id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-320092-0qnvydux	Ehsani, Sepehr	COVID-19 and iron dysregulation: distant sequence similarity between hepcidin and the novel coronavirus spike glycoprotein	2020-10-16		.txt	text/plain	7536	406	45	An implication of this preliminary observation is to suggest a potential route of investigation in the coronavirus research field making use of an already-established literature on the interplay of local and systemic iron regulation, cytokine-mediated inflammatory processes, respiratory infections and the hepcidin protein. c The position of the disulfide bonds in the sequence of the mature human hepcidin is illustrated along with the potential palmitoylation residues (ten cysteines) of the cytoplasmic tail of the SARS-CoV-2 spike protein. If the sequence similarity reported here is actually playing a significant role at the cellular level, could it be that, although the cellular localizations appear to be different based on current knowledge, the SARS-CoV-2 spike protein cytoplasmic tail can partly mimic the structure of hepcidin and interact with ferroportin? In addition, a notyet-fully-established link of relevance here is the observations of a Kawasaki-disease-like systemic vasculitis syndrome in children infected with the novel Fig. 3 Summary of salient facets of coronavirus spike protein and human hepcidin biology.	./cache/cord-320092-0qnvydux.txt	./txt/cord-320092-0qnvydux.txt