id	sid	tid	token	lemma	pos
cord-000372-wzwpyvll	1	1	key	key	NN
cord-000372-wzwpyvll	1	2	:	:	:
cord-000372-wzwpyvll	2	1	cord-000372-wzwpyvll	cord-000372-wzwpyvll	NNP
cord-000372-wzwpyvll	2	2	authors	author	NNS
cord-000372-wzwpyvll	2	3	:	:	:
cord-000372-wzwpyvll	2	4	Castelló	Castelló	NNP
cord-000372-wzwpyvll	2	5	,	,	,
cord-000372-wzwpyvll	2	6	Alfredo	Alfredo	NNP
cord-000372-wzwpyvll	2	7	;	;	:
cord-000372-wzwpyvll	2	8	Álvarez	Álvarez	NNP
cord-000372-wzwpyvll	2	9	,	,	,
cord-000372-wzwpyvll	2	10	Enrique	Enrique	NNP
cord-000372-wzwpyvll	2	11	;	;	:
cord-000372-wzwpyvll	2	12	Carrasco	Carrasco	NNP
cord-000372-wzwpyvll	2	13	,	,	,
cord-000372-wzwpyvll	3	1	Luis	Luis	NNP
cord-000372-wzwpyvll	3	2	title	title	NN
cord-000372-wzwpyvll	3	3	:	:	:
cord-000372-wzwpyvll	4	1	The	the	DT
cord-000372-wzwpyvll	4	2	Multifaceted	multifaceted	JJ
cord-000372-wzwpyvll	4	3	Poliovirus	Poliovirus	NNP
cord-000372-wzwpyvll	4	4	2A	2a	NN
cord-000372-wzwpyvll	4	5	Protease	Protease	NNP
cord-000372-wzwpyvll	4	6	:	:	:
cord-000372-wzwpyvll	4	7	Regulation	regulation	NN
cord-000372-wzwpyvll	4	8	of	of	IN
cord-000372-wzwpyvll	4	9	Gene	Gene	NNP
cord-000372-wzwpyvll	4	10	Expression	Expression	NNP
cord-000372-wzwpyvll	4	11	by	by	IN
cord-000372-wzwpyvll	4	12	Picornavirus	Picornavirus	NNP
cord-000372-wzwpyvll	4	13	Proteases	Proteases	NNP
cord-000372-wzwpyvll	4	14	date	date	NN
cord-000372-wzwpyvll	4	15	:	:	:
cord-000372-wzwpyvll	4	16	2011	2011	CD
cord-000372-wzwpyvll	4	17	-	-	HYPH
cord-000372-wzwpyvll	4	18	04	04	CD
cord-000372-wzwpyvll	4	19	-	-	SYM
cord-000372-wzwpyvll	4	20	14	14	CD
cord-000372-wzwpyvll	4	21	journal	journal	NN
cord-000372-wzwpyvll	4	22	:	:	:
cord-000372-wzwpyvll	4	23	J	J	NNP
cord-000372-wzwpyvll	4	24	Biomed	Biomed	NNP
cord-000372-wzwpyvll	4	25	Biotechnol	Biotechnol	NNP
cord-000372-wzwpyvll	4	26	DOI	DOI	NNP
cord-000372-wzwpyvll	4	27	:	:	:
cord-000372-wzwpyvll	5	1	10.1155/2011/369648	10.1155/2011/369648	NNP
cord-000372-wzwpyvll	6	1	sha	sha	NNP
cord-000372-wzwpyvll	6	2	:	:	:
cord-000372-wzwpyvll	6	3	5bff40b0df656057c9db88470a3b84b40f0eeb28	5bff40b0df656057c9db88470a3b84b40f0eeb28	CD
cord-000372-wzwpyvll	6	4	doc_id	doc_id	CD
cord-000372-wzwpyvll	6	5	:	:	:
cord-000372-wzwpyvll	6	6	372	372	CD
cord-000372-wzwpyvll	6	7	cord_uid	cord_uid	NNS
cord-000372-wzwpyvll	6	8	:	:	:
cord-000372-wzwpyvll	6	9	wzwpyvll	wzwpyvll	NN
cord-000372-wzwpyvll	7	1	After	after	IN
cord-000372-wzwpyvll	7	2	entry	entry	NN
cord-000372-wzwpyvll	7	3	into	into	IN
cord-000372-wzwpyvll	7	4	animal	animal	NN
cord-000372-wzwpyvll	7	5	cells	cell	NNS
cord-000372-wzwpyvll	7	6	,	,	,
cord-000372-wzwpyvll	7	7	most	most	JJS
cord-000372-wzwpyvll	7	8	viruses	virus	NNS
cord-000372-wzwpyvll	7	9	hijack	hijack	VBP
cord-000372-wzwpyvll	7	10	essential	essential	JJ
cord-000372-wzwpyvll	7	11	components	component	NNS
cord-000372-wzwpyvll	7	12	involved	involve	VBN
cord-000372-wzwpyvll	7	13	in	in	IN
cord-000372-wzwpyvll	7	14	gene	gene	NN
cord-000372-wzwpyvll	7	15	expression	expression	NN
cord-000372-wzwpyvll	7	16	.	.	.
