id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-009982-zgbu46fo	Cies, Jeffrey J.	Peramivir for Influenza A and B Viral Infections: A Pharmacokinetic Case Series	2019-10-04		.txt	text/plain	2899	167	40	DESIGN: Retrospective electronic medical record review of prospectively collected data from critically ill children receiving peramivir for influenza A or B viral infections in the pediatric intensive care unit (PICU). CONCLUSION: The pharmacokinetics of PRV demonstrated in this PICU cohort differs in comparison to healthy pediatric and adult patients, and alterations to dosing regimens may be needed in PICU patients to achieve pharmacodynamic exposures. 20 The current FDA-approved pediatric dosing regimen is recommended based on pharmacokinetic data to approximate a total drug exposure or AUC similar to that achieved in adults that was associated with safety and efficacy. 3 The pharmacokinetic data from these 11 PICU patients suggest that dosing modifications would be needed for PRV to better achieve drug exposures similar to those described earlier 3 and in the PI.	./cache/cord-009982-zgbu46fo.txt	./txt/cord-009982-zgbu46fo.txt