id	sid	tid	token	lemma	pos
cord-012902-efprpk72	1	1	key	key	NN
cord-012902-efprpk72	1	2	:	:	:
cord-012902-efprpk72	2	1	cord-012902-efprpk72	cord-012902-efprpk72	IN
cord-012902-efprpk72	3	1	authors	author	NNS
cord-012902-efprpk72	3	2	:	:	:
cord-012902-efprpk72	4	1	nan	nan	NNP
cord-012902-efprpk72	4	2	title	title	NN
cord-012902-efprpk72	4	3	:	:	:
cord-012902-efprpk72	4	4	Abstracts	abstract	NNS
cord-012902-efprpk72	4	5	from	from	IN
cord-012902-efprpk72	4	6	the	the	DT
cord-012902-efprpk72	4	7	2020	2020	CD
cord-012902-efprpk72	4	8	Annual	Annual	NNP
cord-012902-efprpk72	4	9	Scientific	Scientific	NNP
cord-012902-efprpk72	4	10	Meeting	Meeting	NNP
cord-012902-efprpk72	4	11	of	of	IN
cord-012902-efprpk72	4	12	the	the	DT
cord-012902-efprpk72	4	13	British	british	JJ
cord-012902-efprpk72	4	14	and	and	CC
cord-012902-efprpk72	4	15	Irish	irish	JJ
cord-012902-efprpk72	4	16	Hypertension	Hypertension	NNP
cord-012902-efprpk72	4	17	Society	Society	NNP
cord-012902-efprpk72	4	18	(	(	-LRB-
cord-012902-efprpk72	4	19	BIHS	BIHS	NNP
cord-012902-efprpk72	4	20	)	)	-RRB-
cord-012902-efprpk72	4	21	date	date	NN
cord-012902-efprpk72	4	22	:	:	:
cord-012902-efprpk72	4	23	2020	2020	CD
cord-012902-efprpk72	4	24	-	-	HYPH
cord-012902-efprpk72	4	25	09	09	CD
cord-012902-efprpk72	4	26	-	-	SYM
cord-012902-efprpk72	4	27	15	15	CD
cord-012902-efprpk72	4	28	journal	journal	NN
cord-012902-efprpk72	4	29	:	:	:
cord-012902-efprpk72	5	1	J	J	NNP
cord-012902-efprpk72	5	2	Hum	Hum	NNP
cord-012902-efprpk72	5	3	Hypertens	Hypertens	NNP
cord-012902-efprpk72	5	4	DOI	doi	NN
cord-012902-efprpk72	5	5	:	:	:
cord-012902-efprpk72	6	1	10.1038	10.1038	CD
cord-012902-efprpk72	6	2	/	/	SYM
cord-012902-efprpk72	6	3	s41371	s41371	NNP
cord-012902-efprpk72	6	4	-	-	HYPH
cord-012902-efprpk72	6	5	020	020	CD
cord-012902-efprpk72	6	6	-	-	HYPH
cord-012902-efprpk72	6	7	00410	00410	CD
cord-012902-efprpk72	6	8	-	-	SYM
cord-012902-efprpk72	6	9	6	6	CD
cord-012902-efprpk72	6	10	sha	sha	NN
cord-012902-efprpk72	6	11	:	:	:
cord-012902-efprpk72	6	12	719c5c7dd8dcc6c42e29c3ebff380e97db50e5b6	719c5c7dd8dcc6c42e29c3ebff380e97db50e5b6	.
cord-012902-efprpk72	6	13	doc_id	doc_id	CD
cord-012902-efprpk72	6	14	:	:	:
cord-012902-efprpk72	6	15	12902	12902	CD
cord-012902-efprpk72	6	16	cord_uid	cord_uid	NNS
cord-012902-efprpk72	6	17	:	:	:
cord-012902-efprpk72	6	18	efprpk72	efprpk72	.
cord-012902-efprpk72	7	1	nan	nan	NNP
cord-012902-efprpk72	7	2	Introduction	Introduction	NNP
cord-012902-efprpk72	7	3	:	:	:
cord-012902-efprpk72	8	1	Our	-PRON-	PRP$
cord-012902-efprpk72	8	2	previous	previous	JJ
cord-012902-efprpk72	8	3	genome	genome	NN
cord-012902-efprpk72	8	4	wide	wide	JJ
cord-012902-efprpk72	8	5	association	association	NN
cord-012902-efprpk72	8	6	study	study	NN
cord-012902-efprpk72	8	7	(	(	-LRB-
cord-012902-efprpk72	8	8	GWAS	GWAS	NNP
cord-012902-efprpk72	8	9	)	)	-RRB-
cord-012902-efprpk72	8	10	highlighted	highlight	VBD
cord-012902-efprpk72	8	11	a	a	DT
cord-012902-efprpk72	8	12	locus	locus	NN
cord-012902-efprpk72	8	13	on	on	IN
cord-012902-efprpk72	8	14	the	the	DT
cord-012902-efprpk72	8	15	promoter	promoter	NN
cord-012902-efprpk72	8	16	of	of	IN
cord-012902-efprpk72	8	17	the	the	DT
cord-012902-efprpk72	8	18	human	human	JJ
cord-012902-efprpk72	8	19	uromodulin	uromodulin	NN
cord-012902-efprpk72	8	20	(	(	-LRB-
cord-012902-efprpk72	8	21	UMOD	UMOD	NNP
cord-012902-efprpk72	8	22	)	)	-RRB-
cord-012902-efprpk72	8	23	gene	gene	NN
cord-012902-efprpk72	8	24	,	,	,
cord-012902-efprpk72	8	25	associated	associate	VBN
cord-012902-efprpk72	8	26	with	with	IN
cord-012902-efprpk72	8	27	hypertension	hypertension	NN
cord-012902-efprpk72	8	28	.	.	.
cord-012902-efprpk72	9	1	In	in	IN
cord-012902-efprpk72	9	2	this	this	DT
cord-012902-efprpk72	9	3	study	study	NN
cord-012902-efprpk72	9	4	,	,	,
cord-012902-efprpk72	9	5	we	-PRON-	PRP
cord-012902-efprpk72	9	6	sought	seek	VBD
cord-012902-efprpk72	9	7	to	to	TO
cord-012902-efprpk72	9	8	identify	identify	VB
cord-012902-efprpk72	9	9	potential	potential	JJ
cord-012902-efprpk72	9	10	pathways	pathway	NNS
cord-012902-efprpk72	9	11	which	which	WDT
cord-012902-efprpk72	9	12	facilitate	facilitate	VBP
cord-012902-efprpk72	9	13	the	the	DT
cord-012902-efprpk72	9	14	association	association	NN
cord-012902-efprpk72	9	15	of	of	IN
cord-012902-efprpk72	9	16	UMOD	UMOD	NNP
cord-012902-efprpk72	9	17	with	with	IN
cord-012902-efprpk72	9	18	blood	blood	NN
cord-012902-efprpk72	9	19	pressure	pressure	NN
cord-012902-efprpk72	9	20	through	through	IN
cord-012902-efprpk72	9	21	effects	effect	NNS
cord-012902-efprpk72	9	22	on	on	IN
cord-012902-efprpk72	9	23	gene	gene	NN
cord-012902-efprpk72	9	24	expression	expression	NN
cord-012902-efprpk72	9	25	.	.	.
cord-012902-efprpk72	10	1	Methods	method	NNS
cord-012902-efprpk72	10	2	:	:	:
cord-012902-efprpk72	10	3	From	from	IN
cord-012902-efprpk72	10	4	our	-PRON-	PRP$
cord-012902-efprpk72	10	5	bank	bank	NN
cord-012902-efprpk72	10	6	of	of	IN
cord-012902-efprpk72	10	7	98	98	CD
cord-012902-efprpk72	10	8	human	human	JJ
cord-012902-efprpk72	10	9	renal	renal	JJ
cord-012902-efprpk72	10	10	biopsy	biopsy	NN
cord-012902-efprpk72	10	11	samples	sample	NNS
cord-012902-efprpk72	10	12	,	,	,
cord-012902-efprpk72	10	13	we	-PRON-	PRP
cord-012902-efprpk72	10	14	assessed	assess	VBD
cord-012902-efprpk72	10	15	UMOD	UMOD	NNP
cord-012902-efprpk72	10	16	and	and	CC
cord-012902-efprpk72	10	17	NKCC2	nkcc2	NN
cord-012902-efprpk72	10	18	expression	expression	NN
cord-012902-efprpk72	10	19	by	by	IN
cord-012902-efprpk72	10	20	qRT	qRT	NNP
cord-012902-efprpk72	10	21	-	-	HYPH
cord-012902-efprpk72	10	22	PCR	PCR	NNP
cord-012902-efprpk72	10	23	.	.	.
cord-012902-efprpk72	11	1	Individuals	individual	NNS
cord-012902-efprpk72	11	2	were	be	VBD
cord-012902-efprpk72	11	3	stratified	stratify	VBN
cord-012902-efprpk72	11	4	by	by	IN
cord-012902-efprpk72	11	5	UMOD	umod	JJ
cord-012902-efprpk72	11	6	expression	expression	NN
cord-012902-efprpk72	11	7	and	and	CC
cord-012902-efprpk72	11	8	RNA	rna	NN
cord-012902-efprpk72	11	9	-	-	HYPH
cord-012902-efprpk72	11	10	sequencing	sequencing	NN
cord-012902-efprpk72	11	11	using	use	VBG
cord-012902-efprpk72	11	12	the	the	DT
cord-012902-efprpk72	11	13	NextSeq-500	NextSeq-500	NNP
cord-012902-efprpk72	11	14	system	system	NN
cord-012902-efprpk72	11	15	performed	perform	VBN
cord-012902-efprpk72	11	16	on	on	IN
cord-012902-efprpk72	11	17	a	a	DT
cord-012902-efprpk72	11	18	subset	subset	NN
cord-012902-efprpk72	11	19	of	of	IN
cord-012902-efprpk72	11	20	high	high	JJ
cord-012902-efprpk72	11	21	and	and	CC
cord-012902-efprpk72	11	22	low	low	JJ
cord-012902-efprpk72	11	23	UMOD	UMOD	NNP
cord-012902-efprpk72	11	24	expression	expression	NN
cord-012902-efprpk72	11	25	(	(	-LRB-
cord-012902-efprpk72	11	26	n	n	NN
cord-012902-efprpk72	11	27	=	=	SYM
cord-012902-efprpk72	11	28	3/	3/	CD
cord-012902-efprpk72	11	29	group	group	NN
cord-012902-efprpk72	11	30	)	)	-RRB-
cord-012902-efprpk72	11	31	.	.	.
cord-012902-efprpk72	12	1	Differential	differential	JJ
cord-012902-efprpk72	12	2	expression	expression	NN
cord-012902-efprpk72	12	3	was	be	VBD
cord-012902-efprpk72	12	4	assessed	assess	VBN
cord-012902-efprpk72	12	5	by	by	IN
cord-012902-efprpk72	12	6	DESeq2	DESeq2	NNP
cord-012902-efprpk72	12	7	to	to	TO
cord-012902-efprpk72	12	8	detect	detect	VB
cord-012902-efprpk72	12	9	significant	significant	JJ
cord-012902-efprpk72	12	10	differences	difference	NNS
cord-012902-efprpk72	12	11	(	(	-LRB-
cord-012902-efprpk72	12	12	p	p	IN
cord-012902-efprpk72	12	13	[	[	-LRB-
cord-012902-efprpk72	12	14	adjusted	adjust	VBN
cord-012902-efprpk72	12	15	]	]	-RRB-
cord-012902-efprpk72	12	16	<	<	XX
cord-012902-efprpk72	12	17	0.05	0.05	CD
cord-012902-efprpk72	12	18	)	)	-RRB-
cord-012902-efprpk72	12	19	in	in	IN
cord-012902-efprpk72	12	20	the	the	DT
cord-012902-efprpk72	12	21	transcriptome	transcriptome	NN
cord-012902-efprpk72	12	22	between	between	IN
cord-012902-efprpk72	12	23	high	high	JJ
cord-012902-efprpk72	12	24	and	and	CC
cord-012902-efprpk72	12	25	low	low	JJ
cord-012902-efprpk72	12	26	UMOD	UMOD	NNP
cord-012902-efprpk72	12	27	expressers	expresser	NNS
cord-012902-efprpk72	12	28	and	and	CC
cord-012902-efprpk72	12	29	pathways	pathway	NNS
cord-012902-efprpk72	12	30	visualised	visualise	VBD
cord-012902-efprpk72	12	31	using	use	VBG
cord-012902-efprpk72	12	32	Ingenuity	Ingenuity	NNP
cord-012902-efprpk72	12	33	Pathway	Pathway	NNP
cord-012902-efprpk72	12	34	Analysis	Analysis	NNP
cord-012902-efprpk72	12	35	(	(	-LRB-
cord-012902-efprpk72	12	36	IPA	IPA	NNP
cord-012902-efprpk72	12	37	)	)	-RRB-
cord-012902-efprpk72	12	38	.	.	.
cord-012902-efprpk72	13	1	Results	result	NNS
cord-012902-efprpk72	13	2	:	:	:
cord-012902-efprpk72	14	1	RNA	RNA	NNP
cord-012902-efprpk72	14	2	-	-	HYPH
cord-012902-efprpk72	14	3	Seq	Seq	NNP
cord-012902-efprpk72	14	4	identified	identify	VBD
cord-012902-efprpk72	14	5	162	162	CD
cord-012902-efprpk72	14	6	differentially	differentially	RB
cord-012902-efprpk72	14	7	expressed	express	VBN
cord-012902-efprpk72	14	8	genes	gene	NNS
cord-012902-efprpk72	14	9	(	(	-LRB-
cord-012902-efprpk72	14	10	138	138	CD
cord-012902-efprpk72	14	11	protein	protein	NN
cord-012902-efprpk72	14	12	coding	code	VBG
cord-012902-efprpk72	14	13	genes,18	genes,18	JJ
cord-012902-efprpk72	14	14	long	long	JJ
cord-012902-efprpk72	14	15	non	non	JJ
cord-012902-efprpk72	14	16	-	-	JJ
cord-012902-efprpk72	14	17	coding	coding	JJ
cord-012902-efprpk72	14	18	RNAs	rna	NNS
cord-012902-efprpk72	14	19	and	and	CC
cord-012902-efprpk72	14	20	8	8	CD
cord-012902-efprpk72	14	21	additional	additional	JJ
cord-012902-efprpk72	14	22	transcriptomic	transcriptomic	JJ
cord-012902-efprpk72	14	23	elements	element	NNS
cord-012902-efprpk72	14	24	)	)	-RRB-
cord-012902-efprpk72	14	25	,	,	,
cord-012902-efprpk72	14	26	of	of	IN
cord-012902-efprpk72	14	27	these	these	DT
cord-012902-efprpk72	14	28	,	,	,
cord-012902-efprpk72	14	29	123	123	CD
cord-012902-efprpk72	14	30	genes	gene	NNS
cord-012902-efprpk72	14	31	increased	increase	VBD
cord-012902-efprpk72	14	32	in	in	IN
cord-012902-efprpk72	14	33	expression	expression	NN
cord-012902-efprpk72	14	34	with	with	IN
cord-012902-efprpk72	14	35	high	high	JJ
cord-012902-efprpk72	14	36	UMOD	UMOD	NNP
cord-012902-efprpk72	14	37	expression	expression	NN
cord-012902-efprpk72	14	38	.	.	.
cord-012902-efprpk72	15	1	Using	use	VBG
cord-012902-efprpk72	15	2	IPA	IPA	NNP
cord-012902-efprpk72	15	3	,	,	,
cord-012902-efprpk72	15	4	we	-PRON-	PRP
cord-012902-efprpk72	15	5	detected	detect	VBD
cord-012902-efprpk72	15	6	enrichment	enrichment	NN
cord-012902-efprpk72	15	7	for	for	IN
cord-012902-efprpk72	15	8	pathways	pathway	NNS
cord-012902-efprpk72	15	9	related	relate	VBN
cord-012902-efprpk72	15	10	to	to	IN
cord-012902-efprpk72	15	11	immune	immune	JJ
cord-012902-efprpk72	15	12	system	system	NN
cord-012902-efprpk72	15	13	function	function	NN
cord-012902-efprpk72	15	14	,	,	,
cord-012902-efprpk72	15	15	cell	cell	NN
cord-012902-efprpk72	15	16	to	to	IN
cord-012902-efprpk72	15	17	cell	cell	NN
cord-012902-efprpk72	15	18	communication	communication	NN
cord-012902-efprpk72	15	19	and	and	CC
cord-012902-efprpk72	15	20	molecular	molecular	JJ
cord-012902-efprpk72	15	21	ion	ion	NN
cord-012902-efprpk72	15	22	transport	transport	NN
cord-012902-efprpk72	15	23	.	.	.
cord-012902-efprpk72	16	1	Notably	notably	RB
cord-012902-efprpk72	16	2	,	,	,
cord-012902-efprpk72	16	3	we	-PRON-	PRP
cord-012902-efprpk72	16	4	show	show	VBP
cord-012902-efprpk72	16	5	that	that	IN
cord-012902-efprpk72	16	6	an	an	DT
cord-012902-efprpk72	16	7	increase	increase	NN
cord-012902-efprpk72	16	8	in	in	IN
cord-012902-efprpk72	16	9	UMOD	UMOD	NNP
cord-012902-efprpk72	16	10	expression	expression	NN
cord-012902-efprpk72	16	11	associates	associate	NNS
cord-012902-efprpk72	16	12	with	with	IN
cord-012902-efprpk72	16	13	an	an	DT
cord-012902-efprpk72	16	14	increase	increase	NN
cord-012902-efprpk72	16	15	in	in	IN
cord-012902-efprpk72	16	16	expression	expression	NN
cord-012902-efprpk72	16	17	of	of	IN
cord-012902-efprpk72	16	18	the	the	DT
cord-012902-efprpk72	16	19	Na	Na	NNP
cord-012902-efprpk72	16	20	-	-	HYPH
cord-012902-efprpk72	16	21	K	K	NNP
cord-012902-efprpk72	16	22	-	-	HYPH
cord-012902-efprpk72	16	23	Cl	Cl	NNP
cord-012902-efprpk72	16	24	cotransporter	cotransporter	NN
cord-012902-efprpk72	16	25	(	(	-LRB-
cord-012902-efprpk72	16	26	NKCC2	NKCC2	NNP
cord-012902-efprpk72	16	27	)	)	-RRB-
cord-012902-efprpk72	16	28	(	(	-LRB-
cord-012902-efprpk72	16	29	p	p	IN
cord-012902-efprpk72	16	30	[	[	-LRB-
cord-012902-efprpk72	16	31	adjusted	adjust	VBN
cord-012902-efprpk72	16	32	]	]	-RRB-
cord-012902-efprpk72	16	33	=	=	NFP
cord-012902-efprpk72	17	1	2.58e−9	2.58e−9	CD
cord-012902-efprpk72	17	2	,	,	,
cord-012902-efprpk72	17	3	FC	FC	NNP
cord-012902-efprpk72	17	4	=	=	SYM
cord-012902-efprpk72	17	5	10.89	10.89	CD
cord-012902-efprpk72	17	6	)	)	-RRB-
cord-012902-efprpk72	17	7	,	,	,
cord-012902-efprpk72	17	8	the	the	DT
cord-012902-efprpk72	17	9	renal	renal	JJ
cord-012902-efprpk72	17	10	outer	outer	JJ
cord-012902-efprpk72	17	11	medullary	medullary	JJ
cord-012902-efprpk72	17	12	potassium	potassium	NN
cord-012902-efprpk72	17	13	channel	channel	NN
cord-012902-efprpk72	17	14	(	(	-LRB-
cord-012902-efprpk72	17	15	ROMK	ROMK	NNP
cord-012902-efprpk72	17	16	)	)	-RRB-
cord-012902-efprpk72	18	1	(	(	-LRB-
cord-012902-efprpk72	18	2	p	p	IN
cord-012902-efprpk72	18	3	[	[	-LRB-
cord-012902-efprpk72	18	4	adjusted	adjust	VBN
cord-012902-efprpk72	18	5	]	]	-RRB-
cord-012902-efprpk72	18	6	=	=	NFP
cord-012902-efprpk72	19	1	3.69e−2	3.69e−2	CD
cord-012902-efprpk72	19	2	,	,	,
cord-012902-efprpk72	19	3	FC	FC	NNP
cord-012902-efprpk72	19	4	=	=	SYM
cord-012902-efprpk72	19	5	2.79	2.79	CD
cord-012902-efprpk72	19	6	)	)	-RRB-
cord-012902-efprpk72	19	7	and	and	CC
cord-012902-efprpk72	19	8	the	the	DT
cord-012902-efprpk72	19	9	γsubunit	γsubunit	NN
cord-012902-efprpk72	19	10	of	of	IN
cord-012902-efprpk72	19	11	the	the	DT
cord-012902-efprpk72	19	12	epithelial	epithelial	JJ
cord-012902-efprpk72	19	13	sodium	sodium	NN
cord-012902-efprpk72	19	14	channel	channel	NN
cord-012902-efprpk72	19	15	(	(	-LRB-
cord-012902-efprpk72	19	16	ENaC	ENaC	NNP
cord-012902-efprpk72	19	17	)	)	-RRB-
cord-012902-efprpk72	20	1	(	(	-LRB-
cord-012902-efprpk72	20	2	p	p	IN
cord-012902-efprpk72	20	3	[	[	-LRB-
cord-012902-efprpk72	20	4	adjusted	adjust	VBN
cord-012902-efprpk72	20	5	]	]	-RRB-
cord-012902-efprpk72	20	6	=	=	NFP
cord-012902-efprpk72	21	1	1.83e−2	1.83e−2	CD
cord-012902-efprpk72	21	2	,	,	,
cord-012902-efprpk72	21	3	FC	FC	NNP
cord-012902-efprpk72	21	4	=	=	SYM
cord-012902-efprpk72	21	5	1.25	1.25	CD
cord-012902-efprpk72	21	6	)	)	-RRB-
cord-012902-efprpk72	21	7	.	.	.
cord-012902-efprpk72	22	1	We	-PRON-	PRP
cord-012902-efprpk72	22	2	further	further	RB
cord-012902-efprpk72	22	3	validated	validate	VBD
cord-012902-efprpk72	22	4	the	the	DT
cord-012902-efprpk72	22	5	relationship	relationship	NN
cord-012902-efprpk72	22	6	between	between	IN
cord-012902-efprpk72	22	7	UMOD	UMOD	NNP
cord-012902-efprpk72	22	8	and	and	CC
cord-012902-efprpk72	22	9	NKCC2	nkcc2	NN
cord-012902-efprpk72	22	10	,	,	,
cord-012902-efprpk72	22	11	by	by	IN
cord-012902-efprpk72	22	12	Taqman	Taqman	NNP
cord-012902-efprpk72	22	13	qRT	qRT	NNP
cord-012902-efprpk72	22	14	-	-	HYPH
cord-012902-efprpk72	22	15	PCR	PCR	NNP
cord-012902-efprpk72	22	16	,	,	,
cord-012902-efprpk72	22	17	showing	show	VBG
cord-012902-efprpk72	22	18	a	a	DT
cord-012902-efprpk72	22	19	highly	highly	RB
cord-012902-efprpk72	22	20	significant	significant	JJ
cord-012902-efprpk72	22	21	correlation	correlation	NN
cord-012902-efprpk72	22	22	of	of	IN
cord-012902-efprpk72	22	23	expression	expression	NN
cord-012902-efprpk72	22	24	(	(	-LRB-
cord-012902-efprpk72	22	25	p	p	NN
cord-012902-efprpk72	22	26	=	=	SYM
cord-012902-efprpk72	22	27	2.2e−16	2.2e−16	CD
cord-012902-efprpk72	22	28	,	,	,
cord-012902-efprpk72	22	29	R	r	NN
cord-012902-efprpk72	22	30	=	=	SYM
cord-012902-efprpk72	22	31	0.844	0.844	CD
cord-012902-efprpk72	22	32	)	)	-RRB-
cord-012902-efprpk72	23	1	(	(	-LRB-
cord-012902-efprpk72	23	2	n	n	NN
cord-012902-efprpk72	23	3	=	=	SYM
cord-012902-efprpk72	23	4	86	86	CD
cord-012902-efprpk72	23	5	)	)	-RRB-
cord-012902-efprpk72	23	6	.	.	.
cord-012902-efprpk72	24	1	Conclusions	conclusion	NNS
cord-012902-efprpk72	24	2	:	:	:
cord-012902-efprpk72	25	1	Of	of	IN
cord-012902-efprpk72	25	2	several	several	JJ
cord-012902-efprpk72	25	3	pathways	pathway	NNS
cord-012902-efprpk72	25	4	identified	identify	VBN
cord-012902-efprpk72	25	5	by	by	IN
cord-012902-efprpk72	25	6	IPA	IPA	NNP
cord-012902-efprpk72	25	7	,	,	,
cord-012902-efprpk72	25	8	association	association	NN
cord-012902-efprpk72	25	9	of	of	IN
cord-012902-efprpk72	25	10	UMOD	UMOD	NNP
cord-012902-efprpk72	25	11	expression	expression	NN
cord-012902-efprpk72	25	12	with	with	IN
cord-012902-efprpk72	25	13	expression	expression	NN
cord-012902-efprpk72	25	14	of	of	IN
cord-012902-efprpk72	25	15	these	these	DT
cord-012902-efprpk72	25	16	three	three	CD
cord-012902-efprpk72	25	17	ion	ion	NN
cord-012902-efprpk72	25	18	channels	channel	NNS
cord-012902-efprpk72	25	19	(	(	-LRB-
cord-012902-efprpk72	25	20	NKCC2	NKCC2	NNP
cord-012902-efprpk72	25	21	,	,	,
cord-012902-efprpk72	25	22	ROMK	ROMK	NNP
cord-012902-efprpk72	25	23	and	and	CC
cord-012902-efprpk72	25	24	ENaC	ENaC	NNP
cord-012902-efprpk72	25	25	)	)	-RRB-
cord-012902-efprpk72	25	26	may	may	MD
cord-012902-efprpk72	25	27	explain	explain	VB
cord-012902-efprpk72	25	28	previously	previously	RB
cord-012902-efprpk72	25	29	observed	observe	VBN
cord-012902-efprpk72	25	30	relationship	relationship	NN
cord-012902-efprpk72	25	31	between	between	IN
cord-012902-efprpk72	25	32	UMOD	umod	NN
cord-012902-efprpk72	25	33	and	and	CC
cord-012902-efprpk72	25	34	blood	blood	NN
cord-012902-efprpk72	25	35	pressure	pressure	NN
cord-012902-efprpk72	25	36	.	.	.
cord-012902-efprpk72	26	1	These	these	DT
cord-012902-efprpk72	26	2	data	datum	NNS
cord-012902-efprpk72	26	3	suggest	suggest	VBP
cord-012902-efprpk72	26	4	the	the	DT
cord-012902-efprpk72	26	5	UMOD	UMOD	NNP
cord-012902-efprpk72	26	6	:	:	:
cord-012902-efprpk72	27	1	iontransport	iontransport	NNP
cord-012902-efprpk72	27	2	pathway	pathway	NNP
cord-012902-efprpk72	27	3	may	may	MD
cord-012902-efprpk72	27	4	be	be	VB
cord-012902-efprpk72	27	5	a	a	DT
cord-012902-efprpk72	27	6	drug	drug	NN
cord-012902-efprpk72	27	7	target	target	NN
cord-012902-efprpk72	27	8	in	in	IN
cord-012902-efprpk72	27	9	the	the	DT
cord-012902-efprpk72	27	10	treatment	treatment	NN
cord-012902-efprpk72	27	11	of	of	IN
cord-012902-efprpk72	27	12	hypertension	hypertension	NN
cord-012902-efprpk72	27	13	.	.	.
cord-012902-efprpk72	28	1	Disclosures	disclosure	NNS
cord-012902-efprpk72	28	2	:	:	:
cord-012902-efprpk72	28	3	None	none	NN
cord-012902-efprpk72	28	4	.	.	.
cord-012902-efprpk72	29	1	Introduction	introduction	NN
cord-012902-efprpk72	29	2	:	:	:
cord-012902-efprpk72	29	3	Left	leave	VBN
cord-012902-efprpk72	29	4	ventricular	ventricular	JJ
cord-012902-efprpk72	29	5	mass	mass	NN
cord-012902-efprpk72	29	6	(	(	-LRB-
cord-012902-efprpk72	29	7	LVM	LVM	NNP
cord-012902-efprpk72	29	8	)	)	-RRB-
cord-012902-efprpk72	29	9	is	be	VBZ
cord-012902-efprpk72	29	10	a	a	DT
cord-012902-efprpk72	29	11	strong	strong	JJ
cord-012902-efprpk72	29	12	predictor	predictor	NN
cord-012902-efprpk72	29	13	of	of	IN
cord-012902-efprpk72	29	14	CV	CV	NNP
cord-012902-efprpk72	29	15	risk	risk	NN
cord-012902-efprpk72	29	16	.	.	.
cord-012902-efprpk72	30	1	Adiposity	Adiposity	NNP
cord-012902-efprpk72	30	2	affects	affect	VBZ
cord-012902-efprpk72	30	3	LVM	LVM	NNP
cord-012902-efprpk72	30	4	but	but	CC
cord-012902-efprpk72	30	5	the	the	DT
cord-012902-efprpk72	30	6	extent	extent	NN
cord-012902-efprpk72	30	7	to	to	TO
cord-012902-efprpk72	30	8	which	which	WDT
cord-012902-efprpk72	30	9	other	other	JJ
cord-012902-efprpk72	30	10	cardiovascular	cardiovascular	JJ
cord-012902-efprpk72	30	11	risk	risk	NN
cord-012902-efprpk72	30	12	factors	factor	NNS
cord-012902-efprpk72	30	13	mediate	mediate	VBP
cord-012902-efprpk72	30	14	this	this	DT
cord-012902-efprpk72	30	15	association	association	NN
cord-012902-efprpk72	30	16	is	be	VBZ
cord-012902-efprpk72	30	17	unclear	unclear	JJ
cord-012902-efprpk72	30	18	and	and	CC
cord-012902-efprpk72	30	19	has	have	VBZ
cord-012902-efprpk72	30	20	not	not	RB
cord-012902-efprpk72	30	21	been	be	VBN
cord-012902-efprpk72	30	22	studied	study	VBN
cord-012902-efprpk72	30	23	in	in	IN
cord-012902-efprpk72	30	24	the	the	DT
cord-012902-efprpk72	30	25	transition	transition	NN
cord-012902-efprpk72	30	26	from	from	IN
cord-012902-efprpk72	30	27	adolescence	adolescence	NN
cord-012902-efprpk72	30	28	to	to	IN
cord-012902-efprpk72	30	29	emerging	emerge	VBG
cord-012902-efprpk72	30	30	adulthood	adulthood	NN
cord-012902-efprpk72	30	31	.	.	.
cord-012902-efprpk72	31	1	We	-PRON-	PRP
cord-012902-efprpk72	31	2	investigated	investigate	VBD
cord-012902-efprpk72	31	3	mediation	mediation	NN
cord-012902-efprpk72	31	4	by	by	IN
cord-012902-efprpk72	31	5	blood	blood	NN
cord-012902-efprpk72	31	6	pressure	pressure	NN
cord-012902-efprpk72	31	7	(	(	-LRB-
cord-012902-efprpk72	31	8	BP	BP	NNP
cord-012902-efprpk72	31	9	)	)	-RRB-
cord-012902-efprpk72	31	10	and	and	CC
cord-012902-efprpk72	31	11	other	other	JJ
cord-012902-efprpk72	31	12	biomarkers	biomarker	NNS
cord-012902-efprpk72	31	13	in	in	IN
cord-012902-efprpk72	31	14	associations	association	NNS
cord-012902-efprpk72	31	15	between	between	IN
cord-012902-efprpk72	31	16	fat	fat	JJ
cord-012902-efprpk72	31	17	mass	mass	NN
cord-012902-efprpk72	31	18	and	and	CC
cord-012902-efprpk72	31	19	LVM	LVM	NNP
cord-012902-efprpk72	31	20	in	in	IN
cord-012902-efprpk72	31	21	participants	participant	NNS
cord-012902-efprpk72	31	22	of	of	IN
cord-012902-efprpk72	31	23	the	the	DT
cord-012902-efprpk72	31	24	ALSPAC	ALSPAC	NNP
cord-012902-efprpk72	31	25	study	study	NN
cord-012902-efprpk72	31	26	.	.	.
cord-012902-efprpk72	32	1	Methods	method	NNS
cord-012902-efprpk72	32	2	:	:	:
cord-012902-efprpk72	32	3	Body	body	NN
cord-012902-efprpk72	32	4	composition	composition	NN
cord-012902-efprpk72	32	5	was	be	VBD
cord-012902-efprpk72	32	6	assessed	assess	VBN
cord-012902-efprpk72	32	7	using	use	VBG
cord-012902-efprpk72	32	8	dual	dual	JJ
cord-012902-efprpk72	32	9	energy	energy	NN
cord-012902-efprpk72	32	10	X	x	NN
cord-012902-efprpk72	32	11	-	-	NN
cord-012902-efprpk72	32	12	ray	ray	NN
cord-012902-efprpk72	32	13	absorptiometry	absorptiometry	NN
cord-012902-efprpk72	32	14	(	(	-LRB-
cord-012902-efprpk72	32	15	DXA	DXA	NNP
cord-012902-efprpk72	32	16	)	)	-RRB-
cord-012902-efprpk72	32	17	in	in	IN
cord-012902-efprpk72	32	18	912	912	CD
cord-012902-efprpk72	32	19	individuals	individual	NNS
cord-012902-efprpk72	32	20	(	(	-LRB-
cord-012902-efprpk72	32	21	61	61	CD
cord-012902-efprpk72	32	22	%	%	NN
cord-012902-efprpk72	32	23	female	female	NN
cord-012902-efprpk72	32	24	)	)	-RRB-
cord-012902-efprpk72	32	25	at	at	IN
cord-012902-efprpk72	32	26	ages	age	NNS
cord-012902-efprpk72	32	27	17.7(SD	17.7(sd	CD
cord-012902-efprpk72	32	28	0.30	0.30	CD
cord-012902-efprpk72	32	29	)	)	-RRB-
cord-012902-efprpk72	33	1	(	(	-LRB-
cord-012902-efprpk72	33	2	weight	weight	NN
cord-012902-efprpk72	33	3	65(SD	65(sd	CD
cord-012902-efprpk72	33	4	12	12	CD
cord-012902-efprpk72	33	5	)	)	-RRB-
cord-012902-efprpk72	33	6	kg	kg	NNP
cord-012902-efprpk72	33	7	)	)	-RRB-
cord-012902-efprpk72	33	8	and	and	CC
cord-012902-efprpk72	33	9	24.01	24.01	CD
cord-012902-efprpk72	33	10	(	(	-LRB-
cord-012902-efprpk72	33	11	SD	sd	NN
cord-012902-efprpk72	33	12	0.57	0.57	CD
cord-012902-efprpk72	33	13	)	)	-RRB-
cord-012902-efprpk72	33	14	years	year	NNS
cord-012902-efprpk72	34	1	(	(	-LRB-
cord-012902-efprpk72	34	2	weight	weight	NN
cord-012902-efprpk72	34	3	71	71	CD
cord-012902-efprpk72	34	4	(	(	-LRB-
cord-012902-efprpk72	34	5	SD	SD	NNP
cord-012902-efprpk72	34	6	14	14	CD
cord-012902-efprpk72	34	7	)	)	-RRB-
cord-012902-efprpk72	34	8	kg	kg	NNP
cord-012902-efprpk72	34	9	)	)	-RRB-
cord-012902-efprpk72	34	10	.	.	.
cord-012902-efprpk72	35	1	BP	BP	NNP
cord-012902-efprpk72	35	2	was	be	VBD
cord-012902-efprpk72	35	3	measured	measure	VBN
cord-012902-efprpk72	35	4	and	and	CC
cord-012902-efprpk72	35	5	echocardiography	echocardiography	NN
cord-012902-efprpk72	35	6	and	and	CC
cord-012902-efprpk72	35	7	blood	blood	NN
cord-012902-efprpk72	35	8	assays	assay	NNS
cord-012902-efprpk72	35	9	were	be	VBD
cord-012902-efprpk72	35	10	performed	perform	VBN
cord-012902-efprpk72	35	11	.	.	.
cord-012902-efprpk72	36	1	Structural	structural	JJ
cord-012902-efprpk72	36	2	equation	equation	NN
cord-012902-efprpk72	36	3	modelling	modelling	NN
cord-012902-efprpk72	36	4	was	be	VBD
cord-012902-efprpk72	36	5	used	use	VBN
cord-012902-efprpk72	36	6	to	to	TO
cord-012902-efprpk72	36	7	assess	assess	VB
cord-012902-efprpk72	36	8	possible	possible	JJ
cord-012902-efprpk72	36	9	mediation	mediation	NN
cord-012902-efprpk72	36	10	by	by	IN
cord-012902-efprpk72	36	11	individual	individual	JJ
cord-012902-efprpk72	36	12	biomarkers	biomarker	NNS
cord-012902-efprpk72	36	13	of	of	IN
cord-012902-efprpk72	36	14	the	the	DT
cord-012902-efprpk72	36	15	association	association	NN
cord-012902-efprpk72	36	16	between	between	IN
cord-012902-efprpk72	36	17	fat	fat	NNP
cord-012902-efprpk72	36	18	mass	mass	NNP
cord-012902-efprpk72	36	19	and	and	CC
cord-012902-efprpk72	36	20	LVM	LVM	NNP
cord-012902-efprpk72	36	21	.	.	.
cord-012902-efprpk72	37	1	Height	height	NN
cord-012902-efprpk72	37	2	,	,	,
cord-012902-efprpk72	37	3	physical	physical	JJ
cord-012902-efprpk72	37	4	activity	activity	NN
cord-012902-efprpk72	37	5	,	,	,
cord-012902-efprpk72	37	6	smoking	smoking	NN
cord-012902-efprpk72	37	7	and	and	CC
cord-012902-efprpk72	37	8	socioeconomic	socioeconomic	JJ
cord-012902-efprpk72	37	9	position	position	NN
cord-012902-efprpk72	37	10	were	be	VBD
cord-012902-efprpk72	37	11	included	include	VBN
cord-012902-efprpk72	37	12	as	as	IN
cord-012902-efprpk72	37	13	confounders	confounder	NNS
cord-012902-efprpk72	37	14	.	.	.
cord-012902-efprpk72	38	1	Results	result	NNS
cord-012902-efprpk72	38	2	:	:	:
cord-012902-efprpk72	39	1	The	the	DT
cord-012902-efprpk72	39	2	roles	role	NNS
cord-012902-efprpk72	39	3	of	of	IN
cord-012902-efprpk72	39	4	mean	mean	JJ
cord-012902-efprpk72	39	5	arterial	arterial	JJ
cord-012902-efprpk72	39	6	pressure	pressure	NN
cord-012902-efprpk72	39	7	(	(	-LRB-
cord-012902-efprpk72	39	8	MAP	MAP	NNP
cord-012902-efprpk72	39	9	)	)	-RRB-
cord-012902-efprpk72	39	10	,	,	,
cord-012902-efprpk72	39	11	pulse	pulse	NN
cord-012902-efprpk72	39	12	pressure	pressure	NN
cord-012902-efprpk72	39	13	(	(	-LRB-
cord-012902-efprpk72	39	14	PP	PP	NNP
cord-012902-efprpk72	39	15	)	)	-RRB-
cord-012902-efprpk72	39	16	,	,	,
cord-012902-efprpk72	39	17	heart	heart	NN
cord-012902-efprpk72	39	18	rate	rate	NN
cord-012902-efprpk72	39	19	(	(	-LRB-
cord-012902-efprpk72	39	20	HR	HR	NNP
cord-012902-efprpk72	39	21	)	)	-RRB-
cord-012902-efprpk72	39	22	,	,	,
cord-012902-efprpk72	39	23	C	c	NN
cord-012902-efprpk72	39	24	-	-	HYPH
cord-012902-efprpk72	39	25	reactive	reactive	JJ
cord-012902-efprpk72	39	26	protein	protein	NN
cord-012902-efprpk72	39	27	(	(	-LRB-
cord-012902-efprpk72	39	28	CRP	CRP	NNP
cord-012902-efprpk72	39	29	)	)	-RRB-
cord-012902-efprpk72	39	30	,	,	,
cord-012902-efprpk72	39	31	acetylated	acetylated	JJ
cord-012902-efprpk72	39	32	glycoproteins	glycoprotein	NNS
cord-012902-efprpk72	39	33	(	(	-LRB-
cord-012902-efprpk72	39	34	GP	GP	NNP
cord-012902-efprpk72	39	35	)	)	-RRB-
cord-012902-efprpk72	39	36	and	and	CC
cord-012902-efprpk72	39	37	lean	lean	JJ
cord-012902-efprpk72	39	38	mass	mass	NN
cord-012902-efprpk72	39	39	as	as	IN
cord-012902-efprpk72	39	40	mediators	mediator	NNS
cord-012902-efprpk72	39	41	were	be	VBD
cord-012902-efprpk72	39	42	investigated	investigate	VBN
cord-012902-efprpk72	39	43	.	.	.
cord-012902-efprpk72	40	1	%	%	NN
cord-012902-efprpk72	40	2	Mediation	Mediation	NNP
cord-012902-efprpk72	40	3	by	by	IN
cord-012902-efprpk72	40	4	each	each	DT
cord-012902-efprpk72	40	5	biomarker	biomarker	NN
cord-012902-efprpk72	40	6	is	be	VBZ
cord-012902-efprpk72	40	7	shown	show	VBN
cord-012902-efprpk72	40	8	below	below	IN
cord-012902-efprpk72	40	9	(	(	-LRB-
cord-012902-efprpk72	40	10	%	%	NN
cord-012902-efprpk72	40	11	mediation	mediation	NN
cord-012902-efprpk72	40	12	=	=	NFP
cord-012902-efprpk72	41	1	total	total	JJ
cord-012902-efprpk72	41	2	effect	effect	NN
cord-012902-efprpk72	41	3	−	−	CD
cord-012902-efprpk72	41	4	indirect	indirect	JJ
cord-012902-efprpk72	41	5	(	(	-LRB-
cord-012902-efprpk72	41	6	mediated	mediate	VBN
cord-012902-efprpk72	41	7	)	)	-RRB-
cord-012902-efprpk72	41	8	effect	effect	NN
cord-012902-efprpk72	41	9	×	×	NNP
cord-012902-efprpk72	41	10	100	100	CD
cord-012902-efprpk72	41	11	)	)	-RRB-
cord-012902-efprpk72	42	1	(	(	-LRB-
cord-012902-efprpk72	42	2	p	p	NN
cord-012902-efprpk72	42	3	<	<	XX
cord-012902-efprpk72	42	4	0.001	0.001	CD
cord-012902-efprpk72	42	5	for	for	IN
cord-012902-efprpk72	42	6	all	all	DT
cord-012902-efprpk72	42	7	total	total	JJ
cord-012902-efprpk72	42	8	effects	effect	NNS
cord-012902-efprpk72	42	9	)	)	-RRB-
cord-012902-efprpk72	42	10	,	,	,
cord-012902-efprpk72	42	11	stratified	stratify	VBN
cord-012902-efprpk72	42	12	by	by	IN
cord-012902-efprpk72	42	13	sex	sex	NN
cord-012902-efprpk72	42	14	.	.	.
cord-012902-efprpk72	43	1	Lean	Lean	NNP
cord-012902-efprpk72	43	2	mass	mass	NN
cord-012902-efprpk72	43	3	has	have	VBZ
cord-012902-efprpk72	43	4	the	the	DT
cord-012902-efprpk72	43	5	largest	large	JJS
cord-012902-efprpk72	43	6	mediating	mediating	JJ
cord-012902-efprpk72	43	7	effect	effect	NN
cord-012902-efprpk72	43	8	and	and	CC
cord-012902-efprpk72	43	9	accounts	account	VBZ
cord-012902-efprpk72	43	10	for	for	IN
cord-012902-efprpk72	43	11	more	more	JJR
cord-012902-efprpk72	43	12	of	of	IN
cord-012902-efprpk72	43	13	the	the	DT
cord-012902-efprpk72	43	14	effect	effect	NN
cord-012902-efprpk72	43	15	of	of	IN
cord-012902-efprpk72	43	16	fat	fat	JJ
cord-012902-efprpk72	43	17	mass	mass	NN
cord-012902-efprpk72	43	18	on	on	IN
cord-012902-efprpk72	43	19	LVM	LVM	NNP
cord-012902-efprpk72	43	20	at	at	IN
cord-012902-efprpk72	43	21	age	age	NN
cord-012902-efprpk72	43	22	24	24	CD
cord-012902-efprpk72	43	23	than	than	IN
cord-012902-efprpk72	43	24	17	17	CD
cord-012902-efprpk72	43	25	.	.	.
cord-012902-efprpk72	44	1	MAP	MAP	NNP
cord-012902-efprpk72	44	2	and	and	CC
cord-012902-efprpk72	44	3	CRP	CRP	NNP
cord-012902-efprpk72	44	4	account	account	NN
cord-012902-efprpk72	44	5	for	for	IN
cord-012902-efprpk72	44	6	a	a	DT
cord-012902-efprpk72	44	7	small	small	JJ
cord-012902-efprpk72	44	8	part	part	NN
cord-012902-efprpk72	44	9	of	of	IN
cord-012902-efprpk72	44	10	the	the	DT
cord-012902-efprpk72	44	11	association	association	NN
cord-012902-efprpk72	44	12	,	,	,
cord-012902-efprpk72	44	13	while	while	IN
cord-012902-efprpk72	44	14	HR	HR	NNP
cord-012902-efprpk72	44	15	attenuates	attenuate	VBZ
cord-012902-efprpk72	44	16	the	the	DT
cord-012902-efprpk72	44	17	total	total	JJ
cord-012902-efprpk72	44	18	effect	effect	NN
cord-012902-efprpk72	44	19	.	.	.
cord-012902-efprpk72	45	1	Mediation	mediation	NN
cord-012902-efprpk72	45	2	by	by	IN
cord-012902-efprpk72	45	3	GP	GP	NNP
cord-012902-efprpk72	45	4	is	be	VBZ
cord-012902-efprpk72	45	5	only	only	RB
cord-012902-efprpk72	45	6	marginal	marginal	JJ
cord-012902-efprpk72	45	7	.	.	.
cord-012902-efprpk72	46	1	Collectively	collectively	RB
cord-012902-efprpk72	46	2	,	,	,
cord-012902-efprpk72	46	3	MAP	MAP	NNP
cord-012902-efprpk72	46	4	,	,	,
cord-012902-efprpk72	46	5	CRP	CRP	NNP
cord-012902-efprpk72	46	6	and	and	CC
cord-012902-efprpk72	46	7	GP	GP	NNP
cord-012902-efprpk72	46	8	mediate	mediate	VBP
cord-012902-efprpk72	46	9	only	only	RB
cord-012902-efprpk72	46	10	a	a	DT
cord-012902-efprpk72	46	11	small	small	JJ
cord-012902-efprpk72	46	12	amount	amount	NN
cord-012902-efprpk72	46	13	at	at	IN
cord-012902-efprpk72	46	14	ages	age	NNS
cord-012902-efprpk72	46	15	17	17	CD
cord-012902-efprpk72	46	16	and	and	CC
cord-012902-efprpk72	46	17	24	24	CD
cord-012902-efprpk72	46	18	.	.	.
cord-012902-efprpk72	47	1	Conclusions	conclusion	NNS
cord-012902-efprpk72	47	2	:	:	:
cord-012902-efprpk72	48	1	Although	although	IN
cord-012902-efprpk72	48	2	the	the	DT
cord-012902-efprpk72	48	3	extent	extent	NN
cord-012902-efprpk72	48	4	of	of	IN
cord-012902-efprpk72	48	5	mediation	mediation	NN
cord-012902-efprpk72	48	6	is	be	VBZ
cord-012902-efprpk72	48	7	usually	usually	RB
cord-012902-efprpk72	48	8	greater	great	JJR
cord-012902-efprpk72	48	9	in	in	IN
cord-012902-efprpk72	48	10	adulthood	adulthood	NN
cord-012902-efprpk72	48	11	compared	compare	VBN
cord-012902-efprpk72	48	12	with	with	IN
cord-012902-efprpk72	48	13	adolescence	adolescence	NN
cord-012902-efprpk72	48	14	,	,	,
cord-012902-efprpk72	48	15	the	the	DT
cord-012902-efprpk72	48	16	majority	majority	NN
cord-012902-efprpk72	48	17	of	of	IN
cord-012902-efprpk72	48	18	the	the	DT
cord-012902-efprpk72	48	19	association	association	NN
cord-012902-efprpk72	48	20	between	between	IN
cord-012902-efprpk72	48	21	fat	fat	NNP
cord-012902-efprpk72	48	22	mass	mass	NNP
cord-012902-efprpk72	48	23	and	and	CC
cord-012902-efprpk72	48	24	LVM	LVM	NNP
cord-012902-efprpk72	48	25	appears	appear	VBZ
cord-012902-efprpk72	48	26	to	to	TO
cord-012902-efprpk72	48	27	be	be	VB
cord-012902-efprpk72	48	28	a	a	DT
cord-012902-efprpk72	48	29	direct	direct	JJ
cord-012902-efprpk72	48	30	effect	effect	NN
cord-012902-efprpk72	48	31	at	at	IN
cord-012902-efprpk72	48	32	both	both	DT
cord-012902-efprpk72	48	33	ages	age	NNS
cord-012902-efprpk72	48	34	.	.	.
cord-012902-efprpk72	49	1	These	these	DT
cord-012902-efprpk72	49	2	results	result	NNS
cord-012902-efprpk72	49	3	serve	serve	VBP
cord-012902-efprpk72	49	4	as	as	IN
cord-012902-efprpk72	49	5	a	a	DT
cord-012902-efprpk72	49	6	reminder	reminder	NN
cord-012902-efprpk72	49	7	that	that	IN
cord-012902-efprpk72	49	8	adiposity	adiposity	NN
cord-012902-efprpk72	49	9	should	should	MD
cord-012902-efprpk72	49	10	be	be	VB
cord-012902-efprpk72	49	11	monitored	monitor	VBN
cord-012902-efprpk72	49	12	even	even	RB
cord-012902-efprpk72	49	13	from	from	IN
cord-012902-efprpk72	49	14	early	early	JJ
cord-012902-efprpk72	49	15	adulthood	adulthood	NN
cord-012902-efprpk72	49	16	.	.	.
cord-012902-efprpk72	50	1	Disclosures	disclosure	NNS
cord-012902-efprpk72	50	2	:	:	:
cord-012902-efprpk72	50	3	None	none	NN
cord-012902-efprpk72	50	4	.	.	.
cord-012902-efprpk72	51	1	Jun	Jun	NNP
cord-012902-efprpk72	51	2	Yu	Yu	NNP
cord-012902-efprpk72	51	3	Chen	Chen	NNP
cord-012902-efprpk72	51	4	1	1	CD
cord-012902-efprpk72	52	1	*	*	NFP
cord-012902-efprpk72	52	2	,	,	,
cord-012902-efprpk72	52	3	Sheon	Sheon	NNP
cord-012902-efprpk72	52	4	Mary	Mary	NNP
cord-012902-efprpk72	52	5	1	1	CD
cord-012902-efprpk72	52	6	,	,	,
cord-012902-efprpk72	52	7	Khai	Khai	NNP
cord-012902-efprpk72	52	8	Syuen	Syuen	NNP
cord-012902-efprpk72	53	1	Chew	Chew	NNP
cord-012902-efprpk72	53	2	1	1	CD
cord-012902-efprpk72	53	3	,	,	,
cord-012902-efprpk72	54	1	Professor	Professor	NNP
cord-012902-efprpk72	54	2	Rhian	Rhian	NNP
cord-012902-efprpk72	54	3	Touyz	Touyz	NNP
cord-012902-efprpk72	54	4	1	1	CD
cord-012902-efprpk72	54	5	,	,	,
cord-012902-efprpk72	54	6	Christian	Christian	NNP
cord-012902-efprpk72	54	7	Delles	Delles	NNP
cord-012902-efprpk72	54	8	1	1	CD
cord-012902-efprpk72	54	9	,	,	,
cord-012902-efprpk72	54	10	Giacomo	Giacomo	NNP
cord-012902-efprpk72	54	11	Rossitto	Rossitto	NNP
cord-012902-efprpk72	54	12	1	1	CD
cord-012902-efprpk72	54	13	1	1	CD
cord-012902-efprpk72	54	14	University	University	NNP
cord-012902-efprpk72	54	15	of	of	IN
cord-012902-efprpk72	54	16	Glasgow	Glasgow	NNP
cord-012902-efprpk72	54	17	,	,	,
cord-012902-efprpk72	54	18	Glasgow	Glasgow	NNP
cord-012902-efprpk72	54	19	,	,	,
cord-012902-efprpk72	55	1	UK	UK	NNP
cord-012902-efprpk72	55	2	Introduction	introduction	NN
cord-012902-efprpk72	55	3	:	:	:
cord-012902-efprpk72	55	4	While	while	IN
cord-012902-efprpk72	55	5	increasing	increase	VBG
cord-012902-efprpk72	55	6	evidence	evidence	NN
cord-012902-efprpk72	55	7	suggests	suggest	VBZ
cord-012902-efprpk72	55	8	excess	excess	JJ
cord-012902-efprpk72	55	9	skin	skin	NN
cord-012902-efprpk72	55	10	Na	Na	NNP
cord-012902-efprpk72	55	11	+	+	CC
cord-012902-efprpk72	55	12	accumulation	accumulation	NN
cord-012902-efprpk72	55	13	in	in	IN
cord-012902-efprpk72	55	14	hypertension	hypertension	NN
cord-012902-efprpk72	55	15	,	,	,
cord-012902-efprpk72	55	16	skin	skin	NN
cord-012902-efprpk72	55	17	-	-	HYPH
cord-012902-efprpk72	55	18	specific	specific	JJ
cord-012902-efprpk72	55	19	mechanisms	mechanism	NNS
cord-012902-efprpk72	55	20	of	of	IN
cord-012902-efprpk72	55	21	local	local	JJ
cord-012902-efprpk72	55	22	Na	Na	NNP
cord-012902-efprpk72	56	1	+	+	CC
cord-012902-efprpk72	56	2	/water	/water	.
cord-012902-efprpk72	56	3	regulation	regulation	NN
cord-012902-efprpk72	56	4	have	have	VBP
cord-012902-efprpk72	56	5	been	be	VBN
cord-012902-efprpk72	56	6	largely	largely	RB
cord-012902-efprpk72	56	7	ignored	ignore	VBN
cord-012902-efprpk72	56	8	.	.	.
cord-012902-efprpk72	57	1	We	-PRON-	PRP
cord-012902-efprpk72	57	2	investigated	investigate	VBD
cord-012902-efprpk72	57	3	the	the	DT
cord-012902-efprpk72	57	4	association	association	NN
cord-012902-efprpk72	57	5	between	between	IN
cord-012902-efprpk72	57	6	measures	measure	NNS
cord-012902-efprpk72	57	7	of	of	IN
cord-012902-efprpk72	57	8	sweat	sweat	NN
cord-012902-efprpk72	57	9	and	and	CC
cord-012902-efprpk72	57	10	transepidermal	transepidermal	JJ
cord-012902-efprpk72	57	11	water	water	NN
cord-012902-efprpk72	57	12	loss	loss	NN
cord-012902-efprpk72	57	13	(	(	-LRB-
cord-012902-efprpk72	57	14	TEWL	TEWL	NNP
cord-012902-efprpk72	57	15	)	)	-RRB-
cord-012902-efprpk72	57	16	,	,	,
cord-012902-efprpk72	57	17	skin	skin	NN
cord-012902-efprpk72	57	18	Na	Na	NNP
cord-012902-efprpk72	57	19	+	+	CC
cord-012902-efprpk72	57	20	content	content	NN
cord-012902-efprpk72	57	21	(	(	-LRB-
cord-012902-efprpk72	57	22	as	as	IN
cord-012902-efprpk72	57	23	a	a	DT
cord-012902-efprpk72	57	24	surrogate	surrogate	NN
cord-012902-efprpk72	57	25	of	of	IN
cord-012902-efprpk72	57	26	total	total	JJ
cord-012902-efprpk72	57	27	body	body	NN
cord-012902-efprpk72	58	1	Na	Na	NNP
cord-012902-efprpk72	58	2	+	+	CC
cord-012902-efprpk72	58	3	)	)	-RRB-
cord-012902-efprpk72	58	4	and	and	CC
cord-012902-efprpk72	58	5	clinical	clinical	JJ
cord-012902-efprpk72	58	6	parameters	parameter	NNS
cord-012902-efprpk72	58	7	in	in	IN
cord-012902-efprpk72	58	8	hypertensive	hypertensive	JJ
cord-012902-efprpk72	58	9	patients	patient	NNS
cord-012902-efprpk72	58	10	.	.	.
cord-012902-efprpk72	59	1	Methods	method	NNS
cord-012902-efprpk72	59	2	:	:	:
cord-012902-efprpk72	60	1	An	an	DT
cord-012902-efprpk72	60	2	iontophoretic	iontophoretic	JJ
cord-012902-efprpk72	60	3	pilocarpine	pilocarpine	NN
cord-012902-efprpk72	60	4	-	-	HYPH
cord-012902-efprpk72	60	5	induced	induce	VBN
cord-012902-efprpk72	60	6	sweat	sweat	NN
cord-012902-efprpk72	60	7	sample	sample	NN
cord-012902-efprpk72	60	8	,	,	,
cord-012902-efprpk72	60	9	measures	measure	NNS
cord-012902-efprpk72	60	10	of	of	IN
cord-012902-efprpk72	60	11	TEWL	TEWL	NNP
cord-012902-efprpk72	61	1	(	(	-LRB-
cord-012902-efprpk72	61	2	Tewameter	Tewameter	NNP
cord-012902-efprpk72	61	3	®	®	VB
cord-012902-efprpk72	61	4	,	,	.
cord-012902-efprpk72	62	1	COURAGE	COURAGE	NNP
cord-012902-efprpk72	62	2	+	+	CC
cord-012902-efprpk72	62	3	KHAZAKA	KHAZAKA	NNP
cord-012902-efprpk72	62	4	electronic	electronic	JJ
cord-012902-efprpk72	62	5	GmbH	GmbH	NNP
cord-012902-efprpk72	62	6	,	,	,
cord-012902-efprpk72	62	7	Köln	Köln	NNP
cord-012902-efprpk72	62	8	,	,	,
cord-012902-efprpk72	62	9	Germany	Germany	NNP
cord-012902-efprpk72	62	10	)	)	-RRB-
cord-012902-efprpk72	62	11	and	and	CC
cord-012902-efprpk72	62	12	a	a	DT
cord-012902-efprpk72	62	13	skin	skin	NN
cord-012902-efprpk72	62	14	punch	punch	NN
cord-012902-efprpk72	62	15	biopsy	biopsy	NN
cord-012902-efprpk72	62	16	were	be	VBD
cord-012902-efprpk72	62	17	collected	collect	VBN
cord-012902-efprpk72	62	18	from	from	IN
cord-012902-efprpk72	62	19	adult	adult	NN
cord-012902-efprpk72	62	20	,	,	,
cord-012902-efprpk72	62	21	non	non	JJ
cord-012902-efprpk72	62	22	-	-	JJ
cord-012902-efprpk72	62	23	pregnant	pregnant	JJ
cord-012902-efprpk72	62	24	hypertensive	hypertensive	JJ
cord-012902-efprpk72	62	25	patients	patient	NNS
cord-012902-efprpk72	62	26	at	at	IN
cord-012902-efprpk72	62	27	the	the	DT
cord-012902-efprpk72	62	28	Glasgow	Glasgow	NNP
cord-012902-efprpk72	62	29	Blood	Blood	NNP
cord-012902-efprpk72	62	30	Pressure	Pressure	NNP
cord-012902-efprpk72	62	31	Clinic	Clinic	NNP
cord-012902-efprpk72	62	32	(	(	-LRB-
cord-012902-efprpk72	62	33	n	n	NN
cord-012902-efprpk72	62	34	=	=	SYM
cord-012902-efprpk72	62	35	90	90	CD
cord-012902-efprpk72	62	36	;	;	:
cord-012902-efprpk72	62	37	age	age	NN
cord-012902-efprpk72	62	38	:	:	:
cord-012902-efprpk72	62	39	56	56	CD
cord-012902-efprpk72	62	40	±	±	CD
cord-012902-efprpk72	62	41	16	16	CD
cord-012902-efprpk72	62	42	,	,	,
cord-012902-efprpk72	62	43	range	range	VBP
cord-012902-efprpk72	62	44	21	21	CD
cord-012902-efprpk72	62	45	-	-	SYM
cord-012902-efprpk72	62	46	86	86	CD
cord-012902-efprpk72	62	47	years	year	NNS
cord-012902-efprpk72	62	48	;	;	:
cord-012902-efprpk72	62	49	females	female	NNS
cord-012902-efprpk72	62	50	=	=	SYM
cord-012902-efprpk72	62	51	48.9	48.9	CD
cord-012902-efprpk72	62	52	%	%	NN
cord-012902-efprpk72	62	53	;	;	:
cord-012902-efprpk72	62	54	BMI	bmi	NN
cord-012902-efprpk72	62	55	:	:	:
cord-012902-efprpk72	62	56	median	median	NN
cord-012902-efprpk72	62	57	=	=	SYM
cord-012902-efprpk72	62	58	29.8	29.8	CD
cord-012902-efprpk72	62	59	,	,	,
cord-012902-efprpk72	62	60	interquartile	interquartile	JJ
cord-012902-efprpk72	62	61	range	range	VBP
cord-012902-efprpk72	62	62	26.9	26.9	CD
cord-012902-efprpk72	62	63	-	-	HYPH
cord-012902-efprpk72	62	64	35.2	35.2	CD
cord-012902-efprpk72	62	65	kg	kg	NNS
cord-012902-efprpk72	62	66	/	/	SYM
cord-012902-efprpk72	62	67	m²	m²	NNP
cord-012902-efprpk72	62	68	)	)	-RRB-
cord-012902-efprpk72	62	69	.	.	.
cord-012902-efprpk72	63	1	Sweat	sweat	NN
cord-012902-efprpk72	63	2	and	and	CC
cord-012902-efprpk72	63	3	skin	skin	NN
cord-012902-efprpk72	63	4	Na	Na	NNP
cord-012902-efprpk72	64	1	+	+	UH
cord-012902-efprpk72	64	2	and	and	CC
cord-012902-efprpk72	64	3	K	K	NNP
cord-012902-efprpk72	64	4	+	+	CC
cord-012902-efprpk72	64	5	content	content	NN
cord-012902-efprpk72	64	6	was	be	VBD
cord-012902-efprpk72	64	7	assessed	assess	VBN
cord-012902-efprpk72	64	8	by	by	IN
cord-012902-efprpk72	64	9	flame	flame	NN
cord-012902-efprpk72	64	10	photometry	photometry	NN
cord-012902-efprpk72	64	11	.	.	.
cord-012902-efprpk72	65	1	Vascular	vascular	JJ
cord-012902-efprpk72	65	2	Endothelial	Endothelial	NNP
cord-012902-efprpk72	65	3	Growth	Growth	NNP
cord-012902-efprpk72	65	4	Factor	factor	NN
cord-012902-efprpk72	65	5	-	-	HYPH
cord-012902-efprpk72	65	6	c	c	NNP
cord-012902-efprpk72	65	7	(	(	-LRB-
cord-012902-efprpk72	65	8	VEGFc	VEGFc	NNP
cord-012902-efprpk72	65	9	)	)	-RRB-
cord-012902-efprpk72	65	10	was	be	VBD
cord-012902-efprpk72	65	11	measured	measure	VBN
cord-012902-efprpk72	65	12	in	in	IN
cord-012902-efprpk72	65	13	serum	serum	NN
cord-012902-efprpk72	65	14	(	(	-LRB-
cord-012902-efprpk72	65	15	Quantikine	Quantikine	NNP
cord-012902-efprpk72	65	16	ELISA	ELISA	NNP
cord-012902-efprpk72	65	17	,	,	,
cord-012902-efprpk72	65	18	R&D	r&d	NN
cord-012902-efprpk72	65	19	)	)	-RRB-
cord-012902-efprpk72	65	20	.	.	.
cord-012902-efprpk72	66	1	Results	result	NNS
cord-012902-efprpk72	66	2	:	:	:
cord-012902-efprpk72	67	1	In	in	IN
cord-012902-efprpk72	67	2	the	the	DT
cord-012902-efprpk72	67	3	whole	whole	JJ
cord-012902-efprpk72	67	4	cohort	cohort	NN
cord-012902-efprpk72	67	5	,	,	,
cord-012902-efprpk72	67	6	sweat	sweat	NN
cord-012902-efprpk72	67	7	Na	Na	NNP
cord-012902-efprpk72	67	8	+	+	CC
cord-012902-efprpk72	67	9	concentration	concentration	NN
cord-012902-efprpk72	68	1	(	(	-LRB-
cord-012902-efprpk72	68	2	[	[	-LRB-
cord-012902-efprpk72	68	3	Na	Na	NNP
cord-012902-efprpk72	68	4	+	+	CC
cord-012902-efprpk72	68	5	]	]	-RRB-
cord-012902-efprpk72	68	6	SWEAT	sweat	NN
cord-012902-efprpk72	68	7	;	;	:
cord-012902-efprpk72	68	8	]	]	-RRB-
cord-012902-efprpk72	68	9	mmol	mmol	NN
cord-012902-efprpk72	68	10	/	/	SYM
cord-012902-efprpk72	68	11	l	l	NN
cord-012902-efprpk72	68	12	)	)	-RRB-
cord-012902-efprpk72	68	13	was	be	VBD
cord-012902-efprpk72	68	14	inversely	inversely	RB
cord-012902-efprpk72	68	15	correlated	correlate	VBN
cord-012902-efprpk72	68	16	with	with	IN
cord-012902-efprpk72	68	17	[	[	-LRB-
cord-012902-efprpk72	68	18	K	k	NN
cord-012902-efprpk72	68	19	+	+	CC
cord-012902-efprpk72	68	20	]	]	-RRB-
cord-012902-efprpk72	68	21	SWEAT	sweat	NN
cord-012902-efprpk72	68	22	.	.	.
cord-012902-efprpk72	69	1	Patients	patient	NNS
cord-012902-efprpk72	69	2	who	who	WP
cord-012902-efprpk72	69	3	took	take	VBD
cord-012902-efprpk72	69	4	ACEIs	acei	NNS
cord-012902-efprpk72	69	5	/	/	SYM
cord-012902-efprpk72	69	6	ARBs	arb	NNS
cord-012902-efprpk72	69	7	had	have	VBD
cord-012902-efprpk72	69	8	higher	high	JJR
cord-012902-efprpk72	69	9	[	[	-LRB-
cord-012902-efprpk72	69	10	Na	Na	NNP
cord-012902-efprpk72	69	11	+	+	CC
cord-012902-efprpk72	69	12	]	]	-RRB-
cord-012902-efprpk72	69	13	SWEAT	sweat	NN
cord-012902-efprpk72	69	14	compared	compare	VBN
cord-012902-efprpk72	69	15	to	to	IN
cord-012902-efprpk72	69	16	those	those	DT
cord-012902-efprpk72	69	17	who	who	WP
cord-012902-efprpk72	69	18	did	do	VBD
cord-012902-efprpk72	69	19	not	not	RB
cord-012902-efprpk72	69	20	(	(	-LRB-
cord-012902-efprpk72	69	21	33	33	CD
cord-012902-efprpk72	69	22	[	[	-LRB-
cord-012902-efprpk72	69	23	26	26	CD
cord-012902-efprpk72	69	24	-	-	SYM
cord-012902-efprpk72	69	25	46	46	CD
cord-012902-efprpk72	69	26	]	]	-RRB-
cord-012902-efprpk72	69	27	vs	vs	IN
cord-012902-efprpk72	69	28	26	26	CD
cord-012902-efprpk72	69	29	[	[	-LRB-
cord-012902-efprpk72	69	30	18	18	CD
cord-012902-efprpk72	69	31	-	-	SYM
cord-012902-efprpk72	69	32	40	40	CD
cord-012902-efprpk72	69	33	]	]	-RRB-
cord-012902-efprpk72	69	34	mmol	mmol	NNP
cord-012902-efprpk72	69	35	/	/	SYM
cord-012902-efprpk72	69	36	l	l	NN
cord-012902-efprpk72	69	37	,	,	,
cord-012902-efprpk72	69	38	p	p	NN
cord-012902-efprpk72	69	39	<	<	XX
cord-012902-efprpk72	69	40	0.05	0.05	CD
cord-012902-efprpk72	69	41	)	)	-RRB-
cord-012902-efprpk72	69	42	,	,	,
cord-012902-efprpk72	69	43	whereas	whereas	IN
cord-012902-efprpk72	69	44	sweat	sweat	NN
cord-012902-efprpk72	69	45	composition	composition	NN
cord-012902-efprpk72	69	46	was	be	VBD
cord-012902-efprpk72	69	47	independent	independent	JJ
cord-012902-efprpk72	69	48	of	of	IN
cord-012902-efprpk72	69	49	sex	sex	NN
cord-012902-efprpk72	69	50	and	and	CC
cord-012902-efprpk72	69	51	BMI	BMI	NNP
cord-012902-efprpk72	69	52	.	.	.
cord-012902-efprpk72	70	1	We	-PRON-	PRP
cord-012902-efprpk72	70	2	observed	observe	VBD
cord-012902-efprpk72	70	3	a	a	DT
cord-012902-efprpk72	70	4	positive	positive	JJ
cord-012902-efprpk72	70	5	association	association	NN
cord-012902-efprpk72	70	6	between	between	IN
cord-012902-efprpk72	70	7	[	[	-LRB-
cord-012902-efprpk72	70	8	Na	Na	NNP
cord-012902-efprpk72	70	9	+	+	CC
cord-012902-efprpk72	70	10	]	]	-RRB-
cord-012902-efprpk72	71	1	in	in	IN
cord-012902-efprpk72	71	2	epidermis	epidermis	NN
cord-012902-efprpk72	71	3	/	/	SYM
cord-012902-efprpk72	71	4	superficial	superficial	JJ
cord-012902-efprpk72	71	5	dermis	dermis	NN
cord-012902-efprpk72	71	6	(	(	-LRB-
cord-012902-efprpk72	71	7	ESD	ESD	NNP
cord-012902-efprpk72	71	8	)	)	-RRB-
cord-012902-efprpk72	71	9	and	and	CC
cord-012902-efprpk72	71	10	[	[	-LRB-
cord-012902-efprpk72	71	11	Na	Na	NNP
cord-012902-efprpk72	71	12	+	+	CC
cord-012902-efprpk72	71	13	]	]	-RRB-
cord-012902-efprpk72	71	14	SWEAT	sweat	NN
cord-012902-efprpk72	71	15	,	,	,
cord-012902-efprpk72	71	16	independent	independent	JJ
cord-012902-efprpk72	71	17	of	of	IN
cord-012902-efprpk72	71	18	sex	sex	NN
cord-012902-efprpk72	71	19	,	,	,
cord-012902-efprpk72	71	20	BMI	BMI	NNP
cord-012902-efprpk72	71	21	and	and	CC
cord-012902-efprpk72	71	22	use	use	NN
cord-012902-efprpk72	71	23	of	of	IN
cord-012902-efprpk72	71	24	ACEi	ACEi	NNS
cord-012902-efprpk72	71	25	/	/	SYM
cord-012902-efprpk72	71	26	ARBs	arb	NNS
cord-012902-efprpk72	71	27	(	(	-LRB-
cord-012902-efprpk72	71	28	p	p	NN
cord-012902-efprpk72	71	29	adjusted	adjust	VBN
cord-012902-efprpk72	71	30	=	=	SYM
cord-012902-efprpk72	71	31	0.025	0.025	CD
cord-012902-efprpk72	71	32	)	)	-RRB-
cord-012902-efprpk72	71	33	;	;	:
cord-012902-efprpk72	71	34	both	both	CC
cord-012902-efprpk72	71	35	[	[	-LRB-
cord-012902-efprpk72	71	36	Na	Na	NNP
cord-012902-efprpk72	71	37	+	+	CC
cord-012902-efprpk72	71	38	]	]	-RRB-
cord-012902-efprpk72	71	39	ESD	ESD	NNP
cord-012902-efprpk72	71	40	and	and	CC
cord-012902-efprpk72	71	41	[	[	-LRB-
cord-012902-efprpk72	71	42	Na	Na	NNP
cord-012902-efprpk72	71	43	+	+	CC
cord-012902-efprpk72	71	44	]	]	-RRB-
cord-012902-efprpk72	71	45	SWEAT	sweat	NN
cord-012902-efprpk72	71	46	closely	closely	RB
cord-012902-efprpk72	71	47	correlated	correlate	VBD
cord-012902-efprpk72	71	48	with	with	IN
cord-012902-efprpk72	71	49	age	age	NN
cord-012902-efprpk72	71	50	(	(	-LRB-
cord-012902-efprpk72	71	51	p	p	NN
cord-012902-efprpk72	71	52	<	<	XX
cord-012902-efprpk72	71	53	0.01	0.01	CD
cord-012902-efprpk72	71	54	)	)	-RRB-
cord-012902-efprpk72	71	55	.	.	.
cord-012902-efprpk72	72	1	Office	office	NN
cord-012902-efprpk72	72	2	DBP	dbp	NN
cord-012902-efprpk72	72	3	but	but	CC
cord-012902-efprpk72	72	4	not	not	RB
cord-012902-efprpk72	73	1	SBP	SBP	NNP
cord-012902-efprpk72	73	2	was	be	VBD
cord-012902-efprpk72	73	3	inversely	inversely	RB
cord-012902-efprpk72	73	4	correlated	correlate	VBN
cord-012902-efprpk72	73	5	with	with	IN
cord-012902-efprpk72	73	6	[	[	-LRB-
cord-012902-efprpk72	73	7	Na	Na	NNP
cord-012902-efprpk72	73	8	+	+	CC
cord-012902-efprpk72	73	9	]	]	-RRB-
cord-012902-efprpk72	73	10	SWEAT	sweat	NN
cord-012902-efprpk72	74	1	(	(	-LRB-
cord-012902-efprpk72	74	2	r	r	NN
cord-012902-efprpk72	74	3	=	=	SYM
cord-012902-efprpk72	74	4	−0.312	−0.312	NNP
cord-012902-efprpk72	74	5	,	,	,
cord-012902-efprpk72	74	6	p	p	NN
cord-012902-efprpk72	74	7	=	=	SYM
cord-012902-efprpk72	74	8	0.006	0.006	CD
cord-012902-efprpk72	74	9	)	)	-RRB-
cord-012902-efprpk72	74	10	,	,	,
cord-012902-efprpk72	74	11	independent	independent	JJ
cord-012902-efprpk72	74	12	of	of	IN
cord-012902-efprpk72	74	13	age	age	NN
cord-012902-efprpk72	74	14	and	and	CC
cord-012902-efprpk72	74	15	other	other	JJ
cord-012902-efprpk72	74	16	potential	potential	JJ
cord-012902-efprpk72	74	17	confounders	confounder	NNS
cord-012902-efprpk72	75	1	(	(	-LRB-
cord-012902-efprpk72	75	2	p	p	NN
cord-012902-efprpk72	75	3	adjusted	adjust	VBN
cord-012902-efprpk72	75	4	=	=	SYM
cord-012902-efprpk72	75	5	0.02	0.02	CD
cord-012902-efprpk72	75	6	)	)	-RRB-
cord-012902-efprpk72	75	7	.	.	.
cord-012902-efprpk72	76	1	Total	total	JJ
cord-012902-efprpk72	76	2	sweat	sweat	NN
cord-012902-efprpk72	76	3	volume	volume	NN
cord-012902-efprpk72	76	4	and	and	CC
cord-012902-efprpk72	76	5	excreted	excrete	VBD
cord-012902-efprpk72	76	6	Na	Na	NNP
cord-012902-efprpk72	77	1	+	+	UH
cord-012902-efprpk72	77	2	,	,	.
cord-012902-efprpk72	78	1	but	but	CC
cord-012902-efprpk72	78	2	not	not	RB
cord-012902-efprpk72	78	3	[	[	-LRB-
cord-012902-efprpk72	78	4	Na	Na	NNP
cord-012902-efprpk72	78	5	+	+	CC
cord-012902-efprpk72	78	6	]	]	-RRB-
cord-012902-efprpk72	78	7	SWEAT	sweat	NN
cord-012902-efprpk72	78	8	,	,	,
cord-012902-efprpk72	78	9	were	be	VBD
cord-012902-efprpk72	78	10	lower	low	JJR
cord-012902-efprpk72	78	11	in	in	IN
cord-012902-efprpk72	78	12	patients	patient	NNS
cord-012902-efprpk72	78	13	with	with	IN
cord-012902-efprpk72	78	14	uncontrolled	uncontrolled	JJ
cord-012902-efprpk72	78	15	office	office	NN
cord-012902-efprpk72	78	16	BP	BP	NNP
cord-012902-efprpk72	78	17	(	(	-LRB-
cord-012902-efprpk72	78	18	p	p	NN
cord-012902-efprpk72	78	19	<	<	XX
cord-012902-efprpk72	78	20	0.01	0.01	CD
cord-012902-efprpk72	78	21	for	for	IN
cord-012902-efprpk72	78	22	both	both	DT
cord-012902-efprpk72	78	23	;	;	:
cord-012902-efprpk72	78	24	p	p	NN
cord-012902-efprpk72	78	25	adjusted	adjust	VBN
cord-012902-efprpk72	78	26	<	<	XX
cord-012902-efprpk72	78	27	0.005	0.005	CD
cord-012902-efprpk72	78	28	)	)	-RRB-
cord-012902-efprpk72	78	29	;	;	:
cord-012902-efprpk72	78	30	additionally	additionally	RB
cord-012902-efprpk72	78	31	,	,	,
cord-012902-efprpk72	78	32	sweat	sweat	NN
cord-012902-efprpk72	78	33	volume	volume	NN
cord-012902-efprpk72	78	34	positively	positively	RB
cord-012902-efprpk72	78	35	correlated	correlate	VBN
cord-012902-efprpk72	78	36	with	with	IN
cord-012902-efprpk72	78	37	TEWL	TEWL	NNP
cord-012902-efprpk72	78	38	and	and	CC
cord-012902-efprpk72	78	39	serum	serum	NN
cord-012902-efprpk72	78	40	-	-	HYPH
cord-012902-efprpk72	78	41	VEGFc	VEGFc	NNS
cord-012902-efprpk72	79	1	(	(	-LRB-
cord-012902-efprpk72	79	2	p	p	NN
cord-012902-efprpk72	79	3	<	<	XX
cord-012902-efprpk72	79	4	0.05	0.05	CD
cord-012902-efprpk72	79	5	for	for	IN
cord-012902-efprpk72	79	6	both	both	DT
cord-012902-efprpk72	79	7	)	)	-RRB-
cord-012902-efprpk72	79	8	.	.	.
cord-012902-efprpk72	80	1	Conclusions	conclusion	NNS
cord-012902-efprpk72	80	2	:	:	:
cord-012902-efprpk72	81	1	Sweat	sweat	NN
cord-012902-efprpk72	81	2	and	and	CC
cord-012902-efprpk72	81	3	TEWL	TEWL	NNP
cord-012902-efprpk72	81	4	appear	appear	VBP
cord-012902-efprpk72	81	5	to	to	TO
cord-012902-efprpk72	81	6	participate	participate	VB
cord-012902-efprpk72	81	7	in	in	IN
cord-012902-efprpk72	81	8	the	the	DT
cord-012902-efprpk72	81	9	systemic	systemic	JJ
cord-012902-efprpk72	81	10	regulation	regulation	NN
cord-012902-efprpk72	81	11	of	of	IN
cord-012902-efprpk72	81	12	total	total	JJ
cord-012902-efprpk72	81	13	body	body	NN
cord-012902-efprpk72	81	14	Na	Na	NNP
cord-012902-efprpk72	81	15	+	+	CC
cord-012902-efprpk72	81	16	in	in	IN
cord-012902-efprpk72	81	17	hypertension	hypertension	NN
cord-012902-efprpk72	81	18	.	.	.
cord-012902-efprpk72	82	1	In	in	IN
cord-012902-efprpk72	82	2	light	light	NN
cord-012902-efprpk72	82	3	of	of	IN
cord-012902-efprpk72	82	4	potential	potential	JJ
cord-012902-efprpk72	82	5	therapeutic	therapeutic	JJ
cord-012902-efprpk72	82	6	implications	implication	NNS
cord-012902-efprpk72	82	7	,	,	,
cord-012902-efprpk72	82	8	the	the	DT
cord-012902-efprpk72	82	9	contribution	contribution	NN
cord-012902-efprpk72	82	10	of	of	IN
cord-012902-efprpk72	82	11	skin	skin	NN
cord-012902-efprpk72	82	12	-	-	HYPH
cord-012902-efprpk72	82	13	specific	specific	JJ
cord-012902-efprpk72	82	14	mechanisms	mechanism	NNS
cord-012902-efprpk72	82	15	to	to	IN
cord-012902-efprpk72	82	16	Na	Na	NNP
cord-012902-efprpk72	82	17	+	+	CC
cord-012902-efprpk72	82	18	homoeostasis	homoeostasis	NN
cord-012902-efprpk72	82	19	and	and	CC
cord-012902-efprpk72	82	20	their	-PRON-	PRP$
cord-012902-efprpk72	82	21	relationship	relationship	NN
cord-012902-efprpk72	82	22	with	with	IN
cord-012902-efprpk72	82	23	microvascular	microvascular	JJ
cord-012902-efprpk72	82	24	function	function	NN
cord-012902-efprpk72	82	25	deserve	deserve	VBP
cord-012902-efprpk72	82	26	further	further	JJ
cord-012902-efprpk72	82	27	research	research	NN
cord-012902-efprpk72	82	28	.	.	.
cord-012902-efprpk72	83	1	Disclosures	disclosure	NNS
cord-012902-efprpk72	83	2	:	:	:
cord-012902-efprpk72	83	3	None	none	NN
cord-012902-efprpk72	83	4	.	.	.
cord-012902-efprpk72	84	1	cardiovascular	cardiovascular	JJ
cord-012902-efprpk72	84	2	disease	disease	NN
cord-012902-efprpk72	84	3	.	.	.
cord-012902-efprpk72	85	1	We	-PRON-	PRP
cord-012902-efprpk72	85	2	recently	recently	RB
cord-012902-efprpk72	85	3	published	publish	VBD
cord-012902-efprpk72	85	4	initial	initial	JJ
cord-012902-efprpk72	85	5	evidence	evidence	NN
cord-012902-efprpk72	85	6	for	for	IN
cord-012902-efprpk72	85	7	associations	association	NNS
cord-012902-efprpk72	85	8	of	of	IN
cord-012902-efprpk72	85	9	IAD	IAD	NNP
cord-012902-efprpk72	85	10	with	with	IN
cord-012902-efprpk72	85	11	prospective	prospective	JJ
cord-012902-efprpk72	85	12	cognitive	cognitive	JJ
cord-012902-efprpk72	85	13	decline	decline	NN
cord-012902-efprpk72	85	14	and	and	CC
cord-012902-efprpk72	85	15	now	now	RB
cord-012902-efprpk72	85	16	present	present	JJ
cord-012902-efprpk72	85	17	findings	finding	NNS
cord-012902-efprpk72	85	18	from	from	IN
cord-012902-efprpk72	85	19	the	the	DT
cord-012902-efprpk72	85	20	INTERPRESS	INTERPRESS	NNP
cord-012902-efprpk72	85	21	-	-	HYPH
cord-012902-efprpk72	85	22	IPD	IPD	NNP
cord-012902-efprpk72	85	23	Collaboration	Collaboration	NNP
cord-012902-efprpk72	85	24	,	,	,
cord-012902-efprpk72	85	25	examining	examine	VBG
cord-012902-efprpk72	85	26	associations	association	NNS
cord-012902-efprpk72	85	27	of	of	IN
cord-012902-efprpk72	85	28	IAD	IAD	NNP
cord-012902-efprpk72	85	29	with	with	IN
cord-012902-efprpk72	85	30	development	development	NN
cord-012902-efprpk72	85	31	of	of	IN
cord-012902-efprpk72	85	32	mild	mild	JJ
cord-012902-efprpk72	85	33	cognitive	cognitive	JJ
cord-012902-efprpk72	85	34	impairment	impairment	NN
cord-012902-efprpk72	85	35	(	(	-LRB-
cord-012902-efprpk72	85	36	MCI	MCI	NNP
cord-012902-efprpk72	85	37	)	)	-RRB-
cord-012902-efprpk72	85	38	and	and	CC
cord-012902-efprpk72	85	39	dementia	dementia	NN
cord-012902-efprpk72	85	40	.	.	.
cord-012902-efprpk72	86	1	Methods	method	NNS
cord-012902-efprpk72	86	2	:	:	:
cord-012902-efprpk72	87	1	Individual	individual	JJ
cord-012902-efprpk72	87	2	participant	participant	NN
cord-012902-efprpk72	87	3	data	datum	NNS
cord-012902-efprpk72	87	4	meta	meta	NNP
cord-012902-efprpk72	87	5	-	-	HYPH
cord-012902-efprpk72	87	6	analyses	analysis	NNS
cord-012902-efprpk72	87	7	.	.	.
cord-012902-efprpk72	88	1	We	-PRON-	PRP
cord-012902-efprpk72	88	2	examined	examine	VBD
cord-012902-efprpk72	88	3	time	time	NN
cord-012902-efprpk72	88	4	-	-	HYPH
cord-012902-efprpk72	88	5	to	to	IN
cord-012902-efprpk72	88	6	-	-	HYPH
cord-012902-efprpk72	88	7	event	event	NN
cord-012902-efprpk72	88	8	data	datum	NNS
cord-012902-efprpk72	88	9	for	for	IN
cord-012902-efprpk72	88	10	new	new	JJ
cord-012902-efprpk72	88	11	diagnoses	diagnosis	NNS
cord-012902-efprpk72	88	12	of	of	IN
cord-012902-efprpk72	88	13	MCI	MCI	NNP
cord-012902-efprpk72	88	14	and	and	CC
cord-012902-efprpk72	88	15	dementia	dementia	NN
cord-012902-efprpk72	88	16	,	,	,
cord-012902-efprpk72	88	17	according	accord	VBG
cord-012902-efprpk72	88	18	to	to	IN
cord-012902-efprpk72	88	19	IAD	IAD	NNP
cord-012902-efprpk72	88	20	status	status	NN
cord-012902-efprpk72	88	21	in	in	IN
cord-012902-efprpk72	88	22	univariable	univariable	JJ
cord-012902-efprpk72	88	23	and	and	CC
cord-012902-efprpk72	88	24	multivariable	multivariable	JJ
cord-012902-efprpk72	88	25	regression	regression	NN
cord-012902-efprpk72	88	26	models	model	NNS
cord-012902-efprpk72	88	27	,	,	,
cord-012902-efprpk72	88	28	stratified	stratify	VBN
cord-012902-efprpk72	88	29	by	by	IN
cord-012902-efprpk72	88	30	study	study	NN
cord-012902-efprpk72	88	31	.	.	.
cord-012902-efprpk72	89	1	Multivariable	multivariable	JJ
cord-012902-efprpk72	89	2	analyses	analysis	NNS
cord-012902-efprpk72	89	3	were	be	VBD
cord-012902-efprpk72	89	4	adjusted	adjust	VBN
cord-012902-efprpk72	89	5	for	for	IN
cord-012902-efprpk72	89	6	systolic	systolic	JJ
cord-012902-efprpk72	89	7	BP	BP	NNP
cord-012902-efprpk72	89	8	,	,	,
cord-012902-efprpk72	89	9	age	age	NN
cord-012902-efprpk72	89	10	,	,	,
cord-012902-efprpk72	89	11	sex	sex	NN
cord-012902-efprpk72	89	12	and	and	CC
cord-012902-efprpk72	89	13	highest	high	JJS
cord-012902-efprpk72	89	14	educational	educational	JJ
cord-012902-efprpk72	89	15	attainment	attainment	NN
cord-012902-efprpk72	89	16	.	.	.
cord-012902-efprpk72	90	1	We	-PRON-	PRP
cord-012902-efprpk72	90	2	also	also	RB
cord-012902-efprpk72	90	3	examined	examine	VBD
cord-012902-efprpk72	90	4	changes	change	NNS
cord-012902-efprpk72	90	5	in	in	IN
cord-012902-efprpk72	90	6	Mental	Mental	NNP
cord-012902-efprpk72	90	7	State	State	NNP
cord-012902-efprpk72	90	8	Examination	Examination	NNP
cord-012902-efprpk72	90	9	(	(	-LRB-
cord-012902-efprpk72	90	10	MSE	MSE	NNP
cord-012902-efprpk72	90	11	)	)	-RRB-
cord-012902-efprpk72	90	12	scores	score	NNS
cord-012902-efprpk72	90	13	,	,	,
cord-012902-efprpk72	90	14	with	with	IN
cord-012902-efprpk72	90	15	adjustments	adjustment	NNS
cord-012902-efprpk72	90	16	as	as	IN
cord-012902-efprpk72	90	17	above	above	RB
cord-012902-efprpk72	90	18	,	,	,
cord-012902-efprpk72	90	19	plus	plus	CC
cord-012902-efprpk72	90	20	follow	follow	NN
cord-012902-efprpk72	90	21	-	-	HYPH
cord-012902-efprpk72	90	22	up	up	RP
cord-012902-efprpk72	90	23	duration	duration	NN
cord-012902-efprpk72	90	24	.	.	.
cord-012902-efprpk72	91	1	Results	result	NNS
cord-012902-efprpk72	91	2	:	:	:
cord-012902-efprpk72	92	1	Mean	mean	JJ
cord-012902-efprpk72	92	2	age	age	NN
cord-012902-efprpk72	92	3	was	be	VBD
cord-012902-efprpk72	92	4	66.2	66.2	CD
cord-012902-efprpk72	92	5	years	year	NNS
cord-012902-efprpk72	92	6	,	,	,
cord-012902-efprpk72	92	7	55	55	CD
cord-012902-efprpk72	92	8	%	%	NN
cord-012902-efprpk72	92	9	were	be	VBD
cord-012902-efprpk72	92	10	female	female	JJ
cord-012902-efprpk72	92	11	,	,	,
cord-012902-efprpk72	92	12	84	84	CD
cord-012902-efprpk72	92	13	%	%	NN
cord-012902-efprpk72	92	14	were	be	VBD
cord-012902-efprpk72	92	15	of	of	IN
cord-012902-efprpk72	92	16	White	white	JJ
cord-012902-efprpk72	92	17	ethnicity	ethnicity	NN
cord-012902-efprpk72	92	18	and	and	CC
cord-012902-efprpk72	92	19	mean	mean	VB
cord-012902-efprpk72	92	20	systolic	systolic	JJ
cord-012902-efprpk72	92	21	IAD	IAD	NNP
cord-012902-efprpk72	92	22	was	be	VBD
cord-012902-efprpk72	92	23	7.0	7.0	CD
cord-012902-efprpk72	92	24	mmHg	mmHg	NNS
cord-012902-efprpk72	92	25	.	.	.
cord-012902-efprpk72	93	1	During	during	IN
cord-012902-efprpk72	93	2	10-year	10-year	CD
cord-012902-efprpk72	93	3	follow	follow	NN
cord-012902-efprpk72	93	4	-	-	HYPH
cord-012902-efprpk72	93	5	up	up	NN
cord-012902-efprpk72	93	6	,	,	,
cord-012902-efprpk72	93	7	5.9	5.9	CD
cord-012902-efprpk72	93	8	%	%	NN
cord-012902-efprpk72	93	9	of	of	IN
cord-012902-efprpk72	93	10	4635	4635	CD
cord-012902-efprpk72	93	11	individuals	individual	NNS
cord-012902-efprpk72	93	12	,	,	,
cord-012902-efprpk72	93	13	from	from	IN
cord-012902-efprpk72	93	14	3	3	CD
cord-012902-efprpk72	93	15	cohorts	cohort	NNS
cord-012902-efprpk72	93	16	,	,	,
cord-012902-efprpk72	93	17	had	have	VBD
cord-012902-efprpk72	93	18	new	new	JJ
cord-012902-efprpk72	93	19	diagnoses	diagnosis	NNS
cord-012902-efprpk72	93	20	of	of	IN
cord-012902-efprpk72	93	21	MCI	MCI	NNP
cord-012902-efprpk72	93	22	.	.	.
cord-012902-efprpk72	94	1	In	in	IN
cord-012902-efprpk72	94	2	univariable	univariable	JJ
cord-012902-efprpk72	94	3	analyses	analysis	NNS
cord-012902-efprpk72	94	4	,	,	,
cord-012902-efprpk72	94	5	MCI	MCI	NNP
cord-012902-efprpk72	94	6	was	be	VBD
cord-012902-efprpk72	94	7	associated	associate	VBN
cord-012902-efprpk72	94	8	with	with	IN
cord-012902-efprpk72	94	9	systolic	systolic	JJ
cord-012902-efprpk72	94	10	IAD	IAD	NNP
cord-012902-efprpk72	94	11	≥	≥	CD
cord-012902-efprpk72	94	12	5	5	CD
cord-012902-efprpk72	94	13	mmHg	mmHg	NNP
cord-012902-efprpk72	94	14	[	[	-LRB-
cord-012902-efprpk72	94	15	Hazard	Hazard	NNP
cord-012902-efprpk72	94	16	Ratio	Ratio	NNP
cord-012902-efprpk72	94	17	,	,	,
cord-012902-efprpk72	94	18	1.34	1.34	CD
cord-012902-efprpk72	94	19	(	(	-LRB-
cord-012902-efprpk72	94	20	95	95	CD
cord-012902-efprpk72	94	21	%	%	NN
cord-012902-efprpk72	94	22	CI	CI	NNP
cord-012902-efprpk72	94	23	1.04	1.04	CD
cord-012902-efprpk72	94	24	-	-	SYM
cord-012902-efprpk72	94	25	1.72	1.72	CD
cord-012902-efprpk72	94	26	)	)	-RRB-
cord-012902-efprpk72	94	27	;	;	:
cord-012902-efprpk72	94	28	p	p	NN
cord-012902-efprpk72	94	29	=	=	SYM
cord-012902-efprpk72	94	30	0.022	0.022	CD
cord-012902-efprpk72	94	31	]	]	-RRB-
cord-012902-efprpk72	94	32	and	and	CC
cord-012902-efprpk72	94	33	≥10	≥10	NNP
cord-012902-efprpk72	94	34	mmHg	mmHg	NNPS
cord-012902-efprpk72	94	35	[	[	-LRB-
cord-012902-efprpk72	94	36	1.33	1.33	CD
cord-012902-efprpk72	94	37	(	(	-LRB-
cord-012902-efprpk72	94	38	1.03	1.03	CD
cord-012902-efprpk72	94	39	-	-	SYM
cord-012902-efprpk72	94	40	1.73	1.73	CD
cord-012902-efprpk72	94	41	)	)	-RRB-
cord-012902-efprpk72	94	42	;	;	:
cord-012902-efprpk72	94	43	p	p	NN
cord-012902-efprpk72	94	44	=	=	SYM
cord-012902-efprpk72	94	45	0.032	0.032	CD
cord-012902-efprpk72	94	46	]	]	-RRB-
cord-012902-efprpk72	94	47	.	.	.
