id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-306062-g9hk1iq5	Silverman, Dustin A.	Respiratory and pulmonary complications in head and neck cancer patients: Evidence‐based review for the COVID‐19 era	2020-04-30		.txt	text/plain	4744	279	40	1, 2 Patients with head and neck squamous cell carcinoma (HNSCC) share common characteristics, namely upper aerodigestive tumors, advanced age, history of tobacco and alcohol abuse, and multiple cardiopulmonary comorbidities, which predispose to severe adverse respiratory outcomes. [20] [21] [22] Although data regarding the impact of prior viral outbreaks on patients with HNSCC are lacking, the decision to proceed with anti-cancer therapy, including surgery, in the current context of COVID-19 should be carefully considered given the risk of severe respiratory complications, immunosuppression, and death within this cohort. Risks of viral and bacterial pneumonia are increased among HNSCC patients receiving chemotherapy and/or radiotherapy given the presence of unique risk factors (eg, depressed immune function, older age, malnutrition, smoking and alcohol abuse, tumor location, and comorbidities). In a retrospective analysis of 374 patients who received organ preservation therapy for locally advanced HNSCC, risk factors for aspiration pneumonia included poor oral hygiene, advanced N-classification, inpatient treatment, and hypoalbuminemia.	./cache/cord-306062-g9hk1iq5.txt	./txt/cord-306062-g9hk1iq5.txt