id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-355924-8sk9al0n	Allam, Loubna	Targeting the GRP78-Dependant SARS-CoV-2 Cell Entry by Peptides and Small Molecules	2020-10-21		.txt	text/plain	4753	288	52	Here, we report potential inhibitors comprising small molecules and peptides that could interfere with the interaction of SARS-CoV-2 and its target cells by blocking the recognition of the GRP78 cellular receptor by the viral Spike protein. For this purpose, a targeted analysis of the expression of candidate genes involved in SARS-CoV-2 infection confirmed the presence of the GRP78 protein in vitro in epithelial cells of the human respiratory tract and lung tissue. In this direction, our study focused on the repositioning of approved drugs as well as the investigation of other bioactive compounds that may prevent the penetration of SARS-CoV-2 into host cells by targeting the region of GRP78 that is required for the interaction with the Spike protein of the virus. Inhibition of the interaction between the spike protein SARS-CoV-2 and the receptor by blocking the GRP78 is a strategy interesting to identify drugs that decrease the rate of viral infection.	./cache/cord-355924-8sk9al0n.txt	./txt/cord-355924-8sk9al0n.txt