cord-012902-efprpk72	95	1	After	after	IN
cord-012902-efprpk72	95	2	adjustment	adjustment	NN
cord-012902-efprpk72	95	3	,	,	,
cord-012902-efprpk72	95	4	associations	association	NNS
cord-012902-efprpk72	95	5	with	with	IN
cord-012902-efprpk72	95	6	systolic	systolic	JJ
cord-012902-efprpk72	95	7	IADs	iad	NNS
cord-012902-efprpk72	95	8	≥	≥	CD
cord-012902-efprpk72	95	9	5mmHg	5mmhg	CD
cord-012902-efprpk72	95	10	(	(	-LRB-
cord-012902-efprpk72	95	11	p	p	NN
cord-012902-efprpk72	95	12	=	=	SYM
cord-012902-efprpk72	95	13	0.036	0.036	CD
cord-012902-efprpk72	95	14	)	)	-RRB-
cord-012902-efprpk72	95	15	and	and	CC
cord-012902-efprpk72	95	16	≥10	≥10	NNP
cord-012902-efprpk72	95	17	mmHg	mmHg	NNS
cord-012902-efprpk72	95	18	(	(	-LRB-
cord-012902-efprpk72	95	19	p	p	NN
cord-012902-efprpk72	95	20	=	=	SYM
cord-012902-efprpk72	95	21	0.056	0.056	CD
cord-012902-efprpk72	95	22	)	)	-RRB-
cord-012902-efprpk72	95	23	remained	remain	VBD
cord-012902-efprpk72	95	24	.	.	.
cord-012902-efprpk72	96	1	There	there	EX
cord-012902-efprpk72	96	2	were	be	VBD
cord-012902-efprpk72	96	3	95	95	CD
cord-012902-efprpk72	96	4	new	new	JJ
cord-012902-efprpk72	96	5	diagnoses	diagnosis	NNS
cord-012902-efprpk72	96	6	of	of	IN
cord-012902-efprpk72	96	7	dementia	dementia	NN
cord-012902-efprpk72	96	8	during	during	IN
cord-012902-efprpk72	96	9	follow	follow	NN
cord-012902-efprpk72	96	10	-	-	HYPH
cord-012902-efprpk72	96	11	up	up	NN
cord-012902-efprpk72	96	12	;	;	:
cord-012902-efprpk72	96	13	no	no	DT
cord-012902-efprpk72	96	14	associations	association	NNS
cord-012902-efprpk72	96	15	were	be	VBD
cord-012902-efprpk72	96	16	observed	observe	VBN
cord-012902-efprpk72	96	17	between	between	IN
cord-012902-efprpk72	96	18	dementia	dementia	NN
cord-012902-efprpk72	96	19	diagnosis	diagnosis	NN
cord-012902-efprpk72	96	20	and	and	CC
cord-012902-efprpk72	96	21	IAD	IAD	NNP
cord-012902-efprpk72	96	22	.	.	.
cord-012902-efprpk72	97	1	MSE	MSE	NNP
cord-012902-efprpk72	97	2	scores	score	NNS
cord-012902-efprpk72	97	3	were	be	VBD
cord-012902-efprpk72	97	4	recorded	record	VBN
cord-012902-efprpk72	97	5	for	for	IN
cord-012902-efprpk72	97	6	2709	2709	CD
cord-012902-efprpk72	97	7	participants	participant	NNS
cord-012902-efprpk72	97	8	;	;	:
cord-012902-efprpk72	97	9	15.5	15.5	CD
cord-012902-efprpk72	97	10	%	%	NN
cord-012902-efprpk72	97	11	showed	show	VBD
cord-012902-efprpk72	97	12	clinically	clinically	RB
cord-012902-efprpk72	97	13	meaningful	meaningful	JJ
cord-012902-efprpk72	97	14	reductions	reduction	NNS
cord-012902-efprpk72	97	15	(	(	-LRB-
cord-012902-efprpk72	97	16	≥5	≥5	NN
cord-012902-efprpk72	97	17	points	point	NNS
cord-012902-efprpk72	97	18	)	)	-RRB-
cord-012902-efprpk72	97	19	during	during	IN
cord-012902-efprpk72	97	20	follow	follow	NN
cord-012902-efprpk72	97	21	-	-	HYPH
cord-012902-efprpk72	97	22	up	up	NN
cord-012902-efprpk72	97	23	.	.	.
cord-012902-efprpk72	98	1	Decreases	decrease	NNS
cord-012902-efprpk72	98	2	were	be	VBD
cord-012902-efprpk72	98	3	associated	associate	VBN
cord-012902-efprpk72	98	4	with	with	IN
cord-012902-efprpk72	98	5	IADs	iad	NNS
cord-012902-efprpk72	98	6	≥5	≥5	NNP
cord-012902-efprpk72	98	7	mmHg	mmHg	NNS
cord-012902-efprpk72	98	8	(	(	-LRB-
cord-012902-efprpk72	98	9	p	p	NN
cord-012902-efprpk72	98	10	=	=	SYM
cord-012902-efprpk72	98	11	0.004	0.004	CD
cord-012902-efprpk72	98	12	)	)	-RRB-
cord-012902-efprpk72	98	13	and	and	CC
cord-012902-efprpk72	98	14	≥10	≥10	NNP
cord-012902-efprpk72	98	15	mmHg	mmHg	NNS
cord-012902-efprpk72	98	16	(	(	-LRB-
cord-012902-efprpk72	98	17	p	p	NN
cord-012902-efprpk72	98	18	=	=	SYM
cord-012902-efprpk72	98	19	0.006	0.006	CD
cord-012902-efprpk72	98	20	)	)	-RRB-
cord-012902-efprpk72	98	21	on	on	IN
cord-012902-efprpk72	98	22	univariable	univariable	JJ
cord-012902-efprpk72	98	23	analyses	analysis	NNS
cord-012902-efprpk72	98	24	.	.	.
cord-012902-efprpk72	99	1	After	after	IN
cord-012902-efprpk72	99	2	adjustment	adjustment	NN
cord-012902-efprpk72	99	3	,	,	,
cord-012902-efprpk72	99	4	associations	association	NNS
cord-012902-efprpk72	99	5	with	with	IN
cord-012902-efprpk72	99	6	IADs	iad	NNS
cord-012902-efprpk72	99	7	≥5	≥5	NNP
cord-012902-efprpk72	99	8	mmHg	mmHg	NNP
cord-012902-efprpk72	99	9	remained	remain	VBD
cord-012902-efprpk72	99	10	(	(	-LRB-
cord-012902-efprpk72	99	11	p	p	NN
cord-012902-efprpk72	99	12	=	=	SYM
cord-012902-efprpk72	99	13	0.033	0.033	CD
cord-012902-efprpk72	99	14	)	)	-RRB-
cord-012902-efprpk72	99	15	;	;	:
cord-012902-efprpk72	99	16	age	age	NN
cord-012902-efprpk72	99	17	and	and	CC
cord-012902-efprpk72	99	18	educational	educational	JJ
cord-012902-efprpk72	99	19	attainment	attainment	NN
cord-012902-efprpk72	99	20	attenuated	attenuate	VBD
cord-012902-efprpk72	99	21	the	the	DT
cord-012902-efprpk72	99	22	association	association	NN
cord-012902-efprpk72	99	23	with	with	IN
cord-012902-efprpk72	99	24	IADs	IADs	NNP
cord-012902-efprpk72	99	25	≥10	≥10	NNP
cord-012902-efprpk72	99	26	mmHg	mmHg	NNP
cord-012902-efprpk72	99	27	(	(	-LRB-
cord-012902-efprpk72	99	28	p	p	NN
cord-012902-efprpk72	99	29	=	=	SYM
cord-012902-efprpk72	99	30	0.11	0.11	CD
cord-012902-efprpk72	99	31	)	)	-RRB-
cord-012902-efprpk72	99	32	.	.	.
cord-012902-efprpk72	100	1	Conclusions	conclusion	NNS
cord-012902-efprpk72	100	2	:	:	:
cord-012902-efprpk72	101	1	We	-PRON-	PRP
cord-012902-efprpk72	101	2	present	present	VBP
cord-012902-efprpk72	101	3	the	the	DT
cord-012902-efprpk72	101	4	first	first	JJ
cord-012902-efprpk72	101	5	time	time	NN
cord-012902-efprpk72	101	6	-	-	HYPH
cord-012902-efprpk72	101	7	to	to	IN
cord-012902-efprpk72	101	8	-	-	HYPH
cord-012902-efprpk72	101	9	event	event	NN
cord-012902-efprpk72	101	10	analyses	analysis	NNS
cord-012902-efprpk72	101	11	of	of	IN
cord-012902-efprpk72	101	12	MCI	MCI	NNP
cord-012902-efprpk72	101	13	development	development	NN
cord-012902-efprpk72	101	14	with	with	IN
cord-012902-efprpk72	101	15	IAD	IAD	NNP
cord-012902-efprpk72	101	16	and	and	CC
cord-012902-efprpk72	101	17	demonstrate	demonstrate	VB
cord-012902-efprpk72	101	18	that	that	DT
cord-012902-efprpk72	101	19	systolic	systolic	JJ
cord-012902-efprpk72	101	20	IADs	iad	NNS
cord-012902-efprpk72	101	21	≥	≥	CD
cord-012902-efprpk72	101	22	5	5	CD
cord-012902-efprpk72	101	23	mmHg	mmHg	NNPS
cord-012902-efprpk72	101	24	and	and	CC
cord-012902-efprpk72	101	25	≥10	≥10	NNP
cord-012902-efprpk72	101	26	mmHg	mmHg	NNS
cord-012902-efprpk72	101	27	are	be	VBP
cord-012902-efprpk72	101	28	associated	associate	VBN
cord-012902-efprpk72	101	29	with	with	IN
cord-012902-efprpk72	101	30	MCI	MCI	NNP
cord-012902-efprpk72	101	31	onset	onset	NN
cord-012902-efprpk72	101	32	.	.	.
cord-012902-efprpk72	102	1	If	if	IN
cord-012902-efprpk72	102	2	confirmed	confirm	VBN
cord-012902-efprpk72	102	3	,	,	,
cord-012902-efprpk72	102	4	these	these	DT
cord-012902-efprpk72	102	5	findings	finding	NNS
cord-012902-efprpk72	102	6	could	could	MD
cord-012902-efprpk72	102	7	inform	inform	VB
cord-012902-efprpk72	102	8	individualised	individualised	JJ
cord-012902-efprpk72	102	9	treatment	treatment	NN
cord-012902-efprpk72	102	10	decisions	decision	NNS
cord-012902-efprpk72	102	11	to	to	TO
cord-012902-efprpk72	102	12	minimise	minimise	VB
cord-012902-efprpk72	102	13	risk	risk	NN
cord-012902-efprpk72	102	14	of	of	IN
cord-012902-efprpk72	102	15	future	future	JJ
cord-012902-efprpk72	102	16	cognitive	cognitive	JJ
cord-012902-efprpk72	102	17	decline	decline	NN
cord-012902-efprpk72	102	18	.	.	.
cord-012902-efprpk72	103	1	Disclosures	disclosure	NNS
cord-012902-efprpk72	103	2	:	:	:
cord-012902-efprpk72	103	3	None	none	NN
cord-012902-efprpk72	103	4	.	.	.
cord-012902-efprpk72	104	1	Introduction	introduction	NN
cord-012902-efprpk72	104	2	:	:	:
cord-012902-efprpk72	105	1	Forearm	forearm	NN
cord-012902-efprpk72	105	2	vasodilator	vasodilator	NN
cord-012902-efprpk72	105	3	responses	response	NNS
cord-012902-efprpk72	105	4	to	to	IN
cord-012902-efprpk72	105	5	mental	mental	JJ
cord-012902-efprpk72	105	6	stress	stress	NN
cord-012902-efprpk72	105	7	(	(	-LRB-
cord-012902-efprpk72	105	8	MS	MS	NNP
cord-012902-efprpk72	105	9	)	)	-RRB-
cord-012902-efprpk72	105	10	are	be	VBP
cord-012902-efprpk72	105	11	impaired	impair	VBN
cord-012902-efprpk72	105	12	in	in	IN
cord-012902-efprpk72	105	13	hypertensive	hypertensive	JJ
cord-012902-efprpk72	105	14	compared	compare	VBN
cord-012902-efprpk72	105	15	to	to	TO
cord-012902-efprpk72	105	16	normotensive	normotensive	JJ
cord-012902-efprpk72	105	17	individuals	individual	NNS
cord-012902-efprpk72	105	18	by	by	IN
cord-012902-efprpk72	105	19	a	a	DT
cord-012902-efprpk72	105	20	mechanism	mechanism	NN
cord-012902-efprpk72	105	21	that	that	WDT
cord-012902-efprpk72	105	22	may	may	MD
cord-012902-efprpk72	105	23	relate	relate	VB
cord-012902-efprpk72	105	24	to	to	IN
cord-012902-efprpk72	105	25	peripheral	peripheral	JJ
cord-012902-efprpk72	105	26	α−adrenergic	α−adrenergic	JJ
cord-012902-efprpk72	105	27	activity	activity	NN
cord-012902-efprpk72	105	28	antagonising	antagonise	VBG
cord-012902-efprpk72	105	29	that	that	DT
cord-012902-efprpk72	105	30	of	of	IN
cord-012902-efprpk72	105	31	neuronal	neuronal	JJ
cord-012902-efprpk72	105	32	nitric	nitric	NN
cord-012902-efprpk72	105	33	oxide	oxide	NN
cord-012902-efprpk72	105	34	[	[	-LRB-
cord-012902-efprpk72	105	35	1	1	CD
cord-012902-efprpk72	105	36	]	]	-RRB-
cord-012902-efprpk72	105	37	.	.	.
cord-012902-efprpk72	106	1	We	-PRON-	PRP
cord-012902-efprpk72	106	2	investigated	investigate	VBD
cord-012902-efprpk72	106	3	whether	whether	IN
cord-012902-efprpk72	106	4	the	the	DT
cord-012902-efprpk72	106	5	response	response	NN
cord-012902-efprpk72	106	6	to	to	IN
cord-012902-efprpk72	106	7	MS	MS	NNP
cord-012902-efprpk72	106	8	may	may	MD
cord-012902-efprpk72	106	9	be	be	VB
cord-012902-efprpk72	106	10	dependent	dependent	JJ
cord-012902-efprpk72	106	11	on	on	IN
cord-012902-efprpk72	106	12	the	the	DT
cord-012902-efprpk72	106	13	level	level	NN
cord-012902-efprpk72	106	14	of	of	IN
cord-012902-efprpk72	106	15	basal	basal	NN
cord-012902-efprpk72	106	16	sympathetic	sympathetic	JJ
cord-012902-efprpk72	106	17	activity	activity	NN
cord-012902-efprpk72	106	18	as	as	IN
cord-012902-efprpk72	106	19	measured	measure	VBN
cord-012902-efprpk72	106	20	by	by	IN
cord-012902-efprpk72	106	21	plasma	plasma	NN
cord-012902-efprpk72	106	22	concentrations	concentration	NNS
cord-012902-efprpk72	106	23	of	of	IN
cord-012902-efprpk72	106	24	normetadrenaline	normetadrenaline	NN
cord-012902-efprpk72	106	25	(	(	-LRB-
cord-012902-efprpk72	106	26	NM	NM	NNP
cord-012902-efprpk72	106	27	)	)	-RRB-
cord-012902-efprpk72	106	28	and	and	CC
cord-012902-efprpk72	106	29	how	how	WRB
cord-012902-efprpk72	106	30	responses	response	NNS
cord-012902-efprpk72	106	31	to	to	IN
cord-012902-efprpk72	106	32	slowing	slow	VBG
cord-012902-efprpk72	106	33	respiratory	respiratory	JJ
cord-012902-efprpk72	106	34	rate	rate	NN
cord-012902-efprpk72	106	35	by	by	IN
cord-012902-efprpk72	106	36	device	device	NN
cord-012902-efprpk72	106	37	guided	guide	VBN
cord-012902-efprpk72	106	38	breathing	breathing	NN
cord-012902-efprpk72	106	39	(	(	-LRB-
cord-012902-efprpk72	106	40	DGB	DGB	NNP
cord-012902-efprpk72	106	41	,	,	,
cord-012902-efprpk72	106	42	which	which	WDT
cord-012902-efprpk72	106	43	reduces	reduce	VBZ
cord-012902-efprpk72	106	44	sympathetic	sympathetic	JJ
cord-012902-efprpk72	106	45	activity	activity	NN
cord-012902-efprpk72	106	46	)	)	-RRB-
cord-012902-efprpk72	106	47	vary	vary	VBP
cord-012902-efprpk72	106	48	according	accord	VBG
cord-012902-efprpk72	106	49	to	to	IN
cord-012902-efprpk72	106	50	NM	NM	NNP
cord-012902-efprpk72	106	51	concentrations	concentration	NNS
cord-012902-efprpk72	106	52	.	.	.
cord-012902-efprpk72	107	1	Methods	method	NNS
cord-012902-efprpk72	107	2	:	:	:
cord-012902-efprpk72	107	3	Subjects	subject	NNS
cord-012902-efprpk72	107	4	with	with	IN
cord-012902-efprpk72	107	5	essential	essential	JJ
cord-012902-efprpk72	107	6	hypertension	hypertension	NN
cord-012902-efprpk72	107	7	were	be	VBD
cord-012902-efprpk72	107	8	stratified	stratify	VBN
cord-012902-efprpk72	107	9	according	accord	VBG
cord-012902-efprpk72	107	10	to	to	IN
cord-012902-efprpk72	107	11	concentrations	concentration	NNS
cord-012902-efprpk72	107	12	of	of	IN
cord-012902-efprpk72	107	13	plasma	plasma	NN
cord-012902-efprpk72	107	14	NM	NM	NNP
cord-012902-efprpk72	107	15	into	into	IN
cord-012902-efprpk72	107	16	those	those	DT
cord-012902-efprpk72	107	17	with	with	IN
cord-012902-efprpk72	107	18	low	low	JJ
cord-012902-efprpk72	107	19	NM	NM	NNP
cord-012902-efprpk72	107	20	(	(	-LRB-
cord-012902-efprpk72	107	21	≤500	≤500	NNP
cord-012902-efprpk72	107	22	pmol	pmol	NNP
cord-012902-efprpk72	107	23	/	/	SYM
cord-012902-efprpk72	107	24	L	L	NNP
cord-012902-efprpk72	107	25	)	)	-RRB-
cord-012902-efprpk72	107	26	and	and	CC
cord-012902-efprpk72	107	27	high	high	JJ
cord-012902-efprpk72	107	28	NM	NM	NNP
cord-012902-efprpk72	107	29	(	(	-LRB-
cord-012902-efprpk72	107	30	≥750	≥750	``
cord-012902-efprpk72	107	31	pmol	pmol	NNP
cord-012902-efprpk72	107	32	/	/	SYM
cord-012902-efprpk72	107	33	L	L	NNP
cord-012902-efprpk72	107	34	)	)	-RRB-
cord-012902-efprpk72	107	35	.	.	.
cord-012902-efprpk72	108	1	Forearm	forearm	NN
cord-012902-efprpk72	108	2	blood	blood	NN
cord-012902-efprpk72	108	3	flow	flow	NN
cord-012902-efprpk72	108	4	(	(	-LRB-
cord-012902-efprpk72	108	5	FBF	FBF	NNP
cord-012902-efprpk72	108	6	)	)	-RRB-
cord-012902-efprpk72	108	7	was	be	VBD
cord-012902-efprpk72	108	8	measured	measure	VBN
cord-012902-efprpk72	108	9	by	by	IN
cord-012902-efprpk72	108	10	venous	venous	JJ
cord-012902-efprpk72	108	11	occlusion	occlusion	NN
cord-012902-efprpk72	108	12	plethysmography	plethysmography	NN
cord-012902-efprpk72	108	13	after	after	IN
cord-012902-efprpk72	108	14	15	15	CD
cord-012902-efprpk72	108	15	min	min	NN
cord-012902-efprpk72	108	16	of	of	IN
cord-012902-efprpk72	108	17	rest	rest	NN
cord-012902-efprpk72	108	18	,	,	,
cord-012902-efprpk72	108	19	during	during	IN
cord-012902-efprpk72	108	20	MS	MS	NNP
cord-012902-efprpk72	108	21	elicited	elicit	VBN
cord-012902-efprpk72	108	22	by	by	IN
cord-012902-efprpk72	108	23	the	the	DT
cord-012902-efprpk72	108	24	Stroop	stroop	JJ
cord-012902-efprpk72	108	25	word	word	NN
cord-012902-efprpk72	108	26	-	-	HYPH
cord-012902-efprpk72	108	27	colour	colour	NN
cord-012902-efprpk72	108	28	test	test	NN
cord-012902-efprpk72	108	29	and	and	CC
cord-012902-efprpk72	108	30	during	during	IN
cord-012902-efprpk72	108	31	supervised	supervise	VBN
cord-012902-efprpk72	108	32	DGB	DGB	NNP
cord-012902-efprpk72	108	33	with	with	IN
cord-012902-efprpk72	108	34	breathing	breathing	NN
cord-012902-efprpk72	108	35	rate	rate	NN
cord-012902-efprpk72	108	36	<	<	XX
cord-012902-efprpk72	108	37	10	10	CD
cord-012902-efprpk72	108	38	breaths	breath	NNS
cord-012902-efprpk72	108	39	/	/	SYM
cord-012902-efprpk72	108	40	min	min	NN
cord-012902-efprpk72	108	41	.	.	.
cord-012902-efprpk72	109	1	Results	result	NNS
cord-012902-efprpk72	109	2	:	:	:
cord-012902-efprpk72	110	1	Subjects	subject	NNS
cord-012902-efprpk72	110	2	with	with	IN
cord-012902-efprpk72	110	3	high	high	JJ
cord-012902-efprpk72	110	4	NM	NM	NNP
cord-012902-efprpk72	110	5	(	(	-LRB-
cord-012902-efprpk72	110	6	n	n	NN
cord-012902-efprpk72	110	7	=	=	SYM
cord-012902-efprpk72	110	8	30	30	CD
cord-012902-efprpk72	110	9	,	,	,
cord-012902-efprpk72	110	10	15	15	CD
cord-012902-efprpk72	110	11	men	man	NNS
cord-012902-efprpk72	110	12	)	)	-RRB-
cord-012902-efprpk72	110	13	had	have	VBD
cord-012902-efprpk72	110	14	greater	great	JJR
cord-012902-efprpk72	110	15	body	body	NN
cord-012902-efprpk72	110	16	mass	mass	NN
cord-012902-efprpk72	110	17	index	index	NN
cord-012902-efprpk72	110	18	than	than	IN
cord-012902-efprpk72	110	19	those	those	DT
cord-012902-efprpk72	110	20	with	with	IN
cord-012902-efprpk72	110	21	low	low	JJ
cord-012902-efprpk72	110	22	NM	NM	NNP
cord-012902-efprpk72	110	23	(	(	-LRB-
cord-012902-efprpk72	110	24	n	n	NN
cord-012902-efprpk72	110	25	=	=	SYM
cord-012902-efprpk72	110	26	30	30	CD
cord-012902-efprpk72	110	27	,	,	,
cord-012902-efprpk72	110	28	17	17	CD
cord-012902-efprpk72	110	29	men	man	NNS
cord-012902-efprpk72	110	30	)	)	-RRB-
cord-012902-efprpk72	110	31	:	:	:
cord-012902-efprpk72	111	1	(	(	-LRB-
cord-012902-efprpk72	111	2	mean	mean	VB
cord-012902-efprpk72	111	3	±	±	NNP
cord-012902-efprpk72	111	4	SD	sd	NN
cord-012902-efprpk72	111	5	)	)	-RRB-
cord-012902-efprpk72	112	1	31	31	CD
cord-012902-efprpk72	112	2	±	±	NNP
cord-012902-efprpk72	112	3	7	7	CD
cord-012902-efprpk72	112	4	vs	vs	IN
cord-012902-efprpk72	112	5	27	27	CD
cord-012902-efprpk72	112	6	±	±	NNP
cord-012902-efprpk72	112	7	4	4	CD
cord-012902-efprpk72	112	8	kg/	kg/	NNS
cord-012902-efprpk72	113	1	m	m	LS
cord-012902-efprpk72	113	2	2	2	CD
cord-012902-efprpk72	114	1	(	(	-LRB-
cord-012902-efprpk72	114	2	p	p	NN
cord-012902-efprpk72	114	3	<	<	XX
cord-012902-efprpk72	114	4	0.05	0.05	CD
cord-012902-efprpk72	114	5	)	)	-RRB-
cord-012902-efprpk72	114	6	,	,	.
cord-012902-efprpk72	115	1	but	but	CC
cord-012902-efprpk72	115	2	the	the	DT
cord-012902-efprpk72	115	3	two	two	CD
cord-012902-efprpk72	115	4	groups	group	NNS
cord-012902-efprpk72	115	5	were	be	VBD
cord-012902-efprpk72	115	6	similar	similar	JJ
cord-012902-efprpk72	115	7	with	with	IN
cord-012902-efprpk72	115	8	respect	respect	NN
cord-012902-efprpk72	115	9	to	to	IN
cord-012902-efprpk72	115	10	age	age	NN
cord-012902-efprpk72	115	11	and	and	CC
cord-012902-efprpk72	115	12	brachial	brachial	JJ
cord-012902-efprpk72	115	13	blood	blood	NN
cord-012902-efprpk72	115	14	pressure	pressure	NN
cord-012902-efprpk72	115	15	(	(	-LRB-
cord-012902-efprpk72	115	16	BP	BP	NNP
cord-012902-efprpk72	115	17	)	)	-RRB-
cord-012902-efprpk72	115	18	.	.	.
cord-012902-efprpk72	116	1	During	during	IN
cord-012902-efprpk72	116	2	MS	MS	NNP
cord-012902-efprpk72	116	3	and	and	CC
cord-012902-efprpk72	116	4	DGB	DGB	NNP
cord-012902-efprpk72	116	5	,	,	,
cord-012902-efprpk72	116	6	changes	change	NNS
cord-012902-efprpk72	116	7	in	in	IN
cord-012902-efprpk72	116	8	BP	BP	NNP
cord-012902-efprpk72	116	9	were	be	VBD
cord-012902-efprpk72	116	10	similar	similar	JJ
cord-012902-efprpk72	116	11	in	in	IN
cord-012902-efprpk72	116	12	subjects	subject	NNS
cord-012902-efprpk72	116	13	in	in	IN
cord-012902-efprpk72	116	14	both	both	CC
cord-012902-efprpk72	116	15	low	low	JJ
cord-012902-efprpk72	116	16	NM	NM	NNP
cord-012902-efprpk72	116	17	and	and	CC
cord-012902-efprpk72	116	18	high	high	JJ
cord-012902-efprpk72	116	19	NM	NM	NNP
cord-012902-efprpk72	116	20	groups	group	NNS
cord-012902-efprpk72	116	21	.	.	.
cord-012902-efprpk72	117	1	MS	MS	NNP
cord-012902-efprpk72	117	2	increased	increase	VBD
cord-012902-efprpk72	117	3	FBF	FBF	NNP
cord-012902-efprpk72	117	4	in	in	IN
cord-012902-efprpk72	117	5	both	both	DT
cord-012902-efprpk72	117	6	groups	group	NNS
cord-012902-efprpk72	117	7	but	but	CC
cord-012902-efprpk72	117	8	the	the	DT
cord-012902-efprpk72	117	9	response	response	NN
cord-012902-efprpk72	117	10	in	in	IN
cord-012902-efprpk72	117	11	high	high	JJ
cord-012902-efprpk72	117	12	NM	NM	NNP
cord-012902-efprpk72	117	13	was	be	VBD
cord-012902-efprpk72	117	14	impaired	impair	VBN
cord-012902-efprpk72	117	15	as	as	IN
cord-012902-efprpk72	117	16	compared	compare	VBN
cord-012902-efprpk72	117	17	to	to	IN
cord-012902-efprpk72	117	18	subjects	subject	NNS
cord-012902-efprpk72	117	19	with	with	IN
cord-012902-efprpk72	117	20	low	low	JJ
cord-012902-efprpk72	117	21	NM	NM	NNP
cord-012902-efprpk72	117	22	(	(	-LRB-
cord-012902-efprpk72	117	23	34	34	CD
cord-012902-efprpk72	117	24	±	±	NNP
cord-012902-efprpk72	117	25	3	3	CD
cord-012902-efprpk72	117	26	vs.	vs.	NN
cord-012902-efprpk72	117	27	49	49	CD
cord-012902-efprpk72	117	28	±	±	CD
cord-012902-efprpk72	117	29	3	3	CD
cord-012902-efprpk72	117	30	%	%	NN
cord-012902-efprpk72	117	31	,	,	,
cord-012902-efprpk72	117	32	p	p	NN
cord-012902-efprpk72	117	33	<	<	XX
cord-012902-efprpk72	117	34	0.05	0.05	CD
cord-012902-efprpk72	117	35	)	)	-RRB-
cord-012902-efprpk72	117	36	.	.	.
cord-012902-efprpk72	118	1	DGB	DGB	NNP
cord-012902-efprpk72	118	2	increased	increase	VBD
cord-012902-efprpk72	118	3	forearm	forearm	NN
cord-012902-efprpk72	118	4	vascular	vascular	JJ
cord-012902-efprpk72	118	5	resistance	resistance	NN
cord-012902-efprpk72	118	6	to	to	IN
cord-012902-efprpk72	118	7	a	a	DT
cord-012902-efprpk72	118	8	lesser	less	JJR
cord-012902-efprpk72	118	9	extent	extent	NN
cord-012902-efprpk72	118	10	in	in	IN
cord-012902-efprpk72	118	11	subjects	subject	NNS
cord-012902-efprpk72	118	12	with	with	IN
cord-012902-efprpk72	118	13	high	high	JJ
cord-012902-efprpk72	118	14	compared	compare	VBN
cord-012902-efprpk72	118	15	to	to	IN
cord-012902-efprpk72	118	16	low	low	JJ
cord-012902-efprpk72	118	17	NM	NM	NNP
cord-012902-efprpk72	118	18	(	(	-LRB-
cord-012902-efprpk72	118	19	1.21	1.21	CD
cord-012902-efprpk72	118	20	±	±	CD
cord-012902-efprpk72	118	21	7.95	7.95	CD
cord-012902-efprpk72	118	22	vs	vs	IN
cord-012902-efprpk72	118	23	5.50	5.50	CD
cord-012902-efprpk72	118	24	±	±	CD
cord-012902-efprpk72	118	25	6.32	6.32	CD
cord-012902-efprpk72	118	26	mmHg.100	mmHg.100	NNS
cord-012902-efprpk72	118	27	mL	ml	NN
cord-012902-efprpk72	118	28	/	/	SYM
cord-012902-efprpk72	118	29	mL	ml	NN
cord-012902-efprpk72	118	30	,	,	,
cord-012902-efprpk72	118	31	p	p	NN
cord-012902-efprpk72	118	32	<	<	XX
cord-012902-efprpk72	118	33	0.05	0.05	CD
cord-012902-efprpk72	118	34	)	)	-RRB-
cord-012902-efprpk72	118	35	.	.	.
cord-012902-efprpk72	119	1	Conclusions	conclusion	NNS
cord-012902-efprpk72	119	2	:	:	:
cord-012902-efprpk72	120	1	These	these	DT
cord-012902-efprpk72	120	2	results	result	NNS
cord-012902-efprpk72	120	3	are	be	VBP
cord-012902-efprpk72	120	4	consistent	consistent	JJ
cord-012902-efprpk72	120	5	with	with	IN
cord-012902-efprpk72	120	6	greater	great	JJR
cord-012902-efprpk72	120	7	sympathetic	sympathetic	JJ
cord-012902-efprpk72	120	8	vascular	vascular	JJ
cord-012902-efprpk72	120	9	tone	tone	NN
cord-012902-efprpk72	120	10	in	in	IN
cord-012902-efprpk72	120	11	patients	patient	NNS
cord-012902-efprpk72	120	12	with	with	IN
cord-012902-efprpk72	120	13	higher	high	JJR
cord-012902-efprpk72	120	14	NM	NM	NNP
cord-012902-efprpk72	120	15	that	that	WDT
cord-012902-efprpk72	120	16	antagonises	antagonise	VBZ
cord-012902-efprpk72	120	17	forearm	forearm	NN
cord-012902-efprpk72	120	18	vascular	vascular	JJ
cord-012902-efprpk72	120	19	responses	response	NNS
cord-012902-efprpk72	120	20	to	to	IN
cord-012902-efprpk72	120	21	MS	MS	NNP
cord-012902-efprpk72	120	22	.	.	.
cord-012902-efprpk72	121	1	Circulating	circulate	VBG
cord-012902-efprpk72	121	2	concentrations	concentration	NNS
cord-012902-efprpk72	121	3	of	of	IN
cord-012902-efprpk72	121	4	NM	NM	NNP
cord-012902-efprpk72	121	5	may	may	MD
cord-012902-efprpk72	121	6	identify	identify	VB
cord-012902-efprpk72	121	7	subjects	subject	NNS
cord-012902-efprpk72	121	8	with	with	IN
cord-012902-efprpk72	121	9	impaired	impaired	JJ
cord-012902-efprpk72	121	10	neuronal	neuronal	JJ
cord-012902-efprpk72	121	11	nitric	nitric	NN
cord-012902-efprpk72	121	12	oxide	oxide	NN
cord-012902-efprpk72	121	13	signalling	signalling	NN
cord-012902-efprpk72	121	14	.	.	.
cord-012902-efprpk72	122	1	Disclosures	disclosure	NNS
cord-012902-efprpk72	122	2	:	:	:
cord-012902-efprpk72	122	3	None	none	NN
cord-012902-efprpk72	122	4	.	.	.
cord-012902-efprpk72	123	1	Introduction	introduction	NN
cord-012902-efprpk72	123	2	:	:	:
cord-012902-efprpk72	124	1	Most	Most	JJS
cord-012902-efprpk72	124	2	rare	rare	JJ
cord-012902-efprpk72	124	3	monogenic	monogenic	JJ
cord-012902-efprpk72	124	4	causes	cause	NNS
cord-012902-efprpk72	124	5	of	of	IN
cord-012902-efprpk72	124	6	hypertension	hypertension	NN
cord-012902-efprpk72	124	7	and	and	CC
cord-012902-efprpk72	124	8	many	many	JJ
cord-012902-efprpk72	124	9	hypertensive	hypertensive	JJ
cord-012902-efprpk72	124	10	subjects	subject	NNS
cord-012902-efprpk72	124	11	with	with	IN
cord-012902-efprpk72	124	12	primary	primary	JJ
cord-012902-efprpk72	124	13	polygenic	polygenic	JJ
cord-012902-efprpk72	124	14	hypertension	hypertension	NN
cord-012902-efprpk72	124	15	,	,	,
cord-012902-efprpk72	124	16	particularly	particularly	RB
cord-012902-efprpk72	124	17	those	those	DT
cord-012902-efprpk72	124	18	of	of	IN
cord-012902-efprpk72	124	19	African	african	JJ
cord-012902-efprpk72	124	20	ancestry	ancestry	NN
cord-012902-efprpk72	124	21	,	,	,
cord-012902-efprpk72	124	22	are	be	VBP
cord-012902-efprpk72	124	23	characterised	characterise	VBN
cord-012902-efprpk72	124	24	by	by	IN
cord-012902-efprpk72	124	25	low	low	JJ
cord-012902-efprpk72	124	26	plasma	plasma	NN
cord-012902-efprpk72	124	27	renin	renin	NN
cord-012902-efprpk72	124	28	thought	thought	NN
cord-012902-efprpk72	124	29	to	to	TO
cord-012902-efprpk72	124	30	reflect	reflect	VB
cord-012902-efprpk72	124	31	sodium	sodium	NN
cord-012902-efprpk72	124	32	retention	retention	NN
cord-012902-efprpk72	124	33	by	by	IN
cord-012902-efprpk72	124	34	the	the	DT
cord-012902-efprpk72	124	35	kidney	kidney	NN
cord-012902-efprpk72	124	36	.	.	.
cord-012902-efprpk72	125	1	A	a	DT
cord-012902-efprpk72	125	2	novel	novel	NN
cord-012902-efprpk72	125	3	"	"	``
cord-012902-efprpk72	125	4	salt	salt	NN
cord-012902-efprpk72	125	5	blood	blood	NN
cord-012902-efprpk72	125	6	test	test	NN
cord-012902-efprpk72	125	7	"	"	''
cord-012902-efprpk72	125	8	(	(	-LRB-
cord-012902-efprpk72	125	9	SBT	SBT	NNP
cord-012902-efprpk72	125	10	)	)	-RRB-
cord-012902-efprpk72	125	11	measures	measure	VBZ
cord-012902-efprpk72	125	12	a	a	DT
cord-012902-efprpk72	125	13	change	change	NN
cord-012902-efprpk72	125	14	in	in	IN
cord-012902-efprpk72	125	15	the	the	DT
cord-012902-efprpk72	125	16	erythrocyte	erythrocyte	NN
cord-012902-efprpk72	125	17	glycocalyx	glycocalyx	NN
cord-012902-efprpk72	125	18	that	that	WDT
cord-012902-efprpk72	125	19	may	may	MD
cord-012902-efprpk72	125	20	reflect	reflect	VB
cord-012902-efprpk72	125	21	sodium	sodium	NN
cord-012902-efprpk72	125	22	damage	damage	NN
cord-012902-efprpk72	125	23	to	to	IN
cord-012902-efprpk72	125	24	the	the	DT
cord-012902-efprpk72	125	25	endothelium	endothelium	NN
cord-012902-efprpk72	125	26	[	[	-LRB-
cord-012902-efprpk72	125	27	1	1	CD
cord-012902-efprpk72	125	28	]	]	-RRB-
cord-012902-efprpk72	125	29	.	.	.
cord-012902-efprpk72	126	1	We	-PRON-	PRP
cord-012902-efprpk72	126	2	compared	compare	VBD
cord-012902-efprpk72	126	3	values	value	NNS
cord-012902-efprpk72	126	4	of	of	IN
cord-012902-efprpk72	126	5	the	the	DT
cord-012902-efprpk72	126	6	SBT	SBT	NNP
cord-012902-efprpk72	126	7	in	in	IN
cord-012902-efprpk72	126	8	normotensive	normotensive	JJ
cord-012902-efprpk72	126	9	subjects	subject	NNS
cord-012902-efprpk72	126	10	and	and	CC
cord-012902-efprpk72	126	11	in	in	IN
cord-012902-efprpk72	126	12	hypertensive	hypertensive	JJ
cord-012902-efprpk72	126	13	subjects	subject	NNS
cord-012902-efprpk72	126	14	with	with	IN
cord-012902-efprpk72	126	15	a	a	DT
cord-012902-efprpk72	126	16	distribution	distribution	NN
cord-012902-efprpk72	126	17	of	of	IN
cord-012902-efprpk72	126	18	renin	renin	NN
cord-012902-efprpk72	126	19	across	across	IN
cord-012902-efprpk72	126	20	the	the	DT
cord-012902-efprpk72	126	21	physiological	physiological	JJ
cord-012902-efprpk72	126	22	range	range	NN
cord-012902-efprpk72	126	23	.	.	.
cord-012902-efprpk72	127	1	Methods	method	NNS
cord-012902-efprpk72	127	2	:	:	:
cord-012902-efprpk72	127	3	We	-PRON-	PRP
cord-012902-efprpk72	127	4	studied	study	VBD
cord-012902-efprpk72	127	5	90	90	CD
cord-012902-efprpk72	127	6	hypertensive	hypertensive	JJ
cord-012902-efprpk72	127	7	subjects	subject	NNS
cord-012902-efprpk72	127	8	and	and	CC
cord-012902-efprpk72	127	9	10	10	CD
cord-012902-efprpk72	127	10	normotensive	normotensive	JJ
cord-012902-efprpk72	127	11	healthy	healthy	JJ
cord-012902-efprpk72	127	12	volunteers	volunteer	NNS
cord-012902-efprpk72	127	13	.	.	.
cord-012902-efprpk72	128	1	The	the	DT
cord-012902-efprpk72	128	2	SBT	SBT	NNP
cord-012902-efprpk72	128	3	was	be	VBD
cord-012902-efprpk72	128	4	measured	measure	VBN
cord-012902-efprpk72	128	5	in	in	IN
cord-012902-efprpk72	128	6	freshly	freshly	RB
cord-012902-efprpk72	128	7	drawn	draw	VBN
cord-012902-efprpk72	128	8	venous	venous	JJ
cord-012902-efprpk72	128	9	blood	blood	NN
cord-012902-efprpk72	128	10	using	use	VBG
cord-012902-efprpk72	128	11	commercially	commercially	RB
cord-012902-efprpk72	128	12	available	available	JJ
cord-012902-efprpk72	128	13	kits	kit	NNS
cord-012902-efprpk72	128	14	obtained	obtain	VBN
cord-012902-efprpk72	128	15	from	from	IN
cord-012902-efprpk72	128	16	CARE	CARE	NNP
cord-012902-efprpk72	128	17	Diagnostica	Diagnostica	NNP
cord-012902-efprpk72	128	18	,	,	,
cord-012902-efprpk72	128	19	Voerde	Voerde	NNP
cord-012902-efprpk72	128	20	,	,	,
cord-012902-efprpk72	128	21	Germany	Germany	NNP
cord-012902-efprpk72	128	22	.	.	.
cord-012902-efprpk72	129	1	Brachial	brachial	JJ
cord-012902-efprpk72	129	2	blood	blood	NN
cord-012902-efprpk72	129	3	pressure	pressure	NN
cord-012902-efprpk72	129	4	(	(	-LRB-
cord-012902-efprpk72	129	5	BP	BP	NNP
cord-012902-efprpk72	129	6	)	)	-RRB-
cord-012902-efprpk72	129	7	,	,	,
cord-012902-efprpk72	129	8	biochemistry	biochemistry	NN
cord-012902-efprpk72	129	9	(	(	-LRB-
cord-012902-efprpk72	129	10	including	include	VBG
cord-012902-efprpk72	129	11	renin	renin	NN
cord-012902-efprpk72	129	12	and	and	CC
cord-012902-efprpk72	129	13	aldosterone	aldosterone	NN
cord-012902-efprpk72	129	14	)	)	-RRB-
cord-012902-efprpk72	129	15	and	and	CC
cord-012902-efprpk72	129	16	24	24	CD
cord-012902-efprpk72	129	17	h	h	NN
cord-012902-efprpk72	129	18	urine	urine	NN
cord-012902-efprpk72	129	19	collection	collection	NN
cord-012902-efprpk72	129	20	for	for	IN
cord-012902-efprpk72	129	21	the	the	DT
cord-012902-efprpk72	129	22	estimation	estimation	NN
cord-012902-efprpk72	129	23	of	of	IN
cord-012902-efprpk72	129	24	dietary	dietary	JJ
cord-012902-efprpk72	129	25	salt	salt	NN
cord-012902-efprpk72	129	26	intake	intake	NN
cord-012902-efprpk72	129	27	were	be	VBD
cord-012902-efprpk72	129	28	performed	perform	VBN
cord-012902-efprpk72	129	29	in	in	IN
cord-012902-efprpk72	129	30	every	every	DT
cord-012902-efprpk72	129	31	subject	subject	NN
cord-012902-efprpk72	129	32	.	.	.
cord-012902-efprpk72	130	1	Results	result	NNS
cord-012902-efprpk72	130	2	:	:	:
cord-012902-efprpk72	131	1	The	the	DT
cord-012902-efprpk72	131	2	average	average	JJ
cord-012902-efprpk72	131	3	systolic	systolic	JJ
cord-012902-efprpk72	131	4	blood	blood	NN
cord-012902-efprpk72	131	5	pressure	pressure	NN
cord-012902-efprpk72	131	6	of	of	IN
cord-012902-efprpk72	131	7	the	the	DT
cord-012902-efprpk72	131	8	hypertensive	hypertensive	JJ
cord-012902-efprpk72	131	9	subjects	subject	NNS
cord-012902-efprpk72	131	10	was	be	VBD
cord-012902-efprpk72	131	11	(	(	-LRB-
cord-012902-efprpk72	131	12	mean	mean	JJ
cord-012902-efprpk72	131	13	±	±	NNP
cord-012902-efprpk72	131	14	SD	SD	NNP
cord-012902-efprpk72	131	15	)	)	-RRB-
cord-012902-efprpk72	131	16	141.28	141.28	CD
cord-012902-efprpk72	131	17	±	±	CD
cord-012902-efprpk72	131	18	15.4	15.4	CD
cord-012902-efprpk72	131	19	mmHg	mmHg	NNS
cord-012902-efprpk72	131	20	.	.	.
cord-012902-efprpk72	132	1	The	the	DT
cord-012902-efprpk72	132	2	SBT	SBT	NNP
cord-012902-efprpk72	132	3	was	be	VBD
cord-012902-efprpk72	132	4	greater	great	JJR
cord-012902-efprpk72	132	5	in	in	IN
cord-012902-efprpk72	132	6	hypertensive	hypertensive	JJ
cord-012902-efprpk72	132	7	subjects	subject	NNS
cord-012902-efprpk72	132	8	than	than	IN
cord-012902-efprpk72	132	9	in	in	IN
cord-012902-efprpk72	132	10	normotensive	normotensive	JJ
cord-012902-efprpk72	132	11	subjects	subject	NNS
cord-012902-efprpk72	132	12	(	(	-LRB-
cord-012902-efprpk72	132	13	129	129	CD
cord-012902-efprpk72	132	14	±	±	CD
cord-012902-efprpk72	132	15	39	39	CD
cord-012902-efprpk72	132	16	%	%	NN
cord-012902-efprpk72	132	17	vs.	vs.	NN
cord-012902-efprpk72	132	18	97	97	CD
cord-012902-efprpk72	132	19	±	±	CD
cord-012902-efprpk72	132	20	34	34	CD
cord-012902-efprpk72	132	21	%	%	NN
cord-012902-efprpk72	132	22	,	,	,
cord-012902-efprpk72	132	23	mean	mean	JJ
cord-012902-efprpk72	132	24	±	±	NNP
cord-012902-efprpk72	132	25	SD	SD	NNP
cord-012902-efprpk72	132	26	,	,	,
cord-012902-efprpk72	132	27	p	p	NN
cord-012902-efprpk72	132	28	<	<	XX
cord-012902-efprpk72	132	29	0.05	0.05	CD
cord-012902-efprpk72	132	30	)	)	-RRB-
cord-012902-efprpk72	132	31	and	and	CC
cord-012902-efprpk72	132	32	tended	tend	VBD
cord-012902-efprpk72	132	33	to	to	TO
cord-012902-efprpk72	132	34	be	be	VB
cord-012902-efprpk72	132	35	greater	great	JJR
cord-012902-efprpk72	132	36	in	in	IN
cord-012902-efprpk72	132	37	those	those	DT
cord-012902-efprpk72	132	38	in	in	IN
cord-012902-efprpk72	132	39	the	the	DT
cord-012902-efprpk72	132	40	lowest	low	JJS
cord-012902-efprpk72	132	41	quartile	quartile	NN
cord-012902-efprpk72	132	42	compared	compare	VBN
cord-012902-efprpk72	132	43	to	to	IN
cord-012902-efprpk72	132	44	the	the	DT
cord-012902-efprpk72	132	45	highest	high	JJS
cord-012902-efprpk72	132	46	quartile	quartile	NN
cord-012902-efprpk72	132	47	of	of	IN
cord-012902-efprpk72	132	48	the	the	DT
cord-012902-efprpk72	132	49	distribution	distribution	NN
cord-012902-efprpk72	132	50	of	of	IN
cord-012902-efprpk72	132	51	renin	renin	NN
cord-012902-efprpk72	132	52	(	(	-LRB-
cord-012902-efprpk72	132	53	140	140	CD
cord-012902-efprpk72	132	54	±	±	CD
cord-012902-efprpk72	132	55	44	44	CD
cord-012902-efprpk72	132	56	%	%	NN
cord-012902-efprpk72	132	57	vs.	vs.	NN
cord-012902-efprpk72	132	58	114	114	CD
cord-012902-efprpk72	132	59	±	±	CD
cord-012902-efprpk72	132	60	37	37	CD
cord-012902-efprpk72	132	61	%	%	NN
cord-012902-efprpk72	132	62	for	for	IN
cord-012902-efprpk72	132	63	low	low	JJ
cord-012902-efprpk72	132	64	vs.	vs.	IN
cord-012902-efprpk72	132	65	high	high	JJ
cord-012902-efprpk72	132	66	renin	renin	NN
cord-012902-efprpk72	132	67	hypertensives	hypertensive	NNS
cord-012902-efprpk72	132	68	,	,	,
cord-012902-efprpk72	132	69	p	p	NN
cord-012902-efprpk72	132	70	=	=	SYM
cord-012902-efprpk72	132	71	0.024	0.024	CD
cord-012902-efprpk72	132	72	)	)	-RRB-
cord-012902-efprpk72	132	73	.	.	.
cord-012902-efprpk72	133	1	Values	value	NNS
cord-012902-efprpk72	133	2	of	of	IN
cord-012902-efprpk72	133	3	the	the	DT
cord-012902-efprpk72	133	4	SBT	SBT	NNP
cord-012902-efprpk72	133	5	were	be	VBD
cord-012902-efprpk72	133	6	related	relate	VBN
cord-012902-efprpk72	133	7	to	to	IN
cord-012902-efprpk72	133	8	24h	24h	CD
cord-012902-efprpk72	133	9	urinary	urinary	JJ
cord-012902-efprpk72	133	10	sodium	sodium	NN
cord-012902-efprpk72	133	11	excretion	excretion	NN
cord-012902-efprpk72	133	12	with	with	IN
cord-012902-efprpk72	133	13	subjects	subject	NNS
cord-012902-efprpk72	133	14	in	in	IN
cord-012902-efprpk72	133	15	the	the	DT
cord-012902-efprpk72	133	16	highest	high	JJS
cord-012902-efprpk72	133	17	tertile	tertile	NN
cord-012902-efprpk72	133	18	of	of	IN
cord-012902-efprpk72	133	19	SBT%	SBT%	NNP
cord-012902-efprpk72	133	20	having	have	VBG
cord-012902-efprpk72	133	21	higher	high	JJR
cord-012902-efprpk72	133	22	24h	24h	CD
cord-012902-efprpk72	133	23	urinary	urinary	JJ
cord-012902-efprpk72	133	24	sodium	sodium	NN
cord-012902-efprpk72	133	25	excretion	excretion	NN
cord-012902-efprpk72	133	26	(	(	-LRB-
cord-012902-efprpk72	133	27	149.7	149.7	CD
cord-012902-efprpk72	133	28	±	±	NNP
cord-012902-efprpk72	133	29	73.6	73.6	CD
cord-012902-efprpk72	133	30	mmol/24	mmol/24	NNP
cord-012902-efprpk72	133	31	h	h	NNP
cord-012902-efprpk72	133	32	vs	vs	IN
cord-012902-efprpk72	133	33	110.1	110.1	CD
cord-012902-efprpk72	133	34	±	±	CD
cord-012902-efprpk72	133	35	67.2	67.2	CD
cord-012902-efprpk72	133	36	mmol/24	mmol/24	NNP
cord-012902-efprpk72	133	37	h	h	NNP
cord-012902-efprpk72	133	38	,	,	,
cord-012902-efprpk72	133	39	p	p	NN
cord-012902-efprpk72	133	40	=	=	SYM
cord-012902-efprpk72	133	41	0.043	0.043	CD
cord-012902-efprpk72	133	42	for	for	IN
cord-012902-efprpk72	133	43	highest	high	JJS
cord-012902-efprpk72	133	44	compared	compare	VBN
cord-012902-efprpk72	133	45	to	to	IN
cord-012902-efprpk72	133	46	lowest	low	JJS
cord-012902-efprpk72	133	47	tertile	tertile	NNP
cord-012902-efprpk72	133	48	)	)	-RRB-
cord-012902-efprpk72	133	49	with	with	IN
cord-012902-efprpk72	133	50	no	no	DT
cord-012902-efprpk72	133	51	difference	difference	NN
cord-012902-efprpk72	133	52	in	in	IN
cord-012902-efprpk72	133	53	plasma	plasma	NN
cord-012902-efprpk72	133	54	sodium	sodium	NN
cord-012902-efprpk72	133	55	and	and	CC
cord-012902-efprpk72	133	56	kidney	kidney	NN
cord-012902-efprpk72	133	57	function	function	NN
cord-012902-efprpk72	133	58	.	.	.
cord-012902-efprpk72	134	1	Conclusions	conclusion	NNS
cord-012902-efprpk72	134	2	:	:	:
cord-012902-efprpk72	135	1	The	the	DT
cord-012902-efprpk72	135	2	SBT	SBT	NNP
cord-012902-efprpk72	135	3	is	be	VBZ
cord-012902-efprpk72	135	4	elevated	elevate	VBN
cord-012902-efprpk72	135	5	in	in	IN
cord-012902-efprpk72	135	6	hypertensive	hypertensive	JJ
cord-012902-efprpk72	135	7	compared	compare	VBN
cord-012902-efprpk72	135	8	to	to	IN
cord-012902-efprpk72	135	9	normotensives	normotensives	FW
cord-012902-efprpk72	135	10	subjects	subject	NNS
cord-012902-efprpk72	135	11	and	and	CC
cord-012902-efprpk72	135	12	may	may	MD
cord-012902-efprpk72	135	13	be	be	VB
cord-012902-efprpk72	135	14	a	a	DT
cord-012902-efprpk72	135	15	useful	useful	JJ
cord-012902-efprpk72	135	16	marker	marker	NN
cord-012902-efprpk72	135	17	of	of	IN
cord-012902-efprpk72	135	18	damage	damage	NN
cord-012902-efprpk72	135	19	to	to	IN
cord-012902-efprpk72	135	20	cell	cell	NN
cord-012902-efprpk72	135	21	membranes	membrane	NNS
cord-012902-efprpk72	135	22	by	by	IN
cord-012902-efprpk72	135	23	sodium	sodium	NN
cord-012902-efprpk72	135	24	.	.	.
cord-012902-efprpk72	136	1	Disclosures	disclosure	NNS
cord-012902-efprpk72	136	2	:	:	:
cord-012902-efprpk72	136	3	None	none	NN
cord-012902-efprpk72	136	4	.	.	.
cord-012902-efprpk72	137	1	Introduction	introduction	NN
cord-012902-efprpk72	137	2	:	:	:
cord-012902-efprpk72	137	3	Uncontrolled	uncontrolled	JJ
cord-012902-efprpk72	137	4	blood	blood	NN
cord-012902-efprpk72	137	5	pressure	pressure	NN
cord-012902-efprpk72	137	6	(	(	-LRB-
cord-012902-efprpk72	137	7	BP	BP	NNP
cord-012902-efprpk72	137	8	)	)	-RRB-
cord-012902-efprpk72	137	9	is	be	VBZ
cord-012902-efprpk72	137	10	an	an	DT
cord-012902-efprpk72	137	11	important	important	JJ
cord-012902-efprpk72	137	12	modifiable	modifiable	JJ
cord-012902-efprpk72	137	13	risk	risk	NN
cord-012902-efprpk72	137	14	factor	factor	NN
cord-012902-efprpk72	137	15	for	for	IN
cord-012902-efprpk72	137	16	recurrent	recurrent	JJ
cord-012902-efprpk72	137	17	stroke	stroke	NN
cord-012902-efprpk72	137	18	.	.	.
cord-012902-efprpk72	138	1	Secondary	secondary	JJ
cord-012902-efprpk72	138	2	prevention	prevention	NN
cord-012902-efprpk72	138	3	measures	measure	NNS
cord-012902-efprpk72	138	4	when	when	WRB
cord-012902-efprpk72	138	5	implemented	implement	VBN
cord-012902-efprpk72	138	6	can	can	MD
cord-012902-efprpk72	138	7	reduce	reduce	VB
cord-012902-efprpk72	138	8	stroke	stroke	NN
cord-012902-efprpk72	138	9	re	re	NN
cord-012902-efprpk72	138	10	-	-	NN
cord-012902-efprpk72	138	11	occurrence	occurrence	NN
cord-012902-efprpk72	138	12	by	by	IN
cord-012902-efprpk72	138	13	80	80	CD
cord-012902-efprpk72	138	14	%	%	NN
cord-012902-efprpk72	138	15	.	.	.
cord-012902-efprpk72	139	1	However	however	RB
cord-012902-efprpk72	139	2	,	,	,
cord-012902-efprpk72	139	3	hypertension	hypertension	NN
cord-012902-efprpk72	139	4	control	control	NN
cord-012902-efprpk72	139	5	rates	rate	NNS
cord-012902-efprpk72	139	6	remain	remain	VBP
cord-012902-efprpk72	139	7	sub	sub	JJ
cord-012902-efprpk72	139	8	-	-	JJ
cord-012902-efprpk72	139	9	optimal	optimal	JJ
cord-012902-efprpk72	139	10	,	,	,
cord-012902-efprpk72	139	11	and	and	CC
cord-012902-efprpk72	139	12	little	little	JJ
cord-012902-efprpk72	139	13	data	datum	NNS
cord-012902-efprpk72	139	14	is	be	VBZ
cord-012902-efprpk72	139	15	available	available	JJ
cord-012902-efprpk72	139	16	from	from	IN
cord-012902-efprpk72	139	17	primary	primary	JJ
cord-012902-efprpk72	139	18	care	care	NN
cord-012902-efprpk72	139	19	where	where	WRB
cord-012902-efprpk72	139	20	most	most	JJS
cord-012902-efprpk72	139	21	management	management	NN
cord-012902-efprpk72	139	22	occurs	occur	VBZ
cord-012902-efprpk72	139	23	.	.	.
cord-012902-efprpk72	140	1	This	this	DT
cord-012902-efprpk72	140	2	study	study	NN
cord-012902-efprpk72	140	3	aimed	aim	VBD
cord-012902-efprpk72	140	4	to	to	TO
cord-012902-efprpk72	140	5	describe	describe	VB
cord-012902-efprpk72	140	6	BP	BP	NNP
cord-012902-efprpk72	140	7	control	control	NN
cord-012902-efprpk72	140	8	in	in	IN
cord-012902-efprpk72	140	9	primary	primary	JJ
cord-012902-efprpk72	140	10	carebased	carebased	JJ
cord-012902-efprpk72	140	11	patients	patient	NNS
cord-012902-efprpk72	140	12	with	with	IN
cord-012902-efprpk72	140	13	a	a	DT
cord-012902-efprpk72	140	14	previous	previous	JJ
cord-012902-efprpk72	140	15	stroke	stroke	NN
cord-012902-efprpk72	140	16	or	or	CC
cord-012902-efprpk72	140	17	transient	transient	JJ
cord-012902-efprpk72	140	18	ischaemic	ischaemic	JJ
cord-012902-efprpk72	140	19	attack	attack	NN
cord-012902-efprpk72	140	20	(	(	-LRB-
cord-012902-efprpk72	140	21	TIA	TIA	NNP
cord-012902-efprpk72	140	22	)	)	-RRB-
cord-012902-efprpk72	140	23	in	in	IN
cord-012902-efprpk72	140	24	Ireland	Ireland	NNP
cord-012902-efprpk72	140	25	,	,	,
cord-012902-efprpk72	140	26	and	and	CC
cord-012902-efprpk72	140	27	to	to	TO
cord-012902-efprpk72	140	28	concurrently	concurrently	RB
cord-012902-efprpk72	140	29	examine	examine	VB
cord-012902-efprpk72	140	30	antihypertensive	antihypertensive	JJ
cord-012902-efprpk72	140	31	medication	medication	NN
cord-012902-efprpk72	140	32	-	-	HYPH
cord-012902-efprpk72	140	33	dosing	dosing	NN
cord-012902-efprpk72	140	34	.	.	.
cord-012902-efprpk72	141	1	Methods	method	NNS
cord-012902-efprpk72	141	2	:	:	:
cord-012902-efprpk72	141	3	To	to	TO
cord-012902-efprpk72	141	4	assess	assess	VB
cord-012902-efprpk72	141	5	BP	BP	NNP
cord-012902-efprpk72	141	6	control	control	NN
cord-012902-efprpk72	141	7	,	,	,
cord-012902-efprpk72	141	8	we	-PRON-	PRP
cord-012902-efprpk72	141	9	extracted	extract	VBD
cord-012902-efprpk72	141	10	the	the	DT
cord-012902-efprpk72	141	11	most	most	RBS
cord-012902-efprpk72	141	12	recent	recent	JJ
cord-012902-efprpk72	141	13	office	office	NN
cord-012902-efprpk72	141	14	-	-	HYPH
cord-012902-efprpk72	141	15	based	base	VBN
cord-012902-efprpk72	141	16	reading	reading	NN
cord-012902-efprpk72	141	17	from	from	IN
cord-012902-efprpk72	141	18	the	the	DT
cord-012902-efprpk72	141	19	individual	individual	JJ
cord-012902-efprpk72	141	20	health	health	NN
cord-012902-efprpk72	141	21	care	care	NN
cord-012902-efprpk72	141	22	records	record	NNS
cord-012902-efprpk72	141	23	of	of	IN
cord-012902-efprpk72	141	24	patients	patient	NNS
cord-012902-efprpk72	141	25	with	with	IN
cord-012902-efprpk72	141	26	a	a	DT
cord-012902-efprpk72	141	27	previous	previous	JJ
cord-012902-efprpk72	141	28	stroke	stroke	NN
cord-012902-efprpk72	141	29	or	or	CC
cord-012902-efprpk72	141	30	TIA	TIA	NNP
cord-012902-efprpk72	141	31	.	.	.
cord-012902-efprpk72	142	1	We	-PRON-	PRP
cord-012902-efprpk72	142	2	compared	compare	VBD
cord-012902-efprpk72	142	3	this	this	DT
cord-012902-efprpk72	142	4	with	with	IN
cord-012902-efprpk72	142	5	both	both	CC
cord-012902-efprpk72	142	6	the	the	DT
cord-012902-efprpk72	142	7	European	European	NNP
cord-012902-efprpk72	142	8	Society	Society	NNP
cord-012902-efprpk72	142	9	of	of	IN
cord-012902-efprpk72	142	10	Hypertension	Hypertension	NNP
cord-012902-efprpk72	142	11	(	(	-LRB-
cord-012902-efprpk72	142	12	ESH	ESH	NNP
cord-012902-efprpk72	142	13	)	)	-RRB-
cord-012902-efprpk72	142	14	goal	goal	NN
cord-012902-efprpk72	142	15	of	of	IN
cord-012902-efprpk72	142	16	BP	BP	NNP
cord-012902-efprpk72	142	17	<	<	XX
cord-012902-efprpk72	142	18	140/90	140/90	CD
cord-012902-efprpk72	142	19	mmHg	mmHg	NNS
cord-012902-efprpk72	142	20	,	,	,
cord-012902-efprpk72	142	21	and	and	CC
cord-012902-efprpk72	142	22	the	the	DT
cord-012902-efprpk72	142	23	American	American	NNP
cord-012902-efprpk72	142	24	Heart	Heart	NNP
cord-012902-efprpk72	142	25	Association	Association	NNP
cord-012902-efprpk72	142	26	(	(	-LRB-
cord-012902-efprpk72	142	27	AHA	AHA	NNP
cord-012902-efprpk72	142	28	)	)	-RRB-
cord-012902-efprpk72	142	29	goal	goal	NN
cord-012902-efprpk72	142	30	of	of	IN
cord-012902-efprpk72	143	1	BP	BP	NNP
cord-012902-efprpk72	143	2	<	<	XX
cord-012902-efprpk72	143	3	130/80	130/80	CD
cord-012902-efprpk72	143	4	mmHg	mmHg	NNS
cord-012902-efprpk72	143	5	.	.	.
cord-012902-efprpk72	144	1	Optimal	optimal	JJ
cord-012902-efprpk72	144	2	anti	anti	JJ
cord-012902-efprpk72	144	3	-	-	JJ
cord-012902-efprpk72	144	4	hypertensive	hypertensive	JJ
cord-012902-efprpk72	144	5	medication	medication	NN
cord-012902-efprpk72	144	6	dosing	dosing	NN
cord-012902-efprpk72	144	7	was	be	VBD
cord-012902-efprpk72	144	8	determined	determine	VBN
cord-012902-efprpk72	144	9	by	by	IN
cord-012902-efprpk72	144	10	benchmarking	benchmarke	VBG
cord-012902-efprpk72	144	11	prescribed	prescribe	VBN
cord-012902-efprpk72	144	12	doses	dose	NNS
cord-012902-efprpk72	144	13	with	with	IN
cord-012902-efprpk72	144	14	the	the	DT
cord-012902-efprpk72	144	15	World	World	NNP
cord-012902-efprpk72	144	16	Health	Health	NNP
cord-012902-efprpk72	144	17	Organisation	Organisation	NNP
cord-012902-efprpk72	144	18	-	-	HYPH
cord-012902-efprpk72	144	19	Defined	define	VBN
cord-012902-efprpk72	144	20	Daily	Daily	NNP
cord-012902-efprpk72	144	21	Dosing	Dosing	NNP
cord-012902-efprpk72	144	22	(	(	-LRB-
cord-012902-efprpk72	144	23	WHO	who	WP
cord-012902-efprpk72	144	24	-	-	HYPH
cord-012902-efprpk72	144	25	DDD	DDD	NNP
cord-012902-efprpk72	144	26	)	)	-RRB-
cord-012902-efprpk72	144	27	recommendations	recommendation	NNS
cord-012902-efprpk72	144	28	.	.	.
cord-012902-efprpk72	145	1	Results	result	NNS
cord-012902-efprpk72	145	2	:	:	:
cord-012902-efprpk72	145	3	We	-PRON-	PRP
cord-012902-efprpk72	145	4	identified	identify	VBD
cord-012902-efprpk72	145	5	328	328	CD
cord-012902-efprpk72	145	6	patients	patient	NNS
cord-012902-efprpk72	145	7	.	.	.
cord-012902-efprpk72	146	1	Blood	blood	NN
cord-012902-efprpk72	146	2	pressure	pressure	NN
cord-012902-efprpk72	146	3	was	be	VBD
cord-012902-efprpk72	146	4	controlled	control	VBN
cord-012902-efprpk72	146	5	in	in	IN
cord-012902-efprpk72	146	6	almost	almost	RB
cord-012902-efprpk72	146	7	two	two	CD
cord-012902-efprpk72	146	8	thirds	third	NNS
cord-012902-efprpk72	146	9	of	of	IN
cord-012902-efprpk72	146	10	patients	patient	NNS
cord-012902-efprpk72	146	11	when	when	WRB
cord-012902-efprpk72	146	12	measured	measure	VBN
cord-012902-efprpk72	146	13	against	against	IN
cord-012902-efprpk72	146	14	the	the	DT
cord-012902-efprpk72	146	15	ESH	ESH	NNP
cord-012902-efprpk72	146	16	guidelines	guideline	NNS
cord-012902-efprpk72	146	17	(	(	-LRB-
cord-012902-efprpk72	146	18	63.2	63.2	CD
cord-012902-efprpk72	146	19	%	%	NN
cord-012902-efprpk72	146	20	,	,	,
cord-012902-efprpk72	146	21	n	n	NN
cord-012902-efprpk72	146	22	=	=	SYM
cord-012902-efprpk72	146	23	207	207	CD
cord-012902-efprpk72	146	24	)	)	-RRB-
cord-012902-efprpk72	146	25	,	,	,
cord-012902-efprpk72	146	26	but	but	CC
cord-012902-efprpk72	146	27	in	in	IN
cord-012902-efprpk72	146	28	only	only	RB
cord-012902-efprpk72	146	29	one	one	CD
cord-012902-efprpk72	146	30	third	third	NN
cord-012902-efprpk72	146	31	of	of	IN
cord-012902-efprpk72	146	32	patients	patient	NNS
cord-012902-efprpk72	146	33	according	accord	VBG
cord-012902-efprpk72	146	34	to	to	IN
cord-012902-efprpk72	146	35	the	the	DT
cord-012902-efprpk72	146	36	AHA	AHA	NNP
cord-012902-efprpk72	146	37	guidelines	guideline	NNS
cord-012902-efprpk72	146	38	(	(	-LRB-
cord-012902-efprpk72	146	39	28.4	28.4	CD
cord-012902-efprpk72	146	40	%	%	NN
cord-012902-efprpk72	146	41	,	,	,
cord-012902-efprpk72	146	42	n	n	NN
cord-012902-efprpk72	146	43	=	=	SYM
cord-012902-efprpk72	146	44	93	93	CD
cord-012902-efprpk72	146	45	)	)	-RRB-
cord-012902-efprpk72	146	46	.	.	.
cord-012902-efprpk72	147	1	Of	of	IN
cord-012902-efprpk72	147	2	those	those	DT
cord-012902-efprpk72	147	3	with	with	IN
cord-012902-efprpk72	147	4	BP	BP	NNP
cord-012902-efprpk72	147	5	≥	≥	CD
cord-012902-efprpk72	147	6	140/90	140/90	NNP
cord-012902-efprpk72	147	7	(	(	-LRB-
cord-012902-efprpk72	147	8	n	n	NN
cord-012902-efprpk72	147	9	=	=	SYM
cord-012902-efprpk72	147	10	116	116	CD
cord-012902-efprpk72	147	11	)	)	-RRB-
cord-012902-efprpk72	147	12	,	,	,
cord-012902-efprpk72	147	13	22	22	CD
cord-012902-efprpk72	147	14	patients	patient	NNS
cord-012902-efprpk72	147	15	were	be	VBD
cord-012902-efprpk72	147	16	not	not	RB
cord-012902-efprpk72	147	17	prescribed	prescribe	VBN
cord-012902-efprpk72	147	18	anti	anti	JJ
cord-012902-efprpk72	147	19	-	-	JJ
cord-012902-efprpk72	147	20	hypertensive	hypertensive	JJ
cord-012902-efprpk72	147	21	drugs	drug	NNS
cord-012902-efprpk72	147	22	,	,	,
cord-012902-efprpk72	147	23	and	and	CC
cord-012902-efprpk72	147	24	31	31	CD
cord-012902-efprpk72	147	25	were	be	VBD
cord-012902-efprpk72	147	26	prescribed	prescribe	VBN
cord-012902-efprpk72	147	27	a	a	DT
cord-012902-efprpk72	147	28	single	single	JJ
cord-012902-efprpk72	147	29	agent	agent	NN
cord-012902-efprpk72	147	30	only	only	RB
cord-012902-efprpk72	147	31	.	.	.
cord-012902-efprpk72	148	1	Interestingly	interestingly	RB
cord-012902-efprpk72	148	2	,	,	,
cord-012902-efprpk72	148	3	38	38	CD
cord-012902-efprpk72	148	4	%	%	NN
cord-012902-efprpk72	148	5	of	of	IN
cord-012902-efprpk72	148	6	all	all	DT
cord-012902-efprpk72	148	7	patients	patient	NNS
cord-012902-efprpk72	148	8	were	be	VBD
cord-012902-efprpk72	148	9	inadequately	inadequately	RB
cord-012902-efprpk72	148	10	dosed	dose	VBN
cord-012902-efprpk72	148	11	when	when	WRB
cord-012902-efprpk72	148	12	compared	compare	VBN
cord-012902-efprpk72	148	13	with	with	IN
cord-012902-efprpk72	148	14	the	the	DT
cord-012902-efprpk72	148	15	WHO	WHO	NNP
cord-012902-efprpk72	148	16	-	-	HYPH
cord-012902-efprpk72	148	17	DDD	DDD	NNP
cord-012902-efprpk72	148	18	recommendations	recommendation	NNS
cord-012902-efprpk72	148	19	.	.	.
cord-012902-efprpk72	149	1	Conclusions	conclusion	NNS
cord-012902-efprpk72	149	2	:	:	:
cord-012902-efprpk72	150	1	At	at	IN
cord-012902-efprpk72	150	2	a	a	DT
cord-012902-efprpk72	150	3	minimum	minimum	NN
cord-012902-efprpk72	150	4	,	,	,
cord-012902-efprpk72	150	5	blood	blood	NN
cord-012902-efprpk72	150	6	pressure	pressure	NN
cord-012902-efprpk72	150	7	control	control	NN
cord-012902-efprpk72	150	8	appears	appear	VBZ
cord-012902-efprpk72	150	9	inadequate	inadequate	JJ
cord-012902-efprpk72	150	10	in	in	IN
cord-012902-efprpk72	150	11	at	at	RB
cord-012902-efprpk72	150	12	least	least	RBS
cord-012902-efprpk72	150	13	one	one	CD
cord-012902-efprpk72	150	14	third	third	NN
cord-012902-efprpk72	150	15	of	of	IN
cord-012902-efprpk72	150	16	patients	patient	NNS
cord-012902-efprpk72	150	17	with	with	IN
cord-012902-efprpk72	150	18	a	a	DT
cord-012902-efprpk72	150	19	previous	previous	JJ
cord-012902-efprpk72	150	20	stroke	stroke	NN
cord-012902-efprpk72	150	21	or	or	CC
cord-012902-efprpk72	150	22	TIA	TIA	NNP
cord-012902-efprpk72	150	23	,	,	,
cord-012902-efprpk72	150	24	and	and	CC
cord-012902-efprpk72	150	25	38	38	CD
cord-012902-efprpk72	150	26	%	%	NN
cord-012902-efprpk72	150	27	may	may	MD
cord-012902-efprpk72	150	28	respond	respond	VB
cord-012902-efprpk72	150	29	to	to	IN
cord-012902-efprpk72	150	30	antihypertensive	antihypertensive	JJ
cord-012902-efprpk72	150	31	dose	dose	NN
cord-012902-efprpk72	150	32	escalation	escalation	NN
cord-012902-efprpk72	150	33	.	.	.
cord-012902-efprpk72	151	1	Further	further	JJ
cord-012902-efprpk72	151	2	work	work	NN
cord-012902-efprpk72	151	3	is	be	VBZ
cord-012902-efprpk72	151	4	required	require	VBN
cord-012902-efprpk72	151	5	to	to	TO
cord-012902-efprpk72	151	6	see	see	VB
cord-012902-efprpk72	151	7	how	how	WRB
cord-012902-efprpk72	151	8	best	good	JJS
cord-012902-efprpk72	151	9	to	to	TO
cord-012902-efprpk72	151	10	manage	manage	VB
cord-012902-efprpk72	151	11	blood	blood	NN
cord-012902-efprpk72	151	12	pressure	pressure	NN
cord-012902-efprpk72	151	13	in	in	IN
cord-012902-efprpk72	151	14	patients	patient	NNS
cord-012902-efprpk72	151	15	with	with	IN
cord-012902-efprpk72	151	16	a	a	DT
cord-012902-efprpk72	151	17	previous	previous	JJ
cord-012902-efprpk72	151	18	stroke	stroke	NN
cord-012902-efprpk72	151	19	or	or	CC
cord-012902-efprpk72	151	20	TIA	TIA	NNP
cord-012902-efprpk72	151	21	in	in	IN
cord-012902-efprpk72	151	22	Primary	Primary	NNP
cord-012902-efprpk72	151	23	Care	Care	NNP
cord-012902-efprpk72	151	24	.	.	.
cord-012902-efprpk72	152	1	O-09	O-09	NNP
cord-012902-efprpk72	152	2	A	a	DT
cord-012902-efprpk72	152	3	novel	novel	JJ
cord-012902-efprpk72	152	4	method	method	NN
cord-012902-efprpk72	152	5	for	for	IN
cord-012902-efprpk72	152	6	prescription	prescription	NN
cord-012902-efprpk72	152	7	of	of	IN
cord-012902-efprpk72	152	8	safe	safe	JJ
cord-012902-efprpk72	152	9	and	and	CC
cord-012902-efprpk72	152	10	effective	effective	JJ
cord-012902-efprpk72	152	11	cardiovascular	cardiovascular	JJ
cord-012902-efprpk72	152	12	exercise	exercise	NN
cord-012902-efprpk72	152	13	for	for	IN
cord-012902-efprpk72	152	14	hypertensive	hypertensive	JJ
cord-012902-efprpk72	152	15	patients	patient	NNS
cord-012902-efprpk72	152	16	Sam	Sam	NNP
cord-012902-efprpk72	152	17	Olden	Olden	NNP
cord-012902-efprpk72	152	18	1	1	CD
cord-012902-efprpk72	153	1	*	*	NFP
cord-012902-efprpk72	153	2	,	,	,
cord-012902-efprpk72	153	3	Ivor	Ivor	NNP
cord-012902-efprpk72	153	4	Cradock	Cradock	NNP
cord-012902-efprpk72	154	1	1	1	CD
cord-012902-efprpk72	154	2	1	1	CD
cord-012902-efprpk72	154	3	Clinical	Clinical	NNP
cord-012902-efprpk72	154	4	Prevention	Prevention	NNP
cord-012902-efprpk72	154	5	and	and	CC
cord-012902-efprpk72	154	6	Rehabilitation	Rehabilitation	NNP
cord-012902-efprpk72	154	7	,	,	,
cord-012902-efprpk72	154	8	London	London	NNP
cord-012902-efprpk72	154	9	,	,	,
cord-012902-efprpk72	155	1	UK	UK	NNP
cord-012902-efprpk72	155	2	Introduction	introduction	NN
cord-012902-efprpk72	155	3	:	:	:
cord-012902-efprpk72	156	1	NICE	nice	JJ
cord-012902-efprpk72	156	2	[	[	-LRB-
cord-012902-efprpk72	156	3	1	1	CD
cord-012902-efprpk72	156	4	]	]	-RRB-
cord-012902-efprpk72	156	5	guidelines	guideline	NNS
cord-012902-efprpk72	156	6	recommend	recommend	VBP
cord-012902-efprpk72	156	7	cardiovascular	cardiovascular	JJ
cord-012902-efprpk72	156	8	exercise	exercise	NN
cord-012902-efprpk72	156	9	for	for	IN
cord-012902-efprpk72	156	10	cardiovascular	cardiovascular	JJ
cord-012902-efprpk72	156	11	risk	risk	NN
cord-012902-efprpk72	156	12	management	management	NN
cord-012902-efprpk72	156	13	.	.	.
cord-012902-efprpk72	157	1	There	there	EX
cord-012902-efprpk72	157	2	is	be	VBZ
cord-012902-efprpk72	157	3	little	little	JJ
cord-012902-efprpk72	157	4	guidance	guidance	NN
cord-012902-efprpk72	157	5	on	on	IN
cord-012902-efprpk72	157	6	how	how	WRB
cord-012902-efprpk72	157	7	to	to	TO
cord-012902-efprpk72	157	8	identify	identify	VB
cord-012902-efprpk72	157	9	appropriate	appropriate	JJ
cord-012902-efprpk72	157	10	cardiovascular	cardiovascular	JJ
cord-012902-efprpk72	157	11	exercise	exercise	NN
cord-012902-efprpk72	157	12	prescription	prescription	NN
cord-012902-efprpk72	157	13	and	and	CC
cord-012902-efprpk72	157	14	monitor	monitor	VB
cord-012902-efprpk72	157	15	adherence	adherence	NN
cord-012902-efprpk72	157	16	to	to	IN
cord-012902-efprpk72	157	17	the	the	DT
cord-012902-efprpk72	157	18	prescribed	prescribed	JJ
cord-012902-efprpk72	157	19	exercise	exercise	NN
cord-012902-efprpk72	157	20	.	.	.
cord-012902-efprpk72	158	1	This	this	DT
cord-012902-efprpk72	158	2	study	study	NN
cord-012902-efprpk72	158	3	investigates	investigate	VBZ
cord-012902-efprpk72	158	4	the	the	DT
cord-012902-efprpk72	158	5	feasibility	feasibility	NN
cord-012902-efprpk72	158	6	of	of	IN
cord-012902-efprpk72	158	7	CPET	CPET	NNS
cord-012902-efprpk72	158	8	for	for	IN
cord-012902-efprpk72	158	9	safe	safe	JJ
cord-012902-efprpk72	158	10	and	and	CC
cord-012902-efprpk72	158	11	effective	effective	JJ
cord-012902-efprpk72	158	12	cardiovascular	cardiovascular	JJ
cord-012902-efprpk72	158	13	exercise	exercise	NN
cord-012902-efprpk72	158	14	prescription	prescription	NN
cord-012902-efprpk72	158	15	in	in	IN
cord-012902-efprpk72	158	16	hypertensive	hypertensive	JJ
cord-012902-efprpk72	158	17	patients	patient	NNS
cord-012902-efprpk72	158	18	Methods	method	NNS
cord-012902-efprpk72	158	19	:	:	:
cord-012902-efprpk72	158	20	14	14	CD
cord-012902-efprpk72	158	21	subjects	subject	NNS
cord-012902-efprpk72	158	22	(	(	-LRB-
cord-012902-efprpk72	158	23	10	10	CD
cord-012902-efprpk72	158	24	Male	Male	NNP
cord-012902-efprpk72	158	25	,	,	,
cord-012902-efprpk72	158	26	4	4	CD
cord-012902-efprpk72	158	27	Female	female	JJ
cord-012902-efprpk72	158	28	;	;	:
cord-012902-efprpk72	158	29	aged	aged	JJ
cord-012902-efprpk72	158	30	61.8	61.8	CD
cord-012902-efprpk72	158	31	±	±	CD
cord-012902-efprpk72	158	32	10.8	10.8	CD
cord-012902-efprpk72	158	33	years	year	NNS
cord-012902-efprpk72	158	34	)	)	-RRB-
cord-012902-efprpk72	158	35	with	with	IN
cord-012902-efprpk72	158	36	hypertension	hypertension	NN
cord-012902-efprpk72	158	37	and	and	CC
cord-012902-efprpk72	158	38	undergoing	undergo	VBG
cord-012902-efprpk72	158	39	medical	medical	JJ
cord-012902-efprpk72	158	40	therapy	therapy	NN
cord-012902-efprpk72	158	41	were	be	VBD
cord-012902-efprpk72	158	42	recruited	recruit	VBN
cord-012902-efprpk72	158	43	to	to	IN
cord-012902-efprpk72	158	44	the	the	DT
cord-012902-efprpk72	158	45	study	study	NN
cord-012902-efprpk72	158	46	.	.	.
cord-012902-efprpk72	159	1	Each	each	DT
cord-012902-efprpk72	159	2	subject	subject	NN
cord-012902-efprpk72	159	3	underwent	undergo	VBD
cord-012902-efprpk72	159	4	a	a	DT
cord-012902-efprpk72	159	5	CPET	CPET	NNP
cord-012902-efprpk72	159	6	to	to	IN
cord-012902-efprpk72	159	7	80	80	CD
cord-012902-efprpk72	159	8	%	%	NN
cord-012902-efprpk72	159	9	heart	heart	NN
cord-012902-efprpk72	159	10	rate	rate	NN
cord-012902-efprpk72	159	11	reserve	reserve	NN
cord-012902-efprpk72	159	12	pre	pre	JJ
cord-012902-efprpk72	159	13	-	-	JJ
cord-012902-efprpk72	159	14	and	and	CC
cord-012902-efprpk72	159	15	post	post	JJ
cord-012902-efprpk72	159	16	-	-	NN
cord-012902-efprpk72	159	17	intervention	intervention	NN
cord-012902-efprpk72	159	18	as	as	IN
cord-012902-efprpk72	159	19	part	part	NN
cord-012902-efprpk72	159	20	of	of	IN
cord-012902-efprpk72	159	21	a	a	DT
cord-012902-efprpk72	159	22	wider	wide	JJR
cord-012902-efprpk72	159	23	health	health	NN
cord-012902-efprpk72	159	24	assessment	assessment	NN
cord-012902-efprpk72	159	25	process	process	NN
cord-012902-efprpk72	159	26	.	.	.
cord-012902-efprpk72	160	1	Each	each	DT
cord-012902-efprpk72	160	2	subject	subject	NN
cord-012902-efprpk72	160	3	was	be	VBD
cord-012902-efprpk72	160	4	prescribed	prescribe	VBN
cord-012902-efprpk72	160	5	a	a	DT
cord-012902-efprpk72	160	6	steady	steady	JJ
cord-012902-efprpk72	160	7	state	state	NN
cord-012902-efprpk72	160	8	heart	heart	NN
cord-012902-efprpk72	160	9	rate	rate	NN
cord-012902-efprpk72	160	10	zone	zone	NN
cord-012902-efprpk72	160	11	within	within	IN
cord-012902-efprpk72	160	12	the	the	DT
cord-012902-efprpk72	160	13	heavy	heavy	JJ
cord-012902-efprpk72	160	14	intensity	intensity	NN
cord-012902-efprpk72	160	15	exercise	exercise	NN
cord-012902-efprpk72	160	16	domain	domain	NN
cord-012902-efprpk72	160	17	(	(	-LRB-
cord-012902-efprpk72	160	18	between	between	IN
cord-012902-efprpk72	160	19	first	first	JJ
cord-012902-efprpk72	160	20	and	and	CC
cord-012902-efprpk72	160	21	second	second	JJ
cord-012902-efprpk72	160	22	ventilatory	ventilatory	JJ
cord-012902-efprpk72	160	23	thresholds	threshold	NNS
cord-012902-efprpk72	160	24	[	[	-LRB-
cord-012902-efprpk72	160	25	VT1	vt1	NN
cord-012902-efprpk72	160	26	and	and	CC
cord-012902-efprpk72	160	27	VT2	VT2	NNP
cord-012902-efprpk72	160	28	]	]	-RRB-
cord-012902-efprpk72	160	29	with	with	IN
cord-012902-efprpk72	160	30	the	the	DT
cord-012902-efprpk72	160	31	RER	RER	NNP
cord-012902-efprpk72	160	32	below	below	IN
cord-012902-efprpk72	160	33	1.00	1.00	CD
cord-012902-efprpk72	160	34	)	)	-RRB-
cord-012902-efprpk72	160	35	.	.	.
cord-012902-efprpk72	161	1	Subjects	subject	NNS
cord-012902-efprpk72	161	2	were	be	VBD
cord-012902-efprpk72	161	3	instructed	instruct	VBN
cord-012902-efprpk72	161	4	to	to	TO
cord-012902-efprpk72	161	5	perform	perform	VB
cord-012902-efprpk72	161	6	2	2	CD
cord-012902-efprpk72	161	7	sessions	session	NNS
cord-012902-efprpk72	161	8	per	per	IN
cord-012902-efprpk72	161	9	week	week	NN
cord-012902-efprpk72	161	10	over	over	IN
cord-012902-efprpk72	161	11	12-weeks	12-weeks	CD
cord-012902-efprpk72	161	12	.	.	.
cord-012902-efprpk72	162	1	The	the	DT
cord-012902-efprpk72	162	2	sessions	session	NNS
cord-012902-efprpk72	162	3	were	be	VBD
cord-012902-efprpk72	162	4	prescribed	prescribe	VBN
cord-012902-efprpk72	162	5	at	at	IN
cord-012902-efprpk72	162	6	45	45	CD
cord-012902-efprpk72	162	7	min	min	NN
cord-012902-efprpk72	162	8	length	length	NN
cord-012902-efprpk72	162	9	,	,	,
cord-012902-efprpk72	162	10	including	include	VBG
cord-012902-efprpk72	162	11	a	a	DT
cord-012902-efprpk72	162	12	10-min	10-min	CD
cord-012902-efprpk72	162	13	warm	warm	NN
cord-012902-efprpk72	162	14	up	up	RP
cord-012902-efprpk72	162	15	and	and	CC
cord-012902-efprpk72	162	16	cool	cool	VB
cord-012902-efprpk72	162	17	down	down	RP
cord-012902-efprpk72	162	18	.	.	.
cord-012902-efprpk72	163	1	Cardiovascular	cardiovascular	JJ
cord-012902-efprpk72	163	2	sessions	session	NNS
cord-012902-efprpk72	163	3	were	be	VBD
cord-012902-efprpk72	163	4	monitored	monitor	VBN
cord-012902-efprpk72	163	5	remotely	remotely	RB
cord-012902-efprpk72	163	6	via	via	IN
cord-012902-efprpk72	163	7	heart	heart	NN
cord-012902-efprpk72	163	8	rate	rate	NN
cord-012902-efprpk72	163	9	monitoring	monitoring	NN
cord-012902-efprpk72	163	10	devices	device	NNS
cord-012902-efprpk72	163	11	and	and	CC
cord-012902-efprpk72	163	12	internet	internet	NN
cord-012902-efprpk72	163	13	software	software	NN
cord-012902-efprpk72	163	14	.	.	.
cord-012902-efprpk72	164	1	Results	result	NNS
cord-012902-efprpk72	164	2	:	:	:
cord-012902-efprpk72	165	1	There	there	EX
cord-012902-efprpk72	165	2	were	be	VBD
cord-012902-efprpk72	165	3	no	no	DT
cord-012902-efprpk72	165	4	adverse	adverse	JJ
cord-012902-efprpk72	165	5	events	event	NNS
cord-012902-efprpk72	165	6	during	during	IN
cord-012902-efprpk72	165	7	the	the	DT
cord-012902-efprpk72	165	8	study	study	NN
cord-012902-efprpk72	165	9	and	and	CC
cord-012902-efprpk72	165	10	no	no	DT
cord-012902-efprpk72	165	11	subjects	subject	NNS
cord-012902-efprpk72	165	12	withdrew	withdraw	VBD
cord-012902-efprpk72	165	13	from	from	IN
cord-012902-efprpk72	165	14	the	the	DT
cord-012902-efprpk72	165	15	intervention	intervention	NN
cord-012902-efprpk72	165	16	.	.	.
cord-012902-efprpk72	166	1	The	the	DT
cord-012902-efprpk72	166	2	average	average	JJ
cord-012902-efprpk72	166	3	adherence	adherence	NN
cord-012902-efprpk72	166	4	to	to	IN
cord-012902-efprpk72	166	5	cardiovascular	cardiovascular	JJ
cord-012902-efprpk72	166	6	sessions	session	NNS
cord-012902-efprpk72	166	7	was	be	VBD
cord-012902-efprpk72	166	8	1.9±0.8/	1.9±0.8/	CD
cord-012902-efprpk72	166	9	week	week	NN
cord-012902-efprpk72	166	10	.	.	.
cord-012902-efprpk72	167	1	Systolic	systolic	JJ
cord-012902-efprpk72	167	2	blood	blood	NN
cord-012902-efprpk72	167	3	pressure	pressure	NN
cord-012902-efprpk72	167	4	reduced	reduce	VBN
cord-012902-efprpk72	167	5	by	by	IN
cord-012902-efprpk72	167	6	7.9	7.9	CD
cord-012902-efprpk72	167	7	mmHg	mmHg	NNS
cord-012902-efprpk72	167	8	(	(	-LRB-
cord-012902-efprpk72	167	9	135.0	135.0	CD
cord-012902-efprpk72	167	10	±	±	CD
cord-012902-efprpk72	167	11	13.7	13.7	CD
cord-012902-efprpk72	167	12	to	to	IN
cord-012902-efprpk72	167	13	127.1	127.1	CD
cord-012902-efprpk72	167	14	±	±	CD
cord-012902-efprpk72	167	15	17.7	17.7	CD
cord-012902-efprpk72	167	16	mmHg	mmHg	NNS
cord-012902-efprpk72	167	17	;	;	:
cord-012902-efprpk72	167	18	p	p	NN
cord-012902-efprpk72	167	19	<	<	XX
cord-012902-efprpk72	167	20	0.01	0.01	CD
cord-012902-efprpk72	167	21	)	)	-RRB-
cord-012902-efprpk72	167	22	after	after	IN
cord-012902-efprpk72	167	23	12-weeks	12-weeks	CD
cord-012902-efprpk72	167	24	.	.	.
cord-012902-efprpk72	168	1	Predicted	predict	VBN
cord-012902-efprpk72	168	2	maximal	maximal	JJ
cord-012902-efprpk72	168	3	oxygen	oxygen	NN
cord-012902-efprpk72	168	4	uptake	uptake	NN
cord-012902-efprpk72	168	5	did	do	VBD
cord-012902-efprpk72	168	6	not	not	RB
cord-012902-efprpk72	168	7	increase	increase	VB
cord-012902-efprpk72	168	8	significantly	significantly	RB
cord-012902-efprpk72	168	9	after	after	IN
cord-012902-efprpk72	168	10	12	12	CD
cord-012902-efprpk72	168	11	weeks	week	NNS
cord-012902-efprpk72	168	12	.	.	.
cord-012902-efprpk72	169	1	Body	body	NN
cord-012902-efprpk72	169	2	mass	mass	NN
cord-012902-efprpk72	169	3	and	and	CC
cord-012902-efprpk72	169	4	body	body	NN
cord-012902-efprpk72	169	5	fat	fat	NN
cord-012902-efprpk72	169	6	percentage	percentage	NN
cord-012902-efprpk72	169	7	remained	remain	VBD
cord-012902-efprpk72	169	8	stable	stable	JJ
cord-012902-efprpk72	169	9	post	post	NN
cord-012902-efprpk72	169	10	-	-	NN
cord-012902-efprpk72	169	11	intervention	intervention	NN
cord-012902-efprpk72	169	12	.	.	.
cord-012902-efprpk72	170	1	Conclusions	conclusion	NNS
cord-012902-efprpk72	170	2	:	:	:
cord-012902-efprpk72	171	1	The	the	DT
cord-012902-efprpk72	171	2	current	current	JJ
cord-012902-efprpk72	171	3	study	study	NN
cord-012902-efprpk72	171	4	shows	show	VBZ
cord-012902-efprpk72	171	5	a	a	DT
cord-012902-efprpk72	171	6	novel	novel	NN
cord-012902-efprpk72	171	7	,	,	,
cord-012902-efprpk72	171	8	safe	safe	JJ
cord-012902-efprpk72	171	9	and	and	CC
cord-012902-efprpk72	171	10	effective	effective	JJ
cord-012902-efprpk72	171	11	method	method	NN
cord-012902-efprpk72	171	12	of	of	IN
cord-012902-efprpk72	171	13	accurate	accurate	JJ
cord-012902-efprpk72	171	14	cardiovascular	cardiovascular	JJ
cord-012902-efprpk72	171	15	prescription	prescription	NN
cord-012902-efprpk72	171	16	and	and	CC
cord-012902-efprpk72	171	17	monitoring	monitoring	NN
cord-012902-efprpk72	171	18	.	.	.
