id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-335310-61wibso4	Chen, Hui-Wen	Synthetic virus-like particles prepared via protein corona formation enable effective vaccination in an avian model of coronavirus infection	2016-08-15		.txt	text/plain	5482	264	40	Herein, a facile approach to formulate synthetic virus-like particles (sVLPs) is demonstrated by exploiting the phenomenon of protein corona formation induced by the high-energy surfaces of synthetic nanoparticles. As compared to inoculation with free proteins, vaccination with the sVLPs showed enhanced lymphatic antigen delivery, stronger antibody titers, increased splenic T-cell response, and reduced infection-associated symptoms in an avian model of coronavirus infection. Comparison to a commercial whole inactivated virus vaccine also showed evidence of superior antiviral protection by the sVLPs. The study demonstrates a simple yet robust method in bridging viral antigens with synthetic nanoparticles for improved vaccine application; it has practical implications in the management of human viral infections as well as in animal agriculture. In the present study, vaccination with the sVLPs resulted in enhanced humoral and cellular immune responses, improving protection against an avian model of coronavirus infection as compared to free protein antigens and a commercial WIV vaccine.	./cache/cord-335310-61wibso4.txt	./txt/cord-335310-61wibso4.txt