id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-283667-jqlz7yt8	Katz, Sophie E.	Pediatric Community-Acquired Pneumonia in the United States Changing Epidemiology, Diagnostic and Therapeutic Challenges, and Areas for Future Research	2018-03-31		.txt	text/plain	5254	306	33	That study used traditional culture methods, pneumolysin-based polymerase chain reaction (PCR) assays, viral direct fluorescent antibody tests, and serologic tests for viruses, Mycoplasma spp, and Chlamydia spp to identify pathogens in 154 hospitalized children with radiographically confirmed lower respiratory infections at a single institution. A majority of patients (60%) were noted to have infection with typical respiratory bacteria (most commonly, Streptococcus pneumoniae, detected in 73% of children with documented bacterial disease), with viruses identified in 45% of children. The multicenter Centers for Disease Control and Prevention (CDC) Etiology of Pneumonia in the Community (EPIC) Study was a prospective, population-based surveillance study of greater than 2300 pediatric CAP hospitalizations in the United States conducted from 2010 to 2012. To evaluate the impact of CRP in the etiologic diagnosis of pneumonia, a meta-analysis of 8 studies with more than 1200 children with viral or bacterial causes of CAP demonstrated that CRP levels greater than or equal to 40 mg/L to 60 mg/L were associated with only a 64% positive predictive value for identifying children with bacterial pneumonia.	./cache/cord-283667-jqlz7yt8.txt	./txt/cord-283667-jqlz7yt8.txt