id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-002294-qa8e90qv	Hayakawa, Sho	Efficacy of recombinant human soluble thrombomodulin for the treatment of acute exacerbation of idiopathic pulmonary fibrosis: a single arm, non-randomized prospective clinical trial	2016-11-07		.txt	text/plain	4522	232	47	title: Efficacy of recombinant human soluble thrombomodulin for the treatment of acute exacerbation of idiopathic pulmonary fibrosis: a single arm, non-randomized prospective clinical trial The administration of recombinant human soluble thrombomodulin (rhTM), which has both anti-inflammatory and anticoagulant activities, improves outcomes and respiratory function in patients with acute respiratory distress syndrome. Study data were compared with historical untreated comparison group, including 13 patients with AE-IPF who were treated without rhTM before the registration. Recombinant human soluble thrombomodulin (rhTM) demonstrates anticoagulation effects superior to heparin for the treatment of disseminated intravascular coagulation (DIC) [12] and improves the outcomes and respiratory functions in patients with sepsis-induced acute respiratory distress syndrome (ARDS) [13] . The patients who met any of the following conditions were excluded: 1) those with previous history of AE-IPF; 2) who was receiving corticosteroids or immunosuppressants; 3) who was receiving anti-coagulant therapy; 4) who had intracranial hemorrhage, pulmonary hemorrhage and/or gastrointestinal hemorrhage; 5) those with previous history of hypersensitivity against thrombomodulin; 6) those with active infectious disease; and 7) who was or possibly pregnant at the time of registration.	./cache/cord-002294-qa8e90qv.txt	./txt/cord-002294-qa8e90qv.txt