id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-010910-hz2vyw6c	Huang, Xinyue	Macrophage-like THP-1 cells show effective uptake of silica nanoparticles carrying inactivated diphtheria toxoid for vaccination	2020-01-08		.txt	text/plain	6889	403	58	title: Macrophage-like THP-1 cells show effective uptake of silica nanoparticles carrying inactivated diphtheria toxoid for vaccination Porous silica has been identified as an effective adjuvant for more than a decade, and we have therefore investigated the take up rate by an immortalized macrophage-like cell line of a number of mesoporous silica nanoparticles (MSNPs) with differing diameter and pore size. Our previous work compared the antigen loading and unloading capacity of mesoporous silica nanoparticles (MSNPs), with a variety of different pore sizes, and external diameters (Huang et al. To assess the uptake of the different silica nanoparticles, and to determine whether this was affected by size, porosity or loading, we tested the ability of the particles to be taken up into macrophage-like cells. We investigated a range of sizes of silica nanoparticles to determine the effect on uptake by THP-1 macrophage-like cells.	./cache/cord-010910-hz2vyw6c.txt	./txt/cord-010910-hz2vyw6c.txt