Carrel name: keyword-niv-cord Creating study carrel named keyword-niv-cord Initializing database parallel: Warning: No more processes: Decreasing number of running jobs to 50. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 49. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 48. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 47. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 46. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 45. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 44. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 43. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 42. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. file: cache/cord-029392-5s5686i9.json key: cord-029392-5s5686i9 authors: Zayed, Yazan; Kheiri, Babikir; Barbarawi, Mahmoud; Rashdan, Laith; Gakhal, Inderdeep; Ismail, Esra’a; Kerbage, Josiane; Rizk, Fatima; Shafi, Saadia; Bala, Areeg; Sidahmed, Shima; Bachuwa, Ghassan; Seedahmed, Elfateh title: Effect of oxygenation modalities among patients with postoperative respiratory failure: a pairwise and network meta-analysis of randomized controlled trials date: 2020-07-17 journal: J Intensive Care DOI: 10.1186/s40560-020-00468-x sha: doc_id: 29392 cord_uid: 5s5686i9 file: cache/cord-030131-klhg7x8z.json /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: Resource temporarily unavailable key: cord-030131-klhg7x8z authors: Tan, Dingyu; Walline, Joseph Harold; Ling, Bingyu; Xu, Yan; Sun, Jiayan; Wang, Bingxia; Shan, Xueqin; Wang, Yunyun; Cao, Peng; Zhu, Qingcheng; Geng, Ping; Xu, Jun title: High-flow nasal cannula oxygen therapy versus non-invasive ventilation for chronic obstructive pulmonary disease patients after extubation: a multicenter, randomized controlled trial date: 2020-08-06 journal: Crit Care DOI: 10.1186/s13054-020-03214-9 sha: doc_id: 30131 cord_uid: klhg7x8z file: cache/cord-000619-3bakci02.json /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes key: cord-000619-3bakci02 authors: Zhang, Peng-jun; Li, Xiao-li; Cao, Bin; Yang, Shi-gui; Liang, Li-rong; Gu, Li; Xu, Zhen; Hu, Ke; Zhang, Hong-yuan; Yan, Xi-xin; Huang, Wen-bao; Chen, Wei; Zhang, Jing-xiao; Li, Lan-juan; Wang, Chen title: Clinical features and risk factors for severe and critical pregnant women with 2009 pandemic H1N1 influenza infection in China date: 2012-02-01 journal: BMC Infect Dis DOI: 10.1186/1471-2334-12-29 sha: doc_id: 619 cord_uid: 3bakci02 file: cache/cord-000705-w52dc97h.json /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes key: cord-000705-w52dc97h authors: Ríos, Fernando G; Estenssoro, Elisa; Villarejo, Fernando; Valentini, Ricardo; Aguilar, Liliana; Pezzola, Daniel; Valdez, Pascual; Blasco, Miguel; Orlandi, Cristina; Alvarez, Javier; Saldarini, Fernando; Gómez, Alejandro; Gómez, Pablo E; Deheza, Martin; Zazu, Alan; Quinteros, Mónica; Chena, Ariel; Osatnik, Javier; Violi, Damian; Gonzalez, Maria Eugenia; Chiappero, Guillermo title: Lung Function and Organ Dysfunctions in 178 Patients Requiring Mechanical Ventilation During The 2009 Influenza A (H1N1) Pandemic date: 2011-08-17 journal: Crit Care DOI: 10.1186/cc10369 sha: doc_id: 705 cord_uid: w52dc97h file: cache/cord-002078-38rmx65j.json /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes key: cord-002078-38rmx65j authors: Korkmaz Ekren, Pervin; Basarik Aydogan, Burcu; Gurgun, Alev; Tasbakan, Mehmet Sezai; Bacakoglu, Feza; Nava, Stefano title: Can fiberoptic bronchoscopy be applied to critically ill patients treated with noninvasive ventilation for acute respiratory distress syndrome? Prospective observational study date: 2016-05-31 journal: BMC Pulm Med DOI: 10.1186/s12890-016-0236-y sha: doc_id: 2078 cord_uid: 38rmx65j file: cache/cord-009375-2hflah2h.json /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes key: cord-009375-2hflah2h authors: WANG, Xi-Jun; HU, Sen; GE, Jin-Ying; WANG, Qing-Hua; QIN, Li-Ting; BU, Zhi-Gao title: Study of Fusion Protein and Attachment Glycoprotein of Nipah Virus Expressed in Recombinant Baculovirus date: 2006-06-15 journal: nan DOI: 10.1016/s1872-2075(06)60038-1 sha: doc_id: 9375 cord_uid: 2hflah2h file: cache/cord-016042-iyuca9lv.json /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes key: cord-016042-iyuca9lv authors: Keymel, Stefanie; Steiner, Stephan title: Noninvasive Mechanical Ventilation Guidelines and Standard Protocols for Noninvasive Mechanical Ventilation in Patients with High-Risk Infections date: 2013-05-29 journal: Noninvasive Ventilation in High-Risk Infections and Mass Casualty Events DOI: 10.1007/978-3-7091-1496-4_40 sha: doc_id: 16042 cord_uid: iyuca9lv file: cache/cord-016416-h3cjylcl.json /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: Resource temporarily unavailable key: cord-016416-h3cjylcl authors: Javouhey, Etienne; Pouyau, Robin; Massenavette, Bruno title: Pathophysiology of Acute Respiratory Failure in Children with Bronchiolitis and Effect of CPAP date: 2013-05-29 journal: Noninvasive Ventilation in High-Risk Infections and Mass Casualty Events DOI: 10.1007/978-3-7091-1496-4_27 sha: doc_id: 16416 cord_uid: h3cjylcl parallel: Warning: No more processes: Decreasing number of running jobs to 41. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. file: cache/cord-011269-j2rogzm7.json /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes key: cord-011269-j2rogzm7 authors: Stefan, Mihaela S.; Pekow, Penelope S.; Shea, Christopher M.; Hughes, Ashley M.; Hill, Nicholas S.; Steingrub, Jay S.; Lindenauer, Peter K. title: Protocol for two-arm pragmatic cluster randomized hybrid implementation-effectiveness trial comparing two education strategies for improving the uptake of noninvasive ventilation in patients with severe COPD exacerbation date: 2020-05-06 journal: Implement Sci Commun DOI: 10.1186/s43058-020-00028-2 sha: doc_id: 11269 cord_uid: j2rogzm7 file: cache/cord-016744-jzhuq4te.json /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes key: cord-016744-jzhuq4te authors: Hui, David S. C. title: Noninvasive Mechanical Ventilation: Models to Assess Air and Particle Dispersion date: 2013-05-29 journal: Noninvasive Ventilation in High-Risk Infections and Mass Casualty Events DOI: 10.1007/978-3-7091-1496-4_2 sha: doc_id: 16744 cord_uid: jzhuq4te file: cache/cord-017240-2vqehqfh.json /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes key: cord-017240-2vqehqfh authors: Trindade e Silva, Luis Paulo; Gonçalves, Ana Paula; Lopes, Maria Luísa; de los Ángeles Zazo, Maria title: Noninvasive Mechanical Ventilation for Hypoxemic Respiratory Failure-Related Infectious Diseases date: 2013-05-29 journal: Noninvasive Ventilation in High-Risk Infections and Mass Casualty Events DOI: 10.1007/978-3-7091-1496-4_7 sha: doc_id: 17240 cord_uid: 2vqehqfh file: cache/cord-017282-rahtmu3h.json /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes key: cord-017282-rahtmu3h authors: Marvisi, Maurizio; Balzarini, Laura; Mancini, Chiara; Ramponi, Sara title: Pneumonia date: 2019-08-06 journal: Ventilatory Support and Oxygen Therapy in Elder, Palliative and End-of-Life Care Patients DOI: 10.1007/978-3-030-26664-6_12 sha: doc_id: 17282 cord_uid: rahtmu3h file: cache/cord-014538-6a2pviol.json /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes key: cord-014538-6a2pviol authors: Kamilia, Chtara; Regaieg, Kais; Baccouch, Najeh; Chelly, Hedi; Bahloul, Mabrouk; Bouaziz, Mounir; Jendoubi, Ali; Abbes, Ahmed; Belhaouane, Houda; Nasri, Oussama; Jenzri, Layla; Ghedira, Salma; Houissa, Mohamed; Belkadi, Kamal; Harti, Youness; Nsiri, Afak; Khaleq, Khalid; Hamoudi, Driss; Harrar, Rachid; Thieffry, Camille; Wallet, Frédéric; Parmentier-Decrucq, Erika; Favory, Raphaël; Mathieu, Daniel; Poissy, Julien; Lafon, Thomas; Vignon, Philippe; Begot, Emmanuelle; Appert, Alexandra; Hadj, Mathilde; Claverie, Paul; Matt, Morgan; Barraud, Olivier; François, Bruno; Jamoussi, Amira; Jazia, Amira Ben; Marhbène, Takoua; Lakhdhar, Dhouha; Khelil, Jalila Ben; Besbes, Mohamed; Goutay, Julien; Blazejewski, Caroline; Joly-Durand, Isabelle; Pirlet, Isabelle; Weillaert, Marie Pierre; Beague, Sebastien; Aziz, Soufi; Hafiane, Reda; Hattabi, Khalid; Bouhouri, Mohamed Aziz; Hammoudi, Driss; Fadil, Abdelaziz; Harrar, Rachid Al; Zerouali, Khalid; Medhioub, Fatma Kaaniche; Allela, Rania; Algia, Najla Ben; Cherif, Samar; Slaoui, Mohamed Taoufik; Boubia, Souhail; Hafiani, Y.; Khaoudi, A.; Cherkab, R.; Elallam, W.; Elkettani, C.; Barrou, L.; Ridaii, M.; Mehdi, Rihi El; Schimpf, Caroline; Mizrahi, Assaf; Pilmis, Benoît; Le Monnier, Alban; Tiercelet, Kelly; Cherin, Mélanie; Bruel, Cédric; Philippart, Francois; Bailly, Sébastien; Lucet, Jc; Lepape, Alain; L’hériteau, François; Aupée, Martine; Bervas, Caroline; Boussat, Sandrine; Berger-Carbonne, Anne; Machut, Anaïs; Savey, Anne; Timsit, Jean-François; Razazi, Keyvan; Rosman, Jérémy; de Prost, Nicolas; Carteaux, Guillaume; Jansen, Chloe; Decousser, Jean Winoc; Brun-Buisson, Christian; Dessap, Armand Mekontso; M’rad, Aymen; Ouali, Zouhour; Barghouth, Manel; Kouatchet, Achille; Mahieu, Rafael; Weiss, Emmanuel; Schnell, David; Zahar, Jean-Ralph; Artiguenave, Margaux; Sophie, Paktoris-Papine; Espinasse, Florence; Sayed, Faten El; Dinh, Aurélien; Charron, Cyril; Geri, Guillaume; Vieillard-Baron, Antoine; Repessé, Xavier; Kallel, Hatem; Mayence, Claire; Houcke, Stéphanie; Guegueniat, Pascal; Hommel, Didier; Dhifaoui, Kaouther; Hajjej, Zied; Fatnassi, Amira; Sellami, Walid; Labbene, Iheb; Ferjani, Mustapha; Dachraoui, Fahmi; Nakkaa, Sabrine; M’ghirbi, Abdelwaheb; Adhieb, Ali; Braiek, Dhouha Ben; Hraiech, Kmar; Ousji, Ali; Ouanes, Islem; Zaineb, Hammouda; Abdallah, Saousen Ben; Ouanes-Besbes, Lamia; Abroug, Fekri; Klein, Simon; Miquet, Mattéo; Thouret, Jean-Marc; Peigne, Vincent; Daban, Jean-Louis; Boutonnet, Mathieu; Lenoir, Bernard; Merhbene, Takoua; Derreumaux, Celine; Seguin, Thierry; Conil, Jean-Marie; Kelway, Charlotte; Blasco, Valery; Nafati, Cyril; Harti, Karim; Reydellet, Laurent; Albanese, Jacques; Aicha, Narjess Ben; Meddeb, Khaoula; Khedher, Ahmed; Ayachi, Jihene; Fraj, Nesrine; Sma, Nesrine; Chouchene, Imed; Boussarsar, Mohamed; Yedder, Soumaya Ben; Samoud, Walid; Radhouene, Bousselmi; Mariem, Bousselmi; Ammar, Asma; Cheikh, Asma Ben; Lakhal, Hend Ben; Khelfa, Messaouda; Hamdaoui, Yamina; Bouafia, Nabiha; Trampont, Timothée; Daix, Thomas; Legarçon, Vincent; Karam, Henri Hani; Pichon, Nicolas; Essafi, Fatma; Foudhaili, Nasreddine; Thabet, Hafedh; Blel, Youssef; Brahmi, Nozha; Ezzouine, Hanane; Kerrous, Mahmoud; Haoui, Saad El; Ahdil, Soufiane; Benslama, Abdellatif; Abidi, Khalid; Dendane, Tarek; Oussama, Ssouni; Belayachi, Jihane; Madani, Naoufal; Abouqal, Redouane; Zeggwagh, Amine Ali; Ghadhoune, Hatem; Chaari, Anis; Jihene, Guissouma; Allouche, Hend; Trabelsi, Insaf; Brahmi, Habib; Samet, Mohamed; Ghord, Hatem El; Habiba, Ben Sik Ali; Hajer, Nouira; Tilouch, Najla; Yaakoubi, Sondes; Jaoued, Oussama; Gharbi, Rim; Hassen, Mohamed Fekih; Elatrous, Souheil; Arcizet, Julien; Leroy, Bertrand; Abdulmalack, Caroline; Renzullo, Catherine; Hamet, Maël; Doise, Jean-Marc; Coutet, Jérôme; Cheikh, Chaigar Mohammed; Quechar, Zakaria; Joris, Magalie; Beauport, Dimitri Titeca; Kontar, Loay; Lebon, Delphine; Gruson, Bérengère; Slama, Michel; Marolleau, Jean-Pierre; Maizel, Julien; Gorham, Julie; Ameye, Lieveke; Berghmans, Thierry; Paesmans, Marianne; Sculier, Jean-Paul; Meert, Anne-Pascale; Guillot, Max; Ledoux, Marie-Pierre; Braun, Thierry; Maestraggi, Quentin; Michard, Baptiste; Castelain, Vincent; Herbrecht, Raoul; Schneider, Francis; Couffin, Severine; Lobo, David; Mongardon, Nicolas; Dhonneur, Gilles; Mounier, Roman; Le Borgne, Pierrick; Couraud, Sophie; Herbrecht, Jean-Etienne; Boivin, Alexandra; Lefebvre, François; Bilbault, Pascal; Zelmat, Setti-Aouicha; Batouche, Djamila-Djahida; Mazour, Fatima; Chaffi, Belkacem; Benatta, Nadia; Sik, Ali Habiba; Talik, I.; Perrier, Maxime; Gouteix, Eliane; Koubi, Claude; Escavy, Annabelle; Guilbaut, Victoria; Fosse, Jean-Philippe; Jazia, Rahma Ben; Abdelghani, Ahmed; Cungi, Pierre-Julien; Bordes, Julien; Nguyen, Cédric; Pierrou, Candice; Cruc, Maximilien; Benois, Alain; Duprez, Frédéric; Bonus, Thierry; Cuvelier, Grégory; Ollieuz, Sandra; Machayekhi, Sharam; Paciorkowski, Frédéric; Reychler, Gregory; Coudroy, Remi; Thille, Arnaud W.; Drouot, Xavier; Diaz, Véronique; Meurice, Jean-Claude; Robert, René; Turki, Olfa; Ben, Hmida Chokri; Assefi, Mona; Deransy, Romain; Brisson, Hélène; Monsel, Antoine; Conti, Filomena; Scatton, Olivier; Langeron, Olivier; Ghezala, Hassen Ben; Snouda, Salah; Ben, Chiekh Imen; Kaddour, Moez; Armel, Anwar; Youness, Lafrikh; Abdelhak, Bensaid; Youssef, Miloudi; Najib, Al Harrar; Mustapha, Amouzoun; Noufel, Mtioui; Mohamed, Zamd; Salma, El Khayat; Ghizlane, Medkouri; Mohamed, Benghanam; Benyounes, Ramdani; Montini, Florent; Moschietto, Sébastien; Gregoire, Emilien; Claisse, Guillaume; Guiot, Julien; Morimont, Philippe; Krzesinski, Jean-Marie; Mariat, Christophe; Lambermont, Bernard; Cavalier, Etienne; Delanaye, Pierre; Benbernou, Soumia; Ilies, Sofiane; Azza, Abdelkader; Bouyacoub, Khalida; Louail, Meriem; Mokhtari-Djebli, Houria; Arrestier, Romain; Daviaud, Fabrice; Francois, Xavier Laborne; Brocas, Elsa; Choukroun, Gérald; Peñuelas, Oscar; Lorente, José-Angel; Cardinal-Fernandez, Pablo; Rodriguez, José-Maria; Aramburu, José-Antonio; Esteban, Andres; Frutos-Vivar, Fernando; Bitker, Laurent; Costes, Nicolas; Le Bars, Didier; Lavenne, Franck; Devouassoux, Mojgan; Richard, Jean-Christophe; Mechati, Malika; Gainnier, Marc; Papazian, Laurent; Guervilly, Christophe; Garnero, Aude; Arnal, Jean Michel; Roze, Hadrien; Richard, Jean Christophe; Repusseau, Benjamin; Dewitte, Antoine; Joannes-Boyau, Olivier; Ouattara, Alexandre; Harbouze, Nadia; Amine, A. M.; Olandzobo, A. G.; Herbland, Alexandre; Richard, Marie; Girard, Nicolas; Lambron, Lucile; Lesieur, Olivier; Wainschtein, Sarah; Hubert, Sidonie; Hugues, Albane; Tran, Marc; Bouillard, Philippe; Loteanu, Vlad; Leloup, Maxime; Laurent, Alexandra; Lheureux, Florent; Prestifilippo, Alessia; Cruz, Martin Delgado Maria; Romain, Rigal; Antonelli, Massimo; Blanch, Torra Lluis; Bonnetain, Franck; Grazzia-Bocci, Maria; Mancebo, Jordi; Samain, Emmanuel; Paul, Hebert; Capellier, Gilles; Zavgorodniaia, Taissa; Soichot, Marion; Malissin, Isabelle; Voicu, Sebastian; Garçon, Pierre; Goury, Antoine; Kerdjana, Lamia; Deye, Nicolas; Bourgogne, Emmanuel; Megarbane, Bruno; Mejri, Olfa; Hmida, Marwa Ben; Tannous, Salma; Chevillard, Lucie; Labat, Laurence; Risede, Patricia; Fredj, Hana; Léger, Maxime; Brunet, Marion; Le Roux, Gaël; Boels, David; Lerolle, Nicolas; Farah, Souaad; Amiel-Niemann, Hélène; Kubis, Nathalie; Declèves, Xavier; Peyraux, Nicoals; Baud, Frederic; Serafini, Micaela; Alvarez, Jean-Claude; Heinzelman, Annette; Jozwiak, Mathieu; Millasseau, Sandrine; Teboul, Jean-Louis; Alphonsine, Jean-Emmanuel; Depret, François; Richard, Nathalie; Attal, Pierre; Richard, Christian; Monnet, Xavier; Chemla, Denis; Jerbi, Salma; Khedhiri, Wafa; Necib, Hatem; Scarfo, Paolo; Chevalier, Charles; Piagnerelli, Michael; Lafont, Alexandre; Galy, Antoine; Mancia, Claire; Zerhouni, Amel; Tabeliouna, Kheira; Gaja, Ali; Hamrouni, Bassem; Malouch, Abir; Fourati, Sami; Messaoud, Rihab; Zarrouki, Youssef; Ziadi, Amra; Rhezali, Manal; Zouizra, Zahira; Boumzebra, Drissi; Samkaoui, Mohamed Abdennasser; Brunet, Jennifer; Canoville, Bertrand; Verrier, Pierre; Ivascau, Calin; Seguin, Amélie; Valette, Xavier; Du Cheyron, Damien; Daubin, Cedric; Bougouin, Wulfran; Aissaoui, Nadia; Lamhaut, Lionel; Jost, Daniel; Maupain, Carole; Beganton, Frankie; Bouglé, Adrien; Dumas, Florence; Marijon, Eloi; Jouven, Xavier; Cariou, Alain; Poirson, Florent; Chaput, Ulriikka; Beeken, Thomas; Maxime, Leclerc; Haikel, Oueslati; Vodovar, Dominique; Chelly, Jonathan; Marteau, Philippe; Chocron, Richard; Juvin, Philippe; Loeb, Thomas; Adnet, Frederic; Lecarpentier, Eric; Riviere, Antoine; De Cagny, Bertand; Soupison, Thierry; Privat, Elodie; Escutnaire, Joséphine; Dumont, Cyrielle; Baert, Valentine; Vilhelm, Christian; Hubert, Hervé; Leteurtre, Stéphane; Fresco, Marion; Bubenheim, Michael; Beduneau, Gaetan; Carpentier, Dorothée; Grange, Steven; Artaud-Macari, Elise; Misset, Benoit; Tamion, Fabienne; Girault, Christophe; Dumas, Guillaume; Chevret, Sylvie; Lemiale, Virginie; Mokart, Djamel; Mayaux, Julien; Pène, Frédéric; Nyunga, Martine; Perez, Pierre; Moreau, Anne-Sophie; Bruneel, Fabrice; Vincent, François; Klouche, Kada; Reignier, Jean; Rabbat, Antoine; Azoulay, Elie; Frat, Jean-Pierre; Ragot, Stéphanie; Constantin, Jean-Michel; Prat, Gwenael; Mercat, Alain; Boulain, Thierry; Demoule, Alexandre; Devaquet, Jérôme; Nseir, Saad; Charpentier, Julien; Argaud, Laurent; Beuret, Pascal; Ricard, Jean-Damien; Teiten, Christelle; Marjanovic, Nicolas; Palamin, Nicola; L’Her, Erwan; Bailly, Arthur; Boisramé-Helms, Julie; Champigneulle, Benoit; Kamel, Toufik; Mercier, Emmanuelle; Le Thuaut, Aurélie; Lascarrou, Jean-Baptiste; Rolle, Amélie; De Jong, Audrey; Chanques, Gérald; Jaber, Samir; Hariri, Geoffroy; Baudel, Jean-Luc; Dubée, Vincent; Preda, Gabriel; Bourcier, Simon; Joffre, Jeremie; Bigé, Naïke; Ait-Oufella, Hafid; Maury, Eric; Mater, Houda; Merdji, Hamid; Grimaldi, David; Rousseau, Christophe; Mira, Jean-Paul; Chiche, Jean-Daniel; Sedghiani, Ines; Benabderrahim, A.; Hamdi, Dhekra; Jendoubi, Asma; Cherif, Mohamed Ali; Hechmi, Youssef Zied El; Zouheir, Jerbi; Bagate, François; Bousselmi, Radhwen; Schortgen, Frédérique; Asfar, Pierre; Guérot, Emmanuel; Fabien, Grelon; Anguel, Nadia; Sigismond, Lasocki; Matthieu, Henry-Lagarrigue; Gonzalez, Frédéric; François, Legay; Guitton, Christophe; Schenck, Maleka; Jean-Marc, Doise; Dreyfuss, Didier; Radermacher, Peter; Frère, Antoine; Martin-Lefèvre, Laurent; Colin, Gwenhaël; Fiancette, Maud; Henry-Laguarrigue, Matthieu; Lacherade, Jean-Claude; Lebert, Christine; Vinatier, Isabelle; Yehia, Aihem; Joret, Aurélie; Menunier-Beillard, Nicolas; Benzekri-Lefevre, Dalila; Desachy, Arnaud; Bellec, Fréderic; Plantefève, Gaëtan; Quenot, Jean-Pierre; Meziani, Ferhat; Tavernier, Elsa; Ehrmann, Stephan; Chudeau, Nicolas; Raveau, Tommy; Moal, Valérie; Houillier, Pascal; Rouve, Emmanuelle; Lakhal, Karim; Gandonnière, Charlotte Salmon; Jouan, Youenn; Bodet-Contentin, Laetitia; Balmier, Adrien; Messika, Jonathan; De Montmollin, Etienne; Pouyet, Victorine; Sztrymf, Benjamin; Thiagarajah, Abirami; Roux, Damien; De Chambrun, Marc Pineton; Luyt, Charles-Edouard; Beloncle, François; Zapella, Nathalie; Ledochowsky, Stanislas; Terzi, Nicolas; Mazou, Jean-Marc; Sonneville, Romain; Paulus, Sylvie; Fedun, Yannick; Landais, Mickael; Raphalen, Jean-Herlé; Combes, Alain; Amoura, Zahir; Jacquemin, Aemilia; Guerrero, Felipe; Marcheix, Bertrand; Hernandez, Nicolas; Fourcade, Olivier; Georges, Bernard; Delmas, Clément; Makoudi, Sarah; Genton, Audrey; Bernard, Rémy; Lebreton, Guillaume; Amour, Julien; Mazet, Charlotte; Bounes, Fanny; Murat, Gurbuz; Cronier, Laure; Robin, Guillaume; Biendel, Caroline; Silva, Stein; Boubeche, Samia; Abriou, Caroline; Wurtz, Véronique; Scherrer, Vincent; Rey, Nathalie; Gastaldi, Gioia; Veber, Benoit; Doguet, Fabien; Gay, Arnaud; Dureuil, Bertrand; Besnier, Emmanuel; Rouget, Antoine; Gantois, Guillaume; Magalhaes, Eric; Wanono, Ruben; Smonig, Roland; Lermuzeaux, Mathilde; Lebut, Jordane; Olivier, Andremont; Dupuis, Claire; Radjou, Aguila; Mourvillier, Bruno; Neuville, Mathilde; D’ortho, Marie Pia; Bouadma, Lila; Rouvel-Tallec, Anny; Rudler, Marika; Weiss, Nicolas; Perlbarg, Vincent; Galanaud, Damien; Thabut, Dominique; Rachdi, Emna; Mhamdi, Ghada; Trifi, Ahlem; Abdelmalek, Rim; Abdellatif, Sami; Daly, Foued; Nasri, Rochdi; Tiouiri, Hanene; Lakhal, Salah Ben; Rousseau, Geoffroy; Asmolov, Romain; Grammatico-Guillon, Leslie; Auvet, Adrien; Laribi, Said; Garot, Denis; Dequin, Pierre François; Guillon, Antoine; Fergé, Jean-Louis; Abgrall, Gwénolé; Hinault, Ronan; Vally, Shazima; Roze, Benoit; Chaplain, Agathe; Chabartier, Cyrille; Savidan, Anne-Charlotte; Marie, Sabia; Cabie, Andre; Resiere, Dabor; Valentino, Ruddy; Mehdaoui, Hossein; Benarous, Lucas; Soda-Diop, Marième; Bouzana, Fouad; Perrin, Gilles; Bourenne, Jeremy; Eon, Béatrice; Lambert, Dominique; Trebuchon, Agnes; Poncelet, Géraldine; Le Bourgeois, Fleur; Michael, Levy; Camille, Guillot; Naudin, Jérôme; Deho, Anna; Dauger, Stéphane; Sauthier, Michaël; Bergeron-Gallant, Krystale; Emeriaud, Guillaume; Jouvet, Philippe; Tiebergien, Nicolas; Jacquet-Lagrèze, Matthias; Fellahi, Jean-Luc; Baudin, Florent; Essouri, Sandrine; Javouhey, Etienne; Guérin, Claude; Lampin, Marie; Mamouri, Ouardia; Devos, Patrick; Karaca-Altintas, Yasemin; Vinchon, Matthieu; Brossier, David; Eltaani, Redha; Teyssedre, Sonia; Sabine, Meyet; Bouchut, Jean-Christophe; Peguet, Olivier; Petitdemange, Lucie; Guilbert, Anne Sophie; Aoul, Nabil Tabet; Addou, Zakaria; Aouffen, Nabil; Anas, Benqqa; Kalouch, Samira; Yaqini, Khalid; Chlilek, Aziz; Abdou, Rchi; Gravellier, Perrine; Chantreuil, Julie; Travers, Nadine; Listrat, Antoine; Le Reun, Claire; Favrais, Geraldine; Coppere, Zoe; Blanot, Stéphane; Montmayeur, Juliette; Bronchard, Régis; Rolando, Stephane; Orliaguet, Gilles; Leger, Pierre-Louis; Rambaud, Jérôme; Thueux, Emilie; De Larrard, Alexandra; Berthelot, Véronique; Denot, Julien; Reymond, Marie; Amblard, Alain; Morin-Zorman, Sarah; Lengliné, Etienne; Pichereau, Claire; Mariotte, Eric; Emmanuel, Canet; Poujade, Julien; Trumpff, Guillaume; Janssen-Langenstein, Ralf; Harlay, Marie-Line; Zaid, Noorah; Ait-Ammar, Nawel; Bonnal, Christine; Merle, Jean-Claude; Botterel, Francoise; Levesque, Eric; Riad, Zakaria; Mezidi, Mehdi; Yonis, Hodane; Aublanc, Mylène; Perinel-Ragey, Sophie; Lissonde, Floriane; Louf-Durier, Aurore; Tapponnier, Romain; Louis, Bruno; Forel, Jean-Marie; Bisbal, Magali; Lehingue, Samuel; Rambaud, Romain; Adda, Mélanie; Hraiech, Sami; Marchi, Elisa; Roch, Antoine; Guerin, Vincent; Rozencwajg, Sacha; Schmidt, Matthieu; Hekimian, Guillaume; Bréchot, Nicolas; Trouillet, Jean Louis; Besset, Sébastien; Franchineau, Guillaume; Nieszkowska, Ania; Pascal, Leprince; Loiselle, Maud; Sarah, Chemam; Laurence, Dangers; Guillemette, Thomas; Jacquens, Alice; Kerever, Sebastien; Guidet, Bertrand; Aegerter, Philippe; Das, Vincent; Fartoukh, Muriel; Hayon, Jan; Desmard, Mathieu; Fulgencio, Jean-Pierre; Zuber, Benjamin; Soufi, A.; Khaleq, K.; Hamoudi, D.; Garret, Charlotte; Peron, Matthieu; Coron, Emmanuel; Bretonnière, Cédric; Audureau, Etienne; Audrey, Winters; Christophe, Duvoux; Christian, Jacquelinet; Daniel, Azoulay; Cyrille, Feray; Aissaoui, Wissal; Rghioui, Kawtar; Haddad, Wafae; Barrou, Houcine; Carteaux-Taeib, Anna; Lupinacci, Renato; Manceau, Gilles; Jeune, Florence; Tresallet, Christophe; Habacha, Sahar; Fathallah, Ines; Zoubli, Aymen; Aloui, Rafaa; Kouraichi, Nadia; Jouet, Emilie; Badin, Julie; Fermier, Brice; Feller, Marc; Serie, Mathieu; Pillot, Jérôme; Marie, William; Gisbert-Mora, Chloé; Vinclair, Camille; Lesbordes, Pierre; Mathieu, Pascal; De Brabant, Fabienne; Muller, Emmanuel; Robaux, Marie-Aline; Giabicani, Mikhael; Marchalot, Antoine; Gelinotte, Stéphanie; Declercq, Pierre Louis; Eraldi, Jean-Pierre; Bougerol, François; Meunier-Beillard, Nicolas; Devilliers, Hervé; Rigaud, Jean-Philippe; Verrière, Camille; Ardisson, Fanny; Kentish-Barnes, Nancy; Jacq, Gwenaëlle; Chermak, Akli; Lautrette, Alexandre; Legrand, Matthieu; Soummer, Alexis; Thiery, Guillaume; Cottereau, Alice; Canet, Emmanuel; Caujolle, Marie; Allyn, Jérôme; Valance, Dorothée; Brulliard, Caroline; Martinet, Olivier; Jabot, Julien; Gallas, Thomas; Vandroux, David; Allou, Nicolas; Durand, Arthur; Nevière, Rémi; Delguste, Florian; Boulanger, Eric; Preau, Sebastien; Martin, Ruste; Cochet, Hélène; Ponthus, Jean Pierre; Amilien, Virginie; Tchir, Martial; Barsam, Elise; Ayoub, Mohsen; Georger, Jean Francois; Guillame, Izaute; Assaraf, Julie; Tripon, Simona; Mallet, Maxime; Barbara, Guilaume; Louis, Guillaume; Gaudry, Stéphane; Barbarot, Nicolas; Jamet, Angéline; Outin, Hervé; Gibot, Sébastien; Bollaert, Pierre-Edouard; Holleville, Mathilde; Legriel, Stéphane; Chateauneuf, Anne Laure; Cavelot, Sébastien; Moyer, Jean-Denis; Bedos, Jean Pierre; Merle, Philippe; Laine, Aurelie; Natalie, De Sa; Cornuault, Mathieu; Libot, Jérome; Asehnoune, Karim; Rozec, Bertrand; Dantal, Jacques; Videcoq, Michel; Degroote, Thècle; Jaillette, Emmanuelle; Zerimech, Farid; Malika, Balduyck; Llitjos, Jean-François; Amara, Marlène; Lacave, Guillaume; Pangon, Béatrice; Mavinga, José; Makunza, Joseph Nsiala; Mafuta, M. E.; Yanga, Yves; Eric, Amisi; Ilunga, Jp; Kilembe, Ma; Alby-Laurent, Fanny; Toubiana, Julie; Mokline, Amel; Laajili, Achraf; Amri, Helmi; Rahmani, Imene; Mensi, Nidhal; Gharsallah, Lazheri; Tlaili, Sofiene; Gasri, Bahija; Hammouda, Rym; Messadi, Amen Allah; Allain, Pierre-Antoine; Gault, Nathallie; Paugam-Burtz, Catherine; Foucrier, Arnaud; Chatbri, Bassem; Bourbiaa, Yousra; Thabet, Lamia; Neuschwander, Arthur; Vincent, Looten; Beck, Jennifer; Vibol, Chhor; Amelie, Yavchitz; Resche-Rigon, Matthieu; Pirracchio, Jean MantzRomain; Bureau, Côme; Decavèle, Maxens; Campion, Sébastien; Ainsouya, Roukia; Niérat, Marie-Cécile; Prodanovic, Hélène; Raux, Mathieu; Similowski, Thomas; Dubé, Bruno-Pierre; Demiri, Suela; Dres, Martin; May, Faten; Quintard, Hervé; Kounis, Ilias; Saliba, Faouzi; André, Stephane; Boudon, Marc; Ichai, Philippe; Younes, Aline; Nakad, Lionel; Coilly, Audrey; Antonini, Teresa; Sobesky, Rodolphe; De Martin, Eleonora; Samuel, Didier; Hubert, Noemie; Nay, Mai-Anh; Auchabie, Johann; Giraudeau, Bruno; Jean, Reignier; Darmon, Michaël; Ruckly, Stephane; Garrouste-Orgeas, Maïté; Gratia, Elisabeth; Goldgran-Toledano, Dany; Jamali, Samir; Dumenil, Anne Sylvie; Schwebel, Carole; Brisard, Laurent; Bizouarn, Philippe; Lepoivre, Thierry; Nicolet, Johanna; Rigal, Jean Christophe; Roussel, Jean Christian; Cheurfa, Cherifa; Abily, Julien; Lescot, Thomas; Page, Isaline; Warnier, Stéphanie; Nys, Monique; Rousseau, Anne-Françoise; Damas, Pierre; Uhel, Fabrice; Lesouhaitier, Mathieu; Grégoire, Murielle; Gaudriot, Baptiste; Gacouin, Arnaud; Le Tulzo, Yves; Flecher, Erwan; Tarte, Karin; Tadié, Jean-Marc; Georges, Quentin; Soares, M.; Jeon, Kyeongman; Oeyen, Sandra; Rhee, Chin Kook; Gruber, Pascale; Ostermann, Marlies; Hill, Quentin; Depuydt, Peter; Ferra, Christelle; Muller, Alice; Aurelie, Bourmaud; Niles, Christopher; Herbert, Fabien; Pied, Sylviane; Loridant, Séverine; François, Nadine; Bignon, Anne; Sendid, Boualem; Lemaitre, Caroline; Dupre, Celine; Zayene, Aymen; Portier, Lucie; De Freitas Caires, Nathalie; Lassalle, Philippe; Le Neindre, Aymeric; Selot, Pascal; Ferreiro, Daniel; Bonarek, Maria; Henriot, Stépahen; Rodriguez, Julie; Taddei, Mara; Di Bari, Mauro; Hickmann, Cheryl; Castanares-Zapatero, Diego; Deldicque, Louise; Van Den Bergh, Peter; Caty, Gilles; Roeseler, Jean; Francaux, Marc; Laterre, Pierre-François; Dupuis, Bastien; Machayeckhi, Sharam; Sarfati, Celine; Moore, Alex; Mendialdua, Paula; Rodet, Emilie; Pilorge, Catherine; Stephan, Francois; Rezaiguia-Delclaux, Saida; Dugernier, Jonathan; Hesse, Michel; Jumetz, Thibaud; Bialais, Emilie; Depoortere, Virginie; Michotte, Jean Bernard; Wittebole, Xavier; Jamar, François title: Proceedings of Réanimation 2017, the French Intensive Care Society International Congress date: 2017-01-10 journal: Ann Intensive Care DOI: 10.1186/s13613-016-0224-7 sha: doc_id: 14538 cord_uid: 6a2pviol file: cache/cord-011222-7aha5b07.json /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes key: cord-011222-7aha5b07 authors: Huang, Cheng-Chi; Muo, Chih-Hsin; Wu, Tain-Fung; Chi, Tung-Yun; Shen, Te-Chun; Hsia, Te-Chun; Shih, Chuen-Ming title: The application of non-invasive and invasive mechanical ventilation in the first episode of acute respiratory failure date: 2020-03-30 journal: Intern Emerg Med DOI: 10.1007/s11739-020-02315-1 sha: doc_id: 11222 cord_uid: 7aha5b07 file: cache/cord-016844-lq2bgu7a.json /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes key: cord-016844-lq2bgu7a authors: Teksam, Ozlem; Bayrakci, Benan title: Noninvasive Mechanical Ventilation in Patients with High-Risk Infections and Mass Casualties in Acute Respiratory Failure: Pediatric Perspective date: 2013-05-29 journal: Noninvasive Ventilation in High-Risk Infections and Mass Casualty Events DOI: 10.1007/978-3-7091-1496-4_29 sha: doc_id: 16844 cord_uid: lq2bgu7a file: cache/cord-015548-zjrkfe9b.json /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes key: cord-015548-zjrkfe9b authors: Popat, Bhavesh; Jones, Andrew T. title: Invasive and non-invasive mechanical ventilation date: 2012-05-18 journal: Medicine (Abingdon) DOI: 10.1016/j.mpmed.2012.03.010 sha: doc_id: 15548 cord_uid: zjrkfe9b file: cache/cord-034578-i9rdubix.json key: cord-034578-i9rdubix authors: Vaschetto, Rosanna; Barone-Adesi, Francesco; Racca, Fabrizio; Pissaia, Claudio; Maestrone, Carlo; Colombo, Davide; Olivieri, Carlo; De Vita, Nello; Santangelo, Erminio; Scotti, Lorenza; Castello, Luigi; Cena, Tiziana; Taverna, Martina; Grillenzoni, Luca; Moschella, Maria Adele; Airoldi, Gianluca; Borrè, Silvio; Mojoli, Francesco; Della Corte, Francesco; Navalesi, Paolo; Cammarota, Gianmaria; Baggiani, Marta; Baino, Sara; Balbo, Piero; Bazzano, Simona; Bonato, Valeria; Carbonati, Sara; Crimaldi, Federico; Daffara, Veronica; De Col, Luca; Maestrone, Matteo; Malerba, Mario; Moroni, Federica; Perucca, Raffaella; Pirisi, Mario; Rondi, Valentina; Rosalba, Daniela; Vanni, Letizia; Vigone, Francesca title: Outcomes of COVID-19 patients treated with continuous positive airway pressure outside ICU date: 2020-10-30 journal: ERJ Open Res DOI: 10.1183/23120541.00541-2020 sha: doc_id: 34578 cord_uid: i9rdubix file: cache/cord-010850-zj6k7wz9.json /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes key: cord-010850-zj6k7wz9 authors: Holbird, Samantha; Holt, Tanya; Shaw, Adam; Hansen, Gregory title: Noninvasive ventilation for pediatric interfacility transports: a retrospective study date: 2020-05-13 journal: World J Pediatr DOI: 10.1007/s12519-020-00363-3 sha: doc_id: 10850 cord_uid: zj6k7wz9 file: cache/cord-017786-kfl6xt31.json /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes key: cord-017786-kfl6xt31 authors: Curiel-Balsera, Emilio; García-Trujillo, Elena title: Guidelines for Health Organizations: European Perspectives and Experience in Pandemics date: 2013-05-29 journal: Noninvasive Ventilation in High-Risk Infections and Mass Casualty Events DOI: 10.1007/978-3-7091-1496-4_41 sha: doc_id: 17786 cord_uid: kfl6xt31 file: cache/cord-103020-ckuma42j.json key: cord-103020-ckuma42j authors: McDowell, G.; Sumowski, M.; Toellner, H.; Karok, S.; O'Dwyer, C.; Hornsby, J.; Lowe, D.; Carlin, C. title: Two-way remote monitoring allows effective and realistic provision of home-NIV to COPD patients with persistent hypercapnia. date: 2020-11-12 journal: nan DOI: 10.1101/2020.11.08.20227892 sha: doc_id: 103020 cord_uid: ckuma42j file: cache/cord-260220-f1tpkw1o.json key: cord-260220-f1tpkw1o authors: Timenetsky, Karina T; Aquino, Silvia HCT; Saghabi, Cilene; Taniguchi, Corinne; Silvia, Claudia V; Correa, Luci; Marra, Alexandre R; Eid, Raquel AC; dos Santos, Oscar FP title: High success and low mortality rates with non-invasive ventilation in influenza A H1N1 patients in a tertiary hospital date: 2011-09-28 journal: BMC Res Notes DOI: 10.1186/1756-0500-4-375 sha: doc_id: 260220 cord_uid: f1tpkw1o file: cache/cord-267537-akzydy7l.json key: cord-267537-akzydy7l authors: Dang, Ha V.; Chan, Yee-Peng; Park, Young-Jun; Snijder, Joost; Da Silva, Sofia Cheliout; Vu, Bang; Yan, Lianying; Feng, Yan-Ru; Rockx, Barry; Geisbert, Thomas W.; Mire, Chad E.; Broder, Christopher C.; Veesler, David title: An antibody against the F glycoprotein inhibits Nipah and Hendra virus infections date: 2019-09-30 journal: Nat Struct Mol Biol DOI: 10.1038/s41594-019-0308-9 sha: doc_id: 267537 cord_uid: akzydy7l file: cache/cord-027526-ohcu28rk.json /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes key: cord-027526-ohcu28rk authors: Zhou, Xiaoyang; Yao, Shengmi; Dong, Pingping; Chen, Bixin; Xu, Zhaojun; Wang, Hua title: Preventive use of respiratory support after scheduled extubation in critically ill medical patients—a network meta-analysis of randomized controlled trials date: 2020-06-22 journal: Crit Care DOI: 10.1186/s13054-020-03090-3 sha: doc_id: 27526 cord_uid: ohcu28rk file: cache/cord-034185-e0am7pa6.json key: cord-034185-e0am7pa6 authors: Piccioni, Federico; Droghetti, Andrea; Bertani, Alessandro; Coccia, Cecilia; Corcione, Antonio; Corsico, Angelo Guido; Crisci, Roberto; Curcio, Carlo; Del Naja, Carlo; Feltracco, Paolo; Fontana, Diego; Gonfiotti, Alessandro; Lopez, Camillo; Massullo, Domenico; Nosotti, Mario; Ragazzi, Riccardo; Rispoli, Marco; Romagnoli, Stefano; Scala, Raffaele; Scudeller, Luigia; Taurchini, Marco; Tognella, Silvia; Umari, Marzia; Valenza, Franco; Petrini, Flavia title: Recommendations from the Italian intersociety consensus on Perioperative Anesthesa Care in Thoracic surgery (PACTS) part 2: intraoperative and postoperative care date: 2020-10-23 journal: Perioper Med (Lond) DOI: 10.1186/s13741-020-00159-z sha: doc_id: 34185 cord_uid: e0am7pa6 file: cache/cord-005727-li8pwigg.json /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: Resource temporarily unavailable key: cord-005727-li8pwigg authors: nan title: ESICM 2010 MONDAY SESSIONS 11 October 2010 date: 2010-08-31 journal: Intensive Care Med DOI: 10.1007/s00134-010-1999-x sha: doc_id: 5727 cord_uid: li8pwigg file: cache/cord-276238-2hv46ftk.json key: cord-276238-2hv46ftk authors: Ing, Richard J.; Bills, Corey; Merritt, Glenn; Ragusa, Rosalia; Bremner, Ross M.; Bellia, Francesco title: The role of helmet-delivered noninvasive pressure support ventilation in COVID-19 patients date: 2020-05-08 journal: J Cardiothorac Vasc Anesth DOI: 10.1053/j.jvca.2020.04.060 sha: doc_id: 276238 cord_uid: 2hv46ftk file: cache/cord-303292-iheq50ub.json key: cord-303292-iheq50ub authors: De Jong, Audrey; Wrigge, Hermann; Hedenstierna, Goran; Gattinoni, Luciano; Chiumello, Davide; Frat, Jean-Pierre; Ball, Lorenzo; Schetz, Miet; Pickkers, Peter; Jaber, Samir title: How to ventilate obese patients in the ICU date: 2020-10-23 journal: Intensive Care Med DOI: 10.1007/s00134-020-06286-x sha: doc_id: 303292 cord_uid: iheq50ub file: cache/cord-293170-ir2y6sfz.json key: cord-293170-ir2y6sfz authors: Lal, Tusharindra; Sircar, Mrinal title: COVID-19 patients: when and whom to ventilate? date: 2020-08-19 journal: Acute Crit Care DOI: 10.4266/acc.2020.00451 sha: doc_id: 293170 cord_uid: ir2y6sfz file: cache/cord-313639-qpt47sx2.json key: cord-313639-qpt47sx2 authors: Zheng, Yi; Sun, Li-jun; Xu, Mi; Pan, Jian; Zhang, Yun-tao; Fang, Xue-ling; Fang, Qiang; Cai, Hong-liu title: Clinical characteristics of 34 COVID-19 patients admitted to intensive care unit in Hangzhou, China date: 2020-05-20 journal: J Zhejiang Univ Sci B DOI: 10.1631/jzus.b2000174 sha: doc_id: 313639 cord_uid: qpt47sx2 file: cache/cord-309518-seonrtn3.json key: cord-309518-seonrtn3 authors: Alraddadi, Basem M.; Qushmaq, Ismael; Al‐Hameed, Fahad M.; Mandourah, Yasser; Almekhlafi, Ghaleb A.; Jose, Jesna; Al‐Omari, Awad; Kharaba, Ayman; Almotairi, Abdullah; Al Khatib, Kasim; Shalhoub, Sarah; Abdulmomen, Ahmed; Mady, Ahmed; Solaiman, Othman; Al‐Aithan, Abdulsalam M.; Al‐Raddadi, Rajaa; Ragab, Ahmed; Balkhy, Hanan H.; Al Harthy, Abdulrahman; Sadat, Musharaf; Tlayjeh, Haytham; Merson, Laura; Hayden, Frederick G.; Fowler, Robert A.; Arabi, Yaseen M. title: Noninvasive ventilation in critically ill patients with the Middle East respiratory syndrome date: 2019-03-18 journal: Influenza Other Respir Viruses DOI: 10.1111/irv.12635 sha: doc_id: 309518 cord_uid: seonrtn3 file: cache/cord-330704-4piesfxu.json key: cord-330704-4piesfxu authors: Avdeev, Sergey N.; Yaroshetskiy, Andrey I.; Tsareva, Natalia A.; Merzhoeva, Zamira M.; Trushenko, Natalia V.; Nekludova, Galina V.; Chikina, Svetlana Yu title: Noninvasive ventilation for acute hypoxemic respiratory failure in patients with COVID-19 date: 2020-10-01 journal: Am J Emerg Med DOI: 10.1016/j.ajem.2020.09.075 sha: doc_id: 330704 cord_uid: 4piesfxu file: