id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-356019-k7gs1ohp	Makhzoum, Abdullah	Recent advances on host plants and expression cassettes' structure and function in plant molecular pharming	2013-08-20		.txt	text/plain	8923	405	40	As molecular pharming platforms, plants are excellent biofactories for the production of drugs, antibodies, and vaccines in various host systems such as whole transgenic plants, cell suspension culture, hairy roots, and hydroponic culture [1] [2] [3] . Here, we review these aspects and report recent advances in the improvements of plant molecular pharming to increase protein yield and accumulation based on upstream and downstream processing studies and empirical essays. In addition to the importance of promoter architecture for gene expression in molecular pharming, other strategies based on using specific peptides at N-and C-termini have been employed to enhance the transcript level of recombinant proteins. For example, the production and accumulation of the recombinant human granulocyte colony-stimulating factor was significantly increased in transgenic rice suspension culture by an RNAi approach designed to suppress the cysteine proteinase gene expression or by the inhibition of proteinase [104, 105] .	./cache/cord-356019-k7gs1ohp.txt	./txt/cord-356019-k7gs1ohp.txt