id sid tid token lemma pos cord-333368-kjrk8nn9 1 1 key key JJ cord-333368-kjrk8nn9 1 2 : : : cord-333368-kjrk8nn9 1 3 cord-333368-kjrk8nn9 cord-333368-kjrk8nn9 JJ cord-333368-kjrk8nn9 1 4 authors author NNS cord-333368-kjrk8nn9 1 5 : : : cord-333368-kjrk8nn9 2 1 Huizinga Huizinga NNP cord-333368-kjrk8nn9 2 2 , , , cord-333368-kjrk8nn9 2 3 Gabrielle Gabrielle NNP cord-333368-kjrk8nn9 2 4 P P NNP cord-333368-kjrk8nn9 2 5 ; ; : cord-333368-kjrk8nn9 2 6 Singer singer NN cord-333368-kjrk8nn9 2 7 , , , cord-333368-kjrk8nn9 2 8 Benjamin Benjamin NNP cord-333368-kjrk8nn9 2 9 H H NNP cord-333368-kjrk8nn9 2 10 ; ; : cord-333368-kjrk8nn9 2 11 Singer Singer NNP cord-333368-kjrk8nn9 2 12 , , , cord-333368-kjrk8nn9 2 13 Kanakadurga Kanakadurga NNP cord-333368-kjrk8nn9 2 14 title title NN cord-333368-kjrk8nn9 2 15 : : : cord-333368-kjrk8nn9 2 16 The the DT cord-333368-kjrk8nn9 2 17 Collision Collision NNP cord-333368-kjrk8nn9 2 18 of of IN cord-333368-kjrk8nn9 2 19 Meta Meta NNP cord-333368-kjrk8nn9 2 20 - - HYPH cord-333368-kjrk8nn9 2 21 Inflammation Inflammation NNP cord-333368-kjrk8nn9 2 22 and and CC cord-333368-kjrk8nn9 2 23 SARS SARS NNP cord-333368-kjrk8nn9 2 24 - - HYPH cord-333368-kjrk8nn9 2 25 CoV-2 CoV-2 NNP cord-333368-kjrk8nn9 2 26 Pandemic Pandemic NNP cord-333368-kjrk8nn9 2 27 Infection infection NN cord-333368-kjrk8nn9 2 28 date date NN cord-333368-kjrk8nn9 2 29 : : : cord-333368-kjrk8nn9 2 30 2020 2020 CD cord-333368-kjrk8nn9 2 31 - - HYPH cord-333368-kjrk8nn9 2 32 09 09 CD cord-333368-kjrk8nn9 2 33 - - HYPH cord-333368-kjrk8nn9 2 34 03 03 CD cord-333368-kjrk8nn9 2 35 journal journal NN cord-333368-kjrk8nn9 2 36 : : : cord-333368-kjrk8nn9 3 1 Endocrinology Endocrinology NNP cord-333368-kjrk8nn9 3 2 DOI DOI NNP cord-333368-kjrk8nn9 3 3 : : : cord-333368-kjrk8nn9 3 4 10.1210 10.1210 NNP cord-333368-kjrk8nn9 3 5 / / SYM cord-333368-kjrk8nn9 3 6 endocr endocr NNP cord-333368-kjrk8nn9 3 7 / / SYM cord-333368-kjrk8nn9 3 8 bqaa154 bqaa154 NNP cord-333368-kjrk8nn9 3 9 sha sha NNP cord-333368-kjrk8nn9 3 10 : : : cord-333368-kjrk8nn9 3 11 1723e7c27aadbc83619fd69629fcc089e700418b 1723e7c27aadbc83619fd69629fcc089e700418b CD cord-333368-kjrk8nn9 3 12 doc_id doc_id CD cord-333368-kjrk8nn9 3 13 : : : cord-333368-kjrk8nn9 3 14 333368 333368 CD cord-333368-kjrk8nn9 3 15 cord_uid cord_uid NNS cord-333368-kjrk8nn9 3 16 : : : cord-333368-kjrk8nn9 4 1 kjrk8nn9 kjrk8nn9 . cord-333368-kjrk8nn9 5 1 The the DT cord-333368-kjrk8nn9 5 2 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 5 3 pandemic pandemic NN cord-333368-kjrk8nn9 5 4 has have VBZ cord-333368-kjrk8nn9 5 5 forced force VBN cord-333368-kjrk8nn9 5 6 us -PRON- PRP cord-333368-kjrk8nn9 5 7 to to TO cord-333368-kjrk8nn9 5 8 consider consider VB cord-333368-kjrk8nn9 5 9 the the DT cord-333368-kjrk8nn9 5 10 physiologic physiologic JJ cord-333368-kjrk8nn9 5 11 role role NN cord-333368-kjrk8nn9 5 12 of of IN cord-333368-kjrk8nn9 5 13 obesity obesity NN cord-333368-kjrk8nn9 5 14 in in IN cord-333368-kjrk8nn9 5 15 the the DT cord-333368-kjrk8nn9 5 16 response response NN cord-333368-kjrk8nn9 5 17 to to IN cord-333368-kjrk8nn9 5 18 infectious infectious JJ cord-333368-kjrk8nn9 5 19 disease disease NN cord-333368-kjrk8nn9 5 20 . . . cord-333368-kjrk8nn9 6 1 There there EX cord-333368-kjrk8nn9 6 2 are be VBP cord-333368-kjrk8nn9 6 3 significant significant JJ cord-333368-kjrk8nn9 6 4 disparities disparity NNS cord-333368-kjrk8nn9 6 5 in in IN cord-333368-kjrk8nn9 6 6 morbidity morbidity NN cord-333368-kjrk8nn9 6 7 and and CC cord-333368-kjrk8nn9 6 8 mortality mortality NN cord-333368-kjrk8nn9 6 9 by by IN cord-333368-kjrk8nn9 6 10 sex sex NN cord-333368-kjrk8nn9 6 11 , , , cord-333368-kjrk8nn9 6 12 weight weight NN cord-333368-kjrk8nn9 6 13 and and CC cord-333368-kjrk8nn9 6 14 diabetes diabetes NN cord-333368-kjrk8nn9 6 15 status status NN cord-333368-kjrk8nn9 6 16 . . . cord-333368-kjrk8nn9 7 1 Numerous numerous JJ cord-333368-kjrk8nn9 7 2 endocrine endocrine JJ cord-333368-kjrk8nn9 7 3 changes change NNS cord-333368-kjrk8nn9 7 4 might may MD cord-333368-kjrk8nn9 7 5 drive drive VB cord-333368-kjrk8nn9 7 6 these these DT cord-333368-kjrk8nn9 7 7 varied varied JJ cord-333368-kjrk8nn9 7 8 responses response NNS cord-333368-kjrk8nn9 7 9 to to IN cord-333368-kjrk8nn9 7 10 SARS SARS NNP cord-333368-kjrk8nn9 7 11 - - HYPH cord-333368-kjrk8nn9 7 12 CoV-2 CoV-2 NNP cord-333368-kjrk8nn9 7 13 infection infection NN cord-333368-kjrk8nn9 7 14 including include VBG cord-333368-kjrk8nn9 7 15 hormone hormone NN cord-333368-kjrk8nn9 7 16 and and CC cord-333368-kjrk8nn9 7 17 immune immune JJ cord-333368-kjrk8nn9 7 18 mediators mediator NNS cord-333368-kjrk8nn9 7 19 , , , cord-333368-kjrk8nn9 7 20 hyperglycemia hyperglycemia NN cord-333368-kjrk8nn9 7 21 , , , cord-333368-kjrk8nn9 7 22 leukocyte leukocyte NN cord-333368-kjrk8nn9 7 23 responses response NNS cord-333368-kjrk8nn9 7 24 , , , cord-333368-kjrk8nn9 7 25 cytokine cytokine JJ cord-333368-kjrk8nn9 7 26 secretion secretion NN cord-333368-kjrk8nn9 7 27 , , , cord-333368-kjrk8nn9 7 28 and and CC cord-333368-kjrk8nn9 7 29 tissue tissue NN cord-333368-kjrk8nn9 7 30 dysfunction dysfunction NN cord-333368-kjrk8nn9 7 31 . . . cord-333368-kjrk8nn9 8 1 Studies study NNS cord-333368-kjrk8nn9 8 2 of of IN cord-333368-kjrk8nn9 8 3 patients patient NNS cord-333368-kjrk8nn9 8 4 with with IN cord-333368-kjrk8nn9 8 5 severe severe JJ cord-333368-kjrk8nn9 8 6 COVID-19 covid-19 JJ cord-333368-kjrk8nn9 8 7 disease disease NN cord-333368-kjrk8nn9 8 8 have have VBP cord-333368-kjrk8nn9 8 9 revealed reveal VBN cord-333368-kjrk8nn9 8 10 the the DT cord-333368-kjrk8nn9 8 11 importance importance NN cord-333368-kjrk8nn9 8 12 of of IN cord-333368-kjrk8nn9 8 13 innate innate JJ cord-333368-kjrk8nn9 8 14 immune immune JJ cord-333368-kjrk8nn9 8 15 responses response NNS cord-333368-kjrk8nn9 8 16 in in IN cord-333368-kjrk8nn9 8 17 driving drive VBG cord-333368-kjrk8nn9 8 18 immunopathology immunopathology NN cord-333368-kjrk8nn9 8 19 and and CC cord-333368-kjrk8nn9 8 20 tissue tissue NN cord-333368-kjrk8nn9 8 21 injury injury NN cord-333368-kjrk8nn9 8 22 . . . cord-333368-kjrk8nn9 9 1 In in IN cord-333368-kjrk8nn9 9 2 this this DT cord-333368-kjrk8nn9 9 3 review review NN cord-333368-kjrk8nn9 9 4 we -PRON- PRP cord-333368-kjrk8nn9 9 5 will will MD cord-333368-kjrk8nn9 9 6 describe describe VB cord-333368-kjrk8nn9 9 7 the the DT cord-333368-kjrk8nn9 9 8 impact impact NN cord-333368-kjrk8nn9 9 9 of of IN cord-333368-kjrk8nn9 9 10 the the DT cord-333368-kjrk8nn9 9 11 metabolically metabolically RB cord-333368-kjrk8nn9 9 12 induced induce VBN cord-333368-kjrk8nn9 9 13 inflammation inflammation NN cord-333368-kjrk8nn9 9 14 ( ( -LRB- cord-333368-kjrk8nn9 9 15 meta meta JJ cord-333368-kjrk8nn9 9 16 - - HYPH cord-333368-kjrk8nn9 9 17 inflammation inflammation NN cord-333368-kjrk8nn9 9 18 ) ) -RRB- cord-333368-kjrk8nn9 9 19 that that WDT cord-333368-kjrk8nn9 9 20 characterizes characterize VBZ cord-333368-kjrk8nn9 9 21 obesity obesity NN cord-333368-kjrk8nn9 9 22 on on IN cord-333368-kjrk8nn9 9 23 innate innate JJ cord-333368-kjrk8nn9 9 24 immunity immunity NN cord-333368-kjrk8nn9 9 25 . . . cord-333368-kjrk8nn9 10 1 We -PRON- PRP cord-333368-kjrk8nn9 10 2 consider consider VBP cord-333368-kjrk8nn9 10 3 that that IN cord-333368-kjrk8nn9 10 4 obesity obesity NN cord-333368-kjrk8nn9 10 5 - - HYPH cord-333368-kjrk8nn9 10 6 driven drive VBN cord-333368-kjrk8nn9 10 7 dysregulation dysregulation NN cord-333368-kjrk8nn9 10 8 of of IN cord-333368-kjrk8nn9 10 9 innate innate JJ cord-333368-kjrk8nn9 10 10 immune immune JJ cord-333368-kjrk8nn9 10 11 responses response NNS cord-333368-kjrk8nn9 10 12 may may MD cord-333368-kjrk8nn9 10 13 drive drive VB cord-333368-kjrk8nn9 10 14 organ organ NN cord-333368-kjrk8nn9 10 15 injury injury NN cord-333368-kjrk8nn9 10 16 in in IN cord-333368-kjrk8nn9 10 17 development development NN cord-333368-kjrk8nn9 10 18 of of IN cord-333368-kjrk8nn9 10 19 severe severe JJ cord-333368-kjrk8nn9 10 20 COVID-19 covid-19 NN cord-333368-kjrk8nn9 10 21 and and CC cord-333368-kjrk8nn9 10 22 impair impair VB cord-333368-kjrk8nn9 10 23 viral viral JJ cord-333368-kjrk8nn9 10 24 clearance clearance NN cord-333368-kjrk8nn9 10 25 . . . cord-333368-kjrk8nn9 11 1 The the DT cord-333368-kjrk8nn9 11 2 chronic chronic JJ cord-333368-kjrk8nn9 11 3 obesity obesity NN cord-333368-kjrk8nn9 11 4 - - HYPH cord-333368-kjrk8nn9 11 5 induced induce VBN cord-333368-kjrk8nn9 11 6 inflammation inflammation NN cord-333368-kjrk8nn9 11 7 characterized characterize VBN cord-333368-kjrk8nn9 11 8 by by IN cord-333368-kjrk8nn9 11 9 increased increase VBN cord-333368-kjrk8nn9 11 10 tissue tissue NN cord-333368-kjrk8nn9 11 11 and and CC cord-333368-kjrk8nn9 11 12 circulating circulate VBG cord-333368-kjrk8nn9 11 13 myeloid myeloid NN cord-333368-kjrk8nn9 11 14 cells cell NNS cord-333368-kjrk8nn9 11 15 has have VBZ cord-333368-kjrk8nn9 11 16 been be VBN cord-333368-kjrk8nn9 11 17 termed term VBN cord-333368-kjrk8nn9 11 18 metabolic metabolic JJ cord-333368-kjrk8nn9 11 19 inflammation inflammation NN cord-333368-kjrk8nn9 11 20 or or CC cord-333368-kjrk8nn9 11 21 meta meta NN cord-333368-kjrk8nn9 11 22 - - HYPH cord-333368-kjrk8nn9 11 23 inflammation inflammation NN cord-333368-kjrk8nn9 11 24 . . . cord-333368-kjrk8nn9 12 1 The the DT cord-333368-kjrk8nn9 12 2 coronavirus coronavirus NN cord-333368-kjrk8nn9 12 3 disease disease NN cord-333368-kjrk8nn9 12 4 2019 2019 CD cord-333368-kjrk8nn9 12 5 pandemic pandemic NN cord-333368-kjrk8nn9 12 6 has have VBZ cord-333368-kjrk8nn9 12 7 highlighted highlight VBN cord-333368-kjrk8nn9 12 8 the the DT cord-333368-kjrk8nn9 12 9 endocrine endocrine JJ cord-333368-kjrk8nn9 12 10 manifestations manifestation NNS cord-333368-kjrk8nn9 12 11 of of IN cord-333368-kjrk8nn9 12 12 obesity obesity NN cord-333368-kjrk8nn9 12 13 and and CC cord-333368-kjrk8nn9 12 14 impact impact NN cord-333368-kjrk8nn9 12 15 of of IN cord-333368-kjrk8nn9 12 16 diabetes diabetes NN cord-333368-kjrk8nn9 12 17 and and CC cord-333368-kjrk8nn9 12 18 obesity obesity NN cord-333368-kjrk8nn9 12 19 on on IN cord-333368-kjrk8nn9 12 20 immune immune JJ cord-333368-kjrk8nn9 12 21 responses response NNS cord-333368-kjrk8nn9 12 22 to to IN cord-333368-kjrk8nn9 12 23 infectious infectious JJ cord-333368-kjrk8nn9 12 24 disease disease NN cord-333368-kjrk8nn9 12 25 . . . cord-333368-kjrk8nn9 13 1 Obesity obesity NN cord-333368-kjrk8nn9 13 2 and and CC cord-333368-kjrk8nn9 13 3 metabolic metabolic JJ cord-333368-kjrk8nn9 13 4 syndrome syndrome NN cord-333368-kjrk8nn9 13 5 have have VBP cord-333368-kjrk8nn9 13 6 been be VBN cord-333368-kjrk8nn9 13 7 identified identify VBN cord-333368-kjrk8nn9 13 8 as as IN cord-333368-kjrk8nn9 13 9 risk risk NN cord-333368-kjrk8nn9 13 10 factors factor NNS cord-333368-kjrk8nn9 13 11 for for IN cord-333368-kjrk8nn9 13 12 severe severe JJ cord-333368-kjrk8nn9 13 13 manifestations manifestation NNS cord-333368-kjrk8nn9 13 14 of of IN cord-333368-kjrk8nn9 13 15 SARS SARS NNP cord-333368-kjrk8nn9 13 16 - - HYPH cord-333368-kjrk8nn9 13 17 CoV-2 CoV-2 NNP cord-333368-kjrk8nn9 13 18 infection infection NN cord-333368-kjrk8nn9 13 19 1 1 CD cord-333368-kjrk8nn9 13 20 , , , cord-333368-kjrk8nn9 13 21 2 2 CD cord-333368-kjrk8nn9 13 22 . . . cord-333368-kjrk8nn9 14 1 Prior prior JJ cord-333368-kjrk8nn9 14 2 studies study NNS cord-333368-kjrk8nn9 14 3 of of IN cord-333368-kjrk8nn9 14 4 the the DT cord-333368-kjrk8nn9 14 5 epidemiology epidemiology NN cord-333368-kjrk8nn9 14 6 of of IN cord-333368-kjrk8nn9 14 7 sepsis sepsis NN cord-333368-kjrk8nn9 14 8 , , , cord-333368-kjrk8nn9 14 9 the the DT cord-333368-kjrk8nn9 14 10 acute acute JJ cord-333368-kjrk8nn9 14 11 respiratory respiratory JJ cord-333368-kjrk8nn9 14 12 distress distress NN cord-333368-kjrk8nn9 14 13 syndrome syndrome NN cord-333368-kjrk8nn9 14 14 ( ( -LRB- cord-333368-kjrk8nn9 14 15 ARDS ARDS NNP cord-333368-kjrk8nn9 14 16 ) ) -RRB- cord-333368-kjrk8nn9 14 17 , , , cord-333368-kjrk8nn9 14 18 and and CC cord-333368-kjrk8nn9 14 19 other other JJ cord-333368-kjrk8nn9 14 20 acute acute JJ cord-333368-kjrk8nn9 14 21 illnesses illness NNS cord-333368-kjrk8nn9 14 22 have have VBP cord-333368-kjrk8nn9 14 23 raised raise VBN cord-333368-kjrk8nn9 14 24 the the DT cord-333368-kjrk8nn9 14 25 question question NN cord-333368-kjrk8nn9 14 26 of of IN cord-333368-kjrk8nn9 14 27 whether whether IN cord-333368-kjrk8nn9 14 28 obesity obesity NN cord-333368-kjrk8nn9 14 29 is be VBZ cord-333368-kjrk8nn9 14 30 associated associate VBN cord-333368-kjrk8nn9 14 31 with with IN cord-333368-kjrk8nn9 14 32 lower low JJR cord-333368-kjrk8nn9 14 33 mortality mortality NN cord-333368-kjrk8nn9 14 34 in in IN cord-333368-kjrk8nn9 14 35 critical critical JJ cord-333368-kjrk8nn9 14 36 illness illness NN cord-333368-kjrk8nn9 14 37 -the -the ADD cord-333368-kjrk8nn9 14 38 " " '' cord-333368-kjrk8nn9 14 39 obesity obesity NN cord-333368-kjrk8nn9 14 40 paradox paradox NN cord-333368-kjrk8nn9 14 41 " " '' cord-333368-kjrk8nn9 14 42 3 3 CD cord-333368-kjrk8nn9 14 43 , , , cord-333368-kjrk8nn9 14 44 4 4 CD cord-333368-kjrk8nn9 14 45 . . . cord-333368-kjrk8nn9 15 1 However however RB cord-333368-kjrk8nn9 15 2 , , , cord-333368-kjrk8nn9 15 3 the the DT cord-333368-kjrk8nn9 15 4 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 15 5 pandemic pandemic NN cord-333368-kjrk8nn9 15 6 has have VBZ cord-333368-kjrk8nn9 15 7 forced force VBN cord-333368-kjrk8nn9 15 8 reconsideration reconsideration NN cord-333368-kjrk8nn9 15 9 of of IN cord-333368-kjrk8nn9 15 10 the the DT cord-333368-kjrk8nn9 15 11 impact impact NN cord-333368-kjrk8nn9 15 12 of of IN cord-333368-kjrk8nn9 15 13 obesity obesity NN cord-333368-kjrk8nn9 15 14 and and CC cord-333368-kjrk8nn9 15 15 diabetes diabetes NN cord-333368-kjrk8nn9 15 16 on on IN cord-333368-kjrk8nn9 15 17 disease disease NN cord-333368-kjrk8nn9 15 18 outcomes outcome NNS cord-333368-kjrk8nn9 15 19 . . . cord-333368-kjrk8nn9 16 1 While while IN cord-333368-kjrk8nn9 16 2 obesity obesity NN cord-333368-kjrk8nn9 16 3 and and CC cord-333368-kjrk8nn9 16 4 diabetes diabetes NN cord-333368-kjrk8nn9 16 5 may may MD cord-333368-kjrk8nn9 16 6 complicate complicate VB cord-333368-kjrk8nn9 16 7 the the DT cord-333368-kjrk8nn9 16 8 delivery delivery NN cord-333368-kjrk8nn9 16 9 of of IN cord-333368-kjrk8nn9 16 10 supportive supportive JJ cord-333368-kjrk8nn9 16 11 care care NN cord-333368-kjrk8nn9 16 12 in in IN cord-333368-kjrk8nn9 16 13 critical critical JJ cord-333368-kjrk8nn9 16 14 illness illness NN cord-333368-kjrk8nn9 16 15 regardless regardless RB cord-333368-kjrk8nn9 16 16 of of IN cord-333368-kjrk8nn9 16 17 the the DT cord-333368-kjrk8nn9 16 18 underlying underlie VBG cord-333368-kjrk8nn9 16 19 disease disease NN cord-333368-kjrk8nn9 16 20 , , , cord-333368-kjrk8nn9 16 21 lessons lesson NNS cord-333368-kjrk8nn9 16 22 learned learn VBN cord-333368-kjrk8nn9 16 23 from from IN cord-333368-kjrk8nn9 16 24 the the DT cord-333368-kjrk8nn9 16 25 interaction interaction NN cord-333368-kjrk8nn9 16 26 of of IN cord-333368-kjrk8nn9 16 27 obesity obesity NN cord-333368-kjrk8nn9 16 28 with with IN cord-333368-kjrk8nn9 16 29 other other JJ cord-333368-kjrk8nn9 16 30 systemic systemic JJ cord-333368-kjrk8nn9 16 31 inflammatory inflammatory JJ cord-333368-kjrk8nn9 16 32 syndromes syndrome NNS cord-333368-kjrk8nn9 16 33 suggest suggest VBP cord-333368-kjrk8nn9 16 34 that that IN cord-333368-kjrk8nn9 16 35 obesity obesity NN cord-333368-kjrk8nn9 16 36 modifies modify VBZ cord-333368-kjrk8nn9 16 37 biologic biologic JJ cord-333368-kjrk8nn9 16 38 factors factor NNS cord-333368-kjrk8nn9 16 39 related relate VBN cord-333368-kjrk8nn9 16 40 to to IN cord-333368-kjrk8nn9 16 41 SARS SARS NNP cord-333368-kjrk8nn9 16 42 - - HYPH cord-333368-kjrk8nn9 16 43 CoV-2 CoV-2 NNP cord-333368-kjrk8nn9 16 44 infection infection NN cord-333368-kjrk8nn9 16 45 and and CC cord-333368-kjrk8nn9 16 46 the the DT cord-333368-kjrk8nn9 16 47 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 16 48 syndrome syndrome NN cord-333368-kjrk8nn9 16 49 . . . cord-333368-kjrk8nn9 17 1 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 17 2 was be VBD cord-333368-kjrk8nn9 17 3 first first RB cord-333368-kjrk8nn9 17 4 reported report VBN cord-333368-kjrk8nn9 17 5 in in IN cord-333368-kjrk8nn9 17 6 Wuhan Wuhan NNP cord-333368-kjrk8nn9 17 7 , , , cord-333368-kjrk8nn9 17 8 China China NNP cord-333368-kjrk8nn9 17 9 in in IN cord-333368-kjrk8nn9 17 10 December December NNP cord-333368-kjrk8nn9 17 11 2019 2019 CD cord-333368-kjrk8nn9 17 12 and and CC cord-333368-kjrk8nn9 17 13 first first RB cord-333368-kjrk8nn9 17 14 made make VBD cord-333368-kjrk8nn9 17 15 its -PRON- PRP$ cord-333368-kjrk8nn9 17 16 appearance appearance NN cord-333368-kjrk8nn9 17 17 in in IN cord-333368-kjrk8nn9 17 18 the the DT cord-333368-kjrk8nn9 17 19 United United NNP cord-333368-kjrk8nn9 17 20 States States NNP cord-333368-kjrk8nn9 17 21 in in IN cord-333368-kjrk8nn9 17 22 Washington Washington NNP cord-333368-kjrk8nn9 17 23 State State NNP cord-333368-kjrk8nn9 17 24 on on IN cord-333368-kjrk8nn9 17 25 January January NNP cord-333368-kjrk8nn9 17 26 31 31 CD cord-333368-kjrk8nn9 17 27 , , , cord-333368-kjrk8nn9 17 28 2020 2020 CD cord-333368-kjrk8nn9 17 29 . . . cord-333368-kjrk8nn9 18 1 Outbreaks outbreak NNS cord-333368-kjrk8nn9 18 2 quickly quickly RB cord-333368-kjrk8nn9 18 3 spread spread VBD cord-333368-kjrk8nn9 18 4 throughout throughout IN cord-333368-kjrk8nn9 18 5 Washington Washington NNP cord-333368-kjrk8nn9 18 6 and and CC cord-333368-kjrk8nn9 18 7 California California NNP cord-333368-kjrk8nn9 18 8 before before IN cord-333368-kjrk8nn9 18 9 spreading spread VBG cord-333368-kjrk8nn9 18 10 to to IN cord-333368-kjrk8nn9 18 11 the the DT cord-333368-kjrk8nn9 18 12 rest rest NN cord-333368-kjrk8nn9 18 13 of of IN cord-333368-kjrk8nn9 18 14 the the DT cord-333368-kjrk8nn9 18 15 US US NNP cord-333368-kjrk8nn9 18 16 . . . cord-333368-kjrk8nn9 19 1 Obesity obesity NN cord-333368-kjrk8nn9 19 2 was be VBD cord-333368-kjrk8nn9 19 3 not not RB cord-333368-kjrk8nn9 19 4 studied study VBN cord-333368-kjrk8nn9 19 5 in in IN cord-333368-kjrk8nn9 19 6 the the DT cord-333368-kjrk8nn9 19 7 early early JJ cord-333368-kjrk8nn9 19 8 SARS SARS NNP cord-333368-kjrk8nn9 19 9 - - HYPH cord-333368-kjrk8nn9 19 10 CoV-2 CoV-2 NNP cord-333368-kjrk8nn9 19 11 studies study NNS cord-333368-kjrk8nn9 19 12 coming come VBG cord-333368-kjrk8nn9 19 13 from from IN cord-333368-kjrk8nn9 19 14 Wuhan Wuhan NNP cord-333368-kjrk8nn9 19 15 , , , cord-333368-kjrk8nn9 19 16 China China NNP cord-333368-kjrk8nn9 19 17 , , , cord-333368-kjrk8nn9 19 18 likely likely JJ cord-333368-kjrk8nn9 19 19 because because IN cord-333368-kjrk8nn9 19 20 so so RB cord-333368-kjrk8nn9 19 21 little little JJ cord-333368-kjrk8nn9 19 22 of of IN cord-333368-kjrk8nn9 19 23 the the DT cord-333368-kjrk8nn9 19 24 population population NN cord-333368-kjrk8nn9 19 25 is be VBZ cord-333368-kjrk8nn9 19 26 obese obese JJ cord-333368-kjrk8nn9 19 27 . . . cord-333368-kjrk8nn9 20 1 However however RB cord-333368-kjrk8nn9 20 2 , , , cord-333368-kjrk8nn9 20 3 pre pre JJ cord-333368-kjrk8nn9 20 4 - - JJ cord-333368-kjrk8nn9 20 5 existing existing JJ cord-333368-kjrk8nn9 20 6 type type NN cord-333368-kjrk8nn9 20 7 2 2 CD cord-333368-kjrk8nn9 20 8 diabetes diabetes NN cord-333368-kjrk8nn9 20 9 was be VBD cord-333368-kjrk8nn9 20 10 demonstrated demonstrate VBN cord-333368-kjrk8nn9 20 11 to to TO cord-333368-kjrk8nn9 20 12 be be VB cord-333368-kjrk8nn9 20 13 a a DT cord-333368-kjrk8nn9 20 14 risk risk NN cord-333368-kjrk8nn9 20 15 factor factor NN cord-333368-kjrk8nn9 20 16 for for IN cord-333368-kjrk8nn9 20 17 illness illness NN cord-333368-kjrk8nn9 20 18 severity severity NN cord-333368-kjrk8nn9 20 19 5 5 CD cord-333368-kjrk8nn9 20 20 . . . cord-333368-kjrk8nn9 21 1 In in IN cord-333368-kjrk8nn9 21 2 the the DT cord-333368-kjrk8nn9 21 3 US US NNP cord-333368-kjrk8nn9 21 4 , , , cord-333368-kjrk8nn9 21 5 obesity obesity NN cord-333368-kjrk8nn9 21 6 , , , cord-333368-kjrk8nn9 21 7 hypertension hypertension NN cord-333368-kjrk8nn9 21 8 , , , cord-333368-kjrk8nn9 21 9 and and CC cord-333368-kjrk8nn9 21 10 diabetes diabetes NN cord-333368-kjrk8nn9 21 11 are be VBP cord-333368-kjrk8nn9 21 12 commonly commonly RB cord-333368-kjrk8nn9 21 13 reported report VBN cord-333368-kjrk8nn9 21 14 among among IN cord-333368-kjrk8nn9 21 15 the the DT cord-333368-kjrk8nn9 21 16 most most RBS cord-333368-kjrk8nn9 21 17 common common JJ cord-333368-kjrk8nn9 21 18 comorbidities comorbiditie NNS cord-333368-kjrk8nn9 21 19 for for IN cord-333368-kjrk8nn9 21 20 patients patient NNS cord-333368-kjrk8nn9 21 21 hospitalized hospitalize VBN cord-333368-kjrk8nn9 21 22 with with IN cord-333368-kjrk8nn9 21 23 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 21 24 across across IN cord-333368-kjrk8nn9 21 25 several several JJ cord-333368-kjrk8nn9 21 26 metropolitan metropolitan JJ cord-333368-kjrk8nn9 21 27 disease disease NN cord-333368-kjrk8nn9 21 28 outbreaks outbreak NNS cord-333368-kjrk8nn9 21 29 2,6 2,6 CD cord-333368-kjrk8nn9 21 30 - - SYM cord-333368-kjrk8nn9 21 31 8 8 CD cord-333368-kjrk8nn9 21 32 . . . cord-333368-kjrk8nn9 22 1 When when WRB cord-333368-kjrk8nn9 22 2 considering consider VBG cord-333368-kjrk8nn9 22 3 the the DT cord-333368-kjrk8nn9 22 4 obesity obesity NN cord-333368-kjrk8nn9 22 5 epidemic epidemic NN cord-333368-kjrk8nn9 22 6 in in IN cord-333368-kjrk8nn9 22 7 the the DT cord-333368-kjrk8nn9 22 8 US US NNP cord-333368-kjrk8nn9 22 9 , , , cord-333368-kjrk8nn9 22 10 this this DT cord-333368-kjrk8nn9 22 11 is be VBZ cord-333368-kjrk8nn9 22 12 not not RB cord-333368-kjrk8nn9 22 13 surprising surprising JJ cord-333368-kjrk8nn9 22 14 , , , cord-333368-kjrk8nn9 22 15 as as IN cord-333368-kjrk8nn9 22 16 approximately approximately RB cord-333368-kjrk8nn9 22 17 35 35 CD cord-333368-kjrk8nn9 22 18 % % NN cord-333368-kjrk8nn9 22 19 of of IN cord-333368-kjrk8nn9 22 20 men man NNS cord-333368-kjrk8nn9 22 21 and and CC cord-333368-kjrk8nn9 22 22 40 40 CD cord-333368-kjrk8nn9 22 23 % % NN cord-333368-kjrk8nn9 22 24 of of IN cord-333368-kjrk8nn9 22 25 women woman NNS cord-333368-kjrk8nn9 22 26 in in IN cord-333368-kjrk8nn9 22 27 the the DT cord-333368-kjrk8nn9 22 28 United United NNP cord-333368-kjrk8nn9 22 29 States States NNP cord-333368-kjrk8nn9 22 30 are be VBP cord-333368-kjrk8nn9 22 31 obese obese JJ cord-333368-kjrk8nn9 22 32 by by IN cord-333368-kjrk8nn9 22 33 body body NN cord-333368-kjrk8nn9 22 34 mass mass NN cord-333368-kjrk8nn9 22 35 index index NN cord-333368-kjrk8nn9 22 36 ( ( -LRB- cord-333368-kjrk8nn9 22 37 BMI BMI NNP cord-333368-kjrk8nn9 22 38 > > XX cord-333368-kjrk8nn9 22 39 30 30 CD cord-333368-kjrk8nn9 22 40 kg kg NNP cord-333368-kjrk8nn9 22 41 / / SYM cord-333368-kjrk8nn9 22 42 m2 m2 NNP cord-333368-kjrk8nn9 22 43 ) ) -RRB- cord-333368-kjrk8nn9 22 44 9 9 CD cord-333368-kjrk8nn9 22 45 , , , cord-333368-kjrk8nn9 22 46 10 10 CD cord-333368-kjrk8nn9 22 47 . . . cord-333368-kjrk8nn9 23 1 However however RB cord-333368-kjrk8nn9 23 2 , , , cord-333368-kjrk8nn9 23 3 obesity obesity NN cord-333368-kjrk8nn9 23 4 is be VBZ cord-333368-kjrk8nn9 23 5 independently independently RB cord-333368-kjrk8nn9 23 6 associated associate VBN cord-333368-kjrk8nn9 23 7 with with IN cord-333368-kjrk8nn9 23 8 odds odd NNS cord-333368-kjrk8nn9 23 9 of of IN cord-333368-kjrk8nn9 23 10 hospital hospital NN cord-333368-kjrk8nn9 23 11 or or CC cord-333368-kjrk8nn9 23 12 intensive intensive JJ cord-333368-kjrk8nn9 23 13 care care NN cord-333368-kjrk8nn9 23 14 admission admission NN cord-333368-kjrk8nn9 23 15 among among IN cord-333368-kjrk8nn9 23 16 patients patient NNS cord-333368-kjrk8nn9 23 17 presenting present VBG cord-333368-kjrk8nn9 23 18 for for IN cord-333368-kjrk8nn9 23 19 medical medical JJ cord-333368-kjrk8nn9 23 20 care care NN cord-333368-kjrk8nn9 23 21 1 1 CD cord-333368-kjrk8nn9 23 22 , , , cord-333368-kjrk8nn9 23 23 2 2 CD cord-333368-kjrk8nn9 23 24 . . . cord-333368-kjrk8nn9 24 1 Several several JJ cord-333368-kjrk8nn9 24 2 studies study NNS cord-333368-kjrk8nn9 24 3 suggest suggest VBP cord-333368-kjrk8nn9 24 4 that that IN cord-333368-kjrk8nn9 24 5 A a NN cord-333368-kjrk8nn9 24 6 c c NN cord-333368-kjrk8nn9 24 7 c c NN cord-333368-kjrk8nn9 24 8 e e NN cord-333368-kjrk8nn9 24 9 p p NN cord-333368-kjrk8nn9 24 10 t t NN cord-333368-kjrk8nn9 24 11 e e NN cord-333368-kjrk8nn9 24 12 d d NNP cord-333368-kjrk8nn9 24 13 M M NNP cord-333368-kjrk8nn9 24 14 a a NNP cord-333368-kjrk8nn9 24 15 n n NN cord-333368-kjrk8nn9 24 16 u u NNP cord-333368-kjrk8nn9 24 17 s s NNP cord-333368-kjrk8nn9 24 18 c c NN cord-333368-kjrk8nn9 24 19 r r NN cord-333368-kjrk8nn9 24 20 i i NN cord-333368-kjrk8nn9 24 21 p p NN cord-333368-kjrk8nn9 24 22 t t NN cord-333368-kjrk8nn9 24 23 4 4 CD cord-333368-kjrk8nn9 24 24 obesity obesity NN cord-333368-kjrk8nn9 24 25 is be VBZ cord-333368-kjrk8nn9 24 26 an an DT cord-333368-kjrk8nn9 24 27 independent independent JJ cord-333368-kjrk8nn9 24 28 predictor predictor NN cord-333368-kjrk8nn9 24 29 of of IN cord-333368-kjrk8nn9 24 30 hypoxic hypoxic JJ cord-333368-kjrk8nn9 24 31 respiratory respiratory JJ cord-333368-kjrk8nn9 24 32 failure failure NN cord-333368-kjrk8nn9 24 33 11 11 CD cord-333368-kjrk8nn9 24 34 , , , cord-333368-kjrk8nn9 24 35 12 12 CD cord-333368-kjrk8nn9 24 36 and and CC cord-333368-kjrk8nn9 24 37 death death NN cord-333368-kjrk8nn9 24 38 13,14 13,14 CD cord-333368-kjrk8nn9 24 39 among among IN cord-333368-kjrk8nn9 24 40 hospitalized hospitalize VBN cord-333368-kjrk8nn9 24 41 patients patient NNS cord-333368-kjrk8nn9 24 42 , , , cord-333368-kjrk8nn9 24 43 even even RB cord-333368-kjrk8nn9 24 44 among among IN cord-333368-kjrk8nn9 24 45 young young JJ cord-333368-kjrk8nn9 24 46 patients patient NNS cord-333368-kjrk8nn9 24 47 with with IN cord-333368-kjrk8nn9 24 48 fewer few JJR cord-333368-kjrk8nn9 24 49 comorbidities comorbiditie NNS cord-333368-kjrk8nn9 24 50 15 15 CD cord-333368-kjrk8nn9 24 51 , , , cord-333368-kjrk8nn9 24 52 16 16 CD cord-333368-kjrk8nn9 24 53 . . . cord-333368-kjrk8nn9 25 1 Decisions decision NNS cord-333368-kjrk8nn9 25 2 about about IN cord-333368-kjrk8nn9 25 3 hospital hospital NN cord-333368-kjrk8nn9 25 4 admission admission NN cord-333368-kjrk8nn9 25 5 , , , cord-333368-kjrk8nn9 25 6 and and CC cord-333368-kjrk8nn9 25 7 thus thus RB cord-333368-kjrk8nn9 25 8 the the DT cord-333368-kjrk8nn9 25 9 characteristics characteristic NNS cord-333368-kjrk8nn9 25 10 of of IN cord-333368-kjrk8nn9 25 11 hospitalized hospitalize VBN cord-333368-kjrk8nn9 25 12 patients patient NNS cord-333368-kjrk8nn9 25 13 , , , cord-333368-kjrk8nn9 25 14 may may MD cord-333368-kjrk8nn9 25 15 be be VB cord-333368-kjrk8nn9 25 16 confounded confound VBN cord-333368-kjrk8nn9 25 17 by by IN cord-333368-kjrk8nn9 25 18 the the DT cord-333368-kjrk8nn9 25 19 expectation expectation NN cord-333368-kjrk8nn9 25 20 that that IN cord-333368-kjrk8nn9 25 21 obese obese JJ cord-333368-kjrk8nn9 25 22 patients patient NNS cord-333368-kjrk8nn9 25 23 require require VBP cord-333368-kjrk8nn9 25 24 closer close JJR cord-333368-kjrk8nn9 25 25 monitoring monitoring NN cord-333368-kjrk8nn9 25 26 . . . cord-333368-kjrk8nn9 26 1 Population population NN cord-333368-kjrk8nn9 26 2 - - HYPH cord-333368-kjrk8nn9 26 3 based base VBN cord-333368-kjrk8nn9 26 4 estimates estimate NNS cord-333368-kjrk8nn9 26 5 of of IN cord-333368-kjrk8nn9 26 6 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 26 7 mortality mortality NN cord-333368-kjrk8nn9 26 8 , , , cord-333368-kjrk8nn9 26 9 however however RB cord-333368-kjrk8nn9 26 10 , , , cord-333368-kjrk8nn9 26 11 also also RB cord-333368-kjrk8nn9 26 12 show show VBP cord-333368-kjrk8nn9 26 13 a a DT cord-333368-kjrk8nn9 26 14 2.6-fold 2.6-fold CD cord-333368-kjrk8nn9 26 15 increase increase NN cord-333368-kjrk8nn9 26 16 in in IN cord-333368-kjrk8nn9 26 17 risk risk NN cord-333368-kjrk8nn9 26 18 for for IN cord-333368-kjrk8nn9 26 19 patients patient NNS cord-333368-kjrk8nn9 26 20 with with IN cord-333368-kjrk8nn9 26 21 BMI BMI NNP cord-333368-kjrk8nn9 26 22 > > NNP cord-333368-kjrk8nn9 26 23 40 40 CD cord-333368-kjrk8nn9 26 24 17 17 CD cord-333368-kjrk8nn9 26 25 . . . cord-333368-kjrk8nn9 27 1 Prior Prior NNP cord-333368-kjrk8nn9 27 2 meta meta NNP cord-333368-kjrk8nn9 27 3 - - HYPH cord-333368-kjrk8nn9 27 4 analyses analysis NNS cord-333368-kjrk8nn9 27 5 of of IN cord-333368-kjrk8nn9 27 6 both both DT cord-333368-kjrk8nn9 27 7 ARDS ARDS NNP cord-333368-kjrk8nn9 27 8 and and CC cord-333368-kjrk8nn9 27 9 sepsis sepsis NN cord-333368-kjrk8nn9 27 10 have have VBP cord-333368-kjrk8nn9 27 11 found find VBN cord-333368-kjrk8nn9 27 12 either either CC cord-333368-kjrk8nn9 27 13 no no DT cord-333368-kjrk8nn9 27 14 harm harm NN cord-333368-kjrk8nn9 27 15 or or CC cord-333368-kjrk8nn9 27 16 reduction reduction NN cord-333368-kjrk8nn9 27 17 in in IN cord-333368-kjrk8nn9 27 18 mortality mortality NN cord-333368-kjrk8nn9 27 19 among among IN cord-333368-kjrk8nn9 27 20 obese obese JJ cord-333368-kjrk8nn9 27 21 adults adult NNS cord-333368-kjrk8nn9 27 22 18 18 CD cord-333368-kjrk8nn9 27 23 , , , cord-333368-kjrk8nn9 27 24 19 19 CD cord-333368-kjrk8nn9 27 25 . . . cord-333368-kjrk8nn9 28 1 However however RB cord-333368-kjrk8nn9 28 2 , , , cord-333368-kjrk8nn9 28 3 severity severity NN cord-333368-kjrk8nn9 28 4 of of IN cord-333368-kjrk8nn9 28 5 illness illness NN cord-333368-kjrk8nn9 28 6 and and CC cord-333368-kjrk8nn9 28 7 organ organ NN cord-333368-kjrk8nn9 28 8 damage damage NN cord-333368-kjrk8nn9 28 9 has have VBZ cord-333368-kjrk8nn9 28 10 been be VBN cord-333368-kjrk8nn9 28 11 demonstrated demonstrate VBN cord-333368-kjrk8nn9 28 12 to to TO cord-333368-kjrk8nn9 28 13 increase increase VB cord-333368-kjrk8nn9 28 14 based base VBN cord-333368-kjrk8nn9 28 15 on on IN cord-333368-kjrk8nn9 28 16 obesity obesity NN cord-333368-kjrk8nn9 28 17 in in IN cord-333368-kjrk8nn9 28 18 pediatric pediatric JJ cord-333368-kjrk8nn9 28 19 patients patient NNS cord-333368-kjrk8nn9 28 20 [ [ -LRB- cord-333368-kjrk8nn9 28 21 20 20 CD cord-333368-kjrk8nn9 28 22 ] ] -RRB- cord-333368-kjrk8nn9 29 1 [ [ -LRB- cord-333368-kjrk8nn9 29 2 21 21 CD cord-333368-kjrk8nn9 29 3 ] ] -RRB- cord-333368-kjrk8nn9 29 4 [ [ -LRB- cord-333368-kjrk8nn9 29 5 22 22 CD cord-333368-kjrk8nn9 29 6 ] ] -RRB- cord-333368-kjrk8nn9 29 7 [ [ -LRB- cord-333368-kjrk8nn9 29 8 23 23 CD cord-333368-kjrk8nn9 29 9 ] ] -RRB- cord-333368-kjrk8nn9 29 10 . . . cord-333368-kjrk8nn9 30 1 While while IN cord-333368-kjrk8nn9 30 2 changes change NNS cord-333368-kjrk8nn9 30 3 in in IN cord-333368-kjrk8nn9 30 4 critical critical JJ cord-333368-kjrk8nn9 30 5 care care NN cord-333368-kjrk8nn9 30 6 practice practice NN cord-333368-kjrk8nn9 30 7 during during IN cord-333368-kjrk8nn9 30 8 a a DT cord-333368-kjrk8nn9 30 9 pandemic pandemic NN cord-333368-kjrk8nn9 30 10 could could MD cord-333368-kjrk8nn9 30 11 explain explain VB cord-333368-kjrk8nn9 30 12 differences difference NNS cord-333368-kjrk8nn9 30 13 in in IN cord-333368-kjrk8nn9 30 14 mortality mortality NN cord-333368-kjrk8nn9 30 15 or or CC cord-333368-kjrk8nn9 30 16 ICU ICU NNP cord-333368-kjrk8nn9 30 17 admission admission NN cord-333368-kjrk8nn9 30 18 , , , cord-333368-kjrk8nn9 30 19 the the DT cord-333368-kjrk8nn9 30 20 association association NN cord-333368-kjrk8nn9 30 21 of of IN cord-333368-kjrk8nn9 30 22 obesity obesity NN cord-333368-kjrk8nn9 30 23 with with IN cord-333368-kjrk8nn9 30 24 physiologically physiologically RB cord-333368-kjrk8nn9 30 25 defined define VBN cord-333368-kjrk8nn9 30 26 hypoxic hypoxic JJ cord-333368-kjrk8nn9 30 27 respiratory respiratory JJ cord-333368-kjrk8nn9 30 28 failure failure NN cord-333368-kjrk8nn9 30 29 suggests suggest VBZ cord-333368-kjrk8nn9 30 30 a a DT cord-333368-kjrk8nn9 30 31 biologic biologic JJ cord-333368-kjrk8nn9 30 32 interaction interaction NN cord-333368-kjrk8nn9 30 33 of of IN cord-333368-kjrk8nn9 30 34 obesity obesity NN cord-333368-kjrk8nn9 30 35 with with IN cord-333368-kjrk8nn9 30 36 SARS SARS NNP cord-333368-kjrk8nn9 30 37 - - HYPH cord-333368-kjrk8nn9 30 38 CoV-2 CoV-2 NNP cord-333368-kjrk8nn9 30 39 infection infection NN cord-333368-kjrk8nn9 30 40 . . . cord-333368-kjrk8nn9 31 1 Obesity obesity NN cord-333368-kjrk8nn9 31 2 as as IN cord-333368-kjrk8nn9 31 3 a a DT cord-333368-kjrk8nn9 31 4 risk risk NN cord-333368-kjrk8nn9 31 5 factor factor NN