cord-012902-efprpk72	172	1	Since	since	IN
cord-012902-efprpk72	172	2	many	many	JJ
cord-012902-efprpk72	172	3	hypertensive	hypertensive	JJ
cord-012902-efprpk72	172	4	individuals	individual	NNS
cord-012902-efprpk72	172	5	undergoing	undergo	VBG
cord-012902-efprpk72	172	6	functional	functional	JJ
cord-012902-efprpk72	172	7	stress	stress	NN
cord-012902-efprpk72	172	8	tests	test	NNS
cord-012902-efprpk72	172	9	using	use	VBG
cord-012902-efprpk72	172	10	CPET	CPET	NNS
cord-012902-efprpk72	172	11	this	this	DT
cord-012902-efprpk72	172	12	warrants	warrant	NNS
cord-012902-efprpk72	172	13	further	further	JJ
cord-012902-efprpk72	172	14	research	research	NN
cord-012902-efprpk72	172	15	for	for	IN
cord-012902-efprpk72	172	16	the	the	DT
cord-012902-efprpk72	172	17	utilisation	utilisation	NN
cord-012902-efprpk72	172	18	of	of	IN
cord-012902-efprpk72	172	19	this	this	DT
cord-012902-efprpk72	172	20	data	datum	NNS
cord-012902-efprpk72	172	21	to	to	TO
cord-012902-efprpk72	172	22	be	be	VB
cord-012902-efprpk72	172	23	translated	translate	VBN
cord-012902-efprpk72	172	24	to	to	TO
cord-012902-efprpk72	172	25	exercise	exercise	VB
cord-012902-efprpk72	172	26	prescription	prescription	NN
cord-012902-efprpk72	172	27	advice	advice	NN
cord-012902-efprpk72	172	28	.	.	.
cord-012902-efprpk72	173	1	Future	future	JJ
cord-012902-efprpk72	173	2	research	research	NN
cord-012902-efprpk72	173	3	should	should	MD
cord-012902-efprpk72	173	4	also	also	RB
cord-012902-efprpk72	173	5	focus	focus	VB
cord-012902-efprpk72	173	6	on	on	IN
cord-012902-efprpk72	173	7	utilising	utilise	VBG
cord-012902-efprpk72	173	8	CPET	CPET	NNP
cord-012902-efprpk72	173	9	data	datum	NNS
cord-012902-efprpk72	173	10	to	to	TO
cord-012902-efprpk72	173	11	create	create	VB
cord-012902-efprpk72	173	12	an	an	DT
cord-012902-efprpk72	173	13	effective	effective	JJ
cord-012902-efprpk72	173	14	formula	formula	NN
cord-012902-efprpk72	173	15	for	for	IN
cord-012902-efprpk72	173	16	cardiovascular	cardiovascular	JJ
cord-012902-efprpk72	173	17	exercise	exercise	NN
cord-012902-efprpk72	173	18	prescription	prescription	NN
cord-012902-efprpk72	173	19	based	base	VBN
cord-012902-efprpk72	173	20	on	on	IN
cord-012902-efprpk72	173	21	heart	heart	NN
cord-012902-efprpk72	173	22	rate	rate	NN
cord-012902-efprpk72	173	23	data	datum	NNS
cord-012902-efprpk72	173	24	.	.	.
cord-012902-efprpk72	174	1	Longer	long	JJR
cord-012902-efprpk72	174	2	term	term	NN
cord-012902-efprpk72	174	3	studies	study	NNS
cord-012902-efprpk72	174	4	to	to	TO
cord-012902-efprpk72	174	5	investigate	investigate	VB
cord-012902-efprpk72	174	6	impact	impact	NN
cord-012902-efprpk72	174	7	on	on	IN
cord-012902-efprpk72	174	8	VO	VO	NNP
cord-012902-efprpk72	174	9	2	2	CD
cord-012902-efprpk72	174	10	max	max	NNP
cord-012902-efprpk72	174	11	should	should	MD
cord-012902-efprpk72	174	12	also	also	RB
cord-012902-efprpk72	174	13	be	be	VB
cord-012902-efprpk72	174	14	considered	consider	VBN
cord-012902-efprpk72	174	15	.	.	.
cord-012902-efprpk72	175	1	Disclosures	disclosure	NNS
cord-012902-efprpk72	175	2	:	:	:
cord-012902-efprpk72	175	3	None	none	NN
cord-012902-efprpk72	175	4	.	.	.
cord-012902-efprpk72	176	1	Introduction	introduction	NN
cord-012902-efprpk72	176	2	:	:	:
cord-012902-efprpk72	177	1	Adrenal	adrenal	JJ
cord-012902-efprpk72	177	2	venous	venous	JJ
cord-012902-efprpk72	177	3	sampling	sampling	NN
cord-012902-efprpk72	177	4	(	(	-LRB-
cord-012902-efprpk72	177	5	AVS	AVS	NNP
cord-012902-efprpk72	177	6	)	)	-RRB-
cord-012902-efprpk72	177	7	is	be	VBZ
cord-012902-efprpk72	177	8	considered	consider	VBN
cord-012902-efprpk72	177	9	the	the	DT
cord-012902-efprpk72	177	10	gold	gold	NN
cord-012902-efprpk72	177	11	standard	standard	NN
cord-012902-efprpk72	177	12	in	in	IN
cord-012902-efprpk72	177	13	determining	determine	VBG
cord-012902-efprpk72	177	14	unilaterality	unilaterality	NN
cord-012902-efprpk72	177	15	of	of	IN
cord-012902-efprpk72	177	16	primary	primary	JJ
cord-012902-efprpk72	177	17	aldosteronism	aldosteronism	NN
cord-012902-efprpk72	177	18	(	(	-LRB-
cord-012902-efprpk72	177	19	PA	PA	NNP
cord-012902-efprpk72	177	20	)	)	-RRB-
cord-012902-efprpk72	177	21	.	.	.
cord-012902-efprpk72	178	1	Failed	fail	VBN
cord-012902-efprpk72	178	2	right	right	JJ
cord-012902-efprpk72	178	3	adrenal	adrenal	JJ
cord-012902-efprpk72	178	4	vein	vein	NN
cord-012902-efprpk72	178	5	(	(	-LRB-
cord-012902-efprpk72	178	6	AV	av	NN
cord-012902-efprpk72	178	7	)	)	-RRB-
cord-012902-efprpk72	178	8	cannulation	cannulation	NN
cord-012902-efprpk72	178	9	poses	pose	VBZ
cord-012902-efprpk72	178	10	a	a	DT
cord-012902-efprpk72	178	11	technical	technical	JJ
cord-012902-efprpk72	178	12	hurdle	hurdle	NN
cord-012902-efprpk72	178	13	in	in	IN
cord-012902-efprpk72	178	14	a	a	DT
cord-012902-efprpk72	178	15	significant	significant	JJ
cord-012902-efprpk72	178	16	number	number	NN
cord-012902-efprpk72	178	17	of	of	IN
cord-012902-efprpk72	178	18	patients	patient	NNS
cord-012902-efprpk72	178	19	,	,	,
cord-012902-efprpk72	178	20	necessitating	necessitate	VBG
cord-012902-efprpk72	178	21	repeat	repeat	NN
cord-012902-efprpk72	178	22	AVS	AVS	NNP
cord-012902-efprpk72	178	23	.	.	.
cord-012902-efprpk72	179	1	Recently	recently	RB
cord-012902-efprpk72	179	2	,	,	,
cord-012902-efprpk72	179	3	studies	study	NNS
cord-012902-efprpk72	179	4	[	[	-LRB-
cord-012902-efprpk72	179	5	1	1	CD
cord-012902-efprpk72	179	6	,	,	,
cord-012902-efprpk72	179	7	2	2	CD
cord-012902-efprpk72	179	8	]	]	-RRB-
cord-012902-efprpk72	179	9	have	have	VBP
cord-012902-efprpk72	179	10	suggested	suggest	VBN
cord-012902-efprpk72	179	11	using	use	VBG
cord-012902-efprpk72	179	12	the	the	DT
cord-012902-efprpk72	179	13	ratio	ratio	NN
cord-012902-efprpk72	179	14	of	of	IN
cord-012902-efprpk72	179	15	aldosterone	aldosterone	NN
cord-012902-efprpk72	179	16	/	/	SYM
cord-012902-efprpk72	179	17	cortisol	cortisol	NN
cord-012902-efprpk72	179	18	(	(	-LRB-
cord-012902-efprpk72	179	19	A	A	NNP
cord-012902-efprpk72	179	20	/	/	SYM
cord-012902-efprpk72	179	21	C	c	NN
cord-012902-efprpk72	179	22	)	)	-RRB-
cord-012902-efprpk72	179	23	levels	level	NNS
cord-012902-efprpk72	179	24	between	between	IN
cord-012902-efprpk72	179	25	the	the	DT
cord-012902-efprpk72	179	26	left	left	JJ
cord-012902-efprpk72	179	27	AV	av	NN
cord-012902-efprpk72	179	28	and	and	CC
cord-012902-efprpk72	179	29	inferior	inferior	JJ
cord-012902-efprpk72	179	30	vena	vena	FW
cord-012902-efprpk72	179	31	cava	cava	FW
cord-012902-efprpk72	179	32	(	(	-LRB-
cord-012902-efprpk72	179	33	IVC	IVC	NNP
cord-012902-efprpk72	179	34	)	)	-RRB-
cord-012902-efprpk72	179	35	with	with	IN
cord-012902-efprpk72	179	36	100	100	CD
cord-012902-efprpk72	179	37	%	%	NN
cord-012902-efprpk72	179	38	positive	positive	JJ
cord-012902-efprpk72	179	39	predictive	predictive	JJ
cord-012902-efprpk72	179	40	value	value	NN
cord-012902-efprpk72	179	41	in	in	IN
cord-012902-efprpk72	179	42	AVS	AVS	NNP
cord-012902-efprpk72	179	43	under	under	IN
cord-012902-efprpk72	179	44	adrenocorticotrophic	adrenocorticotrophic	JJ
cord-012902-efprpk72	179	45	hormone	hormone	NN
cord-012902-efprpk72	179	46	(	(	-LRB-
cord-012902-efprpk72	179	47	ACTH	ACTH	NNP
cord-012902-efprpk72	179	48	)	)	-RRB-
cord-012902-efprpk72	179	49	stimulation	stimulation	NN
cord-012902-efprpk72	179	50	.	.	.
cord-012902-efprpk72	180	1	This	this	DT
cord-012902-efprpk72	180	2	study	study	NN
cord-012902-efprpk72	180	3	aims	aim	VBZ
cord-012902-efprpk72	180	4	to	to	TO
cord-012902-efprpk72	180	5	validate	validate	VB
cord-012902-efprpk72	180	6	those	those	DT
cord-012902-efprpk72	180	7	findings	finding	NNS
cord-012902-efprpk72	180	8	in	in	IN
cord-012902-efprpk72	180	9	unstimulated	unstimulated	JJ
cord-012902-efprpk72	180	10	AVS	AVS	NNP
cord-012902-efprpk72	180	11	.	.	.
cord-012902-efprpk72	181	1	Methods	method	NNS
cord-012902-efprpk72	181	2	:	:	:
cord-012902-efprpk72	181	3	A	a	DT
cord-012902-efprpk72	181	4	retrospective	retrospective	JJ
cord-012902-efprpk72	181	5	review	review	NN
cord-012902-efprpk72	181	6	was	be	VBD
cord-012902-efprpk72	181	7	performed	perform	VBN
cord-012902-efprpk72	181	8	of	of	IN
cord-012902-efprpk72	181	9	84	84	CD
cord-012902-efprpk72	181	10	patients	patient	NNS
cord-012902-efprpk72	181	11	(	(	-LRB-
cord-012902-efprpk72	181	12	51	51	CD
cord-012902-efprpk72	181	13	male	male	NN
cord-012902-efprpk72	181	14	,	,	,
cord-012902-efprpk72	181	15	33	33	CD
cord-012902-efprpk72	181	16	female	female	NN
cord-012902-efprpk72	181	17	,	,	,
cord-012902-efprpk72	181	18	mean	mean	VB
cord-012902-efprpk72	181	19	age	age	NN
cord-012902-efprpk72	181	20	49.2	49.2	CD
cord-012902-efprpk72	181	21	±	±	CD
cord-012902-efprpk72	181	22	10.1	10.1	CD
cord-012902-efprpk72	181	23	years	year	NNS
cord-012902-efprpk72	181	24	,	,	,
cord-012902-efprpk72	181	25	range	range	VBP
cord-012902-efprpk72	181	26	26	26	CD
cord-012902-efprpk72	181	27	-	-	SYM
cord-012902-efprpk72	181	28	73	73	CD
cord-012902-efprpk72	181	29	)	)	-RRB-
cord-012902-efprpk72	181	30	with	with	IN
cord-012902-efprpk72	181	31	PA	PA	NNP
cord-012902-efprpk72	181	32	who	who	WP
cord-012902-efprpk72	181	33	underwent	undergo	VBD
cord-012902-efprpk72	181	34	AVS	AVS	NNP
cord-012902-efprpk72	181	35	.	.	.
cord-012902-efprpk72	182	1	Datasets	dataset	NNS
cord-012902-efprpk72	182	2	with	with	IN
cord-012902-efprpk72	182	3	successful	successful	JJ
cord-012902-efprpk72	182	4	cannulation	cannulation	NN
cord-012902-efprpk72	182	5	,	,	,
cord-012902-efprpk72	182	6	with	with	IN
cord-012902-efprpk72	182	7	selectivity	selectivity	NN
cord-012902-efprpk72	182	8	index	index	NN
cord-012902-efprpk72	182	9	(	(	-LRB-
cord-012902-efprpk72	182	10	A	A	NNP
cord-012902-efprpk72	182	11	/	/	SYM
cord-012902-efprpk72	182	12	C	c	NN
cord-012902-efprpk72	182	13	ratio	ratio	NN
cord-012902-efprpk72	182	14	of	of	IN
cord-012902-efprpk72	182	15	Adrenal	adrenal	JJ
cord-012902-efprpk72	182	16	vein	vein	NN
cord-012902-efprpk72	182	17	/	/	,
cord-012902-efprpk72	182	18	IVC	IVC	NNP
cord-012902-efprpk72	182	19	)	)	-RRB-
cord-012902-efprpk72	182	20	of	of	IN
cord-012902-efprpk72	182	21	>	>	XX
cord-012902-efprpk72	182	22	1.1	1.1	CD
cord-012902-efprpk72	182	23	bilaterally	bilaterally	RB
cord-012902-efprpk72	182	24	,	,	,
cord-012902-efprpk72	182	25	were	be	VBD
cord-012902-efprpk72	182	26	analysed	analyse	VBN
cord-012902-efprpk72	182	27	N	n	NN
cord-012902-efprpk72	182	28	=	=	SYM
cord-012902-efprpk72	182	29	84	84	CD
cord-012902-efprpk72	182	30	.	.	.
cord-012902-efprpk72	183	1	Laterality	Laterality	NNP
cord-012902-efprpk72	183	2	was	be	VBD
cord-012902-efprpk72	183	3	defined	define	VBN
cord-012902-efprpk72	183	4	as	as	IN
cord-012902-efprpk72	183	5	a	a	DT
cord-012902-efprpk72	183	6	4:1	4:1	CD
cord-012902-efprpk72	183	7	ratio	ratio	NN
cord-012902-efprpk72	183	8	between	between	IN
cord-012902-efprpk72	183	9	side	side	NN
cord-012902-efprpk72	183	10	of	of	IN
cord-012902-efprpk72	183	11	adenoma	adenoma	NN
cord-012902-efprpk72	183	12	and	and	CC
cord-012902-efprpk72	183	13	the	the	DT
cord-012902-efprpk72	183	14	non	non	JJ
cord-012902-efprpk72	183	15	-	-	JJ
cord-012902-efprpk72	183	16	adenoma	adenoma	JJ
cord-012902-efprpk72	183	17	side	side	NN
cord-012902-efprpk72	183	18	.	.	.
cord-012902-efprpk72	184	1	AVS	AVS	NNP
cord-012902-efprpk72	184	2	results	result	NNS
cord-012902-efprpk72	184	3	were	be	VBD
cord-012902-efprpk72	184	4	compared	compare	VBN
cord-012902-efprpk72	184	5	to	to	IN
cord-012902-efprpk72	184	6	left	leave	VBN
cord-012902-efprpk72	184	7	AV	AV	NNP
cord-012902-efprpk72	184	8	/	/	SYM
cord-012902-efprpk72	184	9	IVC	IVC	NNP
cord-012902-efprpk72	184	10	ratios	ratio	NNS
cord-012902-efprpk72	184	11	utilising	utilise	VBG
cord-012902-efprpk72	184	12	published	publish	VBN
cord-012902-efprpk72	184	13	criteria	criterion	NNS
cord-012902-efprpk72	185	1	(	(	-LRB-
cord-012902-efprpk72	185	2	Left	left	NN
cord-012902-efprpk72	185	3	>	>	XX
cord-012902-efprpk72	185	4	5.5	5.5	CD
cord-012902-efprpk72	185	5	;	;	:
cord-012902-efprpk72	185	6	right	right	RB
cord-012902-efprpk72	185	7	<	<	XX
cord-012902-efprpk72	185	8	0.5	0.5	CD
cord-012902-efprpk72	185	9	)	)	-RRB-
cord-012902-efprpk72	185	10	.	.	.
cord-012902-efprpk72	186	1	Results	result	NNS
cord-012902-efprpk72	186	2	:	:	:
cord-012902-efprpk72	187	1	Inclusion	inclusion	NN
cord-012902-efprpk72	187	2	criteria	criterion	NNS
cord-012902-efprpk72	187	3	were	be	VBD
cord-012902-efprpk72	187	4	met	meet	VBN
cord-012902-efprpk72	187	5	in	in	IN
cord-012902-efprpk72	187	6	84	84	CD
cord-012902-efprpk72	187	7	AVS	AVS	NNP
cord-012902-efprpk72	187	8	datasets	dataset	NNS
cord-012902-efprpk72	187	9	(	(	-LRB-
cord-012902-efprpk72	187	10	left	leave	VBN
cord-012902-efprpk72	187	11	=	=	SYM
cord-012902-efprpk72	187	12	32	32	CD
cord-012902-efprpk72	187	13	,	,	,
cord-012902-efprpk72	187	14	right	right	JJ
cord-012902-efprpk72	187	15	=	=	SYM
cord-012902-efprpk72	187	16	24	24	CD
cord-012902-efprpk72	187	17	,	,	,
cord-012902-efprpk72	187	18	bilateral	bilateral	JJ
cord-012902-efprpk72	187	19	=	=	SYM
cord-012902-efprpk72	187	20	28	28	CD
cord-012902-efprpk72	187	21	)	)	-RRB-
cord-012902-efprpk72	187	22	.	.	.
cord-012902-efprpk72	188	1	Left	leave	VBN
cord-012902-efprpk72	188	2	AV	AV	NNP
cord-012902-efprpk72	188	3	/	/	SYM
cord-012902-efprpk72	188	4	IVC	IVC	NNP
cord-012902-efprpk72	188	5	index	index	NN
cord-012902-efprpk72	188	6	cut	cut	VBD
cord-012902-efprpk72	188	7	-	-	HYPH
cord-012902-efprpk72	188	8	off	off	NN
cord-012902-efprpk72	188	9	of	of	IN
cord-012902-efprpk72	188	10	>	>	XX
cord-012902-efprpk72	188	11	5.5	5.5	CD
cord-012902-efprpk72	188	12	would	would	MD
cord-012902-efprpk72	188	13	have	have	VB
cord-012902-efprpk72	188	14	led	lead	VBN
cord-012902-efprpk72	188	15	to	to	IN
cord-012902-efprpk72	188	16	1	1	CD
cord-012902-efprpk72	188	17	inappropriate	inappropriate	JJ
cord-012902-efprpk72	188	18	adrenalectomy	adrenalectomy	NN
cord-012902-efprpk72	188	19	and	and	CC
cord-012902-efprpk72	188	20	would	would	MD
cord-012902-efprpk72	188	21	have	have	VB
cord-012902-efprpk72	188	22	missed	miss	VBN
cord-012902-efprpk72	188	23	40.6	40.6	CD
cord-012902-efprpk72	188	24	%	%	NN
cord-012902-efprpk72	188	25	of	of	IN
cord-012902-efprpk72	188	26	left	left	JJ
cord-012902-efprpk72	188	27	-	-	HYPH
cord-012902-efprpk72	188	28	sided	sided	JJ
cord-012902-efprpk72	188	29	disease	disease	NN
cord-012902-efprpk72	188	30	.	.	.
cord-012902-efprpk72	189	1	Using	use	VBG
cord-012902-efprpk72	189	2	a	a	DT
cord-012902-efprpk72	189	3	higher	high	JJR
cord-012902-efprpk72	189	4	cut	cut	NN
cord-012902-efprpk72	189	5	-	-	HYPH
cord-012902-efprpk72	189	6	off	off	NN
cord-012902-efprpk72	189	7	of	of	IN
cord-012902-efprpk72	189	8	>	>	XX
cord-012902-efprpk72	189	9	6.0	6.0	CD
cord-012902-efprpk72	189	10	would	would	MD
cord-012902-efprpk72	189	11	have	have	VB
cord-012902-efprpk72	189	12	identified	identify	VBN
cord-012902-efprpk72	189	13	left	left	JJ
cord-012902-efprpk72	189	14	-	-	HYPH
cord-012902-efprpk72	189	15	sided	sided	JJ
cord-012902-efprpk72	189	16	lesions	lesion	NNS
cord-012902-efprpk72	189	17	with	with	IN
cord-012902-efprpk72	189	18	100	100	CD
cord-012902-efprpk72	189	19	%	%	NN
cord-012902-efprpk72	189	20	positive	positive	JJ
cord-012902-efprpk72	189	21	predictive	predictive	JJ
cord-012902-efprpk72	189	22	value	value	NN
cord-012902-efprpk72	189	23	(	(	-LRB-
cord-012902-efprpk72	189	24	PPV	PPV	NNP
cord-012902-efprpk72	189	25	)	)	-RRB-
cord-012902-efprpk72	189	26	,	,	,
cord-012902-efprpk72	189	27	however	however	RB
cord-012902-efprpk72	189	28	,	,	,
cord-012902-efprpk72	189	29	would	would	MD
cord-012902-efprpk72	189	30	have	have	VB
cord-012902-efprpk72	189	31	missed	miss	VBN
cord-012902-efprpk72	189	32	43.8	43.8	CD
cord-012902-efprpk72	189	33	%	%	NN
cord-012902-efprpk72	189	34	of	of	IN
cord-012902-efprpk72	189	35	left	left	JJ
cord-012902-efprpk72	189	36	-	-	HYPH
cord-012902-efprpk72	189	37	sided	sided	JJ
cord-012902-efprpk72	189	38	disease	disease	NN
cord-012902-efprpk72	189	39	.	.	.
cord-012902-efprpk72	190	1	Left	leave	VBN
cord-012902-efprpk72	190	2	AV	AV	NNP
cord-012902-efprpk72	190	3	/	/	SYM
cord-012902-efprpk72	190	4	IVC	IVC	NNP
cord-012902-efprpk72	190	5	index	index	NN
cord-012902-efprpk72	190	6	of	of	IN
cord-012902-efprpk72	190	7	<	<	NNP
cord-012902-efprpk72	190	8	0.5	0.5	CD
cord-012902-efprpk72	190	9	would	would	MD
cord-012902-efprpk72	190	10	have	have	VB
cord-012902-efprpk72	190	11	led	lead	VBN
cord-012902-efprpk72	190	12	to	to	IN
cord-012902-efprpk72	190	13	1	1	CD
cord-012902-efprpk72	190	14	inappropriate	inappropriate	JJ
cord-012902-efprpk72	190	15	adrenalectomy	adrenalectomy	NN
cord-012902-efprpk72	190	16	and	and	CC
cord-012902-efprpk72	190	17	missed	miss	VBD
cord-012902-efprpk72	190	18	37.5	37.5	CD
cord-012902-efprpk72	190	19	%	%	NN
cord-012902-efprpk72	190	20	of	of	IN
cord-012902-efprpk72	190	21	right	right	JJ
cord-012902-efprpk72	190	22	-	-	HYPH
cord-012902-efprpk72	190	23	sided	sided	JJ
cord-012902-efprpk72	190	24	disease	disease	NN
cord-012902-efprpk72	190	25	.	.	.
cord-012902-efprpk72	191	1	Using	use	VBG
cord-012902-efprpk72	191	2	a	a	DT
cord-012902-efprpk72	191	3	lower	low	JJR
cord-012902-efprpk72	191	4	cut	cut	NN
cord-012902-efprpk72	191	5	-	-	HYPH
cord-012902-efprpk72	191	6	off	off	NN
cord-012902-efprpk72	191	7	of	of	IN
cord-012902-efprpk72	191	8	<	<	NNP
cord-012902-efprpk72	191	9	0.4	0.4	CD
cord-012902-efprpk72	191	10	would	would	MD
cord-012902-efprpk72	191	11	have	have	VB
cord-012902-efprpk72	191	12	identified	identify	VBN
cord-012902-efprpk72	191	13	right	right	JJ
cord-012902-efprpk72	191	14	-	-	HYPH
cord-012902-efprpk72	191	15	sided	sided	JJ
cord-012902-efprpk72	191	16	disease	disease	NN
cord-012902-efprpk72	191	17	with	with	IN
cord-012902-efprpk72	191	18	100	100	CD
cord-012902-efprpk72	191	19	%	%	NN
cord-012902-efprpk72	191	20	PPV	PPV	NNP
cord-012902-efprpk72	191	21	,	,	,
cord-012902-efprpk72	191	22	however	however	RB
cord-012902-efprpk72	191	23	,	,	,
cord-012902-efprpk72	191	24	it	-PRON-	PRP
cord-012902-efprpk72	191	25	would	would	MD
cord-012902-efprpk72	191	26	miss	miss	VB
cord-012902-efprpk72	191	27	45.8	45.8	CD
cord-012902-efprpk72	191	28	%	%	NN
cord-012902-efprpk72	191	29	of	of	IN
cord-012902-efprpk72	191	30	right	right	JJ
cord-012902-efprpk72	191	31	-	-	HYPH
cord-012902-efprpk72	191	32	sided	sided	JJ
cord-012902-efprpk72	191	33	disease	disease	NN
cord-012902-efprpk72	191	34	.	.	.
cord-012902-efprpk72	192	1	Conclusions	conclusion	NNS
cord-012902-efprpk72	192	2	:	:	:
cord-012902-efprpk72	193	1	The	the	DT
cord-012902-efprpk72	193	2	suppression	suppression	NN
cord-012902-efprpk72	193	3	index	index	NN
cord-012902-efprpk72	193	4	(	(	-LRB-
cord-012902-efprpk72	193	5	left	leave	VBN
cord-012902-efprpk72	193	6	AV	AV	NNP
cord-012902-efprpk72	193	7	/	/	SYM
cord-012902-efprpk72	193	8	IVC	IVC	NNP
cord-012902-efprpk72	193	9	A	A	NNP
cord-012902-efprpk72	193	10	/	/	SYM
cord-012902-efprpk72	193	11	C	C	NNP
cord-012902-efprpk72	193	12	values	value	NNS
cord-012902-efprpk72	193	13	)	)	-RRB-
cord-012902-efprpk72	193	14	can	can	MD
cord-012902-efprpk72	193	15	be	be	VB
cord-012902-efprpk72	193	16	used	use	VBN
cord-012902-efprpk72	193	17	with	with	IN
cord-012902-efprpk72	193	18	some	some	DT
cord-012902-efprpk72	193	19	degree	degree	NN
cord-012902-efprpk72	193	20	of	of	IN
cord-012902-efprpk72	193	21	confidence	confidence	NN
cord-012902-efprpk72	193	22	in	in	IN
cord-012902-efprpk72	193	23	patients	patient	NNS
cord-012902-efprpk72	193	24	with	with	IN
cord-012902-efprpk72	193	25	failed	fail	VBN
cord-012902-efprpk72	193	26	RAV	RAV	NNP
cord-012902-efprpk72	193	27	cannulation	cannulation	NN
cord-012902-efprpk72	193	28	,	,	,
cord-012902-efprpk72	193	29	without	without	IN
cord-012902-efprpk72	193	30	necessarily	necessarily	RB
cord-012902-efprpk72	193	31	requiring	require	VBG
cord-012902-efprpk72	193	32	another	another	DT
cord-012902-efprpk72	193	33	invasive	invasive	JJ
cord-012902-efprpk72	193	34	procedure	procedure	NN
cord-012902-efprpk72	193	35	or	or	CC
cord-012902-efprpk72	193	36	ACTH	ACTH	NNP
cord-012902-efprpk72	193	37	use	use	NN
cord-012902-efprpk72	193	38	in	in	IN
cord-012902-efprpk72	193	39	centres	centre	NNS
cord-012902-efprpk72	193	40	who	who	WP
cord-012902-efprpk72	193	41	have	have	VBP
cord-012902-efprpk72	193	42	high	high	JJ
cord-012902-efprpk72	193	43	rates	rate	NNS
cord-012902-efprpk72	193	44	of	of	IN
cord-012902-efprpk72	193	45	success	success	NN
cord-012902-efprpk72	193	46	in	in	IN
cord-012902-efprpk72	193	47	the	the	DT
cord-012902-efprpk72	193	48	AVS	AVS	NNP
cord-012902-efprpk72	193	49	procedure	procedure	NN
cord-012902-efprpk72	193	50	.	.	.
cord-012902-efprpk72	194	1	Utility	utility	NN
cord-012902-efprpk72	194	2	and	and	CC
cord-012902-efprpk72	194	3	cut	cut	VB
cord-012902-efprpk72	194	4	-	-	HYPH
cord-012902-efprpk72	194	5	offs	off	NNS
cord-012902-efprpk72	194	6	need	need	NN
cord-012902-efprpk72	194	7	to	to	TO
cord-012902-efprpk72	194	8	be	be	VB
cord-012902-efprpk72	194	9	validated	validate	VBN
cord-012902-efprpk72	194	10	in	in	IN
cord-012902-efprpk72	194	11	larger	large	JJR
cord-012902-efprpk72	194	12	AVS	AVS	NNP
cord-012902-efprpk72	194	13	datasets	dataset	NNS
cord-012902-efprpk72	194	14	.	.	.
cord-012902-efprpk72	195	1	Disclosures	disclosure	NNS
cord-012902-efprpk72	195	2	:	:	:
cord-012902-efprpk72	195	3	None	none	NN
cord-012902-efprpk72	195	4	.	.	.
cord-012902-efprpk72	196	1	Introduction	introduction	NN
cord-012902-efprpk72	196	2	:	:	:
cord-012902-efprpk72	197	1	Hypertension	hypertension	NN
cord-012902-efprpk72	197	2	is	be	VBZ
cord-012902-efprpk72	197	3	a	a	DT
cord-012902-efprpk72	197	4	major	major	JJ
cord-012902-efprpk72	197	5	cardiovascular	cardiovascular	JJ
cord-012902-efprpk72	197	6	risk	risk	NN
cord-012902-efprpk72	197	7	factor	factor	NN
cord-012902-efprpk72	197	8	,	,	,
cord-012902-efprpk72	197	9	yet	yet	CC
cord-012902-efprpk72	197	10	many	many	JJ
cord-012902-efprpk72	197	11	patients	patient	NNS
cord-012902-efprpk72	197	12	remain	remain	VBP
cord-012902-efprpk72	197	13	undiagnosed	undiagnosed	JJ
cord-012902-efprpk72	197	14	.	.	.
cord-012902-efprpk72	198	1	The	the	DT
cord-012902-efprpk72	198	2	aim	aim	NN
cord-012902-efprpk72	198	3	of	of	IN
cord-012902-efprpk72	198	4	the	the	DT
cord-012902-efprpk72	198	5	May	May	NNP
cord-012902-efprpk72	198	6	Measurement	Measurement	NNP
cord-012902-efprpk72	198	7	Month	Month	NNP
cord-012902-efprpk72	198	8	(	(	-LRB-
cord-012902-efprpk72	198	9	MMM	MMM	NNP
cord-012902-efprpk72	198	10	)	)	-RRB-
cord-012902-efprpk72	198	11	screening	screening	NN
cord-012902-efprpk72	198	12	programme	programme	NN
cord-012902-efprpk72	198	13	was	be	VBD
cord-012902-efprpk72	198	14	to	to	TO
cord-012902-efprpk72	198	15	identify	identify	VB
cord-012902-efprpk72	198	16	individuals	individual	NNS
cord-012902-efprpk72	198	17	with	with	IN
cord-012902-efprpk72	198	18	undiagnosed	undiagnosed	JJ
cord-012902-efprpk72	198	19	hypertension	hypertension	NN
cord-012902-efprpk72	198	20	[	[	-LRB-
cord-012902-efprpk72	198	21	1	1	CD
cord-012902-efprpk72	198	22	]	]	-RRB-
cord-012902-efprpk72	198	23	.	.	.
cord-012902-efprpk72	199	1	Methods	method	NNS
cord-012902-efprpk72	199	2	:	:	:
cord-012902-efprpk72	199	3	Screening	screening	NN
cord-012902-efprpk72	199	4	centres	centre	NNS
cord-012902-efprpk72	199	5	set	set	VBN
cord-012902-efprpk72	199	6	up	up	RP
cord-012902-efprpk72	199	7	in	in	IN
cord-012902-efprpk72	199	8	various	various	JJ
cord-012902-efprpk72	199	9	hospitals	hospital	NNS
cord-012902-efprpk72	199	10	and	and	CC
cord-012902-efprpk72	199	11	public	public	JJ
cord-012902-efprpk72	199	12	areas	area	NNS
cord-012902-efprpk72	199	13	in	in	IN
cord-012902-efprpk72	199	14	Muscat	Muscat	NNP
cord-012902-efprpk72	199	15	,	,	,
cord-012902-efprpk72	199	16	Oman	Oman	NNP
cord-012902-efprpk72	199	17	during	during	IN
cord-012902-efprpk72	199	18	the	the	DT
cord-012902-efprpk72	199	19	months	month	NNS
cord-012902-efprpk72	199	20	of	of	IN
cord-012902-efprpk72	199	21	May	May	NNP
cord-012902-efprpk72	199	22	2017	2017	CD
cord-012902-efprpk72	199	23	and	and	CC
cord-012902-efprpk72	199	24	2018	2018	CD
cord-012902-efprpk72	199	25	according	accord	VBG
cord-012902-efprpk72	199	26	to	to	IN
cord-012902-efprpk72	199	27	the	the	DT
cord-012902-efprpk72	199	28	MMM	MMM	NNP
cord-012902-efprpk72	199	29	protocol	protocol	NN
cord-012902-efprpk72	199	30	with	with	IN
cord-012902-efprpk72	199	31	three	three	CD
cord-012902-efprpk72	199	32	BP	BP	NNP
cord-012902-efprpk72	199	33	readings	reading	NNS
cord-012902-efprpk72	199	34	taken	take	VBN
cord-012902-efprpk72	199	35	along	along	RP
cord-012902-efprpk72	199	36	with	with	IN
cord-012902-efprpk72	199	37	a	a	DT
cord-012902-efprpk72	199	38	questionnaire	questionnaire	NN
cord-012902-efprpk72	199	39	of	of	IN
cord-012902-efprpk72	199	40	demographic	demographic	JJ
cord-012902-efprpk72	199	41	,	,	,
cord-012902-efprpk72	199	42	lifestyle	lifestyle	NN
cord-012902-efprpk72	199	43	and	and	CC
cord-012902-efprpk72	199	44	other	other	JJ
cord-012902-efprpk72	199	45	risk	risk	NN
cord-012902-efprpk72	199	46	factors	factor	NNS
cord-012902-efprpk72	199	47	.	.	.
cord-012902-efprpk72	200	1	Hypertension	hypertension	NN
cord-012902-efprpk72	200	2	was	be	VBD
cord-012902-efprpk72	200	3	defined	define	VBN
cord-012902-efprpk72	200	4	according	accord	VBG
cord-012902-efprpk72	200	5	to	to	IN
cord-012902-efprpk72	200	6	the	the	DT
cord-012902-efprpk72	200	7	European	European	NNP
cord-012902-efprpk72	200	8	Society	Society	NNP
cord-012902-efprpk72	200	9	of	of	IN
cord-012902-efprpk72	200	10	Hypertension	Hypertension	NNP
cord-012902-efprpk72	200	11	2018	2018	CD
cord-012902-efprpk72	200	12	guidelines	guideline	NNS
cord-012902-efprpk72	200	13	[	[	-LRB-
cord-012902-efprpk72	200	14	2	2	CD
cord-012902-efprpk72	200	15	]	]	-RRB-
cord-012902-efprpk72	200	16	,	,	,
cord-012902-efprpk72	200	17	(	(	-LRB-
cord-012902-efprpk72	200	18	systolic	systolic	JJ
cord-012902-efprpk72	200	19	BP(SBP	bp(sbp	CD
cord-012902-efprpk72	200	20	)	)	-RRB-
cord-012902-efprpk72	201	1	≥	≥	CD
cord-012902-efprpk72	201	2	140	140	CD
cord-012902-efprpk72	201	3	mmHg	mmHg	NNS
cord-012902-efprpk72	201	4	and/or	and/or	CC
cord-012902-efprpk72	201	5	diastolic	diastolic	JJ
cord-012902-efprpk72	201	6	BP(DBP	BP(DBP	NNP
cord-012902-efprpk72	201	7	)	)	-RRB-
cord-012902-efprpk72	202	1	≥	≥	CD
cord-012902-efprpk72	202	2	90	90	CD
cord-012902-efprpk72	202	3	mmHg	mmHg	NNS
cord-012902-efprpk72	202	4	)	)	-RRB-
cord-012902-efprpk72	202	5	.	.	.
cord-012902-efprpk72	203	1	Results	result	NNS
cord-012902-efprpk72	203	2	:	:	:
cord-012902-efprpk72	204	1	A	a	DT
cord-012902-efprpk72	204	2	total	total	NN
cord-012902-efprpk72	204	3	of	of	IN
cord-012902-efprpk72	204	4	13,621	13,621	CD
cord-012902-efprpk72	204	5	individuals	individual	NNS
cord-012902-efprpk72	204	6	(	(	-LRB-
cord-012902-efprpk72	204	7	age	age	NN
cord-012902-efprpk72	204	8	40.8	40.8	CD
cord-012902-efprpk72	204	9	+	+	SYM
cord-012902-efprpk72	204	10	12.6	12.6	CD
cord-012902-efprpk72	204	11	years	year	NNS
cord-012902-efprpk72	204	12	,	,	,
cord-012902-efprpk72	204	13	30.1	30.1	CD
cord-012902-efprpk72	204	14	%	%	NN
cord-012902-efprpk72	204	15	male	male	NN
cord-012902-efprpk72	204	16	,	,	,
cord-012902-efprpk72	204	17	88.4	88.4	CD
cord-012902-efprpk72	204	18	%	%	NN
cord-012902-efprpk72	204	19	Arab	arab	JJ
cord-012902-efprpk72	204	20	ethnicity	ethnicity	NN
cord-012902-efprpk72	204	21	)	)	-RRB-
cord-012902-efprpk72	204	22	were	be	VBD
cord-012902-efprpk72	204	23	screened	screen	VBN
cord-012902-efprpk72	204	24	over	over	IN
cord-012902-efprpk72	204	25	the	the	DT
cord-012902-efprpk72	204	26	2-month	2-month	JJ
cord-012902-efprpk72	204	27	period	period	NN
cord-012902-efprpk72	204	28	.	.	.
cord-012902-efprpk72	205	1	The	the	DT
cord-012902-efprpk72	205	2	mean	mean	NN
cord-012902-efprpk72	205	3	of	of	IN
cord-012902-efprpk72	205	4	the	the	DT
cord-012902-efprpk72	205	5	first	first	JJ
cord-012902-efprpk72	205	6	BP	BP	NNP
cord-012902-efprpk72	205	7	was	be	VBD
cord-012902-efprpk72	205	8	132.1	132.1	CD
cord-012902-efprpk72	205	9	+	+	SYM
cord-012902-efprpk72	205	10	19.1/81.1	19.1/81.1	CD
cord-012902-efprpk72	205	11	+	+	SYM
cord-012902-efprpk72	205	12	12.2	12.2	CD
cord-012902-efprpk72	205	13	mmHg	mmHg	NNS
cord-012902-efprpk72	205	14	.	.	.
cord-012902-efprpk72	206	1	The	the	DT
cord-012902-efprpk72	206	2	average	average	NN
cord-012902-efprpk72	206	3	of	of	IN
cord-012902-efprpk72	206	4	the	the	DT
cord-012902-efprpk72	206	5	second	second	JJ
cord-012902-efprpk72	206	6	and	and	CC
cord-012902-efprpk72	206	7	third	third	JJ
cord-012902-efprpk72	206	8	readings	reading	NNS
cord-012902-efprpk72	206	9	,	,	,
cord-012902-efprpk72	206	10	where	where	WRB
cord-012902-efprpk72	206	11	available	available	JJ
cord-012902-efprpk72	206	12	(	(	-LRB-
cord-012902-efprpk72	206	13	n	n	NN
cord-012902-efprpk72	206	14	=	=	SYM
cord-012902-efprpk72	206	15	5934	5934	CD
cord-012902-efprpk72	206	16	,	,	,
cord-012902-efprpk72	206	17	age	age	NN
cord-012902-efprpk72	206	18	41.5	41.5	CD
cord-012902-efprpk72	206	19	+	+	SYM
cord-012902-efprpk72	206	20	14.3	14.3	CD
cord-012902-efprpk72	206	21	years	year	NNS
cord-012902-efprpk72	206	22	,	,	,
cord-012902-efprpk72	206	23	64.4	64.4	CD
cord-012902-efprpk72	206	24	%	%	NN
cord-012902-efprpk72	206	25	male	male	NN
cord-012902-efprpk72	206	26	)	)	-RRB-
cord-012902-efprpk72	206	27	was	be	VBD
cord-012902-efprpk72	206	28	128.5	128.5	CD
cord-012902-efprpk72	206	29	+	+	SYM
cord-012902-efprpk72	206	30	17.7/79.1	17.7/79.1	CD
cord-012902-efprpk72	206	31	+	+	SYM
cord-012902-efprpk72	206	32	11.1	11.1	CD
cord-012902-efprpk72	206	33	mmHg	mmHg	NNS
cord-012902-efprpk72	206	34	.	.	.
cord-012902-efprpk72	207	1	This	this	DT
cord-012902-efprpk72	207	2	was	be	VBD
cord-012902-efprpk72	207	3	significantly	significantly	RB
cord-012902-efprpk72	207	4	lower	low	JJR
cord-012902-efprpk72	207	5	than	than	IN
cord-012902-efprpk72	207	6	the	the	DT
cord-012902-efprpk72	207	7	first	first	JJ
cord-012902-efprpk72	207	8	BP	BP	NNP
cord-012902-efprpk72	207	9	reading	read	VBG
cord-012902-efprpk72	207	10	alone	alone	JJ
cord-012902-efprpk72	207	11	(	(	-LRB-
cord-012902-efprpk72	207	12	p	p	NN
cord-012902-efprpk72	207	13	<	<	XX
cord-012902-efprpk72	207	14	0.001	0.001	CD
cord-012902-efprpk72	207	15	for	for	IN
cord-012902-efprpk72	207	16	both	both	CC
cord-012902-efprpk72	207	17	SBP	SBP	NNP
cord-012902-efprpk72	207	18	and	and	CC
cord-012902-efprpk72	207	19	DBP	DBP	NNP
cord-012902-efprpk72	207	20	)	)	-RRB-
cord-012902-efprpk72	207	21	.	.	.
cord-012902-efprpk72	208	1	Women	woman	NNS
cord-012902-efprpk72	208	2	were	be	VBD
cord-012902-efprpk72	208	3	more	more	RBR
cord-012902-efprpk72	208	4	likely	likely	JJ
cord-012902-efprpk72	208	5	to	to	TO
cord-012902-efprpk72	208	6	have	have	VB
cord-012902-efprpk72	208	7	only	only	RB
cord-012902-efprpk72	208	8	one	one	CD
cord-012902-efprpk72	208	9	reading	reading	NN
cord-012902-efprpk72	208	10	.	.	.
cord-012902-efprpk72	209	1	In	in	IN
cord-012902-efprpk72	209	2	those	those	DT
cord-012902-efprpk72	209	3	with	with	IN
cord-012902-efprpk72	209	4	3	3	CD
cord-012902-efprpk72	209	5	BP	BP	NNP
cord-012902-efprpk72	209	6	readings	reading	NNS
cord-012902-efprpk72	209	7	,	,	,
cord-012902-efprpk72	209	8	1438	1438	CD
cord-012902-efprpk72	209	9	individuals	individual	NNS
cord-012902-efprpk72	209	10	(	(	-LRB-
cord-012902-efprpk72	209	11	of	of	IN
cord-012902-efprpk72	209	12	which	which	WDT
cord-012902-efprpk72	209	13	471	471	CD
cord-012902-efprpk72	209	14	were	be	VBD
cord-012902-efprpk72	209	15	on	on	IN
cord-012902-efprpk72	209	16	antihypertensive	antihypertensive	JJ
cord-012902-efprpk72	209	17	medication	medication	NN
cord-012902-efprpk72	209	18	)	)	-RRB-
cord-012902-efprpk72	209	19	had	have	VBD
cord-012902-efprpk72	209	20	BP	BP	NNP
cord-012902-efprpk72	209	21	in	in	IN
cord-012902-efprpk72	209	22	the	the	DT
cord-012902-efprpk72	209	23	hypertensive	hypertensive	JJ
cord-012902-efprpk72	209	24	range	range	NN
cord-012902-efprpk72	209	25	.	.	.
cord-012902-efprpk72	210	1	This	this	DT
cord-012902-efprpk72	210	2	works	work	VBZ
cord-012902-efprpk72	210	3	out	out	RP
cord-012902-efprpk72	210	4	to	to	IN
cord-012902-efprpk72	210	5	47.7	47.7	CD
cord-012902-efprpk72	210	6	%	%	NN
cord-012902-efprpk72	210	7	of	of	IN
cord-012902-efprpk72	210	8	patients	patient	NNS
cord-012902-efprpk72	210	9	on	on	IN
cord-012902-efprpk72	210	10	medications	medication	NNS
cord-012902-efprpk72	210	11	(	(	-LRB-
cord-012902-efprpk72	210	12	n	n	NN
cord-012902-efprpk72	210	13	=	=	SYM
cord-012902-efprpk72	210	14	988	988	CD
cord-012902-efprpk72	210	15	)	)	-RRB-
cord-012902-efprpk72	210	16	having	have	VBG
cord-012902-efprpk72	210	17	uncontrolled	uncontrolled	JJ
cord-012902-efprpk72	210	18	BP	BP	NNP
cord-012902-efprpk72	210	19	.	.	.
cord-012902-efprpk72	211	1	The	the	DT
cord-012902-efprpk72	211	2	remaining	remain	VBG
cord-012902-efprpk72	211	3	967	967	CD
cord-012902-efprpk72	211	4	were	be	VBD
cord-012902-efprpk72	211	5	newly	newly	RB
cord-012902-efprpk72	211	6	diagnosed	diagnose	VBN
cord-012902-efprpk72	211	7	hypertensive	hypertensive	JJ
cord-012902-efprpk72	211	8	.	.	.
cord-012902-efprpk72	212	1	The	the	DT
cord-012902-efprpk72	212	2	number	number	NN
cord-012902-efprpk72	212	3	of	of	IN
cord-012902-efprpk72	212	4	hypertensives	hypertensive	NNS
cord-012902-efprpk72	212	5	in	in	IN
cord-012902-efprpk72	212	6	our	-PRON-	PRP$
cord-012902-efprpk72	212	7	sample	sample	NN
cord-012902-efprpk72	212	8	therefore	therefore	RB
cord-012902-efprpk72	212	9	was	be	VBD
cord-012902-efprpk72	212	10	1955	1955	CD
cord-012902-efprpk72	212	11	,	,	,
cord-012902-efprpk72	212	12	giving	give	VBG
cord-012902-efprpk72	212	13	a	a	DT
cord-012902-efprpk72	212	14	proportion	proportion	NN
cord-012902-efprpk72	212	15	of	of	IN
cord-012902-efprpk72	212	16	32.9	32.9	CD
cord-012902-efprpk72	212	17	%	%	NN
cord-012902-efprpk72	212	18	of	of	IN
cord-012902-efprpk72	212	19	hypertensive	hypertensive	JJ
cord-012902-efprpk72	212	20	individuals	individual	NNS
cord-012902-efprpk72	212	21	(	(	-LRB-
cord-012902-efprpk72	212	22	of	of	IN
cord-012902-efprpk72	212	23	those	those	DT
cord-012902-efprpk72	212	24	with	with	IN
cord-012902-efprpk72	212	25	three	three	CD
cord-012902-efprpk72	212	26	BP	BP	NNP
cord-012902-efprpk72	212	27	readings	reading	NNS
cord-012902-efprpk72	212	28	)	)	-RRB-
cord-012902-efprpk72	212	29	in	in	IN
cord-012902-efprpk72	212	30	our	-PRON-	PRP$
cord-012902-efprpk72	212	31	sample	sample	NN
cord-012902-efprpk72	212	32	.	.	.
cord-012902-efprpk72	213	1	Pregnant	pregnant	JJ
cord-012902-efprpk72	213	2	women	woman	NNS
cord-012902-efprpk72	213	3	had	have	VBD
cord-012902-efprpk72	213	4	significantly	significantly	RB
cord-012902-efprpk72	213	5	lower	low	JJR
cord-012902-efprpk72	213	6	BP	BP	NNP
cord-012902-efprpk72	213	7	readings	reading	NNS
cord-012902-efprpk72	213	8	than	than	IN
cord-012902-efprpk72	213	9	non	non	JJ
cord-012902-efprpk72	213	10	-	-	JJ
cord-012902-efprpk72	213	11	pregnant	pregnant	JJ
cord-012902-efprpk72	213	12	women	woman	NNS
cord-012902-efprpk72	213	13	.	.	.
cord-012902-efprpk72	214	1	The	the	DT
cord-012902-efprpk72	214	2	factors	factor	NNS
cord-012902-efprpk72	214	3	predicting	predict	VBG
cord-012902-efprpk72	214	4	BP	BP	NNP
cord-012902-efprpk72	214	5	in	in	IN
cord-012902-efprpk72	214	6	the	the	DT
cord-012902-efprpk72	214	7	hypertensive	hypertensive	JJ
cord-012902-efprpk72	214	8	range	range	NN
cord-012902-efprpk72	214	9	were	be	VBD
cord-012902-efprpk72	214	10	age	age	NN
cord-012902-efprpk72	214	11	,	,	,
cord-012902-efprpk72	214	12	sex	sex	NN
cord-012902-efprpk72	214	13	,	,	,
cord-012902-efprpk72	214	14	previous	previous	JJ
cord-012902-efprpk72	214	15	stroke	stroke	NN
cord-012902-efprpk72	214	16	,	,	,
cord-012902-efprpk72	214	17	but	but	CC
cord-012902-efprpk72	214	18	not	not	RB
cord-012902-efprpk72	214	19	diabetes	diabetes	NN
cord-012902-efprpk72	214	20	,	,	,
cord-012902-efprpk72	214	21	previous	previous	JJ
cord-012902-efprpk72	214	22	MI	MI	NNP
cord-012902-efprpk72	214	23	or	or	CC
cord-012902-efprpk72	214	24	ethnicity	ethnicity	NN
cord-012902-efprpk72	214	25	.	.	.
cord-012902-efprpk72	215	1	Conclusions	conclusion	NNS
cord-012902-efprpk72	215	2	:	:	:
cord-012902-efprpk72	216	1	In	in	IN
cord-012902-efprpk72	216	2	Oman	Oman	NNP
cord-012902-efprpk72	216	3	,	,	,
cord-012902-efprpk72	216	4	the	the	DT
cord-012902-efprpk72	216	5	proportion	proportion	NN
cord-012902-efprpk72	216	6	of	of	IN
cord-012902-efprpk72	216	7	individuals	individual	NNS
cord-012902-efprpk72	216	8	having	have	VBG
cord-012902-efprpk72	216	9	hypertension	hypertension	NN
cord-012902-efprpk72	216	10	is	be	VBZ
cord-012902-efprpk72	216	11	comparable	comparable	JJ
cord-012902-efprpk72	216	12	to	to	IN
cord-012902-efprpk72	216	13	previous	previous	JJ
cord-012902-efprpk72	216	14	estimates	estimate	NNS
cord-012902-efprpk72	216	15	and	and	CC
cord-012902-efprpk72	216	16	surveys	survey	NNS
cord-012902-efprpk72	216	17	[	[	-LRB-
cord-012902-efprpk72	216	18	3	3	CD
cord-012902-efprpk72	216	19	]	]	-RRB-
cord-012902-efprpk72	216	20	.	.	.
cord-012902-efprpk72	217	1	More	More	JJR
cord-012902-efprpk72	217	2	needs	need	NNS
cord-012902-efprpk72	217	3	to	to	TO
cord-012902-efprpk72	217	4	be	be	VB
cord-012902-efprpk72	217	5	done	do	VBN
cord-012902-efprpk72	217	6	to	to	TO
cord-012902-efprpk72	217	7	educate	educate	VB
cord-012902-efprpk72	217	8	the	the	DT
cord-012902-efprpk72	217	9	public	public	NN
cord-012902-efprpk72	217	10	regarding	regard	VBG
cord-012902-efprpk72	217	11	BP	BP	NNP
cord-012902-efprpk72	217	12	checks	check	NNS
cord-012902-efprpk72	217	13	and	and	CC
cord-012902-efprpk72	217	14	the	the	DT
cord-012902-efprpk72	217	15	need	need	NN
cord-012902-efprpk72	217	16	for	for	IN
cord-012902-efprpk72	217	17	better	well	JJR
cord-012902-efprpk72	217	18	BP	BP	NNP
cord-012902-efprpk72	217	19	control	control	NN
cord-012902-efprpk72	217	20	.	.	.
cord-012902-efprpk72	218	1	Disclosures	disclosure	NNS
cord-012902-efprpk72	218	2	:	:	:
cord-012902-efprpk72	219	1	The	the	DT
cord-012902-efprpk72	219	2	authors	author	NNS
cord-012902-efprpk72	219	3	have	have	VBP
cord-012902-efprpk72	219	4	no	no	DT
cord-012902-efprpk72	219	5	conflicts	conflict	NNS
cord-012902-efprpk72	219	6	of	of	IN
cord-012902-efprpk72	219	7	interest	interest	NN
cord-012902-efprpk72	219	8	or	or	CC
cord-012902-efprpk72	219	9	relevant	relevant	JJ
cord-012902-efprpk72	219	10	disclosures	disclosure	NNS
cord-012902-efprpk72	219	11	.	.	.
cord-012902-efprpk72	220	1	Introduction	introduction	NN
cord-012902-efprpk72	220	2	:	:	:
cord-012902-efprpk72	221	1	Identifying	identify	VBG
cord-012902-efprpk72	221	2	primary	primary	JJ
cord-012902-efprpk72	221	3	hyperaldosteronism	hyperaldosteronism	NN
cord-012902-efprpk72	221	4	(	(	-LRB-
cord-012902-efprpk72	221	5	PH	PH	NNP
cord-012902-efprpk72	221	6	)	)	-RRB-
cord-012902-efprpk72	221	7	is	be	VBZ
cord-012902-efprpk72	221	8	important	important	JJ
cord-012902-efprpk72	221	9	;	;	:
cord-012902-efprpk72	221	10	patients	patient	NNS
cord-012902-efprpk72	221	11	may	may	MD
cord-012902-efprpk72	221	12	benefit	benefit	VB
cord-012902-efprpk72	221	13	from	from	IN
cord-012902-efprpk72	221	14	specific	specific	JJ
cord-012902-efprpk72	221	15	surgical	surgical	JJ
cord-012902-efprpk72	221	16	or	or	CC
cord-012902-efprpk72	221	17	drug	drug	NN
cord-012902-efprpk72	221	18	therapy	therapy	NN
cord-012902-efprpk72	221	19	.	.	.
cord-012902-efprpk72	222	1	However	however	RB
cord-012902-efprpk72	222	2	,	,	,
cord-012902-efprpk72	222	3	measuring	measure	VBG
cord-012902-efprpk72	222	4	renin	renin	NN
cord-012902-efprpk72	222	5	and	and	CC
cord-012902-efprpk72	222	6	aldosterone	aldosterone	NN
cord-012902-efprpk72	222	7	is	be	VBZ
cord-012902-efprpk72	222	8	unsuitable	unsuitable	JJ
cord-012902-efprpk72	222	9	for	for	IN
cord-012902-efprpk72	222	10	screening	screen	VBG
cord-012902-efprpk72	222	11	large	large	JJ
cord-012902-efprpk72	222	12	cohorts	cohort	NNS
cord-012902-efprpk72	222	13	.	.	.
cord-012902-efprpk72	223	1	Reports	report	NNS
cord-012902-efprpk72	223	2	suggest	suggest	VBP
cord-012902-efprpk72	223	3	that	that	IN
cord-012902-efprpk72	223	4	serum	serum	NN
cord-012902-efprpk72	223	5	and	and	CC
cord-012902-efprpk72	223	6	urine	urine	NN
cord-012902-efprpk72	223	7	electrolytes	electrolyte	NNS
cord-012902-efprpk72	223	8	may	may	MD
cord-012902-efprpk72	223	9	be	be	VB
cord-012902-efprpk72	223	10	a	a	DT
cord-012902-efprpk72	223	11	useful	useful	JJ
cord-012902-efprpk72	223	12	indicator	indicator	NN
cord-012902-efprpk72	223	13	of	of	IN
cord-012902-efprpk72	223	14	PH	PH	NNP
cord-012902-efprpk72	223	15	.	.	.
cord-012902-efprpk72	224	1	We	-PRON-	PRP
cord-012902-efprpk72	224	2	compared	compare	VBD
cord-012902-efprpk72	224	3	serum	serum	NN
cord-012902-efprpk72	224	4	and	and	CC
cord-012902-efprpk72	224	5	urine	urine	NN
cord-012902-efprpk72	224	6	biochemistry	biochemistry	NN
cord-012902-efprpk72	224	7	in	in	IN
cord-012902-efprpk72	224	8	PH	PH	NNP
cord-012902-efprpk72	224	9	and	and	CC
cord-012902-efprpk72	224	10	control	control	NN
cord-012902-efprpk72	224	11	patients	patient	NNS
cord-012902-efprpk72	224	12	.	.	.
cord-012902-efprpk72	225	1	Methods	method	NNS
cord-012902-efprpk72	225	2	:	:	:
cord-012902-efprpk72	225	3	12	12	CD
cord-012902-efprpk72	225	4	patients	patient	NNS
cord-012902-efprpk72	225	5	with	with	IN
cord-012902-efprpk72	225	6	subsequent	subsequent	JJ
cord-012902-efprpk72	225	7	diagnosis	diagnosis	NN
cord-012902-efprpk72	225	8	of	of	IN
cord-012902-efprpk72	225	9	PH	PH	NNP
cord-012902-efprpk72	225	10	made	make	VBN
cord-012902-efprpk72	225	11	by	by	IN
cord-012902-efprpk72	225	12	adrenal	adrenal	JJ
cord-012902-efprpk72	225	13	vein	vein	NN
cord-012902-efprpk72	225	14	sampling	sampling	NN
cord-012902-efprpk72	225	15	or	or	CC
cord-012902-efprpk72	225	16	etomidate	etomidate	NN
cord-012902-efprpk72	225	17	imaging	imaging	NN
cord-012902-efprpk72	225	18	,	,	,
cord-012902-efprpk72	225	19	had	have	VBD
cord-012902-efprpk72	225	20	their	-PRON-	PRP$
cord-012902-efprpk72	225	21	pre	pre	JJ
cord-012902-efprpk72	225	22	-	-	JJ
cord-012902-efprpk72	225	23	diagnosis	diagnosis	JJ
cord-012902-efprpk72	225	24	serum	serum	NN
cord-012902-efprpk72	225	25	and	and	CC
cord-012902-efprpk72	225	26	urinary	urinary	JJ
cord-012902-efprpk72	225	27	biochemistry	biochemistry	NN
cord-012902-efprpk72	225	28	recorded	record	VBN
cord-012902-efprpk72	225	29	.	.	.
cord-012902-efprpk72	226	1	Control	control	NN
cord-012902-efprpk72	226	2	patients	patient	NNS
cord-012902-efprpk72	226	3	(	(	-LRB-
cord-012902-efprpk72	226	4	CTRL	CTRL	NNP
cord-012902-efprpk72	226	5	)	)	-RRB-
cord-012902-efprpk72	226	6	comprised	comprise	VBD
cord-012902-efprpk72	226	7	24	24	CD
cord-012902-efprpk72	226	8	age	age	NN
cord-012902-efprpk72	226	9	and	and	CC
cord-012902-efprpk72	226	10	gender	gender	NN
cord-012902-efprpk72	226	11	-	-	HYPH
cord-012902-efprpk72	226	12	matched	match	VBN
cord-012902-efprpk72	226	13	hypertensives	hypertensive	NNS
cord-012902-efprpk72	226	14	in	in	IN
cord-012902-efprpk72	226	15	whom	whom	WP
cord-012902-efprpk72	226	16	PH	PH	NNP
cord-012902-efprpk72	226	17	had	have	VBD
cord-012902-efprpk72	226	18	been	be	VBN
cord-012902-efprpk72	226	19	excluded	exclude	VBN
cord-012902-efprpk72	226	20	.	.	.
cord-012902-efprpk72	227	1	No	no	DT
cord-012902-efprpk72	227	2	patients	patient	NNS
cord-012902-efprpk72	227	3	were	be	VBD
cord-012902-efprpk72	227	4	taking	take	VBG
cord-012902-efprpk72	227	5	antihypertensives	antihypertensive	NNS
cord-012902-efprpk72	227	6	except	except	IN
cord-012902-efprpk72	227	7	diltiazem	diltiazem	NN
cord-012902-efprpk72	227	8	and/or	and/or	CC
cord-012902-efprpk72	227	9	doxazosin	doxazosin	NNP
cord-012902-efprpk72	227	10	.	.	.
cord-012902-efprpk72	228	1	Results	result	NNS
cord-012902-efprpk72	228	2	:	:	:
cord-012902-efprpk72	229	1	PH	PH	NNP
cord-012902-efprpk72	229	2	patients	patient	NNS
cord-012902-efprpk72	229	3	had	have	VBD
cord-012902-efprpk72	229	4	a	a	DT
cord-012902-efprpk72	229	5	significantly	significantly	RB
cord-012902-efprpk72	229	6	lower	low	JJR
cord-012902-efprpk72	229	7	serum	serum	NN
cord-012902-efprpk72	229	8	potassium	potassium	NN
cord-012902-efprpk72	229	9	than	than	IN
cord-012902-efprpk72	229	10	CTRL	CTRL	NNP
cord-012902-efprpk72	229	11	.5	.5	.
cord-012902-efprpk72	230	1	mmol	mmol	NNP
cord-012902-efprpk72	230	2	/	/	SYM
cord-012902-efprpk72	230	3	L	L	NNP
cord-012902-efprpk72	230	4	,	,	,
cord-012902-efprpk72	230	5	p	p	NN
cord-012902-efprpk72	230	6	=	=	SYM
cord-012902-efprpk72	230	7	0.002	0.002	CD
cord-012902-efprpk72	231	1	)	)	-RRB-
cord-012902-efprpk72	231	2	;	;	:
cord-012902-efprpk72	231	3	it	-PRON-	PRP
cord-012902-efprpk72	231	4	was	be	VBD
cord-012902-efprpk72	231	5	a	a	DT
cord-012902-efprpk72	231	6	good	good	JJ
cord-012902-efprpk72	231	7	discriminator	discriminator	NN
cord-012902-efprpk72	231	8	between	between	IN
cord-012902-efprpk72	231	9	PH	PH	NNP
cord-012902-efprpk72	231	10	and	and	CC
cord-012902-efprpk72	231	11	CTRL	CTRL	NNP
cord-012902-efprpk72	231	12	(	(	-LRB-
cord-012902-efprpk72	232	1	receiver	receiver	NN
cord-012902-efprpk72	232	2	operator	operator	NN
cord-012902-efprpk72	232	3	characteristic	characteristic	NN
cord-012902-efprpk72	232	4	(	(	-LRB-
cord-012902-efprpk72	232	5	ROC	ROC	NNP
cord-012902-efprpk72	232	6	)	)	-RRB-
cord-012902-efprpk72	232	7	AUC	AUC	NNP
cord-012902-efprpk72	232	8	=	=	SYM
cord-012902-efprpk72	232	9	0.8	0.8	CD
cord-012902-efprpk72	232	10	,	,	,
cord-012902-efprpk72	232	11	p	p	NN
cord-012902-efprpk72	232	12	=	=	SYM
cord-012902-efprpk72	232	13	0.003	0.003	CD
cord-012902-efprpk72	232	14	)	)	-RRB-
cord-012902-efprpk72	232	15	.	.	.
cord-012902-efprpk72	233	1	There	there	EX
cord-012902-efprpk72	233	2	was	be	VBD
cord-012902-efprpk72	233	3	no	no	DT
cord-012902-efprpk72	233	4	significant	significant	JJ
cord-012902-efprpk72	233	5	difference	difference	NN
cord-012902-efprpk72	233	6	in	in	IN
cord-012902-efprpk72	233	7	the	the	DT
cord-012902-efprpk72	233	8	aldosterone	aldosterone	NN
cord-012902-efprpk72	233	9	(	(	-LRB-
cord-012902-efprpk72	233	10	PH	PH	NNP
cord-012902-efprpk72	233	11	680	680	CD
cord-012902-efprpk72	233	12	IQR	IQR	NNP
cord-012902-efprpk72	233	13	470	470	CD
cord-012902-efprpk72	233	14	-	-	SYM
cord-012902-efprpk72	233	15	1390	1390	CD
cord-012902-efprpk72	233	16	CTRL	ctrl	NN
cord-012902-efprpk72	233	17	380	380	CD
cord-012902-efprpk72	233	18	IQR	IQR	NNP
cord-012902-efprpk72	233	19	289	289	CD
cord-012902-efprpk72	233	20	-	-	HYPH
cord-012902-efprpk72	233	21	1083	1083	CD
cord-012902-efprpk72	233	22	pmol	pmol	NN
cord-012902-efprpk72	233	23	,	,	,
cord-012902-efprpk72	233	24	ns	ns	NNP
cord-012902-efprpk72	233	25	)	)	-RRB-
cord-012902-efprpk72	233	26	.	.	.
cord-012902-efprpk72	234	1	However	however	RB
cord-012902-efprpk72	234	2	,	,	,
cord-012902-efprpk72	234	3	the	the	DT
cord-012902-efprpk72	234	4	renin	renin	NN
cord-012902-efprpk72	234	5	was	be	VBD
cord-012902-efprpk72	234	6	lower	low	JJR
cord-012902-efprpk72	234	7	in	in	IN
cord-012902-efprpk72	234	8	PH	PH	NNP
cord-012902-efprpk72	234	9	than	than	IN
cord-012902-efprpk72	234	10	CTRL	CTRL	NNP
cord-012902-efprpk72	235	1	(	(	-LRB-
cord-012902-efprpk72	235	2	PH	PH	NNP
cord-012902-efprpk72	235	3	0.3	0.3	CD
cord-012902-efprpk72	235	4	IQR	IQR	NNP
cord-012902-efprpk72	235	5	0.3	0.3	CD
cord-012902-efprpk72	235	6	-	-	HYPH
cord-012902-efprpk72	235	7	0.48	0.48	CD
cord-012902-efprpk72	235	8	vs	vs	IN
cord-012902-efprpk72	235	9	CTRL	ctrl	NN
cord-012902-efprpk72	235	10	0.97	0.97	CD
cord-012902-efprpk72	235	11	IQR	IQR	NNP
cord-012902-efprpk72	235	12	0.37	0.37	CD
cord-012902-efprpk72	235	13	-	-	SYM
cord-012902-efprpk72	235	14	1.48	1.48	CD
cord-012902-efprpk72	235	15	ng	ng	NN
cord-012902-efprpk72	235	16	/	/	SYM
cord-012902-efprpk72	235	17	mL	ml	NN
cord-012902-efprpk72	235	18	/	/	SYM
cord-012902-efprpk72	235	19	h	h	NN
cord-012902-efprpk72	235	20	)	)	-RRB-
cord-012902-efprpk72	235	21	,	,	,
cord-012902-efprpk72	235	22	p	p	NN
cord-012902-efprpk72	235	23	=	=	SYM
cord-012902-efprpk72	235	24	0.014	0.014	CD
cord-012902-efprpk72	235	25	)	)	-RRB-
cord-012902-efprpk72	235	26	.	.	.
cord-012902-efprpk72	236	1	There	there	EX
cord-012902-efprpk72	236	2	was	be	VBD
cord-012902-efprpk72	236	3	no	no	DT
cord-012902-efprpk72	236	4	correlation	correlation	NN
cord-012902-efprpk72	236	5	between	between	IN
cord-012902-efprpk72	236	6	the	the	DT
cord-012902-efprpk72	236	7	serum	serum	NN
cord-012902-efprpk72	236	8	potassium	potassium	NN
cord-012902-efprpk72	236	9	and	and	CC
cord-012902-efprpk72	236	10	renin	renin	NN
cord-012902-efprpk72	236	11	in	in	IN
cord-012902-efprpk72	236	12	PH	PH	NNP
cord-012902-efprpk72	236	13	(	(	-LRB-
cord-012902-efprpk72	236	14	R	r	NN
cord-012902-efprpk72	236	15	=	=	SYM
cord-012902-efprpk72	236	16	0.298	0.298	CD
cord-012902-efprpk72	236	17	,	,	,
cord-012902-efprpk72	236	18	p	p	NN
cord-012902-efprpk72	236	19	>	>	XX
cord-012902-efprpk72	236	20	0.99	0.99	CD
cord-012902-efprpk72	236	21	)	)	-RRB-
cord-012902-efprpk72	236	22	or	or	CC
cord-012902-efprpk72	236	23	CTRL	CTRL	NNP
cord-012902-efprpk72	236	24	(	(	-LRB-
cord-012902-efprpk72	236	25	R	r	NN
cord-012902-efprpk72	236	26	=	=	SYM
cord-012902-efprpk72	236	27	−0.017	−0.017	NN
cord-012902-efprpk72	236	28	,	,	,
cord-012902-efprpk72	236	29	p	p	NN
cord-012902-efprpk72	236	30	>	>	XX
cord-012902-efprpk72	236	31	0.99	0.99	CD
cord-012902-efprpk72	236	32	)	)	-RRB-
cord-012902-efprpk72	236	33	.	.	.
cord-012902-efprpk72	237	1	Further	further	RB
cord-012902-efprpk72	237	2	,	,	,
cord-012902-efprpk72	237	3	there	there	EX
cord-012902-efprpk72	237	4	was	be	VBD
cord-012902-efprpk72	237	5	no	no	DT
cord-012902-efprpk72	237	6	difference	difference	NN
cord-012902-efprpk72	237	7	in	in	IN
cord-012902-efprpk72	237	8	the	the	DT
cord-012902-efprpk72	237	9	urinary	urinary	JJ
cord-012902-efprpk72	237	10	potassium	potassium	NN
cord-012902-efprpk72	237	11	(	(	-LRB-
cord-012902-efprpk72	237	12	PH	PH	NNP
cord-012902-efprpk72	237	13	45.5	45.5	CD
cord-012902-efprpk72	237	14	IQR	IQR	NNP
cord-012902-efprpk72	237	15	31.3	31.3	CD
cord-012902-efprpk72	237	16	-	-	HYPH
cord-012902-efprpk72	237	17	87.3	87.3	CD
cord-012902-efprpk72	237	18	vs	vs	IN
cord-012902-efprpk72	237	19	CTRL	CTRL	NNP
cord-012902-efprpk72	237	20	57.5	57.5	CD
cord-012902-efprpk72	237	21	IQR	IQR	NNP
cord-012902-efprpk72	237	22	37.5	37.5	CD
cord-012902-efprpk72	237	23	-	-	HYPH
cord-012902-efprpk72	237	24	70.8	70.8	CD
cord-012902-efprpk72	237	25	mmol	mmol	NNP
cord-012902-efprpk72	237	26	/	/	SYM
cord-012902-efprpk72	237	27	L	L	NNP
cord-012902-efprpk72	237	28	,	,	,
cord-012902-efprpk72	237	29	ns	ns	NNP
cord-012902-efprpk72	237	30	)	)	-RRB-
cord-012902-efprpk72	237	31	,	,	,
cord-012902-efprpk72	237	32	fractional	fractional	JJ
cord-012902-efprpk72	237	33	excretion	excretion	NN
cord-012902-efprpk72	237	34	of	of	IN
cord-012902-efprpk72	237	35	potassium	potassium	NN
cord-012902-efprpk72	237	36	(	(	-LRB-
cord-012902-efprpk72	237	37	FE	FE	NNP
cord-012902-efprpk72	237	38	K	K	NNP
cord-012902-efprpk72	237	39	)	)	-RRB-
cord-012902-efprpk72	238	1	(	(	-LRB-
cord-012902-efprpk72	238	2	PH	PH	NNP
cord-012902-efprpk72	238	3	17.5	17.5	CD
cord-012902-efprpk72	238	4	IQR	IQR	NNP
cord-012902-efprpk72	238	5	9	9	CD
cord-012902-efprpk72	238	6	-	-	SYM
cord-012902-efprpk72	238	7	19.8	19.8	CD
cord-012902-efprpk72	238	8	vs	vs	IN
cord-012902-efprpk72	238	9	CTRL	CTRL	NNP
cord-012902-efprpk72	238	10	10.9	10.9	CD
cord-012902-efprpk72	238	11	IQR	IQR	NNP
cord-012902-efprpk72	238	12	9.7	9.7	CD
cord-012902-efprpk72	238	13	-	-	SYM
cord-012902-efprpk72	238	14	16.3	16.3	CD
cord-012902-efprpk72	238	15	%	%	NN
cord-012902-efprpk72	238	16	,	,	,
cord-012902-efprpk72	238	17	ns	ns	NNP
cord-012902-efprpk72	238	18	)	)	-RRB-
cord-012902-efprpk72	238	19	,	,	,
cord-012902-efprpk72	238	20	FE	FE	NNP
cord-012902-efprpk72	238	21	Na	Na	NNP
cord-012902-efprpk72	238	22	(	(	-LRB-
cord-012902-efprpk72	238	23	PH	ph	NN
cord-012902-efprpk72	238	24	0.46	0.46	CD
cord-012902-efprpk72	238	25	IQR	IQR	NNP
cord-012902-efprpk72	238	26	0.16	0.16	CD
cord-012902-efprpk72	238	27	-	-	HYPH
cord-012902-efprpk72	238	28	0.79	0.79	CD
cord-012902-efprpk72	238	29	vs	vs	IN
cord-012902-efprpk72	238	30	CTRL	ctrl	NN
cord-012902-efprpk72	238	31	0.54	0.54	CD
cord-012902-efprpk72	238	32	IQR	IQR	NNP
cord-012902-efprpk72	238	33	0.44	0.44	CD
cord-012902-efprpk72	238	34	-	-	HYPH
cord-012902-efprpk72	238	35	0.67	0.67	CD
cord-012902-efprpk72	238	36	%	%	NN
cord-012902-efprpk72	238	37	,	,	,
cord-012902-efprpk72	238	38	ns	ns	NNP
cord-012902-efprpk72	238	39	)	)	-RRB-
cord-012902-efprpk72	238	40	,	,	,
cord-012902-efprpk72	238	41	nor	nor	CC
cord-012902-efprpk72	238	42	the	the	DT
cord-012902-efprpk72	238	43	ratio	ratio	NN
cord-012902-efprpk72	238	44	of	of	IN
cord-012902-efprpk72	238	45	FE	FE	NNP
cord-012902-efprpk72	238	46	K	K	NNP
cord-012902-efprpk72	238	47	/FE	/FE	NFP
cord-012902-efprpk72	238	48	Na	Na	NNP
cord-012902-efprpk72	238	49	(	(	-LRB-
cord-012902-efprpk72	238	50	PH	PH	NNP
cord-012902-efprpk72	238	51	38.6	38.6	CD
cord-012902-efprpk72	238	52	IQR	IQR	NNP
cord-012902-efprpk72	238	53	23	23	CD
cord-012902-efprpk72	238	54	.	.	.
cord-012902-efprpk72	238	55	ns	ns	IN
cord-012902-efprpk72	238	56	)	)	-RRB-
cord-012902-efprpk72	238	57	.	.	.
cord-012902-efprpk72	239	1	Conclusions	conclusion	NNS
cord-012902-efprpk72	239	2	:	:	:
cord-012902-efprpk72	240	1	The	the	DT
cord-012902-efprpk72	240	2	serum	serum	NN
cord-012902-efprpk72	240	3	potassium	potassium	NN
cord-012902-efprpk72	240	4	discriminated	discriminate	VBN
cord-012902-efprpk72	240	5	between	between	IN
cord-012902-efprpk72	240	6	PH	PH	NNP
cord-012902-efprpk72	240	7	and	and	CC
cord-012902-efprpk72	240	8	hypertensive	hypertensive	JJ
cord-012902-efprpk72	240	9	controls	control	NNS
cord-012902-efprpk72	240	10	as	as	RB
cord-012902-efprpk72	240	11	well	well	RB
cord-012902-efprpk72	240	12	as	as	IN
cord-012902-efprpk72	240	13	renin	renin	NN
cord-012902-efprpk72	240	14	.	.	.
cord-012902-efprpk72	241	1	There	there	EX
cord-012902-efprpk72	241	2	was	be	VBD
cord-012902-efprpk72	241	3	no	no	DT
cord-012902-efprpk72	241	4	significant	significant	JJ
cord-012902-efprpk72	241	5	difference	difference	NN
cord-012902-efprpk72	241	6	in	in	IN
cord-012902-efprpk72	241	7	either	either	CC
cord-012902-efprpk72	241	8	the	the	DT
cord-012902-efprpk72	241	9	FE	FE	NNP
cord-012902-efprpk72	241	10	Na	Na	NNP
cord-012902-efprpk72	241	11	or	or	CC
cord-012902-efprpk72	241	12	FE	FE	NNP
cord-012902-efprpk72	241	13	K	K	NNP
cord-012902-efprpk72	241	14	.	.	.
cord-012902-efprpk72	242	1	This	this	DT
cord-012902-efprpk72	242	2	implies	imply	VBZ
cord-012902-efprpk72	242	3	that	that	IN
cord-012902-efprpk72	242	4	despite	despite	IN
cord-012902-efprpk72	242	5	hyperkaliuria	hyperkaliuria	NNP
cord-012902-efprpk72	242	6	,	,	,
cord-012902-efprpk72	242	7	urinary	urinary	JJ
cord-012902-efprpk72	242	8	electrolytes	electrolyte	NNS
cord-012902-efprpk72	242	9	are	be	VBP
cord-012902-efprpk72	242	10	of	of	IN
cord-012902-efprpk72	242	11	no	no	DT
cord-012902-efprpk72	242	12	use	use	NN
cord-012902-efprpk72	242	13	in	in	IN
cord-012902-efprpk72	242	14	screening	screening	NN
cord-012902-efprpk72	242	15	for	for	IN
cord-012902-efprpk72	242	16	PH	PH	NNP
cord-012902-efprpk72	242	17	.	.	.
cord-012902-efprpk72	243	1	These	these	DT
cord-012902-efprpk72	243	2	data	datum	NNS
cord-012902-efprpk72	243	3	require	require	VBP
cord-012902-efprpk72	243	4	further	further	JJ
cord-012902-efprpk72	243	5	evaluation	evaluation	NN
cord-012902-efprpk72	243	6	in	in	IN
cord-012902-efprpk72	243	7	larger	large	JJR
cord-012902-efprpk72	243	8	,	,	,
cord-012902-efprpk72	243	9	more	more	RBR
cord-012902-efprpk72	243	10	defined	defined	JJ
cord-012902-efprpk72	243	11	cohorts	cohort	NNS
cord-012902-efprpk72	243	12	.	.	.
cord-012902-efprpk72	244	1	Disclosures	disclosure	NNS
cord-012902-efprpk72	244	2	:	:	:
cord-012902-efprpk72	244	3	None	none	NN
cord-012902-efprpk72	244	4	.	.	.
cord-012902-efprpk72	245	1	Methods	method	NNS
cord-012902-efprpk72	245	2	:	:	:
cord-012902-efprpk72	246	1	We	-PRON-	PRP
cord-012902-efprpk72	246	2	used	use	VBD
cord-012902-efprpk72	246	3	the	the	DT
cord-012902-efprpk72	246	4	database	database	NN
cord-012902-efprpk72	246	5	of	of	IN
cord-012902-efprpk72	246	6	the	the	DT
cord-012902-efprpk72	246	7	Anglo	anglo	JJ
cord-012902-efprpk72	246	8	-	-	HYPH
cord-012902-efprpk72	246	9	Scandinavian	Scandinavian	NNP
cord-012902-efprpk72	246	10	Cardiac	Cardiac	NNP
cord-012902-efprpk72	246	11	Outcomes	Outcomes	NNPS
cord-012902-efprpk72	246	12	Trial	Trial	NNP
cord-012902-efprpk72	246	13	(	(	-LRB-
cord-012902-efprpk72	246	14	ASCOT	ASCOT	NNP
cord-012902-efprpk72	246	15	)	)	-RRB-
cord-012902-efprpk72	246	16	.	.	.
cord-012902-efprpk72	247	1	Our	-PRON-	PRP$
cord-012902-efprpk72	247	2	primary	primary	JJ
cord-012902-efprpk72	247	3	outcome	outcome	NN
cord-012902-efprpk72	247	4	was	be	VBD
cord-012902-efprpk72	247	5	composite	composite	JJ
cord-012902-efprpk72	247	6	of	of	IN
cord-012902-efprpk72	247	7	fatal	fatal	JJ
cord-012902-efprpk72	247	8	and	and	CC
cord-012902-efprpk72	247	9	non	non	JJ
cord-012902-efprpk72	247	10	-	-	JJ
cord-012902-efprpk72	247	11	fatal	fatal	JJ
cord-012902-efprpk72	247	12	CV	cv	NN
cord-012902-efprpk72	247	13	event	event	NN
cord-012902-efprpk72	247	14	including	include	VBG
cord-012902-efprpk72	247	15	:	:	:
cord-012902-efprpk72	247	16	coronary	coronary	JJ
cord-012902-efprpk72	247	17	heart	heart	NN
cord-012902-efprpk72	247	18	disease	disease	NN
cord-012902-efprpk72	247	19	,	,	,
cord-012902-efprpk72	247	20	stroke	stroke	NN
cord-012902-efprpk72	247	21	and	and	CC
cord-012902-efprpk72	247	22	coronary	coronary	JJ
cord-012902-efprpk72	247	23	re	re	NN
cord-012902-efprpk72	247	24	-	-	NN
cord-012902-efprpk72	247	25	vascularisation	vascularisation	NN
cord-012902-efprpk72	247	26	.	.	.
cord-012902-efprpk72	248	1	We	-PRON-	PRP
cord-012902-efprpk72	248	2	developed	develop	VBD
cord-012902-efprpk72	248	3	cox	cox	NNP
cord-012902-efprpk72	248	4	regression	regression	NN
cord-012902-efprpk72	248	5	models	model	NNS
cord-012902-efprpk72	248	6	separately	separately	RB
cord-012902-efprpk72	248	7	for	for	IN
cord-012902-efprpk72	248	8	each	each	DT
cord-012902-efprpk72	248	9	LVH	LVH	NNP
cord-012902-efprpk72	248	10	criterion	criterion	NN
cord-012902-efprpk72	248	11	(	(	-LRB-
cord-012902-efprpk72	248	12	Modified	modify	VBN
cord-012902-efprpk72	248	13	Sokolov	Sokolov	NNP
cord-012902-efprpk72	248	14	,	,	,
cord-012902-efprpk72	248	15	Cornell	Cornell	NNP
cord-012902-efprpk72	248	16	,	,	,
cord-012902-efprpk72	248	17	Framingham	Framingham	NNP
cord-012902-efprpk72	248	18	,	,	,
cord-012902-efprpk72	248	19	Strain	Strain	NNP
cord-012902-efprpk72	248	20	Pattern	Pattern	NNP
cord-012902-efprpk72	248	21	,	,	,
cord-012902-efprpk72	248	22	Cornell	Cornell	NNP
cord-012902-efprpk72	248	23	-	-	HYPH
cord-012902-efprpk72	248	24	Strain	Strain	NNP
cord-012902-efprpk72	248	25	,	,	,
cord-012902-efprpk72	248	26	Cornell	Cornell	NNP
cord-012902-efprpk72	248	27	-	-	HYPH
cord-012902-efprpk72	248	28	Product	Product	NNP
cord-012902-efprpk72	248	29	)	)	-RRB-
cord-012902-efprpk72	248	30	,	,	,
cord-012902-efprpk72	248	31	after	after	IN
cord-012902-efprpk72	248	32	adjusting	adjust	VBG
cord-012902-efprpk72	248	33	for	for	IN
cord-012902-efprpk72	248	34	a	a	DT
cord-012902-efprpk72	248	35	-	-	HYPH
cord-012902-efprpk72	248	36	priori	priori	JJ
cord-012902-efprpk72	248	37	confounders	confounder	NNS
cord-012902-efprpk72	248	38	(	(	-LRB-
cord-012902-efprpk72	248	39	age	age	NN
cord-012902-efprpk72	248	40	,	,	,
cord-012902-efprpk72	248	41	sex	sex	NN
cord-012902-efprpk72	248	42	,	,	,
cord-012902-efprpk72	248	43	smoking	smoking	NN
cord-012902-efprpk72	248	44	status	status	NN
cord-012902-efprpk72	248	45	,	,	,
cord-012902-efprpk72	248	46	diabetes	diabetes	NN
cord-012902-efprpk72	248	47	,	,	,
cord-012902-efprpk72	248	48	pulse	pulse	NN
cord-012902-efprpk72	248	49	pressure	pressure	NN
cord-012902-efprpk72	248	50	,	,	,
cord-012902-efprpk72	248	51	chronic	chronic	JJ
cord-012902-efprpk72	248	52	kidney	kidney	NN
cord-012902-efprpk72	248	53	disease	disease	NN
cord-012902-efprpk72	248	54	)	)	-RRB-
cord-012902-efprpk72	248	55	and	and	CC
cord-012902-efprpk72	248	56	other	other	JJ
cord-012902-efprpk72	248	57	confounders	confounder	NNS
cord-012902-efprpk72	248	58	found	find	VBN
cord-012902-efprpk72	248	59	using	use	VBG
cord-012902-efprpk72	248	60	stepwise	stepwise	JJ
cord-012902-efprpk72	248	61	selection	selection	NN
cord-012902-efprpk72	248	62	(	(	-LRB-
cord-012902-efprpk72	248	63	number	number	NN
cord-012902-efprpk72	248	64	of	of	IN
cord-012902-efprpk72	248	65	anti	anti	JJ
cord-012902-efprpk72	248	66	-	-	JJ
cord-012902-efprpk72	248	67	hypertensives	hypertensive	NNS
cord-012902-efprpk72	248	68	,	,	,
cord-012902-efprpk72	248	69	previous	previous	JJ
cord-012902-efprpk72	248	70	vascular	vascular	JJ
cord-012902-efprpk72	248	71	disease	disease	NN
cord-012902-efprpk72	248	72	,	,	,
cord-012902-efprpk72	248	73	metabolic	metabolic	JJ
cord-012902-efprpk72	248	74	syndrome	syndrome	NN
cord-012902-efprpk72	248	75	,	,	,
cord-012902-efprpk72	248	76	atrial	atrial	JJ
cord-012902-efprpk72	248	77	fibrillation	fibrillation	NN
cord-012902-efprpk72	248	78	)	)	-RRB-
cord-012902-efprpk72	248	79	.	.	.
cord-012902-efprpk72	249	1	We	-PRON-	PRP
cord-012902-efprpk72	249	2	compared	compare	VBD
cord-012902-efprpk72	249	3	discriminative	discriminative	JJ
cord-012902-efprpk72	249	4	ability	ability	NN
cord-012902-efprpk72	249	5	using	use	VBG
cord-012902-efprpk72	249	6	c	c	NN
cord-012902-efprpk72	249	7	-	-	HYPH
cord-012902-efprpk72	249	8	statistic	statistic	NN
cord-012902-efprpk72	249	9	,	,	,
cord-012902-efprpk72	249	10	goodness	goodness	NN
cord-012902-efprpk72	249	11	of	of	IN
cord-012902-efprpk72	249	12	fit	fit	NN
cord-012902-efprpk72	249	13	of	of	IN
cord-012902-efprpk72	249	14	the	the	DT
cord-012902-efprpk72	249	15	model	model	NN
cord-012902-efprpk72	249	16	using	use	VBG
cord-012902-efprpk72	249	17	Bayesian	bayesian	JJ
cord-012902-efprpk72	249	18	information	information	NN
cord-012902-efprpk72	249	19	criterion	criterion	NN
cord-012902-efprpk72	249	20	(	(	-LRB-
cord-012902-efprpk72	249	21	BIC	BIC	NNP
cord-012902-efprpk72	249	22	)	)	-RRB-
cord-012902-efprpk72	249	23	,	,	,
cord-012902-efprpk72	249	24	hazard	hazard	NN
cord-012902-efprpk72	249	25	ratios	ratio	NNS
cord-012902-efprpk72	249	26	(	(	-LRB-
cord-012902-efprpk72	249	27	HR	HR	NNP
cord-012902-efprpk72	249	28	)	)	-RRB-
cord-012902-efprpk72	249	29	and	and	CC
cord-012902-efprpk72	249	30	z	z	NN
cord-012902-efprpk72	249	31	-	-	HYPH
cord-012902-efprpk72	249	32	statistics	statistic	NNS
cord-012902-efprpk72	249	33	for	for	IN
cord-012902-efprpk72	249	34	strength	strength	NN
cord-012902-efprpk72	249	35	of	of	IN
cord-012902-efprpk72	249	36	association	association	NN
cord-012902-efprpk72	249	37	of	of	IN
cord-012902-efprpk72	249	38	each	each	DT
cord-012902-efprpk72	249	39	one	one	CD
cord-012902-efprpk72	249	40	of	of	IN
cord-012902-efprpk72	249	41	these	these	DT
cord-012902-efprpk72	249	42	LVH	LVH	NNP
cord-012902-efprpk72	249	43	criteria	criterion	NNS
cord-012902-efprpk72	249	44	in	in	IN
cord-012902-efprpk72	249	45	respective	respective	JJ
cord-012902-efprpk72	249	46	models	model	NNS
cord-012902-efprpk72	249	47	.	.	.
cord-012902-efprpk72	250	1	Results	result	NNS
cord-012902-efprpk72	250	2	:	:	:
cord-012902-efprpk72	251	1	9.7	9.7	CD
cord-012902-efprpk72	251	2	-	-	SYM
cord-012902-efprpk72	251	3	17.2	17.2	CD
cord-012902-efprpk72	251	4	%	%	NN
cord-012902-efprpk72	251	5	of	of	IN
cord-012902-efprpk72	251	6	17959	17959	CD
cord-012902-efprpk72	251	7	patients	patient	NNS
cord-012902-efprpk72	251	8	had	have	VBD
cord-012902-efprpk72	251	9	LVH	LVH	NNP
cord-012902-efprpk72	251	10	at	at	IN
cord-012902-efprpk72	251	11	baseline	baseline	NN
cord-012902-efprpk72	251	12	as	as	IN
cord-012902-efprpk72	251	13	defined	define	VBN
cord-012902-efprpk72	251	14	by	by	IN
cord-012902-efprpk72	251	15	one	one	CD
cord-012902-efprpk72	251	16	or	or	CC
cord-012902-efprpk72	251	17	more	more	JJR
cord-012902-efprpk72	251	18	LVH	LVH	NNP
cord-012902-efprpk72	251	19	criterion	criterion	NN
cord-012902-efprpk72	251	20	.	.	.
cord-012902-efprpk72	252	1	During	during	IN
cord-012902-efprpk72	252	2	a	a	DT
cord-012902-efprpk72	252	3	median	median	NN
cord-012902-efprpk72	252	4	follow	follow	NN
cord-012902-efprpk72	252	5	up	up	IN
cord-012902-efprpk72	252	6	of	of	IN
cord-012902-efprpk72	252	7	5.6	5.6	CD
cord-012902-efprpk72	252	8	years	year	NNS
cord-012902-efprpk72	252	9	(	(	-LRB-
cord-012902-efprpk72	252	10	IQR	IQR	NNP
cord-012902-efprpk72	252	11	5.2	5.2	CD
cord-012902-efprpk72	252	12	-	-	HYPH
cord-012902-efprpk72	252	13	6.1	6.1	CD
cord-012902-efprpk72	252	14	)	)	-RRB-
cord-012902-efprpk72	252	15	there	there	EX
cord-012902-efprpk72	252	16	were	be	VBD
cord-012902-efprpk72	252	17	2736	2736	CD
cord-012902-efprpk72	252	18	CV	CV	NNP
cord-012902-efprpk72	252	19	events	event	NNS
cord-012902-efprpk72	252	20	.	.	.
cord-012902-efprpk72	253	1	Whilst	whilst	IN
cord-012902-efprpk72	253	2	c	c	NN
cord-012902-efprpk72	253	3	-	-	HYPH
cord-012902-efprpk72	253	4	statistics	statistic	NNS
cord-012902-efprpk72	253	5	and	and	CC
cord-012902-efprpk72	253	6	accuracy	accuracy	NN
cord-012902-efprpk72	253	7	of	of	IN
cord-012902-efprpk72	253	8	most	most	JJS
cord-012902-efprpk72	253	9	criteria	criterion	NNS
cord-012902-efprpk72	253	10	were	be	VBD
cord-012902-efprpk72	253	11	similar	similar	JJ
cord-012902-efprpk72	253	12	,	,	,
cord-012902-efprpk72	253	13	strain	strain	NN
cord-012902-efprpk72	253	14	pattern	pattern	NN
cord-012902-efprpk72	253	15	and	and	CC
cord-012902-efprpk72	253	16	the	the	DT
cord-012902-efprpk72	253	17	Cornell	Cornell	NNP
cord-012902-efprpk72	253	18	strain	strain	NN
cord-012902-efprpk72	253	19	were	be	VBD
cord-012902-efprpk72	253	20	better	well	JJR
cord-012902-efprpk72	253	21	in	in	IN
cord-012902-efprpk72	253	22	improving	improve	VBG
cord-012902-efprpk72	253	23	the	the	DT
cord-012902-efprpk72	253	24	prediction	prediction	NN
cord-012902-efprpk72	253	25	models	model	NNS
cord-012902-efprpk72	253	26	and	and	CC
cord-012902-efprpk72	253	27	with	with	IN
cord-012902-efprpk72	253	28	a	a	DT
cord-012902-efprpk72	253	29	higher	high	JJR
cord-012902-efprpk72	253	30	strength	strength	NN
cord-012902-efprpk72	253	31	of	of	IN
cord-012902-efprpk72	253	32	association	association	NN
cord-012902-efprpk72	253	33	with	with	IN
cord-012902-efprpk72	253	34	the	the	DT
cord-012902-efprpk72	253	35	CV	cv	NN
cord-012902-efprpk72	253	36	-	-	HYPH
cord-012902-efprpk72	253	37	outcomes	outcome	NNS
cord-012902-efprpk72	253	38	(	(	-LRB-
cord-012902-efprpk72	253	39	HR	hr	NN
cord-012902-efprpk72	254	1	1.52	1.52	CD
cord-012902-efprpk72	254	2	[	[	-LRB-
cord-012902-efprpk72	254	3	95	95	CD
cord-012902-efprpk72	254	4	%	%	NN
cord-012902-efprpk72	254	5	CI	ci	NN
cord-012902-efprpk72	254	6	:	:	:
cord-012902-efprpk72	254	7	1.35	1.35	CD
cord-012902-efprpk72	254	8	-	-	SYM
cord-012902-efprpk72	254	9	1.71	1.71	CD
cord-012902-efprpk72	254	10	]	]	-RRB-
cord-012902-efprpk72	254	11	,	,	,
cord-012902-efprpk72	254	12	Z	z	NN
cord-012902-efprpk72	254	13	-	-	HYPH
cord-012902-efprpk72	254	14	statistic	statistic	NN
cord-012902-efprpk72	254	15	6.88	6.88	CD
cord-012902-efprpk72	254	16	and	and	CC
cord-012902-efprpk72	254	17	HR	hr	NN
cord-012902-efprpk72	254	18	1.37	1.37	CD
cord-012902-efprpk72	255	1	[	[	-LRB-
cord-012902-efprpk72	255	2	1.226	1.226	CD
cord-012902-efprpk72	255	3	-	-	SYM
cord-012902-efprpk72	255	4	1.519	1.519	CD
cord-012902-efprpk72	255	5	]	]	-RRB-
cord-012902-efprpk72	255	6	,	,	,
cord-012902-efprpk72	255	7	Z	z	NN
cord-012902-efprpk72	255	8	-	-	HYPH
cord-012902-efprpk72	255	9	statistic	statistic	NN
cord-012902-efprpk72	255	10	5.70	5.70	CD
cord-012902-efprpk72	255	11	,	,	,
cord-012902-efprpk72	255	12	respectively	respectively	RB
cord-012902-efprpk72	255	13	)	)	-RRB-
cord-012902-efprpk72	255	14	.	.	.
