id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-350423-yaeduwvb	James, Claire D.	Viral Interactions with PDZ Domain-Containing Proteins—An Oncogenic Trait?	2016-01-18		.txt	text/plain	10615	433	39	Many of the human viruses with oncogenic capabilities, either in their natural host or in experimental systems (hepatitis B and C, human T cell leukaemia virus type 1, Kaposi sarcoma herpesvirus, human immunodeficiency virus, high-risk human papillomaviruses and adenovirus type 9), encode in their limited genome the ability to target cellular proteins containing PSD95/ DLG/ZO-1 (PDZ) interaction modules. Survival of rabies infected neuronal cells is associated with the ability of the viral envelope G protein to interact with the PDZ domain-containing serine threonine kinase MAST2, leading to the disruption of the MAST2-PTEN complex that is intimately involved in the inhibition of neuronal survival [11] . Therefore, in HPV infections the tumour suppressor forms of DLG that are involved in the negative regulation of cell proliferation might be the initial target of the E6 PBM, but during disease progression DLG1, either through mislocalization and/or the stabilization of specific pools, acquires oncogenic functions mediated by interaction with E6 [3, 127] .	./cache/cord-350423-yaeduwvb.txt	./txt/cord-350423-yaeduwvb.txt