cord-333368-kjrk8nn9 31 6 for for IN cord-333368-kjrk8nn9 31 7 severe severe JJ cord-333368-kjrk8nn9 31 8 infectious infectious JJ cord-333368-kjrk8nn9 31 9 disease disease NN cord-333368-kjrk8nn9 31 10 is be VBZ cord-333368-kjrk8nn9 31 11 not not RB cord-333368-kjrk8nn9 31 12 a a DT cord-333368-kjrk8nn9 31 13 new new JJ cord-333368-kjrk8nn9 31 14 concept concept NN cord-333368-kjrk8nn9 31 15 and and CC cord-333368-kjrk8nn9 31 16 is be VBZ cord-333368-kjrk8nn9 31 17 not not RB cord-333368-kjrk8nn9 31 18 limited limit VBN cord-333368-kjrk8nn9 31 19 to to IN cord-333368-kjrk8nn9 31 20 coronavirus coronavirus NN cord-333368-kjrk8nn9 31 21 infections infection NNS cord-333368-kjrk8nn9 31 22 . . . cord-333368-kjrk8nn9 32 1 During during IN cord-333368-kjrk8nn9 32 2 the the DT cord-333368-kjrk8nn9 32 3 2009 2009 CD cord-333368-kjrk8nn9 32 4 influenza influenza NN cord-333368-kjrk8nn9 32 5 A A NNP cord-333368-kjrk8nn9 32 6 / / SYM cord-333368-kjrk8nn9 32 7 H1N1 H1N1 NNP cord-333368-kjrk8nn9 32 8 pandemic pandemic NN cord-333368-kjrk8nn9 32 9 , , , cord-333368-kjrk8nn9 32 10 it -PRON- PRP cord-333368-kjrk8nn9 32 11 was be VBD cord-333368-kjrk8nn9 32 12 noted note VBN cord-333368-kjrk8nn9 32 13 that that IN cord-333368-kjrk8nn9 32 14 obese obese JJ cord-333368-kjrk8nn9 32 15 patients patient NNS cord-333368-kjrk8nn9 32 16 were be VBD cord-333368-kjrk8nn9 32 17 more more RBR cord-333368-kjrk8nn9 32 18 likely likely JJ cord-333368-kjrk8nn9 32 19 to to TO cord-333368-kjrk8nn9 32 20 experience experience VB cord-333368-kjrk8nn9 32 21 more more RBR cord-333368-kjrk8nn9 32 22 severe severe JJ cord-333368-kjrk8nn9 32 23 disease disease NN cord-333368-kjrk8nn9 32 24 requiring require VBG cord-333368-kjrk8nn9 32 25 hospitalization hospitalization NN cord-333368-kjrk8nn9 32 26 than than IN cord-333368-kjrk8nn9 32 27 normal normal JJ cord-333368-kjrk8nn9 32 28 weight weight NN cord-333368-kjrk8nn9 32 29 patients patient NNS cord-333368-kjrk8nn9 32 30 24 24 CD cord-333368-kjrk8nn9 32 31 . . . cord-333368-kjrk8nn9 33 1 Additionally additionally RB cord-333368-kjrk8nn9 33 2 , , , cord-333368-kjrk8nn9 33 3 even even RB cord-333368-kjrk8nn9 33 4 when when WRB cord-333368-kjrk8nn9 33 5 both both DT cord-333368-kjrk8nn9 33 6 groups group NNS cord-333368-kjrk8nn9 33 7 were be VBD cord-333368-kjrk8nn9 33 8 vaccinated vaccinate VBN cord-333368-kjrk8nn9 33 9 , , , cord-333368-kjrk8nn9 33 10 obese obese JJ cord-333368-kjrk8nn9 33 11 individuals individual NNS cord-333368-kjrk8nn9 33 12 were be VBD cord-333368-kjrk8nn9 33 13 more more RBR cord-333368-kjrk8nn9 33 14 likely likely JJ cord-333368-kjrk8nn9 33 15 to to TO cord-333368-kjrk8nn9 33 16 become become VB cord-333368-kjrk8nn9 33 17 infected infect VBN cord-333368-kjrk8nn9 33 18 with with IN cord-333368-kjrk8nn9 33 19 the the DT cord-333368-kjrk8nn9 33 20 influenza influenza NN cord-333368-kjrk8nn9 33 21 virus virus NN cord-333368-kjrk8nn9 33 22 25 25 CD cord-333368-kjrk8nn9 33 23 . . . cord-333368-kjrk8nn9 34 1 Along along IN cord-333368-kjrk8nn9 34 2 with with IN cord-333368-kjrk8nn9 34 3 viral viral JJ cord-333368-kjrk8nn9 34 4 infections infection NNS cord-333368-kjrk8nn9 34 5 , , , cord-333368-kjrk8nn9 34 6 obesity obesity NN cord-333368-kjrk8nn9 34 7 alters alter VBZ cord-333368-kjrk8nn9 34 8 the the DT cord-333368-kjrk8nn9 34 9 course course NN cord-333368-kjrk8nn9 34 10 of of IN cord-333368-kjrk8nn9 34 11 bacterial bacterial JJ cord-333368-kjrk8nn9 34 12 infections infection NNS cord-333368-kjrk8nn9 34 13 26 26 CD cord-333368-kjrk8nn9 34 14 . . . cord-333368-kjrk8nn9 35 1 All all DT cord-333368-kjrk8nn9 35 2 of of IN cord-333368-kjrk8nn9 35 3 this this DT cord-333368-kjrk8nn9 35 4 clinical clinical JJ cord-333368-kjrk8nn9 35 5 evidence evidence NN cord-333368-kjrk8nn9 35 6 emphasizes emphasize VBZ cord-333368-kjrk8nn9 35 7 the the DT cord-333368-kjrk8nn9 35 8 importance importance NN cord-333368-kjrk8nn9 35 9 of of IN cord-333368-kjrk8nn9 35 10 further further JJ cord-333368-kjrk8nn9 35 11 understanding understand VBG cord-333368-kjrk8nn9 35 12 the the DT cord-333368-kjrk8nn9 35 13 mechanisms mechanism NNS cord-333368-kjrk8nn9 35 14 by by IN cord-333368-kjrk8nn9 35 15 which which WDT cord-333368-kjrk8nn9 35 16 obesity obesity NN cord-333368-kjrk8nn9 35 17 influences influence VBZ cord-333368-kjrk8nn9 35 18 immune immune JJ cord-333368-kjrk8nn9 35 19 responses response NNS cord-333368-kjrk8nn9 35 20 . . . cord-333368-kjrk8nn9 36 1 The the DT cord-333368-kjrk8nn9 36 2 current current JJ cord-333368-kjrk8nn9 36 3 SARS SARS NNP cord-333368-kjrk8nn9 36 4 - - HYPH cord-333368-kjrk8nn9 36 5 CoV-2 CoV-2 NNP cord-333368-kjrk8nn9 36 6 pandemic pandemic NN cord-333368-kjrk8nn9 36 7 has have VBZ cord-333368-kjrk8nn9 36 8 highlighted highlight VBN cord-333368-kjrk8nn9 36 9 the the DT cord-333368-kjrk8nn9 36 10 increased increase VBN cord-333368-kjrk8nn9 36 11 need need NN cord-333368-kjrk8nn9 36 12 for for IN cord-333368-kjrk8nn9 36 13 research research NN cord-333368-kjrk8nn9 36 14 to to TO cord-333368-kjrk8nn9 36 15 understand understand VB cord-333368-kjrk8nn9 36 16 the the DT cord-333368-kjrk8nn9 36 17 mechanisms mechanism NNS cord-333368-kjrk8nn9 36 18 behind behind IN cord-333368-kjrk8nn9 36 19 severity severity NN cord-333368-kjrk8nn9 36 20 of of IN cord-333368-kjrk8nn9 36 21 pandemic pandemic JJ cord-333368-kjrk8nn9 36 22 infection infection NN cord-333368-kjrk8nn9 36 23 in in IN cord-333368-kjrk8nn9 36 24 different different JJ cord-333368-kjrk8nn9 36 25 risk risk NN cord-333368-kjrk8nn9 36 26 groups group NNS cord-333368-kjrk8nn9 36 27 . . . cord-333368-kjrk8nn9 37 1 A a DT cord-333368-kjrk8nn9 37 2 c c NN cord-333368-kjrk8nn9 37 3 c c NN cord-333368-kjrk8nn9 37 4 e e NN cord-333368-kjrk8nn9 37 5 p p NN cord-333368-kjrk8nn9 37 6 t t NN cord-333368-kjrk8nn9 37 7 e e NN cord-333368-kjrk8nn9 37 8 d d NNP cord-333368-kjrk8nn9 37 9 M M NNP cord-333368-kjrk8nn9 37 10 a a NNP cord-333368-kjrk8nn9 37 11 n n NN cord-333368-kjrk8nn9 37 12 u u NNP cord-333368-kjrk8nn9 37 13 s s NNP cord-333368-kjrk8nn9 37 14 c c NN cord-333368-kjrk8nn9 37 15 r r NN cord-333368-kjrk8nn9 37 16 i i NN cord-333368-kjrk8nn9 37 17 p p NN cord-333368-kjrk8nn9 37 18 t t NN cord-333368-kjrk8nn9 37 19 5 5 CD cord-333368-kjrk8nn9 37 20 With with IN cord-333368-kjrk8nn9 37 21 the the DT cord-333368-kjrk8nn9 37 22 prevalence prevalence NN cord-333368-kjrk8nn9 37 23 of of IN cord-333368-kjrk8nn9 37 24 obesity obesity NN cord-333368-kjrk8nn9 37 25 rising rise VBG cord-333368-kjrk8nn9 37 26 without without IN cord-333368-kjrk8nn9 37 27 an an DT cord-333368-kjrk8nn9 37 28 end end NN cord-333368-kjrk8nn9 37 29 in in IN cord-333368-kjrk8nn9 37 30 sight sight NN cord-333368-kjrk8nn9 37 31 , , , cord-333368-kjrk8nn9 37 32 it -PRON- PRP cord-333368-kjrk8nn9 37 33 is be VBZ cord-333368-kjrk8nn9 37 34 important important JJ cord-333368-kjrk8nn9 37 35 to to TO cord-333368-kjrk8nn9 37 36 understand understand VB cord-333368-kjrk8nn9 37 37 the the DT cord-333368-kjrk8nn9 37 38 endocrine endocrine NN cord-333368-kjrk8nn9 37 39 , , , cord-333368-kjrk8nn9 37 40 metabolic metabolic JJ cord-333368-kjrk8nn9 37 41 , , , cord-333368-kjrk8nn9 37 42 and and CC cord-333368-kjrk8nn9 37 43 inflammatory inflammatory JJ cord-333368-kjrk8nn9 37 44 shifts shift NNS cord-333368-kjrk8nn9 37 45 that that WDT cord-333368-kjrk8nn9 37 46 occur occur VBP cord-333368-kjrk8nn9 37 47 in in IN cord-333368-kjrk8nn9 37 48 obesity obesity NN cord-333368-kjrk8nn9 37 49 may may MD cord-333368-kjrk8nn9 37 50 drive drive VB cord-333368-kjrk8nn9 37 51 increased increase VBN cord-333368-kjrk8nn9 37 52 pathogendriven pathogendriven NNP cord-333368-kjrk8nn9 37 53 morbidity morbidity NN cord-333368-kjrk8nn9 37 54 and and CC cord-333368-kjrk8nn9 37 55 mortality mortality NN cord-333368-kjrk8nn9 37 56 . . . cord-333368-kjrk8nn9 38 1 A a DT cord-333368-kjrk8nn9 38 2 c c NN cord-333368-kjrk8nn9 38 3 c c NN cord-333368-kjrk8nn9 38 4 e e NN cord-333368-kjrk8nn9 38 5 p p NN cord-333368-kjrk8nn9 38 6 t t NN cord-333368-kjrk8nn9 38 7 e e NN cord-333368-kjrk8nn9 38 8 d d NNP cord-333368-kjrk8nn9 38 9 M M NNP cord-333368-kjrk8nn9 38 10 a a NNP cord-333368-kjrk8nn9 38 11 n n NN cord-333368-kjrk8nn9 38 12 u u NNP cord-333368-kjrk8nn9 38 13 s s NN cord-333368-kjrk8nn9 38 14 c c NN cord-333368-kjrk8nn9 38 15 r r NN cord-333368-kjrk8nn9 39 1 i i PRP cord-333368-kjrk8nn9 40 1 p p NN cord-333368-kjrk8nn9 40 2 t t NN cord-333368-kjrk8nn9 40 3 6 6 CD cord-333368-kjrk8nn9 40 4 Pro pro JJ cord-333368-kjrk8nn9 40 5 - - JJ cord-333368-kjrk8nn9 40 6 inflammatory inflammatory JJ cord-333368-kjrk8nn9 40 7 circulating circulate VBG cord-333368-kjrk8nn9 40 8 monocyte monocyte NNP cord-333368-kjrk8nn9 40 9 and and CC cord-333368-kjrk8nn9 40 10 macrophage macrophage NN cord-333368-kjrk8nn9 40 11 populations population NNS cord-333368-kjrk8nn9 40 12 are be VBP cord-333368-kjrk8nn9 40 13 associated associate VBN cord-333368-kjrk8nn9 40 14 with with IN cord-333368-kjrk8nn9 40 15 a a DT cord-333368-kjrk8nn9 40 16 number number NN cord-333368-kjrk8nn9 40 17 of of IN cord-333368-kjrk8nn9 40 18 chronic chronic JJ cord-333368-kjrk8nn9 40 19 diseases disease NNS cord-333368-kjrk8nn9 40 20 , , , cord-333368-kjrk8nn9 40 21 including include VBG cord-333368-kjrk8nn9 40 22 obesity obesity NN cord-333368-kjrk8nn9 40 23 32 32 CD cord-333368-kjrk8nn9 40 24 . . . cord-333368-kjrk8nn9 41 1 A a DT cord-333368-kjrk8nn9 41 2 striking striking JJ cord-333368-kjrk8nn9 41 3 feature feature NN cord-333368-kjrk8nn9 41 4 of of IN cord-333368-kjrk8nn9 41 5 obesity obesity NN cord-333368-kjrk8nn9 41 6 in in IN cord-333368-kjrk8nn9 41 7 both both CC cord-333368-kjrk8nn9 41 8 clinical clinical JJ cord-333368-kjrk8nn9 41 9 and and CC cord-333368-kjrk8nn9 41 10 animal animal NN cord-333368-kjrk8nn9 41 11 studies study NNS cord-333368-kjrk8nn9 41 12 is be VBZ cord-333368-kjrk8nn9 41 13 the the DT cord-333368-kjrk8nn9 41 14 chronic chronic JJ cord-333368-kjrk8nn9 41 15 low low JJ cord-333368-kjrk8nn9 41 16 - - HYPH cord-333368-kjrk8nn9 41 17 grade grade NN cord-333368-kjrk8nn9 41 18 inflammation inflammation NN cord-333368-kjrk8nn9 41 19 tied tie VBN cord-333368-kjrk8nn9 41 20 with with IN cord-333368-kjrk8nn9 41 21 metabolic metabolic JJ cord-333368-kjrk8nn9 41 22 diseases disease NNS cord-333368-kjrk8nn9 41 23 , , , cord-333368-kjrk8nn9 41 24 meta meta NN cord-333368-kjrk8nn9 41 25 - - HYPH cord-333368-kjrk8nn9 41 26 inflammation inflammation NN cord-333368-kjrk8nn9 41 27 33 33 CD cord-333368-kjrk8nn9 41 28 . . . cord-333368-kjrk8nn9 42 1 Increased increase VBN cord-333368-kjrk8nn9 42 2 BMI BMI NNP cord-333368-kjrk8nn9 42 3 correlates correlate VBZ cord-333368-kjrk8nn9 42 4 with with IN cord-333368-kjrk8nn9 42 5 an an DT cord-333368-kjrk8nn9 42 6 increase increase NN cord-333368-kjrk8nn9 42 7 of of IN cord-333368-kjrk8nn9 42 8 several several JJ cord-333368-kjrk8nn9 42 9 cytokines cytokine NNS cord-333368-kjrk8nn9 42 10 including include VBG cord-333368-kjrk8nn9 42 11 IL-6 IL-6 NNP cord-333368-kjrk8nn9 42 12 , , , cord-333368-kjrk8nn9 42 13 IL-8 IL-8 NNP cord-333368-kjrk8nn9 42 14 , , , cord-333368-kjrk8nn9 42 15 IL-1 IL-1 NNP cord-333368-kjrk8nn9 42 16 , , , cord-333368-kjrk8nn9 42 17 and and CC cord-333368-kjrk8nn9 42 18 TNF- TNF- NNP cord-333368-kjrk8nn9 42 19 and and CC cord-333368-kjrk8nn9 42 20 obesity obesity NN cord-333368-kjrk8nn9 42 21 also also RB cord-333368-kjrk8nn9 42 22 correlates correlate VBZ cord-333368-kjrk8nn9 42 23 with with IN cord-333368-kjrk8nn9 42 24 an an DT cord-333368-kjrk8nn9 42 25 increase increase NN cord-333368-kjrk8nn9 42 26 in in IN cord-333368-kjrk8nn9 42 27 chemokines chemokine NNS cord-333368-kjrk8nn9 42 28 such such JJ cord-333368-kjrk8nn9 42 29 as as IN cord-333368-kjrk8nn9 42 30 CCL14 CCL14 NNP cord-333368-kjrk8nn9 42 31 34 34 CD cord-333368-kjrk8nn9 42 32 , , , cord-333368-kjrk8nn9 42 33 35 35 CD cord-333368-kjrk8nn9 42 34 and and CC cord-333368-kjrk8nn9 42 35 MCP-1 MCP-1 NNP cord-333368-kjrk8nn9 42 36 36 36 CD cord-333368-kjrk8nn9 42 37 furthering further VBG cord-333368-kjrk8nn9 42 38 the the DT cord-333368-kjrk8nn9 42 39 overall overall JJ cord-333368-kjrk8nn9 42 40 inflammatory inflammatory JJ cord-333368-kjrk8nn9 42 41 tone tone NN cord-333368-kjrk8nn9 42 42 . . . cord-333368-kjrk8nn9 43 1 Hyperglycemia hyperglycemia NN cord-333368-kjrk8nn9 43 2 alone alone RB cord-333368-kjrk8nn9 43 3 may may MD cord-333368-kjrk8nn9 43 4 lead lead VB cord-333368-kjrk8nn9 43 5 to to IN cord-333368-kjrk8nn9 43 6 significant significant JJ cord-333368-kjrk8nn9 43 7 changes change NNS cord-333368-kjrk8nn9 43 8 in in IN cord-333368-kjrk8nn9 43 9 macrophage macrophage NN cord-333368-kjrk8nn9 43 10 function function NN cord-333368-kjrk8nn9 43 11 and and CC cord-333368-kjrk8nn9 43 12 inflammation inflammation NN cord-333368-kjrk8nn9 43 13 . . . cord-333368-kjrk8nn9 44 1 In in IN cord-333368-kjrk8nn9 44 2 patients patient NNS cord-333368-kjrk8nn9 44 3 with with IN cord-333368-kjrk8nn9 44 4 diabetes diabete NNS cord-333368-kjrk8nn9 44 5 , , , cord-333368-kjrk8nn9 44 6 increased increase VBN cord-333368-kjrk8nn9 44 7 glucose glucose NN cord-333368-kjrk8nn9 44 8 levels level NNS cord-333368-kjrk8nn9 44 9 and and CC cord-333368-kjrk8nn9 44 10 glycolysis glycolysis NN cord-333368-kjrk8nn9 44 11 promoted promote VBD cord-333368-kjrk8nn9 44 12 Sars Sars NNP cord-333368-kjrk8nn9 44 13 - - HYPH cord-333368-kjrk8nn9 44 14 CoV-2 CoV-2 NNP cord-333368-kjrk8nn9 44 15 replication replication NN cord-333368-kjrk8nn9 44 16 in in IN cord-333368-kjrk8nn9 44 17 monocytes monocyte NNS cord-333368-kjrk8nn9 44 18 via via IN cord-333368-kjrk8nn9 44 19 ROS ROS NNP cord-333368-kjrk8nn9 44 20 / / SYM cord-333368-kjrk8nn9 44 21 HIF HIF NNP cord-333368-kjrk8nn9 44 22 pathway pathway NN cord-333368-kjrk8nn9 44 23 activation activation NN cord-333368-kjrk8nn9 44 24 leading lead VBG cord-333368-kjrk8nn9 44 25 to to IN cord-333368-kjrk8nn9 44 26 secondary secondary JJ cord-333368-kjrk8nn9 44 27 T t NN cord-333368-kjrk8nn9 44 28 - - HYPH cord-333368-kjrk8nn9 44 29 cell cell NN cord-333368-kjrk8nn9 44 30 dysfunction dysfunction NN cord-333368-kjrk8nn9 44 31 37 37 CD cord-333368-kjrk8nn9 44 32 . . . cord-333368-kjrk8nn9 45 1 Patients patient NNS cord-333368-kjrk8nn9 45 2 with with IN cord-333368-kjrk8nn9 45 3 well well RB cord-333368-kjrk8nn9 45 4 controlled control VBN cord-333368-kjrk8nn9 45 5 blood blood NN cord-333368-kjrk8nn9 45 6 glucose glucose NN cord-333368-kjrk8nn9 45 7 levels level NNS cord-333368-kjrk8nn9 45 8 were be VBD cord-333368-kjrk8nn9 45 9 less less RBR cord-333368-kjrk8nn9 45 10 likely likely JJ cord-333368-kjrk8nn9 45 11 to to TO cord-333368-kjrk8nn9 45 12 experience experience VB cord-333368-kjrk8nn9 45 13 serious serious JJ cord-333368-kjrk8nn9 45 14 complications complication NNS cord-333368-kjrk8nn9 45 15 and and CC cord-333368-kjrk8nn9 45 16 death death NN cord-333368-kjrk8nn9 45 17 from from IN cord-333368-kjrk8nn9 45 18 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 45 19 compared compare VBN cord-333368-kjrk8nn9 45 20 to to IN cord-333368-kjrk8nn9 45 21 diabetic diabetic JJ cord-333368-kjrk8nn9 45 22 patients patient NNS cord-333368-kjrk8nn9 45 23 with with IN cord-333368-kjrk8nn9 45 24 poorly poorly RB cord-333368-kjrk8nn9 45 25 controlled control VBN cord-333368-kjrk8nn9 45 26 blood blood NN cord-333368-kjrk8nn9 45 27 glucose glucose NN cord-333368-kjrk8nn9 45 28 levels level NNS cord-333368-kjrk8nn9 45 29 . . . cord-333368-kjrk8nn9 46 1 The the DT cord-333368-kjrk8nn9 46 2 wellcontrolled wellcontrolled JJ cord-333368-kjrk8nn9 46 3 patients patient NNS cord-333368-kjrk8nn9 46 4 had have VBD cord-333368-kjrk8nn9 46 5 lower low JJR cord-333368-kjrk8nn9 46 6 IL-6 IL-6 NNP cord-333368-kjrk8nn9 46 7 , , , cord-333368-kjrk8nn9 46 8 C C NNP cord-333368-kjrk8nn9 46 9 Reactive Reactive NNP cord-333368-kjrk8nn9 46 10 Protein Protein NNP cord-333368-kjrk8nn9 46 11 , , , cord-333368-kjrk8nn9 46 12 and and CC cord-333368-kjrk8nn9 46 13 LDH LDH NNP cord-333368-kjrk8nn9 46 14 levels level NNS cord-333368-kjrk8nn9 46 15 , , , cord-333368-kjrk8nn9 46 16 as as RB cord-333368-kjrk8nn9 46 17 well well RB cord-333368-kjrk8nn9 46 18 as as IN cord-333368-kjrk8nn9 46 19 only only RB cord-333368-kjrk8nn9 46 20 a a DT cord-333368-kjrk8nn9 46 21 1.1 1.1 CD cord-333368-kjrk8nn9 46 22 % % NN cord-333368-kjrk8nn9 46 23 mortality mortality NN cord-333368-kjrk8nn9 46 24 rate rate NN cord-333368-kjrk8nn9 46 25 , , , cord-333368-kjrk8nn9 46 26 which which WDT cord-333368-kjrk8nn9 46 27 is be VBZ cord-333368-kjrk8nn9 46 28 significantly significantly RB cord-333368-kjrk8nn9 46 29 lower low JJR cord-333368-kjrk8nn9 46 30 than than IN cord-333368-kjrk8nn9 46 31 the the DT cord-333368-kjrk8nn9 46 32 11 11 CD cord-333368-kjrk8nn9 46 33 % % NN cord-333368-kjrk8nn9 46 34 mortality mortality NN cord-333368-kjrk8nn9 46 35 rate rate NN cord-333368-kjrk8nn9 46 36 seen see VBN cord-333368-kjrk8nn9 46 37 in in IN cord-333368-kjrk8nn9 46 38 the the DT cord-333368-kjrk8nn9 46 39 poorly poorly RB cord-333368-kjrk8nn9 46 40 controlled control VBN cord-333368-kjrk8nn9 46 41 group group NN cord-333368-kjrk8nn9 46 42 5 5 CD cord-333368-kjrk8nn9 46 43 . . . cord-333368-kjrk8nn9 47 1 This this DT cord-333368-kjrk8nn9 47 2 association association NN cord-333368-kjrk8nn9 47 3 of of IN cord-333368-kjrk8nn9 47 4 diabetes diabetes NNP cord-333368-kjrk8nn9 47 5 diagnosis diagnosis NN cord-333368-kjrk8nn9 47 6 with with IN cord-333368-kjrk8nn9 47 7 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 47 8 mortality mortality NN cord-333368-kjrk8nn9 47 9 is be VBZ cord-333368-kjrk8nn9 47 10 also also RB cord-333368-kjrk8nn9 47 11 observed observe VBN cord-333368-kjrk8nn9 47 12 on on IN cord-333368-kjrk8nn9 47 13 the the DT cord-333368-kjrk8nn9 47 14 population population NN cord-333368-kjrk8nn9 47 15 level level NN cord-333368-kjrk8nn9 47 16 as as RB cord-333368-kjrk8nn9 47 17 well well RB cord-333368-kjrk8nn9 47 18 17 17 CD cord-333368-kjrk8nn9 47 19 . . . cord-333368-kjrk8nn9 48 1 While while IN cord-333368-kjrk8nn9 48 2 one one PRP cord-333368-kjrk8nn9 48 3 can can MD cord-333368-kjrk8nn9 48 4 not not RB cord-333368-kjrk8nn9 48 5 directly directly RB cord-333368-kjrk8nn9 48 6 say say VB cord-333368-kjrk8nn9 48 7 the the DT cord-333368-kjrk8nn9 48 8 hyperglycemia hyperglycemia NN cord-333368-kjrk8nn9 48 9 causes cause VBZ cord-333368-kjrk8nn9 48 10 this this DT cord-333368-kjrk8nn9 48 11 enhanced enhance VBN cord-333368-kjrk8nn9 48 12 mortality mortality NN cord-333368-kjrk8nn9 48 13 , , , cord-333368-kjrk8nn9 48 14 there there EX cord-333368-kjrk8nn9 48 15 is be VBZ cord-333368-kjrk8nn9 48 16 abundant abundant JJ cord-333368-kjrk8nn9 48 17 evidence evidence NN cord-333368-kjrk8nn9 48 18 that that IN cord-333368-kjrk8nn9 48 19 obesity obesity NN cord-333368-kjrk8nn9 48 20 leads lead VBZ cord-333368-kjrk8nn9 48 21 to to IN cord-333368-kjrk8nn9 48 22 long long JJ cord-333368-kjrk8nn9 48 23 - - HYPH cord-333368-kjrk8nn9 48 24 term term NN cord-333368-kjrk8nn9 48 25 reprogramming reprogramming NN cord-333368-kjrk8nn9 48 26 of of IN cord-333368-kjrk8nn9 48 27 the the DT cord-333368-kjrk8nn9 48 28 innate innate JJ cord-333368-kjrk8nn9 48 29 immune immune JJ cord-333368-kjrk8nn9 48 30 system system NN cord-333368-kjrk8nn9 48 31 . . . cord-333368-kjrk8nn9 49 1 Macrophages macrophage NNS cord-333368-kjrk8nn9 49 2 from from IN cord-333368-kjrk8nn9 49 3 obese obese JJ cord-333368-kjrk8nn9 49 4 animals animal NNS cord-333368-kjrk8nn9 49 5 and and CC cord-333368-kjrk8nn9 49 6 humans human NNS cord-333368-kjrk8nn9 49 7 have have VBP cord-333368-kjrk8nn9 49 8 been be VBN cord-333368-kjrk8nn9 49 9 described describe VBN cord-333368-kjrk8nn9 49 10 as as IN cord-333368-kjrk8nn9 49 11 metabolically metabolically RB cord-333368-kjrk8nn9 49 12 active active JJ cord-333368-kjrk8nn9 49 13 , , , cord-333368-kjrk8nn9 49 14 M1 M1 NNP cord-333368-kjrk8nn9 49 15 polarized polarize VBD cord-333368-kjrk8nn9 49 16 , , , cord-333368-kjrk8nn9 49 17 and and CC cord-333368-kjrk8nn9 49 18 pro pro JJ cord-333368-kjrk8nn9 49 19 - - JJ cord-333368-kjrk8nn9 49 20 inflammatory inflammatory JJ cord-333368-kjrk8nn9 49 21 with with IN cord-333368-kjrk8nn9 49 22 both both CC cord-333368-kjrk8nn9 49 23 regulatory regulatory JJ cord-333368-kjrk8nn9 49 24 and and CC cord-333368-kjrk8nn9 49 25 detrimental detrimental JJ cord-333368-kjrk8nn9 49 26 activity activity NN cord-333368-kjrk8nn9 49 27 [ [ -LRB- cord-333368-kjrk8nn9 49 28 38 38 CD cord-333368-kjrk8nn9 49 29 ] ] -RRB- cord-333368-kjrk8nn9 49 30 [ [ -LRB- cord-333368-kjrk8nn9 49 31 39 39 CD cord-333368-kjrk8nn9 49 32 ] ] -RRB- cord-333368-kjrk8nn9 49 33 [ [ -LRB- cord-333368-kjrk8nn9 49 34 40 40 CD cord-333368-kjrk8nn9 49 35 ] ] -RRB- cord-333368-kjrk8nn9 49 36 . . . cord-333368-kjrk8nn9 50 1 These these DT cord-333368-kjrk8nn9 50 2 macrophages macrophage NNS cord-333368-kjrk8nn9 50 3 produce produce VBP cord-333368-kjrk8nn9 50 4 cytokines cytokine NNS cord-333368-kjrk8nn9 50 5 , , , cord-333368-kjrk8nn9 50 6 chemokines chemokine NNS cord-333368-kjrk8nn9 50 7 , , , cord-333368-kjrk8nn9 50 8 reactive reactive JJ cord-333368-kjrk8nn9 50 9 oxygen oxygen NN cord-333368-kjrk8nn9 50 10 species specie NNS cord-333368-kjrk8nn9 50 11 , , , cord-333368-kjrk8nn9 50 12 and and CC cord-333368-kjrk8nn9 50 13 factors factor NNS cord-333368-kjrk8nn9 50 14 regulating regulate VBG cord-333368-kjrk8nn9 50 15 fibrosis fibrosis NN cord-333368-kjrk8nn9 50 16 and and CC cord-333368-kjrk8nn9 50 17 metabolism metabolism NN cord-333368-kjrk8nn9 50 18 . . . cord-333368-kjrk8nn9 51 1 Overall overall RB cord-333368-kjrk8nn9 51 2 , , , cord-333368-kjrk8nn9 51 3 our -PRON- PRP$ cord-333368-kjrk8nn9 51 4 understanding understanding NN cord-333368-kjrk8nn9 51 5 is be VBZ cord-333368-kjrk8nn9 51 6 that that IN cord-333368-kjrk8nn9 51 7 these these DT cord-333368-kjrk8nn9 51 8 metabolic metabolic JJ cord-333368-kjrk8nn9 51 9 macrophages macrophage NNS cord-333368-kjrk8nn9 51 10 have have VBP cord-333368-kjrk8nn9 51 11 a a DT cord-333368-kjrk8nn9 51 12 similar similar JJ cord-333368-kjrk8nn9 51 13 profile profile NN cord-333368-kjrk8nn9 51 14 to to IN cord-333368-kjrk8nn9 51 15 those those DT cord-333368-kjrk8nn9 51 16 stimulated stimulate VBN cord-333368-kjrk8nn9 51 17 with with IN cord-333368-kjrk8nn9 51 18 lipopolysaccharide lipopolysaccharide NN cord-333368-kjrk8nn9 51 19 ( ( -LRB- cord-333368-kjrk8nn9 51 20 LPS LPS NNP cord-333368-kjrk8nn9 51 21 ) ) -RRB- cord-333368-kjrk8nn9 51 22 , , , cord-333368-kjrk8nn9 51 23 an an DT cord-333368-kjrk8nn9 51 24 abundant abundant JJ cord-333368-kjrk8nn9 51 25 bacterial bacterial NN cord-333368-kjrk8nn9 51 26 derived derive VBN cord-333368-kjrk8nn9 51 27 A a NN cord-333368-kjrk8nn9 51 28 c c NN cord-333368-kjrk8nn9 51 29 c c NN cord-333368-kjrk8nn9 51 30 e e NN cord-333368-kjrk8nn9 51 31 p p NN cord-333368-kjrk8nn9 51 32 t t NN cord-333368-kjrk8nn9 51 33 e e NN cord-333368-kjrk8nn9 51 34 d d NNP cord-333368-kjrk8nn9 51 35 M M NNP cord-333368-kjrk8nn9 51 36 a a NNP cord-333368-kjrk8nn9 51 37 n n NN cord-333368-kjrk8nn9 51 38 u u NNP cord-333368-kjrk8nn9 51 39 s s NN cord-333368-kjrk8nn9 51 40 c c NN cord-333368-kjrk8nn9 51 41 r r NN cord-333368-kjrk8nn9 52 1 i i NN cord-333368-kjrk8nn9 52 2 p p NN cord-333368-kjrk8nn9 52 3 t t NNP cord-333368-kjrk8nn9 52 4 7 7 CD cord-333368-kjrk8nn9 52 5 molecular molecular JJ cord-333368-kjrk8nn9 52 6 pattern pattern NN cord-333368-kjrk8nn9 52 7 molecule molecule NN cord-333368-kjrk8nn9 52 8 and and CC cord-333368-kjrk8nn9 52 9 ligand ligand NN cord-333368-kjrk8nn9 52 10 of of IN cord-333368-kjrk8nn9 52 11 the the DT cord-333368-kjrk8nn9 52 12 Toll Toll NNP cord-333368-kjrk8nn9 52 13 - - HYPH cord-333368-kjrk8nn9 52 14 like like JJ cord-333368-kjrk8nn9 52 15 receptor receptor NN cord-333368-kjrk8nn9 52 16 4 4 CD cord-333368-kjrk8nn9 52 17 ( ( -LRB- cord-333368-kjrk8nn9 52 18 TLR4 TLR4 NNP cord-333368-kjrk8nn9 52 19 ) ) -RRB- cord-333368-kjrk8nn9 52 20 . . . cord-333368-kjrk8nn9 53 1 More more RBR cord-333368-kjrk8nn9 53 2 recently recently RB cord-333368-kjrk8nn9 53 3 it -PRON- PRP cord-333368-kjrk8nn9 53 4 has have VBZ cord-333368-kjrk8nn9 53 5 become become VBN cord-333368-kjrk8nn9 53 6 clear clear JJ cord-333368-kjrk8nn9 53 7 that that IN cord-333368-kjrk8nn9 53 8 while while IN cord-333368-kjrk8nn9 53 9 the the DT cord-333368-kjrk8nn9 53 10 inflammatory inflammatory JJ cord-333368-kjrk8nn9 53 11 phenotype phenotype NN cord-333368-kjrk8nn9 53 12 of of IN cord-333368-kjrk8nn9 53 13 these these DT cord-333368-kjrk8nn9 53 14 macrophages macrophage NNS cord-333368-kjrk8nn9 53 15 is be VBZ cord-333368-kjrk8nn9 53 16 closest close JJS cord-333368-kjrk8nn9 53 17 to to IN cord-333368-kjrk8nn9 53 18 what what WP cord-333368-kjrk8nn9 53 19 is be VBZ cord-333368-kjrk8nn9 53 20 seen see VBN cord-333368-kjrk8nn9 53 21 with with IN cord-333368-kjrk8nn9 53 22 LPS LPS NNP cord-333368-kjrk8nn9 53 23 stimulation stimulation NN cord-333368-kjrk8nn9 53 24 , , , cord-333368-kjrk8nn9 53 25 traditional traditional JJ cord-333368-kjrk8nn9 53 26 M1 M1 NNP cord-333368-kjrk8nn9 53 27 macrophages macrophage NNS cord-333368-kjrk8nn9 53 28 , , , cord-333368-kjrk8nn9 53 29 the the DT cord-333368-kjrk8nn9 53 30 added add VBN cord-333368-kjrk8nn9 53 31 activation activation NN cord-333368-kjrk8nn9 53 32 by by IN cord-333368-kjrk8nn9 53 33 fatty fatty JJ cord-333368-kjrk8nn9 53 34 acids acid NNS cord-333368-kjrk8nn9 53 35 creates create VBZ cord-333368-kjrk8nn9 53 36 a a DT cord-333368-kjrk8nn9 53 37 unique unique JJ cord-333368-kjrk8nn9 53 38 phenotype phenotype NN cord-333368-kjrk8nn9 53 39 that that WDT cord-333368-kjrk8nn9 53 40 has have VBZ cord-333368-kjrk8nn9 53 41 characterized characterize VBN cord-333368-kjrk8nn9 53 42 these these DT cord-333368-kjrk8nn9 53 43 obesity obesity NN cord-333368-kjrk8nn9 53 44 myeloid myeloid NN cord-333368-kjrk8nn9 53 45 cells cell NNS cord-333368-kjrk8nn9 53 46 as as IN cord-333368-kjrk8nn9 53 47 metabolically metabolically RB cord-333368-kjrk8nn9 53 48 active active JJ cord-333368-kjrk8nn9 53 49 macrophages macrophage NNS cord-333368-kjrk8nn9 53 50 41 41 CD cord-333368-kjrk8nn9 53 51 . . . cord-333368-kjrk8nn9 54 1 While while IN cord-333368-kjrk8nn9 54 2 changes change NNS cord-333368-kjrk8nn9 54 3 to to IN cord-333368-kjrk8nn9 54 4 macrophage macrophage NN cord-333368-kjrk8nn9 54 5 phenotype phenotype NN cord-333368-kjrk8nn9 54 6 in in IN cord-333368-kjrk8nn9 54 7 obesity obesity NN cord-333368-kjrk8nn9 54 8 were be VBD cord-333368-kjrk8nn9 54 9 originally originally RB cord-333368-kjrk8nn9 54 10 characterized characterize VBN cord-333368-kjrk8nn9 54 11 in in IN cord-333368-kjrk8nn9 54 12 the the DT cord-333368-kjrk8nn9 54 13 adipose adipose JJ cord-333368-kjrk8nn9 54 14 tissue tissue NN cord-333368-kjrk8nn9 54 15 36 36 CD cord-333368-kjrk8nn9 54 16 , , , cord-333368-kjrk8nn9 54 17 42 42 CD cord-333368-kjrk8nn9 54 18 , , , cord-333368-kjrk8nn9 54 19 it -PRON- PRP cord-333368-kjrk8nn9 54 20 is be VBZ cord-333368-kjrk8nn9 54 21 now now RB cord-333368-kjrk8nn9 54 22 evident evident JJ cord-333368-kjrk8nn9 54 23 that that IN cord-333368-kjrk8nn9 54 24 obesity obesity NN cord-333368-kjrk8nn9 54 25 has have VBZ cord-333368-kjrk8nn9 54 26 significant significant JJ cord-333368-kjrk8nn9 54 27 effects effect NNS cord-333368-kjrk8nn9 54 28 on on IN cord-333368-kjrk8nn9 54 29 hematopoiesis hematopoiesis NN cord-333368-kjrk8nn9 54 30 , , , cord-333368-kjrk8nn9 54 31 circulating circulate VBG cord-333368-kjrk8nn9 54 32 monocytes monocyte NNS cord-333368-kjrk8nn9 54 33 , , , cord-333368-kjrk8nn9 54 34 and and CC cord-333368-kjrk8nn9 54 35 macrophages macrophage NNS cord-333368-kjrk8nn9 54 36 in in IN cord-333368-kjrk8nn9 54 37 multiple multiple JJ cord-333368-kjrk8nn9 54 38 organs organ NNS cord-333368-kjrk8nn9 54 39 . . . cord-333368-kjrk8nn9 55 1 Elevated elevated JJ cord-333368-kjrk8nn9 55 2 BMI BMI NNP cord-333368-kjrk8nn9 55 3 and and CC cord-333368-kjrk8nn9 55 4 obesity obesity NN cord-333368-kjrk8nn9 55 5 has have VBZ cord-333368-kjrk8nn9 55 6 been be VBN cord-333368-kjrk8nn9 55 7 shown show VBN cord-333368-kjrk8nn9 55 8 to to TO cord-333368-kjrk8nn9 55 9 enhance enhance VB cord-333368-kjrk8nn9 55 10 hematopoiesis hematopoiesis NN cord-333368-kjrk8nn9 55 11 and and CC cord-333368-kjrk8nn9 55 12 expand expand VB cord-333368-kjrk8nn9 55 13 myeloid myeloid JJ cord-333368-kjrk8nn9 55 14 cell cell NN cord-333368-kjrk8nn9 55 15 production production NN cord-333368-kjrk8nn9 56 1 43,44 43,44 CD cord-333368-kjrk8nn9 57 1 but but CC cord-333368-kjrk8nn9 57 2 it -PRON- PRP cord-333368-kjrk8nn9 57 3 has have VBZ cord-333368-kjrk8nn9 57 4 also also RB cord-333368-kjrk8nn9 57 5 been be VBN cord-333368-kjrk8nn9 57 6 shown show VBN cord-333368-kjrk8nn9 57 7 to to TO cord-333368-kjrk8nn9 57 8 impair impair VB cord-333368-kjrk8nn9 57 9 immune immune JJ cord-333368-kjrk8nn9 57 10 responses response NNS cord-333368-kjrk8nn9 57 11 in in IN cord-333368-kjrk8nn9 57 12 a a DT cord-333368-kjrk8nn9 57 13 TLR4 TLR4 NNP cord-333368-kjrk8nn9 57 14 dependent dependent JJ cord-333368-kjrk8nn9 57 15 manner manner NN cord-333368-kjrk8nn9 57 16 45 45 CD cord-333368-kjrk8nn9 57 17 . . . cord-333368-kjrk8nn9 58 1 High high JJ cord-333368-kjrk8nn9 58 2 fat fat JJ cord-333368-kjrk8nn9 58 3 diet diet NN cord-333368-kjrk8nn9 58 4 increases increase VBZ cord-333368-kjrk8nn9 58 5 the the DT cord-333368-kjrk8nn9 58 6 number number NN cord-333368-kjrk8nn9 58 7 of of IN cord-333368-kjrk8nn9 58 8 monocytes monocyte NNS cord-333368-kjrk8nn9 58 9 in in IN cord-333368-kjrk8nn9 58 10 circulation circulation NN cord-333368-kjrk8nn9 58 11 and and CC cord-333368-kjrk8nn9 58 12 expands expand VBZ cord-333368-kjrk8nn9 58 13 bone bone NN cord-333368-kjrk8nn9 58 14 marrow marrow NN cord-333368-kjrk8nn9 58 15 macrophages macrophage NNS cord-333368-kjrk8nn9 58 16 , , , cord-333368-kjrk8nn9 58 17 neutrophils neutrophil NNS cord-333368-kjrk8nn9 58 18 and and CC cord-333368-kjrk8nn9 58 19 their -PRON- PRP$ cord-333368-kjrk8nn9 58 20 progenitors progenitor NNS cord-333368-kjrk8nn9 58 21 43 43 CD cord-333368-kjrk8nn9 58 22 . . . cord-333368-kjrk8nn9 59 1 Expansion expansion NN cord-333368-kjrk8nn9 59 2 of of IN cord-333368-kjrk8nn9 59 3 these these DT cord-333368-kjrk8nn9 59 4 progenitors progenitor NNS cord-333368-kjrk8nn9 59 5 leads lead VBZ cord-333368-kjrk8nn9 59 6 to to IN cord-333368-kjrk8nn9 59 7 increased increase VBN cord-333368-kjrk8nn9 59 8 macrophage macrophage NN cord-333368-kjrk8nn9 59 9 production production NN cord-333368-kjrk8nn9 59 10 , , , cord-333368-kjrk8nn9 59 11 but but CC cord-333368-kjrk8nn9 59 12 also also RB cord-333368-kjrk8nn9 59 13 skews skew VBZ cord-333368-kjrk8nn9 59 14 the the DT cord-333368-kjrk8nn9 59 15 resulting result VBG cord-333368-kjrk8nn9 59 16 macrophage macrophage NN cord-333368-kjrk8nn9 59 17 population population NN cord-333368-kjrk8nn9 59 18 to to IN cord-333368-kjrk8nn9 59 19 a a DT cord-333368-kjrk8nn9 59 20 pro pro JJ cord-333368-kjrk8nn9 59 21 - - JJ cord-333368-kjrk8nn9 59 22 inflammatory inflammatory JJ cord-333368-kjrk8nn9 59 23 phenotype phenotype NN cord-333368-kjrk8nn9 59 24 43 43 CD cord-333368-kjrk8nn9 59 25 , , , cord-333368-kjrk8nn9 59 26 44 44 CD cord-333368-kjrk8nn9 59 27 , , , cord-333368-kjrk8nn9 59 28 46 46 CD cord-333368-kjrk8nn9 59 29 . . . cord-333368-kjrk8nn9 60 1 During during IN cord-333368-kjrk8nn9 60 2 obesity obesity NN cord-333368-kjrk8nn9 60 3 there there EX cord-333368-kjrk8nn9 60 4 is be VBZ cord-333368-kjrk8nn9 60 5 an an DT cord-333368-kjrk8nn9 60 6 overall overall JJ cord-333368-kjrk8nn9 60 7 increase increase NN cord-333368-kjrk8nn9 60 8 in in IN cord-333368-kjrk8nn9 60 9 chemokines chemokine NNS cord-333368-kjrk8nn9 60 10 , , , cord-333368-kjrk8nn9 60 11 which which WDT cord-333368-kjrk8nn9 60 12 play play VBP cord-333368-kjrk8nn9 60 13 a a DT cord-333368-kjrk8nn9 60 14 role role NN cord-333368-kjrk8nn9 60 15 in in IN cord-333368-kjrk8nn9 60 16 metabolic metabolic JJ cord-333368-kjrk8nn9 60 17 inflammation inflammation NN cord-333368-kjrk8nn9 60 18 by by IN cord-333368-kjrk8nn9 60 19 recruiting recruit VBG cord-333368-kjrk8nn9 60 20 monocytes monocyte NNS cord-333368-kjrk8nn9 60 21 into into IN cord-333368-kjrk8nn9 60 22 adipose adipose JJ cord-333368-kjrk8nn9 60 23 tissue tissue NN cord-333368-kjrk8nn9 60 24 . . . cord-333368-kjrk8nn9 61 1 Additionally additionally RB cord-333368-kjrk8nn9 61 2 , , , cord-333368-kjrk8nn9 61 3 during during IN cord-333368-kjrk8nn9 61 4 obesity obesity NN cord-333368-kjrk8nn9 61 5 and