id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-355033-txxylmrw	frontera, Jennifer A.	Treatment with Zinc is Associated with Reduced In-Hospital Mortality Among COVID-19 Patients: A Multi-Center Cohort Study	2020-10-26		.txt	text/plain	4271	204	46	Patients who received Zn+ionophore were compared to patients who did not using multivariable time-dependent cox proportional hazards models for time to in-hospital death adjusting for confounders including age, sex, race, BMI, diabetes, week of admission, hospital location, sequential organ failure assessment (SOFA) score, intubation, acute renal failure, neurological events, treatment with corticosteroids, azithromycin or lopinavir/ritonavir and the propensity score of receiving Zn+ionophore. This model was adjusted for confounders including age, sex, race, body mass index (BMI), diabetes, week of admission, hospital location, maximum sequential organ failure assessment (SOFA) score recorded during hospitalization, intubation/invasive mechanical ventilation, acute renal failure, neurological complications, treatment with corticosteroids, azithromycin or lopinavir/ritonavir and the propensity score for receiving Zn + ionophore. In this large cohort study with propensity score-matched sensitivity analysis, we evaluated the a priori hypothesis based on biologic plausibility, that treatment with zinc along with an ionophore (which increases intracellular zinc levels) would have a bene cial impact on patients with COVID-19.	./cache/cord-355033-txxylmrw.txt	./txt/cord-355033-txxylmrw.txt