id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-339436-0k73tlna	Giagulli, Vito Angelo	Worse progression of COVID‐19 in men: Is Testosterone a key factor?	2020-06-11		.txt	text/plain	7894	520	40	Considering that low serum T levels induce detrimental effects on cardiovascular system and predispose to impaired immune response, endothelial dysfunction and systemic inflammation, respectively 28 , herein, we will overview on possible putative mechanisms by which circulating T might affect the prognosis in men with COVID-19 (Table 1) . All rights reserved adipose tissue dysfunction and male hypogonadism, even if subclinical, are associated with higher circulating levels of cytokine (IL-6, IL-1 and TNF-alpha), endothelial dysfunction 163 , and amplified thrombosis risk, possibly prompting to detrimental clinical consequences in case of SARS-CoV-2 infection. It may affect baseline respiratory function, thus increasing the risk of mechanical ventilation requirement once the infection occurred; increase the number of baseline comorbidities, consequently predisposing to poor prognosis or death as certificated by epidemiological studies; fosters hormonal imbalance (decline in circulating serum T and increase in serum estrogen concentration) which are involved in the fine regulation of immune system and coagulative homeostasis in case of infection, and predispose men to poor effective immune response, cytokine dysregulation; endothelial dysfunction and thrombosis.	./cache/cord-339436-0k73tlna.txt	./txt/cord-339436-0k73tlna.txt