and CC cord-333368-kjrk8nn9 61 6 type type NN cord-333368-kjrk8nn9 61 7 2 2 CD cord-333368-kjrk8nn9 61 8 diabetes diabetes NN cord-333368-kjrk8nn9 61 9 ( ( -LRB- cord-333368-kjrk8nn9 61 10 T2D t2d CD cord-333368-kjrk8nn9 61 11 ) ) -RRB- cord-333368-kjrk8nn9 61 12 , , , cord-333368-kjrk8nn9 61 13 there there EX cord-333368-kjrk8nn9 61 14 is be VBZ cord-333368-kjrk8nn9 61 15 an an DT cord-333368-kjrk8nn9 61 16 increase increase NN cord-333368-kjrk8nn9 61 17 in in IN cord-333368-kjrk8nn9 61 18 circulation circulation NN cord-333368-kjrk8nn9 61 19 of of IN cord-333368-kjrk8nn9 61 20 free free JJ cord-333368-kjrk8nn9 61 21 fatty fatty JJ cord-333368-kjrk8nn9 61 22 acids acid NNS cord-333368-kjrk8nn9 61 23 ( ( -LRB- cord-333368-kjrk8nn9 61 24 FFAs FFAs NNP cord-333368-kjrk8nn9 61 25 ) ) -RRB- cord-333368-kjrk8nn9 61 26 , , , cord-333368-kjrk8nn9 61 27 including include VBG cord-333368-kjrk8nn9 61 28 palmitate palmitate NN cord-333368-kjrk8nn9 61 29 ( ( -LRB- cord-333368-kjrk8nn9 61 30 PA PA NNP cord-333368-kjrk8nn9 61 31 ) ) -RRB- cord-333368-kjrk8nn9 61 32 . . . cord-333368-kjrk8nn9 62 1 PA PA NNP cord-333368-kjrk8nn9 62 2 induces induce VBZ cord-333368-kjrk8nn9 62 3 CCL4 CCL4 NNP cord-333368-kjrk8nn9 62 4 release release NN cord-333368-kjrk8nn9 62 5 from from IN cord-333368-kjrk8nn9 62 6 monocytes monocyte NNS cord-333368-kjrk8nn9 62 7 and and CC cord-333368-kjrk8nn9 62 8 macrophages macrophage NNS cord-333368-kjrk8nn9 62 9 by by IN cord-333368-kjrk8nn9 62 10 interacting interact VBG cord-333368-kjrk8nn9 62 11 with with IN cord-333368-kjrk8nn9 62 12 TLR4 TLR4 NNP cord-333368-kjrk8nn9 62 13 47 47 CD cord-333368-kjrk8nn9 62 14 . . . cord-333368-kjrk8nn9 63 1 Obese obese JJ cord-333368-kjrk8nn9 63 2 individuals individual NNS cord-333368-kjrk8nn9 63 3 , , , cord-333368-kjrk8nn9 63 4 regardless regardless RB cord-333368-kjrk8nn9 63 5 of of IN cord-333368-kjrk8nn9 63 6 diabetes diabetes NN cord-333368-kjrk8nn9 63 7 status status NN cord-333368-kjrk8nn9 63 8 , , , cord-333368-kjrk8nn9 63 9 also also RB cord-333368-kjrk8nn9 63 10 have have VBP cord-333368-kjrk8nn9 63 11 higher high JJR cord-333368-kjrk8nn9 63 12 circulating circulate VBG cord-333368-kjrk8nn9 63 13 levels level NNS cord-333368-kjrk8nn9 63 14 of of IN cord-333368-kjrk8nn9 63 15 LPS LPS NNP cord-333368-kjrk8nn9 63 16 48,49 48,49 CD cord-333368-kjrk8nn9 63 17 which which WDT cord-333368-kjrk8nn9 63 18 binds bind VBZ cord-333368-kjrk8nn9 63 19 to to IN cord-333368-kjrk8nn9 63 20 TLR4 TLR4 NNP cord-333368-kjrk8nn9 63 21 . . . cord-333368-kjrk8nn9 64 1 This this DT cord-333368-kjrk8nn9 64 2 binding binding NN cord-333368-kjrk8nn9 64 3 increases increase VBZ cord-333368-kjrk8nn9 64 4 the the DT cord-333368-kjrk8nn9 64 5 production production NN cord-333368-kjrk8nn9 64 6 of of IN cord-333368-kjrk8nn9 64 7 the the DT cord-333368-kjrk8nn9 64 8 chemokine chemokine NN cord-333368-kjrk8nn9 64 9 CCL2 CCL2 NNP cord-333368-kjrk8nn9 64 10 in in IN cord-333368-kjrk8nn9 64 11 monocytes monocyte NNS cord-333368-kjrk8nn9 64 12 and and CC cord-333368-kjrk8nn9 64 13 macrophages macrophage NNS cord-333368-kjrk8nn9 64 14 50 50 CD cord-333368-kjrk8nn9 64 15 . . . cord-333368-kjrk8nn9 65 1 This this DT cord-333368-kjrk8nn9 65 2 further further JJ cord-333368-kjrk8nn9 65 3 leads lead VBZ cord-333368-kjrk8nn9 65 4 to to IN cord-333368-kjrk8nn9 65 5 enhanced enhanced JJ cord-333368-kjrk8nn9 65 6 tissue tissue NN cord-333368-kjrk8nn9 65 7 macrophages macrophage NNS cord-333368-kjrk8nn9 65 8 that that WDT cord-333368-kjrk8nn9 65 9 have have VBP cord-333368-kjrk8nn9 65 10 the the DT cord-333368-kjrk8nn9 65 11 potential potential NN cord-333368-kjrk8nn9 65 12 to to TO cord-333368-kjrk8nn9 65 13 lead lead VB cord-333368-kjrk8nn9 65 14 to to IN cord-333368-kjrk8nn9 65 15 dysfunctional dysfunctional JJ cord-333368-kjrk8nn9 65 16 cytokine cytokine NN cord-333368-kjrk8nn9 65 17 production production NN cord-333368-kjrk8nn9 65 18 and and CC cord-333368-kjrk8nn9 65 19 tissue tissue NN cord-333368-kjrk8nn9 65 20 damage damage NN cord-333368-kjrk8nn9 65 21 if if IN cord-333368-kjrk8nn9 65 22 triggered trigger VBN cord-333368-kjrk8nn9 65 23 . . . cord-333368-kjrk8nn9 66 1 A a DT cord-333368-kjrk8nn9 66 2 c c NN cord-333368-kjrk8nn9 66 3 c c NN cord-333368-kjrk8nn9 66 4 e e NN cord-333368-kjrk8nn9 66 5 p p NN cord-333368-kjrk8nn9 66 6 t t NN cord-333368-kjrk8nn9 66 7 e e NN cord-333368-kjrk8nn9 66 8 d d NNP cord-333368-kjrk8nn9 66 9 M M NNP cord-333368-kjrk8nn9 66 10 a a NNP cord-333368-kjrk8nn9 66 11 n n NN cord-333368-kjrk8nn9 66 12 u u NNP cord-333368-kjrk8nn9 66 13 s s NNP cord-333368-kjrk8nn9 66 14 c c NN cord-333368-kjrk8nn9 66 15 r r NN cord-333368-kjrk8nn9 66 16 i i NN cord-333368-kjrk8nn9 66 17 p p NN cord-333368-kjrk8nn9 66 18 t t NN cord-333368-kjrk8nn9 66 19 8 8 CD cord-333368-kjrk8nn9 66 20 While while IN cord-333368-kjrk8nn9 66 21 the the DT cord-333368-kjrk8nn9 66 22 phenotype phenotype NN cord-333368-kjrk8nn9 66 23 of of IN cord-333368-kjrk8nn9 66 24 these these DT cord-333368-kjrk8nn9 66 25 macrophages macrophage NNS cord-333368-kjrk8nn9 66 26 in in IN cord-333368-kjrk8nn9 66 27 driving drive VBG cord-333368-kjrk8nn9 66 28 impaired impaired JJ cord-333368-kjrk8nn9 66 29 metabolism metabolism NN cord-333368-kjrk8nn9 66 30 is be VBZ cord-333368-kjrk8nn9 66 31 well well RB cord-333368-kjrk8nn9 66 32 described describe VBN cord-333368-kjrk8nn9 66 33 there there EX cord-333368-kjrk8nn9 66 34 are be VBP cord-333368-kjrk8nn9 66 35 several several JJ cord-333368-kjrk8nn9 66 36 other other JJ cord-333368-kjrk8nn9 66 37 implications implication NNS cord-333368-kjrk8nn9 66 38 of of IN cord-333368-kjrk8nn9 66 39 these these DT cord-333368-kjrk8nn9 66 40 metabolically metabolically RB cord-333368-kjrk8nn9 66 41 activated activate VBN cord-333368-kjrk8nn9 66 42 macrophages macrophage NNS cord-333368-kjrk8nn9 66 43 51 51 CD cord-333368-kjrk8nn9 66 44 . . . cord-333368-kjrk8nn9 67 1 In in IN cord-333368-kjrk8nn9 67 2 pulmonary pulmonary JJ cord-333368-kjrk8nn9 67 3 viral viral JJ cord-333368-kjrk8nn9 67 4 infections infection NNS cord-333368-kjrk8nn9 67 5 such such JJ cord-333368-kjrk8nn9 67 6 as as IN cord-333368-kjrk8nn9 67 7 influenza influenza NN cord-333368-kjrk8nn9 67 8 , , , cord-333368-kjrk8nn9 67 9 macrophages macrophage NNS cord-333368-kjrk8nn9 67 10 from from IN cord-333368-kjrk8nn9 67 11 obese obese JJ cord-333368-kjrk8nn9 67 12 mice mouse NNS cord-333368-kjrk8nn9 67 13 exhibit exhibit NN cord-333368-kjrk8nn9 67 14 enhanced enhance VBN cord-333368-kjrk8nn9 67 15 and and CC cord-333368-kjrk8nn9 67 16 likely likely JJ cord-333368-kjrk8nn9 67 17 injurious injurious JJ cord-333368-kjrk8nn9 67 18 pro pro JJ cord-333368-kjrk8nn9 67 19 - - JJ cord-333368-kjrk8nn9 67 20 inflammatory inflammatory JJ cord-333368-kjrk8nn9 67 21 cytokine cytokine NN cord-333368-kjrk8nn9 67 22 production production NN cord-333368-kjrk8nn9 67 23 but but CC cord-333368-kjrk8nn9 67 24 impaired impaired JJ cord-333368-kjrk8nn9 67 25 production production NN cord-333368-kjrk8nn9 67 26 of of IN cord-333368-kjrk8nn9 67 27 antiviral antiviral JJ cord-333368-kjrk8nn9 67 28 type type NN cord-333368-kjrk8nn9 67 29 - - : cord-333368-kjrk8nn9 67 30 I -PRON- PRP cord-333368-kjrk8nn9 67 31 interferons interferon NNS cord-333368-kjrk8nn9 67 32 52 52 CD cord-333368-kjrk8nn9 67 33 , , , cord-333368-kjrk8nn9 67 34 53 53 CD cord-333368-kjrk8nn9 67 35 . . . cord-333368-kjrk8nn9 68 1 Obese obese JJ cord-333368-kjrk8nn9 68 2 mice mouse NNS cord-333368-kjrk8nn9 68 3 suffer suffer VBP cord-333368-kjrk8nn9 68 4 increased increase VBN cord-333368-kjrk8nn9 68 5 interstitial interstitial JJ cord-333368-kjrk8nn9 68 6 inflammation inflammation NN cord-333368-kjrk8nn9 68 7 , , , cord-333368-kjrk8nn9 68 8 alveolar alveolar JJ cord-333368-kjrk8nn9 68 9 permeability permeability NN cord-333368-kjrk8nn9 68 10 , , , cord-333368-kjrk8nn9 68 11 and and CC cord-333368-kjrk8nn9 68 12 lung lung NN cord-333368-kjrk8nn9 68 13 injury injury NN cord-333368-kjrk8nn9 68 14 even even RB cord-333368-kjrk8nn9 68 15 in in IN cord-333368-kjrk8nn9 68 16 the the DT cord-333368-kjrk8nn9 68 17 absence absence NN cord-333368-kjrk8nn9 68 18 of of IN cord-333368-kjrk8nn9 68 19 increased increase VBN cord-333368-kjrk8nn9 68 20 viral viral JJ cord-333368-kjrk8nn9 68 21 load load NN cord-333368-kjrk8nn9 68 22 54 54 CD cord-333368-kjrk8nn9 68 23 . . . cord-333368-kjrk8nn9 69 1 Chronic chronic JJ cord-333368-kjrk8nn9 69 2 systemic systemic JJ cord-333368-kjrk8nn9 69 3 inflammation inflammation NN cord-333368-kjrk8nn9 69 4 is be VBZ cord-333368-kjrk8nn9 69 5 accompanied accompany VBN cord-333368-kjrk8nn9 69 6 by by IN cord-333368-kjrk8nn9 69 7 impaired impaired JJ cord-333368-kjrk8nn9 69 8 induction induction NN cord-333368-kjrk8nn9 69 9 of of IN cord-333368-kjrk8nn9 69 10 pathogen pathogen NN cord-333368-kjrk8nn9 69 11 - - HYPH cord-333368-kjrk8nn9 69 12 induced induce VBN cord-333368-kjrk8nn9 69 13 and and CC cord-333368-kjrk8nn9 69 14 lung lung NN cord-333368-kjrk8nn9 69 15 - - HYPH cord-333368-kjrk8nn9 69 16 specific specific JJ cord-333368-kjrk8nn9 69 17 responses response NNS cord-333368-kjrk8nn9 69 18 to to IN cord-333368-kjrk8nn9 69 19 influenza influenza VB cord-333368-kjrk8nn9 69 20 across across IN cord-333368-kjrk8nn9 69 21 a a DT cord-333368-kjrk8nn9 69 22 variety variety NN cord-333368-kjrk8nn9 69 23 of of IN cord-333368-kjrk8nn9 69 24 obesity obesity NN cord-333368-kjrk8nn9 69 25 models model NNS cord-333368-kjrk8nn9 69 26 55 55 CD cord-333368-kjrk8nn9 69 27 . . . cord-333368-kjrk8nn9 70 1 Pro pro JJ cord-333368-kjrk8nn9 70 2 - - JJ cord-333368-kjrk8nn9 70 3 inflammatory inflammatory JJ cord-333368-kjrk8nn9 70 4 activation activation NN cord-333368-kjrk8nn9 70 5 of of IN cord-333368-kjrk8nn9 70 6 macrophages macrophage NNS cord-333368-kjrk8nn9 70 7 in in IN cord-333368-kjrk8nn9 70 8 obesity obesity NN cord-333368-kjrk8nn9 70 9 impairs impair VBZ cord-333368-kjrk8nn9 70 10 their -PRON- PRP$ cord-333368-kjrk8nn9 70 11 function function NN cord-333368-kjrk8nn9 70 12 in in IN cord-333368-kjrk8nn9 70 13 other other JJ cord-333368-kjrk8nn9 70 14 domains domain NNS cord-333368-kjrk8nn9 70 15 , , , cord-333368-kjrk8nn9 70 16 as as RB cord-333368-kjrk8nn9 70 17 well well RB cord-333368-kjrk8nn9 70 18 . . . cord-333368-kjrk8nn9 71 1 For for IN cord-333368-kjrk8nn9 71 2 example example NN cord-333368-kjrk8nn9 71 3 , , , cord-333368-kjrk8nn9 71 4 in in IN cord-333368-kjrk8nn9 71 5 obese obese JJ cord-333368-kjrk8nn9 71 6 diabetic diabetic JJ cord-333368-kjrk8nn9 71 7 mice mouse NNS cord-333368-kjrk8nn9 71 8 , , , cord-333368-kjrk8nn9 71 9 macrophages macrophage NNS cord-333368-kjrk8nn9 71 10 recruited recruit VBN cord-333368-kjrk8nn9 71 11 to to IN cord-333368-kjrk8nn9 71 12 diabetic diabetic JJ cord-333368-kjrk8nn9 71 13 wounds wound NNS cord-333368-kjrk8nn9 71 14 as as IN cord-333368-kjrk8nn9 71 15 a a DT cord-333368-kjrk8nn9 71 16 result result NN cord-333368-kjrk8nn9 71 17 of of IN cord-333368-kjrk8nn9 71 18 epigenetic epigenetic JJ cord-333368-kjrk8nn9 71 19 alterations alteration NNS cord-333368-kjrk8nn9 71 20 have have VBP cord-333368-kjrk8nn9 71 21 a a DT cord-333368-kjrk8nn9 71 22 pro pro JJ cord-333368-kjrk8nn9 71 23 - - JJ cord-333368-kjrk8nn9 71 24 inflammatory inflammatory JJ cord-333368-kjrk8nn9 71 25 phenotype phenotype NN cord-333368-kjrk8nn9 71 26 and and CC cord-333368-kjrk8nn9 71 27 have have VBP cord-333368-kjrk8nn9 71 28 elevated elevate VBN cord-333368-kjrk8nn9 71 29 levels level NNS cord-333368-kjrk8nn9 71 30 of of IN cord-333368-kjrk8nn9 71 31 prostaglandin prostaglandin NN cord-333368-kjrk8nn9 71 32 E e NN cord-333368-kjrk8nn9 71 33 2 2 CD cord-333368-kjrk8nn9 71 34 ( ( -LRB- cord-333368-kjrk8nn9 71 35 PGE PGE NNP cord-333368-kjrk8nn9 71 36 2 2 CD cord-333368-kjrk8nn9 71 37 ) ) -RRB- cord-333368-kjrk8nn9 71 38 production production NN cord-333368-kjrk8nn9 71 39 [ [ -LRB- cord-333368-kjrk8nn9 71 40 56 56 CD cord-333368-kjrk8nn9 71 41 ] ] -RRB- cord-333368-kjrk8nn9 72 1 [ [ -LRB- cord-333368-kjrk8nn9 72 2 57 57 CD cord-333368-kjrk8nn9 72 3 ] ] -RRB- cord-333368-kjrk8nn9 72 4 [ [ -LRB- cord-333368-kjrk8nn9 72 5 58 58 CD cord-333368-kjrk8nn9 72 6 ] ] -RRB- cord-333368-kjrk8nn9 73 1 [ [ -LRB- cord-333368-kjrk8nn9 73 2 59 59 CD cord-333368-kjrk8nn9 73 3 ] ] -RRB- cord-333368-kjrk8nn9 73 4 [ [ -LRB- cord-333368-kjrk8nn9 73 5 60 60 CD cord-333368-kjrk8nn9 73 6 ] ] -RRB- cord-333368-kjrk8nn9 73 7 . . . cord-333368-kjrk8nn9 74 1 PGE PGE NNP cord-333368-kjrk8nn9 74 2 2 2 CD cord-333368-kjrk8nn9 74 3 signaling signal VBG cord-333368-kjrk8nn9 74 4 can can MD cord-333368-kjrk8nn9 74 5 impair impair VB cord-333368-kjrk8nn9 74 6 macrophage macrophage NN cord-333368-kjrk8nn9 74 7 innate innate JJ cord-333368-kjrk8nn9 74 8 immune immune JJ cord-333368-kjrk8nn9 74 9 functions function NNS cord-333368-kjrk8nn9 74 10 as as RB cord-333368-kjrk8nn9 74 11 well well RB cord-333368-kjrk8nn9 74 12 as as IN cord-333368-kjrk8nn9 74 13 alter alter NN cord-333368-kjrk8nn9 74 14 production production NN cord-333368-kjrk8nn9 74 15 of of IN cord-333368-kjrk8nn9 74 16 pro pro JJ cord-333368-kjrk8nn9 74 17 - - JJ cord-333368-kjrk8nn9 74 18 inflammatory inflammatory JJ cord-333368-kjrk8nn9 74 19 cytokines cytokine NNS cord-333368-kjrk8nn9 74 20 61 61 CD cord-333368-kjrk8nn9 74 21 . . . cord-333368-kjrk8nn9 75 1 This this DT cord-333368-kjrk8nn9 75 2 activated activate VBN cord-333368-kjrk8nn9 75 3 state state NN cord-333368-kjrk8nn9 75 4 causes cause NNS cord-333368-kjrk8nn9 75 5 delayed delay VBN cord-333368-kjrk8nn9 75 6 wound wound NN cord-333368-kjrk8nn9 75 7 healing healing NN cord-333368-kjrk8nn9 75 8 but but CC cord-333368-kjrk8nn9 75 9 may may MD cord-333368-kjrk8nn9 75 10 also also RB cord-333368-kjrk8nn9 75 11 have have VB cord-333368-kjrk8nn9 75 12 further further JJ cord-333368-kjrk8nn9 75 13 implications implication NNS cord-333368-kjrk8nn9 75 14 in in IN cord-333368-kjrk8nn9 75 15 responses response NNS cord-333368-kjrk8nn9 75 16 to to IN cord-333368-kjrk8nn9 75 17 infection infection NN cord-333368-kjrk8nn9 75 18 , , , cord-333368-kjrk8nn9 75 19 which which WDT cord-333368-kjrk8nn9 75 20 is be VBZ cord-333368-kjrk8nn9 75 21 a a DT cord-333368-kjrk8nn9 75 22 major major JJ cord-333368-kjrk8nn9 75 23 physiologic physiologic JJ cord-333368-kjrk8nn9 75 24 function function NN cord-333368-kjrk8nn9 75 25 of of IN cord-333368-kjrk8nn9 75 26 macrophages macrophage NNS cord-333368-kjrk8nn9 75 27 . . . cord-333368-kjrk8nn9 76 1 PGE PGE NNP cord-333368-kjrk8nn9 76 2 2 2 CD cord-333368-kjrk8nn9 76 3 signaling signal VBG cord-333368-kjrk8nn9 76 4 instructs instruct VBZ cord-333368-kjrk8nn9 76 5 macrophages macrophage NNS cord-333368-kjrk8nn9 76 6 to to TO cord-333368-kjrk8nn9 76 7 secrete secrete VB cord-333368-kjrk8nn9 76 8 IL-10 IL-10 NNP cord-333368-kjrk8nn9 76 9 and and CC cord-333368-kjrk8nn9 76 10 influences influence VBZ cord-333368-kjrk8nn9 76 11 naïve naïve JJ cord-333368-kjrk8nn9 76 12 T T NNP cord-333368-kjrk8nn9 76 13 cells cell NNS cord-333368-kjrk8nn9 76 14 to to TO cord-333368-kjrk8nn9 76 15 shift shift VB cord-333368-kjrk8nn9 76 16 from from IN cord-333368-kjrk8nn9 76 17 a a DT cord-333368-kjrk8nn9 76 18 Th1 th1 NN cord-333368-kjrk8nn9 76 19 to to IN cord-333368-kjrk8nn9 76 20 a a DT cord-333368-kjrk8nn9 76 21 Th2 th2 CD cord-333368-kjrk8nn9 76 22 phenotype phenotype NN cord-333368-kjrk8nn9 76 23 . . . cord-333368-kjrk8nn9 77 1 This this DT cord-333368-kjrk8nn9 77 2 Th2 th2 CD cord-333368-kjrk8nn9 77 3 phenotype phenotype NN cord-333368-kjrk8nn9 77 4 causes cause VBZ cord-333368-kjrk8nn9 77 5 a a DT cord-333368-kjrk8nn9 77 6 decreased decrease VBN cord-333368-kjrk8nn9 77 7 ability ability NN cord-333368-kjrk8nn9 77 8 to to TO cord-333368-kjrk8nn9 77 9 clear clear VB cord-333368-kjrk8nn9 77 10 intracellular intracellular JJ cord-333368-kjrk8nn9 77 11 pathogens pathogen NNS cord-333368-kjrk8nn9 77 12 , , , cord-333368-kjrk8nn9 77 13 such such JJ cord-333368-kjrk8nn9 77 14 as as IN cord-333368-kjrk8nn9 77 15 viruses virus NNS cord-333368-kjrk8nn9 77 16 62 62 CD cord-333368-kjrk8nn9 77 17 . . . cord-333368-kjrk8nn9 78 1 Immune immune JJ cord-333368-kjrk8nn9 78 2 system system NN cord-333368-kjrk8nn9 78 3 activation activation NN cord-333368-kjrk8nn9 78 4 in in IN cord-333368-kjrk8nn9 78 5 obesity obesity NN cord-333368-kjrk8nn9 78 6 is be VBZ cord-333368-kjrk8nn9 78 7 not not RB cord-333368-kjrk8nn9 78 8 confined confine VBN cord-333368-kjrk8nn9 78 9 to to IN cord-333368-kjrk8nn9 78 10 adipose adipose JJ cord-333368-kjrk8nn9 78 11 tissue tissue NN cord-333368-kjrk8nn9 78 12 or or CC cord-333368-kjrk8nn9 78 13 organ organ NN cord-333368-kjrk8nn9 78 14 dysfunction dysfunction NN cord-333368-kjrk8nn9 78 15 related relate VBN cord-333368-kjrk8nn9 78 16 to to IN cord-333368-kjrk8nn9 78 17 metabolic metabolic JJ cord-333368-kjrk8nn9 78 18 disease disease NN cord-333368-kjrk8nn9 78 19 , , , cord-333368-kjrk8nn9 78 20 such such JJ cord-333368-kjrk8nn9 78 21 as as IN cord-333368-kjrk8nn9 78 22 the the DT cord-333368-kjrk8nn9 78 23 liver liver NN cord-333368-kjrk8nn9 78 24 or or CC cord-333368-kjrk8nn9 78 25 vasculature vasculature NN cord-333368-kjrk8nn9 78 26 , , , cord-333368-kjrk8nn9 78 27 but but CC cord-333368-kjrk8nn9 78 28 also also RB cord-333368-kjrk8nn9 78 29 has have VBZ cord-333368-kjrk8nn9 78 30 a a DT cord-333368-kjrk8nn9 78 31 negative negative JJ cord-333368-kjrk8nn9 78 32 effect effect NN cord-333368-kjrk8nn9 78 33 on on IN cord-333368-kjrk8nn9 78 34 the the DT cord-333368-kjrk8nn9 78 35 immune immune JJ cord-333368-kjrk8nn9 78 36 system system NN cord-333368-kjrk8nn9 78 37 on on IN cord-333368-kjrk8nn9 78 38 the the DT cord-333368-kjrk8nn9 78 39 whole whole NN cord-333368-kjrk8nn9 78 40 , , , cord-333368-kjrk8nn9 78 41 leading lead VBG cord-333368-kjrk8nn9 78 42 to to IN cord-333368-kjrk8nn9 78 43 an an DT cord-333368-kjrk8nn9 78 44 increase increase NN cord-333368-kjrk8nn9 78 45 risk risk NN cord-333368-kjrk8nn9 78 46 of of IN cord-333368-kjrk8nn9 78 47 infection infection NN cord-333368-kjrk8nn9 78 48 63 63 CD cord-333368-kjrk8nn9 78 49 . . . cord-333368-kjrk8nn9 79 1 It -PRON- PRP cord-333368-kjrk8nn9 79 2 is be VBZ cord-333368-kjrk8nn9 79 3 well well RB cord-333368-kjrk8nn9 79 4 recognized recognize VBN cord-333368-kjrk8nn9 79 5 clinically clinically RB cord-333368-kjrk8nn9 79 6 that that IN cord-333368-kjrk8nn9 79 7 diabetes diabetes NN cord-333368-kjrk8nn9 79 8 negatively negatively RB cord-333368-kjrk8nn9 79 9 impacts impact VBZ cord-333368-kjrk8nn9 79 10 the the DT cord-333368-kjrk8nn9 79 11 body body NN cord-333368-kjrk8nn9 79 12 's 's POS cord-333368-kjrk8nn9 79 13 response response NN cord-333368-kjrk8nn9 79 14 to to IN cord-333368-kjrk8nn9 79 15 infection infection NN cord-333368-kjrk8nn9 79 16 . . . cord-333368-kjrk8nn9 80 1 Hyperglycemia hyperglycemia NN cord-333368-kjrk8nn9 80 2 stemming stem VBG cord-333368-kjrk8nn9 80 3 from from IN cord-333368-kjrk8nn9 80 4 T2D t2d DT cord-333368-kjrk8nn9 80 5 caused cause VBN cord-333368-kjrk8nn9 80 6 by by IN cord-333368-kjrk8nn9 80 7 obesity obesity NN cord-333368-kjrk8nn9 80 8 has have VBZ cord-333368-kjrk8nn9 80 9 proven prove VBN cord-333368-kjrk8nn9 80 10 to to TO cord-333368-kjrk8nn9 80 11 reduce reduce VB cord-333368-kjrk8nn9 80 12 control control NN cord-333368-kjrk8nn9 80 13 of of IN cord-333368-kjrk8nn9 80 14 invading invade VBG cord-333368-kjrk8nn9 80 15 pathogens pathogen NNS cord-333368-kjrk8nn9 80 16 64 64 CD cord-333368-kjrk8nn9 80 17 Even even RB cord-333368-kjrk8nn9 80 18 more more RBR cord-333368-kjrk8nn9 80 19 broadly broadly RB cord-333368-kjrk8nn9 80 20 in in IN cord-333368-kjrk8nn9 80 21 sepsis sepsis NN cord-333368-kjrk8nn9 80 22 models model NNS cord-333368-kjrk8nn9 80 23 , , , cord-333368-kjrk8nn9 80 24 obese obese JJ cord-333368-kjrk8nn9 80 25 animals animal NNS cord-333368-kjrk8nn9 80 26 have have VBP cord-333368-kjrk8nn9 80 27 been be VBN cord-333368-kjrk8nn9 80 28 seen see VBN cord-333368-kjrk8nn9 80 29 to to TO cord-333368-kjrk8nn9 80 30 have have VB cord-333368-kjrk8nn9 80 31 more more JJR cord-333368-kjrk8nn9 80 32 severe severe JJ cord-333368-kjrk8nn9 80 33 organ organ NN cord-333368-kjrk8nn9 80 34 damage damage NN cord-333368-kjrk8nn9 80 35 and and CC cord-333368-kjrk8nn9 80 36 worsened worsen VBD cord-333368-kjrk8nn9 80 37 survival survival NN cord-333368-kjrk8nn9 80 38 76,77 76,77 CD cord-333368-kjrk8nn9 80 39 . . . cord-333368-kjrk8nn9 81 1 A a DT cord-333368-kjrk8nn9 81 2 c c NN cord-333368-kjrk8nn9 81 3 c c NN cord-333368-kjrk8nn9 81 4 e e NN cord-333368-kjrk8nn9 81 5 p p NN cord-333368-kjrk8nn9 81 6 t t NN cord-333368-kjrk8nn9 81 7 e e NN cord-333368-kjrk8nn9 81 8 d d NNP cord-333368-kjrk8nn9 81 9 M M NNP cord-333368-kjrk8nn9 81 10 a a NNP cord-333368-kjrk8nn9 81 11 n n NN cord-333368-kjrk8nn9 81 12 u u NNP cord-333368-kjrk8nn9 81 13 s s NNP cord-333368-kjrk8nn9 81 14 c c NN cord-333368-kjrk8nn9 81 15 r r NN cord-333368-kjrk8nn9 81 16 i i NN cord-333368-kjrk8nn9 81 17 p p NN cord-333368-kjrk8nn9 81 18 t t NN cord-333368-kjrk8nn9 81 19 10 10 CD cord-333368-kjrk8nn9 82 1 Even even RB cord-333368-kjrk8nn9 82 2 a a DT cord-333368-kjrk8nn9 82 3 short short JJ cord-333368-kjrk8nn9 82 4 - - HYPH cord-333368-kjrk8nn9 82 5 term term NN cord-333368-kjrk8nn9 82 6 high high JJ cord-333368-kjrk8nn9 82 7 fat fat NN cord-333368-kjrk8nn9 82 8 diet diet NN cord-333368-kjrk8nn9 82 9 can can MD cord-333368-kjrk8nn9 82 10 impact impact VB cord-333368-kjrk8nn9 82 11 the the DT cord-333368-kjrk8nn9 82 12 reaction reaction NN cord-333368-kjrk8nn9 82 13 to to IN cord-333368-kjrk8nn9 82 14 a a DT cord-333368-kjrk8nn9 82 15 bacterial bacterial JJ cord-333368-kjrk8nn9 82 16 infection infection NN cord-333368-kjrk8nn9 82 17 . . . cord-333368-kjrk8nn9 83 1 Mice mouse NNS cord-333368-kjrk8nn9 83 2 fed feed VBD cord-333368-kjrk8nn9 83 3 a a DT cord-333368-kjrk8nn9 83 4 high high JJ cord-333368-kjrk8nn9 83 5 fat fat NN cord-333368-kjrk8nn9 83 6 diet diet NN cord-333368-kjrk8nn9 83 7 for for IN cord-333368-kjrk8nn9 83 8 16 16 CD cord-333368-kjrk8nn9 83 9 days day NNS cord-333368-kjrk8nn9 83 10 and and CC cord-333368-kjrk8nn9 83 11 then then RB cord-333368-kjrk8nn9 83 12 orally orally RB cord-333368-kjrk8nn9 83 13 challenged challenge VBD cord-333368-kjrk8nn9 83 14 with with IN cord-333368-kjrk8nn9 83 15 Listeria Listeria NNP cord-333368-kjrk8nn9 83 16 monocytogenes monocytogene NNS cord-333368-kjrk8nn9 83 17 had have VBD cord-333368-kjrk8nn9 83 18 reduced reduce VBN cord-333368-kjrk8nn9 83 19 inflammatory inflammatory JJ cord-333368-kjrk8nn9 83 20 responses response NNS cord-333368-kjrk8nn9 83 21 , , , cord-333368-kjrk8nn9 83 22 and and CC cord-333368-kjrk8nn9 83 23 as as IN cord-333368-kjrk8nn9 83 24 a a DT cord-333368-kjrk8nn9 83 25 result result NN cord-333368-kjrk8nn9 83 26 increased increase VBN cord-333368-kjrk8nn9 83 27 bacterial bacterial JJ cord-333368-kjrk8nn9 83 28 load load NN cord-333368-kjrk8nn9 83 29 and and CC cord-333368-kjrk8nn9 83 30 increased increase VBN cord-333368-kjrk8nn9 83 31 numbers number NNS cord-333368-kjrk8nn9 83 32 of of IN cord-333368-kjrk8nn9 83 33 goblet goblet NN cord-333368-kjrk8nn9 83 34 cells cell NNS cord-333368-kjrk8nn9 83 35 78 78 CD cord-333368-kjrk8nn9 83 36 . . . cord-333368-kjrk8nn9 84 1 Obese obese JJ cord-333368-kjrk8nn9 84 2 individuals individual NNS cord-333368-kjrk8nn9 84 3 are be VBP cord-333368-kjrk8nn9 84 4 not not RB cord-333368-kjrk8nn9 84 5 only only RB cord-333368-kjrk8nn9 84 6 susceptible susceptible JJ cord-333368-kjrk8nn9 84 7 to to IN cord-333368-kjrk8nn9 84 8 severe severe JJ cord-333368-kjrk8nn9 84 9 bacterial bacterial JJ cord-333368-kjrk8nn9 84 10 infections infection NNS cord-333368-kjrk8nn9 84 11 , , , cord-333368-kjrk8nn9 84 12 but but CC cord-333368-kjrk8nn9 84 13 also also RB cord-333368-kjrk8nn9 84 14 severe severe JJ cord-333368-kjrk8nn9 84 15 viral viral JJ cord-333368-kjrk8nn9 84 16 infections infection NNS cord-333368-kjrk8nn9 84 17 . . . cord-333368-kjrk8nn9 85 1 Obesity obesity NN cord-333368-kjrk8nn9 85 2 has have VBZ cord-333368-kjrk8nn9 85 3 been be VBN cord-333368-kjrk8nn9 85 4 shown show VBN cord-333368-kjrk8nn9 85 5 to to TO cord-333368-kjrk8nn9 85 6 be be VB cord-333368-kjrk8nn9 85 7 a a DT cord-333368-kjrk8nn9 85 8 risk risk NN cord-333368-kjrk8nn9 85 9 factor factor NN cord-333368-kjrk8nn9 85 10 for for IN cord-333368-kjrk8nn9 85 11 human human JJ cord-333368-kjrk8nn9 85 12 papilloma papilloma NN cord-333368-kjrk8nn9 85 13 virus virus NN cord-333368-kjrk8nn9 85 14 incident incident NN cord-333368-kjrk8nn9 85 15 infection infection NN cord-333368-kjrk8nn9 85 16 , , , cord-333368-kjrk8nn9 85 17 however however RB cord-333368-kjrk8nn9 85 18 obesity obesity NN cord-333368-kjrk8nn9 85 19 was be VBD cord-333368-kjrk8nn9 85 20 not not RB cord-333368-kjrk8nn9 85 21 associated associate VBN cord-333368-kjrk8nn9 85 22 with with IN cord-333368-kjrk8nn9 85 23 how how WRB cord-333368-kjrk8nn9 85 24 long long JJ cord-333368-kjrk8nn9 85 25 the the DT cord-333368-kjrk8nn9 85 26 infection infection NN cord-333368-kjrk8nn9 85 27 persisted persist VBD cord-333368-kjrk8nn9 85 28 79 79 CD cord-333368-kjrk8nn9 85 29 . . . cord-333368-kjrk8nn9 86 1 Additionally additionally RB cord-333368-kjrk8nn9 86 2 , , , cord-333368-kjrk8nn9 86 3 in in IN cord-333368-kjrk8nn9 86 4 the the DT cord-333368-kjrk8nn9 86 5 2009 2009 CD cord-333368-kjrk8nn9 86 6 H1N1 H1N1 NNP cord-333368-kjrk8nn9 86 7 Influenza Influenza NNP cord-333368-kjrk8nn9 86 8 pandemic pandemic NN cord-333368-kjrk8nn9 86 9 , , , cord-333368-kjrk8nn9 86 10 obesity obesity NN cord-333368-kjrk8nn9 86 11 was be VBD cord-333368-kjrk8nn9 86 12 a a DT cord-333368-kjrk8nn9 86 13 major major JJ cord-333368-kjrk8nn9 86 14 risk risk NN cord-333368-kjrk8nn9 86 15 factor factor NN cord-333368-kjrk8nn9 86 16 for for IN cord-333368-kjrk8nn9 86 17 severe severe JJ cord-333368-kjrk8nn9 86 18 infection infection NN cord-333368-kjrk8nn9 86 19 and and CC cord-333368-kjrk8nn9 86 20 death death NN cord-333368-kjrk8nn9 86 21 24 24 CD cord-333368-kjrk8nn9 86 22 . . . cord-333368-kjrk8nn9 87 1 Adults adult NNS cord-333368-kjrk8nn9 87 2 aged age VBN cord-333368-kjrk8nn9 87 3 20 20 CD cord-333368-kjrk8nn9 87 4 years year NNS cord-333368-kjrk8nn9 87 5 or or CC cord-333368-kjrk8nn9 87 6 older old JJR cord-333368-kjrk8nn9 87 7 who who WP cord-333368-kjrk8nn9 87 8 died die VBD cord-333368-kjrk8nn9 87 9 from from IN cord-333368-kjrk8nn9 87 10 H1N1 H1N1 NNP cord-333368-kjrk8nn9 87 11 infection infection NN cord-333368-kjrk8nn9 87 12 were be VBD cord-333368-kjrk8nn9 87 13 more more RBR cord-333368-kjrk8nn9 87 14 likely likely JJ cord-333368-kjrk8nn9 87 15 to to TO cord-333368-kjrk8nn9 87 16 be be VB cord-333368-kjrk8nn9 87 17 obese obese JJ cord-333368-kjrk8nn9 87 18 or or CC cord-333368-kjrk8nn9 87 19 morbidly morbidly RB cord-333368-kjrk8nn9 87 20 obese obese JJ cord-333368-kjrk8nn9 87 21 80 80 CD cord-333368-kjrk8nn9 87 22 . . . cord-333368-kjrk8nn9 88 1 When when WRB cord-333368-kjrk8nn9 88 2 lean lean JJ cord-333368-kjrk8nn9 88 3 and and CC cord-333368-kjrk8nn9 88 4 obese obese JJ cord-333368-kjrk8nn9 88 5 mice mouse NNS cord-333368-kjrk8nn9 88 6 are be VBP cord-333368-kjrk8nn9 88 7 infected infect VBN cord-333368-kjrk8nn9 88 8 with with IN cord-333368-kjrk8nn9 88 9 H1N1 H1N1 NNP cord-333368-kjrk8nn9 88 10 , , , cord-333368-kjrk8nn9 88 11 although although IN cord-333368-kjrk8nn9 88 12 the the DT cord-333368-kjrk8nn9 88 13 lungs lung NNS cord-333368-kjrk8nn9 88 14 exhibit exhibit VBP cord-333368-kjrk8nn9 88 15 the the DT cord-333368-kjrk8nn9 88 16 same same JJ cord-333368-kjrk8nn9 88 17 viral viral JJ cord-333368-kjrk8nn9 88 18 titer titer NN cord-333368-kjrk8nn9 88 19 , , , cord-333368-kjrk8nn9 88 20 the the DT cord-333368-kjrk8nn9 88 21 obese obese JJ cord-333368-kjrk8nn9 88 22 mice mouse NNS cord-333368-kjrk8nn9 88 23 lost lose VBD cord-333368-kjrk8nn9 88 24 more more JJR cord-333368-kjrk8nn9 88 25 weight weight NN cord-333368-kjrk8nn9 88 26 and and CC cord-333368-kjrk8nn9 88 27 experienced experience VBD cord-333368-kjrk8nn9 88 28 more more JJR cord-333368-kjrk8nn9 88 29 pulmonary pulmonary JJ cord-333368-kjrk8nn9 88 30 pathology pathology NN cord-333368-kjrk8nn9 88 31 than than IN cord-333368-kjrk8nn9 88 32 lean lean JJ cord-333368-kjrk8nn9 88 33 mice mouse NNS cord-333368-kjrk8nn9 88 34 . . . cord-333368-kjrk8nn9 89 1 Additionally additionally RB cord-333368-kjrk8nn9 89 2 , , , cord-333368-kjrk8nn9 89 3 the the DT cord-333368-kjrk8nn9 89 4 virus virus NN cord-333368-kjrk8nn9 89 5 spread spread VBD cord-333368-kjrk8nn9 89 6 to to IN cord-333368-kjrk8nn9 89 7 the the DT cord-333368-kjrk8nn9 89 8 alveolar alveolar JJ cord-333368-kjrk8nn9 89 9 epithelial epithelial JJ cord-333368-kjrk8nn9 89 10 cells cell NNS cord-333368-kjrk8nn9 89 11 in in IN cord-333368-kjrk8nn9 89 12 the the DT cord-333368-kjrk8nn9 89 13 obese obese JJ cord-333368-kjrk8nn9 89 14 mice mouse NNS cord-333368-kjrk8nn9 89 15 . . . cord-333368-kjrk8nn9 90 1 The the DT cord-333368-kjrk8nn9 90 2 increased increase VBN cord-333368-kjrk8nn9 90 3 spreading spreading NN cord-333368-kjrk8nn9 90 4 of of IN cord-333368-kjrk8nn9 90 5 the the DT cord-333368-kjrk8nn9 90 6 virus virus NN cord-333368-kjrk8nn9 90 7 in in IN cord-333368-kjrk8nn9 90 8 obese obese JJ cord-333368-kjrk8nn9 90 9 mice mouse NNS cord-333368-kjrk8nn9 90 10 combined combine VBN cord-333368-kjrk8nn9 90 11 with with IN cord-333368-kjrk8nn9 90 12 the the DT cord-333368-kjrk8nn9 90 13 reduction reduction NN cord-333368-kjrk8nn9 90 14 in in IN cord-333368-kjrk8nn9 90 15 local local JJ cord-333368-kjrk8nn9 90 16 production production NN cord-333368-kjrk8nn9 90 17 of of IN cord-333368-kjrk8nn9 90 18 several several JJ cord-333368-kjrk8nn9 90 19 pro pro JJ cord-333368-kjrk8nn9 90 20 - - JJ cord-333368-kjrk8nn9 90 21 inflammatory inflammatory JJ cord-333368-kjrk8nn9 90 22 cytokines cytokine NNS cord-333368-kjrk8nn9 90 23 ( ( -LRB- cord-333368-kjrk8nn9 90 24 while while IN cord-333368-kjrk8nn9 90 25 still still RB cord-333368-kjrk8nn9 90 26 increased increase VBD cord-333368-kjrk8nn9 90 27 in in IN cord-333368-kjrk8nn9 90 28 circulation circulation NN cord-333368-kjrk8nn9 90 29 ) ) -RRB- cord-333368-kjrk8nn9 90 30 likely likely RB cord-333368-kjrk8nn9 90 31 contributed contribute VBD cord-333368-kjrk8nn9 90 32 to to IN cord-333368-kjrk8nn9 90 33 the the DT cord-333368-kjrk8nn9 90 34 increased increase VBN cord-333368-kjrk8nn9 90 35 murine murine JJ cord-333368-kjrk8nn9 90 36 morbidity morbidity NN cord-333368-kjrk8nn9 90 37 and and CC cord-333368-kjrk8nn9 90 38 mortality mortality NN cord-333368-kjrk8nn9 90 39 due due IN cord-333368-kjrk8nn9 90 40 to to IN cord-333368-kjrk8nn9 90 41 infection infection NN cord-333368-kjrk8nn9 90 42 81 81 CD cord-333368-kjrk8nn9 90 43 . . . cord-333368-kjrk8nn9 91 1 The the DT cord-333368-kjrk8nn9 91 2 same same JJ cord-333368-kjrk8nn9 91 3 illness illness NN cord-333368-kjrk8nn9 91 4 severity severity NN cord-333368-kjrk8nn9 91 5 and and CC cord-333368-kjrk8nn9 91 6 poor poor JJ cord-333368-kjrk8nn9 91 7 responsiveness responsiveness NN cord-333368-kjrk8nn9 91 8 to to IN cord-333368-kjrk8nn9 91 9 treatment treatment NN cord-333368-kjrk8nn9 91 10 with with IN cord-333368-kjrk8nn9 91 11 obesity obesity NN cord-333368-kjrk8nn9 91 12 has have VBZ cord-333368-kjrk8nn9 91 13 been be VBN cord-333368-kjrk8nn9 91 14 demonstrated demonstrate VBN cord-333368-kjrk8nn9 91 15 in in IN cord-333368-kjrk8nn9 91 16 seasonal seasonal JJ cord-333368-kjrk8nn9 91 17 influenza influenza NN cord-333368-kjrk8nn9 91 18 infections infection NNS cord-333368-kjrk8nn9 91 19 82 82 CD cord-333368-kjrk8nn9 91 20 . . . cord-333368-kjrk8nn9 92 1 It -PRON- PRP cord-333368-kjrk8nn9 92 2 has have VBZ cord-333368-kjrk8nn9 92 3 been be VBN cord-333368-kjrk8nn9 92 4 widely widely RB cord-333368-kjrk8nn9 92 5 speculated speculate VBN cord-333368-kjrk8nn9 92 6 that that IN cord-333368-kjrk8nn9 92 7 higher high JJR cord-333368-kjrk8nn9 92 8 ACE-2 ACE-2 NNP cord-333368-kjrk8nn9 92 9 expression expression NN cord-333368-kjrk8nn9 92 10 in in IN cord-333368-kjrk8nn9 92 11 adipose adipose JJ cord-333368-kjrk8nn9 92 12 tissue tissue NN cord-333368-kjrk8nn9 92 13 may may MD cord-333368-kjrk8nn9 92 14 result result VB cord-333368-kjrk8nn9 92 15 in in IN cord-333368-kjrk8nn9 92 16 higher high JJR cord-333368-kjrk8nn9 92 17 total total JJ cord-333368-kjrk8nn9 92 18 body body NN cord-333368-kjrk8nn9 92 19 SARS SARS NNP cord-333368-kjrk8nn9 92 20 - - HYPH cord-333368-kjrk8nn9 92 21 CoV-2 CoV-2 NNP cord-333368-kjrk8nn9 92 22 viral