id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-265139-x7g3jcjm	Zaiou, Mohamed	The Emerging Role and Promise of Circular RNAs in Obesity and Related Metabolic Disorders	2020-06-16		.txt	text/plain	8180	440	41	There is also growing evidence that circRNAs are closely linked to non-alcoholic fatty liver disease (NAFLD), a disorder that is caused by a plethora of factors including hepatic lipid accumulation, adipose tissue and mitochondrial dysfunction, a high-fat diet, obesity, a chronic inflammatory state, insulin resistance (IR), and genetic and epigenetic factors [48, 55] . In addition to classical epigenetic modifications, a variety of ncRNAs have been uncovered in different cells and organs including adipose tissues, many of which are involved in the regulation of adipogenesis and other metabolic processes implying their role in the etiology of obesity [69] . Emerging evidence from in vitro and in vivo animal studies suggest that circRNAs are expressed in adipose tissues and may modulate adipogenesis and lipid metabolism. Collectively, the results from the above studies demonstrate that several circRNAs are differentially expressed in adipose tissue and support a significant role of these RNA species in the regulatory networks of adipogenesis.	./cache/cord-265139-x7g3jcjm.txt	./txt/cord-265139-x7g3jcjm.txt