id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-319037-77l9wdyb	Gavriilaki, Eleni	A New Era in Endothelial Injury Syndromes: Toxicity of CAR-T Cells and the Role of Immunity	2020-05-29		.txt	text/plain	6405	373	35	A novel cellular therapy in the field of autologous HCT has been recently approved in patients with hematologic malignancies: immunotherapy with chimeric antigen receptor T (CAR-T cells). Various endothelial injury syndromes result post allogeneic HCT, including transplant-associated thrombotic microangiopathy (TA-TMA), graft-versus-host disease (GVHD) and veno-occlusive disease/sinusoidal obstruction syndrome (SOS/VOD) [21] . These data are in line with a previous clinical observation documenting complement-mediated TMA in patients with hemophagocytic lymphohistiocytosis (HLH), a rare clinical syndrome of excessive immune activation, characterized by signs and symptoms of extreme inflammation, largely driven by interferon γ and other pro-inflammatory cytokines [66] . Chimeric antigen receptor ADAMTS13 a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 VWF Von Willebrand Factor CRS Cytokine release syndrome HCT Hematopoietic cell transplantation TMA Thrombotic microangiopathy B-NHL B-non-Hodgkin-lymphoma Use of Eculizumab in Patients With Allogeneic Stem Cell Transplant-Associated Thrombotic Microangiopathy: A Study From the SFGM-TC	./cache/cord-319037-77l9wdyb.txt	./txt/cord-319037-77l9wdyb.txt