id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-355377-b0rcg3rt	van der Vlag, R.	Analytical Methods in Protein-Templated Dynamic Combinatorial Chemistry	2017-06-29		.txt	text/plain	9842	518	53	Protein-templated dynamic combinatorial chemistry (DCC) has emerged as a powerful method to identify new inhibitors given that it enables the protein to select its own best binder(s) from a library of interconverting compounds. Both DCLs showed a very clear amplification of acylhydrazones: t-butylphenyl and thiophenyl acylhydrazones 4-5c and 4-5g were amplified in presence of hGST P1-1 and SjGST, Scheme 3 Generation of acylhydrazone-based dynamic combinatorial libraries of (A) aldehydes 4 or 6 and hydrazides 5a-j. The protein concentration can be very low, but 1 H-waterLOGSY 21 can be limited by the exchange kinetics of the reversibly formed protein-ligand complexes and might still suffer from overlapping signals, especially for large DCLs. In 2013, the same group introduced a competition-based 1 H-NMR method to screen binders for human 2-oxoglutarate (2OG)dependent oxygenases.	./cache/cord-355377-b0rcg3rt.txt	./txt/cord-355377-b0rcg3rt.txt