id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-019043-cqmqwl3i	Fidalgo, Pedro	Chronic Kidney Disease in the Intensive Care Unit	2014-03-08		.txt	text/plain	8675	409	32	The incidence and prevalence of chronic kidney disease (CKD) and end-stage renal disease are increasing, and these patients have a higher risk of developing critical illness and being admitted to the intensive care unit (ICU) compared to the general population. Factors that have been shown to be associated with ICU mortality in ESRD patients are older age, higher illness severity score (i.e., APACHE II or SAPS II), burden of nonrenal organ dysfunction/failure, medical or nonsurgical admission type, and provision and duration of life-sustaining technologies (i.e., mechanical ventilation, vasopressor therapy). Synthetic colloids, such as hydroxyethyl starch (HES), have appeal for resuscitation fluids based on the premise that they attenuate the inflammatory response, mitigate endothelial barrier dysfunction, improve microcirculatory flow, and contribute to more rapid hemodynamic stabilization; however, accumulated data have now suggested use of these fluids in critical illness is associated with dosedependent risk for severe AKI requiring RRT, bleeding complications, and death (Box 32.2).	./cache/cord-019043-cqmqwl3i.txt	./txt/cord-019043-cqmqwl3i.txt