id sid tid token lemma pos cord-048446-gaemgm0t 1 1 key key JJ cord-048446-gaemgm0t 1 2 : : : cord-048446-gaemgm0t 1 3 cord-048446-gaemgm0 cord-048446-gaemgm0 NNP cord-048446-gaemgm0t 1 4 t t NN cord-048446-gaemgm0t 1 5 authors author NNS cord-048446-gaemgm0t 1 6 : : : cord-048446-gaemgm0t 1 7 White White NNP cord-048446-gaemgm0t 1 8 , , , cord-048446-gaemgm0t 1 9 Laura Laura NNP cord-048446-gaemgm0t 1 10 Forsberg Forsberg NNP cord-048446-gaemgm0t 1 11 ; ; : cord-048446-gaemgm0t 1 12 Pagano Pagano NNP cord-048446-gaemgm0t 1 13 , , , cord-048446-gaemgm0t 1 14 Marcello Marcello NNP cord-048446-gaemgm0t 1 15 title title NN cord-048446-gaemgm0t 1 16 : : : cord-048446-gaemgm0t 1 17 Transmissibility transmissibility NN cord-048446-gaemgm0t 1 18 of of IN cord-048446-gaemgm0t 1 19 the the DT cord-048446-gaemgm0t 1 20 Influenza Influenza NNP cord-048446-gaemgm0t 1 21 Virus Virus NNP cord-048446-gaemgm0t 1 22 in in IN cord-048446-gaemgm0t 1 23 the the DT cord-048446-gaemgm0t 1 24 1918 1918 CD cord-048446-gaemgm0t 1 25 Pandemic Pandemic NNP cord-048446-gaemgm0t 1 26 date date NN cord-048446-gaemgm0t 1 27 : : : cord-048446-gaemgm0t 1 28 2008 2008 CD cord-048446-gaemgm0t 1 29 - - SYM cord-048446-gaemgm0t 1 30 01 01 CD cord-048446-gaemgm0t 1 31 - - SYM cord-048446-gaemgm0t 1 32 30 30 CD cord-048446-gaemgm0t 1 33 journal journal NN cord-048446-gaemgm0t 1 34 : : : cord-048446-gaemgm0t 2 1 PLoS PLoS NNP cord-048446-gaemgm0t 2 2 One one CD cord-048446-gaemgm0t 2 3 DOI DOI NNP cord-048446-gaemgm0t 2 4 : : : cord-048446-gaemgm0t 2 5 10.1371 10.1371 CD cord-048446-gaemgm0t 2 6 / / SYM cord-048446-gaemgm0t 2 7 journal.pone.0001498 journal.pone.0001498 NNP cord-048446-gaemgm0t 2 8 sha sha NNP cord-048446-gaemgm0t 2 9 : : : cord-048446-gaemgm0t 2 10 16ffa1f7efaf96880e6f3c22d2de9c5672169303 16ffa1f7efaf96880e6f3c22d2de9c5672169303 RB cord-048446-gaemgm0t 2 11 doc_id doc_id CD cord-048446-gaemgm0t 2 12 : : : cord-048446-gaemgm0t 2 13 48446 48446 CD cord-048446-gaemgm0t 2 14 cord_uid cord_uid NNS cord-048446-gaemgm0t 2 15 : : : cord-048446-gaemgm0t 3 1 gaemgm0 gaemgm0 NNP cord-048446-gaemgm0t 4 1 t t NNP cord-048446-gaemgm0t 4 2 BACKGROUND BACKGROUND NNP cord-048446-gaemgm0t 4 3 : : : cord-048446-gaemgm0t 5 1 With with IN cord-048446-gaemgm0t 5 2 a a DT cord-048446-gaemgm0t 5 3 heightened heightened JJ cord-048446-gaemgm0t 5 4 increase increase NN cord-048446-gaemgm0t 5 5 in in IN cord-048446-gaemgm0t 5 6 concern concern NN cord-048446-gaemgm0t 5 7 for for IN cord-048446-gaemgm0t 5 8 an an DT cord-048446-gaemgm0t 5 9 influenza influenza NN cord-048446-gaemgm0t 5 10 pandemic pandemic NN cord-048446-gaemgm0t 5 11 we -PRON- PRP cord-048446-gaemgm0t 5 12 sought seek VBD cord-048446-gaemgm0t 5 13 to to TO cord-048446-gaemgm0t 5 14 better better RB cord-048446-gaemgm0t 5 15 understand understand VB cord-048446-gaemgm0t 5 16 the the DT cord-048446-gaemgm0t 5 17 1918 1918 CD cord-048446-gaemgm0t 5 18 Influenza Influenza NNP cord-048446-gaemgm0t 5 19 pandemic pandemic NN cord-048446-gaemgm0t 5 20 , , , cord-048446-gaemgm0t 5 21 the the DT cord-048446-gaemgm0t 5 22 most most RBS cord-048446-gaemgm0t 5 23 devastating devastating JJ cord-048446-gaemgm0t 5 24 epidemic epidemic NN cord-048446-gaemgm0t 5 25 of of IN cord-048446-gaemgm0t 5 26 the the DT cord-048446-gaemgm0t 5 27 previous previous JJ cord-048446-gaemgm0t 5 28 century century NN cord-048446-gaemgm0t 5 29 . . . cord-048446-gaemgm0t 6 1 METHODOLOGY/ METHODOLOGY/ NNP cord-048446-gaemgm0t 7 1 PRINCIPAL principal NN cord-048446-gaemgm0t 7 2 FINDINGS finding NNS cord-048446-gaemgm0t 7 3 : : : cord-048446-gaemgm0t 8 1 We -PRON- PRP cord-048446-gaemgm0t 8 2 use use VBP cord-048446-gaemgm0t 8 3 data datum NNS cord-048446-gaemgm0t 8 4 from from IN cord-048446-gaemgm0t 8 5 several several JJ cord-048446-gaemgm0t 8 6 communities community NNS cord-048446-gaemgm0t 8 7 in in IN cord-048446-gaemgm0t 8 8 Maryland Maryland NNP cord-048446-gaemgm0t 8 9 , , , cord-048446-gaemgm0t 8 10 USA USA NNP cord-048446-gaemgm0t 8 11 as as RB cord-048446-gaemgm0t 8 12 well well RB cord-048446-gaemgm0t 8 13 as as IN cord-048446-gaemgm0t 8 14 two two CD cord-048446-gaemgm0t 8 15 ships ship NNS cord-048446-gaemgm0t 8 16 that that WDT cord-048446-gaemgm0t 8 17 experienced experience VBD cord-048446-gaemgm0t 8 18 well well RB cord-048446-gaemgm0t 8 19 - - HYPH cord-048446-gaemgm0t 8 20 documented document VBN cord-048446-gaemgm0t 8 21 outbreaks outbreak NNS cord-048446-gaemgm0t 8 22 of of IN cord-048446-gaemgm0t 8 23 influenza influenza NN cord-048446-gaemgm0t 8 24 in in IN cord-048446-gaemgm0t 8 25 1918 1918 CD cord-048446-gaemgm0t 8 26 . . . cord-048446-gaemgm0t 9 1 Using use VBG cord-048446-gaemgm0t 9 2 a a DT cord-048446-gaemgm0t 9 3 likelihood likelihood NN cord-048446-gaemgm0t 9 4 - - HYPH cord-048446-gaemgm0t 9 5 based base VBN cord-048446-gaemgm0t 9 6 method method NN cord-048446-gaemgm0t 9 7 and and CC cord-048446-gaemgm0t 9 8 a a DT cord-048446-gaemgm0t 9 9 nonparametric nonparametric JJ cord-048446-gaemgm0t 9 10 method method NN cord-048446-gaemgm0t 9 11 , , , cord-048446-gaemgm0t 9 12 we -PRON- PRP cord-048446-gaemgm0t 9 13 estimate estimate VBP cord-048446-gaemgm0t 9 14 the the DT cord-048446-gaemgm0t 9 15 serial serial JJ cord-048446-gaemgm0t 9 16 interval interval NN cord-048446-gaemgm0t 9 17 and and CC cord-048446-gaemgm0t 9 18 reproductive reproductive JJ cord-048446-gaemgm0t 9 19 number number NN cord-048446-gaemgm0t 9 20 throughout throughout IN cord-048446-gaemgm0t 9 21 the the DT cord-048446-gaemgm0t 9 22 course course NN cord-048446-gaemgm0t 9 23 of of IN cord-048446-gaemgm0t 9 24 each each DT cord-048446-gaemgm0t 9 25 outbreak outbreak NN cord-048446-gaemgm0t 9 26 . . . cord-048446-gaemgm0t 10 1 This this DT cord-048446-gaemgm0t 10 2 analysis analysis NN cord-048446-gaemgm0t 10 3 shows show VBZ cord-048446-gaemgm0t 10 4 the the DT cord-048446-gaemgm0t 10 5 basic basic JJ cord-048446-gaemgm0t 10 6 reproductive reproductive JJ cord-048446-gaemgm0t 10 7 number number NN cord-048446-gaemgm0t 10 8 to to TO cord-048446-gaemgm0t 10 9 be be VB cord-048446-gaemgm0t 10 10 slightly slightly RB cord-048446-gaemgm0t 10 11 lower low JJR cord-048446-gaemgm0t 10 12 in in IN cord-048446-gaemgm0t 10 13 the the DT cord-048446-gaemgm0t 10 14 Maryland Maryland NNP cord-048446-gaemgm0t 10 15 communities community NNS cord-048446-gaemgm0t 10 16 ( ( -LRB- cord-048446-gaemgm0t 10 17 between between IN cord-048446-gaemgm0t 10 18 1.34 1.34 CD cord-048446-gaemgm0t 10 19 and and CC cord-048446-gaemgm0t 10 20 3.21 3.21 CD cord-048446-gaemgm0t 10 21 ) ) -RRB- cord-048446-gaemgm0t 10 22 than than IN cord-048446-gaemgm0t 10 23 for for IN cord-048446-gaemgm0t 10 24 the the DT cord-048446-gaemgm0t 10 25 enclosed enclose VBN cord-048446-gaemgm0t 10 26 populations population NNS cord-048446-gaemgm0t 10 27 on on IN cord-048446-gaemgm0t 10 28 the the DT cord-048446-gaemgm0t 10 29 ships ship NNS cord-048446-gaemgm0t 10 30 ( ( -LRB- cord-048446-gaemgm0t 10 31 R(0 R(0 NNP cord-048446-gaemgm0t 10 32 ) ) -RRB- cord-048446-gaemgm0t 10 33 = = NFP cord-048446-gaemgm0t 11 1 4.97 4.97 CD cord-048446-gaemgm0t 11 2 , , , cord-048446-gaemgm0t 11 3 SE SE NNP cord-048446-gaemgm0t 11 4 = = SYM cord-048446-gaemgm0t 11 5 3.31 3.31 CD cord-048446-gaemgm0t 11 6 ) ) -RRB- cord-048446-gaemgm0t 11 7 . . . cord-048446-gaemgm0t 12 1 Additionally additionally RB cord-048446-gaemgm0t 12 2 the the DT cord-048446-gaemgm0t 12 3 effective effective JJ cord-048446-gaemgm0t 12 4 reproductive reproductive JJ cord-048446-gaemgm0t 12 5 number number NN cord-048446-gaemgm0t 12 6 declined decline VBD cord-048446-gaemgm0t 12 7 to to TO cord-048446-gaemgm0t 12 8 sub sub VB cord-048446-gaemgm0t 12 9 epidemic epidemic JJ cord-048446-gaemgm0t 12 10 levels level NNS cord-048446-gaemgm0t 12 11 more more RBR cord-048446-gaemgm0t 12 12 quickly quickly RB cord-048446-gaemgm0t 12 13 on on IN cord-048446-gaemgm0t 12 14 the the DT cord-048446-gaemgm0t 12 15 ships ship NNS cord-048446-gaemgm0t 12 16 ( ( -LRB- cord-048446-gaemgm0t 12 17 within within IN cord-048446-gaemgm0t 12 18 around around RB cord-048446-gaemgm0t 12 19 10 10 CD cord-048446-gaemgm0t 12 20 days day NNS cord-048446-gaemgm0t 12 21 ) ) -RRB- cord-048446-gaemgm0t 12 22 than than IN cord-048446-gaemgm0t 12 23 in in IN cord-048446-gaemgm0t 12 24 the the DT cord-048446-gaemgm0t 12 25 communities community NNS cord-048446-gaemgm0t 12 26 ( ( -LRB- cord-048446-gaemgm0t 12 27 within within IN cord-048446-gaemgm0t 12 28 30–40 30–40 CD cord-048446-gaemgm0t 12 29 days day NNS cord-048446-gaemgm0t 12 30 ) ) -RRB- cord-048446-gaemgm0t 12 31 . . . cord-048446-gaemgm0t 13 1 The the DT cord-048446-gaemgm0t 13 2 mean mean JJ cord-048446-gaemgm0t 13 3 serial serial JJ cord-048446-gaemgm0t 13 4 interval interval NN cord-048446-gaemgm0t 13 5 for for IN cord-048446-gaemgm0t 13 6 the the DT cord-048446-gaemgm0t 13 7 ships ship NNS cord-048446-gaemgm0t 13 8 was be VBD cord-048446-gaemgm0t 13 9 consistent consistent JJ cord-048446-gaemgm0t 13 10 ( ( -LRB- cord-048446-gaemgm0t 13 11 3.33 3.33 CD cord-048446-gaemgm0t 13 12 , , , cord-048446-gaemgm0t 13 13 SE SE NNP cord-048446-gaemgm0t 13 14 = = SYM cord-048446-gaemgm0t 13 15 5.96 5.96 CD cord-048446-gaemgm0t 13 16 and and CC cord-048446-gaemgm0t 13 17 3.81 3.81 CD cord-048446-gaemgm0t 13 18 , , , cord-048446-gaemgm0t 13 19 SE SE NNP cord-048446-gaemgm0t 13 20 = = SYM cord-048446-gaemgm0t 13 21 3.69 3.69 CD cord-048446-gaemgm0t 13 22 ) ) -RRB- cord-048446-gaemgm0t 13 23 , , , cord-048446-gaemgm0t 13 24 while while IN cord-048446-gaemgm0t 13 25 the the DT cord-048446-gaemgm0t 13 26 serial serial JJ cord-048446-gaemgm0t 13 27 intervals interval NNS cord-048446-gaemgm0t 13 28 in in IN cord-048446-gaemgm0t 13 29 the the DT cord-048446-gaemgm0t 13 30 communities community NNS cord-048446-gaemgm0t 13 31 varied vary VBN cord-048446-gaemgm0t 13 32 substantially substantially RB cord-048446-gaemgm0t 13 33 ( ( -LRB- cord-048446-gaemgm0t 13 34 between between IN cord-048446-gaemgm0t 13 35 2.83 2.83 CD cord-048446-gaemgm0t 13 36 , , , cord-048446-gaemgm0t 13 37 SE se NN cord-048446-gaemgm0t 13 38 = = SYM cord-048446-gaemgm0t 13 39 0.53 0.53 CD cord-048446-gaemgm0t 13 40 and and CC cord-048446-gaemgm0t 13 41 8.28 8.28 CD cord-048446-gaemgm0t 13 42 , , , cord-048446-gaemgm0t 13 43 SE SE NNP cord-048446-gaemgm0t 13 44 = = SYM cord-048446-gaemgm0t 13 45 951.95 951.95 CD cord-048446-gaemgm0t 13 46 ) ) -RRB- cord-048446-gaemgm0t 13 47 . . . cord-048446-gaemgm0t 14 1 CONCLUSIONS conclusion NNS cord-048446-gaemgm0t 14 2 / / SYM cord-048446-gaemgm0t 14 3 SIGNIFICANCE significance NN cord-048446-gaemgm0t 14 4 : : : cord-048446-gaemgm0t 15 1 These these DT cord-048446-gaemgm0t 15 2 results result NNS cord-048446-gaemgm0t 15 3 illustrate illustrate VBP cord-048446-gaemgm0t 15 4 the the DT cord-048446-gaemgm0t 15 5 importance importance NN cord-048446-gaemgm0t 15 6 of of IN cord-048446-gaemgm0t 15 7 considering consider VBG cord-048446-gaemgm0t 15 8 the the DT cord-048446-gaemgm0t 15 9 population population NN cord-048446-gaemgm0t 15 10 dynamics dynamic NNS cord-048446-gaemgm0t 15 11 when when WRB cord-048446-gaemgm0t 15 12 making make VBG cord-048446-gaemgm0t 15 13 statements statement NNS cord-048446-gaemgm0t 15 14 about about IN cord-048446-gaemgm0t 15 15 the the DT cord-048446-gaemgm0t 15 16 epidemiological epidemiological JJ cord-048446-gaemgm0t 15 17 parameters parameter NNS cord-048446-gaemgm0t 15 18 of of IN cord-048446-gaemgm0t 15 19 Influenza Influenza NNP cord-048446-gaemgm0t 15 20 . . . cord-048446-gaemgm0t 16 1 The the DT cord-048446-gaemgm0t 16 2 methods method NNS cord-048446-gaemgm0t 16 3 that that WDT cord-048446-gaemgm0t 16 4 we -PRON- PRP cord-048446-gaemgm0t 16 5 employ employ VBP cord-048446-gaemgm0t 16 6 for for IN cord-048446-gaemgm0t 16 7 estimation estimation NN cord-048446-gaemgm0t 16 8 of of IN cord-048446-gaemgm0t 16 9 the the DT cord-048446-gaemgm0t 16 10 reproductive reproductive JJ cord-048446-gaemgm0t 16 11 numbers number NNS cord-048446-gaemgm0t 16 12 and and CC cord-048446-gaemgm0t 16 13 the the DT cord-048446-gaemgm0t 16 14 serial serial JJ cord-048446-gaemgm0t 16 15 interval interval NN cord-048446-gaemgm0t 16 16 can can MD cord-048446-gaemgm0t 16 17 be be VB cord-048446-gaemgm0t 16 18 easily easily RB cord-048446-gaemgm0t 16 19 replicated replicate VBN cord-048446-gaemgm0t 16 20 in in IN cord-048446-gaemgm0t 16 21 other other JJ cord-048446-gaemgm0t 16 22 populations population NNS cord-048446-gaemgm0t 16 23 and and CC cord-048446-gaemgm0t 16 24 with with IN cord-048446-gaemgm0t 16 25 other other JJ cord-048446-gaemgm0t 16 26 diseases disease NNS cord-048446-gaemgm0t 16 27 . . . cord-048446-gaemgm0t 17 1 The the DT cord-048446-gaemgm0t 17 2 emergence emergence NN cord-048446-gaemgm0t 17 3 of of IN cord-048446-gaemgm0t 17 4 the the DT cord-048446-gaemgm0t 17 5 highly highly RB cord-048446-gaemgm0t 17 6 pathogenic pathogenic JJ cord-048446-gaemgm0t 17 7 avian avian JJ cord-048446-gaemgm0t 17 8 influenza influenza NN cord-048446-gaemgm0t 17 9 strain strain VB cord-048446-gaemgm0t 17 10 H5N1 H5N1 NNP cord-048446-gaemgm0t 17 11 has have VBZ cord-048446-gaemgm0t 17 12 raised raise VBN cord-048446-gaemgm0t 17 13 concerns concern NNS cord-048446-gaemgm0t 17 14 of of IN cord-048446-gaemgm0t 17 15 an an DT cord-048446-gaemgm0t 17 16 imminent imminent JJ cord-048446-gaemgm0t 17 17 influenza influenza NN cord-048446-gaemgm0t 17 18 pandemic pandemic NN cord-048446-gaemgm0t 17 19 . . . cord-048446-gaemgm0t 18 1 Public public JJ cord-048446-gaemgm0t 18 2 health health NN cord-048446-gaemgm0t 18 3 workers worker NNS cord-048446-gaemgm0t 18 4 , , , cord-048446-gaemgm0t 18 5 government government NN cord-048446-gaemgm0t 18 6 officials official NNS cord-048446-gaemgm0t 18 7 and and CC cord-048446-gaemgm0t 18 8 disaster disaster NN cord-048446-gaemgm0t 18 9 planners planner NNS cord-048446-gaemgm0t 18 10 have have VBP cord-048446-gaemgm0t 18 11 an an DT cord-048446-gaemgm0t 18 12 increasing increase VBG cord-048446-gaemgm0t 18 13 interest interest NN cord-048446-gaemgm0t 18 14 in in IN cord-048446-gaemgm0t 18 15 better well JJR cord-048446-gaemgm0t 18 16 understanding understand VBG cord-048446-gaemgm0t 18 17 the the DT cord-048446-gaemgm0t 18 18 potential potential JJ cord-048446-gaemgm0t 18 19 impact impact NN cord-048446-gaemgm0t 18 20 of of IN cord-048446-gaemgm0t 18 21 an an DT cord-048446-gaemgm0t 18 22 influenza influenza NN cord-048446-gaemgm0t 18 23 pandemic pandemic NN cord-048446-gaemgm0t 18 24 and and CC cord-048446-gaemgm0t 18 25 possible possible JJ cord-048446-gaemgm0t 18 26 strategies strategy NNS cord-048446-gaemgm0t 18 27 for for IN cord-048446-gaemgm0t 18 28 containment containment NN cord-048446-gaemgm0t 18 29 . . . cord-048446-gaemgm0t 19 1 Crucial crucial JJ cord-048446-gaemgm0t 19 2 in in IN cord-048446-gaemgm0t 19 3 this this DT cord-048446-gaemgm0t 19 4 planning planning NN cord-048446-gaemgm0t 19 5 is be VBZ cord-048446-gaemgm0t 19 6 an an DT cord-048446-gaemgm0t 19 7 understanding understanding NN cord-048446-gaemgm0t 19 8 of of IN cord-048446-gaemgm0t 19 9 the the DT cord-048446-gaemgm0t 19 10 basic basic JJ cord-048446-gaemgm0t 19 11 epidemiology epidemiology NN cord-048446-gaemgm0t 19 12 of of IN cord-048446-gaemgm0t 19 13 the the DT cord-048446-gaemgm0t 19 14 disease disease NN cord-048446-gaemgm0t 19 15 in in IN cord-048446-gaemgm0t 19 16 various various JJ cord-048446-gaemgm0t 19 17 settings setting NNS cord-048446-gaemgm0t 19 18 . . . cord-048446-gaemgm0t 20 1 This this DT cord-048446-gaemgm0t 20 2 has have VBZ cord-048446-gaemgm0t 20 3 led lead VBN cord-048446-gaemgm0t 20 4 to to IN cord-048446-gaemgm0t 20 5 a a DT cord-048446-gaemgm0t 20 6 growing grow VBG cord-048446-gaemgm0t 20 7 interest interest NN cord-048446-gaemgm0t 20 8 in in IN cord-048446-gaemgm0t 20 9 the the DT cord-048446-gaemgm0t 20 10 analysis analysis NN cord-048446-gaemgm0t 20 11 and and CC cord-048446-gaemgm0t 20 12 understanding understanding NN cord-048446-gaemgm0t 20 13 of of IN cord-048446-gaemgm0t 20 14 past past JJ cord-048446-gaemgm0t 20 15 epidemics epidemic NNS cord-048446-gaemgm0t 20 16 , , , cord-048446-gaemgm0t 20 17 particularly particularly RB cord-048446-gaemgm0t 20 18 that that IN cord-048446-gaemgm0t 20 19 of of IN cord-048446-gaemgm0t 20 20 1918 1918 CD cord-048446-gaemgm0t 20 21 , , , cord-048446-gaemgm0t 20 22 the the DT cord-048446-gaemgm0t 20 23 most most RBS cord-048446-gaemgm0t 20 24 virulent virulent JJ cord-048446-gaemgm0t 20 25 and and CC cord-048446-gaemgm0t 20 26 deadly deadly JJ cord-048446-gaemgm0t 20 27 influenza influenza NN cord-048446-gaemgm0t 20 28 epidemic epidemic NN cord-048446-gaemgm0t 20 29 of of IN cord-048446-gaemgm0t 20 30 the the DT cord-048446-gaemgm0t 20 31 20th 20th JJ cord-048446-gaemgm0t 20 32 century century NN cord-048446-gaemgm0t 20 33 . . . cord-048446-gaemgm0t 21 1 Mortality mortality NN cord-048446-gaemgm0t 21 2 has have VBZ cord-048446-gaemgm0t 21 3 been be VBN cord-048446-gaemgm0t 21 4 estimated estimate VBN cord-048446-gaemgm0t 21 5 at at IN cord-048446-gaemgm0t 21 6 50 50 CD cord-048446-gaemgm0t 21 7 - - SYM cord-048446-gaemgm0t 21 8 100 100 CD cord-048446-gaemgm0t 21 9 million million CD cord-048446-gaemgm0t 21 10 people people NNS cord-048446-gaemgm0t 21 11 worldwide worldwide RB cord-048446-gaemgm0t 21 12 as as IN cord-048446-gaemgm0t 21 13 a a DT cord-048446-gaemgm0t 21 14 result result NN cord-048446-gaemgm0t 21 15 of of IN cord-048446-gaemgm0t 21 16 influenza influenza NN cord-048446-gaemgm0t 21 17 in in IN cord-048446-gaemgm0t 21 18 the the DT cord-048446-gaemgm0t 21 19 1918 1918 CD cord-048446-gaemgm0t 21 20 pandemic pandemic NN cord-048446-gaemgm0t 21 21 [ [ -LRB- cord-048446-gaemgm0t 21 22 1 1 CD cord-048446-gaemgm0t 21 23 ] ] -RRB- cord-048446-gaemgm0t 21 24 . . . cord-048446-gaemgm0t 22 1 It -PRON- PRP cord-048446-gaemgm0t 22 2 is be VBZ cord-048446-gaemgm0t 22 3 reasonable reasonable JJ cord-048446-gaemgm0t 22 4 to to TO cord-048446-gaemgm0t 22 5 suppose suppose VB cord-048446-gaemgm0t 22 6 that that IN cord-048446-gaemgm0t 22 7 by by IN cord-048446-gaemgm0t 22 8 better well JJR cord-048446-gaemgm0t 22 9 understanding understand VBG cord-048446-gaemgm0t 22 10 the the DT cord-048446-gaemgm0t 22 11 transmission transmission NN cord-048446-gaemgm0t 22 12 dynamics dynamic NNS cord-048446-gaemgm0t 22 13 of of IN cord-048446-gaemgm0t 22 14 the the DT cord-048446-gaemgm0t 22 15 highly highly RB cord-048446-gaemgm0t 22 16 pathogenic pathogenic JJ cord-048446-gaemgm0t 22 17 virus virus NN cord-048446-gaemgm0t 22 18 in in IN cord-048446-gaemgm0t 22 19 1918 1918 CD cord-048446-gaemgm0t 22 20 , , , cord-048446-gaemgm0t 22 21 we -PRON- PRP cord-048446-gaemgm0t 22 22 can can MD cord-048446-gaemgm0t 22 23 gain gain VB cord-048446-gaemgm0t 22 24 greater great JJR cord-048446-gaemgm0t 22 25 insight insight NN cord-048446-gaemgm0t 22 26 into into IN cord-048446-gaemgm0t 22 27 the the DT cord-048446-gaemgm0t 22 28 dynamics dynamic NNS cord-048446-gaemgm0t 22 29 , , , cord-048446-gaemgm0t 22 30 and and CC cord-048446-gaemgm0t 22 31 thus thus RB cord-048446-gaemgm0t 22 32 potential potential JJ cord-048446-gaemgm0t 22 33 methods method NNS cord-048446-gaemgm0t 22 34 of of IN cord-048446-gaemgm0t 22 35 control control NN cord-048446-gaemgm0t 22 36 , , , cord-048446-gaemgm0t 22 37 for for IN cord-048446-gaemgm0t 22 38 a a DT cord-048446-gaemgm0t 22 39 future future JJ cord-048446-gaemgm0t 22 40 pandemic pandemic NN cord-048446-gaemgm0t 22 41 [ [ -LRB- cord-048446-gaemgm0t 22 42 2 2 CD cord-048446-gaemgm0t 22 43 ] ] -RRB- cord-048446-gaemgm0t 22 44 . . . cord-048446-gaemgm0t 23 1 Important important JJ cord-048446-gaemgm0t 23 2 parameters parameter NNS cord-048446-gaemgm0t 23 3 for for IN cord-048446-gaemgm0t 23 4 understanding understand VBG cord-048446-gaemgm0t 23 5 disease disease NN cord-048446-gaemgm0t 23 6 transmission transmission NN cord-048446-gaemgm0t 23 7 are be VBP cord-048446-gaemgm0t 23 8 the the DT cord-048446-gaemgm0t 23 9 reproductive reproductive JJ cord-048446-gaemgm0t 23 10 number number NN cord-048446-gaemgm0t 23 11 and and CC cord-048446-gaemgm0t 23 12 the the DT cord-048446-gaemgm0t 23 13 serial serial JJ cord-048446-gaemgm0t 23 14 interval interval NN cord-048446-gaemgm0t 23 15 [ [ -LRB- cord-048446-gaemgm0t 23 16 3 3 CD cord-048446-gaemgm0t 23 17 ] ] -RRB- cord-048446-gaemgm0t 23 18 . . . cord-048446-gaemgm0t 24 1 The the DT cord-048446-gaemgm0t 24 2 basic basic JJ cord-048446-gaemgm0t 24 3 reproductive reproductive JJ cord-048446-gaemgm0t 24 4 number number NN cord-048446-gaemgm0t 24 5 is be VBZ cord-048446-gaemgm0t 24 6 defined define VBN cord-048446-gaemgm0t 24 7 as as IN cord-048446-gaemgm0t 24 8 the the DT cord-048446-gaemgm0t 24 9 average average JJ cord-048446-gaemgm0t 24 10 number number NN cord-048446-gaemgm0t 24 11 of of IN cord-048446-gaemgm0t 24 12 secondary secondary JJ cord-048446-gaemgm0t 24 13 infections infection NNS cord-048446-gaemgm0t 24 14 created create VBN cord-048446-gaemgm0t 24 15 from from IN cord-048446-gaemgm0t 24 16 a a DT cord-048446-gaemgm0t 24 17 primary primary JJ cord-048446-gaemgm0t 24 18 infection infection NN cord-048446-gaemgm0t 24 19 in in IN cord-048446-gaemgm0t 24 20 an an DT cord-048446-gaemgm0t 24 21 entirely entirely RB cord-048446-gaemgm0t 24 22 susceptible susceptible JJ cord-048446-gaemgm0t 24 23 population population NN cord-048446-gaemgm0t 24 24 [ [ -LRB- cord-048446-gaemgm0t 24 25 4 4 CD cord-048446-gaemgm0t 24 26 , , , cord-048446-gaemgm0t 24 27 see see VB cord-048446-gaemgm0t 24 28 also also RB cord-048446-gaemgm0t 24 29 5 5 CD cord-048446-gaemgm0t 24 30 ] ] -RRB- cord-048446-gaemgm0t 24 31 . . . cord-048446-gaemgm0t 25 1 A a DT cord-048446-gaemgm0t 25 2 more more RBR cord-048446-gaemgm0t 25 3 complex complex JJ cord-048446-gaemgm0t 25 4 , , , cord-048446-gaemgm0t 25 5 but but CC cord-048446-gaemgm0t 