cord-000372-wzwpyvll	8	1	This	this	DT
cord-000372-wzwpyvll	8	2	is	be	VBZ
cord-000372-wzwpyvll	8	3	the	the	DT
cord-000372-wzwpyvll	8	4	case	case	NN
cord-000372-wzwpyvll	8	5	of	of	IN
cord-000372-wzwpyvll	8	6	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	8	7	,	,	,
cord-000372-wzwpyvll	8	8	which	which	WDT
cord-000372-wzwpyvll	8	9	abrogates	abrogate	VBZ
cord-000372-wzwpyvll	8	10	cellular	cellular	JJ
cord-000372-wzwpyvll	8	11	translation	translation	NN
cord-000372-wzwpyvll	8	12	soon	soon	RB
cord-000372-wzwpyvll	8	13	after	after	IN
cord-000372-wzwpyvll	8	14	virus	virus	NN
cord-000372-wzwpyvll	8	15	internalization	internalization	NN
cord-000372-wzwpyvll	8	16	.	.	.
cord-000372-wzwpyvll	9	1	Abrogation	abrogation	NN
cord-000372-wzwpyvll	9	2	is	be	VBZ
cord-000372-wzwpyvll	9	3	achieved	achieve	VBN
cord-000372-wzwpyvll	9	4	by	by	IN
cord-000372-wzwpyvll	9	5	cleavage	cleavage	NN
cord-000372-wzwpyvll	9	6	of	of	IN
cord-000372-wzwpyvll	9	7	both	both	DT
cord-000372-wzwpyvll	9	8	eIF4GI	eIF4GI	NNS
cord-000372-wzwpyvll	9	9	and	and	CC
cord-000372-wzwpyvll	9	10	eIF4GII	eif4gii	NN
cord-000372-wzwpyvll	9	11	by	by	IN
cord-000372-wzwpyvll	9	12	the	the	DT
cord-000372-wzwpyvll	9	13	viral	viral	JJ
cord-000372-wzwpyvll	9	14	protease	protease	NN
cord-000372-wzwpyvll	9	15	2A.	2a.	CD
cord-000372-wzwpyvll	10	1	Apart	apart	RB
cord-000372-wzwpyvll	10	2	from	from	IN
cord-000372-wzwpyvll	10	3	the	the	DT
cord-000372-wzwpyvll	10	4	interference	interference	NN
cord-000372-wzwpyvll	10	5	of	of	IN
cord-000372-wzwpyvll	10	6	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	10	7	with	with	IN
cord-000372-wzwpyvll	10	8	cellular	cellular	JJ
cord-000372-wzwpyvll	10	9	protein	protein	NN
cord-000372-wzwpyvll	10	10	synthesis	synthesis	NN
cord-000372-wzwpyvll	10	11	,	,	,
cord-000372-wzwpyvll	10	12	other	other	JJ
cord-000372-wzwpyvll	10	13	gene	gene	NN
cord-000372-wzwpyvll	10	14	expression	expression	NN
cord-000372-wzwpyvll	10	15	steps	step	NNS
cord-000372-wzwpyvll	10	16	such	such	JJ
cord-000372-wzwpyvll	10	17	as	as	IN
cord-000372-wzwpyvll	10	18	RNA	RNA	NNP
cord-000372-wzwpyvll	10	19	and	and	CC
cord-000372-wzwpyvll	10	20	protein	protein	NN
cord-000372-wzwpyvll	10	21	trafficking	trafficking	NN
cord-000372-wzwpyvll	10	22	between	between	IN
cord-000372-wzwpyvll	10	23	nucleus	nucleus	NN
cord-000372-wzwpyvll	10	24	and	and	CC
cord-000372-wzwpyvll	10	25	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	10	26	are	be	VBP
cord-000372-wzwpyvll	10	27	also	also	RB
cord-000372-wzwpyvll	10	28	altered	alter	VBN
cord-000372-wzwpyvll	10	29	.	.	.
cord-000372-wzwpyvll	11	1	Poliovirus	Poliovirus	NNP
cord-000372-wzwpyvll	11	2	2A(pro	2a(pro	CD
cord-000372-wzwpyvll	11	3	)	)	-RRB-
cord-000372-wzwpyvll	11	4	is	be	VBZ
cord-000372-wzwpyvll	11	5	capable	capable	JJ
cord-000372-wzwpyvll	11	6	of	of	IN
cord-000372-wzwpyvll	11	7	hydrolyzing	hydrolyze	VBG
cord-000372-wzwpyvll	11	8	components	component	NNS
cord-000372-wzwpyvll	11	9	of	of	IN
cord-000372-wzwpyvll	11	10	the	the	DT
cord-000372-wzwpyvll	11	11	nuclear	nuclear	JJ
cord-000372-wzwpyvll	11	12	pore	pore	NN
cord-000372-wzwpyvll	11	13	,	,	,
cord-000372-wzwpyvll	11	14	thus	thus	RB
cord-000372-wzwpyvll	11	15	preventing	prevent	VBG
cord-000372-wzwpyvll	11	16	an	an	DT
cord-000372-wzwpyvll	11	17	efficient	efficient	JJ
cord-000372-wzwpyvll	11	18	antiviral	antiviral	JJ
cord-000372-wzwpyvll	11	19	response	response	NN
cord-000372-wzwpyvll	11	20	by	by	IN
cord-000372-wzwpyvll	11	21	the	the	DT
cord-000372-wzwpyvll	11	22	host	host	NN
cord-000372-wzwpyvll	11	23	cell	cell	NN
cord-000372-wzwpyvll	11	24	.	.	.