cord-012902-efprpk72	256	1	Both	both	DT
cord-012902-efprpk72	256	2	criteria	criterion	NNS
cord-012902-efprpk72	256	3	had	have	VBD
cord-012902-efprpk72	256	4	excellent	excellent	JJ
cord-012902-efprpk72	256	5	BIC	BIC	NNP
cord-012902-efprpk72	256	6	too	too	RB
cord-012902-efprpk72	256	7	.	.	.
cord-012902-efprpk72	257	1	Conclusions	conclusion	NNS
cord-012902-efprpk72	257	2	:	:	:
cord-012902-efprpk72	258	1	In	in	IN
cord-012902-efprpk72	258	2	hypertensive	hypertensive	JJ
cord-012902-efprpk72	258	3	patients	patient	NNS
cord-012902-efprpk72	258	4	,	,	,
cord-012902-efprpk72	258	5	compared	compare	VBN
cord-012902-efprpk72	258	6	to	to	IN
cord-012902-efprpk72	258	7	other	other	JJ
cord-012902-efprpk72	258	8	ECG	ECG	NNP
cord-012902-efprpk72	258	9	criteria	criterion	NNS
cord-012902-efprpk72	258	10	of	of	IN
cord-012902-efprpk72	258	11	LVH	LVH	NNP
cord-012902-efprpk72	258	12	,	,	,
cord-012902-efprpk72	258	13	strain	strain	NN
cord-012902-efprpk72	258	14	pattern	pattern	NN
cord-012902-efprpk72	258	15	and	and	CC
cord-012902-efprpk72	258	16	Cornell	Cornell	NNP
cord-012902-efprpk72	258	17	-	-	HYPH
cord-012902-efprpk72	258	18	train	train	NN
cord-012902-efprpk72	258	19	index	index	NN
cord-012902-efprpk72	258	20	are	be	VBP
cord-012902-efprpk72	258	21	stronger	strong	JJR
cord-012902-efprpk72	258	22	and	and	CC
cord-012902-efprpk72	258	23	better	well	JJR
cord-012902-efprpk72	258	24	predictor	predictor	NN
cord-012902-efprpk72	258	25	of	of	IN
cord-012902-efprpk72	258	26	the	the	DT
cord-012902-efprpk72	258	27	risk	risk	NN
cord-012902-efprpk72	258	28	of	of	IN
cord-012902-efprpk72	258	29	CV	cv	NN
cord-012902-efprpk72	258	30	-	-	HYPH
cord-012902-efprpk72	258	31	morbidity	morbidity	NN
cord-012902-efprpk72	258	32	and	and	CC
cord-012902-efprpk72	258	33	mortality	mortality	NN
cord-012902-efprpk72	258	34	.	.	.
cord-012902-efprpk72	259	1	Clinical	clinical	JJ
cord-012902-efprpk72	259	2	Trial	Trial	NNP
cord-012902-efprpk72	259	3	Registry	Registry	NNP
cord-012902-efprpk72	259	4	:	:	:
cord-012902-efprpk72	259	5	ASCOT	ASCOT	NNP
cord-012902-efprpk72	259	6	was	be	VBD
cord-012902-efprpk72	259	7	conducted	conduct	VBN
cord-012902-efprpk72	259	8	before	before	IN
cord-012902-efprpk72	259	9	trial	trial	NN
cord-012902-efprpk72	259	10	registration	registration	NN
cord-012902-efprpk72	259	11	was	be	VBD
cord-012902-efprpk72	259	12	mandatory	mandatory	JJ
cord-012902-efprpk72	259	13	,	,	,
cord-012902-efprpk72	259	14	however	however	RB
cord-012902-efprpk72	259	15	it	-PRON-	PRP
cord-012902-efprpk72	259	16	did	do	VBD
cord-012902-efprpk72	259	17	pre	pre	VB
cord-012902-efprpk72	259	18	-	-	VB
cord-012902-efprpk72	259	19	specify	specify	VB
cord-012902-efprpk72	260	1	the	the	DT
cord-012902-efprpk72	260	2	study	study	NN
cord-012902-efprpk72	260	3	design	design	NN
cord-012902-efprpk72	260	4	in	in	IN
cord-012902-efprpk72	260	5	a	a	DT
cord-012902-efprpk72	260	6	separate	separate	JJ
cord-012902-efprpk72	260	7	paper	paper	NN
cord-012902-efprpk72	260	8	(	(	-LRB-
cord-012902-efprpk72	260	9	https://doi.org/10.1097/	https://doi.org/10.1097/	NNP
cord-012902-efprpk72	260	10	00004872	00004872	CD
cord-012902-efprpk72	260	11	-	-	HYPH
cord-012902-efprpk72	260	12	200106000	200106000	CD
cord-012902-efprpk72	260	13	-	-	HYPH
cord-012902-efprpk72	260	14	00020	00020	CD
cord-012902-efprpk72	260	15	)	)	-RRB-
cord-012902-efprpk72	260	16	,	,	,
cord-012902-efprpk72	260	17	http://www.ascotstudy	http://www.ascotstudy	NNP
cord-012902-efprpk72	260	18	.	.	.
cord-012902-efprpk72	261	1	org.uk/	org.uk/	NNPS
cord-012902-efprpk72	262	1	Disclosures	disclosure	NNS
cord-012902-efprpk72	262	2	:	:	:
cord-012902-efprpk72	262	3	None	none	NN
cord-012902-efprpk72	262	4	.	.	.
cord-012902-efprpk72	263	1	Results	result	NNS
cord-012902-efprpk72	263	2	:	:	:
cord-012902-efprpk72	264	1	170	170	CD
cord-012902-efprpk72	264	2	patients	patient	NNS
cord-012902-efprpk72	264	3	were	be	VBD
cord-012902-efprpk72	264	4	assessed	assess	VBN
cord-012902-efprpk72	264	5	.	.	.
cord-012902-efprpk72	265	1	The	the	DT
cord-012902-efprpk72	265	2	mean	mean	JJ
cord-012902-efprpk72	265	3	age	age	NN
cord-012902-efprpk72	265	4	was	be	VBD
cord-012902-efprpk72	265	5	59.6	59.6	CD
cord-012902-efprpk72	265	6	±	±	NNP
cord-012902-efprpk72	265	7	9.6	9.6	CD
cord-012902-efprpk72	265	8	years	year	NNS
cord-012902-efprpk72	265	9	,	,	,
cord-012902-efprpk72	265	10	males	male	NNS
cord-012902-efprpk72	265	11	(	(	-LRB-
cord-012902-efprpk72	265	12	78	78	CD
cord-012902-efprpk72	265	13	%	%	NN
cord-012902-efprpk72	265	14	)	)	-RRB-
cord-012902-efprpk72	265	15	and	and	CC
cord-012902-efprpk72	265	16	Caucasians	Caucasians	NNPS
cord-012902-efprpk72	265	17	(	(	-LRB-
cord-012902-efprpk72	265	18	66	66	CD
cord-012902-efprpk72	265	19	%	%	NN
cord-012902-efprpk72	265	20	)	)	-RRB-
cord-012902-efprpk72	265	21	.	.	.
cord-012902-efprpk72	266	1	The	the	DT
cord-012902-efprpk72	266	2	average	average	JJ
cord-012902-efprpk72	266	3	number	number	NN
cord-012902-efprpk72	266	4	of	of	IN
cord-012902-efprpk72	266	5	anti	anti	JJ
cord-012902-efprpk72	266	6	-	-	JJ
cord-012902-efprpk72	266	7	hypertensive	hypertensive	JJ
cord-012902-efprpk72	266	8	medications	medication	NNS
cord-012902-efprpk72	266	9	was	be	VBD
cord-012902-efprpk72	266	10	4.1	4.1	CD
cord-012902-efprpk72	266	11	±	±	CD
cord-012902-efprpk72	266	12	1.2	1.2	CD
cord-012902-efprpk72	266	13	.	.	.
cord-012902-efprpk72	267	1	The	the	DT
cord-012902-efprpk72	267	2	mean	mean	JJ
cord-012902-efprpk72	267	3	CBP	CBP	NNP
cord-012902-efprpk72	267	4	was	be	VBD
cord-012902-efprpk72	267	5	154/91	154/91	CD
cord-012902-efprpk72	267	6	mmHg	mmHg	NNP
cord-012902-efprpk72	267	7	,	,	,
cord-012902-efprpk72	267	8	mean	mean	JJ
cord-012902-efprpk72	267	9	daytime	daytime	NN
cord-012902-efprpk72	267	10	ABP	ABP	NNP
cord-012902-efprpk72	267	11	was	be	VBD
cord-012902-efprpk72	267	12	150/85	150/85	CD
cord-012902-efprpk72	267	13	mmHg	mmHg	NNS
cord-012902-efprpk72	267	14	.	.	.
cord-012902-efprpk72	268	1	Following	follow	VBG
cord-012902-efprpk72	268	2	adjustments	adjustment	NNS
cord-012902-efprpk72	268	3	in	in	IN
cord-012902-efprpk72	268	4	medication	medication	NN
cord-012902-efprpk72	268	5	after	after	IN
cord-012902-efprpk72	268	6	4	4	CD
cord-012902-efprpk72	268	7	weeks	week	NNS
cord-012902-efprpk72	268	8	,	,	,
cord-012902-efprpk72	268	9	the	the	DT
cord-012902-efprpk72	268	10	reduction	reduction	NN
cord-012902-efprpk72	268	11	in	in	IN
cord-012902-efprpk72	268	12	Clinic	Clinic	NNP
cord-012902-efprpk72	268	13	SBP	SBP	NNP
cord-012902-efprpk72	268	14	was	be	VBD
cord-012902-efprpk72	269	1	14	14	CD
cord-012902-efprpk72	269	2	±	±	CD
cord-012902-efprpk72	269	3	10	10	CD
cord-012902-efprpk72	269	4	mmHg	mmHg	NNS
cord-012902-efprpk72	269	5	and	and	CC
cord-012902-efprpk72	269	6	DBP	DBP	NNP
cord-012902-efprpk72	269	7	was	be	VBD
cord-012902-efprpk72	269	8	6.3	6.3	CD
cord-012902-efprpk72	269	9	±	±	CD
cord-012902-efprpk72	269	10	6.2	6.2	CD
cord-012902-efprpk72	269	11	mmHg	mmHg	NNS
cord-012902-efprpk72	269	12	(	(	-LRB-
cord-012902-efprpk72	269	13	n	n	NN
cord-012902-efprpk72	269	14	=	=	SYM
cord-012902-efprpk72	269	15	145	145	CD
cord-012902-efprpk72	269	16	;	;	:
cord-012902-efprpk72	269	17	p	p	NN
cord-012902-efprpk72	269	18	<	<	XX
cord-012902-efprpk72	269	19	0.001	0.001	CD
cord-012902-efprpk72	269	20	for	for	IN
cord-012902-efprpk72	269	21	both	both	DT
cord-012902-efprpk72	269	22	)	)	-RRB-
cord-012902-efprpk72	269	23	.	.	.
cord-012902-efprpk72	270	1	The	the	DT
cord-012902-efprpk72	270	2	reduction	reduction	NN
cord-012902-efprpk72	270	3	in	in	IN
cord-012902-efprpk72	270	4	mean	mean	JJ
cord-012902-efprpk72	270	5	systolic	systolic	JJ
cord-012902-efprpk72	270	6	daytime	daytime	NN
cord-012902-efprpk72	270	7	ABP	ABP	NNP
cord-012902-efprpk72	270	8	was	be	VBD
cord-012902-efprpk72	271	1	8	8	CD
cord-012902-efprpk72	271	2	±	±	CD
cord-012902-efprpk72	271	3	8.2	8.2	CD
cord-012902-efprpk72	271	4	mmHg	mmHg	NNS
cord-012902-efprpk72	271	5	and	and	CC
cord-012902-efprpk72	271	6	DBP	DBP	NNP
cord-012902-efprpk72	271	7	was	be	VBD
cord-012902-efprpk72	271	8	6	6	CD
cord-012902-efprpk72	271	9	±	±	NNP
cord-012902-efprpk72	271	10	7	7	CD
cord-012902-efprpk72	271	11	mmHg	mmHg	NNPS
cord-012902-efprpk72	271	12	(	(	-LRB-
cord-012902-efprpk72	271	13	n	n	NN
cord-012902-efprpk72	271	14	=	=	SYM
cord-012902-efprpk72	271	15	91	91	CD
cord-012902-efprpk72	271	16	,	,	,
cord-012902-efprpk72	271	17	p	p	NN
cord-012902-efprpk72	271	18	<	<	XX
cord-012902-efprpk72	271	19	0.001	0.001	CD
cord-012902-efprpk72	271	20	for	for	IN
cord-012902-efprpk72	271	21	both	both	DT
cord-012902-efprpk72	271	22	)	)	-RRB-
cord-012902-efprpk72	271	23	.	.	.
cord-012902-efprpk72	272	1	The	the	DT
cord-012902-efprpk72	272	2	average	average	JJ
cord-012902-efprpk72	272	3	number	number	NN
cord-012902-efprpk72	272	4	of	of	IN
cord-012902-efprpk72	272	5	anti	anti	JJ
cord-012902-efprpk72	272	6	-	-	JJ
cord-012902-efprpk72	272	7	hypertensive	hypertensive	JJ
cord-012902-efprpk72	272	8	medications	medication	NNS
cord-012902-efprpk72	272	9	reduced	reduce	VBN
cord-012902-efprpk72	272	10	to	to	IN
cord-012902-efprpk72	272	11	3.2	3.2	CD
cord-012902-efprpk72	272	12	±	±	NNP
cord-012902-efprpk72	272	13	1.3	1.3	CD
cord-012902-efprpk72	272	14	.	.	.
cord-012902-efprpk72	273	1	Screening	screening	NN
cord-012902-efprpk72	273	2	generated	generate	VBD
cord-012902-efprpk72	273	3	74	74	CD
cord-012902-efprpk72	273	4	new	new	JJ
cord-012902-efprpk72	273	5	diagnoses	diagnosis	NNS
cord-012902-efprpk72	273	6	and	and	CC
cord-012902-efprpk72	273	7	34	34	CD
cord-012902-efprpk72	273	8	newly	newly	RB
cord-012902-efprpk72	273	9	detected	detect	VBN
cord-012902-efprpk72	273	10	cases	case	NNS
cord-012902-efprpk72	273	11	of	of	IN
cord-012902-efprpk72	273	12	secondary	secondary	JJ
cord-012902-efprpk72	273	13	hypertension	hypertension	NN
cord-012902-efprpk72	273	14	(	(	-LRB-
cord-012902-efprpk72	273	15	summarised	summarise	VBN
cord-012902-efprpk72	273	16	below	below	RB
cord-012902-efprpk72	273	17	)	)	-RRB-
cord-012902-efprpk72	273	18	.	.	.
cord-012902-efprpk72	273	19	.	.	.
cord-012902-efprpk72	274	1	We	-PRON-	PRP
cord-012902-efprpk72	274	2	performed	perform	VBD
cord-012902-efprpk72	274	3	a	a	DT
cord-012902-efprpk72	274	4	binary	binary	JJ
cord-012902-efprpk72	274	5	logistic	logistic	JJ
cord-012902-efprpk72	274	6	regression	regression	NN
cord-012902-efprpk72	274	7	for	for	IN
cord-012902-efprpk72	274	8	nonadherence	nonadherence	NN
cord-012902-efprpk72	274	9	using	use	VBG
cord-012902-efprpk72	274	10	age	age	NN
cord-012902-efprpk72	274	11	,	,	,
cord-012902-efprpk72	274	12	sex	sex	NN
cord-012902-efprpk72	274	13	,	,	,
cord-012902-efprpk72	274	14	body	body	NN
cord-012902-efprpk72	274	15	mass	mass	NN
cord-012902-efprpk72	274	16	index	index	NN
cord-012902-efprpk72	274	17	(	(	-LRB-
cord-012902-efprpk72	274	18	BMI	BMI	NNP
cord-012902-efprpk72	274	19	)	)	-RRB-
cord-012902-efprpk72	274	20	,	,	,
cord-012902-efprpk72	274	21	number	number	NN
cord-012902-efprpk72	274	22	of	of	IN
cord-012902-efprpk72	274	23	medications	medication	NNS
cord-012902-efprpk72	274	24	prescribed	prescribe	VBN
cord-012902-efprpk72	274	25	(	(	-LRB-
cord-012902-efprpk72	274	26	both	both	DT
cord-012902-efprpk72	274	27	anti	anti	JJ
cord-012902-efprpk72	274	28	-	-	JJ
cord-012902-efprpk72	274	29	hypertensives	hypertensive	NNS
cord-012902-efprpk72	274	30	and	and	CC
cord-012902-efprpk72	274	31	non	non	JJ
cord-012902-efprpk72	274	32	-	-	JJ
cord-012902-efprpk72	274	33	anti	anti	JJ
cord-012902-efprpk72	274	34	-	-	JJ
cord-012902-efprpk72	274	35	hypertensives	hypertensives	JJ
cord-012902-efprpk72	274	36	separately	separately	RB
cord-012902-efprpk72	274	37	)	)	-RRB-
cord-012902-efprpk72	274	38	,	,	,
cord-012902-efprpk72	274	39	as	as	IN
cord-012902-efprpk72	274	40	independent	independent	JJ
cord-012902-efprpk72	274	41	predictors	predictor	NNS
cord-012902-efprpk72	274	42	.	.	.
cord-012902-efprpk72	275	1	Nonadherence	Nonadherence	NNP
cord-012902-efprpk72	275	2	percentages	percentage	NNS
cord-012902-efprpk72	275	3	for	for	IN
cord-012902-efprpk72	275	4	individual	individual	JJ
cord-012902-efprpk72	275	5	medications	medication	NNS
cord-012902-efprpk72	275	6	were	be	VBD
cord-012902-efprpk72	275	7	calculated	calculate	VBN
cord-012902-efprpk72	275	8	for	for	IN
cord-012902-efprpk72	275	9	antihypertensive	antihypertensive	JJ
cord-012902-efprpk72	275	10	drugs	drug	NNS
cord-012902-efprpk72	275	11	prescribed	prescribe	VBN
cord-012902-efprpk72	275	12	to	to	IN
cord-012902-efprpk72	275	13	10	10	CD
cord-012902-efprpk72	275	14	or	or	CC
cord-012902-efprpk72	275	15	more	more	JJR
cord-012902-efprpk72	275	16	patients	patient	NNS
cord-012902-efprpk72	275	17	Results	result	NNS
cord-012902-efprpk72	275	18	:	:	:
cord-012902-efprpk72	275	19	The	the	DT
cord-012902-efprpk72	275	20	overall	overall	JJ
cord-012902-efprpk72	275	21	rate	rate	NN
cord-012902-efprpk72	275	22	of	of	IN
cord-012902-efprpk72	275	23	nonadherence	nonadherence	NN
cord-012902-efprpk72	275	24	to	to	IN
cord-012902-efprpk72	275	25	one	one	CD
cord-012902-efprpk72	275	26	or	or	CC
cord-012902-efprpk72	275	27	more	more	JJR
cord-012902-efprpk72	275	28	prescribed	prescribed	JJ
cord-012902-efprpk72	275	29	antihypertensive	antihypertensive	JJ
cord-012902-efprpk72	275	30	medications	medication	NNS
cord-012902-efprpk72	275	31	was	be	VBD
cord-012902-efprpk72	275	32	40.3	40.3	CD
cord-012902-efprpk72	275	33	%	%	NN
cord-012902-efprpk72	275	34	.	.	.
cord-012902-efprpk72	276	1	14.4	14.4	CD
cord-012902-efprpk72	276	2	%	%	NN
cord-012902-efprpk72	276	3	of	of	IN
cord-012902-efprpk72	276	4	patients	patient	NNS
cord-012902-efprpk72	276	5	were	be	VBD
cord-012902-efprpk72	276	6	nonadherent	nonadherent	JJ
cord-012902-efprpk72	276	7	to	to	IN
cord-012902-efprpk72	276	8	all	all	DT
cord-012902-efprpk72	276	9	prescribed	prescribe	VBN
cord-012902-efprpk72	276	10	antihypertensive	antihypertensive	JJ
cord-012902-efprpk72	276	11	medications	medication	NNS
cord-012902-efprpk72	276	12	(	(	-LRB-
cord-012902-efprpk72	276	13	complete	complete	JJ
cord-012902-efprpk72	276	14	nonadherence	nonadherence	NNP
cord-012902-efprpk72	276	15	)	)	-RRB-
cord-012902-efprpk72	276	16	,	,	,
cord-012902-efprpk72	276	17	whereas	whereas	IN
cord-012902-efprpk72	276	18	25.9	25.9	CD
cord-012902-efprpk72	276	19	%	%	NN
cord-012902-efprpk72	276	20	of	of	IN
cord-012902-efprpk72	276	21	patients	patient	NNS
cord-012902-efprpk72	276	22	were	be	VBD
cord-012902-efprpk72	276	23	nonadherent	nonadherent	JJ
cord-012902-efprpk72	276	24	to	to	IN
cord-012902-efprpk72	276	25	one	one	CD
cord-012902-efprpk72	276	26	or	or	CC
cord-012902-efprpk72	276	27	more	more	JJR
cord-012902-efprpk72	276	28	,	,	,
cord-012902-efprpk72	276	29	but	but	CC
cord-012902-efprpk72	276	30	not	not	RB
cord-012902-efprpk72	276	31	all	all	DT
cord-012902-efprpk72	276	32	prescribed	prescribe	VBN
cord-012902-efprpk72	276	33	antihypertensive	antihypertensive	JJ
cord-012902-efprpk72	276	34	medications	medication	NNS
cord-012902-efprpk72	276	35	(	(	-LRB-
cord-012902-efprpk72	276	36	partial	partial	JJ
cord-012902-efprpk72	276	37	nonadherence	nonadherence	NN
cord-012902-efprpk72	276	38	)	)	-RRB-
cord-012902-efprpk72	276	39	.	.	.
cord-012902-efprpk72	277	1	More	More	JJR
cord-012902-efprpk72	277	2	than	than	IN
cord-012902-efprpk72	277	3	60	60	CD
cord-012902-efprpk72	277	4	%	%	NN
cord-012902-efprpk72	277	5	of	of	IN
cord-012902-efprpk72	277	6	patients	patient	NNS
cord-012902-efprpk72	277	7	were	be	VBD
cord-012902-efprpk72	277	8	on	on	IN
cord-012902-efprpk72	277	9	at	at	RB
cord-012902-efprpk72	277	10	least	least	JJS
cord-012902-efprpk72	277	11	3	3	CD
cord-012902-efprpk72	277	12	medications	medication	NNS
cord-012902-efprpk72	277	13	for	for	IN
cord-012902-efprpk72	277	14	hypertension	hypertension	NN
cord-012902-efprpk72	277	15	management	management	NN
cord-012902-efprpk72	277	16	and	and	CC
cord-012902-efprpk72	277	17	polypharmacy	polypharmacy	JJ
cord-012902-efprpk72	277	18	(	(	-LRB-
cord-012902-efprpk72	277	19	≥6	≥6	NN
cord-012902-efprpk72	277	20	medications	medication	NNS
cord-012902-efprpk72	277	21	,	,	,
cord-012902-efprpk72	277	22	all	all	DT
cord-012902-efprpk72	277	23	indications	indication	NNS
cord-012902-efprpk72	277	24	)	)	-RRB-
cord-012902-efprpk72	277	25	was	be	VBD
cord-012902-efprpk72	277	26	prevalent	prevalent	JJ
cord-012902-efprpk72	277	27	in	in	IN
cord-012902-efprpk72	277	28	52	52	CD
cord-012902-efprpk72	277	29	%	%	NN
cord-012902-efprpk72	277	30	.	.	.
cord-012902-efprpk72	278	1	Nonadherence	Nonadherence	NNP
cord-012902-efprpk72	278	2	was	be	VBD
cord-012902-efprpk72	278	3	higher	high	JJR
cord-012902-efprpk72	278	4	in	in	IN
cord-012902-efprpk72	278	5	women	woman	NNS
cord-012902-efprpk72	278	6	compared	compare	VBN
cord-012902-efprpk72	278	7	to	to	IN
cord-012902-efprpk72	278	8	men	man	NNS
cord-012902-efprpk72	278	9	with	with	IN
cord-012902-efprpk72	278	10	adjusted	adjust	VBN
cord-012902-efprpk72	278	11	odds	odd	NNS
cord-012902-efprpk72	278	12	ratio	ratio	NN
cord-012902-efprpk72	278	13	of	of	IN
cord-012902-efprpk72	278	14	0.22	0.22	CD
cord-012902-efprpk72	278	15	(	(	-LRB-
cord-012902-efprpk72	278	16	p	p	NN
cord-012902-efprpk72	278	17	=	=	SYM
cord-012902-efprpk72	278	18	0.005	0.005	CD
cord-012902-efprpk72	278	19	,	,	,
cord-012902-efprpk72	278	20	95%CI	95%ci	CD
cord-012902-efprpk72	278	21	=	=	SYM
cord-012902-efprpk72	278	22	0.08	0.08	CD
cord-012902-efprpk72	278	23	-	-	HYPH
cord-012902-efprpk72	278	24	0.633	0.633	CD
cord-012902-efprpk72	278	25	)	)	-RRB-
cord-012902-efprpk72	278	26	,	,	,
cord-012902-efprpk72	278	27	and	and	CC
cord-012902-efprpk72	278	28	lowered	lower	VBN
cord-012902-efprpk72	278	29	with	with	IN
cord-012902-efprpk72	278	30	age	age	NN
cord-012902-efprpk72	278	31	with	with	IN
cord-012902-efprpk72	278	32	odds	odd	NNS
cord-012902-efprpk72	278	33	of	of	IN
cord-012902-efprpk72	278	34	0.958	0.958	CD
cord-012902-efprpk72	278	35	(	(	-LRB-
cord-012902-efprpk72	278	36	p	p	NN
cord-012902-efprpk72	278	37	=	=	SYM
cord-012902-efprpk72	278	38	0.02	0.02	CD
cord-012902-efprpk72	278	39	,	,	,
cord-012902-efprpk72	279	1	95	95	CD
cord-012902-efprpk72	279	2	%	%	NN
cord-012902-efprpk72	279	3	CI	ci	NN
cord-012902-efprpk72	279	4	=	=	SYM
cord-012902-efprpk72	279	5	0.925	0.925	CD
cord-012902-efprpk72	279	6	-	-	SYM
cord-012902-efprpk72	279	7	0.993	0.993	CD
cord-012902-efprpk72	279	8	)	)	-RRB-
cord-012902-efprpk72	279	9	.	.	.
cord-012902-efprpk72	280	1	For	for	IN
cord-012902-efprpk72	280	2	every	every	DT
cord-012902-efprpk72	280	3	increase	increase	NN
cord-012902-efprpk72	280	4	in	in	IN
cord-012902-efprpk72	280	5	number	number	NN
cord-012902-efprpk72	280	6	of	of	IN
cord-012902-efprpk72	280	7	anti	anti	JJ
cord-012902-efprpk72	280	8	-	-	JJ
cord-012902-efprpk72	280	9	hypertensive	hypertensive	JJ
cord-012902-efprpk72	280	10	medication	medication	NN
cord-012902-efprpk72	280	11	,	,	,
cord-012902-efprpk72	280	12	nonadherence	nonadherence	NNP
cord-012902-efprpk72	280	13	increased	increase	VBD
cord-012902-efprpk72	280	14	by	by	IN
cord-012902-efprpk72	280	15	odds	odd	NNS
cord-012902-efprpk72	280	16	of	of	IN
cord-012902-efprpk72	280	17	3.7	3.7	CD
cord-012902-efprpk72	280	18	(	(	-LRB-
cord-012902-efprpk72	280	19	p	p	NN
cord-012902-efprpk72	280	20	=	=	SYM
cord-012902-efprpk72	280	21	0.000	0.000	CD
cord-012902-efprpk72	280	22	,	,	,
cord-012902-efprpk72	280	23	95	95	CD
cord-012902-efprpk72	280	24	%	%	NN
cord-012902-efprpk72	281	1	CI	CI	NNP
cord-012902-efprpk72	281	2	=	=	SYM
cord-012902-efprpk72	281	3	2.2	2.2	CD
cord-012902-efprpk72	281	4	-	-	SYM
cord-012902-efprpk72	281	5	5.9	5.9	CD
cord-012902-efprpk72	281	6	)	)	-RRB-
cord-012902-efprpk72	281	7	and	and	CC
cord-012902-efprpk72	281	8	every	every	DT
cord-012902-efprpk72	281	9	increase	increase	NN
cord-012902-efprpk72	281	10	in	in	IN
cord-012902-efprpk72	281	11	prescription	prescription	NN
cord-012902-efprpk72	281	12	of	of	IN
cord-012902-efprpk72	281	13	nonantihypertensive	nonantihypertensive	JJ
cord-012902-efprpk72	281	14	medication	medication	NN
cord-012902-efprpk72	281	15	,	,	,
cord-012902-efprpk72	281	16	the	the	DT
cord-012902-efprpk72	281	17	odds	odd	NNS
cord-012902-efprpk72	281	18	increased	increase	VBD
cord-012902-efprpk72	281	19	by	by	IN
cord-012902-efprpk72	281	20	1.1	1.1	CD
cord-012902-efprpk72	281	21	(	(	-LRB-
cord-012902-efprpk72	281	22	p	p	NN
cord-012902-efprpk72	281	23	=	=	SYM
cord-012902-efprpk72	281	24	0.05	0.05	CD
cord-012902-efprpk72	281	25	,	,	,
cord-012902-efprpk72	281	26	95	95	CD
cord-012902-efprpk72	281	27	%	%	NN
cord-012902-efprpk72	282	1	CI	CI	NNP
cord-012902-efprpk72	282	2	=	=	SYM
cord-012902-efprpk72	282	3	0.9	0.9	CD
cord-012902-efprpk72	282	4	-	-	SYM
cord-012902-efprpk72	282	5	1.2	1.2	CD
cord-012902-efprpk72	282	6	)	)	-RRB-
cord-012902-efprpk72	282	7	.	.	.
cord-012902-efprpk72	283	1	Furosemide	Furosemide	NNP
cord-012902-efprpk72	283	2	and	and	CC
cord-012902-efprpk72	283	3	Chlortalidone	Chlortalidone	NNP
cord-012902-efprpk72	283	4	demonstrated	demonstrate	VBD
cord-012902-efprpk72	283	5	the	the	DT
cord-012902-efprpk72	283	6	highest	high	JJS
cord-012902-efprpk72	283	7	and	and	CC
cord-012902-efprpk72	283	8	lowest	low	JJS
cord-012902-efprpk72	283	9	nonadherences	nonadherence	NNS
cord-012902-efprpk72	283	10	respectively	respectively	RB
cord-012902-efprpk72	283	11	(	(	-LRB-
cord-012902-efprpk72	283	12	52.9	52.9	CD
cord-012902-efprpk72	283	13	and	and	CC
cord-012902-efprpk72	283	14	11.8	11.8	CD
cord-012902-efprpk72	283	15	%	%	NN
cord-012902-efprpk72	283	16	)	)	-RRB-
cord-012902-efprpk72	283	17	.	.	.
cord-012902-efprpk72	284	1	Conclusions	conclusion	NNS
cord-012902-efprpk72	284	2	:	:	:
cord-012902-efprpk72	285	1	Rate	rate	NN
cord-012902-efprpk72	285	2	of	of	IN
cord-012902-efprpk72	285	3	nonadherence	nonadherence	NN
cord-012902-efprpk72	285	4	in	in	IN
cord-012902-efprpk72	285	5	patients	patient	NNS
cord-012902-efprpk72	285	6	with	with	IN
cord-012902-efprpk72	285	7	uncontrolled	uncontrolled	JJ
cord-012902-efprpk72	285	8	hypertension	hypertension	NN
cord-012902-efprpk72	285	9	is	be	VBZ
cord-012902-efprpk72	285	10	significantly	significantly	RB
cord-012902-efprpk72	285	11	impacted	impact	VBN
cord-012902-efprpk72	285	12	by	by	IN
cord-012902-efprpk72	285	13	factors	factor	NNS
cord-012902-efprpk72	285	14	such	such	JJ
cord-012902-efprpk72	285	15	as	as	IN
cord-012902-efprpk72	285	16	sex	sex	NN
cord-012902-efprpk72	285	17	,	,	,
cord-012902-efprpk72	285	18	number	number	NN
cord-012902-efprpk72	285	19	of	of	IN
cord-012902-efprpk72	285	20	medications	medication	NNS
cord-012902-efprpk72	285	21	prescribed	prescribe	VBN
cord-012902-efprpk72	285	22	for	for	IN
cord-012902-efprpk72	285	23	hypertension	hypertension	NN
cord-012902-efprpk72	285	24	and	and	CC
cord-012902-efprpk72	285	25	polypharmacy	polypharmacy	NN
cord-012902-efprpk72	285	26	.	.	.
cord-012902-efprpk72	286	1	Understanding	understanding	NN
cord-012902-efprpk72	286	2	factors	factor	NNS
cord-012902-efprpk72	286	3	which	which	WDT
cord-012902-efprpk72	286	4	affect	affect	VBP
cord-012902-efprpk72	286	5	compliance	compliance	NN
cord-012902-efprpk72	286	6	is	be	VBZ
cord-012902-efprpk72	286	7	crucial	crucial	JJ
cord-012902-efprpk72	286	8	in	in	IN
cord-012902-efprpk72	286	9	identifying	identify	VBG
cord-012902-efprpk72	286	10	and	and	CC
cord-012902-efprpk72	286	11	target	target	VB
cord-012902-efprpk72	286	12	interventions	intervention	NNS
cord-012902-efprpk72	286	13	better	well	RBR
cord-012902-efprpk72	286	14	.	.	.
cord-012902-efprpk72	287	1	P-07	P-07	NNP
cord-012902-efprpk72	287	2	Blood	blood	NN
cord-012902-efprpk72	287	3	pressure	pressure	NN
cord-012902-efprpk72	287	4	drug	drug	NN
cord-012902-efprpk72	287	5	adherence	adherence	NN
cord-012902-efprpk72	287	6	screening	screening	NN
cord-012902-efprpk72	287	7	in	in	IN
cord-012902-efprpk72	287	8	an	an	DT
cord-012902-efprpk72	287	9	elderly	elderly	JJ
cord-012902-efprpk72	287	10	primary	primary	JJ
cord-012902-efprpk72	287	11	care	care	NN
cord-012902-efprpk72	287	12	population	population	NN
cord-012902-efprpk72	287	13	-	-	:
cord-012902-efprpk72	287	14	the	the	DT
cord-012902-efprpk72	287	15	BPD	BPD	NNP
cord-012902-efprpk72	287	16	-	-	HYPH
cord-012902-efprpk72	287	17	Screen	screen	NN
cord-012902-efprpk72	287	18	feasibility	feasibility	NN
cord-012902-efprpk72	287	19	study	study	NN
cord-012902-efprpk72	287	20	Introduction	introduction	NN
cord-012902-efprpk72	287	21	:	:	:
cord-012902-efprpk72	288	1	To	to	TO
cord-012902-efprpk72	288	2	assess	assess	VB
cord-012902-efprpk72	288	3	the	the	DT
cord-012902-efprpk72	288	4	feasibility	feasibility	NN
cord-012902-efprpk72	288	5	of	of	IN
cord-012902-efprpk72	288	6	collecting	collect	VBG
cord-012902-efprpk72	288	7	urine	urine	NN
cord-012902-efprpk72	288	8	samples	sample	NNS
cord-012902-efprpk72	288	9	from	from	IN
cord-012902-efprpk72	288	10	elderly	elderly	JJ
cord-012902-efprpk72	288	11	hypertensive	hypertensive	JJ
cord-012902-efprpk72	288	12	patients	patient	NNS
cord-012902-efprpk72	288	13	to	to	TO
cord-012902-efprpk72	288	14	check	check	VB
cord-012902-efprpk72	288	15	for	for	IN
cord-012902-efprpk72	288	16	antihypertensive	antihypertensive	JJ
cord-012902-efprpk72	288	17	drug	drug	NN
cord-012902-efprpk72	288	18	metabolites	metabolite	NNS
cord-012902-efprpk72	288	19	,	,	,
cord-012902-efprpk72	288	20	and	and	CC
cord-012902-efprpk72	288	21	hence	hence	RB
cord-012902-efprpk72	288	22	adherence	adherence	NN
cord-012902-efprpk72	288	23	to	to	IN
cord-012902-efprpk72	288	24	blood	blood	NN
cord-012902-efprpk72	288	25	pressure	pressure	NN
cord-012902-efprpk72	288	26	(	(	-LRB-
cord-012902-efprpk72	288	27	BP	BP	NNP
cord-012902-efprpk72	288	28	)	)	-RRB-
cord-012902-efprpk72	288	29	lowering	lower	VBG
cord-012902-efprpk72	288	30	therapy	therapy	NN
cord-012902-efprpk72	288	31	.	.	.
cord-012902-efprpk72	289	1	Methods	method	NNS
cord-012902-efprpk72	289	2	:	:	:
cord-012902-efprpk72	290	1	A	a	DT
cord-012902-efprpk72	290	2	multicentre	multicentre	NNP
cord-012902-efprpk72	290	3	observational	observational	JJ
cord-012902-efprpk72	290	4	cohort	cohort	NN
cord-012902-efprpk72	290	5	study	study	NN
cord-012902-efprpk72	290	6	.	.	.
cord-012902-efprpk72	291	1	Patients	patient	NNS
cord-012902-efprpk72	291	2	taking	take	VBG
cord-012902-efprpk72	291	3	at	at	RB
cord-012902-efprpk72	291	4	least	least	RBS
cord-012902-efprpk72	291	5	one	one	CD
cord-012902-efprpk72	291	6	antihypertensive	antihypertensive	JJ
cord-012902-efprpk72	291	7	medication	medication	NN
cord-012902-efprpk72	291	8	were	be	VBD
cord-012902-efprpk72	291	9	approached	approach	VBN
cord-012902-efprpk72	291	10	opportunistically	opportunistically	RB
cord-012902-efprpk72	291	11	by	by	IN
cord-012902-efprpk72	291	12	their	-PRON-	PRP$
cord-012902-efprpk72	291	13	primary	primary	JJ
cord-012902-efprpk72	291	14	care	care	NN
cord-012902-efprpk72	291	15	clinician	clinician	NN
cord-012902-efprpk72	291	16	at	at	IN
cord-012902-efprpk72	291	17	the	the	DT
cord-012902-efprpk72	291	18	end	end	NN
cord-012902-efprpk72	291	19	of	of	IN
cord-012902-efprpk72	291	20	a	a	DT
cord-012902-efprpk72	291	21	routine	routine	JJ
cord-012902-efprpk72	291	22	consultation	consultation	NN
cord-012902-efprpk72	291	23	over	over	IN
cord-012902-efprpk72	291	24	a	a	DT
cord-012902-efprpk72	291	25	5	5	CD
cord-012902-efprpk72	291	26	month	month	NN
cord-012902-efprpk72	291	27	period	period	NN
cord-012902-efprpk72	291	28	in	in	IN
cord-012902-efprpk72	291	29	2019	2019	CD
cord-012902-efprpk72	291	30	.	.	.
cord-012902-efprpk72	292	1	A	a	DT
cord-012902-efprpk72	292	2	research	research	NN
cord-012902-efprpk72	292	3	nurse	nurse	NN
cord-012902-efprpk72	292	4	undertook	undertake	VBD
cord-012902-efprpk72	292	5	the	the	DT
cord-012902-efprpk72	292	6	consenting	consenting	NN
cord-012902-efprpk72	292	7	process	process	NN
cord-012902-efprpk72	292	8	at	at	IN
cord-012902-efprpk72	292	9	each	each	DT
cord-012902-efprpk72	292	10	of	of	IN
cord-012902-efprpk72	292	11	the	the	DT
cord-012902-efprpk72	292	12	five	five	CD
cord-012902-efprpk72	292	13	general	general	JJ
cord-012902-efprpk72	292	14	practice	practice	NN
cord-012902-efprpk72	292	15	sites	site	NNS
cord-012902-efprpk72	292	16	recruited	recruit	VBN
cord-012902-efprpk72	292	17	.	.	.
cord-012902-efprpk72	293	1	The	the	DT
cord-012902-efprpk72	293	2	primary	primary	JJ
cord-012902-efprpk72	293	3	outcome	outcome	NN
cord-012902-efprpk72	293	4	was	be	VBD
cord-012902-efprpk72	293	5	the	the	DT
cord-012902-efprpk72	293	6	proportion	proportion	NN
cord-012902-efprpk72	293	7	of	of	IN
cord-012902-efprpk72	293	8	patients	patient	NNS
cord-012902-efprpk72	293	9	approached	approach	VBN
cord-012902-efprpk72	293	10	who	who	WP
cord-012902-efprpk72	293	11	consented	consent	VBD
cord-012902-efprpk72	293	12	and	and	CC
cord-012902-efprpk72	293	13	provided	provide	VBD
cord-012902-efprpk72	293	14	a	a	DT
cord-012902-efprpk72	293	15	urine	urine	NN
cord-012902-efprpk72	293	16	sample	sample	NN
cord-012902-efprpk72	293	17	.	.	.
cord-012902-efprpk72	294	1	Secondary	secondary	JJ
cord-012902-efprpk72	294	2	outcomes	outcome	NNS
cord-012902-efprpk72	294	3	were	be	VBD
cord-012902-efprpk72	294	4	the	the	DT
cord-012902-efprpk72	294	5	proportion	proportion	NN
cord-012902-efprpk72	294	6	of	of	IN
cord-012902-efprpk72	294	7	patients	patient	NNS
cord-012902-efprpk72	294	8	classified	classify	VBN
cord-012902-efprpk72	294	9	as	as	IN
cord-012902-efprpk72	294	10	adherent	adherent	JJ
cord-012902-efprpk72	294	11	(	(	-LRB-
cord-012902-efprpk72	294	12	with	with	IN
cord-012902-efprpk72	294	13	evidence	evidence	NN
cord-012902-efprpk72	294	14	of	of	IN
cord-012902-efprpk72	294	15	all	all	DT
cord-012902-efprpk72	294	16	prescribed	prescribe	VBN
cord-012902-efprpk72	294	17	antihypertensive	antihypertensive	JJ
cord-012902-efprpk72	294	18	medications	medication	NNS
cord-012902-efprpk72	294	19	in	in	IN
cord-012902-efprpk72	294	20	their	-PRON-	PRP$
cord-012902-efprpk72	294	21	urine	urine	NN
cord-012902-efprpk72	294	22	)	)	-RRB-
cord-012902-efprpk72	294	23	,	,	,
cord-012902-efprpk72	294	24	and	and	CC
cord-012902-efprpk72	294	25	to	to	TO
cord-012902-efprpk72	294	26	establish	establish	VB
cord-012902-efprpk72	294	27	medication	medication	NN
cord-012902-efprpk72	294	28	or	or	CC
cord-012902-efprpk72	294	29	demographic	demographic	JJ
cord-012902-efprpk72	294	30	factors	factor	NNS
cord-012902-efprpk72	294	31	that	that	WDT
cord-012902-efprpk72	294	32	may	may	MD
cord-012902-efprpk72	294	33	predict	predict	VB
cord-012902-efprpk72	294	34	nonadherence	nonadherence	NN
cord-012902-efprpk72	294	35	.	.	.
cord-012902-efprpk72	295	1	Baseline	baseline	JJ
cord-012902-efprpk72	295	2	medical	medical	JJ
cord-012902-efprpk72	295	3	and	and	CC
cord-012902-efprpk72	295	4	demographic	demographic	JJ
cord-012902-efprpk72	295	5	details	detail	NNS
cord-012902-efprpk72	295	6	were	be	VBD
cord-012902-efprpk72	295	7	captured	capture	VBN
cord-012902-efprpk72	295	8	from	from	IN
cord-012902-efprpk72	295	9	the	the	DT
cord-012902-efprpk72	295	10	patient	patient	NN
cord-012902-efprpk72	295	11	's	's	POS
cord-012902-efprpk72	295	12	health	health	NN
cord-012902-efprpk72	295	13	records	record	NNS
cord-012902-efprpk72	295	14	in	in	IN
cord-012902-efprpk72	295	15	both	both	DT
cord-012902-efprpk72	295	16	consenting	consent	VBG
cord-012902-efprpk72	295	17	and	and	CC
cord-012902-efprpk72	295	18	non	non	JJ
cord-012902-efprpk72	295	19	-	-	JJ
cord-012902-efprpk72	295	20	consenting	consenting	JJ
cord-012902-efprpk72	295	21	cohorts	cohort	NNS
cord-012902-efprpk72	295	22	(	(	-LRB-
cord-012902-efprpk72	295	23	anonymously	anonymously	RB
cord-012902-efprpk72	295	24	)	)	-RRB-
cord-012902-efprpk72	295	25	in	in	IN
cord-012902-efprpk72	295	26	order	order	NN
cord-012902-efprpk72	295	27	to	to	TO
cord-012902-efprpk72	295	28	compare	compare	VB
cord-012902-efprpk72	295	29	characteristics	characteristic	NNS
cord-012902-efprpk72	295	30	that	that	WDT
cord-012902-efprpk72	295	31	may	may	MD
cord-012902-efprpk72	295	32	indicate	indicate	VB
cord-012902-efprpk72	295	33	non	non	JJ
cord-012902-efprpk72	295	34	-	-	JJ
cord-012902-efprpk72	295	35	adherence	adherence	JJ
cord-012902-efprpk72	295	36	or	or	CC
cord-012902-efprpk72	295	37	nonparticipation	nonparticipation	NN
cord-012902-efprpk72	295	38	in	in	IN
cord-012902-efprpk72	295	39	an	an	DT
cord-012902-efprpk72	295	40	adherence	adherence	NN
cord-012902-efprpk72	295	41	study	study	NN
cord-012902-efprpk72	295	42	.	.	.
cord-012902-efprpk72	296	1	Results	result	NNS
cord-012902-efprpk72	296	2	:	:	:
cord-012902-efprpk72	297	1	In	in	IN
cord-012902-efprpk72	297	2	total	total	NN
cord-012902-efprpk72	297	3	,	,	,
cord-012902-efprpk72	297	4	we	-PRON-	PRP
cord-012902-efprpk72	297	5	approached	approach	VBD
cord-012902-efprpk72	297	6	351	351	CD
cord-012902-efprpk72	297	7	patients	patient	NNS
cord-012902-efprpk72	297	8	across	across	IN
cord-012902-efprpk72	297	9	five	five	CD
cord-012902-efprpk72	297	10	primary	primary	JJ
cord-012902-efprpk72	297	11	care	care	NN
cord-012902-efprpk72	297	12	centres	centre	NNS
cord-012902-efprpk72	297	13	in	in	IN
cord-012902-efprpk72	298	1	England-216	england-216	NN
cord-012902-efprpk72	298	2	patients	patient	NNS
cord-012902-efprpk72	298	3	consented	consent	VBD
cord-012902-efprpk72	298	4	to	to	IN
cord-012902-efprpk72	298	5	the	the	DT
cord-012902-efprpk72	298	6	study	study	NN
cord-012902-efprpk72	298	7	(	(	-LRB-
cord-012902-efprpk72	298	8	61.5	61.5	CD
cord-012902-efprpk72	298	9	%	%	NN
cord-012902-efprpk72	298	10	)	)	-RRB-
cord-012902-efprpk72	298	11	,	,	,
cord-012902-efprpk72	298	12	196	196	CD
cord-012902-efprpk72	298	13	of	of	IN
cord-012902-efprpk72	298	14	which	which	WDT
cord-012902-efprpk72	298	15	were	be	VBD
cord-012902-efprpk72	298	16	able	able	JJ
cord-012902-efprpk72	298	17	to	to	TO
cord-012902-efprpk72	298	18	produce	produce	VB
cord-012902-efprpk72	298	19	a	a	DT
cord-012902-efprpk72	298	20	urine	urine	NN
cord-012902-efprpk72	298	21	sample	sample	NN
cord-012902-efprpk72	298	22	at	at	IN
cord-012902-efprpk72	298	23	the	the	DT
cord-012902-efprpk72	298	24	time	time	NN
cord-012902-efprpk72	298	25	of	of	IN
cord-012902-efprpk72	298	26	recruitment	recruitment	NN
cord-012902-efprpk72	298	27	.	.	.
cord-012902-efprpk72	299	1	Mean	mean	JJ
cord-012902-efprpk72	299	2	patient	patient	JJ
cord-012902-efprpk72	299	3	age	age	NN
cord-012902-efprpk72	299	4	was	be	VBD
cord-012902-efprpk72	299	5	76.5	76.5	CD
cord-012902-efprpk72	299	6	years	year	NNS
cord-012902-efprpk72	299	7	(	(	-LRB-
cord-012902-efprpk72	299	8	49	49	CD
cord-012902-efprpk72	299	9	%	%	NN
cord-012902-efprpk72	299	10	male	male	NN
cord-012902-efprpk72	299	11	)	)	-RRB-
cord-012902-efprpk72	299	12	with	with	IN
cord-012902-efprpk72	299	13	a	a	DT
cord-012902-efprpk72	299	14	BP	BP	NNP
cord-012902-efprpk72	299	15	of	of	IN
cord-012902-efprpk72	299	16	134.5/74.9	134.5/74.9	CD
cord-012902-efprpk72	299	17	mmHg	mmHg	NNS
cord-012902-efprpk72	299	18	.	.	.
cord-012902-efprpk72	300	1	Of	of	IN
cord-012902-efprpk72	300	2	the	the	DT
cord-012902-efprpk72	300	3	369	369	CD
cord-012902-efprpk72	300	4	BP	BP	NNP
cord-012902-efprpk72	300	5	lowering	lower	VBG
cord-012902-efprpk72	300	6	medications	medication	NNS
cord-012902-efprpk72	300	7	prescribed	prescribe	VBN
cord-012902-efprpk72	300	8	(	(	-LRB-
cord-012902-efprpk72	300	9	mean	mean	NN
cord-012902-efprpk72	300	10	of	of	IN
cord-012902-efprpk72	300	11	1.9	1.9	CD
cord-012902-efprpk72	300	12	medications	medication	NNS
cord-012902-efprpk72	300	13	per	per	IN
cord-012902-efprpk72	300	14	patient	patient	NN
cord-012902-efprpk72	300	15	)	)	-RRB-
cord-012902-efprpk72	300	16	95.7	95.7	CD
cord-012902-efprpk72	300	17	%	%	NN
cord-012902-efprpk72	300	18	were	be	VBD
cord-012902-efprpk72	300	19	detected	detect	VBN
cord-012902-efprpk72	300	20	in	in	IN
cord-012902-efprpk72	300	21	the	the	DT
cord-012902-efprpk72	300	22	patient	patient	NN
cord-012902-efprpk72	300	23	's	's	POS
cord-012902-efprpk72	300	24	urine	urine	NN
cord-012902-efprpk72	300	25	.	.	.
cord-012902-efprpk72	301	1	Conclusions	conclusion	NNS
cord-012902-efprpk72	301	2	:	:	:
cord-012902-efprpk72	302	1	Opportunistic	opportunistic	JJ
cord-012902-efprpk72	302	2	screening	screening	NN
cord-012902-efprpk72	302	3	of	of	IN
cord-012902-efprpk72	302	4	antihypertensive	antihypertensive	JJ
cord-012902-efprpk72	302	5	medications	medication	NNS
cord-012902-efprpk72	302	6	was	be	VBD
cord-012902-efprpk72	302	7	feasible	feasible	JJ
cord-012902-efprpk72	302	8	in	in	IN
cord-012902-efprpk72	302	9	almost	almost	RB
cord-012902-efprpk72	302	10	2/3	2/3	CD
cord-012902-efprpk72	302	11	of	of	IN
cord-012902-efprpk72	302	12	patients	patient	NNS
cord-012902-efprpk72	302	13	approached	approach	VBN
cord-012902-efprpk72	302	14	.	.	.
cord-012902-efprpk72	303	1	Given	give	VBN
cord-012902-efprpk72	303	2	the	the	DT
cord-012902-efprpk72	303	3	potential	potential	NN
cord-012902-efprpk72	303	4	for	for	IN
cord-012902-efprpk72	303	5	non	non	JJ
cord-012902-efprpk72	303	6	-	-	JJ
cord-012902-efprpk72	303	7	adherence	adherence	NN
cord-012902-efprpk72	303	8	to	to	IN
cord-012902-efprpk72	303	9	antihypertensive	antihypertensive	JJ
cord-012902-efprpk72	303	10	medications	medication	NNS
cord-012902-efprpk72	303	11	to	to	TO
cord-012902-efprpk72	303	12	lead	lead	VB
cord-012902-efprpk72	303	13	to	to	IN
cord-012902-efprpk72	303	14	costly	costly	JJ
cord-012902-efprpk72	303	15	secondary	secondary	JJ
cord-012902-efprpk72	303	16	care	care	NN
cord-012902-efprpk72	303	17	referrals	referral	NNS
cord-012902-efprpk72	303	18	for	for	IN
cord-012902-efprpk72	303	19	so	so	RB
cord-012902-efprpk72	303	20	-	-	HYPH
cord-012902-efprpk72	303	21	called	call	VBN
cord-012902-efprpk72	303	22	pseudo	pseudo	JJ
cord-012902-efprpk72	303	23	-	-	JJ
cord-012902-efprpk72	303	24	resistant	resistant	JJ
cord-012902-efprpk72	303	25	hypertension	hypertension	NN
cord-012902-efprpk72	303	26	,	,	,
cord-012902-efprpk72	303	27	the	the	DT
cord-012902-efprpk72	303	28	ability	ability	NN
cord-012902-efprpk72	303	29	to	to	TO
cord-012902-efprpk72	303	30	objectively	objectively	RB
cord-012902-efprpk72	303	31	detect	detect	VB
cord-012902-efprpk72	303	32	non	non	JJ
cord-012902-efprpk72	303	33	-	-	JJ
cord-012902-efprpk72	303	34	adherence	adherence	NN
cord-012902-efprpk72	303	35	using	use	VBG
cord-012902-efprpk72	303	36	a	a	DT
cord-012902-efprpk72	303	37	routine	routine	JJ
cord-012902-efprpk72	303	38	urine	urine	NN
cord-012902-efprpk72	303	39	sample	sample	NN
cord-012902-efprpk72	303	40	has	have	VBZ
cord-012902-efprpk72	303	41	the	the	DT
cord-012902-efprpk72	303	42	potential	potential	NN
cord-012902-efprpk72	303	43	to	to	TO
cord-012902-efprpk72	303	44	reduce	reduce	VB
cord-012902-efprpk72	303	45	this	this	DT
cord-012902-efprpk72	303	46	.	.	.
cord-012902-efprpk72	304	1	P-08	P-08	NNP
cord-012902-efprpk72	305	1	Harms	harm	NNS
cord-012902-efprpk72	305	2	of	of	IN
cord-012902-efprpk72	305	3	antihypertensive	antihypertensive	JJ
cord-012902-efprpk72	305	4	therapy	therapy	NN
cord-012902-efprpk72	305	5	for	for	IN
cord-012902-efprpk72	305	6	hypertension	hypertension	NN
cord-012902-efprpk72	305	7	:	:	:
cord-012902-efprpk72	305	8	a	a	DT
cord-012902-efprpk72	305	9	systematic	systematic	JJ
cord-012902-efprpk72	305	10	review	review	NN
cord-012902-efprpk72	305	11	and	and	CC
cord-012902-efprpk72	305	12	meta	meta	NNP
cord-012902-efprpk72	305	13	-	-	HYPH
cord-012902-efprpk72	305	14	analysis	analysis	NN
cord-012902-efprpk72	305	15	Introduction	introduction	NN
cord-012902-efprpk72	305	16	:	:	:
cord-012902-efprpk72	305	17	The	the	DT
cord-012902-efprpk72	305	18	benefits	benefit	NNS
cord-012902-efprpk72	305	19	of	of	IN
cord-012902-efprpk72	305	20	prescribing	prescribe	VBG
cord-012902-efprpk72	305	21	antihypertensive	antihypertensive	JJ
cord-012902-efprpk72	305	22	therapy	therapy	NN
cord-012902-efprpk72	305	23	must	must	MD
cord-012902-efprpk72	305	24	be	be	VB
cord-012902-efprpk72	305	25	balanced	balance	VBN
cord-012902-efprpk72	305	26	against	against	IN
cord-012902-efprpk72	305	27	their	-PRON-	PRP$
cord-012902-efprpk72	305	28	potential	potential	JJ
cord-012902-efprpk72	305	29	harms	harm	NNS
cord-012902-efprpk72	305	30	.	.	.
cord-012902-efprpk72	306	1	Currently	currently	RB
cord-012902-efprpk72	306	2	there	there	EX
cord-012902-efprpk72	306	3	is	be	VBZ
cord-012902-efprpk72	306	4	no	no	DT
cord-012902-efprpk72	306	5	systematic	systematic	JJ
cord-012902-efprpk72	306	6	review	review	NN
cord-012902-efprpk72	306	7	quantifying	quantify	VBG
cord-012902-efprpk72	306	8	the	the	DT
cord-012902-efprpk72	306	9	extent	extent	NN
cord-012902-efprpk72	306	10	to	to	TO
cord-012902-efprpk72	306	11	which	which	WDT
cord-012902-efprpk72	306	12	antihypertensive	antihypertensive	JJ
cord-012902-efprpk72	306	13	therapy	therapy	NN
cord-012902-efprpk72	306	14	is	be	VBZ
cord-012902-efprpk72	306	15	associated	associate	VBN
cord-012902-efprpk72	306	16	with	with	IN
cord-012902-efprpk72	306	17	adverse	adverse	JJ
cord-012902-efprpk72	306	18	events	event	NNS
cord-012902-efprpk72	306	19	(	(	-LRB-
cord-012902-efprpk72	306	20	AE	AE	NNP
cord-012902-efprpk72	306	21	)	)	-RRB-
cord-012902-efprpk72	306	22	.	.	.
cord-012902-efprpk72	307	1	This	this	DT
cord-012902-efprpk72	307	2	study	study	NN
cord-012902-efprpk72	307	3	aimed	aim	VBD
cord-012902-efprpk72	307	4	to	to	TO
cord-012902-efprpk72	307	5	conduct	conduct	VB
cord-012902-efprpk72	307	6	such	such	PDT
cord-012902-efprpk72	307	7	a	a	DT
cord-012902-efprpk72	307	8	review	review	NN
cord-012902-efprpk72	307	9	using	use	VBG
cord-012902-efprpk72	307	10	data	datum	NNS
cord-012902-efprpk72	307	11	from	from	IN
cord-012902-efprpk72	307	12	previous	previous	JJ
cord-012902-efprpk72	307	13	trials	trial	NNS
cord-012902-efprpk72	307	14	.	.	.
cord-012902-efprpk72	308	1	Methods	method	NNS
cord-012902-efprpk72	308	2	:	:	:
cord-012902-efprpk72	309	1	A	a	DT
cord-012902-efprpk72	309	2	systematic	systematic	JJ
cord-012902-efprpk72	309	3	review	review	NN
cord-012902-efprpk72	309	4	and	and	CC
cord-012902-efprpk72	309	5	meta	meta	NNP
cord-012902-efprpk72	309	6	-	-	HYPH
cord-012902-efprpk72	309	7	analysis	analysis	NN
cord-012902-efprpk72	309	8	of	of	IN
cord-012902-efprpk72	309	9	randomised	randomised	JJ
cord-012902-efprpk72	309	10	controlled	control	VBN
cord-012902-efprpk72	309	11	trials	trial	NNS
cord-012902-efprpk72	309	12	(	(	-LRB-
cord-012902-efprpk72	309	13	RCTs	RCTs	NNP
cord-012902-efprpk72	309	14	)	)	-RRB-
cord-012902-efprpk72	309	15	was	be	VBD
cord-012902-efprpk72	309	16	conducted	conduct	VBN
cord-012902-efprpk72	309	17	.	.	.
cord-012902-efprpk72	310	1	A	a	DT
cord-012902-efprpk72	310	2	search	search	NN
cord-012902-efprpk72	310	3	strategy	strategy	NN
cord-012902-efprpk72	310	4	was	be	VBD
cord-012902-efprpk72	310	5	run	run	VBN
cord-012902-efprpk72	310	6	in	in	IN
cord-012902-efprpk72	310	7	five	five	CD
cord-012902-efprpk72	310	8	databases	database	NNS
cord-012902-efprpk72	310	9	.	.	.
cord-012902-efprpk72	311	1	Trials	trial	NNS
cord-012902-efprpk72	311	2	were	be	VBD
cord-012902-efprpk72	311	3	included	include	VBN
cord-012902-efprpk72	311	4	if	if	IN
cord-012902-efprpk72	311	5	they	-PRON-	PRP
cord-012902-efprpk72	311	6	examined	examine	VBD
cord-012902-efprpk72	311	7	an	an	DT
cord-012902-efprpk72	311	8	antihypertensive	antihypertensive	NN
cord-012902-efprpk72	311	9	vs	vs	IN
cord-012902-efprpk72	311	10	placebo	placebo	NN
cord-012902-efprpk72	311	11	,	,	,
cord-012902-efprpk72	311	12	more	more	JJR
cord-012902-efprpk72	311	13	vs	vs	IN
cord-012902-efprpk72	311	14	less	less	RBR
cord-012902-efprpk72	311	15	-	-	HYPH
cord-012902-efprpk72	311	16	intense	intense	JJ
cord-012902-efprpk72	311	17	treatment	treatment	NN
cord-012902-efprpk72	311	18	or	or	CC
cord-012902-efprpk72	311	19	higher	high	JJR
cord-012902-efprpk72	311	20	vs	vs	IN
cord-012902-efprpk72	311	21	lower	low	JJR
cord-012902-efprpk72	311	22	BP	BP	NNP
cord-012902-efprpk72	311	23	targets	target	NNS
cord-012902-efprpk72	311	24	and	and	CC
cord-012902-efprpk72	311	25	reported	report	VBD
cord-012902-efprpk72	311	26	50	50	CD
cord-012902-efprpk72	311	27	outcome	outcome	NN
cord-012902-efprpk72	311	28	events	event	NNS
cord-012902-efprpk72	311	29	or	or	CC
cord-012902-efprpk72	311	30	≥650	≥650	JJ
cord-012902-efprpk72	311	31	patient	patient	NN
cord-012902-efprpk72	311	32	-	-	HYPH
cord-012902-efprpk72	311	33	years	year	NNS
cord-012902-efprpk72	311	34	of	of	IN
cord-012902-efprpk72	311	35	follow	follow	NN
cord-012902-efprpk72	311	36	-	-	HYPH
cord-012902-efprpk72	311	37	up	up	NN
cord-012902-efprpk72	311	38	.	.	.
cord-012902-efprpk72	312	1	Data	datum	NNS
cord-012902-efprpk72	312	2	relating	relate	VBG
cord-012902-efprpk72	312	3	to	to	TO
cord-012902-efprpk72	312	4	study	study	VB
cord-012902-efprpk72	312	5	characteristics	characteristic	NNS
cord-012902-efprpk72	312	6	and	and	CC
cord-012902-efprpk72	312	7	outcomes	outcome	NNS
cord-012902-efprpk72	312	8	including	include	VBG
cord-012902-efprpk72	312	9	falls	fall	VBZ
cord-012902-efprpk72	312	10	(	(	-LRB-
cord-012902-efprpk72	312	11	primary	primary	JJ
cord-012902-efprpk72	312	12	outcome	outcome	NN
cord-012902-efprpk72	312	13	)	)	-RRB-
cord-012902-efprpk72	312	14	,	,	.
cord-012902-efprpk72	313	1	hypotension	hypotension	NN
cord-012902-efprpk72	313	2	,	,	,
cord-012902-efprpk72	313	3	hypo	hypo	NN
cord-012902-efprpk72	313	4	/	/	SYM
cord-012902-efprpk72	313	5	hyper	hyper	JJ
cord-012902-efprpk72	313	6	kalemia	kalemia	NN
cord-012902-efprpk72	313	7	,	,	,
cord-012902-efprpk72	313	8	syncope	syncope	NN
cord-012902-efprpk72	313	9	,	,	,
cord-012902-efprpk72	313	10	fractures	fracture	NNS
cord-012902-efprpk72	313	11	,	,	,
cord-012902-efprpk72	313	12	and	and	CC
cord-012902-efprpk72	313	13	acute	acute	JJ
cord-012902-efprpk72	313	14	kidney	kidney	NN
cord-012902-efprpk72	313	15	injury	injury	NN
cord-012902-efprpk72	313	16	(	(	-LRB-
cord-012902-efprpk72	313	17	AKI	AKI	NNP
cord-012902-efprpk72	313	18	)	)	-RRB-
cord-012902-efprpk72	313	19	were	be	VBD
cord-012902-efprpk72	313	20	extracted	extract	VBN
cord-012902-efprpk72	313	21	.	.	.
cord-012902-efprpk72	314	1	Study	study	NN
cord-012902-efprpk72	314	2	quality	quality	NN
cord-012902-efprpk72	314	3	was	be	VBD
cord-012902-efprpk72	314	4	determined	determine	VBN
cord-012902-efprpk72	314	5	using	use	VBG
cord-012902-efprpk72	314	6	the	the	DT
cord-012902-efprpk72	314	7	Cochrane	Cochrane	NNP
cord-012902-efprpk72	314	8	Risk	Risk	NNP
cord-012902-efprpk72	314	9	of	of	IN
cord-012902-efprpk72	314	10	Bias	Bias	NNP
cord-012902-efprpk72	314	11	tool	tool	NN
cord-012902-efprpk72	314	12	.	.	.
cord-012902-efprpk72	315	1	The	the	DT
cord-012902-efprpk72	315	2	association	association	NN
cord-012902-efprpk72	315	3	between	between	IN
cord-012902-efprpk72	315	4	treatment	treatment	NN
cord-012902-efprpk72	315	5	and	and	CC
cord-012902-efprpk72	315	6	outcomes	outcome	NNS
cord-012902-efprpk72	315	7	was	be	VBD
cord-012902-efprpk72	315	8	examined	examine	VBN
cord-012902-efprpk72	315	9	in	in	IN
cord-012902-efprpk72	315	10	a	a	DT
cord-012902-efprpk72	315	11	random	random	JJ
cord-012902-efprpk72	315	12	effects	effect	NNS
cord-012902-efprpk72	315	13	meta	meta	NN
cord-012902-efprpk72	315	14	-	-	HYPH
cord-012902-efprpk72	315	15	analysis	analysis	NN
cord-012902-efprpk72	315	16	.	.	.
cord-012902-efprpk72	316	1	Results	result	NNS
cord-012902-efprpk72	316	2	:	:	:
cord-012902-efprpk72	317	1	Sixty	sixty	CD
cord-012902-efprpk72	317	2	-	-	HYPH
cord-012902-efprpk72	317	3	one	one	CD
cord-012902-efprpk72	317	4	trials	trial	NNS
cord-012902-efprpk72	317	5	were	be	VBD
cord-012902-efprpk72	317	6	identified	identify	VBN
cord-012902-efprpk72	317	7	and	and	CC
cord-012902-efprpk72	317	8	included	include	VBN
cord-012902-efprpk72	317	9	in	in	IN
cord-012902-efprpk72	317	10	the	the	DT
cord-012902-efprpk72	317	11	analyses	analysis	NNS
cord-012902-efprpk72	317	12	.	.	.
cord-012902-efprpk72	318	1	Antihypertensive	antihypertensive	JJ
cord-012902-efprpk72	318	2	therapy	therapy	NN
cord-012902-efprpk72	318	3	was	be	VBD
cord-012902-efprpk72	318	4	not	not	RB
cord-012902-efprpk72	318	5	associated	associate	VBN
cord-012902-efprpk72	318	6	with	with	IN
cord-012902-efprpk72	318	7	an	an	DT
cord-012902-efprpk72	318	8	increased	increase	VBN
cord-012902-efprpk72	318	9	risk	risk	NN
cord-012902-efprpk72	318	10	of	of	IN
cord-012902-efprpk72	318	11	falls	fall	NNS
cord-012902-efprpk72	318	12	(	(	-LRB-
cord-012902-efprpk72	318	13	OR	or	CC
cord-012902-efprpk72	318	14	1.06	1.06	CD
cord-012902-efprpk72	318	15	,	,	,
cord-012902-efprpk72	318	16	95	95	CD
cord-012902-efprpk72	318	17	%	%	NN
cord-012902-efprpk72	318	18	CI	CI	NNP
cord-012902-efprpk72	318	19	0.88	0.88	CD
cord-012902-efprpk72	318	20	-	-	HYPH
cord-012902-efprpk72	318	21	1.27	1.27	CD
cord-012902-efprpk72	318	22	)	)	-RRB-
cord-012902-efprpk72	318	23	.	.	.
cord-012902-efprpk72	319	1	Treatment	treatment	NN
cord-012902-efprpk72	319	2	was	be	VBD
cord-012902-efprpk72	319	3	associated	associate	VBN
cord-012902-efprpk72	319	4	with	with	IN
cord-012902-efprpk72	319	5	an	an	DT
cord-012902-efprpk72	319	6	increased	increase	VBN
cord-012902-efprpk72	319	7	risk	risk	NN
cord-012902-efprpk72	319	8	of	of	IN
cord-012902-efprpk72	319	9	hyperkalemia	hyperkalemia	NN
cord-012902-efprpk72	319	10	(	(	-LRB-
cord-012902-efprpk72	319	11	OR	or	CC
cord-012902-efprpk72	319	12	1.69	1.69	CD
cord-012902-efprpk72	319	13	,	,	,
cord-012902-efprpk72	319	14	95	95	CD
cord-012902-efprpk72	319	15	%	%	NN
cord-012902-efprpk72	319	16	CI	CI	NNP
cord-012902-efprpk72	319	17	1.35	1.35	CD
cord-012902-efprpk72	319	18	-	-	HYPH
cord-012902-efprpk72	319	19	2.11	2.11	CD
cord-012902-efprpk72	319	20	)	)	-RRB-
cord-012902-efprpk72	319	21	as	as	RB
cord-012902-efprpk72	319	22	well	well	RB
cord-012902-efprpk72	319	23	as	as	IN
cord-012902-efprpk72	319	24	hypotension	hypotension	NN
cord-012902-efprpk72	319	25	(	(	-LRB-
cord-012902-efprpk72	319	26	OR	or	CC
cord-012902-efprpk72	319	27	1.81	1.81	CD
cord-012902-efprpk72	319	28	,	,	,
cord-012902-efprpk72	319	29	95	95	CD
cord-012902-efprpk72	319	30	%	%	NN
cord-012902-efprpk72	319	31	CI	CI	NNP
cord-012902-efprpk72	319	32	1.46	1.46	CD
cord-012902-efprpk72	319	33	-	-	SYM
cord-012902-efprpk72	319	34	2.26	2.26	CD
cord-012902-efprpk72	319	35	)	)	-RRB-
cord-012902-efprpk72	319	36	.	.	.
cord-012902-efprpk72	320	1	No	no	DT
cord-012902-efprpk72	320	2	significant	significant	JJ
cord-012902-efprpk72	320	3	association	association	NN
cord-012902-efprpk72	320	4	was	be	VBD
cord-012902-efprpk72	320	5	observed	observe	VBN
cord-012902-efprpk72	320	6	between	between	IN
cord-012902-efprpk72	320	7	antihypertensive	antihypertensive	JJ
cord-012902-efprpk72	320	8	treatment	treatment	NN
cord-012902-efprpk72	320	9	and	and	CC
cord-012902-efprpk72	320	10	falls	fall	VBZ
cord-012902-efprpk72	320	11	,	,	,
cord-012902-efprpk72	320	12	hypokalaemia	hypokalaemia	NN
cord-012902-efprpk72	320	13	,	,	,
cord-012902-efprpk72	320	14	AKI	AKI	NNP
cord-012902-efprpk72	320	15	,	,	,
cord-012902-efprpk72	320	16	or	or	CC
cord-012902-efprpk72	320	17	fractures	fracture	NNS
cord-012902-efprpk72	320	18	.	.	.
cord-012902-efprpk72	321	1	Conclusions	conclusion	NNS
cord-012902-efprpk72	321	2	:	:	:
cord-012902-efprpk72	322	1	While	while	IN
cord-012902-efprpk72	322	2	the	the	DT
cord-012902-efprpk72	322	3	benefits	benefit	NNS
cord-012902-efprpk72	322	4	of	of	IN
cord-012902-efprpk72	322	5	antihypertensive	antihypertensive	JJ
cord-012902-efprpk72	322	6	treatment	treatment	NN
cord-012902-efprpk72	322	7	have	have	VBP
cord-012902-efprpk72	322	8	been	be	VBN
cord-012902-efprpk72	322	9	studied	study	VBN
cord-012902-efprpk72	322	10	extensively	extensively	RB
cord-012902-efprpk72	322	11	and	and	CC
cord-012902-efprpk72	322	12	been	be	VBN
cord-012902-efprpk72	322	13	shown	show	VBN
cord-012902-efprpk72	322	14	to	to	TO
cord-012902-efprpk72	322	15	reduce	reduce	VB
cord-012902-efprpk72	322	16	the	the	DT
cord-012902-efprpk72	322	17	risk	risk	NN
cord-012902-efprpk72	322	18	of	of	IN
cord-012902-efprpk72	322	19	stroke	stroke	NN
cord-012902-efprpk72	322	20	and	and	CC
cord-012902-efprpk72	322	21	cardiovascular	cardiovascular	JJ
cord-012902-efprpk72	322	22	disease	disease	NN
cord-012902-efprpk72	322	23	,	,	,
cord-012902-efprpk72	322	24	the	the	DT
cord-012902-efprpk72	322	25	findings	finding	NNS
cord-012902-efprpk72	322	26	of	of	IN
cord-012902-efprpk72	322	27	this	this	DT
cord-012902-efprpk72	322	28	review	review	NN
cord-012902-efprpk72	322	29	demonstrate	demonstrate	VBP
cord-012902-efprpk72	322	30	that	that	IN
cord-012902-efprpk72	322	31	they	-PRON-	PRP
cord-012902-efprpk72	322	32	are	be	VBP
cord-012902-efprpk72	322	33	not	not	RB
cord-012902-efprpk72	322	34	without	without	IN
cord-012902-efprpk72	322	35	risk	risk	NN
cord-012902-efprpk72	322	36	of	of	IN
cord-012902-efprpk72	322	37	harm	harm	NN
cord-012902-efprpk72	322	38	.	.	.
cord-012902-efprpk72	323	1	Our	-PRON-	PRP$
cord-012902-efprpk72	323	2	review	review	NN
cord-012902-efprpk72	323	3	provides	provide	VBZ
cord-012902-efprpk72	323	4	useful	useful	JJ
cord-012902-efprpk72	323	5	evidence	evidence	NN
cord-012902-efprpk72	323	6	about	about	IN
cord-012902-efprpk72	323	7	the	the	DT
cord-012902-efprpk72	323	8	harms	harm	NNS
cord-012902-efprpk72	323	9	of	of	IN
cord-012902-efprpk72	323	10	therapy	therapy	NN
cord-012902-efprpk72	323	11	which	which	WDT
cord-012902-efprpk72	323	12	will	will	MD
cord-012902-efprpk72	323	13	enable	enable	VB
cord-012902-efprpk72	323	14	clinicians	clinician	NNS
cord-012902-efprpk72	323	15	and	and	CC
cord-012902-efprpk72	323	16	patients	patient	NNS
cord-012902-efprpk72	323	17	to	to	TO
cord-012902-efprpk72	323	18	make	make	VB
cord-012902-efprpk72	323	19	better	well	JJR
cord-012902-efprpk72	323	20	informed	informed	JJ
cord-012902-efprpk72	323	21	decisions	decision	NNS
cord-012902-efprpk72	323	22	regarding	regard	VBG
cord-012902-efprpk72	323	23	the	the	DT
cord-012902-efprpk72	323	24	use	use	NN
cord-012902-efprpk72	323	25	of	of	IN
cord-012902-efprpk72	323	26	anti	anti	JJ
cord-012902-efprpk72	323	27	-	-	JJ
cord-012902-efprpk72	323	28	hypertensive	hypertensive	JJ
cord-012902-efprpk72	323	29	therapies	therapy	NNS
cord-012902-efprpk72	323	30	,	,	,
cord-012902-efprpk72	323	31	particularly	particularly	RB
cord-012902-efprpk72	323	32	in	in	IN
cord-012902-efprpk72	323	33	older	old	JJR
cord-012902-efprpk72	323	34	patients	patient	NNS
cord-012902-efprpk72	323	35	.	.	.
cord-012902-efprpk72	324	1	Disclosures	disclosure	NNS
cord-012902-efprpk72	324	2	:	:	:
cord-012902-efprpk72	324	3	None	none	NN
cord-012902-efprpk72	324	4	.	.	.
cord-012902-efprpk72	325	1	Gwyneth	Gwyneth	NNP
cord-012902-efprpk72	325	2	Lawson	Lawson	NNP
cord-012902-efprpk72	325	3	1	1	CD
cord-012902-efprpk72	326	1	*	*	NFP
cord-012902-efprpk72	326	2	,	,	,
cord-012902-efprpk72	326	3	Richard	Richard	NNP
cord-012902-efprpk72	326	4	Fish	Fish	NNP
cord-012902-efprpk72	326	5	1	1	CD
cord-012902-efprpk72	326	6	Introduction	introduction	NN
cord-012902-efprpk72	326	7	:	:	:
cord-012902-efprpk72	327	1	Resistant	resistant	JJ
cord-012902-efprpk72	327	2	hypertension	hypertension	NN
cord-012902-efprpk72	327	3	is	be	VBZ
cord-012902-efprpk72	327	4	frequently	frequently	RB
cord-012902-efprpk72	327	5	defined	define	VBN
cord-012902-efprpk72	327	6	as	as	IN
cord-012902-efprpk72	327	7	a	a	DT
cord-012902-efprpk72	327	8	mean	mean	JJ
cord-012902-efprpk72	327	9	daytime	daytime	JJ
cord-012902-efprpk72	327	10	blood	blood	NN
cord-012902-efprpk72	327	11	pressure	pressure	NN
cord-012902-efprpk72	327	12	(	(	-LRB-
cord-012902-efprpk72	327	13	BP	BP	NNP
cord-012902-efprpk72	327	14	)	)	-RRB-
cord-012902-efprpk72	327	15	≥135/85	≥135/85	NNP
cord-012902-efprpk72	327	16	despite	despite	IN
cord-012902-efprpk72	327	17	the	the	DT
cord-012902-efprpk72	327	18	use	use	NN
cord-012902-efprpk72	327	19	of	of	IN
cord-012902-efprpk72	327	20	three	three	CD
cord-012902-efprpk72	327	21	or	or	CC
cord-012902-efprpk72	327	22	more	more	JJR
cord-012902-efprpk72	327	23	anti	anti	JJ
cord-012902-efprpk72	327	24	-	-	JJ
cord-012902-efprpk72	327	25	hypertensives	hypertensive	NNS
cord-012902-efprpk72	327	26	.	.	.
cord-012902-efprpk72	328	1	We	-PRON-	PRP
cord-012902-efprpk72	328	2	investigated	investigate	VBD
cord-012902-efprpk72	328	3	whether	whether	IN
cord-012902-efprpk72	328	4	directly	directly	RB
cord-012902-efprpk72	328	5	observed	observe	VBN
cord-012902-efprpk72	328	6	administration	administration	NN
cord-012902-efprpk72	328	7	(	(	-LRB-
cord-012902-efprpk72	328	8	DOA	DOA	NNP
cord-012902-efprpk72	328	9	)	)	-RRB-
cord-012902-efprpk72	328	10	of	of	IN
cord-012902-efprpk72	328	11	antihypertensive	antihypertensive	JJ
cord-012902-efprpk72	328	12	medications	medication	NNS
cord-012902-efprpk72	328	13	immediately	immediately	RB
cord-012902-efprpk72	328	14	before	before	IN
cord-012902-efprpk72	328	15	24-h	24-h	JJ
cord-012902-efprpk72	328	16	ambulatory	ambulatory	JJ
cord-012902-efprpk72	328	17	blood	blood	NN
cord-012902-efprpk72	328	18	pressure	pressure	NN
cord-012902-efprpk72	328	19	monitoring	monitoring	NN
cord-012902-efprpk72	328	20	(	(	-LRB-
cord-012902-efprpk72	328	21	ABPM	ABPM	NNP
cord-012902-efprpk72	328	22	)	)	-RRB-
cord-012902-efprpk72	328	23	would	would	MD
cord-012902-efprpk72	328	24	help	help	VB
cord-012902-efprpk72	328	25	exclude	exclude	VB
cord-012902-efprpk72	328	26	'	'	``
cord-012902-efprpk72	328	27	treatment	treatment	NN
cord-012902-efprpk72	328	28	resistance	resistance	NN
cord-012902-efprpk72	328	29	'	'	''
cord-012902-efprpk72	328	30	potentially	potentially	RB
cord-012902-efprpk72	328	31	caused	cause	VBN
cord-012902-efprpk72	328	32	by	by	IN
cord-012902-efprpk72	328	33	medication	medication	NN
cord-012902-efprpk72	328	34	non	non	JJ
cord-012902-efprpk72	328	35	-	-	JJ
cord-012902-efprpk72	328	36	adherence	adherence	NN
cord-012902-efprpk72	328	37	.	.	.
cord-012902-efprpk72	329	1	Methods	method	NNS
cord-012902-efprpk72	329	2	:	:	:
cord-012902-efprpk72	329	3	Patients	patient	NNS
cord-012902-efprpk72	329	4	attending	attend	VBG
cord-012902-efprpk72	329	5	our	-PRON-	PRP$
cord-012902-efprpk72	329	6	nurse	nurse	NN
cord-012902-efprpk72	329	7	-	-	HYPH
cord-012902-efprpk72	329	8	led	lead	VBN
cord-012902-efprpk72	329	9	hypertension	hypertension	NN
cord-012902-efprpk72	329	10	clinic	clinic	NN
cord-012902-efprpk72	329	11	were	be	VBD
cord-012902-efprpk72	329	12	requested	request	VBN
cord-012902-efprpk72	329	13	in	in	IN
cord-012902-efprpk72	329	14	advance	advance	NN
cord-012902-efprpk72	329	15	to	to	TO
cord-012902-efprpk72	329	16	not	not	RB
cord-012902-efprpk72	329	17	take	take	VB
cord-012902-efprpk72	329	18	their	-PRON-	PRP$
cord-012902-efprpk72	329	19	prescribed	prescribed	JJ
cord-012902-efprpk72	329	20	anti	anti	JJ
cord-012902-efprpk72	329	21	-	-	JJ
cord-012902-efprpk72	329	22	hypertensives	hypertensive	NNS
cord-012902-efprpk72	329	23	before	before	IN
cord-012902-efprpk72	329	24	their	-PRON-	PRP$
cord-012902-efprpk72	329	25	morning	morning	NN
cord-012902-efprpk72	329	26	appointment	appointment	NN
cord-012902-efprpk72	329	27	but	but	CC
cord-012902-efprpk72	329	28	instead	instead	RB
cord-012902-efprpk72	329	29	to	to	TO
cord-012902-efprpk72	329	30	bring	bring	VB
cord-012902-efprpk72	329	31	them	-PRON-	PRP
cord-012902-efprpk72	329	32	with	with	IN
cord-012902-efprpk72	329	33	.	.	.
cord-012902-efprpk72	330	1	Patients	patient	NNS
cord-012902-efprpk72	330	2	were	be	VBD
cord-012902-efprpk72	330	3	then	then	RB
cord-012902-efprpk72	330	4	observed	observe	VBN
cord-012902-efprpk72	330	5	taking	take	VBG
cord-012902-efprpk72	330	6	their	-PRON-	PRP$
cord-012902-efprpk72	330	7	anti	anti	JJ
cord-012902-efprpk72	330	8	-	-	JJ
cord-012902-efprpk72	330	9	hypertensives	hypertensive	NNS
cord-012902-efprpk72	330	10	before	before	IN
cord-012902-efprpk72	330	11	ABPM	ABPM	NNP
cord-012902-efprpk72	330	12	.	.	.
cord-012902-efprpk72	331	1	Patients	patient	NNS
cord-012902-efprpk72	331	2	not	not	RB
cord-012902-efprpk72	331	3	following	follow	VBG
cord-012902-efprpk72	331	4	these	these	DT
cord-012902-efprpk72	331	5	instructions	instruction	NNS
cord-012902-efprpk72	331	6	or	or	CC
cord-012902-efprpk72	331	7	who	who	WP
cord-012902-efprpk72	331	8	had	have	VBD
cord-012902-efprpk72	331	9	ABPM	ABPM	NNP
cord-012902-efprpk72	331	10	organised	organise	VBN
cord-012902-efprpk72	331	11	from	from	IN
cord-012902-efprpk72	331	12	another	another	DT
cord-012902-efprpk72	331	13	clinic	clinic	NN
cord-012902-efprpk72	331	14	formed	form	VBD
cord-012902-efprpk72	331	15	the	the	DT
cord-012902-efprpk72	331	16	control	control	NN
cord-012902-efprpk72	331	17	group	group	NN
cord-012902-efprpk72	331	18	.	.	.
cord-012902-efprpk72	332	1	Proportions	proportion	NNS
cord-012902-efprpk72	332	2	were	be	VBD
cord-012902-efprpk72	332	3	compared	compare	VBN
cord-012902-efprpk72	332	4	with	with	IN
cord-012902-efprpk72	332	5	Chi	Chi	NNP
cord-012902-efprpk72	332	6	-	-	HYPH
cord-012902-efprpk72	332	7	square	square	JJ
cord-012902-efprpk72	332	8	tests	test	NNS
cord-012902-efprpk72	332	9	and	and	CC
cord-012902-efprpk72	332	10	data	data	NN
cord-012902-efprpk72	332	11	analysis	analysis	NN
cord-012902-efprpk72	332	12	using	use	VBG
cord-012902-efprpk72	332	13	Microsoft	Microsoft	NNP
cord-012902-efprpk72	332	14	EXCEL	EXCEL	NNP
cord-012902-efprpk72	332	15	2010	2010	CD
cord-012902-efprpk72	332	16	[	[	-LRB-
cord-012902-efprpk72	332	17	1	1	CD
cord-012902-efprpk72	332	18	]	]	-RRB-
cord-012902-efprpk72	332	19	.	.	.
cord-012902-efprpk72	333	1	Results	result	NNS
cord-012902-efprpk72	333	2	Conclusions	conclusion	NNS
cord-012902-efprpk72	333	3	:	:	:
cord-012902-efprpk72	334	1	Eliminating	eliminate	VBG
cord-012902-efprpk72	334	2	any	any	DT
cord-012902-efprpk72	334	3	effect	effect	NN
cord-012902-efprpk72	334	4	of	of	IN
cord-012902-efprpk72	334	5	medication	medication	NN
cord-012902-efprpk72	334	6	nonadherence	nonadherence	NN
cord-012902-efprpk72	334	7	by	by	IN
cord-012902-efprpk72	334	8	DOA	DOA	NNP
cord-012902-efprpk72	334	9	of	of	IN
cord-012902-efprpk72	334	10	prescribed	prescribed	JJ
cord-012902-efprpk72	334	11	anti	anti	NNP
cord-012902-efprpk72	334	12	-	-	JJ
cord-012902-efprpk72	334	13	hypertensives	hypertensives	NNP
cord-012902-efprpk72	334	14	immediately	immediately	RB
cord-012902-efprpk72	334	15	before	before	IN
cord-012902-efprpk72	334	16	ABPM	ABPM	NNP
cord-012902-efprpk72	334	17	leads	lead	VBZ
cord-012902-efprpk72	334	18	to	to	IN
cord-012902-efprpk72	334	19	a	a	DT
cord-012902-efprpk72	334	20	lower	low	JJR
cord-012902-efprpk72	334	21	rate	rate	NN
cord-012902-efprpk72	334	22	of	of	IN
cord-012902-efprpk72	334	23	'	'	``
cord-012902-efprpk72	334	24	resistant	resistant	JJ
cord-012902-efprpk72	334	25	hypertension	hypertension	NN
cord-012902-efprpk72	334	26	'	'	''
cord-012902-efprpk72	334	27	diagnoses	diagnosis	NNS
cord-012902-efprpk72	334	28	.	.	.
cord-012902-efprpk72	335	1	This	this	DT
cord-012902-efprpk72	335	2	strategy	strategy	NN
cord-012902-efprpk72	335	3	may	may	MD
cord-012902-efprpk72	335	4	therefore	therefore	RB
cord-012902-efprpk72	335	5	eliminate	eliminate	VB
cord-012902-efprpk72	335	6	the	the	DT
cord-012902-efprpk72	335	7	need	need	NN
cord-012902-efprpk72	335	8	for	for	IN
cord-012902-efprpk72	335	9	further	further	JJ
cord-012902-efprpk72	335	10	treatment	treatment	NN
cord-012902-efprpk72	335	11	and/or	and/or	CC
cord-012902-efprpk72	335	12	investigation	investigation	NN
cord-012902-efprpk72	335	13	in	in	IN
cord-012902-efprpk72	335	14	some	some	DT
cord-012902-efprpk72	335	15	patients	patient	NNS
cord-012902-efprpk72	335	16	.	.	.
cord-012902-efprpk72	336	1	Disclosures	disclosure	NNS
cord-012902-efprpk72	336	2	:	:	:
cord-012902-efprpk72	336	3	None	none	NN
cord-012902-efprpk72	336	4	.	.	.
cord-012902-efprpk72	337	1	Introduction	introduction	NN
cord-012902-efprpk72	337	2	:	:	:
cord-012902-efprpk72	338	1	During	during	IN
cord-012902-efprpk72	338	2	medicine	medicine	NN
cord-012902-efprpk72	338	3	reconciliations	reconciliation	NNS
cord-012902-efprpk72	338	4	on	on	IN
cord-012902-efprpk72	338	5	admission	admission	NN
cord-012902-efprpk72	338	6	medications	medication	NNS
cord-012902-efprpk72	338	7	are	be	VBP
cord-012902-efprpk72	338	8	often	often	RB
cord-012902-efprpk72	338	9	stopped	stop	VBN
cord-012902-efprpk72	338	10	or	or	CC
cord-012902-efprpk72	338	11	withheld	withhold	VBN
cord-012902-efprpk72	338	12	for	for	IN
cord-012902-efprpk72	338	13	various	various	JJ
cord-012902-efprpk72	338	14	reasons	reason	NNS
cord-012902-efprpk72	338	15	.	.	.
cord-012902-efprpk72	339	1	This	this	DT
cord-012902-efprpk72	339	2	audit	audit	NN
cord-012902-efprpk72	339	3	focussed	focusse	VBD
cord-012902-efprpk72	339	4	on	on	IN
cord-012902-efprpk72	339	5	antihypertensives	antihypertensive	NNS
cord-012902-efprpk72	339	6	.	.	.
cord-012902-efprpk72	340	1	The	the	DT
cord-012902-efprpk72	340	2	aim	aim	NN
cord-012902-efprpk72	340	3	was	be	VBD
cord-012902-efprpk72	340	4	to	to	TO
cord-012902-efprpk72	340	5	establish	establish	VB
cord-012902-efprpk72	340	6	whether	whether	IN
cord-012902-efprpk72	340	7	these	these	DT
cord-012902-efprpk72	340	8	medications	medication	NNS
cord-012902-efprpk72	340	9	were	be	VBD
cord-012902-efprpk72	340	10	discontinued	discontinue	VBN
cord-012902-efprpk72	340	11	appropriately	appropriately	RB
cord-012902-efprpk72	340	12	,	,	,
cord-012902-efprpk72	340	13	whether	whether	IN
cord-012902-efprpk72	340	14	they	-PRON-	PRP
cord-012902-efprpk72	340	15	were	be	VBD
cord-012902-efprpk72	340	16	restarted	restart	VBN
cord-012902-efprpk72	340	17	and	and	CC
cord-012902-efprpk72	340	18	if	if	IN
cord-012902-efprpk72	340	19	there	there	EX
cord-012902-efprpk72	340	20	was	be	VBD
cord-012902-efprpk72	340	21	communication	communication	NN
cord-012902-efprpk72	340	22	between	between	IN
cord-012902-efprpk72	340	23	primary	primary	JJ
cord-012902-efprpk72	340	24	and	and	CC
cord-012902-efprpk72	340	25	secondary	secondary	JJ
cord-012902-efprpk72	340	26	care	care	NN
cord-012902-efprpk72	340	27	regarding	regard	VBG
cord-012902-efprpk72	340	28	changes	change	NNS
cord-012902-efprpk72	340	29	.	.	.
cord-012902-efprpk72	341	1	Methods	method	NNS
cord-012902-efprpk72	341	2	:	:	:
cord-012902-efprpk72	341	3	Data	datum	NNS
cord-012902-efprpk72	341	4	was	be	VBD
cord-012902-efprpk72	341	5	collected	collect	VBN
cord-012902-efprpk72	341	6	from	from	IN
cord-012902-efprpk72	341	7	82	82	CD
cord-012902-efprpk72	341	8	patients	patient	NNS
cord-012902-efprpk72	341	9	over	over	IN
cord-012902-efprpk72	341	10	the	the	DT
cord-012902-efprpk72	341	11	course	course	NN
cord-012902-efprpk72	341	12	of	of	IN
cord-012902-efprpk72	341	13	2	2	CD
cord-012902-efprpk72	341	14	weeks	week	NNS
cord-012902-efprpk72	341	15	prospectively	prospectively	RB
cord-012902-efprpk72	341	16	.	.	.
