkrehi 3979 24 and and CC cord-335975-m6lkrehi 3979 25 EKG EKG NNP cord-335975-m6lkrehi 3979 26 disturbances disturbance NNS cord-335975-m6lkrehi 3979 27 in in IN cord-335975-m6lkrehi 3979 28 24 24 CD cord-335975-m6lkrehi 3979 29 ( ( -LRB- cord-335975-m6lkrehi 3979 30 30 30 CD cord-335975-m6lkrehi 3979 31 % % NN cord-335975-m6lkrehi 3979 32 ) ) -RRB- cord-335975-m6lkrehi 3979 33 patients patient NNS cord-335975-m6lkrehi 3979 34 . . . cord-335975-m6lkrehi 3980 1 During during IN cord-335975-m6lkrehi 3980 2 ICU ICU NNP cord-335975-m6lkrehi 3980 3 stay stay NN cord-335975-m6lkrehi 3980 4 , , , cord-335975-m6lkrehi 3980 5 9 9 CD cord-335975-m6lkrehi 3980 6 ( ( -LRB- cord-335975-m6lkrehi 3980 7 11.5 11.5 CD cord-335975-m6lkrehi 3980 8 % % NN cord-335975-m6lkrehi 3980 9 ) ) -RRB- cord-335975-m6lkrehi 3980 10 patients patient NNS cord-335975-m6lkrehi 3980 11 required require VBD cord-335975-m6lkrehi 3980 12 mechanical mechanical JJ cord-335975-m6lkrehi 3980 13 ventilation ventilation NN cord-335975-m6lkrehi 3980 14 and and CC cord-335975-m6lkrehi 3980 15 6 6 CD cord-335975-m6lkrehi 3980 16 ( ( -LRB- cord-335975-m6lkrehi 3980 17 7.6 7.6 CD cord-335975-m6lkrehi 3980 18 % % NN cord-335975-m6lkrehi 3980 19 ) ) -RRB- cord-335975-m6lkrehi 3980 20 patients patient NNS cord-335975-m6lkrehi 3980 21 required require VBD cord-335975-m6lkrehi 3980 22 vasopressors vasopressor NNS cord-335975-m6lkrehi 3980 23 . . . cord-335975-m6lkrehi 3981 1 Volume volume NN cord-335975-m6lkrehi 3981 2 resuscitation resuscitation NN cord-335975-m6lkrehi 3981 3 with with IN cord-335975-m6lkrehi 3981 4 crystalloids crystalloids NNP cord-335975-m6lkrehi 3981 5 was be VBD cord-335975-m6lkrehi 3981 6 the the DT cord-335975-m6lkrehi 3981 7 first first JJ cord-335975-m6lkrehi 3981 8 treatment treatment NN cord-335975-m6lkrehi 3981 9 in in IN cord-335975-m6lkrehi 3981 10 73 73 CD cord-335975-m6lkrehi 3981 11 ( ( -LRB- cord-335975-m6lkrehi 3981 12 93.5 93.5 CD cord-335975-m6lkrehi 3981 13 % % NN cord-335975-m6lkrehi 3981 14 ) ) -RRB- cord-335975-m6lkrehi 3981 15 patients patient NNS cord-335975-m6lkrehi 3981 16 , , , cord-335975-m6lkrehi 3981 17 63 63 CD cord-335975-m6lkrehi 3981 18 ( ( -LRB- cord-335975-m6lkrehi 3981 19 80.7 80.7 CD cord-335975-m6lkrehi 3981 20 % % NN cord-335975-m6lkrehi 3981 21 ) ) -RRB- cord-335975-m6lkrehi 3981 22 received receive VBD cord-335975-m6lkrehi 3981 23 bisphosphonates bisphosphonate NNS cord-335975-m6lkrehi 3981 24 and and CC cord-335975-m6lkrehi 3981 25 48 48 CD cord-335975-m6lkrehi 3981 26 ( ( -LRB- cord-335975-m6lkrehi 3981 27 61.5 61.5 CD cord-335975-m6lkrehi 3981 28 % % NN cord-335975-m6lkrehi 3981 29 ) ) -RRB- cord-335975-m6lkrehi 3981 30 received receive VBD cord-335975-m6lkrehi 3981 31 corticosteroids corticosteroid NNS cord-335975-m6lkrehi 3981 32 . . . cord-335975-m6lkrehi 3982 1 Respective respective JJ cord-335975-m6lkrehi 3982 2 ICU ICU NNP cord-335975-m6lkrehi 3982 3 and and CC cord-335975-m6lkrehi 3982 4 hospital hospital NN cord-335975-m6lkrehi 3982 5 mortality mortality NN cord-335975-m6lkrehi 3982 6 were be VBD cord-335975-m6lkrehi 3982 7 11.5 11.5 CD cord-335975-m6lkrehi 3982 8 and and CC cord-335975-m6lkrehi 3982 9 21.7 21.7 CD cord-335975-m6lkrehi 3982 10 % % NN cord-335975-m6lkrehi 3982 11 . . . cord-335975-m6lkrehi 3983 1 There there EX cord-335975-m6lkrehi 3983 2 was be VBD cord-335975-m6lkrehi 3983 3 no no DT cord-335975-m6lkrehi 3983 4 correlation correlation NN cord-335975-m6lkrehi 3983 5 between between IN cord-335975-m6lkrehi 3983 6 the the DT cord-335975-m6lkrehi 3983 7 degree degree NN cord-335975-m6lkrehi 3983 8 of of IN cord-335975-m6lkrehi 3983 9 HCM HCM NNP cord-335975-m6lkrehi 3983 10 and and CC cord-335975-m6lkrehi 3983 11 ICU ICU NNP cord-335975-m6lkrehi 3983 12 mortality mortality NN cord-335975-m6lkrehi 3983 13 ( ( -LRB- cord-335975-m6lkrehi 3983 14 p p NN cord-335975-m6lkrehi 3983 15 = = SYM cord-335975-m6lkrehi 3983 16 0.1 0.1 CD cord-335975-m6lkrehi 3983 17 ) ) -RRB- cord-335975-m6lkrehi 3983 18 . . . cord-335975-m6lkrehi 3984 1 ICU ICU NNP cord-335975-m6lkrehi 3984 2 and and CC cord-335975-m6lkrehi 3984 3 hospital hospital NN cord-335975-m6lkrehi 3984 4 mortality mortality NN cord-335975-m6lkrehi 3984 5 were be VBD cord-335975-m6lkrehi 3984 6 associated associate VBN cord-335975-m6lkrehi 3984 7 with with IN cord-335975-m6lkrehi 3984 8 the the DT cord-335975-m6lkrehi 3984 9 underlying underlie VBG cord-335975-m6lkrehi 3984 10 disease disease NN cord-335975-m6lkrehi 3984 11 ( ( -LRB- cord-335975-m6lkrehi 3984 12 hematological hematological JJ cord-335975-m6lkrehi 3984 13 malignancies malignancy NNS cord-335975-m6lkrehi 3984 14 ( ( -LRB- cord-335975-m6lkrehi 3984 15 p p NN cord-335975-m6lkrehi 3984 16 = = SYM cord-335975-m6lkrehi 3984 17 0.04 0.04 CD cord-335975-m6lkrehi 3984 18 ) ) -RRB- cord-335975-m6lkrehi 3984 19 ) ) -RRB- cord-335975-m6lkrehi 3984 20 . . . cord-335975-m6lkrehi 3985 1 Conclusion conclusion NN cord-335975-m6lkrehi 3985 2 : : : cord-335975-m6lkrehi 3985 3 HCM HCM NNP cord-335975-m6lkrehi 3985 4 is be VBZ cord-335975-m6lkrehi 3985 5 associated associate VBN cord-335975-m6lkrehi 3985 6 with with IN cord-335975-m6lkrehi 3985 7 high high JJ cord-335975-m6lkrehi 3985 8 mortality mortality NN cord-335975-m6lkrehi 3985 9 rates rate NNS cord-335975-m6lkrehi 3985 10 . . . cord-335975-m6lkrehi 3986 1 The the DT cord-335975-m6lkrehi 3986 2 increased increased JJ cord-335975-m6lkrehi 3986 3 mortality mortality NN cord-335975-m6lkrehi 3986 4 is be VBZ cord-335975-m6lkrehi 3986 5 a a DT cord-335975-m6lkrehi 3986 6 consequence consequence NN cord-335975-m6lkrehi 3986 7 of of IN cord-335975-m6lkrehi 3986 8 the the DT cord-335975-m6lkrehi 3986 9 main main JJ cord-335975-m6lkrehi 3986 10 mechanism mechanism NN cord-335975-m6lkrehi 3986 11 , , , cord-335975-m6lkrehi 3986 12 mainly mainly RB cord-335975-m6lkrehi 3986 13 underlying underlie VBG cord-335975-m6lkrehi 3986 14 malignancy malignancy NN cord-335975-m6lkrehi 3986 15 rather rather RB cord-335975-m6lkrehi 3986 16 than than IN cord-335975-m6lkrehi 3986 17 HCM HCM NNP cord-335975-m6lkrehi 3986 18 per per FW cord-335975-m6lkrehi 3986 19 se se FW cord-335975-m6lkrehi 3986 20 . . . cord-335975-m6lkrehi 3987 1 The the DT cord-335975-m6lkrehi 3987 2 course course NN cord-335975-m6lkrehi 3987 3 of of IN cord-335975-m6lkrehi 3987 4 HCM HCM NNP cord-335975-m6lkrehi 3987 5 may may MD cord-335975-m6lkrehi 3987 6 be be VB cord-335975-m6lkrehi 3987 7 complicated complicate VBN cord-335975-m6lkrehi 3987 8 by by IN cord-335975-m6lkrehi 3987 9 organ organ NN cord-335975-m6lkrehi 3987 10 failures failure NNS cord-335975-m6lkrehi 3987 11 that that WDT cord-335975-m6lkrehi 3987 12 are be VBP cord-335975-m6lkrehi 3987 13 most most JJS cord-335975-m6lkrehi 3987 14 of of IN cord-335975-m6lkrehi 3987 15 the the DT cord-335975-m6lkrehi 3987 16 time time NN cord-335975-m6lkrehi 3987 17 reversible reversible JJ cord-335975-m6lkrehi 3987 18 with with IN cord-335975-m6lkrehi 3987 19 early early JJ cord-335975-m6lkrehi 3987 20 ICU ICU NNP cord-335975-m6lkrehi 3987 21 management management NN cord-335975-m6lkrehi 3987 22 . . . cord-335975-m6lkrehi 3988 1 Introduction introduction NN cord-335975-m6lkrehi 3988 2 : : : cord-335975-m6lkrehi 3989 1 Sepsis sepsis NN cord-335975-m6lkrehi 3989 2 is be VBZ cord-335975-m6lkrehi 3989 3 one one CD cord-335975-m6lkrehi 3989 4 of of IN cord-335975-m6lkrehi 3989 5 the the DT cord-335975-m6lkrehi 3989 6 leading leading JJ cord-335975-m6lkrehi 3989 7 cause cause NN cord-335975-m6lkrehi 3989 8 of of IN cord-335975-m6lkrehi 3989 9 death death NN cord-335975-m6lkrehi 3989 10 among among IN cord-335975-m6lkrehi 3989 11 patients patient NNS cord-335975-m6lkrehi 3989 12 with with IN cord-335975-m6lkrehi 3989 13 chronic chronic JJ cord-335975-m6lkrehi 3989 14 kidney kidney NN cord-335975-m6lkrehi 3989 15 disease disease NN cord-335975-m6lkrehi 3989 16 ( ( -LRB- cord-335975-m6lkrehi 3989 17 CKD CKD NNP cord-335975-m6lkrehi 3989 18 ) ) -RRB- cord-335975-m6lkrehi 3989 19 . . . cord-335975-m6lkrehi 3990 1 The the DT cord-335975-m6lkrehi 3990 2 mechanisms mechanism NNS cord-335975-m6lkrehi 3990 3 of of IN cord-335975-m6lkrehi 3990 4 this this DT cord-335975-m6lkrehi 3990 5 higher high JJR cord-335975-m6lkrehi 3990 6 mortality mortality NN cord-335975-m6lkrehi 3990 7 remain remain VBP cord-335975-m6lkrehi 3990 8 poorly poorly RB cord-335975-m6lkrehi 3990 9 understood understand VBN cord-335975-m6lkrehi 3990 10 . . . cord-335975-m6lkrehi 3991 1 Sepsis sepsis NN cord-335975-m6lkrehi 3991 2 and and CC cord-335975-m6lkrehi 3991 3 chronic chronic JJ cord-335975-m6lkrehi 3991 4 kidney kidney NN cord-335975-m6lkrehi 3991 5 disease disease NN cord-335975-m6lkrehi 3991 6 are be VBP cord-335975-m6lkrehi 3991 7 both both DT cord-335975-m6lkrehi 3991 8 conditions condition NNS cord-335975-m6lkrehi 3991 9 associated associate VBN cord-335975-m6lkrehi 3991 10 with with IN cord-335975-m6lkrehi 3991 11 a a DT cord-335975-m6lkrehi 3991 12 higher high JJR cord-335975-m6lkrehi 3991 13 plasmatic plasmatic JJ cord-335975-m6lkrehi 3991 14 concentration concentration NN cord-335975-m6lkrehi 3991 15 of of IN cord-335975-m6lkrehi 3991 16 bile bile NN cord-335975-m6lkrehi 3991 17 acids acid NNS cord-335975-m6lkrehi 3991 18 . . . cord-335975-m6lkrehi 3992 1 The the DT cord-335975-m6lkrehi 3992 2 Farnesoid Farnesoid NNP cord-335975-m6lkrehi 3992 3 X x NN cord-335975-m6lkrehi 3992 4 receptor receptor NN cord-335975-m6lkrehi 3992 5 ( ( -LRB- cord-335975-m6lkrehi 3992 6 FXR FXR NNP cord-335975-m6lkrehi 3992 7 ) ) -RRB- cord-335975-m6lkrehi 3992 8 is be VBZ cord-335975-m6lkrehi 3992 9 a a DT cord-335975-m6lkrehi 3992 10 key key JJ cord-335975-m6lkrehi 3992 11 regulator regulator NN cord-335975-m6lkrehi 3992 12 of of IN cord-335975-m6lkrehi 3992 13 the the DT cord-335975-m6lkrehi 3992 14 bile bile NN cord-335975-m6lkrehi 3992 15 acid acid NN cord-335975-m6lkrehi 3992 16 metabolism metabolism NN cord-335975-m6lkrehi 3992 17 and and CC cord-335975-m6lkrehi 3992 18 has have VBZ cord-335975-m6lkrehi 3992 19 recently recently RB cord-335975-m6lkrehi 3992 20 been be VBN cord-335975-m6lkrehi 3992 21 involved involve VBN cord-335975-m6lkrehi 3992 22 in in IN cord-335975-m6lkrehi 3992 23 the the DT cord-335975-m6lkrehi 3992 24 regulation regulation NN cord-335975-m6lkrehi 3992 25 of of IN cord-335975-m6lkrehi 3992 26 the the DT cord-335975-m6lkrehi 3992 27 inflammasome inflammasome NN cord-335975-m6lkrehi 3992 28 during during IN cord-335975-m6lkrehi 3992 29 sepsis sepsis NN cord-335975-m6lkrehi 3992 30 . . . cord-335975-m6lkrehi 3993 1 We -PRON- PRP cord-335975-m6lkrehi 3993 2 explored explore VBD cord-335975-m6lkrehi 3993 3 the the DT cord-335975-m6lkrehi 3993 4 role role NN cord-335975-m6lkrehi 3993 5 of of IN cord-335975-m6lkrehi 3993 6 FXR FXR NNP cord-335975-m6lkrehi 3993 7 in in IN cord-335975-m6lkrehi 3993 8 the the DT cord-335975-m6lkrehi 3993 9 prognostic prognostic NN cord-335975-m6lkrehi 3993 10 of of IN cord-335975-m6lkrehi 3993 11 sepsis sepsis NN cord-335975-m6lkrehi 3993 12 in in IN cord-335975-m6lkrehi 3993 13 an an DT cord-335975-m6lkrehi 3993 14 animal animal NN cord-335975-m6lkrehi 3993 15 model model NN cord-335975-m6lkrehi 3993 16 of of IN cord-335975-m6lkrehi 3993 17 CKD CKD NNP cord-335975-m6lkrehi 3993 18 . . . cord-335975-m6lkrehi 3994 1 Patients patient NNS cord-335975-m6lkrehi 3994 2 and and CC cord-335975-m6lkrehi 3994 3 methods method NNS cord-335975-m6lkrehi 3994 4 : : : cord-335975-m6lkrehi 3994 5 Sepsis sepsis NN cord-335975-m6lkrehi 3994 6 was be VBD cord-335975-m6lkrehi 3994 7 provoked provoke VBN cord-335975-m6lkrehi 3994 8 by by IN cord-335975-m6lkrehi 3994 9 the the DT cord-335975-m6lkrehi 3994 10 injection injection NN cord-335975-m6lkrehi 3994 11 of of IN cord-335975-m6lkrehi 3994 12 0.5 0.5 CD cord-335975-m6lkrehi 3994 13 mg mg NNP cord-335975-m6lkrehi 3994 14 kg kg NNS cord-335975-m6lkrehi 3994 15 of of IN cord-335975-m6lkrehi 3994 16 LPS LPS NNP cord-335975-m6lkrehi 3994 17 6 6 CD cord-335975-m6lkrehi 3994 18 weeks week NNS cord-335975-m6lkrehi 3994 19 after after IN cord-335975-m6lkrehi 3994 20 the the DT cord-335975-m6lkrehi 3994 21 creation creation NN cord-335975-m6lkrehi 3994 22 of of IN cord-335975-m6lkrehi 3994 23 CKD CKD NNP cord-335975-m6lkrehi 3994 24 . . . cord-335975-m6lkrehi 3995 1 The the DT cord-335975-m6lkrehi 3995 2 CKD CKD NNP cord-335975-m6lkrehi 3995 3 was be VBD cord-335975-m6lkrehi 3995 4 created create VBN cord-335975-m6lkrehi 3995 5 by by IN cord-335975-m6lkrehi 3995 6 unilateral unilateral JJ cord-335975-m6lkrehi 3995 7 nephrectomy nephrectomy NN cord-335975-m6lkrehi 3995 8 associated associate VBN cord-335975-m6lkrehi 3995 9 with with IN cord-335975-m6lkrehi 3995 10 contralateral contralateral JJ cord-335975-m6lkrehi 3995 11 thermocauterisation thermocauterisation NN cord-335975-m6lkrehi 3995 12 . . . cord-335975-m6lkrehi 3996 1 The the DT cord-335975-m6lkrehi 3996 2 mice mouse NNS cord-335975-m6lkrehi 3996 3 ( ( -LRB- cord-335975-m6lkrehi 3996 4 C57BL6 C57BL6 NNP cord-335975-m6lkrehi 3996 5 J J NNP cord-335975-m6lkrehi 3996 6 ) ) -RRB- cord-335975-m6lkrehi 3996 7 were be VBD cord-335975-m6lkrehi 3996 8 randomly randomly RB cord-335975-m6lkrehi 3996 9 assigned assign VBN cord-335975-m6lkrehi 3996 10 to to IN cord-335975-m6lkrehi 3996 11 one one CD cord-335975-m6lkrehi 3996 12 of of IN cord-335975-m6lkrehi 3996 13 the the DT cord-335975-m6lkrehi 3996 14 following follow VBG cord-335975-m6lkrehi 3996 15 groups group NNS cord-335975-m6lkrehi 3996 16 - - HYPH cord-335975-m6lkrehi 3996 17 sham sham JJ cord-335975-m6lkrehi 3996 18 placebo placebo NN cord-335975-m6lkrehi 3996 19 , , , cord-335975-m6lkrehi 3996 20 CKD CKD NNP cord-335975-m6lkrehi 3996 21 placebo placebo NN cord-335975-m6lkrehi 3996 22 , , , cord-335975-m6lkrehi 3996 23 sham sham JJ cord-335975-m6lkrehi 3996 24 LPS LPS NNP cord-335975-m6lkrehi 3996 25 or or CC cord-335975-m6lkrehi 3996 26 CKD CKD NNP cord-335975-m6lkrehi 3996 27 LPS LPS NNP cord-335975-m6lkrehi 3996 28 . . . cord-335975-m6lkrehi 3997 1 A a DT cord-335975-m6lkrehi 3997 2 fifth fifth JJ cord-335975-m6lkrehi 3997 3 group group NN cord-335975-m6lkrehi 3997 4 of of IN cord-335975-m6lkrehi 3997 5 CKD CKD NNP cord-335975-m6lkrehi 3997 6 LPS LPS NNP cord-335975-m6lkrehi 3997 7 mice mouse NNS cord-335975-m6lkrehi 3997 8 received receive VBD cord-335975-m6lkrehi 3997 9 a a DT cord-335975-m6lkrehi 3997 10 treatment treatment NN cord-335975-m6lkrehi 3997 11 with with IN cord-335975-m6lkrehi 3997 12 sevelamer sevelamer NNP cord-335975-m6lkrehi 3997 13 ( ( -LRB- cord-335975-m6lkrehi 3997 14 a a DT cord-335975-m6lkrehi 3997 15 bile bile NN cord-335975-m6lkrehi 3997 16 acid acid NN cord-335975-m6lkrehi 3997 17 sequestrant sequestrant NN cord-335975-m6lkrehi 3997 18 ) ) -RRB- cord-335975-m6lkrehi 3997 19 during during IN cord-335975-m6lkrehi 3997 20 6 6 CD cord-335975-m6lkrehi 3997 21 weeks week NNS cord-335975-m6lkrehi 3997 22 . . . cord-335975-m6lkrehi 3998 1 Survival survival NN cord-335975-m6lkrehi 3998 2 of of IN cord-335975-m6lkrehi 3998 3 the the DT cord-335975-m6lkrehi 3998 4 animals animal NNS cord-335975-m6lkrehi 3998 5 , , , cord-335975-m6lkrehi 3998 6 serum serum NN cord-335975-m6lkrehi 3998 7 biochemistry biochemistry NN cord-335975-m6lkrehi 3998 8 and and CC cord-335975-m6lkrehi 3998 9 molecular molecular JJ cord-335975-m6lkrehi 3998 10 biology biology NN cord-335975-m6lkrehi 3998 11 in in IN cord-335975-m6lkrehi 3998 12 the the DT cord-335975-m6lkrehi 3998 13 kidney kidney NN cord-335975-m6lkrehi 3998 14 were be VBD cord-335975-m6lkrehi 3998 15 performed perform VBN cord-335975-m6lkrehi 3998 16 after after IN cord-335975-m6lkrehi 3998 17 sacrifice sacrifice NN cord-335975-m6lkrehi 3998 18 . . . cord-335975-m6lkrehi 3999 1 Results result NNS cord-335975-m6lkrehi 3999 2 : : : cord-335975-m6lkrehi 4000 1 Whereas whereas IN cord-335975-m6lkrehi 4000 2 the the DT cord-335975-m6lkrehi 4000 3 sham sham JJ cord-335975-m6lkrehi 4000 4 LPS lp NNS cord-335975-m6lkrehi 4000 5 animals animal NNS cord-335975-m6lkrehi 4000 6 survived survive VBD cord-335975-m6lkrehi 4000 7 , , , cord-335975-m6lkrehi 4000 8 all all DT cord-335975-m6lkrehi 4000 9 CKD CKD NNP cord-335975-m6lkrehi 4000 10 LPS LPS NNP cord-335975-m6lkrehi 4000 11 animals animal NNS cord-335975-m6lkrehi 4000 12 died die VBD cord-335975-m6lkrehi 4000 13 during during IN cord-335975-m6lkrehi 4000 14 the the DT cord-335975-m6lkrehi 4000 15 72 72 CD cord-335975-m6lkrehi 4000 16 h h NN cord-335975-m6lkrehi 4000 17 following follow VBG cord-335975-m6lkrehi 4000 18 the the DT cord-335975-m6lkrehi 4000 19 injection injection NN cord-335975-m6lkrehi 4000 20 of of IN cord-335975-m6lkrehi 4000 21 LPS LPS NNP cord-335975-m6lkrehi 4000 22 . . . cord-335975-m6lkrehi 4001 1 The the DT cord-335975-m6lkrehi 4001 2 plasmatic plasmatic JJ cord-335975-m6lkrehi 4001 3 urea urea NN cord-335975-m6lkrehi 4001 4 , , , cord-335975-m6lkrehi 4001 5 IL1beta IL1beta NNP cord-335975-m6lkrehi 4001 6 and and CC cord-335975-m6lkrehi 4001 7 TNFa TNFa NNP cord-335975-m6lkrehi 4001 8 concentrations concentration NNS cord-335975-m6lkrehi 4001 9 increased increase VBD cord-335975-m6lkrehi 4001 10 with with IN cord-335975-m6lkrehi 4001 11 the the DT cord-335975-m6lkrehi 4001 12 creation creation NN cord-335975-m6lkrehi 4001 13 of of IN cord-335975-m6lkrehi 4001 14 CKD CKD NNP cord-335975-m6lkrehi 4001 15 ( ( -LRB- cord-335975-m6lkrehi 4001 16 CKD CKD NNP cord-335975-m6lkrehi 4001 17 placebo placebo NN cord-335975-m6lkrehi 4001 18 versus versus IN cord-335975-m6lkrehi 4001 19 sham sham JJ cord-335975-m6lkrehi 4001 20 placebo placebo NN cord-335975-m6lkrehi 4001 21 animals animal NNS cord-335975-m6lkrehi 4001 22 ) ) -RRB- cord-335975-m6lkrehi 4001 23 and and CC cord-335975-m6lkrehi 4001 24 with with IN cord-335975-m6lkrehi 4001 25 the the DT cord-335975-m6lkrehi 4001 26 creation creation NN cord-335975-m6lkrehi 4001 27 of of IN cord-335975-m6lkrehi 4001 28 sepsis sepsis NN cord-335975-m6lkrehi 4001 29 ( ( -LRB- cord-335975-m6lkrehi 4001 30 CKD CKD NNP cord-335975-m6lkrehi 4001 31 LPS LPS NNP cord-335975-m6lkrehi 4001 32 versus versus IN cord-335975-m6lkrehi 4001 33 sham sham JJ cord-335975-m6lkrehi 4001 34 LPS LPS NNP cord-335975-m6lkrehi 4001 35 groups group NNS cord-335975-m6lkrehi 4001 36 ) ) -RRB- cord-335975-m6lkrehi 4001 37 . . . cord-335975-m6lkrehi 4002 1 Whereas whereas IN cord-335975-m6lkrehi 4002 2 the the DT cord-335975-m6lkrehi 4002 3 expression expression NN cord-335975-m6lkrehi 4002 4 of of IN cord-335975-m6lkrehi 4002 5 FXR FXR NNP cord-335975-m6lkrehi 4002 6 RNA RNA NNP cord-335975-m6lkrehi 4002 7 did do VBD cord-335975-m6lkrehi 4002 8 not not RB cord-335975-m6lkrehi 4002 9 changed change VBN cord-335975-m6lkrehi 4002 10 with with IN cord-335975-m6lkrehi 4002 11 the the DT cord-335975-m6lkrehi 4002 12 injection injection NN cord-335975-m6lkrehi 4002 13 of of IN cord-335975-m6lkrehi 4002 14 LPS LPS NNP cord-335975-m6lkrehi 4002 15 in in IN cord-335975-m6lkrehi 4002 16 the the DT cord-335975-m6lkrehi 4002 17 sham sham NN cord-335975-m6lkrehi 4002 18 animals animal NNS cord-335975-m6lkrehi 4002 19 ( ( -LRB- cord-335975-m6lkrehi 4002 20 sham sham JJ cord-335975-m6lkrehi 4002 21 LPS LPS NNP cord-335975-m6lkrehi 4002 22 versus versus IN cord-335975-m6lkrehi 4002 23 sham sham JJ cord-335975-m6lkrehi 4002 24 placebo placebo NN cord-335975-m6lkrehi 4002 25 ) ) -RRB- cord-335975-m6lkrehi 4002 26 , , , cord-335975-m6lkrehi 4002 27 the the DT cord-335975-m6lkrehi 4002 28 FXR FXR NNP cord-335975-m6lkrehi 4002 29 RNA RNA NNP cord-335975-m6lkrehi 4002 30 decreased decrease VBD cord-335975-m6lkrehi 4002 31 with with IN cord-335975-m6lkrehi 4002 32 the the DT cord-335975-m6lkrehi 4002 33 creation creation NN cord-335975-m6lkrehi 4002 34 of of IN cord-335975-m6lkrehi 4002 35 sepsis sepsis NN cord-335975-m6lkrehi 4002 36 in in IN cord-335975-m6lkrehi 4002 37 the the DT cord-335975-m6lkrehi 4002 38 CKD CKD NNP cord-335975-m6lkrehi 4002 39 animals animal NNS cord-335975-m6lkrehi 4002 40 ( ( -LRB- cord-335975-m6lkrehi 4002 41 CKD CKD NNP cord-335975-m6lkrehi 4002 42 LPS LPS NNP cord-335975-m6lkrehi 4002 43 versus versus IN cord-335975-m6lkrehi 4002 44 CKD CKD NNP cord-335975-m6lkrehi 4002 45 placebo placebo NN cord-335975-m6lkrehi 4002 46 groups group NNS cord-335975-m6lkrehi 4002 47 ) ) -RRB- cord-335975-m6lkrehi 4002 48 . . . cord-335975-m6lkrehi 4003 1 The the DT cord-335975-m6lkrehi 4003 2 CKD CKD NNP cord-335975-m6lkrehi 4003 3 animals animal NNS cord-335975-m6lkrehi 4003 4 treated treat VBN cord-335975-m6lkrehi 4003 5 with with IN cord-335975-m6lkrehi 4003 6 sevelamer sevelamer NN cord-335975-m6lkrehi 4003 7 6 6 CD cord-335975-m6lkrehi 4003 8 weeks week NNS cord-335975-m6lkrehi 4003 9 before before IN cord-335975-m6lkrehi 4003 10 the the DT cord-335975-m6lkrehi 4003 11 administration administration NN cord-335975-m6lkrehi 4003 12 of of IN cord-335975-m6lkrehi 4003 13 LPS LPS NNP cord-335975-m6lkrehi 4003 14 ( ( -LRB- cord-335975-m6lkrehi 4003 15 CKD CKD NNP cord-335975-m6lkrehi 4003 16 sev sev NNP cord-335975-m6lkrehi 4003 17 LPS LPS NNP cord-335975-m6lkrehi 4003 18 group group NN cord-335975-m6lkrehi 4003 19 ) ) -RRB- cord-335975-m6lkrehi 4003 20 had have VBD cord-335975-m6lkrehi 4003 21 a a DT cord-335975-m6lkrehi 4003 22 lower low JJR cord-335975-m6lkrehi 4003 23 plasmatic plasmatic JJ cord-335975-m6lkrehi 4003 24 concentration concentration NN cord-335975-m6lkrehi 4003 25 of of IN cord-335975-m6lkrehi 4003 26 Il1b Il1b NNP cord-335975-m6lkrehi 4003 27 , , , cord-335975-m6lkrehi 4003 28 TNFa TNFa NNP cord-335975-m6lkrehi 4003 29 and and CC cord-335975-m6lkrehi 4003 30 increased increase VBD cord-335975-m6lkrehi 4003 31 the the DT cord-335975-m6lkrehi 4003 32 RNA RNA NNP cord-335975-m6lkrehi 4003 33 expression expression NN cord-335975-m6lkrehi 4003 34 of of IN cord-335975-m6lkrehi 4003 35 FXR FXR NNP cord-335975-m6lkrehi 4003 36 in in IN cord-335975-m6lkrehi 4003 37 the the DT cord-335975-m6lkrehi 4003 38 kidney kidney NN cord-335975-m6lkrehi 4003 39 compared compare VBN cord-335975-m6lkrehi 4003 40 to to IN cord-335975-m6lkrehi 4003 41 the the DT cord-335975-m6lkrehi 4003 42 CKD CKD NNP cord-335975-m6lkrehi 4003 43 LPS LPS NNP cord-335975-m6lkrehi 4003 44 group group NN cord-335975-m6lkrehi 4003 45 . . . cord-335975-m6lkrehi 4004 1 Also also RB cord-335975-m6lkrehi 4004 2 , , , cord-335975-m6lkrehi 4004 3 the the DT cord-335975-m6lkrehi 4004 4 treatment treatment NN cord-335975-m6lkrehi 4004 5 with with IN cord-335975-m6lkrehi 4004 6 sevelamer sevelamer NNP cord-335975-m6lkrehi 4004 7 improved improve VBD cord-335975-m6lkrehi 4004 8 the the DT cord-335975-m6lkrehi 4004 9 survival survival NN cord-335975-m6lkrehi 4004 10 of of IN cord-335975-m6lkrehi 4004 11 the the DT cord-335975-m6lkrehi 4004 12 CKD CKD NNP cord-335975-m6lkrehi 4004 13 LPS LPS NNP cord-335975-m6lkrehi 4004 14 animals animal NNS cord-335975-m6lkrehi 4004 15 . . . cord-335975-m6lkrehi 4005 1 Conclusion conclusion NN cord-335975-m6lkrehi 4005 2 : : : cord-335975-m6lkrehi 4005 3 our -PRON- PRP$ cord-335975-m6lkrehi 4005 4 study study NN cord-335975-m6lkrehi 4005 5 demonstrates demonstrate VBZ cord-335975-m6lkrehi 4005 6 a a DT cord-335975-m6lkrehi 4005 7 relation relation NN cord-335975-m6lkrehi 4005 8 between between IN cord-335975-m6lkrehi 4005 9 FXR FXR NNP cord-335975-m6lkrehi 4005 10 and and CC cord-335975-m6lkrehi 4005 11 the the DT cord-335975-m6lkrehi 4005 12 prognostic prognostic NN cord-335975-m6lkrehi 4005 13 of of IN cord-335975-m6lkrehi 4005 14 sepsis sepsis NN cord-335975-m6lkrehi 4005 15 in in IN cord-335975-m6lkrehi 4005 16 CKD CKD NNP cord-335975-m6lkrehi 4005 17 animals animal NNS cord-335975-m6lkrehi 4005 18 . . . cord-335975-m6lkrehi 4006 1 The the DT cord-335975-m6lkrehi 4006 2 exact exact JJ cord-335975-m6lkrehi 4006 3 link link NN cord-335975-m6lkrehi 4006 4 and and CC cord-335975-m6lkrehi 4006 5 the the DT cord-335975-m6lkrehi 4006 6 potential potential JJ cord-335975-m6lkrehi 4006 7 therapeutic therapeutic JJ cord-335975-m6lkrehi 4006 8 interest interest NN cord-335975-m6lkrehi 4006 9 of of IN cord-335975-m6lkrehi 4006 10 targeting target VBG cord-335975-m6lkrehi 4006 11 FXR FXR NNP cord-335975-m6lkrehi 4006 12 and and CC cord-335975-m6lkrehi 4006 13 bile bile NN cord-335975-m6lkrehi 4006 14 acids acid NNS cord-335975-m6lkrehi 4006 15 metabolism metabolism VBP cord-335975-m6lkrehi 4006 16 in in IN cord-335975-m6lkrehi 4006 17 CKD CKD NNP cord-335975-m6lkrehi 4006 18 patients patient NNS cord-335975-m6lkrehi 4006 19 remain remain VBP cord-335975-m6lkrehi 4006 20 to to TO cord-335975-m6lkrehi 4006 21 be be VB cord-335975-m6lkrehi 4006 22 studied study VBN cord-335975-m6lkrehi 4006 23 . . . cord-335975-m6lkrehi 4007 1 Introduction introduction NN cord-335975-m6lkrehi 4007 2 : : : cord-335975-m6lkrehi 4007 3 Dysnatraemia Dysnatraemia NNP cord-335975-m6lkrehi 4007 4 , , , cord-335975-m6lkrehi 4007 5 dyskalaemia dyskalaemia NN cord-335975-m6lkrehi 4007 6 and and CC cord-335975-m6lkrehi 4007 7 hypomagnesemia hypomagnesemia NN cord-335975-m6lkrehi 4007 8 are be VBP cord-335975-m6lkrehi 4007 9 frequent frequent JJ cord-335975-m6lkrehi 4007 10 metabolic metabolic JJ cord-335975-m6lkrehi 4007 11 disorders disorder NNS cord-335975-m6lkrehi 4007 12 in in IN cord-335975-m6lkrehi 4007 13 intensive intensive JJ cord-335975-m6lkrehi 4007 14 care care NN cord-335975-m6lkrehi 4007 15 , , , cord-335975-m6lkrehi 4007 16 and and CC cord-335975-m6lkrehi 4007 17 their -PRON- PRP$ cord-335975-m6lkrehi 4007 18 causes cause NNS cord-335975-m6lkrehi 4007 19 represent represent VBP cord-335975-m6lkrehi 4007 20 a a DT cord-335975-m6lkrehi 4007 21 major major JJ cord-335975-m6lkrehi 4007 22 concern concern NN cord-335975-m6lkrehi 4007 23 for for IN cord-335975-m6lkrehi 4007 24 the the DT cord-335975-m6lkrehi 4007 25 intensivist intensivist NN cord-335975-m6lkrehi 4007 26 , , , cord-335975-m6lkrehi 4007 27 especially especially RB cord-335975-m6lkrehi 4007 28 in in IN cord-335975-m6lkrehi 4007 29 urgent urgent JJ cord-335975-m6lkrehi 4007 30 conditions condition NNS cord-335975-m6lkrehi 4007 31 . . . cord-335975-m6lkrehi 4008 1 In in IN cord-335975-m6lkrehi 4008 2 the the DT cord-335975-m6lkrehi 4008 3 diagnostic diagnostic JJ cord-335975-m6lkrehi 4008 4 approach approach NN cord-335975-m6lkrehi 4008 5 , , , cord-335975-m6lkrehi 4008 6 we -PRON- PRP cord-335975-m6lkrehi 4008 7 often often RB cord-335975-m6lkrehi 4008 8 use use VBP cord-335975-m6lkrehi 4008 9 the the DT cord-335975-m6lkrehi 4008 10 urine urine NN cord-335975-m6lkrehi 4008 11 analysis analysis NN cord-335975-m6lkrehi 4008 12 . . . cord-335975-m6lkrehi 4009 1 Although although IN cord-335975-m6lkrehi 4009 2 measurement measurement NN cord-335975-m6lkrehi 4009 3 of of IN cord-335975-m6lkrehi 4009 4 24-hour 24-hour JJ cord-335975-m6lkrehi 4009 5 urine urine NN cord-335975-m6lkrehi 4009 6 electrolyte electrolyte JJ cord-335975-m6lkrehi 4009 7 excretion excretion NN cord-335975-m6lkrehi 4009 8 ( ( -LRB- cord-335975-m6lkrehi 4009 9 24-HU 24-hu CD cord-335975-m6lkrehi 4009 10 ) ) -RRB- cord-335975-m6lkrehi 4009 11 is be VBZ cord-335975-m6lkrehi 4009 12 considered consider VBN cord-335975-m6lkrehi 4009 13 the the DT cord-335975-m6lkrehi 4009 14 most most RBS cord-335975-m6lkrehi 4009 15 reliable reliable JJ cord-335975-m6lkrehi 4009 16 method method NN cord-335975-m6lkrehi 4009 17 , , , cord-335975-m6lkrehi 4009 18 the the DT cord-335975-m6lkrehi 4009 19 great great JJ cord-335975-m6lkrehi 4009 20 burden burden NN cord-335975-m6lkrehi 4009 21 and and CC cord-335975-m6lkrehi 4009 22 difficulty difficulty NN cord-335975-m6lkrehi 4009 23 in in IN cord-335975-m6lkrehi 4009 24 collecting collect VBG cord-335975-m6lkrehi 4009 25 complete complete JJ cord-335975-m6lkrehi 4009 26 24-hour 24-hour JJ cord-335975-m6lkrehi 4009 27 urine urine NN cord-335975-m6lkrehi 4009 28 has have VBZ cord-335975-m6lkrehi 4009 29 prompted prompt VBN cord-335975-m6lkrehi 4009 30 the the DT cord-335975-m6lkrehi 4009 31 search search NN cord-335975-m6lkrehi 4009 32 for for IN cord-335975-m6lkrehi 4009 33 more more JJR cord-335975-m6lkrehi 4009 34 practical practical JJ cord-335975-m6lkrehi 4009 35 methods method NNS cord-335975-m6lkrehi 4009 36 , , , cord-335975-m6lkrehi 4009 37 such such JJ cord-335975-m6lkrehi 4009 38 as as IN cord-335975-m6lkrehi 4009 39 spot spot NN cord-335975-m6lkrehi 4009 40 urine urine NN cord-335975-m6lkrehi 4009 41 analysis analysis NN cord-335975-m6lkrehi 4009 42 . . . cord-335975-m6lkrehi 4010 1 The the DT cord-335975-m6lkrehi 4010 2 aim aim NN cord-335975-m6lkrehi 4010 3 of of IN cord-335975-m6lkrehi 4010 4 the the DT cord-335975-m6lkrehi 4010 5 present present JJ cord-335975-m6lkrehi 4010 6 study study NN cord-335975-m6lkrehi 4010 7 was be VBD cord-335975-m6lkrehi 4010 8 to to TO cord-335975-m6lkrehi 4010 9 compare compare VB cord-335975-m6lkrehi 4010 10 electrolyte electrolyte JJ cord-335975-m6lkrehi 4010 11 excretion excretion NN cord-335975-m6lkrehi 4010 12 in in IN cord-335975-m6lkrehi 4010 13 urine urine NN cord-335975-m6lkrehi 4010 14 samples sample NNS cord-335975-m6lkrehi 4010 15 collected collect VBN cord-335975-m6lkrehi 4010 16 over over IN cord-335975-m6lkrehi 4010 17 different different JJ cord-335975-m6lkrehi 4010 18 time time NN cord-335975-m6lkrehi 4010 19 periods period NNS cord-335975-m6lkrehi 4010 20 , , , cord-335975-m6lkrehi 4010 21 in in IN cord-335975-m6lkrehi 4010 22 comparison comparison NN cord-335975-m6lkrehi 4010 23 with with IN cord-335975-m6lkrehi 4010 24 a a DT cord-335975-m6lkrehi 4010 25 24-hour 24-hour JJ cord-335975-m6lkrehi 4010 26 urine urine NN cord-335975-m6lkrehi 4010 27 sample sample NN cord-335975-m6lkrehi 4010 28 collection collection NN cord-335975-m6lkrehi 4010 29 considered consider VBN cord-335975-m6lkrehi 4010 30 as as IN cord-335975-m6lkrehi 4010 31 the the DT cord-335975-m6lkrehi 4010 32 gold gold JJ cord-335975-m6lkrehi 4010 33 standard standard JJ cord-335975-m6lkrehi 4010 34 method method NN cord-335975-m6lkrehi 4010 35 . . . cord-335975-m6lkrehi 4011 1 Patients patient NNS cord-335975-m6lkrehi 4011 2 and and CC cord-335975-m6lkrehi 4011 3 methods method NNS cord-335975-m6lkrehi 4011 4 : : : cord-335975-m6lkrehi 4011 5 This this DT cord-335975-m6lkrehi 4011 6 prospective prospective JJ cord-335975-m6lkrehi 4011 7 and and CC cord-335975-m6lkrehi 4011 8 descriptive descriptive JJ cord-335975-m6lkrehi 4011 9 study study NN cord-335975-m6lkrehi 4011 10 included include VBD cord-335975-m6lkrehi 4011 11 30 30 CD cord-335975-m6lkrehi 4011 12 patients patient NNS cord-335975-m6lkrehi 4011 13 admitted admit VBN cord-335975-m6lkrehi 4011 14 in in IN cord-335975-m6lkrehi 4011 15 a a DT cord-335975-m6lkrehi 4011 16 tunisian tunisian JJ cord-335975-m6lkrehi 4011 17 medical medical JJ cord-335975-m6lkrehi 4011 18 ICU ICU NNP cord-335975-m6lkrehi 4011 19 , , , cord-335975-m6lkrehi 4011 20 between between IN cord-335975-m6lkrehi 4011 21 September September NNP cord-335975-m6lkrehi 4011 22 and and CC cord-335975-m6lkrehi 4011 23 December December NNP cord-335975-m6lkrehi 4011 24 2015 2015 CD cord-335975-m6lkrehi 4011 25 . . . cord-335975-m6lkrehi 4012 1 Baseline baseline JJ cord-335975-m6lkrehi 4012 2 characteristics characteristic NNS cord-335975-m6lkrehi 4012 3 , , , cord-335975-m6lkrehi 4012 4 medications medication NNS cord-335975-m6lkrehi 4012 5 and and CC cord-335975-m6lkrehi 4012 6 laboratory laboratory NN cord-335975-m6lkrehi 4012 7 data datum NNS cord-335975-m6lkrehi 4012 8 including include VBG cord-335975-m6lkrehi 4012 9 electrolytes electrolyte NNS cord-335975-m6lkrehi 4012 10 and and CC cord-335975-m6lkrehi 4012 11 renal renal JJ cord-335975-m6lkrehi 4012 12 function function NN cord-335975-m6lkrehi 4012 13 parameters parameter NNS cord-335975-m6lkrehi 4012 14 were be VBD cord-335975-m6lkrehi 4012 15 obtained obtain VBN cord-335975-m6lkrehi 4012 16 from from IN cord-335975-m6lkrehi 4012 17 all all DT cord-335975-m6lkrehi 4012 18 patients patient NNS cord-335975-m6lkrehi 4012 19 . . . cord-335975-m6lkrehi 4013 1 Multiple multiple JJ cord-335975-m6lkrehi 4013 2 urine urine NN cord-335975-m6lkrehi 4013 3 specimens specimen NNS cord-335975-m6lkrehi 4013 4 for for IN cord-335975-m6lkrehi 4013 5 analyzing analyze VBG cord-335975-m6lkrehi 4013 6 Na Na NNP cord-335975-m6lkrehi 4013 7 + + CC cord-335975-m6lkrehi 4013 8 K k NN cord-335975-m6lkrehi 4013 9 + + CC cord-335975-m6lkrehi 4013 10 Mg Mg NNP cord-335975-m6lkrehi 4013 11 + + CC cord-335975-m6lkrehi 4013 12 Urea urea NN cord-335975-m6lkrehi 4014 1 + + CC cord-335975-m6lkrehi 4015 1 Ca ca NN cord-335975-m6lkrehi 4015 2 + + CC cord-335975-m6lkrehi 4015 3 phosphate phosphate NN cord-335975-m6lkrehi 4015 4 + + CC cord-335975-m6lkrehi 4015 5 Creatinine creatinine NN cord-335975-m6lkrehi 4015 6 + + CC cord-335975-m6lkrehi 4015 7 proteins protein NNS cord-335975-m6lkrehi 4015 8 and and CC cord-335975-m6lkrehi 4015 9 uric uric NN cord-335975-m6lkrehi 4015 10 acid acid NN cord-335975-m6lkrehi 4015 11 were be VBD cord-335975-m6lkrehi 4015 12 obtained obtain VBN cord-335975-m6lkrehi 4015 13 from from IN cord-335975-m6lkrehi 4015 14 2-hour 2-hour CD cord-335975-m6lkrehi 4015 15 , , , cord-335975-m6lkrehi 4015 16 12-hour 12-hour CD cord-335975-m6lkrehi 4015 17 and and CC cord-335975-m6lkrehi 4015 18 24-hour 24-hour JJ cord-335975-m6lkrehi 4015 19 urine urine NN cord-335975-m6lkrehi 4015 20 samples sample NNS cord-335975-m6lkrehi 4015 21 during during IN cord-335975-m6lkrehi 4015 22 day day NN cord-335975-m6lkrehi 4015 23 and and CC cord-335975-m6lkrehi 4015 24 night night NN cord-335975-m6lkrehi 4015 25 time time NN cord-335975-m6lkrehi 4015 26 , , , cord-335975-m6lkrehi 4015 27 and and CC cord-335975-m6lkrehi 4015 28 results result NNS cord-335975-m6lkrehi 4015 29 were be VBD cord-335975-m6lkrehi 4015 30 compared compare VBN cord-335975-m6lkrehi 4015 31 with with IN cord-335975-m6lkrehi 4015 32 those those DT cord-335975-m6lkrehi 4015 33 obtained obtain VBN cord-335975-m6lkrehi 4015 34 from from IN cord-335975-m6lkrehi 4015 35 the the DT cord-335975-m6lkrehi 4015 36 gold gold JJ cord-335975-m6lkrehi 4015 37 standard standard JJ cord-335975-m6lkrehi 4015 38 method method NN cord-335975-m6lkrehi 4015 39 ( ( -LRB- cord-335975-m6lkrehi 4015 40 24-hour 24-hour JJ cord-335975-m6lkrehi 4015 41 urine urine NN cord-335975-m6lkrehi 4015 42 collection collection NN cord-335975-m6lkrehi 4015 43 ) ) -RRB- cord-335975-m6lkrehi 4015 44 . . . cord-335975-m6lkrehi 4016 1 Correlation correlation NN cord-335975-m6lkrehi 4016 2 analysis analysis NN cord-335975-m6lkrehi 4016 3 was be VBD cord-335975-m6lkrehi 4016 4 performed perform VBN cord-335975-m6lkrehi 4016 5 using use VBG cord-335975-m6lkrehi 4016 6 the the DT cord-335975-m6lkrehi 4016 7 spearman spearman NN cord-335975-m6lkrehi 4016 8 test test NN cord-335975-m6lkrehi 4016 9 . . . cord-335975-m6lkrehi 4017 1 Results result NNS cord-335975-m6lkrehi 4017 2 : : : cord-335975-m6lkrehi 4018 1 Significant significant JJ cord-335975-m6lkrehi 4018 2 correlation correlation NN cord-335975-m6lkrehi 4018 3 was be VBD cord-335975-m6lkrehi 4018 4 found find VBN cord-335975-m6lkrehi 4018 5 for for IN cord-335975-m6lkrehi 4018 6 all all DT cord-335975-m6lkrehi 4018 7 biochemistry biochemistry NN cord-335975-m6lkrehi 4018 8 parameters parameter NNS cord-335975-m6lkrehi 4018 9 between between IN cord-335975-m6lkrehi 4018 10 24-hour 24-hour JJ cord-335975-m6lkrehi 4018 11 urine urine NN cord-335975-m6lkrehi 4018 12 results result NNS cord-335975-m6lkrehi 4018 13 and and CC cord-335975-m6lkrehi 4018 14 those those DT cord-335975-m6lkrehi 4018 15 obtained obtain VBN cord-335975-m6lkrehi 4018 16 from from IN cord-335975-m6lkrehi 4018 17 2-hour 2-hour CD cord-335975-m6lkrehi 4018 18 and and CC cord-335975-m6lkrehi 4018 19 12-hour 12-hour CD cord-335975-m6lkrehi 4018 20 samples sample NNS cord-335975-m6lkrehi 4018 21 regardless regardless RB cord-335975-m6lkrehi 4018 22 of of IN cord-335975-m6lkrehi 4018 23 day day NN cord-335975-m6lkrehi 4018 24 or or CC cord-335975-m6lkrehi 4018 25 night night NN cord-335975-m6lkrehi 4018 26 sampling sampling NN cord-335975-m6lkrehi 4018 27 . . . cord-335975-m6lkrehi 4019 1 A a DT cord-335975-m6lkrehi 4019 2 comparative comparative JJ cord-335975-m6lkrehi 4019 3 analysis analysis NN cord-335975-m6lkrehi 4019 4 for for IN cord-335975-m6lkrehi 4019 5 sodium sodium NN cord-335975-m6lkrehi 4019 6 and and CC cord-335975-m6lkrehi 4019 7 potassium potassium NN cord-335975-m6lkrehi 4019 8 is be VBZ cord-335975-m6lkrehi 4019 9 shown show VBN cord-335975-m6lkrehi 4019 10 in in IN cord-335975-m6lkrehi 4019 11 Fig Fig NNP cord-335975-m6lkrehi 4019 12 . . . cord-335975-m6lkrehi 4020 1 1 1 LS cord-335975-m6lkrehi 4020 2 . . . cord-335975-m6lkrehi 4021 1 Conclusion conclusion NN cord-335975-m6lkrehi 4021 2 : : : cord-335975-m6lkrehi 4022 1 Determination determination NN cord-335975-m6lkrehi 4022 2 of of IN cord-335975-m6lkrehi 4022 3 electrolyte electrolyte JJ cord-335975-m6lkrehi 4022 4 excretion excretion NN cord-335975-m6lkrehi 4022 5 from from IN cord-335975-m6lkrehi 4022 6 urine urine NN cord-335975-m6lkrehi 4022 7 samples sample NNS cord-335975-m6lkrehi 4022 8 taken take VBN cord-335975-m6lkrehi 4022 9 over over IN cord-335975-m6lkrehi 4022 10 2 2 CD cord-335975-m6lkrehi 4022 11 different different JJ cord-335975-m6lkrehi 4022 12 time time NN cord-335975-m6lkrehi 4022 13 periods period NNS cord-335975-m6lkrehi 4022 14 , , , cord-335975-m6lkrehi 4022 15 2 2 CD cord-335975-m6lkrehi 4022 16 and12 and12 CD cord-335975-m6lkrehi 4022 17 h h NNP cord-335975-m6lkrehi 4022 18 , , , cord-335975-m6lkrehi 4022 19 provides provide VBZ cord-335975-m6lkrehi 4022 20 a a DT cord-335975-m6lkrehi 4022 21 reliable reliable JJ cord-335975-m6lkrehi 4022 22 estimation estimation NN cord-335975-m6lkrehi 4022 23 of of IN cord-335975-m6lkrehi 4022 24 24-hour 24-hour JJ cord-335975-m6lkrehi 4022 25 urine urine NN cord-335975-m6lkrehi 4022 26 electrolyte electrolyte JJ cord-335975-m6lkrehi 4022 27 excretion excretion NN cord-335975-m6lkrehi 4022 28 . . . cord-335975-m6lkrehi 4023 1 It -PRON- PRP cord-335975-m6lkrehi 4023 2 appears appear VBZ cord-335975-m6lkrehi 4023 3 practical practical JJ cord-335975-m6lkrehi 4023 4 for for IN cord-335975-m6lkrehi 4023 5 early early JJ cord-335975-m6lkrehi 4023 6 understanding understanding NN cord-335975-m6lkrehi 4023 7 of of IN cord-335975-m6lkrehi 4023 8 the the DT cord-335975-m6lkrehi 4023 9 mechanism mechanism NN cord-335975-m6lkrehi 4023 10 of of IN cord-335975-m6lkrehi 4023 11 electrolyte electrolyte JJ cord-335975-m6lkrehi 4023 12 imbalance imbalance NN cord-335975-m6lkrehi 4023 13 . . . cord-335975-m6lkrehi 4024 1 However however RB cord-335975-m6lkrehi 4024 2 , , , cord-335975-m6lkrehi 4024 3 further further JJ cord-335975-m6lkrehi 4024 4 studies study NNS cord-335975-m6lkrehi 4024 5 are be VBP cord-335975-m6lkrehi 4024 6 warranted warrant VBN cord-335975-m6lkrehi 4024 7 to to TO cord-335975-m6lkrehi 4024 8 confirm confirm VB cord-335975-m6lkrehi 4024 9 the the DT cord-335975-m6lkrehi 4024 10 usefulness usefulness NN cord-335975-m6lkrehi 4024 11 of of IN cord-335975-m6lkrehi 4024 12 this this DT cord-335975-m6lkrehi 4024 13 approach approach NN cord-335975-m6lkrehi 4024 14 . . . cord-335975-m6lkrehi 4025 1 Use use NN cord-335975-m6lkrehi 4025 2 of of IN cord-335975-m6lkrehi 4025 3 the the DT cord-335975-m6lkrehi 4025 4 procalcitonin procalcitonin JJ cord-335975-m6lkrehi 4025 5 assay assay NN cord-335975-m6lkrehi 4025 6 in in IN cord-335975-m6lkrehi 4025 7 an an DT cord-335975-m6lkrehi 4025 8 adult adult NN cord-335975-m6lkrehi 4025 9 emergencies emergency NNS cord-335975-m6lkrehi 4025 10 department department NN cord-335975-m6lkrehi 4025 11 : : : cord-335975-m6lkrehi 4025 12 retrospective retrospective JJ cord-335975-m6lkrehi 4025 13 experience experience NN cord-335975-m6lkrehi 4025 14 of of IN cord-335975-m6lkrehi 4025 15 a a DT cord-335975-m6lkrehi 4025 16 general general JJ cord-335975-m6lkrehi 4025 17 hospital hospital NN cord-335975-m6lkrehi 4025 18 of of IN cord-335975-m6lkrehi 4025 19 the the DT cord-335975-m6lkrehi 4025 20 suburb suburb NN cord-335975-m6lkrehi 4025 21 of of IN cord-335975-m6lkrehi 4025 22 Paris Paris NNP cord-335975-m6lkrehi 4025 23 ( ( -LRB- cord-335975-m6lkrehi 4025 24 7.85 7.85 CD cord-335975-m6lkrehi 4025 25 - - SYM cord-335975-m6lkrehi 4025 26 13.4 13.4 CD cord-335975-m6lkrehi 4025 27 ) ) -RRB- cord-335975-m6lkrehi 4025 28 . . . cord-335975-m6lkrehi 4026 1 Other other JJ cord-335975-m6lkrehi 4026 2 markers marker NNS cord-335975-m6lkrehi 4026 3 of of IN cord-335975-m6lkrehi 4026 4 infectious infectious JJ cord-335975-m6lkrehi 4026 5 were be VBD cord-335975-m6lkrehi 4026 6 poorly poorly RB cord-335975-m6lkrehi 4026 7 recorded record VBN cord-335975-m6lkrehi 4026 8 ( ( -LRB- cord-335975-m6lkrehi 4026 9 fibrinemia fibrinemia NNP cord-335975-m6lkrehi 4026 10 in34 in34 NNP cord-335975-m6lkrehi 4026 11 ( ( -LRB- cord-335975-m6lkrehi 4026 12 11.5 11.5 CD cord-335975-m6lkrehi 4026 13 % % NN cord-335975-m6lkrehi 4026 14 + + SYM cord-335975-m6lkrehi 4026 15 5.5 5.5 CD cord-335975-m6lkrehi 4026 16 g g NN cord-335975-m6lkrehi 4026 17 L l NN cord-335975-m6lkrehi 4026 18 [ [ -LRB- cord-335975-m6lkrehi 4026 19 4.6 4.6 CD cord-335975-m6lkrehi 4026 20 - - SYM cord-335975-m6lkrehi 4026 21 6.6 6.6 CD cord-335975-m6lkrehi 4026 22 ] ] -RRB- cord-335975-m6lkrehi 4027 1 + + NFP cord-335975-m6lkrehi 4027 2 Immature immature JJ cord-335975-m6lkrehi 4027 3 forms form NNS cord-335975-m6lkrehi 4027 4 on on IN cord-335975-m6lkrehi 4027 5 blood blood NN cord-335975-m6lkrehi 4027 6 count-11.5 count-11.5 NNS cord-335975-m6lkrehi 4027 7 % % NN cord-335975-m6lkrehi 4027 8 ) ) -RRB- cord-335975-m6lkrehi 4027 9 . . . cord-335975-m6lkrehi 4028 1 Only only RB cord-335975-m6lkrehi 4028 2 172 172 CD cord-335975-m6lkrehi 4028 3 ( ( -LRB- cord-335975-m6lkrehi 4028 4 53.6 53.6 CD cord-335975-m6lkrehi 4028 5 % % NN cord-335975-m6lkrehi 4028 6 ) ) -RRB- cord-335975-m6lkrehi 4028 7 had have VBD cord-335975-m6lkrehi 4028 8 blood blood NN cord-335975-m6lkrehi 4028 9 cultures culture NNS cord-335975-m6lkrehi 4028 10 in in IN cord-335975-m6lkrehi 4028 11 the the DT cord-335975-m6lkrehi 4028 12 ED ED NNP cord-335975-m6lkrehi 4028 13 ( ( -LRB- cord-335975-m6lkrehi 4028 14 1 1 CD cord-335975-m6lkrehi 4028 15 patient patient NN cord-335975-m6lkrehi 4028 16 [ [ -LRB- cord-335975-m6lkrehi 4028 17 1 1 CD cord-335975-m6lkrehi 4028 18 ] ] -RRB- cord-335975-m6lkrehi 4028 19 [ [ -LRB- cord-335975-m6lkrehi 4028 20 2 2 CD cord-335975-m6lkrehi 4028 21 ] ] -RRB- cord-335975-m6lkrehi 4028 22 ) ) -RRB- cord-335975-m6lkrehi 4028 23 and and CC cord-335975-m6lkrehi 4028 24 163 163 CD cord-335975-m6lkrehi 4028 25 ( ( -LRB- cord-335975-m6lkrehi 4028 26 50.3 50.3 CD cord-335975-m6lkrehi 4028 27 % % NN cord-335975-m6lkrehi 4028 28 ) ) -RRB- cord-335975-m6lkrehi 4028 29 other(s other(s NNP cord-335975-m6lkrehi 4028 30 ) ) -RRB- cord-335975-m6lkrehi 4028 31 microbiological microbiological JJ cord-335975-m6lkrehi 4028 32 sample(s sample(s NNP cord-335975-m6lkrehi 4028 33 ) ) -RRB- cord-335975-m6lkrehi 4028 34 , , , cord-335975-m6lkrehi 4028 35 mainly mainly RB cord-335975-m6lkrehi 4028 36 urinary urinary JJ cord-335975-m6lkrehi 4028 37 ( ( -LRB- cord-335975-m6lkrehi 4028 38 84 84 CD cord-335975-m6lkrehi 4028 39 patients patient NNS cord-335975-m6lkrehi 4028 40 [ [ -LRB- cord-335975-m6lkrehi 4028 41 25.9 25.9 CD cord-335975-m6lkrehi 4028 42 % % NN cord-335975-m6lkrehi 4028 43 + + CC cord-335975-m6lkrehi 4029 1 among among IN cord-335975-m6lkrehi 4029 2 them -PRON- PRP cord-335975-m6lkrehi 4029 3 33 33 CD cord-335975-m6lkrehi 4029 4 % % NN cord-335975-m6lkrehi 4029 5 considered consider VBN cord-335975-m6lkrehi 4029 6 as as IN cord-335975-m6lkrehi 4029 7 positive positive JJ cord-335975-m6lkrehi 4029 8 ] ] -RRB- cord-335975-m6lkrehi 4029 9 ) ) -RRB- cord-335975-m6lkrehi 4029 10 . . . cord-335975-m6lkrehi 4030 1 5 5 CD cord-335975-m6lkrehi 4030 2 % % NN cord-335975-m6lkrehi 4030 3 of of IN cord-335975-m6lkrehi 4030 4 blood blood NN cord-335975-m6lkrehi 4030 5 cultures culture NNS cord-335975-m6lkrehi 4030 6 were be VBD cord-335975-m6lkrehi 4030 7 positives positive NNS cord-335975-m6lkrehi 4030 8 , , , cord-335975-m6lkrehi 4030 9 mainly mainly RB cord-335975-m6lkrehi 4030 10 for for IN cord-335975-m6lkrehi 4030 11 gram gram NN cord-335975-m6lkrehi 4030 12 negatives negative NNS cord-335975-m6lkrehi 4030 13 ( ( -LRB- cord-335975-m6lkrehi 4030 14 90 90 CD cord-335975-m6lkrehi 4030 15 % % NN cord-335975-m6lkrehi 4030 16 ) ) -RRB- cord-335975-m6lkrehi 4030 17 . . . cord-335975-m6lkrehi 4031 1 Final final JJ cord-335975-m6lkrehi 4031 2 diagnosis diagnosis NN cord-335975-m6lkrehi 4031 3 in in IN cord-335975-m6lkrehi 4031 4 the the DT cord-335975-m6lkrehi 4031 5 ED ED NNP cord-335975-m6lkrehi 4031 6 was be VBD cord-335975-m6lkrehi 4031 7 considered consider VBN cord-335975-m6lkrehi 4031 8 as as IN cord-335975-m6lkrehi 4031 9 infectious infectious JJ cord-335975-m6lkrehi 4031 10 disease disease NN cord-335975-m6lkrehi 4031 11 ( ( -LRB- cord-335975-m6lkrehi 4031 12 ID ID NNP cord-335975-m6lkrehi 4031 13 ) ) -RRB- cord-335975-m6lkrehi 4031 14 in in IN cord-335975-m6lkrehi 4031 15 only only RB cord-335975-m6lkrehi 4031 16 142 142 CD cord-335975-m6lkrehi 4031 17 patients patient NNS cord-335975-m6lkrehi 4031 18 ( ( -LRB- cord-335975-m6lkrehi 4031 19 44.1 44.1 CD cord-335975-m6lkrehi 4031 20 % % NN cord-335975-m6lkrehi 4031 21 , , , cord-335975-m6lkrehi 4031 22 including include VBG cord-335975-m6lkrehi 4031 23 11 11 CD cord-335975-m6lkrehi 4031 24 sepsis sepsis NN cord-335975-m6lkrehi 4031 25 and and CC cord-335975-m6lkrehi 4031 26 5 5 CD cord-335975-m6lkrehi 4031 27 septic septic JJ cord-335975-m6lkrehi 4031 28 shocks shock NNS cord-335975-m6lkrehi 4031 29 ) ) -RRB- cord-335975-m6lkrehi 4031 30 . . . cord-335975-m6lkrehi 4032 1 175 175 CD cord-335975-m6lkrehi 4032 2 ( ( -LRB- cord-335975-m6lkrehi 4032 3 44.6 44.6 CD cord-335975-m6lkrehi 4032 4 % % NN cord-335975-m6lkrehi 4032 5 ) ) -RRB- cord-335975-m6lkrehi 4032 6 was be VBD cord-335975-m6lkrehi 4032 7 considered consider VBN cord-335975-m6lkrehi 4032 8 as as IN cord-335975-m6lkrehi 4032 9 non non JJ cord-335975-m6lkrehi 4032 10 - - JJ cord-335975-m6lkrehi 4032 11 infected infected JJ cord-335975-m6lkrehi 4032 12 ( ( -LRB- cord-335975-m6lkrehi 4032 13 NID NID NNP cord-335975-m6lkrehi 4032 14 ) ) -RRB- cord-335975-m6lkrehi 4032 15 and and CC cord-335975-m6lkrehi 4032 16 final final JJ cord-335975-m6lkrehi 4032 17 diagnosis diagnosis NN cord-335975-m6lkrehi 4032 18 remains remain VBZ cord-335975-m6lkrehi 4032 19 unprecise unprecise JJ cord-335975-m6lkrehi 4032 20 in in IN cord-335975-m6lkrehi 4032 21 8 8 CD cord-335975-m6lkrehi 4032 22 ( ( -LRB- cord-335975-m6lkrehi 4032 23 1.6 1.6 CD cord-335975-m6lkrehi 4032 24 % % NN cord-335975-m6lkrehi 4032 25 ) ) -RRB- cord-335975-m6lkrehi 4032 26 . . . cord-335975-m6lkrehi 4033 1 PCT pct NN cord-335975-m6lkrehi 4033 2 values value NNS cord-335975-m6lkrehi 4033 3 was be VBD cord-335975-m6lkrehi 4033 4 of of IN cord-335975-m6lkrehi 4033 5 0.42 0.42 CD cord-335975-m6lkrehi 4033 6 ( ( -LRB- cord-335975-m6lkrehi 4033 7 0 0 CD cord-335975-m6lkrehi 4033 8 - - SYM cord-335975-m6lkrehi 4033 9 1.38 1.38 CD cord-335975-m6lkrehi 4033 10 ) ) -RRB- cord-335975-m6lkrehi 4033 11 in in IN cord-335975-m6lkrehi 4033 12 the the DT cord-335975-m6lkrehi 4033 13 ID ID NNP cord-335975-m6lkrehi 4033 14 vs. vs. IN cord-335975-m6lkrehi 4033 15 0 0 NFP cord-335975-m6lkrehi 4033 16 ( ( -LRB- cord-335975-m6lkrehi 4033 17 0 0 CD cord-335975-m6lkrehi 4033 18 - - SYM cord-335975-m6lkrehi 4033 19 1.37 1.37 CD cord-335975-m6lkrehi 4033 20 ) ) -RRB- cord-335975-m6lkrehi 4033 21 in in IN cord-335975-m6lkrehi 4033 22 the the DT cord-335975-m6lkrehi 4033 23 NID NID NNP cord-335975-m6lkrehi 4033 24 ( ( -LRB- cord-335975-m6lkrehi 4033 25 p p NN cord-335975-m6lkrehi 4033 26 < < XX cord-335975-m6lkrehi 4033 27 0.001 0.001 CD cord-335975-m6lkrehi 4033 28 ) ) -RRB- cord-335975-m6lkrehi 4033 29 , , , cord-335975-m6lkrehi 4033 30 WBC WBC NNP cord-335975-m6lkrehi 4033 31 was be VBD cord-335975-m6lkrehi 4033 32 of of IN cord-335975-m6lkrehi 4033 33 10.68 10.68 CD cord-335975-m6lkrehi 4033 34 in in IN cord-335975-m6lkrehi 4033 35 the the DT cord-335975-m6lkrehi 4033 36 ID ID NNP cord-335975-m6lkrehi 4033 37 vs. vs. IN cord-335975-m6lkrehi 4033 38 9.75 9.75 CD cord-335975-m6lkrehi 4033 39 in in IN cord-335975-m6lkrehi 4033 40 the the DT cord-335975-m6lkrehi 4033 41 NID NID NNP cord-335975-m6lkrehi 4033 42 ( ( -LRB- cord-335975-m6lkrehi 4033 43 p p NN cord-335975-m6lkrehi 4033 44 < < XX cord-335975-m6lkrehi 4033 45 0.013 0.013 CD cord-335975-m6lkrehi 4033 46 ) ) -RRB- cord-335975-m6lkrehi 4033 47 and and CC cord-335975-m6lkrehi 4033 48 CRP CRP NNP cord-335975-m6lkrehi 4033 49 was be VBD cord-335975-m6lkrehi 4033 50 of of IN cord-335975-m6lkrehi 4033 51 88 88 CD cord-335975-m6lkrehi 4033 52 ( ( -LRB- cord-335975-m6lkrehi 4033 53 22.5 22.5 CD cord-335975-m6lkrehi 4033 54 - - HYPH cord-335975-m6lkrehi 4033 55 185.5 185.5 CD cord-335975-m6lkrehi 4033 56 ) ) -RRB- cord-335975-m6lkrehi 4033 57 in in IN cord-335975-m6lkrehi 4033 58 the the DT cord-335975-m6lkrehi 4033 59 ID ID NNP cord-335975-m6lkrehi 4033 60 vs. vs. IN cord-335975-m6lkrehi 4033 61 21 21 CD cord-335975-m6lkrehi 4033 62 ( ( -LRB- cord-335975-m6lkrehi 4033 63 5 5 CD cord-335975-m6lkrehi 4033 64 - - SYM cord-335975-m6lkrehi 4033 65 76 76 CD cord-335975-m6lkrehi 4033 66 ) ) -RRB- cord-335975-m6lkrehi 4033 67 in in IN cord-335975-m6lkrehi 4033 68 the the DT cord-335975-m6lkrehi 4033 69 NID NID NNP cord-335975-m6lkrehi 4033 70 ( ( -LRB- cord-335975-m6lkrehi 4033 71 p p NN cord-335975-m6lkrehi 4033 72 < < XX cord-335975-m6lkrehi 4033 73 0.001 0.001 CD cord-335975-m6lkrehi 4033 74 ) ) -RRB- cord-335975-m6lkrehi 4033 75 . . . cord-335975-m6lkrehi 4034 1 No no DT cord-335975-m6lkrehi 4034 2 correlation correlation NN cord-335975-m6lkrehi 4034 3 was be VBD cord-335975-m6lkrehi 4034 4 observed observe VBN cord-335975-m6lkrehi 4034 5 between between IN cord-335975-m6lkrehi 4034 6 the the DT cord-335975-m6lkrehi 4034 7 PCT PCT NNP cord-335975-m6lkrehi 4034 8 value value NN cord-335975-m6lkrehi 4034 9 and and CC cord-335975-m6lkrehi 4034 10 admission admission NN cord-335975-m6lkrehi 4034 11 to to IN cord-335975-m6lkrehi 4034 12 dechocage dechocage VB cord-335975-m6lkrehi 4034 13 room room NN cord-335975-m6lkrehi 4034 14 admission admission NN cord-335975-m6lkrehi 4034 15 . . . cord-335975-m6lkrehi 4034 16 . . . cord-335975-m6lkrehi 4035 1 Identification identification NN cord-335975-m6lkrehi 4035 2 of of IN cord-335975-m6lkrehi 4035 3 the the DT cord-335975-m6lkrehi 4035 4 involved involved JJ cord-335975-m6lkrehi 4035 5 drug drug NN cord-335975-m6lkrehi 4035 6 was be VBD cord-335975-m6lkrehi 4035 7 obtained obtain VBN cord-335975-m6lkrehi 4035 8 in in IN cord-335975-m6lkrehi 4035 9 60 60 CD cord-335975-m6lkrehi 4035 10 % % NN cord-335975-m6lkrehi 4035 11 of of IN cord-335975-m6lkrehi 4035 12 the the DT cord-335975-m6lkrehi 4035 13 cases case NNS cord-335975-m6lkrehi 4035 14 , , , cord-335975-m6lkrehi 4035 15 based base VBN cord-335975-m6lkrehi 4035 16 on on IN cord-335975-m6lkrehi 4035 17 qualitative qualitative JJ cord-335975-m6lkrehi 4035 18 screening screening NN cord-335975-m6lkrehi 4035 19 . . . cord-335975-m6lkrehi 4036 1 Management management NN cord-335975-m6lkrehi 4036 2 was be VBD cord-335975-m6lkrehi 4036 3 mainly mainly RB cord-335975-m6lkrehi 4036 4 supportive supportive JJ cord-335975-m6lkrehi 4036 5 and and CC cord-335975-m6lkrehi 4036 6 included include VBD cord-335975-m6lkrehi 4036 7 sedation sedation NN cord-335975-m6lkrehi 4036 8 ( ( -LRB- cord-335975-m6lkrehi 4036 9 13 13 CD cord-335975-m6lkrehi 4036 10 % % NN cord-335975-m6lkrehi 4036 11 ) ) -RRB- cord-335975-m6lkrehi 4036 12 , , , cord-335975-m6lkrehi 4036 13 naloxone naloxone NN cord-335975-m6lkrehi 4036 14 ( ( -LRB- cord-335975-m6lkrehi 4036 15 10 10 CD cord-335975-m6lkrehi 4036 16 % % NN cord-335975-m6lkrehi 4036 17 ) ) -RRB- cord-335975-m6lkrehi 4036 18 and and CC cord-335975-m6lkrehi 4036 19 flumazenil flumazenil NNP cord-335975-m6lkrehi 4036 20 ( ( -LRB- cord-335975-m6lkrehi 4036 21 1 1 CD cord-335975-m6lkrehi 4036 22 % % NN cord-335975-m6lkrehi 4036 23 ) ) -RRB- cord-335975-m6lkrehi 4036 24 . . . cord-335975-m6lkrehi 4037 1 Tracheal tracheal JJ cord-335975-m6lkrehi 4037 2 intubation intubation NN cord-335975-m6lkrehi 4037 3 was be VBD cord-335975-m6lkrehi 4037 4 required require VBN cord-335975-m6lkrehi 4037 5 in in IN cord-335975-m6lkrehi 4037 6 3 3 CD cord-335975-m6lkrehi 4037 7 patients patient NNS cord-335975-m6lkrehi 4037 8 ( ( -LRB- cord-335975-m6lkrehi 4037 9 0.4 0.4 CD cord-335975-m6lkrehi 4037 10 % % NN cord-335975-m6lkrehi 4037 11 ) ) -RRB- cord-335975-m6lkrehi 4037 12 . . . cord-335975-m6lkrehi 4038 1 One one CD cord-335975-m6lkrehi 4038 2 cardiac cardiac JJ cord-335975-m6lkrehi 4038 3 arrest arrest NN cord-335975-m6lkrehi 4038 4 but but CC cord-335975-m6lkrehi 4038 5 no no DT cord-335975-m6lkrehi 4038 6 death death NN cord-335975-m6lkrehi 4038 7 occurred occur VBD cord-335975-m6lkrehi 4038 8 in in IN cord-335975-m6lkrehi 4038 9 the the DT cord-335975-m6lkrehi 4038 10 ED ED NNP cord-335975-m6lkrehi 4038 11 . . . cord-335975-m6lkrehi 4039 1 Forty forty CD cord-335975-m6lkrehi 4039 2 - - HYPH cord-335975-m6lkrehi 4039 3 three three CD cord-335975-m6lkrehi 4039 4 patients patient NNS cord-335975-m6lkrehi 4039 5 ( ( -LRB- cord-335975-m6lkrehi 4039 6 6 6 CD cord-335975-m6lkrehi 4039 7 % % NN cord-335975-m6lkrehi 4039 8 ) ) -RRB- cord-335975-m6lkrehi 4039 9 were be VBD cord-335975-m6lkrehi 4039 10 transferred transfer VBN cord-335975-m6lkrehi 4039 11 to to IN cord-335975-m6lkrehi 4039 12 the the DT cord-335975-m6lkrehi 4039 13 intensive intensive JJ cord-335975-m6lkrehi 4039 14 care care NN cord-335975-m6lkrehi 4039 15 unit unit NN cord-335975-m6lkrehi 4039 16 . . . cord-335975-m6lkrehi 4040 1 Conclusion conclusion NN cord-335975-m6lkrehi 4040 2 : : : cord-335975-m6lkrehi 4041 1 Our -PRON- PRP$ cord-335975-m6lkrehi 4041 2 dataset dataset NN cord-335975-m6lkrehi 4041 3 provides provide VBZ cord-335975-m6lkrehi 4041 4 an an DT cord-335975-m6lkrehi 4041 5 interesting interesting JJ cord-335975-m6lkrehi 4041 6 insight insight NN cord-335975-m6lkrehi 4041 7 into into IN cord-335975-m6lkrehi 4041 8 the the DT cord-335975-m6lkrehi 4041 9 drugs drug NNS cord-335975-m6lkrehi 4041 10 involved involve VBN cord-335975-m6lkrehi 4041 11 in in IN cord-335975-m6lkrehi 4041 12 and and CC cord-335975-m6lkrehi 4041 13 clinical clinical JJ cord-335975-m6lkrehi 4041 14 pattern pattern NN cord-335975-m6lkrehi 4041 15 of of IN cord-335975-m6lkrehi 4041 16 toxicity toxicity NN cord-335975-m6lkrehi 4041 17 outcome outcome NN cord-335975-m6lkrehi 4041 18 of of IN cord-335975-m6lkrehi 4041 19 acute acute JJ cord-335975-m6lkrehi 4041 20 recreational recreational JJ cord-335975-m6lkrehi 4041 21 drug drug NN cord-335975-m6lkrehi 4041 22 toxicity toxicity NN cord-335975-m6lkrehi 4041 23 presentations presentation NNS cord-335975-m6lkrehi 4041 24 at at IN cord-335975-m6lkrehi 4041 25 the the DT cord-335975-m6lkrehi 4041 26 ED ED NNP cord-335975-m6lkrehi 4041 27 , , , cord-335975-m6lkrehi 4041 28 despite despite IN cord-335975-m6lkrehi 4041 29 possible possible JJ cord-335975-m6lkrehi 4041 30 under under NN cord-335975-m6lkrehi 4041 31 - - HYPH cord-335975-m6lkrehi 4041 32 declaration declaration NN cord-335975-m6lkrehi 4041 33 and and CC cord-335975-m6lkrehi 4041 34 coding coding NN cord-335975-m6lkrehi 4041 35 . . . cord-335975-m6lkrehi 4042 1 Classical classical JJ cord-335975-m6lkrehi 4042 2 recreational recreational JJ cord-335975-m6lkrehi 4042 3 drugs drug NNS cord-335975-m6lkrehi 4042 4 were be VBD cord-335975-m6lkrehi 4042 5 more more RBR cord-335975-m6lkrehi 4042 6 common common JJ cord-335975-m6lkrehi 4042 7 ( ( -LRB- cord-335975-m6lkrehi 4042 8 77 77 CD cord-335975-m6lkrehi 4042 9 % % NN cord-335975-m6lkrehi 4042 10 ) ) -RRB- cord-335975-m6lkrehi 4042 11 followed follow VBN cord-335975-m6lkrehi 4042 12 by by IN cord-335975-m6lkrehi 4042 13 prescription prescription NN cord-335975-m6lkrehi 4042 14 drugs drug NNS cord-335975-m6lkrehi 4042 15 ( ( -LRB- cord-335975-m6lkrehi 4042 16 20 20 CD cord-335975-m6lkrehi 4042 17 % % NN cord-335975-m6lkrehi 4042 18 ) ) -RRB- cord-335975-m6lkrehi 4042 19 and and CC cord-335975-m6lkrehi 4042 20 NPS NPS NNP cord-335975-m6lkrehi 4042 21 ( ( -LRB- cord-335975-m6lkrehi 4042 22 3 3 CD cord-335975-m6lkrehi 4042 23 % % NN cord-335975-m6lkrehi 4042 24 ) ) -RRB- cord-335975-m6lkrehi 4042 25 . . . cord-335975-m6lkrehi 4043 1 and and CC cord-335975-m6lkrehi 4043 2 drug drug NN cord-335975-m6lkrehi 4043 3 ( ( -LRB- cord-335975-m6lkrehi 4043 4 59 59 CD cord-335975-m6lkrehi 4043 5 % % NN cord-335975-m6lkrehi 4043 6 ) ) -RRB- cord-335975-m6lkrehi 4043 7 consumers consumer NNS cord-335975-m6lkrehi 4043 8 + + SYM cord-335975-m6lkrehi 4043 9 HIV HIV NNP cord-335975-m6lkrehi 4043 10 - - HYPH cord-335975-m6lkrehi 4043 11 infected infect VBN cord-335975-m6lkrehi 4043 12 ( ( -LRB- cord-335975-m6lkrehi 4043 13 58 58 CD cord-335975-m6lkrehi 4043 14 % % NN cord-335975-m6lkrehi 4043 15 ) ) -RRB- cord-335975-m6lkrehi 4043 16 and and CC cord-335975-m6lkrehi 4043 17 depressive depressive JJ cord-335975-m6lkrehi 4043 18 ( ( -LRB- cord-335975-m6lkrehi 4043 19 25 25 CD cord-335975-m6lkrehi 4043 20 % % NN cord-335975-m6lkrehi 4043 21 ) ) -RRB- cord-335975-m6lkrehi 4043 22 patients patient NNS cord-335975-m6lkrehi 4043 23 ) ) -RRB- cord-335975-m6lkrehi 4043 24 were be VBD cord-335975-m6lkrehi 4043 25 admitted admit VBN cord-335975-m6lkrehi 4043 26 to to IN cord-335975-m6lkrehi 4043 27 the the DT cord-335975-m6lkrehi 4043 28 ICU ICU NNP cord-335975-m6lkrehi 4043 29 . . . cord-335975-m6lkrehi 4044 1 The the DT cord-335975-m6lkrehi 4044 2 main main JJ cord-335975-m6lkrehi 4044 3 declared declare VBN cord-335975-m6lkrehi 4044 4 compounds compound NNS cord-335975-m6lkrehi 4044 5 were be VBD cord-335975-m6lkrehi 4044 6 methylenedioxypyrovalerone methylenedioxypyrovalerone JJ cord-335975-m6lkrehi 4044 7 ( ( -LRB- cord-335975-m6lkrehi 4044 8 MDPV MDPV NNP cord-335975-m6lkrehi 4044 9 + + -RRB- cord-335975-m6lkrehi 4045 1 N n NN cord-335975-m6lkrehi 4045 2 = = SYM cord-335975-m6lkrehi 4045 3 9 9 CD cord-335975-m6lkrehi 4045 4 ) ) -RRB- cord-335975-m6lkrehi 4045 5 , , , cord-335975-m6lkrehi 4045 6 4-methylethcathinone 4-methylethcathinone CD cord-335975-m6lkrehi 4045 7 ( ( -LRB- cord-335975-m6lkrehi 4045 8 4-MEC 4-mec CD cord-335975-m6lkrehi 4045 9 + + SYM cord-335975-m6lkrehi 4045 10 N n NN cord-335975-m6lkrehi 4045 11 = = SYM cord-335975-m6lkrehi 4045 12 6 6 CD cord-335975-m6lkrehi 4045 13 ) ) -RRB- cord-335975-m6lkrehi 4045 14 , , , cord-335975-m6lkrehi 4045 15 3-methyl 3-methyl CD cord-335975-m6lkrehi 4045 16 methcathinone methcathinone NN cord-335975-m6lkrehi 4045 17 ( ( -LRB- cord-335975-m6lkrehi 4045 18 3-MMC 3-mmc CD cord-335975-m6lkrehi 4045 19 + + SYM cord-335975-m6lkrehi 4045 20 N n NN cord-335975-m6lkrehi 4045 21 = = SYM cord-335975-m6lkrehi 4045 22 3 3 CD cord-335975-m6lkrehi 4045 23 ) ) -RRB- cord-335975-m6lkrehi 4045 24 and and CC cord-335975-m6lkrehi 4045 25 4-methyl 4-methyl CD cord-335975-m6lkrehi 4045 26 methcathinone methcathinone NN cord-335975-m6lkrehi 4046 1 ( ( -LRB- cord-335975-m6lkrehi 4046 2 4-MMC 4-mmc CD cord-335975-m6lkrehi 4046 3 + + SYM cord-335975-m6lkrehi 4046 4 N n NN cord-335975-m6lkrehi 4046 5 = = SYM cord-335975-m6lkrehi 4046 6 3 3 CD cord-335975-m6lkrehi 4046 7 ) ) -RRB- cord-335975-m6lkrehi 4046 8 , , , cord-335975-m6lkrehi 4046 9 more more RBR cord-335975-m6lkrehi 4046 10 frequently frequently RB cord-335975-m6lkrehi 4046 11 used use VBN cord-335975-m6lkrehi 4046 12 in in IN cord-335975-m6lkrehi 4046 13 drug drug NN cord-335975-m6lkrehi 4046 14 mixtures mixture NNS cord-335975-m6lkrehi 4046 15 sold sell VBN cord-335975-m6lkrehi 4046 16 as as IN cord-335975-m6lkrehi 4046 17 bath bath NN cord-335975-m6lkrehi 4046 18 salts salt NNS cord-335975-m6lkrehi 4046 19 or or CC cord-335975-m6lkrehi 4046 20 in in IN cord-335975-m6lkrehi 4046 21 poly poly JJ cord-335975-m6lkrehi 4046 22 - - HYPH cord-335975-m6lkrehi 4046 23 intoxication intoxication NN cord-335975-m6lkrehi 4046 24 with with IN cord-335975-m6lkrehi 4046 25 conventional conventional JJ cord-335975-m6lkrehi 4046 26 illegal illegal JJ cord-335975-m6lkrehi 4046 27 drugs drug NNS cord-335975-m6lkrehi 4046 28 ( ( -LRB- cord-335975-m6lkrehi 4046 29 mainly mainly RB cord-335975-m6lkrehi 4046 30 cocaine cocaine NN cord-335975-m6lkrehi 4046 31 and and CC cord-335975-m6lkrehi 4046 32 gamma gamma NN cord-335975-m6lkrehi 4046 33 - - HYPH cord-335975-m6lkrehi 4046 34 hydroxybutyrate hydroxybutyrate NN cord-335975-m6lkrehi 4046 35 ) ) -RRB- cord-335975-m6lkrehi 4046 36 . . . cord-335975-m6lkrehi 4047 1 NPS NPS NNP cord-335975-m6lkrehi 4047 2 was be VBD cord-335975-m6lkrehi 4047 3 used use VBN cord-335975-m6lkrehi 4047 4 in in IN cord-335975-m6lkrehi 4047 5 a a DT cord-335975-m6lkrehi 4047 6 recreational recreational NN cord-335975-m6lkrehi 4047 7 ( ( -LRB- cord-335975-m6lkrehi 4047 8 71 71 CD cord-335975-m6lkrehi 4047 9 % % NN cord-335975-m6lkrehi 4047 10 ) ) -RRB- cord-335975-m6lkrehi 4047 11 , , , cord-335975-m6lkrehi 4047 12 Chemsex Chemsex NNP cord-335975-m6lkrehi 4047 13 ( ( -LRB- cord-335975-m6lkrehi 4047 14 29 29 CD cord-335975-m6lkrehi 4047 15 % % NN cord-335975-m6lkrehi 4047 16 ) ) -RRB- cord-335975-m6lkrehi 4047 17 or or CC cord-335975-m6lkrehi 4047 18 solitary solitary JJ cord-335975-m6lkrehi 4047 19 practice practice NN cord-335975-m6lkrehi 4047 20 ( ( -LRB- cord-335975-m6lkrehi 4047 21 29 29 CD cord-335975-m6lkrehi 4047 22 % % NN cord-335975-m6lkrehi 4047 23 ) ) -RRB- cord-335975-m6lkrehi 4047 24 . . . cord-335975-m6lkrehi 4048 1 Binge binge NN cord-335975-m6lkrehi 4048 2 ( ( -LRB- cord-335975-m6lkrehi 4048 3 63 63 CD cord-335975-m6lkrehi 4048 4 % % NN cord-335975-m6lkrehi 4048 5 ) ) -RRB- cord-335975-m6lkrehi 4048 6 and and CC cord-335975-m6lkrehi 4048 7 intravenous intravenous JJ cord-335975-m6lkrehi 4048 8 ( ( -LRB- cord-335975-m6lkrehi 4048 9 50 50 CD cord-335975-m6lkrehi 4048 10 % % NN cord-335975-m6lkrehi 4048 11 ) ) -RRB- cord-335975-m6lkrehi 4048 12 self self NN cord-335975-m6lkrehi 4048 13 - - HYPH cord-335975-m6lkrehi 4048 14 administration administration NN cord-335975-m6lkrehi 4048 15 was be VBD cord-335975-m6lkrehi 4048 16 remarkable remarkable JJ cord-335975-m6lkrehi 4048 17 . . . cord-335975-m6lkrehi 4049 1 Patients patient NNS cord-335975-m6lkrehi 4049 2 presented present VBD cord-335975-m6lkrehi 4049 3 acute acute JJ cord-335975-m6lkrehi 4049 4 encephalopathy encephalopathy NN cord-335975-m6lkrehi 4049 5 with with IN cord-335975-m6lkrehi 4049 6 psychomotor psychomotor JJ cord-335975-m6lkrehi 4049 7 agitation agitation NN cord-335975-m6lkrehi 4049 8 ( ( -LRB- cord-335975-m6lkrehi 4049 9 46 46 CD cord-335975-m6lkrehi 4049 10 % % NN cord-335975-m6lkrehi 4049 11 ) ) -RRB- cord-335975-m6lkrehi 4049 12 , , , cord-335975-m6lkrehi 4049 13 confusion confusion NN cord-335975-m6lkrehi 4049 14 ( ( -LRB- cord-335975-m6lkrehi 4049 15 38 38 CD cord-335975-m6lkrehi 4049 16 % % NN cord-335975-m6lkrehi 4049 17 + + CC cord-335975-m6lkrehi 4049 18 Glasgow Glasgow NNP cord-335975-m6lkrehi 4049 19 coma coma NN cord-335975-m6lkrehi 4050 1 score-14 score-14 NNP cord-335975-m6lkrehi 4050 2 [ [ -LRB- cord-335975-m6lkrehi 4050 3 9 9 CD cord-335975-m6lkrehi 4050 4 ] ] -RRB- cord-335975-m6lkrehi 4050 5 ) ) -RRB- cord-335975-m6lkrehi 4050 6 , , , cord-335975-m6lkrehi 4050 7 hallucinations hallucination NNS cord-335975-m6lkrehi 4050 8 ( ( -LRB- cord-335975-m6lkrehi 4050 9 33 33 CD cord-335975-m6lkrehi 4050 10 % % NN cord-335975-m6lkrehi 4050 11 ) ) -RRB- cord-335975-m6lkrehi 4050 12 , , , cord-335975-m6lkrehi 4050 13 anxiety anxiety NN cord-335975-m6lkrehi 4050 14 ( ( -LRB- cord-335975-m6lkrehi 4050 15 17 17 CD cord-335975-m6lkrehi 4050 16 % % NN cord-335975-m6lkrehi 4050 17 ) ) -RRB- cord-335975-m6lkrehi 4050 18 , , , cord-335975-m6lkrehi 4050 19 seizures seizure NNS cord-335975-m6lkrehi 4050 20 ( ( -LRB- cord-335975-m6lkrehi 4050 21 17 17 CD cord-335975-m6lkrehi 4050 22 % % NN cord-335975-m6lkrehi 4050 23 ) ) -RRB- cord-335975-m6lkrehi 4050 24 , , , cord-335975-m6lkrehi 4050 25 myoclonus myoclonus FW cord-335975-m6lkrehi 4050 26 ( ( -LRB- cord-335975-m6lkrehi 4050 27 13 13 CD cord-335975-m6lkrehi 4050 28 % % NN cord-335975-m6lkrehi 4050 29 ) ) -RRB- cord-335975-m6lkrehi 4050 30 and and CC cord-335975-m6lkrehi 4050 31 stereotypes stereotype NNS cord-335975-m6lkrehi 4050 32 ( ( -LRB- cord-335975-m6lkrehi 4050 33 13 13 CD cord-335975-m6lkrehi 4050 34 % % NN cord-335975-m6lkrehi 4050 35 ) ) -RRB- cord-335975-m6lkrehi 4050 36 . . . cord-335975-m6lkrehi 4051 1 ECG ECG NNP cord-335975-m6lkrehi 4051 2 typically typically RB cord-335975-m6lkrehi 4051 3 showed show VBD cord-335975-m6lkrehi 4051 4 sinus sinus NN cord-335975-m6lkrehi 4051 5 tachycardia tachycardia NN cord-335975-m6lkrehi 4051 6 ( ( -LRB- cord-335975-m6lkrehi 4051 7 70 70 CD cord-335975-m6lkrehi 4051 8 % % NN cord-335975-m6lkrehi 4051 9 ) ) -RRB- cord-335975-m6lkrehi 4051 10 , , , cord-335975-m6lkrehi 4051 11 QRS QRS NNP cord-335975-m6lkrehi 4051 12 QT QT NNP cord-335975-m6lkrehi 4051 13 abnormalities abnormality NNS cord-335975-m6lkrehi 4051 14 ( ( -LRB- cord-335975-m6lkrehi 4051 15 13 13 CD cord-335975-m6lkrehi 4051 16 % % NN cord-335975-m6lkrehi 4051 17 ) ) -RRB- cord-335975-m6lkrehi 4051 18 and and CC cord-335975-m6lkrehi 4051 19 atrio atrio JJ cord-335975-m6lkrehi 4051 20 - - HYPH cord-335975-m6lkrehi 4051 21 ventricular ventricular JJ cord-335975-m6lkrehi 4051 22 block block NN cord-335975-m6lkrehi 4051 23 ( ( -LRB- cord-335975-m6lkrehi 4051 24 4 4 CD cord-335975-m6lkrehi 4051 25 % % NN cord-335975-m6lkrehi 4051 26 ) ) -RRB- cord-335975-m6lkrehi 4051 27 . . . cord-335975-m6lkrehi 4052 1 Acute acute JJ cord-335975-m6lkrehi 4052 2 cardiac cardiac JJ cord-335975-m6lkrehi 4052 3 ischemia ischemia NN cord-335975-m6lkrehi 4052 4 ( ( -LRB- cord-335975-m6lkrehi 4052 5 17 17 CD cord-335975-m6lkrehi 4052 6 % % NN cord-335975-m6lkrehi 4052 7 ) ) -RRB- cord-335975-m6lkrehi 4052 8 and and CC cord-335975-m6lkrehi 4052 9 dysfunction dysfunction NN cord-335975-m6lkrehi 4052 10 ( ( -LRB- cord-335975-m6lkrehi 4052 11 13 13 CD cord-335975-m6lkrehi 4052 12 % % NN cord-335975-m6lkrehi 4052 13 ) ) -RRB- cord-335975-m6lkrehi 4052 14 , , , cord-335975-m6lkrehi 4052 15 disseminated disseminate VBN cord-335975-m6lkrehi 4052 16 intravascular intravascular JJ cord-335975-m6lkrehi 4052 17 coagulation coagulation NN cord-335975-m6lkrehi 4052 18 ( ( -LRB- cord-335975-m6lkrehi 4052 19 8 8 CD cord-335975-m6lkrehi 4052 20 % % NN cord-335975-m6lkrehi 4052 21 ) ) -RRB- cord-335975-m6lkrehi 4052 22 and and CC cord-335975-m6lkrehi 4052 23 multiorgan multiorgan NN cord-335975-m6lkrehi 4052 24 failure failure NN cord-335975-m6lkrehi 4052 25 ( ( -LRB- cord-335975-m6lkrehi 4052 26 Results result NNS cord-335975-m6lkrehi 4052 27 : : : cord-335975-m6lkrehi 4052 28 During during IN cord-335975-m6lkrehi 4052 29 the the DT cord-335975-m6lkrehi 4052 30 first first JJ cord-335975-m6lkrehi 4052 31 and and CC cord-335975-m6lkrehi 4052 32 the the DT cord-335975-m6lkrehi 4052 33 second second JJ cord-335975-m6lkrehi 4052 34 study study NN cord-335975-m6lkrehi 4052 35 periods period VBZ cord-335975-m6lkrehi 4052 36 204 204 CD cord-335975-m6lkrehi 4052 37 and and CC cord-335975-m6lkrehi 4052 38 244 244 CD cord-335975-m6lkrehi 4052 39 patients patient NNS cord-335975-m6lkrehi 4052 40 were be VBD cord-335975-m6lkrehi 4052 41 respectively respectively RB cord-335975-m6lkrehi 4052 42 admitted admit VBN cord-335975-m6lkrehi 4052 43 in in IN cord-335975-m6lkrehi 4052 44 the the DT cord-335975-m6lkrehi 4052 45 ICU ICU NNP cord-335975-m6lkrehi 4052 46 . . . cord-335975-m6lkrehi 4053 1 Total total JJ cord-335975-m6lkrehi 4053 2 micro micro JJ cord-335975-m6lkrehi 4053 3 - - HYPH cord-335975-m6lkrehi 4053 4 organisms organism NNS cord-335975-m6lkrehi 4053 5 density density NN cord-335975-m6lkrehi 4053 6 was be VBD cord-335975-m6lkrehi 4053 7 48 48 CD cord-335975-m6lkrehi 4053 8 and and CC cord-335975-m6lkrehi 4053 9 69.5 69.5 CD cord-335975-m6lkrehi 4053 10 for for IN cord-335975-m6lkrehi 4053 11 100 100 CD cord-335975-m6lkrehi 4053 12 patients patient NNS cord-335975-m6lkrehi 4053 13 for for IN cord-335975-m6lkrehi 4053 14 the the DT cord-335975-m6lkrehi 4053 15 first first JJ cord-335975-m6lkrehi 4053 16 and and CC cord-335975-m6lkrehi 4053 17 the the DT cord-335975-m6lkrehi 4053 18 second second JJ cord-335975-m6lkrehi 4053 19 period period NN cord-335975-m6lkrehi 4053 20 , , , cord-335975-m6lkrehi 4053 21 respectively respectively RB cord-335975-m6lkrehi 4053 22 ( ( -LRB- cord-335975-m6lkrehi 4053 23 p p NN cord-335975-m6lkrehi 4053 24 < < XX cord-335975-m6lkrehi 4053 25 0.05 0.05 CD cord-335975-m6lkrehi 4053 26 ) ) -RRB- cord-335975-m6lkrehi 4053 27 . . . cord-335975-m6lkrehi 4054 1 Acinetobacter Acinetobacter NNP cord-335975-m6lkrehi 4054 2 spp spp NNS cord-335975-m6lkrehi 4054 3 and and CC cord-335975-m6lkrehi 4054 4 Pseudomonas Pseudomonas NNP cord-335975-m6lkrehi 4054 5 Aeroginosa Aeroginosa NNP cord-335975-m6lkrehi 4054 6 were be VBD cord-335975-m6lkrehi 4054 7 the the DT cord-335975-m6lkrehi 4054 8 predominant predominant JJ cord-335975-m6lkrehi 4054 9 isolated isolate VBN cord-335975-m6lkrehi 4054 10 microorganisms microorganism NNS cord-335975-m6lkrehi 4054 11 with with IN cord-335975-m6lkrehi 4054 12 a a DT cord-335975-m6lkrehi 4054 13 respective respective JJ cord-335975-m6lkrehi 4054 14 density density NN cord-335975-m6lkrehi 4054 15 of of IN cord-335975-m6lkrehi 4054 16 13.2 13.2 CD cord-335975-m6lkrehi 4054 17 and and CC cord-335975-m6lkrehi 4054 18 11.2 11.2 CD cord-335975-m6lkrehi 4054 19 isolates isolate NNS cord-335975-m6lkrehi 4054 20 for for IN cord-335975-m6lkrehi 4054 21 100 100 CD cord-335975-m6lkrehi 4054 22 patients patient NNS cord-335975-m6lkrehi 4054 23 . . . cord-335975-m6lkrehi 4055 1 Figure figure NN cord-335975-m6lkrehi 4055 2 1 1 CD cord-335975-m6lkrehi 4055 3 summarizes summarize VBZ cord-335975-m6lkrehi 4055 4 the the DT cord-335975-m6lkrehi 4055 5 patterns pattern NNS cord-335975-m6lkrehi 4055 6 of of IN cord-335975-m6lkrehi 4055 7 bacterial bacterial JJ cord-335975-m6lkrehi 4055 8 ecology ecology NN cord-335975-m6lkrehi 4055 9 and and CC cord-335975-m6lkrehi 4055 10 resistance resistance NN cord-335975-m6lkrehi 4055 11 in in IN cord-335975-m6lkrehi 4055 12 our -PRON- PRP$ cord-335975-m6lkrehi 4055 13 ICU ICU NNP cord-335975-m6lkrehi 4055 14 before before RB cord-335975-m6lkrehi 4055 15 and and CC cord-335975-m6lkrehi 4055 16 after after IN cord-335975-m6lkrehi 4055 17 transfer transfer NN cord-335975-m6lkrehi 4055 18 to to IN cord-335975-m6lkrehi 4055 19 new new JJ cord-335975-m6lkrehi 4055 20 buildings building NNS cord-335975-m6lkrehi 4055 21 , , , cord-335975-m6lkrehi 4055 22 showing show VBG cord-335975-m6lkrehi 4055 23 a a DT cord-335975-m6lkrehi 4055 24 significant significant JJ cord-335975-m6lkrehi 4055 25 decrease decrease NN cord-335975-m6lkrehi 4055 26 in in IN cord-335975-m6lkrehi 4055 27 Pseudomonas Pseudomonas NNP cord-335975-m6lkrehi 4055 28 aeroginosa aeroginosa NN cord-335975-m6lkrehi 4055 29 resistance resistance NN cord-335975-m6lkrehi 4055 30 for for IN cord-335975-m6lkrehi 4055 31 ticarcillin ticarcillin NNP cord-335975-m6lkrehi 4055 32 and and CC cord-335975-m6lkrehi 4055 33 ceftazidim ceftazidim NNP cord-335975-m6lkrehi 4055 34 , , , cord-335975-m6lkrehi 4055 35 whereas whereas IN cord-335975-m6lkrehi 4055 36 Acinetobacter Acinetobacter NNP cord-335975-m6lkrehi 4055 37 resistant resistant JJ cord-335975-m6lkrehi 4055 38 to to IN cord-335975-m6lkrehi 4055 39 carbapenems carbapenem NNS cord-335975-m6lkrehi 4055 40 and and CC cord-335975-m6lkrehi 4055 41 Enterobacteriacae Enterobacteriacae NNP cord-335975-m6lkrehi 4055 42 ESBL ESBL NNP cord-335975-m6lkrehi 4056 1 significantly significantly RB cord-335975-m6lkrehi 4056 2 increased increase VBN cord-335975-m6lkrehi 4056 3 . . . cord-335975-m6lkrehi 4057 1 Our -PRON- PRP$ cord-335975-m6lkrehi 4057 2 study study NN cord-335975-m6lkrehi 4057 3 suggests suggest VBZ cord-335975-m6lkrehi 4057 4 that that IN cord-335975-m6lkrehi 4057 5 transfer transfer NN cord-335975-m6lkrehi 4057 6 of of IN cord-335975-m6lkrehi 4057 7 ICU ICU NNP cord-335975-m6lkrehi 4057 8 to to IN cord-335975-m6lkrehi 4057 9 the the DT cord-335975-m6lkrehi 4057 10 new new JJ cord-335975-m6lkrehi 4057 11 buildings building NNS cord-335975-m6lkrehi 4057 12 was be VBD cord-335975-m6lkrehi 4057 13 associated associate VBN cord-335975-m6lkrehi 4057 14 with with IN cord-335975-m6lkrehi 4057 15 a a DT cord-335975-m6lkrehi 4057 16 decrease decrease NN cord-335975-m6lkrehi 4057 17 of of IN cord-335975-m6lkrehi 4057 18 Pseudomonas Pseudomonas NNP cord-335975-m6lkrehi 4057 19 aeroginosa aeroginosa NN cord-335975-m6lkrehi 4057 20 resistance resistance NN cord-335975-m6lkrehi 4057 21 , , , cord-335975-m6lkrehi 4057 22 whereas whereas IN cord-335975-m6lkrehi 4057 23 Acinetobacter Acinetobacter NNP cord-335975-m6lkrehi 4057 24 spp spp VBZ cord-335975-m6lkrehi 4057 25 resistance resistance NN cord-335975-m6lkrehi 4057 26 and and CC cord-335975-m6lkrehi 4057 27 ESBL ESBL NNP cord-335975-m6lkrehi 4057 28 Enterobacteriacae Enterobacteriacae NNP cord-335975-m6lkrehi 4057 29 incidence incidence NN cord-335975-m6lkrehi 4057 30 increased increase VBD cord-335975-m6lkrehi 4057 31 . . . cord-335975-m6lkrehi 4058 1 Introduction introduction NN cord-335975-m6lkrehi 4058 2 : : : cord-335975-m6lkrehi 4059 1 Infections infection NNS cord-335975-m6lkrehi 4059 2 caused cause VBN cord-335975-m6lkrehi 4059 3 by by IN cord-335975-m6lkrehi 4059 4 antimicrobial antimicrobial JJ cord-335975-m6lkrehi 4059 5 - - HYPH cord-335975-m6lkrehi 4059 6 resistant resistant JJ cord-335975-m6lkrehi 4059 7 bacteria bacteria NNS cord-335975-m6lkrehi 4059 8 ( ( -LRB- cord-335975-m6lkrehi 4059 9 AMRB AMRB NNP cord-335975-m6lkrehi 4059 10 ) ) -RRB- cord-335975-m6lkrehi 4059 11 are be VBP cord-335975-m6lkrehi 4059 12 one one CD cord-335975-m6lkrehi 4059 13 of of IN cord-335975-m6lkrehi 4059 14 the the DT cord-335975-m6lkrehi 4059 15 main main JJ cord-335975-m6lkrehi 4059 16 issues issue NNS cord-335975-m6lkrehi 4059 17 in in IN cord-335975-m6lkrehi 4059 18 the the DT cord-335975-m6lkrehi 4059 19 spectrum spectrum NN cord-335975-m6lkrehi 4059 20 of of IN cord-335975-m6lkrehi 4059 21 critically critically RB cord-335975-m6lkrehi 4059 22 ill ill JJ cord-335975-m6lkrehi 4059 23 patients patient NNS cord-335975-m6lkrehi 4059 24 as as IN cord-335975-m6lkrehi 4059 25 they -PRON- PRP cord-335975-m6lkrehi 4059 26 are be VBP cord-335975-m6lkrehi 4059 27 associated associate VBN cord-335975-m6lkrehi 4059 28 with with IN cord-335975-m6lkrehi 4059 29 higher high JJR cord-335975-m6lkrehi 4059 30 mortality mortality NN cord-335975-m6lkrehi 4059 31 , , , cord-335975-m6lkrehi 4059 32 morbidity morbidity NN cord-335975-m6lkrehi 4059 33 , , , cord-335975-m6lkrehi 4059 34 and and CC cord-335975-m6lkrehi 4059 35 length length NN cord-335975-m6lkrehi 4059 36 of of IN cord-335975-m6lkrehi 4059 37 stay stay NN cord-335975-m6lkrehi 4059 38 . . . cord-335975-m6lkrehi 4060 1 Thus thus RB cord-335975-m6lkrehi 4060 2 , , , cord-335975-m6lkrehi 4060 3 an an DT cord-335975-m6lkrehi 4060 4 appropriate appropriate JJ cord-335975-m6lkrehi 4060 5 initial initial JJ cord-335975-m6lkrehi 4060 6 antimicrobial antimicrobial JJ cord-335975-m6lkrehi 4060 7 therapy therapy NN cord-335975-m6lkrehi 4060 8 is be VBZ cord-335975-m6lkrehi 4060 9 decisive decisive JJ cord-335975-m6lkrehi 4060 10 for for IN cord-335975-m6lkrehi 4060 11 better well JJR cord-335975-m6lkrehi 4060 12 patient patient JJ cord-335975-m6lkrehi 4060 13 outcomes outcome NNS cord-335975-m6lkrehi 4060 14 . . . cord-335975-m6lkrehi 4061 1 The the DT cord-335975-m6lkrehi 4061 2 aim aim NN cord-335975-m6lkrehi 4061 3 of of IN cord-335975-m6lkrehi 4061 4 the the DT cord-335975-m6lkrehi 4061 5 study study NN cord-335975-m6lkrehi 4061 6 is be VBZ cord-335975-m6lkrehi 4061 7 to to TO cord-335975-m6lkrehi 4061 8 determine determine VB cord-335975-m6lkrehi 4061 9 the the DT cord-335975-m6lkrehi 4061 10 adequacy adequacy NN cord-335975-m6lkrehi 4061 11 of of IN cord-335975-m6lkrehi 4061 12 first first JJ cord-335975-m6lkrehi 4061 13 - - HYPH cord-335975-m6lkrehi 4061 14 line line NN cord-335975-m6lkrehi 4061 15 antibiotic antibiotic JJ cord-335975-m6lkrehi 4061 16 therapy therapy NN cord-335975-m6lkrehi 4061 17 guided guide VBN cord-335975-m6lkrehi 4061 18 by by IN cord-335975-m6lkrehi 4061 19 weekly weekly JJ cord-335975-m6lkrehi 4061 20 AMRB AMRB NNP cord-335975-m6lkrehi 4061 21 screenings screening NNS cord-335975-m6lkrehi 4061 22 . . . cord-335975-m6lkrehi 4062 1 Patients patient NNS cord-335975-m6lkrehi 4062 2 and and CC cord-335975-m6lkrehi 4062 3 methods method NNS cord-335975-m6lkrehi 4062 4 : : : cord-335975-m6lkrehi 4062 5 A a DT cord-335975-m6lkrehi 4062 6 9 9 CD cord-335975-m6lkrehi 4062 7 months month NNS cord-335975-m6lkrehi 4062 8 prospective prospective JJ cord-335975-m6lkrehi 4062 9 study study NN cord-335975-m6lkrehi 4062 10 was be VBD cord-335975-m6lkrehi 4062 11 conducted conduct VBN cord-335975-m6lkrehi 4062 12 in in IN cord-335975-m6lkrehi 4062 13 6-bed 6-bed NNP cord-335975-m6lkrehi 4062 14 MICU MICU NNP cord-335975-m6lkrehi 4062 15 . . . cord-335975-m6lkrehi 4063 1 Were be VBD cord-335975-m6lkrehi 4063 2 included include VBN cord-335975-m6lkrehi 4063 3 all all DT cord-335975-m6lkrehi 4063 4 patients patient NNS cord-335975-m6lkrehi 4063 5 with with IN cord-335975-m6lkrehi 4063 6 more more JJR cord-335975-m6lkrehi 4063 7 than than IN cord-335975-m6lkrehi 4063 8 48H 48h CD cord-335975-m6lkrehi 4063 9 of of IN cord-335975-m6lkrehi 4063 10 ICU ICU NNP cord-335975-m6lkrehi 4063 11 stay stay VBP cord-335975-m6lkrehi 4063 12 . . . cord-335975-m6lkrehi 4064 1 An an DT cord-335975-m6lkrehi 4064 2 AMRB AMRB NNP cord-335975-m6lkrehi 4064 3 screening screening NN cord-335975-m6lkrehi 4064 4 was be VBD cord-335975-m6lkrehi 4064 5 conducted conduct VBN cord-335975-m6lkrehi 4064 6 upon upon IN cord-335975-m6lkrehi 4064 7 admission admission NN cord-335975-m6lkrehi 4064 8 and and CC cord-335975-m6lkrehi 4064 9 on on IN cord-335975-m6lkrehi 4064 10 weekly weekly JJ cord-335975-m6lkrehi 4064 11 basis basis NN cord-335975-m6lkrehi 4064 12 for for IN cord-335975-m6lkrehi 4064 13 all all PDT cord-335975-m6lkrehi 4064 14 the the DT cord-335975-m6lkrehi 4064 15 patients patient NNS cord-335975-m6lkrehi 4064 16 . . . cord-335975-m6lkrehi 4065 1 The the DT cord-335975-m6lkrehi 4065 2 choice choice NN cord-335975-m6lkrehi 4065 3 of of IN cord-335975-m6lkrehi 4065 4 antibiotherapy antibiotherapy NNP cord-335975-m6lkrehi 4065 5 if if IN cord-335975-m6lkrehi 4065 6 indicated indicate VBN cord-335975-m6lkrehi 4065 7 , , , cord-335975-m6lkrehi 4065 8 was be VBD cord-335975-m6lkrehi 4065 9 guided guide VBN cord-335975-m6lkrehi 4065 10 by by IN cord-335975-m6lkrehi 4065 11 the the DT cord-335975-m6lkrehi 4065 12 most most RBS cord-335975-m6lkrehi 4065 13 recent recent JJ cord-335975-m6lkrehi 4065 14 colonization colonization NN cord-335975-m6lkrehi 4065 15 results result NNS cord-335975-m6lkrehi 4065 16 . . . cord-335975-m6lkrehi 4066 1 If if IN cord-335975-m6lkrehi 4066 2 the the DT cord-335975-m6lkrehi 4066 3 patient patient NN cord-335975-m6lkrehi 4066 4 has have VBZ cord-335975-m6lkrehi 4066 5 received receive VBN cord-335975-m6lkrehi 4066 6 at at IN cord-335975-m6lkrehi 4066 7 least least RBS cord-335975-m6lkrehi 4066 8 one one CD cord-335975-m6lkrehi 4066 9 active active JJ cord-335975-m6lkrehi 4066 10 in in IN cord-335975-m6lkrehi 4066 11 vitro vitro FW cord-335975-m6lkrehi 4066 12 antibiotic antibiotic JJ cord-335975-m6lkrehi 4066 13 against against IN cord-335975-m6lkrehi 4066 14 the the DT cord-335975-m6lkrehi 4066 15 isolated isolate VBN cord-335975-m6lkrehi 4066 16 bacteria bacteria NNS cord-335975-m6lkrehi 4066 17 , , , cord-335975-m6lkrehi 4066 18 the the DT cord-335975-m6lkrehi 4066 19 empiric empiric JJ cord-335975-m6lkrehi 4066 20 antibiotherapy antibiotherapy NN cord-335975-m6lkrehi 4066 21 was be VBD cord-335975-m6lkrehi 4066 22 considered consider VBN cord-335975-m6lkrehi 4066 23 appropriate appropriate JJ cord-335975-m6lkrehi 4066 24 . . . cord-335975-m6lkrehi 4067 1 Results result NNS cord-335975-m6lkrehi 4067 2 : : : cord-335975-m6lkrehi 4068 1 98 98 CD cord-335975-m6lkrehi 4068 2 patients patient NNS cord-335975-m6lkrehi 4068 3 were be VBD cord-335975-m6lkrehi 4068 4 included include VBN cord-335975-m6lkrehi 4068 5 in in IN cord-335975-m6lkrehi 4068 6 the the DT cord-335975-m6lkrehi 4068 7 study study NN cord-335975-m6lkrehi 4068 8 . . . cord-335975-m6lkrehi 4069 1 Mean mean JJ cord-335975-m6lkrehi 4069 2 age age NN cord-335975-m6lkrehi 4069 3 and and CC cord-335975-m6lkrehi 4069 4 SAPS SAPS NNP cord-335975-m6lkrehi 4069 5 II II NNP cord-335975-m6lkrehi 4069 6 were be VBD cord-335975-m6lkrehi 4069 7 respectively respectively RB cord-335975-m6lkrehi 4069 8 56 56 CD cord-335975-m6lkrehi 4069 9 ± ± CD cord-335975-m6lkrehi 4069 10 20 20 CD cord-335975-m6lkrehi 4069 11 years year NNS cord-335975-m6lkrehi 4069 12 and and CC cord-335975-m6lkrehi 4069 13 41 41 CD cord-335975-m6lkrehi 4069 14 ± ± CD cord-335975-m6lkrehi 4069 15 20 20 CD cord-335975-m6lkrehi 4069 16 . . . cord-335975-m6lkrehi 4070 1 The the DT cord-335975-m6lkrehi 4070 2 median median JJ cord-335975-m6lkrehi 4070 3 length length NN cord-335975-m6lkrehi 4070 4 of of IN cord-335975-m6lkrehi 4070 5 stay stay NN cord-335975-m6lkrehi 4070 6 was be VBD cord-335975-m6lkrehi 4070 7 8 8 CD cord-335975-m6lkrehi 4070 8 days day NNS cord-335975-m6lkrehi 4070 9 . . . cord-335975-m6lkrehi 4071 1 11 11 CD cord-335975-m6lkrehi 4071 2 ( ( -LRB- cord-335975-m6lkrehi 4071 3 11 11 CD cord-335975-m6lkrehi 4071 4 % % NN cord-335975-m6lkrehi 4071 5 ) ) -RRB- cord-335975-m6lkrehi 4071 6 patients patient NNS cord-335975-m6lkrehi 4071 7 were be VBD cord-335975-m6lkrehi 4071 8 colonized colonize VBN cord-335975-m6lkrehi 4071 9 by by IN cord-335975-m6lkrehi 4071 10 AMRB AMRB NNP cord-335975-m6lkrehi 4071 11 upon upon IN cord-335975-m6lkrehi 4071 12 admission admission NN cord-335975-m6lkrehi 4071 13 . . . cord-335975-m6lkrehi 4072 1 The the DT cord-335975-m6lkrehi 4072 2 most most RBS cord-335975-m6lkrehi 4072 3 frequent frequent JJ cord-335975-m6lkrehi 4072 4 isolated isolate VBN cord-335975-m6lkrehi 4072 5 microorganisms microorganism NNS cord-335975-m6lkrehi 4072 6 were be VBD cord-335975-m6lkrehi 4072 7 - - : cord-335975-m6lkrehi 4072 8 Escherichia escherichia NN cord-335975-m6lkrehi 4072 9 coli coli NNS cord-335975-m6lkrehi 4072 10 5 5 CD cord-335975-m6lkrehi 4072 11 ( ( -LRB- cord-335975-m6lkrehi 4072 12 55 55 CD cord-335975-m6lkrehi 4072 13 % % NN cord-335975-m6lkrehi 4072 14 ) ) -RRB- cord-335975-m6lkrehi 4072 15 and and CC cord-335975-m6lkrehi 4072 16 Klebsiella Klebsiella NNP cord-335975-m6lkrehi 4072 17 pneumonia pneumonia NN cord-335975-m6lkrehi 4072 18 4 4 CD cord-335975-m6lkrehi 4072 19 ( ( -LRB- cord-335975-m6lkrehi 4072 20 45 45 CD cord-335975-m6lkrehi 4072 21 % % NN cord-335975-m6lkrehi 4072 22 ) ) -RRB- cord-335975-m6lkrehi 4072 23 . . . cord-335975-m6lkrehi 4073 1 Were be VBD cord-335975-m6lkrehi 4073 2 assessed assess VBN cord-335975-m6lkrehi 4073 3 57 57 CD cord-335975-m6lkrehi 4073 4 hospital hospital NN cord-335975-m6lkrehi 4073 5 - - HYPH cord-335975-m6lkrehi 4073 6 acquired acquire VBN cord-335975-m6lkrehi 4073 7 infections infection NNS cord-335975-m6lkrehi 4073 8 ( ( -LRB- cord-335975-m6lkrehi 4073 9 HAI)-32 HAI)-32 NNP cord-335975-m6lkrehi 4073 10 ( ( -LRB- cord-335975-m6lkrehi 4073 11 56 56 CD cord-335975-m6lkrehi 4073 12 % % NN cord-335975-m6lkrehi 4073 13 ) ) -RRB- cord-335975-m6lkrehi 4073 14 in in IN cord-335975-m6lkrehi 4073 15 AMRB AMRB NNP cord-335975-m6lkrehi 4073 16 colonized colonize VBD cord-335975-m6lkrehi 4073 17 patients patient NNS cord-335975-m6lkrehi 4073 18 and and CC cord-335975-m6lkrehi 4073 19 25 25 CD cord-335975-m6lkrehi 4073 20 ( ( -LRB- cord-335975-m6lkrehi 4073 21 44 44 CD cord-335975-m6lkrehi 4073 22 % % NN cord-335975-m6lkrehi 4073 23 ) ) -RRB- cord-335975-m6lkrehi 4073 24 in in IN cord-335975-m6lkrehi 4073 25 uncolonized uncolonized JJ cord-335975-m6lkrehi 4073 26 ones one NNS cord-335975-m6lkrehi 4073 27 . . . cord-335975-m6lkrehi 4074 1 The the DT cord-335975-m6lkrehi 4074 2 antibiotherapy antibiotherapy NN cord-335975-m6lkrehi 4074 3 was be VBD cord-335975-m6lkrehi 4074 4 considered consider VBN cord-335975-m6lkrehi 4074 5 appropriate appropriate JJ cord-335975-m6lkrehi 4074 6 in in IN cord-335975-m6lkrehi 4074 7 21 21 CD cord-335975-m6lkrehi 4074 8 infections infection NNS cord-335975-m6lkrehi 4074 9 ( ( -LRB- cord-335975-m6lkrehi 4074 10 65 65 CD cord-335975-m6lkrehi 4074 11 % % NN cord-335975-m6lkrehi 4074 12 ) ) -RRB- cord-335975-m6lkrehi 4074 13 . . . cord-335975-m6lkrehi 4075 1 Out out IN cord-335975-m6lkrehi 4075 2 of of IN cord-335975-m6lkrehi 4075 3 the the DT cord-335975-m6lkrehi 4075 4 20 20 CD cord-335975-m6lkrehi 4075 5 colonized colonize VBN cord-335975-m6lkrehi 4075 6 patients patient NNS cord-335975-m6lkrehi 4075 7 , , , cord-335975-m6lkrehi 4075 8 15 15 CD cord-335975-m6lkrehi 4075 9 ( ( -LRB- cord-335975-m6lkrehi 4075 10 75 75 CD cord-335975-m6lkrehi 4075 11 % % NN cord-335975-m6lkrehi 4075 12 ) ) -RRB- cord-335975-m6lkrehi 4075 13 developed develop VBD cord-335975-m6lkrehi 4075 14 HAI HAI NNP cord-335975-m6lkrehi 4075 15 . . . cord-335975-m6lkrehi 4076 1 11 11 CD cord-335975-m6lkrehi 4076 2 ( ( -LRB- cord-335975-m6lkrehi 4076 3 73 73 CD cord-335975-m6lkrehi 4076 4 % % NN cord-335975-m6lkrehi 4076 5 ) ) -RRB- cord-335975-m6lkrehi 4076 6 patients patient NNS cord-335975-m6lkrehi 4076 7 had have VBD cord-335975-m6lkrehi 4076 8 a a DT cord-335975-m6lkrehi 4076 9 concordant concordant JJ cord-335975-m6lkrehi 4076 10 colonization colonization NN cord-335975-m6lkrehi 4076 11 body body NN cord-335975-m6lkrehi 4076 12 site site NN cord-335975-m6lkrehi 4076 13 to to IN cord-335975-m6lkrehi 4076 14 the the DT cord-335975-m6lkrehi 4076 15 infection infection NN cord-335975-m6lkrehi 4076 16 . . . cord-335975-m6lkrehi 4077 1 Of of IN cord-335975-m6lkrehi 4077 2 the the DT cord-335975-m6lkrehi 4077 3 57 57 CD cord-335975-m6lkrehi 4077 4 nosocomial nosocomial JJ cord-335975-m6lkrehi 4077 5 infections infection NNS cord-335975-m6lkrehi 4077 6 , , , cord-335975-m6lkrehi 4077 7 ventilator ventilator NN cord-335975-m6lkrehi 4077 8 - - HYPH cord-335975-m6lkrehi 4077 9 associated associate VBN cord-335975-m6lkrehi 4077 10 pneumonias pneumonia NNS cord-335975-m6lkrehi 4077 11 and and CC cord-335975-m6lkrehi 4077 12 central central JJ cord-335975-m6lkrehi 4077 13 venous venous JJ cord-335975-m6lkrehi 4077 14 catheter catheter NN cord-335975-m6lkrehi 4077 15 infections infection NNS cord-335975-m6lkrehi 4077 16 were be VBD cord-335975-m6lkrehi 4077 17 the the DT cord-335975-m6lkrehi 4077 18 most most RBS cord-335975-m6lkrehi 4077 19 frequent frequent JJ cord-335975-m6lkrehi 4077 20 , , , cord-335975-m6lkrehi 4077 21 both both CC cord-335975-m6lkrehi 4077 22 at at IN cord-335975-m6lkrehi 4077 23 38 38 CD cord-335975-m6lkrehi 4077 24 % % NN cord-335975-m6lkrehi 4077 25 ( ( -LRB- cord-335975-m6lkrehi 4077 26 n n NN cord-335975-m6lkrehi 4077 27 = = SYM cord-335975-m6lkrehi 4077 28 22 22 CD cord-335975-m6lkrehi 4077 29 and and CC cord-335975-m6lkrehi 4077 30 n n NN cord-335975-m6lkrehi 4077 31 = = SYM cord-335975-m6lkrehi 4077 32 22 22 CD cord-335975-m6lkrehi 4077 33 ) ) -RRB- cord-335975-m6lkrehi 4077 34 + + CC cord-335975-m6lkrehi 4077 35 followed follow VBN cord-335975-m6lkrehi 4077 36 by by IN cord-335975-m6lkrehi 4077 37 urinary urinary JJ cord-335975-m6lkrehi 4077 38 tract tract JJ cord-335975-m6lkrehi 4077 39 infections infection NNS cord-335975-m6lkrehi 4077 40 21 21 CD cord-335975-m6lkrehi 4077 41 % % NN cord-335975-m6lkrehi 4077 42 ( ( -LRB- cord-335975-m6lkrehi 4077 43 n n NN cord-335975-m6lkrehi 4077 44 = = SYM cord-335975-m6lkrehi 4077 45 10 10 CD cord-335975-m6lkrehi 4077 46 ) ) -RRB- cord-335975-m6lkrehi 4077 47 and and CC cord-335975-m6lkrehi 4077 48 infective infective JJ cord-335975-m6lkrehi 4077 49 endocarditis endocarditis NN cord-335975-m6lkrehi 4077 50 2 2 CD cord-335975-m6lkrehi 4077 51 % % NN cord-335975-m6lkrehi 4077 52 ( ( -LRB- cord-335975-m6lkrehi 4077 53 n n NN cord-335975-m6lkrehi 4077 54 = = SYM cord-335975-m6lkrehi 4077 55 1 1 CD cord-335975-m6lkrehi 4077 56 ) ) -RRB- cord-335975-m6lkrehi 4077 57 . . . cord-335975-m6lkrehi 4078 1 ( ( -LRB- cord-335975-m6lkrehi 4078 2 42 42 CD cord-335975-m6lkrehi 4078 3 ) ) -RRB- cord-335975-m6lkrehi 4078 4 . . . cord-335975-m6lkrehi 4079 1 Overall overall RB cord-335975-m6lkrehi 4079 2 , , , cord-335975-m6lkrehi 4079 3 the the DT cord-335975-m6lkrehi 4079 4 isolates isolate NNS cord-335975-m6lkrehi 4079 5 were be VBD cord-335975-m6lkrehi 4079 6 - - HYPH cord-335975-m6lkrehi 4079 7 extended extend VBN cord-335975-m6lkrehi 4079 8 spectrum spectrum NN cord-335975-m6lkrehi 4079 9 betalactamase betalactamase NN cord-335975-m6lkrehi 4079 10 productrice productrice NNP cord-335975-m6lkrehi 4079 11 - - HYPH cord-335975-m6lkrehi 4079 12 Enterobacteria Enterobacteria NNP cord-335975-m6lkrehi 4079 13 ( ( -LRB- cord-335975-m6lkrehi 4079 14 43 43 CD cord-335975-m6lkrehi 4079 15 % % NN cord-335975-m6lkrehi 4079 16 ) ) -RRB- cord-335975-m6lkrehi 4079 17 , , , cord-335975-m6lkrehi 4079 18 imipenem imipenem NNP cord-335975-m6lkrehi 4079 19 resistant resistant JJ cord-335975-m6lkrehi 4079 20 - - HYPH cord-335975-m6lkrehi 4079 21 Acinetobacter Acinetobacter NNP cord-335975-m6lkrehi 4079 22 baumanii baumanii NN cord-335975-m6lkrehi 4079 23 ( ( -LRB- cord-335975-m6lkrehi 4079 24 30 30 CD cord-335975-m6lkrehi 4079 25 % % NN cord-335975-m6lkrehi 4079 26 ) ) -RRB- cord-335975-m6lkrehi 4079 27 , , , cord-335975-m6lkrehi 4079 28 and and CC cord-335975-m6lkrehi 4079 29 multi multi JJ cord-335975-m6lkrehi 4079 30 resistant resistant JJ cord-335975-m6lkrehi 4079 31 - - HYPH cord-335975-m6lkrehi 4079 32 Pseudomonas Pseudomonas NNP cord-335975-m6lkrehi 4079 33 aeroguinosa aeroguinosa NN cord-335975-m6lkrehi 4079 34 ( ( -LRB- cord-335975-m6lkrehi 4079 35 19 19 CD cord-335975-m6lkrehi 4079 36 % % NN cord-335975-m6lkrehi 4079 37 ) ) -RRB- cord-335975-m6lkrehi 4079 38 . . . cord-335975-m6lkrehi 4080 1 50 50 CD cord-335975-m6lkrehi 4080 2 NI NI NNP cord-335975-m6lkrehi 4080 3 were be VBD cord-335975-m6lkrehi 4080 4 documented document VBN cord-335975-m6lkrehi 4080 5 including include VBG cord-335975-m6lkrehi 4080 6 35 35 CD cord-335975-m6lkrehi 4080 7 caused cause VBN cord-335975-m6lkrehi 4080 8 by by IN cord-335975-m6lkrehi 4080 9 MDR MDR NNP cord-335975-m6lkrehi 4080 10 bacteria bacteria NNS cord-335975-m6lkrehi 4080 11 and and CC cord-335975-m6lkrehi 4080 12 distributed distribute VBN cord-335975-m6lkrehi 4080 13 as as IN cord-335975-m6lkrehi 4080 14 follows follow VBZ cord-335975-m6lkrehi 4080 15 - - HYPH cord-335975-m6lkrehi 4080 16 ventilator ventilator NN cord-335975-m6lkrehi 4080 17 acquired acquire VBN cord-335975-m6lkrehi 4080 18 pneumonia pneumonia NN cord-335975-m6lkrehi 4080 19 - - HYPH cord-335975-m6lkrehi 4080 20 VAP VAP NNP cord-335975-m6lkrehi 4080 21 ( ( -LRB- cord-335975-m6lkrehi 4080 22 n n NN cord-335975-m6lkrehi 4080 23 = = SYM cord-335975-m6lkrehi 4080 24 19 19 CD cord-335975-m6lkrehi 4080 25 ) ) -RRB- cord-335975-m6lkrehi 4080 26 , , , cord-335975-m6lkrehi 4080 27 bacteraemia bacteraemia NNP cord-335975-m6lkrehi 4080 28 ( ( -LRB- cord-335975-m6lkrehi 4080 29 n n NN cord-335975-m6lkrehi 4080 30 = = SYM cord-335975-m6lkrehi 4080 31 6 6 CD cord-335975-m6lkrehi 4080 32 ) ) -RRB- cord-335975-m6lkrehi 4080 33 , , , cord-335975-m6lkrehi 4080 34 VAP VAP NNP cord-335975-m6lkrehi 4080 35 with with IN cord-335975-m6lkrehi 4080 36 bacteraemia bacteraemia NNP cord-335975-m6lkrehi 4080 37 ( ( -LRB- cord-335975-m6lkrehi 4080 38 n n NN cord-335975-m6lkrehi 4080 39 = = SYM cord-335975-m6lkrehi 4080 40 4 4 CD cord-335975-m6lkrehi 4080 41 ) ) -RRB- cord-335975-m6lkrehi 4080 42 , , . cord-335975-m6lkrehi 4081 1 catheter catheter NN cord-335975-m6lkrehi 4081 2 related related JJ cord-335975-m6lkrehi 4081 3 infection infection NN cord-335975-m6lkrehi 4081 4 - - : cord-335975-m6lkrehi 4081 5 CRI CRI NNP cord-335975-m6lkrehi 4081 6 ( ( -LRB- cord-335975-m6lkrehi 4081 7 n n NN cord-335975-m6lkrehi 4081 8 = = SYM cord-335975-m6lkrehi 4081 9 3 3 CD cord-335975-m6lkrehi 4081 10 ) ) -RRB- cord-335975-m6lkrehi 4081 11 , , , cord-335975-m6lkrehi 4081 12 CRI CRI NNP cord-335975-m6lkrehi 4081 13 with with IN cord-335975-m6lkrehi 4081 14 VAP VAP NNP cord-335975-m6lkrehi 4081 15 ( ( -LRB- cord-335975-m6lkrehi 4081 16 n n NN cord-335975-m6lkrehi 4081 17 = = SYM cord-335975-m6lkrehi 4081 18 2 2 CD cord-335975-m6lkrehi 4081 19 ) ) -RRB- cord-335975-m6lkrehi 4081 20 and and CC cord-335975-m6lkrehi 4081 21 catheter catheter NN cord-335975-m6lkrehi 4081 22 - - HYPH cord-335975-m6lkrehi 4081 23 related relate VBN cord-335975-m6lkrehi 4081 24 bacteraemia bacteraemia NN cord-335975-m6lkrehi 4081 25 - - HYPH cord-335975-m6lkrehi 4081 26 CRB CRB NNP cord-335975-m6lkrehi 4081 27 ( ( -LRB- cord-335975-m6lkrehi 4081 28 n n NN cord-335975-m6lkrehi 4081 29 = = SYM cord-335975-m6lkrehi 4081 30 1 1 CD cord-335975-m6lkrehi 4081 31 ) ) -RRB- cord-335975-m6lkrehi 4081 32 . . . cord-335975-m6lkrehi 4082 1 The the DT cord-335975-m6lkrehi 4082 2 performance performance NN cord-335975-m6lkrehi 4082 3 of of IN cord-335975-m6lkrehi 4082 4 MDR MDR NNP cord-335975-m6lkrehi 4082 5 bacteria bacteria NNS cord-335975-m6lkrehi 4082 6 - - : cord-335975-m6lkrehi 4082 7 screening screening NN cord-335975-m6lkrehi 4082 8 in in IN cord-335975-m6lkrehi 4082 9 predicting predict VBG cord-335975-m6lkrehi 4082 10 NI NI NNP cord-335975-m6lkrehi 4082 11 was be VBD cord-335975-m6lkrehi 4082 12 poor poor JJ cord-335975-m6lkrehi 4082 13 with with IN cord-335975-m6lkrehi 4082 14 71 71 CD cord-335975-m6lkrehi 4082 15 % % NN cord-335975-m6lkrehi 4082 16 of of IN cord-335975-m6lkrehi 4082 17 sensitivity sensitivity NN cord-335975-m6lkrehi 4082 18 , , , cord-335975-m6lkrehi 4082 19 58 58 CD cord-335975-m6lkrehi 4082 20 % % NN cord-335975-m6lkrehi 4082 21 of of IN cord-335975-m6lkrehi 4082 22 specificity specificity NN cord-335975-m6lkrehi 4082 23 , , , cord-335975-m6lkrehi 4082 24 41.5 41.5 CD cord-335975-m6lkrehi 4082 25 % % NN cord-335975-m6lkrehi 4082 26 of of IN cord-335975-m6lkrehi 4082 27 negative negative JJ cord-335975-m6lkrehi 4082 28 predictive predictive JJ cord-335975-m6lkrehi 4082 29 value value NN cord-335975-m6lkrehi 4082 30 ( ( -LRB- cord-335975-m6lkrehi 4082 31 NPV NPV NNP cord-335975-m6lkrehi 4082 32 ) ) -RRB- cord-335975-m6lkrehi 4082 33 , , , cord-335975-m6lkrehi 4082 34 and and CC cord-335975-m6lkrehi 4082 35 83 83 CD cord-335975-m6lkrehi 4082 36 % % NN cord-335975-m6lkrehi 4082 37 of of IN cord-335975-m6lkrehi 4082 38 positive positive JJ cord-335975-m6lkrehi 4082 39 predictive predictive JJ cord-335975-m6lkrehi 4082 40 value value NN cord-335975-m6lkrehi 4082 41 ( ( -LRB- cord-335975-m6lkrehi 4082 42 PPV PPV NNP cord-335975-m6lkrehi 4082 43 ) ) -RRB- cord-335975-m6lkrehi 4082 44 . . . cord-335975-m6lkrehi 4083 1 Nevertheless nevertheless RB cord-335975-m6lkrehi 4083 2 , , , cord-335975-m6lkrehi 4083 3 the the DT cord-335975-m6lkrehi 4083 4 performance performance NN cord-335975-m6lkrehi 4083 5 of of IN cord-335975-m6lkrehi 4083 6 the the DT cord-335975-m6lkrehi 4083 7 nasal nasal NN cord-335975-m6lkrehi 4083 8 swab swab NN cord-335975-m6lkrehi 4083 9 in in IN cord-335975-m6lkrehi 4083 10 the the DT cord-335975-m6lkrehi 4083 11 prediction prediction NN cord-335975-m6lkrehi 4083 12 of of IN cord-335975-m6lkrehi 4083 13 VAP VAP NNP cord-335975-m6lkrehi 4083 14 was be VBD cord-335975-m6lkrehi 4083 15 better well JJR cord-335975-m6lkrehi 4083 16 with with IN cord-335975-m6lkrehi 4083 17 85 85 CD cord-335975-m6lkrehi 4083 18 % % NN cord-335975-m6lkrehi 4083 19 of of IN cord-335975-m6lkrehi 4083 20 sensitivity sensitivity NN cord-335975-m6lkrehi 4083 21 and and CC cord-335975-m6lkrehi 4083 22 92.3 92.3 CD cord-335975-m6lkrehi 4083 23 % % NN cord-335975-m6lkrehi 4083 24 of of IN cord-335975-m6lkrehi 4083 25 NPV NPV NNP cord-335975-m6lkrehi 4083 26 . . . cord-335975-m6lkrehi 4084 1 Conclusion conclusion NN cord-335975-m6lkrehi 4084 2 : : : cord-335975-m6lkrehi 4084 3 MDR MDR NNP cord-335975-m6lkrehi 4084 4 bacteria bacteria NNS cord-335975-m6lkrehi 4084 5 - - HYPH cord-335975-m6lkrehi 4084 6 screening screening NN cord-335975-m6lkrehi 4084 7 is be VBZ cord-335975-m6lkrehi 4084 8 useful useful JJ cord-335975-m6lkrehi 4084 9 as as IN cord-335975-m6lkrehi 4084 10 it -PRON- PRP cord-335975-m6lkrehi 4084 11 allows allow VBZ cord-335975-m6lkrehi 4084 12 to to IN cord-335975-m6lkrehi 4084 13 identifying identify VBG cord-335975-m6lkrehi 4084 14 the the DT cord-335975-m6lkrehi 4084 15 MDR MDR NNP cord-335975-m6lkrehi 4084 16 bacteria bacteria NNS cord-335975-m6lkrehi 4084 17 - - HYPH cord-335975-m6lkrehi 4084 18 carriers carrier NNS cord-335975-m6lkrehi 4084 19 and and CC cord-335975-m6lkrehi 4084 20 helps help VBZ cord-335975-m6lkrehi 4084 21 for for IN cord-335975-m6lkrehi 4084 22 a a DT cord-335975-m6lkrehi 4084 23 rational rational JJ cord-335975-m6lkrehi 4084 24 use use NN cord-335975-m6lkrehi 4084 25 of of IN cord-335975-m6lkrehi 4084 26 antibiotics antibiotic NNS cord-335975-m6lkrehi 4084 27 in in IN cord-335975-m6lkrehi 4084 28 severe severe JJ cord-335975-m6lkrehi 4084 29 NI NI NNP cord-335975-m6lkrehi 4084 30 . . . cord-335975-m6lkrehi 4085 1 However however RB cord-335975-m6lkrehi 4085 2 , , , cord-335975-m6lkrehi 4085 3 its -PRON- PRP$ cord-335975-m6lkrehi 4085 4 diagnostic diagnostic JJ cord-335975-m6lkrehi 4085 5 contribution contribution NN cord-335975-m6lkrehi 4085 6 in in IN cord-335975-m6lkrehi 4085 7 the the DT cord-335975-m6lkrehi 4085 8 occurrence occurrence NN cord-335975-m6lkrehi 4085 9 of of IN cord-335975-m6lkrehi 4085 10 NI NI NNP cord-335975-m6lkrehi 4085 11 is be VBZ cord-335975-m6lkrehi 4085 12 poor poor JJ cord-335975-m6lkrehi 4085 13 except except IN cord-335975-m6lkrehi 4085 14 the the DT cord-335975-m6lkrehi 4085 15 interest interest NN cord-335975-m6lkrehi 4085 16 of of IN cord-335975-m6lkrehi 4085 17 the the DT cord-335975-m6lkrehi 4085 18 nasal nasal NN cord-335975-m6lkrehi 4085 19 swab swab NN cord-335975-m6lkrehi 4085 20 in in IN cord-335975-m6lkrehi 4085 21 the the DT cord-335975-m6lkrehi 4085 22 prediction prediction NN cord-335975-m6lkrehi 4085 23 of of IN cord-335975-m6lkrehi 4085 24 VAP VAP NNP cord-335975-m6lkrehi 4085 25 owing owe VBG cord-335975-m6lkrehi 4085 26 to to IN cord-335975-m6lkrehi 4085 27 its -PRON- PRP$ cord-335975-m6lkrehi 4085 28 good good JJ cord-335975-m6lkrehi 4085 29 NPV NPV NNP cord-335975-m6lkrehi 4085 30 . . . cord-335975-m6lkrehi 4086 1 We -PRON- PRP cord-335975-m6lkrehi 4086 2 aimed aim VBD cord-335975-m6lkrehi 4086 3 at at IN cord-335975-m6lkrehi 4086 4 determining determine VBG cord-335975-m6lkrehi 4086 5 the the DT cord-335975-m6lkrehi 4086 6 respective respective JJ cord-335975-m6lkrehi 4086 7 weight weight NN cord-335975-m6lkrehi 4086 8 of of IN cord-335975-m6lkrehi 4086 9 these these DT cord-335975-m6lkrehi 4086 10 phenomenon phenomenon NN cord-335975-m6lkrehi 4086 11 and and CC cord-335975-m6lkrehi 4086 12 the the DT cord-335975-m6lkrehi 4086 13 physiological physiological JJ cord-335975-m6lkrehi 4086 14 determinants determinant NNS cord-335975-m6lkrehi 4086 15 of of IN cord-335975-m6lkrehi 4086 16 the the DT cord-335975-m6lkrehi 4086 17 respiratory respiratory JJ cord-335975-m6lkrehi 4086 18 variations variation NNS cord-335975-m6lkrehi 4086 19 of of IN cord-335975-m6lkrehi 4086 20 the the DT cord-335975-m6lkrehi 4086 21 IVC IVC NNP cord-335975-m6lkrehi 4086 22 diameter diameter NN cord-335975-m6lkrehi 4086 23 . . . cord-335975-m6lkrehi 4087 1 Patients patient NNS cord-335975-m6lkrehi 4087 2 and and CC cord-335975-m6lkrehi 4087 3 methods method NNS cord-335975-m6lkrehi 4087 4 : : : cord-335975-m6lkrehi 4087 5 In in IN cord-335975-m6lkrehi 4087 6 21 21 CD cord-335975-m6lkrehi 4087 7 mechanically mechanically RB cord-335975-m6lkrehi 4087 8 ventilated ventilate VBN cord-335975-m6lkrehi 4087 9 patients patient NNS cord-335975-m6lkrehi 4087 10 ( ( -LRB- cord-335975-m6lkrehi 4087 11 tidal tidal JJ cord-335975-m6lkrehi 4087 12 volume-6.2 volume-6.2 NN cord-335975-m6lkrehi 4087 13 ± ± CD cord-335975-m6lkrehi 4087 14 1.0 1.0 CD cord-335975-m6lkrehi 4087 15 mL ml NN cord-335975-m6lkrehi 4087 16 kg kg NNS cord-335975-m6lkrehi 4087 17 of of IN cord-335975-m6lkrehi 4087 18 predicted predict VBN cord-335975-m6lkrehi 4087 19 body body NN cord-335975-m6lkrehi 4087 20 weight weight NN cord-335975-m6lkrehi 4087 21 ) ) -RRB- cord-335975-m6lkrehi 4087 22 haemodynamic haemodynamic NNP cord-335975-m6lkrehi 4087 23 , , , cord-335975-m6lkrehi 4087 24 respiratory respiratory JJ cord-335975-m6lkrehi 4087 25 and and CC cord-335975-m6lkrehi 4087 26 the the DT cord-335975-m6lkrehi 4087 27 intra intra JJ cord-335975-m6lkrehi 4087 28 - - JJ cord-335975-m6lkrehi 4087 29 abdominal abdominal JJ cord-335975-m6lkrehi 4087 30 pressure pressure NN cord-335975-m6lkrehi 4087 31 ( ( -LRB- cord-335975-m6lkrehi 4087 32 IAP IAP NNP cord-335975-m6lkrehi 4087 33 ) ) -RRB- cord-335975-m6lkrehi 4087 34 signals signal NNS cord-335975-m6lkrehi 4087 35 were be VBD cord-335975-m6lkrehi 4087 36 continuously continuously RB cord-335975-m6lkrehi 4087 37 computerised computerise VBN cord-335975-m6lkrehi 4087 38 . . . cord-335975-m6lkrehi 4088 1 CVP CVP NNP cord-335975-m6lkrehi 4088 2 , , , cord-335975-m6lkrehi 4088 3 IAP IAP NNP cord-335975-m6lkrehi 4088 4 and and CC cord-335975-m6lkrehi 4088 5 the the DT cord-335975-m6lkrehi 4088 6 IVC IVC NNP cord-335975-m6lkrehi 4088 7 diameter diameter NN cord-335975-m6lkrehi 4088 8 ( ( -LRB- cord-335975-m6lkrehi 4088 9 transthoracic transthoracic NNP cord-335975-m6lkrehi 4088 10 echocardiography echocardiography NN cord-335975-m6lkrehi 4088 11 ) ) -RRB- cord-335975-m6lkrehi 4088 12 were be VBD cord-335975-m6lkrehi 4088 13 recorded record VBN cord-335975-m6lkrehi 4088 14 during during IN cord-335975-m6lkrehi 4088 15 15-second 15-second JJ cord-335975-m6lkrehi 4088 16 end end NN cord-335975-m6lkrehi 4088 17 - - HYPH cord-335975-m6lkrehi 4088 18 inspiratory inspiratory JJ cord-335975-m6lkrehi 4088 19 and and CC cord-335975-m6lkrehi 4088 20 end end NN cord-335975-m6lkrehi 4088 21 - - HYPH cord-335975-m6lkrehi 4088 22 expiratory expiratory NN cord-335975-m6lkrehi 4088 23 occlusions occlusion NNS cord-335975-m6lkrehi 4088 24 separated separate VBN cord-335975-m6lkrehi 4088 25 by by IN cord-335975-m6lkrehi 4088 26 10 10 CD cord-335975-m6lkrehi 4088 27 s s NNPS cord-335975-m6lkrehi 4088 28 , , , cord-335975-m6lkrehi 4088 29 before before IN cord-335975-m6lkrehi 4088 30 and and CC cord-335975-m6lkrehi 4088 31 after after IN cord-335975-m6lkrehi 4088 32 the the DT cord-335975-m6lkrehi 4088 33 infusion infusion NN cord-335975-m6lkrehi 4088 34 of of IN cord-335975-m6lkrehi 4088 35 500-mL 500-ml CD cord-335975-m6lkrehi 4088 36 of of IN cord-335975-m6lkrehi 4088 37 saline saline NN cord-335975-m6lkrehi 4088 38 . . . cord-335975-m6lkrehi 4089 1 Patients patient NNS cord-335975-m6lkrehi 4089 2 in in IN cord-335975-m6lkrehi 4089 3 whom whom WP cord-335975-m6lkrehi 4089 4 fluid fluid NNP cord-335975-m6lkrehi 4089 5 administration administration NN cord-335975-m6lkrehi 4089 6 induced induce VBD cord-335975-m6lkrehi 4089 7 an an DT cord-335975-m6lkrehi 4089 8 increase increase NN cord-335975-m6lkrehi 4089 9 in in IN cord-335975-m6lkrehi 4089 10 cardiac cardiac JJ cord-335975-m6lkrehi 4089 11 index index NN cord-335975-m6lkrehi 4089 12 ( ( -LRB- cord-335975-m6lkrehi 4089 13 PICCO-2 picco-2 NN cord-335975-m6lkrehi 4089 14 ) ) -RRB- cord-335975-m6lkrehi 4089 15 > > XX cord-335975-m6lkrehi 4089 16 15 15 CD cord-335975-m6lkrehi 4089 17 % % NN cord-335975-m6lkrehi 4089 18 were be VBD cord-335975-m6lkrehi 4089 19 defined define VBN cord-335975-m6lkrehi 4089 20 as as IN cord-335975-m6lkrehi 4089 21 " " `` cord-335975-m6lkrehi 4089 22 responders responder NNS cord-335975-m6lkrehi 4089 23 " " '' cord-335975-m6lkrehi 4089 24 . . . cord-335975-m6lkrehi 4090 1 The the DT cord-335975-m6lkrehi 4090 2 respiratory respiratory JJ cord-335975-m6lkrehi 4090 3 variations variation NNS cord-335975-m6lkrehi 4090 4 of of IN cord-335975-m6lkrehi 4090 5 the the DT cord-335975-m6lkrehi 4090 6 IVC IVC NNP cord-335975-m6lkrehi 4090 7 diameter diameter NN cord-335975-m6lkrehi 4090 8 , , , cord-335975-m6lkrehi 4090 9 CVP CVP NNP cord-335975-m6lkrehi 4090 10 and and CC cord-335975-m6lkrehi 4090 11 IAP IAP NNP cord-335975-m6lkrehi 4090 12 were be VBD cord-335975-m6lkrehi 4090 13 calculated calculate VBN cord-335975-m6lkrehi 4090 14 as as IN cord-335975-m6lkrehi 4090 15 the the DT cord-335975-m6lkrehi 4090 16 ( ( -LRB- cord-335975-m6lkrehi 4090 17 end end NN cord-335975-m6lkrehi 4090 18 - - HYPH cord-335975-m6lkrehi 4090 19 inspiratory inspiratory JJ cord-335975-m6lkrehi 4090 20 - - HYPH cord-335975-m6lkrehi 4090 21 end end NN cord-335975-m6lkrehi 4090 22 - - HYPH cord-335975-m6lkrehi 4090 23 expiratory expiratory NN cord-335975-m6lkrehi 4090 24 values value NNS cord-335975-m6lkrehi 4090 25 ) ) -RRB- cord-335975-m6lkrehi 4090 26 mean mean JJ cord-335975-m6lkrehi 4090 27 value value NN cord-335975-m6lkrehi 4090 28 . . . cord-335975-m6lkrehi 4091 1 The the DT cord-335975-m6lkrehi 4091 2 compliance compliance NN cord-335975-m6lkrehi 4091 3 of of IN cord-335975-m6lkrehi 4091 4 the the DT cord-335975-m6lkrehi 4091 5 IVC IVC NNP cord-335975-m6lkrehi 4091 6 was be VBD cord-335975-m6lkrehi 4091 7 estimated estimate VBN cord-335975-m6lkrehi 4091 8 by by IN cord-335975-m6lkrehi 4091 9 the the DT cord-335975-m6lkrehi 4091 10 ratio ratio NN cord-335975-m6lkrehi 4091 11 ( ( -LRB- cord-335975-m6lkrehi 4091 12 end end NN cord-335975-m6lkrehi 4091 13 - - HYPH cord-335975-m6lkrehi 4091 14 expiratory expiratory NN cord-335975-m6lkrehi 4091 15 - - HYPH cord-335975-m6lkrehi 4091 16 end end NN cord-335975-m6lkrehi 4091 17 - - HYPH cord-335975-m6lkrehi 4091 18 inspiratory inspiratory JJ cord-335975-m6lkrehi 4091 19 IVC IVC NNP cord-335975-m6lkrehi 4091 20 diameter diameter NN cord-335975-m6lkrehi 4091 21 ) ) -RRB- cord-335975-m6lkrehi 4092 1 ( ( -LRB- cord-335975-m6lkrehi 4092 2 end end NN cord-335975-m6lkrehi 4092 3 - - HYPH cord-335975-m6lkrehi 4092 4 expiratoryend expiratoryend NN cord-335975-m6lkrehi 4092 5 - - HYPH cord-335975-m6lkrehi 4092 6 inspiratory inspiratory JJ cord-335975-m6lkrehi 4092 7 CVP CVP NNP cord-335975-m6lkrehi 4092 8 ) ) -RRB- cord-335975-m6lkrehi 4092 9 . . . cord-335975-m6lkrehi 4093 1 Results result NNS cord-335975-m6lkrehi 4093 2 : : : cord-335975-m6lkrehi 4094 1 Fluid fluid JJ cord-335975-m6lkrehi 4094 2 administration administration NN cord-335975-m6lkrehi 4094 3 increased increase VBD cord-335975-m6lkrehi 4094 4 cardiac cardiac JJ cord-335975-m6lkrehi 4094 5 index index NN cord-335975-m6lkrehi 4094 6 by by IN cord-335975-m6lkrehi 4094 7 more more JJR cord-335975-m6lkrehi 4094 8 than than IN cord-335975-m6lkrehi 4094 9 15 15 CD cord-335975-m6lkrehi 4094 10 % % NN cord-335975-m6lkrehi 4094 11 ( ( -LRB- cord-335975-m6lkrehi 4094 12 3.09 3.09 CD cord-335975-m6lkrehi 4094 13 ± ± NNP cord-335975-m6lkrehi 4094 14 1.12 1.12 CD cord-335975-m6lkrehi 4094 15 to to IN cord-335975-m6lkrehi 4094 16 3.90 3.90 CD cord-335975-m6lkrehi 4095 1 ± ± CD cord-335975-m6lkrehi 4095 2 1.42 1.42 CD cord-335975-m6lkrehi 4096 1 L L NNP cord-335975-m6lkrehi 4096 2 min min NNP cord-335975-m6lkrehi 4096 3 m m NNP cord-335975-m6lkrehi 4096 4 2 2 CD cord-335975-m6lkrehi 4096 5 , , , cord-335975-m6lkrehi 4096 6 p p NN cord-335975-m6lkrehi 4096 7 = = SYM cord-335975-m6lkrehi 4096 8 0.0003 0.0003 CD cord-335975-m6lkrehi 4096 9 ) ) -RRB- cord-335975-m6lkrehi 4096 10 in in IN cord-335975-m6lkrehi 4096 11 8 8 CD cord-335975-m6lkrehi 4096 12 patients patient NNS cord-335975-m6lkrehi 4096 13 . . . cord-335975-m6lkrehi 4097 1 The the DT cord-335975-m6lkrehi 4097 2 respiratory respiratory JJ cord-335975-m6lkrehi 4097 3 variations variation NNS cord-335975-m6lkrehi 4097 4 of of IN cord-335975-m6lkrehi 4097 5 the the DT cord-335975-m6lkrehi 4097 6 IVC IVC NNP cord-335975-m6lkrehi 4097 7 diameter diameter NN cord-335975-m6lkrehi 4097 8 predicted predict VBN cord-335975-m6lkrehi 4097 9 fluid fluid JJ cord-335975-m6lkrehi 4097 10 responsiveness responsiveness NN cord-335975-m6lkrehi 4097 11 ( ( -LRB- cord-335975-m6lkrehi 4097 12 area area NN cord-335975-m6lkrehi 4097 13 under under IN cord-335975-m6lkrehi 4097 14 the the DT cord-335975-m6lkrehi 4097 15 ROC ROC NNP cord-335975-m6lkrehi 4097 16 curve-0.822 curve-0.822 NNP cord-335975-m6lkrehi 4098 1 ( ( -LRB- cord-335975-m6lkrehi 4098 2 95 95 CD cord-335975-m6lkrehi 4098 3 % % NN cord-335975-m6lkrehi 4098 4 CI CI NNP cord-335975-m6lkrehi 4098 5 0.595 0.595 CD cord-335975-m6lkrehi 4098 6 - - HYPH cord-335975-m6lkrehi 4098 7 0.952 0.952 CD cord-335975-m6lkrehi 4098 8 ) ) -RRB- cord-335975-m6lkrehi 4098 9 , , , cord-335975-m6lkrehi 4098 10 p p NN cord-335975-m6lkrehi 4098 11 < < XX cord-335975-m6lkrehi 4098 12 0.05 0.05 CD cord-335975-m6lkrehi 4098 13 ) ) -RRB- cord-335975-m6lkrehi 4098 14 . . . cord-335975-m6lkrehi 4099 1 Before before IN cord-335975-m6lkrehi 4099 2 fluid fluid JJ cord-335975-m6lkrehi 4099 3 administration administration NN cord-335975-m6lkrehi 4099 4 , , , cord-335975-m6lkrehi 4099 5 the the DT cord-335975-m6lkrehi 4099 6 ratio ratio NN cord-335975-m6lkrehi 4099 7 of of IN cord-335975-m6lkrehi 4099 8 changes change NNS cord-335975-m6lkrehi 4099 9 in in IN cord-335975-m6lkrehi 4099 10 IVC IVC NNP cord-335975-m6lkrehi 4099 11 diameter diameter NN cord-335975-m6lkrehi 4099 12 over over IN cord-335975-m6lkrehi 4099 13 changes change NNS cord-335975-m6lkrehi 4099 14 in in IN cord-335975-m6lkrehi 4099 15 CVP CVP NNP cord-335975-m6lkrehi 4099 16 was be VBD cord-335975-m6lkrehi 4099 17 not not RB cord-335975-m6lkrehi 4099 18 different different JJ cord-335975-m6lkrehi 4099 19 between between IN cord-335975-m6lkrehi 4099 20 responders responder NNS cord-335975-m6lkrehi 4099 21 and and CC cord-335975-m6lkrehi 4099 22 non non NNS cord-335975-m6lkrehi 4099 23 - - NNS cord-335975-m6lkrehi 4099 24 responders responder NNS cord-335975-m6lkrehi 4099 25 ( ( -LRB- cord-335975-m6lkrehi 4099 26 0.73 0.73 CD cord-335975-m6lkrehi 4099 27 ± ± CD cord-335975-m6lkrehi 4099 28 0.34 0.34 CD cord-335975-m6lkrehi 4099 29 vs. vs. NN cord-335975-m6lkrehi 4099 30 0.88 0.88 CD cord-335975-m6lkrehi 4099 31 ± ± CD cord-335975-m6lkrehi 4099 32 1.25 1.25 CD cord-335975-m6lkrehi 4099 33 mm mm NN cord-335975-m6lkrehi 4099 34 mmHg mmhg NN cord-335975-m6lkrehi 4099 35 , , , cord-335975-m6lkrehi 4099 36 p p NN cord-335975-m6lkrehi 4099 37 = = SYM cord-335975-m6lkrehi 4099 38 0.75 0.75 CD cord-335975-m6lkrehi 4099 39 ) ) -RRB- cord-335975-m6lkrehi 4099 40 . . . cord-335975-m6lkrehi 4100 1 Before before IN cord-335975-m6lkrehi 4100 2 fluid fluid JJ cord-335975-m6lkrehi 4100 3 administration administration NN cord-335975-m6lkrehi 4100 4 , , , cord-335975-m6lkrehi 4100 5 the the DT cord-335975-m6lkrehi 4100 6 respiratory respiratory JJ cord-335975-m6lkrehi 4100 7 variations variation NNS cord-335975-m6lkrehi 4100 8 of of IN cord-335975-m6lkrehi 4100 9 the the DT cord-335975-m6lkrehi 4100 10 CVP CVP NNP cord-335975-m6lkrehi 4100 11 tended tend VBD cord-335975-m6lkrehi 4100 12 to to TO cord-335975-m6lkrehi 4100 13 be be VB cord-335975-m6lkrehi 4100 14 higher high JJR cord-335975-m6lkrehi 4100 15 in in IN cord-335975-m6lkrehi 4100 16 responders responder NNS cord-335975-m6lkrehi 4100 17 than than IN cord-335975-m6lkrehi 4100 18 in in IN cord-335975-m6lkrehi 4100 19 non non NNS cord-335975-m6lkrehi 4100 20 - - NNS cord-335975-m6lkrehi 4100 21 responders responder NNS cord-335975-m6lkrehi 4101 1 ( ( -LRB- cord-335975-m6lkrehi 4101 2 34 34 CD cord-335975-m6lkrehi 4101 3 ± ± CD cord-335975-m6lkrehi 4101 4 27 27 CD cord-335975-m6lkrehi 4101 5 vs. vs. NN cord-335975-m6lkrehi 4101 6 18 18 CD cord-335975-m6lkrehi 4101 7 ± ± CD cord-335975-m6lkrehi 4101 8 8 8 CD cord-335975-m6lkrehi 4101 9 % % NN cord-335975-m6lkrehi 4101 10 , , , cord-335975-m6lkrehi 4101 11 p p NN cord-335975-m6lkrehi 4101 12 = = SYM cord-335975-m6lkrehi 4101 13 0.07 0.07 CD cord-335975-m6lkrehi 4101 14 ) ) -RRB- cord-335975-m6lkrehi 4101 15 . . . cord-335975-m6lkrehi 4102 1 The the DT cord-335975-m6lkrehi 4102 2 respiratory respiratory JJ cord-335975-m6lkrehi 4102 3 variations variation NNS cord-335975-m6lkrehi 4102 4 of of IN cord-335975-m6lkrehi 4102 5 the the DT cord-335975-m6lkrehi 4102 6 IVC IVC NNP cord-335975-m6lkrehi 4102 7 diameter diameter NN cord-335975-m6lkrehi 4102 8 were be VBD cord-335975-m6lkrehi 4102 9 associated associate VBN cord-335975-m6lkrehi 4102 10 with with IN cord-335975-m6lkrehi 4102 11 the the DT cord-335975-m6lkrehi 4102 12 respiratory respiratory JJ cord-335975-m6lkrehi 4102 13 variations variation NNS cord-335975-m6lkrehi 4102 14 of of IN cord-335975-m6lkrehi 4102 15 CVP CVP NNP cord-335975-m6lkrehi 4102 16 ( ( -LRB- cord-335975-m6lkrehi 4102 17 r r NN cord-335975-m6lkrehi 4102 18 = = SYM cord-335975-m6lkrehi 4102 19 0.56 0.56 CD cord-335975-m6lkrehi 4102 20 , , , cord-335975-m6lkrehi 4102 21 p p NN cord-335975-m6lkrehi 4102 22 = = SYM cord-335975-m6lkrehi 4102 23 0.01 0.01 CD cord-335975-m6lkrehi 4102 24 ) ) -RRB- cord-335975-m6lkrehi 4102 25 but but CC cord-335975-m6lkrehi 4102 26 not not RB cord-335975-m6lkrehi 4102 27 with with IN cord-335975-m6lkrehi 4102 28 the the DT cord-335975-m6lkrehi 4102 29 respiratory respiratory JJ cord-335975-m6lkrehi 4102 30 variations variation NNS cord-335975-m6lkrehi 4102 31 of of IN cord-335975-m6lkrehi 4102 32 IAP IAP NNP cord-335975-m6lkrehi 4102 33 ( ( -LRB- cord-335975-m6lkrehi 4102 34 r r NN cord-335975-m6lkrehi 4102 35 = = SYM cord-335975-m6lkrehi 4102 36 -0.15 -0.15 NN cord-335975-m6lkrehi 4102 37 , , , cord-335975-m6lkrehi 4102 38 p p NN cord-335975-m6lkrehi 4102 39 = = SYM cord-335975-m6lkrehi 4102 40 0.52 0.52 CD cord-335975-m6lkrehi 4102 41 ) ) -RRB- cord-335975-m6lkrehi 4102 42 . . . cord-335975-m6lkrehi 4103 1 The the DT cord-335975-m6lkrehi 4103 2 respiratory respiratory JJ cord-335975-m6lkrehi 4103 3 variations variation NNS cord-335975-m6lkrehi 4103 4 of of IN cord-335975-m6lkrehi 4103 5 the the DT cord-335975-m6lkrehi 4103 6 IVC IVC NNP cord-335975-m6lkrehi 4103 7 diameter diameter NN cord-335975-m6lkrehi 4103 8 were be VBD cord-335975-m6lkrehi 4103 9 not not RB cord-335975-m6lkrehi 4103 10 explained explain VBN cord-335975-m6lkrehi 4103 11 by by IN cord-335975-m6lkrehi 4103 12 a a DT cord-335975-m6lkrehi 4103 13 higher high JJR cord-335975-m6lkrehi 4103 14 IVC IVC NNP cord-335975-m6lkrehi 4103 15 compliance compliance NN cord-335975-m6lkrehi 4103 16 but but CC cord-335975-m6lkrehi 4103 17 rather rather RB cord-335975-m6lkrehi 4103 18 by by IN cord-335975-m6lkrehi 4103 19 higher high JJR cord-335975-m6lkrehi 4103 20 respiratory respiratory JJ cord-335975-m6lkrehi 4103 21 variations variation NNS cord-335975-m6lkrehi 4103 22 of of IN cord-335975-m6lkrehi 4103 23 the the DT cord-335975-m6lkrehi 4103 24 CVP CVP NNP cord-335975-m6lkrehi 4103 25 in in IN cord-335975-m6lkrehi 4103 26 responders responder NNS cord-335975-m6lkrehi 4103 27 than than IN cord-335975-m6lkrehi 4103 28 in in IN cord-335975-m6lkrehi 4103 29 non non NNS cord-335975-m6lkrehi 4103 30 - - NNS cord-335975-m6lkrehi 4103 31 responders responder NNS cord-335975-m6lkrehi 4103 32 . . . cord-335975-m6lkrehi 4104 1 Interestingly interestingly RB cord-335975-m6lkrehi 4104 2 , , , cord-335975-m6lkrehi 4104 3 it -PRON- PRP cord-335975-m6lkrehi 4104 4 seems seem VBZ cord-335975-m6lkrehi 4104 5 that that IN cord-335975-m6lkrehi 4104 6 IAP IAP NNP cord-335975-m6lkrehi 4104 7 , , , cord-335975-m6lkrehi 4104 8 the the DT cord-335975-m6lkrehi 4104 9 IVC IVC NNP cord-335975-m6lkrehi 4104 10 extramural extramural JJ cord-335975-m6lkrehi 4104 11 pressure pressure NN cord-335975-m6lkrehi 4104 12 , , , cord-335975-m6lkrehi 4104 13 was be VBD cord-335975-m6lkrehi 4104 14 not not RB cord-335975-m6lkrehi 4104 15 involved involve VBN cord-335975-m6lkrehi 4104 16 in in IN cord-335975-m6lkrehi 4104 17 the the DT cord-335975-m6lkrehi 4104 18 respiratory respiratory JJ cord-335975-m6lkrehi 4104 19 variations variation NNS cord-335975-m6lkrehi 4104 20 of of IN cord-335975-m6lkrehi 4104 21 the the DT cord-335975-m6lkrehi 4104 22 IVC IVC NNP cord-335975-m6lkrehi 4104 23 diameter diameter NN cord-335975-m6lkrehi 4104 24 . . . cord-335975-m6lkrehi 4105 1 Inclusions inclusion NNS cord-335975-m6lkrehi 4105 2 are be VBP cord-335975-m6lkrehi 4105 3 ongoing ongoing JJ cord-335975-m6lkrehi 4105 4 . . . cord-335975-m6lkrehi 4106 1 During during IN cord-335975-m6lkrehi 4106 2 the the DT cord-335975-m6lkrehi 4106 3 hospitalization hospitalization NN cord-335975-m6lkrehi 4106 4 in in IN cord-335975-m6lkrehi 4106 5 ICU ICU NNP cord-335975-m6lkrehi 4106 6 , , , cord-335975-m6lkrehi 4106 7 there there EX cord-335975-m6lkrehi 4106 8 was be VBD cord-335975-m6lkrehi 4106 9 no no DT cord-335975-m6lkrehi 4106 10 significant significant JJ cord-335975-m6lkrehi 4106 11 difference difference NN cord-335975-m6lkrehi 4106 12 between between IN cord-335975-m6lkrehi 4106 13 the the DT cord-335975-m6lkrehi 4106 14 two two CD cord-335975-m6lkrehi 4106 15 groups group NNS cord-335975-m6lkrehi 4106 16 regarding regard VBG cord-335975-m6lkrehi 4106 17 the the DT cord-335975-m6lkrehi 4106 18 proportion proportion NN cord-335975-m6lkrehi 4106 19 of of IN cord-335975-m6lkrehi 4106 20 patients patient NNS cord-335975-m6lkrehi 4106 21 with with IN cord-335975-m6lkrehi 4106 22 AKI AKI NNP cord-335975-m6lkrehi 4106 23 through through IN cord-335975-m6lkrehi 4106 24 ICU ICU NNP cord-335975-m6lkrehi 4106 25 discharge discharge NN cord-335975-m6lkrehi 4106 26 . . . cord-335975-m6lkrehi 4107 1 In in IN cord-335975-m6lkrehi 4107 2 the the DT cord-335975-m6lkrehi 4107 3 intervention intervention NN cord-335975-m6lkrehi 4107 4 group group NN cord-335975-m6lkrehi 4107 5 , , , cord-335975-m6lkrehi 4107 6 28 28 CD cord-335975-m6lkrehi 4107 7 % % NN cord-335975-m6lkrehi 4107 8 of of IN cord-335975-m6lkrehi 4107 9 the the DT cord-335975-m6lkrehi 4107 10 patients patient NNS cord-335975-m6lkrehi 4107 11 had have VBD cord-335975-m6lkrehi 4107 12 a a DT cord-335975-m6lkrehi 4107 13 glomerular glomerular JJ cord-335975-m6lkrehi 4107 14 filtration filtration NN cord-335975-m6lkrehi 4107 15 rate rate NN cord-335975-m6lkrehi 4107 16 lower low JJR cord-335975-m6lkrehi 4107 17 than than IN cord-335975-m6lkrehi 4107 18 75 75 CD cord-335975-m6lkrehi 4107 19 mL ml NN cord-335975-m6lkrehi 4107 20 min min NN cord-335975-m6lkrehi 4107 21 1.73 1.73 CD cord-335975-m6lkrehi 4107 22 m m NN cord-335975-m6lkrehi 4107 23 2 2 CD cord-335975-m6lkrehi 4107 24 compared compare VBN cord-335975-m6lkrehi 4107 25 to to IN cord-335975-m6lkrehi 4107 26 14.8 14.8 CD cord-335975-m6lkrehi 4107 27 % % NN cord-335975-m6lkrehi 4107 28 in in IN cord-335975-m6lkrehi 4107 29 the the DT cord-335975-m6lkrehi 4107 30 control control NN cord-335975-m6lkrehi 4107 31 group group NN cord-335975-m6lkrehi 4107 32 ( ( -LRB- cord-335975-m6lkrehi 4107 33 p p NN cord-335975-m6lkrehi 4107 34 = = SYM cord-335975-m6lkrehi 4107 35 0.25 0.25 CD cord-335975-m6lkrehi 4107 36 ) ) -RRB- cord-335975-m6lkrehi 4107 37 at at IN cord-335975-m6lkrehi 4107 38 day-28 day-28 NNP cord-335975-m6lkrehi 4107 39 . . . cord-335975-m6lkrehi 4108 1 We -PRON- PRP cord-335975-m6lkrehi 4108 2 found find VBD cord-335975-m6lkrehi 4108 3 no no DT cord-335975-m6lkrehi 4108 4 significant significant JJ cord-335975-m6lkrehi 4108 5 difference difference NN cord-335975-m6lkrehi 4108 6 between between IN cord-335975-m6lkrehi 4108 7 the the DT cord-335975-m6lkrehi 4108 8 two two CD cord-335975-m6lkrehi 4108 9 groups group NNS cord-335975-m6lkrehi 4108 10 neither neither CC cord-335975-m6lkrehi 4108 11 on on IN cord-335975-m6lkrehi 4108 12 hematopoietic hematopoietic JJ cord-335975-m6lkrehi 4108 13 effects effect NNS cord-335975-m6lkrehi 4108 14 of of IN cord-335975-m6lkrehi 4108 15 Epo Epo NNP cord-335975-m6lkrehi 4108 16 or or CC cord-335975-m6lkrehi 4108 17 serious serious JJ cord-335975-m6lkrehi 4108 18 adverse adverse JJ cord-335975-m6lkrehi 4108 19 events event NNS cord-335975-m6lkrehi 4108 20 . . . cord-335975-m6lkrehi 4109 1 In in IN cord-335975-m6lkrehi 4109 2 patients patient NNS cord-335975-m6lkrehi 4109 3 resuscitated resuscitate VBN cord-335975-m6lkrehi 4109 4 from from IN cord-335975-m6lkrehi 4109 5 an an DT cord-335975-m6lkrehi 4109 6 OHCA OHCA NNP cord-335975-m6lkrehi 4109 7 of of IN cord-335975-m6lkrehi 4109 8 presumed presume VBN cord-335975-m6lkrehi 4109 9 cardiac cardiac NN cord-335975-m6lkrehi 4109 10 cause cause NN cord-335975-m6lkrehi 4109 11 , , , cord-335975-m6lkrehi 4109 12 early early JJ cord-335975-m6lkrehi 4109 13 administration administration NN cord-335975-m6lkrehi 4109 14 of of IN cord-335975-m6lkrehi 4109 15 erythropoietin erythropoietin NN cord-335975-m6lkrehi 4109 16 compared compare VBN cord-335975-m6lkrehi 4109 17 to to IN cord-335975-m6lkrehi 4109 18 standard standard JJ cord-335975-m6lkrehi 4109 19 therapy therapy NN cord-335975-m6lkrehi 4109 20 did do VBD cord-335975-m6lkrehi 4109 21 not not RB cord-335975-m6lkrehi 4109 22 confer confer VB cord-335975-m6lkrehi 4109 23 any any DT cord-335975-m6lkrehi 4109 24 renal renal JJ cord-335975-m6lkrehi 4109 25 protective protective JJ cord-335975-m6lkrehi 4109 26 effect effect NN cord-335975-m6lkrehi 4109 27 . . . cord-335975-m6lkrehi 4110 1 Salvetti Salvetti NNP cord-335975-m6lkrehi 4110 2 Marie Marie NNP cord-335975-m6lkrehi 4110 3 , , , cord-335975-m6lkrehi 4110 4 and and CC cord-335975-m6lkrehi 4110 5 the the DT cord-335975-m6lkrehi 4110 6 ratio ratio NN cord-335975-m6lkrehi 4110 7 of of IN cord-335975-m6lkrehi 4110 8 end end NN cord-335975-m6lkrehi 4110 9 - - HYPH cord-335975-m6lkrehi 4110 10 diastolic diastolic JJ cord-335975-m6lkrehi 4110 11 areas area NNS cord-335975-m6lkrehi 4110 12 of of IN cord-335975-m6lkrehi 4110 13 both both CC cord-335975-m6lkrehi 4110 14 the the DT cord-335975-m6lkrehi 4110 15 right right NN cord-335975-m6lkrehi 4110 16 and and CC cord-335975-m6lkrehi 4110 17 left left JJ cord-335975-m6lkrehi 4110 18 ventricle ventricle NN cord-335975-m6lkrehi 4110 19 in in IN cord-335975-m6lkrehi 4110 20 the the DT cord-335975-m6lkrehi 4110 21 long long JJ cord-335975-m6lkrehi 4110 22 axis axis NN cord-335975-m6lkrehi 4110 23 view view NN cord-335975-m6lkrehi 4110 24 of of IN cord-335975-m6lkrehi 4110 25 the the DT cord-335975-m6lkrehi 4110 26 heart heart NN cord-335975-m6lkrehi 4110 27 ( ( -LRB- cord-335975-m6lkrehi 4110 28 RVEDA RVEDA NNP cord-335975-m6lkrehi 4110 29 LVEDA LVEDA NNP cord-335975-m6lkrehi 4110 30 ) ) -RRB- cord-335975-m6lkrehi 4110 31 were be VBD cord-335975-m6lkrehi 4110 32 measured measure VBN cord-335975-m6lkrehi 4110 33 . . . cord-335975-m6lkrehi 4111 1 A a DT cord-335975-m6lkrehi 4111 2 LVEF LVEF NNP cord-335975-m6lkrehi 4111 3 < < XX cord-335975-m6lkrehi 4111 4 40 40 CD cord-335975-m6lkrehi 4111 5 % % NN cord-335975-m6lkrehi 4111 6 defined define VBN cord-335975-m6lkrehi 4111 7 LV LV NNP cord-335975-m6lkrehi 4111 8 systolic systolic JJ cord-335975-m6lkrehi 4111 9 dysfunction dysfunction NN cord-335975-m6lkrehi 4111 10 , , , cord-335975-m6lkrehi 4111 11 a a DT cord-335975-m6lkrehi 4111 12 CI ci NN cord-335975-m6lkrehi 4111 13 < < XX cord-335975-m6lkrehi 4111 14 3 3 CD cord-335975-m6lkrehi 4111 15 l l NN cord-335975-m6lkrehi 4111 16 min min NN cord-335975-m6lkrehi 4111 17 m m NN cord-335975-m6lkrehi 4111 18 2 2 CD cord-335975-m6lkrehi 4111 19 defined define VBD cord-335975-m6lkrehi 4111 20 low low JJ cord-335975-m6lkrehi 4111 21 cardiac cardiac JJ cord-335975-m6lkrehi 4111 22 output output NN cord-335975-m6lkrehi 4111 23 , , , cord-335975-m6lkrehi 4111 24 and and CC cord-335975-m6lkrehi 4111 25 a a DT cord-335975-m6lkrehi 4111 26 RVEDA RVEDA NNP cord-335975-m6lkrehi 4111 27 LVEDA LVEDA NNP cord-335975-m6lkrehi 4111 28 ratio ratio NN cord-335975-m6lkrehi 4111 29 > > XX cord-335975-m6lkrehi 4111 30 0.6 0.6 CD cord-335975-m6lkrehi 4112 1 ( ( -LRB- cord-335975-m6lkrehi 4112 2 ± ± NNP cord-335975-m6lkrehi 4112 3 associated associate VBN cord-335975-m6lkrehi 4112 4 with with IN cord-335975-m6lkrehi 4112 5 a a DT cord-335975-m6lkrehi 4112 6 paradoxical paradoxical JJ cord-335975-m6lkrehi 4112 7 septal septal JJ cord-335975-m6lkrehi 4112 8 motion motion NN cord-335975-m6lkrehi 4112 9 in in IN cord-335975-m6lkrehi 4112 10 the the DT cord-335975-m6lkrehi 4112 11 short short JJ cord-335975-m6lkrehi 4112 12 axis axis NN cord-335975-m6lkrehi 4112 13 of of IN cord-335975-m6lkrehi 4112 14 the the DT cord-335975-m6lkrehi 4112 15 heart heart NN cord-335975-m6lkrehi 4112 16 ) ) -RRB- cord-335975-m6lkrehi 4112 17 defined define VBD cord-335975-m6lkrehi 4112 18 RV RV NNP cord-335975-m6lkrehi 4112 19 dysfunction dysfunction NN cord-335975-m6lkrehi 4112 20 ( ( -LRB- cord-335975-m6lkrehi 4112 21 ± ± NNP cord-335975-m6lkrehi 4112 22 acute acute JJ cord-335975-m6lkrehi 4112 23 cor cor NNP cord-335975-m6lkrehi 4112 24 pulmonale pulmonale NN cord-335975-m6lkrehi 4112 25 ) ) -RRB- cord-335975-m6lkrehi 4112 26 . . . cord-335975-m6lkrehi 4113 1 The the DT cord-335975-m6lkrehi 4113 2 preload preload NN cord-335975-m6lkrehi 4113 3 - - HYPH cord-335975-m6lkrehi 4113 4 dependence dependence NN cord-335975-m6lkrehi 4113 5 was be VBD cord-335975-m6lkrehi 4113 6 evaluated evaluate VBN cord-335975-m6lkrehi 4113 7 using use VBG cord-335975-m6lkrehi 4113 8 deltaSVC deltaSVC NNP cord-335975-m6lkrehi 4113 9 or or CC cord-335975-m6lkrehi 4113 10 deltaVmaxAo deltaVmaxAo NNS cord-335975-m6lkrehi 4113 11 . . . cord-335975-m6lkrehi 4114 1 Front front JJ cord-335975-m6lkrehi 4114 2 - - HYPH cord-335975-m6lkrehi 4114 3 line line NN cord-335975-m6lkrehi 4114 4 hemodynamic hemodynamic JJ cord-335975-m6lkrehi 4114 5 and and CC cord-335975-m6lkrehi 4114 6 metabolic metabolic JJ cord-335975-m6lkrehi 4114 7 parameters parameter NNS cord-335975-m6lkrehi 4114 8 were be VBD cord-335975-m6lkrehi 4114 9 recorded record VBN cord-335975-m6lkrehi 4114 10 at at IN cord-335975-m6lkrehi 4114 11 the the DT cord-335975-m6lkrehi 4114 12 time time NN cord-335975-m6lkrehi 4114 13 of of IN cord-335975-m6lkrehi 4114 14 TEE tee NN cord-335975-m6lkrehi 4114 15 assessment assessment NN cord-335975-m6lkrehi 4114 16 . . . cord-335975-m6lkrehi 4115 1 Results result NNS cord-335975-m6lkrehi 4115 2 : : : cord-335975-m6lkrehi 4116 1 LVEF LVEF NNP cord-335975-m6lkrehi 4116 2 and and CC cord-335975-m6lkrehi 4116 3 CI CI NNP cord-335975-m6lkrehi 4116 4 could could MD cord-335975-m6lkrehi 4116 5 be be VB cord-335975-m6lkrehi 4116 6 simultaneously simultaneously RB cord-335975-m6lkrehi 4116 7 measured measure VBN cord-335975-m6lkrehi 4116 8 in in IN cord-335975-m6lkrehi 4116 9 388 388 CD cord-335975-m6lkrehi 4116 10 of of IN cord-335975-m6lkrehi 4116 11 410 410 CD cord-335975-m6lkrehi 4116 12 patients patient NNS cord-335975-m6lkrehi 4116 13 ( ( -LRB- cord-335975-m6lkrehi 4116 14 95 95 CD cord-335975-m6lkrehi 4116 15 % % NN cord-335975-m6lkrehi 4116 16 ) ) -RRB- cord-335975-m6lkrehi 4116 17 . . . cord-335975-m6lkrehi 4117 1 74 74 CD cord-335975-m6lkrehi 4117 2 patients patient NNS cord-335975-m6lkrehi 4117 3 ( ( -LRB- cord-335975-m6lkrehi 4117 4 19 19 CD cord-335975-m6lkrehi 4117 5 % % NN cord-335975-m6lkrehi 4117 6 ) ) -RRB- cord-335975-m6lkrehi 4117 7 had have VBD cord-335975-m6lkrehi 4117 8 a a DT cord-335975-m6lkrehi 4117 9 low low JJ cord-335975-m6lkrehi 4117 10 CI ci NN cord-335975-m6lkrehi 4117 11 related relate VBN cord-335975-m6lkrehi 4117 12 to to IN cord-335975-m6lkrehi 4117 13 LV LV NNP cord-335975-m6lkrehi 4117 14 systolic systolic JJ cord-335975-m6lkrehi 4117 15 dysfunction dysfunction NN cord-335975-m6lkrehi 4117 16 ( ( -LRB- cord-335975-m6lkrehi 4117 17 lactate-4.36 lactate-4.36 NNP cord-335975-m6lkrehi 4117 18 ± ± NNP cord-335975-m6lkrehi 4117 19 3.49 3.49 CD cord-335975-m6lkrehi 4117 20 mmol mmol JJ cord-335975-m6lkrehi 4117 21 l l NNP cord-335975-m6lkrehi 4117 22 ) ) -RRB- cord-335975-m6lkrehi 4117 23 , , , cord-335975-m6lkrehi 4117 24 141 141 CD cord-335975-m6lkrehi 4117 25 patients patient NNS cord-335975-m6lkrehi 4117 26 ( ( -LRB- cord-335975-m6lkrehi 4117 27 36 36 CD cord-335975-m6lkrehi 4117 28 % % NN cord-335975-m6lkrehi 4117 29 ) ) -RRB- cord-335975-m6lkrehi 4117 30 had have VBD cord-335975-m6lkrehi 4117 31 a a DT cord-335975-m6lkrehi 4117 32 low low JJ cord-335975-m6lkrehi 4117 33 CI ci NN cord-335975-m6lkrehi 4117 34 and and CC cord-335975-m6lkrehi 4117 35 a a DT cord-335975-m6lkrehi 4117 36 preserved preserve VBN cord-335975-m6lkrehi 4117 37 LVEF LVEF NNP cord-335975-m6lkrehi 4117 38 related relate VBN cord-335975-m6lkrehi 4117 39 to to IN cord-335975-m6lkrehi 4117 40 a a DT cord-335975-m6lkrehi 4117 41 RV RV NNP cord-335975-m6lkrehi 4117 42 dysfunction dysfunction NN cord-335975-m6lkrehi 4117 43 or or CC cord-335975-m6lkrehi 4117 44 to to IN cord-335975-m6lkrehi 4117 45 a a DT cord-335975-m6lkrehi 4117 46 sustained sustained JJ cord-335975-m6lkrehi 4117 47 preload preload NN cord-335975-m6lkrehi 4117 48 - - HYPH cord-335975-m6lkrehi 4117 49 dependence dependence NN cord-335975-m6lkrehi 4117 50 ( ( -LRB- cord-335975-m6lkrehi 4117 51 lactate-3.58 lactate-3.58 NN cord-335975-m6lkrehi 4117 52 ± ± NNP cord-335975-m6lkrehi 4117 53 3.28 3.28 CD cord-335975-m6lkrehi 4117 54 mmol mmol JJ cord-335975-m6lkrehi 4117 55 l l NN cord-335975-m6lkrehi 4117 56 ) ) -RRB- cord-335975-m6lkrehi 4117 57 , , , cord-335975-m6lkrehi 4117 58 146 146 CD cord-335975-m6lkrehi 4117 59 patients patient NNS cord-335975-m6lkrehi 4117 60 ( ( -LRB- cord-335975-m6lkrehi 4117 61 38 38 CD cord-335975-m6lkrehi 4117 62 % % NN cord-335975-m6lkrehi 4117 63 ) ) -RRB- cord-335975-m6lkrehi 4117 64 had have VBD cord-335975-m6lkrehi 4117 65 preserved preserve VBN cord-335975-m6lkrehi 4117 66 CI CI NNP cord-335975-m6lkrehi 4117 67 and and CC cord-335975-m6lkrehi 4117 68 LVEF LVEF NNP cord-335975-m6lkrehi 4118 1 ( ( -LRB- cord-335975-m6lkrehi 4118 2 lactate-3.38 lactate-3.38 NNP cord-335975-m6lkrehi 4118 3 ± ± CD cord-335975-m6lkrehi 4118 4 3.32 3.32 CD cord-335975-m6lkrehi 4118 5 mmol mmol JJ cord-335975-m6lkrehi 4118 6 l l NN cord-335975-m6lkrehi 4118 7 ) ) -RRB- cord-335975-m6lkrehi 4118 8 including include VBG cord-335975-m6lkrehi 4118 9 only only RB cord-335975-m6lkrehi 4118 10 23 23 CD cord-335975-m6lkrehi 4118 11 patients patient NNS cord-335975-m6lkrehi 4118 12 ( ( -LRB- cord-335975-m6lkrehi 4118 13 6 6 CD cord-335975-m6lkrehi 4118 14 % % NN cord-335975-m6lkrehi 4118 15 ) ) -RRB- cord-335975-m6lkrehi 4118 16 with with IN cord-335975-m6lkrehi 4118 17 a a DT cord-335975-m6lkrehi 4118 18 hyperkinetic hyperkinetic JJ cord-335975-m6lkrehi 4118 19 profile profile NN cord-335975-m6lkrehi 4118 20 ( ( -LRB- cord-335975-m6lkrehi 4118 21 high high JJ cord-335975-m6lkrehi 4118 22 CI CI NNP cord-335975-m6lkrehi 4118 23 and and CC cord-335975-m6lkrehi 4118 24 LVEF LVEF NNP cord-335975-m6lkrehi 4118 25 > > XX cord-335975-m6lkrehi 4118 26 70 70 CD cord-335975-m6lkrehi 4118 27 % % NN cord-335975-m6lkrehi 4118 28 ) ) -RRB- cord-335975-m6lkrehi 4118 29 , , , cord-335975-m6lkrehi 4118 30 and and CC cord-335975-m6lkrehi 4118 31 27 27 CD cord-335975-m6lkrehi 4118 32 patients patient NNS cord-335975-m6lkrehi 4118 33 ( ( -LRB- cord-335975-m6lkrehi 4118 34 7 7 CD cord-335975-m6lkrehi 4118 35 % % NN cord-335975-m6lkrehi 4118 36 ) ) -RRB- cord-335975-m6lkrehi 4118 37 had have VBD cord-335975-m6lkrehi 4118 38 preserved preserve VBN cord-335975-m6lkrehi 4118 39 CI CI NNP cord-335975-m6lkrehi 4118 40 but but CC cord-335975-m6lkrehi 4118 41 altered alter VBD cord-335975-m6lkrehi 4118 42 LVEF LVEF NNP cord-335975-m6lkrehi 4118 43 ( ( -LRB- cord-335975-m6lkrehi 4118 44 lactate-3.49 lactate-3.49 NNP cord-335975-m6lkrehi 4118 45 ± ± CD cord-335975-m6lkrehi 4118 46 2.95 2.95 CD cord-335975-m6lkrehi 4118 47 mmol mmol JJ cord-335975-m6lkrehi 4118 48 l l NN cord-335975-m6lkrehi 4118 49 ) ) -RRB- cord-335975-m6lkrehi 4118 50 due due IN cord-335975-m6lkrehi 4118 51 to to IN cord-335975-m6lkrehi 4118 52 a a DT cord-335975-m6lkrehi 4118 53 marked marked JJ cord-335975-m6lkrehi 4118 54 tachycardia tachycardia NN cord-335975-m6lkrehi 4118 55 . . . cord-335975-m6lkrehi 4119 1 None none NN cord-335975-m6lkrehi 4119 2 of of IN cord-335975-m6lkrehi 4119 3 the the DT cord-335975-m6lkrehi 4119 4 front front JJ cord-335975-m6lkrehi 4119 5 - - HYPH cord-335975-m6lkrehi 4119 6 line line NN cord-335975-m6lkrehi 4119 7 hemodynamic hemodynamic JJ cord-335975-m6lkrehi 4119 8 parameters parameter NNS cord-335975-m6lkrehi 4119 9 was be VBD cord-335975-m6lkrehi 4119 10 discriminatory discriminatory JJ cord-335975-m6lkrehi 4119 11 to to TO cord-335975-m6lkrehi 4119 12 identify identify VB cord-335975-m6lkrehi 4119 13 the the DT cord-335975-m6lkrehi 4119 14 circulatory circulatory JJ cord-335975-m6lkrehi 4119 15 profile profile NN cord-335975-m6lkrehi 4119 16 identified identify VBN cord-335975-m6lkrehi 4119 17 by by IN cord-335975-m6lkrehi 4119 18 TEE tee NN cord-335975-m6lkrehi 4119 19 assessment assessment NN cord-335975-m6lkrehi 4119 20 ( ( -LRB- cord-335975-m6lkrehi 4119 21 Table table NN cord-335975-m6lkrehi 4119 22 ) ) -RRB- cord-335975-m6lkrehi 4119 23 . . . cord-335975-m6lkrehi 4120 1 Introduction introduction NN cord-335975-m6lkrehi 4120 2 : : : cord-335975-m6lkrehi 4121 1 Aortic aortic JJ cord-335975-m6lkrehi 4121 2 end end NN cord-335975-m6lkrehi 4121 3 - - HYPH cord-335975-m6lkrehi 4121 4 systolic systolic JJ cord-335975-m6lkrehi 4121 5 pressure pressure NN cord-335975-m6lkrehi 4121 6 ( ( -LRB- cord-335975-m6lkrehi 4121 7 ESP ESP NNP cord-335975-m6lkrehi 4121 8 ) ) -RRB- cord-335975-m6lkrehi 4121 9 is be VBZ cord-335975-m6lkrehi 4121 10 considered consider VBN cord-335975-m6lkrehi 4121 11 as as IN cord-335975-m6lkrehi 4121 12 a a DT cord-335975-m6lkrehi 4121 13 reliable reliable JJ cord-335975-m6lkrehi 4121 14 index index NN cord-335975-m6lkrehi 4121 15 of of IN cord-335975-m6lkrehi 4121 16 left left JJ cord-335975-m6lkrehi 4121 17 ventricular ventricular JJ cord-335975-m6lkrehi 4121 18 afterload afterload NN cord-335975-m6lkrehi 4121 19 . . . cord-335975-m6lkrehi 4122 1 Recently recently RB cord-335975-m6lkrehi 4122 2 , , , cord-335975-m6lkrehi 4122 3 the the DT cord-335975-m6lkrehi 4122 4 effective effective JJ cord-335975-m6lkrehi 4122 5 arterial arterial JJ cord-335975-m6lkrehi 4122 6 elastance elastance NN cord-335975-m6lkrehi 4122 7 ( ( -LRB- cord-335975-m6lkrehi 4122 8 Ea Ea NNP cord-335975-m6lkrehi 4122 9 ) ) -RRB- cord-335975-m6lkrehi 4122 10 , , , cord-335975-m6lkrehi 4122 11 i.e. i.e. FW cord-335975-m6lkrehi 4122 12 , , , cord-335975-m6lkrehi 4122 13 the the DT cord-335975-m6lkrehi 4122 14 ratio ratio NN cord-335975-m6lkrehi 4122 15 of of IN cord-335975-m6lkrehi 4122 16 ESP ESP NNP cord-335975-m6lkrehi 4122 17 over over IN cord-335975-m6lkrehi 4122 18 stroke stroke NN cord-335975-m6lkrehi 4122 19 volume volume NN cord-335975-m6lkrehi 4122 20 ( ( -LRB- cord-335975-m6lkrehi 4122 21 SV SV NNP cord-335975-m6lkrehi 4122 22 ) ) -RRB- cord-335975-m6lkrehi 4122 23 , , , cord-335975-m6lkrehi 4122 24 has have VBZ cord-335975-m6lkrehi 4122 25 also also RB cord-335975-m6lkrehi 4122 26 been be VBN cord-335975-m6lkrehi 4122 27 proposed propose VBN cord-335975-m6lkrehi 4122 28 as as IN cord-335975-m6lkrehi 4122 29 a a DT cord-335975-m6lkrehi 4122 30 reliable reliable JJ cord-335975-m6lkrehi 4122 31 afterload afterload NN cord-335975-m6lkrehi 4122 32 index index NN cord-335975-m6lkrehi 4122 33 . . . cord-335975-m6lkrehi 4123 1 Our -PRON- PRP$ cord-335975-m6lkrehi 4123 2 aim aim NN cord-335975-m6lkrehi 4123 3 was be VBD cord-335975-m6lkrehi 4123 4 to to TO cord-335975-m6lkrehi 4123 5 document document VB cord-335975-m6lkrehi 4123 6 peripheral peripheral JJ cord-335975-m6lkrehi 4123 7 estimates estimate NNS cord-335975-m6lkrehi 4123 8 of of IN cord-335975-m6lkrehi 4123 9 Ea Ea NNP cord-335975-m6lkrehi 4123 10 ( ( -LRB- cord-335975-m6lkrehi 4123 11 EapSAP EapSAP NNP cord-335975-m6lkrehi 4123 12 ) ) -RRB- cord-335975-m6lkrehi 4123 13 at at IN cord-335975-m6lkrehi 4123 14 the the DT cord-335975-m6lkrehi 4123 15 bedside bedside NN cord-335975-m6lkrehi 4123 16 in in IN cord-335975-m6lkrehi 4123 17 critically critically RB cord-335975-m6lkrehi 4123 18 ill ill JJ cord-335975-m6lkrehi 4123 19 patients patient NNS cord-335975-m6lkrehi 4123 20 , , , cord-335975-m6lkrehi 4123 21 and and CC cord-335975-m6lkrehi 4123 22 to to TO cord-335975-m6lkrehi 4123 23 investigate investigate VB cord-335975-m6lkrehi 4123 24 the the DT cord-335975-m6lkrehi 4123 25 haemodynamic haemodynamic NNP cord-335975-m6lkrehi 4123 26 mechanisms mechanism NNS cord-335975-m6lkrehi 4123 27 responsible responsible JJ cord-335975-m6lkrehi 4123 28 for for IN cord-335975-m6lkrehi 4123 29 Ea Ea NNP cord-335975-m6lkrehi 4123 30 changes change NNS cord-335975-m6lkrehi 4123 31 after after IN cord-335975-m6lkrehi 4123 32 fluid fluid JJ cord-335975-m6lkrehi 4123 33 administration administration NN cord-335975-m6lkrehi 4123 34 ( ( -LRB- cord-335975-m6lkrehi 4123 35 FA FA NNP cord-335975-m6lkrehi 4123 36 ) ) -RRB- cord-335975-m6lkrehi 4123 37 . . . cord-335975-m6lkrehi 4124 1 In in IN cord-335975-m6lkrehi 4124 2 the the DT cord-335975-m6lkrehi 4124 3 validation validation NN cord-335975-m6lkrehi 4124 4 study study NN cord-335975-m6lkrehi 4124 5 , , , cord-335975-m6lkrehi 4124 6 carotid carotid NNP cord-335975-m6lkrehi 4124 7 tonometry tonometry NNP cord-335975-m6lkrehi 4124 8 ( ( -LRB- cord-335975-m6lkrehi 4124 9 Complior Complior NNP cord-335975-m6lkrehi 4124 10 ) ) -RRB- cord-335975-m6lkrehi 4124 11 was be VBD cord-335975-m6lkrehi 4124 12 prospectively prospectively RB cord-335975-m6lkrehi 4124 13 performed perform VBN cord-335975-m6lkrehi 4124 14 on on IN cord-335975-m6lkrehi 4124 15 50 50 CD cord-335975-m6lkrehi 4124 16 haemodynamically haemodynamically RB cord-335975-m6lkrehi 4124 17 stable stable JJ cord-335975-m6lkrehi 4124 18 spontaneously spontaneously RB cord-335975-m6lkrehi 4124 19 breathing breathe VBG cord-335975-m6lkrehi 4124 20 patients patient NNS cord-335975-m6lkrehi 4124 21 equipped equip VBN cord-335975-m6lkrehi 4124 22 with with IN cord-335975-m6lkrehi 4124 23 an an DT cord-335975-m6lkrehi 4124 24 arterial arterial JJ cord-335975-m6lkrehi 4124 25 femoral femoral NN cord-335975-m6lkrehi 4124 26 ( ( -LRB- cord-335975-m6lkrehi 4124 27 n n NN cord-335975-m6lkrehi 4124 28 = = SYM cord-335975-m6lkrehi 4124 29 21 21 CD cord-335975-m6lkrehi 4124 30 ) ) -RRB- cord-335975-m6lkrehi 4124 31 or or CC cord-335975-m6lkrehi 4124 32 radial radial JJ cord-335975-m6lkrehi 4124 33 ( ( -LRB- cord-335975-m6lkrehi 4124 34 n n NN cord-335975-m6lkrehi 4124 35 = = SYM cord-335975-m6lkrehi 4124 36 29 29 CD cord-335975-m6lkrehi 4124 37 ) ) -RRB- cord-335975-m6lkrehi 4124 38 catheter catheter NN cord-335975-m6lkrehi 4124 39 . . . cord-335975-m6lkrehi 4125 1 Ea Ea NNP cord-335975-m6lkrehi 4125 2 was be VBD cord-335975-m6lkrehi 4125 3 defined define VBN cord-335975-m6lkrehi 4125 4 as as IN cord-335975-m6lkrehi 4125 5 the the DT cord-335975-m6lkrehi 4125 6 ( ( -LRB- cord-335975-m6lkrehi 4125 7 0.9 0.9 CD cord-335975-m6lkrehi 4125 8 × × NN cord-335975-m6lkrehi 4125 9 cSAP csap NN cord-335975-m6lkrehi 4125 10 ) ) -RRB- cord-335975-m6lkrehi 4125 11 SV sv NN cord-335975-m6lkrehi 4125 12 ratio ratio NN cord-335975-m6lkrehi 4125 13 , , , cord-335975-m6lkrehi 4125 14 where where WRB cord-335975-m6lkrehi 4125 15 cSAP cSAP NNP cord-335975-m6lkrehi 4125 16 was be VBD cord-335975-m6lkrehi 4125 17 the the DT cord-335975-m6lkrehi 4125 18 central central JJ cord-335975-m6lkrehi 4125 19 systolic systolic JJ cord-335975-m6lkrehi 4125 20 arterial arterial JJ cord-335975-m6lkrehi 4125 21 pressure pressure NN cord-335975-m6lkrehi 4125 22 directly directly RB cord-335975-m6lkrehi 4125 23 measured measure VBN cord-335975-m6lkrehi 4125 24 from from IN cord-335975-m6lkrehi 4125 25 the the DT cord-335975-m6lkrehi 4125 26 calibrated calibrate VBN cord-335975-m6lkrehi 4125 27 carotid carotid NN cord-335975-m6lkrehi 4125 28 waveform waveform NN cord-335975-m6lkrehi 4125 29 . . . cord-335975-m6lkrehi 4126 1 EapSAP EapSAP NNP cord-335975-m6lkrehi 4126 2 was be VBD cord-335975-m6lkrehi 4126 3 calculated calculate VBN cord-335975-m6lkrehi 4126 4 as as IN cord-335975-m6lkrehi 4126 5 the the DT cord-335975-m6lkrehi 4126 6 ( ( -LRB- cord-335975-m6lkrehi 4126 7 0.9 0.9 CD cord-335975-m6lkrehi 4126 8 x x SYM cord-335975-m6lkrehi 4126 9 peripheral peripheral JJ cord-335975-m6lkrehi 4126 10 systolic systolic JJ cord-335975-m6lkrehi 4126 11 arterial arterial JJ cord-335975-m6lkrehi 4126 12 pressure pressure NN cord-335975-m6lkrehi 4126 13 ) ) -RRB- cord-335975-m6lkrehi 4126 14 SV sv NN cord-335975-m6lkrehi 4126 15 ratio ratio NN cord-335975-m6lkrehi 4126 16 . . . cord-335975-m6lkrehi 4127 1 SV SV NNP cord-335975-m6lkrehi 4127 2 was be VBD cord-335975-m6lkrehi 4127 3 obtained obtain VBN cord-335975-m6lkrehi 4127 4 by by IN cord-335975-m6lkrehi 4127 5 transpulmonary transpulmonary NNP cord-335975-m6lkrehi 4127 6 thermodilution thermodilution NN cord-335975-m6lkrehi 4127 7 or or CC cord-335975-m6lkrehi 4127 8 transthoracic transthoracic NNP cord-335975-m6lkrehi 4127 9 echocardiography echocardiography NN cord-335975-m6lkrehi 4127 10 . . . cord-335975-m6lkrehi 4128 1 In in IN cord-335975-m6lkrehi 4128 2 the the DT cord-335975-m6lkrehi 4128 3 clinical clinical JJ cord-335975-m6lkrehi 4128 4 study study NN cord-335975-m6lkrehi 4128 5 , , , cord-335975-m6lkrehi 4128 6 we -PRON- PRP cord-335975-m6lkrehi 4128 7 included include VBD cord-335975-m6lkrehi 4128 8 30 30 CD cord-335975-m6lkrehi 4128 9 patients patient NNS cord-335975-m6lkrehi 4128 10 with with IN cord-335975-m6lkrehi 4128 11 invasive invasive JJ cord-335975-m6lkrehi 4128 12 haemodynamic haemodynamic JJ cord-335975-m6lkrehi 4128 13 monitoring monitoring NN cord-335975-m6lkrehi 4128 14 ( ( -LRB- cord-335975-m6lkrehi 4128 15 PiCCO-2 picco-2 NN cord-335975-m6lkrehi 4128 16 ) ) -RRB- cord-335975-m6lkrehi 4128 17 , , , cord-335975-m6lkrehi 4128 18 in in IN cord-335975-m6lkrehi 4128 19 whom whom WP cord-335975-m6lkrehi 4128 20 FA FA NNP cord-335975-m6lkrehi 4128 21 was be VBD cord-335975-m6lkrehi 4128 22 planned plan VBN cord-335975-m6lkrehi 4128 23 . . . cord-335975-m6lkrehi 4129 1 Results result NNS cord-335975-m6lkrehi 4129 2 : : : cord-335975-m6lkrehi 4130 1 In in IN cord-335975-m6lkrehi 4130 2 the the DT cord-335975-m6lkrehi 4130 3 validation validation NN cord-335975-m6lkrehi 4130 4 study study NN cord-335975-m6lkrehi 4130 5 , , , cord-335975-m6lkrehi 4130 6 the the DT cord-335975-m6lkrehi 4130 7 Complior Complior NNP cord-335975-m6lkrehi 4130 8 allowed allow VBD cord-335975-m6lkrehi 4130 9 estimating estimate VBG cord-335975-m6lkrehi 4130 10 Ea Ea NNP cord-335975-m6lkrehi 4130 11 in in IN cord-335975-m6lkrehi 4130 12 all all DT cord-335975-m6lkrehi 4130 13 patients patient NNS cord-335975-m6lkrehi 4130 14 ( ( -LRB- cord-335975-m6lkrehi 4130 15 Ea Ea NNP cord-335975-m6lkrehi 4130 16 = = NN cord-335975-m6lkrehi 4130 17 1.73 1.73 CD cord-335975-m6lkrehi 4130 18 ± ± CD cord-335975-m6lkrehi 4130 19 0.62 0.62 CD cord-335975-m6lkrehi 4130 20 mmHg mmHg NNS cord-335975-m6lkrehi 4130 21 mL mL NNP cord-335975-m6lkrehi 4130 22 ) ) -RRB- cord-335975-m6lkrehi 4130 23 . . . cord-335975-m6lkrehi 4131 1 The the DT cord-335975-m6lkrehi 4131 2 ( ( -LRB- cord-335975-m6lkrehi 4131 3 EapSAP EapSAP NNP cord-335975-m6lkrehi 4131 4 - - HYPH cord-335975-m6lkrehi 4131 5 Ea Ea NNP cord-335975-m6lkrehi 4131 6 ) ) -RRB- cord-335975-m6lkrehi 4131 7 bias bias NN cord-335975-m6lkrehi 4131 8 was be VBD cord-335975-m6lkrehi 4131 9 smaller small JJR cord-335975-m6lkrehi 4131 10 at at IN cord-335975-m6lkrehi 4131 11 the the DT cord-335975-m6lkrehi 4131 12 femoral femoral NN cord-335975-m6lkrehi 4131 13 than than IN cord-335975-m6lkrehi 4131 14 radial radial JJ cord-335975-m6lkrehi 4131 15 artery artery NN cord-335975-m6lkrehi 4131 16 level level NN cord-335975-m6lkrehi 4131 17 ( ( -LRB- cord-335975-m6lkrehi 4131 18 0.08 0.08 CD cord-335975-m6lkrehi 4131 19 ± ± CD cord-335975-m6lkrehi 4131 20 0.08 0.08 CD cord-335975-m6lkrehi 4131 21 vs. vs. NN cord-335975-m6lkrehi 4131 22 0.18 0.18 CD cord-335975-m6lkrehi 4131 23 ± ± CD cord-335975-m6lkrehi 4131 24 0.16 0.16 CD cord-335975-m6lkrehi 4131 25 mmHg mmHg NNS cord-335975-m6lkrehi 4131 26 mL ml NN cord-335975-m6lkrehi 4131 27 , , , cord-335975-m6lkrehi 4131 28 p p NN cord-335975-m6lkrehi 4131 29 < < XX cord-335975-m6lkrehi 4131 30 0.05 0.05 CD cord-335975-m6lkrehi 4131 31 ) ) -RRB- cord-335975-m6lkrehi 4131 32 and and CC cord-335975-m6lkrehi 4131 33 was be VBD cord-335975-m6lkrehi 4131 34 strongly strongly RB cord-335975-m6lkrehi 4131 35 related relate VBN cord-335975-m6lkrehi 4131 36 to to IN cord-335975-m6lkrehi 4131 37 the the DT cord-335975-m6lkrehi 4131 38 systolic systolic JJ cord-335975-m6lkrehi 4131 39 pressure pressure NN cord-335975-m6lkrehi 4131 40 amplification amplification NN cord-335975-m6lkrehi 4131 41 between between IN cord-335975-m6lkrehi 4131 42 the the DT cord-335975-m6lkrehi 4131 43 carotid carotid JJ cord-335975-m6lkrehi 4131 44 and and CC cord-335975-m6lkrehi 4131 45 peripheral peripheral JJ cord-335975-m6lkrehi 4131 46 artery artery NN cord-335975-m6lkrehi 4131 47 ( ( -LRB- cord-335975-m6lkrehi 4131 48 r r NN cord-335975-m6lkrehi 4131 49 = = SYM cord-335975-m6lkrehi 4131 50 0.89 0.89 CD cord-335975-m6lkrehi 4131 51 , , , cord-335975-m6lkrehi 4131 52 p p NN cord-335975-m6lkrehi 4131 53 < < XX cord-335975-m6lkrehi 4131 54 0.05 0.05 CD cord-335975-m6lkrehi 4131 55 ) ) -RRB- cord-335975-m6lkrehi 4131 56 . . . cord-335975-m6lkrehi 4132 1 Ea Ea NNP cord-335975-m6lkrehi 4132 2 was be VBD cord-335975-m6lkrehi 4132 3 more more RBR cord-335975-m6lkrehi 4132 4 strongly strongly RB cord-335975-m6lkrehi 4132 5 related related JJ cord-335975-m6lkrehi 4132 6 to to IN cord-335975-m6lkrehi 4132 7 SV SV NNP cord-335975-m6lkrehi 4132 8 ( ( -LRB- cord-335975-m6lkrehi 4132 9 r r NN cord-335975-m6lkrehi 4132 10 = = NN cord-335975-m6lkrehi 4132 11 − − CD cord-335975-m6lkrehi 4132 12 0.80 0.80 CD cord-335975-m6lkrehi 4132 13 ) ) -RRB- cord-335975-m6lkrehi 4133 1 than than IN cord-335975-m6lkrehi 4133 2 to to IN cord-335975-m6lkrehi 4133 3 ESP ESP NNP cord-335975-m6lkrehi 4133 4 ( ( -LRB- cord-335975-m6lkrehi 4133 5 r r NN cord-335975-m6lkrehi 4133 6 = = SYM cord-335975-m6lkrehi 4133 7 0.48 0.48 CD cord-335975-m6lkrehi 4133 8 ) ) -RRB- cord-335975-m6lkrehi 4133 9 ( ( -LRB- cord-335975-m6lkrehi 4133 10 each each DT cord-335975-m6lkrehi 4133 11 p p NN cord-335975-m6lkrehi 4133 12 < < XX cord-335975-m6lkrehi 4133 13 0.05 0.05 CD cord-335975-m6lkrehi 4133 14 ) ) -RRB- cord-335975-m6lkrehi 4133 15 . . . cord-335975-m6lkrehi 4134 1 The the DT cord-335975-m6lkrehi 4134 2 four four CD cord-335975-m6lkrehi 4134 3 - - HYPH cord-335975-m6lkrehi 4134 4 quadrant quadrant JJ cord-335975-m6lkrehi 4134 5 plot plot NN cord-335975-m6lkrehi 4134 6 analysis analysis NN cord-335975-m6lkrehi 4134 7 indicated indicate VBD cord-335975-m6lkrehi 4134 8 that that IN cord-335975-m6lkrehi 4134 9 47 47 CD cord-335975-m6lkrehi 4134 10 patients patient NNS cord-335975-m6lkrehi 4134 11 ( ( -LRB- cord-335975-m6lkrehi 4134 12 94 94 CD cord-335975-m6lkrehi 4134 13 % % NN cord-335975-m6lkrehi 4134 14 ) ) -RRB- cord-335975-m6lkrehi 4134 15 exhibited exhibit VBD cord-335975-m6lkrehi 4134 16 a a DT cord-335975-m6lkrehi 4134 17 concordant concordant JJ cord-335975-m6lkrehi 4134 18 low low JJ cord-335975-m6lkrehi 4134 19 Ea Ea NNP cord-335975-m6lkrehi 4134 20 high high JJ cord-335975-m6lkrehi 4134 21 SV sv NN cord-335975-m6lkrehi 4134 22 pattern pattern NN cord-335975-m6lkrehi 4134 23 or or CC cord-335975-m6lkrehi 4134 24 high high JJ cord-335975-m6lkrehi 4134 25 Ea Ea NNP cord-335975-m6lkrehi 4134 26 low low JJ cord-335975-m6lkrehi 4134 27 SV sv NN cord-335975-m6lkrehi 4134 28 pattern pattern NN cord-335975-m6lkrehi 4134 29 , , , cord-335975-m6lkrehi 4134 30 while while IN cord-335975-m6lkrehi 4134 31 only only RB cord-335975-m6lkrehi 4134 32 33 33 CD cord-335975-m6lkrehi 4134 33 patients patient NNS cord-335975-m6lkrehi 4134 34 ( ( -LRB- cord-335975-m6lkrehi 4134 35 66 66 CD cord-335975-m6lkrehi 4134 36 % % NN cord-335975-m6lkrehi 4134 37 ) ) -RRB- cord-335975-m6lkrehi 4134 38 exhibited exhibit VBD cord-335975-m6lkrehi 4134 39 concordant concordant JJ cord-335975-m6lkrehi 4134 40 high high JJ cord-335975-m6lkrehi 4134 41 Ea Ea NNP cord-335975-m6lkrehi 4134 42 high high JJ cord-335975-m6lkrehi 4134 43 ESP esp NN cord-335975-m6lkrehi 4134 44 pattern pattern NN cord-335975-m6lkrehi 4134 45 or or CC cord-335975-m6lkrehi 4134 46 low low JJ cord-335975-m6lkrehi 4134 47 Ea Ea NNP cord-335975-m6lkrehi 4134 48 low low JJ cord-335975-m6lkrehi 4134 49 ESP ESP NNP cord-335975-m6lkrehi 4134 50 pattern pattern NN cord-335975-m6lkrehi 4134 51 ( ( -LRB- cord-335975-m6lkrehi 4134 52 p p NN cord-335975-m6lkrehi 4134 53 < < XX cord-335975-m6lkrehi 4134 54 0.05 0.05 CD cord-335975-m6lkrehi 4134 55 ) ) -RRB- cord-335975-m6lkrehi 4134 56 . . . cord-335975-m6lkrehi 4135 1 There there EX cord-335975-m6lkrehi 4135 2 was be VBD cord-335975-m6lkrehi 4135 3 a a DT cord-335975-m6lkrehi 4135 4 negative negative JJ cord-335975-m6lkrehi 4135 5 relationship relationship NN cord-335975-m6lkrehi 4135 6 between between IN cord-335975-m6lkrehi 4135 7 changes change NNS cord-335975-m6lkrehi 4135 8 in in IN cord-335975-m6lkrehi 4135 9 EapSAP EapSAP NNS cord-335975-m6lkrehi 4135 10 and and