id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-011297-4um9w2dx	Brunker, Lucille	New-Onset Refractory Status Epilepticus with Underlying Autoimmune Etiology: a Case Report	2019-11-28		.txt	text/plain	2954	147	38	Despite treatment with multiple anti-epileptic drugs in addition to IV anesthetics, burst suppression was initially unsustainable and the patient remained in super-refractory status epilepticus. Clinical response with a goal of 1–2 bursts per screen on EEG monitor was eventually achieved after a course of rituximab and plasma exchange therapy as well as a 7-day barbiturate coma with a regimen of clobazam, lacosamide, Keppra, and oxcarbazepine followed by a slow taper of phenobarbital and the addition of fosphenytoin. We discuss treatment strategies for new-onset refractory status epilepticus and highlight the role of rapid initiation of burst suppression with high-dose IV anesthetics to ensure neuroprotection while the underlying etiology is addressed with immune-modulating therapy. A midazolam infusion was initiated and up-titrated to 60 mg h −1 but failed to achieve burst suppression, and the patient continued to have generalized epileptic discharges on EEG.	./cache/cord-011297-4um9w2dx.txt	./txt/cord-011297-4um9w2dx.txt