cord-000372-wzwpyvll	12	1	Here	here	RB
cord-000372-wzwpyvll	12	2	,	,	,
cord-000372-wzwpyvll	12	3	we	-PRON-	PRP
cord-000372-wzwpyvll	12	4	compare	compare	VBP
cord-000372-wzwpyvll	12	5	in	in	IN
cord-000372-wzwpyvll	12	6	detail	detail	NN
cord-000372-wzwpyvll	12	7	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	12	8	2A(pro	2a(pro	CD
cord-000372-wzwpyvll	12	9	)	)	-RRB-
cord-000372-wzwpyvll	12	10	with	with	IN
cord-000372-wzwpyvll	12	11	other	other	JJ
cord-000372-wzwpyvll	12	12	viral	viral	JJ
cord-000372-wzwpyvll	12	13	proteins	protein	NNS
cord-000372-wzwpyvll	12	14	(	(	-LRB-
cord-000372-wzwpyvll	12	15	from	from	IN
cord-000372-wzwpyvll	12	16	picornaviruses	picornavirus	NNS
cord-000372-wzwpyvll	12	17	and	and	CC
cord-000372-wzwpyvll	12	18	unrelated	unrelated	JJ
cord-000372-wzwpyvll	12	19	families	family	NNS
cord-000372-wzwpyvll	12	20	)	)	-RRB-
cord-000372-wzwpyvll	12	21	as	as	IN
cord-000372-wzwpyvll	12	22	regard	regard	NN
cord-000372-wzwpyvll	12	23	to	to	IN
cord-000372-wzwpyvll	12	24	their	-PRON-	PRP$
cord-000372-wzwpyvll	12	25	activity	activity	NN
cord-000372-wzwpyvll	12	26	on	on	IN
cord-000372-wzwpyvll	12	27	key	key	JJ
cord-000372-wzwpyvll	12	28	host	host	NN
cord-000372-wzwpyvll	12	29	factors	factor	NNS
cord-000372-wzwpyvll	12	30	that	that	WDT
cord-000372-wzwpyvll	12	31	control	control	VBP
cord-000372-wzwpyvll	12	32	gene	gene	NN
cord-000372-wzwpyvll	12	33	expression	expression	NN
cord-000372-wzwpyvll	12	34	.	.	.
cord-000372-wzwpyvll	13	1	It	-PRON-	PRP
cord-000372-wzwpyvll	13	2	is	be	VBZ
cord-000372-wzwpyvll	13	3	possible	possible	JJ
cord-000372-wzwpyvll	13	4	that	that	IN
cord-000372-wzwpyvll	13	5	future	future	JJ
cord-000372-wzwpyvll	13	6	analyses	analysis	NNS
cord-000372-wzwpyvll	13	7	to	to	TO
cord-000372-wzwpyvll	13	8	determine	determine	VB
cord-000372-wzwpyvll	13	9	the	the	DT
cord-000372-wzwpyvll	13	10	cellular	cellular	JJ
cord-000372-wzwpyvll	13	11	proteins	protein	NNS
cord-000372-wzwpyvll	13	12	targeted	target	VBN
cord-000372-wzwpyvll	13	13	by	by	IN
cord-000372-wzwpyvll	13	14	2A(pro	2a(pro	CD
cord-000372-wzwpyvll	13	15	)	)	-RRB-
cord-000372-wzwpyvll	13	16	will	will	MD
cord-000372-wzwpyvll	13	17	uncover	uncover	VB
cord-000372-wzwpyvll	13	18	other	other	JJ
cord-000372-wzwpyvll	13	19	cellular	cellular	JJ
cord-000372-wzwpyvll	13	20	functions	function	NNS
cord-000372-wzwpyvll	13	21	ablated	ablate	VBN
cord-000372-wzwpyvll	13	22	by	by	IN
cord-000372-wzwpyvll	13	23	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	13	24	infection	infection	NN
cord-000372-wzwpyvll	13	25	.	.	.
cord-000372-wzwpyvll	14	1	Further	further	JJ
cord-000372-wzwpyvll	14	2	understanding	understanding	NN
cord-000372-wzwpyvll	14	3	of	of	IN
cord-000372-wzwpyvll	14	4	the	the	DT
cord-000372-wzwpyvll	14	5	cellular	cellular	JJ
cord-000372-wzwpyvll	14	6	proteins	protein	NNS
cord-000372-wzwpyvll	14	7	hydrolyzed	hydrolyze	VBN
cord-000372-wzwpyvll	14	8	by	by	IN
cord-000372-wzwpyvll	14	9	2A(pro	2a(pro	CD
cord-000372-wzwpyvll	14	10	)	)	-RRB-
cord-000372-wzwpyvll	14	11	will	will	MD
cord-000372-wzwpyvll	14	12	add	add	VB
cord-000372-wzwpyvll	14	13	further	further	JJ
cord-000372-wzwpyvll	14	14	insight	insight	NN
cord-000372-wzwpyvll	14	15	into	into	IN
cord-000372-wzwpyvll	14	16	the	the	DT
cord-000372-wzwpyvll	14	17	molecular	molecular	JJ
cord-000372-wzwpyvll	14	18	mechanism	mechanism	NN
cord-000372-wzwpyvll	14	19	by	by	IN
cord-000372-wzwpyvll	14	20	which	which	WDT
cord-000372-wzwpyvll	14	21	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	14	22	and	and	CC
cord-000372-wzwpyvll	14	23	other	other	JJ
cord-000372-wzwpyvll	14	24	viruses	virus	NNS
cord-000372-wzwpyvll	14	25	interact	interact	VBP
cord-000372-wzwpyvll	14	26	with	with	IN
cord-000372-wzwpyvll	14	27	the	the	DT
cord-000372-wzwpyvll	14	28	host	host	NN
cord-000372-wzwpyvll	14	29	cell	cell	NN
cord-000372-wzwpyvll	14	30	.	.	.
