id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-315984-5gbhobw8	Isaacson, Marisa K.	Ubiquitination, Ubiquitin-like Modifiers, and Deubiquitination in Viral Infection	2009-06-18		.txt	text/plain	8898	467	44	HPV infection also leads to degradation of the retinoblastoma protein pRb through the ubiquitin-proteasome pathway (reviewed in Mammas et al., 2008) , mediated via the HPV E7-protein-induced generation of an E3 ligase complex consisting of the Cullin2 Processed ubiquitin (Ub) or ubiquitin-like modifier (Ubl) is activated with ATP by an E1 ubiquitin-activating enzyme (1) and then transferred to an E2 ubiquitin-conjugating enzyme (2). Herpes simplex virus 1 (HSV-1) infected cell protein 0 (ICP0) is a E3 ubiquitin ligase that induces polyubiquitination and degradation of a variety of proteins, including the promyelocytic leukemia (PML) protein, Sp100 (another component of PML nuclear bodies) (Chelbi-Alix and de Boutell et al., 2002) , cyclin D3 (Van Sant et al., 2001; Hagglund et al., 2002) , p53, and the cellular deubiquitinating enzyme USP7.	./cache/cord-315984-5gbhobw8.txt	./txt/cord-315984-5gbhobw8.txt