25 6 perhaps perhaps RB cord-048446-gaemgm0t 25 7 meaningful meaningful JJ cord-048446-gaemgm0t 25 8 parameter parameter NN cord-048446-gaemgm0t 25 9 is be VBZ cord-048446-gaemgm0t 25 10 the the DT cord-048446-gaemgm0t 25 11 effective effective JJ cord-048446-gaemgm0t 25 12 reproductive reproductive JJ cord-048446-gaemgm0t 25 13 number number NN cord-048446-gaemgm0t 25 14 which which WDT cord-048446-gaemgm0t 25 15 defines define VBZ cord-048446-gaemgm0t 25 16 the the DT cord-048446-gaemgm0t 25 17 average average JJ cord-048446-gaemgm0t 25 18 number number NN cord-048446-gaemgm0t 25 19 of of IN cord-048446-gaemgm0t 25 20 secondary secondary JJ cord-048446-gaemgm0t 25 21 infections infection NNS cord-048446-gaemgm0t 25 22 an an DT cord-048446-gaemgm0t 25 23 infected infected JJ cord-048446-gaemgm0t 25 24 will will MD cord-048446-gaemgm0t 25 25 create create VB cord-048446-gaemgm0t 25 26 at at IN cord-048446-gaemgm0t 25 27 a a DT cord-048446-gaemgm0t 25 28 given give VBN cord-048446-gaemgm0t 25 29 point point NN cord-048446-gaemgm0t 25 30 in in IN cord-048446-gaemgm0t 25 31 the the DT cord-048446-gaemgm0t 25 32 epidemic epidemic NN cord-048446-gaemgm0t 25 33 . . . cord-048446-gaemgm0t 26 1 This this DT cord-048446-gaemgm0t 26 2 parameter parameter NN cord-048446-gaemgm0t 26 3 takes take VBZ cord-048446-gaemgm0t 26 4 into into IN cord-048446-gaemgm0t 26 5 account account NN cord-048446-gaemgm0t 26 6 that that IN cord-048446-gaemgm0t 26 7 not not RB cord-048446-gaemgm0t 26 8 all all DT cord-048446-gaemgm0t 26 9 contacts contact NNS cord-048446-gaemgm0t 26 10 of of IN cord-048446-gaemgm0t 26 11 an an DT cord-048446-gaemgm0t 26 12 infected infected JJ cord-048446-gaemgm0t 26 13 individual individual NN cord-048446-gaemgm0t 26 14 are be VBP cord-048446-gaemgm0t 26 15 with with IN cord-048446-gaemgm0t 26 16 susceptible susceptible JJ cord-048446-gaemgm0t 26 17 persons person NNS cord-048446-gaemgm0t 26 18 , , , cord-048446-gaemgm0t 26 19 as as RB cord-048446-gaemgm0t 26 20 well well RB cord-048446-gaemgm0t 26 21 as as IN cord-048446-gaemgm0t 26 22 the the DT cord-048446-gaemgm0t 26 23 impact impact NN cord-048446-gaemgm0t 26 24 of of IN cord-048446-gaemgm0t 26 25 public public JJ cord-048446-gaemgm0t 26 26 health health NN cord-048446-gaemgm0t 26 27 control control NN cord-048446-gaemgm0t 26 28 measures measure NNS cord-048446-gaemgm0t 26 29 . . . cord-048446-gaemgm0t 27 1 Control control NN cord-048446-gaemgm0t 27 2 strategies strategy NNS cord-048446-gaemgm0t 27 3 are be VBP cord-048446-gaemgm0t 27 4 typically typically RB cord-048446-gaemgm0t 27 5 targeted target VBN cord-048446-gaemgm0t 27 6 to to TO cord-048446-gaemgm0t 27 7 drive drive VB cord-048446-gaemgm0t 27 8 this this DT cord-048446-gaemgm0t 27 9 number number NN cord-048446-gaemgm0t 27 10 below below IN cord-048446-gaemgm0t 27 11 one one CD cord-048446-gaemgm0t 27 12 and and CC cord-048446-gaemgm0t 27 13 maintain maintain VB cord-048446-gaemgm0t 27 14 it -PRON- PRP cord-048446-gaemgm0t 27 15 there there RB cord-048446-gaemgm0t 27 16 , , , cord-048446-gaemgm0t 27 17 as as IN cord-048446-gaemgm0t 27 18 this this DT cord-048446-gaemgm0t 27 19 will will MD cord-048446-gaemgm0t 27 20 lead lead VB cord-048446-gaemgm0t 27 21 to to IN cord-048446-gaemgm0t 27 22 eventual eventual JJ cord-048446-gaemgm0t 27 23 extinction extinction NN cord-048446-gaemgm0t 27 24 of of IN cord-048446-gaemgm0t 27 25 the the DT cord-048446-gaemgm0t 27 26 epidemic epidemic NN cord-048446-gaemgm0t 27 27 . . . cord-048446-gaemgm0t 28 1 An an DT cord-048446-gaemgm0t 28 2 example example NN cord-048446-gaemgm0t 28 3 of of IN cord-048446-gaemgm0t 28 4 this this DT cord-048446-gaemgm0t 28 5 is be VBZ cord-048446-gaemgm0t 28 6 herd herd NN cord-048446-gaemgm0t 28 7 immunity immunity NN cord-048446-gaemgm0t 28 8 , , , cord-048446-gaemgm0t 28 9 or or CC cord-048446-gaemgm0t 28 10 immunity immunity NN cord-048446-gaemgm0t 28 11 to to IN cord-048446-gaemgm0t 28 12 a a DT cord-048446-gaemgm0t 28 13 disease disease NN cord-048446-gaemgm0t 28 14 that that WDT cord-048446-gaemgm0t 28 15 is be VBZ cord-048446-gaemgm0t 28 16 incurred incur VBN cord-048446-gaemgm0t 28 17 from from IN cord-048446-gaemgm0t 28 18 a a DT cord-048446-gaemgm0t 28 19 sufficiently sufficiently RB cord-048446-gaemgm0t 28 20 large large JJ cord-048446-gaemgm0t 28 21 proportion proportion NN cord-048446-gaemgm0t 28 22 of of IN cord-048446-gaemgm0t 28 23 the the DT cord-048446-gaemgm0t 28 24 population population NN cord-048446-gaemgm0t 28 25 being be VBG cord-048446-gaemgm0t 28 26 immune immune JJ cord-048446-gaemgm0t 28 27 to to IN cord-048446-gaemgm0t 28 28 a a DT cord-048446-gaemgm0t 28 29 disease disease NN cord-048446-gaemgm0t 28 30 . . . cord-048446-gaemgm0t 29 1 Modeling modeling NN cord-048446-gaemgm0t 29 2 techniques technique NNS cord-048446-gaemgm0t 29 3 are be VBP cord-048446-gaemgm0t 29 4 often often RB cord-048446-gaemgm0t 29 5 used use VBN cord-048446-gaemgm0t 29 6 to to TO cord-048446-gaemgm0t 29 7 determine determine VB cord-048446-gaemgm0t 29 8 the the DT cord-048446-gaemgm0t 29 9 proportion proportion NN cord-048446-gaemgm0t 29 10 of of IN cord-048446-gaemgm0t 29 11 the the DT cord-048446-gaemgm0t 29 12 population population NN cord-048446-gaemgm0t 29 13 that that WDT cord-048446-gaemgm0t 29 14 should should MD cord-048446-gaemgm0t 29 15 be be VB cord-048446-gaemgm0t 29 16 vaccinated vaccinate VBN cord-048446-gaemgm0t 29 17 in in IN cord-048446-gaemgm0t 29 18 order order NN cord-048446-gaemgm0t 29 19 to to TO cord-048446-gaemgm0t 29 20 have have VB cord-048446-gaemgm0t 29 21 the the DT cord-048446-gaemgm0t 29 22 reproductive reproductive JJ cord-048446-gaemgm0t 29 23 number number NN cord-048446-gaemgm0t 29 24 low low JJ cord-048446-gaemgm0t 29 25 enough enough RB cord-048446-gaemgm0t 29 26 to to TO cord-048446-gaemgm0t 29 27 avoid avoid VB cord-048446-gaemgm0t 29 28 outbreaks outbreak NNS cord-048446-gaemgm0t 29 29 of of IN cord-048446-gaemgm0t 29 30 disease disease NN cord-048446-gaemgm0t 29 31 [ [ -LRB- cord-048446-gaemgm0t 29 32 6 6 CD cord-048446-gaemgm0t 29 33 ] ] -RRB- cord-048446-gaemgm0t 29 34 . . . cord-048446-gaemgm0t 30 1 The the DT cord-048446-gaemgm0t 30 2 serial serial JJ cord-048446-gaemgm0t 30 3 interval interval NN cord-048446-gaemgm0t 30 4 can can MD cord-048446-gaemgm0t 30 5 be be VB cord-048446-gaemgm0t 30 6 defined define VBN cord-048446-gaemgm0t 30 7 as as IN cord-048446-gaemgm0t 30 8 the the DT cord-048446-gaemgm0t 30 9 time time NN cord-048446-gaemgm0t 30 10 interval interval NN cord-048446-gaemgm0t 30 11 between between IN cord-048446-gaemgm0t 30 12 a a DT cord-048446-gaemgm0t 30 13 primary primary JJ cord-048446-gaemgm0t 30 14 case case NN cord-048446-gaemgm0t 30 15 presenting present VBG cord-048446-gaemgm0t 30 16 with with IN cord-048446-gaemgm0t 30 17 symptoms symptom NNS cord-048446-gaemgm0t 30 18 and and CC cord-048446-gaemgm0t 30 19 its -PRON- PRP$ cord-048446-gaemgm0t 30 20 infectee infectee NN cord-048446-gaemgm0t 30 21 developing develop VBG cord-048446-gaemgm0t 30 22 symptoms symptom NNS cord-048446-gaemgm0t 30 23 [ [ -LRB- cord-048446-gaemgm0t 30 24 7 7 CD cord-048446-gaemgm0t 30 25 , , , cord-048446-gaemgm0t 30 26 8 8 CD cord-048446-gaemgm0t 30 27 ] ] -RRB- cord-048446-gaemgm0t 30 28 . . . cord-048446-gaemgm0t 31 1 Thus thus RB cord-048446-gaemgm0t 31 2 this this DT cord-048446-gaemgm0t 31 3 quantity quantity NN cord-048446-gaemgm0t 31 4 is be VBZ cord-048446-gaemgm0t 31 5 completely completely RB cord-048446-gaemgm0t 31 6 observable observable JJ cord-048446-gaemgm0t 31 7 . . . cord-048446-gaemgm0t 32 1 This this DT cord-048446-gaemgm0t 32 2 is be VBZ cord-048446-gaemgm0t 32 3 a a DT cord-048446-gaemgm0t 32 4 mixture mixture NN cord-048446-gaemgm0t 32 5 of of IN cord-048446-gaemgm0t 32 6 the the DT cord-048446-gaemgm0t 32 7 incubation incubation NN cord-048446-gaemgm0t 32 8 period period NN cord-048446-gaemgm0t 32 9 and and CC cord-048446-gaemgm0t 32 10 the the DT cord-048446-gaemgm0t 32 11 infectious infectious JJ cord-048446-gaemgm0t 32 12 period period NN cord-048446-gaemgm0t 32 13 , , , cord-048446-gaemgm0t 32 14 both both DT cord-048446-gaemgm0t 32 15 of of IN cord-048446-gaemgm0t 32 16 which which WDT cord-048446-gaemgm0t 32 17 are be VBP cord-048446-gaemgm0t 32 18 useful useful JJ cord-048446-gaemgm0t 32 19 to to TO cord-048446-gaemgm0t 32 20 understand understand VB cord-048446-gaemgm0t 32 21 , , , cord-048446-gaemgm0t 32 22 but but CC cord-048446-gaemgm0t 32 23 difficult difficult JJ cord-048446-gaemgm0t 32 24 to to TO cord-048446-gaemgm0t 32 25 measure measure VB cord-048446-gaemgm0t 32 26 . . . cord-048446-gaemgm0t 33 1 The the DT cord-048446-gaemgm0t 33 2 SARS SARS NNP cord-048446-gaemgm0t 33 3 outbreak outbreak NN cord-048446-gaemgm0t 33 4 of of IN cord-048446-gaemgm0t 33 5 2003 2003 CD cord-048446-gaemgm0t 33 6 had have VBD cord-048446-gaemgm0t 33 7 a a DT cord-048446-gaemgm0t 33 8 relatively relatively RB cord-048446-gaemgm0t 33 9 long long JJ cord-048446-gaemgm0t 33 10 serial serial JJ cord-048446-gaemgm0t 33 11 interval interval NN cord-048446-gaemgm0t 33 12 , , , cord-048446-gaemgm0t 33 13 estimated estimate VBN cord-048446-gaemgm0t 33 14 to to TO cord-048446-gaemgm0t 33 15 be be VB cord-048446-gaemgm0t 33 16 between between IN cord-048446-gaemgm0t 33 17 8 8 CD cord-048446-gaemgm0t 33 18 and and CC cord-048446-gaemgm0t 33 19 10 10 CD cord-048446-gaemgm0t 33 20 days day NNS cord-048446-gaemgm0t 33 21 on on IN cord-048446-gaemgm0t 33 22 average average JJ cord-048446-gaemgm0t 33 23 and and CC cord-048446-gaemgm0t 33 24 following follow VBG cord-048446-gaemgm0t 33 25 a a DT cord-048446-gaemgm0t 33 26 Weibull Weibull NNP cord-048446-gaemgm0t 33 27 distribution distribution NN cord-048446-gaemgm0t 33 28 [ [ -LRB- cord-048446-gaemgm0t 33 29 9 9 CD cord-048446-gaemgm0t 33 30 ] ] -RRB- cord-048446-gaemgm0t 33 31 making make VBG cord-048446-gaemgm0t 33 32 case case NN cord-048446-gaemgm0t 33 33 isolation isolation NN cord-048446-gaemgm0t 33 34 extremely extremely RB cord-048446-gaemgm0t 33 35 effective effective JJ cord-048446-gaemgm0t 33 36 in in IN cord-048446-gaemgm0t 33 37 containing contain VBG cord-048446-gaemgm0t 33 38 the the DT cord-048446-gaemgm0t 33 39 epidemic epidemic NN cord-048446-gaemgm0t 33 40 . . . cord-048446-gaemgm0t 34 1 Methods method NNS cord-048446-gaemgm0t 34 2 for for IN cord-048446-gaemgm0t 34 3 the the DT cord-048446-gaemgm0t 34 4 estimation estimation NN cord-048446-gaemgm0t 34 5 of of IN cord-048446-gaemgm0t 34 6 basic basic JJ cord-048446-gaemgm0t 34 7 epidemiological epidemiological JJ cord-048446-gaemgm0t 34 8 parameters parameter NNS cord-048446-gaemgm0t 34 9 are be VBP cord-048446-gaemgm0t 34 10 still still RB cord-048446-gaemgm0t 34 11 in in IN cord-048446-gaemgm0t 34 12 development development NN cord-048446-gaemgm0t 34 13 phase phase NN cord-048446-gaemgm0t 34 14 . . . cord-048446-gaemgm0t 35 1 [ [ -LRB- cord-048446-gaemgm0t 35 2 10 10 CD cord-048446-gaemgm0t 35 3 ] ] -RRB- cord-048446-gaemgm0t 35 4 provides provide VBZ cord-048446-gaemgm0t 35 5 a a DT cord-048446-gaemgm0t 35 6 thoughtful thoughtful JJ cord-048446-gaemgm0t 35 7 summary summary NN cord-048446-gaemgm0t 35 8 of of IN cord-048446-gaemgm0t 35 9 methods method NNS cord-048446-gaemgm0t 35 10 for for IN cord-048446-gaemgm0t 35 11 estimating estimate VBG cord-048446-gaemgm0t 35 12 the the DT cord-048446-gaemgm0t 35 13 reproductive reproductive JJ cord-048446-gaemgm0t 35 14 number number NN cord-048446-gaemgm0t 35 15 . . . cord-048446-gaemgm0t 36 1 One one CD cord-048446-gaemgm0t 36 2 particularly particularly RB cord-048446-gaemgm0t 36 3 interesting interesting JJ cord-048446-gaemgm0t 36 4 and and CC cord-048446-gaemgm0t 36 5 useful useful JJ cord-048446-gaemgm0t 36 6 method method NN cord-048446-gaemgm0t 36 7 has have VBZ cord-048446-gaemgm0t 36 8 been be VBN cord-048446-gaemgm0t 36 9 previously previously RB cord-048446-gaemgm0t 36 10 described describe VBN cord-048446-gaemgm0t 36 11 by by IN cord-048446-gaemgm0t 36 12 [ [ -LRB- cord-048446-gaemgm0t 36 13 7 7 CD cord-048446-gaemgm0t 36 14 ] ] -RRB- cord-048446-gaemgm0t 36 15 for for IN cord-048446-gaemgm0t 36 16 estimating estimate VBG cord-048446-gaemgm0t 36 17 the the DT cord-048446-gaemgm0t 36 18 daily daily JJ cord-048446-gaemgm0t 36 19 reproductive reproductive JJ cord-048446-gaemgm0t 36 20 number number NN cord-048446-gaemgm0t 36 21 , , , cord-048446-gaemgm0t 36 22 R r NN cord-048446-gaemgm0t 36 23 t t NN cord-048446-gaemgm0t 36 24 , , , cord-048446-gaemgm0t 36 25 or or CC cord-048446-gaemgm0t 36 26 the the DT cord-048446-gaemgm0t 36 27 average average JJ cord-048446-gaemgm0t 36 28 number number NN cord-048446-gaemgm0t 36 29 of of IN cord-048446-gaemgm0t 36 30 cases case NNS cord-048446-gaemgm0t 36 31 an an DT cord-048446-gaemgm0t 36 32 infected infected JJ cord-048446-gaemgm0t 36 33 individual individual NN cord-048446-gaemgm0t 36 34 on on IN cord-048446-gaemgm0t 36 35 day day NN cord-048446-gaemgm0t 36 36 t t NN cord-048446-gaemgm0t 36 37 would would MD cord-048446-gaemgm0t 36 38 cause cause VB cord-048446-gaemgm0t 36 39 . . . cord-048446-gaemgm0t 37 1 One one CD cord-048446-gaemgm0t 37 2 interesting interesting JJ cord-048446-gaemgm0t 37 3 feature feature NN cord-048446-gaemgm0t 37 4 of of IN cord-048446-gaemgm0t 37 5 this this DT cord-048446-gaemgm0t 37 6 method method NN cord-048446-gaemgm0t 37 7 is be VBZ cord-048446-gaemgm0t 37 8 that that IN cord-048446-gaemgm0t 37 9 for for IN cord-048446-gaemgm0t 37 10 days day NNS cord-048446-gaemgm0t 37 11 where where WRB cord-048446-gaemgm0t 37 12 no no DT cord-048446-gaemgm0t 37 13 cases case NNS cord-048446-gaemgm0t 37 14 are be VBP cord-048446-gaemgm0t 37 15 observed observe VBN cord-048446-gaemgm0t 37 16 , , , cord-048446-gaemgm0t 37 17 the the DT cord-048446-gaemgm0t 37 18 estimated estimate VBN cord-048446-gaemgm0t 37 19 effective effective JJ cord-048446-gaemgm0t 37 20 reproductive reproductive JJ cord-048446-gaemgm0t 37 21 number number NN cord-048446-gaemgm0t 37 22 is be VBZ cord-048446-gaemgm0t 37 23 zero zero CD cord-048446-gaemgm0t 37 24 . . . cord-048446-gaemgm0t 38 1 Another another DT cord-048446-gaemgm0t 38 2 observation observation NN cord-048446-gaemgm0t 38 3 is be VBZ cord-048446-gaemgm0t 38 4 that that IN cord-048446-gaemgm0t 38 5 this this DT cord-048446-gaemgm0t 38 6 method method NN cord-048446-gaemgm0t 38 7 essentially essentially RB cord-048446-gaemgm0t 38 8 estimates estimate VBZ cord-048446-gaemgm0t 38 9 a a DT cord-048446-gaemgm0t 38 10 curve curve NN cord-048446-gaemgm0t 38 11 for for IN cord-048446-gaemgm0t 38 12 the the DT cord-048446-gaemgm0t 38 13 effective effective JJ cord-048446-gaemgm0t 38 14 reproductive reproductive JJ cord-048446-gaemgm0t 38 15 number number NN cord-048446-gaemgm0t 38 16 that that WDT cord-048446-gaemgm0t 38 17 traces trace VBZ cord-048446-gaemgm0t 38 18 the the DT cord-048446-gaemgm0t 38 19 epidemic epidemic NN cord-048446-gaemgm0t 38 20 curve curve NN cord-048446-gaemgm0t 38 21 , , , cord-048446-gaemgm0t 38 22 lagged lag VBN cord-048446-gaemgm0t 38 23 by by IN cord-048446-gaemgm0t 38 24 the the DT cord-048446-gaemgm0t 38 25 average average JJ cord-048446-gaemgm0t 38 26 serial serial JJ cord-048446-gaemgm0t 38 27 interval interval NN cord-048446-gaemgm0t 38 28 length length NN cord-048446-gaemgm0t 38 29 . . . cord-048446-gaemgm0t 39 1 This this DT cord-048446-gaemgm0t 39 2 nonparametric nonparametric JJ cord-048446-gaemgm0t 39 3 method method NN cord-048446-gaemgm0t 39 4 presupposes presuppose VBZ cord-048446-gaemgm0t 39 5 information information NN cord-048446-gaemgm0t 39 6 on on IN cord-048446-gaemgm0t 39 7 the the DT cord-048446-gaemgm0t 39 8 serial serial JJ cord-048446-gaemgm0t 39 9 interval interval NN cord-048446-gaemgm0t 39 10 distribution distribution NN cord-048446-gaemgm0t 39 11 . . . cord-048446-gaemgm0t 40 1 This this DT cord-048446-gaemgm0t 40 2 is be VBZ cord-048446-gaemgm0t 40 3 typical typical JJ cord-048446-gaemgm0t 40 4 as as IN cord-048446-gaemgm0t 40 5 most most JJS cord-048446-gaemgm0t 40 6 methods method NNS cord-048446-gaemgm0t 40 7 for for IN cord-048446-gaemgm0t 40 8 estimating estimate VBG cord-048446-gaemgm0t 40 9 the the DT cord-048446-gaemgm0t 40 10 reproductive reproductive JJ cord-048446-gaemgm0t 40 11 number number NN cord-048446-gaemgm0t 40 12 rely rely VBP cord-048446-gaemgm0t 40 13 on on IN cord-048446-gaemgm0t 40 14 knowledge knowledge NN cord-048446-gaemgm0t 40 15 of of IN cord-048446-gaemgm0t 40 16 the the DT cord-048446-gaemgm0t 40 17 serial serial JJ cord-048446-gaemgm0t 40 18 interval interval NN cord-048446-gaemgm0t 40 19 . . . cord-048446-gaemgm0t 41 1 Few few JJ cord-048446-gaemgm0t 41 2 have have VBP cord-048446-gaemgm0t 41 3 described describe VBN cord-048446-gaemgm0t 41 4 analytical analytical JJ cord-048446-gaemgm0t 41 5 methods method NNS cord-048446-gaemgm0t 41 6 for for IN cord-048446-gaemgm0t 41 7 estimating estimate VBG cord-048446-gaemgm0t 41 8 the the DT cord-048446-gaemgm0t 41 9 serial serial JJ cord-048446-gaemgm0t 41 10 interval interval NN cord-048446-gaemgm0t 41 11 , , , cord-048446-gaemgm0t 41 12 making make VBG cord-048446-gaemgm0t 41 13 most most JJS cord-048446-gaemgm0t 41 14 methodologies methodology NNS cord-048446-gaemgm0t 41 15 dependent dependent JJ cord-048446-gaemgm0t 41 16 on on IN cord-048446-gaemgm0t 41 17 contact contact NN cord-048446-gaemgm0t 41 18 tracing trace VBG cord-048446-gaemgm0t 41 19 data datum NNS cord-048446-gaemgm0t 41 20 , , , cord-048446-gaemgm0t 41 21 which which WDT cord-048446-gaemgm0t 41 22 is be VBZ cord-048446-gaemgm0t 41 23 often often RB cord-048446-gaemgm0t 41 24 difficult difficult JJ cord-048446-gaemgm0t 41 25 and and CC cord-048446-gaemgm0t 41 26 expensive expensive JJ cord-048446-gaemgm0t 41 27 to to TO cord-048446-gaemgm0t 41 28 attain attain VB cord-048446-gaemgm0t 41 29 . . . cord-048446-gaemgm0t 42 1 [ [ -LRB- cord-048446-gaemgm0t 42 2 11 11 CD cord-048446-gaemgm0t 42 3 ] ] -RRB- cord-048446-gaemgm0t 42 4 describe describe VB cord-048446-gaemgm0t 42 5 a a DT cord-048446-gaemgm0t 42 6 method method NN cord-048446-gaemgm0t 42 7 to to TO cord-048446-gaemgm0t 42 8 estimate estimate VB cord-048446-gaemgm0t 42 9 the the DT cord-048446-gaemgm0t 42 10 reproductive reproductive JJ cord-048446-gaemgm0t 42 11 number number NN cord-048446-gaemgm0t 42 12 that that WDT cord-048446-gaemgm0t 42 13 relies rely VBZ cord-048446-gaemgm0t 42 14 on on IN cord-048446-gaemgm0t 42 15 limited limited JJ cord-048446-gaemgm0t 42 16 contact contact NN cord-048446-gaemgm0t 42 17 tracing trace VBG cord-048446-gaemgm0t 42 18 information information NN cord-048446-gaemgm0t 42 19 but but CC cord-048446-gaemgm0t 42 20 not not RB cord-048446-gaemgm0t 42 21 a a DT cord-048446-gaemgm0t 42 22 full full JJ cord-048446-gaemgm0t 42 23 estimate estimate NN cord-048446-gaemgm0t 42 24 of of IN cord-048446-gaemgm0t 42 25 the the DT cord-048446-gaemgm0t 42 26 serial serial JJ cord-048446-gaemgm0t 42 27 interval interval NN cord-048446-gaemgm0t 42 28 . . . cord-048446-gaemgm0t 43 1 [ [ -LRB- cord-048446-gaemgm0t 43 2 12 12 CD cord-048446-gaemgm0t 43 3 ] ] -RRB- cord-048446-gaemgm0t 43 4 have have VBP cord-048446-gaemgm0t 43 5 recently recently RB cord-048446-gaemgm0t 43 6 described describe VBN cord-048446-gaemgm0t 43 7 a a DT cord-048446-gaemgm0t 43 8 method method NN cord-048446-gaemgm0t 43 9 to to TO cord-048446-gaemgm0t 43 10 estimate estimate VB cord-048446-gaemgm0t 43 11 the the DT cord-048446-gaemgm0t 43 12 serial serial JJ cord-048446-gaemgm0t 43 13 interval interval NN cord-048446-gaemgm0t 43 14 and and CC cord-048446-gaemgm0t 43 15 then then RB cord-048446-gaemgm0t 43 16 used use VBD cord-048446-gaemgm0t 43 17 this this DT cord-048446-gaemgm0t 43 18 estimate estimate NN cord-048446-gaemgm0t 43 19 with with IN cord-048446-gaemgm0t 43 20 the the DT cord-048446-gaemgm0t 43 21 estimator estimator NN cord-048446-gaemgm0t 43 22 proposed propose VBN cord-048446-gaemgm0t 43 23 in in IN cord-048446-gaemgm0t 43 24 [ [ -LRB- cord-048446-gaemgm0t 43 25 7 7 CD cord-048446-gaemgm0t 43 26 ] ] -RRB- cord-048446-gaemgm0t 43 27 of of IN cord-048446-gaemgm0t 43 28 the the DT cord-048446-gaemgm0t 43 29 daily daily JJ cord-048446-gaemgm0t 43 30 reproductive reproductive JJ cord-048446-gaemgm0t 43 31 number number NN cord-048446-gaemgm0t 43 32 and and CC cord-048446-gaemgm0t 43 33 have have VBP cord-048446-gaemgm0t 43 34 applied apply VBN cord-048446-gaemgm0t 43 35 their -PRON- PRP$ cord-048446-gaemgm0t 43 36 method method NN cord-048446-gaemgm0t 43 37 to to IN cord-048446-gaemgm0t 43 38 data datum NNS cord-048446-gaemgm0t 43 39 from from IN cord-048446-gaemgm0t 43 40 outbreaks outbreak NNS cord-048446-gaemgm0t 43 41 of of IN cord-048446-gaemgm0t 43 42 avian avian JJ cord-048446-gaemgm0t 43 43 influenza influenza NN cord-048446-gaemgm0t 43 44 in in IN cord-048446-gaemgm0t 43 45 poultry poultry NN cord-048446-gaemgm0t 43 46 farms farm NNS cord-048446-gaemgm0t 43 47 in in IN cord-048446-gaemgm0t 43 48 Europe Europe NNP cord-048446-gaemgm0t 43 49 . . . cord-048446-gaemgm0t 44 1 Several several JJ cord-048446-gaemgm0t 44 2 researchers researcher NNS cord-048446-gaemgm0t 44 3 have have VBP cord-048446-gaemgm0t 44 4 studied study VBN cord-048446-gaemgm0t 44 5 the the DT cord-048446-gaemgm0t 44 6 1918 1918 CD cord-048446-gaemgm0t 44 7 pandemic pandemic NN cord-048446-gaemgm0t 44 8 and and CC cord-048446-gaemgm0t 44 9 estimated estimate VBD cord-048446-gaemgm0t 44 10 some some DT cord-048446-gaemgm0t 44 11 of of IN cord-048446-gaemgm0t 44 12 these these DT cord-048446-gaemgm0t 44 13 key key JJ cord-048446-gaemgm0t 44 14 epidemiological epidemiological JJ cord-048446-gaemgm0t 44 15 parameters parameter NNS cord-048446-gaemgm0t 44 16 . . . cord-048446-gaemgm0t 45 1 Estimates estimate NNS cord-048446-gaemgm0t 45 2 have have VBP cord-048446-gaemgm0t 45 3 ranged range VBN cord-048446-gaemgm0t 45 