id sid tid token lemma pos cord-265139-x7g3jcjm 1 1 key key NN cord-265139-x7g3jcjm 1 2 : : : cord-265139-x7g3jcjm 1 3 cord-265139-x7g3jcjm cord-265139-x7g3jcjm CD cord-265139-x7g3jcjm 1 4 authors author NNS cord-265139-x7g3jcjm 1 5 : : : cord-265139-x7g3jcjm 2 1 Zaiou Zaiou NNP cord-265139-x7g3jcjm 3 1 , , , cord-265139-x7g3jcjm 3 2 Mohamed Mohamed NNP cord-265139-x7g3jcjm 3 3 title title NN cord-265139-x7g3jcjm 3 4 : : : cord-265139-x7g3jcjm 3 5 The the DT cord-265139-x7g3jcjm 3 6 Emerging emerge VBG cord-265139-x7g3jcjm 3 7 Role role NN cord-265139-x7g3jcjm 3 8 and and CC cord-265139-x7g3jcjm 3 9 Promise Promise NNP cord-265139-x7g3jcjm 3 10 of of IN cord-265139-x7g3jcjm 3 11 Circular circular JJ cord-265139-x7g3jcjm 3 12 RNAs rna NNS cord-265139-x7g3jcjm 3 13 in in IN cord-265139-x7g3jcjm 3 14 Obesity obesity NN cord-265139-x7g3jcjm 3 15 and and CC cord-265139-x7g3jcjm 3 16 Related related JJ cord-265139-x7g3jcjm 3 17 Metabolic metabolic JJ cord-265139-x7g3jcjm 3 18 Disorders Disorders NNPS cord-265139-x7g3jcjm 3 19 date date NN cord-265139-x7g3jcjm 3 20 : : : cord-265139-x7g3jcjm 3 21 2020 2020 CD cord-265139-x7g3jcjm 3 22 - - HYPH cord-265139-x7g3jcjm 3 23 06 06 CD cord-265139-x7g3jcjm 3 24 - - SYM cord-265139-x7g3jcjm 3 25 16 16 CD cord-265139-x7g3jcjm 3 26 journal journal NN cord-265139-x7g3jcjm 3 27 : : : cord-265139-x7g3jcjm 4 1 Cells cell NNS cord-265139-x7g3jcjm 4 2 DOI DOI NNP cord-265139-x7g3jcjm 4 3 : : : cord-265139-x7g3jcjm 5 1 10.3390 10.3390 CD cord-265139-x7g3jcjm 5 2 / / SYM cord-265139-x7g3jcjm 5 3 cells9061473 cells9061473 NNP cord-265139-x7g3jcjm 5 4 sha sha NNP cord-265139-x7g3jcjm 5 5 : : : cord-265139-x7g3jcjm 6 1 c2605ddae1688b39797a8ed57c6a961547c91478 c2605ddae1688b39797a8ed57c6a961547c91478 NNP cord-265139-x7g3jcjm 6 2 doc_id doc_id CD cord-265139-x7g3jcjm 6 3 : : : cord-265139-x7g3jcjm 6 4 265139 265139 CD cord-265139-x7g3jcjm 6 5 cord_uid cord_uid NNS cord-265139-x7g3jcjm 6 6 : : : cord-265139-x7g3jcjm 7 1 x7g3jcjm x7g3jcjm JJ cord-265139-x7g3jcjm 7 2 Circular circular JJ cord-265139-x7g3jcjm 7 3 RNAs rna NNS cord-265139-x7g3jcjm 7 4 ( ( -LRB- cord-265139-x7g3jcjm 7 5 circRNAs circRNAs NNP cord-265139-x7g3jcjm 7 6 ) ) -RRB- cord-265139-x7g3jcjm 7 7 are be VBP cord-265139-x7g3jcjm 7 8 genome genome NN cord-265139-x7g3jcjm 7 9 transcripts transcript NNS cord-265139-x7g3jcjm 7 10 that that WDT cord-265139-x7g3jcjm 7 11 are be VBP cord-265139-x7g3jcjm 7 12 produced produce VBN cord-265139-x7g3jcjm 7 13 from from IN cord-265139-x7g3jcjm 7 14 back back NN cord-265139-x7g3jcjm 7 15 - - HYPH cord-265139-x7g3jcjm 7 16 splicing splicing NN cord-265139-x7g3jcjm 7 17 of of IN cord-265139-x7g3jcjm 7 18 specific specific JJ cord-265139-x7g3jcjm 7 19 regions region NNS cord-265139-x7g3jcjm 7 20 of of IN cord-265139-x7g3jcjm 7 21 pre pre JJ cord-265139-x7g3jcjm 7 22 - - NN cord-265139-x7g3jcjm 7 23 mRNA mrna NN cord-265139-x7g3jcjm 7 24 . . . cord-265139-x7g3jcjm 8 1 These these DT cord-265139-x7g3jcjm 8 2 single single RB cord-265139-x7g3jcjm 8 3 - - HYPH cord-265139-x7g3jcjm 8 4 stranded strand VBN cord-265139-x7g3jcjm 8 5 RNA RNA NNP cord-265139-x7g3jcjm 8 6 molecules molecule NNS cord-265139-x7g3jcjm 8 7 are be VBP cord-265139-x7g3jcjm 8 8 widely widely RB cord-265139-x7g3jcjm 8 9 expressed express VBN cord-265139-x7g3jcjm 8 10 across across IN cord-265139-x7g3jcjm 8 11 diverse diverse JJ cord-265139-x7g3jcjm 8 12 phyla phylum NNS cord-265139-x7g3jcjm 8 13 and and CC cord-265139-x7g3jcjm 8 14 many many JJ cord-265139-x7g3jcjm 8 15 of of IN cord-265139-x7g3jcjm 8 16 them -PRON- PRP cord-265139-x7g3jcjm 8 17 are be VBP cord-265139-x7g3jcjm 8 18 stable stable JJ cord-265139-x7g3jcjm 8 19 and and CC cord-265139-x7g3jcjm 8 20 evolutionary evolutionary JJ cord-265139-x7g3jcjm 8 21 conserved conserve VBN cord-265139-x7g3jcjm 8 22 between between IN cord-265139-x7g3jcjm 8 23 species specie NNS cord-265139-x7g3jcjm 8 24 . . . cord-265139-x7g3jcjm 9 1 Growing grow VBG cord-265139-x7g3jcjm 9 2 evidence evidence NN cord-265139-x7g3jcjm 9 3 suggests suggest VBZ cord-265139-x7g3jcjm 9 4 that that IN cord-265139-x7g3jcjm 9 5 many many JJ cord-265139-x7g3jcjm 9 6 circRNAs circrna NNS cord-265139-x7g3jcjm 9 7 function function NN cord-265139-x7g3jcjm 9 8 as as IN cord-265139-x7g3jcjm 9 9 master master NN cord-265139-x7g3jcjm 9 10 regulators regulator NNS cord-265139-x7g3jcjm 9 11 of of IN cord-265139-x7g3jcjm 9 12 gene gene NN cord-265139-x7g3jcjm 9 13 expression expression NN cord-265139-x7g3jcjm 9 14 by by IN cord-265139-x7g3jcjm 9 15 influencing influence VBG cord-265139-x7g3jcjm 9 16 both both CC cord-265139-x7g3jcjm 9 17 transcription transcription NN cord-265139-x7g3jcjm 9 18 and and CC cord-265139-x7g3jcjm 9 19 translation translation NN cord-265139-x7g3jcjm 9 20 processes process NNS cord-265139-x7g3jcjm 9 21 . . . cord-265139-x7g3jcjm 10 1 Mechanistically mechanistically RB cord-265139-x7g3jcjm 10 2 , , , cord-265139-x7g3jcjm 10 3 circRNAs circrna NNS cord-265139-x7g3jcjm 10 4 are be VBP cord-265139-x7g3jcjm 10 5 predicted predict VBN cord-265139-x7g3jcjm 10 6 to to TO cord-265139-x7g3jcjm 10 7 act act VB cord-265139-x7g3jcjm 10 8 as as IN cord-265139-x7g3jcjm 10 9 endogenous endogenous JJ cord-265139-x7g3jcjm 10 10 microRNA microRNA NNP cord-265139-x7g3jcjm 10 11 ( ( -LRB- cord-265139-x7g3jcjm 10 12 miRNA miRNA NNP cord-265139-x7g3jcjm 10 13 ) ) -RRB- cord-265139-x7g3jcjm 10 14 sponges sponge NNS cord-265139-x7g3jcjm 10 15 , , , cord-265139-x7g3jcjm 10 16 interact interact VB cord-265139-x7g3jcjm 10 17 with with IN cord-265139-x7g3jcjm 10 18 functional functional JJ cord-265139-x7g3jcjm 10 19 RNA RNA NNP cord-265139-x7g3jcjm 10 20 - - HYPH cord-265139-x7g3jcjm 10 21 binding bind VBG cord-265139-x7g3jcjm 10 22 proteins protein NNS cord-265139-x7g3jcjm 10 23 ( ( -LRB- cord-265139-x7g3jcjm 10 24 RBPs RBPs NNP cord-265139-x7g3jcjm 10 25 ) ) -RRB- cord-265139-x7g3jcjm 10 26 , , , cord-265139-x7g3jcjm 10 27 and and CC cord-265139-x7g3jcjm 10 28 associate associate VB cord-265139-x7g3jcjm 10 29 with with IN cord-265139-x7g3jcjm 10 30 elements element NNS cord-265139-x7g3jcjm 10 31 of of IN cord-265139-x7g3jcjm 10 32 the the DT cord-265139-x7g3jcjm 10 33 transcriptional transcriptional JJ cord-265139-x7g3jcjm 10 34 machinery machinery NN cord-265139-x7g3jcjm 10 35 in in IN cord-265139-x7g3jcjm 10 36 the the DT cord-265139-x7g3jcjm 10 37 nucleus nucleus NN cord-265139-x7g3jcjm 10 38 . . . cord-265139-x7g3jcjm 11 1 Evidence evidence NN cord-265139-x7g3jcjm 11 2 is be VBZ cord-265139-x7g3jcjm 11 3 mounting mount VBG cord-265139-x7g3jcjm 11 4 that that DT cord-265139-x7g3jcjm 11 5 dysregulation dysregulation NN cord-265139-x7g3jcjm 11 6 of of IN cord-265139-x7g3jcjm 11 7 circRNAs circrna NNS cord-265139-x7g3jcjm 11 8 is be VBZ cord-265139-x7g3jcjm 11 9 closely closely RB cord-265139-x7g3jcjm 11 10 related related JJ cord-265139-x7g3jcjm 11 11 to to IN cord-265139-x7g3jcjm 11 12 the the DT cord-265139-x7g3jcjm 11 13 occurrence occurrence NN cord-265139-x7g3jcjm 11 14 of of IN cord-265139-x7g3jcjm 11 15 a a DT cord-265139-x7g3jcjm 11 16 range range NN cord-265139-x7g3jcjm 11 17 of of IN cord-265139-x7g3jcjm 11 18 diseases disease NNS cord-265139-x7g3jcjm 11 19 including include VBG cord-265139-x7g3jcjm 11 20 cancer cancer NN cord-265139-x7g3jcjm 11 21 and and CC cord-265139-x7g3jcjm 11 22 metabolic metabolic JJ cord-265139-x7g3jcjm 11 23 diseases disease NNS cord-265139-x7g3jcjm 11 24 . . . cord-265139-x7g3jcjm 12 1 Indeed indeed RB cord-265139-x7g3jcjm 12 2 , , , cord-265139-x7g3jcjm 12 3 there there EX cord-265139-x7g3jcjm 12 4 are be VBP cord-265139-x7g3jcjm 12 5 several several JJ cord-265139-x7g3jcjm 12 6 reports report NNS cord-265139-x7g3jcjm 12 7 implicating implicate VBG cord-265139-x7g3jcjm 12 8 circRNAs circrna NNS cord-265139-x7g3jcjm 12 9 in in IN cord-265139-x7g3jcjm 12 10 cardiovascular cardiovascular JJ cord-265139-x7g3jcjm 12 11 diseases disease NNS cord-265139-x7g3jcjm 12 12 ( ( -LRB- cord-265139-x7g3jcjm 12 13 CVD CVD NNP cord-265139-x7g3jcjm 12 14 ) ) -RRB- cord-265139-x7g3jcjm 12 15 , , , cord-265139-x7g3jcjm 12 16 diabetes diabetes NN cord-265139-x7g3jcjm 12 17 , , , cord-265139-x7g3jcjm 12 18 hypertension hypertension NN cord-265139-x7g3jcjm 12 19 , , , cord-265139-x7g3jcjm 12 20 and and CC cord-265139-x7g3jcjm 12 21 atherosclerosis atherosclerosis NN cord-265139-x7g3jcjm 12 22 . . . cord-265139-x7g3jcjm 13 1 However however RB cord-265139-x7g3jcjm 13 2 , , , cord-265139-x7g3jcjm 13 3 there there EX cord-265139-x7g3jcjm 13 4 is be VBZ cord-265139-x7g3jcjm 13 5 very very RB cord-265139-x7g3jcjm 13 6 little little JJ cord-265139-x7g3jcjm 13 7 research research NN cord-265139-x7g3jcjm 13 8 addressing address VBG cord-265139-x7g3jcjm 13 9 the the DT cord-265139-x7g3jcjm 13 10 potential potential JJ cord-265139-x7g3jcjm 13 11 role role NN cord-265139-x7g3jcjm 13 12 of of IN cord-265139-x7g3jcjm 13 13 these these DT cord-265139-x7g3jcjm 13 14 RNA RNA NNP cord-265139-x7g3jcjm 13 15 transcripts transcript NNS cord-265139-x7g3jcjm 13 16 in in IN cord-265139-x7g3jcjm 13 17 the the DT cord-265139-x7g3jcjm 13 18 occurrence occurrence NN cord-265139-x7g3jcjm 13 19 and and CC cord-265139-x7g3jcjm 13 20 development development NN cord-265139-x7g3jcjm 13 21 of of IN cord-265139-x7g3jcjm 13 22 obesity obesity NN cord-265139-x7g3jcjm 13 23 . . . cord-265139-x7g3jcjm 14 1 Emerging emerge VBG cord-265139-x7g3jcjm 14 2 data datum NNS cord-265139-x7g3jcjm 14 3 from from IN cord-265139-x7g3jcjm 14 4 in in IN cord-265139-x7g3jcjm 14 5 vitro vitro FW cord-265139-x7g3jcjm 14 6 and and CC cord-265139-x7g3jcjm 14 7 in in IN cord-265139-x7g3jcjm 14 8 vivo vivo NNP cord-265139-x7g3jcjm 14 9 studies study NNS cord-265139-x7g3jcjm 14 10 suggest suggest VBP cord-265139-x7g3jcjm 14 11 that that IN cord-265139-x7g3jcjm 14 12 circRNAs circrna NNS cord-265139-x7g3jcjm 14 13 are be VBP cord-265139-x7g3jcjm 14 14 novel novel JJ cord-265139-x7g3jcjm 14 15 players player NNS cord-265139-x7g3jcjm 14 16 in in IN cord-265139-x7g3jcjm 14 17 adipogenesis adipogenesis NNP cord-265139-x7g3jcjm 14 18 , , , cord-265139-x7g3jcjm 14 19 white white JJ cord-265139-x7g3jcjm 14 20 adipose adipose JJ cord-265139-x7g3jcjm 14 21 browning browning NN cord-265139-x7g3jcjm 14 22 , , , cord-265139-x7g3jcjm 14 23 obesity obesity NN cord-265139-x7g3jcjm 14 24 , , , cord-265139-x7g3jcjm 14 25 obesity obesity NN cord-265139-x7g3jcjm 14 26 - - HYPH cord-265139-x7g3jcjm 14 27 induced induce VBN cord-265139-x7g3jcjm 14 28 inflammation inflammation NN cord-265139-x7g3jcjm 14 29 , , , cord-265139-x7g3jcjm 14 30 and and CC cord-265139-x7g3jcjm 14 31 insulin insulin NN cord-265139-x7g3jcjm 14 32 resistance resistance NN cord-265139-x7g3jcjm 14 33 . . . cord-265139-x7g3jcjm 15 1 This this DT cord-265139-x7g3jcjm 15 2 study study NN cord-265139-x7g3jcjm 15 3 explores explore VBZ cord-265139-x7g3jcjm 15 4 the the DT cord-265139-x7g3jcjm 15 5 current current JJ cord-265139-x7g3jcjm 15 6 state state NN cord-265139-x7g3jcjm 15 7 of of IN cord-265139-x7g3jcjm 15 8 knowledge knowledge NN cord-265139-x7g3jcjm 15 9 on on IN cord-265139-x7g3jcjm 15 10 circRNAs circrna NNS cord-265139-x7g3jcjm 15 11 regulating regulate VBG cord-265139-x7g3jcjm 15 12 molecular molecular JJ cord-265139-x7g3jcjm 15 13 processes process NNS cord-265139-x7g3jcjm 15 14 associated associate VBN cord-265139-x7g3jcjm 15 15 with with IN cord-265139-x7g3jcjm 15 16 adipogenesis adipogenesis NN cord-265139-x7g3jcjm 15 17 and and CC cord-265139-x7g3jcjm 15 18 obesity obesity NN cord-265139-x7g3jcjm 15 19 , , , cord-265139-x7g3jcjm 15 20 highlights highlight VBZ cord-265139-x7g3jcjm 15 21 some some DT cord-265139-x7g3jcjm 15 22 of of IN cord-265139-x7g3jcjm 15 23 the the DT cord-265139-x7g3jcjm 15 24 challenges challenge NNS cord-265139-x7g3jcjm 15 25 encountered encounter VBN cord-265139-x7g3jcjm 15 26 while while IN cord-265139-x7g3jcjm 15 27 studying study VBG cord-265139-x7g3jcjm 15 28 circRNAs circrna NNS cord-265139-x7g3jcjm 15 29 and and CC cord-265139-x7g3jcjm 15 30 suggests suggest VBZ cord-265139-x7g3jcjm 15 31 some some DT cord-265139-x7g3jcjm 15 32 perspectives perspective NNS cord-265139-x7g3jcjm 15 33 for for IN cord-265139-x7g3jcjm 15 34 future future JJ cord-265139-x7g3jcjm 15 35 research research NN cord-265139-x7g3jcjm 15 36 directions direction NNS cord-265139-x7g3jcjm 15 37 in in IN cord-265139-x7g3jcjm 15 38 this this DT cord-265139-x7g3jcjm 15 39 exciting exciting JJ cord-265139-x7g3jcjm 15 40 field field NN cord-265139-x7g3jcjm 15 41 of of IN cord-265139-x7g3jcjm 15 42 study study NN cord-265139-x7g3jcjm 15 43 . . . cord-265139-x7g3jcjm 16 1 Whole whole JJ cord-265139-x7g3jcjm 16 2 - - HYPH cord-265139-x7g3jcjm 16 3 genome genome NN cord-265139-x7g3jcjm 16 4 sequencing sequencing NN cord-265139-x7g3jcjm 16 5 studies study NNS cord-265139-x7g3jcjm 16 6 reveal reveal VBP cord-265139-x7g3jcjm 16 7 that that IN cord-265139-x7g3jcjm 16 8 our -PRON- PRP$ cord-265139-x7g3jcjm 16 9 genome genome NN cord-265139-x7g3jcjm 16 10 comprises comprise VBZ cord-265139-x7g3jcjm 16 11 approximately approximately RB cord-265139-x7g3jcjm 16 12 3 3 CD cord-265139-x7g3jcjm 16 13 to to IN cord-265139-x7g3jcjm 16 14 3.2 3.2 CD cord-265139-x7g3jcjm 16 15 billion billion CD cord-265139-x7g3jcjm 16 16 base base NN cord-265139-x7g3jcjm 16 17 pairs pair NNS cord-265139-x7g3jcjm 16 18 of of IN cord-265139-x7g3jcjm 16 19 DNA dna NN cord-265139-x7g3jcjm 16 20 , , , cord-265139-x7g3jcjm 16 21 but but CC cord-265139-x7g3jcjm 16 22 merely merely RB cord-265139-x7g3jcjm 16 23 1 1 CD cord-265139-x7g3jcjm 16 24 - - SYM cord-265139-x7g3jcjm 16 25 2 2 CD cord-265139-x7g3jcjm 16 26 % % NN cord-265139-x7g3jcjm 16 27 of of IN cord-265139-x7g3jcjm 16 28 those those DT cord-265139-x7g3jcjm 16 29 pairs pair NNS cord-265139-x7g3jcjm 16 30 correspond correspond VBP cord-265139-x7g3jcjm 16 31 to to IN cord-265139-x7g3jcjm 16 32 the the DT cord-265139-x7g3jcjm 16 33 annotated annotated JJ cord-265139-x7g3jcjm 16 34 exons exon NNS cord-265139-x7g3jcjm 16 35 of of IN cord-265139-x7g3jcjm 16 36 protein protein NN cord-265139-x7g3jcjm 16 37 - - HYPH cord-265139-x7g3jcjm 16 38 coding code VBG cord-265139-x7g3jcjm 16 39 genes gene NNS cord-265139-x7g3jcjm 16 40 . . . cord-265139-x7g3jcjm 17 1 The the DT cord-265139-x7g3jcjm 17 2 remaining remain VBG cord-265139-x7g3jcjm 17 3 98 98 CD cord-265139-x7g3jcjm 17 4 - - SYM cord-265139-x7g3jcjm 17 5 99 99 CD cord-265139-x7g3jcjm 17 6 % % NN cord-265139-x7g3jcjm 17 7 have have VBP cord-265139-x7g3jcjm 17 8 been be VBN cord-265139-x7g3jcjm 17 9 referred refer VBN cord-265139-x7g3jcjm 17 10 to to IN cord-265139-x7g3jcjm 17 11 as as IN cord-265139-x7g3jcjm 17 12 " " `` cord-265139-x7g3jcjm 17 13 junk junk NN cord-265139-x7g3jcjm 17 14 DNA dna NN cord-265139-x7g3jcjm 17 15 " " '' cord-265139-x7g3jcjm 17 16 or or CC cord-265139-x7g3jcjm 17 17 " " `` cord-265139-x7g3jcjm 17 18 dark dark JJ cord-265139-x7g3jcjm 17 19 matter matter NN cord-265139-x7g3jcjm 17 20 " " '' cord-265139-x7g3jcjm 17 21 with with IN cord-265139-x7g3jcjm 17 22 no no DT cord-265139-x7g3jcjm 17 23 obvious obvious JJ cord-265139-x7g3jcjm 17 24 function function NN cord-265139-x7g3jcjm 17 25 in in IN cord-265139-x7g3jcjm 17 26 the the DT cord-265139-x7g3jcjm 17 27 cell cell NN cord-265139-x7g3jcjm 17 28 [ [ -LRB- cord-265139-x7g3jcjm 17 29 1 1 CD cord-265139-x7g3jcjm 17 30 ] ] -RRB- cord-265139-x7g3jcjm 17 31 . . . cord-265139-x7g3jcjm 18 1 Currently currently RB cord-265139-x7g3jcjm 18 2 , , , cord-265139-x7g3jcjm 18 3 major major JJ cord-265139-x7g3jcjm 18 4 scientific scientific JJ cord-265139-x7g3jcjm 18 5 advances advance NNS cord-265139-x7g3jcjm 18 6 in in IN cord-265139-x7g3jcjm 18 7 the the DT cord-265139-x7g3jcjm 18 8 field field NN cord-265139-x7g3jcjm 18 9 that that WDT cord-265139-x7g3jcjm 18 10 have have VBP cord-265139-x7g3jcjm 18 11 occurred occur VBN cord-265139-x7g3jcjm 18 12 upon upon IN cord-265139-x7g3jcjm 18 13 implementation implementation NN cord-265139-x7g3jcjm 18 14 of of IN cord-265139-x7g3jcjm 18 15 novel novel JJ cord-265139-x7g3jcjm 18 16 and and CC cord-265139-x7g3jcjm 18 17 sensitive sensitive JJ cord-265139-x7g3jcjm 18 18 molecular molecular JJ cord-265139-x7g3jcjm 18 19 approaches approach NNS cord-265139-x7g3jcjm 18 20 to to IN cord-265139-x7g3jcjm 18 21 genome genome NN cord-265139-x7g3jcjm 18 22 - - HYPH cord-265139-x7g3jcjm 18 23 wide wide JJ cord-265139-x7g3jcjm 18 24 transcriptome transcriptome NN cord-265139-x7g3jcjm 18 25 analysis analysis NN cord-265139-x7g3jcjm 18 26 [ [ -LRB- cord-265139-x7g3jcjm 18 27 2 2 CD cord-265139-x7g3jcjm 18 28 ] ] -RRB- cord-265139-x7g3jcjm 18 29 , , , cord-265139-x7g3jcjm 18 30 have have VBP cord-265139-x7g3jcjm 18 31 totally totally RB cord-265139-x7g3jcjm 18 32 changed change VBN cord-265139-x7g3jcjm 18 33 the the DT cord-265139-x7g3jcjm 18 34 way way NN cord-265139-x7g3jcjm 18 35 we -PRON- PRP cord-265139-x7g3jcjm 18 36 look look VBP cord-265139-x7g3jcjm 18 37 at at IN cord-265139-x7g3jcjm 18 38 the the DT cord-265139-x7g3jcjm 18 39 vast vast JJ cord-265139-x7g3jcjm 18 40 " " `` cord-265139-x7g3jcjm 18 41 noncoding noncoding JJ cord-265139-x7g3jcjm 18 42 " " '' cord-265139-x7g3jcjm 18 43 regions region NNS cord-265139-x7g3jcjm 18 44 of of IN cord-265139-x7g3jcjm 18 45 the the DT cord-265139-x7g3jcjm 18 46 human human JJ cord-265139-x7g3jcjm 18 47 genome genome NN cord-265139-x7g3jcjm 18 48 . . . cord-265139-x7g3jcjm 19 1 What what WP cord-265139-x7g3jcjm 19 2 was be VBD cord-265139-x7g3jcjm 19 3 once once RB cord-265139-x7g3jcjm 19 4 considered consider VBN cord-265139-x7g3jcjm 19 5 " " `` cord-265139-x7g3jcjm 19 6 junk junk NN cord-265139-x7g3jcjm 19 7 DNA dna NN cord-265139-x7g3jcjm 19 8 " " '' cord-265139-x7g3jcjm 19 9 because because IN cord-265139-x7g3jcjm 19 10 of of IN cord-265139-x7g3jcjm 19 11 its -PRON- PRP$ cord-265139-x7g3jcjm 19 12 lack lack NN cord-265139-x7g3jcjm 19 13 of of IN cord-265139-x7g3jcjm 19 14 function function NN cord-265139-x7g3jcjm 19 15 is be VBZ cord-265139-x7g3jcjm 19 16 now now RB cord-265139-x7g3jcjm 19 17 viewed view VBN cord-265139-x7g3jcjm 19 18 as as IN cord-265139-x7g3jcjm 19 19 a a DT cord-265139-x7g3jcjm 19 20 treasure treasure NN cord-265139-x7g3jcjm 19 21 . . . cord-265139-x7g3jcjm 20 1 It -PRON- PRP cord-265139-x7g3jcjm 20 2 is be VBZ cord-265139-x7g3jcjm 20 3 becoming become VBG cord-265139-x7g3jcjm 20 4 known know VBN cord-265139-x7g3jcjm 20 5 from from IN cord-265139-x7g3jcjm 20 6 multiple multiple JJ cord-265139-x7g3jcjm 20 7 studies study NNS cord-265139-x7g3jcjm 20 8 that that IN cord-265139-x7g3jcjm 20 9 junk junk NN cord-265139-x7g3jcjm 20 10 DNA dna NN cord-265139-x7g3jcjm 20 11 can can MD cord-265139-x7g3jcjm 20 12 be be VB cord-265139-x7g3jcjm 20 13 almost almost RB cord-265139-x7g3jcjm 20 14 entirely entirely RB cord-265139-x7g3jcjm 20 15 transcribed transcribe VBN cord-265139-x7g3jcjm 20 16 , , , cord-265139-x7g3jcjm 20 17 generating generate VBG cord-265139-x7g3jcjm 20 18 a a DT cord-265139-x7g3jcjm 20 19 huge huge JJ cord-265139-x7g3jcjm 20 20 number number NN cord-265139-x7g3jcjm 20 21 of of IN cord-265139-x7g3jcjm 20 22 functional functional JJ cord-265139-x7g3jcjm 20 23 transcripts transcript NNS cord-265139-x7g3jcjm 20 24 commonly commonly RB cord-265139-x7g3jcjm 20 25 referred refer VBD cord-265139-x7g3jcjm 20 26 to to IN cord-265139-x7g3jcjm 20 27 as as IN cord-265139-x7g3jcjm 20 28 noncoding noncoding JJ cord-265139-x7g3jcjm 20 29 RNAs rna NNS cord-265139-x7g3jcjm 20 30 ( ( -LRB- cord-265139-x7g3jcjm 20 31 ncRNAs ncRNAs NNP cord-265139-x7g3jcjm 20 32 ) ) -RRB- cord-265139-x7g3jcjm 20 33 although although IN cord-265139-x7g3jcjm 20 34 many many JJ cord-265139-x7g3jcjm 20 35 of of IN cord-265139-x7g3jcjm 20 36 their -PRON- PRP$ cord-265139-x7g3jcjm 20 37 functions function NNS cord-265139-x7g3jcjm 20 38 remain remain VBP cord-265139-x7g3jcjm 20 39 enigmatic enigmatic JJ cord-265139-x7g3jcjm 20 40 [ [ -LRB- cord-265139-x7g3jcjm 20 41 3 3 CD cord-265139-x7g3jcjm 20 42 , , , cord-265139-x7g3jcjm 20 43 4 4 CD cord-265139-x7g3jcjm 20 44 ] ] -RRB- cord-265139-x7g3jcjm 20 45 . . . cord-265139-x7g3jcjm 21 1 According accord VBG cord-265139-x7g3jcjm 21 2 to to IN cord-265139-x7g3jcjm 21 3 the the DT cord-265139-x7g3jcjm 21 4 biological biological JJ cord-265139-x7g3jcjm 21 5 functions function NNS cord-265139-x7g3jcjm 21 6 of of IN cord-265139-x7g3jcjm 21 7 ncRNAs ncRNAs NNP cord-265139-x7g3jcjm 21 8 , , , cord-265139-x7g3jcjm 21 9 they -PRON- PRP cord-265139-x7g3jcjm 21 10 can can MD cord-265139-x7g3jcjm 21 11 be be VB cord-265139-x7g3jcjm 21 12 classified classify VBN cord-265139-x7g3jcjm 21 13 into into IN cord-265139-x7g3jcjm 21 14 infrastructural infrastructural JJ cord-265139-x7g3jcjm 21 15 and and CC cord-265139-x7g3jcjm 21 16 regulatory regulatory JJ cord-265139-x7g3jcjm 21 17 types type NNS cord-265139-x7g3jcjm 21 18 . . . cord-265139-x7g3jcjm 22 1 Infrastructural infrastructural JJ cord-265139-x7g3jcjm 22 2 ncRNAs ncrna NNS cord-265139-x7g3jcjm 22 3 include include VBP cord-265139-x7g3jcjm 22 4 ribosomal ribosomal JJ cord-265139-x7g3jcjm 22 5 RNAs rna NNS cord-265139-x7g3jcjm 22 6 ( ( -LRB- cord-265139-x7g3jcjm 22 7 rRNAs rRNAs NNP cord-265139-x7g3jcjm 22 8 ) ) -RRB- cord-265139-x7g3jcjm 22 9 , , , cord-265139-x7g3jcjm 22 10 transfer transfer NN cord-265139-x7g3jcjm 22 11 RNAs rna NNS cord-265139-x7g3jcjm 22 12 ( ( -LRB- cord-265139-x7g3jcjm 22 13 tRNAs tRNAs NNP cord-265139-x7g3jcjm 22 14 ) ) -RRB- cord-265139-x7g3jcjm 22 15 , , , cord-265139-x7g3jcjm 22 16 and and CC cord-265139-x7g3jcjm 22 17 small small JJ cord-265139-x7g3jcjm 22 18 nuclear nuclear JJ cord-265139-x7g3jcjm 22 19 RNAs rna NNS cord-265139-x7g3jcjm 22 20 ( ( -LRB- cord-265139-x7g3jcjm 22 21 snRNAs snRNAs NNP cord-265139-x7g3jcjm 22 22 ) ) -RRB- cord-265139-x7g3jcjm 22 23 and and CC cord-265139-x7g3jcjm 22 24 are be VBP cord-265139-x7g3jcjm 22 25 typically typically RB cord-265139-x7g3jcjm 22 26 expressed express VBN cord-265139-x7g3jcjm 22 27 constitutively constitutively RB cord-265139-x7g3jcjm 22 28 , , , cord-265139-x7g3jcjm 22 29 whereas whereas IN cord-265139-x7g3jcjm 22 30 regulatory regulatory JJ cord-265139-x7g3jcjm 22 31 ncRNAs ncrna NNS cord-265139-x7g3jcjm 22 32 consist consist VBP cord-265139-x7g3jcjm 22 33 mainly mainly RB cord-265139-x7g3jcjm 22 34 of of IN cord-265139-x7g3jcjm 22 35 microRNAs microRNAs NNPS cord-265139-x7g3jcjm 22 36 ( ( -LRB- cord-265139-x7g3jcjm 22 37 miRNAs miRNAs NNP cord-265139-x7g3jcjm 22 38 ) ) -RRB- cord-265139-x7g3jcjm 22 39 , , . cord-265139-x7g3jcjm 23 1 long long JJ cord-265139-x7g3jcjm 23 2 noncoding noncoding JJ cord-265139-x7g3jcjm 23 3 RNAs rna NNS cord-265139-x7g3jcjm 23 4 ( ( -LRB- cord-265139-x7g3jcjm 23 5 lncRNAs lncRNAs NNP cord-265139-x7g3jcjm 23 6 ) ) -RRB- cord-265139-x7g3jcjm 23 7 , , , cord-265139-x7g3jcjm 23 8 circular circular JJ cord-265139-x7g3jcjm 23 9 RNAs rna NNS cord-265139-x7g3jcjm 23 10 ( ( -LRB- cord-265139-x7g3jcjm 23 11 circRNAs circRNAs NNP cord-265139-x7g3jcjm 23 12 ) ) -RRB- cord-265139-x7g3jcjm 23 13 , , , cord-265139-x7g3jcjm 23 14 and and CC cord-265139-x7g3jcjm 23 15 piwi piwi NN cord-265139-x7g3jcjm 23 16 - - HYPH cord-265139-x7g3jcjm 23 17 interacting interact VBG cord-265139-x7g3jcjm 23 18 RNAs rna NNS cord-265139-x7g3jcjm 23 19 ( ( -LRB- cord-265139-x7g3jcjm 23 20 piRNAs piRNAs NNP cord-265139-x7g3jcjm 23 21 ) ) -RRB- cord-265139-x7g3jcjm 23 22 . . . cord-265139-x7g3jcjm 24 1 Inconsistent inconsistent JJ cord-265139-x7g3jcjm 24 2 with with IN cord-265139-x7g3jcjm 24 3 the the DT cord-265139-x7g3jcjm 24 4 " " `` cord-265139-x7g3jcjm 24 5 central central JJ cord-265139-x7g3jcjm 24 6 dogma dogma NN cord-265139-x7g3jcjm 24 7 of of IN cord-265139-x7g3jcjm 24 8 biology biology NN cord-265139-x7g3jcjm 24 9 " " '' cord-265139-x7g3jcjm 24 10 that that WDT cord-265139-x7g3jcjm 24 11 describes describe VBZ cord-265139-x7g3jcjm 24 12 the the DT cord-265139-x7g3jcjm 24 13 flow flow NN cord-265139-x7g3jcjm 24 14 of of IN cord-265139-x7g3jcjm 24 15 genetic genetic JJ cord-265139-x7g3jcjm 24 16 information information NN cord-265139-x7g3jcjm 24 17 from from IN cord-265139-x7g3jcjm 24 18 gene gene NN cord-265139-x7g3jcjm 24 19 to to IN cord-265139-x7g3jcjm 24 20 mRNA mrna NN cord-265139-x7g3jcjm 24 21 and and CC cord-265139-x7g3jcjm 24 22 finally finally RB cord-265139-x7g3jcjm 24 23 to to TO cord-265139-x7g3jcjm 24 24 protein protein NN cord-265139-x7g3jcjm 24 25 , , , cord-265139-x7g3jcjm 24 26 ncRNAs ncrna NNS cord-265139-x7g3jcjm 24 27 are be VBP cord-265139-x7g3jcjm 24 28 generally generally RB cord-265139-x7g3jcjm 24 29 not not RB cord-265139-x7g3jcjm 24 30 further further RB cord-265139-x7g3jcjm 24 31 translated translate VBN cord-265139-x7g3jcjm 24 32 into into IN cord-265139-x7g3jcjm 24 33 proteins protein NNS cord-265139-x7g3jcjm 24 34 [ [ -LRB- cord-265139-x7g3jcjm 24 35 5 5 CD cord-265139-x7g3jcjm 24 36 ] ] -RRB- cord-265139-x7g3jcjm 24 37 . . . cord-265139-x7g3jcjm 25 1 Although although IN cord-265139-x7g3jcjm 25 2 they -PRON- PRP cord-265139-x7g3jcjm 25 3 do do VBP cord-265139-x7g3jcjm 25 4 not not RB cord-265139-x7g3jcjm 25 5 encode encode VB cord-265139-x7g3jcjm 25 6 proteins protein NNS cord-265139-x7g3jcjm 25 7 , , , cord-265139-x7g3jcjm 25 8 these these DT cord-265139-x7g3jcjm 25 9 RNA RNA NNP cord-265139-x7g3jcjm 25 10 molecules molecule NNS cord-265139-x7g3jcjm 25 11 can can MD cord-265139-x7g3jcjm 25 12 still still RB cord-265139-x7g3jcjm 25 13 be be VB cord-265139-x7g3jcjm 25 14 endowed endow VBN cord-265139-x7g3jcjm 25 15 with with IN cord-265139-x7g3jcjm 25 16 critical critical JJ cord-265139-x7g3jcjm 25 17 regulatory regulatory JJ cord-265139-x7g3jcjm 25 18 function function NN cord-265139-x7g3jcjm 25 19 and and CC cord-265139-x7g3jcjm 25 20 may may MD cord-265139-x7g3jcjm 25 21 help help VB cord-265139-x7g3jcjm 25 22 orchestrate orchestrate VB cord-265139-x7g3jcjm 25 23 a a DT cord-265139-x7g3jcjm 25 24 hidden hidden JJ cord-265139-x7g3jcjm 25 25 layer layer NN cord-265139-x7g3jcjm 25 26 of of IN cord-265139-x7g3jcjm 25 27 gene gene NN cord-265139-x7g3jcjm 25 28 regulation regulation NN cord-265139-x7g3jcjm 25 29 networks network NNS cord-265139-x7g3jcjm 25 30 [ [ -LRB- cord-265139-x7g3jcjm 25 31 6 6 CD cord-265139-x7g3jcjm 25 32 ] ] -RRB- cord-265139-x7g3jcjm 25 33 . . . cord-265139-x7g3jcjm 26 1 As as IN cord-265139-x7g3jcjm 26 2 a a DT cord-265139-x7g3jcjm 26 3 matter matter NN cord-265139-x7g3jcjm 26 4 of of IN cord-265139-x7g3jcjm 26 5 fact fact NN cord-265139-x7g3jcjm 26 6 , , , cord-265139-x7g3jcjm 26 7 circumstantial circumstantial JJ cord-265139-x7g3jcjm 26 8 evidence evidence NN cord-265139-x7g3jcjm 26 9 revealed reveal VBD cord-265139-x7g3jcjm 26 10 that that IN cord-265139-x7g3jcjm 26 11 ncRNAs ncRNAs NNP cord-265139-x7g3jcjm 26 12 can can MD cord-265139-x7g3jcjm 26 13 act act VB cord-265139-x7g3jcjm 26 14 as as IN cord-265139-x7g3jcjm 26 15 critical critical JJ cord-265139-x7g3jcjm 26 16 switches switch NNS cord-265139-x7g3jcjm 26 17 that that WDT cord-265139-x7g3jcjm 26 18 fine fine JJ cord-265139-x7g3jcjm 26 19 - - HYPH cord-265139-x7g3jcjm 26 20 tune tune NN cord-265139-x7g3jcjm 26 21 target target NN cord-265139-x7g3jcjm 26 22 gene gene NN cord-265139-x7g3jcjm 26 23 expression expression NN cord-265139-x7g3jcjm 26 24 [ [ -LRB- cord-265139-x7g3jcjm 26 25 7 7 CD cord-265139-x7g3jcjm 26 26 , , , cord-265139-x7g3jcjm 26 27 8 8 CD cord-265139-x7g3jcjm 26 28 ] ] -RRB- cord-265139-x7g3jcjm 26 29 . . . cord-265139-x7g3jcjm 27 1 From from IN cord-265139-x7g3jcjm 27 2 a a DT cord-265139-x7g3jcjm 27 3 clinical clinical JJ cord-265139-x7g3jcjm 27 4 perspective perspective NN cord-265139-x7g3jcjm 27 5 , , , cord-265139-x7g3jcjm 27 6 several several JJ cord-265139-x7g3jcjm 27 7 transcriptomic transcriptomic JJ cord-265139-x7g3jcjm 27 8 studies study NNS cord-265139-x7g3jcjm 27 9 have have VBP cord-265139-x7g3jcjm 27 10 unveiled unveil VBN cord-265139-x7g3jcjm 27 11 that that IN cord-265139-x7g3jcjm 27 12 a a DT cord-265139-x7g3jcjm 27 13 large large JJ cord-265139-x7g3jcjm 27 14 number number NN cord-265139-x7g3jcjm 27 15 of of IN cord-265139-x7g3jcjm 27 16 ncRNAs ncrna NNS cord-265139-x7g3jcjm 27 17 can can MD cord-265139-x7g3jcjm 27 18 be be VB cord-265139-x7g3jcjm 27 19 altered alter VBN cord-265139-x7g3jcjm 27 20 in in IN cord-265139-x7g3jcjm 27 21 major major JJ cord-265139-x7g3jcjm 27 22 diseases disease NNS cord-265139-x7g3jcjm 27 23 [ [ -LRB- cord-265139-x7g3jcjm 27 24 9 9 CD cord-265139-x7g3jcjm 27 25 ] ] -RRB- cord-265139-x7g3jcjm 27 26 clearly clearly RB cord-265139-x7g3jcjm 27 27 hinting hint VBG cord-265139-x7g3jcjm 27 28 towards towards IN cord-265139-x7g3jcjm 27 29 the the DT cord-265139-x7g3jcjm 27 30 potential potential JJ cord-265139-x7g3jcjm 27 31 therapeutic therapeutic JJ cord-265139-x7g3jcjm 27 32 application application NN cord-265139-x7g3jcjm 27 33 of of IN cord-265139-x7g3jcjm 27 34 these these DT cord-265139-x7g3jcjm 27 35 RNA RNA NNP cord-265139-x7g3jcjm 27 36 molecules molecule NNS cord-265139-x7g3jcjm 27 37 in in IN cord-265139-x7g3jcjm 27 38 disease disease NN cord-265139-x7g3jcjm 27 39 therapy therapy NN cord-265139-x7g3jcjm 27 40 . . . cord-265139-x7g3jcjm 28 1 As as IN cord-265139-x7g3jcjm 28 2 stated state VBN cord-265139-x7g3jcjm 28 3 before before RB cord-265139-x7g3jcjm 28 4 , , , cord-265139-x7g3jcjm 28 5 there there EX cord-265139-x7g3jcjm 28 6 are be VBP cord-265139-x7g3jcjm 28 7 different different JJ cord-265139-x7g3jcjm 28 8 types type NNS cord-265139-x7g3jcjm 28 9 of of IN cord-265139-x7g3jcjm 28 10 ncRNA ncRNA NNP cord-265139-x7g3jcjm 28 11 transcriptomes transcriptomes NNP cord-265139-x7g3jcjm 28 12 with with IN cord-265139-x7g3jcjm 28 13 varied varied JJ cord-265139-x7g3jcjm 28 14 functions function NNS cord-265139-x7g3jcjm 28 15 ; ; : cord-265139-x7g3jcjm 28 16 among among IN cord-265139-x7g3jcjm 28 17 the the DT cord-265139-x7g3jcjm 28 18 most most RBS cord-265139-x7g3jcjm 28 19 relevant relevant JJ cord-265139-x7g3jcjm 28 20 are be VBP cord-265139-x7g3jcjm 28 21 small small JJ cord-265139-x7g3jcjm 28 22 ncRNAs ncrna NNS cord-265139-x7g3jcjm 28 23 such such JJ cord-265139-x7g3jcjm 28 24 as as IN cord-265139-x7g3jcjm 28 25 miRNAs miRNAs NNP cord-265139-x7g3jcjm 28 26 ( ( -LRB- cord-265139-x7g3jcjm 28 27 18 18 CD cord-265139-x7g3jcjm 28 28 - - SYM cord-265139-x7g3jcjm 28 29 24 24 CD cord-265139-x7g3jcjm 28 30 nucleotides nucleotide NNS cord-265139-x7g3jcjm 28 31 ( ( -LRB- cord-265139-x7g3jcjm 28 32 nt nt RB cord-265139-x7g3jcjm 28 33 . . . cord-265139-x7g3jcjm 28 34 ) ) -RRB- cord-265139-x7g3jcjm 28 35 ) ) -RRB- cord-265139-x7g3jcjm 28 36 , , . cord-265139-x7g3jcjm 29 1 lncRNAs lncrnas RB cord-265139-x7g3jcjm 30 1 ( ( -LRB- cord-265139-x7g3jcjm 30 2 > > XX cord-265139-x7g3jcjm 31 1 200 200 CD cord-265139-x7g3jcjm 31 2 nt nt RB cord-265139-x7g3jcjm 31 3 . . . cord-265139-x7g3jcjm 31 4 ) ) -RRB- cord-265139-x7g3jcjm 31 5 , , . cord-265139-x7g3jcjm 32 1 and and CC cord-265139-x7g3jcjm 32 2 circRNAs circRNAs NNP cord-265139-x7g3jcjm 32 3 ( ( -LRB- cord-265139-x7g3jcjm 32 4 median median JJ cord-265139-x7g3jcjm 32 5 length length NN cord-265139-x7g3jcjm 32 6 is~530 is~530 NN cord-265139-x7g3jcjm 32 7 nt nt RB cord-265139-x7g3jcjm 32 8 . . . cord-265139-x7g3jcjm 32 9 ) ) -RRB- cord-265139-x7g3jcjm 32 10 . . . cord-265139-x7g3jcjm 33 1 In in IN cord-265139-x7g3jcjm 33 2 recent recent JJ cord-265139-x7g3jcjm 33 3 years year NNS cord-265139-x7g3jcjm 33 4 , , , cord-265139-x7g3jcjm 33 5 considerable considerable JJ cord-265139-x7g3jcjm 33 6 attention attention NN cord-265139-x7g3jcjm 33 7 has have VBZ cord-265139-x7g3jcjm 33 8 focused focus VBN cord-265139-x7g3jcjm 33 9 on on IN cord-265139-x7g3jcjm 33 10 circRNAs circrna NNS cord-265139-x7g3jcjm 33 11 , , , cord-265139-x7g3jcjm 33 12 which which WDT cord-265139-x7g3jcjm 33 13 are be VBP cord-265139-x7g3jcjm 33 14 distinguished distinguish VBN cord-265139-x7g3jcjm 33 15 from from IN cord-265139-x7g3jcjm 33 16 their -PRON- PRP$ cord-265139-x7g3jcjm 33 17 linear linear JJ cord-265139-x7g3jcjm 33 18 counterparts counterpart NNS cord-265139-x7g3jcjm 33 19 by by IN cord-265139-x7g3jcjm 33 20 the the DT cord-265139-x7g3jcjm 33 21 unique unique JJ cord-265139-x7g3jcjm 33 22 structure structure NN cord-265139-x7g3jcjm 33 23 of of IN cord-265139-x7g3jcjm 33 24 covalently covalently RB cord-265139-x7g3jcjm 33 25 closed close VBN cord-265139-x7g3jcjm 33 26 continuous continuous JJ cord-265139-x7g3jcjm 33 27 loop loop NN cord-265139-x7g3jcjm 33 28 lacking lack VBG cord-265139-x7g3jcjm 33 29 5 5 CD cord-265139-x7g3jcjm 33 30 cap cap NN cord-265139-x7g3jcjm 33 31 and and CC cord-265139-x7g3jcjm 33 32 3 3 CD cord-265139-x7g3jcjm 33 33 poly poly NN cord-265139-x7g3jcjm 33 34 - - HYPH cord-265139-x7g3jcjm 33 35 adenylated adenylate VBN cord-265139-x7g3jcjm 33 36 tails tail NNS cord-265139-x7g3jcjm 33 37 [ [ -LRB- cord-265139-x7g3jcjm 33 38 10 10 CD cord-265139-x7g3jcjm 33 39 ] ] -RRB- cord-265139-x7g3jcjm 33 40 . . . cord-265139-x7g3jcjm 34 1 This this DT cord-265139-x7g3jcjm 34 2 feature feature NN cord-265139-x7g3jcjm 34 3 makes make VBZ cord-265139-x7g3jcjm 34 4 circRNAs circrna NNS cord-265139-x7g3jcjm 34 5 remarkably remarkably RB cord-265139-x7g3jcjm 34 6 stable stable JJ cord-265139-x7g3jcjm 34 7 and and CC cord-265139-x7g3jcjm 34 8 resistant resistant JJ cord-265139-x7g3jcjm 34 9 to to IN cord-265139-x7g3jcjm 34 10 degradation degradation NN cord-265139-x7g3jcjm 34 11 by by IN cord-265139-x7g3jcjm 34 12 exonuclease exonuclease NN cord-265139-x7g3jcjm 34 13 and and CC cord-265139-x7g3jcjm 34 14 RNases RNases NNPS cord-265139-x7g3jcjm 34 15 , , , cord-265139-x7g3jcjm 34 16 therefore therefore RB cord-265139-x7g3jcjm 34 17 , , , cord-265139-x7g3jcjm 34 18 they -PRON- PRP cord-265139-x7g3jcjm 34 19 are be VBP cord-265139-x7g3jcjm 34 20 proposed propose VBN cord-265139-x7g3jcjm 34 21 as as IN cord-265139-x7g3jcjm 34 22 new new JJ cord-265139-x7g3jcjm 34 23 generation generation NN cord-265139-x7g3jcjm 34 24 of of IN cord-265139-x7g3jcjm 34 25 predictive predictive JJ cord-265139-x7g3jcjm 34 26 biomarkers biomarker NNS cord-265139-x7g3jcjm 34 27 and and CC cord-265139-x7g3jcjm 34 28 potential potential JJ cord-265139-x7g3jcjm 34 29 therapeutic therapeutic JJ cord-265139-x7g3jcjm 34 30 targets target NNS cord-265139-x7g3jcjm 34 31 for for IN cord-265139-x7g3jcjm 34 32 many many JJ cord-265139-x7g3jcjm 34 33 diseases disease NNS cord-265139-x7g3jcjm 34 34 . . . cord-265139-x7g3jcjm 35 1 Even even RB cord-265139-x7g3jcjm 35 2 though though IN cord-265139-x7g3jcjm 35 3 evidence evidence NN cord-265139-x7g3jcjm 35 4 of of IN cord-265139-x7g3jcjm 35 5 their -PRON- PRP$ cord-265139-x7g3jcjm 35 6 biological biological JJ cord-265139-x7g3jcjm 35 7 relevance relevance NN cord-265139-x7g3jcjm 35 8 and and CC cord-265139-x7g3jcjm 35 9 clinical clinical JJ cord-265139-x7g3jcjm 35 10 significance significance NN cord-265139-x7g3jcjm 35 11 in in IN cord-265139-x7g3jcjm 35 12 human human JJ cord-265139-x7g3jcjm 35 13 disease disease NN cord-265139-x7g3jcjm 35 14 pathogenesis pathogenesis NN cord-265139-x7g3jcjm 35 15 is be VBZ cord-265139-x7g3jcjm 35 16 continuously continuously RB cord-265139-x7g3jcjm 35 17 emerging emerge VBG cord-265139-x7g3jcjm 35 18 , , , cord-265139-x7g3jcjm 35 19 our -PRON- PRP$ cord-265139-x7g3jcjm 35 20 current current JJ cord-265139-x7g3jcjm 35 21 knowledge knowledge NN cord-265139-x7g3jcjm 35 22 of of IN cord-265139-x7g3jcjm 35 23 circRNAs circRNAs NNP cord-265139-x7g3jcjm 35 24 remains remain VBZ cord-265139-x7g3jcjm 35 25 preliminary preliminary JJ cord-265139-x7g3jcjm 35 26 in in IN cord-265139-x7g3jcjm 35 27 metabolic metabolic JJ cord-265139-x7g3jcjm 35 28 diseases disease NNS cord-265139-x7g3jcjm 35 29 and and CC cord-265139-x7g3jcjm 35 30 obesity obesity NN cord-265139-x7g3jcjm 35 31 in in IN cord-265139-x7g3jcjm 35 32 particular particular JJ cord-265139-x7g3jcjm 35 33 . . . cord-265139-x7g3jcjm 36 1 Additionally additionally RB cord-265139-x7g3jcjm 36 2 , , , cord-265139-x7g3jcjm 36 3 to to IN cord-265139-x7g3jcjm 36 4 the the DT cord-265139-x7g3jcjm 36 5 very very RB cord-265139-x7g3jcjm 36 6 best good JJS cord-265139-x7g3jcjm 36 7 of of IN cord-265139-x7g3jcjm 36 8 my -PRON- PRP$ cord-265139-x7g3jcjm 36 9 knowledge knowledge NN cord-265139-x7g3jcjm 36 10 , , , cord-265139-x7g3jcjm 36 11 there there EX cord-265139-x7g3jcjm 36 12 is be VBZ cord-265139-x7g3jcjm 36 13 hardly hardly RB cord-265139-x7g3jcjm 36 14 any any DT cord-265139-x7g3jcjm 36 15 comprehensive comprehensive JJ cord-265139-x7g3jcjm 36 16 coverage coverage NN cord-265139-x7g3jcjm 36 17 on on IN cord-265139-x7g3jcjm 36 18 the the DT cord-265139-x7g3jcjm 36 19 role role NN cord-265139-x7g3jcjm 36 20 of of IN cord-265139-x7g3jcjm 36 21 circRNAs circrna NNS cord-265139-x7g3jcjm 36 22 in in IN cord-265139-x7g3jcjm 36 23 the the DT cord-265139-x7g3jcjm 36 24 pathogenesis pathogenesis NN cord-265139-x7g3jcjm 36 25 of of IN cord-265139-x7g3jcjm 36 26 obesity obesity NN cord-265139-x7g3jcjm 36 27 . . . cord-265139-x7g3jcjm 37 1 Hence hence RB cord-265139-x7g3jcjm 37 2 , , , cord-265139-x7g3jcjm 37 3 the the DT cord-265139-x7g3jcjm 37 4 next next JJ cord-265139-x7g3jcjm 37 5 sections section NNS cord-265139-x7g3jcjm 37 6 will will MD cord-265139-x7g3jcjm 37 7 discuss discuss VB cord-265139-x7g3jcjm 37 8 relevant relevant JJ cord-265139-x7g3jcjm 37 9 literature literature NN cord-265139-x7g3jcjm 37 10 in in IN cord-265139-x7g3jcjm 37 11 the the DT cord-265139-x7g3jcjm 37 12 field field NN cord-265139-x7g3jcjm 37 13 and and CC cord-265139-x7g3jcjm 37 14 highlight highlight VB cord-265139-x7g3jcjm 37 15 some some DT cord-265139-x7g3jcjm 37 16 of of IN cord-265139-x7g3jcjm 37 17 the the DT cord-265139-x7g3jcjm 37 18 key key JJ cord-265139-x7g3jcjm 37 19 aspects aspect NNS cord-265139-x7g3jcjm 37 20 of of IN cord-265139-x7g3jcjm 37 21 circRNAs circrna NNS cord-265139-x7g3jcjm 37 22 and and CC cord-265139-x7g3jcjm 37 23 challenges challenge NNS cord-265139-x7g3jcjm 37 24 ahead ahead RB cord-265139-x7g3jcjm 37 25 . . . cord-265139-x7g3jcjm 38 1 Contrary contrary JJ cord-265139-x7g3jcjm 38 2 to to IN cord-265139-x7g3jcjm 38 3 conventional conventional JJ cord-265139-x7g3jcjm 38 4 splicing splicing NN cord-265139-x7g3jcjm 38 5 forming form VBG cord-265139-x7g3jcjm 38 6 a a DT cord-265139-x7g3jcjm 38 7 linear linear JJ cord-265139-x7g3jcjm 38 8 RNA RNA NNP cord-265139-x7g3jcjm 38 9 , , , cord-265139-x7g3jcjm 38 10 circRNAs circrna NNS cord-265139-x7g3jcjm 38 11 are be VBP cord-265139-x7g3jcjm 38 12 generally generally RB cord-265139-x7g3jcjm 38 13 derived derive VBN cord-265139-x7g3jcjm 38 14 from from IN cord-265139-x7g3jcjm 38 15 precursor precursor NN cord-265139-x7g3jcjm 39 1 mRNA mRNA NNP cord-265139-x7g3jcjm 39 2 back back RB cord-265139-x7g3jcjm 39 3 - - HYPH cord-265139-x7g3jcjm 39 4 splicing splicing NN cord-265139-x7g3jcjm 39 5 , , , cord-265139-x7g3jcjm 39 6 a a DT cord-265139-x7g3jcjm 39 7 molecular molecular JJ cord-265139-x7g3jcjm 39 8 event event NN cord-265139-x7g3jcjm 39 9 in in IN cord-265139-x7g3jcjm 39 10 which which WDT cord-265139-x7g3jcjm 39 11 a a DT cord-265139-x7g3jcjm 39 12 downstream downstream JJ cord-265139-x7g3jcjm 39 13 5 5 CD cord-265139-x7g3jcjm 39 14 splice splice NN cord-265139-x7g3jcjm 39 15 site site NN cord-265139-x7g3jcjm 39 16 is be VBZ cord-265139-x7g3jcjm 39 17 joined join VBN cord-265139-x7g3jcjm 39 18 to to IN cord-265139-x7g3jcjm 39 19 a a DT cord-265139-x7g3jcjm 39 20 downstream downstream JJ cord-265139-x7g3jcjm 39 21 3 3 CD cord-265139-x7g3jcjm 39 22 splice splice NN cord-265139-x7g3jcjm 39 23 site site NN cord-265139-x7g3jcjm 39 24 to to TO cord-265139-x7g3jcjm 39 25 form form VB cord-265139-x7g3jcjm 39 26 a a DT cord-265139-x7g3jcjm 39 27 covalently covalently RB cord-265139-x7g3jcjm 39 28 closed closed JJ cord-265139-x7g3jcjm 39 29 circular circular JJ cord-265139-x7g3jcjm 39 30 structure structure NN cord-265139-x7g3jcjm 39 31 [ [ -LRB- cord-265139-x7g3jcjm 39 32 11 11 CD cord-265139-x7g3jcjm 39 33 ] ] -RRB- cord-265139-x7g3jcjm 39 34 . . . cord-265139-x7g3jcjm 40 1 Even even RB cord-265139-x7g3jcjm 40 2 though though IN cord-265139-x7g3jcjm 40 3 the the DT cord-265139-x7g3jcjm 40 4 specific specific JJ cord-265139-x7g3jcjm 40 5 and and CC cord-265139-x7g3jcjm 40 6 detailed detailed JJ cord-265139-x7g3jcjm 40 7 mechanisms mechanism NNS cord-265139-x7g3jcjm 40 8 mediating mediate VBG cord-265139-x7g3jcjm 40 9 circRNAs circrnas JJ cord-265139-x7g3jcjm 40 10 biogenesis biogenesis NN cord-265139-x7g3jcjm 40 11 are be VBP cord-265139-x7g3jcjm 40 12 not not RB cord-265139-x7g3jcjm 40 13 fully fully RB cord-265139-x7g3jcjm 40 14 understood understand VBN cord-265139-x7g3jcjm 40 15 , , , cord-265139-x7g3jcjm 40 16 several several JJ cord-265139-x7g3jcjm 40 17 models model NNS cord-265139-x7g3jcjm 40 18 have have VBP cord-265139-x7g3jcjm 40 19 been be VBN cord-265139-x7g3jcjm 40 20 proposed propose VBN cord-265139-x7g3jcjm 40 21 , , , cord-265139-x7g3jcjm 40 22 including include VBG cord-265139-x7g3jcjm 40 23 direct direct JJ cord-265139-x7g3jcjm 40 24 back back NN cord-265139-x7g3jcjm 40 25 - - HYPH cord-265139-x7g3jcjm 40 26 splicing splicing NN cord-265139-x7g3jcjm 40 27 with with IN cord-265139-x7g3jcjm 40 28 Arthrobacter Arthrobacter NNP cord-265139-x7g3jcjm 40 29 luteus luteu NNS cord-265139-x7g3jcjm 40 30 ( ( -LRB- cord-265139-x7g3jcjm 40 31 ALU ALU NNP cord-265139-x7g3jcjm 40 32 ) ) -RRB- cord-265139-x7g3jcjm 40 33 elements element NNS cord-265139-x7g3jcjm 40 34 and and CC cord-265139-x7g3jcjm 40 35 inverted inverted JJ cord-265139-x7g3jcjm 40 36 repeats repeat VBZ cord-265139-x7g3jcjm 40 37 complementation complementation NN cord-265139-x7g3jcjm 40 38 , , , cord-265139-x7g3jcjm 40 39 lariat lariat NN cord-265139-x7g3jcjm 40 40 - - HYPH cord-265139-x7g3jcjm 40 41 driven drive VBN cord-265139-x7g3jcjm 40 42 circularization circularization NN cord-265139-x7g3jcjm 40 43 ( ( -LRB- cord-265139-x7g3jcjm 40 44 exon exon NN cord-265139-x7g3jcjm 40 45 skipping skip VBG cord-265139-x7g3jcjm 40 46 ) ) -RRB- cord-265139-x7g3jcjm 40 47 , , , cord-265139-x7g3jcjm 40 48 and and CC cord-265139-x7g3jcjm 40 49 RNA rna NN cord-265139-x7g3jcjm 40 50 - - HYPH cord-265139-x7g3jcjm 40 51 binding bind VBG cord-265139-x7g3jcjm 40 52 - - HYPH cord-265139-x7g3jcjm 40 53 protein protein NN cord-265139-x7g3jcjm 40 54 ( ( -LRB- cord-265139-x7g3jcjm 40 55 RBP RBP NNP cord-265139-x7g3jcjm 40 56 ) ) -RRB- cord-265139-x7g3jcjm 40 57 mediated mediate VBN cord-265139-x7g3jcjm 40 58 models model NNS cord-265139-x7g3jcjm 40 59 [ [ -LRB- cord-265139-x7g3jcjm 40 60 12 12 CD cord-265139-x7g3jcjm 40 61 ] ] -RRB- cord-265139-x7g3jcjm 40 62 . . . cord-265139-x7g3jcjm 41 1 Based base VBN cord-265139-x7g3jcjm 41 2 on on IN cord-265139-x7g3jcjm 41 3 their -PRON- PRP$ cord-265139-x7g3jcjm 41 4 sequences sequence NNS cord-265139-x7g3jcjm 41 5 , , , cord-265139-x7g3jcjm 41 6 circRNAs circRNAs NNP cord-265139-x7g3jcjm 41 7 can can MD cord-265139-x7g3jcjm 41 8 be be VB cord-265139-x7g3jcjm 41 9 generally generally RB cord-265139-x7g3jcjm 41 10 classified classify VBN cord-265139-x7g3jcjm 41 11 into into IN cord-265139-x7g3jcjm 41 12 three three CD cord-265139-x7g3jcjm 41 13 categories category NNS cord-265139-x7g3jcjm 41 14 : : : cord-265139-x7g3jcjm 41 15 i i NN cord-265139-x7g3jcjm 41 16 ) ) -RRB- cord-265139-x7g3jcjm 42 1 exonic exonic NNP cord-265139-x7g3jcjm 42 2 circRNAs circRNAs NNP cord-265139-x7g3jcjm 42 3 ( ( -LRB- cord-265139-x7g3jcjm 42 4 EcircRNAs EcircRNAs NNP cord-265139-x7g3jcjm 42 5 ) ) -RRB- cord-265139-x7g3jcjm 42 6 , , , cord-265139-x7g3jcjm 42 7 which which WDT cord-265139-x7g3jcjm 42 8 are be VBP cord-265139-x7g3jcjm 42 9 generated generate VBN cord-265139-x7g3jcjm 42 10 only only RB cord-265139-x7g3jcjm 42 11 from from IN cord-265139-x7g3jcjm 42 12 the the DT cord-265139-x7g3jcjm 42 13 exon exon NN cord-265139-x7g3jcjm 42 14 regions region NNS cord-265139-x7g3jcjm 42 15 , , , cord-265139-x7g3jcjm 42 16 account account VBP cord-265139-x7g3jcjm 42 17 for for IN cord-265139-x7g3jcjm 42 18 most most JJS cord-265139-x7g3jcjm 42 19 ( ( -LRB- cord-265139-x7g3jcjm 42 20 over over IN cord-265139-x7g3jcjm 42 21 80 80 CD cord-265139-x7g3jcjm 42 22 % % NN cord-265139-x7g3jcjm 42 23 ) ) -RRB- cord-265139-x7g3jcjm 42 24 known know VBN cord-265139-x7g3jcjm 42 25 circRNAs circrna NNS cord-265139-x7g3jcjm 42 26 , , , cord-265139-x7g3jcjm 42 27 and and CC cord-265139-x7g3jcjm 42 28 are be VBP cord-265139-x7g3jcjm 42 29 found find VBN cord-265139-x7g3jcjm 42 30 mainly mainly RB cord-265139-x7g3jcjm 42 31 in in IN cord-265139-x7g3jcjm 42 32 the the DT cord-265139-x7g3jcjm 42 33 cytoplasm cytoplasm NN cord-265139-x7g3jcjm 42 34 ; ; . cord-265139-x7g3jcjm 43 1 ii ii LS cord-265139-x7g3jcjm 43 2 ) ) -RRB- cord-265139-x7g3jcjm 43 3 circRNAs circRNAs NNP cord-265139-x7g3jcjm 43 4 derived derive VBN cord-265139-x7g3jcjm 43 5 from from IN cord-265139-x7g3jcjm 43 6 lariat lariat NN cord-265139-x7g3jcjm 43 7 introns intron NNS cord-265139-x7g3jcjm 43 8 ( ( -LRB- cord-265139-x7g3jcjm 43 9 ciRNAs ciRNAs NNP cord-265139-x7g3jcjm 43 10 ) ) -RRB- cord-265139-x7g3jcjm 43 11 predominantly predominantly RB cord-265139-x7g3jcjm 43 12 located locate VBN cord-265139-x7g3jcjm 43 13 in in IN cord-265139-x7g3jcjm 43 14 nuclei nucleus NNS cord-265139-x7g3jcjm 43 15 ; ; : cord-265139-x7g3jcjm 43 16 and and CC cord-265139-x7g3jcjm 43 17 iii iii LS cord-265139-x7g3jcjm 43 18 ) ) -RRB- cord-265139-x7g3jcjm 43 19 circRNAs circRNAs NNP cord-265139-x7g3jcjm 43 20 derived derive VBN cord-265139-x7g3jcjm 43 21 from from IN cord-265139-x7g3jcjm 43 22 exons exon NNS cord-265139-x7g3jcjm 43 23 with with IN cord-265139-x7g3jcjm 43 24 retained retain VBN cord-265139-x7g3jcjm 43 25 introns intron NNS cord-265139-x7g3jcjm 43 26 ( ( -LRB- cord-265139-x7g3jcjm 43 27 EIciRNAs EIciRNAs NNP cord-265139-x7g3jcjm 43 28 ) ) -RRB- cord-265139-x7g3jcjm 43 29 and and CC cord-265139-x7g3jcjm 43 30 can can MD cord-265139-x7g3jcjm 43 31 be be VB cord-265139-x7g3jcjm 43 32 mainly mainly RB cord-265139-x7g3jcjm 43 33 found find VBN cord-265139-x7g3jcjm 43 34 in in IN cord-265139-x7g3jcjm 43 35 nuclei nucleus NNS cord-265139-x7g3jcjm 43 36 [ [ -LRB- cord-265139-x7g3jcjm 43 37 10 10 CD cord-265139-x7g3jcjm 43 38 , , , cord-265139-x7g3jcjm 43 39 11 11 CD cord-265139-x7g3jcjm 43 40 , , , cord-265139-x7g3jcjm 43 41 13 13 CD cord-265139-x7g3jcjm 43 42 ] ] -RRB- cord-265139-x7g3jcjm 44 1 ( ( -LRB- cord-265139-x7g3jcjm 44 2 Figure figure NN cord-265139-x7g3jcjm 44 3 1 1 CD cord-265139-x7g3jcjm 44 4 ) ) -RRB- cord-265139-x7g3jcjm 44 5 . . . cord-265139-x7g3jcjm 45 1 Previous previous JJ cord-265139-x7g3jcjm 45 2 analysis analysis NN cord-265139-x7g3jcjm 45 3 of of IN cord-265139-x7g3jcjm 45 4 the the DT cord-265139-x7g3jcjm 45 5 number number NN cord-265139-x7g3jcjm 45 6 of of IN cord-265139-x7g3jcjm 45 7 circRNAs circrna NNS cord-265139-x7g3jcjm 45 8 from from IN cord-265139-x7g3jcjm 45 9 their -PRON- PRP$ cord-265139-x7g3jcjm 45 10 host host NN cord-265139-x7g3jcjm 45 11 genes gene NNS cord-265139-x7g3jcjm 45 12 revealed reveal VBD cord-265139-x7g3jcjm 45 13 that that IN cord-265139-x7g3jcjm 45 14 one one CD cord-265139-x7g3jcjm 45 15 gene gene NN cord-265139-x7g3jcjm 45 16 could could MD cord-265139-x7g3jcjm 45 17 produce produce VB cord-265139-x7g3jcjm 45 18 multiple multiple JJ cord-265139-x7g3jcjm 45 19 circRNA circrna JJ cord-265139-x7g3jcjm 45 20 isoforms isoform NNS cord-265139-x7g3jcjm 45 21 , , , cord-265139-x7g3jcjm 45 22 with with IN cord-265139-x7g3jcjm 45 23 nearly nearly RB cord-265139-x7g3jcjm 45 24 50 50 CD cord-265139-x7g3jcjm 45 25 % % NN cord-265139-x7g3jcjm 45 26 of of IN cord-265139-x7g3jcjm 45 27 the the DT cord-265139-x7g3jcjm 45 28 host host NN cord-265139-x7g3jcjm 45 29 genes gene NNS cord-265139-x7g3jcjm 45 30 expressing express VBG cord-265139-x7g3jcjm 45 31 one one CD cord-265139-x7g3jcjm 45 32 circRNA circrna NN cord-265139-x7g3jcjm 45 33 at at IN cord-265139-x7g3jcjm 45 34 significantly significantly RB cord-265139-x7g3jcjm 45 35 higher high JJR cord-265139-x7g3jcjm 45 36 levels level NNS cord-265139-x7g3jcjm 45 37 [ [ -LRB- cord-265139-x7g3jcjm 45 38 14 14 CD cord-265139-x7g3jcjm 45 39 ] ] -RRB- cord-265139-x7g3jcjm 45 40 . . . cord-265139-x7g3jcjm 46 1 Concerning concern VBG cord-265139-x7g3jcjm 46 2 circRNAs circrnas JJ cord-265139-x7g3jcjm 46 3 turnover turnover NN cord-265139-x7g3jcjm 46 4 , , , cord-265139-x7g3jcjm 46 5 exosomes exosome NNS cord-265139-x7g3jcjm 46 6 have have VBP cord-265139-x7g3jcjm 46 7 been be VBN cord-265139-x7g3jcjm 46 8 proposed propose VBN cord-265139-x7g3jcjm 46 9 as as IN cord-265139-x7g3jcjm 46 10 one one CD cord-265139-x7g3jcjm 46 11 of of IN cord-265139-x7g3jcjm 46 12 the the DT cord-265139-x7g3jcjm 46 13 mechanisms mechanism NNS cord-265139-x7g3jcjm 46 14 by by IN cord-265139-x7g3jcjm 46 15 which which WDT cord-265139-x7g3jcjm 46 16 these these DT cord-265139-x7g3jcjm 46 17 transcripts transcript NNS cord-265139-x7g3jcjm 46 18 might may MD cord-265139-x7g3jcjm 46 19 be be VB cord-265139-x7g3jcjm 46 20 cleared clear VBN cord-265139-x7g3jcjm 46 21 from from IN cord-265139-x7g3jcjm 46 22 the the DT cord-265139-x7g3jcjm 46 23 cell cell NN cord-265139-x7g3jcjm 46 24 [ [ -LRB- cord-265139-x7g3jcjm 46 25 15 15 CD cord-265139-x7g3jcjm 46 26 ] ] -RRB- cord-265139-x7g3jcjm 46 27 , , , cord-265139-x7g3jcjm 46 28 but but CC cord-265139-x7g3jcjm 46 29 further further JJ cord-265139-x7g3jcjm 46 30 studies study NNS cord-265139-x7g3jcjm 46 31 are be VBP cord-265139-x7g3jcjm 46 32 required require VBN cord-265139-x7g3jcjm 46 33 to to TO cord-265139-x7g3jcjm 46 34 explore explore VB cord-265139-x7g3jcjm 46 35 the the DT cord-265139-x7g3jcjm 46 36 regulatory regulatory JJ cord-265139-x7g3jcjm 46 37 factors factor NNS cord-265139-x7g3jcjm 46 38 involved involve VBN cord-265139-x7g3jcjm 46 39 in in IN cord-265139-x7g3jcjm 46 40 the the DT cord-265139-x7g3jcjm 46 41 control control NN cord-265139-x7g3jcjm 46 42 of of IN cord-265139-x7g3jcjm 46 43 circRNAs circrnas JJ cord-265139-x7g3jcjm 46 44 metabolic metabolic JJ cord-265139-x7g3jcjm 46 45 turnover turnover NN cord-265139-x7g3jcjm 46 46 . . . cord-265139-x7g3jcjm 47 1 Pre Pre NNP cord-265139-x7g3jcjm 47 2 - - NN cord-265139-x7g3jcjm 47 3 mRNA mRNA NNP cord-265139-x7g3jcjm 47 4 can can MD cord-265139-x7g3jcjm 47 5 also also RB cord-265139-x7g3jcjm 47 6 be be VB cord-265139-x7g3jcjm 47 7 spliced splice VBN cord-265139-x7g3jcjm 47 8 in in IN cord-265139-x7g3jcjm 47 9 the the DT cord-265139-x7g3jcjm 47 10 noncanonical noncanonical JJ cord-265139-x7g3jcjm 47 11 manner manner NN cord-265139-x7g3jcjm 47 12 " " `` cord-265139-x7g3jcjm 47 13 backsplicing backsplice VBG cord-265139-x7g3jcjm 47 14 " " '' cord-265139-x7g3jcjm 47 15 , , , cord-265139-x7g3jcjm 47 16 wherein wherein WRB cord-265139-x7g3jcjm 47 17 a a DT cord-265139-x7g3jcjm 47 18 downstream downstream JJ cord-265139-x7g3jcjm 47 19 splice splice NN cord-265139-x7g3jcjm 47 20 donor donor NN cord-265139-x7g3jcjm 47 21 site site NN cord-265139-x7g3jcjm 47 22 is be VBZ cord-265139-x7g3jcjm 47 23 joined join VBN cord-265139-x7g3jcjm 47 24 to to IN cord-265139-x7g3jcjm 47 25 an an DT cord-265139-x7g3jcjm 47 26 upstream upstream JJ cord-265139-x7g3jcjm 47 27 splice splice NN cord-265139-x7g3jcjm 47 28 acceptor acceptor NN cord-265139-x7g3jcjm 47 29 site site NN cord-265139-x7g3jcjm 47 30 to to TO cord-265139-x7g3jcjm 47 31 produce produce VB cord-265139-x7g3jcjm 47 32 circular circular JJ cord-265139-x7g3jcjm 47 33 RNA RNA NNP cord-265139-x7g3jcjm 47 34 molecules molecule NNS cord-265139-x7g3jcjm 47 35 . . . cord-265139-x7g3jcjm 48 1 Three three CD cord-265139-x7g3jcjm 48 2 different different JJ cord-265139-x7g3jcjm 48 3 types type NNS cord-265139-x7g3jcjm 48 4 of of IN cord-265139-x7g3jcjm 48 5 circRNAs circrna NNS cord-265139-x7g3jcjm 48 6 can can MD cord-265139-x7g3jcjm 48 7 arise arise VB cord-265139-x7g3jcjm 48 8 from from IN cord-265139-x7g3jcjm 48 9 different different JJ cord-265139-x7g3jcjm 48 10 genomic genomic JJ cord-265139-x7g3jcjm 48 11 positions position NNS cord-265139-x7g3jcjm 48 12 and and CC cord-265139-x7g3jcjm 48 13 combinations combination NNS cord-265139-x7g3jcjm 48 14 , , , cord-265139-x7g3jcjm 48 15 including include VBG cord-265139-x7g3jcjm 48 16 : : : cord-265139-x7g3jcjm 48 17 ( ( -LRB- cord-265139-x7g3jcjm 48 18 1 1 LS cord-265139-x7g3jcjm 48 19 ) ) -RRB- cord-265139-x7g3jcjm 48 20 exonic exonic NNP cord-265139-x7g3jcjm 48 21 circRNAs circRNAs NNP cord-265139-x7g3jcjm 48 22 ( ( -LRB- cord-265139-x7g3jcjm 48 23 EcircRNAs EcircRNAs NNP cord-265139-x7g3jcjm 48 24 ) ) -RRB- cord-265139-x7g3jcjm 48 25 , , , cord-265139-x7g3jcjm 48 26 ( ( -LRB- cord-265139-x7g3jcjm 48 27 2 2 LS cord-265139-x7g3jcjm 48 28 ) ) -RRB- cord-265139-x7g3jcjm 48 29 exon exon NN cord-265139-x7g3jcjm 48 30 - - HYPH cord-265139-x7g3jcjm 48 31 intron intron NN cord-265139-x7g3jcjm 48 32 circRNAs circRNAs NNP cord-265139-x7g3jcjm 48 33 ( ( -LRB- cord-265139-x7g3jcjm 48 34 EIciRNAs EIciRNAs NNP cord-265139-x7g3jcjm 48 35 ) ) -RRB- cord-265139-x7g3jcjm 48 36 , , , cord-265139-x7g3jcjm 48 37 and and CC cord-265139-x7g3jcjm 48 38 ( ( -LRB- cord-265139-x7g3jcjm 48 39 3 3 LS cord-265139-x7g3jcjm 48 40 ) ) -RRB- cord-265139-x7g3jcjm 48 41 circular circular JJ cord-265139-x7g3jcjm 48 42 intronic intronic JJ cord-265139-x7g3jcjm 48 43 RNAs rna NNS cord-265139-x7g3jcjm 48 44 ( ( -LRB- cord-265139-x7g3jcjm 48 45 ciRNAs ciRNAs NNP cord-265139-x7g3jcjm 48 46 ) ) -RRB- cord-265139-x7g3jcjm 48 47 . . . cord-265139-x7g3jcjm 49 1 The the DT cord-265139-x7g3jcjm 49 2 formation formation NN cord-265139-x7g3jcjm 49 3 mechanisms mechanism NNS cord-265139-x7g3jcjm 49 4 and and CC cord-265139-x7g3jcjm 49 5 potential potential JJ cord-265139-x7g3jcjm 49 6 functions function NNS cord-265139-x7g3jcjm 49 7 of of IN cord-265139-x7g3jcjm 49 8 these these DT cord-265139-x7g3jcjm 49 9 circRNA circrna JJ cord-265139-x7g3jcjm 49 10 types type NNS cord-265139-x7g3jcjm 49 11 are be VBP cord-265139-x7g3jcjm 49 12 discussed discuss VBN cord-265139-x7g3jcjm 49 13 in in IN cord-265139-x7g3jcjm 49 14 the the DT cord-265139-x7g3jcjm 49 15 text text NN cord-265139-x7g3jcjm 49 16 . . . cord-265139-x7g3jcjm 50 1 According accord VBG cord-265139-x7g3jcjm 50 2 to to IN cord-265139-x7g3jcjm 50 3 the the DT cord-265139-x7g3jcjm 50 4 published publish VBN cord-265139-x7g3jcjm 50 5 literature literature NN cord-265139-x7g3jcjm 50 6 , , , cord-265139-x7g3jcjm 50 7 circRNAs circrnas JJ cord-265139-x7g3jcjm 50 8 share share NN cord-265139-x7g3jcjm 50 9 several several JJ cord-265139-x7g3jcjm 50 10 features feature NNS cord-265139-x7g3jcjm 50 11 . . . cord-265139-x7g3jcjm 51 1 They -PRON- PRP cord-265139-x7g3jcjm 51 2 are be VBP cord-265139-x7g3jcjm 51 3 highly highly RB cord-265139-x7g3jcjm 51 4 stable stable JJ cord-265139-x7g3jcjm 51 5 in in IN cord-265139-x7g3jcjm 51 6 cells cell NNS cord-265139-x7g3jcjm 51 7 due due IN cord-265139-x7g3jcjm 51 8 to to IN cord-265139-x7g3jcjm 51 9 their -PRON- PRP$ cord-265139-x7g3jcjm 51 10 unique unique JJ cord-265139-x7g3jcjm 51 11 structure structure NN cord-265139-x7g3jcjm 51 12 , , , cord-265139-x7g3jcjm 51 13 and and CC cord-265139-x7g3jcjm 51 14 with with IN cord-265139-x7g3jcjm 51 15 most most JJS cord-265139-x7g3jcjm 51 16 species specie NNS cord-265139-x7g3jcjm 51 17 , , , cord-265139-x7g3jcjm 51 18 the the DT cord-265139-x7g3jcjm 51 19 average average JJ cord-265139-x7g3jcjm 51 20 half half JJ cord-265139-x7g3jcjm 51 21 - - HYPH cord-265139-x7g3jcjm 51 22 life life NN cord-265139-x7g3jcjm 51 23 period period NN cord-265139-x7g3jcjm 51 24 of of IN cord-265139-x7g3jcjm 51 25 these these DT cord-265139-x7g3jcjm 51 26 molecules molecule NNS cord-265139-x7g3jcjm 51 27 is be VBZ cord-265139-x7g3jcjm 51 28 about about RB cord-265139-x7g3jcjm 51 29 48 48 CD cord-265139-x7g3jcjm 51 30 h h NN cord-265139-x7g3jcjm 51 31 which which WDT cord-265139-x7g3jcjm 51 32 is be VBZ cord-265139-x7g3jcjm 51 33 much much RB cord-265139-x7g3jcjm 51 34 longer long JJR cord-265139-x7g3jcjm 51 35 than than IN cord-265139-x7g3jcjm 51 36 that that DT cord-265139-x7g3jcjm 51 37 of of IN cord-265139-x7g3jcjm 51 38 mRNAs mRNAs NNPS cord-265139-x7g3jcjm 51 39 ( ( -LRB- cord-265139-x7g3jcjm 51 40 10 10 CD cord-265139-x7g3jcjm 51 41 h h NN cord-265139-x7g3jcjm 51 42 ) ) -RRB- cord-265139-x7g3jcjm 51 43 [ [ -LRB- cord-265139-x7g3jcjm 51 44 16 16 CD cord-265139-x7g3jcjm 51 45 ] ] -RRB- cord-265139-x7g3jcjm 51 46 . . . cord-265139-x7g3jcjm 52 1 However however RB cord-265139-x7g3jcjm 52 2 , , , cord-265139-x7g3jcjm 52 3 this this DT cord-265139-x7g3jcjm 52 4 may may MD cord-265139-x7g3jcjm 52 5 not not RB cord-265139-x7g3jcjm 52 6 be be VB cord-265139-x7g3jcjm 52 7 the the DT cord-265139-x7g3jcjm 52 8 case case NN cord-265139-x7g3jcjm 52 9 for for IN cord-265139-x7g3jcjm 52 10 exonic exonic NNP cord-265139-x7g3jcjm 52 11 circRNAs circRNAs NNP cord-265139-x7g3jcjm 52 12 in in IN cord-265139-x7g3jcjm 52 13 serum serum NN cord-265139-x7g3jcjm 52 14 , , , cord-265139-x7g3jcjm 52 15 presumably presumably RB cord-265139-x7g3jcjm 52 16 due due IN cord-265139-x7g3jcjm 52 17 to to IN cord-265139-x7g3jcjm 52 18 circulating circulate VBG cord-265139-x7g3jcjm 52 19 RNA RNA NNP cord-265139-x7g3jcjm 52 20 endonucleases endonuclease NNS cord-265139-x7g3jcjm 52 21 . . . cord-265139-x7g3jcjm 53 1 circRNAs circrna NNS cord-265139-x7g3jcjm 53 2 are be VBP cord-265139-x7g3jcjm 53 3 evolutionarily evolutionarily RB cord-265139-x7g3jcjm 53 4 conserved conserve VBN cord-265139-x7g3jcjm 53 5 among among IN cord-265139-x7g3jcjm 53 6 species specie NNS cord-265139-x7g3jcjm 53 7 , , , cord-265139-x7g3jcjm 53 8 diverse diverse JJ cord-265139-x7g3jcjm 53 9 , , , cord-265139-x7g3jcjm 53 10 often often RB cord-265139-x7g3jcjm 53 11 show show VBP cord-265139-x7g3jcjm 53 12 tissue tissue NN cord-265139-x7g3jcjm 53 13 or or CC cord-265139-x7g3jcjm 53 14 development development NN cord-265139-x7g3jcjm 53 15 stage stage NN cord-265139-x7g3jcjm 53 16 - - HYPH cord-265139-x7g3jcjm 53 17 specific specific JJ cord-265139-x7g3jcjm 53 18 expression expression NN cord-265139-x7g3jcjm 53 19 patterns pattern NNS cord-265139-x7g3jcjm 53 20 and and CC cord-265139-x7g3jcjm 53 21 have have VBP cord-265139-x7g3jcjm 53 22 determined determine VBN cord-265139-x7g3jcjm 53 23 subcellular subcellular JJ cord-265139-x7g3jcjm 53 24 localization localization NN cord-265139-x7g3jcjm 53 25 [ [ -LRB- cord-265139-x7g3jcjm 53 26 16 16 CD cord-265139-x7g3jcjm 53 27 ] ] -RRB- cord-265139-x7g3jcjm 53 28 [ [ -LRB- cord-265139-x7g3jcjm 53 29 17 17 CD cord-265139-x7g3jcjm 53 30 ] ] -RRB- cord-265139-x7g3jcjm 53 31 [ [ -LRB- cord-265139-x7g3jcjm 53 32 18 18 CD cord-265139-x7g3jcjm 53 33 ] ] -RRB- cord-265139-x7g3jcjm 53 34 . . . cord-265139-x7g3jcjm 54 1 The the DT cord-265139-x7g3jcjm 54 2 abundance abundance NN cord-265139-x7g3jcjm 54 3 of of IN cord-265139-x7g3jcjm 54 4 circRNAs circrna NNS cord-265139-x7g3jcjm 54 5 relative relative JJ cord-265139-x7g3jcjm 54 6 to to IN cord-265139-x7g3jcjm 54 7 their -PRON- PRP$ cord-265139-x7g3jcjm 54 8 linear linear JJ cord-265139-x7g3jcjm 54 9 RNA RNA NNP cord-265139-x7g3jcjm 54 10 counterparts counterpart NNS cord-265139-x7g3jcjm 54 11 varies vary VBZ cord-265139-x7g3jcjm 54 12 between between IN cord-265139-x7g3jcjm 54 13 cell cell NN cord-265139-x7g3jcjm 54 14 types type NNS cord-265139-x7g3jcjm 54 15 [ [ -LRB- cord-265139-x7g3jcjm 54 16 19 19 CD cord-265139-x7g3jcjm 54 17 ] ] -RRB- cord-265139-x7g3jcjm 54 18 . . . cord-265139-x7g3jcjm 55 1 They -PRON- PRP cord-265139-x7g3jcjm 55 2 are be VBP cord-265139-x7g3jcjm 55 3 abundant abundant JJ cord-265139-x7g3jcjm 55 4 in in IN cord-265139-x7g3jcjm 55 5 exosomes exosome NNS cord-265139-x7g3jcjm 55 6 and and CC cord-265139-x7g3jcjm 55 7 often often RB cord-265139-x7g3jcjm 55 8 found find VBN cord-265139-x7g3jcjm 55 9 in in IN cord-265139-x7g3jcjm 55 10 extracellular extracellular JJ cord-265139-x7g3jcjm 55 11 fluid fluid NN cord-265139-x7g3jcjm 55 12 ( ( -LRB- cord-265139-x7g3jcjm 55 13 like like IN cord-265139-x7g3jcjm 55 14 saliva saliva NN cord-265139-x7g3jcjm 55 15 , , , cord-265139-x7g3jcjm 55 16 blood blood NN cord-265139-x7g3jcjm 55 17 , , , cord-265139-x7g3jcjm 55 18 and and CC cord-265139-x7g3jcjm 55 19 urine urine NN cord-265139-x7g3jcjm 55 20 ) ) -RRB- cord-265139-x7g3jcjm 55 21 with with IN cord-265139-x7g3jcjm 55 22 an an DT cord-265139-x7g3jcjm 55 23 expression expression NN cord-265139-x7g3jcjm 55 24 level level NN cord-265139-x7g3jcjm 55 25 ten ten CD cord-265139-x7g3jcjm 55 26 times time NNS cord-265139-x7g3jcjm 55 27 higher high JJR cord-265139-x7g3jcjm 55 28 than than IN cord-265139-x7g3jcjm 55 29 that that DT cord-265139-x7g3jcjm 55 30 of of IN cord-265139-x7g3jcjm 55 31 linear linear NN cord-265139-x7g3jcjm 55 32 mRNAs mrnas XX cord-265139-x7g3jcjm 55 33 [ [ -LRB- cord-265139-x7g3jcjm 55 34 20 20 CD cord-265139-x7g3jcjm 55 35 ] ] -RRB- cord-265139-x7g3jcjm 55 36 . . . cord-265139-x7g3jcjm 56 1 Their -PRON- PRP$ cord-265139-x7g3jcjm 56 2 size size NN cord-265139-x7g3jcjm 56 3 ranges range VBZ cord-265139-x7g3jcjm 56 4 from from IN cord-265139-x7g3jcjm 56 5 hundreds hundred NNS cord-265139-x7g3jcjm 56 6 to to IN cord-265139-x7g3jcjm 56 7 thousands thousand NNS cord-265139-x7g3jcjm 56 8 of of IN cord-265139-x7g3jcjm 56 9 nucleotides nucleotide NNS cord-265139-x7g3jcjm 56 10 , , , cord-265139-x7g3jcjm 56 11 while while IN cord-265139-x7g3jcjm 56 12 most most JJS cord-265139-x7g3jcjm 56 13 of of IN cord-265139-x7g3jcjm 56 14 these these DT cord-265139-x7g3jcjm 56 15 RNA RNA NNP cord-265139-x7g3jcjm 56 16 species specie NNS cord-265139-x7g3jcjm 56 17 in in IN cord-265139-x7g3jcjm 56 18 mammals mammal NNS cord-265139-x7g3jcjm 56 19 and and CC cord-265139-x7g3jcjm 56 20 plants plant NNS cord-265139-x7g3jcjm 56 21 are be VBP cord-265139-x7g3jcjm 56 22 hundreds hundred NNS cord-265139-x7g3jcjm 56 23 of of IN cord-265139-x7g3jcjm 56 24 nucleotides nucleotide NNS cord-265139-x7g3jcjm 56 25 [ [ -LRB- cord-265139-x7g3jcjm 56 26 16 16 CD cord-265139-x7g3jcjm 56 27 , , , cord-265139-x7g3jcjm 56 28 21 21 CD cord-265139-x7g3jcjm 56 29 ] ] -RRB- cord-265139-x7g3jcjm 56 30 and and CC cord-265139-x7g3jcjm 56 31 usually usually RB cord-265139-x7g3jcjm 56 32 contain contain VBP cord-265139-x7g3jcjm 56 33 between between IN cord-265139-x7g3jcjm 56 34 one one CD cord-265139-x7g3jcjm 56 35 and and CC cord-265139-x7g3jcjm 56 36 five five CD cord-265139-x7g3jcjm 56 37 exons exon NNS cord-265139-x7g3jcjm 56 38 [ [ -LRB- cord-265139-x7g3jcjm 56 39 18 18 CD cord-265139-x7g3jcjm 56 40 ] ] -RRB- cord-265139-x7g3jcjm 56 41 . . . cord-265139-x7g3jcjm 57 1 Although although IN cord-265139-x7g3jcjm 57 2 the the DT cord-265139-x7g3jcjm 57 3 exact exact JJ cord-265139-x7g3jcjm 57 4 function function NN cord-265139-x7g3jcjm 57 5 of of IN cord-265139-x7g3jcjm 57 6 most most JJS cord-265139-x7g3jcjm 57 7 circRNAs circrna NNS cord-265139-x7g3jcjm 57 8 is be VBZ cord-265139-x7g3jcjm 57 9 still still RB cord-265139-x7g3jcjm 57 10 ambiguous ambiguous JJ cord-265139-x7g3jcjm 57 11 , , , cord-265139-x7g3jcjm 57 12 several several JJ cord-265139-x7g3jcjm 57 13 studies study NNS cord-265139-x7g3jcjm 57 14 have have VBP cord-265139-x7g3jcjm 57 15 indicated indicate VBN cord-265139-x7g3jcjm 57 16 that that IN cord-265139-x7g3jcjm 57 17 circRNAs circRNAs NNP cord-265139-x7g3jcjm 57 18 may may MD cord-265139-x7g3jcjm 57 19 control control VB cord-265139-x7g3jcjm 57 20 multiple multiple JJ cord-265139-x7g3jcjm 57 21 biological biological JJ cord-265139-x7g3jcjm 57 22 processes process NNS cord-265139-x7g3jcjm 57 23 via via IN cord-265139-x7g3jcjm 57 24 a a DT cord-265139-x7g3jcjm 57 25 variety variety NN cord-265139-x7g3jcjm 57 26 of of IN cord-265139-x7g3jcjm 57 27 mechanisms mechanism NNS cord-265139-x7g3jcjm 57 28 . . . cord-265139-x7g3jcjm 58 1 They -PRON- PRP cord-265139-x7g3jcjm 58 2 can can MD cord-265139-x7g3jcjm 58 3 serve serve VB cord-265139-x7g3jcjm 58 4 as as IN cord-265139-x7g3jcjm 58 5 miRNA miRNA NNP cord-265139-x7g3jcjm 58 6 sponges sponge NNS cord-265139-x7g3jcjm 58 7 , , , cord-265139-x7g3jcjm 58 8 which which WDT cord-265139-x7g3jcjm 58 9 in in IN cord-265139-x7g3jcjm 58 10 turn turn NN cord-265139-x7g3jcjm 58 11 influence influence NN cord-265139-x7g3jcjm 58 12 target target NN cord-265139-x7g3jcjm 58 13 mRNA mrna NN cord-265139-x7g3jcjm 58 14 translation translation NN cord-265139-x7g3jcjm 58 15 [ [ -LRB- cord-265139-x7g3jcjm 58 16 18 18 CD cord-265139-x7g3jcjm 58 17 , , , cord-265139-x7g3jcjm 58 18 22 22 CD cord-265139-x7g3jcjm 58 19 ] ] -RRB- cord-265139-x7g3jcjm 58 20 . . . cord-265139-x7g3jcjm 59 1 In in IN cord-265139-x7g3jcjm 59 2 other other JJ cord-265139-x7g3jcjm 59 3 words word NNS cord-265139-x7g3jcjm 59 4 , , , cord-265139-x7g3jcjm 59 5 circRNAs circrna VBZ cord-265139-x7g3jcjm 59 6 that that WDT cord-265139-x7g3jcjm 59 7 contain contain VBP cord-265139-x7g3jcjm 59 8 miRNA miRNA NNP cord-265139-x7g3jcjm 59 9 recognition recognition NN cord-265139-x7g3jcjm 59 10 elements element NNS cord-265139-x7g3jcjm 59 11 ( ( -LRB- cord-265139-x7g3jcjm 59 12 MREs mre NNS cord-265139-x7g3jcjm 59 13 ) ) -RRB- cord-265139-x7g3jcjm 59 14 can can MD cord-265139-x7g3jcjm 59 15 interact interact VB cord-265139-x7g3jcjm 59 16 with with IN cord-265139-x7g3jcjm 59 17 miRNAs miRNAs NNP cord-265139-x7g3jcjm 59 18 by by IN cord-265139-x7g3jcjm 59 19 stable stable JJ cord-265139-x7g3jcjm 59 20 complementary complementary JJ cord-265139-x7g3jcjm 59 21 base base NN cord-265139-x7g3jcjm 59 22 pairing pair VBG cord-265139-x7g3jcjm 59 23 [ [ -LRB- cord-265139-x7g3jcjm 59 24 23 23 CD cord-265139-x7g3jcjm 59 25 , , , cord-265139-x7g3jcjm 59 26 24 24 CD cord-265139-x7g3jcjm 59 27 ] ] -RRB- cord-265139-x7g3jcjm 59 28 to to TO cord-265139-x7g3jcjm 59 29 inhibit inhibit VB cord-265139-x7g3jcjm 59 30 their -PRON- PRP$ cord-265139-x7g3jcjm 59 31 activity activity NN cord-265139-x7g3jcjm 59 32 , , , cord-265139-x7g3jcjm 59 33 and and CC cord-265139-x7g3jcjm 59 34 thus thus RB cord-265139-x7g3jcjm 59 35 , , , cord-265139-x7g3jcjm 59 36 effectively effectively RB cord-265139-x7g3jcjm 59 37 alter alter VB cord-265139-x7g3jcjm 59 38 their -PRON- PRP$ cord-265139-x7g3jcjm 59 39 role role NN cord-265139-x7g3jcjm 59 40 in in IN cord-265139-x7g3jcjm 59 41 the the DT cord-265139-x7g3jcjm 59 42 Pre Pre NNP cord-265139-x7g3jcjm 59 43 - - NN cord-265139-x7g3jcjm 59 44 mRNA mRNA NNP cord-265139-x7g3jcjm 59 45 can can MD cord-265139-x7g3jcjm 59 46 also also RB cord-265139-x7g3jcjm 59 47 be be VB cord-265139-x7g3jcjm 59 48 spliced splice VBN cord-265139-x7g3jcjm 59 49 in in IN cord-265139-x7g3jcjm 59 50 the the DT cord-265139-x7g3jcjm 59 51 noncanonical noncanonical JJ cord-265139-x7g3jcjm 59 52 manner manner NN cord-265139-x7g3jcjm 59 53 " " `` cord-265139-x7g3jcjm 59 54 back back NN cord-265139-x7g3jcjm 59 55 - - HYPH cord-265139-x7g3jcjm 59 56 splicing splicing NN cord-265139-x7g3jcjm 59 57 " " '' cord-265139-x7g3jcjm 59 58 , , , cord-265139-x7g3jcjm 59 59 wherein wherein WRB cord-265139-x7g3jcjm 59 60 a a DT cord-265139-x7g3jcjm 59 61 downstream downstream JJ cord-265139-x7g3jcjm 59 62 splice splice NN cord-265139-x7g3jcjm 59 63 donor donor NN cord-265139-x7g3jcjm 59 64 site site NN cord-265139-x7g3jcjm 59 65 is be VBZ cord-265139-x7g3jcjm 59 66 joined join VBN cord-265139-x7g3jcjm 59 67 to to IN cord-265139-x7g3jcjm 59 68 an an DT cord-265139-x7g3jcjm 59 69 upstream upstream JJ cord-265139-x7g3jcjm 59 70 splice splice NN cord-265139-x7g3jcjm 59 71 acceptor acceptor NN cord-265139-x7g3jcjm 59 72 site site NN cord-265139-x7g3jcjm 59 73 to to TO cord-265139-x7g3jcjm 59 74 produce produce VB cord-265139-x7g3jcjm 59 75 circular circular JJ cord-265139-x7g3jcjm 59 76 RNA RNA NNP cord-265139-x7g3jcjm 59 77 molecules molecule NNS cord-265139-x7g3jcjm 59 78 . . . cord-265139-x7g3jcjm 60 1 Three three CD cord-265139-x7g3jcjm 60 2 different different JJ cord-265139-x7g3jcjm 60 3 types type NNS cord-265139-x7g3jcjm 60 4 of of IN cord-265139-x7g3jcjm 60 5 circRNAs circrna NNS cord-265139-x7g3jcjm 60 6 can can MD cord-265139-x7g3jcjm 60 7 arise arise VB cord-265139-x7g3jcjm 60 8 from from IN cord-265139-x7g3jcjm 60 9 different different JJ cord-265139-x7g3jcjm 60 10 genomic genomic JJ cord-265139-x7g3jcjm 60 11 positions position NNS cord-265139-x7g3jcjm 60 12 and and CC cord-265139-x7g3jcjm 60 13 combinations combination NNS cord-265139-x7g3jcjm 60 14 , , , cord-265139-x7g3jcjm 60 15 including include VBG cord-265139-x7g3jcjm 60 16 : : : cord-265139-x7g3jcjm 60 17 ( ( -LRB- cord-265139-x7g3jcjm 60 18 1 1 LS cord-265139-x7g3jcjm 60 19 ) ) -RRB- cord-265139-x7g3jcjm 60 20 exonic exonic NNP cord-265139-x7g3jcjm 60 21 circRNAs circRNAs NNP cord-265139-x7g3jcjm 60 22 ( ( -LRB- cord-265139-x7g3jcjm 60 23 EcircRNAs EcircRNAs NNP cord-265139-x7g3jcjm 60 24 ) ) -RRB- cord-265139-x7g3jcjm 60 25 , , , cord-265139-x7g3jcjm 60 26 ( ( -LRB- cord-265139-x7g3jcjm 60 27 2 2 LS cord-265139-x7g3jcjm 60 28 ) ) -RRB- cord-265139-x7g3jcjm 60 29 exon exon NN cord-265139-x7g3jcjm 60 30 - - HYPH cord-265139-x7g3jcjm 60 31 intron intron NN cord-265139-x7g3jcjm 60 32 circRNAs circRNAs NNP cord-265139-x7g3jcjm 60 33 ( ( -LRB- cord-265139-x7g3jcjm 60 34 EIciRNAs EIciRNAs NNP cord-265139-x7g3jcjm 60 35 ) ) -RRB- cord-265139-x7g3jcjm 60 36 , , , cord-265139-x7g3jcjm 60 37 and and CC cord-265139-x7g3jcjm 60 38 ( ( -LRB- cord-265139-x7g3jcjm 60 39 3 3 LS cord-265139-x7g3jcjm 60 40 ) ) -RRB- cord-265139-x7g3jcjm 60 41 circular circular JJ cord-265139-x7g3jcjm 60 42 intronic intronic JJ cord-265139-x7g3jcjm 60 43 RNAs rna NNS cord-265139-x7g3jcjm 60 44 ( ( -LRB- cord-265139-x7g3jcjm 60 45 ciRNAs ciRNAs NNP cord-265139-x7g3jcjm 60 46 ) ) -RRB- cord-265139-x7g3jcjm 60 47 . . . cord-265139-x7g3jcjm 61 1 The the DT cord-265139-x7g3jcjm 61 2 formation formation NN cord-265139-x7g3jcjm 61 3 mechanisms mechanism NNS cord-265139-x7g3jcjm 61 4 and and CC cord-265139-x7g3jcjm 61 5 potential potential JJ cord-265139-x7g3jcjm 61 6 functions function NNS cord-265139-x7g3jcjm 61 7 of of IN cord-265139-x7g3jcjm 61 8 these these DT cord-265139-x7g3jcjm 61 9 circRNA circrna JJ cord-265139-x7g3jcjm 61 10 types type NNS cord-265139-x7g3jcjm 61 11 are be VBP cord-265139-x7g3jcjm 61 12 discussed discuss VBN cord-265139-x7g3jcjm 61 13 in in IN cord-265139-x7g3jcjm 61 14 the the DT cord-265139-x7g3jcjm 61 15 text text NN cord-265139-x7g3jcjm 61 16 . . . cord-265139-x7g3jcjm 62 1 According accord VBG cord-265139-x7g3jcjm 62 2 to to IN cord-265139-x7g3jcjm 62 3 the the DT cord-265139-x7g3jcjm 62 4 published publish VBN cord-265139-x7g3jcjm 62 5 literature literature NN cord-265139-x7g3jcjm 62 6 , , , cord-265139-x7g3jcjm 62 7 circRNAs circrnas JJ cord-265139-x7g3jcjm 62 8 share share NN cord-265139-x7g3jcjm 62 9 several several JJ cord-265139-x7g3jcjm 62 10 features feature NNS cord-265139-x7g3jcjm 62 11 . . . cord-265139-x7g3jcjm 63 1 They -PRON- PRP cord-265139-x7g3jcjm 63 2 are be VBP cord-265139-x7g3jcjm 63 3 highly highly RB cord-265139-x7g3jcjm 63 4 stable stable JJ cord-265139-x7g3jcjm 63 5 in in IN cord-265139-x7g3jcjm 63 6 cells cell NNS cord-265139-x7g3jcjm 63 7 due due IN cord-265139-x7g3jcjm 63 8 to to IN cord-265139-x7g3jcjm 63 9 their -PRON- PRP$ cord-265139-x7g3jcjm 63 10 unique unique JJ cord-265139-x7g3jcjm 63 11 structure structure NN cord-265139-x7g3jcjm 63 12 , , , cord-265139-x7g3jcjm 63 13 and and CC cord-265139-x7g3jcjm 63 14 with with IN cord-265139-x7g3jcjm 63 15 most most JJS cord-265139-x7g3jcjm 63 16 species specie NNS cord-265139-x7g3jcjm 63 17 , , , cord-265139-x7g3jcjm 63 18 the the DT cord-265139-x7g3jcjm 63 19 average average JJ cord-265139-x7g3jcjm 63 20 half half JJ cord-265139-x7g3jcjm 63 21 - - HYPH cord-265139-x7g3jcjm 63 22 life life NN cord-265139-x7g3jcjm 63 23 period period NN cord-265139-x7g3jcjm 63 24 of of IN cord-265139-x7g3jcjm 63 25 these these DT cord-265139-x7g3jcjm 63 26 molecules molecule NNS cord-265139-x7g3jcjm 63 27 is be VBZ cord-265139-x7g3jcjm 63 28 about about RB cord-265139-x7g3jcjm 63 29 48 48 CD cord-265139-x7g3jcjm 63 30 h h NN cord-265139-x7g3jcjm 63 31 which which WDT cord-265139-x7g3jcjm 63 32 is be VBZ cord-265139-x7g3jcjm 63 33 much much RB cord-265139-x7g3jcjm 63 34 longer long JJR cord-265139-x7g3jcjm 63 35 than than IN cord-265139-x7g3jcjm 63 36 that that DT cord-265139-x7g3jcjm 63 37 of of IN cord-265139-x7g3jcjm 63 38 mRNAs mRNAs NNPS cord-265139-x7g3jcjm 63 39 ( ( -LRB- cord-265139-x7g3jcjm 63 40 10 10 CD cord-265139-x7g3jcjm 63 41 h h NN cord-265139-x7g3jcjm 63 42 ) ) -RRB- cord-265139-x7g3jcjm 63 43 [ [ -LRB- cord-265139-x7g3jcjm 63 44 16 16 CD cord-265139-x7g3jcjm 63 45 ] ] -RRB- cord-265139-x7g3jcjm 63 46 . . . cord-265139-x7g3jcjm 64 1 However however RB cord-265139-x7g3jcjm 64 2 , , , cord-265139-x7g3jcjm 64 3 this this DT cord-265139-x7g3jcjm 64 4 may may MD cord-265139-x7g3jcjm 64 5 not not RB cord-265139-x7g3jcjm 64 6 be be VB cord-265139-x7g3jcjm 64 7 the the DT cord-265139-x7g3jcjm 64 8 case case NN cord-265139-x7g3jcjm 64 9 for for IN cord-265139-x7g3jcjm 64 10 exonic exonic NNP cord-265139-x7g3jcjm 64 11 circRNAs circRNAs NNP cord-265139-x7g3jcjm 64 12 in in IN cord-265139-x7g3jcjm 64 13 serum serum NN cord-265139-x7g3jcjm 64 14 , , , cord-265139-x7g3jcjm 64 15 presumably presumably RB cord-265139-x7g3jcjm 64 16 due due IN cord-265139-x7g3jcjm 64 17 to to IN cord-265139-x7g3jcjm 64 18 circulating circulate VBG cord-265139-x7g3jcjm 64 19 RNA RNA NNP cord-265139-x7g3jcjm 64 20 endonucleases endonuclease NNS cord-265139-x7g3jcjm 64 21 . . . cord-265139-x7g3jcjm 65 1 circRNAs circrna NNS cord-265139-x7g3jcjm 65 2 are be VBP cord-265139-x7g3jcjm 65 3 evolutionarily evolutionarily RB cord-265139-x7g3jcjm 65 4 conserved conserve VBN cord-265139-x7g3jcjm 65 5 among among IN cord-265139-x7g3jcjm 65 6 species specie NNS cord-265139-x7g3jcjm 65 7 , , , cord-265139-x7g3jcjm 65 8 diverse diverse JJ cord-265139-x7g3jcjm 65 9 , , , cord-265139-x7g3jcjm 65 10 often often RB cord-265139-x7g3jcjm 65 11 show show VBP cord-265139-x7g3jcjm 65 12 tissue tissue NN cord-265139-x7g3jcjm 65 13 or or CC cord-265139-x7g3jcjm 65 14 development development NN cord-265139-x7g3jcjm 65 15 stage stage NN cord-265139-x7g3jcjm 65 16 - - HYPH cord-265139-x7g3jcjm 65 17 specific specific JJ cord-265139-x7g3jcjm 65 18 expression expression NN cord-265139-x7g3jcjm 65 19 patterns pattern NNS cord-265139-x7g3jcjm 65 20 and and CC cord-265139-x7g3jcjm 65 21 have have VBP cord-265139-x7g3jcjm 65 22 determined determine VBN cord-265139-x7g3jcjm 65 23 subcellular subcellular JJ cord-265139-x7g3jcjm 65 24 localization localization NN cord-265139-x7g3jcjm 65 25 [ [ -LRB- cord-265139-x7g3jcjm 65 26 16 16 CD cord-265139-x7g3jcjm 65 27 ] ] -RRB- cord-265139-x7g3jcjm 65 28 [ [ -LRB- cord-265139-x7g3jcjm 65 29 17 17 CD cord-265139-x7g3jcjm 65 30 ] ] -RRB- cord-265139-x7g3jcjm 65 31 [ [ -LRB- cord-265139-x7g3jcjm 65 32 18 18 CD cord-265139-x7g3jcjm 65 33 ] ] -RRB- cord-265139-x7g3jcjm 65 34 . . . cord-265139-x7g3jcjm 66 1 The the DT cord-265139-x7g3jcjm 66 2 abundance abundance NN cord-265139-x7g3jcjm 66 3 of of IN cord-265139-x7g3jcjm 66 4 circRNAs circrna NNS cord-265139-x7g3jcjm 66 5 relative relative JJ cord-265139-x7g3jcjm 66 6 to to IN cord-265139-x7g3jcjm 66 7 their -PRON- PRP$ cord-265139-x7g3jcjm 66 8 linear linear JJ cord-265139-x7g3jcjm 66 9 RNA RNA NNP cord-265139-x7g3jcjm 66 10 counterparts counterpart NNS cord-265139-x7g3jcjm 66 11 varies vary VBZ cord-265139-x7g3jcjm 66 12 between between IN cord-265139-x7g3jcjm 66 13 cell cell NN cord-265139-x7g3jcjm 66 14 types type NNS cord-265139-x7g3jcjm 66 15 [ [ -LRB- cord-265139-x7g3jcjm 66 16 19 19 CD cord-265139-x7g3jcjm 66 17 ] ] -RRB- cord-265139-x7g3jcjm 66 18 . . . cord-265139-x7g3jcjm 67 1 They -PRON- PRP cord-265139-x7g3jcjm 67 2 are be VBP cord-265139-x7g3jcjm 67 3 abundant abundant JJ cord-265139-x7g3jcjm 67 4 in in IN cord-265139-x7g3jcjm 67 5 exosomes exosome NNS cord-265139-x7g3jcjm 67 6 and and CC cord-265139-x7g3jcjm 67 7 often often RB cord-265139-x7g3jcjm 67 8 found find VBN cord-265139-x7g3jcjm 67 9 in in IN cord-265139-x7g3jcjm 67 10 extracellular extracellular JJ cord-265139-x7g3jcjm 67 11 fluid fluid NN cord-265139-x7g3jcjm 67 12 ( ( -LRB- cord-265139-x7g3jcjm 67 13 like like IN cord-265139-x7g3jcjm 67 14 saliva saliva NN cord-265139-x7g3jcjm 67 15 , , , cord-265139-x7g3jcjm 67 16 blood blood NN cord-265139-x7g3jcjm 67 17 , , , cord-265139-x7g3jcjm 67 18 and and CC cord-265139-x7g3jcjm 67 19 urine urine NN cord-265139-x7g3jcjm 67 20 ) ) -RRB- cord-265139-x7g3jcjm 67 21 with with IN cord-265139-x7g3jcjm 67 22 an an DT cord-265139-x7g3jcjm 67 23 expression expression NN cord-265139-x7g3jcjm 67 24 level level NN cord-265139-x7g3jcjm 67 25 ten ten CD cord-265139-x7g3jcjm 67 26 times time NNS cord-265139-x7g3jcjm 67 27 higher high JJR cord-265139-x7g3jcjm 67 28 than than IN cord-265139-x7g3jcjm 67 29 that that DT cord-265139-x7g3jcjm 67 30 of of IN cord-265139-x7g3jcjm 67 31 linear linear NN cord-265139-x7g3jcjm 67 32 mRNAs mrnas XX cord-265139-x7g3jcjm 67 33 [ [ -LRB- cord-265139-x7g3jcjm 67 34 20 20 CD cord-265139-x7g3jcjm 67 35 ] ] -RRB- cord-265139-x7g3jcjm 67 36 . . . cord-265139-x7g3jcjm 68 1 Their -PRON- PRP$ cord-265139-x7g3jcjm 68 2 size size NN cord-265139-x7g3jcjm 68 3 ranges range VBZ cord-265139-x7g3jcjm 68 4 from from IN cord-265139-x7g3jcjm 68 5 hundreds hundred NNS cord-265139-x7g3jcjm 68 6 to to IN cord-265139-x7g3jcjm 68 7 thousands thousand NNS cord-265139-x7g3jcjm 68 8 of of IN cord-265139-x7g3jcjm 68 9 nucleotides nucleotide NNS cord-265139-x7g3jcjm 68 10 , , , cord-265139-x7g3jcjm 68 11 while while IN cord-265139-x7g3jcjm 68 12 most most JJS cord-265139-x7g3jcjm 68 13 of of IN cord-265139-x7g3jcjm 68 14 these these DT cord-265139-x7g3jcjm 68 15 RNA RNA NNP cord-265139-x7g3jcjm 68 16 species specie NNS cord-265139-x7g3jcjm 68 17 in in IN cord-265139-x7g3jcjm 68 18 mammals mammal NNS cord-265139-x7g3jcjm 68 19 and and CC cord-265139-x7g3jcjm 68 20 plants plant NNS cord-265139-x7g3jcjm 68 21 are be VBP cord-265139-x7g3jcjm 68 22 hundreds hundred NNS cord-265139-x7g3jcjm 68 23 of of IN cord-265139-x7g3jcjm 68 24 nucleotides nucleotide NNS cord-265139-x7g3jcjm 68 25 [ [ -LRB- cord-265139-x7g3jcjm 68 26 16 16 CD cord-265139-x7g3jcjm 68 27 , , , cord-265139-x7g3jcjm 68 28 21 21 CD cord-265139-x7g3jcjm 68 29 ] ] -RRB- cord-265139-x7g3jcjm 68 30 and and CC cord-265139-x7g3jcjm 68 31 usually usually RB cord-265139-x7g3jcjm 68 32 contain contain VBP cord-265139-x7g3jcjm 68 33 between between IN cord-265139-x7g3jcjm 68 34 one one CD cord-265139-x7g3jcjm 68 35 and and CC cord-265139-x7g3jcjm 68 36 five five CD cord-265139-x7g3jcjm 68 37 exons exon NNS cord-265139-x7g3jcjm 68 38 [ [ -LRB- cord-265139-x7g3jcjm 68 39 18 18 CD cord-265139-x7g3jcjm 68 40 ] ] -RRB- cord-265139-x7g3jcjm 68 41 . . . cord-265139-x7g3jcjm 69 1 Although although IN cord-265139-x7g3jcjm 69 2 the the DT cord-265139-x7g3jcjm 69 3 exact exact JJ cord-265139-x7g3jcjm 69 4 function function NN cord-265139-x7g3jcjm 69 5 of of IN cord-265139-x7g3jcjm 69 6 most most JJS cord-265139-x7g3jcjm 69 7 circRNAs circrna NNS cord-265139-x7g3jcjm 69 8 is be VBZ cord-265139-x7g3jcjm 69 9 still still RB cord-265139-x7g3jcjm 69 10 ambiguous ambiguous JJ cord-265139-x7g3jcjm 69 11 , , , cord-265139-x7g3jcjm 69 12 several several JJ cord-265139-x7g3jcjm 69 13 studies study NNS cord-265139-x7g3jcjm 69 14 have have VBP cord-265139-x7g3jcjm 69 15 indicated indicate VBN cord-265139-x7g3jcjm 69 16 that that IN cord-265139-x7g3jcjm 69 17 circRNAs circRNAs NNP cord-265139-x7g3jcjm 69 18 may may MD cord-265139-x7g3jcjm 69 19 control control VB cord-265139-x7g3jcjm 69 20 multiple multiple JJ cord-265139-x7g3jcjm 69 21 biological biological JJ cord-265139-x7g3jcjm 69 22 processes process NNS cord-265139-x7g3jcjm 69 23 via via IN cord-265139-x7g3jcjm 69 24 a a DT cord-265139-x7g3jcjm 69 25 variety variety NN cord-265139-x7g3jcjm 69 26 of of IN cord-265139-x7g3jcjm 69 27 mechanisms mechanism NNS cord-265139-x7g3jcjm 69 28 . . . cord-265139-x7g3jcjm 70 1 They -PRON- PRP cord-265139-x7g3jcjm 70 2 can can MD cord-265139-x7g3jcjm 70 3 serve serve VB cord-265139-x7g3jcjm 70 4 as as IN cord-265139-x7g3jcjm 70 5 miRNA miRNA NNP cord-265139-x7g3jcjm 70 6 sponges sponge NNS cord-265139-x7g3jcjm 70 7 , , , cord-265139-x7g3jcjm 70 8 which which WDT cord-265139-x7g3jcjm 70 9 in in IN cord-265139-x7g3jcjm 70 10 turn turn NN cord-265139-x7g3jcjm 70 11 influence influence NN cord-265139-x7g3jcjm 70 12 target target NN cord-265139-x7g3jcjm 70 13 mRNA mrna NN cord-265139-x7g3jcjm 70 14 translation translation NN cord-265139-x7g3jcjm 70 15 [ [ -LRB- cord-265139-x7g3jcjm 70 16 18 18 CD cord-265139-x7g3jcjm 70 17 , , , cord-265139-x7g3jcjm 70 18 22 22 CD cord-265139-x7g3jcjm 70 19 ] ] -RRB- cord-265139-x7g3jcjm 70 20 . . . cord-265139-x7g3jcjm 71 1 In in IN cord-265139-x7g3jcjm 71 2 other other JJ cord-265139-x7g3jcjm 71 3 words word NNS cord-265139-x7g3jcjm 71 4 , , , cord-265139-x7g3jcjm 71 5 circRNAs circrna VBZ cord-265139-x7g3jcjm 71 6 that that WDT cord-265139-x7g3jcjm 71 7 contain contain VBP cord-265139-x7g3jcjm 71 8 miRNA miRNA NNP cord-265139-x7g3jcjm 71 9 recognition recognition NN cord-265139-x7g3jcjm 71 10 elements element NNS cord-265139-x7g3jcjm 71 11 ( ( -LRB- cord-265139-x7g3jcjm 71 12 MREs mre NNS cord-265139-x7g3jcjm 71 13 ) ) -RRB- cord-265139-x7g3jcjm 71 14 can can MD cord-265139-x7g3jcjm 71 15 interact interact VB cord-265139-x7g3jcjm 71 16 with with IN cord-265139-x7g3jcjm 71 17 miRNAs miRNAs NNP cord-265139-x7g3jcjm 71 18 by by IN cord-265139-x7g3jcjm 71 19 stable stable JJ cord-265139-x7g3jcjm 71 20 complementary complementary JJ cord-265139-x7g3jcjm 71 21 base base NN cord-265139-x7g3jcjm 71 22 pairing pair VBG cord-265139-x7g3jcjm 71 23 [ [ -LRB- cord-265139-x7g3jcjm 71 24 23 23 CD cord-265139-x7g3jcjm 71 25 , , , cord-265139-x7g3jcjm 71 26 24 24 CD cord-265139-x7g3jcjm 71 27 ] ] -RRB- cord-265139-x7g3jcjm 71 28 to to TO cord-265139-x7g3jcjm 71 29 inhibit inhibit VB cord-265139-x7g3jcjm 71 30 their -PRON- PRP$ cord-265139-x7g3jcjm 71 31 activity activity NN cord-265139-x7g3jcjm 71 32 , , , cord-265139-x7g3jcjm 71 33 and and CC cord-265139-x7g3jcjm 71 34 thus thus RB cord-265139-x7g3jcjm 71 35 , , , cord-265139-x7g3jcjm 71 36 effectively effectively RB cord-265139-x7g3jcjm 71 37 alter alter VB cord-265139-x7g3jcjm 71 38 their -PRON- PRP$ cord-265139-x7g3jcjm 71 39 role role NN cord-265139-x7g3jcjm 71 40 in in IN cord-265139-x7g3jcjm 71 41 the the DT cord-265139-x7g3jcjm 71 42 posttranscriptional posttranscriptional JJ cord-265139-x7g3jcjm 71 43 regulation regulation NN cord-265139-x7g3jcjm 71 44 of of IN cord-265139-x7g3jcjm 71 45 target target NN cord-265139-x7g3jcjm 71 46 gene gene NN cord-265139-x7g3jcjm 71 47 expression expression NN cord-265139-x7g3jcjm 71 48 . . . cord-265139-x7g3jcjm 72 1 To to TO cord-265139-x7g3jcjm 72 2 cite cite VB cord-265139-x7g3jcjm 72 3 a a DT cord-265139-x7g3jcjm 72 4 few few JJ cord-265139-x7g3jcjm 72 5 examples example NNS cord-265139-x7g3jcjm 72 6 , , , cord-265139-x7g3jcjm 72 7 the the DT cord-265139-x7g3jcjm 72 8 cerebellar cerebellar JJ cord-265139-x7g3jcjm 72 9 degeneration degeneration NN cord-265139-x7g3jcjm 72 10 - - HYPH cord-265139-x7g3jcjm 72 11 related relate VBN cord-265139-x7g3jcjm 72 12 antigen antigen NN cord-265139-x7g3jcjm 72 13 1-antisense 1-antisense CD cord-265139-x7g3jcjm 72 14 circRNA circrna NN cord-265139-x7g3jcjm 72 15 ( ( -LRB- cord-265139-x7g3jcjm 72 16 CDR1as CDR1as NNP cord-265139-x7g3jcjm 72 17 , , , cord-265139-x7g3jcjm 72 18 also also RB cord-265139-x7g3jcjm 72 19 known know VBN cord-265139-x7g3jcjm 72 20 as as IN cord-265139-x7g3jcjm 72 21 ciRS-7 cirs-7 NN cord-265139-x7g3jcjm 72 22 ) ) -RRB- cord-265139-x7g3jcjm 72 23 , , , cord-265139-x7g3jcjm 72 24 which which WDT cord-265139-x7g3jcjm 72 25 is be VBZ cord-265139-x7g3jcjm 72 26 highly highly RB cord-265139-x7g3jcjm 72 27 expressed express VBN cord-265139-x7g3jcjm 72 28 in in IN cord-265139-x7g3jcjm 72 29 the the DT cord-265139-x7g3jcjm 72 30 mammalian mammalian JJ cord-265139-x7g3jcjm 72 31 brain brain NN cord-265139-x7g3jcjm 72 32 and and CC cord-265139-x7g3jcjm 72 33 upregulated upregulate VBN cord-265139-x7g3jcjm 72 34 during during IN cord-265139-x7g3jcjm 72 35 neuronal neuronal JJ cord-265139-x7g3jcjm 72 36 development development NN cord-265139-x7g3jcjm 72 37 [ [ -LRB- cord-265139-x7g3jcjm 72 38 25 25 CD cord-265139-x7g3jcjm 72 39 ] ] -RRB- cord-265139-x7g3jcjm 72 40 , , , cord-265139-x7g3jcjm 72 41 contains contain VBZ cord-265139-x7g3jcjm 72 42 up up IN cord-265139-x7g3jcjm 72 43 to to TO cord-265139-x7g3jcjm 72 44 74 74 CD cord-265139-x7g3jcjm 72 45 binding bind VBG cord-265139-x7g3jcjm 72 46 sites site NNS cord-265139-x7g3jcjm 72 47 for for IN cord-265139-x7g3jcjm 72 48 the the DT cord-265139-x7g3jcjm 72 49 miR-7 miR-7 NNP cord-265139-x7g3jcjm 72 50 and and CC cord-265139-x7g3jcjm 72 51 can can MD cord-265139-x7g3jcjm 72 52 act act VB cord-265139-x7g3jcjm 72 53 as as IN cord-265139-x7g3jcjm 72 54 a a DT cord-265139-x7g3jcjm 72 55 decoy decoy NN cord-265139-x7g3jcjm 72 56 or or CC cord-265139-x7g3jcjm 72 57 sponge sponge NN cord-265139-x7g3jcjm 72 58 for for IN cord-265139-x7g3jcjm 72 59 this this DT cord-265139-x7g3jcjm 72 60 miRNA miRNA NNP cord-265139-x7g3jcjm 72 61 [ [ -LRB- cord-265139-x7g3jcjm 72 62 18 18 CD cord-265139-x7g3jcjm 72 63 ] ] -RRB- cord-265139-x7g3jcjm 72 64 . . . cord-265139-x7g3jcjm 73 1 In in IN cord-265139-x7g3jcjm 73 2 human human JJ cord-265139-x7g3jcjm 73 3 cells cell NNS cord-265139-x7g3jcjm 73 4 , , , cord-265139-x7g3jcjm 73 5 knockdown knockdown NN cord-265139-x7g3jcjm 73 6 of of IN cord-265139-x7g3jcjm 73 7 CDR1as CDR1as NNP cord-265139-x7g3jcjm 73 8 expression expression NN cord-265139-x7g3jcjm 73 9 suppresses suppress VBZ cord-265139-x7g3jcjm 73 10 miR-7 mir-7 NN cord-265139-x7g3jcjm 73 11 expression expression NN cord-265139-x7g3jcjm 73 12 and and CC cord-265139-x7g3jcjm 73 13 affects affect VBZ cord-265139-x7g3jcjm 73 14 insulin insulin NN cord-265139-x7g3jcjm 73 15 secretion secretion NN cord-265139-x7g3jcjm 73 16 , , , cord-265139-x7g3jcjm 73 17 cell cell NN cord-265139-x7g3jcjm 73 18 proliferation proliferation NN cord-265139-x7g3jcjm 73 19 and and CC cord-265139-x7g3jcjm 73 20 the the DT cord-265139-x7g3jcjm 73 21 pathobiology pathobiology NN cord-265139-x7g3jcjm 73 22 of of IN cord-265139-x7g3jcjm 73 23 myocardial myocardial JJ cord-265139-x7g3jcjm 73 24 infarction infarction NN cord-265139-x7g3jcjm 73 25 [ [ -LRB- cord-265139-x7g3jcjm 73 26 26 26 CD cord-265139-x7g3jcjm 73 27 ] ] -RRB- cord-265139-x7g3jcjm 74 1 [ [ -LRB- cord-265139-x7g3jcjm 74 2 27 27 CD cord-265139-x7g3jcjm 74 3 ] ] -RRB- cord-265139-x7g3jcjm 74 4 [ [ -LRB- cord-265139-x7g3jcjm 74 5 28 28 CD cord-265139-x7g3jcjm 74 6 ] ] -RRB- cord-265139-x7g3jcjm 74 7 . . . cord-265139-x7g3jcjm 75 1 Likewise likewise RB cord-265139-x7g3jcjm 75 2 , , , cord-265139-x7g3jcjm 75 3 sex sex NN cord-265139-x7g3jcjm 75 4 determining determining NN cord-265139-x7g3jcjm 75 5 region region NN cord-265139-x7g3jcjm 75 6 Y Y NNP cord-265139-x7g3jcjm 75 7 ( ( -LRB- cord-265139-x7g3jcjm 75 8 SRY)-derived SRY)-derived NNP cord-265139-x7g3jcjm 75 9 circRNA circRNA NNP cord-265139-x7g3jcjm 75 10 ( ( -LRB- cord-265139-x7g3jcjm 75 11 circSRY circSRY NNP cord-265139-x7g3jcjm 75 12 ) ) -RRB- cord-265139-x7g3jcjm 75 13 , , , cord-265139-x7g3jcjm 75 14 which which WDT cord-265139-x7g3jcjm 75 15 is be VBZ cord-265139-x7g3jcjm 75 16 expressed express VBN cord-265139-x7g3jcjm 75 17 in in IN cord-265139-x7g3jcjm 75 18 murine murine JJ cord-265139-x7g3jcjm 75 19 testis testis NN cord-265139-x7g3jcjm 75 20 and and CC cord-265139-x7g3jcjm 75 21 harbors harbor VBZ cord-265139-x7g3jcjm 75 22 16 16 CD cord-265139-x7g3jcjm 75 23 miR-138 mir-138 DT cord-265139-x7g3jcjm 75 24 conserved conserve VBN cord-265139-x7g3jcjm 75 25 binding binding NN cord-265139-x7g3jcjm 75 26 sites site NNS cord-265139-x7g3jcjm 75 27 , , , cord-265139-x7g3jcjm 75 28 has have VBZ cord-265139-x7g3jcjm 75 29 also also RB cord-265139-x7g3jcjm 75 30 been be VBN cord-265139-x7g3jcjm 75 31 shown show VBN cord-265139-x7g3jcjm 75 32 to to TO cord-265139-x7g3jcjm 75 33 act act VB cord-265139-x7g3jcjm 75 34 as as IN cord-265139-x7g3jcjm 75 35 a a DT cord-265139-x7g3jcjm 75 36 miRNA miRNA NNP cord-265139-x7g3jcjm 75 37 sponge sponge NN cord-265139-x7g3jcjm 75 38 [ [ -LRB- cord-265139-x7g3jcjm 75 39 23 23 CD cord-265139-x7g3jcjm 75 40 , , , cord-265139-x7g3jcjm 75 41 24 24 CD cord-265139-x7g3jcjm 75 42 ] ] -RRB- cord-265139-x7g3jcjm 75 43 resulting result VBG cord-265139-x7g3jcjm 75 44 in in IN cord-265139-x7g3jcjm 75 45 gene gene NN cord-265139-x7g3jcjm 75 46 expression expression NN cord-265139-x7g3jcjm 75 47 dysregulation dysregulation NN cord-265139-x7g3jcjm 75 48 . . . cord-265139-x7g3jcjm 76 1 In in IN cord-265139-x7g3jcjm 76 2 addition addition NN cord-265139-x7g3jcjm 76 3 to to IN cord-265139-x7g3jcjm 76 4 circRNAs circrnas VB cord-265139-x7g3jcjm 76 5 found find VBN cord-265139-x7g3jcjm 76 6 in in IN cord-265139-x7g3jcjm 76 7 the the DT cord-265139-x7g3jcjm 76 8 cytoplasm cytoplasm NN cord-265139-x7g3jcjm 76 9 compartment compartment NN cord-265139-x7g3jcjm 76 10 , , , cord-265139-x7g3jcjm 76 11 a a DT cord-265139-x7g3jcjm 76 12 fraction fraction NN cord-265139-x7g3jcjm 76 13 can can MD cord-265139-x7g3jcjm 76 14 accumulate accumulate VB cord-265139-x7g3jcjm 76 15 inside inside IN cord-265139-x7g3jcjm 76 16 the the DT cord-265139-x7g3jcjm 76 17 nucleus nucleus NN cord-265139-x7g3jcjm 76 18 ( ( -LRB- cord-265139-x7g3jcjm 76 19 ciRNAs ciRNAs NNP cord-265139-x7g3jcjm 76 20 and and CC cord-265139-x7g3jcjm 76 21 EIciRNAs EIciRNAs NNP cord-265139-x7g3jcjm 76 22 ) ) -RRB- cord-265139-x7g3jcjm 76 23 where where WRB cord-265139-x7g3jcjm 76 24 they -PRON- PRP cord-265139-x7g3jcjm 76 25 control control VBP cord-265139-x7g3jcjm 76 26 gene gene NN cord-265139-x7g3jcjm 76 27 expression expression NN cord-265139-x7g3jcjm 76 28 at at IN cord-265139-x7g3jcjm 76 29 the the DT cord-265139-x7g3jcjm 76 30 transcriptional transcriptional JJ cord-265139-x7g3jcjm 76 31 level level NN cord-265139-x7g3jcjm 76 32 . . . cord-265139-x7g3jcjm 77 1 These these DT cord-265139-x7g3jcjm 77 2 intron intron NN cord-265139-x7g3jcjm 77 3 - - HYPH cord-265139-x7g3jcjm 77 4 retaining retain VBG cord-265139-x7g3jcjm 77 5 circRNAs circrna NNS cord-265139-x7g3jcjm 77 6 can can MD cord-265139-x7g3jcjm 77 7 interact interact VB cord-265139-x7g3jcjm 77 8 with with IN cord-265139-x7g3jcjm 77 9 upstream upstream JJ cord-265139-x7g3jcjm 77 10 promoters promoter NNS cord-265139-x7g3jcjm 77 11 , , , cord-265139-x7g3jcjm 77 12 RNA RNA NNP cord-265139-x7g3jcjm 77 13 polymerase polymerase NN cord-265139-x7g3jcjm 77 14 II II NNP cord-265139-x7g3jcjm 77 15 ( ( -LRB- cord-265139-x7g3jcjm 77 16 Pol Pol NNP cord-265139-x7g3jcjm 77 17 II II NNP cord-265139-x7g3jcjm 77 18 ) ) -RRB- cord-265139-x7g3jcjm 77 19 , , , cord-265139-x7g3jcjm 77 20 and and CC cord-265139-x7g3jcjm 77 21 other other JJ cord-265139-x7g3jcjm 77 22 proteins protein NNS cord-265139-x7g3jcjm 77 23 of of IN cord-265139-x7g3jcjm 77 24 the the DT cord-265139-x7g3jcjm 77 25 transcription transcription NN cord-265139-x7g3jcjm 77 26 machinery machinery NN cord-265139-x7g3jcjm 77 27 to to TO cord-265139-x7g3jcjm 77 28 regulate regulate VB cord-265139-x7g3jcjm 77 29 their -PRON- PRP$ cord-265139-x7g3jcjm 77 30 parental parental JJ cord-265139-x7g3jcjm 77 31 gene gene NN cord-265139-x7g3jcjm 77 32 expression expression NN cord-265139-x7g3jcjm 77 33 in in IN cord-265139-x7g3jcjm 77 34 some some DT cord-265139-x7g3jcjm 77 35 circumstances circumstance NNS cord-265139-x7g3jcjm 77 36 [ [ -LRB- cord-265139-x7g3jcjm 77 37 29 29 CD cord-265139-x7g3jcjm 77 38 ] ] -RRB- cord-265139-x7g3jcjm 78 1 [ [ -LRB- cord-265139-x7g3jcjm 78 2 30 30 CD cord-265139-x7g3jcjm 78 3 ] ] -RRB- cord-265139-x7g3jcjm 78 4 [ [ -LRB- cord-265139-x7g3jcjm 78 5 31 31 CD cord-265139-x7g3jcjm 78 6 ] ] -RRB- cord-265139-x7g3jcjm 78 7 . . . cord-265139-x7g3jcjm 79 1 For for IN cord-265139-x7g3jcjm 79 2 example example NN cord-265139-x7g3jcjm 79 3 , , , cord-265139-x7g3jcjm 79 4 the the DT cord-265139-x7g3jcjm 79 5 ciRNAs ciRNAs NNP cord-265139-x7g3jcjm 79 6 , , , cord-265139-x7g3jcjm 79 7 ci ci NN cord-265139-x7g3jcjm 79 8 - - HYPH cord-265139-x7g3jcjm 79 9 ANKRD52 ankrd52 NN cord-265139-x7g3jcjm 79 10 and and CC cord-265139-x7g3jcjm 79 11 ci ci NN cord-265139-x7g3jcjm 79 12 - - HYPH cord-265139-x7g3jcjm 79 13 SIRT-7 SIRT-7 NNP cord-265139-x7g3jcjm 79 14 , , , cord-265139-x7g3jcjm 79 15 are be VBP cord-265139-x7g3jcjm 79 16 able able JJ cord-265139-x7g3jcjm 79 17 to to TO cord-265139-x7g3jcjm 79 18 accumulate accumulate VB cord-265139-x7g3jcjm 79 19 at at IN cord-265139-x7g3jcjm 79 20 transcription transcription NN cord-265139-x7g3jcjm 79 21 sites site NNS cord-265139-x7g3jcjm 79 22 and and CC cord-265139-x7g3jcjm 79 23 enhance enhance VB cord-265139-x7g3jcjm 79 24 their -PRON- PRP$ cord-265139-x7g3jcjm 79 25 parental parental JJ cord-265139-x7g3jcjm 79 26 genes gene NNS cord-265139-x7g3jcjm 79 27 expression expression NN cord-265139-x7g3jcjm 79 28 , , , cord-265139-x7g3jcjm 79 29 ankyrin ankyrin NNP cord-265139-x7g3jcjm 79 30 repeat repeat NN cord-265139-x7g3jcjm 79 31 domain domain NN cord-265139-x7g3jcjm 79 32 52 52 CD cord-265139-x7g3jcjm 80 1 ( ( -LRB- cord-265139-x7g3jcjm 80 2 ANKRD52 ankrd52 NN cord-265139-x7g3jcjm 80 3 ) ) -RRB- cord-265139-x7g3jcjm 80 4 and and CC cord-265139-x7g3jcjm 80 5 sirtuin sirtuin NNP cord-265139-x7g3jcjm 80 6 7 7 CD cord-265139-x7g3jcjm 80 7 ( ( -LRB- cord-265139-x7g3jcjm 80 8 RIRT7 RIRT7 NFP cord-265139-x7g3jcjm 80 9 ) ) -RRB- cord-265139-x7g3jcjm 80 10 respectively respectively RB cord-265139-x7g3jcjm 80 11 , , , cord-265139-x7g3jcjm 80 12 through through IN cord-265139-x7g3jcjm 80 13 interaction interaction NN cord-265139-x7g3jcjm 80 14 with with IN cord-265139-x7g3jcjm 80 15 Pol Pol NNP cord-265139-x7g3jcjm 80 16 II II NNP cord-265139-x7g3jcjm 80 17 elongation elongation NN cord-265139-x7g3jcjm 80 18 complex complex NN cord-265139-x7g3jcjm 80 19 [ [ -LRB- cord-265139-x7g3jcjm 80 20 30 30 CD cord-265139-x7g3jcjm 80 21 , , , cord-265139-x7g3jcjm 80 22 32 32 CD cord-265139-x7g3jcjm 80 23 ] ] -RRB- cord-265139-x7g3jcjm 80 24 . . . cord-265139-x7g3jcjm 81 1 circEIF3J circEIF3J NNP cord-265139-x7g3jcjm 81 2 and and CC cord-265139-x7g3jcjm 81 3 circPAIP2 circPAIP2 NNP cord-265139-x7g3jcjm 81 4 , , , cord-265139-x7g3jcjm 81 5 two two CD cord-265139-x7g3jcjm 81 6 exon exon NN cord-265139-x7g3jcjm 81 7 - - HYPH cord-265139-x7g3jcjm 81 8 intron intron NN cord-265139-x7g3jcjm 81 9 circRNAs circrna NNS cord-265139-x7g3jcjm 81 10 , , , cord-265139-x7g3jcjm 81 11 are be VBP cord-265139-x7g3jcjm 81 12 an an DT cord-265139-x7g3jcjm 81 13 additional additional JJ cord-265139-x7g3jcjm 81 14 example example NN cord-265139-x7g3jcjm 81 15 of of IN cord-265139-x7g3jcjm 81 16 circRNAs circrna NNS cord-265139-x7g3jcjm 81 17 exclusively exclusively RB cord-265139-x7g3jcjm 81 18 localized localize VBN cord-265139-x7g3jcjm 81 19 in in IN cord-265139-x7g3jcjm 81 20 the the DT cord-265139-x7g3jcjm 81 21 nucleus nucleus NN cord-265139-x7g3jcjm 81 22 and and CC cord-265139-x7g3jcjm 81 23 able able JJ cord-265139-x7g3jcjm 81 24 to to TO cord-265139-x7g3jcjm 81 25 regulate regulate VB cord-265139-x7g3jcjm 81 26 the the DT cord-265139-x7g3jcjm 81 27 transcription transcription NN cord-265139-x7g3jcjm 81 28 of of IN cord-265139-x7g3jcjm 81 29 their -PRON- PRP$ cord-265139-x7g3jcjm 81 30 parental parental JJ cord-265139-x7g3jcjm 81 31 genes gene NNS cord-265139-x7g3jcjm 81 32 through through IN cord-265139-x7g3jcjm 81 33 interactions interaction NNS cord-265139-x7g3jcjm 81 34 with with IN cord-265139-x7g3jcjm 81 35 U1 U1 NNP cord-265139-x7g3jcjm 81 36 small small JJ cord-265139-x7g3jcjm 81 37 nuclear nuclear JJ cord-265139-x7g3jcjm 81 38 RNA RNA NNP cord-265139-x7g3jcjm 81 39 ( ( -LRB- cord-265139-x7g3jcjm 81 40 snRNA snrna NN cord-265139-x7g3jcjm 81 41 ) ) -RRB- cord-265139-x7g3jcjm 81 42 , , , cord-265139-x7g3jcjm 81 43 Pol Pol NNP cord-265139-x7g3jcjm 81 44 II II NNP cord-265139-x7g3jcjm 81 45 , , , cord-265139-x7g3jcjm 81 46 and and CC cord-265139-x7g3jcjm 81 47 promoter promoter NN cord-265139-x7g3jcjm 81 48 regions region NNS cord-265139-x7g3jcjm 81 49 [ [ -LRB- cord-265139-x7g3jcjm 81 50 29 29 CD cord-265139-x7g3jcjm 81 51 ] ] -RRB- cord-265139-x7g3jcjm 81 52 . . . cord-265139-x7g3jcjm 82 1 In in IN cord-265139-x7g3jcjm 82 2 addition addition NN cord-265139-x7g3jcjm 82 3 , , , cord-265139-x7g3jcjm 82 4 circRNAs circRNAs NNP cord-265139-x7g3jcjm 82 5 may may MD cord-265139-x7g3jcjm 82 6 also also RB cord-265139-x7g3jcjm 82 7 be be VB cord-265139-x7g3jcjm 82 8 implicated implicate VBN cord-265139-x7g3jcjm 82 9 in in IN cord-265139-x7g3jcjm 82 10 alternative alternative JJ cord-265139-x7g3jcjm 82 11 splicing splicing NN cord-265139-x7g3jcjm 82 12 regulating regulating NN cord-265139-x7g3jcjm 82 13 transcription transcription NN cord-265139-x7g3jcjm 82 14 , , , cord-265139-x7g3jcjm 82 15 translation translation NN cord-265139-x7g3jcjm 82 16 , , , cord-265139-x7g3jcjm 82 17 and and CC cord-265139-x7g3jcjm 82 18 miRNA miRNA NNP cord-265139-x7g3jcjm 82 19 levels level NNS cord-265139-x7g3jcjm 82 20 [ [ -LRB- cord-265139-x7g3jcjm 82 21 18 18 CD cord-265139-x7g3jcjm 82 22 ] ] -RRB- cord-265139-x7g3jcjm 82 23 . . . cord-265139-x7g3jcjm 83 1 circRNAs circRNAs NNP cord-265139-x7g3jcjm 83 2 can can MD cord-265139-x7g3jcjm 83 3 also also RB cord-265139-x7g3jcjm 83 4 serve serve VB cord-265139-x7g3jcjm 83 5 as as IN cord-265139-x7g3jcjm 83 6 protein protein NN cord-265139-x7g3jcjm 83 7 decoys decoy NNS cord-265139-x7g3jcjm 83 8 or or CC cord-265139-x7g3jcjm 83 9 antagonists antagonist NNS cord-265139-x7g3jcjm 83 10 to to TO cord-265139-x7g3jcjm 83 11 influence influence VB cord-265139-x7g3jcjm 83 12 gene gene NN cord-265139-x7g3jcjm 83 13 expression expression NN cord-265139-x7g3jcjm 83 14 and and CC cord-265139-x7g3jcjm 83 15 cellular cellular JJ cord-265139-x7g3jcjm 83 16 function function NN cord-265139-x7g3jcjm 83 17 . . . cord-265139-x7g3jcjm 84 1 In in IN cord-265139-x7g3jcjm 84 2 line line NN cord-265139-x7g3jcjm 84 3 with with IN cord-265139-x7g3jcjm 84 4 this this DT cord-265139-x7g3jcjm 84 5 , , , cord-265139-x7g3jcjm 84 6 RNA rna NN cord-265139-x7g3jcjm 84 7 - - HYPH cord-265139-x7g3jcjm 84 8 binding bind VBG cord-265139-x7g3jcjm 84 9 proteins protein NNS cord-265139-x7g3jcjm 84 10 ( ( -LRB- cord-265139-x7g3jcjm 84 11 RBPs RBPs NNP cord-265139-x7g3jcjm 84 12 ) ) -RRB- cord-265139-x7g3jcjm 84 13 harbor harbor VBP cord-265139-x7g3jcjm 84 14 specific specific JJ cord-265139-x7g3jcjm 84 15 sequences sequence NNS cord-265139-x7g3jcjm 84 16 to to TO cord-265139-x7g3jcjm 84 17 bind bind VB cord-265139-x7g3jcjm 84 18 their -PRON- PRP$ cord-265139-x7g3jcjm 84 19 specific specific JJ cord-265139-x7g3jcjm 84 20 RNA RNA NNP cord-265139-x7g3jcjm 84 21 targets target NNS cord-265139-x7g3jcjm 84 22 and and CC cord-265139-x7g3jcjm 84 23 regulate regulate VB cord-265139-x7g3jcjm 84 24 several several JJ cord-265139-x7g3jcjm 84 25 cellular cellular JJ cord-265139-x7g3jcjm 84 26 and and CC cord-265139-x7g3jcjm 84 27 molecular molecular JJ cord-265139-x7g3jcjm 84 28 processes process NNS cord-265139-x7g3jcjm 84 29 [ [ -LRB- cord-265139-x7g3jcjm 84 30 33 33 CD cord-265139-x7g3jcjm 84 31 ] ] -RRB- cord-265139-x7g3jcjm 84 32 . . . cord-265139-x7g3jcjm 85 1 The the DT cord-265139-x7g3jcjm 85 2 interaction interaction NN cord-265139-x7g3jcjm 85 3 between between IN cord-265139-x7g3jcjm 85 4 circRNAs circrna NNS cord-265139-x7g3jcjm 85 5 and and CC cord-265139-x7g3jcjm 85 6 RBPs rbps NN cord-265139-x7g3jcjm 85 7 was be VBD cord-265139-x7g3jcjm 85 8 explored explore VBN cord-265139-x7g3jcjm 85 9 recently recently RB cord-265139-x7g3jcjm 85 10 and and CC cord-265139-x7g3jcjm 85 11 was be VBD cord-265139-x7g3jcjm 85 12 shown show VBN cord-265139-x7g3jcjm 85 13 to to TO cord-265139-x7g3jcjm 85 14 affect affect VB cord-265139-x7g3jcjm 85 15 the the DT cord-265139-x7g3jcjm 85 16 fate fate NN cord-265139-x7g3jcjm 85 17 of of IN cord-265139-x7g3jcjm 85 18 their -PRON- PRP$ cord-265139-x7g3jcjm 85 19 target target NN cord-265139-x7g3jcjm 85 20 mRNAs mRNAs '' cord-265139-x7g3jcjm 85 21 . . . cord-265139-x7g3jcjm 86 1 For for IN cord-265139-x7g3jcjm 86 2 instance instance NN cord-265139-x7g3jcjm 86 3 , , , cord-265139-x7g3jcjm 86 4 circular circular JJ cord-265139-x7g3jcjm 86 5 RNA RNA NNP cord-265139-x7g3jcjm 86 6 poly poly NN cord-265139-x7g3jcjm 86 7 ( ( -LRB- cord-265139-x7g3jcjm 86 8 A a NN cord-265139-x7g3jcjm 86 9 ) ) -RRB- cord-265139-x7g3jcjm 86 10 binding bind VBG cord-265139-x7g3jcjm 86 11 protein protein NN cord-265139-x7g3jcjm 86 12 nuclear nuclear NN cord-265139-x7g3jcjm 86 13 1 1 CD cord-265139-x7g3jcjm 86 14 ( ( -LRB- cord-265139-x7g3jcjm 86 15 circPABPN1 circPABPN1 NNP cord-265139-x7g3jcjm 86 16 ) ) -RRB- cord-265139-x7g3jcjm 86 17 can can MD cord-265139-x7g3jcjm 86 18 recruit recruit VB cord-265139-x7g3jcjm 86 19 the the DT cord-265139-x7g3jcjm 86 20 RBP RBP NNP cord-265139-x7g3jcjm 86 21 Human Human NNP cord-265139-x7g3jcjm 86 22 antigen antigen NN cord-265139-x7g3jcjm 86 23 R r NN cord-265139-x7g3jcjm 86 24 ( ( -LRB- cord-265139-x7g3jcjm 86 25 HuR HuR NNP cord-265139-x7g3jcjm 86 26 ) ) -RRB- cord-265139-x7g3jcjm 86 27 to to TO cord-265139-x7g3jcjm 86 28 suppress suppress VB cord-265139-x7g3jcjm 86 29 its -PRON- PRP$ cord-265139-x7g3jcjm 86 30 interaction interaction NN cord-265139-x7g3jcjm 86 31 with with IN cord-265139-x7g3jcjm 86 32 PABPN1 PABPN1 NNP cord-265139-x7g3jcjm 87 1 mRNA mRNA NNP cord-265139-x7g3jcjm 87 2 , , , cord-265139-x7g3jcjm 87 3 which which WDT cord-265139-x7g3jcjm 87 4 leads lead VBZ cord-265139-x7g3jcjm 87 5 to to IN cord-265139-x7g3jcjm 87 6 reduced reduce VBN cord-265139-x7g3jcjm 87 7 PABPN1 pabpn1 JJ cord-265139-x7g3jcjm 87 8 translation translation NN cord-265139-x7g3jcjm 87 9 [ [ -LRB- cord-265139-x7g3jcjm 87 10 33 33 CD cord-265139-x7g3jcjm 87 11 ] ] -RRB- cord-265139-x7g3jcjm 87 12 . . . cord-265139-x7g3jcjm 88 1 In in IN cord-265139-x7g3jcjm 88 2 vascular vascular JJ cord-265139-x7g3jcjm 88 3 tissue tissue NN cord-265139-x7g3jcjm 88 4 , , , cord-265139-x7g3jcjm 88 5 circular circular JJ cord-265139-x7g3jcjm 88 6 antisense antisense NN cord-265139-x7g3jcjm 88 7 noncoding noncoding NNP cord-265139-x7g3jcjm 88 8 RNA RNA NNP cord-265139-x7g3jcjm 88 9 in in IN cord-265139-x7g3jcjm 88 10 the the DT cord-265139-x7g3jcjm 88 11 INK4 INK4 NNP cord-265139-x7g3jcjm 88 12 locus locus NN cord-265139-x7g3jcjm 88 13 ( ( -LRB- cord-265139-x7g3jcjm 88 14 circANRIL circANRIL NNP cord-265139-x7g3jcjm 88 15 ) ) -RRB- cord-265139-x7g3jcjm 88 16 sequesters sequester VBZ cord-265139-x7g3jcjm 88 17 pescadillo pescadillo NNP cord-265139-x7g3jcjm 88 18 homologue homologue NNP cord-265139-x7g3jcjm 88 19 1 1 CD cord-265139-x7g3jcjm 88 20 ( ( -LRB- cord-265139-x7g3jcjm 88 21 PES1 PES1 NNP cord-265139-x7g3jcjm 88 22 ) ) -RRB- cord-265139-x7g3jcjm 88 23 which which WDT cord-265139-x7g3jcjm 88 24 is be VBZ cord-265139-x7g3jcjm 88 25 an an DT cord-265139-x7g3jcjm 88 26 essential essential