id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-006508-rje9bnph	Ballas, Samir K.	Sickle Cell Anaemia: Progress in Pathogenesis and Treatment	2012-10-10		.txt	text/plain	14697	848	49	Lack of understanding of the nature and pathophysiology of the pain associated with sickle cell anaemia hampered rational approaches of therapy and had an adverse effect on the quality of life of an already compromised health status of affected patients. Beneficial effects of hydroxyurea in patients with sickle cell anaemia Decreases the frequency of acute painful episodes Decreases the incidence of acute chest syndrome Decreases the blood transfusion requirement Decreases morbidity and mortality error where a change of one letter of a keyword of a manuscript ('punctuation mutation') corrupts the meaning of the intended message. [48] These include: (i) the risk associated with the inhibiting effect of MAb 73E on platelet function with an unpredictable net clinical effect (i.e. thrombosis versus bleeding); and (ii) to be effective, these antibodies have to be administered before the RBC adhere to the vessel wall (i.e., pre-treatment before the onset of a vaso-occlusive event) a scenario that is unpredictable in patients with sickle cell anaemia.	./cache/cord-006508-rje9bnph.txt	./txt/cord-006508-rje9bnph.txt