cache/cord-336690-ajmuaw10.json key: cord-336690-ajmuaw10 authors: McEnery, Tom; Gough, Ciara; Costello, Richard W title: COVID-19: Respiratory support outside the intensive care unit date: 2020-04-09 journal: Lancet Respir Med DOI: 10.1016/s2213-2600(20)30176-4 sha: doc_id: 336690 cord_uid: ajmuaw10 file: cache/cord-313816-7d8x7fjp.json key: cord-313816-7d8x7fjp authors: Cinesi Gómez, C.; Peñuelas Rodríguez, Ó.; Luján Torné, M.l; Egea Santaolalla, C.; Masa Jiménez, J. F.; García Fernández, J.; Carratalá Perales, J. M.; Heili-Frades, S. B.; Ferrer Monreal, M.; de Andrés Nilsson, J. M.; Lista Arias, E.; Sánchez Rocamora, J. L.; Garrote, J. I.; Zamorano Serrano, M. J.; González Martínez, M.; Farrero Muñoz, E.; Mediano San Andrés, O.; Rialp Cervera, G.; Mas Serra, A.; Hernández Martínez, G.; de Haro López, C.; Roca Gas, O.; Ferrer Roca, R.; Romero Berrocal, A.; Ferrando Ortola, C. title: Clinical Consensus Recommendations Regarding Non-Invasive Respiratory Support in the Adult Patient with Acute Respiratory Failure Secondary to SARS-CoV-2 infection date: 2020-05-07 journal: nan DOI: 10.1016/j.redare.2020.05.001 sha: doc_id: 313816 cord_uid: 7d8x7fjp file: cache/cord-027805-p0bhju1s.json /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes key: cord-027805-p0bhju1s authors: Wong, An-Kwok Ian; Cheung, Patricia C.; Happ, Mary Beth; Gay, Peter C.; Collop, Nancy A. title: Consequences and Solutions for the Impact of Communication Impairment on Noninvasive Ventilation Therapy for Acute Respiratory Failure: A Focused Review date: 2020-06-15 journal: Crit Care Explor DOI: 10.1097/cce.0000000000000121 sha: doc_id: 27805 cord_uid: p0bhju1s file: cache/cord-352059-1bjskqyg.json key: cord-352059-1bjskqyg authors: Gupta, Nivedita; Potdar, Varsha; Praharaj, Ira; Giri, Sidhartha; Sapkal, Gajanan; Yadav, Pragya; Choudhary, Manohar Lal; Dar, Lalit; Sugunan, A.P.; Kaur, Harmanmeet; Munivenkatappa, Ashok; Shastri, Jayanthi; Kaveri, Krishnasamy; Dutta, Shanta; Malhotra, Bharti; Jain, Amita; Nagamani, Kammilli; Shantala, G.B.; Raut, Sharmila; Vegad, M.M.; Sharma, Ajanta; Choudhary, Aashish; Brijwal, Megha; Balakrishnan, Anukumar; Manjunatha, Jayaswamy; Pathak, Manish; Srinivasan, Sivasubramanian; Banu, Hasina; Sharma, Himanshu; Jain, Parul; Sunita, Pakalpati; Ambica, R.; Fageria, Babita; Patel, Disha; Rajbongshi, Gitika; Vijay, Neetu; Narayan, Jitendra; Aggarwal, Neeraj; Nagar, Anu; Gangakhedkar, Raman R.; Abraham, Priya title: Laboratory preparedness for SARS-CoV-2 testing in India: Harnessing a network of Virus Research & Diagnostic Laboratories date: 2020-04-28 journal: Indian J Med Res DOI: 10.4103/ijmr.ijmr_594_20 sha: doc_id: 352059 cord_uid: 1bjskqyg file: cache/cord-290684-3f6prlqy.json /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes key: cord-290684-3f6prlqy authors: Duan, Jun; Chen, Baixu; Liu, Xiaoyi; Shu, Weiwei; Zhao, Wei; Li, Ji; Li, Yishi; Hong, Yueling; Pan, Longfang; Wang, Ke title: Use of high-flow nasal cannula and noninvasive ventilation in patients with COVID-19: A multicenter observational study date: 2020-07-29 journal: Am J Emerg Med DOI: 10.1016/j.ajem.2020.07.071 sha: doc_id: 290684 cord_uid: 3f6prlqy file: cache/cord-352850-as12ll8s.json key: cord-352850-as12ll8s authors: Wang, Tao; Tang, Chunli; Chen, Ruchong; Ruan, Honglian; Liang, Wenhua; Guan, Weijie; Sang, Ling; Tang, Ruidi; Zhong, Nanshan; Li, Shiyue title: Clinical Features of Coronavirus Disease 2019 Patients With Mechanical Ventilation: A Nationwide Study in China date: 2020-06-23 journal: Crit Care Med DOI: 10.1097/ccm.0000000000004473 sha: doc_id: 352850 cord_uid: as12ll8s file: cache/cord-335078-z7k59k8o.json key: cord-335078-z7k59k8o authors: Burton-Papp, Helmi C.; Jackson, Alexander I. R.; Beecham, Ryan; Ferrari, Matteo; Nasim-Mohi, Myra; Grocott, Michael P. W.; Chambers, Robert; Dushianthan, Ahilanandan title: Conscious prone positioning during non-invasive ventilation in COVID-19 patients: experience from a single centre date: 2020-07-31 journal: F1000Res DOI: 10.12688/f1000research.25384.1 sha: doc_id: 335078 cord_uid: z7k59k8o file: cache/cord-327622-ezgufe24.json /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes key: cord-327622-ezgufe24 authors: Kaur, Ramandeep; Weiss, Tyler T.; Perez, Andrew; Fink, James B.; Chen, Rongchang; Luo, Fengming; Liang, Zongan; Mirza, Sara; Li, Jie title: Practical strategies to reduce nosocomial transmission to healthcare professionals providing respiratory care to patients with COVID-19 date: 2020-09-23 journal: Crit Care DOI: 10.1186/s13054-020-03231-8 sha: doc_id: 327622 cord_uid: ezgufe24 file: cache/cord-344641-rog2h4g7.json key: cord-344641-rog2h4g7 authors: Franco, Cosimo; Facciolongo, Nicola; Tonelli, Roberto; Dongilli, Roberto; Vianello, Andrea; Pisani, Lara; Scala, Raffaele; Malerba, Mario; Carlucci, Annalisa; Negri, Emanuele Alberto; Spoladore, Greta; Arcaro, Giovanna; Tillio, Paolo Amedeo; Lastoria, Cinzia; Schifino, Gioachino; Tabbi’, Luca; Guidelli, Luca; Guaraldi, Giovanni; Ranieri, V. Marco; Clini, Enrico; Nava, Stefano title: Feasibility and clinical impact of out-of-ICU non-invasive respiratory support in patients with COVID-19 related pneumonia date: 2020-08-03 journal: Eur Respir J DOI: 10.1183/13993003.02130-2020 sha: doc_id: 344641 cord_uid: rog2h4g7 file: cache/cord-354330-pud2rqxk.json key: cord-354330-pud2rqxk authors: Pirzada, Abdul Rouf; Aleissi, Salih A.; Almeneessier, Aljohara S.; BaHammam, Ahmed Salem title: Management of Aerosol during Noninvasive Ventilation for Patients with Sleep-Disordered Breathing: Important Messages during the COVID-19 Pandemic date: 2020-06-17 journal: Sleep Vigil DOI: 10.1007/s41782-020-00092-7 sha: doc_id: 354330 cord_uid: pud2rqxk file: cache/cord-355450-v3eh1rtk.json key: cord-355450-v3eh1rtk authors: Boattini, Matteo; Almeida, André; Christaki, Eirini; Cruz, Lourenço; Antão, Diogo; Moreira, Maria Inês; Bianco, Gabriele; Iannaccone, Marco; Tsiolakkis, Georgios; Khattab, Elina; Kasapi, Diamanto; Charrier, Lorena; Tosatto, Valentina; Marques, Torcato Moreira; Cavallo, Rossana; Costa, Cristina title: Influenza and respiratory syncytial virus infections in the oldest-old continent date: 2020-06-27 journal: Eur J Clin Microbiol Infect Dis DOI: 10.1007/s10096-020-03959-9 sha: doc_id: 355450 cord_uid: v3eh1rtk file: cache/cord-312864-km07zhn1.json /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes key: cord-312864-km07zhn1 authors: Potalivo, A.; Montomoli, J.; Facondini, F.; Sanson, G.; Lazzari Agli, L. A.; Perin, T.; Cristini, F.; Cavagna, E.; De Giovanni, R.; Biagetti, C.; Panzini, I.; Ravaiolo, C.; Bitondo, M.; Guerra, D.; Giuliani, G.; Mosconi, E.; Guarino, S.; Marchionni, E.; Gangitano, G.; Valentini, I.; Giampaolo, L.; Muratori, F.; Nardi, G. title: Sixty-day mortality among 520 Italian hospitalized COVID-19 patients according to the adopted ventilatory strategy in the context of an integrated multidisciplinary clinical organization: a population-based cohort study date: 2020-08-15 journal: nan DOI: 10.1101/2020.08.13.20174615 sha: doc_id: 312864 cord_uid: km07zhn1 file: cache/cord-335975-m6lkrehi.json /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: Resource temporarily unavailable key: cord-335975-m6lkrehi authors: nan title: Proceedings of Réanimation 2018, the French Intensive Care Society International Congress date: 2018-02-05 journal: Ann Intensive Care DOI: 10.1186/s13613-017-0345-7 sha: doc_id: 335975 cord_uid: m6lkrehi file: cache/cord-352577-h3652seb.json /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: Resource temporarily unavailable key: cord-352577-h3652seb authors: Kopić, Jasminka; Paradžik, Maja Tomić title: Expanding the Use of Noninvasive Ventilation During an Epidemic date: 2014-08-27 journal: Disaster Med Public Health Prep DOI: 10.1017/dmp.2014.71 sha: doc_id: 352577 cord_uid: h3652seb file: cache/cord-010669-rg2p3kal.json /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: Resource temporarily unavailable key: cord-010669-rg2p3kal authors: Fubini, PE; Suppan, L title: Prehospital reversal of profound respiratory acidosis and hypercapnic coma by non-invasive ventilation: a report of two cases date: 2020-05-07 journal: Int J Emerg Med DOI: 10.1186/s12245-020-00284-y sha: doc_id: 10669 cord_uid: rg2p3kal file: cache/cord-268049-7xqln70d.json /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes key: cord-268049-7xqln70d authors: Montrief, Tim; Ramzy, Mark; Long, Brit; Gottlieb, Michael; Hercz, Dan title: COVID-19 respiratory support in the emergency department setting date: 2020-08-08 journal: Am J Emerg Med DOI: 10.1016/j.ajem.2020.08.001 sha: doc_id: 268049 cord_uid: 7xqln70d file: cache/cord-355038-o2hr5mox.json key: cord-355038-o2hr5mox authors: nan title: Proceedings of Réanimation 2020, the French Intensive Care Society International Congress date: 2020-02-11 journal: Ann Intensive Care DOI: 10.1186/s13613-020-0623-7 sha: doc_id: 355038 cord_uid: o2hr5mox file: cache/cord-013149-y0dbhtef.json /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: Resource temporarily unavailable key: cord-013149-y0dbhtef authors: Wohlfarth, P.; Schellongowski, P. title: Hämatoonkologie und Intensivmedizin: Vom Tabu zur Conditio sine qua non date: 2020-10-12 journal: Med Klin Intensivmed Notfmed DOI: 10.1007/s00063-020-00737-5 sha: doc_id: 13149 cord_uid: y0dbhtef file: cache/cord-016897-t71f10kv.json /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes key: cord-016897-t71f10kv authors: Flores, Marco V.; Cohen, Mark title: Preventing Airborne Disease Transmission: Implications for Patients During Mechanical Ventilation date: 2013-05-29 journal: Noninvasive Ventilation in High-Risk Infections and Mass Casualty Events DOI: 10.1007/978-3-7091-1496-4_34 sha: doc_id: 16897 cord_uid: t71f10kv file: cache/cord-346565-vsgbmxzv.json /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/json2txt-carrel.sh: fork: retry: Resource temporarily unavailable key: cord-346565-vsgbmxzv authors: Cascella, Marco; Mauro, Immacolata; De Blasio, Elvio; Crispo, Anna; Del Gaudio, Alfredo; Bimonte, Sabrina; Cuomo, Arturo; Ascierto, Paolo Antonio title: Rapid and Impressive Response to a Combined Treatment with Single-Dose Tocilizumab and NIV in a Patient with COVID-19 Pneumonia/ARDS date: 2020-07-27 journal: Medicina (Kaunas) DOI: 10.3390/medicina56080377 sha: doc_id: 346565 cord_uid: vsgbmxzv Reading metadata file and updating bibliogrpahics === updating bibliographic database Building study carrel named keyword-niv-cord parallel: Warning: Only enough available processes to run 7 jobs in parallel. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf parallel: Warning: or /proc/sys/kernel/pid_max may help. parallel: Warning: Only enough available processes to run 1 jobs in parallel. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf parallel: Warning: or /proc/sys/kernel/pid_max may help. parallel: Warning: Only enough available processes to run 8 jobs in parallel. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf parallel: Warning: or /proc/sys/kernel/pid_max may help. parallel: Warning: No more processes: Decreasing number of running jobs to 6. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: Only enough available processes to run 20 jobs in parallel. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf parallel: Warning: or /proc/sys/kernel/pid_max may help. parallel: Warning: No more processes: Decreasing number of running jobs to 5. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes parallel: Warning: No more processes: Decreasing number of running jobs to 50. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 49. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordent2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes === file2bib.sh === id: cord-029392-5s5686i9 author: Zayed, Yazan title: Effect of oxygenation modalities among patients with postoperative respiratory failure: a pairwise and network meta-analysis of randomized controlled trials date: 2020-07-17 pages: extension: .txt txt: ./txt/cord-029392-5s5686i9.txt cache: ./cache/cord-029392-5s5686i9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-029392-5s5686i9.txt' === file2bib.sh === id: cord-030131-klhg7x8z author: Tan, Dingyu title: High-flow nasal cannula oxygen therapy versus non-invasive ventilation for chronic obstructive pulmonary disease patients after extubation: a multicenter, randomized controlled trial date: 2020-08-06 pages: extension: .txt txt: ./txt/cord-030131-klhg7x8z.txt cache: ./cache/cord-030131-klhg7x8z.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-030131-klhg7x8z.txt' === file2bib.sh === id: cord-016042-iyuca9lv author: Keymel, Stefanie title: Noninvasive Mechanical Ventilation Guidelines and Standard Protocols for Noninvasive Mechanical Ventilation in Patients with High-Risk Infections date: 2013-05-29 pages: extension: .txt txt: ./txt/cord-016042-iyuca9lv.txt cache: ./cache/cord-016042-iyuca9lv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-016042-iyuca9lv.txt' === file2bib.sh === id: cord-002078-38rmx65j author: Korkmaz Ekren, Pervin title: Can fiberoptic bronchoscopy be applied to critically ill patients treated with noninvasive ventilation for acute respiratory distress syndrome? Prospective observational study date: 2016-05-31 pages: extension: .txt txt: ./txt/cord-002078-38rmx65j.txt cache: ./cache/cord-002078-38rmx65j.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-002078-38rmx65j.txt' === file2bib.sh === id: cord-000619-3bakci02 author: Zhang, Peng-jun title: Clinical features and risk factors for severe and critical pregnant women with 2009 pandemic H1N1 influenza infection in China date: 2012-02-01 pages: extension: .txt txt: ./txt/cord-000619-3bakci02.txt cache: ./cache/cord-000619-3bakci02.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-000619-3bakci02.txt' === file2bib.sh === id: cord-016416-h3cjylcl author: Javouhey, Etienne title: Pathophysiology of Acute Respiratory Failure in Children with Bronchiolitis and Effect of CPAP date: 2013-05-29 pages: extension: .txt txt: ./txt/cord-016416-h3cjylcl.txt cache: ./cache/cord-016416-h3cjylcl.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-016416-h3cjylcl.txt' === file2bib.sh === id: cord-000705-w52dc97h author: Ríos, Fernando G title: Lung Function and Organ Dysfunctions in 178 Patients Requiring Mechanical Ventilation During The 2009 Influenza A (H1N1) Pandemic date: 2011-08-17 pages: extension: .txt txt: ./txt/cord-000705-w52dc97h.txt cache: ./cache/cord-000705-w52dc97h.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-000705-w52dc97h.txt' === file2bib.sh === id: cord-009375-2hflah2h author: WANG, Xi-Jun title: Study of Fusion Protein and Attachment Glycoprotein of Nipah Virus Expressed in Recombinant Baculovirus date: 2006-06-15 pages: extension: .txt txt: ./txt/cord-009375-2hflah2h.txt cache: ./cache/cord-009375-2hflah2h.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-009375-2hflah2h.txt' === file2bib.sh === id: cord-017240-2vqehqfh author: Trindade e Silva, Luis Paulo title: Noninvasive Mechanical Ventilation for Hypoxemic Respiratory Failure-Related Infectious Diseases date: 2013-05-29 pages: extension: .txt txt: ./txt/cord-017240-2vqehqfh.txt cache: ./cache/cord-017240-2vqehqfh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-017240-2vqehqfh.txt' === file2bib.sh === id: cord-011269-j2rogzm7 author: Stefan, Mihaela S. title: Protocol for two-arm pragmatic cluster randomized hybrid implementation-effectiveness trial comparing two education strategies for improving the uptake of noninvasive ventilation in patients with severe COPD exacerbation date: 2020-05-06 pages: extension: .txt txt: ./txt/cord-011269-j2rogzm7.txt cache: ./cache/cord-011269-j2rogzm7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-011269-j2rogzm7.txt' === file2bib.sh === id: cord-016744-jzhuq4te author: Hui, David S. C. title: Noninvasive Mechanical Ventilation: Models to Assess Air and Particle Dispersion date: 2013-05-29 pages: extension: .txt txt: ./txt/cord-016744-jzhuq4te.txt cache: ./cache/cord-016744-jzhuq4te.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-016744-jzhuq4te.txt' === file2bib.sh === id: cord-017282-rahtmu3h author: Marvisi, Maurizio title: Pneumonia date: 2019-08-06 pages: extension: .txt txt: ./txt/cord-017282-rahtmu3h.txt cache: ./cache/cord-017282-rahtmu3h.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-017282-rahtmu3h.txt' === file2bib.sh === id: cord-014538-6a2pviol author: Kamilia, Chtara title: Proceedings of Réanimation 2017, the French Intensive Care Society International Congress date: 2017-01-10 pages: extension: .txt txt: ./txt/cord-014538-6a2pviol.txt cache: ./cache/cord-014538-6a2pviol.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-014538-6a2pviol.txt' === file2bib.sh === id: cord-016844-lq2bgu7a author: Teksam, Ozlem title: Noninvasive Mechanical Ventilation in Patients with High-Risk Infections and Mass Casualties in Acute Respiratory Failure: Pediatric Perspective date: 2013-05-29 pages: extension: .txt txt: ./txt/cord-016844-lq2bgu7a.txt cache: ./cache/cord-016844-lq2bgu7a.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-016844-lq2bgu7a.txt' === file2bib.sh === id: cord-011222-7aha5b07 author: Huang, Cheng-Chi title: The application of non-invasive and invasive mechanical ventilation in the first episode of acute respiratory failure date: 2020-03-30 pages: extension: .txt txt: ./txt/cord-011222-7aha5b07.txt cache: ./cache/cord-011222-7aha5b07.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-011222-7aha5b07.txt' === file2bib.sh === id: cord-034578-i9rdubix author: Vaschetto, Rosanna title: Outcomes of COVID-19 patients treated with continuous positive airway pressure outside ICU date: 2020-10-30 pages: extension: .txt txt: ./txt/cord-034578-i9rdubix.txt cache: ./cache/cord-034578-i9rdubix.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-034578-i9rdubix.txt' === file2bib.sh === id: cord-015548-zjrkfe9b author: Popat, Bhavesh title: Invasive and non-invasive mechanical ventilation date: 2012-05-18 pages: extension: .txt txt: ./txt/cord-015548-zjrkfe9b.txt cache: ./cache/cord-015548-zjrkfe9b.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-015548-zjrkfe9b.txt' === file2bib.sh === id: cord-010850-zj6k7wz9 author: Holbird, Samantha title: Noninvasive ventilation for pediatric interfacility transports: a retrospective study date: 2020-05-13 pages: extension: .txt txt: ./txt/cord-010850-zj6k7wz9.txt cache: ./cache/cord-010850-zj6k7wz9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-010850-zj6k7wz9.txt' === file2bib.sh === id: cord-017786-kfl6xt31 author: Curiel-Balsera, Emilio title: Guidelines for Health Organizations: European Perspectives and Experience in Pandemics date: 2013-05-29 pages: extension: .txt txt: ./txt/cord-017786-kfl6xt31.txt cache: ./cache/cord-017786-kfl6xt31.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-017786-kfl6xt31.txt' === file2bib.sh === id: cord-267537-akzydy7l author: Dang, Ha V. title: An antibody against the F glycoprotein inhibits Nipah and Hendra virus infections date: 2019-09-30 pages: extension: .txt txt: ./txt/cord-267537-akzydy7l.txt cache: ./cache/cord-267537-akzydy7l.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-267537-akzydy7l.txt' === file2bib.sh === id: cord-103020-ckuma42j author: McDowell, G. title: Two-way remote monitoring allows effective and realistic provision of home-NIV to COPD patients with persistent hypercapnia. date: 2020-11-12 pages: extension: .txt txt: ./txt/cord-103020-ckuma42j.txt cache: ./cache/cord-103020-ckuma42j.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-103020-ckuma42j.txt' === file2bib.sh === id: cord-260220-f1tpkw1o author: Timenetsky, Karina T title: High success and low mortality rates with non-invasive ventilation in influenza A H1N1 patients in a tertiary hospital date: 2011-09-28 pages: extension: .txt txt: ./txt/cord-260220-f1tpkw1o.txt cache: ./cache/cord-260220-f1tpkw1o.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-260220-f1tpkw1o.txt' === file2bib.sh === id: cord-034185-e0am7pa6 author: Piccioni, Federico title: Recommendations from the Italian intersociety consensus on Perioperative Anesthesa Care in Thoracic surgery (PACTS) part 2: intraoperative and postoperative care date: 2020-10-23 pages: extension: .txt txt: ./txt/cord-034185-e0am7pa6.txt cache: ./cache/cord-034185-e0am7pa6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-034185-e0am7pa6.txt' === file2bib.sh === id: cord-027526-ohcu28rk author: Zhou, Xiaoyang title: Preventive use of respiratory support after scheduled extubation in critically ill medical patients—a network meta-analysis of randomized controlled trials date: 2020-06-22 pages: extension: .txt txt: ./txt/cord-027526-ohcu28rk.txt cache: ./cache/cord-027526-ohcu28rk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-027526-ohcu28rk.txt' === file2bib.sh === id: cord-005727-li8pwigg author: nan title: ESICM 2010 MONDAY SESSIONS 11 October 2010 date: 2010-08-31 pages: extension: .txt txt: ./txt/cord-005727-li8pwigg.txt cache: ./cache/cord-005727-li8pwigg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 6 resourceName b'cord-005727-li8pwigg.txt' === file2bib.sh === id: cord-276238-2hv46ftk author: Ing, Richard J. title: The role of helmet-delivered noninvasive pressure support ventilation in COVID-19 patients date: 2020-05-08 pages: extension: .txt txt: ./txt/cord-276238-2hv46ftk.txt cache: ./cache/cord-276238-2hv46ftk.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-276238-2hv46ftk.txt' === file2bib.sh === id: cord-303292-iheq50ub author: De Jong, Audrey title: How to ventilate obese patients in the ICU date: 2020-10-23 pages: extension: .txt txt: ./txt/cord-303292-iheq50ub.txt cache: ./cache/cord-303292-iheq50ub.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-303292-iheq50ub.txt' === file2bib.sh === id: cord-293170-ir2y6sfz author: Lal, Tusharindra title: COVID-19 patients: when and whom to ventilate? date: 2020-08-19 pages: extension: .txt txt: ./txt/cord-293170-ir2y6sfz.txt cache: ./cache/cord-293170-ir2y6sfz.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-293170-ir2y6sfz.txt' === file2bib.sh === id: cord-313639-qpt47sx2 author: Zheng, Yi title: Clinical characteristics of 34 COVID-19 patients admitted to intensive care unit in Hangzhou, China date: 2020-05-20 pages: extension: .txt txt: ./txt/cord-313639-qpt47sx2.txt cache: ./cache/cord-313639-qpt47sx2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-313639-qpt47sx2.txt' === file2bib.sh === id: cord-309518-seonrtn3 author: Alraddadi, Basem M. title: Noninvasive ventilation in critically ill patients with the Middle East respiratory syndrome date: 2019-03-18 pages: extension: .txt txt: ./txt/cord-309518-seonrtn3.txt cache: ./cache/cord-309518-seonrtn3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-309518-seonrtn3.txt' === file2bib.sh === id: cord-330704-4piesfxu author: Avdeev, Sergey N. title: Noninvasive ventilation for acute hypoxemic respiratory failure in patients with COVID-19 date: 2020-10-01 pages: extension: .txt txt: ./txt/cord-330704-4piesfxu.txt cache: ./cache/cord-330704-4piesfxu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-330704-4piesfxu.txt' === file2bib.sh === id: cord-336690-ajmuaw10 author: McEnery, Tom title: COVID-19: Respiratory support outside the intensive care unit date: 2020-04-09 pages: extension: .txt txt: ./txt/cord-336690-ajmuaw10.txt cache: ./cache/cord-336690-ajmuaw10.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-336690-ajmuaw10.txt' === file2bib.sh === id: cord-313816-7d8x7fjp author: Cinesi Gómez, C. title: Clinical Consensus Recommendations Regarding Non-Invasive Respiratory Support in the Adult Patient with Acute Respiratory Failure Secondary to SARS-CoV-2 infection date: 2020-05-07 pages: extension: .txt txt: ./txt/cord-313816-7d8x7fjp.txt cache: ./cache/cord-313816-7d8x7fjp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-313816-7d8x7fjp.txt' === file2bib.sh === id: cord-027805-p0bhju1s author: Wong, An-Kwok Ian title: Consequences and Solutions for the Impact of Communication Impairment on Noninvasive Ventilation Therapy for Acute Respiratory Failure: A Focused Review date: 2020-06-15 pages: extension: .txt txt: ./txt/cord-027805-p0bhju1s.txt cache: ./cache/cord-027805-p0bhju1s.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 1 resourceName b'cord-027805-p0bhju1s.txt' === file2bib.sh === id: cord-352059-1bjskqyg author: Gupta, Nivedita title: Laboratory preparedness for SARS-CoV-2 testing in India: Harnessing a network of Virus Research & Diagnostic Laboratories date: 2020-04-28 pages: extension: .txt txt: ./txt/cord-352059-1bjskqyg.txt cache: ./cache/cord-352059-1bjskqyg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-352059-1bjskqyg.txt' === file2bib.sh === id: cord-290684-3f6prlqy author: Duan, Jun title: Use of high-flow nasal cannula and noninvasive ventilation in patients with COVID-19: A multicenter observational study date: 2020-07-29 pages: extension: .txt txt: ./txt/cord-290684-3f6prlqy.txt cache: ./cache/cord-290684-3f6prlqy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-290684-3f6prlqy.txt' === file2bib.sh === id: cord-352850-as12ll8s author: Wang, Tao title: Clinical Features of Coronavirus Disease 2019 Patients With Mechanical Ventilation: A Nationwide Study in China date: 2020-06-23 pages: extension: .txt txt: ./txt/cord-352850-as12ll8s.txt cache: ./cache/cord-352850-as12ll8s.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 1 resourceName b'cord-352850-as12ll8s.txt' === file2bib.sh === id: cord-335078-z7k59k8o author: Burton-Papp, Helmi C. title: Conscious prone positioning during non-invasive ventilation in COVID-19 patients: experience from a single centre date: 2020-07-31 pages: extension: .txt txt: ./txt/cord-335078-z7k59k8o.txt cache: ./cache/cord-335078-z7k59k8o.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-335078-z7k59k8o.txt' === file2bib.sh === id: cord-327622-ezgufe24 author: Kaur, Ramandeep title: Practical strategies to reduce nosocomial transmission to healthcare professionals providing respiratory care to patients with COVID-19 date: 2020-09-23 pages: extension: .txt txt: ./txt/cord-327622-ezgufe24.txt cache: ./cache/cord-327622-ezgufe24.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-327622-ezgufe24.txt' === file2bib.sh === id: cord-344641-rog2h4g7 author: Franco, Cosimo title: Feasibility and clinical impact of out-of-ICU non-invasive respiratory support in patients with COVID-19 related pneumonia date: 2020-08-03 pages: extension: .txt txt: ./txt/cord-344641-rog2h4g7.txt cache: ./cache/cord-344641-rog2h4g7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-344641-rog2h4g7.txt' === file2bib.sh === id: cord-354330-pud2rqxk author: Pirzada, Abdul Rouf title: Management of Aerosol during Noninvasive Ventilation for Patients with Sleep-Disordered Breathing: Important Messages during the COVID-19 Pandemic date: 2020-06-17 pages: extension: .txt txt: ./txt/cord-354330-pud2rqxk.txt cache: ./cache/cord-354330-pud2rqxk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-354330-pud2rqxk.txt' === file2bib.sh === id: cord-355450-v3eh1rtk author: Boattini, Matteo title: Influenza and respiratory syncytial virus infections in the oldest-old continent date: 2020-06-27 pages: extension: .txt txt: ./txt/cord-355450-v3eh1rtk.txt cache: ./cache/cord-355450-v3eh1rtk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-355450-v3eh1rtk.txt' === file2bib.sh === id: cord-312864-km07zhn1 author: Potalivo, A. title: Sixty-day mortality among 520 Italian hospitalized COVID-19 patients according to the adopted ventilatory strategy in the context of an integrated multidisciplinary clinical organization: a population-based cohort study date: 2020-08-15 pages: extension: .txt txt: ./txt/cord-312864-km07zhn1.txt cache: ./cache/cord-312864-km07zhn1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 1 resourceName b'cord-312864-km07zhn1.txt' === file2bib.sh === id: cord-335975-m6lkrehi author: nan title: Proceedings of Réanimation 2018, the French Intensive Care Society International Congress date: 2018-02-05 pages: extension: .txt txt: ./txt/cord-335975-m6lkrehi.txt cache: ./cache/cord-335975-m6lkrehi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 6 resourceName b'cord-335975-m6lkrehi.txt' === file2bib.sh === id: cord-352577-h3652seb author: Kopić, Jasminka title: Expanding the Use of Noninvasive Ventilation During an Epidemic date: 2014-08-27 pages: extension: .txt txt: ./txt/cord-352577-h3652seb.txt cache: ./cache/cord-352577-h3652seb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-352577-h3652seb.txt' === file2bib.sh === id: cord-010669-rg2p3kal author: Fubini, PE title: Prehospital reversal of profound respiratory acidosis and hypercapnic coma by non-invasive ventilation: a report of two cases date: 2020-05-07 pages: extension: .txt txt: ./txt/cord-010669-rg2p3kal.txt cache: ./cache/cord-010669-rg2p3kal.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-010669-rg2p3kal.txt' === file2bib.sh === id: cord-268049-7xqln70d author: Montrief, Tim title: COVID-19 respiratory support in the emergency department setting date: 2020-08-08 pages: extension: .txt txt: ./txt/cord-268049-7xqln70d.txt cache: ./cache/cord-268049-7xqln70d.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-268049-7xqln70d.txt' === file2bib.sh === /data-disk/reader-compute/reader-cord/bin/file2bib.sh: fork: retry: No child processes id: cord-355038-o2hr5mox author: nan title: Proceedings of Réanimation 2020, the French Intensive Care Society International Congress date: 2020-02-11 pages: extension: .txt txt: ./txt/cord-355038-o2hr5mox.txt cache: ./cache/cord-355038-o2hr5mox.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 10 resourceName b'cord-355038-o2hr5mox.txt' === file2bib.sh === id: cord-013149-y0dbhtef author: Wohlfarth, P. title: Hämatoonkologie und Intensivmedizin: Vom Tabu zur Conditio sine qua non date: 2020-10-12 pages: extension: .txt txt: ./txt/cord-013149-y0dbhtef.txt cache: ./cache/cord-013149-y0dbhtef.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-013149-y0dbhtef.txt' === file2bib.sh === id: cord-346565-vsgbmxzv author: Cascella, Marco title: Rapid and Impressive Response to a Combined Treatment with Single-Dose Tocilizumab and NIV in a Patient with COVID-19 Pneumonia/ARDS date: 2020-07-27 pages: extension: .txt txt: ./txt/cord-346565-vsgbmxzv.txt cache: ./cache/cord-346565-vsgbmxzv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-346565-vsgbmxzv.txt' === file2bib.sh === id: cord-016897-t71f10kv author: Flores, Marco V. title: Preventing Airborne Disease Transmission: Implications for Patients During Mechanical Ventilation date: 2013-05-29 pages: extension: .txt txt: ./txt/cord-016897-t71f10kv.txt cache: ./cache/cord-016897-t71f10kv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-016897-t71f10kv.txt' Que is empty; done keyword-niv-cord === reduce.pl bib === id = cord-029392-5s5686i9 author = Zayed, Yazan title = Effect of oxygenation modalities among patients with postoperative respiratory failure: a pairwise and network meta-analysis of randomized controlled trials date = 2020-07-17 pages = extension = .txt mime = text/plain words = 3974 sentences = 215 flesch = 36 summary = Our aim is to compare outcomes between non-invasive ventilation (NIV), high-flow nasal cannula (HFNC), and standard oxygen in patients at high-risk for or with established postoperative respiratory failure. We included only randomized controlled trials (RCTs) that compared NIV, HFNC, and standard oxygen in patients at high risk for or with established postoperative respiratory failure. CONCLUSIONS: Among patients with post-operative respiratory failure, HFNC and NIV were associated with significantly reduced rates of intubation and ICU-acquired infections compared with standard oxygen. In this first network meta-analysis comparing various oxygenation strategies in patients at risk for hypoxemic respiratory failure or established respiratory failure within 7 days of surgery, we have found that NIV and HFNC were associated with a significant reduction in intubation rates and ICU-acquired infections when compared to standard oxygen therapy. cache = ./cache/cord-029392-5s5686i9.txt txt = ./txt/cord-029392-5s5686i9.txt === reduce.pl bib === id = cord-030131-klhg7x8z author = Tan, Dingyu title = High-flow nasal cannula oxygen therapy versus non-invasive ventilation for chronic obstructive pulmonary disease patients after extubation: a multicenter, randomized controlled trial date = 2020-08-06 pages = extension = .txt mime = text/plain words = 4583 sentences = 200 flesch = 45 summary = title: High-flow nasal cannula oxygen therapy versus non-invasive ventilation for chronic obstructive pulmonary disease patients after extubation: a multicenter, randomized controlled trial This study was conducted to test if HFNC is non-inferior to non-invasive ventilation (NIV) in preventing post-extubation treatment failure in COPD patients previously intubated for hypercapnic respiratory failure. METHODS: COPD patients with hypercapnic respiratory failure who were already receiving invasive ventilation were randomized to HFNC or NIV at extubation at two large tertiary academic teaching hospitals. CONCLUSION: Among COPD patients with severe hypercapnic respiratory failure who received invasive ventilation, the use of HFNC after extubation did not result in increased rates of treatment failure compared with NIV. Among COPD patients with severe hypercapnic respiratory failure who received invasive ventilation, the use of HFNC as compared with NIV after extubation did not result in increased rates of treatment failure, while HFNC had better tolerance and comfort. cache = ./cache/cord-030131-klhg7x8z.txt txt = ./txt/cord-030131-klhg7x8z.txt === reduce.pl bib === id = cord-016042-iyuca9lv author = Keymel, Stefanie title = Noninvasive Mechanical Ventilation Guidelines and Standard Protocols for Noninvasive Mechanical Ventilation in Patients with High-Risk Infections date = 2013-05-29 pages = extension = .txt mime = text/plain words = 1665 sentences = 97 flesch = 44 summary = Noninvasive ventilation (NIV) is associated with lower rates of endotracheal intubation and decreased mortality in patients with acute respiratory failure. With endemic and high-risk infection, most of the critically ill patients develop acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS). A year later, the British Thoracic Society (BTS) published guidelines on the use of NIV in patients with acute respiratory failure (ARF). The Canadian Critical Care Trials group made no recommendations about the use of NIV in ARDS patients or those with severe community-acquired pneumonia (CAP) in 2011 [ 5 ] . • Current guidelines do not recommend NIV for the treatment of hypoxemic respiratory failure in endemic and pandemic infections (e.g., SARS or H1N1). International consensus conference in intensive care medicine: noninvasive positive pressure ventilation in acute respiratory failure Noninvasive positive pressure ventilation treatment for acute respiratory failure in SARS cache = ./cache/cord-016042-iyuca9lv.txt txt = ./txt/cord-016042-iyuca9lv.txt === reduce.pl bib === id = cord-002078-38rmx65j author = Korkmaz Ekren, Pervin title = Can fiberoptic bronchoscopy be applied to critically ill patients treated with noninvasive ventilation for acute respiratory distress syndrome? Prospective observational study date = 2016-05-31 pages = extension = .txt mime = text/plain words = 3579 sentences = 253 flesch = 45 summary = title: Can fiberoptic bronchoscopy be applied to critically ill patients treated with noninvasive ventilation for acute respiratory distress syndrome? The primary outcome of this prospective observational study was to evaluate the feasibility, safety and contribution in diagnosis and/or modification of the ongoing treatment of fiberoptic bronchoscopy (FOB) in patients with ARDS treated with NIV. METHODS: ARDS patients treated with NIV and who require FOB