id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-022235-6ircruag	Pugsley, Anthony P.	Later stages in the eukaryotic secretory pathway	2012-12-02		.txt	text/plain	15217	667	52	Microinjected antibodies recognizing the C-terminal, cytoplasmic tails of plasma membrane proteins can prevent their trans port to the cell surface (25, 590) , but this is probably due to antibodyinduced changes in protein conformation which make the protein incom petent for transport along the secretory pathway, rather than to inhibition of receptor-secretory protein interactions. (545) found that pro-a-factor processing was blocked by sec mutations, which prevented protein movement through the Golgi, and that mature α factor was normally present in secretory vesicles en route to the cell surface. The TGN is the most acidic Golgi compartment, although the pH is almost certainly not as low as in secretory granules (823) or in lysosomal sorting vesicles, in which low pH causes the dissociation of lysosomal proteins from the mannose-6-phosphate receptor (577) (see Section V.G.5). (1022) also observed the transient accumulation of one of these enzymes in coated vesicles, which, they proposed, are specifically involved in the sorting of lysosomal proteins from the secretory pathway.	./cache/cord-022235-6ircruag.txt	./txt/cord-022235-6ircruag.txt