cord-012902-efprpk72	342	1	Immediate	immediate	JJ
cord-012902-efprpk72	342	2	discharge	discharge	NN
cord-012902-efprpk72	342	3	letters	letter	NNS
cord-012902-efprpk72	342	4	,	,	,
cord-012902-efprpk72	342	5	medical	medical	JJ
cord-012902-efprpk72	342	6	notes	note	NNS
cord-012902-efprpk72	342	7	and	and	CC
cord-012902-efprpk72	342	8	nursing	nursing	NN
cord-012902-efprpk72	342	9	notes	note	NNS
cord-012902-efprpk72	342	10	were	be	VBD
cord-012902-efprpk72	342	11	reviewed	review	VBN
cord-012902-efprpk72	342	12	after	after	IN
cord-012902-efprpk72	342	13	discharge	discharge	NN
cord-012902-efprpk72	342	14	.	.	.
cord-012902-efprpk72	343	1	The	the	DT
cord-012902-efprpk72	343	2	data	datum	NNS
cord-012902-efprpk72	343	3	collected	collect	VBD
cord-012902-efprpk72	343	4	included	include	VBN
cord-012902-efprpk72	343	5	whether	whether	IN
cord-012902-efprpk72	343	6	patients	patient	NNS
cord-012902-efprpk72	343	7	had	have	VBD
cord-012902-efprpk72	343	8	known	know	VBN
cord-012902-efprpk72	343	9	cardiovascular	cardiovascular	JJ
cord-012902-efprpk72	343	10	disease	disease	NN
cord-012902-efprpk72	343	11	,	,	,
cord-012902-efprpk72	343	12	if	if	IN
cord-012902-efprpk72	343	13	they	-PRON-	PRP
cord-012902-efprpk72	343	14	were	be	VBD
cord-012902-efprpk72	343	15	taking	take	VBG
cord-012902-efprpk72	343	16	antihypertensives	antihypertensive	NNS
cord-012902-efprpk72	343	17	,	,	,
cord-012902-efprpk72	343	18	if	if	IN
cord-012902-efprpk72	343	19	medications	medication	NNS
cord-012902-efprpk72	343	20	were	be	VBD
cord-012902-efprpk72	343	21	stopped	stop	VBN
cord-012902-efprpk72	343	22	,	,	,
cord-012902-efprpk72	343	23	the	the	DT
cord-012902-efprpk72	343	24	indication	indication	NN
cord-012902-efprpk72	343	25	,	,	,
cord-012902-efprpk72	343	26	and	and	CC
cord-012902-efprpk72	343	27	whether	whether	IN
cord-012902-efprpk72	343	28	these	these	DT
cord-012902-efprpk72	343	29	changes	change	NNS
cord-012902-efprpk72	343	30	were	be	VBD
cord-012902-efprpk72	343	31	communicated	communicate	VBN
cord-012902-efprpk72	343	32	to	to	IN
cord-012902-efprpk72	343	33	the	the	DT
cord-012902-efprpk72	343	34	patients	patient	NNS
cord-012902-efprpk72	343	35	'	'	POS
cord-012902-efprpk72	343	36	GP	gp	NN
cord-012902-efprpk72	343	37	.	.	.
cord-012902-efprpk72	344	1	Results	result	NNS
cord-012902-efprpk72	344	2	:	:	:
cord-012902-efprpk72	345	1	Data	datum	NNS
cord-012902-efprpk72	345	2	was	be	VBD
cord-012902-efprpk72	345	3	collected	collect	VBN
cord-012902-efprpk72	345	4	from	from	IN
cord-012902-efprpk72	345	5	82	82	CD
cord-012902-efprpk72	345	6	patients	patient	NNS
cord-012902-efprpk72	345	7	.	.	.
cord-012902-efprpk72	346	1	From	from	IN
cord-012902-efprpk72	346	2	this	this	DT
cord-012902-efprpk72	346	3	cohort	cohort	NN
cord-012902-efprpk72	346	4	43.9	43.9	CD
cord-012902-efprpk72	346	5	%	%	NN
cord-012902-efprpk72	346	6	(	(	-LRB-
cord-012902-efprpk72	346	7	N	n	NN
cord-012902-efprpk72	346	8	=	=	SYM
cord-012902-efprpk72	346	9	36	36	CD
cord-012902-efprpk72	346	10	)	)	-RRB-
cord-012902-efprpk72	346	11	had	have	VBD
cord-012902-efprpk72	346	12	known	know	VBN
cord-012902-efprpk72	346	13	cardiovascular	cardiovascular	JJ
cord-012902-efprpk72	346	14	disease	disease	NN
cord-012902-efprpk72	346	15	and	and	CC
cord-012902-efprpk72	346	16	47.56	47.56	CD
cord-012902-efprpk72	346	17	%	%	NN
cord-012902-efprpk72	346	18	(	(	-LRB-
cord-012902-efprpk72	346	19	N	n	NN
cord-012902-efprpk72	346	20	=	=	SYM
cord-012902-efprpk72	346	21	39	39	CD
cord-012902-efprpk72	346	22	)	)	-RRB-
cord-012902-efprpk72	346	23	were	be	VBD
cord-012902-efprpk72	346	24	taking	take	VBG
cord-012902-efprpk72	346	25	one	one	CD
cord-012902-efprpk72	346	26	or	or	CC
cord-012902-efprpk72	346	27	more	more	JJR
cord-012902-efprpk72	346	28	antihypertensive	antihypertensive	JJ
cord-012902-efprpk72	346	29	agents	agent	NNS
cord-012902-efprpk72	346	30	on	on	IN
cord-012902-efprpk72	346	31	presentation	presentation	NN
cord-012902-efprpk72	346	32	to	to	IN
cord-012902-efprpk72	346	33	hospital	hospital	NN
cord-012902-efprpk72	346	34	.	.	.
cord-012902-efprpk72	347	1	During	during	IN
cord-012902-efprpk72	347	2	admission	admission	NN
cord-012902-efprpk72	347	3	51.28	51.28	CD
cord-012902-efprpk72	347	4	%	%	NN
cord-012902-efprpk72	347	5	(	(	-LRB-
cord-012902-efprpk72	347	6	N	n	NN
cord-012902-efprpk72	347	7	=	=	SYM
cord-012902-efprpk72	347	8	20/39	20/39	CD
cord-012902-efprpk72	347	9	)	)	-RRB-
cord-012902-efprpk72	347	10	had	have	VBD
cord-012902-efprpk72	347	11	one	one	CD
cord-012902-efprpk72	347	12	or	or	CC
cord-012902-efprpk72	347	13	more	more	JJR
cord-012902-efprpk72	347	14	antihypertensive	antihypertensive	JJ
cord-012902-efprpk72	347	15	agents	agent	NNS
cord-012902-efprpk72	347	16	discontinued	discontinue	VBD
cord-012902-efprpk72	347	17	.	.	.
cord-012902-efprpk72	348	1	Of	of	IN
cord-012902-efprpk72	348	2	the	the	DT
cord-012902-efprpk72	348	3	20	20	CD
cord-012902-efprpk72	348	4	patients	patient	NNS
cord-012902-efprpk72	348	5	who	who	WP
cord-012902-efprpk72	348	6	had	have	VBD
cord-012902-efprpk72	348	7	antihypertensive	antihypertensive	JJ
cord-012902-efprpk72	348	8	agents	agent	NNS
cord-012902-efprpk72	348	9	discontinued	discontinue	VBD
cord-012902-efprpk72	348	10	20	20	CD
cord-012902-efprpk72	348	11	%	%	NN
cord-012902-efprpk72	348	12	(	(	-LRB-
cord-012902-efprpk72	348	13	N	n	NN
cord-012902-efprpk72	348	14	=	=	SYM
cord-012902-efprpk72	348	15	4/20	4/20	CD
cord-012902-efprpk72	348	16	)	)	-RRB-
cord-012902-efprpk72	348	17	were	be	VBD
cord-012902-efprpk72	348	18	restarted	restart	VBN
cord-012902-efprpk72	348	19	either	either	CC
cord-012902-efprpk72	348	20	before	before	IN
cord-012902-efprpk72	348	21	or	or	CC
cord-012902-efprpk72	348	22	on	on	IN
cord-012902-efprpk72	348	23	discharge	discharge	NN
cord-012902-efprpk72	348	24	.	.	.
cord-012902-efprpk72	349	1	85	85	CD
cord-012902-efprpk72	349	2	%	%	NN
cord-012902-efprpk72	349	3	(	(	-LRB-
cord-012902-efprpk72	349	4	N	n	NN
cord-012902-efprpk72	349	5	=	=	SYM
cord-012902-efprpk72	349	6	17/	17/	CD
cord-012902-efprpk72	349	7	20	20	CD
cord-012902-efprpk72	349	8	)	)	-RRB-
cord-012902-efprpk72	349	9	of	of	IN
cord-012902-efprpk72	349	10	discontinuations	discontinuation	NNS
cord-012902-efprpk72	349	11	were	be	VBD
cord-012902-efprpk72	349	12	communicated	communicate	VBN
cord-012902-efprpk72	349	13	to	to	IN
cord-012902-efprpk72	349	14	the	the	DT
cord-012902-efprpk72	349	15	patients	patient	NNS
cord-012902-efprpk72	349	16	'	'	POS
cord-012902-efprpk72	349	17	GP	gp	NN
cord-012902-efprpk72	349	18	.	.	.
cord-012902-efprpk72	350	1	50	50	CD
cord-012902-efprpk72	350	2	%	%	NN
cord-012902-efprpk72	351	1	(	(	-LRB-
cord-012902-efprpk72	351	2	N	n	NN
cord-012902-efprpk72	351	3	=	=	SYM
cord-012902-efprpk72	351	4	10/20	10/20	CD
cord-012902-efprpk72	351	5	)	)	-RRB-
cord-012902-efprpk72	351	6	patients	patient	NNS
cord-012902-efprpk72	351	7	had	have	VBD
cord-012902-efprpk72	351	8	medications	medication	NNS
cord-012902-efprpk72	351	9	discontinued	discontinue	VBN
cord-012902-efprpk72	351	10	due	due	IN
cord-012902-efprpk72	351	11	to	to	IN
cord-012902-efprpk72	351	12	acute	acute	JJ
cord-012902-efprpk72	351	13	kidney	kidney	NN
cord-012902-efprpk72	351	14	injury	injury	NN
cord-012902-efprpk72	351	15	.	.	.
cord-012902-efprpk72	352	1	15	15	CD
cord-012902-efprpk72	352	2	%	%	NN
cord-012902-efprpk72	352	3	(	(	-LRB-
cord-012902-efprpk72	352	4	N	n	NN
cord-012902-efprpk72	352	5	=	=	SYM
cord-012902-efprpk72	352	6	3/20	3/20	CD
cord-012902-efprpk72	352	7	)	)	-RRB-
cord-012902-efprpk72	352	8	were	be	VBD
cord-012902-efprpk72	352	9	discontinued	discontinue	VBN
cord-012902-efprpk72	352	10	as	as	IN
cord-012902-efprpk72	352	11	patients	patient	NNS
cord-012902-efprpk72	352	12	were	be	VBD
cord-012902-efprpk72	352	13	either	either	CC
cord-012902-efprpk72	352	14	normotensive	normotensive	JJ
cord-012902-efprpk72	352	15	or	or	CC
cord-012902-efprpk72	352	16	hypotensive	hypotensive	JJ
cord-012902-efprpk72	352	17	,	,	,
cord-012902-efprpk72	352	18	and	and	CC
cord-012902-efprpk72	352	19	in	in	IN
cord-012902-efprpk72	352	20	10	10	CD
cord-012902-efprpk72	352	21	%	%	NN
cord-012902-efprpk72	352	22	(	(	-LRB-
cord-012902-efprpk72	352	23	N	n	NN
cord-012902-efprpk72	352	24	=	=	SYM
cord-012902-efprpk72	352	25	2/20	2/20	CD
cord-012902-efprpk72	352	26	)	)	-RRB-
cord-012902-efprpk72	352	27	the	the	DT
cord-012902-efprpk72	352	28	indication	indication	NN
cord-012902-efprpk72	352	29	was	be	VBD
cord-012902-efprpk72	352	30	undocumented	undocumented	JJ
cord-012902-efprpk72	352	31	.	.	.
cord-012902-efprpk72	353	1	The	the	DT
cord-012902-efprpk72	353	2	remaining	remain	VBG
cord-012902-efprpk72	353	3	25	25	CD
cord-012902-efprpk72	353	4	%	%	NN
cord-012902-efprpk72	353	5	(	(	-LRB-
cord-012902-efprpk72	353	6	N	n	NN
cord-012902-efprpk72	353	7	=	=	SYM
cord-012902-efprpk72	353	8	5/20	5/20	CD
cord-012902-efprpk72	353	9	)	)	-RRB-
cord-012902-efprpk72	353	10	had	have	VBD
cord-012902-efprpk72	353	11	their	-PRON-	PRP$
cord-012902-efprpk72	353	12	medications	medication	NNS
cord-012902-efprpk72	353	13	discontinued	discontinue	VBN
cord-012902-efprpk72	353	14	due	due	IN
cord-012902-efprpk72	353	15	to	to	IN
cord-012902-efprpk72	353	16	intentional	intentional	JJ
cord-012902-efprpk72	353	17	overdose	overdose	NN
cord-012902-efprpk72	353	18	,	,	,
cord-012902-efprpk72	353	19	poor	poor	JJ
cord-012902-efprpk72	353	20	therapeutic	therapeutic	JJ
cord-012902-efprpk72	353	21	response	response	NN
cord-012902-efprpk72	353	22	,	,	,
cord-012902-efprpk72	353	23	side	side	NN
cord-012902-efprpk72	353	24	effects	effect	NNS
cord-012902-efprpk72	353	25	or	or	CC
cord-012902-efprpk72	353	26	intolerance	intolerance	NN
cord-012902-efprpk72	353	27	(	(	-LRB-
cord-012902-efprpk72	353	28	N	n	NN
cord-012902-efprpk72	353	29	=	=	SYM
cord-012902-efprpk72	353	30	2/20	2/20	CD
cord-012902-efprpk72	353	31	)	)	-RRB-
cord-012902-efprpk72	353	32	,	,	,
cord-012902-efprpk72	353	33	and	and	CC
cord-012902-efprpk72	353	34	system	system	NN
cord-012902-efprpk72	353	35	error	error	NN
cord-012902-efprpk72	353	36	respectively	respectively	RB
cord-012902-efprpk72	353	37	.	.	.
cord-012902-efprpk72	354	1	Conclusions	conclusion	NNS
cord-012902-efprpk72	354	2	:	:	:
cord-012902-efprpk72	355	1	Medications	medication	NNS
cord-012902-efprpk72	355	2	were	be	VBD
cord-012902-efprpk72	355	3	mostly	mostly	RB
cord-012902-efprpk72	355	4	discontinued	discontinue	VBN
cord-012902-efprpk72	355	5	appropriately	appropriately	RB
cord-012902-efprpk72	355	6	.	.	.
cord-012902-efprpk72	356	1	Only	only	RB
cord-012902-efprpk72	356	2	20	20	CD
cord-012902-efprpk72	356	3	%	%	NN
cord-012902-efprpk72	356	4	of	of	IN
cord-012902-efprpk72	356	5	patients	patient	NNS
cord-012902-efprpk72	356	6	were	be	VBD
cord-012902-efprpk72	356	7	documented	document	VBN
cord-012902-efprpk72	356	8	to	to	TO
cord-012902-efprpk72	356	9	have	have	VB
cord-012902-efprpk72	356	10	restarted	restart	VBN
cord-012902-efprpk72	356	11	their	-PRON-	PRP$
cord-012902-efprpk72	356	12	medications	medication	NNS
cord-012902-efprpk72	356	13	and	and	CC
cord-012902-efprpk72	356	14	so	so	RB
cord-012902-efprpk72	356	15	can	can	MD
cord-012902-efprpk72	356	16	not	not	RB
cord-012902-efprpk72	356	17	assess	assess	VB
cord-012902-efprpk72	356	18	whether	whether	IN
cord-012902-efprpk72	356	19	medications	medication	NNS
cord-012902-efprpk72	356	20	were	be	VBD
cord-012902-efprpk72	356	21	restarted	restart	VBN
cord-012902-efprpk72	356	22	appropriately	appropriately	RB
cord-012902-efprpk72	356	23	.	.	.
cord-012902-efprpk72	357	1	A	a	DT
cord-012902-efprpk72	357	2	high	high	JJ
cord-012902-efprpk72	357	3	proportion	proportion	NN
cord-012902-efprpk72	357	4	of	of	IN
cord-012902-efprpk72	357	5	medication	medication	NN
cord-012902-efprpk72	357	6	amendments	amendment	NNS
cord-012902-efprpk72	357	7	(	(	-LRB-
cord-012902-efprpk72	357	8	85	85	CD
cord-012902-efprpk72	357	9	%	%	NN
cord-012902-efprpk72	357	10	)	)	-RRB-
cord-012902-efprpk72	357	11	were	be	VBD
cord-012902-efprpk72	357	12	communicated	communicate	VBN
cord-012902-efprpk72	357	13	to	to	IN
cord-012902-efprpk72	357	14	the	the	DT
cord-012902-efprpk72	357	15	patient	patient	NN
cord-012902-efprpk72	357	16	's	's	POS
cord-012902-efprpk72	357	17	GP	gp	NN
cord-012902-efprpk72	357	18	via	via	IN
cord-012902-efprpk72	357	19	immediate	immediate	JJ
cord-012902-efprpk72	357	20	discharge	discharge	NN
cord-012902-efprpk72	357	21	letters	letter	NNS
cord-012902-efprpk72	357	22	.	.	.
cord-012902-efprpk72	358	1	However	however	RB
cord-012902-efprpk72	358	2	,	,	,
cord-012902-efprpk72	358	3	15	15	CD
cord-012902-efprpk72	358	4	%	%	NN
cord-012902-efprpk72	358	5	of	of	IN
cord-012902-efprpk72	358	6	patients	patient	NNS
cord-012902-efprpk72	358	7	did	do	VBD
cord-012902-efprpk72	358	8	not	not	RB
cord-012902-efprpk72	358	9	and	and	CC
cord-012902-efprpk72	358	10	so	so	RB
cord-012902-efprpk72	358	11	there	there	EX
cord-012902-efprpk72	358	12	is	be	VBZ
cord-012902-efprpk72	358	13	a	a	DT
cord-012902-efprpk72	358	14	substantial	substantial	JJ
cord-012902-efprpk72	358	15	proportion	proportion	NN
cord-012902-efprpk72	358	16	of	of	IN
cord-012902-efprpk72	358	17	patients	patient	NNS
cord-012902-efprpk72	358	18	going	go	VBG
cord-012902-efprpk72	358	19	into	into	IN
cord-012902-efprpk72	358	20	the	the	DT
cord-012902-efprpk72	358	21	community	community	NN
cord-012902-efprpk72	358	22	with	with	IN
cord-012902-efprpk72	358	23	potential	potential	JJ
cord-012902-efprpk72	358	24	medication	medication	NN
cord-012902-efprpk72	358	25	errors	error	NNS
cord-012902-efprpk72	358	26	.	.	.
cord-012902-efprpk72	359	1	Disclosures	disclosure	NNS
cord-012902-efprpk72	359	2	:	:	:
cord-012902-efprpk72	360	1	The	the	DT
cord-012902-efprpk72	360	2	authors	author	NNS
cord-012902-efprpk72	360	3	declared	declare	VBD
cord-012902-efprpk72	360	4	no	no	DT
cord-012902-efprpk72	360	5	conflict	conflict	NN
cord-012902-efprpk72	360	6	of	of	IN
cord-012902-efprpk72	360	7	interest	interest	NN
cord-012902-efprpk72	360	8	in	in	IN
cord-012902-efprpk72	360	9	completing	complete	VBG
cord-012902-efprpk72	360	10	this	this	DT
cord-012902-efprpk72	360	11	audit	audit	NN
cord-012902-efprpk72	360	12	.	.	.
cord-012902-efprpk72	361	1	Kadie	Kadie	NNP
cord-012902-efprpk72	361	2	-	-	HYPH
cord-012902-efprpk72	361	3	Ann	Ann	NNP
cord-012902-efprpk72	361	4	Sterling	Sterling	NNP
cord-012902-efprpk72	361	5	1	1	CD
cord-012902-efprpk72	361	6	*	*	NFP
cord-012902-efprpk72	361	7	,	,	,
cord-012902-efprpk72	361	8	Peter	Peter	NNP
cord-012902-efprpk72	361	9	Langhorne	Langhorne	NNP
cord-012902-efprpk72	361	10	2	2	CD
cord-012902-efprpk72	361	11	,	,	,
cord-012902-efprpk72	361	12	Mary	Mary	NNP
cord-012902-efprpk72	361	13	Joan	Joan	NNP
cord-012902-efprpk72	361	14	Macleod	Macleod	NNP
cord-012902-efprpk72	361	15	1	1	CD
cord-012902-efprpk72	361	16	,	,	,
cord-012902-efprpk72	361	17	Melanie	Melanie	NNP
cord-012902-efprpk72	361	18	Turner	Turner	NNP
cord-012902-efprpk72	362	1	1	1	CD
cord-012902-efprpk72	362	2	Introduction	introduction	NN
cord-012902-efprpk72	362	3	:	:	:
cord-012902-efprpk72	363	1	Hypertension	hypertension	NN
cord-012902-efprpk72	363	2	is	be	VBZ
cord-012902-efprpk72	363	3	an	an	DT
cord-012902-efprpk72	363	4	independent	independent	JJ
cord-012902-efprpk72	363	5	risk	risk	NN
cord-012902-efprpk72	363	6	factor	factor	NN
cord-012902-efprpk72	363	7	for	for	IN
cord-012902-efprpk72	363	8	both	both	CC
cord-012902-efprpk72	363	9	ischaemic	ischaemic	JJ
cord-012902-efprpk72	363	10	and	and	CC
cord-012902-efprpk72	363	11	haemorrhagic	haemorrhagic	JJ
cord-012902-efprpk72	363	12	strokes	stroke	NNS
cord-012902-efprpk72	363	13	[	[	-LRB-
cord-012902-efprpk72	363	14	1	1	CD
cord-012902-efprpk72	363	15	]	]	-RRB-
cord-012902-efprpk72	363	16	.	.	.
cord-012902-efprpk72	364	1	Adequate	adequate	JJ
cord-012902-efprpk72	364	2	management	management	NN
cord-012902-efprpk72	364	3	of	of	IN
cord-012902-efprpk72	364	4	this	this	DT
cord-012902-efprpk72	364	5	condition	condition	NN
cord-012902-efprpk72	364	6	with	with	IN
cord-012902-efprpk72	364	7	blood	blood	NN
cord-012902-efprpk72	364	8	pressurelowering	pressurelowering	NN
cord-012902-efprpk72	364	9	medications	medication	NNS
cord-012902-efprpk72	364	10	(	(	-LRB-
cord-012902-efprpk72	364	11	BPLM	BPLM	NNP
cord-012902-efprpk72	364	12	)	)	-RRB-
cord-012902-efprpk72	364	13	is	be	VBZ
cord-012902-efprpk72	364	14	essential	essential	JJ
cord-012902-efprpk72	364	15	in	in	IN
cord-012902-efprpk72	364	16	preventing	prevent	VBG
cord-012902-efprpk72	364	17	recurrent	recurrent	JJ
cord-012902-efprpk72	364	18	stroke	stroke	NN
cord-012902-efprpk72	364	19	events	event	NNS
cord-012902-efprpk72	364	20	.	.	.
cord-012902-efprpk72	365	1	This	this	DT
cord-012902-efprpk72	365	2	study	study	NN
cord-012902-efprpk72	365	3	aims	aim	VBZ
cord-012902-efprpk72	365	4	to	to	TO
cord-012902-efprpk72	365	5	investigate	investigate	VB
cord-012902-efprpk72	365	6	the	the	DT
cord-012902-efprpk72	365	7	patient	patient	NN
cord-012902-efprpk72	365	8	factors	factor	NNS
cord-012902-efprpk72	365	9	associated	associate	VBN
cord-012902-efprpk72	365	10	with	with	IN
cord-012902-efprpk72	365	11	the	the	DT
cord-012902-efprpk72	365	12	prescribing	prescribing	NN
cord-012902-efprpk72	365	13	of	of	IN
cord-012902-efprpk72	365	14	blood	blood	NN
cord-012902-efprpk72	365	15	pressure	pressure	NN
cord-012902-efprpk72	365	16	lowering	lower	VBG
cord-012902-efprpk72	365	17	medications	medication	NNS
cord-012902-efprpk72	365	18	after	after	IN
cord-012902-efprpk72	365	19	any	any	DT
cord-012902-efprpk72	365	20	index	index	NN
cord-012902-efprpk72	365	21	stroke	stroke	NN
cord-012902-efprpk72	365	22	in	in	IN
cord-012902-efprpk72	365	23	Scotland	Scotland	NNP
cord-012902-efprpk72	365	24	.	.	.
cord-012902-efprpk72	366	1	Methods	method	NNS
cord-012902-efprpk72	366	2	:	:	:
cord-012902-efprpk72	366	3	Data	datum	NNS
cord-012902-efprpk72	366	4	collected	collect	VBN
cord-012902-efprpk72	366	5	within	within	IN
cord-012902-efprpk72	366	6	the	the	DT
cord-012902-efprpk72	366	7	Scottish	Scottish	NNP
cord-012902-efprpk72	366	8	Stroke	Stroke	NNP
cord-012902-efprpk72	366	9	Care	Care	NNP
cord-012902-efprpk72	366	10	Audit	Audit	NNP
cord-012902-efprpk72	367	1	[	[	-LRB-
cord-012902-efprpk72	367	2	2	2	LS
cord-012902-efprpk72	367	3	]	]	-RRB-
cord-012902-efprpk72	367	4	Introduction	introduction	NN
cord-012902-efprpk72	367	5	:	:	:
cord-012902-efprpk72	367	6	Plasma	plasma	NN
cord-012902-efprpk72	367	7	renin	renin	NN
cord-012902-efprpk72	367	8	activity	activity	NN
cord-012902-efprpk72	367	9	(	(	-LRB-
cord-012902-efprpk72	367	10	PRA	PRA	NNP
cord-012902-efprpk72	367	11	)	)	-RRB-
cord-012902-efprpk72	367	12	is	be	VBZ
cord-012902-efprpk72	367	13	regarded	regard	VBN
cord-012902-efprpk72	367	14	as	as	IN
cord-012902-efprpk72	367	15	a	a	DT
cord-012902-efprpk72	367	16	marker	marker	NN
cord-012902-efprpk72	367	17	of	of	IN
cord-012902-efprpk72	367	18	sodium	sodium	NN
cord-012902-efprpk72	367	19	and	and	CC
cord-012902-efprpk72	367	20	fluid	fluid	JJ
cord-012902-efprpk72	367	21	homoeostasis	homoeostasis	NN
cord-012902-efprpk72	367	22	in	in	IN
cord-012902-efprpk72	367	23	patients	patient	NNS
cord-012902-efprpk72	367	24	with	with	IN
cord-012902-efprpk72	367	25	essential	essential	JJ
cord-012902-efprpk72	367	26	hypertension	hypertension	NN
cord-012902-efprpk72	367	27	,	,	,
cord-012902-efprpk72	367	28	with	with	IN
cord-012902-efprpk72	367	29	suppressed	suppress	VBN
cord-012902-efprpk72	367	30	renin	renin	NN
cord-012902-efprpk72	367	31	being	be	VBG
cord-012902-efprpk72	367	32	indicative	indicative	JJ
cord-012902-efprpk72	367	33	of	of	IN
cord-012902-efprpk72	367	34	a	a	DT
cord-012902-efprpk72	367	35	sodium	sodium	NN
cord-012902-efprpk72	367	36	retaining	retain	VBG
cord-012902-efprpk72	367	37	state	state	NN
cord-012902-efprpk72	367	38	particularly	particularly	RB
cord-012902-efprpk72	367	39	responsive	responsive	JJ
cord-012902-efprpk72	367	40	to	to	IN
cord-012902-efprpk72	367	41	treatment	treatment	NN
cord-012902-efprpk72	367	42	by	by	IN
cord-012902-efprpk72	367	43	diuretics	diuretic	NNS
cord-012902-efprpk72	367	44	.	.	.
cord-012902-efprpk72	368	1	Renin	renin	NN
cord-012902-efprpk72	368	2	has	have	VBZ
cord-012902-efprpk72	368	3	therefore	therefore	RB
cord-012902-efprpk72	368	4	been	be	VBN
cord-012902-efprpk72	368	5	proposed	propose	VBN
cord-012902-efprpk72	368	6	as	as	IN
cord-012902-efprpk72	368	7	a	a	DT
cord-012902-efprpk72	368	8	biomarker	biomarker	NN
cord-012902-efprpk72	368	9	that	that	WDT
cord-012902-efprpk72	368	10	might	may	MD
cord-012902-efprpk72	368	11	be	be	VB
cord-012902-efprpk72	368	12	used	use	VBN
cord-012902-efprpk72	368	13	to	to	TO
cord-012902-efprpk72	368	14	guide	guide	VB
cord-012902-efprpk72	368	15	diuretic	diuretic	JJ
cord-012902-efprpk72	368	16	treatment	treatment	NN
cord-012902-efprpk72	368	17	.	.	.
cord-012902-efprpk72	369	1	However	however	RB
cord-012902-efprpk72	369	2	,	,	,
cord-012902-efprpk72	369	3	whether	whether	IN
cord-012902-efprpk72	369	4	(	(	-LRB-
cord-012902-efprpk72	369	5	a	a	LS
cord-012902-efprpk72	369	6	)	)	-RRB-
cord-012902-efprpk72	369	7	diuretics	diuretic	NNS
cord-012902-efprpk72	369	8	lead	lead	VBP
cord-012902-efprpk72	369	9	to	to	IN
cord-012902-efprpk72	369	10	a	a	DT
cord-012902-efprpk72	369	11	sustained	sustained	JJ
cord-012902-efprpk72	369	12	increase	increase	NN
cord-012902-efprpk72	369	13	in	in	IN
cord-012902-efprpk72	369	14	renin	renin	NN
cord-012902-efprpk72	369	15	and	and	CC
cord-012902-efprpk72	369	16	(	(	-LRB-
cord-012902-efprpk72	369	17	b	b	NN
cord-012902-efprpk72	369	18	)	)	-RRB-
cord-012902-efprpk72	369	19	changes	change	VBZ
cord-012902-efprpk72	369	20	in	in	IN
cord-012902-efprpk72	369	21	renin	renin	NN
cord-012902-efprpk72	369	22	relate	relate	VBP
cord-012902-efprpk72	369	23	to	to	IN
cord-012902-efprpk72	369	24	those	those	DT
cord-012902-efprpk72	369	25	in	in	IN
cord-012902-efprpk72	369	26	blood	blood	NN
cord-012902-efprpk72	369	27	pressure	pressure	NN
cord-012902-efprpk72	369	28	is	be	VBZ
cord-012902-efprpk72	369	29	unknown	unknown	JJ
cord-012902-efprpk72	369	30	.	.	.
cord-012902-efprpk72	370	1	Here	here	RB
cord-012902-efprpk72	370	2	we	-PRON-	PRP
cord-012902-efprpk72	370	3	perform	perform	VBP
cord-012902-efprpk72	370	4	a	a	DT
cord-012902-efprpk72	370	5	systematic	systematic	JJ
cord-012902-efprpk72	370	6	review	review	NN
cord-012902-efprpk72	370	7	of	of	IN
cord-012902-efprpk72	370	8	trials	trial	NNS
cord-012902-efprpk72	370	9	of	of	IN
cord-012902-efprpk72	370	10	diuretic	diuretic	JJ
cord-012902-efprpk72	370	11	therapy	therapy	NN
cord-012902-efprpk72	370	12	in	in	IN
cord-012902-efprpk72	370	13	which	which	WDT
cord-012902-efprpk72	370	14	PRA	PRA	NNP
cord-012902-efprpk72	370	15	and/or	and/or	CC
cord-012902-efprpk72	370	16	other	other	JJ
cord-012902-efprpk72	370	17	biomarkers	biomarker	NNS
cord-012902-efprpk72	370	18	of	of	IN
cord-012902-efprpk72	370	19	fluid	fluid	JJ
cord-012902-efprpk72	370	20	homoeostasis	homoeostasis	NN
cord-012902-efprpk72	370	21	were	be	VBD
cord-012902-efprpk72	370	22	measured	measure	VBN
cord-012902-efprpk72	370	23	before	before	RB
cord-012902-efprpk72	370	24	and	and	CC
cord-012902-efprpk72	370	25	after	after	IN
cord-012902-efprpk72	370	26	treatment	treatment	NN
cord-012902-efprpk72	370	27	.	.	.
cord-012902-efprpk72	371	1	Methods	method	NNS
cord-012902-efprpk72	371	2	:	:	:
cord-012902-efprpk72	371	3	Three	three	CD
cord-012902-efprpk72	371	4	databases	database	NNS
cord-012902-efprpk72	371	5	were	be	VBD
cord-012902-efprpk72	371	6	searched	search	VBN
cord-012902-efprpk72	371	7	:	:	:
cord-012902-efprpk72	371	8	MEDLINE	MEDLINE	NNP
cord-012902-efprpk72	371	9	(	(	-LRB-
cord-012902-efprpk72	371	10	1946	1946	CD
cord-012902-efprpk72	371	11	to	to	IN
cord-012902-efprpk72	371	12	20th	20th	JJ
cord-012902-efprpk72	371	13	February	February	NNP
cord-012902-efprpk72	371	14	2018	2018	CD
cord-012902-efprpk72	371	15	)	)	-RRB-
cord-012902-efprpk72	371	16	,	,	,
cord-012902-efprpk72	371	17	EMBASE	EMBASE	NNP
cord-012902-efprpk72	371	18	(	(	-LRB-
cord-012902-efprpk72	371	19	1974	1974	CD
cord-012902-efprpk72	371	20	EMBASE	EMBASE	NNP
cord-012902-efprpk72	371	21	(	(	-LRB-
cord-012902-efprpk72	371	22	-2018	-2018	:
cord-012902-efprpk72	371	23	week	week	NN
cord-012902-efprpk72	371	24	12	12	CD
cord-012902-efprpk72	371	25	)	)	-RRB-
cord-012902-efprpk72	371	26	and	and	CC
cord-012902-efprpk72	371	27	The	the	DT
cord-012902-efprpk72	371	28	Cochrane	Cochrane	NNP
cord-012902-efprpk72	371	29	Central	Central	NNP
cord-012902-efprpk72	371	30	Register	Register	NNP
cord-012902-efprpk72	371	31	of	of	IN
cord-012902-efprpk72	371	32	Controlled	Controlled	NNP
cord-012902-efprpk72	371	33	Trials	Trials	NNPS
cord-012902-efprpk72	371	34	(	(	-LRB-
cord-012902-efprpk72	371	35	CENTRAL	CENTRAL	NNP
cord-012902-efprpk72	371	36	)	)	-RRB-
cord-012902-efprpk72	371	37	(	(	-LRB-
cord-012902-efprpk72	371	38	up	up	RB
cord-012902-efprpk72	371	39	to	to	IN
cord-012902-efprpk72	371	40	19th	19th	JJ
cord-012902-efprpk72	371	41	March	March	NNP
cord-012902-efprpk72	371	42	2018	2018	CD
cord-012902-efprpk72	371	43	)	)	-RRB-
cord-012902-efprpk72	371	44	.	.	.
cord-012902-efprpk72	372	1	Titles	title	NNS
cord-012902-efprpk72	372	2	were	be	VBD
cord-012902-efprpk72	372	3	firstly	firstly	RB
cord-012902-efprpk72	372	4	screened	screen	VBN
cord-012902-efprpk72	372	5	by	by	IN
cord-012902-efprpk72	372	6	title	title	NN
cord-012902-efprpk72	372	7	and	and	CC
cord-012902-efprpk72	372	8	abstract	abstract	JJ
cord-012902-efprpk72	372	9	for	for	IN
cord-012902-efprpk72	372	10	relevancy	relevancy	NN
cord-012902-efprpk72	372	11	before	before	IN
cord-012902-efprpk72	372	12	full	full	JJ
cord-012902-efprpk72	372	13	-	-	HYPH
cord-012902-efprpk72	372	14	text	text	NN
cord-012902-efprpk72	372	15	articles	article	NNS
cord-012902-efprpk72	372	16	were	be	VBD
cord-012902-efprpk72	372	17	assessed	assess	VBN
cord-012902-efprpk72	372	18	for	for	IN
cord-012902-efprpk72	372	19	eligibility	eligibility	NN
cord-012902-efprpk72	372	20	according	accord	VBG
cord-012902-efprpk72	372	21	to	to	IN
cord-012902-efprpk72	372	22	a	a	DT
cord-012902-efprpk72	372	23	pre	pre	JJ
cord-012902-efprpk72	372	24	-	-	JJ
cord-012902-efprpk72	372	25	defined	defined	JJ
cord-012902-efprpk72	372	26	inclusion	inclusion	NN
cord-012902-efprpk72	372	27	/	/	SYM
cord-012902-efprpk72	372	28	exclusion	exclusion	NN
cord-012902-efprpk72	372	29	criteria	criterion	NNS
cord-012902-efprpk72	372	30	.	.	.
cord-012902-efprpk72	373	1	Studies	study	NNS
cord-012902-efprpk72	373	2	were	be	VBD
cord-012902-efprpk72	373	3	eligible	eligible	JJ
cord-012902-efprpk72	373	4	for	for	IN
cord-012902-efprpk72	373	5	inclusion	inclusion	NN
cord-012902-efprpk72	373	6	if	if	IN
cord-012902-efprpk72	373	7	they	-PRON-	PRP
cord-012902-efprpk72	373	8	were	be	VBD
cord-012902-efprpk72	373	9	a	a	DT
cord-012902-efprpk72	373	10	randomised	randomised	JJ
cord-012902-efprpk72	373	11	controlled	control	VBN
cord-012902-efprpk72	373	12	trial	trial	NN
cord-012902-efprpk72	373	13	performed	perform	VBN
cord-012902-efprpk72	373	14	in	in	IN
cord-012902-efprpk72	373	15	hypertensive	hypertensive	JJ
cord-012902-efprpk72	373	16	human	human	JJ
cord-012902-efprpk72	373	17	subjects	subject	NNS
cord-012902-efprpk72	373	18	≥18	≥18	IN
cord-012902-efprpk72	373	19	years	year	NNS
cord-012902-efprpk72	373	20	old	old	JJ
cord-012902-efprpk72	373	21	,	,	,
cord-012902-efprpk72	373	22	examining	examine	VBG
cord-012902-efprpk72	373	23	antihypertensive	antihypertensive	JJ
cord-012902-efprpk72	373	24	effects	effect	NNS
cord-012902-efprpk72	373	25	of	of	IN
cord-012902-efprpk72	373	26	either	either	CC
cord-012902-efprpk72	373	27	a	a	DT
cord-012902-efprpk72	373	28	thiazide	thiazide	NN
cord-012902-efprpk72	373	29	,	,	,
cord-012902-efprpk72	373	30	thiazide	thiazide	NN
cord-012902-efprpk72	373	31	-	-	HYPH
cord-012902-efprpk72	373	32	like	like	JJ
cord-012902-efprpk72	373	33	,	,	,
cord-012902-efprpk72	373	34	loop	loop	NN
cord-012902-efprpk72	373	35	or	or	CC
cord-012902-efprpk72	373	36	potassium	potassium	NN
cord-012902-efprpk72	373	37	-	-	HYPH
cord-012902-efprpk72	373	38	sparing	spare	VBG
cord-012902-efprpk72	373	39	diuretic	diuretic	NN
cord-012902-efprpk72	373	40	with	with	IN
cord-012902-efprpk72	373	41	a	a	DT
cord-012902-efprpk72	373	42	duration	duration	NN
cord-012902-efprpk72	373	43	of	of	IN
cord-012902-efprpk72	373	44	at	at	RB
cord-012902-efprpk72	373	45	least	least	RBS
cord-012902-efprpk72	373	46	one	one	CD
cord-012902-efprpk72	373	47	week	week	NN
cord-012902-efprpk72	373	48	.	.	.
cord-012902-efprpk72	374	1	Results	result	NNS
cord-012902-efprpk72	374	2	:	:	:
cord-012902-efprpk72	375	1	A	a	DT
cord-012902-efprpk72	375	2	total	total	NN
cord-012902-efprpk72	375	3	of	of	IN
cord-012902-efprpk72	375	4	1684	1684	CD
cord-012902-efprpk72	375	5	articles	article	NNS
cord-012902-efprpk72	375	6	were	be	VBD
cord-012902-efprpk72	375	7	retrieved	retrieve	VBN
cord-012902-efprpk72	375	8	of	of	IN
cord-012902-efprpk72	375	9	which	which	WDT
cord-012902-efprpk72	375	10	61	61	CD
cord-012902-efprpk72	375	11	met	meet	VBD
cord-012902-efprpk72	375	12	the	the	DT
cord-012902-efprpk72	375	13	pre	pre	JJ
cord-012902-efprpk72	375	14	-	-	JJ
cord-012902-efprpk72	375	15	specified	specified	JJ
cord-012902-efprpk72	375	16	inclusion	inclusion	NN
cord-012902-efprpk72	375	17	/	/	SYM
cord-012902-efprpk72	375	18	exclusion	exclusion	NN
cord-012902-efprpk72	375	19	criteria	criterion	NNS
cord-012902-efprpk72	375	20	.	.	.
cord-012902-efprpk72	376	1	PRA	PRA	NNP
cord-012902-efprpk72	376	2	was	be	VBD
cord-012902-efprpk72	376	3	measured	measure	VBN
cord-012902-efprpk72	376	4	in	in	IN
cord-012902-efprpk72	376	5	45/61	45/61	CD
cord-012902-efprpk72	376	6	studies	study	NNS
cord-012902-efprpk72	376	7	.	.	.
cord-012902-efprpk72	377	1	Diuretics	diuretic	NNS
cord-012902-efprpk72	377	2	lead	lead	VBP
cord-012902-efprpk72	377	3	to	to	IN
cord-012902-efprpk72	377	4	a	a	DT
cord-012902-efprpk72	377	5	sustained	sustained	JJ
cord-012902-efprpk72	377	6	in	in	IN
cord-012902-efprpk72	377	7	increase	increase	NN
cord-012902-efprpk72	377	8	in	in	IN
cord-012902-efprpk72	377	9	PRA	PRA	NNP
cord-012902-efprpk72	377	10	.	.	.
cord-012902-efprpk72	378	1	The	the	DT
cord-012902-efprpk72	378	2	increase	increase	NN
cord-012902-efprpk72	378	3	in	in	IN
cord-012902-efprpk72	378	4	PRA	PRA	NNP
cord-012902-efprpk72	378	5	was	be	VBD
cord-012902-efprpk72	378	6	related	relate	VBN
cord-012902-efprpk72	378	7	to	to	IN
cord-012902-efprpk72	378	8	the	the	DT
cord-012902-efprpk72	378	9	decrease	decrease	NN
cord-012902-efprpk72	378	10	in	in	IN
cord-012902-efprpk72	378	11	blood	blood	NN
cord-012902-efprpk72	378	12	pressure	pressure	NN
cord-012902-efprpk72	378	13	(	(	-LRB-
cord-012902-efprpk72	378	14	β	β	NN
cord-012902-efprpk72	378	15	=	=	SYM
cord-012902-efprpk72	378	16	−0.363	−0.363	NNP
cord-012902-efprpk72	378	17	,	,	,
cord-012902-efprpk72	378	18	p	p	NN
cord-012902-efprpk72	378	19	<	<	XX
cord-012902-efprpk72	378	20	0.05	0.05	CD
cord-012902-efprpk72	378	21	)	)	-RRB-
cord-012902-efprpk72	378	22	and	and	CC
cord-012902-efprpk72	378	23	did	do	VBD
cord-012902-efprpk72	378	24	not	not	RB
cord-012902-efprpk72	378	25	differ	differ	VB
cord-012902-efprpk72	378	26	according	accord	VBG
cord-012902-efprpk72	378	27	to	to	IN
cord-012902-efprpk72	378	28	class	class	NN
cord-012902-efprpk72	378	29	of	of	IN
cord-012902-efprpk72	378	30	diuretic	diuretic	NN
cord-012902-efprpk72	378	31	.	.	.
cord-012902-efprpk72	379	1	Conclusions	conclusion	NNS
cord-012902-efprpk72	379	2	:	:	:
cord-012902-efprpk72	380	1	These	these	DT
cord-012902-efprpk72	380	2	results	result	NNS
cord-012902-efprpk72	380	3	are	be	VBP
cord-012902-efprpk72	380	4	consistent	consistent	JJ
cord-012902-efprpk72	380	5	with	with	IN
cord-012902-efprpk72	380	6	the	the	DT
cord-012902-efprpk72	380	7	reduction	reduction	NN
cord-012902-efprpk72	380	8	in	in	IN
cord-012902-efprpk72	380	9	blood	blood	NN
cord-012902-efprpk72	380	10	pressure	pressure	NN
cord-012902-efprpk72	380	11	being	be	VBG
cord-012902-efprpk72	380	12	related	relate	VBN
cord-012902-efprpk72	380	13	to	to	IN
cord-012902-efprpk72	380	14	that	that	DT
cord-012902-efprpk72	380	15	in	in	IN
cord-012902-efprpk72	380	16	body	body	NN
cord-012902-efprpk72	380	17	sodium	sodium	NN
cord-012902-efprpk72	380	18	and	and	CC
cord-012902-efprpk72	380	19	volume	volume	NN
cord-012902-efprpk72	380	20	and	and	CC
cord-012902-efprpk72	380	21	support	support	VBP
cord-012902-efprpk72	380	22	the	the	DT
cord-012902-efprpk72	380	23	use	use	NN
cord-012902-efprpk72	380	24	of	of	IN
cord-012902-efprpk72	380	25	PRA	PRA	NNP
cord-012902-efprpk72	380	26	to	to	TO
cord-012902-efprpk72	380	27	guide	guide	VB
cord-012902-efprpk72	380	28	diuretic	diuretic	JJ
cord-012902-efprpk72	380	29	therapy	therapy	NN
cord-012902-efprpk72	380	30	.	.	.
cord-012902-efprpk72	381	1	Disclosures	disclosure	NNS
cord-012902-efprpk72	381	2	:	:	:
cord-012902-efprpk72	381	3	None	none	NN
cord-012902-efprpk72	381	4	.	.	.
cord-012902-efprpk72	382	1	Introduction	introduction	NN
cord-012902-efprpk72	382	2	:	:	:
cord-012902-efprpk72	383	1	Barbershops	barbershop	NNS
cord-012902-efprpk72	383	2	as	as	IN
cord-012902-efprpk72	383	3	a	a	DT
cord-012902-efprpk72	383	4	contact	contact	NN
cord-012902-efprpk72	383	5	platform	platform	NN
cord-012902-efprpk72	383	6	to	to	TO
cord-012902-efprpk72	383	7	engage	engage	VB
cord-012902-efprpk72	383	8	with	with	IN
cord-012902-efprpk72	383	9	patients	patient	NNS
cord-012902-efprpk72	383	10	on	on	IN
cord-012902-efprpk72	383	11	a	a	DT
cord-012902-efprpk72	383	12	regular	regular	JJ
cord-012902-efprpk72	383	13	basis	basis	NN
cord-012902-efprpk72	383	14	is	be	VBZ
cord-012902-efprpk72	383	15	a	a	DT
cord-012902-efprpk72	383	16	unique	unique	JJ
cord-012902-efprpk72	383	17	approach	approach	NN
cord-012902-efprpk72	383	18	.	.	.
cord-012902-efprpk72	384	1	to	to	TO
cord-012902-efprpk72	384	2	manage	manage	VB
cord-012902-efprpk72	384	3	hypertension	hypertension	NN
cord-012902-efprpk72	384	4	.	.	.
cord-012902-efprpk72	385	1	We	-PRON-	PRP
cord-012902-efprpk72	385	2	explored	explore	VBD
cord-012902-efprpk72	385	3	evidence	evidence	NN
cord-012902-efprpk72	385	4	for	for	IN
cord-012902-efprpk72	385	5	contemporary	contemporary	JJ
cord-012902-efprpk72	385	6	role	role	NN
cord-012902-efprpk72	385	7	of	of	IN
cord-012902-efprpk72	385	8	barbershop	barbershop	NN
cord-012902-efprpk72	385	9	led	lead	VBD
cord-012902-efprpk72	385	10	interventions	intervention	NNS
cord-012902-efprpk72	385	11	to	to	TO
cord-012902-efprpk72	385	12	manage	manage	VB
cord-012902-efprpk72	385	13	hypertension	hypertension	NN
cord-012902-efprpk72	385	14	in	in	IN
cord-012902-efprpk72	385	15	community	community	NN
cord-012902-efprpk72	385	16	setting	setting	NN
cord-012902-efprpk72	385	17	,	,	,
cord-012902-efprpk72	385	18	by	by	IN
cord-012902-efprpk72	385	19	only	only	RB
cord-012902-efprpk72	385	20	including	include	VBG
cord-012902-efprpk72	385	21	randomised	randomised	JJ
cord-012902-efprpk72	385	22	controlled	control	VBN
cord-012902-efprpk72	385	23	clinical	clinical	JJ
cord-012902-efprpk72	385	24	trials	trial	NNS
cord-012902-efprpk72	385	25	(	(	-LRB-
cord-012902-efprpk72	385	26	RCCTs	rcct	NNS
cord-012902-efprpk72	385	27	)	)	-RRB-
cord-012902-efprpk72	385	28	Methods	method	NNS
cord-012902-efprpk72	385	29	:	:	:
cord-012902-efprpk72	385	30	We	-PRON-	PRP
cord-012902-efprpk72	385	31	searched	search	VBD
cord-012902-efprpk72	385	32	Cochrane	Cochrane	NNP
cord-012902-efprpk72	385	33	Library	Library	NNP
cord-012902-efprpk72	385	34	,	,	,
cord-012902-efprpk72	385	35	pubmed	pubmed	NNP
cord-012902-efprpk72	385	36	-	-	HYPH
cord-012902-efprpk72	385	37	MEDLINE	MEDLINE	NNP
cord-012902-efprpk72	385	38	,	,	,
cord-012902-efprpk72	385	39	IndMED	indme	VBZ
cord-012902-efprpk72	385	40	online	online	JJ
cord-012902-efprpk72	385	41	databases	database	NNS
cord-012902-efprpk72	385	42	to	to	TO
cord-012902-efprpk72	385	43	conduct	conduct	VB
cord-012902-efprpk72	385	44	a	a	DT
cord-012902-efprpk72	385	45	systematic	systematic	JJ
cord-012902-efprpk72	385	46	review	review	NN
cord-012902-efprpk72	385	47	of	of	IN
cord-012902-efprpk72	385	48	published	publish	VBN
cord-012902-efprpk72	385	49	RCCTs	rcct	NNS
cord-012902-efprpk72	385	50	.	.	.
cord-012902-efprpk72	386	1	Studies	study	NNS
cord-012902-efprpk72	386	2	with	with	IN
cord-012902-efprpk72	386	3	non	non	JJ
cord-012902-efprpk72	386	4	-	-	JJ
cord-012902-efprpk72	386	5	barbershop	barbershop	JJ
cord-012902-efprpk72	386	6	led	lead	VBN
cord-012902-efprpk72	386	7	,	,	,
cord-012902-efprpk72	386	8	generalised	generalised	JJ
cord-012902-efprpk72	386	9	community	community	NN
cord-012902-efprpk72	386	10	-	-	HYPH
cord-012902-efprpk72	386	11	based	base	VBN
cord-012902-efprpk72	386	12	setting	setting	NN
cord-012902-efprpk72	386	13	approaches	approach	NNS
cord-012902-efprpk72	386	14	were	be	VBD
cord-012902-efprpk72	386	15	excluded	exclude	VBN
cord-012902-efprpk72	386	16	by	by	IN
cord-012902-efprpk72	386	17	using	use	VBG
cord-012902-efprpk72	386	18	Boolean	boolean	JJ
cord-012902-efprpk72	386	19	operators	operator	NNS
cord-012902-efprpk72	386	20	Results	result	NNS
cord-012902-efprpk72	386	21	:	:	:
cord-012902-efprpk72	386	22	The	the	DT
cord-012902-efprpk72	386	23	results	result	NNS
cord-012902-efprpk72	386	24	yielded	yield	VBD
cord-012902-efprpk72	386	25	four	four	CD
cord-012902-efprpk72	386	26	clinical	clinical	JJ
cord-012902-efprpk72	386	27	trials	trial	NNS
cord-012902-efprpk72	386	28	of	of	IN
cord-012902-efprpk72	386	29	which	which	WDT
cord-012902-efprpk72	386	30	three	three	CD
cord-012902-efprpk72	386	31	met	meet	VBD
cord-012902-efprpk72	386	32	inclusion	inclusion	NN
cord-012902-efprpk72	386	33	criteria	criterion	NNS
cord-012902-efprpk72	386	34	,	,	,
cord-012902-efprpk72	386	35	published	publish	VBN
cord-012902-efprpk72	386	36	over	over	IN
cord-012902-efprpk72	386	37	last	last	JJ
cord-012902-efprpk72	386	38	10	10	CD
cord-012902-efprpk72	386	39	years	year	NNS
cord-012902-efprpk72	386	40	(	(	-LRB-
cord-012902-efprpk72	386	41	2011	2011	CD
cord-012902-efprpk72	386	42	-	-	SYM
cord-012902-efprpk72	386	43	2019	2019	CD
cord-012902-efprpk72	386	44	)	)	-RRB-
cord-012902-efprpk72	386	45	.	.	.
cord-012902-efprpk72	387	1	The	the	DT
cord-012902-efprpk72	387	2	parameters	parameter	NNS
cord-012902-efprpk72	387	3	were	be	VBD
cord-012902-efprpk72	387	4	analysed	analyse	VBN
cord-012902-efprpk72	387	5	for	for	IN
cord-012902-efprpk72	387	6	study	study	NN
cord-012902-efprpk72	387	7	design	design	NN
cord-012902-efprpk72	387	8	,	,	,
cord-012902-efprpk72	387	9	patient	patient	JJ
cord-012902-efprpk72	387	10	characteristics	characteristic	NNS
cord-012902-efprpk72	387	11	,	,	,
cord-012902-efprpk72	387	12	impact	impact	NN
cord-012902-efprpk72	387	13	factor	factor	NN
cord-012902-efprpk72	387	14	of	of	IN
cord-012902-efprpk72	387	15	journals	journal	NNS
cord-012902-efprpk72	387	16	,	,	,
cord-012902-efprpk72	387	17	duration	duration	NN
cord-012902-efprpk72	387	18	,	,	,
cord-012902-efprpk72	387	19	and	and	CC
cord-012902-efprpk72	387	20	outcomes	outcome	NNS
cord-012902-efprpk72	387	21	.	.	.
cord-012902-efprpk72	388	1	Cumulatively	cumulatively	RB
cord-012902-efprpk72	388	2	,	,	,
cord-012902-efprpk72	388	3	1826	1826	CD
cord-012902-efprpk72	388	4	subjects	subject	NNS
cord-012902-efprpk72	388	5	(	(	-LRB-
cord-012902-efprpk72	388	6	mean	mean	VB
cord-012902-efprpk72	388	7	609	609	CD
cord-012902-efprpk72	388	8	subjects	subject	NNS
cord-012902-efprpk72	388	9	,	,	,
cord-012902-efprpk72	388	10	SD	SD	NNP
cord-012902-efprpk72	388	11	±	±	NNP
cord-012902-efprpk72	388	12	367	367	CD
cord-012902-efprpk72	388	13	,	,	,
cord-012902-efprpk72	388	14	SEM	SEM	NNP
cord-012902-efprpk72	388	15	±	±	NNP
cord-012902-efprpk72	388	16	212	212	CD
cord-012902-efprpk72	388	17	,	,	,
cord-012902-efprpk72	388	18	minimum	minimum	JJ
cord-012902-efprpk72	388	19	319	319	CD
cord-012902-efprpk72	388	20	,	,	,
cord-012902-efprpk72	388	21	maximum	maximum	JJ
cord-012902-efprpk72	388	22	1022	1022	CD
cord-012902-efprpk72	388	23	,	,	,
cord-012902-efprpk72	388	24	95	95	CD
cord-012902-efprpk72	388	25	%	%	NN
cord-012902-efprpk72	388	26	CI	CI	NNP
cord-012902-efprpk72	388	27	−304	−304	NNP
cord-012902-efprpk72	388	28	to	to	IN
cord-012902-efprpk72	388	29	1521	1521	CD
cord-012902-efprpk72	388	30	,	,	,
cord-012902-efprpk72	388	31	p	p	NN
cord-012902-efprpk72	388	32	=	=	SYM
cord-012902-efprpk72	388	33	0.103	0.103	CD
cord-012902-efprpk72	388	34	NS	NS	NNP
cord-012902-efprpk72	388	35	)	)	-RRB-
cord-012902-efprpk72	388	36	have	have	VBP
cord-012902-efprpk72	388	37	been	be	VBN
cord-012902-efprpk72	388	38	evaluated	evaluate	VBN
cord-012902-efprpk72	388	39	across	across	IN
cord-012902-efprpk72	388	40	three	three	CD
cord-012902-efprpk72	388	41	RCCTs	rcct	NNS
cord-012902-efprpk72	388	42	.	.	.
cord-012902-efprpk72	389	1	Cumulative	cumulative	JJ
cord-012902-efprpk72	389	2	duration	duration	NN
cord-012902-efprpk72	389	3	of	of	IN
cord-012902-efprpk72	389	4	the	the	DT
cord-012902-efprpk72	389	5	trials	trial	NNS
cord-012902-efprpk72	389	6	was	be	VBD
cord-012902-efprpk72	389	7	32	32	CD
cord-012902-efprpk72	389	8	months	month	NNS
cord-012902-efprpk72	389	9	(	(	-LRB-
cord-012902-efprpk72	389	10	mean	mean	VBP
cord-012902-efprpk72	389	11	11	11	CD
cord-012902-efprpk72	389	12	months	month	NNS
cord-012902-efprpk72	389	13	,	,	,
cord-012902-efprpk72	389	14	SD	SD	NNP
cord-012902-efprpk72	389	15	±	±	NNP
cord-012902-efprpk72	389	16	1.2	1.2	CD
cord-012902-efprpk72	389	17	,	,	,
cord-012902-efprpk72	389	18	SEM	SEM	NNP
cord-012902-efprpk72	389	19	±	±	NNP
cord-012902-efprpk72	389	20	0.67	0.67	CD
cord-012902-efprpk72	389	21	,	,	,
cord-012902-efprpk72	389	22	minimum	minimum	JJ
cord-012902-efprpk72	389	23	10	10	CD
cord-012902-efprpk72	389	24	,	,	,
cord-012902-efprpk72	389	25	maximum	maximum	JJ
cord-012902-efprpk72	389	26	12	12	CD
cord-012902-efprpk72	389	27	,	,	,
cord-012902-efprpk72	389	28	95	95	CD
cord-012902-efprpk72	389	29	%	%	NN
cord-012902-efprpk72	389	30	CI	CI	NNP
cord-012902-efprpk72	389	31	7.8	7.8	CD
cord-012902-efprpk72	389	32	to	to	IN
cord-012902-efprpk72	389	33	13.5	13.5	CD
cord-012902-efprpk72	389	34	,	,	,
cord-012902-efprpk72	389	35	p	p	NN
cord-012902-efprpk72	389	36	=	=	SYM
cord-012902-efprpk72	389	37	0.0039	0.0039	CD
cord-012902-efprpk72	389	38	)	)	-RRB-
cord-012902-efprpk72	389	39	.	.	.
cord-012902-efprpk72	390	1	The	the	DT
cord-012902-efprpk72	390	2	baseline	baseline	JJ
cord-012902-efprpk72	390	3	systolic	systolic	JJ
cord-012902-efprpk72	390	4	BP	BP	NNP
cord-012902-efprpk72	390	5	of	of	IN
cord-012902-efprpk72	390	6	≥140	≥140	``
cord-012902-efprpk72	390	7	mmHg	mmHg	NNP
cord-012902-efprpk72	390	8	has	have	VBZ
cord-012902-efprpk72	390	9	been	be	VBN
cord-012902-efprpk72	390	10	uniform	uniform	JJ
cord-012902-efprpk72	390	11	enrolment	enrolment	NN
cord-012902-efprpk72	390	12	criteria	criterion	NNS
cord-012902-efprpk72	390	13	.	.	.
cord-012902-efprpk72	391	1	Based	base	VBN
cord-012902-efprpk72	391	2	on	on	IN
cord-012902-efprpk72	391	3	impact	impact	NN
cord-012902-efprpk72	391	4	factor	factor	NN
cord-012902-efprpk72	391	5	of	of	IN
cord-012902-efprpk72	391	6	the	the	DT
cord-012902-efprpk72	391	7	journals	journal	NNS
cord-012902-efprpk72	391	8	(	(	-LRB-
cord-012902-efprpk72	391	9	mean	mean	NNP
cord-012902-efprpk72	391	10	31	31	CD
cord-012902-efprpk72	391	11	,	,	,
cord-012902-efprpk72	391	12	SD	SD	NNP
cord-012902-efprpk72	391	13	±	±	NNP
cord-012902-efprpk72	391	14	35	35	CD
cord-012902-efprpk72	391	15	,	,	,
cord-012902-efprpk72	391	16	SEM	SEM	NNP
cord-012902-efprpk72	391	17	±	±	NNP
cord-012902-efprpk72	391	18	20	20	CD
cord-012902-efprpk72	391	19	,	,	,
cord-012902-efprpk72	391	20	minimum	minimum	JJ
cord-012902-efprpk72	391	21	2.8	2.8	CD
cord-012902-efprpk72	391	22	,	,	,
cord-012902-efprpk72	391	23	maximum	maximum	VB
cord-012902-efprpk72	391	24	71	71	CD
cord-012902-efprpk72	391	25	,	,	,
cord-012902-efprpk72	391	26	95	95	CD
cord-012902-efprpk72	391	27	%	%	NN
cord-012902-efprpk72	391	28	CI	CI	NNP
cord-012902-efprpk72	391	29	−56	−56	NNP
cord-012902-efprpk72	391	30	to	to	IN
cord-012902-efprpk72	391	31	119	119	CD
cord-012902-efprpk72	391	32	;	;	:
cord-012902-efprpk72	391	33	p	p	NN
cord-012902-efprpk72	391	34	=	=	SYM
cord-012902-efprpk72	391	35	0.26	0.26	CD
cord-012902-efprpk72	391	36	NS	NS	NNP
cord-012902-efprpk72	391	37	)	)	-RRB-
cord-012902-efprpk72	391	38	,	,	,
cord-012902-efprpk72	391	39	we	-PRON-	PRP
cord-012902-efprpk72	391	40	formulated	formulate	VBD
cord-012902-efprpk72	391	41	an	an	DT
cord-012902-efprpk72	391	42	indexed	index	VBN
cord-012902-efprpk72	391	43	weightage	weightage	NN
cord-012902-efprpk72	391	44	score	score	NN
cord-012902-efprpk72	391	45	(	(	-LRB-
cord-012902-efprpk72	391	46	mean	mean	VB
cord-012902-efprpk72	391	47	100	100	CD
cord-012902-efprpk72	391	48	,	,	,
cord-012902-efprpk72	391	49	minimum	minimum	JJ
cord-012902-efprpk72	391	50	9	9	CD
cord-012902-efprpk72	391	51	,	,	,
cord-012902-efprpk72	391	52	maximum	maximum	JJ
cord-012902-efprpk72	391	53	225	225	CD
cord-012902-efprpk72	391	54	,	,	,
cord-012902-efprpk72	391	55	SD	SD	NNP
cord-012902-efprpk72	391	56	±	±	NNP
cord-012902-efprpk72	391	57	112	112	CD
cord-012902-efprpk72	391	58	,	,	,
cord-012902-efprpk72	391	59	SEM	SEM	NNP
cord-012902-efprpk72	391	60	±	±	NNP
cord-012902-efprpk72	391	61	65	65	CD
cord-012902-efprpk72	391	62	,	,	,
cord-012902-efprpk72	391	63	95	95	CD
cord-012902-efprpk72	391	64	%	%	NN
cord-012902-efprpk72	391	65	CI	CI	NNP
cord-012902-efprpk72	391	66	−178	−178	NNP
cord-012902-efprpk72	391	67	to	to	IN
cord-012902-efprpk72	391	68	378	378	CD
cord-012902-efprpk72	391	69	,	,	,
cord-012902-efprpk72	391	70	p	p	NN
cord-012902-efprpk72	391	71	=	=	SYM
cord-012902-efprpk72	391	72	0.26	0.26	CD
cord-012902-efprpk72	391	73	NS	NS	NNP
cord-012902-efprpk72	391	74	)	)	-RRB-
cord-012902-efprpk72	391	75	.	.	.
cord-012902-efprpk72	392	1	Patients	patient	NNS
cord-012902-efprpk72	392	2	who	who	WP
cord-012902-efprpk72	392	3	were	be	VBD
cord-012902-efprpk72	392	4	treated	treat	VBN
cord-012902-efprpk72	392	5	with	with	IN
cord-012902-efprpk72	392	6	specialists	specialist	NNS
cord-012902-efprpk72	392	7	,	,	,
cord-012902-efprpk72	392	8	received	receive	VBD
cord-012902-efprpk72	392	9	more	more	JJR
cord-012902-efprpk72	392	10	BP	BP	NNP
cord-012902-efprpk72	392	11	medication	medication	NN
cord-012902-efprpk72	392	12	and	and	CC
cord-012902-efprpk72	392	13	different	different	JJ
cord-012902-efprpk72	392	14	classes	class	NNS
cord-012902-efprpk72	392	15	of	of	IN
cord-012902-efprpk72	392	16	medication	medication	NN
cord-012902-efprpk72	392	17	than	than	IN
cord-012902-efprpk72	392	18	those	those	DT
cord-012902-efprpk72	392	19	treated	treat	VBN
cord-012902-efprpk72	392	20	by	by	IN
cord-012902-efprpk72	392	21	primary	primary	JJ
cord-012902-efprpk72	392	22	care	care	NN
cord-012902-efprpk72	392	23	physicians	physician	NNS
cord-012902-efprpk72	392	24	and	and	CC
cord-012902-efprpk72	392	25	BP	BP	NNP
cord-012902-efprpk72	392	26	reduction	reduction	NN
cord-012902-efprpk72	392	27	was	be	VBD
cord-012902-efprpk72	392	28	21	21	CD
cord-012902-efprpk72	392	29	mmHg	mmHg	NNS
cord-012902-efprpk72	392	30	(	(	-LRB-
cord-012902-efprpk72	392	31	p	p	NN
cord-012902-efprpk72	392	32	<	<	XX
cord-012902-efprpk72	392	33	0.0001	0.0001	CD
cord-012902-efprpk72	392	34	)	)	-RRB-
cord-012902-efprpk72	392	35	Conclusions	conclusion	NNS
cord-012902-efprpk72	392	36	:	:	:
cord-012902-efprpk72	393	1	Barber	Barber	NNP
cord-012902-efprpk72	393	2	based	base	VBN
cord-012902-efprpk72	393	3	intervention	intervention	NN
cord-012902-efprpk72	393	4	model	model	NN
cord-012902-efprpk72	393	5	have	have	VBP
cord-012902-efprpk72	393	6	demonstrated	demonstrate	VBN
cord-012902-efprpk72	393	7	to	to	TO
cord-012902-efprpk72	393	8	be	be	VB
cord-012902-efprpk72	393	9	a	a	DT
cord-012902-efprpk72	393	10	feasible	feasible	JJ
cord-012902-efprpk72	393	11	connect	connect	NN
cord-012902-efprpk72	393	12	between	between	IN
cord-012902-efprpk72	393	13	the	the	DT
cord-012902-efprpk72	393	14	patients	patient	NNS
cord-012902-efprpk72	393	15	and	and	CC
cord-012902-efprpk72	393	16	healthcare	healthcare	NN
cord-012902-efprpk72	393	17	providers	provider	NNS
cord-012902-efprpk72	393	18	resulting	result	VBG
cord-012902-efprpk72	393	19	in	in	IN
cord-012902-efprpk72	393	20	sustained	sustained	JJ
cord-012902-efprpk72	393	21	BP	BP	NNP
cord-012902-efprpk72	393	22	reductions	reduction	NNS
cord-012902-efprpk72	393	23	in	in	IN
cord-012902-efprpk72	393	24	the	the	DT
cord-012902-efprpk72	393	25	community	community	NN
cord-012902-efprpk72	393	26	,	,	,
cord-012902-efprpk72	393	27	especially	especially	RB
cord-012902-efprpk72	393	28	when	when	WRB
cord-012902-efprpk72	393	29	care	care	VBP
cord-012902-efprpk72	393	30	linkage	linkage	NN
cord-012902-efprpk72	393	31	to	to	IN
cord-012902-efprpk72	393	32	hypertension	hypertension	NN
cord-012902-efprpk72	393	33	specialists	specialist	NNS
cord-012902-efprpk72	393	34	can	can	MD
cord-012902-efprpk72	393	35	be	be	VB
cord-012902-efprpk72	393	36	achieved	achieve	VBN
cord-012902-efprpk72	393	37	.	.	.
cord-012902-efprpk72	394	1	Disclosures	disclosure	NNS
cord-012902-efprpk72	394	2	:	:	:
cord-012902-efprpk72	394	3	None	none	NN
cord-012902-efprpk72	394	4	.	.	.
cord-012902-efprpk72	395	1	Introduction	introduction	NN
cord-012902-efprpk72	395	2	:	:	:
cord-012902-efprpk72	395	3	Hypertension	hypertension	NN
cord-012902-efprpk72	395	4	after	after	IN
cord-012902-efprpk72	395	5	successful	successful	JJ
cord-012902-efprpk72	395	6	kidney	kidney	NN
cord-012902-efprpk72	395	7	transplantation	transplantation	NN
cord-012902-efprpk72	395	8	(	(	-LRB-
cord-012902-efprpk72	395	9	KT	KT	NNP
cord-012902-efprpk72	395	10	)	)	-RRB-
cord-012902-efprpk72	395	11	is	be	VBZ
cord-012902-efprpk72	395	12	associated	associate	VBN
cord-012902-efprpk72	395	13	with	with	IN
cord-012902-efprpk72	395	14	poor	poor	JJ
cord-012902-efprpk72	395	15	renal	renal	JJ
cord-012902-efprpk72	395	16	allograft	allograft	NN
cord-012902-efprpk72	395	17	outcomes	outcome	NNS
cord-012902-efprpk72	395	18	.	.	.
cord-012902-efprpk72	396	1	Although	although	IN
cord-012902-efprpk72	396	2	,	,	,
cord-012902-efprpk72	396	3	Association	Association	NNP
cord-012902-efprpk72	396	4	visit	visit	NN
cord-012902-efprpk72	396	5	-	-	HYPH
cord-012902-efprpk72	396	6	to	to	IN
cord-012902-efprpk72	396	7	-	-	HYPH
cord-012902-efprpk72	396	8	visit	visit	NN
cord-012902-efprpk72	396	9	variability	variability	NN
cord-012902-efprpk72	396	10	of	of	IN
cord-012902-efprpk72	396	11	cholesterol	cholesterol	NN
cord-012902-efprpk72	396	12	and	and	CC
cord-012902-efprpk72	396	13	blood	blood	NN
cord-012902-efprpk72	396	14	pressure	pressure	NN
cord-012902-efprpk72	396	15	(	(	-LRB-
cord-012902-efprpk72	396	16	BP	BP	NNP
cord-012902-efprpk72	396	17	)	)	-RRB-
cord-012902-efprpk72	396	18	is	be	VBZ
cord-012902-efprpk72	396	19	associated	associate	VBN
cord-012902-efprpk72	396	20	with	with	IN
cord-012902-efprpk72	396	21	cardiovascular	cardiovascular	JJ
cord-012902-efprpk72	396	22	risk	risk	NN
cord-012902-efprpk72	396	23	[	[	-LRB-
cord-012902-efprpk72	396	24	1	1	CD
cord-012902-efprpk72	396	25	]	]	-RRB-
cord-012902-efprpk72	396	26	[	[	-LRB-
cord-012902-efprpk72	396	27	2	2	CD
cord-012902-efprpk72	396	28	]	]	-RRB-
cord-012902-efprpk72	396	29	[	[	-LRB-
cord-012902-efprpk72	396	30	3	3	CD
cord-012902-efprpk72	396	31	]	]	-RRB-
cord-012902-efprpk72	396	32	.	.	.
cord-012902-efprpk72	397	1	Association	association	NN
cord-012902-efprpk72	397	2	between	between	IN
cord-012902-efprpk72	397	3	visit	visit	NN
cord-012902-efprpk72	397	4	-	-	HYPH
cord-012902-efprpk72	397	5	to	to	IN
cord-012902-efprpk72	397	6	-	-	HYPH
cord-012902-efprpk72	397	7	visit	visit	NN
cord-012902-efprpk72	397	8	BP	BP	NNP
cord-012902-efprpk72	397	9	variability	variability	NN
cord-012902-efprpk72	397	10	(	(	-LRB-
cord-012902-efprpk72	397	11	VVBPV	VVBPV	NNP
cord-012902-efprpk72	397	12	)	)	-RRB-
cord-012902-efprpk72	397	13	and	and	CC
cord-012902-efprpk72	397	14	renal	renal	JJ
cord-012902-efprpk72	397	15	allograft	allograft	NN
cord-012902-efprpk72	397	16	outcomes	outcome	NNS
cord-012902-efprpk72	397	17	is	be	VBZ
cord-012902-efprpk72	397	18	unknown	unknown	JJ
cord-012902-efprpk72	397	19	.	.	.
cord-012902-efprpk72	398	1	Methods	method	NNS
cord-012902-efprpk72	398	2	:	:	:
cord-012902-efprpk72	398	3	VVBPV	VVBPV	NNP
cord-012902-efprpk72	398	4	from	from	IN
cord-012902-efprpk72	398	5	BP	BP	NNP
cord-012902-efprpk72	398	6	measurements	measurement	NNS
cord-012902-efprpk72	398	7	at	at	IN
cord-012902-efprpk72	398	8	4	4	CD
cord-012902-efprpk72	398	9	,	,	,
cord-012902-efprpk72	398	10	12	12	CD
cord-012902-efprpk72	398	11	,	,	,
cord-012902-efprpk72	398	12	24	24	CD
cord-012902-efprpk72	398	13	,	,	,
cord-012902-efprpk72	398	14	36	36	CD
cord-012902-efprpk72	398	15	,	,	,
cord-012902-efprpk72	398	16	and	and	CC
cord-012902-efprpk72	399	1	48	48	CD
cord-012902-efprpk72	399	2	weeks	week	NNS
cord-012902-efprpk72	399	3	post	post	NN
cord-012902-efprpk72	399	4	-	-	NN
cord-012902-efprpk72	399	5	KT	KT	NNP
cord-012902-efprpk72	399	6	was	be	VBD
cord-012902-efprpk72	399	7	assessed	assess	VBN
cord-012902-efprpk72	399	8	with	with	IN
cord-012902-efprpk72	399	9	3	3	CD
cord-012902-efprpk72	399	10	methods	method	NNS
cord-012902-efprpk72	399	11	:	:	:
cord-012902-efprpk72	399	12	1	1	CD
cord-012902-efprpk72	399	13	.	.	.
cord-012902-efprpk72	400	1	Standard	standard	JJ
cord-012902-efprpk72	400	2	deviation	deviation	NN
cord-012902-efprpk72	400	3	(	(	-LRB-
cord-012902-efprpk72	400	4	SD	sd	NN
cord-012902-efprpk72	400	5	)	)	-RRB-
cord-012902-efprpk72	400	6	of	of	IN
cord-012902-efprpk72	400	7	BP	BP	NNP
cord-012902-efprpk72	400	8	2	2	CD
cord-012902-efprpk72	400	9	.	.	.
cord-012902-efprpk72	401	1	Coefficient	coefficient	NN
cord-012902-efprpk72	401	2	of	of	IN
cord-012902-efprpk72	401	3	variation	variation	NN
cord-012902-efprpk72	401	4	(	(	-LRB-
cord-012902-efprpk72	401	5	CV	cv	NN
cord-012902-efprpk72	401	6	=	=	SYM
cord-012902-efprpk72	401	7	SD	SD	NNP
cord-012902-efprpk72	401	8	/	/	SYM
cord-012902-efprpk72	401	9	Mean	Mean	NNP
cord-012902-efprpk72	401	10	×	×	NN
cord-012902-efprpk72	401	11	100	100	CD
cord-012902-efprpk72	401	12	%	%	NN
cord-012902-efprpk72	401	13	)	)	-RRB-
cord-012902-efprpk72	401	14	3	3	CD
cord-012902-efprpk72	401	15	.	.	.
cord-012902-efprpk72	402	1	Average	average	JJ
cord-012902-efprpk72	402	2	successive	successive	JJ
cord-012902-efprpk72	402	3	variability	variability	NN
cord-012902-efprpk72	402	4	(	(	-LRB-
cord-012902-efprpk72	402	5	ASV	ASV	NNP
cord-012902-efprpk72	402	6	=	=	NFP
cord-012902-efprpk72	402	7	the	the	DT
cord-012902-efprpk72	402	8	average	average	JJ
cord-012902-efprpk72	402	9	absolute	absolute	JJ
cord-012902-efprpk72	402	10	difference	difference	NN
cord-012902-efprpk72	402	11	between	between	IN
cord-012902-efprpk72	402	12	successive	successive	JJ
cord-012902-efprpk72	402	13	values	value	NNS
cord-012902-efprpk72	402	14	.	.	.
cord-012902-efprpk72	403	1	Multi	multi	JJ
cord-012902-efprpk72	403	2	-	-	JJ
cord-012902-efprpk72	403	3	variable	variable	JJ
cord-012902-efprpk72	403	4	Cox	Cox	NNP
cord-012902-efprpk72	403	5	proportional	proportional	JJ
cord-012902-efprpk72	403	6	hazard	hazard	NN
cord-012902-efprpk72	403	7	regression	regression	NN
cord-012902-efprpk72	403	8	analysis	analysis	NN
cord-012902-efprpk72	403	9	was	be	VBD
cord-012902-efprpk72	403	10	used	use	VBN
cord-012902-efprpk72	403	11	to	to	TO
cord-012902-efprpk72	403	12	examine	examine	VB
cord-012902-efprpk72	403	13	association	association	NN
cord-012902-efprpk72	403	14	between	between	IN
cord-012902-efprpk72	403	15	VVBPV	VVBPV	NNP
cord-012902-efprpk72	403	16	of	of	IN
cord-012902-efprpk72	403	17	systolic	systolic	JJ
cord-012902-efprpk72	403	18	BP	BP	NNP
cord-012902-efprpk72	403	19	(	(	-LRB-
cord-012902-efprpk72	403	20	SBP	SBP	NNP
cord-012902-efprpk72	403	21	)	)	-RRB-
cord-012902-efprpk72	403	22	as	as	RB
cord-012902-efprpk72	403	23	well	well	RB
cord-012902-efprpk72	403	24	as	as	IN
cord-012902-efprpk72	403	25	diastolic	diastolic	JJ
cord-012902-efprpk72	403	26	BP	BP	NNP
cord-012902-efprpk72	403	27	(	(	-LRB-
cord-012902-efprpk72	403	28	DBP	DBP	NNP
cord-012902-efprpk72	403	29	)	)	-RRB-
cord-012902-efprpk72	403	30	and	and	CC
cord-012902-efprpk72	403	31	progression	progression	NN
cord-012902-efprpk72	403	32	of	of	IN
cord-012902-efprpk72	403	33	renal	renal	JJ
cord-012902-efprpk72	403	34	allograft	allograft	NN
cord-012902-efprpk72	403	35	function	function	NN
cord-012902-efprpk72	403	36	,	,	,
cord-012902-efprpk72	403	37	which	which	WDT
cord-012902-efprpk72	403	38	was	be	VBD
cord-012902-efprpk72	403	39	defined	define	VBN
cord-012902-efprpk72	403	40	by	by	IN
cord-012902-efprpk72	403	41	a	a	DT
cord-012902-efprpk72	403	42	decrease	decrease	NN
cord-012902-efprpk72	403	43	in	in	IN
cord-012902-efprpk72	403	44	estimated	estimate	VBN
cord-012902-efprpk72	403	45	glomerular	glomerular	JJ
cord-012902-efprpk72	403	46	filtration	filtration	NN
cord-012902-efprpk72	403	47	rate	rate	NN
cord-012902-efprpk72	403	48	(	(	-LRB-
cord-012902-efprpk72	404	1	eGFR	eGFR	NNP
cord-012902-efprpk72	404	2	)	)	-RRB-
cord-012902-efprpk72	404	3	after	after	IN
cord-012902-efprpk72	404	4	the	the	DT
cord-012902-efprpk72	404	5	established	establish	VBN
cord-012902-efprpk72	404	6	baseline	baseline	NN
cord-012902-efprpk72	404	7	eGFR	egfr	NN
cord-012902-efprpk72	404	8	at	at	IN
cord-012902-efprpk72	404	9	12-week	12-week	JJ
cord-012902-efprpk72	404	10	post	post	NN
cord-012902-efprpk72	404	11	-	-	JJ
cord-012902-efprpk72	404	12	KT	kt	NN
cord-012902-efprpk72	404	13	.	.	.
cord-012902-efprpk72	405	1	Results	result	NNS
cord-012902-efprpk72	405	2	:	:	:
cord-012902-efprpk72	406	1	Of	of	IN
cord-012902-efprpk72	406	2	102	102	CD
cord-012902-efprpk72	406	3	renal	renal	JJ
cord-012902-efprpk72	406	4	transplant	transplant	NN
cord-012902-efprpk72	406	5	recipients	recipient	NNS
cord-012902-efprpk72	406	6	(	(	-LRB-
cord-012902-efprpk72	406	7	RTR	RTR	NNP
cord-012902-efprpk72	406	8	)	)	-RRB-
cord-012902-efprpk72	406	9	for	for	IN
cord-012902-efprpk72	406	10	a	a	DT
cord-012902-efprpk72	406	11	single	single	JJ
cord-012902-efprpk72	406	12	KT	KT	NNP
cord-012902-efprpk72	406	13	centre	centre	NN
cord-012902-efprpk72	406	14	,	,	,
cord-012902-efprpk72	406	15	mean	mean	JJ
cord-012902-efprpk72	406	16	age±SD	age±SD	NNP
cord-012902-efprpk72	406	17	was	be	VBD
cord-012902-efprpk72	406	18	54.16	54.16	CD
cord-012902-efprpk72	406	19	±	±	CD
cord-012902-efprpk72	406	20	11.73	11.73	CD
cord-012902-efprpk72	406	21	years	year	NNS
cord-012902-efprpk72	406	22	and	and	CC
cord-012902-efprpk72	406	23	63	63	CD
cord-012902-efprpk72	406	24	patients	patient	NNS
cord-012902-efprpk72	406	25	(	(	-LRB-
cord-012902-efprpk72	406	26	62	62	CD
cord-012902-efprpk72	406	27	%	%	NN
cord-012902-efprpk72	406	28	)	)	-RRB-
cord-012902-efprpk72	406	29	was	be	VBD
cord-012902-efprpk72	406	30	female	female	JJ
cord-012902-efprpk72	406	31	.	.	.
cord-012902-efprpk72	407	1	Sixty	sixty	CD
cord-012902-efprpk72	407	2	-	-	HYPH
cord-012902-efprpk72	407	3	three	three	CD
cord-012902-efprpk72	407	4	patients	patient	NNS
cord-012902-efprpk72	407	5	had	have	VBD
cord-012902-efprpk72	407	6	decreased	decrease	VBN
cord-012902-efprpk72	407	7	eGFR	egfr	NN
cord-012902-efprpk72	407	8	after	after	IN
cord-012902-efprpk72	407	9	12-week	12-week	JJ
cord-012902-efprpk72	407	10	post	post	NN
cord-012902-efprpk72	407	11	-	-	JJ
cord-012902-efprpk72	407	12	KT	kt	NN
cord-012902-efprpk72	407	13	with	with	IN
cord-012902-efprpk72	407	14	an	an	DT
cord-012902-efprpk72	407	15	incidence	incidence	NN
cord-012902-efprpk72	407	16	rate	rate	NN
cord-012902-efprpk72	407	17	of	of	IN
cord-012902-efprpk72	407	18	0.017	0.017	CD
cord-012902-efprpk72	407	19	person	person	NN
cord-012902-efprpk72	407	20	-	-	HYPH
cord-012902-efprpk72	407	21	weeks	week	NNS
cord-012902-efprpk72	407	22	and	and	CC
cord-012902-efprpk72	407	23	median	median	JJ
cord-012902-efprpk72	407	24	time	time	NN
cord-012902-efprpk72	407	25	to	to	IN
cord-012902-efprpk72	407	26	event	event	NN
cord-012902-efprpk72	407	27	was	be	VBD
cord-012902-efprpk72	407	28	36	36	CD
cord-012902-efprpk72	407	29	weeks	week	NNS
cord-012902-efprpk72	407	30	.	.	.
cord-012902-efprpk72	408	1	After	after	IN
cord-012902-efprpk72	408	2	adjusted	adjust	VBN
cord-012902-efprpk72	408	3	for	for	IN
cord-012902-efprpk72	408	4	induction	induction	NN
cord-012902-efprpk72	408	5	immunosuppressive	immunosuppressive	JJ
cord-012902-efprpk72	408	6	medications	medication	NNS
cord-012902-efprpk72	408	7	,	,	,
cord-012902-efprpk72	408	8	pretransplant	pretransplant	JJ
cord-012902-efprpk72	408	9	weight	weight	NN
cord-012902-efprpk72	408	10	,	,	,
cord-012902-efprpk72	408	11	posttransplant	posttransplant	NN
cord-012902-efprpk72	408	12	eGFR	egfr	NN
cord-012902-efprpk72	408	13	at	at	IN
cord-012902-efprpk72	408	14	4	4	CD
cord-012902-efprpk72	408	15	and	and	CC
cord-012902-efprpk72	408	16	12	12	CD
cord-012902-efprpk72	408	17	weeks	week	NNS
cord-012902-efprpk72	408	18	,	,	,
cord-012902-efprpk72	408	19	every	every	DT
cord-012902-efprpk72	408	20	1-SD	1-sd	CD
cord-012902-efprpk72	408	21	,	,	,
cord-012902-efprpk72	408	22	1	1	CD
cord-012902-efprpk72	408	23	%	%	NN
cord-012902-efprpk72	408	24	CV	cv	NN
cord-012902-efprpk72	408	25	,	,	,
cord-012902-efprpk72	408	26	and	and	CC
cord-012902-efprpk72	408	27	1-ASV	1-asv	CD
cord-012902-efprpk72	408	28	increase	increase	NN
cord-012902-efprpk72	408	29	in	in	IN
cord-012902-efprpk72	408	30	SBP	SBP	NNP
cord-012902-efprpk72	408	31	was	be	VBD
cord-012902-efprpk72	408	32	significantly	significantly	RB
cord-012902-efprpk72	408	33	associated	associate	VBN
cord-012902-efprpk72	408	34	with	with	IN
cord-012902-efprpk72	408	35	5.54	5.54	CD
cord-012902-efprpk72	408	36	%	%	NN
cord-012902-efprpk72	408	37	,	,	,
cord-012902-efprpk72	408	38	7.81	7.81	CD
cord-012902-efprpk72	408	39	%	%	NN
cord-012902-efprpk72	408	40	,	,	,
cord-012902-efprpk72	408	41	and	and	CC
cord-012902-efprpk72	408	42	3.53	3.53	CD
cord-012902-efprpk72	408	43	%	%	NN
cord-012902-efprpk72	408	44	increase	increase	NN
cord-012902-efprpk72	408	45	in	in	IN
cord-012902-efprpk72	408	46	risk	risk	NN
cord-012902-efprpk72	408	47	of	of	IN
cord-012902-efprpk72	408	48	worsening	worsen	VBG
cord-012902-efprpk72	408	49	renal	renal	JJ
cord-012902-efprpk72	408	50	allograft	allograft	NN
cord-012902-efprpk72	408	51	function	function	NN
cord-012902-efprpk72	408	52	,	,	,
cord-012902-efprpk72	408	53	respectively	respectively	RB
cord-012902-efprpk72	408	54	.	.	.
cord-012902-efprpk72	409	1	The	the	DT
cord-012902-efprpk72	409	2	association	association	NN
cord-012902-efprpk72	409	3	between	between	IN
cord-012902-efprpk72	409	4	all	all	DT
cord-012902-efprpk72	409	5	3	3	CD
cord-012902-efprpk72	409	6	methods	method	NNS
cord-012902-efprpk72	409	7	of	of	IN
cord-012902-efprpk72	409	8	VVBPV	vvbpv	NN
cord-012902-efprpk72	409	9	for	for	IN
cord-012902-efprpk72	409	10	DBP	dbp	NN
cord-012902-efprpk72	409	11	and	and	CC
cord-012902-efprpk72	409	12	worsening	worsen	VBG
cord-012902-efprpk72	409	13	renal	renal	JJ
cord-012902-efprpk72	409	14	allograft	allograft	NN
cord-012902-efprpk72	409	15	function	function	NN
cord-012902-efprpk72	409	16	were	be	VBD
cord-012902-efprpk72	409	17	the	the	DT
cord-012902-efprpk72	409	18	same	same	JJ
cord-012902-efprpk72	409	19	direction	direction	NN
cord-012902-efprpk72	409	20	as	as	IN
cord-012902-efprpk72	409	21	SBP	SBP	NNP
cord-012902-efprpk72	409	22	,	,	,
cord-012902-efprpk72	409	23	but	but	CC
cord-012902-efprpk72	409	24	all	all	DT
cord-012902-efprpk72	409	25	were	be	VBD
cord-012902-efprpk72	409	26	not	not	RB
cord-012902-efprpk72	409	27	significant	significant	JJ
cord-012902-efprpk72	409	28	(	(	-LRB-
cord-012902-efprpk72	409	29	Table	table	NN
cord-012902-efprpk72	409	30	1	1	CD
cord-012902-efprpk72	409	31	)	)	-RRB-
cord-012902-efprpk72	409	32	.	.	.
cord-012902-efprpk72	410	1	Conclusions	conclusion	NNS
cord-012902-efprpk72	410	2	:	:	:
cord-012902-efprpk72	410	3	VVBPV	VVBPV	NNP
cord-012902-efprpk72	410	4	for	for	IN
cord-012902-efprpk72	410	5	SBP	SBP	NNP
cord-012902-efprpk72	410	6	,	,	,
cord-012902-efprpk72	410	7	but	but	CC
cord-012902-efprpk72	410	8	not	not	RB
cord-012902-efprpk72	410	9	DBP	DBP	NNP
cord-012902-efprpk72	410	10	,	,	,
cord-012902-efprpk72	410	11	is	be	VBZ
cord-012902-efprpk72	410	12	an	an	DT
cord-012902-efprpk72	410	13	independent	independent	JJ
cord-012902-efprpk72	410	14	predictor	predictor	NN
cord-012902-efprpk72	410	15	of	of	IN
cord-012902-efprpk72	410	16	worsening	worsen	VBG
cord-012902-efprpk72	410	17	renal	renal	JJ
cord-012902-efprpk72	410	18	allograft	allograft	NN
cord-012902-efprpk72	410	19	function	function	NN
cord-012902-efprpk72	410	20	.	.	.
cord-012902-efprpk72	411	1	Disclosures	disclosure	NNS
cord-012902-efprpk72	411	2	:	:	:
cord-012902-efprpk72	411	3	None	none	NN
cord-012902-efprpk72	411	4	.	.	.
cord-012902-efprpk72	412	1	Table	table	NN
cord-012902-efprpk72	412	2	1	1	CD
cord-012902-efprpk72	412	3	Association	Association	NNP
cord-012902-efprpk72	412	4	between	between	IN
cord-012902-efprpk72	412	5	visit	visit	NN
cord-012902-efprpk72	412	6	-	-	HYPH
cord-012902-efprpk72	412	7	to	to	IN
cord-012902-efprpk72	412	8	-	-	HYPH
cord-012902-efprpk72	412	9	visit	visit	VB
cord-012902-efprpk72	412	10	blood	blood	NN
cord-012902-efprpk72	412	11	pressure	pressure	NN
cord-012902-efprpk72	412	12	variability	variability	NN
cord-012902-efprpk72	412	13	(	(	-LRB-
cord-012902-efprpk72	412	14	VVBPV	VVBPV	NNP
cord-012902-efprpk72	412	15	)	)	-RRB-
cord-012902-efprpk72	412	16	and	and	CC
cord-012902-efprpk72	412	17	a	a	DT
cord-012902-efprpk72	412	18	decrease	decrease	NN
cord-012902-efprpk72	412	19	in	in	IN
cord-012902-efprpk72	412	20	estimated	estimate	VBN
cord-012902-efprpk72	412	21	glomerular	glomerular	JJ
cord-012902-efprpk72	412	22	filtration	filtration	NN
cord-012902-efprpk72	412	23	rate	rate	NN
cord-012902-efprpk72	412	24	after	after	IN
cord-012902-efprpk72	412	25	12-week	12-week	JJ
cord-012902-efprpk72	412	26	post	post	JJ
cord-012902-efprpk72	412	27	-	-	JJ
cord-012902-efprpk72	412	28	kidney	kidney	JJ
cord-012902-efprpk72	412	29	transplantation	transplantation	NN
cord-012902-efprpk72	412	30	.	.	.
cord-012902-efprpk72	413	1	VVBPV	VVBPV	NNP
cord-012902-efprpk72	413	2	were	be	VBD
cord-012902-efprpk72	413	3	assessed	assess	VBN
cord-012902-efprpk72	413	4	by	by	IN
cord-012902-efprpk72	413	5	standard	standard	JJ
cord-012902-efprpk72	413	6	deviation	deviation	NN
cord-012902-efprpk72	413	7	(	(	-LRB-
cord-012902-efprpk72	413	8	SD	sd	NN
cord-012902-efprpk72	413	9	)	)	-RRB-
cord-012902-efprpk72	413	10	of	of	IN
cord-012902-efprpk72	413	11	BP	BP	NNP
cord-012902-efprpk72	413	12	,	,	,
cord-012902-efprpk72	413	13	coefficient	coefficient	NN
cord-012902-efprpk72	413	14	of	of	IN
cord-012902-efprpk72	413	15	variation	variation	NN
cord-012902-efprpk72	413	16	(	(	-LRB-
cord-012902-efprpk72	413	17	CV	CV	NNP
cord-012902-efprpk72	413	18	)	)	-RRB-
cord-012902-efprpk72	413	19	,	,	,
cord-012902-efprpk72	413	20	and	and	CC
cord-012902-efprpk72	413	21	average	average	JJ
cord-012902-efprpk72	413	22	successive	successive	JJ
cord-012902-efprpk72	413	23	variability	variability	NN
cord-012902-efprpk72	413	24	(	(	-LRB-
cord-012902-efprpk72	413	25	ASV	ASV	NNP
cord-012902-efprpk72	413	26	)	)	-RRB-
cord-012902-efprpk72	413	27	.	.	.
