id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-020788-a33vcapl	Gottardi, Cara J.	Signals and Mechanisms of Sorting in Epithelial Polarity	2008-05-22		.txt	text/plain	13900	598	39	At the electron-microscopic level, one of the most apparent and fundamental features of this cell type is its polarized organization of intracellular organelles and its structurally and compositionally distinct lumenal (apical) and serosal (basolateral) plasma-membrane domains. As noted above, in hepatocytes all apical proteins studied to date make use of this indirect pathway for apical delivery (Bartles et al., 1987) , while cell lines derived from intestine and kidney can employ both routes for surface delivery (Matter et al., 1990; Casanovaet al., 1991; Low et al., 1991) While the details of the routes have been determined for a number of sorting pathways, the molecular signals and recognition components which control each of them are not well understood. The observation that the influenza and vesicular stomatitis viruses bud from opposite surface domains of polarized MDCK cells (Madin Darby Canine Kidney) (Rodriguez-Boulan and Sabatini, 1978) spawned an extensive search in which chimeric and deletion analyses were applied to the problem of identifying the underlying apical and basolateral sorting signals (reviewed in Caplan and Matlin, 1989) .	./cache/cord-020788-a33vcapl.txt	./txt/cord-020788-a33vcapl.txt