as the diagnostic or therapeutic procedure were included the study. Fiberoptic bronchoscopy (FOB) may be required in some patients with acute respiratory failure in intensive care units (ICU), mainly as diagnostic tool or to remove abundant secretions [7, 8] . Abbreviations APACHE II: Acute Physiology and Chronic Health Evaluation II; ARDS: acute respiratory distress syndrome; BAL: bronchoalveolar lavage; COPD: chronic obstructive pulmonary disease; EPAP: expiratory positive airway pressures; FOB: fiberoptic bronchoscopy; ICU: intensive care unit; IPAP: inspiratory positive airway pressure; NIV: noninvasive ventilation; PEEP: positive end expiratory pressure. cache = ./cache/cord-002078-38rmx65j.txt txt = ./txt/cord-002078-38rmx65j.txt === reduce.pl bib === id = cord-000619-3bakci02 author = Zhang, Peng-jun title = Clinical features and risk factors for severe and critical pregnant women with 2009 pandemic H1N1 influenza infection in China date = 2012-02-01 pages = extension = .txt mime = text/plain words = 3110 sentences = 212 flesch = 55 summary = title: Clinical features and risk factors for severe and critical pregnant women with 2009 pandemic H1N1 influenza infection in China Data on risk factors associated with death of pregnant women and neonates with pH1N1 infections are limited outside of developed countries. METHODS: Retrospective observational study in 394 severe or critical pregnant women admitted to a hospital with pH1N1 influenza from Sep. 1, 2009 to Dec. 31, 2009. Preterm delivery was a risk factor for neonatal death among pregnant women with pH1N1 influenza infection. However, information is limited concerning the risk factors for maternal and neonatal death when pregnancy is complicated by severe or critical illness related to 2009 pH1N1 influenza. In this report, we described the characteristics of pH1N1 influenza in pregnant women and the risk factors for maternal and neonatal death. The clinical data reported herein is consistent with previous studies that demonstrate that pregnant women with influenza are at an increased risk of serious illness and death. cache = ./cache/cord-000619-3bakci02.txt txt = ./txt/cord-000619-3bakci02.txt === reduce.pl bib === id = cord-016416-h3cjylcl author = Javouhey, Etienne title = Pathophysiology of Acute Respiratory Failure in Children with Bronchiolitis and Effect of CPAP date = 2013-05-29 pages = extension = .txt mime = text/plain words = 5576 sentences = 316 flesch = 55 summary = Curiously, blood gas analyses have not been found to be good indicators of ventilatory support requirement except in the study of Campion et al., where a high level of CO 2 before CPAP was predictive of NIV failure defi ned as the need for invasive ventilation [ 8 ] . Liet and colleagues reported three cases of infants with severe bronchiolitis treated with this mode during invasive mechanical ventilation and showed that NAVA was able to improve synchrony, decrease the oxygen requirement, and decrease peak airway pressure from 28 ± 3 to 15 ± 5 cmH 2 O [ 33 ] . Moreover, as no study has been performed on NIV at two pressure levels in bronchiolitis, there is no evidence that NIV after CPAP or HFC failure can obviate the need for intubation and invasive ventilation. cache = ./cache/cord-016416-h3cjylcl.txt txt = ./txt/cord-016416-h3cjylcl.txt === reduce.pl bib === id = cord-000705-w52dc97h author = Ríos, Fernando G title = Lung Function and Organ Dysfunctions in 178 Patients Requiring Mechanical Ventilation During The 2009 Influenza A (H1N1) Pandemic date = 2011-08-17 pages = extension = .txt mime = text/plain words = 4859 sentences = 301 flesch = 48 summary = METHOD: This was a multicenter, prospective inception cohort study including adult patients with acute respiratory failure requiring mechanical ventilation (MV) admitted to 20 ICUs in Argentina between June and September of 2009 during the influenza A (H1N1) pandemic. Although a mild form of the disease was prevalent, it soon became evident that the 2009 influenza A (H1N1) virus could also provoke severe, acute respiratory failure requiring admission to the intensive care unit (ICU) for mechanical ventilation [16] , which was reflected in the severe pathological injury found at autopsy [17] . This was a multicenter, inception cohort study that included patients aged > 15 years admitted to the ICU with a previous history of influenza-like illness, evolving to acute respiratory failure that required mechanical ventilation during the 2009 winter in the Southern Hemisphere. We report on a large, prospective cohort of 2009 influenza A (H1N1) patients that were mechanically ventilated for acute respiratory failure due to diffuse pneumonitis during the pandemic in Argentina. cache = ./cache/cord-000705-w52dc97h.txt txt = ./txt/cord-000705-w52dc97h.txt === reduce.pl bib === id = cord-009375-2hflah2h author = WANG, Xi-Jun title = Study of Fusion Protein and Attachment Glycoprotein of Nipah Virus Expressed in Recombinant Baculovirus date = 2006-06-15 pages = extension = .txt mime = text/plain words = 4482 sentences = 194 flesch = 47 summary = The envelope attachment glycoprotein (G) and fusion protein (F′) of Nipah virus (NiV) play a key role in viral entry and induction of neutralization antibody. Furthermore, the G and F protein-specific antibodies could neutralize the infectivity of the VSVΔG*F/G, the NiV F and G-envelope glycoproteins of pseudotype recombinant Vesicular Stomatitis Virus expressing green fluorescence protein. Furthermore, the G and F protein-specific antibodies could neutralize the infectivity of the VSVΔG*F/G, the NiV F and G-envelope glycoproteins of pseudotype recombinant Vesicular Stomatitis Virus expressing green fluorescence protein. For detecting reactionogenicity of rNF and rNG expressed by the recombinant baculoviruses, ELISA plates were coated with the lysate of sf9 cells that were infected by rBac-NiV-F and rBac-NiV-G and detected with 1:200 dilution of polyclone serum from rabbits immunized with inactivated NiV (kindly provided by Dr. L. In this study, immunization with insect cells was infected by the recombinant baculoviruses, thereby expressing NiV G and F proteins, eliciting G and F protein-specific antibody responses in mice. cache = ./cache/cord-009375-2hflah2h.txt txt = ./txt/cord-009375-2hflah2h.txt === reduce.pl bib === id = cord-017240-2vqehqfh author = Trindade e Silva, Luis Paulo title = Noninvasive Mechanical Ventilation for Hypoxemic Respiratory Failure-Related Infectious Diseases date = 2013-05-29 pages = extension = .txt mime = text/plain words = 2944 sentences = 159 flesch = 51 summary = • Evidence level 2-derived from systematic reviews with homogeneity of cohort studies, individual cohorts, and/or poor-quality RCTs. NIV is applied in patients with a "do not intubate" order, as a palliative measure in terminally ill patients, to prevent extubation failure in patients with COPD or heart failure, for communityacquired pneumonia (CAP) in COPD patients, to prevent and treat postoperative respiratory failure, and to prevent ARF due to asthma. [ 2 ] , which included eight RCTs that had studied patients with AHRF secondary to causes other than ACPO, the NIV reduced the ETI rate by 23 %, the length of stay in the intensive care unit (ICU) by 2 days, and ICU mortality by 17 % (absolute risk reduction). [ 8 ] , in a prospective observational study, compared the effi cacy of NIV in patients without COPD but with hypoxemic respiratory failure due to ACPO (15 patients) or severe CAP (18 patients). cache = ./cache/cord-017240-2vqehqfh.txt txt = ./txt/cord-017240-2vqehqfh.txt === reduce.pl bib === id = cord-011269-j2rogzm7 author = Stefan, Mihaela S. title = Protocol for two-arm pragmatic cluster randomized hybrid implementation-effectiveness trial comparing two education strategies for improving the uptake of noninvasive ventilation in patients with severe COPD exacerbation date = 2020-05-06 pages = extension = .txt mime = text/plain words = 7383 sentences = 335 flesch = 39 summary = title: Protocol for two-arm pragmatic cluster randomized hybrid implementation-effectiveness trial comparing two education strategies for improving the uptake of noninvasive ventilation in patients with severe COPD exacerbation Through a series of mixed-methods studies, we have found that successful implementation of NIV requires physicians, respiratory therapists (RTs), and nurses to communicate and collaborate effectively, suggesting that efforts to increase the use of NIV in COPD need to account for the complex and interdisciplinary nature of NIV delivery and the need for team coordination. The overall objective of this study is to conduct a pragmatic, parallel, 2-arm randomized cluster trial to compare the effectiveness of two implementation strategies: on-line education (OLE) and interprofessional education (IPE) on the uptake of NIV. Hospitals that demonstrate interest in participating in the study will be asked to commit to form a COPD-NIV team composed of one physician, one RT, and one nurse that will be in close contact with the investigators and are responsible for delivering the educational intervention in their institution. cache = ./cache/cord-011269-j2rogzm7.txt txt = ./txt/cord-011269-j2rogzm7.txt === reduce.pl bib === id = cord-016744-jzhuq4te author = Hui, David S. C. title = Noninvasive Mechanical Ventilation: Models to Assess Air and Particle Dispersion date = 2013-05-29 pages = extension = .txt mime = text/plain words = 3687 sentences = 166 flesch = 49 summary = particles generated during tidal breathing [ 8 ] , NIV may disperse potentially infected aerosols, especially when patients cough and sneeze frequently, contributing to nosocomial transmission of infl uenza. As there is no reliable, safe marker that can be introduced into human lungs for experimental purposes, the laser smoke visualization method and the human patient simulator (HPS) model have been adopted as the method for studying exhaled air dispersion during application of various types of respiratory therapy in hospital medical wards, including the negative-pressure isolation room [ 10 -13 ] . Sections through the leakage jet plume were then revealed by a thin, green laser light sheet (532 nm wavelength, continuous-wave A laser beam located on the right side of the bed lateral to the human patient simulator illuminates the exhaled air particles leaking from the exhalation ports of the face mask in the coronal plane. cache = ./cache/cord-016744-jzhuq4te.txt txt = ./txt/cord-016744-jzhuq4te.txt === reduce.pl bib === id = cord-017282-rahtmu3h author = Marvisi, Maurizio title = Pneumonia date = 2019-08-06 pages = extension = .txt mime = text/plain words = 2532 sentences = 131 flesch = 40 summary = All patients with CAP should receive oxygen treatment as needed with the aim of maintaining an arterial oxygen saturation (SpO 2 ) of 92% corresponding to a partial pressure of oxygen in the blood of about 60 mmHg. Lower values are accepted in cases of underlying severe pulmonary disease with a risk of carbon dioxide retention. While the clinical practice guidelines on evidence-based application of NIV for community-acquired pneumonia did not provide a recommendation for its use, the Infectious Disease Society of America/American Thoracic Society guidelines on management of CAP did suggest a cautious trial of NIV [2, 12] . Most studies on NIV and treatment of acute hypoxemic respiratory failure, including CAP, have been carried out in the critical care setting and have reported controversial results with varying failure rates for NIV use. Effect of noninvasive ventilation vs oxygen therapy on mortality among immunocompromised patients with acute respiratory failure: a randomized clinical trial Effectiveness of high-flow nasal cannula oxygen therapy for acute respiratory failure with hypercapnia cache = ./cache/cord-017282-rahtmu3h.txt txt = ./txt/cord-017282-rahtmu3h.txt === reduce.pl bib === id = cord-014538-6a2pviol author = Kamilia, Chtara title = Proceedings of Réanimation 2017, the French Intensive Care Society International Congress date = 2017-01-10 pages = extension = .txt mime = text/plain words = 61068 sentences = 3463 flesch = 49 summary = Other parameters that were significantly different between the patients who died and those who survived were an advanced age, an elevated IGS II score at hospital admission, an elevated SOFA score at study entry, a late healthcare-associated infection and several biological variables: a high C reactive protein, low albumin and prealbumin and a poor percent of monocytes expressing HLA-DR, all measured at day 7. Parameters collected were demographic features, comorbidities, regular treatment, dyspnea assessed by the MRC scale, initial clinical severity reflected by SAPS II and APACHE II scores, modalities and ICU admission deadlines, initial arterial blood gas analysis, management of patients in the ICU (ventilation modalities, prescription of antibiotics, use of vasoactive drugs) and their outcomes (incidence of nosocomial infections and their sites, length of stay and ICU mortality). cache = ./cache/cord-014538-6a2pviol.txt txt = ./txt/cord-014538-6a2pviol.txt === reduce.pl bib === id = cord-016844-lq2bgu7a author = Teksam, Ozlem title = Noninvasive Mechanical Ventilation in Patients with High-Risk Infections and Mass Casualties in Acute Respiratory Failure: Pediatric Perspective date = 2013-05-29 pages = extension = .txt mime = text/plain words = 3932 sentences = 206 flesch = 45 summary = title: Noninvasive Mechanical Ventilation in Patients with High-Risk Infections and Mass Casualties in Acute Respiratory Failure: Pediatric Perspective Invasive mechanical ventilation (IMV) is a critical intervention in many cases of acute respiratory failure (ARF), but there are absolute risks associated with endotracheal intubation (ETI). Additionally, the World Health Organization's interim guidelines on the prevention and control of acute respiratory diseases associated with health care have included NIV among the aerosol-generating procedures in which there is possibly an increased risk of respiratory pathogen transmission [ 11 ] . Nonetheless, after the most important two viral pandemics during the last decade, especially the last one with infl uenza A(H1N1), most of the societies including above-mentioned and the European Respiratory Society, European Society of Intensive Care Medicine, and The American Association for Respiratory Care have recommended that NIV not be used to treat ARF due to H1N1, particularly in severely ill patients. cache = ./cache/cord-016844-lq2bgu7a.txt txt = ./txt/cord-016844-lq2bgu7a.txt === reduce.pl bib === id = cord-011222-7aha5b07 author = Huang, Cheng-Chi title = The application of non-invasive and invasive mechanical ventilation in the first episode of acute respiratory failure date = 2020-03-30 pages = extension = .txt mime = text/plain words = 3398 sentences = 163 flesch = 49 summary = NIV use was frequently observed in old-age persons (aOR 3.99, 95% CI 3.06–5.21 for those aged ≥ 80 years), women (aOR 1.33, 95% CI 1.18–1.50), patients admitted to a high-level hospital (aOR 1.95, 95% CI 1.63−2.34 for those admitted to a medical center), and patients with a higher Charlson comorbidity index (CCI, aOR 1.38−1.66 for those CCI ≥ 2). In addition, patients with chronic pulmonary disease, cancer, and congestive heart failure were predominant in NIV users and were significantly associated with NIV use. Patients comorbid with a medical history of cancer (aOR 2.57, 95% CI 2.23−2.97), chronic pulmonary disease (aOR 2.24, 95% CI 1.97−2.55), and congestive heart failure (aOR 1.27, 95% CI 1.08−1.49) had a significantly higher NIV choice compared to that of individuals without those medical history. cache = ./cache/cord-011222-7aha5b07.txt txt = ./txt/cord-011222-7aha5b07.txt === reduce.pl bib === id = cord-034578-i9rdubix author = Vaschetto, Rosanna title = Outcomes of COVID-19 patients treated with continuous positive airway pressure outside ICU date = 2020-10-30 pages = extension = .txt mime = text/plain words = 3678 sentences = 206 flesch = 46 summary = AIM: We aim at characterising a large population of Coronavirus 19 (COVID-19) patients with moderate-to-severe hypoxemic acute respiratory failure (ARF) receiving CPAP outside intensive care unit (ICU), and ascertaining whether the duration of CPAP application increased the risk of mortality for patients requiring intubation. We designed this retrospective multicentre study to describe the clinical characteristics of patients with laboratory-confirmed COVID-19 treated with CPAP outside ICU, to assess 60-day in-hospital mortality, and hospital length of stay (LOS), and to ascertain whether the duration CPAP application prior to CPAP failure affects outcome in patients requiring endotracheal intubation. This multicentre retrospective observational study on 537 patients hypoxemic ARF secondary to laboratory-confirmed COVID-19 infection, shows that CPAP applied to different therapeutic goals i.e., candidate to intubation in the case of CPAP failure and do-not-intubate in which CPAP is considered the ceiling of treatment, is feasible outside ICU. cache = ./cache/cord-034578-i9rdubix.txt txt = ./txt/cord-034578-i9rdubix.txt === reduce.pl bib === id = cord-015548-zjrkfe9b author = Popat, Bhavesh title = Invasive and non-invasive mechanical ventilation date = 2012-05-18 pages = extension = .txt mime = text/plain words = 3044 sentences = 149 flesch = 32 summary = Early use of non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary disease on general respiratory wards: a multicentre randomised controlled trial Clinical practice guideline for the use of noninvasive positive pressure ventilation in COPD patients with acute respiratory failure Non-invasive positive pressure ventilation to treat respiratory failure resulting from exacerbations of chronic obstructive pulmonary disease: cochrane systematic review and meta-analysis Non-invasive positive pressure ventilation for treatment of respiratory failure due to exacerbations of chronic obstructive pulmonary disease. Randomised controlled comparison of continuous positive airways pressure, bilevel non-invasive ventilation, and standard treatment in emergency department patients with acute cardiogenic pulmonary oedema Non-invasive pressure support ventilation versus conventional oxygen therapy in acute cardiogenic pulmonary oedema: a randomised trial The evidence for noninvasive positive-pressure ventilation in the care of patients in acute respiratory failure: a systematic review of the literature Non-invasive positive pressure ventilation for treatment of respiratory failure due to severe acute exacerbations of asthma cache = ./cache/cord-015548-zjrkfe9b.txt txt = ./txt/cord-015548-zjrkfe9b.txt === reduce.pl bib === id = cord-010850-zj6k7wz9 author = Holbird, Samantha title = Noninvasive ventilation for pediatric interfacility transports: a retrospective study date = 2020-05-13 pages = extension = .txt mime = text/plain words = 1978 sentences = 113 flesch = 45 summary = BACKGROUND: To characterize pediatric patients supported with continuous positive airway pressure and bilevel positive airway pressure (CPAP/BiPAP) or high-flow nasal cannula (HFNC) during interfacility transport (IFT). Pediatric patients aged 28 days to < 17 years, who required IFT between January 2017 and December 2018, were identified through a transport registry and were included in the study. The objectives of this retrospective chart review study were to characterize pediatric patients requiring IFTs and NIV and to examine their clinical outcomes, including the need for airway instrumentation. A total of 120 patients (Table 1 ) on NIV or HFNC for IFT were studied (26.7% of transport cohort), but 2 had incomplete records and were excluded from analysis. Our crude IFT data showed that in 2019, 62% of patients requiring respiratory support were initiated on NIV; in 2014, it was less than 10%. cache = ./cache/cord-010850-zj6k7wz9.txt txt = ./txt/cord-010850-zj6k7wz9.txt === reduce.pl bib === id = cord-017786-kfl6xt31 author = Curiel-Balsera, Emilio title = Guidelines for Health Organizations: European Perspectives and Experience in Pandemics date = 2013-05-29 pages = extension = .txt mime = text/plain words = 1648 sentences = 93 flesch = 43 summary = Recommendations for droplets include patient isolation with protective measures for health care providers and other patients, use of double-circuit tubes and special fi lters for nonrebreathing devices, minimization of leaks, preferably fullface mask or helmet interfaces, avoidance of heated humidifi ers, and disposing of mask and tubes after use according to routine infection control procedures [ 7 ] . The document states that: …noninvasive mechanical ventilation cannot be considered a technique of choice in patients with acute respiratory distress syndrome, but could be useful in experienced centers and in cases of respiratory failure associated with exacerbation of chronic obstructive pulmonary disease or heart failure. • Noninvasive mechanical ventilation cannot be considered a technique of choice in patients with ARDS but could be useful in experienced centers and in cases of respiratory failure associated with exacerbation of chronic obstructive pulmonary disease or heart failure. cache = ./cache/cord-017786-kfl6xt31.txt txt = ./txt/cord-017786-kfl6xt31.txt === reduce.pl bib === id = cord-267537-akzydy7l author = Dang, Ha V. title = An antibody against the F glycoprotein inhibits Nipah and Hendra virus infections date = 2019-09-30 pages = extension = .txt mime = text/plain words = 9566 sentences = 545 flesch = 52 summary = Cryo-electron microscopy, triggering and fusion studies show the antibody binds to a prefusion-specific quaternary epitope, conserved in NiV F and HeV F glycoproteins, and prevents membrane fusion and viral entry. To elucidate the mechanism of 5B3-mediated neutralization of NiV and HeV, we determined a cryo-EM structure of a stabilized NiV F ectodomain trimer in complex with the 5B3 antibody Fab fragment at 3.5 Å resolution (Fig. 2a,b , Table 1 and Extended Data 1). To further study the mechanism of action of 5B3/h5B3.1 in the context of a full-length, membrane-embedded F glycoprotein, we carried out cell-cell fusion assays in the presence of varying concentrations of mAbs. We observed that 5B3 and h5B3.1 prevented NiV F-and HeV F-mediated membrane fusion in a concentration-dependent manner, consistent with the expectation that trapping F in the prefusion conformation actually resulted in inhibition of membrane fusion (Figs. cache = ./cache/cord-267537-akzydy7l.txt txt = ./txt/cord-267537-akzydy7l.txt === reduce.pl bib === id = cord-103020-ckuma42j author = McDowell, G. title = Two-way remote monitoring allows effective and realistic provision of home-NIV to COPD patients with persistent hypercapnia. date = 2020-11-12 pages = extension = .txt mime = text/plain words = 5817 sentences = 316 flesch = 48 summary = Background Outcomes for chronic obstructive pulmonary disease (COPD) patients with persistent hypercapnic respiratory failure are improved by long-term home non-invasive ventilation (NIV). The primary outcome of this study was time to readmission or death at 12 months in patients receiving home-NIV versus a retrospectively identified control cohort of 27 patients with hypercapnic COPD who had not been referred for home-NIV. The present study retrospectively analysed all patients who were commenced on therapy over the first 12 months of this service, with aim of determining whether outcomes similar to RCTs were achieved in a real-world cohort of hypercapnic COPD patients with typical comorbidities (which would have excluded many from NIV RCTs) who are managed with remote-monitored home NIV. Changes in healthcare usage (number of hospital admissions, OBDs, and respiratory nurse home visits) and capillary blood gas PCO 2 and bicarbonate between NIV users, NIV non-users and the control cohort were analysed using Wilcoxon signed-rank test. cache = ./cache/cord-103020-ckuma42j.txt txt = ./txt/cord-103020-ckuma42j.txt === reduce.pl bib === id = cord-260220-f1tpkw1o author = Timenetsky, Karina T title = High success and low mortality rates with non-invasive ventilation in influenza A H1N1 patients in a tertiary hospital date = 2011-09-28 pages = extension = .txt mime = text/plain words = 3463 sentences = 189 flesch = 54 summary = In this study we describe the respiratory profile, the mortality rate, and the benefit of using NIV in patients with confirmed diagnosis of influenza AH1N1 who were admitted in the ICU during the year 2009. To confirm the cases of swine-origin influenza A H1N1 virus by real-time RT-PCR (RT-RTPCR), nasopharyngeal-swab samples were collected at hospital admission and respiratory secretions obtained from intubated patients. Noninvasive mechanical ventilation was instituted in the confirmed influenza A H1N1 when there were signs of acute respiratory failure at hospital admission or during ICU stay. Patients that were admitted with signs of acute respiratory failure as described above, with extreme levels of hypoxemia (PaO2 lower than 60 mmHg with a high oxygen concentration delivered by a mask with a non re-breathing system -100%), low level of consciousness, or refuse to use NIV were promptly intubated at ICU admission. cache = ./cache/cord-260220-f1tpkw1o.txt txt = ./txt/cord-260220-f1tpkw1o.txt === reduce.pl bib === id = cord-034185-e0am7pa6 author = Piccioni, Federico title = Recommendations from the Italian intersociety consensus on Perioperative Anesthesa Care in Thoracic surgery (PACTS) part 2: intraoperative and postoperative care date = 2020-10-23 pages = extension = .txt mime = text/plain words = 18220 sentences = 941 flesch = 37 summary = We do not recommend the routine use of either continuous positive airway pressure (CPAP) or non invasive ventilation (NIV) to prevent postoperative pulmonary complications, prolonged length of stay, and mortality (both in ICU and in hospital) in patients undergoing major thoracic surgery. Level of evidence: Fair Strength of recommendation: C A meta-analysis of 45 studies including almost 5800 patients showed that a single perioperative dose of intravenous dexamethasone resulted in significant reductions in pain scores and opioid use, and was associated with shorter stays in the post-anesthesia recovery room, compared with placebo or antiemetic treatment (Waldron et al. Level of evidence: Fair Strength of recommendation: A Multiple clinical trials have shown that, in patients undergoing open thoracotomy or other major surgical procedures, thoracic epidural analgesia (TEA) is superior to intravenous opioid administration in terms of postoperative pain relief, length of hospital stay, and incidence of postoperative complications (Hazelrigg et al. cache = ./cache/cord-034185-e0am7pa6.txt txt = ./txt/cord-034185-e0am7pa6.txt === reduce.pl bib === id = cord-027526-ohcu28rk author = Zhou, Xiaoyang title = Preventive use of respiratory support after scheduled extubation in critically ill medical patients—a network meta-analysis of randomized controlled trials date = 2020-06-22 pages = extension = .txt mime = text/plain words = 6436 sentences = 329 flesch = 44 summary = METHODS: A systematic database search was performed from inception to December 19, 2019, for randomized controlled trials (RCTs) that compared a preventive use of different respiratory support methods, including conventional oxygen therapy (COT), noninvasive ventilation (NIV), high-flow oxygen therapy (HFOT), and combinational use of HFOT and NIV (HFOT+NIV), after planned extubation in adult critically ill medical patients. Nevertheless, the latest meta-analysis [19] of randomized controlled trials (RCTs) suggested that compared to COT, preventive use of NIV after extubation had no effect on the re-intubation rate or mortality in post-extubated patients. Relevant studies regarding preventive use of various respiratory support methods, including COT, NIV, HFOT, and HFOT+NIV, after planned extubation in critically ill medical patients were searched systematically by two independent reviewers (Xu Z and Chen B) from database inception through December 19, 2019, in PubMed, Embase, Web of Science, and Cochrane Central Register of Controlled Trials. cache = ./cache/cord-027526-ohcu28rk.txt txt = ./txt/cord-027526-ohcu28rk.txt === reduce.pl bib === id = cord-005727-li8pwigg author = nan title = ESICM 2010 MONDAY SESSIONS 11 October 2010 date = 2010-08-31 pages = extension = .txt mime = text/plain words = 102770 sentences = 6408 flesch = 53 summary = Since, continuous epidural analgesia provides the required level of analgesia to support early mobilization and significant reduction in pulmonary and cardiovascular morbidity in the early postoperative period, we postulated that the use of low dose of continuous epidural morphine might improve postoperative analgesia and reduce undesirable side effects in elderly patientsTherefore, the present study was designed to evaluate the effects of morphine administered via epidural patients controlled analgesia and intravenous tramadol + metamizol on postoperative pain control and side effects in elderly patients after major abdominal surgery. For each ventilated patient the following data was registered:Age, APACHE II, the reason of admission, risk factors, use NIV, MV duration, timing of tracheostomy, time of diagnosis of VAP, microbiological data, length of stay and mortality in ICU. 23rd ESICM ANNUAL CONGRESS -BARCELONA, SPAIN -9-13 OCTOBER 2010 S131 Evaluated factors: patient characteristics, signs, symptoms, abscess location, time between symptoms and hospital admission and surgery, lab results, microbiology, antibiotic therapy, APACHE2, SAPS2, SOFA, length of ICU stay, surgical re-intervention, duration of mechanical ventilation, infectious complications, critical illness myopathy (CIM), renal replacement therapy (RRT), re-intubation, tracheotomy, mortality. cache = ./cache/cord-005727-li8pwigg.txt txt = ./txt/cord-005727-li8pwigg.txt === reduce.pl bib === id = cord-276238-2hv46ftk author = Ing, Richard J. title = The role of helmet-delivered noninvasive pressure support ventilation in COVID-19 patients date = 2020-05-08 pages = extension = .txt mime = text/plain words = 3072 sentences = 213 flesch = 49 summary = 5 The aim of this stand-alone editorial is to examine the role of helmet delivered continuous positive airway pressure (CPAP) noninvasive ventilation (NIV) as an adjunct to mechanical ventilation in patients requiring respiratory support in COVID-19. The recent Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 consensus statement agrees that; following admission for COVID-19, each patient may progress at a variable rate to either recovery, with minimal oxygen requirements and no ventilatory support, or a worsening of the disease process and the need for an escalation in NIV and mechanical ventilation. 11 The usual features of typical ARDS, recently termed the H-type, in COVID-19 patients are a progressive deteriorating lung compliance requiring increased inspired oxygen concentration(FiO 2 ), high positive end expiratory pressure (PEEP), prone ventilation, sedation with paralysis and inotropic support. cache = ./cache/cord-276238-2hv46ftk.txt txt = ./txt/cord-276238-2hv46ftk.txt === reduce.pl bib === id = cord-303292-iheq50ub author = De Jong, Audrey title = How to ventilate obese patients in the ICU date = 2020-10-23 pages = extension = .txt mime = text/plain words = 7496 sentences = 355 flesch = 41 summary = Regarding mechanical ventilation in patients with and without acute respiratory distress syndrome (ARDS), low tidal volume (6 ml/kg of predicted body weight) and moderate to high positive end-expiratory pressure (PEEP), with careful recruitment maneuver in selected patients, are advised. During invasive mechanical ventilation, patients with obesity are more prone to lung collapse and require higher PEEP to avoid it; low V T is calculated on predicted body weight. In a randomized controlled trial of the same team comparing HFNC to standard oxygen [87] in high-risk non-hypercapnic patients including 22% of patients with obesity, the study was stopped due to low recruitment after 155 patients, without any difference in extubation failure rate found between the two groups. PBW predicted body weight, PEEP positive end-expiratory pressure, ARDS acute respiratory distress syndrome, ECMO extracorporeal membrane oxygenation, CPAP continuous positive airway pressure, NIV noninvasive ventilation, HFNC high-flow nasal cannula oxygen patients. cache = ./cache/cord-303292-iheq50ub.txt txt = ./txt/cord-303292-iheq50ub.txt === reduce.pl bib === id = cord-293170-ir2y6sfz author = Lal, Tusharindra title = COVID-19 patients: when and whom to ventilate? date = 2020-08-19 pages = extension = .txt mime = text/plain words = 686 sentences = 37 flesch = 49 summary = As the cases of severe acute respiratory syndrome (SARS) increase rapidly, finding ICU beds, ventilators, intensivists, and critical care nurses remains a big challenge. A metaanalysis that included 1,084 patients from eight selected studies showed that high-flow nasal cannula (HFNC) treatment could reduce the rate of endotracheal intubation and ICU mortality [3] . A more recent review concluded that HFNC and NIV should be reserved for patients with mild acute respiratory distress syndrome until further data are available [4]. With medical facilities severely stretched out, especially in resource-limited regions like India and other developing nations with large population clusters, selective use of HFNC or NIV may reduce the need for ventilated ICU beds while achieving desired clinical results. Large RCTs or well-designed observational studies are needed to define stratification of COVID-19 patients for the best choice of initial respiratory support keeping in mind the resources available and the judicious and timely use of invasive ventilation. cache = ./cache/cord-293170-ir2y6sfz.txt txt = ./txt/cord-293170-ir2y6sfz.txt === reduce.pl bib === id = cord-313639-qpt47sx2 author = Zheng, Yi title = Clinical characteristics of 34 COVID-19 patients admitted to intensive care unit in Hangzhou, China date = 2020-05-20 pages = extension = .txt mime = text/plain words = 3723 sentences = 191 flesch = 49 summary = OBJECTIVE: This study summarizes and compares clinical and laboratory characteristics of 34 patients admitted to the intensive care unit (ICU) for complications from coronavirus disease 2019 (COVID-19) at the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China from Jan. 22 to Mar. 5, 2020. For this retrospective study, we analyzed data from patients admitted between Jan. 22 and Mar. 5, 2020, who had been diagnosed (according to the guidance of NHC (2020a)) with SARS-CoV-2 pneumonia in the ICU in the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. In this single-center case series of 34 ICU patients with SARS-CoV-2 infection in Hangzhou, China, 97.1% (33 cases) of patients had complications caused by ARDS, 44.1% (15) received IMV, 55.9% (19) only needed noninvasive respiratory support. cache = ./cache/cord-313639-qpt47sx2.txt txt = ./txt/cord-313639-qpt47sx2.txt === reduce.pl bib === id = cord-309518-seonrtn3 author = Alraddadi, Basem M. title = Noninvasive ventilation in critically ill patients with the Middle East respiratory syndrome date = 2019-03-18 pages = extension = .txt mime = text/plain words = 1996 sentences = 111 flesch = 45 summary = BACKGROUND: Noninvasive ventilation (NIV) has been used in patients with the Middle East respiratory syndrome (MERS) with acute hypoxemic respiratory failure, but the effectiveness of this approach has not been studied. [9] [10] [11] [12] While NIV may initially avoid the need for intubation and invasive mechanical ventilation (MV) , several studies have reported high failure rates and the need for invasive ventilation among patients with severe acute respiratory distress syndrome (ARDS) and an association with increased mortality. 