JJ cord-265139-x7g3jcjm 88 27 60S 60s CD cord-265139-x7g3jcjm 88 28 - - HYPH cord-265139-x7g3jcjm 88 29 preribosomal preribosomal VBN cord-265139-x7g3jcjm 88 30 assembly assembly NN cord-265139-x7g3jcjm 88 31 factor factor NN cord-265139-x7g3jcjm 88 32 to to TO cord-265139-x7g3jcjm 88 33 impair impair VB cord-265139-x7g3jcjm 88 34 rRNA rrna JJ cord-265139-x7g3jcjm 88 35 maturation maturation NN cord-265139-x7g3jcjm 88 36 , , , cord-265139-x7g3jcjm 88 37 resulting result VBG cord-265139-x7g3jcjm 88 38 in in IN cord-265139-x7g3jcjm 88 39 apoptosis apoptosis NN cord-265139-x7g3jcjm 88 40 [ [ -LRB- cord-265139-x7g3jcjm 88 41 34 34 CD cord-265139-x7g3jcjm 88 42 ] ] -RRB- cord-265139-x7g3jcjm 88 43 . . . cord-265139-x7g3jcjm 88 44 circFoxo3 circFoxo3 NNP cord-265139-x7g3jcjm 88 45 interacts interact VBZ cord-265139-x7g3jcjm 88 46 with with IN cord-265139-x7g3jcjm 88 47 p21 p21 NN cord-265139-x7g3jcjm 88 48 and and CC cord-265139-x7g3jcjm 88 49 cyclin cyclin NN cord-265139-x7g3jcjm 88 50 - - HYPH cord-265139-x7g3jcjm 88 51 dependent dependent JJ cord-265139-x7g3jcjm 88 52 kinase kinase NN cord-265139-x7g3jcjm 88 53 ( ( -LRB- cord-265139-x7g3jcjm 88 54 CDK2 CDK2 NNP cord-265139-x7g3jcjm 88 55 ) ) -RRB- cord-265139-x7g3jcjm 88 56 to to TO cord-265139-x7g3jcjm 88 57 form form VB cord-265139-x7g3jcjm 88 58 a a DT cord-265139-x7g3jcjm 88 59 complex complex NN cord-265139-x7g3jcjm 88 60 that that WDT cord-265139-x7g3jcjm 88 61 impacts impact VBZ cord-265139-x7g3jcjm 88 62 cell cell NN cord-265139-x7g3jcjm 88 63 survival survival NN cord-265139-x7g3jcjm 88 64 and and CC cord-265139-x7g3jcjm 88 65 proliferation proliferation NN cord-265139-x7g3jcjm 88 66 [ [ -LRB- cord-265139-x7g3jcjm 88 67 31 31 CD cord-265139-x7g3jcjm 88 68 ] ] -RRB- cord-265139-x7g3jcjm 88 69 . . . cord-265139-x7g3jcjm 89 1 Additionally additionally RB cord-265139-x7g3jcjm 89 2 , , , cord-265139-x7g3jcjm 89 3 several several JJ cord-265139-x7g3jcjm 89 4 circRNAs circrna NNS cord-265139-x7g3jcjm 89 5 have have VBP cord-265139-x7g3jcjm 89 6 been be VBN cord-265139-x7g3jcjm 89 7 shown show VBN cord-265139-x7g3jcjm 89 8 to to TO cord-265139-x7g3jcjm 89 9 bind bind VB cord-265139-x7g3jcjm 89 10 , , , cord-265139-x7g3jcjm 89 11 store store VB cord-265139-x7g3jcjm 89 12 , , , cord-265139-x7g3jcjm 89 13 and and CC cord-265139-x7g3jcjm 89 14 even even RB cord-265139-x7g3jcjm 89 15 insulate insulate VB cord-265139-x7g3jcjm 89 16 RBPs rbp NNS cord-265139-x7g3jcjm 89 17 from from IN cord-265139-x7g3jcjm 89 18 specific specific JJ cord-265139-x7g3jcjm 89 19 subcellular subcellular JJ cord-265139-x7g3jcjm 89 20 sites site NNS cord-265139-x7g3jcjm 89 21 [ [ -LRB- cord-265139-x7g3jcjm 89 22 35 35 CD cord-265139-x7g3jcjm 89 23 ] ] -RRB- cord-265139-x7g3jcjm 89 24 , , , cord-265139-x7g3jcjm 89 25 but but CC cord-265139-x7g3jcjm 89 26 the the DT cord-265139-x7g3jcjm 89 27 exact exact JJ cord-265139-x7g3jcjm 89 28 mechanism mechanism NN cord-265139-x7g3jcjm 89 29 of of IN cord-265139-x7g3jcjm 89 30 dynamic dynamic JJ cord-265139-x7g3jcjm 89 31 interactions interaction NNS cord-265139-x7g3jcjm 89 32 between between IN cord-265139-x7g3jcjm 89 33 circRNA circrna NN cord-265139-x7g3jcjm 89 34 transcripts transcript NNS cord-265139-x7g3jcjm 89 35 and and CC cord-265139-x7g3jcjm 89 36 various various JJ cord-265139-x7g3jcjm 89 37 proteins protein NNS cord-265139-x7g3jcjm 89 38 remains remain VBZ cord-265139-x7g3jcjm 89 39 partially partially RB cord-265139-x7g3jcjm 89 40 explored explore VBN cord-265139-x7g3jcjm 89 41 . . . cord-265139-x7g3jcjm 90 1 Advances advance NNS cord-265139-x7g3jcjm 90 2 in in IN cord-265139-x7g3jcjm 90 3 this this DT cord-265139-x7g3jcjm 90 4 field field NN cord-265139-x7g3jcjm 90 5 may may MD cord-265139-x7g3jcjm 90 6 come come VB cord-265139-x7g3jcjm 90 7 from from IN cord-265139-x7g3jcjm 90 8 the the DT cord-265139-x7g3jcjm 90 9 emergence emergence NN cord-265139-x7g3jcjm 90 10 of of IN cord-265139-x7g3jcjm 90 11 novel novel JJ cord-265139-x7g3jcjm 90 12 high high JJ cord-265139-x7g3jcjm 90 13 - - HYPH cord-265139-x7g3jcjm 90 14 throughput throughput NN cord-265139-x7g3jcjm 90 15 experimental experimental JJ cord-265139-x7g3jcjm 90 16 technologies technology NNS cord-265139-x7g3jcjm 90 17 and and CC cord-265139-x7g3jcjm 90 18 innovative innovative JJ cord-265139-x7g3jcjm 90 19 machine machine NN cord-265139-x7g3jcjm 90 20 learning learning NN cord-265139-x7g3jcjm 90 21 models model NNS cord-265139-x7g3jcjm 90 22 for for IN cord-265139-x7g3jcjm 90 23 predicting predict VBG cord-265139-x7g3jcjm 90 24 RBP rbp NN cord-265139-x7g3jcjm 90 25 - - HYPH cord-265139-x7g3jcjm 90 26 binding bind VBG cord-265139-x7g3jcjm 90 27 sites site NNS cord-265139-x7g3jcjm 90 28 on on IN cord-265139-x7g3jcjm 90 29 RNAs rna NNS cord-265139-x7g3jcjm 90 30 . . . cord-265139-x7g3jcjm 91 1 In in IN cord-265139-x7g3jcjm 91 2 this this DT cord-265139-x7g3jcjm 91 3 context context NN cord-265139-x7g3jcjm 91 4 , , , cord-265139-x7g3jcjm 91 5 a a DT cord-265139-x7g3jcjm 91 6 new new JJ cord-265139-x7g3jcjm 91 7 computational computational JJ cord-265139-x7g3jcjm 91 8 model model NN cord-265139-x7g3jcjm 91 9 designated designate VBN cord-265139-x7g3jcjm 91 10 CircSLNN CircSLNN NNP cord-265139-x7g3jcjm 91 11 is be VBZ cord-265139-x7g3jcjm 91 12 now now RB cord-265139-x7g3jcjm 91 13 available available JJ cord-265139-x7g3jcjm 91 14 to to TO cord-265139-x7g3jcjm 91 15 predict predict VB cord-265139-x7g3jcjm 91 16 potential potential JJ cord-265139-x7g3jcjm 91 17 RBP rbp NN cord-265139-x7g3jcjm 91 18 sites site NNS cord-265139-x7g3jcjm 91 19 in in IN cord-265139-x7g3jcjm 91 20 circRNA circrna NN cord-265139-x7g3jcjm 91 21 sequences sequence NNS cord-265139-x7g3jcjm 91 22 [ [ -LRB- cord-265139-x7g3jcjm 91 23 36 36 CD cord-265139-x7g3jcjm 91 24 ] ] -RRB- cord-265139-x7g3jcjm 91 25 . . . cord-265139-x7g3jcjm 92 1 Although although IN cord-265139-x7g3jcjm 92 2 circRNAs circrna NNS cord-265139-x7g3jcjm 92 3 have have VBP cord-265139-x7g3jcjm 92 4 been be VBN cord-265139-x7g3jcjm 92 5 defined define VBN cord-265139-x7g3jcjm 92 6 as as IN cord-265139-x7g3jcjm 92 7 a a DT cord-265139-x7g3jcjm 92 8 distinct distinct JJ cord-265139-x7g3jcjm 92 9 class class NN cord-265139-x7g3jcjm 92 10 of of IN cord-265139-x7g3jcjm 92 11 ncRNAs ncrna NNS cord-265139-x7g3jcjm 92 12 that that WDT cord-265139-x7g3jcjm 92 13 do do VBP cord-265139-x7g3jcjm 92 14 not not RB cord-265139-x7g3jcjm 92 15 code code VB cord-265139-x7g3jcjm 92 16 for for IN cord-265139-x7g3jcjm 92 17 proteins protein NNS cord-265139-x7g3jcjm 92 18 , , , cord-265139-x7g3jcjm 92 19 intriguingly intriguingly RB cord-265139-x7g3jcjm 92 20 , , , cord-265139-x7g3jcjm 92 21 recent recent JJ cord-265139-x7g3jcjm 92 22 studies study NNS cord-265139-x7g3jcjm 92 23 have have VBP cord-265139-x7g3jcjm 92 24 indicated indicate VBN cord-265139-x7g3jcjm 92 25 that that IN cord-265139-x7g3jcjm 92 26 some some DT cord-265139-x7g3jcjm 92 27 circRNAs circrna NNS cord-265139-x7g3jcjm 92 28 may may MD cord-265139-x7g3jcjm 92 29 have have VB cord-265139-x7g3jcjm 92 30 an an DT cord-265139-x7g3jcjm 92 31 unexpected unexpected JJ cord-265139-x7g3jcjm 92 32 protein protein NN cord-265139-x7g3jcjm 92 33 - - HYPH cord-265139-x7g3jcjm 92 34 coding code VBG cord-265139-x7g3jcjm 92 35 potential potential NN cord-265139-x7g3jcjm 92 36 [ [ -LRB- cord-265139-x7g3jcjm 92 37 37 37 CD cord-265139-x7g3jcjm 92 38 ] ] -RRB- cord-265139-x7g3jcjm 92 39 , , , cord-265139-x7g3jcjm 92 40 when when WRB cord-265139-x7g3jcjm 92 41 recognized recognize VBN cord-265139-x7g3jcjm 92 42 by by IN cord-265139-x7g3jcjm 92 43 ribosomes ribosome NNS cord-265139-x7g3jcjm 92 44 in in IN cord-265139-x7g3jcjm 92 45 the the DT cord-265139-x7g3jcjm 92 46 presence presence NN cord-265139-x7g3jcjm 92 47 of of IN cord-265139-x7g3jcjm 92 48 internal internal JJ cord-265139-x7g3jcjm 92 49 ribosome ribosome NN cord-265139-x7g3jcjm 92 50 entry entry NN cord-265139-x7g3jcjm 92 51 sites site NNS cord-265139-x7g3jcjm 92 52 ( ( -LRB- cord-265139-x7g3jcjm 92 53 IRESs ires NNS cord-265139-x7g3jcjm 92 54 ) ) -RRB- cord-265139-x7g3jcjm 92 55 [ [ -LRB- cord-265139-x7g3jcjm 92 56 38 38 CD cord-265139-x7g3jcjm 92 57 , , , cord-265139-x7g3jcjm 92 58 39 39 CD cord-265139-x7g3jcjm 92 59 ] ] -RRB- cord-265139-x7g3jcjm 92 60 . . . cord-265139-x7g3jcjm 93 1 Like like IN cord-265139-x7g3jcjm 93 2 lncRNAs lncRNAs NNP cord-265139-x7g3jcjm 93 3 , , , cord-265139-x7g3jcjm 93 4 certain certain JJ cord-265139-x7g3jcjm 93 5 circRNAs circrna NNS cord-265139-x7g3jcjm 93 6 may may MD cord-265139-x7g3jcjm 93 7 contain contain VB cord-265139-x7g3jcjm 93 8 putative putative JJ cord-265139-x7g3jcjm 93 9 short short JJ cord-265139-x7g3jcjm 93 10 open open JJ cord-265139-x7g3jcjm 93 11 reading reading NN cord-265139-x7g3jcjm 93 12 frames frame NNS cord-265139-x7g3jcjm 93 13 ( ( -LRB- cord-265139-x7g3jcjm 93 14 ORFs ORFs NNP cord-265139-x7g3jcjm 93 15 ) ) -RRB- cord-265139-x7g3jcjm 93 16 with with IN cord-265139-x7g3jcjm 93 17 the the DT cord-265139-x7g3jcjm 93 18 capacity capacity NN cord-265139-x7g3jcjm 93 19 to to TO cord-265139-x7g3jcjm 93 20 encode encode VB cord-265139-x7g3jcjm 93 21 small small JJ cord-265139-x7g3jcjm 93 22 peptides peptide NNS cord-265139-x7g3jcjm 93 23 [ [ -LRB- cord-265139-x7g3jcjm 93 24 40 40 CD cord-265139-x7g3jcjm 93 25 ] ] -RRB- cord-265139-x7g3jcjm 93 26 . . . cord-265139-x7g3jcjm 94 1 There there EX cord-265139-x7g3jcjm 94 2 are be VBP cord-265139-x7g3jcjm 94 3 multiple multiple JJ cord-265139-x7g3jcjm 94 4 examples example NNS cord-265139-x7g3jcjm 94 5 in in IN cord-265139-x7g3jcjm 94 6 the the DT cord-265139-x7g3jcjm 94 7 literature literature NN cord-265139-x7g3jcjm 94 8 of of IN cord-265139-x7g3jcjm 94 9 specific specific JJ cord-265139-x7g3jcjm 94 10 circRNAs circrna NNS cord-265139-x7g3jcjm 94 11 that that WDT cord-265139-x7g3jcjm 94 12 can can MD cord-265139-x7g3jcjm 94 13 encode encode VB cord-265139-x7g3jcjm 94 14 peptides peptide NNS cord-265139-x7g3jcjm 94 15 or or CC cord-265139-x7g3jcjm 94 16 proteins protein NNS cord-265139-x7g3jcjm 94 17 . . . cord-265139-x7g3jcjm 95 1 For for IN cord-265139-x7g3jcjm 95 2 instance instance NN cord-265139-x7g3jcjm 95 3 , , , cord-265139-x7g3jcjm 95 4 circ circ XX cord-265139-x7g3jcjm 95 5 - - : cord-265139-x7g3jcjm 95 6 ZNF609 ZNF609 NNP cord-265139-x7g3jcjm 95 7 can can MD cord-265139-x7g3jcjm 95 8 make make VB cord-265139-x7g3jcjm 95 9 a a DT cord-265139-x7g3jcjm 95 10 protein protein NN cord-265139-x7g3jcjm 95 11 functioning function VBG cord-265139-x7g3jcjm 95 12 in in IN cord-265139-x7g3jcjm 95 13 muscle muscle NN cord-265139-x7g3jcjm 95 14 development development NN cord-265139-x7g3jcjm 95 15 [ [ -LRB- cord-265139-x7g3jcjm 95 16 41 41 CD cord-265139-x7g3jcjm 95 17 ] ] -RRB- cord-265139-x7g3jcjm 95 18 . . . cord-265139-x7g3jcjm 96 1 The the DT cord-265139-x7g3jcjm 96 2 circβ circβ NN cord-265139-x7g3jcjm 96 3 - - HYPH cord-265139-x7g3jcjm 96 4 catenin catenin NNS cord-265139-x7g3jcjm 96 5 that that WDT cord-265139-x7g3jcjm 96 6 is be VBZ cord-265139-x7g3jcjm 96 7 derived derive VBN cord-265139-x7g3jcjm 96 8 from from IN cord-265139-x7g3jcjm 96 9 the the DT cord-265139-x7g3jcjm 96 10 β β NNP cord-265139-x7g3jcjm 96 11 - - HYPH cord-265139-x7g3jcjm 96 12 catenin catenin NNP cord-265139-x7g3jcjm 96 13 gene gene NN cord-265139-x7g3jcjm 96 14 has have VBZ cord-265139-x7g3jcjm 96 15 been be VBN cord-265139-x7g3jcjm 96 16 shown show VBN cord-265139-x7g3jcjm 96 17 to to TO cord-265139-x7g3jcjm 96 18 encode encode VB cord-265139-x7g3jcjm 96 19 a a DT cord-265139-x7g3jcjm 96 20 novel novel JJ cord-265139-x7g3jcjm 96 21 370-amino 370-amino CD cord-265139-x7g3jcjm 96 22 acid acid NN cord-265139-x7g3jcjm 96 23 β β NNP cord-265139-x7g3jcjm 96 24 - - HYPH cord-265139-x7g3jcjm 96 25 catenin catenin NNP cord-265139-x7g3jcjm 96 26 isoform isoform NN cord-265139-x7g3jcjm 96 27 [ [ -LRB- cord-265139-x7g3jcjm 96 28 42 42 CD cord-265139-x7g3jcjm 96 29 ] ] -RRB- cord-265139-x7g3jcjm 96 30 . . . cord-265139-x7g3jcjm 97 1 Zhang Zhang NNP cord-265139-x7g3jcjm 97 2 et et NNP cord-265139-x7g3jcjm 97 3 al al NNP cord-265139-x7g3jcjm 97 4 . . NNP cord-265139-x7g3jcjm 97 5 reported report VBD cord-265139-x7g3jcjm 97 6 that that IN cord-265139-x7g3jcjm 97 7 the the DT cord-265139-x7g3jcjm 97 8 circular circular JJ cord-265139-x7g3jcjm 97 9 form form NN cord-265139-x7g3jcjm 97 10 of of IN cord-265139-x7g3jcjm 97 11 LINC LINC NNP cord-265139-x7g3jcjm 97 12 - - HYPH cord-265139-x7g3jcjm 97 13 PINT PINT NNP cord-265139-x7g3jcjm 97 14 ( ( -LRB- cord-265139-x7g3jcjm 97 15 Long Long NNP cord-265139-x7g3jcjm 97 16 Intergenic Intergenic NNP cord-265139-x7g3jcjm 97 17 Non Non NNP cord-265139-x7g3jcjm 97 18 - - NNP cord-265139-x7g3jcjm 97 19 Protein Protein NNP cord-265139-x7g3jcjm 97 20 Coding Coding NNP cord-265139-x7g3jcjm 97 21 RNA RNA NNP cord-265139-x7g3jcjm 97 22 , , , cord-265139-x7g3jcjm 97 23 P53 P53 NNP cord-265139-x7g3jcjm 97 24 Induced Induced NNP cord-265139-x7g3jcjm 97 25 Transcript Transcript NNP cord-265139-x7g3jcjm 97 26 ) ) -RRB- cord-265139-x7g3jcjm 97 27 can can MD cord-265139-x7g3jcjm 97 28 be be VB cord-265139-x7g3jcjm 97 29 translated translate VBN cord-265139-x7g3jcjm 97 30 into into IN cord-265139-x7g3jcjm 97 31 a a DT cord-265139-x7g3jcjm 97 32 small small JJ cord-265139-x7g3jcjm 97 33 peptide peptide NN cord-265139-x7g3jcjm 97 34 to to TO cord-265139-x7g3jcjm 97 35 suppress suppress VB cord-265139-x7g3jcjm 97 36 glioblastoma glioblastoma NN cord-265139-x7g3jcjm 97 37 cell cell NN cord-265139-x7g3jcjm 97 38 proliferation proliferation NN cord-265139-x7g3jcjm 97 39 [ [ -LRB- cord-265139-x7g3jcjm 97 40 43 43 CD cord-265139-x7g3jcjm 97 41 ] ] -RRB- cord-265139-x7g3jcjm 97 42 . . . cord-265139-x7g3jcjm 98 1 However however RB cord-265139-x7g3jcjm 98 2 , , , cord-265139-x7g3jcjm 98 3 in in IN cord-265139-x7g3jcjm 98 4 which which WDT cord-265139-x7g3jcjm 98 5 condition condition NN cord-265139-x7g3jcjm 98 6 is be VBZ cord-265139-x7g3jcjm 98 7 circRNAs circrnas JJ cord-265139-x7g3jcjm 98 8 translation translation NN cord-265139-x7g3jcjm 98 9 prevalent prevalent JJ cord-265139-x7g3jcjm 98 10 and and CC cord-265139-x7g3jcjm 98 11 what what WDT cord-265139-x7g3jcjm 98 12 role role NN cord-265139-x7g3jcjm 98 13 do do VBP cord-265139-x7g3jcjm 98 14 the the DT cord-265139-x7g3jcjm 98 15 putative putative JJ cord-265139-x7g3jcjm 98 16 peptide peptide NN cord-265139-x7g3jcjm 98 17 / / SYM cord-265139-x7g3jcjm 98 18 protein protein NN cord-265139-x7g3jcjm 98 19 products product NNS cord-265139-x7g3jcjm 98 20 play play VBP cord-265139-x7g3jcjm 98 21 are be VBP cord-265139-x7g3jcjm 98 22 important important JJ cord-265139-x7g3jcjm 98 23 questions question NNS cord-265139-x7g3jcjm 98 24 that that WDT cord-265139-x7g3jcjm 98 25 must must MD cord-265139-x7g3jcjm 98 26 be be VB cord-265139-x7g3jcjm 98 27 asked ask VBN cord-265139-x7g3jcjm 98 28 . . . cord-265139-x7g3jcjm 99 1 In in IN cord-265139-x7g3jcjm 99 2 addition addition NN cord-265139-x7g3jcjm 99 3 , , , cord-265139-x7g3jcjm 99 4 even even RB cord-265139-x7g3jcjm 99 5 though though IN cord-265139-x7g3jcjm 99 6 several several JJ cord-265139-x7g3jcjm 99 7 mechanisms mechanism NNS cord-265139-x7g3jcjm 99 8 for for IN cord-265139-x7g3jcjm 99 9 circRNAs circrnas JJ cord-265139-x7g3jcjm 99 10 translation translation NN cord-265139-x7g3jcjm 99 11 have have VBP cord-265139-x7g3jcjm 99 12 been be VBN cord-265139-x7g3jcjm 99 13 proposed propose VBN cord-265139-x7g3jcjm 99 14 [ [ -LRB- cord-265139-x7g3jcjm 99 15 39 39 CD cord-265139-x7g3jcjm 99 16 , , , cord-265139-x7g3jcjm 99 17 43 43 CD cord-265139-x7g3jcjm 99 18 ] ] -RRB- cord-265139-x7g3jcjm 99 19 , , , cord-265139-x7g3jcjm 99 20 further further RB cord-265139-x7g3jcjm 99 21 in in IN cord-265139-x7g3jcjm 99 22 - - HYPH cord-265139-x7g3jcjm 99 23 depth depth NN cord-265139-x7g3jcjm 99 24 studies study NNS cord-265139-x7g3jcjm 99 25 are be VBP cord-265139-x7g3jcjm 99 26 required require VBN cord-265139-x7g3jcjm 99 27 which which WDT cord-265139-x7g3jcjm 99 28 may may MD cord-265139-x7g3jcjm 99 29 help help VB cord-265139-x7g3jcjm 99 30 to to TO cord-265139-x7g3jcjm 99 31 unravel unravel VB cord-265139-x7g3jcjm 99 32 the the DT cord-265139-x7g3jcjm 99 33 mystery mystery NN cord-265139-x7g3jcjm 99 34 of of IN cord-265139-x7g3jcjm 99 35 these these DT cord-265139-x7g3jcjm 99 36 RNAs rna NNS cord-265139-x7g3jcjm 99 37 species specie NNS cord-265139-x7g3jcjm 99 38 . . . cord-265139-x7g3jcjm 100 1 Moreover moreover RB cord-265139-x7g3jcjm 100 2 , , , cord-265139-x7g3jcjm 100 3 if if IN cord-265139-x7g3jcjm 100 4 the the DT cord-265139-x7g3jcjm 100 5 translation translation NN cord-265139-x7g3jcjm 100 6 process process NN cord-265139-x7g3jcjm 100 7 of of IN cord-265139-x7g3jcjm 100 8 circRNAs circRNAs NNP cord-265139-x7g3jcjm 100 9 turns turn VBZ cord-265139-x7g3jcjm 100 10 out out RP cord-265139-x7g3jcjm 100 11 to to TO cord-265139-x7g3jcjm 100 12 be be VB cord-265139-x7g3jcjm 100 13 true true JJ cord-265139-x7g3jcjm 100 14 , , , cord-265139-x7g3jcjm 100 15 this this DT cord-265139-x7g3jcjm 100 16 could could MD cord-265139-x7g3jcjm 100 17 represent represent VB cord-265139-x7g3jcjm 100 18 additional additional JJ cord-265139-x7g3jcjm 100 19 evidence evidence NN cord-265139-x7g3jcjm 100 20 that that IN cord-265139-x7g3jcjm 100 21 these these DT cord-265139-x7g3jcjm 100 22 transcripts transcript NNS cord-265139-x7g3jcjm 100 23 are be VBP cord-265139-x7g3jcjm 100 24 functional functional JJ cord-265139-x7g3jcjm 100 25 molecules molecule NNS cord-265139-x7g3jcjm 100 26 . . . cord-265139-x7g3jcjm 101 1 Such such PDT cord-265139-x7g3jcjm 101 2 a a DT cord-265139-x7g3jcjm 101 3 new new JJ cord-265139-x7g3jcjm 101 4 perspective perspective NN cord-265139-x7g3jcjm 101 5 could could MD cord-265139-x7g3jcjm 101 6 be be VB cord-265139-x7g3jcjm 101 7 considered consider VBN cord-265139-x7g3jcjm 101 8 as as IN cord-265139-x7g3jcjm 101 9 the the DT cord-265139-x7g3jcjm 101 10 first first JJ cord-265139-x7g3jcjm 101 11 step step NN cord-265139-x7g3jcjm 101 12 to to IN cord-265139-x7g3jcjm 101 13 understanding understand VBG cord-265139-x7g3jcjm 101 14 the the DT cord-265139-x7g3jcjm 101 15 hidden hide VBN cord-265139-x7g3jcjm 101 16 human human NN cord-265139-x7g3jcjm 101 17 proteome proteome NN cord-265139-x7g3jcjm 101 18 encoded encode VBN cord-265139-x7g3jcjm 101 19 by by IN cord-265139-x7g3jcjm 101 20 ncRNAs ncRNAs NNP cord-265139-x7g3jcjm 101 21 and and CC cord-265139-x7g3jcjm 101 22 highlight highlight VB cord-265139-x7g3jcjm 101 23 specific specific JJ cord-265139-x7g3jcjm 101 24 avenues avenue NNS cord-265139-x7g3jcjm 101 25 for for IN cord-265139-x7g3jcjm 101 26 future future JJ cord-265139-x7g3jcjm 101 27 research research NN cord-265139-x7g3jcjm 101 28 . . . cord-265139-x7g3jcjm 102 1 In in IN cord-265139-x7g3jcjm 102 2 addition addition NN cord-265139-x7g3jcjm 102 3 to to IN cord-265139-x7g3jcjm 102 4 the the DT cord-265139-x7g3jcjm 102 5 above above RB cord-265139-x7g3jcjm 102 6 - - HYPH cord-265139-x7g3jcjm 102 7 mentioned mention VBN cord-265139-x7g3jcjm 102 8 functions function NNS cord-265139-x7g3jcjm 102 9 , , , cord-265139-x7g3jcjm 102 10 it -PRON- PRP cord-265139-x7g3jcjm 102 11 has have VBZ cord-265139-x7g3jcjm 102 12 been be VBN cord-265139-x7g3jcjm 102 13 suggested suggest VBN cord-265139-x7g3jcjm 102 14 that that IN cord-265139-x7g3jcjm 102 15 circRNAs circrna NNS cord-265139-x7g3jcjm 102 16 found find VBN cord-265139-x7g3jcjm 102 17 in in IN cord-265139-x7g3jcjm 102 18 these these DT cord-265139-x7g3jcjm 102 19 extracellular extracellular JJ cord-265139-x7g3jcjm 102 20 vesicles vesicle NNS cord-265139-x7g3jcjm 102 21 could could MD cord-265139-x7g3jcjm 102 22 serve serve VB cord-265139-x7g3jcjm 102 23 as as IN cord-265139-x7g3jcjm 102 24 essential essential JJ cord-265139-x7g3jcjm 102 25 messengers messenger NNS cord-265139-x7g3jcjm 102 26 for for IN cord-265139-x7g3jcjm 102 27 inter inter JJ cord-265139-x7g3jcjm 102 28 - - JJ cord-265139-x7g3jcjm 102 29 cellular cellular JJ cord-265139-x7g3jcjm 102 30 / / SYM cord-265139-x7g3jcjm 102 31 inter inter JJ cord-265139-x7g3jcjm 102 32 - - JJ cord-265139-x7g3jcjm 102 33 tissue tissue JJ cord-265139-x7g3jcjm 102 34 cross cross NN cord-265139-x7g3jcjm 102 35 - - NN cord-265139-x7g3jcjm 102 36 talk talk NN cord-265139-x7g3jcjm 102 37 as as IN cord-265139-x7g3jcjm 102 38 released release VBN cord-265139-x7g3jcjm 102 39 exosomes exosome NNS cord-265139-x7g3jcjm 102 40 can can MD cord-265139-x7g3jcjm 102 41 be be VB cord-265139-x7g3jcjm 102 42 taken take VBN cord-265139-x7g3jcjm 102 43 up up RP cord-265139-x7g3jcjm 102 44 by by IN cord-265139-x7g3jcjm 102 45 other other JJ cord-265139-x7g3jcjm 102 46 cells cell NNS cord-265139-x7g3jcjm 102 47 [ [ -LRB- cord-265139-x7g3jcjm 102 48 15 15 CD cord-265139-x7g3jcjm 102 49 , , , cord-265139-x7g3jcjm 102 50 44 44 CD cord-265139-x7g3jcjm 102 51 , , , cord-265139-x7g3jcjm 102 52 45 45 CD cord-265139-x7g3jcjm 102 53 ] ] -RRB- cord-265139-x7g3jcjm 102 54 . . . cord-265139-x7g3jcjm 103 1 It -PRON- PRP cord-265139-x7g3jcjm 103 2 has have VBZ cord-265139-x7g3jcjm 103 3 also also RB cord-265139-x7g3jcjm 103 4 been be VBN cord-265139-x7g3jcjm 103 5 indicated indicate VBN cord-265139-x7g3jcjm 103 6 that that IN cord-265139-x7g3jcjm 103 7 circRNA circrna NN cord-265139-x7g3jcjm 103 8 can can MD cord-265139-x7g3jcjm 103 9 serve serve VB cord-265139-x7g3jcjm 103 10 to to TO cord-265139-x7g3jcjm 103 11 protect protect VB cord-265139-x7g3jcjm 103 12 mRNA mrna NN cord-265139-x7g3jcjm 103 13 from from IN cord-265139-x7g3jcjm 103 14 degradation degradation NN cord-265139-x7g3jcjm 103 15 . . . cord-265139-x7g3jcjm 104 1 As as IN cord-265139-x7g3jcjm 104 2 an an DT cord-265139-x7g3jcjm 104 3 example example NN cord-265139-x7g3jcjm 104 4 , , , cord-265139-x7g3jcjm 104 5 a a DT cord-265139-x7g3jcjm 104 6 circRNA circrna NN cord-265139-x7g3jcjm 104 7 named name VBN cord-265139-x7g3jcjm 104 8 circPan3 circPan3 NNP cord-265139-x7g3jcjm 104 9 appears appear VBZ cord-265139-x7g3jcjm 104 10 to to TO cord-265139-x7g3jcjm 104 11 protect protect VB cord-265139-x7g3jcjm 104 12 mRNAs mrnas PRP cord-265139-x7g3jcjm 104 13 encoding encode VBG cord-265139-x7g3jcjm 104 14 the the DT cord-265139-x7g3jcjm 104 15 cytokine cytokine NN cord-265139-x7g3jcjm 104 16 receptor receptor NN cord-265139-x7g3jcjm 104 17 subunit subunit NN cord-265139-x7g3jcjm 104 18 IL-13Rα IL-13Rα NNP cord-265139-x7g3jcjm 104 19 ( ( -LRB- cord-265139-x7g3jcjm 104 20 IL13ral IL13ral NNP cord-265139-x7g3jcjm 104 21 ) ) -RRB- cord-265139-x7g3jcjm 104 22 from from IN cord-265139-x7g3jcjm 104 23 an an DT cord-265139-x7g3jcjm 104 24 mRNA mRNA NNP cord-265139-x7g3jcjm 104 25 decay decay NN cord-265139-x7g3jcjm 104 26 protein protein NN cord-265139-x7g3jcjm 104 27 , , , cord-265139-x7g3jcjm 104 28 K k NN cord-265139-x7g3jcjm 104 29 - - HYPH cord-265139-x7g3jcjm 104 30 homology homology NN cord-265139-x7g3jcjm 104 31 splicing splice VBG cord-265139-x7g3jcjm 104 32 regulatory regulatory JJ cord-265139-x7g3jcjm 104 33 protein protein NN cord-265139-x7g3jcjm 104 34 ( ( -LRB- cord-265139-x7g3jcjm 104 35 KSRP KSRP NNP cord-265139-x7g3jcjm 104 36 ) ) -RRB- cord-265139-x7g3jcjm 104 37 , , , cord-265139-x7g3jcjm 104 38 and and CC cord-265139-x7g3jcjm 104 39 promote promote VB cord-265139-x7g3jcjm 104 40 the the DT cord-265139-x7g3jcjm 104 41 production production NN cord-265139-x7g3jcjm 104 42 of of IN cord-265139-x7g3jcjm 104 43 IL-13Rα1 IL-13Rα1 NNP cord-265139-x7g3jcjm 104 44 in in IN cord-265139-x7g3jcjm 104 45 crypt crypt NN cord-265139-x7g3jcjm 104 46 mouse mouse NN cord-265139-x7g3jcjm 104 47 multipotent multipotent JJ cord-265139-x7g3jcjm 104 48 intestinal intestinal JJ cord-265139-x7g3jcjm 104 49 stem stem NN cord-265139-x7g3jcjm 104 50 cells cell NNS cord-265139-x7g3jcjm 104 51 [ [ -LRB- cord-265139-x7g3jcjm 104 52 46 46 CD cord-265139-x7g3jcjm 104 53 ] ] -RRB- cord-265139-x7g3jcjm 104 54 . . . cord-265139-x7g3jcjm 105 1 Other other JJ cord-265139-x7g3jcjm 105 2 studies study NNS cord-265139-x7g3jcjm 105 3 have have VBP cord-265139-x7g3jcjm 105 4 indicated indicate VBN cord-265139-x7g3jcjm 105 5 that that IN cord-265139-x7g3jcjm 105 6 circRNAs circRNAs NNP cord-265139-x7g3jcjm 105 7 could could MD cord-265139-x7g3jcjm 105 8 play play VB cord-265139-x7g3jcjm 105 9 a a DT cord-265139-x7g3jcjm 105 10 role role NN cord-265139-x7g3jcjm 105 11 in in IN cord-265139-x7g3jcjm 105 12 the the DT cord-265139-x7g3jcjm 105 13 storage storage NN cord-265139-x7g3jcjm 105 14 , , , cord-265139-x7g3jcjm 105 15 sorting sorting NN cord-265139-x7g3jcjm 105 16 , , , cord-265139-x7g3jcjm 105 17 and and CC cord-265139-x7g3jcjm 105 18 localization localization NN cord-265139-x7g3jcjm 105 19 of of IN cord-265139-x7g3jcjm 105 20 miRNAs miRNAs NNP cord-265139-x7g3jcjm 105 21 [ [ -LRB- cord-265139-x7g3jcjm 105 22 47 47 CD cord-265139-x7g3jcjm 105 23 ] ] -RRB- cord-265139-x7g3jcjm 105 24 . . . cord-265139-x7g3jcjm 106 1 Nevertheless nevertheless RB cord-265139-x7g3jcjm 106 2 , , , cord-265139-x7g3jcjm 106 3 despite despite IN cord-265139-x7g3jcjm 106 4 the the DT cord-265139-x7g3jcjm 106 5 significant significant JJ cord-265139-x7g3jcjm 106 6 progress progress NN cord-265139-x7g3jcjm 106 7 toward toward IN cord-265139-x7g3jcjm 106 8 understanding understanding NN cord-265139-x7g3jcjm 106 9 circRNAs circrna VBZ cord-265139-x7g3jcjm 106 10 molecular molecular JJ cord-265139-x7g3jcjm 106 11 biology biology NN cord-265139-x7g3jcjm 106 12 , , , cord-265139-x7g3jcjm 106 13 a a DT cord-265139-x7g3jcjm 106 14 unified unified JJ cord-265139-x7g3jcjm 106 15 explanation explanation NN cord-265139-x7g3jcjm 106 16 for for IN cord-265139-x7g3jcjm 106 17 the the DT cord-265139-x7g3jcjm 106 18 function function NN cord-265139-x7g3jcjm 106 19 of of IN cord-265139-x7g3jcjm 106 20 most most JJS cord-265139-x7g3jcjm 106 21 of of IN cord-265139-x7g3jcjm 106 22 these these DT cord-265139-x7g3jcjm 106 23 RNA RNA NNP cord-265139-x7g3jcjm 106 24 species specie NNS cord-265139-x7g3jcjm 106 25 is be VBZ cord-265139-x7g3jcjm 106 26 still still RB cord-265139-x7g3jcjm 106 27 lacking lack VBG cord-265139-x7g3jcjm 106 28 and and CC cord-265139-x7g3jcjm 106 29 knowledge knowledge NN cord-265139-x7g3jcjm 106 30 of of IN cord-265139-x7g3jcjm 106 31 their -PRON- PRP$ cord-265139-x7g3jcjm 106 32 regulatory regulatory JJ cord-265139-x7g3jcjm 106 33 mechanisms mechanism NNS cord-265139-x7g3jcjm 106 34 remains remain VBZ cord-265139-x7g3jcjm 106 35 rudimentary rudimentary JJ cord-265139-x7g3jcjm 106 36 . . . cord-265139-x7g3jcjm 107 1 Additionally additionally RB cord-265139-x7g3jcjm 107 2 , , , cord-265139-x7g3jcjm 107 3 it -PRON- PRP cord-265139-x7g3jcjm 107 4 is be VBZ cord-265139-x7g3jcjm 107 5 not not RB cord-265139-x7g3jcjm 107 6 known know VBN cord-265139-x7g3jcjm 107 7 how how WRB cord-265139-x7g3jcjm 107 8 circRNAs circrna NNS cord-265139-x7g3jcjm 107 9 are be VBP cord-265139-x7g3jcjm 107 10 retained retain VBN cord-265139-x7g3jcjm 107 11 in in IN cord-265139-x7g3jcjm 107 12 the the DT cord-265139-x7g3jcjm 107 13 nucleus nucleus NN cord-265139-x7g3jcjm 107 14 or or CC cord-265139-x7g3jcjm 107 15 exported export VBN cord-265139-x7g3jcjm 107 16 to to IN cord-265139-x7g3jcjm 107 17 the the DT cord-265139-x7g3jcjm 107 18 cytoplasm cytoplasm NN cord-265139-x7g3jcjm 107 19 . . . cord-265139-x7g3jcjm 108 1 All all PDT cord-265139-x7g3jcjm 108 2 these these DT cord-265139-x7g3jcjm 108 3 limitations limitation NNS cord-265139-x7g3jcjm 108 4 may may MD cord-265139-x7g3jcjm 108 5 slow slow VB cord-265139-x7g3jcjm 108 6 advances advance NNS cord-265139-x7g3jcjm 108 7 to to TO cord-265139-x7g3jcjm 108 8 develop develop VB cord-265139-x7g3jcjm 108 9 circRNAs circrna NNS cord-265139-x7g3jcjm 108 10 as as IN cord-265139-x7g3jcjm 108 11 biomarkers biomarker NNS cord-265139-x7g3jcjm 108 12 and and CC cord-265139-x7g3jcjm 108 13 therapeutic therapeutic JJ cord-265139-x7g3jcjm 108 14 tools tool NNS cord-265139-x7g3jcjm 108 15 for for IN cord-265139-x7g3jcjm 108 16 specific specific JJ cord-265139-x7g3jcjm 108 17 diseases disease NNS cord-265139-x7g3jcjm 108 18 . . . cord-265139-x7g3jcjm 109 1 Although although IN cord-265139-x7g3jcjm 109 2 the the DT cord-265139-x7g3jcjm 109 3 state state NN cord-265139-x7g3jcjm 109 4 of of IN cord-265139-x7g3jcjm 109 5 the the DT cord-265139-x7g3jcjm 109 6 current current JJ cord-265139-x7g3jcjm 109 7 knowledge knowledge NN cord-265139-x7g3jcjm 109 8 of of IN cord-265139-x7g3jcjm 109 9 circRNAs circrnas JJ cord-265139-x7g3jcjm 109 10 biology biology NN cord-265139-x7g3jcjm 109 11 is be VBZ cord-265139-x7g3jcjm 109 12 at at IN cord-265139-x7g3jcjm 109 13 a a DT cord-265139-x7g3jcjm 109 14 very very RB cord-265139-x7g3jcjm 109 15 early early JJ cord-265139-x7g3jcjm 109 16 stage stage NN cord-265139-x7g3jcjm 109 17 , , , cord-265139-x7g3jcjm 109 18 mounting mount VBG cord-265139-x7g3jcjm 109 19 evidence evidence NN cord-265139-x7g3jcjm 109 20 points point NNS cord-265139-x7g3jcjm 109 21 to to IN cord-265139-x7g3jcjm 109 22 their -PRON- PRP$ cord-265139-x7g3jcjm 109 23 role role NN cord-265139-x7g3jcjm 109 24 as as IN cord-265139-x7g3jcjm 109 25 master master NN cord-265139-x7g3jcjm 109 26 regulators regulator NNS cord-265139-x7g3jcjm 109 27 of of IN cord-265139-x7g3jcjm 109 28 gene gene NN cord-265139-x7g3jcjm 109 29 expression expression NN cord-265139-x7g3jcjm 109 30 in in IN cord-265139-x7g3jcjm 109 31 many many JJ cord-265139-x7g3jcjm 109 32 diseases disease NNS cord-265139-x7g3jcjm 109 33 including include VBG cord-265139-x7g3jcjm 109 34 metabolic metabolic JJ cord-265139-x7g3jcjm 109 35 disorders disorder NNS cord-265139-x7g3jcjm 109 36 . . . cord-265139-x7g3jcjm 110 1 In in IN cord-265139-x7g3jcjm 110 2 accordance accordance NN cord-265139-x7g3jcjm 110 3 with with IN cord-265139-x7g3jcjm 110 4 this this DT cord-265139-x7g3jcjm 110 5 observation observation NN cord-265139-x7g3jcjm 110 6 , , , cord-265139-x7g3jcjm 110 7 a a DT cord-265139-x7g3jcjm 110 8 growing grow VBG cord-265139-x7g3jcjm 110 9 number number NN cord-265139-x7g3jcjm 110 10 of of IN cord-265139-x7g3jcjm 110 11 studies study NNS cord-265139-x7g3jcjm 110 12 revealed reveal VBD cord-265139-x7g3jcjm 110 13 the the DT cord-265139-x7g3jcjm 110 14 dysregulation dysregulation NN cord-265139-x7g3jcjm 110 15 of of IN cord-265139-x7g3jcjm 110 16 circRNAs circRNAs NNP cord-265139-x7g3jcjm 110 17 in in IN cord-265139-x7g3jcjm 110 18 association association NN cord-265139-x7g3jcjm 110 19 with with IN cord-265139-x7g3jcjm 110 20 the the DT cord-265139-x7g3jcjm 110 21 pathophysiology pathophysiology NN cord-265139-x7g3jcjm 110 22 of of IN cord-265139-x7g3jcjm 110 23 several several JJ cord-265139-x7g3jcjm 110 24 diseases disease NNS cord-265139-x7g3jcjm 110 25 such such JJ cord-265139-x7g3jcjm 110 26 as as IN cord-265139-x7g3jcjm 110 27 diabetes diabetes NN cord-265139-x7g3jcjm 110 28 , , , cord-265139-x7g3jcjm 110 29 hypertension hypertension NN cord-265139-x7g3jcjm 110 30 , , , cord-265139-x7g3jcjm 110 31 cardiovascular cardiovascular JJ cord-265139-x7g3jcjm 110 32 diseases disease NNS cord-265139-x7g3jcjm 110 33 ( ( -LRB- cord-265139-x7g3jcjm 110 34 CVD CVD NNP cord-265139-x7g3jcjm 110 35 ) ) -RRB- cord-265139-x7g3jcjm 110 36 , , , cord-265139-x7g3jcjm 110 37 and and CC cord-265139-x7g3jcjm 110 38 other other JJ cord-265139-x7g3jcjm 110 39 metabolic metabolic JJ cord-265139-x7g3jcjm 110 40 perturbations perturbation NNS cord-265139-x7g3jcjm 110 41 [ [ -LRB- cord-265139-x7g3jcjm 110 42 48 48 CD cord-265139-x7g3jcjm 110 43 , , , cord-265139-x7g3jcjm 110 44 49 49 CD cord-265139-x7g3jcjm 110 45 ] ] -RRB- cord-265139-x7g3jcjm 110 46 . . . cord-265139-x7g3jcjm 111 1 For for IN cord-265139-x7g3jcjm 111 2 example example NN cord-265139-x7g3jcjm 111 3 , , , cord-265139-x7g3jcjm 111 4 the the DT cord-265139-x7g3jcjm 111 5 aberrant aberrant JJ cord-265139-x7g3jcjm 111 6 expression expression NN cord-265139-x7g3jcjm 111 7 of of IN cord-265139-x7g3jcjm 111 8 certain certain JJ cord-265139-x7g3jcjm 111 9 circRNAs circrna NNS cord-265139-x7g3jcjm 111 10 was be VBD cord-265139-x7g3jcjm 111 11 associated associate VBN cord-265139-x7g3jcjm 111 12 with with IN cord-265139-x7g3jcjm 111 13 the the DT cord-265139-x7g3jcjm 111 14 development development NN cord-265139-x7g3jcjm 111 15 of of IN cord-265139-x7g3jcjm 111 16 diabetes diabete NNS cord-265139-x7g3jcjm 111 17 . . . cord-265139-x7g3jcjm 112 1 In in IN cord-265139-x7g3jcjm 112 2 islet islet NN cord-265139-x7g3jcjm 112 3 cells cell NNS cord-265139-x7g3jcjm 112 4 , , , cord-265139-x7g3jcjm 112 5 the the DT cord-265139-x7g3jcjm 112 6 overexpression overexpression NN cord-265139-x7g3jcjm 112 7 of of IN cord-265139-x7g3jcjm 112 8 CDR1as CDR1as NNP cord-265139-x7g3jcjm 112 9 significantly significantly RB cord-265139-x7g3jcjm 112 10 increased increase VBN cord-265139-x7g3jcjm 112 11 insulin insulin NN cord-265139-x7g3jcjm 112 12 mRNA mrna NN cord-265139-x7g3jcjm 112 13 level level NN cord-265139-x7g3jcjm 112 14 and and CC cord-265139-x7g3jcjm 112 15 granule granule NN cord-265139-x7g3jcjm 112 16 secretion secretion NN cord-265139-x7g3jcjm 112 17 in in IN cord-265139-x7g3jcjm 112 18 β β NN cord-265139-x7g3jcjm 112 19 cells cell NNS cord-265139-x7g3jcjm 112 20 via via IN cord-265139-x7g3jcjm 112 21 CDR1as CDR1as NNP cord-265139-x7g3jcjm 112 22 / / SYM cord-265139-x7g3jcjm 112 23 miR-7 mir-7 NN cord-265139-x7g3jcjm 112 24 pathway pathway NN cord-265139-x7g3jcjm 112 25 [ [ -LRB- cord-265139-x7g3jcjm 112 26 27 27 CD cord-265139-x7g3jcjm 112 27 ] ] -RRB- cord-265139-x7g3jcjm 112 28 . . . cord-265139-x7g3jcjm 113 1 In in IN cord-265139-x7g3jcjm 113 2 heart heart NN cord-265139-x7g3jcjm 113 3 function function NN cord-265139-x7g3jcjm 113 4 , , , cord-265139-x7g3jcjm 113 5 existing exist VBG cord-265139-x7g3jcjm 113 6 evidence evidence NN cord-265139-x7g3jcjm 113 7 showed show VBD cord-265139-x7g3jcjm 113 8 that that IN cord-265139-x7g3jcjm 113 9 the the DT cord-265139-x7g3jcjm 113 10 heart heart NN cord-265139-x7g3jcjm 113 11 - - HYPH cord-265139-x7g3jcjm 113 12 related relate VBN cord-265139-x7g3jcjm 113 13 circRNA circrna NN cord-265139-x7g3jcjm 113 14 ( ( -LRB- cord-265139-x7g3jcjm 113 15 HRCR HRCR NNP cord-265139-x7g3jcjm 113 16 ) ) -RRB- cord-265139-x7g3jcjm 113 17 can can MD cord-265139-x7g3jcjm 113 18 prevent prevent VB cord-265139-x7g3jcjm 113 19 cardiac cardiac JJ cord-265139-x7g3jcjm 113 20 hypertrophy hypertrophy NN cord-265139-x7g3jcjm 113 21 and and CC cord-265139-x7g3jcjm 113 22 heart heart NN cord-265139-x7g3jcjm 113 23 failure failure NN cord-265139-x7g3jcjm 113 24 by by IN cord-265139-x7g3jcjm 113 25 acting act VBG cord-265139-x7g3jcjm 113 26 as as IN cord-265139-x7g3jcjm 113 27 an an DT cord-265139-x7g3jcjm 113 28 endogenous endogenous JJ cord-265139-x7g3jcjm 113 29 sponge sponge NN cord-265139-x7g3jcjm 113 30 for for IN cord-265139-x7g3jcjm 113 31 miR-223 mir-223 NN cord-265139-x7g3jcjm 113 32 [ [ -LRB- cord-265139-x7g3jcjm 113 33 50 50 CD cord-265139-x7g3jcjm 113 34 ] ] -RRB- cord-265139-x7g3jcjm 113 35 . . . cord-265139-x7g3jcjm 114 1 Furthermore furthermore RB cord-265139-x7g3jcjm 114 2 , , , cord-265139-x7g3jcjm 114 3 circRNA circrna JJ cord-265139-x7g3jcjm 114 4 myocardial myocardial JJ cord-265139-x7g3jcjm 114 5 infarction infarction NN cord-265139-x7g3jcjm 114 6 - - HYPH cord-265139-x7g3jcjm 114 7 associated associate VBN cord-265139-x7g3jcjm 114 8 circular circular JJ cord-265139-x7g3jcjm 114 9 RNA RNA NNP cord-265139-x7g3jcjm 114 10 ( ( -LRB- cord-265139-x7g3jcjm 114 11 MICRA MICRA NNP cord-265139-x7g3jcjm 114 12 ) ) -RRB- cord-265139-x7g3jcjm 114 13 showed show VBD cord-265139-x7g3jcjm 114 14 prognostic prognostic JJ cord-265139-x7g3jcjm 114 15 significance significance NN cord-265139-x7g3jcjm 114 16 as as IN cord-265139-x7g3jcjm 114 17 a a DT cord-265139-x7g3jcjm 114 18 biomarker biomarker NN cord-265139-x7g3jcjm 114 19 for for IN cord-265139-x7g3jcjm 114 20 risk risk NN cord-265139-x7g3jcjm 114 21 stratification stratification NN cord-265139-x7g3jcjm 114 22 of of IN cord-265139-x7g3jcjm 114 23 heart heart NN cord-265139-x7g3jcjm 114 24 failure failure NN cord-265139-x7g3jcjm 114 25 after after IN cord-265139-x7g3jcjm 114 26 myocardial myocardial JJ cord-265139-x7g3jcjm 114 27 infarction infarction NN cord-265139-x7g3jcjm 114 28 [ [ -LRB- cord-265139-x7g3jcjm 114 29 51 51 CD cord-265139-x7g3jcjm 114 30 ] ] -RRB- cord-265139-x7g3jcjm 114 31 . . . cord-265139-x7g3jcjm 115 1 circZNF609 circznf609 CD cord-265139-x7g3jcjm 115 2 , , , cord-265139-x7g3jcjm 115 3 one one CD cord-265139-x7g3jcjm 115 4 of of IN cord-265139-x7g3jcjm 115 5 the the DT cord-265139-x7g3jcjm 115 6 abundantly abundantly RB cord-265139-x7g3jcjm 115 7 expressed express VBN cord-265139-x7g3jcjm 115 8 circRNAs circrna NNS cord-265139-x7g3jcjm 115 9 in in IN cord-265139-x7g3jcjm 115 10 endothelial endothelial JJ cord-265139-x7g3jcjm 115 11 cells cell NNS cord-265139-x7g3jcjm 115 12 , , , cord-265139-x7g3jcjm 115 13 was be VBD cord-265139-x7g3jcjm 115 14 significantly significantly RB cord-265139-x7g3jcjm 115 15 upregulated upregulate VBN cord-265139-x7g3jcjm 115 16 upon upon IN cord-265139-x7g3jcjm 115 17 hypoxia hypoxia NN cord-265139-x7g3jcjm 115 18 and and CC cord-265139-x7g3jcjm 115 19 high high JJ cord-265139-x7g3jcjm 115 20 glucose glucose NN cord-265139-x7g3jcjm 115 21 exposure exposure NN cord-265139-x7g3jcjm 115 22 in in IN cord-265139-x7g3jcjm 115 23 vitro vitro FW cord-265139-x7g3jcjm 115 24 , , , cord-265139-x7g3jcjm 115 25 as as RB cord-265139-x7g3jcjm 115 26 well well RB cord-265139-x7g3jcjm 115 27 as as IN cord-265139-x7g3jcjm 115 28 in in IN cord-265139-x7g3jcjm 115 29 patients patient NNS cord-265139-x7g3jcjm 115 30 affected affect VBN cord-265139-x7g3jcjm 115 31 by by IN cord-265139-x7g3jcjm 115 32 diabetes diabetes NN cord-265139-x7g3jcjm 115 33 mellitus mellitus NN cord-265139-x7g3jcjm 115 34 , , , cord-265139-x7g3jcjm 115 35 hypertension hypertension NN cord-265139-x7g3jcjm 115 36 , , , cord-265139-x7g3jcjm 115 37 and and CC cord-265139-x7g3jcjm 115 38 coronary coronary JJ cord-265139-x7g3jcjm 115 39 heart heart NN cord-265139-x7g3jcjm 115 40 disease disease NN cord-265139-x7g3jcjm 115 41 [ [ -LRB- cord-265139-x7g3jcjm 115 42 52 52 CD cord-265139-x7g3jcjm 115 43 , , , cord-265139-x7g3jcjm 115 44 53 53 CD cord-265139-x7g3jcjm 115 45 ] ] -RRB- cord-265139-x7g3jcjm 115 46 . . . cord-265139-x7g3jcjm 116 1 In in IN cord-265139-x7g3jcjm 116 2 atherosclerosis atherosclerosis NN cord-265139-x7g3jcjm 116 3 , , , cord-265139-x7g3jcjm 116 4 CDKN2B CDKN2B NNP cord-265139-x7g3jcjm 116 5 - - HYPH cord-265139-x7g3jcjm 116 6 AS1 AS1 NNP cord-265139-x7g3jcjm 116 7 or or CC cord-265139-x7g3jcjm 116 8 ANRIL ANRIL NNP cord-265139-x7g3jcjm 116 9 is be VBZ cord-265139-x7g3jcjm 116 10 perhaps perhaps RB cord-265139-x7g3jcjm 116 11 one one CD cord-265139-x7g3jcjm 116 12 of of IN cord-265139-x7g3jcjm 116 13 the the DT cord-265139-x7g3jcjm 116 14 molecularly molecularly RB cord-265139-x7g3jcjm 116 15 best well RBS cord-265139-x7g3jcjm 116 16 - - HYPH cord-265139-x7g3jcjm 116 17 studied study VBN cord-265139-x7g3jcjm 116 18 circRNAs circrna NNS cord-265139-x7g3jcjm 116 19 . . . cord-265139-x7g3jcjm 117 1 Based base VBN cord-265139-x7g3jcjm 117 2 on on IN cord-265139-x7g3jcjm 117 3 previous previous JJ cord-265139-x7g3jcjm 117 4 studies study NNS cord-265139-x7g3jcjm 117 5 , , , cord-265139-x7g3jcjm 117 6 circANRIL circANRIL NNP cord-265139-x7g3jcjm 117 7 is be VBZ cord-265139-x7g3jcjm 117 8 an an DT cord-265139-x7g3jcjm 117 9 antisense antisense NN cord-265139-x7g3jcjm 117 10 circRNA circrna NN cord-265139-x7g3jcjm 117 11 generated generate VBN cord-265139-x7g3jcjm 117 12 by by IN cord-265139-x7g3jcjm 117 13 the the DT cord-265139-x7g3jcjm 117 14 9p21 9p21 CD cord-265139-x7g3jcjm 117 15 locus locus NN cord-265139-x7g3jcjm 117 16 , , , cord-265139-x7g3jcjm 117 17 whose whose WP$ cord-265139-x7g3jcjm 117 18 single single JJ cord-265139-x7g3jcjm 117 19 nucleotide nucleotide JJ cord-265139-x7g3jcjm 117 20 polymorphisms polymorphism NNS cord-265139-x7g3jcjm 117 21 ( ( -LRB- cord-265139-x7g3jcjm 117 22 SNPs SNPs NNPS cord-265139-x7g3jcjm 117 23 ) ) -RRB- cord-265139-x7g3jcjm 117 24 have have VBP cord-265139-x7g3jcjm 117 25 been be VBN cord-265139-x7g3jcjm 117 26 linked link VBN cord-265139-x7g3jcjm 117 27 to to IN cord-265139-x7g3jcjm 117 28 genome genome NN cord-265139-x7g3jcjm 117 29 - - HYPH cord-265139-x7g3jcjm 117 30 wide wide JJ cord-265139-x7g3jcjm 117 31 association association NN cord-265139-x7g3jcjm 117 32 studies study NNS cord-265139-x7g3jcjm 117 33 ( ( -LRB- cord-265139-x7g3jcjm 117 34 GWAS GWAS NNP cord-265139-x7g3jcjm 117 35 ) ) -RRB- cord-265139-x7g3jcjm 117 36 on on IN cord-265139-x7g3jcjm 117 37 atherosclerotic atherosclerotic JJ cord-265139-x7g3jcjm 117 38 vascular vascular JJ cord-265139-x7g3jcjm 117 39 disease disease NN cord-265139-x7g3jcjm 117 40 , , , cord-265139-x7g3jcjm 117 41 as as RB cord-265139-x7g3jcjm 117 42 well well RB cord-265139-x7g3jcjm 117 43 as as IN cord-265139-x7g3jcjm 117 44 to to TO cord-265139-x7g3jcjm 117 45 type type VB cord-265139-x7g3jcjm 117 46 2 2 CD cord-265139-x7g3jcjm 117 47 diabetes diabetes NN cord-265139-x7g3jcjm 117 48 mellitus mellitus NN cord-265139-x7g3jcjm 117 49 ( ( -LRB- cord-265139-x7g3jcjm 117 50 T2DM T2DM NNP cord-265139-x7g3jcjm 117 51 ) ) -RRB- cord-265139-x7g3jcjm 117 52 and and CC cord-265139-x7g3jcjm 117 53 other other JJ cord-265139-x7g3jcjm 117 54 diseases disease NNS cord-265139-x7g3jcjm 117 55 [ [ -LRB- cord-265139-x7g3jcjm 117 56 34 34 CD cord-265139-x7g3jcjm 117 57 , , , cord-265139-x7g3jcjm 117 58 54 54 CD cord-265139-x7g3jcjm 117 59 ] ] -RRB- cord-265139-x7g3jcjm 117 60 . . . cord-265139-x7g3jcjm 118 1 Additionally additionally RB cord-265139-x7g3jcjm 118 2 , , , cord-265139-x7g3jcjm 118 3 circANRIL circANRIL NNP cord-265139-x7g3jcjm 118 4 has have VBZ cord-265139-x7g3jcjm 118 5 been be VBN cord-265139-x7g3jcjm 118 6 found find VBN cord-265139-x7g3jcjm 118 7 to to TO cord-265139-x7g3jcjm 118 8 confer confer VB cord-265139-x7g3jcjm 118 9 atheroprotection atheroprotection NN cord-265139-x7g3jcjm 118 10 by by IN cord-265139-x7g3jcjm 118 11 controlling control VBG cord-265139-x7g3jcjm 118 12 rRNA rRNA NNP cord-265139-x7g3jcjm 118 13 maturation maturation NN cord-265139-x7g3jcjm 118 14 and and CC cord-265139-x7g3jcjm 118 15 modulating modulate VBG cord-265139-x7g3jcjm 118 16 pathways pathway NNS cord-265139-x7g3jcjm 118 17 of of IN cord-265139-x7g3jcjm 118 18 atherogenesis atherogenesis NNP cord-265139-x7g3jcjm 118 19 [ [ -LRB- cord-265139-x7g3jcjm 118 20 34 34 CD cord-265139-x7g3jcjm 118 21 ] ] -RRB- cord-265139-x7g3jcjm 118 22 . . . cord-265139-x7g3jcjm 119 1 There there EX cord-265139-x7g3jcjm 119 2 is be VBZ cord-265139-x7g3jcjm 119 3 also also RB cord-265139-x7g3jcjm 119 4 growing grow VBG cord-265139-x7g3jcjm 119 5 evidence evidence NN cord-265139-x7g3jcjm 119 6 that that IN cord-265139-x7g3jcjm 119 7 circRNAs circrna NNS cord-265139-x7g3jcjm 119 8 are be VBP cord-265139-x7g3jcjm 119 9 closely closely RB cord-265139-x7g3jcjm 119 10 linked link VBN cord-265139-x7g3jcjm 119 11 to to IN cord-265139-x7g3jcjm 119 12 non non JJ cord-265139-x7g3jcjm 119 13 - - JJ cord-265139-x7g3jcjm 119 14 alcoholic alcoholic JJ cord-265139-x7g3jcjm 119 15 fatty fatty JJ cord-265139-x7g3jcjm 119 16 liver liver NN cord-265139-x7g3jcjm 119 17 disease disease NN cord-265139-x7g3jcjm 119 18 ( ( -LRB- cord-265139-x7g3jcjm 119 19 NAFLD NAFLD NNP cord-265139-x7g3jcjm 119 20 ) ) -RRB- cord-265139-x7g3jcjm 119 21 , , , cord-265139-x7g3jcjm 119 22 a a DT cord-265139-x7g3jcjm 119 23 disorder disorder NN cord-265139-x7g3jcjm 119 24 that that WDT cord-265139-x7g3jcjm 119 25 is be VBZ cord-265139-x7g3jcjm 119 26 caused cause VBN cord-265139-x7g3jcjm 119 27 by by IN cord-265139-x7g3jcjm 119 28 a a DT cord-265139-x7g3jcjm 119 29 plethora plethora NN cord-265139-x7g3jcjm 119 30 of of IN cord-265139-x7g3jcjm 119 31 factors factor NNS cord-265139-x7g3jcjm 119 32 including include VBG cord-265139-x7g3jcjm 119 33 hepatic hepatic JJ cord-265139-x7g3jcjm 119 34 lipid lipid NN cord-265139-x7g3jcjm 119 35 accumulation accumulation NN cord-265139-x7g3jcjm 119 36 , , , cord-265139-x7g3jcjm 119 37 adipose adipose JJ cord-265139-x7g3jcjm 119 38 tissue tissue NN cord-265139-x7g3jcjm 119 39 and and CC cord-265139-x7g3jcjm 119 40 mitochondrial mitochondrial JJ cord-265139-x7g3jcjm 119 41 dysfunction dysfunction NN cord-265139-x7g3jcjm 119 42 , , , cord-265139-x7g3jcjm 119 43 a a DT cord-265139-x7g3jcjm 119 44 high high JJ cord-265139-x7g3jcjm 119 45 - - HYPH cord-265139-x7g3jcjm 119 46 fat fat NN cord-265139-x7g3jcjm 119 47 diet diet NN cord-265139-x7g3jcjm 119 48 , , , cord-265139-x7g3jcjm 119 49 obesity obesity NN cord-265139-x7g3jcjm 119 50 , , , cord-265139-x7g3jcjm 119 51 a a DT cord-265139-x7g3jcjm 119 52 chronic chronic JJ cord-265139-x7g3jcjm 119 53 inflammatory inflammatory JJ cord-265139-x7g3jcjm 119 54 state state NN cord-265139-x7g3jcjm 119 55 , , , cord-265139-x7g3jcjm 119 56 insulin insulin NN cord-265139-x7g3jcjm 119 57 resistance resistance NN cord-265139-x7g3jcjm 119 58 ( ( -LRB- cord-265139-x7g3jcjm 119 59 IR IR NNP cord-265139-x7g3jcjm 119 60 ) ) -RRB- cord-265139-x7g3jcjm 119 61 , , , cord-265139-x7g3jcjm 119 62 and and CC cord-265139-x7g3jcjm 119 63 genetic genetic JJ cord-265139-x7g3jcjm 119 64 and and CC cord-265139-x7g3jcjm 119 65 epigenetic epigenetic JJ cord-265139-x7g3jcjm 119 66 factors factor NNS cord-265139-x7g3jcjm 119 67 [ [ -LRB- cord-265139-x7g3jcjm 119 68 48 48 CD cord-265139-x7g3jcjm 119 69 , , , cord-265139-x7g3jcjm 119 70 55 55 CD cord-265139-x7g3jcjm 119 71 ] ] -RRB- cord-265139-x7g3jcjm 119 72 . . . cord-265139-x7g3jcjm 120 1 Finally finally RB cord-265139-x7g3jcjm 120 2 , , , cord-265139-x7g3jcjm 120 3 although although IN cord-265139-x7g3jcjm 120 4 more more JJR cord-265139-x7g3jcjm 120 5 functional functional JJ cord-265139-x7g3jcjm 120 6 circRNAs circrna NNS cord-265139-x7g3jcjm 120 7 are be VBP cord-265139-x7g3jcjm 120 8 being be VBG cord-265139-x7g3jcjm 120 9 gradually gradually RB cord-265139-x7g3jcjm 120 10 identified identify VBN cord-265139-x7g3jcjm 120 11 and and CC cord-265139-x7g3jcjm 120 12 some some DT cord-265139-x7g3jcjm 120 13 advances advance NNS cord-265139-x7g3jcjm 120 14 have have VBP cord-265139-x7g3jcjm 120 15 been be VBN cord-265139-x7g3jcjm 120 16 achieved achieve VBN cord-265139-x7g3jcjm 120 17 in in IN cord-265139-x7g3jcjm 120 18 atherosclerosis atherosclerosis NN cord-265139-x7g3jcjm 120 19 , , , cord-265139-x7g3jcjm 120 20 diabetes diabetes NN cord-265139-x7g3jcjm 120 21 , , , cord-265139-x7g3jcjm 120 22 hypertension hypertension NN cord-265139-x7g3jcjm 120 23 , , , cord-265139-x7g3jcjm 120 24 and and CC cord-265139-x7g3jcjm 120 25 CVD CVD NNP cord-265139-x7g3jcjm 120 26 , , , cord-265139-x7g3jcjm 120 27 the the DT cord-265139-x7g3jcjm 120 28 role role NN cord-265139-x7g3jcjm 120 29 of of IN cord-265139-x7g3jcjm 120 30 circRNAs circrna NNS cord-265139-x7g3jcjm 120 31 in in IN cord-265139-x7g3jcjm 120 32 connection connection NN cord-265139-x7g3jcjm 120 33 with with IN cord-265139-x7g3jcjm 120 34 dysregulated dysregulate VBN cord-265139-x7g3jcjm 120 35 adipogenesis adipogenesis NN cord-265139-x7g3jcjm 120 36 and and CC cord-265139-x7g3jcjm 120 37 obesity obesity NN cord-265139-x7g3jcjm 120 38 remains remain VBZ cord-265139-x7g3jcjm 120 39 largely largely RB cord-265139-x7g3jcjm 120 40 elusive elusive JJ cord-265139-x7g3jcjm 120 41 and and CC cord-265139-x7g3jcjm 120 42 needs need VBZ cord-265139-x7g3jcjm 120 43 to to TO cord-265139-x7g3jcjm 120 44 be be VB cord-265139-x7g3jcjm 120 45 explored explore VBN cord-265139-x7g3jcjm 120 46 further further RB cord-265139-x7g3jcjm 120 47 . . . cord-265139-x7g3jcjm 121 1 The the DT cord-265139-x7g3jcjm 121 2 next next JJ cord-265139-x7g3jcjm 121 3 section section NN cord-265139-x7g3jcjm 121 4 focuses focus VBZ cord-265139-x7g3jcjm 121 5 mainly mainly RB cord-265139-x7g3jcjm 121 6 on on IN cord-265139-x7g3jcjm 121 7 relevant relevant JJ cord-265139-x7g3jcjm 121 8 circRNA circrna NN cord-265139-x7g3jcjm 121 9 networks network NNS cord-265139-x7g3jcjm 121 10 implicated implicate VBN cord-265139-x7g3jcjm 121 11 in in IN cord-265139-x7g3jcjm 121 12 obesity obesity NN cord-265139-x7g3jcjm 121 13 from from IN cord-265139-x7g3jcjm 121 14 an an DT cord-265139-x7g3jcjm 121 15 epigenetic epigenetic JJ cord-265139-x7g3jcjm 121 16 perspective perspective NN cord-265139-x7g3jcjm 121 17 . . . cord-265139-x7g3jcjm 122 1 Obesity obesity NN cord-265139-x7g3jcjm 122 2 and and CC cord-265139-x7g3jcjm 122 3 its -PRON- PRP$ cord-265139-x7g3jcjm 122 4 metabolic metabolic JJ cord-265139-x7g3jcjm 122 5 consequences consequence NNS cord-265139-x7g3jcjm 122 6 have have VBP cord-265139-x7g3jcjm 122 7 been be VBN cord-265139-x7g3jcjm 122 8 considered consider VBN cord-265139-x7g3jcjm 122 9 as as IN cord-265139-x7g3jcjm 122 10 one one CD cord-265139-x7g3jcjm 122 11 of of IN cord-265139-x7g3jcjm 122 12 the the DT cord-265139-x7g3jcjm 122 13 most most RBS cord-265139-x7g3jcjm 122 14 threatening threatening JJ cord-265139-x7g3jcjm 122 15 health health NN cord-265139-x7g3jcjm 122 16 burdens burden NNS cord-265139-x7g3jcjm 122 17 of of IN cord-265139-x7g3jcjm 122 18 modern modern JJ cord-265139-x7g3jcjm 122 19 times time NNS cord-265139-x7g3jcjm 122 20 . . . cord-265139-x7g3jcjm 123 1 Multiple multiple JJ cord-265139-x7g3jcjm 123 2 investigations investigation NNS cord-265139-x7g3jcjm 123 3 have have VBP cord-265139-x7g3jcjm 123 4 brought bring VBN cord-265139-x7g3jcjm 123 5 forward forward RB cord-265139-x7g3jcjm 123 6 evidence evidence NN cord-265139-x7g3jcjm 123 7 that that IN cord-265139-x7g3jcjm 123 8 obesity obesity NN cord-265139-x7g3jcjm 123 9 is be VBZ cord-265139-x7g3jcjm 123 10 a a DT cord-265139-x7g3jcjm 123 11 complex complex JJ cord-265139-x7g3jcjm 123 12 condition condition NN cord-265139-x7g3jcjm 123 13 with with IN cord-265139-x7g3jcjm 123 14 multiple multiple JJ cord-265139-x7g3jcjm 123 15 etiologies etiology NNS cord-265139-x7g3jcjm 123 16 which which WDT cord-265139-x7g3jcjm 123 17 develop develop VBP cord-265139-x7g3jcjm 123 18 as as IN cord-265139-x7g3jcjm 123 19 a a DT cord-265139-x7g3jcjm 123 20 joint joint JJ cord-265139-x7g3jcjm 123 21 effect effect NN cord-265139-x7g3jcjm 123 22 of of IN cord-265139-x7g3jcjm 123 23 a a DT cord-265139-x7g3jcjm 123 24 variety variety NN cord-265139-x7g3jcjm 123 25 of of IN cord-265139-x7g3jcjm 123 26 factors factor NNS cord-265139-x7g3jcjm 123 27 such such JJ cord-265139-x7g3jcjm 123 28 as as IN cord-265139-x7g3jcjm 123 29 biological biological JJ cord-265139-x7g3jcjm 123 30 , , , cord-265139-x7g3jcjm 123 31 genetic genetic JJ cord-265139-x7g3jcjm 123 32 , , , cord-265139-x7g3jcjm 123 33 social social JJ cord-265139-x7g3jcjm 123 34 , , , cord-265139-x7g3jcjm 123 35 environmental environmental JJ cord-265139-x7g3jcjm 123 36 , , , cord-265139-x7g3jcjm 123 37 and and CC cord-265139-x7g3jcjm 123 38 behavioral behavioral JJ cord-265139-x7g3jcjm 123 39 determinants determinant NNS cord-265139-x7g3jcjm 123 40 [ [ -LRB- cord-265139-x7g3jcjm 123 41 56 56 CD cord-265139-x7g3jcjm 123 42 , , , cord-265139-x7g3jcjm 123 43 57 57 CD cord-265139-x7g3jcjm 123 44 ] ] -RRB- cord-265139-x7g3jcjm 123 45 . . . cord-265139-x7g3jcjm 124 1 The the DT cord-265139-x7g3jcjm 124 2 pathogenesis pathogenesis NN cord-265139-x7g3jcjm 124 3 of of IN cord-265139-x7g3jcjm 124 4 overweight overweight NN cord-265139-x7g3jcjm 124 5 and and CC cord-265139-x7g3jcjm 124 6 obesity obesity NN cord-265139-x7g3jcjm 124 7 has have VBZ cord-265139-x7g3jcjm 