id author title date pages extension mime words sentences flesch summary cache txt cord-333368-kjrk8nn9 Huizinga, Gabrielle P The Collision of Meta-Inflammation and SARS-CoV-2 Pandemic Infection 2020-09-03 .txt text/plain 5490 347 47 While obesity and diabetes may complicate the delivery of supportive care in critical illness regardless of the underlying disease, lessons learned from the interaction of obesity with other systemic inflammatory syndromes suggest that obesity modifies biologic factors related to SARS-CoV-2 infection and the COVID-19 syndrome. In seasonal and pandemic influenza, however, obese individuals may be more susceptible to severe viral respiratory disease even if they mount a serologic response to vaccination 25 A c c e p t e d M a n u s c r i p t 11 Along with possible impairments in pathogen clearance, obese hosts are more likely to experience the breakdown of respiratory epithelium during a pulmonary infection, which leads to increased fluid in the airway space. ./cache/cord-333368-kjrk8nn9.txt ./txt/cord-333368-kjrk8nn9.txt