4 from from IN cord-048446-gaemgm0t 45 5 2 2 CD cord-048446-gaemgm0t 45 6 - - SYM cord-048446-gaemgm0t 45 7 3 3 CD cord-048446-gaemgm0t 45 8 for for IN cord-048446-gaemgm0t 45 9 the the DT cord-048446-gaemgm0t 45 10 basic basic JJ cord-048446-gaemgm0t 45 11 reproductive reproductive JJ cord-048446-gaemgm0t 45 12 number number NN cord-048446-gaemgm0t 45 13 , , , cord-048446-gaemgm0t 45 14 R r NN cord-048446-gaemgm0t 45 15 0 0 CD cord-048446-gaemgm0t 45 16 , , , cord-048446-gaemgm0t 45 17 when when WRB cord-048446-gaemgm0t 45 18 using use VBG cord-048446-gaemgm0t 45 19 an an DT cord-048446-gaemgm0t 45 20 SEIR SEIR NNP cord-048446-gaemgm0t 45 21 model model NN cord-048446-gaemgm0t 45 22 with with IN cord-048446-gaemgm0t 45 23 a a DT cord-048446-gaemgm0t 45 24 mean mean JJ cord-048446-gaemgm0t 45 25 latent latent JJ cord-048446-gaemgm0t 45 26 period period NN cord-048446-gaemgm0t 45 27 of of IN cord-048446-gaemgm0t 45 28 1.9 1.9 CD cord-048446-gaemgm0t 45 29 days day NNS cord-048446-gaemgm0t 45 30 and and CC cord-048446-gaemgm0t 45 31 infectious infectious JJ cord-048446-gaemgm0t 45 32 period period NN cord-048446-gaemgm0t 45 33 of of IN cord-048446-gaemgm0t 45 34 4.1 4.1 CD cord-048446-gaemgm0t 45 35 days day NNS cord-048446-gaemgm0t 45 36 [ [ -LRB- cord-048446-gaemgm0t 45 37 13 13 CD cord-048446-gaemgm0t 45 38 , , , cord-048446-gaemgm0t 45 39 14 14 CD cord-048446-gaemgm0t 45 40 ] ] -RRB- cord-048446-gaemgm0t 45 41 . . . cord-048446-gaemgm0t 46 1 Using use VBG cord-048446-gaemgm0t 46 2 an an DT cord-048446-gaemgm0t 46 3 exponential exponential JJ cord-048446-gaemgm0t 46 4 model model NN cord-048446-gaemgm0t 46 5 and and CC cord-048446-gaemgm0t 46 6 assuming assume VBG cord-048446-gaemgm0t 46 7 the the DT cord-048446-gaemgm0t 46 8 serial serial JJ cord-048446-gaemgm0t 46 9 interval interval NN cord-048446-gaemgm0t 46 10 to to TO cord-048446-gaemgm0t 46 11 be be VB cord-048446-gaemgm0t 46 12 four four CD cord-048446-gaemgm0t 46 13 days day NNS cord-048446-gaemgm0t 46 14 ( ( -LRB- cord-048446-gaemgm0t 46 15 somewhat somewhat RB cord-048446-gaemgm0t 46 16 based base VBN cord-048446-gaemgm0t 46 17 on on IN cord-048446-gaemgm0t 46 18 the the DT cord-048446-gaemgm0t 46 19 assumptions assumption NNS cord-048446-gaemgm0t 46 20 of of IN cord-048446-gaemgm0t 46 21 [ [ -LRB- cord-048446-gaemgm0t 46 22 13 13 CD cord-048446-gaemgm0t 46 23 ] ] -RRB- cord-048446-gaemgm0t 46 24 ) ) -RRB- cord-048446-gaemgm0t 46 25 , , , cord-048446-gaemgm0t 46 26 [ [ -LRB- cord-048446-gaemgm0t 46 27 15 15 CD cord-048446-gaemgm0t 46 28 ] ] -RRB- cord-048446-gaemgm0t 46 29 estimated estimate VBN cord-048446-gaemgm0t 46 30 R r NN cord-048446-gaemgm0t 46 31 0 0 CD cord-048446-gaemgm0t 46 32 to to TO cord-048446-gaemgm0t 46 33 be be VB cord-048446-gaemgm0t 46 34 2.6 2.6 CD cord-048446-gaemgm0t 46 35 - - SYM cord-048446-gaemgm0t 46 36 10.6 10.6 CD cord-048446-gaemgm0t 46 37 for for IN cord-048446-gaemgm0t 46 38 confined confine VBN cord-048446-gaemgm0t 46 39 settings setting NNS cord-048446-gaemgm0t 46 40 ( ( -LRB- cord-048446-gaemgm0t 46 41 such such JJ cord-048446-gaemgm0t 46 42 as as IN cord-048446-gaemgm0t 46 43 prison prison NN cord-048446-gaemgm0t 46 44 and and CC cord-048446-gaemgm0t 46 45 ships ship NNS cord-048446-gaemgm0t 46 46 ) ) -RRB- cord-048446-gaemgm0t 46 47 and and CC cord-048446-gaemgm0t 46 48 2.4 2.4 CD cord-048446-gaemgm0t 46 49 - - SYM cord-048446-gaemgm0t 46 50 4.3 4.3 CD cord-048446-gaemgm0t 46 51 for for IN cord-048446-gaemgm0t 46 52 community community NN cord-048446-gaemgm0t 46 53 settings setting NNS cord-048446-gaemgm0t 46 54 . . . cord-048446-gaemgm0t 47 1 The the DT cord-048446-gaemgm0t 47 2 estimates estimate NNS cord-048446-gaemgm0t 47 3 for for IN cord-048446-gaemgm0t 47 4 the the DT cord-048446-gaemgm0t 47 5 mean mean JJ cord-048446-gaemgm0t 47 6 latent latent JJ cord-048446-gaemgm0t 47 7 and and CC cord-048446-gaemgm0t 47 8 infectious infectious JJ cord-048446-gaemgm0t 47 9 periods period NNS cord-048446-gaemgm0t 47 10 come come VBP cord-048446-gaemgm0t 47 11 from from IN cord-048446-gaemgm0t 47 12 [ [ -LRB- cord-048446-gaemgm0t 47 13 16 16 CD cord-048446-gaemgm0t 47 14 ] ] -RRB- cord-048446-gaemgm0t 47 15 and and CC cord-048446-gaemgm0t 47 16 were be VBD cord-048446-gaemgm0t 47 17 used use VBN cord-048446-gaemgm0t 47 18 again again RB cord-048446-gaemgm0t 47 19 by by IN cord-048446-gaemgm0t 47 20 [ [ -LRB- cord-048446-gaemgm0t 47 21 17 17 CD cord-048446-gaemgm0t 47 22 ] ] -RRB- cord-048446-gaemgm0t 47 23 and and CC cord-048446-gaemgm0t 47 24 [ [ -LRB- cord-048446-gaemgm0t 47 25 18 18 CD cord-048446-gaemgm0t 47 26 ] ] -RRB- cord-048446-gaemgm0t 47 27 . . . cord-048446-gaemgm0t 48 1 It -PRON- PRP cord-048446-gaemgm0t 48 2 appears appear VBZ cord-048446-gaemgm0t 48 3 that that IN cord-048446-gaemgm0t 48 4 the the DT cord-048446-gaemgm0t 48 5 original original JJ cord-048446-gaemgm0t 48 6 estimates estimate NNS cord-048446-gaemgm0t 48 7 were be VBD cord-048446-gaemgm0t 48 8 derived derive VBN cord-048446-gaemgm0t 48 9 from from IN cord-048446-gaemgm0t 48 10 epidemic epidemic NN cord-048446-gaemgm0t 48 11 data datum NNS cord-048446-gaemgm0t 48 12 , , , cord-048446-gaemgm0t 48 13 although although IN cord-048446-gaemgm0t 48 14 their -PRON- PRP$ cord-048446-gaemgm0t 48 15 source source NN cord-048446-gaemgm0t 48 16 is be VBZ cord-048446-gaemgm0t 48 17 not not RB cord-048446-gaemgm0t 48 18 well well RB cord-048446-gaemgm0t 48 19 documented document VBN cord-048446-gaemgm0t 48 20 . . . cord-048446-gaemgm0t 49 1 In in IN cord-048446-gaemgm0t 49 2 what what WP cord-048446-gaemgm0t 49 3 follows follow VBZ cord-048446-gaemgm0t 49 4 , , , cord-048446-gaemgm0t 49 5 we -PRON- PRP cord-048446-gaemgm0t 49 6 introduce introduce VBP cord-048446-gaemgm0t 49 7 new new JJ cord-048446-gaemgm0t 49 8 methodology methodology NN cord-048446-gaemgm0t 49 9 for for IN cord-048446-gaemgm0t 49 10 the the DT cord-048446-gaemgm0t 49 11 estimation estimation NN cord-048446-gaemgm0t 49 12 of of IN cord-048446-gaemgm0t 49 13 both both CC cord-048446-gaemgm0t 49 14 the the DT cord-048446-gaemgm0t 49 15 daily daily JJ cord-048446-gaemgm0t 49 16 reproductive reproductive JJ cord-048446-gaemgm0t 49 17 number number NN cord-048446-gaemgm0t 49 18 and and CC cord-048446-gaemgm0t 49 19 the the DT cord-048446-gaemgm0t 49 20 serial serial JJ cord-048446-gaemgm0t 49 21 interval interval NN cord-048446-gaemgm0t 49 22 . . . cord-048446-gaemgm0t 50 1 We -PRON- PRP cord-048446-gaemgm0t 50 2 apply apply VBP cord-048446-gaemgm0t 50 3 this this DT cord-048446-gaemgm0t 50 4 method method NN cord-048446-gaemgm0t 50 5 to to IN cord-048446-gaemgm0t 50 6 data datum NNS cord-048446-gaemgm0t 50 7 from from IN cord-048446-gaemgm0t 50 8 two two CD cord-048446-gaemgm0t 50 9 outbreaks outbreak NNS cord-048446-gaemgm0t 50 10 on on IN cord-048446-gaemgm0t 50 11 military military JJ cord-048446-gaemgm0t 50 12 ships ship NNS cord-048446-gaemgm0t 50 13 in in IN cord-048446-gaemgm0t 50 14 the the DT cord-048446-gaemgm0t 50 15 1918 1918 CD cord-048446-gaemgm0t 50 16 influenza influenza NN cord-048446-gaemgm0t 50 17 outbreak outbreak NN cord-048446-gaemgm0t 50 18 , , , cord-048446-gaemgm0t 50 19 as as RB cord-048446-gaemgm0t 50 20 well well RB cord-048446-gaemgm0t 50 21 as as IN cord-048446-gaemgm0t 50 22 welldocumented welldocumented JJ cord-048446-gaemgm0t 50 23 outbreaks outbreak NNS cord-048446-gaemgm0t 50 24 in in IN cord-048446-gaemgm0t 50 25 five five CD cord-048446-gaemgm0t 50 26 Maryland Maryland NNP cord-048446-gaemgm0t 50 27 communities community NNS cord-048446-gaemgm0t 50 28 . . . cord-048446-gaemgm0t 51 1 The the DT cord-048446-gaemgm0t 51 2 results result NNS cord-048446-gaemgm0t 51 3 from from IN cord-048446-gaemgm0t 51 4 this this DT cord-048446-gaemgm0t 51 5 method method NN cord-048446-gaemgm0t 51 6 are be VBP cord-048446-gaemgm0t 51 7 compared compare VBN cord-048446-gaemgm0t 51 8 to to IN cord-048446-gaemgm0t 51 9 that that DT cord-048446-gaemgm0t 51 10 of of IN cord-048446-gaemgm0t 51 11 [ [ -LRB- cord-048446-gaemgm0t 51 12 12 12 CD cord-048446-gaemgm0t 51 13 ] ] -RRB- cord-048446-gaemgm0t 51 14 . . . cord-048446-gaemgm0t 52 1 The the DT cord-048446-gaemgm0t 52 2 results result NNS cord-048446-gaemgm0t 52 3 illustrate illustrate VBP cord-048446-gaemgm0t 52 4 the the DT cord-048446-gaemgm0t 52 5 differences difference NNS cord-048446-gaemgm0t 52 6 in in IN cord-048446-gaemgm0t 52 7 infectious infectious JJ cord-048446-gaemgm0t 52 8 disease disease NN cord-048446-gaemgm0t 52 9 dynamics dynamic NNS cord-048446-gaemgm0t 52 10 between between IN cord-048446-gaemgm0t 52 11 outbreaks outbreak NNS cord-048446-gaemgm0t 52 12 in in IN cord-048446-gaemgm0t 52 13 a a DT cord-048446-gaemgm0t 52 14 closed closed JJ cord-048446-gaemgm0t 52 15 population population NN cord-048446-gaemgm0t 52 16 and and CC cord-048446-gaemgm0t 52 17 a a DT cord-048446-gaemgm0t 52 18 dynamic dynamic JJ cord-048446-gaemgm0t 52 19 community community NN cord-048446-gaemgm0t 52 20 . . . cord-048446-gaemgm0t 53 1 We -PRON- PRP cord-048446-gaemgm0t 53 2 analyze analyze VBP cord-048446-gaemgm0t 53 3 data datum NNS cord-048446-gaemgm0t 53 4 from from IN cord-048446-gaemgm0t 53 5 several several JJ cord-048446-gaemgm0t 53 6 well well RB cord-048446-gaemgm0t 53 7 - - HYPH cord-048446-gaemgm0t 53 8 documented document VBN cord-048446-gaemgm0t 53 9 influenza influenza NN cord-048446-gaemgm0t 53 10 outbreaks outbreak NNS cord-048446-gaemgm0t 53 11 in in IN cord-048446-gaemgm0t 53 12 1918 1918 CD cord-048446-gaemgm0t 53 13 . . . cord-048446-gaemgm0t 54 1 First first RB cord-048446-gaemgm0t 54 2 we -PRON- PRP cord-048446-gaemgm0t 54 3 consider consider VBP cord-048446-gaemgm0t 54 4 data datum NNS cord-048446-gaemgm0t 54 5 from from IN cord-048446-gaemgm0t 54 6 two two CD cord-048446-gaemgm0t 54 7 troop troop NN cord-048446-gaemgm0t 54 8 ships ship NNS cord-048446-gaemgm0t 54 9 that that WDT cord-048446-gaemgm0t 54 10 embarked embark VBD cord-048446-gaemgm0t 54 11 in in IN cord-048446-gaemgm0t 54 12 the the DT cord-048446-gaemgm0t 54 13 late late JJ cord-048446-gaemgm0t 54 14 fall fall NN cord-048446-gaemgm0t 54 15 of of IN cord-048446-gaemgm0t 54 16 1918 1918 CD cord-048446-gaemgm0t 54 17 [ [ -LRB- cord-048446-gaemgm0t 54 18 19 19 CD cord-048446-gaemgm0t 54 19 ] ] -RRB- cord-048446-gaemgm0t 54 20 . . . cord-048446-gaemgm0t 55 1 The the DT cord-048446-gaemgm0t 55 2 Medic Medic NNP cord-048446-gaemgm0t 55 3 reported report VBD cord-048446-gaemgm0t 55 4 two two CD cord-048446-gaemgm0t 55 5 initial initial JJ cord-048446-gaemgm0t 55 6 cases case NNS cord-048446-gaemgm0t 55 7 on on IN cord-048446-gaemgm0t 55 8 November November NNP cord-048446-gaemgm0t 55 9 11 11 CD cord-048446-gaemgm0t 55 10 . . . cord-048446-gaemgm0t 56 1 Out out IN cord-048446-gaemgm0t 56 2 of of IN cord-048446-gaemgm0t 56 3 989 989 CD cord-048446-gaemgm0t 56 4 passengers passenger NNS cord-048446-gaemgm0t 56 5 ( ( -LRB- cord-048446-gaemgm0t 56 6 156 156 CD cord-048446-gaemgm0t 56 7 crew crew NN cord-048446-gaemgm0t 56 8 members member NNS cord-048446-gaemgm0t 56 9 , , , cord-048446-gaemgm0t 56 10 829 829 CD cord-048446-gaemgm0t 56 11 soldiers soldier NNS cord-048446-gaemgm0t 56 12 , , , cord-048446-gaemgm0t 56 13 4 4 CD cord-048446-gaemgm0t 56 14 civilians civilian NNS cord-048446-gaemgm0t 56 15 ) ) -RRB- cord-048446-gaemgm0t 56 16 313 313 CD cord-048446-gaemgm0t 56 17 became become VBD cord-048446-gaemgm0t 56 18 sick sick JJ cord-048446-gaemgm0t 56 19 with with IN cord-048446-gaemgm0t 56 20 influenza influenza NN cord-048446-gaemgm0t 56 21 over over IN cord-048446-gaemgm0t 56 22 a a DT cord-048446-gaemgm0t 56 23 40 40 CD cord-048446-gaemgm0t 56 24 day day NN cord-048446-gaemgm0t 56 25 period period NN cord-048446-gaemgm0t 56 26 ( ( -LRB- cord-048446-gaemgm0t 56 27 Attack Attack NNP cord-048446-gaemgm0t 56 28 Rate Rate NNP cord-048446-gaemgm0t 56 29 , , , cord-048446-gaemgm0t 56 30 AR AR NNP cord-048446-gaemgm0t 56 31 , , , cord-048446-gaemgm0t 56 32 = = SYM cord-048446-gaemgm0t 56 33 0.32 0.32 CD cord-048446-gaemgm0t 56 34 ) ) -RRB- cord-048446-gaemgm0t 56 35 , , , cord-048446-gaemgm0t 56 36 though though IN cord-048446-gaemgm0t 56 37 most most JJS cord-048446-gaemgm0t 56 38 of of IN cord-048446-gaemgm0t 56 39 the the DT cord-048446-gaemgm0t 56 40 cases case NNS cord-048446-gaemgm0t 56 41 occurred occur VBD cord-048446-gaemgm0t 56 42 within within IN cord-048446-gaemgm0t 56 43 the the DT cord-048446-gaemgm0t 56 44 first first JJ cord-048446-gaemgm0t 56 45 fourteen fourteen CD cord-048446-gaemgm0t 56 46 days day NNS cord-048446-gaemgm0t 56 47 . . . cord-048446-gaemgm0t 57 1 The the DT cord-048446-gaemgm0t 57 2 Boonah Boonah NNP cord-048446-gaemgm0t 57 3 left leave VBD cord-048446-gaemgm0t 57 4 Durban Durban NNP cord-048446-gaemgm0t 57 5 and and CC cord-048446-gaemgm0t 57 6 in in IN cord-048446-gaemgm0t 57 7 five five CD cord-048446-gaemgm0t 57 8 days day NNS cord-048446-gaemgm0t 57 9 , , , cord-048446-gaemgm0t 57 10 on on IN cord-048446-gaemgm0t 57 11 November November NNP cord-048446-gaemgm0t 57 12 29 29 CD cord-048446-gaemgm0t 57 13 , , , cord-048446-gaemgm0t 57 14 reported report VBD cord-048446-gaemgm0t 57 15 the the DT cord-048446-gaemgm0t 57 16 first first JJ cord-048446-gaemgm0t 57 17 three three CD cord-048446-gaemgm0t 57 18 definitive definitive JJ cord-048446-gaemgm0t 57 19 cases case NNS cord-048446-gaemgm0t 57 20 of of IN cord-048446-gaemgm0t 57 21 influenza influenza NN cord-048446-gaemgm0t 57 22 . . . cord-048446-gaemgm0t 58 1 Those those DT cord-048446-gaemgm0t 58 2 who who WP cord-048446-gaemgm0t 58 3 collected collect VBD cord-048446-gaemgm0t 58 4 the the DT cord-048446-gaemgm0t 58 5 data data NN cord-048446-gaemgm0t 58 6 note note NN cord-048446-gaemgm0t 58 7 that that IN cord-048446-gaemgm0t 58 8 there there EX cord-048446-gaemgm0t 58 9 were be VBD cord-048446-gaemgm0t 58 10 likely likely RB cord-048446-gaemgm0t 58 11 some some DT cord-048446-gaemgm0t 58 12 initial initial JJ cord-048446-gaemgm0t 58 13 cases case NNS cord-048446-gaemgm0t 58 14 that that WDT cord-048446-gaemgm0t 58 15 were be VBD cord-048446-gaemgm0t 58 16 not not RB cord-048446-gaemgm0t 58 17 identified identify VBN cord-048446-gaemgm0t 58 18 . . . cord-048446-gaemgm0t 59 1 Out out IN cord-048446-gaemgm0t 59 2 of of IN cord-048446-gaemgm0t 59 3 1095 1095 CD cord-048446-gaemgm0t 59 4 on on IN cord-048446-gaemgm0t 59 5 board board NN cord-048446-gaemgm0t 59 6 ( ( -LRB- cord-048446-gaemgm0t 59 7 164 164 CD cord-048446-gaemgm0t 59 8 crew crew NN cord-048446-gaemgm0t 59 9 members member NNS cord-048446-gaemgm0t 59 10 and and CC cord-048446-gaemgm0t 59 11 931 931 CD cord-048446-gaemgm0t 59 12 troops troop NNS cord-048446-gaemgm0t 59 13 ) ) -RRB- cord-048446-gaemgm0t 59 14 , , , cord-048446-gaemgm0t 59 15 470 470 CD cord-048446-gaemgm0t 59 16 cases case NNS cord-048446-gaemgm0t 59 17 were be VBD cord-048446-gaemgm0t 59 18 reported report VBN cord-048446-gaemgm0t 59 19 ( ( -LRB- cord-048446-gaemgm0t 59 20 AR AR NNP cord-048446-gaemgm0t 59 21 = = SYM cord-048446-gaemgm0t 59 22 0.43 0.43 CD cord-048446-gaemgm0t 59 23 ) ) -RRB- cord-048446-gaemgm0t 59 24 in in IN cord-048446-gaemgm0t 59 25 the the DT cord-048446-gaemgm0t 59 26 40 40 CD cord-048446-gaemgm0t 59 27 days day NNS cord-048446-gaemgm0t 59 28 of of IN cord-048446-gaemgm0t 59 29 the the DT cord-048446-gaemgm0t 59 30 epidemic epidemic NN cord-048446-gaemgm0t 59 31 . . . cord-048446-gaemgm0t 60 1 The the DT cord-048446-gaemgm0t 60 2 United United NNP cord-048446-gaemgm0t 60 3 States States NNP cord-048446-gaemgm0t 60 4 Public Public NNP cord-048446-gaemgm0t 60 5 Health Health NNP cord-048446-gaemgm0t 60 6 Service Service NNP cord-048446-gaemgm0t 60 7 created create VBD cord-048446-gaemgm0t 60 8 special special JJ cord-048446-gaemgm0t 60 9 surveys survey NNS cord-048446-gaemgm0t 60 10 of of IN cord-048446-gaemgm0t 60 11 18 18 CD cord-048446-gaemgm0t 60 12 localities locality NNS cord-048446-gaemgm0t 60 13 during during IN cord-048446-gaemgm0t 60 14 the the DT cord-048446-gaemgm0t 60 15 pandemic pandemic NN cord-048446-gaemgm0t 60 16 [ [ -LRB- cord-048446-gaemgm0t 60 17 20 20 CD cord-048446-gaemgm0t 60 18 ] ] -RRB- cord-048446-gaemgm0t 60 19 . . . cord-048446-gaemgm0t 61 1 Reported report VBN cord-048446-gaemgm0t 61 2 results result NNS cord-048446-gaemgm0t 61 3 from from IN cord-048446-gaemgm0t 61 4 six six CD cord-048446-gaemgm0t 61 5 communities community NNS cord-048446-gaemgm0t 61 6 in in IN cord-048446-gaemgm0t 61 7 Maryland Maryland NNP cord-048446-gaemgm0t 61 8 are be VBP cord-048446-gaemgm0t 61 9 derived derive VBN cord-048446-gaemgm0t 61 10 from from IN cord-048446-gaemgm0t 61 11 house house NN cord-048446-gaemgm0t 61 12 - - HYPH cord-048446-gaemgm0t 61 13 to to IN cord-048446-gaemgm0t 61 14 - - HYPH cord-048446-gaemgm0t 61 15 house house NN cord-048446-gaemgm0t 61 16 surveys survey NNS cord-048446-gaemgm0t 61 17 requesting request VBG cord-048446-gaemgm0t 61 18 the the DT cord-048446-gaemgm0t 61 19 date date NN cord-048446-gaemgm0t 61 20 of of IN cord-048446-gaemgm0t 61 21 onset onset NN cord-048446-gaemgm0t 61 22 of of IN cord-048446-gaemgm0t 61 23 influenza influenza NN cord-048446-gaemgm0t 61 24 for for IN cord-048446-gaemgm0t 61 25 all all DT cord-048446-gaemgm0t 61 26 infected infect VBN cord-048446-gaemgm0t 61 27 , , , cord-048446-gaemgm0t 61 28 and and CC cord-048446-gaemgm0t 61 29 the the DT cord-048446-gaemgm0t 61 30 sex sex NN cord-048446-gaemgm0t 61 31 and and CC cord-048446-gaemgm0t 61 32 age age NN cord-048446-gaemgm0t 61 33 of of IN cord-048446-gaemgm0t 61 34 each each DT cord-048446-gaemgm0t 61 35 case case NN cord-048446-gaemgm0t 61 36 of of IN cord-048446-gaemgm0t 61 37 pneumonia pneumonia NN cord-048446-gaemgm0t 61 38 and and CC cord-048446-gaemgm0t 61 39 influenza influenza NN cord-048446-gaemgm0t 61 40 . . . cord-048446-gaemgm0t 62 1 A a DT cord-048446-gaemgm0t 62 2 summary summary NN cord-048446-gaemgm0t 62 3 of of IN cord-048446-gaemgm0t 62 4 these these DT cord-048446-gaemgm0t 62 5 populations population NNS cord-048446-gaemgm0t 62 6 is be VBZ cord-048446-gaemgm0t 62 7 provided provide VBN cord-048446-gaemgm0t 62 8 in in IN cord-048446-gaemgm0t 62 9 Table Table NNP cord-048446-gaemgm0t 62 10 1 1 CD cord-048446-gaemgm0t 62 11 . . . cord-048446-gaemgm0t 63 1 We -PRON- PRP cord-048446-gaemgm0t 63 2 describe describe VBP cord-048446-gaemgm0t 63 3 a a DT cord-048446-gaemgm0t 63 4 likelihood likelihood NN cord-048446-gaemgm0t 63 5 based base VBN cord-048446-gaemgm0t 63 6 methodology methodology NN cord-048446-gaemgm0t 63 7 for for IN cord-048446-gaemgm0t 63 8 estimating estimate VBG cord-048446-gaemgm0t 63 9 the the DT cord-048446-gaemgm0t 63 10 reproductive reproductive JJ cord-048446-gaemgm0t 63 11 number number NN cord-048446-gaemgm0t 63 12 at at IN cord-048446-gaemgm0t 63 13 each each DT cord-048446-gaemgm0t 63 14 day day NN cord-048446-gaemgm0t 63 15 in in IN cord-048446-gaemgm0t 63 16 the the DT cord-048446-gaemgm0t 63 17 epidemic epidemic NN cord-048446-gaemgm0t 63 18 as as RB cord-048446-gaemgm0t 63 19 well well RB cord-048446-gaemgm0t 63 20 as as IN cord-048446-gaemgm0t 63 21 the the DT cord-048446-gaemgm0t 63 22 serial serial JJ cord-048446-gaemgm0t 63 23 interval interval NN cord-048446-gaemgm0t 63 24 . . . cord-048446-gaemgm0t 64 1 The the DT cord-048446-gaemgm0t 64 2 method method NN cord-048446-gaemgm0t 64 3 builds build VBZ cord-048446-gaemgm0t 64 4 on on IN cord-048446-gaemgm0t 64 5 that that DT cord-048446-gaemgm0t 64 6 described describe VBN cord-048446-gaemgm0t 64 7 by by IN cord-048446-gaemgm0t 64 8 [ [ -LRB- cord-048446-gaemgm0t 64 9 21 21 CD cord-048446-gaemgm0t 64 10 ] ] -RRB- cord-048446-gaemgm0t 64 11 . . . cord-048446-gaemgm0t 65 1 We -PRON- PRP cord-048446-gaemgm0t 65 2 assume assume VBP cord-048446-gaemgm0t 65 3 that that IN cord-048446-gaemgm0t 65 4 the the DT cord-048446-gaemgm0t 65 5 population population NN cord-048446-gaemgm0t 65 6 is be VBZ cord-048446-gaemgm0t 65 7 closed close VBN cord-048446-gaemgm0t 65 8 , , , cord-048446-gaemgm0t 65 9 that that IN cord-048446-gaemgm0t 65 10 all all DT cord-048446-gaemgm0t 65 11 cases case NNS cord-048446-gaemgm0t 65 12 are be VBP cord-048446-gaemgm0t 65 13 observed observe VBN cord-048446-gaemgm0t 65 14 , , , cord-048446-gaemgm0t 65 15 and and CC cord-048446-gaemgm0t 65 16 use use VB cord-048446-gaemgm0t 65 17 daily daily JJ cord-048446-gaemgm0t 65 18 case case NN cord-048446-gaemgm0t 65 19 counts count VBZ cord-048446-gaemgm0t 65 20 only only RB cord-048446-gaemgm0t 65 21 ( ( -LRB- cord-048446-gaemgm0t 65 22 i.e. i.e. FW cord-048446-gaemgm0t 65 23 number number NN cord-048446-gaemgm0t 65 24 of of IN cord-048446-gaemgm0t 65 25 new new JJ cord-048446-gaemgm0t 65 26 cases case NNS cord-048446-gaemgm0t 65 27 each each DT cord-048446-gaemgm0t 65 28 day day NN cord-048446-gaemgm0t 65 29 ) ) -RRB- cord-048446-gaemgm0t 65 30 . . . cord-048446-gaemgm0t 66 1 Let let VB cord-048446-gaemgm0t 66 2 N n NN cord-048446-gaemgm0t 66 3 = = NFP cord-048446-gaemgm0t 66 4 { { -LRB- cord-048446-gaemgm0t 66 5 N n CD cord-048446-gaemgm0t 66 6 0 0 CD cord-048446-gaemgm0t 66 7 , , , cord-048446-gaemgm0t 66 8 N n CD cord-048446-gaemgm0t 66 9 1 1 CD cord-048446-gaemgm0t 66 10 , , , cord-048446-gaemgm0t 66 11 N n CD cord-048446-gaemgm0t 66 12 2 2 CD cord-048446-gaemgm0t 66 13 , , , cord-048446-gaemgm0t 66 14 … … NFP cord-048446-gaemgm0t 66 15 , , , cord-048446-gaemgm0t 66 16 N N NNP cord-048446-gaemgm0t 66 17 T t NN cord-048446-gaemgm0t 66 18 } } -RRB- cord-048446-gaemgm0t 66 19 represent represent VBP cord-048446-gaemgm0t 66 20 the the DT cord-048446-gaemgm0t 66 21 daily daily JJ cord-048446-gaemgm0t 66 22 cases case NNS cord-048446-gaemgm0t 66 23 counts count NNS cord-048446-gaemgm0t 66 24 of of IN cord-048446-gaemgm0t 66 25 influenza influenza NN cord-048446-gaemgm0t 66 26 for for IN cord-048446-gaemgm0t 66 27 the the DT cord-048446-gaemgm0t 66 28 T T NNP cord-048446-gaemgm0t 