id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-029747-8f463wz0	Viedma-Poyatos, Álvaro	Type III intermediate filaments as targets and effectors of electrophiles and oxidants	2020-07-17		.txt	text/plain	12680	612	34	The type III IFs, vimentin, desmin, peripherin and glial fibrillary acidic protein (GFAP), are targets for diverse modifications by oxidants and electrophiles, for which their conserved cysteine residue emerges as a hot spot. Appearance of carbonyl groups on proteins can occur by several mechanisms, including oxidation of amino acid lateral chains, oxidative deamination or formation of certain adducts with compounds that retain a free carbonyl group, as in some types of lipoxidation, like Michael addition of cyPG or of HNE, or after glycation or glycoxidation. Early studies using cytoskeleton preparations from several cell types subjected to oxidative in vitro crosslinking with Cu 2+ -phenanthroline showed the formation of homo-and heterodimers of either vimentin and desmin or vimentin and GFAP, which led to propose that both proteins were present in hybrid filaments [85, 86] .	./cache/cord-029747-8f463wz0.txt	./txt/cord-029747-8f463wz0.txt