id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-279463-bli8hwda	Lipp, Joachim	The membrane-spanning segment of invariant chain (Iγ) contains a potentially cleavable signal sequence	1986-09-26		.txt	text/plain	6276	367	62	As type II membrane proteins contain only a single stretch of hydrophobic amino acid residues, this might function as a signal for membrane insertion as well as a membrane anchor (Markoff et al., 1984; Spiess and Lodish, 1986) . plycat is an in-frame fusion between the 5' region of ly encoding the cytoplas, mic, membrane-spanning segment plus 12 amino acids of the exoplasmic portion of ly and the gene encoding the cytoplasmic protein chloramphenicol acetyltransferase (CAT). After protease digestion in the presence of microsomal membranes, lyCAT* is reduced in molecular weight by about 2 kd, suggesting that it exposes 20-30 amino acid residues on the cytoplasmic side ( Figure 3 , lanes 2 and 3). This signal sequence is located in the amino-terminal half of the membrane-spanning segment, and it is cleaved when the preceding cytoplasmic domain is removed.	./cache/cord-279463-bli8hwda.txt	./txt/cord-279463-bli8hwda.txt