124 8 been be VBN cord-265139-x7g3jcjm 124 9 associated associate VBN cord-265139-x7g3jcjm 124 10 with with IN cord-265139-x7g3jcjm 124 11 altered altered JJ cord-265139-x7g3jcjm 124 12 adipose adipose JJ cord-265139-x7g3jcjm 124 13 tissue tissue NN cord-265139-x7g3jcjm 124 14 metabolism metabolism NN cord-265139-x7g3jcjm 124 15 and and CC cord-265139-x7g3jcjm 124 16 represents represent VBZ cord-265139-x7g3jcjm 124 17 an an DT cord-265139-x7g3jcjm 124 18 important important JJ cord-265139-x7g3jcjm 124 19 driving driving NN cord-265139-x7g3jcjm 124 20 factor factor NN cord-265139-x7g3jcjm 124 21 for for IN cord-265139-x7g3jcjm 124 22 many many JJ cord-265139-x7g3jcjm 124 23 human human JJ cord-265139-x7g3jcjm 124 24 metabolic metabolic JJ cord-265139-x7g3jcjm 124 25 disturbances disturbance NNS cord-265139-x7g3jcjm 124 26 and and CC cord-265139-x7g3jcjm 124 27 serious serious JJ cord-265139-x7g3jcjm 124 28 comorbidities comorbiditie NNS cord-265139-x7g3jcjm 124 29 including include VBG cord-265139-x7g3jcjm 124 30 T2DM T2DM NNP cord-265139-x7g3jcjm 124 31 , , , cord-265139-x7g3jcjm 124 32 CVD CVD NNP cord-265139-x7g3jcjm 124 33 , , , cord-265139-x7g3jcjm 124 34 and and CC cord-265139-x7g3jcjm 124 35 certain certain JJ cord-265139-x7g3jcjm 124 36 types type NNS cord-265139-x7g3jcjm 124 37 of of IN cord-265139-x7g3jcjm 124 38 cancer cancer NN cord-265139-x7g3jcjm 124 39 [ [ -LRB- cord-265139-x7g3jcjm 124 40 58 58 CD cord-265139-x7g3jcjm 124 41 , , , cord-265139-x7g3jcjm 124 42 59 59 CD cord-265139-x7g3jcjm 124 43 ] ] -RRB- cord-265139-x7g3jcjm 124 44 . . . cord-265139-x7g3jcjm 125 1 In in IN cord-265139-x7g3jcjm 125 2 addition addition NN cord-265139-x7g3jcjm 125 3 to to IN cord-265139-x7g3jcjm 125 4 its -PRON- PRP$ cord-265139-x7g3jcjm 125 5 association association NN cord-265139-x7g3jcjm 125 6 with with IN cord-265139-x7g3jcjm 125 7 chronic chronic JJ cord-265139-x7g3jcjm 125 8 diseases disease NNS cord-265139-x7g3jcjm 125 9 , , , cord-265139-x7g3jcjm 125 10 obesity obesity NN cord-265139-x7g3jcjm 125 11 is be VBZ cord-265139-x7g3jcjm 125 12 also also RB cord-265139-x7g3jcjm 125 13 thought think VBN cord-265139-x7g3jcjm 125 14 to to TO cord-265139-x7g3jcjm 125 15 increase increase VB cord-265139-x7g3jcjm 125 16 the the DT cord-265139-x7g3jcjm 125 17 risk risk NN cord-265139-x7g3jcjm 125 18 of of IN cord-265139-x7g3jcjm 125 19 developing develop VBG cord-265139-x7g3jcjm 125 20 severe severe JJ cord-265139-x7g3jcjm 125 21 forms form NNS cord-265139-x7g3jcjm 125 22 of of IN cord-265139-x7g3jcjm 125 23 respiratory respiratory JJ cord-265139-x7g3jcjm 125 24 failure failure NN cord-265139-x7g3jcjm 125 25 . . . cord-265139-x7g3jcjm 126 1 Indeed indeed RB cord-265139-x7g3jcjm 126 2 , , , cord-265139-x7g3jcjm 126 3 emerging emerge VBG cord-265139-x7g3jcjm 126 4 studies study NNS cord-265139-x7g3jcjm 126 5 revealed reveal VBD cord-265139-x7g3jcjm 126 6 a a DT cord-265139-x7g3jcjm 126 7 strong strong JJ cord-265139-x7g3jcjm 126 8 association association NN cord-265139-x7g3jcjm 126 9 between between IN cord-265139-x7g3jcjm 126 10 obesity obesity NN cord-265139-x7g3jcjm 126 11 and and CC cord-265139-x7g3jcjm 126 12 the the DT cord-265139-x7g3jcjm 126 13 ongoing ongoing JJ cord-265139-x7g3jcjm 126 14 pandemic pandemic NN cord-265139-x7g3jcjm 126 15 of of IN cord-265139-x7g3jcjm 126 16 coronavirus coronavirus NN cord-265139-x7g3jcjm 126 17 disease disease NN cord-265139-x7g3jcjm 126 18 ( ( -LRB- cord-265139-x7g3jcjm 126 19 COVID-19 COVID-19 NNP cord-265139-x7g3jcjm 126 20 ) ) -RRB- cord-265139-x7g3jcjm 126 21 , , , cord-265139-x7g3jcjm 126 22 which which WDT cord-265139-x7g3jcjm 126 23 is be VBZ cord-265139-x7g3jcjm 126 24 caused cause VBN cord-265139-x7g3jcjm 126 25 by by IN cord-265139-x7g3jcjm 126 26 infection infection NN cord-265139-x7g3jcjm 126 27 with with IN cord-265139-x7g3jcjm 126 28 severe severe JJ cord-265139-x7g3jcjm 126 29 acute acute JJ cord-265139-x7g3jcjm 126 30 respiratory respiratory JJ cord-265139-x7g3jcjm 126 31 syndrome syndrome NN cord-265139-x7g3jcjm 126 32 coronavirus coronavirus NN cord-265139-x7g3jcjm 126 33 2 2 CD cord-265139-x7g3jcjm 127 1 ( ( -LRB- cord-265139-x7g3jcjm 127 2 SARS SARS NNP cord-265139-x7g3jcjm 127 3 - - HYPH cord-265139-x7g3jcjm 127 4 CoV-2 CoV-2 NNP cord-265139-x7g3jcjm 127 5 ) ) -RRB- cord-265139-x7g3jcjm 128 1 [ [ -LRB- cord-265139-x7g3jcjm 128 2 60 60 CD cord-265139-x7g3jcjm 128 3 , , , cord-265139-x7g3jcjm 128 4 61 61 CD cord-265139-x7g3jcjm 128 5 ] ] -RRB- cord-265139-x7g3jcjm 128 6 . . . cord-265139-x7g3jcjm 129 1 Thus thus RB cord-265139-x7g3jcjm 129 2 , , , cord-265139-x7g3jcjm 129 3 the the DT cord-265139-x7g3jcjm 129 4 inexorable inexorable JJ cord-265139-x7g3jcjm 129 5 global global JJ cord-265139-x7g3jcjm 129 6 rise rise NN cord-265139-x7g3jcjm 129 7 of of IN cord-265139-x7g3jcjm 129 8 obesity obesity NN cord-265139-x7g3jcjm 129 9 will will MD cord-265139-x7g3jcjm 129 10 be be VB cord-265139-x7g3jcjm 129 11 the the DT cord-265139-x7g3jcjm 129 12 toughest tough JJS cord-265139-x7g3jcjm 129 13 challenge challenge NN cord-265139-x7g3jcjm 129 14 to to TO cord-265139-x7g3jcjm 129 15 face face VB cord-265139-x7g3jcjm 129 16 and and CC cord-265139-x7g3jcjm 129 17 demands demand NNS cord-265139-x7g3jcjm 129 18 novel novel JJ cord-265139-x7g3jcjm 129 19 and and CC cord-265139-x7g3jcjm 129 20 more more JJR cord-265139-x7g3jcjm 129 21 effective effective JJ cord-265139-x7g3jcjm 129 22 therapies therapy NNS cord-265139-x7g3jcjm 129 23 . . . cord-265139-x7g3jcjm 130 1 Evidence evidence NN cord-265139-x7g3jcjm 130 2 for for IN cord-265139-x7g3jcjm 130 3 a a DT cord-265139-x7g3jcjm 130 4 large large JJ cord-265139-x7g3jcjm 130 5 contribution contribution NN cord-265139-x7g3jcjm 130 6 of of IN cord-265139-x7g3jcjm 130 7 genetic genetic JJ cord-265139-x7g3jcjm 130 8 variation variation NN cord-265139-x7g3jcjm 130 9 to to IN cord-265139-x7g3jcjm 130 10 inter inter JJ cord-265139-x7g3jcjm 130 11 - - JJ cord-265139-x7g3jcjm 130 12 individual individual JJ cord-265139-x7g3jcjm 130 13 differences difference NNS cord-265139-x7g3jcjm 130 14 in in IN cord-265139-x7g3jcjm 130 15 body body NN cord-265139-x7g3jcjm 130 16 mass mass NN cord-265139-x7g3jcjm 130 17 index index NN cord-265139-x7g3jcjm 130 18 ( ( -LRB- cord-265139-x7g3jcjm 130 19 BMI BMI NNP cord-265139-x7g3jcjm 130 20 ) ) -RRB- cord-265139-x7g3jcjm 130 21 comes come VBZ cord-265139-x7g3jcjm 130 22 from from IN cord-265139-x7g3jcjm 130 23 twin twin JJ cord-265139-x7g3jcjm 130 24 , , , cord-265139-x7g3jcjm 130 25 human human JJ cord-265139-x7g3jcjm 130 26 linkage linkage NN cord-265139-x7g3jcjm 130 27 , , , cord-265139-x7g3jcjm 130 28 and and CC cord-265139-x7g3jcjm 130 29 association association NN cord-265139-x7g3jcjm 130 30 studies study NNS cord-265139-x7g3jcjm 130 31 of of IN cord-265139-x7g3jcjm 130 32 large large JJ cord-265139-x7g3jcjm 130 33 cohorts cohort NNS cord-265139-x7g3jcjm 130 34 . . . cord-265139-x7g3jcjm 131 1 Heritability heritability NN cord-265139-x7g3jcjm 131 2 estimates estimate NNS cord-265139-x7g3jcjm 131 3 for for IN cord-265139-x7g3jcjm 131 4 BMI bmi NN cord-265139-x7g3jcjm 131 5 range range NN cord-265139-x7g3jcjm 131 6 from from IN cord-265139-x7g3jcjm 131 7 31 31 CD cord-265139-x7g3jcjm 131 8 - - SYM cord-265139-x7g3jcjm 131 9 90 90 CD cord-265139-x7g3jcjm 131 10 % % NN cord-265139-x7g3jcjm 131 11 across across IN cord-265139-x7g3jcjm 131 12 different different JJ cord-265139-x7g3jcjm 131 13 family family NN cord-265139-x7g3jcjm 131 14 studies study NNS cord-265139-x7g3jcjm 131 15 [ [ -LRB- cord-265139-x7g3jcjm 131 16 62 62 CD cord-265139-x7g3jcjm 131 17 ] ] -RRB- cord-265139-x7g3jcjm 131 18 , , , cord-265139-x7g3jcjm 131 19 leaving leave VBG cord-265139-x7g3jcjm 131 20 the the DT cord-265139-x7g3jcjm 131 21 remaining remain VBG cord-265139-x7g3jcjm 131 22 variance variance NN cord-265139-x7g3jcjm 131 23 attributed attribute VBN cord-265139-x7g3jcjm 131 24 to to IN cord-265139-x7g3jcjm 131 25 environmental environmental JJ cord-265139-x7g3jcjm 131 26 factors factor NNS cord-265139-x7g3jcjm 131 27 . . . cord-265139-x7g3jcjm 132 1 However however RB cord-265139-x7g3jcjm 132 2 , , , cord-265139-x7g3jcjm 132 3 the the DT cord-265139-x7g3jcjm 132 4 genetic genetic JJ cord-265139-x7g3jcjm 132 5 variations variation NNS cord-265139-x7g3jcjm 132 6 , , , cord-265139-x7g3jcjm 132 7 measured measure VBN cord-265139-x7g3jcjm 132 8 through through IN cord-265139-x7g3jcjm 132 9 familial familial JJ cord-265139-x7g3jcjm 132 10 studies study NNS cord-265139-x7g3jcjm 132 11 , , , cord-265139-x7g3jcjm 132 12 affecting affect VBG cord-265139-x7g3jcjm 132 13 obesity obesity NN cord-265139-x7g3jcjm 132 14 and and CC cord-265139-x7g3jcjm 132 15 variations variation NNS cord-265139-x7g3jcjm 132 16 identified identify VBN cord-265139-x7g3jcjm 132 17 at at IN cord-265139-x7g3jcjm 132 18 different different JJ cord-265139-x7g3jcjm 132 19 loci locus NNS cord-265139-x7g3jcjm 132 20 , , , cord-265139-x7g3jcjm 132 21 together together RB cord-265139-x7g3jcjm 132 22 have have VBP cord-265139-x7g3jcjm 132 23 been be VBN cord-265139-x7g3jcjm 132 24 estimated estimate VBN cord-265139-x7g3jcjm 132 25 to to TO cord-265139-x7g3jcjm 132 26 explain explain VB cord-265139-x7g3jcjm 132 27 no no DT cord-265139-x7g3jcjm 132 28 more more JJR cord-265139-x7g3jcjm 132 29 than than IN cord-265139-x7g3jcjm 132 30 30 30 CD cord-265139-x7g3jcjm 132 31 % % NN cord-265139-x7g3jcjm 132 32 of of IN cord-265139-x7g3jcjm 132 33 the the DT cord-265139-x7g3jcjm 132 34 phenotypic phenotypic JJ cord-265139-x7g3jcjm 132 35 variation variation NN cord-265139-x7g3jcjm 132 36 [ [ -LRB- cord-265139-x7g3jcjm 132 37 63 63 CD cord-265139-x7g3jcjm 132 38 , , , cord-265139-x7g3jcjm 132 39 64 64 CD cord-265139-x7g3jcjm 132 40 ] ] -RRB- cord-265139-x7g3jcjm 132 41 . . . cord-265139-x7g3jcjm 133 1 Hence hence RB cord-265139-x7g3jcjm 133 2 , , , cord-265139-x7g3jcjm 133 3 the the DT cord-265139-x7g3jcjm 133 4 " " `` cord-265139-x7g3jcjm 133 5 missing miss VBG cord-265139-x7g3jcjm 133 6 heritability heritability NN cord-265139-x7g3jcjm 133 7 " " '' cord-265139-x7g3jcjm 133 8 could could MD cord-265139-x7g3jcjm 133 9 be be VB cord-265139-x7g3jcjm 133 10 attributed attribute VBN cord-265139-x7g3jcjm 133 11 to to IN cord-265139-x7g3jcjm 133 12 many many JJ cord-265139-x7g3jcjm 133 13 more more JJR cord-265139-x7g3jcjm 133 14 susceptibility susceptibility NN cord-265139-x7g3jcjm 133 15 factors factor NNS cord-265139-x7g3jcjm 133 16 that that WDT cord-265139-x7g3jcjm 133 17 remain remain VBP cord-265139-x7g3jcjm 133 18 to to TO cord-265139-x7g3jcjm 133 19 be be VB cord-265139-x7g3jcjm 133 20 uncovered uncover VBN cord-265139-x7g3jcjm 133 21 . . . cord-265139-x7g3jcjm 134 1 One one CD cord-265139-x7g3jcjm 134 2 of of IN cord-265139-x7g3jcjm 134 3 the the DT cord-265139-x7g3jcjm 134 4 suggested suggest VBN cord-265139-x7g3jcjm 134 5 mechanisms mechanism NNS cord-265139-x7g3jcjm 134 6 that that WDT cord-265139-x7g3jcjm 134 7 may may MD cord-265139-x7g3jcjm 134 8 account account VB cord-265139-x7g3jcjm 134 9 for for IN cord-265139-x7g3jcjm 134 10 the the DT cord-265139-x7g3jcjm 134 11 missing miss VBG cord-265139-x7g3jcjm 134 12 heritability heritability NN cord-265139-x7g3jcjm 134 13 is be VBZ cord-265139-x7g3jcjm 134 14 relative relative JJ cord-265139-x7g3jcjm 134 15 to to IN cord-265139-x7g3jcjm 134 16 epigenetic epigenetic JJ cord-265139-x7g3jcjm 134 17 programs program NNS cord-265139-x7g3jcjm 134 18 . . . cord-265139-x7g3jcjm 135 1 Epigenetics epigenetic NNS cord-265139-x7g3jcjm 135 2 can can MD cord-265139-x7g3jcjm 135 3 be be VB cord-265139-x7g3jcjm 135 4 defined define VBN cord-265139-x7g3jcjm 135 5 as as IN cord-265139-x7g3jcjm 135 6 acquired acquire VBN cord-265139-x7g3jcjm 135 7 changes change NNS cord-265139-x7g3jcjm 135 8 in in IN cord-265139-x7g3jcjm 135 9 chromatin chromatin NN cord-265139-x7g3jcjm 135 10 structure structure NN cord-265139-x7g3jcjm 135 11 through through IN cord-265139-x7g3jcjm 135 12 cell cell NN cord-265139-x7g3jcjm 135 13 division division NN cord-265139-x7g3jcjm 135 14 that that WDT cord-265139-x7g3jcjm 135 15 arise arise VBP cord-265139-x7g3jcjm 135 16 independently independently RB cord-265139-x7g3jcjm 135 17 of of IN cord-265139-x7g3jcjm 135 18 an an DT cord-265139-x7g3jcjm 135 19 alteration alteration NN cord-265139-x7g3jcjm 135 20 in in IN cord-265139-x7g3jcjm 135 21 genomic genomic JJ cord-265139-x7g3jcjm 135 22 DNA dna NN cord-265139-x7g3jcjm 135 23 sequences sequence NNS cord-265139-x7g3jcjm 135 24 [ [ -LRB- cord-265139-x7g3jcjm 135 25 65 65 CD cord-265139-x7g3jcjm 135 26 ] ] -RRB- cord-265139-x7g3jcjm 135 27 . . . cord-265139-x7g3jcjm 136 1 Epigenetic epigenetic JJ cord-265139-x7g3jcjm 136 2 changes change NNS cord-265139-x7g3jcjm 136 3 are be VBP cord-265139-x7g3jcjm 136 4 dynamic dynamic JJ cord-265139-x7g3jcjm 136 5 and and CC cord-265139-x7g3jcjm 136 6 potentially potentially RB cord-265139-x7g3jcjm 136 7 reversible reversible JJ cord-265139-x7g3jcjm 136 8 marks mark NNS cord-265139-x7g3jcjm 136 9 affecting affect VBG cord-265139-x7g3jcjm 136 10 gene gene NN cord-265139-x7g3jcjm 136 11 regulation regulation NN cord-265139-x7g3jcjm 136 12 . . . cord-265139-x7g3jcjm 137 1 They -PRON- PRP cord-265139-x7g3jcjm 137 2 can can MD cord-265139-x7g3jcjm 137 3 include include VB cord-265139-x7g3jcjm 137 4 three three CD cord-265139-x7g3jcjm 137 5 main main JJ cord-265139-x7g3jcjm 137 6 categories category NNS cord-265139-x7g3jcjm 137 7 : : : cord-265139-x7g3jcjm 137 8 DNA dna NN cord-265139-x7g3jcjm 137 9 methylation methylation NN cord-265139-x7g3jcjm 137 10 , , , cord-265139-x7g3jcjm 137 11 histone histone NN cord-265139-x7g3jcjm 137 12 modifications modification NNS cord-265139-x7g3jcjm 137 13 , , , cord-265139-x7g3jcjm 137 14 and and CC cord-265139-x7g3jcjm 137 15 ncRNAs ncRNAs NNP cord-265139-x7g3jcjm 137 16 [ [ -LRB- cord-265139-x7g3jcjm 137 17 66 66 CD cord-265139-x7g3jcjm 137 18 ] ] -RRB- cord-265139-x7g3jcjm 137 19 . . . cord-265139-x7g3jcjm 138 1 Ongoing ongoing JJ cord-265139-x7g3jcjm 138 2 research research NN cord-265139-x7g3jcjm 138 3 is be VBZ cord-265139-x7g3jcjm 138 4 revealing reveal VBG cord-265139-x7g3jcjm 138 5 the the DT cord-265139-x7g3jcjm 138 6 extent extent NN cord-265139-x7g3jcjm 138 7 of of IN cord-265139-x7g3jcjm 138 8 the the DT cord-265139-x7g3jcjm 138 9 influence influence NN cord-265139-x7g3jcjm 138 10 of of IN cord-265139-x7g3jcjm 138 11 epigenetics epigenetic NNS cord-265139-x7g3jcjm 138 12 in in IN cord-265139-x7g3jcjm 138 13 many many JJ cord-265139-x7g3jcjm 138 14 diseases disease NNS cord-265139-x7g3jcjm 138 15 . . . cord-265139-x7g3jcjm 139 1 In in IN cord-265139-x7g3jcjm 139 2 support support NN cord-265139-x7g3jcjm 139 3 of of IN cord-265139-x7g3jcjm 139 4 this this DT cord-265139-x7g3jcjm 139 5 claim claim NN cord-265139-x7g3jcjm 139 6 , , , cord-265139-x7g3jcjm 139 7 epigenetic epigenetic JJ cord-265139-x7g3jcjm 139 8 differences difference NNS cord-265139-x7g3jcjm 139 9 between between IN cord-265139-x7g3jcjm 139 10 individuals individual NNS cord-265139-x7g3jcjm 139 11 have have VBP cord-265139-x7g3jcjm 139 12 been be VBN cord-265139-x7g3jcjm 139 13 found find VBN cord-265139-x7g3jcjm 139 14 to to TO cord-265139-x7g3jcjm 139 15 contribute contribute VB cord-265139-x7g3jcjm 139 16 to to IN cord-265139-x7g3jcjm 139 17 the the DT cord-265139-x7g3jcjm 139 18 explanation explanation NN cord-265139-x7g3jcjm 139 19 of of IN cord-265139-x7g3jcjm 139 20 the the DT cord-265139-x7g3jcjm 139 21 monozygotic monozygotic JJ cord-265139-x7g3jcjm 139 22 twin twin JJ cord-265139-x7g3jcjm 139 23 discordance discordance NN cord-265139-x7g3jcjm 139 24 rates rate NNS cord-265139-x7g3jcjm 139 25 for for IN cord-265139-x7g3jcjm 139 26 common common JJ cord-265139-x7g3jcjm 139 27 phenotypes phenotype NNS cord-265139-x7g3jcjm 139 28 [ [ -LRB- cord-265139-x7g3jcjm 139 29 67 67 CD cord-265139-x7g3jcjm 139 30 ] ] -RRB- cord-265139-x7g3jcjm 139 31 . . . cord-265139-x7g3jcjm 140 1 While while IN cord-265139-x7g3jcjm 140 2 DNA dna NN cord-265139-x7g3jcjm 140 3 methylation methylation NN cord-265139-x7g3jcjm 140 4 and and CC cord-265139-x7g3jcjm 140 5 histone histone NN cord-265139-x7g3jcjm 140 6 modifications modification NNS cord-265139-x7g3jcjm 140 7 occur occur VBP cord-265139-x7g3jcjm 140 8 at at IN cord-265139-x7g3jcjm 140 9 the the DT cord-265139-x7g3jcjm 140 10 level level NN cord-265139-x7g3jcjm 140 11 of of IN cord-265139-x7g3jcjm 140 12 chromatin chromatin NN cord-265139-x7g3jcjm 140 13 and and CC cord-265139-x7g3jcjm 140 14 are be VBP cord-265139-x7g3jcjm 140 15 well well RB cord-265139-x7g3jcjm 140 16 - - HYPH cord-265139-x7g3jcjm 140 17 recognized recognize VBN cord-265139-x7g3jcjm 140 18 as as IN cord-265139-x7g3jcjm 140 19 drivers driver NNS cord-265139-x7g3jcjm 140 20 for for IN cord-265139-x7g3jcjm 140 21 the the DT cord-265139-x7g3jcjm 140 22 disease disease NN cord-265139-x7g3jcjm 140 23 phenotype phenotype NN cord-265139-x7g3jcjm 140 24 , , , cord-265139-x7g3jcjm 140 25 ncRNAs ncRNAs NNP cord-265139-x7g3jcjm 140 26 represent represent VBP cord-265139-x7g3jcjm 140 27 a a DT cord-265139-x7g3jcjm 140 28 relatively relatively RB cord-265139-x7g3jcjm 140 29 new new JJ cord-265139-x7g3jcjm 140 30 concept concept NN cord-265139-x7g3jcjm 140 31 in in IN cord-265139-x7g3jcjm 140 32 epigenetics epigenetic NNS cord-265139-x7g3jcjm 140 33 and and CC cord-265139-x7g3jcjm 140 34 act act VBP cord-265139-x7g3jcjm 140 35 mainly mainly RB cord-265139-x7g3jcjm 140 36 at at IN cord-265139-x7g3jcjm 140 37 the the DT cord-265139-x7g3jcjm 140 38 transcriptional transcriptional JJ cord-265139-x7g3jcjm 140 39 and and CC cord-265139-x7g3jcjm 140 40 posttranslational posttranslational JJ cord-265139-x7g3jcjm 140 41 levels level NNS cord-265139-x7g3jcjm 140 42 . . . cord-265139-x7g3jcjm 141 1 Concerning concern VBG cord-265139-x7g3jcjm 141 2 obesity obesity NN cord-265139-x7g3jcjm 141 3 , , , cord-265139-x7g3jcjm 141 4 studies study NNS cord-265139-x7g3jcjm 141 5 have have VBP cord-265139-x7g3jcjm 141 6 reported report VBN cord-265139-x7g3jcjm 141 7 that that IN cord-265139-x7g3jcjm 141 8 epigenetic epigenetic JJ cord-265139-x7g3jcjm 141 9 change change NN cord-265139-x7g3jcjm 141 10 plays play VBZ cord-265139-x7g3jcjm 141 11 a a DT cord-265139-x7g3jcjm 141 12 key key JJ cord-265139-x7g3jcjm 141 13 role role NN cord-265139-x7g3jcjm 141 14 in in IN cord-265139-x7g3jcjm 141 15 the the DT cord-265139-x7g3jcjm 141 16 occurrence occurrence NN cord-265139-x7g3jcjm 141 17 and and CC cord-265139-x7g3jcjm 141 18 development development NN cord-265139-x7g3jcjm 141 19 of of IN cord-265139-x7g3jcjm 141 20 this this DT cord-265139-x7g3jcjm 141 21 medical medical JJ cord-265139-x7g3jcjm 141 22 condition condition NN cord-265139-x7g3jcjm 141 23 [ [ -LRB- cord-265139-x7g3jcjm 141 24 68 68 CD cord-265139-x7g3jcjm 141 25 ] ] -RRB- cord-265139-x7g3jcjm 141 26 . . . cord-265139-x7g3jcjm 142 1 In in IN cord-265139-x7g3jcjm 142 2 addition addition NN cord-265139-x7g3jcjm 142 3 to to IN cord-265139-x7g3jcjm 142 4 classical classical JJ cord-265139-x7g3jcjm 142 5 epigenetic epigenetic JJ cord-265139-x7g3jcjm 142 6 modifications modification NNS cord-265139-x7g3jcjm 142 7 , , , cord-265139-x7g3jcjm 142 8 a a DT cord-265139-x7g3jcjm 142 9 variety variety NN cord-265139-x7g3jcjm 142 10 of of IN cord-265139-x7g3jcjm 142 11 ncRNAs ncrna NNS cord-265139-x7g3jcjm 142 12 have have VBP cord-265139-x7g3jcjm 142 13 been be VBN cord-265139-x7g3jcjm 142 14 uncovered uncover VBN cord-265139-x7g3jcjm 142 15 in in IN cord-265139-x7g3jcjm 142 16 different different JJ cord-265139-x7g3jcjm 142 17 cells cell NNS cord-265139-x7g3jcjm 142 18 and and CC cord-265139-x7g3jcjm 142 19 organs organ NNS cord-265139-x7g3jcjm 142 20 including include VBG cord-265139-x7g3jcjm 142 21 adipose adipose JJ cord-265139-x7g3jcjm 142 22 tissues tissue NNS cord-265139-x7g3jcjm 142 23 , , , cord-265139-x7g3jcjm 142 24 many many JJ cord-265139-x7g3jcjm 142 25 of of IN cord-265139-x7g3jcjm 142 26 which which WDT cord-265139-x7g3jcjm 142 27 are be VBP cord-265139-x7g3jcjm 142 28 involved involve VBN cord-265139-x7g3jcjm 142 29 in in IN cord-265139-x7g3jcjm 142 30 the the DT cord-265139-x7g3jcjm 142 31 regulation regulation NN cord-265139-x7g3jcjm 142 32 of of IN cord-265139-x7g3jcjm 142 33 adipogenesis adipogenesis NN cord-265139-x7g3jcjm 142 34 and and CC cord-265139-x7g3jcjm 142 35 other other JJ cord-265139-x7g3jcjm 142 36 metabolic metabolic JJ cord-265139-x7g3jcjm 142 37 processes process NNS cord-265139-x7g3jcjm 142 38 implying imply VBG cord-265139-x7g3jcjm 142 39 their -PRON- PRP$ cord-265139-x7g3jcjm 142 40 role role NN cord-265139-x7g3jcjm 142 41 in in IN cord-265139-x7g3jcjm 142 42 the the DT cord-265139-x7g3jcjm 142 43 etiology etiology NN cord-265139-x7g3jcjm 142 44 of of IN cord-265139-x7g3jcjm 142 45 obesity obesity NN cord-265139-x7g3jcjm 142 46 [ [ -LRB- cord-265139-x7g3jcjm 142 47 69 69 CD cord-265139-x7g3jcjm 142 48 ] ] -RRB- cord-265139-x7g3jcjm 142 49 . . . cord-265139-x7g3jcjm 143 1 While while IN cord-265139-x7g3jcjm 143 2 lncRNAs lncRNAs NNP cord-265139-x7g3jcjm 143 3 and and CC cord-265139-x7g3jcjm 143 4 miRNAs miRNAs NNP cord-265139-x7g3jcjm 143 5 are be VBP cord-265139-x7g3jcjm 143 6 extensively extensively RB cord-265139-x7g3jcjm 143 7 investigated investigate VBN cord-265139-x7g3jcjm 143 8 in in IN cord-265139-x7g3jcjm 143 9 obesity obesity NN cord-265139-x7g3jcjm 143 10 biology biology NN cord-265139-x7g3jcjm 143 11 [ [ -LRB- cord-265139-x7g3jcjm 143 12 69 69 CD cord-265139-x7g3jcjm 143 13 ] ] -RRB- cord-265139-x7g3jcjm 143 14 [ [ -LRB- cord-265139-x7g3jcjm 143 15 70 70 CD cord-265139-x7g3jcjm 143 16 ] ] -RRB- cord-265139-x7g3jcjm 143 17 [ [ -LRB- cord-265139-x7g3jcjm 143 18 71 71 CD cord-265139-x7g3jcjm 143 19 ] ] -RRB- cord-265139-x7g3jcjm 143 20 , , , cord-265139-x7g3jcjm 143 21 studies study NNS cord-265139-x7g3jcjm 143 22 of of IN cord-265139-x7g3jcjm 143 23 circRNAs circrna NNS cord-265139-x7g3jcjm 143 24 in in IN cord-265139-x7g3jcjm 143 25 this this DT cord-265139-x7g3jcjm 143 26 respect respect NN cord-265139-x7g3jcjm 143 27 have have VBP cord-265139-x7g3jcjm 143 28 just just RB cord-265139-x7g3jcjm 143 29 begun begin VBN cord-265139-x7g3jcjm 143 30 . . . cord-265139-x7g3jcjm 144 1 Despite despite IN cord-265139-x7g3jcjm 144 2 the the DT cord-265139-x7g3jcjm 144 3 established establish VBN cord-265139-x7g3jcjm 144 4 link link NN cord-265139-x7g3jcjm 144 5 between between IN cord-265139-x7g3jcjm 144 6 circRNAs circrna NNS cord-265139-x7g3jcjm 144 7 and and CC cord-265139-x7g3jcjm 144 8 several several JJ cord-265139-x7g3jcjm 144 9 metabolic metabolic JJ cord-265139-x7g3jcjm 144 10 diseases disease NNS cord-265139-x7g3jcjm 144 11 , , , cord-265139-x7g3jcjm 144 12 investigations investigation NNS cord-265139-x7g3jcjm 144 13 on on IN cord-265139-x7g3jcjm 144 14 the the DT cord-265139-x7g3jcjm 144 15 potential potential JJ cord-265139-x7g3jcjm 144 16 connection connection NN cord-265139-x7g3jcjm 144 17 between between IN cord-265139-x7g3jcjm 144 18 circRNAs circrna NNS cord-265139-x7g3jcjm 144 19 and and CC cord-265139-x7g3jcjm 144 20 adipogenesis adipogenesis NN cord-265139-x7g3jcjm 144 21 remain remain VBP cord-265139-x7g3jcjm 144 22 rare rare JJ cord-265139-x7g3jcjm 144 23 . . . cord-265139-x7g3jcjm 145 1 Currently currently RB cord-265139-x7g3jcjm 145 2 , , , cord-265139-x7g3jcjm 145 3 there there EX cord-265139-x7g3jcjm 145 4 are be VBP cord-265139-x7g3jcjm 145 5 few few JJ cord-265139-x7g3jcjm 145 6 emerging emerge VBG cord-265139-x7g3jcjm 145 7 studies study NNS cord-265139-x7g3jcjm 145 8 extending extend VBG cord-265139-x7g3jcjm 145 9 the the DT cord-265139-x7g3jcjm 145 10 scope scope NN cord-265139-x7g3jcjm 145 11 of of IN cord-265139-x7g3jcjm 145 12 the the DT cord-265139-x7g3jcjm 145 13 disease disease NN cord-265139-x7g3jcjm 145 14 - - HYPH cord-265139-x7g3jcjm 145 15 relevant relevant JJ cord-265139-x7g3jcjm 145 16 role role NN cord-265139-x7g3jcjm 145 17 of of IN cord-265139-x7g3jcjm 145 18 circRNAs circrna NNS cord-265139-x7g3jcjm 145 19 to to IN cord-265139-x7g3jcjm 145 20 obesity obesity NN cord-265139-x7g3jcjm 145 21 and and CC cord-265139-x7g3jcjm 145 22 underlying underlying NN cord-265139-x7g3jcjm 145 23 mechanisms mechanism NNS cord-265139-x7g3jcjm 145 24 . . . cord-265139-x7g3jcjm 146 1 Hence hence RB cord-265139-x7g3jcjm 146 2 , , , cord-265139-x7g3jcjm 146 3 a a DT cord-265139-x7g3jcjm 146 4 review review NN cord-265139-x7g3jcjm 146 5 of of IN cord-265139-x7g3jcjm 146 6 examples example NNS cord-265139-x7g3jcjm 146 7 in in IN cord-265139-x7g3jcjm 146 8 the the DT cord-265139-x7g3jcjm 146 9 literature literature NN cord-265139-x7g3jcjm 146 10 , , , cord-265139-x7g3jcjm 146 11 suggesting suggest VBG cord-265139-x7g3jcjm 146 12 key key JJ cord-265139-x7g3jcjm 146 13 regulatory regulatory JJ cord-265139-x7g3jcjm 146 14 roles role NNS cord-265139-x7g3jcjm 146 15 of of IN cord-265139-x7g3jcjm 146 16 circRNAs circrna NNS cord-265139-x7g3jcjm 146 17 in in IN cord-265139-x7g3jcjm 146 18 many many JJ cord-265139-x7g3jcjm 146 19 biological biological JJ cord-265139-x7g3jcjm 146 20 processes process NNS cord-265139-x7g3jcjm 146 21 associated associate VBN cord-265139-x7g3jcjm 146 22 with with IN cord-265139-x7g3jcjm 146 23 obesity obesity NN cord-265139-x7g3jcjm 146 24 , , , cord-265139-x7g3jcjm 146 25 including include VBG cord-265139-x7g3jcjm 146 26 adipogenesis adipogenesis NN cord-265139-x7g3jcjm 146 27 and and CC cord-265139-x7g3jcjm 146 28 adipocyte adipocyte NN cord-265139-x7g3jcjm 146 29 differentiation differentiation NN cord-265139-x7g3jcjm 146 30 , , , cord-265139-x7g3jcjm 146 31 is be VBZ cord-265139-x7g3jcjm 146 32 discussed discuss VBN cord-265139-x7g3jcjm 146 33 next next RB cord-265139-x7g3jcjm 146 34 . . . cord-265139-x7g3jcjm 147 1 Animal animal JJ cord-265139-x7g3jcjm 147 2 adipose adipose JJ cord-265139-x7g3jcjm 147 3 tissue tissue NN cord-265139-x7g3jcjm 147 4 . . . cord-265139-x7g3jcjm 148 1 Emerging emerge VBG cord-265139-x7g3jcjm 148 2 evidence evidence NN cord-265139-x7g3jcjm 148 3 from from IN cord-265139-x7g3jcjm 148 4 in in IN cord-265139-x7g3jcjm 148 5 vitro vitro FW cord-265139-x7g3jcjm 148 6 and and CC cord-265139-x7g3jcjm 148 7 in in IN cord-265139-x7g3jcjm 148 8 vivo vivo NNP cord-265139-x7g3jcjm 148 9 animal animal NN cord-265139-x7g3jcjm 148 10 studies study NNS cord-265139-x7g3jcjm 148 11 suggest suggest VBP cord-265139-x7g3jcjm 148 12 that that IN cord-265139-x7g3jcjm 148 13 circRNAs circrna NNS cord-265139-x7g3jcjm 148 14 are be VBP cord-265139-x7g3jcjm 148 15 expressed express VBN cord-265139-x7g3jcjm 148 16 in in IN cord-265139-x7g3jcjm 148 17 adipose adipose JJ cord-265139-x7g3jcjm 148 18 tissues tissue NNS cord-265139-x7g3jcjm 148 19 and and CC cord-265139-x7g3jcjm 148 20 may may MD cord-265139-x7g3jcjm 148 21 modulate modulate VB cord-265139-x7g3jcjm 148 22 adipogenesis adipogenesis NN cord-265139-x7g3jcjm 148 23 and and CC cord-265139-x7g3jcjm 148 24 lipid lipid NN cord-265139-x7g3jcjm 148 25 metabolism metabolism NN cord-265139-x7g3jcjm 148 26 . . . cord-265139-x7g3jcjm 149 1 In in IN cord-265139-x7g3jcjm 149 2 this this DT cord-265139-x7g3jcjm 149 3 respect respect NN cord-265139-x7g3jcjm 149 4 , , , cord-265139-x7g3jcjm 149 5 Li Li NNP cord-265139-x7g3jcjm 149 6 and and CC cord-265139-x7g3jcjm 149 7 colleagues colleague NNS cord-265139-x7g3jcjm 149 8 identified identify VBD cord-265139-x7g3jcjm 149 9 several several JJ cord-265139-x7g3jcjm 149 10 circRNAs circrna NNS cord-265139-x7g3jcjm 149 11 differentially differentially RB cord-265139-x7g3jcjm 149 12 expressed express VBN cord-265139-x7g3jcjm 149 13 in in IN cord-265139-x7g3jcjm 149 14 the the DT cord-265139-x7g3jcjm 149 15 subcutaneous subcutaneous JJ cord-265139-x7g3jcjm 149 16 adipose adipose JJ cord-265139-x7g3jcjm 149 17 tissue tissue NN cord-265139-x7g3jcjm 149 18 of of IN cord-265139-x7g3jcjm 149 19 Large large JJ cord-265139-x7g3jcjm 149 20 White white JJ cord-265139-x7g3jcjm 149 21 pigs pig NNS cord-265139-x7g3jcjm 149 22 and and CC cord-265139-x7g3jcjm 149 23 Laiwu Laiwu NNP cord-265139-x7g3jcjm 149 24 pigs pig NNS cord-265139-x7g3jcjm 149 25 [ [ -LRB- cord-265139-x7g3jcjm 149 26 72 72 CD cord-265139-x7g3jcjm 149 27 ] ] -RRB- cord-265139-x7g3jcjm 149 28 . . . cord-265139-x7g3jcjm 150 1 A a DT cord-265139-x7g3jcjm 150 2 further further JJ cord-265139-x7g3jcjm 150 3 analysis analysis NN cord-265139-x7g3jcjm 150 4 revealed reveal VBD cord-265139-x7g3jcjm 150 5 that that IN cord-265139-x7g3jcjm 150 6 circRNA_11897 circRNA_11897 NNP cord-265139-x7g3jcjm 150 7 was be VBD cord-265139-x7g3jcjm 150 8 the the DT cord-265139-x7g3jcjm 150 9 most most RBS cord-265139-x7g3jcjm 150 10 significantly significantly RB cord-265139-x7g3jcjm 150 11 downregulated downregulate VBN cord-265139-x7g3jcjm 150 12 , , , cord-265139-x7g3jcjm 150 13 whereas whereas IN cord-265139-x7g3jcjm 150 14 circRNA_26852 circRNA_26852 NNP cord-265139-x7g3jcjm 150 15 was be VBD cord-265139-x7g3jcjm 150 16 the the DT cord-265139-x7g3jcjm 150 17 most most RBS cord-265139-x7g3jcjm 150 18 significantly significantly RB cord-265139-x7g3jcjm 150 19 upregulated upregulate VBN cord-265139-x7g3jcjm 150 20 ; ; : cord-265139-x7g3jcjm 150 21 both both DT cord-265139-x7g3jcjm 150 22 circRNAs circrna NNS cord-265139-x7g3jcjm 150 23 were be VBD cord-265139-x7g3jcjm 150 24 significantly significantly RB cord-265139-x7g3jcjm 150 25 involved involve VBN cord-265139-x7g3jcjm 150 26 in in IN cord-265139-x7g3jcjm 150 27 pathways pathway NNS cord-265139-x7g3jcjm 150 28 associated associate VBN cord-265139-x7g3jcjm 150 29 with with IN cord-265139-x7g3jcjm 150 30 adipocyte adipocyte JJ cord-265139-x7g3jcjm 150 31 differentiation differentiation NN cord-265139-x7g3jcjm 150 32 and and CC cord-265139-x7g3jcjm 150 33 lipid lipid NN cord-265139-x7g3jcjm 150 34 metabolism metabolism NN cord-265139-x7g3jcjm 150 35 [ [ -LRB- cord-265139-x7g3jcjm 150 36 72 72 CD cord-265139-x7g3jcjm 150 37 ] ] -RRB- cord-265139-x7g3jcjm 150 38 ( ( -LRB- cord-265139-x7g3jcjm 150 39 Table table NN cord-265139-x7g3jcjm 150 40 1 1 CD cord-265139-x7g3jcjm 150 41 ) ) -RRB- cord-265139-x7g3jcjm 150 42 . . . cord-265139-x7g3jcjm 151 1 In in IN cord-265139-x7g3jcjm 151 2 another another DT cord-265139-x7g3jcjm 151 3 study study NN cord-265139-x7g3jcjm 151 4 , , , cord-265139-x7g3jcjm 151 5 Liu Liu NNP cord-265139-x7g3jcjm 151 6 X X NNP cord-265139-x7g3jcjm 151 7 et et NNP cord-265139-x7g3jcjm 151 8 al al NNP cord-265139-x7g3jcjm 151 9 . . NNP cord-265139-x7g3jcjm 151 10 identified identify VBD cord-265139-x7g3jcjm 151 11 850 850 CD cord-265139-x7g3jcjm 151 12 circRNAs circrna NNS cord-265139-x7g3jcjm 151 13 differentially differentially RB cord-265139-x7g3jcjm 151 14 expressed express VBN cord-265139-x7g3jcjm 151 15 during during IN cord-265139-x7g3jcjm 151 16 subcutaneous subcutaneous JJ cord-265139-x7g3jcjm 151 17 adipogenesis adipogenesis NN cord-265139-x7g3jcjm 151 18 in in IN cord-265139-x7g3jcjm 151 19 Chinese chinese JJ cord-265139-x7g3jcjm 151 20 Erhualian erhualian JJ cord-265139-x7g3jcjm 151 21 pigs pig NNS cord-265139-x7g3jcjm 151 22 . . . cord-265139-x7g3jcjm 152 1 These these DT cord-265139-x7g3jcjm 152 2 transcripts transcript NNS cord-265139-x7g3jcjm 152 3 were be VBD cord-265139-x7g3jcjm 152 4 shown show VBN cord-265139-x7g3jcjm 152 5 to to TO cord-265139-x7g3jcjm 152 6 be be VB cord-265139-x7g3jcjm 152 7 implicated implicate VBN cord-265139-x7g3jcjm 152 8 in in IN cord-265139-x7g3jcjm 152 9 multiple multiple JJ cord-265139-x7g3jcjm 152 10 biological biological JJ cord-265139-x7g3jcjm 152 11 processes process NNS cord-265139-x7g3jcjm 152 12 including include VBG cord-265139-x7g3jcjm 152 13 lipid lipid NN cord-265139-x7g3jcjm 152 14 metabolic metabolic NN cord-265139-x7g3jcjm 152 15 and and CC cord-265139-x7g3jcjm 152 16 cell cell NN cord-265139-x7g3jcjm 152 17 differentiation differentiation NN cord-265139-x7g3jcjm 152 18 processes process NNS cord-265139-x7g3jcjm 152 19 [ [ -LRB- cord-265139-x7g3jcjm 152 20 73 73 CD cord-265139-x7g3jcjm 152 21 ] ] -RRB- cord-265139-x7g3jcjm 152 22 . . . cord-265139-x7g3jcjm 153 1 More more RBR cord-265139-x7g3jcjm 153 2 recently recently RB cord-265139-x7g3jcjm 153 3 , , , cord-265139-x7g3jcjm 153 4 an an DT cord-265139-x7g3jcjm 153 5 interesting interesting JJ cord-265139-x7g3jcjm 153 6 study study NN cord-265139-x7g3jcjm 153 7 indicated indicate VBD cord-265139-x7g3jcjm 153 8 that that IN cord-265139-x7g3jcjm 153 9 circSAMD4A circSAMD4A , cord-265139-x7g3jcjm 153 10 ( ( -LRB- cord-265139-x7g3jcjm 153 11 sterile sterile JJ cord-265139-x7g3jcjm 153 12 alpha alpha NN cord-265139-x7g3jcjm 153 13 motif motif NN cord-265139-x7g3jcjm 153 14 domain domain NN cord-265139-x7g3jcjm 153 15 containing contain VBG cord-265139-x7g3jcjm 153 16 4A 4a CD cord-265139-x7g3jcjm 153 17 ; ; : cord-265139-x7g3jcjm 153 18 also also RB cord-265139-x7g3jcjm 153 19 named name VBN cord-265139-x7g3jcjm 153 20 hsa_circ_0004846 hsa_circ_0004846 NNP cord-265139-x7g3jcjm 153 21 ) ) -RRB- cord-265139-x7g3jcjm 153 22 controls control VBZ cord-265139-x7g3jcjm 153 23 adipogenesis adipogenesis NN cord-265139-x7g3jcjm 153 24 in in IN cord-265139-x7g3jcjm 153 25 obesity obesity NN cord-265139-x7g3jcjm 153 26 by by IN cord-265139-x7g3jcjm 153 27 binding bind VBG cord-265139-x7g3jcjm 153 28 to to IN cord-265139-x7g3jcjm 153 29 miR-138 mir-138 JJ cord-265139-x7g3jcjm 153 30 - - HYPH cord-265139-x7g3jcjm 153 31 5p 5p CD cord-265139-x7g3jcjm 153 32 [ [ -LRB- cord-265139-x7g3jcjm 153 33 74 74 CD cord-265139-x7g3jcjm 153 34 ] ] -RRB- cord-265139-x7g3jcjm 153 35 . . . cord-265139-x7g3jcjm 154 1 In in IN cord-265139-x7g3jcjm 154 2 high high JJ cord-265139-x7g3jcjm 154 3 - - HYPH cord-265139-x7g3jcjm 154 4 fat fat NN cord-265139-x7g3jcjm 154 5 diet diet NN cord-265139-x7g3jcjm 154 6 ( ( -LRB- cord-265139-x7g3jcjm 154 7 HFD)-induced hfd)-induce VBN cord-265139-x7g3jcjm 154 8 obese obese JJ cord-265139-x7g3jcjm 154 9 mice mouse NNS cord-265139-x7g3jcjm 154 10 , , , cord-265139-x7g3jcjm 154 11 mmu_circ_0000529 mmu_circ_0000529 XX cord-265139-x7g3jcjm 154 12 ( ( -LRB- cord-265139-x7g3jcjm 154 13 the the DT cord-265139-x7g3jcjm 154 14 homologous homologous JJ cord-265139-x7g3jcjm 154 15 mouse mouse NN cord-265139-x7g3jcjm 154 16 circRNA circrna NN cord-265139-x7g3jcjm 154 17 for for IN cord-265139-x7g3jcjm 154 18 circSAMD4A circSAMD4A NNP cord-265139-x7g3jcjm 154 19 ) ) -RRB- cord-265139-x7g3jcjm 154 20 knockdown knockdown NN cord-265139-x7g3jcjm 154 21 reversed reverse VBD cord-265139-x7g3jcjm 154 22 the the DT cord-265139-x7g3jcjm 154 23 associated associated JJ cord-265139-x7g3jcjm 154 24 weight weight NN cord-265139-x7g3jcjm 154 25 gain gain NN cord-265139-x7g3jcjm 154 26 , , , cord-265139-x7g3jcjm 154 27 reduced reduce VBN cord-265139-x7g3jcjm 154 28 food food NN cord-265139-x7g3jcjm 154 29 intake intake NN cord-265139-x7g3jcjm 154 30 , , , cord-265139-x7g3jcjm 154 31 lowered lower VBD cord-265139-x7g3jcjm 154 32 body body NN cord-265139-x7g3jcjm 154 33 fat fat NN cord-265139-x7g3jcjm 154 34 , , , cord-265139-x7g3jcjm 154 35 and and CC cord-265139-x7g3jcjm 154 36 increased increase VBN cord-265139-x7g3jcjm 154 37 energy energy NN cord-265139-x7g3jcjm 154 38 expenditure expenditure NN cord-265139-x7g3jcjm 154 39 . . . cord-265139-x7g3jcjm 155 1 It -PRON- PRP cord-265139-x7g3jcjm 155 2 is be VBZ cord-265139-x7g3jcjm 155 3 worth worth JJ cord-265139-x7g3jcjm 155 4 noting note VBG cord-265139-x7g3jcjm 155 5 that that IN cord-265139-x7g3jcjm 155 6 these these DT cord-265139-x7g3jcjm 155 7 mice mouse NNS cord-265139-x7g3jcjm 155 8 also also RB cord-265139-x7g3jcjm 155 9 exhibited exhibit VBD cord-265139-x7g3jcjm 155 10 increased increase VBN cord-265139-x7g3jcjm 155 11 insulin insulin NN cord-265139-x7g3jcjm 155 12 sensitivity sensitivity NN cord-265139-x7g3jcjm 155 13 and and CC cord-265139-x7g3jcjm 155 14 glucose glucose NN cord-265139-x7g3jcjm 155 15 tolerance tolerance NN cord-265139-x7g3jcjm 155 16 [ [ -LRB- cord-265139-x7g3jcjm 155 17 74 74 CD cord-265139-x7g3jcjm 155 18 ] ] -RRB- cord-265139-x7g3jcjm 155 19 . . . cord-265139-x7g3jcjm 156 1 Mechanistically mechanistically RB cord-265139-x7g3jcjm 156 2 , , , cord-265139-x7g3jcjm 156 3 in in IN cord-265139-x7g3jcjm 156 4 vitro vitro FW cord-265139-x7g3jcjm 156 5 experiments experiment NNS cord-265139-x7g3jcjm 156 6 showed show VBD cord-265139-x7g3jcjm 156 7 that that IN cord-265139-x7g3jcjm 156 8 circSAMD4A circSAMD4A NNP cord-265139-x7g3jcjm 156 9 can can MD cord-265139-x7g3jcjm 156 10 bind bind VB cord-265139-x7g3jcjm 156 11 to to IN cord-265139-x7g3jcjm 156 12 miR-138 mir-138 JJ cord-265139-x7g3jcjm 156 13 - - HYPH cord-265139-x7g3jcjm 156 14 5p 5p NN cord-265139-x7g3jcjm 156 15 and and CC cord-265139-x7g3jcjm 156 16 act act NN cord-265139-x7g3jcjm 156 17 as as IN cord-265139-x7g3jcjm 156 18 a a DT cord-265139-x7g3jcjm 156 19 miRNA miRNA NNP cord-265139-x7g3jcjm 156 20 sponge sponge NN cord-265139-x7g3jcjm 156 21 to to TO cord-265139-x7g3jcjm 156 22 subsequently subsequently RB cord-265139-x7g3jcjm 156 23 regulate regulate VB cord-265139-x7g3jcjm 156 24 EZH2 ezh2 JJ cord-265139-x7g3jcjm 156 25 expression expression NN cord-265139-x7g3jcjm 156 26 [ [ -LRB- cord-265139-x7g3jcjm 156 27 74 74 CD cord-265139-x7g3jcjm 156 28 ] ] -RRB- cord-265139-x7g3jcjm 156 29 . . . cord-265139-x7g3jcjm 157 1 In in IN cord-265139-x7g3jcjm 157 2 humans human NNS cord-265139-x7g3jcjm 157 3 , , , cord-265139-x7g3jcjm 157 4 circSAMD4A circSAMD4A , cord-265139-x7g3jcjm 157 5 was be VBD cord-265139-x7g3jcjm 157 6 found find VBN cord-265139-x7g3jcjm 157 7 to to TO cord-265139-x7g3jcjm 157 8 be be VB cord-265139-x7g3jcjm 157 9 significantly significantly RB cord-265139-x7g3jcjm 157 10 upregulated upregulate VBN cord-265139-x7g3jcjm 157 11 in in IN cord-265139-x7g3jcjm 157 12 obese obese JJ cord-265139-x7g3jcjm 157 13 compared compare VBN cord-265139-x7g3jcjm 157 14 to to TO cord-265139-x7g3jcjm 157 15 lean lean VB cord-265139-x7g3jcjm 157 16 individuals individual NNS cord-265139-x7g3jcjm 157 17 and and CC cord-265139-x7g3jcjm 157 18 its -PRON- PRP$ cord-265139-x7g3jcjm 157 19 level level NN cord-265139-x7g3jcjm 157 20 of of IN cord-265139-x7g3jcjm 157 21 expression expression NN cord-265139-x7g3jcjm 157 22 notably notably RB cord-265139-x7g3jcjm 157 23 correlated correlate VBN cord-265139-x7g3jcjm 157 24 with with IN cord-265139-x7g3jcjm 157 25 poor poor JJ cord-265139-x7g3jcjm 157 26 prognosis prognosis NN cord-265139-x7g3jcjm 157 27 in in IN cord-265139-x7g3jcjm 157 28 obese obese JJ cord-265139-x7g3jcjm 157 29 patients patient NNS cord-265139-x7g3jcjm 157 30 [ [ -LRB- cord-265139-x7g3jcjm 157 31 74 74 CD cord-265139-x7g3jcjm 157 32 ] ] -RRB- cord-265139-x7g3jcjm 158 1 ( ( -LRB- cord-265139-x7g3jcjm 158 2 Figure figure NN cord-265139-x7g3jcjm 158 3 1 1 CD cord-265139-x7g3jcjm 158 4 ) ) -RRB- cord-265139-x7g3jcjm 158 5 . . . cord-265139-x7g3jcjm 159 1 Functional functional JJ cord-265139-x7g3jcjm 159 2 analysis analysis NN cord-265139-x7g3jcjm 159 3 confirmed confirm VBD cord-265139-x7g3jcjm 159 4 that that IN cord-265139-x7g3jcjm 159 5 circSAMD4A circSAMD4A NNP cord-265139-x7g3jcjm 159 6 overexpression overexpression NN cord-265139-x7g3jcjm 159 7 can can MD cord-265139-x7g3jcjm 159 8 regulate regulate VB cord-265139-x7g3jcjm 159 9 preadipocytes preadipocytes JJ cord-265139-x7g3jcjm 159 10 differentiation differentiation NN cord-265139-x7g3jcjm 159 11 and and CC cord-265139-x7g3jcjm 159 12 effectively effectively RB cord-265139-x7g3jcjm 159 13 predict predict VB cord-265139-x7g3jcjm 159 14 obese obese JJ cord-265139-x7g3jcjm 159 15 human human JJ cord-265139-x7g3jcjm 159 16 outcomes outcome NNS cord-265139-x7g3jcjm 159 17 . . . cord-265139-x7g3jcjm 160 1 A a DT cord-265139-x7g3jcjm 160 2 recently recently RB cord-265139-x7g3jcjm 160 3 published publish VBN cord-265139-x7g3jcjm 160 4 report report NN cord-265139-x7g3jcjm 160 5 indicated indicate VBD cord-265139-x7g3jcjm 160 6 that that IN cord-265139-x7g3jcjm 160 7 the the DT cord-265139-x7g3jcjm 160 8 expression expression NN cord-265139-x7g3jcjm 160 9 of of IN cord-265139-x7g3jcjm 160 10 two two CD cord-265139-x7g3jcjm 160 11 circRNAs circrna NNS cord-265139-x7g3jcjm 160 12 , , , cord-265139-x7g3jcjm 160 13 19:45387150|45389986 19:45387150|45389986 CD cord-265139-x7g3jcjm 160 14 and and CC cord-265139-x7g3jcjm 160 15 21:6969877|69753491 21:6969877|69753491 CD cord-265139-x7g3jcjm 160 16 , , , cord-265139-x7g3jcjm 160 17 was be VBD cord-265139-x7g3jcjm 160 18 strongly strongly RB cord-265139-x7g3jcjm 160 19 correlated correlate VBN cord-265139-x7g3jcjm 160 20 with with IN cord-265139-x7g3jcjm 160 21 fat fat JJ cord-265139-x7g3jcjm 160 22 deposition deposition NN cord-265139-x7g3jcjm 160 23 associated associate VBD cord-265139-x7g3jcjm 160 24 genes gene NNS cord-265139-x7g3jcjm 160 25 in in IN cord-265139-x7g3jcjm 160 26 Chinese chinese JJ cord-265139-x7g3jcjm 160 27 Buffalo Buffalo NNP cord-265139-x7g3jcjm 160 28 ( ( -LRB- cord-265139-x7g3jcjm 160 29 Bubalus Bubalus NNP cord-265139-x7g3jcjm 160 30 bubalis bubalis NNP cord-265139-x7g3jcjm 160 31 ) ) -RRB- cord-265139-x7g3jcjm 160 32 [ [ -LRB- cord-265139-x7g3jcjm 160 33 75 75 CD cord-265139-x7g3jcjm 160 34 ] ] -RRB- cord-265139-x7g3jcjm 160 35 . . . cord-265139-x7g3jcjm 161 1 In in IN cord-265139-x7g3jcjm 161 2 the the DT cord-265139-x7g3jcjm 161 3 same same JJ cord-265139-x7g3jcjm 161 4 context context NN cord-265139-x7g3jcjm 161 5 , , , cord-265139-x7g3jcjm 161 6 Zhang Zhang NNP cord-265139-x7g3jcjm 161 7 et et NNP cord-265139-x7g3jcjm 161 8 al al NNP cord-265139-x7g3jcjm 161 9 . . NNP cord-265139-x7g3jcjm 161 10 identified identify VBD cord-265139-x7g3jcjm 161 11 six six CD cord-265139-x7g3jcjm 161 12 circRNAs circrna NNS cord-265139-x7g3jcjm 161 13 , , , cord-265139-x7g3jcjm 161 14 novel_circ_0009127 novel_circ_0009127 NNP cord-265139-x7g3jcjm 161 15 , , , cord-265139-x7g3jcjm 161 16 novel_circ_0000628 novel_circ_0000628 NNP cord-265139-x7g3jcjm 161 17 , , , cord-265139-x7g3jcjm 161 18 novel_circ_0011513 novel_circ_0011513 NNP cord-265139-x7g3jcjm 161 19 , , , cord-265139-x7g3jcjm 161 20 novel_circ_0010775 novel_circ_0010775 NNP cord-265139-x7g3jcjm 161 21 , , , cord-265139-x7g3jcjm 161 22 novel_circ_0006981 novel_circ_0006981 NNP cord-265139-x7g3jcjm 161 23 , , , cord-265139-x7g3jcjm 161 24 and and CC cord-265139-x7g3jcjm 161 25 novel_circ_0001494 novel_circ_0001494 NNPS cord-265139-x7g3jcjm 161 26 that that WDT cord-265139-x7g3jcjm 161 27 were be VBD cord-265139-x7g3jcjm 161 28 related relate VBN cord-265139-x7g3jcjm 161 29 to to IN cord-265139-x7g3jcjm 161 30 Yac Yac NNP cord-265139-x7g3jcjm 161 31 ( ( -LRB- cord-265139-x7g3jcjm 161 32 Bos Bos NNP cord-265139-x7g3jcjm 161 33 grunniens grunniens NNP cord-265139-x7g3jcjm 161 34 ) ) -RRB- cord-265139-x7g3jcjm 161 35 adipogenesis adipogenesis NNP cord-265139-x7g3jcjm 161 36 [ [ -LRB- cord-265139-x7g3jcjm 161 37 76 76 CD cord-265139-x7g3jcjm 161 38 ] ] -RRB- cord-265139-x7g3jcjm 161 39 . . . cord-265139-x7g3jcjm 162 1 In in IN cord-265139-x7g3jcjm 162 2 cattle cattle NNS cord-265139-x7g3jcjm 162 3 adipocytes adipocyte NNS cord-265139-x7g3jcjm 162 4 , , , cord-265139-x7g3jcjm 162 5 circFUT10 circFUT10 NNP cord-265139-x7g3jcjm 162 6 was be VBD cord-265139-x7g3jcjm 162 7 found find VBN cord-265139-x7g3jcjm 162 8 to to TO cord-265139-x7g3jcjm 162 9 promote promote VB cord-265139-x7g3jcjm 162 10 adipocyte adipocyte NN cord-265139-x7g3jcjm 162 11 proliferation proliferation NN cord-265139-x7g3jcjm 162 12 and and CC cord-265139-x7g3jcjm 162 13 inhibit inhibit VB cord-265139-x7g3jcjm 162 14 adipocyte adipocyte NN cord-265139-x7g3jcjm 162 15 differentiation differentiation NN cord-265139-x7g3jcjm 162 16 via via IN cord-265139-x7g3jcjm 162 17 sponging sponge VBG cord-265139-x7g3jcjm 162 18 let-7 let-7 NN cord-265139-x7g3jcjm 162 19 binding bind VBG cord-265139-x7g3jcjm 162 20 of of IN cord-265139-x7g3jcjm 162 21 let-7c let-7c NNP cord-265139-x7g3jcjm 162 22 [ [ -LRB- cord-265139-x7g3jcjm 162 23 77 77 CD cord-265139-x7g3jcjm 162 24 ] ] -RRB- cord-265139-x7g3jcjm 162 25 . . . cord-265139-x7g3jcjm 163 1 Moreover moreover RB cord-265139-x7g3jcjm 163 2 , , , cord-265139-x7g3jcjm 163 3 ciRS-7 cirs-7 NN cord-265139-x7g3jcjm 163 4 / / SYM cord-265139-x7g3jcjm 163 5 CDR1as CDR1as NNP cord-265139-x7g3jcjm 163 6 expression expression NN cord-265139-x7g3jcjm 163 7 levels level NNS cord-265139-x7g3jcjm 163 8 were be VBD cord-265139-x7g3jcjm 163 9 decreased decrease VBN cord-265139-x7g3jcjm 163 10 both both CC cord-265139-x7g3jcjm 163 11 in in IN cord-265139-x7g3jcjm 163 12 ob ob NNP cord-265139-x7g3jcjm 163 13 / / SYM cord-265139-x7g3jcjm 163 14 ob ob NNP cord-265139-x7g3jcjm 163 15 and and CC cord-265139-x7g3jcjm 163 16 db db NNP cord-265139-x7g3jcjm 163 17 / / SYM cord-265139-x7g3jcjm 163 18 db db NNP cord-265139-x7g3jcjm 163 19 mice mouse NNS cord-265139-x7g3jcjm 163 20 , , , cord-265139-x7g3jcjm 163 21 which which WDT cord-265139-x7g3jcjm 163 22 were be VBD cord-265139-x7g3jcjm 163 23 severely severely RB cord-265139-x7g3jcjm 163 24 obese obese JJ cord-265139-x7g3jcjm 163 25 due due IN cord-265139-x7g3jcjm 163 26 to to IN cord-265139-x7g3jcjm 163 27 lack lack NN cord-265139-x7g3jcjm 163 28 of of IN cord-265139-x7g3jcjm 163 29 leptin leptin NN cord-265139-x7g3jcjm 163 30 or or CC cord-265139-x7g3jcjm 163 31 the the DT cord-265139-x7g3jcjm 163 32 leptin leptin NN cord-265139-x7g3jcjm 163 33 receptor receptor NN cord-265139-x7g3jcjm 163 34 , , , cord-265139-x7g3jcjm 163 35 respectively respectively RB cord-265139-x7g3jcjm 163 36 [ [ -LRB- cord-265139-x7g3jcjm 163 37 78 78 CD cord-265139-x7g3jcjm 163 38 ] ] -RRB- cord-265139-x7g3jcjm 163 39 . . . cord-265139-x7g3jcjm 164 1 Collectively collectively RB cord-265139-x7g3jcjm 164 2 , , , cord-265139-x7g3jcjm 164 3 these these DT cord-265139-x7g3jcjm 164 4 findings finding NNS cord-265139-x7g3jcjm 164 5 suggest suggest VBP cord-265139-x7g3jcjm 164 6 that that IN cord-265139-x7g3jcjm 164 7 circRNAs circrna NNS cord-265139-x7g3jcjm 164 8 may may MD cord-265139-x7g3jcjm 164 9 participate participate VB cord-265139-x7g3jcjm 164 10 in in IN cord-265139-x7g3jcjm 164 11 adipocyte adipocyte JJ cord-265139-x7g3jcjm 164 12 differentiation differentiation NN cord-265139-x7g3jcjm 164 13 and and CC cord-265139-x7g3jcjm 164 14 adipose adipose JJ cord-265139-x7g3jcjm 164 15 tissue tissue NN cord-265139-x7g3jcjm 164 16 formation formation NN cord-265139-x7g3jcjm 164 17 through through IN cord-265139-x7g3jcjm 164 18 post post JJ cord-265139-x7g3jcjm 164 19 - - JJ cord-265139-x7g3jcjm 164 20 transcriptional transcriptional JJ cord-265139-x7g3jcjm 164 21 regulation regulation NN cord-265139-x7g3jcjm 164 22 . . . cord-265139-x7g3jcjm 165 1 Human human JJ cord-265139-x7g3jcjm 165 2 adipose adipose JJ cord-265139-x7g3jcjm 165 3 tissue tissue NN cord-265139-x7g3jcjm 165 4 . . . cord-265139-x7g3jcjm 166 1 The the DT cord-265139-x7g3jcjm 166 2 past past JJ cord-265139-x7g3jcjm 166 3 two two CD cord-265139-x7g3jcjm 166 4 years year NNS cord-265139-x7g3jcjm 166 5 have have VBP cord-265139-x7g3jcjm 166 6 witnessed witness VBN cord-265139-x7g3jcjm 166 7 a a DT cord-265139-x7g3jcjm 166 8 significant significant JJ cord-265139-x7g3jcjm 166 9 increase increase NN cord-265139-x7g3jcjm 166 10 in in IN cord-265139-x7g3jcjm 166 11 the the DT cord-265139-x7g3jcjm 166 12 number number NN cord-265139-x7g3jcjm 166 13 of of IN cord-265139-x7g3jcjm 166 14 studies study NNS cord-265139-x7g3jcjm 166 15 determining determine VBG cord-265139-x7g3jcjm 166 16 the the DT cord-265139-x7g3jcjm 166 17 function function NN cord-265139-x7g3jcjm 166 18 of of IN cord-265139-x7g3jcjm 166 19 circRNAs circrna NNS cord-265139-x7g3jcjm 166 20 in in IN cord-265139-x7g3jcjm 166 21 human human JJ cord-265139-x7g3jcjm 166 22 adipogenesis adipogenesis NN cord-265139-x7g3jcjm 166 23 and and CC cord-265139-x7g3jcjm 166 24 obesity obesity NN cord-265139-x7g3jcjm 166 25 . . . cord-265139-x7g3jcjm 167 1 In in IN cord-265139-x7g3jcjm 167 2 a a DT cord-265139-x7g3jcjm 167 3 study study NN cord-265139-x7g3jcjm 167 4 involving involve VBG cord-265139-x7g3jcjm 167 5 visceral visceral JJ cord-265139-x7g3jcjm 167 6 adipogenesis adipogenesis NN cord-265139-x7g3jcjm 167 7 , , , cord-265139-x7g3jcjm 167 8 as as RB cord-265139-x7g3jcjm 167 9 many many JJ cord-265139-x7g3jcjm 167 10 as as IN cord-265139-x7g3jcjm 167 11 4080 4080 CD cord-265139-x7g3jcjm 167 12 circRNA circRNA NNP cord-265139-x7g3jcjm 167 13 species specie NNS cord-265139-x7g3jcjm 167 14 were be VBD cord-265139-x7g3jcjm 167 15 found find VBN cord-265139-x7g3jcjm 167 16 to to TO cord-265139-x7g3jcjm 167 17 be be VB cord-265139-x7g3jcjm 167 18 differentially differentially RB cord-265139-x7g3jcjm 167 19 expressed express VBN cord-265139-x7g3jcjm 167 20 in in IN cord-265139-x7g3jcjm 167 21 human human JJ cord-265139-x7g3jcjm 167 22 visceral visceral JJ cord-265139-x7g3jcjm 167 23 preadipocytes preadipocyte NNS cord-265139-x7g3jcjm 167 24 ( ( -LRB- cord-265139-x7g3jcjm 167 25 HPA HPA NNP cord-265139-x7g3jcjm 167 26 - - HYPH cord-265139-x7g3jcjm 167 27 v v NN cord-265139-x7g3jcjm 167 28 ) ) -RRB- cord-265139-x7g3jcjm 167 29 versus versus IN cord-265139-x7g3jcjm 167 30 HPA HPA NNP cord-265139-x7g3jcjm 167 31 - - HYPH cord-265139-x7g3jcjm 167 32 v v NN cord-265139-x7g3jcjm 167 33 that that WDT cord-265139-x7g3jcjm 167 34 were be VBD cord-265139-x7g3jcjm 167 35 induced induce VBN cord-265139-x7g3jcjm 167 36 to to TO cord-265139-x7g3jcjm 167 37 form form VB cord-265139-x7g3jcjm 167 38 adipocytes adipocyte NNS cord-265139-x7g3jcjm 167 39 ; ; : cord-265139-x7g3jcjm 167 40 among among IN cord-265139-x7g3jcjm 167 41 them -PRON- PRP cord-265139-x7g3jcjm 167 42 , , , cord-265139-x7g3jcjm 167 43 2215 2215 CD cord-265139-x7g3jcjm 167 44 and and CC cord-265139-x7g3jcjm 167 45 1865 1865 CD cord-265139-x7g3jcjm 167 46 circRNAs circrna NNS cord-265139-x7g3jcjm 167 47 were be VBD cord-265139-x7g3jcjm 167 48 significantly significantly RB cord-265139-x7g3jcjm 167 49 up up RB cord-265139-x7g3jcjm 167 50 - - : cord-265139-x7g3jcjm 167 51 and and CC cord-265139-x7g3jcjm 167 52 downregulated downregulate VBD cord-265139-x7g3jcjm 167 53 , , , cord-265139-x7g3jcjm 167 54 respectively respectively RB cord-265139-x7g3jcjm 167 55 [ [ -LRB- cord-265139-x7g3jcjm 167 56 79 79 CD cord-265139-x7g3jcjm 167 57 ] ] -RRB- cord-265139-x7g3jcjm 167 58 . . . cord-265139-x7g3jcjm 168 1 Further further JJ cord-265139-x7g3jcjm 168 2 validation validation NN cord-265139-x7g3jcjm 168 3 experiments experiment NNS cord-265139-x7g3jcjm 168 4 confirmed confirm VBD cord-265139-x7g3jcjm 168 5 that that IN cord-265139-x7g3jcjm 168 6 hsa_circ_0136134 hsa_circ_0136134 NN cord-265139-x7g3jcjm 168 7 , , , cord-265139-x7g3jcjm 168 8 hsa_circ_0017650 hsa_circ_0017650 ADD cord-265139-x7g3jcjm 168 9 , , , cord-265139-x7g3jcjm 168 10 and and CC cord-265139-x7g3jcjm 168 11 hsa hsa NNP cord-265139-x7g3jcjm 168 12 - - HYPH cord-265139-x7g3jcjm 168 13 circRNA9227 circRNA9227 NNP cord-265139-x7g3jcjm 168 14 - - HYPH cord-265139-x7g3jcjm 168 15 1 1 CD cord-265139-x7g3jcjm 168 16 were be VBD cord-265139-x7g3jcjm 168 17 the the DT cord-265139-x7g3jcjm 168 18 most most RBS cord-265139-x7g3jcjm 168 19 upregulated upregulate VBN cord-265139-x7g3jcjm 168 20 transcripts transcript NNS cord-265139-x7g3jcjm 168 21 , , , cord-265139-x7g3jcjm 168 22 suggesting suggest VBG cord-265139-x7g3jcjm 168 23 their -PRON- PRP$ cord-265139-x7g3jcjm 168 24 close close JJ cord-265139-x7g3jcjm 168 25 association association NN cord-265139-x7g3jcjm 168 