CC cord-335975-m6lkrehi 4135 11 changes change NNS cord-335975-m6lkrehi 4135 12 in in IN cord-335975-m6lkrehi 4135 13 SV SV NNP cord-335975-m6lkrehi 4135 14 in in IN cord-335975-m6lkrehi 4135 15 the the DT cord-335975-m6lkrehi 4135 16 whole whole JJ cord-335975-m6lkrehi 4135 17 population population NN cord-335975-m6lkrehi 4135 18 , , , cord-335975-m6lkrehi 4135 19 in in IN cord-335975-m6lkrehi 4135 20 fluid fluid JJ cord-335975-m6lkrehi 4135 21 responders responder NNS cord-335975-m6lkrehi 4135 22 ( ( -LRB- cord-335975-m6lkrehi 4135 23 cardiac cardiac JJ cord-335975-m6lkrehi 4135 24 index index NN cord-335975-m6lkrehi 4135 25 increases increase VBZ cord-335975-m6lkrehi 4135 26 > > XX cord-335975-m6lkrehi 4135 27 15 15 CD cord-335975-m6lkrehi 4135 28 % % NN cord-335975-m6lkrehi 4135 29 after after IN cord-335975-m6lkrehi 4135 30 FA FA NNP cord-335975-m6lkrehi 4135 31 ) ) -RRB- cord-335975-m6lkrehi 4135 32 , , , cord-335975-m6lkrehi 4135 33 in in IN cord-335975-m6lkrehi 4135 34 pressure pressure NN cord-335975-m6lkrehi 4135 35 responders responder NNS cord-335975-m6lkrehi 4135 36 ( ( -LRB- cord-335975-m6lkrehi 4135 37 mean mean VB cord-335975-m6lkrehi 4135 38 arterial arterial JJ cord-335975-m6lkrehi 4135 39 pressure pressure NN cord-335975-m6lkrehi 4135 40 increases increase NNS cord-335975-m6lkrehi 4135 41 > > XX cord-335975-m6lkrehi 4135 42 10 10 CD cord-335975-m6lkrehi 4135 43 % % NN cord-335975-m6lkrehi 4135 44 after after IN cord-335975-m6lkrehi 4135 45 FA FA NNP cord-335975-m6lkrehi 4135 46 ) ) -RRB- cord-335975-m6lkrehi 4135 47 and and CC cord-335975-m6lkrehi 4135 48 in in IN cord-335975-m6lkrehi 4135 49 non non NNS cord-335975-m6lkrehi 4135 50 - - NNS cord-335975-m6lkrehi 4135 51 responders responder NNS cord-335975-m6lkrehi 4135 52 , , , cord-335975-m6lkrehi 4135 53 while while IN cord-335975-m6lkrehi 4135 54 no no DT cord-335975-m6lkrehi 4135 55 consistent consistent JJ cord-335975-m6lkrehi 4135 56 relationship relationship NN cord-335975-m6lkrehi 4135 57 between between IN cord-335975-m6lkrehi 4135 58 EapSAP EapSAP NNS cord-335975-m6lkrehi 4135 59 and and CC cord-335975-m6lkrehi 4135 60 ESP ESP NNP cord-335975-m6lkrehi 4135 61 changes change NNS cord-335975-m6lkrehi 4135 62 was be VBD cord-335975-m6lkrehi 4135 63 documented document VBN cord-335975-m6lkrehi 4135 64 . . . cord-335975-m6lkrehi 4136 1 Conclusion conclusion NN cord-335975-m6lkrehi 4136 2 : : : cord-335975-m6lkrehi 4137 1 Ea Ea NNP cord-335975-m6lkrehi 4137 2 may may MD cord-335975-m6lkrehi 4137 3 be be VB cord-335975-m6lkrehi 4137 4 reliably reliably RB cord-335975-m6lkrehi 4137 5 estimated estimate VBN cord-335975-m6lkrehi 4137 6 at at IN cord-335975-m6lkrehi 4137 7 bedside bedside NN cord-335975-m6lkrehi 4137 8 by by IN cord-335975-m6lkrehi 4137 9 using use VBG cord-335975-m6lkrehi 4137 10 the the DT cord-335975-m6lkrehi 4137 11 ( ( -LRB- cord-335975-m6lkrehi 4137 12 0.9 0.9 CD cord-335975-m6lkrehi 4137 13 x x NN cord-335975-m6lkrehi 4137 14 femoralSAP femoralSAP NNP cord-335975-m6lkrehi 4137 15 ) ) -RRB- cord-335975-m6lkrehi 4137 16 SV sv NN cord-335975-m6lkrehi 4137 17 ratio ratio NN cord-335975-m6lkrehi 4137 18 . . . cord-335975-m6lkrehi 4138 1 Ea Ea NNP cord-335975-m6lkrehi 4138 2 value value NN cord-335975-m6lkrehi 4138 3 and and CC cord-335975-m6lkrehi 4138 4 Ea Ea NNP cord-335975-m6lkrehi 4138 5 changes change NNS cord-335975-m6lkrehi 4138 6 induced induce VBN cord-335975-m6lkrehi 4138 7 by by IN cord-335975-m6lkrehi 4138 8 FA FA NNP cord-335975-m6lkrehi 4138 9 were be VBD cord-335975-m6lkrehi 4138 10 related relate VBN cord-335975-m6lkrehi 4138 11 to to IN cord-335975-m6lkrehi 4138 12 SV SV NNP cord-335975-m6lkrehi 4138 13 rather rather RB cord-335975-m6lkrehi 4138 14 than than IN cord-335975-m6lkrehi 4138 15 to to IN cord-335975-m6lkrehi 4138 16 ESP ESP NNP cord-335975-m6lkrehi 4138 17 . . . cord-335975-m6lkrehi 4139 1 Thus thus RB cord-335975-m6lkrehi 4139 2 , , , cord-335975-m6lkrehi 4139 3 Ea Ea NNP cord-335975-m6lkrehi 4139 4 should should MD cord-335975-m6lkrehi 4139 5 be be VB cord-335975-m6lkrehi 4139 6 considered consider VBN cord-335975-m6lkrehi 4139 7 as as IN cord-335975-m6lkrehi 4139 8 an an DT cord-335975-m6lkrehi 4139 9 index index NN cord-335975-m6lkrehi 4139 10 reflecting reflect VBG cord-335975-m6lkrehi 4139 11 SV SV NNP cord-335975-m6lkrehi 4139 12 rather rather RB cord-335975-m6lkrehi 4139 13 than than IN cord-335975-m6lkrehi 4139 14 left leave VBN cord-335975-m6lkrehi 4139 15 ventricular ventricular JJ cord-335975-m6lkrehi 4139 16 afterload afterload NN cord-335975-m6lkrehi 4139 17 in in IN cord-335975-m6lkrehi 4139 18 critically critically RB cord-335975-m6lkrehi 4139 19 ill ill JJ cord-335975-m6lkrehi 4139 20 patients patient NNS cord-335975-m6lkrehi 4139 21 . . . cord-335975-m6lkrehi 4139 22 _SP cord-335975-m6lkrehi 4140 1 This this DT cord-335975-m6lkrehi 4140 2 study study NN cord-335975-m6lkrehi 4140 3 included include VBD cord-335975-m6lkrehi 4140 4 a a DT cord-335975-m6lkrehi 4140 5 Sham Sham NNP cord-335975-m6lkrehi 4140 6 group group NN cord-335975-m6lkrehi 4140 7 ( ( -LRB- cord-335975-m6lkrehi 4140 8 n n NN cord-335975-m6lkrehi 4140 9 = = SYM cord-335975-m6lkrehi 4140 10 11 11 CD cord-335975-m6lkrehi 4140 11 ) ) -RRB- cord-335975-m6lkrehi 4140 12 , , , cord-335975-m6lkrehi 4140 13 a a DT cord-335975-m6lkrehi 4140 14 CPB CPB NNP cord-335975-m6lkrehi 4140 15 group group NN cord-335975-m6lkrehi 4140 16 ( ( -LRB- cord-335975-m6lkrehi 4140 17 n n NN cord-335975-m6lkrehi 4140 18 = = SYM cord-335975-m6lkrehi 4140 19 9 9 CD cord-335975-m6lkrehi 4140 20 ) ) -RRB- cord-335975-m6lkrehi 4140 21 , , , cord-335975-m6lkrehi 4140 22 an an DT cord-335975-m6lkrehi 4140 23 IR IR NNP cord-335975-m6lkrehi 4140 24 group group NN cord-335975-m6lkrehi 4140 25 ( ( -LRB- cord-335975-m6lkrehi 4140 26 n n NN cord-335975-m6lkrehi 4140 27 = = SYM cord-335975-m6lkrehi 4140 28 8) 8) NN cord-335975-m6lkrehi 4140 29 and and CC cord-335975-m6lkrehi 4140 30 a a DT cord-335975-m6lkrehi 4140 31 CPB CPB NNP cord-335975-m6lkrehi 4140 32 - - HYPH cord-335975-m6lkrehi 4140 33 IR IR NNP cord-335975-m6lkrehi 4140 34 group group NN cord-335975-m6lkrehi 4140 35 ( ( -LRB- cord-335975-m6lkrehi 4140 36 n n NN cord-335975-m6lkrehi 4140 37 = = SYM cord-335975-m6lkrehi 4140 38 11 11 CD cord-335975-m6lkrehi 4140 39 ) ) -RRB- cord-335975-m6lkrehi 4140 40 . . . cord-335975-m6lkrehi 4141 1 Rats rat NNS cord-335975-m6lkrehi 4141 2 were be VBD cord-335975-m6lkrehi 4141 3 exposed expose VBN cord-335975-m6lkrehi 4141 4 to to IN cord-335975-m6lkrehi 4141 5 45 45 CD cord-335975-m6lkrehi 4141 6 min min NN cord-335975-m6lkrehi 4141 7 of of IN cord-335975-m6lkrehi 4141 8 CEC CEC NNP cord-335975-m6lkrehi 4141 9 , , , cord-335975-m6lkrehi 4141 10 30 30 CD cord-335975-m6lkrehi 4141 11 min min NN cord-335975-m6lkrehi 4141 12 of of IN cord-335975-m6lkrehi 4141 13 left left JJ cord-335975-m6lkrehi 4141 14 pulmonary pulmonary JJ cord-335975-m6lkrehi 4141 15 ischemia ischemia NN cord-335975-m6lkrehi 4141 16 and and CC cord-335975-m6lkrehi 4141 17 15 15 CD cord-335975-m6lkrehi 4141 18 min min NN cord-335975-m6lkrehi 4141 19 of of IN cord-335975-m6lkrehi 4141 20 reperfusion reperfusion NN cord-335975-m6lkrehi 4141 21 . . . cord-335975-m6lkrehi 4142 1 Fonctional Fonctional NNP cord-335975-m6lkrehi 4142 2 endothelial endothelial JJ cord-335975-m6lkrehi 4142 3 dysfunction dysfunction NN cord-335975-m6lkrehi 4142 4 was be VBD cord-335975-m6lkrehi 4142 5 evaluated evaluate VBN cord-335975-m6lkrehi 4142 6 by by IN cord-335975-m6lkrehi 4142 7 measurement measurement NN cord-335975-m6lkrehi 4142 8 of of IN cord-335975-m6lkrehi 4142 9 the the DT cord-335975-m6lkrehi 4142 10 pulmonary pulmonary JJ cord-335975-m6lkrehi 4142 11 artery artery NN cord-335975-m6lkrehi 4142 12 reactivity reactivity NN cord-335975-m6lkrehi 4142 13 . . . cord-335975-m6lkrehi 4143 1 Systemic systemic JJ cord-335975-m6lkrehi 4143 2 inflammation inflammation NN cord-335975-m6lkrehi 4143 3 was be VBD cord-335975-m6lkrehi 4143 4 evaluated evaluate VBN cord-335975-m6lkrehi 4143 5 by by IN cord-335975-m6lkrehi 4143 6 the the DT cord-335975-m6lkrehi 4143 7 plasma plasma NN cord-335975-m6lkrehi 4143 8 assay assay NN cord-335975-m6lkrehi 4143 9 of of IN cord-335975-m6lkrehi 4143 10 IL-1 IL-1 NNP cord-335975-m6lkrehi 4143 11 beta beta NN cord-335975-m6lkrehi 4143 12 , , , cord-335975-m6lkrehi 4143 13 IL-10 IL-10 NNP cord-335975-m6lkrehi 4143 14 and and CC cord-335975-m6lkrehi 4143 15 TNF TNF NNP cord-335975-m6lkrehi 4143 16 - - HYPH cord-335975-m6lkrehi 4143 17 alpha alpha NN cord-335975-m6lkrehi 4143 18 . . . cord-335975-m6lkrehi 4144 1 The the DT cord-335975-m6lkrehi 4144 2 endothelial endothelial JJ cord-335975-m6lkrehi 4144 3 glycocalyx glycocalyx NN cord-335975-m6lkrehi 4144 4 was be VBD cord-335975-m6lkrehi 4144 5 evaluated evaluate VBN cord-335975-m6lkrehi 4144 6 by by IN cord-335975-m6lkrehi 4144 7 plasma plasma NN cord-335975-m6lkrehi 4144 8 assay assay NN cord-335975-m6lkrehi 4144 9 syndecan-1 syndecan-1 NNP cord-335975-m6lkrehi 4144 10 and and CC cord-335975-m6lkrehi 4144 11 electron electron NN cord-335975-m6lkrehi 4144 12 microscopy microscopy NN cord-335975-m6lkrehi 4144 13 . . . cord-335975-m6lkrehi 4145 1 The the DT cord-335975-m6lkrehi 4145 2 statistics statistic NNS cord-335975-m6lkrehi 4145 3 were be VBD cord-335975-m6lkrehi 4145 4 performed perform VBN cord-335975-m6lkrehi 4145 5 using use VBG cord-335975-m6lkrehi 4145 6 an an DT cord-335975-m6lkrehi 4145 7 ANOVA ANOVA NNP cord-335975-m6lkrehi 4145 8 test test NN cord-335975-m6lkrehi 4145 9 , , , cord-335975-m6lkrehi 4145 10 p p NN cord-335975-m6lkrehi 4145 11 < < XX cord-335975-m6lkrehi 4145 12 0.05 0.05 CD cord-335975-m6lkrehi 4145 13 . . . cord-335975-m6lkrehi 4146 1 We -PRON- PRP cord-335975-m6lkrehi 4146 2 showed show VBD cord-335975-m6lkrehi 4146 3 that that IN cord-335975-m6lkrehi 4146 4 CPB CPB NNP cord-335975-m6lkrehi 4146 5 associated associate VBN cord-335975-m6lkrehi 4146 6 with with IN cord-335975-m6lkrehi 4146 7 IR IR NNP cord-335975-m6lkrehi 4146 8 induce induce VB cord-335975-m6lkrehi 4146 9 an an DT cord-335975-m6lkrehi 4146 10 endothelial endothelial JJ cord-335975-m6lkrehi 4146 11 vasorelaxation vasorelaxation NN cord-335975-m6lkrehi 4146 12 dysfunction dysfunction NN cord-335975-m6lkrehi 4146 13 mainly mainly RB cord-335975-m6lkrehi 4146 14 mediated mediate VBN cord-335975-m6lkrehi 4146 15 by by IN cord-335975-m6lkrehi 4146 16 nitric nitric NN cord-335975-m6lkrehi 4146 17 oxyde oxyde NN cord-335975-m6lkrehi 4146 18 ( ( -LRB- cord-335975-m6lkrehi 4146 19 NO no DT cord-335975-m6lkrehi 4146 20 Introduction introduction NN cord-335975-m6lkrehi 4146 21 : : : cord-335975-m6lkrehi 4147 1 During during IN cord-335975-m6lkrehi 4147 2 circulatory circulatory JJ cord-335975-m6lkrehi 4147 3 shock shock NN cord-335975-m6lkrehi 4147 4 , , , cord-335975-m6lkrehi 4147 5 the the DT cord-335975-m6lkrehi 4147 6 goal goal NN cord-335975-m6lkrehi 4147 7 of of IN cord-335975-m6lkrehi 4147 8 increasing increase VBG cord-335975-m6lkrehi 4147 9 cardiac cardiac JJ cord-335975-m6lkrehi 4147 10 output output NN cord-335975-m6lkrehi 4147 11 is be VBZ cord-335975-m6lkrehi 4147 12 to to TO cord-335975-m6lkrehi 4147 13 correct correct VB cord-335975-m6lkrehi 4147 14 tissue tissue NN cord-335975-m6lkrehi 4147 15 hypoxia hypoxia NN cord-335975-m6lkrehi 4147 16 , , , cord-335975-m6lkrehi 4147 17 which which WDT cord-335975-m6lkrehi 4147 18 can can MD cord-335975-m6lkrehi 4147 19 be be VB cord-335975-m6lkrehi 4147 20 manifested manifest VBN cord-335975-m6lkrehi 4147 21 by by IN cord-335975-m6lkrehi 4147 22 an an DT cord-335975-m6lkrehi 4147 23 increase increase NN cord-335975-m6lkrehi 4147 24 in in IN cord-335975-m6lkrehi 4147 25 oxygen oxygen NN cord-335975-m6lkrehi 4147 26 consumption consumption NN cord-335975-m6lkrehi 4147 27 ( ( -LRB- cord-335975-m6lkrehi 4147 28 VO2 VO2 NNP cord-335975-m6lkrehi 4147 29 ) ) -RRB- cord-335975-m6lkrehi 4147 30 associated associate VBD cord-335975-m6lkrehi 4147 31 with with IN cord-335975-m6lkrehi 4147 32 an an DT cord-335975-m6lkrehi 4147 33 increase increase NN cord-335975-m6lkrehi 4147 34 in in IN cord-335975-m6lkrehi 4147 35 oxygen oxygen NN cord-335975-m6lkrehi 4147 36 delivery delivery NN cord-335975-m6lkrehi 4147 37 . . . cord-335975-m6lkrehi 4148 1 We -PRON- PRP cord-335975-m6lkrehi 4148 2 hypothesized hypothesize VBD cord-335975-m6lkrehi 4148 3 that that IN cord-335975-m6lkrehi 4148 4 , , , cord-335975-m6lkrehi 4148 5 in in IN cord-335975-m6lkrehi 4148 6 patients patient NNS cord-335975-m6lkrehi 4148 7 in in IN cord-335975-m6lkrehi 4148 8 circulatory circulatory JJ cord-335975-m6lkrehi 4148 9 shock shock NN cord-335975-m6lkrehi 4148 10 , , , cord-335975-m6lkrehi 4148 11 veno veno NN cord-335975-m6lkrehi 4148 12 - - HYPH cord-335975-m6lkrehi 4148 13 arterial arterial JJ cord-335975-m6lkrehi 4148 14 CO2 CO2 NNP cord-335975-m6lkrehi 4148 15 gradients gradient NNS cord-335975-m6lkrehi 4148 16 ( ( -LRB- cord-335975-m6lkrehi 4148 17 Pv Pv NNP cord-335975-m6lkrehi 4148 18 - - HYPH cord-335975-m6lkrehi 4148 19 aCO2 aCO2 NNP cord-335975-m6lkrehi 4148 20 ) ) -RRB- cord-335975-m6lkrehi 4148 21 could could MD cord-335975-m6lkrehi 4148 22 be be VB cord-335975-m6lkrehi 4148 23 a a DT cord-335975-m6lkrehi 4148 24 good good JJ cord-335975-m6lkrehi 4148 25 predictor predictor NN cord-335975-m6lkrehi 4148 26 of of IN cord-335975-m6lkrehi 4148 27 an an DT cord-335975-m6lkrehi 4148 28 increase increase NN cord-335975-m6lkrehi 4148 29 in in IN cord-335975-m6lkrehi 4148 30 VO2 vo2 NN cord-335975-m6lkrehi 4148 31 in in IN cord-335975-m6lkrehi 4148 32 fluid fluid JJ cord-335975-m6lkrehi 4148 33 responders responder NNS cord-335975-m6lkrehi 4148 34 . . . cord-335975-m6lkrehi 4149 1 Patients patient NNS cord-335975-m6lkrehi 4149 2 and and CC cord-335975-m6lkrehi 4149 3 methods method NNS cord-335975-m6lkrehi 4150 1 : : : cord-335975-m6lkrehi 4150 2 We -PRON- PRP cord-335975-m6lkrehi 4150 3 included include VBD cord-335975-m6lkrehi 4150 4 patients patient NNS cord-335975-m6lkrehi 4150 5 with with IN cord-335975-m6lkrehi 4150 6 circulatory circulatory JJ cord-335975-m6lkrehi 4150 7 shock shock NN cord-335975-m6lkrehi 4150 8 who who WP cord-335975-m6lkrehi 4150 9 received receive VBD cord-335975-m6lkrehi 4150 10 a a DT cord-335975-m6lkrehi 4150 11 fluid fluid JJ cord-335975-m6lkrehi 4150 12 challenge challenge NN cord-335975-m6lkrehi 4150 13 . . . cord-335975-m6lkrehi 4151 1 Circulatory circulatory JJ cord-335975-m6lkrehi 4151 2 shock shock NN cord-335975-m6lkrehi 4151 3 was be VBD cord-335975-m6lkrehi 4151 4 defined define VBN cord-335975-m6lkrehi 4151 5 by by IN cord-335975-m6lkrehi 4151 6 the the DT cord-335975-m6lkrehi 4151 7 association association NNP cord-335975-m6lkrehi 4151 8 of of IN cord-335975-m6lkrehi 4151 9 vasopressor vasopressor NNP cord-335975-m6lkrehi 4151 10 requirements requirement NNS cord-335975-m6lkrehi 4151 11 to to TO cord-335975-m6lkrehi 4151 12 maintain maintain VB cord-335975-m6lkrehi 4151 13 mean mean JJ cord-335975-m6lkrehi 4151 14 arterial arterial JJ cord-335975-m6lkrehi 4151 15 pressure pressure NN cord-335975-m6lkrehi 4151 16 ( ( -LRB- cord-335975-m6lkrehi 4151 17 MAP MAP NNP cord-335975-m6lkrehi 4151 18 ) ) -RRB- cord-335975-m6lkrehi 4151 19 and and CC cord-335975-m6lkrehi 4151 20 a a DT cord-335975-m6lkrehi 4151 21 blood blood NN cord-335975-m6lkrehi 4151 22 lactate lactate NN cord-335975-m6lkrehi 4151 23 concentration concentration NN cord-335975-m6lkrehi 4152 1 ≥ ≥ CD cord-335975-m6lkrehi 4152 2 2 2 CD cord-335975-m6lkrehi 4152 3 mmol mmol JJ cord-335975-m6lkrehi 4153 1 L. L. NNP cord-335975-m6lkrehi 4153 2 We -PRON- PRP cord-335975-m6lkrehi 4153 3 measured measure VBD cord-335975-m6lkrehi 4153 4 cardiac cardiac JJ cord-335975-m6lkrehi 4153 5 index index NN cord-335975-m6lkrehi 4153 6 ( ( -LRB- cord-335975-m6lkrehi 4153 7 CI CI NNP cord-335975-m6lkrehi 4153 8 ) ) -RRB- cord-335975-m6lkrehi 4153 9 and and CC cord-335975-m6lkrehi 4153 10 arterial arterial JJ cord-335975-m6lkrehi 4153 11 and and CC cord-335975-m6lkrehi 4153 12 central central JJ cord-335975-m6lkrehi 4153 13 venous venous JJ cord-335975-m6lkrehi 4153 14 blood blood NN cord-335975-m6lkrehi 4153 15 gases gas NNS cord-335975-m6lkrehi 4153 16 and and CC cord-335975-m6lkrehi 4153 17 arterial arterial JJ cord-335975-m6lkrehi 4153 18 lactate lactate NN cord-335975-m6lkrehi 4153 19 before before IN cord-335975-m6lkrehi 4153 20 and and CC cord-335975-m6lkrehi 4153 21 after after IN cord-335975-m6lkrehi 4153 22 a a DT cord-335975-m6lkrehi 4153 23 volume volume NN cord-335975-m6lkrehi 4153 24 expansion expansion NN cord-335975-m6lkrehi 4153 25 ( ( -LRB- cord-335975-m6lkrehi 4153 26 500 500 CD cord-335975-m6lkrehi 4153 27 ml ml NNS cord-335975-m6lkrehi 4153 28 of of IN cord-335975-m6lkrehi 4154 1 Plasmalyte Plasmalyte NNP cord-335975-m6lkrehi 4154 2 ® ® POS cord-335975-m6lkrehi 4154 3 ) ) -RRB- cord-335975-m6lkrehi 4154 4 . . . cord-335975-m6lkrehi 4155 1 Cardiac cardiac JJ cord-335975-m6lkrehi 4155 2 index index NN cord-335975-m6lkrehi 4155 3 ( ( -LRB- cord-335975-m6lkrehi 4155 4 CI CI NNP cord-335975-m6lkrehi 4155 5 ) ) -RRB- cord-335975-m6lkrehi 4155 6 was be VBD cord-335975-m6lkrehi 4155 7 measured measure VBN cord-335975-m6lkrehi 4155 8 using use VBG cord-335975-m6lkrehi 4155 9 a a DT cord-335975-m6lkrehi 4155 10 pulse pulse NN cord-335975-m6lkrehi 4155 11 contour contour NN cord-335975-m6lkrehi 4155 12 analysis analysis NN cord-335975-m6lkrehi 4155 13 method method NN cord-335975-m6lkrehi 4155 14 ( ( -LRB- cord-335975-m6lkrehi 4155 15 PiCCO PiCCO NNP cord-335975-m6lkrehi 4155 16 + + SYM cord-335975-m6lkrehi 4155 17 Pulsion Pulsion NNP cord-335975-m6lkrehi 4155 18 , , , cord-335975-m6lkrehi 4155 19 Munich Munich NNP cord-335975-m6lkrehi 4155 20 , , , cord-335975-m6lkrehi 4155 21 Germany Germany NNP cord-335975-m6lkrehi 4155 22 ) ) -RRB- cord-335975-m6lkrehi 4155 23 . . . cord-335975-m6lkrehi 4156 1 CI CI NNP cord-335975-m6lkrehi 4156 2 responders responder NNS cord-335975-m6lkrehi 4156 3 were be VBD cord-335975-m6lkrehi 4156 4 the the DT cord-335975-m6lkrehi 4156 5 patients patient NNS cord-335975-m6lkrehi 4156 6 in in IN cord-335975-m6lkrehi 4156 7 whom whom WP cord-335975-m6lkrehi 4156 8 CI CI NNP cord-335975-m6lkrehi 4156 9 increased increase VBD cord-335975-m6lkrehi 4156 10 ( ( -LRB- cord-335975-m6lkrehi 4156 11 ΔCI δci NN cord-335975-m6lkrehi 4156 12 ) ) -RRB- cord-335975-m6lkrehi 4156 13 by by IN cord-335975-m6lkrehi 4156 14 > > XX cord-335975-m6lkrehi 4156 15 15 15 CD cord-335975-m6lkrehi 4156 16 % % NN cord-335975-m6lkrehi 4156 17 . . . cord-335975-m6lkrehi 4157 1 In in IN cord-335975-m6lkrehi 4157 2 those those DT cord-335975-m6lkrehi 4157 3 patients patient NNS cord-335975-m6lkrehi 4157 4 , , , cord-335975-m6lkrehi 4157 5 VO2 vo2 NN cord-335975-m6lkrehi 4157 6 responders responder NNS cord-335975-m6lkrehi 4157 7 were be VBD cord-335975-m6lkrehi 4157 8 those those DT cord-335975-m6lkrehi 4157 9 in in IN cord-335975-m6lkrehi 4157 10 whom whom WP cord-335975-m6lkrehi 4157 11 VO2 VO2 NNP cord-335975-m6lkrehi 4157 12 increased increase VBD cord-335975-m6lkrehi 4157 13 ( ( -LRB- cord-335975-m6lkrehi 4157 14 ΔVO2 ΔVO2 NNP cord-335975-m6lkrehi 4157 15 ) ) -RRB- cord-335975-m6lkrehi 4157 16 by by IN cord-335975-m6lkrehi 4157 17 > > XX cord-335975-m6lkrehi 4157 18 15 15 CD cord-335975-m6lkrehi 4157 19 % % NN cord-335975-m6lkrehi 4157 20 . . . cord-335975-m6lkrehi 4158 1 Receiver receiver NN cord-335975-m6lkrehi 4158 2 operating operating NN cord-335975-m6lkrehi 4158 3 characteristic characteristic NN cord-335975-m6lkrehi 4158 4 ( ( -LRB- cord-335975-m6lkrehi 4158 5 ROC ROC NNP cord-335975-m6lkrehi 4158 6 ) ) -RRB- cord-335975-m6lkrehi 4158 7 curves curve NNS cord-335975-m6lkrehi 4158 8 were be VBD cord-335975-m6lkrehi 4158 9 performed perform VBN cord-335975-m6lkrehi 4158 10 . . . cord-335975-m6lkrehi 4159 1 The the DT cord-335975-m6lkrehi 4159 2 data datum NNS cord-335975-m6lkrehi 4159 3 was be VBD cord-335975-m6lkrehi 4159 4 presented present VBN cord-335975-m6lkrehi 4159 5 as as IN cord-335975-m6lkrehi 4159 6 median median JJ cord-335975-m6lkrehi 4159 7 ( ( -LRB- cord-335975-m6lkrehi 4159 8 25th 25th JJ cord-335975-m6lkrehi 4159 9 percentile-75th percentile-75th JJ cord-335975-m6lkrehi 4159 10 percentile percentile NN cord-335975-m6lkrehi 4159 11 ) ) -RRB- cord-335975-m6lkrehi 4159 12 . . . cord-335975-m6lkrehi 4160 1 A a DT cord-335975-m6lkrehi 4160 2 p p NN cord-335975-m6lkrehi 4160 3 < < XX cord-335975-m6lkrehi 4160 4 0.05 0.05 CD cord-335975-m6lkrehi 4160 5 was be VBD cord-335975-m6lkrehi 4160 6 considered consider VBN cord-335975-m6lkrehi 4160 7 as as RB cord-335975-m6lkrehi 4160 8 statistically statistically RB cord-335975-m6lkrehi 4160 9 significant significant JJ cord-335975-m6lkrehi 4160 10 . . . cord-335975-m6lkrehi 4161 1 Introduction introduction NN cord-335975-m6lkrehi 4161 2 : : : cord-335975-m6lkrehi 4162 1 The the DT cord-335975-m6lkrehi 4162 2 autonomic autonomic JJ cord-335975-m6lkrehi 4162 3 nervous nervous JJ cord-335975-m6lkrehi 4162 4 system system NN cord-335975-m6lkrehi 4162 5 ( ( -LRB- cord-335975-m6lkrehi 4162 6 ANS ANS NNP cord-335975-m6lkrehi 4162 7 ) ) -RRB- cord-335975-m6lkrehi 4162 8 is be VBZ cord-335975-m6lkrehi 4162 9 highly highly RB cord-335975-m6lkrehi 4162 10 adaptable adaptable JJ cord-335975-m6lkrehi 4162 11 and and CC cord-335975-m6lkrehi 4162 12 allows allow VBZ cord-335975-m6lkrehi 4162 13 the the DT cord-335975-m6lkrehi 4162 14 organism organism NN cord-335975-m6lkrehi 4162 15 to to TO cord-335975-m6lkrehi 4162 16 maintain maintain VB cord-335975-m6lkrehi 4162 17 its -PRON- PRP$ cord-335975-m6lkrehi 4162 18 balance balance NN cord-335975-m6lkrehi 4162 19 when when WRB cord-335975-m6lkrehi 4162 20 experiencing experience VBG cord-335975-m6lkrehi 4162 21 stress stress NN cord-335975-m6lkrehi 4162 22 . . . cord-335975-m6lkrehi 4163 1 Heart heart NN cord-335975-m6lkrehi 4163 2 rate rate NN cord-335975-m6lkrehi 4163 3 variability variability NN cord-335975-m6lkrehi 4163 4 ( ( -LRB- cord-335975-m6lkrehi 4163 5 HRV HRV NNP cord-335975-m6lkrehi 4163 6 ) ) -RRB- cord-335975-m6lkrehi 4163 7 is be VBZ cord-335975-m6lkrehi 4163 8 a a DT cord-335975-m6lkrehi 4163 9 mean mean NN cord-335975-m6lkrehi 4163 10 to to TO cord-335975-m6lkrehi 4163 11 evaluate evaluate VB cord-335975-m6lkrehi 4163 12 cardiac cardiac JJ cord-335975-m6lkrehi 4163 13 effects effect NNS cord-335975-m6lkrehi 4163 14 of of IN cord-335975-m6lkrehi 4163 15 ANS ANS NNP cord-335975-m6lkrehi 4163 16 activity activity NN cord-335975-m6lkrehi 4163 17 and and CC cord-335975-m6lkrehi 4163 18 a a DT cord-335975-m6lkrehi 4163 19 relation relation NN cord-335975-m6lkrehi 4163 20 between between IN cord-335975-m6lkrehi 4163 21 HRV HRV NNP cord-335975-m6lkrehi 4163 22 and and CC cord-335975-m6lkrehi 4163 23 outcome outcome NN cord-335975-m6lkrehi 4163 24 has have VBZ cord-335975-m6lkrehi 4163 25 been be VBN cord-335975-m6lkrehi 4163 26 proposed propose VBN cord-335975-m6lkrehi 4163 27 in in IN cord-335975-m6lkrehi 4163 28 various various JJ cord-335975-m6lkrehi 4163 29 types type NNS cord-335975-m6lkrehi 4163 30 of of IN cord-335975-m6lkrehi 4163 31 patients patient NNS cord-335975-m6lkrehi 4163 32 . . . cord-335975-m6lkrehi 4164 1 While while IN cord-335975-m6lkrehi 4164 2 electrocardiographic electrocardiographic JJ cord-335975-m6lkrehi 4164 3 HRV HRV NNP cord-335975-m6lkrehi 4164 4 assessment assessment NN cord-335975-m6lkrehi 4164 5 seems seem VBZ cord-335975-m6lkrehi 4164 6 to to TO cord-335975-m6lkrehi 4164 7 be be VB cord-335975-m6lkrehi 4164 8 the the DT cord-335975-m6lkrehi 4164 9 gold gold NN cord-335975-m6lkrehi 4164 10 standard standard NN cord-335975-m6lkrehi 4164 11 , , , cord-335975-m6lkrehi 4164 12 we -PRON- PRP cord-335975-m6lkrehi 4164 13 evaluated evaluate VBD cord-335975-m6lkrehi 4164 14 the the DT cord-335975-m6lkrehi 4164 15 feasibility feasibility NN cord-335975-m6lkrehi 4164 16 of of IN cord-335975-m6lkrehi 4164 17 an an DT cord-335975-m6lkrehi 4164 18 automated automated JJ cord-335975-m6lkrehi 4164 19 HRV HRV NNP cord-335975-m6lkrehi 4164 20 monitoring monitoring NN cord-335975-m6lkrehi 4164 21 based base VBN cord-335975-m6lkrehi 4164 22 on on IN cord-335975-m6lkrehi 4164 23 standard standard JJ cord-335975-m6lkrehi 4164 24 photoplethysmographic photoplethysmographic JJ cord-335975-m6lkrehi 4164 25 monitoring monitoring NN cord-335975-m6lkrehi 4164 26 . . . cord-335975-m6lkrehi 4165 1 This this DT cord-335975-m6lkrehi 4165 2 project project NN cord-335975-m6lkrehi 4165 3 is be VBZ cord-335975-m6lkrehi 4165 4 based base VBN cord-335975-m6lkrehi 4165 5 on on IN cord-335975-m6lkrehi 4165 6 a a DT cord-335975-m6lkrehi 4165 7 prospective prospective JJ cord-335975-m6lkrehi 4165 8 physiological physiological JJ cord-335975-m6lkrehi 4165 9 tracing tracing NN cord-335975-m6lkrehi 4165 10 data data NN cord-335975-m6lkrehi 4165 11 - - HYPH cord-335975-m6lkrehi 4165 12 warehousing warehousing NN cord-335975-m6lkrehi 4165 13 program program NN cord-335975-m6lkrehi 4165 14 ( ( -LRB- cord-335975-m6lkrehi 4165 15 Rea Rea NNP cord-335975-m6lkrehi 4165 16 STOC STOC NNP cord-335975-m6lkrehi 4165 17 , , , cord-335975-m6lkrehi 4166 1 clinicaltrials.gov clinicaltrials.gov NNP cord-335975-m6lkrehi 4166 2 # # NN cord-335975-m6lkrehi 4166 3 NCT02893462 NCT02893462 NNP cord-335975-m6lkrehi 4166 4 ) ) -RRB- cord-335975-m6lkrehi 4167 1 that that DT cord-335975-m6lkrehi 4167 2 aims aim VBZ cord-335975-m6lkrehi 4167 3 to to TO cord-335975-m6lkrehi 4167 4 record record VB cord-335975-m6lkrehi 4167 5 more more JJR cord-335975-m6lkrehi 4167 6 than than IN cord-335975-m6lkrehi 4167 7 1500 1500 CD cord-335975-m6lkrehi 4167 8 ICU ICU NNP cord-335975-m6lkrehi 4167 9 patients patient NNS cord-335975-m6lkrehi 4167 10 over over IN cord-335975-m6lkrehi 4167 11 a a DT cord-335975-m6lkrehi 4167 12 3-years 3-years CD cord-335975-m6lkrehi 4167 13 period period NN cord-335975-m6lkrehi 4167 14 . . . cord-335975-m6lkrehi 4168 1 Introduction introduction NN cord-335975-m6lkrehi 4168 2 : : : cord-335975-m6lkrehi 4169 1 Diabetic diabetic JJ cord-335975-m6lkrehi 4169 2 ketoacidosis ketoacidosis NN cord-335975-m6lkrehi 4169 3 is be VBZ cord-335975-m6lkrehi 4169 4 an an DT cord-335975-m6lkrehi 4169 5 acute acute JJ cord-335975-m6lkrehi 4169 6 complication complication NN cord-335975-m6lkrehi 4169 7 of of IN cord-335975-m6lkrehi 4169 8 diabetes diabetes NN cord-335975-m6lkrehi 4169 9 , , , cord-335975-m6lkrehi 4169 10 defined define VBN cord-335975-m6lkrehi 4169 11 as as IN cord-335975-m6lkrehi 4169 12 metabolic metabolic JJ cord-335975-m6lkrehi 4169 13 acidosis acidosis NN cord-335975-m6lkrehi 4169 14 with with IN cord-335975-m6lkrehi 4169 15 a a DT cord-335975-m6lkrehi 4169 16 high high JJ cord-335975-m6lkrehi 4169 17 anionic anionic JJ cord-335975-m6lkrehi 4169 18 gap gap NN cord-335975-m6lkrehi 4169 19 , , , cord-335975-m6lkrehi 4169 20 associating associate VBG cord-335975-m6lkrehi 4169 21 hyperglycemia hyperglycemia NN cord-335975-m6lkrehi 4169 22 > > XX cord-335975-m6lkrehi 4169 23 16 16 CD cord-335975-m6lkrehi 4169 24 mmol mmol JJ cord-335975-m6lkrehi 4169 25 l l NN cord-335975-m6lkrehi 4169 26 ( ( -LRB- cord-335975-m6lkrehi 4169 27 3 3 CD cord-335975-m6lkrehi 4169 28 g g NN cord-335975-m6lkrehi 4169 29 l l NN cord-335975-m6lkrehi 4169 30 ) ) -RRB- cord-335975-m6lkrehi 4169 31 , , , cord-335975-m6lkrehi 4169 32 positive positive JJ cord-335975-m6lkrehi 4169 33 ketonuria ketonuria NNS cord-335975-m6lkrehi 4169 34 , , , cord-335975-m6lkrehi 4169 35 or or CC cord-335975-m6lkrehi 4169 36 superior superior JJ cord-335975-m6lkrehi 4169 37 or or CC cord-335975-m6lkrehi 4169 38 equal equal JJ cord-335975-m6lkrehi 4169 39 ketonuria ketonuria NNS cord-335975-m6lkrehi 4169 40 to to IN cord-335975-m6lkrehi 4170 1 + + CC cord-335975-m6lkrehi 4170 2 + + CC cord-335975-m6lkrehi 4170 3 , , , cord-335975-m6lkrehi 4170 4 it -PRON- PRP cord-335975-m6lkrehi 4170 5 is be VBZ cord-335975-m6lkrehi 4170 6 a a DT cord-335975-m6lkrehi 4170 7 medical medical JJ cord-335975-m6lkrehi 4170 8 emergency emergency NN cord-335975-m6lkrehi 4170 9 which which WDT cord-335975-m6lkrehi 4170 10 can can MD cord-335975-m6lkrehi 4170 11 occur occur VB cord-335975-m6lkrehi 4170 12 in in IN cord-335975-m6lkrehi 4170 13 a a DT cord-335975-m6lkrehi 4170 14 known know VBN cord-335975-m6lkrehi 4170 15 diabetic diabetic JJ cord-335975-m6lkrehi 4170 16 patient patient NN cord-335975-m6lkrehi 4170 17 , , , cord-335975-m6lkrehi 4170 18 or or CC cord-335975-m6lkrehi 4170 19 not not RB cord-335975-m6lkrehi 4170 20 . . . cord-335975-m6lkrehi 4171 1 OBJECTIVE- OBJECTIVE- NNP cord-335975-m6lkrehi 4172 1 To to TO cord-335975-m6lkrehi 4172 2 describe describe VB cord-335975-m6lkrehi 4172 3 the the DT cord-335975-m6lkrehi 4172 4 clinical clinical JJ cord-335975-m6lkrehi 4172 5 therapeutic therapeutic JJ cord-335975-m6lkrehi 4172 6 and and CC cord-335975-m6lkrehi 4172 7 prognostic prognostic JJ cord-335975-m6lkrehi 4172 8 aspects aspect NNS cord-335975-m6lkrehi 4172 9 of of IN cord-335975-m6lkrehi 4172 10 diabetic diabetic JJ cord-335975-m6lkrehi 4172 11 ketoacidosis ketoacidosis NN cord-335975-m6lkrehi 4172 12 in in IN cord-335975-m6lkrehi 4172 13 the the DT cord-335975-m6lkrehi 4172 14 intensive intensive JJ cord-335975-m6lkrehi 4172 15 Pediatric Pediatric NNP cord-335975-m6lkrehi 4172 16 care care NN cord-335975-m6lkrehi 4172 17 unit unit NN cord-335975-m6lkrehi 4172 18 at at IN cord-335975-m6lkrehi 4172 19 the the DT cord-335975-m6lkrehi 4172 20 EHS EHS NNP cord-335975-m6lkrehi 4172 21 Canastel Canastel NNP cord-335975-m6lkrehi 4172 22 Oran Oran NNP cord-335975-m6lkrehi 4172 23 , , , cord-335975-m6lkrehi 4172 24 Algeria Algeria NNP cord-335975-m6lkrehi 4172 25 . . . cord-335975-m6lkrehi 4173 1 Patients patient NNS cord-335975-m6lkrehi 4173 2 and and CC cord-335975-m6lkrehi 4173 3 methods method NNS cord-335975-m6lkrehi 4173 4 : : : cord-335975-m6lkrehi 4173 5 Retrospective retrospective JJ cord-335975-m6lkrehi 4173 6 study study NN cord-335975-m6lkrehi 4173 7 carried carry VBD cord-335975-m6lkrehi 4173 8 out out RP cord-335975-m6lkrehi 4173 9 over over IN cord-335975-m6lkrehi 4173 10 a a DT cord-335975-m6lkrehi 4173 11 period period NN cord-335975-m6lkrehi 4173 12 of of IN cord-335975-m6lkrehi 4173 13 2 2 CD cord-335975-m6lkrehi 4173 14 years year NNS cord-335975-m6lkrehi 4173 15 . . . cord-335975-m6lkrehi 4174 1 From from IN cord-335975-m6lkrehi 4174 2 January January NNP cord-335975-m6lkrehi 4174 3 1 1 CD cord-335975-m6lkrehi 4174 4 , , , cord-335975-m6lkrehi 4174 5 2015 2015 CD cord-335975-m6lkrehi 4174 6 to to IN cord-335975-m6lkrehi 4174 7 January January NNP cord-335975-m6lkrehi 4174 8 1 1 CD cord-335975-m6lkrehi 4174 9 , , , cord-335975-m6lkrehi 4174 10 2017 2017 CD cord-335975-m6lkrehi 4174 11 , , , cord-335975-m6lkrehi 4174 12 in in IN cord-335975-m6lkrehi 4174 13 the the DT cord-335975-m6lkrehi 4174 14 intensive intensive JJ cord-335975-m6lkrehi 4174 15 pediatric pediatric JJ cord-335975-m6lkrehi 4174 16 care care NN cord-335975-m6lkrehi 4174 17 service service NN cord-335975-m6lkrehi 4174 18 . . . cord-335975-m6lkrehi 4175 1 The the DT cord-335975-m6lkrehi 4175 2 data datum NNS cord-335975-m6lkrehi 4175 3 was be VBD cord-335975-m6lkrehi 4175 4 entered enter VBN cord-335975-m6lkrehi 4175 5 and and CC cord-335975-m6lkrehi 4175 6 analyzed analyze VBN cord-335975-m6lkrehi 4175 7 using use VBG cord-335975-m6lkrehi 4175 8 Excel Excel NNP cord-335975-m6lkrehi 4175 9 2007 2007 CD cord-335975-m6lkrehi 4175 10 . . . cord-335975-m6lkrehi 4176 1 Results result NNS cord-335975-m6lkrehi 4176 2 : : : cord-335975-m6lkrehi 4176 3 16 16 CD cord-335975-m6lkrehi 4176 4 cases case NNS cord-335975-m6lkrehi 4176 5 were be VBD cord-335975-m6lkrehi 4176 6 retained retain VBN cord-335975-m6lkrehi 4176 7 on on IN cord-335975-m6lkrehi 4176 8 450 450 CD cord-335975-m6lkrehi 4176 9 hospitalizations hospitalization NNS cord-335975-m6lkrehi 4176 10 per per IN cord-335975-m6lkrehi 4176 11 year year NN cord-335975-m6lkrehi 4176 12 , , , cord-335975-m6lkrehi 4176 13 95 95 CD cord-335975-m6lkrehi 4176 14 % % NN cord-335975-m6lkrehi 4176 15 of of IN cord-335975-m6lkrehi 4176 16 cases case NNS cord-335975-m6lkrehi 4176 17 had have VBD cord-335975-m6lkrehi 4176 18 no no DT cord-335975-m6lkrehi 4176 19 history history NN cord-335975-m6lkrehi 4176 20 with with IN cord-335975-m6lkrehi 4176 21 diabetes diabetes NN cord-335975-m6lkrehi 4176 22 , , , cord-335975-m6lkrehi 4176 23 5 5 CD cord-335975-m6lkrehi 4176 24 % % NN cord-335975-m6lkrehi 4176 25 occurred occur VBD cord-335975-m6lkrehi 4176 26 in in IN cord-335975-m6lkrehi 4176 27 known know VBN cord-335975-m6lkrehi 4176 28 diabetics diabetic NNS cord-335975-m6lkrehi 4176 29 with with IN cord-335975-m6lkrehi 4176 30 insulin insulin NN cord-335975-m6lkrehi 4176 31 , , , cord-335975-m6lkrehi 4176 32 but but CC cord-335975-m6lkrehi 4176 33 are be VBP cord-335975-m6lkrehi 4176 34 not not RB cord-335975-m6lkrehi 4176 35 followed follow VBN cord-335975-m6lkrehi 4176 36 medically medically RB cord-335975-m6lkrehi 4176 37 . . . cord-335975-m6lkrehi 4177 1 Our -PRON- PRP$ cord-335975-m6lkrehi 4177 2 patients patient NNS cord-335975-m6lkrehi 4177 3 were be VBD cord-335975-m6lkrehi 4177 4 aged age VBN cord-335975-m6lkrehi 4177 5 from from IN cord-335975-m6lkrehi 4177 6 10 10 CD cord-335975-m6lkrehi 4177 7 months month NNS cord-335975-m6lkrehi 4177 8 to to IN cord-335975-m6lkrehi 4177 9 15 15 CD cord-335975-m6lkrehi 4177 10 years year NNS cord-335975-m6lkrehi 4177 11 , , , cord-335975-m6lkrehi 4177 12 but but CC cord-335975-m6lkrehi 4177 13 the the DT cord-335975-m6lkrehi 4177 14 average average JJ cord-335975-m6lkrehi 4177 15 age age NN cord-335975-m6lkrehi 4177 16 of of IN cord-335975-m6lkrehi 4177 17 these these DT cord-335975-m6lkrehi 4177 18 patients patient NNS cord-335975-m6lkrehi 4177 19 was be VBD cord-335975-m6lkrehi 4177 20 6 6 CD cord-335975-m6lkrehi 4177 21 years year NNS cord-335975-m6lkrehi 4177 22 and and CC cord-335975-m6lkrehi 4177 23 5 5 CD cord-335975-m6lkrehi 4177 24 months month NNS cord-335975-m6lkrehi 4177 25 , , , cord-335975-m6lkrehi 4177 26 with with IN cord-335975-m6lkrehi 4177 27 a a DT cord-335975-m6lkrehi 4177 28 slight slight JJ cord-335975-m6lkrehi 4177 29 female female JJ cord-335975-m6lkrehi 4177 30 predominance predominance NN cord-335975-m6lkrehi 4177 31 , , , cord-335975-m6lkrehi 4177 32 coma coma NN cord-335975-m6lkrehi 4177 33 was be VBD cord-335975-m6lkrehi 4177 34 preceeded preceede VBN cord-335975-m6lkrehi 4177 35 by by IN cord-335975-m6lkrehi 4177 36 75 75 CD cord-335975-m6lkrehi 4177 37 % % NN cord-335975-m6lkrehi 4177 38 of of IN cord-335975-m6lkrehi 4177 39 cases case NNS cord-335975-m6lkrehi 4177 40 polydipsy polydipsy NNP cord-335975-m6lkrehi 4177 41 polyuria polyuria NNP cord-335975-m6lkrehi 4177 42 syndrome syndrome NN cord-335975-m6lkrehi 4177 43 and and CC cord-335975-m6lkrehi 4177 44 12 12 CD cord-335975-m6lkrehi 4177 45 % % NN cord-335975-m6lkrehi 4177 46 weight weight NN cord-335975-m6lkrehi 4177 47 loss loss NN cord-335975-m6lkrehi 4177 48 , , , cord-335975-m6lkrehi 4177 49 triggered trigger VBN cord-335975-m6lkrehi 4177 50 by by IN cord-335975-m6lkrehi 4177 51 an an DT cord-335975-m6lkrehi 4177 52 infectious infectious JJ cord-335975-m6lkrehi 4177 53 syndrome syndrome NN cord-335975-m6lkrehi 4177 54 including include VBG cord-335975-m6lkrehi 4177 55 31 31 CD cord-335975-m6lkrehi 4177 56 % % NN cord-335975-m6lkrehi 4177 57 of of IN cord-335975-m6lkrehi 4177 58 ENT ENT NNP cord-335975-m6lkrehi 4177 59 cases case NNS cord-335975-m6lkrehi 4177 60 , , , cord-335975-m6lkrehi 4177 61 12 12 CD cord-335975-m6lkrehi 4177 62 % % NN cord-335975-m6lkrehi 4177 63 of of IN cord-335975-m6lkrehi 4177 64 respiratory respiratory JJ cord-335975-m6lkrehi 4177 65 infections infection NNS cord-335975-m6lkrehi 4177 66 and and CC cord-335975-m6lkrehi 4177 67 12 12 CD cord-335975-m6lkrehi 4177 68 % % NN cord-335975-m6lkrehi 4177 69 of of IN cord-335975-m6lkrehi 4177 70 cases case NNS cord-335975-m6lkrehi 4177 71 with with IN cord-335975-m6lkrehi 4177 72 digestive digestive JJ cord-335975-m6lkrehi 4177 73 infections infection NNS cord-335975-m6lkrehi 4177 74 characterized characterize VBN cord-335975-m6lkrehi 4177 75 by by IN cord-335975-m6lkrehi 4177 76 fever fever NN cord-335975-m6lkrehi 4177 77 , , , cord-335975-m6lkrehi 4177 78 abdominal abdominal JJ cord-335975-m6lkrehi 4177 79 pain pain NN cord-335975-m6lkrehi 4177 80 , , , cord-335975-m6lkrehi 4177 81 vomiting vomit VBG cord-335975-m6lkrehi 4177 82 . . . cord-335975-m6lkrehi 4178 1 The the DT cord-335975-m6lkrehi 4178 2 delay delay NN cord-335975-m6lkrehi 4178 3 between between IN cord-335975-m6lkrehi 4178 4 diagnosis diagnosis NN cord-335975-m6lkrehi 4178 5 and and CC cord-335975-m6lkrehi 4178 6 admission admission NN cord-335975-m6lkrehi 4178 7 to to IN cord-335975-m6lkrehi 4178 8 ICE ice NN cord-335975-m6lkrehi 4178 9 was be VBD cord-335975-m6lkrehi 4178 10 24 24 CD cord-335975-m6lkrehi 4178 11 - - SYM cord-335975-m6lkrehi 4178 12 7 7 CD cord-335975-m6lkrehi 4178 13 days day NNS cord-335975-m6lkrehi 4178 14 . . . cord-335975-m6lkrehi 4179 1 At at IN cord-335975-m6lkrehi 4179 2 admission admission NN cord-335975-m6lkrehi 4179 3 80 80 CD cord-335975-m6lkrehi 4179 4 % % NN cord-335975-m6lkrehi 4179 5 of of IN cord-335975-m6lkrehi 4179 6 patients patient NNS cord-335975-m6lkrehi 4179 7 were be VBD cord-335975-m6lkrehi 4179 8 scored score VBN cord-335975-m6lkrehi 4179 9 at at IN cord-335975-m6lkrehi 4179 10 11 11 CD cord-335975-m6lkrehi 4179 11 15 15 CD cord-335975-m6lkrehi 4179 12 on on IN cord-335975-m6lkrehi 4179 13 the the DT cord-335975-m6lkrehi 4179 14 Glasgow Glasgow NNP cord-335975-m6lkrehi 4179 15 scale scale NN cord-335975-m6lkrehi 4179 16 , , , cord-335975-m6lkrehi 4179 17 with with IN cord-335975-m6lkrehi 4179 18 presence presence NN cord-335975-m6lkrehi 4179 19 of of IN cord-335975-m6lkrehi 4179 20 the the DT cord-335975-m6lkrehi 4179 21 cough cough NN cord-335975-m6lkrehi 4179 22 reflex reflex NN cord-335975-m6lkrehi 4179 23 , , , cord-335975-m6lkrehi 4179 24 and and CC cord-335975-m6lkrehi 4179 25 20 20 CD cord-335975-m6lkrehi 4179 26 % % NN cord-335975-m6lkrehi 4179 27 were be VBD cord-335975-m6lkrehi 4179 28 scored score VBN cord-335975-m6lkrehi 4179 29 at at IN cord-335975-m6lkrehi 4179 30 < < NNP cord-335975-m6lkrehi 4179 31 7 7 CD cord-335975-m6lkrehi 4179 32 15 15 CD cord-335975-m6lkrehi 4179 33 requiring require VBG cord-335975-m6lkrehi 4179 34 tracheal tracheal JJ cord-335975-m6lkrehi 4179 35 intubation intubation NN cord-335975-m6lkrehi 4179 36 and and CC cord-335975-m6lkrehi 4179 37 mechanical mechanical JJ cord-335975-m6lkrehi 4179 38 ventilation ventilation NN cord-335975-m6lkrehi 4179 39 of of IN cord-335975-m6lkrehi 4179 40 48 48 CD cord-335975-m6lkrehi 4179 41 h h NN cord-335975-m6lkrehi 4179 42 with with IN cord-335975-m6lkrehi 4179 43 signs sign NNS cord-335975-m6lkrehi 4179 44 of of IN cord-335975-m6lkrehi 4179 45 dehydration dehydration NN cord-335975-m6lkrehi 4179 46 and and CC cord-335975-m6lkrehi 4179 47 ionic ionic JJ cord-335975-m6lkrehi 4179 48 disorders disorder NNS cord-335975-m6lkrehi 4179 49 , , , cord-335975-m6lkrehi 4179 50 namely namely RB cord-335975-m6lkrehi 4179 51 hypokalemia hypokalemia NN cord-335975-m6lkrehi 4179 52 and and CC cord-335975-m6lkrehi 4179 53 hypernatremia hypernatremia NN cord-335975-m6lkrehi 4179 54 , , , cord-335975-m6lkrehi 4179 55 blood blood NN cord-335975-m6lkrehi 4179 56 glucose glucose NN cord-335975-m6lkrehi 4179 57 at at IN cord-335975-m6lkrehi 4179 58 admission admission NN cord-335975-m6lkrehi 4179 59 varies vary VBZ cord-335975-m6lkrehi 4179 60 between between IN cord-335975-m6lkrehi 4179 61 3.5 3.5 CD cord-335975-m6lkrehi 4179 62 and and CC cord-335975-m6lkrehi 4179 63 5 5 CD cord-335975-m6lkrehi 4179 64 g g NN cord-335975-m6lkrehi 4179 65 l l NN cord-335975-m6lkrehi 4179 66 with with IN cord-335975-m6lkrehi 4179 67 glycosuria glycosuria NNP cord-335975-m6lkrehi 4179 68 at at IN cord-335975-m6lkrehi 4180 1 + + CC cord-335975-m6lkrehi 4181 1 + + CC cord-335975-m6lkrehi 4181 2 + + CC cord-335975-m6lkrehi 4182 1 and and CC cord-335975-m6lkrehi 4182 2 ketonesuria ketonesuria NNP cord-335975-m6lkrehi 4182 3 between between IN cord-335975-m6lkrehi 4182 4 + + SYM cord-335975-m6lkrehi 4182 5 + + CC cord-335975-m6lkrehi 4182 6 and and CC cord-335975-m6lkrehi 4182 7 + + . cord-335975-m6lkrehi 4183 1 + + CC cord-335975-m6lkrehi 4184 1 + + CC cord-335975-m6lkrehi 4184 2 + + CC cord-335975-m6lkrehi 4185 1 in in IN cord-335975-m6lkrehi 4185 2 only only RB cord-335975-m6lkrehi 4185 3 18 18 CD cord-335975-m6lkrehi 4185 4 % % NN cord-335975-m6lkrehi 4185 5 of of IN cord-335975-m6lkrehi 4185 6 the the DT cord-335975-m6lkrehi 4185 7 patients patient NNS cord-335975-m6lkrehi 4185 8 had have VBD cord-335975-m6lkrehi 4185 9 metabolic metabolic JJ cord-335975-m6lkrehi 4185 10 acidosis acidosis NN cord-335975-m6lkrehi 4185 11 , , , cord-335975-m6lkrehi 4185 12 a a DT cord-335975-m6lkrehi 4185 13 cerebral cerebral JJ cord-335975-m6lkrehi 4185 14 computed compute VBN cord-335975-m6lkrehi 4185 15 tomography tomography NN cord-335975-m6lkrehi 4185 16 ( ( -LRB- cord-335975-m6lkrehi 4185 17 CT CT NNP cord-335975-m6lkrehi 4185 18 ) ) -RRB- cord-335975-m6lkrehi 4185 19 performed perform VBD cord-335975-m6lkrehi 4185 20 in in IN cord-335975-m6lkrehi 4185 21 13 13 CD cord-335975-m6lkrehi 4185 22 % % NN cord-335975-m6lkrehi 4185 23 of of IN cord-335975-m6lkrehi 4185 24 cases case NNS cord-335975-m6lkrehi 4186 1 found find VBD cord-335975-m6lkrehi 4186 2 a a DT cord-335975-m6lkrehi 4186 3 slight slight JJ cord-335975-m6lkrehi 4186 4 cerebral cerebral JJ cord-335975-m6lkrehi 4186 5 edema edema NN cord-335975-m6lkrehi 4186 6 . . . cord-335975-m6lkrehi 4187 1 Therapeutic therapeutic JJ cord-335975-m6lkrehi 4187 2 management management NN cord-335975-m6lkrehi 4187 3 was be VBD cord-335975-m6lkrehi 4187 4 the the DT cord-335975-m6lkrehi 4187 5 rehydration rehydration NN cord-335975-m6lkrehi 4187 6 , , , cord-335975-m6lkrehi 4187 7 correction correction NN cord-335975-m6lkrehi 4187 8 of of IN cord-335975-m6lkrehi 4187 9 metabolic metabolic JJ cord-335975-m6lkrehi 4187 10 disorders disorder NNS cord-335975-m6lkrehi 4187 11 and and CC cord-335975-m6lkrehi 4187 12 introduction introduction NN cord-335975-m6lkrehi 4187 13 of of IN cord-335975-m6lkrehi 4187 14 insulin insulin NN cord-335975-m6lkrehi 4187 15 into into IN cord-335975-m6lkrehi 4187 16 SAP SAP NNP cord-335975-m6lkrehi 4187 17 , , , cord-335975-m6lkrehi 4187 18 with with IN cord-335975-m6lkrehi 4187 19 monitoring monitoring NN cord-335975-m6lkrehi 4187 20 and and CC cord-335975-m6lkrehi 4187 21 subcutaneous subcutaneous JJ cord-335975-m6lkrehi 4187 22 relaying relaying NN cord-335975-m6lkrehi 4187 23 due due IN cord-335975-m6lkrehi 4187 24 to to IN cord-335975-m6lkrehi 4187 25 ketonuria ketonuria FW cord-335975-m6lkrehi 4187 26 negativity negativity NN cord-335975-m6lkrehi 4187 27 . . . cord-335975-m6lkrehi 4188 1 The the DT cord-335975-m6lkrehi 4188 2 outcome outcome NN cord-335975-m6lkrehi 4188 3 was be VBD cord-335975-m6lkrehi 4188 4 favorable favorable JJ cord-335975-m6lkrehi 4188 5 for for IN cord-335975-m6lkrehi 4188 6 all all DT cord-335975-m6lkrehi 4188 7 patients patient NNS cord-335975-m6lkrehi 4188 8 . . . cord-335975-m6lkrehi 4189 1 Conclusion conclusion NN cord-335975-m6lkrehi 4189 2 : : : cord-335975-m6lkrehi 4189 3 Diabetic diabetic JJ cord-335975-m6lkrehi 4189 4 ketoacidosis ketoacidosis NN cord-335975-m6lkrehi 4189 5 is be VBZ cord-335975-m6lkrehi 4189 6 a a DT cord-335975-m6lkrehi 4189 7 major major JJ cord-335975-m6lkrehi 4189 8 complication complication NN cord-335975-m6lkrehi 4189 9 of of IN cord-335975-m6lkrehi 4189 10 diabetes diabetes NN cord-335975-m6lkrehi 4189 11 which which WDT cord-335975-m6lkrehi 4189 12 can can MD cord-335975-m6lkrehi 4189 13 be be VB cord-335975-m6lkrehi 4189 14 avoided avoid VBN cord-335975-m6lkrehi 4189 15 by by IN cord-335975-m6lkrehi 4189 16 a a DT cord-335975-m6lkrehi 4189 17 good good JJ cord-335975-m6lkrehi 4189 18 prevention prevention NN cord-335975-m6lkrehi 4189 19 campaign campaign NN cord-335975-m6lkrehi 4189 20 and and CC cord-335975-m6lkrehi 4189 21 systematic systematic JJ cord-335975-m6lkrehi 4189 22 screening screening NN cord-335975-m6lkrehi 4189 23 of of IN cord-335975-m6lkrehi 4189 24 any any DT cord-335975-m6lkrehi 4189 25 child child NN cord-335975-m6lkrehi 4189 26 suspected suspect VBN cord-335975-m6lkrehi 4189 27 of of IN cord-335975-m6lkrehi 4189 28 diabetes diabetes NN cord-335975-m6lkrehi 4189 29 , , , cord-335975-m6lkrehi 4189 30 recognition recognition NN cord-335975-m6lkrehi 4189 31 of of IN cord-335975-m6lkrehi 4189 32 risk risk NN cord-335975-m6lkrehi 4189 33 situations situation NNS cord-335975-m6lkrehi 4189 34 such such JJ cord-335975-m6lkrehi 4189 35 as as IN cord-335975-m6lkrehi 4189 36 infections infection NNS cord-335975-m6lkrehi 4189 37 and and CC cord-335975-m6lkrehi 4189 38 clinical clinical JJ cord-335975-m6lkrehi 4189 39 manifestations manifestation NNS cord-335975-m6lkrehi 4189 40 in in IN cord-335975-m6lkrehi 4189 41 order order NN cord-335975-m6lkrehi 4189 42 not not RB cord-335975-m6lkrehi 4189 43 to to TO cord-335975-m6lkrehi 4189 44 delay delay VB cord-335975-m6lkrehi 4189 45 the the DT cord-335975-m6lkrehi 4189 46 management management NN cord-335975-m6lkrehi 4189 47 . . . cord-335975-m6lkrehi 4190 1 Introduction introduction NN cord-335975-m6lkrehi 4190 2 : : : cord-335975-m6lkrehi 4191 1 Scorpion scorpion NN cord-335975-m6lkrehi 4191 2 sting sting NN cord-335975-m6lkrehi 4191 3 is be VBZ cord-335975-m6lkrehi 4191 4 a a DT cord-335975-m6lkrehi 4191 5 public public JJ cord-335975-m6lkrehi 4191 6 health health NN cord-335975-m6lkrehi 4191 7 problem problem NN cord-335975-m6lkrehi 4191 8 world world NN cord-335975-m6lkrehi 4191 9 wide wide JJ cord-335975-m6lkrehi 4191 10 with with IN cord-335975-m6lkrehi 4191 11 a a DT cord-335975-m6lkrehi 4191 12 global global JJ cord-335975-m6lkrehi 4191 13 distribution distribution NN cord-335975-m6lkrehi 4191 14 of of IN cord-335975-m6lkrehi 4191 15 1500 1500 CD cord-335975-m6lkrehi 4191 16 species specie NNS cord-335975-m6lkrehi 4191 17 . . . cord-335975-m6lkrehi 4192 1 In in IN cord-335975-m6lkrehi 4192 2 Algeria Algeria NNP cord-335975-m6lkrehi 4192 3 , , , cord-335975-m6lkrehi 4192 4 scorpionic scorpionic JJ cord-335975-m6lkrehi 4192 5 envenomation envenomation NN cord-335975-m6lkrehi 4192 6 occupies occupy VBZ cord-335975-m6lkrehi 4192 7 a a DT cord-335975-m6lkrehi 4192 8 prominent prominent JJ cord-335975-m6lkrehi 4192 9 place place NN cord-335975-m6lkrehi 4192 10 in in IN cord-335975-m6lkrehi 4192 11 declarations declaration NNS cord-335975-m6lkrehi 4192 12 . . . cord-335975-m6lkrehi 4193 1 In in IN cord-335975-m6lkrehi 4193 2 2016 2016 CD cord-335975-m6lkrehi 4193 3 , , , cord-335975-m6lkrehi 4193 4 43000 43000 CD cord-335975-m6lkrehi 4193 5 cases case NNS cord-335975-m6lkrehi 4193 6 were be VBD cord-335975-m6lkrehi 4193 7 reported report VBN cord-335975-m6lkrehi 4193 8 . . . cord-335975-m6lkrehi 4194 1 The the DT cord-335975-m6lkrehi 4194 2 objective objective NN cord-335975-m6lkrehi 4194 3 of of IN cord-335975-m6lkrehi 4194 4 our -PRON- PRP$ cord-335975-m6lkrehi 4194 5 study study NN cord-335975-m6lkrehi 4194 6 is be VBZ cord-335975-m6lkrehi 4194 7 to to TO cord-335975-m6lkrehi 4194 8 describe describe VB cord-335975-m6lkrehi 4194 9 the the DT cord-335975-m6lkrehi 4194 10 epidemiological epidemiological JJ cord-335975-m6lkrehi 4194 11 , , , cord-335975-m6lkrehi 4194 12 diagnostic diagnostic JJ cord-335975-m6lkrehi 4194 13 , , , cord-335975-m6lkrehi 4194 14 therapeutic therapeutic JJ cord-335975-m6lkrehi 4194 15 and and CC cord-335975-m6lkrehi 4194 16 evolutionary evolutionary JJ cord-335975-m6lkrehi 4194 17 characteristics characteristic NNS cord-335975-m6lkrehi 4194 18 of of IN cord-335975-m6lkrehi 4194 19 the the DT cord-335975-m6lkrehi 4194 20 scorpion scorpion NN cord-335975-m6lkrehi 4194 21 sting sting NN cord-335975-m6lkrehi 4194 22 in in IN cord-335975-m6lkrehi 4194 23 children child NNS cord-335975-m6lkrehi 4194 24 . . . cord-335975-m6lkrehi 4195 1 Retrospective retrospective JJ cord-335975-m6lkrehi 4195 2 study study NN cord-335975-m6lkrehi 4195 3 of of IN cord-335975-m6lkrehi 4195 4 07 07 CD cord-335975-m6lkrehi 4195 5 cases case NNS cord-335975-m6lkrehi 4195 6 of of IN cord-335975-m6lkrehi 4195 7 scorpionic scorpionic JJ cord-335975-m6lkrehi 4195 8 envenomation envenomation NN cord-335975-m6lkrehi 4195 9 hospitalized hospitalize VBN cord-335975-m6lkrehi 4195 10 in in IN cord-335975-m6lkrehi 4195 11 the the DT cord-335975-m6lkrehi 4195 12 pediatric pediatric JJ cord-335975-m6lkrehi 4195 13 resuscitation resuscitation NN cord-335975-m6lkrehi 4195 14 department department NN cord-335975-m6lkrehi 4195 15 of of IN cord-335975-m6lkrehi 4195 16 the the DT cord-335975-m6lkrehi 4195 17 EHS EHS NNP cord-335975-m6lkrehi 4195 18 Canastel Canastel NNP cord-335975-m6lkrehi 4195 19 ORAN ORAN NNP cord-335975-m6lkrehi 4195 20 conducted conduct VBD cord-335975-m6lkrehi 4195 21 during during IN cord-335975-m6lkrehi 4195 22 the the DT cord-335975-m6lkrehi 4195 23 year year NN cord-335975-m6lkrehi 4195 24 2016The 2016the CD cord-335975-m6lkrehi 4195 25 inclusion inclusion NN cord-335975-m6lkrehi 4195 26 criteria criterion NNS cord-335975-m6lkrehi 4195 27 were be VBD cord-335975-m6lkrehi 4195 28 the the DT cord-335975-m6lkrehi 4195 29 presence presence NN cord-335975-m6lkrehi 4195 30 of of IN cord-335975-m6lkrehi 4195 31 traces trace NNS cord-335975-m6lkrehi 4195 32 with with IN cord-335975-m6lkrehi 4195 33 at at RB cord-335975-m6lkrehi 4195 34 least least RBS cord-335975-m6lkrehi 4195 35 one one CD cord-335975-m6lkrehi 4195 36 locoregional locoregional JJ cord-335975-m6lkrehi 4195 37 or or CC cord-335975-m6lkrehi 4195 38 general general JJ cord-335975-m6lkrehi 4195 39 clinical clinical JJ cord-335975-m6lkrehi 4195 40 signs sign NNS cord-335975-m6lkrehi 4195 41 . . . cord-335975-m6lkrehi 4196 1 The the DT cord-335975-m6lkrehi 4196 2 parameters parameter NNS cord-335975-m6lkrehi 4196 3 studied study VBD cord-335975-m6lkrehi 4196 4 - - HYPH cord-335975-m6lkrehi 4196 5 age age NN cord-335975-m6lkrehi 4196 6 , , , cord-335975-m6lkrehi 4196 7 sex sex NN cord-335975-m6lkrehi 4196 8 , , , cord-335975-m6lkrehi 4196 9 city city NN cord-335975-m6lkrehi 4196 10 of of IN cord-335975-m6lkrehi 4196 11 origin origin NN cord-335975-m6lkrehi 4196 12 , , , cord-335975-m6lkrehi 4196 13 time time NN cord-335975-m6lkrehi 4196 14 of of IN cord-335975-m6lkrehi 4196 15 bite bite NN cord-335975-m6lkrehi 4196 16 , , , cord-335975-m6lkrehi 4196 17 time time NN cord-335975-m6lkrehi 4196 18 of of IN cord-335975-m6lkrehi 4196 19 management management NN cord-335975-m6lkrehi 4196 20 , , , cord-335975-m6lkrehi 4196 21 initial initial JJ cord-335975-m6lkrehi 4196 22 first first JJ cord-335975-m6lkrehi 4196 23 aid aid NN cord-335975-m6lkrehi 4196 24 , , , cord-335975-m6lkrehi 4196 25 time time NN cord-335975-m6lkrehi 4196 26 limit limit NN cord-335975-m6lkrehi 4196 27 for for IN cord-335975-m6lkrehi 4196 28 admission admission NN cord-335975-m6lkrehi 4196 29 to to IN cord-335975-m6lkrehi 4196 30 pediatric pediatric JJ cord-335975-m6lkrehi 4196 31 intensive intensive JJ cord-335975-m6lkrehi 4196 32 care care NN cord-335975-m6lkrehi 4196 33 , , , cord-335975-m6lkrehi 4196 34 and and CC cord-335975-m6lkrehi 4196 35 severity severity NN cord-335975-m6lkrehi 4196 36 criteria criterion NNS cord-335975-m6lkrehi 4196 37 . . . cord-335975-m6lkrehi 4197 1 Results result NNS cord-335975-m6lkrehi 4197 2 : : : cord-335975-m6lkrehi 4197 3 57 57 CD cord-335975-m6lkrehi 4197 4 % % NN cord-335975-m6lkrehi 4197 5 of of IN cord-335975-m6lkrehi 4197 6 these these DT cord-335975-m6lkrehi 4197 7 cases case NNS cord-335975-m6lkrehi 4197 8 were be VBD cord-335975-m6lkrehi 4197 9 boys boy NNS cord-335975-m6lkrehi 4197 10 and and CC cord-335975-m6lkrehi 4197 11 43 43 CD cord-335975-m6lkrehi 4197 12 % % NN cord-335975-m6lkrehi 4197 13 girls girl NNS cord-335975-m6lkrehi 4197 14 . . . cord-335975-m6lkrehi 4198 1 The the DT cord-335975-m6lkrehi 4198 2 mediane mediane NNS cord-335975-m6lkrehi 4198 3 age age NN cord-335975-m6lkrehi 4198 4 6.5 6.5 CD cord-335975-m6lkrehi 4198 5 90 90 CD cord-335975-m6lkrehi 4198 6 % % NN cord-335975-m6lkrehi 4198 7 of of IN cord-335975-m6lkrehi 4198 8 the the DT cord-335975-m6lkrehi 4198 9 punctures puncture NNS cord-335975-m6lkrehi 4198 10 occurred occur VBD cord-335975-m6lkrehi 4198 11 during during IN cord-335975-m6lkrehi 4198 12 the the DT cord-335975-m6lkrehi 4198 13 day day NN cord-335975-m6lkrehi 4198 14 , , , cord-335975-m6lkrehi 4198 15 the the DT cord-335975-m6lkrehi 4198 16 site site NN cord-335975-m6lkrehi 4198 17 of of IN cord-335975-m6lkrehi 4198 18 the the DT cord-335975-m6lkrehi 4198 19 injection injection NN cord-335975-m6lkrehi 4198 20 was be VBD cord-335975-m6lkrehi 4198 21 the the DT cord-335975-m6lkrehi 4198 22 lower low JJR cord-335975-m6lkrehi 4198 23 limb limb NN cord-335975-m6lkrehi 4198 24 in in IN cord-335975-m6lkrehi 4198 25 80 80 CD cord-335975-m6lkrehi 4198 26 % % NN cord-335975-m6lkrehi 4198 27 of of IN cord-335975-m6lkrehi 4198 28 the the DT cord-335975-m6lkrehi 4198 29 cases case NNS cord-335975-m6lkrehi 4198 30 and and CC cord-335975-m6lkrehi 4199 1 20 20 CD cord-335975-m6lkrehi 4199 2 There there EX cord-335975-m6lkrehi 4199 3 were be VBD cord-335975-m6lkrehi 4199 4 9 9 CD cord-335975-m6lkrehi 4199 5 bites bite NNS cord-335975-m6lkrehi 4199 6 scorpion scorpion NN cord-335975-m6lkrehi 4199 7 cases case NNS cord-335975-m6lkrehi 4199 8 in in IN cord-335975-m6lkrehi 4199 9 the the DT cord-335975-m6lkrehi 4199 10 west west NN cord-335975-m6lkrehi 4199 11 of of IN cord-335975-m6lkrehi 4199 12 Algeria Algeria NNP cord-335975-m6lkrehi 4199 13 and and CC cord-335975-m6lkrehi 4199 14 exactly exactly RB cord-335975-m6lkrehi 4199 15 in in IN cord-335975-m6lkrehi 4199 16 Oran Oran NNP cord-335975-m6lkrehi 4199 17 and and CC cord-335975-m6lkrehi 4199 18 Tiaret.100 tiaret.100 DT cord-335975-m6lkrehi 4199 19 of of IN cord-335975-m6lkrehi 4199 20 the the DT cord-335975-m6lkrehi 4199 21 cases case NNS cord-335975-m6lkrehi 4199 22 was be VBD cord-335975-m6lkrehi 4199 23 the the DT cord-335975-m6lkrehi 4199 24 upper upper JJ cord-335975-m6lkrehi 4199 25 limb limb NN cord-335975-m6lkrehi 4199 26 . . . cord-335975-m6lkrehi 4200 1 The the DT cord-335975-m6lkrehi 4200 2 delay delay NN cord-335975-m6lkrehi 4200 3 of of IN cord-335975-m6lkrehi 4200 4 the the DT cord-335975-m6lkrehi 4200 5 management management NN cord-335975-m6lkrehi 4200 6 was be VBD cord-335975-m6lkrehi 4200 7 from from IN cord-335975-m6lkrehi 4200 8 1 1 CD cord-335975-m6lkrehi 4200 9 to to IN cord-335975-m6lkrehi 4200 10 3 3 CD cord-335975-m6lkrehi 4200 11 h h NN cord-335975-m6lkrehi 4200 12 for for IN cord-335975-m6lkrehi 4200 13 30 30 CD cord-335975-m6lkrehi 4200 14 100 100 CD cord-335975-m6lkrehi 4200 15 of of IN cord-335975-m6lkrehi 4200 16 the the DT cord-335975-m6lkrehi 4200 17 cases case NNS cord-335975-m6lkrehi 4200 18 who who WP cord-335975-m6lkrehi 4200 19 were be VBD cord-335975-m6lkrehi 4200 20 classified classify VBN cord-335975-m6lkrehi 4200 21 in in IN cord-335975-m6lkrehi 4200 22 the the DT cord-335975-m6lkrehi 4200 23 third third JJ cord-335975-m6lkrehi 4200 24 classed classed JJ cord-335975-m6lkrehi 4200 25 according accord VBG cord-335975-m6lkrehi 4200 26 to to IN cord-335975-m6lkrehi 4200 27 the the DT cord-335975-m6lkrehi 4200 28 clinical clinical JJ cord-335975-m6lkrehi 4200 29 signs sign NNS cord-335975-m6lkrehi 4200 30 of of IN cord-335975-m6lkrehi 4200 31 gravity gravity NN cord-335975-m6lkrehi 4200 32 . . . cord-335975-m6lkrehi 4201 1 The the DT cord-335975-m6lkrehi 4201 2 type type NN cord-335975-m6lkrehi 4201 3 of of IN cord-335975-m6lkrehi 4201 4 the the DT cord-335975-m6lkrehi 4201 5 scorpion scorpion NN cord-335975-m6lkrehi 4201 6 was be VBD cord-335975-m6lkrehi 4201 7 not not RB cord-335975-m6lkrehi 4201 8 identified identify VBN cord-335975-m6lkrehi 4201 9 . . . cord-335975-m6lkrehi 4202 1 We -PRON- PRP cord-335975-m6lkrehi 4202 2 can can MD cord-335975-m6lkrehi 4202 3 classify classify VB cord-335975-m6lkrehi 4202 4 all all PDT cord-335975-m6lkrehi 4202 5 the the DT cord-335975-m6lkrehi 4202 6 patients patient NNS cord-335975-m6lkrehi 4202 7 that that WDT cord-335975-m6lkrehi 4202 8 we -PRON- PRP cord-335975-m6lkrehi 4202 9 received receive VBD cord-335975-m6lkrehi 4202 10 in in IN cord-335975-m6lkrehi 4202 11 our -PRON- PRP$ cord-335975-m6lkrehi 4202 12 service service NN cord-335975-m6lkrehi 4202 13 into into IN cord-335975-m6lkrehi 4202 14 three three CD cord-335975-m6lkrehi 4202 15 classes class NNS cord-335975-m6lkrehi 4202 16 −43 −43 NNP cord-335975-m6lkrehi 4202 17 % % NN cord-335975-m6lkrehi 4202 18 in in IN cord-335975-m6lkrehi 4202 19 class class NN cord-335975-m6lkrehi 4203 1 I -PRON- PRP cord-335975-m6lkrehi 4203 2 , , , cord-335975-m6lkrehi 4203 3 with with IN cord-335975-m6lkrehi 4203 4 local local JJ cord-335975-m6lkrehi 4203 5 signs sign NNS cord-335975-m6lkrehi 4203 6 such such JJ cord-335975-m6lkrehi 4203 7 as as IN cord-335975-m6lkrehi 4203 8 pruritus pruritus NN cord-335975-m6lkrehi 4203 9 , , , cord-335975-m6lkrehi 4203 10 redness redness NN cord-335975-m6lkrehi 4203 11 , , , cord-335975-m6lkrehi 4203 12 abnormalities abnormality NNS cord-335975-m6lkrehi 4203 13 and and CC cord-335975-m6lkrehi 4203 14 local local JJ cord-335975-m6lkrehi 4203 15 pain pain NN cord-335975-m6lkrehi 4203 16 . . . cord-335975-m6lkrehi 4204 1 EVA EVA NNP cord-335975-m6lkrehi 4204 2 6 6 CD cord-335975-m6lkrehi 4204 3 - - SYM cord-335975-m6lkrehi 4204 4 7 7 CD cord-335975-m6lkrehi 4204 5 , , , cord-335975-m6lkrehi 4204 6 calmed calm VBN cord-335975-m6lkrehi 4204 7 by by IN cord-335975-m6lkrehi 4204 8 the the DT cord-335975-m6lkrehi 4204 9 infusion infusion NN cord-335975-m6lkrehi 4204 10 of of IN cord-335975-m6lkrehi 4204 11 15 15 CD cord-335975-m6lkrehi 4204 12 mg mg NNP cord-335975-m6lkrehi 4204 13 kg kg NNP cord-335975-m6lkrehi 4204 14 iv iv CD cord-335975-m6lkrehi 4204 15 of of IN cord-335975-m6lkrehi 4204 16 paracetamol paracetamol NNP cord-335975-m6lkrehi 4204 17 and and CC cord-335975-m6lkrehi 4204 18 application application NNP cord-335975-m6lkrehi 4204 19 of of IN cord-335975-m6lkrehi 4204 20 xylocaine xylocaine NNP cord-335975-m6lkrehi 4204 21 cream cream NN cord-335975-m6lkrehi 4204 22 at at IN cord-335975-m6lkrehi 4204 23 the the DT cord-335975-m6lkrehi 4204 24 site site NN cord-335975-m6lkrehi 4204 25 of of IN cord-335975-m6lkrehi 4204 26 the the DT cord-335975-m6lkrehi 4204 27 sting sting NN cord-335975-m6lkrehi 4204 28 . . . cord-335975-m6lkrehi 4205 1 Introduction introduction NN cord-335975-m6lkrehi 4205 2 : : : cord-335975-m6lkrehi 4206 1 The the DT cord-335975-m6lkrehi 4206 2 residence residence NN cord-335975-m6lkrehi 4206 3 of of IN cord-335975-m6lkrehi 4206 4 children child NNS cord-335975-m6lkrehi 4206 5 in in IN cord-335975-m6lkrehi 4206 6 intensive intensive JJ cord-335975-m6lkrehi 4206 7 care care NN cord-335975-m6lkrehi 4206 8 is be VBZ cord-335975-m6lkrehi 4206 9 most most RBS cord-335975-m6lkrehi 4206 10 often often RB cord-335975-m6lkrehi 4206 11 due due JJ cord-335975-m6lkrehi 4206 12 to to IN cord-335975-m6lkrehi 4206 13 the the DT cord-335975-m6lkrehi 4206 14 existence existence NN cord-335975-m6lkrehi 4206 15 of of IN cord-335975-m6lkrehi 4206 16 one one CD cord-335975-m6lkrehi 4206 17 or or CC cord-335975-m6lkrehi 4206 18 more more JJR cord-335975-m6lkrehi 4206 19 organ organ NN cord-335975-m6lkrehi 4206 20 dysfunction dysfunction NN cord-335975-m6lkrehi 4206 21 which which WDT cord-335975-m6lkrehi 4206 22 requires require VBZ cord-335975-m6lkrehi 4206 23 heavy heavy JJ cord-335975-m6lkrehi 4206 24 treatment treatment NN cord-335975-m6lkrehi 4206 25 ( ( -LRB- cord-335975-m6lkrehi 4206 26 intubation intubation NN cord-335975-m6lkrehi 4206 27 , , , cord-335975-m6lkrehi 4206 28 ventilation ventilation NN cord-335975-m6lkrehi 4206 29 , , , cord-335975-m6lkrehi 4206 30 drainage drainage NN cord-335975-m6lkrehi 4206 31 , , , cord-335975-m6lkrehi 4206 32 venous venous JJ cord-335975-m6lkrehi 4206 33 tract tract NN cord-335975-m6lkrehi 4206 34 ) ) -RRB- cord-335975-m6lkrehi 4206 35 and and CC cord-335975-m6lkrehi 4206 36 this this DT cord-335975-m6lkrehi 4206 37 in in IN cord-335975-m6lkrehi 4206 38 a a DT cord-335975-m6lkrehi 4206 39 hostile hostile JJ cord-335975-m6lkrehi 4206 40 environment environment NN cord-335975-m6lkrehi 4206 41 which which WDT cord-335975-m6lkrehi 4206 42 amplifies amplify VBZ cord-335975-m6lkrehi 4206 43 the the DT cord-335975-m6lkrehi 4206 44 aggression aggression NN cord-335975-m6lkrehi 4206 45 organic organic JJ cord-335975-m6lkrehi 4206 46 . . . cord-335975-m6lkrehi 4207 1 The the DT cord-335975-m6lkrehi 4207 2 main main JJ cord-335975-m6lkrehi 4207 3 objective objective NN cord-335975-m6lkrehi 4207 4 of of IN cord-335975-m6lkrehi 4207 5 our -PRON- PRP$ cord-335975-m6lkrehi 4207 6 work work NN cord-335975-m6lkrehi 4207 7 is be VBZ cord-335975-m6lkrehi 4207 8 to to TO cord-335975-m6lkrehi 4207 9 study study VB cord-335975-m6lkrehi 4207 10 the the DT cord-335975-m6lkrehi 4207 11 consequences consequence NNS cord-335975-m6lkrehi 4207 12 of of IN cord-335975-m6lkrehi 4207 13 hospitalization hospitalization NN cord-335975-m6lkrehi 4207 14 of of IN cord-335975-m6lkrehi 4207 15 children child NNS cord-335975-m6lkrehi 4207 16 in in IN cord-335975-m6lkrehi 4207 17 pediatric pediatric JJ cord-335975-m6lkrehi 4207 18 resuscitation resuscitation NN cord-335975-m6lkrehi 4207 19 . . . cord-335975-m6lkrehi 4208 1 Patients patient NNS cord-335975-m6lkrehi 4208 2 and and CC cord-335975-m6lkrehi 4208 3 methods method NNS cord-335975-m6lkrehi 4209 1 : : : cord-335975-m6lkrehi 4209 2 This this DT cord-335975-m6lkrehi 4209 3 is be VBZ cord-335975-m6lkrehi 4209 4 a a DT cord-335975-m6lkrehi 4209 5 descriptive descriptive JJ cord-335975-m6lkrehi 4209 6 prospective prospective JJ cord-335975-m6lkrehi 4209 7 study study NN cord-335975-m6lkrehi 4209 8 on on IN cord-335975-m6lkrehi 4209 9 the the DT cord-335975-m6lkrehi 4209 10 outpatient outpatient NN cord-335975-m6lkrehi 4209 11 consultation consultation NN cord-335975-m6lkrehi 4209 12 file file NN cord-335975-m6lkrehi 4209 13 of of IN cord-335975-m6lkrehi 4209 14 Canastel Canastel NNP cord-335975-m6lkrehi 4209 15 's 's POS cord-335975-m6lkrehi 4209 16 EHS EHS NNP cord-335975-m6lkrehi 4209 17 Multipurpose Multipurpose NNP cord-335975-m6lkrehi 4209 18 Resuscitation Resuscitation NNP cord-335975-m6lkrehi 4209 19 . . . cord-335975-m6lkrehi 4210 1 We -PRON- PRP cord-335975-m6lkrehi 4210 2 studied study VBD cord-335975-m6lkrehi 4210 3 18 18 CD cord-335975-m6lkrehi 4210 4 files file NNS cord-335975-m6lkrehi 4210 5 and and CC cord-335975-m6lkrehi 4210 6 assessed assess VBN cord-335975-m6lkrehi 4210 7 memory memory NN cord-335975-m6lkrehi 4210 8 , , , cord-335975-m6lkrehi 4210 9 perception perception NN cord-335975-m6lkrehi 4210 10 of of IN cord-335975-m6lkrehi 4210 11 contact contact NN cord-335975-m6lkrehi 4210 12 and and CC cord-335975-m6lkrehi 4210 13 nuisance nuisance NN cord-335975-m6lkrehi 4210 14 factors factor NNS cord-335975-m6lkrehi 4210 15 felt feel VBN cord-335975-m6lkrehi 4210 16 by by IN cord-335975-m6lkrehi 4210 17 sick sick JJ cord-335975-m6lkrehi 4210 18 children child NNS cord-335975-m6lkrehi 4210 19 . . . cord-335975-m6lkrehi 4211 1 Results result NNS cord-335975-m6lkrehi 4211 2 : : : cord-335975-m6lkrehi 4212 1 Out out IN cord-335975-m6lkrehi 4212 2 of of IN cord-335975-m6lkrehi 4212 3 18 18 CD cord-335975-m6lkrehi 4212 4 children child NNS cord-335975-m6lkrehi 4212 5 seen see VBN cord-335975-m6lkrehi 4212 6 in in IN cord-335975-m6lkrehi 4212 7 post post JJ cord-335975-m6lkrehi 4212 8 resuscitation resuscitation NN cord-335975-m6lkrehi 4212 9 . . . cord-335975-m6lkrehi 4213 1 The the DT cord-335975-m6lkrehi 4213 2 sex sex NN cord-335975-m6lkrehi 4213 3 ratio ratio NN cord-335975-m6lkrehi 4213 4 is be VBZ cord-335975-m6lkrehi 4213 5 1.25 1.25 CD cord-335975-m6lkrehi 4213 6 . . . cord-335975-m6lkrehi 4214 1 The the DT cord-335975-m6lkrehi 4214 2 average average JJ cord-335975-m6lkrehi 4214 3 age age NN cord-335975-m6lkrehi 4214 4 of of IN cord-335975-m6lkrehi 4214 5 children child NNS cord-335975-m6lkrehi 4214 6 is be VBZ cord-335975-m6lkrehi 4214 7 4 4 CD cord-335975-m6lkrehi 4214 8 years year NNS cord-335975-m6lkrehi 4214 9 ( ( -LRB- cord-335975-m6lkrehi 4214 10 2 2 CD cord-335975-m6lkrehi 4214 11 months-14 months-14 CD cord-335975-m6lkrehi 4214 12 years year NNS cord-335975-m6lkrehi 4214 13 ) ) -RRB- cord-335975-m6lkrehi 4214 14 . . . cord-335975-m6lkrehi 4215 1 The the DT cord-335975-m6lkrehi 4215 2 average average JJ cord-335975-m6lkrehi 4215 3 hospital hospital NN cord-335975-m6lkrehi 4215 4 stay stay NN cord-335975-m6lkrehi 4215 5 is be VBZ cord-335975-m6lkrehi 4215 6 13 13 CD cord-335975-m6lkrehi 4215 7 days day NNS cord-335975-m6lkrehi 4215 8 . . . cord-335975-m6lkrehi 4216 1 The the DT cord-335975-m6lkrehi 4216 2 average average JJ cord-335975-m6lkrehi 4216 3 GOS GOS NNP cord-335975-m6lkrehi 4216 4 ( ( -LRB- cord-335975-m6lkrehi 4216 5 Glasgow Glasgow NNP cord-335975-m6lkrehi 4216 6 out out IN cord-335975-m6lkrehi 4216 7 scale scale NN cord-335975-m6lkrehi 4216 8 ) ) -RRB- cord-335975-m6lkrehi 4216 9 is be VBZ cord-335975-m6lkrehi 4216 10 4 4 CD cord-335975-m6lkrehi 4216 11 . . . cord-335975-m6lkrehi 4217 1 ( ( -LRB- cord-335975-m6lkrehi 4217 2 2 2 LS cord-335975-m6lkrehi 4217 3 ) ) -RRB- cord-335975-m6lkrehi 4217 4 ( ( -LRB- cord-335975-m6lkrehi 4217 5 3 3 LS cord-335975-m6lkrehi 4217 6 ) ) -RRB- cord-335975-m6lkrehi 4217 7 ( ( -LRB- cord-335975-m6lkrehi 4217 8 4 4 LS cord-335975-m6lkrehi 4217 9 ) ) -RRB- cord-335975-m6lkrehi 4217 10 ( ( -LRB- cord-335975-m6lkrehi 4217 11 5 5 CD cord-335975-m6lkrehi 4217 12 ) ) -RRB- cord-335975-m6lkrehi 4217 13 . . . cord-335975-m6lkrehi 4218 1 The the DT cord-335975-m6lkrehi 4218 2 average average JJ cord-335975-m6lkrehi 4218 3 duration duration NN cord-335975-m6lkrehi 4218 4 of of IN cord-335975-m6lkrehi 4218 5 ventilation ventilation NN cord-335975-m6lkrehi 4218 6 is be VBZ cord-335975-m6lkrehi 4218 7 8 8 CD cord-335975-m6lkrehi 4218 8 days day NNS cord-335975-m6lkrehi 4218 9 . . . cord-335975-m6lkrehi 4219 1 60 60 CD cord-335975-m6lkrehi 4219 2 % % NN cord-335975-m6lkrehi 4219 3 of of IN cord-335975-m6lkrehi 4219 4 children child NNS cord-335975-m6lkrehi 4219 5 had have VBD cord-335975-m6lkrehi 4219 6 central central JJ cord-335975-m6lkrehi 4219 7 vascular vascular JJ cord-335975-m6lkrehi 4219 8 access access NN cord-335975-m6lkrehi 4219 9 . . . cord-335975-m6lkrehi 4220 1 Three three CD cord-335975-m6lkrehi 4220 2 children child NNS cord-335975-m6lkrehi 4220 3 describe describe VBP cord-335975-m6lkrehi 4220 4 a a DT cord-335975-m6lkrehi 4220 5 total total JJ cord-335975-m6lkrehi 4220 6 memory memory NN cord-335975-m6lkrehi 4220 7 of of IN cord-335975-m6lkrehi 4220 8 the the DT cord-335975-m6lkrehi 4220 9 stay stay NN cord-335975-m6lkrehi 4220 10 , , , cord-335975-m6lkrehi 4220 11 2 2 CD cord-335975-m6lkrehi 4220 12 some some DT cord-335975-m6lkrehi 4220 13 memory memory NN cord-335975-m6lkrehi 4220 14 and and CC cord-335975-m6lkrehi 4220 15 2 2 CD cord-335975-m6lkrehi 4220 16 none none NN cord-335975-m6lkrehi 4220 17 . . . cord-335975-m6lkrehi 4221 1 Three three CD cord-335975-m6lkrehi 4221 2 children child NNS cord-335975-m6lkrehi 4221 3 have have VBP cord-335975-m6lkrehi 4221 4 a a DT cord-335975-m6lkrehi 4221 5 good good JJ cord-335975-m6lkrehi 4221 6 perception perception NN cord-335975-m6lkrehi 4221 7 about about IN cord-335975-m6lkrehi 4221 8 the the DT cord-335975-m6lkrehi 4221 9 staff staff NN cord-335975-m6lkrehi 4221 10 , , , cord-335975-m6lkrehi 4221 11 one one CD cord-335975-m6lkrehi 4221 12 child child NN cord-335975-m6lkrehi 4221 13 dissatisfied dissatisfy VBN cord-335975-m6lkrehi 4221 14 and and CC cord-335975-m6lkrehi 4221 15 three three CD cord-335975-m6lkrehi 4221 16 others other NNS cord-335975-m6lkrehi 4221 17 indifferent indifferent JJ cord-335975-m6lkrehi 4221 18 . . . cord-335975-m6lkrehi 4222 1 The the DT cord-335975-m6lkrehi 4222 2 nuisance nuisance NN cord-335975-m6lkrehi 4222 3 factors factor NNS cord-335975-m6lkrehi 4222 4 described describe VBN cord-335975-m6lkrehi 4222 5 by by IN cord-335975-m6lkrehi 4222 6 the the DT cord-335975-m6lkrehi 4222 7 children child NNS cord-335975-m6lkrehi 4222 8 are be VBP cord-335975-m6lkrehi 4222 9 pain pain NN cord-335975-m6lkrehi 4222 10 ( ( -LRB- cord-335975-m6lkrehi 4222 11 3 3 CD cord-335975-m6lkrehi 4222 12 ) ) -RRB- cord-335975-m6lkrehi 4222 13 , , , cord-335975-m6lkrehi 4222 14 cold cold JJ cord-335975-m6lkrehi 4222 15 ( ( -LRB- cord-335975-m6lkrehi 4222 16 2 2 CD cord-335975-m6lkrehi 4222 17 ) ) -RRB- cord-335975-m6lkrehi 4222 18 , , , cord-335975-m6lkrehi 4222 19 noise noise NN cord-335975-m6lkrehi 4222 20 ( ( -LRB- cord-335975-m6lkrehi 4222 21 3 3 CD cord-335975-m6lkrehi 4222 22 ) ) -RRB- cord-335975-m6lkrehi 4222 23 , , , cord-335975-m6lkrehi 4222 24 hunger hunger NN cord-335975-m6lkrehi 4222 25 ( ( -LRB- cord-335975-m6lkrehi 4222 26 1 1 CD cord-335975-m6lkrehi 4222 27 ) ) -RRB- cord-335975-m6lkrehi 4222 28 and and CC cord-335975-m6lkrehi 4222 29 light light NN cord-335975-m6lkrehi 4222 30 ( ( -LRB- cord-335975-m6lkrehi 4222 31 1 1 CD cord-335975-m6lkrehi 4222 32 ) ) -RRB- cord-335975-m6lkrehi 4222 33 . . . cord-335975-m6lkrehi 4223 1 Conclusion conclusion NN cord-335975-m6lkrehi 4223 2 : : : cord-335975-m6lkrehi 4223 3 Consequences consequence NNS cord-335975-m6lkrehi 4223 4 of of IN cord-335975-m6lkrehi 4223 5 psychological psychological JJ cord-335975-m6lkrehi 4223 6 trauma trauma NN cord-335975-m6lkrehi 4223 7 , , , cord-335975-m6lkrehi 4223 8 insufficiently insufficiently RB cord-335975-m6lkrehi 4223 9 evaluated evaluate VBN cord-335975-m6lkrehi 4223 10 especially especially RB cord-335975-m6lkrehi 4223 11 by by IN cord-335975-m6lkrehi 4223 12 the the DT cord-335975-m6lkrehi 4223 13 staff staff NN cord-335975-m6lkrehi 4223 14 , , , cord-335975-m6lkrehi 4223 15 which which WDT cord-335975-m6lkrehi 4223 16 result result VBP cord-335975-m6lkrehi 4223 17 in in IN cord-335975-m6lkrehi 4223 18 the the DT cord-335975-m6lkrehi 4223 19 appearance appearance NN cord-335975-m6lkrehi 4223 20 of of IN cord-335975-m6lkrehi 4223 21 psychological psychological JJ cord-335975-m6lkrehi 4223 22 disorders disorder NNS cord-335975-m6lkrehi 4223 23 ( ( -LRB- cord-335975-m6lkrehi 4223 24 nightmares nightmare NNS cord-335975-m6lkrehi 4223 25 and and CC cord-335975-m6lkrehi 4223 26 anxiety anxiety NN cord-335975-m6lkrehi 4223 27 ) ) -RRB- cord-335975-m6lkrehi 4223 28 with with IN cord-335975-m6lkrehi 4223 29 sometimes sometimes RB cord-335975-m6lkrehi 4223 30 even even RB cord-335975-m6lkrehi 4223 31 severe severe JJ cord-335975-m6lkrehi 4223 32 post post JJ cord-335975-m6lkrehi 4223 33 - - JJ cord-335975-m6lkrehi 4223 34 traumatic traumatic JJ cord-335975-m6lkrehi 4223 35 neurosis neurosis NN cord-335975-m6lkrehi 4223 36 . . . cord-335975-m6lkrehi 4224 1 Hence hence RB cord-335975-m6lkrehi 4224 2 the the DT cord-335975-m6lkrehi 4224 3 need need NN cord-335975-m6lkrehi 4224 4 to to TO cord-335975-m6lkrehi 4224 5 adapt adapt VB cord-335975-m6lkrehi 4224 6 the the DT cord-335975-m6lkrehi 4224 7 environment environment NN cord-335975-m6lkrehi 4224 8 and and CC cord-335975-m6lkrehi 4224 9 mainly mainly RB cord-335975-m6lkrehi 4224 10 noise noise NN cord-335975-m6lkrehi 4224 11 and and CC cord-335975-m6lkrehi 4224 12 respect respect NN cord-335975-m6lkrehi 4224 13 for for IN cord-335975-m6lkrehi 4224 14 sleep sleep NN cord-335975-m6lkrehi 4224 15 . . . cord-335975-m6lkrehi 4225 1 [ [ -LRB- cord-335975-m6lkrehi 4225 2 3 3 CD cord-335975-m6lkrehi 4225 3 ] ] -RRB- cord-335975-m6lkrehi 4225 4 [ [ -LRB- cord-335975-m6lkrehi 4225 5 4 4 CD cord-335975-m6lkrehi 4225 6 ] ] -RRB- cord-335975-m6lkrehi 4225 7 [ [ -LRB- cord-335975-m6lkrehi 4225 8 5 5 CD cord-335975-m6lkrehi 4225 9 ] ] -RRB- cord-335975-m6lkrehi 4225 10 [ [ -LRB- cord-335975-m6lkrehi 4225 11 6 6 CD cord-335975-m6lkrehi 4225 12 ] ] -RRB- cord-335975-m6lkrehi 4225 13 [ [ -LRB- cord-335975-m6lkrehi 4225 14 7 7 CD cord-335975-m6lkrehi 4225 15 ] ] -RRB- cord-335975-m6lkrehi 4226 1 [ [ -LRB- cord-335975-m6lkrehi 4226 2 8 8 CD cord-335975-m6lkrehi 4226 3 ] ] -RRB- cord-335975-m6lkrehi 4226 4 [ [ -LRB- cord-335975-m6lkrehi 4226 5 9 9 CD cord-335975-m6lkrehi 4226 6 ] ] -RRB- cord-335975-m6lkrehi 4226 7 . . . cord-335975-m6lkrehi 4227 1 The the DT cord-335975-m6lkrehi 4227 2 median median JJ cord-335975-m6lkrehi 4227 3 treatment treatment NN cord-335975-m6lkrehi 4227 4 duration duration NN cord-335975-m6lkrehi 4227 5 time time NN cord-335975-m6lkrehi 4227 6 was be VBD cord-335975-m6lkrehi 4227 7 at at IN cord-335975-m6lkrehi 4227 8 120(87 120(87 CD cord-335975-m6lkrehi 4227 9 - - SYM cord-335975-m6lkrehi 4227 10 180 180 CD cord-335975-m6lkrehi 4227 11 ) ) -RRB- cord-335975-m6lkrehi 4227 12 minutes minute NNS cord-335975-m6lkrehi 4227 13 . . . cord-335975-m6lkrehi 4228 1 Femoral femoral JJ cord-335975-m6lkrehi 4228 2 vein vein NN cord-335975-m6lkrehi 4228 3 was be VBD cord-335975-m6lkrehi 4228 4 used use VBN cord-335975-m6lkrehi 4228 5 as as IN cord-335975-m6lkrehi 4228 6 vascular vascular JJ cord-335975-m6lkrehi 4228 7 access access NN cord-335975-m6lkrehi 4228 8 ( ( -LRB- cord-335975-m6lkrehi 4228 9 93 93 CD cord-335975-m6lkrehi 4228 10 % % NN cord-335975-m6lkrehi 4228 11 ) ) -RRB- cord-335975-m6lkrehi 4228 12 and and CC cord-335975-m6lkrehi 4228 13 most most JJS cord-335975-m6lkrehi 4228 14 of of IN cord-335975-m6lkrehi 4228 15 PE PE NNP cord-335975-m6lkrehi 4228 16 procedures procedure NNS cord-335975-m6lkrehi 4228 17 ( ( -LRB- cord-335975-m6lkrehi 4228 18 78 78 CD cord-335975-m6lkrehi 4228 19 % % NN cord-335975-m6lkrehi 4228 20 ) ) -RRB- cord-335975-m6lkrehi 4228 21 were be VBD cord-335975-m6lkrehi 4228 22 performed perform VBN cord-335975-m6lkrehi 4228 23 with with IN cord-335975-m6lkrehi 4228 24 citrate citrate NN cord-335975-m6lkrehi 4228 25 anticoagulation anticoagulation NN cord-335975-m6lkrehi 4228 26 . . . cord-335975-m6lkrehi 4229 1 Median median JJ cord-335975-m6lkrehi 4229 2 exchange exchange NN cord-335975-m6lkrehi 4229 3 volume volume NN cord-335975-m6lkrehi 4229 4 was be VBD cord-335975-m6lkrehi 4229 5 at at IN cord-335975-m6lkrehi 4229 6 3500 3500 CD cord-335975-m6lkrehi 4229 7 [ [ -LRB- cord-335975-m6lkrehi 4229 8 2796 2796 CD cord-335975-m6lkrehi 4229 9 - - HYPH cord-335975-m6lkrehi 4229 10 4190 4190 CD cord-335975-m6lkrehi 4229 11 ] ] -RRB- cord-335975-m6lkrehi 4229 12 ml ml NNS cord-335975-m6lkrehi 4229 13 and and CC cord-335975-m6lkrehi 4229 14 renal renal JJ cord-335975-m6lkrehi 4229 15 replacement replacement NN cord-335975-m6lkrehi 4229 16 fluid fluid NN cord-335975-m6lkrehi 4229 17 was be VBD cord-335975-m6lkrehi 4229 18 fresh fresh JJ cord-335975-m6lkrehi 4229 19 frozen frozen JJ cord-335975-m6lkrehi 4229 20 plasma plasma NN cord-335975-m6lkrehi 4229 21 ( ( -LRB- cord-335975-m6lkrehi 4229 22 FFP FFP NNP cord-335975-m6lkrehi 4229 23 ) ) -RRB- cord-335975-m6lkrehi 4229 24 in in IN cord-335975-m6lkrehi 4229 25 64 64 CD cord-335975-m6lkrehi 4229 26 % % NN cord-335975-m6lkrehi 4229 27 , , , cord-335975-m6lkrehi 4229 28 50 50 CD cord-335975-m6lkrehi 4229 29 % % NN cord-335975-m6lkrehi 4229 30 FFP ffp NN cord-335975-m6lkrehi 4229 31 and and CC cord-335975-m6lkrehi 4229 32 50 50 CD cord-335975-m6lkrehi 4229 33 % % NN cord-335975-m6lkrehi 4229 34 human human JJ cord-335975-m6lkrehi 4229 35 albumin albumin NN cord-335975-m6lkrehi 4229 36 4 4 CD cord-335975-m6lkrehi 4229 37 % % NN cord-335975-m6lkrehi 4229 38 in in IN cord-335975-m6lkrehi 4229 39 22 22 CD cord-335975-m6lkrehi 4229 40 % % NN cord-335975-m6lkrehi 4229 41 and and CC cord-335975-m6lkrehi 4229 42 human human JJ cord-335975-m6lkrehi 4229 43 albumin albumin NN cord-335975-m6lkrehi 4229 44 only only RB cord-335975-m6lkrehi 4229 45 in in IN cord-335975-m6lkrehi 4229 46 14 14 CD cord-335975-m6lkrehi 4229 47 % % NN cord-335975-m6lkrehi 4229 48 of of IN cord-335975-m6lkrehi 4229 49 procedures procedure NNS cord-335975-m6lkrehi 4229 50 . . . cord-335975-m6lkrehi 4230 1 Adverse adverse JJ cord-335975-m6lkrehi 4230 2 effects effect NNS cord-335975-m6lkrehi 4230 3 were be VBD cord-335975-m6lkrehi 4230 4 observed observe VBN cord-335975-m6lkrehi 4230 5 in in IN cord-335975-m6lkrehi 4230 6 less less JJR cord-335975-m6lkrehi 4230 7 than than IN cord-335975-m6lkrehi 4230 8 20 20 CD cord-335975-m6lkrehi 4230 9 % % NN cord-335975-m6lkrehi 4230 10 of of IN cord-335975-m6lkrehi 4230 11 procedures procedure NNS cord-335975-m6lkrehi 4230 12 and and CC cord-335975-m6lkrehi 4230 13 10 10 CD cord-335975-m6lkrehi 4230 14 % % NN cord-335975-m6lkrehi 4230 15 were be VBD cord-335975-m6lkrehi 4230 16 lifethreathening lifethreathene VBG cord-335975-m6lkrehi 4230 17 including include VBG cord-335975-m6lkrehi 4230 18 cardiac cardiac JJ cord-335975-m6lkrehi 4230 19 arrest arrest NN cord-335975-m6lkrehi 4230 20 , , , cord-335975-m6lkrehi 4230 21 heart heart NN cord-335975-m6lkrehi 4230 22 rhythm rhythm NN cord-335975-m6lkrehi 4230 23 disorders disorder NNS cord-335975-m6lkrehi 4230 24 , , , cord-335975-m6lkrehi 4230 25 cerebral cerebral JJ cord-335975-m6lkrehi 4230 26 oedema oedema NN cord-335975-m6lkrehi 4230 27 and and CC cord-335975-m6lkrehi 4230 28 hemolysis hemolysis NN cord-335975-m6lkrehi 4230 29 . . . cord-335975-m6lkrehi 4231 1 Other other JJ cord-335975-m6lkrehi 4231 2 remaining remain VBG cord-335975-m6lkrehi 4231 3 complications complication NNS cord-335975-m6lkrehi 4231 4 were be VBD cord-335975-m6lkrehi 4231 5 secondary secondary JJ cord-335975-m6lkrehi 4231 6 infections infection NNS cord-335975-m6lkrehi 4231 7 48 48 CD cord-335975-m6lkrehi 4231 8 % % NN cord-335975-m6lkrehi 4231 9 , , , cord-335975-m6lkrehi 4231 10 hemorrhage hemorrhage NN cord-335975-m6lkrehi 4231 11 23 23 CD cord-335975-m6lkrehi 4231 12 % % NN cord-335975-m6lkrehi 4231 13 , , , cord-335975-m6lkrehi 4231 14 and and CC cord-335975-m6lkrehi 4231 15 pulmonary pulmonary JJ cord-335975-m6lkrehi 4231 16 oedema oedema NN cord-335975-m6lkrehi 4231 17 14 14 CD cord-335975-m6lkrehi 4231 18 % % NN cord-335975-m6lkrehi 4231 19 in in IN cord-335975-m6lkrehi 4231 20 all all DT cord-335975-m6lkrehi 4231 21 patients patient NNS cord-335975-m6lkrehi 4231 22 . . . cord-335975-m6lkrehi 4232 1 Twenty twenty CD cord-335975-m6lkrehi 4232 2 patients patient NNS cord-335975-m6lkrehi 4232 3 deceaded deceade VBD cord-335975-m6lkrehi 4232 4 ( ( -LRB- cord-335975-m6lkrehi 4232 5 ICU ICU NNP cord-335975-m6lkrehi 4232 6 mortality mortality NN cord-335975-m6lkrehi 4232 7 26 26 CD cord-335975-m6lkrehi 4232 8 % % NN cord-335975-m6lkrehi 4232 9 ) ) -RRB- cord-335975-m6lkrehi 4232 10 . . . cord-335975-m6lkrehi 4233 1 ICU ICU NNP cord-335975-m6lkrehi 4233 2 and and CC cord-335975-m6lkrehi 4233 3 hospital hospital NN cord-335975-m6lkrehi 4233 4 lenght lenght NN cord-335975-m6lkrehi 4233 5 of of IN cord-335975-m6lkrehi 4233 6 stay stay NN cord-335975-m6lkrehi 4233 7 was be VBD cord-335975-m6lkrehi 4233 8 at at IN cord-335975-m6lkrehi 4233 9 19 19 CD cord-335975-m6lkrehi 4233 10 ± ± CD cord-335975-m6lkrehi 4233 11 21 21 CD cord-335975-m6lkrehi 4233 12 and and CC cord-335975-m6lkrehi 4233 13 47 47 CD cord-335975-m6lkrehi 4233 14 ± ± CD cord-335975-m6lkrehi 4233 15 33 33 CD cord-335975-m6lkrehi 4233 16 days day NNS cord-335975-m6lkrehi 4233 17 respectively respectively RB cord-335975-m6lkrehi 4233 18 . . . cord-335975-m6lkrehi 4234 1 2 2 CD cord-335975-m6lkrehi 4234 2 3 3 CD cord-335975-m6lkrehi 4234 3 of of IN cord-335975-m6lkrehi 4234 4 survived survive VBN cord-335975-m6lkrehi 4234 5 patients patient NNS cord-335975-m6lkrehi 4234 6 still still RB cord-335975-m6lkrehi 4234 7 underwent undergo VBD cord-335975-m6lkrehi 4234 8 PE PE NNP cord-335975-m6lkrehi 4234 9 after after IN cord-335975-m6lkrehi 4234 10 their -PRON- PRP$ cord-335975-m6lkrehi 4234 11 ICU ICU NNP cord-335975-m6lkrehi 4234 12 discharge discharge NN cord-335975-m6lkrehi 4234 13 + + SYM cord-335975-m6lkrehi 4234 14 9 9 CD cord-335975-m6lkrehi 4234 15 totally totally RB cord-335975-m6lkrehi 4234 16 recovered recover VBD cord-335975-m6lkrehi 4234 17 whereas whereas IN cord-335975-m6lkrehi 4234 18 49 49 CD cord-335975-m6lkrehi 4234 19 ( ( -LRB- cord-335975-m6lkrehi 4234 20 63 63 CD cord-335975-m6lkrehi 4234 21 % % NN cord-335975-m6lkrehi 4234 22 ) ) -RRB- cord-335975-m6lkrehi 4234 23 were be VBD cord-335975-m6lkrehi 4234 24 on on IN cord-335975-m6lkrehi 4234 25 partial partial JJ cord-335975-m6lkrehi 4234 26 remission remission NN cord-335975-m6lkrehi 4234 27 . . . cord-335975-m6lkrehi 4235 1 Conclusion conclusion NN cord-335975-m6lkrehi 4235 2 : : : cord-335975-m6lkrehi 4235 3 PE PE NNP cord-335975-m6lkrehi 4235 4 is be VBZ cord-335975-m6lkrehi 4235 5 a a DT cord-335975-m6lkrehi 4235 6 routine routine JJ cord-335975-m6lkrehi 4235 7 and and CC cord-335975-m6lkrehi 4235 8 feasible feasible JJ cord-335975-m6lkrehi 4235 9 technique technique NN cord-335975-m6lkrehi 4235 10 in in IN cord-335975-m6lkrehi 4235 11 ICU ICU NNP cord-335975-m6lkrehi 4235 12 . . . cord-335975-m6lkrehi 4236 1 This this DT cord-335975-m6lkrehi 4236 2 study study NN cord-335975-m6lkrehi 4236 3 showed show VBD cord-335975-m6lkrehi 4236 4 that that IN cord-335975-m6lkrehi 4236 5 TPP TPP NNP cord-335975-m6lkrehi 4236 6 was be VBD cord-335975-m6lkrehi 4236 7 the the DT cord-335975-m6lkrehi 4236 8 most most RBS cord-335975-m6lkrehi 4236 9 commonly commonly RB cord-335975-m6lkrehi 4236 10 indication indication NN cord-335975-m6lkrehi 4236 11 of of IN cord-335975-m6lkrehi 4236 12 its -PRON- PRP$ cord-335975-m6lkrehi 4236 13 use use NN cord-335975-m6lkrehi 4236 14 and and CC cord-335975-m6lkrehi 4236 15 that that DT cord-335975-m6lkrehi 4236 16 outcome outcome NN cord-335975-m6lkrehi 4236 17 was be VBD cord-335975-m6lkrehi 4236 18 fair fair JJ cord-335975-m6lkrehi 4236 19 . . . cord-335975-m6lkrehi 4237 1 Adverse adverse JJ cord-335975-m6lkrehi 4237 2 effects effect NNS cord-335975-m6lkrehi 4237 3 frequently frequently RB cord-335975-m6lkrehi 4237 4 occured occur VBD cord-335975-m6lkrehi 4237 5 but but CC cord-335975-m6lkrehi 4237 6 most most JJS cord-335975-m6lkrehi 4237 7 of of IN cord-335975-m6lkrehi 4237 8 them -PRON- PRP cord-335975-m6lkrehi 4237 9 were be VBD cord-335975-m6lkrehi 4237 10 not not RB cord-335975-m6lkrehi 4237 11 severe severe JJ cord-335975-m6lkrehi 4237 12 . . . cord-335975-m6lkrehi 4238 1 Further further JJ cord-335975-m6lkrehi 4238 2 studies study NNS cord-335975-m6lkrehi 4238 3 would would MD cord-335975-m6lkrehi 4238 4 benefit benefit VB cord-335975-m6lkrehi 4238 5 form form NN cord-335975-m6lkrehi 4238 6 larger large JJR cord-335975-m6lkrehi 4238 7 cohort cohort NN cord-335975-m6lkrehi 4238 8 to to TO cord-335975-m6lkrehi 4238 9 improve improve VB cord-335975-m6lkrehi 4238 10 indications indication NNS cord-335975-m6lkrehi 4238 11 , , , cord-335975-m6lkrehi 4238 12 delay delay NN cord-335975-m6lkrehi 4238 13 of of IN cord-335975-m6lkrehi 4238 14 initiation initiation NN cord-335975-m6lkrehi 4238 15 and and CC cord-335975-m6lkrehi 4238 16 practice practice NN cord-335975-m6lkrehi 4238 17 of of IN cord-335975-m6lkrehi 4238 18 this this DT cord-335975-m6lkrehi 4238 19 treatment treatment NN cord-335975-m6lkrehi 4238 20 . . . cord-335975-m6lkrehi 4239 1 Renal renal JJ cord-335975-m6lkrehi 4239 2 replacement replacement NN cord-335975-m6lkrehi 4239 3 therapy therapy NN cord-335975-m6lkrehi 4239 4 was be VBD cord-335975-m6lkrehi 4239 5 required require VBN cord-335975-m6lkrehi 4239 6 in in IN cord-335975-m6lkrehi 4239 7 46 46 CD cord-335975-m6lkrehi 4239 8 % % NN cord-335975-m6lkrehi 4239 9 of of IN cord-335975-m6lkrehi 4239 10 elderly elderly JJ cord-335975-m6lkrehi 4239 11 versus versus IN cord-335975-m6lkrehi 4239 12 27 27 CD cord-335975-m6lkrehi 4239 13 % % NN cord-335975-m6lkrehi 4239 14 ( ( -LRB- cord-335975-m6lkrehi 4239 15 p p NN cord-335975-m6lkrehi 4239 16 = = SYM cord-335975-m6lkrehi 4239 17 0.047 0.047 CD cord-335975-m6lkrehi 4239 18 ) ) -RRB- cord-335975-m6lkrehi 4239 19 . . . cord-335975-m6lkrehi 4240 1 Frequency frequency NN cord-335975-m6lkrehi 4240 2 of of IN cord-335975-m6lkrehi 4240 3 TTP TTP NNP cord-335975-m6lkrehi 4240 4 , , , cord-335975-m6lkrehi 4240 5 HUS HUS NNP cord-335975-m6lkrehi 4240 6 and and CC cord-335975-m6lkrehi 4240 7 aHUS ahus DT cord-335975-m6lkrehi 4240 8 was be VBD cord-335975-m6lkrehi 4240 9 similar similar JJ cord-335975-m6lkrehi 4240 10 beetween beetween NNP cord-335975-m6lkrehi 4240 11 groups group NNS cord-335975-m6lkrehi 4240 12 . . . cord-335975-m6lkrehi 4241 1 TMA TMA NNP cord-335975-m6lkrehi 4241 2 was be VBD cord-335975-m6lkrehi 4241 3 more more RBR cord-335975-m6lkrehi 4241 4 frequently frequently RB cord-335975-m6lkrehi 4241 5 associated associate VBN cord-335975-m6lkrehi 4241 6 with with IN cord-335975-m6lkrehi 4241 7 ongoing ongoing JJ cord-335975-m6lkrehi 4241 8 cancer cancer NN cord-335975-m6lkrehi 4241 9 and and CC cord-335975-m6lkrehi 4241 10 drug drug NN cord-335975-m6lkrehi 4241 11 use use NN cord-335975-m6lkrehi 4241 12 in in IN cord-335975-m6lkrehi 4241 13 elderly elderly JJ cord-335975-m6lkrehi 4241 14 ( ( -LRB- cord-335975-m6lkrehi 4241 15 39 39 CD cord-335975-m6lkrehi 4241 16 vs. vs. CC cord-335975-m6lkrehi 4241 17 8 8 CD cord-335975-m6lkrehi 4241 18 % % NN cord-335975-m6lkrehi 4241 19 , , , cord-335975-m6lkrehi 4241 20 p p NN cord-335975-m6lkrehi 4241 21 < < XX cord-335975-m6lkrehi 4241 22 0.01 0.01 CD cord-335975-m6lkrehi 4241 23 and and CC cord-335975-m6lkrehi 4241 24 23 23 CD cord-335975-m6lkrehi 4241 25 vs. vs. CC cord-335975-m6lkrehi 4241 26 6 6 CD cord-335975-m6lkrehi 4241 27 % % NN cord-335975-m6lkrehi 4241 28 , , , cord-335975-m6lkrehi 4241 29 p p NN cord-335975-m6lkrehi 4241 30 < < XX cord-335975-m6lkrehi 4241 31 0.01 0.01 CD cord-335975-m6lkrehi 4241 32 , , , cord-335975-m6lkrehi 4241 33 respectively respectively RB cord-335975-m6lkrehi 4241 34 ) ) -RRB- cord-335975-m6lkrehi 4241 35 . . . cord-335975-m6lkrehi 4242 1 Gastro gastro JJ cord-335975-m6lkrehi 4242 2 - - HYPH cord-335975-m6lkrehi 4242 3 intestinal intestinal JJ cord-335975-m6lkrehi 4242 4 bleeding bleeding NN cord-335975-m6lkrehi 4242 5 during during IN cord-335975-m6lkrehi 4242 6 ICU ICU NNP cord-335975-m6lkrehi 4242 7 occurred occur VBD cord-335975-m6lkrehi 4242 8 more more RBR cord-335975-m6lkrehi 4242 9 often often RB cord-335975-m6lkrehi 4242 10 among among IN cord-335975-m6lkrehi 4242 11 elderly elderly JJ cord-335975-m6lkrehi 4242 12 ( ( -LRB- cord-335975-m6lkrehi 4242 13 35 35 CD cord-335975-m6lkrehi 4242 14 vs. vs. CC cord-335975-m6lkrehi 4242 15 15 15 CD cord-335975-m6lkrehi 4242 16 % % NN cord-335975-m6lkrehi 4242 17 ( ( -LRB- cord-335975-m6lkrehi 4242 18 p p NN cord-335975-m6lkrehi 4242 19 = = SYM cord-335975-m6lkrehi 4242 20 0.02 0.02 CD cord-335975-m6lkrehi 4242 21 ) ) -RRB- cord-335975-m6lkrehi 4242 22 ) ) -RRB- cord-335975-m6lkrehi 4242 23 . . . cord-335975-m6lkrehi 4243 1 ICU ICU NNP cord-335975-m6lkrehi 4243 2 mortality mortality NN cord-335975-m6lkrehi 4243 3 rate rate NN cord-335975-m6lkrehi 4243 4 was be VBD cord-335975-m6lkrehi 4243 5 higher high JJR cord-335975-m6lkrehi 4243 6 ( ( -LRB- cord-335975-m6lkrehi 4243 7 19 19 CD cord-335975-m6lkrehi 4243 8 vs. vs. CC cord-335975-m6lkrehi 4243 9 7 7 CD cord-335975-m6lkrehi 4243 10 % % NN cord-335975-m6lkrehi 4243 11 , , , cord-335975-m6lkrehi 4243 12 p p NN cord-335975-m6lkrehi 4243 13 = = SYM cord-335975-m6lkrehi 4243 14 0.049 0.049 CD cord-335975-m6lkrehi 4243 15 ) ) -RRB- cord-335975-m6lkrehi 4243 16 . . . cord-335975-m6lkrehi 4244 1 No no DT cord-335975-m6lkrehi 4244 2 difference difference NN cord-335975-m6lkrehi 4244 3 was be VBD cord-335975-m6lkrehi 4244 4 found find VBN cord-335975-m6lkrehi 4244 5 concerning concern VBG cord-335975-m6lkrehi 4244 6 plasma plasma NN cord-335975-m6lkrehi 4244 7 - - HYPH cord-335975-m6lkrehi 4244 8 exchange exchange NN cord-335975-m6lkrehi 4244 9 therapy therapy NN cord-335975-m6lkrehi 4244 10 , , , cord-335975-m6lkrehi 4244 11 steroids steroid NNS cord-335975-m6lkrehi 4244 12 use use VBP cord-335975-m6lkrehi 4244 13 , , , cord-335975-m6lkrehi 4244 14 and and CC cord-335975-m6lkrehi 4244 15 rescue rescue NN cord-335975-m6lkrehi 4244 16 treatments treatment NNS cord-335975-m6lkrehi 4244 17 for for IN cord-335975-m6lkrehi 4244 18 refractory refractory JJ cord-335975-m6lkrehi 4244 19 - - HYPH cord-335975-m6lkrehi 4244 20 TTP ttp NN cord-335975-m6lkrehi 4244 21 . . . cord-335975-m6lkrehi 4245 1 Discussion discussion NN cord-335975-m6lkrehi 4245 2 : : : cord-335975-m6lkrehi 4245 3 Increased increase VBN cord-335975-m6lkrehi 4245 4 complication complication NN cord-335975-m6lkrehi 4245 5 and and CC cord-335975-m6lkrehi 4245 6 mortality mortality NN cord-335975-m6lkrehi 4245 7 rates rate NNS cord-335975-m6lkrehi 4245 8 in in IN cord-335975-m6lkrehi 4245 9 the the DT cord-335975-m6lkrehi 4245 10 elderly elderly JJ cord-335975-m6lkrehi 4245 11 group group NN cord-335975-m6lkrehi 4245 12 might may MD cord-335975-m6lkrehi 4245 13 be be VB cord-335975-m6lkrehi 4245 14 ascribed ascribe VBN cord-335975-m6lkrehi 4245 15 to to IN cord-335975-m6lkrehi 4245 16 more more RBR cord-335975-m6lkrehi 4245 17 cardiovascular cardiovascular JJ cord-335975-m6lkrehi 4245 18 morbidity morbidity NN cord-335975-m6lkrehi 4245 19 in in IN cord-335975-m6lkrehi 4245 20 this this DT cord-335975-m6lkrehi 4245 21 population population NN cord-335975-m6lkrehi 4245 22 . . . cord-335975-m6lkrehi 4246 1 The the DT cord-335975-m6lkrehi 4246 2 association association NN cord-335975-m6lkrehi 4246 3 between between IN cord-335975-m6lkrehi 4246 4 TMA TMA NNP cord-335975-m6lkrehi 4246 5 and and CC cord-335975-m6lkrehi 4246 6 ongoing ongoing JJ cord-335975-m6lkrehi 4246 7 cancer cancer NN cord-335975-m6lkrehi 4246 8 suggests suggest VBZ cord-335975-m6lkrehi 4246 9 a a DT cord-335975-m6lkrehi 4246 10 routine routine JJ cord-335975-m6lkrehi 4246 11 oncological oncological JJ cord-335975-m6lkrehi 4246 12 workup workup NN cord-335975-m6lkrehi 4246 13 among among IN cord-335975-m6lkrehi 4246 14 elderly elderly JJ cord-335975-m6lkrehi 4246 15 . . . cord-335975-m6lkrehi 4247 1 Introduction introduction NN cord-335975-m6lkrehi 4247 2 : : : cord-335975-m6lkrehi 4247 3 Neutropenia neutropenia NN cord-335975-m6lkrehi 4247 4 , , , cord-335975-m6lkrehi 4247 5 defined define VBN cord-335975-m6lkrehi 4247 6 by by IN cord-335975-m6lkrehi 4247 7 an an DT cord-335975-m6lkrehi 4247 8 absolute absolute JJ cord-335975-m6lkrehi 4247 9 count count NN cord-335975-m6lkrehi 4247 10 of of IN cord-335975-m6lkrehi 4247 11 polymorphonuclear polymorphonuclear JJ cord-335975-m6lkrehi 4247 12 neutrophils neutrophil NNS cord-335975-m6lkrehi 4247 13 less less JJR cord-335975-m6lkrehi 4247 14 than than IN cord-335975-m6lkrehi 4247 15 < < XX cord-335975-m6lkrehi 4247 16 1500 1500 CD cord-335975-m6lkrehi 4247 17 mm3 mm3 NNS cord-335975-m6lkrehi 4247 18 , , , cord-335975-m6lkrehi 4247 19 exposes expose VBZ cord-335975-m6lkrehi 4247 20 patients patient NNS cord-335975-m6lkrehi 4247 21 to to IN cord-335975-m6lkrehi 4247 22 infectious infectious JJ cord-335975-m6lkrehi 4247 23 complications complication NNS cord-335975-m6lkrehi 4247 24 that that WDT cord-335975-m6lkrehi 4247 25 can can MD cord-335975-m6lkrehi 4247 26 lead lead VB cord-335975-m6lkrehi 4247 27 to to IN cord-335975-m6lkrehi 4247 28 sepsis sepsis NN cord-335975-m6lkrehi 4247 29 or or CC cord-335975-m6lkrehi 4247 30 septic septic JJ cord-335975-m6lkrehi 4247 31 shock shock NN cord-335975-m6lkrehi 4247 32 . . . cord-335975-m6lkrehi 4248 1 The the DT cord-335975-m6lkrehi 4248 2 mortality mortality NN cord-335975-m6lkrehi 4248 3 risk risk NN cord-335975-m6lkrehi 4248 4 is be VBZ cord-335975-m6lkrehi 4248 5 higher high JJR cord-335975-m6lkrehi 4248 6 . . . cord-335975-m6lkrehi 4249 1 The the DT cord-335975-m6lkrehi 4249 2 French french JJ cord-335975-m6lkrehi 4249 3 guidelines guideline NNS cord-335975-m6lkrehi 4249 4 published publish VBN cord-335975-m6lkrehi 4249 5 in in IN cord-335975-m6lkrehi 4249 6 2016 2016 CD cord-335975-m6lkrehi 4249 7 were be VBD cord-335975-m6lkrehi 4249 8 formulated formulate VBN cord-335975-m6lkrehi 4249 9 to to TO cord-335975-m6lkrehi 4249 10 homogenize homogenize VB cord-335975-m6lkrehi 4249 11 the the DT cord-335975-m6lkrehi 4249 12 clinical clinical JJ cord-335975-m6lkrehi 4249 13 practices practice NNS cord-335975-m6lkrehi 4249 14 and and CC cord-335975-m6lkrehi 4249 15 improve improve VB cord-335975-m6lkrehi 4249 16 survival survival NN cord-335975-m6lkrehi 4249 17 . . . cord-335975-m6lkrehi 4250 1 We -PRON- PRP cord-335975-m6lkrehi 4250 2 performed perform VBD cord-335975-m6lkrehi 4250 3 a a DT cord-335975-m6lkrehi 4250 4 monocentric monocentric JJ cord-335975-m6lkrehi 4250 5 retrospective retrospective JJ cord-335975-m6lkrehi 4250 6 study study NN cord-335975-m6lkrehi 4250 7 including include VBG cord-335975-m6lkrehi 4250 8 all all DT cord-335975-m6lkrehi 4250 9 consecutive consecutive JJ cord-335975-m6lkrehi 4250 10 patients patient NNS cord-335975-m6lkrehi 4250 11 admitted admit VBN cord-335975-m6lkrehi 4250 12 to to IN cord-335975-m6lkrehi 4250 13 the the DT cord-335975-m6lkrehi 4250 14 medical medical JJ cord-335975-m6lkrehi 4250 15 ICU ICU NNP cord-335975-m6lkrehi 4250 16 of of IN cord-335975-m6lkrehi 4250 17 a a DT cord-335975-m6lkrehi 4250 18 tertiary tertiary JJ cord-335975-m6lkrehi 4250 19 hospital hospital NN cord-335975-m6lkrehi 4250 20 to to IN cord-335975-m6lkrehi 4250 21 a a DT cord-335975-m6lkrehi 4250 22 neutropenia neutropenia NN cord-335975-m6lkrehi 4250 23 with with IN cord-335975-m6lkrehi 4250 24 sepsis sepsis NN cord-335975-m6lkrehi 4250 25 or or CC cord-335975-m6lkrehi 4250 26 septic septic JJ cord-335975-m6lkrehi 4250 27 shock shock NN cord-335975-m6lkrehi 4250 28 , , , cord-335975-m6lkrehi 4250 29 between between IN cord-335975-m6lkrehi 4250 30 the the DT cord-335975-m6lkrehi 4250 31 30th 30th NN cord-335975-m6lkrehi 4250 32 of of IN cord-335975-m6lkrehi 4250 33 December December NNP cord-335975-m6lkrehi 4250 34 2012 2012 CD cord-335975-m6lkrehi 4250 35 and and CC cord-335975-m6lkrehi 4250 36 the the DT cord-335975-m6lkrehi 4250 37 30th 30th NN cord-335975-m6lkrehi 4250 38 of of IN cord-335975-m6lkrehi 4250 39 December December NNP cord-335975-m6lkrehi 4250 40 2016 2016 CD cord-335975-m6lkrehi 4250 41 . . . cord-335975-m6lkrehi 4251 1 The the DT cord-335975-m6lkrehi 4251 2 study study NN cord-335975-m6lkrehi 4251 3 protocol protocol NN cord-335975-m6lkrehi 4251 4 was be VBD cord-335975-m6lkrehi 4251 5 approved approve VBN cord-335975-m6lkrehi 4251 6 by by IN cord-335975-m6lkrehi 4251 7 the the DT cord-335975-m6lkrehi 4251 8 local local JJ cord-335975-m6lkrehi 4251 9 Ethics Ethics NNP cord-335975-m6lkrehi 4251 10 Committee Committee NNP cord-335975-m6lkrehi 4251 11 ( ( -LRB- cord-335975-m6lkrehi 4251 12 2017 2017 CD cord-335975-m6lkrehi 4251 13 . . . cord-335975-m6lkrehi 4252 1 CE15 CE15 NNP cord-335975-m6lkrehi 4252 2 ) ) -RRB- cord-335975-m6lkrehi 4252 3 and and CC cord-335975-m6lkrehi 4252 4 published publish VBN cord-335975-m6lkrehi 4252 5 on on IN cord-335975-m6lkrehi 4252 6 clinical clinical JJ cord-335975-m6lkrehi 4252 7 trial trial NN cord-335975-m6lkrehi 4252 8 ( ( -LRB- cord-335975-m6lkrehi 4252 9 NCT03217721 NCT03217721 NNP cord-335975-m6lkrehi 4252 10 ) ) -RRB- cord-335975-m6lkrehi 4252 11 . . . cord-335975-m6lkrehi 4253 1 Results result NNS cord-335975-m6lkrehi 4253 2 : : : cord-335975-m6lkrehi 4254 1 2235 2235 CD cord-335975-m6lkrehi 4254 2 patients patient NNS cord-335975-m6lkrehi 4254 3 were be VBD cord-335975-m6lkrehi 4254 4 admitted admit VBN cord-335975-m6lkrehi 4254 5 in in IN cord-335975-m6lkrehi 4254 6 ICU ICU NNP cord-335975-m6lkrehi 4254 7 during during IN cord-335975-m6lkrehi 4254 8 this this DT cord-335975-m6lkrehi 4254 9 period period NN cord-335975-m6lkrehi 4254 10 . . . cord-335975-m6lkrehi 4255 1 130 130 CD cord-335975-m6lkrehi 4255 2 patients patient NNS cord-335975-m6lkrehi 4255 3 ( ( -LRB- cord-335975-m6lkrehi 4255 4 17 17 CD cord-335975-m6lkrehi 4255 5 % % NN cord-335975-m6lkrehi 4255 6 ) ) -RRB- cord-335975-m6lkrehi 4255 7 presented present VBD cord-335975-m6lkrehi 4255 8 a a DT cord-335975-m6lkrehi 4255 9 neutropenia neutropenia NN cord-335975-m6lkrehi 4255 10 with with IN cord-335975-m6lkrehi 4255 11 sepsis sepsis NN cord-335975-m6lkrehi 4255 12 or or CC cord-335975-m6lkrehi 4255 13 septic septic JJ cord-335975-m6lkrehi 4255 14 shock shock NN cord-335975-m6lkrehi 4255 15 . . . cord-335975-m6lkrehi 4256 1 Among among IN cord-335975-m6lkrehi 4256 2 these these DT cord-335975-m6lkrehi 4256 3 patients patient NNS cord-335975-m6lkrehi 4256 4 , , , cord-335975-m6lkrehi 4256 5 92 92 CD cord-335975-m6lkrehi 4256 6 % % NN cord-335975-m6lkrehi 4256 7 had have VBD cord-335975-m6lkrehi 4256 8 hematologic hematologic JJ cord-335975-m6lkrehi 4256 9 malignancies malignancy NNS cord-335975-m6lkrehi 4256 10 and and CC cord-335975-m6lkrehi 4256 11 5 5 CD cord-335975-m6lkrehi 4256 12 % % NN cord-335975-m6lkrehi 4256 13 had have VBD cord-335975-m6lkrehi 4256 14 solid solid JJ cord-335975-m6lkrehi 4256 15 tumour tumour NN cord-335975-m6lkrehi 4256 16 . . . cord-335975-m6lkrehi 4257 1 78 78 CD cord-335975-m6lkrehi 4257 2 patients patient NNS cord-335975-m6lkrehi 4257 3 ( ( -LRB- cord-335975-m6lkrehi 4257 4 60 60 CD cord-335975-m6lkrehi 4257 5 % % NN cord-335975-m6lkrehi 4257 6 ) ) -RRB- cord-335975-m6lkrehi 4257 7 was be VBD cord-335975-m6lkrehi 4257 8 treated treat VBN cord-335975-m6lkrehi 4257 9 empirically empirically RB cord-335975-m6lkrehi 4257 10 with with IN cord-335975-m6lkrehi 4257 11 antipseudomonal antipseudomonal JJ cord-335975-m6lkrehi 4257 12 beta beta NN cord-335975-m6lkrehi 4257 13 - - HYPH cord-335975-m6lkrehi 4257 14 lactam lactam NNS cord-335975-m6lkrehi 4257 15 or or CC cord-335975-m6lkrehi 4257 16 carbapenem carbapenem NNP cord-335975-m6lkrehi 4257 17 and and CC cord-335975-m6lkrehi 4257 18 aminoglycoside aminoglycoside NNP cord-335975-m6lkrehi 4257 19 . . . cord-335975-m6lkrehi 4258 1 129 129 CD cord-335975-m6lkrehi 4258 2 ( ( -LRB- cord-335975-m6lkrehi 4258 3 99 99 CD cord-335975-m6lkrehi 4258 4 % % NN cord-335975-m6lkrehi 4258 5 ) ) -RRB- cord-335975-m6lkrehi 4258 6 skin skin NN cord-335975-m6lkrehi 4258 7 or or CC cord-335975-m6lkrehi 4258 8 suspected suspect VBN cord-335975-m6lkrehi 4258 9 catheter catheter NN cord-335975-m6lkrehi 4258 10 - - HYPH cord-335975-m6lkrehi 4258 11 related relate VBN cord-335975-m6lkrehi 4258 12 infections infection NNS cord-335975-m6lkrehi 4258 13 were be VBD cord-335975-m6lkrehi 4258 14 treated treat VBN cord-335975-m6lkrehi 4258 15 with with IN cord-335975-m6lkrehi 4258 16 anti anti JJ cord-335975-m6lkrehi 4258 17 - - JJ cord-335975-m6lkrehi 4258 18 MRSA MRSA NNP cord-335975-m6lkrehi 4258 19 ( ( -LRB- cord-335975-m6lkrehi 4258 20 methicillin methicillin NN cord-335975-m6lkrehi 4258 21 - - HYPH cord-335975-m6lkrehi 4258 22 resistant resistant JJ cord-335975-m6lkrehi 4258 23 staphylococcus staphylococcus NN cord-335975-m6lkrehi 4258 24 aureus aureus NN cord-335975-m6lkrehi 4258 25 ) ) -RRB- cord-335975-m6lkrehi 4258 26 , , , cord-335975-m6lkrehi 4258 27 vancomycin vancomycin NN cord-335975-m6lkrehi 4258 28 or or CC cord-335975-m6lkrehi 4258 29 linezolid linezolid NN cord-335975-m6lkrehi 4258 30 . . . cord-335975-m6lkrehi 4259 1 Adequate adequate JJ cord-335975-m6lkrehi 4259 2 antibiotics antibiotic NNS cord-335975-m6lkrehi 4259 3 as as IN cord-335975-m6lkrehi 4259 4 described describe VBN cord-335975-m6lkrehi 4259 5 in in IN cord-335975-m6lkrehi 4259 6 guidelines guideline NNS cord-335975-m6lkrehi 4259 7 was be VBD cord-335975-m6lkrehi 4259 8 performed perform VBN cord-335975-m6lkrehi 4259 9 to to IN cord-335975-m6lkrehi 4259 10 76 76 CD cord-335975-m6lkrehi 4259 11 patients patient NNS cord-335975-m6lkrehi 4259 12 ( ( -LRB- cord-335975-m6lkrehi 4259 13 58 58 CD cord-335975-m6lkrehi 4259 14 % % NN cord-335975-m6lkrehi 4259 15 ) ) -RRB- cord-335975-m6lkrehi 4259 16 . . . cord-335975-m6lkrehi 4260 1 76 76 CD cord-335975-m6lkrehi 4260 2 patients patient NNS cord-335975-m6lkrehi 4260 3 ( ( -LRB- cord-335975-m6lkrehi 4260 4 58 58 CD cord-335975-m6lkrehi 4260 5 % % NN cord-335975-m6lkrehi 4260 6 ) ) -RRB- cord-335975-m6lkrehi 4260 7 received receive VBN cord-335975-m6lkrehi 4260 8 aminoglycoside aminoglycoside NNP cord-335975-m6lkrehi 4260 9 ( ( -LRB- cord-335975-m6lkrehi 4260 10 58 58 CD cord-335975-m6lkrehi 4260 11 patients patient NNS cord-335975-m6lkrehi 4260 12 received receive VBD cord-335975-m6lkrehi 4260 13 initial initial JJ cord-335975-m6lkrehi 4260 14 dose dose NN cord-335975-m6lkrehi 4260 15 in in IN cord-335975-m6lkrehi 4260 16 ICU ICU NNP cord-335975-m6lkrehi 4260 17 , , , cord-335975-m6lkrehi 4260 18 18 18 CD cord-335975-m6lkrehi 4260 19 patients patient NNS cord-335975-m6lkrehi 4260 20 complement complement VBP cord-335975-m6lkrehi 4260 21 dose dose NN cord-335975-m6lkrehi 4260 22 ) ) -RRB- cord-335975-m6lkrehi 4260 23 and and CC cord-335975-m6lkrehi 4260 24 100 100 CD cord-335975-m6lkrehi 4260 25 ( ( -LRB- cord-335975-m6lkrehi 4260 26 77 77 CD cord-335975-m6lkrehi 4260 27 % % NN cord-335975-m6lkrehi 4260 28 ) ) -RRB- cord-335975-m6lkrehi 4260 29 received receive VBD cord-335975-m6lkrehi 4260 30 anti anti JJ cord-335975-m6lkrehi 4260 31 - - JJ cord-335975-m6lkrehi 4260 32 MRSA MRSA NNP cord-335975-m6lkrehi 4260 33 with with IN cord-335975-m6lkrehi 4260 34 antipseudomonal antipseudomonal JJ cord-335975-m6lkrehi 4260 35 betalactam betalactam NNP cord-335975-m6lkrehi 4260 36 or or CC cord-335975-m6lkrehi 4260 37 cabapenem cabapenem NNP cord-335975-m6lkrehi 4260 38 . . . cord-335975-m6lkrehi 4261 1 71 71 CD cord-335975-m6lkrehi 4261 2 patients patient NNS cord-335975-m6lkrehi 4261 3 ( ( -LRB- cord-335975-m6lkrehi 4261 4 55 55 CD cord-335975-m6lkrehi 4261 5 % % NN cord-335975-m6lkrehi 4261 6 ) ) -RRB- cord-335975-m6lkrehi 4261 7 had have VBD cord-335975-m6lkrehi 4261 8 microbiologically microbiologically RB cord-335975-m6lkrehi 4261 9 documented document VBN cord-335975-m6lkrehi 4261 10 infections infection NNS cord-335975-m6lkrehi 4261 11 with with IN cord-335975-m6lkrehi 4261 12 , , , cord-335975-m6lkrehi 4261 13 59 59 CD cord-335975-m6lkrehi 4261 14 % % NN cord-335975-m6lkrehi 4261 15 of of IN cord-335975-m6lkrehi 4261 16 bacteria bacteria NNS cord-335975-m6lkrehi 4261 17 ( ( -LRB- cord-335975-m6lkrehi 4261 18 16 16 CD cord-335975-m6lkrehi 4261 19 % % NN cord-335975-m6lkrehi 4261 20 of of IN cord-335975-m6lkrehi 4261 21 gram gram NN cord-335975-m6lkrehi 4261 22 - - HYPH cord-335975-m6lkrehi 4261 23 posit posit JJ cord-335975-m6lkrehi 4261 24 cocci coccus NNS cord-335975-m6lkrehi 4261 25 , , , cord-335975-m6lkrehi 4261 26 1 1 CD cord-335975-m6lkrehi 4261 27 % % NN cord-335975-m6lkrehi 4261 28 of of IN cord-335975-m6lkrehi 4261 29 gram gram NN cord-335975-m6lkrehi 4261 30 - - HYPH cord-335975-m6lkrehi 4261 31 negative negative JJ cord-335975-m6lkrehi 4261 32 cocci coccus NNS cord-335975-m6lkrehi 4261 33 , , , cord-335975-m6lkrehi 4261 34 39 39 CD cord-335975-m6lkrehi 4261 35 % % NN cord-335975-m6lkrehi 4261 36 of of IN cord-335975-m6lkrehi 4261 37 gram gram NN cord-335975-m6lkrehi 4261 38 - - HYPH cord-335975-m6lkrehi 4261 39 negative negative JJ cord-335975-m6lkrehi 4261 40 bacillus bacillus NN cord-335975-m6lkrehi 4261 41 ) ) -RRB- cord-335975-m6lkrehi 4261 42 , , , cord-335975-m6lkrehi 4261 43 8 8 CD cord-335975-m6lkrehi 4261 44 % % NN cord-335975-m6lkrehi 4261 45 of of IN cord-335975-m6lkrehi 4261 46 fungi fungus NNS cord-335975-m6lkrehi 4261 47 and and CC cord-335975-m6lkrehi 4261 48 3 3 CD cord-335975-m6lkrehi 4261 49 % % NN cord-335975-m6lkrehi 4261 50 of of IN cord-335975-m6lkrehi 4261 51 viral viral JJ cord-335975-m6lkrehi 4261 52 infection infection NN cord-335975-m6lkrehi 4261 53 ( ( -LRB- cord-335975-m6lkrehi 4261 54 Table Table NNP cord-335975-m6lkrehi 4261 55 3 3 CD cord-335975-m6lkrehi 4261 56 ) ) -RRB- cord-335975-m6lkrehi 4261 57 . . . cord-335975-m6lkrehi 4262 1 Among among IN cord-335975-m6lkrehi 4262 2 of of IN cord-335975-m6lkrehi 4262 3 them -PRON- PRP cord-335975-m6lkrehi 4262 4 , , , cord-335975-m6lkrehi 4262 5 10 10 CD cord-335975-m6lkrehi 4262 6 % % NN cord-335975-m6lkrehi 4262 7 ( ( -LRB- cord-335975-m6lkrehi 4262 8 13 13 CD cord-335975-m6lkrehi 4262 9 ) ) -RRB- cord-335975-m6lkrehi 4262 10 of of IN cord-335975-m6lkrehi 4262 11 ESBL ESBL NNP cord-335975-m6lkrehi 4262 12 , , , cord-335975-m6lkrehi 4262 13 2 2 CD cord-335975-m6lkrehi 4262 14 % % NN cord-335975-m6lkrehi 4262 15 ( ( -LRB- cord-335975-m6lkrehi 4262 16 2 2 CD cord-335975-m6lkrehi 4262 17 ) ) -RRB- cord-335975-m6lkrehi 4262 18 of of IN cord-335975-m6lkrehi 4262 19 MRSA MRSA NNP cord-335975-m6lkrehi 4262 20 and and CC cord-335975-m6lkrehi 4262 21 2 2 CD cord-335975-m6lkrehi 4262 22 % % NN cord-335975-m6lkrehi 4262 23 ( ( -LRB- cord-335975-m6lkrehi 4262 24 2 2 CD cord-335975-m6lkrehi 4262 25 ) ) -RRB- cord-335975-m6lkrehi 4262 26 of of IN cord-335975-m6lkrehi 4262 27 emerging emerge VBG cord-335975-m6lkrehi 4262 28 highly highly RB cord-335975-m6lkrehi 4262 29 resistant resistant JJ cord-335975-m6lkrehi 4262 30 bacteria bacteria NNS cord-335975-m6lkrehi 4262 31 ( ( -LRB- cord-335975-m6lkrehi 4262 32 BHRe BHRe NNS cord-335975-m6lkrehi 4262 33 ) ) -RRB- cord-335975-m6lkrehi 4262 34 . . . cord-335975-m6lkrehi 4263 1 The the DT cord-335975-m6lkrehi 4263 2 ICU ICU NNP cord-335975-m6lkrehi 4263 3 - - HYPH cord-335975-m6lkrehi 4263 4 mortality mortality NN cord-335975-m6lkrehi 4263 5 rate rate NN cord-335975-m6lkrehi 4263 6 was be VBD cord-335975-m6lkrehi 4263 7 29 29 CD cord-335975-m6lkrehi 4263 8 % % NN cord-335975-m6lkrehi 4263 9 ( ( -LRB- cord-335975-m6lkrehi 4263 10 37 37 CD cord-335975-m6lkrehi 4263 11 130 130 CD cord-335975-m6lkrehi 4263 12 ) ) -RRB- cord-335975-m6lkrehi 4263 13 with with IN cord-335975-m6lkrehi 4263 14 28 28 CD cord-335975-m6lkrehi 4263 15 % % NN cord-335975-m6lkrehi 4263 16 of of IN cord-335975-m6lkrehi 4263 17 28-day 28-day CD cord-335975-m6lkrehi 4263 18 mortality mortality NN cord-335975-m6lkrehi 4263 19 ( ( -LRB- cord-335975-m6lkrehi 4263 20 36 36 CD cord-335975-m6lkrehi 4263 21 130 130 CD cord-335975-m6lkrehi 4263 22 ) ) -RRB- cord-335975-m6lkrehi 4263 23 . . . cord-335975-m6lkrehi 4264 1 The the DT cord-335975-m6lkrehi 4264 2 curves curve NNS cord-335975-m6lkrehi 4264 3 of of IN cord-335975-m6lkrehi 4264 4 the the DT cord-335975-m6lkrehi 4264 5 cumulative cumulative JJ cord-335975-m6lkrehi 4264 6 incidence incidence NN cord-335975-m6lkrehi 4264 7 of of IN cord-335975-m6lkrehi 4264 8 death death NN cord-335975-m6lkrehi 4264 9 risk risk NN cord-335975-m6lkrehi 4264 10 between between IN cord-335975-m6lkrehi 4264 11 D0 d0 NN cord-335975-m6lkrehi 4264 12 and and CC cord-335975-m6lkrehi 4264 13 D28 D28 NNP cord-335975-m6lkrehi 4264 14 were be VBD cord-335975-m6lkrehi 4264 15 no no RB cord-335975-m6lkrehi 4264 16 different different JJ cord-335975-m6lkrehi 4264 17 according accord VBG cord-335975-m6lkrehi 4264 18 to to IN cord-335975-m6lkrehi 4264 19 adequate adequate JJ cord-335975-m6lkrehi 4264 20 empirical empirical JJ cord-335975-m6lkrehi 4264 21 antibiotic antibiotic JJ cord-335975-m6lkrehi 4264 22 treatment treatment NN cord-335975-m6lkrehi 4264 23 as as IN cord-335975-m6lkrehi 4264 24 like like IN cord-335975-m6lkrehi 4264 25 French french JJ cord-335975-m6lkrehi 4264 26 guidelines guideline NNS cord-335975-m6lkrehi 4265 1 ( ( -LRB- cord-335975-m6lkrehi 4265 2 Fig Fig NNP cord-335975-m6lkrehi 4265 3 1 1 CD cord-335975-m6lkrehi 4265 4 ) ) -RRB- cord-335975-m6lkrehi 4265 5 . . . cord-335975-m6lkrehi 4266 1 By by IN cord-335975-m6lkrehi 4266 2 multivariate multivariate JJ cord-335975-m6lkrehi 4266 3 analysis analysis NN cord-335975-m6lkrehi 4266 4 , , , cord-335975-m6lkrehi 4266 5 independent independent JJ cord-335975-m6lkrehi 4266 6 factors factor NNS cord-335975-m6lkrehi 4266 7 of of IN cord-335975-m6lkrehi 4266 8 adequate adequate JJ cord-335975-m6lkrehi 4266 9 antibiotic antibiotic JJ cord-335975-m6lkrehi 4266 10 treatment treatment NN cord-335975-m6lkrehi 4266 11 were be VBD cord-335975-m6lkrehi 4266 12 septic septic JJ cord-335975-m6lkrehi 4266 13 shock shock NN cord-335975-m6lkrehi 4266 14 ( ( -LRB- cord-335975-m6lkrehi 4266 15 OR or CC cord-335975-m6lkrehi 4266 16 , , , cord-335975-m6lkrehi 4266 17 0.38 0.38 CD cord-335975-m6lkrehi 4266 18 + + SYM cord-335975-m6lkrehi 4266 19 95 95 CD cord-335975-m6lkrehi 4266 20 % % NN cord-335975-m6lkrehi 4266 21 CI CI NNP cord-335975-m6lkrehi 4266 22 0.15 0.15 CD cord-335975-m6lkrehi 4266 23 - - HYPH cord-335975-m6lkrehi 4266 24 0.96 0.96 CD cord-335975-m6lkrehi 4266 25 ) ) -RRB- cord-335975-m6lkrehi 4266 26 and and CC cord-335975-m6lkrehi 4266 27 febrile febrile JJ cord-335975-m6lkrehi 4266 28 neutropenia neutropenia NN cord-335975-m6lkrehi 4267 1 > > XX cord-335975-m6lkrehi 4267 2 7 7 CD cord-335975-m6lkrehi 4267 3 days day NNS cord-335975-m6lkrehi 4267 4 ( ( -LRB- cord-335975-m6lkrehi 4267 5 OR or CC cord-335975-m6lkrehi 4267 6 , , , cord-335975-m6lkrehi 4268 1 0.42 0.42 CD cord-335975-m6lkrehi 4268 2 + + SYM cord-335975-m6lkrehi 4268 3 95 95 CD cord-335975-m6lkrehi 4268 4 % % NN cord-335975-m6lkrehi 4268 5 CI CI NNP cord-335975-m6lkrehi 4268 6 0.20 0.20 CD cord-335975-m6lkrehi 4268 7 - - HYPH cord-335975-m6lkrehi 4268 8 0.88 0.88 CD cord-335975-m6lkrehi 4268 9 ) ) -RRB- cord-335975-m6lkrehi 4268 10 at at IN cord-335975-m6lkrehi 4268 11 ICU ICU NNP cord-335975-m6lkrehi 4268 12 admission admission NN cord-335975-m6lkrehi 4268 13 . . . cord-335975-m6lkrehi 4269 1 Conclusion conclusion NN cord-335975-m6lkrehi 4269 2 : : : cord-335975-m6lkrehi 4270 1 According accord VBG cord-335975-m6lkrehi 4270 2 to to IN cord-335975-m6lkrehi 4270 3 the the DT cord-335975-m6lkrehi 4270 4 usual usual JJ cord-335975-m6lkrehi 4270 5 clinical clinical JJ cord-335975-m6lkrehi 4270 6 practice practice NN cord-335975-m6lkrehi 4270 7 , , , cord-335975-m6lkrehi 4270 8 septic septic JJ cord-335975-m6lkrehi 4270 9 neutropenic neutropenic JJ cord-335975-m6lkrehi 4270 10 patients patient NNS cord-335975-m6lkrehi 4270 11 was be VBD cord-335975-m6lkrehi 4270 12 already already RB cord-335975-m6lkrehi 4270 13 treated treat VBN cord-335975-m6lkrehi 4270 14 empirically empirically RB cord-335975-m6lkrehi 4270 15 by by IN cord-335975-m6lkrehi 4270 16 bitherapy bitherapy NNP cord-335975-m6lkrehi 4270 17 including include VBG cord-335975-m6lkrehi 4270 18 antipseudomonal antipseudomonal JJ cord-335975-m6lkrehi 4270 19 or or CC cord-335975-m6lkrehi 4270 20 anti anti JJ cord-335975-m6lkrehi 4270 21 - - JJ cord-335975-m6lkrehi 4270 22 MRSA MRSA NNP cord-335975-m6lkrehi 4270 23 if if IN cord-335975-m6lkrehi 4270 24 there there EX cord-335975-m6lkrehi 4270 25 is be VBZ cord-335975-m6lkrehi 4270 26 a a DT cord-335975-m6lkrehi 4270 27 skin skin NN cord-335975-m6lkrehi 4270 28 or or CC cord-335975-m6lkrehi 4270 29 suspected suspect VBN cord-335975-m6lkrehi 4270 30 catheter catheter NN cord-335975-m6lkrehi 4270 31 - - HYPH cord-335975-m6lkrehi 4270 32 related relate VBN cord-335975-m6lkrehi 4270 33 infection infection NN cord-335975-m6lkrehi 4270 34 . . . cord-335975-m6lkrehi 4271 1 Adjunction Adjunction NNP cord-335975-m6lkrehi 4271 2 of of IN cord-335975-m6lkrehi 4271 3 aminoglycoside aminoglycoside NN cord-335975-m6lkrehi 4271 4 in in IN cord-335975-m6lkrehi 4271 5 of of IN cord-335975-m6lkrehi 4271 6 the the DT cord-335975-m6lkrehi 4271 7 symptomatology symptomatology NN cord-335975-m6lkrehi 4271 8 in in IN cord-335975-m6lkrehi 4271 9 case case NN cord-335975-m6lkrehi 4271 10 of of IN cord-335975-m6lkrehi 4271 11 overdose overdose NN cord-335975-m6lkrehi 4271 12 , , , cord-335975-m6lkrehi 4271 13 make make VB cord-335975-m6lkrehi 4271 14 the the DT cord-335975-m6lkrehi 4271 15 diagnosis diagnosis NN cord-335975-m6lkrehi 4271 16 difficult difficult JJ cord-335975-m6lkrehi 4271 17 , , , cord-335975-m6lkrehi 4271 18 especially especially RB cord-335975-m6lkrehi 4271 19 since since IN cord-335975-m6lkrehi 4271 20 the the DT cord-335975-m6lkrehi 4271 21 drug drug NN cord-335975-m6lkrehi 4271 22 in in IN cord-335975-m6lkrehi 4271 23 question question NN cord-335975-m6lkrehi 4271 24 is be VBZ cord-335975-m6lkrehi 4271 25 often often RB cord-335975-m6lkrehi 4271 26 unspecified unspecified JJ cord-335975-m6lkrehi 4271 27 and and CC cord-335975-m6lkrehi 4271 28 the the DT cord-335975-m6lkrehi 4271 29 toxicological toxicological JJ cord-335975-m6lkrehi 4271 30 analysis analysis NN cord-335975-m6lkrehi 4271 31 is be VBZ cord-335975-m6lkrehi 4271 32 not not RB cord-335975-m6lkrehi 4271 33 exhaustive exhaustive JJ cord-335975-m6lkrehi 4271 34 . . . cord-335975-m6lkrehi 4272 1 Introduction introduction NN cord-335975-m6lkrehi 4272 2 : : : cord-335975-m6lkrehi 4273 1 Carbon carbon NN cord-335975-m6lkrehi 4273 2 monoxide monoxide NN cord-335975-m6lkrehi 4273 3 intoxication intoxication NN cord-335975-m6lkrehi 4273 4 is be VBZ cord-335975-m6lkrehi 4273 5 a a DT cord-335975-m6lkrehi 4273 6 public public JJ cord-335975-m6lkrehi 4273 7 health health NN cord-335975-m6lkrehi 4273 8 problem problem NN cord-335975-m6lkrehi 4273 9 in in IN cord-335975-m6lkrehi 4273 10 Tunisia Tunisia NNP cord-335975-m6lkrehi 4273 11 and and CC cord-335975-m6lkrehi 4273 12 around around IN cord-335975-m6lkrehi 4273 13 the the DT cord-335975-m6lkrehi 4273 14 world world NN cord-335975-m6lkrehi 4273 15 . . . cord-335975-m6lkrehi 4274 1 Currently currently RB cord-335975-m6lkrehi 4274 2 , , , cord-335975-m6lkrehi 4274 3 it -PRON- PRP cord-335975-m6lkrehi 4274 4 is be VBZ cord-335975-m6lkrehi 4274 5 unclear unclear JJ cord-335975-m6lkrehi 4274 6 the the DT cord-335975-m6lkrehi 4274 7 impact impact NN cord-335975-m6lkrehi 4274 8 of of IN cord-335975-m6lkrehi 4274 9 this this DT cord-335975-m6lkrehi 4274 10 type type NN cord-335975-m6lkrehi 4274 11 of of IN cord-335975-m6lkrehi 4274 12 poisoning poisoning NN cord-335975-m6lkrehi 4274 13 in in IN cord-335975-m6lkrehi 4274 14 our -PRON- PRP$ cord-335975-m6lkrehi 4274 15 country country NN cord-335975-m6lkrehi 4274 16 for for IN cord-335975-m6lkrehi 4274 17 lack lack NN cord-335975-m6lkrehi 4274 18 of of IN cord-335975-m6lkrehi 4274 19 declarations declaration NNS cord-335975-m6lkrehi 4274 20 . . . cord-335975-m6lkrehi 4275 1 We -PRON- PRP cord-335975-m6lkrehi 4275 2 propose propose VBP cord-335975-m6lkrehi 4275 3 in in IN cord-335975-m6lkrehi 4275 4 our -PRON- PRP$ cord-335975-m6lkrehi 4275 5 work work NN cord-335975-m6lkrehi 4275 6 to to TO cord-335975-m6lkrehi 4275 7 study study VB cord-335975-m6lkrehi 4275 8 the the DT cord-335975-m6lkrehi 4275 9 epidemiological epidemiological JJ cord-335975-m6lkrehi 4275 10 characteristics characteristic NNS cord-335975-m6lkrehi 4275 11 of of IN cord-335975-m6lkrehi 4275 12 fatal fatal JJ cord-335975-m6lkrehi 4275 13 carbon carbon NN cord-335975-m6lkrehi 4275 14 monoxide monoxide NN cord-335975-m6lkrehi 4275 15 intoxications intoxication NNS cord-335975-m6lkrehi 4275 16 collected collect VBN cord-335975-m6lkrehi 4275 17 in in IN cord-335975-m6lkrehi 4275 18 the the DT cord-335975-m6lkrehi 4275 19 forensic forensic JJ cord-335975-m6lkrehi 4275 20 Pathology Pathology NNP cord-335975-m6lkrehi 4275 21 department department NN cord-335975-m6lkrehi 4275 22 of of IN cord-335975-m6lkrehi 4275 23 the the DT cord-335975-m6lkrehi 4275 24 university university NN cord-335975-m6lkrehi 4275 25 hospital hospital NN cord-335975-m6lkrehi 4275 26 in in IN cord-335975-m6lkrehi 4275 27 Sfax Sfax NNP cord-335975-m6lkrehi 4275 28 , , , cord-335975-m6lkrehi 4275 29 Tunisia Tunisia NNP cord-335975-m6lkrehi 4275 30 , , , cord-335975-m6lkrehi 4275 31 to to TO cord-335975-m6lkrehi 4275 32 describe describe VB cord-335975-m6lkrehi 4275 33 the the DT cord-335975-m6lkrehi 4275 34 different different JJ cord-335975-m6lkrehi 4275 35 steps step NNS cord-335975-m6lkrehi 4275 36 used use VBN cord-335975-m6lkrehi 4275 37 in in IN cord-335975-m6lkrehi 4275 38 forensic forensic JJ cord-335975-m6lkrehi 4275 39 diagnosis diagnosis NN cord-335975-m6lkrehi 4275 40 of of IN cord-335975-m6lkrehi 4275 41 fatal fatal JJ cord-335975-m6lkrehi 4275 42 carbon carbon NN cord-335975-m6lkrehi 4275 43 monoxide monoxide NN cord-335975-m6lkrehi 4275 44 intoxication intoxication NN cord-335975-m6lkrehi 4275 45 and and CC cord-335975-m6lkrehi 4275 46 to to TO cord-335975-m6lkrehi 4275 47 propose propose VB cord-335975-m6lkrehi 4275 48 preventive preventive JJ cord-335975-m6lkrehi 4275 49 measures measure NNS cord-335975-m6lkrehi 4275 50 to to TO cord-335975-m6lkrehi 4275 51 reduce reduce VB cord-335975-m6lkrehi 4275 52 the the DT cord-335975-m6lkrehi 4275 53 rate rate NN cord-335975-m6lkrehi 4275 54 of of IN cord-335975-m6lkrehi 4275 55 these these DT cord-335975-m6lkrehi 4275 56 intoxications intoxication NNS cord-335975-m6lkrehi 4275 57 . . . cord-335975-m6lkrehi 4276 1 Patients patient NNS cord-335975-m6lkrehi 4276 2 and and CC cord-335975-m6lkrehi 4276 3 methods method NNS cord-335975-m6lkrehi 4276 4 : : : cord-335975-m6lkrehi 4276 5 It -PRON- PRP cord-335975-m6lkrehi 4276 6 is be VBZ cord-335975-m6lkrehi 4276 7 a a DT cord-335975-m6lkrehi 4276 8 retrospective retrospective JJ cord-335975-m6lkrehi 4276 9 study study NN cord-335975-m6lkrehi 4276 10 of of IN cord-335975-m6lkrehi 4276 11 29 29 CD cord-335975-m6lkrehi 4276 12 cases case NNS cord-335975-m6lkrehi 4276 13 of of IN cord-335975-m6lkrehi 4276 14 fatal fatal JJ cord-335975-m6lkrehi 4276 15 carbon carbon NN cord-335975-m6lkrehi 4276 16 monoxide monoxide NN cord-335975-m6lkrehi 4276 17 intoxications intoxication NNS cord-335975-m6lkrehi 4276 18 collected collect VBN cord-335975-m6lkrehi 4276 19 in in IN cord-335975-m6lkrehi 4276 20 the the DT cord-335975-m6lkrehi 4276 21 Forensic Forensic NNP cord-335975-m6lkrehi 4276 22 Pathology Pathology NNP cord-335975-m6lkrehi 4276 23 Department Department NNP cord-335975-m6lkrehi 4276 24 of of IN cord-335975-m6lkrehi 4276 25 the the DT cord-335975-m6lkrehi 4276 26 University University NNP cord-335975-m6lkrehi 4276 27 Hospital Hospital NNP cord-335975-m6lkrehi 4276 28 in in IN cord-335975-m6lkrehi 4276 29 Sfax Sfax NNP cord-335975-m6lkrehi 4276 30 , , , cord-335975-m6lkrehi 4276 31 Tunisia Tunisia NNP cord-335975-m6lkrehi 4276 32 during during IN cord-335975-m6lkrehi 4276 33 06 06 CD cord-335975-m6lkrehi 4276 34 years year NNS cord-335975-m6lkrehi 4276 35 ( ( -LRB- cord-335975-m6lkrehi 4276 36 1 1 CD cord-335975-m6lkrehi 4276 37 January January NNP cord-335975-m6lkrehi 4276 38 2011 2011 CD cord-335975-m6lkrehi 4276 39 to to IN cord-335975-m6lkrehi 4276 40 31 31 CD cord-335975-m6lkrehi 4276 41 December December NNP cord-335975-m6lkrehi 4276 42 2016 2016 CD cord-335975-m6lkrehi 4276 43 ) ) -RRB- cord-335975-m6lkrehi 4276 44 . . . cord-335975-m6lkrehi 4277 1 Commemoratives commemorative NNS cord-335975-m6lkrehi 4277 2 were be VBD cord-335975-m6lkrehi 4277 3 collected collect VBN cord-335975-m6lkrehi 4277 4 from from IN cord-335975-m6lkrehi 4277 5 medical medical JJ cord-335975-m6lkrehi 4277 6 and and CC cord-335975-m6lkrehi 4277 7 police police NN cord-335975-m6lkrehi 4277 8 records record NNS cord-335975-m6lkrehi 4277 9 . . . cord-335975-m6lkrehi 4278 1 A a DT cord-335975-m6lkrehi 4278 2 forensic forensic JJ cord-335975-m6lkrehi 4278 3 autopsy autopsy NN cord-335975-m6lkrehi 4278 4 and and CC cord-335975-m6lkrehi 4278 5 a a DT cord-335975-m6lkrehi 4278 6 toxicological toxicological JJ cord-335975-m6lkrehi 4278 7 analysis analysis NN cord-335975-m6lkrehi 4278 8 were be VBD cord-335975-m6lkrehi 4278 9 carried carry VBN cord-335975-m6lkrehi 4278 10 out out RP cord-335975-m6lkrehi 4278 11 in in IN cord-335975-m6lkrehi 4278 12 all all DT cord-335975-m6lkrehi 4278 13 cases case NNS cord-335975-m6lkrehi 4278 14 . . . cord-335975-m6lkrehi 4279 1 Results result NNS cord-335975-m6lkrehi 4279 2 : : : cord-335975-m6lkrehi 4280 1 Fatal fatal JJ cord-335975-m6lkrehi 4280 2 carbon carbon NN cord-335975-m6lkrehi 4280 3 monoxide monoxide NN cord-335975-m6lkrehi 4280 4 intoxication intoxication NN cord-335975-m6lkrehi 4280 5 is be VBZ cord-335975-m6lkrehi 4280 6 the the DT cord-335975-m6lkrehi 4280 7 leading leading JJ cord-335975-m6lkrehi 4280 8 cause cause NN cord-335975-m6lkrehi 4280 9 of of IN cord-335975-m6lkrehi 4280 10 toxic toxic JJ cord-335975-m6lkrehi 4280 11 death death NN cord-335975-m6lkrehi 4280 12 in in IN cord-335975-m6lkrehi 4280 13 Sfax Sfax NNP cord-335975-m6lkrehi 4280 14 during during IN cord-335975-m6lkrehi 4280 15 the the DT cord-335975-m6lkrehi 4280 16 period period NN cord-335975-m6lkrehi 4280 17 of of IN cord-335975-m6lkrehi 4280 18 our -PRON- PRP$ cord-335975-m6lkrehi 4280 19 study study NN cord-335975-m6lkrehi 4280 20 . . . cord-335975-m6lkrehi 4281 1 We -PRON- PRP cord-335975-m6lkrehi 4281 2 notice notice VBP cord-335975-m6lkrehi 4281 3 a a DT cord-335975-m6lkrehi 4281 4 decrease decrease NN cord-335975-m6lkrehi 4281 5 in in IN cord-335975-m6lkrehi 4281 6 the the DT cord-335975-m6lkrehi 4281 7 incidence incidence NN cord-335975-m6lkrehi 4281 8 of of IN cord-335975-m6lkrehi 4281 9 this this DT cord-335975-m6lkrehi 4281 10 type type NN cord-335975-m6lkrehi 4281 11 of of IN cord-335975-m6lkrehi 4281 12 intoxication intoxication NN cord-335975-m6lkrehi 4281 13 . . . cord-335975-m6lkrehi 4282 1 The the DT cord-335975-m6lkrehi 4282 2 average average JJ cord-335975-m6lkrehi 4282 3 age age NN cord-335975-m6lkrehi 4282 4 of of IN cord-335975-m6lkrehi 4282 5 deaths death NNS cord-335975-m6lkrehi 4282 6 was be VBD cord-335975-m6lkrehi 4282 7 36 36 CD cord-335975-m6lkrehi 4282 8 years year NNS cord-335975-m6lkrehi 4282 9 and and CC cord-335975-m6lkrehi 4282 10 2 2 CD cord-335975-m6lkrehi 4282 11 months month NNS cord-335975-m6lkrehi 4282 12 with with IN cord-335975-m6lkrehi 4282 13 male male JJ cord-335975-m6lkrehi 4282 14 predominance predominance NN cord-335975-m6lkrehi 4282 15 . . . cord-335975-m6lkrehi 4283 1 The the DT cord-335975-m6lkrehi 4283 2 peak peak NN cord-335975-m6lkrehi 4283 3 frequency frequency NN cord-335975-m6lkrehi 4283 4 of of IN cord-335975-m6lkrehi 4283 5 intoxication intoxication NN cord-335975-m6lkrehi 4283 6 was be VBD cord-335975-m6lkrehi 4283 7 in in IN cord-335975-m6lkrehi 4283 8 cold cold JJ cord-335975-m6lkrehi 4283 9 season season NN cord-335975-m6lkrehi 4283 10 . . . cord-335975-m6lkrehi 4284 1 The the DT cord-335975-m6lkrehi 4284 2 most most RBS cord-335975-m6lkrehi 4284 3 frequent frequent JJ cord-335975-m6lkrehi 4284 4 form form NN cord-335975-m6lkrehi 4284 5 of of IN cord-335975-m6lkrehi 4284 6 intoxication intoxication NN cord-335975-m6lkrehi 4284 7 was be VBD cord-335975-m6lkrehi 4284 8 accidental accidental JJ cord-335975-m6lkrehi 4284 9 . . . cord-335975-m6lkrehi 4285 1 The the DT cord-335975-m6lkrehi 4285 2 source source NN cord-335975-m6lkrehi 4285 3 of of IN cord-335975-m6lkrehi 4285 4 carbon carbon NN cord-335975-m6lkrehi 4285 5 monoxide monoxide NN cord-335975-m6lkrehi 4285 6 was be VBD cord-335975-m6lkrehi 4285 7 mainly mainly RB cord-335975-m6lkrehi 4285 8 the the DT cord-335975-m6lkrehi 4285 9 defective defective JJ cord-335975-m6lkrehi 4285 10 water water NN cord-335975-m6lkrehi 4285 11 heater heater NN cord-335975-m6lkrehi 4285 12 often often RB cord-335975-m6lkrehi 4285 13 placed place VBD cord-335975-m6lkrehi 4285 14 in in IN cord-335975-m6lkrehi 4285 15 poorly poorly RB cord-335975-m6lkrehi 4285 16 ventilated ventilate VBN cord-335975-m6lkrehi 4285 17 areas area NNS cord-335975-m6lkrehi 4285 18 . . . cord-335975-m6lkrehi 4286 1 The the DT cord-335975-m6lkrehi 4286 2 classic classic JJ cord-335975-m6lkrehi 4286 3 carmine carmine JJ cord-335975-m6lkrehi 4286 4 red red JJ cord-335975-m6lkrehi 4286 5 - - HYPH cord-335975-m6lkrehi 4286 6 color color NN cord-335975-m6lkrehi 4286 7 of of IN cord-335975-m6lkrehi 4286 8 lividity lividity NN cord-335975-m6lkrehi 4286 9 was be VBD cord-335975-m6lkrehi 4286 10 found find VBN cord-335975-m6lkrehi 4286 11 in in IN cord-335975-m6lkrehi 4286 12 the the DT cord-335975-m6lkrehi 4286 13 majority majority NN cord-335975-m6lkrehi 4286 14 of of IN cord-335975-m6lkrehi 4286 15 cases case NNS cord-335975-m6lkrehi 4286 16 . . . cord-335975-m6lkrehi 4287 1 Myocardial myocardial JJ cord-335975-m6lkrehi 4287 2 distress distress NN cord-335975-m6lkrehi 4287 3 , , , cord-335975-m6lkrehi 4287 4 favored favor VBN cord-335975-m6lkrehi 4287 5 by by IN cord-335975-m6lkrehi 4287 6 hypoxia hypoxia NN cord-335975-m6lkrehi 4287 7 , , , cord-335975-m6lkrehi 4287 8 has have VBZ cord-335975-m6lkrehi 4287 9 been be VBN cord-335975-m6lkrehi 4287 10 reported report VBN cord-335975-m6lkrehi 4287 11 in in IN cord-335975-m6lkrehi 4287 12 two two CD cord-335975-m6lkrehi 4287 13 subjects subject NNS cord-335975-m6lkrehi 4287 14 with with IN cord-335975-m6lkrehi 4287 15 a a DT cord-335975-m6lkrehi 4287 16 pathological pathological JJ cord-335975-m6lkrehi 4287 17 coronary coronary JJ cord-335975-m6lkrehi 4287 18 artery artery NN cord-335975-m6lkrehi 4287 19 . . . cord-335975-m6lkrehi 4288 1 The the DT cord-335975-m6lkrehi 4288 2 mean mean JJ cord-335975-m6lkrehi 4288 3 HbCO hbco NN cord-335975-m6lkrehi 4288 4 level level NN cord-335975-m6lkrehi 4288 5 was be VBD cord-335975-m6lkrehi 4288 6 51.59 51.59 CD cord-335975-m6lkrehi 4288 7 % % NN cord-335975-m6lkrehi 4288 8 . . . cord-335975-m6lkrehi 4289 1 However however RB cord-335975-m6lkrehi 4289 2 , , , cord-335975-m6lkrehi 4289 3 account account NN cord-335975-m6lkrehi 4289 4 must must MD cord-335975-m6lkrehi 4289 5 be be VB cord-335975-m6lkrehi 4289 6 taken take VBN cord-335975-m6lkrehi 4289 7 of of IN cord-335975-m6lkrehi 4289 8 the the DT cord-335975-m6lkrehi 4289 9 survival survival NN cord-335975-m6lkrehi 4289 10 time time NN cord-335975-m6lkrehi 4289 11 and and CC cord-335975-m6lkrehi 4289 12 the the DT cord-335975-m6lkrehi 4289 13 time time NN cord-335975-m6lkrehi 4289 14 elapsed elapse VBN cord-335975-m6lkrehi 4289 15 between between IN cord-335975-m6lkrehi 4289 16 death death NN cord-335975-m6lkrehi 4289 17 and and CC cord-335975-m6lkrehi 4289 18 dosing dosing NN cord-335975-m6lkrehi 4289 19 of of IN cord-335975-m6lkrehi 4289 20 HbCO HbCO NNP cord-335975-m6lkrehi 4289 21 . . . cord-335975-m6lkrehi 4290 1 The the DT cord-335975-m6lkrehi 4290 2 incidence incidence NN cord-335975-m6lkrehi 4290 3 of of IN cord-335975-m6lkrehi 4290 4 fatal fatal JJ cord-335975-m6lkrehi 4290 5 carbon carbon NN cord-335975-m6lkrehi 4290 6 monoxide monoxide NN cord-335975-m6lkrehi 4290 7 intoxication intoxication NN cord-335975-m6lkrehi 4290 8 has have VBZ cord-335975-m6lkrehi 4290 9 decreased decrease VBN cord-335975-m6lkrehi 4290 10 since since IN cord-335975-m6lkrehi 4290 11 2011 2011 CD cord-335975-m6lkrehi 4290 12 and and CC cord-335975-m6lkrehi 4290 13 the the DT cord-335975-m6lkrehi 4290 14 victim victim NN cord-335975-m6lkrehi 4290 15 profile profile NN cord-335975-m6lkrehi 4290 16 has have VBZ cord-335975-m6lkrehi 4290 17 not not RB cord-335975-m6lkrehi 4290 18 changed change VBN cord-335975-m6lkrehi 4290 19 too too RB cord-335975-m6lkrehi 4290 20 much much RB cord-335975-m6lkrehi 4290 21 . . . cord-335975-m6lkrehi 4291 1 The the DT cord-335975-m6lkrehi 4291 2 fatal fatal JJ cord-335975-m6lkrehi 4291 3 carbon carbon NN cord-335975-m6lkrehi 4291 4 monoxide monoxide NN cord-335975-m6lkrehi 4291 5 intoxication intoxication NN cord-335975-m6lkrehi 4291 6 is be VBZ cord-335975-m6lkrehi 4291 7 still still RB cord-335975-m6lkrehi 4291 8 persists persist VBZ cord-335975-m6lkrehi 4291 9 as as IN cord-335975-m6lkrehi 4291 10 a a DT cord-335975-m6lkrehi 4291 11 public public JJ cord-335975-m6lkrehi 4291 12 health health NN cord-335975-m6lkrehi 4291 13 problem problem NN cord-335975-m6lkrehi 4291 14 in in IN cord-335975-m6lkrehi 4291 15 Tunisia Tunisia NNP cord-335975-m6lkrehi 4291 16 . . . cord-335975-m6lkrehi 4292 1 The the DT cord-335975-m6lkrehi 4292 2 reduction reduction NN cord-335975-m6lkrehi 4292 3 of of IN cord-335975-m6lkrehi 4292 4 its -PRON- PRP$ cord-335975-m6lkrehi 4292 5 frequency frequency NN cord-335975-m6lkrehi 4292 6 requires require VBZ cord-335975-m6lkrehi 4292 7 the the DT cord-335975-m6lkrehi 4292 8 implementation implementation NN cord-335975-m6lkrehi 4292 9 of of IN cord-335975-m6lkrehi 4292 10 a a DT cord-335975-m6lkrehi 4292 11 well well RB cord-335975-m6lkrehi 4292 12 - - HYPH cord-335975-m6lkrehi 4292 13 structured structure VBN cord-335975-m6lkrehi 4292 14 prevention prevention NN cord-335975-m6lkrehi 4292 15 plan plan NN cord-335975-m6lkrehi 4292 16 based base VBN cord-335975-m6lkrehi 4292 17 on on IN cord-335975-m6lkrehi 4292 18 epidemiological epidemiological JJ cord-335975-m6lkrehi 4292 19 data datum NNS cord-335975-m6lkrehi 4292 20 from from IN cord-335975-m6lkrehi 4292 21 a a DT cord-335975-m6lkrehi 4292 22 national national JJ cord-335975-m6lkrehi 4292 23 registry registry NN cord-335975-m6lkrehi 4292 24 . . . cord-335975-m6lkrehi 4293 1 The the DT cord-335975-m6lkrehi 4293 2 identification identification NN cord-335975-m6lkrehi 4293 3 of of IN cord-335975-m6lkrehi 4293 4 these these DT cord-335975-m6lkrehi 4293 5 data datum NNS cord-335975-m6lkrehi 4293 6 requires require VBZ cord-335975-m6lkrehi 4293 7 mandatory mandatory JJ cord-335975-m6lkrehi 4293 8 reporting reporting NN cord-335975-m6lkrehi 4293 9 of of IN cord-335975-m6lkrehi 4293 10 this this DT cord-335975-m6lkrehi 4293 11 type type NN cord-335975-m6lkrehi 4293 12 of of IN cord-335975-m6lkrehi 4293 13 intoxication intoxication NN cord-335975-m6lkrehi 4293 14 in in IN cord-335975-m6lkrehi 4293 15 Tunisia Tunisia NNP cord-335975-m6lkrehi 4293 16 . . . cord-335975-m6lkrehi 4294 1 Introduction introduction NN cord-335975-m6lkrehi 4294 2 : : : cord-335975-m6lkrehi 4295 1 Olanzapine Olanzapine NNP cord-335975-m6lkrehi 4295 2 is be VBZ cord-335975-m6lkrehi 4295 3 an an DT cord-335975-m6lkrehi 4295 4 atypical atypical JJ cord-335975-m6lkrehi 4295 5 antipsychotic antipsychotic JJ cord-335975-m6lkrehi 4295 6 drug drug NN cord-335975-m6lkrehi 4295 7 frequently frequently RB cord-335975-m6lkrehi 4295 8 prescribed prescribe VBN cord-335975-m6lkrehi 4295 9 in in IN cord-335975-m6lkrehi 4295 10 the the DT cord-335975-m6lkrehi 4295 11 treatement treatement NN cord-335975-m6lkrehi 4295 12 of of IN cord-335975-m6lkrehi 4295 13 bipolar bipolar JJ cord-335975-m6lkrehi 4295 14 disorder disorder NN cord-335975-m6lkrehi 4295 15 and and CC cord-335975-m6lkrehi 4295 16 schizophrenia schizophrenia NN cord-335975-m6lkrehi 4295 17 . . . cord-335975-m6lkrehi 4296 1 Acute acute JJ cord-335975-m6lkrehi 4296 2 poisoning poisoning NN cord-335975-m6lkrehi 4296 3 with with IN cord-335975-m6lkrehi 4296 4 this this DT cord-335975-m6lkrehi 4296 5 molecule molecule NN cord-335975-m6lkrehi 4296 6 is be VBZ cord-335975-m6lkrehi 4296 7 rarely rarely RB cord-335975-m6lkrehi 4296 8 reported report VBN cord-335975-m6lkrehi 4296 9 . . . cord-335975-m6lkrehi 4297 1 Through through IN cord-335975-m6lkrehi 4297 2 this this DT cord-335975-m6lkrehi 4297 3 study study NN cord-335975-m6lkrehi 4297 4 we -PRON- PRP cord-335975-m6lkrehi 4297 5 aimed aim VBD cord-335975-m6lkrehi 4297 6 to to TO cord-335975-m6lkrehi 4297 7 evaluate evaluate VB cord-335975-m6lkrehi 4297 8 the the DT cord-335975-m6lkrehi 4297 9 incidence incidence NN cord-335975-m6lkrehi 4297 10 and and CC cord-335975-m6lkrehi 4297 11 describe describe VB cord-335975-m6lkrehi 4297 12 the the DT cord-335975-m6lkrehi 4297 13 different different JJ cord-335975-m6lkrehi 4297 14 clinical clinical JJ cord-335975-m6lkrehi 4297 15 features feature NNS cord-335975-m6lkrehi 4297 16 of of IN cord-335975-m6lkrehi 4297 17 acute acute JJ cord-335975-m6lkrehi 4297 18 olanzapine olanzapine JJ cord-335975-m6lkrehi 4297 19 poisoning poisoning NN cord-335975-m6lkrehi 4297 20 . . . cord-335975-m6lkrehi 4298 1 Patients patient NNS cord-335975-m6lkrehi 4298 2 and and CC cord-335975-m6lkrehi 4298 3 methods method NNS cord-335975-m6lkrehi 4298 4 : : : cord-335975-m6lkrehi 4298 5 Retrospective retrospective JJ cord-335975-m6lkrehi 4298 6 analysis analysis NN cord-335975-m6lkrehi 4298 7 of of IN cord-335975-m6lkrehi 4298 8 all all DT cord-335975-m6lkrehi 4298 9 cases case NNS cord-335975-m6lkrehi 4298 10 of of IN cord-335975-m6lkrehi 4298 11 olanzapine olanzapine JJ cord-335975-m6lkrehi 4298 12 intoxication intoxication NN cord-335975-m6lkrehi 4298 13 admitted admit VBN cord-335975-m6lkrehi 4298 14 in in IN cord-335975-m6lkrehi 4298 15 12-bed 12-bed CD cord-335975-m6lkrehi 4298 16 teaching teaching NN cord-335975-m6lkrehi 4298 17 ICU ICU NNP cord-335975-m6lkrehi 4298 18 between between IN cord-335975-m6lkrehi 4298 19 January January NNP cord-335975-m6lkrehi 4298 20 2013 2013 CD cord-335975-m6lkrehi 4298 21 and and CC cord-335975-m6lkrehi 4298 22 Decembre Decembre NNP cord-335975-m6lkrehi 4298 23 2017 2017 CD cord-335975-m6lkrehi 4298 24 . . . cord-335975-m6lkrehi 4299 1 Inclusion inclusion NN cord-335975-m6lkrehi 4299 2 criteria criterion NNS cord-335975-m6lkrehi 4299 3 were be VBD cord-335975-m6lkrehi 4299 4 patient patient JJ cord-335975-m6lkrehi 4299 5 age age NN cord-335975-m6lkrehi 4299 6 ≥ ≥ CD cord-335975-m6lkrehi 4300 1 14 14 CD cord-335975-m6lkrehi 4300 2 year year NN cord-335975-m6lkrehi 4300 3 , , , cord-335975-m6lkrehi 4300 4 acute acute JJ cord-335975-m6lkrehi 4300 5 olanzapine olanzapine JJ cord-335975-m6lkrehi 4300 6 intoxication intoxication NN cord-335975-m6lkrehi 4300 7 , , , cord-335975-m6lkrehi 4300 8 the the DT cord-335975-m6lkrehi 4300 9 intoxication intoxication NN cord-335975-m6lkrehi 4300 10 severity severity NN cord-335975-m6lkrehi 4300 11 was be VBD cord-335975-m6lkrehi 4300 12 assessed assess VBN cord-335975-m6lkrehi 4300 13 by by IN cord-335975-m6lkrehi 4300 14 the the DT cord-335975-m6lkrehi 4300 15 Poisoning Poisoning NNP cord-335975-m6lkrehi 4300 16 Severity severity NN cord-335975-m6lkrehi 4300 17 Score Score NNP cord-335975-m6lkrehi 4300 18 ( ( -LRB- cord-335975-m6lkrehi 4300 19 PSS PSS NNP cord-335975-m6lkrehi 4300 20 ) ) -RRB- cord-335975-m6lkrehi 4300 21 of of IN cord-335975-m6lkrehi 4300 22 the the DT cord-335975-m6lkrehi 4300 23 European European NNP cord-335975-m6lkrehi 4300 24 Association Association NNP cord-335975-m6lkrehi 4300 25 of of IN cord-335975-m6lkrehi 4300 26 Poison Poison NNP cord-335975-m6lkrehi 4300 27 Centres Centres NNPS cord-335975-m6lkrehi 4300 28 and and CC cord-335975-m6lkrehi 4300 29 Clinical Clinical NNP cord-335975-m6lkrehi 4300 30 Toxicologists Toxicologists NNPS cord-335975-m6lkrehi 4300 31 . . . cord-335975-m6lkrehi 4301 1 The the DT cord-335975-m6lkrehi 4301 2 evaluation evaluation NN cord-335975-m6lkrehi 4301 3 of of IN cord-335975-m6lkrehi 4301 4 electrocardiograms electrocardiogram NNS cord-335975-m6lkrehi 4301 5 was be VBD cord-335975-m6lkrehi 4301 6 performed perform VBN cord-335975-m6lkrehi 4301 7 in in IN cord-335975-m6lkrehi 4301 8 the the DT cord-335975-m6lkrehi 4301 9 first first JJ cord-335975-m6lkrehi 4301 10 day day NN cord-335975-m6lkrehi 4301 11 of of IN cord-335975-m6lkrehi 4301 12 hospitalization hospitalization NN cord-335975-m6lkrehi 4301 13 . . . cord-335975-m6lkrehi 4302 1 The the DT cord-335975-m6lkrehi 4302 2 durations duration NNS cord-335975-m6lkrehi 4302 3 of of IN cord-335975-m6lkrehi 4302 4 QRS QRS NNP cord-335975-m6lkrehi 4302 5 and and CC cord-335975-m6lkrehi 4302 6 QTc QTc NNP cord-335975-m6lkrehi 4302 7 was be VBD cord-335975-m6lkrehi 4302 8 measured measure VBN cord-335975-m6lkrehi 4302 9 and and CC cord-335975-m6lkrehi 4302 10 arrhythmias arrhythmia NNS cord-335975-m6lkrehi 4302 11 and and CC cord-335975-m6lkrehi 4302 12 conduction conduction NN cord-335975-m6lkrehi 4302 13 disorders disorder NNS cord-335975-m6lkrehi 4302 14 was be VBD cord-335975-m6lkrehi 4302 15 identified identify VBN cord-335975-m6lkrehi 4302 16 . . . cord-335975-m6lkrehi 4303 1 Results result NNS cord-335975-m6lkrehi 4303 2 : : : cord-335975-m6lkrehi 4303 3 24 24 CD cord-335975-m6lkrehi 4303 4 patients patient NNS cord-335975-m6lkrehi 4303 5 were be VBD cord-335975-m6lkrehi 4303 6 included include VBN cord-335975-m6lkrehi 4303 7 , , , cord-335975-m6lkrehi 4303 8 the the DT cord-335975-m6lkrehi 4303 9 mean mean JJ cord-335975-m6lkrehi 4303 10 age age NN cord-335975-m6lkrehi 4303 11 was be VBD cord-335975-m6lkrehi 4303 12 35 35 CD cord-335975-m6lkrehi 4303 13 ± ± CD cord-335975-m6lkrehi 4303 14 11 11 CD cord-335975-m6lkrehi 4303 15 years year NNS cord-335975-m6lkrehi 4303 16 . . . cord-335975-m6lkrehi 4304 1 They -PRON- PRP cord-335975-m6lkrehi 4304 2 were be VBD cord-335975-m6lkrehi 4304 3 11 11 CD cord-335975-m6lkrehi 4304 4 males male NNS cord-335975-m6lkrehi 4304 5 and and CC cord-335975-m6lkrehi 4304 6 13 13 CD cord-335975-m6lkrehi 4304 7 females female NNS cord-335975-m6lkrehi 4304 8 . . . cord-335975-m6lkrehi 4305 1 Long long JJ cord-335975-m6lkrehi 4305 2 term term NN cord-335975-m6lkrehi 4305 3 treatment treatment NN cord-335975-m6lkrehi 4305 4 with with IN cord-335975-m6lkrehi 4305 5 olanzapine olanzapine NNP cord-335975-m6lkrehi 4305 6 was be VBD cord-335975-m6lkrehi 4305 7 noted note VBN cord-335975-m6lkrehi 4305 8 in in IN cord-335975-m6lkrehi 4305 9 19 19 CD cord-335975-m6lkrehi 4305 10 patients patient NNS cord-335975-m6lkrehi 4305 11 ( ( -LRB- cord-335975-m6lkrehi 4305 12 79 79 CD cord-335975-m6lkrehi 4305 13 % % NN cord-335975-m6lkrehi 4305 14 ) ) -RRB- cord-335975-m6lkrehi 4305 15 who who WP cord-335975-m6lkrehi 4305 16 suffered suffer VBD cord-335975-m6lkrehi 4305 17 from from IN cord-335975-m6lkrehi 4305 18 psychiatic psychiatic JJ cord-335975-m6lkrehi 4305 19 desease desease NNP cord-335975-m6lkrehi 4305 20 . . . cord-335975-m6lkrehi 4306 1 The the DT cord-335975-m6lkrehi 4306 2 supposed suppose VBN cord-335975-m6lkrehi 4306 3 ingestion ingestion NN cord-335975-m6lkrehi 4306 4 dose dose NN cord-335975-m6lkrehi 4306 5 ranged range VBD cord-335975-m6lkrehi 4306 6 from from IN cord-335975-m6lkrehi 4306 7 25 25 CD cord-335975-m6lkrehi 4306 8 to to IN cord-335975-m6lkrehi 4306 9 600 600 CD cord-335975-m6lkrehi 4306 10 mg mg NN cord-335975-m6lkrehi 4306 11 . . . cord-335975-m6lkrehi 4307 1 The the DT cord-335975-m6lkrehi 4307 2 mean mean JJ cord-335975-m6lkrehi 4307 3 consulting consulting NN cord-335975-m6lkrehi 4307 4 time time NN cord-335975-m6lkrehi 4307 5 was be VBD cord-335975-m6lkrehi 4307 6 5 5 CD cord-335975-m6lkrehi 4307 7 ± ± NNP cord-335975-m6lkrehi 4307 8 4 4 CD cord-335975-m6lkrehi 4307 9 h h NN cord-335975-m6lkrehi 4307 10 after after IN cord-335975-m6lkrehi 4307 11 the the DT cord-335975-m6lkrehi 4307 12 ingestion ingestion NN cord-335975-m6lkrehi 4307 13 . . . cord-335975-m6lkrehi 4308 1 Olanzapine Olanzapine NNP cord-335975-m6lkrehi 4308 2 was be VBD cord-335975-m6lkrehi 4308 3 co co JJ cord-335975-m6lkrehi 4308 4 - - JJ cord-335975-m6lkrehi 4308 5 ingested ingest VBN cord-335975-m6lkrehi 4308 6 with with IN cord-335975-m6lkrehi 4308 7 others other NNS cord-335975-m6lkrehi 4308 8 drugs drug NNS cord-335975-m6lkrehi 4308 9 in in IN cord-335975-m6lkrehi 4308 10 16 16 CD cord-335975-m6lkrehi 4308 11 patients patient NNS cord-335975-m6lkrehi 4308 12 ( ( -LRB- cord-335975-m6lkrehi 4308 13 66 66 CD cord-335975-m6lkrehi 4308 14 % % NN cord-335975-m6lkrehi 4308 15 ) ) -RRB- cord-335975-m6lkrehi 4308 16 . . . cord-335975-m6lkrehi 4308 17 Co Co NNS cord-335975-m6lkrehi 4308 18 - - JJ cord-335975-m6lkrehi 4308 19 ingested ingest VBN cord-335975-m6lkrehi 4308 20 drugs drug NNS cord-335975-m6lkrehi 4308 21 were be VBD cord-335975-m6lkrehi 4308 22 - - : cord-335975-m6lkrehi 4308 23 benzodiazepine benzodiazepine NN cord-335975-m6lkrehi 4308 24 ( ( -LRB- cord-335975-m6lkrehi 4308 25 n n NN cord-335975-m6lkrehi 4308 26 = = SYM cord-335975-m6lkrehi 4308 27 5 5 CD cord-335975-m6lkrehi 4308 28 ) ) -RRB- cord-335975-m6lkrehi 4308 29 , , , cord-335975-m6lkrehi 4308 30 levomepromazine levomepromazine NNP cord-335975-m6lkrehi 4308 31 ( ( -LRB- cord-335975-m6lkrehi 4308 32 n n NN cord-335975-m6lkrehi 4308 33 = = SYM cord-335975-m6lkrehi 4308 34 5 5 CD cord-335975-m6lkrehi 4308 35 ) ) -RRB- cord-335975-m6lkrehi 4308 36 , , , cord-335975-m6lkrehi 4308 37 serotonin serotonin NN cord-335975-m6lkrehi 4308 38 recapture recapture NN cord-335975-m6lkrehi 4308 39 inhibitor inhibitor NN cord-335975-m6lkrehi 4308 40 ( ( -LRB- cord-335975-m6lkrehi 4308 41 n n NN cord-335975-m6lkrehi 4308 42 = = SYM cord-335975-m6lkrehi 4308 43 3 3 CD cord-335975-m6lkrehi 4308 44 ) ) -RRB- cord-335975-m6lkrehi 4308 45 , , , cord-335975-m6lkrehi 4308 46 amitriptilyne amitriptilyne NNP cord-335975-m6lkrehi 4308 47 ( ( -LRB- cord-335975-m6lkrehi 4308 48 n n NN cord-335975-m6lkrehi 4308 49 = = SYM cord-335975-m6lkrehi 4308 50 2 2 CD cord-335975-m6lkrehi 4308 51 ) ) -RRB- cord-335975-m6lkrehi 4308 52 and and CC cord-335975-m6lkrehi 4308 53 biperiden biperiden NNP cord-335975-m6lkrehi 4308 54 ( ( -LRB- cord-335975-m6lkrehi 4308 55 n n NN cord-335975-m6lkrehi 4308 56 = = SYM cord-335975-m6lkrehi 4308 57 1 1 CD cord-335975-m6lkrehi 4308 58 ) ) -RRB- cord-335975-m6lkrehi 4308 59 . . . cord-335975-m6lkrehi 4309 1 The the DT cord-335975-m6lkrehi 4309 2 PSS PSS NNP cord-335975-m6lkrehi 4309 3 was be VBD cord-335975-m6lkrehi 4309 4 moderate moderate JJ cord-335975-m6lkrehi 4309 5 in in IN cord-335975-m6lkrehi 4309 6 9 9 CD cord-335975-m6lkrehi 4309 7 cases case NNS cord-335975-m6lkrehi 4309 8 ( ( -LRB- cord-335975-m6lkrehi 4309 9 37.5 37.5 CD cord-335975-m6lkrehi 4309 10 % % NN cord-335975-m6lkrehi 4309 11 ) ) -RRB- cord-335975-m6lkrehi 4309 12 , , , cord-335975-m6lkrehi 4309 13 severe severe JJ cord-335975-m6lkrehi 4309 14 in in IN cord-335975-m6lkrehi 4309 15 14 14 CD cord-335975-m6lkrehi 4309 16 cases case NNS cord-335975-m6lkrehi 4309 17 ( ( -LRB- cord-335975-m6lkrehi 4309 18 58 58 CD cord-335975-m6lkrehi 4309 19 % % NN cord-335975-m6lkrehi 4309 20 ) ) -RRB- cord-335975-m6lkrehi 4309 21 and and CC cord-335975-m6lkrehi 4309 22 fatal fatal JJ cord-335975-m6lkrehi 4309 23 in in IN cord-335975-m6lkrehi 4309 24 1 1 CD cord-335975-m6lkrehi 4309 25 case case NN cord-335975-m6lkrehi 4309 26 . . . cord-335975-m6lkrehi 4310 1 The the DT cord-335975-m6lkrehi 4310 2 main main JJ cord-335975-m6lkrehi 4310 3 clinical clinical JJ cord-335975-m6lkrehi 4310 4 signs sign NNS cord-335975-m6lkrehi 4310 5 were be VBD cord-335975-m6lkrehi 4310 6 tachycardia tachycardia JJ cord-335975-m6lkrehi 4310 7 and and CC cord-335975-m6lkrehi 4310 8 miosis miosis NN cord-335975-m6lkrehi 4310 9 in in IN cord-335975-m6lkrehi 4310 10 62 62 CD cord-335975-m6lkrehi 4310 11 % % NN cord-335975-m6lkrehi 4310 12 of of IN cord-335975-m6lkrehi 4310 13 cases case NNS cord-335975-m6lkrehi 4310 14 each each DT cord-335975-m6lkrehi 4310 15 of of IN cord-335975-m6lkrehi 4310 16 them -PRON- PRP cord-335975-m6lkrehi 4310 17 ( ( -LRB- cord-335975-m6lkrehi 4310 18 n n NN cord-335975-m6lkrehi 4310 19 = = SYM cord-335975-m6lkrehi 4310 20 15 15 CD cord-335975-m6lkrehi 4310 21 ) ) -RRB- cord-335975-m6lkrehi 4310 22 , , , cord-335975-m6lkrehi 4310 23 agitation agitation NN cord-335975-m6lkrehi 4310 24 in in IN cord-335975-m6lkrehi 4310 25 33 33 CD cord-335975-m6lkrehi 4310 26 % % NN cord-335975-m6lkrehi 4310 27 of of IN cord-335975-m6lkrehi 4310 28 cases case NNS cord-335975-m6lkrehi 4310 29 ( ( -LRB- cord-335975-m6lkrehi 4310 30 n n NN cord-335975-m6lkrehi 4310 31 = = SYM cord-335975-m6lkrehi 4310 32 8) 8) NN cord-335975-m6lkrehi 4310 33 . . . cord-335975-m6lkrehi 4311 1 ECG ECG NNP cord-335975-m6lkrehi 4311 2 abnormalities abnormality NNS cord-335975-m6lkrehi 4311 3 has have VBZ cord-335975-m6lkrehi 4311 4 been be VBN cord-335975-m6lkrehi 4311 5 detected detect VBN cord-335975-m6lkrehi 4311 6 such such JJ cord-335975-m6lkrehi 4311 7 as as IN cord-335975-m6lkrehi 4311 8 prolonged prolong VBN cord-335975-m6lkrehi 4311 9 QTc qtc NN cord-335975-m6lkrehi 4311 10 in in IN cord-335975-m6lkrehi 4311 11 5 5 CD cord-335975-m6lkrehi 4311 12 cases case NNS cord-335975-m6lkrehi 4311 13 with with IN cord-335975-m6lkrehi 4311 14 a a DT cord-335975-m6lkrehi 4311 15 mean mean JJ cord-335975-m6lkrehi 4311 16 duration duration NN cord-335975-m6lkrehi 4311 17 of of IN cord-335975-m6lkrehi 4311 18 460 460 CD cord-335975-m6lkrehi 4311 19 ± ± XX cord-335975-m6lkrehi 4312 1 28 28 CD cord-335975-m6lkrehi 4312 2 ms ms NNP cord-335975-m6lkrehi 4312 3 . . . cord-335975-m6lkrehi 4313 1 In in IN cord-335975-m6lkrehi 4313 2 the the DT cord-335975-m6lkrehi 4313 3 group group NN cord-335975-m6lkrehi 4313 4 of of IN cord-335975-m6lkrehi 4313 5 monointoxication monointoxication NN cord-335975-m6lkrehi 4313 6 ( ( -LRB- cord-335975-m6lkrehi 4313 7 8 8 CD cord-335975-m6lkrehi 4313 8 patients patient NNS cord-335975-m6lkrehi 4313 9 ) ) -RRB- cord-335975-m6lkrehi 4314 1 the the DT cord-335975-m6lkrehi 4314 2 PSS PSS NNP cord-335975-m6lkrehi 4314 3 was be VBD cord-335975-m6lkrehi 4314 4 moderate moderate JJ cord-335975-m6lkrehi 4314 5 in in IN cord-335975-m6lkrehi 4314 6 3 3 CD cord-335975-m6lkrehi 4314 7 cases case NNS cord-335975-m6lkrehi 4314 8 ( ( -LRB- cord-335975-m6lkrehi 4314 9 37.5 37.5 CD cord-335975-m6lkrehi 4314 10 % % NN cord-335975-m6lkrehi 4314 11 ) ) -RRB- cord-335975-m6lkrehi 4314 12 , , , cord-335975-m6lkrehi 4314 13 severe severe JJ cord-335975-m6lkrehi 4314 14 in in IN cord-335975-m6lkrehi 4314 15 4 4 CD cord-335975-m6lkrehi 4314 16 cases case NNS cord-335975-m6lkrehi 4314 17 ( ( -LRB- cord-335975-m6lkrehi 4314 18 50 50 CD cord-335975-m6lkrehi 4314 19 % % NN cord-335975-m6lkrehi 4314 20 ) ) -RRB- cord-335975-m6lkrehi 4314 21 and and CC cord-335975-m6lkrehi 4314 22 fatal fatal JJ cord-335975-m6lkrehi 4314 23 in in IN cord-335975-m6lkrehi 4314 24 one one CD cord-335975-m6lkrehi 4314 25 case case NN cord-335975-m6lkrehi 4314 26 . . . cord-335975-m6lkrehi 4315 1 The the DT cord-335975-m6lkrehi 4315 2 Coma Coma NNP cord-335975-m6lkrehi 4315 3 Glosgow Glosgow NNP cord-335975-m6lkrehi 4315 4 Scale scale NN cord-335975-m6lkrehi 4315 5 was be VBD cord-335975-m6lkrehi 4315 6 < < NNP cord-335975-m6lkrehi 4315 7 12 12 CD cord-335975-m6lkrehi 4315 8 Fig Fig NNP cord-335975-m6lkrehi 4315 9 . . . cord-335975-m6lkrehi 4316 1 1 1 LS cord-335975-m6lkrehi 4317 1 Kaplan Kaplan NNP cord-335975-m6lkrehi 4317 2 - - HYPH cord-335975-m6lkrehi 4317 3 Meier Meier NNP cord-335975-m6lkrehi 4317 4 survival survival NN cord-335975-m6lkrehi 4317 5 between between IN cord-335975-m6lkrehi 4317 6 admission admission NN cord-335975-m6lkrehi 4317 7 and and CC cord-335975-m6lkrehi 4317 8 28-day 28-day CD cord-335975-m6lkrehi 4317 9 according accord VBG cord-335975-m6lkrehi 4317 10 to to IN cord-335975-m6lkrehi 4317 11 adequate adequate JJ cord-335975-m6lkrehi 4317 12 empirical empirical JJ cord-335975-m6lkrehi 4317 13 antibiotic antibiotic JJ cord-335975-m6lkrehi 4317 14 therapy therapy NN cord-335975-m6lkrehi 4317 15 guidelines guideline NNS cord-335975-m6lkrehi 4317 16 ( ( -LRB- cord-335975-m6lkrehi 4317 17 log log NN cord-335975-m6lkrehi 4317 18 rank rank NN cord-335975-m6lkrehi 4317 19 , , , cord-335975-m6lkrehi 4317 20 p p NN cord-335975-m6lkrehi 4317 21 = = SYM cord-335975-m6lkrehi 4317 22 0.53 0.53 CD cord-335975-m6lkrehi 4317 23 ) ) -RRB- cord-335975-m6lkrehi 4317 24 in in IN cord-335975-m6lkrehi 4317 25 14 14 CD cord-335975-m6lkrehi 4317 26 cases case NNS cord-335975-m6lkrehi 4317 27 . . . cord-335975-m6lkrehi 4318 1 Mechanical mechanical JJ cord-335975-m6lkrehi 4318 2 ventilation ventilation NN cord-335975-m6lkrehi 4318 3 was be VBD cord-335975-m6lkrehi 4318 4 required require VBN cord-335975-m6lkrehi 4318 5 in in IN cord-335975-m6lkrehi 4318 6 58 58 CD cord-335975-m6lkrehi 4318 7 % % NN cord-335975-m6lkrehi 4318 8 of of IN cord-335975-m6lkrehi 4318 9 cases case NNS cord-335975-m6lkrehi 4318 10 ( ( -LRB- cord-335975-m6lkrehi 4318 11 n n NN cord-335975-m6lkrehi 4318 12 = = SYM cord-335975-m6lkrehi 4318 13 14 14 CD cord-335975-m6lkrehi 4318 14 % % NN cord-335975-m6lkrehi 4318 15 ) ) -RRB- cord-335975-m6lkrehi 4318 16 with with IN cord-335975-m6lkrehi 4318 17 a a DT cord-335975-m6lkrehi 4318 18 mean mean JJ cord-335975-m6lkrehi 4318 19 duration duration NN cord-335975-m6lkrehi 4318 20 of of IN cord-335975-m6lkrehi 4318 21 23 23 CD cord-335975-m6lkrehi 4318 22 ± ± NNP cord-335975-m6lkrehi 4318 23 8 8 CD cord-335975-m6lkrehi 4318 24 heures heure NNS cord-335975-m6lkrehi 4318 25 . . . cord-335975-m6lkrehi 4319 1 The the DT cord-335975-m6lkrehi 4319 2 mean mean JJ cord-335975-m6lkrehi 4319 3 duration duration NN cord-335975-m6lkrehi 4319 4 of of IN cord-335975-m6lkrehi 4319 5 ICU ICU NNP cord-335975-m6lkrehi 4319 6 stay stay NN cord-335975-m6lkrehi 4319 7 was be VBD cord-335975-m6lkrehi 4319 8 of of IN cord-335975-m6lkrehi 4319 9 50 50 CD cord-335975-m6lkrehi 4319 10 ± ± NNP cord-335975-m6lkrehi 4319 11 30 30 CD cord-335975-m6lkrehi 4319 12 h. h. NN cord-335975-m6lkrehi 4319 13 Twenty Twenty NNP cord-335975-m6lkrehi 4319 14 three three CD cord-335975-m6lkrehi 4319 15 patients patient NNS cord-335975-m6lkrehi 4319 16 recovered recover VBN cord-335975-m6lkrehi 4319 17 during during IN cord-335975-m6lkrehi 4319 18 the the DT cord-335975-m6lkrehi 4319 19 hospitalisation hospitalisation NN cord-335975-m6lkrehi 4319 20 , , , cord-335975-m6lkrehi 4319 21 one one CD cord-335975-m6lkrehi 4319 22 patient patient NN cord-335975-m6lkrehi 4319 23 died die VBD cord-335975-m6lkrehi 4319 24 with with IN cord-335975-m6lkrehi 4319 25 severe severe JJ cord-335975-m6lkrehi 4319 26 poisoning poisoning NN cord-335975-m6lkrehi 4319 27 . . . cord-335975-m6lkrehi 4320 1 Conclusion conclusion NN cord-335975-m6lkrehi 4320 2 : : : cord-335975-m6lkrehi 4321 1 As as IN cord-335975-m6lkrehi 4321 2 showed show VBN cord-335975-m6lkrehi 4321 3 in in IN cord-335975-m6lkrehi 