id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-335802-1kiqfy68	Azoulay, Elie	Increased mortality in patients with severe SARS-CoV-2 infection admitted within seven days of disease onset	2020-08-11		.txt	text/plain	3515	194	48	METHODS: In a multicentre retrospective study, we included 379 COVID-19 patients admitted to four ICUs between 20 February and 24 April 2020 and categorised according to time from disease onset to ICU admission. To test the hypothesis that COVID-19-related critical illness differs according to time from viral symptom onset to ICU admission, we assessed patient characteristics and outcomes in a cohort of 379 critically ill patients admitted to four university-affiliated hospitals in Paris. This study collecting data from 379 COVID-19 patients showed that mortality decreased with increasing time from viral symptom onset to ICU admission. Mortality was significantly higher in patients admitted to the ICU within a week after viral symptom onset, independently from acute illness severity at ICU admission. Second, the excess mortality in patients admitted to the ICU within 7 days after viral symptom onset was associated with an increased prevalence of non-respiratory injury and, more specifically, of acute kidney and myocardial injury.	./cache/cord-335802-1kiqfy68.txt	./txt/cord-335802-1kiqfy68.txt