26 with with IN cord-265139-x7g3jcjm 168 27 visceral visceral JJ cord-265139-x7g3jcjm 168 28 adipogenesis adipogenesis NNP cord-265139-x7g3jcjm 168 29 [ [ -LRB- cord-265139-x7g3jcjm 168 30 79 79 CD cord-265139-x7g3jcjm 168 31 ] ] -RRB- cord-265139-x7g3jcjm 168 32 . . . cord-265139-x7g3jcjm 169 1 In in IN cord-265139-x7g3jcjm 169 2 order order NN cord-265139-x7g3jcjm 169 3 to to TO cord-265139-x7g3jcjm 169 4 screen screen VB cord-265139-x7g3jcjm 169 5 circRNAs circrna NNS cord-265139-x7g3jcjm 169 6 involved involve VBN cord-265139-x7g3jcjm 169 7 in in IN cord-265139-x7g3jcjm 169 8 adipogenesis adipogenesis NN cord-265139-x7g3jcjm 169 9 and and CC cord-265139-x7g3jcjm 169 10 obesity obesity NN cord-265139-x7g3jcjm 169 11 , , , cord-265139-x7g3jcjm 169 12 Arcinas Arcinas NNP cord-265139-x7g3jcjm 169 13 and and CC cord-265139-x7g3jcjm 169 14 colleagues colleague NNS cord-265139-x7g3jcjm 169 15 analyzed analyze VBD cord-265139-x7g3jcjm 169 16 the the DT cord-265139-x7g3jcjm 169 17 transcriptome transcriptome NN cord-265139-x7g3jcjm 169 18 of of IN cord-265139-x7g3jcjm 169 19 human human NN cord-265139-x7g3jcjm 169 20 and and CC cord-265139-x7g3jcjm 169 21 mouse mouse NN cord-265139-x7g3jcjm 169 22 visceral visceral JJ cord-265139-x7g3jcjm 169 23 and and CC cord-265139-x7g3jcjm 169 24 subcutaneous subcutaneous JJ cord-265139-x7g3jcjm 169 25 fat fat NN cord-265139-x7g3jcjm 169 26 by by IN cord-265139-x7g3jcjm 169 27 RNA rna NN cord-265139-x7g3jcjm 169 28 sequencing sequencing NN cord-265139-x7g3jcjm 169 29 methods method NNS cord-265139-x7g3jcjm 169 30 [ [ -LRB- cord-265139-x7g3jcjm 169 31 80 80 CD cord-265139-x7g3jcjm 169 32 ] ] -RRB- cord-265139-x7g3jcjm 169 33 . . . cord-265139-x7g3jcjm 170 1 In in IN cord-265139-x7g3jcjm 170 2 this this DT cord-265139-x7g3jcjm 170 3 study study NN cord-265139-x7g3jcjm 170 4 , , , cord-265139-x7g3jcjm 170 5 thousands thousand NNS cord-265139-x7g3jcjm 170 6 of of IN cord-265139-x7g3jcjm 170 7 adipose adipose NN cord-265139-x7g3jcjm 170 8 circRNAs circrna NNS cord-265139-x7g3jcjm 170 9 were be VBD cord-265139-x7g3jcjm 170 10 identified identify VBN cord-265139-x7g3jcjm 170 11 to to TO cord-265139-x7g3jcjm 170 12 be be VB cord-265139-x7g3jcjm 170 13 regulated regulate VBN cord-265139-x7g3jcjm 170 14 during during IN cord-265139-x7g3jcjm 170 15 adipogenesis adipogenesis NN cord-265139-x7g3jcjm 170 16 . . . cord-265139-x7g3jcjm 171 1 Among among IN cord-265139-x7g3jcjm 171 2 these these DT cord-265139-x7g3jcjm 171 3 , , , cord-265139-x7g3jcjm 171 4 circTshz2 circTshz2 NNP cord-265139-x7g3jcjm 171 5 - - HYPH cord-265139-x7g3jcjm 171 6 1 1 CD cord-265139-x7g3jcjm 171 7 and and CC cord-265139-x7g3jcjm 171 8 circArhgap5 circArhgap5 NNS cord-265139-x7g3jcjm 171 9 - - SYM cord-265139-x7g3jcjm 171 10 2 2 CD cord-265139-x7g3jcjm 172 1 ( ( -LRB- cord-265139-x7g3jcjm 172 2 the the DT cord-265139-x7g3jcjm 172 3 regulatory regulatory JJ cord-265139-x7g3jcjm 172 4 Rho Rho NNP cord-265139-x7g3jcjm 172 5 GTPase GTPase NNP cord-265139-x7g3jcjm 172 6 activating activate VBG cord-265139-x7g3jcjm 172 7 protein protein NN cord-265139-x7g3jcjm 172 8 5 5 CD cord-265139-x7g3jcjm 172 9 - - SYM cord-265139-x7g3jcjm 172 10 2 2 CD cord-265139-x7g3jcjm 172 11 ) ) -RRB- cord-265139-x7g3jcjm 172 12 were be VBD cord-265139-x7g3jcjm 172 13 revealed reveal VBN cord-265139-x7g3jcjm 172 14 to to TO cord-265139-x7g3jcjm 172 15 be be VB cord-265139-x7g3jcjm 172 16 key key JJ cord-265139-x7g3jcjm 172 17 regulators regulator NNS cord-265139-x7g3jcjm 172 18 of of IN cord-265139-x7g3jcjm 172 19 adipogenesis adipogenesis NN cord-265139-x7g3jcjm 172 20 in in IN cord-265139-x7g3jcjm 172 21 vitro vitro FW cord-265139-x7g3jcjm 172 22 [ [ -LRB- cord-265139-x7g3jcjm 172 23 80 80 CD cord-265139-x7g3jcjm 172 24 ] ] -RRB- cord-265139-x7g3jcjm 172 25 . . . cord-265139-x7g3jcjm 173 1 Moreover moreover RB cord-265139-x7g3jcjm 173 2 , , , cord-265139-x7g3jcjm 173 3 silencing silence VBG cord-265139-x7g3jcjm 173 4 of of IN cord-265139-x7g3jcjm 173 5 circArhgap5 circArhgap5 NNS cord-265139-x7g3jcjm 173 6 - - SYM cord-265139-x7g3jcjm 173 7 2 2 CD cord-265139-x7g3jcjm 173 8 in in IN cord-265139-x7g3jcjm 173 9 vivo vivo NN cord-265139-x7g3jcjm 173 10 resulted result VBD cord-265139-x7g3jcjm 173 11 in in IN cord-265139-x7g3jcjm 173 12 inhibition inhibition NN cord-265139-x7g3jcjm 173 13 of of IN cord-265139-x7g3jcjm 173 14 lipid lipid NN cord-265139-x7g3jcjm 173 15 droplet droplet NN cord-265139-x7g3jcjm 173 16 accumulation accumulation NN cord-265139-x7g3jcjm 173 17 and and CC cord-265139-x7g3jcjm 173 18 downregulation downregulation NN cord-265139-x7g3jcjm 173 19 of of IN cord-265139-x7g3jcjm 173 20 adipogenic adipogenic JJ cord-265139-x7g3jcjm 173 21 markers marker NNS cord-265139-x7g3jcjm 173 22 suggesting suggest VBG cord-265139-x7g3jcjm 173 23 that that IN cord-265139-x7g3jcjm 173 24 circArhgap5 circArhgap5 NNS cord-265139-x7g3jcjm 173 25 - - SYM cord-265139-x7g3jcjm 173 26 2 2 CD cord-265139-x7g3jcjm 173 27 might may MD cord-265139-x7g3jcjm 173 28 have have VB cord-265139-x7g3jcjm 173 29 a a DT cord-265139-x7g3jcjm 173 30 crucial crucial JJ cord-265139-x7g3jcjm 173 31 role role NN cord-265139-x7g3jcjm 173 32 in in IN cord-265139-x7g3jcjm 173 33 maintaining maintain VBG cord-265139-x7g3jcjm 173 34 the the DT cord-265139-x7g3jcjm 173 35 global global JJ cord-265139-x7g3jcjm 173 36 adipocyte adipocyte JJ cord-265139-x7g3jcjm 173 37 transcriptional transcriptional JJ cord-265139-x7g3jcjm 173 38 program program NN cord-265139-x7g3jcjm 173 39 implicated implicate VBN cord-265139-x7g3jcjm 173 40 in in IN cord-265139-x7g3jcjm 173 41 lipid lipid NN cord-265139-x7g3jcjm 173 42 biosynthesis biosynthesis NN cord-265139-x7g3jcjm 173 43 and and CC cord-265139-x7g3jcjm 173 44 metabolism metabolism NN cord-265139-x7g3jcjm 173 45 . . . cord-265139-x7g3jcjm 174 1 Interestingly interestingly RB cord-265139-x7g3jcjm 174 2 , , , cord-265139-x7g3jcjm 174 3 the the DT cord-265139-x7g3jcjm 174 4 proadipogenic proadipogenic JJ cord-265139-x7g3jcjm 174 5 function function NN cord-265139-x7g3jcjm 174 6 of of IN cord-265139-x7g3jcjm 174 7 circArhgap5 circArhgap5 NNP cord-265139-x7g3jcjm 174 8 - - SYM cord-265139-x7g3jcjm 174 9 2 2 CD cord-265139-x7g3jcjm 174 10 was be VBD cord-265139-x7g3jcjm 174 11 found find VBN cord-265139-x7g3jcjm 174 12 to to TO cord-265139-x7g3jcjm 174 13 be be VB cord-265139-x7g3jcjm 174 14 conserved conserve VBN cord-265139-x7g3jcjm 174 15 in in IN cord-265139-x7g3jcjm 174 16 human human JJ cord-265139-x7g3jcjm 174 17 adipocytes adipocyte NNS cord-265139-x7g3jcjm 174 18 . . . cord-265139-x7g3jcjm 175 1 However however RB cord-265139-x7g3jcjm 175 2 , , , cord-265139-x7g3jcjm 175 3 the the DT cord-265139-x7g3jcjm 175 4 mechanism mechanism NN cord-265139-x7g3jcjm 175 5 by by IN cord-265139-x7g3jcjm 175 6 which which WDT cord-265139-x7g3jcjm 175 7 circArhgap5 circArhgap5 NNP cord-265139-x7g3jcjm 175 8 - - HYPH cord-265139-x7g3jcjm 175 9 2 2 CD cord-265139-x7g3jcjm 175 10 modulates modulate VBZ cord-265139-x7g3jcjm 175 11 adipogenesis adipogenesis NN cord-265139-x7g3jcjm 175 12 remains remain VBZ cord-265139-x7g3jcjm 175 13 to to TO cord-265139-x7g3jcjm 175 14 be be VB cord-265139-x7g3jcjm 175 15 determined determine VBN cord-265139-x7g3jcjm 175 16 . . . cord-265139-x7g3jcjm 176 1 These these DT cord-265139-x7g3jcjm 176 2 data datum NNS cord-265139-x7g3jcjm 176 3 robustly robustly RB cord-265139-x7g3jcjm 176 4 indicate indicate VBP cord-265139-x7g3jcjm 176 5 circRNAs circrna NNS cord-265139-x7g3jcjm 176 6 are be VBP cord-265139-x7g3jcjm 176 7 a a DT cord-265139-x7g3jcjm 176 8 contributing contribute VBG cord-265139-x7g3jcjm 176 9 factor factor NN cord-265139-x7g3jcjm 176 10 during during IN cord-265139-x7g3jcjm 176 11 adipogenesis adipogenesis NN cord-265139-x7g3jcjm 176 12 and and CC cord-265139-x7g3jcjm 176 13 adipocyte adipocyte NN cord-265139-x7g3jcjm 176 14 metabolism metabolism NN cord-265139-x7g3jcjm 176 15 . . . cord-265139-x7g3jcjm 177 1 Another another DT cord-265139-x7g3jcjm 177 2 study study NN cord-265139-x7g3jcjm 177 3 by by IN cord-265139-x7g3jcjm 177 4 Schmidt Schmidt NNP cord-265139-x7g3jcjm 177 5 et et NNP cord-265139-x7g3jcjm 177 6 al al NNP cord-265139-x7g3jcjm 177 7 . . NNP cord-265139-x7g3jcjm 177 8 reported report VBD cord-265139-x7g3jcjm 177 9 that that IN cord-265139-x7g3jcjm 177 10 the the DT cord-265139-x7g3jcjm 177 11 overexpression overexpression NN cord-265139-x7g3jcjm 177 12 of of IN cord-265139-x7g3jcjm 177 13 H19 H19 NNP cord-265139-x7g3jcjm 177 14 , , , cord-265139-x7g3jcjm 177 15 a a DT cord-265139-x7g3jcjm 177 16 maternally maternally RB cord-265139-x7g3jcjm 177 17 imprinted imprint VBN cord-265139-x7g3jcjm 177 18 lncRNA lncRNA NNP cord-265139-x7g3jcjm 177 19 that that WDT cord-265139-x7g3jcjm 177 20 plays play VBZ cord-265139-x7g3jcjm 177 21 a a DT cord-265139-x7g3jcjm 177 22 role role NN cord-265139-x7g3jcjm 177 23 in in IN cord-265139-x7g3jcjm 177 24 lipid lipid NN cord-265139-x7g3jcjm 177 25 metabolism metabolism NN cord-265139-x7g3jcjm 177 26 , , , cord-265139-x7g3jcjm 177 27 protects protect VBZ cord-265139-x7g3jcjm 177 28 against against IN cord-265139-x7g3jcjm 177 29 obesity obesity NN cord-265139-x7g3jcjm 177 30 , , , cord-265139-x7g3jcjm 177 31 and and CC cord-265139-x7g3jcjm 177 32 improves improve VBZ cord-265139-x7g3jcjm 177 33 insulin insulin NN cord-265139-x7g3jcjm 177 34 sensitivity sensitivity NN cord-265139-x7g3jcjm 177 35 [ [ -LRB- cord-265139-x7g3jcjm 177 36 81 81 CD cord-265139-x7g3jcjm 177 37 ] ] -RRB- cord-265139-x7g3jcjm 177 38 . . . cord-265139-x7g3jcjm 178 1 In in IN cord-265139-x7g3jcjm 178 2 samples sample NNS cord-265139-x7g3jcjm 178 3 from from IN cord-265139-x7g3jcjm 178 4 patients patient NNS cord-265139-x7g3jcjm 178 5 with with IN cord-265139-x7g3jcjm 178 6 metabolic metabolic JJ cord-265139-x7g3jcjm 178 7 syndrome syndrome NN cord-265139-x7g3jcjm 178 8 , , , cord-265139-x7g3jcjm 178 9 a a DT cord-265139-x7g3jcjm 178 10 condition condition NN cord-265139-x7g3jcjm 178 11 that that WDT cord-265139-x7g3jcjm 178 12 is be VBZ cord-265139-x7g3jcjm 178 13 associated associate VBN cord-265139-x7g3jcjm 178 14 with with IN cord-265139-x7g3jcjm 178 15 abdominal abdominal JJ cord-265139-x7g3jcjm 178 16 obesity obesity NN cord-265139-x7g3jcjm 178 17 and and CC cord-265139-x7g3jcjm 178 18 CVD CVD NNP cord-265139-x7g3jcjm 178 19 , , , cord-265139-x7g3jcjm 178 20 the the DT cord-265139-x7g3jcjm 178 21 level level NN cord-265139-x7g3jcjm 178 22 of of IN cord-265139-x7g3jcjm 178 23 hsa_circH19 hsa_circh19 PRP cord-265139-x7g3jcjm 178 24 derived derive VBN cord-265139-x7g3jcjm 178 25 from from IN cord-265139-x7g3jcjm 178 26 H19 H19 NNP cord-265139-x7g3jcjm 178 27 pre pre NNP cord-265139-x7g3jcjm 178 28 - - NNP cord-265139-x7g3jcjm 178 29 RNA RNA NNP cord-265139-x7g3jcjm 178 30 , , , cord-265139-x7g3jcjm 178 31 was be VBD cord-265139-x7g3jcjm 178 32 found find VBN cord-265139-x7g3jcjm 178 33 to to TO cord-265139-x7g3jcjm 178 34 be be VB cord-265139-x7g3jcjm 178 35 highly highly RB cord-265139-x7g3jcjm 178 36 increased increase VBN cord-265139-x7g3jcjm 178 37 and and CC cord-265139-x7g3jcjm 178 38 significantly significantly RB cord-265139-x7g3jcjm 178 39 correlated correlate VBN cord-265139-x7g3jcjm 178 40 with with IN cord-265139-x7g3jcjm 178 41 variables variable NNS cord-265139-x7g3jcjm 178 42 of of IN cord-265139-x7g3jcjm 178 43 adiposity adiposity NN cord-265139-x7g3jcjm 178 44 including include VBG cord-265139-x7g3jcjm 178 45 body body NN cord-265139-x7g3jcjm 178 46 mass mass NN cord-265139-x7g3jcjm 178 47 index index NN cord-265139-x7g3jcjm 178 48 ( ( -LRB- cord-265139-x7g3jcjm 178 49 BMI BMI NNP cord-265139-x7g3jcjm 178 50 ) ) -RRB- cord-265139-x7g3jcjm 178 51 , , , cord-265139-x7g3jcjm 178 52 waist waist NN cord-265139-x7g3jcjm 178 53 circumference circumference NN cord-265139-x7g3jcjm 178 54 , , , cord-265139-x7g3jcjm 178 55 fat fat JJ cord-265139-x7g3jcjm 178 56 percent percent NN cord-265139-x7g3jcjm 178 57 , , , cord-265139-x7g3jcjm 178 58 high high JJ cord-265139-x7g3jcjm 178 59 - - HYPH cord-265139-x7g3jcjm 178 60 density density NN cord-265139-x7g3jcjm 178 61 lipoprotein lipoprotein NN cord-265139-x7g3jcjm 178 62 cholesterol cholesterol NN cord-265139-x7g3jcjm 178 63 ( ( -LRB- cord-265139-x7g3jcjm 178 64 HDL HDL NNP cord-265139-x7g3jcjm 178 65 - - HYPH cord-265139-x7g3jcjm 178 66 c c NNP cord-265139-x7g3jcjm 178 67 ) ) -RRB- cord-265139-x7g3jcjm 178 68 , , , cord-265139-x7g3jcjm 178 69 and and CC cord-265139-x7g3jcjm 178 70 visceral visceral JJ cord-265139-x7g3jcjm 178 71 fat fat JJ cord-265139-x7g3jcjm 178 72 area area NN cord-265139-x7g3jcjm 178 73 [ [ -LRB- cord-265139-x7g3jcjm 178 74 82 82 CD cord-265139-x7g3jcjm 178 75 ] ] -RRB- cord-265139-x7g3jcjm 178 76 . . . cord-265139-x7g3jcjm 179 1 Conversely conversely RB cord-265139-x7g3jcjm 179 2 , , , cord-265139-x7g3jcjm 179 3 silencing silence VBG cord-265139-x7g3jcjm 179 4 of of IN cord-265139-x7g3jcjm 179 5 hsa_circH19 hsa_circh19 PRP cord-265139-x7g3jcjm 179 6 promoted promote VBN cord-265139-x7g3jcjm 179 7 human human JJ cord-265139-x7g3jcjm 179 8 adipose adipose NN cord-265139-x7g3jcjm 179 9 - - HYPH cord-265139-x7g3jcjm 179 10 derived derive VBN cord-265139-x7g3jcjm 179 11 stem stem NN cord-265139-x7g3jcjm 179 12 cells cell NNS cord-265139-x7g3jcjm 179 13 ( ( -LRB- cord-265139-x7g3jcjm 179 14 hADSCs hadscs NN cord-265139-x7g3jcjm 179 15 ) ) -RRB- cord-265139-x7g3jcjm 179 16 adipogenic adipogenic JJ cord-265139-x7g3jcjm 179 17 differentiation differentiation NN cord-265139-x7g3jcjm 179 18 presumably presumably RB cord-265139-x7g3jcjm 179 19 through through IN cord-265139-x7g3jcjm 179 20 the the DT cord-265139-x7g3jcjm 179 21 interaction interaction NN cord-265139-x7g3jcjm 179 22 of of IN cord-265139-x7g3jcjm 179 23 such such PDT cord-265139-x7g3jcjm 179 24 a a DT cord-265139-x7g3jcjm 179 25 circRNA circrna NN cord-265139-x7g3jcjm 179 26 with with IN cord-265139-x7g3jcjm 179 27 polypyrimidine polypyrimidine JJ cord-265139-x7g3jcjm 179 28 tract tract NN cord-265139-x7g3jcjm 179 29 - - HYPH cord-265139-x7g3jcjm 179 30 binding bind VBG cord-265139-x7g3jcjm 179 31 protein protein NN cord-265139-x7g3jcjm 179 32 1 1 CD cord-265139-x7g3jcjm 179 33 ( ( -LRB- cord-265139-x7g3jcjm 179 34 PTBP1 PTBP1 NNS cord-265139-x7g3jcjm 179 35 ) ) -RRB- cord-265139-x7g3jcjm 180 1 [ [ -LRB- cord-265139-x7g3jcjm 180 2 82 82 CD cord-265139-x7g3jcjm 180 3 ] ] -RRB- cord-265139-x7g3jcjm 180 4 . . . cord-265139-x7g3jcjm 181 1 Another another DT cord-265139-x7g3jcjm 181 2 circRNA circrna NN cord-265139-x7g3jcjm 181 3 that that WDT cord-265139-x7g3jcjm 181 4 has have VBZ cord-265139-x7g3jcjm 181 5 attracted attract VBN cord-265139-x7g3jcjm 181 6 substantial substantial JJ cord-265139-x7g3jcjm 181 7 attention attention NN cord-265139-x7g3jcjm 181 8 for for IN cord-265139-x7g3jcjm 181 9 its -PRON- PRP$ cord-265139-x7g3jcjm 181 10 role role NN cord-265139-x7g3jcjm 181 11 in in IN cord-265139-x7g3jcjm 181 12 various various JJ cord-265139-x7g3jcjm 181 13 physiopathological physiopathological JJ cord-265139-x7g3jcjm 181 14 processes process NNS cord-265139-x7g3jcjm 181 15 is be VBZ cord-265139-x7g3jcjm 181 16 circular circular JJ cord-265139-x7g3jcjm 181 17 antisense antisense NNP cord-265139-x7g3jcjm 181 18 noncoding noncoding NNP cord-265139-x7g3jcjm 181 19 RNA RNA NNP cord-265139-x7g3jcjm 181 20 at at IN cord-265139-x7g3jcjm 181 21 the the DT cord-265139-x7g3jcjm 181 22 INK4 INK4 NNP cord-265139-x7g3jcjm 181 23 locus locus NN cord-265139-x7g3jcjm 181 24 ( ( -LRB- cord-265139-x7g3jcjm 181 25 circANRIL circANRIL NNP cord-265139-x7g3jcjm 181 26 ) ) -RRB- cord-265139-x7g3jcjm 181 27 . . . cord-265139-x7g3jcjm 182 1 Genetic genetic JJ cord-265139-x7g3jcjm 182 2 variants variant NNS cord-265139-x7g3jcjm 182 3 at at IN cord-265139-x7g3jcjm 182 4 the the DT cord-265139-x7g3jcjm 182 5 ANRIL ANRIL NNP cord-265139-x7g3jcjm 182 6 gene gene NN cord-265139-x7g3jcjm 182 7 have have VBP cord-265139-x7g3jcjm 182 8 been be VBN cord-265139-x7g3jcjm 182 9 linked link VBN cord-265139-x7g3jcjm 182 10 with with IN cord-265139-x7g3jcjm 182 11 increased increase VBN cord-265139-x7g3jcjm 182 12 risk risk NN cord-265139-x7g3jcjm 182 13 for for IN cord-265139-x7g3jcjm 182 14 T2DM T2DM NNP cord-265139-x7g3jcjm 182 15 , , , cord-265139-x7g3jcjm 182 16 atherosclerotic atherosclerotic JJ cord-265139-x7g3jcjm 182 17 CVD CVD NNP cord-265139-x7g3jcjm 182 18 , , , cord-265139-x7g3jcjm 182 19 coronary coronary JJ cord-265139-x7g3jcjm 182 20 artery artery NN cord-265139-x7g3jcjm 182 21 disease disease NN cord-265139-x7g3jcjm 182 22 , , , cord-265139-x7g3jcjm 182 23 myocardial myocardial JJ cord-265139-x7g3jcjm 182 24 infarction infarction NN cord-265139-x7g3jcjm 182 25 , , , cord-265139-x7g3jcjm 182 26 and and CC cord-265139-x7g3jcjm 182 27 obesity obesity NN cord-265139-x7g3jcjm 182 28 [ [ -LRB- cord-265139-x7g3jcjm 182 29 83 83 CD cord-265139-x7g3jcjm 182 30 ] ] -RRB- cord-265139-x7g3jcjm 182 31 [ [ -LRB- cord-265139-x7g3jcjm 182 32 84 84 CD cord-265139-x7g3jcjm 182 33 ] ] -RRB- cord-265139-x7g3jcjm 182 34 [ [ -LRB- cord-265139-x7g3jcjm 182 35 85 85 CD cord-265139-x7g3jcjm 182 36 ] ] -RRB- cord-265139-x7g3jcjm 182 37 . . . cord-265139-x7g3jcjm 183 1 Further further JJ cord-265139-x7g3jcjm 183 2 studies study NNS cord-265139-x7g3jcjm 183 3 have have VBP cord-265139-x7g3jcjm 183 4 demonstrated demonstrate VBN cord-265139-x7g3jcjm 183 5 that that IN cord-265139-x7g3jcjm 183 6 epigenetic epigenetic JJ cord-265139-x7g3jcjm 183 7 regulation regulation NN cord-265139-x7g3jcjm 183 8 of of IN cord-265139-x7g3jcjm 183 9 ANRIL anril JJ cord-265139-x7g3jcjm 183 10 promoter promoter NN cord-265139-x7g3jcjm 183 11 methylation methylation NN cord-265139-x7g3jcjm 183 12 at at IN cord-265139-x7g3jcjm 183 13 birth birth NN cord-265139-x7g3jcjm 183 14 is be VBZ cord-265139-x7g3jcjm 183 15 associated associate VBN cord-265139-x7g3jcjm 183 16 with with IN cord-265139-x7g3jcjm 183 17 increased increase VBN cord-265139-x7g3jcjm 183 18 cardiovascular cardiovascular JJ cord-265139-x7g3jcjm 183 19 risk risk NN cord-265139-x7g3jcjm 183 20 [ [ -LRB- cord-265139-x7g3jcjm 183 21 86 86 CD cord-265139-x7g3jcjm 183 22 ] ] -RRB- cord-265139-x7g3jcjm 183 23 and and CC cord-265139-x7g3jcjm 183 24 later later RB cord-265139-x7g3jcjm 183 25 childhood childhood NN cord-265139-x7g3jcjm 183 26 adiposity adiposity NN cord-265139-x7g3jcjm 183 27 [ [ -LRB- cord-265139-x7g3jcjm 183 28 87 87 CD cord-265139-x7g3jcjm 183 29 ] ] -RRB- cord-265139-x7g3jcjm 183 30 . . . cord-265139-x7g3jcjm 184 1 Hence hence RB cord-265139-x7g3jcjm 184 2 , , , cord-265139-x7g3jcjm 184 3 perinatal perinatal JJ cord-265139-x7g3jcjm 184 4 methylation methylation NN cord-265139-x7g3jcjm 184 5 at at IN cord-265139-x7g3jcjm 184 6 ANRIL anril JJ cord-265139-x7g3jcjm 184 7 loci locus NNS cord-265139-x7g3jcjm 184 8 could could MD cord-265139-x7g3jcjm 184 9 be be VB cord-265139-x7g3jcjm 184 10 a a DT cord-265139-x7g3jcjm 184 11 marker marker NN cord-265139-x7g3jcjm 184 12 for for IN cord-265139-x7g3jcjm 184 13 later later JJ cord-265139-x7g3jcjm 184 14 adiposity adiposity NN cord-265139-x7g3jcjm 184 15 . . . cord-265139-x7g3jcjm 185 1 Collectively collectively RB cord-265139-x7g3jcjm 185 2 , , , cord-265139-x7g3jcjm 185 3 the the DT cord-265139-x7g3jcjm 185 4 results result NNS cord-265139-x7g3jcjm 185 5 from from IN cord-265139-x7g3jcjm 185 6 the the DT cord-265139-x7g3jcjm 185 7 above above JJ cord-265139-x7g3jcjm 185 8 studies study NNS cord-265139-x7g3jcjm 185 9 demonstrate demonstrate VBP cord-265139-x7g3jcjm 185 10 that that IN cord-265139-x7g3jcjm 185 11 several several JJ cord-265139-x7g3jcjm 185 12 circRNAs circrna NNS cord-265139-x7g3jcjm 185 13 are be VBP cord-265139-x7g3jcjm 185 14 differentially differentially RB cord-265139-x7g3jcjm 185 15 expressed express VBN cord-265139-x7g3jcjm 185 16 in in IN cord-265139-x7g3jcjm 185 17 adipose adipose JJ cord-265139-x7g3jcjm 185 18 tissue tissue NN cord-265139-x7g3jcjm 185 19 and and CC cord-265139-x7g3jcjm 185 20 support support VB cord-265139-x7g3jcjm 185 21 a a DT cord-265139-x7g3jcjm 185 22 significant significant JJ cord-265139-x7g3jcjm 185 23 role role NN cord-265139-x7g3jcjm 185 24 of of IN cord-265139-x7g3jcjm 185 25 these these DT cord-265139-x7g3jcjm 185 26 RNA RNA NNP cord-265139-x7g3jcjm 185 27 species specie NNS cord-265139-x7g3jcjm 185 28 in in IN cord-265139-x7g3jcjm 185 29 the the DT cord-265139-x7g3jcjm 185 30 regulatory regulatory JJ cord-265139-x7g3jcjm 185 31 networks network NNS cord-265139-x7g3jcjm 185 32 of of IN cord-265139-x7g3jcjm 185 33 adipogenesis adipogenesis NNP cord-265139-x7g3jcjm 185 34 . . . cord-265139-x7g3jcjm 186 1 However however RB cord-265139-x7g3jcjm 186 2 , , , cord-265139-x7g3jcjm 186 3 the the DT cord-265139-x7g3jcjm 186 4 precise precise JJ cord-265139-x7g3jcjm 186 5 role role NN cord-265139-x7g3jcjm 186 6 that that WDT cord-265139-x7g3jcjm 186 7 circRNAs circrna NNS cord-265139-x7g3jcjm 186 8 play play VBP cord-265139-x7g3jcjm 186 9 in in IN cord-265139-x7g3jcjm 186 10 fat fat JJ cord-265139-x7g3jcjm 186 11 deposition deposition NN cord-265139-x7g3jcjm 186 12 and and CC cord-265139-x7g3jcjm 186 13 lipid lipid NN cord-265139-x7g3jcjm 186 14 metabolism metabolism NN cord-265139-x7g3jcjm 186 15 remains remain VBZ cord-265139-x7g3jcjm 186 16 elusive elusive JJ cord-265139-x7g3jcjm 186 17 . . . cord-265139-x7g3jcjm 187 1 Deeper deep JJR cord-265139-x7g3jcjm 187 2 understanding understanding NN cord-265139-x7g3jcjm 187 3 of of IN cord-265139-x7g3jcjm 187 4 molecular molecular JJ cord-265139-x7g3jcjm 187 5 mechanisms mechanism NNS cord-265139-x7g3jcjm 187 6 controlling control VBG cord-265139-x7g3jcjm 187 7 the the DT cord-265139-x7g3jcjm 187 8 expression expression NN cord-265139-x7g3jcjm 187 9 of of IN cord-265139-x7g3jcjm 187 10 these these DT cord-265139-x7g3jcjm 187 11 RNAs rna NNS cord-265139-x7g3jcjm 187 12 species specie NNS cord-265139-x7g3jcjm 187 13 is be VBZ cord-265139-x7g3jcjm 187 14 critical critical JJ cord-265139-x7g3jcjm 187 15 to to TO cord-265139-x7g3jcjm 187 16 identify identify VB cord-265139-x7g3jcjm 187 17 new new JJ cord-265139-x7g3jcjm 187 18 targets target NNS cord-265139-x7g3jcjm 187 19 for for IN cord-265139-x7g3jcjm 187 20 prevention prevention NN cord-265139-x7g3jcjm 187 21 of of IN cord-265139-x7g3jcjm 187 22 adipogenesis adipogenesis NN cord-265139-x7g3jcjm 187 23 and and CC cord-265139-x7g3jcjm 187 24 therefore therefore RB cord-265139-x7g3jcjm 187 25 occurrence occurrence NN cord-265139-x7g3jcjm 187 26 of of IN cord-265139-x7g3jcjm 187 27 obesity obesity NN cord-265139-x7g3jcjm 187 28 and and CC cord-265139-x7g3jcjm 187 29 obesity obesity NN cord-265139-x7g3jcjm 187 30 - - HYPH cord-265139-x7g3jcjm 187 31 related relate VBN cord-265139-x7g3jcjm 187 32 metabolic metabolic JJ cord-265139-x7g3jcjm 187 33 disorders disorder NNS cord-265139-x7g3jcjm 187 34 . . . cord-265139-x7g3jcjm 188 1 It -PRON- PRP cord-265139-x7g3jcjm 188 2 is be VBZ cord-265139-x7g3jcjm 188 3 widely widely RB cord-265139-x7g3jcjm 188 4 agreed agree VBN cord-265139-x7g3jcjm 188 5 that that IN cord-265139-x7g3jcjm 188 6 IR IR NNP cord-265139-x7g3jcjm 188 7 is be VBZ cord-265139-x7g3jcjm 188 8 strongly strongly RB cord-265139-x7g3jcjm 188 9 associated associate VBN cord-265139-x7g3jcjm 188 10 with with IN cord-265139-x7g3jcjm 188 11 obesity obesity NN cord-265139-x7g3jcjm 188 12 and and CC cord-265139-x7g3jcjm 188 13 T2DM T2DM NNP cord-265139-x7g3jcjm 188 14 , , , cord-265139-x7g3jcjm 188 15 although although IN cord-265139-x7g3jcjm 188 16 not not RB cord-265139-x7g3jcjm 188 17 all all DT cord-265139-x7g3jcjm 188 18 individuals individual NNS cord-265139-x7g3jcjm 188 19 with with IN cord-265139-x7g3jcjm 188 20 obesity obesity NN cord-265139-x7g3jcjm 188 21 develop develop VBP cord-265139-x7g3jcjm 188 22 IR IR NNP cord-265139-x7g3jcjm 188 23 . . . cord-265139-x7g3jcjm 189 1 Overwhelming overwhelming JJ cord-265139-x7g3jcjm 189 2 evidence evidence NN cord-265139-x7g3jcjm 189 3 suggests suggest VBZ cord-265139-x7g3jcjm 189 4 that that IN cord-265139-x7g3jcjm 189 5 obesity obesity NN cord-265139-x7g3jcjm 189 6 - - HYPH cord-265139-x7g3jcjm 189 7 induced induce VBN cord-265139-x7g3jcjm 189 8 inflammation inflammation NN cord-265139-x7g3jcjm 189 9 is be VBZ cord-265139-x7g3jcjm 189 10 characterized characterize VBN cord-265139-x7g3jcjm 189 11 by by IN cord-265139-x7g3jcjm 189 12 the the DT cord-265139-x7g3jcjm 189 13 abundance abundance NN cord-265139-x7g3jcjm 189 14 of of IN cord-265139-x7g3jcjm 189 15 immune immune JJ cord-265139-x7g3jcjm 189 16 cells cell NNS cord-265139-x7g3jcjm 189 17 , , , cord-265139-x7g3jcjm 189 18 which which WDT cord-265139-x7g3jcjm 189 19 increase increase VBP cord-265139-x7g3jcjm 189 20 secretion secretion NN cord-265139-x7g3jcjm 189 21 of of IN cord-265139-x7g3jcjm 189 22 proinflammatory proinflammatory JJ cord-265139-x7g3jcjm 189 23 cytokines cytokine NNS cord-265139-x7g3jcjm 189 24 that that WDT cord-265139-x7g3jcjm 189 25 act act VBP cord-265139-x7g3jcjm 189 26 to to TO cord-265139-x7g3jcjm 189 27 perpetuate perpetuate VB cord-265139-x7g3jcjm 189 28 systemic systemic JJ cord-265139-x7g3jcjm 189 29 inflammation inflammation NN cord-265139-x7g3jcjm 189 30 , , , cord-265139-x7g3jcjm 189 31 impair impair VB cord-265139-x7g3jcjm 189 32 glucose glucose NN cord-265139-x7g3jcjm 189 33 tolerance tolerance NN cord-265139-x7g3jcjm 189 34 , , , cord-265139-x7g3jcjm 189 35 and and CC cord-265139-x7g3jcjm 189 36 cause cause VB cord-265139-x7g3jcjm 189 37 IR IR NNP cord-265139-x7g3jcjm 189 38 leading lead VBG cord-265139-x7g3jcjm 189 39 to to IN cord-265139-x7g3jcjm 189 40 the the DT cord-265139-x7g3jcjm 189 41 development development NN cord-265139-x7g3jcjm 189 42 of of IN cord-265139-x7g3jcjm 189 43 T2DM T2DM NNP cord-265139-x7g3jcjm 189 44 [ [ -LRB- cord-265139-x7g3jcjm 189 45 88 88 CD cord-265139-x7g3jcjm 189 46 ] ] -RRB- cord-265139-x7g3jcjm 189 47 . . . cord-265139-x7g3jcjm 190 1 Furthermore furthermore RB cord-265139-x7g3jcjm 190 2 , , , cord-265139-x7g3jcjm 190 3 the the DT cord-265139-x7g3jcjm 190 4 role role NN cord-265139-x7g3jcjm 190 5 of of IN cord-265139-x7g3jcjm 190 6 ncRNAs ncRNAs NNP cord-265139-x7g3jcjm 190 7 in in IN cord-265139-x7g3jcjm 190 8 the the DT cord-265139-x7g3jcjm 190 9 regulation regulation NN cord-265139-x7g3jcjm 190 10 of of IN cord-265139-x7g3jcjm 190 11 obesity obesity NN cord-265139-x7g3jcjm 190 12 and and CC cord-265139-x7g3jcjm 190 13 IR IR NNP cord-265139-x7g3jcjm 190 14 has have VBZ cord-265139-x7g3jcjm 190 15 been be VBN cord-265139-x7g3jcjm 190 16 already already RB cord-265139-x7g3jcjm 190 17 reported report VBN cord-265139-x7g3jcjm 190 18 [ [ -LRB- cord-265139-x7g3jcjm 190 19 89 89 CD cord-265139-x7g3jcjm 190 20 , , , cord-265139-x7g3jcjm 190 21 90 90 CD cord-265139-x7g3jcjm 190 22 ] ] -RRB- cord-265139-x7g3jcjm 190 23 . . . cord-265139-x7g3jcjm 191 1 For for IN cord-265139-x7g3jcjm 191 2 instance instance NN cord-265139-x7g3jcjm 191 3 , , , cord-265139-x7g3jcjm 191 4 miR-33 miR-33 NNP cord-265139-x7g3jcjm 191 5 has have VBZ cord-265139-x7g3jcjm 191 6 been be VBN cord-265139-x7g3jcjm 191 7 shown show VBN cord-265139-x7g3jcjm 191 8 to to TO cord-265139-x7g3jcjm 191 9 play play VB cord-265139-x7g3jcjm 191 10 a a DT cord-265139-x7g3jcjm 191 11 crucial crucial JJ cord-265139-x7g3jcjm 191 12 function function NN cord-265139-x7g3jcjm 191 13 in in IN cord-265139-x7g3jcjm 191 14 IR IR NNP cord-265139-x7g3jcjm 191 15 and and CC cord-265139-x7g3jcjm 191 16 obesity obesity NN cord-265139-x7g3jcjm 191 17 [ [ -LRB- cord-265139-x7g3jcjm 191 18 91 91 CD cord-265139-x7g3jcjm 191 19 ] ] -RRB- cord-265139-x7g3jcjm 191 20 . . . cord-265139-x7g3jcjm 192 1 In in IN cord-265139-x7g3jcjm 192 2 humans human NNS cord-265139-x7g3jcjm 192 3 , , , cord-265139-x7g3jcjm 192 4 miR-122 miR-122 NNP cord-265139-x7g3jcjm 192 5 , , , cord-265139-x7g3jcjm 192 6 miR-143 miR-143 NNP cord-265139-x7g3jcjm 192 7 - - HYPH cord-265139-x7g3jcjm 192 8 3p 3p CD cord-265139-x7g3jcjm 192 9 , , , cord-265139-x7g3jcjm 192 10 and and CC cord-265139-x7g3jcjm 192 11 miR-652 miR-652 NNP cord-265139-x7g3jcjm 192 12 - - HYPH cord-265139-x7g3jcjm 192 13 3p 3p CD cord-265139-x7g3jcjm 192 14 have have VBP cord-265139-x7g3jcjm 192 15 also also RB cord-265139-x7g3jcjm 192 16 been be VBN cord-265139-x7g3jcjm 192 17 reportedly reportedly RB cord-265139-x7g3jcjm 192 18 linked link VBN cord-265139-x7g3jcjm 192 19 with with IN cord-265139-x7g3jcjm 192 20 obesity obesity NN cord-265139-x7g3jcjm 192 21 and and CC cord-265139-x7g3jcjm 192 22 IR IR NNP cord-265139-x7g3jcjm 192 23 and and CC cord-265139-x7g3jcjm 192 24 implicated implicate VBN cord-265139-x7g3jcjm 192 25 in in IN cord-265139-x7g3jcjm 192 26 the the DT cord-265139-x7g3jcjm 192 27 modulation modulation NN cord-265139-x7g3jcjm 192 28 of of IN cord-265139-x7g3jcjm 192 29 genes gene NNS cord-265139-x7g3jcjm 192 30 and and CC cord-265139-x7g3jcjm 192 31 protein protein NN cord-265139-x7g3jcjm 192 32 cascades cascade NNS cord-265139-x7g3jcjm 192 33 in in IN cord-265139-x7g3jcjm 192 34 insulin insulin NN cord-265139-x7g3jcjm 192 35 signaling signal VBG cord-265139-x7g3jcjm 192 36 [ [ -LRB- cord-265139-x7g3jcjm 192 37 92 92 CD cord-265139-x7g3jcjm 192 38 ] ] -RRB- cord-265139-x7g3jcjm 192 39 . . . cord-265139-x7g3jcjm 193 1 Furthermore furthermore RB cord-265139-x7g3jcjm 193 2 , , , cord-265139-x7g3jcjm 193 3 altered altered JJ cord-265139-x7g3jcjm 193 4 expression expression NN cord-265139-x7g3jcjm 193 5 of of IN cord-265139-x7g3jcjm 193 6 lncRNAs lncRNAs NNP cord-265139-x7g3jcjm 193 7 has have VBZ cord-265139-x7g3jcjm 193 8 been be VBN cord-265139-x7g3jcjm 193 9 associated associate VBN cord-265139-x7g3jcjm 193 10 with with IN cord-265139-x7g3jcjm 193 11 poor poor JJ cord-265139-x7g3jcjm 193 12 glycemic glycemic NN cord-265139-x7g3jcjm 193 13 control control NN cord-265139-x7g3jcjm 193 14 , , , cord-265139-x7g3jcjm 193 15 IR IR NNP cord-265139-x7g3jcjm 193 16 , , , cord-265139-x7g3jcjm 193 17 accelerated accelerate VBD cord-265139-x7g3jcjm 193 18 cellular cellular JJ cord-265139-x7g3jcjm 193 19 senescence senescence NN cord-265139-x7g3jcjm 193 20 , , , cord-265139-x7g3jcjm 193 21 and and CC cord-265139-x7g3jcjm 193 22 inflammation inflammation NN cord-265139-x7g3jcjm 193 23 in in IN cord-265139-x7g3jcjm 193 24 diabetes diabetes NN cord-265139-x7g3jcjm 193 25 patients patient NNS cord-265139-x7g3jcjm 193 26 [ [ -LRB- cord-265139-x7g3jcjm 193 27 93 93 CD cord-265139-x7g3jcjm 193 28 ] ] -RRB- cord-265139-x7g3jcjm 193 29 . . . cord-265139-x7g3jcjm 194 1 Up up IN cord-265139-x7g3jcjm 194 2 to to IN cord-265139-x7g3jcjm 194 3 now now RB cord-265139-x7g3jcjm 194 4 , , , cord-265139-x7g3jcjm 194 5 no no DT cord-265139-x7g3jcjm 194 6 studies study NNS cord-265139-x7g3jcjm 194 7 have have VBP cord-265139-x7g3jcjm 194 8 specifically specifically RB cord-265139-x7g3jcjm 194 9 exploited exploit VBN cord-265139-x7g3jcjm 194 10 the the DT cord-265139-x7g3jcjm 194 11 role role NN cord-265139-x7g3jcjm 194 12 of of IN cord-265139-x7g3jcjm 194 13 circRNAs circrna NNS cord-265139-x7g3jcjm 194 14 in in IN cord-265139-x7g3jcjm 194 15 obesity obesity NN cord-265139-x7g3jcjm 194 16 - - HYPH cord-265139-x7g3jcjm 194 17 IR IR NNP cord-265139-x7g3jcjm 194 18 - - HYPH cord-265139-x7g3jcjm 194 19 T2DM T2DM NNP cord-265139-x7g3jcjm 194 20 settings setting NNS cord-265139-x7g3jcjm 194 21 , , , cord-265139-x7g3jcjm 194 22 but but CC cord-265139-x7g3jcjm 194 23 this this DT cord-265139-x7g3jcjm 194 24 scenario scenario NN cord-265139-x7g3jcjm 194 25 will will MD cord-265139-x7g3jcjm 194 26 likely likely RB cord-265139-x7g3jcjm 194 27 change change VB cord-265139-x7g3jcjm 194 28 in in IN cord-265139-x7g3jcjm 194 29 the the DT cord-265139-x7g3jcjm 194 30 future future NN cord-265139-x7g3jcjm 194 31 as as IN cord-265139-x7g3jcjm 194 32 alterations alteration NNS cord-265139-x7g3jcjm 194 33 in in IN cord-265139-x7g3jcjm 194 34 many many JJ cord-265139-x7g3jcjm 194 35 circRNAs circrna NNS cord-265139-x7g3jcjm 194 36 in in IN cord-265139-x7g3jcjm 194 37 association association NN cord-265139-x7g3jcjm 194 38 with with IN cord-265139-x7g3jcjm 194 39 IR IR NNP cord-265139-x7g3jcjm 194 40 have have VBP cord-265139-x7g3jcjm 194 41 been be VBN cord-265139-x7g3jcjm 194 42 noticed notice VBN cord-265139-x7g3jcjm 194 43 . . . cord-265139-x7g3jcjm 195 1 For for IN cord-265139-x7g3jcjm 195 2 instance instance NN cord-265139-x7g3jcjm 195 3 , , , cord-265139-x7g3jcjm 195 4 circHIPK3 circhipk3 NN cord-265139-x7g3jcjm 195 5 has have VBZ cord-265139-x7g3jcjm 195 6 been be VBN cord-265139-x7g3jcjm 195 7 shown show VBN cord-265139-x7g3jcjm 195 8 to to TO cord-265139-x7g3jcjm 195 9 contribute contribute VB cord-265139-x7g3jcjm 195 10 to to IN cord-265139-x7g3jcjm 195 11 hyperglycemia hyperglycemia NN cord-265139-x7g3jcjm 195 12 and and CC cord-265139-x7g3jcjm 195 13 IR IR NNP cord-265139-x7g3jcjm 195 14 via via IN cord-265139-x7g3jcjm 195 15 sponging sponging NN cord-265139-x7g3jcjm 195 16 miR-192 mir-192 NN cord-265139-x7g3jcjm 195 17 - - : cord-265139-x7g3jcjm 195 18 5p 5p NN cord-265139-x7g3jcjm 195 19 and and CC cord-265139-x7g3jcjm 195 20 upregulating upregulating NN cord-265139-x7g3jcjm 195 21 FOXO1 foxo1 XX cord-265139-x7g3jcjm 195 22 [ [ -LRB- cord-265139-x7g3jcjm 195 23 94 94 CD cord-265139-x7g3jcjm 195 24 ] ] -RRB- cord-265139-x7g3jcjm 195 25 . . . cord-265139-x7g3jcjm 196 1 It -PRON- PRP cord-265139-x7g3jcjm 196 2 noteworthy noteworthy JJ cord-265139-x7g3jcjm 196 3 to to TO cord-265139-x7g3jcjm 196 4 mention mention VB cord-265139-x7g3jcjm 196 5 that that IN cord-265139-x7g3jcjm 196 6 circHIPK3 circhipk3 NN cord-265139-x7g3jcjm 196 7 has have VBZ cord-265139-x7g3jcjm 196 8 already already RB cord-265139-x7g3jcjm 196 9 been be VBN cord-265139-x7g3jcjm 196 10 demonstrated demonstrate VBN cord-265139-x7g3jcjm 196 11 to to TO cord-265139-x7g3jcjm 196 12 play play VB cord-265139-x7g3jcjm 196 13 a a DT cord-265139-x7g3jcjm 196 14 crucial crucial JJ cord-265139-x7g3jcjm 196 15 role role NN cord-265139-x7g3jcjm 196 16 in in IN cord-265139-x7g3jcjm 196 17 diabetes diabetes NN cord-265139-x7g3jcjm 196 18 retinas retina NNS cord-265139-x7g3jcjm 196 19 by by IN cord-265139-x7g3jcjm 196 20 virtue virtue NN cord-265139-x7g3jcjm 196 21 of of IN cord-265139-x7g3jcjm 196 22 its -PRON- PRP$ cord-265139-x7g3jcjm 196 23 effect effect NN cord-265139-x7g3jcjm 196 24 on on IN cord-265139-x7g3jcjm 196 25 miR-30a-3p mir-30a-3p XX cord-265139-x7g3jcjm 196 26 [ [ -LRB- cord-265139-x7g3jcjm 196 27 95 95 CD cord-265139-x7g3jcjm 196 28 ] ] -RRB- cord-265139-x7g3jcjm 196 29 . . . cord-265139-x7g3jcjm 197 1 circRNA circRNA NNP cord-265139-x7g3jcjm 198 1 -TFRC -TFRC : cord-265139-x7g3jcjm 198 2 ( ( -LRB- cord-265139-x7g3jcjm 198 3 transferrin transferrin NN cord-265139-x7g3jcjm 198 4 receptor receptor NN cord-265139-x7g3jcjm 198 5 ) ) -RRB- cord-265139-x7g3jcjm 198 6 has have VBZ cord-265139-x7g3jcjm 198 7 also also RB cord-265139-x7g3jcjm 198 8 been be VBN cord-265139-x7g3jcjm 198 9 associated associate VBN cord-265139-x7g3jcjm 198 10 with with IN cord-265139-x7g3jcjm 198 11 IR IR NNP cord-265139-x7g3jcjm 198 12 , , , cord-265139-x7g3jcjm 198 13 and and CC cord-265139-x7g3jcjm 198 14 the the DT cord-265139-x7g3jcjm 198 15 overexpression overexpression NN cord-265139-x7g3jcjm 198 16 of of IN cord-265139-x7g3jcjm 198 17 TFRC TFRC NNP cord-265139-x7g3jcjm 198 18 can can MD cord-265139-x7g3jcjm 198 19 aggravate aggravate VB cord-265139-x7g3jcjm 198 20 the the DT cord-265139-x7g3jcjm 198 21 risk risk NN cord-265139-x7g3jcjm 198 22 of of IN cord-265139-x7g3jcjm 198 23 T2DM T2DM NNP cord-265139-x7g3jcjm 198 24 and and CC cord-265139-x7g3jcjm 198 25 metabolic metabolic JJ cord-265139-x7g3jcjm 198 26 diseases disease NNS cord-265139-x7g3jcjm 198 27 [ [ -LRB- cord-265139-x7g3jcjm 198 28 96 96 CD cord-265139-x7g3jcjm 198 29 ] ] -RRB- cord-265139-x7g3jcjm 198 30 . . . cord-265139-x7g3jcjm 199 1 Even even RB cord-265139-x7g3jcjm 199 2 though though IN cord-265139-x7g3jcjm 199 3 these these DT cord-265139-x7g3jcjm 199 4 studies study NNS cord-265139-x7g3jcjm 199 5 do do VBP cord-265139-x7g3jcjm 199 6 not not RB cord-265139-x7g3jcjm 199 7 provide provide VB cord-265139-x7g3jcjm 199 8 a a DT cord-265139-x7g3jcjm 199 9 direct direct JJ cord-265139-x7g3jcjm 199 10 link link NN cord-265139-x7g3jcjm 199 11 between between IN cord-265139-x7g3jcjm 199 12 potential potential JJ cord-265139-x7g3jcjm 199 13 circRNA circrna NN cord-265139-x7g3jcjm 199 14 signatures signature NNS cord-265139-x7g3jcjm 199 15 and and CC cord-265139-x7g3jcjm 199 16 obesity obesity NN cord-265139-x7g3jcjm 199 17 - - HYPH cord-265139-x7g3jcjm 199 18 related relate VBN cord-265139-x7g3jcjm 199 19 IR IR NNP cord-265139-x7g3jcjm 199 20 , , , cord-265139-x7g3jcjm 199 21 they -PRON- PRP cord-265139-x7g3jcjm 199 22 highlight highlight VBP cord-265139-x7g3jcjm 199 23 this this DT cord-265139-x7g3jcjm 199 24 matter matter NN cord-265139-x7g3jcjm 199 25 for for IN cord-265139-x7g3jcjm 199 26 further further JJ cord-265139-x7g3jcjm 199 27 elucidation elucidation NN cord-265139-x7g3jcjm 199 28 . . . cord-265139-x7g3jcjm 200 1 Chronic chronic JJ cord-265139-x7g3jcjm 200 2 low low JJ cord-265139-x7g3jcjm 200 3 - - HYPH cord-265139-x7g3jcjm 200 4 grade grade NN cord-265139-x7g3jcjm 200 5 inflammation inflammation NN cord-265139-x7g3jcjm 200 6 is be VBZ cord-265139-x7g3jcjm 200 7 now now RB cord-265139-x7g3jcjm 200 8 recognized recognize VBN cord-265139-x7g3jcjm 200 9 as as IN cord-265139-x7g3jcjm 200 10 a a DT cord-265139-x7g3jcjm 200 11 hallmark hallmark NN cord-265139-x7g3jcjm 200 12 of of IN cord-265139-x7g3jcjm 200 13 obesity obesity NN cord-265139-x7g3jcjm 200 14 and and CC cord-265139-x7g3jcjm 200 15 a a DT cord-265139-x7g3jcjm 200 16 key key JJ cord-265139-x7g3jcjm 200 17 risk risk NN cord-265139-x7g3jcjm 200 18 factor factor NN cord-265139-x7g3jcjm 200 19 for for IN cord-265139-x7g3jcjm 200 20 IR IR NNP cord-265139-x7g3jcjm 200 21 and and CC cord-265139-x7g3jcjm 200 22 the the DT cord-265139-x7g3jcjm 200 23 development development NN cord-265139-x7g3jcjm 200 24 of of IN cord-265139-x7g3jcjm 200 25 T2DM T2DM NNP cord-265139-x7g3jcjm 200 26 [ [ -LRB- cord-265139-x7g3jcjm 200 27 88 88 CD cord-265139-x7g3jcjm 200 28 , , , cord-265139-x7g3jcjm 200 29 97 97 CD cord-265139-x7g3jcjm 200 30 ] ] -RRB- cord-265139-x7g3jcjm 200 31 . . . cord-265139-x7g3jcjm 201 1 Excess excess JJ cord-265139-x7g3jcjm 201 2 adiposity adiposity NN cord-265139-x7g3jcjm 201 3 typically typically RB cord-265139-x7g3jcjm 201 4 induces induce VBZ cord-265139-x7g3jcjm 201 5 the the DT cord-265139-x7g3jcjm 201 6 recruitment recruitment NN cord-265139-x7g3jcjm 201 7 of of IN cord-265139-x7g3jcjm 201 8 immune immune JJ cord-265139-x7g3jcjm 201 9 cells cell NNS cord-265139-x7g3jcjm 201 10 into into IN cord-265139-x7g3jcjm 201 11 fat fat JJ cord-265139-x7g3jcjm 201 12 depots depot NNS cord-265139-x7g3jcjm 201 13 . . . cord-265139-x7g3jcjm 202 1 These these DT cord-265139-x7g3jcjm 202 2 immune immune JJ cord-265139-x7g3jcjm 202 3 cells cell NNS cord-265139-x7g3jcjm 202 4 , , , cord-265139-x7g3jcjm 202 5 mainly mainly RB cord-265139-x7g3jcjm 202 6 macrophages macrophage NNS cord-265139-x7g3jcjm 202 7 , , , cord-265139-x7g3jcjm 202 8 release release VB cord-265139-x7g3jcjm 202 9 proinflammatory proinflammatory JJ cord-265139-x7g3jcjm 202 10 cytokines cytokine NNS cord-265139-x7g3jcjm 202 11 / / SYM cord-265139-x7g3jcjm 202 12 chemokines chemokine NNS cord-265139-x7g3jcjm 202 13 that that WDT cord-265139-x7g3jcjm 202 14 can can MD cord-265139-x7g3jcjm 202 15 act act VB cord-265139-x7g3jcjm 202 16 locally locally RB cord-265139-x7g3jcjm 202 17 but but CC cord-265139-x7g3jcjm 202 18 also also RB cord-265139-x7g3jcjm 202 19 systemically systemically RB cord-265139-x7g3jcjm 202 20 after after IN cord-265139-x7g3jcjm 202 21 being be VBG cord-265139-x7g3jcjm 202 22 released release VBN cord-265139-x7g3jcjm 202 23 into into IN cord-265139-x7g3jcjm 202 24 the the DT cord-265139-x7g3jcjm 202 25 circulation circulation NN cord-265139-x7g3jcjm 202 26 , , , cord-265139-x7g3jcjm 202 27 therefore therefore RB cord-265139-x7g3jcjm 202 28 activating activate VBG cord-265139-x7g3jcjm 202 29 chronic chronic JJ cord-265139-x7g3jcjm 202 30 inflammation inflammation NN cord-265139-x7g3jcjm 202 31 which which WDT cord-265139-x7g3jcjm 202 32 contributes contribute VBZ cord-265139-x7g3jcjm 202 33 to to IN cord-265139-x7g3jcjm 202 34 the the DT cord-265139-x7g3jcjm 202 35 development development NN cord-265139-x7g3jcjm 202 36 of of IN cord-265139-x7g3jcjm 202 37 obesity obesity NN cord-265139-x7g3jcjm 202 38 and and CC cord-265139-x7g3jcjm 202 39 associated associated JJ cord-265139-x7g3jcjm 202 40 metabolic metabolic JJ cord-265139-x7g3jcjm 202 41 disorders disorder NNS cord-265139-x7g3jcjm 202 42 [ [ -LRB- cord-265139-x7g3jcjm 202 43 98 98 CD cord-265139-x7g3jcjm 202 44 ] ] -RRB- cord-265139-x7g3jcjm 202 45 . . . cord-265139-x7g3jcjm 203 1 Thus thus RB cord-265139-x7g3jcjm 203 2 , , , cord-265139-x7g3jcjm 203 3 better better RB cord-265139-x7g3jcjm 203 4 exploring explore VBG cord-265139-x7g3jcjm 203 5 white white JJ cord-265139-x7g3jcjm 203 6 adipose adipose JJ cord-265139-x7g3jcjm 203 7 tissue tissue NN cord-265139-x7g3jcjm 203 8 inflammation inflammation NN cord-265139-x7g3jcjm 203 9 mechanisms mechanism NNS cord-265139-x7g3jcjm 203 10 and and CC cord-265139-x7g3jcjm 203 11 pinpointing pinpoint VBG cord-265139-x7g3jcjm 203 12 the the DT cord-265139-x7g3jcjm 203 13 immunological immunological JJ cord-265139-x7g3jcjm 203 14 events event NNS cord-265139-x7g3jcjm 203 15 occurring occur VBG cord-265139-x7g3jcjm 203 16 in in IN cord-265139-x7g3jcjm 203 17 this this DT cord-265139-x7g3jcjm 203 18 tissue tissue NN cord-265139-x7g3jcjm 203 19 will will MD cord-265139-x7g3jcjm 203 20 provide provide VB cord-265139-x7g3jcjm 203 21 insights insight NNS cord-265139-x7g3jcjm 203 22 into into IN cord-265139-x7g3jcjm 203 23 the the DT cord-265139-x7g3jcjm 203 24 pathophysiological pathophysiological JJ cord-265139-x7g3jcjm 203 25 role role NN cord-265139-x7g3jcjm 203 26 of of IN cord-265139-x7g3jcjm 203 27 inflammation inflammation NN cord-265139-x7g3jcjm 203 28 in in IN cord-265139-x7g3jcjm 203 29 obesity obesity NN cord-265139-x7g3jcjm 203 30 and and CC cord-265139-x7g3jcjm 203 31 help help NN cord-265139-x7g3jcjm 203 32 to to TO cord-265139-x7g3jcjm 203 33 manage manage VB cord-265139-x7g3jcjm 203 34 obesity obesity NN cord-265139-x7g3jcjm 203 35 related relate VBN cord-265139-x7g3jcjm 203 36 diseases disease NNS cord-265139-x7g3jcjm 203 37 . . . cord-265139-x7g3jcjm 204 1 Although although IN cord-265139-x7g3jcjm 204 2 there there EX cord-265139-x7g3jcjm 204 3 has have VBZ cord-265139-x7g3jcjm 204 4 been be VBN cord-265139-x7g3jcjm 204 5 some some DT cord-265139-x7g3jcjm 204 6 progress progress NN cord-265139-x7g3jcjm 204 7 in in IN cord-265139-x7g3jcjm 204 8 the the DT cord-265139-x7g3jcjm 204 9 role role NN cord-265139-x7g3jcjm 204 10 of of IN cord-265139-x7g3jcjm 204 11 ncRNAs ncRNAs NNP cord-265139-x7g3jcjm 204 12 in in IN cord-265139-x7g3jcjm 204 13 adipogenesis adipogenesis NNP cord-265139-x7g3jcjm 204 14 , , , cord-265139-x7g3jcjm 204 15 the the DT cord-265139-x7g3jcjm 204 16 significance significance NN cord-265139-x7g3jcjm 204 17 of of IN cord-265139-x7g3jcjm 204 18 these these DT cord-265139-x7g3jcjm 204 19 RNAs rna NNS cord-265139-x7g3jcjm 204 20 in in IN cord-265139-x7g3jcjm 204 21 adipose adipose JJ cord-265139-x7g3jcjm 204 22 inflammation inflammation NN cord-265139-x7g3jcjm 204 23 remains remain VBZ cord-265139-x7g3jcjm 204 24 elusive elusive JJ cord-265139-x7g3jcjm 204 25 . . . cord-265139-x7g3jcjm 205 1 The the DT cord-265139-x7g3jcjm 205 2 implication implication NN cord-265139-x7g3jcjm 205 3 of of IN cord-265139-x7g3jcjm 205 4 some some DT cord-265139-x7g3jcjm 205 5 ncRNAs ncrna NNS cord-265139-x7g3jcjm 205 6 in in IN cord-265139-x7g3jcjm 205 7 the the DT cord-265139-x7g3jcjm 205 8 regulation regulation NN cord-265139-x7g3jcjm 205 9 of of IN cord-265139-x7g3jcjm 205 10 obesity obesity NN cord-265139-x7g3jcjm 205 11 - - HYPH cord-265139-x7g3jcjm 205 12 associated associate VBN cord-265139-x7g3jcjm 205 13 inflammation inflammation NN cord-265139-x7g3jcjm 205 14 has have VBZ cord-265139-x7g3jcjm 205 15 been be VBN cord-265139-x7g3jcjm 205 16 suggested suggest VBN cord-265139-x7g3jcjm 205 17 previously previously RB cord-265139-x7g3jcjm 205 18 . . . cord-265139-x7g3jcjm 206 1 As as IN cord-265139-x7g3jcjm 206 2 an an DT cord-265139-x7g3jcjm 206 3 example example NN cord-265139-x7g3jcjm 206 4 , , , cord-265139-x7g3jcjm 206 5 Stapleton Stapleton NNP cord-265139-x7g3jcjm 206 6 et et NNP cord-265139-x7g3jcjm 206 7 al al NNP cord-265139-x7g3jcjm 206 8 . . NNP cord-265139-x7g3jcjm 206 9 identified identify VBD cord-265139-x7g3jcjm 206 10 a a DT cord-265139-x7g3jcjm 206 11 novel novel NN cord-265139-x7g3jcjm 206 12 lncRNA lncrna NN cord-265139-x7g3jcjm 206 13 named name VBN cord-265139-x7g3jcjm 206 14 macrophage macrophage NN cord-265139-x7g3jcjm 206 15 inflammation inflammation NN cord-265139-x7g3jcjm 206 16 - - HYPH cord-265139-x7g3jcjm 206 17 suppressing suppress VBG cord-265139-x7g3jcjm 206 18 transcript transcript NN cord-265139-x7g3jcjm 206 19 ( ( -LRB- cord-265139-x7g3jcjm 206 20 MIST MIST NNP cord-265139-x7g3jcjm 206 21 ) ) -RRB- cord-265139-x7g3jcjm 206 22 which which WDT cord-265139-x7g3jcjm 206 23 was be VBD cord-265139-x7g3jcjm 206 24 downregulated downregulate VBN cord-265139-x7g3jcjm 206 25 in in IN cord-265139-x7g3jcjm 206 26 both both DT cord-265139-x7g3jcjm 206 27 peritoneal peritoneal JJ cord-265139-x7g3jcjm 206 28 macrophages macrophage NNS cord-265139-x7g3jcjm 206 29 and and CC cord-265139-x7g3jcjm 206 30 adipose adipose JJ cord-265139-x7g3jcjm 206 31 tissue tissue NN cord-265139-x7g3jcjm 206 32 macrophages macrophage NNS cord-265139-x7g3jcjm 206 33 from from IN cord-265139-x7g3jcjm 206 34 high high JJ cord-265139-x7g3jcjm 206 35 - - HYPH cord-265139-x7g3jcjm 206 36 fat fat NN cord-265139-x7g3jcjm 206 37 diet diet NN cord-265139-x7g3jcjm 206 38 - - HYPH cord-265139-x7g3jcjm 206 39 fed feed VBN cord-265139-x7g3jcjm 206 40 obese obese JJ cord-265139-x7g3jcjm 206 41 mice mouse NNS cord-265139-x7g3jcjm 206 42 [ [ -LRB- cord-265139-x7g3jcjm 206 43 99 99 CD cord-265139-x7g3jcjm 206 44 ] ] -RRB- cord-265139-x7g3jcjm 206 45 . . . cord-265139-x7g3jcjm 207 1 Moreover moreover RB cord-265139-x7g3jcjm 207 2 , , , cord-265139-x7g3jcjm 207 3 human human JJ cord-265139-x7g3jcjm 207 4 ortholog ortholog NN cord-265139-x7g3jcjm 207 5 of of IN cord-265139-x7g3jcjm 207 6 MIST MIST NNP cord-265139-x7g3jcjm 207 7 was be VBD cord-265139-x7g3jcjm 207 8 found find VBN cord-265139-x7g3jcjm 207 9 to to TO cord-265139-x7g3jcjm 207 10 be be VB cord-265139-x7g3jcjm 207 11 expressed express VBN cord-265139-x7g3jcjm 207 12 in in IN cord-265139-x7g3jcjm 207 13 human human JJ cord-265139-x7g3jcjm 207 14 adipose adipose JJ cord-265139-x7g3jcjm 207 15 tissue tissue NN cord-265139-x7g3jcjm 207 16 macrophages macrophage NNS cord-265139-x7g3jcjm 207 17 and and CC cord-265139-x7g3jcjm 207 18 inversely inversely RB cord-265139-x7g3jcjm 207 19 correlated correlate VBD cord-265139-x7g3jcjm 207 20 with with IN cord-265139-x7g3jcjm 207 21 obesity obesity NN cord-265139-x7g3jcjm 207 22 and and CC cord-265139-x7g3jcjm 207 23 IR IR NNP cord-265139-x7g3jcjm 207 24 . . . cord-265139-x7g3jcjm 208 1 Recently recently RB cord-265139-x7g3jcjm 208 2 , , , cord-265139-x7g3jcjm 208 3 an an DT cord-265139-x7g3jcjm 208 4 elegant elegant JJ cord-265139-x7g3jcjm 208 5 study study NN cord-265139-x7g3jcjm 208 6 by by IN cord-265139-x7g3jcjm 208 7 Arcinas Arcinas NNP cord-265139-x7g3jcjm 208 8 and and CC cord-265139-x7g3jcjm 208 9 colleagues colleague NNS cord-265139-x7g3jcjm 208 10 demonstrated demonstrate VBD cord-265139-x7g3jcjm 208 11 a a DT cord-265139-x7g3jcjm 208 12 general general JJ cord-265139-x7g3jcjm 208 13 decrease decrease NN cord-265139-x7g3jcjm 208 14 of of IN cord-265139-x7g3jcjm 208 15 circRNA circrna NN cord-265139-x7g3jcjm 208 16 transcripts transcript NNS cord-265139-x7g3jcjm 208 17 in in IN cord-265139-x7g3jcjm 208 18 adipose adipose JJ cord-265139-x7g3jcjm 208 19 tissue tissue NN cord-265139-x7g3jcjm 208 20 of of IN cord-265139-x7g3jcjm 208 21 HFD HFD NNP cord-265139-x7g3jcjm 208 22 mice mouse NNS cord-265139-x7g3jcjm 208 23 , , , cord-265139-x7g3jcjm 208 24 suggesting suggest VBG cord-265139-x7g3jcjm 208 25 that that IN cord-265139-x7g3jcjm 208 26 inflammation inflammation NN cord-265139-x7g3jcjm 208 27 may may MD cord-265139-x7g3jcjm 208 28 affect affect VB cord-265139-x7g3jcjm 208 29 circRNA circRNA NNP cord-265139-x7g3jcjm 208 30 biogenesis biogenesis NN cord-265139-x7g3jcjm 208 31 [ [ -LRB- cord-265139-x7g3jcjm 208 32 80 80 CD cord-265139-x7g3jcjm 208 33 ] ] -RRB- cord-265139-x7g3jcjm 208 34 . . . cord-265139-x7g3jcjm 209 1 This this DT cord-265139-x7g3jcjm 209 2 assumption assumption NN cord-265139-x7g3jcjm 209 3 was be VBD cord-265139-x7g3jcjm 209 4 based base VBN cord-265139-x7g3jcjm 209 5 on on IN cord-265139-x7g3jcjm 209 6 the the DT cord-265139-x7g3jcjm 209 7 observation observation NN cord-265139-x7g3jcjm 209 8 that that IN cord-265139-x7g3jcjm 209 9 treatment treatment NN cord-265139-x7g3jcjm 209 10 of of IN cord-265139-x7g3jcjm 209 11 differentiated differentiated JJ cord-265139-x7g3jcjm 209 12 primary primary JJ cord-265139-x7g3jcjm 209 13 mouse mouse NN cord-265139-x7g3jcjm 209 14 subcutaneous subcutaneous JJ cord-265139-x7g3jcjm 209 15 adipocytes adipocyte NNS cord-265139-x7g3jcjm 209 16 with with IN cord-265139-x7g3jcjm 209 17 soluble soluble JJ cord-265139-x7g3jcjm 209 18 tumor tumor NN cord-265139-x7g3jcjm 209 19 necrosis necrosis NN cord-265139-x7g3jcjm 209 20 factor factor NN cord-265139-x7g3jcjm 209 21 ( ( -LRB- cord-265139-x7g3jcjm 209 22 TNF)-α TNF)-α NNP cord-265139-x7g3jcjm 209 23 led lead VBD cord-265139-x7g3jcjm 209 24 to to IN cord-265139-x7g3jcjm 209 25 significant significant JJ cord-265139-x7g3jcjm 209 26 reduction reduction NN cord-265139-x7g3jcjm 209 27 in in IN cord-265139-x7g3jcjm 209 28 circRNAs circrnas JJ cord-265139-x7g3jcjm 209 29 expression expression NN cord-265139-x7g3jcjm 209 30 [ [ -LRB- cord-265139-x7g3jcjm 209 31 80 80 CD cord-265139-x7g3jcjm 209 32 ] ] -RRB- cord-265139-x7g3jcjm 209 33 . . . cord-265139-x7g3jcjm 210 1 In in IN cord-265139-x7g3jcjm 210 2 another another DT cord-265139-x7g3jcjm 210 3 study study NN cord-265139-x7g3jcjm 210 4 , , , cord-265139-x7g3jcjm 210 5 it -PRON- PRP cord-265139-x7g3jcjm 210 6 was be VBD cord-265139-x7g3jcjm 210 7 observed observe VBN cord-265139-x7g3jcjm 210 8 that that IN cord-265139-x7g3jcjm 210 9 circARF3 circarf3 NN cord-265139-x7g3jcjm 210 10 ( ( -LRB- cord-265139-x7g3jcjm 210 11 ADP ADP NNP cord-265139-x7g3jcjm 210 12 - - HYPH cord-265139-x7g3jcjm 210 13 ribosylation ribosylation NN cord-265139-x7g3jcjm 210 14 factor factor NN cord-265139-x7g3jcjm 210 15 3 3 CD cord-265139-x7g3jcjm 210 16 ) ) -RRB- cord-265139-x7g3jcjm 210 17 functions function VBZ cord-265139-x7g3jcjm 210 18 as as IN cord-265139-x7g3jcjm 210 19 an an DT cord-265139-x7g3jcjm 210 20 endogenous endogenous JJ cord-265139-x7g3jcjm 210 21 miR-103 mir-103 NN cord-265139-x7g3jcjm 210 22 sponge sponge NN cord-265139-x7g3jcjm 210 23 to to TO cord-265139-x7g3jcjm 210 24 inhibit inhibit VB cord-265139-x7g3jcjm 210 25 miR-103 mir-103 NN cord-265139-x7g3jcjm 210 26 activity activity NN cord-265139-x7g3jcjm 210 27 , , , cord-265139-x7g3jcjm 210 28 resulting result VBG cord-265139-x7g3jcjm 210 29 in in