id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-279052-8hxdfdls	Boet, S.	Protocol for a multicentre randomized controlled trial of normobaric versus hyperbaric oxygen therapy for hypoxemic COVID-19 patients	2020-07-16		.txt	text/plain	4123	247	46	Secondary outcomes will include: (a) clinical outcomes (length of hospital stay, days with oxygen supplementation, oxygen flow values to obtain a saturation by pulse oximetry [≥]90%, intensive care admission and length of stay, days on invasive mechanical ventilation or high flow oxygen, sleep quality, fatigue, major thrombotic events, the 7-level COVID ordinal outcomes scale on Day 28; mortality, safety); (b) biological outcomes (plasma inflammatory markers); and (c) health system outcomes (cost of care and cost-effectiveness). Secondary objectives: To evaluate the effect of HBOT on: (a) other clinical outcomes (i.e., length of hospital stay; days with oxygen supplementation; daily oxygen flow values required to obtain saturation values ≥90%; ICU admission; ICU length of stay; days on invasive mechanical ventilation or high flow oxygenation; major arterial and venous thrombotic events, such as stroke, pulmonary embolism, deep vein thrombosis; sleep quality; fatigue; the 7-level COVID ordinal outcomes scale assessed on Day 28, mortality, and safety; (b) biologic inflammatory markers, including markers of immune activation response and inflammation; and (c) cost of care for COVID-19 patients and cost-effectiveness of HBOT.	./cache/cord-279052-8hxdfdls.txt	./txt/cord-279052-8hxdfdls.txt