12 In a recent analysis from the LUNG SAFE study on unselected patients with ARDS, NIV was associated with higher intensive care unit (ICU) mortality in patients with the ratio of partial pressure of oxygen to the fraction of inspired oxygen (PaO 2 /FiO 2 ) lower than 150 mm Hg. 12 The role of NIV in AHRF secondary to viral respiratory infections is unclear. cache = ./cache/cord-309518-seonrtn3.txt txt = ./txt/cord-309518-seonrtn3.txt === reduce.pl bib === id = cord-330704-4piesfxu author = Avdeev, Sergey N. title = Noninvasive ventilation for acute hypoxemic respiratory failure in patients with COVID-19 date = 2020-10-01 pages = extension = .txt mime = text/plain words = 1728 sentences = 107 flesch = 53 summary = MATERIALS & METHODS: In this retrospective cohort study, patients with confirmed diagnosis of COVID-19 and AHRF receiving NIV in general wards were recruited from two university-affiliated hospitals. However, there were major concerns that HFNC or NIV may create risks for health care workers (HCWs) because of SARS-CoV-2 transmission via aerosols [6] while the data on the efficacy of noninvasive modalities in COVID-19-associated AHRF are still limited [6] [7] [8] . This study suggests that the use of NIV is feasible in acute hypoxemic respiratory failure in patients with COVID-19 outside intensive care unit and can be considered as an effective means to improve oxygenation in patients not responding to conventional oxygen therapy. In summary, we have shown that NIV is feasible in patients with COVID-19 with acute hypoxemic respiratory failure outside the intensive care unit, and it can be considered as a valuable option for the management of AHRF in these patients. cache = ./cache/cord-330704-4piesfxu.txt txt = ./txt/cord-330704-4piesfxu.txt === reduce.pl bib === id = cord-336690-ajmuaw10 author = McEnery, Tom title = COVID-19: Respiratory support outside the intensive care unit date = 2020-04-09 pages = extension = .txt mime = text/plain words = 928 sentences = 53 flesch = 50 summary = The optimal mode of respiratory support for individuals with severe coronavirus disease 2019 (COVID-19) before invasive mechanical ventilation (IMV) is currently a subject of much debate. Recently published guidelines 1 and a Comment 2 differ substantially to other guidelines in this regard, with some advocating high flow nasal cannulae (HFNC) over non-invasive ventilation (NIV), 1,2 or vice versa (NHS guidance). In acute respiratory distress syndrome (ARDS), early intubation was associated with survival benefit when PaO 2 /FiO 2 ratio was <150 when compared with NIV. Conversely, data from only one study 6 on the severe acute respiratory syndrome (SARS) outbreak suggest that NIV can successfully avoid intubation. Non-invasive ventilation of patients with acute respiratory distress syndrome. Effectiveness of non-invasive positive pressure ventilation in the treatment of acute respiratory failure in severe acute respiratory syndrome Inspiratory work with and without continuous positive airway pressure in patients with acute respiratory failure cache = ./cache/cord-336690-ajmuaw10.txt txt = ./txt/cord-336690-ajmuaw10.txt === reduce.pl bib === id = cord-313816-7d8x7fjp author = Cinesi Gómez, C. title = Clinical Consensus Recommendations Regarding Non-Invasive Respiratory Support in the Adult Patient with Acute Respiratory Failure Secondary to SARS-CoV-2 infection date = 2020-05-07 pages = extension = .txt mime = text/plain words = 2984 sentences = 172 flesch = 54 summary = title: Clinical Consensus Recommendations Regarding Non-Invasive Respiratory Support in the Adult Patient with Acute Respiratory Failure Secondary to SARS-CoV-2 infection The document provides clinical recommendations for the noninvasive respiratory support (noninvasive ventilation, high flow oxygen therapy with nasal cannula) in any patient with suspected or confirmed presentation of COVID-19 with acute respiratory failure. It includes a more detailed description of the recommendations for the use of non-invasive respiratory support (NIRS) in the management of acute respiratory failure (ARF) secondary to infection by the new SARS-CoV-2 coronavirus that causes the disease called COVID-19 that is intended to supplement the regularly updated recommendations issued by the Ministry of Health, Consumer Affairs and Social Welfare (MH) 1,2 . cache = ./cache/cord-313816-7d8x7fjp.txt txt = ./txt/cord-313816-7d8x7fjp.txt === reduce.pl bib === id = cord-027805-p0bhju1s author = Wong, An-Kwok Ian title = Consequences and Solutions for the Impact of Communication Impairment on Noninvasive Ventilation Therapy for Acute Respiratory Failure: A Focused Review date = 2020-06-15 pages = extension = .txt mime = text/plain words = 4344 sentences = 239 flesch = 40 summary = DATA SOURCES: We searched MEDLINE and Google Scholar for "speech," "communication," "impairment," "failure," "complications," "NIPPV," "NIV," and "noninvasive ventilation." STUDY SELECTION: We included articles with patients in acute respiratory failure. Analogous communication problems exist with effective solutions in other fields, such as fighter pilot masks, that can be easily implemented to enhance noninvasive ventilation patient care, increase adherence to noninvasive ventilation treatment, and improve patient outcomes. W ith landmark trials demonstrating the efficacy of noninvasive ventilation (NIV) in cardiogenic pulmonary edema and acute exacerbations of chronic obstructive pulmonary disease, NIV has changed the standard of care for acute respiratory failure (ARF) and reduced the amount of invasive mechanical ventilation (IMV) being used (1) (2) (3) (4) . Noninvasive mechanical ventilation via face mask in patients with acute respiratory failure who refused endotracheal intubation cache = ./cache/cord-027805-p0bhju1s.txt txt = ./txt/cord-027805-p0bhju1s.txt === reduce.pl bib === id = cord-352059-1bjskqyg author = Gupta, Nivedita title = Laboratory preparedness for SARS-CoV-2 testing in India: Harnessing a network of Virus Research & Diagnostic Laboratories date = 2020-04-28 pages = extension = .txt mime = text/plain words = 4174 sentences = 224 flesch = 53 summary = The Indian Council of Medical Research (ICMR)-National Institute of Virology (NIV), Pune, which is the apex laboratory for viral diagnosis and research in India, optimized the conventional and real-time PCR assays targeting different genomic regions of SARS-CoV-2 and initiated testing of suspected cases. Before initiating testing of clinical specimens from suspected cases of SARS-CoV-2, each VRDL shared results from the rRT-PCR runs performed with positive and negative controls with the apex laboratory (NIV, Pune). Expansion of testing capabilities and selection of testing laboratories for SARS-CoV-2: Following the increase in the load of screening samples from suspected cases with symptoms and travel history to China or asymptomatic persons with travel history to Wuhan after January 15, 2020, it was decided that strategically located VRDLs needed to start testing for SARS-CoV-2 in addition to Thereafter, NCDC, Delhi, initiated independent testing; however, results were shared with ICMR on a daily basis. cache = ./cache/cord-352059-1bjskqyg.txt txt = ./txt/cord-352059-1bjskqyg.txt === reduce.pl bib === id = cord-290684-3f6prlqy author = Duan, Jun title = Use of high-flow nasal cannula and noninvasive ventilation in patients with COVID-19: A multicenter observational study date = 2020-07-29 pages = extension = .txt mime = text/plain words = 2818 sentences = 185 flesch = 62 summary = title: Use of high-flow nasal cannula and noninvasive ventilation in patients with COVID-19: A multicenter observational study BACKGROUND: The use of high-flow nasal cannula (HFNC) and noninvasive ventilation (NIV) in patients with COVID-19 is debated. CONCLUSIONS: In critically ill patients with COVID-19 who used HFNC and NIV as first-line therapy, the duration of HFNC + NIV, intubation rate and mortality did not differ between two groups. The Asian Critical Care Clinical Trials Group has suggested that the HFNC and NIV only can be used in COVID-19 patients with mild acute respiratory distress syndrome (ARDS) [21] . cache = ./cache/cord-290684-3f6prlqy.txt txt = ./txt/cord-290684-3f6prlqy.txt === reduce.pl bib === id = cord-352850-as12ll8s author = Wang, Tao title = Clinical Features of Coronavirus Disease 2019 Patients With Mechanical Ventilation: A Nationwide Study in China date = 2020-06-23 pages = extension = .txt mime = text/plain words = 2022 sentences = 109 flesch = 48 summary = title: Clinical Features of Coronavirus Disease 2019 Patients With Mechanical Ventilation: A Nationwide Study in China Mechanical ventilation is lifesaving for respiratory distress, this study was designed to delineate the clinical features of the coronavirus disease 2019 patients with mechanical ventilation from a national cohort in China. Multivariate regression analysis showed that higher odds of in-hospital death was associated with invasive mechanical ventilation requirement (hazard ratio: 2.95; 95% CI, 1.40–6.23; p = 0.005), and coexisting chronic obstructive pulmonary disease (hazard ratio, 4.57; 95% CI, 1.65–12.69; p = 0.004) and chronic renal disease (hazard ratio, 5.45; 95% CI, 1.85–16.12; p = 0.002). Compared with NIV group, IMV cases had higher levels of lactate dehydrogenase, d-dimer, CRP and WBC count, and lower levels of albumin and oxygenation index (Table E2 , Supplemental Digital Content 1, http://links.lww.com/CCM/ F609); and showed a higher incidence of elevated d-dimer at admission with multivariate logistic regression analysis (>1.5 mg/L; HR, 3.05; 95% CI, 1.07-8.69, p = 0.037) ( Table 1) . cache = ./cache/cord-352850-as12ll8s.txt txt = ./txt/cord-352850-as12ll8s.txt === reduce.pl bib === id = cord-335078-z7k59k8o author = Burton-Papp, Helmi C. title = Conscious prone positioning during non-invasive ventilation in COVID-19 patients: experience from a single centre date = 2020-07-31 pages = extension = .txt mime = text/plain words = 3765 sentences = 182 flesch = 43 summary = In our cohort of 20 COVID-19 patients with moderate acute hypoxic respiratory failure, prone positioning with non-invasive ventilation resulted in improved oxygenation. Here we build on this literature offering an examination of changes in oxygenation, as measured by PaO 2 /FiO 2 , across multiple episodes of prone positioning in conscious patients, with moderate to severe hypoxia, undergoing non-invasive ventilation following admission to the intensive care unit for advanced respiratory support. Although there is only limited data available on the effectiveness of non-invasive ventilation (NIV) in COVID-19, early provision of NIV in moderate to severe acute hypoxic respiratory failure is associated with reduced ICU mortality and intubation rate 12 . This is a retrospective report on a subgroup of 20 patients with severe COVID-19 who were able to self-prone while receiving non-invasive ventilation in the ICU, among a grand total of 81 patients admitted to the ICU during the study period.The primary outcome reported by the authors is change in PaO2/FiO2 ratio while in prone position. cache = ./cache/cord-335078-z7k59k8o.txt txt = ./txt/cord-335078-z7k59k8o.txt === reduce.pl bib === id = cord-327622-ezgufe24 author = Kaur, Ramandeep title = Practical strategies to reduce nosocomial transmission to healthcare professionals providing respiratory care to patients with COVID-19 date = 2020-09-23 pages = extension = .txt mime = text/plain words = 6333 sentences = 355 flesch = 43 summary = • When removing the endotracheal tube, simultaneously turn off the ventilator • Avoid disconnecting ETT from the ventilator circuit before extubation to reduce spray of contaminated aerosols 9 Transport • Place a filter between the artificial airway and the transport ventilator circuit • Use HME that has filter function (HME-F) • Consider clamping the ETT before disconnection from ventilator circuit 10 Bronchoscopy assist* 2 in vivo [44, 45] • For spontaneously breathing patients, place a surgical mask on patient's face (Fig. 7a, b) • Use NIV mask with examination port for patients on NIV (Fig. 7d) • Use swivel adapter to insert bronchoscope for intubated patient (Fig. 7c) Abbreviations: HFNC high-flow nasal cannula, IPPB intermittent positive pressure breathing, HME heat moisture exchanger, ETT endotracheal tube, NIV non-invasive ventilation *Based on CDC guidelines, these procedures should ideally be performed in airborne infection isolation rooms entrainment or nonrebreather mask [53] . cache = ./cache/cord-327622-ezgufe24.txt txt = ./txt/cord-327622-ezgufe24.txt === reduce.pl bib === id = cord-344641-rog2h4g7 author = Franco, Cosimo title = Feasibility and clinical impact of out-of-ICU non-invasive respiratory support in patients with COVID-19 related pneumonia date = 2020-08-03 pages = extension = .txt mime = text/plain words = 3700 sentences = 163 flesch = 49 summary = INTRODUCTION: The Coronavirus 2(SARS-CoV-2) outbreak spread rapidly in Italy and the lack of intensive care unit(ICU) beds soon became evident, forcing the application of noninvasive respiratory support(NRS) outside the ICU, raising concerns over staff contamination. Data were collected including medication, mode and usage of the NRS (i.e. high-flow nasal cannula (HFNC), continuous positive airway pressure (CPAP), noninvasive ventilation(NIV)), length of stay in hospital, endotracheal intubation(ETI) and deaths. Variables recorded for each patient were obtained for the period from March 1 st until May 10 th 2020 and included the following: demographics (age, sex), comorbidities (type and number), respiratory condition at admission (respiratory rate (RR), PaO 2 /FiO 2 ratio), medications (type of drugs prescribed), mode and usage of the NRS (ventilatory settings for NIV and CPAP, and flow rate for HFNC), and stay in hospital (days). cache = ./cache/cord-344641-rog2h4g7.txt txt = ./txt/cord-344641-rog2h4g7.txt === reduce.pl bib === id = cord-354330-pud2rqxk author = Pirzada, Abdul Rouf title = Management of Aerosol during Noninvasive Ventilation for Patients with Sleep-Disordered Breathing: Important Messages during the COVID-19 Pandemic date = 2020-06-17 pages = extension = .txt mime = text/plain words = 3206 sentences = 148 flesch = 46 summary = The procedures that are believed to have a potential to generate aerosols and droplets as a source of respiratory pathogens include positive pressure ventilation (bilevel positive airway pressure (BPAP) and continuous positive airway pressure (CPAP)), endotracheal intubation, airway suction, high-frequency oscillatory ventilation, tracheostomy, chest physiotherapy, nebulizer treatment, sputum induction, and bronchoscopy [5] [6] [7] . In the hospital, the procedures that are believed to or have a potential to generate aerosols and droplets as a source of respiratory pathogens include positive pressure ventilation (BiPAP and CPAP), endotracheal intubation, airway suction, high-frequency oscillatory ventilation, tracheostomy, chest physiotherapy, nebulizer treatment, sputum induction, and bronchoscopy [5, 8] . NIV in hospital, in a setting of suspected or confirmed case of COVID-19, warrants infectious disease protocol of isolation in negative pressure room preferably with an anteroom and attached washroom (well ventilated) and personal protective equipment for attending staff; however, it is not possible in high volume patient inflow. cache = ./cache/cord-354330-pud2rqxk.txt txt = ./txt/cord-354330-pud2rqxk.txt === reduce.pl bib === id = cord-355450-v3eh1rtk author = Boattini, Matteo title = Influenza and respiratory syncytial virus infections in the oldest-old continent date = 2020-06-27 pages = extension = .txt mime = text/plain words = 2668 sentences = 125 flesch = 42 summary = Influenza and respiratory syncytial virus (RSV) infections are associated with high rate of morbidity, mortality, and an important burden on healthcare systems worldwide, especially among elderly patients [1] [2] [3] [4] [5] [6] . Especially in epidemiological research, oldest-old patients are considered to be a part of the wider age group of the elderly (≥ 65 years old), and there is limited published evidence about predictors of severity of illness and mortality in viral infections, such as caused by influenza and RSV. The aim of this study was to describe the clinical features of an oldest-old population admitted with influenza and/or RSV infections in three southern European hospitals over two consecutive winter seasons and identify predictors of pneumonia, non-invasive ventilation (NIV), and in-hospital death (IHD). Moreover, in our study, hospital-acquired influenza and/or RSV infections were not identified as predictors of pneumonia, use of NIV, and IHD for patients aged 65 years and older, moving away from evidence available so far [9, 10] . cache = ./cache/cord-355450-v3eh1rtk.txt txt = ./txt/cord-355450-v3eh1rtk.txt === reduce.pl bib === id = cord-312864-km07zhn1 author = Potalivo, A. title = Sixty-day mortality among 520 Italian hospitalized COVID-19 patients according to the adopted ventilatory strategy in the context of an integrated multidisciplinary clinical organization: a population-based cohort study date = 2020-08-15 pages = extension = .txt mime = text/plain words = 5381 sentences = 255 flesch = 50 summary = title: Sixty-day mortality among 520 Italian hospitalized COVID-19 patients according to the adopted ventilatory strategy in the context of an integrated multidisciplinary clinical organization: a population-based cohort study 4, 8, 9, 11 Thus, the number of hospitalized COVID-19 patients treated with oxygen supplementation and NIV has been markedly underreported leading to inaccurate information regarding the overall use of the different respiratory supports and outcomes. Using clinical and demographics information routinely collected in a unique database including all residents in the entire province, we performed the present population-based cohort study with the following aims: 1) to describe the characteristics of hospitalized COVID-19 patients, 2) to examine patient outcomes overall and stratified by the adopted respiratory support, 3) to describe the organization of local healthcare system. It should be noted that in our study we documented for patients treated with NIV and/or IMV -despite a similar P/F ratio (median 98.0; IQR 84.0-124.5) and a higher SOFA score (median 8; IQR 6-10)-a considerably lower 60-day mortality rate, overall and in individual groups. cache = ./cache/cord-312864-km07zhn1.txt txt = ./txt/cord-312864-km07zhn1.txt === reduce.pl bib === id = cord-335975-m6lkrehi author = nan title = Proceedings of Réanimation 2018, the French Intensive Care Society International Congress date = 2018-02-05 pages = extension = .txt mime = text/plain words = 89374 sentences = 5327 flesch = 52 summary = A qSOFA score relying on 3 simple clinical criteria (respiratory rate, mental status and systolic blood pressure) has been proposed to better identify septic patients with associated higher mortality outside the intensive care unit (Seymour CW et al., JAMA 2016) . We propose to determine whether the arterial oxygen pressure (PaO2) at intensive care unit (ICU) admission affects mortality at day 28 (D28) in patients with septic shock subjected to mechanical out-of-hospital ventilation. Conclusion: In this study, we report a significant association between hyperoxemia at ICU admission and mortality at D28 in patients with septic shock subjected to pre-hospital invasive mechanical ventilation. The aim of this study was to describe outcome of pediatric patient with hematologic disease hospitalized in our intensive care unit for respiratory failure and to investigate the clinical variables associated with mortality. cache = ./cache/cord-335975-m6lkrehi.txt txt = ./txt/cord-335975-m6lkrehi.txt === reduce.pl bib === id = cord-352577-h3652seb author = Kopić, Jasminka title = Expanding the Use of Noninvasive Ventilation During an Epidemic date = 2014-08-27 pages = extension = .txt mime = text/plain words = 3340 sentences = 183 flesch = 39 summary = 4 When appropriately indicated and promptly administered, NIV offers an alternative to tracheal intubation, sedation, risk of infection, and myriad complications associated with invasive ventilation, and it can promote rapid respiratory recovery, and reduce a patient's dependence on critical care facilities. Rello et al described NIV use at ICU admission in 1 of 3 patients with H1N1 virus and respiratory failure, but 75% of them had an unfavorable clinical course and required tracheal intubation and invasive mechanical ventilation. In a position statement, the Australian Society for Infectious Diseases recommends "reserving negative-pressure ventilation rooms (if available) for intensive care patients, especially those receiving non-invasive ventilation." 31 The UK Department of Health, in "Guidance for infection control in critical care for pandemic influenza," approved the use of NIV under strict infection control measures. cache = ./cache/cord-352577-h3652seb.txt txt = ./txt/cord-352577-h3652seb.txt === reduce.pl bib === id = cord-010669-rg2p3kal author = Fubini, PE title = Prehospital reversal of profound respiratory acidosis and hypercapnic coma by non-invasive ventilation: a report of two cases date = 2020-05-07 pages = extension = .txt mime = text/plain words = 2005 sentences = 97 flesch = 45 summary = BACKGROUND: In chronic obstructive pulmonary disease (COPD) patients with acute respiratory failure (ARF), non-invasive ventilation (NIV) is generally recommended and has proven its benefits by reducing endotracheal intubation (ETI) rates, intensive care unit (ICU) admissions, complications, and mortality. CASE PRESENTATION: We report two cases of ARF in COPD patients who were successfully treated by NIV in prehospital setting and avoided ETI despite contraindications (altered mental status with a Glasgow Coma Scale < 8) and failure risk factors (severe respiratory acidosis with pH < 7.25). Acute respiratory failure (ARF) in chronic obstructive pulmonary disease (COPD) patients is a well-known indication for non-invasive ventilation (NIV) trial [1] . We report here two cases of ARF in COPD patients with severe respiratory acidosis and hypercapnic coma successfully treated by NIV in the prehospital setting. In conclusion, for COPD patients presenting ARF, NIV trial could be considered even when relative contraindications such as an altered level of consciousness or a severe respiratory acidosis are present. cache = ./cache/cord-010669-rg2p3kal.txt txt = ./txt/cord-010669-rg2p3kal.txt === reduce.pl bib === id = cord-268049-7xqln70d author = Montrief, Tim title = COVID-19 respiratory support in the emergency department setting date = 2020-08-08 pages = extension = .txt mime = text/plain words = 5197 sentences = 337 flesch = 45 summary = DISCUSSION: Patients presenting with SARS-CoV-2 infection are at high risk for acute respiratory failure requiring airway management. [29] [30] [31] [32] Based on currently available evidence, the WHO states that "HFNC and NIV systems with good interface fitting do not create widespread dispersion of exhaled air and therefore should be associated with [a] low risk of airborne transmission." 15 The risk of respiratory pathogen transmission when using HFNC is subject to a variety of factors, including the duration of support, maximal flow rate, patient sneezing or coughing, cannula fit, and patient cooperation. 35 Many guidelines, including those by Australian and New Zealand Intensive Care Society (ANZICS), the WHO, and the Surviving Sepsis Campaign recommend the use of HFNC in COVID-19 patients presenting with acute hypoxemic respiratory failure unresponsive to conventional oxygen therapy. 20 Notably, the SCCM guidelines on the management of critically ill patients with COVID-19 recommend "a trial of NIV with close monitoring and shortinterval assessment for worsening of respiratory failure" if HFNC is not available and there is no urgent indication for intubation. cache = ./cache/cord-268049-7xqln70d.txt txt = ./txt/cord-268049-7xqln70d.txt === reduce.pl bib === id = cord-355038-o2hr5mox author = nan title = Proceedings of Réanimation 2020, the French Intensive Care Society International Congress date = 2020-02-11 pages = extension = .txt mime = text/plain words = 102485 sentences = 7028 flesch = 52 summary = Conclusion: In patients with moderate-to-severe ARDS, a higher tidal volume under PSV within the 72 h following neuromuscular blockers cessation is independently associated with the 28-day mortality.Compliance with ethics regulations: Yes. Kaplan-Meier estimate of the cumulative probability of survival according to the mean tidal volume (Vt)-lower of higher than 8 ml/ kg-under pressure support ventilation (PSV) during the "transition period" transfusion is associated with adverse events, and equipoise remains on the optimal transfusion strategy in oncologic patients in surgical setting. Compliance with ethics regulations: Yes. Patients and methods: In a retrospective monocentric study (01/2013-01/2017) conducted in cardio-vascular surgical intensive care unit (ICU) in Henri Mondor teaching hospital, all consecutive adult patients who underwent peripheral VA-ECMO were included, with exclusion of those dying in the first 24 h. Compliance with ethics regulations: Yes. Rationale: Acute respiratory failure is the leading reason for intensive care unit (ICU) admission in immunocompromised patients and the need for invasive mechanical ventilation has become a major clinical end-point in randomized controlled trials (RCT). cache = ./cache/cord-355038-o2hr5mox.txt txt = ./txt/cord-355038-o2hr5mox.txt === reduce.pl bib === id = cord-013149-y0dbhtef author = Wohlfarth, P. title = Hämatoonkologie und Intensivmedizin: Vom Tabu zur Conditio sine qua non date = 2020-10-12 pages = extension = .txt mime = text/plain words = 2333 sentences = 260 flesch = 35 summary = Timing der Intensivstationsaufnahme Die vorhandenen Daten über kritisch kranke Krebspatienten mit den häufigsten Intensivstationsaufnahmegründen, ARV und Sepsis, zeigen einmütig, dass eine möglichst frühzeitige Verlegung auf die Intensivstation, also bei manifestem oder eventuell auch nur drohendem Organversagen, erfolgen sollte [8, 9] . Bei Patienten mit "chronic obstructive pulmonary disease" (COPD) und hypertensivem Lungenödem stellt die nichtinvasive Beatmung (NIV) den Goldstandard der Therapie dar und es gibt keine evidenzbasierte Rationale, dass dies nicht auch bei Krebspatienten gelten sollte. These include defining proper goals of intensive care treatment, managing acute respiratory failure with diverse differential considerations, treating immunologic side-effects of ever new and innovative cancer therapies, as well as numerous clinical scenarios which may exclusively arise in cancer patients. Cancer · Intensive care unit · Acute respiratory failure · Immunotherapy · iCHOP und womöglich "um jeden Preis" nicht zu intubieren, kann somit als überholt, ja im Fall sekundärerIntubationenbeiNIV-Versagen sogar als potenziell gefährlich angesehen werden. cache = ./cache/cord-013149-y0dbhtef.txt txt = ./txt/cord-013149-y0dbhtef.txt === reduce.pl bib === id = cord-346565-vsgbmxzv author = Cascella, Marco title = Rapid and Impressive Response to a Combined Treatment with Single-Dose Tocilizumab and NIV in a Patient with COVID-19 Pneumonia/ARDS date = 2020-07-27 pages = extension = .txt mime = text/plain words = 3855 sentences = 200 flesch = 48 summary = Treatment of acute respiratory distress syndrome (ARDS) due to COVID-19 pneumonia (CARDS) represents a clinical challenge, requiring often invasive mechanical ventilation (IMV). Despite that at the beginning of the pandemic, early invasive mechanical ventilation was indicated as the optimal strategy for CARDS management, in COVID-19 pneumonia the clinical picture of severe hypoxemia contrasted with the typical ARDS respiratory mechanics. Clinical experience, for example, suggested that non-invasive ventilation (NIV) has a role of primary importance in the management of CARDS as it can improve oxygenation, limiting the work of the respiratory muscles and preventing the onset of the patient self-inflicted lung injury (P-SILI) [2] . In this setting, adding the prone position to NIV could improve oxygenation, decrease respiratory effort, reducing self-induced lung injury, and avoid the need of intubation and invasive ventilation, which could be particularly useful in the case of reduced availability of intensive care unit (ICU) beds [4] [5] [6] . cache = ./cache/cord-346565-vsgbmxzv.txt txt = ./txt/cord-346565-vsgbmxzv.txt === reduce.pl bib === id = cord-016897-t71f10kv author = Flores, Marco V. title = Preventing Airborne Disease Transmission: Implications for Patients During Mechanical Ventilation date = 2013-05-29 pages = extension = .txt mime = text/plain words = 3661 sentences = 196 flesch = 46 summary = We discuss the risk of transmitting these procedures and the strategies for mechanical ventilation in future airborne epidemics with special consideration given to the issue of protecting health care workers (HCWs). In contrast to the situation regarding severe acute respiratory syndrome (SARS) or tuberculosis prevention in HCWs, little attention has been given to the importance of HCWs personal protective equipment (PPE) (gowns, gloves, masks) for prevention and management of infl uenza. There is also potential for NIV to reduce the need for intubation in patients with infl uenza pneumonia or chronic respiratory disease, facilitate extubation, and widen the provision of ventilator support outside the intensive care unit (ICU). Evaluation of droplet dispersion during non-invasive ventilation, oxygen therapy, nebulizer treatment and chest physiotherapy in clinical practice: implications for management of pandemic infl uenza and other airbone infections Aerosol generating procedures and risk of transmission of acute respiratory infections to healthcare workers: a systematic review cache = ./cache/cord-016897-t71f10kv.txt txt = ./txt/cord-016897-t71f10kv.txt ===== Reducing email addresses cord-027805-p0bhju1s cord-014538-6a2pviol cord-352850-as12ll8s cord-335975-m6lkrehi cord-355038-o2hr5mox Creating transaction Updating adr table ===== Reducing keywords cord-029392-5s5686i9 cord-016042-iyuca9lv cord-030131-klhg7x8z cord-002078-38rmx65j cord-000619-3bakci02 cord-016416-h3cjylcl cord-009375-2hflah2h cord-000705-w52dc97h cord-011269-j2rogzm7 cord-017240-2vqehqfh cord-014538-6a2pviol cord-016844-lq2bgu7a cord-016744-jzhuq4te cord-017282-rahtmu3h cord-011222-7aha5b07 cord-010850-zj6k7wz9 cord-034578-i9rdubix cord-017786-kfl6xt31 cord-267537-akzydy7l cord-103020-ckuma42j cord-015548-zjrkfe9b cord-034185-e0am7pa6 cord-260220-f1tpkw1o cord-303292-iheq50ub cord-313639-qpt47sx2 cord-005727-li8pwigg cord-027526-ohcu28rk cord-276238-2hv46ftk cord-293170-ir2y6sfz cord-309518-seonrtn3 cord-330704-4piesfxu cord-027805-p0bhju1s cord-336690-ajmuaw10 cord-313816-7d8x7fjp cord-352059-1bjskqyg cord-352850-as12ll8s cord-327622-ezgufe24 cord-290684-3f6prlqy cord-335078-z7k59k8o cord-312864-km07zhn1 cord-355450-v3eh1rtk cord-335975-m6lkrehi cord-344641-rog2h4g7 cord-354330-pud2rqxk cord-010669-rg2p3kal cord-268049-7xqln70d cord-352577-h3652seb cord-355038-o2hr5mox cord-013149-y0dbhtef cord-016897-t71f10kv cord-346565-vsgbmxzv Creating transaction Updating wrd table ===== Reducing urls cord-030131-klhg7x8z cord-029392-5s5686i9 cord-103020-ckuma42j cord-267537-akzydy7l cord-352850-as12ll8s cord-027526-ohcu28rk cord-312864-km07zhn1 cord-013149-y0dbhtef Creating transaction Updating url table ===== Reducing named entities cord-002078-38rmx65j cord-030131-klhg7x8z cord-000619-3bakci02 cord-016042-iyuca9lv cord-016416-h3cjylcl cord-000705-w52dc97h cord-017240-2vqehqfh cord-009375-2hflah2h cord-016744-jzhuq4te cord-011269-j2rogzm7 cord-014538-6a2pviol cord-017282-rahtmu3h cord-016844-lq2bgu7a cord-034578-i9rdubix cord-011222-7aha5b07 cord-015548-zjrkfe9b cord-010850-zj6k7wz9 cord-017786-kfl6xt31 cord-260220-f1tpkw1o cord-027526-ohcu28rk cord-267537-akzydy7l cord-103020-ckuma42j cord-034185-e0am7pa6 cord-276238-2hv46ftk cord-303292-iheq50ub cord-309518-seonrtn3 cord-330704-4piesfxu cord-293170-ir2y6sfz cord-005727-li8pwigg cord-313639-qpt47sx2 cord-313816-7d8x7fjp cord-336690-ajmuaw10 cord-352059-1bjskqyg cord-027805-p0bhju1s cord-290684-3f6prlqy cord-352850-as12ll8s cord-335078-z7k59k8o cord-327622-ezgufe24 cord-354330-pud2rqxk cord-344641-rog2h4g7 cord-312864-km07zhn1 cord-335975-m6lkrehi cord-268049-7xqln70d cord-016897-t71f10kv cord-355450-v3eh1rtk cord-029392-5s5686i9 cord-013149-y0dbhtef cord-346565-vsgbmxzv cord-010669-rg2p3kal cord-352577-h3652seb cord-355038-o2hr5mox Creating transaction Updating ent table ===== Reducing parts of speech cord-029392-5s5686i9 cord-016042-iyuca9lv cord-002078-38rmx65j cord-030131-klhg7x8z cord-016416-h3cjylcl cord-000619-3bakci02 cord-009375-2hflah2h cord-000705-w52dc97h cord-017240-2vqehqfh cord-016744-jzhuq4te cord-017282-rahtmu3h cord-011269-j2rogzm7 cord-011222-7aha5b07 cord-034578-i9rdubix cord-016844-lq2bgu7a cord-015548-zjrkfe9b cord-010850-zj6k7wz9 cord-017786-kfl6xt31 cord-103020-ckuma42j cord-293170-ir2y6sfz cord-276238-2hv46ftk cord-260220-f1tpkw1o cord-027526-ohcu28rk cord-267537-akzydy7l cord-313639-qpt47sx2 cord-309518-seonrtn3 cord-303292-iheq50ub cord-313816-7d8x7fjp cord-330704-4piesfxu cord-336690-ajmuaw10 cord-352059-1bjskqyg cord-034185-e0am7pa6 cord-335078-z7k59k8o cord-327622-ezgufe24 cord-027805-p0bhju1s cord-290684-3f6prlqy cord-352850-as12ll8s cord-344641-rog2h4g7 cord-354330-pud2rqxk cord-312864-km07zhn1 cord-268049-7xqln70d cord-346565-vsgbmxzv cord-352577-h3652seb cord-016897-t71f10kv cord-355450-v3eh1rtk cord-014538-6a2pviol cord-010669-rg2p3kal cord-013149-y0dbhtef cord-005727-li8pwigg cord-335975-m6lkrehi cord-355038-o2hr5mox Creating transaction Updating pos table Building ./etc/reader.txt cord-005727-li8pwigg cord-014538-6a2pviol cord-335975-m6lkrehi cord-005727-li8pwigg cord-355038-o2hr5mox cord-014538-6a2pviol number of items: 51 sum of words: 546,666 average size in words: 10,718 average readability score: 46 nouns: patients; study; ventilation; mortality; care; failure; results; group; risk; data; pressure; hospital; use; analysis; rate; days; cases; admission; patient; treatment; intubation; time; therapy; infection; years; oxygen; methods; age; factors; outcome; studies; support; lung; blood; period; score; disease; conclusion; unit; surgery; groups; management; day; stay; pneumonia; level; outcomes; shock; flow; control verbs: used; including; associated; compare; increased; shown; performed; admitted; require; assess; received; following; reduced; found; identified; treated; reported; improves; evaluate; based; considered; suggested; according; related; undergoing; defined; measuring; developed; described; collected; remains; determine; provided; needed; induced; occurs; observed; decreases; conducted; controlled; recommended; studied; predicting; present; analyzed; ventilated; lead; recorded; allowed; obtained adjectives: respiratory; acute; clinical; high; severe; intensive; non; mechanical; invasive; higher; significant; first; positive; medical; ill; pulmonary; mean; cardiac; noninvasive; median; early; retrospective; prospective; different; septic; lower; low; patient; postoperative; post; therapeutic; arterial; chronic; critical; renal; common; available; surgical; major; main; randomized; similar; standard; continuous; thoracic; observational; frequent; initial; specific; fluid adverbs: also; significantly; however; critically; respectively; well; especially; therefore; often; still; even; frequently; mainly; mechanically; independently; previously; particularly; recently; statistically; finally; less; first; potentially; least; furthermore; prospectively; retrospectively; prior; moreover; currently; nevertheless; commonly; rather; highly; alone; usually; directly; mostly; probably; overall; already; approximately; subsequently; strongly; clinically; severely; rapidly; poorly; n't; better pronouns: we; our; it; their; its; they; them; i; his; us; he; you; themselves; itself; her; she; one; himself; him; your; my; trs\3; s; rrt; puc; pk/; ours; oneself; olhf).the; mrs; herself; em proper nouns: ICU; NIV; ARDS; CI; HFNC; ±; COPD; VAP; F; Care; IMV; COVID-19; SARS; Fig; II; CPAP; January; AKI; Intensive; OBJECTIVES; H1N1; MV; ECMO; mg; L; Hospital; METHODS; France; China; CoV-2; kg; C; IQR; Table; December; hypercapnic; ARF; NiV; APACHE; •; PP; University; SAPS; PCT; CT; Society; PICU; INTRODUCTION; Jean; Health keywords: niv; patient; icu; sars; covid-19; imv; hfnc; day; ards; vap; study; january; h1n1; group; cpap; copd; care; sofa; result; mortality; hospital; ecmo; aki; ventilation; peep; method; iqr; introduction; intensive; high; france; december; ahrf; acute; university; unit; thoracic; surgery; strength; saps; rsv; rationale; pune; postoperative; pierre; picu; pct; patienten; objectives; nrs one topic; one dimension: patients file(s): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366473/ titles(s): Effect of oxygenation modalities among patients with postoperative respiratory failure: a pairwise and network meta-analysis of randomized controlled trials three topics; one dimension: patients; patients; patients file(s): https://www.ncbi.nlm.nih.gov/pubmed/32048060/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582032/, https://www.ncbi.nlm.nih.gov/pubmed/32242875/ titles(s): Proceedings of Réanimation 2020, the French Intensive Care Society International Congress | Recommendations from the Italian intersociety consensus on Perioperative Anesthesa Care in Thoracic surgery (PACTS) part 2: intraoperative and postoperative care | Laboratory preparedness for SARS-CoV-2 testing in India: Harnessing a network of Virus Research & Diagnostic Laboratories five topics; three dimensions: patients icu study; patients niv respiratory; niv will copd; obesity influenza patients; testing cov sars file(s): https://www.ncbi.nlm.nih.gov/pubmed/32048060/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582032/, https://www.ncbi.nlm.nih.gov/pubmed/31570878/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121120/, https://www.ncbi.nlm.nih.gov/pubmed/32242875/ titles(s): Proceedings of Réanimation 2020, the French Intensive Care Society International Congress | Recommendations from the Italian intersociety consensus on Perioperative Anesthesa Care in Thoracic surgery (PACTS) part 2: intraoperative and postoperative care | An antibody against the F glycoprotein inhibits Nipah and Hendra virus infections | Noninvasive Mechanical Ventilation: Models to Assess Air and Particle Dispersion | Laboratory preparedness for SARS-CoV-2 testing in India: Harnessing a network of Virus Research & Diagnostic Laboratories Type: cord title: keyword-niv-cord date: 2021-05-25 time: 15:41 username: emorgan patron: Eric Morgan email: emorgan@nd.edu input: keywords:niv ==== make-pages.sh htm files ==== make-pages.sh complex files ==== make-pages.sh named enities ==== making bibliographics id: cord-309518-seonrtn3 author: Alraddadi, Basem M. title: Noninvasive ventilation in critically ill patients with the Middle East respiratory syndrome date: 2019-03-18 words: 1996 sentences: 111 pages: flesch: 45 cache: ./cache/cord-309518-seonrtn3.txt txt: ./txt/cord-309518-seonrtn3.txt summary: BACKGROUND: Noninvasive ventilation (NIV) has been used in patients with the Middle East respiratory syndrome (MERS) with acute hypoxemic respiratory failure, but the effectiveness of this approach has not been studied. [9] [10] [11] [12] While NIV may initially avoid the need for intubation and invasive mechanical ventilation (MV) , several studies have reported high failure rates and the need for invasive ventilation among patients with severe acute respiratory distress syndrome (ARDS) and an association with increased mortality. 