id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-196265-mvnkkcow	M'esz'aros, B'alint	Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implications	2020-04-21		.txt	text/plain	12653	666	47	We examined the sequences of ACE2 and integrins with the Eukaryotic Linear Motif resource, ELM, and were presented with candidate short linear motifs (SLiMs) in their short, unstructured, cytosolic tails with potential roles in endocytosis, membrane dynamics, autophagy, cytoskeleton and cell signalling. Proximity-based mass spectrometry on the MHV replication complex further revealed that the RTC environment repurposes components from the host autophagy, vesicular trafficking and translation machineries (V'kovski et al., 2019) In the present work, we identify a set of conserved SLiM candidates in the ACE2 and integrin proteins, which are likely to act in the cell entry system of SARS-CoV-2. The C-terminal tail of both subunits share a high degree of sequence similarity, and similarly to ACE2, contain several known and candidate SLiMs (see Table 1 and Figure 6 ) that propagate signals in the cytoplasm and regulate integrin activity not just through intracellular pathways, but also changing the structural state of the ectodomains determining ligand binding capacity (Anthis and Campbell, 2011) .	./cache/cord-196265-mvnkkcow.txt	./txt/cord-196265-mvnkkcow.txt