id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-286029-rafcdzhm	Bogaards, Johannes Antonie	The potential of targeted antibody prophylaxis in SARS outbreak control: A mathematic analysis()	2006-05-05		.txt	text/plain	5574	291	46	METHOD: We developed a mathematical model to investigate the effects of hospital admission and targeted antibody prophylaxis on the reproduction number R, defined as the number of secondary cases generated by an index case, during different SARS outbreak scenarios. RESULTS: Assuming a basic reproduction number R(0)=3, admission of patients to hospital within 4.3 days of symptom onset is necessary to achieve outbreak control without the need to further reduce community-based transmission. Based on our model, we derived an expression for the effective reproduction number of SARS to study conditions for containment and we explored how the size and duration of an outbreak depend on the efficacy of control. Given functions for the distribution of onset-to-admission time and transmission rate before the implementation of public health measures, we define the basic reproduction number R 0 as the average number of secondary cases before intervention is in place.	./cache/cord-286029-rafcdzhm.txt	./txt/cord-286029-rafcdzhm.txt