66 29 days day NNS cord-048446-gaemgm0t 66 30 of of IN cord-048446-gaemgm0t 66 31 the the DT cord-048446-gaemgm0t 66 32 epidemic epidemic NN cord-048446-gaemgm0t 66 33 and and CC cord-048446-gaemgm0t 66 34 X x NN cord-048446-gaemgm0t 66 35 ij ij NNP cord-048446-gaemgm0t 66 36 represent represent VBP cord-048446-gaemgm0t 66 37 the the DT cord-048446-gaemgm0t 66 38 number number NN cord-048446-gaemgm0t 66 39 of of IN cord-048446-gaemgm0t 66 40 cases case NNS cord-048446-gaemgm0t 66 41 that that WDT cord-048446-gaemgm0t 66 42 appear appear VBP cord-048446-gaemgm0t 66 43 on on IN cord-048446-gaemgm0t 66 44 day day NN cord-048446-gaemgm0t 66 45 j j NNP cord-048446-gaemgm0t 66 46 that that WDT cord-048446-gaemgm0t 66 47 are be VBP cord-048446-gaemgm0t 66 48 infected infect VBN cord-048446-gaemgm0t 66 49 by by IN cord-048446-gaemgm0t 66 50 individuals individual NNS cord-048446-gaemgm0t 66 51 that that WDT cord-048446-gaemgm0t 66 52 appeared appear VBD cord-048446-gaemgm0t 66 53 sick sick JJ cord-048446-gaemgm0t 66 54 on on IN cord-048446-gaemgm0t 66 55 day day NN cord-048446-gaemgm0t 67 1 i. i. LS cord-048446-gaemgm0t 67 2 Following following NN cord-048446-gaemgm0t 67 3 is be VBZ cord-048446-gaemgm0t 67 4 a a DT cord-048446-gaemgm0t 67 5 representation representation NN cord-048446-gaemgm0t 67 6 of of IN cord-048446-gaemgm0t 67 7 the the DT cord-048446-gaemgm0t 67 8 disease disease NN cord-048446-gaemgm0t 67 9 transmission transmission NN cord-048446-gaemgm0t 67 10 model model NN cord-048446-gaemgm0t 67 11 in in IN cord-048446-gaemgm0t 67 12 the the DT cord-048446-gaemgm0t 67 13 population population NN cord-048446-gaemgm0t 67 14 . . . cord-048446-gaemgm0t 67 15 . . . cord-048446-gaemgm0t 67 16 . . . cord-048446-gaemgm0t 68 1 We -PRON- PRP cord-048446-gaemgm0t 68 2 assume assume VBP cord-048446-gaemgm0t 68 3 that that IN cord-048446-gaemgm0t 68 4 the the DT cord-048446-gaemgm0t 68 5 total total JJ cord-048446-gaemgm0t 68 6 number number NN cord-048446-gaemgm0t 68 7 of of IN cord-048446-gaemgm0t 68 8 cases case NNS cord-048446-gaemgm0t 68 9 produced produce VBN cord-048446-gaemgm0t 68 10 by by IN cord-048446-gaemgm0t 68 11 those those DT cord-048446-gaemgm0t 68 12 on on IN cord-048446-gaemgm0t 68 13 day day NN cord-048446-gaemgm0t 68 14 i i PRP cord-048446-gaemgm0t 68 15 , , , cord-048446-gaemgm0t 68 16 X X NNP cord-048446-gaemgm0t 68 17 i i NNP cord-048446-gaemgm0t 68 18 ? ? . cord-048446-gaemgm0t 68 19 , , , cord-048446-gaemgm0t 68 20 are be VBP cord-048446-gaemgm0t 68 21 Poisson Poisson NNP cord-048446-gaemgm0t 68 22 distributed distribute VBN cord-048446-gaemgm0t 68 23 with with IN cord-048446-gaemgm0t 68 24 parameter parameter NN cord-048446-gaemgm0t 68 25 N n NN cord-048446-gaemgm0t 68 26 i i NN cord-048446-gaemgm0t 68 27 R r NN cord-048446-gaemgm0t 68 28 i i PRP cord-048446-gaemgm0t 68 29 , , , cord-048446-gaemgm0t 68 30 where where WRB cord-048446-gaemgm0t 68 31 R r NN cord-048446-gaemgm0t 68 32 i i PRP cord-048446-gaemgm0t 68 33 is be VBZ cord-048446-gaemgm0t 68 34 the the DT cord-048446-gaemgm0t 68 35 reproductive reproductive JJ cord-048446-gaemgm0t 68 36 number number NN cord-048446-gaemgm0t 68 37 for for IN cord-048446-gaemgm0t 68 38 cases case NNS cord-048446-gaemgm0t 68 39 on on IN cord-048446-gaemgm0t 68 40 day day NN cord-048446-gaemgm0t 69 1 i. i. NNP cord-048446-gaemgm0t 70 1 We -PRON- PRP cord-048446-gaemgm0t 70 2 further further RB cord-048446-gaemgm0t 70 3 assume assume VBP cord-048446-gaemgm0t 70 4 that that IN cord-048446-gaemgm0t 70 5 X x NN cord-048446-gaemgm0t 70 6 i i NN cord-048446-gaemgm0t 70 7 = = NN cord-048446-gaemgm0t 70 8 { { -LRB- cord-048446-gaemgm0t 70 9 X x NN cord-048446-gaemgm0t 70 10 i i NNP cord-048446-gaemgm0t 70 11 , , , cord-048446-gaemgm0t 70 12 i+1 i+1 NN cord-048446-gaemgm0t 70 13 , , , cord-048446-gaemgm0t 70 14 X X NNP cord-048446-gaemgm0t 70 15 i i NNP cord-048446-gaemgm0t 70 16 , , , cord-048446-gaemgm0t 70 17 i+2 i+2 NN cord-048446-gaemgm0t 70 18 , , , cord-048446-gaemgm0t 70 19 … … NFP cord-048446-gaemgm0t 70 20 , , , cord-048446-gaemgm0t 70 21 X X NNP cord-048446-gaemgm0t 70 22 i i NN cord-048446-gaemgm0t 70 23 , , , cord-048446-gaemgm0t 70 24 i+k i+k JJ cord-048446-gaemgm0t 70 25 } } -RRB- cord-048446-gaemgm0t 70 26 follows follow VBZ cord-048446-gaemgm0t 70 27 a a DT cord-048446-gaemgm0t 70 28 multinomial multinomial JJ cord-048446-gaemgm0t 70 29 distribution distribution NN cord-048446-gaemgm0t 70 30 with with IN cord-048446-gaemgm0t 70 31 parameters parameter NNS cord-048446-gaemgm0t 70 32 X X NNP cord-048446-gaemgm0t 70 33 i i NNP cord-048446-gaemgm0t 70 34 ? ? . cord-048446-gaemgm0t 70 35 , , , cord-048446-gaemgm0t 70 36 p p NN cord-048446-gaemgm0t 70 37 , , , cord-048446-gaemgm0t 70 38 k k NNP cord-048446-gaemgm0t 70 39 , , , cord-048446-gaemgm0t 70 40 where where WRB cord-048446-gaemgm0t 70 41 p p NN cord-048446-gaemgm0t 70 42 = = SYM cord-048446-gaemgm0t 70 43 { { -LRB- cord-048446-gaemgm0t 70 44 p p NN cord-048446-gaemgm0t 70 45 1 1 CD cord-048446-gaemgm0t 70 46 , , , cord-048446-gaemgm0t 70 47 p p NN cord-048446-gaemgm0t 70 48 2 2 CD cord-048446-gaemgm0t 70 49 , , , cord-048446-gaemgm0t 70 50 … … NFP cord-048446-gaemgm0t 70 51 , , , cord-048446-gaemgm0t 70 52 p p NN cord-048446-gaemgm0t 70 53 k k NN cord-048446-gaemgm0t 70 54 } } -RRB- cord-048446-gaemgm0t 70 55 represent represent VBP cord-048446-gaemgm0t 70 56 the the DT cord-048446-gaemgm0t 70 57 distribution distribution NN cord-048446-gaemgm0t 70 58 of of IN cord-048446-gaemgm0t 70 59 the the DT cord-048446-gaemgm0t 70 60 serial serial JJ cord-048446-gaemgm0t 70 61 interval interval NN cord-048446-gaemgm0t 70 62 . . . cord-048446-gaemgm0t 71 1 Using use VBG cord-048446-gaemgm0t 71 2 these these DT cord-048446-gaemgm0t 71 3 assumptions assumption NNS cord-048446-gaemgm0t 71 4 we -PRON- PRP cord-048446-gaemgm0t 71 5 can can MD cord-048446-gaemgm0t 71 6 construct construct VB cord-048446-gaemgm0t 71 7 a a DT cord-048446-gaemgm0t 71 8 likelihood likelihood NN cord-048446-gaemgm0t 71 9 function function NN cord-048446-gaemgm0t 71 10 ( ( -LRB- cord-048446-gaemgm0t 71 11 see see VB cord-048446-gaemgm0t 71 12 details detail NNS cord-048446-gaemgm0t 71 13 in in IN cord-048446-gaemgm0t 71 14 the the DT cord-048446-gaemgm0t 71 15 Supplemental Supplemental NNP cord-048446-gaemgm0t 71 16 Information Information NNP cord-048446-gaemgm0t 71 17 ) ) -RRB- cord-048446-gaemgm0t 71 18 , , , cord-048446-gaemgm0t 71 19 which which WDT cord-048446-gaemgm0t 71 20 , , , cord-048446-gaemgm0t 71 21 when when WRB cord-048446-gaemgm0t 71 22 simplified simplify VBN cord-048446-gaemgm0t 71 23 , , , cord-048446-gaemgm0t 71 24 yields yield VBZ cord-048446-gaemgm0t 71 25 the the DT cord-048446-gaemgm0t 71 26 following follow VBG cord-048446-gaemgm0t 71 27 convenient convenient JJ cord-048446-gaemgm0t 71 28 form form NN cord-048446-gaemgm0t 71 29 where where WRB cord-048446-gaemgm0t 71 30 m m NNP cord-048446-gaemgm0t 71 31 i i NN cord-048446-gaemgm0t 71 32 ~ ~ NFP cord-048446-gaemgm0t 71 33 Ri Ri NNP cord-048446-gaemgm0t 71 34 ( ( -LRB- cord-048446-gaemgm0t 72 1 X X NNP cord-048446-gaemgm0t 72 2 k k NNP cord-048446-gaemgm0t 72 3 j~1 j~1 NNP cord-048446-gaemgm0t 72 4 p p NN cord-048446-gaemgm0t 72 5 j j NNP cord-048446-gaemgm0t 73 1 N N NNP cord-048446-gaemgm0t 74 1 i{j i{j LS cord-048446-gaemgm0t 74 2 ) ) -RRB- cord-048446-gaemgm0t 74 3 [ [ -LRB- cord-048446-gaemgm0t 74 4 21 21 CD cord-048446-gaemgm0t 74 5 ] ] -RRB- cord-048446-gaemgm0t 74 6 . . . cord-048446-gaemgm0t 75 1 Maximization maximization NN cord-048446-gaemgm0t 75 2 of of IN cord-048446-gaemgm0t 75 3 this this DT cord-048446-gaemgm0t 75 4 likelihood likelihood NN cord-048446-gaemgm0t 75 5 with with IN cord-048446-gaemgm0t 75 6 respect respect NN cord-048446-gaemgm0t 75 7 to to IN cord-048446-gaemgm0t 75 8 R r NN cord-048446-gaemgm0t 75 9 i i NN cord-048446-gaemgm0t 75 10 and and CC cord-048446-gaemgm0t 75 11 p p NN cord-048446-gaemgm0t 75 12 yields yield NNS cord-048446-gaemgm0t 75 13 estimates estimate NNS cord-048446-gaemgm0t 75 14 of of IN cord-048446-gaemgm0t 75 15 these these DT cord-048446-gaemgm0t 75 16 parameters parameter NNS cord-048446-gaemgm0t 75 17 . . . cord-048446-gaemgm0t 76 1 To to TO cord-048446-gaemgm0t 76 2 further further RB cord-048446-gaemgm0t 76 3 simplify simplify VB cord-048446-gaemgm0t 76 4 this this DT cord-048446-gaemgm0t 76 5 process process NN cord-048446-gaemgm0t 76 6 and and CC cord-048446-gaemgm0t 76 7 create create VB cord-048446-gaemgm0t 76 8 a a DT cord-048446-gaemgm0t 76 9 more more RBR cord-048446-gaemgm0t 76 10 parsimonious parsimonious JJ cord-048446-gaemgm0t 76 11 model model NN cord-048446-gaemgm0t 76 12 , , , cord-048446-gaemgm0t 76 13 we -PRON- PRP cord-048446-gaemgm0t 76 14 parameterize parameterize VBP cord-048446-gaemgm0t 76 15 p p NN cord-048446-gaemgm0t 76 16 by by IN cord-048446-gaemgm0t 76 17 allowing allow VBG cord-048446-gaemgm0t 76 18 it -PRON- PRP cord-048446-gaemgm0t 76 19 to to TO cord-048446-gaemgm0t 76 20 follow follow VB cord-048446-gaemgm0t 76 21 a a DT cord-048446-gaemgm0t 76 22 traditional traditional JJ cord-048446-gaemgm0t 76 23 parametric parametric JJ cord-048446-gaemgm0t 76 24 form form NN cord-048446-gaemgm0t 76 25 for for IN cord-048446-gaemgm0t 76 26 a a DT cord-048446-gaemgm0t 76 27 serial serial JJ cord-048446-gaemgm0t 76 28 interval interval NN cord-048446-gaemgm0t 76 29 ( ( -LRB- cord-048446-gaemgm0t 76 30 for for IN cord-048446-gaemgm0t 76 31 instance instance NN cord-048446-gaemgm0t 76 32 a a DT cord-048446-gaemgm0t 76 33 Weibull Weibull NNP cord-048446-gaemgm0t 76 34 , , , cord-048446-gaemgm0t 76 35 Gamma Gamma NNP cord-048446-gaemgm0t 76 36 , , , cord-048446-gaemgm0t 76 37 Log Log NNP cord-048446-gaemgm0t 76 38 Normal Normal NNP cord-048446-gaemgm0t 76 39 , , , cord-048446-gaemgm0t 76 40 or or CC cord-048446-gaemgm0t 76 41 Exponential exponential JJ cord-048446-gaemgm0t 76 42 distribution distribution NN cord-048446-gaemgm0t 76 43 ) ) -RRB- cord-048446-gaemgm0t 76 44 . . . cord-048446-gaemgm0t 77 1 Then then RB cord-048446-gaemgm0t 77 2 the the DT cord-048446-gaemgm0t 77 3 p p NN cord-048446-gaemgm0t 77 4 j j NNP cord-048446-gaemgm0t 77 5 are be VBP cord-048446-gaemgm0t 77 6 functions function NNS cord-048446-gaemgm0t 77 7 of of IN cord-048446-gaemgm0t 77 8 the the DT cord-048446-gaemgm0t 77 9 parameters parameter NNS cord-048446-gaemgm0t 77 10 of of IN cord-048446-gaemgm0t 77 11 the the DT cord-048446-gaemgm0t 77 12 density density NN cord-048446-gaemgm0t 77 13 ( ( -LRB- cord-048446-gaemgm0t 77 14 for for IN cord-048446-gaemgm0t 77 15 instance instance NN cord-048446-gaemgm0t 77 16 in in IN cord-048446-gaemgm0t 77 17 the the DT cord-048446-gaemgm0t 77 18 case case NN cord-048446-gaemgm0t 77 19 of of IN cord-048446-gaemgm0t 77 20 the the DT cord-048446-gaemgm0t 77 21 Gamma Gamma NNP cord-048446-gaemgm0t 77 22 distribution distribution NN cord-048446-gaemgm0t 77 23 , , , cord-048446-gaemgm0t 77 24 the the DT cord-048446-gaemgm0t 77 25 p p NNP cord-048446-gaemgm0t 77 26 j j NNP cord-048446-gaemgm0t 77 27 only only RB cord-048446-gaemgm0t 77 28 depend depend VB cord-048446-gaemgm0t 77 29 on on IN cord-048446-gaemgm0t 77 30 the the DT cord-048446-gaemgm0t 77 31 shape shape NN cord-048446-gaemgm0t 77 32 and and CC cord-048446-gaemgm0t 77 33 rate rate NN cord-048446-gaemgm0t 77 34 parameters parameter NNS cord-048446-gaemgm0t 77 35 of of IN cord-048446-gaemgm0t 77 36 the the DT cord-048446-gaemgm0t 77 37 Gamma Gamma NNP cord-048446-gaemgm0t 77 38 ) ) -RRB- cord-048446-gaemgm0t 77 39 . . . cord-048446-gaemgm0t 78 1 Similarly similarly RB cord-048446-gaemgm0t 78 2 R r NN cord-048446-gaemgm0t 79 1 i i PRP cord-048446-gaemgm0t 79 2 can can MD cord-048446-gaemgm0t 79 3 be be VB cord-048446-gaemgm0t 79 4 modeled model VBN cord-048446-gaemgm0t 79 5 parametrically parametrically RB cord-048446-gaemgm0t 79 6 as as IN cord-048446-gaemgm0t 79 7 a a DT cord-048446-gaemgm0t 79 8 function function NN cord-048446-gaemgm0t 79 9 of of IN cord-048446-gaemgm0t 79 10 time time NN cord-048446-gaemgm0t 79 11 . . . cord-048446-gaemgm0t 80 1 One one CD cord-048446-gaemgm0t 80 2 example example NN cord-048446-gaemgm0t 80 3 of of IN cord-048446-gaemgm0t 80 4 a a DT cord-048446-gaemgm0t 80 5 reasonable reasonable JJ cord-048446-gaemgm0t 80 6 model model NN cord-048446-gaemgm0t 80 7 for for IN cord-048446-gaemgm0t 80 8 this this DT cord-048446-gaemgm0t 80 9 is be VBZ cord-048446-gaemgm0t 80 10 the the DT cord-048446-gaemgm0t 80 11 four four CD cord-048446-gaemgm0t 80 12 parameter parameter NN cord-048446-gaemgm0t 80 13 logistic logistic JJ cord-048446-gaemgm0t 80 14 curve curve NN cord-048446-gaemgm0t 80 15 [ [ -LRB- cord-048446-gaemgm0t 80 16 22 22 CD cord-048446-gaemgm0t 80 17 ] ] -RRB- cord-048446-gaemgm0t 80 18 [ [ -LRB- cord-048446-gaemgm0t 80 19 23 23 CD cord-048446-gaemgm0t 80 20 ] ] -RRB- cord-048446-gaemgm0t 80 21 [ [ -LRB- cord-048446-gaemgm0t 80 22 24 24 CD cord-048446-gaemgm0t 80 23 ] ] -RRB- cord-048446-gaemgm0t 80 24 given give VBN cord-048446-gaemgm0t 80 25 by by IN cord-048446-gaemgm0t 80 26 The the DT cord-048446-gaemgm0t 80 27 parameters parameter NNS cord-048446-gaemgm0t 80 28 of of IN cord-048446-gaemgm0t 80 29 this this DT cord-048446-gaemgm0t 80 30 curve curve NN cord-048446-gaemgm0t 80 31 describe describe VBP cord-048446-gaemgm0t 80 32 the the DT cord-048446-gaemgm0t 80 33 initial initial JJ cord-048446-gaemgm0t 80 34 height height NN cord-048446-gaemgm0t 80 35 of of IN cord-048446-gaemgm0t 80 36 the the DT cord-048446-gaemgm0t 80 37 curve curve NN cord-048446-gaemgm0t 80 38 ( ( -LRB- cord-048446-gaemgm0t 80 39 approximately approximately RB cord-048446-gaemgm0t 80 40 a+b a+b NNP cord-048446-gaemgm0t 80 41 ) ) -RRB- cord-048446-gaemgm0t 80 42 , , , cord-048446-gaemgm0t 80 43 the the DT cord-048446-gaemgm0t 80 44 point point NN cord-048446-gaemgm0t 80 45 of of IN cord-048446-gaemgm0t 80 46 inflection inflection NN cord-048446-gaemgm0t 80 47 ( ( -LRB- cord-048446-gaemgm0t 80 48 d d NNP cord-048446-gaemgm0t 80 49 ) ) -RRB- cord-048446-gaemgm0t 80 50 , , , cord-048446-gaemgm0t 80 51 the the DT cord-048446-gaemgm0t 80 52 curvature curvature NN cord-048446-gaemgm0t 80 53 over over IN cord-048446-gaemgm0t 80 54 the the DT cord-048446-gaemgm0t 80 55 inflection inflection NN cord-048446-gaemgm0t 80 56 ( ( -LRB- cord-048446-gaemgm0t 80 57 c c NN cord-048446-gaemgm0t 80 58 ) ) -RRB- cord-048446-gaemgm0t 80 59 and and CC cord-048446-gaemgm0t 80 60 the the DT cord-048446-gaemgm0t 80 61 final final JJ cord-048446-gaemgm0t 80 62 height height NN cord-048446-gaemgm0t 80 63 of of IN cord-048446-gaemgm0t 80 64 the the DT cord-048446-gaemgm0t 80 65 curve curve NN cord-048446-gaemgm0t 80 66 ( ( -LRB- cord-048446-gaemgm0t 80 67 a a NN cord-048446-gaemgm0t 80 68 ) ) -RRB- cord-048446-gaemgm0t 80 69 . . . cord-048446-gaemgm0t 81 1 These these DT cord-048446-gaemgm0t 81 2 parameters parameter NNS cord-048446-gaemgm0t 81 3 have have VBP cord-048446-gaemgm0t 81 4 biological biological JJ cord-048446-gaemgm0t 81 5 meaning meaning NN cord-048446-gaemgm0t 81 6 in in IN cord-048446-gaemgm0t 81 7 this this DT cord-048446-gaemgm0t 81 8 setting setting NN cord-048446-gaemgm0t 81 9 where where WRB cord-048446-gaemgm0t 81 10 the the DT cord-048446-gaemgm0t 81 11 initial initial JJ cord-048446-gaemgm0t 81 12 height height NN cord-048446-gaemgm0t 81 13 corresponds correspond VBZ cord-048446-gaemgm0t 81 14 to to IN cord-048446-gaemgm0t 81 15 the the DT cord-048446-gaemgm0t 81 16 values value NNS cord-048446-gaemgm0t 81 17 of of IN cord-048446-gaemgm0t 81 18 R r NN cord-048446-gaemgm0t 82 1 i i PRP cord-048446-gaemgm0t 82 2 prior prior RB cord-048446-gaemgm0t 82 3 to to IN cord-048446-gaemgm0t 82 4 intervention intervention NN cord-048446-gaemgm0t 82 5 and and CC cord-048446-gaemgm0t 82 6 significant significant JJ cord-048446-gaemgm0t 82 7 depletion depletion NN cord-048446-gaemgm0t 82 8 of of IN cord-048446-gaemgm0t 82 9 the the DT cord-048446-gaemgm0t 82 10 susceptible susceptible JJ cord-048446-gaemgm0t 82 11 population population NN cord-048446-gaemgm0t 82 12 . . . cord-048446-gaemgm0t 83 1 The the DT cord-048446-gaemgm0t 83 2 inflection inflection NN cord-048446-gaemgm0t 83 3 point point NN cord-048446-gaemgm0t 83 4 and and CC cord-048446-gaemgm0t 83 5 its -PRON- PRP$ cord-048446-gaemgm0t 83 6 steepness steepness NN cord-048446-gaemgm0t 83 7 would would MD cord-048446-gaemgm0t 83 8 describe describe VB cord-048446-gaemgm0t 83 9 the the DT cord-048446-gaemgm0t 83 10 timing timing NN cord-048446-gaemgm0t 83 11 of of IN cord-048446-gaemgm0t 83 12 intervention intervention NN cord-048446-gaemgm0t 83 13 and and CC cord-048446-gaemgm0t 83 14 the the DT cord-048446-gaemgm0t 83 15 rapidity rapidity NN cord-048446-gaemgm0t 83 16 with with IN cord-048446-gaemgm0t 83 17 which which WDT cord-048446-gaemgm0t 83 18 it -PRON- PRP cord-048446-gaemgm0t 83 19 impacts impact VBZ cord-048446-gaemgm0t 83 20 transmission transmission NN cord-048446-gaemgm0t 83 21 . . . cord-048446-gaemgm0t 84 1 The the DT cord-048446-gaemgm0t 84 2 final final JJ cord-048446-gaemgm0t 84 3 height height NN cord-048446-gaemgm0t 84 4 would would MD cord-048446-gaemgm0t 84 5 describe describe VB cord-048446-gaemgm0t 84 6 the the DT cord-048446-gaemgm0t 84 7 ultimate ultimate JJ cord-048446-gaemgm0t 84 8 value value NN cord-048446-gaemgm0t 84 9 of of IN cord-048446-gaemgm0t 84 10 R r NN cord-048446-gaemgm0t 84 11 i i NN cord-048446-gaemgm0t 84 12 , , , cord-048446-gaemgm0t 84 13 which which WDT cord-048446-gaemgm0t 84 14 typically typically RB cord-048446-gaemgm0t 84 15 is be VBZ cord-048446-gaemgm0t 84 16 less less JJR cord-048446-gaemgm0t 84 17 than than IN cord-048446-gaemgm0t 84 18 one one CD cord-048446-gaemgm0t 84 19 , , , cord-048446-gaemgm0t 84 20 indicating indicate VBG cord-048446-gaemgm0t 84 21 that that IN cord-048446-gaemgm0t 84 22 disease disease NN cord-048446-gaemgm0t 84 23 transmission transmission NN cord-048446-gaemgm0t 84 24 is be VBZ cord-048446-gaemgm0t 84 25 in in IN cord-048446-gaemgm0t 84 26 a a DT cord-048446-gaemgm0t 84 27 sub sub JJ cord-048446-gaemgm0t 84 28 epidemic epidemic NN cord-048446-gaemgm0t 84 29 state state NN cord-048446-gaemgm0t 84 30 . . . cord-048446-gaemgm0t 85 1 In in IN cord-048446-gaemgm0t 85 2 our -PRON- PRP$ cord-048446-gaemgm0t 85 3 analysis analysis NN cord-048446-gaemgm0t 85 4 , , , cord-048446-gaemgm0t 85 5 we -PRON- PRP cord-048446-gaemgm0t 85 6 also also RB cord-048446-gaemgm0t 85 7 implement implement VBP cord-048446-gaemgm0t 85 8 the the DT cord-048446-gaemgm0t 85 9 method method NN cord-048446-gaemgm0t 85 10 described describe VBN cord-048446-gaemgm0t 85 11 by by IN cord-048446-gaemgm0t 85 12 [ [ -LRB- cord-048446-gaemgm0t 85 13 12 12 CD cord-048446-gaemgm0t 85 14 ] ] -RRB- cord-048446-gaemgm0t 85 15 ( ( -LRB- cord-048446-gaemgm0t 85 16 hereafter hereafter RB cord-048446-gaemgm0t 85 17 referred refer VBD cord-048446-gaemgm0t 85 18 to to IN cord-048446-gaemgm0t 85 19 as as IN cord-048446-gaemgm0t 85 20 the the DT cord-048446-gaemgm0t 85 21 Garske Garske NNP cord-048446-gaemgm0t 85 22 et et FW cord-048446-gaemgm0t 85 23 al al NNP cord-048446-gaemgm0t 85 24 . . . cord-048446-gaemgm0t 85 25 method method NN cord-048446-gaemgm0t 85 26 ) ) -RRB- cord-048446-gaemgm0t 85 27 and and CC cord-048446-gaemgm0t 85 28 compare compare VB cord-048446-gaemgm0t 85 29 the the DT cord-048446-gaemgm0t 85 30 results result NNS cord-048446-gaemgm0t 85 31 of of IN cord-048446-gaemgm0t 85 32 the the DT cord-048446-gaemgm0t 85 33 two two CD cord-048446-gaemgm0t 85 34 methodologies methodology NNS cord-048446-gaemgm0t 85 35 . . . cord-048446-gaemgm0t 86 1 This this DT cord-048446-gaemgm0t 86 2 method method NN cord-048446-gaemgm0t 86 3 first first RB cord-048446-gaemgm0t 86 4 estimates estimate VBZ cord-048446-gaemgm0t 86 5 the the DT cord-048446-gaemgm0t 86 6 generation generation NN cord-048446-gaemgm0t 86 7 time time NN cord-048446-gaemgm0t 86 8 distribution distribution NN cord-048446-gaemgm0t 86 9 using use VBG cord-048446-gaemgm0t 86 10 a a DT cord-048446-gaemgm0t 86 11 likelihood likelihood NN cord-048446-gaemgm0t 86 12 based base VBN cord-048446-gaemgm0t 86 13 method method NN cord-048446-gaemgm0t 86 14 . . . cord-048446-gaemgm0t 87 1 Then then RB cord-048446-gaemgm0t 87 2 the the DT cord-048446-gaemgm0t 87 3 effective effective JJ cord-048446-gaemgm0t 87 4 reproductive reproductive JJ cord-048446-gaemgm0t 87 5 number number NN cord-048446-gaemgm0t 87 6 is be VBZ cord-048446-gaemgm0t 87 7 estimated estimate VBN cord-048446-gaemgm0t 87 8 using use VBG cord-048446-gaemgm0t 87 9 the the DT cord-048446-gaemgm0t 87 10 method method NN cord-048446-gaemgm0t 87 11 described describe VBN cord-048446-gaemgm0t 87 12 by by IN cord-048446-gaemgm0t 87 13 [ [ -LRB- cord-048446-gaemgm0t 87 14 7 7 CD cord-048446-gaemgm0t 87 15 ] ] -RRB- cord-048446-gaemgm0t 87 16 ( ( -LRB- cord-048446-gaemgm0t 87 17 hereafter hereafter RB cord-048446-gaemgm0t 87 18 referred refer VBN cord-048446-gaemgm0t 87 19 to to IN cord-048446-gaemgm0t 87 20 as as IN cord-048446-gaemgm0t 87 21 the the DT cord-048446-gaemgm0t 87 22 WT WT NNP cord-048446-gaemgm0t 87 23 method method NN cord-048446-gaemgm0t 87 24 ) ) -RRB- cord-048446-gaemgm0t 87 25 . . . cord-048446-gaemgm0t 88 1 We -PRON- PRP cord-048446-gaemgm0t 88 2 fit fit VBP cord-048446-gaemgm0t 88 3 the the DT cord-048446-gaemgm0t 88 4 likelihood likelihood NN cord-048446-gaemgm0t 88 5 for for IN cord-048446-gaemgm0t 88 6 both both DT cord-048446-gaemgm0t 88 7 methods method NNS cord-048446-gaemgm0t 88 8 using use VBG cord-048446-gaemgm0t 88 9 a a DT cord-048446-gaemgm0t 88 10 Nelder Nelder NNP cord-048446-gaemgm0t 88 11 - - HYPH cord-048446-gaemgm0t 88 12 Mead Mead NNP cord-048446-gaemgm0t 88 13 maximization maximization NN cord-048446-gaemgm0t 88 14 procedure procedure NN cord-048446-gaemgm0t 88 15 and and CC cord-048446-gaemgm0t 88 16 use