12 In a recent analysis from the LUNG SAFE study on unselected patients with ARDS, NIV was associated with higher intensive care unit (ICU) mortality in patients with the ratio of partial pressure of oxygen to the fraction of inspired oxygen (PaO 2 /FiO 2 ) lower than 150 mm Hg. 12 The role of NIV in AHRF secondary to viral respiratory infections is unclear. abstract: BACKGROUND: Noninvasive ventilation (NIV) has been used in patients with the Middle East respiratory syndrome (MERS) with acute hypoxemic respiratory failure, but the effectiveness of this approach has not been studied. METHODS: Patients with MERS from 14 Saudi Arabian centers were included in this analysis. Patients who were initially managed with NIV were compared to patients who were managed only with invasive mechanical ventilation (invasive MV). RESULTS: Of 302 MERS critically ill patients, NIV was used initially in 105 (35%) patients, whereas 197 (65%) patients were only managed with invasive MV. Patients who were managed with NIV initially had lower baseline SOFA score and less extensive infiltrates on chest radiograph compared with patients managed with invasive MV. The vast majority (92.4%) of patients who were managed initially with NIV required intubation and invasive mechanical ventilation, and were more likely to require inhaled nitric oxide compared to those who were managed initially with invasive MV. ICU and hospital length of stay were similar between NIV patients and invasive MV patients. The use of NIV was not independently associated with 90‐day mortality (propensity score‐adjusted odds ratio 0.61, 95% CI [0.23, 1.60] P = 0.27). CONCLUSIONS: In patients with MERS and acute hypoxemic respiratory failure, NIV failure was very high. The use of NIV was not associated with improved outcomes. url: https://www.ncbi.nlm.nih.gov/pubmed/30884185/ doi: 10.1111/irv.12635 id: cord-330704-4piesfxu author: Avdeev, Sergey N. title: Noninvasive ventilation for acute hypoxemic respiratory failure in patients with COVID-19 date: 2020-10-01 words: 1728 sentences: 107 pages: flesch: 53 cache: ./cache/cord-330704-4piesfxu.txt txt: ./txt/cord-330704-4piesfxu.txt summary: MATERIALS & METHODS: In this retrospective cohort study, patients with confirmed diagnosis of COVID-19 and AHRF receiving NIV in general wards were recruited from two university-affiliated hospitals. However, there were major concerns that HFNC or NIV may create risks for health care workers (HCWs) because of SARS-CoV-2 transmission via aerosols [6] while the data on the efficacy of noninvasive modalities in COVID-19-associated AHRF are still limited [6] [7] [8] . This study suggests that the use of NIV is feasible in acute hypoxemic respiratory failure in patients with COVID-19 outside intensive care unit and can be considered as an effective means to improve oxygenation in patients not responding to conventional oxygen therapy. In summary, we have shown that NIV is feasible in patients with COVID-19 with acute hypoxemic respiratory failure outside the intensive care unit, and it can be considered as a valuable option for the management of AHRF in these patients. abstract: AIM: Noninvasive ventilation (NIV) is known to reduce intubation in patients with acute hypoxemic respiratory failure (AHRF) [1]. We aimed to assess the outcomes of NIV application in COVID-19 patients with AHRF. MATERIALS & METHODS: In this retrospective cohort study, patients with confirmed diagnosis of COVID-19 and AHRF receiving NIV in general wards were recruited from two university-affiliated hospitals. Demographic, clinical, and laboratory data were recorded at admission. The failure of NIV was defined as intubation or death during the hospital stay. RESULTS: Between April 8 and June 10, 2020, 61 patients were enrolled into the final cohort. NIV was successful in 44 out of 61 patients (72.1%), 17 patients who failed NIV therapy were intubated, and among them 15 died. Overall mortality rate was 24.6%. Patients who failed NIV were older, and had higher respiratory rate, PaCO(2), D-dimer levels before NIV and higher minute ventilation and ventilatory ratio on the 1-st day of NIV. No healthcare workers were infected with SARS-CoV-2 during the study period. CONCLUSIONS: NIV is feasible in patients with COVID-19 and AHRF outside the intensive care unit, and it can be considered as a valuable option for the management of AHRF in these patients. url: https://www.ncbi.nlm.nih.gov/pubmed/33067061/ doi: 10.1016/j.ajem.2020.09.075 id: cord-355450-v3eh1rtk author: Boattini, Matteo title: Influenza and respiratory syncytial virus infections in the oldest-old continent date: 2020-06-27 words: 2668 sentences: 125 pages: flesch: 42 cache: ./cache/cord-355450-v3eh1rtk.txt txt: ./txt/cord-355450-v3eh1rtk.txt summary: Influenza and respiratory syncytial virus (RSV) infections are associated with high rate of morbidity, mortality, and an important burden on healthcare systems worldwide, especially among elderly patients [1] [2] [3] [4] [5] [6] . Especially in epidemiological research, oldest-old patients are considered to be a part of the wider age group of the elderly (≥ 65 years old), and there is limited published evidence about predictors of severity of illness and mortality in viral infections, such as caused by influenza and RSV. The aim of this study was to describe the clinical features of an oldest-old population admitted with influenza and/or RSV infections in three southern European hospitals over two consecutive winter seasons and identify predictors of pneumonia, non-invasive ventilation (NIV), and in-hospital death (IHD). Moreover, in our study, hospital-acquired influenza and/or RSV infections were not identified as predictors of pneumonia, use of NIV, and IHD for patients aged 65 years and older, moving away from evidence available so far [9, 10] . abstract: SARS-CoV-2 dramatically revealed the sudden impact of respiratory viruses in our lives. Influenza and respiratory syncytial virus (RSV) infections are associated with high rates of morbidity, mortality, and an important burden on healthcare systems worldwide, especially in elderly patients. The aim of this study was to identify severity predictors in the oldest-old admitted with influenza and/or RSV infections. This is a multicenter, retrospective study of all oldest-old patients (≥ 85 years old) admitted for laboratory-confirmed influenza and/or RSV infection in three tertiary hospitals in Portugal, Italy, and Cyprus over two consecutive winter seasons. The outcomes included the following: pneumonia on infection presentation, use of non-invasive ventilation (NIV), and in-hospital death (IHD). The association with possible predictors, including clinical features and type of virus infection, was assessed using uni- and multivariable analyses. A total of 251 oldest-old patients were included in the study. Pneumonia was evident in 32.3% (n = 81). NIV was implemented in 8.8% (n = 22), and IHD occurred in 13.9% (n = 35). Multivariable analyses revealed that chronic obstructive pulmonary disease (COPD) or asthma was associated with pneumonia (OR 1.86; 95% CI 1.02–3.43; p = 0.045). COPD or asthma (OR 4.4; 95% CI 1.67–11.6; p = 0.003), RSV (OR 3.12; 95% CI 1.09–8.92; p = 0.023), and influenza B infections (OR 3.77; 95% CI 1.06–13.5; p = 0.041) were associated with NIV use, respectively, while chronic kidney disease was associated with IHD (OR 2.50; 95% CI 1.14–5.51; p = 0.023). Among the oldest-old, chronic organ failure, such as COPD or asthma, and CKD predicted pneumonia and IHD, respectively, beyond the importance of viral virulence itself. These findings could impact on public health policies, such as fostering influenza immunization campaigns, home-based care programs, and end-of-life care. Filling knowledge gaps is crucial to set priorities and advise on transition model of care that best fits the oldest-old. url: https://doi.org/10.1007/s10096-020-03959-9 doi: 10.1007/s10096-020-03959-9 id: cord-335078-z7k59k8o author: Burton-Papp, Helmi C. title: Conscious prone positioning during non-invasive ventilation in COVID-19 patients: experience from a single centre date: 2020-07-31 words: 3765 sentences: 182 pages: flesch: 43 cache: ./cache/cord-335078-z7k59k8o.txt txt: ./txt/cord-335078-z7k59k8o.txt summary: In our cohort of 20 COVID-19 patients with moderate acute hypoxic respiratory failure, prone positioning with non-invasive ventilation resulted in improved oxygenation. Here we build on this literature offering an examination of changes in oxygenation, as measured by PaO 2 /FiO 2 , across multiple episodes of prone positioning in conscious patients, with moderate to severe hypoxia, undergoing non-invasive ventilation following admission to the intensive care unit for advanced respiratory support. Although there is only limited data available on the effectiveness of non-invasive ventilation (NIV) in COVID-19, early provision of NIV in moderate to severe acute hypoxic respiratory failure is associated with reduced ICU mortality and intubation rate 12 . This is a retrospective report on a subgroup of 20 patients with severe COVID-19 who were able to self-prone while receiving non-invasive ventilation in the ICU, among a grand total of 81 patients admitted to the ICU during the study period.The primary outcome reported by the authors is change in PaO2/FiO2 ratio while in prone position. abstract: Critically ill patients admitted to hospital following SARS-CoV-2 infection often experience hypoxic respiratory failure and a proportion require invasive mechanical ventilation to maintain adequate oxygenation. The combination of prone positioning and non-invasive ventilation in conscious patients may have a role in improving oxygenation. The purpose of this study was to assess the effect of prone positioning in spontaneously ventilating patients receiving non-invasive ventilation admitted to the intensive care. Clinical data of 81 patients admitted with COVID 19 pneumonia and acute hypoxic respiratory failure were retrieved from electronic medical records and examined. Patients who had received prone positioning in combination with non-invasive ventilation were identified. A total of 20 patients received prone positioning in conjunction with non-invasive ventilation. This resulted in improved oxygenation as measured by a change in PaO (2)/FiO (2) (P/F) ratio of 28.7 mmHg while prone, without significant change in heart rate or respiratory rate. Patients on average underwent 5 cycles with a median duration of 3 hours. There were no reported deaths, 7 of the 20 patients (35%) failed non-invasive ventilation and subsequently required intubation and mechanical ventilation. In our cohort of 20 COVID-19 patients with moderate acute hypoxic respiratory failure, prone positioning with non-invasive ventilation resulted in improved oxygenation. Prone positioning with non-invasive ventilation may be considered as an early therapeutic intervention in COVID-19 patients with moderate acute hypoxic respiratory failure. url: https://www.ncbi.nlm.nih.gov/pubmed/33110499/ doi: 10.12688/f1000research.25384.1 id: cord-346565-vsgbmxzv author: Cascella, Marco title: Rapid and Impressive Response to a Combined Treatment with Single-Dose Tocilizumab and NIV in a Patient with COVID-19 Pneumonia/ARDS date: 2020-07-27 words: 3855 sentences: 200 pages: flesch: 48 cache: ./cache/cord-346565-vsgbmxzv.txt txt: ./txt/cord-346565-vsgbmxzv.txt summary: Treatment of acute respiratory distress syndrome (ARDS) due to COVID-19 pneumonia (CARDS) represents a clinical challenge, requiring often invasive mechanical ventilation (IMV). Despite that at the beginning of the pandemic, early invasive mechanical ventilation was indicated as the optimal strategy for CARDS management, in COVID-19 pneumonia the clinical picture of severe hypoxemia contrasted with the typical ARDS respiratory mechanics. Clinical experience, for example, suggested that non-invasive ventilation (NIV) has a role of primary importance in the management of CARDS as it can improve oxygenation, limiting the work of the respiratory muscles and preventing the onset of the patient self-inflicted lung injury (P-SILI) [2] . In this setting, adding the prone position to NIV could improve oxygenation, decrease respiratory effort, reducing self-induced lung injury, and avoid the need of intubation and invasive ventilation, which could be particularly useful in the case of reduced availability of intensive care unit (ICU) beds [4] [5] [6] . abstract: Treatment of acute respiratory distress syndrome (ARDS) due to COVID-19 pneumonia (CARDS) represents a clinical challenge, requiring often invasive mechanical ventilation (IMV). Since the pathogenesis of CARDS it probably involves a direct viral attack to pulmonary and endothelium cells, and immune-mediated inflammation with dysfunctional coagulation, it was suggested to interfere with interleukin-6 (IL-6) activity by using the IL-6 receptor monoclonal antibody tocilizumab (TCZ). We reported the case of a 54-year-old 100 kg male COVID-19 patient (BMI 29) with severe respiratory insufficiency featuring dyspnea and hypoxia (SpO(2) 89% on room; PaO(2) 53 mmHg). Despite treatment with antiviral and non-invasive ventilation (NIV), after 24 h there was a progressive worsening of clinical conditions with higher fever (40 °C), increased dyspnea, and hypoxia (PaO(2)/FiO(2) or P/F ratio of 150). The patient was at the limit to be sedated and intubated for IMV. He was treated with tocilizumab (8 mg/Kg i.v., single shot 800 mg) and NIV in the prone positioning. After only 96 h, the clinical, laboratory, and imaging findings showed incredible improvement. There was an important gain in oxygenation (P/F 300), a decrease of C-reactive protein values, and a decrease of the fever. Both the neutrophil-to-lymphocyte ratio (NLR) and the derived NLR ratio dropped down to 44%. Chest imaging confirmed the favorable response. This case suggested that for CARDS management efforts are needed for reducing its underlying inflammatory processes. Through a multiprofessional approach, the combination of IL-6-targeting therapies with calibrated ventilatory strategies may represent a winning strategy for improving outcomes. url: https://doi.org/10.3390/medicina56080377 doi: 10.3390/medicina56080377 id: cord-313816-7d8x7fjp author: Cinesi Gómez, C. title: Clinical Consensus Recommendations Regarding Non-Invasive Respiratory Support in the Adult Patient with Acute Respiratory Failure Secondary to SARS-CoV-2 infection date: 2020-05-07 words: 2984 sentences: 172 pages: flesch: 54 cache: ./cache/cord-313816-7d8x7fjp.txt txt: ./txt/cord-313816-7d8x7fjp.txt summary: title: Clinical Consensus Recommendations Regarding Non-Invasive Respiratory Support in the Adult Patient with Acute Respiratory Failure Secondary to SARS-CoV-2 infection The document provides clinical recommendations for the noninvasive respiratory support (noninvasive ventilation, high flow oxygen therapy with nasal cannula) in any patient with suspected or confirmed presentation of COVID-19 with acute respiratory failure. It includes a more detailed description of the recommendations for the use of non-invasive respiratory support (NIRS) in the management of acute respiratory failure (ARF) secondary to infection by the new SARS-CoV-2 coronavirus that causes the disease called COVID-19 that is intended to supplement the regularly updated recommendations issued by the Ministry of Health, Consumer Affairs and Social Welfare (MH) 1,2 . abstract: Abstract Coronavirus disease 2019 (COVID-19) is a respiratory tract infection caused by a newly emergent coronavirus, that was first recognized in Wuhan, China, in December 2019. Currently, the World Health Organization (WHO) has defined the infection as a global pandemic and there is a health and social emergency for the management of this new infection. While most people with COVID-19 develop only mild or uncomplicated illness, approximately 14% develop severe disease that requires hospitalization and oxygen support, and 5% require admission to an intensive care unit. In severe cases, COVID-19 can be complicated by the acute respiratory distress syndrome (ARDS), sepsis and septic shock, and multiorgan failure. This consensus document has been prepared on evidence-informed guidelines developed by a multidisciplinary panel of health care providers from four Spanish scientific societies (Spanish Society of Intensive Care Medicine [SEMICYUC], Spanish Society of Pulmonologists [SEPAR], Spanish Society of Emergency [SEMES], Spanish Society of Anesthesiology, Reanimation, and Pain [SEDAR]) with experience in the clinical management of patients with COVID-19 and other viral infections, including SARS, as well as sepsis and ARDS. The document provides clinical recommendations for the noninvasive respiratory support (noninvasive ventilation, high flow oxygen therapy with nasal cannula) in any patient with suspected or confirmed presentation of COVID-19 with acute respiratory failure. This consensus guidance should serve as a foundation for optimized supportive care to ensure the best possible chance for survival and to allow for reliable comparison of investigational therapeutic interventions as part of randomized controlled trials. url: https://api.elsevier.com/content/article/pii/S234119292030069X doi: 10.1016/j.redare.2020.05.001 id: cord-017786-kfl6xt31 author: Curiel-Balsera, Emilio title: Guidelines for Health Organizations: European Perspectives and Experience in Pandemics date: 2013-05-29 words: 1648 sentences: 93 pages: flesch: 43 cache: ./cache/cord-017786-kfl6xt31.txt txt: ./txt/cord-017786-kfl6xt31.txt summary: Recommendations for droplets include patient isolation with protective measures for health care providers and other patients, use of double-circuit tubes and special fi lters for nonrebreathing devices, minimization of leaks, preferably fullface mask or helmet interfaces, avoidance of heated humidifi ers, and disposing of mask and tubes after use according to routine infection control procedures [ 7 ] . The document states that: …noninvasive mechanical ventilation cannot be considered a technique of choice in patients with acute respiratory distress syndrome, but could be useful in experienced centers and in cases of respiratory failure associated with exacerbation of chronic obstructive pulmonary disease or heart failure. • Noninvasive mechanical ventilation cannot be considered a technique of choice in patients with ARDS but could be useful in experienced centers and in cases of respiratory failure associated with exacerbation of chronic obstructive pulmonary disease or heart failure. abstract: In Europe, the rate of noninvasive ventilation (NIV) use in intensive care units (ICUs) is about 35 % for ventilated patients and higher (roughly 60 %) in respiratory ICUs or emergency departments. In North America, this form of ventilation is begun most often in emergency departments (EDs), most patients being transferred to the ICU or step-down units in hospitals with such facilities. This low rate of use in some hospitals is related to scarce knowledge on or experience with this technique, insufficient technical equipment, and inadequate funding. Despite these limitations, NIV is increasingly being used outside traditional and respiratory ICUs, including EDs, postsurgical recovery rooms, cardiology, neurology, and oncology wards, and palliative care units. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122448/ doi: 10.1007/978-3-7091-1496-4_41 id: cord-267537-akzydy7l author: Dang, Ha V. title: An antibody against the F glycoprotein inhibits Nipah and Hendra virus infections date: 2019-09-30 words: 9566 sentences: 545 pages: flesch: 52 cache: ./cache/cord-267537-akzydy7l.txt txt: ./txt/cord-267537-akzydy7l.txt summary: Cryo-electron microscopy, triggering and fusion studies show the antibody binds to a prefusion-specific quaternary epitope, conserved in NiV F and HeV F glycoproteins, and prevents membrane fusion and viral entry. To elucidate the mechanism of 5B3-mediated neutralization of NiV and HeV, we determined a cryo-EM structure of a stabilized NiV F ectodomain trimer in complex with the 5B3 antibody Fab fragment at 3.5 Å resolution (Fig. 2a,b , Table 1 and Extended Data 1). To further study the mechanism of action of 5B3/h5B3.1 in the context of a full-length, membrane-embedded F glycoprotein, we carried out cell-cell fusion assays in the presence of varying concentrations of mAbs. We observed that 5B3 and h5B3.1 prevented NiV F-and HeV F-mediated membrane fusion in a concentration-dependent manner, consistent with the expectation that trapping F in the prefusion conformation actually resulted in inhibition of membrane fusion (Figs. abstract: Nipah virus (NiV) and Hendra virus (HeV) are zoonotic henipaviruses (HNVs) responsible for outbreaks of encephalitis and respiratory illness with fatality rates of 50–100%. No vaccines or licensed therapeutics currently exist to protect humans against NiV or HeV. HNVs enter host cells by fusing the viral and cellular membranes via the concerted action of the attachment (G) and fusion (F) glycoproteins, the main targets of the humoral immune response. Here, we describe the isolation and humanization of a potent monoclonal antibody cross-neutralizing NiV and HeV. Cryo-electron microscopy, triggering and fusion studies show the antibody binds to a prefusion-specific quaternary epitope, conserved in NiV F and HeV F glycoproteins, and prevents membrane fusion and viral entry. This work supports the importance of the HNV prefusion F conformation for eliciting a robust immune response and paves the way for using this antibody for prophylaxis and post-exposure therapy with NiV- and HeV-infected individuals. url: https://www.ncbi.nlm.nih.gov/pubmed/31570878/ doi: 10.1038/s41594-019-0308-9 id: cord-303292-iheq50ub author: De Jong, Audrey title: How to ventilate obese patients in the ICU date: 2020-10-23 words: 7496 sentences: 355 pages: flesch: 41 cache: ./cache/cord-303292-iheq50ub.txt txt: ./txt/cord-303292-iheq50ub.txt summary: Regarding mechanical ventilation in patients with and without acute respiratory distress syndrome (ARDS), low tidal volume (6 ml/kg of predicted body weight) and moderate to high positive end-expiratory pressure (PEEP), with careful recruitment maneuver in selected patients, are advised. During invasive mechanical ventilation, patients with obesity are more prone to lung collapse and require higher PEEP to avoid it; low V T is calculated on predicted body weight. In a randomized controlled trial of the same team comparing HFNC to standard oxygen [87] in high-risk non-hypercapnic patients including 22% of patients with obesity, the study was stopped due to low recruitment after 155 patients, without any difference in extubation failure rate found between the two groups. PBW predicted body weight, PEEP positive end-expiratory pressure, ARDS acute respiratory distress syndrome, ECMO extracorporeal membrane oxygenation, CPAP continuous positive airway pressure, NIV noninvasive ventilation, HFNC high-flow nasal cannula oxygen patients. abstract: Obesity is an important risk factor for major complications, morbidity and mortality related to intubation procedures and ventilation in the intensive care unit (ICU). The fall in functional residual capacity promotes airway closure and atelectasis formation. This narrative review presents the impact of obesity on the respiratory system and the key points to optimize airway management, noninvasive and invasive mechanical ventilation in ICU patients with obesity. Non-invasive strategies should first optimize body position with reverse Trendelenburg position or sitting position. Noninvasive ventilation (NIV) is considered as the first-line therapy in patients with obesity having a postoperative acute respiratory failure. Positive pressure pre-oxygenation before the intubation procedure is the method of reference. The use of videolaryngoscopy has to be considered by adequately trained intensivists, especially in patients with several risk factors. Regarding mechanical ventilation in patients with and without acute respiratory distress syndrome (ARDS), low tidal volume (6 ml/kg of predicted body weight) and moderate to high positive end-expiratory pressure (PEEP), with careful recruitment maneuver in selected patients, are advised. Prone positioning is a therapeutic choice in severe ARDS patients with obesity. Prophylactic NIV should be considered after extubation to prevent re-intubation. If obesity increases mortality and risk of ICU admission in the overall population, the impact of obesity on ICU mortality is less clear and several confounding factors have to be taken into account regarding the “obesity ICU paradox”. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00134-020-06286-x) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pubmed/33095284/ doi: 10.1007/s00134-020-06286-x id: cord-290684-3f6prlqy author: Duan, Jun title: Use of high-flow nasal cannula and noninvasive ventilation in patients with COVID-19: A multicenter observational study date: 2020-07-29 words: 2818 sentences: 185 pages: flesch: 62 cache: ./cache/cord-290684-3f6prlqy.txt txt: ./txt/cord-290684-3f6prlqy.txt summary: title: Use of high-flow nasal cannula and noninvasive ventilation in patients with COVID-19: A multicenter observational study BACKGROUND: The use of high-flow nasal cannula (HFNC) and noninvasive ventilation (NIV) in patients with COVID-19 is debated. CONCLUSIONS: In critically ill patients with COVID-19 who used HFNC and NIV as first-line therapy, the duration of HFNC + NIV, intubation rate and mortality did not differ between two groups. The Asian Critical Care Clinical Trials Group has suggested that the HFNC and NIV only can be used in COVID-19 patients with mild acute respiratory distress syndrome (ARDS) [21] . abstract: BACKGROUND: The use of high-flow nasal cannula (HFNC) and noninvasive ventilation (NIV) in patients with COVID-19 is debated. METHODS: This study was performed in four hospitals of China from January to March 2020. We retrospectively enrolled 23 and 13 COVID-19 patients who used HFNC and NIV as first-line therapy, respectively. RESULTS: Among the 23 patients who used HFNC as first-line therapy, 10 experienced HFNC failure and used NIV as rescue therapy. Among the 13 patients who used NIV as first-line therapy, one (8%) used HFNC as rescue therapy due to NIV intolerance. The duration of HFNC + NIV (median 7.1, IQR: 3.5–12.2 vs. 7.3, IQR: 5.3–10.0 days), intubation rate (17% vs. 15%) and mortality (4% vs. 8%) did not differ between patients who used HFNC and NIV as first-line therapy. In total cohorts, 6 (17%) patients received intubation. Time from initiation of HFNC or NIV to intubation was 8.4 days (IQR: 4.4–18.5). And the time from initiation of HFNC or NIV to termination in patients without intubation was 7.1 days (IQR: 3.9–10.3). Among all the patients, C-reactive protein was independently associated with intubation (OR = 1.04, 95% CI: 1.01–1.07). In addition, no medical staff got nosocomial infection who participated in HFNC and NIV management. CONCLUSIONS: In critically ill patients with COVID-19 who used HFNC and NIV as first-line therapy, the duration of HFNC + NIV, intubation rate and mortality did not differ between two groups. And no medical staff got nosocomial infection during this study. url: https://www.sciencedirect.com/science/article/pii/S0735675720306665?v=s5 doi: 10.1016/j.ajem.2020.07.071 id: cord-016897-t71f10kv author: Flores, Marco V. title: Preventing Airborne Disease Transmission: Implications for Patients During Mechanical Ventilation date: 2013-05-29 words: 3661 sentences: 196 pages: flesch: 46 cache: ./cache/cord-016897-t71f10kv.txt txt: ./txt/cord-016897-t71f10kv.txt summary: We discuss the risk of transmitting these procedures and the strategies for mechanical ventilation in future airborne epidemics with special consideration given to the issue of protecting health care workers (HCWs). In contrast to the situation regarding severe acute respiratory syndrome (SARS) or tuberculosis prevention in HCWs, little attention has been given to the importance of HCWs personal protective equipment (PPE) (gowns, gloves, masks) for prevention and management of infl uenza. There is also potential for NIV to reduce the need for intubation in patients with infl uenza pneumonia or chronic respiratory disease, facilitate extubation, and widen the provision of ventilator support outside the intensive care unit (ICU). Evaluation of droplet dispersion during non-invasive ventilation, oxygen therapy, nebulizer treatment and chest physiotherapy in clinical practice: implications for management of pandemic infl uenza and other airbone infections Aerosol generating procedures and risk of transmission of acute respiratory infections to healthcare workers: a systematic review abstract: The organisms causing respiratory infections such as influenza are spread in droplets or aerosols or by direct or indirect contact with contaminated surfaces. Certain medical procedures have been termed aerosol generating because they are associated with high or augmented inspiratory and expiratory flows, which can increase microbial dissemination. Invasive ventilation maneuvers and noninvasive ventilation (NIV) fall into that category. We discuss the risk of transmitting these procedures and the strategies for mechanical ventilation in future airborne epidemics with special consideration given to the issue of protecting health care workers (HCWs). url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121330/ doi: 10.1007/978-3-7091-1496-4_34 id: cord-344641-rog2h4g7 author: Franco, Cosimo title: Feasibility and clinical impact of out-of-ICU non-invasive respiratory support in patients with COVID-19 related pneumonia date: 2020-08-03 words: 3700 sentences: 163 pages: flesch: 49 cache: ./cache/cord-344641-rog2h4g7.txt txt: ./txt/cord-344641-rog2h4g7.txt summary: INTRODUCTION: The Coronavirus 2(SARS-CoV-2) outbreak spread rapidly in Italy and the lack of intensive care unit(ICU) beds soon became evident, forcing the application of noninvasive respiratory support(NRS) outside the ICU, raising concerns over staff contamination. Data were collected including medication, mode and usage of the NRS (i.e. high-flow nasal cannula (HFNC), continuous positive airway pressure (CPAP), noninvasive ventilation(NIV)), length of stay in hospital, endotracheal intubation(ETI) and deaths. Variables recorded for each patient were obtained for the period from March 1 st until May 10 th 2020 and included the following: demographics (age, sex), comorbidities (type and number), respiratory condition at admission (respiratory rate (RR), PaO 2 /FiO 2 ratio), medications (type of drugs prescribed), mode and usage of the NRS (ventilatory settings for NIV and CPAP, and flow rate for HFNC), and stay in hospital (days). abstract: INTRODUCTION: The Coronavirus 2(SARS-CoV-2) outbreak spread rapidly in Italy and the lack of intensive care unit(ICU) beds soon became evident, forcing the application of noninvasive respiratory support(NRS) outside the ICU, raising concerns over staff contamination. We aimed to analyse the safety of the hospital staff, the feasibility, and outcomes of NRS applied to patients outside the ICU. METHODS: In this observational study, data from 670 consecutive patients with confirmed COVID-19 referred to the Pulmonology Units in nine hospitals between March 1st and May 10th,2020 were analysed. Data were collected including medication, mode and usage of the NRS (i.e. high-flow nasal cannula (HFNC), continuous positive airway pressure (CPAP), noninvasive ventilation(NIV)), length of stay in hospital, endotracheal intubation(ETI) and deaths. RESULTS: Forty-two health-care workers (11.4%) tested positive for infection, but only three of them required hospitalisation. Data are reported for all patients (69.3% male), whose mean age was 68 (sd 13) years. The PaO(2)/FiO(2) ratio at baseline was 152±79, and the majority of patients (49.3%) were treated with CPAP. The overall unadjusted 30-day mortality rate was 26.9% with 16%, 30%, and 30%, while the total ETI rate was 27% with 29%, 25% and 28%, for HFNC, CPAP, and NIV, respectively, and the relative probability to die was not related to the NRS used after adjustment for confounders. ETI and length of stay were not different among the groups. Mortality rate increased with age and comorbidity class progression. CONCLUSIONS: The application of NRS outside the ICU is feasible and associated with favourable outcomes. Nonetheless, it was associated with a risk of staff contamination. url: https://doi.org/10.1183/13993003.02130-2020 doi: 10.1183/13993003.02130-2020 id: cord-010669-rg2p3kal author: Fubini, PE title: Prehospital reversal of profound respiratory acidosis and hypercapnic coma by non-invasive ventilation: a report of two cases date: 2020-05-07 words: 2005 sentences: 97 pages: flesch: 45 cache: ./cache/cord-010669-rg2p3kal.txt txt: ./txt/cord-010669-rg2p3kal.txt summary: BACKGROUND: In chronic obstructive pulmonary disease (COPD) patients with acute respiratory failure (ARF), non-invasive ventilation (NIV) is generally recommended and has proven its benefits by reducing endotracheal intubation (ETI) rates, intensive care unit (ICU) admissions, complications, and mortality. CASE PRESENTATION: We report two cases of ARF in COPD patients who were successfully treated by NIV in prehospital setting and avoided ETI despite contraindications (altered mental status with a Glasgow Coma Scale < 8) and failure risk factors (severe respiratory acidosis with pH < 7.25). Acute respiratory failure (ARF) in chronic obstructive pulmonary disease (COPD) patients is a well-known indication for non-invasive ventilation (NIV) trial [1] . We report here two cases of ARF in COPD patients with severe respiratory acidosis and hypercapnic coma successfully treated by NIV in the prehospital setting. In conclusion, for COPD patients presenting ARF, NIV trial could be considered even when relative contraindications such as an altered level of consciousness or a severe respiratory acidosis are present. abstract: BACKGROUND: In chronic obstructive pulmonary disease (COPD) patients with acute respiratory failure (ARF), non-invasive ventilation (NIV) is generally recommended and has proven its benefits by reducing endotracheal intubation (ETI) rates, intensive care unit (ICU) admissions, complications, and mortality. Choosing between immediate ETI or NIV trial is often difficult when such patients present with an altered mental status. Some guidelines recommend avoiding NIV when consciousness is impaired given the risk of aspiration, and some authors suggest that a pH < 7.25 is highly predictive of NIV failure. Though clinical response to a well-adjusted NIV treatment can be both swift and spectacular, these contraindications probably encourage physicians to proceed to immediate ETI. Some studies indeed report that NIV was not even considered in as many as 60% of patients who might have benefited from this therapy, though ETI related complications might have been avoided had NIV been successfully applied. CASE PRESENTATION: We report two cases of ARF in COPD patients who were successfully treated by NIV in prehospital setting and avoided ETI despite contraindications (altered mental status with a Glasgow Coma Scale < 8) and failure risk factors (severe respiratory acidosis with pH < 7.25). CONCLUSION: In COPD patients presenting ARF, NIV trial could be considered even when relative contraindications such as an altered level of consciousness or a severe respiratory acidosis are present. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206709/ doi: 10.1186/s12245-020-00284-y id: cord-352059-1bjskqyg author: Gupta, Nivedita title: Laboratory preparedness for SARS-CoV-2 testing in India: Harnessing a network of Virus Research & Diagnostic Laboratories date: 2020-04-28 words: 4174 sentences: 224 pages: flesch: 53 cache: ./cache/cord-352059-1bjskqyg.txt txt: ./txt/cord-352059-1bjskqyg.txt summary: The Indian Council of Medical Research (ICMR)-National Institute of Virology (NIV), Pune, which is the apex laboratory for viral diagnosis and research in India, optimized the conventional and real-time PCR assays targeting different genomic regions of SARS-CoV-2 and initiated testing of suspected cases. Before initiating testing of clinical specimens from suspected cases of SARS-CoV-2, each VRDL shared results from the rRT-PCR runs performed with positive and negative controls with the apex laboratory (NIV, Pune). Expansion of testing capabilities and selection of testing laboratories for SARS-CoV-2: Following the increase in the load of screening samples from suspected cases with symptoms and travel history to China or asymptomatic persons with travel history to Wuhan after January 15, 2020, it was decided that strategically located VRDLs needed to start testing for SARS-CoV-2 in addition to Thereafter, NCDC, Delhi, initiated independent testing; however, results were shared with ICMR on a daily basis. abstract: BACKGROUND & OBJECTIVES: An outbreak of respiratory illness of unknown aetiology was reported from Hubei province of Wuhan, People's Republic of China, in December 2019. The outbreak was attributed to a novel coronavirus (CoV), named as severe acute respiratory syndrome (SARS)-CoV-2 and the disease as COVID-19. Within one month, cases were reported from 25 countries. In view of the novel viral strain with reported high morbidity, establishing early countrywide diagnosis to detect imported cases became critical. Here we describe the role of a countrywide network of VRDLs in early diagnosis of COVID-19. METHODS: The Indian Council of Medical Research (ICMR)-National Institute of Virology (NIV), Pune, established screening as well as confirmatory assays for SARS-CoV-2. A total of 13 VRDLs were provided with the E gene screening real-time reverse transcription-polymerase chain reaction (rRT-PCR) assay. VRDLs were selected on the basis of their presence near an international airport/seaport and their past performance. The case definition for testing included all individuals with travel history to Wuhan and symptomatic individuals with travel history to other parts of China. This was later expanded to include symptomatic individuals returning from Singapore, Japan, Hong Kong, Thailand and South Korea. RESULTS: Within a week of standardization of the test at NIV, all VRDLs could initiate testing for SARS-CoV-2. Till February 29, 2020, a total of 2,913 samples were tested. This included both 654 individuals quarantined in the two camps and others fitting within the case definition. The quarantined individuals were tested twice - at days 0 and 14. All tested negative on both occasions. Only three individuals belonging to different districts in Kerala were found to be positive. INTERPRETATION & CONCLUSIONS: Sudden emergence of SARS-CoV-2 and its potential to cause a pandemic posed an unsurmountable challenge to the public health system of India. However, concerted efforts of various arms of the Government of India resulted in a well-coordinated action at each level. India has successfully demonstrated its ability to establish quick diagnosis of SARS-CoV-2 at NIV, Pune, and the testing VRDLs. url: https://www.ncbi.nlm.nih.gov/pubmed/32242875/ doi: 10.4103/ijmr.ijmr_594_20 id: cord-010850-zj6k7wz9 author: Holbird, Samantha title: Noninvasive ventilation for pediatric interfacility transports: a retrospective study date: 2020-05-13 words: 1978 sentences: 113 pages: flesch: 45 cache: ./cache/cord-010850-zj6k7wz9.txt txt: ./txt/cord-010850-zj6k7wz9.txt summary: BACKGROUND: To characterize pediatric patients supported with continuous positive airway pressure and bilevel positive airway pressure (CPAP/BiPAP) or high-flow nasal cannula (HFNC) during interfacility transport (IFT). Pediatric patients aged 28 days to < 17 years, who required IFT between January 2017 and December 2018, were identified through a transport registry and were included in the study. The objectives of this retrospective chart review study were to characterize pediatric patients requiring IFTs and NIV and to examine their clinical outcomes, including the need for airway instrumentation. A total of 120 patients (Table 1 ) on NIV or HFNC for IFT were studied (26.7% of transport cohort), but 2 had incomplete records and were excluded from analysis. Our crude IFT data showed that in 2019, 62% of patients requiring respiratory support were initiated on NIV; in 2014, it was less than 10%. abstract: BACKGROUND: To characterize pediatric patients supported with continuous positive airway pressure and bilevel positive airway pressure (CPAP/BiPAP) or high-flow nasal cannula (HFNC) during interfacility transport (IFT). METHODS: A retrospective study with a provincial pediatric transport team from a tertiary hospital pediatric intensive care unit. Pediatric patients aged 28 days to < 17 years, who required IFT between January 2017 and December 2018, were identified through a transport registry and were included in the study. RESULTS: A total of 118 (26.7%) patients received CPAP/BIPAP or HFNC support for IFT. The most common respiratory diagnosis was bronchiolitis (46%). These patients were placed on respiratory support, 31.4 minutes after the transport team’s arrival. None required intubation during their IFT, despite mean transport times of 163 minutes. CONCLUSIONS: This study may provide important information for programs with large catchment areas, in which large distances and transport times should not be barriers to NIV implementation. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222886/ doi: 10.1007/s12519-020-00363-3 id: cord-011222-7aha5b07 author: Huang, Cheng-Chi title: The application of non-invasive and invasive mechanical ventilation in the first episode of acute respiratory failure date: 2020-03-30 words: 3398 sentences: 163 pages: flesch: 49 cache: ./cache/cord-011222-7aha5b07.txt txt: ./txt/cord-011222-7aha5b07.txt summary: NIV use was frequently observed in old-age persons (aOR 3.99, 95% CI 3.06–5.21 for those aged ≥ 80 years), women (aOR 1.33, 95% CI 1.18–1.50), patients admitted to a high-level hospital (aOR 1.95, 95% CI 1.63−2.34 for those admitted to a medical center), and patients with a higher Charlson comorbidity index (CCI, aOR 1.38−1.66 for those CCI ≥ 2). In addition, patients with chronic pulmonary disease, cancer, and congestive heart failure were predominant in NIV users and were significantly associated with NIV use. Patients comorbid with a medical history of cancer (aOR 2.57, 95% CI 2.23−2.97), chronic pulmonary disease (aOR 2.24, 95% CI 1.97−2.55), and congestive heart failure (aOR 1.27, 95% CI 1.08−1.49) had a significantly higher NIV choice compared to that of individuals without those medical history. abstract: Acute respiratory failure (RF) is a life-threatening syndrome. This study investigated the application of two major clinical strategies, non-invasive mechanical ventilation (NIV) and invasive mechanical ventilation (IMV), in the first episode of acute RF. Data from the longitudinal health insurance database, which included 1,000,000 insured citizens, were used. The NIV group consisted of 1201 patients and the IMV group consisted of 16,072 patients. Chi-square test and t test were applied to determine the differences in categorical and continuous variables. Further analysis was performed by using univariate and multivariable logistic regression and Poisson regression. There was a significant increase of 733% in the number of NIV users from 2000 to 2012. NIV use was frequently observed in old-age persons (aOR 3.99, 95% CI 3.06–5.21 for those aged ≥ 80 years), women (aOR 1.33, 95% CI 1.18–1.50), patients admitted to a high-level hospital (aOR 1.95, 95% CI 1.63−2.34 for those admitted to a medical center), and patients with a higher Charlson comorbidity index (CCI, aOR 1.38−1.66 for those CCI ≥ 2). In addition, patients with chronic pulmonary disease, cancer, and congestive heart failure were predominant in NIV users and were significantly associated with NIV use. Overall, the use of NIV has markedly increased over the past few years. Persons of advanced age, women, patients admitted to a high-level hospital, and patients with multiple comorbidities were associated with more frequent NIV use. Chronic pulmonary disease, cancer, and congestive heart failure were most important comorbidities for NIV use. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11739-020-02315-1) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223827/ doi: 10.1007/s11739-020-02315-1 id: cord-016744-jzhuq4te author: Hui, David S. C. title: Noninvasive Mechanical Ventilation: Models to Assess Air and Particle Dispersion date: 2013-05-29 words: 3687 sentences: 166 pages: flesch: 49 cache: ./cache/cord-016744-jzhuq4te.txt txt: ./txt/cord-016744-jzhuq4te.txt summary: particles generated during tidal breathing [ 8 ] , NIV may disperse potentially infected aerosols, especially when patients cough and sneeze frequently, contributing to nosocomial transmission of infl uenza. As there is no reliable, safe marker that can be introduced into human lungs for experimental purposes, the laser smoke visualization method and the human patient simulator (HPS) model have been adopted as the method for studying exhaled air dispersion during application of various types of respiratory therapy in hospital medical wards, including the negative-pressure isolation room [ 10 -13 ] . Sections through the leakage jet plume were then revealed by a thin, green laser light sheet (532 nm wavelength, continuous-wave A laser beam located on the right side of the bed lateral to the human patient simulator illuminates the exhaled air particles leaking from the exhalation ports of the face mask in the coronal plane. abstract: Respiratory failure is a major complication of viral infections such as severe acute respiratory syndrome (SARS) [1], avian influenza H5N1 infection [2], and the 2009 pandemic influenza (H1N1) infection [3]. The course may progress rapidly to acute respiratory distress syndrome (ARDS) and multi-organ failure, requiring intensive care. Noninvasive ventilation (NIV) may play a supportive role in patients with severe viral pneumonia and early ARDS/acute lung injury. It can act as a bridge to invasive mechanical ventilation, although it is contraindicated in critically ill patients with hemodynamic instability and multi-organ dysfunction syndrome [4]. Transmission of some of these viral infections can convert from droplets to airborne during respiratory therapy. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121120/ doi: 10.1007/978-3-7091-1496-4_2 id: cord-276238-2hv46ftk author: Ing, Richard J. title: The role of helmet-delivered noninvasive pressure support ventilation in COVID-19 patients date: 2020-05-08 words: 3072 sentences: 213 pages: flesch: 49 cache: ./cache/cord-276238-2hv46ftk.txt txt: ./txt/cord-276238-2hv46ftk.txt summary: 5 The aim of this stand-alone editorial is to examine the role of helmet delivered continuous positive airway pressure (CPAP) noninvasive ventilation (NIV) as an adjunct to mechanical ventilation in patients requiring respiratory support in COVID-19. The recent Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 consensus statement agrees that; following admission for COVID-19, each patient may progress at a variable rate to either recovery, with minimal oxygen requirements and no ventilatory support, or a worsening of the disease process and the need for an escalation in NIV and mechanical ventilation. 11 The usual features of typical ARDS, recently termed the H-type, in COVID-19 patients are a progressive deteriorating lung compliance requiring increased inspired oxygen concentration(FiO 2 ), high positive end expiratory pressure (PEEP), prone ventilation, sedation with paralysis and inotropic support. abstract: nan url: https://doi.org/10.1053/j.jvca.2020.04.060 doi: 10.1053/j.jvca.2020.04.060 id: cord-016416-h3cjylcl author: Javouhey, Etienne title: Pathophysiology of Acute Respiratory Failure in Children with Bronchiolitis and Effect of CPAP date: 2013-05-29 words: 5576 sentences: 316 pages: flesch: 55 cache: ./cache/cord-016416-h3cjylcl.txt txt: ./txt/cord-016416-h3cjylcl.txt summary: Curiously, blood gas analyses have not been found to be good indicators of ventilatory support requirement except in the study of Campion et al., where a high level of CO 2 before CPAP was predictive of NIV failure defi ned as the need for invasive ventilation [ 8 ] . Liet and colleagues reported three cases of infants with severe bronchiolitis treated with this mode during invasive mechanical ventilation and showed that NAVA was able to improve synchrony, decrease the oxygen requirement, and decrease peak airway pressure from 28 ± 3 to 15 ± 5 cmH 2 O [ 33 ] . Moreover, as no study has been performed on NIV at two pressure levels in bronchiolitis, there is no evidence that NIV after CPAP or HFC failure can obviate the need for intubation and invasive ventilation. abstract: Acute bronchiolitis is the most common lower respiratory tract infection (LRTI) during the first year of life. Respiratory syncytial virus (RSV) infection is the most prevalent virus found in these children, accounting for 60–80 % of cases. The rate of hospitalization is less than 2 %. Up to 8 % of those hospitalized require ventilatory support [1, 2]. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120685/ doi: 10.1007/978-3-7091-1496-4_27 id: cord-014538-6a2pviol author: Kamilia, Chtara title: Proceedings of Réanimation 2017, the French Intensive Care Society International Congress date: 2017-01-10 words: 61068 sentences: 3463 pages: flesch: 49 cache: ./cache/cord-014538-6a2pviol.txt txt: ./txt/cord-014538-6a2pviol.txt summary: Other parameters that were significantly different between the patients who died and those who survived were an advanced age, an elevated IGS II score at hospital admission, an elevated SOFA score at study entry, a late healthcare-associated infection and several biological variables: a high C reactive protein, low albumin and prealbumin and a poor percent of monocytes expressing HLA-DR, all measured at day 7. Parameters collected were demographic features, comorbidities, regular treatment, dyspnea assessed by the MRC scale, initial clinical severity reflected by SAPS II and APACHE II scores, modalities and ICU admission deadlines, initial arterial blood gas analysis, management of patients in the ICU (ventilation modalities, prescription of antibiotics, use of vasoactive drugs) and their outcomes (incidence of nosocomial infections and their sites, length of stay and ICU mortality). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225389/ doi: 10.1186/s13613-016-0224-7 id: cord-327622-ezgufe24 author: Kaur, Ramandeep title: Practical strategies to reduce nosocomial transmission to healthcare professionals providing respiratory care to patients with COVID-19 date: 2020-09-23 words: 6333 sentences: 355 pages: flesch: 43 cache: ./cache/cord-327622-ezgufe24.txt txt: ./txt/cord-327622-ezgufe24.txt summary: • When removing the endotracheal tube, simultaneously turn off the ventilator • Avoid disconnecting ETT from the ventilator circuit before extubation to reduce spray of contaminated aerosols 9 Transport • Place a filter between the artificial airway and the transport ventilator circuit • Use HME that has filter function (HME-F) • Consider clamping the ETT before disconnection from ventilator circuit 10 Bronchoscopy assist* 2 in vivo [44, 45] • For spontaneously breathing patients, place a surgical mask on patient''s face (Fig. 7a, b) • Use NIV mask with examination port for patients on NIV (Fig. 7d) • Use swivel adapter to insert bronchoscope for intubated patient (Fig. 7c) Abbreviations: HFNC high-flow nasal cannula, IPPB intermittent positive pressure breathing, HME heat moisture exchanger, ETT endotracheal tube, NIV non-invasive ventilation *Based on CDC guidelines, these procedures should ideally be performed in airborne infection isolation rooms entrainment or nonrebreather mask [53] . abstract: Coronavirus disease (COVID-19) is an emerging viral infection that is rapidly spreading across the globe. SARS-CoV-2 belongs to the same coronavirus class that caused respiratory illnesses such as severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). During the SARS and MERS outbreaks, many frontline healthcare workers were infected when performing high-risk aerosol-generating medical procedures as well as when providing basic patient care. Similarly, COVID-19 disease has been reported to infect healthcare workers at a rate of ~ 3% of cases treated in the USA. In this review, we conducted an extensive literature search to develop practical strategies that can be implemented when providing respiratory treatments to COVID-19 patients, with the aim to help prevent nosocomial transmission to the frontline workers. url: https://doi.org/10.1186/s13054-020-03231-8 doi: 10.1186/s13054-020-03231-8 id: cord-016042-iyuca9lv author: Keymel, Stefanie title: Noninvasive Mechanical Ventilation Guidelines and Standard Protocols for Noninvasive Mechanical Ventilation in Patients with High-Risk Infections date: 2013-05-29 words: 1665 sentences: 97 pages: flesch: 44 cache: ./cache/cord-016042-iyuca9lv.txt txt: ./txt/cord-016042-iyuca9lv.txt summary: Noninvasive ventilation (NIV) is associated with lower rates of endotracheal intubation and decreased mortality in patients with acute respiratory failure. With endemic and high-risk infection, most of the critically ill patients develop acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS). A year later, the British Thoracic Society (BTS) published guidelines on the use of NIV in patients with acute respiratory failure (ARF). The Canadian Critical Care Trials group made no recommendations about the use of NIV in ARDS patients or those with severe community-acquired pneumonia (CAP) in 2011 [ 5 ] . • Current guidelines do not recommend NIV for the treatment of hypoxemic respiratory failure in endemic and pandemic infections (e.g., SARS or H1N1). International consensus conference in intensive care medicine: noninvasive positive pressure ventilation in acute respiratory failure Noninvasive positive pressure ventilation treatment for acute respiratory failure in SARS abstract: Noninvasive ventilation (NIV) is associated with lower rates of endotracheal intubation and decreased mortality in patients with acute respiratory failure. Therefore, NIV should be preferred to invasive ventilation whenever possible [1]. In clinical settings, most of the patients were treated by NIV because of pulmonary edema or exacerbated chronic obstructive lung disease (COPD) [2]. With endemic and high-risk infection, most of the critically ill patients develop acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS). Furthermore, NIV, an “aerosol-producing factor” might be regarded as a high-risk procedure for medical staff [3]. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120195/ doi: 10.1007/978-3-7091-1496-4_40 id: cord-352577-h3652seb author: Kopić, Jasminka title: Expanding the Use of Noninvasive Ventilation During an Epidemic date: 2014-08-27 words: 3340 sentences: 183 pages: flesch: 39 cache: ./cache/cord-352577-h3652seb.txt txt: ./txt/cord-352577-h3652seb.txt summary: 4 When appropriately indicated and promptly administered, NIV offers an alternative to tracheal intubation, sedation, risk of infection, and myriad complications associated with invasive ventilation, and it can promote rapid respiratory recovery, and reduce a patient''s dependence on critical care facilities. Rello et al described NIV use at ICU admission in 1 of 3 patients with H1N1 virus and respiratory failure, but 75% of them had an unfavorable clinical course and required tracheal intubation and invasive mechanical ventilation. In a position statement, the Australian Society for Infectious Diseases recommends "reserving negative-pressure ventilation rooms (if available) for intensive care patients, especially those receiving non-invasive ventilation." 31 The UK Department of Health, in "Guidance for infection control in critical care for pandemic influenza," approved the use of NIV under strict infection control measures. abstract: Noninvasive ventilation (NIV) is a proved and effective therapeutic option for some patients with respiratory failure. During an epidemic, NIV can free up respirators and other intensive care unit equipment for patients with respiratory insufficiency whose survival depends exclusively on invasive ventilation. Some guidelines have indicated that NIV is potentially hazardous and should not be recommended for use during epidemics, given the perceived potential risk of transmission from aerosolized pathogen dispersion to other patients or medical staff. Conversely, some reports of previous epidemics describe NIV as a very efficient and safe modality of respiratory support, if strict infection control measures are implemented. We discuss NIV use during epidemics and indicate the need for prospective randomized clinical studies on the efficacy of NIV in epidemic conditions to provide important information to the current body of literature. Meanwhile, the use of NIV under strict infection control guidelines should be incorporated into epidemic preparedness planning. (Disaster Med Public Health Preparedness. 2014;8:1-5) url: https://doi.org/10.1017/dmp.2014.71 doi: 10.1017/dmp.2014.71 id: cord-002078-38rmx65j author: Korkmaz Ekren, Pervin title: Can fiberoptic bronchoscopy be applied to critically ill patients treated with noninvasive ventilation for acute respiratory distress syndrome? Prospective observational study date: 2016-05-31 words: 3579 sentences: 253 pages: flesch: 45 cache: ./cache/cord-002078-38rmx65j.txt txt: ./txt/cord-002078-38rmx65j.txt summary: title: Can fiberoptic bronchoscopy be applied to critically ill patients treated with noninvasive ventilation for acute respiratory distress syndrome? The primary outcome of this prospective observational study was to evaluate the feasibility, safety and contribution in diagnosis and/or modification of the ongoing treatment of fiberoptic bronchoscopy (FOB) in patients with ARDS treated with NIV. METHODS: ARDS patients treated with NIV and who require FOB as the diagnostic or therapeutic procedure were included the study. Fiberoptic bronchoscopy (FOB) may be required in some patients with acute respiratory failure in intensive care units (ICU), mainly as diagnostic tool or to remove abundant secretions [7, 8] . Abbreviations APACHE II: Acute Physiology and Chronic Health Evaluation II; ARDS: acute respiratory distress syndrome; BAL: bronchoalveolar lavage; COPD: chronic obstructive pulmonary disease; EPAP: expiratory positive airway pressures; FOB: fiberoptic bronchoscopy; ICU: intensive care unit; IPAP: inspiratory positive airway pressure; NIV: noninvasive ventilation; PEEP: positive end expiratory pressure. abstract: BACKGROUND: Noninvasive ventilation (NIV) is a cornerstone for the treatment of acute respiratory failure of various etiologies. Using NIV is discussed in mild-to-moderate acute respiratory distress syndrome (ARDS) patients (PaO(2)/FiO(2) > 150). These patients often have comorbidities that increase the risk for bronchoscopy related complications. The primary outcome of this prospective observational study was to evaluate the feasibility, safety and contribution in diagnosis and/or modification of the ongoing treatment of fiberoptic bronchoscopy (FOB) in patients with ARDS treated with NIV. METHODS: ARDS patients treated with NIV and who require FOB as the diagnostic or therapeutic procedure were included the study. Intensive care ventilators or other dedicated NIV ventilators were used. NIV was applied via simple oro-nasal mask or full-face mask. Pressure support or inspiratory positive airway pressure (IPAP), external positive end expiratory pressure (PEEP) or expiratory positive airway pressure (EPAP) levels were titrated to achieve an expiratory tidal volume of 8 to 10 ml/kg according to ideal body weight, SpO(2) > 90 % and respiratory rate below 25/min. RESULTS: Twenty eight subjects (mean age 63.3 ± 15.9 years, 15 men, 13 women, PaO(2)/FiO(2) rate 145 ± 50.1 at admission) were included the study. Overall the procedure was well tolerated with only 5 (17.9 %) patients showing minor complications. There was no impairment in arterial blood gas and cardiopulmonary parameters after FOB. PaO(2)/FiO(2) rate increased from 132.2 ± 49.8 to 172.9 ± 63.2 (p = 0.001). No patient was intubated within 2 h after the bronchoscopy. 10.7, 32.1 and 39.3 % of the patients required invasive mechanical ventilation after 8 h, 24 h and 48 h, respectively. Bronchoscopy provided diagnosis in 27 (96.4 %) patients. Appropriate treatment was decided according to the results of the bronchoscopic sampling in 20 (71.4 %) patients. CONCLUSION: FOB under NIV could be considered as a feasible tool for diagnosis and guide for treatment of patients with ARDS treated via NIV in intensive care units. However, FOB-correlated life-treathening complications in severe hypoxemia should not be forgotten. Furthermore, further controlled studies involving a larger series of homogeneous ARDS patients undergoing FOB under NIV are needed to confirm these preliminary findings. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886426/ doi: 10.1186/s12890-016-0236-y id: cord-293170-ir2y6sfz author: Lal, Tusharindra title: COVID-19 patients: when and whom to ventilate? date: 2020-08-19 words: 686 sentences: 37 pages: flesch: 49 cache: ./cache/cord-293170-ir2y6sfz.txt txt: ./txt/cord-293170-ir2y6sfz.txt summary: As the cases of severe acute respiratory syndrome (SARS) increase rapidly, finding ICU beds, ventilators, intensivists, and critical care nurses remains a big challenge. A metaanalysis that included 1,084 patients from eight selected studies showed that high-flow nasal cannula (HFNC) treatment could reduce the rate of endotracheal intubation and ICU mortality [3] . A more recent review concluded that HFNC and NIV should be reserved for patients with mild acute respiratory distress syndrome until further data are available [4]. With medical facilities severely stretched out, especially in resource-limited regions like India and other developing nations with large population clusters, selective use of HFNC or NIV may reduce the need for ventilated ICU beds while achieving desired clinical results. Large RCTs or well-designed observational studies are needed to define stratification of COVID-19 patients for the best choice of initial respiratory support keeping in mind the resources available and the judicious and timely use of invasive ventilation. abstract: nan url: https://doi.org/10.4266/acc.2020.00451 doi: 10.4266/acc.2020.00451 id: cord-017282-rahtmu3h author: Marvisi, Maurizio title: Pneumonia date: 2019-08-06 words: 2532 sentences: 131 pages: flesch: 40 cache: ./cache/cord-017282-rahtmu3h.txt txt: ./txt/cord-017282-rahtmu3h.txt summary: All patients with CAP should receive oxygen treatment as needed with the aim of maintaining an arterial oxygen saturation (SpO 2 ) of 92% corresponding to a partial pressure of oxygen in the blood of about 60 mmHg. Lower values are accepted in cases of underlying severe pulmonary disease with a risk of carbon dioxide retention. While the clinical practice guidelines on evidence-based application of NIV for community-acquired pneumonia did not provide a recommendation for its use, the Infectious Disease Society of America/American Thoracic Society guidelines on management of CAP did suggest a cautious trial of NIV [2, 12] . Most studies on NIV and treatment of acute hypoxemic respiratory failure, including CAP, have been carried out in the critical care setting and have reported controversial results with varying failure rates for NIV use. Effect of noninvasive ventilation vs oxygen therapy on mortality among immunocompromised patients with acute respiratory failure: a randomized clinical trial Effectiveness of high-flow nasal cannula oxygen therapy for acute respiratory failure with hypercapnia abstract: Pneumonia is a common cause of hospital admission and community-acquired pneumonia (CAP) is a growing health problem in developed country and worldwide. Elderly patients suffer from more severe disease, require intensive care unit (ICU) admission, and exhibit higher mortality compared with their younger counterparts. The immunological changes that occur with age called “immunosenescence” (decreased efficiency of the adaptive and innate immune systems) are known to be responsible for the increased susceptibility of elderly persons to infectious diseases and for their limited response to vaccines [1]. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121799/ doi: 10.1007/978-3-030-26664-6_12 id: cord-103020-ckuma42j author: McDowell, G. title: Two-way remote monitoring allows effective and realistic provision of home-NIV to COPD patients with persistent hypercapnia. date: 2020-11-12 words: 5817 sentences: 316 pages: flesch: 48 cache: ./cache/cord-103020-ckuma42j.txt txt: ./txt/cord-103020-ckuma42j.txt summary: Background Outcomes for chronic obstructive pulmonary disease (COPD) patients with persistent hypercapnic respiratory failure are improved by long-term home non-invasive ventilation (NIV). The primary outcome of this study was time to readmission or death at 12 months in patients receiving home-NIV versus a retrospectively identified control cohort of 27 patients with hypercapnic COPD who had not been referred for home-NIV. The present study retrospectively analysed all patients who were commenced on therapy over the first 12 months of this service, with aim of determining whether outcomes similar to RCTs were achieved in a real-world cohort of hypercapnic COPD patients with typical comorbidities (which would have excluded many from NIV RCTs) who are managed with remote-monitored home NIV. Changes in healthcare usage (number of hospital admissions, OBDs, and respiratory nurse home visits) and capillary blood gas PCO 2 and bicarbonate between NIV users, NIV non-users and the control cohort were analysed using Wilcoxon signed-rank test. abstract: Background Outcomes for chronic obstructive pulmonary disease (COPD) patients with persistent hypercapnic respiratory failure are improved by long-term home non-invasive ventilation (NIV). Provision of home-NIV presents clinical and service challenges. The aim of this study was to assess outcomes of home-NIV in hypercapnic COPD patients managed remotely. Methods Retrospective analysis of a dataset of 46 COPD patients with persistent hypercapnic respiratory failure who commenced home-NIV managed by two-way remote monitoring (Lumis, AirView, ResMed) between February 2017 and January 2018. The primary outcome of this study was time to readmission or death at 12 months in patients receiving home-NIV versus a retrospectively identified control cohort of 27 patients with hypercapnic COPD who had not been referred for home-NIV. Results The median time to readmission or death was significantly prolonged in patients who commenced home-NIV (median 160 days, 95% CI 69.38-250.63) versus the control cohort (66 days, 95% CI 21.9-110.1; p<0.01). Average time to hospital readmission was 221 days (95% CI, 47.77-394.23) and 70 days (95% CI, 55.31-84.69; p<0.05), respectively. Median decrease in bicarbonate level of 4.9mmol/L (p<0.0151) and daytime PCO2 2.2kPa (p<0.032) demonstrate efficacy of home-NIV. A median reduction of 14 occupied bed days per annum versus previous year prior to NIV was observed per patient who continued home-NIV throughout the study period (N=32). Conclusion These findings confirm the benefits of home-NIV in clinical practice and support the use of two-way remote monitoring as a feasible solution to managing the delivery of home-NIV for COPD patients with persistent hypercapnia. url: http://medrxiv.org/cgi/content/short/2020.11.08.20227892v1?rss=1 doi: 10.1101/2020.11.08.20227892 id: cord-336690-ajmuaw10 author: McEnery, Tom title: COVID-19: Respiratory support outside the intensive care unit date: 2020-04-09 words: 928 sentences: 53 pages: flesch: 50 cache: ./cache/cord-336690-ajmuaw10.txt txt: ./txt/cord-336690-ajmuaw10.txt summary: The optimal mode of respiratory support for individuals with severe coronavirus disease 2019 (COVID-19) before invasive mechanical ventilation (IMV) is currently a subject of much debate. Recently published guidelines 1 and a Comment 2 differ substantially to other guidelines in this regard, with some advocating high flow nasal cannulae (HFNC) over non-invasive ventilation (NIV), 1,2 or vice versa (NHS guidance). In acute respiratory distress syndrome (ARDS), early intubation was associated with survival benefit when PaO 2 /FiO 2 ratio was <150 when compared with NIV. Conversely, data from only one study 6 on the severe acute respiratory syndrome (SARS) outbreak suggest that NIV can successfully avoid intubation. Non-invasive ventilation of patients with acute respiratory distress syndrome. Effectiveness of non-invasive positive pressure ventilation in the treatment of acute respiratory failure in severe acute respiratory syndrome Inspiratory work with and without continuous positive airway pressure in patients with acute respiratory failure abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32278367/ doi: 10.1016/s2213-2600(20)30176-4 id: cord-268049-7xqln70d author: Montrief, Tim title: COVID-19 respiratory support in the emergency department setting date: 2020-08-08 words: 5197 sentences: 337 pages: flesch: 45 cache: ./cache/cord-268049-7xqln70d.txt txt: ./txt/cord-268049-7xqln70d.txt summary: DISCUSSION: Patients presenting with SARS-CoV-2 infection are at high risk for acute respiratory failure requiring airway management. [29] [30] [31] [32] Based on currently available evidence, the WHO states that "HFNC and NIV systems with good interface fitting do not create widespread dispersion of exhaled air and therefore should be associated with [a] low risk of airborne transmission." 