cord-012902-efprpk72	414	1	ASV	ASV	NNP
cord-012902-efprpk72	414	2	average	average	JJ
cord-012902-efprpk72	414	3	successive	successive	JJ
cord-012902-efprpk72	414	4	variability	variability	NN
cord-012902-efprpk72	414	5	,	,	,
cord-012902-efprpk72	414	6	CI	CI	NNP
cord-012902-efprpk72	414	7	confident	confident	JJ
cord-012902-efprpk72	414	8	interval	interval	NN
cord-012902-efprpk72	414	9	,	,	,
cord-012902-efprpk72	414	10	CV	cv	NN
cord-012902-efprpk72	414	11	coefficient	coefficient	NN
cord-012902-efprpk72	414	12	of	of	IN
cord-012902-efprpk72	414	13	variation	variation	NN
cord-012902-efprpk72	414	14	,	,	,
cord-012902-efprpk72	414	15	DBP	DBP	NNP
cord-012902-efprpk72	414	16	diastolic	diastolic	JJ
cord-012902-efprpk72	414	17	blood	blood	NN
cord-012902-efprpk72	414	18	pressure	pressure	NN
cord-012902-efprpk72	414	19	,	,	,
cord-012902-efprpk72	414	20	HR	hr	NN
cord-012902-efprpk72	414	21	hazard	hazard	NN
cord-012902-efprpk72	414	22	ratio	ratio	NN
cord-012902-efprpk72	414	23	,	,	,
cord-012902-efprpk72	414	24	SBP	SBP	NNP
cord-012902-efprpk72	414	25	systolic	systolic	JJ
cord-012902-efprpk72	414	26	blood	blood	NN
cord-012902-efprpk72	414	27	pressure	pressure	NN
cord-012902-efprpk72	414	28	,	,	,
cord-012902-efprpk72	414	29	SD	sd	NN
cord-012902-efprpk72	414	30	standard	standard	JJ
cord-012902-efprpk72	414	31	deviation	deviation	NN
cord-012902-efprpk72	414	32	,	,	,
cord-012902-efprpk72	414	33	VVBPV	VVBPV	NNP
cord-012902-efprpk72	414	34	visit	visit	NN
cord-012902-efprpk72	414	35	-	-	HYPH
cord-012902-efprpk72	414	36	to	to	IN
cord-012902-efprpk72	414	37	-	-	HYPH
cord-012902-efprpk72	414	38	visit	visit	VB
cord-012902-efprpk72	414	39	blood	blood	NN
cord-012902-efprpk72	414	40	pressure	pressure	NN
cord-012902-efprpk72	414	41	variability	variability	NN
cord-012902-efprpk72	414	42	.	.	.
cord-012902-efprpk72	415	1	Michaela	Michaela	NNP
cord-012902-efprpk72	415	2	Nuttall	Nuttall	NNP
cord-012902-efprpk72	415	3	1	1	CD
cord-012902-efprpk72	416	1	*	*	NFP
cord-012902-efprpk72	416	2	,	,	,
cord-012902-efprpk72	416	3	Mark	Mark	NNP
cord-012902-efprpk72	416	4	Cobain	Cobain	NNP
cord-012902-efprpk72	416	5	1	1	CD
cord-012902-efprpk72	416	6	Introduction	introduction	NN
cord-012902-efprpk72	416	7	:	:	:
cord-012902-efprpk72	417	1	Nurse	nurse	NN
cord-012902-efprpk72	417	2	and	and	CC
cord-012902-efprpk72	417	3	psychologist	psychologist	NN
cord-012902-efprpk72	417	4	led	lead	VBD
cord-012902-efprpk72	417	5	pilot	pilot	NN
cord-012902-efprpk72	417	6	for	for	IN
cord-012902-efprpk72	417	7	shared	share	VBN
cord-012902-efprpk72	417	8	decision	decision	NN
cord-012902-efprpk72	417	9	-	-	HYPH
cord-012902-efprpk72	417	10	making	make	VBG
cord-012902-efprpk72	417	11	tool	tool	NN
cord-012902-efprpk72	417	12	for	for	IN
cord-012902-efprpk72	417	13	nurses	nurse	NNS
cord-012902-efprpk72	417	14	and	and	CC
cord-012902-efprpk72	417	15	pharmacists	pharmacist	NNS
cord-012902-efprpk72	417	16	with	with	IN
cord-012902-efprpk72	417	17	diagnosed	diagnosed	JJ
cord-012902-efprpk72	417	18	hypertensive	hypertensive	JJ
cord-012902-efprpk72	417	19	patients	patient	NNS
cord-012902-efprpk72	417	20	in	in	IN
cord-012902-efprpk72	417	21	the	the	DT
cord-012902-efprpk72	417	22	UK	UK	NNP
cord-012902-efprpk72	417	23	and	and	CC
cord-012902-efprpk72	417	24	Ireland	Ireland	NNP
cord-012902-efprpk72	417	25	.	.	.
cord-012902-efprpk72	418	1	Featuring	feature	VBG
cord-012902-efprpk72	418	2	the	the	DT
cord-012902-efprpk72	418	3	motivating	motivate	VBG
cord-012902-efprpk72	418	4	CVD	CVD	NNP
cord-012902-efprpk72	418	5	risk	risk	NN
cord-012902-efprpk72	418	6	concept	concept	NN
cord-012902-efprpk72	418	7	'	'	``
cord-012902-efprpk72	418	8	Heart	Heart	NNP
cord-012902-efprpk72	418	9	Age	Age	NNP
cord-012902-efprpk72	418	10	'	'	''
cord-012902-efprpk72	418	11	,	,	,
cord-012902-efprpk72	418	12	patient	patient	JJ
cord-012902-efprpk72	418	13	perceptions	perception	NNS
cord-012902-efprpk72	418	14	of	of	IN
cord-012902-efprpk72	418	15	CVD	CVD	NNP
cord-012902-efprpk72	418	16	risk	risk	NN
cord-012902-efprpk72	418	17	and	and	CC
cord-012902-efprpk72	418	18	benefits	benefit	NNS
cord-012902-efprpk72	418	19	of	of	IN
cord-012902-efprpk72	418	20	different	different	JJ
cord-012902-efprpk72	418	21	intervention	intervention	NN
cord-012902-efprpk72	418	22	strategies	strategy	NNS
cord-012902-efprpk72	418	23	.	.	.
cord-012902-efprpk72	419	1	Patients	patient	NNS
cord-012902-efprpk72	419	2	and	and	CC
cord-012902-efprpk72	419	3	clinicians	clinician	NNS
cord-012902-efprpk72	419	4	can	can	MD
cord-012902-efprpk72	419	5	explore	explore	VB
cord-012902-efprpk72	419	6	different	different	JJ
cord-012902-efprpk72	419	7	options	option	NNS
cord-012902-efprpk72	419	8	for	for	IN
cord-012902-efprpk72	419	9	management	management	NN
cord-012902-efprpk72	419	10	framed	frame	VBN
cord-012902-efprpk72	419	11	,	,	,
cord-012902-efprpk72	419	12	physical	physical	JJ
cord-012902-efprpk72	419	13	activity	activity	NN
cord-012902-efprpk72	419	14	and	and	CC
cord-012902-efprpk72	419	15	medication	medication	NN
cord-012902-efprpk72	419	16	,	,	,
cord-012902-efprpk72	419	17	as	as	IN
cord-012902-efprpk72	419	18	a	a	DT
cord-012902-efprpk72	419	19	way	way	NN
cord-012902-efprpk72	419	20	of	of	IN
cord-012902-efprpk72	419	21	taking	take	VBG
cord-012902-efprpk72	419	22	'	'	''
cord-012902-efprpk72	419	23	years	year	NNS
cord-012902-efprpk72	419	24	off	off	RB
cord-012902-efprpk72	419	25	'	'	''
cord-012902-efprpk72	419	26	their	-PRON-	PRP$
cord-012902-efprpk72	419	27	Heart	Heart	NNP
cord-012902-efprpk72	419	28	Age	Age	NNP
cord-012902-efprpk72	419	29	through	through	IN
cord-012902-efprpk72	419	30	blood	blood	NN
cord-012902-efprpk72	419	31	pressure	pressure	NN
cord-012902-efprpk72	419	32	control	control	NN
cord-012902-efprpk72	419	33	.	.	.
cord-012902-efprpk72	420	1	Heart	Heart	NNP
cord-012902-efprpk72	420	2	Age	Age	NNP
cord-012902-efprpk72	420	3	has	have	VBZ
cord-012902-efprpk72	420	4	been	be	VBN
cord-012902-efprpk72	420	5	shown	show	VBN
cord-012902-efprpk72	420	6	to	to	TO
cord-012902-efprpk72	420	7	be	be	VB
cord-012902-efprpk72	420	8	effective	effective	JJ
cord-012902-efprpk72	420	9	in	in	IN
cord-012902-efprpk72	420	10	motivating	motivate	VBG
cord-012902-efprpk72	420	11	risk	risk	NN
cord-012902-efprpk72	420	12	factor	factor	NN
cord-012902-efprpk72	420	13	reduction	reduction	NN
cord-012902-efprpk72	420	14	[	[	-LRB-
cord-012902-efprpk72	420	15	1	1	CD
cord-012902-efprpk72	420	16	]	]	-RRB-
cord-012902-efprpk72	420	17	and	and	CC
cord-012902-efprpk72	420	18	align	align	VB
cord-012902-efprpk72	420	19	perceived	perceive	VBN
cord-012902-efprpk72	420	20	and	and	CC
cord-012902-efprpk72	420	21	measured	measure	VBN
cord-012902-efprpk72	420	22	risk	risk	NN
cord-012902-efprpk72	420	23	[	[	-LRB-
cord-012902-efprpk72	420	24	2	2	CD
cord-012902-efprpk72	420	25	]	]	-RRB-
cord-012902-efprpk72	420	26	.	.	.
cord-012902-efprpk72	421	1	Methods	method	NNS
cord-012902-efprpk72	421	2	:	:	:
cord-012902-efprpk72	421	3	We	-PRON-	PRP
cord-012902-efprpk72	421	4	will	will	MD
cord-012902-efprpk72	421	5	recruit	recruit	VB
cord-012902-efprpk72	421	6	patients	patient	NNS
cord-012902-efprpk72	421	7	,	,	,
cord-012902-efprpk72	421	8	nurses	nurse	NNS
cord-012902-efprpk72	421	9	and	and	CC
cord-012902-efprpk72	421	10	pharmacists	pharmacist	NNS
cord-012902-efprpk72	421	11	through	through	IN
cord-012902-efprpk72	421	12	established	establish	VBN
cord-012902-efprpk72	421	13	relationships	relationship	NNS
cord-012902-efprpk72	421	14	within	within	IN
cord-012902-efprpk72	421	15	the	the	DT
cord-012902-efprpk72	421	16	third	third	JJ
cord-012902-efprpk72	421	17	sector	sector	NN
cord-012902-efprpk72	421	18	,	,	,
cord-012902-efprpk72	421	19	charities	charity	NNS
cord-012902-efprpk72	421	20	,	,	,
cord-012902-efprpk72	421	21	societies	society	NNS
cord-012902-efprpk72	421	22	and	and	CC
cord-012902-efprpk72	421	23	social	social	JJ
cord-012902-efprpk72	421	24	media	medium	NNS
cord-012902-efprpk72	421	25	.	.	.
cord-012902-efprpk72	422	1	Using	use	VBG
cord-012902-efprpk72	422	2	focus	focus	NN
cord-012902-efprpk72	422	3	groups	group	NNS
cord-012902-efprpk72	422	4	and	and	CC
cord-012902-efprpk72	422	5	surveys	survey	NNS
cord-012902-efprpk72	422	6	,	,	,
cord-012902-efprpk72	422	7	we	-PRON-	PRP
cord-012902-efprpk72	422	8	will	will	MD
cord-012902-efprpk72	422	9	gain	gain	VB
cord-012902-efprpk72	422	10	insight	insight	NN
cord-012902-efprpk72	422	11	into	into	IN
cord-012902-efprpk72	422	12	hypertensive	hypertensive	JJ
cord-012902-efprpk72	422	13	patient	patient	JJ
cord-012902-efprpk72	422	14	preferences	preference	NNS
cord-012902-efprpk72	422	15	for	for	IN
cord-012902-efprpk72	422	16	CVD	CVD	NNP
cord-012902-efprpk72	422	17	risk	risk	NN
cord-012902-efprpk72	422	18	framing	framing	NN
cord-012902-efprpk72	422	19	,	,	,
cord-012902-efprpk72	422	20	quantification	quantification	NN
cord-012902-efprpk72	422	21	of	of	IN
cord-012902-efprpk72	422	22	intervention	intervention	NN
cord-012902-efprpk72	422	23	benefits	benefit	NNS
cord-012902-efprpk72	422	24	(	(	-LRB-
cord-012902-efprpk72	422	25	and	and	CC
cord-012902-efprpk72	422	26	side	side	NN
cord-012902-efprpk72	422	27	effects	effect	NNS
cord-012902-efprpk72	422	28	)	)	-RRB-
cord-012902-efprpk72	422	29	and	and	CC
cord-012902-efprpk72	422	30	processes	process	NNS
cord-012902-efprpk72	422	31	to	to	TO
cord-012902-efprpk72	422	32	facilitate	facilitate	VB
cord-012902-efprpk72	422	33	shared	share	VBN
cord-012902-efprpk72	422	34	decision	decision	NN
cord-012902-efprpk72	422	35	making	making	NN
cord-012902-efprpk72	422	36	.	.	.
cord-012902-efprpk72	423	1	Using	use	VBG
cord-012902-efprpk72	423	2	this	this	DT
cord-012902-efprpk72	423	3	knowledge	knowledge	NN
cord-012902-efprpk72	423	4	,	,	,
cord-012902-efprpk72	423	5	we	-PRON-	PRP
cord-012902-efprpk72	423	6	will	will	MD
cord-012902-efprpk72	423	7	co	co	VB
cord-012902-efprpk72	423	8	-	-	VB
cord-012902-efprpk72	423	9	design	design	VB
cord-012902-efprpk72	423	10	and	and	CC
cord-012902-efprpk72	423	11	deliver	deliver	VB
cord-012902-efprpk72	423	12	a	a	DT
cord-012902-efprpk72	423	13	training	training	NN
cord-012902-efprpk72	423	14	programme	programme	NN
cord-012902-efprpk72	423	15	.	.	.
cord-012902-efprpk72	424	1	Novel	novel	JJ
cord-012902-efprpk72	424	2	adaptations	adaptation	NNS
cord-012902-efprpk72	424	3	of	of	IN
cord-012902-efprpk72	424	4	the	the	DT
cord-012902-efprpk72	424	5	Heart	Heart	NNP
cord-012902-efprpk72	424	6	Age	Age	NNP
cord-012902-efprpk72	424	7	tool	tool	NN
cord-012902-efprpk72	424	8	will	will	MD
cord-012902-efprpk72	424	9	be	be	VB
cord-012902-efprpk72	424	10	created	create	VBN
cord-012902-efprpk72	424	11	to	to	TO
cord-012902-efprpk72	424	12	provide	provide	VB
cord-012902-efprpk72	424	13	(	(	-LRB-
cord-012902-efprpk72	424	14	years	year	NNS
cord-012902-efprpk72	424	15	off	off	RB
cord-012902-efprpk72	424	16	)	)	-RRB-
cord-012902-efprpk72	424	17	benefits	benefit	NNS
cord-012902-efprpk72	424	18	for	for	IN
cord-012902-efprpk72	424	19	different	different	JJ
cord-012902-efprpk72	424	20	aspects	aspect	NNS
cord-012902-efprpk72	424	21	of	of	IN
cord-012902-efprpk72	424	22	blood	blood	NN
cord-012902-efprpk72	424	23	pressure	pressure	NN
cord-012902-efprpk72	424	24	lowering	lower	VBG
cord-012902-efprpk72	424	25	,	,	,
cord-012902-efprpk72	424	26	with	with	IN
cord-012902-efprpk72	424	27	a	a	DT
cord-012902-efprpk72	424	28	focus	focus	NN
cord-012902-efprpk72	424	29	on	on	IN
cord-012902-efprpk72	424	30	the	the	DT
cord-012902-efprpk72	424	31	independent	independent	JJ
cord-012902-efprpk72	424	32	and	and	CC
cord-012902-efprpk72	424	33	joint	joint	JJ
cord-012902-efprpk72	424	34	benefits	benefit	NNS
cord-012902-efprpk72	424	35	of	of	IN
cord-012902-efprpk72	424	36	medication	medication	NN
cord-012902-efprpk72	424	37	management	management	NN
cord-012902-efprpk72	424	38	and	and	CC
cord-012902-efprpk72	424	39	lifestyle	lifestyle	NN
cord-012902-efprpk72	424	40	.	.	.
cord-012902-efprpk72	425	1	Clinicians	clinician	NNS
cord-012902-efprpk72	425	2	using	use	VBG
cord-012902-efprpk72	425	3	their	-PRON-	PRP$
cord-012902-efprpk72	425	4	skills	skill	NNS
cord-012902-efprpk72	425	5	and	and	CC
cord-012902-efprpk72	425	6	knowledge	knowledge	NN
cord-012902-efprpk72	425	7	and	and	CC
cord-012902-efprpk72	425	8	the	the	DT
cord-012902-efprpk72	425	9	modified	modify	VBN
cord-012902-efprpk72	425	10	Heart	Heart	NNP
cord-012902-efprpk72	425	11	Age	Age	NNP
cord-012902-efprpk72	425	12	in	in	IN
cord-012902-efprpk72	425	13	the	the	DT
cord-012902-efprpk72	425	14	clinical	clinical	JJ
cord-012902-efprpk72	425	15	setting	setting	NN
cord-012902-efprpk72	425	16	to	to	TO
cord-012902-efprpk72	425	17	arrive	arrive	VB
cord-012902-efprpk72	425	18	at	at	IN
cord-012902-efprpk72	425	19	joint	joint	JJ
cord-012902-efprpk72	425	20	decisions	decision	NNS
cord-012902-efprpk72	425	21	on	on	IN
cord-012902-efprpk72	425	22	blood	blood	NN
cord-012902-efprpk72	425	23	pressure	pressure	NN
cord-012902-efprpk72	425	24	control	control	NN
cord-012902-efprpk72	425	25	with	with	IN
cord-012902-efprpk72	425	26	patients	patient	NNS
cord-012902-efprpk72	425	27	.	.	.
cord-012902-efprpk72	426	1	Results	result	NNS
cord-012902-efprpk72	426	2	:	:	:
cord-012902-efprpk72	427	1	By	by	IN
cord-012902-efprpk72	427	2	May	May	NNP
cord-012902-efprpk72	427	3	2020	2020	CD
cord-012902-efprpk72	427	4	we	-PRON-	PRP
cord-012902-efprpk72	427	5	will	will	MD
cord-012902-efprpk72	427	6	have	have	VB
cord-012902-efprpk72	427	7	results	result	NNS
cord-012902-efprpk72	427	8	from	from	IN
cord-012902-efprpk72	427	9	the	the	DT
cord-012902-efprpk72	427	10	patient	patient	JJ
cord-012902-efprpk72	427	11	insight	insight	NN
cord-012902-efprpk72	427	12	and	and	CC
cord-012902-efprpk72	427	13	initial	initial	JJ
cord-012902-efprpk72	427	14	findings	finding	NNS
cord-012902-efprpk72	427	15	from	from	IN
cord-012902-efprpk72	427	16	nurses	nurse	NNS
cord-012902-efprpk72	427	17	and	and	CC
cord-012902-efprpk72	427	18	pharmacists	pharmacist	NNS
cord-012902-efprpk72	427	19	.	.	.
cord-012902-efprpk72	428	1	These	these	DT
cord-012902-efprpk72	428	2	will	will	MD
cord-012902-efprpk72	428	3	be	be	VB
cord-012902-efprpk72	428	4	presented	present	VBN
cord-012902-efprpk72	428	5	with	with	IN
cord-012902-efprpk72	428	6	the	the	DT
cord-012902-efprpk72	428	7	full	full	JJ
cord-012902-efprpk72	428	8	pilot	pilot	NN
cord-012902-efprpk72	428	9	plan	plan	NN
cord-012902-efprpk72	428	10	.	.	.
cord-012902-efprpk72	429	1	Conclusions	conclusion	NNS
cord-012902-efprpk72	429	2	:	:	:
cord-012902-efprpk72	430	1	We	-PRON-	PRP
cord-012902-efprpk72	430	2	believe	believe	VBP
cord-012902-efprpk72	430	3	that	that	IN
cord-012902-efprpk72	430	4	shared	share	VBN
cord-012902-efprpk72	430	5	decision	decision	NN
cord-012902-efprpk72	430	6	making	making	NN
cord-012902-efprpk72	430	7	can	can	MD
cord-012902-efprpk72	430	8	only	only	RB
cord-012902-efprpk72	430	9	be	be	VB
cord-012902-efprpk72	430	10	achieved	achieve	VBN
cord-012902-efprpk72	430	11	if	if	IN
cord-012902-efprpk72	430	12	patients	patient	NNS
cord-012902-efprpk72	430	13	understand	understand	VBP
cord-012902-efprpk72	430	14	the	the	DT
cord-012902-efprpk72	430	15	benefit	benefit	NN
cord-012902-efprpk72	430	16	of	of	IN
cord-012902-efprpk72	430	17	personal	personal	JJ
cord-012902-efprpk72	430	18	cardiovascular	cardiovascular	JJ
cord-012902-efprpk72	430	19	risk	risk	NN
cord-012902-efprpk72	430	20	and	and	CC
cord-012902-efprpk72	430	21	risk	risk	NN
cord-012902-efprpk72	430	22	reduction	reduction	NN
cord-012902-efprpk72	430	23	in	in	IN
cord-012902-efprpk72	430	24	order	order	NN
cord-012902-efprpk72	430	25	to	to	TO
cord-012902-efprpk72	430	26	balance	balance	VB
cord-012902-efprpk72	430	27	against	against	IN
cord-012902-efprpk72	430	28	other	other	JJ
cord-012902-efprpk72	430	29	preferences	preference	NNS
cord-012902-efprpk72	430	30	.	.	.
cord-012902-efprpk72	431	1	Disclosures	disclosure	NNS
cord-012902-efprpk72	431	2	:	:	:
cord-012902-efprpk72	432	1	European	European	NNP
cord-012902-efprpk72	432	2	Grant	Grant	NNP
cord-012902-efprpk72	432	3	from	from	IN
cord-012902-efprpk72	432	4	Pfizer	Pfizer	NNP
cord-012902-efprpk72	432	5	.	.	.
cord-012902-efprpk72	433	1	knowledge	knowledge	NN
cord-012902-efprpk72	433	2	and	and	CC
cord-012902-efprpk72	433	3	attitudes	attitude	NNS
cord-012902-efprpk72	433	4	of	of	IN
cord-012902-efprpk72	433	5	the	the	DT
cord-012902-efprpk72	433	6	general	general	JJ
cord-012902-efprpk72	433	7	public	public	NN
cord-012902-efprpk72	433	8	in	in	IN
cord-012902-efprpk72	433	9	Oman	Oman	NNP
cord-012902-efprpk72	433	10	regarding	regard	VBG
cord-012902-efprpk72	433	11	the	the	DT
cord-012902-efprpk72	433	12	dangers	danger	NNS
cord-012902-efprpk72	433	13	of	of	IN
cord-012902-efprpk72	433	14	high	high	JJ
cord-012902-efprpk72	433	15	salt	salt	NN
cord-012902-efprpk72	433	16	intake	intake	NN
cord-012902-efprpk72	433	17	.	.	.
cord-012902-efprpk72	434	1	Methods	method	NNS
cord-012902-efprpk72	434	2	:	:	:
cord-012902-efprpk72	434	3	This	this	DT
cord-012902-efprpk72	434	4	was	be	VBD
cord-012902-efprpk72	434	5	a	a	DT
cord-012902-efprpk72	434	6	cross	cross	JJ
cord-012902-efprpk72	434	7	sectional	sectional	JJ
cord-012902-efprpk72	434	8	questionnaire	questionnaire	NN
cord-012902-efprpk72	434	9	-	-	HYPH
cord-012902-efprpk72	434	10	based	base	VBN
cord-012902-efprpk72	434	11	survey	survey	NN
cord-012902-efprpk72	434	12	,	,	,
cord-012902-efprpk72	434	13	based	base	VBN
cord-012902-efprpk72	434	14	on	on	IN
cord-012902-efprpk72	434	15	the	the	DT
cord-012902-efprpk72	434	16	validated	validate	VBN
cord-012902-efprpk72	434	17	WHO	who	WP
cord-012902-efprpk72	434	18	questionnaire	questionnaire	NN
cord-012902-efprpk72	434	19	[	[	-LRB-
cord-012902-efprpk72	434	20	2	2	CD
cord-012902-efprpk72	434	21	]	]	-RRB-
cord-012902-efprpk72	434	22	.	.	.
cord-012902-efprpk72	435	1	It	-PRON-	PRP
cord-012902-efprpk72	435	2	was	be	VBD
cord-012902-efprpk72	435	3	translated	translate	VBN
cord-012902-efprpk72	435	4	into	into	IN
cord-012902-efprpk72	435	5	Arabic	Arabic	NNP
cord-012902-efprpk72	435	6	by	by	IN
cord-012902-efprpk72	435	7	local	local	JJ
cord-012902-efprpk72	435	8	professionals	professional	NNS
cord-012902-efprpk72	435	9	and	and	CC
cord-012902-efprpk72	435	10	translated	translate	VBD
cord-012902-efprpk72	435	11	back	back	RB
cord-012902-efprpk72	435	12	to	to	IN
cord-012902-efprpk72	435	13	English	English	NNP
cord-012902-efprpk72	435	14	to	to	TO
cord-012902-efprpk72	435	15	check	check	VB
cord-012902-efprpk72	435	16	the	the	DT
cord-012902-efprpk72	435	17	accuracy	accuracy	NN
cord-012902-efprpk72	435	18	of	of	IN
cord-012902-efprpk72	435	19	the	the	DT
cord-012902-efprpk72	435	20	translation	translation	NN
cord-012902-efprpk72	435	21	.	.	.
cord-012902-efprpk72	436	1	All	all	DT
cord-012902-efprpk72	436	2	individuals	individual	NNS
cord-012902-efprpk72	436	3	aged	age	VBN
cord-012902-efprpk72	436	4	18	18	CD
cord-012902-efprpk72	436	5	and	and	CC
cord-012902-efprpk72	436	6	above	above	RB
cord-012902-efprpk72	436	7	were	be	VBD
cord-012902-efprpk72	436	8	invited	invite	VBN
cord-012902-efprpk72	436	9	to	to	TO
cord-012902-efprpk72	436	10	fill	fill	VB
cord-012902-efprpk72	436	11	in	in	RP
cord-012902-efprpk72	436	12	the	the	DT
cord-012902-efprpk72	436	13	questionnaire	questionnaire	NN
cord-012902-efprpk72	436	14	.	.	.
cord-012902-efprpk72	437	1	Results	result	NNS
cord-012902-efprpk72	437	2	:	:	:
cord-012902-efprpk72	438	1	A	a	DT
cord-012902-efprpk72	438	2	total	total	NN
cord-012902-efprpk72	438	3	of	of	IN
cord-012902-efprpk72	438	4	1214	1214	CD
cord-012902-efprpk72	438	5	respondents	respondent	NNS
cord-012902-efprpk72	438	6	(	(	-LRB-
cord-012902-efprpk72	438	7	age	age	NN
cord-012902-efprpk72	438	8	34	34	CD
cord-012902-efprpk72	438	9	+	+	SYM
cord-012902-efprpk72	438	10	10	10	CD
cord-012902-efprpk72	438	11	years	year	NNS
cord-012902-efprpk72	438	12	,	,	,
cord-012902-efprpk72	438	13	65.8	65.8	CD
cord-012902-efprpk72	438	14	%	%	NN
cord-012902-efprpk72	438	15	male	male	NN
cord-012902-efprpk72	438	16	,	,	,
cord-012902-efprpk72	438	17	69.4	69.4	CD
cord-012902-efprpk72	438	18	%	%	NN
cord-012902-efprpk72	438	19	employed,14.2	employed,14.2	CD
cord-012902-efprpk72	438	20	%	%	NN
cord-012902-efprpk72	438	21	hypertensive	hypertensive	JJ
cord-012902-efprpk72	438	22	)	)	-RRB-
cord-012902-efprpk72	438	23	answered	answer	VBD
cord-012902-efprpk72	438	24	the	the	DT
cord-012902-efprpk72	438	25	questionnaire	questionnaire	NN
cord-012902-efprpk72	438	26	.	.	.
cord-012902-efprpk72	439	1	Most	Most	JJS
cord-012902-efprpk72	439	2	felt	feel	VBD
cord-012902-efprpk72	439	3	that	that	IN
cord-012902-efprpk72	439	4	they	-PRON-	PRP
cord-012902-efprpk72	439	5	were	be	VBD
cord-012902-efprpk72	439	6	consuming	consume	VBG
cord-012902-efprpk72	439	7	the	the	DT
cord-012902-efprpk72	439	8	right	right	JJ
cord-012902-efprpk72	439	9	amount	amount	NN
cord-012902-efprpk72	439	10	of	of	IN
cord-012902-efprpk72	439	11	salt	salt	NN
cord-012902-efprpk72	439	12	(	(	-LRB-
cord-012902-efprpk72	439	13	69.4	69.4	CD
cord-012902-efprpk72	439	14	%	%	NN
cord-012902-efprpk72	439	15	)	)	-RRB-
cord-012902-efprpk72	439	16	while	while	IN
cord-012902-efprpk72	439	17	only	only	RB
cord-012902-efprpk72	439	18	6.7	6.7	CD
cord-012902-efprpk72	439	19	%	%	NN
cord-012902-efprpk72	439	20	thought	think	VBD
cord-012902-efprpk72	439	21	that	that	IN
cord-012902-efprpk72	439	22	they	-PRON-	PRP
cord-012902-efprpk72	439	23	were	be	VBD
cord-012902-efprpk72	439	24	consuming	consume	VBG
cord-012902-efprpk72	439	25	more	more	JJR
cord-012902-efprpk72	439	26	than	than	IN
cord-012902-efprpk72	439	27	they	-PRON-	PRP
cord-012902-efprpk72	439	28	should	should	MD
cord-012902-efprpk72	439	29	.	.	.
cord-012902-efprpk72	440	1	Most	Most	JJS
cord-012902-efprpk72	440	2	of	of	IN
cord-012902-efprpk72	440	3	the	the	DT
cord-012902-efprpk72	440	4	respondents	respondent	NNS
cord-012902-efprpk72	440	5	always	always	RB
cord-012902-efprpk72	440	6	add	add	VBP
cord-012902-efprpk72	440	7	salt	salt	NN
cord-012902-efprpk72	440	8	while	while	IN
cord-012902-efprpk72	440	9	cooking	cooking	NN
cord-012902-efprpk72	440	10	(	(	-LRB-
cord-012902-efprpk72	440	11	80	80	CD
cord-012902-efprpk72	440	12	%	%	NN
cord-012902-efprpk72	440	13	)	)	-RRB-
cord-012902-efprpk72	440	14	,	,	,
cord-012902-efprpk72	440	15	and	and	CC
cord-012902-efprpk72	440	16	sometimes	sometimes	RB
cord-012902-efprpk72	440	17	or	or	CC
cord-012902-efprpk72	440	18	always	always	RB
cord-012902-efprpk72	440	19	add	add	VB
cord-012902-efprpk72	440	20	salt	salt	NN
cord-012902-efprpk72	440	21	at	at	IN
cord-012902-efprpk72	440	22	the	the	DT
cord-012902-efprpk72	440	23	table	table	NN
cord-012902-efprpk72	440	24	(	(	-LRB-
cord-012902-efprpk72	440	25	61.4	61.4	CD
cord-012902-efprpk72	440	26	%	%	NN
cord-012902-efprpk72	440	27	)	)	-RRB-
cord-012902-efprpk72	440	28	.	.	.
cord-012902-efprpk72	441	1	Most	Most	JJS
cord-012902-efprpk72	441	2	(	(	-LRB-
cord-012902-efprpk72	441	3	90.7	90.7	CD
cord-012902-efprpk72	441	4	%	%	NN
cord-012902-efprpk72	441	5	)	)	-RRB-
cord-012902-efprpk72	441	6	were	be	VBD
cord-012902-efprpk72	441	7	aware	aware	JJ
cord-012902-efprpk72	441	8	that	that	IN
cord-012902-efprpk72	441	9	excess	excess	JJ
cord-012902-efprpk72	441	10	salt	salt	NN
cord-012902-efprpk72	441	11	can	can	MD
cord-012902-efprpk72	441	12	cause	cause	VB
cord-012902-efprpk72	441	13	diseases	disease	NNS
cord-012902-efprpk72	441	14	such	such	JJ
cord-012902-efprpk72	441	15	as	as	IN
cord-012902-efprpk72	441	16	hypertension	hypertension	NN
cord-012902-efprpk72	441	17	and	and	CC
cord-012902-efprpk72	441	18	that	that	IN
cord-012902-efprpk72	441	19	it	-PRON-	PRP
cord-012902-efprpk72	441	20	is	be	VBZ
cord-012902-efprpk72	441	21	either	either	CC
cord-012902-efprpk72	441	22	somewhat	somewhat	RB
cord-012902-efprpk72	441	23	important	important	JJ
cord-012902-efprpk72	441	24	(	(	-LRB-
cord-012902-efprpk72	441	25	51.2	51.2	CD
cord-012902-efprpk72	441	26	%	%	NN
cord-012902-efprpk72	441	27	)	)	-RRB-
cord-012902-efprpk72	441	28	or	or	CC
cord-012902-efprpk72	441	29	very	very	RB
cord-012902-efprpk72	441	30	important	important	JJ
cord-012902-efprpk72	441	31	(	(	-LRB-
cord-012902-efprpk72	441	32	43.2	43.2	CD
cord-012902-efprpk72	441	33	%	%	NN
cord-012902-efprpk72	441	34	)	)	-RRB-
cord-012902-efprpk72	441	35	to	to	TO
cord-012902-efprpk72	441	36	reduce	reduce	VB
cord-012902-efprpk72	441	37	salt	salt	NN
cord-012902-efprpk72	441	38	in	in	IN
cord-012902-efprpk72	441	39	the	the	DT
cord-012902-efprpk72	441	40	diet	diet	NN
cord-012902-efprpk72	441	41	.	.	.
cord-012902-efprpk72	442	1	However	however	RB
cord-012902-efprpk72	442	2	only	only	RB
cord-012902-efprpk72	442	3	42	42	CD
cord-012902-efprpk72	442	4	%	%	NN
cord-012902-efprpk72	442	5	said	say	VBD
cord-012902-efprpk72	442	6	that	that	IN
cord-012902-efprpk72	442	7	they	-PRON-	PRP
cord-012902-efprpk72	442	8	actively	actively	RB
cord-012902-efprpk72	442	9	try	try	VBP
cord-012902-efprpk72	442	10	to	to	TO
cord-012902-efprpk72	442	11	reduce	reduce	VB
cord-012902-efprpk72	442	12	salt	salt	NN
cord-012902-efprpk72	442	13	in	in	IN
cord-012902-efprpk72	442	14	their	-PRON-	PRP$
cord-012902-efprpk72	442	15	diet	diet	NN
cord-012902-efprpk72	442	16	.	.	.
cord-012902-efprpk72	443	1	Only	only	RB
cord-012902-efprpk72	443	2	around	around	IN
cord-012902-efprpk72	443	3	a	a	DT
cord-012902-efprpk72	443	4	quarter	quarter	NN
cord-012902-efprpk72	443	5	check	check	VBP
cord-012902-efprpk72	443	6	the	the	DT
cord-012902-efprpk72	443	7	label	label	NN
cord-012902-efprpk72	443	8	of	of	IN
cord-012902-efprpk72	443	9	the	the	DT
cord-012902-efprpk72	443	10	food	food	NN
cord-012902-efprpk72	443	11	for	for	IN
cord-012902-efprpk72	443	12	salt	salt	NN
cord-012902-efprpk72	443	13	content	content	NN
cord-012902-efprpk72	443	14	before	before	IN
cord-012902-efprpk72	443	15	they	-PRON-	PRP
cord-012902-efprpk72	443	16	buy	buy	VBP
cord-012902-efprpk72	443	17	.	.	.
cord-012902-efprpk72	444	1	Only	only	RB
cord-012902-efprpk72	444	2	54	54	CD
cord-012902-efprpk72	444	3	(	(	-LRB-
cord-012902-efprpk72	444	4	4.4	4.4	CD
cord-012902-efprpk72	444	5	%	%	NN
cord-012902-efprpk72	444	6	)	)	-RRB-
cord-012902-efprpk72	444	7	said	say	VBD
cord-012902-efprpk72	444	8	they	-PRON-	PRP
cord-012902-efprpk72	444	9	knew	know	VBD
cord-012902-efprpk72	444	10	what	what	WP
cord-012902-efprpk72	444	11	the	the	DT
cord-012902-efprpk72	444	12	recommended	recommend	VBN
cord-012902-efprpk72	444	13	limit	limit	NN
cord-012902-efprpk72	444	14	of	of	IN
cord-012902-efprpk72	444	15	salt	salt	NN
cord-012902-efprpk72	444	16	intake	intake	NN
cord-012902-efprpk72	444	17	is	be	VBZ
cord-012902-efprpk72	444	18	,	,	,
cord-012902-efprpk72	444	19	but	but	CC
cord-012902-efprpk72	444	20	only	only	RB
cord-012902-efprpk72	444	21	5	5	CD
cord-012902-efprpk72	444	22	got	get	VBD
cord-012902-efprpk72	444	23	it	-PRON-	PRP
cord-012902-efprpk72	444	24	correct	correct	JJ
cord-012902-efprpk72	444	25	.	.	.
cord-012902-efprpk72	445	1	The	the	DT
cord-012902-efprpk72	445	2	factors	factor	NNS
cord-012902-efprpk72	445	3	that	that	WDT
cord-012902-efprpk72	445	4	determine	determine	VBP
cord-012902-efprpk72	445	5	whether	whether	IN
cord-012902-efprpk72	445	6	or	or	CC
cord-012902-efprpk72	445	7	not	not	RB
cord-012902-efprpk72	445	8	a	a	DT
cord-012902-efprpk72	445	9	person	person	NN
cord-012902-efprpk72	445	10	tries	try	VBZ
cord-012902-efprpk72	445	11	to	to	TO
cord-012902-efprpk72	445	12	reduce	reduce	VB
cord-012902-efprpk72	445	13	salt	salt	NN
cord-012902-efprpk72	445	14	in	in	IN
cord-012902-efprpk72	445	15	diet	diet	NN
cord-012902-efprpk72	445	16	were	be	VBD
cord-012902-efprpk72	445	17	age	age	NN
cord-012902-efprpk72	445	18	,	,	,
cord-012902-efprpk72	445	19	sex	sex	NN
cord-012902-efprpk72	445	20	,	,	,
cord-012902-efprpk72	445	21	educational	educational	JJ
cord-012902-efprpk72	445	22	level	level	NN
cord-012902-efprpk72	445	23	and	and	CC
cord-012902-efprpk72	445	24	occupation	occupation	NN
cord-012902-efprpk72	445	25	(	(	-LRB-
cord-012902-efprpk72	445	26	all	all	DT
cord-012902-efprpk72	445	27	p	p	NN
cord-012902-efprpk72	445	28	<	<	XX
cord-012902-efprpk72	445	29	0.001	0.001	CD
cord-012902-efprpk72	445	30	)	)	-RRB-
cord-012902-efprpk72	445	31	.	.	.
cord-012902-efprpk72	446	1	However	however	RB
cord-012902-efprpk72	446	2	,	,	,
cord-012902-efprpk72	446	3	being	be	VBG
cord-012902-efprpk72	446	4	hypertensive	hypertensive	JJ
cord-012902-efprpk72	446	5	was	be	VBD
cord-012902-efprpk72	446	6	not	not	RB
cord-012902-efprpk72	446	7	a	a	DT
cord-012902-efprpk72	446	8	predictor	predictor	NN
cord-012902-efprpk72	446	9	.	.	.
cord-012902-efprpk72	447	1	Conclusions	conclusion	NNS
cord-012902-efprpk72	447	2	:	:	:
cord-012902-efprpk72	448	1	Although	although	IN
cord-012902-efprpk72	448	2	most	most	JJS
cord-012902-efprpk72	448	3	people	people	NNS
cord-012902-efprpk72	448	4	in	in	IN
cord-012902-efprpk72	448	5	Oman	Oman	NNP
cord-012902-efprpk72	448	6	in	in	IN
cord-012902-efprpk72	448	7	our	-PRON-	PRP$
cord-012902-efprpk72	448	8	sample	sample	NN
cord-012902-efprpk72	448	9	appear	appear	VBP
cord-012902-efprpk72	448	10	to	to	TO
cord-012902-efprpk72	448	11	be	be	VB
cord-012902-efprpk72	448	12	aware	aware	JJ
cord-012902-efprpk72	448	13	of	of	IN
cord-012902-efprpk72	448	14	the	the	DT
cord-012902-efprpk72	448	15	dangers	danger	NNS
cord-012902-efprpk72	448	16	of	of	IN
cord-012902-efprpk72	448	17	high	high	JJ
cord-012902-efprpk72	448	18	salt	salt	NN
cord-012902-efprpk72	448	19	intake	intake	NN
cord-012902-efprpk72	448	20	,	,	,
cord-012902-efprpk72	448	21	only	only	RB
cord-012902-efprpk72	448	22	a	a	DT
cord-012902-efprpk72	448	23	few	few	JJ
cord-012902-efprpk72	448	24	are	be	VBP
cord-012902-efprpk72	448	25	actively	actively	RB
cord-012902-efprpk72	448	26	trying	try	VBG
cord-012902-efprpk72	448	27	to	to	TO
cord-012902-efprpk72	448	28	reduce	reduce	VB
cord-012902-efprpk72	448	29	it	-PRON-	PRP
cord-012902-efprpk72	448	30	.	.	.
cord-012902-efprpk72	449	1	More	More	JJR
cord-012902-efprpk72	449	2	educational	educational	JJ
cord-012902-efprpk72	449	3	activities	activity	NNS
cord-012902-efprpk72	449	4	are	be	VBP
cord-012902-efprpk72	449	5	required	require	VBN
cord-012902-efprpk72	449	6	to	to	TO
cord-012902-efprpk72	449	7	improve	improve	VB
cord-012902-efprpk72	449	8	awareness	awareness	NN
cord-012902-efprpk72	449	9	especially	especially	RB
cord-012902-efprpk72	449	10	among	among	IN
cord-012902-efprpk72	449	11	the	the	DT
cord-012902-efprpk72	449	12	hypertensive	hypertensive	JJ
cord-012902-efprpk72	449	13	patients	patient	NNS
cord-012902-efprpk72	449	14	.	.	.
cord-012902-efprpk72	450	1	Disclosures	disclosure	NNS
cord-012902-efprpk72	450	2	:	:	:
cord-012902-efprpk72	451	1	The	the	DT
cord-012902-efprpk72	451	2	authors	author	NNS
cord-012902-efprpk72	451	3	have	have	VBP
cord-012902-efprpk72	451	4	no	no	DT
cord-012902-efprpk72	451	5	disclosures	disclosure	NNS
cord-012902-efprpk72	451	6	.	.	.
cord-012902-efprpk72	452	1	Introduction	introduction	NN
cord-012902-efprpk72	452	2	:	:	:
cord-012902-efprpk72	453	1	High	high	JJ
cord-012902-efprpk72	453	2	sodium	sodium	NN
cord-012902-efprpk72	453	3	(	(	-LRB-
cord-012902-efprpk72	453	4	Na	Na	NNP
cord-012902-efprpk72	453	5	)	)	-RRB-
cord-012902-efprpk72	453	6	and	and	CC
cord-012902-efprpk72	453	7	inadequate	inadequate	JJ
cord-012902-efprpk72	453	8	potassium	potassium	NN
cord-012902-efprpk72	453	9	(	(	-LRB-
cord-012902-efprpk72	453	10	K	K	NNP
cord-012902-efprpk72	453	11	)	)	-RRB-
cord-012902-efprpk72	453	12	intake	intake	NN
cord-012902-efprpk72	453	13	are	be	VBP
cord-012902-efprpk72	453	14	important	important	JJ
cord-012902-efprpk72	453	15	determinants	determinant	NNS
cord-012902-efprpk72	453	16	of	of	IN
cord-012902-efprpk72	453	17	high	high	JJ
cord-012902-efprpk72	453	18	blood	blood	NN
cord-012902-efprpk72	453	19	pressure	pressure	NN
cord-012902-efprpk72	453	20	(	(	-LRB-
cord-012902-efprpk72	453	21	BP	BP	NNP
cord-012902-efprpk72	453	22	)	)	-RRB-
cord-012902-efprpk72	453	23	and	and	CC
cord-012902-efprpk72	453	24	cardiovascular	cardiovascular	JJ
cord-012902-efprpk72	453	25	diseases	disease	NNS
cord-012902-efprpk72	453	26	(	(	-LRB-
cord-012902-efprpk72	453	27	CVDs	CVDs	NNP
cord-012902-efprpk72	453	28	)	)	-RRB-
cord-012902-efprpk72	453	29	.	.	.
cord-012902-efprpk72	454	1	In	in	IN
cord-012902-efprpk72	454	2	Oman	Oman	NNP
cord-012902-efprpk72	454	3	,	,	,
cord-012902-efprpk72	454	4	CVD	CVD	NNP
cord-012902-efprpk72	454	5	represents	represent	VBZ
cord-012902-efprpk72	454	6	a	a	DT
cord-012902-efprpk72	454	7	common	common	JJ
cord-012902-efprpk72	454	8	cause	cause	NN
cord-012902-efprpk72	454	9	of	of	IN
cord-012902-efprpk72	454	10	population	population	NN
cord-012902-efprpk72	454	11	morbidity	morbidity	NN
cord-012902-efprpk72	454	12	and	and	CC
cord-012902-efprpk72	454	13	mortality	mortality	NN
cord-012902-efprpk72	454	14	,	,	,
cord-012902-efprpk72	454	15	accounting	account	VBG
cord-012902-efprpk72	454	16	for	for	IN
cord-012902-efprpk72	454	17	33.0	33.0	CD
cord-012902-efprpk72	454	18	%	%	NN
cord-012902-efprpk72	454	19	of	of	IN
cord-012902-efprpk72	454	20	all	all	DT
cord-012902-efprpk72	454	21	deaths	death	NNS
cord-012902-efprpk72	454	22	.	.	.
cord-012902-efprpk72	455	1	The	the	DT
cord-012902-efprpk72	455	2	aim	aim	NN
cord-012902-efprpk72	455	3	of	of	IN
cord-012902-efprpk72	455	4	the	the	DT
cord-012902-efprpk72	455	5	present	present	JJ
cord-012902-efprpk72	455	6	survey	survey	NN
cord-012902-efprpk72	455	7	was	be	VBD
cord-012902-efprpk72	455	8	to	to	TO
cord-012902-efprpk72	455	9	establish	establish	VB
cord-012902-efprpk72	455	10	baseline	baseline	JJ
cord-012902-efprpk72	455	11	average	average	JJ
cord-012902-efprpk72	455	12	consumption	consumption	NN
cord-012902-efprpk72	455	13	of	of	IN
cord-012902-efprpk72	455	14	Na	Na	NNP
cord-012902-efprpk72	455	15	and	and	CC
cord-012902-efprpk72	455	16	K	K	NNP
cord-012902-efprpk72	455	17	,	,	,
cord-012902-efprpk72	455	18	and	and	CC
cord-012902-efprpk72	455	19	explore	explore	VB
cord-012902-efprpk72	455	20	knowledge	knowledge	NN
cord-012902-efprpk72	455	21	,	,	,
cord-012902-efprpk72	455	22	attitudes	attitude	NNS
cord-012902-efprpk72	455	23	and	and	CC
cord-012902-efprpk72	455	24	behaviour	behaviour	NN
cord-012902-efprpk72	455	25	(	(	-LRB-
cord-012902-efprpk72	455	26	KAB	KAB	NNP
cord-012902-efprpk72	455	27	)	)	-RRB-
cord-012902-efprpk72	455	28	towards	towards	IN
cord-012902-efprpk72	455	29	the	the	DT
cord-012902-efprpk72	455	30	use	use	NN
cord-012902-efprpk72	455	31	of	of	IN
cord-012902-efprpk72	455	32	salt	salt	NN
cord-012902-efprpk72	455	33	,	,	,
cord-012902-efprpk72	455	34	in	in	IN
cord-012902-efprpk72	455	35	a	a	DT
cord-012902-efprpk72	455	36	nationally	nationally	RB
cord-012902-efprpk72	455	37	representative	representative	JJ
cord-012902-efprpk72	455	38	random	random	JJ
cord-012902-efprpk72	455	39	sample	sample	NN
cord-012902-efprpk72	455	40	of	of	IN
cord-012902-efprpk72	455	41	men	man	NNS
cord-012902-efprpk72	455	42	and	and	CC
cord-012902-efprpk72	455	43	women	woman	NNS
cord-012902-efprpk72	455	44	.	.	.
cord-012902-efprpk72	456	1	Methods	method	NNS
cord-012902-efprpk72	456	2	:	:	:
cord-012902-efprpk72	456	3	The	the	DT
cord-012902-efprpk72	456	4	study	study	NN
cord-012902-efprpk72	456	5	was	be	VBD
cord-012902-efprpk72	456	6	a	a	DT
cord-012902-efprpk72	456	7	national	national	JJ
cord-012902-efprpk72	456	8	cross	cross	JJ
cord-012902-efprpk72	456	9	-	-	JJ
cord-012902-efprpk72	456	10	sectional	sectional	JJ
cord-012902-efprpk72	456	11	population	population	NN
cord-012902-efprpk72	456	12	-	-	HYPH
cord-012902-efprpk72	456	13	based	base	VBN
cord-012902-efprpk72	456	14	survey	survey	NN
cord-012902-efprpk72	456	15	of	of	IN
cord-012902-efprpk72	456	16	proportional	proportional	JJ
cord-012902-efprpk72	456	17	random	random	JJ
cord-012902-efprpk72	456	18	samples	sample	NNS
cord-012902-efprpk72	456	19	,	,	,
cord-012902-efprpk72	456	20	representative	representative	NN
cord-012902-efprpk72	456	21	of	of	IN
cord-012902-efprpk72	456	22	Omani	omani	JJ
cord-012902-efprpk72	456	23	adults	adult	NNS
cord-012902-efprpk72	456	24	(	(	-LRB-
cord-012902-efprpk72	456	25	18	18	CD
cord-012902-efprpk72	456	26	years	year	NNS
cord-012902-efprpk72	456	27	and	and	CC
cord-012902-efprpk72	456	28	older	old	JJR
cord-012902-efprpk72	456	29	)	)	-RRB-
cord-012902-efprpk72	456	30	,	,	,
cord-012902-efprpk72	456	31	obtained	obtain	VBN
cord-012902-efprpk72	456	32	from	from	IN
cord-012902-efprpk72	456	33	all	all	DT
cord-012902-efprpk72	456	34	Governorates	governorate	NNS
cord-012902-efprpk72	456	35	of	of	IN
cord-012902-efprpk72	456	36	Oman	Oman	NNP
cord-012902-efprpk72	456	37	.	.	.
cord-012902-efprpk72	457	1	Of	of	IN
cord-012902-efprpk72	457	2	the	the	DT
cord-012902-efprpk72	457	3	999	999	CD
cord-012902-efprpk72	457	4	who	who	WP
cord-012902-efprpk72	457	5	agreed	agree	VBD
cord-012902-efprpk72	457	6	to	to	TO
cord-012902-efprpk72	457	7	participate	participate	VB
cord-012902-efprpk72	457	8	,	,	,
cord-012902-efprpk72	457	9	after	after	IN
cord-012902-efprpk72	457	10	a	a	DT
cord-012902-efprpk72	457	11	robust	robust	JJ
cord-012902-efprpk72	457	12	protocol	protocol	NN
cord-012902-efprpk72	457	13	to	to	TO
cord-012902-efprpk72	457	14	ascertain	ascertain	VB
cord-012902-efprpk72	457	15	good	good	JJ
cord-012902-efprpk72	457	16	quality	quality	NN
cord-012902-efprpk72	457	17	of	of	IN
cord-012902-efprpk72	457	18	data	datum	NNS
cord-012902-efprpk72	457	19	,	,	,
cord-012902-efprpk72	457	20	five	five	CD
cord-012902-efprpk72	457	21	hundred	hundred	CD
cord-012902-efprpk72	457	22	and	and	CC
cord-012902-efprpk72	457	23	sixty	sixty	CD
cord-012902-efprpk72	457	24	-	-	HYPH
cord-012902-efprpk72	457	25	nine	nine	CD
cord-012902-efprpk72	457	26	(	(	-LRB-
cord-012902-efprpk72	457	27	193	193	CD
cord-012902-efprpk72	457	28	men	man	NNS
cord-012902-efprpk72	457	29	,	,	,
cord-012902-efprpk72	457	30	376	376	CD
cord-012902-efprpk72	457	31	women	woman	NNS
cord-012902-efprpk72	457	32	;	;	:
cord-012902-efprpk72	457	33	response	response	NN
cord-012902-efprpk72	457	34	rate	rate	NN
cord-012902-efprpk72	457	35	57	57	CD
cord-012902-efprpk72	457	36	%	%	NN
cord-012902-efprpk72	457	37	;	;	:
cord-012902-efprpk72	457	38	mean	mean	VB
cord-012902-efprpk72	457	39	age	age	NN
cord-012902-efprpk72	457	40	39.4	39.4	CD
cord-012902-efprpk72	457	41	years	year	NNS
cord-012902-efprpk72	458	1	[	[	-LRB-
cord-012902-efprpk72	458	2	SD	SD	NNP
cord-012902-efprpk72	458	3	13.1	13.1	CD
cord-012902-efprpk72	458	4	]	]	-RRB-
cord-012902-efprpk72	458	5	)	)	-RRB-
cord-012902-efprpk72	458	6	were	be	VBD
cord-012902-efprpk72	458	7	included	include	VBN
cord-012902-efprpk72	458	8	in	in	IN
cord-012902-efprpk72	458	9	the	the	DT
cord-012902-efprpk72	458	10	final	final	JJ
cord-012902-efprpk72	458	11	analysis	analysis	NN
cord-012902-efprpk72	458	12	.	.	.
cord-012902-efprpk72	459	1	The	the	DT
cord-012902-efprpk72	459	2	characteristics	characteristic	NNS
cord-012902-efprpk72	459	3	of	of	IN
cord-012902-efprpk72	459	4	those	those	DT
cord-012902-efprpk72	459	5	excluded	exclude	VBN
cord-012902-efprpk72	459	6	were	be	VBD
cord-012902-efprpk72	459	7	comparable	comparable	JJ
cord-012902-efprpk72	459	8	to	to	IN
cord-012902-efprpk72	459	9	those	those	DT
cord-012902-efprpk72	459	10	included	include	VBN
cord-012902-efprpk72	459	11	.	.	.
cord-012902-efprpk72	460	1	Participants	participant	NNS
cord-012902-efprpk72	460	2	attended	attend	VBD
cord-012902-efprpk72	460	3	a	a	DT
cord-012902-efprpk72	460	4	screening	screening	NN
cord-012902-efprpk72	460	5	including	include	VBG
cord-012902-efprpk72	460	6	demographic	demographic	JJ
cord-012902-efprpk72	460	7	,	,	,
cord-012902-efprpk72	460	8	anthropometric	anthropometric	JJ
cord-012902-efprpk72	460	9	and	and	CC
cord-012902-efprpk72	460	10	physical	physical	JJ
cord-012902-efprpk72	460	11	measurements	measurement	NNS
cord-012902-efprpk72	460	12	by	by	IN
cord-012902-efprpk72	460	13	standardised	standardised	JJ
cord-012902-efprpk72	460	14	methods	method	NNS
cord-012902-efprpk72	460	15	.	.	.
cord-012902-efprpk72	461	1	Dietary	dietary	JJ
cord-012902-efprpk72	461	2	Na	Na	NNP
cord-012902-efprpk72	461	3	(	(	-LRB-
cord-012902-efprpk72	461	4	salt	salt	NN
cord-012902-efprpk72	461	5	)	)	-RRB-
cord-012902-efprpk72	461	6	and	and	CC
cord-012902-efprpk72	461	7	K	K	NNP
cord-012902-efprpk72	461	8	intakes	intake	NNS
cord-012902-efprpk72	461	9	were	be	VBD
cord-012902-efprpk72	461	10	assessed	assess	VBN
cord-012902-efprpk72	461	11	by	by	IN
cord-012902-efprpk72	461	12	24	24	CD
cord-012902-efprpk72	461	13	h	h	NN
cord-012902-efprpk72	461	14	urinary	urinary	JJ
cord-012902-efprpk72	461	15	Na	Na	NNP
cord-012902-efprpk72	461	16	(	(	-LRB-
cord-012902-efprpk72	461	17	UNa	UNa	NNP
cord-012902-efprpk72	461	18	)	)	-RRB-
cord-012902-efprpk72	461	19	and	and	CC
cord-012902-efprpk72	461	20	K	K	NNP
cord-012902-efprpk72	461	21	(	(	-LRB-
cord-012902-efprpk72	461	22	UK	UK	NNP
cord-012902-efprpk72	461	23	)	)	-RRB-
cord-012902-efprpk72	461	24	excretions	excretion	NNS
cord-012902-efprpk72	461	25	.	.	.
cord-012902-efprpk72	462	1	Urinary	urinary	JJ
cord-012902-efprpk72	462	2	creatinine	creatinine	NN
cord-012902-efprpk72	462	3	was	be	VBD
cord-012902-efprpk72	462	4	also	also	RB
cord-012902-efprpk72	462	5	measured	measure	VBN
cord-012902-efprpk72	462	6	.	.	.
cord-012902-efprpk72	463	1	KAB	KAB	NNP
cord-012902-efprpk72	463	2	were	be	VBD
cord-012902-efprpk72	463	3	assessed	assess	VBN
cord-012902-efprpk72	463	4	by	by	IN
cord-012902-efprpk72	463	5	questionnaire	questionnaire	NN
cord-012902-efprpk72	463	6	.	.	.
cord-012902-efprpk72	464	1	Results	result	NNS
cord-012902-efprpk72	464	2	:	:	:
cord-012902-efprpk72	465	1	Mean	mean	JJ
cord-012902-efprpk72	465	2	UNa	UNa	NNS
cord-012902-efprpk72	465	3	was	be	VBD
cord-012902-efprpk72	465	4	144.3	144.3	CD
cord-012902-efprpk72	465	5	(	(	-LRB-
cord-012902-efprpk72	465	6	78.8	78.8	CD
cord-012902-efprpk72	465	7	)	)	-RRB-
cord-012902-efprpk72	465	8	mmoL	mmoL	NNP
cord-012902-efprpk72	465	9	/	/	SYM
cord-012902-efprpk72	465	10	day	day	NN
cord-012902-efprpk72	465	11	,	,	,
cord-012902-efprpk72	465	12	equivalent	equivalent	JJ
cord-012902-efprpk72	465	13	to	to	IN
cord-012902-efprpk72	465	14	9.0	9.0	CD
cord-012902-efprpk72	465	15	g	g	NN
cord-012902-efprpk72	465	16	of	of	IN
cord-012902-efprpk72	465	17	salt	salt	NN
cord-012902-efprpk72	465	18	/	/	SYM
cord-012902-efprpk72	465	19	day	day	NN
cord-012902-efprpk72	465	20	and	and	CC
cord-012902-efprpk72	465	21	potassium	potassium	NN
cord-012902-efprpk72	465	22	excretion	excretion	NN
cord-012902-efprpk72	465	23	52.6	52.6	CD
cord-012902-efprpk72	465	24	(	(	-LRB-
cord-012902-efprpk72	465	25	32.6	32.6	CD
cord-012902-efprpk72	465	26	)	)	-RRB-
cord-012902-efprpk72	465	27	mmoL	mmoL	NNP
cord-012902-efprpk72	465	28	/	/	SYM
cord-012902-efprpk72	465	29	day	day	NN
cord-012902-efprpk72	465	30	,	,	,
cord-012902-efprpk72	465	31	equivalent	equivalent	JJ
cord-012902-efprpk72	465	32	to	to	IN
cord-012902-efprpk72	465	33	2.36	2.36	CD
cord-012902-efprpk72	465	34	g	g	NN
cord-012902-efprpk72	465	35	/	/	SYM
cord-012902-efprpk72	465	36	day	day	NN
cord-012902-efprpk72	465	37	.	.	.
cord-012902-efprpk72	466	1	Men	man	NNS
cord-012902-efprpk72	466	2	ate	eat	VBD
cord-012902-efprpk72	466	3	more	more	JJR
cord-012902-efprpk72	466	4	sodium	sodium	NN
cord-012902-efprpk72	466	5	and	and	CC
cord-012902-efprpk72	466	6	potassium	potassium	NN
cord-012902-efprpk72	466	7	than	than	IN
cord-012902-efprpk72	466	8	women	woman	NNS
cord-012902-efprpk72	466	9	.	.	.
cord-012902-efprpk72	467	1	Only	only	RB
cord-012902-efprpk72	467	2	22	22	CD
cord-012902-efprpk72	467	3	%	%	NN
cord-012902-efprpk72	467	4	of	of	IN
cord-012902-efprpk72	467	5	the	the	DT
cord-012902-efprpk72	467	6	sample	sample	NN
cord-012902-efprpk72	467	7	had	have	VBD
cord-012902-efprpk72	467	8	a	a	DT
cord-012902-efprpk72	467	9	salt	salt	NN
cord-012902-efprpk72	467	10	intake	intake	NN
cord-012902-efprpk72	467	11	below	below	IN
cord-012902-efprpk72	467	12	the	the	DT
cord-012902-efprpk72	467	13	World	World	NNP
cord-012902-efprpk72	467	14	Health	Health	NNP
cord-012902-efprpk72	467	15	Organization	Organization	NNP
cord-012902-efprpk72	468	1	(	(	-LRB-
cord-012902-efprpk72	468	2	WHO	who	WP
cord-012902-efprpk72	468	3	)	)	-RRB-
cord-012902-efprpk72	468	4	recommended	recommend	VBD
cord-012902-efprpk72	468	5	target	target	NN
cord-012902-efprpk72	468	6	of	of	IN
cord-012902-efprpk72	468	7	5	5	CD
cord-012902-efprpk72	468	8	g	g	NN
cord-012902-efprpk72	468	9	/	/	SYM
cord-012902-efprpk72	468	10	day	day	NN
cord-012902-efprpk72	468	11	and	and	CC
cord-012902-efprpk72	468	12	less	less	JJR
cord-012902-efprpk72	468	13	than	than	IN
cord-012902-efprpk72	468	14	a	a	DT
cord-012902-efprpk72	468	15	quarter	quarter	NN
cord-012902-efprpk72	468	16	met	meet	VBD
cord-012902-efprpk72	468	17	WHO	who	WP
cord-012902-efprpk72	468	18	targets	target	VBZ
cord-012902-efprpk72	468	19	for	for	IN
cord-012902-efprpk72	468	20	potassium	potassium	NN
cord-012902-efprpk72	468	21	excretion	excretion	NN
cord-012902-efprpk72	468	22	(	(	-LRB-
cord-012902-efprpk72	468	23	>	>	NFP
cord-012902-efprpk72	468	24	90	90	CD
cord-012902-efprpk72	468	25	mmoL	mmoL	NNP
cord-012902-efprpk72	468	26	/	/	SYM
cord-012902-efprpk72	468	27	day	day	NN
cord-012902-efprpk72	468	28	)	)	-RRB-
cord-012902-efprpk72	468	29	.	.	.
cord-012902-efprpk72	469	1	Whilst	whilst	IN
cord-012902-efprpk72	469	2	89.1	89.1	CD
cord-012902-efprpk72	469	3	%	%	NN
cord-012902-efprpk72	469	4	of	of	IN
cord-012902-efprpk72	469	5	those	those	DT
cord-012902-efprpk72	469	6	interviewed	interview	VBN
cord-012902-efprpk72	469	7	knew	know	VBD
cord-012902-efprpk72	469	8	that	that	IN
cord-012902-efprpk72	469	9	consuming	consume	VBG
cord-012902-efprpk72	469	10	too	too	RB
cord-012902-efprpk72	469	11	much	much	JJ
cord-012902-efprpk72	469	12	salt	salt	NN
cord-012902-efprpk72	469	13	could	could	MD
cord-012902-efprpk72	469	14	cause	cause	VB
cord-012902-efprpk72	469	15	serious	serious	JJ
cord-012902-efprpk72	469	16	health	health	NN
cord-012902-efprpk72	469	17	problems	problem	NNS
cord-012902-efprpk72	469	18	and	and	CC
cord-012902-efprpk72	469	19	only	only	RB
cord-012902-efprpk72	469	20	6.9	6.9	CD
cord-012902-efprpk72	469	21	%	%	NN
cord-012902-efprpk72	469	22	felt	feel	VBD
cord-012902-efprpk72	469	23	they	-PRON-	PRP
cord-012902-efprpk72	469	24	were	be	VBD
cord-012902-efprpk72	469	25	using	use	VBG
cord-012902-efprpk72	469	26	too	too	RB
cord-012902-efprpk72	469	27	much	much	JJ
cord-012902-efprpk72	469	28	added	add	VBN
cord-012902-efprpk72	469	29	salt	salt	NN
cord-012902-efprpk72	469	30	,	,	,
cord-012902-efprpk72	469	31	1	1	CD
cord-012902-efprpk72	469	32	in	in	IN
cord-012902-efprpk72	469	33	2	2	CD
cord-012902-efprpk72	469	34	participants	participant	NNS
cord-012902-efprpk72	469	35	use	use	VBP
cord-012902-efprpk72	469	36	always	always	RB
cord-012902-efprpk72	469	37	or	or	CC
cord-012902-efprpk72	469	38	often	often	RB
cord-012902-efprpk72	469	39	salt	salt	NN
cord-012902-efprpk72	469	40	,	,	,
cord-012902-efprpk72	469	41	salty	salty	JJ
cord-012902-efprpk72	469	42	seasonings	seasoning	NNS
cord-012902-efprpk72	469	43	or	or	CC
cord-012902-efprpk72	469	44	salty	salty	JJ
cord-012902-efprpk72	469	45	sauces	sauce	NNS
cord-012902-efprpk72	469	46	in	in	IN
cord-012902-efprpk72	469	47	cooking	cooking	NN
cord-012902-efprpk72	469	48	or	or	CC
cord-012902-efprpk72	469	49	when	when	WRB
cord-012902-efprpk72	469	50	preparing	prepare	VBG
cord-012902-efprpk72	469	51	food	food	NN
cord-012902-efprpk72	469	52	at	at	IN
cord-012902-efprpk72	469	53	home	home	NN
cord-012902-efprpk72	469	54	.	.	.
cord-012902-efprpk72	470	1	Conclusions	conclusion	NNS
cord-012902-efprpk72	470	2	:	:	:
cord-012902-efprpk72	471	1	In	in	IN
cord-012902-efprpk72	471	2	Oman	Oman	NNP
cord-012902-efprpk72	471	3	,	,	,
cord-012902-efprpk72	471	4	salt	salt	NN
cord-012902-efprpk72	471	5	consumption	consumption	NN
cord-012902-efprpk72	471	6	is	be	VBZ
cord-012902-efprpk72	471	7	higher	high	JJR
cord-012902-efprpk72	471	8	,	,	,
cord-012902-efprpk72	471	9	and	and	CC
cord-012902-efprpk72	471	10	potassium	potassium	NN
cord-012902-efprpk72	471	11	consumption	consumption	NN
cord-012902-efprpk72	471	12	lower	lower	RBR
cord-012902-efprpk72	471	13	,	,	,
cord-012902-efprpk72	471	14	than	than	IN
cord-012902-efprpk72	471	15	recommended	recommend	VBN
cord-012902-efprpk72	471	16	by	by	IN
cord-012902-efprpk72	471	17	the	the	DT
cord-012902-efprpk72	471	18	World	World	NNP
cord-012902-efprpk72	471	19	Health	Health	NNP
cord-012902-efprpk72	471	20	Organization	Organization	NNP
cord-012902-efprpk72	471	21	,	,	,
cord-012902-efprpk72	471	22	both	both	DT
cord-012902-efprpk72	471	23	in	in	IN
cord-012902-efprpk72	471	24	men	man	NNS
cord-012902-efprpk72	471	25	and	and	CC
cord-012902-efprpk72	471	26	in	in	IN
cord-012902-efprpk72	471	27	women	woman	NNS
cord-012902-efprpk72	471	28	.	.	.
cord-012902-efprpk72	472	1	P-18	P-18	NNP
cord-012902-efprpk72	473	1	Salt	salt	NN
cord-012902-efprpk72	473	2	Swap	Swap	NNP
cord-012902-efprpk72	473	3	:	:	:
cord-012902-efprpk72	473	4	a	a	DT
cord-012902-efprpk72	473	5	feasibility	feasibility	NN
cord-012902-efprpk72	473	6	randomised	randomise	VBN
cord-012902-efprpk72	473	7	controlled	control	VBN
cord-012902-efprpk72	473	8	trial	trial	NN
cord-012902-efprpk72	473	9	of	of	IN
cord-012902-efprpk72	473	10	a	a	DT
cord-012902-efprpk72	473	11	behavioural	behavioural	JJ
cord-012902-efprpk72	473	12	intervention	intervention	NN
cord-012902-efprpk72	473	13	to	to	TO
cord-012902-efprpk72	473	14	reduce	reduce	VB
cord-012902-efprpk72	473	15	salt	salt	NN
cord-012902-efprpk72	473	16	intake	intake	NN
cord-012902-efprpk72	473	17	among	among	IN
cord-012902-efprpk72	473	18	people	people	NNS
cord-012902-efprpk72	473	19	with	with	IN
cord-012902-efprpk72	473	20	raised	raise	VBN
cord-012902-efprpk72	473	21	blood	blood	NN
cord-012902-efprpk72	473	22	pressure	pressure	NN
cord-012902-efprpk72	473	23	Sarah	Sarah	NNP
cord-012902-efprpk72	473	24	Payne	Payne	NNP
cord-012902-efprpk72	473	25	Riches	Riches	NNP
cord-012902-efprpk72	473	26	1	1	CD
cord-012902-efprpk72	473	27	*	*	NFP
cord-012902-efprpk72	473	28	,	,	,
cord-012902-efprpk72	473	29	Mike	Mike	NNP
cord-012902-efprpk72	473	30	Rayner	Rayner	NNP
cord-012902-efprpk72	473	31	1	1	CD
cord-012902-efprpk72	473	32	,	,	,
cord-012902-efprpk72	473	33	Carmen	Carmen	NNP
cord-012902-efprpk72	473	34	Piernas	Piernas	NNP
cord-012902-efprpk72	473	35	1	1	CD
cord-012902-efprpk72	473	36	,	,	,
cord-012902-efprpk72	473	37	Paul	Paul	NNP
cord-012902-efprpk72	473	38	Aveyard	Aveyard	NNP
cord-012902-efprpk72	473	39	1	1	CD
cord-012902-efprpk72	473	40	,	,	,
cord-012902-efprpk72	473	41	James	James	NNP
cord-012902-efprpk72	473	42	Shepard	Shepard	NNP
cord-012902-efprpk72	473	43	1	1	CD
cord-012902-efprpk72	473	44	,	,	,
cord-012902-efprpk72	473	45	Charlotte	Charlotte	NNP
cord-012902-efprpk72	473	46	Albury	Albury	NNP
cord-012902-efprpk72	473	47	1	1	CD
cord-012902-efprpk72	473	48	,	,	,
cord-012902-efprpk72	473	49	Susan	Susan	NNP
cord-012902-efprpk72	473	50	Jebb	Jebb	NNP
cord-012902-efprpk72	473	51	1	1	CD
cord-012902-efprpk72	473	52	1	1	CD
cord-012902-efprpk72	473	53	University	University	NNP
cord-012902-efprpk72	473	54	of	of	IN
cord-012902-efprpk72	473	55	Oxford	Oxford	NNP
cord-012902-efprpk72	473	56	,	,	,
cord-012902-efprpk72	473	57	Oxford	Oxford	NNP
cord-012902-efprpk72	473	58	,	,	,
cord-012902-efprpk72	474	1	UK	UK	NNP
cord-012902-efprpk72	474	2	Introduction	introduction	NN
cord-012902-efprpk72	474	3	:	:	:
cord-012902-efprpk72	475	1	High	high	JJ
cord-012902-efprpk72	475	2	salt	salt	NN
cord-012902-efprpk72	475	3	intake	intake	NN
cord-012902-efprpk72	475	4	is	be	VBZ
cord-012902-efprpk72	475	5	a	a	DT
cord-012902-efprpk72	475	6	risk	risk	NN
cord-012902-efprpk72	475	7	factor	factor	NN
cord-012902-efprpk72	475	8	for	for	IN
cord-012902-efprpk72	475	9	hypertension	hypertension	NN
cord-012902-efprpk72	475	10	.	.	.
cord-012902-efprpk72	476	1	We	-PRON-	PRP
cord-012902-efprpk72	476	2	examined	examine	VBD
cord-012902-efprpk72	476	3	the	the	DT
cord-012902-efprpk72	476	4	feasibility	feasibility	NN
cord-012902-efprpk72	476	5	of	of	IN
cord-012902-efprpk72	476	6	a	a	DT
cord-012902-efprpk72	476	7	novel	novel	JJ
cord-012902-efprpk72	476	8	intervention	intervention	NN
cord-012902-efprpk72	476	9	to	to	TO
cord-012902-efprpk72	476	10	encourage	encourage	VB
cord-012902-efprpk72	476	11	individuals	individual	NNS
cord-012902-efprpk72	476	12	with	with	IN
cord-012902-efprpk72	476	13	raised	raise	VBN
cord-012902-efprpk72	476	14	blood	blood	NN
cord-012902-efprpk72	476	15	pressure	pressure	NN
cord-012902-efprpk72	476	16	to	to	TO
cord-012902-efprpk72	476	17	reduce	reduce	VB
cord-012902-efprpk72	476	18	their	-PRON-	PRP$
cord-012902-efprpk72	476	19	salt	salt	NN
cord-012902-efprpk72	476	20	intake	intake	NN
cord-012902-efprpk72	476	21	by	by	IN
cord-012902-efprpk72	476	22	purchasing	purchase	VBG
cord-012902-efprpk72	476	23	lower	low	JJR
cord-012902-efprpk72	476	24	-	-	HYPH
cord-012902-efprpk72	476	25	salt	salt	NN
cord-012902-efprpk72	476	26	products	product	NNS
cord-012902-efprpk72	476	27	when	when	WRB
cord-012902-efprpk72	476	28	grocery	grocery	NN
cord-012902-efprpk72	476	29	shopping	shopping	NN
cord-012902-efprpk72	476	30	.	.	.
cord-012902-efprpk72	477	1	Methods	method	NNS
cord-012902-efprpk72	477	2	:	:	:
cord-012902-efprpk72	477	3	Forty	forty	CD
cord-012902-efprpk72	477	4	-	-	HYPH
cord-012902-efprpk72	477	5	seven	seven	CD
cord-012902-efprpk72	477	6	adults	adult	NNS
cord-012902-efprpk72	477	7	with	with	IN
cord-012902-efprpk72	477	8	a	a	DT
cord-012902-efprpk72	477	9	record	record	NN
cord-012902-efprpk72	477	10	of	of	IN
cord-012902-efprpk72	477	11	high	high	JJ
cord-012902-efprpk72	477	12	blood	blood	NN
cord-012902-efprpk72	477	13	pressure	pressure	NN
cord-012902-efprpk72	477	14	were	be	VBD
cord-012902-efprpk72	477	15	recruited	recruit	VBN
cord-012902-efprpk72	477	16	from	from	IN
cord-012902-efprpk72	477	17	GP	GP	NNP
cord-012902-efprpk72	477	18	practices	practice	NNS
cord-012902-efprpk72	477	19	and	and	CC
cord-012902-efprpk72	477	20	randomised	randomise	VBD
cord-012902-efprpk72	477	21	to	to	TO
cord-012902-efprpk72	477	22	receive	receive	VB
cord-012902-efprpk72	477	23	the	the	DT
cord-012902-efprpk72	477	24	intervention	intervention	NN
cord-012902-efprpk72	477	25	(	(	-LRB-
cord-012902-efprpk72	477	26	n	n	NN
cord-012902-efprpk72	477	27	=	=	SYM
cord-012902-efprpk72	477	28	31	31	CD
cord-012902-efprpk72	477	29	)	)	-RRB-
cord-012902-efprpk72	477	30	;	;	:
cord-012902-efprpk72	477	31	or	or	CC
cord-012902-efprpk72	477	32	a	a	DT
cord-012902-efprpk72	477	33	generic	generic	JJ
cord-012902-efprpk72	477	34	saltreduction	saltreduction	NN
cord-012902-efprpk72	477	35	advice	advice	NN
cord-012902-efprpk72	477	36	leaflet	leaflet	NN
cord-012902-efprpk72	477	37	(	(	-LRB-
cord-012902-efprpk72	477	38	control	control	NN
cord-012902-efprpk72	477	39	,	,	,
cord-012902-efprpk72	477	40	n	n	NN
cord-012902-efprpk72	477	41	=	=	SYM
cord-012902-efprpk72	477	42	16	16	CD
cord-012902-efprpk72	477	43	)	)	-RRB-
cord-012902-efprpk72	477	44	.	.	.
cord-012902-efprpk72	478	1	The	the	DT
cord-012902-efprpk72	478	2	intervention	intervention	NN
cord-012902-efprpk72	478	3	comprised	comprise	VBD
cord-012902-efprpk72	478	4	a	a	DT
cord-012902-efprpk72	478	5	30-min	30-min	CD
cord-012902-efprpk72	478	6	behavioural	behavioural	JJ
cord-012902-efprpk72	478	7	support	support	NN
cord-012902-efprpk72	478	8	session	session	NN
cord-012902-efprpk72	478	9	with	with	IN
cord-012902-efprpk72	478	10	a	a	DT
cord-012902-efprpk72	478	11	healthcare	healthcare	NN
cord-012902-efprpk72	478	12	practitioner	practitioner	NN
cord-012902-efprpk72	478	13	in	in	IN
cord-012902-efprpk72	478	14	primary	primary	JJ
cord-012902-efprpk72	478	15	care	care	NN
cord-012902-efprpk72	478	16	and	and	CC
cord-012902-efprpk72	478	17	use	use	NN
cord-012902-efprpk72	478	18	of	of	IN
cord-012902-efprpk72	478	19	a	a	DT
cord-012902-efprpk72	478	20	theoretically	theoretically	RB
cord-012902-efprpk72	478	21	-	-	HYPH
cord-012902-efprpk72	478	22	informed	inform	VBN
cord-012902-efprpk72	478	23	smartphone	smartphone	NN
cord-012902-efprpk72	478	24	app	app	NN
cord-012902-efprpk72	478	25	(	(	-LRB-
cord-012902-efprpk72	478	26	Salt	Salt	NNP
cord-012902-efprpk72	478	27	-	-	HYPH
cord-012902-efprpk72	478	28	Swap	Swap	NNP
cord-012902-efprpk72	478	29	)	)	-RRB-
cord-012902-efprpk72	478	30	to	to	TO
cord-012902-efprpk72	478	31	help	help	VB
cord-012902-efprpk72	478	32	participants	participant	NNS
cord-012902-efprpk72	478	33	choose	choose	VB
cord-012902-efprpk72	478	34	lower	low	JJR
cord-012902-efprpk72	478	35	-	-	HYPH
cord-012902-efprpk72	478	36	salt	salt	NN
cord-012902-efprpk72	478	37	foods	food	NNS
cord-012902-efprpk72	478	38	when	when	WRB
cord-012902-efprpk72	478	39	grocery	grocery	NN
cord-012902-efprpk72	478	40	shopping	shopping	NN
cord-012902-efprpk72	478	41	.	.	.
cord-012902-efprpk72	479	1	Primary	primary	JJ
cord-012902-efprpk72	479	2	outcomes	outcome	NNS
cord-012902-efprpk72	479	3	were	be	VBD
cord-012902-efprpk72	479	4	progression	progression	NN
cord-012902-efprpk72	479	5	criteria	criterion	NNS
cord-012902-efprpk72	479	6	for	for	IN
cord-012902-efprpk72	479	7	a	a	DT
cord-012902-efprpk72	479	8	larger	large	JJR
cord-012902-efprpk72	479	9	trial	trial	NN
cord-012902-efprpk72	479	10	:	:	:
cord-012902-efprpk72	479	11	follow	follow	VB
cord-012902-efprpk72	479	12	-	-	HYPH
cord-012902-efprpk72	479	13	up	up	RP
cord-012902-efprpk72	479	14	attendance	attendance	NN
cord-012902-efprpk72	479	15	,	,	,
cord-012902-efprpk72	479	16	use	use	NN
cord-012902-efprpk72	479	17	of	of	IN
cord-012902-efprpk72	479	18	the	the	DT
cord-012902-efprpk72	479	19	Salt	Salt	NNP
cord-012902-efprpk72	479	20	-	-	HYPH
cord-012902-efprpk72	479	21	Swap	Swap	NNP
cord-012902-efprpk72	479	22	app	app	NN
cord-012902-efprpk72	479	23	and	and	CC
cord-012902-efprpk72	479	24	fidelity	fidelity	NN
cord-012902-efprpk72	479	25	of	of	IN
cord-012902-efprpk72	479	26	intervention	intervention	NN
cord-012902-efprpk72	479	27	delivery	delivery	NN
cord-012902-efprpk72	479	28	.	.	.
cord-012902-efprpk72	480	1	Secondary	secondary	JJ
cord-012902-efprpk72	480	2	outcomes	outcome	NNS
cord-012902-efprpk72	480	3	included	include	VBD
cord-012902-efprpk72	480	4	change	change	NN
cord-012902-efprpk72	480	5	in	in	IN
cord-012902-efprpk72	480	6	salt	salt	NN
cord-012902-efprpk72	480	7	intake	intake	NN
cord-012902-efprpk72	480	8	(	(	-LRB-
cord-012902-efprpk72	480	9	24-h	24-h	JJ
cord-012902-efprpk72	480	10	urinary	urinary	JJ
cord-012902-efprpk72	480	11	sodium	sodium	NN
cord-012902-efprpk72	480	12	)	)	-RRB-
cord-012902-efprpk72	480	13	and	and	CC
cord-012902-efprpk72	480	14	blood	blood	NN
cord-012902-efprpk72	480	15	pressure	pressure	NN
cord-012902-efprpk72	480	16	after	after	IN
cord-012902-efprpk72	480	17	six	six	CD
cord-012902-efprpk72	480	18	weeks	week	NNS
cord-012902-efprpk72	480	19	.	.	.
cord-012902-efprpk72	481	1	A	a	DT
cord-012902-efprpk72	481	2	qualitative	qualitative	JJ
cord-012902-efprpk72	481	3	assessment	assessment	NN
cord-012902-efprpk72	481	4	was	be	VBD
cord-012902-efprpk72	481	5	conducted	conduct	VBN
cord-012902-efprpk72	481	6	in	in	IN
cord-012902-efprpk72	481	7	a	a	DT
cord-012902-efprpk72	481	8	subgroup	subgroup	NN
cord-012902-efprpk72	481	9	,	,	,
cord-012902-efprpk72	481	10	using	use	VBG
cord-012902-efprpk72	481	11	the	the	DT
cord-012902-efprpk72	481	12	think	think	NN
cord-012902-efprpk72	481	13	-	-	HYPH
cord-012902-efprpk72	481	14	aloud	aloud	RB
cord-012902-efprpk72	481	15	method	method	NN
cord-012902-efprpk72	481	16	and	and	CC
cord-012902-efprpk72	481	17	semi	semi	JJ
cord-012902-efprpk72	481	18	-	-	JJ
cord-012902-efprpk72	481	19	structured	structured	JJ
cord-012902-efprpk72	481	20	interviews	interview	NNS
cord-012902-efprpk72	481	21	.	.	.
cord-012902-efprpk72	482	1	Results	result	NNS
cord-012902-efprpk72	482	2	:	:	:
cord-012902-efprpk72	483	1	Progression	progression	NN
cord-012902-efprpk72	483	2	criteria	criterion	NNS
cord-012902-efprpk72	483	3	were	be	VBD
cord-012902-efprpk72	483	4	met	meet	VBN
cord-012902-efprpk72	483	5	,	,	,
cord-012902-efprpk72	483	6	with	with	IN
cord-012902-efprpk72	483	7	96	96	CD
cord-012902-efprpk72	483	8	%	%	NN
cord-012902-efprpk72	483	9	(	(	-LRB-
cord-012902-efprpk72	483	10	45/47	45/47	CD
cord-012902-efprpk72	483	11	)	)	-RRB-
cord-012902-efprpk72	483	12	follow	follow	NN
cord-012902-efprpk72	483	13	-	-	HYPH
cord-012902-efprpk72	483	14	up	up	NN
cord-012902-efprpk72	483	15	,	,	,
cord-012902-efprpk72	483	16	87	87	CD
cord-012902-efprpk72	483	17	%	%	NN
cord-012902-efprpk72	483	18	(	(	-LRB-
cord-012902-efprpk72	483	19	27/31	27/31	CD
cord-012902-efprpk72	483	20	)	)	-RRB-
cord-012902-efprpk72	483	21	of	of	IN
cord-012902-efprpk72	483	22	intervention	intervention	NN
cord-012902-efprpk72	483	23	participants	participant	NNS
cord-012902-efprpk72	483	24	using	use	VBG
cord-012902-efprpk72	483	25	the	the	DT
cord-012902-efprpk72	483	26	app	app	NN
cord-012902-efprpk72	483	27	more	more	JJR
cord-012902-efprpk72	483	28	than	than	IN
cord-012902-efprpk72	483	29	once	once	RB
cord-012902-efprpk72	483	30	in	in	IN
cord-012902-efprpk72	483	31	month	month	NN
cord-012902-efprpk72	483	32	one	one	CD
cord-012902-efprpk72	483	33	,	,	,
cord-012902-efprpk72	483	34	and	and	CC
cord-012902-efprpk72	483	35	81	81	CD
cord-012902-efprpk72	483	36	%	%	NN
cord-012902-efprpk72	483	37	fidelity	fidelity	NN
cord-012902-efprpk72	483	38	of	of	IN
cord-012902-efprpk72	483	39	intervention	intervention	NN
cord-012902-efprpk72	483	40	delivery	delivery	NN
cord-012902-efprpk72	483	41	.	.	.
cord-012902-efprpk72	484	1	Salt	salt	NN
cord-012902-efprpk72	484	2	intake	intake	NN
cord-012902-efprpk72	484	3	decreased	decrease	VBD
cord-012902-efprpk72	484	4	in	in	IN
cord-012902-efprpk72	484	5	both	both	DT
cord-012902-efprpk72	484	6	groups	group	NNS
cord-012902-efprpk72	484	7	,	,	,
cord-012902-efprpk72	485	1	(	(	-LRB-
cord-012902-efprpk72	485	2	intervention	intervention	NN
cord-012902-efprpk72	485	3	−0.2g	−0.2g	NNP
cord-012902-efprpk72	485	4	/	/	SYM
cord-012902-efprpk72	485	5	d	d	XX
cord-012902-efprpk72	485	6	,	,	,
cord-012902-efprpk72	485	7	95	95	CD
cord-012902-efprpk72	485	8	%	%	NN
cord-012902-efprpk72	485	9	CI	ci	NN
cord-012902-efprpk72	485	10	−1.4	−1.4	NN
cord-012902-efprpk72	485	11	to	to	IN
cord-012902-efprpk72	485	12	0.9	0.9	CD
cord-012902-efprpk72	485	13	;	;	,
cord-012902-efprpk72	485	14	control	control	VB
cord-012902-efprpk72	485	15	−1.0	−1.0	NNP
cord-012902-efprpk72	485	16	g	g	NN
cord-012902-efprpk72	485	17	/	/	SYM
cord-012902-efprpk72	485	18	d	d	NN
cord-012902-efprpk72	485	19	,	,	,
cord-012902-efprpk72	485	20	95	95	CD
cord-012902-efprpk72	485	21	%	%	NN
cord-012902-efprpk72	485	22	CI	CI	NNP
cord-012902-efprpk72	485	23	−2.4	−2.4	NN
cord-012902-efprpk72	485	24	to	to	IN
cord-012902-efprpk72	485	25	0.4	0.4	CD
cord-012902-efprpk72	485	26	)	)	-RRB-
cord-012902-efprpk72	485	27	as	as	IN
cord-012902-efprpk72	485	28	did	do	VBD
cord-012902-efprpk72	485	29	systolic	systolic	JJ
cord-012902-efprpk72	485	30	blood	blood	NN
cord-012902-efprpk72	485	31	pressure	pressure	NN
cord-012902-efprpk72	485	32	(	(	-LRB-
cord-012902-efprpk72	485	33	intervention	intervention	NN
cord-012902-efprpk72	485	34	−1.0	−1.0	NN
cord-012902-efprpk72	485	35	mmHg	mmHg	NNP
cord-012902-efprpk72	485	36	,	,	,
cord-012902-efprpk72	485	37	95	95	CD
cord-012902-efprpk72	485	38	%	%	NN
cord-012902-efprpk72	485	39	CI	ci	NN
cord-012902-efprpk72	485	40	−5.5	−5.5	NNP
cord-012902-efprpk72	485	41	to	to	IN
cord-012902-efprpk72	485	42	3.6	3.6	CD
cord-012902-efprpk72	485	43	;	;	:
cord-012902-efprpk72	485	44	control	control	NN
cord-012902-efprpk72	485	45	−1.1	−1.1	NN
cord-012902-efprpk72	485	46	mmHg	mmhg	NN
cord-012902-efprpk72	485	47	,	,	,
cord-012902-efprpk72	485	48	95	95	CD
cord-012902-efprpk72	485	49	%	%	NN
cord-012902-efprpk72	485	50	CI	CI	NNP
cord-012902-efprpk72	485	51	−6.7	−6.7	NNP
cord-012902-efprpk72	485	52	to	to	IN
cord-012902-efprpk72	485	53	4.4	4.4	CD
cord-012902-efprpk72	485	54	)	)	-RRB-
cord-012902-efprpk72	485	55	.	.	.
cord-012902-efprpk72	486	1	There	there	EX
cord-012902-efprpk72	486	2	was	be	VBD
cord-012902-efprpk72	486	3	no	no	DT
cord-012902-efprpk72	486	4	significant	significant	JJ
cord-012902-efprpk72	486	5	difference	difference	NN
cord-012902-efprpk72	486	6	between	between	IN
cord-012902-efprpk72	486	7	groups	group	NNS
cord-012902-efprpk72	486	8	.	.	.
cord-012902-efprpk72	487	1	Seventeen	seventeen	CD
cord-012902-efprpk72	487	2	participants	participant	NNS
cord-012902-efprpk72	487	3	completed	complete	VBD
cord-012902-efprpk72	487	4	a	a	DT
cord-012902-efprpk72	487	5	think	think	NN
cord-012902-efprpk72	487	6	-	-	HYPH
cord-012902-efprpk72	487	7	aloud	aloud	RB
cord-012902-efprpk72	487	8	shop	shop	NN
cord-012902-efprpk72	487	9	and	and	CC
cord-012902-efprpk72	487	10	interview	interview	NN
cord-012902-efprpk72	487	11	.	.	.
cord-012902-efprpk72	488	1	Salt	Salt	NNP
cord-012902-efprpk72	488	2	-	-	HYPH
cord-012902-efprpk72	488	3	Swap	swap	NN
cord-012902-efprpk72	488	4	increased	increase	VBD
cord-012902-efprpk72	488	5	participants	participant	NNS
cord-012902-efprpk72	488	6	'	'	POS
cord-012902-efprpk72	488	7	knowledge	knowledge	NN
cord-012902-efprpk72	488	8	of	of	IN
cord-012902-efprpk72	488	9	the	the	DT
cord-012902-efprpk72	488	10	sources	source	NNS
cord-012902-efprpk72	488	11	of	of	IN
cord-012902-efprpk72	488	12	dietary	dietary	JJ
cord-012902-efprpk72	488	13	salt	salt	NN
cord-012902-efprpk72	488	14	,	,	,
cord-012902-efprpk72	488	15	their	-PRON-	PRP$
cord-012902-efprpk72	488	16	use	use	NN
cord-012902-efprpk72	488	17	product	product	NN
cord-012902-efprpk72	488	18	nutrition	nutrition	NN
cord-012902-efprpk72	488	19	labels	label	NNS
cord-012902-efprpk72	488	20	for	for	IN
cord-012902-efprpk72	488	21	salt	salt	NN
cord-012902-efprpk72	488	22	,	,	,
cord-012902-efprpk72	488	23	and	and	CC
cord-012902-efprpk72	488	24	changed	change	VBD
cord-012902-efprpk72	488	25	purchasing	purchasing	NN
cord-012902-efprpk72	488	26	behaviours	behaviour	NNS
cord-012902-efprpk72	488	27	that	that	WDT
cord-012902-efprpk72	488	28	could	could	MD
cord-012902-efprpk72	488	29	help	help	VB
cord-012902-efprpk72	488	30	to	to	TO
cord-012902-efprpk72	488	31	reduce	reduce	VB
cord-012902-efprpk72	488	32	salt	salt	NN
cord-012902-efprpk72	488	33	intake	intake	NN
cord-012902-efprpk72	488	34	.	.	.
cord-012902-efprpk72	489	1	Conclusions	conclusion	NNS
cord-012902-efprpk72	489	2	:	:	:
cord-012902-efprpk72	490	1	It	-PRON-	PRP
cord-012902-efprpk72	490	2	would	would	MD
cord-012902-efprpk72	490	3	be	be	VB
cord-012902-efprpk72	490	4	feasible	feasible	JJ
cord-012902-efprpk72	490	5	to	to	TO
cord-012902-efprpk72	490	6	conduct	conduct	VB
cord-012902-efprpk72	490	7	a	a	DT
cord-012902-efprpk72	490	8	definitive	definitive	JJ
cord-012902-efprpk72	490	9	trial	trial	NN
cord-012902-efprpk72	490	10	to	to	TO
cord-012902-efprpk72	490	11	assess	assess	VB
cord-012902-efprpk72	490	12	effects	effect	NNS
cord-012902-efprpk72	490	13	on	on	IN
cord-012902-efprpk72	490	14	blood	blood	NN
cord-012902-efprpk72	490	15	pressure	pressure	NN
cord-012902-efprpk72	490	16	.	.	.