viral JJ cord-333368-kjrk8nn9 92 23 load load NN cord-333368-kjrk8nn9 92 24 in in IN cord-333368-kjrk8nn9 92 25 obese obese JJ cord-333368-kjrk8nn9 92 26 individuals individual NNS cord-333368-kjrk8nn9 92 27 . . . cord-333368-kjrk8nn9 93 1 Early early JJ cord-333368-kjrk8nn9 93 2 reports report NNS cord-333368-kjrk8nn9 93 3 have have VBP cord-333368-kjrk8nn9 93 4 not not RB cord-333368-kjrk8nn9 93 5 demonstrated demonstrate VBN cord-333368-kjrk8nn9 93 6 a a DT cord-333368-kjrk8nn9 93 7 correlation correlation NN cord-333368-kjrk8nn9 93 8 among among IN cord-333368-kjrk8nn9 93 9 viral viral JJ cord-333368-kjrk8nn9 93 10 load load NN cord-333368-kjrk8nn9 93 11 and and CC cord-333368-kjrk8nn9 93 12 obesity obesity NN cord-333368-kjrk8nn9 93 13 or or CC cord-333368-kjrk8nn9 93 14 initial initial JJ cord-333368-kjrk8nn9 93 15 viral viral JJ cord-333368-kjrk8nn9 93 16 load load NN cord-333368-kjrk8nn9 93 17 and and CC cord-333368-kjrk8nn9 93 18 disease disease NN cord-333368-kjrk8nn9 93 19 severity severity NN cord-333368-kjrk8nn9 93 20 83 83 CD cord-333368-kjrk8nn9 93 21 . . . cord-333368-kjrk8nn9 94 1 In in IN cord-333368-kjrk8nn9 94 2 seasonal seasonal JJ cord-333368-kjrk8nn9 94 3 and and CC cord-333368-kjrk8nn9 94 4 pandemic pandemic NN cord-333368-kjrk8nn9 94 5 influenza influenza NN cord-333368-kjrk8nn9 94 6 , , , cord-333368-kjrk8nn9 94 7 however however RB cord-333368-kjrk8nn9 94 8 , , , cord-333368-kjrk8nn9 94 9 obese obese JJ cord-333368-kjrk8nn9 94 10 individuals individual NNS cord-333368-kjrk8nn9 94 11 may may MD cord-333368-kjrk8nn9 94 12 be be VB cord-333368-kjrk8nn9 94 13 more more RBR cord-333368-kjrk8nn9 94 14 susceptible susceptible JJ cord-333368-kjrk8nn9 94 15 to to IN cord-333368-kjrk8nn9 94 16 severe severe JJ cord-333368-kjrk8nn9 94 17 viral viral JJ cord-333368-kjrk8nn9 94 18 respiratory respiratory JJ cord-333368-kjrk8nn9 94 19 disease disease NN cord-333368-kjrk8nn9 94 20 even even RB cord-333368-kjrk8nn9 94 21 if if IN cord-333368-kjrk8nn9 94 22 they -PRON- PRP cord-333368-kjrk8nn9 94 23 mount mount VBP cord-333368-kjrk8nn9 94 24 a a DT cord-333368-kjrk8nn9 94 25 serologic serologic JJ cord-333368-kjrk8nn9 94 26 response response NN cord-333368-kjrk8nn9 94 27 to to IN cord-333368-kjrk8nn9 94 28 vaccination vaccination NN cord-333368-kjrk8nn9 95 1 25 25 CD cord-333368-kjrk8nn9 95 2 A a DT cord-333368-kjrk8nn9 96 1 c c NNP cord-333368-kjrk8nn9 96 2 c c NN cord-333368-kjrk8nn9 96 3 e e NN cord-333368-kjrk8nn9 96 4 p p NN cord-333368-kjrk8nn9 97 1 t t NNP cord-333368-kjrk8nn9 97 2 e e NNP cord-333368-kjrk8nn9 97 3 d d NNP cord-333368-kjrk8nn9 97 4 M M NNP cord-333368-kjrk8nn9 97 5 a a NNP cord-333368-kjrk8nn9 98 1 n n CC cord-333368-kjrk8nn9 98 2 u u NNP cord-333368-kjrk8nn9 98 3 s s NNP cord-333368-kjrk8nn9 98 4 c c NN cord-333368-kjrk8nn9 98 5 r r NN cord-333368-kjrk8nn9 98 6 i i PRP cord-333368-kjrk8nn9 99 1 p p NN cord-333368-kjrk8nn9 99 2 t t NN cord-333368-kjrk8nn9 99 3 11 11 CD cord-333368-kjrk8nn9 100 1 Along along IN cord-333368-kjrk8nn9 100 2 with with IN cord-333368-kjrk8nn9 100 3 possible possible JJ cord-333368-kjrk8nn9 100 4 impairments impairment NNS cord-333368-kjrk8nn9 100 5 in in IN cord-333368-kjrk8nn9 100 6 pathogen pathogen NN cord-333368-kjrk8nn9 100 7 clearance clearance NN cord-333368-kjrk8nn9 100 8 , , , cord-333368-kjrk8nn9 100 9 obese obese JJ cord-333368-kjrk8nn9 100 10 hosts host NNS cord-333368-kjrk8nn9 100 11 are be VBP cord-333368-kjrk8nn9 100 12 more more RBR cord-333368-kjrk8nn9 100 13 likely likely JJ cord-333368-kjrk8nn9 100 14 to to TO cord-333368-kjrk8nn9 100 15 experience experience VB cord-333368-kjrk8nn9 100 16 the the DT cord-333368-kjrk8nn9 100 17 breakdown breakdown NN cord-333368-kjrk8nn9 100 18 of of IN cord-333368-kjrk8nn9 100 19 respiratory respiratory JJ cord-333368-kjrk8nn9 100 20 epithelium epithelium NN cord-333368-kjrk8nn9 100 21 during during IN cord-333368-kjrk8nn9 100 22 a a DT cord-333368-kjrk8nn9 100 23 pulmonary pulmonary JJ cord-333368-kjrk8nn9 100 24 infection infection NN cord-333368-kjrk8nn9 100 25 , , , cord-333368-kjrk8nn9 100 26 which which WDT cord-333368-kjrk8nn9 100 27 leads lead VBZ cord-333368-kjrk8nn9 100 28 to to IN cord-333368-kjrk8nn9 100 29 increased increase VBN cord-333368-kjrk8nn9 100 30 fluid fluid NN cord-333368-kjrk8nn9 100 31 in in IN cord-333368-kjrk8nn9 100 32 the the DT cord-333368-kjrk8nn9 100 33 airway airway NN cord-333368-kjrk8nn9 100 34 space space NN cord-333368-kjrk8nn9 100 35 . . . cord-333368-kjrk8nn9 101 1 This this DT cord-333368-kjrk8nn9 101 2 allows allow VBZ cord-333368-kjrk8nn9 101 3 the the DT cord-333368-kjrk8nn9 101 4 pathogen pathogen NN cord-333368-kjrk8nn9 101 5 to to TO cord-333368-kjrk8nn9 101 6 have have VB cord-333368-kjrk8nn9 101 7 the the DT cord-333368-kjrk8nn9 101 8 opportunity opportunity NN cord-333368-kjrk8nn9 101 9 to to TO cord-333368-kjrk8nn9 101 10 more more RBR cord-333368-kjrk8nn9 101 11 easily easily RB cord-333368-kjrk8nn9 101 12 spread spread VBN cord-333368-kjrk8nn9 101 13 throughout throughout IN cord-333368-kjrk8nn9 101 14 the the DT cord-333368-kjrk8nn9 101 15 body body NN cord-333368-kjrk8nn9 101 16 and and CC cord-333368-kjrk8nn9 101 17 leaves leave VBZ cord-333368-kjrk8nn9 101 18 the the DT cord-333368-kjrk8nn9 101 19 host host NN cord-333368-kjrk8nn9 101 20 with with IN cord-333368-kjrk8nn9 101 21 reduced reduce VBN cord-333368-kjrk8nn9 101 22 lung lung NN cord-333368-kjrk8nn9 101 23 function function NN cord-333368-kjrk8nn9 101 24 63 63 CD cord-333368-kjrk8nn9 101 25 . . . cord-333368-kjrk8nn9 102 1 The the DT cord-333368-kjrk8nn9 102 2 SARS SARS NNP cord-333368-kjrk8nn9 102 3 - - HYPH cord-333368-kjrk8nn9 102 4 CoV-2 CoV-2 NNP cord-333368-kjrk8nn9 102 5 virus virus NN cord-333368-kjrk8nn9 102 6 , , , cord-333368-kjrk8nn9 102 7 like like IN cord-333368-kjrk8nn9 102 8 other other JJ cord-333368-kjrk8nn9 102 9 members member NNS cord-333368-kjrk8nn9 102 10 of of IN cord-333368-kjrk8nn9 102 11 the the DT cord-333368-kjrk8nn9 102 12 betacoronavirus betacoronavirus NNP cord-333368-kjrk8nn9 102 13 subfamily subfamily NNP cord-333368-kjrk8nn9 102 14 85 85 CD cord-333368-kjrk8nn9 102 15 , , , cord-333368-kjrk8nn9 102 16 enters enter VBZ cord-333368-kjrk8nn9 102 17 mammalian mammalian JJ cord-333368-kjrk8nn9 102 18 cells cell NNS cord-333368-kjrk8nn9 102 19 through through IN cord-333368-kjrk8nn9 102 20 the the DT cord-333368-kjrk8nn9 102 21 interaction interaction NN cord-333368-kjrk8nn9 102 22 of of IN cord-333368-kjrk8nn9 102 23 the the DT cord-333368-kjrk8nn9 102 24 viral viral JJ cord-333368-kjrk8nn9 102 25 envelope envelope NN cord-333368-kjrk8nn9 102 26 spike spike NN cord-333368-kjrk8nn9 102 27 glycoprotein glycoprotein NN cord-333368-kjrk8nn9 102 28 and and CC cord-333368-kjrk8nn9 102 29 angiotensin angiotensin NN cord-333368-kjrk8nn9 102 30 converting convert VBG cord-333368-kjrk8nn9 102 31 enzyme enzyme NN cord-333368-kjrk8nn9 102 32 2 2 CD cord-333368-kjrk8nn9 102 33 ( ( -LRB- cord-333368-kjrk8nn9 102 34 ACE-2 ACE-2 NNP cord-333368-kjrk8nn9 102 35 ) ) -RRB- cord-333368-kjrk8nn9 102 36 on on IN cord-333368-kjrk8nn9 102 37 host host NN cord-333368-kjrk8nn9 102 38 cells cell NNS cord-333368-kjrk8nn9 102 39 86 86 CD cord-333368-kjrk8nn9 102 40 . . . cord-333368-kjrk8nn9 103 1 ACE-2 ACE-2 NNP cord-333368-kjrk8nn9 103 2 is be VBZ cord-333368-kjrk8nn9 103 3 expressed express VBN cord-333368-kjrk8nn9 103 4 in in IN cord-333368-kjrk8nn9 103 5 many many JJ cord-333368-kjrk8nn9 103 6 human human JJ cord-333368-kjrk8nn9 103 7 tissues tissue NNS cord-333368-kjrk8nn9 103 8 , , , cord-333368-kjrk8nn9 103 9 including include VBG cord-333368-kjrk8nn9 103 10 not not RB cord-333368-kjrk8nn9 103 11 only only RB cord-333368-kjrk8nn9 103 12 the the DT cord-333368-kjrk8nn9 103 13 lungs lung NNS cord-333368-kjrk8nn9 103 14 but but CC cord-333368-kjrk8nn9 103 15 also also RB cord-333368-kjrk8nn9 103 16 kidney kidney NN cord-333368-kjrk8nn9 103 17 , , , cord-333368-kjrk8nn9 103 18 brain brain NN cord-333368-kjrk8nn9 103 19 , , , cord-333368-kjrk8nn9 103 20 adipose adipose JJ cord-333368-kjrk8nn9 103 21 tissue tissue NN cord-333368-kjrk8nn9 103 22 and and CC cord-333368-kjrk8nn9 103 23 small small JJ cord-333368-kjrk8nn9 103 24 intestine intestine NN cord-333368-kjrk8nn9 103 25 , , , cord-333368-kjrk8nn9 103 26 raising raise VBG cord-333368-kjrk8nn9 103 27 the the DT cord-333368-kjrk8nn9 103 28 question question NN cord-333368-kjrk8nn9 103 29 of of IN cord-333368-kjrk8nn9 103 30 which which WDT cord-333368-kjrk8nn9 103 31 symptoms symptom NNS cord-333368-kjrk8nn9 103 32 of of IN cord-333368-kjrk8nn9 103 33 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 103 34 are be VBP cord-333368-kjrk8nn9 103 35 due due JJ cord-333368-kjrk8nn9 103 36 to to IN cord-333368-kjrk8nn9 103 37 direct direct JJ cord-333368-kjrk8nn9 103 38 viral viral JJ cord-333368-kjrk8nn9 103 39 effects effect NNS cord-333368-kjrk8nn9 103 40 versus versus IN cord-333368-kjrk8nn9 103 41 systemic systemic JJ cord-333368-kjrk8nn9 103 42 immune immune JJ cord-333368-kjrk8nn9 103 43 responses response NNS cord-333368-kjrk8nn9 103 44 , , , cord-333368-kjrk8nn9 103 45 especially especially RB cord-333368-kjrk8nn9 103 46 in in IN cord-333368-kjrk8nn9 103 47 severe severe JJ cord-333368-kjrk8nn9 103 48 disease disease NN cord-333368-kjrk8nn9 103 49 87 87 CD cord-333368-kjrk8nn9 103 50 . . . cord-333368-kjrk8nn9 104 1 Tropism tropism NN cord-333368-kjrk8nn9 104 2 of of IN cord-333368-kjrk8nn9 104 3 SARS SARS NNP cord-333368-kjrk8nn9 104 4 - - HYPH cord-333368-kjrk8nn9 104 5 CoV-2 CoV-2 NNP cord-333368-kjrk8nn9 104 6 for for IN cord-333368-kjrk8nn9 104 7 extrapulmonary extrapulmonary JJ cord-333368-kjrk8nn9 104 8 tissues tissue NNS cord-333368-kjrk8nn9 104 9 is be VBZ cord-333368-kjrk8nn9 104 10 confirmed confirm VBN cord-333368-kjrk8nn9 104 11 by by IN cord-333368-kjrk8nn9 104 12 detection detection NN cord-333368-kjrk8nn9 104 13 of of IN cord-333368-kjrk8nn9 104 14 viral viral JJ cord-333368-kjrk8nn9 104 15 RNA RNA NNP cord-333368-kjrk8nn9 104 16 from from IN cord-333368-kjrk8nn9 104 17 samples sample NNS cord-333368-kjrk8nn9 104 18 outside outside IN cord-333368-kjrk8nn9 104 19 the the DT cord-333368-kjrk8nn9 104 20 respiratory respiratory JJ cord-333368-kjrk8nn9 104 21 tract tract NN cord-333368-kjrk8nn9 104 22 88 88 CD cord-333368-kjrk8nn9 104 23 . . . cord-333368-kjrk8nn9 105 1 ACE-2 ACE-2 NNP cord-333368-kjrk8nn9 105 2 is be VBZ cord-333368-kjrk8nn9 105 3 upregulated upregulate VBN cord-333368-kjrk8nn9 105 4 in in IN cord-333368-kjrk8nn9 105 5 adipocytes adipocyte NNS cord-333368-kjrk8nn9 105 6 in in IN cord-333368-kjrk8nn9 105 7 obese obese JJ cord-333368-kjrk8nn9 105 8 and and CC cord-333368-kjrk8nn9 105 9 diabetic diabetic JJ cord-333368-kjrk8nn9 105 10 patients patient NNS cord-333368-kjrk8nn9 105 11 , , , cord-333368-kjrk8nn9 105 12 which which WDT cord-333368-kjrk8nn9 105 13 allows allow VBZ cord-333368-kjrk8nn9 105 14 the the DT cord-333368-kjrk8nn9 105 15 virus virus NN cord-333368-kjrk8nn9 105 16 to to TO cord-333368-kjrk8nn9 105 17 target target VB cord-333368-kjrk8nn9 105 18 and and CC cord-333368-kjrk8nn9 105 19 replicate replicate VB cord-333368-kjrk8nn9 105 20 in in IN cord-333368-kjrk8nn9 105 21 adipose adipose JJ cord-333368-kjrk8nn9 105 22 tissue tissue NN cord-333368-kjrk8nn9 105 23 and and CC cord-333368-kjrk8nn9 105 24 has have VBZ cord-333368-kjrk8nn9 105 25 led lead VBN cord-333368-kjrk8nn9 105 26 to to IN cord-333368-kjrk8nn9 105 27 speculation speculation NN cord-333368-kjrk8nn9 105 28 that that IN cord-333368-kjrk8nn9 105 29 adipose adipose JJ cord-333368-kjrk8nn9 105 30 tissue tissue NN cord-333368-kjrk8nn9 105 31 can can MD cord-333368-kjrk8nn9 105 32 serve serve VB cord-333368-kjrk8nn9 105 33 as as IN cord-333368-kjrk8nn9 105 34 a a DT cord-333368-kjrk8nn9 105 35 reservoir reservoir NN cord-333368-kjrk8nn9 105 36 of of IN cord-333368-kjrk8nn9 105 37 SARS SARS NNP cord-333368-kjrk8nn9 105 38 - - HYPH cord-333368-kjrk8nn9 105 39 CoV-2 CoV-2 NNP cord-333368-kjrk8nn9 105 40 , , , cord-333368-kjrk8nn9 105 41 potentially potentially RB cord-333368-kjrk8nn9 105 42 worsening worsen VBG cord-333368-kjrk8nn9 105 43 disease disease NN cord-333368-kjrk8nn9 105 44 severity severity NN cord-333368-kjrk8nn9 105 45 in in IN cord-333368-kjrk8nn9 105 46 obese obese JJ cord-333368-kjrk8nn9 105 47 individuals individual NNS cord-333368-kjrk8nn9 105 48 [ [ -LRB- cord-333368-kjrk8nn9 105 49 89 89 CD cord-333368-kjrk8nn9 105 50 ] ] -RRB- cord-333368-kjrk8nn9 105 51 [ [ -LRB- cord-333368-kjrk8nn9 105 52 90 90 CD cord-333368-kjrk8nn9 105 53 ] ] -RRB- cord-333368-kjrk8nn9 105 54 [ [ -LRB- cord-333368-kjrk8nn9 105 55 91 91 CD cord-333368-kjrk8nn9 105 56 ] ] -RRB- cord-333368-kjrk8nn9 105 57 . . . cord-333368-kjrk8nn9 106 1 A a DT cord-333368-kjrk8nn9 106 2 correlation correlation NN cord-333368-kjrk8nn9 106 3 between between IN cord-333368-kjrk8nn9 106 4 respiratory respiratory JJ cord-333368-kjrk8nn9 106 5 tract tract NN cord-333368-kjrk8nn9 106 6 viral viral JJ cord-333368-kjrk8nn9 106 7 load load NN cord-333368-kjrk8nn9 106 8 and and CC cord-333368-kjrk8nn9 106 9 obesity obesity NN cord-333368-kjrk8nn9 106 10 , , , cord-333368-kjrk8nn9 106 11 however however RB cord-333368-kjrk8nn9 106 12 , , , cord-333368-kjrk8nn9 106 13 has have VBZ cord-333368-kjrk8nn9 106 14 not not RB cord-333368-kjrk8nn9 106 15 been be VBN cord-333368-kjrk8nn9 106 16 confirmed confirm VBN cord-333368-kjrk8nn9 106 17 83 83 CD cord-333368-kjrk8nn9 106 18 . . . cord-333368-kjrk8nn9 107 1 Intestinal intestinal JJ cord-333368-kjrk8nn9 107 2 involvement involvement NN cord-333368-kjrk8nn9 107 3 in in IN cord-333368-kjrk8nn9 107 4 SARS SARS NNP cord-333368-kjrk8nn9 107 5 - - HYPH cord-333368-kjrk8nn9 107 6 CoV-2 CoV-2 NNP cord-333368-kjrk8nn9 107 7 infection infection NN cord-333368-kjrk8nn9 107 8 may may MD cord-333368-kjrk8nn9 107 9 interact interact VB cord-333368-kjrk8nn9 107 10 with with IN cord-333368-kjrk8nn9 107 11 obesity obesity NN cord-333368-kjrk8nn9 107 12 associated associate VBN cord-333368-kjrk8nn9 107 13 metainflammation metainflammation NN cord-333368-kjrk8nn9 107 14 . . . cord-333368-kjrk8nn9 108 1 While while IN cord-333368-kjrk8nn9 108 2 meta meta JJ cord-333368-kjrk8nn9 108 3 - - HYPH cord-333368-kjrk8nn9 108 4 inflammation inflammation NN cord-333368-kjrk8nn9 108 5 in in IN cord-333368-kjrk8nn9 108 6 obesity obesity NN cord-333368-kjrk8nn9 108 7 is be VBZ cord-333368-kjrk8nn9 108 8 a a DT cord-333368-kjrk8nn9 108 9 systemic systemic JJ cord-333368-kjrk8nn9 108 10 , , , cord-333368-kjrk8nn9 108 11 multifactorial multifactorial JJ cord-333368-kjrk8nn9 108 12 process process NN cord-333368-kjrk8nn9 108 13 92 92 CD cord-333368-kjrk8nn9 108 14 , , , cord-333368-kjrk8nn9 108 15 the the DT cord-333368-kjrk8nn9 108 16 gut gut NN cord-333368-kjrk8nn9 108 17 microbiome microbiome NN cord-333368-kjrk8nn9 108 18 is be VBZ cord-333368-kjrk8nn9 108 19 known know VBN cord-333368-kjrk8nn9 108 20 to to TO cord-333368-kjrk8nn9 108 21 have have VB cord-333368-kjrk8nn9 108 22 a a DT cord-333368-kjrk8nn9 108 23 bidirectional bidirectional JJ cord-333368-kjrk8nn9 108 24 relationship relationship NN cord-333368-kjrk8nn9 108 25 to to IN cord-333368-kjrk8nn9 108 26 meta meta JJ cord-333368-kjrk8nn9 108 27 - - HYPH cord-333368-kjrk8nn9 108 28 inflammation inflammation NN cord-333368-kjrk8nn9 108 29 93 93 CD cord-333368-kjrk8nn9 108 30 influencing influence VBG cord-333368-kjrk8nn9 108 31 intestinal intestinal JJ cord-333368-kjrk8nn9 108 32 inflammation inflammation NN cord-333368-kjrk8nn9 108 33 94 94 CD cord-333368-kjrk8nn9 108 34 . . . cord-333368-kjrk8nn9 109 1 SARS SARS NNP cord-333368-kjrk8nn9 109 2 - - HYPH cord-333368-kjrk8nn9 109 3 CoV-2 CoV-2 NNP cord-333368-kjrk8nn9 109 4 infection infection NN cord-333368-kjrk8nn9 109 5 has have VBZ cord-333368-kjrk8nn9 109 6 been be VBN cord-333368-kjrk8nn9 109 7 associated associate VBN cord-333368-kjrk8nn9 109 8 with with IN cord-333368-kjrk8nn9 109 9 shifts shift NNS cord-333368-kjrk8nn9 109 10 in in IN cord-333368-kjrk8nn9 109 11 gut gut NN cord-333368-kjrk8nn9 109 12 microbiota microbiota NN cord-333368-kjrk8nn9 109 13 to to IN cord-333368-kjrk8nn9 109 14 more more RBR cord-333368-kjrk8nn9 109 15 pathogenic pathogenic JJ cord-333368-kjrk8nn9 109 16 taxa taxon NNS cord-333368-kjrk8nn9 109 17 , , , cord-333368-kjrk8nn9 109 18 as as IN cord-333368-kjrk8nn9 109 19 have have VBP cord-333368-kjrk8nn9 109 20 other other JJ cord-333368-kjrk8nn9 109 21 states state NNS cord-333368-kjrk8nn9 109 22 of of IN cord-333368-kjrk8nn9 109 23 critical critical JJ cord-333368-kjrk8nn9 109 24 illness illness NN cord-333368-kjrk8nn9 109 25 95 95 CD cord-333368-kjrk8nn9 109 26 . . . cord-333368-kjrk8nn9 110 1 These these DT cord-333368-kjrk8nn9 110 2 shifts shift NNS cord-333368-kjrk8nn9 110 3 may may MD cord-333368-kjrk8nn9 110 4 encourage encourage VB cord-333368-kjrk8nn9 110 5 a a DT cord-333368-kjrk8nn9 110 6 state state NN cord-333368-kjrk8nn9 110 7 of of IN cord-333368-kjrk8nn9 110 8 A a DT cord-333368-kjrk8nn9 110 9 c c NN cord-333368-kjrk8nn9 110 10 c c NN cord-333368-kjrk8nn9 110 11 e e NN cord-333368-kjrk8nn9 110 12 p p NN cord-333368-kjrk8nn9 110 13 t t NN cord-333368-kjrk8nn9 110 14 e e NN cord-333368-kjrk8nn9 110 15 d d NNP cord-333368-kjrk8nn9 110 16 M M NNP cord-333368-kjrk8nn9 110 17 a a NNP cord-333368-kjrk8nn9 111 1 n n CC cord-333368-kjrk8nn9 111 2 u u NNP cord-333368-kjrk8nn9 111 3 s s NNP cord-333368-kjrk8nn9 111 4 c c NN cord-333368-kjrk8nn9 111 5 r r NN cord-333368-kjrk8nn9 111 6 i i NN cord-333368-kjrk8nn9 111 7 p p NN cord-333368-kjrk8nn9 111 8 t t NN cord-333368-kjrk8nn9 111 9 12 12 CD cord-333368-kjrk8nn9 111 10 systemic systemic JJ cord-333368-kjrk8nn9 111 11 inflammation inflammation NN cord-333368-kjrk8nn9 111 12 . . . cord-333368-kjrk8nn9 112 1 Both both DT cord-333368-kjrk8nn9 112 2 dysbiosis dysbiosis NN cord-333368-kjrk8nn9 112 3 and and CC cord-333368-kjrk8nn9 112 4 the the DT cord-333368-kjrk8nn9 112 5 direct direct JJ cord-333368-kjrk8nn9 112 6 enteropathic enteropathic JJ cord-333368-kjrk8nn9 112 7 effect effect NN cord-333368-kjrk8nn9 112 8 of of IN cord-333368-kjrk8nn9 112 9 SARS SARS NNP cord-333368-kjrk8nn9 112 10 - - HYPH cord-333368-kjrk8nn9 112 11 CoV-2 CoV-2 NNP cord-333368-kjrk8nn9 112 12 infection infection NN cord-333368-kjrk8nn9 112 13 may may MD cord-333368-kjrk8nn9 112 14 promote promote VB cord-333368-kjrk8nn9 112 15 gut gut NN cord-333368-kjrk8nn9 112 16 barrier barrier NN cord-333368-kjrk8nn9 112 17 permeability permeability NN cord-333368-kjrk8nn9 112 18 and and CC cord-333368-kjrk8nn9 112 19 increase increase VB cord-333368-kjrk8nn9 112 20 metabolic metabolic JJ cord-333368-kjrk8nn9 112 21 endotoxemia endotoxemia NN cord-333368-kjrk8nn9 112 22 , , , cord-333368-kjrk8nn9 112 23 a a DT cord-333368-kjrk8nn9 112 24 potential potential JJ cord-333368-kjrk8nn9 112 25 mediator mediator NN cord-333368-kjrk8nn9 112 26 of of IN cord-333368-kjrk8nn9 112 27 metabolic metabolic JJ cord-333368-kjrk8nn9 112 28 disease disease NN cord-333368-kjrk8nn9 112 29 and and CC cord-333368-kjrk8nn9 112 30 meta meta JJ cord-333368-kjrk8nn9 112 31 - - HYPH cord-333368-kjrk8nn9 112 32 inflammation inflammation NN cord-333368-kjrk8nn9 112 33 in in IN cord-333368-kjrk8nn9 112 34 obesity obesity NN cord-333368-kjrk8nn9 112 35 96 96 CD cord-333368-kjrk8nn9 112 36 . . . cord-333368-kjrk8nn9 113 1 Establishing establish VBG cord-333368-kjrk8nn9 113 2 a a DT cord-333368-kjrk8nn9 113 3 connection connection NN cord-333368-kjrk8nn9 113 4 between between IN cord-333368-kjrk8nn9 113 5 gut gut NN cord-333368-kjrk8nn9 113 6 dysfunction dysfunction NN cord-333368-kjrk8nn9 113 7 and and CC cord-333368-kjrk8nn9 113 8 meta meta JJ cord-333368-kjrk8nn9 113 9 - - HYPH cord-333368-kjrk8nn9 113 10 inflammation inflammation NN cord-333368-kjrk8nn9 113 11 in in IN cord-333368-kjrk8nn9 113 12 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 113 13 survivors survivor NNS cord-333368-kjrk8nn9 113 14 will will MD cord-333368-kjrk8nn9 113 15 require require VB cord-333368-kjrk8nn9 113 16 long long JJ cord-333368-kjrk8nn9 113 17 - - HYPH cord-333368-kjrk8nn9 113 18 term term NN cord-333368-kjrk8nn9 113 19 studies study NNS cord-333368-kjrk8nn9 113 20 . . . cord-333368-kjrk8nn9 114 1 While while IN cord-333368-kjrk8nn9 114 2 considerable considerable JJ cord-333368-kjrk8nn9 114 3 speculation speculation NN cord-333368-kjrk8nn9 114 4 has have VBZ cord-333368-kjrk8nn9 114 5 focused focus VBN cord-333368-kjrk8nn9 114 6 on on IN cord-333368-kjrk8nn9 114 7 how how WRB cord-333368-kjrk8nn9 114 8 ACE-2 ACE-2 NNP cord-333368-kjrk8nn9 114 9 levels level NNS cord-333368-kjrk8nn9 114 10 are be VBP cord-333368-kjrk8nn9 114 11 driven drive VBN cord-333368-kjrk8nn9 114 12 by by IN cord-333368-kjrk8nn9 114 13 either either DT cord-333368-kjrk8nn9 114 14 polymorphisms polymorphism NNS cord-333368-kjrk8nn9 114 15 , , , cord-333368-kjrk8nn9 114 16 comorbidity comorbidity NN cord-333368-kjrk8nn9 114 17 , , , cord-333368-kjrk8nn9 114 18 or or CC cord-333368-kjrk8nn9 114 19 environmental environmental JJ cord-333368-kjrk8nn9 114 20 factors factor NNS cord-333368-kjrk8nn9 114 21 , , , cord-333368-kjrk8nn9 114 22 other other JJ cord-333368-kjrk8nn9 114 23 genetic genetic JJ cord-333368-kjrk8nn9 114 24 factors factor NNS cord-333368-kjrk8nn9 114 25 may may MD cord-333368-kjrk8nn9 114 26 also also RB cord-333368-kjrk8nn9 114 27 play play VB cord-333368-kjrk8nn9 114 28 a a DT cord-333368-kjrk8nn9 114 29 role role NN cord-333368-kjrk8nn9 114 30 in in IN cord-333368-kjrk8nn9 114 31 susceptibility susceptibility NN cord-333368-kjrk8nn9 114 32 to to IN cord-333368-kjrk8nn9 114 33 severe severe JJ cord-333368-kjrk8nn9 114 34 COVID-19 covid-19 JJ cord-333368-kjrk8nn9 114 35 disease disease NN cord-333368-kjrk8nn9 114 36 , , , cord-333368-kjrk8nn9 114 37 as as RB cord-333368-kjrk8nn9 114 38 well well RB cord-333368-kjrk8nn9 114 39 97 97 CD cord-333368-kjrk8nn9 114 40 . . . cord-333368-kjrk8nn9 115 1 The the DT cord-333368-kjrk8nn9 115 2 first first JJ cord-333368-kjrk8nn9 115 3 genome genome NN cord-333368-kjrk8nn9 115 4 - - HYPH cord-333368-kjrk8nn9 115 5 wide wide JJ cord-333368-kjrk8nn9 115 6 association association NN cord-333368-kjrk8nn9 115 7 study study NN cord-333368-kjrk8nn9 115 8 of of IN cord-333368-kjrk8nn9 115 9 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 115 10 severity severity NN cord-333368-kjrk8nn9 115 11 identified identify VBD cord-333368-kjrk8nn9 115 12 two two CD cord-333368-kjrk8nn9 115 13 loci locus NNS cord-333368-kjrk8nn9 115 14 -one -one XX cord-333368-kjrk8nn9 115 15 containing contain VBG cord-333368-kjrk8nn9 115 16 the the DT cord-333368-kjrk8nn9 115 17 ABO ABO NNP cord-333368-kjrk8nn9 115 18 blood blood NN cord-333368-kjrk8nn9 115 19 group group NN cord-333368-kjrk8nn9 115 20 locus locus NN cord-333368-kjrk8nn9 115 21 and and CC cord-333368-kjrk8nn9 115 22 another another DT cord-333368-kjrk8nn9 115 23 at at IN cord-333368-kjrk8nn9 115 24 3p21.31 3p21.31 NN cord-333368-kjrk8nn9 115 25 98 98 CD cord-333368-kjrk8nn9 115 26 . . . cord-333368-kjrk8nn9 116 1 The the DT cord-333368-kjrk8nn9 116 2 latter latter JJ cord-333368-kjrk8nn9 116 3 locus locus NN cord-333368-kjrk8nn9 116 4 contains contain VBZ cord-333368-kjrk8nn9 116 5 several several JJ cord-333368-kjrk8nn9 116 6 chemokine chemokine NN cord-333368-kjrk8nn9 116 7 genes gene NNS cord-333368-kjrk8nn9 116 8 , , , cord-333368-kjrk8nn9 116 9 the the DT cord-333368-kjrk8nn9 116 10 expression expression NN cord-333368-kjrk8nn9 116 11 of of IN cord-333368-kjrk8nn9 116 12 which which WDT cord-333368-kjrk8nn9 116 13 may may MD cord-333368-kjrk8nn9 116 14 plausibly plausibly RB cord-333368-kjrk8nn9 116 15 be be VB cord-333368-kjrk8nn9 116 16 altered alter VBN cord-333368-kjrk8nn9 116 17 in in IN cord-333368-kjrk8nn9 116 18 meta meta JJ cord-333368-kjrk8nn9 116 19 - - HYPH cord-333368-kjrk8nn9 116 20 inflammation inflammation NN cord-333368-kjrk8nn9 116 21 . . . cord-333368-kjrk8nn9 117 1 An an DT cord-333368-kjrk8nn9 117 2 ongoing ongoing JJ cord-333368-kjrk8nn9 117 3 multinational multinational JJ cord-333368-kjrk8nn9 117 4 effort effort NN cord-333368-kjrk8nn9 117 5 continues continue VBZ cord-333368-kjrk8nn9 117 6 to to TO cord-333368-kjrk8nn9 117 7 examine examine VB cord-333368-kjrk8nn9 117 8 how how WRB cord-333368-kjrk8nn9 117 9 host host NN cord-333368-kjrk8nn9 117 10 genetics genetic NNS cord-333368-kjrk8nn9 117 11 may may MD cord-333368-kjrk8nn9 117 12 inform inform VB cord-333368-kjrk8nn9 117 13 susceptibility susceptibility NN cord-333368-kjrk8nn9 117 14 to to IN cord-333368-kjrk8nn9 117 15 severe severe JJ cord-333368-kjrk8nn9 117 16 COVID19 covid19 NN cord-333368-kjrk8nn9 117 17 and and CC cord-333368-kjrk8nn9 117 18 may may MD cord-333368-kjrk8nn9 117 19 reveal reveal VB cord-333368-kjrk8nn9 117 20 factors factor NNS cord-333368-kjrk8nn9 117 21 that that WDT cord-333368-kjrk8nn9 117 22 interact interact VBP cord-333368-kjrk8nn9 117 23 with with IN cord-333368-kjrk8nn9 117 24 gene gene NN cord-333368-kjrk8nn9 117 25 expression expression NN cord-333368-kjrk8nn9 117 26 obesity obesity NN cord-333368-kjrk8nn9 117 27 99 99 CD cord-333368-kjrk8nn9 117 28 . . . cord-333368-kjrk8nn9 118 1 While while IN cord-333368-kjrk8nn9 118 2 genetic genetic JJ cord-333368-kjrk8nn9 118 3 factors factor NNS cord-333368-kjrk8nn9 118 4 explain explain VBP cord-333368-kjrk8nn9 118 5 a a DT cord-333368-kjrk8nn9 118 6 small small JJ cord-333368-kjrk8nn9 118 7 part part NN cord-333368-kjrk8nn9 118 8 of of IN cord-333368-kjrk8nn9 118 9 the the DT cord-333368-kjrk8nn9 118 10 risk risk NN cord-333368-kjrk8nn9 118 11 for for IN cord-333368-kjrk8nn9 118 12 developing develop VBG cord-333368-kjrk8nn9 118 13 diabetes diabetes NN cord-333368-kjrk8nn9 118 14 , , , cord-333368-kjrk8nn9 118 15 diabetes diabete VBZ cord-333368-kjrk8nn9 118 16 risk risk NN cord-333368-kjrk8nn9 118 17 genes gene NNS cord-333368-kjrk8nn9 118 18 typically typically RB cord-333368-kjrk8nn9 118 19 do do VBP cord-333368-kjrk8nn9 118 20 not not RB cord-333368-kjrk8nn9 118 21 include include VB cord-333368-kjrk8nn9 118 22 those those DT cord-333368-kjrk8nn9 118 23 related relate VBN cord-333368-kjrk8nn9 118 24 to to IN cord-333368-kjrk8nn9 118 25 antiviral antiviral JJ cord-333368-kjrk8nn9 118 26 immunity immunity NN cord-333368-kjrk8nn9 118 27 100 100 CD cord-333368-kjrk8nn9 118 28 , , , cord-333368-kjrk8nn9 118 29 emphasizing emphasize VBG cord-333368-kjrk8nn9 118 30 that that DT cord-333368-kjrk8nn9 118 31 susceptibility susceptibility NN cord-333368-kjrk8nn9 118 32 to to IN cord-333368-kjrk8nn9 118 33 SARS SARS NNP cord-333368-kjrk8nn9 118 34 - - HYPH cord-333368-kjrk8nn9 118 35 CoV-2 CoV-2 NNP cord-333368-kjrk8nn9 118 36 infection infection NN cord-333368-kjrk8nn9 118 37 or or CC cord-333368-kjrk8nn9 118 38 development development NN cord-333368-kjrk8nn9 118 39 of of IN cord-333368-kjrk8nn9 118 40 severe severe JJ cord-333368-kjrk8nn9 118 41 COVID19 COVID19 NNP cord-333368-kjrk8nn9 118 42 disease disease NN cord-333368-kjrk8nn9 118 43 is be VBZ cord-333368-kjrk8nn9 118 44 likely likely JJ cord-333368-kjrk8nn9 118 45 due due JJ cord-333368-kjrk8nn9 118 46 to to IN cord-333368-kjrk8nn9 118 47 environmental environmental JJ cord-333368-kjrk8nn9 118 48 exposure exposure NN cord-333368-kjrk8nn9 118 49 and and CC cord-333368-kjrk8nn9 118 50 pathophysiology pathophysiology NN cord-333368-kjrk8nn9 118 51 that that WDT cord-333368-kjrk8nn9 118 52 develops develop VBZ cord-333368-kjrk8nn9 118 53 through through IN cord-333368-kjrk8nn9 118 54 the the DT cord-333368-kjrk8nn9 118 55 life life NN cord-333368-kjrk8nn9 118 56 course course NN cord-333368-kjrk8nn9 118 57 , , , cord-333368-kjrk8nn9 118 58 rather rather RB cord-333368-kjrk8nn9 118 59 than than IN cord-333368-kjrk8nn9 118 60 a a DT cord-333368-kjrk8nn9 118 61 common common JJ cord-333368-kjrk8nn9 118 62 predisposing predispose VBG cord-333368-kjrk8nn9 118 63 genotype genotype NN cord-333368-kjrk8nn9 118 64 . . . cord-333368-kjrk8nn9 119 1 In in IN cord-333368-kjrk8nn9 119 2 addition addition NN cord-333368-kjrk8nn9 119 3 to to IN cord-333368-kjrk8nn9 119 4 obesity obesity NN cord-333368-kjrk8nn9 119 5 and and CC cord-333368-kjrk8nn9 119 6 comorbidity comorbidity NN cord-333368-kjrk8nn9 119 7 , , , cord-333368-kjrk8nn9 119 8 male male JJ cord-333368-kjrk8nn9 119 9 sex sex NN cord-333368-kjrk8nn9 119 10 confers confer VBZ cord-333368-kjrk8nn9 119 11 a a DT cord-333368-kjrk8nn9 119 12 significantly significantly RB cord-333368-kjrk8nn9 119 13 increased increase VBN cord-333368-kjrk8nn9 119 14 risk risk NN cord-333368-kjrk8nn9 119 15 of of IN cord-333368-kjrk8nn9 119 16 severe severe JJ cord-333368-kjrk8nn9 119 17 COVID-19 covid-19 JJ cord-333368-kjrk8nn9 119 18 disease disease NN cord-333368-kjrk8nn9 119 19 and and CC cord-333368-kjrk8nn9 119 20 death death NN cord-333368-kjrk8nn9 119 21 14 14 CD cord-333368-kjrk8nn9 119 22 . . . cord-333368-kjrk8nn9 120 1 Differences difference NNS cord-333368-kjrk8nn9 120 2 in in IN cord-333368-kjrk8nn9 120 3 myeloid myeloid JJ cord-333368-kjrk8nn9 120 4 inflammation inflammation NN cord-333368-kjrk8nn9 120 5 among among IN cord-333368-kjrk8nn9 120 6 males male NNS cord-333368-kjrk8nn9 120 7 and and CC cord-333368-kjrk8nn9 120 8 females female NNS cord-333368-kjrk8nn9 120 9 may may MD cord-333368-kjrk8nn9 120 10 play play VB cord-333368-kjrk8nn9 120 11 a a DT cord-333368-kjrk8nn9 120 12 protective protective JJ cord-333368-kjrk8nn9 120 13 role role NN cord-333368-kjrk8nn9 120 14 in in IN cord-333368-kjrk8nn9 120 15 the the DT cord-333368-kjrk8nn9 120 16 immunopathology immunopathology NN cord-333368-kjrk8nn9 120 17 of of IN cord-333368-kjrk8nn9 120 18 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 120 19 , , , cord-333368-kjrk8nn9 120 20 especially especially RB cord-333368-kjrk8nn9 120 21 in in IN cord-333368-kjrk8nn9 120 22 the the DT cord-333368-kjrk8nn9 120 23 setting setting NN cord-333368-kjrk8nn9 120 24 of of IN cord-333368-kjrk8nn9 120 25 obesity obesity NN cord-333368-kjrk8nn9 120 26 . . . cord-333368-kjrk8nn9 121 1 A a DT cord-333368-kjrk8nn9 121 2 c c NN cord-333368-kjrk8nn9 121 3 c c NN cord-333368-kjrk8nn9 121 4 e e NN cord-333368-kjrk8nn9 121 5 p p NN cord-333368-kjrk8nn9 121 6 t t NN cord-333368-kjrk8nn9 121 7 e e NN cord-333368-kjrk8nn9 121 8 d d NNP cord-333368-kjrk8nn9 121 9 M M NNP cord-333368-kjrk8nn9 121 10 a a NNP cord-333368-kjrk8nn9 121 11 n n NN cord-333368-kjrk8nn9 121 12 u u NNP cord-333368-kjrk8nn9 121 13 s s NNP cord-333368-kjrk8nn9 121 14 c c NN cord-333368-kjrk8nn9 121 15 r r NN cord-333368-kjrk8nn9 121 16 i i NN cord-333368-kjrk8nn9 121 17 p p NN cord-333368-kjrk8nn9 121 18 t t NN cord-333368-kjrk8nn9 121 19 13 13 CD cord-333368-kjrk8nn9 122 1 Not not RB cord-333368-kjrk8nn9 122 2 all all DT cord-333368-kjrk8nn9 122 3 obese obese JJ cord-333368-kjrk8nn9 122 4 individuals individual NNS cord-333368-kjrk8nn9 122 5 are be VBP cord-333368-kjrk8nn9 122 6 at at IN cord-333368-kjrk8nn9 122 7 risk risk NN cord-333368-kjrk8nn9 122 8 for for IN cord-333368-kjrk8nn9 122 9 metabolic metabolic JJ cord-333368-kjrk8nn9 122 10 and and CC cord-333368-kjrk8nn9 122 11 cardiovascular cardiovascular JJ cord-333368-kjrk8nn9 122 12 disease disease NN cord-333368-kjrk8nn9 122 13 102 102 CD cord-333368-kjrk8nn9 122 14 and and CC cord-333368-kjrk8nn9 122 15 not not RB cord-333368-kjrk8nn9 122 16 all all DT cord-333368-kjrk8nn9 122 17 obese obese JJ cord-333368-kjrk8nn9 122 18 develop develop VBP cord-333368-kjrk8nn9 122 19 obesity obesity NN cord-333368-kjrk8nn9 122 20 induced induce VBN cord-333368-kjrk8nn9 122 21 inflammation inflammation NN cord-333368-kjrk8nn9 122 22 to to IN cord-333368-kjrk8nn9 122 23 the the DT cord-333368-kjrk8nn9 122 24 same same JJ cord-333368-kjrk8nn9 122 25 degree degree NN cord-333368-kjrk8nn9 122 26 103 103 CD cord-333368-kjrk8nn9 122 27 . . . cord-333368-kjrk8nn9 123 1 Increased increase VBN cord-333368-kjrk8nn9 123 2 androgen androgen NN cord-333368-kjrk8nn9 123 3 concentration concentration NN cord-333368-kjrk8nn9 123 4 in in IN cord-333368-kjrk8nn9 123 5 males male NNS cord-333368-kjrk8nn9 123 6 is be VBZ cord-333368-kjrk8nn9 123 7 also also RB cord-333368-kjrk8nn9 123 8 thought think VBN cord-333368-kjrk8nn9 123 9 to to TO cord-333368-kjrk8nn9 123 10 lead lead VB cord-333368-kjrk8nn9 123 11 to to IN cord-333368-kjrk8nn9 123 12 increased increase VBN cord-333368-kjrk8nn9 123 13 IL-10 IL-10 NNP