id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-006331-s2qf98lj	Spiridonova, V. A.	Molecular recognition elements: DNA/RNA-aptamers to proteins	2010-05-23		.txt	text/plain	7144	412	57	After 16 rounds of selection from the 2' amino modified RNA library the isolated aptamers formed a complex with FVIIa characterized by the K d value of 11.3 ± 1.3 nM. performed RNA selection to FIXa; after eight rounds of selection they found an aptamer, which bound to FIXa with the K d value of 0.65 ± 0.2 nM and exhibited 5000 fold higher affinity to FIXa compared with FVIIa, FXa, FXIa and activated protein C [20] . These aptamers formed a complex with ΔNS3 with the K d value of 10 nM, caused 90% inhibition of protease activity of the ΔNS3 peptide and full sized NS3 bound to a maltose binding protein (MBP NS3). Four teen rounds of selection yielded the RNA aptamer, exhibiting high affinity binding to p50 and inhibition of NF kB binding to DNA by preventing protein dimerization [91] .	./cache/cord-006331-s2qf98lj.txt	./txt/cord-006331-s2qf98lj.txt