4321 4 this this DT cord-335975-m6lkrehi 4321 5 study study NN cord-335975-m6lkrehi 4321 6 , , , cord-335975-m6lkrehi 4321 7 acute acute JJ cord-335975-m6lkrehi 4321 8 olazapine olazapine JJ cord-335975-m6lkrehi 4321 9 poisoning poisoning NN cord-335975-m6lkrehi 4321 10 could could MD cord-335975-m6lkrehi 4321 11 be be VB cord-335975-m6lkrehi 4321 12 severe severe JJ cord-335975-m6lkrehi 4321 13 , , , cord-335975-m6lkrehi 4321 14 and and CC cord-335975-m6lkrehi 4321 15 lead lead VB cord-335975-m6lkrehi 4321 16 to to IN cord-335975-m6lkrehi 4321 17 death death NN cord-335975-m6lkrehi 4321 18 sometimes sometimes RB cord-335975-m6lkrehi 4321 19 . . . cord-335975-m6lkrehi 4322 1 Introduction introduction NN cord-335975-m6lkrehi 4322 2 : : : cord-335975-m6lkrehi 4323 1 Voluntary voluntary JJ cord-335975-m6lkrehi 4323 2 drug drug NN cord-335975-m6lkrehi 4323 3 intoxication intoxication NN cord-335975-m6lkrehi 4323 4 ( ( -LRB- cord-335975-m6lkrehi 4323 5 VDI VDI NNP cord-335975-m6lkrehi 4323 6 ) ) -RRB- cord-335975-m6lkrehi 4323 7 continues continue VBZ cord-335975-m6lkrehi 4323 8 to to TO cord-335975-m6lkrehi 4323 9 be be VB cord-335975-m6lkrehi 4323 10 a a DT cord-335975-m6lkrehi 4323 11 major major JJ cord-335975-m6lkrehi 4323 12 health health NN cord-335975-m6lkrehi 4323 13 problem problem NN cord-335975-m6lkrehi 4323 14 in in IN cord-335975-m6lkrehi 4323 15 many many JJ cord-335975-m6lkrehi 4323 16 developed develop VBN cord-335975-m6lkrehi 4323 17 and and CC cord-335975-m6lkrehi 4323 18 developing develop VBG cord-335975-m6lkrehi 4323 19 countries country NNS cord-335975-m6lkrehi 4323 20 . . . cord-335975-m6lkrehi 4324 1 In in IN cord-335975-m6lkrehi 4324 2 Algeria Algeria NNP cord-335975-m6lkrehi 4324 3 , , , cord-335975-m6lkrehi 4324 4 this this DT cord-335975-m6lkrehi 4324 5 has have VBZ cord-335975-m6lkrehi 4324 6 become become VBN cord-335975-m6lkrehi 4324 7 a a DT cord-335975-m6lkrehi 4324 8 worrying worrying JJ cord-335975-m6lkrehi 4324 9 concern concern NN cord-335975-m6lkrehi 4324 10 . . . cord-335975-m6lkrehi 4325 1 Awareness awareness NN cord-335975-m6lkrehi 4325 2 - - HYPH cord-335975-m6lkrehi 4325 3 raising raising NN cord-335975-m6lkrehi 4325 4 is be VBZ cord-335975-m6lkrehi 4325 5 launched launch VBN cord-335975-m6lkrehi 4325 6 to to TO cord-335975-m6lkrehi 4325 7 prevent prevent VB cord-335975-m6lkrehi 4325 8 the the DT cord-335975-m6lkrehi 4325 9 public public NN cord-335975-m6lkrehi 4325 10 from from IN cord-335975-m6lkrehi 4325 11 these these DT cord-335975-m6lkrehi 4325 12 dangers danger NNS cord-335975-m6lkrehi 4325 13 . . . cord-335975-m6lkrehi 4326 1 VDI VDI NNP cord-335975-m6lkrehi 4326 2 are be VBP cord-335975-m6lkrehi 4326 3 intentional intentional JJ cord-335975-m6lkrehi 4326 4 or or CC cord-335975-m6lkrehi 4326 5 rarely rarely RB cord-335975-m6lkrehi 4326 6 accidental accidental JJ cord-335975-m6lkrehi 4326 7 and and CC cord-335975-m6lkrehi 4326 8 can can MD cord-335975-m6lkrehi 4326 9 be be VB cord-335975-m6lkrehi 4326 10 individual individual JJ cord-335975-m6lkrehi 4326 11 or or CC cord-335975-m6lkrehi 4326 12 collective collective JJ cord-335975-m6lkrehi 4326 13 and and CC cord-335975-m6lkrehi 4326 14 affect affect VB cord-335975-m6lkrehi 4326 15 all all DT cord-335975-m6lkrehi 4326 16 age age NN cord-335975-m6lkrehi 4326 17 groups group NNS cord-335975-m6lkrehi 4326 18 . . . cord-335975-m6lkrehi 4327 1 The the DT cord-335975-m6lkrehi 4327 2 VDI VDI NNP cord-335975-m6lkrehi 4327 3 represents represent VBZ cord-335975-m6lkrehi 4327 4 the the DT cord-335975-m6lkrehi 4327 5 first first JJ cord-335975-m6lkrehi 4327 6 reason reason NN cord-335975-m6lkrehi 4327 7 for for IN cord-335975-m6lkrehi 4327 8 hospitalization hospitalization NN cord-335975-m6lkrehi 4327 9 in in IN cord-335975-m6lkrehi 4327 10 the the DT cord-335975-m6lkrehi 4327 11 Emergency Emergency NNP cord-335975-m6lkrehi 4327 12 Department Department NNP cord-335975-m6lkrehi 4327 13 University University NNP cord-335975-m6lkrehi 4327 14 hospital hospital NN cord-335975-m6lkrehi 4327 15 of of IN cord-335975-m6lkrehi 4327 16 Oran Oran NNP cord-335975-m6lkrehi 4327 17 . . . cord-335975-m6lkrehi 4328 1 In in IN cord-335975-m6lkrehi 4328 2 Algeria Algeria NNP cord-335975-m6lkrehi 4328 3 there there EX cord-335975-m6lkrehi 4328 4 is be VBZ cord-335975-m6lkrehi 4328 5 no no DT cord-335975-m6lkrehi 4328 6 national national JJ cord-335975-m6lkrehi 4328 7 or or CC cord-335975-m6lkrehi 4328 8 regional regional JJ cord-335975-m6lkrehi 4328 9 register register NN cord-335975-m6lkrehi 4328 10 of of IN cord-335975-m6lkrehi 4328 11 voluntary voluntary JJ cord-335975-m6lkrehi 4328 12 intoxication intoxication NN cord-335975-m6lkrehi 4328 13 . . . cord-335975-m6lkrehi 4329 1 Knowledge knowledge NN cord-335975-m6lkrehi 4329 2 of of IN cord-335975-m6lkrehi 4329 3 the the DT cord-335975-m6lkrehi 4329 4 causes cause NNS cord-335975-m6lkrehi 4329 5 of of IN cord-335975-m6lkrehi 4329 6 drug drug NN cord-335975-m6lkrehi 4329 7 poisoning poisoning NN cord-335975-m6lkrehi 4329 8 should should MD cord-335975-m6lkrehi 4329 9 therefore therefore RB cord-335975-m6lkrehi 4329 10 be be VB cord-335975-m6lkrehi 4329 11 extrapolated extrapolate VBN cord-335975-m6lkrehi 4329 12 from from IN cord-335975-m6lkrehi 4329 13 foreign foreign JJ cord-335975-m6lkrehi 4329 14 studies study NNS cord-335975-m6lkrehi 4329 15 . . . cord-335975-m6lkrehi 4330 1 To to TO cord-335975-m6lkrehi 4330 2 draw draw VB cord-335975-m6lkrehi 4330 3 up up RP cord-335975-m6lkrehi 4330 4 an an DT cord-335975-m6lkrehi 4330 5 assessment assessment NN cord-335975-m6lkrehi 4330 6 of of IN cord-335975-m6lkrehi 4330 7 the the DT cord-335975-m6lkrehi 4330 8 IMVs imv NNS cord-335975-m6lkrehi 4330 9 , , , cord-335975-m6lkrehi 4330 10 a a DT cord-335975-m6lkrehi 4330 11 retrospective retrospective JJ cord-335975-m6lkrehi 4330 12 study study NN cord-335975-m6lkrehi 4330 13 was be VBD cord-335975-m6lkrehi 4330 14 carried carry VBN cord-335975-m6lkrehi 4330 15 out out RP cord-335975-m6lkrehi 4330 16 over over IN cord-335975-m6lkrehi 4330 17 the the DT cord-335975-m6lkrehi 4330 18 2 2 CD cord-335975-m6lkrehi 4330 19 years year NNS cord-335975-m6lkrehi 4330 20 ( ( -LRB- cord-335975-m6lkrehi 4330 21 2015 2015 CD cord-335975-m6lkrehi 4330 22 - - SYM cord-335975-m6lkrehi 4330 23 2016 2016 CD cord-335975-m6lkrehi 4330 24 ) ) -RRB- cord-335975-m6lkrehi 4330 25 . . . cord-335975-m6lkrehi 4331 1 This this DT cord-335975-m6lkrehi 4331 2 survey survey NN cord-335975-m6lkrehi 4331 3 consisted consist VBD cord-335975-m6lkrehi 4331 4 of of IN cord-335975-m6lkrehi 4331 5 collecting collect VBG cord-335975-m6lkrehi 4331 6 data datum NNS cord-335975-m6lkrehi 4331 7 on on IN cord-335975-m6lkrehi 4331 8 the the DT cord-335975-m6lkrehi 4331 9 nature nature NN cord-335975-m6lkrehi 4331 10 of of IN cord-335975-m6lkrehi 4331 11 the the DT cord-335975-m6lkrehi 4331 12 drug drug NN cord-335975-m6lkrehi 4331 13 , , , cord-335975-m6lkrehi 4331 14 age age NN cord-335975-m6lkrehi 4331 15 , , , cord-335975-m6lkrehi 4331 16 sex sex NN cord-335975-m6lkrehi 4331 17 , , , cord-335975-m6lkrehi 4331 18 major major JJ cord-335975-m6lkrehi 4331 19 toxidromes toxidrome NNS cord-335975-m6lkrehi 4331 20 , , , cord-335975-m6lkrehi 4331 21 severe severe JJ cord-335975-m6lkrehi 4331 22 IMVs imv NNS cord-335975-m6lkrehi 4331 23 requiring require VBG cord-335975-m6lkrehi 4331 24 hospitalization hospitalization NN cord-335975-m6lkrehi 4331 25 in in IN cord-335975-m6lkrehi 4331 26 ICU ICU NNP cord-335975-m6lkrehi 4331 27 , , , cord-335975-m6lkrehi 4331 28 mortality mortality NN cord-335975-m6lkrehi 4331 29 , , , cord-335975-m6lkrehi 4331 30 E.T.C E.T.C NNP cord-335975-m6lkrehi 4331 31 scores score NNS cord-335975-m6lkrehi 4331 32 and and CC cord-335975-m6lkrehi 4331 33 GLASGO GLASGO NNP cord-335975-m6lkrehi 4331 34 scores score NNS cord-335975-m6lkrehi 4331 35 . . . cord-335975-m6lkrehi 4332 1 Results result NNS cord-335975-m6lkrehi 4332 2 : : : cord-335975-m6lkrehi 4333 1 1650 1650 CD cord-335975-m6lkrehi 4333 2 cases case NNS cord-335975-m6lkrehi 4333 3 of of IN cord-335975-m6lkrehi 4333 4 acute acute JJ cord-335975-m6lkrehi 4333 5 poisoning poisoning NN cord-335975-m6lkrehi 4333 6 were be VBD cord-335975-m6lkrehi 4333 7 collected collect VBN cord-335975-m6lkrehi 4333 8 , , , cord-335975-m6lkrehi 4333 9 with with IN cord-335975-m6lkrehi 4333 10 a a DT cord-335975-m6lkrehi 4333 11 predominance predominance NN cord-335975-m6lkrehi 4333 12 in in IN cord-335975-m6lkrehi 4333 13 patients patient NNS cord-335975-m6lkrehi 4333 14 aged age VBN cord-335975-m6lkrehi 4333 15 between between IN cord-335975-m6lkrehi 4333 16 16 16 CD cord-335975-m6lkrehi 4333 17 and and CC cord-335975-m6lkrehi 4333 18 25 25 CD cord-335975-m6lkrehi 4333 19 , , , cord-335975-m6lkrehi 4333 20 a a DT cord-335975-m6lkrehi 4333 21 percentage percentage NN cord-335975-m6lkrehi 4333 22 of of IN cord-335975-m6lkrehi 4333 23 31.77 31.77 CD cord-335975-m6lkrehi 4333 24 % % NN cord-335975-m6lkrehi 4333 25 . . . cord-335975-m6lkrehi 4334 1 In in IN cord-335975-m6lkrehi 4334 2 addition addition NN cord-335975-m6lkrehi 4334 3 , , , cord-335975-m6lkrehi 4334 4 most most JJS cord-335975-m6lkrehi 4334 5 patients patient NNS cord-335975-m6lkrehi 4334 6 were be VBD cord-335975-m6lkrehi 4334 7 female female JJ cord-335975-m6lkrehi 4334 8 with with IN cord-335975-m6lkrehi 4334 9 60.98 60.98 CD cord-335975-m6lkrehi 4334 10 % % NN cord-335975-m6lkrehi 4334 11 , , , cord-335975-m6lkrehi 4334 12 a a DT cord-335975-m6lkrehi 4334 13 sex sex NN cord-335975-m6lkrehi 4334 14 ratio ratio NN cord-335975-m6lkrehi 4334 15 of of IN cord-335975-m6lkrehi 4334 16 1.56 1.56 CD cord-335975-m6lkrehi 4334 17 with with IN cord-335975-m6lkrehi 4334 18 p p NN cord-335975-m6lkrehi 4334 19 < < XX cord-335975-m6lkrehi 4334 20 0.05 0.05 CD cord-335975-m6lkrehi 4334 21 . . . cord-335975-m6lkrehi 4335 1 The the DT cord-335975-m6lkrehi 4335 2 main main JJ cord-335975-m6lkrehi 4335 3 toxidromes toxidrome NNS cord-335975-m6lkrehi 4335 4 were be VBD cord-335975-m6lkrehi 4335 5 - - HYPH cord-335975-m6lkrehi 4335 6 opioid opioid NN cord-335975-m6lkrehi 4335 7 syndrome syndrome NN cord-335975-m6lkrehi 4335 8 in in IN cord-335975-m6lkrehi 4335 9 27 27 CD cord-335975-m6lkrehi 4335 10 % % NN cord-335975-m6lkrehi 4335 11 of of IN cord-335975-m6lkrehi 4335 12 cases case NNS cord-335975-m6lkrehi 4335 13 and and CC cord-335975-m6lkrehi 4335 14 anticholinergic anticholinergic JJ cord-335975-m6lkrehi 4335 15 syndrome syndrome NN cord-335975-m6lkrehi 4335 16 in in IN cord-335975-m6lkrehi 4335 17 23 23 CD cord-335975-m6lkrehi 4335 18 % % NN cord-335975-m6lkrehi 4335 19 of of IN cord-335975-m6lkrehi 4335 20 cases case NNS cord-335975-m6lkrehi 4335 21 . . . cord-335975-m6lkrehi 4336 1 ETC ETC NNS cord-335975-m6lkrehi 4336 2 with with IN cord-335975-m6lkrehi 4336 3 a a DT cord-335975-m6lkrehi 4336 4 score score NN cord-335975-m6lkrehi 4336 5 of of IN cord-335975-m6lkrehi 4336 6 > > NN cord-335975-m6lkrehi 4336 7 9 9 CD cord-335975-m6lkrehi 4336 8 % % NN cord-335975-m6lkrehi 4336 9 accounted account VBD cord-335975-m6lkrehi 4336 10 for for IN cord-335975-m6lkrehi 4336 11 93 93 CD cord-335975-m6lkrehi 4336 12 % % NN cord-335975-m6lkrehi 4336 13 of of IN cord-335975-m6lkrehi 4336 14 patients patient NNS cord-335975-m6lkrehi 4336 15 . . . cord-335975-m6lkrehi 4337 1 Severe severe JJ cord-335975-m6lkrehi 4337 2 VDI VDI NNP cord-335975-m6lkrehi 4337 3 requiring require VBG cord-335975-m6lkrehi 4337 4 resuscitation resuscitation NN cord-335975-m6lkrehi 4337 5 hospitalization hospitalization NN cord-335975-m6lkrehi 4337 6 were be VBD cord-335975-m6lkrehi 4337 7 8 8 CD cord-335975-m6lkrehi 4337 8 % % NN cord-335975-m6lkrehi 4337 9 . . . cord-335975-m6lkrehi 4338 1 Conclusion conclusion NN cord-335975-m6lkrehi 4338 2 : : : cord-335975-m6lkrehi 4339 1 Acute acute JJ cord-335975-m6lkrehi 4339 2 poisoning poisoning NN cord-335975-m6lkrehi 4339 3 remains remain VBZ cord-335975-m6lkrehi 4339 4 high high JJ cord-335975-m6lkrehi 4339 5 and and CC cord-335975-m6lkrehi 4339 6 steady steady JJ cord-335975-m6lkrehi 4339 7 in in IN cord-335975-m6lkrehi 4339 8 the the DT cord-335975-m6lkrehi 4339 9 Oran Oran NNP cord-335975-m6lkrehi 4339 10 region region NN cord-335975-m6lkrehi 4339 11 and and CC cord-335975-m6lkrehi 4339 12 the the DT cord-335975-m6lkrehi 4339 13 under-25 under-25 NNP cord-335975-m6lkrehi 4339 14 age age NN cord-335975-m6lkrehi 4339 15 group group NN cord-335975-m6lkrehi 4339 16 represents represent VBZ cord-335975-m6lkrehi 4339 17 the the DT cord-335975-m6lkrehi 4339 18 most most RBS cord-335975-m6lkrehi 4339 19 affected affect VBN cord-335975-m6lkrehi 4339 20 category category NN cord-335975-m6lkrehi 4339 21 . . . cord-335975-m6lkrehi 4340 1 Awareness awareness NN cord-335975-m6lkrehi 4340 2 campaigns campaign NNS cord-335975-m6lkrehi 4340 3 must must MD cord-335975-m6lkrehi 4340 4 be be VB cord-335975-m6lkrehi 4340 5 launched launch VBN cord-335975-m6lkrehi 4340 6 throughout throughout IN cord-335975-m6lkrehi 4340 7 the the DT cord-335975-m6lkrehi 4340 8 year year NN cord-335975-m6lkrehi 4340 9 to to TO cord-335975-m6lkrehi 4340 10 better better RB cord-335975-m6lkrehi 4340 11 conserve conserve VB cord-335975-m6lkrehi 4340 12 and and CC cord-335975-m6lkrehi 4340 13 store store VB cord-335975-m6lkrehi 4340 14 medicines medicine NNS cord-335975-m6lkrehi 4340 15 , , , cord-335975-m6lkrehi 4340 16 phytosanitary phytosanitary NNP cord-335975-m6lkrehi 4340 17 products product NNS cord-335975-m6lkrehi 4340 18 and and CC cord-335975-m6lkrehi 4340 19 other other JJ cord-335975-m6lkrehi 4340 20 chemicals chemical NNS cord-335975-m6lkrehi 4340 21 . . . cord-335975-m6lkrehi 4341 1 Improved improve VBN cord-335975-m6lkrehi 4341 2 socio socio JJ cord-335975-m6lkrehi 4341 3 - - HYPH cord-335975-m6lkrehi 4341 4 economic economic JJ cord-335975-m6lkrehi 4341 5 conditions condition NNS cord-335975-m6lkrehi 4341 6 would would MD cord-335975-m6lkrehi 4341 7 help help VB cord-335975-m6lkrehi 4341 8 to to TO cord-335975-m6lkrehi 4341 9 reduce reduce VB cord-335975-m6lkrehi 4341 10 voluntary voluntary JJ cord-335975-m6lkrehi 4341 11 intoxication intoxication NN cord-335975-m6lkrehi 4341 12 . . . cord-335975-m6lkrehi 4342 1 Introduction introduction NN cord-335975-m6lkrehi 4342 2 : : : cord-335975-m6lkrehi 4343 1 Scorpionic scorpionic JJ cord-335975-m6lkrehi 4343 2 envenomation envenomation NN cord-335975-m6lkrehi 4343 3 is be VBZ cord-335975-m6lkrehi 4343 4 unevenly unevenly RB cord-335975-m6lkrehi 4343 5 distributed distribute VBN cord-335975-m6lkrehi 4343 6 throughout throughout IN cord-335975-m6lkrehi 4343 7 the the DT cord-335975-m6lkrehi 4343 8 world world NN cord-335975-m6lkrehi 4343 9 and and CC cord-335975-m6lkrehi 4343 10 is be VBZ cord-335975-m6lkrehi 4343 11 particularly particularly RB cord-335975-m6lkrehi 4343 12 frequent frequent JJ cord-335975-m6lkrehi 4343 13 in in IN cord-335975-m6lkrehi 4343 14 some some DT cord-335975-m6lkrehi 4343 15 regions region NNS cord-335975-m6lkrehi 4343 16 of of IN cord-335975-m6lkrehi 4343 17 the the DT cord-335975-m6lkrehi 4343 18 world world NN cord-335975-m6lkrehi 4343 19 , , , cord-335975-m6lkrehi 4343 20 notably notably RB cord-335975-m6lkrehi 4343 21 North North NNP cord-335975-m6lkrehi 4343 22 Africa Africa NNP cord-335975-m6lkrehi 4343 23 . . . cord-335975-m6lkrehi 4344 1 The the DT cord-335975-m6lkrehi 4344 2 purpose purpose NN cord-335975-m6lkrehi 4344 3 of of IN cord-335975-m6lkrehi 4344 4 this this DT cord-335975-m6lkrehi 4344 5 work work NN cord-335975-m6lkrehi 4344 6 is be VBZ cord-335975-m6lkrehi 4344 7 to to TO cord-335975-m6lkrehi 4344 8 describe describe VB cord-335975-m6lkrehi 4344 9 the the DT cord-335975-m6lkrehi 4344 10 epidemiological epidemiological JJ cord-335975-m6lkrehi 4344 11 profile profile NN cord-335975-m6lkrehi 4344 12 of of IN cord-335975-m6lkrehi 4344 13 the the DT cord-335975-m6lkrehi 4344 14 scorpionic scorpionic NNP cord-335975-m6lkrehi 4344 15 envenomations envenomations NNP cord-335975-m6lkrehi 4344 16 admitted admit VBD cord-335975-m6lkrehi 4344 17 to to IN cord-335975-m6lkrehi 4344 18 the the DT cord-335975-m6lkrehi 4344 19 resuscitation resuscitation NN cord-335975-m6lkrehi 4344 20 department department NN cord-335975-m6lkrehi 4344 21 of of IN cord-335975-m6lkrehi 4344 22 Mahres Mahres NNP cord-335975-m6lkrehi 4344 23 . . . cord-335975-m6lkrehi 4345 1 Patients patient NNS cord-335975-m6lkrehi 4345 2 and and CC cord-335975-m6lkrehi 4345 3 methods method NNS cord-335975-m6lkrehi 4345 4 : : : cord-335975-m6lkrehi 4345 5 A a DT cord-335975-m6lkrehi 4345 6 prospective prospective JJ cord-335975-m6lkrehi 4345 7 study study NN cord-335975-m6lkrehi 4345 8 conducted conduct VBN cord-335975-m6lkrehi 4345 9 at at IN cord-335975-m6lkrehi 4345 10 the the DT cord-335975-m6lkrehi 4345 11 Mahres Mahres NNPS cord-335975-m6lkrehi 4345 12 intensive intensive JJ cord-335975-m6lkrehi 4345 13 care care NN cord-335975-m6lkrehi 4345 14 unit unit NN cord-335975-m6lkrehi 4345 15 over over IN cord-335975-m6lkrehi 4345 16 a a DT cord-335975-m6lkrehi 4345 17 period period NN cord-335975-m6lkrehi 4345 18 of of IN cord-335975-m6lkrehi 4345 19 6 6 CD cord-335975-m6lkrehi 4345 20 months month NNS cord-335975-m6lkrehi 4345 21 ( ( -LRB- cord-335975-m6lkrehi 4345 22 15 15 CD cord-335975-m6lkrehi 4345 23 02 02 CD cord-335975-m6lkrehi 4345 24 2017 2017 CD cord-335975-m6lkrehi 4345 25 until until IN cord-335975-m6lkrehi 4345 26 15 15 CD cord-335975-m6lkrehi 4345 27 08 08 CD cord-335975-m6lkrehi 4345 28 2017 2017 CD cord-335975-m6lkrehi 4345 29 ) ) -RRB- cord-335975-m6lkrehi 4345 30 , , , cord-335975-m6lkrehi 4345 31 including include VBG cord-335975-m6lkrehi 4345 32 all all DT cord-335975-m6lkrehi 4345 33 patients patient NNS cord-335975-m6lkrehi 4345 34 admitted admit VBN cord-335975-m6lkrehi 4345 35 for for IN cord-335975-m6lkrehi 4345 36 scorpion scorpion NN cord-335975-m6lkrehi 4345 37 envenomation envenomation NN cord-335975-m6lkrehi 4345 38 . . . cord-335975-m6lkrehi 4346 1 Results result NNS cord-335975-m6lkrehi 4346 2 : : : cord-335975-m6lkrehi 4347 1 We -PRON- PRP cord-335975-m6lkrehi 4347 2 collected collect VBD cord-335975-m6lkrehi 4347 3 102 102 CD cord-335975-m6lkrehi 4347 4 cases case NNS cord-335975-m6lkrehi 4347 5 of of IN cord-335975-m6lkrehi 4347 6 patients patient NNS cord-335975-m6lkrehi 4347 7 admitted admit VBN cord-335975-m6lkrehi 4347 8 to to IN cord-335975-m6lkrehi 4347 9 the the DT cord-335975-m6lkrehi 4347 10 resuscitation resuscitation NN cord-335975-m6lkrehi 4347 11 department department NN cord-335975-m6lkrehi 4347 12 of of IN cord-335975-m6lkrehi 4347 13 Mahres Mahres NNPS cord-335975-m6lkrehi 4347 14 from from IN cord-335975-m6lkrehi 4347 15 15 15 CD cord-335975-m6lkrehi 4347 16 02 02 CD cord-335975-m6lkrehi 4347 17 2017 2017 CD cord-335975-m6lkrehi 4347 18 to to IN cord-335975-m6lkrehi 4347 19 15 15 CD cord-335975-m6lkrehi 4347 20 08 08 CD cord-335975-m6lkrehi 4347 21 2017 2017 CD cord-335975-m6lkrehi 4347 22 , , , cord-335975-m6lkrehi 4347 23 including include VBG cord-335975-m6lkrehi 4347 24 10 10 CD cord-335975-m6lkrehi 4347 25 cases case NNS cord-335975-m6lkrehi 4347 26 of of IN cord-335975-m6lkrehi 4347 27 scorpionic scorpionic NNP cord-335975-m6lkrehi 4347 28 envenomations envenomations NNP cord-335975-m6lkrehi 4347 29 , , , cord-335975-m6lkrehi 4347 30 i.e. i.e. FW cord-335975-m6lkrehi 4347 31 0.098 0.098 CD cord-335975-m6lkrehi 4347 32 % % NN cord-335975-m6lkrehi 4347 33 . . . cord-335975-m6lkrehi 4348 1 The the DT cord-335975-m6lkrehi 4348 2 median median JJ cord-335975-m6lkrehi 4348 3 age age NN cord-335975-m6lkrehi 4348 4 was be VBD cord-335975-m6lkrehi 4348 5 43 43 CD cord-335975-m6lkrehi 4348 6 years year NNS cord-335975-m6lkrehi 4348 7 with with IN cord-335975-m6lkrehi 4348 8 extremes extreme NNS cord-335975-m6lkrehi 4348 9 ranging range VBG cord-335975-m6lkrehi 4348 10 from from IN cord-335975-m6lkrehi 4348 11 20 20 CD cord-335975-m6lkrehi 4348 12 to to TO cord-335975-m6lkrehi 4348 13 78 78 CD cord-335975-m6lkrehi 4348 14 years year NNS cord-335975-m6lkrehi 4348 15 . . . cord-335975-m6lkrehi 4349 1 The the DT cord-335975-m6lkrehi 4349 2 sex sex NN cord-335975-m6lkrehi 4349 3 ratio ratio NN cord-335975-m6lkrehi 4349 4 was be VBD cord-335975-m6lkrehi 4349 5 4 4 CD cord-335975-m6lkrehi 4349 6 . . . cord-335975-m6lkrehi 4350 1 Scorpion scorpion NN cord-335975-m6lkrehi 4350 2 stings sting NNS cord-335975-m6lkrehi 4350 3 occurred occur VBD cord-335975-m6lkrehi 4350 4 at at IN cord-335975-m6lkrehi 4350 5 night night NN cord-335975-m6lkrehi 4350 6 in in IN cord-335975-m6lkrehi 4350 7 80 80 CD cord-335975-m6lkrehi 4350 8 % % NN cord-335975-m6lkrehi 4350 9 of of IN cord-335975-m6lkrehi 4350 10 patients patient NNS cord-335975-m6lkrehi 4350 11 , , , cord-335975-m6lkrehi 4350 12 60 60 CD cord-335975-m6lkrehi 4350 13 % % NN cord-335975-m6lkrehi 4350 14 in in IN cord-335975-m6lkrehi 4350 15 the the DT cord-335975-m6lkrehi 4350 16 first first JJ cord-335975-m6lkrehi 4350 17 half half NN cord-335975-m6lkrehi 4350 18 of of IN cord-335975-m6lkrehi 4350 19 the the DT cord-335975-m6lkrehi 4350 20 night night NN cord-335975-m6lkrehi 4350 21 ( ( -LRB- cord-335975-m6lkrehi 4350 22 between between IN cord-335975-m6lkrehi 4350 23 6 6 CD cord-335975-m6lkrehi 4350 24 pm pm NN cord-335975-m6lkrehi 4350 25 and and CC cord-335975-m6lkrehi 4350 26 11 11 CD cord-335975-m6lkrehi 4350 27 - - SYM cord-335975-m6lkrehi 4350 28 59 59 CD cord-335975-m6lkrehi 4350 29 pm pm NN cord-335975-m6lkrehi 4350 30 ) ) -RRB- cord-335975-m6lkrehi 4350 31 and and CC cord-335975-m6lkrehi 4350 32 20 20 CD cord-335975-m6lkrehi 4350 33 % % NN cord-335975-m6lkrehi 4350 34 in in IN cord-335975-m6lkrehi 4350 35 the the DT cord-335975-m6lkrehi 4350 36 second second JJ cord-335975-m6lkrehi 4350 37 half half NN cord-335975-m6lkrehi 4350 38 of of IN cord-335975-m6lkrehi 4350 39 the the DT cord-335975-m6lkrehi 4350 40 night night NN cord-335975-m6lkrehi 4350 41 ( ( -LRB- cord-335975-m6lkrehi 4350 42 0 0 CD cord-335975-m6lkrehi 4350 43 to to IN cord-335975-m6lkrehi 4350 44 5 5 CD cord-335975-m6lkrehi 4350 45 h h NN cord-335975-m6lkrehi 4350 46 ) ) -RRB- cord-335975-m6lkrehi 4350 47 . . . cord-335975-m6lkrehi 4351 1 Venom venom NN cord-335975-m6lkrehi 4351 2 inoculation inoculation NN cord-335975-m6lkrehi 4351 3 points point NNS cord-335975-m6lkrehi 4351 4 were be VBD cord-335975-m6lkrehi 4351 5 in in IN cord-335975-m6lkrehi 4351 6 the the DT cord-335975-m6lkrehi 4351 7 lower low JJR cord-335975-m6lkrehi 4351 8 limbs limb NNS cord-335975-m6lkrehi 4351 9 in in IN cord-335975-m6lkrehi 4351 10 80 80 CD cord-335975-m6lkrehi 4351 11 % % NN cord-335975-m6lkrehi 4351 12 of of IN cord-335975-m6lkrehi 4351 13 cases case NNS cord-335975-m6lkrehi 4351 14 , , , cord-335975-m6lkrehi 4351 15 followed follow VBN cord-335975-m6lkrehi 4351 16 by by IN cord-335975-m6lkrehi 4351 17 upper upper JJ cord-335975-m6lkrehi 4351 18 limbs limb NNS cord-335975-m6lkrehi 4351 19 ( ( -LRB- cord-335975-m6lkrehi 4351 20 20 20 CD cord-335975-m6lkrehi 4351 21 % % NN cord-335975-m6lkrehi 4351 22 ) ) -RRB- cord-335975-m6lkrehi 4351 23 . . . cord-335975-m6lkrehi 4352 1 The the DT cord-335975-m6lkrehi 4352 2 color color NN cord-335975-m6lkrehi 4352 3 of of IN cord-335975-m6lkrehi 4352 4 the the DT cord-335975-m6lkrehi 4352 5 incriminated incriminate VBN cord-335975-m6lkrehi 4352 6 scorpion scorpion NN cord-335975-m6lkrehi 4352 7 was be VBD cord-335975-m6lkrehi 4352 8 yellow yellow JJ cord-335975-m6lkrehi 4352 9 in in IN cord-335975-m6lkrehi 4352 10 80 80 CD cord-335975-m6lkrehi 4352 11 % % NN cord-335975-m6lkrehi 4352 12 , , , cord-335975-m6lkrehi 4352 13 black black JJ cord-335975-m6lkrehi 4352 14 in in IN cord-335975-m6lkrehi 4352 15 10 10 CD cord-335975-m6lkrehi 4352 16 % % NN cord-335975-m6lkrehi 4352 17 and and CC cord-335975-m6lkrehi 4352 18 unspecified unspecified JJ cord-335975-m6lkrehi 4352 19 in in IN cord-335975-m6lkrehi 4352 20 10 10 CD cord-335975-m6lkrehi 4352 21 % % NN cord-335975-m6lkrehi 4352 22 of of IN cord-335975-m6lkrehi 4352 23 the the DT cord-335975-m6lkrehi 4352 24 cases case NNS cord-335975-m6lkrehi 4352 25 . . . cord-335975-m6lkrehi 4353 1 For for IN cord-335975-m6lkrehi 4353 2 admission admission NN cord-335975-m6lkrehi 4353 3 classes class NNS cord-335975-m6lkrehi 4353 4 , , , cord-335975-m6lkrehi 4353 5 there there EX cord-335975-m6lkrehi 4353 6 were be VBD cord-335975-m6lkrehi 4353 7 10 10 CD cord-335975-m6lkrehi 4353 8 % % NN cord-335975-m6lkrehi 4353 9 Class class NN cord-335975-m6lkrehi 4353 10 I i NN cord-335975-m6lkrehi 4353 11 , , , cord-335975-m6lkrehi 4353 12 80 80 CD cord-335975-m6lkrehi 4353 13 % % NN cord-335975-m6lkrehi 4353 14 Class Class NNP cord-335975-m6lkrehi 4353 15 II II NNP cord-335975-m6lkrehi 4353 16 and and CC cord-335975-m6lkrehi 4353 17 10 10 CD cord-335975-m6lkrehi 4353 18 % % NN cord-335975-m6lkrehi 4353 19 Class class NN cord-335975-m6lkrehi 4353 20 III III NNP cord-335975-m6lkrehi 4353 21 . . . cord-335975-m6lkrehi 4354 1 The the DT cord-335975-m6lkrehi 4354 2 traditional traditional JJ cord-335975-m6lkrehi 4354 3 therapeutic therapeutic JJ cord-335975-m6lkrehi 4354 4 gestures gesture NNS cord-335975-m6lkrehi 4354 5 practiced practice VBN cord-335975-m6lkrehi 4354 6 by by IN cord-335975-m6lkrehi 4354 7 the the DT cord-335975-m6lkrehi 4354 8 patients patient NNS cord-335975-m6lkrehi 4354 9 or or CC cord-335975-m6lkrehi 4354 10 their -PRON- PRP$ cord-335975-m6lkrehi 4354 11 entourage entourage NN cord-335975-m6lkrehi 4354 12 were be VBD cord-335975-m6lkrehi 4354 13 the the DT cord-335975-m6lkrehi 4354 14 laying lay VBG cord-335975-m6lkrehi 4354 15 scarification scarification NN cord-335975-m6lkrehi 4354 16 ( ( -LRB- cord-335975-m6lkrehi 4354 17 50 50 CD cord-335975-m6lkrehi 4354 18 % % NN cord-335975-m6lkrehi 4354 19 ) ) -RRB- cord-335975-m6lkrehi 4354 20 and and CC cord-335975-m6lkrehi 4354 21 the the DT cord-335975-m6lkrehi 4354 22 suction suction NN cord-335975-m6lkrehi 4354 23 ( ( -LRB- cord-335975-m6lkrehi 4354 24 10 10 CD cord-335975-m6lkrehi 4354 25 % % NN cord-335975-m6lkrehi 4354 26 ) ) -RRB- cord-335975-m6lkrehi 4354 27 . . . cord-335975-m6lkrehi 4355 1 All all DT cord-335975-m6lkrehi 4355 2 patients patient NNS cord-335975-m6lkrehi 4355 3 received receive VBD cord-335975-m6lkrehi 4355 4 anti anti JJ cord-335975-m6lkrehi 4355 5 - - JJ cord-335975-m6lkrehi 4355 6 scorpion scorpion JJ cord-335975-m6lkrehi 4355 7 serum serum NN cord-335975-m6lkrehi 4355 8 , , , cord-335975-m6lkrehi 4355 9 an an DT cord-335975-m6lkrehi 4355 10 analgesic analgesic JJ cord-335975-m6lkrehi 4355 11 , , , cord-335975-m6lkrehi 4355 12 serum serum NN cord-335975-m6lkrehi 4355 13 and and CC cord-335975-m6lkrehi 4355 14 tetanus tetanus NN cord-335975-m6lkrehi 4355 15 vaccine vaccine NN cord-335975-m6lkrehi 4355 16 . . . cord-335975-m6lkrehi 4356 1 The the DT cord-335975-m6lkrehi 4356 2 progression progression NN cord-335975-m6lkrehi 4356 3 was be VBD cord-335975-m6lkrehi 4356 4 favorable favorable JJ cord-335975-m6lkrehi 4356 5 in in IN cord-335975-m6lkrehi 4356 6 all all DT cord-335975-m6lkrehi 4356 7 cases case NNS cord-335975-m6lkrehi 4356 8 after after IN cord-335975-m6lkrehi 4356 9 an an DT cord-335975-m6lkrehi 4356 10 average average JJ cord-335975-m6lkrehi 4356 11 hospital hospital NN cord-335975-m6lkrehi 4356 12 stay stay NN cord-335975-m6lkrehi 4356 13 of of IN cord-335975-m6lkrehi 4356 14 4 4 CD cord-335975-m6lkrehi 4356 15 ± ± CD cord-335975-m6lkrehi 4356 16 1 1 CD cord-335975-m6lkrehi 4356 17 days day NNS cord-335975-m6lkrehi 4356 18 . . . cord-335975-m6lkrehi 4357 1 Conclusion conclusion NN cord-335975-m6lkrehi 4357 2 : : : cord-335975-m6lkrehi 4358 1 Scorpionic scorpionic JJ cord-335975-m6lkrehi 4358 2 envenomations envenomation NNS cord-335975-m6lkrehi 4358 3 are be VBP cord-335975-m6lkrehi 4358 4 indeed indeed RB cord-335975-m6lkrehi 4358 5 a a DT cord-335975-m6lkrehi 4358 6 reality reality NN cord-335975-m6lkrehi 4358 7 in in IN cord-335975-m6lkrehi 4358 8 Mahres mahre NNS cord-335975-m6lkrehi 4358 9 with with IN cord-335975-m6lkrehi 4358 10 a a DT cord-335975-m6lkrehi 4358 11 non non JJ cord-335975-m6lkrehi 4358 12 - - JJ cord-335975-m6lkrehi 4358 13 negligible negligible JJ cord-335975-m6lkrehi 4358 14 frequency frequency NN cord-335975-m6lkrehi 4358 15 despite despite IN cord-335975-m6lkrehi 4358 16 under under IN cord-335975-m6lkrehi 4358 17 - - HYPH cord-335975-m6lkrehi 4358 18 reporting reporting NN cord-335975-m6lkrehi 4358 19 of of IN cord-335975-m6lkrehi 4358 20 cases case NNS cord-335975-m6lkrehi 4358 21 treated treat VBN cord-335975-m6lkrehi 4358 22 by by IN cord-335975-m6lkrehi 4358 23 traditional traditional JJ cord-335975-m6lkrehi 4358 24 medicine medicine NN cord-335975-m6lkrehi 4358 25 or or CC cord-335975-m6lkrehi 4358 26 in in IN cord-335975-m6lkrehi 4358 27 other other JJ cord-335975-m6lkrehi 4358 28 hospitals hospital NNS cord-335975-m6lkrehi 4358 29 . . . cord-335975-m6lkrehi 4359 1 They -PRON- PRP cord-335975-m6lkrehi 4359 2 mostly mostly RB cord-335975-m6lkrehi 4359 3 affect affect VBP cord-335975-m6lkrehi 4359 4 young young JJ cord-335975-m6lkrehi 4359 5 people people NNS cord-335975-m6lkrehi 4359 6 and and CC cord-335975-m6lkrehi 4359 7 the the DT cord-335975-m6lkrehi 4359 8 associated associate VBN cord-335975-m6lkrehi 4359 9 clinical clinical JJ cord-335975-m6lkrehi 4359 10 manifestations manifestation NNS cord-335975-m6lkrehi 4359 11 often often RB cord-335975-m6lkrehi 4359 12 remain remain VBP cord-335975-m6lkrehi 4359 13 benign benign JJ cord-335975-m6lkrehi 4359 14 . . . cord-335975-m6lkrehi 4360 1 Introduction introduction NN cord-335975-m6lkrehi 4360 2 : : : cord-335975-m6lkrehi 4361 1 Severe severe JJ cord-335975-m6lkrehi 4361 2 pediatric pediatric JJ cord-335975-m6lkrehi 4361 3 poisoning poisoning NN cord-335975-m6lkrehi 4361 4 is be VBZ cord-335975-m6lkrehi 4361 5 defined define VBN cord-335975-m6lkrehi 4361 6 by by IN cord-335975-m6lkrehi 4361 7 the the DT cord-335975-m6lkrehi 4361 8 need need NN cord-335975-m6lkrehi 4361 9 for for IN cord-335975-m6lkrehi 4361 10 intensive intensive JJ cord-335975-m6lkrehi 4361 11 care care NN cord-335975-m6lkrehi 4361 12 monitoring monitoring NN cord-335975-m6lkrehi 4361 13 due due IN cord-335975-m6lkrehi 4361 14 to to IN cord-335975-m6lkrehi 4361 15 the the DT cord-335975-m6lkrehi 4361 16 nature nature NN cord-335975-m6lkrehi 4361 17 , , , cord-335975-m6lkrehi 4361 18 quantity quantity NN cord-335975-m6lkrehi 4361 19 of of IN cord-335975-m6lkrehi 4361 20 the the DT cord-335975-m6lkrehi 4361 21 substance substance NN cord-335975-m6lkrehi 4361 22 and and CC cord-335975-m6lkrehi 4361 23 or or CC cord-335975-m6lkrehi 4361 24 clinical clinical JJ cord-335975-m6lkrehi 4361 25 manifestations manifestation NNS cord-335975-m6lkrehi 4361 26 . . . cord-335975-m6lkrehi 4362 1 It -PRON- PRP cord-335975-m6lkrehi 4362 2 is be VBZ cord-335975-m6lkrehi 4362 3 one one CD cord-335975-m6lkrehi 4362 4 of of IN cord-335975-m6lkrehi 4362 5 the the DT cord-335975-m6lkrehi 4362 6 frequent frequent JJ cord-335975-m6lkrehi 4362 7 reasons reason NNS cord-335975-m6lkrehi 4362 8 for for IN cord-335975-m6lkrehi 4362 9 admission admission NN cord-335975-m6lkrehi 4362 10 to to IN cord-335975-m6lkrehi 4362 11 emergency emergency NN cord-335975-m6lkrehi 4362 12 and and CC cord-335975-m6lkrehi 4362 13 resuscitation resuscitation NN cord-335975-m6lkrehi 4362 14 . . . cord-335975-m6lkrehi 4363 1 The the DT cord-335975-m6lkrehi 4363 2 purpose purpose NN cord-335975-m6lkrehi 4363 3 of of IN cord-335975-m6lkrehi 4363 4 this this DT cord-335975-m6lkrehi 4363 5 work work NN cord-335975-m6lkrehi 4363 6 is be VBZ cord-335975-m6lkrehi 4363 7 to to TO cord-335975-m6lkrehi 4363 8 identify identify VB cord-335975-m6lkrehi 4363 9 poisoning poisoning NN cord-335975-m6lkrehi 4363 10 in in IN cord-335975-m6lkrehi 4363 11 children child NNS cord-335975-m6lkrehi 4363 12 admitted admit VBN cord-335975-m6lkrehi 4363 13 to to IN cord-335975-m6lkrehi 4363 14 pediatric pediatric JJ cord-335975-m6lkrehi 4363 15 intensive intensive JJ cord-335975-m6lkrehi 4363 16 care care NN cord-335975-m6lkrehi 4363 17 units unit NNS cord-335975-m6lkrehi 4363 18 in in IN cord-335975-m6lkrehi 4363 19 order order NN cord-335975-m6lkrehi 4363 20 to to TO cord-335975-m6lkrehi 4363 21 assess assess VB cord-335975-m6lkrehi 4363 22 the the DT cord-335975-m6lkrehi 4363 23 frequency frequency NN cord-335975-m6lkrehi 4363 24 , , , cord-335975-m6lkrehi 4363 25 identify identify VB cord-335975-m6lkrehi 4363 26 the the DT cord-335975-m6lkrehi 4363 27 products product NNS cord-335975-m6lkrehi 4363 28 involved involve VBN cord-335975-m6lkrehi 4363 29 , , , cord-335975-m6lkrehi 4363 30 and and CC cord-335975-m6lkrehi 4363 31 the the DT cord-335975-m6lkrehi 4363 32 clinical clinical JJ cord-335975-m6lkrehi 4363 33 and and CC cord-335975-m6lkrehi 4363 34 evolutionary evolutionary JJ cord-335975-m6lkrehi 4363 35 aspects aspect NNS cord-335975-m6lkrehi 4363 36 . . . cord-335975-m6lkrehi 4364 1 Patients patient NNS cord-335975-m6lkrehi 4364 2 and and CC cord-335975-m6lkrehi 4364 3 methods method NNS cord-335975-m6lkrehi 4364 4 : : : cord-335975-m6lkrehi 4364 5 This this DT cord-335975-m6lkrehi 4364 6 is be VBZ cord-335975-m6lkrehi 4364 7 a a DT cord-335975-m6lkrehi 4364 8 descriptive descriptive JJ cord-335975-m6lkrehi 4364 9 study study NN cord-335975-m6lkrehi 4364 10 over over IN cord-335975-m6lkrehi 4364 11 a a DT cord-335975-m6lkrehi 4364 12 24-month 24-month JJ cord-335975-m6lkrehi 4364 13 period period NN cord-335975-m6lkrehi 4364 14 in in IN cord-335975-m6lkrehi 4364 15 the the DT cord-335975-m6lkrehi 4364 16 Canastel Canastel NNP cord-335975-m6lkrehi 4364 17 Oran Oran NNP cord-335975-m6lkrehi 4364 18 multi multi JJ cord-335975-m6lkrehi 4364 19 - - JJ cord-335975-m6lkrehi 4364 20 purpose purpose JJ cord-335975-m6lkrehi 4364 21 pediatric pediatric JJ cord-335975-m6lkrehi 4364 22 intensive intensive JJ cord-335975-m6lkrehi 4364 23 care care NN cord-335975-m6lkrehi 4364 24 unit unit NN cord-335975-m6lkrehi 4364 25 from from IN cord-335975-m6lkrehi 4364 26 July July NNP cord-335975-m6lkrehi 4364 27 2016 2016 CD cord-335975-m6lkrehi 4364 28 to to IN cord-335975-m6lkrehi 4364 29 July July NNP cord-335975-m6lkrehi 4364 30 2017 2017 CD cord-335975-m6lkrehi 4364 31 . . . cord-335975-m6lkrehi 4365 1 We -PRON- PRP cord-335975-m6lkrehi 4365 2 included include VBD cord-335975-m6lkrehi 4365 3 all all DT cord-335975-m6lkrehi 4365 4 children child NNS cord-335975-m6lkrehi 4365 5 aged aged JJ cord-335975-m6lkrehi 4365 6 0 0 CD cord-335975-m6lkrehi 4365 7 - - SYM cord-335975-m6lkrehi 4365 8 15 15 CD cord-335975-m6lkrehi 4365 9 years year NNS cord-335975-m6lkrehi 4365 10 admitted admit VBN cord-335975-m6lkrehi 4365 11 for for IN cord-335975-m6lkrehi 4365 12 ingestion ingestion NN cord-335975-m6lkrehi 4365 13 and and CC cord-335975-m6lkrehi 4365 14 inhalation inhalation NN cord-335975-m6lkrehi 4365 15 of of IN cord-335975-m6lkrehi 4365 16 products product NNS cord-335975-m6lkrehi 4365 17 toxic toxic JJ cord-335975-m6lkrehi 4365 18 . . . cord-335975-m6lkrehi 4366 1 Results result NNS cord-335975-m6lkrehi 4366 2 : : : cord-335975-m6lkrehi 4367 1 39 39 CD cord-335975-m6lkrehi 4367 2 children child NNS cord-335975-m6lkrehi 4367 3 admitted admit VBD cord-335975-m6lkrehi 4367 4 to to IN cord-335975-m6lkrehi 4367 5 pediatric pediatric JJ cord-335975-m6lkrehi 4367 6 intensive intensive JJ cord-335975-m6lkrehi 4367 7 care care NN cord-335975-m6lkrehi 4367 8 , , , cord-335975-m6lkrehi 4367 9 mean mean JJ cord-335975-m6lkrehi 4367 10 age age NN cord-335975-m6lkrehi 4367 11 was be VBD cord-335975-m6lkrehi 4367 12 5 5 CD cord-335975-m6lkrehi 4367 13 years year NNS cord-335975-m6lkrehi 4367 14 , , , cord-335975-m6lkrehi 4367 15 70 70 CD cord-335975-m6lkrehi 4367 16 % % NN cord-335975-m6lkrehi 4367 17 under under IN cord-335975-m6lkrehi 4367 18 6 6 CD cord-335975-m6lkrehi 4367 19 years year NNS cord-335975-m6lkrehi 4367 20 with with IN cord-335975-m6lkrehi 4367 21 extremes extreme NNS cord-335975-m6lkrehi 4367 22 of of IN cord-335975-m6lkrehi 4367 23 02 02 CD cord-335975-m6lkrehi 4367 24 months month NNS cord-335975-m6lkrehi 4367 25 and and CC cord-335975-m6lkrehi 4367 26 15 15 CD cord-335975-m6lkrehi 4367 27 years year NNS cord-335975-m6lkrehi 4367 28 , , , cord-335975-m6lkrehi 4367 29 a a DT cord-335975-m6lkrehi 4367 30 female female JJ cord-335975-m6lkrehi 4367 31 predominance predominance NN cord-335975-m6lkrehi 4367 32 of of IN cord-335975-m6lkrehi 4367 33 60 60 CD cord-335975-m6lkrehi 4367 34 % % NN cord-335975-m6lkrehi 4367 35 was be VBD cord-335975-m6lkrehi 4367 36 observed observe VBN cord-335975-m6lkrehi 4367 37 with with IN cord-335975-m6lkrehi 4367 38 a a DT cord-335975-m6lkrehi 4367 39 slight slight JJ cord-335975-m6lkrehi 4367 40 predominance predominance NN cord-335975-m6lkrehi 4367 41 of of IN cord-335975-m6lkrehi 4367 42 accidental accidental JJ cord-335975-m6lkrehi 4367 43 poisoning poisoning NN cord-335975-m6lkrehi 4367 44 ( ( -LRB- cord-335975-m6lkrehi 4367 45 56 56 CD cord-335975-m6lkrehi 4367 46 % % NN cord-335975-m6lkrehi 4367 47 ) ) -RRB- cord-335975-m6lkrehi 4368 1 Compared compare VBN cord-335975-m6lkrehi 4368 2 to to IN cord-335975-m6lkrehi 4368 3 voluntary voluntary JJ cord-335975-m6lkrehi 4368 4 poisoning poisoning NN cord-335975-m6lkrehi 4368 5 ( ( -LRB- cord-335975-m6lkrehi 4368 6 44 44 CD cord-335975-m6lkrehi 4368 7 % % NN cord-335975-m6lkrehi 4368 8 ) ) -RRB- cord-335975-m6lkrehi 4368 9 . . . cord-335975-m6lkrehi 4369 1 In in IN cord-335975-m6lkrehi 4369 2 87 87 CD cord-335975-m6lkrehi 4369 3 % % NN cord-335975-m6lkrehi 4369 4 the the DT cord-335975-m6lkrehi 4369 5 toxic toxic JJ cord-335975-m6lkrehi 4369 6 is be VBZ cord-335975-m6lkrehi 4369 7 ingested ingest VBN cord-335975-m6lkrehi 4369 8 orally orally RB cord-335975-m6lkrehi 4369 9 . . . cord-335975-m6lkrehi 4370 1 The the DT cord-335975-m6lkrehi 4370 2 most most RBS cord-335975-m6lkrehi 4370 3 frequent frequent JJ cord-335975-m6lkrehi 4370 4 toxicants toxicant NNS cord-335975-m6lkrehi 4370 5 were be VBD cord-335975-m6lkrehi 4370 6 drugs drug NNS cord-335975-m6lkrehi 4370 7 with with IN cord-335975-m6lkrehi 4370 8 19 19 CD cord-335975-m6lkrehi 4370 9 cases case NNS cord-335975-m6lkrehi 4370 10 ( ( -LRB- cord-335975-m6lkrehi 4370 11 35 35 CD cord-335975-m6lkrehi 4370 12 % % NN cord-335975-m6lkrehi 4370 13 ) ) -RRB- cord-335975-m6lkrehi 4370 14 , , , cord-335975-m6lkrehi 4370 15 mostly mostly RB cord-335975-m6lkrehi 4370 16 antidepressants antidepressant NNS cord-335975-m6lkrehi 4370 17 and and CC cord-335975-m6lkrehi 4370 18 antiepileptics antiepileptic NNS cord-335975-m6lkrehi 4370 19 , , , cord-335975-m6lkrehi 4370 20 followed follow VBN cord-335975-m6lkrehi 4370 21 by by IN cord-335975-m6lkrehi 4370 22 organophosphates organophosphate NNS cord-335975-m6lkrehi 4370 23 with with IN cord-335975-m6lkrehi 4370 24 10 10 CD cord-335975-m6lkrehi 4370 25 cases case NNS cord-335975-m6lkrehi 4370 26 ( ( -LRB- cord-335975-m6lkrehi 4370 27 26 26 CD cord-335975-m6lkrehi 4370 28 % % NN cord-335975-m6lkrehi 4370 29 ) ) -RRB- cord-335975-m6lkrehi 4370 30 , , , cord-335975-m6lkrehi 4370 31 CO CO NNP cord-335975-m6lkrehi 4370 32 5 5 CD cord-335975-m6lkrehi 4370 33 cases case NNS cord-335975-m6lkrehi 4370 34 ( ( -LRB- cord-335975-m6lkrehi 4370 35 12 12 CD cord-335975-m6lkrehi 4370 36 % % NN cord-335975-m6lkrehi 4370 37 ) ) -RRB- cord-335975-m6lkrehi 4370 38 , , , cord-335975-m6lkrehi 4370 39 petroleum petroleum NN cord-335975-m6lkrehi 4370 40 products product NNS cord-335975-m6lkrehi 4370 41 and and CC cord-335975-m6lkrehi 4370 42 plants plant NNS cord-335975-m6lkrehi 4370 43 with with IN cord-335975-m6lkrehi 4370 44 5 5 CD cord-335975-m6lkrehi 4370 45 cases case NNS cord-335975-m6lkrehi 4370 46 ( ( -LRB- cord-335975-m6lkrehi 4370 47 12 12 CD cord-335975-m6lkrehi 4370 48 % % NN cord-335975-m6lkrehi 4370 49 ) ) -RRB- cord-335975-m6lkrehi 4370 50 . . . cord-335975-m6lkrehi 4371 1 The the DT cord-335975-m6lkrehi 4371 2 main main JJ cord-335975-m6lkrehi 4371 3 clinical clinical JJ cord-335975-m6lkrehi 4371 4 signs sign NNS cord-335975-m6lkrehi 4371 5 were be VBD cord-335975-m6lkrehi 4371 6 neurological neurological JJ cord-335975-m6lkrehi 4371 7 signs sign NNS cord-335975-m6lkrehi 4371 8 ( ( -LRB- cord-335975-m6lkrehi 4371 9 76 76 CD cord-335975-m6lkrehi 4371 10 % % NN cord-335975-m6lkrehi 4371 11 ) ) -RRB- cord-335975-m6lkrehi 4371 12 with with IN cord-335975-m6lkrehi 4371 13 predominance predominance NN cord-335975-m6lkrehi 4371 14 of of IN cord-335975-m6lkrehi 4371 15 coma coma NN cord-335975-m6lkrehi 4371 16 and and CC cord-335975-m6lkrehi 4371 17 convulsions convulsion NNS cord-335975-m6lkrehi 4371 18 in in IN cord-335975-m6lkrehi 4371 19 19 19 CD cord-335975-m6lkrehi 4371 20 cases case NNS cord-335975-m6lkrehi 4371 21 ( ( -LRB- cord-335975-m6lkrehi 4371 22 43 43 CD cord-335975-m6lkrehi 4371 23 % % NN cord-335975-m6lkrehi 4371 24 ) ) -RRB- cord-335975-m6lkrehi 4371 25 , , , cord-335975-m6lkrehi 4371 26 respiratory respiratory JJ cord-335975-m6lkrehi 4371 27 distress distress NN cord-335975-m6lkrehi 4371 28 was be VBD cord-335975-m6lkrehi 4371 29 present present JJ cord-335975-m6lkrehi 4371 30 in in IN cord-335975-m6lkrehi 4371 31 6 6 CD cord-335975-m6lkrehi 4371 32 cases case NNS cord-335975-m6lkrehi 4371 33 ( ( -LRB- cord-335975-m6lkrehi 4371 34 15 15 CD cord-335975-m6lkrehi 4371 35 % % NN cord-335975-m6lkrehi 4371 36 ) ) -RRB- cord-335975-m6lkrehi 4371 37 and and CC cord-335975-m6lkrehi 4371 38 digestive digestive JJ cord-335975-m6lkrehi 4371 39 signs sign NNS cord-335975-m6lkrehi 4371 40 8 8 CD cord-335975-m6lkrehi 4371 41 cases case NNS cord-335975-m6lkrehi 4371 42 ( ( -LRB- cord-335975-m6lkrehi 4371 43 20 20 CD cord-335975-m6lkrehi 4371 44 % % NN cord-335975-m6lkrehi 4371 45 ) ) -RRB- cord-335975-m6lkrehi 4371 46 . . . cord-335975-m6lkrehi 4372 1 For for IN cord-335975-m6lkrehi 4372 2 therapeutic therapeutic JJ cord-335975-m6lkrehi 4372 3 management management NN cord-335975-m6lkrehi 4372 4 gastric gastric NN cord-335975-m6lkrehi 4372 5 lavage lavage NN cord-335975-m6lkrehi 4372 6 , , , cord-335975-m6lkrehi 4372 7 charcoal charcoal NN cord-335975-m6lkrehi 4372 8 and and CC cord-335975-m6lkrehi 4372 9 antidotes antidote NNS cord-335975-m6lkrehi 4372 10 were be VBD cord-335975-m6lkrehi 4372 11 the the DT cord-335975-m6lkrehi 4372 12 most most RBS cord-335975-m6lkrehi 4372 13 frequent frequent JJ cord-335975-m6lkrehi 4372 14 treatments treatment NNS cord-335975-m6lkrehi 4372 15 . . . cord-335975-m6lkrehi 4373 1 The the DT cord-335975-m6lkrehi 4373 2 evolution evolution NN cord-335975-m6lkrehi 4373 3 was be VBD cord-335975-m6lkrehi 4373 4 marked mark VBN cord-335975-m6lkrehi 4373 5 by by IN cord-335975-m6lkrehi 4373 6 a a DT cord-335975-m6lkrehi 4373 7 mortality mortality NN cord-335975-m6lkrehi 4373 8 of of IN cord-335975-m6lkrehi 4373 9 2 2 CD cord-335975-m6lkrehi 4373 10 % % NN cord-335975-m6lkrehi 4373 11 or or CC cord-335975-m6lkrehi 4373 12 a a DT cord-335975-m6lkrehi 4373 13 death death NN cord-335975-m6lkrehi 4373 14 secondary secondary JJ cord-335975-m6lkrehi 4373 15 to to IN cord-335975-m6lkrehi 4373 16 a a DT cord-335975-m6lkrehi 4373 17 poly poly JJ cord-335975-m6lkrehi 4373 18 - - HYPH cord-335975-m6lkrehi 4373 19 medicinal medicinal JJ cord-335975-m6lkrehi 4373 20 intoxication intoxication NN cord-335975-m6lkrehi 4373 21 voluntary voluntary JJ cord-335975-m6lkrehi 4373 22 in in IN cord-335975-m6lkrehi 4373 23 a a DT cord-335975-m6lkrehi 4373 24 girl girl NN cord-335975-m6lkrehi 4373 25 of of IN cord-335975-m6lkrehi 4373 26 10 10 CD cord-335975-m6lkrehi 4373 27 years year NNS cord-335975-m6lkrehi 4373 28 . . . cord-335975-m6lkrehi 4374 1 Mechanical mechanical JJ cord-335975-m6lkrehi 4374 2 ventilation ventilation NN cord-335975-m6lkrehi 4374 3 in in IN cord-335975-m6lkrehi 4374 4 5 5 CD cord-335975-m6lkrehi 4374 5 cases case NNS cord-335975-m6lkrehi 4374 6 ( ( -LRB- cord-335975-m6lkrehi 4374 7 12 12 CD cord-335975-m6lkrehi 4374 8 % % NN cord-335975-m6lkrehi 4374 9 ) ) -RRB- cord-335975-m6lkrehi 4374 10 and and CC cord-335975-m6lkrehi 4374 11 an an DT cord-335975-m6lkrehi 4374 12 average average JJ cord-335975-m6lkrehi 4374 13 hospital hospital NN cord-335975-m6lkrehi 4374 14 stay stay NN cord-335975-m6lkrehi 4374 15 of of IN cord-335975-m6lkrehi 4374 16 2 2 CD cord-335975-m6lkrehi 4374 17 days day NNS cord-335975-m6lkrehi 4374 18 . . . cord-335975-m6lkrehi 4375 1 Conclusion conclusion NN cord-335975-m6lkrehi 4375 2 : : : cord-335975-m6lkrehi 4376 1 Acute acute JJ cord-335975-m6lkrehi 4376 2 poisoning poisoning NN cord-335975-m6lkrehi 4376 3 is be VBZ cord-335975-m6lkrehi 4376 4 a a DT cord-335975-m6lkrehi 4376 5 medical medical JJ cord-335975-m6lkrehi 4376 6 emergency emergency NN cord-335975-m6lkrehi 4376 7 that that WDT cord-335975-m6lkrehi 4376 8 may may MD cord-335975-m6lkrehi 4376 9 require require VB cord-335975-m6lkrehi 4376 10 resuscitation resuscitation NN cord-335975-m6lkrehi 4376 11 . . . cord-335975-m6lkrehi 4377 1 Young young JJ cord-335975-m6lkrehi 4377 2 children child NNS cord-335975-m6lkrehi 4377 3 are be VBP cord-335975-m6lkrehi 4377 4 most most RBS cord-335975-m6lkrehi 4377 5 exposed expose VBN cord-335975-m6lkrehi 4377 6 with with IN cord-335975-m6lkrehi 4377 7 drugs drug NNS cord-335975-m6lkrehi 4377 8 are be VBP cord-335975-m6lkrehi 4377 9 the the DT cord-335975-m6lkrehi 4377 10 most most RBS cord-335975-m6lkrehi 4377 11 frequently frequently RB cord-335975-m6lkrehi 4377 12 incriminated incriminate VBN cord-335975-m6lkrehi 4377 13 . . . cord-335975-m6lkrehi 4378 1 We -PRON- PRP cord-335975-m6lkrehi 4378 2 propose propose VBP cord-335975-m6lkrehi 4378 3 , , , cord-335975-m6lkrehi 4378 4 as as IN cord-335975-m6lkrehi 4378 5 a a DT cord-335975-m6lkrehi 4378 6 preventive preventive JJ cord-335975-m6lkrehi 4378 7 measure measure NN cord-335975-m6lkrehi 4378 8 , , , cord-335975-m6lkrehi 4378 9 companions companion NNS cord-335975-m6lkrehi 4378 10 of of IN cord-335975-m6lkrehi 4378 11 information information NN cord-335975-m6lkrehi 4378 12 on on IN cord-335975-m6lkrehi 4378 13 the the DT cord-335975-m6lkrehi 4378 14 dangers danger NNS cord-335975-m6lkrehi 4378 15 of of IN cord-335975-m6lkrehi 4378 16 toxic toxic JJ cord-335975-m6lkrehi 4378 17 products product NNS cord-335975-m6lkrehi 4378 18 and and CC cord-335975-m6lkrehi 4378 19 especially especially RB cord-335975-m6lkrehi 4378 20 of of IN cord-335975-m6lkrehi 4378 21 medicines medicine NNS cord-335975-m6lkrehi 4378 22 by by IN cord-335975-m6lkrehi 4378 23 the the DT cord-335975-m6lkrehi 4378 24 surveillance surveillance NN cord-335975-m6lkrehi 4378 25 of of IN cord-335975-m6lkrehi 4378 26 the the DT cord-335975-m6lkrehi 4378 27 child child NN cord-335975-m6lkrehi 4378 28 and and CC cord-335975-m6lkrehi 4378 29 the the DT cord-335975-m6lkrehi 4378 30 regulation regulation NN cord-335975-m6lkrehi 4378 31 of of IN cord-335975-m6lkrehi 4378 32 certain certain JJ cord-335975-m6lkrehi 4378 33 products product NNS cord-335975-m6lkrehi 4378 34 . . . cord-335975-m6lkrehi 4379 1 Introduction introduction NN cord-335975-m6lkrehi 4379 2 : : : cord-335975-m6lkrehi 4380 1 The the DT cord-335975-m6lkrehi 4380 2 place place NN cord-335975-m6lkrehi 4380 3 of of IN cord-335975-m6lkrehi 4380 4 neuron neuron NN cord-335975-m6lkrehi 4380 5 specific specific JJ cord-335975-m6lkrehi 4380 6 enolase enolase NN cord-335975-m6lkrehi 4380 7 ( ( -LRB- cord-335975-m6lkrehi 4380 8 NSE NSE NNP cord-335975-m6lkrehi 4380 9 ) ) -RRB- cord-335975-m6lkrehi 4380 10 dosing dosing NN cord-335975-m6lkrehi 4380 11 remains remain VBZ cord-335975-m6lkrehi 4380 12 uncertain uncertain JJ cord-335975-m6lkrehi 4380 13 as as IN cord-335975-m6lkrehi 4380 14 an an DT cord-335975-m6lkrehi 4380 15 indicator indicator NN cord-335975-m6lkrehi 4380 16 of of IN cord-335975-m6lkrehi 4380 17 neurological neurological JJ cord-335975-m6lkrehi 4380 18 prognosis prognosis NN cord-335975-m6lkrehi 4380 19 after after IN cord-335975-m6lkrehi 4380 20 a a DT cord-335975-m6lkrehi 4380 21 cardiac cardiac JJ cord-335975-m6lkrehi 4380 22 arrest arrest NN cord-335975-m6lkrehi 4380 23 , , , cord-335975-m6lkrehi 4380 24 the the DT cord-335975-m6lkrehi 4380 25 threshold threshold NN cord-335975-m6lkrehi 4380 26 value value NN cord-335975-m6lkrehi 4380 27 for for IN cord-335975-m6lkrehi 4380 28 predicting predict VBG cord-335975-m6lkrehi 4380 29 an an DT cord-335975-m6lkrehi 4380 30 unfavorable unfavorable JJ cord-335975-m6lkrehi 4380 31 evolution evolution NN cord-335975-m6lkrehi 4380 32 being be VBG cord-335975-m6lkrehi 4380 33 variable variable JJ cord-335975-m6lkrehi 4380 34 from from IN cord-335975-m6lkrehi 4380 35 one one CD cord-335975-m6lkrehi 4380 36 study study NN cord-335975-m6lkrehi 4380 37 to to IN cord-335975-m6lkrehi 4380 38 another another DT cord-335975-m6lkrehi 4380 39 . . . cord-335975-m6lkrehi 4381 1 Our -PRON- PRP$ cord-335975-m6lkrehi 4381 2 objective objective NN cord-335975-m6lkrehi 4381 3 was be VBD cord-335975-m6lkrehi 4381 4 to to TO cord-335975-m6lkrehi 4381 5 determine determine VB cord-335975-m6lkrehi 4381 6 a a DT cord-335975-m6lkrehi 4381 7 NSE NSE NNP cord-335975-m6lkrehi 4381 8 cut cut VBN cord-335975-m6lkrehi 4381 9 - - HYPH cord-335975-m6lkrehi 4381 10 off off RP cord-335975-m6lkrehi 4381 11 value value NN cord-335975-m6lkrehi 4381 12 predictive predictive JJ cord-335975-m6lkrehi 4381 13 of of IN cord-335975-m6lkrehi 4381 14 poor poor JJ cord-335975-m6lkrehi 4381 15 neurological neurological JJ cord-335975-m6lkrehi 4381 16 outcome outcome NN cord-335975-m6lkrehi 4381 17 after after IN cord-335975-m6lkrehi 4381 18 a a DT cord-335975-m6lkrehi 4381 19 cardiac cardiac JJ cord-335975-m6lkrehi 4381 20 arrest arrest NN cord-335975-m6lkrehi 4381 21 . . . cord-335975-m6lkrehi 4382 1 Patients patient NNS cord-335975-m6lkrehi 4382 2 and and CC cord-335975-m6lkrehi 4382 3 methods method NNS cord-335975-m6lkrehi 4383 1 : : : cord-335975-m6lkrehi 4383 2 We -PRON- PRP cord-335975-m6lkrehi 4383 3 realized realize VBD cord-335975-m6lkrehi 4383 4 a a DT cord-335975-m6lkrehi 4383 5 monocentric monocentric JJ cord-335975-m6lkrehi 4383 6 prospective prospective JJ cord-335975-m6lkrehi 4383 7 trial trial NN cord-335975-m6lkrehi 4383 8 in in IN cord-335975-m6lkrehi 4383 9 a a DT cord-335975-m6lkrehi 4383 10 medical medical JJ cord-335975-m6lkrehi 4383 11 ICU ICU NNP cord-335975-m6lkrehi 4383 12 of of IN cord-335975-m6lkrehi 4383 13 a a DT cord-335975-m6lkrehi 4383 14 French French NNP cord-335975-m6lkrehi 4383 15 University University NNP cord-335975-m6lkrehi 4383 16 hospital hospital NN cord-335975-m6lkrehi 4383 17 from from IN cord-335975-m6lkrehi 4383 18 January January NNP cord-335975-m6lkrehi 4383 19 1st 1st NN cord-335975-m6lkrehi 4383 20 2016 2016 CD cord-335975-m6lkrehi 4383 21 to to IN cord-335975-m6lkrehi 4383 22 December December NNP cord-335975-m6lkrehi 4383 23 31th 31th NN cord-335975-m6lkrehi 4383 24 2016 2016 CD cord-335975-m6lkrehi 4383 25 . . . cord-335975-m6lkrehi 4384 1 All all DT cord-335975-m6lkrehi 4384 2 patients patient NNS cord-335975-m6lkrehi 4384 3 over over IN cord-335975-m6lkrehi 4384 4 18 18 CD cord-335975-m6lkrehi 4384 5 years year NNS cord-335975-m6lkrehi 4384 6 old old JJ cord-335975-m6lkrehi 4384 7 hospitalized hospitalize VBD cord-335975-m6lkrehi 4384 8 for for IN cord-335975-m6lkrehi 4384 9 a a DT cord-335975-m6lkrehi 4384 10 cardiac cardiac JJ cord-335975-m6lkrehi 4384 11 arrest arrest NN cord-335975-m6lkrehi 4384 12 in in IN cord-335975-m6lkrehi 4384 13 medical medical JJ cord-335975-m6lkrehi 4384 14 ICU ICU NNP cord-335975-m6lkrehi 4384 15 were be VBD cord-335975-m6lkrehi 4384 16 included include VBN cord-335975-m6lkrehi 4384 17 . . . cord-335975-m6lkrehi 4385 1 Patients patient NNS cord-335975-m6lkrehi 4385 2 who who WP cord-335975-m6lkrehi 4385 3 died die VBD cord-335975-m6lkrehi 4385 4 during during IN cord-335975-m6lkrehi 4385 5 the the DT cord-335975-m6lkrehi 4385 6 first first JJ cord-335975-m6lkrehi 4385 7 24 24 CD cord-335975-m6lkrehi 4385 8 h h NN cord-335975-m6lkrehi 4385 9 or or CC cord-335975-m6lkrehi 4385 10 admitted admit VBN cord-335975-m6lkrehi 4385 11 for for IN cord-335975-m6lkrehi 4385 12 cardiac cardiac JJ cord-335975-m6lkrehi 4385 13 arrest arrest NN cord-335975-m6lkrehi 4385 14 with with IN cord-335975-m6lkrehi 4385 15 a a DT cord-335975-m6lkrehi 4385 16 neurological neurological JJ cord-335975-m6lkrehi 4385 17 cause cause NN cord-335975-m6lkrehi 4385 18 were be VBD cord-335975-m6lkrehi 4385 19 excluded exclude VBN cord-335975-m6lkrehi 4385 20 . . . cord-335975-m6lkrehi 4386 1 Serum serum NN cord-335975-m6lkrehi 4386 2 NSE nse NN cord-335975-m6lkrehi 4386 3 values value NNS cord-335975-m6lkrehi 4386 4 ( ( -LRB- cord-335975-m6lkrehi 4386 5 Elecsys Elecsys NNP cord-335975-m6lkrehi 4386 6 NSE NSE NNP cord-335975-m6lkrehi 4386 7 test test NN cord-335975-m6lkrehi 4386 8 , , , cord-335975-m6lkrehi 4386 9 Cobas Cobas NNP cord-335975-m6lkrehi 4386 10 ® ® POS cord-335975-m6lkrehi 4386 11 analyzer analyzer NN cord-335975-m6lkrehi 4386 12 ) ) -RRB- cord-335975-m6lkrehi 4386 13 were be VBD cord-335975-m6lkrehi 4386 14 assessed assess VBN cord-335975-m6lkrehi 4386 15 at at IN cord-335975-m6lkrehi 4386 16 H24 H24 NNP cord-335975-m6lkrehi 4386 17 and and CC cord-335975-m6lkrehi 4386 18 H72 H72 NNP cord-335975-m6lkrehi 4386 19 after after IN cord-335975-m6lkrehi 4386 20 cardiac cardiac JJ cord-335975-m6lkrehi 4386 21 arrest arrest NN cord-335975-m6lkrehi 4386 22 . . . cord-335975-m6lkrehi 4387 1 Somatosensory somatosensory NN cord-335975-m6lkrehi 4387 2 evoked evoke VBD cord-335975-m6lkrehi 4387 3 potentials potential NNS cord-335975-m6lkrehi 4387 4 were be VBD cord-335975-m6lkrehi 4387 5 recorded record VBN cord-335975-m6lkrehi 4387 6 between between IN cord-335975-m6lkrehi 4387 7 H24 H24 NNP cord-335975-m6lkrehi 4387 8 and and CC cord-335975-m6lkrehi 4387 9 H72 H72 NNP cord-335975-m6lkrehi 4387 10 . . . cord-335975-m6lkrehi 4388 1 The the DT cord-335975-m6lkrehi 4388 2 primary primary JJ cord-335975-m6lkrehi 4388 3 endpoint endpoint NN cord-335975-m6lkrehi 4388 4 was be VBD cord-335975-m6lkrehi 4388 5 neurological neurological JJ cord-335975-m6lkrehi 4388 6 outcome outcome NN cord-335975-m6lkrehi 4388 7 at at IN cord-335975-m6lkrehi 4388 8 6 6 CD cord-335975-m6lkrehi 4388 9 month month NN cord-335975-m6lkrehi 4388 10 using use VBG cord-335975-m6lkrehi 4388 11 the the DT cord-335975-m6lkrehi 4388 12 cerebral cerebral JJ cord-335975-m6lkrehi 4388 13 performance performance NN cord-335975-m6lkrehi 4388 14 category category NN cord-335975-m6lkrehi 4388 15 scale scale NN cord-335975-m6lkrehi 4388 16 ( ( -LRB- cord-335975-m6lkrehi 4388 17 CPCS CPCS NNP cord-335975-m6lkrehi 4388 18 ) ) -RRB- cord-335975-m6lkrehi 4388 19 . . . cord-335975-m6lkrehi 4389 1 CPCS CPCS NNP cord-335975-m6lkrehi 4389 2 1 1 CD cord-335975-m6lkrehi 4389 3 or or CC cord-335975-m6lkrehi 4389 4 2 2 CD cord-335975-m6lkrehi 4389 5 was be VBD cord-335975-m6lkrehi 4389 6 considered consider VBN cord-335975-m6lkrehi 4389 7 as as IN cord-335975-m6lkrehi 4389 8 favorable favorable JJ cord-335975-m6lkrehi 4389 9 outcome outcome NN cord-335975-m6lkrehi 4389 10 and and CC cord-335975-m6lkrehi 4389 11 CPCS CPCS NNP cord-335975-m6lkrehi 4389 12 higher high JJR cord-335975-m6lkrehi 4389 13 than than IN cord-335975-m6lkrehi 4389 14 2 2 CD cord-335975-m6lkrehi 4389 15 as as IN cord-335975-m6lkrehi 4389 16 poor poor JJ cord-335975-m6lkrehi 4389 17 outcome outcome NN cord-335975-m6lkrehi 4389 18 . . . cord-335975-m6lkrehi 4390 1 Data datum NNS cord-335975-m6lkrehi 4390 2 were be VBD cord-335975-m6lkrehi 4390 3 collected collect VBN cord-335975-m6lkrehi 4390 4 using use VBG cord-335975-m6lkrehi 4390 5 cardiologic cardiologic JJ cord-335975-m6lkrehi 4390 6 or or CC cord-335975-m6lkrehi 4390 7 neurologic neurologic JJ cord-335975-m6lkrehi 4390 8 consultations consultation NNS cord-335975-m6lkrehi 4390 9 report report VBP cord-335975-m6lkrehi 4390 10 , , , cord-335975-m6lkrehi 4390 11 or or CC cord-335975-m6lkrehi 4390 12 by by IN cord-335975-m6lkrehi 4390 13 phone phone NN cord-335975-m6lkrehi 4390 14 call call NN cord-335975-m6lkrehi 4390 15 to to IN cord-335975-m6lkrehi 4390 16 the the DT cord-335975-m6lkrehi 4390 17 patient patient NN cord-335975-m6lkrehi 4390 18 . . . cord-335975-m6lkrehi 4391 1 Using use VBG cord-335975-m6lkrehi 4391 2 a a DT cord-335975-m6lkrehi 4391 3 ROC ROC NNP cord-335975-m6lkrehi 4391 4 curve curve NN cord-335975-m6lkrehi 4391 5 we -PRON- PRP cord-335975-m6lkrehi 4391 6 determined determine VBD cord-335975-m6lkrehi 4391 7 the the DT cord-335975-m6lkrehi 4391 8 NSE NSE NNP cord-335975-m6lkrehi 4391 9 value value NN cord-335975-m6lkrehi 4391 10 at at IN cord-335975-m6lkrehi 4391 11 H24 H24 NNP cord-335975-m6lkrehi 4391 12 with with IN cord-335975-m6lkrehi 4391 13 higher high JJR cord-335975-m6lkrehi 4391 14 specificity specificity NN cord-335975-m6lkrehi 4391 15 and and CC cord-335975-m6lkrehi 4391 16 acceptable acceptable JJ cord-335975-m6lkrehi 4391 17 sensitivity sensitivity NN cord-335975-m6lkrehi 4391 18 . . . cord-335975-m6lkrehi 4392 1 Results result NNS cord-335975-m6lkrehi 4392 2 : : : cord-335975-m6lkrehi 4392 3 We -PRON- PRP cord-335975-m6lkrehi 4392 4 included include VBD cord-335975-m6lkrehi 4392 5 48 48 CD cord-335975-m6lkrehi 4392 6 patients patient NNS cord-335975-m6lkrehi 4392 7 . . . cord-335975-m6lkrehi 4393 1 Average average JJ cord-335975-m6lkrehi 4393 2 age age NN cord-335975-m6lkrehi 4393 3 was be VBD cord-335975-m6lkrehi 4393 4 62 62 CD cord-335975-m6lkrehi 4393 5 years year NNS cord-335975-m6lkrehi 4393 6 old old JJ cord-335975-m6lkrehi 4393 7 . . . cord-335975-m6lkrehi 4394 1 Noflow noflow JJ cord-335975-m6lkrehi 4394 2 time time NN cord-335975-m6lkrehi 4394 3 and and CC cord-335975-m6lkrehi 4394 4 low low JJ cord-335975-m6lkrehi 4394 5 - - HYPH cord-335975-m6lkrehi 4394 6 flow flow NN cord-335975-m6lkrehi 4394 7 time time NN cord-335975-m6lkrehi 4394 8 were be VBD cord-335975-m6lkrehi 4394 9 respectively respectively RB cord-335975-m6lkrehi 4394 10 3.7 3.7 CD cord-335975-m6lkrehi 4394 11 and and CC cord-335975-m6lkrehi 4394 12 17 17 CD cord-335975-m6lkrehi 4394 13 min min NN cord-335975-m6lkrehi 4394 14 . . . cord-335975-m6lkrehi 4395 1 Hypothermia hypothermia NN cord-335975-m6lkrehi 4395 2 was be VBD cord-335975-m6lkrehi 4395 3 performed perform VBN cord-335975-m6lkrehi 4395 4 in in IN cord-335975-m6lkrehi 4395 5 30 30 CD cord-335975-m6lkrehi 4395 6 ( ( -LRB- cord-335975-m6lkrehi 4395 7 63 63 CD cord-335975-m6lkrehi 4395 8 % % NN cord-335975-m6lkrehi 4395 9 ) ) -RRB- cord-335975-m6lkrehi 4395 10 patients patient NNS cord-335975-m6lkrehi 4395 11 . . . cord-335975-m6lkrehi 4396 1 27 27 CD cord-335975-m6lkrehi 4396 2 patients patient NNS cord-335975-m6lkrehi 4396 3 ( ( -LRB- cord-335975-m6lkrehi 4396 4 56 56 CD cord-335975-m6lkrehi 4396 5 % % NN cord-335975-m6lkrehi 4396 6 ) ) -RRB- cord-335975-m6lkrehi 4396 7 died die VBD cord-335975-m6lkrehi 4396 8 in in IN cord-335975-m6lkrehi 4396 9 the the DT cord-335975-m6lkrehi 4396 10 ICU ICU NNP cord-335975-m6lkrehi 4396 11 . . . cord-335975-m6lkrehi 4397 1 The the DT cord-335975-m6lkrehi 4397 2 30-day 30-day CD cord-335975-m6lkrehi 4397 3 and and CC cord-335975-m6lkrehi 4397 4 6-months 6-months CD cord-335975-m6lkrehi 4397 5 survival survival NN cord-335975-m6lkrehi 4397 6 rates rate NNS cord-335975-m6lkrehi 4397 7 were be VBD cord-335975-m6lkrehi 4397 8 respectively respectively RB cord-335975-m6lkrehi 4397 9 44 44 CD cord-335975-m6lkrehi 4397 10 and and CC cord-335975-m6lkrehi 4397 11 42 42 CD cord-335975-m6lkrehi 4397 12 % % NN cord-335975-m6lkrehi 4397 13 with with IN cord-335975-m6lkrehi 4397 14 a a DT cord-335975-m6lkrehi 4397 15 favorable favorable JJ cord-335975-m6lkrehi 4397 16 outcome outcome NN cord-335975-m6lkrehi 4397 17 of of IN cord-335975-m6lkrehi 4397 18 35 35 CD cord-335975-m6lkrehi 4397 19 % % NN cord-335975-m6lkrehi 4397 20 at at IN cord-335975-m6lkrehi 4397 21 6 6 CD cord-335975-m6lkrehi 4397 22 months month NNS cord-335975-m6lkrehi 4397 23 . . . cord-335975-m6lkrehi 4398 1 On on IN cord-335975-m6lkrehi 4398 2 the the DT cord-335975-m6lkrehi 4398 3 ROC ROC NNP cord-335975-m6lkrehi 4398 4 curve curve NN cord-335975-m6lkrehi 4398 5 we -PRON- PRP cord-335975-m6lkrehi 4398 6 found find VBD cord-335975-m6lkrehi 4398 7 a a DT cord-335975-m6lkrehi 4398 8 cut cut VBN cord-335975-m6lkrehi 4398 9 - - HYPH cord-335975-m6lkrehi 4398 10 off off RP cord-335975-m6lkrehi 4398 11 value value NN cord-335975-m6lkrehi 4398 12 of of IN cord-335975-m6lkrehi 4398 13 41 41 CD cord-335975-m6lkrehi 4398 14 ng ng NN cord-335975-m6lkrehi 4398 15 ml ml NN cord-335975-m6lkrehi 4398 16 with with IN cord-335975-m6lkrehi 4398 17 specificity specificity NN cord-335975-m6lkrehi 4398 18 of of IN cord-335975-m6lkrehi 4398 19 0.95 0.95 CD cord-335975-m6lkrehi 4398 20 CI CI NNP cord-335975-m6lkrehi 4398 21 95 95 CD cord-335975-m6lkrehi 4398 22 % % NN cord-335975-m6lkrehi 4398 23 ( ( -LRB- cord-335975-m6lkrehi 4398 24 0.75 0.75 CD cord-335975-m6lkrehi 4398 25 - - SYM cord-335975-m6lkrehi 4398 26 0.99 0.99 CD cord-335975-m6lkrehi 4398 27 ) ) -RRB- cord-335975-m6lkrehi 4398 28 and and CC cord-335975-m6lkrehi 4398 29 a a DT cord-335975-m6lkrehi 4398 30 sensibility sensibility NN cord-335975-m6lkrehi 4398 31 of of IN cord-335975-m6lkrehi 4398 32 0.64 0.64 CD cord-335975-m6lkrehi 4398 33 CI CI NNP cord-335975-m6lkrehi 4398 34 95%(0.44 95%(0.44 CD cord-335975-m6lkrehi 4398 35 - - HYPH cord-335975-m6lkrehi 4398 36 0.81 0.81 CD cord-335975-m6lkrehi 4398 37 ) ) -RRB- cord-335975-m6lkrehi 4398 38 . . . cord-335975-m6lkrehi 4399 1 Area area NN cord-335975-m6lkrehi 4399 2 under under IN cord-335975-m6lkrehi 4399 3 curve curve NN cord-335975-m6lkrehi 4399 4 was be VBD cord-335975-m6lkrehi 4399 5 0.828 0.828 CD cord-335975-m6lkrehi 4399 6 CI CI NNP cord-335975-m6lkrehi 4399 7 95 95 CD cord-335975-m6lkrehi 4399 8 % % NN cord-335975-m6lkrehi 4399 9 ( ( -LRB- cord-335975-m6lkrehi 4399 10 0.713 0.713 CD cord-335975-m6lkrehi 4399 11 - - SYM cord-335975-m6lkrehi 4399 12 0.942 0.942 CD cord-335975-m6lkrehi 4399 13 ) ) -RRB- cord-335975-m6lkrehi 4399 14 . . . cord-335975-m6lkrehi 4400 1 9 9 CD cord-335975-m6lkrehi 4400 2 out out IN cord-335975-m6lkrehi 4400 3 of of IN cord-335975-m6lkrehi 4400 4 the the DT cord-335975-m6lkrehi 4400 5 10 10 CD cord-335975-m6lkrehi 4400 6 patients patient NNS cord-335975-m6lkrehi 4400 7 with with IN cord-335975-m6lkrehi 4400 8 a a DT cord-335975-m6lkrehi 4400 9 rising rise VBG cord-335975-m6lkrehi 4400 10 NSE nse NN cord-335975-m6lkrehi 4400 11 between between IN cord-335975-m6lkrehi 4400 12 H24 H24 NNP cord-335975-m6lkrehi 4400 13 and and CC cord-335975-m6lkrehi 4400 14 H72 H72 NNP cord-335975-m6lkrehi 4400 15 had have VBD cord-335975-m6lkrehi 4400 16 an an DT cord-335975-m6lkrehi 4400 17 unfavorable unfavorable JJ cord-335975-m6lkrehi 4400 18 outcome outcome NN cord-335975-m6lkrehi 4400 19 . . . cord-335975-m6lkrehi 4401 1 Among among IN cord-335975-m6lkrehi 4401 2 patients patient NNS cord-335975-m6lkrehi 4401 3 with with IN cord-335975-m6lkrehi 4401 4 NSE NSE NNP cord-335975-m6lkrehi 4401 5 > > SYM cord-335975-m6lkrehi 4401 6 41 41 CD cord-335975-m6lkrehi 4401 7 ng ng NNP cord-335975-m6lkrehi 4401 8 ml ml NN cord-335975-m6lkrehi 4401 9 , , , cord-335975-m6lkrehi 4401 10 the the DT cord-335975-m6lkrehi 4401 11 cortical cortical JJ cord-335975-m6lkrehi 4401 12 N20 N20 NNP cord-335975-m6lkrehi 4401 13 responses response NNS cord-335975-m6lkrehi 4401 14 were be VBD cord-335975-m6lkrehi 4401 15 bilaterally bilaterally RB cord-335975-m6lkrehi 4401 16 present present JJ cord-335975-m6lkrehi 4401 17 in in IN cord-335975-m6lkrehi 4401 18 4 4 CD cord-335975-m6lkrehi 4401 19 of of IN cord-335975-m6lkrehi 4401 20 them -PRON- PRP cord-335975-m6lkrehi 4401 21 . . . cord-335975-m6lkrehi 4402 1 Conclusion conclusion NN cord-335975-m6lkrehi 4402 2 : : : cord-335975-m6lkrehi 4403 1 In in IN cord-335975-m6lkrehi 4403 2 our -PRON- PRP$ cord-335975-m6lkrehi 4403 3 study study NN cord-335975-m6lkrehi 4403 4 NSE NSE NNP cord-335975-m6lkrehi 4403 5 value value NN cord-335975-m6lkrehi 4403 6 over over IN cord-335975-m6lkrehi 4403 7 than than IN cord-335975-m6lkrehi 4403 8 41 41 CD cord-335975-m6lkrehi 4403 9 ng ng NN cord-335975-m6lkrehi 4403 10 ml ml NN cord-335975-m6lkrehi 4403 11 at at IN cord-335975-m6lkrehi 4403 12 H24 H24 NNP cord-335975-m6lkrehi 4403 13 was be VBD cord-335975-m6lkrehi 4403 14 predictive predictive JJ cord-335975-m6lkrehi 4403 15 of of IN cord-335975-m6lkrehi 4403 16 poor poor JJ cord-335975-m6lkrehi 4403 17 neurological neurological JJ cord-335975-m6lkrehi 4403 18 outcome outcome NN cord-335975-m6lkrehi 4403 19 after after IN cord-335975-m6lkrehi 4403 20 cardiac cardiac JJ cord-335975-m6lkrehi 4403 21 arrest arrest NN cord-335975-m6lkrehi 4403 22 . . . cord-335975-m6lkrehi 4404 1 NSE NSE NNP cord-335975-m6lkrehi 4404 2 may may MD cord-335975-m6lkrehi 4404 3 prove prove VB cord-335975-m6lkrehi 4404 4 to to TO cord-335975-m6lkrehi 4404 5 be be VB cord-335975-m6lkrehi 4404 6 a a DT cord-335975-m6lkrehi 4404 7 useful useful JJ cord-335975-m6lkrehi 4404 8 marker marker NN cord-335975-m6lkrehi 4404 9 in in IN cord-335975-m6lkrehi 4404 10 patients patient NNS cord-335975-m6lkrehi 4404 11 with with IN cord-335975-m6lkrehi 4404 12 present present JJ cord-335975-m6lkrehi 4404 13 N20 N20 NNP cord-335975-m6lkrehi 4404 14 responses response NNS cord-335975-m6lkrehi 4404 15 , , , cord-335975-m6lkrehi 4404 16 possibly possibly RB cord-335975-m6lkrehi 4404 17 limiting limit VBG cord-335975-m6lkrehi 4404 18 the the DT cord-335975-m6lkrehi 4404 19 duration duration NN cord-335975-m6lkrehi 4404 20 of of IN cord-335975-m6lkrehi 4404 21 hospitalization hospitalization NN cord-335975-m6lkrehi 4404 22 by by IN cord-335975-m6lkrehi 4404 23 introducing introduce VBG cord-335975-m6lkrehi 4404 24 therapeutic therapeutic JJ cord-335975-m6lkrehi 4404 25 limitation limitation NN cord-335975-m6lkrehi 4404 26 or or CC cord-335975-m6lkrehi 4404 27 withdrawal withdrawal NN cord-335975-m6lkrehi 4404 28 of of IN cord-335975-m6lkrehi 4404 29 support support NN cord-335975-m6lkrehi 4404 30 . . . cord-335975-m6lkrehi 4405 1 Physicians physician NNS cord-335975-m6lkrehi 4405 2 assessment assessment NN cord-335975-m6lkrehi 4405 3 of of IN cord-335975-m6lkrehi 4405 4 prognosis prognosis NN cord-335975-m6lkrehi 4405 5 in in IN cord-335975-m6lkrehi 4405 6 ICU ICU NNP cord-335975-m6lkrehi 4405 7 patients patient NNS cord-335975-m6lkrehi 4405 8 with with IN cord-335975-m6lkrehi 4405 9 brain brain NN cord-335975-m6lkrehi 4405 10 Introduction introduction NN cord-335975-m6lkrehi 4405 11 : : : cord-335975-m6lkrehi 4406 1 Outcome outcome NN cord-335975-m6lkrehi 4406 2 prediction prediction NN cord-335975-m6lkrehi 4406 3 in in IN cord-335975-m6lkrehi 4406 4 ICU ICU NNP cord-335975-m6lkrehi 4406 5 patients patient NNS cord-335975-m6lkrehi 4406 6 with with IN cord-335975-m6lkrehi 4406 7 severe severe JJ cord-335975-m6lkrehi 4406 8 brain brain NN cord-335975-m6lkrehi 4406 9 damage damage NN cord-335975-m6lkrehi 4406 10 is be VBZ cord-335975-m6lkrehi 4406 11 a a DT cord-335975-m6lkrehi 4406 12 difficult difficult JJ cord-335975-m6lkrehi 4406 13 task task NN cord-335975-m6lkrehi 4406 14 with with IN cord-335975-m6lkrehi 4406 15 observed observed JJ cord-335975-m6lkrehi 4406 16 heterogeneity heterogeneity NN cord-335975-m6lkrehi 4406 17 in in IN cord-335975-m6lkrehi 4406 18 physicians physician NNS cord-335975-m6lkrehi 4406 19 estimation estimation NN cord-335975-m6lkrehi 4406 20 . . . cord-335975-m6lkrehi 4407 1 The the DT cord-335975-m6lkrehi 4407 2 aim aim NN cord-335975-m6lkrehi 4407 3 of of IN cord-335975-m6lkrehi 4407 4 the the DT cord-335975-m6lkrehi 4407 5 survey survey NN cord-335975-m6lkrehi 4407 6 was be VBD cord-335975-m6lkrehi 4407 7 to to TO cord-335975-m6lkrehi 4407 8 evaluate evaluate VB cord-335975-m6lkrehi 4407 9 the the DT cord-335975-m6lkrehi 4407 10 prognostic prognostic JJ cord-335975-m6lkrehi 4407 11 estimates estimate NNS cord-335975-m6lkrehi 4407 12 and and CC cord-335975-m6lkrehi 4407 13 treatment treatment NN cord-335975-m6lkrehi 4407 14 recommendation recommendation NN cord-335975-m6lkrehi 4407 15 of of IN cord-335975-m6lkrehi 4407 16 intensivists intensivists NNP cord-335975-m6lkrehi 4407 17 in in IN cord-335975-m6lkrehi 4407 18 real real JJ cord-335975-m6lkrehi 4407 19 patients patient NNS cord-335975-m6lkrehi 4407 20 with with IN cord-335975-m6lkrehi 4407 21 various various JJ cord-335975-m6lkrehi 4407 22 causes cause NNS cord-335975-m6lkrehi 4407 23 of of IN cord-335975-m6lkrehi 4407 24 severe severe JJ cord-335975-m6lkrehi 4407 25 brain brain NN cord-335975-m6lkrehi 4407 26 damage damage NN cord-335975-m6lkrehi 4407 27 . . . cord-335975-m6lkrehi 4408 1 Patients patient NNS cord-335975-m6lkrehi 4408 2 and and CC cord-335975-m6lkrehi 4408 3 methods method NNS cord-335975-m6lkrehi 4408 4 : : : cord-335975-m6lkrehi 4408 5 A a DT cord-335975-m6lkrehi 4408 6 web web NN cord-335975-m6lkrehi 4408 7 anonymous anonymous JJ cord-335975-m6lkrehi 4408 8 survey survey NN cord-335975-m6lkrehi 4408 9 including include VBG cord-335975-m6lkrehi 4408 10 a a DT cord-335975-m6lkrehi 4408 11 summarized summarize VBN cord-335975-m6lkrehi 4408 12 clinical clinical JJ cord-335975-m6lkrehi 4408 13 report report NN cord-335975-m6lkrehi 4408 14 of of IN cord-335975-m6lkrehi 4408 15 four four CD cord-335975-m6lkrehi 4408 16 patients patient NNS cord-335975-m6lkrehi 4408 17 who who WP cord-335975-m6lkrehi 4408 18 stayed stay VBD cord-335975-m6lkrehi 4408 19 in in IN cord-335975-m6lkrehi 4408 20 the the DT cord-335975-m6lkrehi 4408 21 ICU ICU NNP cord-335975-m6lkrehi 4408 22 was be VBD cord-335975-m6lkrehi 4408 23 submitted submit VBN cord-335975-m6lkrehi 4408 24 to to IN cord-335975-m6lkrehi 4408 25 French french JJ cord-335975-m6lkrehi 4408 26 intensivists intensivist NNS cord-335975-m6lkrehi 4408 27 . . . cord-335975-m6lkrehi 4409 1 Patient patient NN cord-335975-m6lkrehi 4409 2 1 1 CD cord-335975-m6lkrehi 4409 3 presented present VBD cord-335975-m6lkrehi 4409 4 with with IN cord-335975-m6lkrehi 4409 5 prolonged prolonged JJ cord-335975-m6lkrehi 4409 6 hypoglycemic hypoglycemic JJ cord-335975-m6lkrehi 4409 7 coma coma NN cord-335975-m6lkrehi 4409 8 , , , cord-335975-m6lkrehi 4409 9 patient patient JJ cord-335975-m6lkrehi 4409 10 2 2 CD cord-335975-m6lkrehi 4409 11 with with IN cord-335975-m6lkrehi 4409 12 intracerebral intracerebral JJ cord-335975-m6lkrehi 4409 13 hemorrhage hemorrhage NN cord-335975-m6lkrehi 4409 14 , , , cord-335975-m6lkrehi 4409 15 patient patient JJ cord-335975-m6lkrehi 4409 16 3 3 CD cord-335975-m6lkrehi 4409 17 with with IN cord-335975-m6lkrehi 4409 18 central central JJ cord-335975-m6lkrehi 4409 19 and and CC cord-335975-m6lkrehi 4409 20 extra extra JJ cord-335975-m6lkrehi 4409 21 pontine pontine JJ cord-335975-m6lkrehi 4409 22 myelinolysis myelinolysis NN cord-335975-m6lkrehi 4409 23 , , , cord-335975-m6lkrehi 4409 24 patient patient JJ cord-335975-m6lkrehi 4409 25 4 4 CD cord-335975-m6lkrehi 4409 26 with with IN cord-335975-m6lkrehi 4409 27 a a DT cord-335975-m6lkrehi 4409 28 brainstem brainstem NN cord-335975-m6lkrehi 4409 29 hemorrhage hemorrhage NN cord-335975-m6lkrehi 4409 30 . . . cord-335975-m6lkrehi 4410 1 All all PDT cord-335975-m6lkrehi 4410 2 these these DT cord-335975-m6lkrehi 4410 3 patients patient NNS cord-335975-m6lkrehi 4410 4 received receive VBD cord-335975-m6lkrehi 4410 5 full full JJ cord-335975-m6lkrehi 4410 6 treatment treatment NN cord-335975-m6lkrehi 4410 7 in in IN cord-335975-m6lkrehi 4410 8 the the DT cord-335975-m6lkrehi 4410 9 ICU ICU NNP cord-335975-m6lkrehi 4410 10 and and CC cord-335975-m6lkrehi 4410 11 had have VBD cord-335975-m6lkrehi 4410 12 a a DT cord-335975-m6lkrehi 4410 13 6-month 6-month CD cord-335975-m6lkrehi 4410 14 follow follow NN cord-335975-m6lkrehi 4410 15 - - HYPH cord-335975-m6lkrehi 4410 16 up up NN cord-335975-m6lkrehi 4410 17 . . . cord-335975-m6lkrehi 4411 1 Physicians physician NNS cord-335975-m6lkrehi 4411 2 were be VBD cord-335975-m6lkrehi 4411 3 provided provide VBN cord-335975-m6lkrehi 4411 4 with with IN cord-335975-m6lkrehi 4411 5 the the DT cord-335975-m6lkrehi 4411 6 four four CD cord-335975-m6lkrehi 4411 7 clinical clinical JJ cord-335975-m6lkrehi 4411 8 vignettes vignette NNS cord-335975-m6lkrehi 4411 9 including include VBG cord-335975-m6lkrehi 4411 10 clinical clinical JJ cord-335975-m6lkrehi 4411 11 history history NN cord-335975-m6lkrehi 4411 12 , , , cord-335975-m6lkrehi 4411 13 brain brain NN cord-335975-m6lkrehi 4411 14 imaging imaging NN cord-335975-m6lkrehi 4411 15 and and CC cord-335975-m6lkrehi 4411 16 other other JJ cord-335975-m6lkrehi 4411 17 relevant relevant JJ cord-335975-m6lkrehi 4411 18 exams exam NNS cord-335975-m6lkrehi 4411 19 ( ( -LRB- cord-335975-m6lkrehi 4411 20 CSF CSF NNP cord-335975-m6lkrehi 4411 21 , , , cord-335975-m6lkrehi 4411 22 EEG EEG NNP cord-335975-m6lkrehi 4411 23 , , , cord-335975-m6lkrehi 4411 24 … … NFP cord-335975-m6lkrehi 4411 25 ) ) -RRB- cord-335975-m6lkrehi 4411 26 , , , cord-335975-m6lkrehi 4411 27 evolution evolution NN cord-335975-m6lkrehi 4411 28 of of IN cord-335975-m6lkrehi 4411 29 symptoms symptom NNS cord-335975-m6lkrehi 4411 30 within within IN cord-335975-m6lkrehi 4411 31 the the DT cord-335975-m6lkrehi 4411 32 first first JJ cord-335975-m6lkrehi 4411 33 days day NNS cord-335975-m6lkrehi 4411 34 of of IN cord-335975-m6lkrehi 4411 35 the the DT cord-335975-m6lkrehi 4411 36 ICU ICU NNP cord-335975-m6lkrehi 4411 37 stay stay NN cord-335975-m6lkrehi 4411 38 . . . cord-335975-m6lkrehi 4412 1 They -PRON- PRP cord-335975-m6lkrehi 4412 2 had have VBD cord-335975-m6lkrehi 4412 3 to to TO cord-335975-m6lkrehi 4412 4 estimate estimate VB cord-335975-m6lkrehi 4412 5 6-month 6-month CD cord-335975-m6lkrehi 4412 6 outcome outcome NN cord-335975-m6lkrehi 4412 7 using use VBG cord-335975-m6lkrehi 4412 8 modified modify VBN cord-335975-m6lkrehi 4412 9 Rankin Rankin NNP cord-335975-m6lkrehi 4412 10 scale scale NN cord-335975-m6lkrehi 4412 11 ( ( -LRB- cord-335975-m6lkrehi 4412 12 mRS mrs UH cord-335975-m6lkrehi 4412 13 ) ) -RRB- cord-335975-m6lkrehi 4412 14 where where WRB cord-335975-m6lkrehi 4412 15 a a DT cord-335975-m6lkrehi 4412 16 score score NN cord-335975-m6lkrehi 4412 17 from from IN cord-335975-m6lkrehi 4412 18 0 0 CD cord-335975-m6lkrehi 4412 19 to to IN cord-335975-m6lkrehi 4412 20 3 3 CD cord-335975-m6lkrehi 4412 21 was be VBD cord-335975-m6lkrehi 4412 22 considered consider VBN cord-335975-m6lkrehi 4412 23 as as IN cord-335975-m6lkrehi 4412 24 a a DT cord-335975-m6lkrehi 4412 25 good good JJ cord-335975-m6lkrehi 4412 26 outcome outcome NN cord-335975-m6lkrehi 4412 27 and and CC cord-335975-m6lkrehi 4412 28 4 4 CD cord-335975-m6lkrehi 4412 29 to to IN cord-335975-m6lkrehi 4412 30 6 6 CD cord-335975-m6lkrehi 4412 31 as as IN cord-335975-m6lkrehi 4412 32 a a DT cord-335975-m6lkrehi 4412 33 poor poor JJ cord-335975-m6lkrehi 4412 34 outcome outcome NN cord-335975-m6lkrehi 4412 35 . . . cord-335975-m6lkrehi 4413 1 They -PRON- PRP cord-335975-m6lkrehi 4413 2 had have VBD cord-335975-m6lkrehi 4413 3 to to TO cord-335975-m6lkrehi 4413 4 provide provide VB cord-335975-m6lkrehi 4413 5 a a DT cord-335975-m6lkrehi 4413 6 recommendation recommendation NN cord-335975-m6lkrehi 4413 7 about about IN cord-335975-m6lkrehi 4413 8 care care NN cord-335975-m6lkrehi 4413 9 among among IN cord-335975-m6lkrehi 4413 10 the the DT cord-335975-m6lkrehi 4413 11 following follow VBG cord-335975-m6lkrehi 4413 12 - - HYPH cord-335975-m6lkrehi 4413 13 full full JJ cord-335975-m6lkrehi 4413 14 treatment treatment NN cord-335975-m6lkrehi 4413 15 , , , cord-335975-m6lkrehi 4413 16 care care NN cord-335975-m6lkrehi 4413 17 limitation limitation NN cord-335975-m6lkrehi 4413 18 , , , cord-335975-m6lkrehi 4413 19 care care NN cord-335975-m6lkrehi 4413 20 withdrawal withdrawal NN cord-335975-m6lkrehi 4413 21 . . . cord-335975-m6lkrehi 4414 1 Results result NNS cord-335975-m6lkrehi 4414 2 : : : cord-335975-m6lkrehi 4414 3 109 109 CD cord-335975-m6lkrehi 4414 4 physicians physician NNS cord-335975-m6lkrehi 4414 5 completed complete VBD cord-335975-m6lkrehi 4414 6 the the DT cord-335975-m6lkrehi 4414 7 survey survey NN cord-335975-m6lkrehi 4414 8 . . . cord-335975-m6lkrehi 4415 1 There there EX cord-335975-m6lkrehi 4415 2 were be VBD cord-335975-m6lkrehi 4415 3 37 37 CD cord-335975-m6lkrehi 4415 4 ( ( -LRB- cord-335975-m6lkrehi 4415 5 33.9 33.9 CD cord-335975-m6lkrehi 4415 6 % % NN cord-335975-m6lkrehi 4415 7 ) ) -RRB- cord-335975-m6lkrehi 4415 8 female female NN cord-335975-m6lkrehi 4415 9 . . . cord-335975-m6lkrehi 4416 1 48 48 CD cord-335975-m6lkrehi 4416 2 ( ( -LRB- cord-335975-m6lkrehi 4416 3 44 44 CD cord-335975-m6lkrehi 4416 4 % % NN cord-335975-m6lkrehi 4416 5 ) ) -RRB- cord-335975-m6lkrehi 4416 6 respondents respondent NNS cord-335975-m6lkrehi 4416 7 were be VBD cord-335975-m6lkrehi 4416 8 residents resident NNS cord-335975-m6lkrehi 4416 9 and and CC cord-335975-m6lkrehi 4416 10 20 20 CD cord-335975-m6lkrehi 4416 11 ( ( -LRB- cord-335975-m6lkrehi 4416 12 18.3 18.3 CD cord-335975-m6lkrehi 4416 13 % % NN cord-335975-m6lkrehi 4416 14 ) ) -RRB- cord-335975-m6lkrehi 4416 15 had have VBD cord-335975-m6lkrehi 4416 16 a a DT cord-335975-m6lkrehi 4416 17 > > NN cord-335975-m6lkrehi 4416 18 10-year 10-year CD cord-335975-m6lkrehi 4416 19 of of IN cord-335975-m6lkrehi 4416 20 experience experience NN cord-335975-m6lkrehi 4416 21 . . . cord-335975-m6lkrehi 4417 1 Patients patient NNS cord-335975-m6lkrehi 4417 2 1 1 CD cord-335975-m6lkrehi 4417 3 and and CC cord-335975-m6lkrehi 4417 4 2 2 CD cord-335975-m6lkrehi 4417 5 had have VBD cord-335975-m6lkrehi 4417 6 a a DT cord-335975-m6lkrehi 4417 7 good good JJ cord-335975-m6lkrehi 4417 8 6-month 6-month CD cord-335975-m6lkrehi 4417 9 outcome outcome NN cord-335975-m6lkrehi 4417 10 with with IN cord-335975-m6lkrehi 4417 11 mRS mrs XX cord-335975-m6lkrehi 4417 12 1 1 CD cord-335975-m6lkrehi 4417 13 and and CC cord-335975-m6lkrehi 4417 14 mRS mrs PRP$ cord-335975-m6lkrehi 4417 15 2 2 CD cord-335975-m6lkrehi 4417 16 respectively respectively RB cord-335975-m6lkrehi 4417 17 while while IN cord-335975-m6lkrehi 4417 18 patients patient NNS cord-335975-m6lkrehi 4417 19 3 3 CD cord-335975-m6lkrehi 4417 20 and and CC cord-335975-m6lkrehi 4417 21 4 4 CD cord-335975-m6lkrehi 4417 22 had have VBD cord-335975-m6lkrehi 4417 23 a a DT cord-335975-m6lkrehi 4417 24 poor poor JJ cord-335975-m6lkrehi 4417 25 outcome outcome NN cord-335975-m6lkrehi 4417 26 , , , cord-335975-m6lkrehi 4417 27 both both CC cord-335975-m6lkrehi 4417 28 with with IN cord-335975-m6lkrehi 4417 29 mRS mRS NNP cord-335975-m6lkrehi 4417 30 5 5 CD cord-335975-m6lkrehi 4417 31 . . . cord-335975-m6lkrehi 4418 1 Correct correct JJ cord-335975-m6lkrehi 4418 2 prognosis prognosis NN cord-335975-m6lkrehi 4418 3 estimations estimation NNS cord-335975-m6lkrehi 4418 4 were be VBD cord-335975-m6lkrehi 4418 5 36 36 CD cord-335975-m6lkrehi 4418 6 ( ( -LRB- cord-335975-m6lkrehi 4418 7 33 33 CD cord-335975-m6lkrehi 4418 8 % % NN cord-335975-m6lkrehi 4418 9 ) ) -RRB- cord-335975-m6lkrehi 4418 10 , , , cord-335975-m6lkrehi 4418 11 31 31 CD cord-335975-m6lkrehi 4418 12 ( ( -LRB- cord-335975-m6lkrehi 4418 13 28.4 28.4 CD cord-335975-m6lkrehi 4418 14 % % NN cord-335975-m6lkrehi 4418 15 ) ) -RRB- cord-335975-m6lkrehi 4418 16 , , , cord-335975-m6lkrehi 4418 17 97 97 CD cord-335975-m6lkrehi 4418 18 ( ( -LRB- cord-335975-m6lkrehi 4418 19 89 89 CD cord-335975-m6lkrehi 4418 20 % % NN cord-335975-m6lkrehi 4418 21 ) ) -RRB- cord-335975-m6lkrehi 4418 22 and and CC cord-335975-m6lkrehi 4418 23 100 100 CD cord-335975-m6lkrehi 4418 24 ( ( -LRB- cord-335975-m6lkrehi 4418 25 91.7 91.7 CD cord-335975-m6lkrehi 4418 26 % % NN cord-335975-m6lkrehi 4418 27 ) ) -RRB- cord-335975-m6lkrehi 4418 28 in in IN cord-335975-m6lkrehi 4418 29 patients patient NNS cord-335975-m6lkrehi 4418 30 1 1 CD cord-335975-m6lkrehi 4418 31 to to IN cord-335975-m6lkrehi 4418 32 4 4 CD cord-335975-m6lkrehi 4418 33 respectively respectively RB cord-335975-m6lkrehi 4418 34 . . . cord-335975-m6lkrehi 4419 1 Care care NN cord-335975-m6lkrehi 4419 2 limitation limitation NN cord-335975-m6lkrehi 4419 3 or or CC cord-335975-m6lkrehi 4419 4 withdrawal withdrawal NN cord-335975-m6lkrehi 4419 5 was be VBD cord-335975-m6lkrehi 4419 6 recommended recommend VBN cord-335975-m6lkrehi 4419 7 by by IN cord-335975-m6lkrehi 4419 8 70 70 CD cord-335975-m6lkrehi 4419 9 ( ( -LRB- cord-335975-m6lkrehi 4419 10 64.2 64.2 CD cord-335975-m6lkrehi 4419 11 % % NN cord-335975-m6lkrehi 4419 12 ) ) -RRB- cord-335975-m6lkrehi 4419 13 , , , cord-335975-m6lkrehi 4419 14 40 40 CD cord-335975-m6lkrehi 4419 15 ( ( -LRB- cord-335975-m6lkrehi 4419 16 36.7 36.7 CD cord-335975-m6lkrehi 4419 17 % % NN cord-335975-m6lkrehi 4419 18 ) ) -RRB- cord-335975-m6lkrehi 4419 19 , , , cord-335975-m6lkrehi 4419 20 73 73 CD cord-335975-m6lkrehi 4419 21 ( ( -LRB- cord-335975-m6lkrehi 4419 22 67 67 CD cord-335975-m6lkrehi 4419 23 % % NN cord-335975-m6lkrehi 4419 24 ) ) -RRB- cord-335975-m6lkrehi 4419 25 and and CC cord-335975-m6lkrehi 4419 26 73 73 CD cord-335975-m6lkrehi 4419 27 ( ( -LRB- cord-335975-m6lkrehi 4419 28 67 67 CD cord-335975-m6lkrehi 4419 29 % % NN cord-335975-m6lkrehi 4419 30 ) ) -RRB- cord-335975-m6lkrehi 4419 31 respondents respondent NNS cord-335975-m6lkrehi 4419 32 in in IN cord-335975-m6lkrehi 4419 33 patients patient NNS cord-335975-m6lkrehi 4419 34 1 1 CD cord-335975-m6lkrehi 4419 35 to to IN cord-335975-m6lkrehi 4419 36 4 4 CD cord-335975-m6lkrehi 4419 37 respectively respectively RB cord-335975-m6lkrehi 4419 38 . . . cord-335975-m6lkrehi 4420 1 Of of IN cord-335975-m6lkrehi 4420 2 interest interest NN cord-335975-m6lkrehi 4420 3 , , , cord-335975-m6lkrehi 4420 4 care care NN cord-335975-m6lkrehi 4420 5 withdrawal withdrawal NN cord-335975-m6lkrehi 4420 6 was be VBD cord-335975-m6lkrehi 4420 7 recommended recommend VBN cord-335975-m6lkrehi 4420 8 by by IN cord-335975-m6lkrehi 4420 9 2 2 CD cord-335975-m6lkrehi 4420 10 ( ( -LRB- cord-335975-m6lkrehi 4420 11 1.8 1.8 CD cord-335975-m6lkrehi 4420 12 % % NN cord-335975-m6lkrehi 4420 13 ) ) -RRB- cord-335975-m6lkrehi 4420 14 , , , cord-335975-m6lkrehi 4420 15 4 4 CD cord-335975-m6lkrehi 4420 16 ( ( -LRB- cord-335975-m6lkrehi 4420 17 3.7 3.7 CD cord-335975-m6lkrehi 4420 18 % % NN cord-335975-m6lkrehi 4420 19 ) ) -RRB- cord-335975-m6lkrehi 4420 20 , , , cord-335975-m6lkrehi 4420 21 19 19 CD cord-335975-m6lkrehi 4420 22 ( ( -LRB- cord-335975-m6lkrehi 4420 23 17.4 17.4 CD cord-335975-m6lkrehi 4420 24 % % NN cord-335975-m6lkrehi 4420 25 ) ) -RRB- cord-335975-m6lkrehi 4420 26 and and CC cord-335975-m6lkrehi 4420 27 25 25 CD cord-335975-m6lkrehi 4420 28 ( ( -LRB- cord-335975-m6lkrehi 4420 29 22.9 22.9 CD cord-335975-m6lkrehi 4420 30 % % NN cord-335975-m6lkrehi 4420 31 ) ) -RRB- cord-335975-m6lkrehi 4420 32 respondents respondent NNS cord-335975-m6lkrehi 4420 33 in in IN cord-335975-m6lkrehi 4420 34 patients patient NNS cord-335975-m6lkrehi 4420 35 1 1 CD cord-335975-m6lkrehi 4420 36 to to IN cord-335975-m6lkrehi 4420 37 4 4 CD cord-335975-m6lkrehi 4420 38 respectively respectively RB cord-335975-m6lkrehi 4420 39 . . . cord-335975-m6lkrehi 4421 1 Univariate Univariate NNP cord-335975-m6lkrehi 4421 2 analysis analysis NN cord-335975-m6lkrehi 4421 3 did do VBD cord-335975-m6lkrehi 4421 4 not not RB cord-335975-m6lkrehi 4421 5 display display VB cord-335975-m6lkrehi 4421 6 any any DT cord-335975-m6lkrehi 4421 7 factor factor NN cord-335975-m6lkrehi 4421 8 related relate VBN cord-335975-m6lkrehi 4421 9 with with IN cord-335975-m6lkrehi 4421 10 a a DT cord-335975-m6lkrehi 4421 11 good good JJ cord-335975-m6lkrehi 4421 12 prediction prediction NN cord-335975-m6lkrehi 4421 13 of of IN cord-335975-m6lkrehi 4421 14 prognosis prognosis NN cord-335975-m6lkrehi 4421 15 . . . cord-335975-m6lkrehi 4422 1 Conclusion conclusion NN cord-335975-m6lkrehi 4422 2 : : : cord-335975-m6lkrehi 4423 1 In in IN cord-335975-m6lkrehi 4423 2 this this DT cord-335975-m6lkrehi 4423 3 study study NN cord-335975-m6lkrehi 4423 4 , , , cord-335975-m6lkrehi 4423 5 overall overall JJ cord-335975-m6lkrehi 4423 6 predictions prediction NNS cord-335975-m6lkrehi 4423 7 were be VBD cord-335975-m6lkrehi 4423 8 pessimistic pessimistic JJ cord-335975-m6lkrehi 4423 9 with with IN cord-335975-m6lkrehi 4423 10 important important JJ cord-335975-m6lkrehi 4423 11 variations variation NNS cord-335975-m6lkrehi 4423 12 among among IN cord-335975-m6lkrehi 4423 13 respondents respondent NNS cord-335975-m6lkrehi 4423 14 . . . cord-335975-m6lkrehi 4424 1 Although although IN cord-335975-m6lkrehi 4424 2 decisions decision NNS cord-335975-m6lkrehi 4424 3 to to TO cord-335975-m6lkrehi 4424 4 withdraw withdraw VB cord-335975-m6lkrehi 4424 5 life life NN cord-335975-m6lkrehi 4424 6 sustaining sustain VBG cord-335975-m6lkrehi 4424 7 care care NN cord-335975-m6lkrehi 4424 8 were be VBD cord-335975-m6lkrehi 4424 9 relatively relatively RB cord-335975-m6lkrehi 4424 10 low low JJ cord-335975-m6lkrehi 4424 11 with with IN cord-335975-m6lkrehi 4424 12 regard regard NN cord-335975-m6lkrehi 4424 13 to to IN cord-335975-m6lkrehi 4424 14 estimated estimate VBN cord-335975-m6lkrehi 4424 15 prognosis prognosis NN cord-335975-m6lkrehi 4424 16 , , , cord-335975-m6lkrehi 4424 17 both both DT cord-335975-m6lkrehi 4424 18 inappropriate inappropriate JJ cord-335975-m6lkrehi 4424 19 care care NN cord-335975-m6lkrehi 4424 20 limitation limitation NN cord-335975-m6lkrehi 4424 21 leading lead VBG cord-335975-m6lkrehi 4424 22 to to IN cord-335975-m6lkrehi 4424 23 self self NN cord-335975-m6lkrehi 4424 24 - - HYPH cord-335975-m6lkrehi 4424 25 fulfilling fulfil VBG cord-335975-m6lkrehi 4424 26 prophecies prophecy NNS cord-335975-m6lkrehi 4424 27 and and CC cord-335975-m6lkrehi 4424 28 unreasonable unreasonable JJ cord-335975-m6lkrehi 4424 29 prolonged prolong VBN cord-335975-m6lkrehi 4424 30 life life NN cord-335975-m6lkrehi 4424 31 supportive supportive JJ cord-335975-m6lkrehi 4424 32 care care NN cord-335975-m6lkrehi 4424 33 could could MD cord-335975-m6lkrehi 4424 34 result result VB cord-335975-m6lkrehi 4424 35 from from IN cord-335975-m6lkrehi 4424 36 these these DT cord-335975-m6lkrehi 4424 37 estimations estimation NNS cord-335975-m6lkrehi 4424 38 . . . cord-335975-m6lkrehi 4425 1 Introduction introduction NN cord-335975-m6lkrehi 4425 2 : : : cord-335975-m6lkrehi 4426 1 Organ organ NN cord-335975-m6lkrehi 4426 2 harvesting harvesting NN cord-335975-m6lkrehi 4426 3 is be VBZ cord-335975-m6lkrehi 4426 4 a a DT cord-335975-m6lkrehi 4426 5 national national JJ cord-335975-m6lkrehi 4426 6 priority priority NN cord-335975-m6lkrehi 4426 7 because because IN cord-335975-m6lkrehi 4426 8 of of IN cord-335975-m6lkrehi 4426 9 the the DT cord-335975-m6lkrehi 4426 10 shortage shortage NN cord-335975-m6lkrehi 4426 11 of of IN cord-335975-m6lkrehi 4426 12 organs organ NNS cord-335975-m6lkrehi 4426 13 , , , cord-335975-m6lkrehi 4426 14 responsible responsible JJ cord-335975-m6lkrehi 4426 15 each each DT cord-335975-m6lkrehi 4426 16 year year NN cord-335975-m6lkrehi 4426 17 for for IN cord-335975-m6lkrehi 4426 18 the the DT cord-335975-m6lkrehi 4426 19 lengthening lengthening NN cord-335975-m6lkrehi 4426 20 of of IN cord-335975-m6lkrehi 4426 21 transplant transplant NN cord-335975-m6lkrehi 4426 22 waiting waiting NN cord-335975-m6lkrehi 4426 23 lists list NNS cord-335975-m6lkrehi 4426 24 . . . cord-335975-m6lkrehi 4427 1 Among among IN cord-335975-m6lkrehi 4427 2 the the DT cord-335975-m6lkrehi 4427 3 identified identify VBN cord-335975-m6lkrehi 4427 4 potential potential JJ cord-335975-m6lkrehi 4427 5 donors donor NNS cord-335975-m6lkrehi 4427 6 , , , cord-335975-m6lkrehi 4427 7 the the DT cord-335975-m6lkrehi 4427 8 main main JJ cord-335975-m6lkrehi 4427 9 cause cause NN cord-335975-m6lkrehi 4427 10 of of IN cord-335975-m6lkrehi 4427 11 non non JJ cord-335975-m6lkrehi 4427 12 - - JJ cord-335975-m6lkrehi 4427 13 harvesting harvesting NN cord-335975-m6lkrehi 4427 14 is be VBZ cord-335975-m6lkrehi 4427 15 the the DT cord-335975-m6lkrehi 4427 16 refusal refusal NN cord-335975-m6lkrehi 4427 17 of of IN cord-335975-m6lkrehi 4427 18 organ organ NN cord-335975-m6lkrehi 4427 19 donation donation NN cord-335975-m6lkrehi 4427 20 ( ( -LRB- cord-335975-m6lkrehi 4427 21 OD OD NNP cord-335975-m6lkrehi 4427 22 ) ) -RRB- cord-335975-m6lkrehi 4427 23 , , , cord-335975-m6lkrehi 4427 24 which which WDT cord-335975-m6lkrehi 4427 25 exceeds exceed VBZ cord-335975-m6lkrehi 4427 26 30 30 CD cord-335975-m6lkrehi 4427 27 % % NN cord-335975-m6lkrehi 4427 28 in in IN cord-335975-m6lkrehi 4427 29 France France NNP cord-335975-m6lkrehi 4427 30 and and CC cord-335975-m6lkrehi 4427 31 40 40 CD cord-335975-m6lkrehi 4427 32 % % NN cord-335975-m6lkrehi 4427 33 in in IN cord-335975-m6lkrehi 4427 34 Paris Paris NNP cord-335975-m6lkrehi 4427 35 area area NN cord-335975-m6lkrehi 4427 36 . . . cord-335975-m6lkrehi 4428 1 Patients patient NNS cord-335975-m6lkrehi 4428 2 and and CC cord-335975-m6lkrehi 4428 3 methods method NNS cord-335975-m6lkrehi 4428 4 : : : cord-335975-m6lkrehi 4428 5 In in IN cord-335975-m6lkrehi 4428 6 a a DT cord-335975-m6lkrehi 4428 7 network network NN cord-335975-m6lkrehi 4428 8 of of IN cord-335975-m6lkrehi 4428 9 6 6 CD cord-335975-m6lkrehi 4428 10 hopitals hopital NNS cord-335975-m6lkrehi 4428 11 , , , cord-335975-m6lkrehi 4428 12 each each DT cord-335975-m6lkrehi 4428 13 procedure procedure NN cord-335975-m6lkrehi 4428 14 on on IN cord-335975-m6lkrehi 4428 15 a a DT cord-335975-m6lkrehi 4428 16 potential potential JJ cord-335975-m6lkrehi 4428 17 donor donor NN cord-335975-m6lkrehi 4428 18 by by IN cord-335975-m6lkrehi 4428 19 the the DT cord-335975-m6lkrehi 4428 20 donor donor NN cord-335975-m6lkrehi 4428 21 co co NN cord-335975-m6lkrehi 4428 22 - - NNP cord-335975-m6lkrehi 4428 23 ordinator ordinator NNP cord-335975-m6lkrehi 4428 24 is be VBZ cord-335975-m6lkrehi 4428 25 recorded record VBN cord-335975-m6lkrehi 4428 26 in in IN cord-335975-m6lkrehi 4428 27 a a DT cord-335975-m6lkrehi 4428 28 report report NN cord-335975-m6lkrehi 4428 29 . . . cord-335975-m6lkrehi 4429 1 After after IN cord-335975-m6lkrehi 4429 2 selection selection NN cord-335975-m6lkrehi 4429 3 of of IN cord-335975-m6lkrehi 4429 4 the the DT cord-335975-m6lkrehi 4429 5 reports report NNS cord-335975-m6lkrehi 4429 6 with with IN cord-335975-m6lkrehi 4429 7 interviews interview NNS cord-335975-m6lkrehi 4429 8 with with IN cord-335975-m6lkrehi 4429 9 relatives relative NNS cord-335975-m6lkrehi 4429 10 about about IN cord-335975-m6lkrehi 4429 11 OD OD NNP cord-335975-m6lkrehi 4429 12 between between IN cord-335975-m6lkrehi 4429 13 2012 2012 CD cord-335975-m6lkrehi 4429 14 and and CC cord-335975-m6lkrehi 4429 15 2015 2015 CD cord-335975-m6lkrehi 4429 16 , , , cord-335975-m6lkrehi 4429 17 the the DT cord-335975-m6lkrehi 4429 18 data datum NNS cord-335975-m6lkrehi 4429 19 in in IN cord-335975-m6lkrehi 4429 20 the the DT cord-335975-m6lkrehi 4429 21 reports report NNS cord-335975-m6lkrehi 4429 22 were be VBD cord-335975-m6lkrehi 4429 23 collected collect VBN cord-335975-m6lkrehi 4429 24 and and CC cord-335975-m6lkrehi 4429 25 a a DT cord-335975-m6lkrehi 4429 26 multivariate multivariate JJ cord-335975-m6lkrehi 4429 27 logistic logistic JJ cord-335975-m6lkrehi 4429 28 regression regression NN cord-335975-m6lkrehi 4429 29 was be VBD cord-335975-m6lkrehi 4429 30 performed perform VBN cord-335975-m6lkrehi 4429 31 to to TO cord-335975-m6lkrehi 4429 32 identify identify VB cord-335975-m6lkrehi 4429 33 the the DT cord-335975-m6lkrehi 4429 34 factors factor NNS cord-335975-m6lkrehi 4429 35 associated associate VBN cord-335975-m6lkrehi 4429 36 with with IN cord-335975-m6lkrehi 4429 37 the the DT cord-335975-m6lkrehi 4429 38 refusal refusal NN cord-335975-m6lkrehi 4429 39 . . . cord-335975-m6lkrehi 4430 1 Results result NNS cord-335975-m6lkrehi 4430 2 : : : cord-335975-m6lkrehi 4430 3 571 571 CD cord-335975-m6lkrehi 4430 4 reports report NNS cord-335975-m6lkrehi 4430 5 with with IN cord-335975-m6lkrehi 4430 6 interviews interview NNS cord-335975-m6lkrehi 4430 7 about about IN cord-335975-m6lkrehi 4430 8 OD OD NNP cord-335975-m6lkrehi 4430 9 was be VBD cord-335975-m6lkrehi 4430 10 found find VBN cord-335975-m6lkrehi 4430 11 . . . cord-335975-m6lkrehi 4431 1 The the DT cord-335975-m6lkrehi 4431 2 overall overall JJ cord-335975-m6lkrehi 4431 3 opposition opposition NN cord-335975-m6lkrehi 4431 4 rate rate NN cord-335975-m6lkrehi 4431 5 is be VBZ cord-335975-m6lkrehi 4431 6 43.3 43.3 CD cord-335975-m6lkrehi 4431 7 % % NN cord-335975-m6lkrehi 4431 8 . . . cord-335975-m6lkrehi 4432 1 Among among IN cord-335975-m6lkrehi 4432 2 the the DT cord-335975-m6lkrehi 4432 3 42 42 CD cord-335975-m6lkrehi 4432 4 children child NNS cord-335975-m6lkrehi 4432 5 ( ( -LRB- cord-335975-m6lkrehi 4432 6 7.3 7.3 CD cord-335975-m6lkrehi 4432 7 % % NN cord-335975-m6lkrehi 4432 8 of of IN cord-335975-m6lkrehi 4432 9 cases case NNS cord-335975-m6lkrehi 4432 10 ) ) -RRB- cord-335975-m6lkrehi 4432 11 the the DT cord-335975-m6lkrehi 4432 12 opposition opposition NN cord-335975-m6lkrehi 4432 13 rate rate NN cord-335975-m6lkrehi 4432 14 is be VBZ cord-335975-m6lkrehi 4432 15 47.6 47.6 CD cord-335975-m6lkrehi 4432 16 % % NN cord-335975-m6lkrehi 4432 17 . . . cord-335975-m6lkrehi 4433 1 Among among IN cord-335975-m6lkrehi 4433 2 adults adult NNS cord-335975-m6lkrehi 4433 3 , , , cord-335975-m6lkrehi 4433 4 147 147 CD cord-335975-m6lkrehi 4433 5 ( ( -LRB- cord-335975-m6lkrehi 4433 6 27.8 27.8 CD cord-335975-m6lkrehi 4433 7 % % NN cord-335975-m6lkrehi 4433 8 ) ) -RRB- cord-335975-m6lkrehi 4433 9 expressed express VBD cord-335975-m6lkrehi 4433 10 their -PRON- PRP$ cord-335975-m6lkrehi 4433 11 will will NN cord-335975-m6lkrehi 4433 12 about about IN cord-335975-m6lkrehi 4433 13 OD OD NNP cord-335975-m6lkrehi 4433 14 during during IN cord-335975-m6lkrehi 4433 15 their -PRON- PRP$ cord-335975-m6lkrehi 4433 16 lifetime lifetime NN cord-335975-m6lkrehi 4433 17 , , , cord-335975-m6lkrehi 4433 18 with with IN cord-335975-m6lkrehi 4433 19 an an DT cord-335975-m6lkrehi 4433 20 opposition opposition NN cord-335975-m6lkrehi 4433 21 rate rate NN cord-335975-m6lkrehi 4433 22 of of IN cord-335975-m6lkrehi 4433 23 43.5 43.5 CD cord-335975-m6lkrehi 4433 24 % % NN cord-335975-m6lkrehi 4433 25 and and CC cord-335975-m6lkrehi 4433 26 for for IN cord-335975-m6lkrehi 4433 27 the the DT cord-335975-m6lkrehi 4433 28 382 382 CD cord-335975-m6lkrehi 4433 29 ( ( -LRB- cord-335975-m6lkrehi 4433 30 72.2 72.2 CD cord-335975-m6lkrehi 4433 31 % % NN cord-335975-m6lkrehi 4433 32 ) ) -RRB- cord-335975-m6lkrehi 4433 33 of of IN cord-335975-m6lkrehi 4433 34 them -PRON- PRP cord-335975-m6lkrehi 4433 35 who who WP cord-335975-m6lkrehi 4433 36 never never RB cord-335975-m6lkrehi 4433 37 expressed express VBD cord-335975-m6lkrehi 4433 38 their -PRON- PRP$ cord-335975-m6lkrehi 4433 39 will will NN cord-335975-m6lkrehi 4433 40 , , , cord-335975-m6lkrehi 4433 41 the the DT cord-335975-m6lkrehi 4433 42 opposition opposition NN cord-335975-m6lkrehi 4433 43 rate rate NN cord-335975-m6lkrehi 4433 44 is be VBZ cord-335975-m6lkrehi 4433 45 42.9 42.9 CD cord-335975-m6lkrehi 4433 46 % % NN cord-335975-m6lkrehi 4433 47 . . . cord-335975-m6lkrehi 4434 1 The the DT cord-335975-m6lkrehi 4434 2 factors factor NNS cord-335975-m6lkrehi 4434 3 associated associate VBN cord-335975-m6lkrehi 4434 4 with with IN cord-335975-m6lkrehi 4434 5 opposition opposition NN cord-335975-m6lkrehi 4434 6 in in IN cord-335975-m6lkrehi 4434 7 multivariate multivariate JJ cord-335975-m6lkrehi 4434 8 analysis analysis NN cord-335975-m6lkrehi 4434 9 are be VBP cord-335975-m6lkrehi 4434 10 presented present VBN cord-335975-m6lkrehi 4434 11 in in IN cord-335975-m6lkrehi 4434 12 Table Table NNP cord-335975-m6lkrehi 4434 13 1 1 CD cord-335975-m6lkrehi 4434 14 . . . cord-335975-m6lkrehi 4435 1 When when WRB cord-335975-m6lkrehi 4435 2 the the DT cord-335975-m6lkrehi 4435 3 deceased deceased JJ cord-335975-m6lkrehi 4435 4 had have VBD cord-335975-m6lkrehi 4435 5 never never RB cord-335975-m6lkrehi 4435 6 expressed express VBN cord-335975-m6lkrehi 4435 7 their -PRON- PRP$ cord-335975-m6lkrehi 4435 8 will will NN cord-335975-m6lkrehi 4435 9 , , , cord-335975-m6lkrehi 4435 10 the the DT cord-335975-m6lkrehi 4435 11 reasons reason NNS cord-335975-m6lkrehi 4435 12 given give VBN cord-335975-m6lkrehi 4435 13 by by IN cord-335975-m6lkrehi 4435 14 the the DT cord-335975-m6lkrehi 4435 15 relatives relative NNS cord-335975-m6lkrehi 4435 16 to to TO cord-335975-m6lkrehi 4435 17 justify justify VB cord-335975-m6lkrehi 4435 18 the the DT cord-335975-m6lkrehi 4435 19 refusal refusal NN cord-335975-m6lkrehi 4435 20 are be VBP cord-335975-m6lkrehi 4435 21 specified specify VBN cord-335975-m6lkrehi 4435 22 in in IN cord-335975-m6lkrehi 4435 23 87.5 87.5 CD cord-335975-m6lkrehi 4435 24 % % NN cord-335975-m6lkrehi 4435 25 of of IN cord-335975-m6lkrehi 4435 26 the the DT cord-335975-m6lkrehi 4435 27 reports report NNS cord-335975-m6lkrehi 4435 28 . . . cord-335975-m6lkrehi 4436 1 These these DT cord-335975-m6lkrehi 4436 2 are be VBP cord-335975-m6lkrehi 4436 3 religious religious JJ cord-335975-m6lkrehi 4436 4 grounds ground NNS cord-335975-m6lkrehi 4436 5 ( ( -LRB- cord-335975-m6lkrehi 4436 6 20 20 CD cord-335975-m6lkrehi 4436 7 % % NN cord-335975-m6lkrehi 4436 8 ) ) -RRB- cord-335975-m6lkrehi 4436 9 , , , cord-335975-m6lkrehi 4436 10 cultural cultural JJ cord-335975-m6lkrehi 4436 11 grounds ground NNS cord-335975-m6lkrehi 4436 12 ( ( -LRB- cord-335975-m6lkrehi 4436 13 12 12 CD cord-335975-m6lkrehi 4436 14 % % NN cord-335975-m6lkrehi 4436 15 ) ) -RRB- cord-335975-m6lkrehi 4436 16 , , , cord-335975-m6lkrehi 4436 17 respect respect NN cord-335975-m6lkrehi 4436 18 for for IN cord-335975-m6lkrehi 4436 19 physical physical JJ cord-335975-m6lkrehi 4436 20 integrity integrity NN cord-335975-m6lkrehi 4436 21 ( ( -LRB- cord-335975-m6lkrehi 4436 22 15 15 CD cord-335975-m6lkrehi 4436 23 % % NN cord-335975-m6lkrehi 4436 24 ) ) -RRB- cord-335975-m6lkrehi 4436 25 . . . cord-335975-m6lkrehi 4437 1 In in IN cord-335975-m6lkrehi 4437 2 18 18 CD cord-335975-m6lkrehi 4437 3 % % NN cord-335975-m6lkrehi 4437 4 of of IN cord-335975-m6lkrehi 4437 5 the the DT cord-335975-m6lkrehi 4437 6 cases case NNS cord-335975-m6lkrehi 4437 7 , , , cord-335975-m6lkrehi 4437 8 relatives relative NNS cord-335975-m6lkrehi 4437 9 believe believe VBP cord-335975-m6lkrehi 4437 10 that that IN cord-335975-m6lkrehi 4437 11 the the DT cord-335975-m6lkrehi 4437 12 deceased deceased JJ cord-335975-m6lkrehi 4437 13 would would MD cord-335975-m6lkrehi 4437 14 have have VB cord-335975-m6lkrehi 4437 15 been be VBN cord-335975-m6lkrehi 4437 16 opposed oppose VBN cord-335975-m6lkrehi 4437 17 , , , cord-335975-m6lkrehi 4437 18 and and CC cord-335975-m6lkrehi 4437 19 in in IN cord-335975-m6lkrehi 4437 20 16 16 CD cord-335975-m6lkrehi 4437 21 % % NN cord-335975-m6lkrehi 4437 22 of of IN cord-335975-m6lkrehi 4437 23 the the DT cord-335975-m6lkrehi 4437 24 cases case NNS cord-335975-m6lkrehi 4437 25 , , , cord-335975-m6lkrehi 4437 26 they -PRON- PRP cord-335975-m6lkrehi 4437 27 choose choose VBP cord-335975-m6lkrehi 4437 28 to to TO cord-335975-m6lkrehi 4437 29 refuse refuse VB cord-335975-m6lkrehi 4437 30 because because IN cord-335975-m6lkrehi 4437 31 they -PRON- PRP cord-335975-m6lkrehi 4437 32 do do VBP cord-335975-m6lkrehi 4437 33 not not RB cord-335975-m6lkrehi 4437 34 know know VB cord-335975-m6lkrehi 4437 35 the the DT cord-335975-m6lkrehi 4437 36 deceased deceased JJ cord-335975-m6lkrehi 4437 37 's 's POS cord-335975-m6lkrehi 4437 38 opinion opinion NN cord-335975-m6lkrehi 4437 39 . . . cord-335975-m6lkrehi 4438 1 Discussion discussion NN cord-335975-m6lkrehi 4438 2 : : : cord-335975-m6lkrehi 4439 1 French french JJ cord-335975-m6lkrehi 4439 2 law law NN cord-335975-m6lkrehi 4439 3 is be VBZ cord-335975-m6lkrehi 4439 4 based base VBN cord-335975-m6lkrehi 4439 5 on on IN cord-335975-m6lkrehi 4439 6 presumed presume VBN cord-335975-m6lkrehi 4439 7 consent consent NN cord-335975-m6lkrehi 4439 8 . . . cord-335975-m6lkrehi 4440 1 Despite despite IN cord-335975-m6lkrehi 4440 2 this this DT cord-335975-m6lkrehi 4440 3 , , , cord-335975-m6lkrehi 4440 4 it -PRON- PRP cord-335975-m6lkrehi 4440 5 is be VBZ cord-335975-m6lkrehi 4440 6 noted note VBN cord-335975-m6lkrehi 4440 7 that that IN cord-335975-m6lkrehi 4440 8 when when WRB cord-335975-m6lkrehi 4440 9 patients patient NNS cord-335975-m6lkrehi 4440 10 had have VBD cord-335975-m6lkrehi 4440 11 never never RB cord-335975-m6lkrehi 4440 12 expressed express VBN cord-335975-m6lkrehi 4440 13 their -PRON- PRP$ cord-335975-m6lkrehi 4440 14 opinion opinion NN cord-335975-m6lkrehi 4440 15 about about IN cord-335975-m6lkrehi 4440 16 OD OD NNP cord-335975-m6lkrehi 4440 17 ( ( -LRB- cord-335975-m6lkrehi 4440 18 and and CC cord-335975-m6lkrehi 4440 19 therefore therefore RB cord-335975-m6lkrehi 4440 20 had have VBD cord-335975-m6lkrehi 4440 21 not not RB cord-335975-m6lkrehi 4440 22 refused refuse VBN cord-335975-m6lkrehi 4440 23 it -PRON- PRP cord-335975-m6lkrehi 4440 24 ) ) -RRB- cord-335975-m6lkrehi 4440 25 , , , cord-335975-m6lkrehi 4440 26 the the DT cord-335975-m6lkrehi 4440 27 opposition opposition NN cord-335975-m6lkrehi 4440 28 rate rate NN cord-335975-m6lkrehi 4440 29 reached reach VBD cord-335975-m6lkrehi 4440 30 43.5 43.5 CD cord-335975-m6lkrehi 4440 31 % % NN cord-335975-m6lkrehi 4440 32 and and CC cord-335975-m6lkrehi 4440 33 was be VBD cord-335975-m6lkrehi 4440 34 comparable comparable JJ cord-335975-m6lkrehi 4440 35 to to IN cord-335975-m6lkrehi 4440 36 the the DT cord-335975-m6lkrehi 4440 37 patients patient NNS cord-335975-m6lkrehi 4440 38 who who WP cord-335975-m6lkrehi 4440 39 had have VBD cord-335975-m6lkrehi 4440 40 expressed express VBN cord-335975-m6lkrehi 4440 41 themselves -PRON- PRP cord-335975-m6lkrehi 4440 42 . . . cord-335975-m6lkrehi 4441 1 Conclusion conclusion NN cord-335975-m6lkrehi 4441 2 : : : cord-335975-m6lkrehi 4442 1 In in IN cord-335975-m6lkrehi 4442 2 our -PRON- PRP$ cord-335975-m6lkrehi 4442 3 study study NN cord-335975-m6lkrehi 4442 4 , , , cord-335975-m6lkrehi 4442 5 factors factor NNS cord-335975-m6lkrehi 4442 6 related relate VBN cord-335975-m6lkrehi 4442 7 to to IN cord-335975-m6lkrehi 4442 8 refusal refusal NN cord-335975-m6lkrehi 4442 9 of of IN cord-335975-m6lkrehi 4442 10 OD OD NNP cord-335975-m6lkrehi 4442 11 are be VBP cord-335975-m6lkrehi 4442 12 mainly mainly RB cord-335975-m6lkrehi 4442 13 related relate VBN cord-335975-m6lkrehi 4442 14 to to IN cord-335975-m6lkrehi 4442 15 the the DT cord-335975-m6lkrehi 4442 16 characteristics characteristic NNS cord-335975-m6lkrehi 4442 17 of of IN cord-335975-m6lkrehi 4442 18 the the DT cord-335975-m6lkrehi 4442 19 deceased deceased JJ cord-335975-m6lkrehi 4442 20 ( ( -LRB- cord-335975-m6lkrehi 4442 21 religion religion NN cord-335975-m6lkrehi 4442 22 , , , cord-335975-m6lkrehi 4442 23 culture culture NN cord-335975-m6lkrehi 4442 24 , , , cord-335975-m6lkrehi 4442 25 history history NN cord-335975-m6lkrehi 4442 26 of of IN cord-335975-m6lkrehi 4442 27 ethylism ethylism NN cord-335975-m6lkrehi 4442 28 ) ) -RRB- cord-335975-m6lkrehi 4442 29 and and CC cord-335975-m6lkrehi 4442 30 those those DT cord-335975-m6lkrehi 4442 31 of of IN cord-335975-m6lkrehi 4442 32 relatives relative NNS cord-335975-m6lkrehi 4442 33 ( ( -LRB- cord-335975-m6lkrehi 4442 34 disagreement disagreement NN cord-335975-m6lkrehi 4442 35 , , , cord-335975-m6lkrehi 4442 36 presence presence NN cord-335975-m6lkrehi 4442 37 of of IN cord-335975-m6lkrehi 4442 38 a a DT cord-335975-m6lkrehi 4442 39 spouse spouse NN cord-335975-m6lkrehi 4442 40 ) ) -RRB- cord-335975-m6lkrehi 4442 41 , , , cord-335975-m6lkrehi 4442 42 but but CC cord-335975-m6lkrehi 4442 43 little little JJ cord-335975-m6lkrehi 4442 44 to to IN cord-335975-m6lkrehi 4442 45 the the DT cord-335975-m6lkrehi 4442 46 way way NN cord-335975-m6lkrehi 4442 47 of of IN cord-335975-m6lkrehi 4442 48 doing do VBG cord-335975-m6lkrehi 4442 49 the the DT cord-335975-m6lkrehi 4442 50 interview interview NN cord-335975-m6lkrehi 4442 51 . . . cord-335975-m6lkrehi 4443 1 However however RB cord-335975-m6lkrehi 4443 2 , , , cord-335975-m6lkrehi 4443 3 there there EX cord-335975-m6lkrehi 4443 4 is be VBZ cord-335975-m6lkrehi 4443 5 a a DT cord-335975-m6lkrehi 4443 6 trend trend NN cord-335975-m6lkrehi 4443 7 for for IN cord-335975-m6lkrehi 4443 8 less less JJR cord-335975-m6lkrehi 4443 9 opposition opposition NN cord-335975-m6lkrehi 4443 10 when when WRB cord-335975-m6lkrehi 4443 11 the the DT cord-335975-m6lkrehi 4443 12 interview interview NN cord-335975-m6lkrehi 4443 13 is be VBZ cord-335975-m6lkrehi 4443 14 conducted conduct VBN cord-335975-m6lkrehi 4443 15 during during IN cord-335975-m6lkrehi 4443 16 the the DT cord-335975-m6lkrehi 4443 17 day day NN cord-335975-m6lkrehi 4443 18 ( ( -LRB- cord-335975-m6lkrehi 4443 19 between between IN cord-335975-m6lkrehi 4443 20 8 8 CD cord-335975-m6lkrehi 4443 21 - - SYM cord-335975-m6lkrehi 4443 22 00 00 CD cord-335975-m6lkrehi 4443 23 and and CC cord-335975-m6lkrehi 4443 24 20 20 CD cord-335975-m6lkrehi 4443 25 - - SYM cord-335975-m6lkrehi 4443 26 00 00 CD cord-335975-m6lkrehi 4443 27 ) ) -RRB- cord-335975-m6lkrehi 4443 28 . . . cord-335975-m6lkrehi 4444 1 On on IN cord-335975-m6lkrehi 4444 2 the the DT cord-335975-m6lkrehi 4444 3 other other JJ cord-335975-m6lkrehi 4444 4 hand hand NN cord-335975-m6lkrehi 4444 5 , , , cord-335975-m6lkrehi 4444 6 when when WRB cord-335975-m6lkrehi 4444 7 relatives relative NNS cord-335975-m6lkrehi 4444 8 first first RB cord-335975-m6lkrehi 4444 9 address address VBP cord-335975-m6lkrehi 4444 10 the the DT cord-335975-m6lkrehi 4444 11 issue issue NN cord-335975-m6lkrehi 4444 12 of of IN cord-335975-m6lkrehi 4444 13 OD OD NNP cord-335975-m6lkrehi 4444 14 , , , cord-335975-m6lkrehi 4444 15 the the DT cord-335975-m6lkrehi 4444 16 opposition opposition NN cord-335975-m6lkrehi 4444 17 rate rate NN cord-335975-m6lkrehi 4444 18 is be VBZ cord-335975-m6lkrehi 4444 19 lower low JJR cord-335975-m6lkrehi 4444 20 . . . cord-335975-m6lkrehi 4445 1 Introduction introduction NN cord-335975-m6lkrehi 4445 2 : : : cord-335975-m6lkrehi 4445 3 French french JJ cord-335975-m6lkrehi 4445 4 intensive intensive JJ cord-335975-m6lkrehi 4445 5 care care NN cord-335975-m6lkrehi 4445 6 society society NN cord-335975-m6lkrehi 4445 7 guidelines guideline NNS cord-335975-m6lkrehi 4445 8 and and CC cord-335975-m6lkrehi 4445 9 the the DT cord-335975-m6lkrehi 4445 10 Claes Claes NNP cord-335975-m6lkrehi 4445 11 - - HYPH cord-335975-m6lkrehi 4445 12 Leonnetti Leonnetti NNP cord-335975-m6lkrehi 4445 13 Law Law NNP cord-335975-m6lkrehi 4445 14 recommend recommend VBP cord-335975-m6lkrehi 4445 15 that that DT cord-335975-m6lkrehi 4445 16 intensive intensive JJ cord-335975-m6lkrehi 4445 17 care care NN cord-335975-m6lkrehi 4445 18 teams team NNS cord-335975-m6lkrehi 4445 19 organize organize VBP cord-335975-m6lkrehi 4445 20 collegiate collegiate JJ cord-335975-m6lkrehi 4445 21 and and CC cord-335975-m6lkrehi 4445 22 multidisciplinary multidisciplinary JJ cord-335975-m6lkrehi 4445 23 discussions discussion NNS cord-335975-m6lkrehi 4445 24 regarding regard VBG cord-335975-m6lkrehi 4445 25 limitation limitation NN cord-335975-m6lkrehi 4445 26 and and CC cord-335975-m6lkrehi 4445 27 withdrawal withdrawal NN cord-335975-m6lkrehi 4445 28 of of IN cord-335975-m6lkrehi 4445 29 care care NN cord-335975-m6lkrehi 4445 30 decisions decision NNS cord-335975-m6lkrehi 4445 31 . . . cord-335975-m6lkrehi 4446 1 These these DT cord-335975-m6lkrehi 4446 2 moments moment NNS cord-335975-m6lkrehi 4446 3 , , , cord-335975-m6lkrehi 4446 4 coined coin VBD cord-335975-m6lkrehi 4446 5 ethical ethical JJ cord-335975-m6lkrehi 4446 6 staffs staff NNS cord-335975-m6lkrehi 4446 7 in in IN cord-335975-m6lkrehi 4446 8 our -PRON- PRP$ cord-335975-m6lkrehi 4446 9 unit unit NN cord-335975-m6lkrehi 4446 10 , , , cord-335975-m6lkrehi 4446 11 require require VBP cord-335975-m6lkrehi 4446 12 freedom freedom NN cord-335975-m6lkrehi 4446 13 and and CC cord-335975-m6lkrehi 4446 14 safety safety NN cord-335975-m6lkrehi 4446 15 of of IN cord-335975-m6lkrehi 4446 16 speech speech NN cord-335975-m6lkrehi 4446 17 , , , cord-335975-m6lkrehi 4446 18 which which WDT cord-335975-m6lkrehi 4446 19 can can MD cord-335975-m6lkrehi 4446 20 be be VB cord-335975-m6lkrehi 4446 21 difficult difficult JJ cord-335975-m6lkrehi 4446 22 to to TO cord-335975-m6lkrehi 4446 23 obtain obtain VB cord-335975-m6lkrehi 4446 24 when when WRB cord-335975-m6lkrehi 4446 25 people people NNS cord-335975-m6lkrehi 4446 26 are be VBP cord-335975-m6lkrehi 4446 27 caught catch VBN cord-335975-m6lkrehi 4446 28 in in IN cord-335975-m6lkrehi 4446 29 hierarchical hierarchical JJ cord-335975-m6lkrehi 4446 30 and and CC cord-335975-m6lkrehi 4446 31 or or CC cord-335975-m6lkrehi 4446 32 power power NN cord-335975-m6lkrehi 4446 33 relations relation NNS cord-335975-m6lkrehi 4446 34 . . . cord-335975-m6lkrehi 4447 1 We -PRON- PRP cord-335975-m6lkrehi 4447 2 sought seek VBD cord-335975-m6lkrehi 4447 3 to to TO cord-335975-m6lkrehi 4447 4 assess assess VB cord-335975-m6lkrehi 4447 5 the the DT cord-335975-m6lkrehi 4447 6 representations representation NNS cord-335975-m6lkrehi 4447 7 , , , cord-335975-m6lkrehi 4447 8 perceptions perception NNS cord-335975-m6lkrehi 4447 9 and and CC cord-335975-m6lkrehi 4447 10 opinions opinion NNS cord-335975-m6lkrehi 4447 11 of of IN cord-335975-m6lkrehi 4447 12 ICU ICU NNP cord-335975-m6lkrehi 4447 13 personnel personnel NNS cord-335975-m6lkrehi 4447 14 regarding regard VBG cord-335975-m6lkrehi 4447 15 ethical ethical JJ cord-335975-m6lkrehi 4447 16 staffs staff NNS cord-335975-m6lkrehi 4447 17 . . . cord-335975-m6lkrehi 4448 1 Patients patient NNS cord-335975-m6lkrehi 4448 2 and and CC cord-335975-m6lkrehi 4448 3 methods method NNS cord-335975-m6lkrehi 4448 4 : : : cord-335975-m6lkrehi 4448 5 A a DT cord-335975-m6lkrehi 4448 6 questionnaire questionnaire NN cord-335975-m6lkrehi 4448 7 , , , cord-335975-m6lkrehi 4448 8 developed develop VBN cord-335975-m6lkrehi 4448 9 by by IN cord-335975-m6lkrehi 4448 10 the the DT cord-335975-m6lkrehi 4448 11 ICU ICU NNP cord-335975-m6lkrehi 4448 12 psychologist psychologist NN cord-335975-m6lkrehi 4448 13 , , , cord-335975-m6lkrehi 4448 14 was be VBD cord-335975-m6lkrehi 4448 15 distributed distribute VBN cord-335975-m6lkrehi 4448 16 to to IN cord-335975-m6lkrehi 4448 17 the the DT cord-335975-m6lkrehi 4448 18 entire entire JJ cord-335975-m6lkrehi 4448 19 unit unit NN cord-335975-m6lkrehi 4448 20 ( ( -LRB- cord-335975-m6lkrehi 4448 21 secretaries secretary NNS cord-335975-m6lkrehi 4448 22 , , , cord-335975-m6lkrehi 4448 23 nurses nurse NNS cord-335975-m6lkrehi 4448 24 , , , cord-335975-m6lkrehi 4448 25 nursing nursing NN cord-335975-m6lkrehi 4448 26 auxiliaries auxiliary NNS cord-335975-m6lkrehi 4448 27 , , , cord-335975-m6lkrehi 4448 28 doctors doctor NNS cord-335975-m6lkrehi 4448 29 ) ) -RRB- cord-335975-m6lkrehi 4448 30 over over IN cord-335975-m6lkrehi 4448 31 a a DT cord-335975-m6lkrehi 4448 32 period period NN cord-335975-m6lkrehi 4448 33 of of IN cord-335975-m6lkrehi 4448 34 6 6 CD cord-335975-m6lkrehi 4448 35 months month NNS cord-335975-m6lkrehi 4448 36 . . . cord-335975-m6lkrehi 4449 1 This this DT cord-335975-m6lkrehi 4449 2 30-question 30-question CD cord-335975-m6lkrehi 4449 3 questionnaire questionnaire NN cord-335975-m6lkrehi 4449 4 covered cover VBN cord-335975-m6lkrehi 4449 5 session session NN cord-335975-m6lkrehi 4449 6 organization organization NN cord-335975-m6lkrehi 4449 7 and and CC cord-335975-m6lkrehi 4449 8 power power NN cord-335975-m6lkrehi 4449 9 relations relation NNS cord-335975-m6lkrehi 4449 10 between between IN cord-335975-m6lkrehi 4449 11 participants participant NNS cord-335975-m6lkrehi 4449 12 . . . cord-335975-m6lkrehi 4450 1 Results result NNS cord-335975-m6lkrehi 4450 2 : : : cord-335975-m6lkrehi 4451 1 Among among IN cord-335975-m6lkrehi 4451 2 the the DT cord-335975-m6lkrehi 4451 3 86 86 CD cord-335975-m6lkrehi 4451 4 questionnaires questionnaire NNS cord-335975-m6lkrehi 4451 5 distributed distribute VBN cord-335975-m6lkrehi 4451 6 in in IN cord-335975-m6lkrehi 4451 7 the the DT cord-335975-m6lkrehi 4451 8 ICU ICU NNP cord-335975-m6lkrehi 4451 9 , , , cord-335975-m6lkrehi 4451 10 76 76 CD cord-335975-m6lkrehi 4451 11 were be VBD cord-335975-m6lkrehi 4451 12 retrieved retrieve VBN cord-335975-m6lkrehi 4451 13 and and CC cord-335975-m6lkrehi 4451 14 analyzed analyze VBN cord-335975-m6lkrehi 4451 15 . . . cord-335975-m6lkrehi 4452 1 Medical medical JJ cord-335975-m6lkrehi 4452 2 function function NN cord-335975-m6lkrehi 4452 3 was be VBD cord-335975-m6lkrehi 4452 4 associated associate VBN cord-335975-m6lkrehi 4452 5 by by IN cord-335975-m6lkrehi 4452 6 respondents respondent NNS cord-335975-m6lkrehi 4452 7 with with IN cord-335975-m6lkrehi 4452 8 roles role NNS cord-335975-m6lkrehi 4452 9 linked link VBN cord-335975-m6lkrehi 4452 10 with with IN cord-335975-m6lkrehi 4452 11 power power NN cord-335975-m6lkrehi 4452 12 ( ( -LRB- cord-335975-m6lkrehi 4452 13 leading leading NN cord-335975-m6lkrehi 4452 14 , , , cord-335975-m6lkrehi 4452 15 knowledge knowledge NN cord-335975-m6lkrehi 4452 16 , , , cord-335975-m6lkrehi 4452 17 decision decision NN cord-335975-m6lkrehi 4452 18 , , , cord-335975-m6lkrehi 4452 19 explanation explanation NN cord-335975-m6lkrehi 4452 20 ) ) -RRB- cord-335975-m6lkrehi 4452 21 whereas whereas IN cord-335975-m6lkrehi 4452 22 paramedical paramedical JJ cord-335975-m6lkrehi 4452 23 function function NN cord-335975-m6lkrehi 4452 24 was be VBD cord-335975-m6lkrehi 4452 25 associated associate VBN cord-335975-m6lkrehi 4452 26 with with IN cord-335975-m6lkrehi 4452 27 roles role NNS cord-335975-m6lkrehi 4452 28 linked link VBN cord-335975-m6lkrehi 4452 29 with with IN cord-335975-m6lkrehi 4452 30 care care NN cord-335975-m6lkrehi 4452 31 ( ( -LRB- cord-335975-m6lkrehi 4452 32 perception perception NN cord-335975-m6lkrehi 4452 33 , , , cord-335975-m6lkrehi 4452 34 account account NN cord-335975-m6lkrehi 4452 35 , , , cord-335975-m6lkrehi 4452 36 spokesperson spokesperson NN cord-335975-m6lkrehi 4452 37 ) ) -RRB- cord-335975-m6lkrehi 4453 1 ( ( -LRB- cord-335975-m6lkrehi 4453 2 Fig Fig NNP cord-335975-m6lkrehi 4453 3 . . NNP cord-335975-m6lkrehi 4453 4 1 1 CD cord-335975-m6lkrehi 4453 5 ) ) -RRB- cord-335975-m6lkrehi 4453 6 . . . cord-335975-m6lkrehi 4454 1 Regarding regard VBG cord-335975-m6lkrehi 4454 2 representations representation NNS cord-335975-m6lkrehi 4454 3 of of IN cord-335975-m6lkrehi 4454 4 decision decision NN cord-335975-m6lkrehi 4454 5 making making NN cord-335975-m6lkrehi 4454 6 , , , cord-335975-m6lkrehi 4454 7 nurses nurse NNS cord-335975-m6lkrehi 4454 8 were be VBD cord-335975-m6lkrehi 4454 9 considered consider VBN cord-335975-m6lkrehi 4454 10 as as IN cord-335975-m6lkrehi 4454 11 decision decision NN cord-335975-m6lkrehi 4454 12 makers maker NNS cord-335975-m6lkrehi 4454 13 in in IN cord-335975-m6lkrehi 4454 14 48 48 CD cord-335975-m6lkrehi 4454 15 cases case NNS cord-335975-m6lkrehi 4454 16 ( ( -LRB- cord-335975-m6lkrehi 4454 17 63 63 CD cord-335975-m6lkrehi 4454 18 % % NN cord-335975-m6lkrehi 4454 19 ) ) -RRB- cord-335975-m6lkrehi 4454 20 and and CC cord-335975-m6lkrehi 4454 21 doctors doctor NNS cord-335975-m6lkrehi 4454 22 in in IN cord-335975-m6lkrehi 4454 23 76 76 CD cord-335975-m6lkrehi 4454 24 cases case NNS cord-335975-m6lkrehi 4454 25 ( ( -LRB- cord-335975-m6lkrehi 4454 26 100 100 CD cord-335975-m6lkrehi 4454 27 % % NN cord-335975-m6lkrehi 4454 28 ) ) -RRB- cord-335975-m6lkrehi 4454 29 . . . cord-335975-m6lkrehi 4455 1 Discussion discussion NN cord-335975-m6lkrehi 4455 2 : : : cord-335975-m6lkrehi 4456 1 Although although IN cord-335975-m6lkrehi 4456 2 ethical ethical JJ cord-335975-m6lkrehi 4456 3 staffs staff NNS cord-335975-m6lkrehi 4456 4 are be VBP cord-335975-m6lkrehi 4456 5 presented present VBN cord-335975-m6lkrehi 4456 6 as as IN cord-335975-m6lkrehi 4456 7 a a DT cord-335975-m6lkrehi 4456 8 place place NN cord-335975-m6lkrehi 4456 9 where where WRB cord-335975-m6lkrehi 4456 10 each each DT cord-335975-m6lkrehi 4456 11 opinion opinion NN cord-335975-m6lkrehi 4456 12 counts count VBZ cord-335975-m6lkrehi 4456 13 , , , cord-335975-m6lkrehi 4456 14 stereotypes stereotype NNS cord-335975-m6lkrehi 4456 15 representation representation NN cord-335975-m6lkrehi 4456 16 appear appear VBP cord-335975-m6lkrehi 4456 17 in in IN cord-335975-m6lkrehi 4456 18 the the DT cord-335975-m6lkrehi 4456 19 different different JJ cord-335975-m6lkrehi 4456 20 roles role NNS cord-335975-m6lkrehi 4456 21 assigned assign VBN cord-335975-m6lkrehi 4456 22 - - HYPH cord-335975-m6lkrehi 4456 23 on on RP cord-335975-m6lkrehi 4456 24 one one CD cord-335975-m6lkrehi 4456 25 side side NN cord-335975-m6lkrehi 4456 26 doctors doctor NNS cord-335975-m6lkrehi 4456 27 are be VBP cord-335975-m6lkrehi 4456 28 in in IN cord-335975-m6lkrehi 4456 29 charge charge NN cord-335975-m6lkrehi 4456 30 of of IN cord-335975-m6lkrehi 4456 31 explanation explanation NN cord-335975-m6lkrehi 4456 32 and and CC cord-335975-m6lkrehi 4456 33 decision decision NN cord-335975-m6lkrehi 4456 34 , , , cord-335975-m6lkrehi 4456 35 and and CC cord-335975-m6lkrehi 4456 36 on on IN cord-335975-m6lkrehi 4456 37 the the DT cord-335975-m6lkrehi 4456 38 other other JJ cord-335975-m6lkrehi 4456 39 side side NN cord-335975-m6lkrehi 4456 40 , , , cord-335975-m6lkrehi 4456 41 nurses nurse NNS cord-335975-m6lkrehi 4456 42 are be VBP cord-335975-m6lkrehi 4456 43 taking take VBG cord-335975-m6lkrehi 4456 44 care care NN cord-335975-m6lkrehi 4456 45 of of IN cord-335975-m6lkrehi 4456 46 patient patient NN cord-335975-m6lkrehi 4456 47 's 's POS cord-335975-m6lkrehi 4456 48 feelings feeling NNS cord-335975-m6lkrehi 4456 49 and and CC cord-335975-m6lkrehi 4456 50 assume assume VB cord-335975-m6lkrehi 4456 51 a a DT cord-335975-m6lkrehi 4456 52 role role NN cord-335975-m6lkrehi 4456 53 of of IN cord-335975-m6lkrehi 4456 54 spokesperson spokesperson NN cord-335975-m6lkrehi 4456 55 . . . cord-335975-m6lkrehi 4457 1 These these DT cord-335975-m6lkrehi 4457 2 stereotypes stereotype NNS cord-335975-m6lkrehi 4457 3 correspond correspond VBP cord-335975-m6lkrehi 4457 4 to to IN cord-335975-m6lkrehi 4457 5 gender gender NN cord-335975-m6lkrehi 4457 6 stereotypes stereotype NNS cord-335975-m6lkrehi 4457 7 assigning assign VBG cord-335975-m6lkrehi 4457 8 women woman NNS cord-335975-m6lkrehi 4457 9 to to IN cord-335975-m6lkrehi 4457 10 positions position NNS cord-335975-m6lkrehi 4457 11 of of IN cord-335975-m6lkrehi 4457 12 care care NN cord-335975-m6lkrehi 4457 13 , , , cord-335975-m6lkrehi 4457 14 empathy empathy NN cord-335975-m6lkrehi 4457 15 and and CC cord-335975-m6lkrehi 4457 16 relationship relationship NN cord-335975-m6lkrehi 4457 17 , , , cord-335975-m6lkrehi 4457 18 and and CC cord-335975-m6lkrehi 4457 19 men man NNS cord-335975-m6lkrehi 4457 20 to to IN cord-335975-m6lkrehi 4457 21 more more RBR cord-335975-m6lkrehi 4457 22 intellectual intellectual JJ cord-335975-m6lkrehi 4457 23 and and CC cord-335975-m6lkrehi 4457 24 leading leading JJ cord-335975-m6lkrehi 4457 25 skills skill NNS cord-335975-m6lkrehi 4457 26 . . . cord-335975-m6lkrehi 4458 1 These these DT cord-335975-m6lkrehi 4458 2 gender gender NN cord-335975-m6lkrehi 4458 3 stereotypes stereotype NNS cord-335975-m6lkrehi 4458 4 attest attest VBP cord-335975-m6lkrehi 4458 5 a a DT cord-335975-m6lkrehi 4458 6 hierarchy hierarchy NN cord-335975-m6lkrehi 4458 7 internalized internalize VBN cord-335975-m6lkrehi 4458 8 by by IN cord-335975-m6lkrehi 4458 9 each each DT cord-335975-m6lkrehi 4458 10 one one NN cord-335975-m6lkrehi 4458 11 , , , cord-335975-m6lkrehi 4458 12 as as IN cord-335975-m6lkrehi 4458 13 highlighted highlight VBN cord-335975-m6lkrehi 4458 14 by by IN cord-335975-m6lkrehi 4458 15 social social JJ cord-335975-m6lkrehi 4458 16 sciences sciences NNPS cord-335975-m6lkrehi 4458 17 and and CC cord-335975-m6lkrehi 4458 18 gender gender NN cord-335975-m6lkrehi 4458 19 studies study NNS cord-335975-m6lkrehi 4458 20 . . . cord-335975-m6lkrehi 4459 1 Conclusion conclusion NN cord-335975-m6lkrehi 4459 2 : : : cord-335975-m6lkrehi 4460 1 Our -PRON- PRP$ cord-335975-m6lkrehi 4460 2 results result NNS cord-335975-m6lkrehi 4460 3 highlight highlight VBP cord-335975-m6lkrehi 4460 4 the the DT cord-335975-m6lkrehi 4460 5 existence existence NN cord-335975-m6lkrehi 4460 6 of of IN cord-335975-m6lkrehi 4460 7 a a DT cord-335975-m6lkrehi 4460 8 global global JJ cord-335975-m6lkrehi 4460 9 idea idea NN cord-335975-m6lkrehi 4460 10 , , , cord-335975-m6lkrehi 4460 11 shared share VBN cord-335975-m6lkrehi 4460 12 by by IN cord-335975-m6lkrehi 4460 13 the the DT cord-335975-m6lkrehi 4460 14 majority majority NN cord-335975-m6lkrehi 4460 15 - - HYPH cord-335975-m6lkrehi 4460 16 doctors doctor NNS cord-335975-m6lkrehi 4460 17 are be VBP cord-335975-m6lkrehi 4460 18 decision decision NN cord-335975-m6lkrehi 4460 19 makers maker NNS cord-335975-m6lkrehi 4460 20 and and CC cord-335975-m6lkrehi 4460 21 therefore therefore RB cord-335975-m6lkrehi 4460 22 are be VBP cord-335975-m6lkrehi 4460 23 in in IN cord-335975-m6lkrehi 4460 24 a a DT cord-335975-m6lkrehi 4460 25 power power NN cord-335975-m6lkrehi 4460 26 relation relation NN cord-335975-m6lkrehi 4460 27 regarding regard VBG cord-335975-m6lkrehi 4460 28 paramedical paramedical JJ cord-335975-m6lkrehi 4460 29 staff staff NN cord-335975-m6lkrehi 4460 30 . . . cord-335975-m6lkrehi 4461 1 This this DT cord-335975-m6lkrehi 4461 2 hierarchical hierarchical JJ cord-335975-m6lkrehi 4461 3 relationship relationship NN cord-335975-m6lkrehi 4461 4 persists persist VBZ cord-335975-m6lkrehi 4461 5 in in IN cord-335975-m6lkrehi 4461 6 this this DT cord-335975-m6lkrehi 4461 7 moment moment NN cord-335975-m6lkrehi 4461 8 wished wish VBD cord-335975-m6lkrehi 4461 9 egalitarian egalitarian JJ cord-335975-m6lkrehi 4461 10 ( ( -LRB- cord-335975-m6lkrehi 4461 11 each each DT cord-335975-m6lkrehi 4461 12 opinion opinion NN cord-335975-m6lkrehi 4461 13 would would MD cord-335975-m6lkrehi 4461 14 count count VB cord-335975-m6lkrehi 4461 15 equally equally RB cord-335975-m6lkrehi 4461 16 ) ) -RRB- cord-335975-m6lkrehi 4461 17 . . . cord-335975-m6lkrehi 4462 1 These these DT cord-335975-m6lkrehi 4462 2 is be VBZ cord-335975-m6lkrehi 4462 3 a a DT cord-335975-m6lkrehi 4462 4 linkage linkage NN cord-335975-m6lkrehi 4462 5 between between IN cord-335975-m6lkrehi 4462 6 professional professional JJ cord-335975-m6lkrehi 4462 7 power power NN cord-335975-m6lkrehi 4462 8 relations relation NNS cord-335975-m6lkrehi 4462 9 and and CC cord-335975-m6lkrehi 4462 10 gender gender NN cord-335975-m6lkrehi 4462 11 power power NN cord-335975-m6lkrehi 4462 12 relations relation NNS cord-335975-m6lkrehi 4462 13 , , , cord-335975-m6lkrehi 4462 14 which which WDT cord-335975-m6lkrehi 4462 15 show show VBP cord-335975-m6lkrehi 4462 16 an an DT cord-335975-m6lkrehi 4462 17 association association NN cord-335975-m6lkrehi 4462 18 between between IN cord-335975-m6lkrehi 4462 19 doctor doctor NN cord-335975-m6lkrehi 4462 20 and and CC cord-335975-m6lkrehi 4462 21 masculine masculine JJ cord-335975-m6lkrehi 4462 22 " " `` cord-335975-m6lkrehi 4462 23 qualities quality NNS cord-335975-m6lkrehi 4462 24 " " '' cord-335975-m6lkrehi 4462 25 and and CC cord-335975-m6lkrehi 4462 26 caretakers caretaker NNS cord-335975-m6lkrehi 4462 27 and and CC cord-335975-m6lkrehi 4462 28 feminine feminine JJ cord-335975-m6lkrehi 4462 29 " " `` cord-335975-m6lkrehi 4462 30 qualities quality NNS cord-335975-m6lkrehi 4462 31 " " '' cord-335975-m6lkrehi 4462 32 . . . cord-335975-m6lkrehi 4463 1 These these DT cord-335975-m6lkrehi 4463 2 power power NN cord-335975-m6lkrehi 4463 3 relations relation NNS cord-335975-m6lkrehi 4463 4 are be VBP cord-335975-m6lkrehi 4463 5 rarely rarely RB cord-335975-m6lkrehi 4463 6 acknowledged acknowledge VBN cord-335975-m6lkrehi 4463 7 but but CC cord-335975-m6lkrehi 4463 8 could could MD cord-335975-m6lkrehi 4463 9 have have VB cord-335975-m6lkrehi 4463 10 a a DT cord-335975-m6lkrehi 4463 11 significant significant JJ cord-335975-m6lkrehi 4463 12 impact impact NN cord-335975-m6lkrehi 4463 13 on on IN cord-335975-m6lkrehi 4463 14 the the DT cord-335975-m6lkrehi 4463 15 decision decision NN cord-335975-m6lkrehi 4463 16 process process NN cord-335975-m6lkrehi 4463 17 of of IN cord-335975-m6lkrehi 4463 18 these these DT cord-335975-m6lkrehi 4463 19 meetings meeting NNS cord-335975-m6lkrehi 4463 20 , , , cord-335975-m6lkrehi 4463 21 and and CC cord-335975-m6lkrehi 4463 22 should should MD cord-335975-m6lkrehi 4463 23 be be VB cord-335975-m6lkrehi 4463 24 further further RB cord-335975-m6lkrehi 4463 25 investigated investigate VBN cord-335975-m6lkrehi 4463 26 . . . cord-335975-m6lkrehi 4464 1 results result NNS cord-335975-m6lkrehi 4464 2 . . . cord-335975-m6lkrehi 4465 1 Despite despite IN cord-335975-m6lkrehi 4465 2 the the DT cord-335975-m6lkrehi 4465 3 diary diary NN cord-335975-m6lkrehi 4465 4 , , , cord-335975-m6lkrehi 4465 5 33 33 CD cord-335975-m6lkrehi 4465 6 % % NN cord-335975-m6lkrehi 4465 7 had have VBD cord-335975-m6lkrehi 4465 8 a a DT cord-335975-m6lkrehi 4465 9 QSPT QSPT NNP cord-335975-m6lkrehi 4465 10 score score NN cord-335975-m6lkrehi 4466 1 > > XX cord-335975-m6lkrehi 4467 1 51 51 CD cord-335975-m6lkrehi 4467 2 , , , cord-335975-m6lkrehi 4467 3 indicating indicate VBG cord-335975-m6lkrehi 4467 4 a a DT cord-335975-m6lkrehi 4467 5 higher high JJR cord-335975-m6lkrehi 4467 6 post post JJ cord-335975-m6lkrehi 4467 7 traumatic traumatic JJ cord-335975-m6lkrehi 4467 8 disorders disorder NNS cord-335975-m6lkrehi 4467 9 . . . cord-335975-m6lkrehi 4468 1 9 9 CD cord-335975-m6lkrehi 4468 2 patients patient NNS cord-335975-m6lkrehi 4468 3 ( ( -LRB- cord-335975-m6lkrehi 4468 4 25 25 CD cord-335975-m6lkrehi 4468 5 % % NN cord-335975-m6lkrehi 4468 6 ) ) -RRB- cord-335975-m6lkrehi 4468 7 presented present VBD cord-335975-m6lkrehi 4468 8 a a DT cord-335975-m6lkrehi 4468 9 anxiety anxiety NN cord-335975-m6lkrehi 4468 10 score score NN cord-335975-m6lkrehi 4468 11 > > XX cord-335975-m6lkrehi 4468 12 11 11 CD cord-335975-m6lkrehi 4468 13 and and CC cord-335975-m6lkrehi 4468 14 11 11 CD cord-335975-m6lkrehi 4468 15 patients patient NNS cord-335975-m6lkrehi 4468 16 ( ( -LRB- cord-335975-m6lkrehi 4468 17 30.5 30.5 CD cord-335975-m6lkrehi 4468 18 % % NN cord-335975-m6lkrehi 4468 19 ) ) -RRB- cord-335975-m6lkrehi 4468 20 had have VBD cord-335975-m6lkrehi 4468 21 a a DT cord-335975-m6lkrehi 4468 22 depression depression NN cord-335975-m6lkrehi 4468 23 score score NN cord-335975-m6lkrehi 4468 24 > > XX cord-335975-m6lkrehi 4468 25 11 11 CD cord-335975-m6lkrehi 4468 26 . . . cord-335975-m6lkrehi 4469 1 These these DT cord-335975-m6lkrehi 4469 2 results result NNS cord-335975-m6lkrehi 4469 3 underline underline VBP cord-335975-m6lkrehi 4469 4 the the DT cord-335975-m6lkrehi 4469 5 need need NN cord-335975-m6lkrehi 4469 6 of of IN cord-335975-m6lkrehi 4469 7 psychological psychological JJ cord-335975-m6lkrehi 4469 8 support support NN cord-335975-m6lkrehi 4469 9 after after IN cord-335975-m6lkrehi 4469 10 the the DT cord-335975-m6lkrehi 4469 11 stay stay NN cord-335975-m6lkrehi 4469 12 . . . cord-335975-m6lkrehi 4470 1 Conclusion conclusion NN cord-335975-m6lkrehi 4470 2 : : : cord-335975-m6lkrehi 4471 1 Many many JJ cord-335975-m6lkrehi 4471 2 survivors survivor NNS cord-335975-m6lkrehi 4471 3 of of IN cord-335975-m6lkrehi 4471 4 intensive intensive JJ cord-335975-m6lkrehi 4471 5 care care NN cord-335975-m6lkrehi 4471 6 unit unit NN cord-335975-m6lkrehi 4471 7 reported report VBD cord-335975-m6lkrehi 4471 8 a a DT cord-335975-m6lkrehi 4471 9 high high JJ cord-335975-m6lkrehi 4471 10 level level NN cord-335975-m6lkrehi 4471 11 of of IN cord-335975-m6lkrehi 4471 12 psychological psychological JJ cord-335975-m6lkrehi 4471 13 distress distress NN cord-335975-m6lkrehi 4471 14 . . . cord-335975-m6lkrehi 4472 1 It -PRON- PRP cord-335975-m6lkrehi 4472 2 seems seem VBZ cord-335975-m6lkrehi 4472 3 important important JJ cord-335975-m6lkrehi 4472 4 offer offer NN cord-335975-m6lkrehi 4472 5 at at IN cord-335975-m6lkrehi 4472 6 this this DT cord-335975-m6lkrehi 4472 7 patient patient NN cord-335975-m6lkrehi 4472 8 a a DT cord-335975-m6lkrehi 4472 9 psychological psychological JJ cord-335975-m6lkrehi 4472 10 support support NN cord-335975-m6lkrehi 4472 11 after after IN cord-335975-m6lkrehi 4472 12 an an DT cord-335975-m6lkrehi 4472 13 intensive intensive JJ cord-335975-m6lkrehi 4472 14 care care NN cord-335975-m6lkrehi 4472 15 unit unit NN cord-335975-m6lkrehi 4472 16 stay stay VB cord-335975-m6lkrehi 4472 17 . . . cord-335975-m6lkrehi 4473 1 Most Most JJS cord-335975-m6lkrehi 4473 2 patients patient NNS cord-335975-m6lkrehi 4473 3 needs need VBZ cord-335975-m6lkrehi 4473 4 return return VBP cord-335975-m6lkrehi 4473 5 in in IN cord-335975-m6lkrehi 4473 6 intensive intensive JJ cord-335975-m6lkrehi 4473 7 care care NN cord-335975-m6lkrehi 4473 8 unit unit NN cord-335975-m6lkrehi 4473 9 to to TO cord-335975-m6lkrehi 4473 10 understand understand VB cord-335975-m6lkrehi 4473 11 some some DT cord-335975-m6lkrehi 4473 12 elements element NNS cord-335975-m6lkrehi 4473 13 of of IN cord-335975-m6lkrehi 4473 14 hospitalization hospitalization NN cord-335975-m6lkrehi 4473 15 . . . cord-335975-m6lkrehi 4474 1 Actually actually RB cord-335975-m6lkrehi 4474 2 , , , cord-335975-m6lkrehi 4474 3 this this DT cord-335975-m6lkrehi 4474 4 support support NN cord-335975-m6lkrehi 4474 5 lack lack NN cord-335975-m6lkrehi 4474 6 to to IN cord-335975-m6lkrehi 4474 7 screening screening NN cord-335975-m6lkrehi 4474 8 and and CC cord-335975-m6lkrehi 4474 9 treatment treatment NN cord-335975-m6lkrehi 4474 10 this this DT cord-335975-m6lkrehi 4474 11 psychological psychological JJ cord-335975-m6lkrehi 4474 12 morbidity morbidity NN cord-335975-m6lkrehi 4474 13 . . . cord-335975-m6lkrehi 4475 1 Prevalence prevalence NN cord-335975-m6lkrehi 4475 2 and and CC cord-335975-m6lkrehi 4475 3 description description NN cord-335975-m6lkrehi 4475 4 of of IN cord-335975-m6lkrehi 4475 5 the the DT cord-335975-m6lkrehi 4475 6 complications complication NNS cord-335975-m6lkrehi 4475 7 following follow VBG cord-335975-m6lkrehi 4475 8 a a DT cord-335975-m6lkrehi 4475 9 percutaneous percutaneous JJ cord-335975-m6lkrehi 4475 10 coronary coronary NN cord-335975-m6lkrehi 4475 11 intervention intervention NN cord-335975-m6lkrehi 4475 12 for for IN cord-335975-m6lkrehi 4475 13 a a DT cord-335975-m6lkrehi 4475 14 myocardial myocardial JJ cord-335975-m6lkrehi 4475 15 infarction infarction NN cord-335975-m6lkrehi 4475 16 in in IN cord-335975-m6lkrehi 4475 17 non non JJ cord-335975-m6lkrehi 4475 18 - - JJ cord-335975-m6lkrehi 4475 19 cardiac cardiac JJ cord-335975-m6lkrehi 4475 20 critically critically RB cord-335975-m6lkrehi 4475 21 ill ill JJ cord-335975-m6lkrehi 4475 22 patients patient NNS cord-335975-m6lkrehi 4475 23 : : : cord-335975-m6lkrehi 4475 24 a a DT cord-335975-m6lkrehi 4475 25 retrospective retrospective JJ cord-335975-m6lkrehi 4475 26 single single JJ cord-335975-m6lkrehi 4475 27 - - HYPH cord-335975-m6lkrehi 4475 28 center center NN cord-335975-m6lkrehi 4475 29 Introduction introduction NN cord-335975-m6lkrehi 4475 30 : : : cord-335975-m6lkrehi 4475 31 Type type NN cord-335975-m6lkrehi 4475 32 1 1 CD cord-335975-m6lkrehi 4475 33 myocardial myocardial JJ cord-335975-m6lkrehi 4475 34 infarction infarction NN cord-335975-m6lkrehi 4475 35 ( ( -LRB- cord-335975-m6lkrehi 4475 36 MI MI NNP cord-335975-m6lkrehi 4475 37 ) ) -RRB- cord-335975-m6lkrehi 4475 38 is be VBZ cord-335975-m6lkrehi 4475 39 an an DT cord-335975-m6lkrehi 4475 40 emergency emergency NN cord-335975-m6lkrehi 4475 41 , , . cord-335975-m6lkrehi 4476 1 which which WDT cord-335975-m6lkrehi 4476 2 immediate immediate JJ cord-335975-m6lkrehi 4476 3 invasive invasive JJ cord-335975-m6lkrehi 4476 4 strategy strategy NN cord-335975-m6lkrehi 4476 5 by by IN cord-335975-m6lkrehi 4476 6 a a DT cord-335975-m6lkrehi 4476 7 percutaneous percutaneous JJ cord-335975-m6lkrehi 4476 8 coronary coronary NN cord-335975-m6lkrehi 4476 9 intervention intervention NN cord-335975-m6lkrehi 4476 10 ( ( -LRB- cord-335975-m6lkrehi 4476 11 PCI PCI NNP cord-335975-m6lkrehi 4476 12 ) ) -RRB- cord-335975-m6lkrehi 4476 13 is be VBZ cord-335975-m6lkrehi 4476 14 based base VBN cord-335975-m6lkrehi 4476 15 on on IN cord-335975-m6lkrehi 4476 16 guidelines guideline NNS cord-335975-m6lkrehi 4476 17 for for IN cord-335975-m6lkrehi 4476 18 cardiologic cardiologic JJ cord-335975-m6lkrehi 4476 19 patients patient NNS cord-335975-m6lkrehi 4476 20 . . . cord-335975-m6lkrehi 4477 1 Conversely conversely RB cord-335975-m6lkrehi 4477 2 , , , cord-335975-m6lkrehi 4477 3 the the DT cord-335975-m6lkrehi 4477 4 invasive invasive JJ cord-335975-m6lkrehi 4477 5 strategy strategy NN cord-335975-m6lkrehi 4477 6 remains remain VBZ cord-335975-m6lkrehi 4477 7 uncertain uncertain JJ cord-335975-m6lkrehi 4477 8 for for IN cord-335975-m6lkrehi 4477 9 patients patient NNS cord-335975-m6lkrehi 4477 10 hospitalized hospitalize VBN cord-335975-m6lkrehi 4477 11 in in IN cord-335975-m6lkrehi 4477 12 the the DT cord-335975-m6lkrehi 4477 13 intensive intensive JJ cord-335975-m6lkrehi 4477 14 care care NN cord-335975-m6lkrehi 4477 15 unit unit NN cord-335975-m6lkrehi 4477 16 ( ( -LRB- cord-335975-m6lkrehi 4477 17 ICU ICU NNP cord-335975-m6lkrehi 4477 18 ) ) -RRB- cord-335975-m6lkrehi 4477 19 for for IN cord-335975-m6lkrehi 4477 20 a a DT cord-335975-m6lkrehi 4477 21 primary primary JJ cord-335975-m6lkrehi 4477 22 non non JJ cord-335975-m6lkrehi 4477 23 - - JJ cord-335975-m6lkrehi 4477 24 cardiac cardiac JJ cord-335975-m6lkrehi 4477 25 disease disease NN cord-335975-m6lkrehi 4477 26 with with IN cord-335975-m6lkrehi 4477 27 MI MI NNP cord-335975-m6lkrehi 4477 28 as as IN cord-335975-m6lkrehi 4477 29 a a DT cord-335975-m6lkrehi 4477 30 complication complication NN cord-335975-m6lkrehi 4477 31 , , , cord-335975-m6lkrehi 4477 32 given give VBN cord-335975-m6lkrehi 4477 33 the the DT cord-335975-m6lkrehi 4477 34 ischemic ischemic JJ cord-335975-m6lkrehi 4477 35 and and CC cord-335975-m6lkrehi 4477 36 hemorrhagic hemorrhagic JJ cord-335975-m6lkrehi 4477 37 risks risk NNS cord-335975-m6lkrehi 4477 38 . . . cord-335975-m6lkrehi 4478 1 We -PRON- PRP cord-335975-m6lkrehi 4478 2 aimed aim VBD cord-335975-m6lkrehi 4478 3 to to TO cord-335975-m6lkrehi 4478 4 assess assess VB cord-335975-m6lkrehi 4478 5 the the DT cord-335975-m6lkrehi 4478 6 prevalence prevalence NN cord-335975-m6lkrehi 4478 7 of of IN cord-335975-m6lkrehi 4478 8 - - : cord-335975-m6lkrehi 4478 9 and and CC cord-335975-m6lkrehi 4478 10 describe describe VB cord-335975-m6lkrehi 4478 11 the the DT cord-335975-m6lkrehi 4478 12 major major JJ cord-335975-m6lkrehi 4478 13 adverse adverse JJ cord-335975-m6lkrehi 4478 14 cardiac cardiac JJ cord-335975-m6lkrehi 4478 15 and and CC cord-335975-m6lkrehi 4478 16 hemorrhagic hemorrhagic JJ cord-335975-m6lkrehi 4478 17 events event NNS cord-335975-m6lkrehi 4478 18 occurring occur VBG cord-335975-m6lkrehi 4478 19 in in IN cord-335975-m6lkrehi 4478 20 the the DT cord-335975-m6lkrehi 4478 21 ICU ICU NNP cord-335975-m6lkrehi 4478 22 after after IN cord-335975-m6lkrehi 4478 23 an an DT cord-335975-m6lkrehi 4478 24 invasive invasive JJ cord-335975-m6lkrehi 4478 25 strategy strategy NN cord-335975-m6lkrehi 4478 26 by by IN cord-335975-m6lkrehi 4478 27 PCI PCI NNP cord-335975-m6lkrehi 4478 28 in in IN cord-335975-m6lkrehi 4478 29 this this DT cord-335975-m6lkrehi 4478 30 context context NN cord-335975-m6lkrehi 4478 31 . . . cord-335975-m6lkrehi 4479 1 We -PRON- PRP cord-335975-m6lkrehi 4479 2 conducted conduct VBD cord-335975-m6lkrehi 4479 3 a a DT cord-335975-m6lkrehi 4479 4 retrospective retrospective JJ cord-335975-m6lkrehi 4479 5 single single JJ cord-335975-m6lkrehi 4479 6 - - HYPH cord-335975-m6lkrehi 4479 7 center center NN cord-335975-m6lkrehi 4479 8 5-year 5-year CD cord-335975-m6lkrehi 4479 9 ( ( -LRB- cord-335975-m6lkrehi 4479 10 2012 2012 CD cord-335975-m6lkrehi 4479 11 - - SYM cord-335975-m6lkrehi 4479 12 2017 2017 CD cord-335975-m6lkrehi 4479 13 ) ) -RRB- cord-335975-m6lkrehi 4479 14 study study NN cord-335975-m6lkrehi 4479 15 . . . cord-335975-m6lkrehi 4480 1 All all PDT cord-335975-m6lkrehi 4480 2 the the DT cord-335975-m6lkrehi 4480 3 consecutive consecutive JJ cord-335975-m6lkrehi 4480 4 ICU ICU NNP cord-335975-m6lkrehi 4480 5 patients patient NNS cord-335975-m6lkrehi 4480 6 with with IN cord-335975-m6lkrehi 4480 7 a a DT cord-335975-m6lkrehi 4480 8 suspected suspect VBN cord-335975-m6lkrehi 4480 9 MI MI NNP cord-335975-m6lkrehi 4480 10 undergoing undergo VBG cord-335975-m6lkrehi 4480 11 a a DT cord-335975-m6lkrehi 4480 12 coronarography coronarography NN cord-335975-m6lkrehi 4480 13 were be VBD cord-335975-m6lkrehi 4480 14 screened screen VBN cord-335975-m6lkrehi 4480 15 . . . cord-335975-m6lkrehi 4481 1 Patients patient NNS cord-335975-m6lkrehi 4481 2 treated treat VBN cord-335975-m6lkrehi 4481 3 with with IN cord-335975-m6lkrehi 4481 4 an an DT cord-335975-m6lkrehi 4481 5 invasive invasive JJ cord-335975-m6lkrehi 4481 6 strategy strategy NN cord-335975-m6lkrehi 4481 7 ( ( -LRB- cord-335975-m6lkrehi 4481 8 PCI PCI NNP cord-335975-m6lkrehi 4481 9 performed perform VBN cord-335975-m6lkrehi 4481 10 within within IN cord-335975-m6lkrehi 4481 11 7 7 CD cord-335975-m6lkrehi 4481 12 days day NNS cord-335975-m6lkrehi 4481 13 of of IN cord-335975-m6lkrehi 4481 14 MI MI NNP cord-335975-m6lkrehi 4481 15 ) ) -RRB- cord-335975-m6lkrehi 4481 16 were be VBD cord-335975-m6lkrehi 4481 17 included include VBN cord-335975-m6lkrehi 4481 18 . . . cord-335975-m6lkrehi 4482 1 Patients patient NNS cord-335975-m6lkrehi 4482 2 hospitalized hospitalize VBN cord-335975-m6lkrehi 4482 3 in in IN cord-335975-m6lkrehi 4482 4 ICU ICU NNP cord-335975-m6lkrehi 4482 5 for for IN cord-335975-m6lkrehi 4482 6 cardiac cardiac JJ cord-335975-m6lkrehi 4482 7 disease disease NN cord-335975-m6lkrehi 4482 8 were be VBD cord-335975-m6lkrehi 4482 9 excluded exclude VBN cord-335975-m6lkrehi 4482 10 . . . cord-335975-m6lkrehi 4483 1 The the DT cord-335975-m6lkrehi 4483 2 major major JJ cord-335975-m6lkrehi 4483 3 adverse adverse JJ cord-335975-m6lkrehi 4483 4 cardiac cardiac JJ cord-335975-m6lkrehi 4483 5 events event NNS cord-335975-m6lkrehi 4483 6 ( ( -LRB- cord-335975-m6lkrehi 4483 7 MACE MACE NNP cord-335975-m6lkrehi 4483 8 ) ) -RRB- cord-335975-m6lkrehi 4483 9 were be VBD cord-335975-m6lkrehi 4483 10 defined define VBN cord-335975-m6lkrehi 4483 11 as as IN cord-335975-m6lkrehi 4483 12 post post JJ cord-335975-m6lkrehi 4483 13 - - JJ cord-335975-m6lkrehi 4483 14 procedure procedure JJ cord-335975-m6lkrehi 4483 15 events event NNS cord-335975-m6lkrehi 4483 16 occurring occur VBG cord-335975-m6lkrehi 4483 17 in in IN cord-335975-m6lkrehi 4483 18 the the DT cord-335975-m6lkrehi 4483 19 ICU ICU NNP cord-335975-m6lkrehi 4483 20 , , , cord-335975-m6lkrehi 4483 21 including include VBG cord-335975-m6lkrehi 4483 22 death death NN cord-335975-m6lkrehi 4483 23 from from IN cord-335975-m6lkrehi 4483 24 cardiovascular cardiovascular JJ cord-335975-m6lkrehi 4483 25 causes cause NNS cord-335975-m6lkrehi 4483 26 , , , cord-335975-m6lkrehi 4483 27 MI MI NNP cord-335975-m6lkrehi 4483 28 recurrence recurrence NN cord-335975-m6lkrehi 4483 29 , , , cord-335975-m6lkrehi 4483 30 need need VBP cord-335975-m6lkrehi 4483 31 for for IN cord-335975-m6lkrehi 4483 32 emergent emergent JJ cord-335975-m6lkrehi 4483 33 revascularization revascularization NN cord-335975-m6lkrehi 4483 34 and and CC cord-335975-m6lkrehi 4483 35 stroke stroke NN cord-335975-m6lkrehi 4483 36 . . . cord-335975-m6lkrehi 4484 1 The the DT cord-335975-m6lkrehi 4484 2 major major JJ cord-335975-m6lkrehi 4484 3 adverse adverse JJ cord-335975-m6lkrehi 4484 4 hemorrhagic hemorrhagic JJ cord-335975-m6lkrehi 4484 5 events event NNS cord-335975-m6lkrehi 4484 6 ( ( -LRB- cord-335975-m6lkrehi 4484 7 MAHE MAHE NNP cord-335975-m6lkrehi 4484 8 ) ) -RRB- cord-335975-m6lkrehi 4484 9 were be VBD cord-335975-m6lkrehi 4484 10 defined define VBN cord-335975-m6lkrehi 4484 11 as as IN cord-335975-m6lkrehi 4484 12 post post JJ cord-335975-m6lkrehi 4484 13 - - JJ cord-335975-m6lkrehi 4484 14 procedure procedure JJ cord-335975-m6lkrehi 4484 15 events event NNS cord-335975-m6lkrehi 4484 16 occurring occur VBG cord-335975-m6lkrehi 4484 17 in in IN cord-335975-m6lkrehi 4484 18 the the DT cord-335975-m6lkrehi 4484 19 ICU ICU NNP cord-335975-m6lkrehi 4484 20 , , , cord-335975-m6lkrehi 4484 21 according accord VBG cord-335975-m6lkrehi 4484 22 to to IN cord-335975-m6lkrehi 4484 23 the the DT cord-335975-m6lkrehi 4484 24 Bleeding Bleeding NNP cord-335975-m6lkrehi 4484 25 Academic Academic NNP cord-335975-m6lkrehi 4484 26 Research Research NNP cord-335975-m6lkrehi 4484 27 Consortium Consortium NNP cord-335975-m6lkrehi 4484 28 . . . cord-335975-m6lkrehi 4485 1 Results result NNS cord-335975-m6lkrehi 4485 2 : : : cord-335975-m6lkrehi 4486 1 60 60 CD cord-335975-m6lkrehi 4486 2 ICU ICU NNP cord-335975-m6lkrehi 4486 3 patients patient NNS cord-335975-m6lkrehi 4486 4 suspected suspect VBN cord-335975-m6lkrehi 4486 5 of of IN cord-335975-m6lkrehi 4486 6 MI MI NNP cord-335975-m6lkrehi 4486 7 underwent undergo VBD cord-335975-m6lkrehi 4486 8 a a DT cord-335975-m6lkrehi 4486 9 coronarography coronarography NN cord-335975-m6lkrehi 4486 10 . . . cord-335975-m6lkrehi 4487 1 29 29 CD cord-335975-m6lkrehi 4487 2 patients patient NNS cord-335975-m6lkrehi 4487 3 ( ( -LRB- cord-335975-m6lkrehi 4487 4 48 48 CD cord-335975-m6lkrehi 4487 5 % % NN cord-335975-m6lkrehi 4487 6 ) ) -RRB- cord-335975-m6lkrehi 4487 7 had have VBD cord-335975-m6lkrehi 4487 8 significant significant JJ cord-335975-m6lkrehi 4487 9 coronary coronary JJ cord-335975-m6lkrehi 4487 10 lesions lesion NNS cord-335975-m6lkrehi 4487 11 . . . cord-335975-m6lkrehi 4488 1 Twelve twelve CD cord-335975-m6lkrehi 4488 2 patients patient NNS cord-335975-m6lkrehi 4488 3 were be VBD cord-335975-m6lkrehi 4488 4 excluded exclude VBN cord-335975-m6lkrehi 4488 5 - - HYPH cord-335975-m6lkrehi 4488 6 tri tri JJ cord-335975-m6lkrehi 4488 7 - - JJ cord-335975-m6lkrehi 4488 8 truncular truncular JJ cord-335975-m6lkrehi 4488 9 coronary coronary JJ cord-335975-m6lkrehi 4488 10 involvement involvement NN cord-335975-m6lkrehi 4488 11 ( ( -LRB- cord-335975-m6lkrehi 4488 12 n n NN cord-335975-m6lkrehi 4488 13 = = SYM cord-335975-m6lkrehi 4488 14 12 12 CD cord-335975-m6lkrehi 4488 15 ) ) -RRB- cord-335975-m6lkrehi 4488 16 , , , cord-335975-m6lkrehi 4488 17 delayed delay VBN cord-335975-m6lkrehi 4488 18 procedure procedure NN cord-335975-m6lkrehi 4488 19 ( ( -LRB- cord-335975-m6lkrehi 4488 20 n n NN cord-335975-m6lkrehi 4488 21 = = SYM cord-335975-m6lkrehi 4488 22 4 4 CD cord-335975-m6lkrehi 4488 23 ) ) -RRB- cord-335975-m6lkrehi 4488 24 , , , cord-335975-m6lkrehi 4488 25 cardiogenic cardiogenic JJ cord-335975-m6lkrehi 4488 26 shock shock NN cord-335975-m6lkrehi 4488 27 ( ( -LRB- cord-335975-m6lkrehi 4488 28 n n NN cord-335975-m6lkrehi 4488 29 = = SYM cord-335975-m6lkrehi 4488 30 1 1 CD cord-335975-m6lkrehi 4488 31 ) ) -RRB- cord-335975-m6lkrehi 4488 32 . . . cord-335975-m6lkrehi 4489 1 17 17 CD cord-335975-m6lkrehi 4489 2 patients patient NNS cord-335975-m6lkrehi 4489 3 were be VBD cord-335975-m6lkrehi 4489 4 included include VBN cord-335975-m6lkrehi 4489 5 ( ( -LRB- cord-335975-m6lkrehi 4489 6 11 11 CD cord-335975-m6lkrehi 4489 7 men man NNS cord-335975-m6lkrehi 4489 8 , , , cord-335975-m6lkrehi 4489 9 70 70 CD cord-335975-m6lkrehi 4489 10 years year NNS cord-335975-m6lkrehi 4489 11 [ [ -LRB- cord-335975-m6lkrehi 4489 12 IQR IQR NNP cord-335975-m6lkrehi 4489 13 25 25 CD cord-335975-m6lkrehi 4489 14 - - HYPH cord-335975-m6lkrehi 4489 15 75 75 CD cord-335975-m6lkrehi 4489 16 - - HYPH cord-335975-m6lkrehi 4489 17 68 68 CD cord-335975-m6lkrehi 4489 18 - - SYM cord-335975-m6lkrehi 4489 19 77 77 CD cord-335975-m6lkrehi 4489 20 ] ] -RRB- cord-335975-m6lkrehi 4489 21 , , , cord-335975-m6lkrehi 4489 22 9 9 CD cord-335975-m6lkrehi 4489 23 patients patient NNS cord-335975-m6lkrehi 4489 24 mechanically mechanically RB cord-335975-m6lkrehi 4489 25 ventilated ventilate VBN cord-335975-m6lkrehi 4489 26 , , , cord-335975-m6lkrehi 4489 27 9 9 CD cord-335975-m6lkrehi 4489 28 patients patient NNS cord-335975-m6lkrehi 4489 29 with with IN cord-335975-m6lkrehi 4489 30 sepsis sepsis NN cord-335975-m6lkrehi 4489 31 septic septic JJ cord-335975-m6lkrehi 4489 32 shock shock NN cord-335975-m6lkrehi 4489 33 , , , cord-335975-m6lkrehi 4489 34 median median JJ cord-335975-m6lkrehi 4489 35 SOFA sofa NN cord-335975-m6lkrehi 4489 36 Score Score NNP cord-335975-m6lkrehi 4489 37 at at IN cord-335975-m6lkrehi 4489 38 the the DT cord-335975-m6lkrehi 4489 39 time time NN cord-335975-m6lkrehi 4489 40 of of IN cord-335975-m6lkrehi 4489 41 MI MI NNP cord-335975-m6lkrehi 4489 42 8 8 CD cord-335975-m6lkrehi 4489 43 [ [ -LRB- cord-335975-m6lkrehi 4489 44 3 3 CD cord-335975-m6lkrehi 4489 45 ] ] -RRB- cord-335975-m6lkrehi 4489 46 [ [ -LRB- cord-335975-m6lkrehi 4489 47 4 4 CD cord-335975-m6lkrehi 4489 48 ] ] -RRB- cord-335975-m6lkrehi 4489 49 [ [ -LRB- cord-335975-m6lkrehi 4489 50 5 5 CD cord-335975-m6lkrehi 4489 51 ] ] -RRB- cord-335975-m6lkrehi 4489 52 [ [ -LRB- cord-335975-m6lkrehi 4489 53 6 6 CD cord-335975-m6lkrehi 4489 54 ] ] -RRB- cord-335975-m6lkrehi 4489 55 [ [ -LRB- cord-335975-m6lkrehi 4489 56 7 7 CD cord-335975-m6lkrehi 4489 57 ] ] -RRB- cord-335975-m6lkrehi 4489 58 [ [ -LRB- cord-335975-m6lkrehi 4489 59 8 8 CD cord-335975-m6lkrehi 4489 60 ] ] -RRB- cord-335975-m6lkrehi 4489 61 [ [ -LRB- cord-335975-m6lkrehi 4489 62 9 9 CD cord-335975-m6lkrehi 4489 63 ] ] -RRB- cord-335975-m6lkrehi 4489 64 [ [ -LRB- cord-335975-m6lkrehi 4489 65 10 10 CD cord-335975-m6lkrehi 4489 66 ] ] -RRB- cord-335975-m6lkrehi 4489 67 ) ) -RRB- cord-335975-m6lkrehi 4489 68 . . . cord-335975-m6lkrehi 4490 1 A a DT cord-335975-m6lkrehi 4490 2 PCI pci NN cord-335975-m6lkrehi 4490 3 was be VBD cord-335975-m6lkrehi 4490 4 performed perform VBN cord-335975-m6lkrehi 4490 5 during during IN cord-335975-m6lkrehi 4490 6 the the DT cord-335975-m6lkrehi 4490 7 first first JJ cord-335975-m6lkrehi 4490 8 day day NN cord-335975-m6lkrehi 4490 9 after after IN cord-335975-m6lkrehi 4490 10 diagnosis diagnosis NN cord-335975-m6lkrehi 4490 11 of of IN cord-335975-m6lkrehi 4490 12 MI MI NNP cord-335975-m6lkrehi 4490 13 in in IN cord-335975-m6lkrehi 4490 14 9 9 CD cord-335975-m6lkrehi 4490 15 patients patient NNS cord-335975-m6lkrehi 4490 16 ( ( -LRB- cord-335975-m6lkrehi 4490 17 53 53 CD cord-335975-m6lkrehi 4490 18 % % NN cord-335975-m6lkrehi 4490 19 ) ) -RRB- cord-335975-m6lkrehi 4490 20 ( ( -LRB- cord-335975-m6lkrehi 4490 21 median median NN cord-335975-m6lkrehi 4490 22 time-0 time-0 NNP cord-335975-m6lkrehi 4490 23 day day NN cord-335975-m6lkrehi 4491 1 [ [ -LRB- cord-335975-m6lkrehi 4491 2 IQR IQR NNP cord-335975-m6lkrehi 4491 3 25 25 CD cord-335975-m6lkrehi 4491 4 - - HYPH cord-335975-m6lkrehi 4491 5 75 75 CD cord-335975-m6lkrehi 4491 6 - - HYPH cord-335975-m6lkrehi 4491 7 0 0 CD cord-335975-m6lkrehi 4491 8 - - HYPH cord-335975-m6lkrehi 4491 9 2 2 CD cord-335975-m6lkrehi 4491 10 ] ] -RRB- cord-335975-m6lkrehi 4491 11 ) ) -RRB- cord-335975-m6lkrehi 4491 12 . . . cord-335975-m6lkrehi 4492 1 A a DT cord-335975-m6lkrehi 4492 2 MACE mace NN cord-335975-m6lkrehi 4492 3 occurred occur VBD cord-335975-m6lkrehi 4492 4 in in IN cord-335975-m6lkrehi 4492 5 3 3 CD cord-335975-m6lkrehi 4492 6 patients patient NNS cord-335975-m6lkrehi 4492 7 ( ( -LRB- cord-335975-m6lkrehi 4492 8 18 18 CD cord-335975-m6lkrehi 4492 9 % % NN cord-335975-m6lkrehi 4492 10 ) ) -RRB- cord-335975-m6lkrehi 4492 11 , , , cord-335975-m6lkrehi 4492 12 including include VBG cord-335975-m6lkrehi 4492 13 stroke stroke NN cord-335975-m6lkrehi 4492 14 ( ( -LRB- cord-335975-m6lkrehi 4492 15 n n NN cord-335975-m6lkrehi 4492 16 = = SYM cord-335975-m6lkrehi 4492 17 2 2 CD cord-335975-m6lkrehi 4492 18 ) ) -RRB- cord-335975-m6lkrehi 4492 19 and and CC cord-335975-m6lkrehi 4492 20 MI MI NNP cord-335975-m6lkrehi 4492 21 recurrence recurrence NN cord-335975-m6lkrehi 4492 22 without without IN cord-335975-m6lkrehi 4492 23 revascularization revascularization NN cord-335975-m6lkrehi 4492 24 ( ( -LRB- cord-335975-m6lkrehi 4492 25 n n NN cord-335975-m6lkrehi 4492 26 = = SYM cord-335975-m6lkrehi 4492 27 1 1 CD cord-335975-m6lkrehi 4492 28 ) ) -RRB- cord-335975-m6lkrehi 4492 29 . . . cord-335975-m6lkrehi 4493 1 No no DT cord-335975-m6lkrehi 4493 2 patients patient NNS cord-335975-m6lkrehi 4493 3 deceased decease VBN cord-335975-m6lkrehi 4493 4 from from IN cord-335975-m6lkrehi 4493 5 cardiovascular cardiovascular JJ cord-335975-m6lkrehi 4493 6 causes cause NNS cord-335975-m6lkrehi 4493 7 in in IN cord-335975-m6lkrehi 4493 8 the the DT cord-335975-m6lkrehi 4493 9 ICU ICU NNP cord-335975-m6lkrehi 4493 10 , , , cord-335975-m6lkrehi 4493 11 neither neither CC cord-335975-m6lkrehi 4493 12 at at IN cord-335975-m6lkrehi 4493 13 6 6 CD cord-335975-m6lkrehi 4493 14 months month NNS cord-335975-m6lkrehi 4493 15 post post NN cord-335975-m6lkrehi 4493 16 - - NN cord-335975-m6lkrehi 4493 17 procedure procedure JJ cord-335975-m6lkrehi 4493 18 ( ( -LRB- cord-335975-m6lkrehi 4493 19 Table table NN cord-335975-m6lkrehi 4493 20 1 1 CD cord-335975-m6lkrehi 4493 21 ) ) -RRB- cord-335975-m6lkrehi 