cord-000372-wzwpyvll	15	1	A	a	DT
cord-000372-wzwpyvll	15	2	great	great	JJ
cord-000372-wzwpyvll	15	3	variety	variety	NN
cord-000372-wzwpyvll	15	4	of	of	IN
cord-000372-wzwpyvll	15	5	animal	animal	NN
cord-000372-wzwpyvll	15	6	viruses	virus	NNS
cord-000372-wzwpyvll	15	7	encode	encode	VBP
cord-000372-wzwpyvll	15	8	for	for	IN
cord-000372-wzwpyvll	15	9	proteases	protease	NNS
cord-000372-wzwpyvll	15	10	that	that	WDT
cord-000372-wzwpyvll	15	11	accomplish	accomplish	VBP
cord-000372-wzwpyvll	15	12	crucial	crucial	JJ
cord-000372-wzwpyvll	15	13	functions	function	NNS
cord-000372-wzwpyvll	15	14	during	during	IN
cord-000372-wzwpyvll	15	15	the	the	DT
cord-000372-wzwpyvll	15	16	biological	biological	JJ
cord-000372-wzwpyvll	15	17	cycle	cycle	NN
cord-000372-wzwpyvll	15	18	of	of	IN
cord-000372-wzwpyvll	15	19	the	the	DT
cord-000372-wzwpyvll	15	20	virus	virus	NN
cord-000372-wzwpyvll	15	21	[	[	-LRB-
cord-000372-wzwpyvll	15	22	1	1	CD
cord-000372-wzwpyvll	15	23	]	]	-RRB-
cord-000372-wzwpyvll	15	24	.	.	.
cord-000372-wzwpyvll	16	1	Usually	usually	RB
cord-000372-wzwpyvll	16	2	,	,	,
cord-000372-wzwpyvll	16	3	the	the	DT
cord-000372-wzwpyvll	16	4	main	main	JJ
cord-000372-wzwpyvll	16	5	function	function	NN
cord-000372-wzwpyvll	16	6	of	of	IN
cord-000372-wzwpyvll	16	7	these	these	DT
cord-000372-wzwpyvll	16	8	proteases	protease	NNS
cord-000372-wzwpyvll	16	9	is	be	VBZ
cord-000372-wzwpyvll	16	10	to	to	IN
cord-000372-wzwpyvll	16	11	proteolyze	proteolyze	VBN
cord-000372-wzwpyvll	16	12	viral	viral	JJ
cord-000372-wzwpyvll	16	13	polypeptide	polypeptide	NN
cord-000372-wzwpyvll	16	14	precursors	precursor	NNS
cord-000372-wzwpyvll	16	15	to	to	TO
cord-000372-wzwpyvll	16	16	render	render	VB
cord-000372-wzwpyvll	16	17	mature	mature	JJ
cord-000372-wzwpyvll	16	18	viral	viral	JJ
cord-000372-wzwpyvll	16	19	proteins	protein	NNS
cord-000372-wzwpyvll	16	20	that	that	WDT
cord-000372-wzwpyvll	16	21	form	form	VBP
cord-000372-wzwpyvll	16	22	part	part	NN
cord-000372-wzwpyvll	16	23	of	of	IN
cord-000372-wzwpyvll	16	24	viral	viral	JJ
cord-000372-wzwpyvll	16	25	capsids	capsid	NNS
cord-000372-wzwpyvll	16	26	or	or	CC
cord-000372-wzwpyvll	16	27	participate	participate	VB
cord-000372-wzwpyvll	16	28	in	in	IN
cord-000372-wzwpyvll	16	29	virus	virus	NN
cord-000372-wzwpyvll	16	30	vegetative	vegetative	JJ
cord-000372-wzwpyvll	16	31	processes	process	NNS
cord-000372-wzwpyvll	16	32	[	[	-LRB-
cord-000372-wzwpyvll	16	33	2	2	CD
cord-000372-wzwpyvll	16	34	]	]	-RRB-
cord-000372-wzwpyvll	16	35	.	.	.
