id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-311535-ppkwd1kp	Korakas, Emmanouil	Obesity and COVID-19: immune and metabolic derangement as a possible link to adverse clinical outcomes	2020-07-01		.txt	text/plain	2778	124	36	The production of increased amounts of cytokines such as TNFα, IL-1, IL-6, and monocyte chemoattractant protein (MCP-1) lead to oxidative stress and defective function of innate and adaptive immunity, whereas the activation of NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome seems to play a crucial role in the pathogenesis of the infection. Endothelial dysfunction and arterial stiffness could favor the recently discovered infection of the endothelium by SARS-CoV-2, whereas alterations in cardiac structure and function and the prothrombotic microenvironment in obesity could provide a link for the increased cardiovascular events in these patients. Chronic inflammation and oxidative stress, hypercytokinemia, immune dysregulation, endothelial dysfunction, and cardiovascular abnormalities are all possible mechanisms through which the excess in adipose tissue could lead to the acute hyperinflammatory state that characterizes severe SARS-CoV-2 infections and is responsible for its complications.	./cache/cord-311535-ppkwd1kp.txt	./txt/cord-311535-ppkwd1kp.txt