use VB cord-048446-gaemgm0t 88 17 576 576 CD cord-048446-gaemgm0t 88 18 starting start VBG cord-048446-gaemgm0t 88 19 values value NNS cord-048446-gaemgm0t 88 20 in in IN cord-048446-gaemgm0t 88 21 order order NN cord-048446-gaemgm0t 88 22 to to TO cord-048446-gaemgm0t 88 23 ensure ensure VB cord-048446-gaemgm0t 88 24 that that IN cord-048446-gaemgm0t 88 25 we -PRON- PRP cord-048446-gaemgm0t 88 26 reach reach VBP cord-048446-gaemgm0t 88 27 the the DT cord-048446-gaemgm0t 88 28 global global JJ cord-048446-gaemgm0t 88 29 maximum maximum NN cord-048446-gaemgm0t 88 30 . . . cord-048446-gaemgm0t 89 1 All all DT cord-048446-gaemgm0t 89 2 analyses analysis NNS cord-048446-gaemgm0t 89 3 were be VBD cord-048446-gaemgm0t 89 4 done do VBN cord-048446-gaemgm0t 89 5 using use VBG cord-048446-gaemgm0t 89 6 R r NN cord-048446-gaemgm0t 89 7 2.4.1 2.4.1 NN cord-048446-gaemgm0t 89 8 . . . cord-048446-gaemgm0t 90 1 Both both DT cord-048446-gaemgm0t 90 2 methods method NNS cord-048446-gaemgm0t 90 3 assume assume VBP cord-048446-gaemgm0t 90 4 homogenous homogenous JJ cord-048446-gaemgm0t 90 5 mixing mixing NN cord-048446-gaemgm0t 90 6 in in IN cord-048446-gaemgm0t 90 7 the the DT cord-048446-gaemgm0t 90 8 population population NN cord-048446-gaemgm0t 90 9 , , , cord-048446-gaemgm0t 90 10 no no DT cord-048446-gaemgm0t 90 11 missing miss VBG cord-048446-gaemgm0t 90 12 data datum NNS cord-048446-gaemgm0t 90 13 ( ( -LRB- cord-048446-gaemgm0t 90 14 clearly clearly RB cord-048446-gaemgm0t 90 15 violated violate VBN cord-048446-gaemgm0t 90 16 with with IN cord-048446-gaemgm0t 90 17 the the DT cord-048446-gaemgm0t 90 18 data datum NNS cord-048446-gaemgm0t 90 19 from from IN cord-048446-gaemgm0t 90 20 the the DT cord-048446-gaemgm0t 90 21 Maryland Maryland NNP cord-048446-gaemgm0t 90 22 communities community NNS cord-048446-gaemgm0t 90 23 ) ) -RRB- cord-048446-gaemgm0t 90 24 , , , cord-048446-gaemgm0t 90 25 that that IN cord-048446-gaemgm0t 90 26 a a DT cord-048446-gaemgm0t 90 27 primary primary JJ cord-048446-gaemgm0t 90 28 case case NN cord-048446-gaemgm0t 90 29 experiences experience VBZ cord-048446-gaemgm0t 90 30 symptom symptom NN cord-048446-gaemgm0t 90 31 onset onset NN cord-048446-gaemgm0t 90 32 prior prior RB cord-048446-gaemgm0t 90 33 to to IN cord-048446-gaemgm0t 90 34 any any DT cord-048446-gaemgm0t 90 35 cases case NNS cord-048446-gaemgm0t 90 36 that that WDT cord-048446-gaemgm0t 90 37 it -PRON- PRP cord-048446-gaemgm0t 90 38 infects infect VBZ cord-048446-gaemgm0t 90 39 and and CC cord-048446-gaemgm0t 90 40 a a DT cord-048446-gaemgm0t 90 41 completely completely RB cord-048446-gaemgm0t 90 42 closed closed JJ cord-048446-gaemgm0t 90 43 system system NN cord-048446-gaemgm0t 90 44 where where WRB cord-048446-gaemgm0t 90 45 all all DT cord-048446-gaemgm0t 90 46 cases case NNS cord-048446-gaemgm0t 90 47 are be VBP cord-048446-gaemgm0t 90 48 infected infect VBN cord-048446-gaemgm0t 90 49 by by IN cord-048446-gaemgm0t 90 50 a a DT cord-048446-gaemgm0t 90 51 case case NN cord-048446-gaemgm0t 90 52 that that WDT cord-048446-gaemgm0t 90 53 has have VBZ cord-048446-gaemgm0t 90 54 been be VBN cord-048446-gaemgm0t 90 55 observed observe VBN cord-048446-gaemgm0t 90 56 . . . cord-048446-gaemgm0t 91 1 In in IN cord-048446-gaemgm0t 91 2 the the DT cord-048446-gaemgm0t 91 3 case case NN cord-048446-gaemgm0t 91 4 of of IN cord-048446-gaemgm0t 91 5 the the DT cord-048446-gaemgm0t 91 6 Maryland Maryland NNP cord-048446-gaemgm0t 91 7 data datum NNS cord-048446-gaemgm0t 91 8 , , , cord-048446-gaemgm0t 91 9 where where WRB cord-048446-gaemgm0t 91 10 only only RB cord-048446-gaemgm0t 91 11 a a DT cord-048446-gaemgm0t 91 12 sample sample NN cord-048446-gaemgm0t 91 13 of of IN cord-048446-gaemgm0t 91 14 the the DT cord-048446-gaemgm0t 91 15 total total JJ cord-048446-gaemgm0t 91 16 number number NN cord-048446-gaemgm0t 91 17 of of IN cord-048446-gaemgm0t 91 18 cases case NNS cord-048446-gaemgm0t 91 19 was be VBD cord-048446-gaemgm0t 91 20 surveyed survey VBN cord-048446-gaemgm0t 91 21 , , , cord-048446-gaemgm0t 91 22 we -PRON- PRP cord-048446-gaemgm0t 91 23 can can MD cord-048446-gaemgm0t 91 24 observe observe VB cord-048446-gaemgm0t 91 25 the the DT cord-048446-gaemgm0t 91 26 efficacy efficacy NN cord-048446-gaemgm0t 91 27 and and CC cord-048446-gaemgm0t 91 28 robustness robustness NN cord-048446-gaemgm0t 91 29 of of IN cord-048446-gaemgm0t 91 30 these these DT cord-048446-gaemgm0t 91 31 methods method NNS cord-048446-gaemgm0t 91 32 with with IN cord-048446-gaemgm0t 91 33 sample sample NN cord-048446-gaemgm0t 91 34 data datum NNS cord-048446-gaemgm0t 91 35 . . . cord-048446-gaemgm0t 92 1 Certainly certainly RB cord-048446-gaemgm0t 92 2 results result NNS cord-048446-gaemgm0t 92 3 should should MD cord-048446-gaemgm0t 92 4 be be VB cord-048446-gaemgm0t 92 5 interpreted interpret VBN cord-048446-gaemgm0t 92 6 with with IN cord-048446-gaemgm0t 92 7 caution caution NN cord-048446-gaemgm0t 92 8 , , , cord-048446-gaemgm0t 92 9 however however RB cord-048446-gaemgm0t 92 10 , , , cord-048446-gaemgm0t 92 11 as as IN cord-048446-gaemgm0t 92 12 we -PRON- PRP cord-048446-gaemgm0t 92 13 will will MD cord-048446-gaemgm0t 92 14 show show VB cord-048446-gaemgm0t 92 15 , , , cord-048446-gaemgm0t 92 16 the the DT cord-048446-gaemgm0t 92 17 results result NNS cord-048446-gaemgm0t 92 18 that that WDT cord-048446-gaemgm0t 92 19 are be VBP cord-048446-gaemgm0t 92 20 obtained obtain VBN cord-048446-gaemgm0t 92 21 are be VBP cord-048446-gaemgm0t 92 22 consistent consistent JJ cord-048446-gaemgm0t 92 23 with with IN cord-048446-gaemgm0t 92 24 previous previous JJ cord-048446-gaemgm0t 92 25 estimates estimate NNS cord-048446-gaemgm0t 92 26 for for IN cord-048446-gaemgm0t 92 27 influenza influenza NN cord-048446-gaemgm0t 92 28 . . . cord-048446-gaemgm0t 93 1 Standard standard JJ cord-048446-gaemgm0t 93 2 errors error NNS cord-048446-gaemgm0t 93 3 were be VBD cord-048446-gaemgm0t 93 4 calculated calculate VBN cord-048446-gaemgm0t 93 5 for for IN cord-048446-gaemgm0t 93 6 the the DT cord-048446-gaemgm0t 93 7 MLE MLE NNP cord-048446-gaemgm0t 93 8 method method NN cord-048446-gaemgm0t 93 9 using use VBG cord-048446-gaemgm0t 93 10 a a DT cord-048446-gaemgm0t 93 11 parametric parametric JJ cord-048446-gaemgm0t 93 12 bootstrap bootstrap NN cord-048446-gaemgm0t 93 13 . . . cord-048446-gaemgm0t 94 1 One one CD cord-048446-gaemgm0t 94 2 thousand thousand CD cord-048446-gaemgm0t 94 3 epidemics epidemic NNS cord-048446-gaemgm0t 94 4 were be VBD cord-048446-gaemgm0t 94 5 simulated simulate VBN cord-048446-gaemgm0t 94 6 using use VBG cord-048446-gaemgm0t 94 7 the the DT cord-048446-gaemgm0t 94 8 parameter parameter NN cord-048446-gaemgm0t 94 9 estimates estimate NNS cord-048446-gaemgm0t 94 10 and and CC cord-048446-gaemgm0t 94 11 estimates estimate NNS cord-048446-gaemgm0t 94 12 were be VBD cord-048446-gaemgm0t 94 13 obtained obtain VBN cord-048446-gaemgm0t 94 14 from from IN cord-048446-gaemgm0t 94 15 each each DT cord-048446-gaemgm0t 94 16 of of IN cord-048446-gaemgm0t 94 17 these these DT cord-048446-gaemgm0t 94 18 simulated simulate VBN cord-048446-gaemgm0t 94 19 epidemics epidemic NNS cord-048446-gaemgm0t 94 20 . . . cord-048446-gaemgm0t 95 1 The the DT cord-048446-gaemgm0t 95 2 standard standard JJ cord-048446-gaemgm0t 95 3 deviation deviation NN cord-048446-gaemgm0t 95 4 of of IN cord-048446-gaemgm0t 95 5 the the DT cord-048446-gaemgm0t 95 6 1000 1000 CD cord-048446-gaemgm0t 95 7 estimates estimate NNS cord-048446-gaemgm0t 95 8 was be VBD cord-048446-gaemgm0t 95 9 used use VBN cord-048446-gaemgm0t 95 10 as as IN cord-048446-gaemgm0t 95 11 the the DT cord-048446-gaemgm0t 95 12 standard standard JJ cord-048446-gaemgm0t 95 13 error error NN cord-048446-gaemgm0t 95 14 estimates estimate NNS cord-048446-gaemgm0t 95 15 . . . cord-048446-gaemgm0t 96 1 We -PRON- PRP cord-048446-gaemgm0t 96 2 used use VBD cord-048446-gaemgm0t 96 3 the the DT cord-048446-gaemgm0t 96 4 method method NN cord-048446-gaemgm0t 96 5 described describe VBN cord-048446-gaemgm0t 96 6 in in IN cord-048446-gaemgm0t 96 7 [ [ -LRB- cord-048446-gaemgm0t 96 8 12 12 CD cord-048446-gaemgm0t 96 9 ] ] -RRB- cord-048446-gaemgm0t 96 10 to to TO cord-048446-gaemgm0t 96 11 estimate estimate VB cord-048446-gaemgm0t 96 12 the the DT cord-048446-gaemgm0t 96 13 standard standard JJ cord-048446-gaemgm0t 96 14 error error NN cord-048446-gaemgm0t 96 15 for for IN cord-048446-gaemgm0t 96 16 their -PRON- PRP$ cord-048446-gaemgm0t 96 17 estimates estimate NNS cord-048446-gaemgm0t 96 18 , , , cord-048446-gaemgm0t 96 19 however however RB cord-048446-gaemgm0t 96 20 our -PRON- PRP$ cord-048446-gaemgm0t 96 21 simulations simulation NNS cord-048446-gaemgm0t 96 22 based base VBN cord-048446-gaemgm0t 96 23 on on IN cord-048446-gaemgm0t 96 24 their -PRON- PRP$ cord-048446-gaemgm0t 96 25 assumption assumption NN cord-048446-gaemgm0t 96 26 of of IN cord-048446-gaemgm0t 96 27 asymptotic asymptotic JJ cord-048446-gaemgm0t 96 28 normality normality NN cord-048446-gaemgm0t 96 29 yielded yield VBD cord-048446-gaemgm0t 96 30 a a DT cord-048446-gaemgm0t 96 31 large large JJ cord-048446-gaemgm0t 96 32 number number NN cord-048446-gaemgm0t 96 33 of of IN cord-048446-gaemgm0t 96 34 negative negative JJ cord-048446-gaemgm0t 96 35 estimates estimate NNS cord-048446-gaemgm0t 96 36 for for IN cord-048446-gaemgm0t 96 37 the the DT cord-048446-gaemgm0t 96 38 parameters parameter NNS cord-048446-gaemgm0t 96 39 . . . cord-048446-gaemgm0t 97 1 It -PRON- PRP cord-048446-gaemgm0t 97 2 is be VBZ cord-048446-gaemgm0t 97 3 possible possible JJ cord-048446-gaemgm0t 97 4 that that IN cord-048446-gaemgm0t 97 5 this this DT cord-048446-gaemgm0t 97 6 is be VBZ cord-048446-gaemgm0t 97 7 due due JJ cord-048446-gaemgm0t 97 8 to to IN cord-048446-gaemgm0t 97 9 the the DT cord-048446-gaemgm0t 97 10 non non JJ cord-048446-gaemgm0t 97 11 - - JJ cord-048446-gaemgm0t 97 12 independence independence NN cord-048446-gaemgm0t 97 13 in in IN cord-048446-gaemgm0t 97 14 the the DT cord-048446-gaemgm0t 97 15 data datum NNS cord-048446-gaemgm0t 97 16 and and CC cord-048446-gaemgm0t 97 17 lack lack NN cord-048446-gaemgm0t 97 18 of of IN cord-048446-gaemgm0t 97 19 theoretical theoretical JJ cord-048446-gaemgm0t 97 20 underpinnings underpinning NNS cord-048446-gaemgm0t 97 21 for for IN cord-048446-gaemgm0t 97 22 the the DT cord-048446-gaemgm0t 97 23 method method NN cord-048446-gaemgm0t 97 24 that that WDT cord-048446-gaemgm0t 97 25 they -PRON- PRP cord-048446-gaemgm0t 97 26 propose propose VBP cord-048446-gaemgm0t 97 27 . . . cord-048446-gaemgm0t 98 1 These these DT cord-048446-gaemgm0t 98 2 results result NNS cord-048446-gaemgm0t 98 3 make make VBP cord-048446-gaemgm0t 98 4 their -PRON- PRP$ cord-048446-gaemgm0t 98 5 standard standard JJ cord-048446-gaemgm0t 98 6 error error NN cord-048446-gaemgm0t 98 7 estimates estimate VBZ cord-048446-gaemgm0t 98 8 infeasible infeasible JJ cord-048446-gaemgm0t 98 9 to to TO cord-048446-gaemgm0t 98 10 estimate estimate VB cord-048446-gaemgm0t 98 11 in in IN cord-048446-gaemgm0t 98 12 this this DT cord-048446-gaemgm0t 98 13 case case NN cord-048446-gaemgm0t 98 14 . . . cord-048446-gaemgm0t 99 1 Therefore therefore RB cord-048446-gaemgm0t 99 2 we -PRON- PRP cord-048446-gaemgm0t 99 3 do do VBP cord-048446-gaemgm0t 99 4 not not RB cord-048446-gaemgm0t 99 5 present present VB cord-048446-gaemgm0t 99 6 standard standard JJ cord-048446-gaemgm0t 99 7 error error NN cord-048446-gaemgm0t 99 8 estimates estimate NNS cord-048446-gaemgm0t 99 9 for for IN cord-048446-gaemgm0t 99 10 the the DT cord-048446-gaemgm0t 99 11 results result NNS cord-048446-gaemgm0t 99 12 obtained obtain VBN cord-048446-gaemgm0t 99 13 using use VBG cord-048446-gaemgm0t 99 14 their -PRON- PRP$ cord-048446-gaemgm0t 99 15 methodology methodology NN cord-048446-gaemgm0t 99 16 . . . cord-048446-gaemgm0t 100 1 In in IN cord-048446-gaemgm0t 100 2 order order NN cord-048446-gaemgm0t 100 3 to to TO cord-048446-gaemgm0t 100 4 determine determine VB cord-048446-gaemgm0t 100 5 the the DT cord-048446-gaemgm0t 100 6 accuracy accuracy NN cord-048446-gaemgm0t 100 7 and and CC cord-048446-gaemgm0t 100 8 relative relative JJ cord-048446-gaemgm0t 100 9 merit merit NN cord-048446-gaemgm0t 100 10 of of IN cord-048446-gaemgm0t 100 11 the the DT cord-048446-gaemgm0t 100 12 estimates estimate NNS cord-048446-gaemgm0t 100 13 obtained obtain VBN cord-048446-gaemgm0t 100 14 from from IN cord-048446-gaemgm0t 100 15 each each DT cord-048446-gaemgm0t 100 16 methodology methodology NN cord-048446-gaemgm0t 100 17 , , , cord-048446-gaemgm0t 100 18 we -PRON- PRP cord-048446-gaemgm0t 100 19 compute compute VBP cord-048446-gaemgm0t 100 20 one one CD cord-048446-gaemgm0t 100 21 - - HYPH cord-048446-gaemgm0t 100 22 stepahead stepahead NN cord-048446-gaemgm0t 100 23 residuals residual NNS cord-048446-gaemgm0t 100 24 and and CC cord-048446-gaemgm0t 100 25 implement implement VB cord-048446-gaemgm0t 100 26 a a DT cord-048446-gaemgm0t 100 27 cross cross NN cord-048446-gaemgm0t 100 28 validation validation NN cord-048446-gaemgm0t 100 29 approach approach NN cord-048446-gaemgm0t 100 30 to to TO cord-048446-gaemgm0t 100 31 analyze analyze VB cord-048446-gaemgm0t 100 32 the the DT cord-048446-gaemgm0t 100 33 generalizeability generalizeability NN cord-048446-gaemgm0t 100 34 of of IN cord-048446-gaemgm0t 100 35 the the DT cord-048446-gaemgm0t 100 36 estimates estimate NNS cord-048446-gaemgm0t 100 37 obtained obtain VBN cord-048446-gaemgm0t 100 38 . . . cord-048446-gaemgm0t 101 1 The the DT cord-048446-gaemgm0t 101 2 onestep onestep NN cord-048446-gaemgm0t 101 3 - - HYPH cord-048446-gaemgm0t 101 4 ahead ahead JJ cord-048446-gaemgm0t 101 5 residuals residual NNS cord-048446-gaemgm0t 101 6 were be VBD cord-048446-gaemgm0t 101 7 calculated calculate VBN cord-048446-gaemgm0t 101 8 by by IN cord-048446-gaemgm0t 101 9 first first RB cord-048446-gaemgm0t 101 10 using use VBG cord-048446-gaemgm0t 101 11 the the DT cord-048446-gaemgm0t 101 12 estimates estimate NNS cord-048446-gaemgm0t 101 13 from from IN cord-048446-gaemgm0t 101 14 a a DT cord-048446-gaemgm0t 101 15 particular particular JJ cord-048446-gaemgm0t 101 16 location location NN cord-048446-gaemgm0t 101 17 along along IN cord-048446-gaemgm0t 101 18 with with IN cord-048446-gaemgm0t 101 19 the the DT cord-048446-gaemgm0t 101 20 data datum NNS cord-048446-gaemgm0t 101 21 to to TO cord-048446-gaemgm0t 101 22 predict predict VB cord-048446-gaemgm0t 101 23 the the DT cord-048446-gaemgm0t 101 24 next next JJ cord-048446-gaemgm0t 101 25 days day NNS cord-048446-gaemgm0t 101 26 ' ' POS cord-048446-gaemgm0t 101 27 number number NN cord-048446-gaemgm0t 101 28 of of IN cord-048446-gaemgm0t 101 29 cases case NNS cord-048446-gaemgm0t 101 30 , , , cord-048446-gaemgm0t 101 31 Ñ ñ UH cord-048446-gaemgm0t 101 32 i i PRP cord-048446-gaemgm0t 101 33 as as IN cord-048446-gaemgm0t 101 34 follows follow VBZ cord-048446-gaemgm0t 101 35 : : : cord-048446-gaemgm0t 102 1 EachÑ EachÑ NNP cord-048446-gaemgm0t 103 1 i i PRP cord-048446-gaemgm0t 103 2 is be VBZ cord-048446-gaemgm0t 103 3 calculated calculate VBN cord-048446-gaemgm0t 103 4 using use VBG cord-048446-gaemgm0t 103 5 N n CD cord-048446-gaemgm0t 103 6 0 0 CD cord-048446-gaemgm0t 103 7 , , , cord-048446-gaemgm0t 103 8 N n CD cord-048446-gaemgm0t 103 9 1 1 CD cord-048446-gaemgm0t 103 10 , , , cord-048446-gaemgm0t 103 11 … … NFP cord-048446-gaemgm0t 103 12 , , , cord-048446-gaemgm0t 103 13 N n CD cord-048446-gaemgm0t 103 14 i21 i21 NN cord-048446-gaemgm0t 103 15 . . . cord-048446-gaemgm0t 104 1 Then then RB cord-048446-gaemgm0t 104 2 the the DT cord-048446-gaemgm0t 104 3 one one CD cord-048446-gaemgm0t 104 4 - - HYPH cord-048446-gaemgm0t 104 5 stepahead stepahead NN cord-048446-gaemgm0t 104 6 residuals residual NNS cord-048446-gaemgm0t 104 7 are be VBP cord-048446-gaemgm0t 104 8 calculated calculate VBN cord-048446-gaemgm0t 104 9 as as IN cord-048446-gaemgm0t 104 10 We -PRON- PRP cord-048446-gaemgm0t 104 11 present present VBP cord-048446-gaemgm0t 104 12 these these DT cord-048446-gaemgm0t 104 13 residuals residual NNS cord-048446-gaemgm0t 104 14 averaged average VBN cord-048446-gaemgm0t 104 15 over over IN cord-048446-gaemgm0t 104 16 the the DT cord-048446-gaemgm0t 104 17 T T NNP cord-048446-gaemgm0t 104 18 days day NNS cord-048446-gaemgm0t 104 19 observed observe VBD cord-048446-gaemgm0t 104 20 . . . cord-048446-gaemgm0t 105 1 Generalizeability generalizeability NN cord-048446-gaemgm0t 105 2 of of IN cord-048446-gaemgm0t 105 3 the the DT cord-048446-gaemgm0t 105 4 results result NNS cord-048446-gaemgm0t 105 5 was be VBD cord-048446-gaemgm0t 105 6 studied study VBN cord-048446-gaemgm0t 105 7 using use VBG cord-048446-gaemgm0t 105 8 an an DT cord-048446-gaemgm0t 105 9 ad ad FW cord-048446-gaemgm0t 105 10 hoc hoc FW cord-048446-gaemgm0t 105 11 cross cross FW cord-048446-gaemgm0t 105 12 validation validation NN cord-048446-gaemgm0t 105 13 ( ( -LRB- cord-048446-gaemgm0t 105 14 CV cv NN cord-048446-gaemgm0t 105 15 ) ) -RRB- cord-048446-gaemgm0t 105 16 technique technique NN cord-048446-gaemgm0t 105 17 . . . cord-048446-gaemgm0t 106 1 This this DT cord-048446-gaemgm0t 106 2 is be VBZ cord-048446-gaemgm0t 106 3 done do VBN cord-048446-gaemgm0t 106 4 by by IN cord-048446-gaemgm0t 106 5 using use VBG cord-048446-gaemgm0t 106 6 the the DT cord-048446-gaemgm0t 106 7 estimates estimate NNS cord-048446-gaemgm0t 106 8 obtained obtain VBN cord-048446-gaemgm0t 106 9 from from IN cord-048446-gaemgm0t 106 10 one one CD cord-048446-gaemgm0t 106 11 location location NN cord-048446-gaemgm0t 106 12 to to TO cord-048446-gaemgm0t 106 13 calculate calculate VB cord-048446-gaemgm0t 106 14 the the DT cord-048446-gaemgm0t 106 15 one one CD cord-048446-gaemgm0t 106 16 step step NN cord-048446-gaemgm0t 106 17 ahead ahead RB cord-048446-gaemgm0t 106 18 residuals residual NNS cord-048446-gaemgm0t 106 19 for for IN cord-048446-gaemgm0t 106 20 another another DT cord-048446-gaemgm0t 106 21 location location NN cord-048446-gaemgm0t 106 22 . . . cord-048446-gaemgm0t 107 1 Specifically specifically RB cord-048446-gaemgm0t 107 2 we -PRON- PRP cord-048446-gaemgm0t 107 3 use use VBP cord-048446-gaemgm0t 107 4 the the DT cord-048446-gaemgm0t 107 5 Boonah Boonah NNP cord-048446-gaemgm0t 107 6 ship ship NN cord-048446-gaemgm0t 107 7 estimates estimate VBZ cord-048446-gaemgm0t 107 8 to to TO cord-048446-gaemgm0t 107 9 calculate calculate VB cord-048446-gaemgm0t 107 10 residuals residual NNS cord-048446-gaemgm0t 107 11 with with IN cord-048446-gaemgm0t 107 12 the the DT cord-048446-gaemgm0t 107 13 Medic Medic NNP cord-048446-gaemgm0t 107 14 data datum NNS cord-048446-gaemgm0t 107 15 and and CC cord-048446-gaemgm0t 107 16 then then RB cord-048446-gaemgm0t 107 17 use use VB cord-048446-gaemgm0t 107 18 the the DT cord-048446-gaemgm0t 107 19 Medic Medic NNP cord-048446-gaemgm0t 107 20 estimates estimate VBZ cord-048446-gaemgm0t 107 21 to to TO cord-048446-gaemgm0t 107 22 calculate calculate VB cord-048446-gaemgm0t 107 23 the the DT cord-048446-gaemgm0t 107 24 residuals residual NNS cord-048446-gaemgm0t 107 25 for for IN cord-048446-gaemgm0t 107 26 the the DT cord-048446-gaemgm0t 107 27 Boonah Boonah NNP cord-048446-gaemgm0t 107 28 data datum NNS cord-048446-gaemgm0t 107 29 . . . cord-048446-gaemgm0t 108 1 For for IN cord-048446-gaemgm0t 108 2 the the DT cord-048446-gaemgm0t 108 3 Maryland Maryland NNP cord-048446-gaemgm0t 108 4 communities community NNS cord-048446-gaemgm0t 108 5 , , , cord-048446-gaemgm0t 108 6 we -PRON- PRP cord-048446-gaemgm0t 108 7 report report VBP cord-048446-gaemgm0t 108 8 the the DT cord-048446-gaemgm0t 108 9 average average NN cord-048446-gaemgm0t 108 10 of of IN cord-048446-gaemgm0t 108 11 the the DT cord-048446-gaemgm0t 108 12 residuals residual NNS cord-048446-gaemgm0t 108 13 obtained obtain VBN cord-048446-gaemgm0t 108 14 using use VBG cord-048446-gaemgm0t 108 15 the the DT cord-048446-gaemgm0t 108 16 estimates estimate NNS cord-048446-gaemgm0t 108 17 from from IN cord-048446-gaemgm0t 108 18 one one CD cord-048446-gaemgm0t 108 19 community community NN cord-048446-gaemgm0t 108 20 to to TO cord-048446-gaemgm0t 108 21 predict predict VB cord-048446-gaemgm0t 108 22 the the DT cord-048446-gaemgm0t 108 23 epidemics epidemic NNS cord-048446-gaemgm0t 108 24 in in IN cord-048446-gaemgm0t 108 25 each each DT cord-048446-gaemgm0t 108 26 of of IN cord-048446-gaemgm0t 108 27 the the DT cord-048446-gaemgm0t 108 28 other other JJ cord-048446-gaemgm0t 108 29 four four CD cord-048446-gaemgm0t 108 30 communities community NNS cord-048446-gaemgm0t 108 31 , , , cord-048446-gaemgm0t 108 32 creating create VBG cord-048446-gaemgm0t 108 33 five five CD cord-048446-gaemgm0t 108 34 CV cv NN cord-048446-gaemgm0t 108 35 estimates estimate NNS cord-048446-gaemgm0t 108 36 ( ( -LRB- cord-048446-gaemgm0t 108 37 one one CD cord-048446-gaemgm0t 108 38 for for IN cord-048446-gaemgm0t 108 39 each each DT cord-048446-gaemgm0t 108 40 community community NN cord-048446-gaemgm0t 108 41 ) ) -RRB- cord-048446-gaemgm0t 108 42 . . . cord-048446-gaemgm0t 109 1 Table table NN cord-048446-gaemgm0t 109 2 2 2 CD cord-048446-gaemgm0t 109 3 gives give VBZ cord-048446-gaemgm0t 109 4 the the DT cord-048446-gaemgm0t 109 5 results result NNS cord-048446-gaemgm0t 109 6 for for IN cord-048446-gaemgm0t 109 7 the the DT cord-048446-gaemgm0t 109 8 serial serial JJ cord-048446-gaemgm0t 109 9 interval interval NN cord-048446-gaemgm0t 109 10 distribution distribution NN cord-048446-gaemgm0t 109 11 estimates estimate NNS cord-048446-gaemgm0t 109 12 . . . cord-048446-gaemgm0t 110 1 Notable notable JJ cord-048446-gaemgm0t 110 2 in in IN cord-048446-gaemgm0t 110 3 these these DT cord-048446-gaemgm0t 110 4 results result NNS cord-048446-gaemgm0t 110 5 is be VBZ cord-048446-gaemgm0t 110 6 the the DT cord-048446-gaemgm0t 110 7 striking striking JJ cord-048446-gaemgm0t 110 8 