cord-000372-wzwpyvll	17	1	Although	although	IN
cord-000372-wzwpyvll	17	2	both	both	DT
cord-000372-wzwpyvll	17	3	DNA	DNA	NNP
cord-000372-wzwpyvll	17	4	and	and	CC
cord-000372-wzwpyvll	17	5	RNA	RNA	NNP
cord-000372-wzwpyvll	17	6	viruses	virus	NNS
cord-000372-wzwpyvll	17	7	can	can	MD
cord-000372-wzwpyvll	17	8	encode	encode	VB
cord-000372-wzwpyvll	17	9	proteases	protease	NNS
cord-000372-wzwpyvll	17	10	,	,	,
cord-000372-wzwpyvll	17	11	the	the	DT
cord-000372-wzwpyvll	17	12	proteolytic	proteolytic	JJ
cord-000372-wzwpyvll	17	13	tailoring	tailoring	NN
cord-000372-wzwpyvll	17	14	of	of	IN
cord-000372-wzwpyvll	17	15	polypeptide	polypeptide	NN
cord-000372-wzwpyvll	17	16	precursors	precursor	NNS
cord-000372-wzwpyvll	17	17	is	be	VBZ
cord-000372-wzwpyvll	17	18	most	most	RBS
cord-000372-wzwpyvll	17	19	common	common	JJ
cord-000372-wzwpyvll	17	20	among	among	IN
cord-000372-wzwpyvll	17	21	viruses	virus	NNS
cord-000372-wzwpyvll	17	22	with	with	IN
cord-000372-wzwpyvll	17	23	positive	positive	JJ
cord-000372-wzwpyvll	17	24	single	single	JJ
cord-000372-wzwpyvll	17	25	-	-	HYPH
cord-000372-wzwpyvll	17	26	stranded	strand	VBN
cord-000372-wzwpyvll	17	27	RNA	RNA	NNP
cord-000372-wzwpyvll	17	28	genomes	genome	NNS
cord-000372-wzwpyvll	17	29	,	,	,
cord-000372-wzwpyvll	17	30	such	such	JJ
cord-000372-wzwpyvll	17	31	as	as	IN
cord-000372-wzwpyvll	17	32	picornaviruses	picornaviruses	NNP
cord-000372-wzwpyvll	17	33	,	,	,
cord-000372-wzwpyvll	17	34	flaviviruses	flaviviruses	NNP
cord-000372-wzwpyvll	17	35	,	,	,
cord-000372-wzwpyvll	17	36	caliciviruses	caliciviruse	NNS
cord-000372-wzwpyvll	17	37	,	,	,
cord-000372-wzwpyvll	17	38	and	and	CC
cord-000372-wzwpyvll	17	39	retroviruses	retrovirus	NNS
cord-000372-wzwpyvll	17	40	[	[	-LRB-
cord-000372-wzwpyvll	17	41	3	3	CD
cord-000372-wzwpyvll	17	42	]	]	-RRB-
cord-000372-wzwpyvll	17	43	[	[	-LRB-
cord-000372-wzwpyvll	17	44	4	4	CD
cord-000372-wzwpyvll	17	45	]	]	-RRB-
cord-000372-wzwpyvll	17	46	[	[	-LRB-
cord-000372-wzwpyvll	17	47	5	5	CD
cord-000372-wzwpyvll	17	48	]	]	-RRB-
cord-000372-wzwpyvll	17	49	[	[	-LRB-
cord-000372-wzwpyvll	17	50	6	6	CD
cord-000372-wzwpyvll	17	51	]	]	-RRB-
cord-000372-wzwpyvll	17	52	[	[	-LRB-
cord-000372-wzwpyvll	17	53	7	7	CD
cord-000372-wzwpyvll	17	54	]	]	-RRB-
cord-000372-wzwpyvll	17	55	.	.	.
cord-000372-wzwpyvll	18	1	This	this	DT
cord-000372-wzwpyvll	18	2	mechanism	mechanism	NN
cord-000372-wzwpyvll	18	3	of	of	IN
cord-000372-wzwpyvll	18	4	gene	gene	NN
cord-000372-wzwpyvll	18	5	expression	expression	NN
cord-000372-wzwpyvll	18	6	by	by	IN
cord-000372-wzwpyvll	18	7	proteolytic	proteolytic	JJ
cord-000372-wzwpyvll	18	8	processing	processing	NN
cord-000372-wzwpyvll	18	9	serves	serve	VBZ
cord-000372-wzwpyvll	18	10	to	to	TO
cord-000372-wzwpyvll	18	11	compress	compress	VB
cord-000372-wzwpyvll	18	12	the	the	DT
cord-000372-wzwpyvll	18	13	genetic	genetic	JJ
cord-000372-wzwpyvll	18	14	information	information	NN
cord-000372-wzwpyvll	18	15	of	of	IN
cord-000372-wzwpyvll	18	16	viruses	virus	NNS
cord-000372-wzwpyvll	18	17	in	in	IN
cord-000372-wzwpyvll	18	18	the	the	DT
cord-000372-wzwpyvll	18	19	limited	limited	JJ
cord-000372-wzwpyvll	18	20	space	space	NN
cord-000372-wzwpyvll	18	21	provided	provide	VBN
cord-000372-wzwpyvll	18	22	by	by	IN
cord-000372-wzwpyvll	18	23	the	the	DT
cord-000372-wzwpyvll	18	24	genome	genome	NN
cord-000372-wzwpyvll	18	25	.	.	.
