id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-338317-ro041w5l	Lockhart, Sam M.	When two pandemics meet: Why is obesity associated with increased COVID-19 mortality?	2020-06-29		.txt	text/plain	4664	247	47	Thus, the association of obesity with worse 105 outcomes in acute lung infection or widespread alveolar damage of other types, appears to be 106 strongest and most consistent with COVID-19 and pandemic H1N1 influenza. In addition to being lower in obesity and most insulin 168 resistant states it is worth noting that adiponectin levels have been reported to be significantly 169 lower in many of the COVID-19 "at risk" groups e.g. Male < Females 20 and South Asians < White 170 is secreted from adipose tissue, associated with insulin resistance and likely contributes to 197 thrombotic risk in obesity by impairing fibrinolysis 23 . In summary, we have applied insights into the pathophysiology of the adverse consequences of 279 obesity and emerging evidence regarding the pathological mechanisms in COVID-19 to suggest 280 possible routes whereby obesity can exacerbate the tissue damage associated with infection by the 281 SARS-CoV-2 virus.	./cache/cord-338317-ro041w5l.txt	./txt/cord-338317-ro041w5l.txt