id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-021393-9loesliv	Meade, H.M.	EXPRESSION OF RECOMBINANT PROTEINS IN THE MILK OF TRANSGENIC ANIMALS	2007-09-02		.txt	text/plain	8080	416	48	To date (1997) , probably more than 50 proteins have been expressed in the milk of transgenic mice, rats, rabbits, goats, sheep, pigs, and dairy cows. Transgenes containing sequences of several milk protein genes, reviewed by Maga and Murray (1995) and Echelard (1996) , have been used to direct the expression of exogenous proteins to the lactating mammary gland. Regulatory sequences from several milk-specific genes have been isolated and tested in transgenic animals: ovine ~-lactoglobulin; murine, rat, and rabbit whey acidic protein (WAP); bovine ~-sl casein; rat, rabbit, and goat f~-casein; and guinea pig, ovine, caprine, and bovine ~-lactalbumin. A 17.2 kbp region located upstream of the rabbit WAP gene directs high level expression of a functional human protein variant in transgenic mouse milk High level production of human growth hormone in the milk of transgenic mice: The upstream region of the whey acidic protein (WAP) gene targets transgene expression to the mammary gland	./cache/cord-021393-9loesliv.txt	./txt/cord-021393-9loesliv.txt