IN cord-265139-x7g3jcjm 210 30 an an DT cord-265139-x7g3jcjm 210 31 increase increase NN cord-265139-x7g3jcjm 210 32 of of IN cord-265139-x7g3jcjm 210 33 TNF TNF NNP cord-265139-x7g3jcjm 210 34 receptor receptor NN cord-265139-x7g3jcjm 210 35 - - HYPH cord-265139-x7g3jcjm 210 36 associated associate VBN cord-265139-x7g3jcjm 210 37 factor factor NN cord-265139-x7g3jcjm 210 38 3 3 CD cord-265139-x7g3jcjm 210 39 ( ( -LRB- cord-265139-x7g3jcjm 210 40 TRAF3 traf3 NN cord-265139-x7g3jcjm 210 41 ) ) -RRB- cord-265139-x7g3jcjm 210 42 expression expression NN cord-265139-x7g3jcjm 210 43 and and CC cord-265139-x7g3jcjm 210 44 accordingly accordingly RB cord-265139-x7g3jcjm 210 45 alleviates alleviate VBZ cord-265139-x7g3jcjm 210 46 inflammation inflammation NN cord-265139-x7g3jcjm 210 47 in in IN cord-265139-x7g3jcjm 210 48 mouse mouse NN cord-265139-x7g3jcjm 210 49 adipose adipose JJ cord-265139-x7g3jcjm 210 50 tissue tissue NN cord-265139-x7g3jcjm 210 51 [ [ -LRB- cord-265139-x7g3jcjm 210 52 100 100 CD cord-265139-x7g3jcjm 210 53 ] ] -RRB- cord-265139-x7g3jcjm 210 54 . . . cord-265139-x7g3jcjm 211 1 Subsequent subsequent JJ cord-265139-x7g3jcjm 211 2 experiments experiment NNS cord-265139-x7g3jcjm 211 3 provided provide VBD cord-265139-x7g3jcjm 211 4 more more RBR cord-265139-x7g3jcjm 211 5 consistent consistent JJ cord-265139-x7g3jcjm 211 6 support support NN cord-265139-x7g3jcjm 211 7 for for IN cord-265139-x7g3jcjm 211 8 the the DT cord-265139-x7g3jcjm 211 9 notion notion NN cord-265139-x7g3jcjm 211 10 that that IN cord-265139-x7g3jcjm 211 11 circARF3 circarf3 NN cord-265139-x7g3jcjm 211 12 is be VBZ cord-265139-x7g3jcjm 211 13 involved involve VBN cord-265139-x7g3jcjm 211 14 in in IN cord-265139-x7g3jcjm 211 15 inflammation inflammation NN cord-265139-x7g3jcjm 211 16 as as IN cord-265139-x7g3jcjm 211 17 adipose adipose JJ cord-265139-x7g3jcjm 211 18 inflammation inflammation NN cord-265139-x7g3jcjm 211 19 was be VBD cord-265139-x7g3jcjm 211 20 improved improve VBN cord-265139-x7g3jcjm 211 21 because because IN cord-265139-x7g3jcjm 211 22 TRAF3 TRAF3 NNP cord-265139-x7g3jcjm 211 23 blocked block VBD cord-265139-x7g3jcjm 211 24 the the DT cord-265139-x7g3jcjm 211 25 nuclear nuclear JJ cord-265139-x7g3jcjm 211 26 factor factor NN cord-265139-x7g3jcjm 211 27 κB κB . cord-265139-x7g3jcjm 212 1 ( ( -LRB- cord-265139-x7g3jcjm 212 2 NF nf NN cord-265139-x7g3jcjm 212 3 - - HYPH cord-265139-x7g3jcjm 212 4 κB)-signaling κb)-signaling NN cord-265139-x7g3jcjm 212 5 pathway pathway NN cord-265139-x7g3jcjm 212 6 , , , cord-265139-x7g3jcjm 212 7 promoted promote VBD cord-265139-x7g3jcjm 212 8 mitophagy mitophagy NN cord-265139-x7g3jcjm 212 9 , , , cord-265139-x7g3jcjm 212 10 and and CC cord-265139-x7g3jcjm 212 11 suppressed suppress VBD cord-265139-x7g3jcjm 212 12 NOD nod NN cord-265139-x7g3jcjm 212 13 - - HYPH cord-265139-x7g3jcjm 212 14 like like JJ cord-265139-x7g3jcjm 212 15 receptor receptor NN cord-265139-x7g3jcjm 212 16 family family NN cord-265139-x7g3jcjm 212 17 , , , cord-265139-x7g3jcjm 212 18 pyrin pyrin NNP cord-265139-x7g3jcjm 212 19 domain domain NN cord-265139-x7g3jcjm 212 20 - - HYPH cord-265139-x7g3jcjm 212 21 containing contain VBG cord-265139-x7g3jcjm 212 22 protein protein NN cord-265139-x7g3jcjm 212 23 3 3 CD cord-265139-x7g3jcjm 212 24 ( ( -LRB- cord-265139-x7g3jcjm 212 25 NLRP3 nlrp3 NN cord-265139-x7g3jcjm 212 26 ) ) -RRB- cord-265139-x7g3jcjm 213 1 inflammasome inflammasome NNP cord-265139-x7g3jcjm 213 2 activation activation NN cord-265139-x7g3jcjm 213 3 and and CC cord-265139-x7g3jcjm 213 4 inflammatory inflammatory JJ cord-265139-x7g3jcjm 213 5 cytokine cytokine NN cord-265139-x7g3jcjm 213 6 release release NN cord-265139-x7g3jcjm 213 7 [ [ -LRB- cord-265139-x7g3jcjm 213 8 100 100 CD cord-265139-x7g3jcjm 213 9 ] ] -RRB- cord-265139-x7g3jcjm 213 10 . . . cord-265139-x7g3jcjm 214 1 On on IN cord-265139-x7g3jcjm 214 2 the the DT cord-265139-x7g3jcjm 214 3 contrary contrary NN cord-265139-x7g3jcjm 214 4 , , , cord-265139-x7g3jcjm 214 5 another another DT cord-265139-x7g3jcjm 214 6 study study NN cord-265139-x7g3jcjm 214 7 reported report VBD cord-265139-x7g3jcjm 214 8 that that IN cord-265139-x7g3jcjm 214 9 myeloid myeloid JJ cord-265139-x7g3jcjm 214 10 cell cell NN cord-265139-x7g3jcjm 214 11 TRAF3 traf3 NN cord-265139-x7g3jcjm 214 12 promotes promote VBZ cord-265139-x7g3jcjm 214 13 metabolic metabolic JJ cord-265139-x7g3jcjm 214 14 inflammation inflammation NN cord-265139-x7g3jcjm 214 15 , , , cord-265139-x7g3jcjm 214 16 insulin insulin NN cord-265139-x7g3jcjm 214 17 resistance resistance NN cord-265139-x7g3jcjm 214 18 , , , cord-265139-x7g3jcjm 214 19 and and CC cord-265139-x7g3jcjm 214 20 hepatic hepatic JJ cord-265139-x7g3jcjm 214 21 steatosis steatosis NN cord-265139-x7g3jcjm 214 22 in in IN cord-265139-x7g3jcjm 214 23 obesity obesity NN cord-265139-x7g3jcjm 214 24 [ [ -LRB- cord-265139-x7g3jcjm 214 25 101 101 CD cord-265139-x7g3jcjm 214 26 ] ] -RRB- cord-265139-x7g3jcjm 214 27 . . . cord-265139-x7g3jcjm 215 1 These these DT cord-265139-x7g3jcjm 215 2 authors author NNS cord-265139-x7g3jcjm 215 3 further further RB cord-265139-x7g3jcjm 215 4 showed show VBD cord-265139-x7g3jcjm 215 5 that that IN cord-265139-x7g3jcjm 215 6 myeloid myeloid NN cord-265139-x7g3jcjm 215 7 TRAF3 traf3 NN cord-265139-x7g3jcjm 215 8 may may MD cord-265139-x7g3jcjm 215 9 have have VB cord-265139-x7g3jcjm 215 10 anti anti JJ cord-265139-x7g3jcjm 215 11 - - JJ cord-265139-x7g3jcjm 215 12 inflammatory inflammatory JJ cord-265139-x7g3jcjm 215 13 and and CC cord-265139-x7g3jcjm 215 14 proinflammatory proinflammatory JJ cord-265139-x7g3jcjm 215 15 activities activity NNS cord-265139-x7g3jcjm 215 16 in in IN cord-265139-x7g3jcjm 215 17 lean lean JJ cord-265139-x7g3jcjm 215 18 and and CC cord-265139-x7g3jcjm 215 19 obese obese JJ cord-265139-x7g3jcjm 215 20 mice mouse NNS cord-265139-x7g3jcjm 215 21 respectively respectively RB cord-265139-x7g3jcjm 215 22 , , , cord-265139-x7g3jcjm 215 23 suggesting suggest VBG cord-265139-x7g3jcjm 215 24 that that IN cord-265139-x7g3jcjm 215 25 , , , cord-265139-x7g3jcjm 215 26 in in IN cord-265139-x7g3jcjm 215 27 obesity obesity NN cord-265139-x7g3jcjm 215 28 progression progression NN cord-265139-x7g3jcjm 215 29 , , , cord-265139-x7g3jcjm 215 30 myeloid myeloid NN cord-265139-x7g3jcjm 215 31 TRAF3 traf3 NN cord-265139-x7g3jcjm 215 32 functionally functionally RB cord-265139-x7g3jcjm 215 33 switches switch VBZ cord-265139-x7g3jcjm 215 34 its -PRON- PRP$ cord-265139-x7g3jcjm 215 35 activity activity NN cord-265139-x7g3jcjm 215 36 from from IN cord-265139-x7g3jcjm 215 37 anti anti JJ cord-265139-x7g3jcjm 215 38 - - JJ cord-265139-x7g3jcjm 215 39 inflammatory inflammatory JJ cord-265139-x7g3jcjm 215 40 to to IN cord-265139-x7g3jcjm 215 41 proinflammatory proinflammatory JJ cord-265139-x7g3jcjm 215 42 modes mode NNS cord-265139-x7g3jcjm 215 43 . . . cord-265139-x7g3jcjm 216 1 Obesity obesity NN cord-265139-x7g3jcjm 216 2 and and CC cord-265139-x7g3jcjm 216 3 inflammation inflammation NN cord-265139-x7g3jcjm 216 4 have have VBP cord-265139-x7g3jcjm 216 5 been be VBN cord-265139-x7g3jcjm 216 6 associated associate VBN cord-265139-x7g3jcjm 216 7 with with IN cord-265139-x7g3jcjm 216 8 several several JJ cord-265139-x7g3jcjm 216 9 complications complication NNS cord-265139-x7g3jcjm 216 10 including include VBG cord-265139-x7g3jcjm 216 11 T2DM T2DM NNP cord-265139-x7g3jcjm 216 12 , , , cord-265139-x7g3jcjm 216 13 CVD CVD NNP cord-265139-x7g3jcjm 216 14 , , , cord-265139-x7g3jcjm 216 15 hypertension hypertension NN cord-265139-x7g3jcjm 216 16 , , , cord-265139-x7g3jcjm 216 17 and and CC cord-265139-x7g3jcjm 216 18 stroke stroke NN cord-265139-x7g3jcjm 216 19 [ [ -LRB- cord-265139-x7g3jcjm 216 20 102 102 CD cord-265139-x7g3jcjm 216 21 ] ] -RRB- cord-265139-x7g3jcjm 216 22 . . . cord-265139-x7g3jcjm 217 1 In in IN cord-265139-x7g3jcjm 217 2 this this DT cord-265139-x7g3jcjm 217 3 perspective perspective NN cord-265139-x7g3jcjm 217 4 , , , cord-265139-x7g3jcjm 217 5 Fang Fang NNP cord-265139-x7g3jcjm 217 6 et et FW cord-265139-x7g3jcjm 217 7 al al NNP cord-265139-x7g3jcjm 217 8 . . . cord-265139-x7g3jcjm 218 1 [ [ -LRB- cord-265139-x7g3jcjm 218 2 103 103 CD cord-265139-x7g3jcjm 218 3 ] ] -RRB- cord-265139-x7g3jcjm 218 4 indicated indicate VBD cord-265139-x7g3jcjm 218 5 that that IN cord-265139-x7g3jcjm 218 6 the the DT cord-265139-x7g3jcjm 218 7 expression expression NN cord-265139-x7g3jcjm 218 8 of of IN cord-265139-x7g3jcjm 218 9 circANKRD36 circankrd36 NN cord-265139-x7g3jcjm 218 10 was be VBD cord-265139-x7g3jcjm 218 11 upregulated upregulate VBN cord-265139-x7g3jcjm 218 12 in in IN cord-265139-x7g3jcjm 218 13 peripheral peripheral JJ cord-265139-x7g3jcjm 218 14 blood blood NN cord-265139-x7g3jcjm 218 15 leucocytes leucocyte NNS cord-265139-x7g3jcjm 218 16 and and CC cord-265139-x7g3jcjm 218 17 correlated correlate VBN cord-265139-x7g3jcjm 218 18 with with IN cord-265139-x7g3jcjm 218 19 chronic chronic JJ cord-265139-x7g3jcjm 218 20 inflammation inflammation NN cord-265139-x7g3jcjm 218 21 in in IN cord-265139-x7g3jcjm 218 22 T2DM T2DM NNP cord-265139-x7g3jcjm 218 23 , , , cord-265139-x7g3jcjm 218 24 suggesting suggest VBG cord-265139-x7g3jcjm 218 25 that that IN cord-265139-x7g3jcjm 218 26 circANKRD36 circankrd36 NN cord-265139-x7g3jcjm 218 27 can can MD cord-265139-x7g3jcjm 218 28 be be VB cord-265139-x7g3jcjm 218 29 used use VBN cord-265139-x7g3jcjm 218 30 as as IN cord-265139-x7g3jcjm 218 31 a a DT cord-265139-x7g3jcjm 218 32 potential potential JJ cord-265139-x7g3jcjm 218 33 biomarker biomarker NN cord-265139-x7g3jcjm 218 34 for for IN cord-265139-x7g3jcjm 218 35 screening screen VBG cord-265139-x7g3jcjm 218 36 chronic chronic JJ cord-265139-x7g3jcjm 218 37 inflammation inflammation NN cord-265139-x7g3jcjm 218 38 in in IN cord-265139-x7g3jcjm 218 39 patients patient NNS cord-265139-x7g3jcjm 218 40 with with IN cord-265139-x7g3jcjm 218 41 T2DM T2DM NNP cord-265139-x7g3jcjm 218 42 . . . cord-265139-x7g3jcjm 219 1 As as IN cord-265139-x7g3jcjm 219 2 it -PRON- PRP cord-265139-x7g3jcjm 219 3 is be VBZ cord-265139-x7g3jcjm 219 4 estimated estimate VBN cord-265139-x7g3jcjm 219 5 that that IN cord-265139-x7g3jcjm 219 6 a a DT cord-265139-x7g3jcjm 219 7 total total NN cord-265139-x7g3jcjm 219 8 of of IN cord-265139-x7g3jcjm 219 9 80 80 CD cord-265139-x7g3jcjm 219 10 % % NN cord-265139-x7g3jcjm 219 11 of of IN cord-265139-x7g3jcjm 219 12 individuals individual NNS cord-265139-x7g3jcjm 219 13 with with IN cord-265139-x7g3jcjm 219 14 type type NN cord-265139-x7g3jcjm 219 15 2 2 CD cord-265139-x7g3jcjm 219 16 diabetes diabete NNS cord-265139-x7g3jcjm 219 17 are be VBP cord-265139-x7g3jcjm 219 18 obese obese JJ cord-265139-x7g3jcjm 219 19 [ [ -LRB- cord-265139-x7g3jcjm 219 20 104 104 CD cord-265139-x7g3jcjm 219 21 ] ] -RRB- cord-265139-x7g3jcjm 219 22 , , , cord-265139-x7g3jcjm 219 23 it -PRON- PRP cord-265139-x7g3jcjm 219 24 will will MD cord-265139-x7g3jcjm 219 25 be be VB cord-265139-x7g3jcjm 219 26 interesting interesting JJ cord-265139-x7g3jcjm 219 27 to to TO cord-265139-x7g3jcjm 219 28 evaluate evaluate VB cord-265139-x7g3jcjm 219 29 the the DT cord-265139-x7g3jcjm 219 30 role role NN cord-265139-x7g3jcjm 219 31 of of IN cord-265139-x7g3jcjm 219 32 circANKRD36 circankrd36 NN cord-265139-x7g3jcjm 219 33 in in IN cord-265139-x7g3jcjm 219 34 obesity obesity NN cord-265139-x7g3jcjm 219 35 inflammatory inflammatory JJ cord-265139-x7g3jcjm 219 36 context context NN cord-265139-x7g3jcjm 219 37 . . . cord-265139-x7g3jcjm 220 1 Unlike unlike IN cord-265139-x7g3jcjm 220 2 white white JJ cord-265139-x7g3jcjm 220 3 adipocyte adipocyte NN cord-265139-x7g3jcjm 220 4 tissue tissue NN cord-265139-x7g3jcjm 220 5 ( ( -LRB- cord-265139-x7g3jcjm 220 6 WAT WAT NNP cord-265139-x7g3jcjm 220 7 ) ) -RRB- cord-265139-x7g3jcjm 220 8 , , , cord-265139-x7g3jcjm 220 9 which which WDT cord-265139-x7g3jcjm 220 10 primarily primarily RB cord-265139-x7g3jcjm 220 11 stores store VBZ cord-265139-x7g3jcjm 220 12 lipids lipid NNS cord-265139-x7g3jcjm 220 13 , , , cord-265139-x7g3jcjm 220 14 brown brown JJ cord-265139-x7g3jcjm 220 15 adipocyte adipocyte NN cord-265139-x7g3jcjm 220 16 tissue tissue NN cord-265139-x7g3jcjm 220 17 ( ( -LRB- cord-265139-x7g3jcjm 220 18 BAT bat NN cord-265139-x7g3jcjm 220 19 ) ) -RRB- cord-265139-x7g3jcjm 220 20 can can MD cord-265139-x7g3jcjm 220 21 promote promote VB cord-265139-x7g3jcjm 220 22 energy energy NN cord-265139-x7g3jcjm 220 23 metabolism metabolism NN cord-265139-x7g3jcjm 220 24 by by IN cord-265139-x7g3jcjm 220 25 decreasing decrease VBG cord-265139-x7g3jcjm 220 26 adiposity adiposity NN cord-265139-x7g3jcjm 220 27 and and CC cord-265139-x7g3jcjm 220 28 increasing increase VBG cord-265139-x7g3jcjm 220 29 energy energy NN cord-265139-x7g3jcjm 220 30 expenditure expenditure NN cord-265139-x7g3jcjm 220 31 . . . cord-265139-x7g3jcjm 221 1 Loss loss NN cord-265139-x7g3jcjm 221 2 of of IN cord-265139-x7g3jcjm 221 3 BAT bat NN cord-265139-x7g3jcjm 221 4 activity activity NN cord-265139-x7g3jcjm 221 5 may may MD cord-265139-x7g3jcjm 221 6 contribute contribute VB cord-265139-x7g3jcjm 221 7 to to IN cord-265139-x7g3jcjm 221 8 obesity obesity NN cord-265139-x7g3jcjm 221 9 and and CC cord-265139-x7g3jcjm 221 10 development development NN cord-265139-x7g3jcjm 221 11 of of IN cord-265139-x7g3jcjm 221 12 IR IR NNP cord-265139-x7g3jcjm 221 13 . . . cord-265139-x7g3jcjm 222 1 Hence hence RB cord-265139-x7g3jcjm 222 2 , , , cord-265139-x7g3jcjm 222 3 WAT WAT NNP cord-265139-x7g3jcjm 222 4 browning browning NNP cord-265139-x7g3jcjm 222 5 has have VBZ cord-265139-x7g3jcjm 222 6 gained gain VBN cord-265139-x7g3jcjm 222 7 considerable considerable JJ cord-265139-x7g3jcjm 222 8 attention attention NN cord-265139-x7g3jcjm 222 9 for for IN cord-265139-x7g3jcjm 222 10 its -PRON- PRP$ cord-265139-x7g3jcjm 222 11 potential potential NN cord-265139-x7g3jcjm 222 12 to to TO cord-265139-x7g3jcjm 222 13 reverse reverse VB cord-265139-x7g3jcjm 222 14 obesity obesity NN cord-265139-x7g3jcjm 222 15 and and CC cord-265139-x7g3jcjm 222 16 related relate VBN cord-265139-x7g3jcjm 222 17 metabolic metabolic JJ cord-265139-x7g3jcjm 222 18 complications complication NNS cord-265139-x7g3jcjm 222 19 [ [ -LRB- cord-265139-x7g3jcjm 222 20 105 105 CD cord-265139-x7g3jcjm 222 21 ] ] -RRB- cord-265139-x7g3jcjm 222 22 . . . cord-265139-x7g3jcjm 223 1 A a DT cord-265139-x7g3jcjm 223 2 variety variety NN cord-265139-x7g3jcjm 223 3 of of IN cord-265139-x7g3jcjm 223 4 stimuli stimulus NNS cord-265139-x7g3jcjm 223 5 and and CC cord-265139-x7g3jcjm 223 6 factors factor NNS cord-265139-x7g3jcjm 223 7 such such JJ cord-265139-x7g3jcjm 223 8 as as IN cord-265139-x7g3jcjm 223 9 dietary dietary JJ cord-265139-x7g3jcjm 223 10 factors factor NNS cord-265139-x7g3jcjm 223 11 , , , cord-265139-x7g3jcjm 223 12 cold cold JJ cord-265139-x7g3jcjm 223 13 exposure exposure NN cord-265139-x7g3jcjm 223 14 , , , cord-265139-x7g3jcjm 223 15 nuclear nuclear JJ cord-265139-x7g3jcjm 223 16 receptors receptor NNS cord-265139-x7g3jcjm 223 17 and and CC cord-265139-x7g3jcjm 223 18 ligands ligand NNS cord-265139-x7g3jcjm 223 19 , , , cord-265139-x7g3jcjm 223 20 certain certain JJ cord-265139-x7g3jcjm 223 21 drugs drug NNS cord-265139-x7g3jcjm 223 22 , , , cord-265139-x7g3jcjm 223 23 and and CC cord-265139-x7g3jcjm 223 24 some some DT cord-265139-x7g3jcjm 223 25 ncRNAs ncrna NNS cord-265139-x7g3jcjm 223 26 can can MD cord-265139-x7g3jcjm 223 27 induce induce VB cord-265139-x7g3jcjm 223 28 a a DT cord-265139-x7g3jcjm 223 29 phenotypic phenotypic NN cord-265139-x7g3jcjm 223 30 switch switch NN cord-265139-x7g3jcjm 223 31 in in IN cord-265139-x7g3jcjm 223 32 adipose adipose JJ cord-265139-x7g3jcjm 223 33 tissue tissue NN cord-265139-x7g3jcjm 223 34 from from IN cord-265139-x7g3jcjm 223 35 WAT WAT NNP cord-265139-x7g3jcjm 223 36 to to IN cord-265139-x7g3jcjm 223 37 BAT bat NN cord-265139-x7g3jcjm 223 38 and and CC cord-265139-x7g3jcjm 223 39 regulate regulate VB cord-265139-x7g3jcjm 223 40 browning brown VBG cord-265139-x7g3jcjm 223 41 [ [ -LRB- cord-265139-x7g3jcjm 223 42 106 106 CD cord-265139-x7g3jcjm 223 43 ] ] -RRB- cord-265139-x7g3jcjm 223 44 [ [ -LRB- cord-265139-x7g3jcjm 223 45 107 107 CD cord-265139-x7g3jcjm 223 46 ] ] -RRB- cord-265139-x7g3jcjm 223 47 [ [ -LRB- cord-265139-x7g3jcjm 223 48 108 108 CD cord-265139-x7g3jcjm 223 49 ] ] -RRB- cord-265139-x7g3jcjm 223 50 [ [ -LRB- cord-265139-x7g3jcjm 223 51 109 109 CD cord-265139-x7g3jcjm 223 52 ] ] -RRB- cord-265139-x7g3jcjm 223 53 . . . cord-265139-x7g3jcjm 224 1 Although although IN cord-265139-x7g3jcjm 224 2 significant significant JJ cord-265139-x7g3jcjm 224 3 progress progress NN cord-265139-x7g3jcjm 224 4 has have VBZ cord-265139-x7g3jcjm 224 5 been be VBN cord-265139-x7g3jcjm 224 6 made make VBN cord-265139-x7g3jcjm 224 7 in in IN cord-265139-x7g3jcjm 224 8 understanding understand VBG cord-265139-x7g3jcjm 224 9 the the DT cord-265139-x7g3jcjm 224 10 epigenetic epigenetic JJ cord-265139-x7g3jcjm 224 11 molecular molecular JJ cord-265139-x7g3jcjm 224 12 mechanisms mechanism NNS cord-265139-x7g3jcjm 224 13 of of IN cord-265139-x7g3jcjm 224 14 WAT WAT NNP cord-265139-x7g3jcjm 224 15 browning browning NNP cord-265139-x7g3jcjm 224 16 , , , cord-265139-x7g3jcjm 224 17 the the DT cord-265139-x7g3jcjm 224 18 role role NN cord-265139-x7g3jcjm 224 19 of of IN cord-265139-x7g3jcjm 224 20 ncRNAs ncRNAs NNP cord-265139-x7g3jcjm 224 21 , , , cord-265139-x7g3jcjm 224 22 a a DT cord-265139-x7g3jcjm 224 23 novel novel JJ cord-265139-x7g3jcjm 224 24 class class NN cord-265139-x7g3jcjm 224 25 of of IN cord-265139-x7g3jcjm 224 26 regulatory regulatory JJ cord-265139-x7g3jcjm 224 27 determinants determinant NNS cord-265139-x7g3jcjm 224 28 in in IN cord-265139-x7g3jcjm 224 29 this this DT cord-265139-x7g3jcjm 224 30 context context NN cord-265139-x7g3jcjm 224 31 is be VBZ cord-265139-x7g3jcjm 224 32 still still RB cord-265139-x7g3jcjm 224 33 mostly mostly RB cord-265139-x7g3jcjm 224 34 unknown unknown JJ cord-265139-x7g3jcjm 224 35 . . . cord-265139-x7g3jcjm 225 1 So so RB cord-265139-x7g3jcjm 225 2 far far RB cord-265139-x7g3jcjm 225 3 , , , cord-265139-x7g3jcjm 225 4 several several JJ cord-265139-x7g3jcjm 225 5 miRNAs miRNAs NNP cord-265139-x7g3jcjm 225 6 have have VBP cord-265139-x7g3jcjm 225 7 been be VBN cord-265139-x7g3jcjm 225 8 identified identify VBN cord-265139-x7g3jcjm 225 9 and and CC cord-265139-x7g3jcjm 225 10 characterized characterize VBN cord-265139-x7g3jcjm 225 11 to to TO cord-265139-x7g3jcjm 225 12 govern govern VB cord-265139-x7g3jcjm 225 13 WAT WAT NNP cord-265139-x7g3jcjm 225 14 browning browning NN cord-265139-x7g3jcjm 225 15 process process NN cord-265139-x7g3jcjm 225 16 [ [ -LRB- cord-265139-x7g3jcjm 225 17 107 107 CD cord-265139-x7g3jcjm 225 18 , , , cord-265139-x7g3jcjm 225 19 110 110 CD cord-265139-x7g3jcjm 225 20 ] ] -RRB- cord-265139-x7g3jcjm 225 21 . . . cord-265139-x7g3jcjm 226 1 Moreover moreover RB cord-265139-x7g3jcjm 226 2 , , , cord-265139-x7g3jcjm 226 3 a a DT cord-265139-x7g3jcjm 226 4 class class NN cord-265139-x7g3jcjm 226 5 of of IN cord-265139-x7g3jcjm 226 6 lncRNAs lncRNAs NNP cord-265139-x7g3jcjm 226 7 has have VBZ cord-265139-x7g3jcjm 226 8 also also RB cord-265139-x7g3jcjm 226 9 been be VBN cord-265139-x7g3jcjm 226 10 shown show VBN cord-265139-x7g3jcjm 226 11 to to TO cord-265139-x7g3jcjm 226 12 regulate regulate VB cord-265139-x7g3jcjm 226 13 brown brown JJ cord-265139-x7g3jcjm 226 14 adipogenesis adipogenesis NNP cord-265139-x7g3jcjm 226 15 [ [ -LRB- cord-265139-x7g3jcjm 226 16 80 80 CD cord-265139-x7g3jcjm 226 17 , , , cord-265139-x7g3jcjm 226 18 111 111 CD cord-265139-x7g3jcjm 226 19 ] ] -RRB- cord-265139-x7g3jcjm 226 20 . . . cord-265139-x7g3jcjm 227 1 With with IN cord-265139-x7g3jcjm 227 2 respect respect NN cord-265139-x7g3jcjm 227 3 to to IN cord-265139-x7g3jcjm 227 4 the the DT cord-265139-x7g3jcjm 227 5 potential potential JJ cord-265139-x7g3jcjm 227 6 implication implication NN cord-265139-x7g3jcjm 227 7 of of IN cord-265139-x7g3jcjm 227 8 circRNAs circrna NNS cord-265139-x7g3jcjm 227 9 in in IN cord-265139-x7g3jcjm 227 10 such such PDT cord-265139-x7g3jcjm 227 11 a a DT cord-265139-x7g3jcjm 227 12 process process NN cord-265139-x7g3jcjm 227 13 , , , cord-265139-x7g3jcjm 227 14 studies study NNS cord-265139-x7g3jcjm 227 15 are be VBP cord-265139-x7g3jcjm 227 16 only only RB cord-265139-x7g3jcjm 227 17 emerging emerge VBG cord-265139-x7g3jcjm 227 18 . . . cord-265139-x7g3jcjm 228 1 In in IN cord-265139-x7g3jcjm 228 2 this this DT cord-265139-x7g3jcjm 228 3 respect respect NN cord-265139-x7g3jcjm 228 4 , , , cord-265139-x7g3jcjm 228 5 Zhang Zhang NNP cord-265139-x7g3jcjm 228 6 et et NNP cord-265139-x7g3jcjm 228 7 al al NNP cord-265139-x7g3jcjm 228 8 . . NNP cord-265139-x7g3jcjm 228 9 reported report VBD cord-265139-x7g3jcjm 228 10 that that IN cord-265139-x7g3jcjm 228 11 plasma plasma NN cord-265139-x7g3jcjm 228 12 exosomal exosomal NNP cord-265139-x7g3jcjm 228 13 ciRS-133 ciRS-133 NNP cord-265139-x7g3jcjm 228 14 derived derive VBN cord-265139-x7g3jcjm 228 15 from from IN cord-265139-x7g3jcjm 228 16 gastric gastric JJ cord-265139-x7g3jcjm 228 17 cancer cancer NN cord-265139-x7g3jcjm 228 18 patient patient NN cord-265139-x7g3jcjm 228 19 cells cell NNS cord-265139-x7g3jcjm 228 20 promotes promote VBZ cord-265139-x7g3jcjm 228 21 WAT WAT NNP cord-265139-x7g3jcjm 228 22 browning browning NNP cord-265139-x7g3jcjm 228 23 by by IN cord-265139-x7g3jcjm 228 24 targeting target VBG cord-265139-x7g3jcjm 228 25 the the DT cord-265139-x7g3jcjm 228 26 miR-133 miR-133 NNP cord-265139-x7g3jcjm 228 27 / / SYM cord-265139-x7g3jcjm 228 28 PRDM16 PRDM16 NNP cord-265139-x7g3jcjm 228 29 pathway pathway NN cord-265139-x7g3jcjm 228 30 [ [ -LRB- cord-265139-x7g3jcjm 228 31 112 112 CD cord-265139-x7g3jcjm 228 32 ] ] -RRB- cord-265139-x7g3jcjm 228 33 . . . cord-265139-x7g3jcjm 229 1 In in IN cord-265139-x7g3jcjm 229 2 the the DT cord-265139-x7g3jcjm 229 3 same same JJ cord-265139-x7g3jcjm 229 4 manner manner NN cord-265139-x7g3jcjm 229 5 , , , cord-265139-x7g3jcjm 229 6 circNrxn2 circNrxn2 NNP cord-265139-x7g3jcjm 229 7 was be VBD cord-265139-x7g3jcjm 229 8 shown show VBN cord-265139-x7g3jcjm 229 9 to to TO cord-265139-x7g3jcjm 229 10 promote promote VB cord-265139-x7g3jcjm 229 11 WAT WAT NNP cord-265139-x7g3jcjm 229 12 browning browning NNP cord-265139-x7g3jcjm 229 13 by by IN cord-265139-x7g3jcjm 229 14 acting act VBG cord-265139-x7g3jcjm 229 15 as as IN cord-265139-x7g3jcjm 229 16 a a DT cord-265139-x7g3jcjm 229 17 miR-103 mir-103 NN cord-265139-x7g3jcjm 229 18 sponge sponge NN cord-265139-x7g3jcjm 229 19 ( ( -LRB- cord-265139-x7g3jcjm 229 20 Table table NN cord-265139-x7g3jcjm 229 21 1 1 CD cord-265139-x7g3jcjm 229 22 ) ) -RRB- cord-265139-x7g3jcjm 229 23 and and CC cord-265139-x7g3jcjm 229 24 enhance enhance VB cord-265139-x7g3jcjm 229 25 the the DT cord-265139-x7g3jcjm 229 26 expression expression NN cord-265139-x7g3jcjm 229 27 levels level NNS cord-265139-x7g3jcjm 229 28 of of IN cord-265139-x7g3jcjm 229 29 fibroblast fibroblast NN cord-265139-x7g3jcjm 229 30 growth growth NN cord-265139-x7g3jcjm 229 31 factor factor NN cord-265139-x7g3jcjm 229 32 10 10 CD cord-265139-x7g3jcjm 229 33 ( ( -LRB- cord-265139-x7g3jcjm 229 34 FGF10 FGF10 NNP cord-265139-x7g3jcjm 229 35 ) ) -RRB- cord-265139-x7g3jcjm 229 36 in in IN cord-265139-x7g3jcjm 229 37 HFD HFD NNP cord-265139-x7g3jcjm 229 38 mice mouse NNS cord-265139-x7g3jcjm 229 39 [ [ -LRB- cord-265139-x7g3jcjm 229 40 113 113 CD cord-265139-x7g3jcjm 229 41 ] ] -RRB- cord-265139-x7g3jcjm 229 42 . . . cord-265139-x7g3jcjm 230 1 Nonetheless nonetheless RB cord-265139-x7g3jcjm 230 2 , , , cord-265139-x7g3jcjm 230 3 these these DT cord-265139-x7g3jcjm 230 4 pilot pilot NN cord-265139-x7g3jcjm 230 5 studies study NNS cord-265139-x7g3jcjm 230 6 provide provide VBP cord-265139-x7g3jcjm 230 7 a a DT cord-265139-x7g3jcjm 230 8 great great JJ cord-265139-x7g3jcjm 230 9 potential potential JJ cord-265139-x7g3jcjm 230 10 therapeutic therapeutic JJ cord-265139-x7g3jcjm 230 11 strategy strategy NN cord-265139-x7g3jcjm 230 12 to to TO cord-265139-x7g3jcjm 230 13 reduce reduce VB cord-265139-x7g3jcjm 230 14 the the DT cord-265139-x7g3jcjm 230 15 excessive excessive JJ cord-265139-x7g3jcjm 230 16 energy energy NN cord-265139-x7g3jcjm 230 17 stores store NNS cord-265139-x7g3jcjm 230 18 in in IN cord-265139-x7g3jcjm 230 19 obesity obesity NN cord-265139-x7g3jcjm 230 20 . . . cord-265139-x7g3jcjm 231 1 Therefore therefore RB cord-265139-x7g3jcjm 231 2 , , , cord-265139-x7g3jcjm 231 3 further further JJ cord-265139-x7g3jcjm 231 4 investigation investigation NN cord-265139-x7g3jcjm 231 5 of of IN cord-265139-x7g3jcjm 231 6 the the DT cord-265139-x7g3jcjm 231 7 role role NN cord-265139-x7g3jcjm 231 8 of of IN cord-265139-x7g3jcjm 231 9 circRNAs circrna NNS cord-265139-x7g3jcjm 231 10 in in IN cord-265139-x7g3jcjm 231 11 WAT WAT NNP cord-265139-x7g3jcjm 231 12 browning browning NNP cord-265139-x7g3jcjm 231 13 program program NN cord-265139-x7g3jcjm 231 14 is be VBZ cord-265139-x7g3jcjm 231 15 needed need VBN cord-265139-x7g3jcjm 231 16 . . . cord-265139-x7g3jcjm 232 1 circRNAs circrna NNS cord-265139-x7g3jcjm 232 2 are be VBP cord-265139-x7g3jcjm 232 3 increasingly increasingly RB cord-265139-x7g3jcjm 232 4 being be VBG cord-265139-x7g3jcjm 232 5 recognized recognize VBN cord-265139-x7g3jcjm 232 6 to to TO cord-265139-x7g3jcjm 232 7 play play VB cord-265139-x7g3jcjm 232 8 essential essential JJ cord-265139-x7g3jcjm 232 9 roles role NNS cord-265139-x7g3jcjm 232 10 in in IN cord-265139-x7g3jcjm 232 11 several several JJ cord-265139-x7g3jcjm 232 12 diseases disease NNS cord-265139-x7g3jcjm 232 13 including include VBG cord-265139-x7g3jcjm 232 14 metabolic metabolic JJ cord-265139-x7g3jcjm 232 15 disorders disorder NNS cord-265139-x7g3jcjm 232 16 . . . cord-265139-x7g3jcjm 233 1 They -PRON- PRP cord-265139-x7g3jcjm 233 2 are be VBP cord-265139-x7g3jcjm 233 3 also also RB cord-265139-x7g3jcjm 233 4 emerging emerge VBG cord-265139-x7g3jcjm 233 5 as as IN cord-265139-x7g3jcjm 233 6 a a DT cord-265139-x7g3jcjm 233 7 novel novel JJ cord-265139-x7g3jcjm 233 8 regulatory regulatory JJ cord-265139-x7g3jcjm 233 9 layer layer NN cord-265139-x7g3jcjm 233 10 in in IN cord-265139-x7g3jcjm 233 11 adipogenesis adipogenesis NN cord-265139-x7g3jcjm 233 12 and and CC cord-265139-x7g3jcjm 233 13 lipid lipid NN cord-265139-x7g3jcjm 233 14 metabolism metabolism NN cord-265139-x7g3jcjm 233 15 involved involve VBN cord-265139-x7g3jcjm 233 16 in in IN cord-265139-x7g3jcjm 233 17 the the DT cord-265139-x7g3jcjm 233 18 development development NN cord-265139-x7g3jcjm 233 19 of of IN cord-265139-x7g3jcjm 233 20 obesity obesity NN cord-265139-x7g3jcjm 233 21 . . . cord-265139-x7g3jcjm 234 1 Yet yet RB cord-265139-x7g3jcjm 234 2 a a DT cord-265139-x7g3jcjm 234 3 number number NN cord-265139-x7g3jcjm 234 4 of of IN cord-265139-x7g3jcjm 234 5 key key JJ cord-265139-x7g3jcjm 234 6 questions question NNS cord-265139-x7g3jcjm 234 7 remain remain VBP cord-265139-x7g3jcjm 234 8 : : : cord-265139-x7g3jcjm 234 9 i i NN cord-265139-x7g3jcjm 234 10 ) ) -RRB- cord-265139-x7g3jcjm 235 1 While while IN cord-265139-x7g3jcjm 235 2 the the DT cord-265139-x7g3jcjm 235 3 studies study NNS cord-265139-x7g3jcjm 235 4 discussed discuss VBN cord-265139-x7g3jcjm 235 5 above above RB cord-265139-x7g3jcjm 235 6 have have VBP cord-265139-x7g3jcjm 235 7 confirmed confirm VBN cord-265139-x7g3jcjm 235 8 that that IN cord-265139-x7g3jcjm 235 9 circRNAs circrnas JJ cord-265139-x7g3jcjm 235 10 display display NN cord-265139-x7g3jcjm 235 11 altered alter VBD cord-265139-x7g3jcjm 235 12 expression expression NN cord-265139-x7g3jcjm 235 13 patterns pattern NNS cord-265139-x7g3jcjm 235 14 in in IN cord-265139-x7g3jcjm 235 15 adipose adipose JJ cord-265139-x7g3jcjm 235 16 tissue tissue NN cord-265139-x7g3jcjm 235 17 and and CC cord-265139-x7g3jcjm 235 18 obese obese JJ cord-265139-x7g3jcjm 235 19 individuals individual NNS cord-265139-x7g3jcjm 235 20 , , , cord-265139-x7g3jcjm 235 21 the the DT cord-265139-x7g3jcjm 235 22 cell cell NN cord-265139-x7g3jcjm 235 23 types type NNS cord-265139-x7g3jcjm 235 24 and and CC cord-265139-x7g3jcjm 235 25 tissue tissue NN cord-265139-x7g3jcjm 235 26 origin origin NN cord-265139-x7g3jcjm 235 27 of of IN cord-265139-x7g3jcjm 235 28 circRNAs circrna NNS cord-265139-x7g3jcjm 235 29 in in IN cord-265139-x7g3jcjm 235 30 obesity obesity NN cord-265139-x7g3jcjm 235 31 are be VBP cord-265139-x7g3jcjm 235 32 not not RB cord-265139-x7g3jcjm 235 33 yet yet RB cord-265139-x7g3jcjm 235 34 fully fully RB cord-265139-x7g3jcjm 235 35 explored explore VBN cord-265139-x7g3jcjm 235 36 . . . cord-265139-x7g3jcjm 236 1 This this DT cord-265139-x7g3jcjm 236 2 is be VBZ cord-265139-x7g3jcjm 236 3 very very RB cord-265139-x7g3jcjm 236 4 challenging challenging JJ cord-265139-x7g3jcjm 236 5 because because IN cord-265139-x7g3jcjm 236 6 obesity obesity NN cord-265139-x7g3jcjm 236 7 is be VBZ cord-265139-x7g3jcjm 236 8 a a DT cord-265139-x7g3jcjm 236 9 complicated complicated JJ cord-265139-x7g3jcjm 236 10 condition condition NN cord-265139-x7g3jcjm 236 11 involving involve VBG cord-265139-x7g3jcjm 236 12 many many JJ cord-265139-x7g3jcjm 236 13 tissues tissue NNS cord-265139-x7g3jcjm 236 14 and and CC cord-265139-x7g3jcjm 236 15 organs organ NNS cord-265139-x7g3jcjm 236 16 including include VBG cord-265139-x7g3jcjm 236 17 the the DT cord-265139-x7g3jcjm 236 18 muscle muscle NN cord-265139-x7g3jcjm 236 19 , , , cord-265139-x7g3jcjm 236 20 pancreas pancrea NNS cord-265139-x7g3jcjm 236 21 , , , cord-265139-x7g3jcjm 236 22 liver liver NN cord-265139-x7g3jcjm 236 23 , , , cord-265139-x7g3jcjm 236 24 and and CC cord-265139-x7g3jcjm 236 25 adipose adipose JJ cord-265139-x7g3jcjm 236 26 tissue tissue NN cord-265139-x7g3jcjm 236 27 . . . cord-265139-x7g3jcjm 237 1 In in IN cord-265139-x7g3jcjm 237 2 addition addition NN cord-265139-x7g3jcjm 237 3 , , , cord-265139-x7g3jcjm 237 4 there there EX cord-265139-x7g3jcjm 237 5 is be VBZ cord-265139-x7g3jcjm 237 6 growing grow VBG cord-265139-x7g3jcjm 237 7 evidence evidence NN cord-265139-x7g3jcjm 237 8 that that IN cord-265139-x7g3jcjm 237 9 WAT WAT NNP cord-265139-x7g3jcjm 237 10 is be VBZ cord-265139-x7g3jcjm 237 11 heterogeneous heterogeneous JJ cord-265139-x7g3jcjm 237 12 , , , cord-265139-x7g3jcjm 237 13 and and CC cord-265139-x7g3jcjm 237 14 adipocytes adipocyte NNS cord-265139-x7g3jcjm 237 15 are be VBP cord-265139-x7g3jcjm 237 16 only only RB cord-265139-x7g3jcjm 237 17 part part NN cord-265139-x7g3jcjm 237 18 of of IN cord-265139-x7g3jcjm 237 19 the the DT cord-265139-x7g3jcjm 237 20 adipose adipose JJ cord-265139-x7g3jcjm 237 21 deposit deposit NN cord-265139-x7g3jcjm 237 22 . . . cord-265139-x7g3jcjm 238 1 Furthermore furthermore RB cord-265139-x7g3jcjm 238 2 , , , cord-265139-x7g3jcjm 238 3 different different JJ cord-265139-x7g3jcjm 238 4 types type NNS cord-265139-x7g3jcjm 238 5 of of IN cord-265139-x7g3jcjm 238 6 adipocytes adipocyte NNS cord-265139-x7g3jcjm 238 7 have have VBP cord-265139-x7g3jcjm 238 8 differing differ VBG cord-265139-x7g3jcjm 238 9 metabolisms metabolism NNS cord-265139-x7g3jcjm 238 10 and and CC cord-265139-x7g3jcjm 238 11 their -PRON- PRP$ cord-265139-x7g3jcjm 238 12 ability ability NN cord-265139-x7g3jcjm 238 13 to to TO cord-265139-x7g3jcjm 238 14 communicate communicate VB cord-265139-x7g3jcjm 238 15 with with IN cord-265139-x7g3jcjm 238 16 other other JJ cord-265139-x7g3jcjm 238 17 metabolic metabolic JJ cord-265139-x7g3jcjm 238 18 organs organ NNS cord-265139-x7g3jcjm 238 19 through through IN cord-265139-x7g3jcjm 238 20 sending send VBG cord-265139-x7g3jcjm 238 21 out out RP cord-265139-x7g3jcjm 238 22 various various JJ cord-265139-x7g3jcjm 238 23 signaling signal VBG cord-265139-x7g3jcjm 238 24 molecules molecule NNS cord-265139-x7g3jcjm 238 25 and and CC cord-265139-x7g3jcjm 238 26 possibly possibly RB cord-265139-x7g3jcjm 238 27 ncRNAs ncRNAs NNP cord-265139-x7g3jcjm 238 28 may may MD cord-265139-x7g3jcjm 238 29 contribute contribute VB cord-265139-x7g3jcjm 238 30 to to IN cord-265139-x7g3jcjm 238 31 the the DT cord-265139-x7g3jcjm 238 32 regulation regulation NN cord-265139-x7g3jcjm 238 33 of of IN cord-265139-x7g3jcjm 238 34 systemic systemic JJ cord-265139-x7g3jcjm 238 35 energy energy NN cord-265139-x7g3jcjm 238 36 homeostasis homeostasis NN cord-265139-x7g3jcjm 238 37 differently differently RB cord-265139-x7g3jcjm 238 38 [ [ -LRB- cord-265139-x7g3jcjm 238 39 114 114 CD cord-265139-x7g3jcjm 238 40 , , , cord-265139-x7g3jcjm 238 41 115 115 CD cord-265139-x7g3jcjm 238 42 ] ] -RRB- cord-265139-x7g3jcjm 238 43 . . . cord-265139-x7g3jcjm 239 1 Therefore therefore RB cord-265139-x7g3jcjm 239 2 , , , cord-265139-x7g3jcjm 239 3 part part NN cord-265139-x7g3jcjm 239 4 of of IN cord-265139-x7g3jcjm 239 5 the the DT cord-265139-x7g3jcjm 239 6 solution solution NN cord-265139-x7g3jcjm 239 7 to to IN cord-265139-x7g3jcjm 239 8 these these DT cord-265139-x7g3jcjm 239 9 hurdles hurdle NNS cord-265139-x7g3jcjm 239 10 may may MD cord-265139-x7g3jcjm 239 11 be be VB cord-265139-x7g3jcjm 239 12 achieved achieve VBN cord-265139-x7g3jcjm 239 13 by by IN cord-265139-x7g3jcjm 239 14 1 1 CD cord-265139-x7g3jcjm 239 15 ) ) -RRB- cord-265139-x7g3jcjm 239 16 discriminating discriminate VBG cord-265139-x7g3jcjm 239 17 the the DT cord-265139-x7g3jcjm 239 18 cellular cellular JJ cord-265139-x7g3jcjm 239 19 origin origin NN cord-265139-x7g3jcjm 239 20 of of IN cord-265139-x7g3jcjm 239 21 secreted secrete VBN cord-265139-x7g3jcjm 239 22 circRNAs circrna NNS cord-265139-x7g3jcjm 239 23 in in IN cord-265139-x7g3jcjm 239 24 order order NN cord-265139-x7g3jcjm 239 25 to to TO cord-265139-x7g3jcjm 239 26 identify identify VB cord-265139-x7g3jcjm 239 27 those those DT cord-265139-x7g3jcjm 239 28 involved involve VBN cord-265139-x7g3jcjm 239 29 in in IN cord-265139-x7g3jcjm 239 30 tissue tissue NN cord-265139-x7g3jcjm 239 31 function function NN cord-265139-x7g3jcjm 239 32 in in IN cord-265139-x7g3jcjm 239 33 health health NN cord-265139-x7g3jcjm 239 34 and and CC cord-265139-x7g3jcjm 239 35 dysfunction dysfunction NN cord-265139-x7g3jcjm 239 36 in in IN cord-265139-x7g3jcjm 239 37 disease disease NN cord-265139-x7g3jcjm 239 38 ; ; : cord-265139-x7g3jcjm 239 39 2 2 LS cord-265139-x7g3jcjm 239 40 ) ) -RRB- cord-265139-x7g3jcjm 239 41 identifying identify VBG cord-265139-x7g3jcjm 239 42 potential potential JJ cord-265139-x7g3jcjm 239 43 circRNAs circrna NNS cord-265139-x7g3jcjm 239 44 mediating mediate VBG cord-265139-x7g3jcjm 239 45 inter inter JJ cord-265139-x7g3jcjm 239 46 - - JJ cord-265139-x7g3jcjm 239 47 organ organ JJ cord-265139-x7g3jcjm 239 48 metabolic metabolic JJ cord-265139-x7g3jcjm 239 49 communication communication NN cord-265139-x7g3jcjm 239 50 as as RB cord-265139-x7g3jcjm 239 51 well well RB cord-265139-x7g3jcjm 239 52 as as IN cord-265139-x7g3jcjm 239 53 those those DT cord-265139-x7g3jcjm 239 54 that that WDT cord-265139-x7g3jcjm 239 55 my -PRON- PRP$ cord-265139-x7g3jcjm 239 56 impact impact NN cord-265139-x7g3jcjm 239 57 homeostasis homeostasis NN cord-265139-x7g3jcjm 239 58 in in IN cord-265139-x7g3jcjm 239 59 case case NN cord-265139-x7g3jcjm 239 60 of of IN cord-265139-x7g3jcjm 239 61 organ organ NN cord-265139-x7g3jcjm 239 62 failure failure NN cord-265139-x7g3jcjm 239 63 ; ; : cord-265139-x7g3jcjm 239 64 and and CC cord-265139-x7g3jcjm 239 65 3 3 LS cord-265139-x7g3jcjm 239 66 ) ) -RRB- cord-265139-x7g3jcjm 239 67 characterizing characterize VBG cord-265139-x7g3jcjm 239 68 natural natural JJ cord-265139-x7g3jcjm 239 69 circRNAs circRNAs NNP cord-265139-x7g3jcjm 239 70 carriers carrier NNS cord-265139-x7g3jcjm 239 71 to to TO cord-265139-x7g3jcjm 239 72 reach reach VB cord-265139-x7g3jcjm 239 73 distant distant JJ cord-265139-x7g3jcjm 239 74 organs organ NNS cord-265139-x7g3jcjm 239 75 . . . cord-265139-x7g3jcjm 240 1 ii ii LS cord-265139-x7g3jcjm 240 2 ) ) -RRB- cord-265139-x7g3jcjm 241 1 The the DT cord-265139-x7g3jcjm 241 2 potential potential JJ cord-265139-x7g3jcjm 241 3 role role NN cord-265139-x7g3jcjm 241 4 of of IN cord-265139-x7g3jcjm 241 5 exosomal exosomal NNP cord-265139-x7g3jcjm 241 6 circRNA circRNA NNP cord-265139-x7g3jcjm 241 7 signature signature NN cord-265139-x7g3jcjm 241 8 in in IN cord-265139-x7g3jcjm 241 9 the the DT cord-265139-x7g3jcjm 241 10 development development NN cord-265139-x7g3jcjm 241 11 of of IN cord-265139-x7g3jcjm 241 12 obesity obesity NN cord-265139-x7g3jcjm 241 13 and and CC cord-265139-x7g3jcjm 241 14 related related JJ cord-265139-x7g3jcjm 241 15 complications complication NNS cord-265139-x7g3jcjm 241 16 remains remain VBZ cord-265139-x7g3jcjm 241 17 largely largely RB cord-265139-x7g3jcjm 241 18 unknown unknown JJ cord-265139-x7g3jcjm 241 19 . . . cord-265139-x7g3jcjm 242 1 Several several JJ cord-265139-x7g3jcjm 242 2 studies study NNS cord-265139-x7g3jcjm 242 3 found find VBD cord-265139-x7g3jcjm 242 4 that that IN cord-265139-x7g3jcjm 242 5 ncRNAs ncRNAs NNP cord-265139-x7g3jcjm 242 6 in in IN cord-265139-x7g3jcjm 242 7 secreted secrete VBN cord-265139-x7g3jcjm 242 8 exosomes exosome NNS cord-265139-x7g3jcjm 242 9 can can MD cord-265139-x7g3jcjm 242 10 be be VB cord-265139-x7g3jcjm 242 11 transferred transfer VBN cord-265139-x7g3jcjm 242 12 to to TO cord-265139-x7g3jcjm 242 13 target target VB cord-265139-x7g3jcjm 242 14 tissues tissue NNS cord-265139-x7g3jcjm 242 15 or or CC cord-265139-x7g3jcjm 242 16 cells cell NNS cord-265139-x7g3jcjm 242 17 to to TO cord-265139-x7g3jcjm 242 18 exert exert VB cord-265139-x7g3jcjm 242 19 function function NN cord-265139-x7g3jcjm 242 20 [ [ -LRB- cord-265139-x7g3jcjm 242 21 116 116 CD cord-265139-x7g3jcjm 242 22 ] ] -RRB- cord-265139-x7g3jcjm 242 23 . . . cord-265139-x7g3jcjm 243 1 Furthermore furthermore RB cord-265139-x7g3jcjm 243 2 , , , cord-265139-x7g3jcjm 243 3 adipocytes adipocyte NNS cord-265139-x7g3jcjm 243 4 have have VBP cord-265139-x7g3jcjm 243 5 been be VBN cord-265139-x7g3jcjm 243 6 shown show VBN cord-265139-x7g3jcjm 243 7 to to TO cord-265139-x7g3jcjm 243 8 produce produce VB cord-265139-x7g3jcjm 243 9 and and CC cord-265139-x7g3jcjm 243 10 release release VB cord-265139-x7g3jcjm 243 11 vesicles vesicle NNS cord-265139-x7g3jcjm 243 12 containing contain VBG cord-265139-x7g3jcjm 243 13 genetic genetic JJ cord-265139-x7g3jcjm 243 14 material material NN cord-265139-x7g3jcjm 243 15 to to TO cord-265139-x7g3jcjm 243 16 communicate communicate VB cord-265139-x7g3jcjm 243 17 with with IN cord-265139-x7g3jcjm 243 18 neighboring neighboring NN cord-265139-x7g3jcjm 243 19 cells cell NNS cord-265139-x7g3jcjm 243 20 within within IN cord-265139-x7g3jcjm 243 21 WAT WAT NNP cord-265139-x7g3jcjm 243 22 or or CC cord-265139-x7g3jcjm 243 23 facilitate facilitate VB cord-265139-x7g3jcjm 243 24 metabolic metabolic JJ cord-265139-x7g3jcjm 243 25 organs organ NNS cord-265139-x7g3jcjm 243 26 crosstalk crosstalk VB cord-265139-x7g3jcjm 243 27 [ [ -LRB- cord-265139-x7g3jcjm 243 28 117 117 CD cord-265139-x7g3jcjm 243 29 , , , cord-265139-x7g3jcjm 243 30 118 118 CD cord-265139-x7g3jcjm 243 31 ] ] -RRB- cord-265139-x7g3jcjm 243 32 . . . cord-265139-x7g3jcjm 244 1 Clear clear JJ cord-265139-x7g3jcjm 244 2 and and CC cord-265139-x7g3jcjm 244 3 convincing convincing JJ cord-265139-x7g3jcjm 244 4 evidence evidence NN cord-265139-x7g3jcjm 244 5 of of IN cord-265139-x7g3jcjm 244 6 this this DT cord-265139-x7g3jcjm 244 7 phenomenon phenomenon NN cord-265139-x7g3jcjm 244 8 is be VBZ cord-265139-x7g3jcjm 244 9 provided provide VBN cord-265139-x7g3jcjm 244 10 by by IN cord-265139-x7g3jcjm 244 11 a a DT cord-265139-x7g3jcjm 244 12 recent recent JJ cord-265139-x7g3jcjm 244 13 study study NN cord-265139-x7g3jcjm 244 14 showing show VBG cord-265139-x7g3jcjm 244 15 that that IN cord-265139-x7g3jcjm 244 16 adipose adipose JJ cord-265139-x7g3jcjm 244 17 tissue tissue NN cord-265139-x7g3jcjm 244 18 can can MD cord-265139-x7g3jcjm 244 19 release release VB cord-265139-x7g3jcjm 244 20 miRNAs miRNAs NNP cord-265139-x7g3jcjm 244 21 in in IN cord-265139-x7g3jcjm 244 22 the the DT cord-265139-x7g3jcjm 244 23 circulation circulation NN cord-265139-x7g3jcjm 244 24 [ [ -LRB- cord-265139-x7g3jcjm 244 25 115 115 CD cord-265139-x7g3jcjm 244 26 ] ] -RRB- cord-265139-x7g3jcjm 244 27 which which WDT cord-265139-x7g3jcjm 244 28 can can MD cord-265139-x7g3jcjm 244 29 regulate regulate VB cord-265139-x7g3jcjm 244 30 gene gene NN cord-265139-x7g3jcjm 244 31 expression expression NN cord-265139-x7g3jcjm 244 32 in in IN cord-265139-x7g3jcjm 244 33 other other JJ cord-265139-x7g3jcjm 244 34 distant distant JJ cord-265139-x7g3jcjm 244 35 metabolic metabolic JJ cord-265139-x7g3jcjm 244 36 organs organ NNS cord-265139-x7g3jcjm 244 37 . . . cord-265139-x7g3jcjm 245 1 Moreover moreover RB cord-265139-x7g3jcjm 245 2 , , , cord-265139-x7g3jcjm 245 3 adipose adipose JJ cord-265139-x7g3jcjm 245 4 tissue tissue NN cord-265139-x7g3jcjm 245 5 macrophages macrophage NNS cord-265139-x7g3jcjm 245 6 in in IN cord-265139-x7g3jcjm 245 7 obese obese JJ cord-265139-x7g3jcjm 245 8 mice mouse NNS cord-265139-x7g3jcjm 245 9 can can MD cord-265139-x7g3jcjm 245 10 secrete secrete VB cord-265139-x7g3jcjm 245 11 miRNA miRNA NNP cord-265139-x7g3jcjm 245 12 - - HYPH cord-265139-x7g3jcjm 245 13 containing contain VBG cord-265139-x7g3jcjm 245 14 exosomes exosome NNS cord-265139-x7g3jcjm 245 15 , , , cord-265139-x7g3jcjm 245 16 which which WDT cord-265139-x7g3jcjm 245 17 cause cause VBP cord-265139-x7g3jcjm 245 18 glucose glucose NN cord-265139-x7g3jcjm 245 19 intolerance intolerance NN cord-265139-x7g3jcjm 245 20 and and CC cord-265139-x7g3jcjm 245 21 IR IR NNP cord-265139-x7g3jcjm 245 22 when when WRB cord-265139-x7g3jcjm 245 23 administered administer VBN cord-265139-x7g3jcjm 245 24 to to TO cord-265139-x7g3jcjm 245 25 lean lean VB cord-265139-x7g3jcjm 245 26 mice mouse NNS cord-265139-x7g3jcjm 245 27 [ [ -LRB- cord-265139-x7g3jcjm 245 28 116 116 CD cord-265139-x7g3jcjm 245 29 ] ] -RRB- cord-265139-x7g3jcjm 245 30 . . . cord-265139-x7g3jcjm 246 1 With with IN cord-265139-x7g3jcjm 246 2 respect respect NN cord-265139-x7g3jcjm 246 3 to to IN cord-265139-x7g3jcjm 246 4 circRNAs circrna NNS cord-265139-x7g3jcjm 246 5 found find VBN cord-265139-x7g3jcjm 246 6 in in IN cord-265139-x7g3jcjm 246 7 adipose adipose JJ cord-265139-x7g3jcjm 246 8 tissues tissue NNS cord-265139-x7g3jcjm 246 9 , , , cord-265139-x7g3jcjm 246 10 they -PRON- PRP cord-265139-x7g3jcjm 246 11 may may MD cord-265139-x7g3jcjm 246 12 also also RB cord-265139-x7g3jcjm 246 13 be be VB cord-265139-x7g3jcjm 246 14 released release VBN cord-265139-x7g3jcjm 246 15 to to IN cord-265139-x7g3jcjm 246 16 the the DT cord-265139-x7g3jcjm 246 17 circulation circulation NN cord-265139-x7g3jcjm 246 18 inside inside IN cord-265139-x7g3jcjm 246 19 macrovesicles macrovesicle NNS cord-265139-x7g3jcjm 246 20 and and CC cord-265139-x7g3jcjm 246 21 have have VBP cord-265139-x7g3jcjm 246 22 functions function NNS cord-265139-x7g3jcjm 246 23 in in IN cord-265139-x7g3jcjm 246 24 target target NN cord-265139-x7g3jcjm 246 25 organs organ NNS cord-265139-x7g3jcjm 246 26 . . . cord-265139-x7g3jcjm 247 1 In in IN cord-265139-x7g3jcjm 247 2 support support NN cord-265139-x7g3jcjm 247 3 of of IN cord-265139-x7g3jcjm 247 4 this this DT cord-265139-x7g3jcjm 247 5 assumption assumption NN cord-265139-x7g3jcjm 247 6 , , , cord-265139-x7g3jcjm 247 7 a a DT cord-265139-x7g3jcjm 247 8 recent recent JJ cord-265139-x7g3jcjm 247 9 report report NN cord-265139-x7g3jcjm 247 10 indicated indicate VBD cord-265139-x7g3jcjm 247 11 that that IN cord-265139-x7g3jcjm 247 12 adipose adipose NN cord-265139-x7g3jcjm 247 13 - - HYPH cord-265139-x7g3jcjm 247 14 derived derive VBN cord-265139-x7g3jcjm 247 15 exosomes exosome NNS cord-265139-x7g3jcjm 247 16 mediate mediate VBP cord-265139-x7g3jcjm 247 17 the the DT cord-265139-x7g3jcjm 247 18 delivery delivery NN cord-265139-x7g3jcjm 247 19 of of IN cord-265139-x7g3jcjm 247 20 circRNAs circrna NNS cord-265139-x7g3jcjm 247 21 and and CC cord-265139-x7g3jcjm 247 22 promote promote VB cord-265139-x7g3jcjm 247 23 the the DT cord-265139-x7g3jcjm 247 24 tumorigenesis tumorigenesis NN cord-265139-x7g3jcjm 247 25 of of IN cord-265139-x7g3jcjm 247 26 hepatocellular hepatocellular JJ cord-265139-x7g3jcjm 247 27 carcinoma carcinoma NN cord-265139-x7g3jcjm 247 28 ( ( -LRB- cord-265139-x7g3jcjm 247 29 HCC HCC NNP cord-265139-x7g3jcjm 247 30 ) ) -RRB- cord-265139-x7g3jcjm 247 31 by by IN cord-265139-x7g3jcjm 247 32 regulating regulate VBG cord-265139-x7g3jcjm 247 33 the the DT cord-265139-x7g3jcjm 247 34 deubiquitination deubiquitination NN cord-265139-x7g3jcjm 247 35 - - HYPH cord-265139-x7g3jcjm 247 36 related relate VBN cord-265139-x7g3jcjm 247 37 miR-34a miR-34a NNP cord-265139-x7g3jcjm 247 38 / / SYM cord-265139-x7g3jcjm 247 39 USP7 USP7 NNP cord-265139-x7g3jcjm 247 40 axis axis NN cord-265139-x7g3jcjm 247 41 [ [ -LRB- cord-265139-x7g3jcjm 247 42 119 119 CD cord-265139-x7g3jcjm 247 43 ] ] -RRB- cord-265139-x7g3jcjm 247 44 . . . cord-265139-x7g3jcjm 248 1 As as IN cord-265139-x7g3jcjm 248 2 stated state VBN cord-265139-x7g3jcjm 248 3 above above RB cord-265139-x7g3jcjm 248 4 , , , cord-265139-x7g3jcjm 248 5 a a DT cord-265139-x7g3jcjm 248 6 study study NN cord-265139-x7g3jcjm 248 7 by by IN cord-265139-x7g3jcjm 248 8 Zhang Zhang NNP cord-265139-x7g3jcjm 248 9 et et NNP cord-265139-x7g3jcjm 248 10 al al NNP cord-265139-x7g3jcjm 248 11 . . NNP cord-265139-x7g3jcjm 248 12 revealed reveal VBD cord-265139-x7g3jcjm 248 13 that that IN cord-265139-x7g3jcjm 248 14 exosomal exosomal NNP cord-265139-x7g3jcjm 248 15 circRNA circRNA NNP cord-265139-x7g3jcjm 248 16 derived derive VBN cord-265139-x7g3jcjm 248 17 from from IN cord-265139-x7g3jcjm 248 18 gastric gastric JJ cord-265139-x7g3jcjm 248 19 tumor tumor NN cord-265139-x7g3jcjm 248 20 promotes promote VBZ cord-265139-x7g3jcjm 248 21 white white JJ cord-265139-x7g3jcjm 248 22 adipose adipose JJ cord-265139-x7g3jcjm 248 23 browning browning NN cord-265139-x7g3jcjm 248 24 by by IN cord-265139-x7g3jcjm 248 25 targeting target VBG cord-265139-x7g3jcjm 248 26 miR-133 miR-133 NNP cord-265139-x7g3jcjm 248 27 [ [ -LRB- cord-265139-x7g3jcjm 248 28 112 112 CD cord-265139-x7g3jcjm 248 29 ] ] -RRB- cord-265139-x7g3jcjm 248 30 . . . cord-265139-x7g3jcjm 249 1 Moreover moreover RB cord-265139-x7g3jcjm 249 2 , , , cord-265139-x7g3jcjm 249 3 exosomal exosomal NNS cord-265139-x7g3jcjm 249 4 circRNAs circrna NNS cord-265139-x7g3jcjm 249 5 have have VBP cord-265139-x7g3jcjm 249 6 been be VBN cord-265139-x7g3jcjm 249 7 suggested suggest VBN cord-265139-x7g3jcjm 249 8 as as IN cord-265139-x7g3jcjm 249 9 circulating circulate VBG cord-265139-x7g3jcjm 249 10 biomarkers biomarker NNS cord-265139-x7g3jcjm 249 11 for for IN cord-265139-x7g3jcjm 249 12 the the DT cord-265139-x7g3jcjm 249 13 diagnosis diagnosis NN cord-265139-x7g3jcjm 249 14 of of IN cord-265139-x7g3jcjm 249 15 cancer cancer NN cord-265139-x7g3jcjm 249 16 as as IN cord-265139-x7g3jcjm 249 17 they -PRON- PRP cord-265139-x7g3jcjm 249 18 have have VBP cord-265139-x7g3jcjm 249 19 been be VBN cord-265139-x7g3jcjm 249 20 shown show VBN cord-265139-x7g3jcjm 249 21 to to TO cord-265139-x7g3jcjm 249 22 discriminate discriminate VB cord-265139-x7g3jcjm 249 23 patients patient NNS cord-265139-x7g3jcjm 249 24 with with IN cord-265139-x7g3jcjm 249 25 cancer cancer NN cord-265139-x7g3jcjm 249 26 from from IN cord-265139-x7g3jcjm 249 27 healthy healthy JJ cord-265139-x7g3jcjm 249 28 controls control NNS cord-265139-x7g3jcjm 249 29 [ [ -LRB- cord-265139-x7g3jcjm 249 30 120 120 CD cord-265139-x7g3jcjm 249 31 ] ] -RRB- cord-265139-x7g3jcjm 249 32 . . . cord-265139-x7g3jcjm 250 1 However however RB cord-265139-x7g3jcjm 250 2 , , , cord-265139-x7g3jcjm 250 3 how how WRB cord-265139-x7g3jcjm 250 4 many many JJ cord-265139-x7g3jcjm 250 5 copies copy NNS cord-265139-x7g3jcjm 250 6 of of IN cord-265139-x7g3jcjm 250 7 circRNA circrna NN cord-265139-x7g3jcjm 250 8 molecules molecule NNS cord-265139-x7g3jcjm 250 9 these these DT cord-265139-x7g3jcjm 250 10 exosomes exosome NNS cord-265139-x7g3jcjm 250 11 harbor harbor NN cord-265139-x7g3jcjm 250 12 needs need NNS cord-265139-x7g3jcjm 250 13 to to TO cord-265139-x7g3jcjm 250 14 be be VB cord-265139-x7g3jcjm 250 15 evaluated evaluate VBN cord-265139-x7g3jcjm 250 16 . . . cord-265139-x7g3jcjm 251 1 Further further RB cord-265139-x7g3jcjm 251 2 , , , cord-265139-x7g3jcjm 251 3 more more RBR cord-265139-x7g3jcjm 251 4 in in IN cord-265139-x7g3jcjm 251 5 vitro vitro FW cord-265139-x7g3jcjm 251 6 and and CC cord-265139-x7g3jcjm 251 7 in in IN cord-265139-x7g3jcjm 251 8 vivo vivo NN cord-265139-x7g3jcjm 251 9 modeling modeling NN cord-265139-x7g3jcjm 251 10 of of IN cord-265139-x7g3jcjm 251 11 exosome exosome NN cord-265139-x7g3jcjm 251 12 - - HYPH cord-265139-x7g3jcjm 251 13 mediated mediate VBN cord-265139-x7g3jcjm 251 14 circRNA circrna NN cord-265139-x7g3jcjm 251 15 communication communication NN cord-265139-x7g3jcjm 251 16 along along IN cord-265139-x7g3jcjm 251 17 with with IN cord-265139-x7g3jcjm 251 18 development development NN cord-265139-x7g3jcjm 251 19 of of IN cord-265139-x7g3jcjm 251 20 sensitive sensitive JJ cord-265139-x7g3jcjm 251 21 bioinformatic bioinformatic JJ cord-265139-x7g3jcjm 251 22 methods method NNS cord-265139-x7g3jcjm 251 23 and and CC cord-265139-x7g3jcjm 251 24 mathematical mathematical JJ cord-265139-x7g3jcjm 251 25 mass mass JJ cord-265139-x7g3jcjm 251 26 - - HYPH cord-265139-x7g3jcjm 251 27 action action NN cord-265139-x7g3jcjm 251 28 models model NNS cord-265139-x7g3jcjm 251 29 to to TO cord-265139-x7g3jcjm 251 30 capture capture VB cord-265139-x7g3jcjm 251 31 all all DT cord-265139-x7g3jcjm 251 32 circRNA circrna JJ cord-265139-x7g3jcjm 251 33 - - HYPH cord-265139-x7g3jcjm 251 34 target target NN cord-265139-x7g3jcjm 251 35 interactions interaction NNS cord-265139-x7g3jcjm 251 36 , , , cord-265139-x7g3jcjm 251 37 will will MD cord-265139-x7g3jcjm 251 38 undoubtedly undoubtedly RB cord-265139-x7g3jcjm 251 39 provide provide VB cord-265139-x7g3jcjm 251 40 insight insight NN cord-265139-x7g3jcjm 251 41 into into IN cord-265139-x7g3jcjm 251 42 the the DT cord-265139-x7g3jcjm 251 43 function function NN cord-265139-x7g3jcjm 251 44 of of IN cord-265139-x7g3jcjm 251 45 these these DT cord-265139-x7g3jcjm 251 46 exosomal exosomal VBN cord-265139-x7g3jcjm 251 47 RNA RNA NNP cord-265139-x7g3jcjm 251 48 species specie NNS cord-265139-x7g3jcjm 251 49 . . . cord-265139-x7g3jcjm 252 1 Further further JJ cord-265139-x7g3jcjm 252 2 stoichiometric stoichiometric JJ cord-265139-x7g3jcjm 252 3 analysis analysis NN cord-265139-x7g3jcjm 252 4 is be VBZ cord-265139-x7g3jcjm 252 5 required require VBN cord-265139-x7g3jcjm 252 6 to to TO cord-265139-x7g3jcjm 252 7 better better RB cord-265139-x7g3jcjm 252 8 explore explore VB cord-265139-x7g3jcjm 252 9 circRNA circRNA NNP cord-265139-x7g3jcjm 252 10 - - HYPH cord-265139-x7g3jcjm 252 11 miRNA miRNA NNP cord-265139-x7g3jcjm 252 12 and and CC cord-265139-x7g3jcjm 252 13 circRNA circRNA NNP cord-265139-x7g3jcjm 252 14 - - HYPH cord-265139-x7g3jcjm 252 15 RBP rbp NN cord-265139-x7g3jcjm 252 16 interactions interaction NNS cord-265139-x7g3jcjm 252 17 . . . cord-265139-x7g3jcjm 253 1 Success success NN cord-265139-x7g3jcjm 253 2 in in IN cord-265139-x7g3jcjm 253 3 addressing address VBG cord-265139-x7g3jcjm 253 4 all all PDT cord-265139-x7g3jcjm 253 5 these these DT