4493 22 . . . cord-335975-m6lkrehi 4494 1 A a DT cord-335975-m6lkrehi 4494 2 MAHE MAHE NNP cord-335975-m6lkrehi 4494 3 occurred occur VBD cord-335975-m6lkrehi 4494 4 in in IN cord-335975-m6lkrehi 4494 5 3 3 CD cord-335975-m6lkrehi 4494 6 patients patient NNS cord-335975-m6lkrehi 4494 7 ( ( -LRB- cord-335975-m6lkrehi 4494 8 18 18 CD cord-335975-m6lkrehi 4494 9 % % NN cord-335975-m6lkrehi 4494 10 ) ) -RRB- cord-335975-m6lkrehi 4494 11 , , , cord-335975-m6lkrehi 4494 12 2 2 CD cord-335975-m6lkrehi 4494 13 of of IN cord-335975-m6lkrehi 4494 14 whom whom WP cord-335975-m6lkrehi 4494 15 had have VBD cord-335975-m6lkrehi 4494 16 a a DT cord-335975-m6lkrehi 4494 17 MACE mace NN cord-335975-m6lkrehi 4494 18 . . . cord-335975-m6lkrehi 4495 1 Altogether altogether RB cord-335975-m6lkrehi 4495 2 , , , cord-335975-m6lkrehi 4495 3 the the DT cord-335975-m6lkrehi 4495 4 prevalence prevalence NN cord-335975-m6lkrehi 4495 5 of of IN cord-335975-m6lkrehi 4495 6 major major JJ cord-335975-m6lkrehi 4495 7 adverse adverse JJ cord-335975-m6lkrehi 4495 8 cardiovascular cardiovascular JJ cord-335975-m6lkrehi 4495 9 events event NNS cord-335975-m6lkrehi 4495 10 combining combine VBG cord-335975-m6lkrehi 4495 11 MACE MACE NNP cord-335975-m6lkrehi 4495 12 and and CC cord-335975-m6lkrehi 4495 13 MAHE MAHE NNP cord-335975-m6lkrehi 4495 14 was be VBD cord-335975-m6lkrehi 4495 15 0.24 0.24 CD cord-335975-m6lkrehi 4496 1 ( ( -LRB- cord-335975-m6lkrehi 4496 2 95 95 CD cord-335975-m6lkrehi 4496 3 % % NN cord-335975-m6lkrehi 4496 4 CI CI NNP cord-335975-m6lkrehi 4496 5 0.01 0.01 CD cord-335975-m6lkrehi 4496 6 - - HYPH cord-335975-m6lkrehi 4496 7 0.46 0.46 CD cord-335975-m6lkrehi 4496 8 ) ) -RRB- cord-335975-m6lkrehi 4496 9 . . . cord-335975-m6lkrehi 4497 1 There there EX cord-335975-m6lkrehi 4497 2 was be VBD cord-335975-m6lkrehi 4497 3 no no DT cord-335975-m6lkrehi 4497 4 difference difference NN cord-335975-m6lkrehi 4497 5 between between IN cord-335975-m6lkrehi 4497 6 septic septic JJ cord-335975-m6lkrehi 4497 7 and and CC cord-335975-m6lkrehi 4497 8 non non JJ cord-335975-m6lkrehi 4497 9 septic septic JJ cord-335975-m6lkrehi 4497 10 patients patient NNS cord-335975-m6lkrehi 4497 11 regarding regard VBG cord-335975-m6lkrehi 4497 12 the the DT cord-335975-m6lkrehi 4497 13 prevalence prevalence NN cord-335975-m6lkrehi 4497 14 of of IN cord-335975-m6lkrehi 4497 15 MACE MACE NNP cord-335975-m6lkrehi 4497 16 or or CC cord-335975-m6lkrehi 4497 17 MAHE MAHE NNP cord-335975-m6lkrehi 4497 18 . . . cord-335975-m6lkrehi 4498 1 The the DT cord-335975-m6lkrehi 4498 2 prevalence prevalence NN cord-335975-m6lkrehi 4498 3 of of IN cord-335975-m6lkrehi 4498 4 adverse adverse JJ cord-335975-m6lkrehi 4498 5 cardiovascular cardiovascular JJ cord-335975-m6lkrehi 4498 6 events event NNS cord-335975-m6lkrehi 4498 7 after after IN cord-335975-m6lkrehi 4498 8 an an DT cord-335975-m6lkrehi 4498 9 invasive invasive JJ cord-335975-m6lkrehi 4498 10 strategy strategy NN cord-335975-m6lkrehi 4498 11 by by IN cord-335975-m6lkrehi 4498 12 PCI PCI NNP cord-335975-m6lkrehi 4498 13 is be VBZ cord-335975-m6lkrehi 4498 14 high high JJ cord-335975-m6lkrehi 4498 15 in in IN cord-335975-m6lkrehi 4498 16 non non JJ cord-335975-m6lkrehi 4498 17 - - JJ cord-335975-m6lkrehi 4498 18 cardiac cardiac JJ cord-335975-m6lkrehi 4498 19 critically critically RB cord-335975-m6lkrehi 4498 20 ill ill JJ cord-335975-m6lkrehi 4498 21 patients patient NNS cord-335975-m6lkrehi 4498 22 with with IN cord-335975-m6lkrehi 4498 23 MI MI NNP cord-335975-m6lkrehi 4498 24 . . . cord-335975-m6lkrehi 4499 1 Larger large JJR cord-335975-m6lkrehi 4499 2 studies study NNS cord-335975-m6lkrehi 4499 3 are be VBP cord-335975-m6lkrehi 4499 4 needed need VBN cord-335975-m6lkrehi 4499 5 to to TO cord-335975-m6lkrehi 4499 6 determine determine VB cord-335975-m6lkrehi 4499 7 which which WDT cord-335975-m6lkrehi 4499 8 patients patient NNS cord-335975-m6lkrehi 4499 9 may may MD cord-335975-m6lkrehi 4499 10 benefit benefit VB cord-335975-m6lkrehi 4499 11 from from IN cord-335975-m6lkrehi 4499 12 this this DT cord-335975-m6lkrehi 4499 13 procedure procedure NN cord-335975-m6lkrehi 4499 14 . . . cord-335975-m6lkrehi 4500 1 Introduction introduction NN cord-335975-m6lkrehi 4500 2 : : : cord-335975-m6lkrehi 4501 1 Resuscitated resuscitate VBN cord-335975-m6lkrehi 4501 2 cardiac cardiac JJ cord-335975-m6lkrehi 4501 3 arrest arrest NN cord-335975-m6lkrehi 4501 4 ( ( -LRB- cord-335975-m6lkrehi 4501 5 CA CA NNP cord-335975-m6lkrehi 4501 6 ) ) -RRB- cord-335975-m6lkrehi 4501 7 lead lead VB cord-335975-m6lkrehi 4501 8 to to IN cord-335975-m6lkrehi 4501 9 immune immune JJ cord-335975-m6lkrehi 4501 10 alteration alteration NN cord-335975-m6lkrehi 4501 11 including include VBG cord-335975-m6lkrehi 4501 12 lymphopenia lymphopenia NNP cord-335975-m6lkrehi 4501 13 , , , cord-335975-m6lkrehi 4501 14 decreased decrease VBD cord-335975-m6lkrehi 4501 15 monocyte monocyte NNP cord-335975-m6lkrehi 4501 16 HLA HLA NNP cord-335975-m6lkrehi 4501 17 - - HYPH cord-335975-m6lkrehi 4501 18 DR DR NNP cord-335975-m6lkrehi 4501 19 ( ( -LRB- cord-335975-m6lkrehi 4501 20 mHLA mHLA NNP cord-335975-m6lkrehi 4501 21 - - NNP cord-335975-m6lkrehi 4501 22 DR DR NNP cord-335975-m6lkrehi 4501 23 ) ) -RRB- cord-335975-m6lkrehi 4501 24 expression expression NN cord-335975-m6lkrehi 4501 25 and and CC cord-335975-m6lkrehi 4501 26 dysregulated dysregulated JJ cord-335975-m6lkrehi 4501 27 production production NN cord-335975-m6lkrehi 4501 28 of of IN cord-335975-m6lkrehi 4501 29 cytokines cytokine NNS cord-335975-m6lkrehi 4501 30 . . . cord-335975-m6lkrehi 4502 1 In in IN cord-335975-m6lkrehi 4502 2 a a DT cord-335975-m6lkrehi 4502 3 recent recent JJ cord-335975-m6lkrehi 4502 4 multicenter multicenter NN cord-335975-m6lkrehi 4502 5 randomized randomized JJ cord-335975-m6lkrehi 4502 6 clinical clinical JJ cord-335975-m6lkrehi 4502 7 trial trial NN cord-335975-m6lkrehi 4502 8 , , , cord-335975-m6lkrehi 4502 9 we -PRON- PRP cord-335975-m6lkrehi 4502 10 tested test VBD cord-335975-m6lkrehi 4502 11 the the DT cord-335975-m6lkrehi 4502 12 hypothesis hypothesis NN cord-335975-m6lkrehi 4502 13 that that WDT cord-335975-m6lkrehi 4502 14 Cyclosprine Cyclosprine NNP cord-335975-m6lkrehi 4502 15 A A NNP cord-335975-m6lkrehi 4502 16 ( ( -LRB- cord-335975-m6lkrehi 4502 17 CsA csa NN cord-335975-m6lkrehi 4502 18 ) ) -RRB- cord-335975-m6lkrehi 4502 19 would would MD cord-335975-m6lkrehi 4502 20 limit limit VB cord-335975-m6lkrehi 4502 21 organ organ NN cord-335975-m6lkrehi 4502 22 failures failure NNS cord-335975-m6lkrehi 4502 23 following follow VBG cord-335975-m6lkrehi 4502 24 out out IN cord-335975-m6lkrehi 4502 25 - - HYPH cord-335975-m6lkrehi 4502 26 of of IN cord-335975-m6lkrehi 4502 27 - - HYPH cord-335975-m6lkrehi 4502 28 hospital hospital NN cord-335975-m6lkrehi 4502 29 cardiac cardiac JJ cord-335975-m6lkrehi 4502 30 arrest arrest NN cord-335975-m6lkrehi 4502 31 ( ( -LRB- cord-335975-m6lkrehi 4502 32 OHCA OHCA NNP cord-335975-m6lkrehi 4502 33 ) ) -RRB- cord-335975-m6lkrehi 4502 34 . . . cord-335975-m6lkrehi 4503 1 In in IN cord-335975-m6lkrehi 4503 2 a a DT cord-335975-m6lkrehi 4503 3 substudy substudy NN cord-335975-m6lkrehi 4503 4 , , , cord-335975-m6lkrehi 4503 5 we -PRON- PRP cord-335975-m6lkrehi 4503 6 aimed aim VBD cord-335975-m6lkrehi 4503 7 to to TO cord-335975-m6lkrehi 4503 8 determine determine VB cord-335975-m6lkrehi 4503 9 the the DT cord-335975-m6lkrehi 4503 10 influence influence NN cord-335975-m6lkrehi 4503 11 of of IN cord-335975-m6lkrehi 4503 12 CsA csa NN cord-335975-m6lkrehi 4503 13 on on IN cord-335975-m6lkrehi 4503 14 OHCA OHCA NNP cord-335975-m6lkrehi 4503 15 - - HYPH cord-335975-m6lkrehi 4503 16 induced induce VBN cord-335975-m6lkrehi 4503 17 immune immune JJ cord-335975-m6lkrehi 4503 18 dysfunction dysfunction NN cord-335975-m6lkrehi 4503 19 . . . cord-335975-m6lkrehi 4504 1 This this DT cord-335975-m6lkrehi 4504 2 study study NN cord-335975-m6lkrehi 4504 3 is be VBZ cord-335975-m6lkrehi 4504 4 a a DT cord-335975-m6lkrehi 4504 5 predefined predefined JJ cord-335975-m6lkrehi 4504 6 substudy substudy NN cord-335975-m6lkrehi 4504 7 of of IN cord-335975-m6lkrehi 4504 8 the the DT cord-335975-m6lkrehi 4504 9 randomized randomized JJ cord-335975-m6lkrehi 4504 10 CYRUS CYRUS NNP cord-335975-m6lkrehi 4504 11 trial trial NN cord-335975-m6lkrehi 4504 12 ( ( -LRB- cord-335975-m6lkrehi 4504 13 Cyclosporine cyclosporine NN cord-335975-m6lkrehi 4504 14 in in IN cord-335975-m6lkrehi 4504 15 CA CA NNP cord-335975-m6lkrehi 4504 16 resuscitation resuscitation NN cord-335975-m6lkrehi 4504 17 ) ) -RRB- cord-335975-m6lkrehi 4504 18 . . . cord-335975-m6lkrehi 4505 1 Patients patient NNS cord-335975-m6lkrehi 4505 2 with with IN cord-335975-m6lkrehi 4505 3 non non JJ cord-335975-m6lkrehi 4505 4 - - JJ cord-335975-m6lkrehi 4505 5 shockable shockable JJ cord-335975-m6lkrehi 4505 6 OHCA OHCA NNP cord-335975-m6lkrehi 4505 7 randomly randomly RB cord-335975-m6lkrehi 4505 8 received receive VBD cord-335975-m6lkrehi 4505 9 either either CC cord-335975-m6lkrehi 4505 10 an an DT cord-335975-m6lkrehi 4505 11 intravenous intravenous JJ cord-335975-m6lkrehi 4505 12 bolus bolus NN cord-335975-m6lkrehi 4505 13 injection injection NN cord-335975-m6lkrehi 4505 14 of of IN cord-335975-m6lkrehi 4505 15 CsA CsA NNP cord-335975-m6lkrehi 4505 16 ( ( -LRB- cord-335975-m6lkrehi 4505 17 2.5 2.5 CD cord-335975-m6lkrehi 4505 18 mg mg NNP cord-335975-m6lkrehi 4505 19 kg kg NNP cord-335975-m6lkrehi 4505 20 ) ) -RRB- cord-335975-m6lkrehi 4505 21 at at IN cord-335975-m6lkrehi 4505 22 the the DT cord-335975-m6lkrehi 4505 23 onset onset NN cord-335975-m6lkrehi 4505 24 of of IN cord-335975-m6lkrehi 4505 25 advanced advanced JJ cord-335975-m6lkrehi 4505 26 cardiovascular cardiovascular JJ cord-335975-m6lkrehi 4505 27 life life NN cord-335975-m6lkrehi 4505 28 support support NN cord-335975-m6lkrehi 4505 29 ( ( -LRB- cord-335975-m6lkrehi 4505 30 CsA CsA NNP cord-335975-m6lkrehi 4505 31 group group NN cord-335975-m6lkrehi 4505 32 ) ) -RRB- cord-335975-m6lkrehi 4505 33 or or CC cord-335975-m6lkrehi 4505 34 no no DT cord-335975-m6lkrehi 4505 35 additional additional JJ cord-335975-m6lkrehi 4505 36 intervention intervention NN cord-335975-m6lkrehi 4505 37 ( ( -LRB- cord-335975-m6lkrehi 4505 38 Control Control NNP cord-335975-m6lkrehi 4505 39 group group NN cord-335975-m6lkrehi 4505 40 ) ) -RRB- cord-335975-m6lkrehi 4505 41 . . . cord-335975-m6lkrehi 4506 1 Patients patient NNS cord-335975-m6lkrehi 4506 2 from from IN cord-335975-m6lkrehi 4506 3 the the DT cord-335975-m6lkrehi 4506 4 coordinating coordinate VBG cord-335975-m6lkrehi 4506 5 center center NN cord-335975-m6lkrehi 4506 6 were be VBD cord-335975-m6lkrehi 4506 7 sampled sample VBN cord-335975-m6lkrehi 4506 8 at at IN cord-335975-m6lkrehi 4506 9 admission admission NN cord-335975-m6lkrehi 4506 10 ( ( -LRB- cord-335975-m6lkrehi 4506 11 D0 D0 NNP cord-335975-m6lkrehi 4506 12 ) ) -RRB- cord-335975-m6lkrehi 4506 13 and and CC cord-335975-m6lkrehi 4506 14 at at IN cord-335975-m6lkrehi 4506 15 24 24 CD cord-335975-m6lkrehi 4506 16 h h NN cord-335975-m6lkrehi 4506 17 ( ( -LRB- cord-335975-m6lkrehi 4506 18 D1 D1 NNP cord-335975-m6lkrehi 4506 19 ) ) -RRB- cord-335975-m6lkrehi 4506 20 . . . cord-335975-m6lkrehi 4507 1 Complete complete JJ cord-335975-m6lkrehi 4507 2 blood blood NN cord-335975-m6lkrehi 4507 3 count count NN cord-335975-m6lkrehi 4507 4 , , , cord-335975-m6lkrehi 4507 5 CD4 CD4 NNP cord-335975-m6lkrehi 4507 6 + + CC cord-335975-m6lkrehi 4507 7 lymphocytes lymphocyte NNS cord-335975-m6lkrehi 4507 8 count count VBP cord-335975-m6lkrehi 4507 9 and and CC cord-335975-m6lkrehi 4507 10 mHLA mHLA NNP cord-335975-m6lkrehi 4507 11 - - NNP cord-335975-m6lkrehi 4507 12 DR DR NNP cord-335975-m6lkrehi 4507 13 were be VBD cord-335975-m6lkrehi 4507 14 evaluated evaluate VBN cord-335975-m6lkrehi 4507 15 by by IN cord-335975-m6lkrehi 4507 16 flow flow NN cord-335975-m6lkrehi 4507 17 cytometry cytometry NN cord-335975-m6lkrehi 4507 18 . . . cord-335975-m6lkrehi 4508 1 Serum serum NN cord-335975-m6lkrehi 4508 2 levels level NNS cord-335975-m6lkrehi 4508 3 of of IN cord-335975-m6lkrehi 4508 4 IL-1 IL-1 NNP cord-335975-m6lkrehi 4508 5 , , , cord-335975-m6lkrehi 4508 6 IL-6 IL-6 NNP cord-335975-m6lkrehi 4508 7 , , , cord-335975-m6lkrehi 4508 8 IL-8 IL-8 NNP cord-335975-m6lkrehi 4508 9 , , , cord-335975-m6lkrehi 4508 10 IL-10 IL-10 NNP cord-335975-m6lkrehi 4508 11 and and CC cord-335975-m6lkrehi 4508 12 TNFα TNFα NNP cord-335975-m6lkrehi 4508 13 + + SYM cord-335975-m6lkrehi 4508 14 were be VBD cord-335975-m6lkrehi 4508 15 measured measure VBN cord-335975-m6lkrehi 4508 16 by by IN cord-335975-m6lkrehi 4508 17 ELISA ELISA NNP cord-335975-m6lkrehi 4508 18 test test NN cord-335975-m6lkrehi 4508 19 on on IN cord-335975-m6lkrehi 4508 20 frozen frozen JJ cord-335975-m6lkrehi 4508 21 samples sample NNS cord-335975-m6lkrehi 4508 22 . . . cord-335975-m6lkrehi 4509 1 Results result NNS cord-335975-m6lkrehi 4509 2 : : : cord-335975-m6lkrehi 4510 1 A a DT cord-335975-m6lkrehi 4510 2 total total NN cord-335975-m6lkrehi 4510 3 of of IN cord-335975-m6lkrehi 4510 4 33 33 CD cord-335975-m6lkrehi 4510 5 patients patient NNS cord-335975-m6lkrehi 4510 6 were be VBD cord-335975-m6lkrehi 4510 7 sampled-17 sampled-17 CD cord-335975-m6lkrehi 4510 8 patients patient NNS cord-335975-m6lkrehi 4510 9 from from IN cord-335975-m6lkrehi 4510 10 the the DT cord-335975-m6lkrehi 4510 11 CsA CsA NNP cord-335975-m6lkrehi 4510 12 group group NN cord-335975-m6lkrehi 4510 13 and and CC cord-335975-m6lkrehi 4510 14 16 16 CD cord-335975-m6lkrehi 4510 15 from from IN cord-335975-m6lkrehi 4510 16 the the DT cord-335975-m6lkrehi 4510 17 Control Control NNP cord-335975-m6lkrehi 4510 18 group group NN cord-335975-m6lkrehi 4510 19 . . . cord-335975-m6lkrehi 4511 1 The the DT cord-335975-m6lkrehi 4511 2 characteristics characteristic NNS cord-335975-m6lkrehi 4511 3 of of IN cord-335975-m6lkrehi 4511 4 the the DT cord-335975-m6lkrehi 4511 5 patients patient NNS cord-335975-m6lkrehi 4511 6 , , , cord-335975-m6lkrehi 4511 7 including include VBG cord-335975-m6lkrehi 4511 8 resuscitation resuscitation NN cord-335975-m6lkrehi 4511 9 data datum NNS cord-335975-m6lkrehi 4511 10 , , , cord-335975-m6lkrehi 4511 11 were be VBD cord-335975-m6lkrehi 4511 12 also also RB cord-335975-m6lkrehi 4511 13 similar similar JJ cord-335975-m6lkrehi 4511 14 between between IN cord-335975-m6lkrehi 4511 15 the the DT cord-335975-m6lkrehi 4511 16 two two CD cord-335975-m6lkrehi 4511 17 groups group NNS cord-335975-m6lkrehi 4511 18 at at IN cord-335975-m6lkrehi 4511 19 admission admission NN cord-335975-m6lkrehi 4511 20 . . . cord-335975-m6lkrehi 4512 1 The the DT cord-335975-m6lkrehi 4512 2 severity severity NN cord-335975-m6lkrehi 4512 3 of of IN cord-335975-m6lkrehi 4512 4 organ organ NN cord-335975-m6lkrehi 4512 5 failure failure NN cord-335975-m6lkrehi 4512 6 as as IN cord-335975-m6lkrehi 4512 7 assessed assess VBN cord-335975-m6lkrehi 4512 8 by by IN cord-335975-m6lkrehi 4512 9 the the DT cord-335975-m6lkrehi 4512 10 SOFA sofa NN cord-335975-m6lkrehi 4512 11 score score NN cord-335975-m6lkrehi 4512 12 at at IN cord-335975-m6lkrehi 4512 13 admission admission NN cord-335975-m6lkrehi 4512 14 was be VBD cord-335975-m6lkrehi 4512 15 similar similar JJ cord-335975-m6lkrehi 4512 16 between between IN cord-335975-m6lkrehi 4512 17 groups group NNS cord-335975-m6lkrehi 4512 18 . . . cord-335975-m6lkrehi 4513 1 All all DT cord-335975-m6lkrehi 4513 2 patients patient NNS cord-335975-m6lkrehi 4513 3 Introduction introduction NN cord-335975-m6lkrehi 4513 4 : : : cord-335975-m6lkrehi 4514 1 Critically critically RB cord-335975-m6lkrehi 4514 2 ill ill JJ cord-335975-m6lkrehi 4514 3 patients patient NNS cord-335975-m6lkrehi 4514 4 experience experience VBP cord-335975-m6lkrehi 4514 5 major major JJ cord-335975-m6lkrehi 4514 6 insults insult NNS cord-335975-m6lkrehi 4514 7 that that WDT cord-335975-m6lkrehi 4514 8 lead lead VBP cord-335975-m6lkrehi 4514 9 to to IN cord-335975-m6lkrehi 4514 10 increased increase VBN cord-335975-m6lkrehi 4514 11 protein protein NN cord-335975-m6lkrehi 4514 12 catabolism catabolism NN cord-335975-m6lkrehi 4514 13 and and CC cord-335975-m6lkrehi 4514 14 a a DT cord-335975-m6lkrehi 4514 15 significant significant JJ cord-335975-m6lkrehi 4514 16 loss loss NN cord-335975-m6lkrehi 4514 17 of of IN cord-335975-m6lkrehi 4514 18 lean lean JJ cord-335975-m6lkrehi 4514 19 body body NN cord-335975-m6lkrehi 4514 20 mass mass NN cord-335975-m6lkrehi 4514 21 with with IN cord-335975-m6lkrehi 4514 22 an an DT cord-335975-m6lkrehi 4514 23 impact impact NN cord-335975-m6lkrehi 4514 24 on on IN cord-335975-m6lkrehi 4514 25 weaning wean VBG cord-335975-m6lkrehi 4514 26 from from IN cord-335975-m6lkrehi 4514 27 the the DT cord-335975-m6lkrehi 4514 28 ventilator ventilator NN cord-335975-m6lkrehi 4514 29 and and CC cord-335975-m6lkrehi 4514 30 muscle muscle NN cord-335975-m6lkrehi 4514 31 recovery recovery NN cord-335975-m6lkrehi 4514 32 . . . cord-335975-m6lkrehi 4515 1 In in IN cord-335975-m6lkrehi 4515 2 critically critically RB cord-335975-m6lkrehi 4515 3 ill ill JJ cord-335975-m6lkrehi 4515 4 patients patient NNS cord-335975-m6lkrehi 4515 5 , , , cord-335975-m6lkrehi 4515 6 severe severe JJ cord-335975-m6lkrehi 4515 7 and and CC cord-335975-m6lkrehi 4515 8 persistent persistent JJ cord-335975-m6lkrehi 4515 9 testosterone testosterone NN cord-335975-m6lkrehi 4515 10 deficiency deficiency NN cord-335975-m6lkrehi 4515 11 is be VBZ cord-335975-m6lkrehi 4515 12 very very RB cord-335975-m6lkrehi 4515 13 common common JJ cord-335975-m6lkrehi 4515 14 after after IN cord-335975-m6lkrehi 4515 15 ICU ICU NNP cord-335975-m6lkrehi 4515 16 admission admission NN cord-335975-m6lkrehi 4515 17 . . . cord-335975-m6lkrehi 4516 1 Administration administration NN cord-335975-m6lkrehi 4516 2 of of IN cord-335975-m6lkrehi 4516 3 testosterone testosterone NN cord-335975-m6lkrehi 4516 4 may may MD cord-335975-m6lkrehi 4516 5 induce induce VB cord-335975-m6lkrehi 4516 6 skeletal skeletal JJ cord-335975-m6lkrehi 4516 7 muscle muscle NN cord-335975-m6lkrehi 4516 8 fiber fiber NN cord-335975-m6lkrehi 4516 9 hypertrophy hypertrophy NN cord-335975-m6lkrehi 4516 10 and and CC cord-335975-m6lkrehi 4516 11 decreases decrease VBZ cord-335975-m6lkrehi 4516 12 protein protein NN cord-335975-m6lkrehi 4516 13 breakdown breakdown NN cord-335975-m6lkrehi 4516 14 . . . cord-335975-m6lkrehi 4517 1 The the DT cord-335975-m6lkrehi 4517 2 aim aim NN cord-335975-m6lkrehi 4517 3 of of IN cord-335975-m6lkrehi 4517 4 this this DT cord-335975-m6lkrehi 4517 5 work work NN cord-335975-m6lkrehi 4517 6 is be VBZ cord-335975-m6lkrehi 4517 7 to to TO cord-335975-m6lkrehi 4517 8 assess assess VB cord-335975-m6lkrehi 4517 9 testosterone testosterone NN cord-335975-m6lkrehi 4517 10 levels level NNS cord-335975-m6lkrehi 4517 11 in in IN cord-335975-m6lkrehi 4517 12 critical critical JJ cord-335975-m6lkrehi 4517 13 ill ill JJ cord-335975-m6lkrehi 4517 14 patients patient NNS cord-335975-m6lkrehi 4517 15 and and CC cord-335975-m6lkrehi 4517 16 to to TO cord-335975-m6lkrehi 4517 17 evaluate evaluate VB cord-335975-m6lkrehi 4517 18 the the DT cord-335975-m6lkrehi 4517 19 safety safety NN cord-335975-m6lkrehi 4517 20 of of IN cord-335975-m6lkrehi 4517 21 testosterone testosterone NN cord-335975-m6lkrehi 4517 22 gel gel NN cord-335975-m6lkrehi 4517 23 administration administration NN cord-335975-m6lkrehi 4517 24 . . . cord-335975-m6lkrehi 4518 1 This this DT cord-335975-m6lkrehi 4518 2 is be VBZ cord-335975-m6lkrehi 4518 3 a a DT cord-335975-m6lkrehi 4518 4 single single JJ cord-335975-m6lkrehi 4518 5 center center NN cord-335975-m6lkrehi 4518 6 study study NN cord-335975-m6lkrehi 4518 7 realized realize VBD cord-335975-m6lkrehi 4518 8 in in IN cord-335975-m6lkrehi 4518 9 a a DT cord-335975-m6lkrehi 4518 10 university university NN cord-335975-m6lkrehi 4518 11 ICU icu NN cord-335975-m6lkrehi 4518 12 of of IN cord-335975-m6lkrehi 4518 13 10 10 CD cord-335975-m6lkrehi 4518 14 beds bed NNS cord-335975-m6lkrehi 4518 15 . . . cord-335975-m6lkrehi 4519 1 Total total JJ cord-335975-m6lkrehi 4519 2 testosterone testosterone NN cord-335975-m6lkrehi 4519 3 levels level NNS cord-335975-m6lkrehi 4519 4 were be VBD cord-335975-m6lkrehi 4519 5 measured measure VBN cord-335975-m6lkrehi 4519 6 in in IN cord-335975-m6lkrehi 4519 7 critical critical JJ cord-335975-m6lkrehi 4519 8 ill ill JJ cord-335975-m6lkrehi 4519 9 men man NNS cord-335975-m6lkrehi 4519 10 with with IN cord-335975-m6lkrehi 4519 11 at at RB cord-335975-m6lkrehi 4519 12 least least RBS cord-335975-m6lkrehi 4519 13 one one CD cord-335975-m6lkrehi 4519 14 organ organ NN cord-335975-m6lkrehi 4519 15 dysfunction dysfunction NN cord-335975-m6lkrehi 4519 16 with with IN cord-335975-m6lkrehi 4519 17 SOFA SOFA NNP cord-335975-m6lkrehi 4519 18 > > SYM cord-335975-m6lkrehi 4519 19 3 3 CD cord-335975-m6lkrehi 4519 20 . . . cord-335975-m6lkrehi 4520 1 The the DT cord-335975-m6lkrehi 4520 2 study study NN cord-335975-m6lkrehi 4520 3 drug drug NN cord-335975-m6lkrehi 4520 4 was be VBD cord-335975-m6lkrehi 4520 5 Androgel Androgel NNP cord-335975-m6lkrehi 4520 6 , , , cord-335975-m6lkrehi 4520 7 a a DT cord-335975-m6lkrehi 4520 8 formulation formulation NN cord-335975-m6lkrehi 4520 9 of of IN cord-335975-m6lkrehi 4520 10 1 1 CD cord-335975-m6lkrehi 4520 11 % % NN cord-335975-m6lkrehi 4520 12 testosterone testosterone NN cord-335975-m6lkrehi 4520 13 in in IN cord-335975-m6lkrehi 4520 14 an an DT cord-335975-m6lkrehi 4520 15 alcohol alcohol NN cord-335975-m6lkrehi 4520 16 - - HYPH cord-335975-m6lkrehi 4520 17 water water NN cord-335975-m6lkrehi 4520 18 gel gel NN cord-335975-m6lkrehi 4520 19 , , , cord-335975-m6lkrehi 4520 20 approved approve VBN cord-335975-m6lkrehi 4520 21 by by IN cord-335975-m6lkrehi 4520 22 the the DT cord-335975-m6lkrehi 4520 23 ANSM ANSM NNP cord-335975-m6lkrehi 4520 24 for for IN cord-335975-m6lkrehi 4520 25 treatment treatment NN cord-335975-m6lkrehi 4520 26 of of IN cord-335975-m6lkrehi 4520 27 hypogonadism hypogonadism NN cord-335975-m6lkrehi 4520 28 in in IN cord-335975-m6lkrehi 4520 29 men man NNS cord-335975-m6lkrehi 4520 30 . . . cord-335975-m6lkrehi 4521 1 AndroGel AndroGel NNP cord-335975-m6lkrehi 4521 2 was be VBD cord-335975-m6lkrehi 4521 3 applied apply VBN cord-335975-m6lkrehi 4521 4 to to IN cord-335975-m6lkrehi 4521 5 the the DT cord-335975-m6lkrehi 4521 6 abdomen abdomen NN cord-335975-m6lkrehi 4521 7 , , , cord-335975-m6lkrehi 4521 8 shoulders shoulder NNS cord-335975-m6lkrehi 4521 9 or or CC cord-335975-m6lkrehi 4521 10 upper upper JJ cord-335975-m6lkrehi 4521 11 arms arm NNS cord-335975-m6lkrehi 4521 12 once once RB cord-335975-m6lkrehi 4521 13 a a DT cord-335975-m6lkrehi 4521 14 day day NN cord-335975-m6lkrehi 4521 15 at at IN cord-335975-m6lkrehi 4521 16 the the DT cord-335975-m6lkrehi 4521 17 same same JJ cord-335975-m6lkrehi 4521 18 time time NN cord-335975-m6lkrehi 4521 19 to to TO cord-335975-m6lkrehi 4521 20 dry dry VB cord-335975-m6lkrehi 4521 21 and and CC cord-335975-m6lkrehi 4521 22 intact intact JJ cord-335975-m6lkrehi 4521 23 skin skin NN cord-335975-m6lkrehi 4521 24 during during IN cord-335975-m6lkrehi 4521 25 ICU ICU NNP cord-335975-m6lkrehi 4521 26 stay stay NN cord-335975-m6lkrehi 4521 27 . . . cord-335975-m6lkrehi 4522 1 The the DT cord-335975-m6lkrehi 4522 2 daily daily JJ cord-335975-m6lkrehi 4522 3 dose dose NN cord-335975-m6lkrehi 4522 4 was be VBD cord-335975-m6lkrehi 4522 5 75 75 CD cord-335975-m6lkrehi 4522 6 mg mg NN cord-335975-m6lkrehi 4522 7 in in IN cord-335975-m6lkrehi 4522 8 men man NNS cord-335975-m6lkrehi 4522 9 and and CC cord-335975-m6lkrehi 4522 10 25 25 CD cord-335975-m6lkrehi 4522 11 mg mg NNS cord-335975-m6lkrehi 4522 12 in in IN cord-335975-m6lkrehi 4522 13 women woman NNS cord-335975-m6lkrehi 4522 14 daily daily RB cord-335975-m6lkrehi 4522 15 . . . cord-335975-m6lkrehi 4523 1 Patients patient NNS cord-335975-m6lkrehi 4523 2 with with IN cord-335975-m6lkrehi 4523 3 history history NN cord-335975-m6lkrehi 4523 4 of of IN cord-335975-m6lkrehi 4523 5 prostate prostate NN cord-335975-m6lkrehi 4523 6 or or CC cord-335975-m6lkrehi 4523 7 breast breast NN cord-335975-m6lkrehi 4523 8 cancer cancer NN cord-335975-m6lkrehi 4523 9 or or CC cord-335975-m6lkrehi 4523 10 PSA PSA NNP cord-335975-m6lkrehi 4523 11 > > XX cord-335975-m6lkrehi 4524 1 4 4 CD cord-335975-m6lkrehi 4524 2 ng ng NNP cord-335975-m6lkrehi 4524 3 ml ml NNS cord-335975-m6lkrehi 4524 4 were be VBD cord-335975-m6lkrehi 4524 5 excluded exclude VBN cord-335975-m6lkrehi 4524 6 . . . cord-335975-m6lkrehi 4525 1 Results result NNS cord-335975-m6lkrehi 4525 2 : : : cord-335975-m6lkrehi 4525 3 Total total JJ cord-335975-m6lkrehi 4525 4 testosterone testosterone NN cord-335975-m6lkrehi 4525 5 levels level NNS cord-335975-m6lkrehi 4525 6 were be VBD cord-335975-m6lkrehi 4525 7 measured measure VBN cord-335975-m6lkrehi 4525 8 in in IN cord-335975-m6lkrehi 4525 9 19 19 CD cord-335975-m6lkrehi 4525 10 men man NNS cord-335975-m6lkrehi 4525 11 . . . cord-335975-m6lkrehi 4526 1 Median median JJ cord-335975-m6lkrehi 4526 2 length length NN cord-335975-m6lkrehi 4526 3 of of IN cord-335975-m6lkrehi 4526 4 stay stay NN cord-335975-m6lkrehi 4526 5 at at IN cord-335975-m6lkrehi 4526 6 the the DT cord-335975-m6lkrehi 4526 7 time time NN cord-335975-m6lkrehi 4526 8 of of IN cord-335975-m6lkrehi 4526 9 measurement measurement NN cord-335975-m6lkrehi 4526 10 was be VBD cord-335975-m6lkrehi 4526 11 7 7 CD cord-335975-m6lkrehi 4526 12 days day NNS cord-335975-m6lkrehi 4526 13 in in IN cord-335975-m6lkrehi 4526 14 ICU ICU NNP cord-335975-m6lkrehi 4526 15 and and CC cord-335975-m6lkrehi 4526 16 11 11 CD cord-335975-m6lkrehi 4526 17 days day NNS cord-335975-m6lkrehi 4526 18 in in IN cord-335975-m6lkrehi 4526 19 the the DT cord-335975-m6lkrehi 4526 20 hospital hospital NN cord-335975-m6lkrehi 4526 21 . . . cord-335975-m6lkrehi 4527 1 Plasma plasma NN cord-335975-m6lkrehi 4527 2 testosterone testosterone NN cord-335975-m6lkrehi 4527 3 levels level NNS cord-335975-m6lkrehi 4527 4 were be VBD cord-335975-m6lkrehi 4527 5 low low JJ cord-335975-m6lkrehi 4527 6 in in IN cord-335975-m6lkrehi 4527 7 all all DT cord-335975-m6lkrehi 4527 8 but but CC cord-335975-m6lkrehi 4527 9 1 1 CD cord-335975-m6lkrehi 4527 10 patient patient NN cord-335975-m6lkrehi 4527 11 . . . cord-335975-m6lkrehi 4528 1 Median median JJ cord-335975-m6lkrehi 4528 2 testosterone testosterone NN cord-335975-m6lkrehi 4528 3 level level NN cord-335975-m6lkrehi 4528 4 was be VBD cord-335975-m6lkrehi 4528 5 58 58 CD cord-335975-m6lkrehi 4528 6 ng ng NN cord-335975-m6lkrehi 4528 7 dl dl NN cord-335975-m6lkrehi 4528 8 ( ( -LRB- cord-335975-m6lkrehi 4528 9 normal normal JJ cord-335975-m6lkrehi 4528 10 values value NNS cord-335975-m6lkrehi 4528 11 270 270 CD cord-335975-m6lkrehi 4528 12 - - SYM cord-335975-m6lkrehi 4528 13 780 780 CD cord-335975-m6lkrehi 4528 14 ng ng NN cord-335975-m6lkrehi 4528 15 dl dl NN cord-335975-m6lkrehi 4528 16 ) ) -RRB- cord-335975-m6lkrehi 4528 17 . . . cord-335975-m6lkrehi 4529 1 Testosterone testosterone NN cord-335975-m6lkrehi 4529 2 levels level NNS cord-335975-m6lkrehi 4529 3 were be VBD cord-335975-m6lkrehi 4529 4 not not RB cord-335975-m6lkrehi 4529 5 correlated correlate VBN cord-335975-m6lkrehi 4529 6 with with IN cord-335975-m6lkrehi 4529 7 score score NN cord-335975-m6lkrehi 4529 8 SOFA sofa NN cord-335975-m6lkrehi 4529 9 or or CC cord-335975-m6lkrehi 4529 10 length length NN cord-335975-m6lkrehi 4529 11 of of IN cord-335975-m6lkrehi 4529 12 ICU ICU NNP cord-335975-m6lkrehi 4529 13 stay stay NN cord-335975-m6lkrehi 4529 14 . . . cord-335975-m6lkrehi 4530 1 We -PRON- PRP cord-335975-m6lkrehi 4530 2 found find VBD cord-335975-m6lkrehi 4530 3 a a DT cord-335975-m6lkrehi 4530 4 moderate moderate JJ cord-335975-m6lkrehi 4530 5 positif positif NNP cord-335975-m6lkrehi 4530 6 correlation correlation NN cord-335975-m6lkrehi 4530 7 between between IN cord-335975-m6lkrehi 4530 8 testosterone testosterone NN cord-335975-m6lkrehi 4530 9 levels level NNS cord-335975-m6lkrehi 4530 10 and and CC cord-335975-m6lkrehi 4530 11 length length NN cord-335975-m6lkrehi 4530 12 of of IN cord-335975-m6lkrehi 4530 13 hospital hospital NN cord-335975-m6lkrehi 4530 14 stay stay NN cord-335975-m6lkrehi 4531 1 ( ( -LRB- cord-335975-m6lkrehi 4531 2 r r NN cord-335975-m6lkrehi 4531 3 = = SYM cord-335975-m6lkrehi 4531 4 0.5 0.5 CD cord-335975-m6lkrehi 4531 5 =) =) UH cord-335975-m6lkrehi 4531 6 . . . cord-335975-m6lkrehi 4532 1 Testosterone testosterone NN cord-335975-m6lkrehi 4532 2 gel gel NN cord-335975-m6lkrehi 4532 3 was be VBD cord-335975-m6lkrehi 4532 4 administered administer VBN cord-335975-m6lkrehi 4532 5 in in IN cord-335975-m6lkrehi 4532 6 12 12 CD cord-335975-m6lkrehi 4532 7 men man NNS cord-335975-m6lkrehi 4532 8 and and CC cord-335975-m6lkrehi 4532 9 in in IN cord-335975-m6lkrehi 4532 10 6 6 CD cord-335975-m6lkrehi 4532 11 women woman NNS cord-335975-m6lkrehi 4532 12 . . . cord-335975-m6lkrehi 4533 1 In in IN cord-335975-m6lkrehi 4533 2 these these DT cord-335975-m6lkrehi 4533 3 18 18 CD cord-335975-m6lkrehi 4533 4 patients patient NNS cord-335975-m6lkrehi 4533 5 , , , cord-335975-m6lkrehi 4533 6 the the DT cord-335975-m6lkrehi 4533 7 median median JJ cord-335975-m6lkrehi 4533 8 score score NN cord-335975-m6lkrehi 4533 9 SOFA sofa NN cord-335975-m6lkrehi 4533 10 was be VBD cord-335975-m6lkrehi 4533 11 10 10 CD cord-335975-m6lkrehi 4533 12 , , , cord-335975-m6lkrehi 4533 13 ICU ICU NNP cord-335975-m6lkrehi 4533 14 death death NN cord-335975-m6lkrehi 4533 15 occurred occur VBD cord-335975-m6lkrehi 4533 16 in in IN cord-335975-m6lkrehi 4533 17 3 3 CD cord-335975-m6lkrehi 4533 18 patients patient NNS cord-335975-m6lkrehi 4533 19 ( ( -LRB- cord-335975-m6lkrehi 4533 20 22 22 CD cord-335975-m6lkrehi 4533 21 % % NN cord-335975-m6lkrehi 4533 22 ICU ICU NNP cord-335975-m6lkrehi 4533 23 mortality mortality NN cord-335975-m6lkrehi 4533 24 ) ) -RRB- cord-335975-m6lkrehi 4533 25 , , , cord-335975-m6lkrehi 4533 26 median median JJ cord-335975-m6lkrehi 4533 27 length length NN cord-335975-m6lkrehi 4533 28 of of IN cord-335975-m6lkrehi 4533 29 ventilation ventilation NN cord-335975-m6lkrehi 4533 30 was be VBD cord-335975-m6lkrehi 4533 31 13 13 CD cord-335975-m6lkrehi 4533 32 days day NNS cord-335975-m6lkrehi 4533 33 and and CC cord-335975-m6lkrehi 4533 34 median median JJ cord-335975-m6lkrehi 4533 35 length length NN cord-335975-m6lkrehi 4533 36 of of IN cord-335975-m6lkrehi 4533 37 stay stay NN cord-335975-m6lkrehi 4533 38 in in IN cord-335975-m6lkrehi 4533 39 ICU ICU NNP cord-335975-m6lkrehi 4533 40 30 30 CD cord-335975-m6lkrehi 4533 41 days day NNS cord-335975-m6lkrehi 4533 42 . . . cord-335975-m6lkrehi 4534 1 All all DT cord-335975-m6lkrehi 4534 2 patients patient NNS cord-335975-m6lkrehi 4534 3 received receive VBD cord-335975-m6lkrehi 4534 4 mechanical mechanical JJ cord-335975-m6lkrehi 4534 5 ventilation ventilation NN cord-335975-m6lkrehi 4534 6 and and CC cord-335975-m6lkrehi 4534 7 vasoactive vasoactive JJ cord-335975-m6lkrehi 4534 8 treatment treatment NN cord-335975-m6lkrehi 4534 9 . . . cord-335975-m6lkrehi 4535 1 9 9 CD cord-335975-m6lkrehi 4535 2 patients patient NNS cord-335975-m6lkrehi 4535 3 needed need VBD cord-335975-m6lkrehi 4535 4 renal renal JJ cord-335975-m6lkrehi 4535 5 replacement replacement NN cord-335975-m6lkrehi 4535 6 therapy therapy NN cord-335975-m6lkrehi 4535 7 . . . cord-335975-m6lkrehi 4536 1 AndroGel AndroGel NNP cord-335975-m6lkrehi 4536 2 was be VBD cord-335975-m6lkrehi 4536 3 well well RB cord-335975-m6lkrehi 4536 4 tolerated tolerate VBN cord-335975-m6lkrehi 4536 5 . . . cord-335975-m6lkrehi 4537 1 No no DT cord-335975-m6lkrehi 4537 2 ischemic ischemic JJ cord-335975-m6lkrehi 4537 3 cardiovascular cardiovascular JJ cord-335975-m6lkrehi 4537 4 events event NNS cord-335975-m6lkrehi 4537 5 were be VBD cord-335975-m6lkrehi 4537 6 described describe VBN cord-335975-m6lkrehi 4537 7 . . . cord-335975-m6lkrehi 4538 1 There there EX cord-335975-m6lkrehi 4538 2 was be VBD cord-335975-m6lkrehi 4538 3 no no DT cord-335975-m6lkrehi 4538 4 application application NN cord-335975-m6lkrehi 4538 5 site site NN cord-335975-m6lkrehi 4538 6 reaction reaction NN cord-335975-m6lkrehi 4538 7 or or CC cord-335975-m6lkrehi 4538 8 acne acne NN cord-335975-m6lkrehi 4538 9 . . . cord-335975-m6lkrehi 4539 1 Median median JJ cord-335975-m6lkrehi 4539 2 length length NN cord-335975-m6lkrehi 4539 3 of of IN cord-335975-m6lkrehi 4539 4 testosterone testosterone NN cord-335975-m6lkrehi 4539 5 gel gel NN cord-335975-m6lkrehi 4539 6 administration administration NN cord-335975-m6lkrehi 4539 7 was be VBD cord-335975-m6lkrehi 4539 8 12 12 CD cord-335975-m6lkrehi 4539 9 days day NNS cord-335975-m6lkrehi 4539 10 . . . cord-335975-m6lkrehi 4540 1 Conclusion conclusion NN cord-335975-m6lkrehi 4540 2 : : : cord-335975-m6lkrehi 4541 1 Critical critical JJ cord-335975-m6lkrehi 4541 2 ill ill JJ cord-335975-m6lkrehi 4541 3 patients patient NNS cord-335975-m6lkrehi 4541 4 have have VBP cord-335975-m6lkrehi 4541 5 low low JJ cord-335975-m6lkrehi 4541 6 testosterone testosterone NN cord-335975-m6lkrehi 4541 7 levels level NNS cord-335975-m6lkrehi 4541 8 . . . cord-335975-m6lkrehi 4542 1 Testosterone testosterone NN cord-335975-m6lkrehi 4542 2 gel gel NN cord-335975-m6lkrehi 4542 3 may may MD cord-335975-m6lkrehi 4542 4 be be VB cord-335975-m6lkrehi 4542 5 safely safely RB cord-335975-m6lkrehi 4542 6 administered administer VBN cord-335975-m6lkrehi 4542 7 during during IN cord-335975-m6lkrehi 4542 8 the the DT cord-335975-m6lkrehi 4542 9 acute acute JJ cord-335975-m6lkrehi 4542 10 phase phase NN cord-335975-m6lkrehi 4542 11 in in IN cord-335975-m6lkrehi 4542 12 ICU ICU NNP cord-335975-m6lkrehi 4542 13 . . . cord-335975-m6lkrehi 4543 1 Randomized randomized JJ cord-335975-m6lkrehi 4543 2 clinical clinical JJ cord-335975-m6lkrehi 4543 3 trials trial NNS cord-335975-m6lkrehi 4543 4 are be VBP cord-335975-m6lkrehi 4543 5 needed need VBN cord-335975-m6lkrehi 4543 6 to to TO cord-335975-m6lkrehi 4543 7 evaluate evaluate VB cord-335975-m6lkrehi 4543 8 the the DT cord-335975-m6lkrehi 4543 9 impact impact NN cord-335975-m6lkrehi 4543 10 of of IN cord-335975-m6lkrehi 4543 11 testosterone testosterone NN cord-335975-m6lkrehi 4543 12 gel gel NN cord-335975-m6lkrehi 4543 13 on on IN cord-335975-m6lkrehi 4543 14 physical physical JJ cord-335975-m6lkrehi 4543 15 performance performance NN cord-335975-m6lkrehi 4543 16 . . . cord-335975-m6lkrehi 4544 1 Introduction introduction NN cord-335975-m6lkrehi 4544 2 : : : cord-335975-m6lkrehi 4545 1 Stroke stroke NN cord-335975-m6lkrehi 4545 2 is be VBZ cord-335975-m6lkrehi 4545 3 the the DT cord-335975-m6lkrehi 4545 4 leading leading JJ cord-335975-m6lkrehi 4545 5 cause cause NN cord-335975-m6lkrehi 4545 6 of of IN cord-335975-m6lkrehi 4545 7 physical physical JJ cord-335975-m6lkrehi 4545 8 disability disability NN cord-335975-m6lkrehi 4545 9 and and CC cord-335975-m6lkrehi 4545 10 the the DT cord-335975-m6lkrehi 4545 11 second second JJ cord-335975-m6lkrehi 4545 12 leading leading JJ cord-335975-m6lkrehi 4545 13 cause cause NN cord-335975-m6lkrehi 4545 14 of of IN cord-335975-m6lkrehi 4545 15 death death NN cord-335975-m6lkrehi 4545 16 worldwide worldwide RB cord-335975-m6lkrehi 4545 17 . . . cord-335975-m6lkrehi 4546 1 Two two CD cord-335975-m6lkrehi 4546 2 thirds third NNS cord-335975-m6lkrehi 4546 3 of of IN cord-335975-m6lkrehi 4546 4 all all DT cord-335975-m6lkrehi 4546 5 strokes stroke NNS cord-335975-m6lkrehi 4546 6 occur occur VBP cord-335975-m6lkrehi 4546 7 in in IN cord-335975-m6lkrehi 4546 8 developing develop VBG cord-335975-m6lkrehi 4546 9 countries country NNS cord-335975-m6lkrehi 4546 10 and and CC cord-335975-m6lkrehi 4546 11 is be VBZ cord-335975-m6lkrehi 4546 12 increasingly increasingly RB cord-335975-m6lkrehi 4546 13 a a DT cord-335975-m6lkrehi 4546 14 public public JJ cord-335975-m6lkrehi 4546 15 health health NN cord-335975-m6lkrehi 4546 16 problem problem NN cord-335975-m6lkrehi 4546 17 . . . cord-335975-m6lkrehi 4547 1 The the DT cord-335975-m6lkrehi 4547 2 aim aim NN cord-335975-m6lkrehi 4547 3 of of IN cord-335975-m6lkrehi 4547 4 this this DT cord-335975-m6lkrehi 4547 5 study study NN cord-335975-m6lkrehi 4547 6 was be VBD cord-335975-m6lkrehi 4547 7 to to TO cord-335975-m6lkrehi 4547 8 evaluate evaluate VB cord-335975-m6lkrehi 4547 9 the the DT cord-335975-m6lkrehi 4547 10 epidemiology epidemiology NN cord-335975-m6lkrehi 4547 11 of of IN cord-335975-m6lkrehi 4547 12 strokes stroke NNS cord-335975-m6lkrehi 4547 13 in in IN cord-335975-m6lkrehi 4547 14 Oran Oran NNP cord-335975-m6lkrehi 4547 15 , , , cord-335975-m6lkrehi 4547 16 Algeria Algeria NNP cord-335975-m6lkrehi 4547 17 in in IN cord-335975-m6lkrehi 4547 18 order order NN cord-335975-m6lkrehi 4547 19 to to TO cord-335975-m6lkrehi 4547 20 create create VB cord-335975-m6lkrehi 4547 21 a a DT cord-335975-m6lkrehi 4547 22 stroke stroke NN cord-335975-m6lkrehi 4547 23 registry registry NN cord-335975-m6lkrehi 4547 24 . . . cord-335975-m6lkrehi 4548 1 Patients patient NNS cord-335975-m6lkrehi 4548 2 and and CC cord-335975-m6lkrehi 4548 3 methods method NNS cord-335975-m6lkrehi 4548 4 : : : cord-335975-m6lkrehi 4548 5 A a DT cord-335975-m6lkrehi 4548 6 cross cross JJ cord-335975-m6lkrehi 4548 7 - - JJ cord-335975-m6lkrehi 4548 8 sectional sectional JJ cord-335975-m6lkrehi 4548 9 study study NN cord-335975-m6lkrehi 4548 10 was be VBD cord-335975-m6lkrehi 4548 11 conducted conduct VBN cord-335975-m6lkrehi 4548 12 on on IN cord-335975-m6lkrehi 4548 13 all all DT cord-335975-m6lkrehi 4548 14 patients patient NNS cord-335975-m6lkrehi 4548 15 admitted admit VBN cord-335975-m6lkrehi 4548 16 for for IN cord-335975-m6lkrehi 4548 17 stroke stroke NN cord-335975-m6lkrehi 4548 18 at at IN cord-335975-m6lkrehi 4548 19 the the DT cord-335975-m6lkrehi 4548 20 Oran Oran NNP cord-335975-m6lkrehi 4548 21 CHU CHU NNP cord-335975-m6lkrehi 4548 22 between between IN cord-335975-m6lkrehi 4548 23 January January NNP cord-335975-m6lkrehi 4548 24 2014 2014 CD cord-335975-m6lkrehi 4548 25 and and CC cord-335975-m6lkrehi 4548 26 September September NNP cord-335975-m6lkrehi 4548 27 2017 2017 CD cord-335975-m6lkrehi 4548 28 . . . cord-335975-m6lkrehi 4549 1 Sociodemographic sociodemographic JJ cord-335975-m6lkrehi 4549 2 data datum NNS cord-335975-m6lkrehi 4549 3 , , , cord-335975-m6lkrehi 4549 4 modifiable modifiable JJ cord-335975-m6lkrehi 4549 5 and and CC cord-335975-m6lkrehi 4549 6 nomodifiable nomodifiable JJ cord-335975-m6lkrehi 4549 7 risk risk NN cord-335975-m6lkrehi 4549 8 factors factor NNS cord-335975-m6lkrehi 4549 9 , , , cord-335975-m6lkrehi 4549 10 type type NN cord-335975-m6lkrehi 4549 11 of of IN cord-335975-m6lkrehi 4549 12 stroke stroke NN cord-335975-m6lkrehi 4549 13 , , , cord-335975-m6lkrehi 4549 14 degree degree NN cord-335975-m6lkrehi 4549 15 of of IN cord-335975-m6lkrehi 4549 16 disability disability NN cord-335975-m6lkrehi 4549 17 , , , cord-335975-m6lkrehi 4549 18 Severity severity NN cord-335975-m6lkrehi 4549 19 scores score NNS cord-335975-m6lkrehi 4549 20 ( ( -LRB- cord-335975-m6lkrehi 4549 21 GLASGOW GLASGOW NNP cord-335975-m6lkrehi 4549 22 and and CC cord-335975-m6lkrehi 4549 23 NIHSS NIHSS NNP cord-335975-m6lkrehi 4549 24 ) ) -RRB- cord-335975-m6lkrehi 4549 25 were be VBD cord-335975-m6lkrehi 4549 26 studied study VBN cord-335975-m6lkrehi 4549 27 . . . cord-335975-m6lkrehi 4550 1 The the DT cord-335975-m6lkrehi 4550 2 SPSS SPSS NNP cord-335975-m6lkrehi 4550 3 20 20 CD cord-335975-m6lkrehi 4550 4 software software NN cord-335975-m6lkrehi 4550 5 , , , cord-335975-m6lkrehi 4550 6 Log Log NNP cord-335975-m6lkrehi 4550 7 Rank Rank NNP cord-335975-m6lkrehi 4550 8 test test NN cord-335975-m6lkrehi 4550 9 , , , cord-335975-m6lkrehi 4550 10 was be VBD cord-335975-m6lkrehi 4550 11 used use VBN cord-335975-m6lkrehi 4550 12 for for IN cord-335975-m6lkrehi 4550 13 data datum NNS cord-335975-m6lkrehi 4550 14 analysis analysis NN cord-335975-m6lkrehi 4550 15 and and CC cord-335975-m6lkrehi 4550 16 statistical statistical JJ cord-335975-m6lkrehi 4550 17 testing testing NN cord-335975-m6lkrehi 4550 18 as as RB cord-335975-m6lkrehi 4550 19 well well RB cord-335975-m6lkrehi 4550 20 as as IN cord-335975-m6lkrehi 4550 21 kaplan kaplan NNP cord-335975-m6lkrehi 4550 22 - - HYPH cord-335975-m6lkrehi 4550 23 meier meier NNP cord-335975-m6lkrehi 4550 24 for for IN cord-335975-m6lkrehi 4550 25 survival survival NN cord-335975-m6lkrehi 4550 26 studies study NNS cord-335975-m6lkrehi 4550 27 . . . cord-335975-m6lkrehi 4551 1 Results result NNS cord-335975-m6lkrehi 4551 2 : : : cord-335975-m6lkrehi 4552 1 A a DT cord-335975-m6lkrehi 4552 2 total total NN cord-335975-m6lkrehi 4552 3 of of IN cord-335975-m6lkrehi 4552 4 2305 2305 CD cord-335975-m6lkrehi 4552 5 stroke stroke NN cord-335975-m6lkrehi 4552 6 patients patient NNS cord-335975-m6lkrehi 4552 7 were be VBD cord-335975-m6lkrehi 4552 8 enumerated enumerate VBN cord-335975-m6lkrehi 4552 9 , , , cord-335975-m6lkrehi 4552 10 aged aged JJ cord-335975-m6lkrehi 4552 11 20 20 CD cord-335975-m6lkrehi 4552 12 - - SYM cord-335975-m6lkrehi 4552 13 99 99 CD cord-335975-m6lkrehi 4552 14 years year NNS cord-335975-m6lkrehi 4553 1 ( ( -LRB- cord-335975-m6lkrehi 4553 2 mean mean VB cord-335975-m6lkrehi 4554 1 ± ± NNP cord-335975-m6lkrehi 4554 2 SD sd NN cord-335975-m6lkrehi 4554 3 = = NFP cord-335975-m6lkrehi 4555 1 68.33 68.33 CD cord-335975-m6lkrehi 4555 2 ± ± CD cord-335975-m6lkrehi 4555 3 12.99 12.99 CD cord-335975-m6lkrehi 4555 4 ) ) -RRB- cord-335975-m6lkrehi 4555 5 , , , cord-335975-m6lkrehi 4555 6 74.2 74.2 CD cord-335975-m6lkrehi 4555 7 % % NN cord-335975-m6lkrehi 4555 8 had have VBD cord-335975-m6lkrehi 4555 9 an an DT cord-335975-m6lkrehi 4555 10 ischemic ischemic JJ cord-335975-m6lkrehi 4555 11 stroke stroke NN cord-335975-m6lkrehi 4555 12 and and CC cord-335975-m6lkrehi 4555 13 15 15 CD cord-335975-m6lkrehi 4555 14 % % NN cord-335975-m6lkrehi 4555 15 had have VBD cord-335975-m6lkrehi 4555 16 a a DT cord-335975-m6lkrehi 4555 17 haemorrhagic haemorrhagic JJ cord-335975-m6lkrehi 4555 18 stroke stroke NN cord-335975-m6lkrehi 4555 19 . . . cord-335975-m6lkrehi 4556 1 49 49 CD cord-335975-m6lkrehi 4556 2 % % NN cord-335975-m6lkrehi 4556 3 of of IN cord-335975-m6lkrehi 4556 4 the the DT cord-335975-m6lkrehi 4556 5 patients patient NNS cord-335975-m6lkrehi 4556 6 were be VBD cord-335975-m6lkrehi 4556 7 men man NNS cord-335975-m6lkrehi 4556 8 and and CC cord-335975-m6lkrehi 4556 9 51 51 CD cord-335975-m6lkrehi 4556 10 % % NN cord-335975-m6lkrehi 4556 11 of of IN cord-335975-m6lkrehi 4556 12 the the DT cord-335975-m6lkrehi 4556 13 women woman NNS cord-335975-m6lkrehi 4556 14 . . . cord-335975-m6lkrehi 4557 1 High high JJ cord-335975-m6lkrehi 4557 2 blood blood NN cord-335975-m6lkrehi 4557 3 pressure pressure NN cord-335975-m6lkrehi 4557 4 , , , cord-335975-m6lkrehi 4557 5 diabetes diabetes NN cord-335975-m6lkrehi 4557 6 , , , cord-335975-m6lkrehi 4557 7 emboligenous emboligenous NNP cord-335975-m6lkrehi 4557 8 heart heart NN cord-335975-m6lkrehi 4557 9 disease disease NN cord-335975-m6lkrehi 4557 10 and and CC cord-335975-m6lkrehi 4557 11 smoking smoking NN cord-335975-m6lkrehi 4557 12 were be VBD cord-335975-m6lkrehi 4557 13 the the DT cord-335975-m6lkrehi 4557 14 most most RBS cord-335975-m6lkrehi 4557 15 common common JJ cord-335975-m6lkrehi 4557 16 risk risk NN cord-335975-m6lkrehi 4557 17 factors factor NNS cord-335975-m6lkrehi 4557 18 . . . cord-335975-m6lkrehi 4558 1 Intra intra JJ cord-335975-m6lkrehi 4558 2 - - JJ cord-335975-m6lkrehi 4558 3 hospital hospital JJ cord-335975-m6lkrehi 4558 4 mortality mortality NN cord-335975-m6lkrehi 4558 5 was be VBD cord-335975-m6lkrehi 4558 6 15.5 15.5 CD cord-335975-m6lkrehi 4558 7 % % NN cord-335975-m6lkrehi 4558 8 and and CC cord-335975-m6lkrehi 4558 9 the the DT cord-335975-m6lkrehi 4558 10 overall overall JJ cord-335975-m6lkrehi 4558 11 survival survival NN cord-335975-m6lkrehi 4558 12 rate rate NN cord-335975-m6lkrehi 4558 13 at at IN cord-335975-m6lkrehi 4558 14 28 28 CD cord-335975-m6lkrehi 4558 15 days day NNS cord-335975-m6lkrehi 4558 16 was be VBD cord-335975-m6lkrehi 4558 17 77 77 CD cord-335975-m6lkrehi 4558 18 % % NN cord-335975-m6lkrehi 4558 19 . . . cord-335975-m6lkrehi 4559 1 Conclusion conclusion NN cord-335975-m6lkrehi 4559 2 : : : cord-335975-m6lkrehi 4560 1 This this DT cord-335975-m6lkrehi 4560 2 epidemiological epidemiological JJ cord-335975-m6lkrehi 4560 3 study study NN cord-335975-m6lkrehi 4560 4 demonstrates demonstrate VBZ cord-335975-m6lkrehi 4560 5 that that IN cord-335975-m6lkrehi 4560 6 strokes stroke NNS cord-335975-m6lkrehi 4560 7 at at IN cord-335975-m6lkrehi 4560 8 Oran Oran NNP cord-335975-m6lkrehi 4560 9 Hospital Hospital NNP cord-335975-m6lkrehi 4560 10 may may MD cord-335975-m6lkrehi 4560 11 be be VB cord-335975-m6lkrehi 4560 12 similar similar JJ cord-335975-m6lkrehi 4560 13 to to IN cord-335975-m6lkrehi 4560 14 other other JJ cord-335975-m6lkrehi 4560 15 locations location NNS cord-335975-m6lkrehi 4560 16 . . . cord-335975-m6lkrehi 4561 1 However however RB cord-335975-m6lkrehi 4561 2 , , , cord-335975-m6lkrehi 4561 3 it -PRON- PRP cord-335975-m6lkrehi 4561 4 seems seem VBZ cord-335975-m6lkrehi 4561 5 necessary necessary JJ cord-335975-m6lkrehi 4561 6 and and CC cord-335975-m6lkrehi 4561 7 useful useful JJ cord-335975-m6lkrehi 4561 8 to to TO cord-335975-m6lkrehi 4561 9 design design VB cord-335975-m6lkrehi 4561 10 a a DT cord-335975-m6lkrehi 4561 11 continuous continuous JJ cord-335975-m6lkrehi 4561 12 patient patient NN cord-335975-m6lkrehi 4561 13 registration registration NN cord-335975-m6lkrehi 4561 14 system system NN cord-335975-m6lkrehi 4561 15 . . . cord-335975-m6lkrehi 4562 1 Introduction introduction NN cord-335975-m6lkrehi 4562 2 : : : cord-335975-m6lkrehi 4563 1 The the DT cord-335975-m6lkrehi 4563 2 prevalence prevalence NN cord-335975-m6lkrehi 4563 3 of of IN cord-335975-m6lkrehi 4563 4 hyperosmolar hyperosmolar JJ cord-335975-m6lkrehi 4563 5 states state NNS cord-335975-m6lkrehi 4563 6 and and CC cord-335975-m6lkrehi 4563 7 the the DT cord-335975-m6lkrehi 4563 8 relationship relationship NN cord-335975-m6lkrehi 4563 9 with with IN cord-335975-m6lkrehi 4563 10 mortality mortality NN cord-335975-m6lkrehi 4563 11 nevertheless nevertheless RB cord-335975-m6lkrehi 4563 12 remain remain VBP cord-335975-m6lkrehi 4563 13 unquantified unquantified JJ cord-335975-m6lkrehi 4563 14 and and CC cord-335975-m6lkrehi 4563 15 not not RB cord-335975-m6lkrehi 4563 16 objectively objectively RB cord-335975-m6lkrehi 4563 17 demonstrated demonstrate VBN cord-335975-m6lkrehi 4563 18 . . . cord-335975-m6lkrehi 4564 1 The the DT cord-335975-m6lkrehi 4564 2 aim aim NN cord-335975-m6lkrehi 4564 3 of of IN cord-335975-m6lkrehi 4564 4 this this DT cord-335975-m6lkrehi 4564 5 work work NN cord-335975-m6lkrehi 4564 6 is be VBZ cord-335975-m6lkrehi 4564 7 to to TO cord-335975-m6lkrehi 4564 8 determine determine VB cord-335975-m6lkrehi 4564 9 whether whether IN cord-335975-m6lkrehi 4564 10 hyperosmolarity hyperosmolarity NN cord-335975-m6lkrehi 4564 11 is be VBZ cord-335975-m6lkrehi 4564 12 a a DT cord-335975-m6lkrehi 4564 13 prognosis prognosis NN cord-335975-m6lkrehi 4564 14 factor factor NN cord-335975-m6lkrehi 4564 15 , , , cord-335975-m6lkrehi 4564 16 and and CC cord-335975-m6lkrehi 4564 17 to to TO cord-335975-m6lkrehi 4564 18 assess assess VB cord-335975-m6lkrehi 4564 19 the the DT cord-335975-m6lkrehi 4564 20 impact impact NN cord-335975-m6lkrehi 4564 21 of of IN cord-335975-m6lkrehi 4564 22 hyperosmolarity hyperosmolarity NN cord-335975-m6lkrehi 4564 23 on on IN cord-335975-m6lkrehi 4564 24 the the DT cord-335975-m6lkrehi 4564 25 evolution evolution NN cord-335975-m6lkrehi 4564 26 of of IN cord-335975-m6lkrehi 4564 27 patients patient NNS cord-335975-m6lkrehi 4564 28 . . . cord-335975-m6lkrehi 4565 1 Patients patient NNS cord-335975-m6lkrehi 4565 2 and and CC cord-335975-m6lkrehi 4565 3 methods method NNS cord-335975-m6lkrehi 4565 4 : : : cord-335975-m6lkrehi 4565 5 This this DT cord-335975-m6lkrehi 4565 6 is be VBZ cord-335975-m6lkrehi 4565 7 a a DT cord-335975-m6lkrehi 4565 8 retrospective retrospective JJ cord-335975-m6lkrehi 4565 9 descriptive descriptive JJ cord-335975-m6lkrehi 4565 10 and and CC cord-335975-m6lkrehi 4565 11 analytical analytical JJ cord-335975-m6lkrehi 4565 12 study study NN cord-335975-m6lkrehi 4565 13 performed perform VBN cord-335975-m6lkrehi 4565 14 at at IN cord-335975-m6lkrehi 4565 15 the the DT cord-335975-m6lkrehi 4565 16 medical medical JJ cord-335975-m6lkrehi 4565 17 intensive intensive JJ cord-335975-m6lkrehi 4565 18 care care NN cord-335975-m6lkrehi 4565 19 unit unit NN cord-335975-m6lkrehi 4565 20 at at IN cord-335975-m6lkrehi 4565 21 the the DT cord-335975-m6lkrehi 4565 22 university university NN cord-335975-m6lkrehi 4565 23 teaching teaching NN cord-335975-m6lkrehi 4565 24 hospital hospital NN cord-335975-m6lkrehi 4565 25 IBN IBN NNP cord-335975-m6lkrehi 4565 26 RUSHD RUSHD NNP cord-335975-m6lkrehi 4565 27 in in IN cord-335975-m6lkrehi 4565 28 Casablanca Casablanca NNP cord-335975-m6lkrehi 4565 29 on on IN cord-335975-m6lkrehi 4565 30 the the DT cord-335975-m6lkrehi 4565 31 cases case NNS cord-335975-m6lkrehi 4565 32 admitted admit VBN cord-335975-m6lkrehi 4565 33 during during IN cord-335975-m6lkrehi 4565 34 1 1 CD cord-335975-m6lkrehi 4565 35 year year NN cord-335975-m6lkrehi 4565 36 . . . cord-335975-m6lkrehi 4566 1 We -PRON- PRP cord-335975-m6lkrehi 4566 2 noted note VBD cord-335975-m6lkrehi 4566 3 epidemiological epidemiological JJ cord-335975-m6lkrehi 4566 4 , , , cord-335975-m6lkrehi 4566 5 clinical clinical JJ cord-335975-m6lkrehi 4566 6 , , , cord-335975-m6lkrehi 4566 7 biological biological JJ cord-335975-m6lkrehi 4566 8 and and CC cord-335975-m6lkrehi 4566 9 evolutionary evolutionary JJ cord-335975-m6lkrehi 4566 10 parameters parameter NNS cord-335975-m6lkrehi 4566 11 of of IN cord-335975-m6lkrehi 4566 12 all all PDT cord-335975-m6lkrehi 4566 13 the the DT cord-335975-m6lkrehi 4566 14 patients patient NNS cord-335975-m6lkrehi 4566 15 and and CC cord-335975-m6lkrehi 4566 16 divided divide VBD cord-335975-m6lkrehi 4566 17 them -PRON- PRP cord-335975-m6lkrehi 4566 18 into into IN cord-335975-m6lkrehi 4566 19 two two CD cord-335975-m6lkrehi 4566 20 groups group NNS cord-335975-m6lkrehi 4566 21 according accord VBG cord-335975-m6lkrehi 4566 22 to to IN cord-335975-m6lkrehi 4566 23 their -PRON- PRP$ cord-335975-m6lkrehi 4566 24 osmolar osmolar JJ cord-335975-m6lkrehi 4566 25 states state NNS cord-335975-m6lkrehi 4566 26 , , , cord-335975-m6lkrehi 4566 27 the the DT cord-335975-m6lkrehi 4566 28 first first JJ cord-335975-m6lkrehi 4566 29 non non JJ cord-335975-m6lkrehi 4566 30 - - JJ cord-335975-m6lkrehi 4566 31 hyperosmolar hyperosmolar JJ cord-335975-m6lkrehi 4566 32 group group NN cord-335975-m6lkrehi 4566 33 with with IN cord-335975-m6lkrehi 4566 34 plasma plasma NN cord-335975-m6lkrehi 4566 35 osmolarity osmolarity NN cord-335975-m6lkrehi 4566 36 of of IN cord-335975-m6lkrehi 4566 37 less less JJR cord-335975-m6lkrehi 4566 38 than than IN cord-335975-m6lkrehi 4566 39 320 320 CD cord-335975-m6lkrehi 4566 40 mOsm mOsm NNP cord-335975-m6lkrehi 4566 41 L L NNP cord-335975-m6lkrehi 4566 42 , , , cord-335975-m6lkrehi 4566 43 called call VBD cord-335975-m6lkrehi 4566 44 the the DT cord-335975-m6lkrehi 4566 45 control control NN cord-335975-m6lkrehi 4566 46 group group NN cord-335975-m6lkrehi 4566 47 and and CC cord-335975-m6lkrehi 4566 48 the the DT cord-335975-m6lkrehi 4566 49 second second JJ cord-335975-m6lkrehi 4566 50 hyperosmolar hyperosmolar NNP cord-335975-m6lkrehi 4566 51 group group NN cord-335975-m6lkrehi 4566 52 , , , cord-335975-m6lkrehi 4566 53 plasma plasma NN cord-335975-m6lkrehi 4566 54 osmolarity osmolarity NN cord-335975-m6lkrehi 4566 55 greater great JJR cord-335975-m6lkrehi 4566 56 than than IN cord-335975-m6lkrehi 4566 57 or or CC cord-335975-m6lkrehi 4566 58 equal equal JJ cord-335975-m6lkrehi 4566 59 to to IN cord-335975-m6lkrehi 4566 60 320 320 CD cord-335975-m6lkrehi 4566 61 mOsm mOsm NNP cord-335975-m6lkrehi 4566 62 L. L. NNP cord-335975-m6lkrehi 4566 63 Results result NNS cord-335975-m6lkrehi 4566 64 : : : cord-335975-m6lkrehi 4566 65 371 371 CD cord-335975-m6lkrehi 4566 66 patients patient NNS cord-335975-m6lkrehi 4566 67 were be VBD cord-335975-m6lkrehi 4566 68 included include VBN cord-335975-m6lkrehi 4566 69 . . . cord-335975-m6lkrehi 4567 1 The the DT cord-335975-m6lkrehi 4567 2 first first JJ cord-335975-m6lkrehi 4567 3 group group NN cord-335975-m6lkrehi 4567 4 comprised comprise VBD cord-335975-m6lkrehi 4567 5 293 293 CD cord-335975-m6lkrehi 4567 6 patients patient NNS cord-335975-m6lkrehi 4567 7 ( ( -LRB- cord-335975-m6lkrehi 4567 8 79 79 CD cord-335975-m6lkrehi 4567 9 % % NN cord-335975-m6lkrehi 4567 10 ) ) -RRB- cord-335975-m6lkrehi 4567 11 and and CC cord-335975-m6lkrehi 4567 12 the the DT cord-335975-m6lkrehi 4567 13 second second JJ cord-335975-m6lkrehi 4567 14 comprised comprise VBN cord-335975-m6lkrehi 4567 15 78 78 CD cord-335975-m6lkrehi 4567 16 patients patient NNS cord-335975-m6lkrehi 4567 17 ( ( -LRB- cord-335975-m6lkrehi 4567 18 21 21 CD cord-335975-m6lkrehi 4567 19 % % NN cord-335975-m6lkrehi 4567 20 ) ) -RRB- cord-335975-m6lkrehi 4567 21 . . . cord-335975-m6lkrehi 4568 1 The the DT cord-335975-m6lkrehi 4568 2 two two CD cord-335975-m6lkrehi 4568 3 groups group NNS cord-335975-m6lkrehi 4568 4 did do VBD cord-335975-m6lkrehi 4568 5 not not RB cord-335975-m6lkrehi 4568 6 differ differ VB cord-335975-m6lkrehi 4568 7 significantly significantly RB cord-335975-m6lkrehi 4568 8 about about IN cord-335975-m6lkrehi 4568 9 sex sex NN cord-335975-m6lkrehi 4568 10 and and CC cord-335975-m6lkrehi 4568 11 age age NN cord-335975-m6lkrehi 4568 12 . . . cord-335975-m6lkrehi 4569 1 Hyperosmolar Hyperosmolar NNP cord-335975-m6lkrehi 4569 2 patients patient NNS cord-335975-m6lkrehi 4569 3 had have VBD cord-335975-m6lkrehi 4569 4 more more JJR cord-335975-m6lkrehi 4569 5 diabets diabet NNS cord-335975-m6lkrehi 4569 6 42.3 42.3 CD cord-335975-m6lkrehi 4569 7 % % NN cord-335975-m6lkrehi 4569 8 . . . cord-335975-m6lkrehi 4570 1 Patients patient NNS cord-335975-m6lkrehi 4570 2 in in IN cord-335975-m6lkrehi 4570 3 the the DT cord-335975-m6lkrehi 4570 4 two two CD cord-335975-m6lkrehi 4570 5 groups group NNS cord-335975-m6lkrehi 4570 6 did do VBD cord-335975-m6lkrehi 4570 7 not not RB cord-335975-m6lkrehi 4570 8 show show VB cord-335975-m6lkrehi 4570 9 significant significant JJ cord-335975-m6lkrehi 4570 10 differences difference NNS cord-335975-m6lkrehi 4570 11 in in IN cord-335975-m6lkrehi 4570 12 clinical clinical JJ cord-335975-m6lkrehi 4570 13 outcomes outcome NNS cord-335975-m6lkrehi 4570 14 , , , cord-335975-m6lkrehi 4570 15 including include VBG cord-335975-m6lkrehi 4570 16 APACHE APACHE NNP cord-335975-m6lkrehi 4570 17 II II NNP cord-335975-m6lkrehi 4570 18 and and CC cord-335975-m6lkrehi 4570 19 SAPS SAPS NNP cord-335975-m6lkrehi 4570 20 II II NNP cord-335975-m6lkrehi 4570 21 scores score NNS cord-335975-m6lkrehi 4570 22 . . . cord-335975-m6lkrehi 4571 1 Significant significant JJ cord-335975-m6lkrehi 4571 2 differences difference NNS cord-335975-m6lkrehi 4571 3 are be VBP cord-335975-m6lkrehi 4571 4 reported report VBN cord-335975-m6lkrehi 4571 5 between between IN cord-335975-m6lkrehi 4571 6 the the DT cord-335975-m6lkrehi 4571 7 two two CD cord-335975-m6lkrehi 4571 8 groups group NNS cord-335975-m6lkrehi 4571 9 , , , cord-335975-m6lkrehi 4571 10 in in IN cord-335975-m6lkrehi 4571 11 natremia natremia NN cord-335975-m6lkrehi 4571 12 , , , cord-335975-m6lkrehi 4571 13 creatinemia creatinemia NN cord-335975-m6lkrehi 4571 14 , , , cord-335975-m6lkrehi 4571 15 liver liver NN cord-335975-m6lkrehi 4571 16 transaminases transaminase NNS cord-335975-m6lkrehi 4571 17 . . . cord-335975-m6lkrehi 4572 1 The the DT cord-335975-m6lkrehi 4572 2 plasma plasma NN cord-335975-m6lkrehi 4572 3 osmolarity osmolarity NN cord-335975-m6lkrehi 4572 4 was be VBD cord-335975-m6lkrehi 4572 5 significantly significantly RB cord-335975-m6lkrehi 4572 6 different different JJ cord-335975-m6lkrehi 4572 7 between between IN cord-335975-m6lkrehi 4572 8 the the DT cord-335975-m6lkrehi 4572 9 two two CD cord-335975-m6lkrehi 4572 10 groups group NNS cord-335975-m6lkrehi 4572 11 with with IN cord-335975-m6lkrehi 4572 12 a a DT cord-335975-m6lkrehi 4572 13 mean mean NN cord-335975-m6lkrehi 4572 14 in in IN cord-335975-m6lkrehi 4572 15 the the DT cord-335975-m6lkrehi 4572 16 control control NN cord-335975-m6lkrehi 4572 17 group group NN cord-335975-m6lkrehi 4572 18 of of IN cord-335975-m6lkrehi 4572 19 269.77 269.77 CD cord-335975-m6lkrehi 4572 20 ± ± CD cord-335975-m6lkrehi 4572 21 12.73 12.73 CD cord-335975-m6lkrehi 4572 22 mol mol NN cord-335975-m6lkrehi 4572 23 L L NNP cord-335975-m6lkrehi 4572 24 while while IN cord-335975-m6lkrehi 4572 25 in in IN cord-335975-m6lkrehi 4572 26 the the DT cord-335975-m6lkrehi 4572 27 hyperosmolar hyperosmolar NNP cord-335975-m6lkrehi 4572 28 group group NN cord-335975-m6lkrehi 4572 29 it -PRON- PRP cord-335975-m6lkrehi 4572 30 was be VBD cord-335975-m6lkrehi 4572 31 346.95 346.95 CD cord-335975-m6lkrehi 4572 32 ± ± NNP cord-335975-m6lkrehi 4572 33 35.85 35.85 CD cord-335975-m6lkrehi 4572 34 mosmol mosmol NNP cord-335975-m6lkrehi 4572 35 L L NNP cord-335975-m6lkrehi 4572 36 ( ( -LRB- cord-335975-m6lkrehi 4572 37 p p NN cord-335975-m6lkrehi 4572 38 = = SYM cord-335975-m6lkrehi 4572 39 0.046 0.046 CD cord-335975-m6lkrehi 4572 40 ) ) -RRB- cord-335975-m6lkrehi 4572 41 . . . cord-335975-m6lkrehi 4573 1 The the DT cord-335975-m6lkrehi 4573 2 prevalence prevalence NN cord-335975-m6lkrehi 4573 3 of of IN cord-335975-m6lkrehi 4573 4 hyperosmolar hyperosmolar JJ cord-335975-m6lkrehi 4573 5 states state NNS cord-335975-m6lkrehi 4573 6 in in IN cord-335975-m6lkrehi 4573 7 the the DT cord-335975-m6lkrehi 4573 8 study study NN cord-335975-m6lkrehi 4573 9 was be VBD cord-335975-m6lkrehi 4573 10 21 21 CD cord-335975-m6lkrehi 4573 11 % % NN cord-335975-m6lkrehi 4573 12 with with IN cord-335975-m6lkrehi 4573 13 60 60 CD cord-335975-m6lkrehi 4573 14 % % NN cord-335975-m6lkrehi 4573 15 mortality mortality NN cord-335975-m6lkrehi 4573 16 . . . cord-335975-m6lkrehi 4574 1 In in IN cord-335975-m6lkrehi 4574 2 the the DT cord-335975-m6lkrehi 4574 3 control control NN cord-335975-m6lkrehi 4574 4 group group NN cord-335975-m6lkrehi 4574 5 41 41 CD cord-335975-m6lkrehi 4574 6 % % NN cord-335975-m6lkrehi 4574 7 were be VBD cord-335975-m6lkrehi 4574 8 intubated intubate VBN cord-335975-m6lkrehi 4574 9 - - HYPH cord-335975-m6lkrehi 4574 10 ventilated ventilate VBN cord-335975-m6lkrehi 4574 11 + + CC cord-335975-m6lkrehi 4574 12 21.2 21.2 CD cord-335975-m6lkrehi 4574 13 % % NN cord-335975-m6lkrehi 4574 14 received receive VBD cord-335975-m6lkrehi 4574 15 vasoactive vasoactive JJ cord-335975-m6lkrehi 4574 16 drugs drug NNS cord-335975-m6lkrehi 4574 17 and and CC cord-335975-m6lkrehi 4574 18 68.6 68.6 CD cord-335975-m6lkrehi 4574 19 % % NN cord-335975-m6lkrehi 4574 20 received receive VBD cord-335975-m6lkrehi 4574 21 antibiotic antibiotic JJ cord-335975-m6lkrehi 4574 22 therapy therapy NN cord-335975-m6lkrehi 4574 23 . . . cord-335975-m6lkrehi 4575 1 In in IN cord-335975-m6lkrehi 4575 2 the the DT cord-335975-m6lkrehi 4575 3 control control NN cord-335975-m6lkrehi 4575 4 group group NN cord-335975-m6lkrehi 4575 5 + + SYM cord-335975-m6lkrehi 4575 6 7%of 7%of CD cord-335975-m6lkrehi 4575 7 the the DT cord-335975-m6lkrehi 4575 8 patients patient NNS cord-335975-m6lkrehi 4575 9 were be VBD cord-335975-m6lkrehi 4575 10 complicated complicate VBN cord-335975-m6lkrehi 4575 11 by by IN cord-335975-m6lkrehi 4575 12 nosocomial nosocomial JJ cord-335975-m6lkrehi 4575 13 infection infection NN cord-335975-m6lkrehi 4575 14 , , , cord-335975-m6lkrehi 4575 15 9.9 9.9 CD cord-335975-m6lkrehi 4575 16 % % NN cord-335975-m6lkrehi 4575 17 by by IN cord-335975-m6lkrehi 4575 18 septic septic JJ cord-335975-m6lkrehi 4575 19 shock shock NN cord-335975-m6lkrehi 4575 20 and and CC cord-335975-m6lkrehi 4575 21 1 1 CD cord-335975-m6lkrehi 4575 22 % % NN cord-335975-m6lkrehi 4575 23 diseased disease VBN cord-335975-m6lkrehi 4575 24 by by IN cord-335975-m6lkrehi 4575 25 thromboembolic thromboembolic JJ cord-335975-m6lkrehi 4575 26 complications complication NNS cord-335975-m6lkrehi 4575 27 . . . cord-335975-m6lkrehi 4576 1 The the DT cord-335975-m6lkrehi 4576 2 deceased deceased JJ cord-335975-m6lkrehi 4576 3 subgroup subgroup NN cord-335975-m6lkrehi 4576 4 used use VBD cord-335975-m6lkrehi 4576 5 intubation intubation NN cord-335975-m6lkrehi 4576 6 artificial artificial JJ cord-335975-m6lkrehi 4576 7 ventilation ventilation NN cord-335975-m6lkrehi 4576 8 in in IN cord-335975-m6lkrehi 4576 9 89.36 89.36 CD cord-335975-m6lkrehi 4576 10 % % NN cord-335975-m6lkrehi 4576 11 , , , cord-335975-m6lkrehi 4576 12 vasoactive vasoactive JJ cord-335975-m6lkrehi 4576 13 drugs drug NNS cord-335975-m6lkrehi 4576 14 in in IN cord-335975-m6lkrehi 4576 15 68 68 CD cord-335975-m6lkrehi 4576 16 % % NN cord-335975-m6lkrehi 4576 17 , , , cord-335975-m6lkrehi 4576 18 and and CC cord-335975-m6lkrehi 4576 19 antibiotic antibiotic JJ cord-335975-m6lkrehi 4576 20 therapy therapy NN cord-335975-m6lkrehi 4576 21 in in IN cord-335975-m6lkrehi 4576 22 89.36 89.36 CD cord-335975-m6lkrehi 4576 23 % % NN cord-335975-m6lkrehi 4576 24 . . . cord-335975-m6lkrehi 4577 1 In in IN cord-335975-m6lkrehi 4577 2 the the DT cord-335975-m6lkrehi 4577 3 surviving survive VBG cord-335975-m6lkrehi 4577 4 subgroup subgroup NN cord-335975-m6lkrehi 4577 5 , , , cord-335975-m6lkrehi 4577 6 6.45 6.45 CD cord-335975-m6lkrehi 4577 7 % % NN cord-335975-m6lkrehi 4577 8 only only RB cord-335975-m6lkrehi 4577 9 contracted contract VBD cord-335975-m6lkrehi 4577 10 the the DT cord-335975-m6lkrehi 4577 11 nosocomial nosocomial JJ cord-335975-m6lkrehi 4577 12 infection infection NN cord-335975-m6lkrehi 4577 13 . . . cord-335975-m6lkrehi 4578 1 In in IN cord-335975-m6lkrehi 4578 2 the the DT cord-335975-m6lkrehi 4578 3 subgroup subgroup NN cord-335975-m6lkrehi 4578 4 died die VBD cord-335975-m6lkrehi 4578 5 51.1 51.1 CD cord-335975-m6lkrehi 4578 6 % % NN cord-335975-m6lkrehi 4578 7 are be VBP cord-335975-m6lkrehi 4578 8 of of IN cord-335975-m6lkrehi 4578 9 mixed mixed JJ cord-335975-m6lkrehi 4578 10 hyperosmolar hyperosmolar NNP cord-335975-m6lkrehi 4578 11 type type NN cord-335975-m6lkrehi 4578 12 + + SYM cord-335975-m6lkrehi 4578 13 82.4 82.4 CD cord-335975-m6lkrehi 4578 14 % % NN cord-335975-m6lkrehi 4578 15 hyperglycemic hyperglycemic JJ cord-335975-m6lkrehi 4578 16 hyperuremic hyperuremic NNP cord-335975-m6lkrehi 4578 17 + + SYM cord-335975-m6lkrehi 4578 18 55.6 55.6 CD cord-335975-m6lkrehi 4578 19 % % NN cord-335975-m6lkrehi 4578 20 hyperglycemic hyperglycemic JJ cord-335975-m6lkrehi 4578 21 hypernatremic hypernatremic JJ cord-335975-m6lkrehi 4578 22 type type NN cord-335975-m6lkrehi 4578 23 . . . cord-335975-m6lkrehi 4579 1 Conclusion conclusion NN cord-335975-m6lkrehi 4579 2 : : : cord-335975-m6lkrehi 4580 1 Hyperosmolar Hyperosmolar NNP cord-335975-m6lkrehi 4580 2 states state NNS cord-335975-m6lkrehi 4580 3 are be VBP cord-335975-m6lkrehi 4580 4 an an DT cord-335975-m6lkrehi 4580 5 independent independent JJ cord-335975-m6lkrehi 4580 6 a a DT cord-335975-m6lkrehi 4580 7 prognosis prognosis NN cord-335975-m6lkrehi 4580 8 factor factor NN cord-335975-m6lkrehi 4580 9 . . . cord-335975-m6lkrehi 4581 1 Intubation intubation NN cord-335975-m6lkrehi 4581 2 and and CC cord-335975-m6lkrehi 4581 3 ventilation ventilation NN cord-335975-m6lkrehi 4581 4 , , , cord-335975-m6lkrehi 4581 5 vasoactive vasoactive JJ cord-335975-m6lkrehi 4581 6 drugs drug NNS cord-335975-m6lkrehi 4581 7 and and CC cord-335975-m6lkrehi 4581 8 antibiotic antibiotic JJ cord-335975-m6lkrehi 4581 9 therapy therapy NN cord-335975-m6lkrehi 4581 10 increases increase NNS cord-335975-m6lkrehi 4581 11 considerably considerably RB cord-335975-m6lkrehi 4581 12 in in IN cord-335975-m6lkrehi 4581 13 hyperosmolar hyperosmolar NNP cord-335975-m6lkrehi 4581 14 states state NNS cord-335975-m6lkrehi 4581 15 . . . cord-335975-m6lkrehi 4582 1 Furthermore furthermore RB cord-335975-m6lkrehi 4582 2 , , , cord-335975-m6lkrehi 4582 3 it -PRON- PRP cord-335975-m6lkrehi 4582 4 induced induce VBD cord-335975-m6lkrehi 4582 5 serious serious JJ cord-335975-m6lkrehi 4582 6 complications complication NNS cord-335975-m6lkrehi 4582 7 as as IN cord-335975-m6lkrehi 4582 8 nosocomial nosocomial JJ cord-335975-m6lkrehi 4582 9 infections infection NNS cord-335975-m6lkrehi 4582 10 and and CC cord-335975-m6lkrehi 4582 11 septic septic JJ cord-335975-m6lkrehi 4582 12 shocks shock NNS cord-335975-m6lkrehi 4582 13 that that WDT cord-335975-m6lkrehi 4582 14 further further RB cord-335975-m6lkrehi 4582 15 aggravate aggravate VBP cord-335975-m6lkrehi 4582 16 the the DT cord-335975-m6lkrehi 4582 17 prognosis prognosis NN cord-335975-m6lkrehi 4582 18 even even RB cord-335975-m6lkrehi 4582 19 within within IN cord-335975-m6lkrehi 4582 20 hyperosmolar hyperosmolar NNP cord-335975-m6lkrehi 4582 21 states state NNS cord-335975-m6lkrehi 4582 22 . . . cord-335975-m6lkrehi 4583 1 Introduction introduction NN cord-335975-m6lkrehi 4583 2 : : : cord-335975-m6lkrehi 4584 1 Hyperthermia hyperthermia NN cord-335975-m6lkrehi 4584 2 represents represent VBZ cord-335975-m6lkrehi 4584 3 a a DT cord-335975-m6lkrehi 4584 4 major major JJ cord-335975-m6lkrehi 4584 5 life life NN cord-335975-m6lkrehi 4584 6 - - HYPH cord-335975-m6lkrehi 4584 7 threatening threaten VBG cord-335975-m6lkrehi 4584 8 medical medical JJ cord-335975-m6lkrehi 4584 9 emergency emergency NN cord-335975-m6lkrehi 4584 10 , , , cord-335975-m6lkrehi 4584 11 and and CC cord-335975-m6lkrehi 4584 12 is be VBZ cord-335975-m6lkrehi 4584 13 also also RB cord-335975-m6lkrehi 4584 14 one one CD cord-335975-m6lkrehi 4584 15 of of IN cord-335975-m6lkrehi 4584 16 the the DT cord-335975-m6lkrehi 4584 17 leading lead VBG cord-335975-m6lkrehi 4584 18 causes cause NNS cord-335975-m6lkrehi 4584 19 of of IN cord-335975-m6lkrehi 4584 20 death death NN cord-335975-m6lkrehi 4584 21 in in IN cord-335975-m6lkrehi 4584 22 young young JJ cord-335975-m6lkrehi 4584 23 athletes athlete NNS cord-335975-m6lkrehi 4584 24 worldwide worldwide RB cord-335975-m6lkrehi 4584 25 . . . cord-335975-m6lkrehi 4585 1 Its -PRON- PRP$ cord-335975-m6lkrehi 4585 2 incidence incidence NN cord-335975-m6lkrehi 4585 3 is be VBZ cord-335975-m6lkrehi 4585 4 rare rare JJ cord-335975-m6lkrehi 4585 5 and and CC cord-335975-m6lkrehi 4585 6 little little JJ cord-335975-m6lkrehi 4585 7 understood understand VBN cord-335975-m6lkrehi 4585 8 , , , cord-335975-m6lkrehi 4585 9 but but CC cord-335975-m6lkrehi 4585 10 its -PRON- PRP$ cord-335975-m6lkrehi 4585 11 mortality mortality NN cord-335975-m6lkrehi 4585 12 is be VBZ cord-335975-m6lkrehi 4585 13 on on IN cord-335975-m6lkrehi 4585 14 the the DT cord-335975-m6lkrehi 4585 15 rise rise NN cord-335975-m6lkrehi 4585 16 . . . cord-335975-m6lkrehi 4586 1 The the DT cord-335975-m6lkrehi 4586 2 objective objective NN cord-335975-m6lkrehi 4586 3 of of IN cord-335975-m6lkrehi 4586 4 this this DT cord-335975-m6lkrehi 4586 5 study study NN cord-335975-m6lkrehi 4586 6 was be VBD cord-335975-m6lkrehi 4586 7 to to TO cord-335975-m6lkrehi 4586 8 describe describe VB cord-335975-m6lkrehi 4586 9 the the DT cord-335975-m6lkrehi 4586 10 population population NN cord-335975-m6lkrehi 4586 11 of of IN cord-335975-m6lkrehi 4586 12 patients patient NNS cord-335975-m6lkrehi 4586 13 admitted admit VBN cord-335975-m6lkrehi 4586 14 for for IN cord-335975-m6lkrehi 4586 15 exertional exertional JJ cord-335975-m6lkrehi 4586 16 hyperthermia hyperthermia NN cord-335975-m6lkrehi 4586 17 in in IN cord-335975-m6lkrehi 4586 18 Martinique Martinique NNP cord-335975-m6lkrehi 4586 19 and and CC cord-335975-m6lkrehi 4586 20 Guadeloupe Guadeloupe NNP cord-335975-m6lkrehi 4586 21 and and CC cord-335975-m6lkrehi 4586 22 to to TO cord-335975-m6lkrehi 4586 23 determine determine VB cord-335975-m6lkrehi 4586 24 the the DT cord-335975-m6lkrehi 4586 25 prognostic prognostic JJ cord-335975-m6lkrehi 4586 26 factors factor NNS cord-335975-m6lkrehi 4586 27 . . . cord-335975-m6lkrehi 4587 1 Patients patient NNS cord-335975-m6lkrehi 4587 2 and and CC cord-335975-m6lkrehi 4587 3 methods method NNS cord-335975-m6lkrehi 4587 4 : : : cord-335975-m6lkrehi 4587 5 Retrospective retrospective JJ cord-335975-m6lkrehi 4587 6 and and CC cord-335975-m6lkrehi 4587 7 prospective prospective JJ cord-335975-m6lkrehi 4587 8 study study NN cord-335975-m6lkrehi 4587 9 , , , cord-335975-m6lkrehi 4587 10 including include VBG cord-335975-m6lkrehi 4587 11 all all DT cord-335975-m6lkrehi 4587 12 patients patient NNS cord-335975-m6lkrehi 4587 13 admitted admit VBN cord-335975-m6lkrehi 4587 14 for for IN cord-335975-m6lkrehi 4587 15 exertional exertional JJ cord-335975-m6lkrehi 4587 16 hyperthermia hyperthermia NN cord-335975-m6lkrehi 4587 17 in in IN cord-335975-m6lkrehi 4587 18 both both DT cord-335975-m6lkrehi 4587 19 emergency emergency NN cord-335975-m6lkrehi 4587 20 and and CC cord-335975-m6lkrehi 4587 21 resuscitation resuscitation NN cord-335975-m6lkrehi 4587 22 services service NNS cord-335975-m6lkrehi 4587 23 in in IN cord-335975-m6lkrehi 4587 24 Martinique Martinique NNP cord-335975-m6lkrehi 4587 25 and and CC cord-335975-m6lkrehi 4587 26 Guadeloupe Guadeloupe NNP cord-335975-m6lkrehi 4587 27 from from IN cord-335975-m6lkrehi 4587 28 January January NNP cord-335975-m6lkrehi 4587 29 2006 2006 CD cord-335975-m6lkrehi 4587 30 to to IN cord-335975-m6lkrehi 4587 31 June June NNP cord-335975-m6lkrehi 4587 32 2017 2017 CD cord-335975-m6lkrehi 4587 33 . . . cord-335975-m6lkrehi 4588 1 Results result NNS cord-335975-m6lkrehi 4588 2 were be VBD cord-335975-m6lkrehi 4588 3 expressed express VBN cord-335975-m6lkrehi 4588 4 as as IN cord-335975-m6lkrehi 4588 5 mean mean JJ cord-335975-m6lkrehi 4588 6 ± ± NNP cord-335975-m6lkrehi 4588 7 SD sd NN cord-335975-m6lkrehi 4588 8 or or CC cord-335975-m6lkrehi 4588 9 % % NN cord-335975-m6lkrehi 4588 10 . . . cord-335975-m6lkrehi 4589 1 Results result NNS cord-335975-m6lkrehi 4589 2 : : : cord-335975-m6lkrehi 4590 1 In in IN cord-335975-m6lkrehi 4590 2 10 10 CD cord-335975-m6lkrehi 4590 3 years year NNS cord-335975-m6lkrehi 4590 4 , , , cord-335975-m6lkrehi 4590 5 55 55 CD cord-335975-m6lkrehi 4590 6 patients patient NNS cord-335975-m6lkrehi 4590 7 were be VBD cord-335975-m6lkrehi 4590 8 observed observe VBN cord-335975-m6lkrehi 4590 9 ( ( -LRB- cord-335975-m6lkrehi 4590 10 age-79 age-79 NNP cord-335975-m6lkrehi 4590 11 ± ± NNP cord-335975-m6lkrehi 4590 12 18 18 CD cord-335975-m6lkrehi 4590 13 , , , cord-335975-m6lkrehi 4590 14 44 44 CD cord-335975-m6lkrehi 4590 15 men man NNS cord-335975-m6lkrehi 4590 16 and and CC cord-335975-m6lkrehi 4590 17 11 11 CD cord-335975-m6lkrehi 4590 18 women woman NNS cord-335975-m6lkrehi 4590 19 ) ) -RRB- cord-335975-m6lkrehi 4590 20 , , , cord-335975-m6lkrehi 4590 21 the the DT cord-335975-m6lkrehi 4590 22 main main JJ cord-335975-m6lkrehi 4590 23 antecedents antecedent NNS cord-335975-m6lkrehi 4590 24 of of IN cord-335975-m6lkrehi 4590 25 which which WDT cord-335975-m6lkrehi 4590 26 were-2 were-2 NNP cord-335975-m6lkrehi 4590 27 hypertension hypertension NN cord-335975-m6lkrehi 4590 28 , , , cord-335975-m6lkrehi 4590 29 2 2 CD cord-335975-m6lkrehi 4590 30 chronic chronic JJ cord-335975-m6lkrehi 4590 31 OH OH NNP cord-335975-m6lkrehi 4590 32 , , , cord-335975-m6lkrehi 4590 33 2 2 CD cord-335975-m6lkrehi 4590 34 psychoses psychosis NNS cord-335975-m6lkrehi 4590 35 , , , cord-335975-m6lkrehi 4590 36 1 1 CD cord-335975-m6lkrehi 4590 37 stress stress NN cord-335975-m6lkrehi 4590 38 hyperthermia hyperthermia NN cord-335975-m6lkrehi 4590 39 . . . cord-335975-m6lkrehi 4591 1 10 10 CD cord-335975-m6lkrehi 4591 2 ( ( -LRB- cord-335975-m6lkrehi 4591 3 18 18 CD cord-335975-m6lkrehi 4591 4 % % NN cord-335975-m6lkrehi 4591 5 ) ) -RRB- cord-335975-m6lkrehi 4591 6 of of IN cord-335975-m6lkrehi 4591 7 the the DT cord-335975-m6lkrehi 4591 8 patients patient NNS cord-335975-m6lkrehi 4591 9 had have VBD cord-335975-m6lkrehi 4591 10 seizures seizure NNS cord-335975-m6lkrehi 4591 11 initially initially RB cord-335975-m6lkrehi 4591 12 . . . cord-335975-m6lkrehi 4592 1 The the DT cord-335975-m6lkrehi 4592 2 pre pre JJ cord-335975-m6lkrehi 4592 3 - - JJ cord-335975-m6lkrehi 4592 4 hospital hospital JJ cord-335975-m6lkrehi 4592 5 management management NN cord-335975-m6lkrehi 4592 6 was be VBD cord-335975-m6lkrehi 4592 7 < < NNP cord-335975-m6lkrehi 4592 8 30 30 CD cord-335975-m6lkrehi 4592 9 min min NN cord-335975-m6lkrehi 4592 10 . . . cord-335975-m6lkrehi 4593 1 Nevertheless nevertheless RB cord-335975-m6lkrehi 4593 2 , , , cord-335975-m6lkrehi 4593 3 20 20 CD cord-335975-m6lkrehi 4593 4 ( ( -LRB- cord-335975-m6lkrehi 4593 5 36 36 CD cord-335975-m6lkrehi 4593 6 % % NN cord-335975-m6lkrehi 4593 7 ) ) -RRB- cord-335975-m6lkrehi 4593 8 patients patient NNS cord-335975-m6lkrehi 4593 9 were be VBD cord-335975-m6lkrehi 4593 10 admitted admit VBN cord-335975-m6lkrehi 4593 11 to to IN cord-335975-m6lkrehi 4593 12 ICU ICU NNP cord-335975-m6lkrehi 4593 13 due due IN cord-335975-m6lkrehi 4593 14 to to IN cord-335975-m6lkrehi 4593 15 organ organ NN cord-335975-m6lkrehi 4593 16 failure failure NN cord-335975-m6lkrehi 4593 17 ( ( -LRB- cord-335975-m6lkrehi 4593 18 neurologic neurologic JJ cord-335975-m6lkrehi 4593 19 74 74 CD cord-335975-m6lkrehi 4593 20 % % NN cord-335975-m6lkrehi 4593 21 , , , cord-335975-m6lkrehi 4593 22 hemodynamic hemodynamic JJ cord-335975-m6lkrehi 4593 23 2 2 CD cord-335975-m6lkrehi 4593 24 % % NN cord-335975-m6lkrehi 4593 25 , , , cord-335975-m6lkrehi 4593 26 liver liver NN cord-335975-m6lkrehi 4593 27 4 4 CD cord-335975-m6lkrehi 4593 28 % % NN cord-335975-m6lkrehi 4593 29 ) ) -RRB- cord-335975-m6lkrehi 4593 30 . . . cord-335975-m6lkrehi 4594 1 The the DT cord-335975-m6lkrehi 4594 2 progression progression NN cord-335975-m6lkrehi 4594 3 was be VBD cord-335975-m6lkrehi 4594 4 favorable favorable JJ cord-335975-m6lkrehi 4594 5 , , , cord-335975-m6lkrehi 4594 6 4 4 CD cord-335975-m6lkrehi 4594 7 deaths death NNS cord-335975-m6lkrehi 4594 8 , , , cord-335975-m6lkrehi 4594 9 including include VBG cord-335975-m6lkrehi 4594 10 3 3 CD cord-335975-m6lkrehi 4594 11 fulminant fulminant JJ cord-335975-m6lkrehi 4594 12 hepatitis hepatitis NN cord-335975-m6lkrehi 4594 13 and and CC cord-335975-m6lkrehi 4594 14 multi multi JJ cord-335975-m6lkrehi 4594 15 - - JJ cord-335975-m6lkrehi 4594 16 visceral visceral JJ cord-335975-m6lkrehi 4594 17 failure failure NN cord-335975-m6lkrehi 4594 18 . . . cord-335975-m6lkrehi 4595 1 The the DT cord-335975-m6lkrehi 4595 2 average average JJ cord-335975-m6lkrehi 4595 3 length length NN cord-335975-m6lkrehi 4595 4 of of IN cord-335975-m6lkrehi 4595 5 stay stay NN cord-335975-m6lkrehi 4595 6 in in IN cord-335975-m6lkrehi 4595 7 intensive intensive JJ cord-335975-m6lkrehi 4595 8 care care NN cord-335975-m6lkrehi 4595 9 units unit NNS cord-335975-m6lkrehi 4595 10 was be VBD cord-335975-m6lkrehi 4595 11 5 5 CD cord-335975-m6lkrehi 4595 12 days day NNS cord-335975-m6lkrehi 4595 13 ( ( -LRB- cord-335975-m6lkrehi 4595 14 ± ± NNP cord-335975-m6lkrehi 4595 15 6 6 CD cord-335975-m6lkrehi 4595 16 ) ) -RRB- cord-335975-m6lkrehi 4595 17 . . . cord-335975-m6lkrehi 4596 1 Conclusion conclusion NN cord-335975-m6lkrehi 4596 2 : : : cord-335975-m6lkrehi 4597 1 Despite despite IN cord-335975-m6lkrehi 4597 2 considerable considerable JJ cord-335975-m6lkrehi 4597 3 preventive preventive JJ cord-335975-m6lkrehi 4597 4 measures measure NNS cord-335975-m6lkrehi 4597 5 , , , cord-335975-m6lkrehi 4597 6 stress stress NN cord-335975-m6lkrehi 4597 7 hyperthermia hyperthermia NN cord-335975-m6lkrehi 4597 8 represents represent VBZ cord-335975-m6lkrehi 4597 9 a a DT cord-335975-m6lkrehi 4597 10 major major JJ cord-335975-m6lkrehi 4597 11 problem problem NN cord-335975-m6lkrehi 4597 12 within within IN cord-335975-m6lkrehi 4597 13 the the DT cord-335975-m6lkrehi 4597 14 military military NN cord-335975-m6lkrehi 4597 15 , , , cord-335975-m6lkrehi 4597 16 soldiers soldier NNS cord-335975-m6lkrehi 4597 17 and and CC cord-335975-m6lkrehi 4597 18 other other JJ cord-335975-m6lkrehi 4597 19 athletes athlete NNS cord-335975-m6lkrehi 4597 20 , , , cord-335975-m6lkrehi 4597 21 with with IN cord-335975-m6lkrehi 4597 22 a a DT cord-335975-m6lkrehi 4597 23 mortality mortality NN cord-335975-m6lkrehi 4597 24 rate rate NN cord-335975-m6lkrehi 4597 25 about about RB cord-335975-m6lkrehi 4597 26 10 10 CD cord-335975-m6lkrehi 4597 27 % % NN cord-335975-m6lkrehi 4597 28 in in IN cord-335975-m6lkrehi 4597 29 most most JJS cord-335975-m6lkrehi 4597 30 published publish VBN cord-335975-m6lkrehi 4597 31 series series NN cord-335975-m6lkrehi 4597 32 . . . cord-335975-m6lkrehi 4598 1 The the DT cord-335975-m6lkrehi 4598 2 most most RBS cord-335975-m6lkrehi 4598 3 effective effective JJ cord-335975-m6lkrehi 4598 4 method method NN cord-335975-m6lkrehi 4598 5 is be VBZ cord-335975-m6lkrehi 4598 6 immersion immersion NN cord-335975-m6lkrehi 4598 7 in in IN cord-335975-m6lkrehi 4598 8 ice ice NN cord-335975-m6lkrehi 4598 9 water water NN cord-335975-m6lkrehi 4598 10 . . . cord-335975-m6lkrehi 4599 1 There there EX cord-335975-m6lkrehi 4599 2 is be VBZ cord-335975-m6lkrehi 4599 3 an an DT cord-335975-m6lkrehi 4599 4 urgent urgent JJ cord-335975-m6lkrehi 4599 5 need need NN cord-335975-m6lkrehi 4599 6 to to TO cord-335975-m6lkrehi 4599 7 provide provide VB cord-335975-m6lkrehi 4599 8 the the DT cord-335975-m6lkrehi 4599 9 region region NN cord-335975-m6lkrehi 4599 10 with with IN cord-335975-m6lkrehi 4599 11 a a DT cord-335975-m6lkrehi 4599 12 clear clear JJ cord-335975-m6lkrehi 4599 13 preventive preventive JJ cord-335975-m6lkrehi 4599 14 policy policy NN cord-335975-m6lkrehi 4599 15 , , , cord-335975-m6lkrehi 4599 16 including include VBG cord-335975-m6lkrehi 4599 17 a a DT cord-335975-m6lkrehi 4599 18 relief relief NN cord-335975-m6lkrehi 4599 19 action action NN cord-335975-m6lkrehi 4599 20 plan plan NN cord-335975-m6lkrehi 4599 21 , , , cord-335975-m6lkrehi 4599 22 training train VBG cord-335975-m6lkrehi 4599 23 for for IN cord-335975-m6lkrehi 4599 24 doctors doctor NNS cord-335975-m6lkrehi 4599 25 , , , cord-335975-m6lkrehi 4599 26 athletes athlete NNS cord-335975-m6lkrehi 4599 27 and and CC cord-335975-m6lkrehi 4599 28 other other JJ cord-335975-m6lkrehi 4599 29 health health NN cord-335975-m6lkrehi 4599 30 professionals professional NNS cord-335975-m6lkrehi 4599 31 at at IN cord-335975-m6lkrehi 4599 32 risk risk NN cord-335975-m6lkrehi 4599 33 of of IN cord-335975-m6lkrehi 4599 34 hyperthermia hyperthermia NN cord-335975-m6lkrehi 4599 35 . . . cord-335975-m6lkrehi 4600 1 Chapoutot Chapoutot NNP cord-335975-m6lkrehi 4600 2 Anne Anne NNP cord-335975-m6lkrehi 4600 3 - - HYPH cord-335975-m6lkrehi 4600 4 Gaëlle Gaëlle NNP cord-335975-m6lkrehi 4600 5 1 1 CD cord-335975-m6lkrehi 4600 6 , , , cord-335975-m6lkrehi 4600 7 Leteurtre Leteurtre NNP cord-335975-m6lkrehi 4600 8 Stéphane Stéphane NNP cord-335975-m6lkrehi 4600 9 1 1 CD cord-335975-m6lkrehi 4600 10 , , , cord-335975-m6lkrehi 4600 11 Chamouine Chamouine NNP cord-335975-m6lkrehi 4600 12 Abdourahim Abdourahim NNP cord-335975-m6lkrehi 4600 13 2 2 CD cord-335975-m6lkrehi 4600 14 ( ( -LRB- cord-335975-m6lkrehi 4600 15 2008 2008 CD cord-335975-m6lkrehi 4600 16 ) ) -RRB- cord-335975-m6lkrehi 4600 17 . . . cord-335975-m6lkrehi 4601 1 The the DT cord-335975-m6lkrehi 4601 2 University University NNP cord-335975-m6lkrehi 4601 3 Hospital Hospital NNP cord-335975-m6lkrehi 4601 4 of of IN cord-335975-m6lkrehi 4601 5 Lille Lille NNP cord-335975-m6lkrehi 4601 6 is be VBZ cord-335975-m6lkrehi 4601 7 a a DT cord-335975-m6lkrehi 4601 8 pediatric pediatric JJ cord-335975-m6lkrehi 4601 9 center center NN cord-335975-m6lkrehi 4601 10 including include VBG cord-335975-m6lkrehi 4601 11 several several JJ cord-335975-m6lkrehi 4601 12 IteCUs IteCUs NNP cord-335975-m6lkrehi 4601 13 in in IN cord-335975-m6lkrehi 4601 14 its -PRON- PRP$ cord-335975-m6lkrehi 4601 15 pediatric pediatric JJ cord-335975-m6lkrehi 4601 16 hematology hematology NN cord-335975-m6lkrehi 4601 17 or or CC cord-335975-m6lkrehi 4601 18 gastrology gastrology NN cord-335975-m6lkrehi 4601 19 departments department NNS cord-335975-m6lkrehi 4601 20 , , , cord-335975-m6lkrehi 4601 21 and and CC cord-335975-m6lkrehi 4601 22 more more RBR cord-335975-m6lkrehi 4601 23 recently recently RB cord-335975-m6lkrehi 4601 24 in in IN cord-335975-m6lkrehi 4601 25 its -PRON- PRP$ cord-335975-m6lkrehi 4601 26 pediatric pediatric JJ cord-335975-m6lkrehi 4601 27 surgical surgical JJ cord-335975-m6lkrehi 4601 28 department department NN cord-335975-m6lkrehi 4601 29 . . . cord-335975-m6lkrehi 4602 1 Moreover moreover RB cord-335975-m6lkrehi 4602 2 , , , cord-335975-m6lkrehi 4602 3 there there EX cord-335975-m6lkrehi 4602 4 are be VBP cord-335975-m6lkrehi 4602 5 4 4 CD cord-335975-m6lkrehi 4602 6 - - SYM cord-335975-m6lkrehi 4602 7 6 6 CD cord-335975-m6lkrehi 4602 8 IteCU IteCU NNP cord-335975-m6lkrehi 4602 9 extra extra JJ cord-335975-m6lkrehi 4602 10 - - NNS cord-335975-m6lkrehi 4602 11 beds bed NNS cord-335975-m6lkrehi 4602 12 within within IN cord-335975-m6lkrehi 4602 13 the the DT cord-335975-m6lkrehi 4602 14 12 12 CD cord-335975-m6lkrehi 4602 15 - - SYM cord-335975-m6lkrehi 4602 16 14 14 CD cord-335975-m6lkrehi 4602 17 bed bed NN cord-335975-m6lkrehi 4602 18 pediatric pediatric JJ cord-335975-m6lkrehi 4602 19 intensive intensive JJ cord-335975-m6lkrehi 4602 20 care care NN cord-335975-m6lkrehi 4602 21 unit unit NN cord-335975-m6lkrehi 4602 22 ( ( -LRB- cord-335975-m6lkrehi 4602 23 IveCU IveCU NNP cord-335975-m6lkrehi 4602 24 ) ) -RRB- cord-335975-m6lkrehi 4602 25 . . . cord-335975-m6lkrehi 4603 1 The the DT cord-335975-m6lkrehi 4603 2 Hospital Hospital NNP cord-335975-m6lkrehi 4603 3 of of IN cord-335975-m6lkrehi 4603 4 Mayotte Mayotte NNP cord-335975-m6lkrehi 4603 5 has have VBZ cord-335975-m6lkrehi 4603 6 no no DT cord-335975-m6lkrehi 4603 7 pediatric pediatric JJ cord-335975-m6lkrehi 4603 8 IveCU IveCU NNP cord-335975-m6lkrehi 4603 9 but but CC cord-335975-m6lkrehi 4603 10 a a DT cord-335975-m6lkrehi 4603 11 polyvalent polyvalent JJ cord-335975-m6lkrehi 4603 12 one one NN cord-335975-m6lkrehi 4603 13 for for IN cord-335975-m6lkrehi 4603 14 adults adult NNS cord-335975-m6lkrehi 4603 15 , , , cord-335975-m6lkrehi 4603 16 which which WDT cord-335975-m6lkrehi 4603 17 receives receive VBZ cord-335975-m6lkrehi 4603 18 children child NNS cord-335975-m6lkrehi 4603 19 when when WRB cord-335975-m6lkrehi 4603 20 necessary necessary JJ cord-335975-m6lkrehi 4603 21 , , , cord-335975-m6lkrehi 4603 22 as as RB cord-335975-m6lkrehi 4603 23 well well RB cord-335975-m6lkrehi 4603 24 as as IN cord-335975-m6lkrehi 4603 25 a a DT cord-335975-m6lkrehi 4603 26 4 4 CD cord-335975-m6lkrehi 4603 27 bed bed NN cord-335975-m6lkrehi 4603 28 IteCU itecu NN cord-335975-m6lkrehi 4603 29 . . . cord-335975-m6lkrehi 4604 1 The the DT cord-335975-m6lkrehi 4604 2 aim aim NN cord-335975-m6lkrehi 4604 3 of of IN cord-335975-m6lkrehi 4604 4 this this DT cord-335975-m6lkrehi 4604 5 study study NN cord-335975-m6lkrehi 4604 6 was be VBD cord-335975-m6lkrehi 4604 7 to to TO cord-335975-m6lkrehi 4604 8 describe describe VB cord-335975-m6lkrehi 4604 9 prospectively prospectively RB cord-335975-m6lkrehi 4604 10 the the DT cord-335975-m6lkrehi 4604 11 pediatric pediatric JJ cord-335975-m6lkrehi 4604 12 population population NN cord-335975-m6lkrehi 4604 13 which which WDT cord-335975-m6lkrehi 4604 14 was be VBD cord-335975-m6lkrehi 4604 15 admitted admit VBN cord-335975-m6lkrehi 4604 16 in in IN cord-335975-m6lkrehi 4604 17 the the DT cord-335975-m6lkrehi 4604 18 IteCUs IteCUs NNP cord-335975-m6lkrehi 4604 19 of of IN cord-335975-m6lkrehi 4604 20 Lille Lille NNP cord-335975-m6lkrehi 4604 21 and and CC cord-335975-m6lkrehi 4604 22 Mayotte Mayotte NNP cord-335975-m6lkrehi 4604 23 over over IN cord-335975-m6lkrehi 4604 24 a a DT cord-335975-m6lkrehi 4604 25 one one CD cord-335975-m6lkrehi 4604 26 - - HYPH cord-335975-m6lkrehi 4604 27 year year NN cord-335975-m6lkrehi 4604 28 period period NN cord-335975-m6lkrehi 4604 29 from from IN cord-335975-m6lkrehi 4604 30 June June NNP cord-335975-m6lkrehi 4604 31 2016 2016 CD cord-335975-m6lkrehi 4604 32 to to IN cord-335975-m6lkrehi 4604 33 May May NNP cord-335975-m6lkrehi 4604 34 2017 2017 CD cord-335975-m6lkrehi 4604 35 . . . cord-335975-m6lkrehi 4605 1 Patients patient NNS cord-335975-m6lkrehi 4605 2 and and CC cord-335975-m6lkrehi 4605 3 methods method NNS cord-335975-m6lkrehi 4605 4 : : : cord-335975-m6lkrehi 4605 5 In in IN cord-335975-m6lkrehi 4605 6 this this DT cord-335975-m6lkrehi 4605 7 twin twin JJ cord-335975-m6lkrehi 4605 8 - - HYPH cord-335975-m6lkrehi 4605 9 center center NN cord-335975-m6lkrehi 4605 10 , , , cord-335975-m6lkrehi 4605 11 prospective prospective JJ cord-335975-m6lkrehi 4605 12 and and CC cord-335975-m6lkrehi 4605 13 observational observational JJ cord-335975-m6lkrehi 4605 14 study study NN cord-335975-m6lkrehi 4605 15 , , , cord-335975-m6lkrehi 4605 16 data datum NNS cord-335975-m6lkrehi 4605 17 were be VBD cord-335975-m6lkrehi 4605 18 collected collect VBN cord-335975-m6lkrehi 4605 19 for for IN cord-335975-m6lkrehi 4605 20 each each DT cord-335975-m6lkrehi 4605 21 patient patient NN cord-335975-m6lkrehi 4605 22 admitted admit VBN cord-335975-m6lkrehi 4605 23 during during IN cord-335975-m6lkrehi 4605 24 the the DT cord-335975-m6lkrehi 4605 25 test test NN cord-335975-m6lkrehi 4605 26 period period NN cord-335975-m6lkrehi 4605 27 in in IN cord-335975-m6lkrehi 4605 28 IteCUs IteCUs NNP cord-335975-m6lkrehi 4605 29 of of IN cord-335975-m6lkrehi 4605 30 both both CC cord-335975-m6lkrehi 4605 31 Lille Lille NNP cord-335975-m6lkrehi 4605 32 and and CC cord-335975-m6lkrehi 4605 33 Mayotte Mayotte NNP cord-335975-m6lkrehi 4605 34 pediatric pediatric JJ cord-335975-m6lkrehi 4605 35 hospitalsgeneral hospitalsgeneral JJ cord-335975-m6lkrehi 4605 36 information information NN cord-335975-m6lkrehi 4605 37 about about IN cord-335975-m6lkrehi 4605 38 the the DT cord-335975-m6lkrehi 4605 39 patient patient NN cord-335975-m6lkrehi 4605 40 , , , cord-335975-m6lkrehi 4605 41 characteristics characteristic NNS cord-335975-m6lkrehi 4605 42 of of IN cord-335975-m6lkrehi 4605 43 each each DT cord-335975-m6lkrehi 4605 44 stay stay NN cord-335975-m6lkrehi 4605 45 , , , cord-335975-m6lkrehi 4605 46 severity severity NN cord-335975-m6lkrehi 4605 47 scores score NNS cord-335975-m6lkrehi 4605 48 on on IN cord-335975-m6lkrehi 4605 49 admission admission NN cord-335975-m6lkrehi 4605 50 , , , cord-335975-m6lkrehi 4605 51 type type NN cord-335975-m6lkrehi 4605 52 of of IN cord-335975-m6lkrehi 4605 53 treatments treatment NNS cord-335975-m6lkrehi 4605 54 implemented implement VBN cord-335975-m6lkrehi 4605 55 , , , cord-335975-m6lkrehi 4605 56 the the DT cord-335975-m6lkrehi 4605 57 report report NN cord-335975-m6lkrehi 4605 58 of of IN cord-335975-m6lkrehi 4605 59 the the DT cord-335975-m6lkrehi 4605 60 stay stay NN cord-335975-m6lkrehi 4605 61 and and CC cord-335975-m6lkrehi 4605 62 patient patient NN cord-335975-m6lkrehi 4605 63 's 's POS cord-335975-m6lkrehi 4605 64 evolution evolution NN cord-335975-m6lkrehi 4605 65 . . . cord-335975-m6lkrehi 4606 1 A a DT cord-335975-m6lkrehi 4606 2 standard standard JJ cord-335975-m6lkrehi 4606 3 declaration declaration NN cord-335975-m6lkrehi 4606 4 was be VBD cord-335975-m6lkrehi 4606 5 made make VBN cord-335975-m6lkrehi 4606 6 with with IN cord-335975-m6lkrehi 4606 7 an an DT cord-335975-m6lkrehi 4606 8 authorization authorization NN cord-335975-m6lkrehi 4606 9 granted grant VBN cord-335975-m6lkrehi 4606 10 by by IN cord-335975-m6lkrehi 4606 11 the the DT cord-335975-m6lkrehi 4606 12 local local JJ cord-335975-m6lkrehi 4606 13 Commission Commission NNP cord-335975-m6lkrehi 4606 14 on on IN cord-335975-m6lkrehi 4606 15 Informatics Informatics NNP cord-335975-m6lkrehi 4606 16 and and CC cord-335975-m6lkrehi 4606 17 Liberty Liberty NNP cord-335975-m6lkrehi 4606 18 ( ( -LRB- cord-335975-m6lkrehi 4606 19 French French NNP cord-335975-m6lkrehi 4606 20 Commission Commission NNP cord-335975-m6lkrehi 4606 21 Informatique Informatique NNP cord-335975-m6lkrehi 4606 22 et et FW cord-335975-m6lkrehi 4606 23 Liberté Liberté NNP cord-335975-m6lkrehi 4606 24 , , , cord-335975-m6lkrehi 4606 25 CIL CIL NNP cord-335975-m6lkrehi 4606 26 ) ) -RRB- cord-335975-m6lkrehi 4606 27 . . . cord-335975-m6lkrehi 4607 1 Results result NNS cord-335975-m6lkrehi 4607 2 : : : cord-335975-m6lkrehi 4608 1 During during IN cord-335975-m6lkrehi 4608 2 the the DT cord-335975-m6lkrehi 4608 3 course course NN cord-335975-m6lkrehi 4608 4 of of IN cord-335975-m6lkrehi 4608 5 the the DT cord-335975-m6lkrehi 4608 6 study study NN cord-335975-m6lkrehi 4608 7 , , , cord-335975-m6lkrehi 4608 8 about about RB cord-335975-m6lkrehi 4608 9 450 450 CD cord-335975-m6lkrehi 4608 10 children child NNS cord-335975-m6lkrehi 4608 11 were be VBD cord-335975-m6lkrehi 4608 12 admitted admit VBN cord-335975-m6lkrehi 4608 13 in in IN cord-335975-m6lkrehi 4608 14 each each DT cord-335975-m6lkrehi 4608 15 center center NN cord-335975-m6lkrehi 4608 16 . . . cord-335975-m6lkrehi 4609 1 The the DT cord-335975-m6lkrehi 4609 2 collected collect VBN cord-335975-m6lkrehi 4609 3 data datum NNS cord-335975-m6lkrehi 4609 4 allow allow VBP cord-335975-m6lkrehi 4609 5 to to TO cord-335975-m6lkrehi 4609 6 describe describe VB cord-335975-m6lkrehi 4609 7 and and CC cord-335975-m6lkrehi 4609 8 compare compare VB cord-335975-m6lkrehi 4609 9 both both DT cord-335975-m6lkrehi 4609 10 populations population NNS cord-335975-m6lkrehi 4609 11 in in IN cord-335975-m6lkrehi 4609 12 terms term NNS cord-335975-m6lkrehi 4609 13 of of IN cord-335975-m6lkrehi 4609 14 severity severity NN cord-335975-m6lkrehi 4609 15 of of IN cord-335975-m6lkrehi 4609 16 each each DT cord-335975-m6lkrehi 4609 17 patient patient NN cord-335975-m6lkrehi 4609 18 's 's POS cord-335975-m6lkrehi 4609 19 condition condition NN cord-335975-m6lkrehi 4609 20 . . . cord-335975-m6lkrehi 4610 1 This this DT cord-335975-m6lkrehi 4610 2 study study NN cord-335975-m6lkrehi 4610 3 based base VBN cord-335975-m6lkrehi 4610 4 on on IN cord-335975-m6lkrehi 4610 5 a a DT cord-335975-m6lkrehi 4610 6 very very RB cord-335975-m6lkrehi 4610 7 large large JJ cord-335975-m6lkrehi 4610 8 cohort cohort NN cord-335975-m6lkrehi 4610 9 has have VBZ cord-335975-m6lkrehi 4610 10 permitted permit VBN cord-335975-m6lkrehi 4610 11 to to TO cord-335975-m6lkrehi 4610 12 compare compare VB cord-335975-m6lkrehi 4610 13 the the DT cord-335975-m6lkrehi 4610 14 population population NN cord-335975-m6lkrehi 4610 15 of of IN cord-335975-m6lkrehi 4610 16 a a DT cord-335975-m6lkrehi 4610 17 regional regional JJ cord-335975-m6lkrehi 4610 18 hospital hospital NN cord-335975-m6lkrehi 4610 19 with with IN cord-335975-m6lkrehi 4610 20 that that DT cord-335975-m6lkrehi 4610 21 of of IN cord-335975-m6lkrehi 4610 22 a a DT cord-335975-m6lkrehi 4610 23 university university NN cord-335975-m6lkrehi 4610 24 hospital hospital NN cord-335975-m6lkrehi 4610 25 and and CC cord-335975-m6lkrehi 4610 26 to to TO cord-335975-m6lkrehi 4610 27 demonstrate demonstrate VB cord-335975-m6lkrehi 4610 28 that that IN cord-335975-m6lkrehi 4610 29 a a DT cord-335975-m6lkrehi 4610 30 health health NN cord-335975-m6lkrehi 4610 31 - - HYPH cord-335975-m6lkrehi 4610 32 care care NN cord-335975-m6lkrehi 4610 33 provision provision NN cord-335975-m6lkrehi 4610 34 including include VBG cord-335975-m6lkrehi 4610 35 a a DT cord-335975-m6lkrehi 4610 36 pediatric pediatric JJ cord-335975-m6lkrehi 4610 37 intensive intensive JJ cord-335975-m6lkrehi 4610 38 care care NN cord-335975-m6lkrehi 4610 39 unit unit NN cord-335975-m6lkrehi 4610 40 is be VBZ cord-335975-m6lkrehi 4610 41 needed need VBN cord-335975-m6lkrehi 4610 42 on on IN cord-335975-m6lkrehi 4610 43 Mayotte Mayotte NNP cord-335975-m6lkrehi 4610 44 Island Island NNP cord-335975-m6lkrehi 4610 45 . . . cord-335975-m6lkrehi 4611 1 Introduction introduction NN cord-335975-m6lkrehi 4611 2 : : : cord-335975-m6lkrehi 4612 1 Simulation simulation NN cord-335975-m6lkrehi 4612 2 in in IN cord-335975-m6lkrehi 4612 3 intensive intensive JJ cord-335975-m6lkrehi 4612 4 care care NN cord-335975-m6lkrehi 4612 5 is be VBZ cord-335975-m6lkrehi 4612 6 an an DT cord-335975-m6lkrehi 4612 7 innovative innovative JJ cord-335975-m6lkrehi 4612 8 method method NN cord-335975-m6lkrehi 4612 9 for for IN cord-335975-m6lkrehi 4612 10 teaching teaching NN cord-335975-m6lkrehi 4612 11 . . . cord-335975-m6lkrehi 4613 1 Respiratory respiratory JJ cord-335975-m6lkrehi 4613 2 settings setting NNS cord-335975-m6lkrehi 4613 3 are be VBP cord-335975-m6lkrehi 4613 4 responsible responsible JJ cord-335975-m6lkrehi 4613 5 for for IN cord-335975-m6lkrehi 4613 6 some some DT cord-335975-m6lkrehi 4613 7 morbi morbi NN cord-335975-m6lkrehi 4613 8 - - HYPH cord-335975-m6lkrehi 4613 9 mortality mortality NN cord-335975-m6lkrehi 4613 10 of of IN cord-335975-m6lkrehi 4613 11 our -PRON- PRP$ cord-335975-m6lkrehi 4613 12 patients patient NNS cord-335975-m6lkrehi 4613 13 . . . cord-335975-m6lkrehi 4614 1 For for IN cord-335975-m6lkrehi 4614 2 this this DT cord-335975-m6lkrehi 4614 3 reason reason NN cord-335975-m6lkrehi 4614 4 we -PRON- PRP cord-335975-m6lkrehi 4614 5 develop develop VBP cord-335975-m6lkrehi 4614 6 a a DT cord-335975-m6lkrehi 4614 7 simulator simulator NN cord-335975-m6lkrehi 4614 8 of of IN cord-335975-m6lkrehi 4614 9 artificial artificial JJ cord-335975-m6lkrehi 4614 10 ventilation ventilation NN cord-335975-m6lkrehi 4614 11 ( ( -LRB- cord-335975-m6lkrehi 4614 12 SimVA SimVA NNP cord-335975-m6lkrehi 4614 13 ) ) -RRB- cord-335975-m6lkrehi 4614 14 and and CC cord-335975-m6lkrehi 4614 15 virtual virtual JJ cord-335975-m6lkrehi 4614 16 patients patient NNS cord-335975-m6lkrehi 4614 17 . . . cord-335975-m6lkrehi 4615 1 Mathematical mathematical JJ cord-335975-m6lkrehi 4615 2 model model NN cord-335975-m6lkrehi 4615 3 resolved resolve VBD cord-335975-m6lkrehi 4615 4 differential differential JJ cord-335975-m6lkrehi 4615 5 equations equation NNS cord-335975-m6lkrehi 4615 6 of of IN cord-335975-m6lkrehi 4615 7 chest chest NN cord-335975-m6lkrehi 4615 8 and and CC cord-335975-m6lkrehi 4615 9 lung lung NN cord-335975-m6lkrehi 4615 10 movements movement NNS cord-335975-m6lkrehi 4615 11 in in IN cord-335975-m6lkrehi 4615 12 order order NN cord-335975-m6lkrehi 4615 13 to to TO cord-335975-m6lkrehi 4615 14 match match VB cord-335975-m6lkrehi 4615 15 with with IN cord-335975-m6lkrehi 4615 16 a a DT cord-335975-m6lkrehi 4615 17 clinical clinical JJ cord-335975-m6lkrehi 4615 18 data data NN cord-335975-m6lkrehi 4615 19 base base NN cord-335975-m6lkrehi 4615 20 . . . cord-335975-m6lkrehi 4616 1 The the DT cord-335975-m6lkrehi 4616 2 goal goal NN cord-335975-m6lkrehi 4616 3 of of IN cord-335975-m6lkrehi 4616 4 this this DT cord-335975-m6lkrehi 4616 5 study study NN cord-335975-m6lkrehi 4616 6 was be VBD cord-335975-m6lkrehi 4616 7 to to TO cord-335975-m6lkrehi 4616 8 evaluate evaluate VB cord-335975-m6lkrehi 4616 9 and and CC cord-335975-m6lkrehi 4616 10 compare compare VB cord-335975-m6lkrehi 4616 11 virtual virtual JJ cord-335975-m6lkrehi 4616 12 patients patient NNS cord-335975-m6lkrehi 4616 13 respiratory respiratory JJ cord-335975-m6lkrehi 4616 14 mechanic mechanic NN cord-335975-m6lkrehi 4616 15 with with IN cord-335975-m6lkrehi 4616 16 the the DT cord-335975-m6lkrehi 4616 17 results result NNS cord-335975-m6lkrehi 4616 18 of of IN cord-335975-m6lkrehi 4616 19 4 4 CD cord-335975-m6lkrehi 4616 20 different different JJ cord-335975-m6lkrehi 4616 21 protocols protocol NNS cord-335975-m6lkrehi 4616 22 of of IN cord-335975-m6lkrehi 4616 23 ventilation ventilation NN cord-335975-m6lkrehi 4616 24 from from IN cord-335975-m6lkrehi 4616 25 2 2 CD cord-335975-m6lkrehi 4616 26 large large JJ cord-335975-m6lkrehi 4616 27 randomised randomised JJ cord-335975-m6lkrehi 4616 28 controlled control VBN cord-335975-m6lkrehi 4616 29 trial trial NN cord-335975-m6lkrehi 4616 30 - - : cord-335975-m6lkrehi 4616 31 Arma Arma NNP cord-335975-m6lkrehi 4616 32 ( ( -LRB- cord-335975-m6lkrehi 4616 33 1 1 CD cord-335975-m6lkrehi 4616 34 ) ) -RRB- cord-335975-m6lkrehi 4616 35 and and CC cord-335975-m6lkrehi 4616 36 Express Express NNP cord-335975-m6lkrehi 4616 37 ( ( -LRB- cord-335975-m6lkrehi 4616 38 2 2 CD cord-335975-m6lkrehi 4616 39 ) ) -RRB- cord-335975-m6lkrehi 4616 40 . . . cord-335975-m6lkrehi 4617 1 Patients patient NNS cord-335975-m6lkrehi 4617 2 and and CC cord-335975-m6lkrehi 4617 3 methods method NNS cord-335975-m6lkrehi 4617 4 : : : cord-335975-m6lkrehi 4617 5 Virtual virtual JJ cord-335975-m6lkrehi 4617 6 patients patient NNS cord-335975-m6lkrehi 4617 7 had have VBD cord-335975-m6lkrehi 4617 8 ARDS ARDS NNP cord-335975-m6lkrehi 4617 9 , , , cord-335975-m6lkrehi 4617 10 and and CC cord-335975-m6lkrehi 4617 11 were be VBD cord-335975-m6lkrehi 4617 12 defined define VBN cord-335975-m6lkrehi 4617 13 by by IN cord-335975-m6lkrehi 4617 14 different different JJ cord-335975-m6lkrehi 4617 15 thoracic thoracic JJ cord-335975-m6lkrehi 4617 16 and and CC cord-335975-m6lkrehi 4617 17 pulmonar pulmonar JJ cord-335975-m6lkrehi 4617 18 compliance compliance NN cord-335975-m6lkrehi 4617 19 , , , cord-335975-m6lkrehi 4617 20 total total JJ cord-335975-m6lkrehi 4617 21 resistance resistance NN cord-335975-m6lkrehi 4617 22 , , , cord-335975-m6lkrehi 4617 23 lung lung NN cord-335975-m6lkrehi 4617 24 volumes volume NNS cord-335975-m6lkrehi 4617 25 , , , cord-335975-m6lkrehi 4617 26 pressure pressure NN cord-335975-m6lkrehi 4617 27 - - HYPH cord-335975-m6lkrehi 4617 28 volume volume NN cord-335975-m6lkrehi 4617 29 relation relation NN cord-335975-m6lkrehi 4617 30 , , , cord-335975-m6lkrehi 4617 31 and and CC cord-335975-m6lkrehi 4617 32 pressure pressure NN cord-335975-m6lkrehi 4617 33 and and CC cord-335975-m6lkrehi 4617 34 volume volume NN cord-335975-m6lkrehi 4617 35 recruitment recruitment NN cord-335975-m6lkrehi 4617 36 coefficients coefficient NNS cord-335975-m6lkrehi 4617 37 . . . cord-335975-m6lkrehi 4618 1 Ventilatory ventilatory JJ cord-335975-m6lkrehi 4618 2 protocols protocol NNS cord-335975-m6lkrehi 4618 3 were be VBD cord-335975-m6lkrehi 4618 4 High high JJ cord-335975-m6lkrehi 4618 5 versus versus IN cord-335975-m6lkrehi 4618 6 Low low JJ cord-335975-m6lkrehi 4618 7 VT VT NNP cord-335975-m6lkrehi 4618 8 ( ( -LRB- cord-335975-m6lkrehi 4618 9 Arma Arma NNP cord-335975-m6lkrehi 4618 10 study study NN cord-335975-m6lkrehi 4618 11 ) ) -RRB- cord-335975-m6lkrehi 4618 12 and and CC cord-335975-m6lkrehi 4618 13 Max Max NNP cord-335975-m6lkrehi 4618 14 versus versus IN cord-335975-m6lkrehi 4618 15 Min Min NNP cord-335975-m6lkrehi 4618 16 distension distension NN cord-335975-m6lkrehi 4618 17 according accord VBG cord-335975-m6lkrehi 4618 18 to to IN cord-335975-m6lkrehi 4618 19 PEP pep NN cord-335975-m6lkrehi 4618 20 ( ( -LRB- cord-335975-m6lkrehi 4618 21 Express Express NNP cord-335975-m6lkrehi 4618 22 study study NN cord-335975-m6lkrehi 4618 23 ) ) -RRB- cord-335975-m6lkrehi 4618 24 . . . cord-335975-m6lkrehi 4619 1 Each each DT cord-335975-m6lkrehi 4619 2 virtual virtual JJ cord-335975-m6lkrehi 4619 3 patient patient NN cord-335975-m6lkrehi 4619 4 was be VBD cord-335975-m6lkrehi 4619 5 titrated titrate VBN cord-335975-m6lkrehi 4619 6 on on IN cord-335975-m6lkrehi 4619 7 the the DT cord-335975-m6lkrehi 4619 8 simulator simulator NN cord-335975-m6lkrehi 4619 9 with with IN cord-335975-m6lkrehi 4619 10 the the DT cord-335975-m6lkrehi 4619 11 4 4 CD cord-335975-m6lkrehi 4619 12 protocols protocol NNS cord-335975-m6lkrehi 4619 13 . . . cord-335975-m6lkrehi 4620 1 Respiratory respiratory JJ cord-335975-m6lkrehi 4620 2 frequency frequency NN cord-335975-m6lkrehi 4620 3 was be VBD cord-335975-m6lkrehi 4620 4 set set VBN cord-335975-m6lkrehi 4620 5 around around IN cord-335975-m6lkrehi 4620 6 28 28 CD cord-335975-m6lkrehi 4620 7 cycles cycle NNS cord-335975-m6lkrehi 4620 8 minute minute VBP cord-335975-m6lkrehi 4620 9 and and CC cord-335975-m6lkrehi 4620 10 adapted adapt VBD cord-335975-m6lkrehi 4620 11 to to IN cord-335975-m6lkrehi 4620 12 protocols protocol NNS cord-335975-m6lkrehi 4620 13 . . . cord-335975-m6lkrehi 4621 1 Respiratory respiratory JJ cord-335975-m6lkrehi 4621 2 mechanic mechanic NN cord-335975-m6lkrehi 4621 3 after after IN cord-335975-m6lkrehi 4621 4 titration titration NN cord-335975-m6lkrehi 4621 5 was be VBD cord-335975-m6lkrehi 4621 6 recorded record VBN cord-335975-m6lkrehi 4621 7 and and CC cord-335975-m6lkrehi 4621 8 compared compare VBN cord-335975-m6lkrehi 4621 9 to to IN cord-335975-m6lkrehi 4621 10 results result NNS cord-335975-m6lkrehi 4621 11 of of IN cord-335975-m6lkrehi 4621 12 the the DT cord-335975-m6lkrehi 4621 13 2 2 CD cord-335975-m6lkrehi 4621 14 studies study NNS cord-335975-m6lkrehi 4621 15 . . . cord-335975-m6lkrehi 4622 1 Results result NNS cord-335975-m6lkrehi 4622 2 : : : cord-335975-m6lkrehi 4623 1 Results result NNS cord-335975-m6lkrehi 4623 2 are be VBP cord-335975-m6lkrehi 4623 3 summarised summarise VBN cord-335975-m6lkrehi 4623 4 in in IN cord-335975-m6lkrehi 4623 5 the the DT cord-335975-m6lkrehi 4623 6 table table NN cord-335975-m6lkrehi 4623 7 - - : cord-335975-m6lkrehi 4623 8 the the DT cord-335975-m6lkrehi 4623 9 difference difference NN cord-335975-m6lkrehi 4623 10 between between IN cord-335975-m6lkrehi 4623 11 virtual virtual JJ cord-335975-m6lkrehi 4623 12 and and CC cord-335975-m6lkrehi 4623 13 real real JJ cord-335975-m6lkrehi 4623 14 patients patient NNS cord-335975-m6lkrehi 4623 15 were be VBD cord-335975-m6lkrehi 4623 16 not not RB cord-335975-m6lkrehi 4623 17 significant significant JJ cord-335975-m6lkrehi 4623 18 . . . cord-335975-m6lkrehi 4624 1 Vm Vm NNP cord-335975-m6lkrehi 4624 2 L L NNP cord-335975-m6lkrehi 4624 3 / / SYM cord-335975-m6lkrehi 4624 4 min min NNP cord-335975-m6lkrehi 4624 5 12.6 12.6 CD cord-335975-m6lkrehi 4624 6 ( ( -LRB- cord-335975-m6lkrehi 4624 7 4.5 4.5 CD cord-335975-m6lkrehi 4624 8 ) ) -RRB- cord-335975-m6lkrehi 4624 9 13.3 13.3 CD cord-335975-m6lkrehi 4624 10 ( ( -LRB- cord-335975-m6lkrehi 4624 11 1.7 1.7 CD cord-335975-m6lkrehi 4624 12 ) ) -RRB- cord-335975-m6lkrehi 4624 13 12.9 12.9 CD cord-335975-m6lkrehi 4624 14 ( ( -LRB- cord-335975-m6lkrehi 4624 15 3.6 3.6 CD cord-335975-m6lkrehi 4624 16 ) ) -RRB- cord-335975-m6lkrehi 4624 17 13.0 13.0 CD cord-335975-m6lkrehi 4624 18 ( ( -LRB- cord-335975-m6lkrehi 4624 19 2.0 2.0 CD cord-335975-m6lkrehi 4624 20 ) ) -RRB- cord-335975-m6lkrehi 4624 21 11 11 CD cord-335975-m6lkrehi 4624 22 . . . cord-335975-m6lkrehi 4625 1 Ctp Ctp NNP cord-335975-m6lkrehi 4625 2 : : : cord-335975-m6lkrehi 4625 3 tharacopulmanar tharacopulmanar NNP cord-335975-m6lkrehi 4625 4 compliance compliance NN cord-335975-m6lkrehi 4626 1 ( ( -LRB- cord-335975-m6lkrehi 4626 2 ml ml NN cord-335975-m6lkrehi 4626 3 / / SYM cord-335975-m6lkrehi 4626 4 cmH cmh NN cord-335975-m6lkrehi 4626 5 2 2 CD cord-335975-m6lkrehi 4626 6 O o NN cord-335975-m6lkrehi 4626 7 ) ) -RRB- cord-335975-m6lkrehi 4626 8 Discussion discussion NN cord-335975-m6lkrehi 4626 9 : : : cord-335975-m6lkrehi 4626 10 Inspiratory Inspiratory NNP cord-335975-m6lkrehi 4626 11 plateau plateau NN cord-335975-m6lkrehi 4626 12 pressure pressure NN cord-335975-m6lkrehi 4626 13 and and CC cord-335975-m6lkrehi 4626 14 thoraco thoraco NNS cord-335975-m6lkrehi 4626 15 - - HYPH cord-335975-m6lkrehi 4626 16 pulmonary pulmonary JJ cord-335975-m6lkrehi 4626 17 compliance compliance NN cord-335975-m6lkrehi 4626 18 were be VBD cord-335975-m6lkrehi 4626 19 able able JJ cord-335975-m6lkrehi 4626 20 to to TO cord-335975-m6lkrehi 4626 21 change change VB cord-335975-m6lkrehi 4626 22 according accord VBG cord-335975-m6lkrehi 4626 23 to to IN cord-335975-m6lkrehi 4626 24 PEP PEP NNP cord-335975-m6lkrehi 4626 25 or or CC cord-335975-m6lkrehi 4626 26 VT VT NNP cord-335975-m6lkrehi 4626 27 settings setting NNS cord-335975-m6lkrehi 4626 28 within within IN cord-335975-m6lkrehi 4626 29 the the DT cord-335975-m6lkrehi 4626 30 same same JJ cord-335975-m6lkrehi 4626 31 range range NN cord-335975-m6lkrehi 4626 32 as as IN cord-335975-m6lkrehi 4626 33 the the DT cord-335975-m6lkrehi 4626 34 2 2 CD cord-335975-m6lkrehi 4626 35 large large JJ cord-335975-m6lkrehi 4626 36 RCT RCT NNP cord-335975-m6lkrehi 4626 37 studies study NNS cord-335975-m6lkrehi 4626 38 . . . cord-335975-m6lkrehi 4627 1 Mathematical mathematical JJ cord-335975-m6lkrehi 4627 2 model model NN cord-335975-m6lkrehi 4627 3 of of IN cord-335975-m6lkrehi 4627 4 recruitment recruitment NN cord-335975-m6lkrehi 4627 5 was be VBD cord-335975-m6lkrehi 4627 6 adapted adapt VBN cord-335975-m6lkrehi 4627 7 to to TO cord-335975-m6lkrehi 4627 8 create create VB cord-335975-m6lkrehi 4627 9 many many JJ cord-335975-m6lkrehi 4627 10 different different JJ cord-335975-m6lkrehi 4627 11 results result NNS cord-335975-m6lkrehi 4627 12 while while IN cord-335975-m6lkrehi 4627 13 PEP pep NN cord-335975-m6lkrehi 4627 14 was be VBD cord-335975-m6lkrehi 4627 15 titrated titrate VBN cord-335975-m6lkrehi 4627 16 according accord VBG cord-335975-m6lkrehi 4627 17 to to IN cord-335975-m6lkrehi 4627 18 respiratory respiratory JJ cord-335975-m6lkrehi 4627 19 mechanics mechanic NNS cord-335975-m6lkrehi 4627 20 with with IN cord-335975-m6lkrehi 4627 21 the the DT cord-335975-m6lkrehi 4627 22 Express Express NNP cord-335975-m6lkrehi 4627 23 protocol protocol NN cord-335975-m6lkrehi 4627 24 . . . cord-335975-m6lkrehi 4628 1 Conclusion conclusion NN cord-335975-m6lkrehi 4628 2 : : : cord-335975-m6lkrehi 4629 1 Simulation simulation NN cord-335975-m6lkrehi 4629 2 of of IN cord-335975-m6lkrehi 4629 3 artificial artificial JJ cord-335975-m6lkrehi 4629 4 ventilation ventilation NN cord-335975-m6lkrehi 4629 5 with with IN cord-335975-m6lkrehi 4629 6 a a DT cord-335975-m6lkrehi 4629 7 software software NN cord-335975-m6lkrehi 4629 8 can can MD cord-335975-m6lkrehi 4629 9 be be VB cord-335975-m6lkrehi 4629 10 realistic realistic JJ cord-335975-m6lkrehi 4629 11 and and CC cord-335975-m6lkrehi 4629 12 might may MD cord-335975-m6lkrehi 4629 13 be be VB cord-335975-m6lkrehi 4629 14 an an DT cord-335975-m6lkrehi 4629 15 interesting interesting JJ cord-335975-m6lkrehi 4629 16 pedagogical pedagogical JJ cord-335975-m6lkrehi 4629 17 tool tool NN cord-335975-m6lkrehi 4629 18 to to TO cord-335975-m6lkrehi 4629 19 teach teach VB cord-335975-m6lkrehi 4629 20 interactively interactively RB cord-335975-m6lkrehi 4629 21 and and CC cord-335975-m6lkrehi 4629 22 repetidly repetidly RB cord-335975-m6lkrehi 4629 23 ventilatory ventilatory JJ cord-335975-m6lkrehi 4629 24 settings setting NNS cord-335975-m6lkrehi 4629 25 and and CC cord-335975-m6lkrehi 4629 26 respiratory respiratory JJ cord-335975-m6lkrehi 4629 27 mechanics mechanic NNS cord-335975-m6lkrehi 4629 28 interactions interaction NNS cord-335975-m6lkrehi 4629 29 in in IN cord-335975-m6lkrehi 4629 30 ARDS ARDS NNP cord-335975-m6lkrehi 4629 31 without without IN cord-335975-m6lkrehi 4629 32 any any DT cord-335975-m6lkrehi 4629 33 risk risk NN cord-335975-m6lkrehi 4629 34 for for IN cord-335975-m6lkrehi 4629 35 the the DT cord-335975-m6lkrehi 4629 36 patient patient NN cord-335975-m6lkrehi 4629 37 in in IN cord-335975-m6lkrehi 4629 38 our -PRON- PRP$ cord-335975-m6lkrehi 4629 39 units unit NNS cord-335975-m6lkrehi 4629 40 . . . cord-335975-m6lkrehi 4630 1 Introduction introduction NN cord-335975-m6lkrehi 4630 2 : : : cord-335975-m6lkrehi 4631 1 Expiratory Expiratory NNP cord-335975-m6lkrehi 4631 2 flow flow NN cord-335975-m6lkrehi 4631 3 limitation limitation NN cord-335975-m6lkrehi 4631 4 ( ( -LRB- cord-335975-m6lkrehi 4631 5 EFL EFL NNP cord-335975-m6lkrehi 4631 6 ) ) -RRB- cord-335975-m6lkrehi 4631 7 has have VBZ cord-335975-m6lkrehi 4631 8 previously previously RB cord-335975-m6lkrehi 4631 9 been be VBN cord-335975-m6lkrehi 4631 10 investigated investigate VBN cord-335975-m6lkrehi 4631 11 in in IN cord-335975-m6lkrehi 4631 12 ARDS ARDS NNP cord-335975-m6lkrehi 4631 13 patients patient NNS cord-335975-m6lkrehi 4631 14 on on IN cord-335975-m6lkrehi 4631 15 zero zero CD cord-335975-m6lkrehi 4631 16 PEEP peep NN cord-335975-m6lkrehi 4631 17 by by IN cord-335975-m6lkrehi 4631 18 using use VBG cord-335975-m6lkrehi 4631 19 negative negative JJ cord-335975-m6lkrehi 4631 20 expiratory expiratory JJ cord-335975-m6lkrehi 4631 21 pressure pressure NN cord-335975-m6lkrehi 4631 22 ( ( -LRB- cord-335975-m6lkrehi 4631 23 NEP NEP NNP cord-335975-m6lkrehi 4631 24 ) ) -RRB- cord-335975-m6lkrehi 4631 25 technique technique NN cord-335975-m6lkrehi 4631 26 on on IN cord-335975-m6lkrehi 4631 27 tidal tidal JJ cord-335975-m6lkrehi 4631 28 breath breath NN cord-335975-m6lkrehi 4631 29 . . . cord-335975-m6lkrehi 4632 1 In in IN cord-335975-m6lkrehi 4632 2 ARDS ARDS NNP cord-335975-m6lkrehi 4632 3 patients patient NNS cord-335975-m6lkrehi 4632 4 with with IN cord-335975-m6lkrehi 4632 5 EFL EFL NNP cord-335975-m6lkrehi 4632 6 PEEP PEEP NNP cord-335975-m6lkrehi 4632 7 10 10 CD cord-335975-m6lkrehi 4632 8 improved improve VBN cord-335975-m6lkrehi 4632 9 oxygenation oxygenation NN cord-335975-m6lkrehi 4632 10 from from IN cord-335975-m6lkrehi 4632 11 intrinsic intrinsic JJ cord-335975-m6lkrehi 4632 12 PEEP peep NN cord-335975-m6lkrehi 4632 13 homogenization homogenization NN cord-335975-m6lkrehi 4632 14 rather rather RB cord-335975-m6lkrehi 4632 15 than than IN cord-335975-m6lkrehi 4632 16 lung lung NN cord-335975-m6lkrehi 4632 17 recruitment recruitment NN cord-335975-m6lkrehi 4632 18 . . . cord-335975-m6lkrehi 4633 1 The the DT cord-335975-m6lkrehi 4633 2 NEP nep NN cord-335975-m6lkrehi 4633 3 technique technique NN cord-335975-m6lkrehi 4633 4 is be VBZ cord-335975-m6lkrehi 4633 5 no no DT cord-335975-m6lkrehi 4633 6 longer long RBR cord-335975-m6lkrehi 4633 7 available available JJ cord-335975-m6lkrehi 4633 8 . . . cord-335975-m6lkrehi 4634 1 As as IN cord-335975-m6lkrehi 4634 2 EFL EFL NNP cord-335975-m6lkrehi 4634 3 should should MD cord-335975-m6lkrehi 4634 4 reflect reflect VB cord-335975-m6lkrehi 4634 5 airway airway NN cord-335975-m6lkrehi 4634 6 closure closure NN cord-335975-m6lkrehi 4634 7 it -PRON- PRP cord-335975-m6lkrehi 4634 8 is be VBZ cord-335975-m6lkrehi 4634 9 important important JJ cord-335975-m6lkrehi 4634 10 to to TO cord-335975-m6lkrehi 4634 11 assess assess VB cord-335975-m6lkrehi 4634 12 it -PRON- PRP cord-335975-m6lkrehi 4634 13 . . . cord-335975-m6lkrehi 4635 1 We -PRON- PRP cord-335975-m6lkrehi 4635 2 described describe VBD cord-335975-m6lkrehi 4635 3 a a DT cord-335975-m6lkrehi 4635 4 new new JJ cord-335975-m6lkrehi 4635 5 technique technique NN cord-335975-m6lkrehi 4635 6 to to TO cord-335975-m6lkrehi 4635 7 assess assess VB cord-335975-m6lkrehi 4635 8 EFL EFL NNP cord-335975-m6lkrehi 4635 9 . . . cord-335975-m6lkrehi 4636 1 Patients patient NNS cord-335975-m6lkrehi 4636 2 and and CC cord-335975-m6lkrehi 4636 3 methods method NNS cord-335975-m6lkrehi 4636 4 : : : cord-335975-m6lkrehi 4636 5 Thirty thirty CD cord-335975-m6lkrehi 4636 6 - - HYPH cord-335975-m6lkrehi 4636 7 nine nine CD cord-335975-m6lkrehi 4636 8 ARDS ARDS NNP cord-335975-m6lkrehi 4636 9 patients patient NNS cord-335975-m6lkrehi 4636 10 ( ( -LRB- cord-335975-m6lkrehi 4636 11 6 6 CD cord-335975-m6lkrehi 4636 12 mild mild JJ cord-335975-m6lkrehi 4636 13 , , , cord-335975-m6lkrehi 4636 14 32 32 CD cord-335975-m6lkrehi 4636 15 moderate moderate JJ cord-335975-m6lkrehi 4636 16 , , , cord-335975-m6lkrehi 4636 17 1 1 CD cord-335975-m6lkrehi 4636 18 severe severe JJ cord-335975-m6lkrehi 4636 19 ) ) -RRB- cord-335975-m6lkrehi 4636 20 were be VBD cord-335975-m6lkrehi 4636 21 investigated investigate VBN cord-335975-m6lkrehi 4636 22 at at IN cord-335975-m6lkrehi 4636 23 PEEP5 peep5 NN cord-335975-m6lkrehi 4637 1 and15 and15 NFP cord-335975-m6lkrehi 4637 2 . . . cord-335975-m6lkrehi 4638 1 They -PRON- PRP cord-335975-m6lkrehi 4638 2 were be VBD cord-335975-m6lkrehi 4638 3 intubated intubate VBN cord-335975-m6lkrehi 4638 4 , , , cord-335975-m6lkrehi 4638 5 mechanically mechanically RB cord-335975-m6lkrehi 4638 6 ventilated ventilate VBN cord-335975-m6lkrehi 4638 7 ( ( -LRB- cord-335975-m6lkrehi 4638 8 Evita Evita NNP cord-335975-m6lkrehi 4638 9 XL XL NNP cord-335975-m6lkrehi 4638 10 ) ) -RRB- cord-335975-m6lkrehi 4638 11 in in IN cord-335975-m6lkrehi 4638 12 volume volume NN cord-335975-m6lkrehi 4638 13 controlled control VBN cord-335975-m6lkrehi 4638 14 mode mode NN cord-335975-m6lkrehi 4638 15 ( ( -LRB- cord-335975-m6lkrehi 4638 16 tidal tidal JJ cord-335975-m6lkrehi 4638 17 volume volume NN cord-335975-m6lkrehi 4638 18 5 5 CD cord-335975-m6lkrehi 4638 19 ± ± NN cord-335975-m6lkrehi 4639 1 1 1 LS cord-335975-m6lkrehi 4640 1 ml ml NNP cord-335975-m6lkrehi 4640 2 kg kg NNP cord-335975-m6lkrehi 4640 3 predicted predict VBD cord-335975-m6lkrehi 4640 4 body body NN cord-335975-m6lkrehi 4640 5 weight weight NN cord-335975-m6lkrehi 4640 6 ) ) -RRB- cord-335975-m6lkrehi 4640 7 in in IN cord-335975-m6lkrehi 4640 8 the the DT cord-335975-m6lkrehi 4640 9 semi semi JJ cord-335975-m6lkrehi 4640 10 - - JJ cord-335975-m6lkrehi 4640 11 recumbent recumbent JJ cord-335975-m6lkrehi 4640 12 position position NN cord-335975-m6lkrehi 4640 13 . . . cord-335975-m6lkrehi 4641 1 Airway airway JJ cord-335975-m6lkrehi 4641 2 pressure pressure NN cord-335975-m6lkrehi 4641 3 and and CC cord-335975-m6lkrehi 4641 4 flow flow NN cord-335975-m6lkrehi 4641 5 measured measure VBN cord-335975-m6lkrehi 4641 6 proximal proximal VBG cord-335975-m6lkrehi 4641 7 the the DT cord-335975-m6lkrehi 4641 8 endotracheal endotracheal NN cord-335975-m6lkrehi 4641 9 tube tube NN cord-335975-m6lkrehi 4641 10 were be VBD cord-335975-m6lkrehi 4641 11 continuously continuously RB cord-335975-m6lkrehi 4641 12 recorded record VBN cord-335975-m6lkrehi 4641 13 ( ( -LRB- cord-335975-m6lkrehi 4641 14 Biopac150 Biopac150 NNP cord-335975-m6lkrehi 4641 15 ) ) -RRB- cord-335975-m6lkrehi 4641 16 . . . cord-335975-m6lkrehi 4642 1 We -PRON- PRP cord-335975-m6lkrehi 4642 2 measured measure VBD cord-335975-m6lkrehi 4642 3 respiratory respiratory JJ cord-335975-m6lkrehi 4642 4 mechanics mechanic NNS cord-335975-m6lkrehi 4642 5 by by IN cord-335975-m6lkrehi 4642 6 the the DT cord-335975-m6lkrehi 4642 7 occlusion occlusion NN cord-335975-m6lkrehi 4642 8 technique technique NN cord-335975-m6lkrehi 4642 9 at at IN cord-335975-m6lkrehi 4642 10 each each DT cord-335975-m6lkrehi 4642 11 PEEP peep NN cord-335975-m6lkrehi 4642 12 and and CC cord-335975-m6lkrehi 4642 13 recruited recruit VBD cord-335975-m6lkrehi 4642 14 lung lung NN cord-335975-m6lkrehi 4642 15 volume volume NN cord-335975-m6lkrehi 4642 16 between between IN cord-335975-m6lkrehi 4642 17 PEEP15 PEEP15 NNP cord-335975-m6lkrehi 4642 18 and and CC cord-335975-m6lkrehi 4642 19 5 5 CD cord-335975-m6lkrehi 4642 20 by by IN cord-335975-m6lkrehi 4642 21 using use VBG cord-335975-m6lkrehi 4642 22 low low JJ cord-335975-m6lkrehi 4642 23 flow flow NN cord-335975-m6lkrehi 4642 24 inflation inflation NN cord-335975-m6lkrehi 4642 25 method method NN cord-335975-m6lkrehi 4642 26 associated associate VBN cord-335975-m6lkrehi 4642 27 with with IN cord-335975-m6lkrehi 4642 28 measurement measurement NN cord-335975-m6lkrehi 4642 29 in in IN cord-335975-m6lkrehi 4642 30 change change NN cord-335975-m6lkrehi 4642 31 in in IN cord-335975-m6lkrehi 4642 32 end end NN cord-335975-m6lkrehi 4642 33 - - HYPH cord-335975-m6lkrehi 4642 34 expiratory expiratory NN cord-335975-m6lkrehi 4642 35 lung lung NN cord-335975-m6lkrehi 4642 36 volume volume NN cord-335975-m6lkrehi 4642 37 . . . cord-335975-m6lkrehi 4643 1 For for IN cord-335975-m6lkrehi 4643 2 the the DT cord-335975-m6lkrehi 4643 3 latter latter JJ cord-335975-m6lkrehi 4643 4 , , , cord-335975-m6lkrehi 4643 5 patient patient JJ cord-335975-m6lkrehi 4643 6 was be VBD cord-335975-m6lkrehi 4643 7 manually manually RB cord-335975-m6lkrehi 4643 8 disconnected disconnect VBN cord-335975-m6lkrehi 4643 9 at at IN cord-335975-m6lkrehi 4643 10 the the DT cord-335975-m6lkrehi 4643 11 end end NN cord-335975-m6lkrehi 4643 12 of of IN cord-335975-m6lkrehi 4643 13 baseline baseline JJ cord-335975-m6lkrehi 4643 14 tidal tidal JJ cord-335975-m6lkrehi 4643 15 inflation inflation NN cord-335975-m6lkrehi 4643 16 downstream downstream JJ cord-335975-m6lkrehi 4643 17 pneumotachograph pneumotachograph NN cord-335975-m6lkrehi 4643 18 to to IN cord-335975-m6lkrehi 4643 19 atmosphere atmosphere NN cord-335975-m6lkrehi 4643 20 til til IN cord-335975-m6lkrehi 4643 21 zero zero CD cord-335975-m6lkrehi 4643 22 flow flow NN cord-335975-m6lkrehi 4643 23 , , , cord-335975-m6lkrehi 4643 24 then then RB cord-335975-m6lkrehi 4643 25 reconnected reconnecte VBD cord-335975-m6lkrehi 4643 26 at at IN cord-335975-m6lkrehi 4643 27 previous previous JJ cord-335975-m6lkrehi 4643 28 settings setting NNS cord-335975-m6lkrehi 4643 29 . . . cord-335975-m6lkrehi 4644 1 EFL EFL NNP cord-335975-m6lkrehi 4644 2 was be VBD cord-335975-m6lkrehi 4644 3 assessed assess VBN cord-335975-m6lkrehi 4644 4 offline offline RB cord-335975-m6lkrehi 4644 5 by by IN cord-335975-m6lkrehi 4644 6 superimposing superimpose VBG cord-335975-m6lkrehi 4644 7 flow flow NN cord-335975-m6lkrehi 4644 8 - - HYPH cord-335975-m6lkrehi 4644 9 volume volume NN cord-335975-m6lkrehi 4644 10 loops loop NNS cord-335975-m6lkrehi 4644 11 of of IN cord-335975-m6lkrehi 4644 12 disconnected disconnected JJ cord-335975-m6lkrehi 4644 13 and and CC cord-335975-m6lkrehi 4644 14 baseline baseline JJ cord-335975-m6lkrehi 4644 15 breath breath NN cord-335975-m6lkrehi 4644 16 . . . cord-335975-m6lkrehi 4645 1 EFL EFL NNP cord-335975-m6lkrehi 4645 2 was be VBD cord-335975-m6lkrehi 4645 3 defined define VBN cord-335975-m6lkrehi 4645 4 if if IN cord-335975-m6lkrehi 4645 5 no no DT cord-335975-m6lkrehi 4645 6 change change NN cord-335975-m6lkrehi 4645 7 in in IN cord-335975-m6lkrehi 4645 8 flow flow NN cord-335975-m6lkrehi 4645 9 occurred occur VBD cord-335975-m6lkrehi 4645 10 over over IN cord-335975-m6lkrehi 4645 11 all all DT cord-335975-m6lkrehi 4645 12 or or CC cord-335975-m6lkrehi 4645 13 part part NN cord-335975-m6lkrehi 4645 14 of of IN cord-335975-m6lkrehi 4645 15 the the DT cord-335975-m6lkrehi 4645 16 disconnected disconnected JJ cord-335975-m6lkrehi 4645 17 expiration expiration NN cord-335975-m6lkrehi 4645 18 as as IN cord-335975-m6lkrehi 4645 19 compared compare VBN cord-335975-m6lkrehi 4645 20 to to IN cord-335975-m6lkrehi 4645 21 the the DT cord-335975-m6lkrehi 4645 22 baseline baseline JJ cord-335975-m6lkrehi 4645 23 breath breath NN cord-335975-m6lkrehi 4645 24 and and CC cord-335975-m6lkrehi 4645 25 no no DT cord-335975-m6lkrehi 4645 26 EFL EFL NNP cord-335975-m6lkrehi 4645 27 ( ( -LRB- cord-335975-m6lkrehi 4645 28 NFL NFL NNP cord-335975-m6lkrehi 4645 29 ) ) -RRB- cord-335975-m6lkrehi 4645 30 if if IN cord-335975-m6lkrehi 4645 31 any any DT cord-335975-m6lkrehi 4645 32 increase increase NN cord-335975-m6lkrehi 4645 33 in in IN cord-335975-m6lkrehi 4645 34 flow flow NN cord-335975-m6lkrehi 4645 35 during during IN cord-335975-m6lkrehi 4645 36 the the DT cord-335975-m6lkrehi 4645 37 expiration expiration NN cord-335975-m6lkrehi 4645 38 was be VBD cord-335975-m6lkrehi 4645 39 present present JJ cord-335975-m6lkrehi 4646 1 ( ( -LRB- cord-335975-m6lkrehi 4646 2 Fig Fig NNP cord-335975-m6lkrehi 4646 3 . . NNP cord-335975-m6lkrehi 4646 4 1 1 CD cord-335975-m6lkrehi 4646 5 ) ) -RRB- cord-335975-m6lkrehi 4646 6 . . . cord-335975-m6lkrehi 4647 1 The the DT cord-335975-m6lkrehi 4647 2 percentage percentage NN cord-335975-m6lkrehi 4647 3 of of IN cord-335975-m6lkrehi 4647 4 the the DT cord-335975-m6lkrehi 4647 5 tidal tidal JJ cord-335975-m6lkrehi 4647 6 volume volume NN cord-335975-m6lkrehi 4647 7 involved involve VBN cord-335975-m6lkrehi 4647 8 in in IN cord-335975-m6lkrehi 4647 9 EFL EFL NNP cord-335975-m6lkrehi 4647 10 was be VBD cord-335975-m6lkrehi 4647 11 measured measure VBN cord-335975-m6lkrehi 4647 12 . . . cord-335975-m6lkrehi 4648 1 Results result NNS cord-335975-m6lkrehi 4648 2 : : : cord-335975-m6lkrehi 4649 1 EFL EFL NNP cord-335975-m6lkrehi 4649 2 was be VBD cord-335975-m6lkrehi 4649 3 present present JJ cord-335975-m6lkrehi 4649 4 in in IN cord-335975-m6lkrehi 4649 5 7 7 CD cord-335975-m6lkrehi 4649 6 patients patient NNS cord-335975-m6lkrehi 4649 7 ( ( -LRB- cord-335975-m6lkrehi 4649 8 18 18 CD cord-335975-m6lkrehi 4649 9 % % NN cord-335975-m6lkrehi 4649 10 ) ) -RRB- cord-335975-m6lkrehi 4649 11 over over IN cord-335975-m6lkrehi 4649 12 80 80 CD cord-335975-m6lkrehi 4649 13 % % NN cord-335975-m6lkrehi 4649 14 of of IN cord-335975-m6lkrehi 4649 15 the the DT cord-335975-m6lkrehi 4649 16 tidal tidal JJ cord-335975-m6lkrehi 4649 17 expiration expiration NN cord-335975-m6lkrehi 4649 18 . . . cord-335975-m6lkrehi 4650 1 Patients patient NNS cord-335975-m6lkrehi 4650 2 with with IN cord-335975-m6lkrehi 4650 3 EFL EFL NNP cord-335975-m6lkrehi 4650 4 had have VBD cord-335975-m6lkrehi 4650 5 significant significant JJ cord-335975-m6lkrehi 4650 6 higher high JJR cord-335975-m6lkrehi 4650 7 body body NN cord-335975-m6lkrehi 4650 8 mass mass NN cord-335975-m6lkrehi 4650 9 index index NN cord-335975-m6lkrehi 4650 10 ( ( -LRB- cord-335975-m6lkrehi 4651 1 34 34 CD cord-335975-m6lkrehi 4651 2 ± ± CD cord-335975-m6lkrehi 4651 3 7 7 CD cord-335975-m6lkrehi 4651 4 vs. vs. NN cord-335975-m6lkrehi 4651 5 28 28 CD cord-335975-m6lkrehi 4651 6 ± ± NNP cord-335975-m6lkrehi 4651 7 6 6 CD cord-335975-m6lkrehi 4651 8 kg kg NN cord-335975-m6lkrehi 4651 9 m m CD cord-335975-m6lkrehi 4651 10 2 2 CD cord-335975-m6lkrehi 4651 11 , , , cord-335975-m6lkrehi 4651 12 p p NN cord-335975-m6lkrehi 4651 13 < < XX cord-335975-m6lkrehi 4651 14 0.05 0.05 CD cord-335975-m6lkrehi 4651 15 ) ) -RRB- cord-335975-m6lkrehi 4652 1 and and CC cord-335975-m6lkrehi 4652 2 totalPEEP totalPEEP NNS cord-335975-m6lkrehi 4652 3 at at IN cord-335975-m6lkrehi 4652 4 PEEP5 PEEP5 NNP cord-335975-m6lkrehi 4652 5 ( ( -LRB- cord-335975-m6lkrehi 4652 6 7 7 CD cord-335975-m6lkrehi 4652 7 ± ± NNP cord-335975-m6lkrehi 4652 8 1 1 CD cord-335975-m6lkrehi 4652 9 vs. vs. NN cord-335975-m6lkrehi 4652 10 6 6 CD cord-335975-m6lkrehi 4652 11 ± ± NNP cord-335975-m6lkrehi 4652 12 1cmH2O 1cmh2o CD cord-335975-m6lkrehi 4652 13 , , , cord-335975-m6lkrehi 4652 14 p p NN cord-335975-m6lkrehi 4652 15 < < XX cord-335975-m6lkrehi 4652 16 0.05 0.05 CD cord-335975-m6lkrehi 4652 17 ) ) -RRB- cord-335975-m6lkrehi 4652 18 than than IN cord-335975-m6lkrehi 4652 19 NFL NFL NNP cord-335975-m6lkrehi 4652 20 patients patient NNS cord-335975-m6lkrehi 4653 1 and and CC cord-335975-m6lkrehi 4653 2 tended tend VBD cord-335975-m6lkrehi 4653 3 to to TO cord-335975-m6lkrehi 4653 4 be be VB cord-335975-m6lkrehi 4653 5 more more RBR cord-335975-m6lkrehi 4653 6 hypoxemic hypoxemic JJ cord-335975-m6lkrehi 4653 7 . . . cord-335975-m6lkrehi 4654 1 At at IN cord-335975-m6lkrehi 4654 2 PEEP15 PEEP15 NNP cord-335975-m6lkrehi 4654 3 EFL EFL NNP cord-335975-m6lkrehi 4654 4 patients patient NNS cord-335975-m6lkrehi 4654 5 had have VBD cord-335975-m6lkrehi 4654 6 a a DT cord-335975-m6lkrehi 4654 7 significant significant JJ cord-335975-m6lkrehi 4654 8 better well JJR cord-335975-m6lkrehi 4654 9 compliance compliance NN cord-335975-m6lkrehi 4654 10 ( ( -LRB- cord-335975-m6lkrehi 4654 11 50 50 CD cord-335975-m6lkrehi 4654 12 ± ± CD cord-335975-m6lkrehi 4654 13 21 21 CD cord-335975-m6lkrehi 4654 14 vs. vs. NN cord-335975-m6lkrehi 4654 15 30 30 CD cord-335975-m6lkrehi 4654 16 ± ± NN cord-335975-m6lkrehi 4655 1 12 12 CD cord-335975-m6lkrehi 4655 2 ml ml NN cord-335975-m6lkrehi 4655 3 cm cm NN cord-335975-m6lkrehi 4656 1 H h NN cord-335975-m6lkrehi 4656 2 2 2 CD cord-335975-m6lkrehi 4656 3 O o NN cord-335975-m6lkrehi 4656 4 , , , cord-335975-m6lkrehi 4656 5 p p NN cord-335975-m6lkrehi 4656 6 < < XX cord-335975-m6lkrehi 4656 7 0.05 0.05 CD cord-335975-m6lkrehi 4656 8 ) ) -RRB- cord-335975-m6lkrehi 4656 9 with with IN cord-335975-m6lkrehi 4656 10 no no DT cord-335975-m6lkrehi 4656 11 change change NN cord-335975-m6lkrehi 4656 12 in in IN cord-335975-m6lkrehi 4656 13 recruited recruit VBN cord-335975-m6lkrehi 4656 14 lung lung NN cord-335975-m6lkrehi 4656 15 volume volume NN cord-335975-m6lkrehi 4656 16 ( ( -LRB- cord-335975-m6lkrehi 4656 17 393 393 CD cord-335975-m6lkrehi 4656 18 ± ± CD cord-335975-m6lkrehi 4656 19 271 271 CD cord-335975-m6lkrehi 4656 20 vs. vs. NN cord-335975-m6lkrehi 4656 21 347 347 CD cord-335975-m6lkrehi 4656 22 ± ± CD cord-335975-m6lkrehi 4656 23 203 203 CD cord-335975-m6lkrehi 4656 24 ml ml NNS cord-335975-m6lkrehi 4656 25 ) ) -RRB- cord-335975-m6lkrehi 4656 26 and and CC cord-335975-m6lkrehi 4656 27 tended tend VBD cord-335975-m6lkrehi 4656 28 to to TO cord-335975-m6lkrehi 4656 29 be be VB cord-335975-m6lkrehi 4656 30 more more RBR cord-335975-m6lkrehi 4656 31 hypoxemic hypoxemic JJ cord-335975-m6lkrehi 4656 32 than than IN cord-335975-m6lkrehi 4656 33 NFL NFL NNP cord-335975-m6lkrehi 4656 34 patients patient NNS cord-335975-m6lkrehi 4656 35 . . . cord-335975-m6lkrehi 4657 1 Mortality mortality NN cord-335975-m6lkrehi 4657 2 at at IN cord-335975-m6lkrehi 4657 3 ICU ICU NNP cord-335975-m6lkrehi 4657 4 discharge discharge NN cord-335975-m6lkrehi 4657 5 was be VBD cord-335975-m6lkrehi 4657 6 57 57 CD cord-335975-m6lkrehi 4657 7 % % NN cord-335975-m6lkrehi 4657 8 in in IN cord-335975-m6lkrehi 4657 9 EFL EFL NNP cord-335975-m6lkrehi 4657 10 versus versus IN cord-335975-m6lkrehi 4657 11 28 28 CD cord-335975-m6lkrehi 4657 12 % % NN cord-335975-m6lkrehi 4657 13 in in IN cord-335975-m6lkrehi 4657 14 NFL NFL NNP cord-335975-m6lkrehi 4658 1 ( ( -LRB- cord-335975-m6lkrehi 4658 2 p p NN cord-335975-m6lkrehi 4658 3 = = SYM cord-335975-m6lkrehi 4658 4 0.19 0.19 CD cord-335975-m6lkrehi 4658 5 ) ) -RRB- cord-335975-m6lkrehi 4658 6 . . . cord-335975-m6lkrehi 4659 1 Conclusion conclusion NN cord-335975-m6lkrehi 4659 2 : : : cord-335975-m6lkrehi 4659 3 Measurement measurement NN cord-335975-m6lkrehi 4659 4 of of IN cord-335975-m6lkrehi 4659 5 EFL EFL NNP cord-335975-m6lkrehi 4659 6 is be VBZ cord-335975-m6lkrehi 4659 7 feasible feasible JJ cord-335975-m6lkrehi 4659 8 without without IN cord-335975-m6lkrehi 4659 9 the the DT cord-335975-m6lkrehi 4659 10 NEP NEP NNP cord-335975-m6lkrehi 4659 11 technique technique NN cord-335975-m6lkrehi 4659 12 . . . cord-335975-m6lkrehi 4660 1 At at IN cord-335975-m6lkrehi 4660 2 higher high JJR cord-335975-m6lkrehi 4660 3 PEEP PEEP NNP cord-335975-m6lkrehi 4660 4 ARDS ARDS NNP cord-335975-m6lkrehi 4660 5 patients patient NNS cord-335975-m6lkrehi 4660 6 with with IN cord-335975-m6lkrehi 4660 7 EFL EFL NNP cord-335975-m6lkrehi 4660 8 markedly markedly RB cord-335975-m6lkrehi 4660 9 improved improve VBD cord-335975-m6lkrehi 4660 10 compliance compliance NN cord-335975-m6lkrehi 4660 11 of of IN cord-335975-m6lkrehi 4660 12 the the DT cord-335975-m6lkrehi 4660 13 respiratory respiratory JJ cord-335975-m6lkrehi 4660 14 system system NN cord-335975-m6lkrehi 4660 15 not not RB cord-335975-m6lkrehi 4660 16 related relate VBN cord-335975-m6lkrehi 4660 17 to to IN cord-335975-m6lkrehi 4660 18 lung lung NN cord-335975-m6lkrehi 4660 19 recruitment recruitment NN cord-335975-m6lkrehi 4660 20 . . . cord-335975-m6lkrehi 4661 1 Further further JJ cord-335975-m6lkrehi 4661 2 studies study NNS cord-335975-m6lkrehi 4661 3 are be VBP cord-335975-m6lkrehi 4661 4 required require VBN cord-335975-m6lkrehi 4661 5 to to TO cord-335975-m6lkrehi 4661 6 better well RBR cord-335975-m6lkrehi 4661 7 understand understand VB cord-335975-m6lkrehi 4661 8 EFL EFL NNP cord-335975-m6lkrehi 4661 9 in in IN cord-335975-m6lkrehi 4661 10 ARDS ARDS NNP cord-335975-m6lkrehi 4661 11 patients patient NNS cord-335975-m6lkrehi 4661 12 and and CC cord-335975-m6lkrehi 4661 13 to to TO cord-335975-m6lkrehi 4661 14 assess assess VB cord-335975-m6lkrehi 4661 15 its -PRON- PRP$ cord-335975-m6lkrehi 4661 16 impact impact NN cord-335975-m6lkrehi 4661 17 on on IN cord-335975-m6lkrehi 4661 18 patient patient JJ cord-335975-m6lkrehi 4661 19 outcome outcome NN cord-335975-m6lkrehi 4661 20 . . . cord-335975-m6lkrehi 4662 1 limiting limit VBG cord-335975-m6lkrehi 4662 2 factor factor NN cord-335975-m6lkrehi 4662 3 being be VBG cord-335975-m6lkrehi 4662 4 carbon carbon NN cord-335975-m6lkrehi 4662 5 dioxide dioxide NN cord-335975-m6lkrehi 4662 6 accumulation accumulation NN cord-335975-m6lkrehi 4662 7 and and CC cord-335975-m6lkrehi 4662 8 hypercapnic hypercapnic NN cord-335975-m6lkrehi 4662 9 acidosis acidosis NN cord-335975-m6lkrehi 4662 10 . . . cord-335975-m6lkrehi 4663 1 Extra extra JJ cord-335975-m6lkrehi 4663 2 corporeal corporeal JJ cord-335975-m6lkrehi 4663 3 carbon carbon NN cord-335975-m6lkrehi 4663 4 dioxide dioxide NN cord-335975-m6lkrehi 4663 5 removal removal NN cord-335975-m6lkrehi 4663 6 ( ( -LRB- cord-335975-m6lkrehi 4663 7 ECCO2R ecco2r NN cord-335975-m6lkrehi 4663 8 ) ) -RRB- cord-335975-m6lkrehi 4663 9 intervenes intervene VBZ cord-335975-m6lkrehi 4663 10 by by IN cord-335975-m6lkrehi 4663 11 maintaining maintain VBG cord-335975-m6lkrehi 4663 12 ph ph NNP cord-335975-m6lkrehi 4663 13 and and CC cord-335975-m6lkrehi 4663 14 PCO2 PCO2 NNP cord-335975-m6lkrehi 4663 15 within within IN cord-335975-m6lkrehi 4663 16 physiological physiological JJ cord-335975-m6lkrehi 4663 17 ranges range NNS cord-335975-m6lkrehi 4663 18 . . . cord-335975-m6lkrehi 4664 1 This this DT cord-335975-m6lkrehi 4664 2 combination combination NN cord-335975-m6lkrehi 4664 3 is be VBZ cord-335975-m6lkrehi 4664 4 called call VBN cord-335975-m6lkrehi 4664 5 ultra ultra JJ cord-335975-m6lkrehi 4664 6 - - JJ cord-335975-m6lkrehi 4664 7 protective protective JJ cord-335975-m6lkrehi 4664 8 ventilation ventilation NN cord-335975-m6lkrehi 4664 9 . . . cord-335975-m6lkrehi 4665 1 We -PRON- PRP cord-335975-m6lkrehi 4665 2 report report VBP cord-335975-m6lkrehi 4665 3 our -PRON- PRP$ cord-335975-m6lkrehi 4665 4 experience experience NN cord-335975-m6lkrehi 4665 5 with with IN cord-335975-m6lkrehi 4665 6 ECCO2R ECCO2R NNP cord-335975-m6lkrehi 4665 7 in in IN cord-335975-m6lkrehi 4665 8 ARDS ARDS NNP cord-335975-m6lkrehi 4665 9 and and CC cord-335975-m6lkrehi 4665 10 non non NNP cord-335975-m6lkrehi 4665 11 ARDS ARDS NNP cord-335975-m6lkrehi 4665 12 patients patient NNS cord-335975-m6lkrehi 4665 13 with with IN cord-335975-m6lkrehi 4665 14 a a DT cord-335975-m6lkrehi 4665 15 focus focus NN cord-335975-m6lkrehi 4665 16 on on IN cord-335975-m6lkrehi 4665 17 feasibility feasibility NN cord-335975-m6lkrehi 4665 18 and and CC cord-335975-m6lkrehi 4665 19 safety safety NN cord-335975-m6lkrehi 4665 20 . . . cord-335975-m6lkrehi 4666 1 Patients patient NNS cord-335975-m6lkrehi 4666 2 and and CC cord-335975-m6lkrehi 4666 3 methods method NNS cord-335975-m6lkrehi 4666 4 : : : cord-335975-m6lkrehi 4666 5 From from IN cord-335975-m6lkrehi 4666 6 June June NNP cord-335975-m6lkrehi 4666 7 2014 2014 CD cord-335975-m6lkrehi 4666 8 to to IN cord-335975-m6lkrehi 4666 9 July July NNP cord-335975-m6lkrehi 4666 10 2017 2017 CD cord-335975-m6lkrehi 4666 11 all all DT cord-335975-m6lkrehi 4666 12 patients patient NNS cord-335975-m6lkrehi 4666 13 who who WP cord-335975-m6lkrehi 4666 14 have have VBP cord-335975-m6lkrehi 4666 15 undergone undergo VBN cord-335975-m6lkrehi 4666 16 ECCO2R ecco2r NN cord-335975-m6lkrehi 4666 17 in in IN cord-335975-m6lkrehi 4666 18 our -PRON- PRP$ cord-335975-m6lkrehi 4666 19 ICU ICU NNP cord-335975-m6lkrehi 4666 20 were be VBD cord-335975-m6lkrehi 4666 21 included include VBN cord-335975-m6lkrehi 4666 22 consecutively consecutively RB cord-335975-m6lkrehi 4666 23 and and CC cord-335975-m6lkrehi 4666 24 prospectively prospectively RB cord-335975-m6lkrehi 4666 25 . . . cord-335975-m6lkrehi 4667 1 Venovenous Venovenous NNP cord-335975-m6lkrehi 4667 2 ECCO2R ECCO2R NNP cord-335975-m6lkrehi 4667 3 was be VBD cord-335975-m6lkrehi 4667 4 used use VBN cord-335975-m6lkrehi 4667 5 through through IN cord-335975-m6lkrehi 4667 6 a a DT cord-335975-m6lkrehi 4667 7 dual dual JJ cord-335975-m6lkrehi 4667 8 lumen lumen NN cord-335975-m6lkrehi 4667 9 venous venous JJ cord-335975-m6lkrehi 4667 10 catheter catheter NN cord-335975-m6lkrehi 4667 11 ( ( -LRB- cord-335975-m6lkrehi 4667 12 femoral femoral JJ cord-335975-m6lkrehi 4667 13 or or CC cord-335975-m6lkrehi 4667 14 jugular jugular NN cord-335975-m6lkrehi 4667 15 ) ) -RRB- cord-335975-m6lkrehi 4667 16 . . . cord-335975-m6lkrehi 4668 1 Results result NNS cord-335975-m6lkrehi 4668 2 : : : cord-335975-m6lkrehi 4669 1 Nineteen nineteen CD cord-335975-m6lkrehi 4669 2 patients patient NNS cord-335975-m6lkrehi 4669 3 underwent undergo VBD cord-335975-m6lkrehi 4669 4 ECCO2R ecco2r NN cord-335975-m6lkrehi 4669 5 for for IN cord-335975-m6lkrehi 4669 6 a a DT cord-335975-m6lkrehi 4669 7 total total NN cord-335975-m6lkrehi 4669 8 of of IN cord-335975-m6lkrehi 4669 9 21 21 CD cord-335975-m6lkrehi 4669 10 sessions session NNS cord-335975-m6lkrehi 4669 11 . . . cord-335975-m6lkrehi 4670 1 ECCO2R ECCO2R NNP cord-335975-m6lkrehi 4670 2 was be VBD cord-335975-m6lkrehi 4670 3 implemented implement VBN cord-335975-m6lkrehi 4670 4 through through IN cord-335975-m6lkrehi 4670 5 a a DT cord-335975-m6lkrehi 4670 6 dual dual JJ cord-335975-m6lkrehi 4670 7 lumen lumen NN cord-335975-m6lkrehi 4670 8 venous venous JJ cord-335975-m6lkrehi 4670 9 catheter catheter NN cord-335975-m6lkrehi 4670 10 ( ( -LRB- cord-335975-m6lkrehi 4670 11 femoral femoral JJ cord-335975-m6lkrehi 4670 12 or or CC cord-335975-m6lkrehi 4670 13 jugular jugular NN cord-335975-m6lkrehi 4670 14 ) ) -RRB- cord-335975-m6lkrehi 4670 15 with with IN cord-335975-m6lkrehi 4670 16 3 3 CD cord-335975-m6lkrehi 4670 17 different different JJ cord-335975-m6lkrehi 4670 18 devices device NNS cord-335975-m6lkrehi 4670 19 - - : cord-335975-m6lkrehi 4670 20 Hemolung Hemolung NNP cord-335975-m6lkrehi 4670 21 Respiratory Respiratory NNP cord-335975-m6lkrehi 4670 22 Assist Assist NNP cord-335975-m6lkrehi 4670 23 System System NNP cord-335975-m6lkrehi 4670 24 ® ® . cord-335975-m6lkrehi 4670 25 ( ( -LRB- cord-335975-m6lkrehi 4670 26 ALung ALung NNP cord-335975-m6lkrehi 4670 27 ) ) -RRB- cord-335975-m6lkrehi 4671 1 ( ( -LRB- cord-335975-m6lkrehi 4671 2 n n NN cord-335975-m6lkrehi 4671 3 = = SYM cord-335975-m6lkrehi 4671 4 2 2 CD cord-335975-m6lkrehi 4671 5 ) ) -RRB- cord-335975-m6lkrehi 4671 6 , , , cord-335975-m6lkrehi 4671 7 iLA iLA '' cord-335975-m6lkrehi 4671 8 activve activve NNP cord-335975-m6lkrehi 4672 1 ® ® NNP cord-335975-m6lkrehi 4672 2 ( ( -LRB- cord-335975-m6lkrehi 4672 3 Novalung Novalung NNP cord-335975-m6lkrehi 4672 4 ) ) -RRB- cord-335975-m6lkrehi 4673 1 ( ( -LRB- cord-335975-m6lkrehi 4673 2 n n NN cord-335975-m6lkrehi 4673 3 = = SYM cord-335975-m6lkrehi 4673 4 5 5 CD cord-335975-m6lkrehi 4673 5 ) ) -RRB- cord-335975-m6lkrehi 4673 6 and and CC cord-335975-m6lkrehi 4673 7 Prismalung Prismalung NNP cord-335975-m6lkrehi 4673 8 ® ® . cord-335975-m6lkrehi 4673 9 ( ( -LRB- cord-335975-m6lkrehi 4673 10 Prismaflex Prismaflex NNP cord-335975-m6lkrehi 4673 11 system system NN cord-335975-m6lkrehi 4673 12 ) ) -RRB- cord-335975-m6lkrehi 4674 1 ( ( -LRB- cord-335975-m6lkrehi 4674 2 n n NN cord-335975-m6lkrehi 4674 3 = = SYM cord-335975-m6lkrehi 4674 4 12 12 CD cord-335975-m6lkrehi 4674 5 ) ) -RRB- cord-335975-m6lkrehi 4674 6 . . . cord-335975-m6lkrehi 4675 1 Sessions session NNS cord-335975-m6lkrehi 4675 2 were be VBD cord-335975-m6lkrehi 4675 3 3 3 CD cord-335975-m6lkrehi 4675 4 ( ( -LRB- cord-335975-m6lkrehi 4675 5 IQR IQR NNP cord-335975-m6lkrehi 4675 6 2.5 2.5 CD cord-335975-m6lkrehi 4675 7 - - SYM cord-335975-m6lkrehi 4675 8 4.0 4.0 CD cord-335975-m6lkrehi 4675 9 ) ) -RRB- cord-335975-m6lkrehi 4675 10 days day NNS cord-335975-m6lkrehi 4675 11 long long RB cord-335975-m6lkrehi 4675 12 . . . cord-335975-m6lkrehi 4676 1 Catheter catheter NN cord-335975-m6lkrehi 4676 2 diameters diameter NNS cord-335975-m6lkrehi 4676 3 were be VBD cord-335975-m6lkrehi 4676 4 13 13 CD cord-335975-m6lkrehi 4676 5 Fr Fr NNP cord-335975-m6lkrehi 4676 6 ( ( -LRB- cord-335975-m6lkrehi 4676 7 n n NN cord-335975-m6lkrehi 4676 8 = = SYM cord-335975-m6lkrehi 4676 9 8) 8) NNP cord-335975-m6lkrehi 4676 10 , , , cord-335975-m6lkrehi 4676 11 15 15 CD cord-335975-m6lkrehi 4676 12 Fr Fr NNP cord-335975-m6lkrehi 4676 13 ( ( -LRB- cord-335975-m6lkrehi 4676 14 n n NN cord-335975-m6lkrehi 4676 15 = = SYM cord-335975-m6lkrehi 4676 16 6 6 CD cord-335975-m6lkrehi 4676 17 ) ) -RRB- cord-335975-m6lkrehi 4676 18 , , , cord-335975-m6lkrehi 4676 19 24 24 CD cord-335975-m6lkrehi 4676 20 Fr Fr NNP cord-335975-m6lkrehi 4676 21 ( ( -LRB- cord-335975-m6lkrehi 4676 22 n n NN cord-335975-m6lkrehi 4676 23 = = SYM cord-335975-m6lkrehi 4676 24 4 4 CD cord-335975-m6lkrehi 4676 25 ) ) -RRB- cord-335975-m6lkrehi 4676 26 and and CC cord-335975-m6lkrehi 4676 27 17 17 CD cord-335975-m6lkrehi 4676 28 Fr Fr NNP cord-335975-m6lkrehi 4676 29 ( ( -LRB- cord-335975-m6lkrehi 4676 30 n n NN cord-335975-m6lkrehi 4676 31 = = SYM cord-335975-m6lkrehi 4676 32 1 1 CD cord-335975-m6lkrehi 4676 33 ) ) -RRB- cord-335975-m6lkrehi 4676 34 . . . cord-335975-m6lkrehi 4677 1 Thirteen thirteen CD cord-335975-m6lkrehi 4677 2 patients patient NNS cord-335975-m6lkrehi 4677 3 suffered suffer VBD cord-335975-m6lkrehi 4677 4 from from IN cord-335975-m6lkrehi 4677 5 ARDS ARDS NNP cord-335975-m6lkrehi 4677 6 and and CC cord-335975-m6lkrehi 4677 7 6 6 CD cord-335975-m6lkrehi 4677 8 had have VBD cord-335975-m6lkrehi 4677 9 non non JJ cord-335975-m6lkrehi 4677 10 ARDS ARDS NNP cord-335975-m6lkrehi 4677 11 indications indication NNS cord-335975-m6lkrehi 4677 12 for for IN cord-335975-m6lkrehi 4677 13 ECCO2R ecco2r NN cord-335975-m6lkrehi 4677 14 , , , cord-335975-m6lkrehi 4677 15 including include VBG cord-335975-m6lkrehi 4677 16 ultraprotective ultraprotective JJ cord-335975-m6lkrehi 4677 17 ventilation ventilation NN cord-335975-m6lkrehi 4677 18 . . . cord-335975-m6lkrehi 4678 1 Tidal tidal JJ cord-335975-m6lkrehi 4678 2 volume volume NN cord-335975-m6lkrehi 4678 3 decreased decrease VBD cord-335975-m6lkrehi 4678 4 during during IN cord-335975-m6lkrehi 4678 5 ECCO2R ECCO2R NNP cord-335975-m6lkrehi 4678 6 from from IN cord-335975-m6lkrehi 4678 7 5.3 5.3 CD cord-335975-m6lkrehi 4678 8 ( ( -LRB- cord-335975-m6lkrehi 4678 9 IQR IQR NNP cord-335975-m6lkrehi 4678 10 4.3 4.3 CD cord-335975-m6lkrehi 4678 11 - - SYM cord-335975-m6lkrehi 4678 12 5.8 5.8 CD cord-335975-m6lkrehi 4678 13 ) ) -RRB- cord-335975-m6lkrehi 4678 14 to to IN cord-335975-m6lkrehi 4678 15 3.4 3.4 CD cord-335975-m6lkrehi 4679 1 ( ( -LRB- cord-335975-m6lkrehi 4679 2 IQR IQR NNP cord-335975-m6lkrehi 4679 3 2.6 2.6 CD cord-335975-m6lkrehi 4679 4 - - SYM cord-335975-m6lkrehi 4679 5 4.1 4.1 CD cord-335975-m6lkrehi 4679 6 ) ) -RRB- cord-335975-m6lkrehi 4679 7 ml ml NN cord-335975-m6lkrehi 4679 8 kg kg NNS cord-335975-m6lkrehi 4679 9 of of IN cord-335975-m6lkrehi 4679 10 predicted predict VBN cord-335975-m6lkrehi 4679 11 body body NN cord-335975-m6lkrehi 4679 12 weight weight NN cord-335975-m6lkrehi 4679 13 ( ( -LRB- cord-335975-m6lkrehi 4679 14 p p NN cord-335975-m6lkrehi 4679 15 < < XX cord-335975-m6lkrehi 4679 16 .001 .001 NFP cord-335975-m6lkrehi 4679 17 ) ) -RRB- cord-335975-m6lkrehi 4679 18 while while IN cord-335975-m6lkrehi 4679 19 ECCO2R ECCO2R NNP cord-335975-m6lkrehi 4679 20 allowed allow VBD cord-335975-m6lkrehi 4679 21 maintaining maintain VBG cord-335975-m6lkrehi 4679 22 of of IN cord-335975-m6lkrehi 4679 23 pH pH NNP cord-335975-m6lkrehi 4679 24 and and CC cord-335975-m6lkrehi 4679 25 PCO2 PCO2 NNP cord-335975-m6lkrehi 4679 26 within within IN cord-335975-m6lkrehi 4679 27 acceptable acceptable JJ cord-335975-m6lkrehi 4679 28 range range NN cord-335975-m6lkrehi 4679 29 ( ( -LRB- cord-335975-m6lkrehi 4679 30 Fig fig NN cord-335975-m6lkrehi 4679 31 . . . cord-335975-m6lkrehi 4679 32 1 1 CD cord-335975-m6lkrehi 4679 33 ) ) -RRB- cord-335975-m6lkrehi 4679 34 . . . cord-335975-m6lkrehi 4680 1 Driving drive VBG cord-335975-m6lkrehi 4680 2 pressure pressure NN cord-335975-m6lkrehi 4680 3 decreased decrease VBD cord-335975-m6lkrehi 4680 4 from from IN cord-335975-m6lkrehi 4680 5 17 17 CD cord-335975-m6lkrehi 4680 6 ( ( -LRB- cord-335975-m6lkrehi 4680 7 IQR IQR NNP cord-335975-m6lkrehi 4680 8 11 11 CD cord-335975-m6lkrehi 4680 9 - - SYM cord-335975-m6lkrehi 4680 10 21 21 CD cord-335975-m6lkrehi 4680 11 ) ) -RRB- cord-335975-m6lkrehi 4680 12 to to IN cord-335975-m6lkrehi 4680 13 8 8 CD cord-335975-m6lkrehi 4680 14 ( ( -LRB- cord-335975-m6lkrehi 4680 15 IQR IQR NNP cord-335975-m6lkrehi 4680 16 6 6 CD cord-335975-m6lkrehi 4680 17 - - SYM cord-335975-m6lkrehi 4680 18 14 14 CD cord-335975-m6lkrehi 4680 19 ) ) -RRB- cord-335975-m6lkrehi 4680 20 cm cm . cord-335975-m6lkrehi 4681 1 H h NN cord-335975-m6lkrehi 4682 1 2 2 LS cord-335975-m6lkrehi 4682 2 O o NN cord-335975-m6lkrehi 4682 3 ( ( -LRB- cord-335975-m6lkrehi 4682 4 p p NN cord-335975-m6lkrehi 4682 5 < < XX cord-335975-m6lkrehi 4682 6 .001 .001 CD cord-335975-m6lkrehi 4682 7 ) ) -RRB- cord-335975-m6lkrehi 4682 8 . . . cord-335975-m6lkrehi 4683 1 The the DT cord-335975-m6lkrehi 4683 2 main main JJ cord-335975-m6lkrehi 4683 3 adverse adverse JJ cord-335975-m6lkrehi 4683 4 effect effect NN cord-335975-m6lkrehi 4683 5 was be VBD cord-335975-m6lkrehi 4683 6 thrombocytopenia thrombocytopenia JJ cord-335975-m6lkrehi 4683 7 ( ( -LRB- cord-335975-m6lkrehi 4683 8 8 8 CD cord-335975-m6lkrehi 4683 9 patients patient NNS cord-335975-m6lkrehi 4683 10 ) ) -RRB- cord-335975-m6lkrehi 4683 11 . . . cord-335975-m6lkrehi 4684 1 Six six CD cord-335975-m6lkrehi 4684 2 selected select VBN cord-335975-m6lkrehi 4684 3 patients patient NNS cord-335975-m6lkrehi 4684 4 had have VBD cord-335975-m6lkrehi 4684 5 no no DT cord-335975-m6lkrehi 4684 6 anticoagulation anticoagulation NN cord-335975-m6lkrehi 4684 7 during during IN cord-335975-m6lkrehi 4684 8 ECCO2R ecco2r NN cord-335975-m6lkrehi 4684 9 because because IN cord-335975-m6lkrehi 4684 10 of of IN cord-335975-m6lkrehi 4684 11 high high JJ cord-335975-m6lkrehi 4684 12 bleeding bleeding NN cord-335975-m6lkrehi 4684 13 risk risk NN cord-335975-m6lkrehi 4684 14 . . . cord-335975-m6lkrehi 4685 1 Discussion discussion NN cord-335975-m6lkrehi 4685 2 : : : cord-335975-m6lkrehi 4686 1 Ultra ultra JJ cord-335975-m6lkrehi 4686 2 - - JJ cord-335975-m6lkrehi 4686 3 protective protective JJ cord-335975-m6lkrehi 4686 4 ventilation ventilation NN cord-335975-m6lkrehi 4686 5 was be VBD cord-335975-m6lkrehi 4686 6 achieved achieve VBN cord-335975-m6lkrehi 4686 7 with with IN cord-335975-m6lkrehi 4686 8 a a DT cord-335975-m6lkrehi 4686 9 decrease decrease NN cord-335975-m6lkrehi 4686 10 of of IN cord-335975-m6lkrehi 4686 11 tidal tidal JJ cord-335975-m6lkrehi 4686 12 volumes volume NNS cord-335975-m6lkrehi 4686 13 ( ( -LRB- cord-335975-m6lkrehi 4686 14 Vt Vt NNP cord-335975-m6lkrehi 4686 15 < < XX cord-335975-m6lkrehi 4686 16 4 4 CD cord-335975-m6lkrehi 4686 17 ml ml NN cord-335975-m6lkrehi 4686 18 kg kg NNP cord-335975-m6lkrehi 4686 19 ) ) -RRB- cord-335975-m6lkrehi 4686 20 and and CC cord-335975-m6lkrehi 4686 21 positive positive JJ cord-335975-m6lkrehi 4686 22 pressures pressure NNS cord-335975-m6lkrehi 4686 23 . . . cord-335975-m6lkrehi 4687 1 Few few JJ cord-335975-m6lkrehi 4687 2 data datum NNS cord-335975-m6lkrehi 4687 3 on on IN cord-335975-m6lkrehi 4687 4 ECCO2R ECCO2R NNP cord-335975-m6lkrehi 4687 5 are be VBP cord-335975-m6lkrehi 4687 6 available available JJ cord-335975-m6lkrehi 4687 7 in in IN cord-335975-m6lkrehi 4687 8 patients patient NNS cord-335975-m6lkrehi 4687 9 at at IN cord-335975-m6lkrehi 4687 10 high high JJ cord-335975-m6lkrehi 4687 11 risk risk NN cord-335975-m6lkrehi 4687 12 of of IN cord-335975-m6lkrehi 4687 13 hemorrhagic hemorrhagic JJ cord-335975-m6lkrehi 4687 14 complications complication NNS cord-335975-m6lkrehi 4687 15 , , , cord-335975-m6lkrehi 4687 16 we -PRON- PRP cord-335975-m6lkrehi 4687 17 report report VBP cord-335975-m6lkrehi 4687 18 here here RB cord-335975-m6lkrehi 4687 19 a a DT cord-335975-m6lkrehi 4687 20 subgroup subgroup NN cord-335975-m6lkrehi 4687 21 of of IN cord-335975-m6lkrehi 4687 22 6 6 CD cord-335975-m6lkrehi 4687 23 patients patient NNS cord-335975-m6lkrehi 4687 24 who who WP cord-335975-m6lkrehi 4687 25 underwent undergo VBD cord-335975-m6lkrehi 4687 26 efficiently efficiently RB cord-335975-m6lkrehi 4687 27 ECCO2R ecco2r NN cord-335975-m6lkrehi 4687 28 without without IN cord-335975-m6lkrehi 4687 29 anticoagulation anticoagulation NN cord-335975-m6lkrehi 4687 30 . . . cord-335975-m6lkrehi 4688 1 Six six CD cord-335975-m6lkrehi 4688 2 patients patient NNS cord-335975-m6lkrehi 4688 3 underwent undergo VBD cord-335975-m6lkrehi 4688 4 ECCO2R ECCO2R NNP cord-335975-m6lkrehi 4688 5 for for IN cord-335975-m6lkrehi 4688 6 non non JJ cord-335975-m6lkrehi 4688 7 ARDS ARDS NNP cord-335975-m6lkrehi 4688 8 indications indication NNS cord-335975-m6lkrehi 4688 9 , , , cord-335975-m6lkrehi 4688 10 3 3 CD cord-335975-m6lkrehi 4688 11 of of IN cord-335975-m6lkrehi 4688 12 them -PRON- PRP cord-335975-m6lkrehi 4688 13 had have VBD cord-335975-m6lkrehi 4688 14 no no DT cord-335975-m6lkrehi 4688 15 structural structural JJ cord-335975-m6lkrehi 4688 16 damages damage NNS cord-335975-m6lkrehi 4688 17 to to IN cord-335975-m6lkrehi 4688 18 the the DT cord-335975-m6lkrehi 4688 19 lungs lung NNS cord-335975-m6lkrehi 4688 20 which which WDT cord-335975-m6lkrehi 4688 21 has have VBZ cord-335975-m6lkrehi 4688 22 never never RB cord-335975-m6lkrehi 4688 23 been be VBN cord-335975-m6lkrehi 4688 24 reported report VBN cord-335975-m6lkrehi 4688 25 and and CC cord-335975-m6lkrehi 4688 26 ECCOR ECCOR NNP cord-335975-m6lkrehi 4688 27 allowed allow VBD cord-335975-m6lkrehi 4688 28 implementing implement VBG cord-335975-m6lkrehi 4688 29 ultra ultra JJ cord-335975-m6lkrehi 4688 30 - - JJ cord-335975-m6lkrehi 4688 31 protective protective JJ cord-335975-m6lkrehi 4688 32 ventilation ventilation NN cord-335975-m6lkrehi 4688 33 with with IN cord-335975-m6lkrehi 4688 34 no no DT cord-335975-m6lkrehi 4688 35 major major JJ cord-335975-m6lkrehi 4688 36 adverse adverse JJ cord-335975-m6lkrehi 4688 37 effect effect NN cord-335975-m6lkrehi 4688 38 . . . cord-335975-m6lkrehi 4689 1 We -PRON- PRP cord-335975-m6lkrehi 4689 2 report report VBP cord-335975-m6lkrehi 4689 3 our -PRON- PRP$ cord-335975-m6lkrehi 4689 4 experience experience NN cord-335975-m6lkrehi 4689 5 on on IN cord-335975-m6lkrehi 4689 6 ECCO2R ECCO2R NNP cord-335975-m6lkrehi 4689 7 for for IN cord-335975-m6lkrehi 4689 8 ARDS ARDS NNP cord-335975-m6lkrehi 4689 9 and and CC cord-335975-m6lkrehi 4689 10 non non NNP cord-335975-m6lkrehi 4689 11 ARDS ARDS NNP cord-335975-m6lkrehi 4689 12 indications indication NNS cord-335975-m6lkrehi 4689 13 . . . cord-335975-m6lkrehi 4690 1 Ultra ultra JJ cord-335975-m6lkrehi 4690 2 - - JJ cord-335975-m6lkrehi 4690 3 protective protective JJ cord-335975-m6lkrehi 4690 4 ventilation ventilation NN cord-335975-m6lkrehi 4691 1 ( ( -LRB- cord-335975-m6lkrehi 4691 2 Vt Vt NNP cord-335975-m6lkrehi 4691 3 < < XX cord-335975-m6lkrehi 4691 4 4 4 CD cord-335975-m6lkrehi 4691 5 ml ml NN cord-335975-m6lkrehi 4691 6 kg kg NNP cord-335975-m6lkrehi 4691 7 ) ) -RRB- cord-335975-m6lkrehi 4691 8 was be VBD cord-335975-m6lkrehi 4691 9 safe safe JJ cord-335975-m6lkrehi 4691 10 and and CC cord-335975-m6lkrehi 4691 11 feasible feasible JJ cord-335975-m6lkrehi 4691 12 . . . cord-335975-m6lkrehi 4692 1 The the DT cord-335975-m6lkrehi 4692 2 impact impact NN cord-335975-m6lkrehi 4692 3 of of IN cord-335975-m6lkrehi 4692 4 general general JJ cord-335975-m6lkrehi 4692 5 practitioners practitioner NNS cord-335975-m6lkrehi 4692 6 consultation consultation NN cord-335975-m6lkrehi 4692 7 on on IN cord-335975-m6lkrehi 4692 8 ARDS ARDS NNP cord-335975-m6lkrehi 4692 9 complicating complicate VBG cord-335975-m6lkrehi 4692 10 community community NN cord-335975-m6lkrehi 4692 11 acquired acquire VBD cord-335975-m6lkrehi 4692 12 pneumonia pneumonia NN cord-335975-m6lkrehi 4692 13 Donval Donval NNP cord-335975-m6lkrehi 4692 14 Ulysse Ulysse NNP cord-335975-m6lkrehi 4692 15 1 1 CD cord-335975-m6lkrehi 4692 16 , , , cord-335975-m6lkrehi 4692 17 Tadie Tadie NNP cord-335975-m6lkrehi 4692 18 Introduction introduction NN cord-335975-m6lkrehi 4692 19 : : : cord-335975-m6lkrehi 4692 20 Community community NN cord-335975-m6lkrehi 4692 21 - - HYPH cord-335975-m6lkrehi 4692 22 acquired acquire VBN cord-335975-m6lkrehi 4692 23 pneumonia pneumonia NN cord-335975-m6lkrehi 4692 24 ( ( -LRB- cord-335975-m6lkrehi 4692 25 CAP CAP NNP cord-335975-m6lkrehi 4692 26 ) ) -RRB- cord-335975-m6lkrehi 4692 27 is be VBZ cord-335975-m6lkrehi 4692 28 a a DT cord-335975-m6lkrehi 4692 29 potentially potentially RB cord-335975-m6lkrehi 4692 30 severe severe JJ cord-335975-m6lkrehi 4692 31 infection infection NN cord-335975-m6lkrehi 4692 32 that that WDT cord-335975-m6lkrehi 4692 33 results result VBZ cord-335975-m6lkrehi 4692 34 in in IN cord-335975-m6lkrehi 4692 35 numerous numerous JJ cord-335975-m6lkrehi 4692 36 general general JJ cord-335975-m6lkrehi 4692 37 practitioner practitioner NN cord-335975-m6lkrehi 4692 38 ( ( -LRB- cord-335975-m6lkrehi 4692 39 GP GP NNP cord-335975-m6lkrehi 4692 40 ) ) -RRB- cord-335975-m6lkrehi 4692 41 