id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-337262-88qpfu6b	File, Thomas M.	26 Community-Acquired Pneumonia, Bacterial	2012-12-31		.txt	text/plain	3514	170	35	Abstract Community-acquired pneumonia (CAP) is defined as an acute infection of the pulmonary parenchyma in a patient who has acquired the infection in the community and has not had recent hospitalization or association with other healthcare facilities such as nursing homes, dialysis centers, and outpatient clinics. S. aureus (Figure 26 -2) and gramnegative bacilli (such as Klebsiella species; Figure 26 -3) are less frequently isolated and are the cause in selected patients (e.g., patients with severe CAP requiring intensive care admission or those who have recently received antimicrobial therapy or have pulmonary comorbidities). Therefore unless there is a specific epidemiologic factor (e.g., influenza epidemic), the empirical approach to initial therapy is usually based on the likelihood that one of the key pathogens is responsible for disease. For outpatients, empirical therapy with a macrolide, doxycycline, antipneumococcal fluoroquinolone (e.g., levofloxacin, gemifloxacin, moxifloxacin), or the combination of a β-lactam plus macrolide are recommended treatment options based on risk factors of recent antimicrobial use and comorbidities.	./cache/cord-337262-88qpfu6b.txt	./txt/cord-337262-88qpfu6b.txt