consistency consistency NN cord-048446-gaemgm0t 110 9 in in IN cord-048446-gaemgm0t 110 10 the the DT cord-048446-gaemgm0t 110 11 estimates estimate NNS cord-048446-gaemgm0t 110 12 of of IN cord-048446-gaemgm0t 110 13 the the DT cord-048446-gaemgm0t 110 14 first first JJ cord-048446-gaemgm0t 110 15 moment moment NN cord-048446-gaemgm0t 110 16 , , , cord-048446-gaemgm0t 110 17 with with IN cord-048446-gaemgm0t 110 18 the the DT cord-048446-gaemgm0t 110 19 exception exception NN cord-048446-gaemgm0t 110 20 of of IN cord-048446-gaemgm0t 110 21 Cumberland Cumberland NNP cord-048446-gaemgm0t 110 22 . . . cord-048446-gaemgm0t 111 1 The the DT cord-048446-gaemgm0t 111 2 second second JJ cord-048446-gaemgm0t 111 3 moments moment NNS cord-048446-gaemgm0t 111 4 vary vary VBP cord-048446-gaemgm0t 111 5 much much RB cord-048446-gaemgm0t 111 6 more more JJR cord-048446-gaemgm0t 111 7 , , , cord-048446-gaemgm0t 111 8 however however RB cord-048446-gaemgm0t 111 9 . . . cord-048446-gaemgm0t 112 1 In in IN cord-048446-gaemgm0t 112 2 general general JJ cord-048446-gaemgm0t 112 3 they -PRON- PRP cord-048446-gaemgm0t 112 4 tend tend VBP cord-048446-gaemgm0t 112 5 to to TO cord-048446-gaemgm0t 112 6 be be VB cord-048446-gaemgm0t 112 7 much much RB cord-048446-gaemgm0t 112 8 larger large JJR cord-048446-gaemgm0t 112 9 for for IN cord-048446-gaemgm0t 112 10 the the DT cord-048446-gaemgm0t 112 11 ships ship NNS cord-048446-gaemgm0t 112 12 when when WRB cord-048446-gaemgm0t 112 13 using use VBG cord-048446-gaemgm0t 112 14 the the DT cord-048446-gaemgm0t 112 15 Garske Garske NNP cord-048446-gaemgm0t 112 16 et et FW cord-048446-gaemgm0t 112 17 al al NNP cord-048446-gaemgm0t 112 18 . . . cord-048446-gaemgm0t 113 1 method method NN cord-048446-gaemgm0t 113 2 compared compare VBN cord-048446-gaemgm0t 113 3 to to IN cord-048446-gaemgm0t 113 4 the the DT cord-048446-gaemgm0t 113 5 MLE MLE NNP cord-048446-gaemgm0t 113 6 method method NN cord-048446-gaemgm0t 113 7 . . . cord-048446-gaemgm0t 114 1 For for IN cord-048446-gaemgm0t 114 2 the the DT cord-048446-gaemgm0t 114 3 communities community NNS cord-048446-gaemgm0t 114 4 , , , cord-048446-gaemgm0t 114 5 we -PRON- PRP cord-048446-gaemgm0t 114 6 observe observe VBP cord-048446-gaemgm0t 114 7 that that IN cord-048446-gaemgm0t 114 8 they -PRON- PRP cord-048446-gaemgm0t 114 9 are be VBP cord-048446-gaemgm0t 114 10 consistently consistently RB cord-048446-gaemgm0t 114 11 around around IN cord-048446-gaemgm0t 114 12 10 10 CD cord-048446-gaemgm0t 114 13 for for IN cord-048446-gaemgm0t 114 14 the the DT cord-048446-gaemgm0t 114 15 Garske Garske NNP cord-048446-gaemgm0t 114 16 et et FW cord-048446-gaemgm0t 114 17 al al NNP cord-048446-gaemgm0t 114 18 . . . cord-048446-gaemgm0t 115 1 method method NN cord-048446-gaemgm0t 115 2 and and CC cord-048446-gaemgm0t 115 3 vary vary VBP cord-048446-gaemgm0t 115 4 much much RB cord-048446-gaemgm0t 115 5 more more JJR cord-048446-gaemgm0t 115 6 for for IN cord-048446-gaemgm0t 115 7 the the DT cord-048446-gaemgm0t 115 8 MLE MLE NNP cord-048446-gaemgm0t 115 9 method method NN cord-048446-gaemgm0t 115 10 . . . cord-048446-gaemgm0t 116 1 Also also RB cord-048446-gaemgm0t 116 2 of of IN cord-048446-gaemgm0t 116 3 interest interest NN cord-048446-gaemgm0t 116 4 in in IN cord-048446-gaemgm0t 116 5 these these DT cord-048446-gaemgm0t 116 6 results result NNS cord-048446-gaemgm0t 116 7 are be VBP cord-048446-gaemgm0t 116 8 the the DT cord-048446-gaemgm0t 116 9 large large JJ cord-048446-gaemgm0t 116 10 error error NN cord-048446-gaemgm0t 116 11 estimates estimate NNS cord-048446-gaemgm0t 116 12 , , , cord-048446-gaemgm0t 116 13 particularly particularly RB cord-048446-gaemgm0t 116 14 for for IN cord-048446-gaemgm0t 116 15 Cumberland Cumberland NNP cord-048446-gaemgm0t 116 16 , , , cord-048446-gaemgm0t 116 17 but but CC cord-048446-gaemgm0t 116 18 also also RB cord-048446-gaemgm0t 116 19 to to IN cord-048446-gaemgm0t 116 20 a a DT cord-048446-gaemgm0t 116 21 smaller small JJR cord-048446-gaemgm0t 116 22 extent extent NN cord-048446-gaemgm0t 116 23 for for IN cord-048446-gaemgm0t 116 24 Frederick Frederick NNP cord-048446-gaemgm0t 116 25 . . . cord-048446-gaemgm0t 117 1 This this DT cord-048446-gaemgm0t 117 2 is be VBZ cord-048446-gaemgm0t 117 3 perhaps perhaps RB cord-048446-gaemgm0t 117 4 indicative indicative JJ cord-048446-gaemgm0t 117 5 of of IN cord-048446-gaemgm0t 117 6 the the DT cord-048446-gaemgm0t 117 7 model model NN cord-048446-gaemgm0t 117 8 not not RB cord-048446-gaemgm0t 117 9 fitting fit VBG cord-048446-gaemgm0t 117 10 the the DT cord-048446-gaemgm0t 117 11 data datum NNS cord-048446-gaemgm0t 117 12 as as RB cord-048446-gaemgm0t 117 13 well well RB cord-048446-gaemgm0t 117 14 , , , cord-048446-gaemgm0t 117 15 for for IN cord-048446-gaemgm0t 117 16 instance instance NN cord-048446-gaemgm0t 117 17 the the DT cord-048446-gaemgm0t 117 18 logistic logistic JJ cord-048446-gaemgm0t 117 19 model model NN cord-048446-gaemgm0t 117 20 may may MD cord-048446-gaemgm0t 117 21 not not RB cord-048446-gaemgm0t 117 22 be be VB cord-048446-gaemgm0t 117 23 the the DT cord-048446-gaemgm0t 117 24 best good JJS cord-048446-gaemgm0t 117 25 fit fit NN cord-048446-gaemgm0t 117 26 in in IN cord-048446-gaemgm0t 117 27 this this DT cord-048446-gaemgm0t 117 28 scenario scenario NN cord-048446-gaemgm0t 117 29 , , , cord-048446-gaemgm0t 117 30 or or CC cord-048446-gaemgm0t 117 31 that that IN cord-048446-gaemgm0t 117 32 the the DT cord-048446-gaemgm0t 117 33 lack lack NN cord-048446-gaemgm0t 117 34 of of IN cord-048446-gaemgm0t 117 35 census census NN cord-048446-gaemgm0t 117 36 data datum NNS cord-048446-gaemgm0t 117 37 on on IN cord-048446-gaemgm0t 117 38 cases case NNS cord-048446-gaemgm0t 117 39 might may MD cord-048446-gaemgm0t 117 40 be be VB cord-048446-gaemgm0t 117 41 more more RBR cord-048446-gaemgm0t 117 42 problematic problematic JJ cord-048446-gaemgm0t 117 43 here here RB cord-048446-gaemgm0t 117 44 . . . cord-048446-gaemgm0t 118 1 In in IN cord-048446-gaemgm0t 118 2 Table Table NNP cord-048446-gaemgm0t 118 3 3 3 CD cord-048446-gaemgm0t 118 4 and and CC cord-048446-gaemgm0t 118 5 Figure Figure NNP cord-048446-gaemgm0t 118 6 1 1 CD cord-048446-gaemgm0t 118 7 , , , cord-048446-gaemgm0t 118 8 we -PRON- PRP cord-048446-gaemgm0t 118 9 present present VBP cord-048446-gaemgm0t 118 10 the the DT cord-048446-gaemgm0t 118 11 results result NNS cord-048446-gaemgm0t 118 12 for for IN cord-048446-gaemgm0t 118 13 estimation estimation NN cord-048446-gaemgm0t 118 14 of of IN cord-048446-gaemgm0t 118 15 the the DT cord-048446-gaemgm0t 118 16 effective effective JJ cord-048446-gaemgm0t 118 17 reproductive reproductive JJ cord-048446-gaemgm0t 118 18 number number NN cord-048446-gaemgm0t 118 19 . . . cord-048446-gaemgm0t 119 1 Evident evident JJ cord-048446-gaemgm0t 119 2 in in IN cord-048446-gaemgm0t 119 3 these these DT cord-048446-gaemgm0t 119 4 results result NNS cord-048446-gaemgm0t 119 5 , , , cord-048446-gaemgm0t 119 6 is be VBZ cord-048446-gaemgm0t 119 7 the the DT cord-048446-gaemgm0t 119 8 large large JJ cord-048446-gaemgm0t 119 9 initial initial JJ cord-048446-gaemgm0t 119 10 reproductive reproductive JJ cord-048446-gaemgm0t 119 11 number number NN cord-048446-gaemgm0t 119 12 for for IN cord-048446-gaemgm0t 119 13 the the DT cord-048446-gaemgm0t 119 14 Boonah Boonah NNP cord-048446-gaemgm0t 119 15 ship ship NN cord-048446-gaemgm0t 119 16 . . . cord-048446-gaemgm0t 120 1 This this DT cord-048446-gaemgm0t 120 2 is be VBZ cord-048446-gaemgm0t 120 3 likely likely JJ cord-048446-gaemgm0t 120 4 due due IN cord-048446-gaemgm0t 120 5 to to IN cord-048446-gaemgm0t 120 6 some some DT cord-048446-gaemgm0t 120 7 of of IN cord-048446-gaemgm0t 120 8 the the DT cord-048446-gaemgm0t 120 9 missing miss VBG cord-048446-gaemgm0t 120 10 data datum NNS cord-048446-gaemgm0t 120 11 at at IN cord-048446-gaemgm0t 120 12 the the DT cord-048446-gaemgm0t 120 13 beginning beginning NN cord-048446-gaemgm0t 120 14 of of IN cord-048446-gaemgm0t 120 15 the the DT cord-048446-gaemgm0t 120 16 epidemic epidemic NN cord-048446-gaemgm0t 120 17 and and CC cord-048446-gaemgm0t 120 18 thus thus RB cord-048446-gaemgm0t 120 19 the the DT cord-048446-gaemgm0t 120 20 model model NN cord-048446-gaemgm0t 120 21 attributing attribute VBG cord-048446-gaemgm0t 120 22 the the DT cord-048446-gaemgm0t 120 23 large large JJ cord-048446-gaemgm0t 120 24 number number NN cord-048446-gaemgm0t 120 25 of of IN cord-048446-gaemgm0t 120 26 cases case NNS cord-048446-gaemgm0t 120 27 that that WDT cord-048446-gaemgm0t 120 28 rapidly rapidly RB cord-048446-gaemgm0t 120 29 develop develop VBP cord-048446-gaemgm0t 120 30 to to IN cord-048446-gaemgm0t 120 31 the the DT cord-048446-gaemgm0t 120 32 few few JJ cord-048446-gaemgm0t 120 33 individuals individual NNS cord-048446-gaemgm0t 120 34 who who WP cord-048446-gaemgm0t 120 35 were be VBD cord-048446-gaemgm0t 120 36 initially initially RB cord-048446-gaemgm0t 120 37 reported report VBN cord-048446-gaemgm0t 120 38 . . . cord-048446-gaemgm0t 121 1 The the DT cord-048446-gaemgm0t 121 2 logistic logistic JJ cord-048446-gaemgm0t 121 3 model model NN cord-048446-gaemgm0t 121 4 fits fit VBZ cord-048446-gaemgm0t 121 5 this this DT cord-048446-gaemgm0t 121 6 as as RB cord-048446-gaemgm0t 121 7 accurately accurately RB cord-048446-gaemgm0t 121 8 as as IN cord-048446-gaemgm0t 121 9 possible possible JJ cord-048446-gaemgm0t 121 10 , , , cord-048446-gaemgm0t 121 11 but but CC cord-048446-gaemgm0t 121 12 perhaps perhaps RB cord-048446-gaemgm0t 121 13 the the DT cord-048446-gaemgm0t 121 14 important important JJ cord-048446-gaemgm0t 121 15 message message NN cord-048446-gaemgm0t 121 16 is be VBZ cord-048446-gaemgm0t 121 17 the the DT cord-048446-gaemgm0t 121 18 qualitative qualitative JJ cord-048446-gaemgm0t 121 19 result result NN cord-048446-gaemgm0t 121 20 , , , cord-048446-gaemgm0t 121 21 indicating indicate VBG cord-048446-gaemgm0t 121 22 that that IN cord-048446-gaemgm0t 121 23 initial initial JJ cord-048446-gaemgm0t 121 24 transmission transmission NN cord-048446-gaemgm0t 121 25 in in IN cord-048446-gaemgm0t 121 26 this this DT cord-048446-gaemgm0t 121 27 susceptible susceptible JJ cord-048446-gaemgm0t 121 28 , , , cord-048446-gaemgm0t 121 29 non non JJ cord-048446-gaemgm0t 121 30 - - JJ cord-048446-gaemgm0t 121 31 quarantined quarantine VBN cord-048446-gaemgm0t 121 32 population population NN cord-048446-gaemgm0t 121 33 was be VBD cord-048446-gaemgm0t 121 34 very very RB cord-048446-gaemgm0t 121 35 high high JJ cord-048446-gaemgm0t 121 36 and and CC cord-048446-gaemgm0t 121 37 rapidly rapidly RB cord-048446-gaemgm0t 121 38 decreased decrease VBD cord-048446-gaemgm0t 121 39 as as RB cord-048446-gaemgm0t 121 40 many many JJ cord-048446-gaemgm0t 121 41 became become VBD cord-048446-gaemgm0t 121 42 infected infected JJ cord-048446-gaemgm0t 121 43 . . . cord-048446-gaemgm0t 122 1 The the DT cord-048446-gaemgm0t 122 2 result result NN cord-048446-gaemgm0t 122 3 is be VBZ cord-048446-gaemgm0t 122 4 similar similar JJ cord-048446-gaemgm0t 122 5 for for IN cord-048446-gaemgm0t 122 6 Medic Medic NNP cord-048446-gaemgm0t 122 7 though though IN cord-048446-gaemgm0t 122 8 the the DT cord-048446-gaemgm0t 122 9 initial initial JJ cord-048446-gaemgm0t 122 10 value value NN cord-048446-gaemgm0t 122 11 is be VBZ cord-048446-gaemgm0t 122 12 not not RB cord-048446-gaemgm0t 122 13 high high JJ cord-048446-gaemgm0t 122 14 . . . cord-048446-gaemgm0t 123 1 We -PRON- PRP cord-048446-gaemgm0t 123 2 also also RB cord-048446-gaemgm0t 123 3 note note VBP cord-048446-gaemgm0t 123 4 that that IN cord-048446-gaemgm0t 123 5 the the DT cord-048446-gaemgm0t 123 6 reproductive reproductive JJ cord-048446-gaemgm0t 123 7 number number NN cord-048446-gaemgm0t 123 8 dropped drop VBD cord-048446-gaemgm0t 123 9 to to TO cord-048446-gaemgm0t 123 10 sub sub VB cord-048446-gaemgm0t 123 11 epidemic epidemic JJ cord-048446-gaemgm0t 123 12 levels level NNS cord-048446-gaemgm0t 123 13 rapidly rapidly RB cord-048446-gaemgm0t 123 14 ( ( -LRB- cord-048446-gaemgm0t 123 15 around around IN cord-048446-gaemgm0t 123 16 10 10 CD cord-048446-gaemgm0t 123 17 days day NNS cord-048446-gaemgm0t 123 18 for for IN cord-048446-gaemgm0t 123 19 both both DT cord-048446-gaemgm0t 123 20 ships ship NNS cord-048446-gaemgm0t 123 21 ) ) -RRB- cord-048446-gaemgm0t 123 22 . . . cord-048446-gaemgm0t 124 1 In in IN cord-048446-gaemgm0t 124 2 the the DT cord-048446-gaemgm0t 124 3 Maryland Maryland NNP cord-048446-gaemgm0t 124 4 communities community NNS cord-048446-gaemgm0t 124 5 the the DT cord-048446-gaemgm0t 124 6 initial initial JJ cord-048446-gaemgm0t 124 7 reproductive reproductive JJ cord-048446-gaemgm0t 124 8 number number NN cord-048446-gaemgm0t 124 9 tended tend VBD cord-048446-gaemgm0t 124 10 to to TO cord-048446-gaemgm0t 124 11 be be VB cord-048446-gaemgm0t 124 12 slightly slightly RB cord-048446-gaemgm0t 124 13 lower low JJR cord-048446-gaemgm0t 124 14 ( ( -LRB- cord-048446-gaemgm0t 124 15 ranging range VBG cord-048446-gaemgm0t 124 16 from from IN cord-048446-gaemgm0t 124 17 1.34 1.34 CD cord-048446-gaemgm0t 124 18 in in IN cord-048446-gaemgm0t 124 19 Salisbury Salisbury NNP cord-048446-gaemgm0t 124 20 to to IN cord-048446-gaemgm0t 124 21 3.21 3.21 CD cord-048446-gaemgm0t 124 22 _SP cord-048446-gaemgm0t 125 1 In in IN cord-048446-gaemgm0t 125 2 Table Table NNP cord-048446-gaemgm0t 125 3 4 4 CD cord-048446-gaemgm0t 125 4 , , , cord-048446-gaemgm0t 125 5 we -PRON- PRP cord-048446-gaemgm0t 125 6 present present VBP cord-048446-gaemgm0t 125 7 the the DT cord-048446-gaemgm0t 125 8 results result NNS cord-048446-gaemgm0t 125 9 of of IN cord-048446-gaemgm0t 125 10 the the DT cord-048446-gaemgm0t 125 11 residual residual JJ cord-048446-gaemgm0t 125 12 analysis analysis NN cord-048446-gaemgm0t 125 13 . . . cord-048446-gaemgm0t 126 1 We -PRON- PRP cord-048446-gaemgm0t 126 2 notice notice VBP cord-048446-gaemgm0t 126 3 here here RB cord-048446-gaemgm0t 126 4 that that IN cord-048446-gaemgm0t 126 5 the the DT cord-048446-gaemgm0t 126 6 Garske Garske NNP cord-048446-gaemgm0t 126 7 et et FW cord-048446-gaemgm0t 126 8 al al NNP cord-048446-gaemgm0t 126 9 . . . cord-048446-gaemgm0t 127 1 method method NN cord-048446-gaemgm0t 127 2 often often RB cord-048446-gaemgm0t 127 3 does do VBZ cord-048446-gaemgm0t 127 4 better well RBR cord-048446-gaemgm0t 127 5 than than IN cord-048446-gaemgm0t 127 6 the the DT cord-048446-gaemgm0t 127 7 MLE MLE NNP cord-048446-gaemgm0t 127 8 method method NN cord-048446-gaemgm0t 127 9 . . . cord-048446-gaemgm0t 128 1 It -PRON- PRP cord-048446-gaemgm0t 128 2 is be VBZ cord-048446-gaemgm0t 128 3 important important JJ cord-048446-gaemgm0t 128 4 to to TO cord-048446-gaemgm0t 128 5 point point VB cord-048446-gaemgm0t 128 6 out out RP cord-048446-gaemgm0t 128 7 that that IN cord-048446-gaemgm0t 128 8 the the DT cord-048446-gaemgm0t 128 9 WT WT NNP cord-048446-gaemgm0t 128 10 method method NN cord-048446-gaemgm0t 128 11 of of IN cord-048446-gaemgm0t 128 12 fitting fit VBG cord-048446-gaemgm0t 128 13 the the DT cord-048446-gaemgm0t 128 14 effective effective JJ cord-048446-gaemgm0t 128 15 reproductive reproductive JJ cord-048446-gaemgm0t 128 16 model model NN cord-048446-gaemgm0t 128 17 over over IN cord-048446-gaemgm0t 128 18 fits fit VBZ cord-048446-gaemgm0t 128 19 the the DT cord-048446-gaemgm0t 128 20 model model NN cord-048446-gaemgm0t 128 21 and and CC cord-048446-gaemgm0t 128 22 suffers suffer VBZ cord-048446-gaemgm0t 128 23 from from IN cord-048446-gaemgm0t 128 24 generalizeability generalizeability NN cord-048446-gaemgm0t 128 25 . . . cord-048446-gaemgm0t 129 1 This this DT cord-048446-gaemgm0t 129 2 method method NN cord-048446-gaemgm0t 129 3 essentially essentially RB cord-048446-gaemgm0t 129 4 traces trace VBZ cord-048446-gaemgm0t 129 5 the the DT cord-048446-gaemgm0t 129 6 epidemic epidemic NN cord-048446-gaemgm0t 129 7 curve curve NN cord-048446-gaemgm0t 129 8 , , , cord-048446-gaemgm0t 129 9 lagged lag VBN cord-048446-gaemgm0t 129 10 by by IN cord-048446-gaemgm0t 129 11 the the DT cord-048446-gaemgm0t 129 12 mean mean NN cord-048446-gaemgm0t 129 13 of of IN cord-048446-gaemgm0t 129 14 the the DT cord-048446-gaemgm0t 129 15 generation generation NN cord-048446-gaemgm0t 129 16 time time NN cord-048446-gaemgm0t 129 17 distribution distribution NN cord-048446-gaemgm0t 129 18 . . . cord-048446-gaemgm0t 130 1 Thus thus RB cord-048446-gaemgm0t 130 2 , , , cord-048446-gaemgm0t 130 3 according accord VBG cord-048446-gaemgm0t 130 4 to to IN cord-048446-gaemgm0t 130 5 the the DT cord-048446-gaemgm0t 130 6 residuals residual NNS cord-048446-gaemgm0t 130 7 , , , cord-048446-gaemgm0t 130 8 it -PRON- PRP cord-048446-gaemgm0t 130 9 appears appear VBZ cord-048446-gaemgm0t 130 10 that that IN cord-048446-gaemgm0t 130 11 the the DT cord-048446-gaemgm0t 130 12 WT WT NNP cord-048446-gaemgm0t 130 13 method method NN cord-048446-gaemgm0t 130 14 outperforms outperform VBZ cord-048446-gaemgm0t 130 15 the the DT cord-048446-gaemgm0t 130 16 MLE MLE NNP cord-048446-gaemgm0t 130 17 . . . cord-048446-gaemgm0t 131 1 However however RB cord-048446-gaemgm0t 131 2 , , , cord-048446-gaemgm0t 131 3 considering consider VBG cord-048446-gaemgm0t 131 4 the the DT cord-048446-gaemgm0t 131 5 importance importance NN cord-048446-gaemgm0t 131 6 of of IN cord-048446-gaemgm0t 131 7 external external JJ cord-048446-gaemgm0t 131 8 validation validation NN cord-048446-gaemgm0t 131 9 and and CC cord-048446-gaemgm0t 131 10 reproducibility reproducibility NN cord-048446-gaemgm0t 131 11 , , , cord-048446-gaemgm0t 131 12 the the DT cord-048446-gaemgm0t 131 13 model model NN cord-048446-gaemgm0t 131 14 suffers suffer VBZ cord-048446-gaemgm0t 131 15 somewhat somewhat RB cord-048446-gaemgm0t 131 16 as as IN cord-048446-gaemgm0t 131 17 evidenced evidence VBN cord-048446-gaemgm0t 131 18 by by IN cord-048446-gaemgm0t 131 19 the the DT cord-048446-gaemgm0t 131 20 CV CV NNP cord-048446-gaemgm0t 131 21 measures measure NNS cord-048446-gaemgm0t 131 22 . . . cord-048446-gaemgm0t 132 1 The the DT cord-048446-gaemgm0t 132 2 exceptions exception NNS cord-048446-gaemgm0t 132 3 to to IN cord-048446-gaemgm0t 132 4 this this DT cord-048446-gaemgm0t 132 5 are be VBP cord-048446-gaemgm0t 132 6 in in IN cord-048446-gaemgm0t 132 7 the the DT cord-048446-gaemgm0t 132 8 case case NN cord-048446-gaemgm0t 132 9 of of IN cord-048446-gaemgm0t 132 10 the the DT cord-048446-gaemgm0t 132 11 Boonah Boonah NNP cord-048446-gaemgm0t 132 12 where where WRB cord-048446-gaemgm0t 132 13 the the DT cord-048446-gaemgm0t 132 14 CV CV NNP cord-048446-gaemgm0t 132 15 measure measure NN cord-048446-gaemgm0t 132 16 is be VBZ cord-048446-gaemgm0t 132 17 impacted impact VBN cord-048446-gaemgm0t 132 18 by by IN cord-048446-gaemgm0t 132 19 the the DT cord-048446-gaemgm0t 132 20 large large JJ cord-048446-gaemgm0t 132 21 initial initial JJ cord-048446-gaemgm0t 132 22 MLE MLE NNP cord-048446-gaemgm0t 132 23 estimate estimate NN cord-048446-gaemgm0t 132 24 of of IN cord-048446-gaemgm0t 132 25 the the DT cord-048446-gaemgm0t 132 26 reproductive reproductive JJ cord-048446-gaemgm0t 132 27 number number NN cord-048446-gaemgm0t 132 28 and and CC cord-048446-gaemgm0t 132 29 in in IN cord-048446-gaemgm0t 132 30 Cumberland Cumberland NNP cord-048446-gaemgm0t 132 31 where where WRB cord-048446-gaemgm0t 132 32 it -PRON- PRP cord-048446-gaemgm0t 132 33 appears appear VBZ cord-048446-gaemgm0t 132 34 that that IN cord-048446-gaemgm0t 132 35 either either CC cord-048446-gaemgm0t 132 36 the the DT cord-048446-gaemgm0t 132 37 parametric parametric JJ cord-048446-gaemgm0t 132 38 model model NN cord-048446-gaemgm0t 132 39 chosen choose VBN cord-048446-gaemgm0t 132 40 may may MD cord-048446-gaemgm0t 132 41 not not RB cord-048446-gaemgm0t 132 42 represent represent VB cord-048446-gaemgm0t 132 43 the the DT cord-048446-gaemgm0t 132 44 best good JJS cord-048446-gaemgm0t 132 45 fit fit NN cord-048446-gaemgm0t 132 46 to to IN cord-048446-gaemgm0t 132 47 the the DT cord-048446-gaemgm0t 132 48 data datum NNS cord-048446-gaemgm0t 132 49 or or CC cord-048446-gaemgm0t 132 50 there there EX cord-048446-gaemgm0t 132 51 were be VBD cord-048446-gaemgm0t 132 52 sensitivities sensitivity NNS cord-048446-gaemgm0t 132 53 to to IN cord-048446-gaemgm0t 132 54 the the DT cord-048446-gaemgm0t 132 55 survey survey NN cord-048446-gaemgm0t 132 56 data datum NNS cord-048446-gaemgm0t 132 57 . . . cord-048446-gaemgm0t 132 58 _SP cord-048446-gaemgm0t 133 1 We -PRON- PRP cord-048446-gaemgm0t 133 2 have have VBP cord-048446-gaemgm0t 133 3 presented present VBN cord-048446-gaemgm0t 133 4 results result NNS cord-048446-gaemgm0t 133 5 that that WDT cord-048446-gaemgm0t 133 6 are be VBP cord-048446-gaemgm0t 133 7 informative informative JJ cord-048446-gaemgm0t 133 8 with with IN cord-048446-gaemgm0t 133 9 regard regard NN cord-048446-gaemgm0t 133 10 to to IN cord-048446-gaemgm0t 133 11 the the DT cord-048446-gaemgm0t 133 12 dynamics dynamic NNS cord-048446-gaemgm0t 133 13 of of IN cord-048446-gaemgm0t 133 14 the the DT cord-048446-gaemgm0t 133 15 1918 1918 CD cord-048446-gaemgm0t 133 16 influenza influenza NN cord-048446-gaemgm0t 133 17 pandemic pandemic NN cord-048446-gaemgm0t 133 18 in in IN cord-048446-gaemgm0t 133 19 different different JJ cord-048446-gaemgm0t 133 20 populations population NNS cord-048446-gaemgm0t 133 21 and and CC cord-048446-gaemgm0t 133 22 provide provide VB cord-048446-gaemgm0t 133 23 insight insight NN cord-048446-gaemgm0t 133 24 into into IN cord-048446-gaemgm0t 133 25 two two CD cord-048446-gaemgm0t 133 26 methodologies methodology NNS cord-048446-gaemgm0t 133 27 for for IN cord-048446-gaemgm0t 133 28 estimating estimate VBG cord-048446-gaemgm0t 133 29 basic basic JJ cord-048446-gaemgm0t 133 30 epidemiological epidemiological JJ cord-048446-gaemgm0t 133 31 parameters parameter NNS cord-048446-gaemgm0t 