15 The risk of respiratory pathogen transmission when using HFNC is subject to a variety of factors, including the duration of support, maximal flow rate, patient sneezing or coughing, cannula fit, and patient cooperation. 35 Many guidelines, including those by Australian and New Zealand Intensive Care Society (ANZICS), the WHO, and the Surviving Sepsis Campaign recommend the use of HFNC in COVID-19 patients presenting with acute hypoxemic respiratory failure unresponsive to conventional oxygen therapy. 20 Notably, the SCCM guidelines on the management of critically ill patients with COVID-19 recommend "a trial of NIV with close monitoring and shortinterval assessment for worsening of respiratory failure" if HFNC is not available and there is no urgent indication for intubation. abstract: INTRODUCTION: Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), which causes the coronavirus disease 2019 (COVID-19), may result in severe complications, multiorgan dysfunction, acute respiratory failure, and death. SARS-CoV-2 is highly contagious and places healthcare workers at significant risk, especially during aerosol-generating procedures, including airway management. OBJECTIVE: This narrative review outlines the underlying respiratory pathophysiology of patients with COVID-19 and discusses approaches to airway management in the emergency department (ED) based on current literature. DISCUSSION: Patients presenting with SARS-CoV-2 infection are at high risk for acute respiratory failure requiring airway management. Among hospitalized patients, 10–20% require intensive care unit admission, and 3–10% require intubation and mechanical ventilation. While providing respiratory support for these patients, proper infection control measures, including adherence to personal protective equipment policies, are necessary to prevent nosocomial transmission to healthcare workers. A structured approach to respiratory failure in these patients includes the use of exogenous oxygen via nasal cannula or non-rebreather, as well as titrated high-flow nasal cannula and non-invasive ventilation. This review offers several guiding principles and resources designed to be adapted in conjunction with local workplace policies for patients requiring endotracheal intubation. CONCLUSIONS: While the fundamental principles of acute respiratory failure management are similar between COVID-19 and non-COVID-19 patients, there are some notable differences, including a focus on provider safety. This review provides an approach to airway management and respiratory support in the patient with COVID-19. url: https://doi.org/10.1016/j.ajem.2020.08.001 doi: 10.1016/j.ajem.2020.08.001 id: cord-034185-e0am7pa6 author: Piccioni, Federico title: Recommendations from the Italian intersociety consensus on Perioperative Anesthesa Care in Thoracic surgery (PACTS) part 2: intraoperative and postoperative care date: 2020-10-23 words: 18220 sentences: 941 pages: flesch: 37 cache: ./cache/cord-034185-e0am7pa6.txt txt: ./txt/cord-034185-e0am7pa6.txt summary: We do not recommend the routine use of either continuous positive airway pressure (CPAP) or non invasive ventilation (NIV) to prevent postoperative pulmonary complications, prolonged length of stay, and mortality (both in ICU and in hospital) in patients undergoing major thoracic surgery. Level of evidence: Fair Strength of recommendation: C A meta-analysis of 45 studies including almost 5800 patients showed that a single perioperative dose of intravenous dexamethasone resulted in significant reductions in pain scores and opioid use, and was associated with shorter stays in the post-anesthesia recovery room, compared with placebo or antiemetic treatment (Waldron et al. Level of evidence: Fair Strength of recommendation: A Multiple clinical trials have shown that, in patients undergoing open thoracotomy or other major surgical procedures, thoracic epidural analgesia (TEA) is superior to intravenous opioid administration in terms of postoperative pain relief, length of hospital stay, and incidence of postoperative complications (Hazelrigg et al. abstract: INTRODUCTION: Anesthetic care in patients undergoing thoracic surgery presents specific challenges that require a multidisciplinary approach to management. There remains a need for standardized, evidence-based, continuously updated guidelines for perioperative care in these patients. METHODS: A multidisciplinary expert group, the Perioperative Anesthesia in Thoracic Surgery (PACTS) group, was established to develop recommendations for anesthesia practice in patients undergoing elective lung resection for lung cancer. The project addressed three key areas: preoperative patient assessment and preparation, intraoperative management (surgical and anesthesiologic care), and postoperative care and discharge. A series of clinical questions was developed, and literature searches were performed to inform discussions around these areas, leading to the development of 69 recommendations. The quality of evidence and strength of recommendations were graded using the United States Preventive Services Task Force criteria. RESULTS: Recommendations for intraoperative care focus on airway management, and monitoring of vital signs, hemodynamics, blood gases, neuromuscular blockade, and depth of anesthesia. Recommendations for postoperative care focus on the provision of multimodal analgesia, intensive care unit (ICU) care, and specific measures such as chest drainage, mobilization, noninvasive ventilation, and atrial fibrillation prophylaxis. CONCLUSIONS: These recommendations should help clinicians to improve intraoperative and postoperative management, and thereby achieve better postoperative outcomes in thoracic surgery patients. Further refinement of the recommendations can be anticipated as the literature continues to evolve. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582032/ doi: 10.1186/s13741-020-00159-z id: cord-354330-pud2rqxk author: Pirzada, Abdul Rouf title: Management of Aerosol during Noninvasive Ventilation for Patients with Sleep-Disordered Breathing: Important Messages during the COVID-19 Pandemic date: 2020-06-17 words: 3206 sentences: 148 pages: flesch: 46 cache: ./cache/cord-354330-pud2rqxk.txt txt: ./txt/cord-354330-pud2rqxk.txt summary: The procedures that are believed to have a potential to generate aerosols and droplets as a source of respiratory pathogens include positive pressure ventilation (bilevel positive airway pressure (BPAP) and continuous positive airway pressure (CPAP)), endotracheal intubation, airway suction, high-frequency oscillatory ventilation, tracheostomy, chest physiotherapy, nebulizer treatment, sputum induction, and bronchoscopy [5] [6] [7] . In the hospital, the procedures that are believed to or have a potential to generate aerosols and droplets as a source of respiratory pathogens include positive pressure ventilation (BiPAP and CPAP), endotracheal intubation, airway suction, high-frequency oscillatory ventilation, tracheostomy, chest physiotherapy, nebulizer treatment, sputum induction, and bronchoscopy [5, 8] . NIV in hospital, in a setting of suspected or confirmed case of COVID-19, warrants infectious disease protocol of isolation in negative pressure room preferably with an anteroom and attached washroom (well ventilated) and personal protective equipment for attending staff; however, it is not possible in high volume patient inflow. abstract: With the advent of COVID-19 infection and its rapid spread, preventive strategies are being developed worldwide, besides following the universal infection control guidelines. Prevention of spread through aerosol generation is one of the essential strategies in this regard, particularly for patients with sleep-disordered breathing at home and during hospital admission. Aerosols are produced, at home and in health care facilities, by natural processes and aerosol-generating procedures. To address this impinging problem, aerosol-generating procedures, like non-invasive ventilation (NIV), are to be handled meticulously, which might warrant isolation and sometimes device/interface modifications. url: https://doi.org/10.1007/s41782-020-00092-7 doi: 10.1007/s41782-020-00092-7 id: cord-015548-zjrkfe9b author: Popat, Bhavesh title: Invasive and non-invasive mechanical ventilation date: 2012-05-18 words: 3044 sentences: 149 pages: flesch: 32 cache: ./cache/cord-015548-zjrkfe9b.txt txt: ./txt/cord-015548-zjrkfe9b.txt summary: Early use of non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary disease on general respiratory wards: a multicentre randomised controlled trial Clinical practice guideline for the use of noninvasive positive pressure ventilation in COPD patients with acute respiratory failure Non-invasive positive pressure ventilation to treat respiratory failure resulting from exacerbations of chronic obstructive pulmonary disease: cochrane systematic review and meta-analysis Non-invasive positive pressure ventilation for treatment of respiratory failure due to exacerbations of chronic obstructive pulmonary disease. Randomised controlled comparison of continuous positive airways pressure, bilevel non-invasive ventilation, and standard treatment in emergency department patients with acute cardiogenic pulmonary oedema Non-invasive pressure support ventilation versus conventional oxygen therapy in acute cardiogenic pulmonary oedema: a randomised trial The evidence for noninvasive positive-pressure ventilation in the care of patients in acute respiratory failure: a systematic review of the literature Non-invasive positive pressure ventilation for treatment of respiratory failure due to severe acute exacerbations of asthma abstract: Early recognition of patients who might potentially require ventilatory support is a key goal of critical care outreach programs and an important skill for all hospital medical staff. Decisions about the initiation and timing of invasive ventilation can be difficult and early discussion with critical care colleagues is essential. Appropriateness of invasive ventilatory support may also be an issue requiring advanced discussion with patients and their families. In the past 10–15 years, the role of non-invasive ventilation (NIV) has expanded, not least in an attempt to minimize the complications inherent with invasive ventilation. As such, NIV is now considered first-line therapy in some conditions (chronic obstructive pulmonary disease, pulmonary oedema, mild-to-moderate hypoxaemic respiratory failure in immunocompromised patients), and a ‘trial of NIV’ is often considered in respiratory failure resulting from an increasingly wide range of causes. When using NIV, the importance of the environment (setting, monitoring and experience of staff) and forward planning cannot be overemphasized. When used for other than the standard indications, NIV should be employed in a high-dependency/intensive care setting only in patients for whom invasive ventilation would be considered. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108446/ doi: 10.1016/j.mpmed.2012.03.010 id: cord-312864-km07zhn1 author: Potalivo, A. title: Sixty-day mortality among 520 Italian hospitalized COVID-19 patients according to the adopted ventilatory strategy in the context of an integrated multidisciplinary clinical organization: a population-based cohort study date: 2020-08-15 words: 5381 sentences: 255 pages: flesch: 50 cache: ./cache/cord-312864-km07zhn1.txt txt: ./txt/cord-312864-km07zhn1.txt summary: title: Sixty-day mortality among 520 Italian hospitalized COVID-19 patients according to the adopted ventilatory strategy in the context of an integrated multidisciplinary clinical organization: a population-based cohort study 4, 8, 9, 11 Thus, the number of hospitalized COVID-19 patients treated with oxygen supplementation and NIV has been markedly underreported leading to inaccurate information regarding the overall use of the different respiratory supports and outcomes. Using clinical and demographics information routinely collected in a unique database including all residents in the entire province, we performed the present population-based cohort study with the following aims: 1) to describe the characteristics of hospitalized COVID-19 patients, 2) to examine patient outcomes overall and stratified by the adopted respiratory support, 3) to describe the organization of local healthcare system. It should be noted that in our study we documented for patients treated with NIV and/or IMV -despite a similar P/F ratio (median 98.0; IQR 84.0-124.5) and a higher SOFA score (median 8; IQR 6-10)-a considerably lower 60-day mortality rate, overall and in individual groups. abstract: Background: Among COVID-19 patients, the decision of which ventilation strategy to adopt is crucial and not guided by existing outcome evidence. We described the clinical characteristics and outcomes of hospitalized COVID-19 patients according to the adopted respiratory strategy. Methods: Population-based cohort study including all COVID-19 patients (26/02/2020-18/04/2020) within Rimini Italian province. Hospitalized patients were classified according to the maximum level of respiratory support: oxygen supplementation (group Oxygen), NIV (group NIV-only), IMV (group IMV-only), and IMV after a NIV trial (group IMV-after-NIV). Sixty-day mortality risk was estimated with a Cox proportional hazard analysis adjusted by age, sex, and administration of steroids, canakinumab, and tocilizumab. Findings: We identified 1,424 symptomatic patients: 520 (36.5%) were hospitalized, the remaining 904 (63.5%) were treated at home with no 60-days death. According to the respiratory support, 408 (78.5%) were assigned to Oxygen, 46 (8.8%) to NIV-only, 25 (4.8%) to IMV-after-NIV, and 41 (7.9%) to IMV-only groups. There was no significant difference in the P/F at IMV inception among IMV-after-NIV and IMV-only groups (p=0.9). Overall 60-day mortality was 24.2% (Oxygen: 23.0%; NIV-only: 19.6%; IMV-after-NIV: 32.0%; IMV-only: 36.6%; p = 0.165). Compared with Oxygen group, the 60-day mortality risk significantly increased for IMV-after-NIV (HR 2.776; p=0.024) and IMV-only group (HR 2.966; p=0.001). Conclusions: This study provides a population-based figure of the impact of the COVID-19 epidemic. A similar 60-days mortality risk was found for patients undergoing immediate IMV and those intubated after a NIV trial. Many patients had a favorable outcome after prolonged IMV. url: http://medrxiv.org/cgi/content/short/2020.08.13.20174615v1?rss=1 doi: 10.1101/2020.08.13.20174615 id: cord-000705-w52dc97h author: Ríos, Fernando G title: Lung Function and Organ Dysfunctions in 178 Patients Requiring Mechanical Ventilation During The 2009 Influenza A (H1N1) Pandemic date: 2011-08-17 words: 4859 sentences: 301 pages: flesch: 48 cache: ./cache/cord-000705-w52dc97h.txt txt: ./txt/cord-000705-w52dc97h.txt summary: METHOD: This was a multicenter, prospective inception cohort study including adult patients with acute respiratory failure requiring mechanical ventilation (MV) admitted to 20 ICUs in Argentina between June and September of 2009 during the influenza A (H1N1) pandemic. Although a mild form of the disease was prevalent, it soon became evident that the 2009 influenza A (H1N1) virus could also provoke severe, acute respiratory failure requiring admission to the intensive care unit (ICU) for mechanical ventilation [16] , which was reflected in the severe pathological injury found at autopsy [17] . This was a multicenter, inception cohort study that included patients aged > 15 years admitted to the ICU with a previous history of influenza-like illness, evolving to acute respiratory failure that required mechanical ventilation during the 2009 winter in the Southern Hemisphere. We report on a large, prospective cohort of 2009 influenza A (H1N1) patients that were mechanically ventilated for acute respiratory failure due to diffuse pneumonitis during the pandemic in Argentina. abstract: INTRODUCTION: Most cases of the 2009 influenza A (H1N1) infection are self-limited, but occasionally the disease evolves to a severe condition needing hospitalization. Here we describe the evolution of the respiratory compromise, ventilatory management and laboratory variables of patients with diffuse viral pneumonitis caused by pandemic 2009 influenza A (H1N1) admitted to the ICU. METHOD: This was a multicenter, prospective inception cohort study including adult patients with acute respiratory failure requiring mechanical ventilation (MV) admitted to 20 ICUs in Argentina between June and September of 2009 during the influenza A (H1N1) pandemic. In a standard case-report form, we collected epidemiological characteristics, results of real-time reverse-transcriptase--polymerase-chain-reaction viral diagnostic tests, oxygenation variables, acid-base status, respiratory mechanics, ventilation management and laboratory tests. Variables were recorded on ICU admission and at days 3, 7 and 10. RESULTS: During the study period 178 patients with diffuse viral pneumonitis requiring MV were admitted. They were 44 ± 15 years of age, with Acute Physiology And Chronic Health Evaluation II (APACHE II) scores of 18 ± 7, and most frequent comorbidities were obesity (26%), previous respiratory disease (24%) and immunosuppression (16%). Non-invasive ventilation (NIV) was applied in 49 (28%) patients on admission, but 94% were later intubated. Acute respiratory distress syndrome (ARDS) was present throughout the entire ICU stay in the whole group (mean PaO(2)/FIO(2 )170 ± 25). Tidal-volumes used were 7.8 to 8.1 ml/kg (ideal body weight), plateau pressures always remained < 30 cmH(2)O, without differences between survivors and non-survivors; and mean positive end-expiratory pressure (PEEP) levels used were between 8 to 12 cm H(2)O. Rescue therapies, like recruitment maneuvers (8 to 35%), prone positioning (12 to 24%) and tracheal gas insufflation (3%) were frequently applied. At all time points, pH, platelet count, lactate dehydrogenase assay (LDH) and Sequential Organ Failure Assessment (SOFA) differed significantly between survivors and non-survivors. Lack of recovery of platelet count and persistence of leukocytosis were characteristic of non-survivors. Mortality was high (46%); and length of MV was 10 (6 to 17) days. CONCLUSIONS: These patients had severe, hypoxemic respiratory failure compatible with ARDS that persisted over time, frequently requiring rescue therapies to support oxygenation. NIV use is not warranted, given its high failure rate. Death and evolution to prolonged mechanical ventilation were common outcomes. Persistence of thrombocytopenia, acidosis and leukocytosis, and high LDH levels found in non-survivors during the course of the disease might be novel prognostic findings. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387643/ doi: 10.1186/cc10369 id: cord-011269-j2rogzm7 author: Stefan, Mihaela S. title: Protocol for two-arm pragmatic cluster randomized hybrid implementation-effectiveness trial comparing two education strategies for improving the uptake of noninvasive ventilation in patients with severe COPD exacerbation date: 2020-05-06 words: 7383 sentences: 335 pages: flesch: 39 cache: ./cache/cord-011269-j2rogzm7.txt txt: ./txt/cord-011269-j2rogzm7.txt summary: title: Protocol for two-arm pragmatic cluster randomized hybrid implementation-effectiveness trial comparing two education strategies for improving the uptake of noninvasive ventilation in patients with severe COPD exacerbation Through a series of mixed-methods studies, we have found that successful implementation of NIV requires physicians, respiratory therapists (RTs), and nurses to communicate and collaborate effectively, suggesting that efforts to increase the use of NIV in COPD need to account for the complex and interdisciplinary nature of NIV delivery and the need for team coordination. The overall objective of this study is to conduct a pragmatic, parallel, 2-arm randomized cluster trial to compare the effectiveness of two implementation strategies: on-line education (OLE) and interprofessional education (IPE) on the uptake of NIV. Hospitals that demonstrate interest in participating in the study will be asked to commit to form a COPD-NIV team composed of one physician, one RT, and one nurse that will be in close contact with the investigators and are responsible for delivering the educational intervention in their institution. abstract: BACKGROUND: COPD is the fourth leading cause of death in the US, and COPD exacerbations result in approximately 700,000 hospitalizations annually. Patients with acute respiratory failure due to severe COPD exacerbation are treated with invasive (IMV) or noninvasive mechanical ventilation (NIV). Although IMV reverses hypercapnia/hypoxia, it causes significant morbidity and mortality. There is strong evidence that patients treated with NIV have better outcomes, and NIV is recommended as first line therapy in these patients. Yet, several studies have demonstrated substantial variation in the use of NIV across hospitals, leading to preventable morbidity and mortality. Through a series of mixed-methods studies, we have found that successful implementation of NIV requires physicians, respiratory therapists (RTs), and nurses to communicate and collaborate effectively, suggesting that efforts to increase the use of NIV in COPD need to account for the complex and interdisciplinary nature of NIV delivery and the need for team coordination. Therefore, we propose to compare two educational strategies: online education (OLE) and interprofessional education (IPE) which targets complex team-based care in NIV delivery. METHODS AND DESIGN: Twenty hospitals with low baseline rates of NIV use will be randomized to either the OLE or IPE study arm. The primary outcome of the trial is change in the hospital rate of NIV use among patients with COPD requiring ventilatory support. In aim 1, we will compare the uptake change over time of NIV use among patients with COPD in hospitals enrolled in the two arms. In aim 2, we will explore mediators’ role (respiratory therapist autonomy and team functionality) on the relationship between the implementation strategies and implementation effectiveness. Finally, in aim 3, through interviews with providers, we will assess acceptability and feasibility of the educational training. DISCUSSIONS: This study will be among the first to carefully test the impact of IPE in the inpatient setting. This work promises to change practice by offering approaches to facilitate greater uptake of NIV and may generalize to other interventions directed to seriously-ill patients. TRIAL REGISTRATION: Name of registry: ClinicalTrials.gov Trial registration number: NCT04206735 Date of Registration: December 20, 2019 url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223919/ doi: 10.1186/s43058-020-00028-2 id: cord-030131-klhg7x8z author: Tan, Dingyu title: High-flow nasal cannula oxygen therapy versus non-invasive ventilation for chronic obstructive pulmonary disease patients after extubation: a multicenter, randomized controlled trial date: 2020-08-06 words: 4583 sentences: 200 pages: flesch: 45 cache: ./cache/cord-030131-klhg7x8z.txt txt: ./txt/cord-030131-klhg7x8z.txt summary: title: High-flow nasal cannula oxygen therapy versus non-invasive ventilation for chronic obstructive pulmonary disease patients after extubation: a multicenter, randomized controlled trial This study was conducted to test if HFNC is non-inferior to non-invasive ventilation (NIV) in preventing post-extubation treatment failure in COPD patients previously intubated for hypercapnic respiratory failure. METHODS: COPD patients with hypercapnic respiratory failure who were already receiving invasive ventilation were randomized to HFNC or NIV at extubation at two large tertiary academic teaching hospitals. CONCLUSION: Among COPD patients with severe hypercapnic respiratory failure who received invasive ventilation, the use of HFNC after extubation did not result in increased rates of treatment failure compared with NIV. Among COPD patients with severe hypercapnic respiratory failure who received invasive ventilation, the use of HFNC as compared with NIV after extubation did not result in increased rates of treatment failure, while HFNC had better tolerance and comfort. abstract: BACKGROUND: High-flow nasal cannula (HFNC) oxygen therapy is being increasingly used to prevent post-extubation hypoxemic respiratory failure and reintubation. However, evidence to support the use of HFNC in chronic obstructive pulmonary disease (COPD) patients with hypercapnic respiratory failure after extubation is limited. This study was conducted to test if HFNC is non-inferior to non-invasive ventilation (NIV) in preventing post-extubation treatment failure in COPD patients previously intubated for hypercapnic respiratory failure. METHODS: COPD patients with hypercapnic respiratory failure who were already receiving invasive ventilation were randomized to HFNC or NIV at extubation at two large tertiary academic teaching hospitals. The primary endpoint was treatment failure, defined as either resumption of invasive ventilation or switching to the other study treatment modality (NIV for patients in the NFNC group or vice versa). RESULTS: Ninety-six patients were randomly assigned to the HFNC group or NIV group. After secondary exclusion, 44 patients in the HFNC group and 42 patients in the NIV group were included in the analysis. The treatment failure rate in the HFNC group was 22.7% and 28.6% in the NIV group—risk difference of − 5.8% (95% CI, − 23.8–12.4%, p = 0.535), which was significantly lower than the non-inferior margin of 9%. Analysis of the causes of treatment failure showed that treatment intolerance in the HFNC group was significantly lower than that in the NIV group, with a risk difference of − 50.0% (95% CI, − 74.6 to − 12.9%, p = 0.015). One hour after extubation, the mean respiratory rates of both groups were faster than their baseline levels before extubation (p < 0.050). Twenty-four hours after extubation, the respiratory rate of the HFNC group had returned to baseline, but the NIV group was still higher than the baseline. Forty-eight hours after extubation, the respiratory rates of both groups were not significantly different from the baseline. The average number of daily airway care interventions in the NIV group was 7 (5–9.3), which was significantly higher than 6 (4–7) times in the HFNC group (p = 0.006). The comfort score and incidence of nasal and facial skin breakdown of the HFNC group was also significantly better than that of the NIV group [7 (6–8) vs 5 (4–7), P < 0.001] and [0 vs 9.6%, p = 0.027], respectively. CONCLUSION: Among COPD patients with severe hypercapnic respiratory failure who received invasive ventilation, the use of HFNC after extubation did not result in increased rates of treatment failure compared with NIV. HFNC also had better tolerance and comfort than NIV. TRIAL REGISTRATION: chictr.org (ChiCTR1800018530). Registered on 22 September 2018, http://www.chictr.org.cn/usercenter.aspx url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407427/ doi: 10.1186/s13054-020-03214-9 id: cord-016844-lq2bgu7a author: Teksam, Ozlem title: Noninvasive Mechanical Ventilation in Patients with High-Risk Infections and Mass Casualties in Acute Respiratory Failure: Pediatric Perspective date: 2013-05-29 words: 3932 sentences: 206 pages: flesch: 45 cache: ./cache/cord-016844-lq2bgu7a.txt txt: ./txt/cord-016844-lq2bgu7a.txt summary: title: Noninvasive Mechanical Ventilation in Patients with High-Risk Infections and Mass Casualties in Acute Respiratory Failure: Pediatric Perspective Invasive mechanical ventilation (IMV) is a critical intervention in many cases of acute respiratory failure (ARF), but there are absolute risks associated with endotracheal intubation (ETI). Additionally, the World Health Organization''s interim guidelines on the prevention and control of acute respiratory diseases associated with health care have included NIV among the aerosol-generating procedures in which there is possibly an increased risk of respiratory pathogen transmission [ 11 ] . Nonetheless, after the most important two viral pandemics during the last decade, especially the last one with infl uenza A(H1N1), most of the societies including above-mentioned and the European Respiratory Society, European Society of Intensive Care Medicine, and The American Association for Respiratory Care have recommended that NIV not be used to treat ARF due to H1N1, particularly in severely ill patients. abstract: Respiratory problems are common symptoms in children and common reason for visits to the pediatric emergency department (PED) and admission to the pediatric intensive care unit (PICU). Although the great majority of cases are benign and self-limited, requiring no intervention, some patients need respiratory support. Invasive mechanical ventilation (IMV) is a critical intervention in many cases of acute respiratory failure (ARF), but there are absolute risks associated with endotracheal intubation (ETI). On the other hand, noninvasive ventilation (NIV) is an extremely valuable alternative to IMV. A major reason for the increasing use of NIV has been the desire to avoid the complications of IMV. It is generally much safer than IMV and has been shown to decrease resource utilization. Its use also avoids the complications and side effects associated with ETI, including upper airway trauma, laryngeal swelling, postextubation vocal cord dysfunction, nosocomial infections, and ventilator-associated pneumonia. There are a number of advantages of NIV including leaving the upper airway intact, preserving the natural defense mechanisms of the upper airways, decreasing the need for sedation, maintaining the ability to talk while undergoing NIV, and reducing the length of hospitalization and its associated costs [1–3]. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121261/ doi: 10.1007/978-3-7091-1496-4_29 id: cord-260220-f1tpkw1o author: Timenetsky, Karina T title: High success and low mortality rates with non-invasive ventilation in influenza A H1N1 patients in a tertiary hospital date: 2011-09-28 words: 3463 sentences: 189 pages: flesch: 54 cache: ./cache/cord-260220-f1tpkw1o.txt txt: ./txt/cord-260220-f1tpkw1o.txt summary: In this study we describe the respiratory profile, the mortality rate, and the benefit of using NIV in patients with confirmed diagnosis of influenza AH1N1 who were admitted in the ICU during the year 2009. To confirm the cases of swine-origin influenza A H1N1 virus by real-time RT-PCR (RT-RTPCR), nasopharyngeal-swab samples were collected at hospital admission and respiratory secretions obtained from intubated patients. Noninvasive mechanical ventilation was instituted in the confirmed influenza A H1N1 when there were signs of acute respiratory failure at hospital admission or during ICU stay. Patients that were admitted with signs of acute respiratory failure as described above, with extreme levels of hypoxemia (PaO2 lower than 60 mmHg with a high oxygen concentration delivered by a mask with a non re-breathing system -100%), low level of consciousness, or refuse to use NIV were promptly intubated at ICU admission. abstract: BACKGROUND: In 2009, an outbreak of respiratory illness caused by influenza A H1N1 virus occurred worldwide. Some patients required Intensive Care Unit (ICU) admission. The use of non-invasive ventilation (NIV) in these patients is controversial, as the aerosol dispersion may contaminate the environment and health-care co-workers. METHODS: Describe the respiratory profile, the mortality rate, and the benefit of using NIV in patients with confirmed diagnosis of influenza AH1N1 who were admitted in the ICU during the year 2009. RESULTS: A total of 1, 401 cases of influenza A H1N1 were confirmed in our hospital by real-time RT-PCR in 2009, and 20 patients were admitted to the ICU. The patients' ages ranged from 18 to 74 years (median of 42). Acute Respiratory Failure (ARF) was present in 70% of patients. The median Acute Physiology and Chronic Health Evaluation II score was 7 (range 7 to 25). Of the 14 patients who developed ARF, 85.7% needed NIV and 14% needed invasive MV at admission. Our success rate (41.6%) with NIV was higher than that described by others. The hospital mortality rate was 2.1%. When influenza A H1N1 arrived in Brazil, the disease was already on endemic alert in other countries. The population was already aware of the symptoms and the health-care system of the treatment. This allowed patients to be properly and promptly treated for influenza A H1N1, while health-care workers took protective measures to avoid contamination. CONCLUSION: In our study we found a high success and low mortality rates with non-invasive ventilation in patients with influenza A H1N1. url: https://doi.org/10.1186/1756-0500-4-375 doi: 10.1186/1756-0500-4-375 id: cord-017240-2vqehqfh author: Trindade e Silva, Luis Paulo title: Noninvasive Mechanical Ventilation for Hypoxemic Respiratory Failure-Related Infectious Diseases date: 2013-05-29 words: 2944 sentences: 159 pages: flesch: 51 cache: ./cache/cord-017240-2vqehqfh.txt txt: ./txt/cord-017240-2vqehqfh.txt summary: • Evidence level 2-derived from systematic reviews with homogeneity of cohort studies, individual cohorts, and/or poor-quality RCTs. NIV is applied in patients with a "do not intubate" order, as a palliative measure in terminally ill patients, to prevent extubation failure in patients with COPD or heart failure, for communityacquired pneumonia (CAP) in COPD patients, to prevent and treat postoperative respiratory failure, and to prevent ARF due to asthma. [ 2 ] , which included eight RCTs that had studied patients with AHRF secondary to causes other than ACPO, the NIV reduced the ETI rate by 23 %, the length of stay in the intensive care unit (ICU) by 2 days, and ICU mortality by 17 % (absolute risk reduction). [ 8 ] , in a prospective observational study, compared the effi cacy of NIV in patients without COPD but with hypoxemic respiratory failure due to ACPO (15 patients) or severe CAP (18 patients). abstract: The strict range of applicability of noninvasive ventilation (NIV)—which had been applied only to patients with an exacerbation of chronic obstructive pulmonary disease (COPD) or acute cardiogenic pulmonary edema (ACPO)—has been extended during the last two decades. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121750/ doi: 10.1007/978-3-7091-1496-4_7 id: cord-034578-i9rdubix author: Vaschetto, Rosanna title: Outcomes of COVID-19 patients treated with continuous positive airway pressure outside ICU date: 2020-10-30 words: 3678 sentences: 206 pages: flesch: 46 cache: ./cache/cord-034578-i9rdubix.txt txt: ./txt/cord-034578-i9rdubix.txt summary: AIM: We aim at characterising a large population of Coronavirus 19 (COVID-19) patients with moderate-to-severe hypoxemic acute respiratory failure (ARF) receiving CPAP outside intensive care unit (ICU), and ascertaining whether the duration of CPAP application increased the risk of mortality for patients requiring intubation. We designed this retrospective multicentre study to describe the clinical characteristics of patients with laboratory-confirmed COVID-19 treated with CPAP outside ICU, to assess 60-day in-hospital mortality, and hospital length of stay (LOS), and to ascertain whether the duration CPAP application prior to CPAP failure affects outcome in patients requiring endotracheal intubation. This multicentre retrospective observational study on 537 patients hypoxemic ARF secondary to laboratory-confirmed COVID-19 infection, shows that CPAP applied to different therapeutic goals i.e., candidate to intubation in the case of CPAP failure and do-not-intubate in which CPAP is considered the ceiling of treatment, is feasible outside ICU. abstract: AIM: We aim at characterising a large population of Coronavirus 19 (COVID-19) patients with moderate-to-severe hypoxemic acute respiratory failure (ARF) receiving CPAP outside intensive care unit (ICU), and ascertaining whether the duration of CPAP application increased the risk of mortality for patients requiring intubation. METHODS: In this retrospective, multicentre cohort study, we included COVID-19 adult patients, treated with CPAP outside ICU for hypoxemic ARF from March 1(st) to April 15(th), 2020. We collected demographic and clinical data, including CPAP therapeutic goal, hospital length of stay (LOS), and 60-day in-hospital mortality. RESULTS: The study includes 537 patients with a median age of 69 (IQR, 60–76) years. Males were 391 (73%). According to predefined CPAP therapeutic goal, 397 (74%) patients were included in full treatment subgroup, and 140 (26%) in the do-not intubate (DNI) subgroup. Median CPAP duration was 4 (IQR, 1–8) days, while hospital LOS 16 (IQR, 9–27) days. Sixty-day in-hospital mortality was overall 34% (95%CI, 0.304–0.384), and 21% (95%CI, 0.169–0.249) and 73% (95%CI, 0.648–0.787) for full treatment and DNI subgroups, respectively. In the full treatment subgroup, in-hospital mortality was 42% (95%CI, 0.345–0.488) for 180 (45%) CPAP failures requiring intubation, while 2% (95%CI, 0.008–0.035) for the remaining 217 (55%) patients who succeeded. Delaying intubation was associated with increased mortality [HR, 1.093 (95%CI, 1.010–1.184)]. CONCLUSIONS: We described a large population of COVID-19 patients treated with CPAP outside ICU. Intubation delay represents a risk factor for mortality. Further investigation is needed for early identification of CPAP failures. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607967/ doi: 10.1183/23120541.00541-2020 id: cord-009375-2hflah2h author: WANG, Xi-Jun title: Study of Fusion Protein and Attachment Glycoprotein of Nipah Virus Expressed in Recombinant Baculovirus date: 2006-06-15 words: 4482 sentences: 194 pages: flesch: 47 cache: ./cache/cord-009375-2hflah2h.txt txt: ./txt/cord-009375-2hflah2h.txt summary: The envelope attachment glycoprotein (G) and fusion protein (F′) of Nipah virus (NiV) play a key role in viral entry and induction of neutralization antibody. Furthermore, the G and F protein-specific antibodies could neutralize the infectivity of the VSVΔG*F/G, the NiV F and G-envelope glycoproteins of pseudotype recombinant Vesicular Stomatitis Virus expressing green fluorescence protein. Furthermore, the G and F protein-specific antibodies could neutralize the infectivity of the VSVΔG*F/G, the NiV F and G-envelope glycoproteins of pseudotype recombinant Vesicular Stomatitis Virus expressing green fluorescence protein. For detecting reactionogenicity of rNF and rNG expressed by the recombinant baculoviruses, ELISA plates were coated with the lysate of sf9 cells that were infected by rBac-NiV-F and rBac-NiV-G and detected with 1:200 dilution of polyclone serum from rabbits immunized with inactivated NiV (kindly provided by Dr. L. In this study, immunization with insect cells was infected by the recombinant baculoviruses, thereby expressing NiV G and F proteins, eliciting G and F protein-specific antibody responses in mice. abstract: The envelope attachment glycoprotein (G) and fusion protein (F′) of Nipah virus (NiV) play a key role in viral entry and induction of neutralization antibody. In this study, recombinant baculoviruses, rBac-NF and rBac-NG, were generated to express F and G proteins of NiV. The expressions of recombinant G (rNG) and F (rNF) proteins in rBac-NF and rBac-NG-infected cells were confirmed by Western blot. Both rNG and rNF showed sensitive and specific antigenic reaction to rabbit serum anti-Nipah virus in indirect immunofluorescence detection and indirect ELISA. Immunization with rBac-NF and rBac-NG-infected insect cells elicited G and F protein-specific antibody responses in mice. Furthermore, the G and F protein-specific antibodies could neutralize the infectivity of the VSVΔG*F/G, the NiV F and G envelope glycoproteins of pseudotype recombinant Vesicular Stomatitis Virus expressing green fluorescence protein. The results demonstrated that the F and G proteins expressed by the recombinant baculoviruses could be safe diagnostic antigens for the surveillance and monitoring of NiV and could also be promising subunit vaccines for the prevention of NiV. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148955/ doi: 10.1016/s1872-2075(06)60038-1 id: cord-352850-as12ll8s author: Wang, Tao title: Clinical Features of Coronavirus Disease 2019 Patients With Mechanical Ventilation: A Nationwide Study in China date: 2020-06-23 words: 2022 sentences: 109 pages: flesch: 48 cache: ./cache/cord-352850-as12ll8s.txt txt: ./txt/cord-352850-as12ll8s.txt summary: title: Clinical Features of Coronavirus Disease 2019 Patients With Mechanical Ventilation: A Nationwide Study in China Mechanical ventilation is lifesaving for respiratory distress, this study was designed to delineate the clinical features of the coronavirus disease 2019 patients with mechanical ventilation from a national cohort in China. Multivariate regression analysis showed that higher odds of in-hospital death was associated with invasive mechanical ventilation requirement (hazard ratio: 2.95; 95% CI, 1.40–6.23; p = 0.005), and coexisting chronic obstructive pulmonary disease (hazard ratio, 4.57; 95% CI, 1.65–12.69; p = 0.004) and chronic renal disease (hazard ratio, 5.45; 95% CI, 1.85–16.12; p = 0.002). Compared with NIV group, IMV cases had higher levels of lactate dehydrogenase, d-dimer, CRP and WBC count, and lower levels of albumin and oxygenation index (Table E2 , Supplemental Digital Content 1, http://links.lww.com/CCM/ F609); and showed a higher incidence of elevated d-dimer at admission with multivariate logistic regression analysis (>1.5 mg/L; HR, 3.05; 95% CI, 1.07-8.69, p = 0.037) ( Table 1) . abstract: OBJECTIVES: The outbreak of coronavirus disease 2019 is becoming a worldwide pandemic. Mechanical ventilation is lifesaving for respiratory distress, this study was designed to delineate the clinical features of the coronavirus disease 2019 patients with mechanical ventilation from a national cohort in China. DESIGN: Prospective observational study. SETTING: The rapid spread of severe acute respiratory syndrome coronavirus 2 has infected more than 7.7 million people and caused more than 423,000 deaths. PATIENTS: Adult hospitalized coronavirus disease 2019 patients with mechanical ventilation from 557 hospitals from China. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: From a nationwide cohort, 141 coronavirus disease 2019 cases with mechanical ventilation were extracted from 1,590 cases. Cigarette smoke, advanced age, coexisting chronic illness, elevated systolic blood pressure, high body temperature, and abnormal laboratory findings are common in these ventilated cases. Multivariate regression analysis showed that higher odds of in-hospital death was associated with invasive mechanical ventilation requirement (hazard ratio: 2.95; 95% CI, 1.40–6.23; p = 0.005), and coexisting chronic obstructive pulmonary disease (hazard ratio, 4.57; 95% CI, 1.65–12.69; p = 0.004) and chronic renal disease (hazard ratio, 5.45; 95% CI, 1.85–16.12; p = 0.002). Compared with patients with noninvasive mechanical ventilation, patients who needs invasive mechanical ventilation showed higher rate of elevated d-dimer (> 1.5 mg/L) at admission (hazard ratio, 3.28, 95% CI, 1.07–10.10; p = 0.039). CONCLUSIONS: The potential risk factors of elevated d-dimer level could help clinicians to identify invasive mechanical ventilation requirement at an early stage, and coexisting chronic obstructive pulmonary disease or chronic renal disease are independent risk factors associated with fatal outcome in coronavirus disease 2019 patients with mechanical ventilation. url: https://doi.org/10.1097/ccm.0000000000004473 doi: 10.1097/ccm.0000000000004473 id: cord-013149-y0dbhtef author: Wohlfarth, P. title: Hämatoonkologie und Intensivmedizin: Vom Tabu zur Conditio sine qua non date: 2020-10-12 words: 2333 sentences: 260 pages: flesch: 35 cache: ./cache/cord-013149-y0dbhtef.txt txt: ./txt/cord-013149-y0dbhtef.txt summary: Timing der Intensivstationsaufnahme Die vorhandenen Daten über kritisch kranke Krebspatienten mit den häufigsten Intensivstationsaufnahmegründen, ARV und Sepsis, zeigen einmütig, dass eine möglichst frühzeitige Verlegung auf die Intensivstation, also bei manifestem oder eventuell auch nur drohendem Organversagen, erfolgen sollte [8, 9] . Bei Patienten mit "chronic obstructive pulmonary disease" (COPD) und hypertensivem Lungenödem stellt die nichtinvasive Beatmung (NIV) den Goldstandard der Therapie dar und es gibt keine evidenzbasierte Rationale, dass dies nicht auch bei Krebspatienten gelten sollte. These include defining proper goals of intensive care treatment, managing acute respiratory failure with diverse differential considerations, treating immunologic side-effects of ever new and innovative cancer therapies, as well as numerous clinical scenarios which may exclusively arise in cancer patients. Cancer · Intensive care unit · Acute respiratory failure · Immunotherapy · iCHOP und womöglich "um jeden Preis" nicht zu intubieren, kann somit als überholt, ja im Fall sekundärerIntubationenbeiNIV-Versagen sogar als potenziell gefährlich angesehen werden. abstract: Intensivists are confronted with a broad spectrum of specific clinical problems while caring for critically ill cancer patients. These include defining proper goals of intensive care treatment, managing acute respiratory failure with diverse differential considerations, treating immunologic side-effects of ever new and innovative cancer therapies, as well as numerous clinical scenarios which may exclusively arise in cancer patients. To help clinicians handle such challenges, the initiative Intensive Care in Hematologic and Oncologic Patients (iCHOP) has been dealing with these topics for several years. Supported by several Austrian and German medical societies of intensive care medicine, hematology and oncology, the first “Consensus statement for cancer patients requiring intensive care support” has only recently been released. Acute respiratory failure and its management continues to be a major focus in critically ill cancer patients due to its frequency and its prognostic impact. While noninvasive oxygenation strategies were considered the gold standard of therapy, more recent high-quality data do not show clinical benefits of such techniques including high flow nasal oxygen. On the contrary, several studies revealed an unidentified etiology of an acute respiratory failure as the only potentially modifiable risk factor for adverse outcome. Consequently, evidence-based and rigorously applied diagnostic algorithms are of utmost importance in these patients. Furthermore, intensivists are increasingly confronted with the rising incidence of various and new immunotherapy-associated toxicities and their management. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549082/ doi: 10.1007/s00063-020-00737-5 id: cord-027805-p0bhju1s author: Wong, An-Kwok Ian title: Consequences and Solutions for the Impact of Communication Impairment on Noninvasive Ventilation Therapy for Acute Respiratory Failure: A Focused Review date: 2020-06-15 words: 4344 sentences: 239 pages: flesch: 40 cache: ./cache/cord-027805-p0bhju1s.txt txt: ./txt/cord-027805-p0bhju1s.txt summary: DATA SOURCES: We searched MEDLINE and Google Scholar for "speech," "communication," "impairment," "failure," "complications," "NIPPV," "NIV," and "noninvasive ventilation." STUDY SELECTION: We included articles with patients in acute respiratory failure. Analogous communication problems exist with effective solutions in other fields, such as fighter pilot masks, that can be easily implemented to enhance noninvasive ventilation patient care, increase adherence to noninvasive ventilation treatment, and improve patient outcomes. W ith landmark trials demonstrating the efficacy of noninvasive ventilation (NIV) in cardiogenic pulmonary edema and acute exacerbations of chronic obstructive pulmonary disease, NIV has changed the standard of care for acute respiratory failure (ARF) and reduced the amount of invasive mechanical ventilation (IMV) being used (1) (2) (3) (4) . Noninvasive mechanical ventilation via face mask in patients with acute respiratory failure who refused endotracheal intubation abstract: OBJECTIVES: With over 2 million cases of acute respiratory failure in the United States per year, noninvasive ventilation has become a leading treatment modality, often supplanting invasive mechanical ventilation as the initial treatment of choice. Most acute respiratory failure patients use a full face (oronasal) mask with noninvasive ventilation, which is known to impair communication, but its popularity and benefit has led many providers to accept the communication impairment. Medical staff periodically remove masks to communicate with patients, but patients are often limited to short utterances and risk lung derecruitment upon removal of positive pressure. These problems can lead to noninvasive ventilation failure, which is often linked to worse outcomes than first initiating invasive mechanical ventilation and can lead to increased hospitalization costs. DATA SOURCES: We searched MEDLINE and Google Scholar for “speech,” “communication,” “impairment,” “failure,” “complications,” “NIPPV,” “NIV,” and “noninvasive ventilation.” STUDY SELECTION: We included articles with patients in acute respiratory failure. We excluded articles for patients using noninvasive ventilation therapy for obstructive sleep apnea. DATA SYNTHESIS: Communication impairment has been associated with increasing noninvasive ventilation anxiety (odds ratio, 1.25). Of patients using noninvasive ventilation, 48% require early discontinuation, 22% refuse noninvasive ventilation, and 9% are ultimately intubated. Improvements to communication have been shown to reduce fear and anxiety in invasive mechanical ventilation patients. Analogous communication problems exist with effective solutions in other fields, such as fighter pilot masks, that can be easily implemented to enhance noninvasive ventilation patient care, increase adherence to noninvasive ventilation treatment, and improve patient outcomes. CONCLUSIONS: Communication impairment is an underappreciated cause of noninvasive ventilation complications and failure and requires further characterization. Analogous solutions—such as throat microphones and mask-based microphones—that can be easily implemented show potential as cost-effective methods to reduce noninvasive ventilation failure. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314319/ doi: 10.1097/cce.0000000000000121 id: cord-029392-5s5686i9 author: Zayed, Yazan title: Effect of oxygenation modalities among patients with postoperative respiratory failure: a pairwise and network meta-analysis of randomized controlled trials date: 2020-07-17 words: 3974 sentences: 215 pages: flesch: 36 cache: ./cache/cord-029392-5s5686i9.txt txt: ./txt/cord-029392-5s5686i9.txt summary: Our aim is to compare outcomes between non-invasive ventilation (NIV), high-flow nasal cannula (HFNC), and standard oxygen in patients at high-risk for or with established postoperative respiratory failure. We included only randomized controlled trials (RCTs) that compared NIV, HFNC, and standard oxygen in patients at high risk for or with established postoperative respiratory failure. CONCLUSIONS: Among patients with post-operative respiratory failure, HFNC and NIV were associated with significantly reduced rates of intubation and ICU-acquired infections compared with standard oxygen. In this first network meta-analysis comparing various oxygenation strategies in patients at risk for hypoxemic respiratory failure or established respiratory failure within 7 days of surgery, we have found that NIV and HFNC were associated with a significant reduction in intubation rates and ICU-acquired infections when compared to standard oxygen therapy. abstract: BACKGROUND: Postoperative respiratory failure is associated with increased perioperative complications. Our aim is to compare outcomes between non-invasive ventilation (NIV), high-flow nasal cannula (HFNC), and standard oxygen in patients at high-risk for or with established postoperative respiratory failure. METHODS: Electronic databases including PubMed, Embase, and the Cochrane Library were reviewed from inception to September 2019. We included only randomized controlled trials (RCTs) that compared NIV, HFNC, and standard oxygen in patients at high risk for or with established postoperative respiratory failure. We performed a Bayesian network meta-analysis to calculate the odds ratio (OR) and Bayesian 95% credible intervals (CrIs). RESULTS: Nine RCTs representing 1865 patients were included (the mean age was 61.6 ± 10.2 and 64.4% were males). In comparison with standard oxygen, NIV was associated with a significant reduction in intubation rate (OR 0.23; 95% Cr.I. 0.10–0.46), mortality (OR 0.45; 95% Cr.I. 0.27–0.71), and intensive care unit (ICU)-acquired infections (OR 0.43, 95% Cr.I. 0.25–0.70). Compared to standard oxygen, HFNC was associated with a significant reduction in intubation rate (OR 0.28, 95% Cr.I. 0.08–0.76) and ICU-acquired infections (OR 0.41; 95% Cr.I. 0.20–0.80), but not mortality (OR 0.58; 95% Cr.I. 0.26–1.22). There were no significant differences between HFNC and NIV regarding different outcomes. In a subgroup analysis, we observed a mortality benefit with NIV over standard oxygen in patients undergoing cardiothoracic surgeries but not in abdominal surgeries. Furthermore, in comparison with standard oxygen, NIV and HFNC were associated with lower intubation rates following cardiothoracic surgeries while only NIV reduced the intubation rates following abdominal surgeries. CONCLUSIONS: Among patients with post-operative respiratory failure, HFNC and NIV were associated with significantly reduced rates of intubation and ICU-acquired infections compared with standard oxygen. Moreover, NIV was associated with reduced mortality in comparison with standard oxygen. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366473/ doi: 10.1186/s40560-020-00468-x id: cord-000619-3bakci02 author: Zhang, Peng-jun title: Clinical features and risk factors for severe and critical pregnant women with 2009 pandemic H1N1 influenza infection in China date: 2012-02-01 words: 3110 sentences: 212 pages: flesch: 55 cache: ./cache/cord-000619-3bakci02.txt txt: ./txt/cord-000619-3bakci02.txt summary: title: Clinical features and risk factors for severe and critical pregnant women with 2009 pandemic H1N1 influenza infection in China Data on risk factors associated with death of pregnant women and neonates with pH1N1 infections are limited outside of developed countries. METHODS: Retrospective observational study in 394 severe or critical pregnant women admitted to a hospital with pH1N1 influenza from Sep. 1, 2009 to Dec. 31, 2009. Preterm delivery was a risk factor for neonatal death among pregnant women with pH1N1 influenza infection. However, information is limited concerning the risk factors for maternal and neonatal death when pregnancy is complicated by severe or critical illness related to 2009 pH1N1 influenza. In this report, we described the characteristics of pH1N1 influenza in pregnant women and the risk factors for maternal and neonatal death. The clinical data reported herein is consistent with previous studies that demonstrate that pregnant women with influenza are at an increased risk of serious illness and death. abstract: BACKGROUND: 2009 pandemic H1N1 (pH1N1) influenza posed an increased risk of severe illness among pregnant women. Data on risk factors associated with death of pregnant women and neonates with pH1N1 infections are limited outside of developed countries. METHODS: Retrospective observational study in 394 severe or critical pregnant women admitted to a hospital with pH1N1 influenza from Sep. 1, 2009 to Dec. 31, 2009. rRT-PCR testing was used to confirm infection. In-hospital mortality was the primary endpoint of this study. Univariable logistic analysis and multivariate logistic regression analysis were used to investigate the potential factors on admission that might be associated with the maternal and neonatal mortality. RESULTS: 394 pregnant women were included, 286 were infected with pH1N1 in the third trimester. 351 had pneumonia, and 77 died. A PaO(2)/FiO(2 )≤ 200 (odds ratio (OR), 27.16; 95% confidence interval (CI), 2.64-279.70) and higher BMI (i.e. ≥ 30) on admission (OR, 1.26; 95% CI, 1.09 to 1.47) were independent risk factors for maternal death. Of 211 deliveries, 146 neonates survived. Premature delivery (OR, 4.17; 95% CI, 1.19-14.56) was associated neonatal mortality. Among 186 patients who received mechanical ventilation, 83 patients were treated with non-invasive ventilation (NIV) and 38 were successful with NIV. The death rate was lower among patients who initially received NIV than those who were initially intubated (24/83, 28.9% vs 43/87, 49.4%; p = 0.006). Septic shock was an independent risk factor for failure of NIV. CONCLUSIONS: Severe hypoxemia and higher BMI on admission were associated with adverse outcomes for pregnant women. Preterm delivery was a risk factor for neonatal death among pregnant women with pH1N1 influenza infection. NIV may be useful in selected pregnant women without septic shock. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311613/ doi: 10.1186/1471-2334-12-29 id: cord-313639-qpt47sx2 author: Zheng, Yi title: Clinical characteristics of 34 COVID-19 patients admitted to intensive care unit in Hangzhou, China date: 2020-05-20 words: 3723 sentences: 191 pages: flesch: 49 cache: ./cache/cord-313639-qpt47sx2.txt txt: ./txt/cord-313639-qpt47sx2.txt summary: OBJECTIVE: This study summarizes and compares clinical and laboratory characteristics of 34 patients admitted to the intensive care unit (ICU) for complications from coronavirus disease 2019 (COVID-19) at the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China from Jan. 22 to Mar. 5, 2020. For this retrospective study, we analyzed data from patients admitted between Jan. 22 and Mar. 5, 2020, who had been diagnosed (according to the guidance of NHC (2020a)) with SARS-CoV-2 pneumonia in the ICU in the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. In this single-center case series of 34 ICU patients with SARS-CoV-2 infection in Hangzhou, China, 97.1% (33 cases) of patients had complications caused by ARDS, 44.1% (15) received IMV, 55.9% (19) only needed noninvasive respiratory support. abstract: OBJECTIVE: This study summarizes and compares clinical and laboratory characteristics of 34 patients admitted to the intensive care unit (ICU) for complications from coronavirus disease 2019 (COVID-19) at the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China from Jan. 22 to Mar. 5, 2020. METHODS: A total of 34 patients were divided into two groups, including those who required noninvasive ventilation (NIV) and invasive mechanical ventilation (IMV) with additional extracorporeal membrane oxygenation (ECMO) in 11 patients. Clinical features of COVID-19 patients were described and the parameters of clinical characteristics between the two groups were compared. RESULTS: The rates of the acute cardiac and kidney complications were higher in IMV cases than those in NIV cases. Most patients had lymphocytopenia on admission, with lymphocyte levels dropping progressively on the following days, and the more severe lymphopenia developed in the IMV group. In both groups, T lymphocyte counts were below typical lower limit norms compared to B lymphocytes. On admission, both groups had higher than expected amounts of plasma interleukin-6 (IL-6), which over time declined more in NIV patients. The prothrombin time was increased and the levels of platelet, hemoglobin, blood urea nitrogen (BUN), D-dimer, lactate dehydrogenase (LDH), and IL-6 were higher in IMV cases compared with NIV cases during hospitalization CONCLUSIONS: Data showed that the rates of complications, dynamics of lymphocytopenia, and changes in levels of platelet, hemoglobin, BUN, D-dimer, LDH and IL-6, and prothrombin time in these ICU patients were significantly different between IMV and NIV cases. url: https://doi.org/10.1631/jzus.b2000174 doi: 10.1631/jzus.b2000174 id: cord-027526-ohcu28rk author: Zhou, Xiaoyang title: Preventive use of respiratory support after scheduled extubation in critically ill medical patients—a network meta-analysis of randomized controlled trials date: 2020-06-22 words: 6436 sentences: 329 pages: flesch: 44 cache: ./cache/cord-027526-ohcu28rk.txt txt: ./txt/cord-027526-ohcu28rk.txt summary: METHODS: A systematic database search was performed from inception to December 19, 2019, for randomized controlled trials (RCTs) that compared a preventive use of different respiratory support methods, including conventional oxygen therapy (COT), noninvasive ventilation (NIV), high-flow oxygen therapy (HFOT), and combinational use of HFOT and NIV (HFOT+NIV), after planned extubation in adult critically ill medical patients. Nevertheless, the latest meta-analysis [19] of randomized controlled trials (RCTs) suggested that compared to COT, preventive use of NIV after extubation had no effect on the re-intubation rate or mortality in post-extubated patients. Relevant studies regarding preventive use of various respiratory support methods, including COT, NIV, HFOT, and HFOT+NIV, after planned extubation in critically ill medical patients were searched systematically by two independent reviewers (Xu Z and Chen B) from database inception through December 19, 2019, in PubMed, Embase, Web of Science, and Cochrane Central Register of Controlled Trials. abstract: BACKGROUND: Respiratory support has been increasingly used after extubation for the prevention of re-intubation and improvement of prognosis in critically ill medical patients. However, the optimal respiratory support method is still under debate. This network meta-analysis (NMA) aims to evaluate the comparative effectiveness of various respiratory support methods used for preventive purposes after scheduled extubation in critically ill medical patients. METHODS: A systematic database search was performed from inception to December 19, 2019, for randomized controlled trials (RCTs) that compared a preventive use of different respiratory support methods, including conventional oxygen therapy (COT), noninvasive ventilation (NIV), high-flow oxygen therapy (HFOT), and combinational use of HFOT and NIV (HFOT+NIV), after planned extubation in adult critically ill medical patients. Study selection, data extraction, and quality assessments were performed in duplicate. The primary outcomes included re-intubation rate and short-term mortality. RESULTS: Seventeen RCTs comprising 3341 participants with 4 comparisons were included. Compared with COT, NIV significantly reduced the re-intubation rate [risk ratio (RR) 0.55, 95% confidence interval (CI) 0.39 to 0.77; moderate quality of evidence] and short-term mortality (RR 0.66, 95% CI 0.48 to 0.91; moderate quality of evidence). Compared to COT, HFOT had a beneficial effect on the re-intubation rate (RR 0.55, 95% CI 0.35 to 0.86; moderate quality of evidence) but no effect on short-term mortality (RR 0.79, 95% CI 0.56 to 1.12; low quality of evidence). No significant difference in the re-intubation rate or short-term mortality was found among NIV, HFOT, and HFOT+NIV. The treatment rankings based on the surface under the cumulative ranking curve (SUCRA) from best to worst for re-intubation rate were HFOT+NIV (95.1%), NIV (53.4%), HFOT (51.2%), and COT (0.3%), and the rankings for short-term mortality were NIV (91.0%), HFOT (54.3%), HFOT+NIV (43.7%), and COT (11.1%). Sensitivity analyses of trials with a high risk of extubation failure for the primary outcomes indicated that the SUCRA rankings were comparable to those of the primary analysis. CONCLUSIONS: After scheduled extubation, the preventive use of NIV is probably the most effective respiratory support method for comprehensively preventing re-intubation and short-term death in critically ill medical patients, especially those with a high risk of extubation failure. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306939/ doi: 10.1186/s13054-020-03090-3 id: cord-005727-li8pwigg author: nan title: ESICM 2010 MONDAY SESSIONS 11 October 2010 date: 2010-08-31 words: 102770 sentences: 6408 pages: flesch: 53 cache: ./cache/cord-005727-li8pwigg.txt txt: ./txt/cord-005727-li8pwigg.txt summary: Since, continuous epidural analgesia provides the required level of analgesia to support early mobilization and significant reduction in pulmonary and cardiovascular morbidity in the early postoperative period, we postulated that the use of low dose of continuous epidural morphine might improve postoperative analgesia and reduce undesirable side effects in elderly patientsTherefore, the present study was designed to evaluate the effects of morphine administered via epidural patients controlled analgesia and intravenous tramadol + metamizol on postoperative pain control and side effects in elderly patients after major abdominal surgery. For each ventilated patient the following data was registered:Age, APACHE II, the reason of admission, risk factors, use NIV, MV duration, timing of tracheostomy, time of diagnosis of VAP, microbiological data, length of stay and mortality in ICU. 23rd ESICM ANNUAL CONGRESS -BARCELONA, SPAIN -9-13 OCTOBER 2010 S131 Evaluated factors: patient characteristics, signs, symptoms, abscess location, time between symptoms and hospital admission and surgery, lab results, microbiology, antibiotic therapy, APACHE2, SAPS2, SOFA, length of ICU stay, surgical re-intervention, duration of mechanical ventilation, infectious complications, critical illness myopathy (CIM), renal replacement therapy (RRT), re-intubation, tracheotomy, mortality. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095301/ doi: 10.1007/s00134-010-1999-x id: cord-335975-m6lkrehi author: nan title: Proceedings of Réanimation 2018, the French Intensive Care Society International Congress date: 2018-02-05 words: 89374 sentences: 5327 pages: flesch: 52 cache: ./cache/cord-335975-m6lkrehi.txt txt: ./txt/cord-335975-m6lkrehi.txt summary: A qSOFA score relying on 3 simple clinical criteria (respiratory rate, mental status and systolic blood pressure) has been proposed to better identify septic patients with associated higher mortality outside the intensive care unit (Seymour CW et al., JAMA 2016) . We propose to determine whether the arterial oxygen pressure (PaO2) at intensive care unit (ICU) admission affects mortality at day 28 (D28) in patients with septic shock subjected to mechanical out-of-hospital ventilation. Conclusion: In this study, we report a significant association between hyperoxemia at ICU admission and mortality at D28 in patients with septic shock subjected to pre-hospital invasive mechanical ventilation. The aim of this study was to describe outcome of pediatric patient with hematologic disease hospitalized in our intensive care unit for respiratory failure and to investigate the clinical variables associated with mortality. abstract: nan url: https://doi.org/10.1186/s13613-017-0345-7 doi: 10.1186/s13613-017-0345-7 id: cord-355038-o2hr5mox author: nan title: Proceedings of Réanimation 2020, the French Intensive Care Society International Congress date: 2020-02-11 words: 102485 sentences: 7028 pages: flesch: 52 cache: ./cache/cord-355038-o2hr5mox.txt txt: ./txt/cord-355038-o2hr5mox.txt summary: Conclusion: In patients with moderate-to-severe ARDS, a higher tidal volume under PSV within the 72 h following neuromuscular blockers cessation is independently associated with the 28-day mortality.Compliance with ethics regulations: Yes. Kaplan-Meier estimate of the cumulative probability of survival according to the mean tidal volume (Vt)-lower of higher than 8 ml/ kg-under pressure support ventilation (PSV) during the "transition period" transfusion is associated with adverse events, and equipoise remains on the optimal transfusion strategy in oncologic patients in surgical setting. Compliance with ethics regulations: Yes. Patients and methods: In a retrospective monocentric study (01/2013-01/2017) conducted in cardio-vascular surgical intensive care unit (ICU) in Henri Mondor teaching hospital, all consecutive adult patients who underwent peripheral VA-ECMO were included, with exclusion of those dying in the first 24 h. Compliance with ethics regulations: Yes. Rationale: Acute respiratory failure is the leading reason for intensive care unit (ICU) admission in immunocompromised patients and the need for invasive mechanical ventilation has become a major clinical end-point in randomized controlled trials (RCT). abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32048060/ doi: 10.1186/s13613-020-0623-7 ==== make-pages.sh questions [ERIC WAS HERE] ==== make-pages.sh search /data-disk/reader-compute/reader-cord/bin/make-pages.sh: line 77: /data-disk/reader-compute/reader-cord/tmp/search.htm: No such file or directory Traceback (most recent call last): File "/data-disk/reader-compute/reader-cord/bin/tsv2htm-search.py", line 51, in with open( TEMPLATE, 'r' ) as handle : htm = handle.read() FileNotFoundError: [Errno 2] No such file or directory: '/data-disk/reader-compute/reader-cord/tmp/search.htm' ==== make-pages.sh topic modeling corpus Zipping study carrel