id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-302490-em1tiz7s	Cañadas, Olga	Lipid–Protein and Protein–Protein Interactions in the Pulmonary Surfactant System and Their Role in Lung Homeostasis	2020-05-25		.txt	text/plain	16675	733	32	To fulfill this crucial role, alveolar epithelial type II cells (AE2C) secrete pulmonary surfactant, a lipid-protein complex that forms a surface active film at the respiratory interface, allowing its stability and avoiding alveolar collapse during expiration [3, 4] . On the other hand, the structure of surfactant aggregates does not influence its uptake by AMs [169] , and although SP-D is able to bind to the surface of these cells to modulate inflammation, the homeostasis/immune roles of the protein seem to be independently regulated [94] . Surfactant proteins and lipids have been shown to provide immune protection against respiratory pathogens, both directly by limiting inflammation and promoting pathogen clearance, and indirectly by activating molecular and cellular mechanisms that contribute to restore lung homeostasis [15, [181] [182] [183] . Anionic pulmonary surfactant phospholipids inhibit inflammatory responses from alveolar macrophages and U937 cells by binding the lipopolysaccharide-interacting proteins CD14 and MD-2	./cache/cord-302490-em1tiz7s.txt	./txt/cord-302490-em1tiz7s.txt