visits visit NNS cord-335975-m6lkrehi 4692 42 and and CC cord-335975-m6lkrehi 4692 43 hospital hospital NN cord-335975-m6lkrehi 4692 44 admissions admission NNS cord-335975-m6lkrehi 4692 45 each each DT cord-335975-m6lkrehi 4692 46 year year NN cord-335975-m6lkrehi 4692 47 . . . cord-335975-m6lkrehi 4693 1 CAP CAP NNP cord-335975-m6lkrehi 4693 2 is be VBZ cord-335975-m6lkrehi 4693 3 also also RB cord-335975-m6lkrehi 4693 4 the the DT cord-335975-m6lkrehi 4693 5 most most RBS cord-335975-m6lkrehi 4693 6 frequent frequent JJ cord-335975-m6lkrehi 4693 7 single single JJ cord-335975-m6lkrehi 4693 8 cause cause NN cord-335975-m6lkrehi 4693 9 of of IN cord-335975-m6lkrehi 4693 10 acute acute JJ cord-335975-m6lkrehi 4693 11 respiratory respiratory JJ cord-335975-m6lkrehi 4693 12 distress distress NN cord-335975-m6lkrehi 4693 13 syndrome syndrome NN cord-335975-m6lkrehi 4693 14 ( ( -LRB- cord-335975-m6lkrehi 4693 15 ARDS ARDS NNP cord-335975-m6lkrehi 4693 16 ) ) -RRB- cord-335975-m6lkrehi 4693 17 . . . cord-335975-m6lkrehi 4694 1 Risk risk NN cord-335975-m6lkrehi 4694 2 factors factor NNS cord-335975-m6lkrehi 4694 3 for for IN cord-335975-m6lkrehi 4694 4 development development NN cord-335975-m6lkrehi 4694 5 of of IN cord-335975-m6lkrehi 4694 6 ARDS ARDS NNP cord-335975-m6lkrehi 4694 7 in in IN cord-335975-m6lkrehi 4694 8 the the DT cord-335975-m6lkrehi 4694 9 course course NN cord-335975-m6lkrehi 4694 10 of of IN cord-335975-m6lkrehi 4694 11 CAP CAP NNP cord-335975-m6lkrehi 4694 12 are be VBP cord-335975-m6lkrehi 4694 13 not not RB cord-335975-m6lkrehi 4694 14 clearly clearly RB cord-335975-m6lkrehi 4694 15 defined define VBN cord-335975-m6lkrehi 4694 16 although although IN cord-335975-m6lkrehi 4694 17 prognostic prognostic JJ cord-335975-m6lkrehi 4694 18 factors factor NNS cord-335975-m6lkrehi 4694 19 associated associate VBN cord-335975-m6lkrehi 4694 20 with with IN cord-335975-m6lkrehi 4694 21 mortality mortality NN cord-335975-m6lkrehi 4694 22 have have VBP cord-335975-m6lkrehi 4694 23 been be VBN cord-335975-m6lkrehi 4694 24 extensively extensively RB cord-335975-m6lkrehi 4694 25 studied study VBN cord-335975-m6lkrehi 4694 26 . . . cord-335975-m6lkrehi 4695 1 GP GP NNP cord-335975-m6lkrehi 4695 2 visits visit NNS cord-335975-m6lkrehi 4695 3 , , , cord-335975-m6lkrehi 4695 4 as as IN cord-335975-m6lkrehi 4695 5 an an DT cord-335975-m6lkrehi 4695 6 early early JJ cord-335975-m6lkrehi 4695 7 diagnosis diagnosis NN cord-335975-m6lkrehi 4695 8 and and CC cord-335975-m6lkrehi 4695 9 earlier early JJR cord-335975-m6lkrehi 4695 10 access access NN cord-335975-m6lkrehi 4695 11 to to IN cord-335975-m6lkrehi 4695 12 antibiotics antibiotic NNS cord-335975-m6lkrehi 4695 13 prescription prescription NN cord-335975-m6lkrehi 4695 14 could could MD cord-335975-m6lkrehi 4695 15 significantly significantly RB cord-335975-m6lkrehi 4695 16 affect affect VB cord-335975-m6lkrehi 4695 17 the the DT cord-335975-m6lkrehi 4695 18 course course NN cord-335975-m6lkrehi 4695 19 of of IN cord-335975-m6lkrehi 4695 20 CAP cap NN cord-335975-m6lkrehi 4695 21 . . . cord-335975-m6lkrehi 4696 1 The the DT cord-335975-m6lkrehi 4696 2 aim aim NN cord-335975-m6lkrehi 4696 3 of of IN cord-335975-m6lkrehi 4696 4 the the DT cord-335975-m6lkrehi 4696 5 present present JJ cord-335975-m6lkrehi 4696 6 study study NN cord-335975-m6lkrehi 4696 7 was be VBD cord-335975-m6lkrehi 4696 8 to to TO cord-335975-m6lkrehi 4696 9 evaluate evaluate VB cord-335975-m6lkrehi 4696 10 the the DT cord-335975-m6lkrehi 4696 11 impact impact NN cord-335975-m6lkrehi 4696 12 of of IN cord-335975-m6lkrehi 4696 13 general general JJ cord-335975-m6lkrehi 4696 14 practitioners practitioner NNS cord-335975-m6lkrehi 4696 15 consultation consultation NN cord-335975-m6lkrehi 4696 16 on on IN cord-335975-m6lkrehi 4696 17 ARDS ARDS NNP cord-335975-m6lkrehi 4696 18 complicating complicate VBG cord-335975-m6lkrehi 4696 19 CAP cap NN cord-335975-m6lkrehi 4696 20 admitted admit VBN cord-335975-m6lkrehi 4696 21 to to IN cord-335975-m6lkrehi 4696 22 our -PRON- PRP$ cord-335975-m6lkrehi 4696 23 ICU ICU NNP cord-335975-m6lkrehi 4696 24 . . . cord-335975-m6lkrehi 4697 1 Patients patient NNS cord-335975-m6lkrehi 4697 2 and and CC cord-335975-m6lkrehi 4697 3 methods method NNS cord-335975-m6lkrehi 4698 1 : : : cord-335975-m6lkrehi 4698 2 We -PRON- PRP cord-335975-m6lkrehi 4698 3 retrospectively retrospectively RB cord-335975-m6lkrehi 4698 4 reviewed review VBD cord-335975-m6lkrehi 4698 5 the the DT cord-335975-m6lkrehi 4698 6 medical medical JJ cord-335975-m6lkrehi 4698 7 records record NNS cord-335975-m6lkrehi 4698 8 of of IN cord-335975-m6lkrehi 4698 9 all all DT cord-335975-m6lkrehi 4698 10 patients patient NNS cord-335975-m6lkrehi 4698 11 aged age VBN cord-335975-m6lkrehi 4698 12 over over IN cord-335975-m6lkrehi 4698 13 18 18 CD cord-335975-m6lkrehi 4698 14 years year NNS cord-335975-m6lkrehi 4698 15 admitted admit VBN cord-335975-m6lkrehi 4698 16 between between IN cord-335975-m6lkrehi 4698 17 October October NNP cord-335975-m6lkrehi 4698 18 1 1 CD cord-335975-m6lkrehi 4698 19 , , , cord-335975-m6lkrehi 4698 20 2006 2006 CD cord-335975-m6lkrehi 4698 21 and and CC cord-335975-m6lkrehi 4698 22 December December NNP cord-335975-m6lkrehi 4698 23 31 31 CD cord-335975-m6lkrehi 4698 24 , , , cord-335975-m6lkrehi 4698 25 2015 2015 CD cord-335975-m6lkrehi 4698 26 , , , cord-335975-m6lkrehi 4698 27 for for IN cord-335975-m6lkrehi 4698 28 ARDS ARDS NNP cord-335975-m6lkrehi 4698 29 complicating complicate VBG cord-335975-m6lkrehi 4698 30 community community NN cord-335975-m6lkrehi 4698 31 acquired acquire VBD cord-335975-m6lkrehi 4698 32 pneumonia pneumonia NN cord-335975-m6lkrehi 4698 33 with with IN cord-335975-m6lkrehi 4698 34 a a DT cord-335975-m6lkrehi 4698 35 PaO2 pao2 JJ cord-335975-m6lkrehi 4698 36 FiO FiO NNP cord-335975-m6lkrehi 4698 37 2 2 CD cord-335975-m6lkrehi 4698 38 ratio ratio NN cord-335975-m6lkrehi 4698 39 < < XX cord-335975-m6lkrehi 4698 40 200 200 CD cord-335975-m6lkrehi 4698 41 mmHg mmHg NNS cord-335975-m6lkrehi 4698 42 after after IN cord-335975-m6lkrehi 4698 43 at at RB cord-335975-m6lkrehi 4698 44 least least RBS cord-335975-m6lkrehi 4698 45 12 12 CD cord-335975-m6lkrehi 4698 46 h h NN cord-335975-m6lkrehi 4698 47 of of IN cord-335975-m6lkrehi 4698 48 lung lung NN cord-335975-m6lkrehi 4698 49 protective protective JJ cord-335975-m6lkrehi 4698 50 mechanical mechanical JJ cord-335975-m6lkrehi 4698 51 ventilation ventilation NN cord-335975-m6lkrehi 4698 52 ( ( -LRB- cord-335975-m6lkrehi 4698 53 MV MV NNP cord-335975-m6lkrehi 4698 54 ) ) -RRB- cord-335975-m6lkrehi 4698 55 . . . cord-335975-m6lkrehi 4699 1 Ventilatory ventilatory JJ cord-335975-m6lkrehi 4699 2 modalities modality NNS cord-335975-m6lkrehi 4699 3 for for IN cord-335975-m6lkrehi 4699 4 ARDS ARDS NNP cord-335975-m6lkrehi 4699 5 had have VBD cord-335975-m6lkrehi 4699 6 been be VBN cord-335975-m6lkrehi 4699 7 protocolized protocolize VBN cord-335975-m6lkrehi 4699 8 over over IN cord-335975-m6lkrehi 4699 9 the the DT cord-335975-m6lkrehi 4699 10 study study NN cord-335975-m6lkrehi 4699 11 period period NN cord-335975-m6lkrehi 4699 12 as as IN cord-335975-m6lkrehi 4699 13 our -PRON- PRP$ cord-335975-m6lkrehi 4699 14 ICU ICU NNP cord-335975-m6lkrehi 4699 15 was be VBD cord-335975-m6lkrehi 4699 16 recruiting recruit VBG cord-335975-m6lkrehi 4699 17 patients patient NNS cord-335975-m6lkrehi 4699 18 for for IN cord-335975-m6lkrehi 4699 19 two two CD cord-335975-m6lkrehi 4699 20 consecutive consecutive JJ cord-335975-m6lkrehi 4699 21 multicenter multicenter JJ cord-335975-m6lkrehi 4699 22 trials trial NNS cord-335975-m6lkrehi 4699 23 ( ( -LRB- cord-335975-m6lkrehi 4699 24 Acurasys Acurasys NNP cord-335975-m6lkrehi 4699 25 and and CC cord-335975-m6lkrehi 4699 26 Proseva Proseva NNP cord-335975-m6lkrehi 4699 27 ) ) -RRB- cord-335975-m6lkrehi 4699 28 . . . cord-335975-m6lkrehi 4700 1 Consequently consequently RB cord-335975-m6lkrehi 4700 2 , , , cord-335975-m6lkrehi 4700 3 the the DT cord-335975-m6lkrehi 4700 4 protective protective JJ cord-335975-m6lkrehi 4700 5 ventilatory ventilatory NN cord-335975-m6lkrehi 4700 6 strategy strategy NN cord-335975-m6lkrehi 4700 7 used use VBN cord-335975-m6lkrehi 4700 8 in in IN cord-335975-m6lkrehi 4700 9 these these DT cord-335975-m6lkrehi 4700 10 two two CD cord-335975-m6lkrehi 4700 11 clinical clinical JJ cord-335975-m6lkrehi 4700 12 trials trial NNS cord-335975-m6lkrehi 4700 13 was be VBD cord-335975-m6lkrehi 4700 14 applied apply VBN cord-335975-m6lkrehi 4700 15 to to IN cord-335975-m6lkrehi 4700 16 every every DT cord-335975-m6lkrehi 4700 17 patient patient NN cord-335975-m6lkrehi 4700 18 with with IN cord-335975-m6lkrehi 4700 19 ARDS ARDS NNP cord-335975-m6lkrehi 4700 20 . . . cord-335975-m6lkrehi 4701 1 Patients patient NNS cord-335975-m6lkrehi 4701 2 were be VBD cord-335975-m6lkrehi 4701 3 divided divide VBN cord-335975-m6lkrehi 4701 4 into into IN cord-335975-m6lkrehi 4701 5 two two CD cord-335975-m6lkrehi 4701 6 groups group NNS cord-335975-m6lkrehi 4701 7 according accord VBG cord-335975-m6lkrehi 4701 8 to to IN cord-335975-m6lkrehi 4701 9 whether whether IN cord-335975-m6lkrehi 4701 10 or or CC cord-335975-m6lkrehi 4701 11 not not RB cord-335975-m6lkrehi 4701 12 they -PRON- PRP cord-335975-m6lkrehi 4701 13 visited visit VBD cord-335975-m6lkrehi 4701 14 a a DT cord-335975-m6lkrehi 4701 15 GP GP NNP cord-335975-m6lkrehi 4701 16 before before IN cord-335975-m6lkrehi 4701 17 ICU ICU NNP cord-335975-m6lkrehi 4701 18 admission admission NN cord-335975-m6lkrehi 4701 19 . . . cord-335975-m6lkrehi 4702 1 : : : cord-335975-m6lkrehi 4702 2 216 216 CD cord-335975-m6lkrehi 4702 3 patients patient NNS cord-335975-m6lkrehi 4702 4 were be VBD cord-335975-m6lkrehi 4702 5 admitted admit VBN cord-335975-m6lkrehi 4702 6 for for IN cord-335975-m6lkrehi 4702 7 ARDS ARDS NNP cord-335975-m6lkrehi 4702 8 complicating complicate VBG cord-335975-m6lkrehi 4702 9 CAP cap NN cord-335975-m6lkrehi 4702 10 . . . cord-335975-m6lkrehi 4703 1 114 114 CD cord-335975-m6lkrehi 4703 2 patients patient NNS cord-335975-m6lkrehi 4703 3 ( ( -LRB- cord-335975-m6lkrehi 4703 4 53 53 CD cord-335975-m6lkrehi 4703 5 % % NN cord-335975-m6lkrehi 4703 6 ) ) -RRB- cord-335975-m6lkrehi 4703 7 had have VBD cord-335975-m6lkrehi 4703 8 visited visit VBN cord-335975-m6lkrehi 4703 9 a a DT cord-335975-m6lkrehi 4703 10 GP gp NN cord-335975-m6lkrehi 4703 11 before before IN cord-335975-m6lkrehi 4703 12 admission admission NN cord-335975-m6lkrehi 4703 13 in in IN cord-335975-m6lkrehi 4703 14 ICU ICU NNP cord-335975-m6lkrehi 4703 15 ( ( -LRB- cord-335975-m6lkrehi 4703 16 GP GP NNP cord-335975-m6lkrehi 4703 17 + + SYM cord-335975-m6lkrehi 4703 18 ) ) -RRB- cord-335975-m6lkrehi 4703 19 and and CC cord-335975-m6lkrehi 4703 20 102 102 CD cord-335975-m6lkrehi 4703 21 did do VBD cord-335975-m6lkrehi 4703 22 not not RB cord-335975-m6lkrehi 4703 23 ( ( -LRB- cord-335975-m6lkrehi 4703 24 GP- GP- NNP cord-335975-m6lkrehi 4703 25 ) ) -RRB- cord-335975-m6lkrehi 4703 26 . . . cord-335975-m6lkrehi 4704 1 Analysis analysis NN cord-335975-m6lkrehi 4704 2 of of IN cord-335975-m6lkrehi 4704 3 demographic demographic JJ cord-335975-m6lkrehi 4704 4 data datum NNS cord-335975-m6lkrehi 4704 5 , , , cord-335975-m6lkrehi 4704 6 respiratory respiratory JJ cord-335975-m6lkrehi 4704 7 microbiology microbiology NN cord-335975-m6lkrehi 4704 8 patterns pattern NNS cord-335975-m6lkrehi 4704 9 , , , cord-335975-m6lkrehi 4704 10 ARDS ARDS NNP cord-335975-m6lkrehi 4704 11 severity severity NN cord-335975-m6lkrehi 4704 12 at at IN cord-335975-m6lkrehi 4704 13 admission admission NN cord-335975-m6lkrehi 4704 14 did do VBD cord-335975-m6lkrehi 4704 15 not not RB cord-335975-m6lkrehi 4704 16 show show VB cord-335975-m6lkrehi 4704 17 any any DT cord-335975-m6lkrehi 4704 18 differences difference NNS cord-335975-m6lkrehi 4704 19 between between IN cord-335975-m6lkrehi 4704 20 the the DT cord-335975-m6lkrehi 4704 21 two two CD cord-335975-m6lkrehi 4704 22 groups group NNS cord-335975-m6lkrehi 4704 23 . . . cord-335975-m6lkrehi 4705 1 SOFA sofa NN cord-335975-m6lkrehi 4705 2 score score NN cord-335975-m6lkrehi 4705 3 at at IN cord-335975-m6lkrehi 4705 4 admission admission NN cord-335975-m6lkrehi 4705 5 was be VBD cord-335975-m6lkrehi 4705 6 significantly significantly RB cord-335975-m6lkrehi 4705 7 higher high JJR cord-335975-m6lkrehi 4705 8 in in IN cord-335975-m6lkrehi 4705 9 GP gp NN cord-335975-m6lkrehi 4705 10 - - HYPH cord-335975-m6lkrehi 4705 11 compared compare VBN cord-335975-m6lkrehi 4705 12 to to IN cord-335975-m6lkrehi 4705 13 GP gp NN cord-335975-m6lkrehi 4706 1 + + CC cord-335975-m6lkrehi 4706 2 patients patient NNS cord-335975-m6lkrehi 4706 3 ( ( -LRB- cord-335975-m6lkrehi 4706 4 9.5 9.5 CD cord-335975-m6lkrehi 4706 5 ( ( -LRB- cord-335975-m6lkrehi 4706 6 8 8 CD cord-335975-m6lkrehi 4706 7 - - SYM cord-335975-m6lkrehi 4706 8 13 13 CD cord-335975-m6lkrehi 4706 9 ) ) -RRB- cord-335975-m6lkrehi 4706 10 vs. vs. IN cord-335975-m6lkrehi 4706 11 8.5 8.5 CD cord-335975-m6lkrehi 4706 12 ( ( -LRB- cord-335975-m6lkrehi 4706 13 7 7 CD cord-335975-m6lkrehi 4706 14 - - SYM cord-335975-m6lkrehi 4706 15 10 10 CD cord-335975-m6lkrehi 4706 16 ) ) -RRB- cord-335975-m6lkrehi 4707 1 respectively respectively RB cord-335975-m6lkrehi 4707 2 + + CC cord-335975-m6lkrehi 4707 3 p p NN cord-335975-m6lkrehi 4707 4 = = SYM cord-335975-m6lkrehi 4707 5 0.003 0.003 CD cord-335975-m6lkrehi 4707 6 ) ) -RRB- cord-335975-m6lkrehi 4708 1 although although IN cord-335975-m6lkrehi 4708 2 respiratory respiratory JJ cord-335975-m6lkrehi 4708 3 SOFA sofa NN cord-335975-m6lkrehi 4708 4 scores score NNS cord-335975-m6lkrehi 4708 5 were be VBD cord-335975-m6lkrehi 4708 6 not not RB cord-335975-m6lkrehi 4708 7 different different JJ cord-335975-m6lkrehi 4708 8 ( ( -LRB- cord-335975-m6lkrehi 4708 9 4 4 CD cord-335975-m6lkrehi 4708 10 ( ( -LRB- cord-335975-m6lkrehi 4708 11 3 3 CD cord-335975-m6lkrehi 4708 12 - - SYM cord-335975-m6lkrehi 4708 13 4 4 CD cord-335975-m6lkrehi 4708 14 ) ) -RRB- cord-335975-m6lkrehi 4708 15 vs. vs. NN cord-335975-m6lkrehi 4708 16 4 4 CD cord-335975-m6lkrehi 4708 17 ( ( -LRB- cord-335975-m6lkrehi 4708 18 3 3 CD cord-335975-m6lkrehi 4708 19 - - SYM cord-335975-m6lkrehi 4708 20 4 4 CD cord-335975-m6lkrehi 4708 21 ) ) -RRB- cord-335975-m6lkrehi 4709 1 respectively respectively RB cord-335975-m6lkrehi 4709 2 + + CC cord-335975-m6lkrehi 4709 3 p p NN cord-335975-m6lkrehi 4709 4 = = SYM cord-335975-m6lkrehi 4709 5 0.31 0.31 CD cord-335975-m6lkrehi 4709 6 ) ) -RRB- cord-335975-m6lkrehi 4709 7 . . . cord-335975-m6lkrehi 4710 1 71 71 CD cord-335975-m6lkrehi 4710 2 ( ( -LRB- cord-335975-m6lkrehi 4710 3 70 70 CD cord-335975-m6lkrehi 4710 4 % % NN cord-335975-m6lkrehi 4710 5 ) ) -RRB- cord-335975-m6lkrehi 4710 6 GP-(70 gp-(70 CD cord-335975-m6lkrehi 4710 7 % % NN cord-335975-m6lkrehi 4710 8 ) ) -RRB- cord-335975-m6lkrehi 4710 9 and and CC cord-335975-m6lkrehi 4710 10 60 60 CD cord-335975-m6lkrehi 4710 11 ( ( -LRB- cord-335975-m6lkrehi 4710 12 53 53 CD cord-335975-m6lkrehi 4710 13 % % NN cord-335975-m6lkrehi 4710 14 ) ) -RRB- cord-335975-m6lkrehi 4711 1 GP GP NNP cord-335975-m6lkrehi 4712 1 + + CC cord-335975-m6lkrehi 4712 2 patients patient NNS cord-335975-m6lkrehi 4712 3 presented present VBD cord-335975-m6lkrehi 4712 4 septic septic JJ cord-335975-m6lkrehi 4712 5 shock shock NN cord-335975-m6lkrehi 4712 6 at at IN cord-335975-m6lkrehi 4712 7 ICU ICU NNP cord-335975-m6lkrehi 4712 8 admission admission NN cord-335975-m6lkrehi 4712 9 ( ( -LRB- cord-335975-m6lkrehi 4712 10 p p NN cord-335975-m6lkrehi 4712 11 = = SYM cord-335975-m6lkrehi 4712 12 0.01 0.01 CD cord-335975-m6lkrehi 4712 13 ) ) -RRB- cord-335975-m6lkrehi 4712 14 . . . cord-335975-m6lkrehi 4713 1 Multivariate multivariate JJ cord-335975-m6lkrehi 4713 2 analysis analysis NN cord-335975-m6lkrehi 4713 3 found find VBD cord-335975-m6lkrehi 4713 4 that that IN cord-335975-m6lkrehi 4713 5 GP GP NNP cord-335975-m6lkrehi 4713 6 consultation consultation NN cord-335975-m6lkrehi 4713 7 ( ( -LRB- cord-335975-m6lkrehi 4713 8 0.54 0.54 CD cord-335975-m6lkrehi 4713 9 [ [ -LRB- cord-335975-m6lkrehi 4713 10 0.29 0.29 CD cord-335975-m6lkrehi 4713 11 - - SYM cord-335975-m6lkrehi 4713 12 0.98 0.98 CD cord-335975-m6lkrehi 4713 13 ] ] -RRB- cord-335975-m6lkrehi 4713 14 + + CC cord-335975-m6lkrehi 4713 15 p p NN cord-335975-m6lkrehi 4713 16 = = SYM cord-335975-m6lkrehi 4713 17 0.04 0.04 CD cord-335975-m6lkrehi 4713 18 ) ) -RRB- cord-335975-m6lkrehi 4713 19 with with IN cord-335975-m6lkrehi 4713 20 antibiotics antibiotic NNS cord-335975-m6lkrehi 4713 21 prescription prescription NN cord-335975-m6lkrehi 4713 22 ( ( -LRB- cord-335975-m6lkrehi 4713 23 0.46 0.46 CD cord-335975-m6lkrehi 4713 24 [ [ -LRB- cord-335975-m6lkrehi 4713 25 0.22 0.22 CD cord-335975-m6lkrehi 4713 26 - - HYPH cord-335975-m6lkrehi 4713 27 0.99 0.99 CD cord-335975-m6lkrehi 4713 28 ] ] -RRB- cord-335975-m6lkrehi 4713 29 + + CC cord-335975-m6lkrehi 4713 30 p p NN cord-335975-m6lkrehi 4713 31 = = SYM cord-335975-m6lkrehi 4713 32 0.04 0.04 CD cord-335975-m6lkrehi 4713 33 ) ) -RRB- cord-335975-m6lkrehi 4713 34 were be VBD cord-335975-m6lkrehi 4713 35 associated associate VBN cord-335975-m6lkrehi 4713 36 with with IN cord-335975-m6lkrehi 4713 37 decreased decrease VBN cord-335975-m6lkrehi 4713 38 mortality mortality NN cord-335975-m6lkrehi 4713 39 at at IN cord-335975-m6lkrehi 4713 40 day day NN cord-335975-m6lkrehi 4713 41 28 28 CD cord-335975-m6lkrehi 4713 42 ( ( -LRB- cord-335975-m6lkrehi 4713 43 Fig Fig NNP cord-335975-m6lkrehi 4713 44 . . . cord-335975-m6lkrehi 4713 45 1 1 CD cord-335975-m6lkrehi 4713 46 ) ) -RRB- cord-335975-m6lkrehi 4713 47 . . . cord-335975-m6lkrehi 4714 1 In in IN cord-335975-m6lkrehi 4714 2 patients patient NNS cord-335975-m6lkrehi 4714 3 admitted admit VBN cord-335975-m6lkrehi 4714 4 to to IN cord-335975-m6lkrehi 4714 5 our -PRON- PRP$ cord-335975-m6lkrehi 4714 6 ICU ICU NNP cord-335975-m6lkrehi 4714 7 for for IN cord-335975-m6lkrehi 4714 8 ARDS ARDS NNP cord-335975-m6lkrehi 4714 9 complicating complicate VBG cord-335975-m6lkrehi 4714 10 community community NN cord-335975-m6lkrehi 4714 11 acquired acquire VBD cord-335975-m6lkrehi 4714 12 pneumonia pneumonia NN cord-335975-m6lkrehi 4715 1 , , , cord-335975-m6lkrehi 4715 2 GP GP NNP cord-335975-m6lkrehi 4715 3 visits visit NNS cord-335975-m6lkrehi 4715 4 prior prior RB cord-335975-m6lkrehi 4715 5 to to IN cord-335975-m6lkrehi 4715 6 ICU ICU NNP cord-335975-m6lkrehi 4715 7 admission admission NN cord-335975-m6lkrehi 4715 8 was be VBD cord-335975-m6lkrehi 4715 9 associated associate VBN cord-335975-m6lkrehi 4715 10 with with IN cord-335975-m6lkrehi 4715 11 a a DT cord-335975-m6lkrehi 4715 12 better well JJR cord-335975-m6lkrehi 4715 13 outcome outcome NN cord-335975-m6lkrehi 4715 14 . . . cord-335975-m6lkrehi 4716 1 The the DT cord-335975-m6lkrehi 4716 2 beneficial beneficial JJ cord-335975-m6lkrehi 4716 3 effect effect NN cord-335975-m6lkrehi 4716 4 may may MD cord-335975-m6lkrehi 4716 5 be be VB cord-335975-m6lkrehi 4716 6 due due JJ cord-335975-m6lkrehi 4716 7 to to IN cord-335975-m6lkrehi 4716 8 earlier early JJR cord-335975-m6lkrehi 4716 9 antibiotic antibiotic JJ cord-335975-m6lkrehi 4716 10 prescription prescription NN cord-335975-m6lkrehi 4716 11 which which WDT cord-335975-m6lkrehi 4716 12 could could MD cord-335975-m6lkrehi 4716 13 significantly significantly RB cord-335975-m6lkrehi 4716 14 lowered lower VBN cord-335975-m6lkrehi 4716 15 severe severe JJ cord-335975-m6lkrehi 4716 16 infection infection NN cord-335975-m6lkrehi 4716 17 and and CC cord-335975-m6lkrehi 4716 18 septic septic JJ cord-335975-m6lkrehi 4716 19 shock shock NN cord-335975-m6lkrehi 4716 20 . . . cord-335975-m6lkrehi 4717 1 Introduction introduction NN cord-335975-m6lkrehi 4717 2 : : : cord-335975-m6lkrehi 4718 1 Optimal optimal JJ cord-335975-m6lkrehi 4718 2 PEEP peep NN cord-335975-m6lkrehi 4718 3 level level NN cord-335975-m6lkrehi 4718 4 during during IN cord-335975-m6lkrehi 4718 5 ARDS ARDS NNP cord-335975-m6lkrehi 4718 6 remains remain VBZ cord-335975-m6lkrehi 4718 7 controversial controversial JJ cord-335975-m6lkrehi 4718 8 because because IN cord-335975-m6lkrehi 4718 9 of of IN cord-335975-m6lkrehi 4718 10 its -PRON- PRP$ cord-335975-m6lkrehi 4718 11 beneficial beneficial JJ cord-335975-m6lkrehi 4718 12 and and CC cord-335975-m6lkrehi 4718 13 adverse adverse JJ cord-335975-m6lkrehi 4718 14 effects effect NNS cord-335975-m6lkrehi 4718 15 . . . cord-335975-m6lkrehi 4719 1 The the DT cord-335975-m6lkrehi 4719 2 optimal optimal JJ cord-335975-m6lkrehi 4719 3 level level NN cord-335975-m6lkrehi 4719 4 of of IN cord-335975-m6lkrehi 4719 5 recruitment recruitment NN cord-335975-m6lkrehi 4719 6 and and CC cord-335975-m6lkrehi 4719 7 its -PRON- PRP$ cord-335975-m6lkrehi 4719 8 effect effect NN cord-335975-m6lkrehi 4719 9 on on IN cord-335975-m6lkrehi 4719 10 oxygenation oxygenation NN cord-335975-m6lkrehi 4719 11 are be VBP cord-335975-m6lkrehi 4719 12 not not RB cord-335975-m6lkrehi 4719 13 well well RB cord-335975-m6lkrehi 4719 14 defined define VBN cord-335975-m6lkrehi 4719 15 and and CC cord-335975-m6lkrehi 4719 16 no no DT cord-335975-m6lkrehi 4719 17 technique technique NN cord-335975-m6lkrehi 4719 18 is be VBZ cord-335975-m6lkrehi 4719 19 currently currently RB cord-335975-m6lkrehi 4719 20 validated validate VBN cord-335975-m6lkrehi 4719 21 . . . cord-335975-m6lkrehi 4720 1 The the DT cord-335975-m6lkrehi 4720 2 aim aim NN cord-335975-m6lkrehi 4720 3 of of IN cord-335975-m6lkrehi 4720 4 our -PRON- PRP$ cord-335975-m6lkrehi 4720 5 study study NN cord-335975-m6lkrehi 4720 6 was be VBD cord-335975-m6lkrehi 4720 7 to to TO cord-335975-m6lkrehi 4720 8 evaluate evaluate VB cord-335975-m6lkrehi 4720 9 the the DT cord-335975-m6lkrehi 4720 10 correlation correlation NN cord-335975-m6lkrehi 4720 11 between between IN cord-335975-m6lkrehi 4720 12 the the DT cord-335975-m6lkrehi 4720 13 recruited recruit VBN cord-335975-m6lkrehi 4720 14 pulmonary pulmonary JJ cord-335975-m6lkrehi 4720 15 volume volume NN cord-335975-m6lkrehi 4720 16 estimated estimate VBN cord-335975-m6lkrehi 4720 17 by by IN cord-335975-m6lkrehi 4720 18 a a DT cord-335975-m6lkrehi 4720 19 new new JJ cord-335975-m6lkrehi 4720 20 technique technique NN cord-335975-m6lkrehi 4720 21 ( ( -LRB- cord-335975-m6lkrehi 4720 22 CRF CRF NNP cord-335975-m6lkrehi 4720 23 INview INview NNP cord-335975-m6lkrehi 4720 24 ® ® VBP cord-335975-m6lkrehi 4720 25 ) ) -RRB- cord-335975-m6lkrehi 4720 26 and and CC cord-335975-m6lkrehi 4720 27 the the DT cord-335975-m6lkrehi 4720 28 evolution evolution NN cord-335975-m6lkrehi 4720 29 of of IN cord-335975-m6lkrehi 4720 30 PaO2 PaO2 NNS cord-335975-m6lkrehi 4720 31 as as RB cord-335975-m6lkrehi 4720 32 well well RB cord-335975-m6lkrehi 4720 33 as as IN cord-335975-m6lkrehi 4720 34 the the DT cord-335975-m6lkrehi 4720 35 respiratory respiratory JJ cord-335975-m6lkrehi 4720 36 and and CC cord-335975-m6lkrehi 4720 37 hemodynamic hemodynamic JJ cord-335975-m6lkrehi 4720 38 tolerance tolerance NN cord-335975-m6lkrehi 4720 39 of of IN cord-335975-m6lkrehi 4720 40 the the DT cord-335975-m6lkrehi 4720 41 application application NN cord-335975-m6lkrehi 4720 42 of of IN cord-335975-m6lkrehi 4720 43 an an DT cord-335975-m6lkrehi 4720 44 increasing increase VBG cord-335975-m6lkrehi 4720 45 levels level NNS cord-335975-m6lkrehi 4720 46 of of IN cord-335975-m6lkrehi 4720 47 PEEP peep NN cord-335975-m6lkrehi 4720 48 . . . cord-335975-m6lkrehi 4721 1 Patients patient NNS cord-335975-m6lkrehi 4721 2 and and CC cord-335975-m6lkrehi 4721 3 methods method NNS cord-335975-m6lkrehi 4721 4 : : : cord-335975-m6lkrehi 4721 5 A a DT cord-335975-m6lkrehi 4721 6 prospective prospective JJ cord-335975-m6lkrehi 4721 7 , , , cord-335975-m6lkrehi 4721 8 monocentric monocentric JJ cord-335975-m6lkrehi 4721 9 study study NN cord-335975-m6lkrehi 4721 10 that that WDT cord-335975-m6lkrehi 4721 11 will will MD cord-335975-m6lkrehi 4721 12 last last VB cord-335975-m6lkrehi 4721 13 3 3 CD cord-335975-m6lkrehi 4721 14 years year NNS cord-335975-m6lkrehi 4721 15 ( ( -LRB- cord-335975-m6lkrehi 4721 16 January January NNP cord-335975-m6lkrehi 4721 17 2015-January 2015-january CD cord-335975-m6lkrehi 4721 18 2018 2018 CD cord-335975-m6lkrehi 4721 19 ) ) -RRB- cord-335975-m6lkrehi 4721 20 , , , cord-335975-m6lkrehi 4721 21 taking take VBG cord-335975-m6lkrehi 4721 22 place place NN cord-335975-m6lkrehi 4721 23 in in IN cord-335975-m6lkrehi 4721 24 the the DT cord-335975-m6lkrehi 4721 25 intensive intensive JJ cord-335975-m6lkrehi 4721 26 care care NN cord-335975-m6lkrehi 4721 27 unit unit NN cord-335975-m6lkrehi 4721 28 at at IN cord-335975-m6lkrehi 4721 29 the the DT cord-335975-m6lkrehi 4721 30 military military JJ cord-335975-m6lkrehi 4721 31 teaching teaching NN cord-335975-m6lkrehi 4721 32 hospital hospital NN cord-335975-m6lkrehi 4721 33 of of IN cord-335975-m6lkrehi 4721 34 Tunis Tunis NNP cord-335975-m6lkrehi 4721 35 and and CC cord-335975-m6lkrehi 4721 36 including include VBG cord-335975-m6lkrehi 4721 37 patients patient NNS cord-335975-m6lkrehi 4721 38 if if IN cord-335975-m6lkrehi 4721 39 they -PRON- PRP cord-335975-m6lkrehi 4721 40 met meet VBD cord-335975-m6lkrehi 4721 41 standard standard JJ cord-335975-m6lkrehi 4721 42 criteria criterion NNS cord-335975-m6lkrehi 4721 43 for for IN cord-335975-m6lkrehi 4721 44 ARDS ARDS NNP cord-335975-m6lkrehi 4721 45 ( ( -LRB- cord-335975-m6lkrehi 4721 46 Berlin Berlin NNP cord-335975-m6lkrehi 4721 47 criteria criterion NNS cord-335975-m6lkrehi 4721 48 ) ) -RRB- cord-335975-m6lkrehi 4721 49 . . . cord-335975-m6lkrehi 4722 1 The the DT cord-335975-m6lkrehi 4722 2 main main JJ cord-335975-m6lkrehi 4722 3 criterion criterion NN cord-335975-m6lkrehi 4722 4 for for IN cord-335975-m6lkrehi 4722 5 judgment judgment NN cord-335975-m6lkrehi 4722 6 was be VBD cord-335975-m6lkrehi 4722 7 the the DT cord-335975-m6lkrehi 4722 8 correlation correlation NN cord-335975-m6lkrehi 4722 9 between between IN cord-335975-m6lkrehi 4722 10 the the DT cord-335975-m6lkrehi 4722 11 recruited recruit VBN cord-335975-m6lkrehi 4722 12 pulmonary pulmonary JJ cord-335975-m6lkrehi 4722 13 volume volume NN cord-335975-m6lkrehi 4722 14 estimated estimate VBN cord-335975-m6lkrehi 4722 15 by by IN cord-335975-m6lkrehi 4722 16 a a DT cord-335975-m6lkrehi 4722 17 new new JJ cord-335975-m6lkrehi 4722 18 technique technique NN cord-335975-m6lkrehi 4722 19 ( ( -LRB- cord-335975-m6lkrehi 4722 20 CRF CRF NNP cord-335975-m6lkrehi 4722 21 INview INview NNP cord-335975-m6lkrehi 4722 22 ® ® VBP cord-335975-m6lkrehi 4722 23 ) ) -RRB- cord-335975-m6lkrehi 4722 24 and and CC cord-335975-m6lkrehi 4722 25 the the DT cord-335975-m6lkrehi 4722 26 evolution evolution NN cord-335975-m6lkrehi 4722 27 of of IN cord-335975-m6lkrehi 4722 28 the the DT cord-335975-m6lkrehi 4722 29 PaO2 PaO2 NNPS cord-335975-m6lkrehi 4722 30 after after IN cord-335975-m6lkrehi 4722 31 application application NN cord-335975-m6lkrehi 4722 32 of of IN cord-335975-m6lkrehi 4722 33 three three CD cord-335975-m6lkrehi 4722 34 increasing increase VBG cord-335975-m6lkrehi 4722 35 levels level NNS cord-335975-m6lkrehi 4722 36 of of IN cord-335975-m6lkrehi 4722 37 PEEP peep NN cord-335975-m6lkrehi 4722 38 ( ( -LRB- cord-335975-m6lkrehi 4722 39 5 5 CD cord-335975-m6lkrehi 4722 40 - - SYM cord-335975-m6lkrehi 4722 41 10 10 CD cord-335975-m6lkrehi 4722 42 - - SYM cord-335975-m6lkrehi 4722 43 15 15 CD cord-335975-m6lkrehi 4722 44 ) ) -RRB- cord-335975-m6lkrehi 4722 45 . . . cord-335975-m6lkrehi 4723 1 The the DT cord-335975-m6lkrehi 4723 2 other other JJ cord-335975-m6lkrehi 4723 3 secondary secondary JJ cord-335975-m6lkrehi 4723 4 criteria criterion NNS cord-335975-m6lkrehi 4723 5 were be VBD cord-335975-m6lkrehi 4723 6 the the DT cord-335975-m6lkrehi 4723 7 respiratory respiratory JJ cord-335975-m6lkrehi 4723 8 and and CC cord-335975-m6lkrehi 4723 9 hemodynamic hemodynamic JJ cord-335975-m6lkrehi 4723 10 tolerance tolerance NN cord-335975-m6lkrehi 4723 11 of of IN cord-335975-m6lkrehi 4723 12 the the DT cord-335975-m6lkrehi 4723 13 application application NN cord-335975-m6lkrehi 4723 14 of of IN cord-335975-m6lkrehi 4723 15 increasing increase VBG cord-335975-m6lkrehi 4723 16 levels level NNS cord-335975-m6lkrehi 4723 17 of of IN cord-335975-m6lkrehi 4723 18 PEEP peep NN cord-335975-m6lkrehi 4723 19 measured measure VBN cord-335975-m6lkrehi 4723 20 by by IN cord-335975-m6lkrehi 4723 21 the the DT cord-335975-m6lkrehi 4723 22 PiCCO PiCCO NNP cord-335975-m6lkrehi 4723 23 ® ® NN cord-335975-m6lkrehi 4723 24 technique technique NN cord-335975-m6lkrehi 4723 25 . . . cord-335975-m6lkrehi 4724 1 aimed aim VBN cord-335975-m6lkrehi 4724 2 to to TO cord-335975-m6lkrehi 4724 3 investigate investigate VB cord-335975-m6lkrehi 4724 4 the the DT cord-335975-m6lkrehi 4724 5 concordance concordance NN cord-335975-m6lkrehi 4724 6 between between IN cord-335975-m6lkrehi 4724 7 the the DT cord-335975-m6lkrehi 4724 8 onset onset NN cord-335975-m6lkrehi 4724 9 of of IN cord-335975-m6lkrehi 4724 10 three three CD cord-335975-m6lkrehi 4724 11 VAE VAE NNP cord-335975-m6lkrehi 4724 12 tiers tier NNS cord-335975-m6lkrehi 4724 13 and and CC cord-335975-m6lkrehi 4724 14 VALRTI VALRTI NNS cord-335975-m6lkrehi 4724 15 , , , cord-335975-m6lkrehi 4724 16 and and CC cord-335975-m6lkrehi 4724 17 their -PRON- PRP$ cord-335975-m6lkrehi 4724 18 impact impact NN cord-335975-m6lkrehi 4724 19 on on IN cord-335975-m6lkrehi 4724 20 outcomes outcome NNS cord-335975-m6lkrehi 4724 21 . . . cord-335975-m6lkrehi 4725 1 We -PRON- PRP cord-335975-m6lkrehi 4725 2 performed perform VBD cord-335975-m6lkrehi 4725 3 a a DT cord-335975-m6lkrehi 4725 4 retrospective retrospective JJ cord-335975-m6lkrehi 4725 5 analysis analysis NN cord-335975-m6lkrehi 4725 6 of of IN cord-335975-m6lkrehi 4725 7 prospectively prospectively RB cord-335975-m6lkrehi 4725 8 collected collect VBN cord-335975-m6lkrehi 4725 9 data datum NNS cord-335975-m6lkrehi 4725 10 from from IN cord-335975-m6lkrehi 4725 11 patients patient NNS cord-335975-m6lkrehi 4725 12 requiring require VBG cord-335975-m6lkrehi 4725 13 mechanical mechanical JJ cord-335975-m6lkrehi 4725 14 ventilation ventilation NN cord-335975-m6lkrehi 4725 15 for for IN cord-335975-m6lkrehi 4725 16 more more JJR cord-335975-m6lkrehi 4725 17 than than IN cord-335975-m6lkrehi 4725 18 5 5 CD cord-335975-m6lkrehi 4725 19 days day NNS cord-335975-m6lkrehi 4725 20 in in IN cord-335975-m6lkrehi 4725 21 a a DT cord-335975-m6lkrehi 4725 22 50-bed 50-bed CD cord-335975-m6lkrehi 4725 23 mixed mixed JJ cord-335975-m6lkrehi 4725 24 ICU ICU NNP cord-335975-m6lkrehi 4725 25 of of IN cord-335975-m6lkrehi 4725 26 a a DT cord-335975-m6lkrehi 4725 27 tertiary tertiary JJ cord-335975-m6lkrehi 4725 28 university university NN cord-335975-m6lkrehi 4725 29 teaching teaching NN cord-335975-m6lkrehi 4725 30 hospital hospital NN cord-335975-m6lkrehi 4725 31 , , , cord-335975-m6lkrehi 4725 32 between between IN cord-335975-m6lkrehi 4725 33 January January NNP cord-335975-m6lkrehi 4725 34 1 1 CD cord-335975-m6lkrehi 4725 35 and and CC cord-335975-m6lkrehi 4725 36 December December NNP cord-335975-m6lkrehi 4725 37 31 31 CD cord-335975-m6lkrehi 4725 38 , , , cord-335975-m6lkrehi 4725 39 2016 2016 CD cord-335975-m6lkrehi 4725 40 . . . cord-335975-m6lkrehi 4726 1 VAT VAT NNP cord-335975-m6lkrehi 4726 2 and and CC cord-335975-m6lkrehi 4726 3 VAP VAP NNP cord-335975-m6lkrehi 4726 4 episodes episode NNS cord-335975-m6lkrehi 4726 5 were be VBD cord-335975-m6lkrehi 4726 6 assessed assess VBN cord-335975-m6lkrehi 4726 7 by by IN cord-335975-m6lkrehi 4726 8 prospective prospective JJ cord-335975-m6lkrehi 4726 9 surveillance surveillance NN cord-335975-m6lkrehi 4726 10 of of IN cord-335975-m6lkrehi 4726 11 nosocomial nosocomial JJ cord-335975-m6lkrehi 4726 12 infections infection NNS cord-335975-m6lkrehi 4726 13 , , , cord-335975-m6lkrehi 4726 14 according accord VBG cord-335975-m6lkrehi 4726 15 to to IN cord-335975-m6lkrehi 4726 16 the the DT cord-335975-m6lkrehi 4726 17 American American NNP cord-335975-m6lkrehi 4726 18 Thoracic Thoracic NNP cord-335975-m6lkrehi 4726 19 Society Society NNP cord-335975-m6lkrehi 4726 20 criteria criterion NNS cord-335975-m6lkrehi 4726 21 . . . cord-335975-m6lkrehi 4727 1 VAE VAE NNP cord-335975-m6lkrehi 4727 2 were be VBD cord-335975-m6lkrehi 4727 3 identified identify VBN cord-335975-m6lkrehi 4727 4 retrospectively retrospectively RB cord-335975-m6lkrehi 4727 5 , , , cord-335975-m6lkrehi 4727 6 according accord VBG cord-335975-m6lkrehi 4727 7 to to IN cord-335975-m6lkrehi 4727 8 current current JJ cord-335975-m6lkrehi 4727 9 CDC CDC NNP cord-335975-m6lkrehi 4727 10 definitions definition NNS cord-335975-m6lkrehi 4727 11 . . . cord-335975-m6lkrehi 4728 1 The the DT cord-335975-m6lkrehi 4728 2 agreement agreement NN cord-335975-m6lkrehi 4728 3 between between IN cord-335975-m6lkrehi 4728 4 VAC vac NN cord-335975-m6lkrehi 4728 5 , , , cord-335975-m6lkrehi 4728 6 IVAC IVAC NNP cord-335975-m6lkrehi 4728 7 , , , cord-335975-m6lkrehi 4728 8 PVAP PVAP NNP cord-335975-m6lkrehi 4728 9 and and CC cord-335975-m6lkrehi 4728 10 VALRTI VALRTI NNP cord-335975-m6lkrehi 4728 11 was be VBD cord-335975-m6lkrehi 4728 12 assessed assess VBN cord-335975-m6lkrehi 4728 13 by by IN cord-335975-m6lkrehi 4728 14 k k NNP cord-335975-m6lkrehi 4728 15 statistic statistic NN cord-335975-m6lkrehi 4728 16 . . . cord-335975-m6lkrehi 4729 1 The the DT cord-335975-m6lkrehi 4729 2 impact impact NN cord-335975-m6lkrehi 4729 3 of of IN cord-335975-m6lkrehi 4729 4 VAE VAE NNP cord-335975-m6lkrehi 4729 5 and and CC cord-335975-m6lkrehi 4729 6 VALRTI VALRTI NNS cord-335975-m6lkrehi 4729 7 on on IN cord-335975-m6lkrehi 4729 8 duration duration NN cord-335975-m6lkrehi 4729 9 of of IN cord-335975-m6lkrehi 4729 10 mechanical mechanical JJ cord-335975-m6lkrehi 4729 11 ventilation ventilation NN cord-335975-m6lkrehi 4729 12 , , , cord-335975-m6lkrehi 4729 13 ICU ICU NNP cord-335975-m6lkrehi 4729 14 and and CC cord-335975-m6lkrehi 4729 15 hospital hospital NN cord-335975-m6lkrehi 4729 16 length length NN cord-335975-m6lkrehi 4729 17 of of IN cord-335975-m6lkrehi 4729 18 stay stay NN cord-335975-m6lkrehi 4729 19 and and CC cord-335975-m6lkrehi 4729 20 mortality mortality NN cord-335975-m6lkrehi 4729 21 was be VBD cord-335975-m6lkrehi 4729 22 also also RB cord-335975-m6lkrehi 4729 23 assessed assess VBN cord-335975-m6lkrehi 4729 24 for for IN cord-335975-m6lkrehi 4729 25 the the DT cord-335975-m6lkrehi 4729 26 first first JJ cord-335975-m6lkrehi 4729 27 episode episode NN cord-335975-m6lkrehi 4729 28 of of IN cord-335975-m6lkrehi 4729 29 VAT VAT NNP cord-335975-m6lkrehi 4729 30 and and CC cord-335975-m6lkrehi 4729 31 VAP VAP NNP cord-335975-m6lkrehi 4729 32 . . . cord-335975-m6lkrehi 4730 1 Results result NNS cord-335975-m6lkrehi 4730 2 : : : cord-335975-m6lkrehi 4731 1 We -PRON- PRP cord-335975-m6lkrehi 4731 2 included include VBD cord-335975-m6lkrehi 4731 3 545 545 CD cord-335975-m6lkrehi 4731 4 patients patient NNS cord-335975-m6lkrehi 4731 5 ( ( -LRB- cord-335975-m6lkrehi 4731 6 7927 7927 CD cord-335975-m6lkrehi 4731 7 ventilator ventilator NN cord-335975-m6lkrehi 4731 8 days day NNS cord-335975-m6lkrehi 4731 9 ) ) -RRB- cord-335975-m6lkrehi 4731 10 . . . cord-335975-m6lkrehi 4732 1 126 126 CD cord-335975-m6lkrehi 4732 2 VAP VAP NNP cord-335975-m6lkrehi 4732 3 ( ( -LRB- cord-335975-m6lkrehi 4732 4 15.9 15.9 CD cord-335975-m6lkrehi 4732 5 per per IN cord-335975-m6lkrehi 4732 6 1000 1000 CD cord-335975-m6lkrehi 4732 7 ventilator ventilator NN cord-335975-m6lkrehi 4732 8 - - HYPH cord-335975-m6lkrehi 4732 9 days day NNS cord-335975-m6lkrehi 4732 10 ) ) -RRB- cord-335975-m6lkrehi 4732 11 , , , cord-335975-m6lkrehi 4732 12 80 80 CD cord-335975-m6lkrehi 4732 13 VAT vat NN cord-335975-m6lkrehi 4732 14 ( ( -LRB- cord-335975-m6lkrehi 4732 15 10.1 10.1 CD cord-335975-m6lkrehi 4732 16 per per IN cord-335975-m6lkrehi 4732 17 1000 1000 CD cord-335975-m6lkrehi 4732 18 ventilator ventilator NN cord-335975-m6lkrehi 4732 19 - - HYPH cord-335975-m6lkrehi 4732 20 days day NNS cord-335975-m6lkrehi 4732 21 ) ) -RRB- cord-335975-m6lkrehi 4732 22 and and CC cord-335975-m6lkrehi 4732 23 115 115 CD cord-335975-m6lkrehi 4732 24 VAE VAE NNP cord-335975-m6lkrehi 4732 25 ( ( -LRB- cord-335975-m6lkrehi 4732 26 14.5 14.5 CD cord-335975-m6lkrehi 4732 27 per per IN cord-335975-m6lkrehi 4732 28 1000 1000 CD cord-335975-m6lkrehi 4732 29 ventilator ventilator NN cord-335975-m6lkrehi 4732 30 - - HYPH cord-335975-m6lkrehi 4732 31 days day NNS cord-335975-m6lkrehi 4732 32 ) ) -RRB- cord-335975-m6lkrehi 4732 33 were be VBD cord-335975-m6lkrehi 4732 34 diagnosed diagnose VBN cord-335975-m6lkrehi 4732 35 . . . cord-335975-m6lkrehi 4733 1 There there EX cord-335975-m6lkrehi 4733 2 was be VBD cord-335975-m6lkrehi 4733 3 no no DT cord-335975-m6lkrehi 4733 4 agreement agreement NN cord-335975-m6lkrehi 4733 5 between between IN cord-335975-m6lkrehi 4733 6 VAT vat NN cord-335975-m6lkrehi 4733 7 and and CC cord-335975-m6lkrehi 4733 8 VAE VAE NNP cord-335975-m6lkrehi 4733 9 and and CC cord-335975-m6lkrehi 4733 10 the the DT cord-335975-m6lkrehi 4733 11 agreement agreement NN cord-335975-m6lkrehi 4733 12 was be VBD cord-335975-m6lkrehi 4733 13 poor poor JJ cord-335975-m6lkrehi 4733 14 between between IN cord-335975-m6lkrehi 4733 15 VAP VAP NNP cord-335975-m6lkrehi 4733 16 and and CC cord-335975-m6lkrehi 4733 17 VAC VAC NNP cord-335975-m6lkrehi 4733 18 ( ( -LRB- cord-335975-m6lkrehi 4733 19 k k NN cord-335975-m6lkrehi 4733 20 = = SYM cord-335975-m6lkrehi 4733 21 0.12 0.12 CD cord-335975-m6lkrehi 4733 22 , , , cord-335975-m6lkrehi 4733 23 95 95 CD cord-335975-m6lkrehi 4733 24 % % NN cord-335975-m6lkrehi 4733 25 CI CI NNP cord-335975-m6lkrehi 4733 26 0.03 0.03 CD cord-335975-m6lkrehi 4733 27 - - HYPH cord-335975-m6lkrehi 4733 28 0.20 0.20 CD cord-335975-m6lkrehi 4733 29 ) ) -RRB- cord-335975-m6lkrehi 4733 30 , , , cord-335975-m6lkrehi 4733 31 VAP VAP NNP cord-335975-m6lkrehi 4733 32 and and CC cord-335975-m6lkrehi 4733 33 IVAC IVAC NNP cord-335975-m6lkrehi 4733 34 ( ( -LRB- cord-335975-m6lkrehi 4733 35 k k NN cord-335975-m6lkrehi 4733 36 = = SYM cord-335975-m6lkrehi 4733 37 0.23 0.23 CD cord-335975-m6lkrehi 4733 38 , , , cord-335975-m6lkrehi 4733 39 95 95 CD cord-335975-m6lkrehi 4733 40 % % NN cord-335975-m6lkrehi 4733 41 CI CI NNP cord-335975-m6lkrehi 4733 42 0.14 0.14 CD cord-335975-m6lkrehi 4733 43 - - HYPH cord-335975-m6lkrehi 4733 44 0.32 0.32 CD cord-335975-m6lkrehi 4733 45 ) ) -RRB- cord-335975-m6lkrehi 4733 46 or or CC cord-335975-m6lkrehi 4733 47 VAP VAP NNP cord-335975-m6lkrehi 4733 48 and and CC cord-335975-m6lkrehi 4733 49 PVAP PVAP NNP cord-335975-m6lkrehi 4733 50 ( ( -LRB- cord-335975-m6lkrehi 4733 51 k k NN cord-335975-m6lkrehi 4733 52 = = SYM cord-335975-m6lkrehi 4733 53 0.30 0.30 CD cord-335975-m6lkrehi 4733 54 , , , cord-335975-m6lkrehi 4733 55 95 95 CD cord-335975-m6lkrehi 4733 56 % % NN cord-335975-m6lkrehi 4733 57 CI CI NNP cord-335975-m6lkrehi 4733 58 0.22 0.22 CD cord-335975-m6lkrehi 4733 59 - - HYPH cord-335975-m6lkrehi 4733 60 0.40 0.40 CD cord-335975-m6lkrehi 4733 61 ) ) -RRB- cord-335975-m6lkrehi 4733 62 . . . cord-335975-m6lkrehi 4734 1 Patients patient NNS cord-335975-m6lkrehi 4734 2 who who WP cord-335975-m6lkrehi 4734 3 developed develop VBD cord-335975-m6lkrehi 4734 4 VAT vat NN cord-335975-m6lkrehi 4734 5 , , , cord-335975-m6lkrehi 4734 6 VAP VAP NNP cord-335975-m6lkrehi 4734 7 or or CC cord-335975-m6lkrehi 4734 8 VAE VAE NNP cord-335975-m6lkrehi 4734 9 had have VBD cord-335975-m6lkrehi 4734 10 significantly significantly RB cord-335975-m6lkrehi 4734 11 longer long JJR cord-335975-m6lkrehi 4734 12 duration duration NN cord-335975-m6lkrehi 4734 13 of of IN cord-335975-m6lkrehi 4734 14 mechanical mechanical JJ cord-335975-m6lkrehi 4734 15 ventilation ventilation NN cord-335975-m6lkrehi 4734 16 , , , cord-335975-m6lkrehi 4734 17 ICU ICU NNP cord-335975-m6lkrehi 4734 18 and and CC cord-335975-m6lkrehi 4734 19 hospital hospital NN cord-335975-m6lkrehi 4734 20 length length NN cord-335975-m6lkrehi 4734 21 of of IN cord-335975-m6lkrehi 4734 22 stay stay NN cord-335975-m6lkrehi 4734 23 , , , cord-335975-m6lkrehi 4734 24 compared compare VBN cord-335975-m6lkrehi 4734 25 to to IN cord-335975-m6lkrehi 4734 26 patients patient NNS cord-335975-m6lkrehi 4734 27 who who WP cord-335975-m6lkrehi 4734 28 did do VBD cord-335975-m6lkrehi 4734 29 not not RB cord-335975-m6lkrehi 4734 30 , , , cord-335975-m6lkrehi 4734 31 with with IN cord-335975-m6lkrehi 4734 32 similar similar JJ cord-335975-m6lkrehi 4734 33 mortality mortality NN cord-335975-m6lkrehi 4734 34 rates rate NNS cord-335975-m6lkrehi 4734 35 . . . cord-335975-m6lkrehi 4735 1 Conclusion conclusion NN cord-335975-m6lkrehi 4735 2 : : : cord-335975-m6lkrehi 4735 3 VAE VAE NNP cord-335975-m6lkrehi 4735 4 are be VBP cord-335975-m6lkrehi 4735 5 not not RB cord-335975-m6lkrehi 4735 6 relevant relevant JJ cord-335975-m6lkrehi 4735 7 for for IN cord-335975-m6lkrehi 4735 8 VAT vat NN cord-335975-m6lkrehi 4735 9 diagnosis diagnosis NN cord-335975-m6lkrehi 4735 10 and and CC cord-335975-m6lkrehi 4735 11 have have VBP cord-335975-m6lkrehi 4735 12 low low JJ cord-335975-m6lkrehi 4735 13 agreement agreement NN cord-335975-m6lkrehi 4735 14 with with IN cord-335975-m6lkrehi 4735 15 VAP VAP NNP cord-335975-m6lkrehi 4735 16 , , , cord-335975-m6lkrehi 4735 17 despite despite IN cord-335975-m6lkrehi 4735 18 their -PRON- PRP$ cord-335975-m6lkrehi 4735 19 negative negative JJ cord-335975-m6lkrehi 4735 20 impact impact NN cord-335975-m6lkrehi 4735 21 on on IN cord-335975-m6lkrehi 4735 22 ventilation ventilation NN cord-335975-m6lkrehi 4735 23 duration duration NN cord-335975-m6lkrehi 4735 24 , , , cord-335975-m6lkrehi 4735 25 ICU ICU NNP cord-335975-m6lkrehi 4735 26 and and CC cord-335975-m6lkrehi 4735 27 hospital hospital NN cord-335975-m6lkrehi 4735 28 length length NN cord-335975-m6lkrehi 4735 29 of of IN cord-335975-m6lkrehi 4735 30 stay stay NN cord-335975-m6lkrehi 4735 31 ( ( -LRB- cord-335975-m6lkrehi 4735 32 Fig fig NN cord-335975-m6lkrehi 4735 33 . . . cord-335975-m6lkrehi 4735 34 1 1 CD cord-335975-m6lkrehi 4735 35 ) ) -RRB- cord-335975-m6lkrehi 4735 36 . . . cord-335975-m6lkrehi 4736 1 The the DT cord-335975-m6lkrehi 4736 2 Introduction introduction NN cord-335975-m6lkrehi 4736 3 : : : cord-335975-m6lkrehi 4736 4 Post Post NNP cord-335975-m6lkrehi 4736 5 - - JJ cord-335975-m6lkrehi 4736 6 Operative operative JJ cord-335975-m6lkrehi 4736 7 Pneumonia Pneumonia NNP cord-335975-m6lkrehi 4736 8 ( ( -LRB- cord-335975-m6lkrehi 4736 9 POP pop NN cord-335975-m6lkrehi 4736 10 ) ) -RRB- cord-335975-m6lkrehi 4736 11 is be VBZ cord-335975-m6lkrehi 4736 12 a a DT cord-335975-m6lkrehi 4736 13 frequent frequent JJ cord-335975-m6lkrehi 4736 14 and and CC cord-335975-m6lkrehi 4736 15 severe severe JJ cord-335975-m6lkrehi 4736 16 complication complication NN cord-335975-m6lkrehi 4736 17 of of IN cord-335975-m6lkrehi 4736 18 major major JJ cord-335975-m6lkrehi 4736 19 lung lung NN cord-335975-m6lkrehi 4736 20 resection resection NN cord-335975-m6lkrehi 4736 21 surgery surgery NN cord-335975-m6lkrehi 4736 22 . . . cord-335975-m6lkrehi 4737 1 In in IN cord-335975-m6lkrehi 4737 2 2002 2002 CD cord-335975-m6lkrehi 4737 3 , , , cord-335975-m6lkrehi 4737 4 we -PRON- PRP cord-335975-m6lkrehi 4737 5 changed change VBD cord-335975-m6lkrehi 4737 6 our -PRON- PRP$ cord-335975-m6lkrehi 4737 7 surgical surgical JJ cord-335975-m6lkrehi 4737 8 antibioprophylaxis antibioprophylaxis NN cord-335975-m6lkrehi 4737 9 protocol protocol NN cord-335975-m6lkrehi 4737 10 from from IN cord-335975-m6lkrehi 4737 11 cefamandole cefamandole NN cord-335975-m6lkrehi 4737 12 to to IN cord-335975-m6lkrehi 4737 13 amoxicillin amoxicillin NNP cord-335975-m6lkrehi 4737 14 - - HYPH cord-335975-m6lkrehi 4737 15 clavulanate clavulanate NNP cord-335975-m6lkrehi 4737 16 and and CC cord-335975-m6lkrehi 4737 17 observed observe VBD cord-335975-m6lkrehi 4737 18 a a DT cord-335975-m6lkrehi 4737 19 significant significant JJ cord-335975-m6lkrehi 4737 20 decrease decrease NN cord-335975-m6lkrehi 4737 21 of of IN cord-335975-m6lkrehi 4737 22 POP pop NN cord-335975-m6lkrehi 4737 23 incidence incidence NN cord-335975-m6lkrehi 4737 24 and and CC cord-335975-m6lkrehi 4737 25 mortality mortality NN cord-335975-m6lkrehi 4737 26 . . . cord-335975-m6lkrehi 4738 1 In in IN cord-335975-m6lkrehi 4738 2 2012 2012 CD cord-335975-m6lkrehi 4738 3 , , , cord-335975-m6lkrehi 4738 4 we -PRON- PRP cord-335975-m6lkrehi 4738 5 additionally additionally RB cord-335975-m6lkrehi 4738 6 implemented implement VBD cord-335975-m6lkrehi 4738 7 in in IN cord-335975-m6lkrehi 4738 8 the the DT cord-335975-m6lkrehi 4738 9 respiratory respiratory JJ cord-335975-m6lkrehi 4738 10 intensive intensive JJ cord-335975-m6lkrehi 4738 11 care care NN cord-335975-m6lkrehi 4738 12 unit unit NN cord-335975-m6lkrehi 4738 13 ( ( -LRB- cord-335975-m6lkrehi 4738 14 RICU RICU NNP cord-335975-m6lkrehi 4738 15 ) ) -RRB- cord-335975-m6lkrehi 4738 16 an an DT cord-335975-m6lkrehi 4738 17 antimicrobial antimicrobial JJ cord-335975-m6lkrehi 4738 18 stewardship stewardship NN cord-335975-m6lkrehi 4738 19 program program NN cord-335975-m6lkrehi 4738 20 based base VBN cord-335975-m6lkrehi 4738 21 on on IN cord-335975-m6lkrehi 4738 22 a a DT cord-335975-m6lkrehi 4738 23 local local JJ cord-335975-m6lkrehi 4738 24 antimicrobial antimicrobial JJ cord-335975-m6lkrehi 4738 25 guideline guideline NN cord-335975-m6lkrehi 4738 26 and and CC cord-335975-m6lkrehi 4738 27 a a DT cord-335975-m6lkrehi 4738 28 weekly weekly JJ cord-335975-m6lkrehi 4738 29 multidisciplinary multidisciplinary JJ cord-335975-m6lkrehi 4738 30 review review NN cord-335975-m6lkrehi 4738 31 of of IN cord-335975-m6lkrehi 4738 32 all all DT cord-335975-m6lkrehi 4738 33 antibiotic antibiotic JJ cord-335975-m6lkrehi 4738 34 therapies therapy NNS cord-335975-m6lkrehi 4738 35 by by IN cord-335975-m6lkrehi 4738 36 RICU RICU NNP cord-335975-m6lkrehi 4738 37 physicians physician NNS cord-335975-m6lkrehi 4738 38 , , , cord-335975-m6lkrehi 4738 39 infectious infectious JJ cord-335975-m6lkrehi 4738 40 diseases disease NNS cord-335975-m6lkrehi 4738 41 specialists specialist NNS cord-335975-m6lkrehi 4738 42 and and CC cord-335975-m6lkrehi 4738 43 microbiologists microbiologist NNS cord-335975-m6lkrehi 4738 44 . . . cord-335975-m6lkrehi 4739 1 Our -PRON- PRP$ cord-335975-m6lkrehi 4739 2 objectives objective NNS cord-335975-m6lkrehi 4739 3 were be VBD cord-335975-m6lkrehi 4739 4 to to TO cord-335975-m6lkrehi 4739 5 describe describe VB cord-335975-m6lkrehi 4739 6 our -PRON- PRP$ cord-335975-m6lkrehi 4739 7 current current JJ cord-335975-m6lkrehi 4739 8 epidemiology epidemiology NN cord-335975-m6lkrehi 4739 9 of of IN cord-335975-m6lkrehi 4739 10 severe severe JJ cord-335975-m6lkrehi 4739 11 POP pop NN cord-335975-m6lkrehi 4739 12 and and CC cord-335975-m6lkrehi 4739 13 to to TO cord-335975-m6lkrehi 4739 14 assess assess VB cord-335975-m6lkrehi 4739 15 the the DT cord-335975-m6lkrehi 4739 16 quality quality NN cord-335975-m6lkrehi 4739 17 of of IN cord-335975-m6lkrehi 4739 18 antibiotic antibiotic JJ cord-335975-m6lkrehi 4739 19 prescriptions prescription NNS cord-335975-m6lkrehi 4739 20 . . . cord-335975-m6lkrehi 4740 1 Patients patient NNS cord-335975-m6lkrehi 4740 2 and and CC cord-335975-m6lkrehi 4740 3 methods method NNS cord-335975-m6lkrehi 4740 4 : : : cord-335975-m6lkrehi 4740 5 All all DT cord-335975-m6lkrehi 4740 6 patients patient NNS cord-335975-m6lkrehi 4740 7 with with IN cord-335975-m6lkrehi 4740 8 severe severe JJ cord-335975-m6lkrehi 4740 9 POP pop NN cord-335975-m6lkrehi 4740 10 occurring occur VBG cord-335975-m6lkrehi 4740 11 within within IN cord-335975-m6lkrehi 4740 12 30 30 CD cord-335975-m6lkrehi 4740 13 days day NNS cord-335975-m6lkrehi 4740 14 after after IN cord-335975-m6lkrehi 4740 15 lung lung NN cord-335975-m6lkrehi 4740 16 resection resection NN cord-335975-m6lkrehi 4740 17 between between IN cord-335975-m6lkrehi 4740 18 January January NNP cord-335975-m6lkrehi 4740 19 2013 2013 CD cord-335975-m6lkrehi 4740 20 and and CC cord-335975-m6lkrehi 4740 21 December December NNP cord-335975-m6lkrehi 4740 22 2015 2015 CD cord-335975-m6lkrehi 4740 23 were be VBD cord-335975-m6lkrehi 4740 24 included include VBN cord-335975-m6lkrehi 4740 25 . . . cord-335975-m6lkrehi 4741 1 We -PRON- PRP cord-335975-m6lkrehi 4741 2 collected collect VBD cord-335975-m6lkrehi 4741 3 data datum NNS cord-335975-m6lkrehi 4741 4 on on IN cord-335975-m6lkrehi 4741 5 clinical clinical JJ cord-335975-m6lkrehi 4741 6 presentation presentation NN cord-335975-m6lkrehi 4741 7 , , , cord-335975-m6lkrehi 4741 8 results result NNS cord-335975-m6lkrehi 4741 9 of of IN cord-335975-m6lkrehi 4741 10 microbiological microbiological JJ cord-335975-m6lkrehi 4741 11 investigations investigation NNS cord-335975-m6lkrehi 4741 12 , , , cord-335975-m6lkrehi 4741 13 antibiotic antibiotic JJ cord-335975-m6lkrehi 4741 14 regimen regimen NN cord-335975-m6lkrehi 4741 15 and and CC cord-335975-m6lkrehi 4741 16 outcomes outcome NNS cord-335975-m6lkrehi 4741 17 . . . cord-335975-m6lkrehi 4742 1 The the DT cord-335975-m6lkrehi 4742 2 quality quality NN cord-335975-m6lkrehi 4742 3 of of IN cord-335975-m6lkrehi 4742 4 antibiotic antibiotic JJ cord-335975-m6lkrehi 4742 5 use use NN cord-335975-m6lkrehi 4742 6 was be VBD cord-335975-m6lkrehi 4742 7 assessed assess VBN cord-335975-m6lkrehi 4742 8 using use VBG cord-335975-m6lkrehi 4742 9 indicators indicator NNS cord-335975-m6lkrehi 4742 10 previously previously RB cord-335975-m6lkrehi 4742 11 validated validate VBN cord-335975-m6lkrehi 4742 12 in in IN cord-335975-m6lkrehi 4742 13 the the DT cord-335975-m6lkrehi 4742 14 literature literature NN cord-335975-m6lkrehi 4742 15 . . . cord-335975-m6lkrehi 4743 1 Results result NNS cord-335975-m6lkrehi 4743 2 : : : cord-335975-m6lkrehi 4744 1 Over over IN cord-335975-m6lkrehi 4744 2 1555 1555 CD cord-335975-m6lkrehi 4744 3 patients patient NNS cord-335975-m6lkrehi 4744 4 who who WP cord-335975-m6lkrehi 4744 5 underwent undergo VBD cord-335975-m6lkrehi 4744 6 major major JJ cord-335975-m6lkrehi 4744 7 lung lung NN cord-335975-m6lkrehi 4744 8 resection resection NN cord-335975-m6lkrehi 4744 9 in in IN cord-335975-m6lkrehi 4744 10 our -PRON- PRP$ cord-335975-m6lkrehi 4744 11 center center NN cord-335975-m6lkrehi 4744 12 , , , cord-335975-m6lkrehi 4744 13 91 91 CD cord-335975-m6lkrehi 4744 14 matched match VBD cord-335975-m6lkrehi 4744 15 criteria criterion NNS cord-335975-m6lkrehi 4744 16 for for IN cord-335975-m6lkrehi 4744 17 severe severe JJ cord-335975-m6lkrehi 4744 18 POP pop NN cord-335975-m6lkrehi 4744 19 and and CC cord-335975-m6lkrehi 4744 20 were be VBD cord-335975-m6lkrehi 4744 21 included include VBN cord-335975-m6lkrehi 4744 22 . . . cord-335975-m6lkrehi 4745 1 Most Most JJS cord-335975-m6lkrehi 4745 2 were be VBD cord-335975-m6lkrehi 4745 3 males male NNS cord-335975-m6lkrehi 4745 4 ( ( -LRB- cord-335975-m6lkrehi 4745 5 n n NN cord-335975-m6lkrehi 4745 6 = = SYM cord-335975-m6lkrehi 4745 7 71 71 CD cord-335975-m6lkrehi 4745 8 , , , cord-335975-m6lkrehi 4745 9 78 78 CD cord-335975-m6lkrehi 4745 10 % % NN cord-335975-m6lkrehi 4745 11 ) ) -RRB- cord-335975-m6lkrehi 4745 12 . . . cord-335975-m6lkrehi 4746 1 The the DT cord-335975-m6lkrehi 4746 2 median median JJ cord-335975-m6lkrehi 4746 3 age age NN cord-335975-m6lkrehi 4746 4 was be VBD cord-335975-m6lkrehi 4746 5 69 69 CD cord-335975-m6lkrehi 4746 6 years year NNS cord-335975-m6lkrehi 4746 7 ( ( -LRB- cord-335975-m6lkrehi 4746 8 minimum-42 minimum-42 NNP cord-335975-m6lkrehi 4746 9 + + SYM cord-335975-m6lkrehi 4746 10 maximum-84 maximum-84 NNP cord-335975-m6lkrehi 4746 11 ) ) -RRB- cord-335975-m6lkrehi 4746 12 . . . cord-335975-m6lkrehi 4747 1 Most Most JJS cord-335975-m6lkrehi 4747 2 patients patient NNS cord-335975-m6lkrehi 4747 3 had have VBD cord-335975-m6lkrehi 4747 4 chronic chronic JJ cord-335975-m6lkrehi 4747 5 obstructive obstructive JJ cord-335975-m6lkrehi 4747 6 pulmonary pulmonary JJ cord-335975-m6lkrehi 4747 7 disease disease NN cord-335975-m6lkrehi 4747 8 ( ( -LRB- cord-335975-m6lkrehi 4747 9 n n NN cord-335975-m6lkrehi 4747 10 = = SYM cord-335975-m6lkrehi 4747 11 59 59 CD cord-335975-m6lkrehi 4747 12 , , , cord-335975-m6lkrehi 4747 13 65 65 CD cord-335975-m6lkrehi 4747 14 % % NN cord-335975-m6lkrehi 4747 15 ) ) -RRB- cord-335975-m6lkrehi 4747 16 and and CC cord-335975-m6lkrehi 4747 17 18 18 CD cord-335975-m6lkrehi 4747 18 ( ( -LRB- cord-335975-m6lkrehi 4747 19 20 20 CD cord-335975-m6lkrehi 4747 20 % % NN cord-335975-m6lkrehi 4747 21 ) ) -RRB- cord-335975-m6lkrehi 4748 1 a a DT cord-335975-m6lkrehi 4748 2 history history NN cord-335975-m6lkrehi 4748 3 of of IN cord-335975-m6lkrehi 4748 4 non non JJ cord-335975-m6lkrehi 4748 5 - - JJ cord-335975-m6lkrehi 4748 6 pulmonary pulmonary JJ cord-335975-m6lkrehi 4748 7 cancer cancer NN cord-335975-m6lkrehi 4748 8 . . . cord-335975-m6lkrehi 4749 1 The the DT cord-335975-m6lkrehi 4749 2 resection resection NN cord-335975-m6lkrehi 4749 3 consisted consist VBD cord-335975-m6lkrehi 4749 4 in in IN cord-335975-m6lkrehi 4749 5 lobectomy lobectomy NN cord-335975-m6lkrehi 4749 6 in in IN cord-335975-m6lkrehi 4749 7 59 59 CD cord-335975-m6lkrehi 4749 8 % % NN cord-335975-m6lkrehi 4749 9 ( ( -LRB- cord-335975-m6lkrehi 4749 10 n n NN cord-335975-m6lkrehi 4749 11 = = SYM cord-335975-m6lkrehi 4749 12 54 54 CD cord-335975-m6lkrehi 4749 13 ) ) -RRB- cord-335975-m6lkrehi 4749 14 . . . cord-335975-m6lkrehi 4750 1 The the DT cord-335975-m6lkrehi 4750 2 median median JJ cord-335975-m6lkrehi 4750 3 length length NN cord-335975-m6lkrehi 4750 4 of of IN cord-335975-m6lkrehi 4750 5 stay stay NN cord-335975-m6lkrehi 4750 6 in in IN cord-335975-m6lkrehi 4750 7 RICU RICU NNP cord-335975-m6lkrehi 4750 8 was be VBD cord-335975-m6lkrehi 4750 9 12 12 CD cord-335975-m6lkrehi 4750 10 days day NNS cord-335975-m6lkrehi 4750 11 ( ( -LRB- cord-335975-m6lkrehi 4750 12 1 1 CD cord-335975-m6lkrehi 4750 13 + + SYM cord-335975-m6lkrehi 4750 14 90 90 CD cord-335975-m6lkrehi 4750 15 ) ) -RRB- cord-335975-m6lkrehi 4750 16 , , , cord-335975-m6lkrehi 4750 17 and and CC cord-335975-m6lkrehi 4750 18 30-day 30-day CD cord-335975-m6lkrehi 4750 19 mortality mortality NN cord-335975-m6lkrehi 4750 20 was be VBD cord-335975-m6lkrehi 4750 21 9 9 CD cord-335975-m6lkrehi 4750 22 % % NN cord-335975-m6lkrehi 4750 23 ( ( -LRB- cord-335975-m6lkrehi 4750 24 n n NN cord-335975-m6lkrehi 4750 25 = = SYM cord-335975-m6lkrehi 4750 26 8) 8) NN cord-335975-m6lkrehi 4750 27 . . . cord-335975-m6lkrehi 4751 1 Respiratory respiratory JJ cord-335975-m6lkrehi 4751 2 microbiological microbiological JJ cord-335975-m6lkrehi 4751 3 samples sample NNS cord-335975-m6lkrehi 4751 4 were be VBD cord-335975-m6lkrehi 4751 5 obtained obtain VBN cord-335975-m6lkrehi 4751 6 in in IN cord-335975-m6lkrehi 4751 7 all all DT cord-335975-m6lkrehi 4751 8 patients patient NNS cord-335975-m6lkrehi 4751 9 , , , cord-335975-m6lkrehi 4751 10 in in IN cord-335975-m6lkrehi 4751 11 most most JJS cord-335975-m6lkrehi 4751 12 cases case NNS cord-335975-m6lkrehi 4751 13 invasively invasively RB cord-335975-m6lkrehi 4751 14 per per IN cord-335975-m6lkrehi 4751 15 bronchoscopy bronchoscopy NN cord-335975-m6lkrehi 4751 16 ( ( -LRB- cord-335975-m6lkrehi 4751 17 74 74 CD cord-335975-m6lkrehi 4751 18 % % NN cord-335975-m6lkrehi 4751 19 ) ) -RRB- cord-335975-m6lkrehi 4751 20 . . . cord-335975-m6lkrehi 4752 1 Microorganisms microorganism NNS cord-335975-m6lkrehi 4752 2 were be VBD cord-335975-m6lkrehi 4752 3 cultured culture VBN cord-335975-m6lkrehi 4752 4 at at IN cord-335975-m6lkrehi 4752 5 a a DT cord-335975-m6lkrehi 4752 6 significant significant JJ cord-335975-m6lkrehi 4752 7 level level NN cord-335975-m6lkrehi 4752 8 in in IN cord-335975-m6lkrehi 4752 9 66 66 CD cord-335975-m6lkrehi 4752 10 ( ( -LRB- cord-335975-m6lkrehi 4752 11 73 73 CD cord-335975-m6lkrehi 4752 12 % % NN cord-335975-m6lkrehi 4752 13 ) ) -RRB- cord-335975-m6lkrehi 4752 14 patients patient NNS cord-335975-m6lkrehi 4752 15 . . . cord-335975-m6lkrehi 4753 1 Predominant predominant JJ cord-335975-m6lkrehi 4753 2 species specie NNS cord-335975-m6lkrehi 4753 3 were be VBD cord-335975-m6lkrehi 4753 4 Enterobacteriacae Enterobacteriacae NNP cord-335975-m6lkrehi 4753 5 ( ( -LRB- cord-335975-m6lkrehi 4753 6 58 58 CD cord-335975-m6lkrehi 4753 7 % % NN cord-335975-m6lkrehi 4753 8 ) ) -RRB- cord-335975-m6lkrehi 4753 9 , , , cord-335975-m6lkrehi 4753 10 Haemophilus haemophilus JJ cord-335975-m6lkrehi 4753 11 influenzae influenzae NN cord-335975-m6lkrehi 4753 12 ( ( -LRB- cord-335975-m6lkrehi 4753 13 14 14 CD cord-335975-m6lkrehi 4753 14 % % NN cord-335975-m6lkrehi 4753 15 ) ) -RRB- cord-335975-m6lkrehi 4753 16 , , , cord-335975-m6lkrehi 4753 17 Staphylococcus Staphylococcus NNP cord-335975-m6lkrehi 4753 18 aureus aureus NN cord-335975-m6lkrehi 4753 19 ( ( -LRB- cord-335975-m6lkrehi 4753 20 11 11 CD cord-335975-m6lkrehi 4753 21 % % NN cord-335975-m6lkrehi 4753 22 ) ) -RRB- cord-335975-m6lkrehi 4753 23 and and CC cord-335975-m6lkrehi 4753 24 Pseudomonas Pseudomonas NNP cord-335975-m6lkrehi 4753 25 aeruginosa aeruginosa NN cord-335975-m6lkrehi 4753 26 ( ( -LRB- cord-335975-m6lkrehi 4753 27 10 10 CD cord-335975-m6lkrehi 4753 28 % % NN cord-335975-m6lkrehi 4753 29 ) ) -RRB- cord-335975-m6lkrehi 4753 30 . . . cord-335975-m6lkrehi 4754 1 Microorganisms microorganism NNS cord-335975-m6lkrehi 4754 2 were be VBD cord-335975-m6lkrehi 4754 3 sensitive sensitive JJ cord-335975-m6lkrehi 4754 4 to to IN cord-335975-m6lkrehi 4754 5 third third JJ cord-335975-m6lkrehi 4754 6 generation generation NN cord-335975-m6lkrehi 4754 7 cephalosporins cephalosporin NNS cord-335975-m6lkrehi 4754 8 in in IN cord-335975-m6lkrehi 4754 9 52 52 CD cord-335975-m6lkrehi 4754 10 ( ( -LRB- cord-335975-m6lkrehi 4754 11 79 79 CD cord-335975-m6lkrehi 4754 12 % % NN cord-335975-m6lkrehi 4754 13 ) ) -RRB- cord-335975-m6lkrehi 4754 14 and and CC cord-335975-m6lkrehi 4754 15 to to IN cord-335975-m6lkrehi 4754 16 piperacillin piperacillin NNP cord-335975-m6lkrehi 4754 17 - - HYPH cord-335975-m6lkrehi 4754 18 tazobactam tazobactam NNS cord-335975-m6lkrehi 4754 19 in in IN cord-335975-m6lkrehi 4754 20 57 57 CD cord-335975-m6lkrehi 4754 21 ( ( -LRB- cord-335975-m6lkrehi 4754 22 86 86 CD cord-335975-m6lkrehi 4754 23 % % NN cord-335975-m6lkrehi 4754 24 ) ) -RRB- cord-335975-m6lkrehi 4754 25 . . . cord-335975-m6lkrehi 4755 1 In in IN cord-335975-m6lkrehi 4755 2 patients patient NNS cord-335975-m6lkrehi 4755 3 treated treat VBN cord-335975-m6lkrehi 4755 4 empirically empirically RB cord-335975-m6lkrehi 4755 5 , , , cord-335975-m6lkrehi 4755 6 antibiotics antibiotic NNS cord-335975-m6lkrehi 4755 7 were be VBD cord-335975-m6lkrehi 4755 8 prescribed prescribe VBN cord-335975-m6lkrehi 4755 9 according accord VBG cord-335975-m6lkrehi 4755 10 to to IN cord-335975-m6lkrehi 4755 11 the the DT cord-335975-m6lkrehi 4755 12 guideline guideline NN cord-335975-m6lkrehi 4755 13 in in IN cord-335975-m6lkrehi 4755 14 80 80 CD cord-335975-m6lkrehi 4755 15 % % NN cord-335975-m6lkrehi 4755 16 ( ( -LRB- cord-335975-m6lkrehi 4755 17 69 69 CD cord-335975-m6lkrehi 4755 18 86 86 CD cord-335975-m6lkrehi 4755 19 ) ) -RRB- cord-335975-m6lkrehi 4755 20 . . . cord-335975-m6lkrehi 4756 1 In in IN cord-335975-m6lkrehi 4756 2 documented document VBN cord-335975-m6lkrehi 4756 3 POP pop NN cord-335975-m6lkrehi 4756 4 , , , cord-335975-m6lkrehi 4756 5 empiric empiric JJ cord-335975-m6lkrehi 4756 6 antibiotics antibiotic NNS cord-335975-m6lkrehi 4756 7 were be VBD cord-335975-m6lkrehi 4756 8 active active JJ cord-335975-m6lkrehi 4756 9 against against IN cord-335975-m6lkrehi 4756 10 documented document VBN cord-335975-m6lkrehi 4756 11 micro micro NNS cord-335975-m6lkrehi 4756 12 - - HYPH cord-335975-m6lkrehi 4756 13 organisms organism NNS cord-335975-m6lkrehi 4756 14 in in IN cord-335975-m6lkrehi 4756 15 53 53 CD cord-335975-m6lkrehi 4756 16 62 62 CD cord-335975-m6lkrehi 4756 17 ( ( -LRB- cord-335975-m6lkrehi 4756 18 86 86 CD cord-335975-m6lkrehi 4756 19 % % NN cord-335975-m6lkrehi 4756 20 ) ) -RRB- cord-335975-m6lkrehi 4756 21 , , , cord-335975-m6lkrehi 4756 22 and and CC cord-335975-m6lkrehi 4756 23 were be VBD cord-335975-m6lkrehi 4756 24 correctly correctly RB cord-335975-m6lkrehi 4756 25 changed change VBN cord-335975-m6lkrehi 4756 26 to to IN cord-335975-m6lkrehi 4756 27 pathogen pathogen NN cord-335975-m6lkrehi 4756 28 - - HYPH cord-335975-m6lkrehi 4756 29 directed direct VBN cord-335975-m6lkrehi 4756 30 therapy therapy NN cord-335975-m6lkrehi 4756 31 in in IN cord-335975-m6lkrehi 4756 32 46 46 CD cord-335975-m6lkrehi 4756 33 62 62 CD cord-335975-m6lkrehi 4756 34 ( ( -LRB- cord-335975-m6lkrehi 4756 35 74 74 CD cord-335975-m6lkrehi 4756 36 % % NN cord-335975-m6lkrehi 4756 37 ) ) -RRB- cord-335975-m6lkrehi 4756 38 . . . cord-335975-m6lkrehi 4757 1 The the DT cord-335975-m6lkrehi 4757 2 median median JJ cord-335975-m6lkrehi 4757 3 duration duration NN cord-335975-m6lkrehi 4757 4 of of IN cord-335975-m6lkrehi 4757 5 antibiotics antibiotic NNS cord-335975-m6lkrehi 4757 6 was be VBD cord-335975-m6lkrehi 4757 7 of of IN cord-335975-m6lkrehi 4757 8 7 7 CD cord-335975-m6lkrehi 4757 9 days day NNS cord-335975-m6lkrehi 4757 10 ( ( -LRB- cord-335975-m6lkrehi 4757 11 2 2 CD cord-335975-m6lkrehi 4757 12 + + SYM cord-335975-m6lkrehi 4757 13 21 21 CD cord-335975-m6lkrehi 4757 14 ) ) -RRB- cord-335975-m6lkrehi 4757 15 . . . cord-335975-m6lkrehi 4758 1 Conclusion conclusion NN cord-335975-m6lkrehi 4758 2 : : : cord-335975-m6lkrehi 4759 1 Ten ten CD cord-335975-m6lkrehi 4759 2 years year NNS cord-335975-m6lkrehi 4759 3 after after IN cord-335975-m6lkrehi 4759 4 implementation implementation NN cord-335975-m6lkrehi 4759 5 of of IN cord-335975-m6lkrehi 4759 6 amoxicillin amoxicillin NNP cord-335975-m6lkrehi 4759 7 - - HYPH cord-335975-m6lkrehi 4759 8 clavulanate clavulanate NNP cord-335975-m6lkrehi 4759 9 as as IN cord-335975-m6lkrehi 4759 10 surgical surgical JJ cord-335975-m6lkrehi 4759 11 antibioprophylaxis antibioprophylaxis NN cord-335975-m6lkrehi 4759 12 , , , cord-335975-m6lkrehi 4759 13 the the DT cord-335975-m6lkrehi 4759 14 proportion proportion NN cord-335975-m6lkrehi 4759 15 of of IN cord-335975-m6lkrehi 4759 16 Enterobacteriacae Enterobacteriacae NNP cord-335975-m6lkrehi 4759 17 increased increase VBD cord-335975-m6lkrehi 4759 18 . . . cord-335975-m6lkrehi 4760 1 The the DT cord-335975-m6lkrehi 4760 2 30-day 30-day CD cord-335975-m6lkrehi 4760 3 postoperative postoperative JJ cord-335975-m6lkrehi 4760 4 mortality mortality NN cord-335975-m6lkrehi 4760 5 rate rate NN cord-335975-m6lkrehi 4760 6 remained remain VBD cord-335975-m6lkrehi 4760 7 below below IN cord-335975-m6lkrehi 4760 8 10 10 CD cord-335975-m6lkrehi 4760 9 % % NN cord-335975-m6lkrehi 4760 10 . . . cord-335975-m6lkrehi 4761 1 We -PRON- PRP cord-335975-m6lkrehi 4761 2 report report VBP cord-335975-m6lkrehi 4761 3 high high JJ cord-335975-m6lkrehi 4761 4 adherence adherence NN cord-335975-m6lkrehi 4761 5 to to IN cord-335975-m6lkrehi 4761 6 the the DT cord-335975-m6lkrehi 4761 7 guideline guideline NN cord-335975-m6lkrehi 4761 8 for for IN cord-335975-m6lkrehi 4761 9 the the DT cord-335975-m6lkrehi 4761 10 choice choice NN cord-335975-m6lkrehi 4761 11 of of IN cord-335975-m6lkrehi 4761 12 empirical empirical JJ cord-335975-m6lkrehi 4761 13 therapy therapy NN cord-335975-m6lkrehi 4761 14 and and CC cord-335975-m6lkrehi 4761 15 treatment treatment NN cord-335975-m6lkrehi 4761 16 duration duration NN cord-335975-m6lkrehi 4761 17 . . . cord-335975-m6lkrehi 4762 1 The the DT cord-335975-m6lkrehi 4762 2 rate rate NN cord-335975-m6lkrehi 4762 3 of of IN cord-335975-m6lkrehi 4762 4 de de NN cord-335975-m6lkrehi 4762 5 - - NN cord-335975-m6lkrehi 4762 6 escalation escalation NN cord-335975-m6lkrehi 4762 7 to to IN cord-335975-m6lkrehi 4762 8 pathogen pathogen NN cord-335975-m6lkrehi 4762 9 - - HYPH cord-335975-m6lkrehi 4762 10 directed direct VBN cord-335975-m6lkrehi 4762 11 therapy therapy NN cord-335975-m6lkrehi 4762 12 could could MD cord-335975-m6lkrehi 4762 13 however however RB cord-335975-m6lkrehi 4762 14 be be VB cord-335975-m6lkrehi 4762 15 improved improve VBN cord-335975-m6lkrehi 4762 16 considering consider VBG cord-335975-m6lkrehi 4762 17 the the DT cord-335975-m6lkrehi 4762 18 high high JJ cord-335975-m6lkrehi 4762 19 rate rate NN cord-335975-m6lkrehi 4762 20 of of IN cord-335975-m6lkrehi 4762 21 bacteriologically bacteriologically RB cord-335975-m6lkrehi 4762 22 - - HYPH cord-335975-m6lkrehi 4762 23 documented document VBN cord-335975-m6lkrehi 4762 24 POP pop NN cord-335975-m6lkrehi 4762 25 . . . cord-335975-m6lkrehi 4763 1 resistance resistance NN cord-335975-m6lkrehi 4763 2 of of IN cord-335975-m6lkrehi 4763 3 PA PA NNP cord-335975-m6lkrehi 4763 4 has have VBZ cord-335975-m6lkrehi 4763 5 reduced reduce VBN cord-335975-m6lkrehi 4763 6 between between IN cord-335975-m6lkrehi 4763 7 both both DT cord-335975-m6lkrehi 4763 8 periods period NNS cord-335975-m6lkrehi 4763 9 from from IN cord-335975-m6lkrehi 4763 10 42 42 CD cord-335975-m6lkrehi 4763 11 % % NN cord-335975-m6lkrehi 4763 12 to to IN cord-335975-m6lkrehi 4763 13 11 11 CD cord-335975-m6lkrehi 4763 14 % % NN cord-335975-m6lkrehi 4763 15 ( ( -LRB- cord-335975-m6lkrehi 4763 16 p p NN cord-335975-m6lkrehi 4763 17 < < XX cord-335975-m6lkrehi 4763 18 0.01 0.01 CD cord-335975-m6lkrehi 4763 19 ) ) -RRB- cord-335975-m6lkrehi 4763 20 for for IN cord-335975-m6lkrehi 4763 21 ceftazidim ceftazidim NNP cord-335975-m6lkrehi 4763 22 , , , cord-335975-m6lkrehi 4763 23 from from IN cord-335975-m6lkrehi 4763 24 74 74 CD cord-335975-m6lkrehi 4763 25 % % NN cord-335975-m6lkrehi 4763 26 to to IN cord-335975-m6lkrehi 4763 27 18 18 CD cord-335975-m6lkrehi 4763 28 % % NN cord-335975-m6lkrehi 4763 29 ( ( -LRB- cord-335975-m6lkrehi 4763 30 p p NN cord-335975-m6lkrehi 4763 31 < < XX cord-335975-m6lkrehi 4763 32 0.01 0.01 CD cord-335975-m6lkrehi 4763 33 ) ) -RRB- cord-335975-m6lkrehi 4763 34 for for IN cord-335975-m6lkrehi 4763 35 cirpofloxacin cirpofloxacin NNS cord-335975-m6lkrehi 4763 36 and and CC cord-335975-m6lkrehi 4763 37 from from IN cord-335975-m6lkrehi 4763 38 38 38 CD cord-335975-m6lkrehi 4763 39 % % NN cord-335975-m6lkrehi 4763 40 to to IN cord-335975-m6lkrehi 4763 41 18 18 CD cord-335975-m6lkrehi 4763 42 % % NN cord-335975-m6lkrehi 4763 43 ( ( -LRB- cord-335975-m6lkrehi 4763 44 p p NN cord-335975-m6lkrehi 4763 45 < < XX cord-335975-m6lkrehi 4763 46 0.01 0.01 CD cord-335975-m6lkrehi 4763 47 ) ) -RRB- cord-335975-m6lkrehi 4763 48 for for IN cord-335975-m6lkrehi 4763 49 imipenem imipenem NNP cord-335975-m6lkrehi 4763 50 . . . cord-335975-m6lkrehi 4764 1 Nevertheless nevertheless RB cord-335975-m6lkrehi 4764 2 , , , cord-335975-m6lkrehi 4764 3 among among IN cord-335975-m6lkrehi 4764 4 the the DT cord-335975-m6lkrehi 4764 5 cases case NNS cord-335975-m6lkrehi 4764 6 , , , cord-335975-m6lkrehi 4764 7 the the DT cord-335975-m6lkrehi 4764 8 P2 P2 NNP cord-335975-m6lkrehi 4764 9 period period NN cord-335975-m6lkrehi 4764 10 did do VBD cord-335975-m6lkrehi 4764 11 not not RB cord-335975-m6lkrehi 4764 12 change change VB cord-335975-m6lkrehi 4764 13 the the DT cord-335975-m6lkrehi 4764 14 risk risk NN cord-335975-m6lkrehi 4764 15 of of IN cord-335975-m6lkrehi 4764 16 developing develop VBG cord-335975-m6lkrehi 4764 17 an an DT cord-335975-m6lkrehi 4764 18 infection infection NN cord-335975-m6lkrehi 4765 1 ( ( -LRB- cord-335975-m6lkrehi 4765 2 RR rr NN cord-335975-m6lkrehi 4765 3 = = SYM cord-335975-m6lkrehi 4765 4 0.77 0.77 CD cord-335975-m6lkrehi 4765 5 , , , cord-335975-m6lkrehi 4765 6 CI CI NNP cord-335975-m6lkrehi 4765 7 95 95 CD cord-335975-m6lkrehi 4765 8 % % NN cord-335975-m6lkrehi 4765 9 0.58 0.58 CD cord-335975-m6lkrehi 4765 10 - - HYPH cord-335975-m6lkrehi 4765 11 1.01 1.01 CD cord-335975-m6lkrehi 4765 12 ) ) -RRB- cord-335975-m6lkrehi 4765 13 , , , cord-335975-m6lkrehi 4765 14 a a DT cord-335975-m6lkrehi 4765 15 VAP VAP NNP cord-335975-m6lkrehi 4765 16 ( ( -LRB- cord-335975-m6lkrehi 4765 17 RR rr NN cord-335975-m6lkrehi 4765 18 = = SYM cord-335975-m6lkrehi 4765 19 0.99 0.99 CD cord-335975-m6lkrehi 4765 20 , , , cord-335975-m6lkrehi 4765 21 CI CI NNP cord-335975-m6lkrehi 4765 22 95 95 CD cord-335975-m6lkrehi 4765 23 % % NN cord-335975-m6lkrehi 4765 24 0.76 0.76 CD cord-335975-m6lkrehi 4765 25 - - HYPH cord-335975-m6lkrehi 4765 26 1.28 1.28 CD cord-335975-m6lkrehi 4765 27 ) ) -RRB- cord-335975-m6lkrehi 4765 28 , , , cord-335975-m6lkrehi 4765 29 a a DT cord-335975-m6lkrehi 4765 30 septicemia septicemia NN cord-335975-m6lkrehi 4765 31 ( ( -LRB- cord-335975-m6lkrehi 4765 32 RR rr NN cord-335975-m6lkrehi 4765 33 = = SYM cord-335975-m6lkrehi 4765 34 1 1 CD cord-335975-m6lkrehi 4765 35 , , , cord-335975-m6lkrehi 4765 36 CI CI NNP cord-335975-m6lkrehi 4765 37 95 95 CD cord-335975-m6lkrehi 4765 38 % % NN cord-335975-m6lkrehi 4765 39 0.66 0.66 CD cord-335975-m6lkrehi 4765 40 - - HYPH cord-335975-m6lkrehi 4765 41 1.51 1.51 CD cord-335975-m6lkrehi 4765 42 ) ) -RRB- cord-335975-m6lkrehi 4765 43 or or CC cord-335975-m6lkrehi 4765 44 the the DT cord-335975-m6lkrehi 4765 45 mortality mortality NN cord-335975-m6lkrehi 4765 46 rates rate NNS cord-335975-m6lkrehi 4765 47 ( ( -LRB- cord-335975-m6lkrehi 4765 48 RR rr NN cord-335975-m6lkrehi 4765 49 = = SYM cord-335975-m6lkrehi 4765 50 1.04 1.04 CD cord-335975-m6lkrehi 4765 51 , , , cord-335975-m6lkrehi 4765 52 CI CI NNP cord-335975-m6lkrehi 4765 53 95 95 CD cord-335975-m6lkrehi 4765 54 % % NN cord-335975-m6lkrehi 4765 55 0.81 0.81 CD cord-335975-m6lkrehi 4765 56 - - SYM cord-335975-m6lkrehi 4765 57 1.33 1.33 CD cord-335975-m6lkrehi 4765 58 ) ) -RRB- cord-335975-m6lkrehi 4765 59 . . . cord-335975-m6lkrehi 4766 1 Conclusion conclusion NN cord-335975-m6lkrehi 4766 2 : : : cord-335975-m6lkrehi 4767 1 Colonization colonization NN cord-335975-m6lkrehi 4767 2 and and CC cord-335975-m6lkrehi 4767 3 infection infection NN cord-335975-m6lkrehi 4767 4 with with IN cord-335975-m6lkrehi 4767 5 PA PA NNP cord-335975-m6lkrehi 4767 6 are be VBP cord-335975-m6lkrehi 4767 7 risk risk NN cord-335975-m6lkrehi 4767 8 factors factor NNS cord-335975-m6lkrehi 4767 9 of of IN cord-335975-m6lkrehi 4767 10 increased increase VBN cord-335975-m6lkrehi 4767 11 mortality mortality NN cord-335975-m6lkrehi 4767 12 rates rate NNS cord-335975-m6lkrehi 4767 13 and and CC cord-335975-m6lkrehi 4767 14 ALOS ALOS NNP cord-335975-m6lkrehi 4767 15 in in IN cord-335975-m6lkrehi 4767 16 ICU ICU NNP cord-335975-m6lkrehi 4767 17 . . . cord-335975-m6lkrehi 4768 1 An an DT cord-335975-m6lkrehi 4768 2 antibiotic antibiotic JJ cord-335975-m6lkrehi 4768 3 stewardship stewardship NN cord-335975-m6lkrehi 4768 4 program program NN cord-335975-m6lkrehi 4768 5 allows allow VBZ cord-335975-m6lkrehi 4768 6 to to TO cord-335975-m6lkrehi 4768 7 reduce reduce VB cord-335975-m6lkrehi 4768 8 the the DT cord-335975-m6lkrehi 4768 9 incidence incidence NN cord-335975-m6lkrehi 4768 10 of of IN cord-335975-m6lkrehi 4768 11 patients patient NNS cord-335975-m6lkrehi 4768 12 having have VBG cord-335975-m6lkrehi 4768 13 a a DT cord-335975-m6lkrehi 4768 14 positive positive JJ cord-335975-m6lkrehi 4768 15 sample sample NN cord-335975-m6lkrehi 4768 16 with with IN cord-335975-m6lkrehi 4768 17 PA PA NNP cord-335975-m6lkrehi 4768 18 , , , cord-335975-m6lkrehi 4768 19 and and CC cord-335975-m6lkrehi 4768 20 the the DT cord-335975-m6lkrehi 4768 21 antibiotic antibiotic JJ cord-335975-m6lkrehi 4768 22 resistance resistance NN cord-335975-m6lkrehi 4768 23 of of IN cord-335975-m6lkrehi 4768 24 PA PA NNP cord-335975-m6lkrehi 4768 25 strains strain NNS cord-335975-m6lkrehi 4768 26 , , , cord-335975-m6lkrehi 4768 27 without without IN cord-335975-m6lkrehi 4768 28 reducing reduce VBG cord-335975-m6lkrehi 4768 29 the the DT cord-335975-m6lkrehi 4768 30 infection infection NN cord-335975-m6lkrehi 4768 31 rate rate NN cord-335975-m6lkrehi 4768 32 of of IN cord-335975-m6lkrehi 4768 33 these these DT cord-335975-m6lkrehi 4768 34 patients patient NNS cord-335975-m6lkrehi 4768 35 . . . cord-335975-m6lkrehi 4769 1 Impact impact NN cord-335975-m6lkrehi 4769 2 of of IN cord-335975-m6lkrehi 4769 3 a a DT cord-335975-m6lkrehi 4769 4 local local JJ cord-335975-m6lkrehi 4769 5 care care NN cord-335975-m6lkrehi 4769 6 protocol protocol NN cord-335975-m6lkrehi 4769 7 on on IN cord-335975-m6lkrehi 4769 8 the the DT cord-335975-m6lkrehi 4769 9 duration duration NN cord-335975-m6lkrehi 4769 10 of of IN cord-335975-m6lkrehi 4769 11 antibiotic antibiotic JJ cord-335975-m6lkrehi 4769 12 therapy therapy NN cord-335975-m6lkrehi 4769 13 in in IN cord-335975-m6lkrehi 4769 14 community community NN cord-335975-m6lkrehi 4769 15 - - HYPH cord-335975-m6lkrehi 4769 16 acquired acquire VBN cord-335975-m6lkrehi 4769 17 peritonitis peritonitis NN cord-335975-m6lkrehi 4769 18 : : : cord-335975-m6lkrehi 4769 19 10 10 CD cord-335975-m6lkrehi 4769 20 years year NNS cord-335975-m6lkrehi 4769 21 of of IN cord-335975-m6lkrehi 4769 22 experience experience NN cord-335975-m6lkrehi 4769 23 Introduction introduction NN cord-335975-m6lkrehi 4769 24 : : : cord-335975-m6lkrehi 4770 1 The the DT cord-335975-m6lkrehi 4770 2 use use NN cord-335975-m6lkrehi 4770 3 of of IN cord-335975-m6lkrehi 4770 4 antibiotics antibiotic NNS cord-335975-m6lkrehi 4770 5 is be VBZ cord-335975-m6lkrehi 4770 6 a a DT cord-335975-m6lkrehi 4770 7 major major JJ cord-335975-m6lkrehi 4770 8 public public JJ cord-335975-m6lkrehi 4770 9 health health NN cord-335975-m6lkrehi 4770 10 , , , cord-335975-m6lkrehi 4770 11 economic economic JJ cord-335975-m6lkrehi 4770 12 and and CC cord-335975-m6lkrehi 4770 13 ecological ecological JJ cord-335975-m6lkrehi 4770 14 challenge challenge NN cord-335975-m6lkrehi 4770 15 . . . cord-335975-m6lkrehi 4771 1 In in IN cord-335975-m6lkrehi 4771 2 2011 2011 CD cord-335975-m6lkrehi 4771 3 , , , cord-335975-m6lkrehi 4771 4 a a DT cord-335975-m6lkrehi 4771 5 French french JJ cord-335975-m6lkrehi 4771 6 national national JJ cord-335975-m6lkrehi 4771 7 warning warning NN cord-335975-m6lkrehi 4771 8 plan plan NN cord-335975-m6lkrehi 4771 9 was be VBD cord-335975-m6lkrehi 4771 10 created create VBN cord-335975-m6lkrehi 4771 11 to to TO cord-335975-m6lkrehi 4771 12 manage manage VB cord-335975-m6lkrehi 4771 13 the the DT cord-335975-m6lkrehi 4771 14 use use NN cord-335975-m6lkrehi 4771 15 of of IN cord-335975-m6lkrehi 4771 16 antibiotics antibiotic NNS cord-335975-m6lkrehi 4771 17 . . . cord-335975-m6lkrehi 4772 1 It -PRON- PRP cord-335975-m6lkrehi 4772 2 advocates advocate VBZ cord-335975-m6lkrehi 4772 3 monitoring monitoring NN cord-335975-m6lkrehi 4772 4 of of IN cord-335975-m6lkrehi 4772 5 the the DT cord-335975-m6lkrehi 4772 6 prescription prescription NN cord-335975-m6lkrehi 4772 7 of of IN cord-335975-m6lkrehi 4772 8 antibiotics antibiotic NNS cord-335975-m6lkrehi 4772 9 and and CC cord-335975-m6lkrehi 4772 10 the the DT cord-335975-m6lkrehi 4772 11 implementation implementation NN cord-335975-m6lkrehi 4772 12 of of IN cord-335975-m6lkrehi 4772 13 measures measure NNS cord-335975-m6lkrehi 4772 14 to to TO cord-335975-m6lkrehi 4772 15 assess assess VB cord-335975-m6lkrehi 4772 16 professional professional JJ cord-335975-m6lkrehi 4772 17 practices practice NNS cord-335975-m6lkrehi 4772 18 . . . cord-335975-m6lkrehi 4773 1 The the DT cord-335975-m6lkrehi 4773 2 great great JJ cord-335975-m6lkrehi 4773 3 majority majority NN cord-335975-m6lkrehi 4773 4 of of IN cord-335975-m6lkrehi 4773 5 guidelines guideline NNS cord-335975-m6lkrehi 4773 6 concerning concern VBG cord-335975-m6lkrehi 4773 7 the the DT cord-335975-m6lkrehi 4773 8 duration duration NN cord-335975-m6lkrehi 4773 9 of of IN cord-335975-m6lkrehi 4773 10 antibiotic antibiotic JJ cord-335975-m6lkrehi 4773 11 therapy therapy NN cord-335975-m6lkrehi 4773 12 in in IN cord-335975-m6lkrehi 4773 13 community community NN cord-335975-m6lkrehi 4773 14 - - HYPH cord-335975-m6lkrehi 4773 15 acquired acquire VBN cord-335975-m6lkrehi 4773 16 peritonitis peritonitis NN cord-335975-m6lkrehi 4773 17 are be VBP cord-335975-m6lkrehi 4773 18 based base VBN cord-335975-m6lkrehi 4773 19 on on IN cord-335975-m6lkrehi 4773 20 studies study NNS cord-335975-m6lkrehi 4773 21 with with IN cord-335975-m6lkrehi 4773 22 low low JJ cord-335975-m6lkrehi 4773 23 level level NN cord-335975-m6lkrehi 4773 24 of of IN cord-335975-m6lkrehi 4773 25 evidence evidence NN cord-335975-m6lkrehi 4773 26 . . . cord-335975-m6lkrehi 4774 1 The the DT cord-335975-m6lkrehi 4774 2 objective objective NN cord-335975-m6lkrehi 4774 3 of of IN cord-335975-m6lkrehi 4774 4 this this DT cord-335975-m6lkrehi 4774 5 study study NN cord-335975-m6lkrehi 4774 6 is be VBZ cord-335975-m6lkrehi 4774 7 to to TO cord-335975-m6lkrehi 4774 8 evaluate evaluate VB cord-335975-m6lkrehi 4774 9 the the DT cord-335975-m6lkrehi 4774 10 implementation implementation NN cord-335975-m6lkrehi 4774 11 of of IN cord-335975-m6lkrehi 4774 12 a a DT cord-335975-m6lkrehi 4774 13 Standardized Standardized NNP cord-335975-m6lkrehi 4774 14 Operational Operational NNP cord-335975-m6lkrehi 4774 15 Report Report NNP cord-335975-m6lkrehi 4774 16 ( ( -LRB- cord-335975-m6lkrehi 4774 17 SOR SOR NNP cord-335975-m6lkrehi 4774 18 ) ) -RRB- cord-335975-m6lkrehi 4774 19 with with IN cord-335975-m6lkrehi 4774 20 a a DT cord-335975-m6lkrehi 4774 21 local local JJ cord-335975-m6lkrehi 4774 22 antibiotic antibiotic JJ cord-335975-m6lkrehi 4774 23 protocol protocol NN cord-335975-m6lkrehi 4774 24 in in IN cord-335975-m6lkrehi 4774 25 the the DT cord-335975-m6lkrehi 4774 26 management management NN cord-335975-m6lkrehi 4774 27 of of IN cord-335975-m6lkrehi 4774 28 community community NN cord-335975-m6lkrehi 4774 29 - - HYPH cord-335975-m6lkrehi 4774 30 acquired acquire VBN cord-335975-m6lkrehi 4774 31 peritonitis peritonitis NN cord-335975-m6lkrehi 4774 32 at at IN cord-335975-m6lkrehi 4774 33 our -PRON- PRP$ cord-335975-m6lkrehi 4774 34 institution institution NN cord-335975-m6lkrehi 4774 35 . . . cord-335975-m6lkrehi 4775 1 Patients patient NNS cord-335975-m6lkrehi 4775 2 and and CC cord-335975-m6lkrehi 4775 3 methods method NNS cord-335975-m6lkrehi 4776 1 : : : cord-335975-m6lkrehi 4776 2 This this DT cord-335975-m6lkrehi 4776 3 is be VBZ cord-335975-m6lkrehi 4776 4 a a DT cord-335975-m6lkrehi 4776 5 monocentric monocentric JJ cord-335975-m6lkrehi 4776 6 , , , cord-335975-m6lkrehi 4776 7 prospective prospective JJ cord-335975-m6lkrehi 4776 8 cohort cohort NN cord-335975-m6lkrehi 4776 9 study study NN cord-335975-m6lkrehi 4776 10 - - : cord-335975-m6lkrehi 4776 11 before before IN cord-335975-m6lkrehi 4776 12 and and CC cord-335975-m6lkrehi 4776 13 after after IN cord-335975-m6lkrehi 4776 14 the the DT cord-335975-m6lkrehi 4776 15 establishment establishment NN cord-335975-m6lkrehi 4776 16 of of IN cord-335975-m6lkrehi 4776 17 the the DT cord-335975-m6lkrehi 4776 18 SOR SOR NNP cord-335975-m6lkrehi 4776 19 . . . cord-335975-m6lkrehi 4777 1 The the DT cord-335975-m6lkrehi 4777 2 primary primary JJ cord-335975-m6lkrehi 4777 3 endpoint endpoint NN cord-335975-m6lkrehi 4777 4 is be VBZ cord-335975-m6lkrehi 4777 5 duration duration NN cord-335975-m6lkrehi 4777 6 of of IN cord-335975-m6lkrehi 4777 7 antibiotic antibiotic JJ cord-335975-m6lkrehi 4777 8 therapy therapy NN cord-335975-m6lkrehi 4777 9 . . . cord-335975-m6lkrehi 4778 1 Secondary secondary JJ cord-335975-m6lkrehi 4778 2 endpoints endpoint NNS cord-335975-m6lkrehi 4778 3 are be VBP cord-335975-m6lkrehi 4778 4 length length NN cord-335975-m6lkrehi 4778 5 of of IN cord-335975-m6lkrehi 4778 6 hospitalization hospitalization NN cord-335975-m6lkrehi 4778 7 , , , cord-335975-m6lkrehi 4778 8 infectious infectious JJ cord-335975-m6lkrehi 4778 9 complications complication NNS cord-335975-m6lkrehi 4778 10 , , , cord-335975-m6lkrehi 4778 11 mortality mortality NN cord-335975-m6lkrehi 4778 12 , , , cord-335975-m6lkrehi 4778 13 and and CC cord-335975-m6lkrehi 4778 14 changes change NNS cord-335975-m6lkrehi 4778 15 in in IN cord-335975-m6lkrehi 4778 16 local local JJ cord-335975-m6lkrehi 4778 17 bacterial bacterial JJ cord-335975-m6lkrehi 4778 18 ecology ecology NN cord-335975-m6lkrehi 4778 19 . . . cord-335975-m6lkrehi 4779 1 We -PRON- PRP cord-335975-m6lkrehi 4779 2 have have VBP cord-335975-m6lkrehi 4779 3 also also RB cord-335975-m6lkrehi 4779 4 evaluated evaluate VBN cord-335975-m6lkrehi 4779 5 retrospectively retrospectively RB cord-335975-m6lkrehi 4779 6 these these DT cord-335975-m6lkrehi 4779 7 different different JJ cord-335975-m6lkrehi 4779 8 criteria criterion NNS cord-335975-m6lkrehi 4779 9 on on IN cord-335975-m6lkrehi 4779 10 cohort cohort NN cord-335975-m6lkrehi 4779 11 was be VBD cord-335975-m6lkrehi 4779 12 constituted constitute VBN cord-335975-m6lkrehi 4779 13 since since IN cord-335975-m6lkrehi 4779 14 2005 2005 CD cord-335975-m6lkrehi 4779 15 . . . cord-335975-m6lkrehi 4780 1 Results result NNS cord-335975-m6lkrehi 4780 2 : : : cord-335975-m6lkrehi 4781 1 A a DT cord-335975-m6lkrehi 4781 2 total total NN cord-335975-m6lkrehi 4781 3 of of IN cord-335975-m6lkrehi 4781 4 205 205 CD cord-335975-m6lkrehi 4781 5 patients patient NNS cord-335975-m6lkrehi 4781 6 were be VBD cord-335975-m6lkrehi 4781 7 enrolled enrol VBN cord-335975-m6lkrehi 4781 8 from from IN cord-335975-m6lkrehi 4781 9 January January NNP cord-335975-m6lkrehi 4781 10 2011 2011 CD cord-335975-m6lkrehi 4781 11 to to IN cord-335975-m6lkrehi 4781 12 June June NNP cord-335975-m6lkrehi 4781 13 2013 2013 CD cord-335975-m6lkrehi 4781 14 and and CC cord-335975-m6lkrehi 4781 15 231 231 CD cord-335975-m6lkrehi 4781 16 patients patient NNS cord-335975-m6lkrehi 4781 17 from from IN cord-335975-m6lkrehi 4781 18 May May NNP cord-335975-m6lkrehi 4781 19 2014 2014 CD cord-335975-m6lkrehi 4781 20 to to IN cord-335975-m6lkrehi 4781 21 May May NNP cord-335975-m6lkrehi 4781 22 2016 2016 CD cord-335975-m6lkrehi 4781 23 . . . cord-335975-m6lkrehi 4782 1 The the DT cord-335975-m6lkrehi 4782 2 duration duration NN cord-335975-m6lkrehi 4782 3 of of IN cord-335975-m6lkrehi 4782 4 antibiotic antibiotic JJ cord-335975-m6lkrehi 4782 5 therapy therapy NN cord-335975-m6lkrehi 4782 6 was be VBD cord-335975-m6lkrehi 4782 7 decreased decrease VBN cord-335975-m6lkrehi 4782 8 by by IN cord-335975-m6lkrehi 4782 9 7 7 CD cord-335975-m6lkrehi 4782 10 to to TO cord-335975-m6lkrehi 4782 11 3 3 CD cord-335975-m6lkrehi 4782 12 days day NNS cord-335975-m6lkrehi 4782 13 in in IN cord-335975-m6lkrehi 4782 14 localized localized JJ cord-335975-m6lkrehi 4782 15 peritonitis peritonitis NN cord-335975-m6lkrehi 4782 16 ( ( -LRB- cord-335975-m6lkrehi 4782 17 p p NN cord-335975-m6lkrehi 4782 18 < < XX cord-335975-m6lkrehi 4782 19 0.0001 0.0001 CD cord-335975-m6lkrehi 4782 20 ) ) -RRB- cord-335975-m6lkrehi 4782 21 and and CC cord-335975-m6lkrehi 4782 22 9 9 CD cord-335975-m6lkrehi 4782 23 to to TO cord-335975-m6lkrehi 4782 24 7 7 CD cord-335975-m6lkrehi 4782 25 days day NNS cord-335975-m6lkrehi 4782 26 in in IN cord-335975-m6lkrehi 4782 27 generalized generalized JJ cord-335975-m6lkrehi 4782 28 peritonitis peritonitis NN cord-335975-m6lkrehi 4782 29 ( ( -LRB- cord-335975-m6lkrehi 4782 30 p p NN cord-335975-m6lkrehi 4782 31 < < XX cord-335975-m6lkrehi 4782 32 0.0001 0.0001 CD cord-335975-m6lkrehi 4782 33 ) ) -RRB- cord-335975-m6lkrehi 4783 1 ( ( -LRB- cord-335975-m6lkrehi 4783 2 Figure figure NN cord-335975-m6lkrehi 4783 3 ) ) -RRB- cord-335975-m6lkrehi 4783 4 . . . cord-335975-m6lkrehi 4784 1 However however RB cord-335975-m6lkrehi 4784 2 , , , cord-335975-m6lkrehi 4784 3 the the DT cord-335975-m6lkrehi 4784 4 compliance compliance NN cord-335975-m6lkrehi 4784 5 to to IN cord-335975-m6lkrehi 4784 6 the the DT cord-335975-m6lkrehi 4784 7 protocol protocol NN cord-335975-m6lkrehi 4784 8 was be VBD cord-335975-m6lkrehi 4784 9 only only RB cord-335975-m6lkrehi 4784 10 66 66 CD cord-335975-m6lkrehi 4784 11 % % NN cord-335975-m6lkrehi 4784 12 , , , cord-335975-m6lkrehi 4784 13 which which WDT cord-335975-m6lkrehi 4784 14 leads lead VBZ cord-335975-m6lkrehi 4784 15 to to IN cord-335975-m6lkrehi 4784 16 an an DT cord-335975-m6lkrehi 4784 17 increase increase NN cord-335975-m6lkrehi 4784 18 in in IN cord-335975-m6lkrehi 4784 19 the the DT cord-335975-m6lkrehi 4784 20 duration duration NN cord-335975-m6lkrehi 4784 21 of of IN cord-335975-m6lkrehi 4784 22 antibiotic antibiotic JJ cord-335975-m6lkrehi 4784 23 therapy therapy NN cord-335975-m6lkrehi 4784 24 and and CC cord-335975-m6lkrehi 4784 25 hospital hospital NN cord-335975-m6lkrehi 4784 26 stay stay NN cord-335975-m6lkrehi 4784 27 when when WRB cord-335975-m6lkrehi 4784 28 not not RB cord-335975-m6lkrehi 4784 29 used use VBN cord-335975-m6lkrehi 4785 1 ( ( -LRB- cord-335975-m6lkrehi 4785 2 p p NN cord-335975-m6lkrehi 4785 3 < < XX cord-335975-m6lkrehi 4785 4 0.0001 0.0001 CD cord-335975-m6lkrehi 4785 5 ) ) -RRB- cord-335975-m6lkrehi 4785 6 . . . cord-335975-m6lkrehi 4786 1 The the DT cord-335975-m6lkrehi 4786 2 hospital hospital NN cord-335975-m6lkrehi 4786 3 stay stay NN cord-335975-m6lkrehi 4786 4 decreased decrease VBD cord-335975-m6lkrehi 4786 5 from from IN cord-335975-m6lkrehi 4786 6 7 7 CD cord-335975-m6lkrehi 4786 7 to to TO cord-335975-m6lkrehi 4786 8 4 4 CD cord-335975-m6lkrehi 4786 9 days day NNS cord-335975-m6lkrehi 4786 10 in in IN cord-335975-m6lkrehi 4786 11 the the DT cord-335975-m6lkrehi 4786 12 localized localized JJ cord-335975-m6lkrehi 4786 13 peritonitis peritonitis NN cord-335975-m6lkrehi 4786 14 ( ( -LRB- cord-335975-m6lkrehi 4786 15 p p NN cord-335975-m6lkrehi 4786 16 < < XX cord-335975-m6lkrehi 4786 17 0.0001 0.0001 CD cord-335975-m6lkrehi 4786 18 ) ) -RRB- cord-335975-m6lkrehi 4786 19 . . . cord-335975-m6lkrehi 4787 1 Amoxicillin Amoxicillin NNP cord-335975-m6lkrehi 4787 2 clavulanic clavulanic NNP cord-335975-m6lkrehi 4787 3 acid acid NN cord-335975-m6lkrehi 4787 4 ( ( -LRB- cord-335975-m6lkrehi 4787 5 AMC AMC NNP cord-335975-m6lkrehi 4787 6 ) ) -RRB- cord-335975-m6lkrehi 4787 7 is be VBZ cord-335975-m6lkrehi 4787 8 the the DT cord-335975-m6lkrehi 4787 9 most most RBS cord-335975-m6lkrehi 4787 10 used use VBN cord-335975-m6lkrehi 4787 11 antibiotic antibiotic NN cord-335975-m6lkrehi 4787 12 with with IN cord-335975-m6lkrehi 4787 13 an an DT cord-335975-m6lkrehi 4787 14 efficiency efficiency NN cord-335975-m6lkrehi 4787 15 of of IN cord-335975-m6lkrehi 4787 16 77 77 CD cord-335975-m6lkrehi 4787 17 % % NN cord-335975-m6lkrehi 4787 18 . . . cord-335975-m6lkrehi 4788 1 There there EX cord-335975-m6lkrehi 4788 2 was be VBD cord-335975-m6lkrehi 4788 3 no no DT cord-335975-m6lkrehi 4788 4 impact impact NN cord-335975-m6lkrehi 4788 5 on on IN cord-335975-m6lkrehi 4788 6 morbidity morbidity NN cord-335975-m6lkrehi 4788 7 and and CC cord-335975-m6lkrehi 4788 8 mortality mortality NN cord-335975-m6lkrehi 4788 9 when when WRB cord-335975-m6lkrehi 4788 10 AMC AMC NNP cord-335975-m6lkrehi 4788 11 was be VBD cord-335975-m6lkrehi 4788 12 inadequate inadequate JJ cord-335975-m6lkrehi 4788 13 . . . cord-335975-m6lkrehi 4789 1 The the DT cord-335975-m6lkrehi 4789 2 bacterial bacterial JJ cord-335975-m6lkrehi 4789 3 ecology ecology NN cord-335975-m6lkrehi 4789 4 was be VBD cord-335975-m6lkrehi 4789 5 not not RB cord-335975-m6lkrehi 4789 6 modified modify VBN cord-335975-m6lkrehi 4789 7 , , , cord-335975-m6lkrehi 4789 8 the the DT cord-335975-m6lkrehi 4789 9 rate rate NN cord-335975-m6lkrehi 4789 10 of of IN cord-335975-m6lkrehi 4789 11 extended extend VBN cord-335975-m6lkrehi 4789 12 - - HYPH cord-335975-m6lkrehi 4789 13 spectrum spectrum NN cord-335975-m6lkrehi 4789 14 beta beta NN cord-335975-m6lkrehi 4789 15 - - HYPH cord-335975-m6lkrehi 4789 16 lactamase lactamase NN cord-335975-m6lkrehi 4789 17 ( ( -LRB- cord-335975-m6lkrehi 4789 18 ESBL ESBL NNP cord-335975-m6lkrehi 4789 19 ) ) -RRB- cord-335975-m6lkrehi 4789 20 producing produce VBG cord-335975-m6lkrehi 4789 21 enterobacteria enterobacteria NNP cord-335975-m6lkrehi 4789 22 ( ( -LRB- cord-335975-m6lkrehi 4789 23 ESBLE ESBLE NNP cord-335975-m6lkrehi 4789 24 ) ) -RRB- cord-335975-m6lkrehi 4789 25 was be VBD cord-335975-m6lkrehi 4789 26 3 3 CD cord-335975-m6lkrehi 4789 27 % % NN cord-335975-m6lkrehi 4789 28 . . . cord-335975-m6lkrehi 4790 1 The the DT cord-335975-m6lkrehi 4790 2 use use NN cord-335975-m6lkrehi 4790 3 of of IN cord-335975-m6lkrehi 4790 4 a a DT cord-335975-m6lkrehi 4790 5 standardized standardized JJ cord-335975-m6lkrehi 4790 6 antibiotic antibiotic JJ cord-335975-m6lkrehi 4790 7 protocol protocol NN cord-335975-m6lkrehi 4790 8 reduced reduce VBD cord-335975-m6lkrehi 4790 9 antibiotic antibiotic JJ cord-335975-m6lkrehi 4790 10 therapy therapy NN cord-335975-m6lkrehi 4790 11 duration duration NN cord-335975-m6lkrehi 4790 12 and and CC cord-335975-m6lkrehi 4790 13 hospital hospital NN cord-335975-m6lkrehi 4790 14 stay stay NN cord-335975-m6lkrehi 4790 15 , , , cord-335975-m6lkrehi 4790 16 particularly particularly RB cord-335975-m6lkrehi 4790 17 in in IN cord-335975-m6lkrehi 4790 18 localized localized JJ cord-335975-m6lkrehi 4790 19 peritonitis peritonitis NN cord-335975-m6lkrehi 4790 20 despite despite IN cord-335975-m6lkrehi 4790 21 incomplete incomplete JJ cord-335975-m6lkrehi 4790 22 compliance compliance NN cord-335975-m6lkrehi 4790 23 to to IN cord-335975-m6lkrehi 4790 24 the the DT cord-335975-m6lkrehi 4790 25 protocol protocol NN cord-335975-m6lkrehi 4790 26 . . . cord-335975-m6lkrehi 4791 1 To to TO cord-335975-m6lkrehi 4791 2 achieve achieve VB cord-335975-m6lkrehi 4791 3 full full JJ cord-335975-m6lkrehi 4791 4 compliance compliance NN cord-335975-m6lkrehi 4791 5 , , , cord-335975-m6lkrehi 4791 6 we -PRON- PRP cord-335975-m6lkrehi 4791 7 need need VBP cord-335975-m6lkrehi 4791 8 to to TO cord-335975-m6lkrehi 4791 9 continue continue VB cord-335975-m6lkrehi 4791 10 the the DT cord-335975-m6lkrehi 4791 11 training training NN cord-335975-m6lkrehi 4791 12 of of IN cord-335975-m6lkrehi 4791 13 different different JJ cord-335975-m6lkrehi 4791 14 physicians physician NNS cord-335975-m6lkrehi 4791 15 and and CC cord-335975-m6lkrehi 4791 16 continue continue VBP cord-335975-m6lkrehi 4791 17 the the DT cord-335975-m6lkrehi 4791 18 spread spread NN cord-335975-m6lkrehi 4791 19 of of IN cord-335975-m6lkrehi 4791 20 the the DT cord-335975-m6lkrehi 4791 21 protocol protocol NN cord-335975-m6lkrehi 4791 22 . . . cord-335975-m6lkrehi 4792 1 Introduction introduction NN cord-335975-m6lkrehi 4792 2 : : : cord-335975-m6lkrehi 4793 1 Bacterial bacterial JJ cord-335975-m6lkrehi 4793 2 meningitis meningitis NN cord-335975-m6lkrehi 4793 3 is be VBZ cord-335975-m6lkrehi 4793 4 an an DT cord-335975-m6lkrehi 4793 5 important important JJ cord-335975-m6lkrehi 4793 6 public public JJ cord-335975-m6lkrehi 4793 7 health health NN cord-335975-m6lkrehi 4793 8 problem problem NN cord-335975-m6lkrehi 4793 9 because because IN cord-335975-m6lkrehi 4793 10 of of IN cord-335975-m6lkrehi 4793 11 its -PRON- PRP$ cord-335975-m6lkrehi 4793 12 frequency frequency NN cord-335975-m6lkrehi 4793 13 and and CC cord-335975-m6lkrehi 4793 14 severity severity NN cord-335975-m6lkrehi 4793 15 . . . cord-335975-m6lkrehi 4794 1 They -PRON- PRP cord-335975-m6lkrehi 4794 2 remain remain VBP cord-335975-m6lkrehi 4794 3 a a DT cord-335975-m6lkrehi 4794 4 major major JJ cord-335975-m6lkrehi 4794 5 cause cause NN cord-335975-m6lkrehi 4794 6 of of IN cord-335975-m6lkrehi 4794 7 mortality mortality NN cord-335975-m6lkrehi 4794 8 and and CC cord-335975-m6lkrehi 4794 9 morbidity morbidity NN cord-335975-m6lkrehi 4794 10 in in IN cord-335975-m6lkrehi 4794 11 developing develop VBG cord-335975-m6lkrehi 4794 12 countries country NNS cord-335975-m6lkrehi 4794 13 . . . cord-335975-m6lkrehi 4795 1 The the DT cord-335975-m6lkrehi 4795 2 aim aim NN cord-335975-m6lkrehi 4795 3 of of IN cord-335975-m6lkrehi 4795 4 our -PRON- PRP$ cord-335975-m6lkrehi 4795 5 work work NN cord-335975-m6lkrehi 4795 6 is be VBZ cord-335975-m6lkrehi 4795 7 to to TO cord-335975-m6lkrehi 4795 8 establish establish VB cord-335975-m6lkrehi 4795 9 the the DT cord-335975-m6lkrehi 4795 10 epidemiological epidemiological JJ cord-335975-m6lkrehi 4795 11 characteristics characteristic NNS cord-335975-m6lkrehi 4795 12 and and CC cord-335975-m6lkrehi 4795 13 the the DT cord-335975-m6lkrehi 4795 14 prognostic prognostic JJ cord-335975-m6lkrehi 4795 15 factors factor NNS cord-335975-m6lkrehi 4795 16 . . . cord-335975-m6lkrehi 4796 1 Patients patient NNS cord-335975-m6lkrehi 4796 2 and and CC cord-335975-m6lkrehi 4796 3 methods method NNS cord-335975-m6lkrehi 4796 4 : : : cord-335975-m6lkrehi 4796 5 we -PRON- PRP cord-335975-m6lkrehi 4796 6 did do VBD cord-335975-m6lkrehi 4796 7 a a DT cord-335975-m6lkrehi 4796 8 retrospective retrospective JJ cord-335975-m6lkrehi 4796 9 descriptive descriptive JJ cord-335975-m6lkrehi 4796 10 and and CC cord-335975-m6lkrehi 4796 11 analytical analytical JJ cord-335975-m6lkrehi 4796 12 study study NN cord-335975-m6lkrehi 4797 1 and and CC cord-335975-m6lkrehi 4797 2 we -PRON- PRP cord-335975-m6lkrehi 4797 3 included include VBD cord-335975-m6lkrehi 4797 4 all all PDT cord-335975-m6lkrehi 4797 5 the the DT cord-335975-m6lkrehi 4797 6 patients patient NNS cord-335975-m6lkrehi 4797 7 admitted admit VBN cord-335975-m6lkrehi 4797 8 for for IN cord-335975-m6lkrehi 4797 9 severe severe JJ cord-335975-m6lkrehi 4797 10 meningitis meningitis NN cord-335975-m6lkrehi 4797 11 for for IN cord-335975-m6lkrehi 4797 12 1 1 CD cord-335975-m6lkrehi 4797 13 year year NN cord-335975-m6lkrehi 4797 14 in in IN cord-335975-m6lkrehi 4797 15 the the DT cord-335975-m6lkrehi 4797 16 medical medical JJ cord-335975-m6lkrehi 4797 17 intensive intensive JJ cord-335975-m6lkrehi 4797 18 care care NN cord-335975-m6lkrehi 4797 19 unit unit NN cord-335975-m6lkrehi 4797 20 of of IN cord-335975-m6lkrehi 4797 21 the the DT cord-335975-m6lkrehi 4797 22 university university NN cord-335975-m6lkrehi 4797 23 teaching teaching NN cord-335975-m6lkrehi 4797 24 hospital hospital NN cord-335975-m6lkrehi 4797 25 Ibn Ibn NNP cord-335975-m6lkrehi 4797 26 Rushd Rushd NNP cord-335975-m6lkrehi 4797 27 at at IN cord-335975-m6lkrehi 4797 28 Casablanca Casablanca NNP cord-335975-m6lkrehi 4797 29 - - HYPH cord-335975-m6lkrehi 4797 30 Morocco Morocco NNP cord-335975-m6lkrehi 4797 31 . . . cord-335975-m6lkrehi 4798 1 Results result NNS cord-335975-m6lkrehi 4798 2 : : : cord-335975-m6lkrehi 4798 3 70 70 CD cord-335975-m6lkrehi 4798 4 patients patient NNS cord-335975-m6lkrehi 4798 5 were be VBD cord-335975-m6lkrehi 4798 6 included include VBN cord-335975-m6lkrehi 4798 7 . . . cord-335975-m6lkrehi 4799 1 The the DT cord-335975-m6lkrehi 4799 2 incidence incidence NN cord-335975-m6lkrehi 4799 3 of of IN cord-335975-m6lkrehi 4799 4 severe severe JJ cord-335975-m6lkrehi 4799 5 meningtis meningtis NN cord-335975-m6lkrehi 4799 6 was be VBD cord-335975-m6lkrehi 4799 7 12.61 12.61 CD cord-335975-m6lkrehi 4799 8 % % NN cord-335975-m6lkrehi 4799 9 , , , cord-335975-m6lkrehi 4799 10 the the DT cord-335975-m6lkrehi 4799 11 mean mean JJ cord-335975-m6lkrehi 4799 12 age age NN cord-335975-m6lkrehi 4799 13 was be VBD cord-335975-m6lkrehi 4799 14 44 44 CD cord-335975-m6lkrehi 4799 15 years year NNS cord-335975-m6lkrehi 4799 16 old old JJ cord-335975-m6lkrehi 4799 17 and and CC cord-335975-m6lkrehi 4799 18 the the DT cord-335975-m6lkrehi 4799 19 sex sex NN cord-335975-m6lkrehi 4799 20 ratio ratio NN cord-335975-m6lkrehi 4800 1 H H NNP cord-335975-m6lkrehi 4800 2 F F NNP cord-335975-m6lkrehi 4800 3 was be VBD cord-335975-m6lkrehi 4800 4 1,06.24,3 1,06.24,3 CD cord-335975-m6lkrehi 4800 5 % % NN cord-335975-m6lkrehi 4800 6 were be VBD cord-335975-m6lkrehi 4800 7 pneumococcal pneumococcal JJ cord-335975-m6lkrehi 4800 8 meningitis meningitis NN cord-335975-m6lkrehi 4800 9 and and CC cord-335975-m6lkrehi 4800 10 20 20 CD cord-335975-m6lkrehi 4800 11 % % NN cord-335975-m6lkrehi 4800 12 were be VBD cord-335975-m6lkrehi 4800 13 tuberculosis tuberculosis NN cord-335975-m6lkrehi 4801 1 In in IN cord-335975-m6lkrehi 4801 2 univariate univariate JJ cord-335975-m6lkrehi 4801 3 analysis analysis NN cord-335975-m6lkrehi 4801 4 , , , cord-335975-m6lkrehi 4801 5 factors factor NNS cord-335975-m6lkrehi 4801 6 influencing influence VBG cord-335975-m6lkrehi 4801 7 mortality mortality NN cord-335975-m6lkrehi 4801 8 significantly significantly RB cord-335975-m6lkrehi 4801 9 - - : cord-335975-m6lkrehi 4801 10 The the DT cord-335975-m6lkrehi 4801 11 male male JJ cord-335975-m6lkrehi 4801 12 sex sex NN cord-335975-m6lkrehi 4801 13 Patients patient NNS cord-335975-m6lkrehi 4801 14 with with IN cord-335975-m6lkrehi 4801 15 pulmonary pulmonary JJ cord-335975-m6lkrehi 4801 16 tuberculosis tuberculosis NN cord-335975-m6lkrehi 4801 17 as as IN cord-335975-m6lkrehi 4801 18 an an DT cord-335975-m6lkrehi 4801 19 antecedent.• antecedent.• NNP cord-335975-m6lkrehi 4801 20 A a DT cord-335975-m6lkrehi 4801 21 low low JJ cord-335975-m6lkrehi 4801 22 glasgow glasgow NNP cord-335975-m6lkrehi 4801 23 score score NN cord-335975-m6lkrehi 4801 24 at at IN cord-335975-m6lkrehi 4801 25 admission admission NN cord-335975-m6lkrehi 4801 26 . . . cord-335975-m6lkrehi 4802 1 The the DT cord-335975-m6lkrehi 4802 2 presence presence NN cord-335975-m6lkrehi 4802 3 of of IN cord-335975-m6lkrehi 4802 4 a a DT cord-335975-m6lkrehi 4802 5 neurological neurological JJ cord-335975-m6lkrehi 4802 6 deficit deficit NN cord-335975-m6lkrehi 4802 7 _SP cord-335975-m6lkrehi 4802 8 Arterial Arterial NNP cord-335975-m6lkrehi 4802 9 pH pH NNP cord-335975-m6lkrehi 4802 10 , , , cord-335975-m6lkrehi 4802 11 mean mean JJ cord-335975-m6lkrehi 4802 12 ( ( -LRB- cord-335975-m6lkrehi 4802 13 SD sd NN cord-335975-m6lkrehi 4802 14 ) ) -RRB- cord-335975-m6lkrehi 4803 1 Arterial arterial JJ cord-335975-m6lkrehi 4803 2 lactate lactate NN cord-335975-m6lkrehi 4803 3 , , , cord-335975-m6lkrehi 4803 4 mean mean VB cord-335975-m6lkrehi 4804 1 ( ( -LRB- cord-335975-m6lkrehi 4804 2 SD SD NNP cord-335975-m6lkrehi 4804 3 ) ) -RRB- cord-335975-m6lkrehi 4804 4 Kidney Kidney NNP cord-335975-m6lkrehi 4804 5 Disease Disease NNP cord-335975-m6lkrehi 4804 6 - - HYPH cord-335975-m6lkrehi 4804 7 Improving improve VBG cord-335975-m6lkrehi 4805 1 Global Global NNP cord-335975-m6lkrehi 4805 2 Outcomes Outcomes NNP cord-335975-m6lkrehi 4805 3 Chronic Chronic NNP cord-335975-m6lkrehi 4805 4 Kidney kidney NN cord-335975-m6lkrehi 4805 5 Disease Disease NNP cord-335975-m6lkrehi 4805 6 Guideline Guideline NNP cord-335975-m6lkrehi 4805 7 Development Development NNP cord-335975-m6lkrehi 4805 8 Work Work NNP cord-335975-m6lkrehi 4805 9 Group Group NNP cord-335975-m6lkrehi 4805 10 Members Members NNPS cord-335975-m6lkrehi 4805 11 . . . cord-335975-m6lkrehi 4806 1 Evaluation evaluation NN cord-335975-m6lkrehi 4806 2 and and CC cord-335975-m6lkrehi 4806 3 management management NN cord-335975-m6lkrehi 4806 4 of of IN cord-335975-m6lkrehi 4806 5 chronic chronic JJ cord-335975-m6lkrehi 4806 6 kidney kidney NN cord-335975-m6lkrehi 4806 7 disease disease NN cord-335975-m6lkrehi 4806 8 - - HYPH cord-335975-m6lkrehi 4806 9 synopsis synopsis NN cord-335975-m6lkrehi 4806 10 of of IN cord-335975-m6lkrehi 4806 11 the the DT cord-335975-m6lkrehi 4806 12 kidney kidney NN cord-335975-m6lkrehi 4806 13 disease disease NN cord-335975-m6lkrehi 4806 14 - - HYPH cord-335975-m6lkrehi 4806 15 improving improve VBG cord-335975-m6lkrehi 4806 16 global global JJ cord-335975-m6lkrehi 4806 17 outcomes outcome NNS cord-335975-m6lkrehi 4806 18 2012 2012 CD cord-335975-m6lkrehi 4806 19 clinical clinical JJ cord-335975-m6lkrehi 4806 20 practice practice NN cord-335975-m6lkrehi 4806 21 guideline guideline NN cord-335975-m6lkrehi 4807 1 Dramatic dramatic JJ cord-335975-m6lkrehi 4807 2 increase increase NN cord-335975-m6lkrehi 4807 3 in in IN cord-335975-m6lkrehi 4807 4 venous venous JJ cord-335975-m6lkrehi 4807 5 thromboembolism thromboembolism NN cord-335975-m6lkrehi 4807 6 in in IN cord-335975-m6lkrehi 4807 7 children child NNS cord-335975-m6lkrehi 4807 8 's 's POS cord-335975-m6lkrehi 4807 9 hospitals hospital NNS cord-335975-m6lkrehi 4807 10 in in IN cord-335975-m6lkrehi 4807 11 the the DT cord-335975-m6lkrehi 4807 12 United United NNP cord-335975-m6lkrehi 4807 13 States States NNP cord-335975-m6lkrehi 4807 14 from from IN cord-335975-m6lkrehi 4807 15 Antithrombotic antithrombotic JJ cord-335975-m6lkrehi 4807 16 therapy therapy NN cord-335975-m6lkrehi 4807 17 in in IN cord-335975-m6lkrehi 4807 18 neonates neonate NNS cord-335975-m6lkrehi 4807 19 and and CC cord-335975-m6lkrehi 4807 20 children child NNS cord-335975-m6lkrehi 4807 21 Acute acute JJ cord-335975-m6lkrehi 4807 22 childhood childhood NN cord-335975-m6lkrehi 4807 23 arterial arterial JJ cord-335975-m6lkrehi 4807 24 ischemic ischemic JJ cord-335975-m6lkrehi 4807 25 and and CC cord-335975-m6lkrehi 4807 26 hemorrhagic hemorrhagic JJ cord-335975-m6lkrehi 4807 27 stroke stroke NN cord-335975-m6lkrehi 4807 28 in in IN cord-335975-m6lkrehi 4807 29 the the DT cord-335975-m6lkrehi 4807 30 emergency emergency NN cord-335975-m6lkrehi 4807 31 department department NN cord-335975-m6lkrehi 4807 32 Childhood Childhood NNP cord-335975-m6lkrehi 4807 33 hemorrhagic hemorrhagic JJ cord-335975-m6lkrehi 4807 34 stroke stroke NN cord-335975-m6lkrehi 4807 35 - - : cord-335975-m6lkrehi 4807 36 an an DT cord-335975-m6lkrehi 4807 37 important important JJ cord-335975-m6lkrehi 4807 38 but but CC cord-335975-m6lkrehi 4807 39 understudied understudied JJ cord-335975-m6lkrehi 4807 40 problem problem NN cord-335975-m6lkrehi 4807 41 Emergency Emergency NNP cord-335975-m6lkrehi 4807 42 management management NN cord-335975-m6lkrehi 4807 43 of of IN cord-335975-m6lkrehi 4807 44 deeply deeply RB cord-335975-m6lkrehi 4807 45 comatose comatose JJ cord-335975-m6lkrehi 4807 46 children child NNS cord-335975-m6lkrehi 4807 47 with with IN cord-335975-m6lkrehi 4807 48 acute acute JJ cord-335975-m6lkrehi 4807 49 rupture rupture NN cord-335975-m6lkrehi 4807 50 of of IN cord-335975-m6lkrehi 4807 51 a a DT cord-335975-m6lkrehi 4807 52 cerebral cerebral JJ cord-335975-m6lkrehi 4807 53 arteriovenous arteriovenous JJ cord-335975-m6lkrehi 4807 54 malformation malformation NN cord-335975-m6lkrehi 4807 55 Goulmane Goulmane NNP cord-335975-m6lkrehi 4807 56 Mourad Mourad NNP cord-335975-m6lkrehi 4807 57 -m.goulmane@hotmail.com -m.goulmane@hotmail.com ADD cord-335975-m6lkrehi 4807 58 Annals Annals NNP cord-335975-m6lkrehi 4807 59 of of IN cord-335975-m6lkrehi 4807 60 Intensive Intensive NNP cord-335975-m6lkrehi 4807 61 Care Care NNP cord-335975-m6lkrehi 4808 1 We -PRON- PRP cord-335975-m6lkrehi 4808 2 recorded record VBD cord-335975-m6lkrehi 4808 3 91 91 CD cord-335975-m6lkrehi 4808 4 episodes episode NNS cord-335975-m6lkrehi 4808 5 of of IN cord-335975-m6lkrehi 4808 6 nosocomial nosocomial JJ cord-335975-m6lkrehi 4808 7 infections infection NNS cord-335975-m6lkrehi 4808 8 - - : cord-335975-m6lkrehi 4808 9 pneumonia pneumonia NN cord-335975-m6lkrehi 4809 1 ( ( -LRB- cord-335975-m6lkrehi 4809 2 n n NN cord-335975-m6lkrehi 4809 3 = = SYM cord-335975-m6lkrehi 4809 4 45 45 CD cord-335975-m6lkrehi 4809 5 , , , cord-335975-m6lkrehi 4809 6 49.5 49.5 CD cord-335975-m6lkrehi 4809 7 % % NN cord-335975-m6lkrehi 4809 8 ) ) -RRB- cord-335975-m6lkrehi 4809 9 , , , cord-335975-m6lkrehi 4809 10 bacteremia bacteremia NN cord-335975-m6lkrehi 4809 11 ( ( -LRB- cord-335975-m6lkrehi 4809 12 n n NN cord-335975-m6lkrehi 4809 13 = = SYM cord-335975-m6lkrehi 4809 14 26 26 CD cord-335975-m6lkrehi 4809 15 , , , cord-335975-m6lkrehi 4809 16 28.6 28.6 CD cord-335975-m6lkrehi 4809 17 % % NN cord-335975-m6lkrehi 4809 18 ) ) -RRB- cord-335975-m6lkrehi 4809 19 , , , cord-335975-m6lkrehi 4809 20 catheter catheter NN cord-335975-m6lkrehi 4809 21 related relate VBN cord-335975-m6lkrehi 4809 22 infections infection NNS cord-335975-m6lkrehi 4809 23 CRI CRI NNP cord-335975-m6lkrehi 4809 24 ( ( -LRB- cord-335975-m6lkrehi 4809 25 n n NN cord-335975-m6lkrehi 4809 26 = = SYM cord-335975-m6lkrehi 4809 27 13 13 CD cord-335975-m6lkrehi 4809 28 , , , cord-335975-m6lkrehi 4809 29 14.3 14.3 CD cord-335975-m6lkrehi 4809 30 % % NN cord-335975-m6lkrehi 4809 31 ) ) -RRB- cord-335975-m6lkrehi 4809 32 and and CC cord-335975-m6lkrehi 4809 33 urinary urinary JJ cord-335975-m6lkrehi 4809 34 infections infection NNS cord-335975-m6lkrehi 4809 35 ( ( -LRB- cord-335975-m6lkrehi 4809 36 n n NN cord-335975-m6lkrehi 4809 37 = = SYM cord-335975-m6lkrehi 4809 38 7 7 CD cord-335975-m6lkrehi 4809 39 , , , cord-335975-m6lkrehi 4809 40 7.6 7.6 CD cord-335975-m6lkrehi 4809 41 % % NN cord-335975-m6lkrehi 4809 42 ) ) -RRB- cord-335975-m6lkrehi 4809 43 . . . cord-335975-m6lkrehi 4810 1 Pathogens pathogen NNS cord-335975-m6lkrehi 4810 2 isolated isolate VBN cord-335975-m6lkrehi 4810 3 were be VBD cord-335975-m6lkrehi 4810 4 largely largely RB cord-335975-m6lkrehi 4810 5 dominated dominate VBN cord-335975-m6lkrehi 4810 6 by by IN cord-335975-m6lkrehi 4810 7 non non JJ cord-335975-m6lkrehi 4810 8 - - JJ cord-335975-m6lkrehi 4810 9 fermentent fermentent JJ cord-335975-m6lkrehi 4810 10 Gram gram NN cord-335975-m6lkrehi 4810 11 - - HYPH cord-335975-m6lkrehi 4810 12 negative negative JJ cord-335975-m6lkrehi 4810 13 bacilli bacilli NN cord-335975-m6lkrehi 4810 14 ( ( -LRB- cord-335975-m6lkrehi 4810 15 n n NN cord-335975-m6lkrehi 4810 16 = = SYM cord-335975-m6lkrehi 4810 17 55 55 CD cord-335975-m6lkrehi 4810 18 , , , cord-335975-m6lkrehi 4810 19 60.4%)-Acinetobacter 60.4%)-Acinetobacter NNP cord-335975-m6lkrehi 4810 20 Baumanii Baumanii NNP cord-335975-m6lkrehi 4810 21 ( ( -LRB- cord-335975-m6lkrehi 4810 22 n n NN cord-335975-m6lkrehi 4810 23 = = SYM cord-335975-m6lkrehi 4810 24 39 39 CD cord-335975-m6lkrehi 4810 25 , , , cord-335975-m6lkrehi 4810 26 42.8 42.8 CD cord-335975-m6lkrehi 4810 27 % % NN cord-335975-m6lkrehi 4810 28 ) ) -RRB- cord-335975-m6lkrehi 4810 29 with with IN cord-335975-m6lkrehi 4810 30 100 100 CD cord-335975-m6lkrehi 4810 31 % % NN cord-335975-m6lkrehi 4810 32 resistance resistance NN cord-335975-m6lkrehi 4810 33 to to IN cord-335975-m6lkrehi 4810 34 imipenem imipenem NNP cord-335975-m6lkrehi 4810 35 and and CC cord-335975-m6lkrehi 4810 36 tygecycline tygecycline NNP cord-335975-m6lkrehi 4810 37 , , , cord-335975-m6lkrehi 4810 38 Pseudomonas Pseudomonas NNP cord-335975-m6lkrehi 4810 39 aeruginosa aeruginosa NN cord-335975-m6lkrehi 4810 40 ( ( -LRB- cord-335975-m6lkrehi 4810 41 n n NN cord-335975-m6lkrehi 4810 42 = = SYM cord-335975-m6lkrehi 4810 43 14 14 CD cord-335975-m6lkrehi 4810 44 , , , cord-335975-m6lkrehi 4810 45 15.4 15.4 CD cord-335975-m6lkrehi 4810 46 % % NN cord-335975-m6lkrehi 4810 47 ) ) -RRB- cord-335975-m6lkrehi 4810 48 with with IN cord-335975-m6lkrehi 4810 49 33.3 33.3 CD cord-335975-m6lkrehi 4810 50 % % NN cord-335975-m6lkrehi 4810 51 resistance resistance NN cord-335975-m6lkrehi 4810 52 to to IN cord-335975-m6lkrehi 4810 53 ceftazidim ceftazidim NNP cord-335975-m6lkrehi 4810 54 and and CC cord-335975-m6lkrehi 4810 55 stenotrophomonas stenotrophomonas NNP cord-335975-m6lkrehi 4810 56 maltophila maltophila NNP cord-335975-m6lkrehi 4811 1 ( ( -LRB- cord-335975-m6lkrehi 4811 2 n n NN cord-335975-m6lkrehi 4811 3 = = SYM cord-335975-m6lkrehi 4811 4 2 2 CD cord-335975-m6lkrehi 4811 5 ) ) -RRB- cord-335975-m6lkrehi 4811 6 . . . cord-335975-m6lkrehi 4812 1 Other other JJ cord-335975-m6lkrehi 4812 2 Gram gram NN cord-335975-m6lkrehi 4812 3 - - HYPH cord-335975-m6lkrehi 4812 4 negative negative JJ cord-335975-m6lkrehi 4812 5 bacilli bacilli NN cord-335975-m6lkrehi 4812 6 were be VBD cord-335975-m6lkrehi 4812 7 enterobacteries enterobacterie NNS cord-335975-m6lkrehi 4812 8 ( ( -LRB- cord-335975-m6lkrehi 4812 9 n n NN cord-335975-m6lkrehi 4812 10 = = SYM cord-335975-m6lkrehi 4812 11 11 11 CD cord-335975-m6lkrehi 4812 12 ) ) -RRB- cord-335975-m6lkrehi 4812 13 , , , cord-335975-m6lkrehi 4812 14 which which WDT cord-335975-m6lkrehi 4812 15 were be VBD cord-335975-m6lkrehi 4812 16 wide wide JJ cord-335975-m6lkrehi 4812 17 - - HYPH cord-335975-m6lkrehi 4812 18 spectrum spectrum NN cord-335975-m6lkrehi 4812 19 betalactamase betalactamase NN cord-335975-m6lkrehi 4812 20 secreting secreting NN cord-335975-m6lkrehi 4812 21 ( ( -LRB- cord-335975-m6lkrehi 4812 22 n n NN cord-335975-m6lkrehi 4812 23 = = SYM cord-335975-m6lkrehi 4812 24 6 6 CD cord-335975-m6lkrehi 4812 25 ) ) -RRB- cord-335975-m6lkrehi 4812 26 and and CC cord-335975-m6lkrehi 4812 27 carbapenemase carbapenemase NNP cord-335975-m6lkrehi 4812 28 ( ( -LRB- cord-335975-m6lkrehi 4812 29 n n NN cord-335975-m6lkrehi 4812 30 = = SYM cord-335975-m6lkrehi 4812 31 1 1 CD cord-335975-m6lkrehi 4812 32 ) ) -RRB- cord-335975-m6lkrehi 4812 33 . . . cord-335975-m6lkrehi 4813 1 Gram gram NN cord-335975-m6lkrehi 4813 2 - - HYPH cord-335975-m6lkrehi 4813 3 positive positive JJ cord-335975-m6lkrehi 4813 4 cocci coccus NNS cord-335975-m6lkrehi 4813 5 were be VBD cord-335975-m6lkrehi 4813 6 the the DT cord-335975-m6lkrehi 4813 7 second second JJ cord-335975-m6lkrehi 4813 8 highest high JJS cord-335975-m6lkrehi 4813 9 ( ( -LRB- cord-335975-m6lkrehi 4813 10 n n NN cord-335975-m6lkrehi 4813 11 = = SYM cord-335975-m6lkrehi 4813 12 22 22 CD cord-335975-m6lkrehi 4813 13 , , , cord-335975-m6lkrehi 4813 14 24.2%)-coagulase 24.2%)-coagulase CD cord-335975-m6lkrehi 4813 15 negative negative JJ cord-335975-m6lkrehi 4813 16 Staphylococcus Staphylococcus NNP cord-335975-m6lkrehi 4813 17 ( ( -LRB- cord-335975-m6lkrehi 4813 18 n n NN cord-335975-m6lkrehi 4813 19 = = SYM cord-335975-m6lkrehi 4813 20 12 12 CD cord-335975-m6lkrehi 4813 21 ) ) -RRB- cord-335975-m6lkrehi 4813 22 which which WDT cord-335975-m6lkrehi 4813 23 were be VBD cord-335975-m6lkrehi 4813 24 resistant resistant JJ cord-335975-m6lkrehi 4813 25 to to TO cord-335975-m6lkrehi 4813 26 methicilline methicilline VB cord-335975-m6lkrehi 4813 27 ( ( -LRB- cord-335975-m6lkrehi 4813 28 75 75 CD cord-335975-m6lkrehi 4813 29 % % NN cord-335975-m6lkrehi 4813 30 ) ) -RRB- cord-335975-m6lkrehi 4813 31 , , , cord-335975-m6lkrehi 4813 32 enterococcus enterococcus NNP cord-335975-m6lkrehi 4813 33 ( ( -LRB- cord-335975-m6lkrehi 4813 34 n n NN cord-335975-m6lkrehi 4813 35 = = SYM cord-335975-m6lkrehi 4813 36 7 7 CD cord-335975-m6lkrehi 4813 37 ) ) -RRB- cord-335975-m6lkrehi 4813 38 which which WDT cord-335975-m6lkrehi 4813 39 were be VBD cord-335975-m6lkrehi 4813 40 resistant resistant JJ cord-335975-m6lkrehi 4813 41 to to IN cord-335975-m6lkrehi 4813 42 vancomycin vancomycin FW cord-335975-m6lkrehi 4813 43 ( ( -LRB- cord-335975-m6lkrehi 4813 44 n n NN cord-335975-m6lkrehi 4813 45 = = SYM cord-335975-m6lkrehi 4813 46 2 2 CD cord-335975-m6lkrehi 4813 47 , , , cord-335975-m6lkrehi 4813 48 28.6 28.6 CD cord-335975-m6lkrehi 4813 49 % % NN cord-335975-m6lkrehi 4813 50 ) ) -RRB- cord-335975-m6lkrehi 4813 51 , , , cord-335975-m6lkrehi 4813 52 Staphylococcus Staphylococcus NNP cord-335975-m6lkrehi 4813 53 aureus aureus NN cord-335975-m6lkrehi 4813 54 sensitive sensitive JJ cord-335975-m6lkrehi 4813 55 to to IN cord-335975-m6lkrehi 4813 56 methicilline methicilline NNP cord-335975-m6lkrehi 4813 57 ( ( -LRB- cord-335975-m6lkrehi 4813 58 n n NN cord-335975-m6lkrehi 4813 59 = = SYM cord-335975-m6lkrehi 4813 60 2 2 CD cord-335975-m6lkrehi 4813 61 ) ) -RRB- cord-335975-m6lkrehi 4813 62 and and CC cord-335975-m6lkrehi 4813 63 streptococcus streptococcus NN cord-335975-m6lkrehi 4813 64 ( ( -LRB- cord-335975-m6lkrehi 4813 65 n n NN cord-335975-m6lkrehi 4813 66 = = SYM cord-335975-m6lkrehi 4813 67 1 1 CD cord-335975-m6lkrehi 4813 68 ) ) -RRB- cord-335975-m6lkrehi 4813 69 . . . cord-335975-m6lkrehi 4814 1 Candida Candida NNP cord-335975-m6lkrehi 4814 2 was be VBD cord-335975-m6lkrehi 4814 3 incriminated incriminate VBN cord-335975-m6lkrehi 4814 4 in in IN cord-335975-m6lkrehi 4814 5 2 2 CD cord-335975-m6lkrehi 4814 6 cases case NNS cord-335975-m6lkrehi 4814 7 of of IN cord-335975-m6lkrehi 4814 8 CRI cri NN cord-335975-m6lkrehi 4815 1 We -PRON- PRP cord-335975-m6lkrehi 4815 2 report report VBP cord-335975-m6lkrehi 4815 3 here here RB cord-335975-m6lkrehi 4815 4 that that IN cord-335975-m6lkrehi 4815 5 neonates neonate NNS cord-335975-m6lkrehi 4815 6 had have VBD cord-335975-m6lkrehi 4815 7 a a DT cord-335975-m6lkrehi 4815 8 reduction reduction NN cord-335975-m6lkrehi 4815 9 in in IN cord-335975-m6lkrehi 4815 10 HLA HLA NNP cord-335975-m6lkrehi 4815 11 - - HYPH cord-335975-m6lkrehi 4815 12 DR DR NNP cord-335975-m6lkrehi 4815 13 expression expression NN cord-335975-m6lkrehi 4815 14 after after IN cord-335975-m6lkrehi 4815 15 CPB CPB NNP cord-335975-m6lkrehi 4815 16 , , , cord-335975-m6lkrehi 4815 17 and and CC cord-335975-m6lkrehi 4815 18 those those DT cord-335975-m6lkrehi 4815 19 with with IN cord-335975-m6lkrehi 4815 20 prolonged prolonged JJ cord-335975-m6lkrehi 4815 21 decreased decrease VBD cord-335975-m6lkrehi 4815 22 HLA HLA NNP cord-335975-m6lkrehi 4815 23 - - HYPH cord-335975-m6lkrehi 4815 24 DR DR NNP cord-335975-m6lkrehi 4815 25 in in IN cord-335975-m6lkrehi 4815 26 the the DT cord-335975-m6lkrehi 4815 27 early early JJ cord-335975-m6lkrehi 4815 28 postoperative postoperative JJ cord-335975-m6lkrehi 4815 29 period period NN cord-335975-m6lkrehi 4815 30 ( ( -LRB- cord-335975-m6lkrehi 4815 31 Day day NN cord-335975-m6lkrehi 4815 32 4 4 CD cord-335975-m6lkrehi 4815 33 ) ) -RRB- cord-335975-m6lkrehi 4815 34 could could MD cord-335975-m6lkrehi 4815 35 represent represent VB cord-335975-m6lkrehi 4815 36 a a DT cord-335975-m6lkrehi 4815 37 subpopulation subpopulation NN cord-335975-m6lkrehi 4815 38 at at IN cord-335975-m6lkrehi 4815 39 greatly greatly RB cord-335975-m6lkrehi 4815 40 increased increase VBN cord-335975-m6lkrehi 4815 41 risk risk NN cord-335975-m6lkrehi 4815 42 of of IN cord-335975-m6lkrehi 4815 43 later later RB cord-335975-m6lkrehi 4815 44 NI NI NNP cord-335975-m6lkrehi 4815 45 . . . cord-335975-m6lkrehi 4816 1 If if IN cord-335975-m6lkrehi 4816 2 confirmed confirm VBN cord-335975-m6lkrehi 4816 3 in in IN cord-335975-m6lkrehi 4816 4 a a DT cord-335975-m6lkrehi 4816 5 larger large JJR cord-335975-m6lkrehi 4816 6 cohort cohort NN cord-335975-m6lkrehi 4816 7 of of IN cord-335975-m6lkrehi 4816 8 patients patient NNS cord-335975-m6lkrehi 4816 9 , , , cord-335975-m6lkrehi 4816 10 our -PRON- PRP$ cord-335975-m6lkrehi 4816 11 findings finding NNS cord-335975-m6lkrehi 4816 12 could could MD cord-335975-m6lkrehi 4816 13 indicate indicate VB cord-335975-m6lkrehi 4816 14 that that IN cord-335975-m6lkrehi 4816 15 HLA HLA NNP cord-335975-m6lkrehi 4816 16 - - HYPH cord-335975-m6lkrehi 4816 17 DR DR NNP cord-335975-m6lkrehi 4816 18 may may MD cord-335975-m6lkrehi 4816 19 be be VB cord-335975-m6lkrehi 4816 20 a a DT cord-335975-m6lkrehi 4816 21 useful useful JJ cord-335975-m6lkrehi 4816 22 biomarker biomarker NN cord-335975-m6lkrehi 4816 23 of of IN cord-335975-m6lkrehi 4816 24 immunosuppression immunosuppression NN cord-335975-m6lkrehi 4816 25 after after IN cord-335975-m6lkrehi 4816 26 CPB CPB NNP cord-335975-m6lkrehi 4816 27 in in IN cord-335975-m6lkrehi 4816 28 neonates neonate NNS cord-335975-m6lkrehi 4816 29 . . . cord-335975-m6lkrehi 4817 1 Non non JJ cord-335975-m6lkrehi 4817 2 - - JJ cord-335975-m6lkrehi 4817 3 traumatic traumatic JJ cord-335975-m6lkrehi 4817 4 hemorrhagic hemorrhagic JJ cord-335975-m6lkrehi 4817 5 stroke stroke NN cord-335975-m6lkrehi 4817 6 ( ( -LRB- cord-335975-m6lkrehi 4817 7 NTHS NTHS NNP cord-335975-m6lkrehi 4817 8 ) ) -RRB- cord-335975-m6lkrehi 4817 9 in in IN cord-335975-m6lkrehi 4817 10 comatose comatose JJ cord-335975-m6lkrehi 4817 11 children child NNS cord-335975-m6lkrehi 4817 12 : : : cord-335975-m6lkrehi 4817 13 epidemiological epidemiological JJ cord-335975-m6lkrehi 4817 14 features feature NNS cord-335975-m6lkrehi 4817 15 and and CC cord-335975-m6lkrehi 4817 16 clinical clinical JJ cord-335975-m6lkrehi 4817 17 presentation presentation NN cord-335975-m6lkrehi 4818 1 Conclusion conclusion NN cord-335975-m6lkrehi 4818 2 : : : cord-335975-m6lkrehi 4819 1 Compared compare VBN cord-335975-m6lkrehi 4819 2 to to IN cord-335975-m6lkrehi 4819 3 normobaric normobaric NNP cord-335975-m6lkrehi 4819 4 LTOT LTOT NNP cord-335975-m6lkrehi 4819 5 the the DT cord-335975-m6lkrehi 4819 6 FiO FiO NNP cord-335975-m6lkrehi 4819 7 2 2 CD cord-335975-m6lkrehi 4819 8 is be VBZ cord-335975-m6lkrehi 4819 9 lower low JJR cord-335975-m6lkrehi 4819 10 during during IN cord-335975-m6lkrehi 4819 11 NIV NIV NNP cord-335975-m6lkrehi 4819 12 with with IN cord-335975-m6lkrehi 4819 13 the the DT cord-335975-m6lkrehi 4819 14 same same JJ cord-335975-m6lkrehi 4819 15 O2 o2 NN cord-335975-m6lkrehi 4819 16 flow flow NN cord-335975-m6lkrehi 4819 17 . . . cord-335975-m6lkrehi 4820 1 Compensation compensation NN cord-335975-m6lkrehi 4820 2 for for IN cord-335975-m6lkrehi 4820 3 intentional intentional JJ cord-335975-m6lkrehi 4820 4 and and CC cord-335975-m6lkrehi 4820 5 nonintentional nonintentional JJ cord-335975-m6lkrehi 4820 6 leaks leak NNS cord-335975-m6lkrehi 4820 7 and and CC cord-335975-m6lkrehi 4821 1 so so IN cord-335975-m6lkrehi 4821 2 an an DT cord-335975-m6lkrehi 4821 3 increase increase NN cord-335975-m6lkrehi 4821 4 of of IN cord-335975-m6lkrehi 4821 5 air air NN cord-335975-m6lkrehi 4821 6 flow flow NN cord-335975-m6lkrehi 4821 7 despite despite IN cord-335975-m6lkrehi 4821 8 a a DT cord-335975-m6lkrehi 4821 9 constant constant JJ cord-335975-m6lkrehi 4821 10 O2 o2 NN cord-335975-m6lkrehi 4821 11 input input NN cord-335975-m6lkrehi 4821 12 might may MD cord-335975-m6lkrehi 4821 13 explain explain VB cord-335975-m6lkrehi 4821 14 this this DT cord-335975-m6lkrehi 4821 15 . . . cord-335975-m6lkrehi 4822 1 In in IN cord-335975-m6lkrehi 4822 2 intermediate intermediate JJ cord-335975-m6lkrehi 4822 3 care care VBP cord-335975-m6lkrehi 4822 4 the the DT cord-335975-m6lkrehi 4822 5 use use NN cord-335975-m6lkrehi 4822 6 of of IN cord-335975-m6lkrehi 4822 7 HV HV NNP cord-335975-m6lkrehi 4822 8 for for IN cord-335975-m6lkrehi 4822 9 NIV NIV NNP cord-335975-m6lkrehi 4822 10 may may MD cord-335975-m6lkrehi 4822 11 be be VB cord-335975-m6lkrehi 4822 12 interesting interesting JJ cord-335975-m6lkrehi 4822 13 alternative alternative NN cord-335975-m6lkrehi 4822 14 in in IN cord-335975-m6lkrehi 4822 15 which which WDT cord-335975-m6lkrehi 4822 16 case case NN cord-335975-m6lkrehi 4822 17 the the DT cord-335975-m6lkrehi 4822 18 clinician clinician NN cord-335975-m6lkrehi 4822 19 must must MD cord-335975-m6lkrehi 4822 20 keep keep VB cord-335975-m6lkrehi 4822 21 in in IN cord-335975-m6lkrehi 4822 22 mind mind NN cord-335975-m6lkrehi 4822 23 that that IN cord-335975-m6lkrehi 4822 24 the the DT cord-335975-m6lkrehi 4822 25 FiO fio NN cord-335975-m6lkrehi 4822 26 2 2 CD cord-335975-m6lkrehi 4822 27 decreases decrease VBZ cord-335975-m6lkrehi 4822 28 compared compare VBN cord-335975-m6lkrehi 4822 29 to to IN cord-335975-m6lkrehi 4822 30 standard standard JJ cord-335975-m6lkrehi 4822 31 oxygen oxygen NN cord-335975-m6lkrehi 4822 32 therapy therapy NN cord-335975-m6lkrehi 4822 33 . . . cord-335975-m6lkrehi 4823 1 Concerning concern VBG cord-335975-m6lkrehi 4823 2 home home NN cord-335975-m6lkrehi 4823 3 usage usage NN cord-335975-m6lkrehi 4823 4 we -PRON- PRP cord-335975-m6lkrehi 4823 5 hypothesize hypothesize VBP cord-335975-m6lkrehi 4823 6 that that IN cord-335975-m6lkrehi 4823 7 this this DT cord-335975-m6lkrehi 4823 8 partial partial JJ cord-335975-m6lkrehi 4823 9 removal removal NN cord-335975-m6lkrehi 4823 10 of of IN cord-335975-m6lkrehi 4823 11 O2 O2 NNP cord-335975-m6lkrehi 4823 12 treatment treatment NN cord-335975-m6lkrehi 4823 13 could could MD cord-335975-m6lkrehi 4823 14 contribute contribute VB cord-335975-m6lkrehi 4823 15 to to IN cord-335975-m6lkrehi 4823 16 the the DT cord-335975-m6lkrehi 4823 17 poor poor JJ cord-335975-m6lkrehi 4823 18 results result NNS cord-335975-m6lkrehi 4823 19 of of IN cord-335975-m6lkrehi 4823 20 NIV NIV NNP cord-335975-m6lkrehi 4823 21 in in IN cord-335975-m6lkrehi 4823 22 chronic chronic JJ cord-335975-m6lkrehi 4823 23 COPD COPD NNP cord-335975-m6lkrehi 4823 24 . . . cord-335975-m6lkrehi 4824 1 Introduction introduction NN cord-335975-m6lkrehi 4824 2 : : : cord-335975-m6lkrehi 4825 1 In in IN cord-335975-m6lkrehi 4825 2 February February NNP cord-335975-m6lkrehi 4825 3 2016 2016 CD cord-335975-m6lkrehi 4825 4 , , , cord-335975-m6lkrehi 4825 5 we -PRON- PRP cord-335975-m6lkrehi 4825 6 opened open VBD cord-335975-m6lkrehi 4825 7 a a DT cord-335975-m6lkrehi 4825 8 12 12 CD cord-335975-m6lkrehi 4825 9 beds bed NNS cord-335975-m6lkrehi 4825 10 - - : cord-335975-m6lkrehi 4825 11 post post NN cord-335975-m6lkrehi 4825 12 ICU ICU NNP cord-335975-m6lkrehi 4825 13 rehabilitation rehabilitation NN cord-335975-m6lkrehi 4825 14 center center NN cord-335975-m6lkrehi 4825 15 ( ( -LRB- cord-335975-m6lkrehi 4825 16 Service Service NNP cord-335975-m6lkrehi 4825 17 de de IN cord-335975-m6lkrehi 4825 18 Rééducation Rééducation NNP cord-335975-m6lkrehi 4825 19 Post Post NNP cord-335975-m6lkrehi 4825 20 Réanimation Réanimation NNP cord-335975-m6lkrehi 4825 21 , , , cord-335975-m6lkrehi 4825 22 « « '' cord-335975-m6lkrehi 4825 23 SRPR SRPR NNP cord-335975-m6lkrehi 4825 24 » » NNP cord-335975-m6lkrehi 4825 25 ) ) -RRB- cord-335975-m6lkrehi 4825 26 , , , cord-335975-m6lkrehi 4825 27 dedicated dedicate VBN cord-335975-m6lkrehi 4825 28 to to IN cord-335975-m6lkrehi 4825 29 weaning wean VBG cord-335975-m6lkrehi 4825 30 from from IN cord-335975-m6lkrehi 4825 31 mechanical mechanical JJ cord-335975-m6lkrehi 4825 32 ventilation ventilation NN cord-335975-m6lkrehi 4825 33 and and CC cord-335975-m6lkrehi 4825 34 global global JJ cord-335975-m6lkrehi 4825 35 post post JJ cord-335975-m6lkrehi 4825 36 ICU ICU NNP cord-335975-m6lkrehi 4825 37 rehabilitation rehabilitation NN cord-335975-m6lkrehi 4825 38 . . . cord-335975-m6lkrehi 4826 1 Objectives objectives NN cord-335975-m6lkrehi 4826 2 - - HYPH cord-335975-m6lkrehi 4826 3 description description NN cord-335975-m6lkrehi 4826 4 of of IN cord-335975-m6lkrehi 4826 5 the the DT cord-335975-m6lkrehi 4826 6 characteristics characteristic NNS cord-335975-m6lkrehi 4826 7 and and CC cord-335975-m6lkrehi 4826 8 main main JJ cord-335975-m6lkrehi 4826 9 outcomes outcome NNS cord-335975-m6lkrehi 4826 10 of of IN cord-335975-m6lkrehi 4826 11 the the DT cord-335975-m6lkrehi 4826 12 patients patient NNS cord-335975-m6lkrehi 4826 13 admitted admit VBN cord-335975-m6lkrehi 4826 14 over over IN cord-335975-m6lkrehi 4826 15 the the DT cord-335975-m6lkrehi 4826 16 first first JJ cord-335975-m6lkrehi 4826 17 year year NN cord-335975-m6lkrehi 4826 18 of of IN cord-335975-m6lkrehi 4826 19 activity activity NN cord-335975-m6lkrehi 4826 20 . . . cord-335975-m6lkrehi 4827 1 Patients patient NNS cord-335975-m6lkrehi 4827 2 and and CC cord-335975-m6lkrehi 4827 3 methods method NNS cord-335975-m6lkrehi 4827 4 : : : cord-335975-m6lkrehi 4827 5 retrospective retrospective JJ cord-335975-m6lkrehi 4827 6 analysis analysis NN cord-335975-m6lkrehi 4827 7 of of IN cord-335975-m6lkrehi 4827 8 data datum NNS cord-335975-m6lkrehi 4827 9 extracted extract VBN cord-335975-m6lkrehi 4827 10 from from IN cord-335975-m6lkrehi 4827 11 the the DT cord-335975-m6lkrehi 4827 12 medical medical JJ cord-335975-m6lkrehi 4827 13 files file NNS cord-335975-m6lkrehi 4827 14 . . . cord-335975-m6lkrehi 4828 1 Results result NNS cord-335975-m6lkrehi 4828 2 : : : cord-335975-m6lkrehi 4829 1 96 96 CD cord-335975-m6lkrehi 4829 2 patients patient NNS cord-335975-m6lkrehi 4829 3 were be VBD cord-335975-m6lkrehi 4829 4 admitted admit VBN cord-335975-m6lkrehi 4829 5 100 100 CD cord-335975-m6lkrehi 4829 6 times time NNS cord-335975-m6lkrehi 4829 7 in in IN cord-335975-m6lkrehi 4829 8 the the DT cord-335975-m6lkrehi 4829 9 unit unit NN cord-335975-m6lkrehi 4829 10 over over IN cord-335975-m6lkrehi 4829 11 its -PRON- PRP$ cord-335975-m6lkrehi 4829 12 1st 1st JJ cord-335975-m6lkrehi 4829 13 year year NN cord-335975-m6lkrehi 4829 14 , , , cord-335975-m6lkrehi 4829 15 from from IN cord-335975-m6lkrehi 4829 16 34 34 CD cord-335975-m6lkrehi 4829 17 different different JJ cord-335975-m6lkrehi 4829 18 ICUs icu NNS cord-335975-m6lkrehi 4829 19 ( ( -LRB- cord-335975-m6lkrehi 4829 20 median median JJ cord-335975-m6lkrehi 4829 21 duration duration NN cord-335975-m6lkrehi 4829 22 of of IN cord-335975-m6lkrehi 4829 23 stay stay NN cord-335975-m6lkrehi 4829 24 in in IN cord-335975-m6lkrehi 4829 25 the the DT cord-335975-m6lkrehi 4829 26 ICU ICU NNP cord-335975-m6lkrehi 4829 27 38.5 38.5 CD cord-335975-m6lkrehi 4829 28 days day NNS cord-335975-m6lkrehi 4829 29 ( ( -LRB- cord-335975-m6lkrehi 4829 30 IQR IQR NNP cord-335975-m6lkrehi 4829 31 29 29 CD cord-335975-m6lkrehi 4829 32 - - SYM cord-335975-m6lkrehi 4829 33 61 61 CD cord-335975-m6lkrehi 4829 34 ) ) -RRB- cord-335975-m6lkrehi 4829 35 ) ) -RRB- cord-335975-m6lkrehi 4829 36 . . . cord-335975-m6lkrehi 4830 1 86 86 CD cord-335975-m6lkrehi 4830 2 % % NN cord-335975-m6lkrehi 4830 3 were be VBD cord-335975-m6lkrehi 4830 4 ventilated ventilate VBN cord-335975-m6lkrehi 4830 5 ( ( -LRB- cord-335975-m6lkrehi 4830 6 11 11 CD cord-335975-m6lkrehi 4830 7 % % NN cord-335975-m6lkrehi 4830 8 with with IN cord-335975-m6lkrehi 4830 9 NIV NIV NNP cord-335975-m6lkrehi 4830 10 ) ) -RRB- cord-335975-m6lkrehi 4830 11 . . . cord-335975-m6lkrehi 4831 1 85 85 CD cord-335975-m6lkrehi 4831 2 % % NN cord-335975-m6lkrehi 4831 3 had have VBD cord-335975-m6lkrehi 4831 4 a a DT cord-335975-m6lkrehi 4831 5 tracheostomy tracheostomy NN cord-335975-m6lkrehi 4831 6 . . . cord-335975-m6lkrehi 4832 1 64 64 CD cord-335975-m6lkrehi 4832 2 % % NN cord-335975-m6lkrehi 4832 3 had have VBD cord-335975-m6lkrehi 4832 4 ICU ICU NNP cord-335975-m6lkrehi 4832 5 acquired acquire VBN cord-335975-m6lkrehi 4832 6 weakness weakness NN cord-335975-m6lkrehi 4832 7 + + SYM cord-335975-m6lkrehi 4832 8 5 5 CD cord-335975-m6lkrehi 4832 9 % % NN cord-335975-m6lkrehi 4832 10 were be VBD cord-335975-m6lkrehi 4832 11 able able JJ cord-335975-m6lkrehi 4832 12 to to TO cord-335975-m6lkrehi 4832 13 walk walk VB cord-335975-m6lkrehi 4832 14 . . . cord-335975-m6lkrehi 4833 1 An an DT cord-335975-m6lkrehi 4833 2 underlying underlie VBG cord-335975-m6lkrehi 4833 3 chronic chronic JJ cord-335975-m6lkrehi 4833 4 respiratory respiratory JJ cord-335975-m6lkrehi 4833 5 disease disease NN cord-335975-m6lkrehi 4833 6 was be VBD cord-335975-m6lkrehi 4833 7 present present JJ cord-335975-m6lkrehi 4833 8 in in IN cord-335975-m6lkrehi 4833 9 53 53 CD cord-335975-m6lkrehi 4833 10 % % NN cord-335975-m6lkrehi 4833 11 of of IN cord-335975-m6lkrehi 4833 12 cases case NNS cord-335975-m6lkrehi 4833 13 . . . cord-335975-m6lkrehi 4834 1 18 18 CD cord-335975-m6lkrehi 4834 2 % % NN cord-335975-m6lkrehi 4834 3 were be VBD cord-335975-m6lkrehi 4834 4 obese obese JJ cord-335975-m6lkrehi 4834 5 . . . cord-335975-m6lkrehi 4835 1 Difficult difficult JJ cord-335975-m6lkrehi 4835 2 weaning weaning NN cord-335975-m6lkrehi 4835 3 was be VBD cord-335975-m6lkrehi 4835 4 found find VBN cord-335975-m6lkrehi 4835 5 to to TO cord-335975-m6lkrehi 4835 6 have have VB cord-335975-m6lkrehi 4835 7 one one CD cord-335975-m6lkrehi 4835 8 or or CC cord-335975-m6lkrehi 4835 9 several several JJ cord-335975-m6lkrehi 4835 10 respiratory respiratory JJ cord-335975-m6lkrehi 4835 11 components component NNS cord-335975-m6lkrehi 4835 12 in in IN cord-335975-m6lkrehi 4835 13 77 77 CD cord-335975-m6lkrehi 4835 14 % % NN cord-335975-m6lkrehi 4835 15 of of IN cord-335975-m6lkrehi 4835 16 cases case NNS cord-335975-m6lkrehi 4835 17 ( ( -LRB- cord-335975-m6lkrehi 4835 18 including include VBG cord-335975-m6lkrehi 4835 19 20 20 CD cord-335975-m6lkrehi 4835 20 post post NN cord-335975-m6lkrehi 4835 21 surgery surgery NN cord-335975-m6lkrehi 4835 22 diaphragmatic diaphragmatic JJ cord-335975-m6lkrehi 4835 23 paralysis paralysis NN cord-335975-m6lkrehi 4835 24 ) ) -RRB- cord-335975-m6lkrehi 4835 25 , , , cord-335975-m6lkrehi 4835 26 cardiac cardiac NN cord-335975-m6lkrehi 4835 27 in in IN cord-335975-m6lkrehi 4835 28 34 34 CD cord-335975-m6lkrehi 4835 29 % % NN cord-335975-m6lkrehi 4835 30 , , , cord-335975-m6lkrehi 4835 31 neurologic neurologic JJ cord-335975-m6lkrehi 4835 32 in in IN cord-335975-m6lkrehi 4835 33 18 18 CD cord-335975-m6lkrehi 4835 34 % % NN cord-335975-m6lkrehi 4835 35 . . . cord-335975-m6lkrehi 4836 1 Significant significant JJ cord-335975-m6lkrehi 4836 2 complications complication NNS cord-335975-m6lkrehi 4836 3 occured occur VBD cord-335975-m6lkrehi 4836 4 in in IN cord-335975-m6lkrehi 4836 5 60 60 CD cord-335975-m6lkrehi 4836 6 % % NN cord-335975-m6lkrehi 4836 7 of of IN cord-335975-m6lkrehi 4836 8 cases case NNS cord-335975-m6lkrehi 4836 9 . . . cord-335975-m6lkrehi 4837 1 Median median JJ cord-335975-m6lkrehi 4837 2 duration duration NN cord-335975-m6lkrehi 4837 3 of of IN cord-335975-m6lkrehi 4837 4 stay stay NN cord-335975-m6lkrehi 4837 5 was be VBD cord-335975-m6lkrehi 4837 6 19.5 19.5 CD cord-335975-m6lkrehi 4837 7 ( ( -LRB- cord-335975-m6lkrehi 4837 8 12 12 CD cord-335975-m6lkrehi 4837 9 - - SYM cord-335975-m6lkrehi 4837 10 29.5 29.5 CD cord-335975-m6lkrehi 4837 11 ) ) -RRB- cord-335975-m6lkrehi 4837 12 days day NNS cord-335975-m6lkrehi 4837 13 . . . cord-335975-m6lkrehi 4838 1 Ten ten CD cord-335975-m6lkrehi 4838 2 patients patient NNS cord-335975-m6lkrehi 4838 3 died die VBD cord-335975-m6lkrehi 4838 4 in in IN cord-335975-m6lkrehi 4838 5 the the DT cord-335975-m6lkrehi 4838 6 unit unit NN cord-335975-m6lkrehi 4838 7 , , , cord-335975-m6lkrehi 4838 8 13 13 CD cord-335975-m6lkrehi 4838 9 patients patient NNS cord-335975-m6lkrehi 4838 10 were be VBD cord-335975-m6lkrehi 4838 11 re re VBN cord-335975-m6lkrehi 4838 12 - - VBN cord-335975-m6lkrehi 4838 13 transferred transfer VBN cord-335975-m6lkrehi 4838 14 in in IN cord-335975-m6lkrehi 4838 15 the the DT cord-335975-m6lkrehi 4838 16 ICU ICU NNP cord-335975-m6lkrehi 4838 17 , , , cord-335975-m6lkrehi 4838 18 where where WRB cord-335975-m6lkrehi 4838 19 6 6 CD cord-335975-m6lkrehi 4838 20 of of IN cord-335975-m6lkrehi 4838 21 them -PRON- PRP cord-335975-m6lkrehi 4838 22 died die VBD cord-335975-m6lkrehi 4838 23 . . . cord-335975-m6lkrehi 4839 1 Over over IN cord-335975-m6lkrehi 4839 2 half half NN cord-335975-m6lkrehi 4839 3 of of IN cord-335975-m6lkrehi 4839 4 the the DT cord-335975-m6lkrehi 4839 5 patients patient NNS cord-335975-m6lkrehi 4839 6 were be VBD cord-335975-m6lkrehi 4839 7 discharged discharge VBN cord-335975-m6lkrehi 4839 8 at at IN cord-335975-m6lkrehi 4839 9 home home NN cord-335975-m6lkrehi 4839 10 , , , cord-335975-m6lkrehi 4839 11 in in IN cord-335975-m6lkrehi 4839 12 a a DT cord-335975-m6lkrehi 4839 13 rehabilitation rehabilitation NN cord-335975-m6lkrehi 4839 14 unit unit NN cord-335975-m6lkrehi 4839 15 ( ( -LRB- cord-335975-m6lkrehi 4839 16 SSR SSR NNP cord-335975-m6lkrehi 4839 17 ) ) -RRB- cord-335975-m6lkrehi 4839 18 or or CC cord-335975-m6lkrehi 4839 19 in in IN cord-335975-m6lkrehi 4839 20 a a DT cord-335975-m6lkrehi 4839 21 hospital hospital NN cord-335975-m6lkrehi 4839 22 ward ward NN cord-335975-m6lkrehi 4839 23 awaiting await VBG cord-335975-m6lkrehi 4839 24 a a DT cord-335975-m6lkrehi 4839 25 rehabilitation rehabilitation NN cord-335975-m6lkrehi 4839 26 bed bed NN cord-335975-m6lkrehi 4839 27 . . . cord-335975-m6lkrehi 4840 1 The the DT cord-335975-m6lkrehi 4840 2 remaining remain VBG cord-335975-m6lkrehi 4840 3 24 24 CD cord-335975-m6lkrehi 4840 4 % % NN cord-335975-m6lkrehi 4840 5 , , , cord-335975-m6lkrehi 4840 6 that that WDT cord-335975-m6lkrehi 4840 7 still still RB cord-335975-m6lkrehi 4840 8 needed need VBD cord-335975-m6lkrehi 4840 9 some some DT cord-335975-m6lkrehi 4840 10 form form NN cord-335975-m6lkrehi 4840 11 of of IN cord-335975-m6lkrehi 4840 12 medical medical JJ cord-335975-m6lkrehi 4840 13 or or CC cord-335975-m6lkrehi 4840 14 surgical surgical JJ cord-335975-m6lkrehi 4840 15 care care NN cord-335975-m6lkrehi 4840 16 were be VBD cord-335975-m6lkrehi 4840 17 discharged discharge VBN cord-335975-m6lkrehi 4840 18 in in IN cord-335975-m6lkrehi 4840 19 the the DT cord-335975-m6lkrehi 4840 20 ward ward NN cord-335975-m6lkrehi 4840 21 ( ( -LRB- cord-335975-m6lkrehi 4840 22 Fig Fig NNP cord-335975-m6lkrehi 4840 23 1 1 CD cord-335975-m6lkrehi 4840 24 ) ) -RRB- cord-335975-m6lkrehi 4840 25 . . . cord-335975-m6lkrehi 4841 1 In in IN cord-335975-m6lkrehi 4841 2 intention intention NN cord-335975-m6lkrehi 4841 3 to to TO cord-335975-m6lkrehi 4841 4 treat treat VB cord-335975-m6lkrehi 4841 5 , , , cord-335975-m6lkrehi 4841 6 successful successful JJ cord-335975-m6lkrehi 4841 7 weaning weaning NN cord-335975-m6lkrehi 4841 8 from from IN cord-335975-m6lkrehi 4841 9 invasive invasive JJ cord-335975-m6lkrehi 4841 10 ventilation ventilation NN cord-335975-m6lkrehi 4841 11 was be VBD cord-335975-m6lkrehi 4841 12 obtained obtain VBN cord-335975-m6lkrehi 4841 13 in in IN cord-335975-m6lkrehi 4841 14 70 70 CD cord-335975-m6lkrehi 4841 15 % % NN cord-335975-m6lkrehi 4841 16 of of IN cord-335975-m6lkrehi 4841 17 patients patient NNS cord-335975-m6lkrehi 4841 18 . . . cord-335975-m6lkrehi 4842 1 Of of IN cord-335975-m6lkrehi 4842 2 the the DT cord-335975-m6lkrehi 4842 3 patients patient NNS cord-335975-m6lkrehi 4842 4 discharged discharge VBN cord-335975-m6lkrehi 4842 5 alive alive JJ cord-335975-m6lkrehi 4842 6 from from IN cord-335975-m6lkrehi 4842 7 the the DT cord-335975-m6lkrehi 4842 8 unit unit NN cord-335975-m6lkrehi 4842 9 after after IN cord-335975-m6lkrehi 4842 10 completing complete VBG cord-335975-m6lkrehi 4842 11 the the DT cord-335975-m6lkrehi 4842 12 rehabilitation rehabilitation NN cord-335975-m6lkrehi 4842 13 program program NN cord-335975-m6lkrehi 4842 14 ( ( -LRB- cord-335975-m6lkrehi 4842 15 n n NN cord-335975-m6lkrehi 4842 16 = = SYM cord-335975-m6lkrehi 4842 17 74 74 CD cord-335975-m6lkrehi 4842 18 ) ) -RRB- cord-335975-m6lkrehi 4842 19 , , , cord-335975-m6lkrehi 4842 20 60 60 CD cord-335975-m6lkrehi 4842 21 % % NN cord-335975-m6lkrehi 4842 22 were be VBD cord-335975-m6lkrehi 4842 23 completely completely RB cord-335975-m6lkrehi 4842 24 weaned wean VBN cord-335975-m6lkrehi 4842 25 from from IN cord-335975-m6lkrehi 4842 26 mechanical mechanical JJ cord-335975-m6lkrehi 4842 27 ventilation ventilation NN cord-335975-m6lkrehi 4842 28 , , , cord-335975-m6lkrehi 4842 29 35 35 CD cord-335975-m6lkrehi 4842 30 % % NN cord-335975-m6lkrehi 4842 31 were be VBD cord-335975-m6lkrehi 4842 32 discharged discharge VBN cord-335975-m6lkrehi 4842 33 with with IN cord-335975-m6lkrehi 4842 34 NIV NIV NNP cord-335975-m6lkrehi 4842 35 or or CC cord-335975-m6lkrehi 4842 36 CPAP CPAP NNP cord-335975-m6lkrehi 4842 37 + + SYM cord-335975-m6lkrehi 4842 38 4 4 CD cord-335975-m6lkrehi 4842 39 patients patient NNS cord-335975-m6lkrehi 4842 40 ( ( -LRB- cord-335975-m6lkrehi 4842 41 5 5 CD cord-335975-m6lkrehi 4842 42 % % NN cord-335975-m6lkrehi 4842 43 ) ) -RRB- cord-335975-m6lkrehi 4842 44 were be VBD cord-335975-m6lkrehi 4842 45 considered consider VBN cord-335975-m6lkrehi 4842 46 not not RB cord-335975-m6lkrehi 4842 47 weanable weanable JJ cord-335975-m6lkrehi 4842 48 from from IN cord-335975-m6lkrehi 4842 49 invasive invasive JJ cord-335975-m6lkrehi 4842 50 ventilation ventilation NN cord-335975-m6lkrehi 4842 51 + + CC cord-335975-m6lkrehi 4842 52 decanulation decanulation NN cord-335975-m6lkrehi 4842 53 of of IN cord-335975-m6lkrehi 4842 54 tracheostomy tracheostomy NN cord-335975-m6lkrehi 4842 55 was be VBD cord-335975-m6lkrehi 4842 56 obtained obtain VBN cord-335975-m6lkrehi 4842 57 in in IN cord-335975-m6lkrehi 4842 58 82 82 CD cord-335975-m6lkrehi 4842 59 % % NN cord-335975-m6lkrehi 4842 60 of of IN cord-335975-m6lkrehi 4842 61 cases case NNS cord-335975-m6lkrehi 4842 62 + + SYM cord-335975-m6lkrehi 4842 63 87 87 CD cord-335975-m6lkrehi 4842 64 % % NN cord-335975-m6lkrehi 4842 65 of of IN cord-335975-m6lkrehi 4842 66 the the DT cord-335975-m6lkrehi 4842 67 patients patient NNS cord-335975-m6lkrehi 4842 68 could could MD cord-335975-m6lkrehi 4842 69 walk walk VB cord-335975-m6lkrehi 4842 70 . . . cord-335975-m6lkrehi 4843 1 Conclusion conclusion NN cord-335975-m6lkrehi 4843 2 : : : cord-335975-m6lkrehi 4843 3 SRPRs srpr NNS cord-335975-m6lkrehi 4843 4 offer offer VBP cord-335975-m6lkrehi 4843 5 a a DT cord-335975-m6lkrehi 4843 6 new new JJ cord-335975-m6lkrehi 4843 7 concept concept NN cord-335975-m6lkrehi 4843 8 of of IN cord-335975-m6lkrehi 4843 9 care care NN cord-335975-m6lkrehi 4843 10 for for IN cord-335975-m6lkrehi 4843 11 difficult difficult JJ cord-335975-m6lkrehi 4843 12 to to TO cord-335975-m6lkrehi 4843 13 wean wean VB cord-335975-m6lkrehi 4843 14 patients patient NNS cord-335975-m6lkrehi 4843 15 , , , cord-335975-m6lkrehi 4843 16 with with IN cord-335975-m6lkrehi 4843 17 promising promising JJ cord-335975-m6lkrehi 4843 18 Results result NNS cord-335975-m6lkrehi 4843 19 . . . cord-335975-m6lkrehi 4844 1 Introduction introduction NN cord-335975-m6lkrehi 4844 2 : : : cord-335975-m6lkrehi 4845 1 Scarce scarce JJ cord-335975-m6lkrehi 4845 2 data datum NNS cord-335975-m6lkrehi 4845 3 about about IN cord-335975-m6lkrehi 4845 4 patients patient NNS cord-335975-m6lkrehi 4845 5 with with IN cord-335975-m6lkrehi 4845 6 prolonged prolonged JJ cord-335975-m6lkrehi 4845 7 weaning weaning NN cord-335975-m6lkrehi 4845 8 from from IN cord-335975-m6lkrehi 4845 9 the the DT cord-335975-m6lkrehi 4845 10 mechanical mechanical JJ cord-335975-m6lkrehi 4845 11 ventilation ventilation NN cord-335975-m6lkrehi 4845 12 are be VBP cord-335975-m6lkrehi 4845 13 available available JJ cord-335975-m6lkrehi 4845 14 in in IN cord-335975-m6lkrehi 4845 15 the the DT cord-335975-m6lkrehi 4845 16 literature literature NN cord-335975-m6lkrehi 4845 17 . . . cord-335975-m6lkrehi 4846 1 Patients patient NNS cord-335975-m6lkrehi 4846 2 without without IN cord-335975-m6lkrehi 4846 3 successful successful JJ cord-335975-m6lkrehi 4846 4 weaning wean VBG cord-335975-m6lkrehi 4846 5 7 7 CD cord-335975-m6lkrehi 4846 6 days day NNS cord-335975-m6lkrehi 4846 7 after after IN cord-335975-m6lkrehi 4846 8 their -PRON- PRP$ cord-335975-m6lkrehi 4846 9 first first JJ cord-335975-m6lkrehi 4846 10 weaning weaning NN cord-335975-m6lkrehi 4846 11 attempt attempt NN cord-335975-m6lkrehi 4846 12 were be VBD cord-335975-m6lkrehi 4846 13 classified classify VBN cord-335975-m6lkrehi 4846 14 in in IN cord-335975-m6lkrehi 4846 15 the the DT cord-335975-m6lkrehi 4846 16 group group NN cord-335975-m6lkrehi 4846 17 3 3 CD cord-335975-m6lkrehi 4846 18 of of IN cord-335975-m6lkrehi 4846 19 the the DT cord-335975-m6lkrehi 4846 20 Weaning weaning NN cord-335975-m6lkrehi 4846 21 according accord VBG cord-335975-m6lkrehi 4846 22 New New NNP cord-335975-m6lkrehi 4846 23 Definition Definition NNP cord-335975-m6lkrehi 4846 24 ( ( -LRB- cord-335975-m6lkrehi 4846 25 WIND wind NN cord-335975-m6lkrehi 4846 26 ) ) -RRB- cord-335975-m6lkrehi 4846 27 classification classification NN cord-335975-m6lkrehi 4846 28 ( ( -LRB- cord-335975-m6lkrehi 4846 29 1 1 CD cord-335975-m6lkrehi 4846 30 ) ) -RRB- cord-335975-m6lkrehi 4846 31 . . . cord-335975-m6lkrehi 4847 1 We -PRON- PRP cord-335975-m6lkrehi 4847 2 here here RB cord-335975-m6lkrehi 4847 3 describe describe VBP cord-335975-m6lkrehi 4847 4 specific specific JJ cord-335975-m6lkrehi 4847 5 data datum NNS cord-335975-m6lkrehi 4847 6 concerning concern VBG cord-335975-m6lkrehi 4847 7 weaning weaning NN cord-335975-m6lkrehi 4847 8 and and CC cord-335975-m6lkrehi 4847 9 hospital hospital NN cord-335975-m6lkrehi 4847 10 evolution evolution NN cord-335975-m6lkrehi 4847 11 of of IN cord-335975-m6lkrehi 4847 12 group group NN cord-335975-m6lkrehi 4847 13 3 3 CD cord-335975-m6lkrehi 4847 14 patients patient NNS cord-335975-m6lkrehi 4847 15 included include VBN cord-335975-m6lkrehi 4847 16 in in IN cord-335975-m6lkrehi 4847 17 this this DT cord-335975-m6lkrehi 4847 18 prospective prospective JJ cord-335975-m6lkrehi 4847 19 cohort cohort NN cord-335975-m6lkrehi 4847 20 . . . cord-335975-m6lkrehi 4848 1 Among among IN cord-335975-m6lkrehi 4848 2 the the DT cord-335975-m6lkrehi 4848 3 2709 2709 CD cord-335975-m6lkrehi 4848 4 patients patient NNS cord-335975-m6lkrehi 4848 5 included include VBN cord-335975-m6lkrehi 4848 6 in in IN cord-335975-m6lkrehi 4848 7 the the DT cord-335975-m6lkrehi 4848 8 WIND wind NN cord-335975-m6lkrehi 4848 9 study study NN cord-335975-m6lkrehi 4848 10 , , , cord-335975-m6lkrehi 4848 11 235 235 CD cord-335975-m6lkrehi 4848 12 were be VBD cord-335975-m6lkrehi 4848 13 classified classify VBN cord-335975-m6lkrehi 4848 14 in in IN cord-335975-m6lkrehi 4848 15 the the DT cord-335975-m6lkrehi 4848 16 group group NN cord-335975-m6lkrehi 4848 17 3 3 CD cord-335975-m6lkrehi 4848 18 . . . cord-335975-m6lkrehi 4849 1 Additional additional JJ cord-335975-m6lkrehi 4849 2 data datum NNS cord-335975-m6lkrehi 4849 3 concerning concern VBG cord-335975-m6lkrehi 4849 4 comorbidities comorbiditie NNS cord-335975-m6lkrehi 4849 5 , , , cord-335975-m6lkrehi 4849 6 cause cause NN cord-335975-m6lkrehi 4849 7 of of IN cord-335975-m6lkrehi 4849 8 weaning wean VBG cord-335975-m6lkrehi 4849 9 failure failure NN cord-335975-m6lkrehi 4849 10 and and CC cord-335975-m6lkrehi 4849 11 hospital hospital NN cord-335975-m6lkrehi 4849 12 evolution evolution NN cord-335975-m6lkrehi 4849 13 were be VBD cord-335975-m6lkrehi 4849 14 collected collect VBN cord-335975-m6lkrehi 4849 15 for for IN cord-335975-m6lkrehi 4849 16 213 213 CD cord-335975-m6lkrehi 4849 17 ( ( -LRB- cord-335975-m6lkrehi 4849 18 91 91 CD cord-335975-m6lkrehi 4849 19 % % NN cord-335975-m6lkrehi 4849 20 ) ) -RRB- cord-335975-m6lkrehi 4849 21 of of IN cord-335975-m6lkrehi 4849 22 these these DT cord-335975-m6lkrehi 4849 23 235 235 CD cord-335975-m6lkrehi 4849 24 patients patient NNS cord-335975-m6lkrehi 4849 25 . . . cord-335975-m6lkrehi 4850 1 Results result NNS cord-335975-m6lkrehi 4850 2 : : : cord-335975-m6lkrehi 4851 1 These these DT cord-335975-m6lkrehi 4851 2 213 213 CD cord-335975-m6lkrehi 4851 3 patients patient NNS cord-335975-m6lkrehi 4851 4 had have VBD cord-335975-m6lkrehi 4851 5 median median JJ cord-335975-m6lkrehi 4851 6 [ [ -LRB- cord-335975-m6lkrehi 4851 7 interquartile interquartile JJ cord-335975-m6lkrehi 4851 8 range range NN cord-335975-m6lkrehi 4851 9 ] ] -RRB- cord-335975-m6lkrehi 4851 10 duration duration NN cord-335975-m6lkrehi 4851 11 of of IN cord-335975-m6lkrehi 4851 12 invasive invasive JJ cord-335975-m6lkrehi 4851 13 mechanical mechanical JJ cord-335975-m6lkrehi 4851 14 ventilation ventilation NN cord-335975-m6lkrehi 4851 15 of of IN cord-335975-m6lkrehi 4851 16 18 18 CD cord-335975-m6lkrehi 4851 17 [ [ -LRB- cord-335975-m6lkrehi 4851 18 15 15 CD cord-335975-m6lkrehi 4851 19 ] ] -RRB- cord-335975-m6lkrehi 4851 20 [ [ -LRB- cord-335975-m6lkrehi 4851 21 16 16 CD cord-335975-m6lkrehi 4851 22 ] ] -RRB- cord-335975-m6lkrehi 4852 1 [ [ -LRB- cord-335975-m6lkrehi 4852 2 17 17 CD cord-335975-m6lkrehi 4852 3 ] ] -RRB- cord-335975-m6lkrehi 4852 4 [ [ -LRB- cord-335975-m6lkrehi 4852 5 18 18 CD cord-335975-m6lkrehi 4852 6 ] ] -RRB- cord-335975-m6lkrehi 4852 7 [ [ -LRB- cord-335975-m6lkrehi 4852 8 19 19 CD cord-335975-m6lkrehi 4852 9 ] ] -RRB- cord-335975-m6lkrehi 4853 1 [ [ -LRB- cord-335975-m6lkrehi 4853 2 20 20 CD cord-335975-m6lkrehi 4853 3 ] ] -RRB- cord-335975-m6lkrehi 4853 4 [ [ -LRB- cord-335975-m6lkrehi 4853 5 21 21 CD cord-335975-m6lkrehi 4853 6 ] ] -RRB- cord-335975-m6lkrehi 4854 1 [ [ -LRB- cord-335975-m6lkrehi 4854 2 22 22 CD cord-335975-m6lkrehi 4854 3 ] ] -RRB- cord-335975-m6lkrehi 4854 4 [ [ -LRB- cord-335975-m6lkrehi 4854 5 23 23 CD cord-335975-m6lkrehi 4854 6 ] ] -RRB- cord-335975-m6lkrehi 4855 1 [ [ -LRB- cord-335975-m6lkrehi 4855 2 24 24 CD cord-335975-m6lkrehi 4855 3 ] ] -RRB- cord-335975-m6lkrehi 4855 4 [ [ -LRB- cord-335975-m6lkrehi 4855 5 25 25 CD cord-335975-m6lkrehi 4855 6 ] ] -RRB- cord-335975-m6lkrehi 4855 7 [ [ -LRB- cord-335975-m6lkrehi 4855 8 26 26 CD cord-335975-m6lkrehi 4855 9 ] ] -RRB- cord-335975-m6lkrehi 4855 10 [ [ -LRB- cord-335975-m6lkrehi 4855 11 27 27 CD cord-335975-m6lkrehi 4855 12 ] ] -RRB- cord-335975-m6lkrehi 4855 13 [ [ -LRB- cord-335975-m6lkrehi 4855 14 28 28 CD cord-335975-m6lkrehi 4855 15 ] ] -RRB- cord-335975-m6lkrehi 4855 16 days day NNS cord-335975-m6lkrehi 4855 17 and and CC cord-335975-m6lkrehi 4855 18 3 3 CD cord-335975-m6lkrehi 4855 19 [ [ -LRB- cord-335975-m6lkrehi 4855 20 2 2 CD cord-335975-m6lkrehi 4855 21 ] ] -RRB- cord-335975-m6lkrehi 4855 22 [ [ -LRB- cord-335975-m6lkrehi 4855 23 3 3 CD cord-335975-m6lkrehi 4855 24 ] ] -RRB- cord-335975-m6lkrehi 4855 25 [ [ -LRB- cord-335975-m6lkrehi 4855 26 4 4 CD cord-335975-m6lkrehi 4855 27 ] ] -RRB- cord-335975-m6lkrehi 4855 28 separation separation NN cord-335975-m6lkrehi 4855 29 attempts attempt NNS cord-335975-m6lkrehi 4855 30 . . . cord-335975-m6lkrehi 4856 1 Etiology etiology NN cord-335975-m6lkrehi 4856 2 of of IN cord-335975-m6lkrehi 4856 3 ICU ICU NNP cord-335975-m6lkrehi 4856 4 hospitalization hospitalization NN cord-335975-m6lkrehi 4856 5 was be VBD cord-335975-m6lkrehi 4856 6 medical medical JJ cord-335975-m6lkrehi 4856 7 in in IN cord-335975-m6lkrehi 4856 8 171 171 CD cord-335975-m6lkrehi 4856 9 ( ( -LRB- cord-335975-m6lkrehi 4856 10 80 80 CD cord-335975-m6lkrehi 4856 11 % % NN cord-335975-m6lkrehi 4856 12 ) ) -RRB- cord-335975-m6lkrehi 4856 13 . . . cord-335975-m6lkrehi 4857 1 They -PRON- PRP cord-335975-m6lkrehi 4857 2 had have VBD cord-335975-m6lkrehi 4857 3 a a DT cord-335975-m6lkrehi 4857 4 COPD COPD NNP cord-335975-m6lkrehi 4857 5 in in IN cord-335975-m6lkrehi 4857 6 49 49 CD cord-335975-m6lkrehi 4857 7 ( ( -LRB- cord-335975-m6lkrehi 4857 8 23 23 CD cord-335975-m6lkrehi 4857 9 % % NN cord-335975-m6lkrehi 4857 10 ) ) -RRB- cord-335975-m6lkrehi 4857 11 , , , cord-335975-m6lkrehi 4857 12 hearth hearth NN cord-335975-m6lkrehi 4857 13 disease disease NN cord-335975-m6lkrehi 4857 14 in in IN cord-335975-m6lkrehi 4857 15 33 33 CD cord-335975-m6lkrehi 4857 16 ( ( -LRB- cord-335975-m6lkrehi 4857 17 15 15 CD cord-335975-m6lkrehi 4857 18 % % NN cord-335975-m6lkrehi 4857 19 ) ) -RRB- cord-335975-m6lkrehi 4857 20 and and CC cord-335975-m6lkrehi 4857 21 immusoppression immusoppression NN cord-335975-m6lkrehi 4857 22 in in IN cord-335975-m6lkrehi 4857 23 31 31 CD cord-335975-m6lkrehi 4857 24 ( ( -LRB- cord-335975-m6lkrehi 4857 25 15 15 CD cord-335975-m6lkrehi 4857 26 % % NN cord-335975-m6lkrehi 4857 27 ) ) -RRB- cord-335975-m6lkrehi 4857 28 . . . cord-335975-m6lkrehi 4858 1 We -PRON- PRP cord-335975-m6lkrehi 4858 2 noticed notice VBD cord-335975-m6lkrehi 4858 3 a a DT cord-335975-m6lkrehi 4858 4 mean mean NN cord-335975-m6lkrehi 4858 5 SAPS SAPS NNP cord-335975-m6lkrehi 4858 6 II II NNP cord-335975-m6lkrehi 4858 7 of of IN cord-335975-m6lkrehi 4858 8 53 53 CD cord-335975-m6lkrehi 4858 9 ± ± NNP cord-335975-m6lkrehi 4858 10 18 18 CD cord-335975-m6lkrehi 4858 11 , , , cord-335975-m6lkrehi 4858 12 a a DT cord-335975-m6lkrehi 4858 13 mean mean JJ cord-335975-m6lkrehi 4858 14 SOFA sofa NN cord-335975-m6lkrehi 4858 15 D1 d1 NN cord-335975-m6lkrehi 4858 16 of of IN cord-335975-m6lkrehi 4858 17 8 8 CD cord-335975-m6lkrehi 4858 18 ± ± NNP cord-335975-m6lkrehi 4858 19 4 4 CD cord-335975-m6lkrehi 4858 20 and and CC cord-335975-m6lkrehi 4858 21 D3 D3 NNP cord-335975-m6lkrehi 4858 22 of of IN cord-335975-m6lkrehi 4858 23 7 7 CD cord-335975-m6lkrehi 4858 24 ± ± NNP cord-335975-m6lkrehi 4858 25 4 4 CD cord-335975-m6lkrehi 4858 26 . . . cord-335975-m6lkrehi 4859 1 Tracheostomy tracheostomy NN cord-335975-m6lkrehi 4859 2 for for IN cord-335975-m6lkrehi 4859 3 weaning weaning NN cord-335975-m6lkrehi 4859 4 was be VBD cord-335975-m6lkrehi 4859 5 performing perform VBG cord-335975-m6lkrehi 4859 6 in in IN cord-335975-m6lkrehi 4859 7 55 55 CD cord-335975-m6lkrehi 4859 8 ( ( -LRB- cord-335975-m6lkrehi 4859 9 26 26 CD cord-335975-m6lkrehi 4859 10 % % NN cord-335975-m6lkrehi 4859 11 ) ) -RRB- cord-335975-m6lkrehi 4859 12 . . . cord-335975-m6lkrehi 4860 1 At at IN cord-335975-m6lkrehi 4860 2 the the DT cord-335975-m6lkrehi 4860 3 end end NN cord-335975-m6lkrehi 4860 4 of of IN cord-335975-m6lkrehi 4860 5 their -PRON- PRP$ cord-335975-m6lkrehi 4860 6 follow follow NN cord-335975-m6lkrehi 4860 7 - - HYPH cord-335975-m6lkrehi 4860 8 up up NN cord-335975-m6lkrehi 4860 9 , , , cord-335975-m6lkrehi 4860 10 144 144 CD cord-335975-m6lkrehi 4860 11 ( ( -LRB- cord-335975-m6lkrehi 4860 12 68 68 CD cord-335975-m6lkrehi 4860 13 % % NN cord-335975-m6lkrehi 4860 14 ) ) -RRB- cord-335975-m6lkrehi 4860 15 were be VBD cord-335975-m6lkrehi 4860 16 still still RB cord-335975-m6lkrehi 4860 17 alive-44 alive-44 NN cord-335975-m6lkrehi 4860 18 ( ( -LRB- cord-335975-m6lkrehi 4860 19 21 21 CD cord-335975-m6lkrehi 4860 20 % % NN cord-335975-m6lkrehi 4860 21 ) ) -RRB- cord-335975-m6lkrehi 4860 22 were be VBD cord-335975-m6lkrehi 4860 23 still still RB cord-335975-m6lkrehi 4860 24 tracheostomized tracheostomize VBN cord-335975-m6lkrehi 4860 25 , , , cord-335975-m6lkrehi 4860 26 4 4 CD cord-335975-m6lkrehi 4860 27 still still RB cord-335975-m6lkrehi 4860 28 intubated intubate VBN cord-335975-m6lkrehi 4860 29 and and CC cord-335975-m6lkrehi 4860 30 ventilated ventilate VBN cord-335975-m6lkrehi 4860 31 , , , cord-335975-m6lkrehi 4860 32 8 8 CD cord-335975-m6lkrehi 4860 33 ( ( -LRB- cord-335975-m6lkrehi 4860 34 4 4 CD cord-335975-m6lkrehi 4860 35 % % NN cord-335975-m6lkrehi 4860 36 ) ) -RRB- cord-335975-m6lkrehi 4860 37 treated treat VBN cord-335975-m6lkrehi 4860 38 with with IN cord-335975-m6lkrehi 4860 39 VNI VNI NNP cord-335975-m6lkrehi 4860 40 and and CC cord-335975-m6lkrehi 4860 41 88 88 CD cord-335975-m6lkrehi 4860 42 ( ( -LRB- cord-335975-m6lkrehi 4860 43 41 41 CD cord-335975-m6lkrehi 4860 44 % % NN cord-335975-m6lkrehi 4860 45 ) ) -RRB- cord-335975-m6lkrehi 4860 46 were be VBD cord-335975-m6lkrehi 4860 47 extubated extubate VBN cord-335975-m6lkrehi 4860 48 ( ( -LRB- cord-335975-m6lkrehi 4860 49 or or CC cord-335975-m6lkrehi 4860 50 decannulated decannulated JJ cord-335975-m6lkrehi 4860 51 ) ) -RRB- cord-335975-m6lkrehi 4860 52 and and CC cord-335975-m6lkrehi 4860 53 breathed breathe VBD cord-335975-m6lkrehi 4860 54 without without IN cord-335975-m6lkrehi 4860 55 assistance assistance NN cord-335975-m6lkrehi 4860 56 . . . cord-335975-m6lkrehi 4861 1 Among among IN cord-335975-m6lkrehi 4861 2 the the DT cord-335975-m6lkrehi 4861 3 44 44 CD cord-335975-m6lkrehi 4861 4 patients patient NNS cord-335975-m6lkrehi 4861 5 still still RB cord-335975-m6lkrehi 4861 6 tracheostomized tracheostomize VBN cord-335975-m6lkrehi 4861 7 at at IN cord-335975-m6lkrehi 4861 8 the the DT cord-335975-m6lkrehi 4861 9 end end NN cord-335975-m6lkrehi 4861 10 of of IN cord-335975-m6lkrehi 4861 11 the the DT cord-335975-m6lkrehi 4861 12 follow follow NN cord-335975-m6lkrehi 4861 13 - - HYPH cord-335975-m6lkrehi 4861 14 up up NN cord-335975-m6lkrehi 4861 15 , , , cord-335975-m6lkrehi 4861 16 14 14 CD cord-335975-m6lkrehi 4861 17 ( ( -LRB- cord-335975-m6lkrehi 4861 18 32 32 CD cord-335975-m6lkrehi 4861 19 % % NN cord-335975-m6lkrehi 4861 20 ) ) -RRB- cord-335975-m6lkrehi 4861 21 were be VBD cord-335975-m6lkrehi 4861 22 still still RB cord-335975-m6lkrehi 4861 23 ventilated ventilate VBN cord-335975-m6lkrehi 4861 24 ( ( -LRB- cord-335975-m6lkrehi 4861 25 permanently permanently RB cord-335975-m6lkrehi 4861 26 for for IN cord-335975-m6lkrehi 4861 27 8 8 CD cord-335975-m6lkrehi 4861 28 of of IN cord-335975-m6lkrehi 4861 29 them -PRON- PRP cord-335975-m6lkrehi 4861 30 , , , cord-335975-m6lkrehi 4861 31 and and CC cord-335975-m6lkrehi 4861 32 partially partially RB cord-335975-m6lkrehi 4861 33 for for IN cord-335975-m6lkrehi 4861 34 6 6 CD cord-335975-m6lkrehi 4861 35 ) ) -RRB- cord-335975-m6lkrehi 4861 36 and and CC cord-335975-m6lkrehi 4861 37 30 30 CD cord-335975-m6lkrehi 4861 38 ( ( -LRB- cord-335975-m6lkrehi 4861 39 68 68 CD cord-335975-m6lkrehi 4861 40 % % NN cord-335975-m6lkrehi 4861 41 ) ) -RRB- cord-335975-m6lkrehi 4861 42 had have VBD cord-335975-m6lkrehi 4861 43 spontaneous spontaneous JJ cord-335975-m6lkrehi 4861 44 breathing breathing NN cord-335975-m6lkrehi 4861 45 through through IN cord-335975-m6lkrehi 4861 46 their -PRON- PRP$ cord-335975-m6lkrehi 4861 47 tracheostomy tracheostomy NN cord-335975-m6lkrehi 4861 48 . . . cord-335975-m6lkrehi 4862 1 These these DT cord-335975-m6lkrehi 4862 2 patients patient NNS cord-335975-m6lkrehi 4862 3 had have VBD cord-335975-m6lkrehi 4862 4 a a DT cord-335975-m6lkrehi 4862 5 total total JJ cord-335975-m6lkrehi 4862 6 ICU ICU NNP cord-335975-m6lkrehi 4862 7 length length NN cord-335975-m6lkrehi 4862 8 of of IN cord-335975-m6lkrehi 4862 9 stay stay NN cord-335975-m6lkrehi 4862 10 of of IN cord-335975-m6lkrehi 4862 11 30 30 CD cord-335975-m6lkrehi 4862 12 days day NNS cord-335975-m6lkrehi 4862 13 . . . cord-335975-m6lkrehi 4863 1 The the DT cord-335975-m6lkrehi 4863 2 destination destination NN cord-335975-m6lkrehi 4863 3 at at IN cord-335975-m6lkrehi 4863 4 discharge discharge NN cord-335975-m6lkrehi 4863 5 from from IN cord-335975-m6lkrehi 4863 6 the the DT cord-335975-m6lkrehi 4863 7 ICU ICU NNP cord-335975-m6lkrehi 4863 8 is be VBZ cord-335975-m6lkrehi 4863 9 known know VBN cord-335975-m6lkrehi 4863 10 for for IN cord-335975-m6lkrehi 4863 11 only only RB cord-335975-m6lkrehi 4863 12 49 49 CD cord-335975-m6lkrehi 4863 13 of of IN cord-335975-m6lkrehi 4863 14 the the DT cord-335975-m6lkrehi 4863 15 144 144 CD cord-335975-m6lkrehi 4863 16 survivors-24 survivors-24 NNP cord-335975-m6lkrehi 4863 17 ( ( -LRB- cord-335975-m6lkrehi 4863 18 49 49 CD cord-335975-m6lkrehi 4863 19 % % NN cord-335975-m6lkrehi 4863 20 ) ) -RRB- cord-335975-m6lkrehi 4863 21 in in IN cord-335975-m6lkrehi 4863 22 medical medical NNP cord-335975-m6lkrehi 4863 23 ward ward NNP cord-335975-m6lkrehi 4863 24 , , , cord-335975-m6lkrehi 4863 25 15 15 CD cord-335975-m6lkrehi 4863 26 ( ( -LRB- cord-335975-m6lkrehi 4863 27 31 31 CD cord-335975-m6lkrehi 4863 28 % % NN cord-335975-m6lkrehi 4863 29 ) ) -RRB- cord-335975-m6lkrehi 4863 30 in in IN cord-335975-m6lkrehi 4863 31 intermediate intermediate JJ cord-335975-m6lkrehi 4863 32 care care NN cord-335975-m6lkrehi 4863 33 units unit NNS cord-335975-m6lkrehi 4863 34 , , , cord-335975-m6lkrehi 4863 35 4 4 CD cord-335975-m6lkrehi 4863 36 ( ( -LRB- cord-335975-m6lkrehi 4863 37 8 8 CD cord-335975-m6lkrehi 4863 38 % % NN cord-335975-m6lkrehi 4863 39 ) ) -RRB- cord-335975-m6lkrehi 4863 40 in in IN cord-335975-m6lkrehi 4863 41 sub sub JJ cord-335975-m6lkrehi 4863 42 acute acute JJ cord-335975-m6lkrehi 4863 43 care care NN cord-335975-m6lkrehi 4863 44 , , , cord-335975-m6lkrehi 4863 45 3 3 CD cord-335975-m6lkrehi 4863 46 ( ( -LRB- cord-335975-m6lkrehi 4863 47 6 6 CD cord-335975-m6lkrehi 4863 48 % % NN cord-335975-m6lkrehi 4863 49 ) ) -RRB- cord-335975-m6lkrehi 4863 50 in in IN cord-335975-m6lkrehi 4863 51 ICU ICU NNP cord-335975-m6lkrehi 4863 52 and and CC cord-335975-m6lkrehi 4863 53 3 3 CD cord-335975-m6lkrehi 4863 54 in in IN cord-335975-m6lkrehi 4863 55 surgical surgical JJ cord-335975-m6lkrehi 4863 56 ward ward NN cord-335975-m6lkrehi 4863 57 . . . cord-335975-m6lkrehi 4864 1 Conclusion conclusion NN cord-335975-m6lkrehi 4864 2 : : : cord-335975-m6lkrehi 4865 1 A a DT cord-335975-m6lkrehi 4865 2 third third NN cord-335975-m6lkrehi 4865 3 of of IN cord-335975-m6lkrehi 4865 4 the the DT cord-335975-m6lkrehi 4865 5 213 213 CD cord-335975-m6lkrehi 4865 6 patients patient NNS cord-335975-m6lkrehi 4865 7 of of IN cord-335975-m6lkrehi 4865 8 the the DT cord-335975-m6lkrehi 4865 9 WIND wind NN cord-335975-m6lkrehi 4865 10 study study NN cord-335975-m6lkrehi 4865 11 classified classify VBN cord-335975-m6lkrehi 4865 12 in in IN cord-335975-m6lkrehi 4865 13 group group NN cord-335975-m6lkrehi 4865 14 3 3 CD cord-335975-m6lkrehi 4865 15 and and CC cord-335975-m6lkrehi 4865 16 with with IN cord-335975-m6lkrehi 4865 17 available available JJ cord-335975-m6lkrehi 4865 18 additional additional JJ cord-335975-m6lkrehi 4865 19 data datum NNS cord-335975-m6lkrehi 4865 20 died die VBD cord-335975-m6lkrehi 4865 21 in in IN cord-335975-m6lkrehi 4865 22 hospital hospital NN cord-335975-m6lkrehi 4865 23 in in IN cord-335975-m6lkrehi 4865 24 2 2 CD cord-335975-m6lkrehi 4865 25 months month NNS cord-335975-m6lkrehi 4865 26 following follow VBG cord-335975-m6lkrehi 4865 27 intubation intubation NN cord-335975-m6lkrehi 4865 28 . . . cord-335975-m6lkrehi 4866 1 At at IN cord-335975-m6lkrehi 4866 2 the the DT cord-335975-m6lkrehi 4866 3 end end NN cord-335975-m6lkrehi 4866 4 of of IN cord-335975-m6lkrehi 4866 5 the the DT cord-335975-m6lkrehi 4866 6 follow follow NN cord-335975-m6lkrehi 4866 7 - - HYPH cord-335975-m6lkrehi 4866 8 up up NN cord-335975-m6lkrehi 4866 9 , , , cord-335975-m6lkrehi 4866 10 41 41 CD cord-335975-m6lkrehi 4866 11 % % NN cord-335975-m6lkrehi 4866 12 had have VBD cord-335975-m6lkrehi 4866 13 spontaneous spontaneous JJ cord-335975-m6lkrehi 4866 14 breathing breathing NN cord-335975-m6lkrehi 4866 15 without without IN cord-335975-m6lkrehi 4866 16 assistance assistance NN cord-335975-m6lkrehi 4866 17 , , , cord-335975-m6lkrehi 4866 18 and and CC cord-335975-m6lkrehi 4866 19 21 21 CD cord-335975-m6lkrehi 4866 20 % % NN cord-335975-m6lkrehi 4866 21 were be VBD cord-335975-m6lkrehi 4866 22 still still RB cord-335975-m6lkrehi 4866 23 tracheostomized tracheostomize VBN cord-335975-m6lkrehi 4866 24 . . . cord-335975-m6lkrehi 4867 1 Among among IN cord-335975-m6lkrehi 4867 2 these these DT cord-335975-m6lkrehi 4867 3 tracheostomized tracheostomize VBN cord-335975-m6lkrehi 4867 4 patients patient NNS cord-335975-m6lkrehi 4867 5 , , , cord-335975-m6lkrehi 4867 6 one one CD cord-335975-m6lkrehi 4867 7 third third NN cord-335975-m6lkrehi 4867 8 still still RB cord-335975-m6lkrehi 4867 9 required require VBN cord-335975-m6lkrehi 4867 10 mechanical mechanical JJ cord-335975-m6lkrehi 4867 11 ventilation ventilation NN cord-335975-m6lkrehi 4867 12 . . . cord-335975-m6lkrehi 4868 1 ( ( -LRB- cord-335975-m6lkrehi 4868 2 1)-Béduneau 1)-béduneau CD cord-335975-m6lkrehi 4868 3 , , , cord-335975-m6lkrehi 4868 4 G. G. NNP cord-335975-m6lkrehi 4868 5 , , , cord-335975-m6lkrehi 4868 6 Pham Pham NNP cord-335975-m6lkrehi 4868 7 , , , cord-335975-m6lkrehi 4868 8 T. T. NNP cord-335975-m6lkrehi 4868 9 and and CC cord-335975-m6lkrehi 4868 10 co co NN cord-335975-m6lkrehi 4868 11 ( ( -LRB- cord-335975-m6lkrehi 4868 12 2017 2017 CD cord-335975-m6lkrehi 4868 13 ) ) -RRB- cord-335975-m6lkrehi 4868 14 . . . cord-335975-m6lkrehi 4869 1 Epidemiology epidemiology NN cord-335975-m6lkrehi 4869 2 of of IN cord-335975-m6lkrehi 4869 3 weaning wean VBG cord-335975-m6lkrehi 4869 4 outcome outcome NN cord-335975-m6lkrehi 4869 5 according accord VBG cord-335975-m6lkrehi 4869 6 to to IN cord-335975-m6lkrehi 4869 7 a a DT cord-335975-m6lkrehi 4869 8 new new JJ cord-335975-m6lkrehi 4869 9 definition definition NN cord-335975-m6lkrehi 4869 10 . . . cord-335975-m6lkrehi 4870 1 The the DT cord-335975-m6lkrehi 4870 2 WIND wind NN cord-335975-m6lkrehi 4870 3 study study NN cord-335975-m6lkrehi 4870 4 . . . cord-335975-m6lkrehi 4871 1 AJRCCM AJRCCM NNP cord-335975-m6lkrehi 4871 2 , , , cord-335975-m6lkrehi 4871 3 195(6 195(6 CD cord-335975-m6lkrehi 4871 4 ) ) -RRB- cord-335975-m6lkrehi 4871 5 , , , cord-335975-m6lkrehi 4871 6 772 772 CD cord-335975-m6lkrehi 4871 7 - - HYPH cord-335975-m6lkrehi 4871 8 783 783 CD cord-335975-m6lkrehi 4871 9 . . . cord-335975-m6lkrehi 4872 1 Introduction introduction NN cord-335975-m6lkrehi 4872 2 : : : cord-335975-m6lkrehi 4873 1 COPD COPD NNP cord-335975-m6lkrehi 4873 2 patients patient NNS cord-335975-m6lkrehi 4873 3 have have VBP cord-335975-m6lkrehi 4873 4 often often RB cord-335975-m6lkrehi 4873 5 polyglobulia polyglobulia VBN cord-335975-m6lkrehi 4873 6 because because IN cord-335975-m6lkrehi 4873 7 of of IN cord-335975-m6lkrehi 4873 8 associated associate VBN cord-335975-m6lkrehi 4873 9 hypoxemia hypoxemia NN cord-335975-m6lkrehi 4873 10 especially especially RB cord-335975-m6lkrehi 4873 11 in in IN cord-335975-m6lkrehi 4873 12 patients patient NNS cord-335975-m6lkrehi 4873 13 at at IN cord-335975-m6lkrehi 4873 14 the the DT cord-335975-m6lkrehi 4873 15 stage stage NN cord-335975-m6lkrehi 4873 16 of of IN cord-335975-m6lkrehi 4873 17 chronic chronic JJ cord-335975-m6lkrehi 4873 18 respiratory respiratory JJ cord-335975-m6lkrehi 4873 19 failure failure NN cord-335975-m6lkrehi 4873 20 . . . cord-335975-m6lkrehi 4874 1 We -PRON- PRP cord-335975-m6lkrehi 4874 2 recently recently RB cord-335975-m6lkrehi 4874 3 reported report VBD cord-335975-m6lkrehi 4874 4 that that IN cord-335975-m6lkrehi 4874 5 anemia anemia NN cord-335975-m6lkrehi 4874 6 was be VBD cord-335975-m6lkrehi 4874 7 present present JJ cord-335975-m6lkrehi 4874 8 in in IN cord-335975-m6lkrehi 4874 9 36 36 CD cord-335975-m6lkrehi 4874 10 % % NN cord-335975-m6lkrehi 4874 11 of of IN cord-335975-m6lkrehi 4874 12 patients patient NNS cord-335975-m6lkrehi 4874 13 with with IN cord-335975-m6lkrehi 4874 14 severe severe JJ cord-335975-m6lkrehi 4874 15 AECOPD AECOPD NNP cord-335975-m6lkrehi 4874 16 admitted admit VBD cord-335975-m6lkrehi 4874 17 to to IN cord-335975-m6lkrehi 4874 18 ICU ICU NNP cord-335975-m6lkrehi 4874 19 without without IN cord-335975-m6lkrehi 4874 20 impact impact NN cord-335975-m6lkrehi 4874 21 on on IN cord-335975-m6lkrehi 4874 22 short short JJ cord-335975-m6lkrehi 4874 23 - - HYPH cord-335975-m6lkrehi 4874 24 term term NN cord-335975-m6lkrehi 4874 25 prognosis prognosis NN cord-335975-m6lkrehi 4874 26 . . . cord-335975-m6lkrehi 4875 1 The the DT cord-335975-m6lkrehi 4875 2 aim aim NN cord-335975-m6lkrehi 4875 3 of of IN cord-335975-m6lkrehi 4875 4 the the DT cord-335975-m6lkrehi 4875 5 present present JJ cord-335975-m6lkrehi 4875 6 study study NN cord-335975-m6lkrehi 4875 7 was be VBD cord-335975-m6lkrehi 4875 8 to to TO cord-335975-m6lkrehi 4875 9 assess assess VB cord-335975-m6lkrehi 4875 10 the the DT cord-335975-m6lkrehi 4875 11 long long JJ cord-335975-m6lkrehi 4875 12 - - HYPH cord-335975-m6lkrehi 4875 13 term term NN cord-335975-m6lkrehi 4875 14 impact impact NN cord-335975-m6lkrehi 4875 15 of of IN cord-335975-m6lkrehi 4875 16 haemoglobin haemoglobin NN cord-335975-m6lkrehi 4875 17 ( ( -LRB- cord-335975-m6lkrehi 4875 18 Hb Hb NNP cord-335975-m6lkrehi 4875 19 ) ) -RRB- cord-335975-m6lkrehi 4875 20 levels level NNS cord-335975-m6lkrehi 4875 21 on on IN cord-335975-m6lkrehi 4875 22 outcomes outcome NNS cord-335975-m6lkrehi 4875 23 of of IN cord-335975-m6lkrehi 4875 24 AECOPD AECOPD NNP cord-335975-m6lkrehi 4875 25 patients patient NNS cord-335975-m6lkrehi 4875 26 . . . cord-335975-m6lkrehi 4876 1 Patients patient NNS cord-335975-m6lkrehi 4876 2 and and CC cord-335975-m6lkrehi 4876 3 methods method NNS cord-335975-m6lkrehi 4876 4 : : : cord-335975-m6lkrehi 4876 5 In in IN cord-335975-m6lkrehi 4876 6 a a DT cord-335975-m6lkrehi 4876 7 prospectively prospectively RB cord-335975-m6lkrehi 4876 8 collected collect VBN cord-335975-m6lkrehi 4876 9 database database NN cord-335975-m6lkrehi 4876 10 including include VBG cord-335975-m6lkrehi 4876 11 consecutive consecutive JJ cord-335975-m6lkrehi 4876 12 patients patient NNS cord-335975-m6lkrehi 4876 13 admitted admit VBN cord-335975-m6lkrehi 4876 14 between between IN cord-335975-m6lkrehi 4876 15 2007 2007 CD cord-335975-m6lkrehi 4876 16 and and CC cord-335975-m6lkrehi 4876 17 2015 2015 CD cord-335975-m6lkrehi 4876 18 for for IN cord-335975-m6lkrehi 4876 19 AECOPD AECOPD NNP cord-335975-m6lkrehi 4876 20 in in IN cord-335975-m6lkrehi 4876 21 our -PRON- PRP$ cord-335975-m6lkrehi 4876 22 ICU ICU NNP cord-335975-m6lkrehi 4876 23 . . . cord-335975-m6lkrehi 4877 1 Long long JJ cord-335975-m6lkrehi 4877 2 - - HYPH cord-335975-m6lkrehi 4877 3 term term NN cord-335975-m6lkrehi 4877 4 status status NN cord-335975-m6lkrehi 4877 5 of of IN cord-335975-m6lkrehi 4877 6 patients patient NNS cord-335975-m6lkrehi 4877 7 following follow VBG cord-335975-m6lkrehi 4877 8 the the DT cord-335975-m6lkrehi 4877 9 first first JJ cord-335975-m6lkrehi 4877 10 ICU ICU NNP cord-335975-m6lkrehi 4877 11 admission admission NN cord-335975-m6lkrehi 4877 12 ( ( -LRB- cord-335975-m6lkrehi 4877 13 surviving survive VBG cord-335975-m6lkrehi 4877 14 or or CC cord-335975-m6lkrehi 4877 15 deceased deceased JJ cord-335975-m6lkrehi 4877 16 ) ) -RRB- cord-335975-m6lkrehi 4877 17 has have VBZ cord-335975-m6lkrehi 4877 18 been be VBN cord-335975-m6lkrehi 4877 19 verified verify VBN cord-335975-m6lkrehi 4877 20 by by IN cord-335975-m6lkrehi 4877 21 consulting consult VBG cord-335975-m6lkrehi 4877 22 the the DT cord-335975-m6lkrehi 4877 23 civil civil JJ cord-335975-m6lkrehi 4877 24 status status NN cord-335975-m6lkrehi 4877 25 registers register NNS cord-335975-m6lkrehi 4877 26 . . . cord-335975-m6lkrehi 4878 1 Anemia anemia NN cord-335975-m6lkrehi 4878 2 was be VBD cord-335975-m6lkrehi 4878 3 defined define VBN cord-335975-m6lkrehi 4878 4 according accord VBG cord-335975-m6lkrehi 4878 5 to to IN cord-335975-m6lkrehi 4878 6 WHO who WP cord-335975-m6lkrehi 4878 7 criteria criterion NNS cord-335975-m6lkrehi 4878 8 - - : cord-335975-m6lkrehi 4878 9 Hb Hb NNP cord-335975-m6lkrehi 4879 1 < < NNP cord-335975-m6lkrehi 4879 2 13 13 CD cord-335975-m6lkrehi 4879 3 g g NNP cord-335975-m6lkrehi 4879 4 dl dl NN cord-335975-m6lkrehi 4879 5 in in IN cord-335975-m6lkrehi 4879 6 males male NNS cord-335975-m6lkrehi 4879 7 + + CC cord-335975-m6lkrehi 4880 1 Hb Hb NNP cord-335975-m6lkrehi 4880 2 < < XX cord-335975-m6lkrehi 4880 3 12 12 CD cord-335975-m6lkrehi 4880 4 g g NN cord-335975-m6lkrehi 4880 5 dl dl NN cord-335975-m6lkrehi 4880 6 in in IN cord-335975-m6lkrehi 4880 7 females female NNS cord-335975-m6lkrehi 4880 8 . . . cord-335975-m6lkrehi 4881 1 Long long JJ cord-335975-m6lkrehi 4881 2 - - HYPH cord-335975-m6lkrehi 4881 3 term term NN cord-335975-m6lkrehi 4881 4 survival survival NN cord-335975-m6lkrehi 4881 5 was be VBD cord-335975-m6lkrehi 4881 6 assessed assess VBN cord-335975-m6lkrehi 4881 7 by by IN cord-335975-m6lkrehi 4881 8 Kaplan Kaplan NNP cord-335975-m6lkrehi 4881 9 - - HYPH cord-335975-m6lkrehi 4881 10 Meier Meier NNP cord-335975-m6lkrehi 4881 11 curve curve NN cord-335975-m6lkrehi 4881 12 . . . cord-335975-m6lkrehi 4882 1 Results result NNS cord-335975-m6lkrehi 4882 2 : : : cord-335975-m6lkrehi 4883 1 The the DT cord-335975-m6lkrehi 4883 2 cohort cohort NN cord-335975-m6lkrehi 4883 3 included include VBD cord-335975-m6lkrehi 4883 4 213 213 CD cord-335975-m6lkrehi 4883 5 patients patient NNS cord-335975-m6lkrehi 4883 6 ( ( -LRB- cord-335975-m6lkrehi 4883 7 median median JJ cord-335975-m6lkrehi 4883 8 age age NN cord-335975-m6lkrehi 4883 9 67 67 CD cord-335975-m6lkrehi 4883 10 , , , cord-335975-m6lkrehi 4883 11 median median NN cord-335975-m6lkrehi 4883 12 pH pH NNP cord-335975-m6lkrehi 4883 13 7.30 7.30 CD cord-335975-m6lkrehi 4883 14 , , , cord-335975-m6lkrehi 4883 15 84.5 84.5 CD cord-335975-m6lkrehi 4883 16 % % NN cord-335975-m6lkrehi 4883 17 males male NNS cord-335975-m6lkrehi 4883 18 , , , cord-335975-m6lkrehi 4883 19 NIV NIV NNP cord-335975-m6lkrehi 4883 20 as as IN cord-335975-m6lkrehi 4883 21 first first JJ cord-335975-m6lkrehi 4883 22 ventilator ventilator NN cord-335975-m6lkrehi 4883 23 mode mode NN cord-335975-m6lkrehi 4883 24 in in IN cord-335975-m6lkrehi 4883 25 87.4 87.4 CD cord-335975-m6lkrehi 4883 26 % % NN cord-335975-m6lkrehi 4883 27 ) ) -RRB- cord-335975-m6lkrehi 4883 28 . . . cord-335975-m6lkrehi 4884 1 Anemia anemia NN cord-335975-m6lkrehi 4884 2 was be VBD cord-335975-m6lkrehi 4884 3 observed observe VBN cord-335975-m6lkrehi 4884 4 in in IN cord-335975-m6lkrehi 4884 5 77 77 CD cord-335975-m6lkrehi 4884 6 of of IN cord-335975-m6lkrehi 4884 7 the the DT cord-335975-m6lkrehi 4884 8 213 213 CD cord-335975-m6lkrehi 4884 9 patients patient NNS cord-335975-m6lkrehi 4884 10 ( ( -LRB- cord-335975-m6lkrehi 4884 11 36.2 36.2 CD cord-335975-m6lkrehi 4884 12 % % NN cord-335975-m6lkrehi 4884 13 ) ) -RRB- cord-335975-m6lkrehi 4884 14 with with IN cord-335975-m6lkrehi 4884 15 median median JJ cord-335975-m6lkrehi 4884 16 haemoglobin haemoglobin NN cord-335975-m6lkrehi 4884 17 levels level NNS cord-335975-m6lkrehi 4884 18 at at IN cord-335975-m6lkrehi 4884 19 10.8 10.8 CD cord-335975-m6lkrehi 4884 20 and and CC cord-335975-m6lkrehi 4884 21 14.5 14.5 CD cord-335975-m6lkrehi 4884 22 g g NN cord-335975-m6lkrehi 4884 23 dl dl NN cord-335975-m6lkrehi 4884 24 , , , cord-335975-m6lkrehi 4884 25 in in IN cord-335975-m6lkrehi 4884 26 patients patient NNS cord-335975-m6lkrehi 4884 27 with with IN cord-335975-m6lkrehi 4884 28 and and CC cord-335975-m6lkrehi 4884 29 without without IN cord-335975-m6lkrehi 4884 30 anemia anemia NN cord-335975-m6lkrehi 4884 31 , , , cord-335975-m6lkrehi 4884 32 respectively respectively RB cord-335975-m6lkrehi 4884 33 . . . cord-335975-m6lkrehi 4885 1 Anemia anemia NN cord-335975-m6lkrehi 4885 2 was be VBD cord-335975-m6lkrehi 4885 3 associated associate VBN cord-335975-m6lkrehi 4885 4 with with IN cord-335975-m6lkrehi 4885 5 significantly significantly RB cord-335975-m6lkrehi 4885 6 lower low JJR cord-335975-m6lkrehi 4885 7 2 2 CD cord-335975-m6lkrehi 4885 8 years year NNS cord-335975-m6lkrehi 4885 9 survival survival NN cord-335975-m6lkrehi 4885 10 ( ( -LRB- cord-335975-m6lkrehi 4885 11 Log Log NNP cord-335975-m6lkrehi 4885 12 Rank Rank NNP cord-335975-m6lkrehi 4885 13 p p NN cord-335975-m6lkrehi 4885 14 = = SYM cord-335975-m6lkrehi 4885 15 0.043 0.043 CD cord-335975-m6lkrehi 4885 16 ) ) -RRB- cord-335975-m6lkrehi 4886 1 ( ( -LRB- cord-335975-m6lkrehi 4886 2 Fig Fig NNP cord-335975-m6lkrehi 4886 3 . . NNP cord-335975-m6lkrehi 4886 4 1 1 CD cord-335975-m6lkrehi 4886 5 ) ) -RRB- cord-335975-m6lkrehi 4886 6 . . . cord-335975-m6lkrehi 4887 1 The the DT cord-335975-m6lkrehi 4887 2 final final JJ cord-335975-m6lkrehi 4887 3 model model NN cord-335975-m6lkrehi 4887 4 included include VBD cord-335975-m6lkrehi 4887 5 age age NN cord-335975-m6lkrehi 4887 6 , , , cord-335975-m6lkrehi 4887 7 SAPS SAPS NNP cord-335975-m6lkrehi 4887 8 II II NNP cord-335975-m6lkrehi 4887 9 score score NN cord-335975-m6lkrehi 4887 10 , , , cord-335975-m6lkrehi 4887 11 comorbidities comorbiditie NNS cord-335975-m6lkrehi 4887 12 , , , cord-335975-m6lkrehi 4887 13 home home NN cord-335975-m6lkrehi 4887 14 oxygen oxygen NN cord-335975-m6lkrehi 4887 15 therapy therapy NN cord-335975-m6lkrehi 4887 16 , , , cord-335975-m6lkrehi 4887 17 initial initial JJ cord-335975-m6lkrehi 4887 18 ventilatory ventilatory NN cord-335975-m6lkrehi 4887 19 mode mode NN cord-335975-m6lkrehi 4887 20 , , , cord-335975-m6lkrehi 4887 21 NIV NIV NNP cord-335975-m6lkrehi 4887 22 failure failure NN cord-335975-m6lkrehi 4887 23 and and CC cord-335975-m6lkrehi 4887 24 haemoglobin haemoglobin NN cord-335975-m6lkrehi 4887 25 levels level NNS cord-335975-m6lkrehi 4887 26 . . . cord-335975-m6lkrehi 4888 1 Multivariate multivariate JJ cord-335975-m6lkrehi 4888 2 analysis analysis NN cord-335975-m6lkrehi 4888 3 identified identify VBD cord-335975-m6lkrehi 4888 4 age age NN cord-335975-m6lkrehi 4888 5 ( ( -LRB- cord-335975-m6lkrehi 4888 6 OR or CC cord-335975-m6lkrehi 4888 7 1.05 1.05 CD cord-335975-m6lkrehi 4888 8 per per IN cord-335975-m6lkrehi 4888 9 year year NN cord-335975-m6lkrehi 4889 1 + + CC cord-335975-m6lkrehi 4889 2 IC IC NNP cord-335975-m6lkrehi 4889 3 95 95 CD cord-335975-m6lkrehi 4889 4 % % NN cord-335975-m6lkrehi 4889 5 1.01 1.01 CD cord-335975-m6lkrehi 4889 6 - - SYM cord-335975-m6lkrehi 4889 7 1.10 1.10 CD cord-335975-m6lkrehi 4890 1 + + CC cord-335975-m6lkrehi 4890 2 p p NN cord-335975-m6lkrehi 4890 3 = = SYM cord-335975-m6lkrehi 4890 4 0.028 0.028 CD cord-335975-m6lkrehi 4890 5 ) ) -RRB- cord-335975-m6lkrehi 4890 6 , , , cord-335975-m6lkrehi 4890 7 home home NN cord-335975-m6lkrehi 4890 8 oxygen oxygen NN cord-335975-m6lkrehi 4890 9 therapy therapy NN cord-335975-m6lkrehi 4890 10 prior prior RB cord-335975-m6lkrehi 4890 11 to to IN cord-335975-m6lkrehi 4890 12 exacerbation exacerbation NN cord-335975-m6lkrehi 4890 13 ( ( -LRB- cord-335975-m6lkrehi 4890 14 OR or CC cord-335975-m6lkrehi 4890 15 2.38 2.38 CD cord-335975-m6lkrehi 4891 1 + + CC cord-335975-m6lkrehi 4891 2 IC IC NNP cord-335975-m6lkrehi 4891 3 95 95 CD cord-335975-m6lkrehi 4891 4 % % NN cord-335975-m6lkrehi 4891 5 1.09 1.09 CD cord-335975-m6lkrehi 4891 6 - - SYM cord-335975-m6lkrehi 4891 7 5.12 5.12 CD cord-335975-m6lkrehi 4892 1 + + CC cord-335975-m6lkrehi 4892 2 p p NN cord-335975-m6lkrehi 4892 3 = = SYM cord-335975-m6lkrehi 4892 4 0.029 0.029 CD cord-335975-m6lkrehi 4892 5 ) ) -RRB- cord-335975-m6lkrehi 4892 6 , , , cord-335975-m6lkrehi 4892 7 intubation intubation NN cord-335975-m6lkrehi 4892 8 at at IN cord-335975-m6lkrehi 4892 9 ICU ICU NNP cord-335975-m6lkrehi 4892 10 admission admission NN cord-335975-m6lkrehi 4892 11 ( ( -LRB- cord-335975-m6lkrehi 4892 12 OR or RB cord-335975-m6lkrehi 4893 1 6.97 6.97 CD cord-335975-m6lkrehi 4893 2 + + SYM cord-335975-m6lkrehi 4893 3 IC IC NNP cord-335975-m6lkrehi 4893 4 95 95 CD cord-335975-m6lkrehi 4893 5 % % NN cord-335975-m6lkrehi 4893 6 2.31 2.31 CD cord-335975-m6lkrehi 4893 7 - - HYPH cord-335975-m6lkrehi 4893 8 21.03 21.03 CD cord-335975-m6lkrehi 4893 9 + + CC cord-335975-m6lkrehi 4893 10 p p NN cord-335975-m6lkrehi 4893 11 < < XX cord-335975-m6lkrehi 4893 12 0.001 0.001 CD cord-335975-m6lkrehi 4893 13 ) ) -RRB- cord-335975-m6lkrehi 4893 14 , , , cord-335975-m6lkrehi 4893 15 NIV NIV NNP cord-335975-m6lkrehi 4893 16 failure failure NN cord-335975-m6lkrehi 4893 17 ( ( -LRB- cord-335975-m6lkrehi 4893 18 OR or CC cord-335975-m6lkrehi 4894 1 11.5 11.5 CD cord-335975-m6lkrehi 4894 2 + + SYM cord-335975-m6lkrehi 4894 3 IC IC NNP cord-335975-m6lkrehi 4894 4 95 95 CD cord-335975-m6lkrehi 4894 5 % % NN cord-335975-m6lkrehi 4894 6 2.75 2.75 CD cord-335975-m6lkrehi 4894 7 - - HYPH cord-335975-m6lkrehi 4894 8 47.6 47.6 CD cord-335975-m6lkrehi 4894 9 + + CC cord-335975-m6lkrehi 4894 10 p p NN cord-335975-m6lkrehi 4894 11 < < XX cord-335975-m6lkrehi 4894 12 0.001 0.001 CD cord-335975-m6lkrehi 4894 13 ) ) -RRB- cord-335975-m6lkrehi 4894 14 , , , cord-335975-m6lkrehi 4894 15 and and CC cord-335975-m6lkrehi 4894 16 haemoglobin haemoglobin NN cord-335975-m6lkrehi 4894 17 ( ( -LRB- cord-335975-m6lkrehi 4894 18 OR or CC cord-335975-m6lkrehi 4894 19 1.20 1.20 CD cord-335975-m6lkrehi 4894 20 per per IN cord-335975-m6lkrehi 4894 21 decrease decrease NN cord-335975-m6lkrehi 4894 22 of of IN cord-335975-m6lkrehi 4894 23 1 1 CD cord-335975-m6lkrehi 4894 24 g g NN cord-335975-m6lkrehi 4894 25 dl dl NN cord-335975-m6lkrehi 4894 26 + + CC cord-335975-m6lkrehi 4894 27 IC IC NNP cord-335975-m6lkrehi 4894 28 95 95 CD cord-335975-m6lkrehi 4894 29 % % NN cord-335975-m6lkrehi 4894 30 1.01 1.01 CD cord-335975-m6lkrehi 4894 31 - - SYM cord-335975-m6lkrehi 4894 32 1.44 1.44 CD cord-335975-m6lkrehi 4895 1 + + CC cord-335975-m6lkrehi 4895 2 p p NN cord-335975-m6lkrehi 4895 3 = = SYM cord-335975-m6lkrehi 4895 4 0.034 0.034 CD cord-335975-m6lkrehi 4895 5 ) ) -RRB- cord-335975-m6lkrehi 4896 1 as as IN cord-335975-m6lkrehi 4896 2 independently independently RB cord-335975-m6lkrehi 4896 3 associated associate VBN cord-335975-m6lkrehi 4896 4 factors factor NNS cord-335975-m6lkrehi 4896 5 with with IN cord-335975-m6lkrehi 4896 6 2 2 CD cord-335975-m6lkrehi 4896 7 years year NNS cord-335975-m6lkrehi 4896 8 mortality mortality NN cord-335975-m6lkrehi 4896 9 . . . cord-335975-m6lkrehi 4897 1 We -PRON- PRP cord-335975-m6lkrehi 4897 2 conducted conduct VBD cord-335975-m6lkrehi 4897 3 a a DT cord-335975-m6lkrehi 4897 4 prospective prospective JJ cord-335975-m6lkrehi 4897 5 observational observational JJ cord-335975-m6lkrehi 4897 6 study study NN cord-335975-m6lkrehi 4897 7 including include VBG cord-335975-m6lkrehi 4897 8 all all DT cord-335975-m6lkrehi 4897 9 patients patient NNS cord-335975-m6lkrehi 4897 10 who who WP cord-335975-m6lkrehi 4897 11 visited visit VBD cord-335975-m6lkrehi 4897 12 the the DT cord-335975-m6lkrehi 4897 13 SIS SIS NNP cord-335975-m6lkrehi 4897 14 during during IN cord-335975-m6lkrehi 4897 15 the the DT cord-335975-m6lkrehi 4897 16 last last JJ cord-335975-m6lkrehi 4897 17 12 12 CD cord-335975-m6lkrehi 4897 18 months month NNS cord-335975-m6lkrehi 4897 19 . . . cord-335975-m6lkrehi 4898 1 The the DT cord-335975-m6lkrehi 4898 2 collection collection NN cord-335975-m6lkrehi 4898 3 of of IN cord-335975-m6lkrehi 4898 4 the the DT cord-335975-m6lkrehi 4898 5 usual usual JJ cord-335975-m6lkrehi 4898 6 anonymous anonymous JJ cord-335975-m6lkrehi 4898 7 demographic demographic JJ cord-335975-m6lkrehi 4898 8 , , , cord-335975-m6lkrehi 4898 9 medical medical JJ cord-335975-m6lkrehi 4898 10 and and CC cord-335975-m6lkrehi 4898 11 toxicological toxicological JJ cord-335975-m6lkrehi 4898 12 data datum NNS cord-335975-m6lkrehi 4898 13 was be VBD cord-335975-m6lkrehi 4898 14 performed perform VBN cord-335975-m6lkrehi 4898 15 by by IN cord-335975-m6lkrehi 4898 16 the the DT cord-335975-m6lkrehi 4898 17 care care NN cord-335975-m6lkrehi 4898 18 - - HYPH cord-335975-m6lkrehi 4898 19 givers giver NNS cord-335975-m6lkrehi 4898 20 and and CC cord-335975-m6lkrehi 4898 21 social social JJ cord-335975-m6lkrehi 4898 22 workers worker NNS cord-335975-m6lkrehi 4898 23 in in IN cord-335975-m6lkrehi 4898 24 charge charge NN cord-335975-m6lkrehi 4898 25 of of IN cord-335975-m6lkrehi 4898 26 the the DT cord-335975-m6lkrehi 4898 27 drug drug NN cord-335975-m6lkrehi 4898 28 users user NNS cord-335975-m6lkrehi 4898 29 . . . cord-335975-m6lkrehi 4899 1 Data datum NNS cord-335975-m6lkrehi 4899 2 were be VBD cord-335975-m6lkrehi 4899 3 declarative declarative JJ cord-335975-m6lkrehi 4899 4 and and CC cord-335975-m6lkrehi 4899 5 no no DT cord-335975-m6lkrehi 4899 6 analytical analytical JJ cord-335975-m6lkrehi 4899 7 confirmation confirmation NN cord-335975-m6lkrehi 4899 8 was be VBD cord-335975-m6lkrehi 4899 9 available available JJ cord-335975-m6lkrehi 4899 10 except except IN cord-335975-m6lkrehi 4899 11 for for IN cord-335975-m6lkrehi 4899 12 the the DT cord-335975-m6lkrehi 4899 13 patients patient NNS cord-335975-m6lkrehi 4899 14 admitted admit VBN cord-335975-m6lkrehi 4899 15 in in IN cord-335975-m6lkrehi 4899 16 the the DT cord-335975-m6lkrehi 4899 17 ICU ICU NNP cord-335975-m6lkrehi 4899 18 . . . cord-335975-m6lkrehi 4900 1 Results result NNS cord-335975-m6lkrehi 4900 2 Discussion Discussion NNP cord-335975-m6lkrehi 4901 1 During during IN cord-335975-m6lkrehi 4901 2 10 10 CD cord-335975-m6lkrehi 4901 3 months month NNS cord-335975-m6lkrehi 4901 4 , , , cord-335975-m6lkrehi 4901 5 818 818 CD cord-335975-m6lkrehi 4901 6 drug drug NN cord-335975-m6lkrehi 4901 7 users user NNS cord-335975-m6lkrehi 4901 8 [ [ -LRB- cord-335975-m6lkrehi 4901 9 F F NNP cord-335975-m6lkrehi 4901 10 M M NNP cord-335975-m6lkrehi 4901 11 sex sex NN cord-335975-m6lkrehi 4901 12 ratio ratio NN cord-335975-m6lkrehi 4901 13 0.13 0.13 CD cord-335975-m6lkrehi 4901 14 + + CC cord-335975-m6lkrehi 4901 15 median median NN cord-335975-m6lkrehi 4901 16 age age NN cord-335975-m6lkrehi 4901 17 37.8 37.8 CD cord-335975-m6lkrehi 4901 18 years year NNS cord-335975-m6lkrehi 4901 19 ( ( -LRB- cord-335975-m6lkrehi 4901 20 21 21 CD cord-335975-m6lkrehi 4901 21 - - SYM cord-335975-m6lkrehi 4901 22 69 69 CD cord-335975-m6lkrehi 4901 23 ) ) -RRB- cord-335975-m6lkrehi 4901 24 + + SYM cord-335975-m6lkrehi 4901 25 patients patient NNS cord-335975-m6lkrehi 4901 26 without without IN cord-335975-m6lkrehi 4901 27 resources resource NNS cord-335975-m6lkrehi 4901 28 ( ( -LRB- cord-335975-m6lkrehi 4901 29 40 40 CD cord-335975-m6lkrehi 4901 30 % % NN cord-335975-m6lkrehi 4901 31 ) ) -RRB- cord-335975-m6lkrehi 4901 32 , , , cord-335975-m6lkrehi 4901 33 without without IN cord-335975-m6lkrehi 4901 34 medical medical JJ cord-335975-m6lkrehi 4901 35 insurance insurance NN cord-335975-m6lkrehi 4901 36 ( ( -LRB- cord-335975-m6lkrehi 4901 37 27 27 CD cord-335975-m6lkrehi 4901 38 % % NN cord-335975-m6lkrehi 4901 39 ) ) -RRB- cord-335975-m6lkrehi 4901 40 , , , cord-335975-m6lkrehi 4901 41 unstable unstable JJ cord-335975-m6lkrehi 4901 42 housing housing NN cord-335975-m6lkrehi 4901 43 homelessness homelessness NN cord-335975-m6lkrehi 4901 44 ( ( -LRB- cord-335975-m6lkrehi 4901 45 52 52 CD cord-335975-m6lkrehi 4901 46 % % NN cord-335975-m6lkrehi 4901 47 ) ) -RRB- cord-335975-m6lkrehi 4901 48 ] ] -RRB- cord-335975-m6lkrehi 4901 49 visited visit VBD cord-335975-m6lkrehi 4901 50 the the DT cord-335975-m6lkrehi 4901 51 SIS SIS NNP cord-335975-m6lkrehi 4901 52 for for IN cord-335975-m6lkrehi 4901 53 drug drug NN cord-335975-m6lkrehi 4901 54 injection injection NN cord-335975-m6lkrehi 4901 55 or or CC cord-335975-m6lkrehi 4901 56 inhalation inhalation NN cord-335975-m6lkrehi 4901 57 , , , cord-335975-m6lkrehi 4901 58 representing represent VBG cord-335975-m6lkrehi 4901 59 50,060 50,060 CD cord-335975-m6lkrehi 4901 60 drug drug NN cord-335975-m6lkrehi 4901 61 use use NN cord-335975-m6lkrehi 4901 62 including include VBG cord-335975-m6lkrehi 4901 63 14,587 14,587 CD cord-335975-m6lkrehi 4901 64 inhalations inhalation NNS cord-335975-m6lkrehi 4901 65 and and CC cord-335975-m6lkrehi 4901 66 35,473 35,473 CD cord-335975-m6lkrehi 4901 67 injections injection NNS cord-335975-m6lkrehi 4901 68 by by IN cord-335975-m6lkrehi 4901 69 180 180 CD cord-335975-m6lkrehi 4901 70 drug drug NN cord-335975-m6lkrehi 4901 71 users user NNS cord-335975-m6lkrehi 4901 72 day day NN cord-335975-m6lkrehi 4901 73 . . . cord-335975-m6lkrehi 4902 1 Drug drug NN cord-335975-m6lkrehi 4902 2 users user NNS cord-335975-m6lkrehi 4902 3 had have VBD cord-335975-m6lkrehi 4902 4 no no DT cord-335975-m6lkrehi 4902 5 addictology addictology NN cord-335975-m6lkrehi 4902 6 ( ( -LRB- cord-335975-m6lkrehi 4902 7 48 48 CD cord-335975-m6lkrehi 4902 8 % % NN cord-335975-m6lkrehi 4902 9 ) ) -RRB- cord-335975-m6lkrehi 4902 10 or or CC cord-335975-m6lkrehi 4902 11 sociomedical sociomedical JJ cord-335975-m6lkrehi 4902 12 ( ( -LRB- cord-335975-m6lkrehi 4902 13 27 27 CD cord-335975-m6lkrehi 4902 14 % % NN cord-335975-m6lkrehi 4902 15 ) ) -RRB- cord-335975-m6lkrehi 4902 16 follow follow NN cord-335975-m6lkrehi 4902 17 - - HYPH cord-335975-m6lkrehi 4902 18 up up NN cord-335975-m6lkrehi 4902 19 . . . cord-335975-m6lkrehi 4903 1 They -PRON- PRP cord-335975-m6lkrehi 4903 2 were be VBD cord-335975-m6lkrehi 4903 3 infected infect VBN cord-335975-m6lkrehi 4903 4 by by IN cord-335975-m6lkrehi 4903 5 hepatitis hepatitis NN cord-335975-m6lkrehi 4903 6 virus virus NN cord-335975-m6lkrehi 4903 7 C C NNP cord-335975-m6lkrehi 4903 8 ( ( -LRB- cord-335975-m6lkrehi 4903 9 44 44 CD cord-335975-m6lkrehi 4903 10 % % NN cord-335975-m6lkrehi 4903 11 ) ) -RRB- cord-335975-m6lkrehi 4903 12 and and CC cord-335975-m6lkrehi 4903 13 or or CC cord-335975-m6lkrehi 4903 14 HIV HIV NNP cord-335975-m6lkrehi 4903 15 ( ( -LRB- cord-335975-m6lkrehi 4903 16 5 5 CD cord-335975-m6lkrehi 4903 17 % % NN cord-335975-m6lkrehi 4903 18 ) ) -RRB- cord-335975-m6lkrehi 4903 19 . . . cord-335975-m6lkrehi 4904 1 They -PRON- PRP cord-335975-m6lkrehi 4904 2 declared declare VBD cord-335975-m6lkrehi 4904 3 to to TO cord-335975-m6lkrehi 4904 4 continue continue VB cord-335975-m6lkrehi 4904 5 injecting inject VBG cord-335975-m6lkrehi 4904 6 in in IN cord-335975-m6lkrehi 4904 7 the the DT cord-335975-m6lkrehi 4904 8 public public JJ cord-335975-m6lkrehi 4904 9 space space NN cord-335975-m6lkrehi 4904 10 ( ( -LRB- cord-335975-m6lkrehi 4904 11 52 52 CD cord-335975-m6lkrehi 4904 12 % % NN cord-335975-m6lkrehi 4904 13 ) ) -RRB- cord-335975-m6lkrehi 4904 14 , , , cord-335975-m6lkrehi 4904 15 sharing share VBG cord-335975-m6lkrehi 4904 16 material material NN cord-335975-m6lkrehi 4904 17 ( ( -LRB- cord-335975-m6lkrehi 4904 18 13 13 CD cord-335975-m6lkrehi 4904 19 % % NN cord-335975-m6lkrehi 4904 20 ) ) -RRB- cord-335975-m6lkrehi 4904 21 , , , cord-335975-m6lkrehi 4904 22 and and CC cord-335975-m6lkrehi 4904 23 needles needle NNS cord-335975-m6lkrehi 4904 24 syringes syrinx NNS cord-335975-m6lkrehi 4904 25 ( ( -LRB- cord-335975-m6lkrehi 4904 26 47 47 CD cord-335975-m6lkrehi 4904 27 % % NN cord-335975-m6lkrehi 4904 28 ) ) -RRB- cord-335975-m6lkrehi 4904 29 . . . cord-335975-m6lkrehi 4905 1 The the DT cord-335975-m6lkrehi 4905 2 injected inject VBN cord-335975-m6lkrehi 4905 3 inhaled inhale VBN cord-335975-m6lkrehi 4905 4 drugs drug NNS cord-335975-m6lkrehi 4905 5 in in IN cord-335975-m6lkrehi 4905 6 the the DT cord-335975-m6lkrehi 4905 7 SIS SIS NNP cord-335975-m6lkrehi 4905 8 were be VBD cord-335975-m6lkrehi 4905 9 Skenan Skenan NNP cord-335975-m6lkrehi 4906 1 ® ® VB cord-335975-m6lkrehi 4906 2 ( ( -LRB- cord-335975-m6lkrehi 4906 3 morphine morphine NN cord-335975-m6lkrehi 4906 4 , , , cord-335975-m6lkrehi 4906 5 42.6 42.6 CD cord-335975-m6lkrehi 4906 6 % % NN cord-335975-m6lkrehi 4906 7 ) ) -RRB- cord-335975-m6lkrehi 4906 8 , , , cord-335975-m6lkrehi 4906 9 crack crack VB cord-335975-m6lkrehi 4906 10 ( ( -LRB- cord-335975-m6lkrehi 4906 11 43 43 CD cord-335975-m6lkrehi 4906 12 % % NN cord-335975-m6lkrehi 4906 13 including include VBG cord-335975-m6lkrehi 4906 14 1 1 CD cord-335975-m6lkrehi 4906 15 3 3 CD cord-335975-m6lkrehi 4906 16 injections injection NNS cord-335975-m6lkrehi 4906 17 ) ) -RRB- cord-335975-m6lkrehi 4906 18 , , , cord-335975-m6lkrehi 4906 19 methadone methadone FW cord-335975-m6lkrehi 4906 20 ( ( -LRB- cord-335975-m6lkrehi 4906 21 6.3 6.3 CD cord-335975-m6lkrehi 4906 22 % % NN cord-335975-m6lkrehi 4906 23 ) ) -RRB- cord-335975-m6lkrehi 4906 24 , , , cord-335975-m6lkrehi 4906 25 buprenorphine buprenorphine NN cord-335975-m6lkrehi 4906 26 ( ( -LRB- cord-335975-m6lkrehi 4906 27 6.1 6.1 CD cord-335975-m6lkrehi 4906 28 % % NN cord-335975-m6lkrehi 4906 29 ) ) -RRB- cord-335975-m6lkrehi 4906 30 , , , cord-335975-m6lkrehi 4906 31 heroine heroine NN cord-335975-m6lkrehi 4906 32 ( ( -LRB- cord-335975-m6lkrehi 4906 33 1.2 1.2 CD cord-335975-m6lkrehi 4906 34 % % NN cord-335975-m6lkrehi 4906 35 ) ) -RRB- cord-335975-m6lkrehi 4906 36 , , , cord-335975-m6lkrehi 4906 37 and and CC cord-335975-m6lkrehi 4906 38 cocaine cocaine NN cord-335975-m6lkrehi 4906 39 ( ( -LRB- cord-335975-m6lkrehi 4906 40 0.89 0.89 CD cord-335975-m6lkrehi 4906 41 % % NN cord-335975-m6lkrehi 4906 42 ) ) -RRB- cord-335975-m6lkrehi 4906 43 . . . cord-335975-m6lkrehi 4907 1 These these DT cord-335975-m6lkrehi 4907 2 drugs drug NNS cord-335975-m6lkrehi 4907 3 were be VBD cord-335975-m6lkrehi 4907 4 self self NN cord-335975-m6lkrehi 4907 5 - - HYPH cord-335975-m6lkrehi 4907 6 administered administer VBN cord-335975-m6lkrehi 4907 7 by by IN cord-335975-m6lkrehi 4907 8 polydrug polydrug NN cord-335975-m6lkrehi 4907 9 users user NNS cord-335975-m6lkrehi 4907 10 declaring declare VBG cord-335975-m6lkrehi 4907 11 concomitantly concomitantly RB cord-335975-m6lkrehi 4907 12 consuming consume VBG cord-335975-m6lkrehi 4907 13 crack crack NN cord-335975-m6lkrehi 4907 14 ( ( -LRB- cord-335975-m6lkrehi 4907 15 72.0 72.0 CD cord-335975-m6lkrehi 4907 16 % % NN cord-335975-m6lkrehi 4907 17 ) ) -RRB- cord-335975-m6lkrehi 4907 18 , , , cord-335975-m6lkrehi 4907 19 illicit illicit JJ cord-335975-m6lkrehi 4907 20 morphine morphine NN cord-335975-m6lkrehi 4907 21 ( ( -LRB- cord-335975-m6lkrehi 4907 22 68.5 68.5 CD cord-335975-m6lkrehi 4907 23 % % NN cord-335975-m6lkrehi 4907 24 ) ) -RRB- cord-335975-m6lkrehi 4907 25 , , , cord-335975-m6lkrehi 4907 26 cocaine cocaine NN cord-335975-m6lkrehi 4907 27 ( ( -LRB- cord-335975-m6lkrehi 4907 28 34.8 34.8 CD cord-335975-m6lkrehi 4907 29 % % NN cord-335975-m6lkrehi 4907 30 ) ) -RRB- cord-335975-m6lkrehi 4907 31 , , , cord-335975-m6lkrehi 4907 32 ethanol ethanol NN cord-335975-m6lkrehi 4907 33 ( ( -LRB- cord-335975-m6lkrehi 4907 34 33.7 33.7 CD cord-335975-m6lkrehi 4907 35 % % NN cord-335975-m6lkrehi 4907 36 ) ) -RRB- cord-335975-m6lkrehi 4907 37 , , , cord-335975-m6lkrehi 4907 38 cannabis cannabis NN cord-335975-m6lkrehi 4907 39 ( ( -LRB- cord-335975-m6lkrehi 4907 40 33.4 33.4 CD cord-335975-m6lkrehi 4907 41 % % NN cord-335975-m6lkrehi 4907 42 ) ) -RRB- cord-335975-m6lkrehi 4907 43 , , , cord-335975-m6lkrehi 4907 44 heroin heroin NN cord-335975-m6lkrehi 4907 45 ( ( -LRB- cord-335975-m6lkrehi 4907 46 29.9 29.9 CD cord-335975-m6lkrehi 4907 47 % % NN cord-335975-m6lkrehi 4907 48 ) ) -RRB- cord-335975-m6lkrehi 4907 49 , , , cord-335975-m6lkrehi 4907 50 illicit illicit JJ cord-335975-m6lkrehi 4907 51 methadone methadone NN cord-335975-m6lkrehi 4907 52 ( ( -LRB- cord-335975-m6lkrehi 4907 53 20.4 20.4 CD cord-335975-m6lkrehi 4907 54 % % NN cord-335975-m6lkrehi 4907 55 ) ) -RRB- cord-335975-m6lkrehi 4907 56 , , , cord-335975-m6lkrehi 4907 57 benzodiazepines benzodiazepine NNS cord-335975-m6lkrehi 4907 58 ( ( -LRB- cord-335975-m6lkrehi 4907 59 13.6 13.6 CD cord-335975-m6lkrehi 4907 60 % % NN cord-335975-m6lkrehi 4907 61 ) ) -RRB- cord-335975-m6lkrehi 4907 62 and and CC cord-335975-m6lkrehi 4907 63 illicit illicit JJ cord-335975-m6lkrehi 4907 64 buprenorphine buprenorphine NN cord-335975-m6lkrehi 4907 65 ( ( -LRB- cord-335975-m6lkrehi 4907 66 9.5 9.5 CD cord-335975-m6lkrehi 4907 67 % % NN cord-335975-m6lkrehi 4907 68 ) ) -RRB- cord-335975-m6lkrehi 4907 69 . . . cord-335975-m6lkrehi 4908 1 Forty forty CD cord-335975-m6lkrehi 4908 2 - - HYPH cord-335975-m6lkrehi 4908 3 five five CD cord-335975-m6lkrehi 4908 4 patients patient NNS cord-335975-m6lkrehi 4908 5 required require VBD cord-335975-m6lkrehi 4908 6 a a DT cord-335975-m6lkrehi 4908 7 paramedical paramedical JJ cord-335975-m6lkrehi 4908 8 intervention intervention NN cord-335975-m6lkrehi 4908 9 in in IN cord-335975-m6lkrehi 4908 10 the the DT cord-335975-m6lkrehi 4908 11 SIS SIS NNP cord-335975-m6lkrehi 4908 12 resulting result VBG cord-335975-m6lkrehi 4908 13 in in IN cord-335975-m6lkrehi 4908 14 17 17 CD cord-335975-m6lkrehi 4908 15 calls call NNS cord-335975-m6lkrehi 4908 16 to to IN cord-335975-m6lkrehi 4908 17 the the DT cord-335975-m6lkrehi 4908 18 emergency emergency NN cord-335975-m6lkrehi 4908 19 department department NN cord-335975-m6lkrehi 4908 20 and and CC cord-335975-m6lkrehi 4908 21 15 15 CD cord-335975-m6lkrehi 4908 22 hospital hospital NN cord-335975-m6lkrehi 4908 23 admissions admission NNS cord-335975-m6lkrehi 4908 24 including include VBG cord-335975-m6lkrehi 4908 25 2 2 CD cord-335975-m6lkrehi 4908 26 transfers transfer NNS cord-335975-m6lkrehi 4908 27 to to IN cord-335975-m6lkrehi 4908 28 the the DT cord-335975-m6lkrehi 4908 29 ICU ICU NNP cord-335975-m6lkrehi 4908 30 in in IN cord-335975-m6lkrehi 4908 31 relation relation NN cord-335975-m6lkrehi 4908 32 to to IN cord-335975-m6lkrehi 4908 33 opioid opioid JJ cord-335975-m6lkrehi 4908 34 overdose overdose NN cord-335975-m6lkrehi 4908 35 . . . cord-335975-m6lkrehi 4909 1 No no DT cord-335975-m6lkrehi 4909 2 cardiac cardiac JJ cord-335975-m6lkrehi 4909 3 arrest arrest NN cord-335975-m6lkrehi 4909 4 and and CC cord-335975-m6lkrehi 4909 5 no no DT cord-335975-m6lkrehi 4909 6 death death NN cord-335975-m6lkrehi 4909 7 occurred occur VBD cord-335975-m6lkrehi 4909 8 . . . cord-335975-m6lkrehi 4910 1 Conclusion conclusion NN cord-335975-m6lkrehi 4910 2 : : : cord-335975-m6lkrehi 4910 3 SIS SIS NNP cord-335975-m6lkrehi 4910 4 visit visit NN cord-335975-m6lkrehi 4910 5 for for IN cord-335975-m6lkrehi 4910 6 recreational recreational JJ cord-335975-m6lkrehi 4910 7 drug drug NN cord-335975-m6lkrehi 4910 8 self self NN cord-335975-m6lkrehi 4910 9 - - HYPH cord-335975-m6lkrehi 4910 10 administration administration NN cord-335975-m6lkrehi 4910 11 rapidly rapidly RB cord-335975-m6lkrehi 4910 12 becomes become VBZ cord-335975-m6lkrehi 4910 13 popular popular JJ cord-335975-m6lkrehi 4910 14 among among IN cord-335975-m6lkrehi 4910 15 drug drug NN cord-335975-m6lkrehi 4910 16 users user NNS cord-335975-m6lkrehi 4910 17 . . . cord-335975-m6lkrehi 4911 1 Illicit illicit JJ cord-335975-m6lkrehi 4911 2 morphine morphine NN cord-335975-m6lkrehi 4911 3 ( ( -LRB- cord-335975-m6lkrehi 4911 4 Skenan Skenan NNP cord-335975-m6lkrehi 4911 5 ® ® POS cord-335975-m6lkrehi 4911 6 ) ) -RRB- cord-335975-m6lkrehi 4911 7 Glycemia Glycemia NNP cord-335975-m6lkrehi 4911 8 ( ( -LRB- cord-335975-m6lkrehi 4911 9 mmol mmol NNP cord-335975-m6lkrehi 4911 10 / / SYM cord-335975-m6lkrehi 4911 11 l l NN cord-335975-m6lkrehi 4911 12 ) ) -RRB- cord-335975-m6lkrehi 4912 1 6.2 6.2 CD cord-335975-m6lkrehi 4912 2 ( ( -LRB- cord-335975-m6lkrehi 4912 3 5 5 CD cord-335975-m6lkrehi 4912 4 - - SYM cord-335975-m6lkrehi 4912 5 7 7 CD cord-335975-m6lkrehi 4912 6 ) ) -RRB- cord-335975-m6lkrehi 4912 7 6.5 6.5 CD cord-335975-m6lkrehi 4913 1 ( ( -LRB- cord-335975-m6lkrehi 4913 2 5 5 CD cord-335975-m6lkrehi 4913 3 - - SYM cord-335975-m6lkrehi 4913 4 8)Ketones 8)ketones CD cord-335975-m6lkrehi 4913 5 in in IN cord-335975-m6lkrehi 4913 6 the the DT cord-335975-m6lkrehi 4913 7 effluent effluent NN cord-335975-m6lkrehi 4913 8 liquid liquid NN cord-335975-m6lkrehi 4913 9 ( ( -LRB- cord-335975-m6lkrehi 4913 10 g g NN cord-335975-m6lkrehi 4913 11 / / SYM cord-335975-m6lkrehi 4913 12 l l NN cord-335975-m6lkrehi 4913 13 ) ) -RRB- cord-335975-m6lkrehi 4913 14 0.15 0.15 CD cord-335975-m6lkrehi 4913 15 ( ( -LRB- cord-335975-m6lkrehi 4913 16 0.025 0.025 CD cord-335975-m6lkrehi 4913 17 - - SYM cord-335975-m6lkrehi 4913 18 0.8 0.8 CD cord-335975-m6lkrehi 4913 19 ) ) -RRB- cord-335975-m6lkrehi 4913 20 0 0 NFP cord-335975-m6lkrehi 4914 1 ( ( -LRB- cord-335975-m6lkrehi 4914 2 0 0 CD cord-335975-m6lkrehi 4914 3 - - SYM cord-335975-m6lkrehi 4914 4 0 0 CD cord-335975-m6lkrehi 4914 5 ) ) -RRB- cord-335975-m6lkrehi 4914 6 Patients patient NNS cord-335975-m6lkrehi 4914 7 and and CC cord-335975-m6lkrehi 4914 8 methods method NNS cord-335975-m6lkrehi 4914 9 : : : cord-335975-m6lkrehi 4914 10 Physiological physiological JJ cord-335975-m6lkrehi 4914 11 tracings tracing NNS cord-335975-m6lkrehi 4914 12 were be VBD cord-335975-m6lkrehi 4914 13 recorded record VBN cord-335975-m6lkrehi 4914 14 from from IN cord-335975-m6lkrehi 4914 15 the the DT cord-335975-m6lkrehi 4914 16 standard standard JJ cord-335975-m6lkrehi 4914 17 monitoring monitoring NN cord-335975-m6lkrehi 4914 18 system system NN cord-335975-m6lkrehi 4914 19 ( ( -LRB- cord-335975-m6lkrehi 4914 20 Intelliview Intelliview NNP cord-335975-m6lkrehi 4914 21 MP70 MP70 NNP cord-335975-m6lkrehi 4914 22 Philips Philips NNP cord-335975-m6lkrehi 4914 23 ) ) -RRB- cord-335975-m6lkrehi 4914 24 , , , cord-335975-m6lkrehi 4914 25 using use VBG cord-335975-m6lkrehi 4914 26 a a DT cord-335975-m6lkrehi 4914 27 dedicated dedicated JJ cord-335975-m6lkrehi 4914 28 network network NN cord-335975-m6lkrehi 4914 29 and and CC cord-335975-m6lkrehi 4914 30 extraction extraction NN cord-335975-m6lkrehi 4914 31 software software NN cord-335975-m6lkrehi 4914 32 ( ( -LRB- cord-335975-m6lkrehi 4914 33 Synapse Synapse NNP cord-335975-m6lkrehi 4914 34 v1 v1 NNS cord-335975-m6lkrehi 4914 35 , , , cord-335975-m6lkrehi 4914 36 LTSI LTSI NNP cord-335975-m6lkrehi 4914 37 INSERM INSERM NNP cord-335975-m6lkrehi 4914 38 U1099 U1099 NNP cord-335975-m6lkrehi 4914 39 ) ) -RRB- cord-335975-m6lkrehi 4914 40 that that WDT cord-335975-m6lkrehi 4914 41 enables enable VBZ cord-335975-m6lkrehi 4914 42 photoplethysmographic photoplethysmographic JJ cord-335975-m6lkrehi 4914 43 recordings recording NNS cord-335975-m6lkrehi 4914 44 from from IN cord-335975-m6lkrehi 4914 45 oximetry oximetry NN cord-335975-m6lkrehi 4914 46 monitoring monitoring NN cord-335975-m6lkrehi 4914 47 at at IN cord-335975-m6lkrehi 4914 48 a a DT cord-335975-m6lkrehi 4914 49 native native JJ cord-335975-m6lkrehi 4914 50 resolution resolution NN cord-335975-m6lkrehi 4914 51 of of IN cord-335975-m6lkrehi 4914 52 125 125 CD cord-335975-m6lkrehi 4914 53 Hz Hz NNP cord-335975-m6lkrehi 4914 54 . . . cord-335975-m6lkrehi 4915 1 Raw raw JJ cord-335975-m6lkrehi 4915 2 data datum NNS cord-335975-m6lkrehi 4915 3 were be VBD cord-335975-m6lkrehi 4915 4 subsequently subsequently RB cord-335975-m6lkrehi 4915 5 stored store VBN cord-335975-m6lkrehi 4915 6 on on IN cord-335975-m6lkrehi 4915 7 a a DT cord-335975-m6lkrehi 4915 8 dedicated dedicated JJ cord-335975-m6lkrehi 4915 9 local local JJ cord-335975-m6lkrehi 4915 10 server server NN cord-335975-m6lkrehi 4915 11 , , , cord-335975-m6lkrehi 4915 12 before before IN cord-335975-m6lkrehi 4915 13 anonymization anonymization NN cord-335975-m6lkrehi 4915 14 and and CC cord-335975-m6lkrehi 4915 15 analysis analysis NN cord-335975-m6lkrehi 4915 16 . . . cord-335975-m6lkrehi 4916 1 All all DT cord-335975-m6lkrehi 4916 2 consecutive consecutive JJ cord-335975-m6lkrehi 4916 3 patients patient NNS cord-335975-m6lkrehi 4916 4 were be VBD cord-335975-m6lkrehi 4916 5 recorded record VBN cord-335975-m6lkrehi 4916 6 for for IN cord-335975-m6lkrehi 4916 7 a a DT cord-335975-m6lkrehi 4916 8 2-hours 2-hours CD cord-335975-m6lkrehi 4916 9 period period NN cord-335975-m6lkrehi 4916 10 during during IN cord-335975-m6lkrehi 4916 11 the the DT cord-335975-m6lkrehi 4916 12 24-hours 24-hours CD cord-335975-m6lkrehi 4916 13 following follow VBG cord-335975-m6lkrehi 4916 14 ICU ICU NNP cord-335975-m6lkrehi 4916 15 admission admission NN cord-335975-m6lkrehi 4916 16 . . . cord-335975-m6lkrehi 4917 1 All all DT cord-335975-m6lkrehi 4917 2 measurements measurement NNS cord-335975-m6lkrehi 4917 3 were be VBD cord-335975-m6lkrehi 4917 4 recorded record VBN cord-335975-m6lkrehi 4917 5 with with IN cord-335975-m6lkrehi 4917 6 the the DT cord-335975-m6lkrehi 4917 7 patient patient NN cord-335975-m6lkrehi 4917 8 laying lay VBG cord-335975-m6lkrehi 4917 9 supine supine JJ cord-335975-m6lkrehi 4917 10 , , , cord-335975-m6lkrehi 4917 11 with with IN cord-335975-m6lkrehi 4917 12 a a DT cord-335975-m6lkrehi 4917 13 30 30 CD cord-335975-m6lkrehi 4917 14 ° ° NN cord-335975-m6lkrehi 4917 15 bed bed NN cord-335975-m6lkrehi 4917 16 head head NN cord-335975-m6lkrehi 4917 17 angulation angulation NN cord-335975-m6lkrehi 4917 18 . . . cord-335975-m6lkrehi 4918 1 Physiological physiological JJ cord-335975-m6lkrehi 4918 2 recordings recording NNS cord-335975-m6lkrehi 4918 3 were be VBD cord-335975-m6lkrehi 4918 4 associated associate VBN cord-335975-m6lkrehi 4918 5 with with IN cord-335975-m6lkrehi 4918 6 metadata metadata NN cord-335975-m6lkrehi 4918 7 collection collection NN cord-335975-m6lkrehi 4918 8 by by IN cord-335975-m6lkrehi 4918 9 a a DT cord-335975-m6lkrehi 4918 10 dedicated dedicated JJ cord-335975-m6lkrehi 4918 11 research research NN cord-335975-m6lkrehi 4918 12 assistant assistant NN cord-335975-m6lkrehi 4918 13 . . . cord-335975-m6lkrehi 4919 1 HRV HRV NNP cord-335975-m6lkrehi 4919 2 parameters parameter NNS cord-335975-m6lkrehi 4919 3 defined define VBN cord-335975-m6lkrehi 4919 4 in in IN cord-335975-m6lkrehi 4919 5 a a DT cord-335975-m6lkrehi 4919 6 previous previous JJ cord-335975-m6lkrehi 4919 7 study study NN cord-335975-m6lkrehi 4919 8 were be VBD cord-335975-m6lkrehi 4919 9 derived derive VBN cord-335975-m6lkrehi 4919 10 using use VBG cord-335975-m6lkrehi 4919 11 Kubios Kubios NNP cord-335975-m6lkrehi 4919 12 HRV HRV NNP cord-335975-m6lkrehi 4919 13 premium premium NN cord-335975-m6lkrehi 4919 14 ( ( -LRB- cord-335975-m6lkrehi 4919 15 Introduction introduction NN cord-335975-m6lkrehi 4919 16 : : : cord-335975-m6lkrehi 4919 17 Preventing prevent VBG cord-335975-m6lkrehi 4919 18 post post JJ cord-335975-m6lkrehi 4919 19 liver liver NN cord-335975-m6lkrehi 4919 20 transplantation transplantation NN cord-335975-m6lkrehi 4919 21 ( ( -LRB- cord-335975-m6lkrehi 4919 22 LT LT NNP cord-335975-m6lkrehi 4919 23 ) ) -RRB- cord-335975-m6lkrehi 4919 24 hepatic hepatic JJ cord-335975-m6lkrehi 4919 25 artery artery NN cord-335975-m6lkrehi 4919 26 and and CC cord-335975-m6lkrehi 4919 27 portal portal JJ cord-335975-m6lkrehi 4919 28 vein vein NN cord-335975-m6lkrehi 4919 29 thrombosis thrombosis NN cord-335975-m6lkrehi 4919 30 is be VBZ cord-335975-m6lkrehi 4919 31 challenging challenging JJ cord-335975-m6lkrehi 4919 32 and and CC cord-335975-m6lkrehi 4919 33 includes include VBZ cord-335975-m6lkrehi 4919 34 enoxaparin enoxaparin NNP cord-335975-m6lkrehi 4919 35 administration administration NN cord-335975-m6lkrehi 4919 36 . . . cord-335975-m6lkrehi 4920 1 Enoxaparin Enoxaparin NNP cord-335975-m6lkrehi 4920 2 pharmacokinetics pharmacokinetic NNS cord-335975-m6lkrehi 4920 3 ( ( -LRB- cord-335975-m6lkrehi 4920 4 PK PK NNP cord-335975-m6lkrehi 4920 5 ) ) -RRB- cord-335975-m6lkrehi 4920 6 has have VBZ cord-335975-m6lkrehi 4920 7 not not RB cord-335975-m6lkrehi 4920 8 been be VBN cord-335975-m6lkrehi 4920 9 investigated investigate VBN cord-335975-m6lkrehi 4920 10 in in IN cord-335975-m6lkrehi 4920 11 children child NNS cord-335975-m6lkrehi 4920 12 following follow VBG cord-335975-m6lkrehi 4920 13 LT LT NNP cord-335975-m6lkrehi 4920 14 . . . cord-335975-m6lkrehi 4921 1 Between between IN cord-335975-m6lkrehi 4921 2 - - HYPH cord-335975-m6lkrehi 4921 3 subject subject NN cord-335975-m6lkrehi 4921 4 variability variability NN cord-335975-m6lkrehi 4921 5 and and CC cord-335975-m6lkrehi 4921 6 critical critical JJ cord-335975-m6lkrehi 4921 7 illness illness NN cord-335975-m6lkrehi 4921 8 may may MD cord-335975-m6lkrehi 4921 9 alter alter VB cord-335975-m6lkrehi 4921 10 PK PK NNP cord-335975-m6lkrehi 4921 11 , , , cord-335975-m6lkrehi 4921 12 leading lead VBG cord-335975-m6lkrehi 4921 13 to to IN cord-335975-m6lkrehi 4921 14 the the DT cord-335975-m6lkrehi 4921 15 risk risk NN cord-335975-m6lkrehi 4921 16 of of IN cord-335975-m6lkrehi 4921 17 subtherapeutic subtherapeutic JJ cord-335975-m6lkrehi 4921 18 exposure exposure NN cord-335975-m6lkrehi 4921 19 . . . cord-335975-m6lkrehi 4922 1 Patients patient NNS cord-335975-m6lkrehi 4922 2 and and CC cord-335975-m6lkrehi 4922 3 methods method NNS cord-335975-m6lkrehi 4922 4 : : : cord-335975-m6lkrehi 4922 5 Clinical clinical JJ cord-335975-m6lkrehi 4922 6 , , , cord-335975-m6lkrehi 4922 7 biological biological JJ cord-335975-m6lkrehi 4922 8 and and CC cord-335975-m6lkrehi 4922 9 kinetic kinetic JJ cord-335975-m6lkrehi 4922 10 data datum NNS cord-335975-m6lkrehi 4922 11 were be VBD cord-335975-m6lkrehi 4922 12 retrospectively retrospectively RB cord-335975-m6lkrehi 4922 13 collected collect VBN cord-335975-m6lkrehi 4922 14 in in IN cord-335975-m6lkrehi 4922 15 a a DT cord-335975-m6lkrehi 4922 16 single single JJ cord-335975-m6lkrehi 4922 17 Pediatric Pediatric NNP cord-335975-m6lkrehi 4922 18 Intensive Intensive NNP cord-335975-m6lkrehi 4922 19 Care Care NNP cord-335975-m6lkrehi 4922 20 Unit Unit NNP cord-335975-m6lkrehi 4922 21 center center NN cord-335975-m6lkrehi 4922 22 from from IN cord-335975-m6lkrehi 4922 23 January January NNP cord-335975-m6lkrehi 4922 24 2013 2013 CD cord-335975-m6lkrehi 4922 25 to to IN cord-335975-m6lkrehi 4922 26 July July NNP cord-335975-m6lkrehi 4922 27 2015 2015 CD cord-335975-m6lkrehi 4922 28 . . . cord-335975-m6lkrehi 4923 1 We -PRON- PRP cord-335975-m6lkrehi 4923 2 described describe VBD cord-335975-m6lkrehi 4923 3 an an DT cord-335975-m6lkrehi 4923 4 enoxaparin enoxaparin NN cord-335975-m6lkrehi 4923 5 PK PK NNP cord-335975-m6lkrehi 4923 6 model model NN cord-335975-m6lkrehi 4923 7 in in IN cord-335975-m6lkrehi 4923 8 22 22 CD cord-335975-m6lkrehi 4923 9 children child NNS cord-335975-m6lkrehi 4923 10 the the DT cord-335975-m6lkrehi 4923 11 first first JJ cord-335975-m6lkrehi 4923 12 week week NN cord-335975-m6lkrehi 4923 13 following follow VBG cord-335975-m6lkrehi 4923 14 the the DT cord-335975-m6lkrehi 4923 15 LT LT NNP cord-335975-m6lkrehi 4923 16 . . . cord-335975-m6lkrehi 4924 1 Anti Anti NNP cord-335975-m6lkrehi 4924 2 - - JJ cord-335975-m6lkrehi 4924 3 Xa Xa NNP cord-335975-m6lkrehi 4924 4 activity activity NN cord-335975-m6lkrehi 4924 5 timecourses timecourse NNS cord-335975-m6lkrehi 4924 6 were be VBD cord-335975-m6lkrehi 4924 7 analyzed analyze VBN cord-335975-m6lkrehi 4924 8 using use VBG cord-335975-m6lkrehi 4924 9 a a DT cord-335975-m6lkrehi 4924 10 non non JJ cord-335975-m6lkrehi 4924 11 linear linear JJ cord-335975-m6lkrehi 4924 12 mixed mixed JJ cord-335975-m6lkrehi 4924 13 effects effect NNS cord-335975-m6lkrehi 4924 14 approach approach NN cord-335975-m6lkrehi 4924 15 with with IN cord-335975-m6lkrehi 4924 16 Monolix Monolix NNP cord-335975-m6lkrehi 4924 17 version version NN cord-335975-m6lkrehi 4924 18 2016R. 2016r. CD cord-335975-m6lkrehi 4924 19 Results result NNS cord-335975-m6lkrehi 4924 20 : : : cord-335975-m6lkrehi 4924 21 Anti Anti NNP cord-335975-m6lkrehi 4924 22 - - JJ cord-335975-m6lkrehi 4924 23 Xa Xa NNP cord-335975-m6lkrehi 4924 24 activity activity NN cord-335975-m6lkrehi 4924 25 time time NN cord-335975-m6lkrehi 4924 26 - - HYPH cord-335975-m6lkrehi 4924 27 courses course NNS cord-335975-m6lkrehi 4924 28 were be VBD cord-335975-m6lkrehi 4924 29 well well RB cord-335975-m6lkrehi 4924 30 described describe VBN cord-335975-m6lkrehi 4924 31 by by IN cord-335975-m6lkrehi 4924 32 a a DT cord-335975-m6lkrehi 4924 33 one one CD cord-335975-m6lkrehi 4924 34 - - HYPH cord-335975-m6lkrehi 4924 35 compartment compartment NN cord-335975-m6lkrehi 4924 36 open open JJ cord-335975-m6lkrehi 4924 37 model model NN cord-335975-m6lkrehi 4924 38 with with IN cord-335975-m6lkrehi 4924 39 first first JJ cord-335975-m6lkrehi 4924 40 order order NN cord-335975-m6lkrehi 4924 41 absorption absorption NN cord-335975-m6lkrehi 4924 42 and and CC cord-335975-m6lkrehi 4924 43 elimination elimination NN cord-335975-m6lkrehi 4924 44 . . . cord-335975-m6lkrehi 4925 1 Body body NN cord-335975-m6lkrehi 4925 2 weight weight NN cord-335975-m6lkrehi 4925 3 prior prior IN cord-335975-m6lkrehi 4925 4 the the DT cord-335975-m6lkrehi 4925 5 surgery surgery NN cord-335975-m6lkrehi 4925 6 ( ( -LRB- cord-335975-m6lkrehi 4925 7 BWPREOP BWPREOP NNP cord-335975-m6lkrehi 4925 8 ) ) -RRB- cord-335975-m6lkrehi 4925 9 and and CC cord-335975-m6lkrehi 4926 1 the the DT cord-335975-m6lkrehi 4926 2 related related JJ cord-335975-m6lkrehi 4926 3 postoperative postoperative JJ cord-335975-m6lkrehi 4926 4 variation variation NN cord-335975-m6lkrehi 4926 5 ( ( -LRB- cord-335975-m6lkrehi 4926 6 BW(t BW(t NNP cord-335975-m6lkrehi 4926 7 ) ) -RRB- cord-335975-m6lkrehi 4926 8 ) ) -RRB- cord-335975-m6lkrehi 4926 9 were be VBD cord-335975-m6lkrehi 4926 10 the the DT cord-335975-m6lkrehi 4926 11 main main JJ cord-335975-m6lkrehi 4926 12 covariates covariate NNS cord-335975-m6lkrehi 4926 13 explaining explain VBG cord-335975-m6lkrehi 4926 14 CL CL NNP cord-335975-m6lkrehi 4926 15 and and CC cord-335975-m6lkrehi 4926 16 V v NN cord-335975-m6lkrehi 4926 17 between between IN cord-335975-m6lkrehi 4926 18 subject subject JJ cord-335975-m6lkrehi 4926 19 variabilities variability NNS cord-335975-m6lkrehi 4926 20 . . . cord-335975-m6lkrehi 4927 1 Parameter parameter NN cord-335975-m6lkrehi 4927 2 estimates estimate NNS cord-335975-m6lkrehi 4927 3 were be VBD cord-335975-m6lkrehi 4927 4 CLi CLi NNS cord-335975-m6lkrehi 4927 5 = = NFP cord-335975-m6lkrehi 4928 1 CLTYP*(BWPREOP CLTYP*(BWPREOP NNP cord-335975-m6lkrehi 4929 1 70)3 70)3 CD cord-335975-m6lkrehi 4929 2 4 4 CD cord-335975-m6lkrehi 4930 1 + + CC cord-335975-m6lkrehi 4931 1 Vi Vi NNP cord-335975-m6lkrehi 4931 2 = = NFP cord-335975-m6lkrehi 4932 1 VTYP*(BW(t VTYP*(BW(t NNP cord-335975-m6lkrehi 4932 2 ) ) -RRB- cord-335975-m6lkrehi 4933 1 70)1 70)1 CD cord-335975-m6lkrehi 4933 2 + + CD cord-335975-m6lkrehi 4934 1 where where WRB cord-335975-m6lkrehi 4934 2 typical typical JJ cord-335975-m6lkrehi 4934 3 clearance clearance NN cord-335975-m6lkrehi 4934 4 ( ( -LRB- cord-335975-m6lkrehi 4934 5 CLTYP CLTYP NNP cord-335975-m6lkrehi 4934 6 ) ) -RRB- cord-335975-m6lkrehi 4934 7 and and CC cord-335975-m6lkrehi 4934 8 typical typical JJ cord-335975-m6lkrehi 4934 9 volume volume NN cord-335975-m6lkrehi 4934 10 of of IN cord-335975-m6lkrehi 4934 11 distribution distribution NN cord-335975-m6lkrehi 4934 12 ( ( -LRB- cord-335975-m6lkrehi 4934 13 VTYP VTYP NNP cord-335975-m6lkrehi 4934 14 ) ) -RRB- cord-335975-m6lkrehi 4934 15 were be VBD cord-335975-m6lkrehi 4934 16 1.26 1.26 CD cord-335975-m6lkrehi 4934 17 L l NN cord-335975-m6lkrehi 4934 18 h h NN cord-335975-m6lkrehi 4934 19 −1 −1 NNP cord-335975-m6lkrehi 4934 20 and and CC cord-335975-m6lkrehi 4934 21 16.9 16.9 CD cord-335975-m6lkrehi 4934 22 L l NN cord-335975-m6lkrehi 4934 23 , , , cord-335975-m6lkrehi 4934 24 respectively respectively RB cord-335975-m6lkrehi 4934 25 . . . cord-335975-m6lkrehi 4935 1 Standard standard JJ cord-335975-m6lkrehi 4935 2 dosing dose VBG cord-335975-m6lkrehi 4935 3 regimens regimen NNS cord-335975-m6lkrehi 4935 4 of of IN cord-335975-m6lkrehi 4935 5 50 50 CD cord-335975-m6lkrehi 4935 6 IU IU NNP cord-335975-m6lkrehi 4935 7 kg kg NNP cord-335975-m6lkrehi 4935 8 12 12 CD cord-335975-m6lkrehi 4935 9 h h NN cord-335975-m6lkrehi 4935 10 were be VBD cord-335975-m6lkrehi 4935 11 insufficient insufficient JJ cord-335975-m6lkrehi 4935 12 to to TO cord-335975-m6lkrehi 4935 13 reach reach VB cord-335975-m6lkrehi 4935 14 the the DT cord-335975-m6lkrehi 4935 15 target target NN cord-335975-m6lkrehi 4935 16 range range NN cord-335975-m6lkrehi 4935 17 of of IN cord-335975-m6lkrehi 4935 18 anti anti JJ cord-335975-m6lkrehi 4935 19 - - JJ cord-335975-m6lkrehi 4935 20 Xa xa JJ cord-335975-m6lkrehi 4935 21 activity activity NN cord-335975-m6lkrehi 4935 22 of of IN cord-335975-m6lkrehi 4936 1 0.2 0.2 CD cord-335975-m6lkrehi 4936 2 to to IN cord-335975-m6lkrehi 4936 3 0.4 0.4 CD cord-335975-m6lkrehi 4936 4 IU IU NNP cord-335975-m6lkrehi 4936 5 mL. mL. NNS cord-335975-m6lkrehi 4936 6 Specifically specifically RB cord-335975-m6lkrehi 4936 7 , , , cord-335975-m6lkrehi 4936 8 7 7 CD cord-335975-m6lkrehi 4936 9 children child NNS cord-335975-m6lkrehi 4936 10 ( ( -LRB- cord-335975-m6lkrehi 4936 11 32 32 CD cord-335975-m6lkrehi 4936 12 % % NN cord-335975-m6lkrehi 4936 13 ) ) -RRB- cord-335975-m6lkrehi 4936 14 did do VBD cord-335975-m6lkrehi 4936 15 never never RB cord-335975-m6lkrehi 4936 16 attain attain VB cord-335975-m6lkrehi 4936 17 the the DT cord-335975-m6lkrehi 4936 18 target target NN cord-335975-m6lkrehi 4936 19 range range NN cord-335975-m6lkrehi 4936 20 during during IN cord-335975-m6lkrehi 4936 21 the the DT cord-335975-m6lkrehi 4936 22 whole whole JJ cord-335975-m6lkrehi 4936 23 period period NN cord-335975-m6lkrehi 4936 24 of of IN cord-335975-m6lkrehi 4936 25 treatment treatment NN cord-335975-m6lkrehi 4936 26 and and CC cord-335975-m6lkrehi 4936 27 all all DT cord-335975-m6lkrehi 4936 28 children child NNS cord-335975-m6lkrehi 4936 29 were be VBD cord-335975-m6lkrehi 4936 30 at at IN cord-335975-m6lkrehi 4936 31 least least JJS cord-335975-m6lkrehi 4936 32 once once RB cord-335975-m6lkrehi 4936 33 under under IN cord-335975-m6lkrehi 4936 34 dosed dose VBN cord-335975-m6lkrehi 4936 35 . . . cord-335975-m6lkrehi 4937 1 According accord VBG cord-335975-m6lkrehi 4937 2 to to IN cord-335975-m6lkrehi 4937 3 the the DT cord-335975-m6lkrehi 4937 4 final final JJ cord-335975-m6lkrehi 4937 5 results result NNS cord-335975-m6lkrehi 4937 6 , , , cord-335975-m6lkrehi 4937 7 we -PRON- PRP cord-335975-m6lkrehi 4937 8 simulated simulate VBD cord-335975-m6lkrehi 4937 9 individualized individualized JJ cord-335975-m6lkrehi 4937 10 dosing dose VBG cord-335975-m6lkrehi 4937 11 regimens regimen NNS cord-335975-m6lkrehi 4937 12 within within IN cord-335975-m6lkrehi 4937 13 4 4 CD cord-335975-m6lkrehi 4937 14 h h NN cord-335975-m6lkrehi 4937 15 following follow VBG cord-335975-m6lkrehi 4937 16 the the DT cord-335975-m6lkrehi 4937 17 first first JJ cord-335975-m6lkrehi 4937 18 administration administration NN cord-335975-m6lkrehi 4937 19 . . . cord-335975-m6lkrehi 4938 1 More More JJR cord-335975-m6lkrehi 4938 2 than than IN cord-335975-m6lkrehi 4938 3 100 100 CD cord-335975-m6lkrehi 4938 4 IU IU NNP cord-335975-m6lkrehi 4938 5 kg kg NNS cord-335975-m6lkrehi 4939 1 12 12 CD cord-335975-m6lkrehi 4939 2 h h NN cord-335975-m6lkrehi 4939 3 are be VBP cord-335975-m6lkrehi 4939 4 suggested suggest VBN cord-335975-m6lkrehi 4939 5 to to TO cord-335975-m6lkrehi 4939 6 reach reach VB cord-335975-m6lkrehi 4939 7 the the DT cord-335975-m6lkrehi 4939 8 target target NN cord-335975-m6lkrehi 4939 9 range range NN cord-335975-m6lkrehi 4939 10 of of IN cord-335975-m6lkrehi 4939 11 anti anti JJ cord-335975-m6lkrehi 4939 12 - - JJ cord-335975-m6lkrehi 4939 13 Xa xa JJ cord-335975-m6lkrehi 4939 14 activity activity NN cord-335975-m6lkrehi 4939 15 of of IN cord-335975-m6lkrehi 4939 16 0.2 0.2 CD cord-335975-m6lkrehi 4939 17 to to TO cord-335975-m6lkrehi 4939 18 0.4 0.4 CD cord-335975-m6lkrehi 4939 19 IU IU NNP cord-335975-m6lkrehi 4939 20 mL mL NNP cord-335975-m6lkrehi 4939 21 from from IN cord-335975-m6lkrehi 4939 22 the the DT cord-335975-m6lkrehi 4939 23 first first JJ cord-335975-m6lkrehi 4939 24 day day NN cord-335975-m6lkrehi 4939 25 . . . cord-335975-m6lkrehi 4940 1 Standard standard NN cord-335975-m6lkrehi 4940 2 enoxaparin enoxaparin NN cord-335975-m6lkrehi 4940 3 dosing dose VBG cord-335975-m6lkrehi 4940 4 regimens regimen NNS cord-335975-m6lkrehi 4940 5 is be VBZ cord-335975-m6lkrehi 4940 6 not not RB cord-335975-m6lkrehi 4940 7 appropriate appropriate JJ cord-335975-m6lkrehi 4940 8 to to TO cord-335975-m6lkrehi 4940 9 reach reach VB cord-335975-m6lkrehi 4940 10 the the DT cord-335975-m6lkrehi 4940 11 target target NN cord-335975-m6lkrehi 4940 12 in in IN cord-335975-m6lkrehi 4940 13 pediatric pediatric JJ cord-335975-m6lkrehi 4940 14 liver liver NN cord-335975-m6lkrehi 4940 15 transplantation transplantation NN cord-335975-m6lkrehi 4940 16 patients patient NNS cord-335975-m6lkrehi 4940 17 . . . cord-335975-m6lkrehi 4941 1 Enoxaparin Enoxaparin NNP cord-335975-m6lkrehi 4941 2 PK PK NNP cord-335975-m6lkrehi 4941 3 modeling modeling NN cord-335975-m6lkrehi 4941 4 should should MD cord-335975-m6lkrehi 4941 5 help help VB cord-335975-m6lkrehi 4941 6 the the DT cord-335975-m6lkrehi 4941 7 physician physician NN cord-335975-m6lkrehi 4941 8 to to TO cord-335975-m6lkrehi 4941 9 achieve achieve VB cord-335975-m6lkrehi 4941 10 the the DT cord-335975-m6lkrehi 4941 11 target target NN cord-335975-m6lkrehi 4941 12 range range NN cord-335975-m6lkrehi 4941 13 from from IN cord-335975-m6lkrehi 4941 14 the the DT cord-335975-m6lkrehi 4941 15 initial initial JJ cord-335975-m6lkrehi 4941 16 dose dose NN cord-335975-m6lkrehi 4941 17 and and CC cord-335975-m6lkrehi 4941 18 during during IN cord-335975-m6lkrehi 4941 19 the the DT cord-335975-m6lkrehi 4941 20 maintenance maintenance NN cord-335975-m6lkrehi 4941 21 doses dose NNS cord-335975-m6lkrehi 4941 22 . . . cord-335975-m6lkrehi 4942 1 Higher high JJR cord-335975-m6lkrehi 4942 2 dosing dose VBG cord-335975-m6lkrehi 4942 3 regimens regimen NNS cord-335975-m6lkrehi 4942 4 , , , cord-335975-m6lkrehi 4942 5 especially especially RB cord-335975-m6lkrehi 4942 6 in in IN cord-335975-m6lkrehi 4942 7 youngest young JJS cord-335975-m6lkrehi 4942 8 children child NNS cord-335975-m6lkrehi 4942 9 are be VBP cord-335975-m6lkrehi 4942 10 suggested suggest VBN cord-335975-m6lkrehi 4942 11 to to TO cord-335975-m6lkrehi 4942 12 achieve achieve VB cord-335975-m6lkrehi 4942 13 the the DT cord-335975-m6lkrehi 4942 14 prophylactic prophylactic JJ cord-335975-m6lkrehi 4942 15 target target NN cord-335975-m6lkrehi 4942 16 range range NN cord-335975-m6lkrehi 4942 17 . . . cord-335975-m6lkrehi 4943 1 Pharmacokinetic pharmacokinetic JJ cord-335975-m6lkrehi 4943 2 analysis analysis NN cord-335975-m6lkrehi 4943 3 of of IN cord-335975-m6lkrehi 4943 4 unfractionated unfractionated JJ cord-335975-m6lkrehi 4943 5 heparin heparin NNP cord-335975-m6lkrehi 4943 6 in in IN cord-335975-m6lkrehi 4943 7 critically critically RB cord-335975-m6lkrehi 4943 8 ill ill JJ cord-335975-m6lkrehi 4943 9 children child NNS cord-335975-m6lkrehi 4943 10 during during IN cord-335975-m6lkrehi 4943 11 extracorporeal extracorporeal JJ cord-335975-m6lkrehi 4943 12 membrane membrane NN cord-335975-m6lkrehi 4943 13 oxygenation oxygenation NN cord-335975-m6lkrehi 4943 14 : : : cord-335975-m6lkrehi 4943 15 Do do VBP cord-335975-m6lkrehi 4943 16 we -PRON- PRP cord-335975-m6lkrehi 4943 17 achieve achieve VB cord-335975-m6lkrehi 4943 18 the the DT cord-335975-m6lkrehi 4943 19 target target NN cord-335975-m6lkrehi 4943 20 ? ? . cord-335975-m6lkrehi 4944 1 Introduction introduction NN cord-335975-m6lkrehi 4944 2 : : : cord-335975-m6lkrehi 4944 3 Preventing prevent VBG cord-335975-m6lkrehi 4944 4 thrombosis thrombosis NN cord-335975-m6lkrehi 4944 5 in in IN cord-335975-m6lkrehi 4944 6 children child NNS cord-335975-m6lkrehi 4944 7 under under IN cord-335975-m6lkrehi 4944 8 extracorporeal extracorporeal JJ cord-335975-m6lkrehi 4944 9 membrane membrane NN cord-335975-m6lkrehi 4944 10 oxygenation oxygenation NN cord-335975-m6lkrehi 4944 11 ( ( -LRB- cord-335975-m6lkrehi 4944 12 ECMO ECMO NNP cord-335975-m6lkrehi 4944 13 ) ) -RRB- cord-335975-m6lkrehi 4944 14 requiring require VBG cord-335975-m6lkrehi 4944 15 unfractionated unfractionate VBN cord-335975-m6lkrehi 4944 16 heparin heparin NNP cord-335975-m6lkrehi 4944 17 administration administration NN cord-335975-m6lkrehi 4944 18 . . . cord-335975-m6lkrehi 4945 1 Unfractionated unfractionated JJ cord-335975-m6lkrehi 4945 2 heparin heparin NN cord-335975-m6lkrehi 4945 3 pharmacokinetics pharmacokinetic NNS cord-335975-m6lkrehi 4945 4 ( ( -LRB- cord-335975-m6lkrehi 4945 5 PK PK NNP cord-335975-m6lkrehi 4945 6 ) ) -RRB- cord-335975-m6lkrehi 4945 7 has have VBZ cord-335975-m6lkrehi 4945 8 not not RB cord-335975-m6lkrehi 4945 9 been be VBN cord-335975-m6lkrehi 4945 10 well well RB cord-335975-m6lkrehi 4945 11 investigated investigate VBN cord-335975-m6lkrehi 4945 12 in in IN cord-335975-m6lkrehi 4945 13 children child NNS cord-335975-m6lkrehi 4945 14 under under IN cord-335975-m6lkrehi 4945 15 ECMO ECMO NNP cord-335975-m6lkrehi 4945 16 . . . cord-335975-m6lkrehi 4946 1 We -PRON- PRP cord-335975-m6lkrehi 4946 2 described describe VBD cord-335975-m6lkrehi 4946 3 the the DT cord-335975-m6lkrehi 4946 4 unfractionated unfractionated JJ cord-335975-m6lkrehi 4946 5 heparin heparin NNP cord-335975-m6lkrehi 4946 6 dosing dose VBG cord-335975-m6lkrehi 4946 7 regimens regimen NNS cord-335975-m6lkrehi 4946 8 and and CC cord-335975-m6lkrehi 4946 9 resulting result VBG cord-335975-m6lkrehi 4946 10 anti anti JJ cord-335975-m6lkrehi 4946 11 - - JJ cord-335975-m6lkrehi 4946 12 Xa xa JJ cord-335975-m6lkrehi 4946 13 activities activity NNS cord-335975-m6lkrehi 4946 14 in in IN cord-335975-m6lkrehi 4946 15 children child NNS cord-335975-m6lkrehi 4946 16 with with IN cord-335975-m6lkrehi 4946 17 ECMO ECMO NNP cord-335975-m6lkrehi 4946 18 . . . cord-335975-m6lkrehi 4947 1 Patients patient NNS cord-335975-m6lkrehi 4947 2 and and CC cord-335975-m6lkrehi 4947 3 methods method NNS cord-335975-m6lkrehi 4948 1 : : : cord-335975-m6lkrehi 4948 2 This this DT cord-335975-m6lkrehi 4948 3 is be VBZ cord-335975-m6lkrehi 4948 4 a a DT cord-335975-m6lkrehi 4948 5 single single JJ cord-335975-m6lkrehi 4948 6 center center NN cord-335975-m6lkrehi 4948 7 retrospective retrospective JJ cord-335975-m6lkrehi 4948 8 study study NN cord-335975-m6lkrehi 4948 9 from from IN cord-335975-m6lkrehi 4948 10 March March NNP cord-335975-m6lkrehi 4948 11 2015 2015 CD cord-335975-m6lkrehi 4948 12 to to IN cord-335975-m6lkrehi 4948 13 September September NNP cord-335975-m6lkrehi 4948 14 2016 2016 CD cord-335975-m6lkrehi 4948 15 . . . cord-335975-m6lkrehi 4949 1 Were be VBD cord-335975-m6lkrehi 4949 2 included include VBN cord-335975-m6lkrehi 4949 3 children child NNS cord-335975-m6lkrehi 4949 4 ( ( -LRB- cord-335975-m6lkrehi 4949 5 < < NNP cord-335975-m6lkrehi 4949 6 18 18 CD cord-335975-m6lkrehi 4949 7 years year NNS cord-335975-m6lkrehi 4949 8 old old JJ cord-335975-m6lkrehi 4949 9 age age NN cord-335975-m6lkrehi 4949 10 ) ) -RRB- cord-335975-m6lkrehi 4949 11 who who WP cord-335975-m6lkrehi 4949 12 were be VBD cord-335975-m6lkrehi 4949 13 under under IN cord-335975-m6lkrehi 4949 14 ECMO ECMO NNP cord-335975-m6lkrehi 4949 15 for for IN cord-335975-m6lkrehi 4949 16 refractory refractory JJ cord-335975-m6lkrehi 4949 17 hemodynamic hemodynamic JJ cord-335975-m6lkrehi 4949 18 failure failure NN cord-335975-m6lkrehi 4949 19 related relate VBN cord-335975-m6lkrehi 4949 20 to to IN cord-335975-m6lkrehi 4949 21 ( ( -LRB- cord-335975-m6lkrehi 4949 22 i i NN cord-335975-m6lkrehi 4949 23 ) ) -RRB- cord-335975-m6lkrehi 4949 24 myocarditis myocarditis NN cord-335975-m6lkrehi 4949 25 or or CC cord-335975-m6lkrehi 4949 26 ( ( -LRB- cord-335975-m6lkrehi 4949 27 ii ii NN cord-335975-m6lkrehi 4949 28 ) ) -RRB- cord-335975-m6lkrehi 4949 29 septic septic JJ cord-335975-m6lkrehi 4949 30 shock shock NN cord-335975-m6lkrehi 4949 31 . . . cord-335975-m6lkrehi 4950 1 Anti Anti NNP cord-335975-m6lkrehi 4950 2 - - JJ cord-335975-m6lkrehi 4950 3 Xa Xa NNP cord-335975-m6lkrehi 4950 4 activity activity NN cord-335975-m6lkrehi 4950 5 timecourses timecourse NNS cord-335975-m6lkrehi 4950 6 were be VBD cord-335975-m6lkrehi 4950 7 analyzed analyze VBN cord-335975-m6lkrehi 4950 8 using use VBG cord-335975-m6lkrehi 4950 9 a a DT cord-335975-m6lkrehi 4950 10 non non JJ cord-335975-m6lkrehi 4950 11 linear linear JJ cord-335975-m6lkrehi 4950 12 mixed mixed JJ cord-335975-m6lkrehi 4950 13 effects effect NNS cord-335975-m6lkrehi 4950 14 approach approach NN cord-335975-m6lkrehi 4950 15 with with IN cord-335975-m6lkrehi 4950 16 Monolix Monolix NNP cord-335975-m6lkrehi 4950 17 version version NN cord-335975-m6lkrehi 4950 18 2016R. 2016r. CD cord-335975-m6lkrehi 4950 19 Results result NNS cord-335975-m6lkrehi 4950 20 : : : cord-335975-m6lkrehi 4950 21 A a DT cord-335975-m6lkrehi 4950 22 total total NN cord-335975-m6lkrehi 4950 23 of of IN cord-335975-m6lkrehi 4950 24 12 12 CD cord-335975-m6lkrehi 4950 25 children child NNS cord-335975-m6lkrehi 4950 26 were be VBD cord-335975-m6lkrehi 4950 27 included include VBN cord-335975-m6lkrehi 4950 28 ( ( -LRB- cord-335975-m6lkrehi 4950 29 septic septic JJ cord-335975-m6lkrehi 4950 30 shock shock NN cord-335975-m6lkrehi 4950 31 , , , cord-335975-m6lkrehi 4950 32 n n NN cord-335975-m6lkrehi 4950 33 = = SYM cord-335975-m6lkrehi 4950 34 6 6 CD cord-335975-m6lkrehi 4950 35 + + CC cord-335975-m6lkrehi 4950 36 myocarditis myocarditis NN cord-335975-m6lkrehi 4951 1 + + CC cord-335975-m6lkrehi 4952 1 n n NN cord-335975-m6lkrehi 4952 2 = = SYM cord-335975-m6lkrehi 4952 3 6 6 CD cord-335975-m6lkrehi 4952 4 with with IN cord-335975-m6lkrehi 4952 5 a a DT cord-335975-m6lkrehi 4952 6 median median JJ cord-335975-m6lkrehi 4952 7 age age NN cord-335975-m6lkrehi 4952 8 of of IN cord-335975-m6lkrehi 4952 9 42 42 CD cord-335975-m6lkrehi 4952 10 months month NNS cord-335975-m6lkrehi 4952 11 ( ( -LRB- cord-335975-m6lkrehi 4952 12 0 0 CD cord-335975-m6lkrehi 4952 13 - - SYM cord-335975-m6lkrehi 4952 14 197 197 CD cord-335975-m6lkrehi 4952 15 ) ) -RRB- cord-335975-m6lkrehi 4952 16 , , , cord-335975-m6lkrehi 4952 17 a a DT cord-335975-m6lkrehi 4952 18 median median JJ cord-335975-m6lkrehi 4952 19 weight weight NN cord-335975-m6lkrehi 4952 20 of of IN cord-335975-m6lkrehi 4952 21 17.7 17.7 CD cord-335975-m6lkrehi 4952 22 kg kg NNS cord-335975-m6lkrehi 4952 23 ( ( -LRB- cord-335975-m6lkrehi 4952 24 4.9 4.9 CD cord-335975-m6lkrehi 4952 25 - - SYM cord-335975-m6lkrehi 4952 26 69 69 CD cord-335975-m6lkrehi 4952 27 ) ) -RRB- cord-335975-m6lkrehi 4952 28 and and CC cord-335975-m6lkrehi 4952 29 median median JJ cord-335975-m6lkrehi 4952 30 admission admission NN cord-335975-m6lkrehi 4952 31 PELOD-2 PELOD-2 NNP cord-335975-m6lkrehi 4952 32 score score NN cord-335975-m6lkrehi 4952 33 of of IN cord-335975-m6lkrehi 4952 34 11 11 CD cord-335975-m6lkrehi 4952 35 ( ( -LRB- cord-335975-m6lkrehi 4952 36 6 6 CD cord-335975-m6lkrehi 4952 37 - - SYM cord-335975-m6lkrehi 4952 38 21 21 CD cord-335975-m6lkrehi 4952 39 ) ) -RRB- cord-335975-m6lkrehi 4952 40 . . . cord-335975-m6lkrehi 4953 1 Bleeding bleed VBG cord-335975-m6lkrehi 4953 2 occurred occur VBD cord-335975-m6lkrehi 4953 3 in in IN cord-335975-m6lkrehi 4953 4 2 2 CD cord-335975-m6lkrehi 4953 5 children child NNS cord-335975-m6lkrehi 4953 6 and and CC cord-335975-m6lkrehi 4953 7 thrombosis thrombosis NN cord-335975-m6lkrehi 4953 8 in in IN cord-335975-m6lkrehi 4953 9 4 4 CD cord-335975-m6lkrehi 4953 10 . . . cord-335975-m6lkrehi 4954 1 An an DT cord-335975-m6lkrehi 4954 2 initial initial JJ cord-335975-m6lkrehi 4954 3 bolus bolus NN cord-335975-m6lkrehi 4954 4 of of IN cord-335975-m6lkrehi 4954 5 unfractionated unfractionated JJ cord-335975-m6lkrehi 4954 6 heparin heparin NNP cord-335975-m6lkrehi 4954 7 ranging range VBG cord-335975-m6lkrehi 4954 8 from from IN cord-335975-m6lkrehi 4954 9 30 30 CD cord-335975-m6lkrehi 4954 10 to to TO cord-335975-m6lkrehi 4954 11 85 85 CD cord-335975-m6lkrehi 4954 12 IU IU NNP cord-335975-m6lkrehi 4954 13 kg kg NNS cord-335975-m6lkrehi 4954 14 was be VBD cord-335975-m6lkrehi 4954 15 infused infuse VBN cord-335975-m6lkrehi 4954 16 and and CC cord-335975-m6lkrehi 4954 17 then then RB cord-335975-m6lkrehi 4954 18 continued continue VBN cord-335975-m6lkrehi 4954 19 by by IN cord-335975-m6lkrehi 4954 20 continuous continuous JJ cord-335975-m6lkrehi 4954 21 perfusion perfusion NN cord-335975-m6lkrehi 4954 22 with with IN cord-335975-m6lkrehi 4954 23 an an DT cord-335975-m6lkrehi 4954 24 initial initial JJ cord-335975-m6lkrehi 4954 25 dosing dosing NN cord-335975-m6lkrehi 4954 26 ranging range VBG cord-335975-m6lkrehi 4954 27 from from IN cord-335975-m6lkrehi 4954 28 15 15 CD cord-335975-m6lkrehi 4954 29 IU IU NNP cord-335975-m6lkrehi 4954 30 kg kg NNP cord-335975-m6lkrehi 4954 31 h h NN cord-335975-m6lkrehi 4954 32 to to IN cord-335975-m6lkrehi 4954 33 215 215 CD cord-335975-m6lkrehi 4954 34 IU IU NNP cord-335975-m6lkrehi 4954 35 kg kg NNS cord-335975-m6lkrehi 4955 1 h. h. NNP cord-335975-m6lkrehi 4955 2 A A NNP cord-335975-m6lkrehi 4955 3 total total NN cord-335975-m6lkrehi 4955 4 of of IN cord-335975-m6lkrehi 4955 5 214 214 CD cord-335975-m6lkrehi 4955 6 Anti Anti NNP cord-335975-m6lkrehi 4955 7 - - JJ cord-335975-m6lkrehi 4955 8 Xa Xa NNP cord-335975-m6lkrehi 4955 9 activity activity NN cord-335975-m6lkrehi 4955 10 measurements measurement NNS cord-335975-m6lkrehi 4955 11 were be VBD cord-335975-m6lkrehi 4955 12 performed perform VBN cord-335975-m6lkrehi 4955 13 between between IN cord-335975-m6lkrehi 4955 14 1 1 CD cord-335975-m6lkrehi 4955 15 h h NN cord-335975-m6lkrehi 4955 16 empirically empirically RB cord-335975-m6lkrehi 4955 17 antibiotics antibiotic VBZ cord-335975-m6lkrehi 4955 18 for for IN cord-335975-m6lkrehi 4955 19 these these DT cord-335975-m6lkrehi 4955 20 patients patient NNS cord-335975-m6lkrehi 4955 21 with with IN cord-335975-m6lkrehi 4955 22 severe severe JJ cord-335975-m6lkrehi 4955 23 infection infection NN cord-335975-m6lkrehi 4955 24 may may MD cord-335975-m6lkrehi 4955 25 be be VB cord-335975-m6lkrehi 4955 26 recommended recommend VBN cord-335975-m6lkrehi 4955 27 . . . cord-335975-m6lkrehi 4956 1 Introduction introduction NN cord-335975-m6lkrehi 4956 2 : : : cord-335975-m6lkrehi 4956 3 Prognosis prognosis NN cord-335975-m6lkrehi 4956 4 of of IN cord-335975-m6lkrehi 4957 1 allogeneic allogeneic JJ cord-335975-m6lkrehi 4957 2 hematopoietic hematopoietic JJ cord-335975-m6lkrehi 4957 3 stem stem NN cord-335975-m6lkrehi 4957 4 cell cell NN cord-335975-m6lkrehi 4957 5 transplant transplant NN cord-335975-m6lkrehi 4957 6 ( ( -LRB- cord-335975-m6lkrehi 4957 7 HSCT HSCT NNP cord-335975-m6lkrehi 4957 8 ) ) -RRB- cord-335975-m6lkrehi 4957 9 recipients recipient NNS cord-335975-m6lkrehi 4957 10 admitted admit VBN cord-335975-m6lkrehi 4957 11 to to IN cord-335975-m6lkrehi 4957 12 ICU ICU NNP cord-335975-m6lkrehi 4957 13 has have VBZ cord-335975-m6lkrehi 4957 14 improved improve VBN cord-335975-m6lkrehi 4957 15 with with IN cord-335975-m6lkrehi 4957 16 advances advance NNS cord-335975-m6lkrehi 4957 17 in in IN cord-335975-m6lkrehi 4957 18 HSCT HSCT NNP cord-335975-m6lkrehi 4957 19 procedures procedure NNS cord-335975-m6lkrehi 4957 20 and and CC cord-335975-m6lkrehi 4957 21 critical critical JJ cord-335975-m6lkrehi 4957 22 care care NN cord-335975-m6lkrehi 4957 23 management management NN cord-335975-m6lkrehi 4957 24 , , , cord-335975-m6lkrehi 4957 25 but but CC cord-335975-m6lkrehi 4957 26 also also RB cord-335975-m6lkrehi 4957 27 with with IN cord-335975-m6lkrehi 4957 28 evolution evolution NN cord-335975-m6lkrehi 4957 29 in in IN cord-335975-m6lkrehi 4957 30 ICU ICU NNP cord-335975-m6lkrehi 4957 31 triage triage NN cord-335975-m6lkrehi 4957 32 policy policy NN cord-335975-m6lkrehi 4957 33 . . . cord-335975-m6lkrehi 4958 1 Our -PRON- PRP$ cord-335975-m6lkrehi 4958 2 aim aim NN cord-335975-m6lkrehi 4958 3 was be VBD cord-335975-m6lkrehi 4958 4 to to TO cord-335975-m6lkrehi 4958 5 describe describe VB cord-335975-m6lkrehi 4958 6 the the DT cord-335975-m6lkrehi 4958 7 outcome outcome NN cord-335975-m6lkrehi 4958 8 of of IN cord-335975-m6lkrehi 4958 9 HSCT HSCT NNP cord-335975-m6lkrehi 4958 10 recipients recipient NNS cord-335975-m6lkrehi 4958 11 admitted admit VBN cord-335975-m6lkrehi 4958 12 to to IN cord-335975-m6lkrehi 4958 13 ICU ICU NNP cord-335975-m6lkrehi 4958 14 according accord VBG cord-335975-m6lkrehi 4958 15 to to IN cord-335975-m6lkrehi 4958 16 a a DT cord-335975-m6lkrehi 4958 17 wide wide JJ cord-335975-m6lkrehi 4958 18 admission admission NN cord-335975-m6lkrehi 4958 19 policy policy NN cord-335975-m6lkrehi 4958 20 . . . cord-335975-m6lkrehi 4959 1 Patients patient NNS cord-335975-m6lkrehi 4959 2 and and CC cord-335975-m6lkrehi 4959 3 methods method NNS cord-335975-m6lkrehi 4959 4 : : : cord-335975-m6lkrehi 4959 5 Retrospective retrospective JJ cord-335975-m6lkrehi 4959 6 multicenter multicenter JJ cord-335975-m6lkrehi 4959 7 study study NN cord-335975-m6lkrehi 4959 8 including include VBG cord-335975-m6lkrehi 4959 9 all all DT cord-335975-m6lkrehi 4959 10 consecutive consecutive JJ cord-335975-m6lkrehi 4959 11 allogeneic allogeneic NN cord-335975-m6lkrehi 4959 12 hematopoietic hematopoietic JJ cord-335975-m6lkrehi 4959 13 stem stem NN cord-335975-m6lkrehi 4959 14 cell cell NN cord-335975-m6lkrehi 4959 15 transplant transplant NN cord-335975-m6lkrehi 4959 16 ( ( -LRB- cord-335975-m6lkrehi 4959 17 HSCT HSCT NNP cord-335975-m6lkrehi 4959 18 ) ) -RRB- cord-335975-m6lkrehi 4959 19 recipients recipient NNS cord-335975-m6lkrehi 4959 20 admitted admit VBN cord-335975-m6lkrehi 4959 21 to to IN cord-335975-m6lkrehi 4959 22 Saint Saint NNP cord-335975-m6lkrehi 4959 23 - - HYPH cord-335975-m6lkrehi 4959 24 Antoine Antoine NNP cord-335975-m6lkrehi 4959 25 hospital hospital NN cord-335975-m6lkrehi 4959 26 medical medical JJ cord-335975-m6lkrehi 4959 27 ICU ICU NNP cord-335975-m6lkrehi 4959 28 , , , cord-335975-m6lkrehi 4959 29 Paris Paris NNP cord-335975-m6lkrehi 4959 30 , , , cord-335975-m6lkrehi 4959 31 France France NNP cord-335975-m6lkrehi 4959 32 from from IN cord-335975-m6lkrehi 4959 33 to to IN cord-335975-m6lkrehi 4959 34 January January NNP cord-335975-m6lkrehi 4959 35 2005 2005 CD cord-335975-m6lkrehi 4959 36 to to IN cord-335975-m6lkrehi 4959 37 April April NNP cord-335975-m6lkrehi 4959 38 2017 2017 CD cord-335975-m6lkrehi 4959 39 . . . cord-335975-m6lkrehi 4960 1 Admissions admission NNS cord-335975-m6lkrehi 4960 2 were be VBD cord-335975-m6lkrehi 4960 3 identified identify VBN cord-335975-m6lkrehi 4960 4 through through IN cord-335975-m6lkrehi 4960 5 a a DT cord-335975-m6lkrehi 4960 6 systematic systematic JJ cord-335975-m6lkrehi 4960 7 review review NN cord-335975-m6lkrehi 4960 8 of of IN cord-335975-m6lkrehi 4960 9 ICU ICU NNP cord-335975-m6lkrehi 4960 10 database database NN cord-335975-m6lkrehi 4960 11 using use VBG cord-335975-m6lkrehi 4960 12 ICD-10 ICD-10 `` cord-335975-m6lkrehi 4960 13 codes code NNS cord-335975-m6lkrehi 4960 14 Z948 Z948 NNS cord-335975-m6lkrehi 4960 15 and and CC cord-335975-m6lkrehi 4960 16 T860 T860 NNS cord-335975-m6lkrehi 4960 17 . . . cord-335975-m6lkrehi 4961 1 Data datum NNS cord-335975-m6lkrehi 4961 2 were be VBD cord-335975-m6lkrehi 4961 3 extracted extract VBN cord-335975-m6lkrehi 4961 4 from from IN cord-335975-m6lkrehi 4961 5 medical medical JJ cord-335975-m6lkrehi 4961 6 charts chart NNS cord-335975-m6lkrehi 4961 7 . . . cord-335975-m6lkrehi 4962 1 Qualitative qualitative JJ cord-335975-m6lkrehi 4962 2 and and CC cord-335975-m6lkrehi 4962 3 quantitative quantitative JJ cord-335975-m6lkrehi 4962 4 values value NNS cord-335975-m6lkrehi 4962 5 are be VBP cord-335975-m6lkrehi 4962 6 expressed express VBN cord-335975-m6lkrehi 4962 7 as as IN cord-335975-m6lkrehi 4962 8 number number NN cord-335975-m6lkrehi 4962 9 and and CC cord-335975-m6lkrehi 4962 10 percentage percentage NN cord-335975-m6lkrehi 4962 11 , , , cord-335975-m6lkrehi 4962 12 and and CC cord-335975-m6lkrehi 4962 13 median median NN cord-335975-m6lkrehi 4962 14 and and CC cord-335975-m6lkrehi 4962 15 interquartile interquartile JJ cord-335975-m6lkrehi 4962 16 range range NN cord-335975-m6lkrehi 4962 17 , , , cord-335975-m6lkrehi 4962 18 respectively respectively RB cord-335975-m6lkrehi 4962 19 . . . cord-335975-m6lkrehi 4963 1 Comparisons comparison NNS cord-335975-m6lkrehi 4963 2 between between IN cord-335975-m6lkrehi 4963 3 groups group NNS cord-335975-m6lkrehi 4963 4 were be VBD cord-335975-m6lkrehi 4963 5 performed perform VBN cord-335975-m6lkrehi 4963 6 using use VBG cord-335975-m6lkrehi 4963 7 Fisher Fisher NNP cord-335975-m6lkrehi 4963 8 's 's POS cord-335975-m6lkrehi 4963 9 exact exact JJ cord-335975-m6lkrehi 4963 10 test test NN cord-335975-m6lkrehi 4963 11 and and CC cord-335975-m6lkrehi 4963 12 Mann Mann NNP cord-335975-m6lkrehi 4963 13 - - HYPH cord-335975-m6lkrehi 4963 14 Whitney Whitney NNP cord-335975-m6lkrehi 4963 15 test test NN cord-335975-m6lkrehi 4963 16 for for IN cord-335975-m6lkrehi 4963 17 qualitative qualitative JJ cord-335975-m6lkrehi 4963 18 and and CC cord-335975-m6lkrehi 4963 19 quantitative quantitative JJ cord-335975-m6lkrehi 4963 20 variables variable NNS cord-335975-m6lkrehi 4963 21 , , , cord-335975-m6lkrehi 4963 22 respectively respectively RB cord-335975-m6lkrehi 4963 23 . . . cord-335975-m6lkrehi 4964 1 A a DT cord-335975-m6lkrehi 4964 2 p p NN cord-335975-m6lkrehi 4964 3 - - HYPH cord-335975-m6lkrehi 4964 4 value value NN cord-335975-m6lkrehi 4964 5 < < XX cord-335975-m6lkrehi 4964 6 0.05 0.05 CD cord-335975-m6lkrehi 4964 7 was be VBD cord-335975-m6lkrehi 4964 8 considered consider VBN cord-335975-m6lkrehi 4964 9 to to TO cord-335975-m6lkrehi 4964 10 be be VB cord-335975-m6lkrehi 4964 11 significant significant JJ cord-335975-m6lkrehi 4964 12 . . . cord-335975-m6lkrehi 4965 1 Results result NNS cord-335975-m6lkrehi 4965 2 : : : cord-335975-m6lkrehi 4966 1 One one CD cord-335975-m6lkrehi 4966 2 hundred hundred CD cord-335975-m6lkrehi 4966 3 seventeen seventeen CD cord-335975-m6lkrehi 4966 4 patients-77 patients-77 NN cord-335975-m6lkrehi 4966 5 men man NNS cord-335975-m6lkrehi 4966 6 ( ( -LRB- cord-335975-m6lkrehi 4966 7 65.8 65.8 CD cord-335975-m6lkrehi 4966 8 % % NN cord-335975-m6lkrehi 4966 9 ) ) -RRB- cord-335975-m6lkrehi 4966 10 , , , cord-335975-m6lkrehi 4966 11 median median JJ cord-335975-m6lkrehi 4966 12 age age NN cord-335975-m6lkrehi 4966 13 53 53 CD cord-335975-m6lkrehi 4966 14 [ [ -LRB- cord-335975-m6lkrehi 4966 15 36 36 CD cord-335975-m6lkrehi 4966 16 - - SYM cord-335975-m6lkrehi 4966 17 63 63 CD cord-335975-m6lkrehi 4966 18 ] ] -RRB- cord-335975-m6lkrehi 4966 19 years year NNS cord-335975-m6lkrehi 4966 20 - - , cord-335975-m6lkrehi 4966 21 were be VBD cord-335975-m6lkrehi 4966 22 included include VBN cord-335975-m6lkrehi 4966 23 in in IN cord-335975-m6lkrehi 4966 24 the the DT cord-335975-m6lkrehi 4966 25 study study NN cord-335975-m6lkrehi 4966 26 . . . cord-335975-m6lkrehi 4967 1 Underlying underlying JJ cord-335975-m6lkrehi 4967 2 hematological hematological JJ cord-335975-m6lkrehi 4967 3 malignancies malignancy NNS cord-335975-m6lkrehi 4967 4 were be VBD cord-335975-m6lkrehi 4967 5 : : : cord-335975-m6lkrehi 4967 6 acute acute JJ cord-335975-m6lkrehi 4967 7 myeloid myeloid NN cord-335975-m6lkrehi 4967 8 leukemia leukemia NN cord-335975-m6lkrehi 4967 9 ( ( -LRB- cord-335975-m6lkrehi 4967 10 n n NN cord-335975-m6lkrehi 4967 11 = = SYM cord-335975-m6lkrehi 4967 12 51 51 CD cord-335975-m6lkrehi 4967 13 , , , cord-335975-m6lkrehi 4967 14 43.6 43.6 CD cord-335975-m6lkrehi 4967 15 % % NN cord-335975-m6lkrehi 4967 16 ) ) -RRB- cord-335975-m6lkrehi 4967 17 , , . cord-335975-m6lkrehi 4968 1 myelodysplastic myelodysplastic JJ cord-335975-m6lkrehi 4968 2 / / SYM cord-335975-m6lkrehi 4968 3 myeloproliferative myeloproliferative JJ cord-335975-m6lkrehi 4968 4 neoplasms neoplasm NNS cord-335975-m6lkrehi 4968 5 ( ( -LRB- cord-335975-m6lkrehi 4969 1 n n NN cord-335975-m6lkrehi 4969 2 = = SYM cord-335975-m6lkrehi 4969 3 22 22 CD cord-335975-m6lkrehi 4969 4 , , , cord-335975-m6lkrehi 4969 5 18.8 18.8 CD cord-335975-m6lkrehi 4969 6 % % NN cord-335975-m6lkrehi 4969 7 ) ) -RRB- cord-335975-m6lkrehi 4969 8 , , . cord-335975-m6lkrehi 4970 1 acute acute JJ cord-335975-m6lkrehi 4970 2 lymphoid lymphoid JJ cord-335975-m6lkrehi 4970 3 leukemia leukemia NN cord-335975-m6lkrehi 4970 4 ( ( -LRB- cord-335975-m6lkrehi 4970 5 n n NN cord-335975-m6lkrehi 4970 6 = = SYM cord-335975-m6lkrehi 4970 7 22 22 CD cord-335975-m6lkrehi 4970 8 , , , cord-335975-m6lkrehi 4970 9 18.8 18.8 CD cord-335975-m6lkrehi 4970 10 % % NN cord-335975-m6lkrehi 4970 11 ) ) -RRB- cord-335975-m6lkrehi 4970 12 , , , cord-335975-m6lkrehi 4970 13 lymphoma lymphoma NN cord-335975-m6lkrehi 4970 14 ( ( -LRB- cord-335975-m6lkrehi 4970 15 n n NN cord-335975-m6lkrehi 4970 16 = = SYM cord-335975-m6lkrehi 4970 17 11 11 CD cord-335975-m6lkrehi 4970 18 , , , cord-335975-m6lkrehi 4970 19 9.4 9.4 CD cord-335975-m6lkrehi 4970 20 % % NN cord-335975-m6lkrehi 4970 21 ) ) -RRB- cord-335975-m6lkrehi 4970 22 , , , cord-335975-m6lkrehi 4970 23 other other JJ cord-335975-m6lkrehi 4970 24 11 11 CD cord-335975-m6lkrehi 4970 25 ( ( -LRB- cord-335975-m6lkrehi 4970 26 9.4 9.4 CD cord-335975-m6lkrehi 4970 27 % % NN cord-335975-m6lkrehi 4970 28 ) ) -RRB- cord-335975-m6lkrehi 4970 29 . . . cord-335975-m6lkrehi 4971 1 Complete complete JJ cord-335975-m6lkrehi 4971 2 remission remission NN cord-335975-m6lkrehi 4971 3 was be VBD cord-335975-m6lkrehi 4971 4 achieved achieve VBN cord-335975-m6lkrehi 4971 5 before before IN cord-335975-m6lkrehi 4971 6 HSCT HSCT NNP cord-335975-m6lkrehi 4971 7 in in IN cord-335975-m6lkrehi 4971 8 61 61 CD cord-335975-m6lkrehi 4971 9 ( ( -LRB- cord-335975-m6lkrehi 4971 10 56 56 CD cord-335975-m6lkrehi 4971 11 % % NN cord-335975-m6lkrehi 4971 12 ) ) -RRB- cord-335975-m6lkrehi 4971 13 patients patient NNS cord-335975-m6lkrehi 4971 14 . . . cord-335975-m6lkrehi 4972 1 Forty forty CD cord-335975-m6lkrehi 4972 2 - - HYPH cord-335975-m6lkrehi 4972 3 nine nine CD cord-335975-m6lkrehi 4972 4 ( ( -LRB- cord-335975-m6lkrehi 4972 5 46.2 46.2 CD cord-335975-m6lkrehi 4972 6 % % NN cord-335975-m6lkrehi 4972 7 ) ) -RRB- cord-335975-m6lkrehi 4972 8 patients patient NNS cord-335975-m6lkrehi 4972 9 underwent undergo VBD cord-335975-m6lkrehi 4972 10 myeloablative myeloablative NNP cord-335975-m6lkrehi 4972 11 conditioning conditioning NNP cord-335975-m6lkrehi 4972 12 regimen regimen NN cord-335975-m6lkrehi 4972 13 and and CC cord-335975-m6lkrehi 4972 14 23 23 CD cord-335975-m6lkrehi 4972 15 ( ( -LRB- cord-335975-m6lkrehi 4972 16 21.1 21.1 CD cord-335975-m6lkrehi 4972 17 % % NN cord-335975-m6lkrehi 4972 18 ) ) -RRB- cord-335975-m6lkrehi 4972 19 received receive VBD cord-335975-m6lkrehi 4972 20 haploidentical haploidentical JJ cord-335975-m6lkrehi 4972 21 grafts graft NNS cord-335975-m6lkrehi 4972 22 . . . cord-335975-m6lkrehi 4973 1 Twenty twenty CD cord-335975-m6lkrehi 4973 2 - - HYPH cord-335975-m6lkrehi 4973 3 eight eight CD cord-335975-m6lkrehi 4973 4 ( ( -LRB- cord-335975-m6lkrehi 4973 5 23.9 23.9 CD cord-335975-m6lkrehi 4973 6 % % NN cord-335975-m6lkrehi 4973 7 ) ) -RRB- cord-335975-m6lkrehi 4973 8 patients patient NNS cord-335975-m6lkrehi 4973 9 experienced experience VBD cord-335975-m6lkrehi 4973 10 disease disease NN cord-335975-m6lkrehi 4973 11 relapse relapse NN cord-335975-m6lkrehi 4973 12 after after IN cord-335975-m6lkrehi 4973 13 HSCT HSCT NNP cord-335975-m6lkrehi 4973 14 and and CC cord-335975-m6lkrehi 4973 15 48 48 CD cord-335975-m6lkrehi 4973 16 ( ( -LRB- cord-335975-m6lkrehi 4973 17 41 41 CD cord-335975-m6lkrehi 4973 18 % % NN cord-335975-m6lkrehi 4973 19 ) ) -RRB- cord-335975-m6lkrehi 4973 20 graft graft NN cord-335975-m6lkrehi 4973 21 versus versus IN cord-335975-m6lkrehi 4973 22 host host NN cord-335975-m6lkrehi 4973 23 disease disease NN cord-335975-m6lkrehi 4973 24 prior prior IN cord-335975-m6lkrehi 4973 25 ICU ICU NNP cord-335975-m6lkrehi 4973 26 admission admission NN cord-335975-m6lkrehi 4973 27 . . . cord-335975-m6lkrehi 4974 1 Median median JJ cord-335975-m6lkrehi 4974 2 SAPS SAPS NNP cord-335975-m6lkrehi 4974 3 II II NNP cord-335975-m6lkrehi 4974 4 was be VBD cord-335975-m6lkrehi 4974 5 49 49 CD cord-335975-m6lkrehi 4974 6 and and CC cord-335975-m6lkrehi 4974 7 SOFA sofa NN cord-335975-m6lkrehi 4974 8 score score NN cord-335975-m6lkrehi 4974 9 at at IN cord-335975-m6lkrehi 4974 10 day day NN cord-335975-m6lkrehi 4974 11 one one CD cord-335975-m6lkrehi 4974 12 9 9 CD cord-335975-m6lkrehi 4974 13 [ [ -LRB- cord-335975-m6lkrehi 4974 14 6 6 CD cord-335975-m6lkrehi 4974 15 - - SYM cord-335975-m6lkrehi 4974 16 11 11 CD cord-335975-m6lkrehi 4974 17 ] ] -RRB- cord-335975-m6lkrehi 4974 18 . . . cord-335975-m6lkrehi 4975 1 The the DT cord-335975-m6lkrehi 4975 2 ICU ICU NNP cord-335975-m6lkrehi 4975 3 , , , cord-335975-m6lkrehi 4975 4 hospital hospital NN cord-335975-m6lkrehi 4975 5 and and CC cord-335975-m6lkrehi 4975 6 90-day 90-day CD cord-335975-m6lkrehi 4975 7 mortality mortality NN cord-335975-m6lkrehi 4975 8 rates rate NNS cord-335975-m6lkrehi 4975 9 were be VBD cord-335975-m6lkrehi 4975 10 respectively respectively RB cord-335975-m6lkrehi 4975 11 38.5 38.5 CD cord-335975-m6lkrehi 4975 12 , , , cord-335975-m6lkrehi 4975 13 54.9 54.9 CD cord-335975-m6lkrehi 4975 14 and and CC cord-335975-m6lkrehi 4975 15 57.5 57.5 CD cord-335975-m6lkrehi 4975 16 % % NN cord-335975-m6lkrehi 4975 17 . . . cord-335975-m6lkrehi 4976 1 In in IN cord-335975-m6lkrehi 4976 2 univariate univariate JJ cord-335975-m6lkrehi 4976 3 analysis analysis NN cord-335975-m6lkrehi 4976 4 , , , cord-335975-m6lkrehi 4976 5 factors factor NNS cord-335975-m6lkrehi 4976 6 associated associate VBN cord-335975-m6lkrehi 4976 7 with with IN cord-335975-m6lkrehi 4976 8 90-day 90-day CD cord-335975-m6lkrehi 4976 9 mortality mortality NN cord-335975-m6lkrehi 4976 10 were be VBD cord-335975-m6lkrehi 4976 11 : : : cord-335975-m6lkrehi 4976 12 SAPS SAPS NNP cord-335975-m6lkrehi 4976 13 II II NNP cord-335975-m6lkrehi 4976 14 ( ( -LRB- cord-335975-m6lkrehi 4976 15 p p NN cord-335975-m6lkrehi 4976 16 = = SYM cord-335975-m6lkrehi 4976 17 0.0011 0.0011 CD cord-335975-m6lkrehi 4976 18 ) ) -RRB- cord-335975-m6lkrehi 4976 19 , , , cord-335975-m6lkrehi 4976 20 invasive invasive JJ cord-335975-m6lkrehi 4976 21 mechanical mechanical JJ cord-335975-m6lkrehi 4976 22 ventilation ventilation NN cord-335975-m6lkrehi 4976 23 ( ( -LRB- cord-335975-m6lkrehi 4976 24 p p NN cord-335975-m6lkrehi 4976 25 < < XX cord-335975-m6lkrehi 4976 26 0.0001 0.0001 CD cord-335975-m6lkrehi 4976 27 ) ) -RRB- cord-335975-m6lkrehi 4976 28 , , , cord-335975-m6lkrehi 4976 29 vasopressors vasopressor NNS cord-335975-m6lkrehi 4976 30 ( ( -LRB- cord-335975-m6lkrehi 4976 31 p p NN cord-335975-m6lkrehi 4976 32 = = SYM cord-335975-m6lkrehi 4976 33 0.0012 0.0012 CD cord-335975-m6lkrehi 4976 34 ) ) -RRB- cord-335975-m6lkrehi 4976 35 and and CC cord-335975-m6lkrehi 4976 36 renal renal JJ cord-335975-m6lkrehi 4976 37 replacement replacement NN cord-335975-m6lkrehi 4976 38 therapy therapy NN cord-335975-m6lkrehi 4976 39 ( ( -LRB- cord-335975-m6lkrehi 4976 40 p p NN cord-335975-m6lkrehi 4976 41 = = SYM cord-335975-m6lkrehi 4976 42 0.045 0.045 CD cord-335975-m6lkrehi 4976 43 ) ) -RRB- cord-335975-m6lkrehi 4976 44 . . . cord-335975-m6lkrehi 4977 1 Mechanical mechanical JJ cord-335975-m6lkrehi 4977 2 ventilation ventilation NN cord-335975-m6lkrehi 4977 3 was be VBD cord-335975-m6lkrehi 4977 4 the the DT cord-335975-m6lkrehi 4977 5 only only JJ cord-335975-m6lkrehi 4977 6 independent independent JJ cord-335975-m6lkrehi 4977 7 factor factor NN cord-335975-m6lkrehi 4977 8 of of IN cord-335975-m6lkrehi 4977 9 90-day 90-day CD cord-335975-m6lkrehi 4977 10 mortality mortality NN cord-335975-m6lkrehi 4977 11 ( ( -LRB- cord-335975-m6lkrehi 4977 12 OR or CC cord-335975-m6lkrehi 4977 13 2.5 2.5 CD cord-335975-m6lkrehi 4977 14 - - HYPH cord-335975-m6lkrehi 4977 15 16.4 16.4 CD cord-335975-m6lkrehi 4977 16 ] ] -RRB- cord-335975-m6lkrehi 4977 17 , , , cord-335975-m6lkrehi 4977 18 p p NN cord-335975-m6lkrehi 4977 19 < < XX cord-335975-m6lkrehi 4977 20 0.0001 0.0001 CD cord-335975-m6lkrehi 4977 21 ) ) -RRB- cord-335975-m6lkrehi 4977 22 with with IN cord-335975-m6lkrehi 4977 23 mortality mortality NN cord-335975-m6lkrehi 4977 24 rate rate NN cord-335975-m6lkrehi 4977 25 reaching reach VBG cord-335975-m6lkrehi 4977 26 76.9 76.9 CD cord-335975-m6lkrehi 4977 27 % % NN cord-335975-m6lkrehi 4977 28 and and CC cord-335975-m6lkrehi 4977 29 even even RB cord-335975-m6lkrehi 4977 30 86.7 86.7 CD cord-335975-m6lkrehi 4977 31 % % NN cord-335975-m6lkrehi 4977 32 among among IN cord-335975-m6lkrehi 4977 33 patients patient NNS cord-335975-m6lkrehi 4977 34 with with IN cord-335975-m6lkrehi 4977 35 uncontrolled uncontrolled JJ cord-335975-m6lkrehi 4977 36 hematological hematological JJ cord-335975-m6lkrehi 4977 37 disease disease NN cord-335975-m6lkrehi 4977 38 . . . cord-335975-m6lkrehi 4978 1 Conclusion conclusion NN cord-335975-m6lkrehi 4978 2 : : : cord-335975-m6lkrehi 4979 1 Prognosis prognosis NN cord-335975-m6lkrehi 4979 2 of of IN cord-335975-m6lkrehi 4979 3 unselected unselected JJ cord-335975-m6lkrehi 4979 4 HSCT HSCT NNP cord-335975-m6lkrehi 4979 5 recipients recipient NNS cord-335975-m6lkrehi 4979 6 admitted admit VBN cord-335975-m6lkrehi 4979 7 to to IN cord-335975-m6lkrehi 4979 8 ICU ICU NNP cord-335975-m6lkrehi 4979 9 remains remain VBZ cord-335975-m6lkrehi 4979 10 poor poor JJ cord-335975-m6lkrehi 4979 11 , , , cord-335975-m6lkrehi 4979 12 particurlaly particurlaly NNP cord-335975-m6lkrehi 4979 13 among among IN cord-335975-m6lkrehi 4979 14 those those DT cord-335975-m6lkrehi 4979 15 receiving receive VBG cord-335975-m6lkrehi 4979 16 mechanical mechanical JJ cord-335975-m6lkrehi 4979 17 ventilation ventilation NN cord-335975-m6lkrehi 4979 18 , , , cord-335975-m6lkrehi 4979 19 and and CC cord-335975-m6lkrehi 4979 20 even even RB cord-335975-m6lkrehi 4979 21 more more RBR cord-335975-m6lkrehi 4979 22 if if IN cord-335975-m6lkrehi 4979 23 hematological hematological JJ cord-335975-m6lkrehi 4979 24 disease disease NN cord-335975-m6lkrehi 4979 25 is be VBZ cord-335975-m6lkrehi 4979 26 not not RB cord-335975-m6lkrehi 4979 27 controlled control VBN cord-335975-m6lkrehi 4979 28 . . . cord-335975-m6lkrehi 4980 1 These these DT cord-335975-m6lkrehi 4980 2 results result NNS cord-335975-m6lkrehi 4980 3 suggest suggest VBP cord-335975-m6lkrehi 4980 4 that that IN cord-335975-m6lkrehi 4980 5 the the DT cord-335975-m6lkrehi 4980 6 implementation implementation NN cord-335975-m6lkrehi 4980 7 of of IN cord-335975-m6lkrehi 4980 8 an an DT cord-335975-m6lkrehi 4980 9 ICU ICU NNP cord-335975-m6lkrehi 4980 10 triage triage NN cord-335975-m6lkrehi 4980 11 policy policy NN cord-335975-m6lkrehi 4980 12 determined determine VBD cord-335975-m6lkrehi 4980 13 both both CC cord-335975-m6lkrehi 4980 14 by by IN cord-335975-m6lkrehi 4980 15 intensivits intensivit NNS cord-335975-m6lkrehi 4980 16 and and CC cord-335975-m6lkrehi 4980 17 hematologists hematologist NNS cord-335975-m6lkrehi 4980 18 would would MD cord-335975-m6lkrehi 4980 19 be be VB cord-335975-m6lkrehi 4980 20 helpful helpful JJ cord-335975-m6lkrehi 4980 21 to to TO cord-335975-m6lkrehi 4980 22 identify identify VB cord-335975-m6lkrehi 4980 23 good good JJ cord-335975-m6lkrehi 4980 24 candidates candidate NNS cord-335975-m6lkrehi 4980 25 for for IN cord-335975-m6lkrehi 4980 26 ICU ICU NNP cord-335975-m6lkrehi 4980 27 admission admission NN cord-335975-m6lkrehi 4980 28 . . . cord-335975-m6lkrehi 4981 1 Introduction introduction NN cord-335975-m6lkrehi 4981 2 : : : cord-335975-m6lkrehi 4982 1 Acute acute JJ cord-335975-m6lkrehi 4982 2 respiratory respiratory JJ cord-335975-m6lkrehi 4982 3 failure failure NN cord-335975-m6lkrehi 4982 4 ( ( -LRB- cord-335975-m6lkrehi 4982 5 ARF ARF NNP cord-335975-m6lkrehi 4982 6 ) ) -RRB- cord-335975-m6lkrehi 4982 7 is be VBZ cord-335975-m6lkrehi 4982 8 a a DT cord-335975-m6lkrehi 4982 9 common common JJ cord-335975-m6lkrehi 4982 10 event event NN cord-335975-m6lkrehi 4982 11 in in IN cord-335975-m6lkrehi 4982 12 patients patient NNS cord-335975-m6lkrehi 4982 13 with with IN cord-335975-m6lkrehi 4982 14 primary primary JJ cord-335975-m6lkrehi 4982 15 malignant malignant JJ cord-335975-m6lkrehi 4982 16 brain brain NN cord-335975-m6lkrehi 4982 17 tumors tumor NNS cord-335975-m6lkrehi 4982 18 ( ( -LRB- cord-335975-m6lkrehi 4982 19 PMBT PMBT NNP cord-335975-m6lkrehi 4982 20 ) ) -RRB- cord-335975-m6lkrehi 4982 21 . . . cord-335975-m6lkrehi 4983 1 Even even RB cord-335975-m6lkrehi 4983 2 if if IN cord-335975-m6lkrehi 4983 3 many many JJ cord-335975-m6lkrehi 4983 4 factors factor NNS cord-335975-m6lkrehi 4983 5 ( ( -LRB- cord-335975-m6lkrehi 4983 6 corticosteroid corticosteroid NN cord-335975-m6lkrehi 4983 7 therapy therapy NN cord-335975-m6lkrehi 4983 8 , , , cord-335975-m6lkrehi 4983 9 swallowing swallow VBG cord-335975-m6lkrehi 4983 10 disorders disorder NNS cord-335975-m6lkrehi 4983 11 ) ) -RRB- cord-335975-m6lkrehi 4983 12 suggest suggest VBP cord-335975-m6lkrehi 4983 13 a a DT cord-335975-m6lkrehi 4983 14 specific specific JJ cord-335975-m6lkrehi 4983 15 etiologic etiologic JJ cord-335975-m6lkrehi 4983 16 spectrum spectrum NN cord-335975-m6lkrehi 4983 17 , , , cord-335975-m6lkrehi 4983 18 few few JJ cord-335975-m6lkrehi 4983 19 data datum NNS cord-335975-m6lkrehi 4983 20 are be VBP cord-335975-m6lkrehi 4983 21 available available JJ cord-335975-m6lkrehi 4983 22 regarding regard VBG cord-335975-m6lkrehi 4983 23 its -PRON- PRP$ cord-335975-m6lkrehi 4983 24 precipitating precipitate VBG cord-335975-m6lkrehi 4983 25 factors factor NNS cord-335975-m6lkrehi 4983 26 . . . cord-335975-m6lkrehi 4984 1 Our -PRON- PRP$ cord-335975-m6lkrehi 4984 2 first first JJ cord-335975-m6lkrehi 4984 3 aim aim NN cord-335975-m6lkrehi 4984 4 was be VBD cord-335975-m6lkrehi 4984 5 to to TO cord-335975-m6lkrehi 4984 6 compare compare VB cord-335975-m6lkrehi 4984 7 the the DT cord-335975-m6lkrehi 4984 8 causes cause NNS cord-335975-m6lkrehi 4984 9 of of IN cord-335975-m6lkrehi 4984 10 ARF arf NN cord-335975-m6lkrehi 4984 11 between between IN cord-335975-m6lkrehi 4984 12 patients patient NNS cord-335975-m6lkrehi 4984 13 with with IN cord-335975-m6lkrehi 4984 14 PMBT PMBT NNP cord-335975-m6lkrehi 4984 15 and and CC cord-335975-m6lkrehi 4984 16 those those DT cord-335975-m6lkrehi 4984 17 with with IN cord-335975-m6lkrehi 4984 18 other other JJ cord-335975-m6lkrehi 4984 19 type type NN cord-335975-m6lkrehi 4984 20 solid solid JJ cord-335975-m6lkrehi 4984 21 tumors tumor NNS cord-335975-m6lkrehi 4984 22 . . . cord-335975-m6lkrehi 4985 1 Our -PRON- PRP$ cord-335975-m6lkrehi 4985 2 second second JJ cord-335975-m6lkrehi 4985 3 aim aim NN cord-335975-m6lkrehi 4985 4 was be VBD cord-335975-m6lkrehi 4985 5 to to TO cord-335975-m6lkrehi 4985 6 identify identify VB cord-335975-m6lkrehi 4985 7 , , , cord-335975-m6lkrehi 4985 8 among among IN cord-335975-m6lkrehi 4985 9 PMBT PMBT NNP cord-335975-m6lkrehi 4985 10 , , , cord-335975-m6lkrehi 4985 11 the the DT cord-335975-m6lkrehi 4985 12 factors factor NNS cord-335975-m6lkrehi 4985 13 influencing influence VBG cord-335975-m6lkrehi 4985 14 survival survival NN cord-335975-m6lkrehi 4985 15 in in IN cord-335975-m6lkrehi 4985 16 ICU ICU NNP cord-335975-m6lkrehi 4985 17 . . . cord-335975-m6lkrehi 4986 1 Patients patient NNS cord-335975-m6lkrehi 4986 2 and and CC cord-335975-m6lkrehi 4986 3 methods method NNS cord-335975-m6lkrehi 4986 4 : : : cord-335975-m6lkrehi 4986 5 Bicentric Bicentric NNP cord-335975-m6lkrehi 4986 6 case case NN cord-335975-m6lkrehi 4986 7 - - HYPH cord-335975-m6lkrehi 4986 8 control control NN cord-335975-m6lkrehi 4986 9 study study NN cord-335975-m6lkrehi 4986 10 from from IN cord-335975-m6lkrehi 4986 11 March March NNP cord-335975-m6lkrehi 4986 12 1996 1996 CD cord-335975-m6lkrehi 4986 13 to to IN cord-335975-m6lkrehi 4986 14 May May NNP cord-335975-m6lkrehi 4986 15 2014 2014 CD cord-335975-m6lkrehi 4986 16 . . . cord-335975-m6lkrehi 4987 1 Patients patient NNS cord-335975-m6lkrehi 4987 2 with with IN cord-335975-m6lkrehi 4987 3 PMBT PMBT NNP cord-335975-m6lkrehi 4987 4 ( ( -LRB- cord-335975-m6lkrehi 4987 5 cases case NNS cord-335975-m6lkrehi 4987 6 , , , cord-335975-m6lkrehi 4987 7 primary primary JJ cord-335975-m6lkrehi 4987 8 central central JJ cord-335975-m6lkrehi 4987 9 nervous nervous JJ cord-335975-m6lkrehi 4987 10 system system NN cord-335975-m6lkrehi 4987 11 lymphoma lymphoma NN cord-335975-m6lkrehi 4987 12 included include VBD cord-335975-m6lkrehi 4987 13 ) ) -RRB- cord-335975-m6lkrehi 4987 14 admitted admit VBD cord-335975-m6lkrehi 4987 15 for for IN cord-335975-m6lkrehi 4987 16 ARF ARF NNP cord-335975-m6lkrehi 4987 17 were be VBD cord-335975-m6lkrehi 4987 18 compared compare VBN cord-335975-m6lkrehi 4987 19 to to IN cord-335975-m6lkrehi 4987 20 patients patient NNS cord-335975-m6lkrehi 4987 21 with with IN cord-335975-m6lkrehi 4987 22 other other JJ cord-335975-m6lkrehi 4987 23 kind kind NN cord-335975-m6lkrehi 4987 24 of of IN cord-335975-m6lkrehi 4987 25 solid solid JJ cord-335975-m6lkrehi 4987 26 tumors tumor NNS cord-335975-m6lkrehi 4987 27 ( ( -LRB- cord-335975-m6lkrehi 4987 28 controls control NNS cord-335975-m6lkrehi 4987 29 ) ) -RRB- cord-335975-m6lkrehi 4987 30 . . . cord-335975-m6lkrehi 4988 1 The the DT cord-335975-m6lkrehi 4988 2 reason reason NN cord-335975-m6lkrehi 4988 3 for for IN cord-335975-m6lkrehi 4988 4 admission admission NN cord-335975-m6lkrehi 4988 5 " " `` cord-335975-m6lkrehi 4988 6 ARF arf NN cord-335975-m6lkrehi 4988 7 " " '' cord-335975-m6lkrehi 4988 8 as as RB cord-335975-m6lkrehi 4988 9 well well RB cord-335975-m6lkrehi 4988 10 as as IN cord-335975-m6lkrehi 4988 11 the the DT cord-335975-m6lkrehi 4988 12 causes cause NNS cord-335975-m6lkrehi 4988 13 of of IN cord-335975-m6lkrehi 4988 14 ARF ARF NNP cord-335975-m6lkrehi 4988 15 was be VBD cord-335975-m6lkrehi 4988 16 determined determine VBN cord-335975-m6lkrehi 4988 17 by by IN cord-335975-m6lkrehi 4988 18 three three CD cord-335975-m6lkrehi 4988 19 experienced experienced JJ cord-335975-m6lkrehi 4988 20 respiratory respiratory JJ cord-335975-m6lkrehi 4988 21 physicians physician NNS cord-335975-m6lkrehi 4988 22 and and CC cord-335975-m6lkrehi 4988 23 were be VBD cord-335975-m6lkrehi 4988 24 required require VBN cord-335975-m6lkrehi 4988 25 for for IN cord-335975-m6lkrehi 4988 26 inclusion inclusion NN cord-335975-m6lkrehi 4988 27 : : : cord-335975-m6lkrehi 4988 28 a a DT cord-335975-m6lkrehi 4988 29 respiratory respiratory JJ cord-335975-m6lkrehi 4988 30 rate rate NN cord-335975-m6lkrehi 4988 31 > > XX cord-335975-m6lkrehi 4988 32 20 20 CD cord-335975-m6lkrehi 4988 33 cycles cycle NNS cord-335975-m6lkrehi 4988 34 / / SYM cord-335975-m6lkrehi 4988 35 min min NN cord-335975-m6lkrehi 4988 36 and and CC cord-335975-m6lkrehi 4988 37 a a DT cord-335975-m6lkrehi 4988 38 PaO2 PaO2 NNS cord-335975-m6lkrehi 4988 39 / / SYM cord-335975-m6lkrehi 4988 40 FiO fio NN cord-335975-m6lkrehi 4988 41 2 2 CD cord-335975-m6lkrehi 4988 42 < < XX cord-335975-m6lkrehi 4988 43 300 300 CD cord-335975-m6lkrehi 4988 44 for for IN cord-335975-m6lkrehi 4988 45 patients patient NNS cord-335975-m6lkrehi 4988 46 in in IN cord-335975-m6lkrehi 4988 47 spontaneous spontaneous JJ cord-335975-m6lkrehi 4988 48 breathing breathing NN cord-335975-m6lkrehi 4988 49 and and CC cord-335975-m6lkrehi 4988 50 only only RB cord-335975-m6lkrehi 4988 51 a a DT cord-335975-m6lkrehi 4988 52 PaO2 PaO2 NNS cord-335975-m6lkrehi 4988 53 / / SYM cord-335975-m6lkrehi 4988 54 FiO fio NN cord-335975-m6lkrehi 4988 55 2 2 CD cord-335975-m6lkrehi 4988 56 < < XX cord-335975-m6lkrehi 4988 57 300 300 CD cord-335975-m6lkrehi 4988 58 for for IN cord-335975-m6lkrehi 4988 59 patients patient NNS cord-335975-m6lkrehi 4988 60 under under IN cord-335975-m6lkrehi 4988 61 mechanical mechanical JJ cord-335975-m6lkrehi 4988 62 ventilation ventilation NN cord-335975-m6lkrehi 4988 63 . . . cord-335975-m6lkrehi 4989 1 In in IN cord-335975-m6lkrehi 4989 2 both both DT cord-335975-m6lkrehi 4989 3 groups group NNS cord-335975-m6lkrehi 4989 4 were be VBD cord-335975-m6lkrehi 4989 5 excluded exclude VBN cord-335975-m6lkrehi 4989 6 patients patient NNS cord-335975-m6lkrehi 4989 7 with with IN cord-335975-m6lkrehi 4989 8 metastatic metastatic JJ cord-335975-m6lkrehi 4989 9 solid solid JJ cord-335975-m6lkrehi 4989 10 tumors tumor NNS cord-335975-m6lkrehi 4989 11 , , , cord-335975-m6lkrehi 4989 12 benign benign JJ cord-335975-m6lkrehi 4989 13 tumors tumor NNS cord-335975-m6lkrehi 4989 14 or or CC cord-335975-m6lkrehi 4989 15 tumors tumor NNS cord-335975-m6lkrehi 4989 16 with with IN cord-335975-m6lkrehi 4989 17 more more JJR cord-335975-m6lkrehi 4989 18 than than IN cord-335975-m6lkrehi 4989 19 5 5 CD cord-335975-m6lkrehi 4989 20 years year NNS cord-335975-m6lkrehi 4989 21 of of IN cord-335975-m6lkrehi 4989 22 complete complete JJ cord-335975-m6lkrehi 4989 23 remission remission NN cord-335975-m6lkrehi 4989 24 , , , cord-335975-m6lkrehi 4989 25 recent recent JJ cord-335975-m6lkrehi 4989 26 post post JJ cord-335975-m6lkrehi 4989 27 - - JJ cord-335975-m6lkrehi 4989 28 operative operative JJ cord-335975-m6lkrehi 4989 29 patients patient NNS cord-335975-m6lkrehi 4989 30 , , , cord-335975-m6lkrehi 4989 31 and and CC cord-335975-m6lkrehi 4989 32 patients patient NNS cord-335975-m6lkrehi 4989 33 with with IN cord-335975-m6lkrehi 4989 34 other other JJ cord-335975-m6lkrehi 4989 35 immunodeficiency immunodeficiency NN cord-335975-m6lkrehi 4989 36 . . . cord-335975-m6lkrehi 4990 1 Results result NNS cord-335975-m6lkrehi 4990 2 : : : cord-335975-m6lkrehi 4991 1 A a DT cord-335975-m6lkrehi 4991 2 total total NN cord-335975-m6lkrehi 4991 3 of of IN cord-335975-m6lkrehi 4991 4 84 84 CD cord-335975-m6lkrehi 4991 5 cases case NNS cord-335975-m6lkrehi 4991 6 and and CC cord-335975-m6lkrehi 4991 7 133 133 CD cord-335975-m6lkrehi 4991 8 controls control NNS cord-335975-m6lkrehi 4991 9 were be VBD cord-335975-m6lkrehi 4991 10 included include VBN cord-335975-m6lkrehi 4991 11 . . . cord-335975-m6lkrehi 4992 1 Main main JJ cord-335975-m6lkrehi 4992 2 patients patient NNS cord-335975-m6lkrehi 4992 3 ' ' POS cord-335975-m6lkrehi 4992 4 characteristics characteristic NNS cord-335975-m6lkrehi 4992 5 are be VBP cord-335975-m6lkrehi 4992 6 reported report VBN cord-335975-m6lkrehi 4992 7 in in IN cord-335975-m6lkrehi 4992 8 the the DT cord-335975-m6lkrehi 4992 9 Table Table NNP cord-335975-m6lkrehi 4992 10 1 1 CD cord-335975-m6lkrehi 4992 11 . . . cord-335975-m6lkrehi 4993 1 Acute acute JJ cord-335975-m6lkrehi 4993 2 infectious infectious JJ cord-335975-m6lkrehi 4993 3 pneumonia pneumonia NN cord-335975-m6lkrehi 4993 4 was be VBD cord-335975-m6lkrehi 4993 5 the the DT cord-335975-m6lkrehi 4993 6 leading leading JJ cord-335975-m6lkrehi 4993 7 cause cause NN cord-335975-m6lkrehi 4993 8 of of IN cord-335975-m6lkrehi 4993 9 ARF arf NN cord-335975-m6lkrehi 4993 10 in in IN cord-335975-m6lkrehi 4993 11 both both DT cord-335975-m6lkrehi 4993 12 groups group NNS cord-335975-m6lkrehi 4993 13 but but CC cord-335975-m6lkrehi 4993 14 was be VBD cord-335975-m6lkrehi 4993 15 more more RBR cord-335975-m6lkrehi 4993 16 frequent frequent JJ cord-335975-m6lkrehi 4993 17 among among IN cord-335975-m6lkrehi 4993 18 cases case NNS cord-335975-m6lkrehi 4993 19 ( ( -LRB- cord-335975-m6lkrehi 4993 20 77 77 CD cord-335975-m6lkrehi 4993 21 vs. vs. CC cord-335975-m6lkrehi 4993 22 36 36 CD cord-335975-m6lkrehi 4993 23 % % NN cord-335975-m6lkrehi 4993 24 , , , cord-335975-m6lkrehi 4993 25 p p NN cord-335975-m6lkrehi 4993 26 < < XX cord-335975-m6lkrehi 4993 27 0.001 0.001 CD cord-335975-m6lkrehi 4993 28 ) ) -RRB- cord-335975-m6lkrehi 4993 29 . . . cord-335975-m6lkrehi 4994 1 Cardiogenic cardiogenic JJ cord-335975-m6lkrehi 4994 2 pulmonary pulmonary JJ cord-335975-m6lkrehi 4994 3 edema edema NN cord-335975-m6lkrehi 4994 4 and and CC cord-335975-m6lkrehi 4994 5 exacerbation exacerbation NN cord-335975-m6lkrehi 4994 6 of of IN cord-335975-m6lkrehi 4994 7 chronic chronic JJ cord-335975-m6lkrehi 4994 8 respiratory respiratory JJ cord-335975-m6lkrehi 4994 9 diseases disease NNS cord-335975-m6lkrehi 4994 10 were be VBD cord-335975-m6lkrehi 4994 11 more more JJR cord-335975-m6lkrehi 4994 12 frequents frequent NNS cord-335975-m6lkrehi 4994 13 in in IN cord-335975-m6lkrehi 4994 14 controls control NNS cord-335975-m6lkrehi 4994 15 ( ( -LRB- cord-335975-m6lkrehi 4994 16 10 10 CD cord-335975-m6lkrehi 4994 17 vs. vs. NN cord-335975-m6lkrehi 4994 18 37 37 CD cord-335975-m6lkrehi 4994 19 % % NN cord-335975-m6lkrehi 4994 20 , , , cord-335975-m6lkrehi 4994 21 p p NN cord-335975-m6lkrehi 4994 22 < < XX cord-335975-m6lkrehi 4994 23 0.001 0.001 CD cord-335975-m6lkrehi 4994 24 ) ) -RRB- cord-335975-m6lkrehi 4994 25 . . . cord-335975-m6lkrehi 4995 1 Pulmonary pulmonary JJ cord-335975-m6lkrehi 4995 2 embolism embolism NN cord-335975-m6lkrehi 4995 3 was be VBD cord-335975-m6lkrehi 4995 4 similar similar JJ cord-335975-m6lkrehi 4995 5 between between IN cord-335975-m6lkrehi 4995 6 the the DT cord-335975-m6lkrehi 4995 7 two two CD cord-335975-m6lkrehi 4995 8 groups group NNS cord-335975-m6lkrehi 4995 9 ( ( -LRB- cord-335975-m6lkrehi 4995 10 10 10 CD cord-335975-m6lkrehi 4995 11 vs. vs. NN cord-335975-m6lkrehi 4995 12 4 4 CD cord-335975-m6lkrehi 4995 13 % % NN cord-335975-m6lkrehi 4995 14 , , , cord-335975-m6lkrehi 4995 15 p p NN cord-335975-m6lkrehi 4995 16 = = SYM cord-335975-m6lkrehi 4995 17 0.143 0.143 CD cord-335975-m6lkrehi 4995 18 ) ) -RRB- cord-335975-m6lkrehi 4995 19 . . . cord-335975-m6lkrehi 4996 1 Among among IN cord-335975-m6lkrehi 4996 2 acute acute JJ cord-335975-m6lkrehi 4996 3 infectious infectious JJ cord-335975-m6lkrehi 4996 4 pneumonia pneumonia NN cord-335975-m6lkrehi 4996 5 , , , cord-335975-m6lkrehi 4996 6 pneumocystis pneumocystis NN cord-335975-m6lkrehi 4996 7 pneumonia pneumonia NN cord-335975-m6lkrehi 4996 8 ( ( -LRB- cord-335975-m6lkrehi 4996 9 PCP PCP NNP cord-335975-m6lkrehi 4996 10 ) ) -RRB- cord-335975-m6lkrehi 4996 11 and and CC cord-335975-m6lkrehi 4996 12 aspiration aspiration NN cord-335975-m6lkrehi 4996 13 pneumonia pneumonia NN cord-335975-m6lkrehi 4996 14 were be VBD cord-335975-m6lkrehi 4996 15 more more RBR cord-335975-m6lkrehi 4996 16 frequent frequent JJ cord-335975-m6lkrehi 4996 17 in in IN cord-335975-m6lkrehi 4996 18 cases case NNS cord-335975-m6lkrehi 4996 19 ( ( -LRB- cord-335975-m6lkrehi 4996 20 19 19 CD cord-335975-m6lkrehi 4996 21 vs. vs. CC cord-335975-m6lkrehi 4996 22 2 2 CD cord-335975-m6lkrehi 4996 23 % % NN cord-335975-m6lkrehi 4996 24 , , , cord-335975-m6lkrehi 4996 25 p p NN cord-335975-m6lkrehi 4996 26 < < XX cord-335975-m6lkrehi 4996 27 0.001 0.001 CD cord-335975-m6lkrehi 4996 28 and and CC cord-335975-m6lkrehi 4996 29 19 19 CD cord-335975-m6lkrehi 4996 30 vs. vs. CC cord-335975-m6lkrehi 4996 31 8 8 CD cord-335975-m6lkrehi 4996 32 % % NN cord-335975-m6lkrehi 4996 33 , , , cord-335975-m6lkrehi 4996 34 p p NN cord-335975-m6lkrehi 4996 35 < < XX cord-335975-m6lkrehi 4996 36 0.001 0.001 CD cord-335975-m6lkrehi 4996 37 respectively respectively RB cord-335975-m6lkrehi 4996 38 ) ) -RRB- cord-335975-m6lkrehi 4996 39 . . . cord-335975-m6lkrehi 4997 1 In in IN cord-335975-m6lkrehi 4997 2 multivariate multivariate JJ cord-335975-m6lkrehi 4997 3 analysis analysis NN cord-335975-m6lkrehi 4997 4 cancer cancer NN cord-335975-m6lkrehi 4997 5 progression progression NN cord-335975-m6lkrehi 4997 6 ( ( -LRB- cord-335975-m6lkrehi 4997 7 OR-7.25 or-7.25 NN cord-335975-m6lkrehi 4998 1 95%IC 95%ic CD cord-335975-m6lkrehi 4998 2 [ [ -LRB- cord-335975-m6lkrehi 4998 3 1.13 1.13 CD cord-335975-m6lkrehi 4998 4 - - SYM cord-335975-m6lkrehi 4998 5 46 46 CD cord-335975-m6lkrehi 4998 6 .45 .45 CD cord-335975-m6lkrehi 4998 7 ] ] -RRB- cord-335975-m6lkrehi 4998 8 , , , cord-335975-m6lkrehi 4998 9 p p NN cord-335975-m6lkrehi 4998 10 = = SYM cord-335975-m6lkrehi 4998 11 0.034 0.034 CD cord-335975-m6lkrehi 4998 12 ) ) -RRB- cord-335975-m6lkrehi 4998 13 , , , cord-335975-m6lkrehi 4998 14 need need VBP cord-335975-m6lkrehi 4998 15 for for IN cord-335975-m6lkrehi 4998 16 intubation intubation NN cord-335975-m6lkrehi 4998 17 ( ( -LRB- cord-335975-m6lkrehi 4998 18 OR-7.01 OR-7.01 NNP cord-335975-m6lkrehi 4998 19 95%IC 95%ic CD cord-335975-m6lkrehi 4999 1 [ [ -LRB- cord-335975-m6lkrehi 4999 2 1.29 1.29 CD cord-335975-m6lkrehi 4999 3 - - SYM cord-335975-m6lkrehi 4999 4 38 38 CD cord-335975-m6lkrehi 4999 5 .54 .54 CD cord-335975-m6lkrehi 4999 6 ] ] -RRB- cord-335975-m6lkrehi 4999 7 , , , cord-335975-m6lkrehi 4999 8 p p NN cord-335975-m6lkrehi 4999 9 = = SYM cord-335975-m6lkrehi 4999 10 0.022 0.022 CD cord-335975-m6lkrehi 4999 11 ) ) -RRB- cord-335975-m6lkrehi 4999 12 and and CC cord-335975-m6lkrehi 4999 13 respiratory respiratory JJ cord-335975-m6lkrehi 4999 14 rate rate NN cord-335975-m6lkrehi 4999 15 ( ( -LRB- cord-335975-m6lkrehi 4999 16 OR-1.17 OR-1.17 NNP cord-335975-m6lkrehi 4999 17 95 95 CD cord-335975-m6lkrehi 4999 18 % % NN cord-335975-m6lkrehi 4999 19 CI CI NNP cord-335975-m6lkrehi 4999 20 [ [ -LRB- cord-335975-m6lkrehi 4999 21 1.05 1.05 CD cord-335975-m6lkrehi 4999 22 - - SYM cord-335975-m6lkrehi 4999 23 1.30 1.30 CD cord-335975-m6lkrehi 4999 24 ] ] -RRB- cord-335975-m6lkrehi 5000 1 , , , cord-335975-m6lkrehi 5000 2 p p NN cord-335975-m6lkrehi 5000 3 = = SYM cord-335975-m6lkrehi 5000 4 0.003 0.003 CD cord-335975-m6lkrehi 5000 5 ) ) -RRB- cord-335975-m6lkrehi 5000 6 independently independently RB cord-335975-m6lkrehi 5000 7 predicted predict VBD cord-335975-m6lkrehi 5000 8 ICU ICU NNP cord-335975-m6lkrehi 5000 9 mortality mortality NN cord-335975-m6lkrehi 5000 10 of of IN cord-335975-m6lkrehi 5000 11 PMBT PMBT NNP cord-335975-m6lkrehi 5000 12 patients patient NNS cord-335975-m6lkrehi 5000 13 . . . cord-335975-m6lkrehi 5001 1 Conclusion conclusion NN cord-335975-m6lkrehi 5001 2 : : : cord-335975-m6lkrehi 5002 1 In in IN cord-335975-m6lkrehi 5002 2 PMBT PMBT NNP cord-335975-m6lkrehi 5002 3 patients patient NNS cord-335975-m6lkrehi 5002 4 , , , cord-335975-m6lkrehi 5002 5 the the DT cord-335975-m6lkrehi 5002 6 causes cause NNS cord-335975-m6lkrehi 5002 7 of of IN cord-335975-m6lkrehi 5002 8 ARF ARF NNP cord-335975-m6lkrehi 5002 9 differ differ VBP cord-335975-m6lkrehi 5002 10 significantly significantly RB cord-335975-m6lkrehi 5002 11 from from IN cord-335975-m6lkrehi 5002 12 other other JJ cord-335975-m6lkrehi 5002 13 cancer cancer NN cord-335975-m6lkrehi 5002 14 patients patient NNS cord-335975-m6lkrehi 5002 15 . . . cord-335975-m6lkrehi 5003 1 Up up IN cord-335975-m6lkrehi 5003 2 to to TO cord-335975-m6lkrehi 5003 3 30 30 CD cord-335975-m6lkrehi 5003 4 % % NN cord-335975-m6lkrehi 5003 5 of of IN cord-335975-m6lkrehi 5003 6 the the DT cord-335975-m6lkrehi 5003 7 admissions admission NNS cord-335975-m6lkrehi 5003 8 was be VBD cord-335975-m6lkrehi 5003 9 related relate VBN cord-335975-m6lkrehi 5003 10 to to IN cord-335975-m6lkrehi 5003 11 preventable preventable JJ cord-335975-m6lkrehi 5003 12 causes cause NNS cord-335975-m6lkrehi 5003 13 ( ( -LRB- cord-335975-m6lkrehi 5004 1 pulmonary pulmonary JJ cord-335975-m6lkrehi 5004 2 embolism embolism NN cord-335975-m6lkrehi 5004 3 , , , cord-335975-m6lkrehi 5004 4 PCP PCP NNP cord-335975-m6lkrehi 5004 5 ) ) -RRB- cord-335975-m6lkrehi 5004 6 and and CC cord-335975-m6lkrehi 5004 7 a a DT cord-335975-m6lkrehi 5004 8 curable curable JJ cord-335975-m6lkrehi 5004 9 cause cause NN cord-335975-m6lkrehi 5004 10 was be VBD cord-335975-m6lkrehi 5004 11 identified identify VBN cord-335975-m6lkrehi 5004 12 in in IN cord-335975-m6lkrehi 5004 13 the the DT cord-335975-m6lkrehi 5004 14 majority majority NN cord-335975-m6lkrehi 5004 15 of of IN cord-335975-m6lkrehi 5004 16 cases case NNS cord-335975-m6lkrehi 5004 17 . . . cord-335975-m6lkrehi 5005 1 Our -PRON- PRP$ cord-335975-m6lkrehi 5005 2 results result NNS cord-335975-m6lkrehi 5005 3 suggest suggest VBP cord-335975-m6lkrehi 5005 4 that that IN cord-335975-m6lkrehi 5005 5 PMBT PMBT NNP cord-335975-m6lkrehi 5005 6 alone alone RB cord-335975-m6lkrehi 5005 7 is be VBZ cord-335975-m6lkrehi 5005 8 not not RB cord-335975-m6lkrehi 5005 9 a a DT cord-335975-m6lkrehi 5005 10 relevant relevant JJ cord-335975-m6lkrehi 5005 11 criterion criterion NN cord-335975-m6lkrehi 5005 12 for for IN cord-335975-m6lkrehi 5005 13 ICU ICU NNP cord-335975-m6lkrehi 5005 14 recusal recusal NN cord-335975-m6lkrehi 5005 15 . . . cord-335975-m6lkrehi 5006 1 Introduction introduction NN cord-335975-m6lkrehi 5006 2 : : : cord-335975-m6lkrehi 5007 1 Drug drug NN cord-335975-m6lkrehi 5007 2 intoxication intoxication NN cord-335975-m6lkrehi 5007 3 is be VBZ cord-335975-m6lkrehi 5007 4 a a DT cord-335975-m6lkrehi 5007 5 common common JJ cord-335975-m6lkrehi 5007 6 problem problem NN cord-335975-m6lkrehi 5007 7 encountered encounter VBN cord-335975-m6lkrehi 5007 8 in in IN cord-335975-m6lkrehi 5007 9 emergency emergency NN cord-335975-m6lkrehi 5007 10 departments department NNS cord-335975-m6lkrehi 5007 11 . . . cord-335975-m6lkrehi 5008 1 Poisoning poisoning NN cord-335975-m6lkrehi 5008 2 remains remain VBZ cord-335975-m6lkrehi 5008 3 a a DT cord-335975-m6lkrehi 5008 4 major major JJ cord-335975-m6lkrehi 5008 5 cause cause NN cord-335975-m6lkrehi 5008 6 of of IN cord-335975-m6lkrehi 5008 7 hospitalization hospitalization NN cord-335975-m6lkrehi 5008 8 for for IN cord-335975-m6lkrehi 5008 9 young young JJ cord-335975-m6lkrehi 5008 10 people people NNS cord-335975-m6lkrehi 5008 11 , , , cord-335975-m6lkrehi 5008 12 and and CC cord-335975-m6lkrehi 5008 13 that that DT cord-335975-m6lkrehi 5008 14 of of IN cord-335975-m6lkrehi 5008 15 the the DT cord-335975-m6lkrehi 5008 16 elderly elderly JJ cord-335975-m6lkrehi 5008 17 is be VBZ cord-335975-m6lkrehi 5008 18 constantly constantly RB cord-335975-m6lkrehi 5008 19 increasing increase VBG cord-335975-m6lkrehi 5008 20 . . . cord-335975-m6lkrehi 5009 1 Objectives objective NNS cord-335975-m6lkrehi 5009 2 1 1 CD cord-335975-m6lkrehi 5009 3 . . . cord-335975-m6lkrehi 5010 1 Determine determine VB cord-335975-m6lkrehi 5010 2 the the DT cord-335975-m6lkrehi 5010 3 epidemiological epidemiological JJ cord-335975-m6lkrehi 5010 4 characteristics characteristic NNS cord-335975-m6lkrehi 5010 5 of of IN cord-335975-m6lkrehi 5010 6 addicted addicted JJ cord-335975-m6lkrehi 5010 7 patients patient NNS cord-335975-m6lkrehi 5010 8 2 2 CD cord-335975-m6lkrehi 5010 9 . . . cord-335975-m6lkrehi 5011 1 Know know VB cord-335975-m6lkrehi 5011 2 the the DT cord-335975-m6lkrehi 5011 3 clinical clinical JJ cord-335975-m6lkrehi 5011 4 manifestations manifestation NNS cord-335975-m6lkrehi 5011 5 of of IN cord-335975-m6lkrehi 5011 6 poisoning poisoning NN cord-335975-m6lkrehi 5011 7 . . . cord-335975-m6lkrehi 5012 1 Patients patient NNS cord-335975-m6lkrehi 5012 2 and and CC cord-335975-m6lkrehi 5012 3 methods method NNS cord-335975-m6lkrehi 5012 4 : : : cord-335975-m6lkrehi 5012 5 A a DT cord-335975-m6lkrehi 5012 6 retrospective retrospective JJ cord-335975-m6lkrehi 5012 7 study study NN cord-335975-m6lkrehi 5012 8 of of IN cord-335975-m6lkrehi 5012 9 cases case NNS cord-335975-m6lkrehi 5012 10 of of IN cord-335975-m6lkrehi 5012 11 acute acute JJ cord-335975-m6lkrehi 5012 12 poisoning poisoning NN cord-335975-m6lkrehi 5012 13 recorded record VBN cord-335975-m6lkrehi 5012 14 at at IN cord-335975-m6lkrehi 5012 15 the the DT cord-335975-m6lkrehi 5012 16 University University NNP cord-335975-m6lkrehi 5012 17 Hospital Hospital NNP cord-335975-m6lkrehi 5012 18 Center Center NNP cord-335975-m6lkrehi 5012 19 CHUOran chuoran NN cord-335975-m6lkrehi 5012 20 between between IN cord-335975-m6lkrehi 5012 21 January January NNP cord-335975-m6lkrehi 5012 22 2013 2013 CD cord-335975-m6lkrehi 5012 23 and and CC cord-335975-m6lkrehi 5012 24 December December NNP cord-335975-m6lkrehi 5012 25 2015 2015 CD cord-335975-m6lkrehi 5012 26 was be VBD cord-335975-m6lkrehi 5012 27 carried carry VBN cord-335975-m6lkrehi 5012 28 out out RP cord-335975-m6lkrehi 5012 29 . . . cord-335975-m6lkrehi 5013 1 Seizure seizure NN cord-335975-m6lkrehi 5013 2 on on IN cord-335975-m6lkrehi 5013 3 data datum NNS cord-335975-m6lkrehi 5013 4 processing processing NN cord-335975-m6lkrehi 5013 5 by by IN cord-335975-m6lkrehi 5013 6 epi epi NNP cord-335975-m6lkrehi 5013 7 - - HYPH cord-335975-m6lkrehi 5013 8 info info NN cord-335975-m6lkrehi 5013 9 version version NN cord-335975-m6lkrehi 5013 10 3.5 3.5 CD cord-335975-m6lkrehi 5013 11 Results result NNS cord-335975-m6lkrehi 5013 12 : : : cord-335975-m6lkrehi 5013 13 808 808 CD cord-335975-m6lkrehi 5013 14 cases case NNS cord-335975-m6lkrehi 5013 15 of of IN cord-335975-m6lkrehi 5013 16 acute acute JJ cord-335975-m6lkrehi 5013 17 poisoning poisoning NN cord-335975-m6lkrehi 5013 18 , , , cord-335975-m6lkrehi 5013 19 with with IN cord-335975-m6lkrehi 5013 20 an an DT cord-335975-m6lkrehi 5013 21 age age NN cord-335975-m6lkrehi 5013 22 ranging range VBG cord-335975-m6lkrehi 5013 23 from from IN cord-335975-m6lkrehi 5013 24 16 16 CD cord-335975-m6lkrehi 5013 25 to to TO cord-335975-m6lkrehi 5013 26 90 90 CD cord-335975-m6lkrehi 5013 27 years year NNS cord-335975-m6lkrehi 5013 28 . . . cord-335975-m6lkrehi 5014 1 Female female JJ cord-335975-m6lkrehi 5014 2 patients patient NNS cord-335975-m6lkrehi 5014 3 predominated predominate VBD cord-335975-m6lkrehi 5014 4 with with IN cord-335975-m6lkrehi 5014 5 67 67 CD cord-335975-m6lkrehi 5014 6 % % NN cord-335975-m6lkrehi 5014 7 . . . cord-335975-m6lkrehi 5015 1 People People NNS cord-335975-m6lkrehi 5015 2 between between IN cord-335975-m6lkrehi 5015 3 the the DT cord-335975-m6lkrehi 5015 4 ages age NNS cord-335975-m6lkrehi 5015 5 of of IN cord-335975-m6lkrehi 5015 6 16 16 CD cord-335975-m6lkrehi 5015 7 and and CC cord-335975-m6lkrehi 5015 8 25 25 CD cord-335975-m6lkrehi 5015 9 are be VBP cord-335975-m6lkrehi 5015 10 the the DT cord-335975-m6lkrehi 5015 11 people people NNS cord-335975-m6lkrehi 5015 12 most most RBS cord-335975-m6lkrehi 5015 13 affected affect VBN cord-335975-m6lkrehi 5015 14 by by IN cord-335975-m6lkrehi 5015 15 poisoning poisoning NN cord-335975-m6lkrehi 5015 16 . . . cord-335975-m6lkrehi 5016 1 The the DT cord-335975-m6lkrehi 5016 2 nature nature NN cord-335975-m6lkrehi 5016 3 of of IN cord-335975-m6lkrehi 5016 4 poisoning poisoning NN cord-335975-m6lkrehi 5016 5 is be VBZ cord-335975-m6lkrehi 5016 6 varied varied JJ cord-335975-m6lkrehi 5016 7 . . . cord-335975-m6lkrehi 5017 1 In in IN cord-335975-m6lkrehi 5017 2 this this DT cord-335975-m6lkrehi 5017 3 series series NN cord-335975-m6lkrehi 5017 4 , , , cord-335975-m6lkrehi 5017 5 analgesics analgesic NNS cord-335975-m6lkrehi 5017 6 were be VBD cord-335975-m6lkrehi 5017 7 found find VBN cord-335975-m6lkrehi 5017 8 to to TO cord-335975-m6lkrehi 5017 9 be be VB cord-335975-m6lkrehi 5017 10 the the DT cord-335975-m6lkrehi 5017 11 leading leading JJ cord-335975-m6lkrehi 5017 12 cause cause NN cord-335975-m6lkrehi 5017 13 of of IN cord-335975-m6lkrehi 5017 14 acute acute JJ cord-335975-m6lkrehi 5017 15 intoxication intoxication NN cord-335975-m6lkrehi 5017 16 , , , cord-335975-m6lkrehi 5017 17 with with IN cord-335975-m6lkrehi 5017 18 81 81 CD cord-335975-m6lkrehi 5017 19 cases case NNS cord-335975-m6lkrehi 5017 20 , , , cord-335975-m6lkrehi 5017 21 31 31 CD cord-335975-m6lkrehi 5017 22 % % NN cord-335975-m6lkrehi 5017 23 followed follow VBN cord-335975-m6lkrehi 5017 24 by by IN cord-335975-m6lkrehi 5017 25 psychotropic psychotropic JJ cord-335975-m6lkrehi 5017 26 drugs drug NNS cord-335975-m6lkrehi 5017 27 ( ( -LRB- cord-335975-m6lkrehi 5017 28 24 24 CD cord-335975-m6lkrehi 5017 29 % % NN cord-335975-m6lkrehi 5017 30 ) ) -RRB- cord-335975-m6lkrehi 5017 31 , , , cord-335975-m6lkrehi 5017 32 benzodiazepines benzodiazepine NNS cord-335975-m6lkrehi 5017 33 ( ( -LRB- cord-335975-m6lkrehi 5017 34 21 21 CD cord-335975-m6lkrehi 5017 35 % % NN cord-335975-m6lkrehi 5017 36 ) ) -RRB- cord-335975-m6lkrehi 5017 37 , , , cord-335975-m6lkrehi 5017 38 neuroleptics neuroleptic NNS cord-335975-m6lkrehi 5017 39 ( ( -LRB- cord-335975-m6lkrehi 5017 40 6 6 CD cord-335975-m6lkrehi 5017 41 % % NN cord-335975-m6lkrehi 5017 42 ) ) -RRB- cord-335975-m6lkrehi 5017 43 , , , cord-335975-m6lkrehi 5017 44 antiepileptics% antiepileptics% NNP cord-335975-m6lkrehi 5017 45 ) ) -RRB- cord-335975-m6lkrehi 5017 46 and and CC cord-335975-m6lkrehi 5017 47 antihistamines antihistamine NNS cord-335975-m6lkrehi 5017 48 ( ( -LRB- cord-335975-m6lkrehi 5017 49 9 9 CD cord-335975-m6lkrehi 5017 50 % % NN cord-335975-m6lkrehi 5017 51 ) ) -RRB- cord-335975-m6lkrehi 5017 52 . . . cord-335975-m6lkrehi 5018 1 The the DT cord-335975-m6lkrehi 5018 2 majority majority NN cord-335975-m6lkrehi 5018 3 of of IN cord-335975-m6lkrehi 5018 4 acute acute JJ cord-335975-m6lkrehi 5018 5 intoxications intoxication NNS cord-335975-m6lkrehi 5018 6 were be VBD cord-335975-m6lkrehi 5018 7 managed manage VBN cord-335975-m6lkrehi 5018 8 within within IN cord-335975-m6lkrehi 5018 9 an an DT cord-335975-m6lkrehi 5018 10 average average JJ cord-335975-m6lkrehi 5018 11 time time NN cord-335975-m6lkrehi 5018 12 of of IN cord-335975-m6lkrehi 5018 13 2.51 2.51 CD cord-335975-m6lkrehi 5018 14 ± ± CD cord-335975-m6lkrehi 5018 15 3.03 3.03 CD cord-335975-m6lkrehi 5018 16 h h NN cord-335975-m6lkrehi 5018 17 with with IN cord-335975-m6lkrehi 5018 18 an an DT cord-335975-m6lkrehi 5018 19 interval interval NN cord-335975-m6lkrehi 5018 20 between between IN cord-335975-m6lkrehi 5018 21 0.5 0.5 CD cord-335975-m6lkrehi 5018 22 and and CC cord-335975-m6lkrehi 5018 23 48 48 CD cord-335975-m6lkrehi 5018 24 h. h. NN cord-335975-m6lkrehi 5019 1 In in IN cord-335975-m6lkrehi 5019 2 74 74 CD cord-335975-m6lkrehi 5019 3 % % NN cord-335975-m6lkrehi 5019 4 of of IN cord-335975-m6lkrehi 5019 5 cases case NNS cord-335975-m6lkrehi 5019 6 the the DT cord-335975-m6lkrehi 5019 7 poisoning poisoning NN cord-335975-m6lkrehi 5019 8 was be VBD cord-335975-m6lkrehi 5019 9 asymptomatic asymptomatic JJ cord-335975-m6lkrehi 5019 10 , , , cord-335975-m6lkrehi 5019 11 there there EX cord-335975-m6lkrehi 5019 12 were be VBD cord-335975-m6lkrehi 5019 13 digestive digestive JJ cord-335975-m6lkrehi 5019 14 manifestations manifestation NNS cord-335975-m6lkrehi 5019 15 in in IN cord-335975-m6lkrehi 5019 16 10 10 CD cord-335975-m6lkrehi 5019 17 % % NN cord-335975-m6lkrehi 5019 18 of of IN cord-335975-m6lkrehi 5019 19 patients patient NNS cord-335975-m6lkrehi 5019 20 , , , cord-335975-m6lkrehi 5019 21 7 7 CD cord-335975-m6lkrehi 5019 22 % % NN cord-335975-m6lkrehi 5019 23 Neurological Neurological NNP cord-335975-m6lkrehi 5019 24 , , , cord-335975-m6lkrehi 5019 25 6 6 CD cord-335975-m6lkrehi 5019 26 % % NN cord-335975-m6lkrehi 5019 27 Cardiovascular cardiovascular NN cord-335975-m6lkrehi 5019 28 and and CC cord-335975-m6lkrehi 5019 29 3 3 CD cord-335975-m6lkrehi 5019 30 % % NN cord-335975-m6lkrehi 5019 31 respiratory respiratory NN cord-335975-m6lkrehi 5019 32 . . . cord-335975-m6lkrehi 5020 1 We -PRON- PRP cord-335975-m6lkrehi 5020 2 deplore deplore VBP cord-335975-m6lkrehi 5020 3 1 1 CD cord-335975-m6lkrehi 5020 4 death death NN cord-335975-m6lkrehi 5020 5 in in IN cord-335975-m6lkrehi 5020 6 this this DT cord-335975-m6lkrehi 5020 7 series series NN cord-335975-m6lkrehi 5020 8 secondary secondary JJ cord-335975-m6lkrehi 5020 9 to to IN cord-335975-m6lkrehi 5020 10 many many JJ cord-335975-m6lkrehi 5020 11 drug drug NN cord-335975-m6lkrehi 5020 12 poisoning poisoning NN cord-335975-m6lkrehi 5020 13 . . . cord-335975-m6lkrehi 5021 1 Conclusion conclusion NN cord-335975-m6lkrehi 5021 2 : : : cord-335975-m6lkrehi 5022 1 Acute acute JJ cord-335975-m6lkrehi 5022 2 drug drug NN cord-335975-m6lkrehi 5022 3 poisoning poisoning NN cord-335975-m6lkrehi 5022 4 is be VBZ cord-335975-m6lkrehi 5022 5 a a DT cord-335975-m6lkrehi 5022 6 common common JJ cord-335975-m6lkrehi 5022 7 reason reason NN cord-335975-m6lkrehi 5022 8 for for IN cord-335975-m6lkrehi 5022 9 admission admission NN cord-335975-m6lkrehi 5022 10 to to IN cord-335975-m6lkrehi 5022 11 the the DT cord-335975-m6lkrehi 5022 12 emergency emergency NN cord-335975-m6lkrehi 5022 13 department department NN cord-335975-m6lkrehi 5022 14 of of IN cord-335975-m6lkrehi 5022 15 Oran Oran NNP cord-335975-m6lkrehi 5022 16 University University NNP cord-335975-m6lkrehi 5022 17 Hospital Hospital NNP cord-335975-m6lkrehi 5022 18 . . . cord-335975-m6lkrehi 5023 1 The the DT cord-335975-m6lkrehi 5023 2 large large JJ cord-335975-m6lkrehi 5023 3 number number NN cord-335975-m6lkrehi 5023 4 of of IN cord-335975-m6lkrehi 5023 5 drug drug NN cord-335975-m6lkrehi 5023 6 families family NNS cord-335975-m6lkrehi 5023 7 offered offer VBN cord-335975-m6lkrehi 5023 8 for for IN cord-335975-m6lkrehi 5023 9 sale sale NN cord-335975-m6lkrehi 5023 10 , , , cord-335975-m6lkrehi 5023 11 as as RB cord-335975-m6lkrehi 5023 12 well well RB cord-335975-m6lkrehi 5023 13 as as IN cord-335975-m6lkrehi 5023 14 the the DT cord-335975-m6lkrehi 5023 15 heterogeneity heterogeneity NN cord-335975-m6lkrehi 5023 16 Introduction introduction NN cord-335975-m6lkrehi 5023 17 : : : cord-335975-m6lkrehi 5023 18 Selective selective JJ cord-335975-m6lkrehi 5023 19 serotonin serotonin NN cord-335975-m6lkrehi 5023 20 reuptake reuptake NN cord-335975-m6lkrehi 5023 21 inhibitors inhibitor NNS cord-335975-m6lkrehi 5023 22 ( ( -LRB- cord-335975-m6lkrehi 5023 23 SSRIs ssri NNS cord-335975-m6lkrehi 5023 24 ) ) -RRB- cord-335975-m6lkrehi 5023 25 have have VBP cord-335975-m6lkrehi 5023 26 been be VBN cord-335975-m6lkrehi 5023 27 considered consider VBN cord-335975-m6lkrehi 5023 28 for for IN cord-335975-m6lkrehi 5023 29 their -PRON- PRP$ cord-335975-m6lkrehi 5023 30 low low JJ cord-335975-m6lkrehi 5023 31 toxicity toxicity NN cord-335975-m6lkrehi 5023 32 comparatively comparatively RB cord-335975-m6lkrehi 5023 33 to to IN cord-335975-m6lkrehi 5023 34 antidepressant antidepressant JJ cord-335975-m6lkrehi 5023 35 agents agent NNS cord-335975-m6lkrehi 5023 36 . . . cord-335975-m6lkrehi 5024 1 The the DT cord-335975-m6lkrehi 5024 2 present present JJ cord-335975-m6lkrehi 5024 3 study study NN cord-335975-m6lkrehi 5024 4 aims aim VBZ cord-335975-m6lkrehi 5024 5 to to TO cord-335975-m6lkrehi 5024 6 describe describe VB cord-335975-m6lkrehi 5024 7 clinical clinical JJ cord-335975-m6lkrehi 5024 8 features feature NNS cord-335975-m6lkrehi 5024 9 and and CC cord-335975-m6lkrehi 5024 10 prognosis prognosis NN cord-335975-m6lkrehi 5024 11 of of IN cord-335975-m6lkrehi 5024 12 poisoning poisoning NN cord-335975-m6lkrehi 5024 13 SSRIs ssri NNS cord-335975-m6lkrehi 5024 14 . . . cord-335975-m6lkrehi 5025 1 Patients patient NNS cord-335975-m6lkrehi 5025 2 and and CC cord-335975-m6lkrehi 5025 3 methods method NNS cord-335975-m6lkrehi 5025 4 : : : cord-335975-m6lkrehi 5025 5 A a DT cord-335975-m6lkrehi 5025 6 retrospective retrospective JJ cord-335975-m6lkrehi 5025 7 study study NN cord-335975-m6lkrehi 5025 8 of of IN cord-335975-m6lkrehi 5025 9 patients patient NNS cord-335975-m6lkrehi 5025 10 admitted admit VBN cord-335975-m6lkrehi 5025 11 to to IN cord-335975-m6lkrehi 5025 12 our -PRON- PRP$ cord-335975-m6lkrehi 5025 13 12-bed 12-bed CD cord-335975-m6lkrehi 5025 14 teaching teaching NN cord-335975-m6lkrehi 5025 15 ICU ICU NNP cord-335975-m6lkrehi 5025 16 for for IN cord-335975-m6lkrehi 5025 17 acute acute JJ cord-335975-m6lkrehi 5025 18 SSRIs ssri NNS cord-335975-m6lkrehi 5025 19 poisoning poisoning NN cord-335975-m6lkrehi 5025 20 over over IN cord-335975-m6lkrehi 5025 21 a a DT cord-335975-m6lkrehi 5025 22 period period NN cord-335975-m6lkrehi 5025 23 of of IN cord-335975-m6lkrehi 5025 24 8 8 CD cord-335975-m6lkrehi 5025 25 years year NNS cord-335975-m6lkrehi 5025 26 from from IN cord-335975-m6lkrehi 5025 27 January January NNP cord-335975-m6lkrehi 5025 28 2009 2009 CD cord-335975-m6lkrehi 5025 29 to to IN cord-335975-m6lkrehi 5025 30 December December NNP cord-335975-m6lkrehi 5025 31 2016 2016 CD cord-335975-m6lkrehi 5025 32 . . . cord-335975-m6lkrehi 5026 1 SSRIs ssri NNS cord-335975-m6lkrehi 5026 2 poisoning poisoning NN cord-335975-m6lkrehi 5026 3 was be VBD cord-335975-m6lkrehi 5026 4 retained retain VBN cord-335975-m6lkrehi 5026 5 on on IN cord-335975-m6lkrehi 5026 6 a a DT cord-335975-m6lkrehi 5026 7 history history NN cord-335975-m6lkrehi 5026 8 of of IN cord-335975-m6lkrehi 5026 9 over over IN cord-335975-m6lkrehi 5026 10 dose dose NN cord-335975-m6lkrehi 5026 11 ingestion ingestion NN cord-335975-m6lkrehi 5026 12 , , , cord-335975-m6lkrehi 5026 13 clinical clinical JJ cord-335975-m6lkrehi 5026 14 signs sign NNS cord-335975-m6lkrehi 5026 15 and and CC cord-335975-m6lkrehi 5026 16 positive positive JJ cord-335975-m6lkrehi 5026 17 urine urine NN cord-335975-m6lkrehi 5026 18 samples sample NNS cord-335975-m6lkrehi 5026 19 for for IN cord-335975-m6lkrehi 5026 20 SSRIs ssri NNS cord-335975-m6lkrehi 5026 21 . . . cord-335975-m6lkrehi 5027 1 Results result NNS cord-335975-m6lkrehi 5027 2 : : : cord-335975-m6lkrehi 5028 1 Thirty thirty CD cord-335975-m6lkrehi 5028 2 seven seven CD cord-335975-m6lkrehi 5028 3 patients patient NNS cord-335975-m6lkrehi 5028 4 were be VBD cord-335975-m6lkrehi 5028 5 collected collect VBN cord-335975-m6lkrehi 5028 6 , , , cord-335975-m6lkrehi 5028 7 the the DT cord-335975-m6lkrehi 5028 8 middle middle JJ cord-335975-m6lkrehi 5028 9 age age NN cord-335975-m6lkrehi 5028 10 was be VBD cord-335975-m6lkrehi 5028 11 32 32 CD cord-335975-m6lkrehi 5028 12 ± ± NNP cord-335975-m6lkrehi 5028 13 15 15 CD cord-335975-m6lkrehi 5028 14 years year NNS cord-335975-m6lkrehi 5028 15 with with IN cord-335975-m6lkrehi 5028 16 a a DT cord-335975-m6lkrehi 5028 17 female female JJ cord-335975-m6lkrehi 5028 18 predominance predominance NN cord-335975-m6lkrehi 5028 19 ( ( -LRB- cord-335975-m6lkrehi 5028 20 86.5 86.5 CD cord-335975-m6lkrehi 5028 21 % % NN cord-335975-m6lkrehi 5028 22 ) ) -RRB- cord-335975-m6lkrehi 5028 23 . . . cord-335975-m6lkrehi 5029 1 A a DT cord-335975-m6lkrehi 5029 2 psychiatric psychiatric JJ cord-335975-m6lkrehi 5029 3 history history NN cord-335975-m6lkrehi 5029 4 with with IN cord-335975-m6lkrehi 5029 5 depressive depressive JJ cord-335975-m6lkrehi 5029 6 syndrome syndrome NN cord-335975-m6lkrehi 5029 7 was be VBD cord-335975-m6lkrehi 5029 8 noted note VBN cord-335975-m6lkrehi 5029 9 in in IN cord-335975-m6lkrehi 5029 10 67.6 67.6 CD cord-335975-m6lkrehi 5029 11 % % NN cord-335975-m6lkrehi 5029 12 and and CC cord-335975-m6lkrehi 5029 13 a a DT cord-335975-m6lkrehi 5029 14 history history NN cord-335975-m6lkrehi 5029 15 of of IN cord-335975-m6lkrehi 5029 16 suicide suicide NN cord-335975-m6lkrehi 5029 17 in in IN cord-335975-m6lkrehi 5029 18 13.5 13.5 CD cord-335975-m6lkrehi 5029 19 % % NN cord-335975-m6lkrehi 5029 20 . . . cord-335975-m6lkrehi 5030 1 Paroxetine Paroxetine NNP cord-335975-m6lkrehi 5030 2 was be VBD cord-335975-m6lkrehi 5030 3 the the DT cord-335975-m6lkrehi 5030 4 main main JJ cord-335975-m6lkrehi 5030 5 invoked invoke VBN cord-335975-m6lkrehi 5030 6 drug drug NN cord-335975-m6lkrehi 5030 7 ( ( -LRB- cord-335975-m6lkrehi 5030 8 n n NN cord-335975-m6lkrehi 5030 9 = = SYM cord-335975-m6lkrehi 5030 10 20 20 CD cord-335975-m6lkrehi 5030 11 ) ) -RRB- cord-335975-m6lkrehi 5030 12 , , , cord-335975-m6lkrehi 5030 13 followed follow VBN cord-335975-m6lkrehi 5030 14 by by IN cord-335975-m6lkrehi 5030 15 sertaline sertaline NNP cord-335975-m6lkrehi 5030 16 ( ( -LRB- cord-335975-m6lkrehi 5030 17 n n NN cord-335975-m6lkrehi 5030 18 = = SYM cord-335975-m6lkrehi 5030 19 8) 8) NN cord-335975-m6lkrehi 5030 20 , , , cord-335975-m6lkrehi 5030 21 then then RB cord-335975-m6lkrehi 5030 22 fluoxetine fluoxetine NNP cord-335975-m6lkrehi 5030 23 ( ( -LRB- cord-335975-m6lkrehi 5030 24 n n NN cord-335975-m6lkrehi 5030 25 = = SYM cord-335975-m6lkrehi 5030 26 6 6 CD cord-335975-m6lkrehi 5030 27 ) ) -RRB- cord-335975-m6lkrehi 5030 28 , , , cord-335975-m6lkrehi 5030 29 venlafaxine venlafaxine FW cord-335975-m6lkrehi 5030 30 ( ( -LRB- cord-335975-m6lkrehi 5030 31 n n NN cord-335975-m6lkrehi 5030 32 = = SYM cord-335975-m6lkrehi 5030 33 1 1 CD cord-335975-m6lkrehi 5030 34 ) ) -RRB- cord-335975-m6lkrehi 5030 35 citalopram citalopram NNP cord-335975-m6lkrehi 5030 36 ( ( -LRB- cord-335975-m6lkrehi 5030 37 n n NN cord-335975-m6lkrehi 5030 38 = = SYM cord-335975-m6lkrehi 5030 39 1 1 CD cord-335975-m6lkrehi 5030 40 ) ) -RRB- cord-335975-m6lkrehi 5030 41 . . . cord-335975-m6lkrehi 5031 1 The the DT cord-335975-m6lkrehi 5031 2 mean mean NN cord-335975-m6lkrehi 5031 3 supposed suppose VBD cord-335975-m6lkrehi 5031 4 ingestion ingestion NN cord-335975-m6lkrehi 5031 5 dose dose NN cord-335975-m6lkrehi 5031 6 was be VBD cord-335975-m6lkrehi 5031 7 342.9 342.9 CD cord-335975-m6lkrehi 5031 8 mg mg NN cord-335975-m6lkrehi 5031 9 . . . cord-335975-m6lkrehi 5032 1 Intoxication intoxication NN cord-335975-m6lkrehi 5032 2 was be VBD cord-335975-m6lkrehi 5032 3 pure pure JJ cord-335975-m6lkrehi 5032 4 in in IN cord-335975-m6lkrehi 5032 5 13 13 CD cord-335975-m6lkrehi 5032 6 cases case NNS cord-335975-m6lkrehi 5032 7 and and CC cord-335975-m6lkrehi 5032 8 associated associate VBN cord-335975-m6lkrehi 5032 9 with with IN cord-335975-m6lkrehi 5032 10 other other JJ cord-335975-m6lkrehi 5032 11 drugs drug NNS cord-335975-m6lkrehi 5032 12 in in IN cord-335975-m6lkrehi 5032 13 24 24 CD cord-335975-m6lkrehi 5032 14 cases case NNS cord-335975-m6lkrehi 5032 15 - - : cord-335975-m6lkrehi 5032 16 benzodiazepines benzodiazepine NNS cord-335975-m6lkrehi 5032 17 ( ( -LRB- cord-335975-m6lkrehi 5032 18 n n NN cord-335975-m6lkrehi 5032 19 = = SYM cord-335975-m6lkrehi 5032 20 17 17 CD cord-335975-m6lkrehi 5032 21 ) ) -RRB- cord-335975-m6lkrehi 5032 22 , , , cord-335975-m6lkrehi 5032 23 klippal klippal NNP cord-335975-m6lkrehi 5032 24 ( ( -LRB- cord-335975-m6lkrehi 5032 25 n n NN cord-335975-m6lkrehi 5032 26 = = SYM cord-335975-m6lkrehi 5032 27 2 2 CD cord-335975-m6lkrehi 5032 28 ) ) -RRB- cord-335975-m6lkrehi 5032 29 , , , cord-335975-m6lkrehi 5032 30 amisulpride amisulpride NNP cord-335975-m6lkrehi 5032 31 ( ( -LRB- cord-335975-m6lkrehi 5032 32 n n NN cord-335975-m6lkrehi 5032 33 = = SYM cord-335975-m6lkrehi 5032 34 1 1 CD cord-335975-m6lkrehi 5032 35 ) ) -RRB- cord-335975-m6lkrehi 5032 36 , , , cord-335975-m6lkrehi 5032 37 Non non JJ cord-335975-m6lkrehi 5032 38 - - JJ cord-335975-m6lkrehi 5032 39 steroidal steroidal JJ cord-335975-m6lkrehi 5032 40 anti anti JJ cord-335975-m6lkrehi 5032 41 - - JJ cord-335975-m6lkrehi 5032 42 inflammatory inflammatory JJ cord-335975-m6lkrehi 5032 43 drug drug NN cord-335975-m6lkrehi 5032 44 ( ( -LRB- cord-335975-m6lkrehi 5032 45 n n NN cord-335975-m6lkrehi 5032 46 = = SYM cord-335975-m6lkrehi 5032 47 1 1 CD cord-335975-m6lkrehi 5032 48 ) ) -RRB- cord-335975-m6lkrehi 5032 49 , , , cord-335975-m6lkrehi 5032 50 prazin prazin NNP cord-335975-m6lkrehi 5032 51 ( ( -LRB- cord-335975-m6lkrehi 5032 52 n n NN cord-335975-m6lkrehi 5032 53 = = SYM cord-335975-m6lkrehi 5032 54 1 1 CD cord-335975-m6lkrehi 5032 55 ) ) -RRB- cord-335975-m6lkrehi 5032 56 and and CC cord-335975-m6lkrehi 5032 57 promethazine promethazine NNP cord-335975-m6lkrehi 5032 58 ( ( -LRB- cord-335975-m6lkrehi 5032 59 n n NN cord-335975-m6lkrehi 5032 60 = = SYM cord-335975-m6lkrehi 5032 61 1 1 CD cord-335975-m6lkrehi 5032 62 ) ) -RRB- cord-335975-m6lkrehi 5032 63 . . . cord-335975-m6lkrehi 5033 1 Neurological neurological JJ cord-335975-m6lkrehi 5033 2 examination examination NN cord-335975-m6lkrehi 5033 3 found find VBD cord-335975-m6lkrehi 5033 4 drowsiness drowsiness NN cord-335975-m6lkrehi 5033 5 and and CC cord-335975-m6lkrehi 5033 6 mydriasis mydriasis NN cord-335975-m6lkrehi 5033 7 in in IN cord-335975-m6lkrehi 5033 8 46 46 CD cord-335975-m6lkrehi 5033 9 % % NN cord-335975-m6lkrehi 5033 10 of of IN cord-335975-m6lkrehi 5033 11 cases case NNS cord-335975-m6lkrehi 5033 12 ( ( -LRB- cord-335975-m6lkrehi 5033 13 n n NN cord-335975-m6lkrehi 5033 14 = = SYM cord-335975-m6lkrehi 5033 15 17 17 CD cord-335975-m6lkrehi 5033 16 ) ) -RRB- cord-335975-m6lkrehi 5033 17 , , , cord-335975-m6lkrehi 5033 18 coma coma NN cord-335975-m6lkrehi 5033 19 in in IN cord-335975-m6lkrehi 5033 20 13.5 13.5 CD cord-335975-m6lkrehi 5033 21 % % NN cord-335975-m6lkrehi 5033 22 ( ( -LRB- cord-335975-m6lkrehi 5033 23 n n NN cord-335975-m6lkrehi 5033 24 = = SYM cord-335975-m6lkrehi 5033 25 5 5 CD cord-335975-m6lkrehi 5033 26 ) ) -RRB- cord-335975-m6lkrehi 5033 27 , , , cord-335975-m6lkrehi 5033 28 agitation agitation NN cord-335975-m6lkrehi 5033 29 ( ( -LRB- cord-335975-m6lkrehi 5033 30 n n NN cord-335975-m6lkrehi 5033 31 = = SYM cord-335975-m6lkrehi 5033 32 5 5 CD cord-335975-m6lkrehi 5033 33 ) ) -RRB- cord-335975-m6lkrehi 5033 34 , , , cord-335975-m6lkrehi 5033 35 tremor tremor NN cord-335975-m6lkrehi 5033 36 ( ( -LRB- cord-335975-m6lkrehi 5033 37 n n NN cord-335975-m6lkrehi 5033 38 = = SYM cord-335975-m6lkrehi 5033 39 5 5 CD cord-335975-m6lkrehi 5033 40 ) ) -RRB- cord-335975-m6lkrehi 5033 41 , , , cord-335975-m6lkrehi 5033 42 hyperreflexia hyperreflexia NNP cord-335975-m6lkrehi 5033 43 ( ( -LRB- cord-335975-m6lkrehi 5033 44 n n NN cord-335975-m6lkrehi 5033 45 = = SYM cord-335975-m6lkrehi 5033 46 2 2 CD cord-335975-m6lkrehi 5033 47 ) ) -RRB- cord-335975-m6lkrehi 5033 48 , , , cord-335975-m6lkrehi 5033 49 hypersudation hypersudation NNP cord-335975-m6lkrehi 5033 50 ( ( -LRB- cord-335975-m6lkrehi 5033 51 n n NN cord-335975-m6lkrehi 5033 52 = = SYM cord-335975-m6lkrehi 5033 53 1 1 CD cord-335975-m6lkrehi 5033 54 ) ) -RRB- cord-335975-m6lkrehi 5033 55 , , , cord-335975-m6lkrehi 5033 56 fever fever NN cord-335975-m6lkrehi 5033 57 ( ( -LRB- cord-335975-m6lkrehi 5033 58 n n NN cord-335975-m6lkrehi 5033 59 = = SYM cord-335975-m6lkrehi 5033 60 1 1 CD cord-335975-m6lkrehi 5033 61 ) ) -RRB- cord-335975-m6lkrehi 5033 62 and and CC cord-335975-m6lkrehi 5033 63 diarrhea diarrhea NN cord-335975-m6lkrehi 5033 64 in in IN cord-335975-m6lkrehi 5033 65 one one CD cord-335975-m6lkrehi 5033 66 patient patient NN cord-335975-m6lkrehi 5033 67 . . . cord-335975-m6lkrehi 5034 1 The the DT cord-335975-m6lkrehi 5034 2 QT qt NN cord-335975-m6lkrehi 5034 3 was be VBD cord-335975-m6lkrehi 5034 4 lengthened lengthen VBN cord-335975-m6lkrehi 5034 5 in in IN cord-335975-m6lkrehi 5034 6 five five CD cord-335975-m6lkrehi 5034 7 cases case NNS cord-335975-m6lkrehi 5034 8 . . . cord-335975-m6lkrehi 5035 1 Treatment treatment NN cord-335975-m6lkrehi 5035 2 was be VBD cord-335975-m6lkrehi 5035 3 symptomatic symptomatic JJ cord-335975-m6lkrehi 5035 4 . . . cord-335975-m6lkrehi 5036 1 Five five CD cord-335975-m6lkrehi 5036 2 patients patient NNS cord-335975-m6lkrehi 5036 3 ( ( -LRB- cord-335975-m6lkrehi 5036 4 13.5 13.5 CD cord-335975-m6lkrehi 5036 5 % % NN cord-335975-m6lkrehi 5036 6 ) ) -RRB- cord-335975-m6lkrehi 5036 7 required require VBN cord-335975-m6lkrehi 5036 8 mechanical mechanical JJ cord-335975-m6lkrehi 5036 9 ventilation ventilation NN cord-335975-m6lkrehi 5036 10 with with IN cord-335975-m6lkrehi 5036 11 average average NN cord-335975-m6lkrehi 5036 12 of of IN cord-335975-m6lkrehi 5036 13 ventilation ventilation NN cord-335975-m6lkrehi 5036 14 duration duration NN cord-335975-m6lkrehi 5036 15 of of IN cord-335975-m6lkrehi 5036 16 21.2 21.2 CD cord-335975-m6lkrehi 5036 17 h. h. NN cord-335975-m6lkrehi 5037 1 All all DT cord-335975-m6lkrehi 5037 2 patients patient NNS cord-335975-m6lkrehi 5037 3 discharged discharge VBD cord-335975-m6lkrehi 5037 4 alive alive JJ cord-335975-m6lkrehi 5037 5 the the DT cord-335975-m6lkrehi 5037 6 ICU ICU NNP cord-335975-m6lkrehi 5037 7 . . . cord-335975-m6lkrehi 5038 1 Conclusion conclusion NN cord-335975-m6lkrehi 5038 2 : : : cord-335975-m6lkrehi 5038 3 SSRIs ssri NNS cord-335975-m6lkrehi 5038 4 poisoning poisoning NN cord-335975-m6lkrehi 5038 5 is be VBZ cord-335975-m6lkrehi 5038 6 mainly mainly RB cord-335975-m6lkrehi 5038 7 manifested manifest VBN cord-335975-m6lkrehi 5038 8 by by IN cord-335975-m6lkrehi 5038 9 serotonergic serotonergic JJ cord-335975-m6lkrehi 5038 10 syndrome syndrome NN cord-335975-m6lkrehi 5038 11 . . . cord-335975-m6lkrehi 5039 1 Evolution evolution NN cord-335975-m6lkrehi 5039 2 is be VBZ cord-335975-m6lkrehi 5039 3 favorable favorable JJ cord-335975-m6lkrehi 5039 4 in in IN cord-335975-m6lkrehi 5039 5 the the DT cord-335975-m6lkrehi 5039 6 majority majority NN cord-335975-m6lkrehi 5039 7 of of IN cord-335975-m6lkrehi 5039 8 cases case NNS cord-335975-m6lkrehi 5039 9 . . . cord-335975-m6lkrehi 5040 1 Mechanical mechanical JJ cord-335975-m6lkrehi 5040 2 ventilation ventilation NN cord-335975-m6lkrehi 5040 3 could could MD cord-335975-m6lkrehi 5040 4 be be VB cord-335975-m6lkrehi 5040 5 required require VBN cord-335975-m6lkrehi 5040 6 . . . cord-335975-m6lkrehi 5041 1 Hemodynamic Hemodynamic NNP cord-335975-m6lkrehi 5041 2 profile profile NN cord-335975-m6lkrehi 5041 3 of of IN cord-335975-m6lkrehi 5041 4 shocks shock NNS cord-335975-m6lkrehi 5041 5 induced induce VBN cord-335975-m6lkrehi 5041 6 by by IN cord-335975-m6lkrehi 5041 7 dihydropyridine dihydropyridine NNP cord-335975-m6lkrehi 5041 8 calcium calcium NN cord-335975-m6lkrehi 5041 9 channel channel NN cord-335975-m6lkrehi 5041 10 blocker blocker NN cord-335975-m6lkrehi 5041 11 poisoning poisoning NN cord-335975-m6lkrehi 5041 12 Khzouri Khzouri NNP cord-335975-m6lkrehi 5041 13 Takoua Takoua NNP cord-335975-m6lkrehi 5041 14 Introduction introduction NN cord-335975-m6lkrehi 5041 15 : : : cord-335975-m6lkrehi 5042 1 Acute acute JJ cord-335975-m6lkrehi 5042 2 Calcium Calcium NNP cord-335975-m6lkrehi 5042 3 Channel Channel NNP cord-335975-m6lkrehi 5042 4 Blockers Blockers NNP cord-335975-m6lkrehi 5042 5 ( ( -LRB- cord-335975-m6lkrehi 5042 6 CCB CCB NNP cord-335975-m6lkrehi 5042 7 ) ) -RRB- cord-335975-m6lkrehi 5042 8 poisoning poisoning NN cord-335975-m6lkrehi 5042 9 remains remain VBZ cord-335975-m6lkrehi 5042 10 infrequent infrequent JJ cord-335975-m6lkrehi 5042 11 despite despite IN cord-335975-m6lkrehi 5042 12 their -PRON- PRP$ cord-335975-m6lkrehi 5042 13 increasing increase VBG cord-335975-m6lkrehi 5042 14 use use NN cord-335975-m6lkrehi 5042 15 . . . cord-335975-m6lkrehi 5043 1 In in IN cord-335975-m6lkrehi 5043 2 our -PRON- PRP$ cord-335975-m6lkrehi 5043 3 country country NN cord-335975-m6lkrehi 5043 4 , , , cord-335975-m6lkrehi 5043 5 dihydropiridines dihydropiridine NNS cord-335975-m6lkrehi 5043 6 are be VBP cord-335975-m6lkrehi 5043 7 the the DT cord-335975-m6lkrehi 5043 8 most most RBS cord-335975-m6lkrehi 5043 9 prescribed prescribed JJ cord-335975-m6lkrehi 5043 10 ones one