id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-102749-tgka0pl0	Tovo, Anna	Taxonomic classification method for metagenomics based on core protein families with Core-Kaiju	2020-05-01		.txt	text/plain	7844	352	47	In this study, we first apply and compare different bioinformatics methods based on 16S ribosomal RNA gene and whole genome shotgun sequencing for taxonomic classification to three small mock communities of bacteria, of which the compositions are known. In particular, we propose an updated version of Kaiju, which combines the power of shotgun metagenomics data with a more focused marker gene classification method, similar to 16S rRNA, but based on core protein domain families (40, 41, 42, 43) from the PFAM database (44) . As shown in (27) , where different amplicon sequencing methods are tested on both simulated and real data and the results are compared to those obtained with metagenomic pipelines, the whole genome approach resulted to outperform the previous ones in terms of both number of identified strains, taxonomic and functional resolution and reliability on estimates of microbial relative abundance distribution in samples.	./cache/cord-102749-tgka0pl0.txt	./txt/cord-102749-tgka0pl0.txt