cord-000372-wzwpyvll	19	1	In	in	IN
cord-000372-wzwpyvll	19	2	this	this	DT
cord-000372-wzwpyvll	19	3	manner	manner	NN
cord-000372-wzwpyvll	19	4	,	,	,
cord-000372-wzwpyvll	19	5	viruses	virus	NNS
cord-000372-wzwpyvll	19	6	reduce	reduce	VBP
cord-000372-wzwpyvll	19	7	the	the	DT
cord-000372-wzwpyvll	19	8	genetic	genetic	JJ
cord-000372-wzwpyvll	19	9	space	space	NN
cord-000372-wzwpyvll	19	10	occupied	occupy	VBN
cord-000372-wzwpyvll	19	11	by	by	IN
cord-000372-wzwpyvll	19	12	5	5	CD
cord-000372-wzwpyvll	19	13	and	and	CC
cord-000372-wzwpyvll	19	14	3	3	CD
cord-000372-wzwpyvll	19	15	untranslated	untranslated	JJ
cord-000372-wzwpyvll	19	16	regions	region	NNS
cord-000372-wzwpyvll	19	17	(	(	-LRB-
cord-000372-wzwpyvll	19	18	UTRs	UTRs	NNP
cord-000372-wzwpyvll	19	19	)	)	-RRB-
cord-000372-wzwpyvll	19	20	,	,	,
cord-000372-wzwpyvll	19	21	the	the	DT
cord-000372-wzwpyvll	19	22	signals	signal	NNS
cord-000372-wzwpyvll	19	23	devoted	devote	VBN
cord-000372-wzwpyvll	19	24	for	for	IN
cord-000372-wzwpyvll	19	25	mRNA	mrna	NN
cord-000372-wzwpyvll	19	26	transcription	transcription	NN
cord-000372-wzwpyvll	19	27	and	and	CC
cord-000372-wzwpyvll	19	28	to	to	TO
cord-000372-wzwpyvll	19	29	initiate	initiate	VB
cord-000372-wzwpyvll	19	30	translation	translation	NN
cord-000372-wzwpyvll	19	31	are	be	VBP
cord-000372-wzwpyvll	19	32	minimal	minimal	JJ
cord-000372-wzwpyvll	19	33	,	,	,
cord-000372-wzwpyvll	19	34	such	such	JJ
cord-000372-wzwpyvll	19	35	that	that	IN
cord-000372-wzwpyvll	19	36	,	,	,
cord-000372-wzwpyvll	19	37	for	for	IN
cord-000372-wzwpyvll	19	38	instance	instance	NN
cord-000372-wzwpyvll	19	39	,	,	,
cord-000372-wzwpyvll	19	40	in	in	IN
cord-000372-wzwpyvll	19	41	the	the	DT
cord-000372-wzwpyvll	19	42	case	case	NN
cord-000372-wzwpyvll	19	43	of	of	IN
cord-000372-wzwpyvll	19	44	picornaviruses	picornavirus	NNS
cord-000372-wzwpyvll	19	45	or	or	CC
cord-000372-wzwpyvll	19	46	flaviviruses	flavivirus	NNS
cord-000372-wzwpyvll	19	47	,	,	,
cord-000372-wzwpyvll	19	48	only	only	RB
cord-000372-wzwpyvll	19	49	one	one	CD
cord-000372-wzwpyvll	19	50	5	5	CD
cord-000372-wzwpyvll	19	51	and	and	CC
cord-000372-wzwpyvll	19	52	3	3	CD
cord-000372-wzwpyvll	19	53	UTR	UTR	NNP
cord-000372-wzwpyvll	19	54	is	be	VBZ
cord-000372-wzwpyvll	19	55	necessary	necessary	JJ
cord-000372-wzwpyvll	19	56	for	for	IN
cord-000372-wzwpyvll	19	57	viral	viral	JJ
cord-000372-wzwpyvll	19	58	replication	replication	NN
cord-000372-wzwpyvll	19	59	,	,	,
cord-000372-wzwpyvll	19	60	transcription	transcription	NN
cord-000372-wzwpyvll	19	61	,	,	,
cord-000372-wzwpyvll	19	62	translation	translation	NN
cord-000372-wzwpyvll	19	63	,	,	,
cord-000372-wzwpyvll	19	64	and	and	CC
cord-000372-wzwpyvll	19	65	morphogenesis	morphogenesis	NN
cord-000372-wzwpyvll	19	66	,	,	,
cord-000372-wzwpyvll	19	67	despite	despite	IN
cord-000372-wzwpyvll	19	68	the	the	DT
cord-000372-wzwpyvll	19	69	fact	fact	NN
cord-000372-wzwpyvll	19	70	that	that	IN
cord-000372-wzwpyvll	19	71	several	several	JJ
cord-000372-wzwpyvll	19	72	viral	viral	JJ
cord-000372-wzwpyvll	19	73	proteins	protein	NNS
cord-000372-wzwpyvll	19	74	are	be	VBP
cord-000372-wzwpyvll	19	75	synthesized	synthesize	VBN
cord-000372-wzwpyvll	19	76	by	by	IN
cord-000372-wzwpyvll	19	77	the	the	DT
cord-000372-wzwpyvll	19	78	infected	infected	JJ
cord-000372-wzwpyvll	19	79	cells	cell	NNS
cord-000372-wzwpyvll	19	80	.	.	.