NNS cord-335975-m6lkrehi 5043 11 . . . cord-335975-m6lkrehi 5044 1 Very very RB cord-335975-m6lkrehi 5044 2 few few JJ cord-335975-m6lkrehi 5044 3 works work NNS cord-335975-m6lkrehi 5044 4 have have VBP cord-335975-m6lkrehi 5044 5 studied study VBN cord-335975-m6lkrehi 5044 6 the the DT cord-335975-m6lkrehi 5044 7 hemodynamic hemodynamic JJ cord-335975-m6lkrehi 5044 8 profile profile NN cord-335975-m6lkrehi 5044 9 of of IN cord-335975-m6lkrehi 5044 10 acute acute JJ cord-335975-m6lkrehi 5044 11 dihydropyridines dihydropyridine NNS cord-335975-m6lkrehi 5044 12 poisoning poisoning NN cord-335975-m6lkrehi 5044 13 either either CC cord-335975-m6lkrehi 5044 14 by by IN cord-335975-m6lkrehi 5044 15 invasive invasive JJ cord-335975-m6lkrehi 5044 16 means mean NNS cord-335975-m6lkrehi 5044 17 ( ( -LRB- cord-335975-m6lkrehi 5044 18 right right JJ cord-335975-m6lkrehi 5044 19 cardiac cardiac JJ cord-335975-m6lkrehi 5044 20 catheterization catheterization NN cord-335975-m6lkrehi 5044 21 , , , cord-335975-m6lkrehi 5044 22 transpulmonary transpulmonary NNP cord-335975-m6lkrehi 5044 23 thermodilution thermodilution NN cord-335975-m6lkrehi 5044 24 ) ) -RRB- cord-335975-m6lkrehi 5044 25 or or CC cord-335975-m6lkrehi 5044 26 non non JJ cord-335975-m6lkrehi 5044 27 - - JJ cord-335975-m6lkrehi 5044 28 invasive invasive JJ cord-335975-m6lkrehi 5044 29 ( ( -LRB- cord-335975-m6lkrehi 5044 30 cardiac cardiac JJ cord-335975-m6lkrehi 5044 31 ultrasound ultrasound NN cord-335975-m6lkrehi 5044 32 ) ) -RRB- cord-335975-m6lkrehi 5044 33 . . . cord-335975-m6lkrehi 5045 1 In in IN cord-335975-m6lkrehi 5045 2 this this DT cord-335975-m6lkrehi 5045 3 perspective perspective NN cord-335975-m6lkrehi 5045 4 , , , cord-335975-m6lkrehi 5045 5 we -PRON- PRP cord-335975-m6lkrehi 5045 6 carried carry VBD cord-335975-m6lkrehi 5045 7 out out RP cord-335975-m6lkrehi 5045 8 this this DT cord-335975-m6lkrehi 5045 9 study study NN cord-335975-m6lkrehi 5045 10 whose whose WP$ cord-335975-m6lkrehi 5045 11 main main JJ cord-335975-m6lkrehi 5045 12 objective objective NN cord-335975-m6lkrehi 5045 13 was be VBD cord-335975-m6lkrehi 5045 14 to to TO cord-335975-m6lkrehi 5045 15 illustrate illustrate VB cord-335975-m6lkrehi 5045 16 the the DT cord-335975-m6lkrehi 5045 17 different different JJ cord-335975-m6lkrehi 5045 18 hemodynamic hemodynamic JJ cord-335975-m6lkrehi 5045 19 profiles profile NNS cord-335975-m6lkrehi 5045 20 of of IN cord-335975-m6lkrehi 5045 21 shocks shock NNS cord-335975-m6lkrehi 5045 22 induced induce VBN cord-335975-m6lkrehi 5045 23 by by IN cord-335975-m6lkrehi 5045 24 dihydropyridine dihydropyridine NNP cord-335975-m6lkrehi 5045 25 CCB CCB NNP cord-335975-m6lkrehi 5045 26 Poisoning Poisoning NNP cord-335975-m6lkrehi 5045 27 . . . cord-335975-m6lkrehi 5046 1 Patients patient NNS cord-335975-m6lkrehi 5046 2 and and CC cord-335975-m6lkrehi 5046 3 methods method NNS cord-335975-m6lkrehi 5047 1 : : : cord-335975-m6lkrehi 5047 2 It -PRON- PRP cord-335975-m6lkrehi 5047 3 was be VBD cord-335975-m6lkrehi 5047 4 an an DT cord-335975-m6lkrehi 5047 5 observational observational JJ cord-335975-m6lkrehi 5047 6 retrospective retrospective JJ cord-335975-m6lkrehi 5047 7 study study NN cord-335975-m6lkrehi 5047 8 spread spread VBD cord-335975-m6lkrehi 5047 9 over over IN cord-335975-m6lkrehi 5047 10 12 12 CD cord-335975-m6lkrehi 5047 11 months month NNS cord-335975-m6lkrehi 5047 12 from from IN cord-335975-m6lkrehi 5047 13 1st 1st JJ cord-335975-m6lkrehi 5047 14 January January NNP cord-335975-m6lkrehi 5047 15 2016 2016 CD cord-335975-m6lkrehi 5047 16 to to IN cord-335975-m6lkrehi 5047 17 31th 31th NN cord-335975-m6lkrehi 5047 18 December December NNP cord-335975-m6lkrehi 5047 19 2016 2016 CD cord-335975-m6lkrehi 5047 20 in in IN cord-335975-m6lkrehi 5047 21 a a DT cord-335975-m6lkrehi 5047 22 teaching teaching NN cord-335975-m6lkrehi 5047 23 toxicological toxicological JJ cord-335975-m6lkrehi 5047 24 ICU ICU NNP cord-335975-m6lkrehi 5047 25 , , , cord-335975-m6lkrehi 5047 26 including include VBG cord-335975-m6lkrehi 5047 27 all all DT cord-335975-m6lkrehi 5047 28 patients patient NNS cord-335975-m6lkrehi 5047 29 admitted admit VBN cord-335975-m6lkrehi 5047 30 for for IN cord-335975-m6lkrehi 5047 31 acute acute JJ cord-335975-m6lkrehi 5047 32 dihydropyridine dihydropyridine NNP cord-335975-m6lkrehi 5047 33 CCB CCB NNP cord-335975-m6lkrehi 5047 34 poisoning poisoning NN cord-335975-m6lkrehi 5047 35 , , , cord-335975-m6lkrehi 5047 36 who who WP cord-335975-m6lkrehi 5047 37 presented present VBD cord-335975-m6lkrehi 5047 38 a a DT cord-335975-m6lkrehi 5047 39 shock shock NN cord-335975-m6lkrehi 5047 40 and and CC cord-335975-m6lkrehi 5047 41 underwent undergo VBD cord-335975-m6lkrehi 5047 42 right right JJ cord-335975-m6lkrehi 5047 43 hemodynamic hemodynamic JJ cord-335975-m6lkrehi 5047 44 exploration exploration NN cord-335975-m6lkrehi 5047 45 . . . cord-335975-m6lkrehi 5048 1 Results result NNS cord-335975-m6lkrehi 5048 2 : : : cord-335975-m6lkrehi 5049 1 During during IN cord-335975-m6lkrehi 5049 2 the the DT cord-335975-m6lkrehi 5049 3 study study NN cord-335975-m6lkrehi 5049 4 period period NN cord-335975-m6lkrehi 5049 5 , , , cord-335975-m6lkrehi 5049 6 CCB CCB NNP cord-335975-m6lkrehi 5049 7 poisoning poisoning NN cord-335975-m6lkrehi 5049 8 accounted account VBD cord-335975-m6lkrehi 5049 9 for for IN cord-335975-m6lkrehi 5049 10 3.15 3.15 CD cord-335975-m6lkrehi 5049 11 % % NN cord-335975-m6lkrehi 5049 12 ( ( -LRB- cord-335975-m6lkrehi 5049 13 n n NN cord-335975-m6lkrehi 5049 14 = = SYM cord-335975-m6lkrehi 5049 15 24 24 CD cord-335975-m6lkrehi 5049 16 ) ) -RRB- cord-335975-m6lkrehi 5049 17 of of IN cord-335975-m6lkrehi 5049 18 all all PDT cord-335975-m6lkrehi 5049 19 the the DT cord-335975-m6lkrehi 5049 20 acute acute JJ cord-335975-m6lkrehi 5049 21 poisoinings poisoining NNS cord-335975-m6lkrehi 5049 22 requiring require VBG cord-335975-m6lkrehi 5049 23 hospitalization hospitalization NN cord-335975-m6lkrehi 5049 24 in in IN cord-335975-m6lkrehi 5049 25 our -PRON- PRP$ cord-335975-m6lkrehi 5049 26 Intensive Intensive NNP cord-335975-m6lkrehi 5049 27 Care Care NNP cord-335975-m6lkrehi 5049 28 Unit Unit NNP cord-335975-m6lkrehi 5049 29 . . . cord-335975-m6lkrehi 5050 1 Among among IN cord-335975-m6lkrehi 5050 2 them -PRON- PRP cord-335975-m6lkrehi 5050 3 , , , cord-335975-m6lkrehi 5050 4 21 21 CD cord-335975-m6lkrehi 5050 5 had have VBD cord-335975-m6lkrehi 5050 6 taken take VBN cord-335975-m6lkrehi 5050 7 dihydropyridine dihydropyridine NN cord-335975-m6lkrehi 5050 8 which which WDT cord-335975-m6lkrehi 5050 9 represents represent VBZ cord-335975-m6lkrehi 5050 10 87.5 87.5 CD cord-335975-m6lkrehi 5050 11 % % NN cord-335975-m6lkrehi 5050 12 . . . cord-335975-m6lkrehi 5051 1 Four four CD cord-335975-m6lkrehi 5051 2 women woman NNS cord-335975-m6lkrehi 5051 3 aged age VBN cord-335975-m6lkrehi 5051 4 of of IN cord-335975-m6lkrehi 5051 5 29 29 CD cord-335975-m6lkrehi 5051 6 [ [ -LRB- cord-335975-m6lkrehi 5051 7 21 21 CD cord-335975-m6lkrehi 5051 8 , , , cord-335975-m6lkrehi 5051 9 47 47 CD cord-335975-m6lkrehi 5051 10 ] ] -RRB- cord-335975-m6lkrehi 5051 11 were be VBD cord-335975-m6lkrehi 5051 12 eligible eligible JJ cord-335975-m6lkrehi 5051 13 . . . cord-335975-m6lkrehi 5052 1 All all PDT cord-335975-m6lkrehi 5052 2 the the DT cord-335975-m6lkrehi 5052 3 exposures exposure NNS cord-335975-m6lkrehi 5052 4 were be VBD cord-335975-m6lkrehi 5052 5 single single JJ cord-335975-m6lkrehi 5052 6 - - HYPH cord-335975-m6lkrehi 5052 7 drug drug NN cord-335975-m6lkrehi 5052 8 . . . cord-335975-m6lkrehi 5053 1 The the DT cord-335975-m6lkrehi 5053 2 dihydropyridines dihydropyridine NNS cord-335975-m6lkrehi 5053 3 involved involve VBN cord-335975-m6lkrehi 5053 4 were be VBD cord-335975-m6lkrehi 5053 5 amlodipine amlodipine NN cord-335975-m6lkrehi 5053 6 in in IN cord-335975-m6lkrehi 5053 7 2 2 CD cord-335975-m6lkrehi 5053 8 cases case NNS cord-335975-m6lkrehi 5053 9 with with IN cord-335975-m6lkrehi 5053 10 a a DT cord-335975-m6lkrehi 5053 11 median median JJ cord-335975-m6lkrehi 5053 12 value value NN cord-335975-m6lkrehi 5053 13 of of IN cord-335975-m6lkrehi 5053 14 supposed suppose VBN cord-335975-m6lkrehi 5053 15 ingested ingest VBN cord-335975-m6lkrehi 5053 16 dose dose NN cord-335975-m6lkrehi 5053 17 ( ( -LRB- cord-335975-m6lkrehi 5053 18 SID SID NNP cord-335975-m6lkrehi 5053 19 ) ) -RRB- cord-335975-m6lkrehi 5053 20 of of IN cord-335975-m6lkrehi 5053 21 297.5 297.5 CD cord-335975-m6lkrehi 5053 22 mg mg CD cord-335975-m6lkrehi 5053 23 and and CC cord-335975-m6lkrehi 5053 24 nicardipine nicardipine NN cord-335975-m6lkrehi 5053 25 in in IN cord-335975-m6lkrehi 5053 26 the the DT cord-335975-m6lkrehi 5053 27 other other JJ cord-335975-m6lkrehi 5053 28 two two CD cord-335975-m6lkrehi 5053 29 ones one NNS cord-335975-m6lkrehi 5053 30 , , , cord-335975-m6lkrehi 5053 31 the the DT cord-335975-m6lkrehi 5053 32 median median JJ cord-335975-m6lkrehi 5053 33 SID SID NNP cord-335975-m6lkrehi 5053 34 was be VBD cord-335975-m6lkrehi 5053 35 1000 1000 CD cord-335975-m6lkrehi 5053 36 mg mg NN cord-335975-m6lkrehi 5053 37 . . . cord-335975-m6lkrehi 5054 1 The the DT cord-335975-m6lkrehi 5054 2 delay delay NN cord-335975-m6lkrehi 5054 3 of of IN cord-335975-m6lkrehi 5054 4 consultation consultation NN cord-335975-m6lkrehi 5054 5 was be VBD cord-335975-m6lkrehi 5054 6 of of IN cord-335975-m6lkrehi 5054 7 2.25 2.25 CD cord-335975-m6lkrehi 5054 8 ± ± NN cord-335975-m6lkrehi 5054 9 1 1 CD cord-335975-m6lkrehi 5054 10 h h NN cord-335975-m6lkrehi 5054 11 after after IN cord-335975-m6lkrehi 5054 12 ingestion ingestion NN cord-335975-m6lkrehi 5054 13 . . . cord-335975-m6lkrehi 5055 1 Gastrointestinal gastrointestinal JJ cord-335975-m6lkrehi 5055 2 decontamination decontamination NN cord-335975-m6lkrehi 5055 3 was be VBD cord-335975-m6lkrehi 5055 4 performed perform VBN cord-335975-m6lkrehi 5055 5 in in IN cord-335975-m6lkrehi 5055 6 one one CD cord-335975-m6lkrehi 5055 7 patient patient NN cord-335975-m6lkrehi 5055 8 with with IN cord-335975-m6lkrehi 5055 9 activated activate VBN cord-335975-m6lkrehi 5055 10 charcoal charcoal NN cord-335975-m6lkrehi 5055 11 . . . cord-335975-m6lkrehi 5056 1 The the DT cord-335975-m6lkrehi 5056 2 4 4 CD cord-335975-m6lkrehi 5056 3 patients patient NNS cord-335975-m6lkrehi 5056 4 developed develop VBD cord-335975-m6lkrehi 5056 5 a a DT cord-335975-m6lkrehi 5056 6 shock shock NN cord-335975-m6lkrehi 5056 7 within within IN cord-335975-m6lkrehi 5056 8 3 3 CD cord-335975-m6lkrehi 5056 9 h h NN cord-335975-m6lkrehi 5056 10 , , , cord-335975-m6lkrehi 5056 11 treated treat VBN cord-335975-m6lkrehi 5056 12 by by IN cord-335975-m6lkrehi 5056 13 initial initial JJ cord-335975-m6lkrehi 5056 14 vascular vascular JJ cord-335975-m6lkrehi 5056 15 filling filling NN cord-335975-m6lkrehi 5056 16 on on IN cord-335975-m6lkrehi 5056 17 average average JJ cord-335975-m6lkrehi 5056 18 1000 1000 CD cord-335975-m6lkrehi 5056 19 ml ml NNS cord-335975-m6lkrehi 5056 20 of of IN cord-335975-m6lkrehi 5056 21 crystalloids crystalloids NNP cord-335975-m6lkrehi 5056 22 , , , cord-335975-m6lkrehi 5056 23 noradrenaline noradrenaline NN cord-335975-m6lkrehi 5056 24 alone alone JJ cord-335975-m6lkrehi 5056 25 in in IN cord-335975-m6lkrehi 5056 26 3 3 CD cord-335975-m6lkrehi 5056 27 cases case NNS cord-335975-m6lkrehi 5056 28 and and CC cord-335975-m6lkrehi 5056 29 with with IN cord-335975-m6lkrehi 5056 30 a a DT cord-335975-m6lkrehi 5056 31 combination combination NN cord-335975-m6lkrehi 5056 32 of of IN cord-335975-m6lkrehi 5056 33 dobutamine dobutamine NN cord-335975-m6lkrehi 5056 34 in in IN cord-335975-m6lkrehi 5056 35 one one CD cord-335975-m6lkrehi 5056 36 patient patient NN cord-335975-m6lkrehi 5056 37 . . . cord-335975-m6lkrehi 5057 1 Other other JJ cord-335975-m6lkrehi 5057 2 adjuvant adjuvant JJ cord-335975-m6lkrehi 5057 3 treatments treatment NNS cord-335975-m6lkrehi 5057 4 ( ( -LRB- cord-335975-m6lkrehi 5057 5 high high JJ cord-335975-m6lkrehi 5057 6 dose dose NN cord-335975-m6lkrehi 5057 7 insulin insulin NN cord-335975-m6lkrehi 5057 8 , , , cord-335975-m6lkrehi 5057 9 calcium calcium NN cord-335975-m6lkrehi 5057 10 salts salt NNS cord-335975-m6lkrehi 5057 11 ) ) -RRB- cord-335975-m6lkrehi 5057 12 have have VBP cord-335975-m6lkrehi 5057 13 been be VBN cord-335975-m6lkrehi 5057 14 used use VBN cord-335975-m6lkrehi 5057 15 in in IN cord-335975-m6lkrehi 5057 16 all all DT cord-335975-m6lkrehi 5057 17 patients patient NNS cord-335975-m6lkrehi 5057 18 . . . cord-335975-m6lkrehi 5058 1 Their -PRON- PRP$ cord-335975-m6lkrehi 5058 2 hemodynamic hemodynamic JJ cord-335975-m6lkrehi 5058 3 profile profile NN cord-335975-m6lkrehi 5058 4 evaluation evaluation NN cord-335975-m6lkrehi 5058 5 by by IN cord-335975-m6lkrehi 5058 6 right right RB cord-335975-m6lkrehi 5058 7 - - HYPH cord-335975-m6lkrehi 5058 8 handed handed JJ cord-335975-m6lkrehi 5058 9 catheterization catheterization NN cord-335975-m6lkrehi 5058 10 Swan Swan NNP cord-335975-m6lkrehi 5058 11 - - HYPH cord-335975-m6lkrehi 5058 12 Ganz Ganz NNP cord-335975-m6lkrehi 5058 13 was be VBD cord-335975-m6lkrehi 5058 14 in in IN cord-335975-m6lkrehi 5058 15 favour favour NN cord-335975-m6lkrehi 5058 16 of of IN cord-335975-m6lkrehi 5058 17 vasoplegia vasoplegia NN cord-335975-m6lkrehi 5058 18 in in IN cord-335975-m6lkrehi 5058 19 3 3 CD cord-335975-m6lkrehi 5058 20 cases case NNS cord-335975-m6lkrehi 5058 21 with with IN cord-335975-m6lkrehi 5058 22 median median JJ cord-335975-m6lkrehi 5058 23 values value NNS cord-335975-m6lkrehi 5058 24 of of IN cord-335975-m6lkrehi 5058 25 systemic systemic JJ cord-335975-m6lkrehi 5058 26 vascular vascular JJ cord-335975-m6lkrehi 5058 27 resistances resistance NNS cord-335975-m6lkrehi 5058 28 ( ( -LRB- cord-335975-m6lkrehi 5058 29 SVR SVR NNP cord-335975-m6lkrehi 5058 30 ) ) -RRB- cord-335975-m6lkrehi 5058 31 of of IN cord-335975-m6lkrehi 5058 32 224 224 CD cord-335975-m6lkrehi 5058 33 dynes.s.cm-5 dynes.s.cm-5 NNP cord-335975-m6lkrehi 5058 34 , , , cord-335975-m6lkrehi 5058 35 of of IN cord-335975-m6lkrehi 5058 36 cardiac cardiac NNP cord-335975-m6lkrehi 5058 37 Output Output NNP cord-335975-m6lkrehi 5058 38 ( ( -LRB- cord-335975-m6lkrehi 5058 39 CO CO NNP cord-335975-m6lkrehi 5058 40 ) ) -RRB- cord-335975-m6lkrehi 5058 41 of of IN cord-335975-m6lkrehi 5058 42 14 14 CD cord-335975-m6lkrehi 5058 43 ( ( -LRB- cord-335975-m6lkrehi 5058 44 L L NNP cord-335975-m6lkrehi 5058 45 min min NNP cord-335975-m6lkrehi 5058 46 ) ) -RRB- cord-335975-m6lkrehi 5058 47 , , , cord-335975-m6lkrehi 5058 48 and and CC cord-335975-m6lkrehi 5058 49 of of IN cord-335975-m6lkrehi 5058 50 the the DT cord-335975-m6lkrehi 5058 51 arteriovenous arteriovenous JJ cord-335975-m6lkrehi 5058 52 oxygen oxygen NN cord-335975-m6lkrehi 5058 53 difference difference NN cord-335975-m6lkrehi 5058 54 of of IN cord-335975-m6lkrehi 5058 55 4.76 4.76 CD cord-335975-m6lkrehi 5058 56 . . . cord-335975-m6lkrehi 5059 1 The the DT cord-335975-m6lkrehi 5059 2 fourth fourth JJ cord-335975-m6lkrehi 5059 3 patient patient NN cord-335975-m6lkrehi 5059 4 's 's POS cord-335975-m6lkrehi 5059 5 shock shock NN cord-335975-m6lkrehi 5059 6 had have VBD cord-335975-m6lkrehi 5059 7 mixed mix VBN cord-335975-m6lkrehi 5059 8 nature nature NN cord-335975-m6lkrehi 5059 9 with with IN cord-335975-m6lkrehi 5059 10 SVR SVR NNP cord-335975-m6lkrehi 5059 11 of of IN cord-335975-m6lkrehi 5059 12 507 507 CD cord-335975-m6lkrehi 5059 13 dynes.s.cm-5 dynes.s.cm-5 NNP cord-335975-m6lkrehi 5059 14 and and CC cord-335975-m6lkrehi 5059 15 CO CO NNP cord-335975-m6lkrehi 5059 16 of of IN cord-335975-m6lkrehi 5059 17 3.7 3.7 CD cord-335975-m6lkrehi 5059 18 ( ( -LRB- cord-335975-m6lkrehi 5059 19 L L NNP cord-335975-m6lkrehi 5059 20 min min NNP cord-335975-m6lkrehi 5059 21 ) ) -RRB- cord-335975-m6lkrehi 5059 22 . . . cord-335975-m6lkrehi 5060 1 All all DT cord-335975-m6lkrehi 5060 2 patients patient NNS cord-335975-m6lkrehi 5060 3 were be VBD cord-335975-m6lkrehi 5060 4 discharged discharge VBN cord-335975-m6lkrehi 5060 5 from from IN cord-335975-m6lkrehi 5060 6 the the DT cord-335975-m6lkrehi 5060 7 ICU ICU NNP cord-335975-m6lkrehi 5060 8 with with IN cord-335975-m6lkrehi 5060 9 a a DT cord-335975-m6lkrehi 5060 10 mean mean JJ cord-335975-m6lkrehi 5060 11 length length NN cord-335975-m6lkrehi 5060 12 of of IN cord-335975-m6lkrehi 5060 13 stay stay NN cord-335975-m6lkrehi 5060 14 of of IN cord-335975-m6lkrehi 5060 15 14 14 CD cord-335975-m6lkrehi 5060 16 days day NNS cord-335975-m6lkrehi 5060 17 . . . cord-335975-m6lkrehi 5061 1 Conclusion conclusion NN cord-335975-m6lkrehi 5061 2 : : : cord-335975-m6lkrehi 5062 1 The the DT cord-335975-m6lkrehi 5062 2 dihydropyridine dihydropyridine NN cord-335975-m6lkrehi 5062 3 calcium calcium NN cord-335975-m6lkrehi 5062 4 channel channel NN cord-335975-m6lkrehi 5062 5 blockers blocker NNS cord-335975-m6lkrehi 5062 6 poisoning poisoning NN cord-335975-m6lkrehi 5062 7 exposes expose VBZ cord-335975-m6lkrehi 5062 8 to to IN cord-335975-m6lkrehi 5062 9 the the DT cord-335975-m6lkrehi 5062 10 shock shock NN cord-335975-m6lkrehi 5062 11 risk risk NN cord-335975-m6lkrehi 5062 12 due due IN cord-335975-m6lkrehi 5062 13 to to IN cord-335975-m6lkrehi 5062 14 several several JJ cord-335975-m6lkrehi 5062 15 mechanisms mechanism NNS cord-335975-m6lkrehi 5062 16 . . . cord-335975-m6lkrehi 5063 1 The the DT cord-335975-m6lkrehi 5063 2 clinician clinician NN cord-335975-m6lkrehi 5063 3 must must MD cord-335975-m6lkrehi 5063 4 be be VB cord-335975-m6lkrehi 5063 5 warned warn VBN cord-335975-m6lkrehi 5063 6 to to TO cord-335975-m6lkrehi 5063 7 look look VB cord-335975-m6lkrehi 5063 8 for for IN cord-335975-m6lkrehi 5063 9 signs sign NNS cord-335975-m6lkrehi 5063 10 of of IN cord-335975-m6lkrehi 5063 11 severity severity NN cord-335975-m6lkrehi 5063 12 and and CC cord-335975-m6lkrehi 5063 13 understand understand VB cord-335975-m6lkrehi 5063 14 its -PRON- PRP$ cord-335975-m6lkrehi 5063 15 mechanisms mechanism NNS cord-335975-m6lkrehi 5063 16 by by IN cord-335975-m6lkrehi 5063 17 using use VBG cord-335975-m6lkrehi 5063 18 the the DT cord-335975-m6lkrehi 5063 19 hemodynamic hemodynamic JJ cord-335975-m6lkrehi 5063 20 study study NN cord-335975-m6lkrehi 5063 21 in in IN cord-335975-m6lkrehi 5063 22 order order NN cord-335975-m6lkrehi 5063 23 to to TO cord-335975-m6lkrehi 5063 24 improve improve VB cord-335975-m6lkrehi 5063 25 its -PRON- PRP$ cord-335975-m6lkrehi 5063 26 management management NN cord-335975-m6lkrehi 5063 27 . . . cord-335975-m6lkrehi 5064 1 Goulmane Goulmane NNP cord-335975-m6lkrehi 5064 2 Mourad Mourad NNP cord-335975-m6lkrehi 5064 3 1 1 CD cord-335975-m6lkrehi 5064 4 , , , cord-335975-m6lkrehi 5064 5 Alachaher Alachaher NNP cord-335975-m6lkrehi 5064 6 Djamel Djamel NNP cord-335975-m6lkrehi 5064 7 1 1 CD cord-335975-m6lkrehi 5064 8 , , , cord-335975-m6lkrehi 5064 9 Djebli Djebli NNP cord-335975-m6lkrehi 5064 10 Houria Houria NNP cord-335975-m6lkrehi 5064 11 1 1 CD cord-335975-m6lkrehi 5064 12 Introduction introduction NN cord-335975-m6lkrehi 5064 13 : : : cord-335975-m6lkrehi 5065 1 In in IN cord-335975-m6lkrehi 5065 2 daily daily JJ cord-335975-m6lkrehi 5065 3 practice practice NN cord-335975-m6lkrehi 5065 4 , , , cord-335975-m6lkrehi 5065 5 admission admission NN cord-335975-m6lkrehi 5065 6 to to IN cord-335975-m6lkrehi 5065 7 the the DT cord-335975-m6lkrehi 5065 8 intensive intensive JJ cord-335975-m6lkrehi 5065 9 care care NN cord-335975-m6lkrehi 5065 10 unit unit NN cord-335975-m6lkrehi 5065 11 ( ( -LRB- cord-335975-m6lkrehi 5065 12 ICU ICU NNP cord-335975-m6lkrehi 5065 13 ) ) -RRB- cord-335975-m6lkrehi 5065 14 usually usually RB cord-335975-m6lkrehi 5065 15 does do VBZ cord-335975-m6lkrehi 5065 16 not not RB cord-335975-m6lkrehi 5065 17 raise raise VB cord-335975-m6lkrehi 5065 18 any any DT cord-335975-m6lkrehi 5065 19 major major JJ cord-335975-m6lkrehi 5065 20 ethical ethical JJ cord-335975-m6lkrehi 5065 21 problems problem NNS cord-335975-m6lkrehi 5065 22 . . . cord-335975-m6lkrehi 5066 1 Difficulties difficulty NNS cord-335975-m6lkrehi 5066 2 arise arise VBP cord-335975-m6lkrehi 5066 3 mainly mainly RB cord-335975-m6lkrehi 5066 4 in in IN cord-335975-m6lkrehi 5066 5 acute acute JJ cord-335975-m6lkrehi 5066 6 situations situation NNS cord-335975-m6lkrehi 5066 7 requiring require VBG cord-335975-m6lkrehi 5066 8 intensive intensive JJ cord-335975-m6lkrehi 5066 9 care care NN cord-335975-m6lkrehi 5066 10 that that WDT cord-335975-m6lkrehi 5066 11 have have VBP cord-335975-m6lkrehi 5066 12 not not RB cord-335975-m6lkrehi 5066 13 been be VBN cord-335975-m6lkrehi 5066 14 anticipated anticipate VBN cord-335975-m6lkrehi 5066 15 and and CC cord-335975-m6lkrehi 5066 16 therefore therefore RB cord-335975-m6lkrehi 5066 17 , , , cord-335975-m6lkrehi 5066 18 not not RB cord-335975-m6lkrehi 5066 19 adequately adequately RB cord-335975-m6lkrehi 5066 20 prepared prepared JJ cord-335975-m6lkrehi 5066 21 and and CC cord-335975-m6lkrehi 5066 22 discussed discuss VBN cord-335975-m6lkrehi 5066 23 . . . cord-335975-m6lkrehi 5067 1 We -PRON- PRP cord-335975-m6lkrehi 5067 2 hypothesized hypothesize VBD cord-335975-m6lkrehi 5067 3 that that IN cord-335975-m6lkrehi 5067 4 non non JJ cord-335975-m6lkrehi 5067 5 - - JJ cord-335975-m6lkrehi 5067 6 admission admission NN cord-335975-m6lkrehi 5067 7 of of IN cord-335975-m6lkrehi 5067 8 a a DT cord-335975-m6lkrehi 5067 9 patient patient NN cord-335975-m6lkrehi 5067 10 to to IN cord-335975-m6lkrehi 5067 11 the the DT cord-335975-m6lkrehi 5067 12 ICU ICU NNP cord-335975-m6lkrehi 5067 13 must must MD cord-335975-m6lkrehi 5067 14 occur occur VB cord-335975-m6lkrehi 5067 15 in in IN cord-335975-m6lkrehi 5067 16 the the DT cord-335975-m6lkrehi 5067 17 following follow VBG cord-335975-m6lkrehi 5067 18 circumstances-(1 circumstances-(1 NN cord-335975-m6lkrehi 5067 19 ) ) -RRB- cord-335975-m6lkrehi 5068 1 with with IN cord-335975-m6lkrehi 5068 2 the the DT cord-335975-m6lkrehi 5068 3 patient patient NN cord-335975-m6lkrehi 5068 4 's 's POS cord-335975-m6lkrehi 5068 5 agreement agreement NN cord-335975-m6lkrehi 5068 6 , , , cord-335975-m6lkrehi 5068 7 expressed express VBD cord-335975-m6lkrehi 5068 8 either either CC cord-335975-m6lkrehi 5068 9 directly directly RB cord-335975-m6lkrehi 5068 10 or or CC cord-335975-m6lkrehi 5068 11 through through IN cord-335975-m6lkrehi 5068 12 advance advance NN cord-335975-m6lkrehi 5068 13 directives directive NNS cord-335975-m6lkrehi 5068 14 ( ( -LRB- cord-335975-m6lkrehi 5068 15 AD ad NN cord-335975-m6lkrehi 5068 16 ) ) -RRB- cord-335975-m6lkrehi 5068 17 , , , cord-335975-m6lkrehi 5068 18 or or CC cord-335975-m6lkrehi 5068 19 as as IN cord-335975-m6lkrehi 5068 20 relayed relay VBN cord-335975-m6lkrehi 5068 21 by by IN cord-335975-m6lkrehi 5068 22 a a DT cord-335975-m6lkrehi 5068 23 surrogate surrogate NN cord-335975-m6lkrehi 5068 24 or or CC cord-335975-m6lkrehi 5068 25 the the DT cord-335975-m6lkrehi 5068 26 family family NN cord-335975-m6lkrehi 5068 27 + + CC cord-335975-m6lkrehi 5068 28 ( ( -LRB- cord-335975-m6lkrehi 5068 29 2 2 LS cord-335975-m6lkrehi 5068 30 ) ) -RRB- cord-335975-m6lkrehi 5068 31 according accord VBG cord-335975-m6lkrehi 5068 32 to to IN cord-335975-m6lkrehi 5068 33 a a DT cord-335975-m6lkrehi 5068 34 collegial collegial JJ cord-335975-m6lkrehi 5068 35 decision decision NN cord-335975-m6lkrehi 5068 36 - - HYPH cord-335975-m6lkrehi 5068 37 making making NN cord-335975-m6lkrehi 5068 38 process process NN cord-335975-m6lkrehi 5068 39 ( ( -LRB- cord-335975-m6lkrehi 5068 40 if if IN cord-335975-m6lkrehi 5068 41 the the DT cord-335975-m6lkrehi 5068 42 patient patient NN cord-335975-m6lkrehi 5068 43 is be VBZ cord-335975-m6lkrehi 5068 44 decisionally decisionally RB cord-335975-m6lkrehi 5068 45 incapacitated incapacitate VBN cord-335975-m6lkrehi 5068 46 ) ) -RRB- cord-335975-m6lkrehi 5068 47 + + CC cord-335975-m6lkrehi 5068 48 and and CC cord-335975-m6lkrehi 5068 49 ( ( -LRB- cord-335975-m6lkrehi 5068 50 3 3 LS cord-335975-m6lkrehi 5068 51 ) ) -RRB- cord-335975-m6lkrehi 5068 52 after after IN cord-335975-m6lkrehi 5068 53 seeking seek VBG cord-335975-m6lkrehi 5068 54 the the DT cord-335975-m6lkrehi 5068 55 opinion opinion NN cord-335975-m6lkrehi 5068 56 of of IN cord-335975-m6lkrehi 5068 57 an an DT cord-335975-m6lkrehi 5068 58 external external JJ cord-335975-m6lkrehi 5068 59 consultant consultant NN cord-335975-m6lkrehi 5068 60 . . . cord-335975-m6lkrehi 5069 1 The the DT cord-335975-m6lkrehi 5069 2 decision decision NN cord-335975-m6lkrehi 5069 3 - - HYPH cord-335975-m6lkrehi 5069 4 making making NN cord-335975-m6lkrehi 5069 5 process process NN cord-335975-m6lkrehi 5069 6 must must MD cord-335975-m6lkrehi 5069 7 be be VB cord-335975-m6lkrehi 5069 8 documented document VBN cord-335975-m6lkrehi 5069 9 in in IN cord-335975-m6lkrehi 5069 10 the the DT cord-335975-m6lkrehi 5069 11 patient patient NN cord-335975-m6lkrehi 5069 12 's 's POS cord-335975-m6lkrehi 5069 13 medical medical JJ cord-335975-m6lkrehi 5069 14 file file NN cord-335975-m6lkrehi 5069 15 . . . cord-335975-m6lkrehi 5070 1 Patients patient NNS cord-335975-m6lkrehi 5070 2 and and CC cord-335975-m6lkrehi 5070 3 methods method NNS cord-335975-m6lkrehi 5070 4 : : : cord-335975-m6lkrehi 5070 5 Prospective prospective JJ cord-335975-m6lkrehi 5070 6 , , , cord-335975-m6lkrehi 5070 7 observational observational JJ cord-335975-m6lkrehi 5070 8 study study NN cord-335975-m6lkrehi 5070 9 in in IN cord-335975-m6lkrehi 5070 10 two two CD cord-335975-m6lkrehi 5070 11 hospitals hospital NNS cord-335975-m6lkrehi 5070 12 ( ( -LRB- cord-335975-m6lkrehi 5070 13 one one CD cord-335975-m6lkrehi 5070 14 large large JJ cord-335975-m6lkrehi 5070 15 university university NN cord-335975-m6lkrehi 5070 16 hospital hospital NN cord-335975-m6lkrehi 5070 17 , , , cord-335975-m6lkrehi 5070 18 one one CD cord-335975-m6lkrehi 5070 19 regional regional JJ cord-335975-m6lkrehi 5070 20 non non JJ cord-335975-m6lkrehi 5070 21 - - JJ cord-335975-m6lkrehi 5070 22 acamedic acamedic JJ cord-335975-m6lkrehi 5070 23 hospital hospital NN cord-335975-m6lkrehi 5070 24 ) ) -RRB- cord-335975-m6lkrehi 5070 25 over over IN cord-335975-m6lkrehi 5070 26 a a DT cord-335975-m6lkrehi 5070 27 period period NN cord-335975-m6lkrehi 5070 28 of of IN cord-335975-m6lkrehi 5070 29 2 2 CD cord-335975-m6lkrehi 5070 30 months month NNS cord-335975-m6lkrehi 5070 31 . . . cord-335975-m6lkrehi 5071 1 Inclusion inclusion NN cord-335975-m6lkrehi 5071 2 criteria criterion NNS cord-335975-m6lkrehi 5071 3 were be VBD cord-335975-m6lkrehi 5071 4 - - HYPH cord-335975-m6lkrehi 5071 5 patients patient NNS cord-335975-m6lkrehi 5071 6 aged age VBN cord-335975-m6lkrehi 5071 7 ≥ ≥ CD cord-335975-m6lkrehi 5071 8 18 18 CD cord-335975-m6lkrehi 5071 9 years year NNS cord-335975-m6lkrehi 5071 10 presenting present VBG cord-335975-m6lkrehi 5071 11 with with IN cord-335975-m6lkrehi 5071 12 failure failure NN cord-335975-m6lkrehi 5071 13 of of IN cord-335975-m6lkrehi 5071 14 at at RB cord-335975-m6lkrehi 5071 15 least least JJS cord-335975-m6lkrehi 5071 16 1 1 CD cord-335975-m6lkrehi 5071 17 organ organ NN cord-335975-m6lkrehi 5071 18 that that WDT cord-335975-m6lkrehi 5071 19 was be VBD cord-335975-m6lkrehi 5071 20 directly directly RB cord-335975-m6lkrehi 5071 21 life life NN cord-335975-m6lkrehi 5071 22 - - HYPH cord-335975-m6lkrehi 5071 23 threatening threaten VBG cord-335975-m6lkrehi 5071 24 and and CC cord-335975-m6lkrehi 5071 25 requiring require VBG cord-335975-m6lkrehi 5071 26 life life NN cord-335975-m6lkrehi 5071 27 - - HYPH cord-335975-m6lkrehi 5071 28 sustaining sustain VBG cord-335975-m6lkrehi 5071 29 therapies therapy NNS cord-335975-m6lkrehi 5071 30 . . . cord-335975-m6lkrehi 5072 1 Complete complete JJ cord-335975-m6lkrehi 5072 2 data datum NNS cord-335975-m6lkrehi 5072 3 collection collection NN cord-335975-m6lkrehi 5072 4 was be VBD cord-335975-m6lkrehi 5072 5 performed perform VBN cord-335975-m6lkrehi 5072 6 for for IN cord-335975-m6lkrehi 5072 7 each each DT cord-335975-m6lkrehi 5072 8 patient patient NN cord-335975-m6lkrehi 5072 9 . . . cord-335975-m6lkrehi 5073 1 Results result NNS cord-335975-m6lkrehi 5073 2 : : : cord-335975-m6lkrehi 5074 1 A a DT cord-335975-m6lkrehi 5074 2 total total NN cord-335975-m6lkrehi 5074 3 of of IN cord-335975-m6lkrehi 5074 4 31 31 CD cord-335975-m6lkrehi 5074 5 patients patient NNS cord-335975-m6lkrehi 5074 6 were be VBD cord-335975-m6lkrehi 5074 7 included include VBN cord-335975-m6lkrehi 5074 8 ( ( -LRB- cord-335975-m6lkrehi 5074 9 61 61 CD cord-335975-m6lkrehi 5074 10 % % NN cord-335975-m6lkrehi 5074 11 from from IN cord-335975-m6lkrehi 5074 12 the the DT cord-335975-m6lkrehi 5074 13 emergency emergency NN cord-335975-m6lkrehi 5074 14 department department NN cord-335975-m6lkrehi 5074 15 and and CC cord-335975-m6lkrehi 5074 16 39 39 CD cord-335975-m6lkrehi 5074 17 % % NN cord-335975-m6lkrehi 5074 18 from from IN cord-335975-m6lkrehi 5074 19 medical medical JJ cord-335975-m6lkrehi 5074 20 wards ward NNS cord-335975-m6lkrehi 5074 21 ) ) -RRB- cord-335975-m6lkrehi 5074 22 . . . cord-335975-m6lkrehi 5075 1 The the DT cord-335975-m6lkrehi 5075 2 decision decision NN cord-335975-m6lkrehi 5075 3 not not RB cord-335975-m6lkrehi 5075 4 to to TO cord-335975-m6lkrehi 5075 5 admit admit VB cord-335975-m6lkrehi 5075 6 the the DT cord-335975-m6lkrehi 5075 7 patient patient NN cord-335975-m6lkrehi 5075 8 to to IN cord-335975-m6lkrehi 5075 9 the the DT cord-335975-m6lkrehi 5075 10 ICU ICU NNP cord-335975-m6lkrehi 5075 11 was be VBD cord-335975-m6lkrehi 5075 12 taken-(1 taken-(1 NNP cord-335975-m6lkrehi 5075 13 ) ) -RRB- cord-335975-m6lkrehi 5075 14 during during IN cord-335975-m6lkrehi 5075 15 night night NN cord-335975-m6lkrehi 5075 16 duty duty NN cord-335975-m6lkrehi 5075 17 for for IN cord-335975-m6lkrehi 5075 18 19 19 CD cord-335975-m6lkrehi 5075 19 patients patient NNS cord-335975-m6lkrehi 5075 20 ( ( -LRB- cord-335975-m6lkrehi 5075 21 61 61 CD cord-335975-m6lkrehi 5075 22 % % NN cord-335975-m6lkrehi 5075 23 ) ) -RRB- cord-335975-m6lkrehi 5075 24 + + NN cord-335975-m6lkrehi 5075 25 ( ( -LRB- cord-335975-m6lkrehi 5075 26 2 2 LS cord-335975-m6lkrehi 5075 27 ) ) -RRB- cord-335975-m6lkrehi 5075 28 by by IN cord-335975-m6lkrehi 5075 29 a a DT cord-335975-m6lkrehi 5075 30 senior senior JJ cord-335975-m6lkrehi 5075 31 physician physician NN cord-335975-m6lkrehi 5075 32 in in IN cord-335975-m6lkrehi 5075 33 100 100 CD cord-335975-m6lkrehi 5075 34 % % NN cord-335975-m6lkrehi 5075 35 , , , cord-335975-m6lkrehi 5075 36 and and CC cord-335975-m6lkrehi 5075 37 ( ( -LRB- cord-335975-m6lkrehi 5075 38 3 3 LS cord-335975-m6lkrehi 5075 39 ) ) -RRB- cord-335975-m6lkrehi 5075 40 after after IN cord-335975-m6lkrehi 5075 41 clinical clinical JJ cord-335975-m6lkrehi 5075 42 examination examination NN cord-335975-m6lkrehi 5075 43 in in IN cord-335975-m6lkrehi 5075 44 25 25 CD cord-335975-m6lkrehi 5075 45 ( ( -LRB- cord-335975-m6lkrehi 5075 46 80 80 CD cord-335975-m6lkrehi 5075 47 % % NN cord-335975-m6lkrehi 5075 48 ) ) -RRB- cord-335975-m6lkrehi 5075 49 . . . cord-335975-m6lkrehi 5076 1 The the DT cord-335975-m6lkrehi 5076 2 main main JJ cord-335975-m6lkrehi 5076 3 reasons reason NNS cord-335975-m6lkrehi 5076 4 justifying justify VBG cord-335975-m6lkrehi 5076 5 the the DT cord-335975-m6lkrehi 5076 6 decision decision NN cord-335975-m6lkrehi 5076 7 not not RB cord-335975-m6lkrehi 5076 8 to to TO cord-335975-m6lkrehi 5076 9 admit admit VB cord-335975-m6lkrehi 5076 10 to to IN cord-335975-m6lkrehi 5076 11 the the DT cord-335975-m6lkrehi 5076 12 ICU ICU NNP cord-335975-m6lkrehi 5076 13 were-(1 were-(1 NN cord-335975-m6lkrehi 5076 14 ) ) -RRB- cord-335975-m6lkrehi 5076 15 metastatic metastatic JJ cord-335975-m6lkrehi 5076 16 cancer cancer NN cord-335975-m6lkrehi 5076 17 in in IN cord-335975-m6lkrehi 5076 18 8 8 CD cord-335975-m6lkrehi 5076 19 patients patient NNS cord-335975-m6lkrehi 5076 20 ( ( -LRB- cord-335975-m6lkrehi 5076 21 26 26 CD cord-335975-m6lkrehi 5076 22 % % NN cord-335975-m6lkrehi 5076 23 ) ) -RRB- cord-335975-m6lkrehi 5076 24 + + NN cord-335975-m6lkrehi 5076 25 ( ( -LRB- cord-335975-m6lkrehi 5076 26 2 2 LS cord-335975-m6lkrehi 5076 27 ) ) -RRB- cord-335975-m6lkrehi 5076 28 total total JJ cord-335975-m6lkrehi 5076 29 loss loss NN cord-335975-m6lkrehi 5076 30 of of IN cord-335975-m6lkrehi 5076 31 autonomy autonomy NN cord-335975-m6lkrehi 5076 32 in in IN cord-335975-m6lkrehi 5076 33 8 8 CD cord-335975-m6lkrehi 5076 34 ( ( -LRB- cord-335975-m6lkrehi 5076 35 26 26 CD cord-335975-m6lkrehi 5076 36 % % NN cord-335975-m6lkrehi 5076 37 ) ) -RRB- cord-335975-m6lkrehi 5076 38 + + NN cord-335975-m6lkrehi 5076 39 ( ( -LRB- cord-335975-m6lkrehi 5076 40 3 3 LS cord-335975-m6lkrehi 5076 41 ) ) -RRB- cord-335975-m6lkrehi 5076 42 severe severe JJ cord-335975-m6lkrehi 5076 43 cognitive cognitive JJ cord-335975-m6lkrehi 5076 44 impairment impairment NN cord-335975-m6lkrehi 5076 45 in in IN cord-335975-m6lkrehi 5076 46 4 4 CD cord-335975-m6lkrehi 5076 47 ( ( -LRB- cord-335975-m6lkrehi 5076 48 13 13 CD cord-335975-m6lkrehi 5076 49 % % NN cord-335975-m6lkrehi 5076 50 ) ) -RRB- cord-335975-m6lkrehi 5076 51 + + NN cord-335975-m6lkrehi 5076 52 ( ( -LRB- cord-335975-m6lkrehi 5076 53 4 4 LS cord-335975-m6lkrehi 5076 54 ) ) -RRB- cord-335975-m6lkrehi 5076 55 premorbid premorbid NN cord-335975-m6lkrehi 5076 56 state state NN cord-335975-m6lkrehi 5076 57 in in IN cord-335975-m6lkrehi 5076 58 1 1 CD cord-335975-m6lkrehi 5076 59 ( ( -LRB- cord-335975-m6lkrehi 5076 60 3 3 CD cord-335975-m6lkrehi 5076 61 % % NN cord-335975-m6lkrehi 5076 62 ) ) -RRB- cord-335975-m6lkrehi 5076 63 + + NN cord-335975-m6lkrehi 5076 64 ( ( -LRB- cord-335975-m6lkrehi 5076 65 5 5 LS cord-335975-m6lkrehi 5076 66 ) ) -RRB- cord-335975-m6lkrehi 5076 67 chronic chronic JJ cord-335975-m6lkrehi 5076 68 organ organ NN cord-335975-m6lkrehi 5076 69 failure failure NN cord-335975-m6lkrehi 5076 70 for for IN cord-335975-m6lkrehi 5076 71 2 2 CD cord-335975-m6lkrehi 5076 72 ( ( -LRB- cord-335975-m6lkrehi 5076 73 5 5 CD cord-335975-m6lkrehi 5076 74 % % NN cord-335975-m6lkrehi 5076 75 ) ) -RRB- cord-335975-m6lkrehi 5076 76 + + SYM cord-335975-m6lkrehi 5076 77 and and CC cord-335975-m6lkrehi 5076 78 ( ( -LRB- cord-335975-m6lkrehi 5076 79 6 6 LS cord-335975-m6lkrehi 5076 80 ) ) -RRB- cord-335975-m6lkrehi 5076 81 presence presence NN cord-335975-m6lkrehi 5076 82 of of IN cord-335975-m6lkrehi 5076 83 AD ad NN cord-335975-m6lkrehi 5076 84 ( ( -LRB- cord-335975-m6lkrehi 5076 85 written write VBN cord-335975-m6lkrehi 5076 86 or or CC cord-335975-m6lkrehi 5076 87 oral oral JJ cord-335975-m6lkrehi 5076 88 ) ) -RRB- cord-335975-m6lkrehi 5076 89 specifying specify VBG cord-335975-m6lkrehi 5076 90 that that IN cord-335975-m6lkrehi 5076 91 the the DT cord-335975-m6lkrehi 5076 92 patient patient NN cord-335975-m6lkrehi 5076 93 did do VBD cord-335975-m6lkrehi 5076 94 not not RB cord-335975-m6lkrehi 5076 95 wish wish VB cord-335975-m6lkrehi 5076 96 to to TO cord-335975-m6lkrehi 5076 97 be be VB cord-335975-m6lkrehi 5076 98 admitted admit VBN cord-335975-m6lkrehi 5076 99 to to IN cord-335975-m6lkrehi 5076 100 the the DT cord-335975-m6lkrehi 5076 101 ICU ICU NNP cord-335975-m6lkrehi 5076 102 in in IN cord-335975-m6lkrehi 5076 103 8 8 CD cord-335975-m6lkrehi 5076 104 ( ( -LRB- cord-335975-m6lkrehi 5076 105 26 26 CD cord-335975-m6lkrehi 5076 106 % % NN cord-335975-m6lkrehi 5076 107 ) ) -RRB- cord-335975-m6lkrehi 5076 108 . . . cord-335975-m6lkrehi 5077 1 This this DT cord-335975-m6lkrehi 5077 2 study study NN cord-335975-m6lkrehi 5077 3 raises raise VBZ cord-335975-m6lkrehi 5077 4 several several JJ cord-335975-m6lkrehi 5077 5 points point NNS cord-335975-m6lkrehi 5077 6 concerning concern VBG cord-335975-m6lkrehi 5077 7 the the DT cord-335975-m6lkrehi 5077 8 decision decision NN cord-335975-m6lkrehi 5077 9 - - HYPH cord-335975-m6lkrehi 5077 10 making make VBG cord-335975-m6lkrehi 5077 11 process process NN cord-335975-m6lkrehi 5077 12 for for IN cord-335975-m6lkrehi 5077 13 patients patient NNS cord-335975-m6lkrehi 5077 14 requiring require VBG cord-335975-m6lkrehi 5077 15 intensive intensive JJ cord-335975-m6lkrehi 5077 16 care care NN cord-335975-m6lkrehi 5077 17 . . . cord-335975-m6lkrehi 5078 1 First first RB cord-335975-m6lkrehi 5078 2 , , , cord-335975-m6lkrehi 5078 3 collegiality collegiality NN cord-335975-m6lkrehi 5078 4 is be VBZ cord-335975-m6lkrehi 5078 5 observed observe VBN cord-335975-m6lkrehi 5078 6 in in IN cord-335975-m6lkrehi 5078 7 almost almost RB cord-335975-m6lkrehi 5078 8 all all DT cord-335975-m6lkrehi 5078 9 situations situation NNS cord-335975-m6lkrehi 5078 10 of of IN cord-335975-m6lkrehi 5078 11 non non JJ cord-335975-m6lkrehi 5078 12 - - JJ cord-335975-m6lkrehi 5078 13 admission admission JJ cord-335975-m6lkrehi 5078 14 ( ( -LRB- cord-335975-m6lkrehi 5078 15 97 97 CD cord-335975-m6lkrehi 5078 16 % % NN cord-335975-m6lkrehi 5078 17 ) ) -RRB- cord-335975-m6lkrehi 5078 18 . . . cord-335975-m6lkrehi 5079 1 Second second RB cord-335975-m6lkrehi 5079 2 , , , cord-335975-m6lkrehi 5079 3 an an DT cord-335975-m6lkrehi 5079 4 outside outside JJ cord-335975-m6lkrehi 5079 5 consultant consultant NN cord-335975-m6lkrehi 5079 6 was be VBD cord-335975-m6lkrehi 5079 7 contacted contact VBN cord-335975-m6lkrehi 5079 8 in in IN cord-335975-m6lkrehi 5079 9 around around RB cord-335975-m6lkrehi 5079 10 30 30 CD cord-335975-m6lkrehi 5079 11 % % NN cord-335975-m6lkrehi 5079 12 of of IN cord-335975-m6lkrehi 5079 13 cases case NNS cord-335975-m6lkrehi 5079 14 . . . cord-335975-m6lkrehi 5080 1 Third third JJ cord-335975-m6lkrehi 5080 2 , , , cord-335975-m6lkrehi 5080 3 26 26 CD cord-335975-m6lkrehi 5080 4 % % NN cord-335975-m6lkrehi 5080 5 of of IN cord-335975-m6lkrehi 5080 6 patients patient NNS cord-335975-m6lkrehi 5080 7 had have VBD cord-335975-m6lkrehi 5080 8 AD ad NN cord-335975-m6lkrehi 5080 9 . . . cord-335975-m6lkrehi 5081 1 Fourth fourth RB cord-335975-m6lkrehi 5081 2 , , , cord-335975-m6lkrehi 5081 3 the the DT cord-335975-m6lkrehi 5081 4 family family NN cord-335975-m6lkrehi 5081 5 or or CC cord-335975-m6lkrehi 5081 6 entourage entourage NN cord-335975-m6lkrehi 5081 7 were be VBD cord-335975-m6lkrehi 5081 8 consulted consult VBN cord-335975-m6lkrehi 5081 9 in in IN cord-335975-m6lkrehi 5081 10 less less JJR cord-335975-m6lkrehi 5081 11 than than IN cord-335975-m6lkrehi 5081 12 40 40 CD cord-335975-m6lkrehi 5081 13 % % NN cord-335975-m6lkrehi 5081 14 of of IN cord-335975-m6lkrehi 5081 15 cases case NNS cord-335975-m6lkrehi 5081 16 and and CC cord-335975-m6lkrehi 5081 17 finally finally RB cord-335975-m6lkrehi 5081 18 , , , cord-335975-m6lkrehi 5081 19 in in IN cord-335975-m6lkrehi 5081 20 around around RB cord-335975-m6lkrehi 5081 21 75 75 CD cord-335975-m6lkrehi 5081 22 % % NN cord-335975-m6lkrehi 5081 23 of of IN cord-335975-m6lkrehi 5081 24 cases case NNS cord-335975-m6lkrehi 5081 25 , , , cord-335975-m6lkrehi 5081 26 the the DT cord-335975-m6lkrehi 5081 27 decision decision NN cord-335975-m6lkrehi 5081 28 - - HYPH cord-335975-m6lkrehi 5081 29 making making NN cord-335975-m6lkrehi 5081 30 process process NN cord-335975-m6lkrehi 5081 31 was be VBD cord-335975-m6lkrehi 5081 32 documented document VBN cord-335975-m6lkrehi 5081 33 . . . cord-335975-m6lkrehi 5082 1 Conclusion conclusion NN cord-335975-m6lkrehi 5082 2 : : : cord-335975-m6lkrehi 5083 1 This this DT cord-335975-m6lkrehi 5083 2 study study NN cord-335975-m6lkrehi 5083 3 shows show VBZ cord-335975-m6lkrehi 5083 4 that that IN cord-335975-m6lkrehi 5083 5 in in IN cord-335975-m6lkrehi 5083 6 emergency emergency NN cord-335975-m6lkrehi 5083 7 situations situation NNS cord-335975-m6lkrehi 5083 8 , , , cord-335975-m6lkrehi 5083 9 it -PRON- PRP cord-335975-m6lkrehi 5083 10 is be VBZ cord-335975-m6lkrehi 5083 11 more more RBR cord-335975-m6lkrehi 5083 12 difficult difficult JJ cord-335975-m6lkrehi 5083 13 to to TO cord-335975-m6lkrehi 5083 14 take take VB cord-335975-m6lkrehi 5083 15 adequately adequately RB cord-335975-m6lkrehi 5083 16 structured structured JJ cord-335975-m6lkrehi 5083 17 decisions decision NNS cord-335975-m6lkrehi 5083 18 regarding regard VBG cord-335975-m6lkrehi 5083 19 ICU ICU NNP cord-335975-m6lkrehi 5083 20 admission admission NN cord-335975-m6lkrehi 5083 21 than than IN cord-335975-m6lkrehi 5083 22 , , , cord-335975-m6lkrehi 5083 23 for for IN cord-335975-m6lkrehi 5083 24 example example NN cord-335975-m6lkrehi 5083 25 , , , cord-335975-m6lkrehi 5083 26 decisions decision NNS cord-335975-m6lkrehi 5083 27 regarding regard VBG cord-335975-m6lkrehi 5083 28 limitation limitation NN cord-335975-m6lkrehi 5083 29 or or CC cord-335975-m6lkrehi 5083 30 withdrawal withdrawal NN cord-335975-m6lkrehi 5083 31 of of IN cord-335975-m6lkrehi 5083 32 treatment treatment NN cord-335975-m6lkrehi 5083 33 in in IN cord-335975-m6lkrehi 5083 34 the the DT cord-335975-m6lkrehi 5083 35 ICU ICU NNP cord-335975-m6lkrehi 5083 36 . . . cord-335975-m6lkrehi 5084 1 Introduction introduction NN cord-335975-m6lkrehi 5084 2 : : : cord-335975-m6lkrehi 5085 1 As as IN cord-335975-m6lkrehi 5085 2 known know VBN cord-335975-m6lkrehi 5085 3 , , , cord-335975-m6lkrehi 5085 4 tracheostomy tracheostomy NN cord-335975-m6lkrehi 5085 5 is be VBZ cord-335975-m6lkrehi 5085 6 performed perform VBN cord-335975-m6lkrehi 5085 7 to to TO cord-335975-m6lkrehi 5085 8 improve improve VB cord-335975-m6lkrehi 5085 9 quality quality NN cord-335975-m6lkrehi 5085 10 of of IN cord-335975-m6lkrehi 5085 11 life life NN cord-335975-m6lkrehi 5085 12 ( ( -LRB- cord-335975-m6lkrehi 5085 13 QOL QOL NNP cord-335975-m6lkrehi 5085 14 ) ) -RRB- cord-335975-m6lkrehi 5085 15 in in IN cord-335975-m6lkrehi 5085 16 patients patient NNS cord-335975-m6lkrehi 5085 17 requiring require VBG cord-335975-m6lkrehi 5085 18 prolonged prolong VBN cord-335975-m6lkrehi 5085 19 mechanical mechanical JJ cord-335975-m6lkrehi 5085 20 ventilation ventilation NN cord-335975-m6lkrehi 5085 21 . . . cord-335975-m6lkrehi 5086 1 It -PRON- PRP cord-335975-m6lkrehi 5086 2 is be VBZ cord-335975-m6lkrehi 5086 3 indicated indicate VBN cord-335975-m6lkrehi 5086 4 to to TO cord-335975-m6lkrehi 5086 5 facilitate facilitate VB cord-335975-m6lkrehi 5086 6 care care NN cord-335975-m6lkrehi 5086 7 of of IN cord-335975-m6lkrehi 5086 8 critically critically RB cord-335975-m6lkrehi 5086 9 ill ill JJ cord-335975-m6lkrehi 5086 10 patients patient NNS cord-335975-m6lkrehi 5086 11 , , , cord-335975-m6lkrehi 5086 12 in in IN cord-335975-m6lkrehi 5086 13 order order NN cord-335975-m6lkrehi 5086 14 to to TO cord-335975-m6lkrehi 5086 15 minimize minimize VB cord-335975-m6lkrehi 5086 16 risks risk NNS cord-335975-m6lkrehi 5086 17 of of IN cord-335975-m6lkrehi 5086 18 oro oro JJ cord-335975-m6lkrehi 5086 19 - - HYPH cord-335975-m6lkrehi 5086 20 tracheal tracheal JJ cord-335975-m6lkrehi 5086 21 intubation intubation NN cord-335975-m6lkrehi 5086 22 , , , cord-335975-m6lkrehi 5086 23 and and CC cord-335975-m6lkrehi 5086 24 enhance enhance VB cord-335975-m6lkrehi 5086 25 recovery recovery NN cord-335975-m6lkrehi 5086 26 , , , cord-335975-m6lkrehi 5086 27 allowing allow VBG cord-335975-m6lkrehi 5086 28 early early JJ cord-335975-m6lkrehi 5086 29 discharge discharge NN cord-335975-m6lkrehi 5086 30 from from IN cord-335975-m6lkrehi 5086 31 ICU ICU NNP cord-335975-m6lkrehi 5086 32 with with IN cord-335975-m6lkrehi 5086 33 home home NN cord-335975-m6lkrehi 5086 34 ventilation ventilation NN cord-335975-m6lkrehi 5086 35 . . . cord-335975-m6lkrehi 5087 1 We -PRON- PRP cord-335975-m6lkrehi 5087 2 aimed aim VBN cord-335975-m6lkrehi 5087 3 by by IN cord-335975-m6lkrehi 5087 4 this this DT cord-335975-m6lkrehi 5087 5 study study NN cord-335975-m6lkrehi 5087 6 to to TO cord-335975-m6lkrehi 5087 7 evaluate evaluate VB cord-335975-m6lkrehi 5087 8 long long JJ cord-335975-m6lkrehi 5087 9 - - HYPH cord-335975-m6lkrehi 5087 10 term term NN cord-335975-m6lkrehi 5087 11 survival survival NN cord-335975-m6lkrehi 5087 12 and and CC cord-335975-m6lkrehi 5087 13 QOL QOL NNP cord-335975-m6lkrehi 5087 14 in in IN cord-335975-m6lkrehi 5087 15 Tunisian tunisian JJ cord-335975-m6lkrehi 5087 16 patients patient NNS cord-335975-m6lkrehi 5087 17 discharged discharge VBD cord-335975-m6lkrehi 5087 18 from from IN cord-335975-m6lkrehi 5087 19 the the DT cord-335975-m6lkrehi 5087 20 ICU ICU NNP cord-335975-m6lkrehi 5087 21 with with IN cord-335975-m6lkrehi 5087 22 tracheostomy tracheostomy NN cord-335975-m6lkrehi 5087 23 , , , cord-335975-m6lkrehi 5087 24 as as RB cord-335975-m6lkrehi 5087 25 well well RB cord-335975-m6lkrehi 5087 26 as as IN cord-335975-m6lkrehi 5087 27 related related JJ cord-335975-m6lkrehi 5087 28 burden burden NN cord-335975-m6lkrehi 5087 29 assumed assume VBN cord-335975-m6lkrehi 5087 30 by by IN cord-335975-m6lkrehi 5087 31 their -PRON- PRP$ cord-335975-m6lkrehi 5087 32 relatives relative NNS cord-335975-m6lkrehi 5087 33 . . . cord-335975-m6lkrehi 5088 1 Patients patient NNS cord-335975-m6lkrehi 5088 2 and and CC cord-335975-m6lkrehi 5088 3 methods method NNS cord-335975-m6lkrehi 5088 4 : : : cord-335975-m6lkrehi 5088 5 Patients patient NNS cord-335975-m6lkrehi 5088 6 who who WP cord-335975-m6lkrehi 5088 7 were be VBD cord-335975-m6lkrehi 5088 8 admitted admit VBN cord-335975-m6lkrehi 5088 9 to to IN cord-335975-m6lkrehi 5088 10 the the DT cord-335975-m6lkrehi 5088 11 ICU ICU NNP cord-335975-m6lkrehi 5088 12 between between IN cord-335975-m6lkrehi 5088 13 2015 2015 CD cord-335975-m6lkrehi 5088 14 and and CC cord-335975-m6lkrehi 5088 15 2017 2017 CD cord-335975-m6lkrehi 5088 16 were be VBD cord-335975-m6lkrehi 5088 17 eligible eligible JJ cord-335975-m6lkrehi 5088 18 for for IN cord-335975-m6lkrehi 5088 19 inclusion inclusion NN cord-335975-m6lkrehi 5088 20 in in IN cord-335975-m6lkrehi 5088 21 this this DT cord-335975-m6lkrehi 5088 22 retrospective retrospective JJ cord-335975-m6lkrehi 5088 23 cohort cohort NN cord-335975-m6lkrehi 5088 24 if if IN cord-335975-m6lkrehi 5088 25 they -PRON- PRP cord-335975-m6lkrehi 5088 26 had have VBD cord-335975-m6lkrehi 5088 27 a a DT cord-335975-m6lkrehi 5088 28 tracheostomy tracheostomy NN cord-335975-m6lkrehi 5088 29 during during IN cord-335975-m6lkrehi 5088 30 their -PRON- PRP$ cord-335975-m6lkrehi 5088 31 ICU ICU NNP cord-335975-m6lkrehi 5088 32 stay stay NN cord-335975-m6lkrehi 5088 33 , , , cord-335975-m6lkrehi 5088 34 and and CC cord-335975-m6lkrehi 5088 35 were be VBD cord-335975-m6lkrehi 5088 36 discharged discharge VBN cord-335975-m6lkrehi 5088 37 at at IN cord-335975-m6lkrehi 5088 38 home home NN cord-335975-m6lkrehi 5088 39 with with IN cord-335975-m6lkrehi 5088 40 a a DT cord-335975-m6lkrehi 5088 41 tracheostomy tracheostomy NN cord-335975-m6lkrehi 5088 42 canula canula NN cord-335975-m6lkrehi 5088 43 . . . cord-335975-m6lkrehi 5089 1 For for IN cord-335975-m6lkrehi 5089 2 survivors survivor NNS cord-335975-m6lkrehi 5089 3 , , , cord-335975-m6lkrehi 5089 4 we -PRON- PRP cord-335975-m6lkrehi 5089 5 used use VBD cord-335975-m6lkrehi 5089 6 the the DT cord-335975-m6lkrehi 5089 7 Short Short NNP cord-335975-m6lkrehi 5089 8 Form Form NNP cord-335975-m6lkrehi 5089 9 Health Health NNP cord-335975-m6lkrehi 5089 10 survey survey NN cord-335975-m6lkrehi 5089 11 ( ( -LRB- cord-335975-m6lkrehi 5089 12 SF12 SF12 NNP cord-335975-m6lkrehi 5089 13 ) ) -RRB- cord-335975-m6lkrehi 5089 14 to to TO cord-335975-m6lkrehi 5089 15 assess assess VB cord-335975-m6lkrehi 5089 16 their -PRON- PRP$ cord-335975-m6lkrehi 5089 17 QOL QOL NNP cord-335975-m6lkrehi 5089 18 at at IN cord-335975-m6lkrehi 5089 19 home home NN cord-335975-m6lkrehi 5089 20 . . . cord-335975-m6lkrehi 5090 1 We -PRON- PRP cord-335975-m6lkrehi 5090 2 estimated estimate VBD cord-335975-m6lkrehi 5090 3 the the DT cord-335975-m6lkrehi 5090 4 degree degree NN cord-335975-m6lkrehi 5090 5 of of IN cord-335975-m6lkrehi 5090 6 autonomy autonomy NN cord-335975-m6lkrehi 5090 7 using use VBG cord-335975-m6lkrehi 5090 8 the the DT cord-335975-m6lkrehi 5090 9 ADL ADL NNP cord-335975-m6lkrehi 5090 10 scale scale NN cord-335975-m6lkrehi 5090 11 . . . cord-335975-m6lkrehi 5091 1 To to TO cord-335975-m6lkrehi 5091 2 assess assess VB cord-335975-m6lkrehi 5091 3 burden burden NN cord-335975-m6lkrehi 5091 4 assumed assume VBN cord-335975-m6lkrehi 5091 5 by by IN cord-335975-m6lkrehi 5091 6 caregivers caregiver NNS cord-335975-m6lkrehi 5091 7 ( ( -LRB- cord-335975-m6lkrehi 5091 8 family family NN cord-335975-m6lkrehi 5091 9 members member NNS cord-335975-m6lkrehi 5091 10 most most JJS cord-335975-m6lkrehi 5091 11 of of IN cord-335975-m6lkrehi 5091 12 the the DT cord-335975-m6lkrehi 5091 13 time time NN cord-335975-m6lkrehi 5091 14 ) ) -RRB- cord-335975-m6lkrehi 5091 15 we -PRON- PRP cord-335975-m6lkrehi 5091 16 used use VBD cord-335975-m6lkrehi 5091 17 the the DT cord-335975-m6lkrehi 5091 18 short short JJ cord-335975-m6lkrehi 5091 19 version version NN cord-335975-m6lkrehi 5091 20 of of IN cord-335975-m6lkrehi 5091 21 Zarit Zarit NNP cord-335975-m6lkrehi 5091 22 burden burden NN cord-335975-m6lkrehi 5091 23 interview interview NN cord-335975-m6lkrehi 5091 24 . . . cord-335975-m6lkrehi 5092 1 Exclusion exclusion NN cord-335975-m6lkrehi 5092 2 criteria criterion NNS cord-335975-m6lkrehi 5092 3 were be VBD cord-335975-m6lkrehi 5092 4 refusal refusal NN cord-335975-m6lkrehi 5092 5 of of IN cord-335975-m6lkrehi 5092 6 the the DT cord-335975-m6lkrehi 5092 7 interview interview NN cord-335975-m6lkrehi 5092 8 or or CC cord-335975-m6lkrehi 5092 9 unavailability unavailability NN cord-335975-m6lkrehi 5092 10 on on IN cord-335975-m6lkrehi 5092 11 the the DT cord-335975-m6lkrehi 5092 12 phone phone NN cord-335975-m6lkrehi 5092 13 call call NN cord-335975-m6lkrehi 5092 14 . . . cord-335975-m6lkrehi 5093 1 Results result NNS cord-335975-m6lkrehi 5093 2 : : : cord-335975-m6lkrehi 5094 1 Fourteen fourteen CD cord-335975-m6lkrehi 5094 2 patients patient NNS cord-335975-m6lkrehi 5094 3 were be VBD cord-335975-m6lkrehi 5094 4 discharged discharge VBN cord-335975-m6lkrehi 5094 5 at at IN cord-335975-m6lkrehi 5094 6 home home NN cord-335975-m6lkrehi 5094 7 with with IN cord-335975-m6lkrehi 5094 8 a a DT cord-335975-m6lkrehi 5094 9 tracheostomy tracheostomy NN cord-335975-m6lkrehi 5094 10 canula canula NN cord-335975-m6lkrehi 5094 11 . . . cord-335975-m6lkrehi 5095 1 Only only RB cord-335975-m6lkrehi 5095 2 twelve twelve CD cord-335975-m6lkrehi 5095 3 responded respond VBD cord-335975-m6lkrehi 5095 4 to to IN cord-335975-m6lkrehi 5095 5 the the DT cord-335975-m6lkrehi 5095 6 phone phone NN cord-335975-m6lkrehi 5095 7 call call NN cord-335975-m6lkrehi 5095 8 . . . cord-335975-m6lkrehi 5096 1 Four four CD cord-335975-m6lkrehi 5096 2 patients patient NNS cord-335975-m6lkrehi 5096 3 died die VBD cord-335975-m6lkrehi 5096 4 1 1 CD cord-335975-m6lkrehi 5096 5 month month NN cord-335975-m6lkrehi 5096 6 later later RB cord-335975-m6lkrehi 5096 7 . . . cord-335975-m6lkrehi 5097 1 Amoung Amoung NNP cord-335975-m6lkrehi 5097 2 the the DT cord-335975-m6lkrehi 5097 3 8 8 CD cord-335975-m6lkrehi 5097 4 survivors survivor NNS cord-335975-m6lkrehi 5097 5 , , , cord-335975-m6lkrehi 5097 6 the the DT cord-335975-m6lkrehi 5097 7 removal removal NN cord-335975-m6lkrehi 5097 8 of of IN cord-335975-m6lkrehi 5097 9 the the DT cord-335975-m6lkrehi 5097 10 tracheostomy tracheostomy NN cord-335975-m6lkrehi 5097 11 canula canula NN cord-335975-m6lkrehi 5097 12 was be VBD cord-335975-m6lkrehi 5097 13 successful successful JJ cord-335975-m6lkrehi 5097 14 in in IN cord-335975-m6lkrehi 5097 15 3 3 CD cord-335975-m6lkrehi 5097 16 patients patient NNS cord-335975-m6lkrehi 5097 17 after after IN cord-335975-m6lkrehi 5097 18 a a DT cord-335975-m6lkrehi 5097 19 mean mean JJ cord-335975-m6lkrehi 5097 20 duration duration NN cord-335975-m6lkrehi 5097 21 of of IN cord-335975-m6lkrehi 5097 22 30 30 CD cord-335975-m6lkrehi 5097 23 days day NNS cord-335975-m6lkrehi 5097 24 . . . cord-335975-m6lkrehi 5098 1 Main main JJ cord-335975-m6lkrehi 5098 2 findings finding NNS cord-335975-m6lkrehi 5098 3 are be VBP cord-335975-m6lkrehi 5098 4 summarized summarize VBN cord-335975-m6lkrehi 5098 5 in in IN cord-335975-m6lkrehi 5098 6 Table Table NNP cord-335975-m6lkrehi 5098 7 1 1 CD cord-335975-m6lkrehi 5098 8 . . . cord-335975-m6lkrehi 5099 1 Conclusion conclusion NN cord-335975-m6lkrehi 5099 2 : : : cord-335975-m6lkrehi 5100 1 Tracheostomy tracheostomy NN cord-335975-m6lkrehi 5100 2 shows show VBZ cord-335975-m6lkrehi 5100 3 good good JJ cord-335975-m6lkrehi 5100 4 acceptance acceptance NN cord-335975-m6lkrehi 5100 5 and and CC cord-335975-m6lkrehi 5100 6 acceptable acceptable JJ cord-335975-m6lkrehi 5100 7 QOL QOL NNP cord-335975-m6lkrehi 5100 8 . . . cord-335975-m6lkrehi 5101 1 It -PRON- PRP cord-335975-m6lkrehi 5101 2 allowed allow VBD cord-335975-m6lkrehi 5101 3 shorter short JJR cord-335975-m6lkrehi 5101 4 length length NN cord-335975-m6lkrehi 5101 5 of of IN cord-335975-m6lkrehi 5101 6 stay stay NN cord-335975-m6lkrehi 5101 7 in in IN cord-335975-m6lkrehi 5101 8 the the DT cord-335975-m6lkrehi 5101 9 ICU ICU NNP cord-335975-m6lkrehi 5101 10 and and CC cord-335975-m6lkrehi 5101 11 long long JJ cord-335975-m6lkrehi 5101 12 - - HYPH cord-335975-m6lkrehi 5101 13 term term NN cord-335975-m6lkrehi 5101 14 survival survival NN cord-335975-m6lkrehi 5101 15 after after IN cord-335975-m6lkrehi 5101 16 discharge discharge NN cord-335975-m6lkrehi 5101 17 from from IN cord-335975-m6lkrehi 5101 18 the the DT cord-335975-m6lkrehi 5101 19 ICU ICU NNP cord-335975-m6lkrehi 5101 20 , , , cord-335975-m6lkrehi 5101 21 and and CC cord-335975-m6lkrehi 5101 22 should should MD cord-335975-m6lkrehi 5101 23 be be VB cord-335975-m6lkrehi 5101 24 encouraged encourage VBN cord-335975-m6lkrehi 5101 25 for for IN cord-335975-m6lkrehi 5101 26 Tunisian tunisian JJ cord-335975-m6lkrehi 5101 27 patients patient NNS cord-335975-m6lkrehi 5101 28 . . . cord-335975-m6lkrehi 5102 1 In in IN cord-335975-m6lkrehi 5102 2 contrast contrast NN cord-335975-m6lkrehi 5102 3 , , , cord-335975-m6lkrehi 5102 4 the the DT cord-335975-m6lkrehi 5102 5 QOL QOL NNP cord-335975-m6lkrehi 5102 6 of of IN cord-335975-m6lkrehi 5102 7 patients patient NNS cord-335975-m6lkrehi 5102 8 ' ' POS cord-335975-m6lkrehi 5102 9 relatives relative NNS cord-335975-m6lkrehi 5102 10 was be VBD cord-335975-m6lkrehi 5102 11 more more RBR cord-335975-m6lkrehi 5102 12 affected affect VBN cord-335975-m6lkrehi 5102 13 , , , cord-335975-m6lkrehi 5102 14 with with IN cord-335975-m6lkrehi 5102 15 significant significant JJ cord-335975-m6lkrehi 5102 16 burden burden NN cord-335975-m6lkrehi 5102 17 and and CC cord-335975-m6lkrehi 5102 18 work work NN cord-335975-m6lkrehi 5102 19 load load NN cord-335975-m6lkrehi 5102 20 . . . cord-335975-m6lkrehi 5103 1 Introduction introduction NN cord-335975-m6lkrehi 5103 2 : : : cord-335975-m6lkrehi 5103 3 Intensive intensive JJ cord-335975-m6lkrehi 5103 4 care care NN cord-335975-m6lkrehi 5103 5 survivors survivor NNS cord-335975-m6lkrehi 5103 6 present present VBP cord-335975-m6lkrehi 5103 7 often often RB cord-335975-m6lkrehi 5103 8 some some DT cord-335975-m6lkrehi 5103 9 psychological psychological JJ cord-335975-m6lkrehi 5103 10 disorders disorder NNS cord-335975-m6lkrehi 5103 11 linked link VBN cord-335975-m6lkrehi 5103 12 with with IN cord-335975-m6lkrehi 5103 13 experience experience NN cord-335975-m6lkrehi 5103 14 memory memory NN cord-335975-m6lkrehi 5103 15 loss loss NN cord-335975-m6lkrehi 5103 16 or or CC cord-335975-m6lkrehi 5103 17 nightmares nightmare NNS cord-335975-m6lkrehi 5103 18 . . . cord-335975-m6lkrehi 5104 1 The the DT cord-335975-m6lkrehi 5104 2 use use NN cord-335975-m6lkrehi 5104 3 of of IN cord-335975-m6lkrehi 5104 4 patient patient JJ cord-335975-m6lkrehi 5104 5 diaries diary NNS cord-335975-m6lkrehi 5104 6 has have VBZ cord-335975-m6lkrehi 5104 7 been be VBN cord-335975-m6lkrehi 5104 8 developed develop VBN cord-335975-m6lkrehi 5104 9 and and CC cord-335975-m6lkrehi 5104 10 implemented implement VBN cord-335975-m6lkrehi 5104 11 by by IN cord-335975-m6lkrehi 5104 12 clinical clinical JJ cord-335975-m6lkrehi 5104 13 staff staff NN cord-335975-m6lkrehi 5104 14 to to TO cord-335975-m6lkrehi 5104 15 improve improve VB cord-335975-m6lkrehi 5104 16 the the DT cord-335975-m6lkrehi 5104 17 quality quality NN cord-335975-m6lkrehi 5104 18 of of IN cord-335975-m6lkrehi 5104 19 life life NN cord-335975-m6lkrehi 5104 20 after after IN cord-335975-m6lkrehi 5104 21 intensive intensive JJ cord-335975-m6lkrehi 5104 22 care care NN cord-335975-m6lkrehi 5104 23 . . . cord-335975-m6lkrehi 5105 1 Patients patient NNS cord-335975-m6lkrehi 5105 2 received receive VBD cord-335975-m6lkrehi 5105 3 their -PRON- PRP$ cord-335975-m6lkrehi 5105 4 diaries diary NNS cord-335975-m6lkrehi 5105 5 at at IN cord-335975-m6lkrehi 5105 6 ICU ICU NNP cord-335975-m6lkrehi 5105 7 discharge discharge NN cord-335975-m6lkrehi 5105 8 . . . cord-335975-m6lkrehi 5106 1 This this DT cord-335975-m6lkrehi 5106 2 study study NN cord-335975-m6lkrehi 5106 3 was be VBD cord-335975-m6lkrehi 5106 4 conducted conduct VBN cord-335975-m6lkrehi 5106 5 in in IN cord-335975-m6lkrehi 5106 6 order order NN cord-335975-m6lkrehi 5106 7 to to TO cord-335975-m6lkrehi 5106 8 understand understand VB cord-335975-m6lkrehi 5106 9 the the DT cord-335975-m6lkrehi 5106 10 potential potential JJ cord-335975-m6lkrehi 5106 11 benefits benefit NNS cord-335975-m6lkrehi 5106 12 for for IN cord-335975-m6lkrehi 5106 13 patients patient NNS cord-335975-m6lkrehi 5106 14 the the DT cord-335975-m6lkrehi 5106 15 diary diary NN cord-335975-m6lkrehi 5106 16 on on IN cord-335975-m6lkrehi 5106 17 prevalence prevalence NN cord-335975-m6lkrehi 5106 18 anxiety anxiety NN cord-335975-m6lkrehi 5106 19 , , , cord-335975-m6lkrehi 5106 20 depression depression NN cord-335975-m6lkrehi 5106 21 and and CC cord-335975-m6lkrehi 5106 22 post post JJ cord-335975-m6lkrehi 5106 23 traumatic traumatic JJ cord-335975-m6lkrehi 5106 24 disorders disorder NNS cord-335975-m6lkrehi 5106 25 during during IN cord-335975-m6lkrehi 5106 26 recovery recovery NN cord-335975-m6lkrehi 5106 27 . . . cord-335975-m6lkrehi 5107 1 Patients patient NNS cord-335975-m6lkrehi 5107 2 and and CC cord-335975-m6lkrehi 5107 3 methods method NNS cord-335975-m6lkrehi 5107 4 : : : cord-335975-m6lkrehi 5107 5 A a DT cord-335975-m6lkrehi 5107 6 structured structured JJ cord-335975-m6lkrehi 5107 7 interview interview NN cord-335975-m6lkrehi 5107 8 study study NN cord-335975-m6lkrehi 5107 9 was be VBD cord-335975-m6lkrehi 5107 10 administered administer VBN cord-335975-m6lkrehi 5107 11 to to TO cord-335975-m6lkrehi 5107 12 adult adult VB cord-335975-m6lkrehi 5107 13 critical critical JJ cord-335975-m6lkrehi 5107 14 illness illness NN cord-335975-m6lkrehi 5107 15 survivors survivor NNS cord-335975-m6lkrehi 5107 16 who who WP cord-335975-m6lkrehi 5107 17 received receive VBD cord-335975-m6lkrehi 5107 18 ≥ ≥ CD cord-335975-m6lkrehi 5107 19 48 48 CD cord-335975-m6lkrehi 5107 20 h h NN cord-335975-m6lkrehi 5107 21 of of IN cord-335975-m6lkrehi 5107 22 mechanical mechanical JJ cord-335975-m6lkrehi 5107 23 ventilation ventilation NN cord-335975-m6lkrehi 5107 24 in in IN cord-335975-m6lkrehi 5107 25 a a DT cord-335975-m6lkrehi 5107 26 medical medical JJ cord-335975-m6lkrehi 5107 27 and and CC cord-335975-m6lkrehi 5107 28 surgical surgical JJ cord-335975-m6lkrehi 5107 29 Intensive intensive JJ cord-335975-m6lkrehi 5107 30 care care NN cord-335975-m6lkrehi 5107 31 unit unit NN cord-335975-m6lkrehi 5107 32 . . . cord-335975-m6lkrehi 5108 1 After after IN cord-335975-m6lkrehi 5108 2 6 6 CD cord-335975-m6lkrehi 5108 3 months month NNS cord-335975-m6lkrehi 5108 4 , , , cord-335975-m6lkrehi 5108 5 this this DT cord-335975-m6lkrehi 5108 6 patients patient NNS cord-335975-m6lkrehi 5108 7 answered answer VBD cord-335975-m6lkrehi 5108 8 at at IN cord-335975-m6lkrehi 5108 9 two two CD cord-335975-m6lkrehi 5108 10 questionnaire questionnaire NN cord-335975-m6lkrehi 5108 11 - - HYPH cord-335975-m6lkrehi 5108 12 Hospital Hospital NNP cord-335975-m6lkrehi 5108 13 Anxiety Anxiety NNP cord-335975-m6lkrehi 5108 14 and and CC cord-335975-m6lkrehi 5108 15 Depression depression NN cord-335975-m6lkrehi 5108 16 Scale scale NN cord-335975-m6lkrehi 5108 17 ( ( -LRB- cord-335975-m6lkrehi 5108 18 HAD have VBD cord-335975-m6lkrehi 5108 19 ) ) -RRB- cord-335975-m6lkrehi 5108 20 and and CC cord-335975-m6lkrehi 5108 21 a a DT cord-335975-m6lkrehi 5108 22 screening screening NN cord-335975-m6lkrehi 5108 23 instrument instrument NN cord-335975-m6lkrehi 5108 24 for for IN cord-335975-m6lkrehi 5108 25 PTSD PTSD NNP cord-335975-m6lkrehi 5108 26 ( ( -LRB- cord-335975-m6lkrehi 5108 27 QSPT QSPT NNP cord-335975-m6lkrehi 5108 28 ) ) -RRB- cord-335975-m6lkrehi 5108 29 . . . cord-335975-m6lkrehi 5109 1 Results result NNS cord-335975-m6lkrehi 5109 2 : : : cord-335975-m6lkrehi 5110 1 From from IN cord-335975-m6lkrehi 5110 2 the the DT cord-335975-m6lkrehi 5110 3 survivors survivor NNS cord-335975-m6lkrehi 5110 4 at at IN cord-335975-m6lkrehi 5110 5 6 6 CD cord-335975-m6lkrehi 5110 6 months month NNS cord-335975-m6lkrehi 5110 7 , , , cord-335975-m6lkrehi 5110 8 36 36 CD cord-335975-m6lkrehi 5110 9 patients patient NNS cord-335975-m6lkrehi 5110 10 answered answer VBD cord-335975-m6lkrehi 5110 11 the the DT cord-335975-m6lkrehi 5110 12 questionnaires questionnaire NNS cord-335975-m6lkrehi 5110 13 . . . cord-335975-m6lkrehi 5111 1 We -PRON- PRP cord-335975-m6lkrehi 5111 2 have have VBP cord-335975-m6lkrehi 5111 3 two two CD cord-335975-m6lkrehi 5111 4 groups-18 groups-18 ADD cord-335975-m6lkrehi 5111 5 patients patient NNS cord-335975-m6lkrehi 5111 6 had have VBD cord-335975-m6lkrehi 5111 7 a a DT cord-335975-m6lkrehi 5111 8 diary diary NN cord-335975-m6lkrehi 5111 9 and and CC cord-335975-m6lkrehi 5111 10 18 18 CD cord-335975-m6lkrehi 5111 11 patients patient NNS cord-335975-m6lkrehi 5111 12 no no DT cord-335975-m6lkrehi 5111 13 diary diary NN cord-335975-m6lkrehi 5111 14 . . . cord-335975-m6lkrehi 5112 1 But but CC cord-335975-m6lkrehi 5112 2 these these DT cord-335975-m6lkrehi 5112 3 group group NN cord-335975-m6lkrehi 5112 4 are be VBP cord-335975-m6lkrehi 5112 5 so so RB cord-335975-m6lkrehi 5112 6 low low JJ cord-335975-m6lkrehi 5112 7 currently currently RB cord-335975-m6lkrehi 5112 8 to to TO cord-335975-m6lkrehi 5112 9 compare compare VB cord-335975-m6lkrehi 5112 10 Introduction introduction NN cord-335975-m6lkrehi 5112 11 : : : cord-335975-m6lkrehi 5112 12 In in IN cord-335975-m6lkrehi 5112 13 ARDS ARDS NNP cord-335975-m6lkrehi 5112 14 patients patient NNS cord-335975-m6lkrehi 5112 15 under under IN cord-335975-m6lkrehi 5112 16 ECMO ECMO NNP cord-335975-m6lkrehi 5112 17 common common JJ cord-335975-m6lkrehi 5112 18 ventilator ventilator NN cord-335975-m6lkrehi 5112 19 strategy strategy NN cord-335975-m6lkrehi 5112 20 aims aim VBZ cord-335975-m6lkrehi 5112 21 at at IN cord-335975-m6lkrehi 5112 22 resting rest VBG cord-335975-m6lkrehi 5112 23 the the DT cord-335975-m6lkrehi 5112 24 lung lung NN cord-335975-m6lkrehi 5112 25 by by IN cord-335975-m6lkrehi 5112 26 lowering lower VBG cord-335975-m6lkrehi 5112 27 tidal tidal JJ cord-335975-m6lkrehi 5112 28 volume volume NN cord-335975-m6lkrehi 5112 29 ( ( -LRB- cord-335975-m6lkrehi 5112 30 VT VT NNP cord-335975-m6lkrehi 5112 31 ) ) -RRB- cord-335975-m6lkrehi 5112 32 in in IN cord-335975-m6lkrehi 5112 33 the the DT cord-335975-m6lkrehi 5112 34 1 1 CD cord-335975-m6lkrehi 5112 35 - - SYM cord-335975-m6lkrehi 5112 36 4 4 CD cord-335975-m6lkrehi 5112 37 ml ml NN cord-335975-m6lkrehi 5112 38 kg kg NNP cord-335975-m6lkrehi 5112 39 predicted predict VBD cord-335975-m6lkrehi 5112 40 body body NN cord-335975-m6lkrehi 5112 41 weight weight NN cord-335975-m6lkrehi 5112 42 range range NN cord-335975-m6lkrehi 5112 43 found find VBN cord-335975-m6lkrehi 5112 44 in in IN cord-335975-m6lkrehi 5112 45 the the DT cord-335975-m6lkrehi 5112 46 literature literature NN cord-335975-m6lkrehi 5112 47 analysis analysis NN cord-335975-m6lkrehi 5112 48 . . . cord-335975-m6lkrehi 5113 1 We -PRON- PRP cord-335975-m6lkrehi 5113 2 tested test VBD cord-335975-m6lkrehi 5113 3 on on IN cord-335975-m6lkrehi 5113 4 the the DT cord-335975-m6lkrehi 5113 5 bench bench NN cord-335975-m6lkrehi 5114 1 the the DT cord-335975-m6lkrehi 5114 2 not not RB cord-335975-m6lkrehi 5114 3 previously previously RB cord-335975-m6lkrehi 5114 4 explored explore VBN cord-335975-m6lkrehi 5114 5 hypothesis hypothesis NN cord-335975-m6lkrehi 5114 6 that that IN cord-335975-m6lkrehi 5114 7 VT VT NNP cord-335975-m6lkrehi 5114 8 was be VBD cord-335975-m6lkrehi 5114 9 not not RB cord-335975-m6lkrehi 5114 10 delivered deliver VBN cord-335975-m6lkrehi 5114 11 in in IN cord-335975-m6lkrehi 5114 12 the the DT cord-335975-m6lkrehi 5114 13 10 10 CD cord-335975-m6lkrehi 5114 14 % % NN cord-335975-m6lkrehi 5114 15 accuracy accuracy NN cord-335975-m6lkrehi 5114 16 by by IN cord-335975-m6lkrehi 5114 17 most most JJS cord-335975-m6lkrehi 5114 18 of of IN cord-335975-m6lkrehi 5114 19 ICU ICU NNP cord-335975-m6lkrehi 5114 20 ventilators ventilator NNS cord-335975-m6lkrehi 5114 21 in in IN cord-335975-m6lkrehi 5114 22 this this DT cord-335975-m6lkrehi 5114 23 low low JJ cord-335975-m6lkrehi 5114 24 range range NN cord-335975-m6lkrehi 5114 25 . . . cord-335975-m6lkrehi 5115 1 Patients patient NNS cord-335975-m6lkrehi 5115 2 and and CC cord-335975-m6lkrehi 5115 3 methods method NNS cord-335975-m6lkrehi 5115 4 : : : cord-335975-m6lkrehi 5115 5 Pneumatic pneumatic JJ cord-335975-m6lkrehi 5115 6 test test NN cord-335975-m6lkrehi 5115 7 lung lung NN cord-335975-m6lkrehi 5115 8 set set VBN cord-335975-m6lkrehi 5115 9 at at IN cord-335975-m6lkrehi 5115 10 20 20 CD cord-335975-m6lkrehi 5115 11 ml ml NN cord-335975-m6lkrehi 5115 12 / / SYM cord-335975-m6lkrehi 5115 13 cmH2O cmH2O NNP cord-335975-m6lkrehi 5115 14 compliance compliance NN cord-335975-m6lkrehi 5115 15 and and CC cord-335975-m6lkrehi 5115 16 20 20 CD cord-335975-m6lkrehi 5115 17 cm cm NN cord-335975-m6lkrehi 5115 18 H h NN cord-335975-m6lkrehi 5116 1 2 2 LS cord-335975-m6lkrehi 5116 2 O o NN cord-335975-m6lkrehi 5116 3 / / SYM cord-335975-m6lkrehi 5116 4 L l NN cord-335975-m6lkrehi 5116 5 / / SYM cord-335975-m6lkrehi 5116 6 s s POS cord-335975-m6lkrehi 5116 7 resistance resistance NN cord-335975-m6lkrehi 5116 8 was be VBD cord-335975-m6lkrehi 5116 9 attached attach VBN cord-335975-m6lkrehi 5116 10 to to IN cord-335975-m6lkrehi 5116 11 any any DT cord-335975-m6lkrehi 5116 12 of of IN cord-335975-m6lkrehi 5116 13 5 5 CD cord-335975-m6lkrehi 5116 14 ICU ICU NNP cord-335975-m6lkrehi 5116 15 ventilators ventilator NNS cord-335975-m6lkrehi 5116 16 ( ( -LRB- cord-335975-m6lkrehi 5116 17 V v NN cord-335975-m6lkrehi 5116 18 500 500 CD cord-335975-m6lkrehi 5116 19 ( ( -LRB- cord-335975-m6lkrehi 5116 20 Drager Drager NNP cord-335975-m6lkrehi 5116 21 ) ) -RRB- cord-335975-m6lkrehi 5116 22 , , , cord-335975-m6lkrehi 5116 23 Carescape Carescape NNP cord-335975-m6lkrehi 5116 24 R R NNP cord-335975-m6lkrehi 5116 25 860 860 CD cord-335975-m6lkrehi 5116 26 ( ( -LRB- cord-335975-m6lkrehi 5116 27 GE GE NNP cord-335975-m6lkrehi 5116 28 Healthcare Healthcare NNP cord-335975-m6lkrehi 5116 29 ) ) -RRB- cord-335975-m6lkrehi 5116 30 , , , cord-335975-m6lkrehi 5116 31 Servo Servo NNP cord-335975-m6lkrehi 5116 32 U U NNP cord-335975-m6lkrehi 5116 33 ( ( -LRB- cord-335975-m6lkrehi 5116 34 Maquet Maquet NNP cord-335975-m6lkrehi 5116 35 ) ) -RRB- cord-335975-m6lkrehi 5116 36 , , , cord-335975-m6lkrehi 5116 37 PB980 PB980 NNP cord-335975-m6lkrehi 5116 38 ( ( -LRB- cord-335975-m6lkrehi 5116 39 Covidien Covidien NNP cord-335975-m6lkrehi 5116 40 ) ) -RRB- cord-335975-m6lkrehi 5116 41 and and CC cord-335975-m6lkrehi 5116 42 G5 G5 NNP cord-335975-m6lkrehi 5116 43 ( ( -LRB- cord-335975-m6lkrehi 5116 44 Hamilton Hamilton NNP cord-335975-m6lkrehi 5116 45 ) ) -RRB- cord-335975-m6lkrehi 5116 46 ) ) -RRB- cord-335975-m6lkrehi 5116 47 equipped equip VBN cord-335975-m6lkrehi 5116 48 with with IN cord-335975-m6lkrehi 5116 49 Heated heated JJ cord-335975-m6lkrehi 5116 50 humidifier humidifier NN cord-335975-m6lkrehi 5116 51 ( ( -LRB- cord-335975-m6lkrehi 5116 52 Fisher Fisher NNP cord-335975-m6lkrehi 5116 53 - - HYPH cord-335975-m6lkrehi 5116 54 Paykel Paykel NNP cord-335975-m6lkrehi 5116 55 MR MR NNP cord-335975-m6lkrehi 5116 56 850 850 CD cord-335975-m6lkrehi 5116 57 ) ) -RRB- cord-335975-m6lkrehi 5116 58 set set VBD cord-335975-m6lkrehi 5116 59 off off RP cord-335975-m6lkrehi 5116 60 and and CC cord-335975-m6lkrehi 5116 61 adult adult NN cord-335975-m6lkrehi 5116 62 ventilator ventilator NN cord-335975-m6lkrehi 5116 63 circuit circuit NN cord-335975-m6lkrehi 5116 64 ( ( -LRB- cord-335975-m6lkrehi 5116 65 RT RT NNP cord-335975-m6lkrehi 5116 66 380 380 CD cord-335975-m6lkrehi 5116 67 EVAQUA EVAQUA NNP cord-335975-m6lkrehi 5116 68 Fisher Fisher NNP cord-335975-m6lkrehi 5116 69 Paykel Paykel NNP cord-335975-m6lkrehi 5116 70 ) ) -RRB- cord-335975-m6lkrehi 5116 71 . . . cord-335975-m6lkrehi 5117 1 Each each DT cord-335975-m6lkrehi 5117 2 ICU ICU NNP cord-335975-m6lkrehi 5117 3 ventilator ventilator NN cord-335975-m6lkrehi 5117 4 was be VBD cord-335975-m6lkrehi 5117 5 set set VBN cord-335975-m6lkrehi 5117 6 in in IN cord-335975-m6lkrehi 5117 7 BTPS BTPS NNP cord-335975-m6lkrehi 5117 8 condition condition NN cord-335975-m6lkrehi 5117 9 , , , cord-335975-m6lkrehi 5117 10 at at IN cord-335975-m6lkrehi 5117 11 PEEP peep NN cord-335975-m6lkrehi 5117 12 12 12 CD cord-335975-m6lkrehi 5117 13 cm cm NNS cord-335975-m6lkrehi 5118 1 H h NN cord-335975-m6lkrehi 5119 1 2 2 LS cord-335975-m6lkrehi 5119 2 O o UH cord-335975-m6lkrehi 5119 3 and and CC cord-335975-m6lkrehi 5119 4 FIO2 FIO2 NNP cord-335975-m6lkrehi 5119 5 0.21 0.21 CD cord-335975-m6lkrehi 5119 6 . . . cord-335975-m6lkrehi 5120 1 Airway airway JJ cord-335975-m6lkrehi 5120 2 pressure pressure NN cord-335975-m6lkrehi 5120 3 and and CC cord-335975-m6lkrehi 5120 4 airflow airflow NN cord-335975-m6lkrehi 5121 1 ( ( -LRB- cord-335975-m6lkrehi 5121 2 Hans Hans NNP cord-335975-m6lkrehi 5121 3 - - HYPH cord-335975-m6lkrehi 5121 4 Rudolph Rudolph NNP cord-335975-m6lkrehi 5121 5 pneumotachograph pneumotachograph NN cord-335975-m6lkrehi 5121 6 ) ) -RRB- cord-335975-m6lkrehi 5121 7 were be VBD cord-335975-m6lkrehi 5121 8 measured measure VBN cord-335975-m6lkrehi 5121 9 ( ( -LRB- cord-335975-m6lkrehi 5121 10 Biopac Biopac NNP cord-335975-m6lkrehi 5121 11 M150 M150 NNP cord-335975-m6lkrehi 5121 12 ) ) -RRB- cord-335975-m6lkrehi 5122 1 proximal proximal JJ cord-335975-m6lkrehi 5122 2 to to IN cord-335975-m6lkrehi 5122 3 the the DT cord-335975-m6lkrehi 5122 4 lung lung NN cord-335975-m6lkrehi 5122 5 model model NN cord-335975-m6lkrehi 5122 6 . . . cord-335975-m6lkrehi 5123 1 For for IN cord-335975-m6lkrehi 5123 2 each each DT cord-335975-m6lkrehi 5123 3 ventilator ventilator NN cord-335975-m6lkrehi 5123 4 a a DT cord-335975-m6lkrehi 5123 5 series series NN cord-335975-m6lkrehi 5123 6 of of IN cord-335975-m6lkrehi 5123 7 VT VT NNP cord-335975-m6lkrehi 5123 8 ranging range VBG cord-335975-m6lkrehi 5123 9 from from IN cord-335975-m6lkrehi 5123 10 100 100 CD cord-335975-m6lkrehi 5123 11 to to TO cord-335975-m6lkrehi 5123 12 280 280 CD cord-335975-m6lkrehi 5123 13 ml ml NNS cord-335975-m6lkrehi 5123 14 was be VBD cord-335975-m6lkrehi 5123 15 delivered deliver VBN cord-335975-m6lkrehi 5123 16 for for IN cord-335975-m6lkrehi 5123 17 10 10 CD cord-335975-m6lkrehi 5123 18 breaths breath NNS cord-335975-m6lkrehi 5123 19 each each DT cord-335975-m6lkrehi 5123 20 , , , cord-335975-m6lkrehi 5123 21 at at IN cord-335975-m6lkrehi 5123 22 30 30 CD cord-335975-m6lkrehi 5123 23 then then RB cord-335975-m6lkrehi 5123 24 at at IN cord-335975-m6lkrehi 5123 25 15 15 CD cord-335975-m6lkrehi 5123 26 breaths breath NNS cord-335975-m6lkrehi 5123 27 / / SYM cord-335975-m6lkrehi 5123 28 min min NN cord-335975-m6lkrehi 5123 29 respiratory respiratory JJ cord-335975-m6lkrehi 5123 30 rate rate NN cord-335975-m6lkrehi 5123 31 ( ( -LRB- cord-335975-m6lkrehi 5123 32 RR rr NN cord-335975-m6lkrehi 5123 33 ) ) -RRB- cord-335975-m6lkrehi 5123 34 . . . cord-335975-m6lkrehi 5124 1 The the DT cord-335975-m6lkrehi 5124 2 relationship relationship NN cord-335975-m6lkrehi 5124 3 of of IN cord-335975-m6lkrehi 5124 4 VT VT NNP cord-335975-m6lkrehi 5124 5 measured measure VBN cord-335975-m6lkrehi 5124 6 to to IN cord-335975-m6lkrehi 5124 7 VT VT NNP cord-335975-m6lkrehi 5124 8 set set NNP cord-335975-m6lkrehi 5124 9 was be VBD cord-335975-m6lkrehi 5124 10 assessed assess VBN cord-335975-m6lkrehi 5124 11 by by IN cord-335975-m6lkrehi 5124 12 linear linear JJ cord-335975-m6lkrehi 5124 13 regression regression NN cord-335975-m6lkrehi 5124 14 over over IN cord-335975-m6lkrehi 5124 15 the the DT cord-335975-m6lkrehi 5124 16 5 5 CD cord-335975-m6lkrehi 5124 17 ICU ICU NNP cord-335975-m6lkrehi 5124 18 ventilators ventilator NNS cord-335975-m6lkrehi 5124 19 for for IN cord-335975-m6lkrehi 5124 20 each each DT cord-335975-m6lkrehi 5124 21 circuit circuit NN cord-335975-m6lkrehi 5124 22 - - HYPH cord-335975-m6lkrehi 5124 23 RR rr NN cord-335975-m6lkrehi 5124 24 combination combination NN cord-335975-m6lkrehi 5124 25 . . . cord-335975-m6lkrehi 5125 1 In in IN cord-335975-m6lkrehi 5125 2 each each DT cord-335975-m6lkrehi 5125 3 model model NN cord-335975-m6lkrehi 5125 4 , , , cord-335975-m6lkrehi 5125 5 the the DT cord-335975-m6lkrehi 5125 6 change change NN cord-335975-m6lkrehi 5125 7 from from IN cord-335975-m6lkrehi 5125 8 the the DT cord-335975-m6lkrehi 5125 9 mean mean JJ cord-335975-m6lkrehi 5125 10 effect effect NN cord-335975-m6lkrehi 5125 11 was be VBD cord-335975-m6lkrehi 5125 12 assessed assess VBN cord-335975-m6lkrehi 5125 13 for for IN cord-335975-m6lkrehi 5125 14 each each DT cord-335975-m6lkrehi 5125 15 ventilator ventilator NN cord-335975-m6lkrehi 5125 16 . . . cord-335975-m6lkrehi 5126 1 For for IN cord-335975-m6lkrehi 5126 2 each each DT cord-335975-m6lkrehi 5126 3 model model NN cord-335975-m6lkrehi 5126 4 we -PRON- PRP cord-335975-m6lkrehi 5126 5 obtained obtain VBD cord-335975-m6lkrehi 5126 6 the the DT cord-335975-m6lkrehi 5126 7 mean mean JJ cord-335975-m6lkrehi 5126 8 effect effect NN cord-335975-m6lkrehi 5126 9 of of IN cord-335975-m6lkrehi 5126 10 the the DT cord-335975-m6lkrehi 5126 11 5 5 CD cord-335975-m6lkrehi 5126 12 ventilators ventilator NNS cord-335975-m6lkrehi 5127 1 then then RB cord-335975-m6lkrehi 5127 2 we -PRON- PRP cord-335975-m6lkrehi 5127 3 compared compare VBD cord-335975-m6lkrehi 5127 4 the the DT cord-335975-m6lkrehi 5127 5 effect effect NN cord-335975-m6lkrehi 5127 6 of of IN cord-335975-m6lkrehi 5127 7 each each DT cord-335975-m6lkrehi 5127 8 ventilator ventilator NN cord-335975-m6lkrehi 5127 9 to to IN cord-335975-m6lkrehi 5127 10 the the DT cord-335975-m6lkrehi 5127 11 mean mean JJ cord-335975-m6lkrehi 5127 12 effect effect NN cord-335975-m6lkrehi 5127 13 . . . cord-335975-m6lkrehi 5128 1 Results result NNS cord-335975-m6lkrehi 5128 2 : : : cord-335975-m6lkrehi 5129 1 For for IN cord-335975-m6lkrehi 5129 2 each each DT cord-335975-m6lkrehi 5129 3 combination combination NN cord-335975-m6lkrehi 5129 4 of of IN cord-335975-m6lkrehi 5129 5 f f NNP cord-335975-m6lkrehi 5129 6 and and CC cord-335975-m6lkrehi 5129 7 circuit circuit NNP cord-335975-m6lkrehi 5129 8 , , , cord-335975-m6lkrehi 5129 9 the the DT cord-335975-m6lkrehi 5129 10 mean mean JJ cord-335975-m6lkrehi 5129 11 slope slope NN cord-335975-m6lkrehi 5129 12 was be VBD cord-335975-m6lkrehi 5129 13 significantly significantly RB cord-335975-m6lkrehi 5129 14 lower low JJR cord-335975-m6lkrehi 5129 15 than than IN cord-335975-m6lkrehi 5129 16 1 1 CD cord-335975-m6lkrehi 5129 17 indicating indicate VBG cord-335975-m6lkrehi 5129 18 that that IN cord-335975-m6lkrehi 5129 19 , , , cord-335975-m6lkrehi 5129 20 on on IN cord-335975-m6lkrehi 5129 21 average average JJ cord-335975-m6lkrehi 5129 22 , , , cord-335975-m6lkrehi 5129 23 the the DT cord-335975-m6lkrehi 5129 24 set set NN cord-335975-m6lkrehi 5129 25 VT VT NNP cord-335975-m6lkrehi 5129 26 was be VBD cord-335975-m6lkrehi 5129 27 under under IN cord-335975-m6lkrehi 5129 28 delivered deliver VBN cord-335975-m6lkrehi 5129 29 ( ( -LRB- cord-335975-m6lkrehi 5129 30 Table table NN cord-335975-m6lkrehi 5129 31 ) ) -RRB- cord-335975-m6lkrehi 5129 32 . . . cord-335975-m6lkrehi 5130 1 There there EX cord-335975-m6lkrehi 5130 2 were be VBD cord-335975-m6lkrehi 5130 3 differences difference NNS cord-335975-m6lkrehi 5130 4 in in IN cord-335975-m6lkrehi 5130 5 change change NN cord-335975-m6lkrehi 5130 6 in in IN cord-335975-m6lkrehi 5130 7 slope slope NN cord-335975-m6lkrehi 5130 8 from from IN cord-335975-m6lkrehi 5130 9 the the DT cord-335975-m6lkrehi 5130 10 mean mean NN cord-335975-m6lkrehi 5130 11 across across IN cord-335975-m6lkrehi 5130 12 the the DT cord-335975-m6lkrehi 5130 13 ventilators ventilator NNS cord-335975-m6lkrehi 5130 14 with with IN cord-335975-m6lkrehi 5130 15 interaction interaction NN cord-335975-m6lkrehi 5130 16 between between IN cord-335975-m6lkrehi 5130 17 ventilators ventilator NNS cord-335975-m6lkrehi 5130 18 and and CC cord-335975-m6lkrehi 5130 19 combinations combination NNS cord-335975-m6lkrehi 5130 20 . . . cord-335975-m6lkrehi 5131 1 As as IN cord-335975-m6lkrehi 5131 2 an an DT cord-335975-m6lkrehi 5131 3 example example NN cord-335975-m6lkrehi 5131 4 , , , cord-335975-m6lkrehi 5131 5 for for IN cord-335975-m6lkrehi 5131 6 the the DT cord-335975-m6lkrehi 5131 7 adult adult NN cord-335975-m6lkrehi 5131 8 circuit circuit NNP cord-335975-m6lkrehi 5131 9 f f NNP cord-335975-m6lkrehi 5131 10 15 15 CD cord-335975-m6lkrehi 5131 11 , , , cord-335975-m6lkrehi 5131 12 Carestation Carestation NNP cord-335975-m6lkrehi 5131 13 , , , cord-335975-m6lkrehi 5131 14 PB980 PB980 NNP cord-335975-m6lkrehi 5131 15 and and CC cord-335975-m6lkrehi 5131 16 Servo Servo NNP cord-335975-m6lkrehi 5131 17 U U NNP cord-335975-m6lkrehi 5131 18 performed perform VBD cord-335975-m6lkrehi 5131 19 better well RBR cord-335975-m6lkrehi 5131 20 than than IN cord-335975-m6lkrehi 5131 21 G5 G5 NNP cord-335975-m6lkrehi 5131 22 and and CC cord-335975-m6lkrehi 5131 23 V500 V500 NNP cord-335975-m6lkrehi 5131 24 . . . cord-335975-m6lkrehi 5132 1 Across across IN cord-335975-m6lkrehi 5132 2 the the DT cord-335975-m6lkrehi 5132 3 combinations combination NNS cord-335975-m6lkrehi 5132 4 , , , cord-335975-m6lkrehi 5132 5 V500 V500 NNP cord-335975-m6lkrehi 5132 6 had have VBD cord-335975-m6lkrehi 5132 7 consistent consistent JJ cord-335975-m6lkrehi 5132 8 negative negative JJ cord-335975-m6lkrehi 5132 9 ( ( -LRB- cord-335975-m6lkrehi 5132 10 greater great JJR cord-335975-m6lkrehi 5132 11 underestimation underestimation NN cord-335975-m6lkrehi 5132 12 than than IN cord-335975-m6lkrehi 5132 13 average average JJ cord-335975-m6lkrehi 5132 14 ) ) -RRB- cord-335975-m6lkrehi 5132 15 slopes slope NNS cord-335975-m6lkrehi 5132 16 and and CC cord-335975-m6lkrehi 5132 17 Servo Servo NNP cord-335975-m6lkrehi 5132 18 U U NNP cord-335975-m6lkrehi 5132 19 consistent consistent JJ cord-335975-m6lkrehi 5132 20 positive positive JJ cord-335975-m6lkrehi 5132 21 ( ( -LRB- cord-335975-m6lkrehi 5132 22 lower low JJR cord-335975-m6lkrehi 5132 23 underestimation underestimation NN cord-335975-m6lkrehi 5132 24 than than IN cord-335975-m6lkrehi 5132 25 average average JJ cord-335975-m6lkrehi 5132 26 ) ) -RRB- cord-335975-m6lkrehi 5132 27 slopes slope NNS cord-335975-m6lkrehi 5132 28 whilst whilst IN cord-335975-m6lkrehi 5132 29 the the DT cord-335975-m6lkrehi 5132 30 slope slope NN cord-335975-m6lkrehi 5132 31 sign sign NN cord-335975-m6lkrehi 5132 32 in in IN cord-335975-m6lkrehi 5132 33 the the DT cord-335975-m6lkrehi 5132 34 three three CD cord-335975-m6lkrehi 5132 35 others other NNS cord-335975-m6lkrehi 5132 36 changed change VBD cord-335975-m6lkrehi 5132 37 direction direction NN cord-335975-m6lkrehi 5132 38 . . . cord-335975-m6lkrehi 5133 1 biomarkers biomarker NNS cord-335975-m6lkrehi 5133 2 . . . cord-335975-m6lkrehi 5134 1 Yet yet RB cord-335975-m6lkrehi 5134 2 , , , cord-335975-m6lkrehi 5134 3 HLA HLA NNP cord-335975-m6lkrehi 5134 4 - - HYPH cord-335975-m6lkrehi 5134 5 DR DR NNP cord-335975-m6lkrehi 5134 6 expression expression NN cord-335975-m6lkrehi 5134 7 on on IN cord-335975-m6lkrehi 5134 8 alveolar alveolar NN cord-335975-m6lkrehi 5134 9 monocytes monocyte NNS cord-335975-m6lkrehi 5134 10 was be VBD cord-335975-m6lkrehi 5134 11 lower low JJR cord-335975-m6lkrehi 5134 12 in in IN cord-335975-m6lkrehi 5134 13 ARDS ARDS NNP cord-335975-m6lkrehi 5134 14 than than IN cord-335975-m6lkrehi 5134 15 in in IN cord-335975-m6lkrehi 5134 16 controls control NNS cord-335975-m6lkrehi 5134 17 , , , cord-335975-m6lkrehi 5134 18 consistent consistent JJ cord-335975-m6lkrehi 5134 19 with with IN cord-335975-m6lkrehi 5134 20 sepsis sepsis NN cord-335975-m6lkrehi 5134 21 - - HYPH cord-335975-m6lkrehi 5134 22 induced induce VBN cord-335975-m6lkrehi 5134 23 immunosuppression immunosuppression NN cord-335975-m6lkrehi 5134 24 at at IN cord-335975-m6lkrehi 5134 25 the the DT cord-335975-m6lkrehi 5134 26 alveolar alveolar JJ cord-335975-m6lkrehi 5134 27 level level NN cord-335975-m6lkrehi 5134 28 . . . cord-335975-m6lkrehi 5135 1 Functional functional JJ cord-335975-m6lkrehi 5135 2 differences difference NNS cord-335975-m6lkrehi 5135 3 observed observe VBD cord-335975-m6lkrehi 5135 4 between between IN cord-335975-m6lkrehi 5135 5 ARDS ARDS NNP cord-335975-m6lkrehi 5135 6 and and CC cord-335975-m6lkrehi 5135 7 controls control NNS cord-335975-m6lkrehi 5135 8 suggested suggest VBD cord-335975-m6lkrehi 5135 9 a a DT cord-335975-m6lkrehi 5135 10 tolerogenic tolerogenic JJ cord-335975-m6lkrehi 5135 11 profile profile NN cord-335975-m6lkrehi 5135 12 of of IN cord-335975-m6lkrehi 5135 13 ARDS ARDS NNP cord-335975-m6lkrehi 5135 14 monocytes monocyte NNS cord-335975-m6lkrehi 5135 15 . . . cord-335975-m6lkrehi 5136 1 Introduction introduction NN cord-335975-m6lkrehi 5136 2 : : : cord-335975-m6lkrehi 5137 1 Despite despite IN cord-335975-m6lkrehi 5137 2 their -PRON- PRP$ cord-335975-m6lkrehi 5137 3 recommendation recommendation NN cord-335975-m6lkrehi 5137 4 in in IN cord-335975-m6lkrehi 5137 5 the the DT cord-335975-m6lkrehi 5137 6 prevention prevention NN cord-335975-m6lkrehi 5137 7 of of IN cord-335975-m6lkrehi 5137 8 ventilator ventilator NN cord-335975-m6lkrehi 5137 9 - - HYPH cord-335975-m6lkrehi 5137 10 associated associate VBN cord-335975-m6lkrehi 5137 11 pneumonia pneumonia NN cord-335975-m6lkrehi 5137 12 , , , cord-335975-m6lkrehi 5137 13 oral oral JJ cord-335975-m6lkrehi 5137 14 care care NN cord-335975-m6lkrehi 5137 15 is be VBZ cord-335975-m6lkrehi 5137 16 not not RB cord-335975-m6lkrehi 5137 17 still still RB cord-335975-m6lkrehi 5137 18 clearly clearly RB cord-335975-m6lkrehi 5137 19 standardized standardize VBN cord-335975-m6lkrehi 5137 20 . . . cord-335975-m6lkrehi 5138 1 It -PRON- PRP cord-335975-m6lkrehi 5138 2 generally generally RB cord-335975-m6lkrehi 5138 3 includes include VBZ cord-335975-m6lkrehi 5138 4 a a DT cord-335975-m6lkrehi 5138 5 time time NN cord-335975-m6lkrehi 5138 6 for for IN cord-335975-m6lkrehi 5138 7 oropharyngeal oropharyngeal JJ cord-335975-m6lkrehi 5138 8 and and CC cord-335975-m6lkrehi 5138 9 tracheal tracheal JJ cord-335975-m6lkrehi 5138 10 suctions suction NNS cord-335975-m6lkrehi 5138 11 which which WDT cord-335975-m6lkrehi 5138 12 can can MD cord-335975-m6lkrehi 5138 13 induce induce VB cord-335975-m6lkrehi 5138 14 a a DT cord-335975-m6lkrehi 5138 15 cough cough NN cord-335975-m6lkrehi 5138 16 reflex reflex NN cord-335975-m6lkrehi 5138 17 in in IN cord-335975-m6lkrehi 5138 18 non non JJ cord-335975-m6lkrehi 5138 19 - - JJ cord-335975-m6lkrehi 5138 20 paralyzed paralyzed JJ cord-335975-m6lkrehi 5138 21 patients patient NNS cord-335975-m6lkrehi 5138 22 leading lead VBG cord-335975-m6lkrehi 5138 23 to to IN cord-335975-m6lkrehi 5138 24 the the DT cord-335975-m6lkrehi 5138 25 mobilization mobilization NN cord-335975-m6lkrehi 5138 26 of of IN cord-335975-m6lkrehi 5138 27 the the DT cord-335975-m6lkrehi 5138 28 endotracheal endotracheal NN cord-335975-m6lkrehi 5138 29 tube tube NN cord-335975-m6lkrehi 5138 30 and and CC cord-335975-m6lkrehi 5138 31 a a DT cord-335975-m6lkrehi 5138 32 consecutively consecutively RB cord-335975-m6lkrehi 5138 33 increased increase VBN cord-335975-m6lkrehi 5138 34 risk risk NN cord-335975-m6lkrehi 5138 35 of of IN cord-335975-m6lkrehi 5138 36 tracheal tracheal JJ cord-335975-m6lkrehi 5138 37 microaspirations microaspiration NNS cord-335975-m6lkrehi 5138 38 . . . cord-335975-m6lkrehi 5139 1 During during IN cord-335975-m6lkrehi 5139 2 the the DT cord-335975-m6lkrehi 5139 3 oral oral JJ cord-335975-m6lkrehi 5139 4 care care NN cord-335975-m6lkrehi 5139 5 procedure procedure NN cord-335975-m6lkrehi 5139 6 , , , cord-335975-m6lkrehi 5139 7 drainage drainage NN cord-335975-m6lkrehi 5139 8 of of IN cord-335975-m6lkrehi 5139 9 subglottic subglottic JJ cord-335975-m6lkrehi 5139 10 secretions secretion NNS cord-335975-m6lkrehi 5139 11 at at IN cord-335975-m6lkrehi 5139 12 particular particular JJ cord-335975-m6lkrehi 5139 13 times time NNS cord-335975-m6lkrehi 5139 14 before before IN cord-335975-m6lkrehi 5139 15 oro oro NNP cord-335975-m6lkrehi 5139 16 - - HYPH cord-335975-m6lkrehi 5139 17 tracheal tracheal JJ cord-335975-m6lkrehi 5139 18 suctions suction NNS cord-335975-m6lkrehi 5139 19 is be VBZ cord-335975-m6lkrehi 5139 20 expected expect VBN cord-335975-m6lkrehi 5139 21 to to TO cord-335975-m6lkrehi 5139 22 reduce reduce VB cord-335975-m6lkrehi 5139 23 microaspiration microaspiration NN cord-335975-m6lkrehi 5139 24 . . . cord-335975-m6lkrehi 5140 1 The the DT cord-335975-m6lkrehi 5140 2 aim aim NN cord-335975-m6lkrehi 5140 3 of of IN cord-335975-m6lkrehi 5140 4 this this DT cord-335975-m6lkrehi 5140 5 study study NN cord-335975-m6lkrehi 5140 6 is be VBZ cord-335975-m6lkrehi 5140 7 to to TO cord-335975-m6lkrehi 5140 8 assess assess VB cord-335975-m6lkrehi 5140 9 whether whether IN cord-335975-m6lkrehi 5140 10 this this DT cord-335975-m6lkrehi 5140 11 " " `` cord-335975-m6lkrehi 5140 12 optimized optimize VBN cord-335975-m6lkrehi 5140 13 " " '' cord-335975-m6lkrehi 5140 14 oral oral JJ cord-335975-m6lkrehi 5140 15 care care NN cord-335975-m6lkrehi 5140 16 including include VBG cord-335975-m6lkrehi 5140 17 subglottic subglottic JJ cord-335975-m6lkrehi 5140 18 drainage drainage NN cord-335975-m6lkrehi 5140 19 can can MD cord-335975-m6lkrehi 5140 20 reduce reduce VB cord-335975-m6lkrehi 5140 21 microaspirations microaspiration NNS cord-335975-m6lkrehi 5140 22 . . . cord-335975-m6lkrehi 5141 1 This this DT cord-335975-m6lkrehi 5141 2 is be VBZ cord-335975-m6lkrehi 5141 3 an an DT cord-335975-m6lkrehi 5141 4 open open JJ cord-335975-m6lkrehi 5141 5 prospective prospective JJ cord-335975-m6lkrehi 5141 6 study study NN cord-335975-m6lkrehi 5141 7 , , , cord-335975-m6lkrehi 5141 8 including include VBG cord-335975-m6lkrehi 5141 9 ICU ICU NNP cord-335975-m6lkrehi 5141 10 ventilated ventilate VBN cord-335975-m6lkrehi 5141 11 patients patient NNS cord-335975-m6lkrehi 5141 12 . . . cord-335975-m6lkrehi 5142 1 Two two CD cord-335975-m6lkrehi 5142 2 procedures procedure NNS cord-335975-m6lkrehi 5142 3 have have VBP cord-335975-m6lkrehi 5142 4 been be VBN cord-335975-m6lkrehi 5142 5 compared compare VBN cord-335975-m6lkrehi 5142 6 in in IN cord-335975-m6lkrehi 5142 7 two two CD cord-335975-m6lkrehi 5142 8 randomized randomized JJ cord-335975-m6lkrehi 5142 9 cross cross NN cord-335975-m6lkrehi 5142 10 - - HYPH cord-335975-m6lkrehi 5142 11 over over RP cord-335975-m6lkrehi 5142 12 consecutive consecutive JJ cord-335975-m6lkrehi 5142 13 periods period NNS cord-335975-m6lkrehi 5142 14 of of IN cord-335975-m6lkrehi 5142 15 one one CD cord-335975-m6lkrehi 5142 16 day day NN cord-335975-m6lkrehi 5142 17 each each DT cord-335975-m6lkrehi 5142 18 ( ( -LRB- cord-335975-m6lkrehi 5142 19 3 3 CD cord-335975-m6lkrehi 5142 20 oral oral JJ cord-335975-m6lkrehi 5142 21 cares care VBZ cord-335975-m6lkrehi 5142 22 a a DT cord-335975-m6lkrehi 5142 23 day)-on day)-on NNP cord-335975-m6lkrehi 5142 24 1 1 CD cord-335975-m6lkrehi 5142 25 day day NN cord-335975-m6lkrehi 5142 26 , , , cord-335975-m6lkrehi 5142 27 they -PRON- PRP cord-335975-m6lkrehi 5142 28 received receive VBD cord-335975-m6lkrehi 5142 29 routine routine JJ cord-335975-m6lkrehi 5142 30 oral oral JJ cord-335975-m6lkrehi 5142 31 care care NN cord-335975-m6lkrehi 5142 32 ( ( -LRB- cord-335975-m6lkrehi 5142 33 oral oral JJ cord-335975-m6lkrehi 5142 34 care care NN cord-335975-m6lkrehi 5142 35 ( ( -LRB- cord-335975-m6lkrehi 5142 36 O o UH cord-335975-m6lkrehi 5142 37 ) ) -RRB- cord-335975-m6lkrehi 5142 38 then then RB cord-335975-m6lkrehi 5142 39 tracheal tracheal JJ cord-335975-m6lkrehi 5142 40 suction suction NN cord-335975-m6lkrehi 5142 41 ( ( -LRB- cord-335975-m6lkrehi 5142 42 T T NNP cord-335975-m6lkrehi 5142 43 ) ) -RRB- cord-335975-m6lkrehi 5142 44 ) ) -RRB- cord-335975-m6lkrehi 5142 45 and and CC cord-335975-m6lkrehi 5142 46 on on IN cord-335975-m6lkrehi 5142 47 the the DT cord-335975-m6lkrehi 5142 48 other other JJ cord-335975-m6lkrehi 5142 49 day day NN cord-335975-m6lkrehi 5142 50 they -PRON- PRP cord-335975-m6lkrehi 5142 51 received receive VBD cord-335975-m6lkrehi 5142 52 optimized optimize VBN cord-335975-m6lkrehi 5142 53 oral oral JJ cord-335975-m6lkrehi 5142 54 care care NN cord-335975-m6lkrehi 5142 55 ( ( -LRB- cord-335975-m6lkrehi 5142 56 subglottic subglottic JJ cord-335975-m6lkrehi 5142 57 suction suction NN cord-335975-m6lkrehi 5142 58 ( ( -LRB- cord-335975-m6lkrehi 5142 59 SG1 SG1 NNP cord-335975-m6lkrehi 5142 60 ) ) -RRB- cord-335975-m6lkrehi 5143 1 then then RB cord-335975-m6lkrehi 5143 2 O o UH cord-335975-m6lkrehi 5143 3 then then RB cord-335975-m6lkrehi 5143 4 SG2 SG2 NNP cord-335975-m6lkrehi 5143 5 then then RB cord-335975-m6lkrehi 5143 6 T T NNP cord-335975-m6lkrehi 5143 7 ) ) -RRB- cord-335975-m6lkrehi 5143 8 . . . cord-335975-m6lkrehi 5144 1 The the DT cord-335975-m6lkrehi 5144 2 amylase amylase NN cord-335975-m6lkrehi 5144 3 enzymatic enzymatic JJ cord-335975-m6lkrehi 5144 4 activity activity NN cord-335975-m6lkrehi 5144 5 has have VBZ cord-335975-m6lkrehi 5144 6 been be VBN cord-335975-m6lkrehi 5144 7 measured measure VBN cord-335975-m6lkrehi 5144 8 in in IN cord-335975-m6lkrehi 5144 9 O o NN cord-335975-m6lkrehi 5144 10 , , , cord-335975-m6lkrehi 5144 11 T T NNP cord-335975-m6lkrehi 5144 12 , , , cord-335975-m6lkrehi 5144 13 SG1 SG1 NNP cord-335975-m6lkrehi 5144 14 and and CC cord-335975-m6lkrehi 5144 15 SG2 SG2 NNP cord-335975-m6lkrehi 5144 16 suctions suction VBZ cord-335975-m6lkrehi 5144 17 as as IN cord-335975-m6lkrehi 5144 18 a a DT cord-335975-m6lkrehi 5144 19 surrogate surrogate NN cord-335975-m6lkrehi 5144 20 for for IN cord-335975-m6lkrehi 5144 21 the the DT cord-335975-m6lkrehi 5144 22 oropharyngeal oropharyngeal JJ cord-335975-m6lkrehi 5144 23 content content NN cord-335975-m6lkrehi 5144 24 . . . cord-335975-m6lkrehi 5145 1 If if IN cord-335975-m6lkrehi 5145 2 present present JJ cord-335975-m6lkrehi 5145 3 in in IN cord-335975-m6lkrehi 5145 4 T T NNP cord-335975-m6lkrehi 5145 5 suctions suction NNS cord-335975-m6lkrehi 5145 6 , , , cord-335975-m6lkrehi 5145 7 it -PRON- PRP cord-335975-m6lkrehi 5145 8 defines define VBZ cord-335975-m6lkrehi 5145 9 microaspiration microaspiration NN cord-335975-m6lkrehi 5145 10 . . . cord-335975-m6lkrehi 5146 1 Since since IN cord-335975-m6lkrehi 5146 2 the the DT cord-335975-m6lkrehi 5146 3 amylase amylase NN cord-335975-m6lkrehi 5146 4 O o NN cord-335975-m6lkrehi 5146 5 content content NN cord-335975-m6lkrehi 5146 6 is be VBZ cord-335975-m6lkrehi 5146 7 not not RB cord-335975-m6lkrehi 5146 8 similar similar JJ cord-335975-m6lkrehi 5146 9 from from IN cord-335975-m6lkrehi 5146 10 a a DT cord-335975-m6lkrehi 5146 11 patient patient NN cord-335975-m6lkrehi 5146 12 to to IN cord-335975-m6lkrehi 5146 13 another another DT cord-335975-m6lkrehi 5146 14 , , , cord-335975-m6lkrehi 5146 15 the the DT cord-335975-m6lkrehi 5146 16 primary primary JJ cord-335975-m6lkrehi 5146 17 outcome outcome NN cord-335975-m6lkrehi 5146 18 was be VBD cord-335975-m6lkrehi 5146 19 the the DT cord-335975-m6lkrehi 5146 20 median median JJ cord-335975-m6lkrehi 5146 21 amylaseT amylaset NN cord-335975-m6lkrehi 5146 22 O o NN cord-335975-m6lkrehi 5146 23 ratio ratio NN cord-335975-m6lkrehi 5146 24 after after IN cord-335975-m6lkrehi 5146 25 routine routine NN cord-335975-m6lkrehi 5146 26 versus versus IN cord-335975-m6lkrehi 5146 27 optimized optimized JJ cord-335975-m6lkrehi 5146 28 oral oral JJ cord-335975-m6lkrehi 5146 29 care care NN cord-335975-m6lkrehi 5146 30 . . . cord-335975-m6lkrehi 5147 1 Results result NNS cord-335975-m6lkrehi 5147 2 : : : cord-335975-m6lkrehi 5148 1 After after IN cord-335975-m6lkrehi 5148 2 informed informed JJ cord-335975-m6lkrehi 5148 3 consent consent NN cord-335975-m6lkrehi 5148 4 , , , cord-335975-m6lkrehi 5148 5 24 24 CD cord-335975-m6lkrehi 5148 6 patients patient NNS cord-335975-m6lkrehi 5148 7 were be VBD cord-335975-m6lkrehi 5148 8 included include VBN cord-335975-m6lkrehi 5148 9 . . . cord-335975-m6lkrehi 5149 1 21 21 CD cord-335975-m6lkrehi 5149 2 were be VBD cord-335975-m6lkrehi 5149 3 analyzed analyze VBN cord-335975-m6lkrehi 5149 4 due due JJ cord-335975-m6lkrehi 5149 5 to to IN cord-335975-m6lkrehi 5149 6 incomplete incomplete JJ cord-335975-m6lkrehi 5149 7 follow follow NN cord-335975-m6lkrehi 5149 8 - - HYPH cord-335975-m6lkrehi 5149 9 up up NN cord-335975-m6lkrehi 5149 10 in in IN cord-335975-m6lkrehi 5149 11 3 3 CD cord-335975-m6lkrehi 5149 12 patients patient NNS cord-335975-m6lkrehi 5149 13 . . . cord-335975-m6lkrehi 5150 1 Patients patient NNS cord-335975-m6lkrehi 5150 2 ( ( -LRB- cord-335975-m6lkrehi 5150 3 SAPSII SAPSII NNP cord-335975-m6lkrehi 5150 4 51 51 CD cord-335975-m6lkrehi 5150 5 ± ± CD cord-335975-m6lkrehi 5150 6 16 16 CD cord-335975-m6lkrehi 5150 7 ) ) -RRB- cord-335975-m6lkrehi 5150 8 were be VBD cord-335975-m6lkrehi 5150 9 ventilated ventilate VBN cord-335975-m6lkrehi 5150 10 since since IN cord-335975-m6lkrehi 5150 11 4.5 4.5 CD cord-335975-m6lkrehi 5150 12 ± ± CD cord-335975-m6lkrehi 5150 13 4.3 4.3 CD cord-335975-m6lkrehi 5150 14 days day NNS cord-335975-m6lkrehi 5150 15 for for IN cord-335975-m6lkrehi 5150 16 a a DT cord-335975-m6lkrehi 5150 17 majority majority NN cord-335975-m6lkrehi 5150 18 of of IN cord-335975-m6lkrehi 5150 19 respiratory respiratory JJ cord-335975-m6lkrehi 5150 20 indications indication NNS cord-335975-m6lkrehi 5150 21 . . . cord-335975-m6lkrehi 5151 1 At at IN cord-335975-m6lkrehi 5151 2 day day NN cord-335975-m6lkrehi 5151 3 1 1 CD cord-335975-m6lkrehi 5151 4 , , , cord-335975-m6lkrehi 5151 5 10 10 CD cord-335975-m6lkrehi 5151 6 and and CC cord-335975-m6lkrehi 5151 7 11 11 CD cord-335975-m6lkrehi 5151 8 patients patient NNS cord-335975-m6lkrehi 5151 9 received receive VBD cord-335975-m6lkrehi 5151 10 routine routine JJ cord-335975-m6lkrehi 5151 11 oral oral JJ cord-335975-m6lkrehi 5151 12 or or CC cord-335975-m6lkrehi 5151 13 optimized optimize VBN cord-335975-m6lkrehi 5151 14 oral oral JJ cord-335975-m6lkrehi 5151 15 car car NN cord-335975-m6lkrehi 5151 16 respectively respectively RB cord-335975-m6lkrehi 5151 17 without without IN cord-335975-m6lkrehi 5151 18 significant significant JJ cord-335975-m6lkrehi 5151 19 baseline baseline JJ cord-335975-m6lkrehi 5151 20 difference difference NN cord-335975-m6lkrehi 5151 21 . . . cord-335975-m6lkrehi 5152 1 A a DT cord-335975-m6lkrehi 5152 2 trend trend NN cord-335975-m6lkrehi 5152 3 in in IN cord-335975-m6lkrehi 5152 4 the the DT cord-335975-m6lkrehi 5152 5 reduction reduction NN cord-335975-m6lkrehi 5152 6 ( ( -LRB- cord-335975-m6lkrehi 5152 7 − − CD cord-335975-m6lkrehi 5152 8 35 35 CD cord-335975-m6lkrehi 5152 9 % % NN cord-335975-m6lkrehi 5152 10 ) ) -RRB- cord-335975-m6lkrehi 5152 11 of of IN cord-335975-m6lkrehi 5152 12 Amylase amylase NN cord-335975-m6lkrehi 5152 13 T T NNP cord-335975-m6lkrehi 5152 14 O o NN cord-335975-m6lkrehi 5152 15 median median NN cord-335975-m6lkrehi 5152 16 ratio ratio NN cord-335975-m6lkrehi 5152 17 was be VBD cord-335975-m6lkrehi 5152 18 observed observe VBN cord-335975-m6lkrehi 5152 19 after after IN cord-335975-m6lkrehi 5152 20 optimized optimize VBN cord-335975-m6lkrehi 5152 21 versus versus IN cord-335975-m6lkrehi 5152 22 routine routine JJ cord-335975-m6lkrehi 5152 23 oral oral JJ cord-335975-m6lkrehi 5152 24 care care NN cord-335975-m6lkrehi 5152 25 ( ( -LRB- cord-335975-m6lkrehi 5152 26 2.3 2.3 CD cord-335975-m6lkrehi 5152 27 % % NN cord-335975-m6lkrehi 5152 28 [ [ -LRB- cord-335975-m6lkrehi 5152 29 0.6 0.6 CD cord-335975-m6lkrehi 5152 30 - - SYM cord-335975-m6lkrehi 5152 31 6 6 CD cord-335975-m6lkrehi 5152 32 vs. vs. CC cord-335975-m6lkrehi 5152 33 1.5 1.5 CD cord-335975-m6lkrehi 5152 34 % % NN cord-335975-m6lkrehi 5152 35 [ [ -LRB- cord-335975-m6lkrehi 5152 36 0.7 0.7 CD cord-335975-m6lkrehi 5152 37 - - SYM cord-335975-m6lkrehi 5152 38 16 16 CD cord-335975-m6lkrehi 5152 39 ] ] -RRB- cord-335975-m6lkrehi 5152 40 , , , cord-335975-m6lkrehi 5152 41 p p NN cord-335975-m6lkrehi 5152 42 = = SYM cord-335975-m6lkrehi 5152 43 0.16 0.16 CD cord-335975-m6lkrehi 5152 44 . . . cord-335975-m6lkrehi 5153 1 Conclusion conclusion NN cord-335975-m6lkrehi 5153 2 : : : cord-335975-m6lkrehi 5154 1 Despite despite IN cord-335975-m6lkrehi 5154 2 protection protection NN cord-335975-m6lkrehi 5154 3 of of IN cord-335975-m6lkrehi 5154 4 trachea trachea NN cord-335975-m6lkrehi 5154 5 by by IN cord-335975-m6lkrehi 5154 6 the the DT cord-335975-m6lkrehi 5154 7 cuff cuff NN cord-335975-m6lkrehi 5154 8 of of IN cord-335975-m6lkrehi 5154 9 the the DT cord-335975-m6lkrehi 5154 10 endotracheal endotracheal NN cord-335975-m6lkrehi 5154 11 tube tube NN cord-335975-m6lkrehi 5154 12 , , , cord-335975-m6lkrehi 5154 13 amylase amylase NN cord-335975-m6lkrehi 5154 14 has have VBZ cord-335975-m6lkrehi 5154 15 been be VBN cord-335975-m6lkrehi 5154 16 found find VBN cord-335975-m6lkrehi 5154 17 in in IN cord-335975-m6lkrehi 5154 18 tracheal tracheal JJ cord-335975-m6lkrehi 5154 19 suctions suction NNS cord-335975-m6lkrehi 5154 20 ( ( -LRB- cord-335975-m6lkrehi 5154 21 which which WDT cord-335975-m6lkrehi 5154 22 represents represent VBZ cord-335975-m6lkrehi 5154 23 the the DT cord-335975-m6lkrehi 5154 24 last last JJ cord-335975-m6lkrehi 5154 25 step step NN cord-335975-m6lkrehi 5154 26 of of IN cord-335975-m6lkrehi 5154 27 oral oral JJ cord-335975-m6lkrehi 5154 28 care care NN cord-335975-m6lkrehi 5154 29 ) ) -RRB- cord-335975-m6lkrehi 5154 30 . . . cord-335975-m6lkrehi 5155 1 In in IN cord-335975-m6lkrehi 5155 2 this this DT cord-335975-m6lkrehi 5155 3 pilot pilot NN cord-335975-m6lkrehi 5155 4 study study NN cord-335975-m6lkrehi 5155 5 with with IN cord-335975-m6lkrehi 5155 6 a a DT cord-335975-m6lkrehi 5155 7 limited limited JJ cord-335975-m6lkrehi 5155 8 sample sample NN cord-335975-m6lkrehi 5155 9 of of IN cord-335975-m6lkrehi 5155 10 patients patient NNS cord-335975-m6lkrehi 5155 11 , , , cord-335975-m6lkrehi 5155 12 a a DT cord-335975-m6lkrehi 5155 13 trend trend NN cord-335975-m6lkrehi 5155 14 in in IN cord-335975-m6lkrehi 5155 15 the the DT cord-335975-m6lkrehi 5155 16 reduction reduction NN cord-335975-m6lkrehi 5155 17 of of IN cord-335975-m6lkrehi 5155 18 microaspirations microaspiration NNS cord-335975-m6lkrehi 5155 19 was be VBD cord-335975-m6lkrehi 5155 20 observed observe VBN cord-335975-m6lkrehi 5155 21 when when WRB cord-335975-m6lkrehi 5155 22 subglottic subglottic JJ cord-335975-m6lkrehi 5155 23 suctions suction NNS cord-335975-m6lkrehi 5155 24 were be VBD cord-335975-m6lkrehi 5155 25 interleaved interleave VBN cord-335975-m6lkrehi 5155 26 between between IN cord-335975-m6lkrehi 5155 27 oral oral JJ cord-335975-m6lkrehi 5155 28 and and CC cord-335975-m6lkrehi 5155 29 tracheal tracheal JJ cord-335975-m6lkrehi 5155 30 suctions suction NNS cord-335975-m6lkrehi 5155 31 . . . cord-335975-m6lkrehi 5156 1 An an DT cord-335975-m6lkrehi 5156 2 increased increase VBN cord-335975-m6lkrehi 5156 3 sample sample NN cord-335975-m6lkrehi 5156 4 power power NN cord-335975-m6lkrehi 5156 5 could could MD cord-335975-m6lkrehi 5156 6 show show VB cord-335975-m6lkrehi 5156 7 more more RBR cord-335975-m6lkrehi 5156 8 significant significant JJ cord-335975-m6lkrehi 5156 9 results result NNS cord-335975-m6lkrehi 5156 10 , , , cord-335975-m6lkrehi 5156 11 but but CC cord-335975-m6lkrehi 5156 12 we -PRON- PRP cord-335975-m6lkrehi 5156 13 can can MD cord-335975-m6lkrehi 5156 14 not not RB cord-335975-m6lkrehi 5156 15 eliminate eliminate VB cord-335975-m6lkrehi 5156 16 that that IN cord-335975-m6lkrehi 5156 17 this this DT cord-335975-m6lkrehi 5156 18 weak weak JJ cord-335975-m6lkrehi 5156 19 effect effect NN cord-335975-m6lkrehi 5156 20 could could MD cord-335975-m6lkrehi 5156 21 also also RB cord-335975-m6lkrehi 5156 22 be be VB cord-335975-m6lkrehi 5156 23 due due JJ cord-335975-m6lkrehi 5156 24 to to IN cord-335975-m6lkrehi 5156 25 the the DT cord-335975-m6lkrehi 5156 26 inability inability NN cord-335975-m6lkrehi 5156 27 of of IN cord-335975-m6lkrehi 5156 28 subglottic subglottic JJ cord-335975-m6lkrehi 5156 29 suctions suction NNS cord-335975-m6lkrehi 5156 30 to to TO cord-335975-m6lkrehi 5156 31 prevent prevent VB cord-335975-m6lkrehi 5156 32 microaspiration microaspiration NN cord-335975-m6lkrehi 5156 33 of of IN cord-335975-m6lkrehi 5156 34 the the DT cord-335975-m6lkrehi 5156 35 oral oral JJ cord-335975-m6lkrehi 5156 36 content content NN cord-335975-m6lkrehi 5156 37 . . . cord-335975-m6lkrehi 5157 1 The the DT cord-335975-m6lkrehi 5157 2 study study NN cord-335975-m6lkrehi 5157 3 has have VBZ cord-335975-m6lkrehi 5157 4 been be VBN cord-335975-m6lkrehi 5157 5 founded found VBN cord-335975-m6lkrehi 5157 6 by by IN cord-335975-m6lkrehi 5157 7 Teleflex Teleflex NNP cord-335975-m6lkrehi 5157 8 . . . cord-335975-m6lkrehi 5158 1 Introduction introduction NN cord-335975-m6lkrehi 5158 2 : : : cord-335975-m6lkrehi 5159 1 Although although IN cord-335975-m6lkrehi 5159 2 necessary necessary JJ cord-335975-m6lkrehi 5159 3 , , , cord-335975-m6lkrehi 5159 4 mechanical mechanical JJ cord-335975-m6lkrehi 5159 5 ventilation ventilation NN cord-335975-m6lkrehi 5159 6 can can MD cord-335975-m6lkrehi 5159 7 lead lead VB cord-335975-m6lkrehi 5159 8 to to IN cord-335975-m6lkrehi 5159 9 ventilator ventilator NN cord-335975-m6lkrehi 5159 10 - - HYPH cord-335975-m6lkrehi 5159 11 induced induce VBN cord-335975-m6lkrehi 5159 12 lung lung NN cord-335975-m6lkrehi 5159 13 injury injury NN cord-335975-m6lkrehi 5159 14 ( ( -LRB- cord-335975-m6lkrehi 5159 15 VILI VILI NNP cord-335975-m6lkrehi 5159 16 ) ) -RRB- cord-335975-m6lkrehi 5159 17 even even RB cord-335975-m6lkrehi 5159 18 when when WRB cord-335975-m6lkrehi 5159 19 using use VBG cord-335975-m6lkrehi 5159 20 protective protective JJ cord-335975-m6lkrehi 5159 21 ventilation ventilation NN cord-335975-m6lkrehi 5159 22 strategies strategy NNS cord-335975-m6lkrehi 5159 23 that that WDT cord-335975-m6lkrehi 5159 24 combine combine VBP cord-335975-m6lkrehi 5159 25 low low JJ cord-335975-m6lkrehi 5159 26 tidal tidal JJ cord-335975-m6lkrehi 5159 27 volume volume NN cord-335975-m6lkrehi 5159 28 ( ( -LRB- cord-335975-m6lkrehi 5159 29 Vt)(6 Vt)(6 NNP cord-335975-m6lkrehi 5159 30 ml ml NNP cord-335975-m6lkrehi 5159 31 kg kg NNP cord-335975-m6lkrehi 5159 32 predicted predict VBD cord-335975-m6lkrehi 5159 33 body body NN cord-335975-m6lkrehi 5159 34 weight weight NN cord-335975-m6lkrehi 5159 35 ) ) -RRB- cord-335975-m6lkrehi 5159 36 and and CC cord-335975-m6lkrehi 5159 37 plateau plateau NN cord-335975-m6lkrehi 5159 38 pressure pressure NN cord-335975-m6lkrehi 5159 39 ( ( -LRB- cord-335975-m6lkrehi 5159 40 Pplat Pplat NNP cord-335975-m6lkrehi 5159 41 ) ) -RRB- cord-335975-m6lkrehi 5160 1 < < XX cord-335975-m6lkrehi 5160 2 = = SYM cord-335975-m6lkrehi 5160 3 30cmH20 30cmh20 CD cord-335975-m6lkrehi 5160 4 . . . cord-335975-m6lkrehi 5161 1 Lower lower VB cord-335975-m6lkrehi 5161 2 positive positive JJ cord-335975-m6lkrehi 5161 3 pressures pressure NNS cord-335975-m6lkrehi 5161 4 and and CC cord-335975-m6lkrehi 5161 5 tidal tidal JJ cord-335975-m6lkrehi 5161 6 volumes volume NNS cord-335975-m6lkrehi 5161 7 could could MD cord-335975-m6lkrehi 5161 8 enhance enhance VB cord-335975-m6lkrehi 5161 9 lung lung NN cord-335975-m6lkrehi 5161 10 protection protection NN cord-335975-m6lkrehi 5161 11 + + CC cord-335975-m6lkrehi 5161 12 the the DT cord-335975-m6lkrehi 5161 13 HLA HLA NNP cord-335975-m6lkrehi 5161 14 - - HYPH cord-335975-m6lkrehi 5161 15 DR DR NNP cord-335975-m6lkrehi 5161 16 and and CC cord-335975-m6lkrehi 5161 17 PD PD NNP cord-335975-m6lkrehi 5161 18 - - HYPH cord-335975-m6lkrehi 5161 19 L1 L1 NNP cord-335975-m6lkrehi 5161 20 expressions expression NNS cord-335975-m6lkrehi 5161 21 were be VBD cord-335975-m6lkrehi 5161 22 higher high JJR cord-335975-m6lkrehi 5161 23 on on IN cord-335975-m6lkrehi 5161 24 alveolar alveolar NN cord-335975-m6lkrehi 5161 25 than than IN cord-335975-m6lkrehi 5161 26 on on IN cord-335975-m6lkrehi 5161 27 blood blood NN cord-335975-m6lkrehi 5161 28 monocytes monocyte NNS cord-335975-m6lkrehi 5161 29 in in IN cord-335975-m6lkrehi 5161 30 both both DT cord-335975-m6lkrehi 5161 31 ARDS ARDS NNP cord-335975-m6lkrehi 5161 32 patients patient NNS cord-335975-m6lkrehi 5161 33 and and CC cord-335975-m6lkrehi 5161 34 controls control NNS cord-335975-m6lkrehi 5161 35 ( ( -LRB- cord-335975-m6lkrehi 5161 36 Figure figure NN cord-335975-m6lkrehi 5161 37 ) ) -RRB- cord-335975-m6lkrehi 5161 38 . . . cord-335975-m6lkrehi 5162 1 Yet yet RB cord-335975-m6lkrehi 5162 2 , , , cord-335975-m6lkrehi 5162 3 HLA HLA NNP cord-335975-m6lkrehi 5162 4 - - HYPH cord-335975-m6lkrehi 5162 5 DR DR NNP cord-335975-m6lkrehi 5162 6 expression expression NN cord-335975-m6lkrehi 5162 7 on on IN cord-335975-m6lkrehi 5162 8 alveolar alveolar NN cord-335975-m6lkrehi 5162 9 monocytes monocyte NNS cord-335975-m6lkrehi 5162 10 was be VBD cord-335975-m6lkrehi 5162 11 higher high JJR cord-335975-m6lkrehi 5162 12 in in IN cord-335975-m6lkrehi 5162 13 controls control NNS cord-335975-m6lkrehi 5162 14 compared compare VBN cord-335975-m6lkrehi 5162 15 to to IN cord-335975-m6lkrehi 5162 16 ARDS ARDS NNP cord-335975-m6lkrehi 5162 17 patients patient NNS cord-335975-m6lkrehi 5162 18 ( ( -LRB- cord-335975-m6lkrehi 5162 19 p p NN cord-335975-m6lkrehi 5162 20 = = SYM cord-335975-m6lkrehi 5162 21 0.004 0.004 CD cord-335975-m6lkrehi 5162 22 ) ) -RRB- cord-335975-m6lkrehi 5162 23 . . . cord-335975-m6lkrehi 5163 1 Circulating circulate VBG cord-335975-m6lkrehi 5163 2 monocytes monocyte NNS cord-335975-m6lkrehi 5163 3 had have VBD cord-335975-m6lkrehi 5163 4 a a DT cord-335975-m6lkrehi 5163 5 higher high JJR cord-335975-m6lkrehi 5163 6 phagocytic phagocytic JJ cord-335975-m6lkrehi 5163 7 activity activity NN cord-335975-m6lkrehi 5163 8 than than IN cord-335975-m6lkrehi 5163 9 alveolar alveolar NN cord-335975-m6lkrehi 5163 10 monocytes monocyte NNS cord-335975-m6lkrehi 5163 11 ( ( -LRB- cord-335975-m6lkrehi 5163 12 p p NN cord-335975-m6lkrehi 5163 13 < < XX cord-335975-m6lkrehi 5163 14 0.001 0.001 CD cord-335975-m6lkrehi 5163 15 ) ) -RRB- cord-335975-m6lkrehi 5163 16 , , , cord-335975-m6lkrehi 5163 17 but but CC cord-335975-m6lkrehi 5163 18 no no DT cord-335975-m6lkrehi 5163 19 significant significant JJ cord-335975-m6lkrehi 5163 20 difference difference NN cord-335975-m6lkrehi 5163 21 was be VBD cord-335975-m6lkrehi 5163 22 observed observe VBN cord-335975-m6lkrehi 5163 23 between between IN cord-335975-m6lkrehi 5163 24 ARDS ARDS NNP cord-335975-m6lkrehi 5163 25 patients patient NNS cord-335975-m6lkrehi 5163 26 and and CC cord-335975-m6lkrehi 5163 27 controls control NNS cord-335975-m6lkrehi 5163 28 . . . cord-335975-m6lkrehi 5164 1 An an DT cord-335975-m6lkrehi 5164 2 LPS LPS NNP cord-335975-m6lkrehi 5164 3 challenge challenge NN cord-335975-m6lkrehi 5164 4 increased increase VBD cord-335975-m6lkrehi 5164 5 the the DT cord-335975-m6lkrehi 5164 6 phagocytic phagocytic JJ cord-335975-m6lkrehi 5164 7 activity activity NN cord-335975-m6lkrehi 5164 8 of of IN cord-335975-m6lkrehi 5164 9 monocytes monocyte NNS cord-335975-m6lkrehi 5164 10 in in IN cord-335975-m6lkrehi 5164 11 controls control NNS cord-335975-m6lkrehi 5164 12 ( ( -LRB- cord-335975-m6lkrehi 5164 13 p p NN cord-335975-m6lkrehi 5164 14 = = SYM cord-335975-m6lkrehi 5164 15 0.03 0.03 CD cord-335975-m6lkrehi 5164 16 ) ) -RRB- cord-335975-m6lkrehi 5164 17 but but CC cord-335975-m6lkrehi 5164 18 not not RB cord-335975-m6lkrehi 5164 19 in in IN cord-335975-m6lkrehi 5164 20 ARDS ARDS NNP cord-335975-m6lkrehi 5164 21 monocytes monocyte NNS cord-335975-m6lkrehi 5164 22 ( ( -LRB- cord-335975-m6lkrehi 5164 23 p p NN cord-335975-m6lkrehi 5164 24 = = SYM cord-335975-m6lkrehi 5164 25 0.88 0.88 CD cord-335975-m6lkrehi 5164 26 ) ) -RRB- cord-335975-m6lkrehi 5164 27 . . . cord-335975-m6lkrehi 5165 1 TNF TNF NNP cord-335975-m6lkrehi 5165 2 - - HYPH cord-335975-m6lkrehi 5165 3 α α NNP cord-335975-m6lkrehi 5165 4 intracellular intracellular JJ cord-335975-m6lkrehi 5165 5 synthesis synthesis NN cord-335975-m6lkrehi 5165 6 was be VBD cord-335975-m6lkrehi 5165 7 increased increase VBN cord-335975-m6lkrehi 5165 8 after after IN cord-335975-m6lkrehi 5165 9 LPS LPS NNP cord-335975-m6lkrehi 5165 10 exposure exposure NN cord-335975-m6lkrehi 5165 11 in in IN cord-335975-m6lkrehi 5165 12 circulating circulate VBG cord-335975-m6lkrehi 5165 13 and and CC cord-335975-m6lkrehi 5165 14 alveolar alveolar NN cord-335975-m6lkrehi 5165 15 monocytes monocyte NNS cord-335975-m6lkrehi 5165 16 of of IN cord-335975-m6lkrehi 5165 17 controls control NNS cord-335975-m6lkrehi 5165 18 ( ( -LRB- cord-335975-m6lkrehi 5165 19 p p NN cord-335975-m6lkrehi 5165 20 < < XX cord-335975-m6lkrehi 5165 21 0.05 0.05 CD cord-335975-m6lkrehi 5165 22 ) ) -RRB- cord-335975-m6lkrehi 5165 23 but but CC cord-335975-m6lkrehi 5165 24 only only RB cord-335975-m6lkrehi 5165 25 tended tend VBD cord-335975-m6lkrehi 5165 26 to to TO cord-335975-m6lkrehi 5165 27 do do VB cord-335975-m6lkrehi 5165 28 so so RB cord-335975-m6lkrehi 5165 29 in in IN cord-335975-m6lkrehi 5165 30 ARDS ARDS NNP cord-335975-m6lkrehi 5165 31 ( ( -LRB- cord-335975-m6lkrehi 5165 32 p p NN cord-335975-m6lkrehi 5165 33 = = SYM cord-335975-m6lkrehi 5165 34 0.08 0.08 CD cord-335975-m6lkrehi 5165 35 ) ) -RRB- cord-335975-m6lkrehi 5165 36 . . . cord-335975-m6lkrehi 5166 1 Conclusion conclusion NN cord-335975-m6lkrehi 5166 2 : : : cord-335975-m6lkrehi 5167 1 Differences difference NNS cord-335975-m6lkrehi 5167 2 in in IN cord-335975-m6lkrehi 5167 3 the the DT cord-335975-m6lkrehi 5167 4 phenotype phenotype NN cord-335975-m6lkrehi 5167 5 of of IN cord-335975-m6lkrehi 5167 6 alveolar alveolar NN cord-335975-m6lkrehi 5167 7 and and CC cord-335975-m6lkrehi 5167 8 circulating circulate VBG cord-335975-m6lkrehi 5167 9 monocytes monocyte NNS cord-335975-m6lkrehi 5167 10 were be VBD cord-335975-m6lkrehi 5167 11 observed observe VBN cord-335975-m6lkrehi 5167 12 in in IN cord-335975-m6lkrehi 5167 13 ARDS ARDS NNP cord-335975-m6lkrehi 5167 14 but but CC cord-335975-m6lkrehi 5167 15 also also RB cord-335975-m6lkrehi 5167 16 in in IN cord-335975-m6lkrehi 5167 17 controls control NNS cord-335975-m6lkrehi 5167 18 , , , cord-335975-m6lkrehi 5167 19 suggesting suggest VBG cord-335975-m6lkrehi 5167 20 a a DT cord-335975-m6lkrehi 5167 21 physiological physiological JJ cord-335975-m6lkrehi 5167 22 lung lung NN cord-335975-m6lkrehi 5167 23 blood blood NN cord-335975-m6lkrehi 5167 24 gradient gradient NN cord-335975-m6lkrehi 5167 25 in in IN cord-335975-m6lkrehi 5167 26 the the DT cord-335975-m6lkrehi 5167 27 expression expression NN cord-335975-m6lkrehi 5167 28 of of IN cord-335975-m6lkrehi 5167 29 these these DT cord-335975-m6lkrehi 5167 30 Results result NNS cord-335975-m6lkrehi 5167 31 : : : cord-335975-m6lkrehi 5167 32 Until until IN cord-335975-m6lkrehi 5167 33 31 31 CD cord-335975-m6lkrehi 5167 34 03 03 CD cord-335975-m6lkrehi 5167 35 2016 2016 CD cord-335975-m6lkrehi 5167 36 , , , cord-335975-m6lkrehi 5167 37 ten ten CD cord-335975-m6lkrehi 5167 38 patients patient NNS cord-335975-m6lkrehi 5167 39 were be VBD cord-335975-m6lkrehi 5167 40 included include VBN cord-335975-m6lkrehi 5167 41 and and CC cord-335975-m6lkrehi 5167 42 analyzed analyze VBN cord-335975-m6lkrehi 5167 43 for for IN cord-335975-m6lkrehi 5167 44 the the DT cord-335975-m6lkrehi 5167 45 study study NN cord-335975-m6lkrehi 5167 46 . . . cord-335975-m6lkrehi 5168 1 There there EX cord-335975-m6lkrehi 5168 2 was be VBD cord-335975-m6lkrehi 5168 3 a a DT cord-335975-m6lkrehi 5168 4 significant significant JJ cord-335975-m6lkrehi 5168 5 difference difference NN cord-335975-m6lkrehi 5168 6 between between IN cord-335975-m6lkrehi 5168 7 the the DT cord-335975-m6lkrehi 5168 8 volumes volume NNS cord-335975-m6lkrehi 5168 9 recruited recruit VBN cord-335975-m6lkrehi 5168 10 at at IN cord-335975-m6lkrehi 5168 11 the the DT cord-335975-m6lkrehi 5168 12 three three CD cord-335975-m6lkrehi 5168 13 PEEP peep NN cord-335975-m6lkrehi 5168 14 levels level NNS cord-335975-m6lkrehi 5168 15 ( ( -LRB- cord-335975-m6lkrehi 5168 16 p p NN cord-335975-m6lkrehi 5168 17 = = SYM cord-335975-m6lkrehi 5168 18 0.002 0.002 CD cord-335975-m6lkrehi 5168 19 ) ) -RRB- cord-335975-m6lkrehi 5168 20 . . . cord-335975-m6lkrehi 5169 1 The the DT cord-335975-m6lkrehi 5169 2 recruitment recruitment NN cord-335975-m6lkrehi 5169 3 evaluated evaluate VBN cord-335975-m6lkrehi 5169 4 was be VBD cord-335975-m6lkrehi 5169 5 not not RB cord-335975-m6lkrehi 5169 6 correlated correlate VBN cord-335975-m6lkrehi 5169 7 with with IN cord-335975-m6lkrehi 5169 8 PaO2 PaO2 NNS cord-335975-m6lkrehi 5169 9 . . . cord-335975-m6lkrehi 5170 1 There there EX cord-335975-m6lkrehi 5170 2 is be VBZ cord-335975-m6lkrehi 5170 3 a a DT cord-335975-m6lkrehi 5170 4 significant significant JJ cord-335975-m6lkrehi 5170 5 decrease decrease NN cord-335975-m6lkrehi 5170 6 in in IN cord-335975-m6lkrehi 5170 7 cardiac cardiac JJ cord-335975-m6lkrehi 5170 8 index index NN cord-335975-m6lkrehi 5170 9 and and CC cord-335975-m6lkrehi 5170 10 PAM PAM NNP cord-335975-m6lkrehi 5170 11 caused cause VBN cord-335975-m6lkrehi 5170 12 by by IN cord-335975-m6lkrehi 5170 13 the the DT cord-335975-m6lkrehi 5170 14 increase increase NN cord-335975-m6lkrehi 5170 15 in in IN cord-335975-m6lkrehi 5170 16 PEEP PEEP NNP cord-335975-m6lkrehi 5170 17 . . . cord-335975-m6lkrehi 5171 1 Conclusion conclusion NN cord-335975-m6lkrehi 5171 2 : : : cord-335975-m6lkrehi 5172 1 Preliminary preliminary JJ cord-335975-m6lkrehi 5172 2 results result NNS cord-335975-m6lkrehi 5172 3 from from IN cord-335975-m6lkrehi 5172 4 our -PRON- PRP$ cord-335975-m6lkrehi 5172 5 study study NN cord-335975-m6lkrehi 5172 6 suggest suggest VBP cord-335975-m6lkrehi 5172 7 that that IN cord-335975-m6lkrehi 5172 8 the the DT cord-335975-m6lkrehi 5172 9 estimated estimate VBN cord-335975-m6lkrehi 5172 10 recruited recruit VBN cord-335975-m6lkrehi 5172 11 lung lung NN cord-335975-m6lkrehi 5172 12 volume volume NN cord-335975-m6lkrehi 5172 13 estimated estimate VBN cord-335975-m6lkrehi 5172 14 by by IN cord-335975-m6lkrehi 5172 15 CRF CRF NNP cord-335975-m6lkrehi 5173 1 INview INview NNP cord-335975-m6lkrehi 5173 2 ® ® NN cord-335975-m6lkrehi 5173 3 technology technology NN cord-335975-m6lkrehi 5173 4 appears appear VBZ cord-335975-m6lkrehi 5173 5 to to TO cord-335975-m6lkrehi 5173 6 be be VB cord-335975-m6lkrehi 5173 7 poorly poorly RB cord-335975-m6lkrehi 5173 8 correlated correlate VBN cord-335975-m6lkrehi 5173 9 with with IN cord-335975-m6lkrehi 5173 10 measured measure VBN cord-335975-m6lkrehi 5173 11 PaO2 PaO2 NNS cord-335975-m6lkrehi 5173 12 . . . cord-335975-m6lkrehi 5174 1 The the DT cord-335975-m6lkrehi 5174 2 hemodynamic hemodynamic JJ cord-335975-m6lkrehi 5174 3 repercussions repercussion NNS cord-335975-m6lkrehi 5174 4 observed observe VBN cord-335975-m6lkrehi 5174 5 should should MD cord-335975-m6lkrehi 5174 6 also also RB cord-335975-m6lkrehi 5174 7 be be VB cord-335975-m6lkrehi 5174 8 considered consider VBN cord-335975-m6lkrehi 5174 9 in in IN cord-335975-m6lkrehi 5174 10 order order NN cord-335975-m6lkrehi 5174 11 to to TO cord-335975-m6lkrehi 5174 12 propose propose VB cord-335975-m6lkrehi 5174 13 an an DT cord-335975-m6lkrehi 5174 14 optimal optimal JJ cord-335975-m6lkrehi 5174 15 strategy strategy NN cord-335975-m6lkrehi 5174 16 for for IN cord-335975-m6lkrehi 5174 17 the the DT cord-335975-m6lkrehi 5174 18 optimal optimal JJ cord-335975-m6lkrehi 5174 19 adjustment adjustment NN cord-335975-m6lkrehi 5174 20 of of IN cord-335975-m6lkrehi 5174 21 PEEP peep NN cord-335975-m6lkrehi 5174 22 . . . cord-335975-m6lkrehi 5175 1 were be VBD cord-335975-m6lkrehi 5175 2 compliant compliant JJ cord-335975-m6lkrehi 5175 3 with with IN cord-335975-m6lkrehi 5175 4 the the DT cord-335975-m6lkrehi 5175 5 re re NN cord-335975-m6lkrehi 5175 6 - - NN cord-335975-m6lkrehi 5175 7 evaluation evaluation NN cord-335975-m6lkrehi 5175 8 . . . cord-335975-m6lkrehi 5176 1 191 191 CD cord-335975-m6lkrehi 5176 2 ( ( -LRB- cord-335975-m6lkrehi 5176 3 85 85 CD cord-335975-m6lkrehi 5176 4 % % NN cord-335975-m6lkrehi 5176 5 ) ) -RRB- cord-335975-m6lkrehi 5176 6 patients patient NNS cord-335975-m6lkrehi 5176 7 received receive VBD cord-335975-m6lkrehi 5176 8 carbapenems carbapenem NNS cord-335975-m6lkrehi 5176 9 according accord VBG cord-335975-m6lkrehi 5176 10 to to IN cord-335975-m6lkrehi 5176 11 the the DT cord-335975-m6lkrehi 5176 12 recommendations recommendation NNS cord-335975-m6lkrehi 5176 13 . . . cord-335975-m6lkrehi 5177 1 A a DT cord-335975-m6lkrehi 5177 2 compliant compliant JJ cord-335975-m6lkrehi 5177 3 prescription prescription NN cord-335975-m6lkrehi 5177 4 had have VBD cord-335975-m6lkrehi 5177 5 no no DT cord-335975-m6lkrehi 5177 6 impact impact NN cord-335975-m6lkrehi 5177 7 on on IN cord-335975-m6lkrehi 5177 8 hospital hospital NN cord-335975-m6lkrehi 5177 9 or or CC cord-335975-m6lkrehi 5177 10 ICU ICU NNP cord-335975-m6lkrehi 5177 11 length length NN cord-335975-m6lkrehi 5177 12 of of IN cord-335975-m6lkrehi 5177 13 stay stay NN cord-335975-m6lkrehi 5177 14 and and CC cord-335975-m6lkrehi 5177 15 no no DT cord-335975-m6lkrehi 5177 16 impact impact NN cord-335975-m6lkrehi 5177 17 on on IN cord-335975-m6lkrehi 5177 18 duration duration NN cord-335975-m6lkrehi 5177 19 of of IN cord-335975-m6lkrehi 5177 20 mechanical mechanical JJ cord-335975-m6lkrehi 5177 21 ventilation ventilation NN cord-335975-m6lkrehi 5177 22 but but CC cord-335975-m6lkrehi 5177 23 seemed seem VBD cord-335975-m6lkrehi 5177 24 associated associate VBN cord-335975-m6lkrehi 5177 25 with with IN cord-335975-m6lkrehi 5177 26 increase increase NN cord-335975-m6lkrehi 5177 27 mortality mortality NN cord-335975-m6lkrehi 5177 28 ( ( -LRB- cord-335975-m6lkrehi 5177 29 p p NN cord-335975-m6lkrehi 5177 30 = = SYM cord-335975-m6lkrehi 5177 31 0.04 0.04 CD cord-335975-m6lkrehi 5177 32 ) ) -RRB- cord-335975-m6lkrehi 5177 33 . . . cord-335975-m6lkrehi 5178 1 Discussion discussion NN cord-335975-m6lkrehi 5178 2 : : : cord-335975-m6lkrehi 5179 1 The the DT cord-335975-m6lkrehi 5179 2 high high JJ cord-335975-m6lkrehi 5179 3 rate rate NN cord-335975-m6lkrehi 5179 4 of of IN cord-335975-m6lkrehi 5179 5 compliant compliant JJ cord-335975-m6lkrehi 5179 6 prescriptions prescription NNS cord-335975-m6lkrehi 5179 7 can can MD cord-335975-m6lkrehi 5179 8 be be VB cord-335975-m6lkrehi 5179 9 explained explain VBN cord-335975-m6lkrehi 5179 10 by by IN cord-335975-m6lkrehi 5179 11 the the DT cord-335975-m6lkrehi 5179 12 broad broad JJ cord-335975-m6lkrehi 5179 13 indications indication NNS cord-335975-m6lkrehi 5179 14 of of IN cord-335975-m6lkrehi 5179 15 carbapenems carbapenem NNS cord-335975-m6lkrehi 5179 16 in in IN cord-335975-m6lkrehi 5179 17 the the DT cord-335975-m6lkrehi 5179 18 ICU ICU NNP cord-335975-m6lkrehi 5179 19 , , , cord-335975-m6lkrehi 5179 20 especially especially RB cord-335975-m6lkrehi 5179 21 in in IN cord-335975-m6lkrehi 5179 22 patients patient NNS cord-335975-m6lkrehi 5179 23 with with IN cord-335975-m6lkrehi 5179 24 septic septic JJ cord-335975-m6lkrehi 5179 25 shock shock NN cord-335975-m6lkrehi 5179 26 . . . cord-335975-m6lkrehi 5180 1 The the DT cord-335975-m6lkrehi 5180 2 increase increase NN cord-335975-m6lkrehi 5180 3 mortality mortality NN cord-335975-m6lkrehi 5180 4 of of IN cord-335975-m6lkrehi 5180 5 patients patient NNS cord-335975-m6lkrehi 5180 6 with with IN cord-335975-m6lkrehi 5180 7 a a DT cord-335975-m6lkrehi 5180 8 compliant compliant JJ cord-335975-m6lkrehi 5180 9 prescription prescription NN cord-335975-m6lkrehi 5180 10 is be VBZ cord-335975-m6lkrehi 5180 11 probably probably RB cord-335975-m6lkrehi 5180 12 due due JJ cord-335975-m6lkrehi 5180 13 to to IN cord-335975-m6lkrehi 5180 14 the the DT cord-335975-m6lkrehi 5180 15 severity severity NN cord-335975-m6lkrehi 5180 16 of of IN cord-335975-m6lkrehi 5180 17 the the DT cord-335975-m6lkrehi 5180 18 infections infection NNS cord-335975-m6lkrehi 5180 19 . . . cord-335975-m6lkrehi 5181 1 In in IN cord-335975-m6lkrehi 5181 2 order order NN cord-335975-m6lkrehi 5181 3 to to TO cord-335975-m6lkrehi 5181 4 achieve achieve VB cord-335975-m6lkrehi 5181 5 100 100 CD cord-335975-m6lkrehi 5181 6 % % NN cord-335975-m6lkrehi 5181 7 compliance compliance NN cord-335975-m6lkrehi 5181 8 , , , cord-335975-m6lkrehi 5181 9 we -PRON- PRP cord-335975-m6lkrehi 5181 10 could could MD cord-335975-m6lkrehi 5181 11 suggested suggest VBD cord-335975-m6lkrehi 5181 12 regularly regularly RB cord-335975-m6lkrehi 5181 13 updating update VBG cord-335975-m6lkrehi 5181 14 the the DT cord-335975-m6lkrehi 5181 15 knowledge knowledge NN cord-335975-m6lkrehi 5181 16 of of IN cord-335975-m6lkrehi 5181 17 carbapenems carbapenem NNS cord-335975-m6lkrehi 5181 18 prescriptions prescription NNS cord-335975-m6lkrehi 5181 19 , , , cord-335975-m6lkrehi 5181 20 collaborating collaborate VBG cord-335975-m6lkrehi 5181 21 with with IN cord-335975-m6lkrehi 5181 22 bacteriology bacteriology NN cord-335975-m6lkrehi 5181 23 and and CC cord-335975-m6lkrehi 5181 24 infectiology infectiology NN cord-335975-m6lkrehi 5181 25 teams team NNS cord-335975-m6lkrehi 5181 26 , , , cord-335975-m6lkrehi 5181 27 and and CC cord-335975-m6lkrehi 5181 28 establishing establish VBG cord-335975-m6lkrehi 5181 29 a a DT cord-335975-m6lkrehi 5181 30 computerized computerized JJ cord-335975-m6lkrehi 5181 31 or or CC cord-335975-m6lkrehi 5181 32 paper paper NN cord-335975-m6lkrehi 5181 33 prescription prescription NN cord-335975-m6lkrehi 5181 34 with with IN cord-335975-m6lkrehi 5181 35 feedback feedback NN cord-335975-m6lkrehi 5181 36 control control NN cord-335975-m6lkrehi 5181 37 . . . cord-335975-m6lkrehi 5182 1 Conclusion conclusion NN cord-335975-m6lkrehi 5182 2 : : : cord-335975-m6lkrehi 5182 3 The the DT cord-335975-m6lkrehi 5182 4 prescription prescription NN cord-335975-m6lkrehi 5182 5 of of IN cord-335975-m6lkrehi 5182 6 carbapenems carbapenem NNS cord-335975-m6lkrehi 5182 7 appears appear VBZ cord-335975-m6lkrehi 5182 8 most most RBS cord-335975-m6lkrehi 5182 9 often often RB cord-335975-m6lkrehi 5182 10 in in IN cord-335975-m6lkrehi 5182 11 accordance accordance NN cord-335975-m6lkrehi 5182 12 with with IN cord-335975-m6lkrehi 5182 13 the the DT cord-335975-m6lkrehi 5182 14 recommendations recommendation NNS cord-335975-m6lkrehi 5182 15 in in IN cord-335975-m6lkrehi 5182 16 this this DT cord-335975-m6lkrehi 5182 17 ICU ICU NNP cord-335975-m6lkrehi 5182 18 . . . cord-335975-m6lkrehi 5183 1 However however RB cord-335975-m6lkrehi 5183 2 , , , cord-335975-m6lkrehi 5183 3 there there EX cord-335975-m6lkrehi 5183 4 is be VBZ cord-335975-m6lkrehi 5183 5 a a DT cord-335975-m6lkrehi 5183 6 need need NN cord-335975-m6lkrehi 5183 7 for for IN cord-335975-m6lkrehi 5183 8 improvement improvement NN cord-335975-m6lkrehi 5183 9 . . . cord-335975-m6lkrehi 5184 1 Introduction introduction NN cord-335975-m6lkrehi 5184 2 : : : cord-335975-m6lkrehi 5185 1 Bacterial bacterial JJ cord-335975-m6lkrehi 5185 2 infections infection NNS cord-335975-m6lkrehi 5185 3 are be VBP cord-335975-m6lkrehi 5185 4 frequent frequent JJ cord-335975-m6lkrehi 5185 5 triggers trigger NNS cord-335975-m6lkrehi 5185 6 for for IN cord-335975-m6lkrehi 5185 7 diabetic diabetic JJ cord-335975-m6lkrehi 5185 8 ketoacidosis ketoacidosis NN cord-335975-m6lkrehi 5185 9 and and CC cord-335975-m6lkrehi 5185 10 a a DT cord-335975-m6lkrehi 5185 11 significant significant JJ cord-335975-m6lkrehi 5185 12 increase increase NN cord-335975-m6lkrehi 5185 13 in in IN cord-335975-m6lkrehi 5185 14 morbimortality morbimortality NN cord-335975-m6lkrehi 5185 15 is be VBZ cord-335975-m6lkrehi 5185 16 observed observe VBN cord-335975-m6lkrehi 5185 17 in in IN cord-335975-m6lkrehi 5185 18 case case NN cord-335975-m6lkrehi 5185 19 of of IN cord-335975-m6lkrehi 5185 20 delayed delay VBN cord-335975-m6lkrehi 5185 21 antibiotic antibiotic JJ cord-335975-m6lkrehi 5185 22 treatment treatment NN cord-335975-m6lkrehi 5185 23 . . . cord-335975-m6lkrehi 5186 1 However however RB cord-335975-m6lkrehi 5186 2 the the DT cord-335975-m6lkrehi 5186 3 unnecessary unnecessary JJ cord-335975-m6lkrehi 5186 4 administration administration NN cord-335975-m6lkrehi 5186 5 of of IN cord-335975-m6lkrehi 5186 6 antimicrobial antimicrobial JJ cord-335975-m6lkrehi 5186 7 therapy therapy NN cord-335975-m6lkrehi 5186 8 can can MD cord-335975-m6lkrehi 5186 9 also also RB cord-335975-m6lkrehi 5186 10 lead lead VB cord-335975-m6lkrehi 5186 11 to to IN cord-335975-m6lkrehi 5186 12 bacterial bacterial JJ cord-335975-m6lkrehi 5186 13 resistance resistance NN cord-335975-m6lkrehi 5186 14 . . . cord-335975-m6lkrehi 5187 1 Early early JJ cord-335975-m6lkrehi 5187 2 sepsis sepsis NN cord-335975-m6lkrehi 5187 3 markers marker NNS cord-335975-m6lkrehi 5187 4 are be VBP cord-335975-m6lkrehi 5187 5 thus thus RB cord-335975-m6lkrehi 5187 6 particularly particularly RB cord-335975-m6lkrehi 5187 7 useful useful JJ cord-335975-m6lkrehi 5187 8 for for IN cord-335975-m6lkrehi 5187 9 patients patient NNS cord-335975-m6lkrehi 5187 10 admitted admit VBN cord-335975-m6lkrehi 5187 11 in in IN cord-335975-m6lkrehi 5187 12 ICU ICU NNP cord-335975-m6lkrehi 5187 13 for for IN cord-335975-m6lkrehi 5187 14 diabetic diabetic JJ cord-335975-m6lkrehi 5187 15 ketoacidosis ketoacidosis NN cord-335975-m6lkrehi 5187 16 . . . cord-335975-m6lkrehi 5188 1 Patients patient NNS cord-335975-m6lkrehi 5188 2 and and CC cord-335975-m6lkrehi 5188 3 methods method NNS cord-335975-m6lkrehi 5188 4 : : : cord-335975-m6lkrehi 5188 5 We -PRON- PRP cord-335975-m6lkrehi 5188 6 retrospectively retrospectively RB cord-335975-m6lkrehi 5188 7 studied study VBD cord-335975-m6lkrehi 5188 8 cases case NNS cord-335975-m6lkrehi 5188 9 of of IN cord-335975-m6lkrehi 5188 10 patients patient NNS cord-335975-m6lkrehi 5188 11 admitted admit VBN cord-335975-m6lkrehi 5188 12 in in IN cord-335975-m6lkrehi 5188 13 ICU ICU NNP cord-335975-m6lkrehi 5188 14 at at IN cord-335975-m6lkrehi 5188 15 Avicenne Avicenne NNP cord-335975-m6lkrehi 5188 16 French French NNP cord-335975-m6lkrehi 5188 17 Universitary Universitary NNP cord-335975-m6lkrehi 5188 18 hospital hospital NN cord-335975-m6lkrehi 5188 19 for for IN cord-335975-m6lkrehi 5188 20 ketoacidosis ketoacidosis NN cord-335975-m6lkrehi 5188 21 defined define VBN cord-335975-m6lkrehi 5188 22 by by IN cord-335975-m6lkrehi 5188 23 pH pH NNP cord-335975-m6lkrehi 5188 24 < < XX cord-335975-m6lkrehi 5188 25 7.3 7.3 CD cord-335975-m6lkrehi 5188 26 and and CC cord-335975-m6lkrehi 5188 27 glycemia glycemia NN cord-335975-m6lkrehi 5188 28 > > XX cord-335975-m6lkrehi 5189 1 13.75 13.75 CD cord-335975-m6lkrehi 5189 2 mmol mmol JJ cord-335975-m6lkrehi 5189 3 L. L. NNP cord-335975-m6lkrehi 5189 4 Clinical Clinical NNP cord-335975-m6lkrehi 5189 5 and and CC cord-335975-m6lkrehi 5189 6 biological biological JJ cord-335975-m6lkrehi 5189 7 data datum NNS cord-335975-m6lkrehi 5189 8 were be VBD cord-335975-m6lkrehi 5189 9 analyzed analyze VBN cord-335975-m6lkrehi 5189 10 at at IN cord-335975-m6lkrehi 5189 11 admission admission NN cord-335975-m6lkrehi 5189 12 ( ( -LRB- cord-335975-m6lkrehi 5189 13 D0 D0 NNP cord-335975-m6lkrehi 5189 14 ) ) -RRB- cord-335975-m6lkrehi 5189 15 and and CC cord-335975-m6lkrehi 5189 16 on on IN cord-335975-m6lkrehi 5189 17 day day NN cord-335975-m6lkrehi 5189 18 2 2 CD cord-335975-m6lkrehi 5189 19 ( ( -LRB- cord-335975-m6lkrehi 5189 20 D2 d2 NN cord-335975-m6lkrehi 5189 21 ) ) -RRB- cord-335975-m6lkrehi 5189 22 . . . cord-335975-m6lkrehi 5190 1 Results result NNS cord-335975-m6lkrehi 5190 2 : : : cord-335975-m6lkrehi 5191 1 Between between IN cord-335975-m6lkrehi 5191 2 2010 2010 CD cord-335975-m6lkrehi 5191 3 and and CC cord-335975-m6lkrehi 5191 4 2016 2016 CD cord-335975-m6lkrehi 5191 5 , , , cord-335975-m6lkrehi 5191 6 among among IN cord-335975-m6lkrehi 5191 7 93 93 CD cord-335975-m6lkrehi 5191 8 patients patient NNS cord-335975-m6lkrehi 5191 9 admitted admit VBN cord-335975-m6lkrehi 5191 10 for for IN cord-335975-m6lkrehi 5191 11 diabetic diabetic JJ cord-335975-m6lkrehi 5191 12 ketoacidosis ketoacidosis NN cord-335975-m6lkrehi 5191 13 , , , cord-335975-m6lkrehi 5191 14 69 69 CD cord-335975-m6lkrehi 5191 15 were be VBD cord-335975-m6lkrehi 5191 16 included include VBN cord-335975-m6lkrehi 5191 17 . . . cord-335975-m6lkrehi 5192 1 Twelve twelve CD cord-335975-m6lkrehi 5192 2 out out IN cord-335975-m6lkrehi 5192 3 of of IN cord-335975-m6lkrehi 5192 4 69 69 CD cord-335975-m6lkrehi 5192 5 were be VBD cord-335975-m6lkrehi 5192 6 infected infect VBN cord-335975-m6lkrehi 5192 7 ( ( -LRB- cord-335975-m6lkrehi 5192 8 5 5 CD cord-335975-m6lkrehi 5192 9 urosepsis urosepsis NN cord-335975-m6lkrehi 5192 10 , , , cord-335975-m6lkrehi 5192 11 5 5 CD cord-335975-m6lkrehi 5192 12 pneumonia pneumonia NN cord-335975-m6lkrehi 5192 13 , , , cord-335975-m6lkrehi 5192 14 2 2 CD cord-335975-m6lkrehi 5192 15 others other NNS cord-335975-m6lkrehi 5192 16 ) ) -RRB- cord-335975-m6lkrehi 5192 17 . . . cord-335975-m6lkrehi 5193 1 Demographic demographic JJ cord-335975-m6lkrehi 5193 2 data datum NNS cord-335975-m6lkrehi 5193 3 and and CC cord-335975-m6lkrehi 5193 4 comorbidities comorbiditie NNS cord-335975-m6lkrehi 5193 5 did do VBD cord-335975-m6lkrehi 5193 6 not not RB cord-335975-m6lkrehi 5193 7 significantly significantly RB cord-335975-m6lkrehi 5193 8 differ differ VB cord-335975-m6lkrehi 5193 9 between between IN cord-335975-m6lkrehi 5193 10 the the DT cord-335975-m6lkrehi 5193 11 infected infected JJ cord-335975-m6lkrehi 5193 12 and and CC cord-335975-m6lkrehi 5193 13 non non JJ cord-335975-m6lkrehi 5193 14 infected infected JJ cord-335975-m6lkrehi 5193 15 group group NN cord-335975-m6lkrehi 5193 16 ( ( -LRB- cord-335975-m6lkrehi 5193 17 IG IG NNP cord-335975-m6lkrehi 5193 18 and and CC cord-335975-m6lkrehi 5193 19 NIG NIG NNP cord-335975-m6lkrehi 5193 20 ) ) -RRB- cord-335975-m6lkrehi 5193 21 . . . cord-335975-m6lkrehi 5194 1 Antibiotics antibiotic NNS cord-335975-m6lkrehi 5194 2 were be VBD cord-335975-m6lkrehi 5194 3 administered administer VBN cord-335975-m6lkrehi 5194 4 to to IN cord-335975-m6lkrehi 5194 5 33 33 CD cord-335975-m6lkrehi 5194 6 patients-12 patients-12 CD cord-335975-m6lkrehi 5194 7 12 12 CD cord-335975-m6lkrehi 5194 8 ( ( -LRB- cord-335975-m6lkrehi 5194 9 100 100 CD cord-335975-m6lkrehi 5194 10 % % NN cord-335975-m6lkrehi 5194 11 ) ) -RRB- cord-335975-m6lkrehi 5194 12 in in IN cord-335975-m6lkrehi 5194 13 the the DT cord-335975-m6lkrehi 5194 14 infected infected JJ cord-335975-m6lkrehi 5194 15 group group NN cord-335975-m6lkrehi 5194 16 versus versus IN cord-335975-m6lkrehi 5194 17 21 21 CD cord-335975-m6lkrehi 5194 18 57 57 CD cord-335975-m6lkrehi 5194 19 ( ( -LRB- cord-335975-m6lkrehi 5194 20 36.8 36.8 CD cord-335975-m6lkrehi 5194 21 % % NN cord-335975-m6lkrehi 5194 22 ) ) -RRB- cord-335975-m6lkrehi 5194 23 in in IN cord-335975-m6lkrehi 5194 24 the the DT cord-335975-m6lkrehi 5194 25 non non JJ cord-335975-m6lkrehi 5194 26 infected infected JJ cord-335975-m6lkrehi 5194 27 group group NN cord-335975-m6lkrehi 5194 28 . . . cord-335975-m6lkrehi 5195 1 On on IN cord-335975-m6lkrehi 5195 2 D0 d0 NN cord-335975-m6lkrehi 5195 3 , , , cord-335975-m6lkrehi 5195 4 there there EX cord-335975-m6lkrehi 5195 5 was be VBD cord-335975-m6lkrehi 5195 6 no no DT cord-335975-m6lkrehi 5195 7 difference difference NN cord-335975-m6lkrehi 5195 8 for for IN cord-335975-m6lkrehi 5195 9 - - HYPH cord-335975-m6lkrehi 5195 10 pH ph NN cord-335975-m6lkrehi 5195 11 , , , cord-335975-m6lkrehi 5195 12 temperature temperature NN cord-335975-m6lkrehi 5195 13 , , , cord-335975-m6lkrehi 5195 14 leukocytes leukocyte NNS cord-335975-m6lkrehi 5195 15 , , , cord-335975-m6lkrehi 5195 16 neutrophils neutrophil NNS cord-335975-m6lkrehi 5195 17 - - HYPH cord-335975-m6lkrehi 5195 18 to to IN cord-335975-m6lkrehi 5195 19 - - HYPH cord-335975-m6lkrehi 5195 20 lymphocytes lymphocyte NNS cord-335975-m6lkrehi 5195 21 count count VBP cord-335975-m6lkrehi 5195 22 ratio ratio NN cord-335975-m6lkrehi 5195 23 and and CC cord-335975-m6lkrehi 5195 24 PCT PCT NNP cord-335975-m6lkrehi 5196 1 ( ( -LRB- cord-335975-m6lkrehi 5196 2 Table table NN cord-335975-m6lkrehi 5196 3 1 1 CD cord-335975-m6lkrehi 5196 4 ) ) -RRB- cord-335975-m6lkrehi 5196 5 . . . cord-335975-m6lkrehi 5197 1 On on IN cord-335975-m6lkrehi 5197 2 D2 d2 NN cord-335975-m6lkrehi 5197 3 , , , cord-335975-m6lkrehi 5197 4 temperature temperature NN cord-335975-m6lkrehi 5197 5 , , , cord-335975-m6lkrehi 5197 6 leukocytes leukocyte NNS cord-335975-m6lkrehi 5197 7 , , , cord-335975-m6lkrehi 5197 8 neutrophils neutrophil NNS cord-335975-m6lkrehi 5197 9 - - HYPH cord-335975-m6lkrehi 5197 10 to to IN cord-335975-m6lkrehi 5197 11 - - HYPH cord-335975-m6lkrehi 5197 12 lymphocytes lymphocyte NNS cord-335975-m6lkrehi 5197 13 count count VBP cord-335975-m6lkrehi 5197 14 ratio ratio NN cord-335975-m6lkrehi 5197 15 and and CC cord-335975-m6lkrehi 5197 16 PCT PCT NNP cord-335975-m6lkrehi 5197 17 were be VBD cord-335975-m6lkrehi 5197 18 significantly significantly RB cord-335975-m6lkrehi 5197 19 higher high JJR cord-335975-m6lkrehi 5197 20 in in IN cord-335975-m6lkrehi 5197 21 the the DT cord-335975-m6lkrehi 5197 22 IG ig NN cord-335975-m6lkrehi 5197 23 . . . cord-335975-m6lkrehi 5198 1 In in IN cord-335975-m6lkrehi 5198 2 the the DT cord-335975-m6lkrehi 5198 3 IG ig NN cord-335975-m6lkrehi 5198 4 , , , cord-335975-m6lkrehi 5198 5 the the DT cord-335975-m6lkrehi 5198 6 biological biological JJ cord-335975-m6lkrehi 5198 7 markers marker NNS cord-335975-m6lkrehi 5198 8 did do VBD cord-335975-m6lkrehi 5198 9 not not RB cord-335975-m6lkrehi 5198 10 vary vary VB cord-335975-m6lkrehi 5198 11 between between IN cord-335975-m6lkrehi 5198 12 D0 d0 NN cord-335975-m6lkrehi 5198 13 and and CC cord-335975-m6lkrehi 5198 14 D2 d2 NN cord-335975-m6lkrehi 5198 15 , , , cord-335975-m6lkrehi 5198 16 whereas whereas IN cord-335975-m6lkrehi 5198 17 in in IN cord-335975-m6lkrehi 5198 18 the the DT cord-335975-m6lkrehi 5198 19 NIG NIG NNP cord-335975-m6lkrehi 5198 20 , , , cord-335975-m6lkrehi 5198 21 leukocytes leukocyte NNS cord-335975-m6lkrehi 5198 22 ( ( -LRB- cord-335975-m6lkrehi 5198 23 p p NN cord-335975-m6lkrehi 5198 24 < < XX cord-335975-m6lkrehi 5198 25 0.0001 0.0001 CD cord-335975-m6lkrehi 5198 26 ) ) -RRB- cord-335975-m6lkrehi 5198 27 , , , cord-335975-m6lkrehi 5198 28 PNN PNN NNP cord-335975-m6lkrehi 5198 29 ( ( -LRB- cord-335975-m6lkrehi 5198 30 p p NN cord-335975-m6lkrehi 5198 31 < < XX cord-335975-m6lkrehi 5198 32 0.0001 0.0001 CD cord-335975-m6lkrehi 5198 33 ) ) -RRB- cord-335975-m6lkrehi 5198 34 and and CC cord-335975-m6lkrehi 5198 35 neutrophils neutrophil NNS cord-335975-m6lkrehi 5198 36 - - HYPH cord-335975-m6lkrehi 5198 37 to to IN cord-335975-m6lkrehi 5198 38 - - HYPH cord-335975-m6lkrehi 5198 39 lymphocytes lymphocyte NNS cord-335975-m6lkrehi 5198 40 count count NN cord-335975-m6lkrehi 5198 41 ratio ratio NN cord-335975-m6lkrehi 5198 42 ( ( -LRB- cord-335975-m6lkrehi 5198 43 p p NN cord-335975-m6lkrehi 5198 44 < < XX cord-335975-m6lkrehi 5198 45 0.0001 0.0001 CD cord-335975-m6lkrehi 5198 46 ) ) -RRB- cord-335975-m6lkrehi 5198 47 significantly significantly RB cord-335975-m6lkrehi 5198 48 decreased decrease VBD cord-335975-m6lkrehi 5198 49 . . . cord-335975-m6lkrehi 5199 1 Surprisingly surprisingly RB cord-335975-m6lkrehi 5199 2 average average JJ cord-335975-m6lkrehi 5199 3 PCT PCT NNP cord-335975-m6lkrehi 5199 4 levels level NNS cord-335975-m6lkrehi 5199 5 seem seem VBP cord-335975-m6lkrehi 5199 6 to to TO cord-335975-m6lkrehi 5199 7 be be VB cord-335975-m6lkrehi 5199 8 particularly particularly RB cord-335975-m6lkrehi 5199 9 high high JJ cord-335975-m6lkrehi 5199 10 in in IN cord-335975-m6lkrehi 5199 11 the the DT cord-335975-m6lkrehi 5199 12 NIG NIG NNP cord-335975-m6lkrehi 5199 13 on on IN cord-335975-m6lkrehi 5199 14 DO DO NNP cord-335975-m6lkrehi 5199 15 as as RB cord-335975-m6lkrehi 5199 16 well well RB cord-335975-m6lkrehi 5199 17 as as IN cord-335975-m6lkrehi 5199 18 on on IN cord-335975-m6lkrehi 5199 19 D2 D2 NNP cord-335975-m6lkrehi 5199 20 . . . cord-335975-m6lkrehi 5200 1 Conclusion conclusion NN cord-335975-m6lkrehi 5200 2 : : : cord-335975-m6lkrehi 5201 1 At at IN cord-335975-m6lkrehi 5201 2 admission admission NN cord-335975-m6lkrehi 5201 3 , , , cord-335975-m6lkrehi 5201 4 PCT PCT NNP cord-335975-m6lkrehi 5201 5 as as RB cord-335975-m6lkrehi 5201 6 well well RB cord-335975-m6lkrehi 5201 7 as as IN cord-335975-m6lkrehi 5201 8 other other JJ cord-335975-m6lkrehi 5201 9 usual usual JJ cord-335975-m6lkrehi 5201 10 markers marker NNS cord-335975-m6lkrehi 5201 11 do do VBP cord-335975-m6lkrehi 5201 12 not not RB cord-335975-m6lkrehi 5201 13 appear appear VB cord-335975-m6lkrehi 5201 14 to to TO cord-335975-m6lkrehi 5201 15 be be VB cord-335975-m6lkrehi 5201 16 useful useful JJ cord-335975-m6lkrehi 5201 17 to to TO cord-335975-m6lkrehi 5201 18 differentiate differentiate VB cord-335975-m6lkrehi 5201 19 infected infect VBN cord-335975-m6lkrehi 5201 20 from from IN cord-335975-m6lkrehi 5201 21 non non JJ cord-335975-m6lkrehi 5201 22 infected infected JJ cord-335975-m6lkrehi 5201 23 patients patient NNS cord-335975-m6lkrehi 5201 24 admitted admit VBN cord-335975-m6lkrehi 5201 25 for for IN cord-335975-m6lkrehi 5201 26 ketoacidosis ketoacidosis NN cord-335975-m6lkrehi 5201 27 . . . cord-335975-m6lkrehi 5202 1 However however RB cord-335975-m6lkrehi 5202 2 , , , cord-335975-m6lkrehi 5202 3 on on IN cord-335975-m6lkrehi 5202 4 day day NN cord-335975-m6lkrehi 5202 5 2 2 CD cord-335975-m6lkrehi 5202 6 , , , cord-335975-m6lkrehi 5202 7 two two CD cord-335975-m6lkrehi 5202 8 different different JJ cord-335975-m6lkrehi 5202 9 patterns pattern NNS cord-335975-m6lkrehi 5202 10 can can MD cord-335975-m6lkrehi 5202 11 be be VB cord-335975-m6lkrehi 5202 12 drawn draw VBN cord-335975-m6lkrehi 5202 13 and and CC cord-335975-m6lkrehi 5202 14 help help VB cord-335975-m6lkrehi 5202 15 detecting detect VBG cord-335975-m6lkrehi 5202 16 non non JJ cord-335975-m6lkrehi 5202 17 - - JJ cord-335975-m6lkrehi 5202 18 infected infected JJ cord-335975-m6lkrehi 5202 19 patients patient NNS cord-335975-m6lkrehi 5202 20 and and CC cord-335975-m6lkrehi 5202 21 thus thus RB cord-335975-m6lkrehi 5202 22 reduce reduce VB cord-335975-m6lkrehi 5202 23 exposure exposure NN cord-335975-m6lkrehi 5202 24 to to IN cord-335975-m6lkrehi 5202 25 antibiotics antibiotic NNS cord-335975-m6lkrehi 5202 26 . . . cord-335975-m6lkrehi 5203 1 These these DT cord-335975-m6lkrehi 5203 2 results result NNS cord-335975-m6lkrehi 5203 3 should should MD cord-335975-m6lkrehi 5203 4 be be VB cord-335975-m6lkrehi 5203 5 confirmed confirm VBN cord-335975-m6lkrehi 5203 6 by by IN cord-335975-m6lkrehi 5203 7 a a DT cord-335975-m6lkrehi 5203 8 prospective prospective JJ cord-335975-m6lkrehi 5203 9 study study NN cord-335975-m6lkrehi 5203 10 , , , cord-335975-m6lkrehi 5203 11 including include VBG cord-335975-m6lkrehi 5203 12 a a DT cord-335975-m6lkrehi 5203 13 larger large JJR cord-335975-m6lkrehi 5203 14 number number NN cord-335975-m6lkrehi 5203 15 of of IN cord-335975-m6lkrehi 5203 16 patients patient NNS cord-335975-m6lkrehi 5203 17 . . . cord-335975-m6lkrehi 5204 1 Ventilator ventilator NN cord-335975-m6lkrehi 5204 2 - - HYPH cord-335975-m6lkrehi 5204 3 associated associate VBN cord-335975-m6lkrehi 5204 4 events event NNS cord-335975-m6lkrehi 5204 5 ( ( -LRB- cord-335975-m6lkrehi 5204 6 VAE VAE NNP cord-335975-m6lkrehi 5204 7 ) ) -RRB- cord-335975-m6lkrehi 5204 8 , , , cord-335975-m6lkrehi 5204 9 reflecting reflect VBG cord-335975-m6lkrehi 5204 10 worsening worsen VBG cord-335975-m6lkrehi 5204 11 oxygenation oxygenation NN cord-335975-m6lkrehi 5204 12 , , , cord-335975-m6lkrehi 5204 13 are be VBP cord-335975-m6lkrehi 5204 14 defined define VBN cord-335975-m6lkrehi 5204 15 as as IN cord-335975-m6lkrehi 5204 16 a a DT cord-335975-m6lkrehi 5204 17 persistent persistent JJ cord-335975-m6lkrehi 5204 18 and and CC cord-335975-m6lkrehi 5204 19 significant significant JJ cord-335975-m6lkrehi 5204 20 increase increase NN cord-335975-m6lkrehi 5204 21 in in IN cord-335975-m6lkrehi 5204 22 FiO fio NN cord-335975-m6lkrehi 5204 23 2 2 CD cord-335975-m6lkrehi 5204 24 or or CC cord-335975-m6lkrehi 5204 25 PEEP peep NN cord-335975-m6lkrehi 5204 26 level level NN cord-335975-m6lkrehi 5204 27 after after IN cord-335975-m6lkrehi 5204 28 a a DT cord-335975-m6lkrehi 5204 29 period period NN cord-335975-m6lkrehi 5204 30 of of IN cord-335975-m6lkrehi 5204 31 stability stability NN cord-335975-m6lkrehi 5204 32 on on IN cord-335975-m6lkrehi 5204 33 the the DT cord-335975-m6lkrehi 5204 34 ventilator ventilator NN cord-335975-m6lkrehi 5204 35 . . . cord-335975-m6lkrehi 5205 1 VAE VAE NNP cord-335975-m6lkrehi 5205 2 definition definition NN cord-335975-m6lkrehi 5205 3 includes include VBZ cord-335975-m6lkrehi 5205 4 ventilator ventilator NN cord-335975-m6lkrehi 5205 5 - - HYPH cord-335975-m6lkrehi 5205 6 associated associate VBN cord-335975-m6lkrehi 5205 7 conditions condition NNS cord-335975-m6lkrehi 5205 8 ( ( -LRB- cord-335975-m6lkrehi 5205 9 VAC VAC NNP cord-335975-m6lkrehi 5205 10 ) ) -RRB- cord-335975-m6lkrehi 5205 11 , , , cord-335975-m6lkrehi 5205 12 infection infection NN cord-335975-m6lkrehi 5205 13 - - HYPH cord-335975-m6lkrehi 5205 14 related relate VBN cord-335975-m6lkrehi 5205 15 ventilatorassociated ventilatorassociated JJ cord-335975-m6lkrehi 5205 16 complications complication NNS cord-335975-m6lkrehi 5205 17 ( ( -LRB- cord-335975-m6lkrehi 5205 18 IVAC IVAC NNP cord-335975-m6lkrehi 5205 19 ) ) -RRB- cord-335975-m6lkrehi 5205 20 and and CC cord-335975-m6lkrehi 5205 21 probable probable JJ cord-335975-m6lkrehi 5205 22 ventilator ventilator NN cord-335975-m6lkrehi 5205 23 - - HYPH cord-335975-m6lkrehi 5205 24 associated associate VBN cord-335975-m6lkrehi 5205 25 pneumonia pneumonia NN cord-335975-m6lkrehi 5205 26 ( ( -LRB- cord-335975-m6lkrehi 5205 27 PVAP PVAP NNP cord-335975-m6lkrehi 5205 28 ) ) -RRB- cord-335975-m6lkrehi 5205 29 . . . cord-335975-m6lkrehi 5206 1 The the DT cord-335975-m6lkrehi 5206 2 relevance relevance NN cord-335975-m6lkrehi 5206 3 of of IN cord-335975-m6lkrehi 5206 4 VAE VAE NNP cord-335975-m6lkrehi 5206 5 for for IN cord-335975-m6lkrehi 5206 6 ventilator ventilator NN cord-335975-m6lkrehi 5206 7 - - HYPH cord-335975-m6lkrehi 5206 8 associated associate VBN cord-335975-m6lkrehi 5206 9 pneumonia pneumonia NN cord-335975-m6lkrehi 5206 10 ( ( -LRB- cord-335975-m6lkrehi 5206 11 VAP VAP NNP cord-335975-m6lkrehi 5206 12 ) ) -RRB- cord-335975-m6lkrehi 5206 13 is be VBZ cord-335975-m6lkrehi 5206 14 low low JJ cord-335975-m6lkrehi 5206 15 . . . cord-335975-m6lkrehi 5207 1 However however RB cord-335975-m6lkrehi 5207 2 , , , cord-335975-m6lkrehi 5207 3 the the DT cord-335975-m6lkrehi 5207 4 correlation correlation NN cord-335975-m6lkrehi 5207 5 between between IN cord-335975-m6lkrehi 5207 6 the the DT cord-335975-m6lkrehi 5207 7 three three CD cord-335975-m6lkrehi 5207 8 VAC vac NN cord-335975-m6lkrehi 5207 9 , , , cord-335975-m6lkrehi 5207 10 IVAC IVAC NNP cord-335975-m6lkrehi 5207 11 , , , cord-335975-m6lkrehi 5207 12 and and CC cord-335975-m6lkrehi 5207 13 PVAP PVAP NNP cord-335975-m6lkrehi 5207 14 , , , cord-335975-m6lkrehi 5207 15 and and CC cord-335975-m6lkrehi 5207 16 the the DT cord-335975-m6lkrehi 5207 17 onset onset NN cord-335975-m6lkrehi 5207 18 of of IN cord-335975-m6lkrehi 5207 19 ventilator ventilator NN cord-335975-m6lkrehi 5207 20 - - HYPH cord-335975-m6lkrehi 5207 21 associated associate VBN cord-335975-m6lkrehi 5207 22 low low JJ cord-335975-m6lkrehi 5207 23 respiratory respiratory JJ cord-335975-m6lkrehi 5207 24 tract tract NN cord-335975-m6lkrehi 5207 25 infection infection NN cord-335975-m6lkrehi 5207 26 ( ( -LRB- cord-335975-m6lkrehi 5207 27 VALRTI VALRTI NNP cord-335975-m6lkrehi 5207 28 ) ) -RRB- cord-335975-m6lkrehi 5207 29 , , , cord-335975-m6lkrehi 5207 30 including include VBG cord-335975-m6lkrehi 5207 31 ventilator ventilator NN cord-335975-m6lkrehi 5207 32 - - HYPH cord-335975-m6lkrehi 5207 33 associated associate VBN cord-335975-m6lkrehi 5207 34 tracheobronchitis tracheobronchitis NNP cord-335975-m6lkrehi 5207 35 ( ( -LRB- cord-335975-m6lkrehi 5207 36 VAT VAT NNP cord-335975-m6lkrehi 5207 37 ) ) -RRB- cord-335975-m6lkrehi 5207 38 and and CC cord-335975-m6lkrehi 5207 39 pneumonia pneumonia NN cord-335975-m6lkrehi 5207 40 ( ( -LRB- cord-335975-m6lkrehi 5207 41 VAP VAP NNP cord-335975-m6lkrehi 5207 42 ) ) -RRB- cord-335975-m6lkrehi 5207 43 , , , cord-335975-m6lkrehi 5207 44 has have VBZ cord-335975-m6lkrehi 5207 45 never never RB cord-335975-m6lkrehi 5207 46 been be VBN cord-335975-m6lkrehi 5207 47 studied study VBN cord-335975-m6lkrehi 5207 48 yet yet RB cord-335975-m6lkrehi 5207 49 . . . cord-335975-m6lkrehi 5208 1 We -PRON- PRP cord-335975-m6lkrehi 5208 2 on on IN cord-335975-m6lkrehi 5208 3 clinical clinical JJ cord-335975-m6lkrehi 5208 4 examination examination NN cord-335975-m6lkrehi 5208 5 . . . cord-335975-m6lkrehi 5209 1 Gravity gravity NN cord-335975-m6lkrehi 5209 2 scores score NNS cord-335975-m6lkrehi 5209 3 - - : cord-335975-m6lkrehi 5209 4 APACHE APACHE NNP cord-335975-m6lkrehi 5209 5 II II NNP cord-335975-m6lkrehi 5209 6 and and CC cord-335975-m6lkrehi 5209 7 SAPS SAPS NNP cord-335975-m6lkrehi 5209 8 II II NNP cord-335975-m6lkrehi 5209 9 . . . cord-335975-m6lkrehi 5210 1 For for IN cord-335975-m6lkrehi 5210 2 lumbar lumbar JJ cord-335975-m6lkrehi 5210 3 puncture puncture NN cord-335975-m6lkrehi 5210 4 data datum NNS cord-335975-m6lkrehi 5210 5 , , , cord-335975-m6lkrehi 5210 6 there there EX cord-335975-m6lkrehi 5210 7 is be VBZ cord-335975-m6lkrehi 5210 8 the the DT cord-335975-m6lkrehi 5210 9 proteinuria proteinuria NN cord-335975-m6lkrehi 5210 10 , , , cord-335975-m6lkrehi 5210 11 glycorrhaphy glycorrhaphy NN cord-335975-m6lkrehi 5210 12 Resuscitation resuscitation NN cord-335975-m6lkrehi 5210 13 measures measure NNS cord-335975-m6lkrehi 5210 14 - - HYPH cord-335975-m6lkrehi 5210 15 drug drug NN cord-335975-m6lkrehi 5210 16 intake intake NN cord-335975-m6lkrehi 5210 17 and and CC cord-335975-m6lkrehi 5210 18 intubationIn intubationin VB cord-335975-m6lkrehi 5210 19 multivariate multivariate JJ cord-335975-m6lkrehi 5210 20 analysis analysis NN cord-335975-m6lkrehi 5210 21 , , , cord-335975-m6lkrehi 5210 22 the the DT cord-335975-m6lkrehi 5210 23 factors factor NNS cord-335975-m6lkrehi 5210 24 of of IN cord-335975-m6lkrehi 5210 25 pejorative pejorative JJ cord-335975-m6lkrehi 5210 26 evolution evolution NN cord-335975-m6lkrehi 5210 27 - - : cord-335975-m6lkrehi 5210 28 The the DT cord-335975-m6lkrehi 5210 29 male male JJ cord-335975-m6lkrehi 5210 30 sex sex NN cord-335975-m6lkrehi 5210 31 Presence presence NN cord-335975-m6lkrehi 5210 32 of of IN cord-335975-m6lkrehi 5210 33 meningeal meningeal JJ cord-335975-m6lkrehi 5210 34 syndrome syndrome NN cord-335975-m6lkrehi 5210 35 . . . cord-335975-m6lkrehi 5211 1 High high JJ cord-335975-m6lkrehi 5211 2 proteinorachia proteinorachia NNS cord-335975-m6lkrehi 5211 3 . . . cord-335975-m6lkrehi 5212 1 Taking take VBG cord-335975-m6lkrehi 5212 2 vasoactive vasoactive JJ cord-335975-m6lkrehi 5212 3 drugs drug NNS cord-335975-m6lkrehi 5212 4 . . . cord-335975-m6lkrehi 5213 1 The the DT cord-335975-m6lkrehi 5213 2 SAPS SAPS NNP cord-335975-m6lkrehi 5213 3 II II NNP cord-335975-m6lkrehi 5213 4 score score NN cord-335975-m6lkrehi 5213 5 . . . cord-335975-m6lkrehi 5214 1 Conclusion conclusion NN cord-335975-m6lkrehi 5214 2 : : : cord-335975-m6lkrehi 5215 1 According accord VBG cord-335975-m6lkrehi 5215 2 to to IN cord-335975-m6lkrehi 5215 3 this this DT cord-335975-m6lkrehi 5215 4 work work NN cord-335975-m6lkrehi 5215 5 , , , cord-335975-m6lkrehi 5215 6 many many JJ cord-335975-m6lkrehi 5215 7 factors factor NNS cord-335975-m6lkrehi 5215 8 influence influence VBP cord-335975-m6lkrehi 5215 9 the the DT cord-335975-m6lkrehi 5215 10 prognosis prognosis NN cord-335975-m6lkrehi 5215 11 of of IN cord-335975-m6lkrehi 5215 12 acute acute JJ cord-335975-m6lkrehi 5215 13 meningitis meningitis NN cord-335975-m6lkrehi 5215 14 in in IN cord-335975-m6lkrehi 5215 15 our -PRON- PRP$ cord-335975-m6lkrehi 5215 16 population population NN cord-335975-m6lkrehi 5215 17 such such JJ cord-335975-m6lkrehi 5215 18 as as IN cord-335975-m6lkrehi 5215 19 severity severity NN cord-335975-m6lkrehi 5215 20 general general JJ cord-335975-m6lkrehi 5215 21 scores score NNS cord-335975-m6lkrehi 5215 22 , , , cord-335975-m6lkrehi 