cord-333368-kjrk8nn9 123 14 production production NN cord-333368-kjrk8nn9 123 15 when when WRB cord-333368-kjrk8nn9 123 16 peripheral peripheral JJ cord-333368-kjrk8nn9 123 17 blood blood NN cord-333368-kjrk8nn9 123 18 mononuclear mononuclear NN cord-333368-kjrk8nn9 123 19 cells cell NNS cord-333368-kjrk8nn9 123 20 are be VBP cord-333368-kjrk8nn9 123 21 stimulated stimulate VBN cord-333368-kjrk8nn9 123 22 by by IN cord-333368-kjrk8nn9 123 23 viral viral JJ cord-333368-kjrk8nn9 123 24 antigens antigen NNS cord-333368-kjrk8nn9 123 25 , , , cord-333368-kjrk8nn9 123 26 leading lead VBG cord-333368-kjrk8nn9 123 27 to to IN cord-333368-kjrk8nn9 123 28 a a DT cord-333368-kjrk8nn9 123 29 delayed delay VBN cord-333368-kjrk8nn9 123 30 and and CC cord-333368-kjrk8nn9 123 31 diminished diminish VBN cord-333368-kjrk8nn9 123 32 pro pro JJ cord-333368-kjrk8nn9 123 33 - - JJ cord-333368-kjrk8nn9 123 34 inflammatory inflammatory JJ cord-333368-kjrk8nn9 123 35 response response NN cord-333368-kjrk8nn9 123 36 which which WDT cord-333368-kjrk8nn9 123 37 may may MD cord-333368-kjrk8nn9 123 38 also also RB cord-333368-kjrk8nn9 123 39 explain explain VB cord-333368-kjrk8nn9 123 40 disease disease NN cord-333368-kjrk8nn9 123 41 severity severity NN cord-333368-kjrk8nn9 123 42 104 104 CD cord-333368-kjrk8nn9 123 43 . . . cord-333368-kjrk8nn9 124 1 Additionally additionally RB cord-333368-kjrk8nn9 124 2 , , , cord-333368-kjrk8nn9 124 3 males male NNS cord-333368-kjrk8nn9 124 4 tend tend VBP cord-333368-kjrk8nn9 124 5 to to TO cord-333368-kjrk8nn9 124 6 have have VB cord-333368-kjrk8nn9 124 7 increased increase VBN cord-333368-kjrk8nn9 124 8 levels level NNS cord-333368-kjrk8nn9 124 9 of of IN cord-333368-kjrk8nn9 124 10 proinflammatory proinflammatory JJ cord-333368-kjrk8nn9 124 11 cytokines cytokine NNS cord-333368-kjrk8nn9 124 12 and and CC cord-333368-kjrk8nn9 124 13 chemokines chemokine NNS cord-333368-kjrk8nn9 124 14 after after IN cord-333368-kjrk8nn9 124 15 stimulation stimulation NN cord-333368-kjrk8nn9 124 16 with with IN cord-333368-kjrk8nn9 124 17 LPS LPS NNP cord-333368-kjrk8nn9 124 18 intraperitoneally intraperitoneally RB cord-333368-kjrk8nn9 124 19 in in IN cord-333368-kjrk8nn9 124 20 vivo vivo NN cord-333368-kjrk8nn9 124 21 and and CC cord-333368-kjrk8nn9 124 22 in in IN cord-333368-kjrk8nn9 124 23 in in FW cord-333368-kjrk8nn9 124 24 vitro vitro FW cord-333368-kjrk8nn9 124 25 assays assay NNS cord-333368-kjrk8nn9 124 26 105 105 CD cord-333368-kjrk8nn9 124 27 , , , cord-333368-kjrk8nn9 124 28 106 106 CD cord-333368-kjrk8nn9 124 29 . . . cord-333368-kjrk8nn9 125 1 Hence hence RB cord-333368-kjrk8nn9 125 2 , , , cord-333368-kjrk8nn9 125 3 this this DT cord-333368-kjrk8nn9 125 4 difference difference NN cord-333368-kjrk8nn9 125 5 by by IN cord-333368-kjrk8nn9 125 6 sex sex NN cord-333368-kjrk8nn9 125 7 and and CC cord-333368-kjrk8nn9 125 8 due due IN cord-333368-kjrk8nn9 125 9 to to IN cord-333368-kjrk8nn9 125 10 sex sex NN cord-333368-kjrk8nn9 125 11 hormones hormone NNS cord-333368-kjrk8nn9 125 12 could could MD cord-333368-kjrk8nn9 125 13 lead lead VB cord-333368-kjrk8nn9 125 14 to to IN cord-333368-kjrk8nn9 125 15 a a DT cord-333368-kjrk8nn9 125 16 possible possible JJ cord-333368-kjrk8nn9 125 17 increased increase VBN cord-333368-kjrk8nn9 125 18 cytokine cytokine NN cord-333368-kjrk8nn9 125 19 storm storm NN cord-333368-kjrk8nn9 125 20 in in IN cord-333368-kjrk8nn9 125 21 males male NNS cord-333368-kjrk8nn9 125 22 with with IN cord-333368-kjrk8nn9 125 23 obesity obesity NN cord-333368-kjrk8nn9 125 24 107 107 CD cord-333368-kjrk8nn9 125 25 , , , cord-333368-kjrk8nn9 125 26 and and CC cord-333368-kjrk8nn9 125 27 explain explain VB cord-333368-kjrk8nn9 125 28 the the DT cord-333368-kjrk8nn9 125 29 pathologic pathologic JJ cord-333368-kjrk8nn9 125 30 response response NN cord-333368-kjrk8nn9 125 31 and and CC cord-333368-kjrk8nn9 125 32 enhanced enhanced JJ cord-333368-kjrk8nn9 125 33 morbidity morbidity NN cord-333368-kjrk8nn9 125 34 described describe VBN cord-333368-kjrk8nn9 125 35 clinically clinically RB cord-333368-kjrk8nn9 125 36 . . . cord-333368-kjrk8nn9 126 1 Pre pre JJ cord-333368-kjrk8nn9 126 2 - - JJ cord-333368-kjrk8nn9 126 3 menopausal menopausal JJ cord-333368-kjrk8nn9 126 4 females female NNS cord-333368-kjrk8nn9 126 5 are be VBP cord-333368-kjrk8nn9 126 6 relatively relatively RB cord-333368-kjrk8nn9 126 7 protected protect VBN cord-333368-kjrk8nn9 126 8 from from IN cord-333368-kjrk8nn9 126 9 obesity obesity NN cord-333368-kjrk8nn9 126 10 induced induce VBN cord-333368-kjrk8nn9 126 11 inflammation inflammation NN cord-333368-kjrk8nn9 126 12 , , , cord-333368-kjrk8nn9 126 13 macrophage macrophage NN cord-333368-kjrk8nn9 126 14 activation activation NN cord-333368-kjrk8nn9 126 15 , , , cord-333368-kjrk8nn9 126 16 and and CC cord-333368-kjrk8nn9 126 17 expansion expansion NN cord-333368-kjrk8nn9 126 18 of of IN cord-333368-kjrk8nn9 126 19 myeloid myeloid JJ cord-333368-kjrk8nn9 126 20 progenitors progenitor NNS cord-333368-kjrk8nn9 126 21 and and CC cord-333368-kjrk8nn9 126 22 are be VBP cord-333368-kjrk8nn9 126 23 relatively relatively RB cord-333368-kjrk8nn9 126 24 protected protect VBN cord-333368-kjrk8nn9 126 25 from from IN cord-333368-kjrk8nn9 126 26 metabolic metabolic JJ cord-333368-kjrk8nn9 126 27 and and CC cord-333368-kjrk8nn9 126 28 cardiovascular cardiovascular JJ cord-333368-kjrk8nn9 126 29 disease disease NN cord-333368-kjrk8nn9 126 30 108 108 CD cord-333368-kjrk8nn9 126 31 . . . cord-333368-kjrk8nn9 127 1 In in IN cord-333368-kjrk8nn9 127 2 pre pre JJ cord-333368-kjrk8nn9 127 3 - - JJ cord-333368-kjrk8nn9 127 4 clinical clinical JJ cord-333368-kjrk8nn9 127 5 models model NNS cord-333368-kjrk8nn9 127 6 , , , cord-333368-kjrk8nn9 127 7 females female NNS cord-333368-kjrk8nn9 127 8 are be VBP cord-333368-kjrk8nn9 127 9 protected protect VBN cord-333368-kjrk8nn9 127 10 from from IN cord-333368-kjrk8nn9 127 11 meta meta JJ cord-333368-kjrk8nn9 127 12 - - HYPH cord-333368-kjrk8nn9 127 13 inflammation inflammation NN cord-333368-kjrk8nn9 127 14 [ [ -LRB- cord-333368-kjrk8nn9 127 15 108 108 CD cord-333368-kjrk8nn9 127 16 ] ] -RRB- cord-333368-kjrk8nn9 127 17 [ [ -LRB- cord-333368-kjrk8nn9 127 18 109 109 CD cord-333368-kjrk8nn9 127 19 ] ] -RRB- cord-333368-kjrk8nn9 127 20 [ [ -LRB- cord-333368-kjrk8nn9 127 21 110 110 CD cord-333368-kjrk8nn9 127 22 ] ] -RRB- cord-333368-kjrk8nn9 127 23 [ [ -LRB- cord-333368-kjrk8nn9 127 24 111 111 CD cord-333368-kjrk8nn9 127 25 ] ] -RRB- cord-333368-kjrk8nn9 127 26 . . . cord-333368-kjrk8nn9 128 1 One one CD cord-333368-kjrk8nn9 128 2 explanation explanation NN cord-333368-kjrk8nn9 128 3 for for IN cord-333368-kjrk8nn9 128 4 this this DT cord-333368-kjrk8nn9 128 5 is be VBZ cord-333368-kjrk8nn9 128 6 that that IN cord-333368-kjrk8nn9 128 7 females female NNS cord-333368-kjrk8nn9 128 8 generally generally RB cord-333368-kjrk8nn9 128 9 handle handle VBP cord-333368-kjrk8nn9 128 10 the the DT cord-333368-kjrk8nn9 128 11 expansion expansion NN cord-333368-kjrk8nn9 128 12 of of IN cord-333368-kjrk8nn9 128 13 adipocytes adipocyte NNS cord-333368-kjrk8nn9 128 14 with with IN cord-333368-kjrk8nn9 128 15 resident resident JJ cord-333368-kjrk8nn9 128 16 macrophage macrophage NN cord-333368-kjrk8nn9 128 17 proliferation proliferation NN cord-333368-kjrk8nn9 128 18 without without IN cord-333368-kjrk8nn9 128 19 recruitment recruitment NN cord-333368-kjrk8nn9 128 20 of of IN cord-333368-kjrk8nn9 128 21 pro pro JJ cord-333368-kjrk8nn9 128 22 - - JJ cord-333368-kjrk8nn9 128 23 inflammatory inflammatory JJ cord-333368-kjrk8nn9 128 24 macrophages macrophage NNS cord-333368-kjrk8nn9 128 25 109 109 CD cord-333368-kjrk8nn9 128 26 . . . cord-333368-kjrk8nn9 129 1 This this DT cord-333368-kjrk8nn9 129 2 finding finding NN cord-333368-kjrk8nn9 129 3 that that IN cord-333368-kjrk8nn9 129 4 all all DT cord-333368-kjrk8nn9 129 5 macrophages macrophage NNS cord-333368-kjrk8nn9 129 6 are be VBP cord-333368-kjrk8nn9 129 7 not not RB cord-333368-kjrk8nn9 129 8 the the DT cord-333368-kjrk8nn9 129 9 same same JJ cord-333368-kjrk8nn9 129 10 in in IN cord-333368-kjrk8nn9 129 11 responsiveness responsiveness NN cord-333368-kjrk8nn9 129 12 to to IN cord-333368-kjrk8nn9 129 13 obesity obesity NN cord-333368-kjrk8nn9 129 14 but but CC cord-333368-kjrk8nn9 129 15 that that IN cord-333368-kjrk8nn9 129 16 the the DT cord-333368-kjrk8nn9 129 17 overall overall JJ cord-333368-kjrk8nn9 129 18 trend trend NN cord-333368-kjrk8nn9 129 19 is be VBZ cord-333368-kjrk8nn9 129 20 pro pro JJ cord-333368-kjrk8nn9 129 21 - - JJ cord-333368-kjrk8nn9 129 22 inflammatory inflammatory JJ cord-333368-kjrk8nn9 129 23 in in IN cord-333368-kjrk8nn9 129 24 nature nature NN cord-333368-kjrk8nn9 129 25 requires require VBZ cord-333368-kjrk8nn9 129 26 further further JJ cord-333368-kjrk8nn9 129 27 investigation investigation NN cord-333368-kjrk8nn9 129 28 into into IN cord-333368-kjrk8nn9 129 29 the the DT cord-333368-kjrk8nn9 129 30 overall overall JJ cord-333368-kjrk8nn9 129 31 macrophage macrophage NN cord-333368-kjrk8nn9 129 32 phenotype phenotype NN cord-333368-kjrk8nn9 129 33 with with IN cord-333368-kjrk8nn9 129 34 obesity obesity NN cord-333368-kjrk8nn9 129 35 . . . cord-333368-kjrk8nn9 130 1 In in IN cord-333368-kjrk8nn9 130 2 the the DT cord-333368-kjrk8nn9 130 3 context context NN cord-333368-kjrk8nn9 130 4 of of IN cord-333368-kjrk8nn9 130 5 infection infection NN cord-333368-kjrk8nn9 130 6 though though RB cord-333368-kjrk8nn9 130 7 , , , cord-333368-kjrk8nn9 130 8 those those DT cord-333368-kjrk8nn9 130 9 with with IN cord-333368-kjrk8nn9 130 10 pro pro JJ cord-333368-kjrk8nn9 130 11 - - JJ cord-333368-kjrk8nn9 130 12 inflammatory inflammatory JJ cord-333368-kjrk8nn9 130 13 macrophages macrophage NNS cord-333368-kjrk8nn9 130 14 can can MD cord-333368-kjrk8nn9 130 15 produce produce VB cord-333368-kjrk8nn9 130 16 an an DT cord-333368-kjrk8nn9 130 17 enhanced enhance VBN cord-333368-kjrk8nn9 130 18 cytokine cytokine NN cord-333368-kjrk8nn9 130 19 environment environment NN cord-333368-kjrk8nn9 130 20 leading lead VBG cord-333368-kjrk8nn9 130 21 to to IN cord-333368-kjrk8nn9 130 22 severity severity NN cord-333368-kjrk8nn9 130 23 of of IN cord-333368-kjrk8nn9 130 24 illness illness NN cord-333368-kjrk8nn9 130 25 in in IN cord-333368-kjrk8nn9 130 26 obese obese JJ cord-333368-kjrk8nn9 130 27 individuals individual NNS cord-333368-kjrk8nn9 130 28 via via IN cord-333368-kjrk8nn9 130 29 both both CC cord-333368-kjrk8nn9 130 30 systemic systemic JJ cord-333368-kjrk8nn9 130 31 and and CC cord-333368-kjrk8nn9 130 32 local local JJ cord-333368-kjrk8nn9 130 33 lung lung NN cord-333368-kjrk8nn9 130 34 effects effect NNS cord-333368-kjrk8nn9 130 35 112 112 CD cord-333368-kjrk8nn9 130 36 , , , cord-333368-kjrk8nn9 130 37 113 113 CD cord-333368-kjrk8nn9 130 38 . . . cord-333368-kjrk8nn9 131 1 While while IN cord-333368-kjrk8nn9 131 2 the the DT cord-333368-kjrk8nn9 131 3 interaction interaction NN cord-333368-kjrk8nn9 131 4 of of IN cord-333368-kjrk8nn9 131 5 sex sex NN cord-333368-kjrk8nn9 131 6 and and CC cord-333368-kjrk8nn9 131 7 diet diet NN cord-333368-kjrk8nn9 131 8 induced induce VBN cord-333368-kjrk8nn9 131 9 obesity obesity NN cord-333368-kjrk8nn9 131 10 has have VBZ cord-333368-kjrk8nn9 131 11 been be VBN cord-333368-kjrk8nn9 131 12 most most RBS cord-333368-kjrk8nn9 131 13 elucidated elucidate VBN cord-333368-kjrk8nn9 131 14 in in IN cord-333368-kjrk8nn9 131 15 the the DT cord-333368-kjrk8nn9 131 16 setting setting NN cord-333368-kjrk8nn9 131 17 of of IN cord-333368-kjrk8nn9 131 18 innate innate JJ cord-333368-kjrk8nn9 131 19 immune immune JJ cord-333368-kjrk8nn9 131 20 cell cell NN cord-333368-kjrk8nn9 131 21 populations population NNS cord-333368-kjrk8nn9 131 22 , , , cord-333368-kjrk8nn9 131 23 sex sex NN cord-333368-kjrk8nn9 131 24 hormone hormone NN cord-333368-kjrk8nn9 131 25 receptors receptor NNS cord-333368-kjrk8nn9 131 26 are be VBP cord-333368-kjrk8nn9 131 27 present present JJ cord-333368-kjrk8nn9 131 28 on on IN cord-333368-kjrk8nn9 131 29 cells cell NNS cord-333368-kjrk8nn9 131 30 of of IN cord-333368-kjrk8nn9 131 31 the the DT cord-333368-kjrk8nn9 131 32 adaptive adaptive JJ cord-333368-kjrk8nn9 131 33 immune immune JJ cord-333368-kjrk8nn9 131 34 system system NN cord-333368-kjrk8nn9 131 35 as as RB cord-333368-kjrk8nn9 131 36 well well RB cord-333368-kjrk8nn9 131 37 , , , cord-333368-kjrk8nn9 131 38 and and CC cord-333368-kjrk8nn9 131 39 sexual sexual JJ cord-333368-kjrk8nn9 131 40 dimorphism dimorphism NN cord-333368-kjrk8nn9 131 41 in in IN cord-333368-kjrk8nn9 131 42 autoimmunity autoimmunity NN cord-333368-kjrk8nn9 131 43 and and CC cord-333368-kjrk8nn9 131 44 humoral humoral JJ cord-333368-kjrk8nn9 131 45 responses response NNS cord-333368-kjrk8nn9 131 46 has have VBZ cord-333368-kjrk8nn9 131 47 been be VBN cord-333368-kjrk8nn9 131 48 noted note VBN cord-333368-kjrk8nn9 131 49 for for IN cord-333368-kjrk8nn9 131 50 A a DT cord-333368-kjrk8nn9 131 51 c c NN cord-333368-kjrk8nn9 131 52 c c NN cord-333368-kjrk8nn9 131 53 e e NN cord-333368-kjrk8nn9 131 54 p p NN cord-333368-kjrk8nn9 131 55 t t NN cord-333368-kjrk8nn9 131 56 e e NN cord-333368-kjrk8nn9 131 57 d d NNP cord-333368-kjrk8nn9 131 58 M M NNP cord-333368-kjrk8nn9 131 59 a a NNP cord-333368-kjrk8nn9 132 1 n n CC cord-333368-kjrk8nn9 132 2 u u NNP cord-333368-kjrk8nn9 132 3 s s NNP cord-333368-kjrk8nn9 132 4 c c NN cord-333368-kjrk8nn9 132 5 r r NN cord-333368-kjrk8nn9 132 6 i i PRP cord-333368-kjrk8nn9 133 1 p p NN cord-333368-kjrk8nn9 133 2 t t NN cord-333368-kjrk8nn9 133 3 14 14 CD cord-333368-kjrk8nn9 133 4 decades decade NNS cord-333368-kjrk8nn9 133 5 114 114 CD cord-333368-kjrk8nn9 133 6 . . . cord-333368-kjrk8nn9 134 1 These these DT cord-333368-kjrk8nn9 134 2 differences difference NNS cord-333368-kjrk8nn9 134 3 may may MD cord-333368-kjrk8nn9 134 4 also also RB cord-333368-kjrk8nn9 134 5 be be VB cord-333368-kjrk8nn9 134 6 critical critical JJ cord-333368-kjrk8nn9 134 7 in in IN cord-333368-kjrk8nn9 134 8 favoring favor VBG cord-333368-kjrk8nn9 134 9 antiviral antiviral JJ cord-333368-kjrk8nn9 134 10 immunity immunity NN cord-333368-kjrk8nn9 134 11 in in IN cord-333368-kjrk8nn9 134 12 females female NNS cord-333368-kjrk8nn9 134 13 . . . cord-333368-kjrk8nn9 135 1 Of of IN cord-333368-kjrk8nn9 135 2 particular particular JJ cord-333368-kjrk8nn9 135 3 note note NN cord-333368-kjrk8nn9 135 4 , , , cord-333368-kjrk8nn9 135 5 female female JJ cord-333368-kjrk8nn9 135 6 mice mouse NNS cord-333368-kjrk8nn9 135 7 expand expand VBP cord-333368-kjrk8nn9 135 8 the the DT cord-333368-kjrk8nn9 135 9 population population NN cord-333368-kjrk8nn9 135 10 of of IN cord-333368-kjrk8nn9 135 11 regulatory regulatory JJ cord-333368-kjrk8nn9 135 12 T t NN cord-333368-kjrk8nn9 135 13 - - HYPH cord-333368-kjrk8nn9 135 14 cells cell NNS cord-333368-kjrk8nn9 135 15 significantly significantly RB cord-333368-kjrk8nn9 135 16 compared compare VBN cord-333368-kjrk8nn9 135 17 to to IN cord-333368-kjrk8nn9 135 18 male male JJ cord-333368-kjrk8nn9 135 19 mice mouse NNS cord-333368-kjrk8nn9 135 20 in in IN cord-333368-kjrk8nn9 135 21 obesity obesity NN cord-333368-kjrk8nn9 135 22 115 115 CD cord-333368-kjrk8nn9 135 23 . . . cord-333368-kjrk8nn9 136 1 This this DT cord-333368-kjrk8nn9 136 2 cell cell NN cord-333368-kjrk8nn9 136 3 population population NN cord-333368-kjrk8nn9 136 4 is be VBZ cord-333368-kjrk8nn9 136 5 noted note VBN cord-333368-kjrk8nn9 136 6 to to TO cord-333368-kjrk8nn9 136 7 be be VB cord-333368-kjrk8nn9 136 8 deficient deficient JJ cord-333368-kjrk8nn9 136 9 in in IN cord-333368-kjrk8nn9 136 10 obese obese JJ cord-333368-kjrk8nn9 136 11 male male JJ cord-333368-kjrk8nn9 136 12 mice mouse NNS cord-333368-kjrk8nn9 136 13 during during IN cord-333368-kjrk8nn9 136 14 influenza influenza NN cord-333368-kjrk8nn9 136 15 infection infection NN cord-333368-kjrk8nn9 136 16 54 54 CD cord-333368-kjrk8nn9 136 17 and and CC cord-333368-kjrk8nn9 136 18 may may MD cord-333368-kjrk8nn9 136 19 play play VB cord-333368-kjrk8nn9 136 20 a a DT cord-333368-kjrk8nn9 136 21 role role NN cord-333368-kjrk8nn9 136 22 in in IN cord-333368-kjrk8nn9 136 23 limiting limit VBG cord-333368-kjrk8nn9 136 24 lung lung NN cord-333368-kjrk8nn9 136 25 injury injury NN cord-333368-kjrk8nn9 136 26 in in IN cord-333368-kjrk8nn9 136 27 the the DT cord-333368-kjrk8nn9 136 28 setting setting NN cord-333368-kjrk8nn9 136 29 of of IN cord-333368-kjrk8nn9 136 30 viral viral JJ cord-333368-kjrk8nn9 136 31 infection infection NN cord-333368-kjrk8nn9 136 32 . . . cord-333368-kjrk8nn9 137 1 Individuals individual NNS cord-333368-kjrk8nn9 137 2 of of IN cord-333368-kjrk8nn9 137 3 all all DT cord-333368-kjrk8nn9 137 4 ages age NNS cord-333368-kjrk8nn9 137 5 are be VBP cord-333368-kjrk8nn9 137 6 at at IN cord-333368-kjrk8nn9 137 7 risk risk NN cord-333368-kjrk8nn9 137 8 for for IN cord-333368-kjrk8nn9 137 9 obesity obesity NN cord-333368-kjrk8nn9 137 10 , , , cord-333368-kjrk8nn9 137 11 but but CC cord-333368-kjrk8nn9 137 12 it -PRON- PRP cord-333368-kjrk8nn9 137 13 is be VBZ cord-333368-kjrk8nn9 137 14 not not RB cord-333368-kjrk8nn9 137 15 clear clear JJ cord-333368-kjrk8nn9 137 16 if if IN cord-333368-kjrk8nn9 137 17 weight weight NN cord-333368-kjrk8nn9 137 18 status status NN cord-333368-kjrk8nn9 137 19 influences influence NNS cord-333368-kjrk8nn9 137 20 what what WP cord-333368-kjrk8nn9 137 21 has have VBZ cord-333368-kjrk8nn9 137 22 been be VBN cord-333368-kjrk8nn9 137 23 seen see VBN cord-333368-kjrk8nn9 137 24 with with IN cord-333368-kjrk8nn9 137 25 age age NN cord-333368-kjrk8nn9 137 26 related related JJ cord-333368-kjrk8nn9 137 27 risk risk NN cord-333368-kjrk8nn9 137 28 for for IN cord-333368-kjrk8nn9 137 29 COVID covid JJ cord-333368-kjrk8nn9 137 30 severity severity NN cord-333368-kjrk8nn9 137 31 . . . cord-333368-kjrk8nn9 138 1 Of of IN cord-333368-kjrk8nn9 138 2 patients patient NNS cord-333368-kjrk8nn9 138 3 aged aged JJ cord-333368-kjrk8nn9 138 4 19 19 CD cord-333368-kjrk8nn9 138 5 - - SYM cord-333368-kjrk8nn9 138 6 64 64 CD cord-333368-kjrk8nn9 138 7 years year NNS cord-333368-kjrk8nn9 138 8 admitted admit VBN cord-333368-kjrk8nn9 138 9 to to IN cord-333368-kjrk8nn9 138 10 the the DT cord-333368-kjrk8nn9 138 11 hospital hospital NN cord-333368-kjrk8nn9 138 12 , , , cord-333368-kjrk8nn9 138 13 those those DT cord-333368-kjrk8nn9 138 14 with with IN cord-333368-kjrk8nn9 138 15 co co NNS cord-333368-kjrk8nn9 138 16 - - NNS cord-333368-kjrk8nn9 138 17 morbidities morbidity NNS cord-333368-kjrk8nn9 138 18 caused cause VBN cord-333368-kjrk8nn9 138 19 by by IN cord-333368-kjrk8nn9 138 20 high high JJ cord-333368-kjrk8nn9 138 21 BMI BMI NNP cord-333368-kjrk8nn9 138 22 were be VBD cord-333368-kjrk8nn9 138 23 more more RBR cord-333368-kjrk8nn9 138 24 likely likely JJ cord-333368-kjrk8nn9 138 25 to to TO cord-333368-kjrk8nn9 138 26 be be VB cord-333368-kjrk8nn9 138 27 admitted admit VBN cord-333368-kjrk8nn9 138 28 to to IN cord-333368-kjrk8nn9 138 29 the the DT cord-333368-kjrk8nn9 138 30 ICU ICU NNP cord-333368-kjrk8nn9 138 31 63 63 CD cord-333368-kjrk8nn9 138 32 and and CC cord-333368-kjrk8nn9 138 33 this this DT cord-333368-kjrk8nn9 138 34 is be VBZ cord-333368-kjrk8nn9 138 35 true true JJ cord-333368-kjrk8nn9 138 36 regardless regardless RB cord-333368-kjrk8nn9 138 37 of of IN cord-333368-kjrk8nn9 138 38 sex sex NN cord-333368-kjrk8nn9 138 39 10 10 CD cord-333368-kjrk8nn9 138 40 . . . cord-333368-kjrk8nn9 139 1 As as IN cord-333368-kjrk8nn9 139 2 humans human NNS cord-333368-kjrk8nn9 139 3 age age NN cord-333368-kjrk8nn9 139 4 , , , cord-333368-kjrk8nn9 139 5 the the DT cord-333368-kjrk8nn9 139 6 immune immune JJ cord-333368-kjrk8nn9 139 7 system system NN cord-333368-kjrk8nn9 139 8 changes change VBZ cord-333368-kjrk8nn9 139 9 116 116 CD cord-333368-kjrk8nn9 139 10 , , , cord-333368-kjrk8nn9 139 11 with with IN cord-333368-kjrk8nn9 139 12 a a DT cord-333368-kjrk8nn9 139 13 decreased decreased JJ cord-333368-kjrk8nn9 139 14 number number NN cord-333368-kjrk8nn9 139 15 of of IN cord-333368-kjrk8nn9 139 16 lymphocytes lymphocyte NNS cord-333368-kjrk8nn9 139 17 , , , cord-333368-kjrk8nn9 139 18 which which WDT cord-333368-kjrk8nn9 139 19 are be VBP cord-333368-kjrk8nn9 139 20 important important JJ cord-333368-kjrk8nn9 139 21 cells cell NNS cord-333368-kjrk8nn9 139 22 for for IN cord-333368-kjrk8nn9 139 23 fighting fight VBG cord-333368-kjrk8nn9 139 24 viruses virus NNS cord-333368-kjrk8nn9 139 25 . . . cord-333368-kjrk8nn9 140 1 This this DT cord-333368-kjrk8nn9 140 2 has have VBZ cord-333368-kjrk8nn9 140 3 proved prove VBN cord-333368-kjrk8nn9 140 4 to to TO cord-333368-kjrk8nn9 140 5 be be VB cord-333368-kjrk8nn9 140 6 a a DT cord-333368-kjrk8nn9 140 7 significant significant JJ cord-333368-kjrk8nn9 140 8 disadvantage disadvantage NN cord-333368-kjrk8nn9 140 9 during during IN cord-333368-kjrk8nn9 140 10 past past JJ cord-333368-kjrk8nn9 140 11 epidemics epidemic NNS cord-333368-kjrk8nn9 140 12 , , , cord-333368-kjrk8nn9 140 13 such such JJ cord-333368-kjrk8nn9 140 14 as as IN cord-333368-kjrk8nn9 140 15 SARS SARS NNP cord-333368-kjrk8nn9 140 16 117 117 CD cord-333368-kjrk8nn9 140 17 . . . cord-333368-kjrk8nn9 141 1 While while IN cord-333368-kjrk8nn9 141 2 elderly elderly JJ cord-333368-kjrk8nn9 141 3 individuals individual NNS cord-333368-kjrk8nn9 141 4 are be VBP cord-333368-kjrk8nn9 141 5 at at IN cord-333368-kjrk8nn9 141 6 increased increase VBN cord-333368-kjrk8nn9 141 7 risk risk NN cord-333368-kjrk8nn9 141 8 for for IN cord-333368-kjrk8nn9 141 9 severe severe JJ cord-333368-kjrk8nn9 141 10 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 141 11 , , , cord-333368-kjrk8nn9 141 12 the the DT cord-333368-kjrk8nn9 141 13 obesity obesity NN cord-333368-kjrk8nn9 141 14 epidemic epidemic NN cord-333368-kjrk8nn9 141 15 is be VBZ cord-333368-kjrk8nn9 141 16 shifting shift VBG cord-333368-kjrk8nn9 141 17 to to IN cord-333368-kjrk8nn9 141 18 the the DT cord-333368-kjrk8nn9 141 19 most most RBS cord-333368-kjrk8nn9 141 20 targeted target VBN cord-333368-kjrk8nn9 141 21 demographic demographic JJ cord-333368-kjrk8nn9 141 22 to to IN cord-333368-kjrk8nn9 141 23 a a DT cord-333368-kjrk8nn9 141 24 younger young JJR cord-333368-kjrk8nn9 141 25 age age NN cord-333368-kjrk8nn9 141 26 group group NN cord-333368-kjrk8nn9 141 27 . . . cord-333368-kjrk8nn9 142 1 Younger young JJR cord-333368-kjrk8nn9 142 2 COVID covid JJ cord-333368-kjrk8nn9 142 3 patients patient NNS cord-333368-kjrk8nn9 142 4 are be VBP cord-333368-kjrk8nn9 142 5 likely likely JJ cord-333368-kjrk8nn9 142 6 to to TO cord-333368-kjrk8nn9 142 7 have have VB cord-333368-kjrk8nn9 142 8 a a DT cord-333368-kjrk8nn9 142 9 higher high JJR cord-333368-kjrk8nn9 142 10 BMI bmi NN cord-333368-kjrk8nn9 142 11 then then RB cord-333368-kjrk8nn9 142 12 older old JJR cord-333368-kjrk8nn9 142 13 patients patient NNS cord-333368-kjrk8nn9 142 14 while while IN cord-333368-kjrk8nn9 142 15 this this DT cord-333368-kjrk8nn9 142 16 same same JJ cord-333368-kjrk8nn9 142 17 trend trend NN cord-333368-kjrk8nn9 142 18 did do VBD cord-333368-kjrk8nn9 142 19 not not RB cord-333368-kjrk8nn9 142 20 exist exist VB cord-333368-kjrk8nn9 142 21 in in IN cord-333368-kjrk8nn9 142 22 non non JJ cord-333368-kjrk8nn9 142 23 - - JJ cord-333368-kjrk8nn9 142 24 COVID covid JJ cord-333368-kjrk8nn9 142 25 admissions admission NNS cord-333368-kjrk8nn9 142 26 118 118 CD cord-333368-kjrk8nn9 142 27 . . . cord-333368-kjrk8nn9 143 1 Age age NN cord-333368-kjrk8nn9 143 2 related related JJ cord-333368-kjrk8nn9 143 3 changes change NNS cord-333368-kjrk8nn9 143 4 in in IN cord-333368-kjrk8nn9 143 5 metabolic metabolic JJ cord-333368-kjrk8nn9 143 6 inflammation inflammation NN cord-333368-kjrk8nn9 143 7 are be VBP cord-333368-kjrk8nn9 143 8 still still RB cord-333368-kjrk8nn9 143 9 being be VBG cord-333368-kjrk8nn9 143 10 understood understand VBN cord-333368-kjrk8nn9 143 11 regardless regardless RB cord-333368-kjrk8nn9 143 12 of of IN cord-333368-kjrk8nn9 143 13 infection infection NN cord-333368-kjrk8nn9 143 14 119 119 CD cord-333368-kjrk8nn9 143 15 and and CC cord-333368-kjrk8nn9 143 16 the the DT cord-333368-kjrk8nn9 143 17 impact impact NN cord-333368-kjrk8nn9 143 18 of of IN cord-333368-kjrk8nn9 143 19 this this DT cord-333368-kjrk8nn9 143 20 on on IN cord-333368-kjrk8nn9 143 21 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 143 22 needs need NNS cord-333368-kjrk8nn9 143 23 to to TO cord-333368-kjrk8nn9 143 24 be be VB cord-333368-kjrk8nn9 143 25 further further RB cord-333368-kjrk8nn9 143 26 examined examine VBN cord-333368-kjrk8nn9 143 27 . . . cord-333368-kjrk8nn9 144 1 On on IN cord-333368-kjrk8nn9 144 2 the the DT cord-333368-kjrk8nn9 144 3 other other JJ cord-333368-kjrk8nn9 144 4 extreme extreme JJ cord-333368-kjrk8nn9 144 5 , , , cord-333368-kjrk8nn9 144 6 young young JJ cord-333368-kjrk8nn9 144 7 children child NNS cord-333368-kjrk8nn9 144 8 have have VBP cord-333368-kjrk8nn9 144 9 fared fare VBN cord-333368-kjrk8nn9 144 10 better well RBR cord-333368-kjrk8nn9 144 11 than than IN cord-333368-kjrk8nn9 144 12 adults adult NNS cord-333368-kjrk8nn9 144 13 during during IN cord-333368-kjrk8nn9 144 14 this this DT cord-333368-kjrk8nn9 144 15 pandemic pandemic NN cord-333368-kjrk8nn9 144 16 . . . cord-333368-kjrk8nn9 145 1 Many many JJ cord-333368-kjrk8nn9 145 2 viruses virus NNS cord-333368-kjrk8nn9 145 3 , , , cord-333368-kjrk8nn9 145 4 including include VBG cord-333368-kjrk8nn9 145 5 respiratory respiratory JJ cord-333368-kjrk8nn9 145 6 syncytial syncytial JJ cord-333368-kjrk8nn9 145 7 virus virus NN cord-333368-kjrk8nn9 145 8 and and CC cord-333368-kjrk8nn9 145 9 influenza influenza NN cord-333368-kjrk8nn9 145 10 virus virus NN cord-333368-kjrk8nn9 145 11 , , , cord-333368-kjrk8nn9 145 12 infect infect VB cord-333368-kjrk8nn9 145 13 children child NNS cord-333368-kjrk8nn9 145 14 at at IN cord-333368-kjrk8nn9 145 15 particularly particularly RB cord-333368-kjrk8nn9 145 16 high high JJ cord-333368-kjrk8nn9 145 17 rates rate NNS cord-333368-kjrk8nn9 145 18 compared compare VBN cord-333368-kjrk8nn9 145 19 to to IN cord-333368-kjrk8nn9 145 20 adults adult NNS cord-333368-kjrk8nn9 145 21 aged age VBN cord-333368-kjrk8nn9 145 22 30 30 CD cord-333368-kjrk8nn9 145 23 - - SYM cord-333368-kjrk8nn9 145 24 65 65 CD cord-333368-kjrk8nn9 145 25 . . . cord-333368-kjrk8nn9 146 1 However however RB cord-333368-kjrk8nn9 146 2 , , , cord-333368-kjrk8nn9 146 3 children child NNS cord-333368-kjrk8nn9 146 4 appear appear VBP cord-333368-kjrk8nn9 146 5 to to TO cord-333368-kjrk8nn9 146 6 be be VB cord-333368-kjrk8nn9 146 7 less less RBR cord-333368-kjrk8nn9 146 8 susceptible susceptible JJ cord-333368-kjrk8nn9 146 9 to to IN cord-333368-kjrk8nn9 146 10 SARS SARS NNP cord-333368-kjrk8nn9 146 11 , , , cord-333368-kjrk8nn9 146 12 MERS MERS NNP cord-333368-kjrk8nn9 146 13 , , , cord-333368-kjrk8nn9 146 14 and and CC cord-333368-kjrk8nn9 146 15 SARS SARS NNP cord-333368-kjrk8nn9 146 16 - - HYPH cord-333368-kjrk8nn9 146 17 CoV-2 CoV-2 NNP cord-333368-kjrk8nn9 146 18 infection infection NN cord-333368-kjrk8nn9 146 19 120 120 CD cord-333368-kjrk8nn9 146 20 . . . cord-333368-kjrk8nn9 147 1 Additionally additionally RB cord-333368-kjrk8nn9 147 2 , , , cord-333368-kjrk8nn9 147 3 few few JJ cord-333368-kjrk8nn9 147 4 children child NNS cord-333368-kjrk8nn9 147 5 present present JJ cord-333368-kjrk8nn9 147 6 with with IN cord-333368-kjrk8nn9 147 7 common common JJ cord-333368-kjrk8nn9 147 8 co co NNS cord-333368-kjrk8nn9 147 9 - - NNS cord-333368-kjrk8nn9 147 10 morbidities morbidity NNS cord-333368-kjrk8nn9 147 11 seen see VBN cord-333368-kjrk8nn9 147 12 in in IN cord-333368-kjrk8nn9 147 13 adults adult NNS cord-333368-kjrk8nn9 147 14 , , , cord-333368-kjrk8nn9 147 15 such such JJ cord-333368-kjrk8nn9 147 16 as as IN cord-333368-kjrk8nn9 147 17 hypertension hypertension NN cord-333368-kjrk8nn9 147 18 , , , cord-333368-kjrk8nn9 147 19 T2D t2d CD cord-333368-kjrk8nn9 147 20 , , , cord-333368-kjrk8nn9 147 21 cancers cancer NNS cord-333368-kjrk8nn9 147 22 , , , cord-333368-kjrk8nn9 147 23 and and CC cord-333368-kjrk8nn9 147 24 pulmonary pulmonary JJ cord-333368-kjrk8nn9 147 25 diseases disease NNS cord-333368-kjrk8nn9 147 26 . . . cord-333368-kjrk8nn9 148 1 The the DT cord-333368-kjrk8nn9 148 2 absence absence NN cord-333368-kjrk8nn9 148 3 of of IN cord-333368-kjrk8nn9 148 4 these these DT cord-333368-kjrk8nn9 148 5 diseases disease NNS cord-333368-kjrk8nn9 148 6 may may MD cord-333368-kjrk8nn9 148 7 allow allow VB cord-333368-kjrk8nn9 148 8 children child NNS cord-333368-kjrk8nn9 148 9 to to TO cord-333368-kjrk8nn9 148 10 only only RB cord-333368-kjrk8nn9 148 11 have have VB cord-333368-kjrk8nn9 148 12 a a DT cord-333368-kjrk8nn9 148 13 mild mild JJ cord-333368-kjrk8nn9 148 14 case case NN cord-333368-kjrk8nn9 148 15 of of IN cord-333368-kjrk8nn9 148 16 the the DT cord-333368-kjrk8nn9 148 17 virus virus NN cord-333368-kjrk8nn9 148 18 122 122 CD cord-333368-kjrk8nn9 148 19 . . . cord-333368-kjrk8nn9 149 1 More more RBR cord-333368-kjrk8nn9 149 2 recently recently RB cord-333368-kjrk8nn9 149 3 some some DT cord-333368-kjrk8nn9 149 4 children child NNS cord-333368-kjrk8nn9 150 1 A a DT cord-333368-kjrk8nn9 150 2 c c NN cord-333368-kjrk8nn9 150 3 c c NN cord-333368-kjrk8nn9 150 4 e e NN cord-333368-kjrk8nn9 150 5 p p NN cord-333368-kjrk8nn9 150 6 t t NN cord-333368-kjrk8nn9 150 7 e e NN cord-333368-kjrk8nn9 150 8 d d NNP cord-333368-kjrk8nn9 150 9 M M NNP cord-333368-kjrk8nn9 150 10 a a NNP cord-333368-kjrk8nn9 150 11 n n NN cord-333368-kjrk8nn9 150 12 u u NNP cord-333368-kjrk8nn9 150 13 s s NNP cord-333368-kjrk8nn9 150 14 c c NN cord-333368-kjrk8nn9 150 15 r r NN cord-333368-kjrk8nn9 150 16 i i NN cord-333368-kjrk8nn9 150 17 p p NN cord-333368-kjrk8nn9 150 18 t t NN cord-333368-kjrk8nn9 150 19 15 15 CD cord-333368-kjrk8nn9 150 20 who who WP cord-333368-kjrk8nn9 150 21 have have VBP cord-333368-kjrk8nn9 150 22 recovered recover VBN cord-333368-kjrk8nn9 150 23 from from IN cord-333368-kjrk8nn9 150 24 SARS SARS NNP cord-333368-kjrk8nn9 150 25 - - HYPH cord-333368-kjrk8nn9 150 26 CoV-2 CoV-2 NNP cord-333368-kjrk8nn9 150 27 infection infection NN cord-333368-kjrk8nn9 150 28 are be VBP cord-333368-kjrk8nn9 150 29 presenting present VBG cord-333368-kjrk8nn9 150 30 with with IN cord-333368-kjrk8nn9 150 31 post post JJ cord-333368-kjrk8nn9 150 32 - - JJ cord-333368-kjrk8nn9 150 33 infectious infectious JJ cord-333368-kjrk8nn9 150 34 cytokine cytokine NN cord-333368-kjrk8nn9 150 35 release release NN cord-333368-kjrk8nn9 150 36 syndrome syndrome NN cord-333368-kjrk8nn9 150 37 , , , cord-333368-kjrk8nn9 150 38 indicative indicative JJ cord-333368-kjrk8nn9 150 39 by by IN cord-333368-kjrk8nn9 150 40 a a DT cord-333368-kjrk8nn9 150 41 fever fever NN cord-333368-kjrk8nn9 150 42 , , , cord-333368-kjrk8nn9 150 43 GI GI NNP cord-333368-kjrk8nn9 150 44 symptoms symptom NNS cord-333368-kjrk8nn9 150 45 , , , cord-333368-kjrk8nn9 150 46 and and CC cord-333368-kjrk8nn9 150 47 a a DT cord-333368-kjrk8nn9 150 48 rash rash NN cord-333368-kjrk8nn9 150 49 . . . cord-333368-kjrk8nn9 151 1 Consistent consistent JJ cord-333368-kjrk8nn9 151 2 with with IN cord-333368-kjrk8nn9 151 3 early early JJ cord-333368-kjrk8nn9 151 4 life life NN cord-333368-kjrk8nn9 151 5 metainflammation metainflammation NN cord-333368-kjrk8nn9 151 6 with with IN cord-333368-kjrk8nn9 151 7 obesity obesity NN cord-333368-kjrk8nn9 151 8 it -PRON- PRP cord-333368-kjrk8nn9 151 9 appears appear VBZ cord-333368-kjrk8nn9 151 10 that that IN cord-333368-kjrk8nn9 151 11 obese obese JJ cord-333368-kjrk8nn9 151 12 children child NNS cord-333368-kjrk8nn9 151 13 are be VBP cord-333368-kjrk8nn9 151 14 at at IN cord-333368-kjrk8nn9 151 15 higher high JJR cord-333368-kjrk8nn9 151 16 risk risk NN cord-333368-kjrk8nn9 151 17 for for IN cord-333368-kjrk8nn9 151 18 severe severe JJ cord-333368-kjrk8nn9 151 19 disease disease NN cord-333368-kjrk8nn9 151 20 123 123 CD cord-333368-kjrk8nn9 151 21 . . . cord-333368-kjrk8nn9 152 1 Does do VBZ cord-333368-kjrk8nn9 152 2 hyperglycemia hyperglycemia NN cord-333368-kjrk8nn9 152 3 worsen worsen VB cord-333368-kjrk8nn9 152 4 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 152 5 or or CC cord-333368-kjrk8nn9 152 6 does do VBZ cord-333368-kjrk8nn9 152 7 COVID-19 covid-19 VB cord-333368-kjrk8nn9 152 8 lead lead NN cord-333368-kjrk8nn9 152 9 to to IN cord-333368-kjrk8nn9 