id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-034191-qqb2knmo	Alayi, Tchilabalo D.	Tandem Mass Tag-Based Serum Proteome Profiling for Biomarker Discovery in Young Duchenne Muscular Dystrophy Boys	2020-10-06		.txt	text/plain	8942	439	48	In this study, we sought to optimize and standardize a serum processing workflow in combination with tandem mass tag (TMT) multiplexing strategy to systematically survey the serum proteome of young untreated DMD boys and agematched healthy controls and identify biomarkers associated in the early stages of the disease. Serum samples from 4 year-old glucocorticoid naive DMD patients (n = 9) and age-matched healthy controls (n = 9) were processed for proteome profiling using our standardized multiplexing TMT-based mass spectrometry method described above. As expected, a large number of identified biomarkers (50%) that were found to be elevated in sera of these young DMD boys relative to the healthy controls were of muscle origin based on Gene Ontology molecular function annotations ( Figure S2 ) and information collected using Mass Spectrometry Data Analysis tools.	./cache/cord-034191-qqb2knmo.txt	./txt/cord-034191-qqb2knmo.txt