id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-277535-u283k70i	Vaja, Rakesh	Drugs and the liver	2020-09-22		.txt	text/plain	4012	239	49	Additionally, drugs can also modify how the liver functions and cause dysfunction or even failure of the organ both by a direct effect on the liver or by alteration in liver blood flow. Furthermore, once a patient has been recognized to be suffering with liver dysfunction or failure drug choice and dosing regime will need to be rationalized. After reading this article you should: C understand the mechanisms of drug metabolism by the liver C have an appreciation of alterations to drug choice and dosing regimens in patients with liver disease due to their altered pharmacokinetics C know the management of a patient with paracetamol overdose There are many different isoforms of CYP450, classified according to their amino acid sequencing into families, subfamilies and individual genes. NSAIDS are contraindicated for systemic use in most liver disease patients, because of increased bioavalibilty, the high risk of precipitating gastrointestinal bleeding and renal failure.	./cache/cord-277535-u283k70i.txt	./txt/cord-277535-u283k70i.txt