id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-014852-6friw2ek	Chumakov, S. P.	Organization and regulation of nucleocytoplasmic transport	2010-04-24		.txt	text/plain	9153	496	50	Nuclear RanGTP is capable of releasing the target protein from an imported complex upon binding with karyo pherins. The main properties that allow karyopherins to ensure efficient nuclear transport are their capabilities of binding with a target protein (directly or through an adaptor) and interacting with Nup or RanGTP [12] . Structural studies of karyopherin β1 in complex with the phenylalanine-glycine (FG) repeat contain ing fragment of yeast Nup showed that the interactions between the two proteins are mostly hydrophobic and involve the phenylalanine residues of Nup. The karyo pherin molecule forms two hydrophobic pockets: between HEAT repeats 5 and 6 and between repeats 6 and 7. NTF2 interacts with RanGDP, which is the main cytoplasmic form of Ran. The NTF2-RanGDP complex is transferred into the nucleus, which is due to the ability of NTF2 to interact with low affinity with FG containing Nup proteins, as karyopherins do. One of the key steps of nuclear transport is the interaction of importins and exportins with the NLS or NES of a target protein.	./cache/cord-014852-6friw2ek.txt	./txt/cord-014852-6friw2ek.txt