id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-016110-mlwe7fzz	Specks, Ulrich	Pulmonary Manifestations of Vasculitis	2014-05-05		.txt	text/plain	7833	415	36	In the context of a vasculitis syndrome, the lungs and lower airways can be affected by three major pathologic processes: (1) infl ammatory cell infi ltration and necrosis of the pulmonary parenchyma; (2) infl ammation of the tracheobronchial tree often leading to stenoses; and (3) pulmonary capillaritis causing diffuse alveolar hemorrhage (DAH). DAH can result from a variety of underlying or associated conditions that cause a disruption of the alveolarcapillary basement membrane integrity including immunological infl ammatory conditions causing immune-complex deposition or capillaritis (e.g., anti-GBM disease (Goodpasture's), systemic lupus erythematosus (SLE), ANCA-associated vasculitis), direct chemical/toxic injury (e.g., from toxic or chemical inhalation, abciximab use, all-trans-retinoic acid, trimellitic anhydride, or smoked crack cocaine), physical trauma (e.g., pulmonary contusion), and increased vascular pressure within the capillaries (e.g., mitral stenosis or severe left ventricular failure) (Table 10 .1 ).	./cache/cord-016110-mlwe7fzz.txt	./txt/cord-016110-mlwe7fzz.txt