133 32 . . . cord-048446-gaemgm0t 134 1 Both both DT cord-048446-gaemgm0t 134 2 methods method NNS cord-048446-gaemgm0t 134 3 assume assume VBP cord-048446-gaemgm0t 134 4 that that IN cord-048446-gaemgm0t 134 5 the the DT cord-048446-gaemgm0t 134 6 population population NN cord-048446-gaemgm0t 134 7 is be VBZ cord-048446-gaemgm0t 134 8 closed closed JJ cord-048446-gaemgm0t 134 9 , , , cord-048446-gaemgm0t 134 10 there there EX cord-048446-gaemgm0t 134 11 are be VBP cord-048446-gaemgm0t 134 12 no no DT cord-048446-gaemgm0t 134 13 missing miss VBG cord-048446-gaemgm0t 134 14 cases case NNS cord-048446-gaemgm0t 134 15 and and CC cord-048446-gaemgm0t 134 16 no no DT cord-048446-gaemgm0t 134 17 migration migration NN cord-048446-gaemgm0t 134 18 to to IN cord-048446-gaemgm0t 134 19 or or CC cord-048446-gaemgm0t 134 20 from from IN cord-048446-gaemgm0t 134 21 the the DT cord-048446-gaemgm0t 134 22 population population NN cord-048446-gaemgm0t 134 23 . . . cord-048446-gaemgm0t 135 1 The the DT cord-048446-gaemgm0t 135 2 second second JJ cord-048446-gaemgm0t 135 3 of of IN cord-048446-gaemgm0t 135 4 these these DT cord-048446-gaemgm0t 135 5 assumptions assumption NNS cord-048446-gaemgm0t 135 6 is be VBZ cord-048446-gaemgm0t 135 7 clearly clearly RB cord-048446-gaemgm0t 135 8 violated violate VBN cord-048446-gaemgm0t 135 9 with with IN cord-048446-gaemgm0t 135 10 the the DT cord-048446-gaemgm0t 135 11 data datum NNS cord-048446-gaemgm0t 135 12 from from IN cord-048446-gaemgm0t 135 13 Maryland Maryland NNP cord-048446-gaemgm0t 135 14 ; ; : cord-048446-gaemgm0t 135 15 however however RB cord-048446-gaemgm0t 135 16 the the DT cord-048446-gaemgm0t 135 17 results result NNS cord-048446-gaemgm0t 135 18 appear appear VBP cord-048446-gaemgm0t 135 19 to to TO cord-048446-gaemgm0t 135 20 be be VB cord-048446-gaemgm0t 135 21 reasonably reasonably RB cord-048446-gaemgm0t 135 22 robust robust JJ cord-048446-gaemgm0t 135 23 to to IN cord-048446-gaemgm0t 135 24 this this DT cord-048446-gaemgm0t 135 25 discrepancy discrepancy NN cord-048446-gaemgm0t 135 26 , , , cord-048446-gaemgm0t 135 27 except except IN cord-048446-gaemgm0t 135 28 in in IN cord-048446-gaemgm0t 135 29 the the DT cord-048446-gaemgm0t 135 30 case case NN cord-048446-gaemgm0t 135 31 of of IN cord-048446-gaemgm0t 135 32 Cumberland Cumberland NNP cord-048446-gaemgm0t 135 33 . . . cord-048446-gaemgm0t 136 1 The the DT cord-048446-gaemgm0t 136 2 purpose purpose NN cord-048446-gaemgm0t 136 3 of of IN cord-048446-gaemgm0t 136 4 this this DT cord-048446-gaemgm0t 136 5 exercise exercise NN cord-048446-gaemgm0t 136 6 determines determine VBZ cord-048446-gaemgm0t 136 7 to to IN cord-048446-gaemgm0t 136 8 some some DT cord-048446-gaemgm0t 136 9 extent extent NN cord-048446-gaemgm0t 136 10 which which WDT cord-048446-gaemgm0t 136 11 methodological methodological JJ cord-048446-gaemgm0t 136 12 approach approach NN cord-048446-gaemgm0t 136 13 we -PRON- PRP cord-048446-gaemgm0t 136 14 might may MD cord-048446-gaemgm0t 136 15 favor favor VB cord-048446-gaemgm0t 136 16 . . . cord-048446-gaemgm0t 137 1 If if IN cord-048446-gaemgm0t 137 2 the the DT cord-048446-gaemgm0t 137 3 intent intent NN cord-048446-gaemgm0t 137 4 is be VBZ cord-048446-gaemgm0t 137 5 to to TO cord-048446-gaemgm0t 137 6 simply simply RB cord-048446-gaemgm0t 137 7 estimate estimate VB cord-048446-gaemgm0t 137 8 the the DT cord-048446-gaemgm0t 137 9 parameters parameter NNS cord-048446-gaemgm0t 137 10 for for IN cord-048446-gaemgm0t 137 11 a a DT cord-048446-gaemgm0t 137 12 specific specific JJ cord-048446-gaemgm0t 137 13 epidemic epidemic NN cord-048446-gaemgm0t 137 14 and and CC cord-048446-gaemgm0t 137 15 better well RBR cord-048446-gaemgm0t 137 16 understand understand VB cord-048446-gaemgm0t 137 17 what what WP cord-048446-gaemgm0t 137 18 exactly exactly RB cord-048446-gaemgm0t 137 19 was be VBD cord-048446-gaemgm0t 137 20 occurring occur VBG cord-048446-gaemgm0t 137 21 in in IN cord-048446-gaemgm0t 137 22 that that DT cord-048446-gaemgm0t 137 23 setting setting NN cord-048446-gaemgm0t 137 24 , , , cord-048446-gaemgm0t 137 25 then then RB cord-048446-gaemgm0t 137 26 the the DT cord-048446-gaemgm0t 137 27 method method NN cord-048446-gaemgm0t 137 28 presented present VBN cord-048446-gaemgm0t 137 29 by by IN cord-048446-gaemgm0t 137 30 [ [ -LRB- cord-048446-gaemgm0t 137 31 12 12 CD cord-048446-gaemgm0t 137 32 ] ] -RRB- cord-048446-gaemgm0t 137 33 ( ( -LRB- cord-048446-gaemgm0t 137 34 Garske Garske NNP cord-048446-gaemgm0t 137 35 et et FW cord-048446-gaemgm0t 137 36 al al NNP cord-048446-gaemgm0t 137 37 . . . cord-048446-gaemgm0t 137 38 ) ) -RRB- cord-048446-gaemgm0t 137 39 appears appear VBZ cord-048446-gaemgm0t 137 40 to to TO cord-048446-gaemgm0t 137 41 provide provide VB cord-048446-gaemgm0t 137 42 good good JJ cord-048446-gaemgm0t 137 43 fit fit NN cord-048446-gaemgm0t 137 44 . . . cord-048446-gaemgm0t 138 1 The the DT cord-048446-gaemgm0t 138 2 caveat caveat NN cord-048446-gaemgm0t 138 3 that that WDT cord-048446-gaemgm0t 138 4 we -PRON- PRP cord-048446-gaemgm0t 138 5 see see VBP cord-048446-gaemgm0t 138 6 in in IN cord-048446-gaemgm0t 138 7 this this DT cord-048446-gaemgm0t 138 8 method method NN cord-048446-gaemgm0t 138 9 is be VBZ cord-048446-gaemgm0t 138 10 that that IN cord-048446-gaemgm0t 138 11 by by IN cord-048446-gaemgm0t 138 12 estimating estimate VBG cord-048446-gaemgm0t 138 13 the the DT cord-048446-gaemgm0t 138 14 effective effective JJ cord-048446-gaemgm0t 138 15 reproductive reproductive JJ cord-048446-gaemgm0t 138 16 number number NN cord-048446-gaemgm0t 138 17 with with IN cord-048446-gaemgm0t 138 18 the the DT cord-048446-gaemgm0t 138 19 methodology methodology NN cord-048446-gaemgm0t 138 20 of of IN cord-048446-gaemgm0t 138 21 [ [ -LRB- cord-048446-gaemgm0t 138 22 7 7 CD cord-048446-gaemgm0t 138 23 ] ] -RRB- cord-048446-gaemgm0t 138 24 ( ( -LRB- cord-048446-gaemgm0t 138 25 WT WT NNP cord-048446-gaemgm0t 138 26 ) ) -RRB- cord-048446-gaemgm0t 139 1 there there EX cord-048446-gaemgm0t 139 2 is be VBZ cord-048446-gaemgm0t 139 3 an an DT cord-048446-gaemgm0t 139 4 over over IN cord-048446-gaemgm0t 139 5 fit fit NN cord-048446-gaemgm0t 139 6 of of IN cord-048446-gaemgm0t 139 7 this this DT cord-048446-gaemgm0t 139 8 parameter parameter NN cord-048446-gaemgm0t 139 9 and and CC cord-048446-gaemgm0t 139 10 it -PRON- PRP cord-048446-gaemgm0t 139 11 essentially essentially RB cord-048446-gaemgm0t 139 12 traces trace VBZ cord-048446-gaemgm0t 139 13 the the DT cord-048446-gaemgm0t 139 14 epidemic epidemic NN cord-048446-gaemgm0t 139 15 curve curve NN cord-048446-gaemgm0t 139 16 , , , cord-048446-gaemgm0t 139 17 lagged lag VBN cord-048446-gaemgm0t 139 18 by by IN cord-048446-gaemgm0t 139 19 the the DT cord-048446-gaemgm0t 139 20 mean mean NN cord-048446-gaemgm0t 139 21 of of IN cord-048446-gaemgm0t 139 22 the the DT cord-048446-gaemgm0t 139 23 serial serial JJ cord-048446-gaemgm0t 139 24 interval interval NN cord-048446-gaemgm0t 139 25 . . . cord-048446-gaemgm0t 140 1 It -PRON- PRP cord-048446-gaemgm0t 140 2 is be VBZ cord-048446-gaemgm0t 140 3 not not RB cord-048446-gaemgm0t 140 4 clear clear JJ cord-048446-gaemgm0t 140 5 if if IN cord-048446-gaemgm0t 140 6 this this DT cord-048446-gaemgm0t 140 7 is be VBZ cord-048446-gaemgm0t 140 8 a a DT cord-048446-gaemgm0t 140 9 desirable desirable JJ cord-048446-gaemgm0t 140 10 or or CC cord-048446-gaemgm0t 140 11 informative informative JJ cord-048446-gaemgm0t 140 12 property property NN cord-048446-gaemgm0t 140 13 . . . cord-048446-gaemgm0t 141 1 The the DT cord-048446-gaemgm0t 141 2 MLE MLE NNP cord-048446-gaemgm0t 141 3 method method NN cord-048446-gaemgm0t 141 4 has have VBZ cord-048446-gaemgm0t 141 5 greater great JJR cord-048446-gaemgm0t 141 6 promise promise NN cord-048446-gaemgm0t 141 7 for for IN cord-048446-gaemgm0t 141 8 generalizeability generalizeability NN cord-048446-gaemgm0t 141 9 . . . cord-048446-gaemgm0t 142 1 While while IN cord-048446-gaemgm0t 142 2 it -PRON- PRP cord-048446-gaemgm0t 142 3 can can MD cord-048446-gaemgm0t 142 4 be be VB cord-048446-gaemgm0t 142 5 argued argue VBN cord-048446-gaemgm0t 142 6 that that IN cord-048446-gaemgm0t 142 7 adhering adhere VBG cord-048446-gaemgm0t 142 8 to to IN cord-048446-gaemgm0t 142 9 a a DT cord-048446-gaemgm0t 142 10 parametric parametric JJ cord-048446-gaemgm0t 142 11 definition definition NN cord-048446-gaemgm0t 142 12 of of IN cord-048446-gaemgm0t 142 13 the the DT cord-048446-gaemgm0t 142 14 shape shape NN cord-048446-gaemgm0t 142 15 of of IN cord-048446-gaemgm0t 142 16 the the DT cord-048446-gaemgm0t 142 17 effective effective JJ cord-048446-gaemgm0t 142 18 reproductive reproductive JJ cord-048446-gaemgm0t 142 19 number number NN cord-048446-gaemgm0t 142 20 leads lead VBZ cord-048446-gaemgm0t 142 21 to to IN cord-048446-gaemgm0t 142 22 a a DT cord-048446-gaemgm0t 142 23 greater great JJR cord-048446-gaemgm0t 142 24 chance chance NN cord-048446-gaemgm0t 142 25 of of IN cord-048446-gaemgm0t 142 26 lack lack NN cord-048446-gaemgm0t 142 27 of of IN cord-048446-gaemgm0t 142 28 fit fit NN cord-048446-gaemgm0t 142 29 , , , cord-048446-gaemgm0t 142 30 it -PRON- PRP cord-048446-gaemgm0t 142 31 can can MD cord-048446-gaemgm0t 142 32 also also RB cord-048446-gaemgm0t 142 33 lead lead VB cord-048446-gaemgm0t 142 34 to to IN cord-048446-gaemgm0t 142 35 a a DT cord-048446-gaemgm0t 142 36 result result NN cord-048446-gaemgm0t 142 37 that that WDT cord-048446-gaemgm0t 142 38 can can MD cord-048446-gaemgm0t 142 39 be be VB cord-048446-gaemgm0t 142 40 interpretable interpretable JJ cord-048446-gaemgm0t 142 41 for for IN cord-048446-gaemgm0t 142 42 other other JJ cord-048446-gaemgm0t 142 43 settings setting NNS cord-048446-gaemgm0t 142 44 that that WDT cord-048446-gaemgm0t 142 45 are be VBP cord-048446-gaemgm0t 142 46 similar similar JJ cord-048446-gaemgm0t 142 47 to to IN cord-048446-gaemgm0t 142 48 that that DT cord-048446-gaemgm0t 142 49 being be VBG cord-048446-gaemgm0t 142 50 studied study VBN cord-048446-gaemgm0t 142 51 . . . cord-048446-gaemgm0t 143 1 One one PRP cord-048446-gaemgm0t 143 2 can can MD cord-048446-gaemgm0t 143 3 choose choose VB cord-048446-gaemgm0t 143 4 any any DT cord-048446-gaemgm0t 143 5 reasonable reasonable JJ cord-048446-gaemgm0t 143 6 parametric parametric JJ cord-048446-gaemgm0t 143 7 form form NN cord-048446-gaemgm0t 143 8 for for IN cord-048446-gaemgm0t 143 9 modeling model VBG cord-048446-gaemgm0t 143 10 the the DT cord-048446-gaemgm0t 143 11 effective effective JJ cord-048446-gaemgm0t 143 12 reproductive reproductive JJ cord-048446-gaemgm0t 143 13 number number NN cord-048446-gaemgm0t 143 14 . . . cord-048446-gaemgm0t 144 1 Here here RB cord-048446-gaemgm0t 144 2 we -PRON- PRP cord-048446-gaemgm0t 144 3 have have VBP cord-048446-gaemgm0t 144 4 only only RB cord-048446-gaemgm0t 144 5 shown show VBN cord-048446-gaemgm0t 144 6 the the DT cord-048446-gaemgm0t 144 7 four four CD cord-048446-gaemgm0t 144 8 parameter parameter NN cord-048446-gaemgm0t 144 9 logistic logistic JJ cord-048446-gaemgm0t 144 10 model model NN cord-048446-gaemgm0t 144 11 , , , cord-048446-gaemgm0t 144 12 and and CC cord-048446-gaemgm0t 144 13 feel feel VB cord-048446-gaemgm0t 144 14 that that IN cord-048446-gaemgm0t 144 15 it -PRON- PRP cord-048446-gaemgm0t 144 16 is be VBZ cord-048446-gaemgm0t 144 17 suitable suitable JJ cord-048446-gaemgm0t 144 18 in in IN cord-048446-gaemgm0t 144 19 most most JJS cord-048446-gaemgm0t 144 20 cases case NNS cord-048446-gaemgm0t 144 21 where where WRB cord-048446-gaemgm0t 144 22 the the DT cord-048446-gaemgm0t 144 23 epidemic epidemic NN cord-048446-gaemgm0t 144 24 curve curve NN cord-048446-gaemgm0t 144 25 has have VBZ cord-048446-gaemgm0t 144 26 a a DT cord-048446-gaemgm0t 144 27 single single JJ cord-048446-gaemgm0t 144 28 peak peak NN cord-048446-gaemgm0t 144 29 . . . cord-048446-gaemgm0t 145 1 It -PRON- PRP cord-048446-gaemgm0t 145 2 is be VBZ cord-048446-gaemgm0t 145 3 feasible feasible JJ cord-048446-gaemgm0t 145 4 that that IN cord-048446-gaemgm0t 145 5 this this DT cord-048446-gaemgm0t 145 6 model model NN cord-048446-gaemgm0t 145 7 may may MD cord-048446-gaemgm0t 145 8 not not RB cord-048446-gaemgm0t 145 9 apply apply VB cord-048446-gaemgm0t 145 10 well well RB cord-048446-gaemgm0t 145 11 in in IN cord-048446-gaemgm0t 145 12 all all DT cord-048446-gaemgm0t 145 13 situations situation NNS cord-048446-gaemgm0t 145 14 . . . cord-048446-gaemgm0t 146 1 Another another DT cord-048446-gaemgm0t 146 2 approach approach NN cord-048446-gaemgm0t 146 3 might may MD cord-048446-gaemgm0t 146 4 be be VB cord-048446-gaemgm0t 146 5 to to TO cord-048446-gaemgm0t 146 6 analyze analyze VB cord-048446-gaemgm0t 146 7 the the DT cord-048446-gaemgm0t 146 8 data datum NNS cord-048446-gaemgm0t 146 9 using use VBG cord-048446-gaemgm0t 146 10 the the DT cord-048446-gaemgm0t 146 11 Garske Garske NNP cord-048446-gaemgm0t 146 12 et et FW cord-048446-gaemgm0t 146 13 al al NNP cord-048446-gaemgm0t 146 14 . . . cord-048446-gaemgm0t 147 1 method method NN cord-048446-gaemgm0t 147 2 and and CC cord-048446-gaemgm0t 147 3 then then RB cord-048446-gaemgm0t 147 4 smooth smooth VB cord-048446-gaemgm0t 147 5 the the DT cord-048446-gaemgm0t 147 6 plot plot NN cord-048446-gaemgm0t 147 7 of of IN cord-048446-gaemgm0t 147 8 the the DT cord-048446-gaemgm0t 147 9 effective effective JJ cord-048446-gaemgm0t 147 10 reproductive reproductive JJ cord-048446-gaemgm0t 147 11 number number NN cord-048446-gaemgm0t 147 12 and and CC cord-048446-gaemgm0t 147 13 from from IN cord-048446-gaemgm0t 147 14 this this DT cord-048446-gaemgm0t 147 15 determine determine NN cord-048446-gaemgm0t 147 16 a a DT cord-048446-gaemgm0t 147 17 parametric parametric JJ cord-048446-gaemgm0t 147 18 form form NN cord-048446-gaemgm0t 147 19 that that WDT cord-048446-gaemgm0t 147 20 closely closely RB cord-048446-gaemgm0t 147 21 approximates approximate VBZ cord-048446-gaemgm0t 147 22 the the DT cord-048446-gaemgm0t 147 23 smoothed smooth VBN cord-048446-gaemgm0t 147 24 curve curve NN cord-048446-gaemgm0t 147 25 . . . cord-048446-gaemgm0t 148 1 Multiple multiple JJ cord-048446-gaemgm0t 148 2 models model NNS cord-048446-gaemgm0t 148 3 could could MD cord-048446-gaemgm0t 148 4 be be VB cord-048446-gaemgm0t 148 5 implemented implement VBN cord-048446-gaemgm0t 148 6 , , , cord-048446-gaemgm0t 148 7 then then RB cord-048446-gaemgm0t 148 8 the the DT cord-048446-gaemgm0t 148 9 residual residual JJ cord-048446-gaemgm0t 148 10 analysis analysis NN cord-048446-gaemgm0t 148 11 that that WDT cord-048446-gaemgm0t 148 12 we -PRON- PRP cord-048446-gaemgm0t 148 13 have have VBP cord-048446-gaemgm0t 148 14 shown show VBN cord-048446-gaemgm0t 148 15 provides provide VBZ cord-048446-gaemgm0t 148 16 a a DT cord-048446-gaemgm0t 148 17 valuable valuable JJ cord-048446-gaemgm0t 148 18 tool tool NN cord-048446-gaemgm0t 148 19 for for IN cord-048446-gaemgm0t 148 20 model model NN cord-048446-gaemgm0t 148 21 assessment assessment NN cord-048446-gaemgm0t 148 22 and and CC cord-048446-gaemgm0t 148 23 comparison comparison NN cord-048446-gaemgm0t 148 24 . . . cord-048446-gaemgm0t 149 1 The the DT cord-048446-gaemgm0t 149 2 results result NNS cord-048446-gaemgm0t 149 3 of of IN cord-048446-gaemgm0t 149 4 these these DT cord-048446-gaemgm0t 149 5 models model NNS cord-048446-gaemgm0t 149 6 can can MD cord-048446-gaemgm0t 149 7 be be VB cord-048446-gaemgm0t 149 8 sensitive sensitive JJ cord-048446-gaemgm0t 149 9 to to IN cord-048446-gaemgm0t 149 10 underreporting underreporte VBG cord-048446-gaemgm0t 149 11 initially initially RB cord-048446-gaemgm0t 149 12 in in IN cord-048446-gaemgm0t 149 13 the the DT cord-048446-gaemgm0t 149 14 epidemic epidemic NN cord-048446-gaemgm0t 149 15 . . . cord-048446-gaemgm0t 150 1 We -PRON- PRP cord-048446-gaemgm0t 150 2 see see VBP cord-048446-gaemgm0t 150 3 this this DT cord-048446-gaemgm0t 150 4 clearly clearly RB cord-048446-gaemgm0t 150 5 in in IN cord-048446-gaemgm0t 150 6 Boonah Boonah NNP cord-048446-gaemgm0t 150 7 , , , cord-048446-gaemgm0t 150 8 where where WRB cord-048446-gaemgm0t 150 9 it -PRON- PRP cord-048446-gaemgm0t 150 10 was be VBD cord-048446-gaemgm0t 150 11 acknowledged acknowledge VBN cord-048446-gaemgm0t 150 12 that that IN cord-048446-gaemgm0t 150 13 there there EX cord-048446-gaemgm0t 150 14 was be VBD cord-048446-gaemgm0t 150 15 underreporting underreporte VBG cord-048446-gaemgm0t 150 16 early early RB cord-048446-gaemgm0t 150 17 on on RB cord-048446-gaemgm0t 150 18 and and CC cord-048446-gaemgm0t 150 19 this this DT cord-048446-gaemgm0t 150 20 led lead VBD cord-048446-gaemgm0t 150 21 to to IN cord-048446-gaemgm0t 150 22 us -PRON- PRP cord-048446-gaemgm0t 150 23 getting get VBG cord-048446-gaemgm0t 150 24 very very RB cord-048446-gaemgm0t 150 25 high high JJ cord-048446-gaemgm0t 150 26 estimates estimate NNS cord-048446-gaemgm0t 150 27 for for IN cord-048446-gaemgm0t 150 28 the the DT cord-048446-gaemgm0t 150 29 initial initial JJ cord-048446-gaemgm0t 150 30 reproductive reproductive JJ cord-048446-gaemgm0t 150 31 number number NN cord-048446-gaemgm0t 150 32 . . . cord-048446-gaemgm0t 151 1 Similarly similarly RB cord-048446-gaemgm0t 151 2 , , , cord-048446-gaemgm0t 151 3 in in IN cord-048446-gaemgm0t 151 4 Cumberland Cumberland NNP cord-048446-gaemgm0t 151 5 , , , cord-048446-gaemgm0t 151 6 if if IN cord-048446-gaemgm0t 151 7 we -PRON- PRP cord-048446-gaemgm0t 151 8 remove remove VBP cord-048446-gaemgm0t 151 9 the the DT cord-048446-gaemgm0t 151 10 first first JJ cord-048446-gaemgm0t 151 11 five five CD cord-048446-gaemgm0t 151 12 days day NNS cord-048446-gaemgm0t 151 13 of of IN cord-048446-gaemgm0t 151 14 data datum NNS cord-048446-gaemgm0t 151 15 ( ( -LRB- cord-048446-gaemgm0t 151 16 three three CD cord-048446-gaemgm0t 151 17 cases case NNS cord-048446-gaemgm0t 151 18 on on IN cord-048446-gaemgm0t 151 19 the the DT cord-048446-gaemgm0t 151 20 first first JJ cord-048446-gaemgm0t 151 21 day day NN cord-048446-gaemgm0t 151 22 , , , cord-048446-gaemgm0t 151 23 six six CD cord-048446-gaemgm0t 151 24 cases case NNS cord-048446-gaemgm0t 151 25 on on IN cord-048446-gaemgm0t 151 26 the the DT cord-048446-gaemgm0t 151 27 second second JJ cord-048446-gaemgm0t 152 1 and and CC cord-048446-gaemgm0t 152 2 then then RB cord-048446-gaemgm0t 152 3 no no DT cord-048446-gaemgm0t 152 4 cases case NNS cord-048446-gaemgm0t 153 1 the the DT cord-048446-gaemgm0t 153 2 following follow VBG cord-048446-gaemgm0t 153 3 three three CD cord-048446-gaemgm0t 153 4 days day NNS cord-048446-gaemgm0t 153 5 ) ) -RRB- cord-048446-gaemgm0t 153 6 we -PRON- PRP cord-048446-gaemgm0t 153 7 get get VBP cord-048446-gaemgm0t 153 8 much much RB cord-048446-gaemgm0t 153 9 more more RBR cord-048446-gaemgm0t 153 10 reasonable reasonable JJ cord-048446-gaemgm0t 153 11 estimates estimate NNS cord-048446-gaemgm0t 153 12 ( ( -LRB- cord-048446-gaemgm0t 153 13 m~6:00,ŝ m~6:00,ŝ NNP cord-048446-gaemgm0t 153 14 2~1 2~1 CD cord-048446-gaemgm0t 153 15 0:32 0:32 CD cord-048446-gaemgm0t 153 16 ) ) -RRB- cord-048446-gaemgm0t 153 17 with with IN cord-048446-gaemgm0t 153 18 smaller small JJR cord-048446-gaemgm0t 153 19 residuals residual NNS cord-048446-gaemgm0t 153 20 ( ( -LRB- cord-048446-gaemgm0t 153 21 6.00 6.00 CD cord-048446-gaemgm0t 153 22 ) ) -RRB- cord-048446-gaemgm0t 153 23 . . . cord-048446-gaemgm0t 154 1 Therefore therefore RB cord-048446-gaemgm0t 154 2 , , , cord-048446-gaemgm0t 154 3 it -PRON- PRP cord-048446-gaemgm0t 154 4 is be VBZ cord-048446-gaemgm0t 154 5 important important JJ cord-048446-gaemgm0t 154 6 to to TO cord-048446-gaemgm0t 154 7 note note VB cord-048446-gaemgm0t 154 8 that that IN cord-048446-gaemgm0t 154 9 unusual unusual JJ cord-048446-gaemgm0t 154 10 observations observation NNS cord-048446-gaemgm0t 154 11 in in IN cord-048446-gaemgm0t 154 12 the the DT cord-048446-gaemgm0t 154 13 first first JJ cord-048446-gaemgm0t 154 14 few few JJ cord-048446-gaemgm0t 154 15 days day NNS cord-048446-gaemgm0t 154 16 can can MD cord-048446-gaemgm0t 154 17 impact impact VB cord-048446-gaemgm0t 154 18 the the DT cord-048446-gaemgm0t 154 19 estimates estimate NNS cord-048446-gaemgm0t 154 20 and and CC cord-048446-gaemgm0t 154 21 one one PRP cord-048446-gaemgm0t 154 22 should should MD cord-048446-gaemgm0t 154 23 pay pay VB cord-048446-gaemgm0t 154 24 careful careful JJ cord-048446-gaemgm0t 154 25 attention attention NN cord-048446-gaemgm0t 154 26 to to IN cord-048446-gaemgm0t 154 27 this this DT cord-048446-gaemgm0t 154 28 possibility possibility NN cord-048446-gaemgm0t 154 29 . . . cord-048446-gaemgm0t 155 1 Overall overall RB cord-048446-gaemgm0t 155 2 both both DT cord-048446-gaemgm0t 155 3 methodologies methodology NNS cord-048446-gaemgm0t 155 4 presented present VBN cord-048446-gaemgm0t 155 5 are be VBP cord-048446-gaemgm0t 155 6 valuable valuable JJ cord-048446-gaemgm0t 155 7 tools tool NNS cord-048446-gaemgm0t 155 8 that that WDT cord-048446-gaemgm0t 155 9 can can MD cord-048446-gaemgm0t 155 10 be be VB cord-048446-gaemgm0t 155 11 used use VBN cord-048446-gaemgm0t 155 12 in in IN cord-048446-gaemgm0t 155 13 tandem tandem NN cord-048446-gaemgm0t 155 14 for for IN cord-048446-gaemgm0t 155 15 understanding understand VBG cord-048446-gaemgm0t 155 16 the the DT cord-048446-gaemgm0t 155 17 dynamics dynamic NNS cord-048446-gaemgm0t 155 18 of of IN cord-048446-gaemgm0t 155 19 infectious infectious JJ cord-048446-gaemgm0t 155 20 disease disease NN cord-048446-gaemgm0t 155 21 epidemics epidemic NNS cord-048446-gaemgm0t 155 22 . . . cord-048446-gaemgm0t 156 1 These these DT cord-048446-gaemgm0t 156 2 methods method NNS cord-048446-gaemgm0t 156 3 are be VBP cord-048446-gaemgm0t 156 4 easy easy JJ cord-048446-gaemgm0t 156 5 to to TO cord-048446-gaemgm0t 156 6 implement implement VB cord-048446-gaemgm0t 156 7 and and CC cord-048446-gaemgm0t 156 8 interpret interpret VB cord-048446-gaemgm0t 156 9 . . . cord-048446-gaemgm0t 157 1 The the DT cord-048446-gaemgm0t 157 2 results result NNS cord-048446-gaemgm0t 157 3 that that WDT cord-048446-gaemgm0t 157 4 we -PRON- PRP cord-048446-gaemgm0t 157 5 have have VBP cord-048446-gaemgm0t 157 6 presented present VBN cord-048446-gaemgm0t 157 7 suggest suggest VBP cord-048446-gaemgm0t 157 8 that that IN cord-048446-gaemgm0t 157 9 the the DT cord-048446-gaemgm0t 157 10 average average JJ cord-048446-gaemgm0t 157 11 serial serial JJ cord-048446-gaemgm0t 157 12 interval interval NN cord-048446-gaemgm0t 157 13 for for IN cord-048446-gaemgm0t 157 14 pandemic pandemic NN cord-048446-gaemgm0t 157 15 influenza influenza NN cord-048446-gaemgm0t 157 16 in in IN cord-048446-gaemgm0t 157 17 1918 1918 CD cord-048446-gaemgm0t 157 18 was be VBD cord-048446-gaemgm0t 157 19 consistently consistently RB cord-048446-gaemgm0t 157 20 between between IN cord-048446-gaemgm0t 157 21 three three CD cord-048446-gaemgm0t 157 22 and and CC cord-048446-gaemgm0t 157 23 four four CD cord-048446-gaemgm0t 157 24 , , , cord-048446-gaemgm0t 157 25 regardless regardless RB cord-048446-gaemgm0t 157 26 of of IN cord-048446-gaemgm0t 157 27 the the DT cord-048446-gaemgm0t 157 28 setting setting NN cord-048446-gaemgm0t 157 29 . . . cord-048446-gaemgm0t 158 1 The the DT cord-048446-gaemgm0t 158 2 standard standard JJ cord-048446-gaemgm0t 158 3 deviation deviation NN cord-048446-gaemgm0t 158 4 for for IN cord-048446-gaemgm0t 158 5 the the DT cord-048446-gaemgm0t 158 6 serial serial JJ cord-048446-gaemgm0t 158 7 interval interval NN cord-048446-gaemgm0t 158 8 distribution distribution NN cord-048446-gaemgm0t 158 9 varied vary VBN cord-048446-gaemgm0t 158 10 much much RB cord-048446-gaemgm0t 158 11 more more JJR cord-048446-gaemgm0t 158 12 for for IN cord-048446-gaemgm0t 158 13 the the DT cord-048446-gaemgm0t 158 14 MLE MLE NNP cord-048446-gaemgm0t 158 15 method method NN cord-048446-gaemgm0t 158 16 depending depend VBG cord-048446-gaemgm0t 158 17 on on IN cord-048446-gaemgm0t 158 18 the the DT cord-048446-gaemgm0t 158 19 location location NN cord-048446-gaemgm0t 158 20 . . . cord-048446-gaemgm0t 159 1 Garske Garske NNP cord-048446-gaemgm0t 159 2 et et FW cord-048446-gaemgm0t 159 3 al al NNP cord-048446-gaemgm0t 159 4 . . . cord-048446-gaemgm0t 160 1 estimates estimate NNS cord-048446-gaemgm0t 160 2 indicate indicate VBP cord-048446-gaemgm0t 160 3 that that IN cord-048446-gaemgm0t 160 4 the the DT cord-048446-gaemgm0t 160 5 value value NN cord-048446-gaemgm0t 160 6 was be VBD cord-048446-gaemgm0t 160 7 consistently consistently RB cord-048446-gaemgm0t 160 8 smaller small JJR cord-048446-gaemgm0t 160 9 in in IN cord-048446-gaemgm0t 160 10 the the DT cord-048446-gaemgm0t 160 11 communities community NNS cord-048446-gaemgm0t 160 12 than than IN cord-048446-gaemgm0t 160 13 in in IN cord-048446-gaemgm0t 160 14 the the DT cord-048446-gaemgm0t 160 15 ships ship NNS cord-048446-gaemgm0t 160 16 . . . cord-048446-gaemgm0t 161 1 It -PRON- PRP cord-048446-gaemgm0t 161 2 is be VBZ cord-048446-gaemgm0t 161 3 not not RB cord-048446-gaemgm0t 161 4 clear clear JJ cord-048446-gaemgm0t 161 5 exactly exactly RB cord-048446-gaemgm0t 161 6 how how WRB cord-048446-gaemgm0t 161 7 to to TO cord-048446-gaemgm0t 161 8 interpret interpret VB cord-048446-gaemgm0t 161 9 this this DT cord-048446-gaemgm0t 161 10 result result NN cord-048446-gaemgm0t 161 11 . . . cord-048446-gaemgm0t 162 1 Further further RB cord-048446-gaemgm0t 162 2 , , , cord-048446-gaemgm0t 162 3 we -PRON- PRP cord-048446-gaemgm0t 162 4 consistently consistently RB cord-048446-gaemgm0t 162 5 see see VBP cord-048446-gaemgm0t 162 6 a a DT cord-048446-gaemgm0t 162 7 large large JJ cord-048446-gaemgm0t 162 8 initial initial JJ cord-048446-gaemgm0t 162 9 value value NN cord-048446-gaemgm0t 162 10 for for IN cord-048446-gaemgm0t 162 11 the the DT cord-048446-gaemgm0t 162 12 reproductive reproductive JJ cord-048446-gaemgm0t 162 13 number number NN cord-048446-gaemgm0t 162 14 . . . cord-048446-gaemgm0t 163 1 In in IN cord-048446-gaemgm0t 163 2 the the DT cord-048446-gaemgm0t 163 3 ships ship NNS cord-048446-gaemgm0t 163 4 , , , cord-048446-gaemgm0t 163 5 this this DT cord-048446-gaemgm0t 163 6 value value NN cord-048446-gaemgm0t 163 7 is be VBZ cord-048446-gaemgm0t 163 8 higher high JJR cord-048446-gaemgm0t 163 9 and and CC cord-048446-gaemgm0t 163 10 rapidly rapidly RB cord-048446-gaemgm0t 163 11 drops drop VBZ cord-048446-gaemgm0t 163 12 off off RP cord-048446-gaemgm0t 163 13 , , , cord-048446-gaemgm0t 163 14 perhaps perhaps RB cord-048446-gaemgm0t 163 15 due due IN cord-048446-gaemgm0t 163 16 to to IN cord-048446-gaemgm0t 163 17 the the DT cord-048446-gaemgm0t 163 18 close close JJ cord-048446-gaemgm0t 163 19 quarters quarter NNS cord-048446-gaemgm0t 163 20 and and CC cord-048446-gaemgm0t 163 21 extremely extremely RB cord-048446-gaemgm0t 163 22 rapid rapid JJ cord-048446-gaemgm0t 163 23 transmission transmission NN cord-048446-gaemgm0t 163 24 that that WDT cord-048446-gaemgm0t 163 25 could could MD cord-048446-gaemgm0t 163 26 take take VB cord-048446-gaemgm0t 163 27 place place NN cord-048446-gaemgm0t 163 28 in in IN cord-048446-gaemgm0t 163 29 these these DT cord-048446-gaemgm0t 163 30 very very RB cord-048446-gaemgm0t 163 31 vulnerable vulnerable JJ cord-048446-gaemgm0t 163 32 populations population NNS cord-048446-gaemgm0t 163 33 . . . cord-048446-gaemgm0t 164 1 In in IN cord-048446-gaemgm0t 164 2 the the DT cord-048446-gaemgm0t 164 3 communities community NNS cord-048446-gaemgm0t 164 4 , , , cord-048446-gaemgm0t 164 5 the the DT cord-048446-gaemgm0t 164 6 reproductive reproductive JJ cord-048446-gaemgm0t 164 7 number number NN cord-048446-gaemgm0t 164 8 tended tend VBD cord-048446-gaemgm0t 164 9 to to TO cord-048446-gaemgm0t 164 10 drop drop VB cord-048446-gaemgm0t 164 11 off off RP cord-048446-gaemgm0t 164 12 later later RB cord-048446-gaemgm0t 164 13 , , , cord-048446-gaemgm0t 164 14 typically typically RB cord-048446-gaemgm0t 164 15 around around IN cord-048446-gaemgm0t 164 16 day day NN cord-048446-gaemgm0t 164 17 thirty thirty CD cord-048446-gaemgm0t 164 18 . . . cord-048446-gaemgm0t 165 1 This this DT cord-048446-gaemgm0t 165 2 could could MD cord-048446-gaemgm0t 165 3 be be VB cord-048446-gaemgm0t 165 4 due due JJ cord-048446-gaemgm0t 165 5 to to IN cord-048446-gaemgm0t 165 6 a a DT cord-048446-gaemgm0t 165 7 larger large JJR cord-048446-gaemgm0t 165 8 initial initial JJ cord-048446-gaemgm0t 165 9 susceptible susceptible JJ cord-048446-gaemgm0t 165 10 population population NN cord-048446-gaemgm0t 165 11 and and CC cord-048446-gaemgm0t 165 12 more more RBR cord-048446-gaemgm0t 165 13 complicated complicated JJ cord-048446-gaemgm0t 165 14 dynamics dynamic NNS cord-048446-gaemgm0t 165 15 for for IN cord-048446-gaemgm0t 165 16 the the DT cord-048446-gaemgm0t 165 17 disease disease NN cord-048446-gaemgm0t 165 18 to to TO cord-048446-gaemgm0t 165 19 spread spread VB cord-048446-gaemgm0t 165 20 , , , cord-048446-gaemgm0t 165 21 leaving leave VBG cord-048446-gaemgm0t 165 22 large large JJ cord-048446-gaemgm0t 165 23 pockets pocket NNS cord-048446-gaemgm0t 165 24 of of IN cord-048446-gaemgm0t 165 25 susceptible susceptible JJ cord-048446-gaemgm0t 165 26 individuals individual NNS cord-048446-gaemgm0t 165 27 unexposed unexposed JJ cord-048446-gaemgm0t 165 28 for for IN cord-048446-gaemgm0t 165 29 a a DT cord-048446-gaemgm0t 165 30 longer long JJR cord-048446-gaemgm0t 165 31 period period NN cord-048446-gaemgm0t 165 32 of of IN cord-048446-gaemgm0t 165 33 time time NN cord-048446-gaemgm0t 165 34 than than IN cord-048446-gaemgm0t 165 35 in in IN cord-048446-gaemgm0t 165 36 the the DT cord-048446-gaemgm0t 165 37 ships ship NNS cord-048446-gaemgm0t 165 38 . . . cord-048446-gaemgm0t 165 39 _SP cord-048446-gaemgm0t 166 1 The the DT cord-048446-gaemgm0t 166 2 1918 1918 CD cord-048446-gaemgm0t 166 3 Influenza Influenza NNP cord-048446-gaemgm0t 166 4 Pandemic Pandemic NNP cord-048446-gaemgm0t 166 5 : : : cord-048446-gaemgm0t 166 6 Insights insight NNS cord-048446-gaemgm0t 166 7 for for IN cord-048446-gaemgm0t 166 8 the the DT cord-048446-gaemgm0t 166 9 21 21 CD cord-048446-gaemgm0t 166 10 st st NNP cord-048446-gaemgm0t 166 11 Century Century NNP cord-048446-gaemgm0t 166 12 Pandemic Pandemic NNP cord-048446-gaemgm0t 166 13 Influenza Influenza NNP cord-048446-gaemgm0t 166 14 : : : cord-048446-gaemgm0t 166 15 Past past NN cord-048446-gaemgm0t 166 16 , , , cord-048446-gaemgm0t 166 17 Present Present NNP cord-048446-gaemgm0t 166 18 and and CC cord-048446-gaemgm0t 166 19 Future future NN cord-048446-gaemgm0t 167 1 The the DT cord-048446-gaemgm0t 167 2 interval interval NN cord-048446-gaemgm0t 167 3 between between IN cord-048446-gaemgm0t 167 4 successive successive JJ cord-048446-gaemgm0t 167 5 cases case NNS cord-048446-gaemgm0t 167 6 of of IN cord-048446-gaemgm0t 167 7 an an DT cord-048446-gaemgm0t 167 8 infectious infectious JJ cord-048446-gaemgm0t 167 9 disease disease NN cord-048446-gaemgm0t 167 10 Infectious Infectious NNP cord-048446-gaemgm0t 167 11 Diseases disease NNS cord-048446-gaemgm0t 167 12 of of IN cord-048446-gaemgm0t 167 13 Humans Humans NNPS cord-048446-gaemgm0t 167 14 Definition Definition NNP cord-048446-gaemgm0t 167 15 and and CC cord-048446-gaemgm0t 167 16 estimation estimation NN cord-048446-gaemgm0t 167 17 of of IN cord-048446-gaemgm0t 167 18 an an DT cord-048446-gaemgm0t 167 19 actual actual JJ cord-048446-gaemgm0t 167 20 reproduction reproduction NN cord-048446-gaemgm0t 167 21 number number NN cord-048446-gaemgm0t 167 22 describing describe VBG cord-048446-gaemgm0t 167 23 past past IN cord-048446-gaemgm0t 167 24 infectious infectious JJ cord-048446-gaemgm0t 167 25 disease disease NN cord-048446-gaemgm0t 167 26 transmission transmission NN cord-048446-gaemgm0t 167 27 : : : cord-048446-gaemgm0t 167 28 application application NN cord-048446-gaemgm0t 167 29 to to IN cord-048446-gaemgm0t 167 30 HIV HIV NNP cord-048446-gaemgm0t 167 31 epidemics epidemic NNS cord-048446-gaemgm0t 167 32 among among IN cord-048446-gaemgm0t 167 33 homosexual homosexual JJ cord-048446-gaemgm0t 167 34 men man NNS cord-048446-gaemgm0t 167 35 in in IN cord-048446-gaemgm0t 167 36 Denmark Denmark NNP cord-048446-gaemgm0t 167 37 Herd Herd NNP cord-048446-gaemgm0t 167 38 immunity immunity NN cord-048446-gaemgm0t 167 39 and and CC cord-048446-gaemgm0t 167 40 herd herd NN cord-048446-gaemgm0t 167 41 effect effect NN cord-048446-gaemgm0t 167 42 : : : cord-048446-gaemgm0t 167 43 new new JJ cord-048446-gaemgm0t 167 44 insights insight NNS cord-048446-gaemgm0t 167 45 and and CC cord-048446-gaemgm0t 167 46 definitions definition NNS cord-048446-gaemgm0t 168 1 Different different JJ cord-048446-gaemgm0t 168 2 Epidemic epidemic NN cord-048446-gaemgm0t 168 3 Curves curve NNS cord-048446-gaemgm0t 168 4 for for IN cord-048446-gaemgm0t 168 5 Severe severe JJ cord-048446-gaemgm0t 168 6 Acute acute JJ cord-048446-gaemgm0t 168 7 Respiratory Respiratory NNP cord-048446-gaemgm0t 168 8 Syndrome Syndrome NNP cord-048446-gaemgm0t 168 9 Reveal reveal VBP cord-048446-gaemgm0t 168 10 Similar similar JJ cord-048446-gaemgm0t 168 11 Impacts impact NNS cord-048446-gaemgm0t 168 12 of of IN cord-048446-gaemgm0t 168 13 Control Control NNP cord-048446-gaemgm0t 168 14 Measures Measures NNPS cord-048446-gaemgm0t 169 1 A a DT cord-048446-gaemgm0t 169 2 note note NN cord-048446-gaemgm0t 169 3 on on IN cord-048446-gaemgm0t 169 4 generation generation NN cord-048446-gaemgm0t 169 5 times time NNS cord-048446-gaemgm0t 169 6 in in IN cord-048446-gaemgm0t 169 7 epidemic epidemic NN cord-048446-gaemgm0t 169 8 models model NNS cord-048446-gaemgm0t 169 9 Transmission Transmission NNP cord-048446-gaemgm0t 169 10 Dynamics Dynamics NNPS cord-048446-gaemgm0t 169 11 and and CC cord-048446-gaemgm0t 169 12 Control Control NNP cord-048446-gaemgm0t 169 13 of of IN cord-048446-gaemgm0t 169 14 Severe Severe NNP cord-048446-gaemgm0t 169 15 Acute acute JJ cord-048446-gaemgm0t 169 16 Respiratory Respiratory NNP cord-048446-gaemgm0t 169 17 Syndrome Syndrome NNP cord-048446-gaemgm0t 169 18 Estimating Estimating NNP cord-048446-gaemgm0t 169 19 Individual Individual NNP cord-048446-gaemgm0t 169 20 and and CC cord-048446-gaemgm0t 169 21 Household Household NNP cord-048446-gaemgm0t 169 22 Reproduction Reproduction NNP cord-048446-gaemgm0t 169 23 Numbers Numbers NNPS cord-048446-gaemgm0t 169 24 in in IN cord-048446-gaemgm0t 169 25 an an DT cord-048446-gaemgm0t 169 26 Emerging Emerging NNP cord-048446-gaemgm0t 169 27 Epidemic epidemic NN cord-048446-gaemgm0t 169 28 Estimation estimation NN cord-048446-gaemgm0t 169 29 in in IN cord-048446-gaemgm0t 169 30 real real JJ cord-048446-gaemgm0t 169 31 time time NN cord-048446-gaemgm0t 169 32 the the DT cord-048446-gaemgm0t 169 33 efficacy efficacy NN cord-048446-gaemgm0t 169 34 of of IN cord-048446-gaemgm0t 169 35 measures measure NNS cord-048446-gaemgm0t 169 36 to to TO cord-048446-gaemgm0t 169 37 control control VB cord-048446-gaemgm0t 169 38 emerging emerge VBG cord-048446-gaemgm0t 169 39 communicable communicable JJ cord-048446-gaemgm0t 169 40 diseases disease NNS cord-048446-gaemgm0t 170 1 The the DT cord-048446-gaemgm0t 170 2 Transmissibility Transmissibility NNP cord-048446-gaemgm0t 170 3 of of IN cord-048446-gaemgm0t 170 4 Highly highly RB cord-048446-gaemgm0t 170 5 Pathogenic pathogenic JJ cord-048446-gaemgm0t 170 6 Avian Avian NNP cord-048446-gaemgm0t 170 7 Influenza Influenza NNP cord-048446-gaemgm0t 170 8 in in IN cord-048446-gaemgm0t 170 9 Commercial Commercial NNP cord-048446-gaemgm0t 170 10 Poultry Poultry NNP cord-048446-gaemgm0t 170 11 in in IN cord-048446-gaemgm0t 170 12 Industrialized Industrialized NNP cord-048446-gaemgm0t 170 13 Countries Countries NNPS cord-048446-gaemgm0t 170 14 Transmissibility Transmissibility NNP cord-048446-gaemgm0t 170 15 of of IN cord-048446-gaemgm0t 170 16 1918 1918 CD cord-048446-gaemgm0t 170 17 pandemic pandemic NN cord-048446-gaemgm0t 170 18 influenza influenza NN cord-048446-gaemgm0t 170 19 Transmission transmission NN cord-048446-gaemgm0t 170 20 dynamics dynamic NNS cord-048446-gaemgm0t 170 21 of of IN cord-048446-gaemgm0t 170 22 the the DT cord-048446-gaemgm0t 170 23 great great JJ cord-048446-gaemgm0t 170 24 influenza influenza NN cord-048446-gaemgm0t 170 25 pandemic pandemic NN cord-048446-gaemgm0t 170 26 of of IN cord-048446-gaemgm0t 170 27 Estimates estimate NNS cord-048446-gaemgm0t 170 28 of of IN cord-048446-gaemgm0t 170 29 the the DT cord-048446-gaemgm0t 170 30 reproduction reproduction NN cord-048446-gaemgm0t 170 31 numbers number NNS cord-048446-gaemgm0t 170 32 of of IN cord-048446-gaemgm0t 170 33 Spanish spanish JJ cord-048446-gaemgm0t 170 34 influenza influenza NN cord-048446-gaemgm0t 170 35 using use VBG cord-048446-gaemgm0t 170 36 morbidity morbidity NN cord-048446-gaemgm0t 170 37 data datum NNS cord-048446-gaemgm0t 171 1 An an DT cord-048446-gaemgm0t 171 2 influenza influenza NN cord-048446-gaemgm0t 171 3 simulation simulation NN cord-048446-gaemgm0t 171 4 model model NN cord-048446-gaemgm0t 171 5 for for IN cord-048446-gaemgm0t 171 6 immunization immunization NN cord-048446-gaemgm0t 171 7 studies study NNS cord-048446-gaemgm0t 171 8 Community Community NNP cord-048446-gaemgm0t 171 9 trials trial NNS cord-048446-gaemgm0t 171 10 of of IN cord-048446-gaemgm0t 171 11 vaccination vaccination NN cord-048446-gaemgm0t 171 12 and and CC cord-048446-gaemgm0t 171 13 the the DT cord-048446-gaemgm0t 171 14 epidemic epidemic NN cord-048446-gaemgm0t 171 15 prevention prevention NN cord-048446-gaemgm0t 171 16 potential potential NN cord-048446-gaemgm0t 171 17 Containing contain VBG cord-048446-gaemgm0t 171 18 pandemic pandemic NN cord-048446-gaemgm0t 171 19 influenza influenza NN cord-048446-gaemgm0t 171 20 with with IN cord-048446-gaemgm0t 171 21 antiviral antiviral JJ cord-048446-gaemgm0t 171 22 agents agent NNS cord-048446-gaemgm0t 171 23 Influenza Influenza NNP cord-048446-gaemgm0t 171 24 in in IN cord-048446-gaemgm0t 171 25 Maryland Maryland NNP cord-048446-gaemgm0t 171 26 . . . cord-048446-gaemgm0t 172 1 Preliminary preliminary JJ cord-048446-gaemgm0t 172 2 statistics statistic NNS cord-048446-gaemgm0t 172 3 of of IN cord-048446-gaemgm0t 172 4 certain certain JJ cord-048446-gaemgm0t 172 5 locations location NNS cord-048446-gaemgm0t 173 1 A a DT cord-048446-gaemgm0t 173 2 likelihood likelihood NN cord-048446-gaemgm0t 173 3 based base VBN cord-048446-gaemgm0t 173 4 method method NN cord-048446-gaemgm0t 173 5 for for IN cord-048446-gaemgm0t 173 6 real real JJ cord-048446-gaemgm0t 173 7 time time NN cord-048446-gaemgm0t 173 8 estimation estimation NN cord-048446-gaemgm0t 173 9 of of IN cord-048446-gaemgm0t 173 10 the the DT cord-048446-gaemgm0t 173 11 serial serial JJ cord-048446-gaemgm0t 173 12 interval interval NN cord-048446-gaemgm0t 173 13 and and CC cord-048446-gaemgm0t 173 14 reproductive reproductive JJ cord-048446-gaemgm0t 173 15 number number NN cord-048446-gaemgm0t 173 16 of of IN cord-048446-gaemgm0t 173 17 an an DT cord-048446-gaemgm0t 173 18 epidemic epidemic NN cord-048446-gaemgm0t 174 1 A a DT cord-048446-gaemgm0t 174 2 flexible flexible JJ cord-048446-gaemgm0t 174 3 growth growth NN cord-048446-gaemgm0t 174 4 function function NN cord-048446-gaemgm0t 174 5 for for IN cord-048446-gaemgm0t 174 6 empirical empirical JJ cord-048446-gaemgm0t 174 7 use use NN cord-048446-gaemgm0t 174 8 Radioligand Radioligand NNP cord-048446-gaemgm0t 174 9 Assay Assay NNP cord-048446-gaemgm0t 174 10 Statistical Statistical NNP cord-048446-gaemgm0t 174 11 analysis analysis NN cord-048446-gaemgm0t 174 12 of of IN cord-048446-gaemgm0t 174 13 radioimmunoassay radioimmunoassay JJ cord-048446-gaemgm0t 174 14 data datum NNS cord-048446-gaemgm0t 175 1 These these DT cord-048446-gaemgm0t 175 2 results result NNS cord-048446-gaemgm0t 175 3 confirm confirm VBP cord-048446-gaemgm0t 175 4 the the DT cord-048446-gaemgm0t 175 5 high high JJ cord-048446-gaemgm0t 175 6 pathogenicity pathogenicity NN cord-048446-gaemgm0t 175 7 of of IN cord-048446-gaemgm0t 175 8 influenza influenza NN cord-048446-gaemgm0t 175 9 and and CC cord-048446-gaemgm0t 175 10 its -PRON- PRP$ cord-048446-gaemgm0t 175 11 ability ability NN cord-048446-gaemgm0t 175 12 to to TO cord-048446-gaemgm0t 175 13 rapidly rapidly RB cord-048446-gaemgm0t 175 14 spread spread VB cord-048446-gaemgm0t 175 15 through through IN cord-048446-gaemgm0t 175 16 populations population NNS cord-048446-gaemgm0t 175 17 . . . cord-048446-gaemgm0t 176 1 It -PRON- PRP cord-048446-gaemgm0t 176 2 also also RB cord-048446-gaemgm0t 176 3 appears appear VBZ cord-048446-gaemgm0t 176 4 that that IN cord-048446-gaemgm0t 176 5 the the DT cord-048446-gaemgm0t 176 6 greatest great JJS cord-048446-gaemgm0t 176 7 difference difference NN cord-048446-gaemgm0t 176 8 between between IN cord-048446-gaemgm0t 176 9 the the DT cord-048446-gaemgm0t 176 10 spread spread NN cord-048446-gaemgm0t 176 11 of of IN cord-048446-gaemgm0t 176 12 influenza influenza NN cord-048446-gaemgm0t 176 13 in in IN cord-048446-gaemgm0t 176 14 a a DT cord-048446-gaemgm0t 176 15 closed closed JJ cord-048446-gaemgm0t 176 16 population population NN cord-048446-gaemgm0t 176 17 without without IN cord-048446-gaemgm0t 176 18 the the DT cord-048446-gaemgm0t 176 19 ability ability NN cord-048446-gaemgm0t 176 20 to to TO cord-048446-gaemgm0t 176 21 implement implement VB cord-048446-gaemgm0t 176 22 control control NN cord-048446-gaemgm0t 176 23 measures measure NNS cord-048446-gaemgm0t 176 24 is be VBZ cord-048446-gaemgm0t 176 25 a a DT cord-048446-gaemgm0t 176 26 large large JJ cord-048446-gaemgm0t 176 27 initial initial JJ cord-048446-gaemgm0t 176 28 reproductive reproductive JJ cord-048446-gaemgm0t 176 29 number number NN cord-048446-gaemgm0t 176 30 that that WDT cord-048446-gaemgm0t 176 31 declines decline VBZ cord-048446-gaemgm0t 176 32 rapidly rapidly RB cord-048446-gaemgm0t 176 33 . . . cord-048446-gaemgm0t 177 1 In in IN cord-048446-gaemgm0t 177 2 more more RBR cord-048446-gaemgm0t 177 3 diffuse diffuse JJ cord-048446-gaemgm0t 177 4 communities community NNS cord-048446-gaemgm0t 177 5 with with IN cord-048446-gaemgm0t 177 6 complicated complicated JJ cord-048446-gaemgm0t 177 7 dynamics dynamic NNS cord-048446-gaemgm0t 177 8 , , , cord-048446-gaemgm0t 177 9 it -PRON- PRP cord-048446-gaemgm0t 177 10 is be VBZ cord-048446-gaemgm0t 177 11 likely likely JJ cord-048446-gaemgm0t 177 12 that that IN cord-048446-gaemgm0t 177 13 the the DT cord-048446-gaemgm0t 177 14 reproductive reproductive JJ cord-048446-gaemgm0t 177 15 number number NN cord-048446-gaemgm0t 177 16 will will MD cord-048446-gaemgm0t 177 17 not not RB cord-048446-gaemgm0t 177 18 decline decline VB cord-048446-gaemgm0t 177 19 as as RB cord-048446-gaemgm0t 177 20 rapidly rapidly RB cord-048446-gaemgm0t 177 21 . . . cord-048446-gaemgm0t 178 1 Conceived conceive VBN cord-048446-gaemgm0t 178 2 and and CC cord-048446-gaemgm0t 178 3 designed design VBD cord-048446-gaemgm0t 178 4 the the DT cord-048446-gaemgm0t 178 5 experiments experiment NNS cord-048446-gaemgm0t 178 6 : : : cord-048446-gaemgm0t 178 7 LW LW NNP cord-048446-gaemgm0t 178 8 MP MP NNP cord-048446-gaemgm0t 178 9 . . . cord-048446-gaemgm0t 179 1 Performed perform VBN cord-048446-gaemgm0t 179 2 the the DT cord-048446-gaemgm0t 179 3 experiments experiment NNS cord-048446-gaemgm0t 179 4 : : : cord-048446-gaemgm0t 179 5 LW lw NN cord-048446-gaemgm0t 179 6 . . . cord-048446-gaemgm0t 180 1 Analyzed analyze VBD cord-048446-gaemgm0t 180 2 the the DT cord-048446-gaemgm0t 180 3 data datum NNS cord-048446-gaemgm0t 180 4 : : : cord-048446-gaemgm0t 180 5 LW lw NN cord-048446-gaemgm0t 180 6 . . . cord-048446-gaemgm0t 181 1 Wrote write VBD cord-048446-gaemgm0t 181 2 the the DT cord-048446-gaemgm0t 181 3 paper paper NN cord-048446-gaemgm0t 181 4 : : : cord-048446-gaemgm0t 181 5 LW lw NN cord-048446-gaemgm0t 181 6 . . .