cord-265139-x7g3jcjm 253 6 issues issue NNS cord-265139-x7g3jcjm 253 7 may may MD cord-265139-x7g3jcjm 253 8 clarify clarify VB cord-265139-x7g3jcjm 253 9 the the DT cord-265139-x7g3jcjm 253 10 controversy controversy NN cord-265139-x7g3jcjm 253 11 surrounding surround VBG cord-265139-x7g3jcjm 253 12 the the DT cord-265139-x7g3jcjm 253 13 sponging sponging NN cord-265139-x7g3jcjm 253 14 function function NN cord-265139-x7g3jcjm 253 15 of of IN cord-265139-x7g3jcjm 253 16 circRNAs circrna NNS cord-265139-x7g3jcjm 253 17 . . . cord-265139-x7g3jcjm 254 1 iii iii LS cord-265139-x7g3jcjm 254 2 ) ) -RRB- cord-265139-x7g3jcjm 255 1 circRNAs circrna NNS cord-265139-x7g3jcjm 255 2 have have VBP cord-265139-x7g3jcjm 255 3 also also RB cord-265139-x7g3jcjm 255 4 been be VBN cord-265139-x7g3jcjm 255 5 reported report VBN cord-265139-x7g3jcjm 255 6 to to TO cord-265139-x7g3jcjm 255 7 bind bind VB cord-265139-x7g3jcjm 255 8 , , , cord-265139-x7g3jcjm 255 9 store store VB cord-265139-x7g3jcjm 255 10 , , , cord-265139-x7g3jcjm 255 11 and and CC cord-265139-x7g3jcjm 255 12 even even RB cord-265139-x7g3jcjm 255 13 insulate insulate VB cord-265139-x7g3jcjm 255 14 RBPs rbp NNS cord-265139-x7g3jcjm 255 15 from from IN cord-265139-x7g3jcjm 255 16 specific specific JJ cord-265139-x7g3jcjm 255 17 subcellular subcellular JJ cord-265139-x7g3jcjm 255 18 sites site NNS cord-265139-x7g3jcjm 255 19 or or CC cord-265139-x7g3jcjm 255 20 act act VB cord-265139-x7g3jcjm 255 21 as as IN cord-265139-x7g3jcjm 255 22 competitive competitive JJ cord-265139-x7g3jcjm 255 23 elements element NNS cord-265139-x7g3jcjm 255 24 to to TO cord-265139-x7g3jcjm 255 25 influence influence VB cord-265139-x7g3jcjm 255 26 the the DT cord-265139-x7g3jcjm 255 27 function function NN cord-265139-x7g3jcjm 255 28 of of IN cord-265139-x7g3jcjm 255 29 RBPs RBPs NNP cord-265139-x7g3jcjm 255 30 . . . cord-265139-x7g3jcjm 256 1 However however RB cord-265139-x7g3jcjm 256 2 , , , cord-265139-x7g3jcjm 256 3 to to IN cord-265139-x7g3jcjm 256 4 my -PRON- PRP$ cord-265139-x7g3jcjm 256 5 knowledge knowledge NN cord-265139-x7g3jcjm 256 6 , , , cord-265139-x7g3jcjm 256 7 no no DT cord-265139-x7g3jcjm 256 8 one one NN cord-265139-x7g3jcjm 256 9 has have VBZ cord-265139-x7g3jcjm 256 10 specifically specifically RB cord-265139-x7g3jcjm 256 11 interrogated interrogate VBN cord-265139-x7g3jcjm 256 12 the the DT cord-265139-x7g3jcjm 256 13 role role NN cord-265139-x7g3jcjm 256 14 of of IN cord-265139-x7g3jcjm 256 15 circRNA circrna JJ cord-265139-x7g3jcjm 256 16 - - HYPH cord-265139-x7g3jcjm 256 17 RBP rbp NN cord-265139-x7g3jcjm 256 18 axis axis NN cord-265139-x7g3jcjm 256 19 in in IN cord-265139-x7g3jcjm 256 20 adipose adipose JJ cord-265139-x7g3jcjm 256 21 tissue tissue NN cord-265139-x7g3jcjm 256 22 and and CC cord-265139-x7g3jcjm 256 23 obesity obesity NN cord-265139-x7g3jcjm 256 24 processes process NNS cord-265139-x7g3jcjm 256 25 . . . cord-265139-x7g3jcjm 257 1 Several several JJ cord-265139-x7g3jcjm 257 2 RBPs rbp NNS cord-265139-x7g3jcjm 257 3 have have VBP cord-265139-x7g3jcjm 257 4 been be VBN cord-265139-x7g3jcjm 257 5 reported report VBN cord-265139-x7g3jcjm 257 6 as as IN cord-265139-x7g3jcjm 257 7 adipocyte adipocyte NN cord-265139-x7g3jcjm 257 8 regulators regulator NNS cord-265139-x7g3jcjm 257 9 by by IN cord-265139-x7g3jcjm 257 10 affecting affect VBG cord-265139-x7g3jcjm 257 11 different different JJ cord-265139-x7g3jcjm 257 12 aspects aspect NNS cord-265139-x7g3jcjm 257 13 of of IN cord-265139-x7g3jcjm 257 14 RNA RNA NNP cord-265139-x7g3jcjm 257 15 processing processing NN cord-265139-x7g3jcjm 257 16 . . . cord-265139-x7g3jcjm 258 1 For for IN cord-265139-x7g3jcjm 258 2 example example NN cord-265139-x7g3jcjm 258 3 , , , cord-265139-x7g3jcjm 258 4 the the DT cord-265139-x7g3jcjm 258 5 RNA RNA NNP cord-265139-x7g3jcjm 258 6 - - HYPH cord-265139-x7g3jcjm 258 7 binding bind VBG cord-265139-x7g3jcjm 258 8 protein protein NN cord-265139-x7g3jcjm 258 9 PSPC1 PSPC1 NNP cord-265139-x7g3jcjm 258 10 ( ( -LRB- cord-265139-x7g3jcjm 258 11 paraspeckle paraspeckle NN cord-265139-x7g3jcjm 258 12 component component NN cord-265139-x7g3jcjm 258 13 1 1 CD cord-265139-x7g3jcjm 258 14 ) ) -RRB- cord-265139-x7g3jcjm 258 15 has have VBZ cord-265139-x7g3jcjm 258 16 been be VBN cord-265139-x7g3jcjm 258 17 identified identify VBN cord-265139-x7g3jcjm 258 18 as as IN cord-265139-x7g3jcjm 258 19 an an DT cord-265139-x7g3jcjm 258 20 adipogenic adipogenic JJ cord-265139-x7g3jcjm 258 21 factor factor NN cord-265139-x7g3jcjm 258 22 that that WDT cord-265139-x7g3jcjm 258 23 directly directly RB cord-265139-x7g3jcjm 258 24 interacts interact VBZ cord-265139-x7g3jcjm 258 25 with with IN cord-265139-x7g3jcjm 258 26 adipocyte adipocyte NN cord-265139-x7g3jcjm 258 27 RNAs rna NNS cord-265139-x7g3jcjm 258 28 and and CC cord-265139-x7g3jcjm 258 29 promotes promote VBZ cord-265139-x7g3jcjm 258 30 their -PRON- PRP$ cord-265139-x7g3jcjm 258 31 export export NN cord-265139-x7g3jcjm 258 32 from from IN cord-265139-x7g3jcjm 258 33 the the DT cord-265139-x7g3jcjm 258 34 nucleus nucleus NN cord-265139-x7g3jcjm 258 35 to to IN cord-265139-x7g3jcjm 258 36 the the DT cord-265139-x7g3jcjm 258 37 cytosol cytosol NN cord-265139-x7g3jcjm 258 38 [ [ -LRB- cord-265139-x7g3jcjm 258 39 121 121 CD cord-265139-x7g3jcjm 258 40 ] ] -RRB- cord-265139-x7g3jcjm 258 41 . . . cord-265139-x7g3jcjm 259 1 KH kh NN cord-265139-x7g3jcjm 259 2 - - HYPH cord-265139-x7g3jcjm 259 3 type type NN cord-265139-x7g3jcjm 259 4 splicing splicing NN cord-265139-x7g3jcjm 259 5 regulatory regulatory JJ cord-265139-x7g3jcjm 259 6 protein protein NN cord-265139-x7g3jcjm 259 7 ( ( -LRB- cord-265139-x7g3jcjm 259 8 KSRP KSRP NNP cord-265139-x7g3jcjm 259 9 ) ) -RRB- cord-265139-x7g3jcjm 260 1 targeted target VBN cord-265139-x7g3jcjm 260 2 deletion deletion NN cord-265139-x7g3jcjm 260 3 has have VBZ cord-265139-x7g3jcjm 260 4 been be VBN cord-265139-x7g3jcjm 260 5 shown show VBN cord-265139-x7g3jcjm 260 6 to to TO cord-265139-x7g3jcjm 260 7 promote promote VB cord-265139-x7g3jcjm 260 8 browning browning NN cord-265139-x7g3jcjm 260 9 of of IN cord-265139-x7g3jcjm 260 10 WAT WAT NNP cord-265139-x7g3jcjm 260 11 through through IN cord-265139-x7g3jcjm 260 12 reduction reduction NN cord-265139-x7g3jcjm 260 13 in in IN cord-265139-x7g3jcjm 260 14 miR-150 mir-150 NN cord-265139-x7g3jcjm 260 15 expression expression NN cord-265139-x7g3jcjm 260 16 [ [ -LRB- cord-265139-x7g3jcjm 260 17 122 122 CD cord-265139-x7g3jcjm 260 18 ] ] -RRB- cord-265139-x7g3jcjm 260 19 . . . cord-265139-x7g3jcjm 261 1 RNA rna NN cord-265139-x7g3jcjm 261 2 - - HYPH cord-265139-x7g3jcjm 261 3 binding bind VBG cord-265139-x7g3jcjm 261 4 protein protein NN cord-265139-x7g3jcjm 261 5 insulin insulin NN cord-265139-x7g3jcjm 261 6 growth growth NN cord-265139-x7g3jcjm 261 7 factor factor NN cord-265139-x7g3jcjm 261 8 2 2 CD cord-265139-x7g3jcjm 261 9 mRNA mrna NN cord-265139-x7g3jcjm 261 10 - - HYPH cord-265139-x7g3jcjm 261 11 binding bind VBG cord-265139-x7g3jcjm 261 12 protein protein NN cord-265139-x7g3jcjm 261 13 2 2 CD cord-265139-x7g3jcjm 262 1 ( ( -LRB- cord-265139-x7g3jcjm 262 2 IMP2 IMP2 NNP cord-265139-x7g3jcjm 262 3 ) ) -RRB- cord-265139-x7g3jcjm 262 4 controls control VBZ cord-265139-x7g3jcjm 262 5 energy energy NN cord-265139-x7g3jcjm 262 6 metabolism metabolism NN cord-265139-x7g3jcjm 262 7 by by IN cord-265139-x7g3jcjm 262 8 suppressing suppress VBG cord-265139-x7g3jcjm 262 9 mRNA mRNA NNP cord-265139-x7g3jcjm 262 10 translation translation NN cord-265139-x7g3jcjm 262 11 of of IN cord-265139-x7g3jcjm 262 12 mitochondrial mitochondrial JJ cord-265139-x7g3jcjm 262 13 proton proton NN cord-265139-x7g3jcjm 262 14 transporter transporter NN cord-265139-x7g3jcjm 262 15 uncoupling uncouple VBG cord-265139-x7g3jcjm 262 16 protein protein NN cord-265139-x7g3jcjm 262 17 1 1 CD cord-265139-x7g3jcjm 262 18 ( ( -LRB- cord-265139-x7g3jcjm 262 19 UCP1 UCP1 NNP cord-265139-x7g3jcjm 262 20 ) ) -RRB- cord-265139-x7g3jcjm 262 21 and and CC cord-265139-x7g3jcjm 262 22 other other JJ cord-265139-x7g3jcjm 262 23 mitochondrial mitochondrial NN cord-265139-x7g3jcjm 263 1 mRNAs mRNAs `` cord-265139-x7g3jcjm 263 2 in in IN cord-265139-x7g3jcjm 263 3 BAT bat NN cord-265139-x7g3jcjm 263 4 [ [ -LRB- cord-265139-x7g3jcjm 263 5 123 123 CD cord-265139-x7g3jcjm 263 6 ] ] -RRB- cord-265139-x7g3jcjm 263 7 . . . cord-265139-x7g3jcjm 264 1 More more RBR cord-265139-x7g3jcjm 264 2 interesting interesting JJ cord-265139-x7g3jcjm 264 3 , , , cord-265139-x7g3jcjm 264 4 two two CD cord-265139-x7g3jcjm 264 5 recently recently RB cord-265139-x7g3jcjm 264 6 published publish VBN cord-265139-x7g3jcjm 264 7 studies study NNS cord-265139-x7g3jcjm 264 8 reported report VBD cord-265139-x7g3jcjm 264 9 that that IN cord-265139-x7g3jcjm 264 10 the the DT cord-265139-x7g3jcjm 264 11 RNA RNA NNP cord-265139-x7g3jcjm 264 12 - - HYPH cord-265139-x7g3jcjm 264 13 binding bind VBG cord-265139-x7g3jcjm 264 14 protein protein NN cord-265139-x7g3jcjm 264 15 HuR hur NN cord-265139-x7g3jcjm 264 16 protects protect VBZ cord-265139-x7g3jcjm 264 17 against against IN cord-265139-x7g3jcjm 264 18 obesity obesity NN cord-265139-x7g3jcjm 264 19 and and CC cord-265139-x7g3jcjm 264 20 IR IR NNP cord-265139-x7g3jcjm 264 21 [ [ -LRB- cord-265139-x7g3jcjm 264 22 124 124 CD cord-265139-x7g3jcjm 264 23 , , , cord-265139-x7g3jcjm 264 24 125 125 CD cord-265139-x7g3jcjm 264 25 ] ] -RRB- cord-265139-x7g3jcjm 264 26 . . . cord-265139-x7g3jcjm 265 1 However however RB cord-265139-x7g3jcjm 265 2 , , , cord-265139-x7g3jcjm 265 3 it -PRON- PRP cord-265139-x7g3jcjm 265 4 remains remain VBZ cord-265139-x7g3jcjm 265 5 unclear unclear JJ cord-265139-x7g3jcjm 265 6 as as IN cord-265139-x7g3jcjm 265 7 to to IN cord-265139-x7g3jcjm 265 8 whether whether IN cord-265139-x7g3jcjm 265 9 this this DT cord-265139-x7g3jcjm 265 10 mechanism mechanism NN cord-265139-x7g3jcjm 265 11 involves involve VBZ cord-265139-x7g3jcjm 265 12 an an DT cord-265139-x7g3jcjm 265 13 interaction interaction NN cord-265139-x7g3jcjm 265 14 with with IN cord-265139-x7g3jcjm 265 15 circRNAs circrna NNS cord-265139-x7g3jcjm 265 16 or or CC cord-265139-x7g3jcjm 265 17 not not RB cord-265139-x7g3jcjm 265 18 . . . cord-265139-x7g3jcjm 266 1 As as IN cord-265139-x7g3jcjm 266 2 stated state VBN cord-265139-x7g3jcjm 266 3 before before RB cord-265139-x7g3jcjm 266 4 , , , cord-265139-x7g3jcjm 266 5 circRNAs circRNAs NNP cord-265139-x7g3jcjm 266 6 containing contain VBG cord-265139-x7g3jcjm 266 7 RBP rbp NN cord-265139-x7g3jcjm 266 8 binding bind VBG cord-265139-x7g3jcjm 266 9 sites site NNS cord-265139-x7g3jcjm 266 10 may may MD cord-265139-x7g3jcjm 266 11 serve serve VB cord-265139-x7g3jcjm 266 12 as as IN cord-265139-x7g3jcjm 266 13 sponges sponge NNS cord-265139-x7g3jcjm 266 14 or or CC cord-265139-x7g3jcjm 266 15 decoys decoy NNS cord-265139-x7g3jcjm 266 16 for for IN cord-265139-x7g3jcjm 266 17 these these DT cord-265139-x7g3jcjm 266 18 proteins protein NNS cord-265139-x7g3jcjm 266 19 and and CC cord-265139-x7g3jcjm 266 20 are be VBP cord-265139-x7g3jcjm 266 21 thus thus RB cord-265139-x7g3jcjm 266 22 predicted predict VBN cord-265139-x7g3jcjm 266 23 to to TO cord-265139-x7g3jcjm 266 24 function function VB cord-265139-x7g3jcjm 266 25 as as IN cord-265139-x7g3jcjm 266 26 robust robust JJ cord-265139-x7g3jcjm 266 27 posttranscriptional posttranscriptional JJ cord-265139-x7g3jcjm 266 28 regulators regulator NNS cord-265139-x7g3jcjm 266 29 of of IN cord-265139-x7g3jcjm 266 30 gene gene NN cord-265139-x7g3jcjm 266 31 expression expression NN cord-265139-x7g3jcjm 266 32 . . . cord-265139-x7g3jcjm 267 1 Unfortunately unfortunately RB cord-265139-x7g3jcjm 267 2 , , , cord-265139-x7g3jcjm 267 3 the the DT cord-265139-x7g3jcjm 267 4 biochemical biochemical JJ cord-265139-x7g3jcjm 267 5 stoichiometry stoichiometry NN cord-265139-x7g3jcjm 267 6 between between IN cord-265139-x7g3jcjm 267 7 circRNAs circrna NNS cord-265139-x7g3jcjm 267 8 - - HYPH cord-265139-x7g3jcjm 267 9 miRNAs mirnas JJ cord-265139-x7g3jcjm 267 10 and and CC cord-265139-x7g3jcjm 267 11 circRNAs circrna NNS cord-265139-x7g3jcjm 267 12 - - HYPH cord-265139-x7g3jcjm 267 13 RBPs rbps NN cord-265139-x7g3jcjm 267 14 is be VBZ cord-265139-x7g3jcjm 267 15 not not RB cord-265139-x7g3jcjm 267 16 yet yet RB cord-265139-x7g3jcjm 267 17 well well RB cord-265139-x7g3jcjm 267 18 determined determined JJ cord-265139-x7g3jcjm 267 19 in in IN cord-265139-x7g3jcjm 267 20 adipose adipose JJ cord-265139-x7g3jcjm 267 21 tissue tissue NN cord-265139-x7g3jcjm 267 22 . . . cord-265139-x7g3jcjm 268 1 The the DT cord-265139-x7g3jcjm 268 2 relative relative JJ cord-265139-x7g3jcjm 268 3 abundance abundance NN cord-265139-x7g3jcjm 268 4 of of IN cord-265139-x7g3jcjm 268 5 circRNAs circrna NNS cord-265139-x7g3jcjm 268 6 , , , cord-265139-x7g3jcjm 268 7 miRNAs miRNAs NNP cord-265139-x7g3jcjm 268 8 , , , cord-265139-x7g3jcjm 268 9 and and CC cord-265139-x7g3jcjm 268 10 RBPs RBPs NNP cord-265139-x7g3jcjm 268 11 as as RB cord-265139-x7g3jcjm 268 12 well well RB cord-265139-x7g3jcjm 268 13 as as IN cord-265139-x7g3jcjm 268 14 their -PRON- PRP$ cord-265139-x7g3jcjm 268 15 epigenetics epigenetics NN cord-265139-x7g3jcjm 268 16 modifications modification NNS cord-265139-x7g3jcjm 268 17 ( ( -LRB- cord-265139-x7g3jcjm 268 18 e.g. e.g. RB cord-265139-x7g3jcjm 268 19 , , , cord-265139-x7g3jcjm 268 20 hypermethylation hypermethylation NN cord-265139-x7g3jcjm 268 21 ) ) -RRB- cord-265139-x7g3jcjm 268 22 and and CC cord-265139-x7g3jcjm 268 23 stoichiometry stoichiometry NN cord-265139-x7g3jcjm 268 24 analysis analysis NN cord-265139-x7g3jcjm 268 25 must must MD cord-265139-x7g3jcjm 268 26 be be VB cord-265139-x7g3jcjm 268 27 considered consider VBN cord-265139-x7g3jcjm 268 28 for for IN cord-265139-x7g3jcjm 268 29 the the DT cord-265139-x7g3jcjm 268 30 physiological physiological JJ cord-265139-x7g3jcjm 268 31 relevance relevance NN cord-265139-x7g3jcjm 268 32 of of IN cord-265139-x7g3jcjm 268 33 any any DT cord-265139-x7g3jcjm 268 34 sequestration sequestration NN cord-265139-x7g3jcjm 268 35 effect effect NN cord-265139-x7g3jcjm 268 36 and and CC cord-265139-x7g3jcjm 268 37 cross cross NN cord-265139-x7g3jcjm 268 38 - - NN cord-265139-x7g3jcjm 268 39 regulation regulation NN cord-265139-x7g3jcjm 268 40 as as IN cord-265139-x7g3jcjm 268 41 it -PRON- PRP cord-265139-x7g3jcjm 268 42 may may MD cord-265139-x7g3jcjm 268 43 support support VB cord-265139-x7g3jcjm 268 44 the the DT cord-265139-x7g3jcjm 268 45 concept concept NN cord-265139-x7g3jcjm 268 46 that that WDT cord-265139-x7g3jcjm 268 47 circRNAs circrna NNS cord-265139-x7g3jcjm 268 48 can can MD cord-265139-x7g3jcjm 268 49 serve serve VB cord-265139-x7g3jcjm 268 50 as as IN cord-265139-x7g3jcjm 268 51 protein protein NN cord-265139-x7g3jcjm 268 52 sponges sponge NNS cord-265139-x7g3jcjm 268 53 or or CC cord-265139-x7g3jcjm 268 54 decoys decoy NNS cord-265139-x7g3jcjm 268 55 to to TO cord-265139-x7g3jcjm 268 56 influence influence VB cord-265139-x7g3jcjm 268 57 their -PRON- PRP$ cord-265139-x7g3jcjm 268 58 cellular cellular JJ cord-265139-x7g3jcjm 268 59 functions function NNS cord-265139-x7g3jcjm 268 60 . . . cord-265139-x7g3jcjm 269 1 Nevertheless nevertheless RB cord-265139-x7g3jcjm 269 2 , , , cord-265139-x7g3jcjm 269 3 regardless regardless RB cord-265139-x7g3jcjm 269 4 of of IN cord-265139-x7g3jcjm 269 5 their -PRON- PRP$ cord-265139-x7g3jcjm 269 6 function function NN cord-265139-x7g3jcjm 269 7 , , , cord-265139-x7g3jcjm 269 8 the the DT cord-265139-x7g3jcjm 269 9 potential potential JJ cord-265139-x7g3jcjm 269 10 use use NN cord-265139-x7g3jcjm 269 11 of of IN cord-265139-x7g3jcjm 269 12 circRNAs circrna NNS cord-265139-x7g3jcjm 269 13 as as IN cord-265139-x7g3jcjm 269 14 biomarkers biomarker NNS cord-265139-x7g3jcjm 269 15 for for IN cord-265139-x7g3jcjm 269 16 obesity obesity NN cord-265139-x7g3jcjm 269 17 and and CC cord-265139-x7g3jcjm 269 18 metabolic metabolic JJ cord-265139-x7g3jcjm 269 19 diseases disease NNS cord-265139-x7g3jcjm 269 20 remains remain VBZ cord-265139-x7g3jcjm 269 21 a a DT cord-265139-x7g3jcjm 269 22 great great JJ cord-265139-x7g3jcjm 269 23 promise promise NN cord-265139-x7g3jcjm 269 24 . . . cord-265139-x7g3jcjm 270 1 iv iv LS cord-265139-x7g3jcjm 270 2 ) ) -RRB- cord-265139-x7g3jcjm 271 1 Although although IN cord-265139-x7g3jcjm 271 2 the the DT cord-265139-x7g3jcjm 271 3 existing exist VBG cord-265139-x7g3jcjm 271 4 studies study NNS cord-265139-x7g3jcjm 271 5 support support VBP cord-265139-x7g3jcjm 271 6 the the DT cord-265139-x7g3jcjm 271 7 potential potential JJ cord-265139-x7g3jcjm 271 8 value value NN cord-265139-x7g3jcjm 271 9 of of IN cord-265139-x7g3jcjm 271 10 circRNAs circrna NNS cord-265139-x7g3jcjm 271 11 in in IN cord-265139-x7g3jcjm 271 12 the the DT cord-265139-x7g3jcjm 271 13 diagnosis diagnosis NN cord-265139-x7g3jcjm 271 14 and and CC cord-265139-x7g3jcjm 271 15 therapeutics therapeutic NNS cord-265139-x7g3jcjm 271 16 of of IN cord-265139-x7g3jcjm 271 17 obesity obesity NN cord-265139-x7g3jcjm 271 18 , , , cord-265139-x7g3jcjm 271 19 it -PRON- PRP cord-265139-x7g3jcjm 271 20 is be VBZ cord-265139-x7g3jcjm 271 21 too too RB cord-265139-x7g3jcjm 271 22 early early JJ cord-265139-x7g3jcjm 271 23 to to TO cord-265139-x7g3jcjm 271 24 consider consider VB cord-265139-x7g3jcjm 271 25 the the DT cord-265139-x7g3jcjm 271 26 feasibility feasibility NN cord-265139-x7g3jcjm 271 27 of of IN cord-265139-x7g3jcjm 271 28 these these DT cord-265139-x7g3jcjm 271 29 molecules molecule NNS cord-265139-x7g3jcjm 271 30 as as IN cord-265139-x7g3jcjm 271 31 biomarkers biomarker NNS cord-265139-x7g3jcjm 271 32 and and CC cord-265139-x7g3jcjm 271 33 disease disease NN cord-265139-x7g3jcjm 271 34 therapeutic therapeutic JJ cord-265139-x7g3jcjm 271 35 targets target NNS cord-265139-x7g3jcjm 271 36 in in IN cord-265139-x7g3jcjm 271 37 a a DT cord-265139-x7g3jcjm 271 38 clinical clinical JJ cord-265139-x7g3jcjm 271 39 obesity obesity NN cord-265139-x7g3jcjm 271 40 setting setting NN cord-265139-x7g3jcjm 271 41 . . . cord-265139-x7g3jcjm 272 1 As as IN cord-265139-x7g3jcjm 272 2 of of IN cord-265139-x7g3jcjm 272 3 now now RB cord-265139-x7g3jcjm 272 4 , , , cord-265139-x7g3jcjm 272 5 the the DT cord-265139-x7g3jcjm 272 6 effectiveness effectiveness NN cord-265139-x7g3jcjm 272 7 of of IN cord-265139-x7g3jcjm 272 8 circRNAs circRNAs NNP cord-265139-x7g3jcjm 272 9 has have VBZ cord-265139-x7g3jcjm 272 10 not not RB cord-265139-x7g3jcjm 272 11 been be VBN cord-265139-x7g3jcjm 272 12 explored explore VBN cord-265139-x7g3jcjm 272 13 in in IN cord-265139-x7g3jcjm 272 14 large large JJ cord-265139-x7g3jcjm 272 15 , , , cord-265139-x7g3jcjm 272 16 clinically clinically RB cord-265139-x7g3jcjm 272 17 controlled control VBN cord-265139-x7g3jcjm 272 18 , , , cord-265139-x7g3jcjm 272 19 and and CC cord-265139-x7g3jcjm 272 20 conclusive conclusive JJ cord-265139-x7g3jcjm 272 21 cohorts cohort NNS cord-265139-x7g3jcjm 272 22 , , , cord-265139-x7g3jcjm 272 23 nor nor CC cord-265139-x7g3jcjm 272 24 their -PRON- PRP$ cord-265139-x7g3jcjm 272 25 mechanisms mechanism NNS cord-265139-x7g3jcjm 272 26 of of IN cord-265139-x7g3jcjm 272 27 action action NN cord-265139-x7g3jcjm 272 28 extensively extensively RB cord-265139-x7g3jcjm 272 29 studied study VBD cord-265139-x7g3jcjm 272 30 . . . cord-265139-x7g3jcjm 273 1 In in IN cord-265139-x7g3jcjm 273 2 addition addition NN cord-265139-x7g3jcjm 273 3 , , , cord-265139-x7g3jcjm 273 4 potential potential JJ cord-265139-x7g3jcjm 273 5 toxicity toxicity NN cord-265139-x7g3jcjm 273 6 , , , cord-265139-x7g3jcjm 273 7 reaction reaction NN cord-265139-x7g3jcjm 273 8 to to IN cord-265139-x7g3jcjm 273 9 drugs drug NNS cord-265139-x7g3jcjm 273 10 , , , cord-265139-x7g3jcjm 273 11 immune immune JJ cord-265139-x7g3jcjm 273 12 response response NN cord-265139-x7g3jcjm 273 13 , , , cord-265139-x7g3jcjm 273 14 accumulation accumulation NN cord-265139-x7g3jcjm 273 15 to to IN cord-265139-x7g3jcjm 273 16 other other JJ cord-265139-x7g3jcjm 273 17 tissues tissue NNS cord-265139-x7g3jcjm 273 18 , , , cord-265139-x7g3jcjm 273 19 and and CC cord-265139-x7g3jcjm 273 20 adequate adequate JJ cord-265139-x7g3jcjm 273 21 carriers carrier NNS cord-265139-x7g3jcjm 273 22 of of IN cord-265139-x7g3jcjm 273 23 circRNAs circrna NNS cord-265139-x7g3jcjm 273 24 remain remain VBP cord-265139-x7g3jcjm 273 25 unknown unknown JJ cord-265139-x7g3jcjm 273 26 . . . cord-265139-x7g3jcjm 274 1 Nevertheless nevertheless RB cord-265139-x7g3jcjm 274 2 , , , cord-265139-x7g3jcjm 274 3 a a DT cord-265139-x7g3jcjm 274 4 greater great JJR cord-265139-x7g3jcjm 274 5 understanding understanding NN cord-265139-x7g3jcjm 274 6 of of IN cord-265139-x7g3jcjm 274 7 these these DT cord-265139-x7g3jcjm 274 8 issues issue NNS cord-265139-x7g3jcjm 274 9 is be VBZ cord-265139-x7g3jcjm 274 10 required require VBN cord-265139-x7g3jcjm 274 11 if if IN cord-265139-x7g3jcjm 274 12 we -PRON- PRP cord-265139-x7g3jcjm 274 13 are be VBP cord-265139-x7g3jcjm 274 14 to to TO cord-265139-x7g3jcjm 274 15 see see VB cord-265139-x7g3jcjm 274 16 circRNAs circrnas JJ cord-265139-x7g3jcjm 274 17 clinical clinical JJ cord-265139-x7g3jcjm 274 18 translation translation NN cord-265139-x7g3jcjm 274 19 becoming become VBG cord-265139-x7g3jcjm 274 20 a a DT cord-265139-x7g3jcjm 274 21 reality reality NN cord-265139-x7g3jcjm 274 22 . . . cord-265139-x7g3jcjm 275 1 v v LS cord-265139-x7g3jcjm 275 2 ) ) -RRB- cord-265139-x7g3jcjm 275 3 Since since IN cord-265139-x7g3jcjm 275 4 obesity obesity NN cord-265139-x7g3jcjm 275 5 is be VBZ cord-265139-x7g3jcjm 275 6 a a DT cord-265139-x7g3jcjm 275 7 context context NN cord-265139-x7g3jcjm 275 8 of of IN cord-265139-x7g3jcjm 275 9 metabolic metabolic JJ cord-265139-x7g3jcjm 275 10 stress stress NN cord-265139-x7g3jcjm 275 11 associated associate VBN cord-265139-x7g3jcjm 275 12 with with IN cord-265139-x7g3jcjm 275 13 dysfunction dysfunction NN cord-265139-x7g3jcjm 275 14 of of IN cord-265139-x7g3jcjm 275 15 numerous numerous JJ cord-265139-x7g3jcjm 275 16 biological biological JJ cord-265139-x7g3jcjm 275 17 processes process NNS cord-265139-x7g3jcjm 275 18 including include VBG cord-265139-x7g3jcjm 275 19 adipose adipose JJ cord-265139-x7g3jcjm 275 20 tissue tissue NN cord-265139-x7g3jcjm 275 21 dynamic dynamic JJ cord-265139-x7g3jcjm 275 22 , , , cord-265139-x7g3jcjm 275 23 lipid lipid NN cord-265139-x7g3jcjm 275 24 metabolism metabolism NN cord-265139-x7g3jcjm 275 25 , , , cord-265139-x7g3jcjm 275 26 insulin insulin NN cord-265139-x7g3jcjm 275 27 signaling signal VBG cord-265139-x7g3jcjm 275 28 pathways pathway NNS cord-265139-x7g3jcjm 275 29 , , , cord-265139-x7g3jcjm 275 30 adipokines adipokine NNS cord-265139-x7g3jcjm 275 31 secretion secretion NN cord-265139-x7g3jcjm 275 32 , , , cord-265139-x7g3jcjm 275 33 systemic systemic JJ cord-265139-x7g3jcjm 275 34 inflammation inflammation NN cord-265139-x7g3jcjm 275 35 , , , cord-265139-x7g3jcjm 275 36 and and CC cord-265139-x7g3jcjm 275 37 mitochondrial mitochondrial JJ cord-265139-x7g3jcjm 275 38 activities activity NNS cord-265139-x7g3jcjm 275 39 , , , cord-265139-x7g3jcjm 275 40 it -PRON- PRP cord-265139-x7g3jcjm 275 41 is be VBZ cord-265139-x7g3jcjm 275 42 not not RB cord-265139-x7g3jcjm 275 43 clear clear JJ cord-265139-x7g3jcjm 275 44 how how WRB cord-265139-x7g3jcjm 275 45 all all PDT cord-265139-x7g3jcjm 275 46 these these DT cord-265139-x7g3jcjm 275 47 parameters parameter NNS cord-265139-x7g3jcjm 275 48 might may MD cord-265139-x7g3jcjm 275 49 affect affect VB cord-265139-x7g3jcjm 275 50 the the DT cord-265139-x7g3jcjm 275 51 machinery machinery NN cord-265139-x7g3jcjm 275 52 of of IN cord-265139-x7g3jcjm 275 53 circRNAs circrnas JJ cord-265139-x7g3jcjm 275 54 biogenesis biogenesis NN cord-265139-x7g3jcjm 275 55 , , , cord-265139-x7g3jcjm 275 56 secretion secretion NN cord-265139-x7g3jcjm 275 57 , , , cord-265139-x7g3jcjm 275 58 transfer transfer NN cord-265139-x7g3jcjm 275 59 , , , cord-265139-x7g3jcjm 275 60 and and CC cord-265139-x7g3jcjm 275 61 mode mode NN cord-265139-x7g3jcjm 275 62 of of IN cord-265139-x7g3jcjm 275 63 action action NN cord-265139-x7g3jcjm 275 64 . . . cord-265139-x7g3jcjm 276 1 vi vi NNP cord-265139-x7g3jcjm 276 2 ) ) -RRB- cord-265139-x7g3jcjm 277 1 Last last JJ cord-265139-x7g3jcjm 277 2 but but CC cord-265139-x7g3jcjm 277 3 not not RB cord-265139-x7g3jcjm 277 4 least least JJS cord-265139-x7g3jcjm 277 5 , , , cord-265139-x7g3jcjm 277 6 given give VBN cord-265139-x7g3jcjm 277 7 the the DT cord-265139-x7g3jcjm 277 8 complexity complexity NN cord-265139-x7g3jcjm 277 9 of of IN cord-265139-x7g3jcjm 277 10 obesity obesity NN cord-265139-x7g3jcjm 277 11 pathomechanisms pathomechanism NNS cord-265139-x7g3jcjm 277 12 , , , cord-265139-x7g3jcjm 277 13 relying rely VBG cord-265139-x7g3jcjm 277 14 on on IN cord-265139-x7g3jcjm 277 15 the the DT cord-265139-x7g3jcjm 277 16 pattern pattern NN cord-265139-x7g3jcjm 277 17 of of IN cord-265139-x7g3jcjm 277 18 a a DT cord-265139-x7g3jcjm 277 19 single single JJ cord-265139-x7g3jcjm 277 20 circRNA circrna NN cord-265139-x7g3jcjm 277 21 for for IN cord-265139-x7g3jcjm 277 22 diagnosis diagnosis NN cord-265139-x7g3jcjm 277 23 and and CC cord-265139-x7g3jcjm 277 24 treatment treatment NN cord-265139-x7g3jcjm 277 25 obesity obesity NN cord-265139-x7g3jcjm 277 26 may may MD cord-265139-x7g3jcjm 277 27 not not RB cord-265139-x7g3jcjm 277 28 be be VB cord-265139-x7g3jcjm 277 29 biologically biologically RB cord-265139-x7g3jcjm 277 30 most most RBS cord-265139-x7g3jcjm 277 31 relevant relevant JJ cord-265139-x7g3jcjm 277 32 and and CC cord-265139-x7g3jcjm 277 33 sufficiently sufficiently RB cord-265139-x7g3jcjm 277 34 specific specific JJ cord-265139-x7g3jcjm 277 35 to to TO cord-265139-x7g3jcjm 277 36 provide provide VB cord-265139-x7g3jcjm 277 37 a a DT cord-265139-x7g3jcjm 277 38 clinical clinical JJ cord-265139-x7g3jcjm 277 39 utility utility NN cord-265139-x7g3jcjm 277 40 . . . cord-265139-x7g3jcjm 278 1 Rather rather RB cord-265139-x7g3jcjm 278 2 , , , cord-265139-x7g3jcjm 278 3 one one PRP cord-265139-x7g3jcjm 278 4 should should MD cord-265139-x7g3jcjm 278 5 consider consider VB cord-265139-x7g3jcjm 278 6 a a DT cord-265139-x7g3jcjm 278 7 multi multi JJ cord-265139-x7g3jcjm 278 8 - - NNS cord-265139-x7g3jcjm 278 9 markers marker NNS cord-265139-x7g3jcjm 278 10 approach approach NN cord-265139-x7g3jcjm 278 11 that that WDT cord-265139-x7g3jcjm 278 12 combines combine VBZ cord-265139-x7g3jcjm 278 13 candidate candidate NN cord-265139-x7g3jcjm 278 14 circRNAs circrna NNS cord-265139-x7g3jcjm 278 15 / / SYM cord-265139-x7g3jcjm 278 16 signatures signature NNS cord-265139-x7g3jcjm 278 17 , , , cord-265139-x7g3jcjm 278 18 miRNAs miRNAs NNP cord-265139-x7g3jcjm 278 19 , , , cord-265139-x7g3jcjm 278 20 and and CC cord-265139-x7g3jcjm 278 21 RBPs RBPs NNP cord-265139-x7g3jcjm 278 22 which which WDT cord-265139-x7g3jcjm 278 23 may may MD cord-265139-x7g3jcjm 278 24 be be VB cord-265139-x7g3jcjm 278 25 highly highly RB cord-265139-x7g3jcjm 278 26 discriminative discriminative JJ cord-265139-x7g3jcjm 278 27 , , , cord-265139-x7g3jcjm 278 28 accurate accurate JJ cord-265139-x7g3jcjm 278 29 , , , cord-265139-x7g3jcjm 278 30 and and CC cord-265139-x7g3jcjm 278 31 efficient efficient JJ cord-265139-x7g3jcjm 278 32 in in IN cord-265139-x7g3jcjm 278 33 predicting predict VBG cord-265139-x7g3jcjm 278 34 obesity obesity NN cord-265139-x7g3jcjm 278 35 and and CC cord-265139-x7g3jcjm 278 36 associated associate VBN cord-265139-x7g3jcjm 278 37 metabolic metabolic JJ cord-265139-x7g3jcjm 278 38 perturbations perturbation NNS cord-265139-x7g3jcjm 278 39 . . . cord-265139-x7g3jcjm 279 1 To to TO cord-265139-x7g3jcjm 279 2 sum sum VB cord-265139-x7g3jcjm 279 3 up up RP cord-265139-x7g3jcjm 279 4 , , , cord-265139-x7g3jcjm 279 5 circRNAs circrna NNS cord-265139-x7g3jcjm 279 6 have have VBP cord-265139-x7g3jcjm 279 7 recently recently RB cord-265139-x7g3jcjm 279 8 emerged emerge VBN cord-265139-x7g3jcjm 279 9 as as IN cord-265139-x7g3jcjm 279 10 a a DT cord-265139-x7g3jcjm 279 11 class class NN cord-265139-x7g3jcjm 279 12 of of IN cord-265139-x7g3jcjm 279 13 ncRNAs ncRNAs NNP cord-265139-x7g3jcjm 279 14 with with IN cord-265139-x7g3jcjm 279 15 multifaceted multifaceted JJ cord-265139-x7g3jcjm 279 16 roles role NNS cord-265139-x7g3jcjm 279 17 in in IN cord-265139-x7g3jcjm 279 18 the the DT cord-265139-x7g3jcjm 279 19 cell cell NN cord-265139-x7g3jcjm 279 20 . . . cord-265139-x7g3jcjm 280 1 Emerging emerge VBG cord-265139-x7g3jcjm 280 2 evidence evidence NN cord-265139-x7g3jcjm 280 3 from from IN cord-265139-x7g3jcjm 280 4 in in IN cord-265139-x7g3jcjm 280 5 vitro vitro FW cord-265139-x7g3jcjm 280 6 and and CC cord-265139-x7g3jcjm 280 7 in in IN cord-265139-x7g3jcjm 280 8 vivo vivo NNP cord-265139-x7g3jcjm 280 9 experimental experimental JJ cord-265139-x7g3jcjm 280 10 studies study NNS cord-265139-x7g3jcjm 280 11 indicates indicate VBZ cord-265139-x7g3jcjm 280 12 that that IN cord-265139-x7g3jcjm 280 13 circRNAs circrna NNS cord-265139-x7g3jcjm 280 14 are be VBP cord-265139-x7g3jcjm 280 15 involved involve VBN cord-265139-x7g3jcjm 280 16 in in IN cord-265139-x7g3jcjm 280 17 the the DT cord-265139-x7g3jcjm 280 18 regulation regulation NN cord-265139-x7g3jcjm 280 19 of of IN cord-265139-x7g3jcjm 280 20 adipogenesis adipogenesis NN cord-265139-x7g3jcjm 280 21 and and CC cord-265139-x7g3jcjm 280 22 obesity obesity NN cord-265139-x7g3jcjm 280 23 . . . cord-265139-x7g3jcjm 281 1 However however RB cord-265139-x7g3jcjm 281 2 , , , cord-265139-x7g3jcjm 281 3 the the DT cord-265139-x7g3jcjm 281 4 ongoing ongoing JJ cord-265139-x7g3jcjm 281 5 efforts effort NNS cord-265139-x7g3jcjm 281 6 to to TO cord-265139-x7g3jcjm 281 7 better better RB cord-265139-x7g3jcjm 281 8 understand understand VB cord-265139-x7g3jcjm 281 9 the the DT cord-265139-x7g3jcjm 281 10 role role NN cord-265139-x7g3jcjm 281 11 of of IN cord-265139-x7g3jcjm 281 12 circRNAs circrna NNS cord-265139-x7g3jcjm 281 13 in in IN cord-265139-x7g3jcjm 281 14 adipose adipose JJ cord-265139-x7g3jcjm 281 15 tissue tissue NN cord-265139-x7g3jcjm 281 16 and and CC cord-265139-x7g3jcjm 281 17 metabolics metabolic NNS cord-265139-x7g3jcjm 281 18 must must MD cord-265139-x7g3jcjm 281 19 include include VB cord-265139-x7g3jcjm 281 20 the the DT cord-265139-x7g3jcjm 281 21 above above RB cord-265139-x7g3jcjm 281 22 - - HYPH cord-265139-x7g3jcjm 281 23 mentioned mention VBN cord-265139-x7g3jcjm 281 24 considerations consideration NNS cord-265139-x7g3jcjm 281 25 as as IN cord-265139-x7g3jcjm 281 26 they -PRON- PRP cord-265139-x7g3jcjm 281 27 may may MD cord-265139-x7g3jcjm 281 28 help help VB cord-265139-x7g3jcjm 281 29 accelerate accelerate VB cord-265139-x7g3jcjm 281 30 their -PRON- PRP$ cord-265139-x7g3jcjm 281 31 clinical clinical JJ cord-265139-x7g3jcjm 281 32 research research NN cord-265139-x7g3jcjm 281 33 . . . cord-265139-x7g3jcjm 282 1 Funding funding NN cord-265139-x7g3jcjm 282 2 : : : cord-265139-x7g3jcjm 283 1 No no DT cord-265139-x7g3jcjm 283 2 funding funding NN cord-265139-x7g3jcjm 283 3 was be VBD cord-265139-x7g3jcjm 283 4 received receive VBN cord-265139-x7g3jcjm 283 5 for for IN cord-265139-x7g3jcjm 283 6 this this DT cord-265139-x7g3jcjm 283 7 article article NN cord-265139-x7g3jcjm 283 8 . . . cord-265139-x7g3jcjm 284 1 The the DT cord-265139-x7g3jcjm 284 2 author author NN cord-265139-x7g3jcjm 284 3 declares declare VBZ cord-265139-x7g3jcjm 284 4 no no DT cord-265139-x7g3jcjm 284 5 conflict conflict NN cord-265139-x7g3jcjm 284 6 of of IN cord-265139-x7g3jcjm 284 7 interest interest NN cord-265139-x7g3jcjm 284 8 . . . cord-265139-x7g3jcjm 285 1 Naming name VBG cord-265139-x7g3jcjm 285 2 ' ' `` cord-265139-x7g3jcjm 285 3 junk junk NN cord-265139-x7g3jcjm 285 4 ' ' '' cord-265139-x7g3jcjm 285 5 : : : cord-265139-x7g3jcjm 285 6 human human JJ cord-265139-x7g3jcjm 285 7 non non JJ cord-265139-x7g3jcjm 285 8 - - JJ cord-265139-x7g3jcjm 285 9 protein protein JJ cord-265139-x7g3jcjm 285 10 coding coding NN cord-265139-x7g3jcjm 285 11 RNA RNA NNP cord-265139-x7g3jcjm 285 12 ( ( -LRB- cord-265139-x7g3jcjm 285 13 ncRNA ncRNA NNS cord-265139-x7g3jcjm 285 14 ) ) -RRB- cord-265139-x7g3jcjm 285 15 gene gene NN cord-265139-x7g3jcjm 285 16 nomenclature nomenclature NN cord-265139-x7g3jcjm 286 1 Targeted target VBN cord-265139-x7g3jcjm 286 2 RNA RNA NNP cord-265139-x7g3jcjm 286 3 sequencing sequencing NN cord-265139-x7g3jcjm 286 4 reveals reveal VBZ cord-265139-x7g3jcjm 286 5 the the DT cord-265139-x7g3jcjm 286 6 deep deep JJ cord-265139-x7g3jcjm 286 7 complexity complexity NN cord-265139-x7g3jcjm 286 8 of of IN cord-265139-x7g3jcjm 286 9 the the DT cord-265139-x7g3jcjm 286 10 human human JJ cord-265139-x7g3jcjm 286 11 transcriptome transcriptome NN cord-265139-x7g3jcjm 286 12 Non Non NNP cord-265139-x7g3jcjm 286 13 - - NNP cord-265139-x7g3jcjm 286 14 coding code VBG cord-265139-x7g3jcjm 286 15 RNA RNA NNP cord-265139-x7g3jcjm 286 16 genes gene NNS cord-265139-x7g3jcjm 286 17 and and CC cord-265139-x7g3jcjm 286 18 the the DT cord-265139-x7g3jcjm 286 19 modern modern JJ cord-265139-x7g3jcjm 286 20 RNA RNA NNP cord-265139-x7g3jcjm 286 21 world world NN cord-265139-x7g3jcjm 287 1 The the DT cord-265139-x7g3jcjm 287 2 dark dark JJ cord-265139-x7g3jcjm 287 3 matter matter NN cord-265139-x7g3jcjm 287 4 of of IN cord-265139-x7g3jcjm 287 5 the the DT cord-265139-x7g3jcjm 287 6 cancer cancer NN cord-265139-x7g3jcjm 287 7 genome genome NN cord-265139-x7g3jcjm 287 8 : : : cord-265139-x7g3jcjm 287 9 aberrations aberration NNS cord-265139-x7g3jcjm 287 10 in in IN cord-265139-x7g3jcjm 287 11 regulatory regulatory JJ cord-265139-x7g3jcjm 287 12 elements element NNS cord-265139-x7g3jcjm 287 13 , , , cord-265139-x7g3jcjm 287 14 untranslated untranslated JJ cord-265139-x7g3jcjm 287 15 regions region NNS cord-265139-x7g3jcjm 287 16 , , , cord-265139-x7g3jcjm 287 17 splice splice NN cord-265139-x7g3jcjm 287 18 sites site NNS cord-265139-x7g3jcjm 287 19 , , , cord-265139-x7g3jcjm 287 20 non non JJ cord-265139-x7g3jcjm 287 21 - - JJ cord-265139-x7g3jcjm 287 22 coding coding JJ cord-265139-x7g3jcjm 287 23 RNA rna NN cord-265139-x7g3jcjm 287 24 and and CC cord-265139-x7g3jcjm 287 25 synonymous synonymous JJ cord-265139-x7g3jcjm 287 26 mutations mutation NNS cord-265139-x7g3jcjm 288 1 SnapShot snapshot JJ cord-265139-x7g3jcjm 288 2 : : : cord-265139-x7g3jcjm 288 3 Unconventional Unconventional NNP cord-265139-x7g3jcjm 288 4 miRNA miRNA NNP cord-265139-x7g3jcjm 288 5 Functions Functions NNPS cord-265139-x7g3jcjm 288 6 Modular Modular NNP cord-265139-x7g3jcjm 288 7 regulatory regulatory JJ cord-265139-x7g3jcjm 288 8 principles principle NNS cord-265139-x7g3jcjm 288 9 of of IN cord-265139-x7g3jcjm 288 10 large large JJ cord-265139-x7g3jcjm 288 11 non non JJ cord-265139-x7g3jcjm 288 12 - - JJ cord-265139-x7g3jcjm 288 13 coding coding JJ cord-265139-x7g3jcjm 288 14 RNAs rna NNS cord-265139-x7g3jcjm 288 15 Circles circle NNS cord-265139-x7g3jcjm 288 16 reshaping reshape VBG cord-265139-x7g3jcjm 288 17 the the DT cord-265139-x7g3jcjm 288 18 RNA RNA NNP cord-265139-x7g3jcjm 288 19 world world NN cord-265139-x7g3jcjm 288 20 : : : cord-265139-x7g3jcjm 288 21 from from IN cord-265139-x7g3jcjm 288 22 waste waste NN cord-265139-x7g3jcjm 288 23 to to IN cord-265139-x7g3jcjm 288 24 treasure treasure NN cord-265139-x7g3jcjm 288 25 Unique unique JJ cord-265139-x7g3jcjm 288 26 features feature NNS cord-265139-x7g3jcjm 288 27 of of IN cord-265139-x7g3jcjm 288 28 long long JJ cord-265139-x7g3jcjm 288 29 non non JJ cord-265139-x7g3jcjm 288 30 - - JJ cord-265139-x7g3jcjm 288 31 coding coding JJ cord-265139-x7g3jcjm 288 32 RNA rna NN cord-265139-x7g3jcjm 288 33 biogenesis biogenesis NN cord-265139-x7g3jcjm 288 34 and and CC cord-265139-x7g3jcjm 288 35 function function VB cord-265139-x7g3jcjm 288 36 Determining Determining NNP cord-265139-x7g3jcjm 288 37 Associations association NNS cord-265139-x7g3jcjm 288 38 between between IN cord-265139-x7g3jcjm 288 39 Human Human NNP cord-265139-x7g3jcjm 288 40 Diseases Diseases NNPS cord-265139-x7g3jcjm 288 41 and and CC cord-265139-x7g3jcjm 288 42 non non JJ cord-265139-x7g3jcjm 288 43 - - JJ cord-265139-x7g3jcjm 288 44 coding coding JJ cord-265139-x7g3jcjm 288 45 RNAs rna NNS cord-265139-x7g3jcjm 288 46 with with IN cord-265139-x7g3jcjm 288 47 Critical Critical NNP cord-265139-x7g3jcjm 288 48 Roles Roles NNPS cord-265139-x7g3jcjm 288 49 in in IN cord-265139-x7g3jcjm 288 50 Network Network NNP cord-265139-x7g3jcjm 288 51 Control Control NNP cord-265139-x7g3jcjm 288 52 Detecting Detecting NNP cord-265139-x7g3jcjm 288 53 and and CC cord-265139-x7g3jcjm 288 54 characterizing characterize VBG cord-265139-x7g3jcjm 288 55 circular circular JJ cord-265139-x7g3jcjm 288 56 RNAs rna NNS cord-265139-x7g3jcjm 288 57 The the DT cord-265139-x7g3jcjm 288 58 biogenesis biogenesis NN cord-265139-x7g3jcjm 288 59 and and CC cord-265139-x7g3jcjm 288 60 emerging emerge VBG cord-265139-x7g3jcjm 288 61 roles role NNS cord-265139-x7g3jcjm 288 62 of of IN cord-265139-x7g3jcjm 288 63 circular circular JJ cord-265139-x7g3jcjm 288 64 RNAs rna NNS cord-265139-x7g3jcjm 289 1 The the DT cord-265139-x7g3jcjm 289 2 biogenesis biogenesis NN cord-265139-x7g3jcjm 289 3 , , , cord-265139-x7g3jcjm 289 4 biology biology NN cord-265139-x7g3jcjm 289 5 and and CC cord-265139-x7g3jcjm 289 6 characterization characterization NN cord-265139-x7g3jcjm 289 7 of of IN cord-265139-x7g3jcjm 289 8 circular circular JJ cord-265139-x7g3jcjm 289 9 RNAs rna NNS cord-265139-x7g3jcjm 289 10 The the DT cord-265139-x7g3jcjm 289 11 Biogenesis Biogenesis NNP cord-265139-x7g3jcjm 289 12 , , , cord-265139-x7g3jcjm 289 13 Functions Functions NNPS cord-265139-x7g3jcjm 289 14 , , , cord-265139-x7g3jcjm 289 15 and and CC cord-265139-x7g3jcjm 289 16 Challenges challenge NNS cord-265139-x7g3jcjm 289 17 of of IN cord-265139-x7g3jcjm 289 18 Circular Circular NNP cord-265139-x7g3jcjm 289 19 RNAs RNAs NNPS cord-265139-x7g3jcjm 289 20 Circular Circular NNP cord-265139-x7g3jcjm 289 21 RNA RNA NNP cord-265139-x7g3jcjm 289 22 profiling profiling NN cord-265139-x7g3jcjm 289 23 reveals reveal VBZ cord-265139-x7g3jcjm 289 24 an an DT cord-265139-x7g3jcjm 289 25 abundant abundant JJ cord-265139-x7g3jcjm 289 26 circHIPK3 circhipk3 NN cord-265139-x7g3jcjm 289 27 that that WDT cord-265139-x7g3jcjm 289 28 regulates regulate VBZ cord-265139-x7g3jcjm 289 29 cell cell NN cord-265139-x7g3jcjm 289 30 growth growth NN cord-265139-x7g3jcjm 289 31 by by IN cord-265139-x7g3jcjm 289 32 sponging sponge VBG cord-265139-x7g3jcjm 289 33 multiple multiple JJ cord-265139-x7g3jcjm 289 34 miRNAs miRNAs NNP cord-265139-x7g3jcjm 289 35 Circular circular JJ cord-265139-x7g3jcjm 289 36 RNAs rna NNS cord-265139-x7g3jcjm 289 37 Co Co NNP cord-265139-x7g3jcjm 289 38 - - HYPH cord-265139-x7g3jcjm 289 39 Precipitate precipitate VB cord-265139-x7g3jcjm 289 40 with with IN cord-265139-x7g3jcjm 289 41 Extracellular Extracellular NNP cord-265139-x7g3jcjm 289 42 Vesicles Vesicles NNP cord-265139-x7g3jcjm 289 43 : : : cord-265139-x7g3jcjm 290 1 A a DT cord-265139-x7g3jcjm 290 2 Possible possible JJ cord-265139-x7g3jcjm 290 3 Mechanism Mechanism NNP cord-265139-x7g3jcjm 290 4 for for IN cord-265139-x7g3jcjm 290 5 circRNA circRNA NNP cord-265139-x7g3jcjm 290 6 Clearance Clearance NNP cord-265139-x7g3jcjm 290 7 Circular Circular NNP cord-265139-x7g3jcjm 290 8 RNAs rna NNS cord-265139-x7g3jcjm 290 9 are be VBP cord-265139-x7g3jcjm 290 10 abundant abundant JJ cord-265139-x7g3jcjm 290 11 , , , cord-265139-x7g3jcjm 290 12 conserved conserved JJ cord-265139-x7g3jcjm 290 13 , , , cord-265139-x7g3jcjm 290 14 and and CC cord-265139-x7g3jcjm 290 15 associated associate VBN cord-265139-x7g3jcjm 290 16 with with IN cord-265139-x7g3jcjm 290 17 ALU ALU NNP cord-265139-x7g3jcjm 291 1 repeats repeat VBZ cord-265139-x7g3jcjm 291 2 Circular circular JJ cord-265139-x7g3jcjm 291 3 RNAs rna NNS cord-265139-x7g3jcjm 291 4 are be VBP cord-265139-x7g3jcjm 291 5 the the DT cord-265139-x7g3jcjm 291 6 predominant predominant JJ cord-265139-x7g3jcjm 291 7 transcript transcript NN cord-265139-x7g3jcjm 291 8 isoform isoform NN cord-265139-x7g3jcjm 291 9 from from IN cord-265139-x7g3jcjm 291 10 hundreds hundred NNS cord-265139-x7g3jcjm 291 11 of of IN cord-265139-x7g3jcjm 291 12 human human JJ cord-265139-x7g3jcjm 291 13 genes gene NNS cord-265139-x7g3jcjm 291 14 in in IN cord-265139-x7g3jcjm 291 15 diverse diverse JJ cord-265139-x7g3jcjm 291 16 cell cell NN cord-265139-x7g3jcjm 291 17 types type NNS cord-265139-x7g3jcjm 291 18 Circular circular JJ cord-265139-x7g3jcjm 291 19 RNAs rna NNS cord-265139-x7g3jcjm 291 20 are be VBP cord-265139-x7g3jcjm 291 21 a a DT cord-265139-x7g3jcjm 291 22 large large JJ cord-265139-x7g3jcjm 291 23 class class NN cord-265139-x7g3jcjm 291 24 of of IN cord-265139-x7g3jcjm 291 25 animal animal NN cord-265139-x7g3jcjm 291 26 RNAs rna NNS cord-265139-x7g3jcjm 291 27 with with IN cord-265139-x7g3jcjm 291 28 regulatory regulatory JJ cord-265139-x7g3jcjm 291 29 potency potency NN cord-265139-x7g3jcjm 291 30 Correction correction NN cord-265139-x7g3jcjm 291 31 : : : cord-265139-x7g3jcjm 291 32 Cell cell NN cord-265139-x7g3jcjm 291 33 - - HYPH cord-265139-x7g3jcjm 291 34 Type type NN cord-265139-x7g3jcjm 291 35 Specific specific NN cord-265139-x7g3jcjm 291 36 Features feature NNS cord-265139-x7g3jcjm 291 37 of of IN cord-265139-x7g3jcjm 291 38 Circular Circular NNP cord-265139-x7g3jcjm 291 39 RNA RNA NNP cord-265139-x7g3jcjm 291 40 Expression Expression NNP cord-265139-x7g3jcjm 291 41 Circular Circular NNP cord-265139-x7g3jcjm 291 42 RNA RNA NNP cord-265139-x7g3jcjm 291 43 : : : cord-265139-x7g3jcjm 292 1 A a DT cord-265139-x7g3jcjm 292 2 new new JJ cord-265139-x7g3jcjm 292 3 star star NN cord-265139-x7g3jcjm 292 4 of of IN cord-265139-x7g3jcjm 292 5 noncoding noncoding JJ cord-265139-x7g3jcjm 292 6 RNAs RNAs NNPS cord-265139-x7g3jcjm 292 7 Widespread Widespread NNP cord-265139-x7g3jcjm 292 8 noncoding noncoding JJ cord-265139-x7g3jcjm 292 9 circular circular JJ cord-265139-x7g3jcjm 292 10 RNAs rna NNS cord-265139-x7g3jcjm 292 11 in in IN cord-265139-x7g3jcjm 292 12 plants plant NNS cord-265139-x7g3jcjm 292 13 Circular Circular NNP cord-265139-x7g3jcjm 292 14 RNA RNA NNP cord-265139-x7g3jcjm 292 15 - - HYPH cord-265139-x7g3jcjm 292 16 protein protein NN cord-265139-x7g3jcjm 292 17 interactions interaction NNS cord-265139-x7g3jcjm 292 18 : : : cord-265139-x7g3jcjm 292 19 Functions function NNS cord-265139-x7g3jcjm 292 20 , , , cord-265139-x7g3jcjm 292 21 mechanisms mechanism NNS cord-265139-x7g3jcjm 292 22 , , , cord-265139-x7g3jcjm 292 23 and and CC cord-265139-x7g3jcjm 292 24 identification identification NN cord-265139-x7g3jcjm 292 25 Molecular molecular JJ cord-265139-x7g3jcjm 292 26 biology biology NN cord-265139-x7g3jcjm 292 27 . . . cord-265139-x7g3jcjm 293 1 A a DT cord-265139-x7g3jcjm 293 2 circuitous circuitous JJ cord-265139-x7g3jcjm 293 3 route route NN cord-265139-x7g3jcjm 293 4 to to IN cord-265139-x7g3jcjm 293 5 noncoding noncoding NNP cord-265139-x7g3jcjm 293 6 RNA RNA NNP cord-265139-x7g3jcjm 293 7 Natural Natural NNP cord-265139-x7g3jcjm 293 8 RNA RNA NNP cord-265139-x7g3jcjm 293 9 circles circle NNS cord-265139-x7g3jcjm 293 10 function function VBP cord-265139-x7g3jcjm 293 11 as as IN cord-265139-x7g3jcjm 293 12 efficient efficient JJ cord-265139-x7g3jcjm 293 13 microRNA microRNA NNP cord-265139-x7g3jcjm 293 14 sponges sponge VBZ cord-265139-x7g3jcjm 293 15 Circular circular JJ cord-265139-x7g3jcjm 293 16 RNAs rna NNS cord-265139-x7g3jcjm 293 17 in in IN cord-265139-x7g3jcjm 293 18 the the DT cord-265139-x7g3jcjm 293 19 Mammalian Mammalian NNP cord-265139-x7g3jcjm 293 20 Brain Brain NNP cord-265139-x7g3jcjm 293 21 Are be VBP cord-265139-x7g3jcjm 293 22 Highly highly RB cord-265139-x7g3jcjm 293 23 Abundant abundant JJ cord-265139-x7g3jcjm 293 24 , , , cord-265139-x7g3jcjm 293 25 Conserved conserved JJ cord-265139-x7g3jcjm 293 26 , , , cord-265139-x7g3jcjm 293 27 and and CC cord-265139-x7g3jcjm 293 28 Dynamically dynamically RB cord-265139-x7g3jcjm 293 29 Expressed express VBN cord-265139-x7g3jcjm 293 30 Loss Loss NNP cord-265139-x7g3jcjm 293 31 of of IN cord-265139-x7g3jcjm 293 32 a a DT cord-265139-x7g3jcjm 293 33 mammalian mammalian JJ cord-265139-x7g3jcjm 293 34 circular circular JJ cord-265139-x7g3jcjm 293 35 RNA RNA NNP cord-265139-x7g3jcjm 293 36 locus locus NN cord-265139-x7g3jcjm 294 1 causes cause VBZ cord-265139-x7g3jcjm 294 2 miRNA miRNA NNP cord-265139-x7g3jcjm 294 3 deregulation deregulation NN cord-265139-x7g3jcjm 294 4 and and CC cord-265139-x7g3jcjm 294 5 affects affect VBZ cord-265139-x7g3jcjm 294 6 brain brain NN cord-265139-x7g3jcjm 294 7 function function NN cord-265139-x7g3jcjm 295 1 The the DT cord-265139-x7g3jcjm 295 2 circular circular JJ cord-265139-x7g3jcjm 295 3 RNA RNA NNP cord-265139-x7g3jcjm 295 4 Cdr1as cdr1as NN cord-265139-x7g3jcjm 295 5 , , , cord-265139-x7g3jcjm 295 6 via via IN cord-265139-x7g3jcjm 295 7 miR-7 miR-7 NNP cord-265139-x7g3jcjm 295 8 and and CC cord-265139-x7g3jcjm 295 9 its -PRON- PRP$ cord-265139-x7g3jcjm 295 10 targets target NNS cord-265139-x7g3jcjm 295 11 , , , cord-265139-x7g3jcjm 295 12 regulates regulate VBZ cord-265139-x7g3jcjm 295 13 insulin insulin NN cord-265139-x7g3jcjm 295 14 transcription transcription NN cord-265139-x7g3jcjm 295 15 and and CC cord-265139-x7g3jcjm 295 16 secretion secretion NN cord-265139-x7g3jcjm 295 17 in in IN cord-265139-x7g3jcjm 295 18 islet islet NN cord-265139-x7g3jcjm 295 19 cells cell NNS cord-265139-x7g3jcjm 296 1 The the DT cord-265139-x7g3jcjm 296 2 Circular Circular NNP cord-265139-x7g3jcjm 296 3 RNA RNA NNP cord-265139-x7g3jcjm 296 4 Cdr1as Cdr1as NNP cord-265139-x7g3jcjm 296 5 Promotes promote VBZ cord-265139-x7g3jcjm 296 6 Myocardial Myocardial NNP cord-265139-x7g3jcjm 296 7 Infarction Infarction NNP cord-265139-x7g3jcjm 296 8 by by IN cord-265139-x7g3jcjm 296 9 Mediating mediate VBG cord-265139-x7g3jcjm 296 10 the the DT cord-265139-x7g3jcjm 296 11 Regulation Regulation NNP cord-265139-x7g3jcjm 296 12 of of IN cord-265139-x7g3jcjm 296 13 miR-7a mir-7a NN cord-265139-x7g3jcjm 296 14 on on IN cord-265139-x7g3jcjm 296 15 Its -PRON- PRP$ cord-265139-x7g3jcjm 296 16 Target Target NNP cord-265139-x7g3jcjm 296 17 Genes Genes NNPS cord-265139-x7g3jcjm 296 18 Expression Expression NNP cord-265139-x7g3jcjm 296 19 Exon Exon NNP cord-265139-x7g3jcjm 296 20 - - HYPH cord-265139-x7g3jcjm 296 21 intron intron NN cord-265139-x7g3jcjm 296 22 circular circular JJ cord-265139-x7g3jcjm 296 23 RNAs rna NNS cord-265139-x7g3jcjm 296 24 regulate regulate VBP cord-265139-x7g3jcjm 296 25 transcription transcription NN cord-265139-x7g3jcjm 296 26 in in IN cord-265139-x7g3jcjm 296 27 the the DT cord-265139-x7g3jcjm 296 28 nucleus nucleus NN cord-265139-x7g3jcjm 296 29 Foxo3 Foxo3 NNP cord-265139-x7g3jcjm 296 30 circular circular JJ cord-265139-x7g3jcjm 296 31 RNA RNA NNP cord-265139-x7g3jcjm 296 32 retards retards NN cord-265139-x7g3jcjm 296 33 cell cell NN cord-265139-x7g3jcjm 296 34 cycle cycle NN cord-265139-x7g3jcjm 296 35 progression progression NN cord-265139-x7g3jcjm 296 36 via via IN cord-265139-x7g3jcjm 296 37 forming form VBG cord-265139-x7g3jcjm 296 38 ternary ternary JJ cord-265139-x7g3jcjm 296 39 complexes complex NNS cord-265139-x7g3jcjm 296 40 with with IN cord-265139-x7g3jcjm 296 41 p21 p21 NN cord-265139-x7g3jcjm 296 42 and and CC cord-265139-x7g3jcjm 296 43 CDK2 CDK2 NNP cord-265139-x7g3jcjm 296 44 Circular Circular NNP cord-265139-x7g3jcjm 296 45 RNA RNA NNP cord-265139-x7g3jcjm 297 1 participates participate VBZ cord-265139-x7g3jcjm 297 2 in in IN cord-265139-x7g3jcjm 297 3 the the DT cord-265139-x7g3jcjm 297 4 carcinogenesis carcinogenesis NN cord-265139-x7g3jcjm 297 5 and and CC cord-265139-x7g3jcjm 297 6 the the DT cord-265139-x7g3jcjm 297 7 malignant malignant JJ cord-265139-x7g3jcjm 297 8 behavior behavior NN cord-265139-x7g3jcjm 297 9 of of IN cord-265139-x7g3jcjm 297 10 cancer cancer NN cord-265139-x7g3jcjm 297 11 Identification Identification NNP cord-265139-x7g3jcjm 297 12 of of IN cord-265139-x7g3jcjm 297 13 HuR HuR NNP cord-265139-x7g3jcjm 297 14 target target NN cord-265139-x7g3jcjm 297 15 circular circular JJ cord-265139-x7g3jcjm 297 16 RNAs rna NNS cord-265139-x7g3jcjm 297 17 uncovers uncover VBZ cord-265139-x7g3jcjm 297 18 suppression suppression NN cord-265139-x7g3jcjm 297 19 of of IN cord-265139-x7g3jcjm 297 20 PABPN1 pabpn1 JJ cord-265139-x7g3jcjm 297 21 translation translation NN cord-265139-x7g3jcjm 297 22 by by IN cord-265139-x7g3jcjm 297 23 CircPABPN1 CircPABPN1 NNP cord-265139-x7g3jcjm 298 1 Circular circular JJ cord-265139-x7g3jcjm 298 2 non non JJ cord-265139-x7g3jcjm 298 3 - - JJ cord-265139-x7g3jcjm 298 4 coding code VBG cord-265139-x7g3jcjm 298 5 RNA RNA NNP cord-265139-x7g3jcjm 298 6 ANRIL ANRIL NNP cord-265139-x7g3jcjm 298 7 modulates modulate VBZ cord-265139-x7g3jcjm 298 8 ribosomal ribosomal JJ cord-265139-x7g3jcjm 298 9 RNA RNA NNP cord-265139-x7g3jcjm 298 10 maturation maturation NN cord-265139-x7g3jcjm 298 11 and and CC cord-265139-x7g3jcjm 298 12 atherosclerosis atherosclerosis NN cord-265139-x7g3jcjm 298 13 in in IN cord-265139-x7g3jcjm 298 14 humans human NNS cord-265139-x7g3jcjm 299 1 Identifying identify VBG cord-265139-x7g3jcjm 299 2 and and CC cord-265139-x7g3jcjm 299 3 Characterizing characterize VBG cord-265139-x7g3jcjm 299 4 circRNA circrna VB cord-265139-x7g3jcjm 299 5 - - HYPH cord-265139-x7g3jcjm 299 6 Protein Protein NNP cord-265139-x7g3jcjm 299 7 Interaction Interaction NNP cord-265139-x7g3jcjm 299 8 Identifying identify VBG cord-265139-x7g3jcjm 299 9 RBP RBP NNP cord-265139-x7g3jcjm 299 10 - - HYPH cord-265139-x7g3jcjm 299 11 Binding Binding NNP cord-265139-x7g3jcjm 299 12 Sites Sites NNPS cord-265139-x7g3jcjm 299 13 on on IN cord-265139-x7g3jcjm 299 14 circRNAs circrna NNS cord-265139-x7g3jcjm 299 15 via via IN cord-265139-x7g3jcjm 299 16 Sequence sequence NN cord-265139-x7g3jcjm 299 17 Labeling labeling NN cord-265139-x7g3jcjm 299 18 Neural Neural NNP cord-265139-x7g3jcjm 299 19 Networks Networks NNPS cord-265139-x7g3jcjm 299 20 . . . cord-265139-x7g3jcjm 300 1 Front front NN cord-265139-x7g3jcjm 300 2 . . . cord-265139-x7g3jcjm 301 1 Genet Genet NNP cord-265139-x7g3jcjm 301 2 Translation Translation NNP cord-265139-x7g3jcjm 301 3 and and CC cord-265139-x7g3jcjm 301 4 functional functional JJ cord-265139-x7g3jcjm 301 5 roles role NNS cord-265139-x7g3jcjm 301 6 of of IN cord-265139-x7g3jcjm 301 7 circular circular JJ cord-265139-x7g3jcjm 301 8 RNAs rna NNS cord-265139-x7g3jcjm 301 9 in in IN cord-265139-x7g3jcjm 301 10 human human JJ cord-265139-x7g3jcjm 301 11 cancer cancer NN cord-265139-x7g3jcjm 301 12 Initiation Initiation NNP cord-265139-x7g3jcjm 301 13 of of IN cord-265139-x7g3jcjm 301 14 protein protein NN cord-265139-x7g3jcjm 301 15 synthesis synthesis NN cord-265139-x7g3jcjm 301 16 by by IN cord-265139-x7g3jcjm 301 17 the the DT cord-265139-x7g3jcjm 301 18 eukaryotic eukaryotic JJ cord-265139-x7g3jcjm 301 19 translational translational JJ cord-265139-x7g3jcjm 301 20 apparatus apparatus NN cord-265139-x7g3jcjm 301 21 on on IN cord-265139-x7g3jcjm 301 22 circular circular JJ cord-265139-x7g3jcjm 301 23 RNAs rna NNS cord-265139-x7g3jcjm 302 1 Extensive extensive JJ cord-265139-x7g3jcjm 302 2 translation translation NN cord-265139-x7g3jcjm 302 3 of of IN cord-265139-x7g3jcjm 302 4 circular circular JJ cord-265139-x7g3jcjm 302 5 RNAs rna NNS cord-265139-x7g3jcjm 302 6 driven drive