152 10 immune immune JJ cord-333368-kjrk8nn9 152 11 pancreatic pancreatic JJ cord-333368-kjrk8nn9 152 12 damage damage NN cord-333368-kjrk8nn9 152 13 leading lead VBG cord-333368-kjrk8nn9 152 14 to to IN cord-333368-kjrk8nn9 152 15 hyperglycemia hyperglycemia NN cord-333368-kjrk8nn9 152 16 ? ? . cord-333368-kjrk8nn9 153 1 COVID-19 covid-19 JJ cord-333368-kjrk8nn9 153 2 patients patient NNS cord-333368-kjrk8nn9 153 3 have have VBP cord-333368-kjrk8nn9 153 4 been be VBN cord-333368-kjrk8nn9 153 5 found find VBN cord-333368-kjrk8nn9 153 6 to to TO cord-333368-kjrk8nn9 153 7 have have VB cord-333368-kjrk8nn9 153 8 elevated elevate VBN cord-333368-kjrk8nn9 153 9 blood blood NN cord-333368-kjrk8nn9 153 10 sugars sugar NNS cord-333368-kjrk8nn9 153 11 during during IN cord-333368-kjrk8nn9 153 12 hospitalization hospitalization NN cord-333368-kjrk8nn9 153 13 and and CC cord-333368-kjrk8nn9 153 14 those those DT cord-333368-kjrk8nn9 153 15 with with IN cord-333368-kjrk8nn9 153 16 uncontrolled uncontrolled JJ cord-333368-kjrk8nn9 153 17 diabetes diabetes NN cord-333368-kjrk8nn9 153 18 had have VBD cord-333368-kjrk8nn9 153 19 a a DT cord-333368-kjrk8nn9 153 20 higher high JJR cord-333368-kjrk8nn9 153 21 mortality mortality NN cord-333368-kjrk8nn9 153 22 124 124 CD cord-333368-kjrk8nn9 153 23 . . . cord-333368-kjrk8nn9 154 1 However however RB cord-333368-kjrk8nn9 154 2 , , , cord-333368-kjrk8nn9 154 3 SARS SARS NNP cord-333368-kjrk8nn9 154 4 - - HYPH cord-333368-kjrk8nn9 154 5 CoV-2 CoV-2 NNP cord-333368-kjrk8nn9 154 6 virus virus NN cord-333368-kjrk8nn9 154 7 can can MD cord-333368-kjrk8nn9 154 8 also also RB cord-333368-kjrk8nn9 154 9 damage damage VB cord-333368-kjrk8nn9 154 10 the the DT cord-333368-kjrk8nn9 154 11 pancreas pancrea NNS cord-333368-kjrk8nn9 154 12 by by IN cord-333368-kjrk8nn9 154 13 infecting infect VBG cord-333368-kjrk8nn9 154 14 the the DT cord-333368-kjrk8nn9 154 15   NNP cord-333368-kjrk8nn9 154 16 and and CC cord-333368-kjrk8nn9 154 17   NNP cord-333368-kjrk8nn9 154 18 cells cell NNS cord-333368-kjrk8nn9 154 19 , , , cord-333368-kjrk8nn9 154 20 which which WDT cord-333368-kjrk8nn9 154 21 function function VBP cord-333368-kjrk8nn9 154 22 to to TO cord-333368-kjrk8nn9 154 23 regulate regulate VB cord-333368-kjrk8nn9 154 24 blood blood NN cord-333368-kjrk8nn9 154 25 sugar sugar NN cord-333368-kjrk8nn9 154 26 levels level NNS cord-333368-kjrk8nn9 154 27 . . . cord-333368-kjrk8nn9 155 1 In in IN cord-333368-kjrk8nn9 155 2 severe severe JJ cord-333368-kjrk8nn9 155 3 COVID-19 covid-19 JJ cord-333368-kjrk8nn9 155 4 cases case NNS cord-333368-kjrk8nn9 155 5 , , , cord-333368-kjrk8nn9 155 6 17 17 CD cord-333368-kjrk8nn9 155 7 % % NN cord-333368-kjrk8nn9 155 8 of of IN cord-333368-kjrk8nn9 155 9 patients patient NNS cord-333368-kjrk8nn9 155 10 were be VBD cord-333368-kjrk8nn9 155 11 diagnosed diagnose VBN cord-333368-kjrk8nn9 155 12 with with IN cord-333368-kjrk8nn9 155 13 pancreatic pancreatic JJ cord-333368-kjrk8nn9 155 14 injury injury NN cord-333368-kjrk8nn9 155 15 , , , cord-333368-kjrk8nn9 155 16 compared compare VBN cord-333368-kjrk8nn9 155 17 to to IN cord-333368-kjrk8nn9 155 18 only only RB cord-333368-kjrk8nn9 155 19 1 1 CD cord-333368-kjrk8nn9 155 20 - - SYM cord-333368-kjrk8nn9 155 21 2 2 CD cord-333368-kjrk8nn9 155 22 % % NN cord-333368-kjrk8nn9 155 23 in in IN cord-333368-kjrk8nn9 155 24 non non JJ cord-333368-kjrk8nn9 155 25 - - JJ cord-333368-kjrk8nn9 155 26 severe severe JJ cord-333368-kjrk8nn9 155 27 cases case NNS cord-333368-kjrk8nn9 155 28 125 125 CD cord-333368-kjrk8nn9 155 29 . . . cord-333368-kjrk8nn9 156 1 One one CD cord-333368-kjrk8nn9 156 2 possible possible JJ cord-333368-kjrk8nn9 156 3 explanation explanation NN cord-333368-kjrk8nn9 156 4 is be VBZ cord-333368-kjrk8nn9 156 5 that that IN cord-333368-kjrk8nn9 156 6 the the DT cord-333368-kjrk8nn9 156 7 virus virus NN cord-333368-kjrk8nn9 156 8 can can MD cord-333368-kjrk8nn9 156 9 also also RB cord-333368-kjrk8nn9 156 10 increase increase VB cord-333368-kjrk8nn9 156 11 pro pro JJ cord-333368-kjrk8nn9 156 12 - - JJ cord-333368-kjrk8nn9 156 13 inflammatory inflammatory JJ cord-333368-kjrk8nn9 156 14 cytokines cytokine NNS cord-333368-kjrk8nn9 156 15 that that WDT cord-333368-kjrk8nn9 156 16 destroy destroy VBP cord-333368-kjrk8nn9 156 17 these these DT cord-333368-kjrk8nn9 156 18 cells cell NNS cord-333368-kjrk8nn9 156 19 . . . cord-333368-kjrk8nn9 157 1 This this DT cord-333368-kjrk8nn9 157 2 could could MD cord-333368-kjrk8nn9 157 3 possibly possibly RB cord-333368-kjrk8nn9 157 4 lead lead VB cord-333368-kjrk8nn9 157 5 to to IN cord-333368-kjrk8nn9 157 6 an an DT cord-333368-kjrk8nn9 157 7 autoimmune autoimmune JJ cord-333368-kjrk8nn9 157 8 disease disease NN cord-333368-kjrk8nn9 157 9 and and CC cord-333368-kjrk8nn9 157 10 development development NN cord-333368-kjrk8nn9 157 11 of of IN cord-333368-kjrk8nn9 157 12 type type NN cord-333368-kjrk8nn9 157 13 1 1 CD cord-333368-kjrk8nn9 157 14 diabetes diabetes NN cord-333368-kjrk8nn9 157 15 ( ( -LRB- cord-333368-kjrk8nn9 157 16 T1D t1d LS cord-333368-kjrk8nn9 157 17 ) ) -RRB- cord-333368-kjrk8nn9 157 18 126 126 CD cord-333368-kjrk8nn9 157 19 . . . cord-333368-kjrk8nn9 158 1 Prior prior JJ cord-333368-kjrk8nn9 158 2 studies study NNS cord-333368-kjrk8nn9 158 3 have have VBP cord-333368-kjrk8nn9 158 4 demonstrated demonstrate VBN cord-333368-kjrk8nn9 158 5 that that IN cord-333368-kjrk8nn9 158 6 SARS SARS NNP cord-333368-kjrk8nn9 158 7 coronavirus coronavirus NN cord-333368-kjrk8nn9 158 8 itself -PRON- PRP cord-333368-kjrk8nn9 158 9 can can MD cord-333368-kjrk8nn9 158 10 directly directly RB cord-333368-kjrk8nn9 158 11 damage damage VB cord-333368-kjrk8nn9 158 12 islets islet NNS cord-333368-kjrk8nn9 158 13 127 127 CD cord-333368-kjrk8nn9 158 14 , , , cord-333368-kjrk8nn9 158 15 further further JJ cord-333368-kjrk8nn9 158 16 research research NN cord-333368-kjrk8nn9 158 17 will will MD cord-333368-kjrk8nn9 158 18 be be VB cord-333368-kjrk8nn9 158 19 needed need VBN cord-333368-kjrk8nn9 158 20 to to TO cord-333368-kjrk8nn9 158 21 see see VB cord-333368-kjrk8nn9 158 22 if if IN cord-333368-kjrk8nn9 158 23 T1D t1d NN cord-333368-kjrk8nn9 158 24 or or CC cord-333368-kjrk8nn9 158 25 beta beta JJ cord-333368-kjrk8nn9 158 26 cell cell NN cord-333368-kjrk8nn9 158 27 failures failure NNS cord-333368-kjrk8nn9 158 28 were be VBD cord-333368-kjrk8nn9 158 29 caused cause VBN cord-333368-kjrk8nn9 158 30 by by IN cord-333368-kjrk8nn9 158 31 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 158 32 and and CC cord-333368-kjrk8nn9 158 33 if if IN cord-333368-kjrk8nn9 158 34 this this DT cord-333368-kjrk8nn9 158 35 has have VBZ cord-333368-kjrk8nn9 158 36 happened happen VBN cord-333368-kjrk8nn9 158 37 to to IN cord-333368-kjrk8nn9 158 38 other other JJ cord-333368-kjrk8nn9 158 39 individuals individual NNS cord-333368-kjrk8nn9 158 40 128 128 CD cord-333368-kjrk8nn9 158 41 . . . cord-333368-kjrk8nn9 159 1 Given give VBN cord-333368-kjrk8nn9 159 2 ACE-2 ACE-2 NNP cord-333368-kjrk8nn9 159 3 expression expression NN cord-333368-kjrk8nn9 159 4 in in IN cord-333368-kjrk8nn9 159 5 the the DT cord-333368-kjrk8nn9 159 6 pancreas pancreas NN cord-333368-kjrk8nn9 159 7 it -PRON- PRP cord-333368-kjrk8nn9 159 8 has have VBZ cord-333368-kjrk8nn9 159 9 been be VBN cord-333368-kjrk8nn9 159 10 hypothesized hypothesize VBN cord-333368-kjrk8nn9 159 11 that that IN cord-333368-kjrk8nn9 159 12 this this DT cord-333368-kjrk8nn9 159 13 may may MD cord-333368-kjrk8nn9 159 14 be be VB cord-333368-kjrk8nn9 159 15 a a DT cord-333368-kjrk8nn9 159 16 mechanism mechanism NN cord-333368-kjrk8nn9 159 17 for for IN cord-333368-kjrk8nn9 159 18 pancreatic pancreatic JJ cord-333368-kjrk8nn9 159 19 damage damage NN cord-333368-kjrk8nn9 159 20 specifically specifically RB cord-333368-kjrk8nn9 159 21 in in IN cord-333368-kjrk8nn9 159 22 SARS SARS NNP cord-333368-kjrk8nn9 159 23 - - HYPH cord-333368-kjrk8nn9 159 24 Cov2 Cov2 NNP cord-333368-kjrk8nn9 159 25 infection infection NN cord-333368-kjrk8nn9 159 26 127 127 CD cord-333368-kjrk8nn9 159 27 . . . cord-333368-kjrk8nn9 160 1 Obesity obesity NN cord-333368-kjrk8nn9 160 2 is be VBZ cord-333368-kjrk8nn9 160 3 a a DT cord-333368-kjrk8nn9 160 4 significant significant JJ cord-333368-kjrk8nn9 160 5 risk risk NN cord-333368-kjrk8nn9 160 6 factor factor NN cord-333368-kjrk8nn9 160 7 for for IN cord-333368-kjrk8nn9 160 8 severe severe JJ cord-333368-kjrk8nn9 160 9 COVID-19 covid-19 JJ cord-333368-kjrk8nn9 160 10 illness illness NN cord-333368-kjrk8nn9 160 11 . . . cord-333368-kjrk8nn9 161 1 Patients patient NNS cord-333368-kjrk8nn9 161 2 with with IN cord-333368-kjrk8nn9 161 3 obesity obesity NN cord-333368-kjrk8nn9 161 4 and and CC cord-333368-kjrk8nn9 161 5 metabolic metabolic JJ cord-333368-kjrk8nn9 161 6 disease disease NN cord-333368-kjrk8nn9 161 7 frequently frequently RB cord-333368-kjrk8nn9 161 8 experience experience VBP cord-333368-kjrk8nn9 161 9 a a DT cord-333368-kjrk8nn9 161 10 state state NN cord-333368-kjrk8nn9 161 11 of of IN cord-333368-kjrk8nn9 161 12 low low JJ cord-333368-kjrk8nn9 161 13 - - HYPH cord-333368-kjrk8nn9 161 14 grade grade NN cord-333368-kjrk8nn9 161 15 chronic chronic JJ cord-333368-kjrk8nn9 161 16 meta meta NN cord-333368-kjrk8nn9 161 17 - - HYPH cord-333368-kjrk8nn9 161 18 inflammation inflammation NN cord-333368-kjrk8nn9 161 19 . . . cord-333368-kjrk8nn9 162 1 Prior prior JJ cord-333368-kjrk8nn9 162 2 studies study NNS cord-333368-kjrk8nn9 162 3 of of IN cord-333368-kjrk8nn9 162 4 vaccine vaccine NN cord-333368-kjrk8nn9 162 5 efficacy efficacy NN cord-333368-kjrk8nn9 162 6 and and CC cord-333368-kjrk8nn9 162 7 response response NN cord-333368-kjrk8nn9 162 8 to to IN cord-333368-kjrk8nn9 162 9 viral viral JJ cord-333368-kjrk8nn9 162 10 and and CC cord-333368-kjrk8nn9 162 11 bacterial bacterial JJ cord-333368-kjrk8nn9 162 12 infection infection NN cord-333368-kjrk8nn9 162 13 show show VBP cord-333368-kjrk8nn9 162 14 that that IN cord-333368-kjrk8nn9 162 15 meta meta NN cord-333368-kjrk8nn9 162 16 - - HYPH cord-333368-kjrk8nn9 162 17 inflammation inflammation NN cord-333368-kjrk8nn9 162 18 may may MD cord-333368-kjrk8nn9 162 19 significantly significantly RB cord-333368-kjrk8nn9 162 20 alter alter VB cord-333368-kjrk8nn9 162 21 the the DT cord-333368-kjrk8nn9 162 22 response response NN cord-333368-kjrk8nn9 162 23 to to IN cord-333368-kjrk8nn9 162 24 pathogens pathogen NNS cord-333368-kjrk8nn9 162 25 . . . cord-333368-kjrk8nn9 163 1 While while IN cord-333368-kjrk8nn9 163 2 this this DT cord-333368-kjrk8nn9 163 3 has have VBZ cord-333368-kjrk8nn9 163 4 not not RB cord-333368-kjrk8nn9 163 5 been be VBN cord-333368-kjrk8nn9 163 6 directly directly RB cord-333368-kjrk8nn9 163 7 established establish VBN cord-333368-kjrk8nn9 163 8 in in IN cord-333368-kjrk8nn9 163 9 SARS SARS NNP cord-333368-kjrk8nn9 163 10 - - HYPH cord-333368-kjrk8nn9 163 11 CoV-2 CoV-2 NNP cord-333368-kjrk8nn9 163 12 infection infection NN cord-333368-kjrk8nn9 163 13 , , , cord-333368-kjrk8nn9 163 14 emerging emerge VBG cord-333368-kjrk8nn9 163 15 evidence evidence NN cord-333368-kjrk8nn9 163 16 indicates indicate VBZ cord-333368-kjrk8nn9 163 17 that that IN cord-333368-kjrk8nn9 163 18 disordered disordered JJ cord-333368-kjrk8nn9 163 19 myeloid myeloid JJ cord-333368-kjrk8nn9 163 20 inflammatory inflammatory JJ cord-333368-kjrk8nn9 163 21 responses response NNS cord-333368-kjrk8nn9 163 22 are be VBP cord-333368-kjrk8nn9 163 23 a a DT cord-333368-kjrk8nn9 163 24 A a NN cord-333368-kjrk8nn9 163 25 c c NN cord-333368-kjrk8nn9 163 26 c c NN cord-333368-kjrk8nn9 163 27 e e NN cord-333368-kjrk8nn9 163 28 p p NN cord-333368-kjrk8nn9 163 29 t t NN cord-333368-kjrk8nn9 163 30 e e NN cord-333368-kjrk8nn9 163 31 d d NNP cord-333368-kjrk8nn9 163 32 M M NNP cord-333368-kjrk8nn9 163 33 a a NNP cord-333368-kjrk8nn9 163 34 n n NN cord-333368-kjrk8nn9 163 35 u u NNP cord-333368-kjrk8nn9 163 36 s s NNP cord-333368-kjrk8nn9 163 37 c c NN cord-333368-kjrk8nn9 163 38 r r NN cord-333368-kjrk8nn9 163 39 i i NN cord-333368-kjrk8nn9 163 40 p p NN cord-333368-kjrk8nn9 163 41 t t NNP cord-333368-kjrk8nn9 163 42 Clinical Clinical NNP cord-333368-kjrk8nn9 163 43 Characteristics Characteristics NNPS cord-333368-kjrk8nn9 163 44 and and CC cord-333368-kjrk8nn9 163 45 Morbidity morbidity NN cord-333368-kjrk8nn9 163 46 Associated Associated NNP cord-333368-kjrk8nn9 163 47 With with IN cord-333368-kjrk8nn9 163 48 Coronavirus Coronavirus NNP cord-333368-kjrk8nn9 163 49 Disease Disease NNP cord-333368-kjrk8nn9 163 50 2019 2019 CD cord-333368-kjrk8nn9 163 51 in in IN cord-333368-kjrk8nn9 163 52 a a DT cord-333368-kjrk8nn9 163 53 Series Series NNP cord-333368-kjrk8nn9 163 54 of of IN cord-333368-kjrk8nn9 163 55 Patients Patients NNP cord-333368-kjrk8nn9 163 56 in in IN cord-333368-kjrk8nn9 163 57 Metropolitan Metropolitan NNP cord-333368-kjrk8nn9 163 58 Detroit Detroit NNP cord-333368-kjrk8nn9 163 59 Characteristics Characteristics NNP cord-333368-kjrk8nn9 163 60 Associated Associated NNP cord-333368-kjrk8nn9 163 61 with with IN cord-333368-kjrk8nn9 163 62 Hospitalization hospitalization NN cord-333368-kjrk8nn9 164 1 Among among IN cord-333368-kjrk8nn9 164 2 Patients patient NNS cord-333368-kjrk8nn9 164 3 with with IN cord-333368-kjrk8nn9 164 4 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 164 5 Overweight overweight JJ cord-333368-kjrk8nn9 164 6 or or CC cord-333368-kjrk8nn9 164 7 obese obese JJ cord-333368-kjrk8nn9 164 8 BMI BMI NNP cord-333368-kjrk8nn9 164 9 is be VBZ cord-333368-kjrk8nn9 164 10 associated associate VBN cord-333368-kjrk8nn9 164 11 with with IN cord-333368-kjrk8nn9 164 12 earlier early RBR cord-333368-kjrk8nn9 164 13 , , , cord-333368-kjrk8nn9 164 14 but but CC cord-333368-kjrk8nn9 164 15 not not RB cord-333368-kjrk8nn9 164 16 later later RB cord-333368-kjrk8nn9 164 17 survival survival NN cord-333368-kjrk8nn9 164 18 after after IN cord-333368-kjrk8nn9 164 19 common common JJ cord-333368-kjrk8nn9 164 20 acute acute JJ cord-333368-kjrk8nn9 164 21 illnesses illness NNS cord-333368-kjrk8nn9 164 22 Obesity obesity NN cord-333368-kjrk8nn9 164 23 and and CC cord-333368-kjrk8nn9 164 24 1-year 1-year CD cord-333368-kjrk8nn9 164 25 outcomes outcome NNS cord-333368-kjrk8nn9 164 26 in in IN cord-333368-kjrk8nn9 164 27 older old JJR cord-333368-kjrk8nn9 164 28 Americans Americans NNPS cord-333368-kjrk8nn9 164 29 with with IN cord-333368-kjrk8nn9 164 30 severe severe JJ cord-333368-kjrk8nn9 164 31 sepsis sepsis NN cord-333368-kjrk8nn9 164 32 Association Association NNP cord-333368-kjrk8nn9 164 33 of of IN cord-333368-kjrk8nn9 164 34 Blood Blood NNP cord-333368-kjrk8nn9 164 35 Glucose Glucose NNP cord-333368-kjrk8nn9 164 36 Control Control NNP cord-333368-kjrk8nn9 164 37 and and CC cord-333368-kjrk8nn9 164 38 Outcomes Outcomes NNPS cord-333368-kjrk8nn9 164 39 in in IN cord-333368-kjrk8nn9 164 40 Patients patient NNS cord-333368-kjrk8nn9 164 41 with with IN cord-333368-kjrk8nn9 164 42 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 164 43 and and CC cord-333368-kjrk8nn9 164 44 Pre pre JJ cord-333368-kjrk8nn9 164 45 - - JJ cord-333368-kjrk8nn9 164 46 existing existing JJ cord-333368-kjrk8nn9 164 47 Type type NN cord-333368-kjrk8nn9 164 48 2 2 CD cord-333368-kjrk8nn9 164 49 Diabetes Diabetes NNP cord-333368-kjrk8nn9 164 50 Clinical clinical JJ cord-333368-kjrk8nn9 164 51 Characteristics characteristic NNS cord-333368-kjrk8nn9 164 52 of of IN cord-333368-kjrk8nn9 164 53 Covid-19 covid-19 NN cord-333368-kjrk8nn9 164 54 in in IN cord-333368-kjrk8nn9 164 55 New New NNP cord-333368-kjrk8nn9 164 56 York York NNP cord-333368-kjrk8nn9 164 57 City City NNP cord-333368-kjrk8nn9 164 58 Epidemiology Epidemiology NNP cord-333368-kjrk8nn9 164 59 , , , cord-333368-kjrk8nn9 164 60 clinical clinical JJ cord-333368-kjrk8nn9 164 61 course course NN cord-333368-kjrk8nn9 164 62 , , , cord-333368-kjrk8nn9 164 63 and and CC cord-333368-kjrk8nn9 164 64 outcomes outcome NNS cord-333368-kjrk8nn9 164 65 of of IN cord-333368-kjrk8nn9 164 66 critically critically RB cord-333368-kjrk8nn9 164 67 ill ill JJ cord-333368-kjrk8nn9 164 68 adults adult NNS cord-333368-kjrk8nn9 164 69 with with IN cord-333368-kjrk8nn9 164 70 COVID-19 covid-19 CD cord-333368-kjrk8nn9 164 71 in in IN cord-333368-kjrk8nn9 164 72 New New NNP cord-333368-kjrk8nn9 164 73 York York NNP cord-333368-kjrk8nn9 164 74 City City NNP cord-333368-kjrk8nn9 164 75 : : : cord-333368-kjrk8nn9 164 76 a a DT cord-333368-kjrk8nn9 164 77 prospective prospective JJ cord-333368-kjrk8nn9 164 78 cohort cohort NN cord-333368-kjrk8nn9 164 79 study study NN cord-333368-kjrk8nn9 164 80 Presenting Presenting NNP cord-333368-kjrk8nn9 164 81 Characteristics Characteristics NNP cord-333368-kjrk8nn9 164 82 , , , cord-333368-kjrk8nn9 164 83 Comorbidities Comorbidities NNPS cord-333368-kjrk8nn9 164 84 , , , cord-333368-kjrk8nn9 164 85 and and CC cord-333368-kjrk8nn9 164 86 Outcomes outcome NNS cord-333368-kjrk8nn9 165 1 Among among IN cord-333368-kjrk8nn9 165 2 5700 5700 CD cord-333368-kjrk8nn9 165 3 Patients patient NNS cord-333368-kjrk8nn9 165 4 Hospitalized hospitalize VBN cord-333368-kjrk8nn9 165 5 With with IN cord-333368-kjrk8nn9 165 6 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 165 7 in in IN cord-333368-kjrk8nn9 165 8 the the DT cord-333368-kjrk8nn9 165 9 New New NNP cord-333368-kjrk8nn9 165 10 York York NNP cord-333368-kjrk8nn9 165 11 City City NNP cord-333368-kjrk8nn9 165 12 Area Area NNP cord-333368-kjrk8nn9 166 1 The the DT cord-333368-kjrk8nn9 166 2 obesity obesity NN cord-333368-kjrk8nn9 166 3 transition transition NN cord-333368-kjrk8nn9 166 4 : : : cord-333368-kjrk8nn9 166 5 stages stage NNS cord-333368-kjrk8nn9 166 6 of of IN cord-333368-kjrk8nn9 166 7 the the DT cord-333368-kjrk8nn9 166 8 global global JJ cord-333368-kjrk8nn9 166 9 epidemic epidemic NN cord-333368-kjrk8nn9 167 1 Obesity obesity NN cord-333368-kjrk8nn9 167 2 could could MD cord-333368-kjrk8nn9 167 3 shift shift VB cord-333368-kjrk8nn9 167 4 severe severe JJ cord-333368-kjrk8nn9 167 5 COVID-19 covid-19 JJ cord-333368-kjrk8nn9 167 6 disease disease NN cord-333368-kjrk8nn9 167 7 to to IN cord-333368-kjrk8nn9 167 8 younger young JJR cord-333368-kjrk8nn9 167 9 ages age NNS cord-333368-kjrk8nn9 167 10 Obesity obesity NN cord-333368-kjrk8nn9 167 11 and and CC cord-333368-kjrk8nn9 167 12 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 167 13 in in IN cord-333368-kjrk8nn9 167 14 New New NNP cord-333368-kjrk8nn9 167 15 York York NNP cord-333368-kjrk8nn9 167 16 City City NNP cord-333368-kjrk8nn9 167 17 : : : cord-333368-kjrk8nn9 168 1 A a DT cord-333368-kjrk8nn9 168 2 Retrospective Retrospective NNP cord-333368-kjrk8nn9 168 3 Cohort Cohort NNP cord-333368-kjrk8nn9 168 4 Study Study NNP cord-333368-kjrk8nn9 168 5 Obesity Obesity NNP cord-333368-kjrk8nn9 168 6 is be VBZ cord-333368-kjrk8nn9 168 7 associated associate VBN cord-333368-kjrk8nn9 168 8 with with IN cord-333368-kjrk8nn9 168 9 worse bad JJR cord-333368-kjrk8nn9 168 10 outcomes outcome NNS cord-333368-kjrk8nn9 168 11 in in IN cord-333368-kjrk8nn9 168 12 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 168 13 : : : cord-333368-kjrk8nn9 168 14 Analysis analysis NN cord-333368-kjrk8nn9 168 15 of of IN cord-333368-kjrk8nn9 168 16 Early Early NNP cord-333368-kjrk8nn9 168 17 Data Data NNP cord-333368-kjrk8nn9 168 18 From from IN cord-333368-kjrk8nn9 168 19 Obesity obesity NN cord-333368-kjrk8nn9 168 20 is be VBZ cord-333368-kjrk8nn9 168 21 Associated associate VBN cord-333368-kjrk8nn9 168 22 with with IN cord-333368-kjrk8nn9 168 23 Increased Increased NNP cord-333368-kjrk8nn9 168 24 Risk Risk NNP cord-333368-kjrk8nn9 168 25 for for IN cord-333368-kjrk8nn9 168 26 Mortality mortality NN cord-333368-kjrk8nn9 169 1 Among among IN cord-333368-kjrk8nn9 169 2 Hospitalized Hospitalized NNP cord-333368-kjrk8nn9 169 3 Patients Patients NNP cord-333368-kjrk8nn9 169 4 with with IN cord-333368-kjrk8nn9 169 5 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 169 6 Severe severe JJ cord-333368-kjrk8nn9 169 7 obesity obesity NN cord-333368-kjrk8nn9 169 8 , , , cord-333368-kjrk8nn9 169 9 increasing increase VBG cord-333368-kjrk8nn9 169 10 age age NN cord-333368-kjrk8nn9 169 11 and and CC cord-333368-kjrk8nn9 169 12 male male JJ cord-333368-kjrk8nn9 169 13 sex sex NN cord-333368-kjrk8nn9 169 14 are be VBP cord-333368-kjrk8nn9 169 15 independently independently RB cord-333368-kjrk8nn9 169 16 associated associate VBN cord-333368-kjrk8nn9 169 17 with with IN cord-333368-kjrk8nn9 169 18 worse bad JJR cord-333368-kjrk8nn9 169 19 in in IN cord-333368-kjrk8nn9 169 20 - - HYPH cord-333368-kjrk8nn9 169 21 hospital hospital NN cord-333368-kjrk8nn9 169 22 outcomes outcome NNS cord-333368-kjrk8nn9 169 23 , , , cord-333368-kjrk8nn9 169 24 and and CC cord-333368-kjrk8nn9 169 25 higher high JJR cord-333368-kjrk8nn9 169 26 in in IN cord-333368-kjrk8nn9 169 27 - - HYPH cord-333368-kjrk8nn9 169 28 hospital hospital NN cord-333368-kjrk8nn9 169 29 mortality mortality NN cord-333368-kjrk8nn9 169 30 Obesity obesity NN cord-333368-kjrk8nn9 169 31 as as IN cord-333368-kjrk8nn9 169 32 a a DT cord-333368-kjrk8nn9 169 33 Potential Potential NNP cord-333368-kjrk8nn9 169 34 Predictor Predictor NNP cord-333368-kjrk8nn9 169 35 of of IN cord-333368-kjrk8nn9 169 36 Disease Disease NNP cord-333368-kjrk8nn9 169 37 Severity Severity NNP cord-333368-kjrk8nn9 169 38 in in IN cord-333368-kjrk8nn9 169 39 Young Young NNP cord-333368-kjrk8nn9 169 40 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 169 41 Patients Patients NNPS cord-333368-kjrk8nn9 169 42 : : : cord-333368-kjrk8nn9 169 43 A a DT cord-333368-kjrk8nn9 169 44 Retrospective Retrospective NNP cord-333368-kjrk8nn9 169 45 Study study NN cord-333368-kjrk8nn9 169 46 Morbid Morbid NNP cord-333368-kjrk8nn9 169 47 Obesity Obesity NNP cord-333368-kjrk8nn9 169 48 as as IN cord-333368-kjrk8nn9 169 49 an an DT cord-333368-kjrk8nn9 169 50 Independent Independent NNP cord-333368-kjrk8nn9 169 51 Risk Risk NNP cord-333368-kjrk8nn9 169 52 Factor Factor NNP cord-333368-kjrk8nn9 169 53 for for IN cord-333368-kjrk8nn9 169 54 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 169 55 Mortality Mortality NNP cord-333368-kjrk8nn9 169 56 in in IN cord-333368-kjrk8nn9 169 57 Hospitalized Hospitalized NNP cord-333368-kjrk8nn9 169 58 Patients Patients NNPS cord-333368-kjrk8nn9 169 59 Younger young JJR cord-333368-kjrk8nn9 169 60 than than IN cord-333368-kjrk8nn9 169 61 50 50 CD cord-333368-kjrk8nn9 169 62 OpenSAFELY OpenSAFELY NNP cord-333368-kjrk8nn9 169 63 : : : cord-333368-kjrk8nn9 170 1 factors factor NNS cord-333368-kjrk8nn9 170 2 associated associate VBN cord-333368-kjrk8nn9 170 3 with with IN cord-333368-kjrk8nn9 170 4 COVID-19 covid-19 JJ cord-333368-kjrk8nn9 170 5 death death NN cord-333368-kjrk8nn9 170 6 in in IN cord-333368-kjrk8nn9 170 7 17 17 CD cord-333368-kjrk8nn9 170 8 million million CD cord-333368-kjrk8nn9 170 9 patients patient NNS cord-333368-kjrk8nn9 170 10 Can Can MD cord-333368-kjrk8nn9 170 11 body body VB cord-333368-kjrk8nn9 170 12 mass mass NN cord-333368-kjrk8nn9 170 13 index index NN cord-333368-kjrk8nn9 170 14 predict predict VB cord-333368-kjrk8nn9 170 15 clinical clinical JJ cord-333368-kjrk8nn9 170 16 outcomes outcome NNS cord-333368-kjrk8nn9 170 17 for for IN cord-333368-kjrk8nn9 170 18 patients patient NNS cord-333368-kjrk8nn9 170 19 with with IN cord-333368-kjrk8nn9 170 20 acute acute JJ cord-333368-kjrk8nn9 170 21 lung lung NN cord-333368-kjrk8nn9 170 22 injury injury NN cord-333368-kjrk8nn9 170 23 / / SYM cord-333368-kjrk8nn9 170 24 acute acute JJ cord-333368-kjrk8nn9 170 25 respiratory respiratory JJ cord-333368-kjrk8nn9 170 26 distress distress NN cord-333368-kjrk8nn9 170 27 syndrome syndrome NN cord-333368-kjrk8nn9 170 28 ? ? . cord-333368-kjrk8nn9 171 1 A a DT cord-333368-kjrk8nn9 171 2 meta meta JJ cord-333368-kjrk8nn9 171 3 - - HYPH cord-333368-kjrk8nn9 171 4 analysis analysis NN cord-333368-kjrk8nn9 172 1 The the DT cord-333368-kjrk8nn9 172 2 role role NN cord-333368-kjrk8nn9 172 3 of of IN cord-333368-kjrk8nn9 172 4 increased increase VBN cord-333368-kjrk8nn9 172 5 body body NN cord-333368-kjrk8nn9 172 6 mass mass NN cord-333368-kjrk8nn9 172 7 index index NN cord-333368-kjrk8nn9 172 8 in in IN cord-333368-kjrk8nn9 172 9 outcomes outcome NNS cord-333368-kjrk8nn9 172 10 of of IN cord-333368-kjrk8nn9 172 11 sepsis sepsis NN cord-333368-kjrk8nn9 172 12 : : : cord-333368-kjrk8nn9 172 13 a a DT cord-333368-kjrk8nn9 172 14 systematic systematic JJ cord-333368-kjrk8nn9 172 15 review review NN cord-333368-kjrk8nn9 172 16 and and CC cord-333368-kjrk8nn9 172 17 meta meta NN cord-333368-kjrk8nn9 172 18 - - HYPH cord-333368-kjrk8nn9 172 19 analysis analysis NN cord-333368-kjrk8nn9 172 20 Body Body NNP cord-333368-kjrk8nn9 172 21 Habitus Habitus NNP cord-333368-kjrk8nn9 172 22 and and CC cord-333368-kjrk8nn9 172 23 Risk Risk NNP cord-333368-kjrk8nn9 172 24 of of IN cord-333368-kjrk8nn9 172 25 Mortality Mortality NNP cord-333368-kjrk8nn9 172 26 in in IN cord-333368-kjrk8nn9 172 27 Pediatric Pediatric NNP cord-333368-kjrk8nn9 172 28 Sepsis Sepsis NNP cord-333368-kjrk8nn9 172 29 and and CC cord-333368-kjrk8nn9 172 30 Septic Septic NNP cord-333368-kjrk8nn9 172 31 Shock Shock NNP cord-333368-kjrk8nn9 172 32 : : : cord-333368-kjrk8nn9 172 33 A a DT cord-333368-kjrk8nn9 172 34 Retrospective Retrospective NNP cord-333368-kjrk8nn9 172 35 Cohort Cohort NNP cord-333368-kjrk8nn9 172 36 Study Study NNP cord-333368-kjrk8nn9 172 37 Outcomes Outcomes NNPS cord-333368-kjrk8nn9 172 38 and and CC cord-333368-kjrk8nn9 172 39 Resource resource NN cord-333368-kjrk8nn9 172 40 Use use NN cord-333368-kjrk8nn9 173 1 Among among IN cord-333368-kjrk8nn9 173 2 Overweight overweight JJ cord-333368-kjrk8nn9 173 3 and and CC cord-333368-kjrk8nn9 173 4 Obese obese JJ cord-333368-kjrk8nn9 173 5 Children child NNS cord-333368-kjrk8nn9 173 6 With with IN cord-333368-kjrk8nn9 173 7 Sepsis sepsis NN cord-333368-kjrk8nn9 173 8 in in IN cord-333368-kjrk8nn9 173 9 the the DT cord-333368-kjrk8nn9 173 10 Pediatric Pediatric NNP cord-333368-kjrk8nn9 173 11 Intensive Intensive NNP cord-333368-kjrk8nn9 173 12 Care Care NNP cord-333368-kjrk8nn9 173 13 Unit Unit NNP cord-333368-kjrk8nn9 173 14 Influence influence NN cord-333368-kjrk8nn9 173 15 of of IN cord-333368-kjrk8nn9 173 16 Obesity obesity NN cord-333368-kjrk8nn9 173 17 Diagnosis Diagnosis NNP cord-333368-kjrk8nn9 173 18 With with IN cord-333368-kjrk8nn9 173 19 Organ Organ NNP cord-333368-kjrk8nn9 173 20 Dysfunction Dysfunction NNP cord-333368-kjrk8nn9 173 21 , , , cord-333368-kjrk8nn9 173 22 Mortality mortality NN cord-333368-kjrk8nn9 173 23 , , , cord-333368-kjrk8nn9 173 24 and and CC cord-333368-kjrk8nn9 173 25 Resource resource NN cord-333368-kjrk8nn9 173 26 Use use NN cord-333368-kjrk8nn9 174 1 Among among IN cord-333368-kjrk8nn9 174 2 Children child NNS cord-333368-kjrk8nn9 174 3 Hospitalized hospitalize VBN cord-333368-kjrk8nn9 174 4 With with IN cord-333368-kjrk8nn9 174 5 Infection infection NN cord-333368-kjrk8nn9 174 6 in in IN cord-333368-kjrk8nn9 174 7 the the DT cord-333368-kjrk8nn9 174 8 United United NNP cord-333368-kjrk8nn9 174 9 States States NNP cord-333368-kjrk8nn9 175 1 The the DT cord-333368-kjrk8nn9 175 2 Role role NN cord-333368-kjrk8nn9 175 3 of of IN cord-333368-kjrk8nn9 175 4 Obesity obesity NN cord-333368-kjrk8nn9 175 5 in in IN cord-333368-kjrk8nn9 175 6 Sepsis sepsis NN cord-333368-kjrk8nn9 175 7 Outcome outcome NN cord-333368-kjrk8nn9 175 8 among among IN cord-333368-kjrk8nn9 175 9 Critically critically RB cord-333368-kjrk8nn9 175 10 Ill Ill NNP cord-333368-kjrk8nn9 175 11 Patients patient NNS cord-333368-kjrk8nn9 175 12 : : : cord-333368-kjrk8nn9 176 1 A a DT cord-333368-kjrk8nn9 176 2 Retrospective Retrospective NNP cord-333368-kjrk8nn9 176 3 Cohort Cohort NNP cord-333368-kjrk8nn9 176 4 Analysis Analysis NNP cord-333368-kjrk8nn9 176 5 Underweight Underweight NNP cord-333368-kjrk8nn9 176 6 , , , cord-333368-kjrk8nn9 176 7 overweight overweight JJ cord-333368-kjrk8nn9 176 8 , , , cord-333368-kjrk8nn9 176 9 and and CC cord-333368-kjrk8nn9 176 10 obesity obesity NN cord-333368-kjrk8nn9 176 11 as as IN cord-333368-kjrk8nn9 176 12 independent independent JJ cord-333368-kjrk8nn9 176 13 risk risk NN cord-333368-kjrk8nn9 176 14 factors factor NNS cord-333368-kjrk8nn9 176 15 for for IN cord-333368-kjrk8nn9 176 16 hospitalization hospitalization NN cord-333368-kjrk8nn9 176 17 in in IN cord-333368-kjrk8nn9 176 18 adults adult NNS cord-333368-kjrk8nn9 176 19 and and CC cord-333368-kjrk8nn9 176 20 children child NNS cord-333368-kjrk8nn9 176 21 from from IN cord-333368-kjrk8nn9 176 22 influenza influenza NN cord-333368-kjrk8nn9 176 23 and and CC cord-333368-kjrk8nn9 176 24 other other JJ cord-333368-kjrk8nn9 176 25 respiratory respiratory JJ cord-333368-kjrk8nn9 176 26 viruses virus NNS cord-333368-kjrk8nn9 176 27 Increased increase VBN cord-333368-kjrk8nn9 176 28 risk risk NN cord-333368-kjrk8nn9 176 29 of of IN cord-333368-kjrk8nn9 176 30 influenza influenza NN cord-333368-kjrk8nn9 176 31 among among IN cord-333368-kjrk8nn9 176 32 vaccinated vaccinated JJ cord-333368-kjrk8nn9 176 33 adults adult NNS cord-333368-kjrk8nn9 176 34 who who WP cord-333368-kjrk8nn9 176 35 are be VBP cord-333368-kjrk8nn9 176 36 obese obese JJ cord-333368-kjrk8nn9 176 37 Impact impact NN cord-333368-kjrk8nn9 176 38 of of IN cord-333368-kjrk8nn9 176 39 obesity obesity NN cord-333368-kjrk8nn9 176 40 on on IN cord-333368-kjrk8nn9 176 41 sepsis sepsis NN cord-333368-kjrk8nn9 176 42 mortality mortality NN cord-333368-kjrk8nn9 176 43 : : : cord-333368-kjrk8nn9 177 1 A a DT cord-333368-kjrk8nn9 177 2 systematic systematic JJ cord-333368-kjrk8nn9 177 3 review review NN cord-333368-kjrk8nn9 177 4 Cytokine cytokine NN cord-333368-kjrk8nn9 177 5 release release NN cord-333368-kjrk8nn9 177 6 syndrome syndrome NN cord-333368-kjrk8nn9 177 7 in in IN cord-333368-kjrk8nn9 177 8 severe severe JJ cord-333368-kjrk8nn9 177 9 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 177 10 Predicting predict VBG cord-333368-kjrk8nn9 177 11 severe severe JJ cord-333368-kjrk8nn9 177 12 outcomes outcome NNS cord-333368-kjrk8nn9 177 13 in in IN cord-333368-kjrk8nn9 177 14 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 177 15 A a DT cord-333368-kjrk8nn9 177 16 single single JJ cord-333368-kjrk8nn9 177 17 - - HYPH cord-333368-kjrk8nn9 177 18 cell cell NN cord-333368-kjrk8nn9 177 19 atlas atlas NN cord-333368-kjrk8nn9 177 20 of of IN cord-333368-kjrk8nn9 177 21 the the DT cord-333368-kjrk8nn9 177 22 peripheral peripheral JJ cord-333368-kjrk8nn9 177 23 immune immune JJ cord-333368-kjrk8nn9 177 24 response response NN cord-333368-kjrk8nn9 177 25 in in IN cord-333368-kjrk8nn9 177 26 patients patient NNS cord-333368-kjrk8nn9 177 27 with with IN cord-333368-kjrk8nn9 177 28 severe severe JJ cord-333368-kjrk8nn9 177 29 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 177 30 Single single JJ cord-333368-kjrk8nn9 177 31 - - HYPH cord-333368-kjrk8nn9 177 32 cell cell NN cord-333368-kjrk8nn9 177 33 landscape landscape NN cord-333368-kjrk8nn9 177 34 of of IN cord-333368-kjrk8nn9 177 35 bronchoalveolar bronchoalveolar JJ cord-333368-kjrk8nn9 177 36 immune immune JJ cord-333368-kjrk8nn9 177 37 cells cell NNS cord-333368-kjrk8nn9 177 38 in in IN cord-333368-kjrk8nn9 177 39 patients patient NNS cord-333368-kjrk8nn9 177 40 with with IN cord-333368-kjrk8nn9 177 41 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 177 42 Pathological pathological JJ cord-333368-kjrk8nn9 177 43 inflammation inflammation NN cord-333368-kjrk8nn9 177 44 in in IN cord-333368-kjrk8nn9 177 45 patients patient NNS cord-333368-kjrk8nn9 177 46 with with IN cord-333368-kjrk8nn9 177 47 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 177 48 : : : cord-333368-kjrk8nn9 177 49 a a DT cord-333368-kjrk8nn9 177 50 key key JJ cord-333368-kjrk8nn9 177 51 role role NN cord-333368-kjrk8nn9 177 52 for for IN cord-333368-kjrk8nn9 177 53 monocytes monocyte NNS cord-333368-kjrk8nn9 177 54 and and CC cord-333368-kjrk8nn9 177 55 macrophages macrophage VBZ cord-333368-kjrk8nn9 177 56 Perturbation perturbation NN cord-333368-kjrk8nn9 177 57 of of IN cord-333368-kjrk8nn9 177 58 the the DT cord-333368-kjrk8nn9 177 59 Monocyte Monocyte NNP cord-333368-kjrk8nn9 177 60 Compartment Compartment NNP cord-333368-kjrk8nn9 177 61 in in IN cord-333368-kjrk8nn9 177 62 Human Human NNP cord-333368-kjrk8nn9 177 63 Obesity Obesity NNP