5215 23 hemodynamic hemodynamic JJ cord-335975-m6lkrehi 5215 24 state state NN cord-335975-m6lkrehi 5215 25 and and CC cord-335975-m6lkrehi 5215 26 initial initial JJ cord-335975-m6lkrehi 5215 27 lumbar lumbar NN cord-335975-m6lkrehi 5215 28 puncture puncture NN cord-335975-m6lkrehi 5215 29 data datum NNS cord-335975-m6lkrehi 5215 30 . . . cord-335975-m6lkrehi 5216 1 We -PRON- PRP cord-335975-m6lkrehi 5216 2 will will MD cord-335975-m6lkrehi 5216 3 need need VB cord-335975-m6lkrehi 5216 4 more more JJR cord-335975-m6lkrehi 5216 5 investigations investigation NNS cord-335975-m6lkrehi 5216 6 and and CC cord-335975-m6lkrehi 5216 7 prospective prospective JJ cord-335975-m6lkrehi 5216 8 multicentric multicentric NN cord-335975-m6lkrehi 5216 9 study study NN cord-335975-m6lkrehi 5216 10 to to TO cord-335975-m6lkrehi 5216 11 have have VB cord-335975-m6lkrehi 5216 12 more more JJR cord-335975-m6lkrehi 5216 13 discrimination discrimination NN cord-335975-m6lkrehi 5216 14 parameters parameter NNS cord-335975-m6lkrehi 5216 15 . . . cord-335975-m6lkrehi 5217 1 Introduction introduction NN cord-335975-m6lkrehi 5217 2 : : : cord-335975-m6lkrehi 5218 1 The the DT cord-335975-m6lkrehi 5218 2 emergence emergence NN cord-335975-m6lkrehi 5218 3 of of IN cord-335975-m6lkrehi 5218 4 ATB ATB NNP cord-335975-m6lkrehi 5218 5 - - HYPH cord-335975-m6lkrehi 5218 6 resistant resistant JJ cord-335975-m6lkrehi 5218 7 bacteria bacteria NNS cord-335975-m6lkrehi 5218 8 has have VBZ cord-335975-m6lkrehi 5218 9 become become VBN cord-335975-m6lkrehi 5218 10 an an DT cord-335975-m6lkrehi 5218 11 important important JJ cord-335975-m6lkrehi 5218 12 public public JJ cord-335975-m6lkrehi 5218 13 health health NN cord-335975-m6lkrehi 5218 14 problem problem NN cord-335975-m6lkrehi 5218 15 , , , cord-335975-m6lkrehi 5218 16 particularly particularly RB cord-335975-m6lkrehi 5218 17 in in IN cord-335975-m6lkrehi 5218 18 resuscitation resuscitation NN cord-335975-m6lkrehi 5218 19 environments environment NNS cord-335975-m6lkrehi 5218 20 , , , cord-335975-m6lkrehi 5218 21 surveillance surveillance NN cord-335975-m6lkrehi 5218 22 and and CC cord-335975-m6lkrehi 5218 23 monitoring monitoring NN cord-335975-m6lkrehi 5218 24 of of IN cord-335975-m6lkrehi 5218 25 ATB ATB NNP cord-335975-m6lkrehi 5218 26 consumption consumption NN cord-335975-m6lkrehi 5218 27 is be VBZ cord-335975-m6lkrehi 5218 28 essential essential JJ cord-335975-m6lkrehi 5218 29 to to TO cord-335975-m6lkrehi 5218 30 combat combat VB cord-335975-m6lkrehi 5218 31 this this DT cord-335975-m6lkrehi 5218 32 threat threat NN cord-335975-m6lkrehi 5218 33 ecologically ecologically RB cord-335975-m6lkrehi 5218 34 and and CC cord-335975-m6lkrehi 5218 35 economically economically RB cord-335975-m6lkrehi 5218 36 . . . cord-335975-m6lkrehi 5219 1 The the DT cord-335975-m6lkrehi 5219 2 aim aim NN cord-335975-m6lkrehi 5219 3 of of IN cord-335975-m6lkrehi 5219 4 this this DT cord-335975-m6lkrehi 5219 5 work work NN cord-335975-m6lkrehi 5219 6 was be VBD cord-335975-m6lkrehi 5219 7 to to TO cord-335975-m6lkrehi 5219 8 evaluate evaluate VB cord-335975-m6lkrehi 5219 9 the the DT cord-335975-m6lkrehi 5219 10 consumption consumption NN cord-335975-m6lkrehi 5219 11 of of IN cord-335975-m6lkrehi 5219 12 ATB ATB NNP cord-335975-m6lkrehi 5219 13 in in IN cord-335975-m6lkrehi 5219 14 surgical surgical JJ cord-335975-m6lkrehi 5219 15 resuscitation resuscitation NN cord-335975-m6lkrehi 5219 16 , , , cord-335975-m6lkrehi 5219 17 to to TO cord-335975-m6lkrehi 5219 18 establish establish VB cord-335975-m6lkrehi 5219 19 the the DT cord-335975-m6lkrehi 5219 20 cost cost NN cord-335975-m6lkrehi 5219 21 , , , cord-335975-m6lkrehi 5219 22 and and CC cord-335975-m6lkrehi 5219 23 to to TO cord-335975-m6lkrehi 5219 24 list list VB cord-335975-m6lkrehi 5219 25 the the DT cord-335975-m6lkrehi 5219 26 risk risk NN cord-335975-m6lkrehi 5219 27 factors factor NNS cord-335975-m6lkrehi 5219 28 for for IN cord-335975-m6lkrehi 5219 29 bacterial bacterial JJ cord-335975-m6lkrehi 5219 30 resistance resistance NN cord-335975-m6lkrehi 5219 31 . . . cord-335975-m6lkrehi 5220 1 Patients patient NNS cord-335975-m6lkrehi 5220 2 and and CC cord-335975-m6lkrehi 5220 3 methods method NNS cord-335975-m6lkrehi 5220 4 : : : cord-335975-m6lkrehi 5220 5 It -PRON- PRP cord-335975-m6lkrehi 5220 6 is be VBZ cord-335975-m6lkrehi 5220 7 a a DT cord-335975-m6lkrehi 5220 8 retrospective retrospective JJ cord-335975-m6lkrehi 5220 9 analytical analytical JJ cord-335975-m6lkrehi 5220 10 study study NN cord-335975-m6lkrehi 5220 11 spread spread VBD cord-335975-m6lkrehi 5220 12 over over IN cord-335975-m6lkrehi 5220 13 1 1 CD cord-335975-m6lkrehi 5220 14 year year NN cord-335975-m6lkrehi 5220 15 , , , cord-335975-m6lkrehi 5220 16 studying study VBG cord-335975-m6lkrehi 5220 17 225 225 CD cord-335975-m6lkrehi 5220 18 patients patient NNS cord-335975-m6lkrehi 5220 19 who who WP cord-335975-m6lkrehi 5220 20 have have VBP cord-335975-m6lkrehi 5220 21 received receive VBN cord-335975-m6lkrehi 5220 22 antibiotic antibiotic JJ cord-335975-m6lkrehi 5220 23 therapy therapy NN cord-335975-m6lkrehi 5220 24 , , , cord-335975-m6lkrehi 5220 25 the the DT cord-335975-m6lkrehi 5220 26 data datum NNS cord-335975-m6lkrehi 5220 27 on on IN cord-335975-m6lkrehi 5220 28 the the DT cord-335975-m6lkrehi 5220 29 consumption consumption NN cord-335975-m6lkrehi 5220 30 of of IN cord-335975-m6lkrehi 5220 31 ATB ATB NNP cord-335975-m6lkrehi 5220 32 were be VBD cord-335975-m6lkrehi 5220 33 collected collect VBN cord-335975-m6lkrehi 5220 34 from from IN cord-335975-m6lkrehi 5220 35 the the DT cord-335975-m6lkrehi 5220 36 patient patient NN cord-335975-m6lkrehi 5220 37 's 's POS cord-335975-m6lkrehi 5220 38 medical medical JJ cord-335975-m6lkrehi 5220 39 records record NNS cord-335975-m6lkrehi 5220 40 , , , cord-335975-m6lkrehi 5220 41 the the DT cord-335975-m6lkrehi 5220 42 delivered deliver VBN cord-335975-m6lkrehi 5220 43 doses dose NNS cord-335975-m6lkrehi 5220 44 were be VBD cord-335975-m6lkrehi 5220 45 converted convert VBN cord-335975-m6lkrehi 5220 46 into into IN cord-335975-m6lkrehi 5220 47 DDD DDD NNP cord-335975-m6lkrehi 5220 48 , , , cord-335975-m6lkrehi 5220 49 according accord VBG cord-335975-m6lkrehi 5220 50 to to IN cord-335975-m6lkrehi 5220 51 The the DT cord-335975-m6lkrehi 5220 52 WHO WHO NNP cord-335975-m6lkrehi 5220 53 standards standard NNS cord-335975-m6lkrehi 5220 54 and and CC cord-335975-m6lkrehi 5220 55 the the DT cord-335975-m6lkrehi 5220 56 end end NN cord-335975-m6lkrehi 5220 57 result result NN cord-335975-m6lkrehi 5220 58 is be VBZ cord-335975-m6lkrehi 5220 59 expressed express VBN cord-335975-m6lkrehi 5220 60 in in IN cord-335975-m6lkrehi 5220 61 DDD DDD NNP cord-335975-m6lkrehi 5220 62 1000 1000 CD cord-335975-m6lkrehi 5220 63 days day NNS cord-335975-m6lkrehi 5220 64 of of IN cord-335975-m6lkrehi 5220 65 hospitalization hospitalization NN cord-335975-m6lkrehi 5220 66 . . . cord-335975-m6lkrehi 5221 1 The the DT cord-335975-m6lkrehi 5221 2 statistical statistical JJ cord-335975-m6lkrehi 5221 3 analysis analysis NN cord-335975-m6lkrehi 5221 4 was be VBD cord-335975-m6lkrehi 5221 5 carried carry VBN cord-335975-m6lkrehi 5221 6 out out RP cord-335975-m6lkrehi 5221 7 by by IN cord-335975-m6lkrehi 5221 8 the the DT cord-335975-m6lkrehi 5221 9 SPSS SPSS NNP cord-335975-m6lkrehi 5221 10 16 16 CD cord-335975-m6lkrehi 5221 11 software software NN cord-335975-m6lkrehi 5221 12 . . . cord-335975-m6lkrehi 5222 1 Results result NNS cord-335975-m6lkrehi 5222 2 : : : cord-335975-m6lkrehi 5223 1 In in IN cord-335975-m6lkrehi 5223 2 our -PRON- PRP$ cord-335975-m6lkrehi 5223 3 study study NN cord-335975-m6lkrehi 5223 4 , , , cord-335975-m6lkrehi 5223 5 the the DT cord-335975-m6lkrehi 5223 6 mean mean JJ cord-335975-m6lkrehi 5223 7 age age NN cord-335975-m6lkrehi 5223 8 was be VBD cord-335975-m6lkrehi 5223 9 43.15 43.15 CD cord-335975-m6lkrehi 5223 10 ± ± CD cord-335975-m6lkrehi 5223 11 5.5 5.5 CD cord-335975-m6lkrehi 5223 12 , , , cord-335975-m6lkrehi 5223 13 with with IN cord-335975-m6lkrehi 5223 14 male male JJ cord-335975-m6lkrehi 5223 15 predominance predominance NN cord-335975-m6lkrehi 5223 16 + + CC cord-335975-m6lkrehi 5223 17 Sex sex NN cord-335975-m6lkrehi 5223 18 ratio ratio NN cord-335975-m6lkrehi 5223 19 1.71 1.71 CD cord-335975-m6lkrehi 5224 1 , , , cord-335975-m6lkrehi 5224 2 traumatic traumatic JJ cord-335975-m6lkrehi 5224 3 pathology pathology NN cord-335975-m6lkrehi 5224 4 is be VBZ cord-335975-m6lkrehi 5224 5 the the DT cord-335975-m6lkrehi 5224 6 most most RBS cord-335975-m6lkrehi 5224 7 common common JJ cord-335975-m6lkrehi 5224 8 reason reason NN cord-335975-m6lkrehi 5224 9 for for IN cord-335975-m6lkrehi 5224 10 admission admission NN cord-335975-m6lkrehi 5224 11 , , , cord-335975-m6lkrehi 5224 12 pneumopathy pneumopathy NNP cord-335975-m6lkrehi 5224 13 was be VBD cord-335975-m6lkrehi 5224 14 the the DT cord-335975-m6lkrehi 5224 15 most most RBS cord-335975-m6lkrehi 5224 16 frequent frequent JJ cord-335975-m6lkrehi 5224 17 infection infection NN cord-335975-m6lkrehi 5224 18 . . . cord-335975-m6lkrehi 5225 1 Overall overall JJ cord-335975-m6lkrehi 5225 2 ATB ATB NNP cord-335975-m6lkrehi 5225 3 consumption consumption NN cord-335975-m6lkrehi 5225 4 was be VBD cord-335975-m6lkrehi 5225 5 1236.11 1236.11 CD cord-335975-m6lkrehi 5225 6 DDD DDD NNP cord-335975-m6lkrehi 5225 7 1000DH 1000dh CD cord-335975-m6lkrehi 5225 8 , , , cord-335975-m6lkrehi 5225 9 dominated dominate VBN cord-335975-m6lkrehi 5225 10 by by IN cord-335975-m6lkrehi 5225 11 the the DT cord-335975-m6lkrehi 5225 12 class class NN cord-335975-m6lkrehi 5225 13 of of IN cord-335975-m6lkrehi 5225 14 Betalactamins Betalactamins NNP cord-335975-m6lkrehi 5225 15 ( ( -LRB- cord-335975-m6lkrehi 5225 16 cephalosporins cephalosporin NNS cord-335975-m6lkrehi 5225 17 166.89 166.89 CD cord-335975-m6lkrehi 5225 18 DDD DDD NNP cord-335975-m6lkrehi 5225 19 1000DH 1000dh CD cord-335975-m6lkrehi 5225 20 , , , cord-335975-m6lkrehi 5225 21 carbapenemes carbapenemes NNP cord-335975-m6lkrehi 5225 22 179.68 179.68 CD cord-335975-m6lkrehi 5225 23 DDD DDD NNP cord-335975-m6lkrehi 5225 24 1000DH 1000dh CD cord-335975-m6lkrehi 5225 25 ) ) -RRB- cord-335975-m6lkrehi 5225 26 , , , cord-335975-m6lkrehi 5225 27 the the DT cord-335975-m6lkrehi 5225 28 direct direct JJ cord-335975-m6lkrehi 5225 29 cost cost NN cord-335975-m6lkrehi 5225 30 of of IN cord-335975-m6lkrehi 5225 31 ATBs atb NNS cord-335975-m6lkrehi 5225 32 rises rise VBZ cord-335975-m6lkrehi 5225 33 to to IN cord-335975-m6lkrehi 5225 34 0.33 0.33 CD cord-335975-m6lkrehi 5225 35 million million CD cord-335975-m6lkrehi 5225 36 dirhams dirham NNS cord-335975-m6lkrehi 5225 37 , , , cord-335975-m6lkrehi 5225 38 these these DT cord-335975-m6lkrehi 5225 39 are be VBP cord-335975-m6lkrehi 5225 40 accounting account VBG cord-335975-m6lkrehi 5225 41 for for IN cord-335975-m6lkrehi 5225 42 a a DT cord-335975-m6lkrehi 5225 43 large large JJ cord-335975-m6lkrehi 5225 44 part part NN cord-335975-m6lkrehi 5225 45 of of IN cord-335975-m6lkrehi 5225 46 the the DT cord-335975-m6lkrehi 5225 47 pharmaceutical pharmaceutical JJ cord-335975-m6lkrehi 5225 48 budget budget NN cord-335975-m6lkrehi 5225 49 of of IN cord-335975-m6lkrehi 5225 50 the the DT cord-335975-m6lkrehi 5225 51 Ibn Ibn NNP cord-335975-m6lkrehi 5225 52 Rochd Rochd NNP cord-335975-m6lkrehi 5225 53 University University NNP cord-335975-m6lkrehi 5225 54 Hospital Hospital NNP cord-335975-m6lkrehi 5225 55 . . . cord-335975-m6lkrehi 5226 1 Bacteria Bacteria NNS cord-335975-m6lkrehi 5226 2 found find VBN cord-335975-m6lkrehi 5226 3 in in IN cord-335975-m6lkrehi 5226 4 order order NN cord-335975-m6lkrehi 5226 5 of of IN cord-335975-m6lkrehi 5226 6 frequency frequency NN cord-335975-m6lkrehi 5226 7 were be VBD cord-335975-m6lkrehi 5226 8 Acinetobacter Acinetobacter NNP cord-335975-m6lkrehi 5226 9 baummanii baummanii NNP cord-335975-m6lkrehi 5226 10 , , , cord-335975-m6lkrehi 5226 11 beta beta NN cord-335975-m6lkrehi 5226 12 - - HYPH cord-335975-m6lkrehi 5226 13 lactamaseproducing lactamaseproduce VBG cord-335975-m6lkrehi 5226 14 enterobacteria enterobacteria NN cord-335975-m6lkrehi 5226 15 , , , cord-335975-m6lkrehi 5226 16 S. S. NNP cord-335975-m6lkrehi 5226 17 aureus aureus NN cord-335975-m6lkrehi 5226 18 and and CC cord-335975-m6lkrehi 5226 19 P. P. NNP cord-335975-m6lkrehi 5226 20 aeruginosa aeruginosa NN cord-335975-m6lkrehi 5226 21 . . . cord-335975-m6lkrehi 5227 1 Acinetobacter Acinetobacter NNP cord-335975-m6lkrehi 5227 2 baumannii baumannii NNP cord-335975-m6lkrehi 5227 3 showed show VBD cord-335975-m6lkrehi 5227 4 the the DT cord-335975-m6lkrehi 5227 5 highest high JJS cord-335975-m6lkrehi 5227 6 resistance resistance NN cord-335975-m6lkrehi 5227 7 rate rate NN cord-335975-m6lkrehi 5227 8 . . . cord-335975-m6lkrehi 5228 1 Several several JJ cord-335975-m6lkrehi 5228 2 risk risk NN cord-335975-m6lkrehi 5228 3 factors factor NNS cord-335975-m6lkrehi 5228 4 for for IN cord-335975-m6lkrehi 5228 5 bacterial bacterial JJ cord-335975-m6lkrehi 5228 6 resistance resistance NN cord-335975-m6lkrehi 5228 7 were be VBD cord-335975-m6lkrehi 5228 8 studied study VBN cord-335975-m6lkrehi 5228 9 , , , cord-335975-m6lkrehi 5228 10 notably notably RB cord-335975-m6lkrehi 5228 11 the the DT cord-335975-m6lkrehi 5228 12 correlation correlation NN cord-335975-m6lkrehi 5228 13 between between IN cord-335975-m6lkrehi 5228 14 the the DT cord-335975-m6lkrehi 5228 15 use use NN cord-335975-m6lkrehi 5228 16 of of IN cord-335975-m6lkrehi 5228 17 ATB ATB NNP cord-335975-m6lkrehi 5228 18 and and CC cord-335975-m6lkrehi 5228 19 the the DT cord-335975-m6lkrehi 5228 20 emergence emergence NN cord-335975-m6lkrehi 5228 21 of of IN cord-335975-m6lkrehi 5228 22 resistant resistant JJ cord-335975-m6lkrehi 5228 23 strains strain NNS cord-335975-m6lkrehi 5228 24 , , , cord-335975-m6lkrehi 5228 25 only only RB cord-335975-m6lkrehi 5228 26 piperacillintazobactam piperacillintazobactam NNP cord-335975-m6lkrehi 5228 27 was be VBD cord-335975-m6lkrehi 5228 28 associated associate VBN cord-335975-m6lkrehi 5228 29 with with IN cord-335975-m6lkrehi 5228 30 the the DT cord-335975-m6lkrehi 5228 31 emergence emergence NN cord-335975-m6lkrehi 5228 32 of of IN cord-335975-m6lkrehi 5228 33 resistant resistant JJ cord-335975-m6lkrehi 5228 34 strains strain NNS cord-335975-m6lkrehi 5228 35 of of IN cord-335975-m6lkrehi 5228 36 EBLSE EBLSE NNP cord-335975-m6lkrehi 5228 37 , , , cord-335975-m6lkrehi 5228 38 as as RB cord-335975-m6lkrehi 5228 39 well well RB cord-335975-m6lkrehi 5228 40 as as IN cord-335975-m6lkrehi 5228 41 2 2 CD cord-335975-m6lkrehi 5228 42 other other JJ cord-335975-m6lkrehi 5228 43 factors factor NNS cord-335975-m6lkrehi 5228 44 that that WDT cord-335975-m6lkrehi 5228 45 were be VBD cord-335975-m6lkrehi 5228 46 retained retain VBN cord-335975-m6lkrehi 5228 47 as as IN cord-335975-m6lkrehi 5228 48 significantly significantly RB cord-335975-m6lkrehi 5228 49 related relate VBN cord-335975-m6lkrehi 5228 50 to to IN cord-335975-m6lkrehi 5228 51 bacterial bacterial JJ cord-335975-m6lkrehi 5228 52 resistance resistance NN cord-335975-m6lkrehi 5228 53 by by IN cord-335975-m6lkrehi 5228 54 multivariate multivariate JJ cord-335975-m6lkrehi 5228 55 analysis analysis NN cord-335975-m6lkrehi 5228 56 - - HYPH cord-335975-m6lkrehi 5228 57 duration duration NN cord-335975-m6lkrehi 5228 58 of of IN cord-335975-m6lkrehi 5228 59 hospitalization hospitalization NN cord-335975-m6lkrehi 5228 60 and and CC cord-335975-m6lkrehi 5228 61 perfusion perfusion NN cord-335975-m6lkrehi 5228 62 of of IN cord-335975-m6lkrehi 5228 63 albumin albumin NN cord-335975-m6lkrehi 5228 64 . . . cord-335975-m6lkrehi 5229 1 Discussion discussion NN cord-335975-m6lkrehi 5229 2 : : : cord-335975-m6lkrehi 5230 1 Despite despite IN cord-335975-m6lkrehi 5230 2 the the DT cord-335975-m6lkrehi 5230 3 limited limited JJ cord-335975-m6lkrehi 5230 4 number number NN cord-335975-m6lkrehi 5230 5 of of IN cord-335975-m6lkrehi 5230 6 studies study NNS cord-335975-m6lkrehi 5230 7 done do VBN cord-335975-m6lkrehi 5230 8 on on IN cord-335975-m6lkrehi 5230 9 ATB ATB NNP cord-335975-m6lkrehi 5230 10 consumption consumption NN cord-335975-m6lkrehi 5230 11 , , , cord-335975-m6lkrehi 5230 12 it -PRON- PRP cord-335975-m6lkrehi 5230 13 seemed seem VBD cord-335975-m6lkrehi 5230 14 that that IN cord-335975-m6lkrehi 5230 15 our -PRON- PRP$ cord-335975-m6lkrehi 5230 16 results result NNS cord-335975-m6lkrehi 5230 17 were be VBD cord-335975-m6lkrehi 5230 18 similar similar JJ cord-335975-m6lkrehi 5230 19 to to IN cord-335975-m6lkrehi 5230 20 other other JJ cord-335975-m6lkrehi 5230 21 national national JJ cord-335975-m6lkrehi 5230 22 and and CC cord-335975-m6lkrehi 5230 23 foreign foreign JJ cord-335975-m6lkrehi 5230 24 studies study NNS cord-335975-m6lkrehi 5230 25 , , , cord-335975-m6lkrehi 5230 26 the the DT cord-335975-m6lkrehi 5230 27 consumption consumption NN cord-335975-m6lkrehi 5230 28 of of IN cord-335975-m6lkrehi 5230 29 ATBs atb NNS cord-335975-m6lkrehi 5230 30 is be VBZ cord-335975-m6lkrehi 5230 31 increased increase VBN cord-335975-m6lkrehi 5230 32 in in IN cord-335975-m6lkrehi 5230 33 hospital hospital NN cord-335975-m6lkrehi 5230 34 giving giving NN cord-335975-m6lkrehi 5230 35 rise rise NN cord-335975-m6lkrehi 5230 36 to to IN cord-335975-m6lkrehi 5230 37 the the DT cord-335975-m6lkrehi 5230 38 appearance appearance NN cord-335975-m6lkrehi 5230 39 of of IN cord-335975-m6lkrehi 5230 40 many many JJ cord-335975-m6lkrehi 5230 41 multi multi JJ cord-335975-m6lkrehi 5230 42 - - JJ cord-335975-m6lkrehi 5230 43 resistant resistant JJ cord-335975-m6lkrehi 5230 44 bacteria bacteria NNS cord-335975-m6lkrehi 5230 45 . . . cord-335975-m6lkrehi 5231 1 Conclusion conclusion NN cord-335975-m6lkrehi 5231 2 : : : cord-335975-m6lkrehi 5232 1 In in IN cord-335975-m6lkrehi 5232 2 conclusion conclusion NN cord-335975-m6lkrehi 5232 3 , , , cord-335975-m6lkrehi 5232 4 resistance resistance NN cord-335975-m6lkrehi 5232 5 to to IN cord-335975-m6lkrehi 5232 6 antibiotics antibiotic NNS cord-335975-m6lkrehi 5232 7 is be VBZ cord-335975-m6lkrehi 5232 8 a a DT cord-335975-m6lkrehi 5232 9 serious serious JJ cord-335975-m6lkrehi 5232 10 threat threat NN cord-335975-m6lkrehi 5232 11 to to IN cord-335975-m6lkrehi 5232 12 public public JJ cord-335975-m6lkrehi 5232 13 health health NN cord-335975-m6lkrehi 5232 14 both both CC cord-335975-m6lkrehi 5232 15 nationally nationally RB cord-335975-m6lkrehi 5232 16 and and CC cord-335975-m6lkrehi 5232 17 globally globally RB cord-335975-m6lkrehi 5232 18 . . . cord-335975-m6lkrehi 5233 1 It -PRON- PRP cord-335975-m6lkrehi 5233 2 is be VBZ cord-335975-m6lkrehi 5233 3 therefore therefore RB cord-335975-m6lkrehi 5233 4 crucial crucial JJ cord-335975-m6lkrehi 5233 5 to to TO cord-335975-m6lkrehi 5233 6 implement implement VB cord-335975-m6lkrehi 5233 7 measures measure NNS cord-335975-m6lkrehi 5233 8 to to TO cord-335975-m6lkrehi 5233 9 counter counter VB cord-335975-m6lkrehi 5233 10 this this DT cord-335975-m6lkrehi 5233 11 phenomenon phenomenon NN cord-335975-m6lkrehi 5233 12 + + CC cord-335975-m6lkrehi 5233 13 this this DT cord-335975-m6lkrehi 5233 14 is be VBZ cord-335975-m6lkrehi 5233 15 only only RB cord-335975-m6lkrehi 5233 16 possible possible JJ cord-335975-m6lkrehi 5233 17 through through IN cord-335975-m6lkrehi 5233 18 the the DT cord-335975-m6lkrehi 5233 19 proper proper JJ cord-335975-m6lkrehi 5233 20 use use NN cord-335975-m6lkrehi 5233 21 of of IN cord-335975-m6lkrehi 5233 22 ATBs atb NNS cord-335975-m6lkrehi 5233 23 and and CC cord-335975-m6lkrehi 5233 24 gaits gait NNS cord-335975-m6lkrehi 5233 25 to to TO cord-335975-m6lkrehi 5233 26 prevent prevent VB cord-335975-m6lkrehi 5233 27 nosocomial nosocomial JJ cord-335975-m6lkrehi 5233 28 infections infection NNS cord-335975-m6lkrehi 5233 29 . . . cord-335975-m6lkrehi 5234 1 Introduction introduction NN cord-335975-m6lkrehi 5234 2 : : : cord-335975-m6lkrehi 5235 1 Ventilaor Ventilaor NNP cord-335975-m6lkrehi 5235 2 - - HYPH cord-335975-m6lkrehi 5235 3 associated associate VBN cord-335975-m6lkrehi 5235 4 pneumonia pneumonia NN cord-335975-m6lkrehi 5235 5 ( ( -LRB- cord-335975-m6lkrehi 5235 6 VAP VAP NNP cord-335975-m6lkrehi 5235 7 ) ) -RRB- cord-335975-m6lkrehi 5235 8 , , , cord-335975-m6lkrehi 5235 9 the the DT cord-335975-m6lkrehi 5235 10 leading lead VBG cord-335975-m6lkrehi 5235 11 cause cause NN cord-335975-m6lkrehi 5235 12 of of IN cord-335975-m6lkrehi 5235 13 infection infection NN cord-335975-m6lkrehi 5235 14 in in IN cord-335975-m6lkrehi 5235 15 resuscitation resuscitation NN cord-335975-m6lkrehi 5235 16 , , , cord-335975-m6lkrehi 5235 17 is be VBZ cord-335975-m6lkrehi 5235 18 also also RB cord-335975-m6lkrehi 5235 19 the the DT cord-335975-m6lkrehi 5235 20 main main JJ cord-335975-m6lkrehi 5235 21 respiratory respiratory JJ cord-335975-m6lkrehi 5235 22 complication complication NN cord-335975-m6lkrehi 5235 23 in in IN cord-335975-m6lkrehi 5235 24 cranial cranial JJ cord-335975-m6lkrehi 5235 25 trauma trauma NN cord-335975-m6lkrehi 5235 26 . . . cord-335975-m6lkrehi 5236 1 The the DT cord-335975-m6lkrehi 5236 2 aim aim NN cord-335975-m6lkrehi 5236 3 of of IN cord-335975-m6lkrehi 5236 4 this this DT cord-335975-m6lkrehi 5236 5 study study NN cord-335975-m6lkrehi 5236 6 is be VBZ cord-335975-m6lkrehi 5236 7 to to TO cord-335975-m6lkrehi 5236 8 determine determine VB cord-335975-m6lkrehi 5236 9 the the DT cord-335975-m6lkrehi 5236 10 specific specific JJ cord-335975-m6lkrehi 5236 11 risk risk NN cord-335975-m6lkrehi 5236 12 factors factor NNS cord-335975-m6lkrehi 5236 13 for for IN cord-335975-m6lkrehi 5236 14 the the DT cord-335975-m6lkrehi 5236 15 occurrence occurrence NN cord-335975-m6lkrehi 5236 16 of of IN cord-335975-m6lkrehi 5236 17 VAP VAP NNP cord-335975-m6lkrehi 5236 18 in in IN cord-335975-m6lkrehi 5236 19 this this DT cord-335975-m6lkrehi 5236 20 type type NN cord-335975-m6lkrehi 5236 21 of of IN cord-335975-m6lkrehi 5236 22 patient patient NN cord-335975-m6lkrehi 5236 23 in in IN cord-335975-m6lkrehi 5236 24 an an DT cord-335975-m6lkrehi 5236 25 intensive intensive JJ cord-335975-m6lkrehi 5236 26 care care NN cord-335975-m6lkrehi 5236 27 unit unit NN cord-335975-m6lkrehi 5236 28 . . . cord-335975-m6lkrehi 5237 1 Patients patient NNS cord-335975-m6lkrehi 5237 2 and and CC cord-335975-m6lkrehi 5237 3 methods method NNS cord-335975-m6lkrehi 5237 4 : : : cord-335975-m6lkrehi 5237 5 We -PRON- PRP cord-335975-m6lkrehi 5237 6 performed perform VBD cord-335975-m6lkrehi 5237 7 a a DT cord-335975-m6lkrehi 5237 8 retrospective retrospective JJ cord-335975-m6lkrehi 5237 9 study study NN cord-335975-m6lkrehi 5237 10 in in IN cord-335975-m6lkrehi 5237 11 our -PRON- PRP$ cord-335975-m6lkrehi 5237 12 intensive intensive JJ cord-335975-m6lkrehi 5237 13 care care NN cord-335975-m6lkrehi 5237 14 unit unit NN cord-335975-m6lkrehi 5237 15 for for IN cord-335975-m6lkrehi 5237 16 an an DT cord-335975-m6lkrehi 5237 17 18-month 18-month JJ cord-335975-m6lkrehi 5237 18 period period NN cord-335975-m6lkrehi 5237 19 ( ( -LRB- cord-335975-m6lkrehi 5237 20 January January NNP cord-335975-m6lkrehi 5237 21 2016 2016 CD cord-335975-m6lkrehi 5237 22 , , , cord-335975-m6lkrehi 5237 23 June June NNP cord-335975-m6lkrehi 5237 24 2017 2017 CD cord-335975-m6lkrehi 5237 25 ) ) -RRB- cord-335975-m6lkrehi 5237 26 . . . cord-335975-m6lkrehi 5238 1 All all DT cord-335975-m6lkrehi 5238 2 patients patient NNS cord-335975-m6lkrehi 5238 3 admitted admit VBD cord-335975-m6lkrehi 5238 4 for for IN cord-335975-m6lkrehi 5238 5 cranial cranial JJ cord-335975-m6lkrehi 5238 6 trauma trauma NN cord-335975-m6lkrehi 5238 7 were be VBD cord-335975-m6lkrehi 5238 8 included include VBN cord-335975-m6lkrehi 5238 9 in in IN cord-335975-m6lkrehi 5238 10 the the DT cord-335975-m6lkrehi 5238 11 study study NN cord-335975-m6lkrehi 5238 12 and and CC cord-335975-m6lkrehi 5238 13 ventilated ventilate VBD cord-335975-m6lkrehi 5238 14 more more JJR cord-335975-m6lkrehi 5238 15 than than IN cord-335975-m6lkrehi 5238 16 48 48 CD cord-335975-m6lkrehi 5238 17 h h NN cord-335975-m6lkrehi 5238 18 in in IN cord-335975-m6lkrehi 5238 19 intensive intensive JJ cord-335975-m6lkrehi 5238 20 care care NN cord-335975-m6lkrehi 5238 21 . . . cord-335975-m6lkrehi 5239 1 VAP VAP NNP cord-335975-m6lkrehi 5239 2 is be VBZ cord-335975-m6lkrehi 5239 3 defined define VBN cord-335975-m6lkrehi 5239 4 as as RB cord-335975-m6lkrehi 5239 5 late late RB cord-335975-m6lkrehi 5239 6 as as IN cord-335975-m6lkrehi 5239 7 of of IN cord-335975-m6lkrehi 5239 8 the the DT cord-335975-m6lkrehi 5239 9 5th 5th JJ cord-335975-m6lkrehi 5239 10 day day NN cord-335975-m6lkrehi 5239 11 of of IN cord-335975-m6lkrehi 5239 12 occurrence occurrence NN cord-335975-m6lkrehi 5239 13 . . . cord-335975-m6lkrehi 5240 1 The the DT cord-335975-m6lkrehi 5240 2 quantitative quantitative JJ cord-335975-m6lkrehi 5240 3 and and CC cord-335975-m6lkrehi 5240 4 qualitative qualitative JJ cord-335975-m6lkrehi 5240 5 variables variable NNS cord-335975-m6lkrehi 5240 6 studied study VBN cord-335975-m6lkrehi 5240 7 were be VBD cord-335975-m6lkrehi 5240 8 recorded record VBN cord-335975-m6lkrehi 5240 9 at at IN cord-335975-m6lkrehi 5240 10 admission admission NN cord-335975-m6lkrehi 5240 11 and and CC cord-335975-m6lkrehi 5240 12 during during IN cord-335975-m6lkrehi 5240 13 hospitalization hospitalization NN cord-335975-m6lkrehi 5240 14 . . . cord-335975-m6lkrehi 5241 1 A a DT cord-335975-m6lkrehi 5241 2 univariate univariate JJ cord-335975-m6lkrehi 5241 3 and and CC cord-335975-m6lkrehi 5241 4 multivariate multivariate JJ cord-335975-m6lkrehi 5241 5 analysis analysis NN cord-335975-m6lkrehi 5241 6 using use VBG cord-335975-m6lkrehi 5241 7 the the DT cord-335975-m6lkrehi 5241 8 Fischer Fischer NNP cord-335975-m6lkrehi 5241 9 and and CC cord-335975-m6lkrehi 5241 10 Mann Mann NNP cord-335975-m6lkrehi 5241 11 - - HYPH cord-335975-m6lkrehi 5241 12 Whitney Whitney NNP cord-335975-m6lkrehi 5241 13 tests test NNS cord-335975-m6lkrehi 5241 14 was be VBD cord-335975-m6lkrehi 5241 15 performed perform VBN cord-335975-m6lkrehi 5241 16 . . . cord-335975-m6lkrehi 5242 1 p p NN cord-335975-m6lkrehi 5242 2 is be VBZ cord-335975-m6lkrehi 5242 3 said say VBN cord-335975-m6lkrehi 5242 4 to to TO cord-335975-m6lkrehi 5242 5 be be VB cord-335975-m6lkrehi 5242 6 significant significant JJ cord-335975-m6lkrehi 5242 7 if if IN cord-335975-m6lkrehi 5242 8 it -PRON- PRP cord-335975-m6lkrehi 5242 9 is be VBZ cord-335975-m6lkrehi 5242 10 < < XX cord-335975-m6lkrehi 5242 11 0.05 0.05 CD cord-335975-m6lkrehi 5242 12 . . . cord-335975-m6lkrehi 5243 1 Results result NNS cord-335975-m6lkrehi 5243 2 : : : cord-335975-m6lkrehi 5244 1 Our -PRON- PRP$ cord-335975-m6lkrehi 5244 2 study study NN cord-335975-m6lkrehi 5244 3 included include VBD cord-335975-m6lkrehi 5244 4 50 50 CD cord-335975-m6lkrehi 5244 5 traumatic traumatic JJ cord-335975-m6lkrehi 5244 6 brain brain NN cord-335975-m6lkrehi 5244 7 injury injury NN cord-335975-m6lkrehi 5244 8 in in IN cord-335975-m6lkrehi 5244 9 older old JJR cord-335975-m6lkrehi 5244 10 adults adult NNS cord-335975-m6lkrehi 5244 11 , , , cord-335975-m6lkrehi 5244 12 of of IN cord-335975-m6lkrehi 5244 13 whom whom WP cord-335975-m6lkrehi 5244 14 22 22 CD cord-335975-m6lkrehi 5244 15 ( ( -LRB- cord-335975-m6lkrehi 5244 16 44 44 CD cord-335975-m6lkrehi 5244 17 % % NN cord-335975-m6lkrehi 5244 18 ) ) -RRB- cord-335975-m6lkrehi 5244 19 had have VBD cord-335975-m6lkrehi 5244 20 one one CD cord-335975-m6lkrehi 5244 21 or or CC cord-335975-m6lkrehi 5244 22 more more JJR cord-335975-m6lkrehi 5244 23 episodes episode NNS cord-335975-m6lkrehi 5244 24 of of IN cord-335975-m6lkrehi 5244 25 VAP VAP NNP cord-335975-m6lkrehi 5244 26 during during IN cord-335975-m6lkrehi 5244 27 their -PRON- PRP$ cord-335975-m6lkrehi 5244 28 resuscitation resuscitation NN cord-335975-m6lkrehi 5244 29 . . . cord-335975-m6lkrehi 5245 1 Late Late NNP cord-335975-m6lkrehi 5245 2 VAP VAP NNP cord-335975-m6lkrehi 5245 3 accounted account VBD cord-335975-m6lkrehi 5245 4 for for IN cord-335975-m6lkrehi 5245 5 almost almost RB cord-335975-m6lkrehi 5245 6 2 2 CD cord-335975-m6lkrehi 5245 7 3 3 CD cord-335975-m6lkrehi 5245 8 of of IN cord-335975-m6lkrehi 5245 9 the the DT cord-335975-m6lkrehi 5245 10 cases case NNS cord-335975-m6lkrehi 5245 11 ( ( -LRB- cord-335975-m6lkrehi 5245 12 33 33 CD cord-335975-m6lkrehi 5245 13 patients patient NNS cord-335975-m6lkrehi 5245 14 ) ) -RRB- cord-335975-m6lkrehi 5245 15 . . . cord-335975-m6lkrehi 5246 1 Four four CD cord-335975-m6lkrehi 5246 2 independent independent JJ cord-335975-m6lkrehi 5246 3 variables variable NNS cord-335975-m6lkrehi 5246 4 were be VBD cord-335975-m6lkrehi 5246 5 significantly significantly RB cord-335975-m6lkrehi 5246 6 related relate VBN cord-335975-m6lkrehi 5246 7 to to IN cord-335975-m6lkrehi 5246 8 the the DT cord-335975-m6lkrehi 5246 9 occurrence occurrence NN cord-335975-m6lkrehi 5246 10 of of IN cord-335975-m6lkrehi 5246 11 VAP VAP NNP cord-335975-m6lkrehi 5246 12 - - HYPH cord-335975-m6lkrehi 5246 13 advanced advanced JJ cord-335975-m6lkrehi 5246 14 age age NN cord-335975-m6lkrehi 5246 15 ( ( -LRB- cord-335975-m6lkrehi 5246 16 p p NN cord-335975-m6lkrehi 5246 17 = = SYM cord-335975-m6lkrehi 5246 18 0.04 0.04 CD cord-335975-m6lkrehi 5246 19 ) ) -RRB- cord-335975-m6lkrehi 5246 20 , , , cord-335975-m6lkrehi 5246 21 Glasgow Glasgow NNP cord-335975-m6lkrehi 5246 22 score score NN cord-335975-m6lkrehi 5246 23 ( ( -LRB- cord-335975-m6lkrehi 5246 24 GCS GCS NNP cord-335975-m6lkrehi 5246 25 ) ) -RRB- cord-335975-m6lkrehi 5246 26 at at IN cord-335975-m6lkrehi 5246 27 admission admission NN cord-335975-m6lkrehi 5246 28 < < XX cord-335975-m6lkrehi 5246 29 8 8 CD cord-335975-m6lkrehi 5247 1 ( ( -LRB- cord-335975-m6lkrehi 5247 2 p p NN cord-335975-m6lkrehi 5247 3 = = SYM cord-335975-m6lkrehi 5247 4 0.01 0.01 CD cord-335975-m6lkrehi 5247 5 ) ) -RRB- cord-335975-m6lkrehi 5247 6 , , , cord-335975-m6lkrehi 5247 7 diabetes diabetes NN cord-335975-m6lkrehi 5247 8 ( ( -LRB- cord-335975-m6lkrehi 5247 9 p p NN cord-335975-m6lkrehi 5247 10 = = SYM cord-335975-m6lkrehi 5247 11 0 0 CD cord-335975-m6lkrehi 5247 12 , , , cord-335975-m6lkrehi 5247 13 03 03 CD cord-335975-m6lkrehi 5247 14 ) ) -RRB- cord-335975-m6lkrehi 5247 15 , , , cord-335975-m6lkrehi 5247 16 and and CC cord-335975-m6lkrehi 5247 17 the the DT cord-335975-m6lkrehi 5247 18 use use NN cord-335975-m6lkrehi 5247 19 of of IN cord-335975-m6lkrehi 5247 20 Proton Proton NNP cord-335975-m6lkrehi 5247 21 Pump Pump NNP cord-335975-m6lkrehi 5247 22 Inhibitors Inhibitors NNP cord-335975-m6lkrehi 5247 23 for for IN cord-335975-m6lkrehi 5247 24 the the DT cord-335975-m6lkrehi 5247 25 prevention prevention NN cord-335975-m6lkrehi 5247 26 of of IN cord-335975-m6lkrehi 5247 27 stress stress NN cord-335975-m6lkrehi 5247 28 ulcers ulcer NNS cord-335975-m6lkrehi 5247 29 ( ( -LRB- cord-335975-m6lkrehi 5247 30 p p NN cord-335975-m6lkrehi 5247 31 = = SYM cord-335975-m6lkrehi 5247 32 0.04 0.04 CD cord-335975-m6lkrehi 5247 33 ) ) -RRB- cord-335975-m6lkrehi 5247 34 . . . cord-335975-m6lkrehi 5248 1 The the DT cord-335975-m6lkrehi 5248 2 duration duration NN cord-335975-m6lkrehi 5248 3 of of IN cord-335975-m6lkrehi 5248 4 intubation intubation NN cord-335975-m6lkrehi 5248 5 ( ( -LRB- cord-335975-m6lkrehi 5248 6 18 18 CD cord-335975-m6lkrehi 5248 7 ± ± NNP cord-335975-m6lkrehi 5248 8 6 6 CD cord-335975-m6lkrehi 5248 9 vs. vs. NN cord-335975-m6lkrehi 5248 10 11 11 CD cord-335975-m6lkrehi 5248 11 ± ± CD cord-335975-m6lkrehi 5248 12 3 3 CD cord-335975-m6lkrehi 5248 13 days day NNS cord-335975-m6lkrehi 5248 14 ) ) -RRB- cord-335975-m6lkrehi 5248 15 and and CC cord-335975-m6lkrehi 5248 16 on on IN cord-335975-m6lkrehi 5248 17 intensive intensive JJ cord-335975-m6lkrehi 5248 18 care care NN cord-335975-m6lkrehi 5248 19 ( ( -LRB- cord-335975-m6lkrehi 5248 20 28 28 CD cord-335975-m6lkrehi 5248 21 ± ± NNP cord-335975-m6lkrehi 5248 22 16 16 CD cord-335975-m6lkrehi 5248 23 vs. vs. NN cord-335975-m6lkrehi 5248 24 15 15 CD cord-335975-m6lkrehi 5248 25 ± ± CD cord-335975-m6lkrehi 5248 26 3 3 CD cord-335975-m6lkrehi 5248 27 days day NNS cord-335975-m6lkrehi 5248 28 ) ) -RRB- cord-335975-m6lkrehi 5248 29 are be VBP cord-335975-m6lkrehi 5248 30 significantly significantly RB cord-335975-m6lkrehi 5248 31 longer long JJR cord-335975-m6lkrehi 5248 32 in in IN cord-335975-m6lkrehi 5248 33 the the DT cord-335975-m6lkrehi 5248 34 case case NN cord-335975-m6lkrehi 5248 35 of of IN cord-335975-m6lkrehi 5248 36 VAP VAP NNP cord-335975-m6lkrehi 5248 37 . . . cord-335975-m6lkrehi 5249 1 Mortality mortality NN cord-335975-m6lkrehi 5249 2 was be VBD cord-335975-m6lkrehi 5249 3 significantly significantly RB cord-335975-m6lkrehi 5249 4 higher high JJR cord-335975-m6lkrehi 5249 5 in in IN cord-335975-m6lkrehi 5249 6 VAP-45 VAP-45 NNP cord-335975-m6lkrehi 5249 7 versus versus IN cord-335975-m6lkrehi 5249 8 28 28 CD cord-335975-m6lkrehi 5249 9 % % NN cord-335975-m6lkrehi 5250 1 ( ( -LRB- cord-335975-m6lkrehi 5250 2 p p NN cord-335975-m6lkrehi 5250 3 = = SYM cord-335975-m6lkrehi 5250 4 0.01 0.01 CD cord-335975-m6lkrehi 5250 5 ) ) -RRB- cord-335975-m6lkrehi 5250 6 . . . cord-335975-m6lkrehi 5251 1 The the DT cord-335975-m6lkrehi 5251 2 majority majority NN cord-335975-m6lkrehi 5251 3 of of IN cord-335975-m6lkrehi 5251 4 early early JJ cord-335975-m6lkrehi 5251 5 VAP VAP NNP cord-335975-m6lkrehi 5251 6 were be VBD cord-335975-m6lkrehi 5251 7 due due JJ cord-335975-m6lkrehi 5251 8 to to IN cord-335975-m6lkrehi 5251 9 both both DT cord-335975-m6lkrehi 5251 10 Strepococcus Strepococcus NNP cord-335975-m6lkrehi 5251 11 ppneumoniae ppneumoniae NN cord-335975-m6lkrehi 5251 12 and and CC cord-335975-m6lkrehi 5251 13 Haemophilus haemophilus JJ cord-335975-m6lkrehi 5251 14 influenzae influenzae NN cord-335975-m6lkrehi 5251 15 . . . cord-335975-m6lkrehi 5252 1 The the DT cord-335975-m6lkrehi 5252 2 ecology ecology NN cord-335975-m6lkrehi 5252 3 of of IN cord-335975-m6lkrehi 5252 4 late late JJ cord-335975-m6lkrehi 5252 5 VAP VAP NNP cord-335975-m6lkrehi 5252 6 was be VBD cord-335975-m6lkrehi 5252 7 dominated dominate VBN cord-335975-m6lkrehi 5252 8 by by IN cord-335975-m6lkrehi 5252 9 Klebsiella Klebsiella NNP cord-335975-m6lkrehi 5252 10 pneumoniae pneumoniae NN cord-335975-m6lkrehi 5252 11 , , , cord-335975-m6lkrehi 5252 12 Pseudomonas Pseudomonas NNP cord-335975-m6lkrehi 5252 13 aeruginosa aeruginosa NN cord-335975-m6lkrehi 5252 14 and and CC cord-335975-m6lkrehi 5252 15 acinetobacter acinetobacter NNP cord-335975-m6lkrehi 5252 16 baumanii baumanii NNP cord-335975-m6lkrehi 5252 17 . . . cord-335975-m6lkrehi 5253 1 Conclusion conclusion NN cord-335975-m6lkrehi 5253 2 : : : cord-335975-m6lkrehi 5253 3 Of of IN cord-335975-m6lkrehi 5253 4 the the DT cord-335975-m6lkrehi 5253 5 four four CD cord-335975-m6lkrehi 5253 6 independent independent JJ cord-335975-m6lkrehi 5253 7 risk risk NN cord-335975-m6lkrehi 5253 8 factors factor NNS cord-335975-m6lkrehi 5253 9 found find VBN cord-335975-m6lkrehi 5253 10 in in IN cord-335975-m6lkrehi 5253 11 our -PRON- PRP$ cord-335975-m6lkrehi 5253 12 study study NN cord-335975-m6lkrehi 5253 13 , , , cord-335975-m6lkrehi 5253 14 glycemic glycemic JJ cord-335975-m6lkrehi 5253 15 balance balance NN cord-335975-m6lkrehi 5253 16 and and CC cord-335975-m6lkrehi 5253 17 rapid rapid JJ cord-335975-m6lkrehi 5253 18 airway airway NN cord-335975-m6lkrehi 5253 19 safety safety NN cord-335975-m6lkrehi 5253 20 by by IN cord-335975-m6lkrehi 5253 21 orotracheal orotracheal JJ cord-335975-m6lkrehi 5253 22 intubation intubation NN cord-335975-m6lkrehi 5253 23 in in IN cord-335975-m6lkrehi 5253 24 the the DT cord-335975-m6lkrehi 5253 25 case case NN cord-335975-m6lkrehi 5253 26 of of IN cord-335975-m6lkrehi 5253 27 initial initial JJ cord-335975-m6lkrehi 5253 28 GCS GCS NNP cord-335975-m6lkrehi 5253 29 < < XX cord-335975-m6lkrehi 5253 30 8 8 CD cord-335975-m6lkrehi 5253 31 represent represent VBP cord-335975-m6lkrehi 5253 32 the the DT cord-335975-m6lkrehi 5253 33 2 2 CD cord-335975-m6lkrehi 5253 34 relevant relevant JJ cord-335975-m6lkrehi 5253 35 prevention prevention NN cord-335975-m6lkrehi 5253 36 axes axis NNS cord-335975-m6lkrehi 5253 37 of of IN cord-335975-m6lkrehi 5253 38 VAP VAP NNP cord-335975-m6lkrehi 5253 39 in in IN cord-335975-m6lkrehi 5253 40 traumatic traumatic JJ cord-335975-m6lkrehi 5253 41 brain brain NN cord-335975-m6lkrehi 5253 42 injury injury NN cord-335975-m6lkrehi 5253 43 in in IN cord-335975-m6lkrehi 5253 44 older old JJR cord-335975-m6lkrehi 5253 45 adults adult NNS cord-335975-m6lkrehi 5253 46 . . . cord-335975-m6lkrehi 5254 1 Unfortunately unfortunately RB cord-335975-m6lkrehi 5254 2 , , , cord-335975-m6lkrehi 5254 3 it -PRON- PRP cord-335975-m6lkrehi 5254 4 is be VBZ cord-335975-m6lkrehi 5254 5 accompanied accompany VBN cord-335975-m6lkrehi 5254 6 by by IN cord-335975-m6lkrehi 5254 7 a a DT cord-335975-m6lkrehi 5254 8 significant significant JJ cord-335975-m6lkrehi 5254 9 increase increase NN cord-335975-m6lkrehi 5254 10 in in IN cord-335975-m6lkrehi 5254 11 bacterial bacterial JJ cord-335975-m6lkrehi 5254 12 resistance resistance NN cord-335975-m6lkrehi 5254 13 to to IN cord-335975-m6lkrehi 5254 14 antibiotics antibiotic NNS cord-335975-m6lkrehi 5254 15 , , , cord-335975-m6lkrehi 5254 16 leading lead VBG cord-335975-m6lkrehi 5254 17 to to IN cord-335975-m6lkrehi 5254 18 an an DT cord-335975-m6lkrehi 5254 19 increase increase NN cord-335975-m6lkrehi 5254 20 in in IN cord-335975-m6lkrehi 5254 21 morbidity morbidity NN cord-335975-m6lkrehi 5254 22 and and CC cord-335975-m6lkrehi 5254 23 mortality mortality NN cord-335975-m6lkrehi 5254 24 in in IN cord-335975-m6lkrehi 5254 25 intensive intensive JJ cord-335975-m6lkrehi 5254 26 care care NN cord-335975-m6lkrehi 5254 27 units unit NNS cord-335975-m6lkrehi 5254 28 . . . cord-335975-m6lkrehi 5255 1 Patients patient NNS cord-335975-m6lkrehi 5255 2 and and CC cord-335975-m6lkrehi 5255 3 methods method NNS cord-335975-m6lkrehi 5255 4 : : : cord-335975-m6lkrehi 5255 5 This this DT cord-335975-m6lkrehi 5255 6 is be VBZ cord-335975-m6lkrehi 5255 7 a a DT cord-335975-m6lkrehi 5255 8 retrospective retrospective JJ cord-335975-m6lkrehi 5255 9 study study NN cord-335975-m6lkrehi 5255 10 carried carry VBD cord-335975-m6lkrehi 5255 11 out out RP cord-335975-m6lkrehi 5255 12 in in IN cord-335975-m6lkrehi 5255 13 our -PRON- PRP$ cord-335975-m6lkrehi 5255 14 intensive intensive JJ cord-335975-m6lkrehi 5255 15 care care NN cord-335975-m6lkrehi 5255 16 unit unit NN cord-335975-m6lkrehi 5255 17 , , , cord-335975-m6lkrehi 5255 18 covering cover VBG cord-335975-m6lkrehi 5255 19 all all DT cord-335975-m6lkrehi 5255 20 patients patient NNS cord-335975-m6lkrehi 5255 21 hospitalized hospitalize VBN cord-335975-m6lkrehi 5255 22 between between IN cord-335975-m6lkrehi 5255 23 January January NNP cord-335975-m6lkrehi 5255 24 2010 2010 CD cord-335975-m6lkrehi 5255 25 and and CC cord-335975-m6lkrehi 5255 26 June June NNP cord-335975-m6lkrehi 5255 27 2014 2014 CD cord-335975-m6lkrehi 5255 28 and and CC cord-335975-m6lkrehi 5255 29 having have VBG cord-335975-m6lkrehi 5255 30 contracted contract VBN cord-335975-m6lkrehi 5255 31 a a DT cord-335975-m6lkrehi 5255 32 nosocomial nosocomial JJ cord-335975-m6lkrehi 5255 33 urinary urinary JJ cord-335975-m6lkrehi 5255 34 infection infection NN cord-335975-m6lkrehi 5255 35 . . . cord-335975-m6lkrehi 5256 1 Patients patient NNS cord-335975-m6lkrehi 5256 2 whose whose WP$ cord-335975-m6lkrehi 5256 3 hospital hospital NN cord-335975-m6lkrehi 5256 4 stay stay NN cord-335975-m6lkrehi 5256 5 was be VBD cord-335975-m6lkrehi 5256 6 less less JJR cord-335975-m6lkrehi 5256 7 than than IN cord-335975-m6lkrehi 5256 8 48 48 CD cord-335975-m6lkrehi 5256 9 h h NN cord-335975-m6lkrehi 5256 10 and and CC cord-335975-m6lkrehi 5256 11 those those DT cord-335975-m6lkrehi 5256 12 Fig Fig NNP cord-335975-m6lkrehi 5256 13 . . NNP cord-335975-m6lkrehi 5256 14 1 1 CD cord-335975-m6lkrehi 5256 15 Agreement agreement NN cord-335975-m6lkrehi 5256 16 between between IN cord-335975-m6lkrehi 5256 17 VAE VAE NNP cord-335975-m6lkrehi 5256 18 and and CC cord-335975-m6lkrehi 5256 19 LRTI LRTI NNP cord-335975-m6lkrehi 5256 20 diagnostic diagnostic JJ cord-335975-m6lkrehi 5256 21 with with IN cord-335975-m6lkrehi 5256 22 a a DT cord-335975-m6lkrehi 5256 23 nosocomial nosocomial JJ cord-335975-m6lkrehi 5256 24 urinary urinary JJ cord-335975-m6lkrehi 5256 25 tract tract NN cord-335975-m6lkrehi 5256 26 infection infection NN cord-335975-m6lkrehi 5256 27 acquired acquire VBN cord-335975-m6lkrehi 5256 28 in in IN cord-335975-m6lkrehi 5256 29 another another DT cord-335975-m6lkrehi 5256 30 service service NN cord-335975-m6lkrehi 5256 31 were be VBD cord-335975-m6lkrehi 5256 32 excluded exclude VBN cord-335975-m6lkrehi 5256 33 . . . cord-335975-m6lkrehi 5257 1 Results result NNS cord-335975-m6lkrehi 5257 2 : : : cord-335975-m6lkrehi 5258 1 The the DT cord-335975-m6lkrehi 5258 2 study study NN cord-335975-m6lkrehi 5258 3 of of IN cord-335975-m6lkrehi 5258 4 resistance resistance NN cord-335975-m6lkrehi 5258 5 of of IN cord-335975-m6lkrehi 5258 6 the the DT cord-335975-m6lkrehi 5258 7 germs germ NNS cord-335975-m6lkrehi 5258 8 responsible responsible JJ cord-335975-m6lkrehi 5258 9 for for IN cord-335975-m6lkrehi 5258 10 nosocomial nosocomial JJ cord-335975-m6lkrehi 5258 11 urinary urinary JJ cord-335975-m6lkrehi 5258 12 tract tract NN cord-335975-m6lkrehi 5258 13 infection infection NN cord-335975-m6lkrehi 5258 14 showed show VBD cord-335975-m6lkrehi 5258 15 that that IN cord-335975-m6lkrehi 5258 16 - - : cord-335975-m6lkrehi 5258 17 Escherichia escherichia NN cord-335975-m6lkrehi 5258 18 - - HYPH cord-335975-m6lkrehi 5258 19 coli coli NNS cord-335975-m6lkrehi 5258 20 was be VBD cord-335975-m6lkrehi 5258 21 resistant resistant JJ cord-335975-m6lkrehi 5258 22 to to IN cord-335975-m6lkrehi 5258 23 Third third JJ cord-335975-m6lkrehi 5258 24 generation generation NN cord-335975-m6lkrehi 5258 25 cephalosporins cephalosporin NNS cord-335975-m6lkrehi 5258 26 in in IN cord-335975-m6lkrehi 5258 27 21 21 CD cord-335975-m6lkrehi 5258 28 % % NN cord-335975-m6lkrehi 5258 29 of of IN cord-335975-m6lkrehi 5258 30 cases case NNS cord-335975-m6lkrehi 5258 31 , , , cord-335975-m6lkrehi 5258 32 at at IN cord-335975-m6lkrehi 5258 33 imipenem imipenem NNP cord-335975-m6lkrehi 5258 34 in in IN cord-335975-m6lkrehi 5258 35 8 8 CD cord-335975-m6lkrehi 5258 36 % % NN cord-335975-m6lkrehi 5258 37 of of IN cord-335975-m6lkrehi 5258 38 cases case NNS cord-335975-m6lkrehi 5258 39 , , , cord-335975-m6lkrehi 5258 40 and and CC cord-335975-m6lkrehi 5258 41 without without IN cord-335975-m6lkrehi 5258 42 resistance resistance NN cord-335975-m6lkrehi 5258 43 to to IN cord-335975-m6lkrehi 5258 44 ertapenem ertapenem NN cord-335975-m6lkrehi 5258 45 and and CC cord-335975-m6lkrehi 5258 46 amikacin amikacin NNS cord-335975-m6lkrehi 5258 47 . . . cord-335975-m6lkrehi 5259 1 Pseudomonas Pseudomonas NNP cord-335975-m6lkrehi 5259 2 was be VBD cord-335975-m6lkrehi 5259 3 resistant resistant JJ cord-335975-m6lkrehi 5259 4 to to IN cord-335975-m6lkrehi 5259 5 ceftazidime ceftazidime NN cord-335975-m6lkrehi 5259 6 in in IN cord-335975-m6lkrehi 5259 7 61 61 CD cord-335975-m6lkrehi 5259 8 % % NN cord-335975-m6lkrehi 5259 9 of of IN cord-335975-m6lkrehi 5259 10 cases case NNS cord-335975-m6lkrehi 5259 11 , , , cord-335975-m6lkrehi 5259 12 to to IN cord-335975-m6lkrehi 5259 13 imipenem imipenem NNP cord-335975-m6lkrehi 5259 14 in in IN cord-335975-m6lkrehi 5259 15 64 64 CD cord-335975-m6lkrehi 5259 16 % % NN cord-335975-m6lkrehi 5259 17 of of IN cord-335975-m6lkrehi 5259 18 cases case NNS cord-335975-m6lkrehi 5259 19 and and CC cord-335975-m6lkrehi 5259 20 to to IN cord-335975-m6lkrehi 5259 21 amikacin amikacin VB cord-335975-m6lkrehi 5259 22 in in IN cord-335975-m6lkrehi 5259 23 44 44 CD cord-335975-m6lkrehi 5259 24 % % NN cord-335975-m6lkrehi 5259 25 of of IN cord-335975-m6lkrehi 5259 26 cases case NNS cord-335975-m6lkrehi 5259 27 . . . cord-335975-m6lkrehi 5260 1 Acinetobacter Acinetobacter NNP cord-335975-m6lkrehi 5260 2 baumannii baumannii NNP cord-335975-m6lkrehi 5260 3 was be VBD cord-335975-m6lkrehi 5260 4 resistant resistant JJ cord-335975-m6lkrehi 5260 5 to to IN cord-335975-m6lkrehi 5260 6 imipenem imipenem NNP cord-335975-m6lkrehi 5260 7 in in IN cord-335975-m6lkrehi 5260 8 87 87 CD cord-335975-m6lkrehi 5260 9 % % NN cord-335975-m6lkrehi 5260 10 of of IN cord-335975-m6lkrehi 5260 11 cases case NNS cord-335975-m6lkrehi 5260 12 and and CC cord-335975-m6lkrehi 5260 13 to to IN cord-335975-m6lkrehi 5260 14 amikacin amikacin VB cord-335975-m6lkrehi 5260 15 in in IN cord-335975-m6lkrehi 5260 16 85 85 CD cord-335975-m6lkrehi 5260 17 % % NN cord-335975-m6lkrehi 5260 18 of of IN cord-335975-m6lkrehi 5260 19 cases case NNS cord-335975-m6lkrehi 5260 20 . . . cord-335975-m6lkrehi 5261 1 Enterococcus Enterococcus NNP cord-335975-m6lkrehi 5261 2 faecalis faecalis NNP cord-335975-m6lkrehi 5261 3 had have VBD cord-335975-m6lkrehi 5261 4 no no DT cord-335975-m6lkrehi 5261 5 resistance resistance NN cord-335975-m6lkrehi 5261 6 to to IN cord-335975-m6lkrehi 5261 7 vancomycin vancomycin NN cord-335975-m6lkrehi 5261 8 and and CC cord-335975-m6lkrehi 5261 9 ampicillin ampicillin NN cord-335975-m6lkrehi 5261 10 . . . cord-335975-m6lkrehi 5262 1 Staphylococcus Staphylococcus NNP cord-335975-m6lkrehi 5262 2 aureus aureus NN cord-335975-m6lkrehi 5262 3 was be VBD cord-335975-m6lkrehi 5262 4 resistant resistant JJ cord-335975-m6lkrehi 5262 5 to to IN cord-335975-m6lkrehi 5262 6 methicillin methicillin NN cord-335975-m6lkrehi 5262 7 in in IN cord-335975-m6lkrehi 5262 8 25 25 CD cord-335975-m6lkrehi 5262 9 % % NN cord-335975-m6lkrehi 5262 10 of of IN cord-335975-m6lkrehi 5262 11 cases case NNS cord-335975-m6lkrehi 5262 12 and and CC cord-335975-m6lkrehi 5262 13 without without IN cord-335975-m6lkrehi 5262 14 any any DT cord-335975-m6lkrehi 5262 15 resistance resistance NN cord-335975-m6lkrehi 5262 16 to to IN cord-335975-m6lkrehi 5262 17 vancomycin vancomycin NNP cord-335975-m6lkrehi 5262 18 . . . cord-335975-m6lkrehi 5263 1 Mortality mortality NN cord-335975-m6lkrehi 5263 2 directly directly RB cord-335975-m6lkrehi 5263 3 associated associate VBN cord-335975-m6lkrehi 5263 4 with with IN cord-335975-m6lkrehi 5263 5 nosocomial nosocomial JJ cord-335975-m6lkrehi 5263 6 urinary urinary JJ cord-335975-m6lkrehi 5263 7 tract tract NN cord-335975-m6lkrehi 5263 8 infection infection NN cord-335975-m6lkrehi 5263 9 was be VBD cord-335975-m6lkrehi 5263 10 11 11 CD cord-335975-m6lkrehi 5263 11 % % NN cord-335975-m6lkrehi 5263 12 . . . cord-335975-m6lkrehi 5264 1 The the DT cord-335975-m6lkrehi 5264 2 comparison comparison NN cord-335975-m6lkrehi 5264 3 with with IN cord-335975-m6lkrehi 5264 4 previous previous JJ cord-335975-m6lkrehi 5264 5 studies study NNS cord-335975-m6lkrehi 5264 6 has have VBZ cord-335975-m6lkrehi 5264 7 shown show VBN cord-335975-m6lkrehi 5264 8 a a DT cord-335975-m6lkrehi 5264 9 significant significant JJ cord-335975-m6lkrehi 5264 10 increase increase NN cord-335975-m6lkrehi 5264 11 in in IN cord-335975-m6lkrehi 5264 12 the the DT cord-335975-m6lkrehi 5264 13 bacterial bacterial JJ cord-335975-m6lkrehi 5264 14 resistance resistance NN cord-335975-m6lkrehi 5264 15 responsible responsible JJ cord-335975-m6lkrehi 5264 16 for for IN cord-335975-m6lkrehi 5264 17 nosocomial nosocomial JJ cord-335975-m6lkrehi 5264 18 urinary urinary JJ cord-335975-m6lkrehi 5264 19 tract tract NN cord-335975-m6lkrehi 5264 20 infection infection NN cord-335975-m6lkrehi 5264 21 , , , cord-335975-m6lkrehi 5264 22 which which WDT cord-335975-m6lkrehi 5264 23 is be VBZ cord-335975-m6lkrehi 5264 24 of of IN cord-335975-m6lkrehi 5264 25 interest interest NN cord-335975-m6lkrehi 5264 26 in in IN cord-335975-m6lkrehi 5264 27 monitoring monitor VBG cord-335975-m6lkrehi 5264 28 the the DT cord-335975-m6lkrehi 5264 29 ecology ecology NN cord-335975-m6lkrehi 5264 30 of of IN cord-335975-m6lkrehi 5264 31 intensive intensive JJ cord-335975-m6lkrehi 5264 32 care care NN cord-335975-m6lkrehi 5264 33 units unit NNS cord-335975-m6lkrehi 5264 34 and and CC cord-335975-m6lkrehi 5264 35 the the DT cord-335975-m6lkrehi 5264 36 resistance resistance NN cord-335975-m6lkrehi 5264 37 profile profile NN cord-335975-m6lkrehi 5264 38 as as RB cord-335975-m6lkrehi 5264 39 well well RB cord-335975-m6lkrehi 5264 40 as as IN cord-335975-m6lkrehi 5264 41 the the DT cord-335975-m6lkrehi 5264 42 improvement improvement NN cord-335975-m6lkrehi 5264 43 of of IN cord-335975-m6lkrehi 5264 44 the the DT cord-335975-m6lkrehi 5264 45 management management NN cord-335975-m6lkrehi 5264 46 of of IN cord-335975-m6lkrehi 5264 47 antibiotics antibiotic NNS cord-335975-m6lkrehi 5264 48 . . . cord-335975-m6lkrehi 5265 1 Introduction introduction NN cord-335975-m6lkrehi 5265 2 : : : cord-335975-m6lkrehi 5266 1 Nosocomial nosocomial JJ cord-335975-m6lkrehi 5266 2 enterococcus enterococcus NN cord-335975-m6lkrehi 5266 3 infections infection NNS cord-335975-m6lkrehi 5266 4 are be VBP cord-335975-m6lkrehi 5266 5 a a DT cord-335975-m6lkrehi 5266 6 constant constant JJ cord-335975-m6lkrehi 5266 7 concern concern NN cord-335975-m6lkrehi 5266 8 in in IN cord-335975-m6lkrehi 5266 9 intensive intensive JJ cord-335975-m6lkrehi 5266 10 care care NN cord-335975-m6lkrehi 5266 11 units unit NNS cord-335975-m6lkrehi 5266 12 due due JJ cord-335975-m6lkrehi 5266 13 to to IN cord-335975-m6lkrehi 5266 14 their -PRON- PRP$ cord-335975-m6lkrehi 5266 15 increasing increase VBG cord-335975-m6lkrehi 5266 16 frequency frequency NN cord-335975-m6lkrehi 5266 17 and and CC cord-335975-m6lkrehi 5266 18 the the DT cord-335975-m6lkrehi 5266 19 emergence emergence NN cord-335975-m6lkrehi 5266 20 of of IN cord-335975-m6lkrehi 5266 21 resistant resistant JJ cord-335975-m6lkrehi 5266 22 strains strain NNS cord-335975-m6lkrehi 5266 23 to to IN cord-335975-m6lkrehi 5266 24 vancomycin vancomycin NN cord-335975-m6lkrehi 5266 25 . . . cord-335975-m6lkrehi 5267 1 The the DT cord-335975-m6lkrehi 5267 2 aim aim NN cord-335975-m6lkrehi 5267 3 of of IN cord-335975-m6lkrehi 5267 4 our -PRON- PRP$ cord-335975-m6lkrehi 5267 5 study study NN cord-335975-m6lkrehi 5267 6 was be VBD cord-335975-m6lkrehi 5267 7 to to TO cord-335975-m6lkrehi 5267 8 compare compare VB cord-335975-m6lkrehi 5267 9 outcome outcome NN cord-335975-m6lkrehi 5267 10 findings finding NNS cord-335975-m6lkrehi 5267 11 of of IN cord-335975-m6lkrehi 5267 12 patients patient NNS cord-335975-m6lkrehi 5267 13 with with IN cord-335975-m6lkrehi 5267 14 nosocomial nosocomial JJ cord-335975-m6lkrehi 5267 15 enterococcus enterococcus NN cord-335975-m6lkrehi 5267 16 infections infection NNS cord-335975-m6lkrehi 5267 17 according accord VBG cord-335975-m6lkrehi 5267 18 to to IN cord-335975-m6lkrehi 5267 19 their -PRON- PRP$ cord-335975-m6lkrehi 5267 20 sensibility sensibility NN cord-335975-m6lkrehi 5267 21 to to IN cord-335975-m6lkrehi 5267 22 vancomycin vancomycin NN cord-335975-m6lkrehi 5267 23 , , , cord-335975-m6lkrehi 5267 24 and and CC cord-335975-m6lkrehi 5267 25 then then RB cord-335975-m6lkrehi 5267 26 to to TO cord-335975-m6lkrehi 5267 27 investigate investigate VB cord-335975-m6lkrehi 5267 28 predictive predictive JJ cord-335975-m6lkrehi 5267 29 factors factor NNS cord-335975-m6lkrehi 5267 30 of of IN cord-335975-m6lkrehi 5267 31 mortality mortality NN cord-335975-m6lkrehi 5267 32 . . . cord-335975-m6lkrehi 5268 1 Patients patient NNS cord-335975-m6lkrehi 5268 2 and and CC cord-335975-m6lkrehi 5268 3 methods method NNS cord-335975-m6lkrehi 5269 1 : : : cord-335975-m6lkrehi 5269 2 It -PRON- PRP cord-335975-m6lkrehi 5269 3 was be VBD cord-335975-m6lkrehi 5269 4 a a DT cord-335975-m6lkrehi 5269 5 retrospective retrospective JJ cord-335975-m6lkrehi 5269 6 descriptive descriptive JJ cord-335975-m6lkrehi 5269 7 study study NN cord-335975-m6lkrehi 5269 8 , , , cord-335975-m6lkrehi 5269 9 including include VBG cord-335975-m6lkrehi 5269 10 all all DT cord-335975-m6lkrehi 5269 11 hospitalized hospitalize VBN cord-335975-m6lkrehi 5269 12 patients patient NNS cord-335975-m6lkrehi 5269 13 in in IN cord-335975-m6lkrehi 5269 14 intensive intensive JJ cord-335975-m6lkrehi 5269 15 care care NN cord-335975-m6lkrehi 5269 16 , , , cord-335975-m6lkrehi 5269 17 between between IN cord-335975-m6lkrehi 5269 18 January January NNP cord-335975-m6lkrehi 5269 19 1st 1st NN cord-335975-m6lkrehi 5269 20 , , , cord-335975-m6lkrehi 5269 21 2013 2013 CD cord-335975-m6lkrehi 5269 22 and and CC cord-335975-m6lkrehi 5269 23 April April NNP cord-335975-m6lkrehi 5269 24 1st 1st NN cord-335975-m6lkrehi 5269 25 , , , cord-335975-m6lkrehi 5269 26 2017 2017 CD cord-335975-m6lkrehi 5269 27 , , , cord-335975-m6lkrehi 5269 28 with with IN cord-335975-m6lkrehi 5269 29 nosocomial nosocomial JJ cord-335975-m6lkrehi 5269 30 enterococcus enterococcus NN cord-335975-m6lkrehi 5269 31 infections infection NNS cord-335975-m6lkrehi 5269 32 . . . cord-335975-m6lkrehi 5270 1 We -PRON- PRP cord-335975-m6lkrehi 5270 2 recorded record VBD cord-335975-m6lkrehi 5270 3 demographic demographic JJ cord-335975-m6lkrehi 5270 4 and and CC cord-335975-m6lkrehi 5270 5 clinical clinical JJ cord-335975-m6lkrehi 5270 6 findings finding NNS cord-335975-m6lkrehi 5270 7 , , , cord-335975-m6lkrehi 5270 8 severity severity NN cord-335975-m6lkrehi 5270 9 scores score NNS cord-335975-m6lkrehi 5270 10 IGS IGS NNP cord-335975-m6lkrehi 5270 11 II II NNP cord-335975-m6lkrehi 5270 12 , , , cord-335975-m6lkrehi 5270 13 APACHE APACHE NNP cord-335975-m6lkrehi 5270 14 II II NNP cord-335975-m6lkrehi 5270 15 , , , cord-335975-m6lkrehi 5270 16 initial initial JJ cord-335975-m6lkrehi 5270 17 SOFA sofa NN cord-335975-m6lkrehi 5270 18 and and CC cord-335975-m6lkrehi 5270 19 SOFA sofa NN cord-335975-m6lkrehi 5270 20 at at IN cord-335975-m6lkrehi 5270 21 the the DT cord-335975-m6lkrehi 5270 22 time time NN cord-335975-m6lkrehi 5270 23 of of IN cord-335975-m6lkrehi 5270 24 infection infection NN cord-335975-m6lkrehi 5270 25 , , , cord-335975-m6lkrehi 5270 26 microbiological microbiological JJ cord-335975-m6lkrehi 5270 27 , , , cord-335975-m6lkrehi 5270 28 therapeutic therapeutic JJ cord-335975-m6lkrehi 5270 29 and and CC cord-335975-m6lkrehi 5270 30 outcome outcome NN cord-335975-m6lkrehi 5270 31 data datum NNS cord-335975-m6lkrehi 5270 32 . . . cord-335975-m6lkrehi 5271 1 Patients patient NNS cord-335975-m6lkrehi 5271 2 infected infect VBN cord-335975-m6lkrehi 5271 3 with with IN cord-335975-m6lkrehi 5271 4 vancomycin vancomycin NN cord-335975-m6lkrehi 5271 5 - - HYPH cord-335975-m6lkrehi 5271 6 susceptible susceptible JJ cord-335975-m6lkrehi 5271 7 enterococcus enterococcus NN cord-335975-m6lkrehi 5271 8 ( ( -LRB- cord-335975-m6lkrehi 5271 9 VSE VSE NNP cord-335975-m6lkrehi 5271 10 ) ) -RRB- cord-335975-m6lkrehi 5271 11 were be VBD cord-335975-m6lkrehi 5271 12 compared compare VBN cord-335975-m6lkrehi 5271 13 to to IN cord-335975-m6lkrehi 5271 14 those those DT cord-335975-m6lkrehi 5271 15 having have VBG cord-335975-m6lkrehi 5271 16 vancomycin vancomycin NN cord-335975-m6lkrehi 5271 17 - - HYPH cord-335975-m6lkrehi 5271 18 resistant resistant JJ cord-335975-m6lkrehi 5271 19 enterococcus enterococcus NN cord-335975-m6lkrehi 5271 20 ( ( -LRB- cord-335975-m6lkrehi 5271 21 VRE VRE NNP cord-335975-m6lkrehi 5271 22 ) ) -RRB- cord-335975-m6lkrehi 5272 1 + + CC cord-335975-m6lkrehi 5272 2 then then RB cord-335975-m6lkrehi 5272 3 we -PRON- PRP cord-335975-m6lkrehi 5272 4 searched search VBD cord-335975-m6lkrehi 5272 5 for for IN cord-335975-m6lkrehi 5272 6 independent independent JJ cord-335975-m6lkrehi 5272 7 risk risk NN cord-335975-m6lkrehi 5272 8 factors factor NNS cord-335975-m6lkrehi 5272 9 for for IN cord-335975-m6lkrehi 5272 10 VRE VRE NNP cord-335975-m6lkrehi 5272 11 . . . cord-335975-m6lkrehi 5273 1 Finally finally RB cord-335975-m6lkrehi 5273 2 , , , cord-335975-m6lkrehi 5273 3 a a DT cord-335975-m6lkrehi 5273 4 multivariate multivariate JJ cord-335975-m6lkrehi 5273 5 logistic logistic JJ cord-335975-m6lkrehi 5273 6 regression regression NN cord-335975-m6lkrehi 5273 7 was be VBD cord-335975-m6lkrehi 5273 8 conducted conduct VBN cord-335975-m6lkrehi 5273 9 to to TO cord-335975-m6lkrehi 5273 10 investigate investigate VB cord-335975-m6lkrehi 5273 11 independent independent JJ cord-335975-m6lkrehi 5273 12 predictive predictive JJ cord-335975-m6lkrehi 5273 13 mortality mortality NN cord-335975-m6lkrehi 5273 14 factors factor NNS cord-335975-m6lkrehi 5273 15 . . . cord-335975-m6lkrehi 5274 1 Results result NNS cord-335975-m6lkrehi 5274 2 : : : cord-335975-m6lkrehi 5275 1 During during IN cord-335975-m6lkrehi 5275 2 the the DT cord-335975-m6lkrehi 5275 3 study study NN cord-335975-m6lkrehi 5275 4 period period NN cord-335975-m6lkrehi 5275 5 ( ( -LRB- cord-335975-m6lkrehi 5275 6 4 4 CD cord-335975-m6lkrehi 5275 7 years year NNS cord-335975-m6lkrehi 5275 8 and and CC cord-335975-m6lkrehi 5275 9 3 3 CD cord-335975-m6lkrehi 5275 10 months month NNS cord-335975-m6lkrehi 5275 11 ) ) -RRB- cord-335975-m6lkrehi 5275 12 , , , cord-335975-m6lkrehi 5275 13 35 35 CD cord-335975-m6lkrehi 5275 14 patients patient NNS cord-335975-m6lkrehi 5275 15 presented present VBD cord-335975-m6lkrehi 5275 16 a a DT cord-335975-m6lkrehi 5275 17 nosocomial nosocomial JJ cord-335975-m6lkrehi 5275 18 enterococcus enterococcus NN cord-335975-m6lkrehi 5275 19 infection infection NN cord-335975-m6lkrehi 5275 20 with with IN cord-335975-m6lkrehi 5275 21 a a DT cord-335975-m6lkrehi 5275 22 median median JJ cord-335975-m6lkrehi 5275 23 age age NN cord-335975-m6lkrehi 5275 24 of of IN cord-335975-m6lkrehi 5275 25 63 63 CD cord-335975-m6lkrehi 5275 26 years year NNS cord-335975-m6lkrehi 5275 27 [ [ -LRB- cord-335975-m6lkrehi 5275 28 25 25 CD cord-335975-m6lkrehi 5275 29 - - SYM cord-335975-m6lkrehi 5275 30 87 87 CD cord-335975-m6lkrehi 5275 31 ] ] -RRB- cord-335975-m6lkrehi 5275 32 and and CC cord-335975-m6lkrehi 5275 33 a a DT cord-335975-m6lkrehi 5275 34 sex sex NN cord-335975-m6lkrehi 5275 35 - - HYPH cord-335975-m6lkrehi 5275 36 ratio ratio NN cord-335975-m6lkrehi 5275 37 of of IN cord-335975-m6lkrehi 5275 38 2.18 2.18 CD cord-335975-m6lkrehi 5275 39 . . . cord-335975-m6lkrehi 5276 1 At at IN cord-335975-m6lkrehi 5276 2 admission admission NN cord-335975-m6lkrehi 5276 3 , , , cord-335975-m6lkrehi 5276 4 31 31 CD cord-335975-m6lkrehi 5276 5 patients patient NNS cord-335975-m6lkrehi 5276 6 ( ( -LRB- cord-335975-m6lkrehi 5276 7 83.3 83.3 CD cord-335975-m6lkrehi 5276 8 % % NN cord-335975-m6lkrehi 5276 9 ) ) -RRB- cord-335975-m6lkrehi 5276 10 had have VBD cord-335975-m6lkrehi 5276 11 respiratory respiratory JJ cord-335975-m6lkrehi 5276 12 distress distress NN cord-335975-m6lkrehi 5276 13 . . . cord-335975-m6lkrehi 5277 1 The the DT cord-335975-m6lkrehi 5277 2 median median JJ cord-335975-m6lkrehi 5277 3 scores score NNS cord-335975-m6lkrehi 5277 4 of of IN cord-335975-m6lkrehi 5277 5 IGS IGS NNP cord-335975-m6lkrehi 5277 6 II II NNP cord-335975-m6lkrehi 5277 7 , , , cord-335975-m6lkrehi 5277 8 APACHE APACHE NNP cord-335975-m6lkrehi 5277 9 II II NNP cord-335975-m6lkrehi 5277 10 , , , cord-335975-m6lkrehi 5277 11 initial initial JJ cord-335975-m6lkrehi 5277 12 SOFA sofa NN cord-335975-m6lkrehi 5277 13 and and CC cord-335975-m6lkrehi 5277 14 SOFA sofa NN cord-335975-m6lkrehi 5277 15 at at IN cord-335975-m6lkrehi 5277 16 the the DT cord-335975-m6lkrehi 5277 17 time time NN cord-335975-m6lkrehi 5277 18 of of IN cord-335975-m6lkrehi 5277 19 infection infection NN cord-335975-m6lkrehi 5277 20 were be VBD cord-335975-m6lkrehi 5277 21 respectively respectively RB cord-335975-m6lkrehi 5277 22 45 45 CD cord-335975-m6lkrehi 5277 23 + + SYM cord-335975-m6lkrehi 5277 24 16 16 CD cord-335975-m6lkrehi 5277 25 + + SYM cord-335975-m6lkrehi 5277 26 6 6 CD cord-335975-m6lkrehi 5277 27 and and CC cord-335975-m6lkrehi 5277 28 6 6 CD cord-335975-m6lkrehi 5277 29 . . . cord-335975-m6lkrehi 5278 1 The the DT cord-335975-m6lkrehi 5278 2 infection infection NN cord-335975-m6lkrehi 5278 3 sites site NNS cord-335975-m6lkrehi 5278 4 were be VBD cord-335975-m6lkrehi 5278 5 - - HYPH cord-335975-m6lkrehi 5278 6 urinary urinary JJ cord-335975-m6lkrehi 5278 7 infection infection NN cord-335975-m6lkrehi 5279 1 ( ( -LRB- cord-335975-m6lkrehi 5279 2 n n NN cord-335975-m6lkrehi 5279 3 = = SYM cord-335975-m6lkrehi 5279 4 17 17 CD cord-335975-m6lkrehi 5279 5 , , , cord-335975-m6lkrehi 5279 6 48.6 48.6 CD cord-335975-m6lkrehi 5279 7 % % NN cord-335975-m6lkrehi 5279 8 ) ) -RRB- cord-335975-m6lkrehi 5279 9 , , , cord-335975-m6lkrehi 5279 10 bacteremia bacteremia NN cord-335975-m6lkrehi 5279 11 ( ( -LRB- cord-335975-m6lkrehi 5279 12 n n NN cord-335975-m6lkrehi 5279 13 = = SYM cord-335975-m6lkrehi 5279 14 15 15 CD cord-335975-m6lkrehi 5279 15 , , , cord-335975-m6lkrehi 5279 16 42.9 42.9 CD cord-335975-m6lkrehi 5279 17 % % NN cord-335975-m6lkrehi 5279 18 ) ) -RRB- cord-335975-m6lkrehi 5279 19 and and CC cord-335975-m6lkrehi 5279 20 central central JJ cord-335975-m6lkrehi 5279 21 line line NN cord-335975-m6lkrehi 5279 22 associated associate VBN cord-335975-m6lkrehi 5279 23 infection infection NN cord-335975-m6lkrehi 5279 24 ( ( -LRB- cord-335975-m6lkrehi 5279 25 n n NN cord-335975-m6lkrehi 5279 26 = = SYM cord-335975-m6lkrehi 5279 27 3 3 CD cord-335975-m6lkrehi 5279 28 , , , cord-335975-m6lkrehi 5279 29 8.5%).16 8.5%).16 CD cord-335975-m6lkrehi 5279 30 patients patient NNS cord-335975-m6lkrehi 5279 31 had have VBD cord-335975-m6lkrehi 5279 32 a a DT cord-335975-m6lkrehi 5279 33 VRE VRE NNP cord-335975-m6lkrehi 5279 34 nosocomial nosocomial JJ cord-335975-m6lkrehi 5279 35 infections infection NNS cord-335975-m6lkrehi 5279 36 and and CC cord-335975-m6lkrehi 5279 37 19 19 CD cord-335975-m6lkrehi 5279 38 VSE vse NN cord-335975-m6lkrehi 5279 39 . . . cord-335975-m6lkrehi 5280 1 A a DT cord-335975-m6lkrehi 5280 2 septic septic JJ cord-335975-m6lkrehi 5280 3 shock shock NN cord-335975-m6lkrehi 5280 4 complicated complicate VBD cord-335975-m6lkrehi 5280 5 enterococcus enterococcus NN cord-335975-m6lkrehi 5280 6 infection infection NN cord-335975-m6lkrehi 5280 7 in in IN cord-335975-m6lkrehi 5280 8 13 13 CD cord-335975-m6lkrehi 5280 9 cases case NNS cord-335975-m6lkrehi 5280 10 including include VBG cord-335975-m6lkrehi 5280 11 7 7 CD cord-335975-m6lkrehi 5280 12 cases case NNS cord-335975-m6lkrehi 5280 13 of of IN cord-335975-m6lkrehi 5280 14 VRE VRE NNP cord-335975-m6lkrehi 5280 15 and and CC cord-335975-m6lkrehi 5280 16 6 6 CD cord-335975-m6lkrehi 5280 17 cases case NNS cord-335975-m6lkrehi 5280 18 of of IN cord-335975-m6lkrehi 5280 19 VSE VSE NNP cord-335975-m6lkrehi 5280 20 ( ( -LRB- cord-335975-m6lkrehi 5280 21 p p NN cord-335975-m6lkrehi 5280 22 = = SYM cord-335975-m6lkrehi 5280 23 0.458 0.458 CD cord-335975-m6lkrehi 5280 24 ) ) -RRB- cord-335975-m6lkrehi 5280 25 . . . cord-335975-m6lkrehi 5281 1 VRE VRE NNP cord-335975-m6lkrehi 5281 2 nosocomial nosocomial JJ cord-335975-m6lkrehi 5281 3 infections infection NNS cord-335975-m6lkrehi 5281 4 were be VBD cord-335975-m6lkrehi 5281 5 significantly significantly RB cord-335975-m6lkrehi 5281 6 related relate VBN cord-335975-m6lkrehi 5281 7 to to IN cord-335975-m6lkrehi 5281 8 arterial arterial JJ cord-335975-m6lkrehi 5281 9 ( ( -LRB- cord-335975-m6lkrehi 5281 10 p p NN cord-335975-m6lkrehi 5281 11 = = SYM cord-335975-m6lkrehi 5281 12 0.006 0.006 CD cord-335975-m6lkrehi 5281 13 ) ) -RRB- cord-335975-m6lkrehi 5281 14 and and CC cord-335975-m6lkrehi 5281 15 venous venous JJ cord-335975-m6lkrehi 5281 16 ( ( -LRB- cord-335975-m6lkrehi 5281 17 p p NN cord-335975-m6lkrehi 5281 18 = = SYM cord-335975-m6lkrehi 5281 19 0.009 0.009 CD cord-335975-m6lkrehi 5281 20 ) ) -RRB- cord-335975-m6lkrehi 5282 1 femoral femoral JJ cord-335975-m6lkrehi 5282 2 catheterization catheterization NN cord-335975-m6lkrehi 5282 3 , , , cord-335975-m6lkrehi 5282 4 to to IN cord-335975-m6lkrehi 5282 5 a a DT cord-335975-m6lkrehi 5282 6 duration duration NN cord-335975-m6lkrehi 5282 7 of of IN cord-335975-m6lkrehi 5282 8 venous venous JJ cord-335975-m6lkrehi 5282 9 femoral femoral JJ cord-335975-m6lkrehi 5282 10 catheterization catheterization NN cord-335975-m6lkrehi 5282 11 > > XX cord-335975-m6lkrehi 5282 12 3 3 CD cord-335975-m6lkrehi 5282 13 days day NNS cord-335975-m6lkrehi 5283 1 ( ( -LRB- cord-335975-m6lkrehi 5283 2 p p NN cord-335975-m6lkrehi 5283 3 = = SYM cord-335975-m6lkrehi 5283 4 0.035 0.035 CD cord-335975-m6lkrehi 5283 5 ) ) -RRB- cord-335975-m6lkrehi 5283 6 and and CC cord-335975-m6lkrehi 5283 7 to to IN cord-335975-m6lkrehi 5283 8 E. E. NNP cord-335975-m6lkrehi 5283 9 faecium faecium NN cord-335975-m6lkrehi 5283 10 species specie NNS cord-335975-m6lkrehi 5283 11 ( ( -LRB- cord-335975-m6lkrehi 5283 12 p p NN cord-335975-m6lkrehi 5283 13 < < XX cord-335975-m6lkrehi 5283 14 10 10 CD cord-335975-m6lkrehi 5283 15 - - SYM cord-335975-m6lkrehi 5283 16 3 3 CD cord-335975-m6lkrehi 5283 17 ) ) -RRB- cord-335975-m6lkrehi 5283 18 . . . cord-335975-m6lkrehi 5284 1 No no DT cord-335975-m6lkrehi 5284 2 independent independent JJ cord-335975-m6lkrehi 5284 3 risk risk NN cord-335975-m6lkrehi 5284 4 factor factor NN cord-335975-m6lkrehi 5284 5 of of IN cord-335975-m6lkrehi 5284 6 VRE VRE NNP cord-335975-m6lkrehi 5284 7 was be VBD cord-335975-m6lkrehi 5284 8 found find VBN cord-335975-m6lkrehi 5284 9 . . . cord-335975-m6lkrehi 5285 1 The the DT cord-335975-m6lkrehi 5285 2 median median JJ cord-335975-m6lkrehi 5285 3 duration duration NN cord-335975-m6lkrehi 5285 4 of of IN cord-335975-m6lkrehi 5285 5 hospitalization hospitalization NN cord-335975-m6lkrehi 5285 6 was be VBD cord-335975-m6lkrehi 5285 7 34 34 CD cord-335975-m6lkrehi 5285 8 days day NNS cord-335975-m6lkrehi 5285 9 and and CC cord-335975-m6lkrehi 5285 10 the the DT cord-335975-m6lkrehi 5285 11 overall overall JJ cord-335975-m6lkrehi 5285 12 mortality mortality NN cord-335975-m6lkrehi 5285 13 rate rate NN cord-335975-m6lkrehi 5285 14 was be VBD cord-335975-m6lkrehi 5285 15 68.6 68.6 CD cord-335975-m6lkrehi 5285 16 % % NN cord-335975-m6lkrehi 5285 17 . . . cord-335975-m6lkrehi 5286 1 Multivariate multivariate JJ cord-335975-m6lkrehi 5286 2 analysis analysis NN cord-335975-m6lkrehi 5286 3 identified identify VBD cord-335975-m6lkrehi 5286 4 2 2 CD cord-335975-m6lkrehi 5286 5 independent independent JJ cord-335975-m6lkrehi 5286 6 predictive predictive JJ cord-335975-m6lkrehi 5286 7 factors factor NNS cord-335975-m6lkrehi 5286 8 of of IN cord-335975-m6lkrehi 5286 9 attributable attributable JJ cord-335975-m6lkrehi 5286 10 mortality mortality NN cord-335975-m6lkrehi 5286 11 - - HYPH cord-335975-m6lkrehi 5286 12 patients patient NNS cord-335975-m6lkrehi 5286 13 in in IN cord-335975-m6lkrehi 5286 14 coma coma NN cord-335975-m6lkrehi 5286 15 ( ( -LRB- cord-335975-m6lkrehi 5286 16 OR or CC cord-335975-m6lkrehi 5286 17 30.44 30.44 CD cord-335975-m6lkrehi 5286 18 + + SYM cord-335975-m6lkrehi 5286 19 IC IC NNP cord-335975-m6lkrehi 5286 20 95 95 CD cord-335975-m6lkrehi 5286 21 % % NN cord-335975-m6lkrehi 5286 22 = = SYM cord-335975-m6lkrehi 5286 23 1.99 1.99 CD cord-335975-m6lkrehi 5286 24 - - SYM cord-335975-m6lkrehi 5286 25 465.39 465.39 CD cord-335975-m6lkrehi 5286 26 + + SYM cord-335975-m6lkrehi 5286 27 p p NN cord-335975-m6lkrehi 5286 28 = = SYM cord-335975-m6lkrehi 5286 29 0.014 0.014 CD cord-335975-m6lkrehi 5286 30 ) ) -RRB- cord-335975-m6lkrehi 5286 31 and and CC cord-335975-m6lkrehi 5286 32 the the DT cord-335975-m6lkrehi 5286 33 occurrence occurrence NN cord-335975-m6lkrehi 5286 34 of of IN cord-335975-m6lkrehi 5286 35 septic septic JJ cord-335975-m6lkrehi 5286 36 shock shock NN cord-335975-m6lkrehi 5286 37 ( ( -LRB- cord-335975-m6lkrehi 5286 38 OR OR NNP cord-335975-m6lkrehi 5286 39 14.4 14.4 CD cord-335975-m6lkrehi 5286 40 + + SYM cord-335975-m6lkrehi 5286 41 IC IC NNP cord-335975-m6lkrehi 5286 42 95 95 CD cord-335975-m6lkrehi 5286 43 % % NN cord-335975-m6lkrehi 5286 44 = = SYM cord-335975-m6lkrehi 5286 45 1.45 1.45 CD cord-335975-m6lkrehi 5286 46 - - SYM cord-335975-m6lkrehi 5286 47 137.72 137.72 CD cord-335975-m6lkrehi 5286 48 + + SYM cord-335975-m6lkrehi 5286 49 p p NN cord-335975-m6lkrehi 5286 50 = = SYM cord-335975-m6lkrehi 5286 51 0.023 0.023 CD cord-335975-m6lkrehi 5286 52 ) ) -RRB- cord-335975-m6lkrehi 5286 53 . . . cord-335975-m6lkrehi 5287 1 Conclusion conclusion NN cord-335975-m6lkrehi 5287 2 : : : cord-335975-m6lkrehi 5288 1 Attributable attributable JJ cord-335975-m6lkrehi 5288 2 mortality mortality NN cord-335975-m6lkrehi 5288 3 to to IN cord-335975-m6lkrehi 5288 4 nosocomial nosocomial JJ cord-335975-m6lkrehi 5288 5 enterococcus enterococcus NN cord-335975-m6lkrehi 5288 6 infections infection NNS cord-335975-m6lkrehi 5288 7 was be VBD cord-335975-m6lkrehi 5288 8 high high JJ cord-335975-m6lkrehi 5288 9 and and CC cord-335975-m6lkrehi 5288 10 independent independent JJ cord-335975-m6lkrehi 5288 11 of of IN cord-335975-m6lkrehi 5288 12 the the DT cord-335975-m6lkrehi 5288 13 susceptibility susceptibility NN cord-335975-m6lkrehi 5288 14 of of IN cord-335975-m6lkrehi 5288 15 the the DT cord-335975-m6lkrehi 5288 16 strain strain NN cord-335975-m6lkrehi 5288 17 to to IN cord-335975-m6lkrehi 5288 18 vancomycin vancomycin NNP cord-335975-m6lkrehi 5288 19 . . . cord-335975-m6lkrehi 5289 1 Mortality mortality NN cord-335975-m6lkrehi 5289 2 was be VBD cord-335975-m6lkrehi 5289 3 independently independently RB cord-335975-m6lkrehi 5289 4 associated associate VBN cord-335975-m6lkrehi 5289 5 to to IN cord-335975-m6lkrehi 5289 6 septic septic JJ cord-335975-m6lkrehi 5289 7 schock schock NNP cord-335975-m6lkrehi 5289 8 occurrence occurrence NN cord-335975-m6lkrehi 5289 9 and and CC cord-335975-m6lkrehi 5289 10 neurologic neurologic JJ cord-335975-m6lkrehi 5289 11 dysfonction dysfonction NN cord-335975-m6lkrehi 5289 12 . . . cord-335975-m6lkrehi 5290 1 Introduction introduction NN cord-335975-m6lkrehi 5290 2 : : : cord-335975-m6lkrehi 5291 1 Ventilator Ventilator NNP cord-335975-m6lkrehi 5291 2 - - HYPH cord-335975-m6lkrehi 5291 3 Associated Associated NNP cord-335975-m6lkrehi 5291 4 Pneumonia Pneumonia NNP cord-335975-m6lkrehi 5291 5 ( ( -LRB- cord-335975-m6lkrehi 5291 6 VAP VAP NNP cord-335975-m6lkrehi 5291 7 ) ) -RRB- cord-335975-m6lkrehi 5291 8 is be VBZ cord-335975-m6lkrehi 5291 9 defined define VBN cord-335975-m6lkrehi 5291 10 by by IN cord-335975-m6lkrehi 5291 11 a a DT cord-335975-m6lkrehi 5291 12 lung lung NN cord-335975-m6lkrehi 5291 13 infection infection NN cord-335975-m6lkrehi 5291 14 contracted contract VBD cord-335975-m6lkrehi 5291 15 48 48 CD cord-335975-m6lkrehi 5291 16 h h NN cord-335975-m6lkrehi 5291 17 after after IN cord-335975-m6lkrehi 5291 18 the the DT cord-335975-m6lkrehi 5291 19 putting putting NN cord-335975-m6lkrehi 5291 20 under under IN cord-335975-m6lkrehi 5291 21 mechanically mechanically RB cord-335975-m6lkrehi 5291 22 assisted assist VBN cord-335975-m6lkrehi 5291 23 breathing breathing NN cord-335975-m6lkrehi 5291 24 . . . cord-335975-m6lkrehi 5292 1 Risk risk NN cord-335975-m6lkrehi 5292 2 factors factor NNS cord-335975-m6lkrehi 5292 3 predisposing predispose VBG cord-335975-m6lkrehi 5292 4 to to IN cord-335975-m6lkrehi 5292 5 the the DT cord-335975-m6lkrehi 5292 6 development development NN cord-335975-m6lkrehi 5292 7 of of IN cord-335975-m6lkrehi 5292 8 VAP VAP NNP cord-335975-m6lkrehi 5292 9 among among IN cord-335975-m6lkrehi 5292 10 mechanically mechanically RB cord-335975-m6lkrehi 5292 11 ventilated ventilate VBN cord-335975-m6lkrehi 5292 12 patients patient NNS cord-335975-m6lkrehi 5292 13 are be VBP cord-335975-m6lkrehi 5292 14 many many JJ cord-335975-m6lkrehi 5292 15 . . . cord-335975-m6lkrehi 5293 1 Some some DT cord-335975-m6lkrehi 5293 2 are be VBP cord-335975-m6lkrehi 5293 3 related relate VBN cord-335975-m6lkrehi 5293 4 to to IN cord-335975-m6lkrehi 5293 5 the the DT cord-335975-m6lkrehi 5293 6 patient patient NN cord-335975-m6lkrehi 5293 7 as as IN cord-335975-m6lkrehi 5293 8 age age NN cord-335975-m6lkrehi 5293 9 , , , cord-335975-m6lkrehi 5293 10 history history NN cord-335975-m6lkrehi 5293 11 of of IN cord-335975-m6lkrehi 5293 12 COPD COPD NNP cord-335975-m6lkrehi 5293 13 , , , cord-335975-m6lkrehi 5293 14 presence presence NN cord-335975-m6lkrehi 5293 15 of of IN cord-335975-m6lkrehi 5293 16 an an DT cord-335975-m6lkrehi 5293 17 altered alter VBN cord-335975-m6lkrehi 5293 18 state state NN cord-335975-m6lkrehi 5293 19 of of IN cord-335975-m6lkrehi 5293 20 consciousness consciousness NN cord-335975-m6lkrehi 5293 21 + + CC cord-335975-m6lkrehi 5293 22 others other NNS cord-335975-m6lkrehi 5293 23 are be VBP cord-335975-m6lkrehi 5293 24 related relate VBN cord-335975-m6lkrehi 5293 25 to to TO cord-335975-m6lkrehi 5293 26 care care VB cord-335975-m6lkrehi 5293 27 providing provide VBG cord-335975-m6lkrehi 5293 28 . . . cord-335975-m6lkrehi 5294 1 Patients patient NNS cord-335975-m6lkrehi 5294 2 and and CC cord-335975-m6lkrehi 5294 3 methods method NNS cord-335975-m6lkrehi 5294 4 : : : cord-335975-m6lkrehi 5295 1 A a DT cord-335975-m6lkrehi 5295 2 prospective prospective JJ cord-335975-m6lkrehi 5295 3 nested nest VBN cord-335975-m6lkrehi 5295 4 case case NN cord-335975-m6lkrehi 5295 5 control control NN cord-335975-m6lkrehi 5295 6 study study NN cord-335975-m6lkrehi 5295 7 was be VBD cord-335975-m6lkrehi 5295 8 conducted conduct VBN cord-335975-m6lkrehi 5295 9 from from IN cord-335975-m6lkrehi 5295 10 Marsh Marsh NNP cord-335975-m6lkrehi 5295 11 2014 2014 CD cord-335975-m6lkrehi 5295 12 through through IN cord-335975-m6lkrehi 5295 13 April April NNP cord-335975-m6lkrehi 5295 14 2015 2015 CD cord-335975-m6lkrehi 5295 15 . . . cord-335975-m6lkrehi 5296 1 All all DT cord-335975-m6lkrehi 5296 2 ICU ICU NNP cord-335975-m6lkrehi 5296 3 patients patient NNS cord-335975-m6lkrehi 5296 4 mechanically mechanically RB cord-335975-m6lkrehi 5296 5 ventilated ventilate VBD cord-335975-m6lkrehi 5296 6 for for IN cord-335975-m6lkrehi 5296 7 more more JJR cord-335975-m6lkrehi 5296 8 than than IN cord-335975-m6lkrehi 5296 9 48 48 CD cord-335975-m6lkrehi 5296 10 h h NN cord-335975-m6lkrehi 5296 11 with with IN cord-335975-m6lkrehi 5296 12 endotracheal endotracheal JJ cord-335975-m6lkrehi 5296 13 intubation intubation NN cord-335975-m6lkrehi 5296 14 or or CC cord-335975-m6lkrehi 5296 15 tracheostomy tracheostomy NN cord-335975-m6lkrehi 5296 16 were be VBD cord-335975-m6lkrehi 5296 17 included include VBN cord-335975-m6lkrehi 5296 18 . . . cord-335975-m6lkrehi 5297 1 Cases case NNS cord-335975-m6lkrehi 5297 2 of of IN cord-335975-m6lkrehi 5297 3 community community NN cord-335975-m6lkrehi 5297 4 - - HYPH cord-335975-m6lkrehi 5297 5 acquired acquire VBN cord-335975-m6lkrehi 5297 6 pneumonia pneumonia NN cord-335975-m6lkrehi 5297 7 , , , cord-335975-m6lkrehi 5297 8 non non JJ cord-335975-m6lkrehi 5297 9 - - JJ cord-335975-m6lkrehi 5297 10 mechanical mechanical JJ cord-335975-m6lkrehi 5297 11 ventilated ventilate VBN cord-335975-m6lkrehi 5297 12 hospital hospital NN cord-335975-m6lkrehi 5297 13 - - HYPH cord-335975-m6lkrehi 5297 14 acquired acquire VBN cord-335975-m6lkrehi 5297 15 pneumonia pneumonia NN cord-335975-m6lkrehi 5297 16 , , , cord-335975-m6lkrehi 5297 17 end end NN cord-335975-m6lkrehi 5297 18 - - HYPH cord-335975-m6lkrehi 5297 19 life life NN cord-335975-m6lkrehi 5297 20 patients patient NNS cord-335975-m6lkrehi 5297 21 and and CC cord-335975-m6lkrehi 5297 22 those those DT cord-335975-m6lkrehi 5297 23 aged aged JJ cord-335975-m6lkrehi 5297 24 less less JJR cord-335975-m6lkrehi 5297 25 than than IN cord-335975-m6lkrehi 5297 26 18 18 CD cord-335975-m6lkrehi 5297 27 years year NNS cord-335975-m6lkrehi 5297 28 were be VBD cord-335975-m6lkrehi 5297 29 excluded exclude VBN cord-335975-m6lkrehi 5297 30 . . . cord-335975-m6lkrehi 5298 1 The the DT cord-335975-m6lkrehi 5298 2 included include VBN cord-335975-m6lkrehi 5298 3 patients patient NNS cord-335975-m6lkrehi 5298 4 with with IN cord-335975-m6lkrehi 5298 5 VAP VAP NNP cord-335975-m6lkrehi 5298 6 and and CC cord-335975-m6lkrehi 5298 7 those those DT cord-335975-m6lkrehi 5298 8 without without IN cord-335975-m6lkrehi 5298 9 VAP VAP NNP cord-335975-m6lkrehi 5298 10 were be VBD cord-335975-m6lkrehi 5298 11 matched match VBN cord-335975-m6lkrehi 5298 12 based base VBN cord-335975-m6lkrehi 5298 13 on on IN cord-335975-m6lkrehi 5298 14 the the DT cord-335975-m6lkrehi 5298 15 age age NN cord-335975-m6lkrehi 5298 16 , , , cord-335975-m6lkrehi 5298 17 the the DT cord-335975-m6lkrehi 5298 18 severity severity NN cord-335975-m6lkrehi 5298 19 score score NN cord-335975-m6lkrehi 5298 20 and and CC cord-335975-m6lkrehi 5298 21 the the DT cord-335975-m6lkrehi 5298 22 comorbidities comorbiditie NNS cord-335975-m6lkrehi 5298 23 . . . cord-335975-m6lkrehi 5299 1 For for IN cord-335975-m6lkrehi 5299 2 all all DT cord-335975-m6lkrehi 5299 3 patients patient NNS cord-335975-m6lkrehi 5299 4 included include VBN cord-335975-m6lkrehi 5299 5 , , , cord-335975-m6lkrehi 5299 6 preventive preventive JJ cord-335975-m6lkrehi 5299 7 measures measure NNS cord-335975-m6lkrehi 5299 8 as as IN cord-335975-m6lkrehi 5299 9 assessed assess VBN cord-335975-m6lkrehi 5299 10 by by IN cord-335975-m6lkrehi 5299 11 the the DT cord-335975-m6lkrehi 5299 12 recent recent JJ cord-335975-m6lkrehi 5299 13 guidelines guideline NNS cord-335975-m6lkrehi 5299 14 for for IN cord-335975-m6lkrehi 5299 15 preventing prevent VBG cord-335975-m6lkrehi 5299 16 VAP VAP NNP cord-335975-m6lkrehi 5299 17 were be VBD cord-335975-m6lkrehi 5299 18 applied apply VBN cord-335975-m6lkrehi 5299 19 after after IN cord-335975-m6lkrehi 5299 20 an an DT cord-335975-m6lkrehi 5299 21 education education NN cord-335975-m6lkrehi 5299 22 period period NN cord-335975-m6lkrehi 5299 23 of of IN cord-335975-m6lkrehi 5299 24 all all DT cord-335975-m6lkrehi 5299 25 medical medical JJ cord-335975-m6lkrehi 5299 26 and and CC cord-335975-m6lkrehi 5299 27 paramedical paramedical JJ cord-335975-m6lkrehi 5299 28 staff staff NN cord-335975-m6lkrehi 5299 29 of of IN cord-335975-m6lkrehi 5299 30 the the DT cord-335975-m6lkrehi 5299 31 ICU ICU NNP cord-335975-m6lkrehi 5299 32 . . . cord-335975-m6lkrehi 5300 1 The the DT cord-335975-m6lkrehi 5300 2 collected collect VBN cord-335975-m6lkrehi 5300 3 data datum NNS cord-335975-m6lkrehi 5300 4 are be VBP cord-335975-m6lkrehi 5300 5 - - : cord-335975-m6lkrehi 5300 6 age age NN cord-335975-m6lkrehi 5300 7 , , , cord-335975-m6lkrehi 5300 8 comorbidities comorbiditie NNS cord-335975-m6lkrehi 5300 9 , , , cord-335975-m6lkrehi 5300 10 admission admission NN cord-335975-m6lkrehi 5300 11 severity severity NN cord-335975-m6lkrehi 5300 12 scores score NNS cord-335975-m6lkrehi 5300 13 , , , cord-335975-m6lkrehi 5300 14 time time NN cord-335975-m6lkrehi 5300 15 to to IN cord-335975-m6lkrehi 5300 16 onset onset NN cord-335975-m6lkrehi 5300 17 of of IN cord-335975-m6lkrehi 5300 18 VAP VAP NNP cord-335975-m6lkrehi 5300 19 , , , cord-335975-m6lkrehi 5300 20 prior prior JJ cord-335975-m6lkrehi 5300 21 antibiotic antibiotic JJ cord-335975-m6lkrehi 5300 22 therapy therapy NN cord-335975-m6lkrehi 5300 23 at at IN cord-335975-m6lkrehi 5300 24 the the DT cord-335975-m6lkrehi 5300 25 onset onset NN cord-335975-m6lkrehi 5300 26 of of IN cord-335975-m6lkrehi 5300 27 VAP VAP NNP cord-335975-m6lkrehi 5300 28 , , , cord-335975-m6lkrehi 5300 29 need need VB cord-335975-m6lkrehi 5300 30 for for IN cord-335975-m6lkrehi 5300 31 tracheostomy tracheostomy NN cord-335975-m6lkrehi 5300 32 , , , cord-335975-m6lkrehi 5300 33 duration duration NN cord-335975-m6lkrehi 5300 34 of of IN cord-335975-m6lkrehi 5300 35 mechanical mechanical JJ cord-335975-m6lkrehi 5300 36 ventilation ventilation NN cord-335975-m6lkrehi 5300 37 , , , cord-335975-m6lkrehi 5300 38 length length NN cord-335975-m6lkrehi 5300 39 of of IN cord-335975-m6lkrehi 5300 40 stay stay NN cord-335975-m6lkrehi 5300 41 in in IN cord-335975-m6lkrehi 5300 42 ICU ICU NNP cord-335975-m6lkrehi 5300 43 and and CC cord-335975-m6lkrehi 5300 44 become become VBN cord-335975-m6lkrehi 5300 45 . . . cord-335975-m6lkrehi 5301 1 Results result NNS cord-335975-m6lkrehi 5301 2 : : : cord-335975-m6lkrehi 5302 1 During during IN cord-335975-m6lkrehi 5302 2 the the DT cord-335975-m6lkrehi 5302 3 study study NN cord-335975-m6lkrehi 5302 4 period period NN cord-335975-m6lkrehi 5302 5 , , , cord-335975-m6lkrehi 5302 6 71 71 CD cord-335975-m6lkrehi 5302 7 patients patient NNS cord-335975-m6lkrehi 5302 8 were be VBD cord-335975-m6lkrehi 5302 9 mechanically mechanically RB cord-335975-m6lkrehi 5302 10 ventilated ventilate VBN cord-335975-m6lkrehi 5302 11 . . . cord-335975-m6lkrehi 5303 1 VAP VAP NNP cord-335975-m6lkrehi 5303 2 was be VBD cord-335975-m6lkrehi 5303 3 observed observe VBN cord-335975-m6lkrehi 5303 4 in in IN cord-335975-m6lkrehi 5303 5 42 42 CD cord-335975-m6lkrehi 5303 6 % % NN cord-335975-m6lkrehi 5303 7 of of IN cord-335975-m6lkrehi 5303 8 cases case NNS cord-335975-m6lkrehi 5303 9 . . . cord-335975-m6lkrehi 5304 1 VAP VAP NNP cord-335975-m6lkrehi 5304 2 was be VBD cord-335975-m6lkrehi 5304 3 observed observe VBN cord-335975-m6lkrehi 5304 4 in in IN cord-335975-m6lkrehi 5304 5 27 27 CD cord-335975-m6lkrehi 5304 6 cases case NNS cord-335975-m6lkrehi 5304 7 with with IN cord-335975-m6lkrehi 5304 8 an an DT cord-335975-m6lkrehi 5304 9 incidence incidence NN cord-335975-m6lkrehi 5304 10 of of IN cord-335975-m6lkrehi 5304 11 38 38 CD cord-335975-m6lkrehi 5304 12 % % NN cord-335975-m6lkrehi 5304 13 and and CC cord-335975-m6lkrehi 5304 14 incidence incidence NN cord-335975-m6lkrehi 5304 15 density density NN cord-335975-m6lkrehi 5304 16 of of IN cord-335975-m6lkrehi 5304 17 21 21 CD cord-335975-m6lkrehi 5304 18 per per IN cord-335975-m6lkrehi 5304 19 1000 1000 CD cord-335975-m6lkrehi 5304 20 patient patient NN cord-335975-m6lkrehi 5304 21 - - HYPH cord-335975-m6lkrehi 5304 22 days day NNS cord-335975-m6lkrehi 5304 23 of of IN cord-335975-m6lkrehi 5304 24 mechanical mechanical JJ cord-335975-m6lkrehi 5304 25 ventilation ventilation NN cord-335975-m6lkrehi 5304 26 ( ( -LRB- cord-335975-m6lkrehi 5304 27 MV MV NNP cord-335975-m6lkrehi 5304 28 ) ) -RRB- cord-335975-m6lkrehi 5304 29 . . . cord-335975-m6lkrehi 5305 1 In in IN cord-335975-m6lkrehi 5305 2 univariate univariate JJ cord-335975-m6lkrehi 5305 3 analysis analysis NN cord-335975-m6lkrehi 5305 4 , , , cord-335975-m6lkrehi 5305 5 significant significant JJ cord-335975-m6lkrehi 5305 6 difference difference NN cord-335975-m6lkrehi 5305 7 was be VBD cord-335975-m6lkrehi 5305 8 found find VBN cord-335975-m6lkrehi 5305 9 between between IN cord-335975-m6lkrehi 5305 10 the the DT cord-335975-m6lkrehi 5305 11 group group NN cord-335975-m6lkrehi 5305 12 with with IN cord-335975-m6lkrehi 5305 13 VAP VAP NNP cord-335975-m6lkrehi 5305 14 and and CC cord-335975-m6lkrehi 5305 15 the the DT cord-335975-m6lkrehi 5305 16 group group NN cord-335975-m6lkrehi 5305 17 without without IN cord-335975-m6lkrehi 5305 18 VAP VAP NNP cord-335975-m6lkrehi 5305 19 regarding regard VBG cord-335975-m6lkrehi 5305 20 admission admission NN cord-335975-m6lkrehi 5305 21 for for IN cord-335975-m6lkrehi 5305 22 poly poly NNP cord-335975-m6lkrehi 5305 23 trauma trauma NN cord-335975-m6lkrehi 5305 24 , , , cord-335975-m6lkrehi 5305 25 acute acute JJ cord-335975-m6lkrehi 5305 26 respiratory respiratory JJ cord-335975-m6lkrehi 5305 27 failure failure NN cord-335975-m6lkrehi 5305 28 , , , cord-335975-m6lkrehi 5305 29 the the DT cord-335975-m6lkrehi 5305 30 concept concept NN cord-335975-m6lkrehi 5305 31 of of IN cord-335975-m6lkrehi 5305 32 prior prior JJ cord-335975-m6lkrehi 5305 33 antibiotic antibiotic JJ cord-335975-m6lkrehi 5305 34 therapy therapy NN cord-335975-m6lkrehi 5305 35 , , , cord-335975-m6lkrehi 5305 36 the the DT cord-335975-m6lkrehi 5305 37 need need NN cord-335975-m6lkrehi 5305 38 tracheostomy tracheostomy NN cord-335975-m6lkrehi 5305 39 , , , cord-335975-m6lkrehi 5305 40 the the DT cord-335975-m6lkrehi 5305 41 number number NN cord-335975-m6lkrehi 5305 42 of of IN cord-335975-m6lkrehi 5305 43 days day NNS cord-335975-m6lkrehi 5305 44 alive alive JJ cord-335975-m6lkrehi 5305 45 without without IN cord-335975-m6lkrehi 5305 46 antibiotics antibiotic NNS cord-335975-m6lkrehi 5305 47 and and CC cord-335975-m6lkrehi 5305 48 without without IN cord-335975-m6lkrehi 5305 49 MV MV NNP cord-335975-m6lkrehi 5305 50 , , , cord-335975-m6lkrehi 5305 51 the the DT cord-335975-m6lkrehi 5305 52 duration duration NN cord-335975-m6lkrehi 5305 53 of of IN cord-335975-m6lkrehi 5305 54 mechanical mechanical JJ cord-335975-m6lkrehi 5305 55 ventilation ventilation NN cord-335975-m6lkrehi 5305 56 , , , cord-335975-m6lkrehi 5305 57 length length NN cord-335975-m6lkrehi 5305 58 of of IN cord-335975-m6lkrehi 5305 59 stay stay NN cord-335975-m6lkrehi 5305 60 and and CC cord-335975-m6lkrehi 5305 61 mortality mortality NN cord-335975-m6lkrehi 5305 62 . . . cord-335975-m6lkrehi 5306 1 Multivariate multivariate JJ cord-335975-m6lkrehi 5306 2 analysis analysis NN cord-335975-m6lkrehi 5306 3 showed show VBD cord-335975-m6lkrehi 5306 4 that that IN cord-335975-m6lkrehi 5306 5 prior prior JJ cord-335975-m6lkrehi 5306 6 antibiotic antibiotic JJ cord-335975-m6lkrehi 5306 7 therapy therapy NN cord-335975-m6lkrehi 5306 8 and and CC cord-335975-m6lkrehi 5306 9 the the DT cord-335975-m6lkrehi 5306 10 use use NN cord-335975-m6lkrehi 5306 11 of of IN cord-335975-m6lkrehi 5306 12 tracheotomy tracheotomy NN cord-335975-m6lkrehi 5306 13 were be VBD cord-335975-m6lkrehi 5306 14 independent independent JJ cord-335975-m6lkrehi 5306 15 factors factor NNS cord-335975-m6lkrehi 5306 16 for for IN cord-335975-m6lkrehi 5306 17 developing develop VBG cord-335975-m6lkrehi 5306 18 VAP VAP NNP cord-335975-m6lkrehi 5306 19 . . . cord-335975-m6lkrehi 5307 1 Prolonged prolonged JJ cord-335975-m6lkrehi 5307 2 duration duration NN cord-335975-m6lkrehi 5307 3 of of IN cord-335975-m6lkrehi 5307 4 mechanical mechanical JJ cord-335975-m6lkrehi 5307 5 ventilation ventilation NN cord-335975-m6lkrehi 5307 6 was be VBD cord-335975-m6lkrehi 5307 7 an an DT cord-335975-m6lkrehi 5307 8 independent independent JJ cord-335975-m6lkrehi 5307 9 predictor predictor NN cord-335975-m6lkrehi 5307 10 of of IN cord-335975-m6lkrehi 5307 11 mortality mortality NN cord-335975-m6lkrehi 5307 12 in in IN cord-335975-m6lkrehi 5307 13 multivariate multivariate JJ cord-335975-m6lkrehi 5307 14 analysis analysis NN cord-335975-m6lkrehi 5307 15 with with IN cord-335975-m6lkrehi 5307 16 OR or CC cord-335975-m6lkrehi 5308 1 1.773 1.773 CD cord-335975-m6lkrehi 5308 2 + + SYM cord-335975-m6lkrehi 5308 3 95 95 CD cord-335975-m6lkrehi 5308 4 % % NN cord-335975-m6lkrehi 5308 5 [ [ -LRB- cord-335975-m6lkrehi 5308 6 1.202 1.202 CD cord-335975-m6lkrehi 5308 7 to to IN cord-335975-m6lkrehi 5308 8 2.616 2.616 CD cord-335975-m6lkrehi 5308 9 ] ] -RRB- cord-335975-m6lkrehi 5308 10 , , , cord-335975-m6lkrehi 5308 11 p p NN cord-335975-m6lkrehi 5308 12 = = SYM cord-335975-m6lkrehi 5308 13 0.04 0.04 CD cord-335975-m6lkrehi 5308 14 . . . cord-335975-m6lkrehi 5309 1 The the DT cord-335975-m6lkrehi 5309 2 occurrence occurrence NN cord-335975-m6lkrehi 5309 3 of of IN cord-335975-m6lkrehi 5309 4 VAP VAP NNP cord-335975-m6lkrehi 5309 5 was be VBD cord-335975-m6lkrehi 5309 6 not not RB cord-335975-m6lkrehi 5309 7 an an DT cord-335975-m6lkrehi 5309 8 independent independent JJ cord-335975-m6lkrehi 5309 9 predictor predictor NN cord-335975-m6lkrehi 5309 10 to to IN cord-335975-m6lkrehi 5309 11 mortality mortality NN cord-335975-m6lkrehi 5309 12 . . . cord-335975-m6lkrehi 5310 1 Conclusion conclusion NN cord-335975-m6lkrehi 5310 2 : : : cord-335975-m6lkrehi 5311 1 The the DT cord-335975-m6lkrehi 5311 2 incidence incidence NN cord-335975-m6lkrehi 5311 3 of of IN cord-335975-m6lkrehi 5311 4 VAP VAP NNP cord-335975-m6lkrehi 5311 5 found find VBN cord-335975-m6lkrehi 5311 6 in in IN cord-335975-m6lkrehi 5311 7 our -PRON- PRP$ cord-335975-m6lkrehi 5311 8 study study NN cord-335975-m6lkrehi 5311 9 is be VBZ cord-335975-m6lkrehi 5311 10 similar similar JJ cord-335975-m6lkrehi 5311 11 to to IN cord-335975-m6lkrehi 5311 12 that that DT cord-335975-m6lkrehi 5311 13 found find VBN cord-335975-m6lkrehi 5311 14 in in IN cord-335975-m6lkrehi 5311 15 the the DT cord-335975-m6lkrehi 5311 16 literature literature NN cord-335975-m6lkrehi 5311 17 . . . cord-335975-m6lkrehi 5312 1 An an DT cord-335975-m6lkrehi 5312 2 active active JJ cord-335975-m6lkrehi 5312 3 strategy strategy NN cord-335975-m6lkrehi 5312 4 of of IN cord-335975-m6lkrehi 5312 5 rationalizing rationalize VBG cord-335975-m6lkrehi 5312 6 the the DT cord-335975-m6lkrehi 5312 7 prescription prescription NN cord-335975-m6lkrehi 5312 8 of of IN cord-335975-m6lkrehi 5312 9 antibiotics antibiotic NNS cord-335975-m6lkrehi 5312 10 in in IN cord-335975-m6lkrehi 5312 11 intensive intensive JJ cord-335975-m6lkrehi 5312 12 care care NN cord-335975-m6lkrehi 5312 13 units unit NNS cord-335975-m6lkrehi 5312 14 and and CC cord-335975-m6lkrehi 5312 15 a a DT cord-335975-m6lkrehi 5312 16 well well RB cord-335975-m6lkrehi 5312 17 - - HYPH cord-335975-m6lkrehi 5312 18 defined define VBN cord-335975-m6lkrehi 5312 19 protocol protocol NN cord-335975-m6lkrehi 5312 20 of of IN cord-335975-m6lkrehi 5312 21 weaning wean VBG cord-335975-m6lkrehi 5312 22 from from IN cord-335975-m6lkrehi 5312 23 mechanical mechanical JJ cord-335975-m6lkrehi 5312 24 ventilation ventilation NN cord-335975-m6lkrehi 5312 25 may may MD cord-335975-m6lkrehi 5312 26 reduce reduce VB cord-335975-m6lkrehi 5312 27 the the DT cord-335975-m6lkrehi 5312 28 incidence incidence NN cord-335975-m6lkrehi 5312 29 of of IN cord-335975-m6lkrehi 5312 30 VAP VAP NNP cord-335975-m6lkrehi 5312 31 and and CC cord-335975-m6lkrehi 5312 32 over over RB cord-335975-m6lkrehi 5312 33 - - HYPH cord-335975-m6lkrehi 5312 34 all all DT cord-335975-m6lkrehi 5312 35 morbidity morbidity NN cord-335975-m6lkrehi 5312 36 and and CC cord-335975-m6lkrehi 5312 37 mortality mortality NN cord-335975-m6lkrehi 5312 38 . . . cord-335975-m6lkrehi 5313 1 Introduction introduction NN cord-335975-m6lkrehi 5313 2 : : : cord-335975-m6lkrehi 5314 1 Hyperoxemia Hyperoxemia NNP cord-335975-m6lkrehi 5314 2 is be VBZ cord-335975-m6lkrehi 5314 3 common common JJ cord-335975-m6lkrehi 5314 4 in in IN cord-335975-m6lkrehi 5314 5 critically critically RB cord-335975-m6lkrehi 5314 6 ill ill JJ cord-335975-m6lkrehi 5314 7 patients patient NNS cord-335975-m6lkrehi 5314 8 . . . cord-335975-m6lkrehi 5315 1 Hyperoxic hyperoxic JJ cord-335975-m6lkrehi 5315 2 acute acute JJ cord-335975-m6lkrehi 5315 3 lung lung NN cord-335975-m6lkrehi 5315 4 injury injury NN cord-335975-m6lkrehi 5315 5 ( ( -LRB- cord-335975-m6lkrehi 5315 6 HALI HALI NNP cord-335975-m6lkrehi 5315 7 ) ) -RRB- cord-335975-m6lkrehi 5315 8 , , , cord-335975-m6lkrehi 5315 9 reduced reduce VBN cord-335975-m6lkrehi 5315 10 bacterial bacterial JJ cord-335975-m6lkrehi 5315 11 clearance clearance NN cord-335975-m6lkrehi 5315 12 , , , cord-335975-m6lkrehi 5315 13 atelectasis atelectasis NN cord-335975-m6lkrehi 5315 14 and and CC cord-335975-m6lkrehi 5315 15 higher high JJR cord-335975-m6lkrehi 5315 16 mortality mortality NN cord-335975-m6lkrehi 5315 17 rates rate NNS cord-335975-m6lkrehi 5315 18 were be VBD cord-335975-m6lkrehi 5315 19 reported report VBN cord-335975-m6lkrehi 5315 20 in in IN cord-335975-m6lkrehi 5315 21 mechanically mechanically RB cord-335975-m6lkrehi 5315 22 ventilated ventilate VBN cord-335975-m6lkrehi 5315 23 patients patient NNS cord-335975-m6lkrehi 5315 24 with with IN cord-335975-m6lkrehi 5315 25 hyperoxemia hyperoxemia NNP cord-335975-m6lkrehi 5315 26 . . . cord-335975-m6lkrehi 5316 1 The the DT cord-335975-m6lkrehi 5316 2 aim aim NN cord-335975-m6lkrehi 5316 3 of of IN cord-335975-m6lkrehi 5316 4 our -PRON- PRP$ cord-335975-m6lkrehi 5316 5 study study NN cord-335975-m6lkrehi 5316 6 was be VBD cord-335975-m6lkrehi 5316 7 to to TO cord-335975-m6lkrehi 5316 8 determine determine VB cord-335975-m6lkrehi 5316 9 the the DT cord-335975-m6lkrehi 5316 10 relationship relationship NN cord-335975-m6lkrehi 5316 11 between between IN cord-335975-m6lkrehi 5316 12 hyperoxemia hyperoxemia NN cord-335975-m6lkrehi 5316 13 and and CC cord-335975-m6lkrehi 5316 14 mortality mortality NN cord-335975-m6lkrehi 5316 15 in in IN cord-335975-m6lkrehi 5316 16 patients patient NNS cord-335975-m6lkrehi 5316 17 with with IN cord-335975-m6lkrehi 5316 18 ventilator ventilator NN cord-335975-m6lkrehi 5316 19 - - HYPH cord-335975-m6lkrehi 5316 20 associated associate VBN cord-335975-m6lkrehi 5316 21 pneumonia pneumonia NN cord-335975-m6lkrehi 5316 22 ( ( -LRB- cord-335975-m6lkrehi 5316 23 VAP VAP NNP cord-335975-m6lkrehi 5316 24 ) ) -RRB- cord-335975-m6lkrehi 5316 25 . . . cord-335975-m6lkrehi 5317 1 This this DT cord-335975-m6lkrehi 5317 2 retrospective retrospective JJ cord-335975-m6lkrehi 5317 3 observational observational JJ cord-335975-m6lkrehi 5317 4 single single JJ cord-335975-m6lkrehi 5317 5 center center NN cord-335975-m6lkrehi 5317 6 study study NN cord-335975-m6lkrehi 5317 7 was be VBD cord-335975-m6lkrehi 5317 8 performed perform VBN cord-335975-m6lkrehi 5317 9 in in IN cord-335975-m6lkrehi 5317 10 a a DT cord-335975-m6lkrehi 5317 11 50-bed 50-bed CD cord-335975-m6lkrehi 5317 12 mixed mixed JJ cord-335975-m6lkrehi 5317 13 intensive intensive JJ cord-335975-m6lkrehi 5317 14 care care NN cord-335975-m6lkrehi 5317 15 unit unit NN cord-335975-m6lkrehi 5317 16 ( ( -LRB- cord-335975-m6lkrehi 5317 17 ICU ICU NNP cord-335975-m6lkrehi 5317 18 ) ) -RRB- cord-335975-m6lkrehi 5317 19 during during IN cord-335975-m6lkrehi 5317 20 a a DT cord-335975-m6lkrehi 5317 21 1-year 1-year CD cord-335975-m6lkrehi 5317 22 period period NN cord-335975-m6lkrehi 5317 23 , , , cord-335975-m6lkrehi 5317 24 from from IN cord-335975-m6lkrehi 5317 25 January January NNP cord-335975-m6lkrehi 5317 26 2016 2016 CD cord-335975-m6lkrehi 5317 27 to to IN cord-335975-m6lkrehi 5317 28 January January NNP cord-335975-m6lkrehi 5317 29 2017 2017 CD cord-335975-m6lkrehi 5317 30 . . . cord-335975-m6lkrehi 5318 1 All all DT cord-335975-m6lkrehi 5318 2 patients patient NNS cord-335975-m6lkrehi 5318 3 with with IN cord-335975-m6lkrehi 5318 4 VAP VAP NNP cord-335975-m6lkrehi 5318 5 were be VBD cord-335975-m6lkrehi 5318 6 included include VBN cord-335975-m6lkrehi 5318 7 . . . cord-335975-m6lkrehi 5319 1 VAP VAP NNP cord-335975-m6lkrehi 5319 2 was be VBD cord-335975-m6lkrehi 5319 3 defined define VBN cord-335975-m6lkrehi 5319 4 using use VBG cord-335975-m6lkrehi 5319 5 clinical clinical JJ cord-335975-m6lkrehi 5319 6 , , , cord-335975-m6lkrehi 5319 7 radiological radiological JJ cord-335975-m6lkrehi 5319 8 and and CC cord-335975-m6lkrehi 5319 9 quantitative quantitative JJ cord-335975-m6lkrehi 5319 10 microbiological microbiological JJ cord-335975-m6lkrehi 5319 11 criteria criterion NNS cord-335975-m6lkrehi 5319 12 . . . cord-335975-m6lkrehi 5320 1 Hyperoxemia Hyperoxemia NNP cord-335975-m6lkrehi 5320 2 was be VBD cord-335975-m6lkrehi 5320 3 defined define VBN cord-335975-m6lkrehi 5320 4 as as IN cord-335975-m6lkrehi 5320 5 peripheral peripheral JJ cord-335975-m6lkrehi 5320 6 capillary capillary JJ cord-335975-m6lkrehi 5320 7 oxygen oxygen NN cord-335975-m6lkrehi 5320 8 saturation saturation NN cord-335975-m6lkrehi 5320 9 - - HYPH cord-335975-m6lkrehi 5320 10 SpO2 SpO2 NNS cord-335975-m6lkrehi 5320 11 ≥ ≥ CD cord-335975-m6lkrehi 5320 12 98 98 CD cord-335975-m6lkrehi 5320 13 % % NN cord-335975-m6lkrehi 5320 14 . . . cord-335975-m6lkrehi 5321 1 SpO2 SpO2 NNP cord-335975-m6lkrehi 5321 2 was be VBD cord-335975-m6lkrehi 5321 3 hourly hourly RB cord-335975-m6lkrehi 5321 4 collected collect VBN cord-335975-m6lkrehi 5321 5 in in IN cord-335975-m6lkrehi 5321 6 all all DT cord-335975-m6lkrehi 5321 7 study study NN cord-335975-m6lkrehi 5321 8 patients patient NNS cord-335975-m6lkrehi 5321 9 during during IN cord-335975-m6lkrehi 5321 10 the the DT cord-335975-m6lkrehi 5321 11 whole whole JJ cord-335975-m6lkrehi 5321 12 period period NN cord-335975-m6lkrehi 5321 13 of of IN cord-335975-m6lkrehi 5321 14 mechanical mechanical JJ cord-335975-m6lkrehi 5321 15 ventilation ventilation NN cord-335975-m6lkrehi 5321 16 . . . cord-335975-m6lkrehi 5322 1 The the DT cord-335975-m6lkrehi 5322 2 daily daily JJ cord-335975-m6lkrehi 5322 3 percentage percentage NN cord-335975-m6lkrehi 5322 4 of of IN cord-335975-m6lkrehi 5322 5 time time NN cord-335975-m6lkrehi 5322 6 spent spend VBN cord-335975-m6lkrehi 5322 7 with with IN cord-335975-m6lkrehi 5322 8 hyperoxemia hyperoxemia NNP cord-335975-m6lkrehi 5322 9 was be VBD cord-335975-m6lkrehi 5322 10 calculated calculate VBN cord-335975-m6lkrehi 5322 11 as as IN cord-335975-m6lkrehi 5322 12 the the DT cord-335975-m6lkrehi 5322 13 number number NN cord-335975-m6lkrehi 5322 14 of of IN cord-335975-m6lkrehi 5322 15 hours hour NNS cord-335975-m6lkrehi 5322 16 with with IN cord-335975-m6lkrehi 5322 17 hyperoxemia hyperoxemia NN cord-335975-m6lkrehi 5322 18 divided divide VBN cord-335975-m6lkrehi 5322 19 by by IN cord-335975-m6lkrehi 5322 20 24 24 CD cord-335975-m6lkrehi 5322 21 . . . cord-335975-m6lkrehi 5323 1 Results result NNS cord-335975-m6lkrehi 5323 2 : : : cord-335975-m6lkrehi 5324 1 Among among IN cord-335975-m6lkrehi 5324 2 the the DT cord-335975-m6lkrehi 5324 3 547 547 CD cord-335975-m6lkrehi 5324 4 patients patient NNS cord-335975-m6lkrehi 5324 5 receiving receive VBG cord-335975-m6lkrehi 5324 6 invasive invasive JJ cord-335975-m6lkrehi 5324 7 mechanical mechanical JJ cord-335975-m6lkrehi 5324 8 ventilation ventilation NN cord-335975-m6lkrehi 5324 9 ( ( -LRB- cord-335975-m6lkrehi 5324 10 MV MV NNP cord-335975-m6lkrehi 5324 11 ) ) -RRB- cord-335975-m6lkrehi 5324 12 > > NFP cord-335975-m6lkrehi 5324 13 48 48 CD cord-335975-m6lkrehi 5324 14 h h NN cord-335975-m6lkrehi 5324 15 during during IN cord-335975-m6lkrehi 5324 16 the the DT cord-335975-m6lkrehi 5324 17 study study NN cord-335975-m6lkrehi 5324 18 period period NN cord-335975-m6lkrehi 5324 19 , , , cord-335975-m6lkrehi 5324 20 the the DT cord-335975-m6lkrehi 5324 21 incidence incidence NN cord-335975-m6lkrehi 5324 22 rate rate NN cord-335975-m6lkrehi 5324 23 of of IN cord-335975-m6lkrehi 5324 24 VAP VAP NNP cord-335975-m6lkrehi 5324 25 was be VBD cord-335975-m6lkrehi 5324 26 11.7 11.7 CD cord-335975-m6lkrehi 5324 27 VAP VAP NNP cord-335975-m6lkrehi 5324 28 per per IN cord-335975-m6lkrehi 5324 29 1000 1000 CD cord-335975-m6lkrehi 5324 30 ventilator ventilator NN cord-335975-m6lkrehi 5324 31 - - HYPH cord-335975-m6lkrehi 5324 32 days day NNS cord-335975-m6lkrehi 5324 33 . . . cord-335975-m6lkrehi 5325 1 93 93 CD cord-335975-m6lkrehi 5325 2 patients patient NNS cord-335975-m6lkrehi 5325 3 developed develop VBD cord-335975-m6lkrehi 5325 4 VAP VAP NNP cord-335975-m6lkrehi 5325 5 and and CC cord-335975-m6lkrehi 5325 6 were be VBD cord-335975-m6lkrehi 5325 7 all all DT cord-335975-m6lkrehi 5325 8 included include VBN cord-335975-m6lkrehi 5325 9 in in IN cord-335975-m6lkrehi 5325 10 this this DT cord-335975-m6lkrehi 5325 11 study study NN cord-335975-m6lkrehi 5325 12 . . . cord-335975-m6lkrehi 5326 1 30 30 CD cord-335975-m6lkrehi 5326 2 ( ( -LRB- cord-335975-m6lkrehi 5326 3 32 32 CD cord-335975-m6lkrehi 5326 4 % % NN cord-335975-m6lkrehi 5326 5 ) ) -RRB- cord-335975-m6lkrehi 5327 1 VAP VAP NNP cord-335975-m6lkrehi 5327 2 patients patient NNS cord-335975-m6lkrehi 5327 3 died die VBD cord-335975-m6lkrehi 5327 4 in in IN cord-335975-m6lkrehi 5327 5 the the DT cord-335975-m6lkrehi 5327 6 ICU ICU NNP cord-335975-m6lkrehi 5327 7 . . . cord-335975-m6lkrehi 5328 1 The the DT cord-335975-m6lkrehi 5328 2 mean mean JJ cord-335975-m6lkrehi 5328 3 daily daily JJ cord-335975-m6lkrehi 5328 4 time time NN cord-335975-m6lkrehi 5328 5 spent spend VBN cord-335975-m6lkrehi 5328 6 with with IN cord-335975-m6lkrehi 5328 7 hyperoxemia hyperoxemia NNP cord-335975-m6lkrehi 5328 8 was be VBD cord-335975-m6lkrehi 5328 9 45 45 CD cord-335975-m6lkrehi 5328 10 % % NN cord-335975-m6lkrehi 5328 11 . . . cord-335975-m6lkrehi 5329 1 No no DT cord-335975-m6lkrehi 5329 2 significant significant JJ cord-335975-m6lkrehi 5329 3 difference difference NN cord-335975-m6lkrehi 5329 4 was be VBD cord-335975-m6lkrehi 5329 5 found find VBN cord-335975-m6lkrehi 5329 6 in in IN cord-335975-m6lkrehi 5329 7 mean mean JJ cord-335975-m6lkrehi 5329 8 percentage percentage NN cord-335975-m6lkrehi 5329 9 of of IN cord-335975-m6lkrehi 5329 10 time time NN cord-335975-m6lkrehi 5329 11 spent spend VBN cord-335975-m6lkrehi 5329 12 with with IN cord-335975-m6lkrehi 5329 13 hyperoxemia hyperoxemia NN cord-335975-m6lkrehi 5329 14 between between IN cord-335975-m6lkrehi 5329 15 survivors survivor NNS cord-335975-m6lkrehi 5329 16 and and CC cord-335975-m6lkrehi 5329 17 nonsurvivors nonsurvivor NNS cord-335975-m6lkrehi 5329 18 at at IN cord-335975-m6lkrehi 5329 19 ICU ICU NNP cord-335975-m6lkrehi 5329 20 admission admission NN cord-335975-m6lkrehi 5329 21 , , , cord-335975-m6lkrehi 5329 22 before before RB cord-335975-m6lkrehi 5329 23 , , , cord-335975-m6lkrehi 5329 24 after after IN cord-335975-m6lkrehi 5329 25 or or CC cord-335975-m6lkrehi 5329 26 at at IN cord-335975-m6lkrehi 5329 27 the the DT cord-335975-m6lkrehi 5329 28 VAP VAP NNP cord-335975-m6lkrehi 5329 29 diagnosis diagnosis NN cord-335975-m6lkrehi 5329 30 . . . cord-335975-m6lkrehi 5330 1 Age age NN cord-335975-m6lkrehi 5330 2 , , , cord-335975-m6lkrehi 5330 3 and and CC cord-335975-m6lkrehi 5330 4 sequential sequential JJ cord-335975-m6lkrehi 5330 5 organ organ NN cord-335975-m6lkrehi 5330 6 dysfunction dysfunction NN cord-335975-m6lkrehi 5330 7 assessment assessment NN cord-335975-m6lkrehi 5330 8 ( ( -LRB- cord-335975-m6lkrehi 5330 9 SOFA SOFA NNP cord-335975-m6lkrehi 5330 10 ) ) -RRB- cord-335975-m6lkrehi 5330 11 at at IN cord-335975-m6lkrehi 5330 12 the the DT cord-335975-m6lkrehi 5330 13 day day NN cord-335975-m6lkrehi 5330 14 of of IN cord-335975-m6lkrehi 5330 15 VAP VAP NNP cord-335975-m6lkrehi 5330 16 occurrence occurrence NN cord-335975-m6lkrehi 5330 17 were be VBD cord-335975-m6lkrehi 5330 18 independently independently RB cord-335975-m6lkrehi 5330 19 associated associate VBN cord-335975-m6lkrehi 5330 20 with with IN cord-335975-m6lkrehi 5330 21 ICU ICU NNP cord-335975-m6lkrehi 5330 22 mortality mortality NN cord-335975-m6lkrehi 5330 23 ( ( -LRB- cord-335975-m6lkrehi 5330 24 OR or CC cord-335975-m6lkrehi 5330 25 1.04 1.04 CD cord-335975-m6lkrehi 5330 26 [ [ -LRB- cord-335975-m6lkrehi 5330 27 1.007 1.007 CD cord-335975-m6lkrehi 5330 28 - - SYM cord-335975-m6lkrehi 5330 29 1.075 1.075 CD cord-335975-m6lkrehi 5330 30 ] ] -RRB- cord-335975-m6lkrehi 5330 31 per per IN cord-335975-m6lkrehi 5330 32 year year NN cord-335975-m6lkrehi 5330 33 , , , cord-335975-m6lkrehi 5330 34 p p NN cord-335975-m6lkrehi 5330 35 = = SYM cord-335975-m6lkrehi 5330 36 0.02 0.02 CD cord-335975-m6lkrehi 5330 37 + + SYM cord-335975-m6lkrehi 5330 38 1.19 1.19 CD cord-335975-m6lkrehi 5330 39 [ [ -LRB- cord-335975-m6lkrehi 5330 40 1.064 1.064 CD cord-335975-m6lkrehi 5330 41 - - HYPH cord-335975-m6lkrehi 5330 42 1.339 1.339 CD cord-335975-m6lkrehi 5330 43 ] ] -RRB- cord-335975-m6lkrehi 5330 44 per per IN cord-335975-m6lkrehi 5330 45 point point NN cord-335975-m6lkrehi 5330 46 , , , cord-335975-m6lkrehi 5330 47 p p NN cord-335975-m6lkrehi 5330 48 = = SYM cord-335975-m6lkrehi 5330 49 0.003 0.003 CD cord-335975-m6lkrehi 5330 50 + + CC cord-335975-m6lkrehi 5330 51 respectively respectively RB cord-335975-m6lkrehi 5330 52 ) ) -RRB- cord-335975-m6lkrehi 5330 53 . . . cord-335975-m6lkrehi 5331 1 No no DT cord-335975-m6lkrehi 5331 2 significant significant JJ cord-335975-m6lkrehi 5331 3 impact impact NN cord-335975-m6lkrehi 5331 4 was be VBD cord-335975-m6lkrehi 5331 5 found find VBN cord-335975-m6lkrehi 5331 6 of of IN cord-335975-m6lkrehi 5331 7 time time NN cord-335975-m6lkrehi 5331 8 spent spend VBN cord-335975-m6lkrehi 5331 9 with with IN cord-335975-m6lkrehi 5331 10 hyperoxemia hyperoxemia NN cord-335975-m6lkrehi 5331 11 before before IN cord-335975-m6lkrehi 5331 12 VAP VAP NNP cord-335975-m6lkrehi 5331 13 occurrence occurrence NN cord-335975-m6lkrehi 5331 14 , , , cord-335975-m6lkrehi 5331 15 on on IN cord-335975-m6lkrehi 5331 16 MV MV NNP cord-335975-m6lkrehi 5331 17 free free JJ cord-335975-m6lkrehi 5331 18 days day NNS cord-335975-m6lkrehi 5331 19 , , , cord-335975-m6lkrehi 5331 20 or or CC cord-335975-m6lkrehi 5331 21 ICU ICU NNP cord-335975-m6lkrehi 5331 22 length length NN cord-335975-m6lkrehi 5331 23 of of IN cord-335975-m6lkrehi 5331 24 stay stay NN cord-335975-m6lkrehi 5331 25 ( ( -LRB- cord-335975-m6lkrehi 5331 26 Fig fig NN cord-335975-m6lkrehi 5331 27 . . . cord-335975-m6lkrehi 5331 28 1 1 CD cord-335975-m6lkrehi 5331 29 ) ) -RRB- cord-335975-m6lkrehi 5331 30 . . . cord-335975-m6lkrehi 5332 1 Discussion discussion NN cord-335975-m6lkrehi 5332 2 : : : cord-335975-m6lkrehi 5333 1 Several several JJ cord-335975-m6lkrehi 5333 2 potential potential JJ cord-335975-m6lkrehi 5333 3 explanations explanation NNS cord-335975-m6lkrehi 5333 4 could could MD cord-335975-m6lkrehi 5333 5 be be VB cord-335975-m6lkrehi 5333 6 provided provide VBN cord-335975-m6lkrehi 5333 7 for for IN cord-335975-m6lkrehi 5333 8 the the DT cord-335975-m6lkrehi 5333 9 absence absence NN cord-335975-m6lkrehi 5333 10 of of IN cord-335975-m6lkrehi 5333 11 negative negative JJ cord-335975-m6lkrehi 5333 12 impact impact NN cord-335975-m6lkrehi 5333 13 on on IN cord-335975-m6lkrehi 5333 14 mortality mortality NN cord-335975-m6lkrehi 5333 15 of of IN cord-335975-m6lkrehi 5333 16 hyperoxemia hyperoxemia NN cord-335975-m6lkrehi 5333 17 . . . cord-335975-m6lkrehi 5334 1 First first RB cord-335975-m6lkrehi 5334 2 , , , cord-335975-m6lkrehi 5334 3 the the DT cord-335975-m6lkrehi 5334 4 definition definition NN cord-335975-m6lkrehi 5334 5 used use VBN cord-335975-m6lkrehi 5334 6 for for IN cord-335975-m6lkrehi 5334 7 hyperoxemia hyperoxemia NNP cord-335975-m6lkrehi 5334 8 could could MD cord-335975-m6lkrehi 5334 9 be be VB cord-335975-m6lkrehi 5334 10 debated debate VBN cord-335975-m6lkrehi 5334 11 , , , cord-335975-m6lkrehi 5334 12 as as IN cord-335975-m6lkrehi 5334 13 no no DT cord-335975-m6lkrehi 5334 14 consensus consensus NN cord-335975-m6lkrehi 5334 15 exists exist VBZ cord-335975-m6lkrehi 5334 16 . . . cord-335975-m6lkrehi 5335 1 However however RB cord-335975-m6lkrehi 5335 2 , , , cord-335975-m6lkrehi 5335 3 the the DT cord-335975-m6lkrehi 5335 4 definition definition NN cord-335975-m6lkrehi 5335 5 used use VBN cord-335975-m6lkrehi 5335 6 in in IN cord-335975-m6lkrehi 5335 7 our -PRON- PRP$ cord-335975-m6lkrehi 5335 8 study study NN cord-335975-m6lkrehi 5335 9 was be VBD cord-335975-m6lkrehi 5335 10 rather rather RB cord-335975-m6lkrehi 5335 11 stringent stringent JJ cord-335975-m6lkrehi 5335 12 and and CC cord-335975-m6lkrehi 5335 13 the the DT cord-335975-m6lkrehi 5335 14 mean mean JJ cord-335975-m6lkrehi 5335 15 daily daily JJ cord-335975-m6lkrehi 5335 16 time time NN cord-335975-m6lkrehi 5335 17 spent spend VBN cord-335975-m6lkrehi 5335 18 with with IN cord-335975-m6lkrehi 5335 19 hyperoxemia hyperoxemia NNP cord-335975-m6lkrehi 5335 20 was be VBD cord-335975-m6lkrehi 5335 21 in in IN cord-335975-m6lkrehi 5335 22 line line NN cord-335975-m6lkrehi 5335 23 with with IN cord-335975-m6lkrehi 5335 24 that that DT cord-335975-m6lkrehi 5335 25 reported report VBN cord-335975-m6lkrehi 5335 26 by by IN cord-335975-m6lkrehi 5335 27 studies study NNS cord-335975-m6lkrehi 5335 28 . . . cord-335975-m6lkrehi 5336 1 Second second RB cord-335975-m6lkrehi 5336 2 , , , cord-335975-m6lkrehi 5336 3 the the DT cord-335975-m6lkrehi 5336 4 impact impact NN cord-335975-m6lkrehi 5336 5 of of IN cord-335975-m6lkrehi 5336 6 hyperoxemia hyperoxemia NN cord-335975-m6lkrehi 5336 7 on on IN cord-335975-m6lkrehi 5336 8 mortality mortality NN cord-335975-m6lkrehi 5336 9 could could MD cord-335975-m6lkrehi 5336 10 have have VB cord-335975-m6lkrehi 5336 11 been be VBN cord-335975-m6lkrehi 5336 12 confounded confound VBN cord-335975-m6lkrehi 5336 13 by by IN cord-335975-m6lkrehi 5336 14 a a DT cord-335975-m6lkrehi 5336 15 large large JJ cord-335975-m6lkrehi 5336 16 number number NN cord-335975-m6lkrehi 5336 17 of of IN cord-335975-m6lkrehi 5336 18 patients patient NNS cord-335975-m6lkrehi 5336 19 included include VBN cord-335975-m6lkrehi 5336 20 with with IN cord-335975-m6lkrehi 5336 21 pulmonary pulmonary JJ cord-335975-m6lkrehi 5336 22 lesions lesion NNS cord-335975-m6lkrehi 5336 23 at at IN cord-335975-m6lkrehi 5336 24 admission admission NN cord-335975-m6lkrehi 5336 25 . . . cord-335975-m6lkrehi 5337 1 Third third RB cord-335975-m6lkrehi 5337 2 , , , cord-335975-m6lkrehi 5337 3 the the DT cord-335975-m6lkrehi 5337 4 number number NN cord-335975-m6lkrehi 5337 5 of of IN cord-335975-m6lkrehi 5337 6 included include VBN cord-335975-m6lkrehi 5337 7 patients patient NNS cord-335975-m6lkrehi 5337 8 was be VBD cord-335975-m6lkrehi 5337 9 small small JJ cord-335975-m6lkrehi 5337 10 . . . cord-335975-m6lkrehi 5338 1 Conclusion conclusion NN cord-335975-m6lkrehi 5338 2 : : : cord-335975-m6lkrehi 5339 1 Our -PRON- PRP$ cord-335975-m6lkrehi 5339 2 study study NN cord-335975-m6lkrehi 5339 3 found find VBD cord-335975-m6lkrehi 5339 4 no no DT cord-335975-m6lkrehi 5339 5 significant significant JJ cord-335975-m6lkrehi 5339 6 impact impact NN cord-335975-m6lkrehi 5339 7 of of IN cord-335975-m6lkrehi 5339 8 hyperoxemia hyperoxemia NN cord-335975-m6lkrehi 5339 9 at at IN cord-335975-m6lkrehi 5339 10 ICU ICU NNP cord-335975-m6lkrehi 5339 11 admission admission NN cord-335975-m6lkrehi 5339 12 , , , cord-335975-m6lkrehi 5339 13 or or CC cord-335975-m6lkrehi 5339 14 during during IN cord-335975-m6lkrehi 5339 15 ICU ICU NNP cord-335975-m6lkrehi 5339 16 stay stay NN cord-335975-m6lkrehi 5339 17 , , , cord-335975-m6lkrehi 5339 18 on on IN cord-335975-m6lkrehi 5339 19 ICU ICU NNP cord-335975-m6lkrehi 5339 20 mortality mortality NN cord-335975-m6lkrehi 5339 21 in in IN cord-335975-m6lkrehi 5339 22 VAP VAP NNP cord-335975-m6lkrehi 5339 23 patient patient NN cord-335975-m6lkrehi 5339 24 . . . cord-335975-m6lkrehi 5340 1 Results result NNS cord-335975-m6lkrehi 5340 2 : : : cord-335975-m6lkrehi 5340 3 128 128 CD cord-335975-m6lkrehi 5340 4 patients patient NNS cord-335975-m6lkrehi 5340 5 collected collect VBN cord-335975-m6lkrehi 5340 6 during during IN cord-335975-m6lkrehi 5340 7 this this DT cord-335975-m6lkrehi 5340 8 period period NN cord-335975-m6lkrehi 5340 9 . . . cord-335975-m6lkrehi 5341 1 228 228 CD cord-335975-m6lkrehi 5341 2 distal distal JJ cord-335975-m6lkrehi 5341 3 protected protect VBN cord-335975-m6lkrehi 5341 4 specimens specimen NNS cord-335975-m6lkrehi 5341 5 were be VBD cord-335975-m6lkrehi 5341 6 performed perform VBN cord-335975-m6lkrehi 5341 7 in in IN cord-335975-m6lkrehi 5341 8 patients patient NNS cord-335975-m6lkrehi 5341 9 suspected suspect VBN cord-335975-m6lkrehi 5341 10 of of IN cord-335975-m6lkrehi 5341 11 VAP VAP NNP cord-335975-m6lkrehi 5341 12 . . . cord-335975-m6lkrehi 5342 1 The the DT cord-335975-m6lkrehi 5342 2 diagnosis diagnosis NN cord-335975-m6lkrehi 5342 3 of of IN cord-335975-m6lkrehi 5342 4 this this DT cord-335975-m6lkrehi 5342 5 infection infection NN cord-335975-m6lkrehi 5342 6 was be VBD cord-335975-m6lkrehi 5342 7 made make VBN cord-335975-m6lkrehi 5342 8 . . . cord-335975-m6lkrehi 5343 1 In in IN cord-335975-m6lkrehi 5343 2 55 55 CD cord-335975-m6lkrehi 5343 3 of of IN cord-335975-m6lkrehi 5343 4 them -PRON- PRP cord-335975-m6lkrehi 5343 5 with with IN cord-335975-m6lkrehi 5343 6 other other JJ cord-335975-m6lkrehi 5343 7 diagnostic diagnostic JJ cord-335975-m6lkrehi 5343 8 criteria criterion NNS cord-335975-m6lkrehi 5343 9 ( ( -LRB- cord-335975-m6lkrehi 5343 10 43 43 CD cord-335975-m6lkrehi 5343 11 % % NN cord-335975-m6lkrehi 5343 12 ) ) -RRB- cord-335975-m6lkrehi 5343 13 which which WDT cord-335975-m6lkrehi 5343 14 represents represent VBZ cord-335975-m6lkrehi 5343 15 an an DT cord-335975-m6lkrehi 5343 16 incidence incidence NN cord-335975-m6lkrehi 5343 17 density density NN cord-335975-m6lkrehi 5343 18 of of IN cord-335975-m6lkrehi 5343 19 8.2 8.2 CD cord-335975-m6lkrehi 5343 20 per per IN cord-335975-m6lkrehi 5343 21 1,000 1,000 CD cord-335975-m6lkrehi 5343 22 days.80 days.80 NNP cord-335975-m6lkrehi 5343 23 % % NN cord-335975-m6lkrehi 5343 24 of of IN cord-335975-m6lkrehi 5343 25 PAVM PAVM NNP cord-335975-m6lkrehi 5343 26 are be VBP cord-335975-m6lkrehi 5343 27 due due JJ cord-335975-m6lkrehi 5343 28 to to TO cord-335975-m6lkrehi 5343 29 gram gram VB cord-335975-m6lkrehi 5343 30 negative negative JJ cord-335975-m6lkrehi 5343 31 bacilli bacilli NN cord-335975-m6lkrehi 5343 32 . . . cord-335975-m6lkrehi 5344 1 The the DT cord-335975-m6lkrehi 5344 2 first first JJ cord-335975-m6lkrehi 5344 3 germ germ NN cord-335975-m6lkrehi 5344 4 involved involve VBN cord-335975-m6lkrehi 5344 5 in in IN cord-335975-m6lkrehi 5344 6 our -PRON- PRP$ cord-335975-m6lkrehi 5344 7 series series NN cord-335975-m6lkrehi 5344 8 and and CC cord-335975-m6lkrehi 5344 9 pseudomonas pseudomonas NNP cord-335975-m6lkrehi 5344 10 ( ( -LRB- cord-335975-m6lkrehi 5344 11 30 30 CD cord-335975-m6lkrehi 5344 12 % % NN cord-335975-m6lkrehi 5344 13 ) ) -RRB- cord-335975-m6lkrehi 5344 14 followed follow VBN cord-335975-m6lkrehi 5344 15 by by IN cord-335975-m6lkrehi 5344 16 klebsielles klebsielles NNP cord-335975-m6lkrehi 5344 17 ( ( -LRB- cord-335975-m6lkrehi 5344 18 15 15 CD cord-335975-m6lkrehi 5344 19 % % NN cord-335975-m6lkrehi 5344 20 ) ) -RRB- cord-335975-m6lkrehi 5344 21 followed follow VBN cord-335975-m6lkrehi 5344 22 by by IN cord-335975-m6lkrehi 5344 23 acintobacter acintobacter JJ cord-335975-m6lkrehi 5344 24 baumanii baumanii NNP cord-335975-m6lkrehi 5344 25 ( ( -LRB- cord-335975-m6lkrehi 5344 26 8 8 CD cord-335975-m6lkrehi 5344 27 % % NN cord-335975-m6lkrehi 5344 28 ) ) -RRB- cord-335975-m6lkrehi 5344 29 enterobacteries enterobacterie NNS cord-335975-m6lkrehi 5344 30 representing represent VBG cord-335975-m6lkrehi 5344 31 the the DT cord-335975-m6lkrehi 5344 32 rest.12 rest.12 NNP cord-335975-m6lkrehi 5344 33 % % NN cord-335975-m6lkrehi 5344 34 lung lung NN cord-335975-m6lkrehi 5344 35 infection infection NN cord-335975-m6lkrehi 5344 36 with with IN cord-335975-m6lkrehi 5344 37 Gram gram NN cord-335975-m6lkrehi 5344 38 - - HYPH cord-335975-m6lkrehi 5344 39 positive positive JJ cord-335975-m6lkrehi 5344 40 cocci coccus NNS cord-335975-m6lkrehi 5344 41 ( ( -LRB- cord-335975-m6lkrehi 5344 42 principally principally RB cord-335975-m6lkrehi 5344 43 sensitive sensitive JJ cord-335975-m6lkrehi 5344 44 methicillin methicillin NNS cord-335975-m6lkrehi 5344 45 ) ) -RRB- cord-335975-m6lkrehi 5344 46 pseudomonas pseudomonas NNP cord-335975-m6lkrehi 5344 47 was be VBD cord-335975-m6lkrehi 5344 48 imipenem imipenem NN cord-335975-m6lkrehi 5344 49 resistant resistant JJ cord-335975-m6lkrehi 5344 50 in in IN cord-335975-m6lkrehi 5344 51 18.4 18.4 CD cord-335975-m6lkrehi 5344 52 % % NN cord-335975-m6lkrehi 5344 53 , , , cord-335975-m6lkrehi 5344 54 baumanii baumanii NNP cord-335975-m6lkrehi 5344 55 was be VBD cord-335975-m6lkrehi 5344 56 imipenem imipenem JJ cord-335975-m6lkrehi 5344 57 resistant resistant JJ cord-335975-m6lkrehi 5344 58 in in IN cord-335975-m6lkrehi 5344 59 55 55 CD cord-335975-m6lkrehi 5344 60 % % NN cord-335975-m6lkrehi 5344 61 . . . cord-335975-m6lkrehi 5345 1 The the DT cord-335975-m6lkrehi 5345 2 resistance resistance NN cord-335975-m6lkrehi 5345 3 profile profile NN cord-335975-m6lkrehi 5345 4 of of IN cord-335975-m6lkrehi 5345 5 the the DT cord-335975-m6lkrehi 5345 6 recovered recover VBN cord-335975-m6lkrehi 5345 7 germs germ NNS cord-335975-m6lkrehi 5345 8 ( ( -LRB- cord-335975-m6lkrehi 5345 9 baumanii baumanii NNP cord-335975-m6lkrehi 5345 10 and and CC cord-335975-m6lkrehi 5345 11 pseudomonas pseudomonas NNP cord-335975-m6lkrehi 5345 12 ) ) -RRB- cord-335975-m6lkrehi 5345 13 encourages encourage VBZ cord-335975-m6lkrehi 5345 14 the the DT cord-335975-m6lkrehi 5345 15 utmost utmost JJ cord-335975-m6lkrehi 5345 16 rigor rigor NN cord-335975-m6lkrehi 5345 17 in in IN cord-335975-m6lkrehi 5345 18 the the DT cord-335975-m6lkrehi 5345 19 management management NN cord-335975-m6lkrehi 5345 20 of of IN cord-335975-m6lkrehi 5345 21 these these DT cord-335975-m6lkrehi 5345 22 patients patient NNS cord-335975-m6lkrehi 5345 23 , , , cord-335975-m6lkrehi 5345 24 prevention prevention NN cord-335975-m6lkrehi 5345 25 is be VBZ cord-335975-m6lkrehi 5345 26 better well JJR cord-335975-m6lkrehi 5345 27 attitude attitude NN cord-335975-m6lkrehi 5345 28 to to TO cord-335975-m6lkrehi 5345 29 adopt adopt VB cord-335975-m6lkrehi 5345 30 . . . cord-335975-m6lkrehi 5346 1 Introduction introduction NN cord-335975-m6lkrehi 5346 2 : : : cord-335975-m6lkrehi 5347 1 The the DT cord-335975-m6lkrehi 5347 2 ventilator ventilator NN cord-335975-m6lkrehi 5347 3 associated associate VBD cord-335975-m6lkrehi 5347 4 pneumonia pneumonia NN cord-335975-m6lkrehi 5347 5 ( ( -LRB- cord-335975-m6lkrehi 5347 6 VAP VAP NNP cord-335975-m6lkrehi 5347 7 ) ) -RRB- cord-335975-m6lkrehi 5347 8 appear appear VBP cord-335975-m6lkrehi 5347 9 in in IN cord-335975-m6lkrehi 5347 10 the the DT cord-335975-m6lkrehi 5347 11 second second JJ cord-335975-m6lkrehi 5347 12 rank rank NN cord-335975-m6lkrehi 5347 13 of of IN cord-335975-m6lkrehi 5347 14 the the DT cord-335975-m6lkrehi 5347 15 infections infection NNS cord-335975-m6lkrehi 5347 16 acquired acquire VBN cord-335975-m6lkrehi 5347 17 in in IN cord-335975-m6lkrehi 5347 18 hospital hospital NN cord-335975-m6lkrehi 5347 19 after after IN cord-335975-m6lkrehi 5347 20 the the DT cord-335975-m6lkrehi 5347 21 urinary urinary JJ cord-335975-m6lkrehi 5347 22 infections infection NNS cord-335975-m6lkrehi 5347 23 . . . cord-335975-m6lkrehi 5348 1 The the DT cord-335975-m6lkrehi 5348 2 diagnosis diagnosis NN cord-335975-m6lkrehi 5348 3 is be VBZ cord-335975-m6lkrehi 5348 4 based base VBN cord-335975-m6lkrehi 5348 5 on on IN cord-335975-m6lkrehi 5348 6 a a DT cord-335975-m6lkrehi 5348 7 beam beam NN cord-335975-m6lkrehi 5348 8 of of IN cord-335975-m6lkrehi 5348 9 clinical clinical JJ cord-335975-m6lkrehi 5348 10 , , , cord-335975-m6lkrehi 5348 11 biological biological JJ cord-335975-m6lkrehi 5348 12 , , , cord-335975-m6lkrehi 5348 13 radiological radiological JJ cord-335975-m6lkrehi 5348 14 and and CC cord-335975-m6lkrehi 5348 15 bacteriological bacteriological JJ cord-335975-m6lkrehi 5348 16 arguments argument NNS cord-335975-m6lkrehi 5348 17 . . . cord-335975-m6lkrehi 5349 1 This this DT cord-335975-m6lkrehi 5349 2 work work NN cord-335975-m6lkrehi 5349 3 consisted consist VBD cord-335975-m6lkrehi 5349 4 of of IN cord-335975-m6lkrehi 5349 5 an an DT cord-335975-m6lkrehi 5349 6 epidemiologic epidemiologic JJ cord-335975-m6lkrehi 5349 7 analysis analysis NN cord-335975-m6lkrehi 5349 8 of of IN cord-335975-m6lkrehi 5349 9 the the DT cord-335975-m6lkrehi 5349 10 VAP VAP NNP cord-335975-m6lkrehi 5349 11 and and CC cord-335975-m6lkrehi 5349 12 aimed aim VBN cord-335975-m6lkrehi 5349 13 at at IN cord-335975-m6lkrehi 5349 14 evaluating evaluate VBG cord-335975-m6lkrehi 5349 15 of of IN cord-335975-m6lkrehi 5349 16 it -PRON- PRP cord-335975-m6lkrehi 5349 17 the the DT cord-335975-m6lkrehi 5349 18 frequency frequency NN cord-335975-m6lkrehi 5349 19 , , , cord-335975-m6lkrehi 5349 20 the the DT cord-335975-m6lkrehi 5349 21 risk risk NN cord-335975-m6lkrehi 5349 22 factors factor NNS cord-335975-m6lkrehi 5349 23 , , , cord-335975-m6lkrehi 5349 24 the the DT cord-335975-m6lkrehi 5349 25 antibioresistance antibioresistance NN cord-335975-m6lkrehi 5349 26 of of IN cord-335975-m6lkrehi 5349 27 the the DT cord-335975-m6lkrehi 5349 28 isolated isolate VBN cord-335975-m6lkrehi 5349 29 bacteria bacteria NNS cord-335975-m6lkrehi 5349 30 and and CC cord-335975-m6lkrehi 5349 31 the the DT cord-335975-m6lkrehi 5349 32 mortality mortality NN cord-335975-m6lkrehi 5349 33 factors factor NNS cord-335975-m6lkrehi 5349 34 . . . cord-335975-m6lkrehi 5350 1 Patients patient NNS cord-335975-m6lkrehi 5350 2 and and CC cord-335975-m6lkrehi 5350 3 methods method NNS cord-335975-m6lkrehi 5350 4 : : : cord-335975-m6lkrehi 5350 5 This this DT cord-335975-m6lkrehi 5350 6 retrospective retrospective JJ cord-335975-m6lkrehi 5350 7 study study NN cord-335975-m6lkrehi 5350 8 related relate VBN cord-335975-m6lkrehi 5350 9 to to IN cord-335975-m6lkrehi 5350 10 906 906 CD cord-335975-m6lkrehi 5350 11 patients patient NNS cord-335975-m6lkrehi 5350 12 hospitalized hospitalize VBN cord-335975-m6lkrehi 5350 13 in in IN cord-335975-m6lkrehi 5350 14 ICU ICU NNP cord-335975-m6lkrehi 5350 15 during during IN cord-335975-m6lkrehi 5350 16 a a DT cord-335975-m6lkrehi 5350 17 period period NN cord-335975-m6lkrehi 5350 18 of of IN cord-335975-m6lkrehi 5350 19 3 3 CD cord-335975-m6lkrehi 5350 20 years year NNS cord-335975-m6lkrehi 5350 21 from from IN cord-335975-m6lkrehi 5350 22 January January NNP cord-335975-m6lkrehi 5350 23 2014 2014 CD cord-335975-m6lkrehi 5350 24 to to IN cord-335975-m6lkrehi 5350 25 December December NNP cord-335975-m6lkrehi 5350 26 2016 2016 CD cord-335975-m6lkrehi 5350 27 . . . cord-335975-m6lkrehi 5351 1 The the DT cord-335975-m6lkrehi 5351 2 study study NN cord-335975-m6lkrehi 5351 3 included include VBD cord-335975-m6lkrehi 5351 4 all all DT cord-335975-m6lkrehi 5351 5 patients patient NNS cord-335975-m6lkrehi 5351 6 over over IN cord-335975-m6lkrehi 5351 7 18 18 CD cord-335975-m6lkrehi 5351 8 years year NNS cord-335975-m6lkrehi 5351 9 and and CC cord-335975-m6lkrehi 5351 10 ventilated ventilate VBD cord-335975-m6lkrehi 5351 11 more more JJR cord-335975-m6lkrehi 5351 12 than than IN cord-335975-m6lkrehi 5351 13 48 48 CD cord-335975-m6lkrehi 5351 14 h h NN cord-335975-m6lkrehi 5351 15 and and CC cord-335975-m6lkrehi 5351 16 developing develop VBG cord-335975-m6lkrehi 5351 17 VAP VAP NNP cord-335975-m6lkrehi 5351 18 . . . cord-335975-m6lkrehi 5352 1 Results result NNS cord-335975-m6lkrehi 5352 2 : : : cord-335975-m6lkrehi 5353 1 BGN bgn NN cord-335975-m6lkrehi 5353 2 predominant predominant NN cord-335975-m6lkrehi 5353 3 and and CC cord-335975-m6lkrehi 5353 4 represent represent VBP cord-335975-m6lkrehi 5353 5 80.16 80.16 CD cord-335975-m6lkrehi 5353 6 % % NN cord-335975-m6lkrehi 5353 7 of of IN cord-335975-m6lkrehi 5353 8 identified identify VBN cord-335975-m6lkrehi 5353 9 germs germ NNS cord-335975-m6lkrehi 5353 10 , , , cord-335975-m6lkrehi 5353 11 the the DT cord-335975-m6lkrehi 5353 12 Acinetobacter Acinetobacter NNP cord-335975-m6lkrehi 5353 13 baumanni baumanni NNP cord-335975-m6lkrehi 5353 14 leads lead VBZ cord-335975-m6lkrehi 5353 15 with with IN cord-335975-m6lkrehi 5353 16 33.88 33.88 CD cord-335975-m6lkrehi 5353 17 % % NN cord-335975-m6lkrehi 5353 18 , , , cord-335975-m6lkrehi 5353 19 followed follow VBN cord-335975-m6lkrehi 5353 20 by by IN cord-335975-m6lkrehi 5353 21 klebsiella klebsiella NNP cord-335975-m6lkrehi 5353 22 pneumonia pneumonia NNP cord-335975-m6lkrehi 5353 23 ( ( -LRB- cord-335975-m6lkrehi 5353 24 13.22 13.22 CD cord-335975-m6lkrehi 5353 25 % % NN cord-335975-m6lkrehi 5353 26 ) ) -RRB- cord-335975-m6lkrehi 5353 27 , , , cord-335975-m6lkrehi 5353 28 followed follow VBN cord-335975-m6lkrehi 5353 29 by by IN cord-335975-m6lkrehi 5353 30 Pseudomonas Pseudomonas NNP cord-335975-m6lkrehi 5353 31 aeruginosa aeruginosa NN cord-335975-m6lkrehi 5353 32 ( ( -LRB- cord-335975-m6lkrehi 5353 33 9.92 9.92 CD cord-335975-m6lkrehi 5353 34 % % NN cord-335975-m6lkrehi 5353 35 ) ) -RRB- cord-335975-m6lkrehi 5353 36 , , , cord-335975-m6lkrehi 5353 37 followed follow VBN cord-335975-m6lkrehi 5353 38 by by IN cord-335975-m6lkrehi 5353 39 E. E. NNP cord-335975-m6lkrehi 5353 40 coli coli NNS cord-335975-m6lkrehi 5353 41 ( ( -LRB- cord-335975-m6lkrehi 5353 42 6.61 6.61 CD cord-335975-m6lkrehi 5353 43 % % NN cord-335975-m6lkrehi 5353 44 ) ) -RRB- cord-335975-m6lkrehi 5353 45 , , , cord-335975-m6lkrehi 5353 46 followed follow VBN cord-335975-m6lkrehi 5353 47 by by IN cord-335975-m6lkrehi 5353 48 Enterobacter Enterobacter NNP cord-335975-m6lkrehi 5353 49 cloacae cloacae NN cord-335975-m6lkrehi 5353 50 ( ( -LRB- cord-335975-m6lkrehi 5353 51 3.31 3.31 CD cord-335975-m6lkrehi 5353 52 % % NN cord-335975-m6lkrehi 5353 53 ) ) -RRB- cord-335975-m6lkrehi 5353 54 and and CC cord-335975-m6lkrehi 5353 55 citrobacter citrobacter NNP cord-335975-m6lkrehi 5353 56 frendi frendi NNP cord-335975-m6lkrehi 5353 57 ( ( -LRB- cord-335975-m6lkrehi 5353 58 1.65 1.65 CD cord-335975-m6lkrehi 5353 59 % % NN cord-335975-m6lkrehi 5353 60 ) ) -RRB- cord-335975-m6lkrehi 5353 61 . . . cord-335975-m6lkrehi 5354 1 The the DT cord-335975-m6lkrehi 5354 2 cocci coccus NNS cord-335975-m6lkrehi 5354 3 gram gram NN cord-335975-m6lkrehi 5354 4 positive positive JJ cord-335975-m6lkrehi 5354 5 ( ( -LRB- cord-335975-m6lkrehi 5354 6 CGP CGP NNP cord-335975-m6lkrehi 5354 7 ) ) -RRB- cord-335975-m6lkrehi 5354 8 constitue constitue VBD cord-335975-m6lkrehi 5354 9 18.19 18.19 CD cord-335975-m6lkrehi 5354 10 % % NN cord-335975-m6lkrehi 5354 11 of of IN cord-335975-m6lkrehi 5354 12 isolated isolated JJ cord-335975-m6lkrehi 5354 13 germs germ NNS cord-335975-m6lkrehi 5354 14 of of IN cord-335975-m6lkrehi 5354 15 witch witch NN cord-335975-m6lkrehi 5354 16 14.88 14.88 CD cord-335975-m6lkrehi 5354 17 % % NN cord-335975-m6lkrehi 5354 18 Staphylococcus Staphylococcus NNP cord-335975-m6lkrehi 5354 19 aureus aureus NN cord-335975-m6lkrehi 5354 20 , , , cord-335975-m6lkrehi 5354 21 0.83 0.83 CD cord-335975-m6lkrehi 5354 22 % % NN cord-335975-m6lkrehi 5354 23 of of IN cord-335975-m6lkrehi 5354 24 non non JJ cord-335975-m6lkrehi 5354 25 aureus aureus NN cord-335975-m6lkrehi 5354 26 staphylococci staphylococcus NNS cord-335975-m6lkrehi 5354 27 , , , cord-335975-m6lkrehi 5354 28 2.48 2.48 CD cord-335975-m6lkrehi 5354 29 % % NN cord-335975-m6lkrehi 5354 30 Streptococcus streptococcus NN cord-335975-m6lkrehi 5354 31 sp sp NN cord-335975-m6lkrehi 5354 32 . . . cord-335975-m6lkrehi 5355 1 The the DT cord-335975-m6lkrehi 5355 2 polymicrobism polymicrobism NN cord-335975-m6lkrehi 5355 3 was be VBD cord-335975-m6lkrehi 5355 4 found find VBN cord-335975-m6lkrehi 5355 5 in in IN cord-335975-m6lkrehi 5355 6 33 33 CD cord-335975-m6lkrehi 5355 7 % % NN cord-335975-m6lkrehi 5355 8 cases case NNS cord-335975-m6lkrehi 5355 9 . . . cord-335975-m6lkrehi 5356 1 The the DT cord-335975-m6lkrehi 5356 2 isolated isolated JJ cord-335975-m6lkrehi 5356 3 germs germ NNS cord-335975-m6lkrehi 5356 4 were be VBD cord-335975-m6lkrehi 5356 5 multiresistants multiresistant NNS cord-335975-m6lkrehi 5356 6 . . . cord-335975-m6lkrehi 5357 1 In in IN cord-335975-m6lkrehi 5357 2 this this DT cord-335975-m6lkrehi 5357 3 study study NN cord-335975-m6lkrehi 5357 4 , , , cord-335975-m6lkrehi 5357 5 we -PRON- PRP cord-335975-m6lkrehi 5357 6 find find VBP cord-335975-m6lkrehi 5357 7 a a DT cord-335975-m6lkrehi 5357 8 very very RB cord-335975-m6lkrehi 5357 9 high high JJ cord-335975-m6lkrehi 5357 10 mortality mortality NN cord-335975-m6lkrehi 5357 11 and and CC cord-335975-m6lkrehi 5357 12 a a DT cord-335975-m6lkrehi 5357 13 major major JJ cord-335975-m6lkrehi 5357 14 additional additional JJ cord-335975-m6lkrehi 5357 15 morbidity morbidity NN cord-335975-m6lkrehi 5357 16 of of IN cord-335975-m6lkrehi 5357 17 the the DT cord-335975-m6lkrehi 5357 18 NP NP NNP cord-335975-m6lkrehi 5357 19 by by IN cord-335975-m6lkrehi 5357 20 prolongation prolongation NN cord-335975-m6lkrehi 5357 21 of of IN cord-335975-m6lkrehi 5357 22 hospitalization hospitalization NN cord-335975-m6lkrehi 5357 23 , , , cord-335975-m6lkrehi 5357 24 of of IN cord-335975-m6lkrehi 5357 25 mechanical mechanical JJ cord-335975-m6lkrehi 5357 26 ventilation ventilation NN cord-335975-m6lkrehi 5357 27 and and CC cord-335975-m6lkrehi 5357 28 a a DT cord-335975-m6lkrehi 5357 29 major major JJ cord-335975-m6lkrehi 5357 30 additional additional JJ cord-335975-m6lkrehi 5357 31 cost cost NN cord-335975-m6lkrehi 5357 32 . . . cord-335975-m6lkrehi 5358 1 Conclusion conclusion NN cord-335975-m6lkrehi 5358 2 : : : cord-335975-m6lkrehi 5359 1 It -PRON- PRP cord-335975-m6lkrehi 5359 2 appears appear VBZ cord-335975-m6lkrehi 5359 3 in in IN cord-335975-m6lkrehi 5359 4 the the DT cord-335975-m6lkrehi 5359 5 light light NN cord-335975-m6lkrehi 5359 6 of of IN cord-335975-m6lkrehi 5359 7 this this DT cord-335975-m6lkrehi 5359 8 work work NN cord-335975-m6lkrehi 5359 9 that that WDT cord-335975-m6lkrehi 5359 10 a a DT cord-335975-m6lkrehi 5359 11 strategy strategy NN cord-335975-m6lkrehi 5359 12 of of IN cord-335975-m6lkrehi 5359 13 prevention prevention NN cord-335975-m6lkrehi 5359 14 based base VBN cord-335975-m6lkrehi 5359 15 on on IN cord-335975-m6lkrehi 5359 16 the the DT cord-335975-m6lkrehi 5359 17 strict strict JJ cord-335975-m6lkrehi 5359 18 application application NN cord-335975-m6lkrehi 5359 19 of of IN cord-335975-m6lkrehi 5359 20 hygiene hygiene NN cord-335975-m6lkrehi 5359 21 measurements measurement NNS cord-335975-m6lkrehi 5359 22 , , , cord-335975-m6lkrehi 5359 23 the the DT cord-335975-m6lkrehi 5359 24 maintenance maintenance NN cord-335975-m6lkrehi 5359 25 of of IN cord-335975-m6lkrehi 5359 26 the the DT cord-335975-m6lkrehi 5359 27 material material NN cord-335975-m6lkrehi 5359 28 of of IN cord-335975-m6lkrehi 5359 29 ventilation ventilation NN cord-335975-m6lkrehi 5359 30 and and CC cord-335975-m6lkrehi 5359 31 the the DT cord-335975-m6lkrehi 5359 32 respect respect NN cord-335975-m6lkrehi 5359 33 of of IN cord-335975-m6lkrehi 5359 34 care care NN cord-335975-m6lkrehi 5359 35 procedures procedure NNS cord-335975-m6lkrehi 5359 36 prove prove VBP cord-335975-m6lkrehi 5359 37 to to TO cord-335975-m6lkrehi 5359 38 be be VB cord-335975-m6lkrehi 5359 39 urgent urgent JJ cord-335975-m6lkrehi 5359 40 in in IN cord-335975-m6lkrehi 5359 41 our -PRON- PRP$ cord-335975-m6lkrehi 5359 42 context context NN cord-335975-m6lkrehi 5359 43 . . . cord-335975-m6lkrehi 5360 1 Introduction introduction NN cord-335975-m6lkrehi 5360 2 : : : cord-335975-m6lkrehi 5360 3 Burns burn NNS cord-335975-m6lkrehi 5360 4 induce induce VB cord-335975-m6lkrehi 5360 5 modification modification NN cord-335975-m6lkrehi 5360 6 of of IN cord-335975-m6lkrehi 5360 7 distribution distribution NN cord-335975-m6lkrehi 5360 8 volume volume NN cord-335975-m6lkrehi 5360 9 , , , cord-335975-m6lkrehi 5360 10 increased increase VBN cord-335975-m6lkrehi 5360 11 clearance clearance NN cord-335975-m6lkrehi 5360 12 of of IN cord-335975-m6lkrehi 5360 13 drugs drug NNS cord-335975-m6lkrehi 5360 14 and and CC cord-335975-m6lkrehi 5360 15 decrease decrease NN cord-335975-m6lkrehi 5360 16 of of IN cord-335975-m6lkrehi 5360 17 protein protein NN cord-335975-m6lkrehi 5360 18 binding binding NN cord-335975-m6lkrehi 5360 19 . . . cord-335975-m6lkrehi 5361 1 Amikacin Amikacin NNP cord-335975-m6lkrehi 5361 2 pharmacokinetics pharmacokinetic NNS cord-335975-m6lkrehi 5361 3 ( ( -LRB- cord-335975-m6lkrehi 5361 4 PK PK NNP cord-335975-m6lkrehi 5361 5 ) ) -RRB- cord-335975-m6lkrehi 5361 6 was be VBD cord-335975-m6lkrehi 5361 7 altered alter VBN cord-335975-m6lkrehi 5361 8 with with IN cord-335975-m6lkrehi 5361 9 subthera subthera NN cord-335975-m6lkrehi 5361 10 - - HYPH cord-335975-m6lkrehi 5361 11 peutic peutic JJ cord-335975-m6lkrehi 5361 12 serum serum NN cord-335975-m6lkrehi 5361 13 concentrations concentration NNS cord-335975-m6lkrehi 5361 14 . . . cord-335975-m6lkrehi 5362 1 The the DT cord-335975-m6lkrehi 5362 2 aim aim NN cord-335975-m6lkrehi 5362 3 of of IN cord-335975-m6lkrehi 5362 4 our -PRON- PRP$ cord-335975-m6lkrehi 5362 5 study study NN cord-335975-m6lkrehi 5362 6 was be VBD cord-335975-m6lkrehi 5362 7 to to TO cord-335975-m6lkrehi 5362 8 assess assess VB cord-335975-m6lkrehi 5362 9 the the DT cord-335975-m6lkrehi 5362 10 PK PK NNP cord-335975-m6lkrehi 5362 11 of of IN cord-335975-m6lkrehi 5362 12 amikacin amikacin NNS cord-335975-m6lkrehi 5362 13 in in IN cord-335975-m6lkrehi 5362 14 burns burn NNS cord-335975-m6lkrehi 5362 15 after after IN cord-335975-m6lkrehi 5362 16 a a DT cord-335975-m6lkrehi 5362 17 loading loading NN cord-335975-m6lkrehi 5362 18 dose dose NN cord-335975-m6lkrehi 5362 19 given give VBN cord-335975-m6lkrehi 5362 20 once once RB cord-335975-m6lkrehi 5362 21 a a DT cord-335975-m6lkrehi 5362 22 day day NN cord-335975-m6lkrehi 5362 23 according accord VBG cord-335975-m6lkrehi 5362 24 to to IN cord-335975-m6lkrehi 5362 25 this this DT cord-335975-m6lkrehi 5362 26 equation equation NN cord-335975-m6lkrehi 5362 27 - - HYPH cord-335975-m6lkrehi 5362 28 Dose(mg Dose(mg NNP cord-335975-m6lkrehi 5362 29 kg kg NNP cord-335975-m6lkrehi 5362 30 ) ) -RRB- cord-335975-m6lkrehi 5362 31 = = NFP cord-335975-m6lkrehi 5363 1 30*Pi(30 30*pi(30 LS cord-335975-m6lkrehi 5363 2 * * NFP cord-335975-m6lkrehi 5363 3 0,4*Dp1 0,4*dp1 CD cord-335975-m6lkrehi 5363 4 ) ) -RRB- cord-335975-m6lkrehi 5364 1 + + JJ cord-335975-m6lkrehi 5364 2 ( ( -LRB- cord-335975-m6lkrehi 5364 3 30 30 CD cord-335975-m6lkrehi 5364 4 * * NFP cord-335975-m6lkrehi 5364 5 0,4 0,4 XX cord-335975-m6lkrehi 5365 1 * * NFP cord-335975-m6lkrehi 5365 2 Dp2 Dp2 NNP cord-335975-m6lkrehi 5365 3 ) ) -RRB- cord-335975-m6lkrehi 5365 4 . . . cord-335975-m6lkrehi 5366 1 Threshold threshold NN cord-335975-m6lkrehi 5366 2 for for IN cord-335975-m6lkrehi 5366 3 therapeutic therapeutic JJ cord-335975-m6lkrehi 5366 4 efficacy efficacy NN cord-335975-m6lkrehi 5366 5 was be VBD cord-335975-m6lkrehi 5366 6 a a DT cord-335975-m6lkrehi 5366 7 ratio ratio NN cord-335975-m6lkrehi 5366 8 of of IN cord-335975-m6lkrehi 5366 9 ≥ ≥ CD cord-335975-m6lkrehi 5366 10 8 8 CD cord-335975-m6lkrehi 5366 11 between between IN cord-335975-m6lkrehi 5366 12 the the DT cord-335975-m6lkrehi 5366 13 concentration concentration NN cord-335975-m6lkrehi 5366 14 achieved achieve VBD cord-335975-m6lkrehi 5366 15 1 1 CD cord-335975-m6lkrehi 5366 16 h h NN cord-335975-m6lkrehi 5366 17 after after IN cord-335975-m6lkrehi 5366 18 beginning begin VBG cord-335975-m6lkrehi 5366 19 the the DT cord-335975-m6lkrehi 5366 20 infusion infusion NN cord-335975-m6lkrehi 5366 21 ( ( -LRB- cord-335975-m6lkrehi 5366 22 C C NNP cord-335975-m6lkrehi 5366 23 peak peak NN cord-335975-m6lkrehi 5366 24 ) ) -RRB- cord-335975-m6lkrehi 5366 25 and and CC cord-335975-m6lkrehi 5366 26 the the DT cord-335975-m6lkrehi 5366 27 minimal minimal JJ cord-335975-m6lkrehi 5366 28 inhibitory inhibitory JJ cord-335975-m6lkrehi 5366 29 concentration concentration NN cord-335975-m6lkrehi 5366 30 ( ( -LRB- cord-335975-m6lkrehi 5366 31 MIC MIC NNP cord-335975-m6lkrehi 5366 32 ) ) -RRB- cord-335975-m6lkrehi 5366 33 of of IN cord-335975-m6lkrehi 5366 34 the the DT cord-335975-m6lkrehi 5366 35 isolated isolated JJ cord-335975-m6lkrehi 5366 36 pathogen pathogen NN cord-335975-m6lkrehi 5366 37 . . . cord-335975-m6lkrehi 5367 1 Patients patient NNS cord-335975-m6lkrehi 5367 2 and and CC cord-335975-m6lkrehi 5367 3 methods method NNS cord-335975-m6lkrehi 5367 4 : : : cord-335975-m6lkrehi 5367 5 This this DT cord-335975-m6lkrehi 5367 6 study study NN cord-335975-m6lkrehi 5367 7 was be VBD cord-335975-m6lkrehi 5367 8 conducted conduct VBN cord-335975-m6lkrehi 5367 9 in in IN cord-335975-m6lkrehi 5367 10 burn burn NN cord-335975-m6lkrehi 5367 11 center center NN cord-335975-m6lkrehi 5367 12 in in IN cord-335975-m6lkrehi 5367 13 Tunis Tunis NNP cord-335975-m6lkrehi 5367 14 . . . cord-335975-m6lkrehi 5368 1 Patients patient NNS cord-335975-m6lkrehi 5368 2 with with IN cord-335975-m6lkrehi 5368 3 documented document VBN cord-335975-m6lkrehi 5368 4 and and CC cord-335975-m6lkrehi 5368 5 or or CC cord-335975-m6lkrehi 5368 6 suspected suspect VBN cord-335975-m6lkrehi 5368 7 infections infection NNS cord-335975-m6lkrehi 5368 8 were be VBD cord-335975-m6lkrehi 5368 9 included include VBN cord-335975-m6lkrehi 5368 10 . . . cord-335975-m6lkrehi 5369 1 Were be VBD cord-335975-m6lkrehi 5369 2 excluded exclude VBN cord-335975-m6lkrehi 5369 3 pregnant pregnant JJ cord-335975-m6lkrehi 5369 4 women woman NNS cord-335975-m6lkrehi 5369 5 and and CC cord-335975-m6lkrehi 5369 6 patients patient NNS cord-335975-m6lkrehi 5369 7 with with IN cord-335975-m6lkrehi 5369 8 renal renal JJ cord-335975-m6lkrehi 5369 9 failure failure NN cord-335975-m6lkrehi 5369 10 . . . cord-335975-m6lkrehi 5370 1 Enrolled enrol VBN cord-335975-m6lkrehi 5370 2 patients patient NNS cord-335975-m6lkrehi 5370 3 received receive VBD cord-335975-m6lkrehi 5370 4 amikacin amikacin NNS cord-335975-m6lkrehi 5370 5 at at IN cord-335975-m6lkrehi 5370 6 a a DT cord-335975-m6lkrehi 5370 7 loading loading NN cord-335975-m6lkrehi 5370 8 dose dose NN cord-335975-m6lkrehi 5370 9 in in IN cord-335975-m6lkrehi 5370 10 1 1 CD cord-335975-m6lkrehi 5370 11 h h NN cord-335975-m6lkrehi 5370 12 infusion infusion NN cord-335975-m6lkrehi 5370 13 . . . cord-335975-m6lkrehi 5371 1 Blood blood NN cord-335975-m6lkrehi 5371 2 samples sample NNS cord-335975-m6lkrehi 5371 3 for for IN cord-335975-m6lkrehi 5371 4 PK PK NNP cord-335975-m6lkrehi 5371 5 analysis analysis NN cord-335975-m6lkrehi 5371 6 were be VBD cord-335975-m6lkrehi 5371 7 assessed assess VBN cord-335975-m6lkrehi 5371 8 during during IN cord-335975-m6lkrehi 5371 9 5 5 CD cord-335975-m6lkrehi 5371 10 days day NNS cord-335975-m6lkrehi 5371 11 ( ( -LRB- cord-335975-m6lkrehi 5371 12 total total JJ cord-335975-m6lkrehi 5371 13 duration duration NN cord-335975-m6lkrehi 5371 14 of of IN cord-335975-m6lkrehi 5371 15 amikacin)-immediately amikacin)-immediately RB cord-335975-m6lkrehi 5371 16 after after IN cord-335975-m6lkrehi 5371 17 the the DT cord-335975-m6lkrehi 5371 18 end end NN cord-335975-m6lkrehi 5371 19 of of IN cord-335975-m6lkrehi 5371 20 the the DT cord-335975-m6lkrehi 5371 21 first first JJ cord-335975-m6lkrehi 5371 22 infusion infusion NN cord-335975-m6lkrehi 5371 23 ( ( -LRB- cord-335975-m6lkrehi 5371 24 T1 T1 NNP cord-335975-m6lkrehi 5371 25 ) ) -RRB- cord-335975-m6lkrehi 5371 26 and and CC cord-335975-m6lkrehi 5371 27 30 30 CD cord-335975-m6lkrehi 5371 28 min min NN cord-335975-m6lkrehi 5371 29 after after IN cord-335975-m6lkrehi 5371 30 ( ( -LRB- cord-335975-m6lkrehi 5371 31 T2 T2 NNP cord-335975-m6lkrehi 5371 32 ) ) -RRB- cord-335975-m6lkrehi 5371 33 at at IN cord-335975-m6lkrehi 5371 34 day day NN cord-335975-m6lkrehi 5371 35 1 1 CD cord-335975-m6lkrehi 5371 36 . . . cord-335975-m6lkrehi 5372 1 For for IN cord-335975-m6lkrehi 5372 2 the the DT cord-335975-m6lkrehi 5372 3 2nd 2nd JJ cord-335975-m6lkrehi 5372 4 , , , cord-335975-m6lkrehi 5372 5 3rd 3rd JJ cord-335975-m6lkrehi 5372 6 , , , cord-335975-m6lkrehi 5372 7 4th 4th JJ cord-335975-m6lkrehi 5372 8 and and CC cord-335975-m6lkrehi 5372 9 5th 5th JJ cord-335975-m6lkrehi 5372 10 day day NN cord-335975-m6lkrehi 5372 11 , , , cord-335975-m6lkrehi 5372 12 blood blood NN cord-335975-m6lkrehi 5372 13 samples sample NNS cord-335975-m6lkrehi 5372 14 were be VBD cord-335975-m6lkrehi 5372 15 taken take VBN cord-335975-m6lkrehi 5372 16 before before IN cord-335975-m6lkrehi 5372 17 the the DT cord-335975-m6lkrehi 5372 18 infusion infusion NN cord-335975-m6lkrehi 5372 19 ( ( -LRB- cord-335975-m6lkrehi 5372 20 T0 T0 NNP cord-335975-m6lkrehi 5372 21 ) ) -RRB- cord-335975-m6lkrehi 5372 22 , , , cord-335975-m6lkrehi 5372 23 at at IN cord-335975-m6lkrehi 5372 24 the the DT cord-335975-m6lkrehi 5372 25 end end NN cord-335975-m6lkrehi 5372 26 ( ( -LRB- cord-335975-m6lkrehi 5372 27 T1 t1 NN cord-335975-m6lkrehi 5372 28 ) ) -RRB- cord-335975-m6lkrehi 5372 29 and and CC cord-335975-m6lkrehi 5372 30 30 30 CD cord-335975-m6lkrehi 5372 31 min min NN cord-335975-m6lkrehi 5372 32 after after IN cord-335975-m6lkrehi 5372 33 the the DT cord-335975-m6lkrehi 5372 34 end end NN cord-335975-m6lkrehi 5372 35 of of IN cord-335975-m6lkrehi 5372 36 it -PRON- PRP cord-335975-m6lkrehi 5372 37 ( ( -LRB- cord-335975-m6lkrehi 5372 38 T2 T2 NNP cord-335975-m6lkrehi 5372 39 ) ) -RRB- cord-335975-m6lkrehi 5372 40 . . . cord-335975-m6lkrehi 5373 1 Results result NNS cord-335975-m6lkrehi 5373 2 : : : cord-335975-m6lkrehi 5374 1 18 18 CD cord-335975-m6lkrehi 5374 2 burned burn VBN cord-335975-m6lkrehi 5374 3 patients patient NNS cord-335975-m6lkrehi 5374 4 were be VBD cord-335975-m6lkrehi 5374 5 included include VBN cord-335975-m6lkrehi 5374 6 . . . cord-335975-m6lkrehi 5375 1 The the DT cord-335975-m6lkrehi 5375 2 mean mean JJ cord-335975-m6lkrehi 5375 3 age age NN cord-335975-m6lkrehi 5375 4 was be VBD cord-335975-m6lkrehi 5375 5 40 40 CD cord-335975-m6lkrehi 5375 6 ± ± CD cord-335975-m6lkrehi 5375 7 15 15 CD cord-335975-m6lkrehi 5375 8 years year NNS cord-335975-m6lkrehi 5375 9 with with IN cord-335975-m6lkrehi 5375 10 a a DT cord-335975-m6lkrehi 5375 11 body body NN cord-335975-m6lkrehi 5375 12 weight weight NN cord-335975-m6lkrehi 5375 13 of of IN cord-335975-m6lkrehi 5375 14 78 78 CD cord-335975-m6lkrehi 5375 15 ± ± NNP cord-335975-m6lkrehi 5375 16 15 15 CD cord-335975-m6lkrehi 5375 17 kg kg NNS cord-335975-m6lkrehi 5375 18 . . . cord-335975-m6lkrehi 5376 1 The the DT cord-335975-m6lkrehi 5376 2 mean mean JJ cord-335975-m6lkrehi 5376 3 dose dose NN cord-335975-m6lkrehi 5376 4 of of IN cord-335975-m6lkrehi 5376 5 amikacin amikacin NN cord-335975-m6lkrehi 5376 6 was be VBD cord-335975-m6lkrehi 5376 7 26 26 CD cord-335975-m6lkrehi 5376 8 mg mg NNP cord-335975-m6lkrehi 5376 9 kg kg NNP cord-335975-m6lkrehi 5376 10 day day NN cord-335975-m6lkrehi 5376 11 [ [ -LRB- cord-335975-m6lkrehi 5376 12 20 20 CD cord-335975-m6lkrehi 5376 13 - - SYM cord-335975-m6lkrehi 5376 14 35 35 CD cord-335975-m6lkrehi 5377 1 mg mg NNP cord-335975-m6lkrehi 5377 2 kg kg NNP cord-335975-m6lkrehi 5377 3 day day NN cord-335975-m6lkrehi 5377 4 ] ] -RRB- cord-335975-m6lkrehi 5377 5 . . . cord-335975-m6lkrehi 5378 1 A a DT cord-335975-m6lkrehi 5378 2 peak peak NN cord-335975-m6lkrehi 5378 3 between between IN cord-335975-m6lkrehi 5378 4 60 60 CD cord-335975-m6lkrehi 5378 5 and and CC cord-335975-m6lkrehi 5378 6 80 80 CD cord-335975-m6lkrehi 5378 7 μg μg NNS cord-335975-m6lkrehi 5378 8 / / SYM cord-335975-m6lkrehi 5378 9 ml ml NN cord-335975-m6lkrehi 5378 10 was be VBD cord-335975-m6lkrehi 5378 11 reached reach VBN cord-335975-m6lkrehi 5378 12 in in IN cord-335975-m6lkrehi 5378 13 55 55 CD cord-335975-m6lkrehi 5378 14 % % NN cord-335975-m6lkrehi 5378 15 of of IN cord-335975-m6lkrehi 5378 16 cases case NNS cord-335975-m6lkrehi 5378 17 , , , cord-335975-m6lkrehi 5378 18 corresponding correspond VBG cord-335975-m6lkrehi 5378 19 to to IN cord-335975-m6lkrehi 5378 20 8 8 CD cord-335975-m6lkrehi 5378 21 times time NNS cord-335975-m6lkrehi 5378 22 the the DT cord-335975-m6lkrehi 5378 23 MIC MIC NNP cord-335975-m6lkrehi 5378 24 , , , cord-335975-m6lkrehi 5378 25 break break NN cord-335975-m6lkrehi 5378 26 - - HYPH cord-335975-m6lkrehi 5378 27 points point NNS cord-335975-m6lkrehi 5378 28 for for IN cord-335975-m6lkrehi 5378 29 Enterobactericeae Enterobactericeae NNP cord-335975-m6lkrehi 5378 30 and and CC cord-335975-m6lkrehi 5378 31 Pseudomonas Pseudomonas NNP cord-335975-m6lkrehi 5378 32 Aeuroginosa Aeuroginosa NNP cord-335975-m6lkrehi 5378 33 . . . cord-335975-m6lkrehi 5379 1 Total total JJ cord-335975-m6lkrehi 5379 2 volume volume NN cord-335975-m6lkrehi 5379 3 of of IN cord-335975-m6lkrehi 5379 4 distribution distribution NN cord-335975-m6lkrehi 5379 5 was be VBD cord-335975-m6lkrehi 5379 6 0.55 0.55 CD cord-335975-m6lkrehi 5379 7 L L NNP cord-335975-m6lkrehi 5379 8 kg kg NN cord-335975-m6lkrehi 5379 9 ( ( -LRB- cord-335975-m6lkrehi 5379 10 0.28 0.28 CD cord-335975-m6lkrehi 5379 11 - - SYM cord-335975-m6lkrehi 5379 12 1.32 1.32 CD cord-335975-m6lkrehi 5379 13 ) ) -RRB- cord-335975-m6lkrehi 5379 14 L L NNP cord-335975-m6lkrehi 5379 15 kg kg NNP cord-335975-m6lkrehi 5379 16 , , , cord-335975-m6lkrehi 5379 17 half half JJ cord-335975-m6lkrehi 5379 18 - - HYPH cord-335975-m6lkrehi 5379 19 life life NN cord-335975-m6lkrehi 5379 20 time time NN cord-335975-m6lkrehi 5379 21 ( ( -LRB- cord-335975-m6lkrehi 5379 22 t1 t1 NNP cord-335975-m6lkrehi 5379 23 2 2 CD cord-335975-m6lkrehi 5379 24 ) ) -RRB- cord-335975-m6lkrehi 5379 25 was be VBD cord-335975-m6lkrehi 5379 26 4.70 4.70 CD cord-335975-m6lkrehi 5379 27 h h XX cord-335975-m6lkrehi 5379 28 [ [ -LRB- cord-335975-m6lkrehi 5379 29 1.42 1.42 CD cord-335975-m6lkrehi 5379 30 - - SYM cord-335975-m6lkrehi 5379 31 8 8 CD cord-335975-m6lkrehi 5379 32 h h NN cord-335975-m6lkrehi 5379 33 ] ] -RRB- cord-335975-m6lkrehi 5379 34 and and CC cord-335975-m6lkrehi 5379 35 the the DT cord-335975-m6lkrehi 5379 36 amikacin amikacin NNP cord-335975-m6lkrehi 5379 37 clearance clearance NN cord-335975-m6lkrehi 5379 38 was be VBD cord-335975-m6lkrehi 5379 39 6.4 6.4 CD cord-335975-m6lkrehi 5379 40 L l NN cord-335975-m6lkrehi 5379 41 h. h. NN cord-335975-m6lkrehi 5380 1 A a DT cord-335975-m6lkrehi 5380 2 correlation correlation NN cord-335975-m6lkrehi 5380 3 was be VBD cord-335975-m6lkrehi 5380 4 found find VBN cord-335975-m6lkrehi 5380 5 between between IN cord-335975-m6lkrehi 5380 6 Cpeak Cpeak NNP cord-335975-m6lkrehi 5381 1 At at IN cord-335975-m6lkrehi 5381 2 day day NN cord-335975-m6lkrehi 5381 3 1 1 CD cord-335975-m6lkrehi 5381 4 and and CC cord-335975-m6lkrehi 5381 5 Cpeak Cpeak NNP cord-335975-m6lkrehi 5381 6 at at IN cord-335975-m6lkrehi 5381 7 day day NN cord-335975-m6lkrehi 5381 8 5 5 CD cord-335975-m6lkrehi 5382 1 ( ( -LRB- cord-335975-m6lkrehi 5382 2 r r NN cord-335975-m6lkrehi 5382 3 = = SYM cord-335975-m6lkrehi 5382 4 0.45 0.45 CD cord-335975-m6lkrehi 5382 5 ) ) -RRB- cord-335975-m6lkrehi 5382 6 . . . cord-335975-m6lkrehi 5383 1 Conclusion conclusion NN cord-335975-m6lkrehi 5383 2 : : : cord-335975-m6lkrehi 5384 1 Our -PRON- PRP$ cord-335975-m6lkrehi 5384 2 study study NN cord-335975-m6lkrehi 5384 3 shows show VBZ cord-335975-m6lkrehi 5384 4 that that IN cord-335975-m6lkrehi 5384 5 an an DT cord-335975-m6lkrehi 5384 6 early early JJ cord-335975-m6lkrehi 5384 7 achievement achievement NN cord-335975-m6lkrehi 5384 8 of of IN cord-335975-m6lkrehi 5384 9 an an DT cord-335975-m6lkrehi 5384 10 optimal optimal JJ cord-335975-m6lkrehi 5384 11 Cpeak Cpeak NNP cord-335975-m6lkrehi 5384 12 MIC MIC NNP cord-335975-m6lkrehi 5384 13 ratio ratio NN cord-335975-m6lkrehi 5384 14 of of IN cord-335975-m6lkrehi 5384 15 amikacin amikacin NN cord-335975-m6lkrehi 5384 16 was be VBD cord-335975-m6lkrehi 5384 17 reached reach VBN cord-335975-m6lkrehi 5384 18 in in IN cord-335975-m6lkrehi 5384 19 half half NN cord-335975-m6lkrehi 5384 20 of of IN cord-335975-m6lkrehi 5384 21 cases case NNS cord-335975-m6lkrehi 5384 22 with with IN cord-335975-m6lkrehi 5384 23 a a DT cord-335975-m6lkrehi 5384 24 correlation correlation NN cord-335975-m6lkrehi 5384 25 between between IN cord-335975-m6lkrehi 5384 26 Cpeak Cpeak NNP cord-335975-m6lkrehi 5384 27 in in IN cord-335975-m6lkrehi 5384 28 the the DT cord-335975-m6lkrehi 5384 29 beginning beginning NN cord-335975-m6lkrehi 5384 30 and and CC cord-335975-m6lkrehi 5384 31 at at IN cord-335975-m6lkrehi 5384 32 the the DT cord-335975-m6lkrehi 5384 33 end end NN cord-335975-m6lkrehi 5384 34 of of IN cord-335975-m6lkrehi 5384 35 treatment treatment NN cord-335975-m6lkrehi 5384 36 . . . cord-335975-m6lkrehi 5385 1 So so RB cord-335975-m6lkrehi 5385 2 , , , cord-335975-m6lkrehi 5385 3 initial initial JJ cord-335975-m6lkrehi 5385 4 Cpeak Cpeak NNP cord-335975-m6lkrehi 5385 5 was be VBD cord-335975-m6lkrehi 5385 6 useful useful JJ cord-335975-m6lkrehi 5385 7 tu tu NNP cord-335975-m6lkrehi 5385 8 adjuste adjuste NNP cord-335975-m6lkrehi 5385 9 AMK AMK NNP cord-335975-m6lkrehi 5385 10 therapy therapy NN cord-335975-m6lkrehi 5385 11 in in IN cord-335975-m6lkrehi 5385 12 burns burn NNS cord-335975-m6lkrehi 5385 13 and and CC cord-335975-m6lkrehi 5385 14 predicts predict VBZ cord-335975-m6lkrehi 5385 15 treatment treatment NN cord-335975-m6lkrehi 5385 16 efficacy efficacy NN cord-335975-m6lkrehi 5385 17 . . . cord-335975-m6lkrehi 5386 1 * * NFP cord-335975-m6lkrehi 5386 2 Pi pi NN cord-335975-m6lkrehi 5386 3 - - HYPH cord-335975-m6lkrehi 5386 4 ideal ideal JJ cord-335975-m6lkrehi 5386 5 weight weight NN cord-335975-m6lkrehi 5386 6 + + CC cord-335975-m6lkrehi 5386 7 Dp1-admission dp1-admission NN cord-335975-m6lkrehi 5386 8 weight weight NN cord-335975-m6lkrehi 5386 9 - - HYPH cord-335975-m6lkrehi 5386 10 ideal ideal JJ cord-335975-m6lkrehi 5386 11 weight weight NN cord-335975-m6lkrehi 5386 12 + + CC cord-335975-m6lkrehi 5386 13 Dp2-actuel Dp2-actuel NNP cord-335975-m6lkrehi 5386 14 weight weight NN cord-335975-m6lkrehi 5386 15 - - HYPH cord-335975-m6lkrehi 5386 16 admission admission NN cord-335975-m6lkrehi 5386 17 weight weight NN cord-335975-m6lkrehi 5386 18 . . . cord-335975-m6lkrehi 5387 1 Publisher publisher NN cord-335975-m6lkrehi 5387 2 's 's POS cord-335975-m6lkrehi 5387 3 Note Note NNP cord-335975-m6lkrehi 5387 4 Springer Springer NNP cord-335975-m6lkrehi 5387 5 Nature Nature NNP cord-335975-m6lkrehi 5387 6 remains remain VBZ cord-335975-m6lkrehi 5387 7 neutral neutral JJ cord-335975-m6lkrehi 5387 8 with with IN cord-335975-m6lkrehi 5387 9 regard regard NN cord-335975-m6lkrehi 5387 10 to to IN cord-335975-m6lkrehi 5387 11 jurisdictional jurisdictional JJ cord-335975-m6lkrehi 5387 12 claims claim NNS cord-335975-m6lkrehi 5387 13 in in IN cord-335975-m6lkrehi 5387 14 published publish VBN cord-335975-m6lkrehi 5387 15 maps map NNS cord-335975-m6lkrehi 5387 16 and and CC cord-335975-m6lkrehi 5387 17 institutional institutional JJ cord-335975-m6lkrehi 5387 18 affiliations affiliation NNS cord-335975-m6lkrehi 5387 19 . . . cord-335975-m6lkrehi 5387 20 _SP