id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-319722-udqu5jub	Ng, Eddy W. Y.	Advances in MALDI Mass Spectrometry in Clinical Diagnostic Applications	2013-04-07		.txt	text/plain	12514	594	42	One commonly used approach for identification of disease-specific biomarkers is to compare the quantitative biomolecule profiles of plasma/serum specimens from the patients with the target disease and control subjects without the disease. For example, after immunoprecipitation of amyloid-beta peptides from the cerebral spinal fluid, different amyloid-beta isoforms as well as their corresponding stable-isotope labeled internal standards appear as individual peaks of expected m/z values in a MALDI-TOF mass spectrum, and their quantities can be measured with high accuracy with intra-assay CVs <10% [33] . Surface-enhanced laser desorption/ionization TOF mass spectrometry (SELDI-TOF MS) is a variant of MALDI-TOF MS, and is mainly designed for quantitative analysis of proteins in biological samples. It may be because SELDI-TOF MS was the first high-throughput technology that allowed quantitative profiling and comparison of the serum/plasma proteins in a large number of patient samples within a very short period of time.	./cache/cord-319722-udqu5jub.txt	./txt/cord-319722-udqu5jub.txt