cord-000372-wzwpyvll	20	1	In	in	IN
cord-000372-wzwpyvll	20	2	addition	addition	NN
cord-000372-wzwpyvll	20	3	,	,	,
cord-000372-wzwpyvll	20	4	a	a	DT
cord-000372-wzwpyvll	20	5	number	number	NN
cord-000372-wzwpyvll	20	6	of	of	IN
cord-000372-wzwpyvll	20	7	polypeptide	polypeptide	JJ
cord-000372-wzwpyvll	20	8	precursors	precursor	NNS
cord-000372-wzwpyvll	20	9	may	may	MD
cord-000372-wzwpyvll	20	10	exhibit	exhibit	VB
cord-000372-wzwpyvll	20	11	functions	function	NNS
cord-000372-wzwpyvll	20	12	that	that	WDT
cord-000372-wzwpyvll	20	13	differ	differ	VBP
cord-000372-wzwpyvll	20	14	from	from	IN
cord-000372-wzwpyvll	20	15	those	those	DT
cord-000372-wzwpyvll	20	16	present	present	JJ
cord-000372-wzwpyvll	20	17	in	in	IN
cord-000372-wzwpyvll	20	18	their	-PRON-	PRP$
cord-000372-wzwpyvll	20	19	mature	mature	JJ
cord-000372-wzwpyvll	20	20	products	product	NNS
cord-000372-wzwpyvll	20	21	.	.	.
cord-000372-wzwpyvll	21	1	In	in	IN
cord-000372-wzwpyvll	21	2	the	the	DT
cord-000372-wzwpyvll	21	3	case	case	NN
cord-000372-wzwpyvll	21	4	of	of	IN
cord-000372-wzwpyvll	21	5	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	21	6	(	(	-LRB-
cord-000372-wzwpyvll	21	7	PV	PV	NNP
cord-000372-wzwpyvll	21	8	)	)	-RRB-
cord-000372-wzwpyvll	21	9	,	,	,
cord-000372-wzwpyvll	21	10	eleven	eleven	CD
cord-000372-wzwpyvll	21	11	mature	mature	JJ
cord-000372-wzwpyvll	21	12	proteins	protein	NNS
cord-000372-wzwpyvll	21	13	are	be	VBP
cord-000372-wzwpyvll	21	14	produced	produce	VBN
cord-000372-wzwpyvll	21	15	from	from	IN
cord-000372-wzwpyvll	21	16	a	a	DT
cord-000372-wzwpyvll	21	17	single	single	JJ
cord-000372-wzwpyvll	21	18	translation	translation	NN
cord-000372-wzwpyvll	21	19	initiation	initiation	NN
cord-000372-wzwpyvll	21	20	event	event	NN
cord-000372-wzwpyvll	21	21	,	,	,
cord-000372-wzwpyvll	21	22	and	and	CC
cord-000372-wzwpyvll	21	23	at	at	RB
cord-000372-wzwpyvll	21	24	least	least	RBS
cord-000372-wzwpyvll	21	25	two	two	CD
cord-000372-wzwpyvll	21	26	precursors	precursor	NNS
cord-000372-wzwpyvll	21	27	,	,	,
cord-000372-wzwpyvll	21	28	2BC	2BC	NNP
cord-000372-wzwpyvll	21	29	and	and	CC
cord-000372-wzwpyvll	21	30	3CD	3CD	NNP
cord-000372-wzwpyvll	21	31	,	,	,
cord-000372-wzwpyvll	21	32	accomplish	accomplish	NN
cord-000372-wzwpyvll	21	33	functions	function	NNS
cord-000372-wzwpyvll	21	34	which	which	WDT
cord-000372-wzwpyvll	21	35	are	be	VBP
cord-000372-wzwpyvll	21	36	not	not	RB
cord-000372-wzwpyvll	21	37	present	present	JJ
cord-000372-wzwpyvll	21	38	in	in	IN
cord-000372-wzwpyvll	21	39	their	-PRON-	PRP$
cord-000372-wzwpyvll	21	40	mature	mature	JJ
cord-000372-wzwpyvll	21	41	proteins	protein	NNS
cord-000372-wzwpyvll	21	42	.	.	.
cord-000372-wzwpyvll	22	1	Taking	take	VBG
cord-000372-wzwpyvll	22	2	together	together	RB
cord-000372-wzwpyvll	22	3	all	all	PDT
cord-000372-wzwpyvll	22	4	these	these	DT
cord-000372-wzwpyvll	22	5	considerations	consideration	NNS
cord-000372-wzwpyvll	22	6	,	,	,
cord-000372-wzwpyvll	22	7	the	the	DT
cord-000372-wzwpyvll	22	8	"	"	``
cord-000372-wzwpyvll	22	9	proteolytic	proteolytic	JJ
cord-000372-wzwpyvll	22	10	strategy	strategy	NN
cord-000372-wzwpyvll	22	11	"	"	''
cord-000372-wzwpyvll	22	12	provides	provide	VBZ
cord-000372-wzwpyvll	22	13	the	the	DT
cord-000372-wzwpyvll	22	14	small	small	JJ
cord-000372-wzwpyvll	22	15	RNA	RNA	NNP
cord-000372-wzwpyvll	22	16	viruses	virus	NNS
cord-000372-wzwpyvll	22	17	with	with	IN
cord-000372-wzwpyvll	22	18	an	an	DT
cord-000372-wzwpyvll	22	19	advantageous	advantageous	JJ
cord-000372-wzwpyvll	22	20	and	and	CC
cord-000372-wzwpyvll	22	21	efficient	efficient	JJ
cord-000372-wzwpyvll	22	22	mechanism	mechanism	NN
cord-000372-wzwpyvll	22	23	for	for	IN
cord-000372-wzwpyvll	22	24	distribution	distribution	NN
cord-000372-wzwpyvll	22	25	of	of	IN
cord-000372-wzwpyvll	22	26	the	the	DT
cord-000372-wzwpyvll	22	27	genome	genome	NN
cord-000372-wzwpyvll	22	28	to	to	TO
cord-000372-wzwpyvll	22	29	accomplish	accomplish	VB
cord-000372-wzwpyvll	22	30	all	all	PDT
cord-000372-wzwpyvll	22	31	the	the	DT
cord-000372-wzwpyvll	22	32	viral	viral	JJ
cord-000372-wzwpyvll	22	33	biological	biological	JJ
cord-000372-wzwpyvll	22	34	functions	function	NNS
cord-000372-wzwpyvll	22	35	with	with	IN
cord-000372-wzwpyvll	22	36	the	the	DT
cord-000372-wzwpyvll	22	37	smaller	small	JJR
cord-000372-wzwpyvll	22	38	genetic	genetic	JJ
cord-000372-wzwpyvll	22	39	space	space	NN
cord-000372-wzwpyvll	22	40	.	.	.