cord-333368-kjrk8nn9 177 64 Inflammatory inflammatory JJ cord-333368-kjrk8nn9 177 65 links link NNS cord-333368-kjrk8nn9 177 66 between between IN cord-333368-kjrk8nn9 177 67 obesity obesity NN cord-333368-kjrk8nn9 177 68 and and CC cord-333368-kjrk8nn9 177 69 metabolic metabolic JJ cord-333368-kjrk8nn9 177 70 disease disease NN cord-333368-kjrk8nn9 177 71 Immune immune JJ cord-333368-kjrk8nn9 177 72 dysfunction dysfunction NN cord-333368-kjrk8nn9 177 73 in in IN cord-333368-kjrk8nn9 177 74 patients patient NNS cord-333368-kjrk8nn9 177 75 with with IN cord-333368-kjrk8nn9 177 76 diabetes diabetes NN cord-333368-kjrk8nn9 177 77 mellitus mellitus NN cord-333368-kjrk8nn9 177 78 ( ( -LRB- cord-333368-kjrk8nn9 177 79 DM DM NNP cord-333368-kjrk8nn9 177 80 ) ) -RRB- cord-333368-kjrk8nn9 177 81 Cytokine cytokine NN cord-333368-kjrk8nn9 177 82 , , , cord-333368-kjrk8nn9 177 83 Chemokine Chemokine NNP cord-333368-kjrk8nn9 177 84 , , , cord-333368-kjrk8nn9 177 85 and and CC cord-333368-kjrk8nn9 177 86 Cytokine cytokine NN cord-333368-kjrk8nn9 177 87 Receptor Receptor NNP cord-333368-kjrk8nn9 177 88 Changes change NNS cord-333368-kjrk8nn9 178 1 Are be VBP cord-333368-kjrk8nn9 178 2 Associated associate VBN cord-333368-kjrk8nn9 178 3 With with IN cord-333368-kjrk8nn9 178 4 Metabolic metabolic JJ cord-333368-kjrk8nn9 178 5 Improvements improvement NNS cord-333368-kjrk8nn9 179 1 After after IN cord-333368-kjrk8nn9 179 2 Bariatric bariatric NN cord-333368-kjrk8nn9 179 3 Surgery surgery NN cord-333368-kjrk8nn9 179 4 CCR2 CCR2 NNP cord-333368-kjrk8nn9 179 5 modulates modulate VBZ cord-333368-kjrk8nn9 179 6 inflammatory inflammatory JJ cord-333368-kjrk8nn9 179 7 and and CC cord-333368-kjrk8nn9 179 8 metabolic metabolic JJ cord-333368-kjrk8nn9 179 9 effects effect NNS cord-333368-kjrk8nn9 179 10 of of IN cord-333368-kjrk8nn9 179 11 high high JJ cord-333368-kjrk8nn9 179 12 - - HYPH cord-333368-kjrk8nn9 179 13 fat fat NN cord-333368-kjrk8nn9 179 14 feeding feed VBG cord-333368-kjrk8nn9 179 15 Elevated elevate VBN cord-333368-kjrk8nn9 179 16 Glucose glucose NN cord-333368-kjrk8nn9 179 17 Levels level NNS cord-333368-kjrk8nn9 180 1 Favor Favor NNP cord-333368-kjrk8nn9 180 2 SARS SARS NNP cord-333368-kjrk8nn9 180 3 - - HYPH cord-333368-kjrk8nn9 180 4 CoV-2 CoV-2 NNP cord-333368-kjrk8nn9 180 5 Infection Infection NNP cord-333368-kjrk8nn9 180 6 and and CC cord-333368-kjrk8nn9 180 7 Monocyte Monocyte NNP cord-333368-kjrk8nn9 180 8 Response Response NNP cord-333368-kjrk8nn9 180 9 through through IN cord-333368-kjrk8nn9 180 10 a a DT cord-333368-kjrk8nn9 180 11 HIF-1alpha HIF-1alpha NNP cord-333368-kjrk8nn9 180 12 / / SYM cord-333368-kjrk8nn9 180 13 Glycolysis Glycolysis NNP cord-333368-kjrk8nn9 180 14 - - HYPH cord-333368-kjrk8nn9 180 15 Dependent Dependent NNP cord-333368-kjrk8nn9 180 16 Axis Axis NNP cord-333368-kjrk8nn9 180 17 Metabolically metabolically RB cord-333368-kjrk8nn9 180 18 Activated activate VBN cord-333368-kjrk8nn9 180 19 Adipose Adipose NNP cord-333368-kjrk8nn9 180 20 Tissue tissue NN cord-333368-kjrk8nn9 180 21 Macrophages macrophage NNS cord-333368-kjrk8nn9 180 22 Perform perform VBP cord-333368-kjrk8nn9 180 23 Detrimental detrimental JJ cord-333368-kjrk8nn9 180 24 and and CC cord-333368-kjrk8nn9 180 25 Beneficial Beneficial NNP cord-333368-kjrk8nn9 180 26 Functions function NNS cord-333368-kjrk8nn9 180 27 during during IN cord-333368-kjrk8nn9 180 28 Diet Diet NNP cord-333368-kjrk8nn9 180 29 - - HYPH cord-333368-kjrk8nn9 180 30 Induced induce VBN cord-333368-kjrk8nn9 180 31 Obesity obesity NN cord-333368-kjrk8nn9 180 32 Unique unique JJ cord-333368-kjrk8nn9 180 33 metabolic metabolic JJ cord-333368-kjrk8nn9 180 34 activation activation NN cord-333368-kjrk8nn9 180 35 of of IN cord-333368-kjrk8nn9 180 36 adipose adipose JJ cord-333368-kjrk8nn9 180 37 tissue tissue NN cord-333368-kjrk8nn9 180 38 macrophages macrophage NNS cord-333368-kjrk8nn9 180 39 in in IN cord-333368-kjrk8nn9 180 40 obesity obesity NN cord-333368-kjrk8nn9 180 41 promotes promote VBZ cord-333368-kjrk8nn9 180 42 inflammatory inflammatory JJ cord-333368-kjrk8nn9 180 43 responses response NNS cord-333368-kjrk8nn9 180 44 Metabolic metabolic JJ cord-333368-kjrk8nn9 180 45 dysfunction dysfunction NN cord-333368-kjrk8nn9 180 46 drives drive VBZ cord-333368-kjrk8nn9 180 47 a a DT cord-333368-kjrk8nn9 180 48 mechanistically mechanistically RB cord-333368-kjrk8nn9 180 49 distinct distinct JJ cord-333368-kjrk8nn9 180 50 proinflammatory proinflammatory JJ cord-333368-kjrk8nn9 180 51 phenotype phenotype NN cord-333368-kjrk8nn9 180 52 in in IN cord-333368-kjrk8nn9 180 53 adipose adipose JJ cord-333368-kjrk8nn9 180 54 tissue tissue NN cord-333368-kjrk8nn9 180 55 macrophages macrophage NNS cord-333368-kjrk8nn9 180 56 Adipocyte Adipocyte NNP cord-333368-kjrk8nn9 180 57 - - HYPH cord-333368-kjrk8nn9 180 58 macrophage macrophage NN cord-333368-kjrk8nn9 180 59 interaction interaction NN cord-333368-kjrk8nn9 180 60 may may MD cord-333368-kjrk8nn9 180 61 mediate mediate VB cord-333368-kjrk8nn9 180 62 LPS LPS NNP cord-333368-kjrk8nn9 180 63 - - HYPH cord-333368-kjrk8nn9 180 64 induced induce VBN cord-333368-kjrk8nn9 180 65 lowgrade lowgrade JJ cord-333368-kjrk8nn9 180 66 inflammation inflammation NN cord-333368-kjrk8nn9 180 67 : : : cord-333368-kjrk8nn9 180 68 potential potential JJ cord-333368-kjrk8nn9 180 69 link link NN cord-333368-kjrk8nn9 180 70 with with IN cord-333368-kjrk8nn9 180 71 metabolic metabolic JJ cord-333368-kjrk8nn9 180 72 complications complication NNS cord-333368-kjrk8nn9 181 1 Obesity obesity NN cord-333368-kjrk8nn9 181 2 induces induce VBZ cord-333368-kjrk8nn9 181 3 a a DT cord-333368-kjrk8nn9 181 4 phenotypic phenotypic NN cord-333368-kjrk8nn9 181 5 switch switch NN cord-333368-kjrk8nn9 181 6 in in IN cord-333368-kjrk8nn9 181 7 adipose adipose JJ cord-333368-kjrk8nn9 181 8 tissue tissue NN cord-333368-kjrk8nn9 181 9 macrophage macrophage NN cord-333368-kjrk8nn9 181 10 polarization polarization NN cord-333368-kjrk8nn9 182 1 Diet diet NN cord-333368-kjrk8nn9 182 2 - - HYPH cord-333368-kjrk8nn9 182 3 induced induce VBN cord-333368-kjrk8nn9 182 4 obesity obesity NN cord-333368-kjrk8nn9 182 5 promotes promote VBZ cord-333368-kjrk8nn9 182 6 myelopoiesis myelopoiesis NN cord-333368-kjrk8nn9 182 7 in in IN cord-333368-kjrk8nn9 182 8 hematopoietic hematopoietic JJ cord-333368-kjrk8nn9 182 9 stem stem NN cord-333368-kjrk8nn9 182 10 cells cell NNS cord-333368-kjrk8nn9 183 1 Adipose adipose JJ cord-333368-kjrk8nn9 183 2 tissue tissue NN cord-333368-kjrk8nn9 183 3 macrophages macrophage NNS cord-333368-kjrk8nn9 183 4 promote promote VBP cord-333368-kjrk8nn9 183 5 myelopoiesis myelopoiesis NN cord-333368-kjrk8nn9 183 6 and and CC cord-333368-kjrk8nn9 183 7 monocytosis monocytosis NN cord-333368-kjrk8nn9 183 8 in in IN cord-333368-kjrk8nn9 183 9 obesity obesity NN cord-333368-kjrk8nn9 183 10 Bone Bone NNP cord-333368-kjrk8nn9 183 11 marrow marrow NN cord-333368-kjrk8nn9 183 12 lympho lympho NN cord-333368-kjrk8nn9 183 13 - - HYPH cord-333368-kjrk8nn9 183 14 myeloid myeloid JJ cord-333368-kjrk8nn9 183 15 malfunction malfunction NN cord-333368-kjrk8nn9 183 16 in in IN cord-333368-kjrk8nn9 183 17 obesity obesity NN cord-333368-kjrk8nn9 183 18 requires require VBZ cord-333368-kjrk8nn9 183 19 precursor precursor NN cord-333368-kjrk8nn9 183 20 cell cell NN cord-333368-kjrk8nn9 183 21 - - HYPH cord-333368-kjrk8nn9 183 22 autonomous autonomous JJ cord-333368-kjrk8nn9 183 23 TLR4 TLR4 NNP cord-333368-kjrk8nn9 183 24 TLR4 TLR4 NNP cord-333368-kjrk8nn9 183 25 , , , cord-333368-kjrk8nn9 183 26 TRIF TRIF NNP cord-333368-kjrk8nn9 183 27 , , , cord-333368-kjrk8nn9 183 28 and and CC cord-333368-kjrk8nn9 183 29 MyD88 MyD88 NNS cord-333368-kjrk8nn9 183 30 are be VBP cord-333368-kjrk8nn9 183 31 essential essential JJ cord-333368-kjrk8nn9 183 32 for for IN cord-333368-kjrk8nn9 183 33 myelopoiesis myelopoiesis NN cord-333368-kjrk8nn9 183 34 and and CC cord-333368-kjrk8nn9 183 35 CD11c(+ CD11c(+ NNP cord-333368-kjrk8nn9 183 36 ) ) -RRB- cord-333368-kjrk8nn9 184 1 adipose adipose JJ cord-333368-kjrk8nn9 184 2 tissue tissue NN cord-333368-kjrk8nn9 184 3 macrophage macrophage NN cord-333368-kjrk8nn9 184 4 production production NN cord-333368-kjrk8nn9 184 5 in in IN cord-333368-kjrk8nn9 184 6 obese obese JJ cord-333368-kjrk8nn9 184 7 mice mouse NNS cord-333368-kjrk8nn9 185 1 Palmitate Palmitate NNP cord-333368-kjrk8nn9 185 2 Activates activate VBZ cord-333368-kjrk8nn9 185 3 CCL4 CCL4 NNP cord-333368-kjrk8nn9 185 4 Expression expression NN cord-333368-kjrk8nn9 185 5 in in IN cord-333368-kjrk8nn9 185 6 Human Human NNP cord-333368-kjrk8nn9 185 7 Monocytic Monocytic NNP cord-333368-kjrk8nn9 185 8 Cells Cells NNP cord-333368-kjrk8nn9 185 9 via via IN cord-333368-kjrk8nn9 185 10 TLR4 TLR4 NNP cord-333368-kjrk8nn9 185 11 / / SYM cord-333368-kjrk8nn9 185 12 MyD88 MyD88 NNP cord-333368-kjrk8nn9 185 13 Dependent Dependent NNP cord-333368-kjrk8nn9 185 14 Activation Activation NNP cord-333368-kjrk8nn9 185 15 of of IN cord-333368-kjrk8nn9 185 16 NF NF NNP cord-333368-kjrk8nn9 185 17 - - HYPH cord-333368-kjrk8nn9 185 18 kappaB kappaB NNP cord-333368-kjrk8nn9 186 1 /MAPK/ /MAPK/ . cord-333368-kjrk8nn9 187 1 PI3 pi3 NN cord-333368-kjrk8nn9 187 2 K K NNP cord-333368-kjrk8nn9 187 3 Signaling Signaling NNP cord-333368-kjrk8nn9 187 4 Systems Systems NNPS cord-333368-kjrk8nn9 187 5 Effect Effect NNP cord-333368-kjrk8nn9 187 6 of of IN cord-333368-kjrk8nn9 187 7 lipopolysaccharide lipopolysaccharide NN cord-333368-kjrk8nn9 187 8 on on IN cord-333368-kjrk8nn9 187 9 inflammation inflammation NN cord-333368-kjrk8nn9 187 10 and and CC cord-333368-kjrk8nn9 187 11 insulin insulin NN cord-333368-kjrk8nn9 187 12 action action NN cord-333368-kjrk8nn9 187 13 in in IN cord-333368-kjrk8nn9 187 14 human human JJ cord-333368-kjrk8nn9 187 15 muscle muscle NN cord-333368-kjrk8nn9 187 16 Endotoxins endotoxin NNS cord-333368-kjrk8nn9 187 17 are be VBP cord-333368-kjrk8nn9 187 18 associated associate VBN cord-333368-kjrk8nn9 187 19 with with IN cord-333368-kjrk8nn9 187 20 visceral visceral JJ cord-333368-kjrk8nn9 187 21 fat fat JJ cord-333368-kjrk8nn9 187 22 mass mass NN cord-333368-kjrk8nn9 187 23 in in IN cord-333368-kjrk8nn9 187 24 type type NN cord-333368-kjrk8nn9 187 25 1 1 CD cord-333368-kjrk8nn9 187 26 diabetes diabetes NN cord-333368-kjrk8nn9 188 1 TLR4/ TLR4/ NNP cord-333368-kjrk8nn9 189 1 MyD88 myd88 JJ cord-333368-kjrk8nn9 189 2 -mediated -mediated JJ cord-333368-kjrk8nn9 189 3 CCL2 CCL2 NNP cord-333368-kjrk8nn9 189 4 production production NN cord-333368-kjrk8nn9 189 5 by by IN cord-333368-kjrk8nn9 189 6 lipopolysaccharide lipopolysaccharide NN cord-333368-kjrk8nn9 189 7 ( ( -LRB- cord-333368-kjrk8nn9 189 8 endotoxin endotoxin NN cord-333368-kjrk8nn9 189 9 ) ) -RRB- cord-333368-kjrk8nn9 189 10 : : : cord-333368-kjrk8nn9 190 1 Implications implication NNS cord-333368-kjrk8nn9 190 2 for for IN cord-333368-kjrk8nn9 190 3 metabolic metabolic JJ cord-333368-kjrk8nn9 190 4 inflammation inflammation NN cord-333368-kjrk8nn9 190 5 Mechanisms mechanism NNS cord-333368-kjrk8nn9 190 6 of of IN cord-333368-kjrk8nn9 190 7 macrophage macrophage NN cord-333368-kjrk8nn9 190 8 activation activation NN cord-333368-kjrk8nn9 190 9 in in IN cord-333368-kjrk8nn9 190 10 obesityinduced obesityinduced NNP cord-333368-kjrk8nn9 190 11 insulin insulin NN cord-333368-kjrk8nn9 190 12 resistance resistance NN cord-333368-kjrk8nn9 190 13 Obesity obesity NN cord-333368-kjrk8nn9 190 14 worsens worsen VBZ cord-333368-kjrk8nn9 190 15 the the DT cord-333368-kjrk8nn9 190 16 outcome outcome NN cord-333368-kjrk8nn9 190 17 of of IN cord-333368-kjrk8nn9 190 18 influenza influenza NN cord-333368-kjrk8nn9 190 19 virus virus NN cord-333368-kjrk8nn9 190 20 infection infection NN cord-333368-kjrk8nn9 190 21 associated associate VBN cord-333368-kjrk8nn9 190 22 with with IN cord-333368-kjrk8nn9 190 23 impaired impaired JJ cord-333368-kjrk8nn9 190 24 type type NN cord-333368-kjrk8nn9 191 1 I -PRON- PRP cord-333368-kjrk8nn9 191 2 interferon interferon VBD cord-333368-kjrk8nn9 191 3 induction induction NN cord-333368-kjrk8nn9 191 4 in in IN cord-333368-kjrk8nn9 191 5 mice mouse NNS cord-333368-kjrk8nn9 192 1 Diet diet NN cord-333368-kjrk8nn9 192 2 - - HYPH cord-333368-kjrk8nn9 192 3 induced induce VBN cord-333368-kjrk8nn9 192 4 obese obese JJ cord-333368-kjrk8nn9 192 5 mice mouse NNS cord-333368-kjrk8nn9 192 6 have have VBP cord-333368-kjrk8nn9 192 7 increased increase VBN cord-333368-kjrk8nn9 192 8 mortality mortality NN cord-333368-kjrk8nn9 192 9 and and CC cord-333368-kjrk8nn9 192 10 altered alter VBN cord-333368-kjrk8nn9 192 11 immune immune JJ cord-333368-kjrk8nn9 192 12 responses response NNS cord-333368-kjrk8nn9 192 13 when when WRB cord-333368-kjrk8nn9 192 14 infected infect VBN cord-333368-kjrk8nn9 192 15 with with IN cord-333368-kjrk8nn9 192 16 influenza influenza NN cord-333368-kjrk8nn9 192 17 virus virus NN cord-333368-kjrk8nn9 192 18 Obesity obesity NN cord-333368-kjrk8nn9 192 19 Increases increase VBZ cord-333368-kjrk8nn9 192 20 Mortality Mortality NNP cord-333368-kjrk8nn9 192 21 and and CC cord-333368-kjrk8nn9 192 22 Modulates modulate VBZ cord-333368-kjrk8nn9 192 23 the the DT cord-333368-kjrk8nn9 192 24 Lung Lung NNP cord-333368-kjrk8nn9 192 25 Metabolome Metabolome NNP cord-333368-kjrk8nn9 192 26 during during IN cord-333368-kjrk8nn9 192 27 Pandemic Pandemic NNP cord-333368-kjrk8nn9 192 28 H1N1 H1N1 NNP cord-333368-kjrk8nn9 192 29 Influenza Influenza NNP cord-333368-kjrk8nn9 192 30 Virus Virus NNP cord-333368-kjrk8nn9 192 31 Infection Infection NNP cord-333368-kjrk8nn9 192 32 in in IN cord-333368-kjrk8nn9 192 33 Mice Mice NNP cord-333368-kjrk8nn9 192 34 Impact Impact NNP cord-333368-kjrk8nn9 192 35 of of IN cord-333368-kjrk8nn9 192 36 Obesity obesity NN cord-333368-kjrk8nn9 192 37 on on IN cord-333368-kjrk8nn9 192 38 Influenza Influenza NNP cord-333368-kjrk8nn9 192 39 A A NNP cord-333368-kjrk8nn9 192 40 Virus Virus NNP cord-333368-kjrk8nn9 192 41 Pathogenesis Pathogenesis NNP cord-333368-kjrk8nn9 192 42 , , , cord-333368-kjrk8nn9 192 43 Immune Immune NNP cord-333368-kjrk8nn9 192 44 Response response NN cord-333368-kjrk8nn9 192 45 , , , cord-333368-kjrk8nn9 192 46 and and CC cord-333368-kjrk8nn9 192 47 Evolution evolution NN cord-333368-kjrk8nn9 192 48 Epigenetic epigenetic JJ cord-333368-kjrk8nn9 192 49 Regulation regulation NN cord-333368-kjrk8nn9 192 50 of of IN cord-333368-kjrk8nn9 192 51 TLR4 TLR4 NNP cord-333368-kjrk8nn9 192 52 in in IN cord-333368-kjrk8nn9 192 53 Diabetic Diabetic NNP cord-333368-kjrk8nn9 192 54 Macrophages Macrophages NNP cord-333368-kjrk8nn9 192 55 Modulates modulate VBZ cord-333368-kjrk8nn9 192 56 Immunometabolism Immunometabolism NNP cord-333368-kjrk8nn9 192 57 and and CC cord-333368-kjrk8nn9 192 58 Wound Wound NNP cord-333368-kjrk8nn9 192 59 Repair Repair NNP cord-333368-kjrk8nn9 192 60 TNF TNF NNP cord-333368-kjrk8nn9 192 61 - - HYPH cord-333368-kjrk8nn9 192 62 alpha alpha NNP cord-333368-kjrk8nn9 192 63 regulates regulate VBZ cord-333368-kjrk8nn9 192 64 diabetic diabetic JJ cord-333368-kjrk8nn9 192 65 macrophage macrophage NN cord-333368-kjrk8nn9 192 66 function function NN cord-333368-kjrk8nn9 192 67 through through IN cord-333368-kjrk8nn9 192 68 the the DT cord-333368-kjrk8nn9 192 69 histone histone NN cord-333368-kjrk8nn9 192 70 acetyltransferase acetyltransferase NN cord-333368-kjrk8nn9 192 71 MOF MOF NNP cord-333368-kjrk8nn9 192 72 Ly6C(Hi ly6c(hi CD cord-333368-kjrk8nn9 192 73 ) ) -RRB- cord-333368-kjrk8nn9 193 1 Blood blood NN cord-333368-kjrk8nn9 193 2 Monocyte Monocyte NNP cord-333368-kjrk8nn9 193 3 / / SYM cord-333368-kjrk8nn9 193 4 Macrophage Macrophage NNP cord-333368-kjrk8nn9 193 5 Drive Drive NNP cord-333368-kjrk8nn9 193 6 Chronic Chronic NNP cord-333368-kjrk8nn9 193 7 Inflammation inflammation NN cord-333368-kjrk8nn9 193 8 and and CC cord-333368-kjrk8nn9 193 9 Impair impair VB cord-333368-kjrk8nn9 193 10 Wound Wound NNP cord-333368-kjrk8nn9 193 11 Healing heal VBG cord-333368-kjrk8nn9 193 12 in in IN cord-333368-kjrk8nn9 193 13 Diabetes diabetes NN cord-333368-kjrk8nn9 193 14 Mellitus Mellitus NNP cord-333368-kjrk8nn9 193 15 Upregulation Upregulation NNP cord-333368-kjrk8nn9 193 16 of of IN cord-333368-kjrk8nn9 193 17 cyclooxygenase cyclooxygenase NN cord-333368-kjrk8nn9 193 18 - - HYPH cord-333368-kjrk8nn9 193 19 II ii NN cord-333368-kjrk8nn9 193 20 gene gene NN cord-333368-kjrk8nn9 193 21 and and CC cord-333368-kjrk8nn9 193 22 PGE2 PGE2 NNP cord-333368-kjrk8nn9 193 23 production production NN cord-333368-kjrk8nn9 193 24 of of IN cord-333368-kjrk8nn9 193 25 peritoneal peritoneal JJ cord-333368-kjrk8nn9 193 26 macrophages macrophage NNS cord-333368-kjrk8nn9 193 27 in in IN cord-333368-kjrk8nn9 193 28 diabetic diabetic JJ cord-333368-kjrk8nn9 193 29 rats rat NNS cord-333368-kjrk8nn9 193 30 Epigenetic epigenetic JJ cord-333368-kjrk8nn9 193 31 Regulation regulation NN cord-333368-kjrk8nn9 193 32 of of IN cord-333368-kjrk8nn9 193 33 the the DT cord-333368-kjrk8nn9 193 34 PGE2 PGE2 NNP cord-333368-kjrk8nn9 193 35 Pathway Pathway NNP cord-333368-kjrk8nn9 193 36 Modulates modulate VBZ cord-333368-kjrk8nn9 193 37 Macrophage Macrophage NNP cord-333368-kjrk8nn9 193 38 Phenotype Phenotype NNP cord-333368-kjrk8nn9 193 39 in in IN cord-333368-kjrk8nn9 193 40 Normal normal JJ cord-333368-kjrk8nn9 193 41 and and CC cord-333368-kjrk8nn9 193 42 Pathologic Pathologic NNP cord-333368-kjrk8nn9 193 43 Wound Wound NNP cord-333368-kjrk8nn9 193 44 Repair repair NN cord-333368-kjrk8nn9 193 45 CREB CREB NNP cord-333368-kjrk8nn9 193 46 pathway pathway NN cord-333368-kjrk8nn9 193 47 links link VBZ cord-333368-kjrk8nn9 193 48 PGE2 PGE2 NNP cord-333368-kjrk8nn9 193 49 signaling signal VBG cord-333368-kjrk8nn9 193 50 with with IN cord-333368-kjrk8nn9 193 51 macrophage macrophage NN cord-333368-kjrk8nn9 193 52 polarization polarization NN cord-333368-kjrk8nn9 193 53 Prostaglandin prostaglandin NN cord-333368-kjrk8nn9 193 54 E2 E2 NNP cord-333368-kjrk8nn9 194 1 As as IN cord-333368-kjrk8nn9 194 2 a a DT cord-333368-kjrk8nn9 194 3 Modulator Modulator NNP cord-333368-kjrk8nn9 194 4 of of IN cord-333368-kjrk8nn9 194 5 Viral Viral NNP cord-333368-kjrk8nn9 194 6 Infections infection NNS cord-333368-kjrk8nn9 195 1 The the DT cord-333368-kjrk8nn9 195 2 Perfect Perfect NNP cord-333368-kjrk8nn9 195 3 Storm storm NN cord-333368-kjrk8nn9 195 4 : : : cord-333368-kjrk8nn9 195 5 Coronavirus Coronavirus NNP cord-333368-kjrk8nn9 195 6 ( ( -LRB- cord-333368-kjrk8nn9 195 7 Covid-19 Covid-19 NNP cord-333368-kjrk8nn9 195 8 ) ) -RRB- cord-333368-kjrk8nn9 195 9 Pandemic Pandemic NNP cord-333368-kjrk8nn9 195 10 Meets meet VBZ cord-333368-kjrk8nn9 195 11 Overfat Overfat NNP cord-333368-kjrk8nn9 195 12 Pandemic Pandemic NNP cord-333368-kjrk8nn9 195 13 . . . cord-333368-kjrk8nn9 196 1 Front Front NNP cord-333368-kjrk8nn9 196 2 Public Public NNP cord-333368-kjrk8nn9 196 3 Health Health NNP cord-333368-kjrk8nn9 196 4 8 8 CD cord-333368-kjrk8nn9 196 5 Risk Risk NNP cord-333368-kjrk8nn9 196 6 of of IN cord-333368-kjrk8nn9 196 7 Infection Infection NNP cord-333368-kjrk8nn9 196 8 in in IN cord-333368-kjrk8nn9 196 9 Type Type NNP cord-333368-kjrk8nn9 196 10 1 1 CD cord-333368-kjrk8nn9 196 11 and and CC cord-333368-kjrk8nn9 196 12 Type type NN cord-333368-kjrk8nn9 196 13 2 2 CD cord-333368-kjrk8nn9 196 14 Diabetes diabetes NN cord-333368-kjrk8nn9 197 1 Compared compare VBN cord-333368-kjrk8nn9 197 2 With with IN cord-333368-kjrk8nn9 197 3 the the DT cord-333368-kjrk8nn9 197 4 General General NNP cord-333368-kjrk8nn9 197 5 Population Population NNP cord-333368-kjrk8nn9 197 6 : : : cord-333368-kjrk8nn9 198 1 A a DT cord-333368-kjrk8nn9 198 2 Matched match VBN cord-333368-kjrk8nn9 198 3 Cohort Cohort NNP cord-333368-kjrk8nn9 198 4 Study Study NNP cord-333368-kjrk8nn9 198 5 Increased increase VBN cord-333368-kjrk8nn9 198 6 airway airway NN cord-333368-kjrk8nn9 198 7 glucose glucose NN cord-333368-kjrk8nn9 198 8 increases increase VBZ cord-333368-kjrk8nn9 198 9 airway airway NN cord-333368-kjrk8nn9 198 10 bacterial bacterial JJ cord-333368-kjrk8nn9 198 11 load load NN cord-333368-kjrk8nn9 198 12 in in IN cord-333368-kjrk8nn9 198 13 hyperglycaemia hyperglycaemia NNP cord-333368-kjrk8nn9 199 1 Hyperglycemia hyperglycemia NN cord-333368-kjrk8nn9 199 2 drives drive VBZ cord-333368-kjrk8nn9 199 3 intestinal intestinal JJ cord-333368-kjrk8nn9 199 4 barrier barrier NN cord-333368-kjrk8nn9 199 5 dysfunction dysfunction NN cord-333368-kjrk8nn9 199 6 and and CC cord-333368-kjrk8nn9 199 7 risk risk NN cord-333368-kjrk8nn9 199 8 for for IN cord-333368-kjrk8nn9 199 9 enteric enteric JJ cord-333368-kjrk8nn9 199 10 infection infection NN cord-333368-kjrk8nn9 199 11 Glucose glucose NN cord-333368-kjrk8nn9 199 12 depletion depletion NN cord-333368-kjrk8nn9 199 13 in in IN cord-333368-kjrk8nn9 199 14 the the DT cord-333368-kjrk8nn9 199 15 airway airway NN cord-333368-kjrk8nn9 199 16 surface surface NN cord-333368-kjrk8nn9 199 17 liquid liquid NN cord-333368-kjrk8nn9 199 18 is be VBZ cord-333368-kjrk8nn9 199 19 essential essential JJ cord-333368-kjrk8nn9 199 20 for for IN cord-333368-kjrk8nn9 199 21 sterility sterility NN cord-333368-kjrk8nn9 199 22 of of IN cord-333368-kjrk8nn9 199 23 the the DT cord-333368-kjrk8nn9 199 24 airways airway NNS cord-333368-kjrk8nn9 199 25 Bacterial bacterial JJ cord-333368-kjrk8nn9 199 26 phagocytosis phagocytosis NN cord-333368-kjrk8nn9 199 27 and and CC cord-333368-kjrk8nn9 199 28 intracellular intracellular JJ cord-333368-kjrk8nn9 199 29 killing killing NN cord-333368-kjrk8nn9 199 30 by by IN cord-333368-kjrk8nn9 199 31 alveolar alveolar JJ cord-333368-kjrk8nn9 199 32 macrophages macrophage NNS cord-333368-kjrk8nn9 199 33 in in IN cord-333368-kjrk8nn9 199 34 BB bb NN cord-333368-kjrk8nn9 199 35 rats rat NNS cord-333368-kjrk8nn9 200 1 Diabetic diabetic JJ cord-333368-kjrk8nn9 200 2 mice mouse NNS cord-333368-kjrk8nn9 200 3 display display VBP cord-333368-kjrk8nn9 200 4 a a DT cord-333368-kjrk8nn9 200 5 delayed delay VBN cord-333368-kjrk8nn9 200 6 adaptive adaptive JJ cord-333368-kjrk8nn9 200 7 immune immune JJ cord-333368-kjrk8nn9 200 8 response response NN cord-333368-kjrk8nn9 200 9 to to IN cord-333368-kjrk8nn9 200 10 Mycobacterium Mycobacterium NNP cord-333368-kjrk8nn9 200 11 tuberculosis tuberculosis NN cord-333368-kjrk8nn9 200 12 Impaired impair VBD cord-333368-kjrk8nn9 200 13 Recognition Recognition NNP cord-333368-kjrk8nn9 200 14 of of IN cord-333368-kjrk8nn9 200 15 Mycobacterium Mycobacterium NNP cord-333368-kjrk8nn9 200 16 tuberculosis tuberculosis NN cord-333368-kjrk8nn9 200 17 by by IN cord-333368-kjrk8nn9 200 18 Alveolar Alveolar NNP cord-333368-kjrk8nn9 200 19 Macrophages macrophage NNS cord-333368-kjrk8nn9 200 20 From from IN cord-333368-kjrk8nn9 200 21 Diabetic diabetic JJ cord-333368-kjrk8nn9 200 22 Mice mice NN cord-333368-kjrk8nn9 200 23 Increased increase VBD cord-333368-kjrk8nn9 200 24 susceptibility susceptibility NN cord-333368-kjrk8nn9 200 25 to to IN cord-333368-kjrk8nn9 200 26 Mycobacterium Mycobacterium NNP cord-333368-kjrk8nn9 200 27 tuberculosis tuberculosis NN cord-333368-kjrk8nn9 200 28 infection infection NN cord-333368-kjrk8nn9 200 29 in in IN cord-333368-kjrk8nn9 200 30 a a DT cord-333368-kjrk8nn9 200 31 diet diet NN cord-333368-kjrk8nn9 200 32 - - HYPH cord-333368-kjrk8nn9 200 33 induced induce VBN cord-333368-kjrk8nn9 200 34 murine murine JJ cord-333368-kjrk8nn9 200 35 model model NN cord-333368-kjrk8nn9 200 36 of of IN cord-333368-kjrk8nn9 200 37 type type NN cord-333368-kjrk8nn9 200 38 2 2 CD cord-333368-kjrk8nn9 200 39 diabetes diabetes NN cord-333368-kjrk8nn9 201 1 Leptin leptin NN cord-333368-kjrk8nn9 201 2 - - HYPH cord-333368-kjrk8nn9 201 3 deficient deficient JJ cord-333368-kjrk8nn9 201 4 mice mouse NNS cord-333368-kjrk8nn9 201 5 exhibit exhibit NN cord-333368-kjrk8nn9 201 6 impaired impair VBN cord-333368-kjrk8nn9 201 7 host host NN cord-333368-kjrk8nn9 201 8 defense defense NN cord-333368-kjrk8nn9 201 9 in in IN cord-333368-kjrk8nn9 201 10 Gramnegative Gramnegative NNP cord-333368-kjrk8nn9 201 11 pneumonia pneumonia NN cord-333368-kjrk8nn9 201 12 Mice mouse NNS cord-333368-kjrk8nn9 201 13 chronically chronically RB cord-333368-kjrk8nn9 201 14 fed feed VBD cord-333368-kjrk8nn9 201 15 high high JJ cord-333368-kjrk8nn9 201 16 - - HYPH cord-333368-kjrk8nn9 201 17 fat fat NN cord-333368-kjrk8nn9 201 18 diet diet NN cord-333368-kjrk8nn9 201 19 have have VBP cord-333368-kjrk8nn9 201 20 increased increase VBN cord-333368-kjrk8nn9 201 21 mortality mortality NN cord-333368-kjrk8nn9 201 22 and and CC cord-333368-kjrk8nn9 201 23 disturbed disturbed JJ cord-333368-kjrk8nn9 201 24 immune immune JJ cord-333368-kjrk8nn9 201 25 response response NN cord-333368-kjrk8nn9 201 26 in in IN cord-333368-kjrk8nn9 201 27 sepsis sepsis NN cord-333368-kjrk8nn9 201 28 Defects defect NNS cord-333368-kjrk8nn9 201 29 in in IN cord-333368-kjrk8nn9 201 30 early early JJ cord-333368-kjrk8nn9 201 31 cell cell NN cord-333368-kjrk8nn9 201 32 recruitment recruitment NN cord-333368-kjrk8nn9 201 33 contribute contribute VBP cord-333368-kjrk8nn9 201 34 to to IN cord-333368-kjrk8nn9 201 35 the the DT cord-333368-kjrk8nn9 201 36 increased increase VBN cord-333368-kjrk8nn9 201 37 susceptibility susceptibility NN cord-333368-kjrk8nn9 201 38 to to IN cord-333368-kjrk8nn9 201 39 respiratory respiratory JJ cord-333368-kjrk8nn9 201 40 Klebsiella Klebsiella NNP cord-333368-kjrk8nn9 201 41 pneumoniae pneumoniae NN cord-333368-kjrk8nn9 201 42 infection infection NN cord-333368-kjrk8nn9 201 43 in in IN cord-333368-kjrk8nn9 201 44 diabetic diabetic JJ cord-333368-kjrk8nn9 201 45 mice mouse NNS cord-333368-kjrk8nn9 202 1 Staphylococcus staphylococcus NN cord-333368-kjrk8nn9 202 2 aureus aureus NN cord-333368-kjrk8nn9 202 3 requires require VBZ cord-333368-kjrk8nn9 202 4 less less JJR cord-333368-kjrk8nn9 202 5 virulence virulence NN cord-333368-kjrk8nn9 202 6 to to TO cord-333368-kjrk8nn9 202 7 establish establish VB cord-333368-kjrk8nn9 202 8 an an DT cord-333368-kjrk8nn9 202 9 infection infection NN cord-333368-kjrk8nn9 202 10 in in IN cord-333368-kjrk8nn9 202 11 diabetic diabetic JJ cord-333368-kjrk8nn9 202 12 hosts host NNS cord-333368-kjrk8nn9 202 13 Obesity obesity NN cord-333368-kjrk8nn9 202 14 Exacerbates exacerbate VBZ cord-333368-kjrk8nn9 203 1 Sepsis sepsis NN cord-333368-kjrk8nn9 203 2 - - HYPH cord-333368-kjrk8nn9 203 3 Induced induce VBN cord-333368-kjrk8nn9 203 4 Oxidative oxidative JJ cord-333368-kjrk8nn9 203 5 Damage damage NN cord-333368-kjrk8nn9 203 6 in in IN cord-333368-kjrk8nn9 203 7 Organs organ NNS cord-333368-kjrk8nn9 204 1 GM GM NNP cord-333368-kjrk8nn9 204 2 - - HYPH cord-333368-kjrk8nn9 204 3 CSF CSF NNP cord-333368-kjrk8nn9 204 4 Administration Administration NNP cord-333368-kjrk8nn9 204 5 Improves improve VBZ cord-333368-kjrk8nn9 204 6 Defects defect NNS cord-333368-kjrk8nn9 204 7 in in IN cord-333368-kjrk8nn9 204 8 Innate Innate NNP cord-333368-kjrk8nn9 204 9 Immunity Immunity NNP cord-333368-kjrk8nn9 204 10 and and CC cord-333368-kjrk8nn9 204 11 Sepsis Sepsis NNP cord-333368-kjrk8nn9 204 12 Survival Survival NNP cord-333368-kjrk8nn9 204 13 in in IN cord-333368-kjrk8nn9 204 14 Obese obese JJ cord-333368-kjrk8nn9 204 15 Diabetic diabetic JJ cord-333368-kjrk8nn9 204 16 Mice Mice NNP cord-333368-kjrk8nn9 204 17 Short short JJ cord-333368-kjrk8nn9 204 18 - - HYPH cord-333368-kjrk8nn9 204 19 term term NN cord-333368-kjrk8nn9 204 20 consumption consumption NN cord-333368-kjrk8nn9 204 21 of of IN cord-333368-kjrk8nn9 204 22 a a DT cord-333368-kjrk8nn9 204 23 high high JJ cord-333368-kjrk8nn9 204 24 - - HYPH cord-333368-kjrk8nn9 204 25 fat fat NN cord-333368-kjrk8nn9 204 26 diet diet NN cord-333368-kjrk8nn9 204 27 increases increase NNS cord-333368-kjrk8nn9 204 28 host host NN cord-333368-kjrk8nn9 204 29 susceptibility susceptibility NN cord-333368-kjrk8nn9 204 30 to to IN cord-333368-kjrk8nn9 204 31 Listeria Listeria NNP cord-333368-kjrk8nn9 204 32 monocytogenes monocytogene NNS cord-333368-kjrk8nn9 204 33 infection infection NN cord-333368-kjrk8nn9 204 34 Metabolic Metabolic NNP cord-333368-kjrk8nn9 204 35 Syndrome Syndrome NNP cord-333368-kjrk8nn9 204 36 and and CC cord-333368-kjrk8nn9 204 37 Risk Risk NNP cord-333368-kjrk8nn9 204 38 of of IN cord-333368-kjrk8nn9 204 39 Cervical Cervical NNP cord-333368-kjrk8nn9 204 40 Human Human NNP cord-333368-kjrk8nn9 204 41 Papillomavirus Papillomavirus NNP cord-333368-kjrk8nn9 204 42 Incident Incident NNP cord-333368-kjrk8nn9 204 43 and and CC cord-333368-kjrk8nn9 204 44 Persistent Persistent NNP cord-333368-kjrk8nn9 204 45 Infection Infection NNP cord-333368-kjrk8nn9 204 46 Morbid morbid JJ cord-333368-kjrk8nn9 204 47 obesity obesity NN cord-333368-kjrk8nn9 204 48 as as IN cord-333368-kjrk8nn9 204 49 a a DT cord-333368-kjrk8nn9 204 50 risk risk NN cord-333368-kjrk8nn9 204 51 factor factor NN cord-333368-kjrk8nn9 204 52 for for IN cord-333368-kjrk8nn9 204 53 hospitalization hospitalization NN cord-333368-kjrk8nn9 204 54 and and CC cord-333368-kjrk8nn9 204 55 death death NN cord-333368-kjrk8nn9 204 56 due due IN cord-333368-kjrk8nn9 204 57 to to IN cord-333368-kjrk8nn9 204 58 2009 2009 CD cord-333368-kjrk8nn9 204 59 pandemic pandemic NN cord-333368-kjrk8nn9 204 60 influenza influenza NN cord-333368-kjrk8nn9 204 61 A(H1N1 A(H1N1 NNP cord-333368-kjrk8nn9 204 62 ) ) -RRB- cord-333368-kjrk8nn9 205 1 disease disease NNP cord-333368-kjrk8nn9 206 1 Obese obese JJ cord-333368-kjrk8nn9 206 2 mice mouse NNS cord-333368-kjrk8nn9 206 3 have have VBP cord-333368-kjrk8nn9 206 4 increased increase VBN cord-333368-kjrk8nn9 206 5 morbidity morbidity NN cord-333368-kjrk8nn9 206 6 and and CC cord-333368-kjrk8nn9 206 7 mortality mortality NN cord-333368-kjrk8nn9 206 8 compared compare VBN cord-333368-kjrk8nn9 206 9 to to IN cord-333368-kjrk8nn9 206 10 non non JJ cord-333368-kjrk8nn9 206 11 - - JJ cord-333368-kjrk8nn9 206 12 obese obese JJ cord-333368-kjrk8nn9 206 13 mice mouse NNS cord-333368-kjrk8nn9 206 14 during during IN cord-333368-kjrk8nn9 206 15 infection infection NN cord-333368-kjrk8nn9 206 16 with with IN cord-333368-kjrk8nn9 206 17 the the DT cord-333368-kjrk8nn9 206 18 2009 2009 CD cord-333368-kjrk8nn9 206 19 pandemic pandemic NN cord-333368-kjrk8nn9 206 20 H1N1 H1N1 NNP cord-333368-kjrk8nn9 206 21 influenza influenza NN cord-333368-kjrk8nn9 206 22 virus virus NN cord-333368-kjrk8nn9 207 1 The the DT cord-333368-kjrk8nn9 207 2 impact impact NN cord-333368-kjrk8nn9 207 3 of of IN cord-333368-kjrk8nn9 207 4 obesity obesity NN cord-333368-kjrk8nn9 207 5 and and CC cord-333368-kjrk8nn9 207 6 timely timely RB cord-333368-kjrk8nn9 207 7 antiviral antiviral JJ cord-333368-kjrk8nn9 207 8 administration administration NN cord-333368-kjrk8nn9 207 9 on on IN cord-333368-kjrk8nn9 207 10 severe severe JJ cord-333368-kjrk8nn9 207 11 influenza influenza NN cord-333368-kjrk8nn9 207 12 outcomes outcome NNS cord-333368-kjrk8nn9 207 13 among among IN cord-333368-kjrk8nn9 207 14 hospitalized hospitalize VBN cord-333368-kjrk8nn9 207 15 adults adult NNS cord-333368-kjrk8nn9 207 16 Association Association NNP cord-333368-kjrk8nn9 207 17 of of IN cord-333368-kjrk8nn9 207 18 Initial Initial NNP cord-333368-kjrk8nn9 207 19 Viral Viral NNP cord-333368-kjrk8nn9 207 20 Load Load NNP cord-333368-kjrk8nn9 207 21 in in IN cord-333368-kjrk8nn9 207 22 Severe severe JJ cord-333368-kjrk8nn9 207 23 Acute acute JJ cord-333368-kjrk8nn9 207 24 Respiratory Respiratory NNP cord-333368-kjrk8nn9 207 25 Syndrome Syndrome NNP cord-333368-kjrk8nn9 207 26 Coronavirus Coronavirus NNP cord-333368-kjrk8nn9 207 27 2 2 CD cord-333368-kjrk8nn9 208 1 ( ( -LRB- cord-333368-kjrk8nn9 208 2 SARS SARS NNP cord-333368-kjrk8nn9 208 3 - - HYPH cord-333368-kjrk8nn9 208 4 CoV-2 CoV-2 NNP cord-333368-kjrk8nn9 208 5 ) ) -RRB- cord-333368-kjrk8nn9 208 6 Patients patient NNS cord-333368-kjrk8nn9 208 7 with with IN cord-333368-kjrk8nn9 208 8 Outcome outcome NN cord-333368-kjrk8nn9 208 9 and and CC cord-333368-kjrk8nn9 208 10 Symptoms symptom NNS cord-333368-kjrk8nn9 208 11 Obesity obesity NN cord-333368-kjrk8nn9 208 12 Impairs impair VBZ cord-333368-kjrk8nn9 208 13 the the DT cord-333368-kjrk8nn9 208 14 Adaptive Adaptive NNP cord-333368-kjrk8nn9 208 15 Immune Immune NNP cord-333368-kjrk8nn9 208 16 Response Response NNP cord-333368-kjrk8nn9 208 17 to to IN cord-333368-kjrk8nn9 208 18 Influenza Influenza NNP cord-333368-kjrk8nn9 208 19 Virus Virus NNP cord-333368-kjrk8nn9 208 20 Coronaviridae Coronaviridae