id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001677-p6ikd8ns	Hansra, Satyender	Exploration of New Sites in Adenovirus Hexon for Foreign Peptides Insertion	2015-05-29		.txt	text/plain	2912	168	49	To this end, we utilized sites in the hexon hypervariable region (HVR) 7, 8 and 9 to display a 15-mer peptide containing the main neutralizing epitope of porcine reproductive and respiratory syndrome virus. In this study, we explored different sites in HVRs 7, 8 and 9 of hAd5 hexon for the insertion of a peptide corresponding to the porcine reproductive and respiratory syndrome virus (PRRSV) main neutralizing epitope B [19] of the GP5 protein. In the current study, we find a new site in HVR7 for incorporation of foreign peptide into hAd5 hexon, and determine that the peptide was also exposed on the virion surface making it readily accessible for antibody binding and be potentially useful for vaccination. Herein, we report a novel adenovirus vector (Ad5HVR7epB) with the insertion of the PRRSV main neutralizing epitope B in 3 different HVR regions of the major capsid protein hexon.	./cache/cord-001677-p6ikd8ns.txt	./txt/cord-001677-p6ikd8ns.txt