VBN cord-265139-x7g3jcjm 302 7 by by IN cord-265139-x7g3jcjm 302 8 N6-methyladenosine n6-methyladenosine CC cord-265139-x7g3jcjm 302 9 Circ Circ NNP cord-265139-x7g3jcjm 302 10 - - HYPH cord-265139-x7g3jcjm 302 11 ZNF609 ZNF609 NNP cord-265139-x7g3jcjm 302 12 Is be VBZ cord-265139-x7g3jcjm 302 13 a a DT cord-265139-x7g3jcjm 302 14 Circular Circular NNP cord-265139-x7g3jcjm 302 15 RNA RNA NNP cord-265139-x7g3jcjm 302 16 that that WDT cord-265139-x7g3jcjm 302 17 Can Can MD cord-265139-x7g3jcjm 302 18 Be be VB cord-265139-x7g3jcjm 302 19 Translated translate VBN cord-265139-x7g3jcjm 302 20 and and CC cord-265139-x7g3jcjm 302 21 Functions Functions NNPS cord-265139-x7g3jcjm 302 22 in in IN cord-265139-x7g3jcjm 302 23 Myogenesis Myogenesis NNP cord-265139-x7g3jcjm 302 24 Translation Translation NNP cord-265139-x7g3jcjm 302 25 of of IN cord-265139-x7g3jcjm 302 26 the the DT cord-265139-x7g3jcjm 302 27 circular circular JJ cord-265139-x7g3jcjm 302 28 RNA RNA NNP cord-265139-x7g3jcjm 302 29 circbeta circbeta NN cord-265139-x7g3jcjm 302 30 - - HYPH cord-265139-x7g3jcjm 302 31 catenin catenin NNP cord-265139-x7g3jcjm 303 1 promotes promote VBZ cord-265139-x7g3jcjm 303 2 liver liver NN cord-265139-x7g3jcjm 303 3 cancer cancer NN cord-265139-x7g3jcjm 303 4 cell cell NN cord-265139-x7g3jcjm 303 5 growth growth NN cord-265139-x7g3jcjm 303 6 through through IN cord-265139-x7g3jcjm 303 7 activation activation NN cord-265139-x7g3jcjm 303 8 of of IN cord-265139-x7g3jcjm 303 9 the the DT cord-265139-x7g3jcjm 303 10 Wnt Wnt NNP cord-265139-x7g3jcjm 303 11 pathway pathway NN cord-265139-x7g3jcjm 303 12 A a DT cord-265139-x7g3jcjm 303 13 peptide peptide NN cord-265139-x7g3jcjm 303 14 encoded encode VBN cord-265139-x7g3jcjm 303 15 by by IN cord-265139-x7g3jcjm 303 16 circular circular JJ cord-265139-x7g3jcjm 303 17 form form NN cord-265139-x7g3jcjm 303 18 of of IN cord-265139-x7g3jcjm 303 19 LINC LINC NNP cord-265139-x7g3jcjm 303 20 - - HYPH cord-265139-x7g3jcjm 303 21 PINT PINT NNP cord-265139-x7g3jcjm 303 22 suppresses suppress VBZ cord-265139-x7g3jcjm 303 23 oncogenic oncogenic JJ cord-265139-x7g3jcjm 303 24 transcriptional transcriptional JJ cord-265139-x7g3jcjm 303 25 elongation elongation NN cord-265139-x7g3jcjm 303 26 in in IN cord-265139-x7g3jcjm 303 27 glioblastoma glioblastoma NN cord-265139-x7g3jcjm 303 28 Exosomal Exosomal NNP cord-265139-x7g3jcjm 303 29 circRNAs circrnas XX cord-265139-x7g3jcjm 303 30 : : : cord-265139-x7g3jcjm 304 1 Biogenesis biogenesis NN cord-265139-x7g3jcjm 304 2 , , , cord-265139-x7g3jcjm 304 3 effect effect NN cord-265139-x7g3jcjm 304 4 and and CC cord-265139-x7g3jcjm 304 5 application application NN cord-265139-x7g3jcjm 304 6 in in IN cord-265139-x7g3jcjm 304 7 human human JJ cord-265139-x7g3jcjm 304 8 diseases disease NNS cord-265139-x7g3jcjm 305 1 Selective selective JJ cord-265139-x7g3jcjm 305 2 release release NN cord-265139-x7g3jcjm 305 3 of of IN cord-265139-x7g3jcjm 305 4 circRNAs circrna NNS cord-265139-x7g3jcjm 305 5 in in IN cord-265139-x7g3jcjm 305 6 platelet platelet NN cord-265139-x7g3jcjm 305 7 - - HYPH cord-265139-x7g3jcjm 305 8 derived derive VBN cord-265139-x7g3jcjm 305 9 extracellular extracellular JJ cord-265139-x7g3jcjm 305 10 vesicles vesicle NNS cord-265139-x7g3jcjm 305 11 IL-13 IL-13 NNP cord-265139-x7g3jcjm 305 12 secreted secrete VBN cord-265139-x7g3jcjm 305 13 by by IN cord-265139-x7g3jcjm 305 14 ILC2s ILC2s NNP cord-265139-x7g3jcjm 305 15 promotes promote VBZ cord-265139-x7g3jcjm 305 16 the the DT cord-265139-x7g3jcjm 305 17 self self NN cord-265139-x7g3jcjm 305 18 - - HYPH cord-265139-x7g3jcjm 305 19 renewal renewal NN cord-265139-x7g3jcjm 305 20 of of IN cord-265139-x7g3jcjm 305 21 intestinal intestinal JJ cord-265139-x7g3jcjm 305 22 stem stem NN cord-265139-x7g3jcjm 305 23 cells cell NNS cord-265139-x7g3jcjm 305 24 through through IN cord-265139-x7g3jcjm 305 25 circular circular JJ cord-265139-x7g3jcjm 305 26 RNA RNA NNP cord-265139-x7g3jcjm 305 27 circPan3 circPan3 . cord-265139-x7g3jcjm 305 28 Circular circular JJ cord-265139-x7g3jcjm 305 29 RNAs rna NNS cord-265139-x7g3jcjm 305 30 : : : cord-265139-x7g3jcjm 306 1 Novel novel JJ cord-265139-x7g3jcjm 306 2 Regulators regulator NNS cord-265139-x7g3jcjm 306 3 of of IN cord-265139-x7g3jcjm 306 4 Neuronal Neuronal NNP cord-265139-x7g3jcjm 306 5 Development Development NNP cord-265139-x7g3jcjm 306 6 Circular Circular NNP cord-265139-x7g3jcjm 306 7 RNAs rna NNS cord-265139-x7g3jcjm 306 8 as as IN cord-265139-x7g3jcjm 306 9 Potential potential JJ cord-265139-x7g3jcjm 306 10 Biomarkers Biomarkers NNPS cord-265139-x7g3jcjm 306 11 and and CC cord-265139-x7g3jcjm 306 12 Therapeutic therapeutic JJ cord-265139-x7g3jcjm 306 13 Targets Targets NNPS cord-265139-x7g3jcjm 306 14 for for IN cord-265139-x7g3jcjm 306 15 Metabolic metabolic JJ cord-265139-x7g3jcjm 306 16 Diseases Diseases NNPS cord-265139-x7g3jcjm 306 17 Circular circular JJ cord-265139-x7g3jcjm 306 18 RNAs rna NNS cord-265139-x7g3jcjm 306 19 in in IN cord-265139-x7g3jcjm 306 20 hypertension hypertension NN cord-265139-x7g3jcjm 306 21 : : : cord-265139-x7g3jcjm 306 22 Challenges challenge NNS cord-265139-x7g3jcjm 306 23 and and CC cord-265139-x7g3jcjm 306 24 clinical clinical JJ cord-265139-x7g3jcjm 306 25 promise promise NN cord-265139-x7g3jcjm 307 1 A a DT cord-265139-x7g3jcjm 307 2 circular circular JJ cord-265139-x7g3jcjm 307 3 RNA RNA NNP cord-265139-x7g3jcjm 307 4 protects protect VBZ cord-265139-x7g3jcjm 307 5 the the DT cord-265139-x7g3jcjm 307 6 heart heart NN cord-265139-x7g3jcjm 307 7 from from IN cord-265139-x7g3jcjm 307 8 pathological pathological JJ cord-265139-x7g3jcjm 307 9 hypertrophy hypertrophy NN cord-265139-x7g3jcjm 307 10 and and CC cord-265139-x7g3jcjm 307 11 heart heart NN cord-265139-x7g3jcjm 307 12 failure failure NN cord-265139-x7g3jcjm 307 13 by by IN cord-265139-x7g3jcjm 307 14 targeting target VBG cord-265139-x7g3jcjm 307 15 miR-223 miR-223 VBN cord-265139-x7g3jcjm 308 1 The the DT cord-265139-x7g3jcjm 308 2 circular circular JJ cord-265139-x7g3jcjm 308 3 RNA RNA NNP cord-265139-x7g3jcjm 308 4 MICRA MICRA NNP cord-265139-x7g3jcjm 308 5 for for IN cord-265139-x7g3jcjm 308 6 risk risk NN cord-265139-x7g3jcjm 308 7 stratification stratification NN cord-265139-x7g3jcjm 308 8 after after IN cord-265139-x7g3jcjm 308 9 myocardial myocardial JJ cord-265139-x7g3jcjm 308 10 infarction infarction NN cord-265139-x7g3jcjm 308 11 Signature Signature NNP cord-265139-x7g3jcjm 308 12 as as IN cord-265139-x7g3jcjm 308 13 Potential Potential NNP cord-265139-x7g3jcjm 308 14 Diagnostic Diagnostic NNP cord-265139-x7g3jcjm 308 15 and and CC cord-265139-x7g3jcjm 308 16 Prognostic Prognostic NNP cord-265139-x7g3jcjm 308 17 Biomarker Biomarker NNP cord-265139-x7g3jcjm 308 18 for for IN cord-265139-x7g3jcjm 308 19 Diabetes diabetes NN cord-265139-x7g3jcjm 308 20 Mellitus Mellitus NNP cord-265139-x7g3jcjm 308 21 and and CC cord-265139-x7g3jcjm 308 22 Related relate VBN cord-265139-x7g3jcjm 308 23 Cardiovascular Cardiovascular NNP cord-265139-x7g3jcjm 308 24 Complications Complications NNPS cord-265139-x7g3jcjm 308 25 Silencing Silencing NNP cord-265139-x7g3jcjm 308 26 of of IN cord-265139-x7g3jcjm 308 27 Circular Circular NNP cord-265139-x7g3jcjm 308 28 RNA RNA NNP cord-265139-x7g3jcjm 308 29 - - HYPH cord-265139-x7g3jcjm 308 30 ZNF609 ZNF609 NNP cord-265139-x7g3jcjm 309 1 Ameliorates Ameliorates NNP cord-265139-x7g3jcjm 309 2 Vascular Vascular NNP cord-265139-x7g3jcjm 309 3 Endothelial Endothelial NNP cord-265139-x7g3jcjm 309 4 Dysfunction Dysfunction NNP cord-265139-x7g3jcjm 309 5 From from IN cord-265139-x7g3jcjm 309 6 genotype genotype NN cord-265139-x7g3jcjm 309 7 to to IN cord-265139-x7g3jcjm 309 8 phenotype phenotype NN cord-265139-x7g3jcjm 309 9 in in IN cord-265139-x7g3jcjm 309 10 human human JJ cord-265139-x7g3jcjm 309 11 atherosclerosis atherosclerosis NN cord-265139-x7g3jcjm 309 12 - - HYPH cord-265139-x7g3jcjm 309 13 recent recent JJ cord-265139-x7g3jcjm 309 14 findings finding NNS cord-265139-x7g3jcjm 310 1 circRNA_0046367 circRNA_0046367 NNP cord-265139-x7g3jcjm 310 2 Prevents prevent VBZ cord-265139-x7g3jcjm 310 3 Hepatoxicity Hepatoxicity NNP cord-265139-x7g3jcjm 310 4 of of IN cord-265139-x7g3jcjm 310 5 Lipid Lipid NNP cord-265139-x7g3jcjm 310 6 Peroxidation Peroxidation NNP cord-265139-x7g3jcjm 310 7 : : : cord-265139-x7g3jcjm 311 1 An an DT cord-265139-x7g3jcjm 311 2 Inhibitory inhibitory JJ cord-265139-x7g3jcjm 311 3 Role role NN cord-265139-x7g3jcjm 311 4 against against IN cord-265139-x7g3jcjm 311 5 Hepatic Hepatic NNP cord-265139-x7g3jcjm 311 6 Steatosis Steatosis NNP cord-265139-x7g3jcjm 311 7 FTO FTO NNP cord-265139-x7g3jcjm 311 8 : : : cord-265139-x7g3jcjm 311 9 the the DT cord-265139-x7g3jcjm 311 10 first first JJ cord-265139-x7g3jcjm 311 11 gene gene NN cord-265139-x7g3jcjm 311 12 contributing contribute VBG cord-265139-x7g3jcjm 311 13 to to IN cord-265139-x7g3jcjm 311 14 common common JJ cord-265139-x7g3jcjm 311 15 forms form NNS cord-265139-x7g3jcjm 311 16 of of IN cord-265139-x7g3jcjm 311 17 human human JJ cord-265139-x7g3jcjm 311 18 obesity obesity NN cord-265139-x7g3jcjm 311 19 AMPK AMPK NNP cord-265139-x7g3jcjm 311 20 as as IN cord-265139-x7g3jcjm 311 21 Target Target NNP cord-265139-x7g3jcjm 311 22 for for IN cord-265139-x7g3jcjm 311 23 Intervention Intervention NNP cord-265139-x7g3jcjm 311 24 in in IN cord-265139-x7g3jcjm 311 25 Childhood Childhood NNP cord-265139-x7g3jcjm 311 26 and and CC cord-265139-x7g3jcjm 311 27 Adolescent Adolescent NNP cord-265139-x7g3jcjm 311 28 Obesity Obesity NNP cord-265139-x7g3jcjm 311 29 Risk Risk NNP cord-265139-x7g3jcjm 311 30 Factors Factors NNPS cord-265139-x7g3jcjm 311 31 , , , cord-265139-x7g3jcjm 311 32 and and CC cord-265139-x7g3jcjm 311 33 Genetic genetic JJ cord-265139-x7g3jcjm 311 34 Traits trait NNS cord-265139-x7g3jcjm 311 35 in in IN cord-265139-x7g3jcjm 311 36 Metabolically metabolically RB cord-265139-x7g3jcjm 311 37 Healthy healthy JJ cord-265139-x7g3jcjm 311 38 and and CC cord-265139-x7g3jcjm 311 39 Unhealthy unhealthy JJ cord-265139-x7g3jcjm 311 40 Obese obese JJ cord-265139-x7g3jcjm 311 41 Individuals individual NNS cord-265139-x7g3jcjm 311 42 Exposing expose VBG cord-265139-x7g3jcjm 311 43 the the DT cord-265139-x7g3jcjm 311 44 exposures exposure NNS cord-265139-x7g3jcjm 311 45 responsible responsible JJ cord-265139-x7g3jcjm 311 46 for for IN cord-265139-x7g3jcjm 311 47 type type NN cord-265139-x7g3jcjm 311 48 2 2 CD cord-265139-x7g3jcjm 311 49 diabetes diabete NNS cord-265139-x7g3jcjm 311 50 and and CC cord-265139-x7g3jcjm 311 51 obesity obesity NN cord-265139-x7g3jcjm 311 52 Obesity obesity NN cord-265139-x7g3jcjm 311 53 a a DT cord-265139-x7g3jcjm 311 54 Risk Risk NNP cord-265139-x7g3jcjm 311 55 Factor Factor NNP cord-265139-x7g3jcjm 311 56 for for IN cord-265139-x7g3jcjm 311 57 Severe severe JJ cord-265139-x7g3jcjm 311 58 COVID-19 COVID-19 NNP cord-265139-x7g3jcjm 311 59 Infection infection NN cord-265139-x7g3jcjm 311 60 : : : cord-265139-x7g3jcjm 311 61 Multiple multiple JJ cord-265139-x7g3jcjm 311 62 Potential potential JJ cord-265139-x7g3jcjm 311 63 Mechanisms Mechanisms NNPS cord-265139-x7g3jcjm 311 64 Obesity obesity NN cord-265139-x7g3jcjm 311 65 and and CC cord-265139-x7g3jcjm 311 66 impaired impair VBD cord-265139-x7g3jcjm 311 67 metabolic metabolic JJ cord-265139-x7g3jcjm 311 68 health health NN cord-265139-x7g3jcjm 311 69 in in IN cord-265139-x7g3jcjm 311 70 patients patient NNS cord-265139-x7g3jcjm 311 71 with with IN cord-265139-x7g3jcjm 311 72 COVID-19 COVID-19 NNP cord-265139-x7g3jcjm 311 73 Variation Variation NNP cord-265139-x7g3jcjm 311 74 in in IN cord-265139-x7g3jcjm 311 75 the the DT cord-265139-x7g3jcjm 311 76 heritability heritability NN cord-265139-x7g3jcjm 311 77 of of IN cord-265139-x7g3jcjm 311 78 body body NNP cord-265139-x7g3jcjm 311 79 mass mass NNP cord-265139-x7g3jcjm 311 80 index index NN cord-265139-x7g3jcjm 311 81 based base VBN cord-265139-x7g3jcjm 311 82 on on IN cord-265139-x7g3jcjm 311 83 diverse diverse JJ cord-265139-x7g3jcjm 311 84 twin twin JJ cord-265139-x7g3jcjm 311 85 studies study NNS cord-265139-x7g3jcjm 311 86 : : : cord-265139-x7g3jcjm 311 87 A a DT cord-265139-x7g3jcjm 311 88 systematic systematic JJ cord-265139-x7g3jcjm 311 89 review review NN cord-265139-x7g3jcjm 312 1 Genetic genetic JJ cord-265139-x7g3jcjm 312 2 studies study NNS cord-265139-x7g3jcjm 312 3 of of IN cord-265139-x7g3jcjm 312 4 body body NNP cord-265139-x7g3jcjm 312 5 mass mass NNP cord-265139-x7g3jcjm 312 6 index index NN cord-265139-x7g3jcjm 312 7 yield yield VB cord-265139-x7g3jcjm 312 8 new new JJ cord-265139-x7g3jcjm 312 9 insights insight NNS cord-265139-x7g3jcjm 312 10 for for IN cord-265139-x7g3jcjm 312 11 obesity obesity NN cord-265139-x7g3jcjm 312 12 biology biology NN cord-265139-x7g3jcjm 312 13 GWAS GWAS NNP cord-265139-x7g3jcjm 312 14 for for IN cord-265139-x7g3jcjm 312 15 BMI BMI NNP cord-265139-x7g3jcjm 312 16 : : : cord-265139-x7g3jcjm 312 17 A a DT cord-265139-x7g3jcjm 312 18 treasure treasure NN cord-265139-x7g3jcjm 312 19 trove trove NN cord-265139-x7g3jcjm 312 20 of of IN cord-265139-x7g3jcjm 312 21 fundamental fundamental JJ cord-265139-x7g3jcjm 312 22 insights insight NNS cord-265139-x7g3jcjm 312 23 into into IN cord-265139-x7g3jcjm 312 24 the the DT cord-265139-x7g3jcjm 312 25 genetic genetic JJ cord-265139-x7g3jcjm 312 26 basis basis NN cord-265139-x7g3jcjm 312 27 of of IN cord-265139-x7g3jcjm 312 28 obesity obesity NN cord-265139-x7g3jcjm 312 29 Epigenetics Epigenetics NNP cord-265139-x7g3jcjm 312 30 : : : cord-265139-x7g3jcjm 313 1 An an DT cord-265139-x7g3jcjm 313 2 overview overview NN cord-265139-x7g3jcjm 313 3 Epigenetic epigenetic JJ cord-265139-x7g3jcjm 313 4 regulation regulation NN cord-265139-x7g3jcjm 313 5 of of IN cord-265139-x7g3jcjm 313 6 ageing age VBG cord-265139-x7g3jcjm 313 7 : : : cord-265139-x7g3jcjm 313 8 linking link VBG cord-265139-x7g3jcjm 313 9 environmental environmental JJ cord-265139-x7g3jcjm 313 10 inputs input NNS cord-265139-x7g3jcjm 313 11 to to IN cord-265139-x7g3jcjm 313 12 genomic genomic JJ cord-265139-x7g3jcjm 313 13 stability stability NN cord-265139-x7g3jcjm 313 14 Wnt Wnt NNP cord-265139-x7g3jcjm 313 15 and and CC cord-265139-x7g3jcjm 313 16 PPARγ PPARγ NNS cord-265139-x7g3jcjm 313 17 signaling signal VBG cord-265139-x7g3jcjm 313 18 in in IN cord-265139-x7g3jcjm 313 19 osteoblastogenesis osteoblastogenesis NN cord-265139-x7g3jcjm 313 20 and and CC cord-265139-x7g3jcjm 313 21 adipogenesis adipogenesis NN cord-265139-x7g3jcjm 313 22 MicroRNAs MicroRNAs NNP cord-265139-x7g3jcjm 313 23 in in IN cord-265139-x7g3jcjm 313 24 adipose adipose JJ cord-265139-x7g3jcjm 313 25 tissue tissue NN cord-265139-x7g3jcjm 313 26 : : : cord-265139-x7g3jcjm 313 27 Their -PRON- PRP$ cord-265139-x7g3jcjm 313 28 role role NN cord-265139-x7g3jcjm 313 29 in in IN cord-265139-x7g3jcjm 313 30 adipogenesis adipogenesis NN cord-265139-x7g3jcjm 313 31 and and CC cord-265139-x7g3jcjm 313 32 obesity obesity NN cord-265139-x7g3jcjm 314 1 The the DT cord-265139-x7g3jcjm 314 2 clinical clinical JJ cord-265139-x7g3jcjm 314 3 potential potential NN cord-265139-x7g3jcjm 314 4 of of IN cord-265139-x7g3jcjm 314 5 adipogenesis adipogenesis NN cord-265139-x7g3jcjm 314 6 and and CC cord-265139-x7g3jcjm 314 7 obesity obesity NN cord-265139-x7g3jcjm 314 8 - - HYPH cord-265139-x7g3jcjm 314 9 related relate VBN cord-265139-x7g3jcjm 314 10 microRNAs microRNAs NNP cord-265139-x7g3jcjm 314 11 Long long JJ cord-265139-x7g3jcjm 314 12 noncoding noncoding JJ cord-265139-x7g3jcjm 314 13 RNAs rna NNS cord-265139-x7g3jcjm 314 14 regulate regulate VBP cord-265139-x7g3jcjm 314 15 adipogenesis adipogenesis NNP cord-265139-x7g3jcjm 314 16 Identification identification NN cord-265139-x7g3jcjm 314 17 and and CC cord-265139-x7g3jcjm 314 18 Characterization characterization NN cord-265139-x7g3jcjm 314 19 of of IN cord-265139-x7g3jcjm 314 20 CircRNAs circrna NNS cord-265139-x7g3jcjm 314 21 of of IN cord-265139-x7g3jcjm 314 22 Two two CD cord-265139-x7g3jcjm 314 23 Pig Pig NNP cord-265139-x7g3jcjm 314 24 Breeds Breeds NNPS cord-265139-x7g3jcjm 314 25 as as IN cord-265139-x7g3jcjm 314 26 a a DT cord-265139-x7g3jcjm 314 27 New New NNP cord-265139-x7g3jcjm 314 28 Biomarker Biomarker NNP cord-265139-x7g3jcjm 314 29 in in IN cord-265139-x7g3jcjm 314 30 Metabolism metabolism NN cord-265139-x7g3jcjm 314 31 - - HYPH cord-265139-x7g3jcjm 314 32 Related relate VBN cord-265139-x7g3jcjm 314 33 Diseases disease NNS cord-265139-x7g3jcjm 315 1 A a DT cord-265139-x7g3jcjm 315 2 genome genome NN cord-265139-x7g3jcjm 315 3 - - HYPH cord-265139-x7g3jcjm 315 4 wide wide JJ cord-265139-x7g3jcjm 315 5 landscape landscape NN cord-265139-x7g3jcjm 315 6 of of IN cord-265139-x7g3jcjm 315 7 mRNAs mrnas CD cord-265139-x7g3jcjm 315 8 , , , cord-265139-x7g3jcjm 315 9 lncRNAs lncrnas UH cord-265139-x7g3jcjm 315 10 , , , cord-265139-x7g3jcjm 315 11 and and CC cord-265139-x7g3jcjm 315 12 circRNAs circrna NNS cord-265139-x7g3jcjm 315 13 during during IN cord-265139-x7g3jcjm 315 14 subcutaneous subcutaneous JJ cord-265139-x7g3jcjm 315 15 adipogenesis adipogenesis NN cord-265139-x7g3jcjm 315 16 in in IN cord-265139-x7g3jcjm 315 17 pigs pig NNS cord-265139-x7g3jcjm 315 18 Circular Circular NNP cord-265139-x7g3jcjm 315 19 RNA RNA NNP cord-265139-x7g3jcjm 315 20 SAMD4A samd4a NN cord-265139-x7g3jcjm 316 1 controls control VBZ cord-265139-x7g3jcjm 316 2 adipogenesis adipogenesis NN cord-265139-x7g3jcjm 316 3 in in IN cord-265139-x7g3jcjm 316 4 obesity obesity NN cord-265139-x7g3jcjm 316 5 through through IN cord-265139-x7g3jcjm 316 6 the the DT cord-265139-x7g3jcjm 316 7 miR-138 mir-138 JJ cord-265139-x7g3jcjm 316 8 - - HYPH cord-265139-x7g3jcjm 316 9 5p 5p CD cord-265139-x7g3jcjm 316 10 / / SYM cord-265139-x7g3jcjm 316 11 EZH2 ezh2 NN cord-265139-x7g3jcjm 316 12 axis axis NN cord-265139-x7g3jcjm 316 13 Characterization characterization NN cord-265139-x7g3jcjm 316 14 of of IN cord-265139-x7g3jcjm 316 15 Circular circular JJ cord-265139-x7g3jcjm 316 16 RNAs rna NNS cord-265139-x7g3jcjm 316 17 in in IN cord-265139-x7g3jcjm 316 18 Chinese chinese JJ cord-265139-x7g3jcjm 316 19 Buffalo Buffalo NNP cord-265139-x7g3jcjm 317 1 ( ( -LRB- cord-265139-x7g3jcjm 317 2 Bubalus Bubalus NNP cord-265139-x7g3jcjm 317 3 bubalis bubalis NNP cord-265139-x7g3jcjm 317 4 ) ) -RRB- cord-265139-x7g3jcjm 318 1 Adipose Adipose NNP cord-265139-x7g3jcjm 318 2 Tissue tissue NN cord-265139-x7g3jcjm 318 3 : : : cord-265139-x7g3jcjm 319 1 A a DT cord-265139-x7g3jcjm 319 2 Focus Focus NNP cord-265139-x7g3jcjm 319 3 on on IN cord-265139-x7g3jcjm 319 4 Circular circular JJ cord-265139-x7g3jcjm 319 5 RNAs rna NNS cord-265139-x7g3jcjm 319 6 Involved involve VBN cord-265139-x7g3jcjm 319 7 in in IN cord-265139-x7g3jcjm 319 8 Fat fat JJ cord-265139-x7g3jcjm 319 9 Deposition Deposition NNP cord-265139-x7g3jcjm 319 10 . . . cord-265139-x7g3jcjm 320 1 Animals animal NNS cord-265139-x7g3jcjm 320 2 CircRNA circrna VBP cord-265139-x7g3jcjm 320 3 Expression expression NN cord-265139-x7g3jcjm 320 4 Profile Profile NNP cord-265139-x7g3jcjm 320 5 during during IN cord-265139-x7g3jcjm 320 6 Yak Yak NNP cord-265139-x7g3jcjm 320 7 Adipocyte Adipocyte NNP cord-265139-x7g3jcjm 320 8 Differentiation Differentiation NNP cord-265139-x7g3jcjm 320 9 and and CC cord-265139-x7g3jcjm 320 10 Screen screen NN cord-265139-x7g3jcjm 320 11 Potential potential JJ cord-265139-x7g3jcjm 320 12 circRNAs circrna NNS cord-265139-x7g3jcjm 320 13 for for IN cord-265139-x7g3jcjm 320 14 Adipocyte Adipocyte NNP cord-265139-x7g3jcjm 321 1 Differentiation Differentiation NNP cord-265139-x7g3jcjm 321 2 Circular Circular NNP cord-265139-x7g3jcjm 321 3 RNA RNA NNP cord-265139-x7g3jcjm 321 4 profiling profiling NN cord-265139-x7g3jcjm 321 5 reveals reveal VBZ cord-265139-x7g3jcjm 321 6 an an DT cord-265139-x7g3jcjm 321 7 abundant abundant JJ cord-265139-x7g3jcjm 321 8 circFUT10 circfut10 NN cord-265139-x7g3jcjm 321 9 that that WDT cord-265139-x7g3jcjm 321 10 promotes promote VBZ cord-265139-x7g3jcjm 321 11 adipocytes adipocyte NNS cord-265139-x7g3jcjm 321 12 proliferation proliferation NN cord-265139-x7g3jcjm 321 13 and and CC cord-265139-x7g3jcjm 321 14 inhibits inhibit VBZ cord-265139-x7g3jcjm 321 15 adipocytes adipocyte NNS cord-265139-x7g3jcjm 321 16 differentiation differentiation NN cord-265139-x7g3jcjm 321 17 via via IN cord-265139-x7g3jcjm 321 18 sponging sponge VBG cord-265139-x7g3jcjm 321 19 let-7 let-7 NNP cord-265139-x7g3jcjm 321 20 family family NN cord-265139-x7g3jcjm 321 21 members member NNS cord-265139-x7g3jcjm 321 22 Circular circular JJ cord-265139-x7g3jcjm 321 23 RNAs rna NNS cord-265139-x7g3jcjm 321 24 as as IN cord-265139-x7g3jcjm 321 25 novel novel JJ cord-265139-x7g3jcjm 321 26 regulators regulator NNS cord-265139-x7g3jcjm 321 27 of of IN cord-265139-x7g3jcjm 321 28 β β NN cord-265139-x7g3jcjm 321 29 - - HYPH cord-265139-x7g3jcjm 321 30 cell cell NN cord-265139-x7g3jcjm 321 31 functions function NNS cord-265139-x7g3jcjm 321 32 in in IN cord-265139-x7g3jcjm 321 33 normal normal JJ cord-265139-x7g3jcjm 321 34 and and CC cord-265139-x7g3jcjm 321 35 disease disease NN cord-265139-x7g3jcjm 321 36 conditions condition NNS cord-265139-x7g3jcjm 321 37 CircRNA circrna VBP cord-265139-x7g3jcjm 321 38 expression expression NN cord-265139-x7g3jcjm 321 39 profiles profile NNS cord-265139-x7g3jcjm 321 40 in in IN cord-265139-x7g3jcjm 321 41 human human JJ cord-265139-x7g3jcjm 321 42 visceral visceral JJ cord-265139-x7g3jcjm 321 43 preadipocytes preadipocyte NNS cord-265139-x7g3jcjm 321 44 and and CC cord-265139-x7g3jcjm 321 45 adipocytes adipocyte NNS cord-265139-x7g3jcjm 322 1 Adipose adipose JJ cord-265139-x7g3jcjm 322 2 circular circular JJ cord-265139-x7g3jcjm 322 3 RNAs rna NNS cord-265139-x7g3jcjm 322 4 exhibit exhibit VBP cord-265139-x7g3jcjm 322 5 dynamic dynamic JJ cord-265139-x7g3jcjm 322 6 regulation regulation NN cord-265139-x7g3jcjm 322 7 in in IN cord-265139-x7g3jcjm 322 8 obesity obesity NN cord-265139-x7g3jcjm 322 9 and and CC cord-265139-x7g3jcjm 322 10 functional functional JJ cord-265139-x7g3jcjm 322 11 role role NN cord-265139-x7g3jcjm 322 12 in in IN cord-265139-x7g3jcjm 322 13 adipogenesis adipogenesis NN cord-265139-x7g3jcjm 322 14 LincRNA LincRNA . cord-265139-x7g3jcjm 322 15 H19 H19 NNP cord-265139-x7g3jcjm 322 16 protects protect VBZ cord-265139-x7g3jcjm 322 17 from from IN cord-265139-x7g3jcjm 322 18 dietary dietary JJ cord-265139-x7g3jcjm 322 19 obesity obesity NN cord-265139-x7g3jcjm 322 20 by by IN cord-265139-x7g3jcjm 322 21 constraining constrain VBG cord-265139-x7g3jcjm 322 22 expression expression NN cord-265139-x7g3jcjm 322 23 of of IN cord-265139-x7g3jcjm 322 24 monoallelic monoallelic NNP cord-265139-x7g3jcjm 322 25 genes gene NNS cord-265139-x7g3jcjm 322 26 in in IN cord-265139-x7g3jcjm 322 27 brown brown JJ cord-265139-x7g3jcjm 322 28 fat fat JJ cord-265139-x7g3jcjm 322 29 Knock Knock NNP cord-265139-x7g3jcjm 322 30 - - HYPH cord-265139-x7g3jcjm 322 31 down down NN cord-265139-x7g3jcjm 322 32 of of IN cord-265139-x7g3jcjm 322 33 circular circular JJ cord-265139-x7g3jcjm 322 34 RNA RNA NNP cord-265139-x7g3jcjm 322 35 H19 H19 NNP cord-265139-x7g3jcjm 322 36 induces induce VBZ cord-265139-x7g3jcjm 322 37 human human JJ cord-265139-x7g3jcjm 322 38 adipose adipose NN cord-265139-x7g3jcjm 322 39 - - HYPH cord-265139-x7g3jcjm 322 40 derived derive VBN cord-265139-x7g3jcjm 322 41 stem stem NN cord-265139-x7g3jcjm 322 42 cells cell NNS cord-265139-x7g3jcjm 322 43 adipogenic adipogenic JJ cord-265139-x7g3jcjm 322 44 differentiation differentiation NN cord-265139-x7g3jcjm 322 45 via via IN cord-265139-x7g3jcjm 322 46 a a DT cord-265139-x7g3jcjm 322 47 mechanism mechanism NN cord-265139-x7g3jcjm 322 48 involving involve VBG cord-265139-x7g3jcjm 322 49 the the DT cord-265139-x7g3jcjm 322 50 polypyrimidine polypyrimidine JJ cord-265139-x7g3jcjm 322 51 tract tract NN cord-265139-x7g3jcjm 322 52 - - HYPH cord-265139-x7g3jcjm 322 53 binding bind VBG cord-265139-x7g3jcjm 322 54 protein protein NN cord-265139-x7g3jcjm 322 55 1 1 CD cord-265139-x7g3jcjm 322 56 Chromosome chromosome NN cord-265139-x7g3jcjm 322 57 9p21 9p21 CD cord-265139-x7g3jcjm 322 58 SNPs snp NNS cord-265139-x7g3jcjm 322 59 Associated associate VBN cord-265139-x7g3jcjm 322 60 with with IN cord-265139-x7g3jcjm 322 61 Multiple Multiple NNP cord-265139-x7g3jcjm 322 62 Disease Disease NNP cord-265139-x7g3jcjm 322 63 Phenotypes phenotype NNS cord-265139-x7g3jcjm 322 64 Correlate correlate VBP cord-265139-x7g3jcjm 322 65 with with IN cord-265139-x7g3jcjm 322 66 ANRIL anril JJ cord-265139-x7g3jcjm 322 67 Expression expression NN cord-265139-x7g3jcjm 322 68 ANRIL ANRIL NNP cord-265139-x7g3jcjm 322 69 : : : cord-265139-x7g3jcjm 323 1 Molecular Molecular NNP cord-265139-x7g3jcjm 323 2 Mechanisms Mechanisms NNPS cord-265139-x7g3jcjm 323 3 and and CC cord-265139-x7g3jcjm 323 4 Implications Implications NNPS cord-265139-x7g3jcjm 323 5 in in IN cord-265139-x7g3jcjm 323 6 Human Human NNP cord-265139-x7g3jcjm 323 7 Health Health NNP cord-265139-x7g3jcjm 323 8 Islet Islet NNP cord-265139-x7g3jcjm 323 9 biology biology NN cord-265139-x7g3jcjm 323 10 , , , cord-265139-x7g3jcjm 323 11 the the DT cord-265139-x7g3jcjm 323 12 CDKN2A CDKN2A NNP cord-265139-x7g3jcjm 323 13 / / SYM cord-265139-x7g3jcjm 323 14 B b NN cord-265139-x7g3jcjm 323 15 locus locus NN cord-265139-x7g3jcjm 323 16 and and CC cord-265139-x7g3jcjm 323 17 type type NN cord-265139-x7g3jcjm 323 18 2 2 CD cord-265139-x7g3jcjm 323 19 diabetes diabetes NN cord-265139-x7g3jcjm 323 20 risk risk NN cord-265139-x7g3jcjm 323 21 DNA dna NN cord-265139-x7g3jcjm 323 22 methylation methylation NN cord-265139-x7g3jcjm 323 23 at at IN cord-265139-x7g3jcjm 323 24 birth birth NN cord-265139-x7g3jcjm 323 25 within within IN cord-265139-x7g3jcjm 323 26 the the DT cord-265139-x7g3jcjm 323 27 promoter promoter NN cord-265139-x7g3jcjm 323 28 of of IN cord-265139-x7g3jcjm 323 29 ANRIL ANRIL NNP cord-265139-x7g3jcjm 323 30 predicts predict VBZ cord-265139-x7g3jcjm 323 31 markers marker NNS cord-265139-x7g3jcjm 323 32 of of IN cord-265139-x7g3jcjm 323 33 cardiovascular cardiovascular JJ cord-265139-x7g3jcjm 323 34 risk risk NN cord-265139-x7g3jcjm 323 35 at at IN cord-265139-x7g3jcjm 323 36 9 9 CD cord-265139-x7g3jcjm 323 37 years year NNS cord-265139-x7g3jcjm 323 38 ANRIL ANRIL NNP cord-265139-x7g3jcjm 323 39 Promoter Promoter NNP cord-265139-x7g3jcjm 323 40 DNA DNA NNP cord-265139-x7g3jcjm 323 41 Methylation Methylation NNP cord-265139-x7g3jcjm 323 42 : : : cord-265139-x7g3jcjm 323 43 A a DT cord-265139-x7g3jcjm 323 44 Perinatal perinatal JJ cord-265139-x7g3jcjm 323 45 Marker marker NN cord-265139-x7g3jcjm 323 46 for for IN cord-265139-x7g3jcjm 323 47 Later later JJ cord-265139-x7g3jcjm 323 48 Adiposity Adiposity NNP cord-265139-x7g3jcjm 323 49 Inflammation inflammation NN cord-265139-x7g3jcjm 323 50 and and CC cord-265139-x7g3jcjm 323 51 insulin insulin NN cord-265139-x7g3jcjm 323 52 resistance resistance NN cord-265139-x7g3jcjm 323 53 Macartney Macartney NNP cord-265139-x7g3jcjm 323 54 - - HYPH cord-265139-x7g3jcjm 323 55 Coxson Coxson NNP cord-265139-x7g3jcjm 323 56 , , , cord-265139-x7g3jcjm 323 57 D. D. NNP cord-265139-x7g3jcjm 323 58 miRNA miRNA NNP cord-265139-x7g3jcjm 324 1 Signatures signature NNS cord-265139-x7g3jcjm 324 2 of of IN cord-265139-x7g3jcjm 324 3 Insulin Insulin NNP cord-265139-x7g3jcjm 324 4 Resistance Resistance NNP cord-265139-x7g3jcjm 324 5 in in IN cord-265139-x7g3jcjm 324 6 Obesity obesity NN cord-265139-x7g3jcjm 325 1 MicroRNAs MicroRNAs NNP cord-265139-x7g3jcjm 325 2 103 103 CD cord-265139-x7g3jcjm 325 3 and and CC cord-265139-x7g3jcjm 325 4 107 107 CD cord-265139-x7g3jcjm 325 5 regulate regulate VB cord-265139-x7g3jcjm 325 6 insulin insulin NN cord-265139-x7g3jcjm 325 7 sensitivity sensitivity NN cord-265139-x7g3jcjm 325 8 Genetic genetic JJ cord-265139-x7g3jcjm 325 9 Ablation ablation NN cord-265139-x7g3jcjm 325 10 of of IN cord-265139-x7g3jcjm 325 11 miR-33 mir-33 NN cord-265139-x7g3jcjm 326 1 Increases increase VBZ cord-265139-x7g3jcjm 326 2 Food Food NNP cord-265139-x7g3jcjm 326 3 Intake Intake NNP cord-265139-x7g3jcjm 326 4 , , , cord-265139-x7g3jcjm 326 5 Enhances enhance VBZ cord-265139-x7g3jcjm 326 6 Adipose Adipose NNP cord-265139-x7g3jcjm 326 7 Tissue Tissue NNP cord-265139-x7g3jcjm 326 8 Expansion Expansion NNP cord-265139-x7g3jcjm 326 9 , , , cord-265139-x7g3jcjm 326 10 and and CC cord-265139-x7g3jcjm 326 11 Promotes promote VBZ cord-265139-x7g3jcjm 326 12 Obesity obesity NN cord-265139-x7g3jcjm 326 13 and and CC cord-265139-x7g3jcjm 326 14 Insulin Insulin NNP cord-265139-x7g3jcjm 326 15 Resistance Resistance NNP cord-265139-x7g3jcjm 326 16 Comprehensive Comprehensive NNP cord-265139-x7g3jcjm 326 17 functional functional JJ cord-265139-x7g3jcjm 326 18 screening screening NN cord-265139-x7g3jcjm 326 19 of of IN cord-265139-x7g3jcjm 326 20 miRNAs miRNAs NNP cord-265139-x7g3jcjm 326 21 involved involve VBN cord-265139-x7g3jcjm 326 22 in in IN cord-265139-x7g3jcjm 326 23 fat fat JJ cord-265139-x7g3jcjm 326 24 cell cell NN cord-265139-x7g3jcjm 326 25 insulin insulin NN cord-265139-x7g3jcjm 326 26 sensitivity sensitivity NN cord-265139-x7g3jcjm 326 27 among among IN cord-265139-x7g3jcjm 326 28 women woman NNS cord-265139-x7g3jcjm 326 29 Linking link VBG cord-265139-x7g3jcjm 326 30 a a DT cord-265139-x7g3jcjm 326 31 role role NN cord-265139-x7g3jcjm 326 32 of of IN cord-265139-x7g3jcjm 326 33 lncRNAs lncRNAs NNP cord-265139-x7g3jcjm 326 34 ( ( -LRB- cord-265139-x7g3jcjm 326 35 long long JJ cord-265139-x7g3jcjm 326 36 non non JJ cord-265139-x7g3jcjm 326 37 - - JJ cord-265139-x7g3jcjm 326 38 coding coding JJ cord-265139-x7g3jcjm 326 39 RNAs rna NNS cord-265139-x7g3jcjm 326 40 ) ) -RRB- cord-265139-x7g3jcjm 326 41 with with IN cord-265139-x7g3jcjm 326 42 insulin insulin NN cord-265139-x7g3jcjm 326 43 resistance resistance NN cord-265139-x7g3jcjm 326 44 , , , cord-265139-x7g3jcjm 326 45 accelerated accelerated JJ cord-265139-x7g3jcjm 326 46 senescence senescence NN cord-265139-x7g3jcjm 326 47 , , , cord-265139-x7g3jcjm 326 48 and and CC cord-265139-x7g3jcjm 326 49 inflammation inflammation NN cord-265139-x7g3jcjm 326 50 in in IN cord-265139-x7g3jcjm 326 51 patients patient NNS cord-265139-x7g3jcjm 326 52 with with IN cord-265139-x7g3jcjm 326 53 type type NN cord-265139-x7g3jcjm 326 54 2 2 CD cord-265139-x7g3jcjm 326 55 diabetes diabetes NN cord-265139-x7g3jcjm 326 56 Circular Circular NNP cord-265139-x7g3jcjm 326 57 RNA RNA NNP cord-265139-x7g3jcjm 326 58 HIPK3 hipk3 NN cord-265139-x7g3jcjm 326 59 contributes contribute VBZ cord-265139-x7g3jcjm 326 60 to to IN cord-265139-x7g3jcjm 326 61 hyperglycemia hyperglycemia NN cord-265139-x7g3jcjm 326 62 and and CC cord-265139-x7g3jcjm 326 63 insulin insulin NN cord-265139-x7g3jcjm 326 64 homeostasis homeostasis NN cord-265139-x7g3jcjm 326 65 by by IN cord-265139-x7g3jcjm 326 66 sponging sponge VBG cord-265139-x7g3jcjm 326 67 miR-192 mir-192 NN cord-265139-x7g3jcjm 326 68 - - : cord-265139-x7g3jcjm 326 69 5p 5p NN cord-265139-x7g3jcjm 326 70 and and CC cord-265139-x7g3jcjm 326 71 upregulating upregulate VBG cord-265139-x7g3jcjm 326 72 transcription transcription NN cord-265139-x7g3jcjm 326 73 factor factor NN cord-265139-x7g3jcjm 326 74 forkhead forkhead NNP cord-265139-x7g3jcjm 326 75 box box NNP cord-265139-x7g3jcjm 326 76 O1 O1 NNP cord-265139-x7g3jcjm 326 77 Circular Circular NNP cord-265139-x7g3jcjm 326 78 Noncoding Noncoding NNP cord-265139-x7g3jcjm 326 79 RNA RNA NNP cord-265139-x7g3jcjm 326 80 HIPK3 hipk3 NN cord-265139-x7g3jcjm 327 1 Mediates mediate VBZ cord-265139-x7g3jcjm 327 2 Retinal Retinal NNP cord-265139-x7g3jcjm 327 3 Vascular Vascular NNP cord-265139-x7g3jcjm 327 4 Dysfunction Dysfunction NNP cord-265139-x7g3jcjm 327 5 in in IN cord-265139-x7g3jcjm 327 6 Diabetes Diabetes NNP cord-265139-x7g3jcjm 327 7 Mellitus Mellitus NNP cord-265139-x7g3jcjm 327 8 Genetic genetic JJ cord-265139-x7g3jcjm 327 9 variants variant NNS cord-265139-x7g3jcjm 327 10 including include VBG cord-265139-x7g3jcjm 327 11 markers marker NNS cord-265139-x7g3jcjm 327 12 from from IN cord-265139-x7g3jcjm 327 13 the the DT cord-265139-x7g3jcjm 327 14 exome exome NN cord-265139-x7g3jcjm 327 15 chip chip NN cord-265139-x7g3jcjm 327 16 and and CC cord-265139-x7g3jcjm 327 17 metabolite metabolite JJ cord-265139-x7g3jcjm 327 18 traits trait NNS cord-265139-x7g3jcjm 327 19 of of IN cord-265139-x7g3jcjm 327 20 type type NN cord-265139-x7g3jcjm 327 21 2 2 CD cord-265139-x7g3jcjm 327 22 diabetes diabete VBZ cord-265139-x7g3jcjm 327 23 Inflammatory Inflammatory NNP cord-265139-x7g3jcjm 327 24 Mechanisms Mechanisms NNPS cord-265139-x7g3jcjm 327 25 in in IN cord-265139-x7g3jcjm 327 26 Obesity obesity NN cord-265139-x7g3jcjm 327 27 Adapting adapt VBG cord-265139-x7g3jcjm 327 28 to to IN cord-265139-x7g3jcjm 327 29 obesity obesity NN cord-265139-x7g3jcjm 327 30 with with IN cord-265139-x7g3jcjm 327 31 adipose adipose JJ cord-265139-x7g3jcjm 327 32 tissue tissue NN cord-265139-x7g3jcjm 327 33 inflammation inflammation NN cord-265139-x7g3jcjm 328 1 Novel Novel NNP cord-265139-x7g3jcjm 328 2 Long Long NNP cord-265139-x7g3jcjm 328 3 Noncoding Noncoding NNP cord-265139-x7g3jcjm 328 4 RNA RNA NNP cord-265139-x7g3jcjm 328 5 , , , cord-265139-x7g3jcjm 328 6 Macrophage Macrophage NNP cord-265139-x7g3jcjm 328 7 Inflammation Inflammation NNP cord-265139-x7g3jcjm 328 8 - - HYPH cord-265139-x7g3jcjm 328 9 Suppressing Suppressing NNP cord-265139-x7g3jcjm 328 10 Transcript Transcript NNP cord-265139-x7g3jcjm 328 11 ( ( -LRB- cord-265139-x7g3jcjm 328 12 MIST MIST NNP cord-265139-x7g3jcjm 328 13 ) ) -RRB- cord-265139-x7g3jcjm 328 14 , , , cord-265139-x7g3jcjm 328 15 Regulates regulate VBZ cord-265139-x7g3jcjm 328 16 Macrophage Macrophage NNP cord-265139-x7g3jcjm 328 17 Activation Activation NNP cord-265139-x7g3jcjm 328 18 During during IN cord-265139-x7g3jcjm 328 19 Obesity obesity NN cord-265139-x7g3jcjm 328 20 circARF3 circarf3 NN cord-265139-x7g3jcjm 328 21 Alleviates alleviate VBZ cord-265139-x7g3jcjm 328 22 Mitophagy Mitophagy NNP cord-265139-x7g3jcjm 328 23 - - HYPH cord-265139-x7g3jcjm 328 24 Mediated mediate VBN cord-265139-x7g3jcjm 328 25 Inflammation inflammation NN cord-265139-x7g3jcjm 328 26 by by IN cord-265139-x7g3jcjm 328 27 Targeting target VBG cord-265139-x7g3jcjm 328 28 miR-103 miR-103 NNP cord-265139-x7g3jcjm 328 29 / / SYM cord-265139-x7g3jcjm 328 30 TRAF3 traf3 NN cord-265139-x7g3jcjm 328 31 in in IN cord-265139-x7g3jcjm 328 32 Mouse Mouse NNP cord-265139-x7g3jcjm 328 33 Adipose Adipose NNP cord-265139-x7g3jcjm 328 34 Tissue Tissue NNP cord-265139-x7g3jcjm 328 35 Myeloid Myeloid NNP cord-265139-x7g3jcjm 328 36 cell cell NN cord-265139-x7g3jcjm 329 1 TRAF3 TRAF3 NNP cord-265139-x7g3jcjm 329 2 promotes promote VBZ cord-265139-x7g3jcjm 329 3 metabolic metabolic JJ cord-265139-x7g3jcjm 329 4 inflammation inflammation NN cord-265139-x7g3jcjm 329 5 , , , cord-265139-x7g3jcjm 329 6 insulin insulin NN cord-265139-x7g3jcjm 329 7 resistance resistance NN cord-265139-x7g3jcjm 329 8 , , , cord-265139-x7g3jcjm 329 9 and and CC cord-265139-x7g3jcjm 329 10 hepatic hepatic JJ cord-265139-x7g3jcjm 329 11 steatosis steatosis NN cord-265139-x7g3jcjm 329 12 in in IN cord-265139-x7g3jcjm 329 13 obesity obesity NN cord-265139-x7g3jcjm 329 14 Prevalence prevalence NN cord-265139-x7g3jcjm 329 15 and and CC cord-265139-x7g3jcjm 329 16 Correlates Correlates NNPS cord-265139-x7g3jcjm 329 17 of of IN cord-265139-x7g3jcjm 329 18 Overweight Overweight NNP cord-265139-x7g3jcjm 329 19 and and CC cord-265139-x7g3jcjm 329 20 Obesity obesity NN cord-265139-x7g3jcjm 329 21 Among among IN cord-265139-x7g3jcjm 329 22 Older old JJR cord-265139-x7g3jcjm 329 23 Adults Adults NNPS cord-265139-x7g3jcjm 329 24 : : : cord-265139-x7g3jcjm 330 1 Findings finding NNS cord-265139-x7g3jcjm 330 2 From from IN cord-265139-x7g3jcjm 330 3 the the DT cord-265139-x7g3jcjm 330 4 Canadian Canadian NNP cord-265139-x7g3jcjm 330 5 National National NNP cord-265139-x7g3jcjm 330 6 Population Population NNP cord-265139-x7g3jcjm 330 7 Health Health NNP cord-265139-x7g3jcjm 330 8 Survey Survey NNP cord-265139-x7g3jcjm 330 9 Screening Screening NNP cord-265139-x7g3jcjm 330 10 of of IN cord-265139-x7g3jcjm 330 11 circular circular JJ cord-265139-x7g3jcjm 330 12 RNAs rna NNS cord-265139-x7g3jcjm 330 13 and and CC cord-265139-x7g3jcjm 330 14 validation validation NN cord-265139-x7g3jcjm 330 15 of of IN cord-265139-x7g3jcjm 330 16 circANKRD36 circankrd36 NN cord-265139-x7g3jcjm 330 17 associated associate VBN cord-265139-x7g3jcjm 330 18 with with IN cord-265139-x7g3jcjm 330 19 inflammation inflammation NN cord-265139-x7g3jcjm 330 20 in in IN cord-265139-x7g3jcjm 330 21 patients patient NNS cord-265139-x7g3jcjm 330 22 with with IN cord-265139-x7g3jcjm 330 23 type type NN cord-265139-x7g3jcjm 330 24 2 2 CD cord-265139-x7g3jcjm 330 25 diabetes diabetes NN cord-265139-x7g3jcjm 330 26 mellitus mellitus NN cord-265139-x7g3jcjm 330 27 Diabetes Diabetes NNP cord-265139-x7g3jcjm 330 28 Association Association NNP cord-265139-x7g3jcjm 330 29 Annual Annual NNP cord-265139-x7g3jcjm 330 30 Meeting Meeting NNP cord-265139-x7g3jcjm 330 31 , , , cord-265139-x7g3jcjm 330 32 1999 1999 CD cord-265139-x7g3jcjm 330 33 : : : cord-265139-x7g3jcjm 330 34 diabetes diabetes NN cord-265139-x7g3jcjm 330 35 and and CC cord-265139-x7g3jcjm 330 36 obesity obesity NN cord-265139-x7g3jcjm 331 1 The the DT cord-265139-x7g3jcjm 331 2 different different JJ cord-265139-x7g3jcjm 331 3 shades shade NNS cord-265139-x7g3jcjm 331 4 of of IN cord-265139-x7g3jcjm 331 5 fat fat JJ cord-265139-x7g3jcjm 331 6 Browning Browning NNP cord-265139-x7g3jcjm 331 7 of of IN cord-265139-x7g3jcjm 331 8 white white JJ cord-265139-x7g3jcjm 331 9 fat fat NN cord-265139-x7g3jcjm 331 10 : : : cord-265139-x7g3jcjm 331 11 agents agent NNS cord-265139-x7g3jcjm 331 12 and and CC cord-265139-x7g3jcjm 331 13 implications implication NNS cord-265139-x7g3jcjm 331 14 for for IN cord-265139-x7g3jcjm 331 15 beige beige JJ cord-265139-x7g3jcjm 331 16 adipose adipose JJ cord-265139-x7g3jcjm 331 17 tissue tissue NN cord-265139-x7g3jcjm 331 18 to to IN cord-265139-x7g3jcjm 331 19 type type NN cord-265139-x7g3jcjm 331 20 2 2 CD cord-265139-x7g3jcjm 331 21 diabetes diabete NNS cord-265139-x7g3jcjm 331 22 MicroRNA-455 MicroRNA-455 NNP cord-265139-x7g3jcjm 331 23 regulates regulate VBZ cord-265139-x7g3jcjm 331 24 brown brown JJ cord-265139-x7g3jcjm 331 25 adipogenesis adipogenesis NNP cord-265139-x7g3jcjm 331 26 via via IN cord-265139-x7g3jcjm 331 27 a a DT cord-265139-x7g3jcjm 331 28 novel novel JJ cord-265139-x7g3jcjm 331 29 HIF1an HIF1an NNP cord-265139-x7g3jcjm 331 30 - - HYPH cord-265139-x7g3jcjm 331 31 AMPK AMPK NNP cord-265139-x7g3jcjm 331 32 - - HYPH cord-265139-x7g3jcjm 331 33 PGC1α PGC1α NNP cord-265139-x7g3jcjm 331 34 signaling signal VBG cord-265139-x7g3jcjm 331 35 network network NN cord-265139-x7g3jcjm 331 36 Egr1 Egr1 NNP cord-265139-x7g3jcjm 331 37 deficiency deficiency NN cord-265139-x7g3jcjm 331 38 induces induce VBZ cord-265139-x7g3jcjm 331 39 browning browning NN cord-265139-x7g3jcjm 331 40 of of IN cord-265139-x7g3jcjm 331 41 inguinal inguinal JJ cord-265139-x7g3jcjm 331 42 subcutaneous subcutaneous JJ cord-265139-x7g3jcjm 331 43 white white JJ cord-265139-x7g3jcjm 331 44 adipose adipose JJ cord-265139-x7g3jcjm 331 45 tissue tissue NN cord-265139-x7g3jcjm 331 46 in in IN cord-265139-x7g3jcjm 331 47 mice mouse NNS cord-265139-x7g3jcjm 332 1 Cold Cold NNP cord-265139-x7g3jcjm 332 2 - - HYPH cord-265139-x7g3jcjm 332 3 Induced Induced NNP cord-265139-x7g3jcjm 332 4 Browning Browning NNP cord-265139-x7g3jcjm 332 5 of of IN cord-265139-x7g3jcjm 332 6 Inguinal Inguinal NNP cord-265139-x7g3jcjm 332 7 White White NNP cord-265139-x7g3jcjm 332 8 Adipose Adipose NNP cord-265139-x7g3jcjm 332 9 Tissue Tissue NNP cord-265139-x7g3jcjm 332 10 Is be VBZ cord-265139-x7g3jcjm 332 11 Independent Independent NNP cord-265139-x7g3jcjm 332 12 of of IN cord-265139-x7g3jcjm 332 13 Adipose Adipose NNP cord-265139-x7g3jcjm 332 14 Tissue Tissue NNP cord-265139-x7g3jcjm 333 1 Cyclooxygenase-2 Cyclooxygenase-2 NNP cord-265139-x7g3jcjm 334 1 A. A. NNP cord-265139-x7g3jcjm 334 2 miR-155 miR-155 NNP cord-265139-x7g3jcjm 334 3 regulates regulate VBZ cord-265139-x7g3jcjm 334 4 differentiation differentiation NN cord-265139-x7g3jcjm 334 5 of of IN cord-265139-x7g3jcjm 334 6 brown brown JJ cord-265139-x7g3jcjm 334 7 and and CC cord-265139-x7g3jcjm 334 8 beige beige JJ cord-265139-x7g3jcjm 334 9 adipocytes adipocyte NNS cord-265139-x7g3jcjm 334 10 via via IN cord-265139-x7g3jcjm 334 11 a a DT cord-265139-x7g3jcjm 334 12 bistable bistable JJ cord-265139-x7g3jcjm 334 13 circuit circuit NN cord-265139-x7g3jcjm 334 14 De de FW cord-265139-x7g3jcjm 334 15 novo novo NNP cord-265139-x7g3jcjm 334 16 reconstruction reconstruction NN cord-265139-x7g3jcjm 334 17 of of IN cord-265139-x7g3jcjm 334 18 human human JJ cord-265139-x7g3jcjm 334 19 adipose adipose NNP cord-265139-x7g3jcjm 334 20 transcriptome transcriptome NN cord-265139-x7g3jcjm 334 21 reveals reveal VBZ cord-265139-x7g3jcjm 334 22 conserved conserve VBN cord-265139-x7g3jcjm 334 23 lncRNAs lncRNAs NNP cord-265139-x7g3jcjm 334 24 as as IN cord-265139-x7g3jcjm 334 25 regulators regulator NNS cord-265139-x7g3jcjm 334 26 of of IN cord-265139-x7g3jcjm 334 27 brown brown JJ cord-265139-x7g3jcjm 334 28 adipogenesis adipogenesis NNP cord-265139-x7g3jcjm 335 1 Exosomal Exosomal NNP cord-265139-x7g3jcjm 335 2 circRNA circrna RB cord-265139-x7g3jcjm 335 3 derived derive VBN cord-265139-x7g3jcjm 335 4 from from IN cord-265139-x7g3jcjm 335 5 gastric gastric JJ cord-265139-x7g3jcjm 335 6 tumor tumor NN cord-265139-x7g3jcjm 335 7 promotes promote VBZ cord-265139-x7g3jcjm 335 8 white white JJ cord-265139-x7g3jcjm 335 9 adipose adipose JJ cord-265139-x7g3jcjm 335 10 browning browning NN cord-265139-x7g3jcjm 335 11 by by IN cord-265139-x7g3jcjm 335 12 targeting target VBG cord-265139-x7g3jcjm 335 13 the the DT cord-265139-x7g3jcjm 335 14 miR-133 miR-133 NNP cord-265139-x7g3jcjm 335 15 / / SYM cord-265139-x7g3jcjm 335 16 PRDM16 PRDM16 NNP cord-265139-x7g3jcjm 335 17 pathway pathway NN cord-265139-x7g3jcjm 335 18 circNrxn2 circNrxn2 NNP cord-265139-x7g3jcjm 336 1 Promoted promote VBN cord-265139-x7g3jcjm 336 2 WAT WAT NNP cord-265139-x7g3jcjm 336 3 Browning Browning NNP cord-265139-x7g3jcjm 336 4 via via IN cord-265139-x7g3jcjm 336 5 Sponging sponge VBG cord-265139-x7g3jcjm 336 6 miR-103 mir-103 NN cord-265139-x7g3jcjm 336 7 to to TO cord-265139-x7g3jcjm 336 8 Relieve relieve VB cord-265139-x7g3jcjm 336 9 Its -PRON- PRP$ cord-265139-x7g3jcjm 336 10 Inhibition inhibition NN cord-265139-x7g3jcjm 336 11 of of IN cord-265139-x7g3jcjm 336 12 FGF10 FGF10 NNPS cord-265139-x7g3jcjm 336 13 in in IN cord-265139-x7g3jcjm 336 14 HFD HFD NNP cord-265139-x7g3jcjm 337 1 Mice Mice NNP cord-265139-x7g3jcjm 337 2 Dynamic dynamic JJ cord-265139-x7g3jcjm 337 3 cross cross NN cord-265139-x7g3jcjm 337 4 talk talk NN cord-265139-x7g3jcjm 337 5 between between IN cord-265139-x7g3jcjm 337 6 metabolic metabolic JJ cord-265139-x7g3jcjm 337 7 organs organ NNS cord-265139-x7g3jcjm 337 8 in in IN cord-265139-x7g3jcjm 337 9 obesity obesity NN cord-265139-x7g3jcjm 337 10 and and CC cord-265139-x7g3jcjm 337 11 metabolic metabolic JJ cord-265139-x7g3jcjm 337 12 diseases disease NNS cord-265139-x7g3jcjm 338 1 Adipose adipose NN cord-265139-x7g3jcjm 338 2 - - HYPH cord-265139-x7g3jcjm 338 3 derived derive VBN cord-265139-x7g3jcjm 338 4 circulating circulate VBG cord-265139-x7g3jcjm 338 5 miRNAs miRNAs NNP cord-265139-x7g3jcjm 338 6 regulate regulate VB cord-265139-x7g3jcjm 338 7 gene gene NN cord-265139-x7g3jcjm 338 8 expression expression NN cord-265139-x7g3jcjm 338 9 in in IN cord-265139-x7g3jcjm 338 10 other other JJ cord-265139-x7g3jcjm 338 11 tissues tissue NNS cord-265139-x7g3jcjm 339 1 Adipose Adipose NNP cord-265139-x7g3jcjm 339 2 Tissue tissue NN cord-265139-x7g3jcjm 340 1 Macrophage macrophage NN cord-265139-x7g3jcjm 340 2 - - HYPH cord-265139-x7g3jcjm 340 3 Derived derive VBN cord-265139-x7g3jcjm 340 4 Exosomal Exosomal NNP cord-265139-x7g3jcjm 340 5 miRNAs mirnas NN cord-265139-x7g3jcjm 340 6 Can Can MD cord-265139-x7g3jcjm 340 7 Modulate modulate VB cord-265139-x7g3jcjm 340 8 In in IN cord-265139-x7g3jcjm 340 9 Vivo Vivo NNP cord-265139-x7g3jcjm 340 10 and and CC cord-265139-x7g3jcjm 340 11 In in IN cord-265139-x7g3jcjm 340 12 Vitro Vitro NNP cord-265139-x7g3jcjm 340 13 Insulin Insulin NNP cord-265139-x7g3jcjm 340 14 Sensitivity Sensitivity NNP cord-265139-x7g3jcjm 340 15 Exosome Exosome NNP cord-265139-x7g3jcjm 340 16 - - HYPH cord-265139-x7g3jcjm 340 17 mediated mediate VBN cord-265139-x7g3jcjm 340 18 transfer transfer NN cord-265139-x7g3jcjm 340 19 of of IN cord-265139-x7g3jcjm 340 20 mRNAs mrnas CD cord-265139-x7g3jcjm 341 1 and and CC cord-265139-x7g3jcjm 341 2 microRNAs microRNAs NNPS cord-265139-x7g3jcjm 341 3 is be VBZ cord-265139-x7g3jcjm 341 4 a a DT cord-265139-x7g3jcjm 341 5 novel novel JJ cord-265139-x7g3jcjm 341 6 mechanism mechanism NN cord-265139-x7g3jcjm 341 7 of of IN cord-265139-x7g3jcjm 341 8 genetic genetic JJ cord-265139-x7g3jcjm 341 9 exchange exchange NN cord-265139-x7g3jcjm 341 10 between between IN cord-265139-x7g3jcjm 341 11 cells cell NNS cord-265139-x7g3jcjm 342 1 Adipose Adipose NNP cord-265139-x7g3jcjm 342 2 Tissue tissue NN cord-265139-x7g3jcjm 343 1 Exosome Exosome NNP cord-265139-x7g3jcjm 343 2 - - HYPH cord-265139-x7g3jcjm 343 3 Like like JJ cord-265139-x7g3jcjm 344 1 Vesicles Vesicles NNP cord-265139-x7g3jcjm 344 2 Mediate Mediate NNP cord-265139-x7g3jcjm 344 3 Activation Activation NNP cord-265139-x7g3jcjm 344 4 of of IN cord-265139-x7g3jcjm 344 5 Macrophage Macrophage NNP cord-265139-x7g3jcjm 344 6 - - HYPH cord-265139-x7g3jcjm 344 7 Induced induce VBN cord-265139-x7g3jcjm 344 8 Insulin Insulin NNP cord-265139-x7g3jcjm 344 9 Resistance Resistance NNP cord-265139-x7g3jcjm 344 10 Exosome Exosome NNP cord-265139-x7g3jcjm 344 11 circRNA circrna NN cord-265139-x7g3jcjm 344 12 secreted secrete VBN cord-265139-x7g3jcjm 344 13 from from IN cord-265139-x7g3jcjm 344 14 adipocytes adipocyte NNS cord-265139-x7g3jcjm 344 15 promotes promote VBZ cord-265139-x7g3jcjm 344 16 the the DT cord-265139-x7g3jcjm 344 17 growth growth NN cord-265139-x7g3jcjm 344 18 of of IN cord-265139-x7g3jcjm 344 19 hepatocellular hepatocellular JJ cord-265139-x7g3jcjm 344 20 carcinoma carcinoma NN cord-265139-x7g3jcjm 344 21 by by IN cord-265139-x7g3jcjm 344 22 targeting target VBG cord-265139-x7g3jcjm 344 23 deubiquitination deubiquitination NN cord-265139-x7g3jcjm 344 24 - - HYPH cord-265139-x7g3jcjm 344 25 related relate VBN cord-265139-x7g3jcjm 344 26 USP7 USP7 NNP cord-265139-x7g3jcjm 344 27 Circular Circular NNP cord-265139-x7g3jcjm 344 28 RNA RNA NNP cord-265139-x7g3jcjm 344 29 is be VBZ cord-265139-x7g3jcjm 344 30 enriched enrich VBN cord-265139-x7g3jcjm 344 31 and and CC cord-265139-x7g3jcjm 344 32 stable stable JJ cord-265139-x7g3jcjm 344 33 in in IN cord-265139-x7g3jcjm 344 34 exosomes exosome NNS cord-265139-x7g3jcjm 344 35 : : : cord-265139-x7g3jcjm 345 1 A a DT cord-265139-x7g3jcjm 345 2 promising promising JJ cord-265139-x7g3jcjm 345 3 biomarker biomarker NN cord-265139-x7g3jcjm 345 4 for for IN cord-265139-x7g3jcjm 345 5 cancer cancer NN cord-265139-x7g3jcjm 345 6 diagnosis diagnosis NN cord-265139-x7g3jcjm 346 1 RNA rna NN cord-265139-x7g3jcjm 346 2 - - HYPH cord-265139-x7g3jcjm 346 3 binding bind VBG cord-265139-x7g3jcjm 346 4 protein protein NN cord-265139-x7g3jcjm 346 5 PSPC1 PSPC1 NNP cord-265139-x7g3jcjm 346 6 promotes promote VBZ cord-265139-x7g3jcjm 346 7 the the DT cord-265139-x7g3jcjm 346 8 differentiation differentiation NN cord-265139-x7g3jcjm 346 9 - - HYPH cord-265139-x7g3jcjm 346 10 dependent dependent JJ cord-265139-x7g3jcjm 346 11 nuclear nuclear JJ cord-265139-x7g3jcjm 346 12 export export NN cord-265139-x7g3jcjm 346 13 of of IN cord-265139-x7g3jcjm 346 14 adipocyte adipocyte NN cord-265139-x7g3jcjm 346 15 RNAs rna NNS cord-265139-x7g3jcjm 346 16 KSRP KSRP NNP cord-265139-x7g3jcjm 346 17 Ablation Ablation NNP cord-265139-x7g3jcjm 346 18 Enhances enhance VBZ cord-265139-x7g3jcjm 346 19 Brown Brown NNP cord-265139-x7g3jcjm 346 20 Fat Fat NNP cord-265139-x7g3jcjm 346 21 Gene Gene NNP cord-265139-x7g3jcjm 346 22 Program Program NNP cord-265139-x7g3jcjm 346 23 in in IN cord-265139-x7g3jcjm 346 24 White White NNP cord-265139-x7g3jcjm 346 25 Adipose Adipose NNP cord-265139-x7g3jcjm 346 26 Tissue Tissue NNP cord-265139-x7g3jcjm 346 27 Through through IN cord-265139-x7g3jcjm 346 28 Reduced reduced JJ cord-265139-x7g3jcjm 346 29 miR-150 mir-150 NN cord-265139-x7g3jcjm 346 30 Expression Expression NNP cord-265139-x7g3jcjm 346 31 IGF2BP2 igf2bp2 CD cord-265139-x7g3jcjm 347 1 / / NFP cord-265139-x7g3jcjm 348 1 IMP2-Deficient imp2-deficient JJ cord-265139-x7g3jcjm 348 2 Mice mouse NNS cord-265139-x7g3jcjm 348 3 Resist resist VBP cord-265139-x7g3jcjm 348 4 Obesity obesity NN cord-265139-x7g3jcjm 348 5 through through IN cord-265139-x7g3jcjm 348 6 Enhanced enhanced JJ cord-265139-x7g3jcjm 348 7 Translation translation NN cord-265139-x7g3jcjm 348 8 of of IN cord-265139-x7g3jcjm 348 9 Ucp1 Ucp1 NNP cord-265139-x7g3jcjm 348 10 mRNA mrna NN cord-265139-x7g3jcjm 348 11 and and CC cord-265139-x7g3jcjm 349 1 Other other JJ cord-265139-x7g3jcjm 349 2 mRNAs mRNAs NNPS cord-265139-x7g3jcjm 350 1 Encoding encode VBG cord-265139-x7g3jcjm 350 2 Mitochondrial Mitochondrial NNP cord-265139-x7g3jcjm 350 3 Proteins Proteins NNP cord-265139-x7g3jcjm 350 4 Adipose Adipose NNP cord-265139-x7g3jcjm 350 5 HuR hur NN cord-265139-x7g3jcjm 350 6 protects protect VBZ cord-265139-x7g3jcjm 350 7 against against IN cord-265139-x7g3jcjm 350 8 diet diet NN cord-265139-x7g3jcjm 350 9 - - HYPH cord-265139-x7g3jcjm 350 10 induced induce VBN cord-265139-x7g3jcjm 350 11 obesity obesity NN cord-265139-x7g3jcjm 350 12 and and CC cord-265139-x7g3jcjm 350 13 insulin insulin NN cord-265139-x7g3jcjm 350 14 resistance resistance NN cord-265139-x7g3jcjm 351 1 The the DT cord-265139-x7g3jcjm 351 2 RNA RNA NNP cord-265139-x7g3jcjm 351 3 - - HYPH cord-265139-x7g3jcjm 351 4 binding bind VBG cord-265139-x7g3jcjm 351 5 protein protein NN cord-265139-x7g3jcjm 351 6 HuR hur NN cord-265139-x7g3jcjm 351 7 is be VBZ cord-265139-x7g3jcjm 351 8 a a DT cord-265139-x7g3jcjm 351 9 negative negative JJ cord-265139-x7g3jcjm 351 10 regulator regulator NN cord-265139-x7g3jcjm 351 11 in in IN cord-265139-x7g3jcjm 351 12 adipogenesis adipogenesis NNP cord-265139-x7g3jcjm 352 1 This this DT cord-265139-x7g3jcjm 352 2 article article NN cord-265139-x7g3jcjm 352 3 is be VBZ cord-265139-x7g3jcjm 352 4 an an DT cord-265139-x7g3jcjm 352 5 open open JJ cord-265139-x7g3jcjm 352 6 access access NN cord-265139-x7g3jcjm 352 7 article article NN cord-265139-x7g3jcjm 352 8 distributed distribute VBN cord-265139-x7g3jcjm 352 9 under under IN cord-265139-x7g3jcjm 352 10 the the DT cord-265139-x7g3jcjm 352 11 terms term NNS cord-265139-x7g3jcjm 352 12 and and CC cord-265139-x7g3jcjm 352 13 conditions condition NNS cord-265139-x7g3jcjm 352 14 of of IN cord-265139-x7g3jcjm 352 15 the the DT cord-265139-x7g3jcjm 352 16 Creative Creative NNP cord-265139-x7g3jcjm 352 17 Commons Commons NNP cord-265139-x7g3jcjm 352 18 Attribution Attribution NNP cord-265139-x7g3jcjm 352 19 ( ( -LRB- cord-265139-x7g3jcjm 352 20 CC CC NNP cord-265139-x7g3jcjm 352 21 BY by IN cord-265139-x7g3jcjm 352 22 ) ) -RRB- cord-265139-x7g3jcjm 352 23 license license NN