NNP cord-333368-kjrk8nn9 208 21 Study Study NNP cord-333368-kjrk8nn9 208 22 Group Group NNP cord-333368-kjrk8nn9 208 23 of of IN cord-333368-kjrk8nn9 208 24 the the DT cord-333368-kjrk8nn9 208 25 International International NNP cord-333368-kjrk8nn9 208 26 Committee Committee NNP cord-333368-kjrk8nn9 208 27 on on IN cord-333368-kjrk8nn9 208 28 Taxonomy Taxonomy NNP cord-333368-kjrk8nn9 208 29 of of IN cord-333368-kjrk8nn9 208 30 , , , cord-333368-kjrk8nn9 208 31 V. V. NNP cord-333368-kjrk8nn9 209 1 The the DT cord-333368-kjrk8nn9 209 2 species specie NNS cord-333368-kjrk8nn9 209 3 Severe severe JJ cord-333368-kjrk8nn9 209 4 acute acute JJ cord-333368-kjrk8nn9 209 5 respiratory respiratory JJ cord-333368-kjrk8nn9 209 6 syndrome syndrome NN cord-333368-kjrk8nn9 209 7 - - HYPH cord-333368-kjrk8nn9 209 8 related relate VBN cord-333368-kjrk8nn9 209 9 coronavirus coronavirus NN cord-333368-kjrk8nn9 209 10 : : : cord-333368-kjrk8nn9 209 11 classifying classify VBG cord-333368-kjrk8nn9 209 12 2019-nCoV 2019-ncov CD cord-333368-kjrk8nn9 209 13 and and CC cord-333368-kjrk8nn9 209 14 naming name VBG cord-333368-kjrk8nn9 209 15 it -PRON- PRP cord-333368-kjrk8nn9 209 16 SARS SARS NNP cord-333368-kjrk8nn9 209 17 - - HYPH cord-333368-kjrk8nn9 209 18 CoV-2 CoV-2 NNP cord-333368-kjrk8nn9 209 19 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 209 20 and and CC cord-333368-kjrk8nn9 209 21 comorbidities comorbiditie NNS cord-333368-kjrk8nn9 209 22 : : : cord-333368-kjrk8nn9 209 23 A a DT cord-333368-kjrk8nn9 209 24 role role NN cord-333368-kjrk8nn9 209 25 for for IN cord-333368-kjrk8nn9 209 26 dipeptidyl dipeptidyl JJ cord-333368-kjrk8nn9 209 27 peptidase peptidase NN cord-333368-kjrk8nn9 209 28 4 4 CD cord-333368-kjrk8nn9 209 29 ( ( -LRB- cord-333368-kjrk8nn9 209 30 DPP4 DPP4 NNP cord-333368-kjrk8nn9 209 31 ) ) -RRB- cord-333368-kjrk8nn9 209 32 in in IN cord-333368-kjrk8nn9 209 33 disease disease NN cord-333368-kjrk8nn9 209 34 severity severity NN cord-333368-kjrk8nn9 209 35 ? ? . cord-333368-kjrk8nn9 210 1 Expression expression NN cord-333368-kjrk8nn9 210 2 of of IN cord-333368-kjrk8nn9 210 3 the the DT cord-333368-kjrk8nn9 210 4 SARS SARS NNP cord-333368-kjrk8nn9 210 5 - - HYPH cord-333368-kjrk8nn9 210 6 CoV-2 CoV-2 NNP cord-333368-kjrk8nn9 210 7 cell cell NN cord-333368-kjrk8nn9 210 8 receptor receptor NN cord-333368-kjrk8nn9 210 9 gene gene NN cord-333368-kjrk8nn9 210 10 ACE2 ACE2 NNP cord-333368-kjrk8nn9 210 11 in in IN cord-333368-kjrk8nn9 210 12 a a DT cord-333368-kjrk8nn9 210 13 wide wide JJ cord-333368-kjrk8nn9 210 14 variety variety NN cord-333368-kjrk8nn9 210 15 of of IN cord-333368-kjrk8nn9 210 16 human human JJ cord-333368-kjrk8nn9 210 17 tissues tissue NNS cord-333368-kjrk8nn9 210 18 Detection Detection NNP cord-333368-kjrk8nn9 210 19 of of IN cord-333368-kjrk8nn9 210 20 SARS SARS NNP cord-333368-kjrk8nn9 210 21 - - HYPH cord-333368-kjrk8nn9 210 22 CoV-2 CoV-2 NNP cord-333368-kjrk8nn9 210 23 in in IN cord-333368-kjrk8nn9 210 24 Different different JJ cord-333368-kjrk8nn9 210 25 Types type NNS cord-333368-kjrk8nn9 210 26 of of IN cord-333368-kjrk8nn9 210 27 Clinical clinical JJ cord-333368-kjrk8nn9 210 28 Specimens specimen NNS cord-333368-kjrk8nn9 211 1 The the DT cord-333368-kjrk8nn9 211 2 Role role NN cord-333368-kjrk8nn9 211 3 of of IN cord-333368-kjrk8nn9 211 4 Adipocytes Adipocytes NNPS cord-333368-kjrk8nn9 211 5 and and CC cord-333368-kjrk8nn9 211 6 Adipocyte Adipocyte NNP cord-333368-kjrk8nn9 211 7 - - HYPH cord-333368-kjrk8nn9 211 8 Like Like NNP cord-333368-kjrk8nn9 211 9 Cells cell NNS cord-333368-kjrk8nn9 211 10 in in IN cord-333368-kjrk8nn9 211 11 the the DT cord-333368-kjrk8nn9 211 12 Severity severity NN cord-333368-kjrk8nn9 211 13 of of IN cord-333368-kjrk8nn9 211 14 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 211 15 Infections Infections NNPS cord-333368-kjrk8nn9 211 16 Histopathology Histopathology NNP cord-333368-kjrk8nn9 211 17 and and CC cord-333368-kjrk8nn9 211 18 genetic genetic JJ cord-333368-kjrk8nn9 211 19 susceptibility susceptibility NN cord-333368-kjrk8nn9 211 20 in in IN cord-333368-kjrk8nn9 211 21 COVID-19 covid-19 JJ cord-333368-kjrk8nn9 211 22 pneumonia pneumonia NN cord-333368-kjrk8nn9 211 23 Is be VBZ cord-333368-kjrk8nn9 211 24 Adipose Adipose NNP cord-333368-kjrk8nn9 211 25 Tissue tissue NN cord-333368-kjrk8nn9 212 1 a a DT cord-333368-kjrk8nn9 212 2 Reservoir Reservoir NNP cord-333368-kjrk8nn9 212 3 for for IN cord-333368-kjrk8nn9 212 4 Viral Viral NNP cord-333368-kjrk8nn9 212 5 Spread Spread NNP cord-333368-kjrk8nn9 212 6 , , , cord-333368-kjrk8nn9 212 7 Immune Immune NNP cord-333368-kjrk8nn9 212 8 Activation Activation NNP cord-333368-kjrk8nn9 212 9 , , , cord-333368-kjrk8nn9 212 10 and and CC cord-333368-kjrk8nn9 212 11 Cytokine cytokine NN cord-333368-kjrk8nn9 212 12 Amplification Amplification NNP cord-333368-kjrk8nn9 212 13 in in IN cord-333368-kjrk8nn9 212 14 Coronavirus Coronavirus NNP cord-333368-kjrk8nn9 212 15 Disease Disease NNP cord-333368-kjrk8nn9 213 1 The the DT cord-333368-kjrk8nn9 213 2 initiation initiation NN cord-333368-kjrk8nn9 213 3 of of IN cord-333368-kjrk8nn9 213 4 metabolic metabolic JJ cord-333368-kjrk8nn9 213 5 inflammation inflammation NN cord-333368-kjrk8nn9 213 6 in in IN cord-333368-kjrk8nn9 213 7 childhood childhood NN cord-333368-kjrk8nn9 213 8 obesity obesity NN cord-333368-kjrk8nn9 213 9 Role role NN cord-333368-kjrk8nn9 213 10 of of IN cord-333368-kjrk8nn9 213 11 the the DT cord-333368-kjrk8nn9 213 12 Gut Gut NNP cord-333368-kjrk8nn9 213 13 Microbiome Microbiome NNP cord-333368-kjrk8nn9 213 14 in in IN cord-333368-kjrk8nn9 213 15 the the DT cord-333368-kjrk8nn9 213 16 Pathogenesis Pathogenesis NNP cord-333368-kjrk8nn9 213 17 of of IN cord-333368-kjrk8nn9 213 18 Obesity Obesity NNP cord-333368-kjrk8nn9 213 19 and and CC cord-333368-kjrk8nn9 213 20 Obesity Obesity NNP cord-333368-kjrk8nn9 213 21 - - HYPH cord-333368-kjrk8nn9 213 22 Related relate VBN cord-333368-kjrk8nn9 213 23 Metabolic metabolic JJ cord-333368-kjrk8nn9 213 24 Dysfunction dysfunction NN cord-333368-kjrk8nn9 214 1 The the DT cord-333368-kjrk8nn9 214 2 Intestinal Intestinal NNP cord-333368-kjrk8nn9 214 3 Immune Immune NNP cord-333368-kjrk8nn9 214 4 System System NNP cord-333368-kjrk8nn9 214 5 in in IN cord-333368-kjrk8nn9 214 6 Obesity Obesity NNP cord-333368-kjrk8nn9 214 7 and and CC cord-333368-kjrk8nn9 214 8 Insulin Insulin NNP cord-333368-kjrk8nn9 214 9 Resistance Resistance NNP cord-333368-kjrk8nn9 214 10 Depicting depict VBG cord-333368-kjrk8nn9 214 11 SARS SARS NNP cord-333368-kjrk8nn9 214 12 - - HYPH cord-333368-kjrk8nn9 214 13 CoV-2 CoV-2 NNP cord-333368-kjrk8nn9 214 14 faecal faecal JJ cord-333368-kjrk8nn9 214 15 viral viral JJ cord-333368-kjrk8nn9 214 16 activity activity NN cord-333368-kjrk8nn9 214 17 in in IN cord-333368-kjrk8nn9 214 18 association association NN cord-333368-kjrk8nn9 214 19 with with IN cord-333368-kjrk8nn9 214 20 gut gut NN cord-333368-kjrk8nn9 214 21 microbiota microbiota NN cord-333368-kjrk8nn9 214 22 composition composition NN cord-333368-kjrk8nn9 214 23 in in IN cord-333368-kjrk8nn9 214 24 patients patient NNS cord-333368-kjrk8nn9 214 25 with with IN cord-333368-kjrk8nn9 214 26 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 214 27 Gut Gut NNP cord-333368-kjrk8nn9 214 28 Microbes Microbes NNPS cord-333368-kjrk8nn9 214 29 and and CC cord-333368-kjrk8nn9 214 30 Health Health NNP cord-333368-kjrk8nn9 214 31 : : : cord-333368-kjrk8nn9 215 1 A a DT cord-333368-kjrk8nn9 215 2 Focus Focus NNP cord-333368-kjrk8nn9 215 3 on on IN cord-333368-kjrk8nn9 215 4 the the DT cord-333368-kjrk8nn9 215 5 Mechanisms mechanism NNS cord-333368-kjrk8nn9 216 1 Linking link VBG cord-333368-kjrk8nn9 216 2 Microbes microbe NNS cord-333368-kjrk8nn9 216 3 , , , cord-333368-kjrk8nn9 216 4 Obesity obesity NN cord-333368-kjrk8nn9 216 5 , , , cord-333368-kjrk8nn9 216 6 and and CC cord-333368-kjrk8nn9 216 7 Related Related NNP cord-333368-kjrk8nn9 216 8 Disorders Disorders NNPS cord-333368-kjrk8nn9 216 9 Differences Differences NNPS cord-333368-kjrk8nn9 216 10 in in IN cord-333368-kjrk8nn9 216 11 airway airway NN cord-333368-kjrk8nn9 216 12 microbiome microbiome NN cord-333368-kjrk8nn9 216 13 and and CC cord-333368-kjrk8nn9 216 14 metabolome metabolome NN cord-333368-kjrk8nn9 216 15 of of IN cord-333368-kjrk8nn9 216 16 single single JJ cord-333368-kjrk8nn9 216 17 lung lung NN cord-333368-kjrk8nn9 216 18 transplant transplant NN cord-333368-kjrk8nn9 216 19 recipients recipient NNS cord-333368-kjrk8nn9 216 20 Genomewide Genomewide NNP cord-333368-kjrk8nn9 216 21 Association Association NNP cord-333368-kjrk8nn9 216 22 Study Study NNP cord-333368-kjrk8nn9 216 23 of of IN cord-333368-kjrk8nn9 216 24 Severe Severe NNP cord-333368-kjrk8nn9 216 25 Covid-19 covid-19 NN cord-333368-kjrk8nn9 216 26 with with IN cord-333368-kjrk8nn9 216 27 Respiratory respiratory JJ cord-333368-kjrk8nn9 216 28 Failure failure NN cord-333368-kjrk8nn9 217 1 The the DT cord-333368-kjrk8nn9 217 2 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 217 3 Host Host NNP cord-333368-kjrk8nn9 217 4 Genetics Genetics NNP cord-333368-kjrk8nn9 217 5 Initiative Initiative NNP cord-333368-kjrk8nn9 217 6 , , , cord-333368-kjrk8nn9 217 7 a a DT cord-333368-kjrk8nn9 217 8 global global JJ cord-333368-kjrk8nn9 217 9 initiative initiative NN cord-333368-kjrk8nn9 217 10 to to TO cord-333368-kjrk8nn9 217 11 elucidate elucidate VB cord-333368-kjrk8nn9 217 12 the the DT cord-333368-kjrk8nn9 217 13 role role NN cord-333368-kjrk8nn9 217 14 of of IN cord-333368-kjrk8nn9 217 15 host host JJ cord-333368-kjrk8nn9 217 16 genetic genetic JJ cord-333368-kjrk8nn9 217 17 factors factor NNS cord-333368-kjrk8nn9 217 18 in in IN cord-333368-kjrk8nn9 217 19 susceptibility susceptibility NN cord-333368-kjrk8nn9 217 20 and and CC cord-333368-kjrk8nn9 217 21 severity severity NN cord-333368-kjrk8nn9 217 22 of of IN cord-333368-kjrk8nn9 217 23 the the DT cord-333368-kjrk8nn9 217 24 SARS SARS NNP cord-333368-kjrk8nn9 217 25 - - HYPH cord-333368-kjrk8nn9 217 26 CoV-2 CoV-2 NNP cord-333368-kjrk8nn9 217 27 virus virus NN cord-333368-kjrk8nn9 217 28 pandemic pandemic NN cord-333368-kjrk8nn9 217 29 Genome Genome NNP cord-333368-kjrk8nn9 217 30 - - HYPH cord-333368-kjrk8nn9 217 31 wide wide JJ cord-333368-kjrk8nn9 217 32 association association NN cord-333368-kjrk8nn9 217 33 analyses analysis NNS cord-333368-kjrk8nn9 217 34 identify identify VBP cord-333368-kjrk8nn9 217 35 143 143 CD cord-333368-kjrk8nn9 217 36 risk risk NN cord-333368-kjrk8nn9 217 37 variants variant NNS cord-333368-kjrk8nn9 217 38 and and CC cord-333368-kjrk8nn9 217 39 putative putative JJ cord-333368-kjrk8nn9 217 40 regulatory regulatory JJ cord-333368-kjrk8nn9 217 41 mechanisms mechanism NNS cord-333368-kjrk8nn9 217 42 for for IN cord-333368-kjrk8nn9 217 43 type type NN cord-333368-kjrk8nn9 217 44 2 2 CD cord-333368-kjrk8nn9 217 45 diabetes diabetes NN cord-333368-kjrk8nn9 218 1 The the DT cord-333368-kjrk8nn9 218 2 trinity trinity NN cord-333368-kjrk8nn9 218 3 of of IN cord-333368-kjrk8nn9 218 4 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 218 5 : : : cord-333368-kjrk8nn9 218 6 immunity immunity NN cord-333368-kjrk8nn9 218 7 , , , cord-333368-kjrk8nn9 218 8 inflammation inflammation NN cord-333368-kjrk8nn9 218 9 and and CC cord-333368-kjrk8nn9 218 10 intervention intervention NN cord-333368-kjrk8nn9 218 11 Metabolically metabolically RB cord-333368-kjrk8nn9 218 12 healthy healthy JJ cord-333368-kjrk8nn9 218 13 obesity obesity NN cord-333368-kjrk8nn9 218 14 : : : cord-333368-kjrk8nn9 218 15 facts fact NNS cord-333368-kjrk8nn9 218 16 and and CC cord-333368-kjrk8nn9 218 17 fantasies fantasy NNS cord-333368-kjrk8nn9 218 18 Contribution Contribution NNP cord-333368-kjrk8nn9 218 19 of of IN cord-333368-kjrk8nn9 218 20 adipogenesis adipogenesis NN cord-333368-kjrk8nn9 218 21 to to IN cord-333368-kjrk8nn9 218 22 healthy healthy JJ cord-333368-kjrk8nn9 218 23 adipose adipose JJ cord-333368-kjrk8nn9 218 24 tissue tissue NN cord-333368-kjrk8nn9 218 25 expansion expansion NN cord-333368-kjrk8nn9 218 26 in in IN cord-333368-kjrk8nn9 218 27 obesity obesity NN cord-333368-kjrk8nn9 218 28 Sex sex NN cord-333368-kjrk8nn9 218 29 differences difference NNS cord-333368-kjrk8nn9 218 30 in in IN cord-333368-kjrk8nn9 218 31 the the DT cord-333368-kjrk8nn9 218 32 response response NN cord-333368-kjrk8nn9 218 33 to to IN cord-333368-kjrk8nn9 218 34 viral viral JJ cord-333368-kjrk8nn9 218 35 infections infection NNS cord-333368-kjrk8nn9 218 36 : : : cord-333368-kjrk8nn9 219 1 TLR8 TLR8 NNP cord-333368-kjrk8nn9 219 2 and and CC cord-333368-kjrk8nn9 219 3 TLR9 tlr9 JJ cord-333368-kjrk8nn9 219 4 ligand ligand NN cord-333368-kjrk8nn9 219 5 stimulation stimulation NN cord-333368-kjrk8nn9 219 6 induce induce VBP cord-333368-kjrk8nn9 219 7 higher high JJR cord-333368-kjrk8nn9 219 8 IL10 IL10 NNP cord-333368-kjrk8nn9 219 9 production production NN cord-333368-kjrk8nn9 219 10 in in IN cord-333368-kjrk8nn9 219 11 males male NNS cord-333368-kjrk8nn9 220 1 Gender gender NN cord-333368-kjrk8nn9 220 2 differences difference NNS cord-333368-kjrk8nn9 220 3 in in IN cord-333368-kjrk8nn9 220 4 cytokine cytokine JJ cord-333368-kjrk8nn9 220 5 secretion secretion NN cord-333368-kjrk8nn9 220 6 by by IN cord-333368-kjrk8nn9 220 7 human human JJ cord-333368-kjrk8nn9 220 8 peripheral peripheral JJ cord-333368-kjrk8nn9 220 9 blood blood NN cord-333368-kjrk8nn9 220 10 mononuclear mononuclear NN cord-333368-kjrk8nn9 220 11 cells cell NNS cord-333368-kjrk8nn9 220 12 : : : cord-333368-kjrk8nn9 220 13 role role NN cord-333368-kjrk8nn9 220 14 of of IN cord-333368-kjrk8nn9 220 15 estrogen estrogen NN cord-333368-kjrk8nn9 220 16 in in IN cord-333368-kjrk8nn9 220 17 modulating modulate VBG cord-333368-kjrk8nn9 220 18 LPS LPS NNP cord-333368-kjrk8nn9 220 19 - - HYPH cord-333368-kjrk8nn9 220 20 induced induce VBN cord-333368-kjrk8nn9 220 21 cytokine cytokine JJ cord-333368-kjrk8nn9 220 22 secretion secretion NN cord-333368-kjrk8nn9 220 23 in in IN cord-333368-kjrk8nn9 220 24 an an DT cord-333368-kjrk8nn9 220 25 ex ex FW cord-333368-kjrk8nn9 220 26 vivo vivo NN cord-333368-kjrk8nn9 220 27 septic septic JJ cord-333368-kjrk8nn9 220 28 model model NN cord-333368-kjrk8nn9 220 29 Sexual sexual JJ cord-333368-kjrk8nn9 220 30 dimorphism dimorphism NN cord-333368-kjrk8nn9 220 31 in in IN cord-333368-kjrk8nn9 220 32 expression expression NN cord-333368-kjrk8nn9 220 33 of of IN cord-333368-kjrk8nn9 220 34 receptors receptor NNS cord-333368-kjrk8nn9 220 35 for for IN cord-333368-kjrk8nn9 220 36 bacterial bacterial JJ cord-333368-kjrk8nn9 220 37 lipopolysaccharides lipopolysaccharide NNS cord-333368-kjrk8nn9 220 38 in in IN cord-333368-kjrk8nn9 220 39 murine murine JJ cord-333368-kjrk8nn9 220 40 macrophages macrophage NNS cord-333368-kjrk8nn9 220 41 : : : cord-333368-kjrk8nn9 220 42 a a DT cord-333368-kjrk8nn9 220 43 possible possible JJ cord-333368-kjrk8nn9 220 44 mechanism mechanism NN cord-333368-kjrk8nn9 220 45 for for IN cord-333368-kjrk8nn9 220 46 gender gender NN cord-333368-kjrk8nn9 220 47 - - HYPH cord-333368-kjrk8nn9 220 48 based base VBN cord-333368-kjrk8nn9 220 49 differences difference NNS cord-333368-kjrk8nn9 220 50 in in IN cord-333368-kjrk8nn9 220 51 endotoxic endotoxic JJ cord-333368-kjrk8nn9 220 52 shock shock NN cord-333368-kjrk8nn9 220 53 susceptibility susceptibility NN cord-333368-kjrk8nn9 220 54 Worse bad JJR cord-333368-kjrk8nn9 220 55 progression progression NN cord-333368-kjrk8nn9 220 56 of of IN cord-333368-kjrk8nn9 220 57 COVID-19 covid-19 CD cord-333368-kjrk8nn9 220 58 in in IN cord-333368-kjrk8nn9 220 59 men man NNS cord-333368-kjrk8nn9 220 60 : : : cord-333368-kjrk8nn9 221 1 Is be VBZ cord-333368-kjrk8nn9 221 2 testosterone testosterone NN cord-333368-kjrk8nn9 221 3 a a DT cord-333368-kjrk8nn9 221 4 key key JJ cord-333368-kjrk8nn9 221 5 factor factor NN cord-333368-kjrk8nn9 221 6 ? ? . cord-333368-kjrk8nn9 222 1 Differences difference NNS cord-333368-kjrk8nn9 222 2 in in IN cord-333368-kjrk8nn9 222 3 Hematopoietic Hematopoietic NNP cord-333368-kjrk8nn9 222 4 Stem Stem NNP cord-333368-kjrk8nn9 222 5 Cells cell NNS cord-333368-kjrk8nn9 222 6 Contribute contribute VBP cord-333368-kjrk8nn9 222 7 to to IN cord-333368-kjrk8nn9 222 8 Sexually sexually RB cord-333368-kjrk8nn9 222 9 Dimorphic dimorphic JJ cord-333368-kjrk8nn9 222 10 Inflammatory inflammatory JJ cord-333368-kjrk8nn9 222 11 Responses response NNS cord-333368-kjrk8nn9 222 12 to to IN cord-333368-kjrk8nn9 222 13 High high JJ cord-333368-kjrk8nn9 222 14 Fat fat JJ cord-333368-kjrk8nn9 222 15 Diet diet NN cord-333368-kjrk8nn9 222 16 - - HYPH cord-333368-kjrk8nn9 222 17 induced induce VBN cord-333368-kjrk8nn9 222 18 Obesity obesity NN cord-333368-kjrk8nn9 222 19 Sex Sex NNP cord-333368-kjrk8nn9 222 20 Differences difference NNS cord-333368-kjrk8nn9 222 21 in in IN cord-333368-kjrk8nn9 222 22 Inflammatory Inflammatory NNP cord-333368-kjrk8nn9 222 23 Responses response NNS cord-333368-kjrk8nn9 222 24 to to IN cord-333368-kjrk8nn9 222 25 Adipose Adipose NNP cord-333368-kjrk8nn9 222 26 Tissue Tissue NNP cord-333368-kjrk8nn9 222 27 Lipolysis Lipolysis NNP cord-333368-kjrk8nn9 222 28 in in IN cord-333368-kjrk8nn9 222 29 Diet Diet NNP cord-333368-kjrk8nn9 222 30 - - HYPH cord-333368-kjrk8nn9 222 31 Induced induce VBN cord-333368-kjrk8nn9 222 32 Obesity obesity NN cord-333368-kjrk8nn9 222 33 Sex sex NN cord-333368-kjrk8nn9 222 34 Differences difference NNS cord-333368-kjrk8nn9 222 35 in in IN cord-333368-kjrk8nn9 222 36 the the DT cord-333368-kjrk8nn9 222 37 Effect effect NN cord-333368-kjrk8nn9 222 38 of of IN cord-333368-kjrk8nn9 222 39 Inflammation inflammation NN cord-333368-kjrk8nn9 222 40 on on IN cord-333368-kjrk8nn9 222 41 Subjective subjective JJ cord-333368-kjrk8nn9 222 42 Social Social NNP cord-333368-kjrk8nn9 222 43 Status status NN cord-333368-kjrk8nn9 222 44 : : : cord-333368-kjrk8nn9 222 45 A a DT cord-333368-kjrk8nn9 222 46 Randomized Randomized NNP cord-333368-kjrk8nn9 222 47 Controlled Controlled NNP cord-333368-kjrk8nn9 222 48 Trial Trial NNP cord-333368-kjrk8nn9 222 49 of of IN cord-333368-kjrk8nn9 222 50 Endotoxin Endotoxin NNP cord-333368-kjrk8nn9 222 51 in in IN cord-333368-kjrk8nn9 222 52 Healthy Healthy NNP cord-333368-kjrk8nn9 222 53 Young Young NNP cord-333368-kjrk8nn9 222 54 Adults Adults NNPS cord-333368-kjrk8nn9 223 1 Sex sex NN cord-333368-kjrk8nn9 223 2 differences difference NNS cord-333368-kjrk8nn9 223 3 in in IN cord-333368-kjrk8nn9 223 4 obesity obesity NN cord-333368-kjrk8nn9 223 5 , , , cord-333368-kjrk8nn9 223 6 lipid lipid NN cord-333368-kjrk8nn9 223 7 metabolism metabolism NN cord-333368-kjrk8nn9 223 8 , , , cord-333368-kjrk8nn9 223 9 and and CC cord-333368-kjrk8nn9 223 10 inflammation inflammation NN cord-333368-kjrk8nn9 223 11 - - : cord-333368-kjrk8nn9 223 12 A a DT cord-333368-kjrk8nn9 223 13 role role NN cord-333368-kjrk8nn9 223 14 for for IN cord-333368-kjrk8nn9 223 15 the the DT cord-333368-kjrk8nn9 223 16 sex sex NN cord-333368-kjrk8nn9 223 17 chromosomes chromosome NNS cord-333368-kjrk8nn9 223 18 ? ? . cord-333368-kjrk8nn9 224 1 Endocrine endocrine JJ cord-333368-kjrk8nn9 224 2 and and CC cord-333368-kjrk8nn9 224 3 metabolic metabolic JJ cord-333368-kjrk8nn9 224 4 link link NN cord-333368-kjrk8nn9 224 5 to to IN cord-333368-kjrk8nn9 224 6 coronavirus coronavirus NN cord-333368-kjrk8nn9 224 7 infection infection NN cord-333368-kjrk8nn9 224 8 Obesity obesity NN cord-333368-kjrk8nn9 224 9 and and CC cord-333368-kjrk8nn9 224 10 SARS SARS NNP cord-333368-kjrk8nn9 224 11 - - HYPH cord-333368-kjrk8nn9 224 12 CoV-2 CoV-2 NNP cord-333368-kjrk8nn9 224 13 : : : cord-333368-kjrk8nn9 225 1 A a DT cord-333368-kjrk8nn9 225 2 population population NN cord-333368-kjrk8nn9 225 3 to to TO cord-333368-kjrk8nn9 225 4 safeguard safeguard VB cord-333368-kjrk8nn9 225 5 The the DT cord-333368-kjrk8nn9 225 6 X X NNS cord-333368-kjrk8nn9 225 7 - - NNS cord-333368-kjrk8nn9 225 8 files file NNS cord-333368-kjrk8nn9 225 9 in in IN cord-333368-kjrk8nn9 225 10 immunity immunity NN cord-333368-kjrk8nn9 226 1 : : : cord-333368-kjrk8nn9 226 2 sex sex NN cord-333368-kjrk8nn9 226 3 - - HYPH cord-333368-kjrk8nn9 226 4 based base VBN cord-333368-kjrk8nn9 226 5 differences difference NNS cord-333368-kjrk8nn9 226 6 predispose predispose VBP cord-333368-kjrk8nn9 226 7 immune immune JJ cord-333368-kjrk8nn9 226 8 responses response NNS cord-333368-kjrk8nn9 226 9 Female female JJ cord-333368-kjrk8nn9 226 10 mice mouse NNS cord-333368-kjrk8nn9 226 11 are be VBP cord-333368-kjrk8nn9 226 12 protected protect VBN cord-333368-kjrk8nn9 226 13 against against IN cord-333368-kjrk8nn9 226 14 high high JJ cord-333368-kjrk8nn9 226 15 - - HYPH cord-333368-kjrk8nn9 226 16 fat fat NN cord-333368-kjrk8nn9 226 17 diet diet NN cord-333368-kjrk8nn9 226 18 induced induce VBN cord-333368-kjrk8nn9 226 19 metabolic metabolic JJ cord-333368-kjrk8nn9 226 20 syndrome syndrome NN cord-333368-kjrk8nn9 226 21 and and CC cord-333368-kjrk8nn9 226 22 increase increase VB cord-333368-kjrk8nn9 226 23 the the DT cord-333368-kjrk8nn9 226 24 regulatory regulatory JJ cord-333368-kjrk8nn9 226 25 T t NN cord-333368-kjrk8nn9 226 26 cell cell NN cord-333368-kjrk8nn9 226 27 population population NN cord-333368-kjrk8nn9 226 28 in in IN cord-333368-kjrk8nn9 226 29 adipose adipose JJ cord-333368-kjrk8nn9 226 30 tissue tissue NN cord-333368-kjrk8nn9 226 31 Prevention Prevention NNP cord-333368-kjrk8nn9 226 32 of of IN cord-333368-kjrk8nn9 226 33 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 226 34 in in IN cord-333368-kjrk8nn9 226 35 Older old JJR cord-333368-kjrk8nn9 226 36 Adults Adults NNPS cord-333368-kjrk8nn9 226 37 : : : cord-333368-kjrk8nn9 227 1 A a DT cord-333368-kjrk8nn9 227 2 Brief brief JJ cord-333368-kjrk8nn9 227 3 Guidance Guidance NNP cord-333368-kjrk8nn9 227 4 from from IN cord-333368-kjrk8nn9 227 5 the the DT cord-333368-kjrk8nn9 227 6 International International NNP cord-333368-kjrk8nn9 227 7 Association Association NNP cord-333368-kjrk8nn9 227 8 for for IN cord-333368-kjrk8nn9 227 9 Gerontology Gerontology NNP cord-333368-kjrk8nn9 227 10 and and CC cord-333368-kjrk8nn9 227 11 Geriatrics Geriatrics NNP cord-333368-kjrk8nn9 227 12 ( ( -LRB- cord-333368-kjrk8nn9 227 13 IAGG IAGG NNP cord-333368-kjrk8nn9 227 14 ) ) -RRB- cord-333368-kjrk8nn9 228 1 Asia Asia NNP cord-333368-kjrk8nn9 228 2 / / SYM cord-333368-kjrk8nn9 228 3 Oceania Oceania NNP cord-333368-kjrk8nn9 228 4 region region NN cord-333368-kjrk8nn9 228 5 Association Association NNP cord-333368-kjrk8nn9 228 6 between between IN cord-333368-kjrk8nn9 228 7 age age NN cord-333368-kjrk8nn9 228 8 and and CC cord-333368-kjrk8nn9 228 9 clinical clinical JJ cord-333368-kjrk8nn9 228 10 characteristics characteristic NNS cord-333368-kjrk8nn9 228 11 and and CC cord-333368-kjrk8nn9 228 12 outcomes outcome NNS cord-333368-kjrk8nn9 228 13 of of IN cord-333368-kjrk8nn9 228 14 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 228 15 Is be VBZ cord-333368-kjrk8nn9 228 16 BMI BMI NNP cord-333368-kjrk8nn9 228 17 higher high JJR cord-333368-kjrk8nn9 228 18 in in IN cord-333368-kjrk8nn9 228 19 younger young JJR cord-333368-kjrk8nn9 228 20 patients patient NNS cord-333368-kjrk8nn9 228 21 with with IN cord-333368-kjrk8nn9 229 1 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 229 2 ? ? . cord-333368-kjrk8nn9 229 3 Association Association NNP cord-333368-kjrk8nn9 229 4 between between IN cord-333368-kjrk8nn9 229 5 BMI BMI NNP cord-333368-kjrk8nn9 229 6 and and CC cord-333368-kjrk8nn9 229 7 COVID-19 covid-19 JJ cord-333368-kjrk8nn9 229 8 hospitalization hospitalization NN cord-333368-kjrk8nn9 229 9 by by IN cord-333368-kjrk8nn9 229 10 age age NN cord-333368-kjrk8nn9 229 11 Meta Meta NNP cord-333368-kjrk8nn9 229 12 - - HYPH cord-333368-kjrk8nn9 229 13 inflammaging inflammage VBG cord-333368-kjrk8nn9 229 14 at at IN cord-333368-kjrk8nn9 229 15 the the DT cord-333368-kjrk8nn9 229 16 crossroad crossroad NN cord-333368-kjrk8nn9 229 17 of of IN cord-333368-kjrk8nn9 229 18 geroscience geroscience NNP cord-333368-kjrk8nn9 229 19 Pathophysiology Pathophysiology NNP cord-333368-kjrk8nn9 229 20 of of IN cord-333368-kjrk8nn9 229 21 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 230 1 : : : cord-333368-kjrk8nn9 230 2 Why why WRB cord-333368-kjrk8nn9 230 3 Children child NNS cord-333368-kjrk8nn9 230 4 Fare fare VBP cord-333368-kjrk8nn9 230 5 Better well RBR cord-333368-kjrk8nn9 230 6 than than IN cord-333368-kjrk8nn9 230 7 Adults Adults NNPS cord-333368-kjrk8nn9 230 8 ? ? . cord-333368-kjrk8nn9 231 1 SARS SARS NNP cord-333368-kjrk8nn9 231 2 - - HYPH cord-333368-kjrk8nn9 231 3 CoV-2 CoV-2 NNP cord-333368-kjrk8nn9 231 4 infection infection NN cord-333368-kjrk8nn9 231 5 in in IN cord-333368-kjrk8nn9 231 6 children child NNS cord-333368-kjrk8nn9 231 7 : : : cord-333368-kjrk8nn9 231 8 Transmission transmission NN cord-333368-kjrk8nn9 231 9 dynamics dynamic NNS cord-333368-kjrk8nn9 231 10 and and CC cord-333368-kjrk8nn9 231 11 clinical clinical JJ cord-333368-kjrk8nn9 231 12 characteristics characteristic NNS cord-333368-kjrk8nn9 231 13 Clinical clinical JJ cord-333368-kjrk8nn9 231 14 characteristics characteristic NNS cord-333368-kjrk8nn9 231 15 and and CC cord-333368-kjrk8nn9 231 16 diagnostic diagnostic JJ cord-333368-kjrk8nn9 231 17 challenges challenge NNS cord-333368-kjrk8nn9 231 18 of of IN cord-333368-kjrk8nn9 231 19 pediatric pediatric JJ cord-333368-kjrk8nn9 231 20 COVID-19 covid-19 CD cord-333368-kjrk8nn9 231 21 : : : cord-333368-kjrk8nn9 231 22 A a DT cord-333368-kjrk8nn9 231 23 systematic systematic JJ cord-333368-kjrk8nn9 231 24 review review NN cord-333368-kjrk8nn9 231 25 and and CC cord-333368-kjrk8nn9 231 26 meta meta NNP cord-333368-kjrk8nn9 231 27 - - HYPH cord-333368-kjrk8nn9 231 28 analysis analysis NN cord-333368-kjrk8nn9 231 29 Clinical Clinical NNP cord-333368-kjrk8nn9 231 30 Features Features NNPS cord-333368-kjrk8nn9 231 31 , , , cord-333368-kjrk8nn9 231 32 and and CC cord-333368-kjrk8nn9 231 33 Disease Disease NNP cord-333368-kjrk8nn9 231 34 Severity Severity NNP cord-333368-kjrk8nn9 231 35 in in IN cord-333368-kjrk8nn9 231 36 Patients patient NNS cord-333368-kjrk8nn9 231 37 With with IN cord-333368-kjrk8nn9 231 38 Coronavirus Coronavirus NNP cord-333368-kjrk8nn9 231 39 Disease Disease NNP cord-333368-kjrk8nn9 231 40 2019 2019 CD cord-333368-kjrk8nn9 231 41 ( ( -LRB- cord-333368-kjrk8nn9 231 42 COVID-19 COVID-19 NNP cord-333368-kjrk8nn9 231 43 ) ) -RRB- cord-333368-kjrk8nn9 231 44 in in IN cord-333368-kjrk8nn9 231 45 a a DT cord-333368-kjrk8nn9 231 46 Children Children NNP cord-333368-kjrk8nn9 231 47 's 's POS cord-333368-kjrk8nn9 231 48 Hospital Hospital NNP cord-333368-kjrk8nn9 231 49 in in IN cord-333368-kjrk8nn9 231 50 Glycemic Glycemic NNP cord-333368-kjrk8nn9 231 51 Characteristics Characteristics NNPS cord-333368-kjrk8nn9 231 52 and and CC cord-333368-kjrk8nn9 231 53 Clinical Clinical NNP cord-333368-kjrk8nn9 231 54 Outcomes Outcomes NNPS cord-333368-kjrk8nn9 231 55 of of IN cord-333368-kjrk8nn9 231 56 COVID-19 covid-19 JJ cord-333368-kjrk8nn9 231 57 Patients patient NNS cord-333368-kjrk8nn9 231 58 Hospitalized hospitalize VBN cord-333368-kjrk8nn9 231 59 in in IN cord-333368-kjrk8nn9 231 60 the the DT cord-333368-kjrk8nn9 231 61 United United NNP cord-333368-kjrk8nn9 231 62 States States NNP cord-333368-kjrk8nn9 231 63 ACE2 ACE2 NNP cord-333368-kjrk8nn9 231 64 Expression expression NN cord-333368-kjrk8nn9 231 65 in in IN cord-333368-kjrk8nn9 231 66 Pancreas pancreas NN cord-333368-kjrk8nn9 232 1 May May MD cord-333368-kjrk8nn9 232 2 Cause cause VB cord-333368-kjrk8nn9 232 3 Pancreatic pancreatic JJ cord-333368-kjrk8nn9 232 4 Damage damage NN cord-333368-kjrk8nn9 233 1 After after IN cord-333368-kjrk8nn9 233 2 SARS SARS NNP cord-333368-kjrk8nn9 233 3 - - HYPH cord-333368-kjrk8nn9 233 4 CoV-2 CoV-2 NNP cord-333368-kjrk8nn9 233 5 Infection infection NN cord-333368-kjrk8nn9 233 6 Diabetic diabetic JJ cord-333368-kjrk8nn9 233 7 ketoacidosis ketoacidosis NN cord-333368-kjrk8nn9 233 8 precipitated precipitate VBN cord-333368-kjrk8nn9 233 9 by by IN cord-333368-kjrk8nn9 233 10 Covid-19 Covid-19 NNP cord-333368-kjrk8nn9 233 11 in in IN cord-333368-kjrk8nn9 233 12 a a DT cord-333368-kjrk8nn9 233 13 patient patient NN cord-333368-kjrk8nn9 233 14 with with IN cord-333368-kjrk8nn9 233 15 newly newly RB cord-333368-kjrk8nn9 233 16 diagnosed diagnose VBN cord-333368-kjrk8nn9 233 17 diabetes diabetes NN cord-333368-kjrk8nn9 233 18 mellitus mellitus NN cord-333368-kjrk8nn9 233 19 Binding Binding NNP cord-333368-kjrk8nn9 233 20 of of IN cord-333368-kjrk8nn9 233 21 SARS SARS NNP cord-333368-kjrk8nn9 233 22 coronavirus coronavirus NN cord-333368-kjrk8nn9 233 23 to to IN cord-333368-kjrk8nn9 233 24 its -PRON- PRP$ cord-333368-kjrk8nn9 233 25 receptor receptor NN cord-333368-kjrk8nn9 233 26 damages damage NNS cord-333368-kjrk8nn9 233 27 islets islet NNS cord-333368-kjrk8nn9 233 28 and and CC cord-333368-kjrk8nn9 233 29 causes cause VBZ cord-333368-kjrk8nn9 233 30 acute acute JJ cord-333368-kjrk8nn9 233 31 diabetes diabete VBZ cord-333368-kjrk8nn9 233 32 New New NNP cord-333368-kjrk8nn9 233 33 - - HYPH cord-333368-kjrk8nn9 233 34 Onset Onset NNP cord-333368-kjrk8nn9 233 35 Diabetes diabete NNS cord-333368-kjrk8nn9 233 36 in in IN cord-333368-kjrk8nn9 233 37 Covid-19 Covid-19 NNP cord-333368-kjrk8nn9 233 38 Remdesivir Remdesivir NNP cord-333368-kjrk8nn9 233 39 for for IN cord-333368-kjrk8nn9 233 40 the the DT cord-333368-kjrk8nn9 233 41 Treatment Treatment NNP cord-333368-kjrk8nn9 233 42 of of IN cord-333368-kjrk8nn9 233 43 Covid-19 Covid-19 NNP cord-333368-kjrk8nn9 233 44 -Preliminary -Preliminary NNP cord-333368-kjrk8nn9 233 45 Report Report NNP cord-333368-kjrk8nn9 233 46 Remdesivir Remdesivir NNP cord-333368-kjrk8nn9 233 47 in in IN cord-333368-kjrk8nn9 233 48 adults adult NNS cord-333368-kjrk8nn9 233 49 with with IN cord-333368-kjrk8nn9 233 50 severe severe JJ cord-333368-kjrk8nn9 233 51 COVID-19 covid-19 NN cord-333368-kjrk8nn9 233 52 : : : cord-333368-kjrk8nn9 233 53 a a DT cord-333368-kjrk8nn9 233 54 randomised randomised JJ cord-333368-kjrk8nn9 233 55 , , , cord-333368-kjrk8nn9 233 56 doubleblind doubleblind NN cord-333368-kjrk8nn9 233 57 , , , cord-333368-kjrk8nn9 233 58 placebo placebo NN cord-333368-kjrk8nn9 233 59 - - HYPH cord-333368-kjrk8nn9 233 60 controlled control VBN cord-333368-kjrk8nn9 234 1 , , , cord-333368-kjrk8nn9 234 2 multicentre multicentre NNP cord-333368-kjrk8nn9 234 3 trial trial NN cord-333368-kjrk8nn9 234 4 A A NNP cord-333368-kjrk8nn9 234 5 c c NN cord-333368-kjrk8nn9 234 6 c c NN cord-333368-kjrk8nn9 234 7 e e NN cord-333368-kjrk8nn9 234 8 p p NN cord-333368-kjrk8nn9 235 1 t t NNP cord-333368-kjrk8nn9 235 2 e e NNP cord-333368-kjrk8nn9 235 3 d d NNP cord-333368-kjrk8nn9 235 4 M M NNP cord-333368-kjrk8nn9 235 5 a a NNP cord-333368-kjrk8nn9 236 1 n n CC cord-333368-kjrk8nn9 236 2 u u NNP cord-333368-kjrk8nn9 236 3 s s NNP cord-333368-kjrk8nn9 236 4 c c NN cord-333368-kjrk8nn9 236 5 r r NN cord-333368-kjrk8nn9 237 1 i i PRP cord-333368-kjrk8nn9 238 1 p p NN cord-333368-kjrk8nn9 238 2 t t NN cord-333368-kjrk8nn9 239 1 22 22 CD cord-333368-kjrk8nn9 239 2 A a NN cord-333368-kjrk8nn9 240 1 c c NNP cord-333368-kjrk8nn9 240 2 c c NN cord-333368-kjrk8nn9 240 3 e e NN cord-333368-kjrk8nn9 240 4 p p NN cord-333368-kjrk8nn9 241 1 t t NNP cord-333368-kjrk8nn9 241 2 e e NNP cord-333368-kjrk8nn9 241 3 d d NNP cord-333368-kjrk8nn9 241 4 M M NNP cord-333368-kjrk8nn9 241 5 a a NNP cord-333368-kjrk8nn9 242 1 n n CC cord-333368-kjrk8nn9 242 2 u u NNP cord-333368-kjrk8nn9 242 3 s s NNP cord-333368-kjrk8nn9 242 4 c c NN cord-333368-kjrk8nn9 242 5 r r NN cord-333368-kjrk8nn9 242 6 i i PRP cord-333368-kjrk8nn9 243 1 p p NN cord-333368-kjrk8nn9 243 2 t t NN cord-333368-kjrk8nn9 243 3 A a NN cord-333368-kjrk8nn9 244 1 c c NNP cord-333368-kjrk8nn9 244 2 c c NN cord-333368-kjrk8nn9 244 3 e e NN cord-333368-kjrk8nn9 244 4 p p NN cord-333368-kjrk8nn9 245 1 t t NNP cord-333368-kjrk8nn9 245 2 e e NNP cord-333368-kjrk8nn9 245 3 d d NNP cord-333368-kjrk8nn9 245 4 M M NNP cord-333368-kjrk8nn9 245 5 a a NNP cord-333368-kjrk8nn9 246 1 n n CC cord-333368-kjrk8nn9 246 2 u u NNP cord-333368-kjrk8nn9 246 3 s s NNP cord-333368-kjrk8nn9 246 4 c c NN cord-333368-kjrk8nn9 246 5 r r NN cord-333368-kjrk8nn9 247 1 i i PRP cord-333368-kjrk8nn9 248 1 p p NN cord-333368-kjrk8nn9 248 2 t t NN cord-333368-kjrk8nn9 248 3 25 25 CD cord-333368-kjrk8nn9 248 4 _SP