cord-012902-efprpk72	491	1	The	the	DT
cord-012902-efprpk72	491	2	app	app	NN
cord-012902-efprpk72	491	3	was	be	VBD
cord-012902-efprpk72	491	4	popular	popular	JJ
cord-012902-efprpk72	491	5	among	among	IN
cord-012902-efprpk72	491	6	participants	participant	NNS
cord-012902-efprpk72	491	7	,	,	,
cord-012902-efprpk72	491	8	but	but	CC
cord-012902-efprpk72	491	9	the	the	DT
cord-012902-efprpk72	491	10	usefulness	usefulness	NN
cord-012902-efprpk72	491	11	could	could	MD
cord-012902-efprpk72	491	12	be	be	VB
cord-012902-efprpk72	491	13	increased	increase	VBN
cord-012902-efprpk72	491	14	by	by	IN
cord-012902-efprpk72	491	15	improving	improve	VBG
cord-012902-efprpk72	491	16	product	product	NN
cord-012902-efprpk72	491	17	coverage	coverage	NN
cord-012902-efprpk72	491	18	of	of	IN
cord-012902-efprpk72	491	19	the	the	DT
cord-012902-efprpk72	491	20	Salt	Salt	NNP
cord-012902-efprpk72	491	21	-	-	HYPH
cord-012902-efprpk72	491	22	Swap	Swap	NNP
cord-012902-efprpk72	491	23	app	app	NN
cord-012902-efprpk72	491	24	.	.	.
cord-012902-efprpk72	492	1	P-19	P-19	NNP
cord-012902-efprpk72	492	2	Effect	effect	NN
cord-012902-efprpk72	492	3	of	of	IN
cord-012902-efprpk72	492	4	dietary	dietary	JJ
cord-012902-efprpk72	492	5	salt	salt	NN
cord-012902-efprpk72	492	6	reduction	reduction	NN
cord-012902-efprpk72	492	7	on	on	IN
cord-012902-efprpk72	492	8	blood	blood	NN
cord-012902-efprpk72	492	9	pressure	pressure	NN
cord-012902-efprpk72	492	10	in	in	IN
cord-012902-efprpk72	492	11	kidney	kidney	NN
cord-012902-efprpk72	492	12	transplant	transplant	NN
cord-012902-efprpk72	492	13	patients	patient	NNS
cord-012902-efprpk72	492	14	:	:	:
cord-012902-efprpk72	492	15	a	a	DT
cord-012902-efprpk72	492	16	randomised	randomised	JJ
cord-012902-efprpk72	492	17	controlled	control	VBN
cord-012902-efprpk72	492	18	trial	trial	NN
cord-012902-efprpk72	492	19	Louise	Louise	NNP
cord-012902-efprpk72	492	20	Ross	Ross	NNP
cord-012902-efprpk72	492	21	1	1	CD
cord-012902-efprpk72	492	22	,	,	,
cord-012902-efprpk72	492	23	Rebecca	Rebecca	NNP
cord-012902-efprpk72	492	24	Suckling	Suckling	NNP
cord-012902-efprpk72	492	25	1	1	CD
cord-012902-efprpk72	492	26	,	,	,
cord-012902-efprpk72	492	27	Mark	Mark	NNP
cord-012902-efprpk72	492	28	Dockrell	Dockrell	NNP
cord-012902-efprpk72	492	29	1	1	CD
cord-012902-efprpk72	492	30	,	,	,
cord-012902-efprpk72	493	1	Feng	Feng	NNP
cord-012902-efprpk72	493	2	He	He	NNP
cord-012902-efprpk72	493	3	2	2	CD
cord-012902-efprpk72	493	4	,	,	,
cord-012902-efprpk72	493	5	Thomas	Thomas	NNP
cord-012902-efprpk72	493	6	Bailey	Bailey	NNP
cord-012902-efprpk72	493	7	3	3	CD
cord-012902-efprpk72	493	8	,	,	,
cord-012902-efprpk72	493	9	Pauline	Pauline	NNP
cord-012902-efprpk72	493	10	Swift	Swift	NNP
cord-012902-efprpk72	493	11	1	1	CD
cord-012902-efprpk72	494	1	*	*	NFP
cord-012902-efprpk72	494	2	Introduction	introduction	NN
cord-012902-efprpk72	494	3	:	:	:
cord-012902-efprpk72	494	4	Strict	strict	JJ
cord-012902-efprpk72	494	5	vegetarian	vegetarian	JJ
cord-012902-efprpk72	494	6	diets	diet	NNS
cord-012902-efprpk72	494	7	with	with	IN
cord-012902-efprpk72	494	8	no	no	DT
cord-012902-efprpk72	494	9	animal	animal	NN
cord-012902-efprpk72	494	10	products	product	NNS
cord-012902-efprpk72	494	11	are	be	VBP
cord-012902-efprpk72	494	12	associated	associate	VBN
cord-012902-efprpk72	494	13	with	with	IN
cord-012902-efprpk72	494	14	low	low	JJ
cord-012902-efprpk72	494	15	blood	blood	NN
cord-012902-efprpk72	494	16	pressure	pressure	NN
cord-012902-efprpk72	494	17	(	(	-LRB-
cord-012902-efprpk72	494	18	BP	BP	NNP
cord-012902-efprpk72	494	19	)	)	-RRB-
cord-012902-efprpk72	494	20	.	.	.
cord-012902-efprpk72	495	1	(	(	-LRB-
cord-012902-efprpk72	495	2	1	1	LS
cord-012902-efprpk72	495	3	)	)	-RRB-
cord-012902-efprpk72	495	4	It	-PRON-	PRP
cord-012902-efprpk72	495	5	is	be	VBZ
cord-012902-efprpk72	495	6	not	not	RB
cord-012902-efprpk72	495	7	clear	clear	JJ
cord-012902-efprpk72	495	8	whether	whether	IN
cord-012902-efprpk72	495	9	less	less	RBR
cord-012902-efprpk72	495	10	strict	strict	JJ
cord-012902-efprpk72	495	11	plant	plant	NN
cord-012902-efprpk72	495	12	-	-	HYPH
cord-012902-efprpk72	495	13	based	base	VBN
cord-012902-efprpk72	495	14	diets	diet	NNS
cord-012902-efprpk72	495	15	(	(	-LRB-
cord-012902-efprpk72	495	16	PBD	PBD	NNP
cord-012902-efprpk72	495	17	)	)	-RRB-
cord-012902-efprpk72	495	18	exert	exert	VB
cord-012902-efprpk72	495	19	similar	similar	JJ
cord-012902-efprpk72	495	20	effects	effect	NNS
cord-012902-efprpk72	495	21	.	.	.
cord-012902-efprpk72	496	1	We	-PRON-	PRP
cord-012902-efprpk72	496	2	assessed	assess	VBD
cord-012902-efprpk72	496	3	whether	whether	IN
cord-012902-efprpk72	496	4	less	less	RBR
cord-012902-efprpk72	496	5	strict	strict	JJ
cord-012902-efprpk72	496	6	PBDs	pbd	NNS
cord-012902-efprpk72	496	7	reduce	reduce	VBP
cord-012902-efprpk72	496	8	BP	BP	NNP
cord-012902-efprpk72	496	9	in	in	IN
cord-012902-efprpk72	496	10	controlled	control	VBN
cord-012902-efprpk72	496	11	clinical	clinical	JJ
cord-012902-efprpk72	496	12	trials	trial	NNS
cord-012902-efprpk72	496	13	.	.	.
cord-012902-efprpk72	497	1	Methods	method	NNS
cord-012902-efprpk72	497	2	:	:	:
cord-012902-efprpk72	497	3	We	-PRON-	PRP
cord-012902-efprpk72	497	4	carried	carry	VBD
cord-012902-efprpk72	497	5	out	out	RP
cord-012902-efprpk72	497	6	a	a	DT
cord-012902-efprpk72	497	7	systematic	systematic	JJ
cord-012902-efprpk72	497	8	review	review	NN
cord-012902-efprpk72	497	9	and	and	CC
cord-012902-efprpk72	497	10	a	a	DT
cord-012902-efprpk72	497	11	metaanalysis	metaanalysis	NN
cord-012902-efprpk72	497	12	of	of	IN
cord-012902-efprpk72	497	13	all	all	DT
cord-012902-efprpk72	497	14	published	publish	VBN
cord-012902-efprpk72	497	15	intervention	intervention	NN
cord-012902-efprpk72	497	16	trials	trial	NNS
cord-012902-efprpk72	497	17	assessing	assess	VBG
cord-012902-efprpk72	497	18	the	the	DT
cord-012902-efprpk72	497	19	effects	effect	NNS
cord-012902-efprpk72	497	20	of	of	IN
cord-012902-efprpk72	497	21	PBDs	pbd	NNS
cord-012902-efprpk72	497	22	on	on	IN
cord-012902-efprpk72	497	23	BP	BP	NNP
cord-012902-efprpk72	497	24	.	.	.
cord-012902-efprpk72	498	1	On	on	IN
cord-012902-efprpk72	498	2	14	14	CD
cord-012902-efprpk72	498	3	June	June	NNP
cord-012902-efprpk72	498	4	2019	2019	CD
cord-012902-efprpk72	498	5	we	-PRON-	PRP
cord-012902-efprpk72	498	6	performed	perform	VBD
cord-012902-efprpk72	498	7	a	a	DT
cord-012902-efprpk72	498	8	systematic	systematic	JJ
cord-012902-efprpk72	498	9	search	search	NN
cord-012902-efprpk72	498	10	of	of	IN
cord-012902-efprpk72	498	11	publications	publication	NNS
cord-012902-efprpk72	498	12	using	use	VBG
cord-012902-efprpk72	498	13	MEDLINE	MEDLINE	NNP
cord-012902-efprpk72	498	14	,	,	,
cord-012902-efprpk72	498	15	EMBASE	EMBASE	NNP
cord-012902-efprpk72	498	16	(	(	-LRB-
cord-012902-efprpk72	498	17	from	from	IN
cord-012902-efprpk72	498	18	1980	1980	CD
cord-012902-efprpk72	498	19	)	)	-RRB-
cord-012902-efprpk72	498	20	,	,	,
cord-012902-efprpk72	498	21	CINHAL	CINHAL	NNP
cord-012902-efprpk72	498	22	,	,	,
cord-012902-efprpk72	498	23	WoS	WoS	NNP
cord-012902-efprpk72	498	24	and	and	CC
cord-012902-efprpk72	498	25	manual	manual	JJ
cord-012902-efprpk72	498	26	searches	search	NNS
cord-012902-efprpk72	498	27	without	without	IN
cord-012902-efprpk72	498	28	language	language	NN
cord-012902-efprpk72	498	29	restrictions	restriction	NNS
cord-012902-efprpk72	498	30	.	.	.
cord-012902-efprpk72	499	1	Inclusion	inclusion	NN
cord-012902-efprpk72	499	2	criteria	criterion	NNS
cord-012902-efprpk72	499	3	were	be	VBD
cord-012902-efprpk72	499	4	age	age	NN
cord-012902-efprpk72	499	5	≥	≥	CD
cord-012902-efprpk72	499	6	18	18	CD
cord-012902-efprpk72	499	7	years	year	NNS
cord-012902-efprpk72	499	8	,	,	,
cord-012902-efprpk72	499	9	PBD	PBD	NNP
cord-012902-efprpk72	499	10	as	as	IN
cord-012902-efprpk72	499	11	an	an	DT
cord-012902-efprpk72	499	12	intervention	intervention	NN
cord-012902-efprpk72	499	13	,	,	,
cord-012902-efprpk72	499	14	defined	define	VBN
cord-012902-efprpk72	499	15	as	as	IN
cord-012902-efprpk72	499	16	dietary	dietary	JJ
cord-012902-efprpk72	499	17	patterns	pattern	NNS
cord-012902-efprpk72	499	18	that	that	WDT
cord-012902-efprpk72	499	19	support	support	VBP
cord-012902-efprpk72	499	20	high	high	JJ
cord-012902-efprpk72	499	21	consumption	consumption	NN
cord-012902-efprpk72	499	22	of	of	IN
cord-012902-efprpk72	499	23	fruits	fruit	NNS
cord-012902-efprpk72	499	24	,	,	,
cord-012902-efprpk72	499	25	vegetables	vegetable	NNS
cord-012902-efprpk72	499	26	,	,	,
cord-012902-efprpk72	499	27	whole	whole	JJ
cord-012902-efprpk72	499	28	grains	grain	NNS
cord-012902-efprpk72	499	29	,	,	,
cord-012902-efprpk72	499	30	legumes	legume	NNS
cord-012902-efprpk72	499	31	,	,	,
cord-012902-efprpk72	499	32	nuts	nut	NNS
cord-012902-efprpk72	499	33	and	and	CC
cord-012902-efprpk72	499	34	seeds	seed	NNS
cord-012902-efprpk72	499	35	,	,	,
cord-012902-efprpk72	499	36	and	and	CC
cord-012902-efprpk72	499	37	avoid	avoid	VB
cord-012902-efprpk72	499	38	the	the	DT
cord-012902-efprpk72	499	39	consumption	consumption	NN
cord-012902-efprpk72	499	40	of	of	IN
cord-012902-efprpk72	499	41	most	most	JJS
cord-012902-efprpk72	499	42	or	or	CC
cord-012902-efprpk72	499	43	all	all	DT
cord-012902-efprpk72	499	44	animal	animal	NN
cord-012902-efprpk72	499	45	products	product	NNS
cord-012902-efprpk72	499	46	,	,	,
cord-012902-efprpk72	499	47	mean	mean	VBP
cord-012902-efprpk72	499	48	differences	difference	NNS
cord-012902-efprpk72	499	49	in	in	IN
cord-012902-efprpk72	499	50	systolic	systolic	JJ
cord-012902-efprpk72	499	51	/	/	SYM
cord-012902-efprpk72	499	52	diastolic	diastolic	JJ
cord-012902-efprpk72	499	53	BP	BP	NNP
cord-012902-efprpk72	499	54	between	between	IN
cord-012902-efprpk72	499	55	PBD	PBD	NNP
cord-012902-efprpk72	499	56	and	and	CC
cord-012902-efprpk72	499	57	control	control	NN
cord-012902-efprpk72	499	58	diet	diet	NN
cord-012902-efprpk72	499	59	,	,	,
cord-012902-efprpk72	499	60	controlled	control	VBN
cord-012902-efprpk72	499	61	clinical	clinical	JJ
cord-012902-efprpk72	499	62	trial	trial	NN
cord-012902-efprpk72	499	63	.	.	.
cord-012902-efprpk72	500	1	Standardised	standardised	JJ
cord-012902-efprpk72	500	2	mean	mean	JJ
cord-012902-efprpk72	500	3	differences	difference	NNS
cord-012902-efprpk72	500	4	in	in	IN
cord-012902-efprpk72	500	5	BP	BP	NNP
cord-012902-efprpk72	500	6	and	and	CC
cord-012902-efprpk72	500	7	95	95	CD
cord-012902-efprpk72	500	8	%	%	NN
cord-012902-efprpk72	500	9	C.I.	C.I.	NNP
cord-012902-efprpk72	500	10	were	be	VBD
cord-012902-efprpk72	500	11	pooled	pool	VBN
cord-012902-efprpk72	500	12	using	use	VBG
cord-012902-efprpk72	500	13	a	a	DT
cord-012902-efprpk72	500	14	random	random	JJ
cord-012902-efprpk72	500	15	effect	effect	NN
cord-012902-efprpk72	500	16	model	model	NN
cord-012902-efprpk72	500	17	.	.	.
cord-012902-efprpk72	501	1	Quality	quality	NN
cord-012902-efprpk72	501	2	,	,	,
cord-012902-efprpk72	501	3	sensitivity	sensitivity	NN
cord-012902-efprpk72	501	4	,	,	,
cord-012902-efprpk72	501	5	heterogeneity	heterogeneity	NN
cord-012902-efprpk72	501	6	and	and	CC
cord-012902-efprpk72	501	7	publication	publication	NN
cord-012902-efprpk72	501	8	bias	bias	NN
cord-012902-efprpk72	501	9	were	be	VBD
cord-012902-efprpk72	501	10	assessed	assess	VBN
cord-012902-efprpk72	501	11	.	.	.
cord-012902-efprpk72	502	1	Results	result	NNS
cord-012902-efprpk72	502	2	:	:	:
cord-012902-efprpk72	503	1	Thirty	thirty	CD
cord-012902-efprpk72	503	2	-	-	HYPH
cord-012902-efprpk72	503	3	nine	nine	CD
cord-012902-efprpk72	503	4	studies	study	NNS
cord-012902-efprpk72	503	5	met	meet	VBD
cord-012902-efprpk72	503	6	the	the	DT
cord-012902-efprpk72	503	7	inclusion	inclusion	NN
cord-012902-efprpk72	503	8	criteria	criterion	NNS
cord-012902-efprpk72	503	9	.	.	.
cord-012902-efprpk72	504	1	They	-PRON-	PRP
cord-012902-efprpk72	504	2	included	include	VBD
cord-012902-efprpk72	504	3	8203	8203	CD
cord-012902-efprpk72	504	4	participants	participant	NNS
cord-012902-efprpk72	504	5	(	(	-LRB-
cord-012902-efprpk72	504	6	4333	4333	CD
cord-012902-efprpk72	504	7	in	in	IN
cord-012902-efprpk72	504	8	intervention	intervention	NN
cord-012902-efprpk72	504	9	;	;	:
cord-012902-efprpk72	504	10	3870	3870	CD
cord-012902-efprpk72	504	11	control	control	NN
cord-012902-efprpk72	504	12	groups	group	NNS
cord-012902-efprpk72	504	13	)	)	-RRB-
cord-012902-efprpk72	504	14	.	.	.
cord-012902-efprpk72	505	1	Median	median	JJ
cord-012902-efprpk72	505	2	sample	sample	NN
cord-012902-efprpk72	505	3	size	size	NN
cord-012902-efprpk72	505	4	was	be	VBD
cord-012902-efprpk72	506	1	n	n	NN
cord-012902-efprpk72	506	2	=	=	SYM
cord-012902-efprpk72	506	3	65	65	CD
cord-012902-efprpk72	507	1	(	(	-LRB-
cord-012902-efprpk72	507	2	range	range	NNP
cord-012902-efprpk72	507	3	11	11	CD
cord-012902-efprpk72	507	4	-	-	HYPH
cord-012902-efprpk72	507	5	4717	4717	CD
cord-012902-efprpk72	507	6	)	)	-RRB-
cord-012902-efprpk72	507	7	and	and	CC
cord-012902-efprpk72	507	8	mean	mean	VB
cord-012902-efprpk72	507	9	age	age	NN
cord-012902-efprpk72	507	10	of	of	IN
cord-012902-efprpk72	507	11	the	the	DT
cord-012902-efprpk72	507	12	participants	participant	NNS
cord-012902-efprpk72	507	13	50.5	50.5	CD
cord-012902-efprpk72	507	14	yrs	yr	NNS
cord-012902-efprpk72	507	15	(	(	-LRB-
cord-012902-efprpk72	507	16	range	range	NNP
cord-012902-efprpk72	507	17	25.6	25.6	CD
cord-012902-efprpk72	507	18	-	-	HYPH
cord-012902-efprpk72	507	19	71.0	71.0	CD
cord-012902-efprpk72	507	20	)	)	-RRB-
cord-012902-efprpk72	507	21	.	.	.
cord-012902-efprpk72	508	1	All	all	DT
cord-012902-efprpk72	508	2	were	be	VBD
cord-012902-efprpk72	508	3	controlled	control	VBN
cord-012902-efprpk72	508	4	trials	trial	NNS
cord-012902-efprpk72	508	5	(	(	-LRB-
cord-012902-efprpk72	508	6	duration	duration	NN
cord-012902-efprpk72	508	7	1.4	1.4	CD
cord-012902-efprpk72	508	8	-	-	SYM
cord-012902-efprpk72	508	9	208	208	CD
cord-012902-efprpk72	508	10	weeks	week	NNS
cord-012902-efprpk72	508	11	,	,	,
cord-012902-efprpk72	508	12	median	median	JJ
cord-012902-efprpk72	508	13	12	12	CD
cord-012902-efprpk72	508	14	wks	wk	NNS
cord-012902-efprpk72	508	15	)	)	-RRB-
cord-012902-efprpk72	508	16	.	.	.
cord-012902-efprpk72	509	1	Of	of	IN
cord-012902-efprpk72	509	2	the	the	DT
cord-012902-efprpk72	509	3	39	39	CD
cord-012902-efprpk72	509	4	trials	trial	NNS
cord-012902-efprpk72	509	5	,	,	,
cord-012902-efprpk72	509	6	36	36	CD
cord-012902-efprpk72	509	7	were	be	VBD
cord-012902-efprpk72	509	8	randomised	randomised	JJ
cord-012902-efprpk72	509	9	.	.	.
cord-012902-efprpk72	510	1	Seven	seven	CD
cord-012902-efprpk72	510	2	were	be	VBD
cord-012902-efprpk72	510	3	crossover	crossover	NN
cord-012902-efprpk72	510	4	.	.	.
cord-012902-efprpk72	511	1	Two	two	CD
cord-012902-efprpk72	511	2	were	be	VBD
cord-012902-efprpk72	511	3	singleblinded	singleblinde	VBN
cord-012902-efprpk72	511	4	.	.	.
cord-012902-efprpk72	512	1	Three	three	CD
cord-012902-efprpk72	512	2	had	have	VBD
cord-012902-efprpk72	512	3	controlled	control	VBN
cord-012902-efprpk72	512	4	feeding	feeding	NN
cord-012902-efprpk72	512	5	and	and	CC
cord-012902-efprpk72	512	6	all	all	DT
cord-012902-efprpk72	512	7	were	be	VBD
cord-012902-efprpk72	512	8	in	in	IN
cord-012902-efprpk72	512	9	free	free	JJ
cord-012902-efprpk72	512	10	living	living	NN
cord-012902-efprpk72	512	11	individuals	individual	NNS
cord-012902-efprpk72	512	12	.	.	.
cord-012902-efprpk72	513	1	The	the	DT
cord-012902-efprpk72	513	2	interventions	intervention	NNS
cord-012902-efprpk72	513	3	were	be	VBD
cord-012902-efprpk72	513	4	DASH	dash	NN
cord-012902-efprpk72	513	5	diet	diet	NN
cord-012902-efprpk72	513	6	(	(	-LRB-
cord-012902-efprpk72	513	7	n	n	NN
cord-012902-efprpk72	513	8	=	=	SYM
cord-012902-efprpk72	513	9	11	11	CD
cord-012902-efprpk72	513	10	)	)	-RRB-
cord-012902-efprpk72	513	11	,	,	,
cord-012902-efprpk72	513	12	Mediterranean	Mediterranean	NNP
cord-012902-efprpk72	513	13	diet	diet	NN
cord-012902-efprpk72	513	14	(	(	-LRB-
cord-012902-efprpk72	513	15	MD	MD	NNP
cord-012902-efprpk72	513	16	,	,	,
cord-012902-efprpk72	513	17	n	n	NN
cord-012902-efprpk72	513	18	=	=	SYM
cord-012902-efprpk72	513	19	8)	8)	NNP
cord-012902-efprpk72	513	20	,	,	,
cord-012902-efprpk72	513	21	vegan	vegan	JJ
cord-012902-efprpk72	513	22	diet	diet	NN
cord-012902-efprpk72	513	23	(	(	-LRB-
cord-012902-efprpk72	513	24	VD	VD	NNP
cord-012902-efprpk72	513	25	,	,	,
cord-012902-efprpk72	513	26	n	n	NN
cord-012902-efprpk72	513	27	=	=	SYM
cord-012902-efprpk72	513	28	8)	8)	NNP
cord-012902-efprpk72	513	29	,	,	,
cord-012902-efprpk72	513	30	lacto	lacto	NNP
cord-012902-efprpk72	513	31	-	-	HYPH
cord-012902-efprpk72	513	32	ovo	ovo	NNP
cord-012902-efprpk72	513	33	vegetarian	vegetarian	JJ
cord-012902-efprpk72	513	34	diet	diet	NN
cord-012902-efprpk72	513	35	(	(	-LRB-
cord-012902-efprpk72	513	36	LOVD	LOVD	NNP
cord-012902-efprpk72	513	37	,	,	,
cord-012902-efprpk72	513	38	n	n	NN
cord-012902-efprpk72	513	39	=	=	SYM
cord-012902-efprpk72	513	40	5	5	CD
cord-012902-efprpk72	513	41	)	)	-RRB-
cord-012902-efprpk72	513	42	,	,	,
cord-012902-efprpk72	513	43	healthy	healthy	JJ
cord-012902-efprpk72	513	44	Nordic	nordic	JJ
cord-012902-efprpk72	513	45	diet	diet	NN
cord-012902-efprpk72	513	46	(	(	-LRB-
cord-012902-efprpk72	513	47	ND	ND	NNP
cord-012902-efprpk72	513	48	,	,	,
cord-012902-efprpk72	513	49	n	n	NN
cord-012902-efprpk72	513	50	=	=	SYM
cord-012902-efprpk72	513	51	3	3	CD
cord-012902-efprpk72	513	52	)	)	-RRB-
cord-012902-efprpk72	513	53	,	,	,
cord-012902-efprpk72	513	54	high	high	JJ
cord-012902-efprpk72	513	55	fibre	fibre	NN
cord-012902-efprpk72	513	56	diet	diet	NN
cord-012902-efprpk72	513	57	(	(	-LRB-
cord-012902-efprpk72	513	58	HFD	HFD	NNP
cord-012902-efprpk72	513	59	,	,	,
cord-012902-efprpk72	513	60	n	n	NN
cord-012902-efprpk72	513	61	=	=	SYM
cord-012902-efprpk72	513	62	3	3	CD
cord-012902-efprpk72	513	63	)	)	-RRB-
cord-012902-efprpk72	513	64	,	,	,
cord-012902-efprpk72	513	65	and	and	CC
cord-012902-efprpk72	513	66	high	high	JJ
cord-012902-efprpk72	513	67	fruit	fruit	NN
cord-012902-efprpk72	513	68	and	and	CC
cord-012902-efprpk72	513	69	vegetables	vegetable	VBZ
cord-012902-efprpk72	513	70	diet	diet	NN
cord-012902-efprpk72	513	71	(	(	-LRB-
cord-012902-efprpk72	513	72	FVD	FVD	NNP
cord-012902-efprpk72	513	73	,	,	,
cord-012902-efprpk72	513	74	n	n	NN
cord-012902-efprpk72	513	75	=	=	SYM
cord-012902-efprpk72	513	76	2	2	CD
cord-012902-efprpk72	513	77	)	)	-RRB-
cord-012902-efprpk72	513	78	.	.	.
cord-012902-efprpk72	514	1	In	in	IN
cord-012902-efprpk72	514	2	the	the	DT
cord-012902-efprpk72	514	3	pooled	pool	VBN
cord-012902-efprpk72	514	4	analysis	analysis	NN
cord-012902-efprpk72	514	5	,	,	,
cord-012902-efprpk72	514	6	PBDs	pbd	NNS
cord-012902-efprpk72	514	7	were	be	VBD
cord-012902-efprpk72	514	8	associated	associate	VBN
cord-012902-efprpk72	514	9	with	with	IN
cord-012902-efprpk72	514	10	lower	low	JJR
cord-012902-efprpk72	514	11	systolic	systolic	JJ
cord-012902-efprpk72	514	12	BP	BP	NNP
cord-012902-efprpk72	514	13	(	(	-LRB-
cord-012902-efprpk72	514	14	DASH	dash	NN
cord-012902-efprpk72	515	1	There	there	EX
cord-012902-efprpk72	515	2	was	be	VBD
cord-012902-efprpk72	515	3	no	no	DT
cord-012902-efprpk72	515	4	evidence	evidence	NN
cord-012902-efprpk72	515	5	of	of	IN
cord-012902-efprpk72	515	6	publication	publication	NN
cord-012902-efprpk72	515	7	bias	bias	NN
cord-012902-efprpk72	515	8	and	and	CC
cord-012902-efprpk72	515	9	some	some	DT
cord-012902-efprpk72	515	10	heterogeneity	heterogeneity	NN
cord-012902-efprpk72	515	11	was	be	VBD
cord-012902-efprpk72	515	12	detected	detect	VBN
cord-012902-efprpk72	515	13	.	.	.
cord-012902-efprpk72	516	1	Conclusions	conclusion	NNS
cord-012902-efprpk72	516	2	:	:	:
cord-012902-efprpk72	516	3	PBDs	pbd	NNS
cord-012902-efprpk72	516	4	with	with	IN
cord-012902-efprpk72	516	5	limited	limited	JJ
cord-012902-efprpk72	516	6	or	or	CC
cord-012902-efprpk72	516	7	no	no	DT
cord-012902-efprpk72	516	8	animal	animal	NN
cord-012902-efprpk72	516	9	products	product	NNS
cord-012902-efprpk72	516	10	lower	lower	VBP
cord-012902-efprpk72	516	11	both	both	CC
cord-012902-efprpk72	516	12	systolic	systolic	JJ
cord-012902-efprpk72	516	13	and	and	CC
cord-012902-efprpk72	516	14	diastolic	diastolic	JJ
cord-012902-efprpk72	516	15	BP	BP	NNP
cord-012902-efprpk72	516	16	,	,	,
cord-012902-efprpk72	516	17	across	across	IN
cord-012902-efprpk72	516	18	sex	sex	NN
cord-012902-efprpk72	516	19	,	,	,
cord-012902-efprpk72	516	20	age	age	NN
cord-012902-efprpk72	516	21	and	and	CC
cord-012902-efprpk72	516	22	body	body	NN
cord-012902-efprpk72	516	23	mass	mass	NN
cord-012902-efprpk72	516	24	index	index	NN
cord-012902-efprpk72	516	25	.	.	.
cord-012902-efprpk72	517	1	Disclosures	disclosure	NNS
cord-012902-efprpk72	517	2	:	:	:
cord-012902-efprpk72	517	3	None	none	NN
cord-012902-efprpk72	517	4	.	.	.
cord-012902-efprpk72	518	1	Introduction	introduction	NN
cord-012902-efprpk72	518	2	:	:	:
cord-012902-efprpk72	519	1	Hypertension	hypertension	NN
cord-012902-efprpk72	519	2	is	be	VBZ
cord-012902-efprpk72	519	3	one	one	CD
cord-012902-efprpk72	519	4	of	of	IN
cord-012902-efprpk72	519	5	the	the	DT
cord-012902-efprpk72	519	6	most	most	RBS
cord-012902-efprpk72	519	7	common	common	JJ
cord-012902-efprpk72	519	8	public	public	JJ
cord-012902-efprpk72	519	9	health	health	NN
cord-012902-efprpk72	519	10	problems	problem	NNS
cord-012902-efprpk72	519	11	and	and	CC
cord-012902-efprpk72	519	12	the	the	DT
cord-012902-efprpk72	519	13	morbidity	morbidity	NN
cord-012902-efprpk72	519	14	increases	increase	VBZ
cord-012902-efprpk72	519	15	with	with	IN
cord-012902-efprpk72	519	16	age	age	NN
cord-012902-efprpk72	519	17	.	.	.
cord-012902-efprpk72	520	1	The	the	DT
cord-012902-efprpk72	520	2	main	main	JJ
cord-012902-efprpk72	520	3	aim	aim	NN
cord-012902-efprpk72	520	4	of	of	IN
cord-012902-efprpk72	520	5	treatment	treatment	NN
cord-012902-efprpk72	520	6	with	with	IN
cord-012902-efprpk72	520	7	hypotension	hypotension	NN
cord-012902-efprpk72	520	8	is	be	VBZ
cord-012902-efprpk72	520	9	to	to	TO
cord-012902-efprpk72	520	10	reduce	reduce	VB
cord-012902-efprpk72	520	11	the	the	DT
cord-012902-efprpk72	520	12	long	long	JJ
cord-012902-efprpk72	520	13	-	-	HYPH
cord-012902-efprpk72	520	14	term	term	NN
cord-012902-efprpk72	520	15	total	total	JJ
cord-012902-efprpk72	520	16	risk	risk	NN
cord-012902-efprpk72	520	17	of	of	IN
cord-012902-efprpk72	520	18	cardiovascular	cardiovascular	JJ
cord-012902-efprpk72	520	19	diseases	disease	NNS
cord-012902-efprpk72	520	20	and	and	CC
cord-012902-efprpk72	520	21	improve	improve	VB
cord-012902-efprpk72	520	22	quality	quality	NN
cord-012902-efprpk72	520	23	of	of	IN
cord-012902-efprpk72	520	24	life	life	NN
cord-012902-efprpk72	520	25	(	(	-LRB-
cord-012902-efprpk72	520	26	QoL	qol	NN
cord-012902-efprpk72	520	27	)	)	-RRB-
cord-012902-efprpk72	520	28	.	.	.
cord-012902-efprpk72	521	1	The	the	DT
cord-012902-efprpk72	521	2	components	component	NNS
cord-012902-efprpk72	521	3	of	of	IN
cord-012902-efprpk72	521	4	QoL	qol	NN
cord-012902-efprpk72	521	5	in	in	IN
cord-012902-efprpk72	521	6	old	old	JJ
cord-012902-efprpk72	521	7	age	age	NN
cord-012902-efprpk72	521	8	include	include	VBP
cord-012902-efprpk72	521	9	subjective	subjective	JJ
cord-012902-efprpk72	521	10	health	health	NN
cord-012902-efprpk72	521	11	assessment	assessment	NN
cord-012902-efprpk72	521	12	covering	cover	VBG
cord-012902-efprpk72	521	13	physical	physical	JJ
cord-012902-efprpk72	521	14	,	,	,
cord-012902-efprpk72	521	15	social	social	JJ
cord-012902-efprpk72	521	16	,	,	,
cord-012902-efprpk72	521	17	emotional	emotional	JJ
cord-012902-efprpk72	521	18	and	and	CC
cord-012902-efprpk72	521	19	health	health	NN
cord-012902-efprpk72	521	20	condition	condition	NN
cord-012902-efprpk72	521	21	[	[	-LRB-
cord-012902-efprpk72	521	22	1	1	CD
cord-012902-efprpk72	521	23	]	]	-RRB-
cord-012902-efprpk72	521	24	.	.	.
cord-012902-efprpk72	522	1	The	the	DT
cord-012902-efprpk72	522	2	aim	aim	NN
cord-012902-efprpk72	522	3	of	of	IN
cord-012902-efprpk72	522	4	the	the	DT
cord-012902-efprpk72	522	5	study	study	NN
cord-012902-efprpk72	522	6	was	be	VBD
cord-012902-efprpk72	522	7	to	to	TO
cord-012902-efprpk72	522	8	evaluate	evaluate	VB
cord-012902-efprpk72	522	9	the	the	DT
cord-012902-efprpk72	522	10	quality	quality	NN
cord-012902-efprpk72	522	11	of	of	IN
cord-012902-efprpk72	522	12	life	life	NN
cord-012902-efprpk72	522	13	of	of	IN
cord-012902-efprpk72	522	14	patients	patient	NNS
cord-012902-efprpk72	522	15	with	with	IN
cord-012902-efprpk72	522	16	hypertension	hypertension	NN
cord-012902-efprpk72	522	17	in	in	IN
cord-012902-efprpk72	522	18	the	the	DT
cord-012902-efprpk72	522	19	elderly	elderly	JJ
cord-012902-efprpk72	522	20	and	and	CC
cord-012902-efprpk72	522	21	the	the	DT
cord-012902-efprpk72	522	22	influence	influence	NN
cord-012902-efprpk72	522	23	of	of	IN
cord-012902-efprpk72	522	24	selected	select	VBN
cord-012902-efprpk72	522	25	sociodemographic	sociodemographic	JJ
cord-012902-efprpk72	522	26	factors	factor	NNS
cord-012902-efprpk72	522	27	and	and	CC
cord-012902-efprpk72	522	28	clinical	clinical	JJ
cord-012902-efprpk72	522	29	variables	variable	NNS
cord-012902-efprpk72	522	30	on	on	IN
cord-012902-efprpk72	522	31	its	-PRON-	PRP$
cord-012902-efprpk72	522	32	evaluation	evaluation	NN
cord-012902-efprpk72	522	33	.	.	.
cord-012902-efprpk72	523	1	Methods	method	NNS
cord-012902-efprpk72	523	2	:	:	:
cord-012902-efprpk72	523	3	102	102	CD
cord-012902-efprpk72	523	4	patients	patient	NNS
cord-012902-efprpk72	523	5	were	be	VBD
cord-012902-efprpk72	523	6	examined	examine	VBN
cord-012902-efprpk72	523	7	,	,	,
cord-012902-efprpk72	523	8	including	include	VBG
cord-012902-efprpk72	523	9	44	44	CD
cord-012902-efprpk72	523	10	men	man	NNS
cord-012902-efprpk72	523	11	and	and	CC
cord-012902-efprpk72	523	12	58	58	CD
cord-012902-efprpk72	523	13	women	woman	NNS
cord-012902-efprpk72	523	14	.	.	.
cord-012902-efprpk72	524	1	The	the	DT
cord-012902-efprpk72	524	2	average	average	JJ
cord-012902-efprpk72	524	3	age	age	NN
cord-012902-efprpk72	524	4	of	of	IN
cord-012902-efprpk72	524	5	respondents	respondent	NNS
cord-012902-efprpk72	524	6	was	be	VBD
cord-012902-efprpk72	524	7	69.71	69.71	CD
cord-012902-efprpk72	524	8	(	(	-LRB-
cord-012902-efprpk72	524	9	SD	sd	NN
cord-012902-efprpk72	524	10	=	=	SYM
cord-012902-efprpk72	524	11	2.92	2.92	CD
cord-012902-efprpk72	524	12	)	)	-RRB-
cord-012902-efprpk72	524	13	.	.	.
cord-012902-efprpk72	525	1	The	the	DT
cord-012902-efprpk72	525	2	WHOQoL	WHOQoL	NNP
cord-012902-efprpk72	525	3	-	-	HYPH
cord-012902-efprpk72	525	4	BREF	BREF	NNP
cord-012902-efprpk72	525	5	standardised	standardised	JJ
cord-012902-efprpk72	525	6	questionnaire	questionnaire	NN
cord-012902-efprpk72	525	7	was	be	VBD
cord-012902-efprpk72	525	8	used	use	VBN
cord-012902-efprpk72	525	9	to	to	TO
cord-012902-efprpk72	525	10	assess	assess	VB
cord-012902-efprpk72	525	11	quality	quality	NN
cord-012902-efprpk72	525	12	of	of	IN
cord-012902-efprpk72	525	13	life	life	NN
cord-012902-efprpk72	525	14	and	and	CC
cord-012902-efprpk72	525	15	medical	medical	JJ
cord-012902-efprpk72	525	16	records	record	NNS
cord-012902-efprpk72	525	17	were	be	VBD
cord-012902-efprpk72	525	18	analysed	analyse	VBN
cord-012902-efprpk72	525	19	.	.	.
cord-012902-efprpk72	526	1	Results	result	NNS
cord-012902-efprpk72	526	2	:	:	:
cord-012902-efprpk72	527	1	The	the	DT
cord-012902-efprpk72	527	2	mean	mean	JJ
cord-012902-efprpk72	527	3	score	score	NN
cord-012902-efprpk72	527	4	for	for	IN
cord-012902-efprpk72	527	5	quality	quality	NN
cord-012902-efprpk72	527	6	of	of	IN
cord-012902-efprpk72	527	7	life	life	NN
cord-012902-efprpk72	527	8	was	be	VBD
cord-012902-efprpk72	527	9	3.28	3.28	CD
cord-012902-efprpk72	527	10	points	point	NNS
cord-012902-efprpk72	527	11	(	(	-LRB-
cord-012902-efprpk72	527	12	SD	sd	NN
cord-012902-efprpk72	527	13	=	=	SYM
cord-012902-efprpk72	527	14	0.69	0.69	CD
cord-012902-efprpk72	527	15	)	)	-RRB-
cord-012902-efprpk72	527	16	,	,	,
cord-012902-efprpk72	527	17	while	while	IN
cord-012902-efprpk72	527	18	the	the	DT
cord-012902-efprpk72	527	19	mean	mean	JJ
cord-012902-efprpk72	527	20	score	score	NN
cord-012902-efprpk72	527	21	for	for	IN
cord-012902-efprpk72	527	22	own	own	JJ
cord-012902-efprpk72	527	23	health	health	NN
cord-012902-efprpk72	527	24	was	be	VBD
cord-012902-efprpk72	527	25	2.61	2.61	CD
cord-012902-efprpk72	527	26	points	point	NNS
cord-012902-efprpk72	527	27	(	(	-LRB-
cord-012902-efprpk72	527	28	SD	sd	NN
cord-012902-efprpk72	527	29	=	=	SYM
cord-012902-efprpk72	527	30	0.73).Patients	0.73).patient	NNS
cord-012902-efprpk72	527	31	with	with	IN
cord-012902-efprpk72	527	32	hypertension	hypertension	NN
cord-012902-efprpk72	527	33	rated	rate	VBD
cord-012902-efprpk72	527	34	their	-PRON-	PRP$
cord-012902-efprpk72	527	35	QoL	qol	NN
cord-012902-efprpk72	527	36	best	best	RB
cord-012902-efprpk72	527	37	in	in	IN
cord-012902-efprpk72	527	38	the	the	DT
cord-012902-efprpk72	527	39	psychological	psychological	JJ
cord-012902-efprpk72	527	40	field	field	NN
cord-012902-efprpk72	527	41	(	(	-LRB-
cord-012902-efprpk72	527	42	mean	mean	VB
cord-012902-efprpk72	527	43	2.4	2.4	CD
cord-012902-efprpk72	527	44	;	;	:
cord-012902-efprpk72	527	45	SD	sd	NN
cord-012902-efprpk72	527	46	=	=	SYM
cord-012902-efprpk72	527	47	0.64	0.64	CD
cord-012902-efprpk72	527	48	)	)	-RRB-
cord-012902-efprpk72	527	49	and	and	CC
cord-012902-efprpk72	527	50	worst	bad	JJS
cord-012902-efprpk72	527	51	in	in	IN
cord-012902-efprpk72	527	52	the	the	DT
cord-012902-efprpk72	527	53	physical	physical	JJ
cord-012902-efprpk72	527	54	field	field	NN
cord-012902-efprpk72	527	55	(	(	-LRB-
cord-012902-efprpk72	527	56	mean	mean	VB
cord-012902-efprpk72	527	57	3.4	3.4	CD
cord-012902-efprpk72	527	58	;	;	:
cord-012902-efprpk72	527	59	SD	sd	NN
cord-012902-efprpk72	527	60	=	=	SYM
cord-012902-efprpk72	527	61	1.19).Men	1.19).men	CD
cord-012902-efprpk72	527	62	showed	show	VBD
cord-012902-efprpk72	527	63	significantly	significantly	RB
cord-012902-efprpk72	527	64	better	well	JJR
cord-012902-efprpk72	527	65	quality	quality	NN
cord-012902-efprpk72	527	66	of	of	IN
cord-012902-efprpk72	527	67	life	life	NN
cord-012902-efprpk72	527	68	than	than	IN
cord-012902-efprpk72	527	69	women	woman	NNS
cord-012902-efprpk72	527	70	(	(	-LRB-
cord-012902-efprpk72	527	71	p	p	NN
cord-012902-efprpk72	527	72	<	<	XX
cord-012902-efprpk72	527	73	0.005	0.005	CD
cord-012902-efprpk72	527	74	)	)	-RRB-
cord-012902-efprpk72	527	75	in	in	IN
cord-012902-efprpk72	527	76	such	such	JJ
cord-012902-efprpk72	527	77	areas	area	NNS
cord-012902-efprpk72	527	78	as	as	IN
cord-012902-efprpk72	527	79	:	:	:
cord-012902-efprpk72	527	80	perception	perception	NN
cord-012902-efprpk72	527	81	of	of	IN
cord-012902-efprpk72	527	82	quality	quality	NN
cord-012902-efprpk72	527	83	of	of	IN
cord-012902-efprpk72	527	84	life	life	NN
cord-012902-efprpk72	527	85	(	(	-LRB-
cord-012902-efprpk72	527	86	mean	mean	VB
cord-012902-efprpk72	527	87	3.48	3.48	CD
cord-012902-efprpk72	527	88	;	;	:
cord-012902-efprpk72	527	89	SD	sd	NN
cord-012902-efprpk72	527	90	=	=	SYM
cord-012902-efprpk72	527	91	0.7	0.7	CD
cord-012902-efprpk72	528	1	vs	vs	IN
cord-012902-efprpk72	528	2	mean	mean	JJ
cord-012902-efprpk72	528	3	3.14	3.14	CD
cord-012902-efprpk72	528	4	;	;	:
cord-012902-efprpk72	528	5	SD	sd	NN
cord-012902-efprpk72	528	6	=	=	SYM
cord-012902-efprpk72	528	7	0.66	0.66	CD
cord-012902-efprpk72	528	8	)	)	-RRB-
cord-012902-efprpk72	528	9	,	,	,
cord-012902-efprpk72	528	10	physical	physical	JJ
cord-012902-efprpk72	528	11	domain	domain	NN
cord-012902-efprpk72	528	12	(	(	-LRB-
cord-012902-efprpk72	528	13	mean	mean	VB
cord-012902-efprpk72	528	14	12.68	12.68	CD
cord-012902-efprpk72	528	15	;	;	:
cord-012902-efprpk72	528	16	SD	sd	NN
cord-012902-efprpk72	528	17	=	=	SYM
cord-012902-efprpk72	528	18	2.04	2.04	CD
cord-012902-efprpk72	528	19	vs	vs	IN
cord-012902-efprpk72	528	20	mean	mean	JJ
cord-012902-efprpk72	528	21	11.36	11.36	CD
cord-012902-efprpk72	528	22	;	;	:
cord-012902-efprpk72	528	23	SD	sd	NN
cord-012902-efprpk72	528	24	=	=	SYM
cord-012902-efprpk72	528	25	2.36	2.36	CD
cord-012902-efprpk72	528	26	)	)	-RRB-
cord-012902-efprpk72	528	27	and	and	CC
cord-012902-efprpk72	528	28	environmental	environmental	JJ
cord-012902-efprpk72	528	29	domain	domain	NN
cord-012902-efprpk72	528	30	(	(	-LRB-
cord-012902-efprpk72	528	31	mean	mean	VB
cord-012902-efprpk72	528	32	14.82	14.82	CD
cord-012902-efprpk72	528	33	;	;	:
cord-012902-efprpk72	528	34	SD	sd	NN
cord-012902-efprpk72	528	35	=	=	SYM
cord-012902-efprpk72	528	36	1.99	1.99	CD
cord-012902-efprpk72	529	1	vs	vs	IN
cord-012902-efprpk72	529	2	mean	mean	VB
cord-012902-efprpk72	529	3	13.5	13.5	CD
cord-012902-efprpk72	529	4	;	;	:
cord-012902-efprpk72	529	5	SD	sd	NN
cord-012902-efprpk72	529	6	=	=	SYM
cord-012902-efprpk72	529	7	2.22	2.22	CD
cord-012902-efprpk72	529	8	)	)	-RRB-
cord-012902-efprpk72	529	9	.	.	.
cord-012902-efprpk72	530	1	Age	age	NN
cord-012902-efprpk72	530	2	correlated	correlate	VBD
cord-012902-efprpk72	530	3	significantly	significantly	RB
cord-012902-efprpk72	530	4	and	and	CC
cord-012902-efprpk72	530	5	negatively	negatively	RB
cord-012902-efprpk72	530	6	with	with	IN
cord-012902-efprpk72	530	7	the	the	DT
cord-012902-efprpk72	530	8	quality	quality	NN
cord-012902-efprpk72	530	9	of	of	IN
cord-012902-efprpk72	530	10	life	life	NN
cord-012902-efprpk72	530	11	in	in	IN
cord-012902-efprpk72	530	12	each	each	DT
cord-012902-efprpk72	530	13	field	field	NN
cord-012902-efprpk72	530	14	(	(	-LRB-
cord-012902-efprpk72	530	15	p	p	XX
cord-012902-efprpk72	530	16	<	<	XX
cord-012902-efprpk72	530	17	0.05).Persons	0.05).persons	CD
cord-012902-efprpk72	530	18	with	with	IN
cord-012902-efprpk72	530	19	higher	high	JJR
cord-012902-efprpk72	530	20	education	education	NN
cord-012902-efprpk72	530	21	and	and	CC
cord-012902-efprpk72	530	22	married	married	JJ
cord-012902-efprpk72	530	23	had	have	VBD
cord-012902-efprpk72	530	24	higher	high	JJR
cord-012902-efprpk72	530	25	QoL	qol	NN
cord-012902-efprpk72	530	26	rating	rating	NN
cord-012902-efprpk72	530	27	(	(	-LRB-
cord-012902-efprpk72	530	28	p	p	NN
cord-012902-efprpk72	530	29	<	<	XX
cord-012902-efprpk72	530	30	0.05	0.05	CD
cord-012902-efprpk72	530	31	)	)	-RRB-
cord-012902-efprpk72	530	32	.	.	.
cord-012902-efprpk72	531	1	Conclusions	conclusion	NNS
cord-012902-efprpk72	531	2	:	:	:
cord-012902-efprpk72	532	1	Patients	patient	NNS
cord-012902-efprpk72	532	2	with	with	IN
cord-012902-efprpk72	532	3	hypertension	hypertension	NN
cord-012902-efprpk72	532	4	have	have	VBP
cord-012902-efprpk72	532	5	a	a	DT
cord-012902-efprpk72	532	6	reduced	reduce	VBN
cord-012902-efprpk72	532	7	quality	quality	NN
cord-012902-efprpk72	532	8	of	of	IN
cord-012902-efprpk72	532	9	life	life	NN
cord-012902-efprpk72	532	10	,	,	,
cord-012902-efprpk72	532	11	especially	especially	RB
cord-012902-efprpk72	532	12	with	with	IN
cord-012902-efprpk72	532	13	regard	regard	NN
cord-012902-efprpk72	532	14	to	to	IN
cord-012902-efprpk72	532	15	physical	physical	JJ
cord-012902-efprpk72	532	16	functioning	functioning	NN
cord-012902-efprpk72	532	17	.	.	.
cord-012902-efprpk72	533	1	Higher	high	JJR
cord-012902-efprpk72	533	2	QoL	qol	NN
cord-012902-efprpk72	533	3	scores	score	NNS
cord-012902-efprpk72	533	4	were	be	VBD
cord-012902-efprpk72	533	5	observed	observe	VBN
cord-012902-efprpk72	533	6	in	in	IN
cord-012902-efprpk72	533	7	the	the	DT
cord-012902-efprpk72	533	8	group	group	NN
cord-012902-efprpk72	533	9	of	of	IN
cord-012902-efprpk72	533	10	men	man	NNS
cord-012902-efprpk72	533	11	,	,	,
cord-012902-efprpk72	533	12	persons	person	NNS
cord-012902-efprpk72	533	13	with	with	IN
cord-012902-efprpk72	533	14	higher	high	JJR
cord-012902-efprpk72	533	15	education	education	NN
cord-012902-efprpk72	533	16	and	and	CC
cord-012902-efprpk72	533	17	married	married	JJ
cord-012902-efprpk72	533	18	.	.	.
cord-012902-efprpk72	534	1	Moreover	moreover	RB
cord-012902-efprpk72	534	2	,	,	,
cord-012902-efprpk72	534	3	the	the	DT
cord-012902-efprpk72	534	4	older	old	JJR
cord-012902-efprpk72	534	5	the	the	DT
cord-012902-efprpk72	534	6	age	age	NN
cord-012902-efprpk72	534	7	of	of	IN
cord-012902-efprpk72	534	8	the	the	DT
cord-012902-efprpk72	534	9	respondents	respondent	NNS
cord-012902-efprpk72	534	10	,	,	,
cord-012902-efprpk72	534	11	the	the	DT
cord-012902-efprpk72	534	12	worse	bad	JJR
cord-012902-efprpk72	534	13	the	the	DT
cord-012902-efprpk72	534	14	quality	quality	NN
cord-012902-efprpk72	534	15	of	of	IN
cord-012902-efprpk72	534	16	life	life	NN
cord-012902-efprpk72	534	17	in	in	IN
cord-012902-efprpk72	534	18	all	all	DT
cord-012902-efprpk72	534	19	areas	area	NNS
cord-012902-efprpk72	534	20	of	of	IN
cord-012902-efprpk72	534	21	QoL.	QoL.	NNP
cord-012902-efprpk72	534	22	Disclosures	disclosure	NNS
cord-012902-efprpk72	534	23	:	:	:
cord-012902-efprpk72	534	24	None	none	NN
cord-012902-efprpk72	534	25	.	.	.
cord-012902-efprpk72	534	26	[	[	-LRB-
cord-012902-efprpk72	534	27	1	1	CD
cord-012902-efprpk72	534	28	,	,	,
cord-012902-efprpk72	534	29	2	2	CD
cord-012902-efprpk72	534	30	]	]	-RRB-
cord-012902-efprpk72	534	31	;	;	:
cord-012902-efprpk72	534	32	however	however	RB
cord-012902-efprpk72	534	33	,	,	,
cord-012902-efprpk72	534	34	its	-PRON-	PRP$
cord-012902-efprpk72	534	35	effect	effect	NN
cord-012902-efprpk72	534	36	on	on	IN
cord-012902-efprpk72	534	37	atherogenesis	atherogenesis	NNP
cord-012902-efprpk72	534	38	has	have	VBZ
cord-012902-efprpk72	534	39	not	not	RB
cord-012902-efprpk72	534	40	been	be	VBN
cord-012902-efprpk72	534	41	studied	study	VBN
cord-012902-efprpk72	534	42	.	.	.
cord-012902-efprpk72	535	1	We	-PRON-	PRP
cord-012902-efprpk72	535	2	tested	test	VBD
cord-012902-efprpk72	535	3	if	if	IN
cord-012902-efprpk72	535	4	long	long	JJ
cord-012902-efprpk72	535	5	-	-	HYPH
cord-012902-efprpk72	535	6	term	term	NN
cord-012902-efprpk72	535	7	intervention	intervention	NN
cord-012902-efprpk72	535	8	with	with	IN
cord-012902-efprpk72	535	9	dietary	dietary	JJ
cord-012902-efprpk72	535	10	nitrate	nitrate	NN
cord-012902-efprpk72	535	11	(	(	-LRB-
cord-012902-efprpk72	535	12	NO3-	NO3-	NNP
cord-012902-efprpk72	535	13	)	)	-RRB-
cord-012902-efprpk72	535	14	and	and	CC
cord-012902-efprpk72	535	15	spironolactone	spironolactone	NN
cord-012902-efprpk72	535	16	could	could	MD
cord-012902-efprpk72	535	17	affect	affect	VB
cord-012902-efprpk72	535	18	carotid	carotid	JJ
cord-012902-efprpk72	535	19	structure	structure	NN
cord-012902-efprpk72	535	20	and	and	CC
cord-012902-efprpk72	535	21	stiffness	stiffness	NN
cord-012902-efprpk72	535	22	compared	compare	VBN
cord-012902-efprpk72	535	23	to	to	IN
cord-012902-efprpk72	535	24	placebo	placebo	NN
cord-012902-efprpk72	535	25	/	/	SYM
cord-012902-efprpk72	535	26	doxazosin	doxazosin	NN
cord-012902-efprpk72	535	27	,	,	,
cord-012902-efprpk72	535	28	used	use	VBN
cord-012902-efprpk72	535	29	as	as	IN
cord-012902-efprpk72	535	30	control	control	NN
cord-012902-efprpk72	535	31	for	for	IN
cord-012902-efprpk72	535	32	blood	blood	NN
cord-012902-efprpk72	535	33	pressure	pressure	NN
cord-012902-efprpk72	535	34	(	(	-LRB-
cord-012902-efprpk72	535	35	BP	BP	NNP
cord-012902-efprpk72	535	36	)	)	-RRB-
cord-012902-efprpk72	535	37	[	[	-LRB-
cord-012902-efprpk72	535	38	3	3	CD
cord-012902-efprpk72	535	39	,	,	,
cord-012902-efprpk72	535	40	4	4	CD
cord-012902-efprpk72	535	41	]	]	-RRB-
cord-012902-efprpk72	535	42	.	.	.
cord-012902-efprpk72	536	1	Methods	method	NNS
cord-012902-efprpk72	536	2	:	:	:
cord-012902-efprpk72	536	3	Participants	participant	NNS
cord-012902-efprpk72	536	4	in	in	IN
cord-012902-efprpk72	536	5	our	-PRON-	PRP$
cord-012902-efprpk72	536	6	double	double	JJ
cord-012902-efprpk72	536	7	-	-	HYPH
cord-012902-efprpk72	536	8	blind	blind	JJ
cord-012902-efprpk72	536	9	,	,	,
cord-012902-efprpk72	536	10	randomisedcontrolled	randomisedcontrolled	JJ
cord-012902-efprpk72	536	11	,	,	,
cord-012902-efprpk72	536	12	factorial	factorial	JJ
cord-012902-efprpk72	536	13	VaSera	VaSera	NNP
cord-012902-efprpk72	536	14	trial	trial	NN
cord-012902-efprpk72	536	15	,	,	,
cord-012902-efprpk72	536	16	were	be	VBD
cord-012902-efprpk72	536	17	randomised	randomised	JJ
cord-012902-efprpk72	536	18	to	to	IN
cord-012902-efprpk72	536	19	spironolactone	spironolactone	NN
cord-012902-efprpk72	536	20	or	or	CC
cord-012902-efprpk72	536	21	doxazosin	doxazosin	NNP
cord-012902-efprpk72	536	22	and	and	CC
cord-012902-efprpk72	536	23	NO3-as	no3-as	CC
cord-012902-efprpk72	536	24	active	active	JJ
cord-012902-efprpk72	536	25	nitratecontaining	nitratecontaine	VBG
cord-012902-efprpk72	536	26	beetroot	beetroot	NN
cord-012902-efprpk72	536	27	juice	juice	NN
cord-012902-efprpk72	536	28	or	or	CC
cord-012902-efprpk72	536	29	placebo	placebo	NN
cord-012902-efprpk72	536	30	nitrate	nitrate	NN
cord-012902-efprpk72	536	31	-	-	HYPH
cord-012902-efprpk72	536	32	depleted	deplete	VBN
cord-012902-efprpk72	536	33	juice	juice	NN
cord-012902-efprpk72	536	34	.	.	.
cord-012902-efprpk72	537	1	Vascular	vascular	JJ
cord-012902-efprpk72	537	2	ultrasound	ultrasound	NN
cord-012902-efprpk72	537	3	for	for	IN
cord-012902-efprpk72	537	4	carotid	carotid	JJ
cord-012902-efprpk72	537	5	diameter	diameter	NN
cord-012902-efprpk72	537	6	(	(	-LRB-
cord-012902-efprpk72	537	7	CD	CD	NNP
cord-012902-efprpk72	537	8	,	,	,
cord-012902-efprpk72	537	9	mm	mm	NNP
cord-012902-efprpk72	537	10	)	)	-RRB-
cord-012902-efprpk72	537	11	and	and	CC
cord-012902-efprpk72	537	12	intima	intima	NN
cord-012902-efprpk72	537	13	-	-	HYPH
cord-012902-efprpk72	537	14	media	medium	NNS
cord-012902-efprpk72	537	15	thickness	thickness	NN
cord-012902-efprpk72	537	16	(	(	-LRB-
cord-012902-efprpk72	537	17	IMT	IMT	NNP
cord-012902-efprpk72	537	18	,	,	,
cord-012902-efprpk72	537	19	mm	mm	NNP
cord-012902-efprpk72	537	20	)	)	-RRB-
cord-012902-efprpk72	537	21	was	be	VBD
cord-012902-efprpk72	537	22	performed	perform	VBN
cord-012902-efprpk72	537	23	at	at	IN
cord-012902-efprpk72	537	24	baseline	baseline	NN
cord-012902-efprpk72	537	25	and	and	CC
cord-012902-efprpk72	537	26	repeated	repeat	VBD
cord-012902-efprpk72	537	27	at	at	IN
cord-012902-efprpk72	537	28	3-and	3-and	CD
cord-012902-efprpk72	537	29	6-months	6-months	CD
cord-012902-efprpk72	537	30	follow	follow	NN
cord-012902-efprpk72	537	31	-	-	HYPH
cord-012902-efprpk72	537	32	up	up	NN
cord-012902-efprpk72	537	33	.	.	.
cord-012902-efprpk72	538	1	Carotid	carotid	JJ
cord-012902-efprpk72	538	2	local	local	JJ
cord-012902-efprpk72	538	3	stiffness	stiffness	NN
cord-012902-efprpk72	538	4	(	(	-LRB-
cord-012902-efprpk72	538	5	CS	CS	NNP
cord-012902-efprpk72	538	6	,	,	,
cord-012902-efprpk72	538	7	m	m	NNP
cord-012902-efprpk72	538	8	/	/	SYM
cord-012902-efprpk72	538	9	s	s	NNP
cord-012902-efprpk72	538	10	)	)	-RRB-
cord-012902-efprpk72	538	11	was	be	VBD
cord-012902-efprpk72	538	12	estimated	estimate	VBN
cord-012902-efprpk72	538	13	from	from	IN
cord-012902-efprpk72	538	14	aortic	aortic	JJ
cord-012902-efprpk72	538	15	pulse	pulse	NN
cord-012902-efprpk72	538	16	pressure	pressure	NN
cord-012902-efprpk72	538	17	(	(	-LRB-
cord-012902-efprpk72	538	18	Arteriograph	Arteriograph	NNP
cord-012902-efprpk72	538	19	)	)	-RRB-
cord-012902-efprpk72	538	20	and	and	CC
cord-012902-efprpk72	538	21	carotid	carotid	JJ
cord-012902-efprpk72	538	22	lumen	lumen	JJ
cord-012902-efprpk72	538	23	area	area	NN
cord-012902-efprpk72	538	24	.	.	.
cord-012902-efprpk72	539	1	Data	datum	NNS
cord-012902-efprpk72	539	2	was	be	VBD
cord-012902-efprpk72	539	3	analysed	analyse	VBN
cord-012902-efprpk72	539	4	by	by	IN
cord-012902-efprpk72	539	5	modified	modify	VBN
cord-012902-efprpk72	539	6	intention	intention	NN
cord-012902-efprpk72	539	7	to	to	TO
cord-012902-efprpk72	539	8	treat	treat	VB
cord-012902-efprpk72	539	9	and	and	CC
cord-012902-efprpk72	539	10	using	use	VBG
cord-012902-efprpk72	539	11	mixedmodel	mixedmodel	NN
cord-012902-efprpk72	539	12	effect	effect	NN
cord-012902-efprpk72	539	13	,	,	,
cord-012902-efprpk72	539	14	adjusted	adjust	VBN
cord-012902-efprpk72	539	15	for	for	IN
cord-012902-efprpk72	539	16	confounders	confounder	NNS
cord-012902-efprpk72	539	17	.	.	.
cord-012902-efprpk72	540	1	Results	result	NNS
cord-012902-efprpk72	540	2	:	:	:
cord-012902-efprpk72	541	1	93	93	CD
cord-012902-efprpk72	541	2	subjects	subject	NNS
cord-012902-efprpk72	541	3	had	have	VBD
cord-012902-efprpk72	541	4	a	a	DT
cord-012902-efprpk72	541	5	baseline	baseline	JJ
cord-012902-efprpk72	541	6	evaluation	evaluation	NN
cord-012902-efprpk72	541	7	and	and	CC
cord-012902-efprpk72	541	8	86	86	CD
cord-012902-efprpk72	541	9	%	%	NN
cord-012902-efprpk72	541	10	had	have	VBD
cord-012902-efprpk72	541	11	follow	follow	VB
cord-012902-efprpk72	541	12	-	-	HYPH
cord-012902-efprpk72	541	13	up	up	RP
cord-012902-efprpk72	541	14	data	datum	NNS
cord-012902-efprpk72	541	15	.	.	.
cord-012902-efprpk72	542	1	No	no	DT
cord-012902-efprpk72	542	2	statistical	statistical	JJ
cord-012902-efprpk72	542	3	interactions	interaction	NNS
cord-012902-efprpk72	542	4	occurred	occur	VBD
cord-012902-efprpk72	542	5	between	between	IN
cord-012902-efprpk72	542	6	the	the	DT
cord-012902-efprpk72	542	7	juice	juice	NN
cord-012902-efprpk72	542	8	and	and	CC
cord-012902-efprpk72	542	9	drug	drug	NN
cord-012902-efprpk72	542	10	arms	arm	NNS
cord-012902-efprpk72	542	11	.	.	.
cord-012902-efprpk72	543	1	IMT	IMT	NNP
cord-012902-efprpk72	543	2	was	be	VBD
cord-012902-efprpk72	543	3	significantly	significantly	RB
cord-012902-efprpk72	543	4	lower	low	JJR
cord-012902-efprpk72	543	5	on	on	IN
cord-012902-efprpk72	543	6	nitrate	nitrate	NN
cord-012902-efprpk72	543	7	-	-	HYPH
cord-012902-efprpk72	543	8	containing	contain	VBG
cord-012902-efprpk72	543	9	compared	compare	VBN
cord-012902-efprpk72	543	10	with	with	IN
cord-012902-efprpk72	543	11	placebo	placebo	NN
cord-012902-efprpk72	543	12	juice	juice	NN
cord-012902-efprpk72	543	13	[	[	-LRB-
cord-012902-efprpk72	544	1	−0.06	−0.06	NNP
cord-012902-efprpk72	545	1	(	(	-LRB-
cord-012902-efprpk72	545	2	95	95	CD
cord-012902-efprpk72	545	3	%	%	NN
cord-012902-efprpk72	545	4	Confidence	confidence	NN
cord-012902-efprpk72	545	5	Interval	Interval	NNP
cord-012902-efprpk72	545	6	−0.12	−0.12	NNP
cord-012902-efprpk72	545	7	,	,	,
cord-012902-efprpk72	545	8	−0.01	−0.01	NNP
cord-012902-efprpk72	545	9	)	)	-RRB-
cord-012902-efprpk72	545	10	,	,	,
cord-012902-efprpk72	545	11	p	p	NN
cord-012902-efprpk72	545	12	=	=	SYM
cord-012902-efprpk72	545	13	0.022	0.022	CD
cord-012902-efprpk72	545	14	]	]	-RRB-
cord-012902-efprpk72	545	15	,	,	,
cord-012902-efprpk72	545	16	with	with	IN
cord-012902-efprpk72	545	17	no	no	DT
cord-012902-efprpk72	545	18	effect	effect	NN
cord-012902-efprpk72	545	19	on	on	IN
cord-012902-efprpk72	545	20	CD	CD	NNP
cord-012902-efprpk72	545	21	.	.	.
cord-012902-efprpk72	546	1	CS	CS	NNP
cord-012902-efprpk72	546	2	reduction	reduction	NN
cord-012902-efprpk72	546	3	was	be	VBD
cord-012902-efprpk72	546	4	similar	similar	JJ
cord-012902-efprpk72	546	5	between	between	IN
cord-012902-efprpk72	546	6	juices	juice	NNS
cord-012902-efprpk72	546	7	[	[	-LRB-
cord-012902-efprpk72	546	8	−0.38	−0.38	NNP
cord-012902-efprpk72	546	9	(	(	-LRB-
cord-012902-efprpk72	546	10	−0.67	−0.67	NNP
cord-012902-efprpk72	546	11	,	,	,
cord-012902-efprpk72	546	12	−0.10	−0.10	NNP
cord-012902-efprpk72	546	13	)	)	-RRB-
cord-012902-efprpk72	546	14	with	with	IN
cord-012902-efprpk72	546	15	placebo	placebo	NN
cord-012902-efprpk72	546	16	,	,	,
cord-012902-efprpk72	547	1	−0.13	−0.13	NNP
cord-012902-efprpk72	547	2	(	(	-LRB-
cord-012902-efprpk72	547	3	−0.42	−0.42	NNP
cord-012902-efprpk72	547	4	,	,	,
cord-012902-efprpk72	547	5	0.16	0.16	CD
cord-012902-efprpk72	547	6	)	)	-RRB-
cord-012902-efprpk72	547	7	with	with	IN
cord-012902-efprpk72	547	8	active	active	JJ
cord-012902-efprpk72	547	9	juice	juice	NN
cord-012902-efprpk72	547	10	]	]	-RRB-
cord-012902-efprpk72	547	11	and	and	CC
cord-012902-efprpk72	547	12	the	the	DT
cord-012902-efprpk72	547	13	drugs	drug	NNS
cord-012902-efprpk72	547	14	[	[	-LRB-
cord-012902-efprpk72	547	15	−0.30	−0.30	NNP
cord-012902-efprpk72	547	16	(	(	-LRB-
cord-012902-efprpk72	547	17	−0.58	−0.58	NNP
cord-012902-efprpk72	547	18	,	,	,
cord-012902-efprpk72	547	19	−0.02	−0.02	NNP
cord-012902-efprpk72	547	20	)	)	-RRB-
cord-012902-efprpk72	547	21	with	with	IN
cord-012902-efprpk72	547	22	doxazosin	doxazosin	NNP
cord-012902-efprpk72	547	23	,	,	.
cord-012902-efprpk72	548	1	−0.21	−0.21	NNP
cord-012902-efprpk72	548	2	(	(	-LRB-
cord-012902-efprpk72	548	3	−0.51	−0.51	NNP
cord-012902-efprpk72	548	4	,	,	,
cord-012902-efprpk72	548	5	0.09	0.09	CD
cord-012902-efprpk72	548	6	)	)	-RRB-
cord-012902-efprpk72	548	7	,	,	,
cord-012902-efprpk72	548	8	with	with	IN
cord-012902-efprpk72	548	9	spironolactone	spironolactone	NN
cord-012902-efprpk72	548	10	]	]	-RRB-
cord-012902-efprpk72	548	11	.	.	.
cord-012902-efprpk72	549	1	No	no	DT
cord-012902-efprpk72	549	2	differences	difference	NNS
cord-012902-efprpk72	549	3	were	be	VBD
cord-012902-efprpk72	549	4	detected	detect	VBN
cord-012902-efprpk72	549	5	between	between	IN
cord-012902-efprpk72	549	6	spironolactone	spironolactone	NN
cord-012902-efprpk72	549	7	or	or	CC
cord-012902-efprpk72	549	8	doxazosin	doxazosin	NNP
cord-012902-efprpk72	549	9	on	on	IN
cord-012902-efprpk72	549	10	IMT	IMT	NNP
cord-012902-efprpk72	549	11	and	and	CC
cord-012902-efprpk72	549	12	CD	CD	NNP
cord-012902-efprpk72	549	13	.	.	.
cord-012902-efprpk72	550	1	BP	BP	NNP
cord-012902-efprpk72	550	2	did	do	VBD
cord-012902-efprpk72	550	3	not	not	RB
cord-012902-efprpk72	550	4	differ	differ	VB
cord-012902-efprpk72	550	5	between	between	IN
cord-012902-efprpk72	550	6	the	the	DT
cord-012902-efprpk72	550	7	juices	juice	NNS
cord-012902-efprpk72	550	8	or	or	CC
cord-012902-efprpk72	550	9	between	between	IN
cord-012902-efprpk72	550	10	the	the	DT
cord-012902-efprpk72	550	11	drugs	drug	NNS
cord-012902-efprpk72	550	12	.	.	.
cord-012902-efprpk72	551	1	Conclusions	conclusion	NNS
cord-012902-efprpk72	551	2	:	:	:
cord-012902-efprpk72	552	1	Our	-PRON-	PRP$
cord-012902-efprpk72	552	2	exploratory	exploratory	JJ
cord-012902-efprpk72	552	3	results	result	NNS
cord-012902-efprpk72	552	4	show	show	VBP
cord-012902-efprpk72	552	5	that	that	IN
cord-012902-efprpk72	552	6	long	long	JJ
cord-012902-efprpk72	552	7	-	-	HYPH
cord-012902-efprpk72	552	8	term	term	NN
cord-012902-efprpk72	552	9	intervention	intervention	NN
cord-012902-efprpk72	552	10	with	with	IN
cord-012902-efprpk72	552	11	dietary	dietary	JJ
cord-012902-efprpk72	552	12	nitrate	nitrate	NN
cord-012902-efprpk72	552	13	influences	influence	NNS
cord-012902-efprpk72	552	14	vascular	vascular	JJ
cord-012902-efprpk72	552	15	remodelling	remodelling	NN
cord-012902-efprpk72	552	16	,	,	,
cord-012902-efprpk72	552	17	but	but	CC
cord-012902-efprpk72	552	18	not	not	RB
cord-012902-efprpk72	552	19	carotid	carotid	JJ
cord-012902-efprpk72	552	20	stiffness	stiffness	NN
cord-012902-efprpk72	552	21	or	or	CC
cord-012902-efprpk72	552	22	diameters	diameter	NNS
cord-012902-efprpk72	552	23	.	.	.
cord-012902-efprpk72	553	1	Neither	neither	CC
cord-012902-efprpk72	553	2	spironolactone	spironolactone	NN
cord-012902-efprpk72	553	3	nor	nor	CC
cord-012902-efprpk72	553	4	doxazosin	doxazosin	NNP
cord-012902-efprpk72	553	5	had	have	VBD
cord-012902-efprpk72	553	6	a	a	DT
cord-012902-efprpk72	553	7	BP	BP	NNP
cord-012902-efprpk72	553	8	-	-	HYPH
cord-012902-efprpk72	553	9	independent	independent	JJ
cord-012902-efprpk72	553	10	effect	effect	NN
cord-012902-efprpk72	553	11	on	on	IN
cord-012902-efprpk72	553	12	carotid	carotid	JJ
cord-012902-efprpk72	553	13	structure	structure	NN
cord-012902-efprpk72	553	14	and	and	CC
cord-012902-efprpk72	553	15	function	function	NN
cord-012902-efprpk72	553	16	.	.	.
cord-012902-efprpk72	554	1	Clinical	clinical	JJ
cord-012902-efprpk72	554	2	Trial	Trial	NNP
cord-012902-efprpk72	554	3	Registry	Registry	NNP
cord-012902-efprpk72	554	4	:	:	:
cord-012902-efprpk72	555	1	ISRCTN25003627	ISRCTN25003627	NNP
cord-012902-efprpk72	555	2	,	,	,
cord-012902-efprpk72	555	3	https://doi	https://doi	NNP
cord-012902-efprpk72	555	4	.	.	.
cord-012902-efprpk72	556	1	org/10.1186	org/10.1186	LS
cord-012902-efprpk72	556	2	/	/	SYM
cord-012902-efprpk72	556	3	ISRCTN25003627	isrctn25003627	JJ
cord-012902-efprpk72	556	4	Disclosures	disclosure	NNS
cord-012902-efprpk72	556	5	:	:	:
cord-012902-efprpk72	556	6	None	none	NN
cord-012902-efprpk72	556	7	.	.	.
cord-012902-efprpk72	557	1	decreased	decrease	VBD
cord-012902-efprpk72	557	2	with	with	IN
cord-012902-efprpk72	557	3	age	age	NN
cord-012902-efprpk72	557	4	in	in	IN
cord-012902-efprpk72	557	5	both	both	DT
cord-012902-efprpk72	557	6	males	male	NNS
cord-012902-efprpk72	557	7	and	and	CC
cord-012902-efprpk72	557	8	females	female	NNS
cord-012902-efprpk72	557	9	(	(	-LRB-
cord-012902-efprpk72	557	10	p	p	NN
cord-012902-efprpk72	557	11	<	<	XX
cord-012902-efprpk72	557	12	0.001	0.001	CD
cord-012902-efprpk72	557	13	for	for	IN
cord-012902-efprpk72	557	14	all	all	DT
cord-012902-efprpk72	557	15	)	)	-RRB-
cord-012902-efprpk72	557	16	.	.	.
cord-012902-efprpk72	558	1	However	however	RB
cord-012902-efprpk72	558	2	,	,	,
cord-012902-efprpk72	558	3	the	the	DT
cord-012902-efprpk72	558	4	LF	LF	NNP
cord-012902-efprpk72	558	5	/	/	SYM
cord-012902-efprpk72	558	6	HF	HF	NNP
cord-012902-efprpk72	558	7	ratio	ratio	NN
cord-012902-efprpk72	558	8	increased	increase	VBN
cord-012902-efprpk72	558	9	by	by	IN
cord-012902-efprpk72	558	10	decade	decade	NN
cord-012902-efprpk72	558	11	of	of	IN
cord-012902-efprpk72	558	12	life	life	NN
cord-012902-efprpk72	558	13	,	,	,
cord-012902-efprpk72	558	14	ranging	range	VBG
cord-012902-efprpk72	558	15	from	from	IN
cord-012902-efprpk72	558	16	<	<	XX
cord-012902-efprpk72	558	17	20years	20years	CD
cord-012902-efprpk72	558	18	(	(	-LRB-
cord-012902-efprpk72	558	19	1.14	1.14	CD
cord-012902-efprpk72	558	20	±	±	NNP
cord-012902-efprpk72	558	21	1.0	1.0	CD
cord-012902-efprpk72	558	22	)	)	-RRB-
cord-012902-efprpk72	558	23	to	to	IN
cord-012902-efprpk72	558	24	≥70years	≥70year	NNS
cord-012902-efprpk72	558	25	(	(	-LRB-
cord-012902-efprpk72	558	26	2.09	2.09	CD
cord-012902-efprpk72	558	27	±	±	CD
cord-012902-efprpk72	558	28	2.30	2.30	CD
cord-012902-efprpk72	558	29	)	)	-RRB-
cord-012902-efprpk72	558	30	,	,	,
cord-012902-efprpk72	558	31	p	p	NN
cord-012902-efprpk72	558	32	<	<	XX
cord-012902-efprpk72	558	33	0.01	0.01	CD
cord-012902-efprpk72	558	34	,	,	,
cord-012902-efprpk72	558	35	indicating	indicate	VBG
cord-012902-efprpk72	558	36	an	an	DT
cord-012902-efprpk72	558	37	increase	increase	NN
cord-012902-efprpk72	558	38	in	in	IN
cord-012902-efprpk72	558	39	sympathetic	sympathetic	JJ
cord-012902-efprpk72	558	40	dominance	dominance	NN
cord-012902-efprpk72	558	41	,	,	,
cord-012902-efprpk72	558	42	and	and	CC
cord-012902-efprpk72	558	43	this	this	DT
cord-012902-efprpk72	558	44	was	be	VBD
cord-012902-efprpk72	558	45	greater	great	JJR
cord-012902-efprpk72	558	46	in	in	IN
cord-012902-efprpk72	558	47	males	male	NNS
cord-012902-efprpk72	558	48	(	(	-LRB-
cord-012902-efprpk72	558	49	p	p	NN
cord-012902-efprpk72	558	50	<	<	XX
cord-012902-efprpk72	558	51	0.001	0.001	CD
cord-012902-efprpk72	558	52	)	)	-RRB-
cord-012902-efprpk72	558	53	.	.	.
cord-012902-efprpk72	559	1	The	the	DT
cord-012902-efprpk72	559	2	SphygmoCor	SphygmoCor	NNP
cord-012902-efprpk72	559	3	device	device	NN
cord-012902-efprpk72	559	4	provides	provide	VBZ
cord-012902-efprpk72	559	5	reproducible	reproducible	JJ
cord-012902-efprpk72	559	6	estimates	estimate	NNS
cord-012902-efprpk72	559	7	of	of	IN
cord-012902-efprpk72	559	8	HRV	HRV	NNP
cord-012902-efprpk72	559	9	indices	index	NNS
cord-012902-efprpk72	559	10	which	which	WDT
cord-012902-efprpk72	559	11	are	be	VBP
cord-012902-efprpk72	559	12	sensitive	sensitive	JJ
cord-012902-efprpk72	559	13	to	to	IN
cord-012902-efprpk72	559	14	the	the	DT
cord-012902-efprpk72	559	15	effects	effect	NNS
cord-012902-efprpk72	559	16	of	of	IN
cord-012902-efprpk72	559	17	ganglion	ganglion	NN
cord-012902-efprpk72	559	18	blockade	blockade	NN
cord-012902-efprpk72	559	19	,	,	,
cord-012902-efprpk72	559	20	postural	postural	JJ
cord-012902-efprpk72	559	21	change	change	NN
cord-012902-efprpk72	559	22	and	and	CC
cord-012902-efprpk72	559	23	ageing	ageing	NN
cord-012902-efprpk72	559	24	.	.	.
cord-012902-efprpk72	560	1	Assessment	assessment	NN
cord-012902-efprpk72	560	2	of	of	IN
cord-012902-efprpk72	560	3	ANS	ANS	NNP
cord-012902-efprpk72	560	4	may	may	MD
cord-012902-efprpk72	560	5	provide	provide	VB
cord-012902-efprpk72	560	6	useful	useful	JJ
cord-012902-efprpk72	560	7	insights	insight	NNS
cord-012902-efprpk72	560	8	into	into	IN
cord-012902-efprpk72	560	9	the	the	DT
cord-012902-efprpk72	560	10	cardiovascular	cardiovascular	JJ
cord-012902-efprpk72	560	11	effects	effect	NNS
cord-012902-efprpk72	560	12	of	of	IN
cord-012902-efprpk72	560	13	ageing	ageing	NN
cord-012902-efprpk72	560	14	and	and	CC
cord-012902-efprpk72	560	15	hypertension	hypertension	NN
cord-012902-efprpk72	560	16	.	.	.
cord-012902-efprpk72	561	1	Disclosures	disclosure	NNS
cord-012902-efprpk72	561	2	:	:	:
cord-012902-efprpk72	561	3	None	none	NN
cord-012902-efprpk72	561	4	.	.	.
cord-012902-efprpk72	562	1	Patients	patient	NNS
cord-012902-efprpk72	562	2	and	and	CC
cord-012902-efprpk72	562	3	animal	animal	NN
cord-012902-efprpk72	562	4	models	model	NNS
cord-012902-efprpk72	562	5	with	with	IN
cord-012902-efprpk72	562	6	acute	acute	JJ
cord-012902-efprpk72	562	7	and	and	CC
cord-012902-efprpk72	562	8	chronic	chronic	JJ
cord-012902-efprpk72	562	9	CVD	CVD	NNP
cord-012902-efprpk72	562	10	have	have	VBP
cord-012902-efprpk72	562	11	increased	increase	VBN
cord-012902-efprpk72	562	12	Spp1	Spp1	NNP
cord-012902-efprpk72	562	13	expression	expression	NN
cord-012902-efprpk72	562	14	in	in	IN
cord-012902-efprpk72	562	15	the	the	DT
cord-012902-efprpk72	562	16	heart	heart	NN
cord-012902-efprpk72	562	17	predominantly	predominantly	RB
cord-012902-efprpk72	562	18	within	within	IN
cord-012902-efprpk72	562	19	cardiomyocytes	cardiomyocyte	NNS
cord-012902-efprpk72	562	20	resulting	result	VBG
cord-012902-efprpk72	562	21	in	in	IN
cord-012902-efprpk72	562	22	cardiac	cardiac	JJ
cord-012902-efprpk72	562	23	hypertrophy	hypertrophy	NN
cord-012902-efprpk72	562	24	.	.	.
cord-012902-efprpk72	563	1	To	to	IN
cord-012902-efprpk72	563	2	date	date	NN
cord-012902-efprpk72	563	3	,	,	,
cord-012902-efprpk72	563	4	extracellular	extracellular	JJ
cord-012902-efprpk72	563	5	vesicles	vesicle	NNS
cord-012902-efprpk72	563	6	(	(	-LRB-
cord-012902-efprpk72	563	7	EV	ev	NN
cord-012902-efprpk72	563	8	)	)	-RRB-
cord-012902-efprpk72	563	9	transport	transport	NN
cord-012902-efprpk72	563	10	has	have	VBZ
cord-012902-efprpk72	563	11	been	be	VBN
cord-012902-efprpk72	563	12	shown	show	VBN
cord-012902-efprpk72	563	13	to	to	TO
cord-012902-efprpk72	563	14	facilitate	facilitate	VB
cord-012902-efprpk72	563	15	physiological	physiological	JJ
cord-012902-efprpk72	563	16	processes	process	NNS
cord-012902-efprpk72	563	17	,	,	,
cord-012902-efprpk72	563	18	such	such	JJ
cord-012902-efprpk72	563	19	as	as	IN
cord-012902-efprpk72	563	20	tissue	tissue	NN
cord-012902-efprpk72	563	21	repair	repair	NN
cord-012902-efprpk72	563	22	,	,	,
cord-012902-efprpk72	563	23	as	as	RB
cord-012902-efprpk72	563	24	well	well	RB
cord-012902-efprpk72	563	25	as	as	IN
cord-012902-efprpk72	563	26	pathological	pathological	JJ
cord-012902-efprpk72	563	27	processes	process	NNS
cord-012902-efprpk72	563	28	and	and	CC
cord-012902-efprpk72	563	29	may	may	MD
cord-012902-efprpk72	563	30	represent	represent	VB
cord-012902-efprpk72	563	31	a	a	DT
cord-012902-efprpk72	563	32	mechanism	mechanism	NN
cord-012902-efprpk72	563	33	contributing	contribute	VBG
cord-012902-efprpk72	563	34	to	to	IN
cord-012902-efprpk72	563	35	cardiomyocyte	cardiomyocyte	NNP
cord-012902-efprpk72	563	36	hypertrophy	hypertrophy	NN
cord-012902-efprpk72	563	37	.	.	.
cord-012902-efprpk72	564	1	Our	-PRON-	PRP$
cord-012902-efprpk72	564	2	aim	aim	NN
cord-012902-efprpk72	564	3	was	be	VBD
cord-012902-efprpk72	564	4	to	to	TO
cord-012902-efprpk72	564	5	measure	measure	VB
cord-012902-efprpk72	564	6	cell	cell	NN
cord-012902-efprpk72	564	7	size	size	NN
cord-012902-efprpk72	564	8	after	after	IN
cord-012902-efprpk72	564	9	overexpression	overexpression	NN
cord-012902-efprpk72	564	10	of	of	IN
cord-012902-efprpk72	564	11	Spp1	Spp1	NNP
cord-012902-efprpk72	564	12	in	in	IN
cord-012902-efprpk72	564	13	H9c2	H9c2	NNP
cord-012902-efprpk72	564	14	cells	cell	NNS
cord-012902-efprpk72	564	15	.	.	.
cord-012902-efprpk72	565	1	Furthermore	furthermore	RB
cord-012902-efprpk72	565	2	,	,	,
cord-012902-efprpk72	565	3	we	-PRON-	PRP
cord-012902-efprpk72	565	4	aimed	aim	VBD
cord-012902-efprpk72	565	5	to	to	TO
cord-012902-efprpk72	565	6	assess	assess	VB
cord-012902-efprpk72	565	7	functional	functional	JJ
cord-012902-efprpk72	565	8	role	role	NN
cord-012902-efprpk72	565	9	of	of	IN
cord-012902-efprpk72	565	10	EVs	ev	NNS
cord-012902-efprpk72	565	11	isolated	isolate	VBN
cord-012902-efprpk72	565	12	from	from	IN
cord-012902-efprpk72	565	13	Spp1	Spp1	NNP
cord-012902-efprpk72	565	14	transfected	transfecte	VBD
cord-012902-efprpk72	565	15	H9c2	H9c2	NNP
cord-012902-efprpk72	565	16	and	and	CC
cord-012902-efprpk72	565	17	HeLa	HeLa	NNP
cord-012902-efprpk72	565	18	conditioned	condition	VBN
cord-012902-efprpk72	565	19	media	medium	NNS
cord-012902-efprpk72	565	20	on	on	IN
cord-012902-efprpk72	565	21	H9c2	H9c2	NNP
cord-012902-efprpk72	565	22	cells	cell	NNS
cord-012902-efprpk72	565	23	.	.	.
cord-012902-efprpk72	566	1	Methods	method	NNS
cord-012902-efprpk72	566	2	:	:	:
cord-012902-efprpk72	566	3	H9c2	h9c2	NN
cord-012902-efprpk72	566	4	cells	cell	NNS
cord-012902-efprpk72	566	5	were	be	VBD
cord-012902-efprpk72	566	6	transfected	transfecte	VBN
cord-012902-efprpk72	566	7	with	with	IN
cord-012902-efprpk72	566	8	plasmid	plasmid	NN
cord-012902-efprpk72	566	9	control	control	NN
cord-012902-efprpk72	566	10	and	and	CC
cord-012902-efprpk72	566	11	Spp1	Spp1	NNP
cord-012902-efprpk72	566	12	.	.	.
cord-012902-efprpk72	567	1	48	48	CD
cord-012902-efprpk72	568	1	h	h	LS
cord-012902-efprpk72	568	2	post	post	NN
cord-012902-efprpk72	568	3	-	-	NN
cord-012902-efprpk72	568	4	transfection	transfection	JJ
cord-012902-efprpk72	568	5	,	,	,
cord-012902-efprpk72	568	6	cells	cell	NNS
cord-012902-efprpk72	568	7	were	be	VBD
cord-012902-efprpk72	568	8	fixed	fix	VBN
cord-012902-efprpk72	568	9	and	and	CC
cord-012902-efprpk72	568	10	stained	stain	VBN
cord-012902-efprpk72	568	11	with	with	IN
cord-012902-efprpk72	568	12	4	4	CD
cord-012902-efprpk72	568	13	%	%	NN
cord-012902-efprpk72	568	14	PFA	PFA	NNP
cord-012902-efprpk72	568	15	and	and	CC
cord-012902-efprpk72	568	16	2	2	CD
cord-012902-efprpk72	568	17	%	%	NN
cord-012902-efprpk72	568	18	crystal	crystal	NN
cord-012902-efprpk72	568	19	violet	violet	NN
cord-012902-efprpk72	568	20	stain	stain	NN
cord-012902-efprpk72	568	21	.	.	.
cord-012902-efprpk72	569	1	Cell	cell	NN
cord-012902-efprpk72	569	2	size	size	NN
cord-012902-efprpk72	569	3	was	be	VBD
cord-012902-efprpk72	569	4	measured	measure	VBN
cord-012902-efprpk72	569	5	using	use	VBG
cord-012902-efprpk72	569	6	ImageJ.	ImageJ.	NNP
cord-012902-efprpk72	569	7	EVs	ev	NNS
cord-012902-efprpk72	569	8	were	be	VBD
cord-012902-efprpk72	569	9	isolated	isolate	VBN
cord-012902-efprpk72	569	10	from	from	IN
cord-012902-efprpk72	569	11	H9c2	H9c2	NNP
cord-012902-efprpk72	569	12	and	and	CC
cord-012902-efprpk72	569	13	HeLa	HeLa	NNP
cord-012902-efprpk72	569	14	cells	cell	NNS
cord-012902-efprpk72	569	15	transfected	transfecte	VBN
cord-012902-efprpk72	569	16	with	with	IN
cord-012902-efprpk72	569	17	plasmid	plasmid	NN
cord-012902-efprpk72	569	18	control	control	NN
cord-012902-efprpk72	569	19	and	and	CC
cord-012902-efprpk72	569	20	Spp1	Spp1	NNP
cord-012902-efprpk72	569	21	by	by	IN
cord-012902-efprpk72	569	22	ultracentrifugation	ultracentrifugation	NN
cord-012902-efprpk72	569	23	technique	technique	NN
cord-012902-efprpk72	569	24	.	.	.
cord-012902-efprpk72	570	1	Isolated	isolated	JJ
cord-012902-efprpk72	570	2	EVs	ev	NNS
cord-012902-efprpk72	570	3	from	from	IN
cord-012902-efprpk72	570	4	H9c2	H9c2	NNP
cord-012902-efprpk72	570	5	and	and	CC
cord-012902-efprpk72	570	6	HeLa	HeLa	NNP
cord-012902-efprpk72	570	7	cells	cell	NNS
cord-012902-efprpk72	570	8	were	be	VBD
cord-012902-efprpk72	570	9	then	then	RB
cord-012902-efprpk72	570	10	placed	place	VBN
cord-012902-efprpk72	570	11	onto	onto	IN
cord-012902-efprpk72	570	12	fresh	fresh	JJ
cord-012902-efprpk72	570	13	H9c2	H9c2	NNP
cord-012902-efprpk72	570	14	cells	cell	NNS
cord-012902-efprpk72	570	15	and	and	CC
cord-012902-efprpk72	570	16	incubated	incubate	VBN
cord-012902-efprpk72	570	17	for	for	IN
cord-012902-efprpk72	570	18	48	48	CD
cord-012902-efprpk72	570	19	hours	hour	NNS
cord-012902-efprpk72	570	20	.	.	.
cord-012902-efprpk72	571	1	Post	post	JJ
cord-012902-efprpk72	571	2	-	-	JJ
cord-012902-efprpk72	571	3	incubation	incubation	JJ
cord-012902-efprpk72	571	4	cell	cell	NN
cord-012902-efprpk72	571	5	size	size	NN
cord-012902-efprpk72	571	6	was	be	VBD
cord-012902-efprpk72	571	7	measured	measure	VBN
cord-012902-efprpk72	571	8	using	use	VBG
cord-012902-efprpk72	571	9	ImageJ.	ImageJ.	NNP
cord-012902-efprpk72	571	10	Results	result	NNS
cord-012902-efprpk72	571	11	:	:	:
cord-012902-efprpk72	572	1	H9c2	h9c2	NN
cord-012902-efprpk72	572	2	cells	cell	NNS
cord-012902-efprpk72	572	3	transfected	transfecte	VBN
cord-012902-efprpk72	572	4	with	with	IN
cord-012902-efprpk72	572	5	Spp1	Spp1	NNP
cord-012902-efprpk72	572	6	showed	show	VBD
cord-012902-efprpk72	572	7	significant	significant	JJ
cord-012902-efprpk72	572	8	increase	increase	NN
cord-012902-efprpk72	572	9	in	in	IN
cord-012902-efprpk72	572	10	cell	cell	NN
cord-012902-efprpk72	572	11	size	size	NN
cord-012902-efprpk72	572	12	compared	compare	VBN
cord-012902-efprpk72	572	13	to	to	IN
cord-012902-efprpk72	572	14	their	-PRON-	PRP$
cord-012902-efprpk72	572	15	control	control	NN
cord-012902-efprpk72	572	16	(	(	-LRB-
cord-012902-efprpk72	572	17	pcDNA	pcdna	RB
cord-012902-efprpk72	572	18	48.3	48.3	CD
cord-012902-efprpk72	572	19	±	±	CD
cord-012902-efprpk72	572	20	0.5	0.5	CD
cord-012902-efprpk72	572	21	vs	vs	IN
cord-012902-efprpk72	572	22	Spp1	Spp1	NNP
cord-012902-efprpk72	572	23	112.0	112.0	CD
cord-012902-efprpk72	572	24	±	±	NNP
cord-012902-efprpk72	572	25	1.1	1.1	CD
cord-012902-efprpk72	572	26	,	,	,
cord-012902-efprpk72	572	27	p	p	NN
cord-012902-efprpk72	572	28	<	<	XX
cord-012902-efprpk72	572	29	0.05	0.05	CD
cord-012902-efprpk72	572	30	)	)	-RRB-
cord-012902-efprpk72	572	31	.	.	.
