id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-289930-7xm6q68s	Li, Yang	Corticosteroid prevents COVID-19 progression within its therapeutic window: a multicentre, proof-of-concept, observational study	2020-08-21		.txt	text/plain	4331	199	42	In this study, we test the hypothesis that short-term, low-to-moderate-dose corticosteroids would benefit patients when used in the early phase of excessive inflammation, namely, the therapeutic window. According to the currently known molecular mechanisms and pathophysiology data on severe acute respiratory syndrome (SARS), middle east respiratory syndrome (MERS), and influenza patients, critically ill patients usually undergo the following stages: virus invasion, immune activation, excessive inflammatory response, acute respiratory distress syndrome (ARDS), and, in the end, possible recovery or death [6] [7] [8] [9] [10] [11] . Among COVID-19 patients with marked radiologic progression, short-term, low-to-moderate-dose corticosteroids could benefit patients with LDH levels of less than two times ULN, who may be in the early phase of excessive inflammation. Among COVID-19 patients with marked radiologic progression, short-term, low-to-moderate-dose corticosteroids could benefit patients with LDH levels of less than two times ULN, who may be in the early phase of excessive inflammation.	./cache/cord-289930-7xm6q68s.txt	./txt/cord-289930-7xm6q68s.txt