id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-287410-boxxlopy	Devi, Arpita	In silico designing of multi-epitope vaccine construct against human coronavirus infections	2020-08-10		.txt	text/plain	7189	446	60	Band T-cell epitopes of the spike proteins have been predicted and designed into a multi-epitope vaccine construct. To predict the probable immune response of the designed multi-epitope vaccine construct in human immune system, in silico immune simulations were conducted using the C-ImmSim server (http://150.146.2.1/C-IMMSIM/index.php) (Rapin et al., 2010) . C-ImmSim is a novel in silico approach for the study of the mammalian immune system The tool is a combination of a mesoscopic scale simulator of the immune system with machine learning techniques for molecular-level predictions of major histocompatibility complex (MHC)-peptide-binding interactions, linear B-cell epitope discovery, and protein-protein potential estimation. The antigenicity of the vaccine construct including the adjuvant sequence and His-tag was predicted by the VaxiJen 2.0 server to be 0.6452 with a bacteria model at a threshold of 0.4.	./cache/cord-287410-boxxlopy.txt	./txt/cord-287410-boxxlopy.txt