cord-012902-efprpk72	573	1	EVs	ev	NNS
cord-012902-efprpk72	573	2	isolated	isolate	VBN
cord-012902-efprpk72	573	3	from	from	IN
cord-012902-efprpk72	573	4	Spp1	Spp1	NNP
cord-012902-efprpk72	573	5	transfected	transfecte	VBN
cord-012902-efprpk72	573	6	H9c2	H9c2	NNP
cord-012902-efprpk72	573	7	cells	cell	NNS
cord-012902-efprpk72	573	8	showed	show	VBD
cord-012902-efprpk72	573	9	an	an	DT
cord-012902-efprpk72	573	10	increase	increase	NN
cord-012902-efprpk72	573	11	in	in	IN
cord-012902-efprpk72	573	12	cell	cell	NN
cord-012902-efprpk72	573	13	size	size	NN
cord-012902-efprpk72	573	14	compared	compare	VBN
cord-012902-efprpk72	573	15	to	to	IN
cord-012902-efprpk72	573	16	their	-PRON-	PRP$
cord-012902-efprpk72	573	17	control	control	NN
cord-012902-efprpk72	573	18	(	(	-LRB-
cord-012902-efprpk72	573	19	pcDNA	pcdna	DT
cord-012902-efprpk72	573	20	74.4	74.4	CD
cord-012902-efprpk72	573	21	±	±	CD
cord-012902-efprpk72	573	22	1.4	1.4	CD
cord-012902-efprpk72	573	23	vs	vs	IN
cord-012902-efprpk72	573	24	Spp1	Spp1	NNP
cord-012902-efprpk72	573	25	90.6	90.6	CD
cord-012902-efprpk72	573	26	±	±	NNP
cord-012902-efprpk72	573	27	1.6	1.6	CD
cord-012902-efprpk72	573	28	,	,	,
cord-012902-efprpk72	573	29	p	p	NN
cord-012902-efprpk72	573	30	<	<	XX
cord-012902-efprpk72	573	31	0.05	0.05	CD
cord-012902-efprpk72	573	32	)	)	-RRB-
cord-012902-efprpk72	573	33	.	.	.
cord-012902-efprpk72	574	1	Similarly	similarly	RB
cord-012902-efprpk72	574	2	,	,	,
cord-012902-efprpk72	574	3	EVs	ev	NNS
cord-012902-efprpk72	574	4	isolated	isolate	VBN
cord-012902-efprpk72	574	5	from	from	IN
cord-012902-efprpk72	574	6	Spp1	Spp1	NNP
cord-012902-efprpk72	574	7	transfected	transfecte	VBN
cord-012902-efprpk72	574	8	HeLa	HeLa	NNP
cord-012902-efprpk72	574	9	cells	cell	NNS
cord-012902-efprpk72	574	10	also	also	RB
cord-012902-efprpk72	574	11	showed	show	VBD
cord-012902-efprpk72	574	12	an	an	DT
cord-012902-efprpk72	574	13	increase	increase	NN
cord-012902-efprpk72	574	14	in	in	IN
cord-012902-efprpk72	574	15	H9c2	H9c2	NNP
cord-012902-efprpk72	574	16	cell	cell	NN
cord-012902-efprpk72	574	17	size	size	NN
cord-012902-efprpk72	574	18	compared	compare	VBN
cord-012902-efprpk72	574	19	to	to	IN
cord-012902-efprpk72	574	20	their	-PRON-	PRP$
cord-012902-efprpk72	574	21	control	control	NN
cord-012902-efprpk72	574	22	(	(	-LRB-
cord-012902-efprpk72	574	23	pcDNA	pcdna	RB
cord-012902-efprpk72	574	24	81.4	81.4	CD
cord-012902-efprpk72	574	25	±	±	CD
cord-012902-efprpk72	574	26	0.9	0.9	CD
cord-012902-efprpk72	574	27	vs	vs	IN
cord-012902-efprpk72	574	28	Spp1	Spp1	NNP
cord-012902-efprpk72	574	29	121.4	121.4	CD
cord-012902-efprpk72	574	30	±	±	NNP
cord-012902-efprpk72	574	31	2.0	2.0	CD
cord-012902-efprpk72	574	32	,	,	,
cord-012902-efprpk72	574	33	p	p	NN
cord-012902-efprpk72	574	34	<	<	XX
cord-012902-efprpk72	574	35	0.05	0.05	CD
cord-012902-efprpk72	574	36	)	)	-RRB-
cord-012902-efprpk72	574	37	.	.	.
cord-012902-efprpk72	575	1	Conclusions	conclusion	NNS
cord-012902-efprpk72	575	2	:	:	:
cord-012902-efprpk72	576	1	Over	over	RB
cord-012902-efprpk72	576	2	-	-	HYPH
cord-012902-efprpk72	576	3	expressing	express	VBG
cord-012902-efprpk72	576	4	Spp1	Spp1	NNP
cord-012902-efprpk72	576	5	in	in	IN
cord-012902-efprpk72	576	6	H9c2	H9c2	NNP
cord-012902-efprpk72	576	7	cells	cell	NNS
cord-012902-efprpk72	576	8	results	result	NNS
cord-012902-efprpk72	576	9	in	in	IN
cord-012902-efprpk72	576	10	significant	significant	JJ
cord-012902-efprpk72	576	11	increase	increase	NN
cord-012902-efprpk72	576	12	in	in	IN
cord-012902-efprpk72	576	13	cell	cell	NN
cord-012902-efprpk72	576	14	size	size	NN
cord-012902-efprpk72	576	15	,	,	,
cord-012902-efprpk72	576	16	suggesting	suggest	VBG
cord-012902-efprpk72	576	17	that	that	IN
cord-012902-efprpk72	576	18	it	-PRON-	PRP
cord-012902-efprpk72	576	19	likely	likely	RB
cord-012902-efprpk72	576	20	contributes	contribute	VBZ
cord-012902-efprpk72	576	21	to	to	IN
cord-012902-efprpk72	576	22	cardiac	cardiac	JJ
cord-012902-efprpk72	576	23	hypertrophy	hypertrophy	NN
cord-012902-efprpk72	576	24	in	in	IN
cord-012902-efprpk72	576	25	models	model	NNS
cord-012902-efprpk72	576	26	of	of	IN
cord-012902-efprpk72	576	27	CVD	CVD	NNP
cord-012902-efprpk72	576	28	.	.	.
cord-012902-efprpk72	577	1	This	this	DT
cord-012902-efprpk72	577	2	study	study	NN
cord-012902-efprpk72	577	3	also	also	RB
cord-012902-efprpk72	577	4	implicates	implicate	VBZ
cord-012902-efprpk72	577	5	the	the	DT
cord-012902-efprpk72	577	6	role	role	NN
cord-012902-efprpk72	577	7	of	of	IN
cord-012902-efprpk72	577	8	EVs	ev	NNS
cord-012902-efprpk72	577	9	in	in	IN
cord-012902-efprpk72	577	10	cardiac	cardiac	JJ
cord-012902-efprpk72	577	11	disease	disease	NN
cord-012902-efprpk72	577	12	and	and	CC
cord-012902-efprpk72	577	13	further	further	JJ
cord-012902-efprpk72	577	14	studies	study	NNS
cord-012902-efprpk72	577	15	will	will	MD
cord-012902-efprpk72	577	16	characterise	characterise	VB
cord-012902-efprpk72	577	17	their	-PRON-	PRP$
cord-012902-efprpk72	577	18	content	content	NN
cord-012902-efprpk72	577	19	to	to	TO
cord-012902-efprpk72	577	20	further	further	RB
cord-012902-efprpk72	577	21	elucidate	elucidate	VB
cord-012902-efprpk72	577	22	downstream	downstream	NN
cord-012902-efprpk72	577	23	mechanisms	mechanism	NNS
cord-012902-efprpk72	577	24	leading	lead	VBG
cord-012902-efprpk72	577	25	to	to	IN
cord-012902-efprpk72	577	26	cardiac	cardiac	JJ
cord-012902-efprpk72	577	27	hypertrophy	hypertrophy	NN
cord-012902-efprpk72	577	28	.	.	.
cord-012902-efprpk72	578	1	Disclosures	disclosure	NNS
cord-012902-efprpk72	578	2	:	:	:
cord-012902-efprpk72	579	1	The	the	DT
cord-012902-efprpk72	579	2	author	author	NN
cord-012902-efprpk72	579	3	declares	declare	VBZ
cord-012902-efprpk72	579	4	that	that	IN
cord-012902-efprpk72	579	5	there	there	EX
cord-012902-efprpk72	579	6	are	be	VBP
cord-012902-efprpk72	579	7	no	no	DT
cord-012902-efprpk72	579	8	competing	compete	VBG
cord-012902-efprpk72	579	9	interests	interest	NNS
cord-012902-efprpk72	579	10	associated	associate	VBN
cord-012902-efprpk72	579	11	with	with	IN
cord-012902-efprpk72	579	12	the	the	DT
cord-012902-efprpk72	579	13	abstract	abstract	NN
cord-012902-efprpk72	579	14	.	.	.
cord-012902-efprpk72	580	1	Measurement	Measurement	NNP
cord-012902-efprpk72	580	2	Month	Month	NNP
cord-012902-efprpk72	580	3	2018	2018	CD
cord-012902-efprpk72	580	4	:	:	:
cord-012902-efprpk72	580	5	a	a	DT
cord-012902-efprpk72	580	6	pragmatic	pragmatic	JJ
cord-012902-efprpk72	580	7	global	global	JJ
cord-012902-efprpk72	580	8	screening	screening	NN
cord-012902-efprpk72	580	9	campaign	campaign	NN
cord-012902-efprpk72	580	10	to	to	TO
cord-012902-efprpk72	580	11	raise	raise	VB
cord-012902-efprpk72	580	12	awareness	awareness	NN
cord-012902-efprpk72	580	13	of	of	IN
cord-012902-efprpk72	580	14	blood	blood	NN
cord-012902-efprpk72	580	15	pressure	pressure	NN
cord-012902-efprpk72	580	16	by	by	IN
cord-012902-efprpk72	580	17	the	the	DT
cord-012902-efprpk72	580	18	International	International	NNP
cord-012902-efprpk72	580	19	Society	Society	NNP
cord-012902-efprpk72	580	20	of	of	IN
cord-012902-efprpk72	580	21	Hypertension	Hypertension	NNP
cord-012902-efprpk72	581	1	The	the	DT
cord-012902-efprpk72	581	2	task	task	NN
cord-012902-efprpk72	581	3	force	force	NN
cord-012902-efprpk72	581	4	for	for	IN
cord-012902-efprpk72	581	5	the	the	DT
cord-012902-efprpk72	581	6	management	management	NN
cord-012902-efprpk72	581	7	of	of	IN
cord-012902-efprpk72	581	8	arterial	arterial	JJ
cord-012902-efprpk72	581	9	hypertension	hypertension	NN
cord-012902-efprpk72	581	10	of	of	IN
cord-012902-efprpk72	581	11	the	the	DT
cord-012902-efprpk72	581	12	European	European	NNP
cord-012902-efprpk72	581	13	Society	Society	NNP
cord-012902-efprpk72	581	14	of	of	IN
cord-012902-efprpk72	581	15	Cardiology	Cardiology	NNP
cord-012902-efprpk72	581	16	(	(	-LRB-
cord-012902-efprpk72	581	17	ESC	ESC	NNP
cord-012902-efprpk72	581	18	)	)	-RRB-
cord-012902-efprpk72	581	19	and	and	CC
cord-012902-efprpk72	581	20	the	the	DT
cord-012902-efprpk72	581	21	European	European	NNP
cord-012902-efprpk72	581	22	Society	Society	NNP
cord-012902-efprpk72	581	23	of	of	IN
cord-012902-efprpk72	581	24	Hypertension	Hypertension	NNP
cord-012902-efprpk72	581	25	Effectiveness	Effectiveness	NNP
cord-012902-efprpk72	581	26	of	of	IN
cord-012902-efprpk72	581	27	a	a	DT
cord-012902-efprpk72	581	28	barber	barber	NN
cord-012902-efprpk72	581	29	-	-	HYPH
cord-012902-efprpk72	581	30	based	base	VBN
cord-012902-efprpk72	581	31	intervention	intervention	NN
cord-012902-efprpk72	581	32	for	for	IN
cord-012902-efprpk72	581	33	improving	improve	VBG
cord-012902-efprpk72	581	34	hypertension	hypertension	NN
cord-012902-efprpk72	581	35	control	control	NN
cord-012902-efprpk72	581	36	in	in	IN
cord-012902-efprpk72	581	37	black	black	JJ
cord-012902-efprpk72	581	38	men	man	NNS
cord-012902-efprpk72	581	39	:	:	:
cord-012902-efprpk72	581	40	the	the	DT
cord-012902-efprpk72	581	41	BARBER-1	BARBER-1	NNP
cord-012902-efprpk72	581	42	study	study	NN
cord-012902-efprpk72	581	43	:	:	:
cord-012902-efprpk72	581	44	a	a	DT
cord-012902-efprpk72	581	45	cluster	cluster	NN
cord-012902-efprpk72	581	46	randomized	randomize	VBN
cord-012902-efprpk72	581	47	trial	trial	NN
cord-012902-efprpk72	581	48	Barbershops	barbershop	NNS
cord-012902-efprpk72	581	49	as	as	IN
cord-012902-efprpk72	581	50	hypertension	hypertension	NN
cord-012902-efprpk72	581	51	detection	detection	NN
cord-012902-efprpk72	581	52	,	,	,
cord-012902-efprpk72	581	53	referral	referral	NN
cord-012902-efprpk72	581	54	,	,	,
cord-012902-efprpk72	581	55	and	and	CC
cord-012902-efprpk72	581	56	follow	follow	VB
cord-012902-efprpk72	581	57	-	-	HYPH
cord-012902-efprpk72	581	58	up	up	RP
cord-012902-efprpk72	581	59	centers	center	NNS
cord-012902-efprpk72	581	60	for	for	IN
cord-012902-efprpk72	581	61	black	black	JJ
cord-012902-efprpk72	581	62	men	man	NNS
cord-012902-efprpk72	581	63	Variability	variability	NN
cord-012902-efprpk72	581	64	in	in	IN
cord-012902-efprpk72	581	65	low	low	JJ
cord-012902-efprpk72	581	66	-	-	HYPH
cord-012902-efprpk72	581	67	density	density	NN
cord-012902-efprpk72	581	68	lipoprotein	lipoprotein	NN
cord-012902-efprpk72	581	69	cholesterol	cholesterol	NN
cord-012902-efprpk72	581	70	and	and	CC
cord-012902-efprpk72	581	71	cardiovascular	cardiovascular	JJ
cord-012902-efprpk72	581	72	risk	risk	NN
cord-012902-efprpk72	581	73	:	:	:
cord-012902-efprpk72	581	74	should	should	MD
cord-012902-efprpk72	581	75	consistency	consistency	NN
cord-012902-efprpk72	581	76	be	be	VB
cord-012902-efprpk72	581	77	a	a	DT
cord-012902-efprpk72	581	78	new	new	JJ
cord-012902-efprpk72	581	79	target	target	NN
cord-012902-efprpk72	581	80	?	?	.
cord-012902-efprpk72	582	1	Visit	visit	VB
cord-012902-efprpk72	582	2	-	-	HYPH
cord-012902-efprpk72	582	3	to	to	IN
cord-012902-efprpk72	582	4	-	-	HYPH
cord-012902-efprpk72	582	5	visit	visit	VB
cord-012902-efprpk72	582	6	low	low	JJ
cord-012902-efprpk72	582	7	-	-	HYPH
cord-012902-efprpk72	582	8	density	density	NN
cord-012902-efprpk72	582	9	lipoprotein	lipoprotein	NN
cord-012902-efprpk72	582	10	cholesterol	cholesterol	NN
cord-012902-efprpk72	582	11	variability	variability	NN
cord-012902-efprpk72	582	12	and	and	CC
cord-012902-efprpk72	582	13	risk	risk	NN
cord-012902-efprpk72	582	14	of	of	IN
cord-012902-efprpk72	582	15	cardiovascular	cardiovascular	JJ
cord-012902-efprpk72	582	16	outcomes	outcome	NNS
cord-012902-efprpk72	582	17	:	:	:
cord-012902-efprpk72	582	18	insights	insight	NNS
cord-012902-efprpk72	582	19	from	from	IN
cord-012902-efprpk72	582	20	the	the	DT
cord-012902-efprpk72	582	21	TNT	TNT	NNP
cord-012902-efprpk72	582	22	trial	trial	NN
cord-012902-efprpk72	582	23	Long	long	JJ
cord-012902-efprpk72	582	24	-	-	HYPH
cord-012902-efprpk72	582	25	term	term	NN
cord-012902-efprpk72	582	26	effects	effect	NNS
cord-012902-efprpk72	582	27	of	of	IN
cord-012902-efprpk72	582	28	dietary	dietary	JJ
cord-012902-efprpk72	582	29	sodium	sodium	NN
cord-012902-efprpk72	582	30	reduction	reduction	NN
cord-012902-efprpk72	582	31	on	on	IN
cord-012902-efprpk72	582	32	cardiovascular	cardiovascular	JJ
cord-012902-efprpk72	582	33	disease	disease	NN
cord-012902-efprpk72	582	34	outcomes	outcome	NNS
cord-012902-efprpk72	582	35	:	:	:
cord-012902-efprpk72	582	36	observational	observational	JJ
cord-012902-efprpk72	582	37	follow	follow	NN
cord-012902-efprpk72	582	38	-	-	HYPH
cord-012902-efprpk72	582	39	up	up	NN
cord-012902-efprpk72	582	40	of	of	IN
cord-012902-efprpk72	582	41	the	the	DT
cord-012902-efprpk72	582	42	trials	trial	NNS
cord-012902-efprpk72	582	43	of	of	IN
cord-012902-efprpk72	582	44	hypertension	hypertension	NN
cord-012902-efprpk72	582	45	prevention	prevention	NN
cord-012902-efprpk72	582	46	(	(	-LRB-
cord-012902-efprpk72	582	47	TOHP	TOHP	NNP
cord-012902-efprpk72	582	48	)	)	-RRB-
cord-012902-efprpk72	583	1	Sodium	sodium	NN
cord-012902-efprpk72	583	2	and	and	CC
cord-012902-efprpk72	583	3	potassium	potassium	NN
cord-012902-efprpk72	583	4	intake	intake	NN
cord-012902-efprpk72	583	5	,	,	,
cord-012902-efprpk72	583	6	and	and	CC
cord-012902-efprpk72	583	7	knowledge	knowledge	NN
cord-012902-efprpk72	583	8	attitudes	attitude	NNS
cord-012902-efprpk72	583	9	and	and	CC
cord-012902-efprpk72	583	10	behaviour	behaviour	NN
cord-012902-efprpk72	583	11	towards	towards	IN
cord-012902-efprpk72	583	12	salt	salt	NN
cord-012902-efprpk72	583	13	consumption	consumption	NN
cord-012902-efprpk72	583	14	:	:	:
cord-012902-efprpk72	583	15	a	a	DT
cord-012902-efprpk72	583	16	national	national	JJ
cord-012902-efprpk72	583	17	survey	survey	NN
cord-012902-efprpk72	583	18	of	of	IN
cord-012902-efprpk72	583	19	adults	adult	NNS
cord-012902-efprpk72	583	20	in	in	IN
cord-012902-efprpk72	583	21	the	the	DT
cord-012902-efprpk72	583	22	Sultanate	Sultanate	NNP
cord-012902-efprpk72	583	23	of	of	IN
cord-012902-efprpk72	583	24	Oman	Oman	NNP
cord-012902-efprpk72	583	25	John	John	NNP
cord-012902-efprpk72	583	26	Idikula	Idikula	NNP
cord-012902-efprpk72	583	27	2	2	CD
cord-012902-efprpk72	583	28	,	,	,
cord-012902-efprpk72	583	29	Francesco	Francesco	NNP
cord-012902-efprpk72	583	30	Paolo	Paolo	NNP
cord-012902-efprpk72	583	31	Cappuccio	Cappuccio	NNP
cord-012902-efprpk72	583	32	1	1	CD
cord-012902-efprpk72	584	1	*	*	NFP
cord-012902-efprpk72	584	2	Reference	reference	NN
cord-012902-efprpk72	584	3	1	1	CD
cord-012902-efprpk72	584	4	.	.	.
cord-012902-efprpk72	585	1	Xianglong	Xianglong	NNP
cord-012902-efprpk72	585	2	Xu	Xu	NNP
cord-012902-efprpk72	585	3	et	et	NNP
cord-012902-efprpk72	585	4	al	al	NNP
cord-012902-efprpk72	585	5	.	.	.
cord-012902-efprpk72	586	1	HYpertension	HYpertension	NNP
cord-012902-efprpk72	586	2	Impact	Impact	NNP
cord-012902-efprpk72	586	3	on	on	IN
cord-012902-efprpk72	586	4	Healthrelated	Healthrelated	NNP
cord-012902-efprpk72	586	5	Quality	Quality	NNP
cord-012902-efprpk72	586	6	of	of	IN
cord-012902-efprpk72	586	7	Life	Life	NNP
cord-012902-efprpk72	586	8	:	:	:
cord-012902-efprpk72	587	1	A	a	DT
cord-012902-efprpk72	587	2	Cross	Cross	NNP
cord-012902-efprpk72	587	3	-	-	JJ
cord-012902-efprpk72	587	4	sectional	sectional	JJ
cord-012902-efprpk72	587	5	Survey	Survey	NNP
cord-012902-efprpk72	587	6	among	among	IN
cord-012902-efprpk72	587	7	Middle	Middle	NNP
cord-012902-efprpk72	587	8	-	-	HYPH
cord-012902-efprpk72	587	9	aged	aged	JJ
cord-012902-efprpk72	587	10	Adults	Adults	NNPS
cord-012902-efprpk72	587	11	in	in	IN
cord-012902-efprpk72	587	12	Chongqing	Chongqing	NNP
cord-012902-efprpk72	587	13	,	,	,
cord-012902-efprpk72	587	14	China	China	NNP
cord-012902-efprpk72	587	15	P-22	P-22	NNP
cord-012902-efprpk72	587	16	Early	early	JJ
cord-012902-efprpk72	587	17	hypertension	hypertension	NN
cord-012902-efprpk72	587	18	:	:	:
cord-012902-efprpk72	587	19	exploring	explore	VBG
cord-012902-efprpk72	587	20	the	the	DT
cord-012902-efprpk72	587	21	vascular	vascular	JJ
cord-012902-efprpk72	587	22	phenotype	phenotype	NN
cord-012902-efprpk72	587	23	Blood	blood	NN
cord-012902-efprpk72	587	24	pressure	pressure	NN
cord-012902-efprpk72	587	25	(	(	-LRB-
cord-012902-efprpk72	587	26	BP	BP	NNP
cord-012902-efprpk72	587	27	)	)	-RRB-
cord-012902-efprpk72	587	28	was	be	VBD
cord-012902-efprpk72	587	29	analysed	analyse	VBN
cord-012902-efprpk72	587	30	using	use	VBG
cord-012902-efprpk72	587	31	ambulatory	ambulatory	JJ
cord-012902-efprpk72	587	32	monitoring	monitoring	NN
cord-012902-efprpk72	587	33	.	.	.
cord-012902-efprpk72	588	1	Vascular	vascular	JJ
cord-012902-efprpk72	588	2	phenotyping	phenotyping	NN
cord-012902-efprpk72	588	3	included	include	VBD
cord-012902-efprpk72	588	4	flow	flow	NN
cord-012902-efprpk72	588	5	mediated	mediate	VBN
cord-012902-efprpk72	588	6	dilatation	dilatation	NN
cord-012902-efprpk72	588	7	(	(	-LRB-
cord-012902-efprpk72	588	8	FMD	FMD	NNP
cord-012902-efprpk72	588	9	)	)	-RRB-
cord-012902-efprpk72	588	10	,	,	,
cord-012902-efprpk72	588	11	pulse	pulse	NN
cord-012902-efprpk72	588	12	wave	wave	NN
cord-012902-efprpk72	588	13	velocity	velocity	NN
cord-012902-efprpk72	588	14	(	(	-LRB-
cord-012902-efprpk72	588	15	PWV	PWV	NNP
cord-012902-efprpk72	588	16	)	)	-RRB-
cord-012902-efprpk72	588	17	,	,	,
cord-012902-efprpk72	588	18	heart	heart	NN
cord-012902-efprpk72	588	19	-	-	HYPH
cord-012902-efprpk72	588	20	rate	rate	NN
cord-012902-efprpk72	588	21	adjusted	adjust	VBN
cord-012902-efprpk72	588	22	augmentation	augmentation	NN
cord-012902-efprpk72	588	23	index	index	NN
cord-012902-efprpk72	588	24	(	(	-LRB-
cord-012902-efprpk72	588	25	AI75	AI75	NNP
cord-012902-efprpk72	588	26	)	)	-RRB-
cord-012902-efprpk72	588	27	and	and	CC
cord-012902-efprpk72	588	28	estimated	estimate	VBN
cord-012902-efprpk72	588	29	central	central	JJ
cord-012902-efprpk72	588	30	BP	BP	NNP
cord-012902-efprpk72	588	31	by	by	IN
cord-012902-efprpk72	588	32	pulse	pulse	NN
cord-012902-efprpk72	588	33	wave	wave	NN
cord-012902-efprpk72	588	34	analysis	analysis	NN
cord-012902-efprpk72	588	35	(	(	-LRB-
cord-012902-efprpk72	588	36	PWA	PWA	NNP
cord-012902-efprpk72	588	37	)	)	-RRB-
cord-012902-efprpk72	588	38	;	;	:
cord-012902-efprpk72	588	39	and	and	CC
cord-012902-efprpk72	588	40	peripheral	peripheral	JJ
cord-012902-efprpk72	588	41	arterial	arterial	NN
cord-012902-efprpk72	588	42	tonometry	tonometry	NN
cord-012902-efprpk72	588	43	(	(	-LRB-
cord-012902-efprpk72	588	44	EndoPAT-2000)-generated	endopat-2000)-generated	JJ
cord-012902-efprpk72	588	45	logarithmic	logarithmic	NN
cord-012902-efprpk72	588	46	reactive	reactive	JJ
cord-012902-efprpk72	588	47	hyperaemia	hyperaemia	NN
cord-012902-efprpk72	588	48	index	index	NN
cord-012902-efprpk72	588	49	(	(	-LRB-
cord-012902-efprpk72	588	50	LnRH	LnRH	NNP
cord-012902-efprpk72	588	51	)	)	-RRB-
cord-012902-efprpk72	588	52	and	and	CC
cord-012902-efprpk72	589	1	AI75	AI75	NNP
cord-012902-efprpk72	589	2	.	.	.
cord-012902-efprpk72	589	3	Data	datum	NNS
cord-012902-efprpk72	589	4	were	be	VBD
cord-012902-efprpk72	589	5	entered	enter	VBN
cord-012902-efprpk72	589	6	into	into	IN
cord-012902-efprpk72	589	7	Principal	Principal	NNP
cord-012902-efprpk72	589	8	Component	Component	NNP
cord-012902-efprpk72	589	9	Analysis	Analysis	NNP
cord-012902-efprpk72	589	10	(	(	-LRB-
cord-012902-efprpk72	589	11	PCA	PCA	NNP
cord-012902-efprpk72	589	12	)	)	-RRB-
cord-012902-efprpk72	589	13	and	and	CC
cord-012902-efprpk72	589	14	heatmap	heatmap	NNP
cord-012902-efprpk72	589	15	generation	generation	NN
cord-012902-efprpk72	589	16	identified	identify	VBD
cord-012902-efprpk72	589	17	phenotypic	phenotypic	JJ
cord-012902-efprpk72	589	18	clusters	cluster	NNS
cord-012902-efprpk72	589	19	.	.	.
cord-012902-efprpk72	590	1	Results	result	NNS
cord-012902-efprpk72	590	2	:	:	:
cord-012902-efprpk72	591	1	Hypertensive	hypertensive	JJ
cord-012902-efprpk72	591	2	participants	participant	NNS
cord-012902-efprpk72	591	3	were	be	VBD
cord-012902-efprpk72	591	4	aged	aged	JJ
cord-012902-efprpk72	591	5	36	36	CD
cord-012902-efprpk72	591	6	±	±	CD
cord-012902-efprpk72	591	7	9.1	9.1	CD
cord-012902-efprpk72	592	1	,	,	,
cord-012902-efprpk72	592	2	79	79	CD
cord-012902-efprpk72	592	3	%	%	NN
cord-012902-efprpk72	592	4	were	be	VBD
cord-012902-efprpk72	592	5	male	male	JJ
cord-012902-efprpk72	592	6	,	,	,
cord-012902-efprpk72	592	7	24	24	CD
cord-012902-efprpk72	592	8	h	h	NN
cord-012902-efprpk72	592	9	SBP	SBP	NNP
cord-012902-efprpk72	592	10	was	be	VBD
cord-012902-efprpk72	592	11	140	140	CD
cord-012902-efprpk72	592	12	±	±	NNP
cord-012902-efprpk72	592	13	8	8	CD
cord-012902-efprpk72	592	14	(	(	-LRB-
cord-012902-efprpk72	592	15	vs	vs	IN
cord-012902-efprpk72	592	16	113	113	CD
cord-012902-efprpk72	592	17	±	±	NNP
cord-012902-efprpk72	592	18	9	9	CD
cord-012902-efprpk72	592	19	mmHg	mmhg	NN
cord-012902-efprpk72	592	20	BP	BP	NNP
cord-012902-efprpk72	592	21	141/91	141/91	CD
cord-012902-efprpk72	592	22	±	±	NNP
cord-012902-efprpk72	592	23	9/6	9/6	CD
cord-012902-efprpk72	592	24	mmHg	mmHg	NNS
cord-012902-efprpk72	592	25	,	,	,
cord-012902-efprpk72	592	26	with	with	IN
cord-012902-efprpk72	592	27	borderline	borderline	JJ
cord-012902-efprpk72	592	28	nocturnal	nocturnal	JJ
cord-012902-efprpk72	592	29	dip	dip	NN
cord-012902-efprpk72	592	30	(	(	-LRB-
cord-012902-efprpk72	592	31	0.3/12.7	0.3/12.7	CD
cord-012902-efprpk72	592	32	%	%	NN
cord-012902-efprpk72	592	33	)	)	-RRB-
cord-012902-efprpk72	592	34	,	,	,
cord-012902-efprpk72	592	35	relatively	relatively	RB
cord-012902-efprpk72	592	36	low	low	JJ
cord-012902-efprpk72	592	37	PWV	PWV	NNP
cord-012902-efprpk72	592	38	(	(	-LRB-
cord-012902-efprpk72	592	39	mean	mean	VB
cord-012902-efprpk72	592	40	6.9	6.9	CD
cord-012902-efprpk72	592	41	m	m	NN
cord-012902-efprpk72	592	42	/	/	SYM
cord-012902-efprpk72	592	43	s	s	NN
cord-012902-efprpk72	592	44	)	)	-RRB-
cord-012902-efprpk72	593	1	but	but	CC
cord-012902-efprpk72	593	2	elevated	elevated	JJ
cord-012902-efprpk72	593	3	AI75	AI75	NNP
cord-012902-efprpk72	593	4	by	by	IN
cord-012902-efprpk72	593	5	either	either	DT
cord-012902-efprpk72	593	6	measure	measure	NN
cord-012902-efprpk72	593	7	(	(	-LRB-
cord-012902-efprpk72	594	1	e.g.	e.g.	RB
cord-012902-efprpk72	594	2	mean	mean	VB
cord-012902-efprpk72	594	3	PWA	PWA	NNP
cord-012902-efprpk72	594	4	20	20	CD
cord-012902-efprpk72	594	5	%	%	NN
cord-012902-efprpk72	594	6	)	)	-RRB-
cord-012902-efprpk72	595	1	Diurnal	diurnal	JJ
cord-012902-efprpk72	595	2	variant	variant	NN
cord-012902-efprpk72	595	3	,	,	,
cord-012902-efprpk72	595	4	with	with	IN
cord-012902-efprpk72	595	5	daytime	daytime	JJ
cord-012902-efprpk72	595	6	BP	BP	NNP
cord-012902-efprpk72	595	7	143/	143/	CD
cord-012902-efprpk72	595	8	90	90	CD
cord-012902-efprpk72	595	9	mmHg	mmHg	NNS
cord-012902-efprpk72	595	10	,	,	,
cord-012902-efprpk72	595	11	but	but	CC
cord-012902-efprpk72	595	12	pronounced	pronounced	JJ
cord-012902-efprpk72	595	13	nocturnal	nocturnal	JJ
cord-012902-efprpk72	595	14	dip	dip	NN
cord-012902-efprpk72	595	15	(	(	-LRB-
cord-012902-efprpk72	595	16	14.6/21.1	14.6/21.1	CD
cord-012902-efprpk72	595	17	%	%	NN
cord-012902-efprpk72	595	18	)	)	-RRB-
cord-012902-efprpk72	595	19	and	and	CC
cord-012902-efprpk72	595	20	greater	great	JJR
cord-012902-efprpk72	595	21	SD	sd	NN
cord-012902-efprpk72	595	22	in	in	IN
cord-012902-efprpk72	595	23	daytime	daytime	JJ
cord-012902-efprpk72	595	24	BP	BP	NNP
cord-012902-efprpk72	595	25	(	(	-LRB-
cord-012902-efprpk72	595	26	12/9	12/9	CD
cord-012902-efprpk72	595	27	mmHg	mmHg	NNP
cord-012902-efprpk72	595	28	)	)	-RRB-
cord-012902-efprpk72	595	29	;	;	:
cord-012902-efprpk72	595	30	younger	young	JJR
cord-012902-efprpk72	595	31	age	age	NN
cord-012902-efprpk72	595	32	(	(	-LRB-
cord-012902-efprpk72	595	33	35	35	CD
cord-012902-efprpk72	595	34	years	year	NNS
cord-012902-efprpk72	595	35	)	)	-RRB-
cord-012902-efprpk72	595	36	,	,	,
cord-012902-efprpk72	595	37	lower	low	JJR
cord-012902-efprpk72	595	38	BMI	BMI	NNP
cord-012902-efprpk72	595	39	(	(	-LRB-
cord-012902-efprpk72	595	40	26	26	CD
cord-012902-efprpk72	595	41	kg	kg	NN
cord-012902-efprpk72	595	42	/	/	SYM
cord-012902-efprpk72	595	43	m	m	NN
cord-012902-efprpk72	595	44	2	2	CD
cord-012902-efprpk72	595	45	)	)	-RRB-
cord-012902-efprpk72	595	46	,	,	,
cord-012902-efprpk72	595	47	with	with	IN
cord-012902-efprpk72	595	48	intermediate	intermediate	JJ
cord-012902-efprpk72	595	49	PWV	PWV	NNP
cord-012902-efprpk72	595	50	(	(	-LRB-
cord-012902-efprpk72	595	51	7.3	7.3	CD
cord-012902-efprpk72	595	52	m	m	NN
cord-012902-efprpk72	595	53	/	/	SYM
cord-012902-efprpk72	595	54	s	s	NN
cord-012902-efprpk72	595	55	)	)	-RRB-
cord-012902-efprpk72	595	56	and	and	CC
cord-012902-efprpk72	595	57	AI75	AI75	NNP
cord-012902-efprpk72	595	58	(	(	-LRB-
cord-012902-efprpk72	595	59	−6.4	−6.4	CD
cord-012902-efprpk72	595	60	%	%	NN
cord-012902-efprpk72	595	61	)	)	-RRB-
cord-012902-efprpk72	595	62	,	,	,
cord-012902-efprpk72	595	63	and	and	CC
cord-012902-efprpk72	595	64	uniformly	uniformly	RB
cord-012902-efprpk72	595	65	normal	normal	JJ
cord-012902-efprpk72	595	66	LnRH	LnRH	NNP
cord-012902-efprpk72	595	67	.	.	.
cord-012902-efprpk72	596	1	Conclusions	conclusion	NNS
cord-012902-efprpk72	596	2	:	:	:
cord-012902-efprpk72	597	1	We	-PRON-	PRP
cord-012902-efprpk72	597	2	identify	identify	VBP
cord-012902-efprpk72	597	3	phenotypic	phenotypic	JJ
cord-012902-efprpk72	597	4	clusters	cluster	NNS
cord-012902-efprpk72	597	5	in	in	IN
cord-012902-efprpk72	597	6	incident	incident	NN
cord-012902-efprpk72	597	7	patients	patient	NNS
cord-012902-efprpk72	597	8	with	with	IN
cord-012902-efprpk72	597	9	primary	primary	JJ
cord-012902-efprpk72	597	10	hypertension	hypertension	NN
cord-012902-efprpk72	597	11	,	,	,
cord-012902-efprpk72	597	12	with	with	IN
cord-012902-efprpk72	597	13	different	different	JJ
cord-012902-efprpk72	597	14	vascular	vascular	JJ
cord-012902-efprpk72	597	15	techniques	technique	NNS
cord-012902-efprpk72	597	16	associated	associate	VBN
cord-012902-efprpk72	597	17	and	and	CC
cord-012902-efprpk72	597	18	potentially	potentially	RB
cord-012902-efprpk72	597	19	differing	differ	VBG
cord-012902-efprpk72	597	20	pathophysiology	pathophysiology	NN
cord-012902-efprpk72	597	21	Ethnic	ethnic	JJ
cord-012902-efprpk72	597	22	disparities	disparity	NNS
cord-012902-efprpk72	597	23	in	in	IN
cord-012902-efprpk72	597	24	hypertension	hypertension	NN
cord-012902-efprpk72	597	25	-	-	HYPH
cord-012902-efprpk72	597	26	mediated	mediate	VBN
cord-012902-efprpk72	597	27	organ	organ	NN
cord-012902-efprpk72	597	28	damage	damage	NN
cord-012902-efprpk72	597	29	and	and	CC
cord-012902-efprpk72	597	30	its	-PRON-	PRP$
cord-012902-efprpk72	597	31	usefulness	usefulness	NN
cord-012902-efprpk72	597	32	for	for	IN
cord-012902-efprpk72	597	33	the	the	DT
cord-012902-efprpk72	597	34	clinical	clinical	JJ
cord-012902-efprpk72	597	35	management	management	NN
cord-012902-efprpk72	597	36	of	of	IN
cord-012902-efprpk72	597	37	subjects	subject	NNS
cord-012902-efprpk72	597	38	with	with	IN
cord-012902-efprpk72	597	39	grade	grade	NN
cord-012902-efprpk72	598	1	I	-PRON-	PRP
cord-012902-efprpk72	598	2	hypertension	hypertension	NN
cord-012902-efprpk72	599	1	Ethnic	ethnic	JJ
cord-012902-efprpk72	599	2	disparities	disparity	NNS
cord-012902-efprpk72	599	3	in	in	IN
cord-012902-efprpk72	599	4	the	the	DT
cord-012902-efprpk72	599	5	prevalence	prevalence	NN
cord-012902-efprpk72	599	6	of	of	IN
cord-012902-efprpk72	599	7	hypertension	hypertension	NN
cord-012902-efprpk72	599	8	(	(	-LRB-
cord-012902-efprpk72	599	9	HT	HT	NNP
cord-012902-efprpk72	599	10	)	)	-RRB-
cord-012902-efprpk72	599	11	exist	exist	VBP
cord-012902-efprpk72	599	12	but	but	CC
cord-012902-efprpk72	599	13	data	datum	NNS
cord-012902-efprpk72	599	14	on	on	IN
cord-012902-efprpk72	599	15	target	target	NN
cord-012902-efprpk72	599	16	organ	organ	NN
cord-012902-efprpk72	599	17	damage	damage	NN
cord-012902-efprpk72	599	18	(	(	-LRB-
cord-012902-efprpk72	599	19	TOD	TOD	NNP
cord-012902-efprpk72	599	20	)	)	-RRB-
cord-012902-efprpk72	599	21	are	be	VBP
cord-012902-efprpk72	599	22	conflicting	conflict	VBG
cord-012902-efprpk72	599	23	[	[	-LRB-
cord-012902-efprpk72	599	24	1	1	CD
cord-012902-efprpk72	599	25	]	]	-RRB-
cord-012902-efprpk72	599	26	.	.	.
cord-012902-efprpk72	600	1	Here	here	RB
cord-012902-efprpk72	600	2	we	-PRON-	PRP
cord-012902-efprpk72	600	3	explore	explore	VBP
cord-012902-efprpk72	600	4	the	the	DT
cord-012902-efprpk72	600	5	ethnic	ethnic	JJ
cord-012902-efprpk72	600	6	differences	difference	NNS
cord-012902-efprpk72	600	7	in	in	IN
cord-012902-efprpk72	600	8	TOD	TOD	NNP
cord-012902-efprpk72	600	9	in	in	IN
cord-012902-efprpk72	600	10	a	a	DT
cord-012902-efprpk72	600	11	dual	dual	JJ
cord-012902-efprpk72	600	12	ethnic	ethnic	JJ
cord-012902-efprpk72	600	13	cohort	cohort	NN
cord-012902-efprpk72	600	14	of	of	IN
cord-012902-efprpk72	600	15	subject	subject	NN
cord-012902-efprpk72	600	16	with	with	IN
cord-012902-efprpk72	600	17	grade	grade	NN
cord-012902-efprpk72	600	18	I	-PRON-	PRP
cord-012902-efprpk72	600	19	HT	HT	NNP
cord-012902-efprpk72	600	20	and	and	CC
cord-012902-efprpk72	600	21	we	-PRON-	PRP
cord-012902-efprpk72	600	22	test	test	VBP
cord-012902-efprpk72	600	23	if	if	IN
cord-012902-efprpk72	600	24	the	the	DT
cord-012902-efprpk72	600	25	evaluation	evaluation	NN
cord-012902-efprpk72	600	26	of	of	IN
cord-012902-efprpk72	600	27	TOD	TOD	NNP
cord-012902-efprpk72	600	28	provides	provide	VBZ
cord-012902-efprpk72	600	29	additional	additional	JJ
cord-012902-efprpk72	600	30	information	information	NN
cord-012902-efprpk72	600	31	for	for	IN
cord-012902-efprpk72	600	32	the	the	DT
cord-012902-efprpk72	600	33	clinical	clinical	JJ
cord-012902-efprpk72	600	34	management	management	NN
cord-012902-efprpk72	600	35	of	of	IN
cord-012902-efprpk72	600	36	left	left	JJ
cord-012902-efprpk72	600	37	ventricular	ventricular	JJ
cord-012902-efprpk72	600	38	mass	mass	JJ
cord-012902-efprpk72	600	39	index	index	NN
cord-012902-efprpk72	600	40	(	(	-LRB-
cord-012902-efprpk72	600	41	LVMI	LVMI	NNP
cord-012902-efprpk72	600	42	,	,	,
cord-012902-efprpk72	600	43	cardiac	cardiac	JJ
cord-012902-efprpk72	600	44	ultrasound	ultrasound	NN
cord-012902-efprpk72	600	45	)	)	-RRB-
cord-012902-efprpk72	600	46	and	and	CC
cord-012902-efprpk72	600	47	carotid	carotid	JJ
cord-012902-efprpk72	600	48	-	-	HYPH
cord-012902-efprpk72	600	49	femoral	femoral	JJ
cord-012902-efprpk72	600	50	pulse	pulse	NN
cord-012902-efprpk72	600	51	wave	wave	NN
cord-012902-efprpk72	600	52	velocity	velocity	NN
cord-012902-efprpk72	600	53	(	(	-LRB-
cord-012902-efprpk72	600	54	cfPWV	cfpwv	NN
cord-012902-efprpk72	600	55	,	,	,
cord-012902-efprpk72	600	56	Sphygmocor	Sphygmocor	NNP
cord-012902-efprpk72	600	57	)	)	-RRB-
cord-012902-efprpk72	600	58	alongside	alongside	IN
cord-012902-efprpk72	600	59	with	with	IN
cord-012902-efprpk72	600	60	brachial	brachial	JJ
cord-012902-efprpk72	600	61	blood	blood	NN
cord-012902-efprpk72	600	62	pressure	pressure	NN
cord-012902-efprpk72	600	63	(	(	-LRB-
cord-012902-efprpk72	600	64	BP	BP	NNP
cord-012902-efprpk72	600	65	)	)	-RRB-
cord-012902-efprpk72	600	66	measurements	measurement	NNS
cord-012902-efprpk72	600	67	.	.	.
cord-012902-efprpk72	601	1	In	in	IN
cord-012902-efprpk72	601	2	untreated	untreated	JJ
cord-012902-efprpk72	601	3	subjects	subject	NNS
cord-012902-efprpk72	601	4	,	,	,
cord-012902-efprpk72	601	5	10-years	10-years	CD
cord-012902-efprpk72	601	6	CVR	CVR	NNP
cord-012902-efprpk72	601	7	was	be	VBD
cord-012902-efprpk72	601	8	estimated	estimate	VBN
cord-012902-efprpk72	601	9	using	use	VBG
cord-012902-efprpk72	601	10	QRISK3	QRISK3	NNP
cord-012902-efprpk72	601	11	calculator	calculator	NN
cord-012902-efprpk72	601	12	.	.	.
cord-012902-efprpk72	602	1	Results	result	NNS
cord-012902-efprpk72	602	2	:	:	:
cord-012902-efprpk72	603	1	58	58	CD
cord-012902-efprpk72	603	2	Black	black	JJ
cord-012902-efprpk72	603	3	(	(	-LRB-
cord-012902-efprpk72	603	4	26	26	CD
cord-012902-efprpk72	603	5	female	female	JJ
cord-012902-efprpk72	603	6	)	)	-RRB-
cord-012902-efprpk72	603	7	and	and	CC
cord-012902-efprpk72	603	8	61	61	CD
cord-012902-efprpk72	603	9	White	white	JJ
cord-012902-efprpk72	603	10	(	(	-LRB-
cord-012902-efprpk72	603	11	17	17	CD
cord-012902-efprpk72	603	12	female	female	JJ
cord-012902-efprpk72	603	13	)	)	-RRB-
cord-012902-efprpk72	603	14	subjects	subject	NNS
cord-012902-efprpk72	603	15	were	be	VBD
cord-012902-efprpk72	603	16	recruited	recruit	VBN
cord-012902-efprpk72	603	17	.	.	.
cord-012902-efprpk72	604	1	White	white	JJ
cord-012902-efprpk72	604	2	subjects	subject	NNS
cord-012902-efprpk72	604	3	were	be	VBD
cord-012902-efprpk72	604	4	older	old	JJR
cord-012902-efprpk72	604	5	compared	compare	VBN
cord-012902-efprpk72	604	6	to	to	IN
cord-012902-efprpk72	604	7	Black	black	JJ
cord-012902-efprpk72	604	8	ones	one	NNS
cord-012902-efprpk72	604	9	(	(	-LRB-
cord-012902-efprpk72	604	10	49	49	CD
cord-012902-efprpk72	604	11	vs	vs	IN
cord-012902-efprpk72	604	12	43	43	CD
cord-012902-efprpk72	604	13	years	year	NNS
cord-012902-efprpk72	604	14	)	)	-RRB-
cord-012902-efprpk72	604	15	but	but	CC
cord-012902-efprpk72	604	16	there	there	EX
cord-012902-efprpk72	604	17	were	be	VBD
cord-012902-efprpk72	604	18	no	no	DT
cord-012902-efprpk72	604	19	difference	difference	NN
cord-012902-efprpk72	604	20	in	in	IN
cord-012902-efprpk72	604	21	their	-PRON-	PRP$
cord-012902-efprpk72	604	22	duration	duration	NN
cord-012902-efprpk72	604	23	of	of	IN
cord-012902-efprpk72	604	24	hypertension	hypertension	NN
cord-012902-efprpk72	604	25	(	(	-LRB-
cord-012902-efprpk72	604	26	~4.5	~4.5	CD
cord-012902-efprpk72	604	27	years	year	NNS
cord-012902-efprpk72	604	28	)	)	-RRB-
cord-012902-efprpk72	604	29	and	and	CC
cord-012902-efprpk72	604	30	BP	BP	NNP
cord-012902-efprpk72	604	31	(	(	-LRB-
cord-012902-efprpk72	604	32	(	(	-LRB-
cord-012902-efprpk72	604	33	mean	mean	JJ
cord-012902-efprpk72	604	34	±	±	NNP
cord-012902-efprpk72	604	35	standard	standard	JJ
cord-012902-efprpk72	604	36	error	error	NN
cord-012902-efprpk72	604	37	)	)	-RRB-
cord-012902-efprpk72	605	1	146after	146after	JJ
cord-012902-efprpk72	605	2	adjustment	adjustment	NN
cord-012902-efprpk72	605	3	for	for	IN
cord-012902-efprpk72	605	4	confounders	confounder	NNS
cord-012902-efprpk72	605	5	(	(	-LRB-
cord-012902-efprpk72	605	6	BP	BP	NNP
cord-012902-efprpk72	605	7	,	,	,
cord-012902-efprpk72	605	8	age	age	NN
cord-012902-efprpk72	605	9	,	,	,
cord-012902-efprpk72	605	10	gender	gender	NN
cord-012902-efprpk72	605	11	,	,	,
cord-012902-efprpk72	605	12	body	body	NN
cord-012902-efprpk72	605	13	mass	mass	NN
cord-012902-efprpk72	605	14	index	index	NN
cord-012902-efprpk72	605	15	,	,	,
cord-012902-efprpk72	605	16	creatinine	creatinine	NN
cord-012902-efprpk72	605	17	,	,	,
cord-012902-efprpk72	605	18	diabetes	diabetes	NN
cord-012902-efprpk72	605	19	and	and	CC
cord-012902-efprpk72	605	20	dyslipidaemia	dyslipidaemia	NN
cord-012902-efprpk72	605	21	)	)	-RRB-
cord-012902-efprpk72	605	22	Left	left	JJ
cord-012902-efprpk72	605	23	-	-	HYPH
cord-012902-efprpk72	605	24	ventricular	ventricular	JJ
cord-012902-efprpk72	605	25	structure	structure	NN
cord-012902-efprpk72	605	26	in	in	IN
cord-012902-efprpk72	605	27	the	the	DT
cord-012902-efprpk72	605	28	Southall	Southall	NNP
cord-012902-efprpk72	605	29	And	and	CC
cord-012902-efprpk72	605	30	Brent	Brent	NNP
cord-012902-efprpk72	605	31	REvisited	REvisited	NNP
cord-012902-efprpk72	605	32	(	(	-LRB-
cord-012902-efprpk72	605	33	SABRE	SABRE	NNP
cord-012902-efprpk72	605	34	)	)	-RRB-
cord-012902-efprpk72	605	35	study	study	NN
cord-012902-efprpk72	605	36	:	:	:
cord-012902-efprpk72	606	1	explaining	explain	VBG
cord-012902-efprpk72	606	2	ethnic	ethnic	JJ
cord-012902-efprpk72	606	3	differences	difference	NNS
cord-012902-efprpk72	606	4	Dietary	dietary	JJ
cord-012902-efprpk72	606	5	nitrate	nitrate	NN
cord-012902-efprpk72	606	6	influences	influence	NNS
cord-012902-efprpk72	606	7	vascular	vascular	JJ
cord-012902-efprpk72	606	8	remodelling	remodelling	NN
cord-012902-efprpk72	606	9	through	through	IN
cord-012902-efprpk72	606	10	BP	BP	NNP
cord-012902-efprpk72	606	11	-	-	HYPH
cord-012902-efprpk72	606	12	independent	independent	JJ
cord-012902-efprpk72	606	13	mechanisms	mechanism	NNS
cord-012902-efprpk72	606	14	in	in	IN
cord-012902-efprpk72	606	15	patients	patient	NNS
cord-012902-efprpk72	606	16	with	with	IN
cord-012902-efprpk72	606	17	or	or	CC
cord-012902-efprpk72	606	18	at	at	IN
cord-012902-efprpk72	606	19	risk	risk	NN
cord-012902-efprpk72	606	20	of	of	IN
cord-012902-efprpk72	606	21	type	type	NN
cord-012902-efprpk72	606	22	2	2	CD
cord-012902-efprpk72	606	23	diabetes	diabetes	NN
cord-012902-efprpk72	606	24	mellitus	mellitus	NN
cord-012902-efprpk72	606	25	:	:	:
cord-012902-efprpk72	606	26	results	result	NNS
cord-012902-efprpk72	606	27	from	from	IN
cord-012902-efprpk72	606	28	the	the	DT
cord-012902-efprpk72	606	29	double	double	JJ
cord-012902-efprpk72	606	30	-	-	HYPH
cord-012902-efprpk72	606	31	blind	blind	JJ
cord-012902-efprpk72	606	32	Mills	mill	NNS
cord-012902-efprpk72	606	33	2,3	2,3	CD
cord-012902-efprpk72	606	34	,	,	,
cord-012902-efprpk72	606	35	Steve	Steve	NNP
cord-012902-efprpk72	606	36	Morant	Morant	NNP
cord-012902-efprpk72	606	37	4	4	CD
cord-012902-efprpk72	607	1	It	-PRON-	PRP
cord-012902-efprpk72	607	2	is	be	VBZ
cord-012902-efprpk72	607	3	rocket	rocket	NN
cord-012902-efprpk72	607	4	science	science	NN
cord-012902-efprpk72	607	5	-	-	HYPH
cord-012902-efprpk72	607	6	why	why	WRB
cord-012902-efprpk72	607	7	dietary	dietary	JJ
cord-012902-efprpk72	607	8	nitrate	nitrate	NN
cord-012902-efprpk72	607	9	is	be	VBZ
cord-012902-efprpk72	607	10	hard	hard	JJ
cord-012902-efprpk72	607	11	to	to	TO
cord-012902-efprpk72	607	12	'	'	``
cord-012902-efprpk72	607	13	beet	beet	NN
cord-012902-efprpk72	607	14	'	'	''
cord-012902-efprpk72	607	15	!	!	.
cord-012902-efprpk72	608	1	Part	part	NN
cord-012902-efprpk72	608	2	II	II	NNP
cord-012902-efprpk72	608	3	:	:	:
cord-012902-efprpk72	608	4	further	further	JJ
cord-012902-efprpk72	608	5	mechanisms	mechanism	NNS
cord-012902-efprpk72	608	6	and	and	CC
cord-012902-efprpk72	608	7	therapeutic	therapeutic	JJ
cord-012902-efprpk72	608	8	potential	potential	NN
cord-012902-efprpk72	608	9	of	of	IN
cord-012902-efprpk72	608	10	the	the	DT
cord-012902-efprpk72	608	11	nitrate	nitrate	NN
cord-012902-efprpk72	608	12	-	-	HYPH
cord-012902-efprpk72	608	13	nitrite	nitrite	NN
cord-012902-efprpk72	608	14	-	-	HYPH
cord-012902-efprpk72	608	15	NO	no	DT
cord-012902-efprpk72	608	16	pathway	pathway	NN
cord-012902-efprpk72	608	17	A	a	DT
cord-012902-efprpk72	608	18	randomised	randomised	JJ
cord-012902-efprpk72	608	19	,	,	,
cord-012902-efprpk72	608	20	factorial	factorial	JJ
cord-012902-efprpk72	608	21	trial	trial	NN
cord-012902-efprpk72	608	22	to	to	TO
cord-012902-efprpk72	608	23	reduce	reduce	VB
cord-012902-efprpk72	608	24	arterial	arterial	JJ
cord-012902-efprpk72	608	25	stiffness	stiffness	NN
cord-012902-efprpk72	608	26	independently	independently	RB
cord-012902-efprpk72	608	27	of	of	IN
cord-012902-efprpk72	608	28	blood	blood	NN
cord-012902-efprpk72	608	29	pressure	pressure	NN
cord-012902-efprpk72	608	30	:	:	:
cord-012902-efprpk72	608	31	Proof	proof	NN
cord-012902-efprpk72	608	32	of	of	IN
cord-012902-efprpk72	608	33	concept	concept	NN
cord-012902-efprpk72	608	34	?	?	.
cord-012902-efprpk72	609	1	The	the	DT
cord-012902-efprpk72	609	2	'	'	``
cord-012902-efprpk72	609	3	VaSera	VaSera	NNP
cord-012902-efprpk72	609	4	'	'	POS
cord-012902-efprpk72	609	5	trial	trial	NN
cord-012902-efprpk72	609	6	testing	testing	NN
cord-012902-efprpk72	609	7	dietary	dietary	JJ
cord-012902-efprpk72	609	8	nitrate	nitrate	NN
cord-012902-efprpk72	609	9	and	and	CC
cord-012902-efprpk72	609	10	spironolactone	spironolactone	NN
cord-012902-efprpk72	609	11	Reducing	reduce	VBG
cord-012902-efprpk72	609	12	Arterial	Arterial	NNP
cord-012902-efprpk72	609	13	Stiffness	Stiffness	NNP
cord-012902-efprpk72	610	1	Independently	independently	RB
cord-012902-efprpk72	610	2	of	of	IN
cord-012902-efprpk72	610	3	Blood	blood	NN
cord-012902-efprpk72	610	4	Pressure	pressure	NN
cord-012902-efprpk72	610	5	Methods	method	NNS
cord-012902-efprpk72	610	6	:	:	:
cord-012902-efprpk72	610	7	We	-PRON-	PRP
cord-012902-efprpk72	610	8	conducted	conduct	VBD
cord-012902-efprpk72	610	9	3	3	CD
cord-012902-efprpk72	610	10	separate	separate	JJ
cord-012902-efprpk72	610	11	studies	study	NNS
cord-012902-efprpk72	610	12	:	:	:
cord-012902-efprpk72	611	1	(	(	-LRB-
cord-012902-efprpk72	611	2	1	1	LS
cord-012902-efprpk72	611	3	)	)	-RRB-
cord-012902-efprpk72	611	4	Effect	effect	NN
cord-012902-efprpk72	611	5	of	of	IN
cord-012902-efprpk72	611	6	ganglion	ganglion	NN
cord-012902-efprpk72	611	7	blockade	blockade	NN
cord-012902-efprpk72	611	8	with	with	IN
cord-012902-efprpk72	611	9	pentolinium	pentolinium	NN
cord-012902-efprpk72	611	10	(	(	-LRB-
cord-012902-efprpk72	611	11	5mg/5ml	5mg/5ml	CD
cord-012902-efprpk72	611	12	bolus	bolus	NN
cord-012902-efprpk72	611	13	)	)	-RRB-
cord-012902-efprpk72	611	14	on	on	IN
cord-012902-efprpk72	611	15	HRV	HRV	NNP
cord-012902-efprpk72	611	16	was	be	VBD
cord-012902-efprpk72	611	17	studied	study	VBN
cord-012902-efprpk72	611	18	in	in	IN
cord-012902-efprpk72	611	19	9	9	CD
cord-012902-efprpk72	611	20	healthy	healthy	JJ
cord-012902-efprpk72	611	21	volunteers	volunteer	NNS
cord-012902-efprpk72	611	22	,	,	,
cord-012902-efprpk72	611	23	(	(	-LRB-
cord-012902-efprpk72	611	24	4	4	CD
cord-012902-efprpk72	611	25	females	female	NNS
cord-012902-efprpk72	611	26	,	,	,
cord-012902-efprpk72	611	27	28	28	CD
cord-012902-efprpk72	611	28	±	±	CD
cord-012902-efprpk72	611	29	6	6	CD
cord-012902-efprpk72	611	30	years	year	NNS
cord-012902-efprpk72	611	31	)	)	-RRB-
cord-012902-efprpk72	611	32	.	.	.
cord-012902-efprpk72	612	1	(	(	-LRB-
cord-012902-efprpk72	612	2	2	2	LS
cord-012902-efprpk72	612	3	)	)	-RRB-
cord-012902-efprpk72	612	4	Repeatability	repeatability	NN
cord-012902-efprpk72	612	5	and	and	CC
cord-012902-efprpk72	612	6	effect	effect	NN
cord-012902-efprpk72	612	7	of	of	IN
cord-012902-efprpk72	612	8	postural	postural	JJ
cord-012902-efprpk72	612	9	change	change	NN
cord-012902-efprpk72	612	10	(	(	-LRB-
cord-012902-efprpk72	612	11	supine	supine	JJ
cord-012902-efprpk72	612	12	,	,	,
cord-012902-efprpk72	612	13	seated	seated	JJ
cord-012902-efprpk72	612	14	and	and	CC
cord-012902-efprpk72	612	15	standing	stand	VBG
cord-012902-efprpk72	612	16	,	,	,
cord-012902-efprpk72	612	17	measured	measure	VBN
cord-012902-efprpk72	612	18	on	on	IN
cord-012902-efprpk72	612	19	two	two	CD
cord-012902-efprpk72	612	20	occasions	occasion	NNS
cord-012902-efprpk72	612	21	)	)	-RRB-
cord-012902-efprpk72	612	22	were	be	VBD
cord-012902-efprpk72	612	23	investigated	investigate	VBN
cord-012902-efprpk72	612	24	in	in	IN
cord-012902-efprpk72	612	25	15	15	CD
cord-012902-efprpk72	612	26	healthy	healthy	JJ
cord-012902-efprpk72	612	27	volunteers	volunteer	NNS
cord-012902-efprpk72	612	28	(	(	-LRB-
cord-012902-efprpk72	612	29	8	8	CD
cord-012902-efprpk72	612	30	females	female	NNS
cord-012902-efprpk72	612	31	,	,	,
cord-012902-efprpk72	612	32	32	32	CD
cord-012902-efprpk72	612	33	±	±	CD
cord-012902-efprpk72	612	34	11	11	CD
cord-012902-efprpk72	612	35	years	year	NNS
cord-012902-efprpk72	612	36	)	)	-RRB-
cord-012902-efprpk72	612	37	.	.	.
cord-012902-efprpk72	613	1	(	(	-LRB-
cord-012902-efprpk72	613	2	3	3	LS
cord-012902-efprpk72	613	3	)	)	-RRB-
cord-012902-efprpk72	613	4	Influence	influence	NN
cord-012902-efprpk72	613	5	of	of	IN
cord-012902-efprpk72	613	6	age	age	NN
cord-012902-efprpk72	613	7	and	and	CC
cord-012902-efprpk72	613	8	sex	sex	NN
cord-012902-efprpk72	613	9	on	on	IN
cord-012902-efprpk72	613	10	HRV	HRV	NNP
cord-012902-efprpk72	613	11	indices	index	NNS
cord-012902-efprpk72	613	12	were	be	VBD
cord-012902-efprpk72	613	13	observed	observe	VBN
cord-012902-efprpk72	613	14	in	in	IN
cord-012902-efprpk72	613	15	1858	1858	CD
cord-012902-efprpk72	613	16	healthy	healthy	JJ
cord-012902-efprpk72	613	17	individuals	individual	NNS
cord-012902-efprpk72	613	18	(	(	-LRB-
cord-012902-efprpk72	613	19	971	971	CD
cord-012902-efprpk72	613	20	females	female	NNS
cord-012902-efprpk72	613	21	,	,	,
cord-012902-efprpk72	613	22	37	37	CD
cord-012902-efprpk72	613	23	±	±	CD
cord-012902-efprpk72	613	24	19	19	CD
cord-012902-efprpk72	613	25	years	year	NNS
cord-012902-efprpk72	613	26	,	,	,
cord-012902-efprpk72	614	1	range	range	NNP
cord-012902-efprpk72	614	2	16	16	CD
cord-012902-efprpk72	614	3	-	-	SYM
cord-012902-efprpk72	614	4	84	84	CD
cord-012902-efprpk72	614	5	years	year	NNS
cord-012902-efprpk72	614	6	)	)	-RRB-
cord-012902-efprpk72	614	7	.	.	.
cord-012902-efprpk72	615	1	All	all	DT
cord-012902-efprpk72	615	2	measurements	measurement	NNS
cord-012902-efprpk72	615	3	for	for	IN
cord-012902-efprpk72	615	4	all	all	DT
cord-012902-efprpk72	615	5	studies	study	NNS
cord-012902-efprpk72	615	6	were	be	VBD
cord-012902-efprpk72	615	7	made	make	VBN
cord-012902-efprpk72	615	8	for	for	IN
cord-012902-efprpk72	615	9	a	a	DT
cord-012902-efprpk72	615	10	minimum	minimum	NN
cord-012902-efprpk72	615	11	of	of	IN
cord-012902-efprpk72	615	12	5	5	CD
cord-012902-efprpk72	615	13	min	min	NN
cord-012902-efprpk72	615	14	LF	lf	NN
cord-012902-efprpk72	615	15	power	power	NN
cord-012902-efprpk72	615	16	(	(	-LRB-
cord-012902-efprpk72	615	17	1094	1094	CD
cord-012902-efprpk72	615	18	±	±	NNP
cord-012902-efprpk72	615	19	825	825	CD
cord-012902-efprpk72	615	20	vs.	vs.	NN
cord-012902-efprpk72	615	21	316	316	CD
cord-012902-efprpk72	615	22	±	±	CD
cord-012902-efprpk72	615	23	613	613	CD
cord-012902-efprpk72	616	1	ms	ms	NNP
cord-012902-efprpk72	616	2	2	2	CD
cord-012902-efprpk72	616	3	,	,	,
cord-012902-efprpk72	616	4	p	p	NN
cord-012902-efprpk72	616	5	=	=	SYM
cord-012902-efprpk72	616	6	0.01	0.01	CD
cord-012902-efprpk72	616	7	)	)	-RRB-
cord-012902-efprpk72	616	8	and	and	CC
cord-012902-efprpk72	616	9	total	total	JJ
cord-012902-efprpk72	616	10	power	power	NN
cord-012902-efprpk72	616	11	(	(	-LRB-
cord-012902-efprpk72	616	12	3327	3327	CD
cord-012902-efprpk72	616	13	±	±	CD
cord-012902-efprpk72	616	14	2345	2345	CD
cord-012902-efprpk72	616	15	vs.	vs.	IN
cord-012902-efprpk72	616	16	1024	1024	CD
cord-012902-efprpk72	616	17	±	±	CD
cord-012902-efprpk72	616	18	1711	1711	CD
cord-012902-efprpk72	617	1	ms	ms	NNP
cord-012902-efprpk72	617	2	2	2	CD
cord-012902-efprpk72	617	3	,	,	,
cord-012902-efprpk72	617	4	p	p	NN
cord-012902-efprpk72	617	5	=	=	SYM
cord-012902-efprpk72	617	6	0.001	0.001	CD
cord-012902-efprpk72	617	7	)	)	-RRB-
cord-012902-efprpk72	617	8	Introduction	introduction	NN
cord-012902-efprpk72	617	9	:	:	:
cord-012902-efprpk72	618	1	Cardiovascular	cardiovascular	JJ
cord-012902-efprpk72	618	2	morbidity	morbidity	NN
cord-012902-efprpk72	618	3	and	and	CC
cord-012902-efprpk72	618	4	mortality	mortality	NN
cord-012902-efprpk72	618	5	are	be	VBP
cord-012902-efprpk72	618	6	increased	increase	VBN
cord-012902-efprpk72	618	7	in	in	IN
cord-012902-efprpk72	618	8	kidney	kidney	NN
cord-012902-efprpk72	618	9	transplant	transplant	NN
cord-012902-efprpk72	618	10	(	(	-LRB-
cord-012902-efprpk72	618	11	KT	KT	NNP
cord-012902-efprpk72	618	12	)	)	-RRB-
cord-012902-efprpk72	618	13	patients	patient	NNS
cord-012902-efprpk72	618	14	.	.	.
cord-012902-efprpk72	619	1	High	high	JJ
cord-012902-efprpk72	619	2	blood	blood	NN
cord-012902-efprpk72	619	3	pressure	pressure	NN
cord-012902-efprpk72	619	4	(	(	-LRB-
cord-012902-efprpk72	619	5	BP	BP	NNP
cord-012902-efprpk72	619	6	)	)	-RRB-
cord-012902-efprpk72	619	7	contributes	contribute	VBZ
cord-012902-efprpk72	619	8	significantly	significantly	RB
cord-012902-efprpk72	619	9	to	to	IN
cord-012902-efprpk72	619	10	this	this	DT
cord-012902-efprpk72	619	11	risk	risk	NN
cord-012902-efprpk72	619	12	and	and	CC
cord-012902-efprpk72	619	13	is	be	VBZ
cord-012902-efprpk72	619	14	associated	associate	VBN
cord-012902-efprpk72	619	15	with	with	IN
cord-012902-efprpk72	619	16	shortened	shorten	VBN
cord-012902-efprpk72	619	17	allograft	allograft	NN
cord-012902-efprpk72	619	18	survival	survival	NN
cord-012902-efprpk72	619	19	.	.	.
cord-012902-efprpk72	620	1	Dietary	dietary	JJ
cord-012902-efprpk72	620	2	salt	salt	NN
cord-012902-efprpk72	620	3	reduction	reduction	NN
cord-012902-efprpk72	620	4	is	be	VBZ
cord-012902-efprpk72	620	5	widely	widely	RB
cord-012902-efprpk72	620	6	recommended	recommend	VBN
cord-012902-efprpk72	620	7	as	as	IN
cord-012902-efprpk72	620	8	a	a	DT
cord-012902-efprpk72	620	9	strategy	strategy	NN
cord-012902-efprpk72	620	10	to	to	TO
cord-012902-efprpk72	620	11	lower	lower	VB
cord-012902-efprpk72	620	12	BP	BP	NNP
cord-012902-efprpk72	620	13	in	in	IN
cord-012902-efprpk72	620	14	the	the	DT
cord-012902-efprpk72	620	15	general	general	JJ
cord-012902-efprpk72	620	16	population	population	NN
cord-012902-efprpk72	620	17	and	and	CC
cord-012902-efprpk72	620	18	in	in	IN
cord-012902-efprpk72	620	19	chronic	chronic	JJ
cord-012902-efprpk72	620	20	kidney	kidney	NN
cord-012902-efprpk72	620	21	disease	disease	NN
cord-012902-efprpk72	620	22	.	.	.
cord-012902-efprpk72	621	1	Due	due	IN
cord-012902-efprpk72	621	2	to	to	IN
cord-012902-efprpk72	621	3	a	a	DT
cord-012902-efprpk72	621	4	lack	lack	NN
cord-012902-efprpk72	621	5	of	of	IN
cord-012902-efprpk72	621	6	evidence	evidence	NN
cord-012902-efprpk72	621	7	there	there	EX
cord-012902-efprpk72	621	8	is	be	VBZ
cord-012902-efprpk72	621	9	currently	currently	RB
cord-012902-efprpk72	621	10	no	no	DT
cord-012902-efprpk72	621	11	consensus	consensus	NN
cord-012902-efprpk72	621	12	on	on	IN
cord-012902-efprpk72	621	13	dietary	dietary	JJ
cord-012902-efprpk72	621	14	salt	salt	NN
cord-012902-efprpk72	621	15	restriction	restriction	NN
cord-012902-efprpk72	621	16	in	in	IN
cord-012902-efprpk72	621	17	KT	KT	NNP
cord-012902-efprpk72	621	18	patients	patient	NNS
cord-012902-efprpk72	621	19	.	.	.
cord-012902-efprpk72	622	1	Methods	method	NNS
cord-012902-efprpk72	622	2	:	:	:
cord-012902-efprpk72	623	1	Sixty	sixty	CD
cord-012902-efprpk72	623	2	stable	stable	JJ
cord-012902-efprpk72	623	3	KT	KT	NNP
cord-012902-efprpk72	623	4	patients	patient	NNS
cord-012902-efprpk72	623	5	,	,	,
cord-012902-efprpk72	623	6	≥6-months	≥6-months	NNP
cord-012902-efprpk72	623	7	posttransplantation	posttransplantation	NN
cord-012902-efprpk72	623	8	,	,	,
cord-012902-efprpk72	623	9	with	with	IN
cord-012902-efprpk72	623	10	BP	BP	NNP
cord-012902-efprpk72	623	11	≥120/80	≥120/80	NNP
cord-012902-efprpk72	623	12	mmHg	mmhg	NN
cord-012902-efprpk72	623	13	,	,	,
cord-012902-efprpk72	623	14	and	and	CC
cord-012902-efprpk72	623	15	sodium	sodium	NN
cord-012902-efprpk72	623	16	intake	intake	NN
cord-012902-efprpk72	623	17	≥80	≥80	NNP
cord-012902-efprpk72	623	18	mmol/24	mmol/24	NNP
cord-012902-efprpk72	623	19	h	h	NNP
cord-012902-efprpk72	623	20	,	,	,
cord-012902-efprpk72	623	21	were	be	VBD
cord-012902-efprpk72	623	22	randomised	randomise	VBN
cord-012902-efprpk72	623	23	in	in	IN
cord-012902-efprpk72	623	24	this	this	DT
cord-012902-efprpk72	623	25	parallel	parallel	NN
cord-012902-efprpk72	623	26	-	-	HYPH
cord-012902-efprpk72	623	27	designed	design	VBN
cord-012902-efprpk72	623	28	study	study	NN
cord-012902-efprpk72	623	29	to	to	TO
cord-012902-efprpk72	623	30	receive	receive	VB
cord-012902-efprpk72	623	31	either	either	CC
cord-012902-efprpk72	623	32	a	a	DT
cord-012902-efprpk72	623	33	regular	regular	JJ
cord-012902-efprpk72	623	34	-	-	HYPH
cord-012902-efprpk72	623	35	salt	salt	NN
cord-012902-efprpk72	623	36	diet	diet	NN
cord-012902-efprpk72	623	37	(	(	-LRB-
cord-012902-efprpk72	623	38	target	target	VB
cord-012902-efprpk72	623	39	150	150	CD
cord-012902-efprpk72	623	40	mmol/	mmol/	SYM
cord-012902-efprpk72	623	41	24	24	CD
cord-012902-efprpk72	623	42	h	h	NN
cord-012902-efprpk72	623	43	)	)	-RRB-
cord-012902-efprpk72	623	44	or	or	CC
cord-012902-efprpk72	623	45	low	low	JJ
cord-012902-efprpk72	623	46	-	-	HYPH
cord-012902-efprpk72	623	47	salt	salt	NN
cord-012902-efprpk72	623	48	diet	diet	NN
cord-012902-efprpk72	623	49	(	(	-LRB-
cord-012902-efprpk72	623	50	target	target	NN
cord-012902-efprpk72	623	51	80	80	CD
cord-012902-efprpk72	623	52	mmol/24	mmol/24	NNP
cord-012902-efprpk72	623	53	h	h	NN
cord-012902-efprpk72	623	54	)	)	-RRB-
cord-012902-efprpk72	623	55	for	for	IN
cord-012902-efprpk72	623	56	8-weeks	8-weeks	CD
cord-012902-efprpk72	623	57	.	.	.
cord-012902-efprpk72	624	1	The	the	DT
cord-012902-efprpk72	624	2	primary	primary	JJ
cord-012902-efprpk72	624	3	outcome	outcome	NN
cord-012902-efprpk72	624	4	measure	measure	NN
cord-012902-efprpk72	624	5	was	be	VBD
cord-012902-efprpk72	624	6	systolic	systolic	JJ
cord-012902-efprpk72	624	7	and	and	CC
cord-012902-efprpk72	624	8	diastolic	diastolic	JJ
cord-012902-efprpk72	624	9	BP	BP	NNP
cord-012902-efprpk72	624	10	.	.	.
cord-012902-efprpk72	625	1	Secondary	secondary	JJ
cord-012902-efprpk72	625	2	outcome	outcome	NN
cord-012902-efprpk72	625	3	measures	measure	NNS
cord-012902-efprpk72	625	4	included	include	VBD
cord-012902-efprpk72	625	5	24-h	24-h	JJ
cord-012902-efprpk72	625	6	ambulatory	ambulatory	JJ
cord-012902-efprpk72	625	7	BP	BP	NNP
cord-012902-efprpk72	625	8	(	(	-LRB-
cord-012902-efprpk72	625	9	ABP	ABP	NNP
cord-012902-efprpk72	625	10	)	)	-RRB-
cord-012902-efprpk72	625	11	and	and	CC
cord-012902-efprpk72	625	12	proteinuria	proteinuria	NN
cord-012902-efprpk72	625	13	.	.	.
cord-012902-efprpk72	626	1	Dietary	dietary	JJ
cord-012902-efprpk72	626	2	salt	salt	NN
cord-012902-efprpk72	626	3	intake	intake	NN
cord-012902-efprpk72	626	4	was	be	VBD
cord-012902-efprpk72	626	5	assessed	assess	VBN
cord-012902-efprpk72	626	6	by	by	IN
cord-012902-efprpk72	626	7	48-h	48-h	CD
cord-012902-efprpk72	626	8	urinary	urinary	JJ
cord-012902-efprpk72	626	9	sodium	sodium	NN
cord-012902-efprpk72	626	10	excretion	excretion	NN
cord-012902-efprpk72	626	11	.	.	.
cord-012902-efprpk72	627	1	Results	result	NNS
cord-012902-efprpk72	627	2	:	:	:
cord-012902-efprpk72	628	1	At	at	IN
cord-012902-efprpk72	628	2	baseline	baseline	NN
cord-012902-efprpk72	628	3	,	,	,
cord-012902-efprpk72	628	4	patients	patient	NNS
cord-012902-efprpk72	628	5	(	(	-LRB-
cord-012902-efprpk72	628	6	72	72	CD
cord-012902-efprpk72	628	7	%	%	NN
cord-012902-efprpk72	628	8	men	man	NNS
cord-012902-efprpk72	628	9	)	)	-RRB-
cord-012902-efprpk72	628	10	were	be	VBD
cord-012902-efprpk72	628	11	56	56	CD
cord-012902-efprpk72	628	12	±	±	CD
cord-012902-efprpk72	628	13	11	11	CD
cord-012902-efprpk72	628	14	years	year	NNS
cord-012902-efprpk72	628	15	with	with	IN
cord-012902-efprpk72	628	16	estimated	estimate	VBN
cord-012902-efprpk72	628	17	glomerular	glomerular	JJ
cord-012902-efprpk72	628	18	filtration	filtration	NN
cord-012902-efprpk72	628	19	rate	rate	NN
cord-012902-efprpk72	628	20	(	(	-LRB-
cord-012902-efprpk72	628	21	eGFR	egfr	NN
cord-012902-efprpk72	628	22	)	)	-RRB-
cord-012902-efprpk72	628	23	53	53	CD
cord-012902-efprpk72	628	24	±	±	CD
cord-012902-efprpk72	628	25	18	18	CD
cord-012902-efprpk72	628	26	mL	ml	NN
cord-012902-efprpk72	628	27	/	/	SYM
cord-012902-efprpk72	628	28	min/1.73	min/1.73	JJ
cord-012902-efprpk72	628	29	m	m	CD
cord-012902-efprpk72	628	30	2	2	CD
cord-012902-efprpk72	628	31	.	.	.
cord-012902-efprpk72	629	1	Mean	mean	JJ
cord-012902-efprpk72	629	2	urinary	urinary	JJ
cord-012902-efprpk72	629	3	sodium	sodium	NN
cord-012902-efprpk72	629	4	,	,	,
cord-012902-efprpk72	629	5	128	128	CD
cord-012902-efprpk72	629	6	±	±	CD
cord-012902-efprpk72	629	7	42	42	CD
cord-012902-efprpk72	629	8	mmol/	mmol/	.
cord-012902-efprpk72	630	1	24	24	CD
cord-012902-efprpk72	630	2	h	h	NN
cord-012902-efprpk72	630	3	,	,	,
cord-012902-efprpk72	630	4	mean	mean	VB
cord-012902-efprpk72	630	5	systolic	systolic	JJ
cord-012902-efprpk72	630	6	BP	BP	NNP
cord-012902-efprpk72	630	7	,	,	,
cord-012902-efprpk72	630	8	132	132	CD
cord-012902-efprpk72	630	9	±	±	CD
cord-012902-efprpk72	630	10	12	12	CD
cord-012902-efprpk72	630	11	mmHg	mmHg	NNS
cord-012902-efprpk72	630	12	,	,	,
cord-012902-efprpk72	630	13	and	and	CC
cord-012902-efprpk72	630	14	mean	mean	VB
cord-012902-efprpk72	631	1	diastolic	diastolic	JJ
cord-012902-efprpk72	631	2	BP	BP	NNP
cord-012902-efprpk72	631	3	,	,	,
cord-012902-efprpk72	632	1	77	77	CD
cord-012902-efprpk72	632	2	±	±	CD
cord-012902-efprpk72	632	3	10	10	CD
cord-012902-efprpk72	632	4	mmHg	mmHg	NNS
cord-012902-efprpk72	632	5	.	.	.
cord-012902-efprpk72	633	1	At	at	IN
cord-012902-efprpk72	633	2	the	the	DT
cord-012902-efprpk72	633	3	end	end	NN
cord-012902-efprpk72	633	4	of	of	IN
cord-012902-efprpk72	633	5	the	the	DT
cord-012902-efprpk72	633	6	intervention	intervention	NN
cord-012902-efprpk72	633	7	period	period	NN
cord-012902-efprpk72	633	8	sodium	sodium	NN
cord-012902-efprpk72	633	9	excretion	excretion	NN
cord-012902-efprpk72	633	10	was	be	VBD
cord-012902-efprpk72	633	11	significantly	significantly	RB
cord-012902-efprpk72	633	12	lower	low	JJR
cord-012902-efprpk72	633	13	in	in	IN
cord-012902-efprpk72	633	14	the	the	DT
cord-012902-efprpk72	633	15	low	low	JJ
cord-012902-efprpk72	633	16	-	-	HYPH
cord-012902-efprpk72	633	17	salt	salt	NN
cord-012902-efprpk72	633	18	group	group	NN
cord-012902-efprpk72	633	19	compared	compare	VBN
cord-012902-efprpk72	633	20	with	with	IN
cord-012902-efprpk72	633	21	the	the	DT
cord-012902-efprpk72	633	22	regular	regular	JJ
cord-012902-efprpk72	633	23	-	-	HYPH
cord-012902-efprpk72	633	24	salt	salt	NN
cord-012902-efprpk72	633	25	group	group	NN
cord-012902-efprpk72	633	26	(	(	-LRB-
cord-012902-efprpk72	633	27	90	90	CD
cord-012902-efprpk72	633	28	±	±	NNP
cord-012902-efprpk72	633	29	37	37	CD
cord-012902-efprpk72	633	30	vs.	vs.	NN
cord-012902-efprpk72	633	31	132	132	CD
cord-012902-efprpk72	633	32	±	±	CD
cord-012902-efprpk72	633	33	51	51	CD
cord-012902-efprpk72	633	34	mmol/24	mmol/24	NNP
cord-012902-efprpk72	633	35	h	h	NN
cord-012902-efprpk72	633	36	;	;	:
cord-012902-efprpk72	633	37	adjusted	adjust	VBN
cord-012902-efprpk72	633	38	mean	mean	JJ
cord-012902-efprpk72	633	39	difference	difference	NN
cord-012902-efprpk72	633	40	,	,	,
cord-012902-efprpk72	633	41	−36	−36	NNP
cord-012902-efprpk72	633	42	[	[	-LRB-
cord-012902-efprpk72	633	43	95	95	CD
cord-012902-efprpk72	633	44	%	%	NN
cord-012902-efprpk72	633	45	CI	CI	NNP
cord-012902-efprpk72	633	46	,	,	,
cord-012902-efprpk72	633	47	−59	−59	NNP
cord-012902-efprpk72	633	48	to	to	IN
cord-012902-efprpk72	633	49	−14	−14	NNP
cord-012902-efprpk72	633	50	]	]	-RRB-
cord-012902-efprpk72	633	51	mmol/24	mmol/24	NNP
cord-012902-efprpk72	633	52	h	h	NN
cord-012902-efprpk72	633	53	;	;	:
cord-012902-efprpk72	633	54	P	p	NN
cord-012902-efprpk72	633	55	=	=	SYM
cord-012902-efprpk72	633	56	0.002	0.002	CD
cord-012902-efprpk72	633	57	)	)	-RRB-
cord-012902-efprpk72	633	58	.	.	.
cord-012902-efprpk72	634	1	We	-PRON-	PRP
cord-012902-efprpk72	634	2	found	find	VBD
cord-012902-efprpk72	634	3	no	no	DT
cord-012902-efprpk72	634	4	difference	difference	NN
cord-012902-efprpk72	634	5	in	in	IN
cord-012902-efprpk72	634	6	systolic	systolic	JJ
cord-012902-efprpk72	634	7	BP	BP	NNP
cord-012902-efprpk72	634	8	(	(	-LRB-
cord-012902-efprpk72	634	9	adjusted	adjust	VBN
cord-012902-efprpk72	634	10	mean	mean	JJ
cord-012902-efprpk72	634	11	difference	difference	NN
cord-012902-efprpk72	634	12	,	,	,
cord-012902-efprpk72	634	13	−2	−2	NNP
cord-012902-efprpk72	635	1	[	[	-LRB-
cord-012902-efprpk72	635	2	95	95	CD
cord-012902-efprpk72	635	3	%	%	NN
cord-012902-efprpk72	635	4	CI	CI	NNP
cord-012902-efprpk72	635	5	,	,	,
cord-012902-efprpk72	635	6	−12	−12	NNP
cord-012902-efprpk72	635	7	to	to	IN
cord-012902-efprpk72	635	8	9	9	CD
cord-012902-efprpk72	635	9	]	]	-RRB-
cord-012902-efprpk72	635	10	mmHg	mmHg	NNS
cord-012902-efprpk72	635	11	;	;	:
cord-012902-efprpk72	635	12	P	p	NN
cord-012902-efprpk72	635	13	=	=	SYM
cord-012902-efprpk72	635	14	0.750	0.750	CD
cord-012902-efprpk72	635	15	)	)	-RRB-
cord-012902-efprpk72	636	1	,	,	,
cord-012902-efprpk72	636	2	diastolic	diastolic	JJ
cord-012902-efprpk72	636	3	BP	BP	NNP
cord-012902-efprpk72	636	4	(	(	-LRB-
cord-012902-efprpk72	636	5	adjusted	adjust	VBN
cord-012902-efprpk72	636	6	mean	mean	JJ
cord-012902-efprpk72	636	7	difference	difference	NN
cord-012902-efprpk72	636	8	,	,	,
cord-012902-efprpk72	636	9	0	0	NFP
cord-012902-efprpk72	636	10	[	[	-LRB-
cord-012902-efprpk72	636	11	95	95	CD
cord-012902-efprpk72	636	12	%	%	NN
cord-012902-efprpk72	636	13	CI	CI	NNP
cord-012902-efprpk72	636	14	,	,	,
cord-012902-efprpk72	636	15	−4	−4	CD
cord-012902-efprpk72	636	16	to	to	IN
cord-012902-efprpk72	636	17	4	4	CD
cord-012902-efprpk72	636	18	]	]	-RRB-
cord-012902-efprpk72	636	19	mmHg	mmHg	NNS
cord-012902-efprpk72	636	20	;	;	:
cord-012902-efprpk72	636	21	P	p	NN
cord-012902-efprpk72	636	22	=	=	SYM
cord-012902-efprpk72	636	23	0.887	0.887	CD
cord-012902-efprpk72	636	24	)	)	-RRB-
cord-012902-efprpk72	636	25	,	,	,
cord-012902-efprpk72	636	26	24-h	24-h	JJ
cord-012902-efprpk72	636	27	systolic	systolic	JJ
cord-012902-efprpk72	636	28	ABP	ABP	NNP
cord-012902-efprpk72	636	29	(	(	-LRB-
cord-012902-efprpk72	636	30	adjusted	adjust	VBN
cord-012902-efprpk72	636	31	mean	mean	JJ
cord-012902-efprpk72	636	32	difference	difference	NN
cord-012902-efprpk72	636	33	,	,	,
cord-012902-efprpk72	636	34	−3	−3	NN
cord-012902-efprpk72	637	1	[	[	-LRB-
cord-012902-efprpk72	637	2	95	95	CD
cord-012902-efprpk72	637	3	%	%	NN
cord-012902-efprpk72	637	4	CI	CI	NNP
cord-012902-efprpk72	637	5	,	,	,
cord-012902-efprpk72	637	6	−9	−9	NNP
cord-012902-efprpk72	637	7	to	to	IN
cord-012902-efprpk72	637	8	2	2	CD
cord-012902-efprpk72	637	9	]	]	-RRB-
cord-012902-efprpk72	637	10	mmHg	mmHg	NNS
cord-012902-efprpk72	637	11	;	;	:
cord-012902-efprpk72	637	12	P	p	NN
cord-012902-efprpk72	637	13	=	=	SYM
cord-012902-efprpk72	637	14	0.213	0.213	CD
cord-012902-efprpk72	637	15	)	)	-RRB-
cord-012902-efprpk72	637	16	or	or	CC
cord-012902-efprpk72	637	17	24-h	24-h	JJ
cord-012902-efprpk72	637	18	diastolic	diastolic	JJ
cord-012902-efprpk72	637	19	ABP	ABP	NNP
cord-012902-efprpk72	637	20	(	(	-LRB-
cord-012902-efprpk72	637	21	adjusted	adjust	VBN
cord-012902-efprpk72	637	22	mean	mean	JJ
cord-012902-efprpk72	637	23	difference	difference	NN
cord-012902-efprpk72	637	24	,	,	,
cord-012902-efprpk72	637	25	−2	−2	NNP
cord-012902-efprpk72	638	1	[	[	-LRB-
cord-012902-efprpk72	638	2	95	95	CD
cord-012902-efprpk72	638	3	%	%	NN
cord-012902-efprpk72	638	4	CI	CI	NNP
cord-012902-efprpk72	638	5	,	,	,
cord-012902-efprpk72	638	6	−5	−5	NNP
cord-012902-efprpk72	638	7	to	to	IN
cord-012902-efprpk72	638	8	1	1	CD
cord-012902-efprpk72	638	9	]	]	-RRB-
cord-012902-efprpk72	638	10	mmHg	mmHg	NNS
cord-012902-efprpk72	638	11	;	;	:
cord-012902-efprpk72	638	12	P	p	NN
cord-012902-efprpk72	638	13	=	=	SYM
cord-012902-efprpk72	638	14	0.267	0.267	CD
cord-012902-efprpk72	638	15	)	)	-RRB-
cord-012902-efprpk72	638	16	.	.	.
cord-012902-efprpk72	639	1	There	there	EX
cord-012902-efprpk72	639	2	was	be	VBD
cord-012902-efprpk72	639	3	no	no	DT
cord-012902-efprpk72	639	4	significant	significant	JJ
cord-012902-efprpk72	639	5	effect	effect	NN
cord-012902-efprpk72	639	6	on	on	IN
cord-012902-efprpk72	639	7	proteinuria	proteinuria	NN
cord-012902-efprpk72	639	8	or	or	CC
cord-012902-efprpk72	639	9	eGFR.Conclusions	egfr.conclusion	NNS
cord-012902-efprpk72	639	10	:	:	:
cord-012902-efprpk72	640	1	In	in	IN
cord-012902-efprpk72	640	2	this	this	DT
cord-012902-efprpk72	640	3	study	study	NN
cord-012902-efprpk72	640	4	baseline	baseline	JJ
cord-012902-efprpk72	640	5	urinary	urinary	JJ
cord-012902-efprpk72	640	6	sodium	sodium	NN
cord-012902-efprpk72	640	7	was	be	VBD
cord-012902-efprpk72	640	8	lower	low	JJR
cord-012902-efprpk72	640	9	than	than	IN
cord-012902-efprpk72	640	10	expected	expect	VBN
cord-012902-efprpk72	640	11	and	and	CC
cord-012902-efprpk72	640	12	baseline	baseline	JJ
cord-012902-efprpk72	641	1	BP	BP	NNP
cord-012902-efprpk72	641	2	was	be	VBD
cord-012902-efprpk72	641	3	well	well	RB
cord-012902-efprpk72	641	4	-	-	HYPH
cord-012902-efprpk72	641	5	controlled	control	VBN
cord-012902-efprpk72	641	6	.	.	.
cord-012902-efprpk72	642	1	Reducing	reduce	VBG
cord-012902-efprpk72	642	2	dietary	dietary	JJ
cord-012902-efprpk72	642	3	salt	salt	NN
cord-012902-efprpk72	642	4	by	by	IN
cord-012902-efprpk72	642	5	2g	2g	CD
cord-012902-efprpk72	642	6	/	/	SYM
cord-012902-efprpk72	642	7	day	day	NN
cord-012902-efprpk72	642	8	did	do	VBD
cord-012902-efprpk72	642	9	not	not	RB
cord-012902-efprpk72	642	10	have	have	VB
cord-012902-efprpk72	642	11	a	a	DT
cord-012902-efprpk72	642	12	significant	significant	JJ
cord-012902-efprpk72	642	13	effect	effect	NN
cord-012902-efprpk72	642	14	on	on	IN
cord-012902-efprpk72	642	15	office	office	NN
cord-012902-efprpk72	642	16	BP	BP	NNP
cord-012902-efprpk72	642	17	readings	reading	NNS
cord-012902-efprpk72	642	18	.	.	.
cord-012902-efprpk72	643	1	Clinical	clinical	JJ
cord-012902-efprpk72	643	2	Trial	Trial	NNP
cord-012902-efprpk72	643	3	Registry	Registry	NNP
cord-012902-efprpk72	643	4	:	:	:
cord-012902-efprpk72	643	5	NCT03373500	nct03373500	UH
cord-012902-efprpk72	643	6	,	,	,
cord-012902-efprpk72	643	7	https://Clinica	https://clinica	DT
cord-012902-efprpk72	643	8	lTrials.gov	lTrials.gov	NNP
cord-012902-efprpk72	643	9	P-20	P-20	NNP
cord-012902-efprpk72	644	1	The	the	DT
cord-012902-efprpk72	644	2	effect	effect	NN
cord-012902-efprpk72	644	3	of	of	IN
cord-012902-efprpk72	644	4	plant	plant	NN
cord-012902-efprpk72	644	5	-	-	HYPH
cord-012902-efprpk72	644	6	based	base	VBN
cord-012902-efprpk72	644	7	diets	diet	NNS
cord-012902-efprpk72	644	8	on	on	IN
cord-012902-efprpk72	644	9	blood	blood	NN
cord-012902-efprpk72	644	10	pressure	pressure	NN
cord-012902-efprpk72	644	11	:	:	:
cord-012902-efprpk72	644	12	a	a	DT
cord-012902-efprpk72	644	13	systematic	systematic	JJ
cord-012902-efprpk72	644	14	review	review	NN
cord-012902-efprpk72	644	15	and	and	CC
cord-012902-efprpk72	644	16	meta	meta	NNP
cord-012902-efprpk72	644	17	-	-	HYPH
cord-012902-efprpk72	644	18	analysis	analysis	NN
cord-012902-efprpk72	644	19	of	of	IN
cord-012902-efprpk72	644	20	controlled	control	VBN
cord-012902-efprpk72	644	21	clinical	clinical	JJ
cord-012902-efprpk72	644	22	trials	trial	NNS
cord-012902-efprpk72	644	23	Joshua	Joshua	NNP
cord-012902-efprpk72	644	24	Gibbs	Gibbs	NNP
cord-012902-efprpk72	644	25	1	1	CD
cord-012902-efprpk72	644	26	,	,	,
cord-012902-efprpk72	644	27	Eleanor	Eleanor	NNP
cord-012902-efprpk72	644	28	Gaskin	Gaskin	NNP
cord-012902-efprpk72	644	29	1	1	CD
cord-012902-efprpk72	644	30	,	,	,
cord-012902-efprpk72	644	31	Chen	Chen	NNP
cord-012902-efprpk72	644	32	Ji	Ji	NNP
cord-012902-efprpk72	644	33	1	1	CD
cord-012902-efprpk72	644	34	,	,	,
cord-012902-efprpk72	644	35	Michelle	Michelle	NNP
cord-012902-efprpk72	644	36	Miller	Miller	NNP
cord-012902-efprpk72	644	37	1	1	CD
cord-012902-efprpk72	644	38	,	,	,
cord-012902-efprpk72	644	39	Francesco	Francesco	NNP
cord-012902-efprpk72	644	40	Cappuccio	Cappuccio	NNP
cord-012902-efprpk72	644	41	1	1	CD