cord-000372-wzwpyvll	23	1	Apart	apart	RB
cord-000372-wzwpyvll	23	2	from	from	IN
cord-000372-wzwpyvll	23	3	generation	generation	NN
cord-000372-wzwpyvll	23	4	of	of	IN
cord-000372-wzwpyvll	23	5	active	active	JJ
cord-000372-wzwpyvll	23	6	viral	viral	JJ
cord-000372-wzwpyvll	23	7	proteins	protein	NNS
cord-000372-wzwpyvll	23	8	that	that	WDT
cord-000372-wzwpyvll	23	9	participate	participate	VBP
cord-000372-wzwpyvll	23	10	in	in	IN
cord-000372-wzwpyvll	23	11	capsid	capsid	JJ
cord-000372-wzwpyvll	23	12	morphogenesis	morphogenesis	NN
cord-000372-wzwpyvll	23	13	and	and	CC
cord-000372-wzwpyvll	23	14	genome	genome	NN
cord-000372-wzwpyvll	23	15	replication	replication	NN
cord-000372-wzwpyvll	23	16	,	,	,
cord-000372-wzwpyvll	23	17	viral	viral	JJ
cord-000372-wzwpyvll	23	18	proteases	protease	NNS
cord-000372-wzwpyvll	23	19	may	may	MD
cord-000372-wzwpyvll	23	20	also	also	RB
cord-000372-wzwpyvll	23	21	target	target	VB
cord-000372-wzwpyvll	23	22	a	a	DT
cord-000372-wzwpyvll	23	23	number	number	NN
cord-000372-wzwpyvll	23	24	of	of	IN
cord-000372-wzwpyvll	23	25	cellular	cellular	JJ
cord-000372-wzwpyvll	23	26	proteins	protein	NNS
cord-000372-wzwpyvll	23	27	.	.	.
cord-000372-wzwpyvll	24	1	Proteolysis	Proteolysis	NNP
cord-000372-wzwpyvll	24	2	of	of	IN
cord-000372-wzwpyvll	24	3	these	these	DT
cord-000372-wzwpyvll	24	4	cellular	cellular	JJ
cord-000372-wzwpyvll	24	5	substrates	substrate	NNS
cord-000372-wzwpyvll	24	6	can	can	MD
cord-000372-wzwpyvll	24	7	very	very	RB
cord-000372-wzwpyvll	24	8	much	much	RB
cord-000372-wzwpyvll	24	9	affect	affect	VB
cord-000372-wzwpyvll	24	10	a	a	DT
cord-000372-wzwpyvll	24	11	variety	variety	NN
cord-000372-wzwpyvll	24	12	of	of	IN
cord-000372-wzwpyvll	24	13	cellular	cellular	JJ
cord-000372-wzwpyvll	24	14	processes	process	NNS
cord-000372-wzwpyvll	24	15	and	and	CC
cord-000372-wzwpyvll	24	16	play	play	VB
cord-000372-wzwpyvll	24	17	an	an	DT
cord-000372-wzwpyvll	24	18	important	important	JJ
cord-000372-wzwpyvll	24	19	role	role	NN
cord-000372-wzwpyvll	24	20	in	in	IN
cord-000372-wzwpyvll	24	21	virus	virus	NN
cord-000372-wzwpyvll	24	22	-	-	HYPH
cord-000372-wzwpyvll	24	23	induced	induce	VBN
cord-000372-wzwpyvll	24	24	cytopathogenesis	cytopathogenesis	NN
cord-000372-wzwpyvll	24	25	[	[	-LRB-
cord-000372-wzwpyvll	24	26	8	8	CD
cord-000372-wzwpyvll	24	27	,	,	,
cord-000372-wzwpyvll	24	28	9	9	CD
cord-000372-wzwpyvll	24	29	]	]	-RRB-
cord-000372-wzwpyvll	24	30	.	.	.
cord-000372-wzwpyvll	25	1	In	in	IN
cord-000372-wzwpyvll	25	2	this	this	DT
cord-000372-wzwpyvll	25	3	regard	regard	NN
cord-000372-wzwpyvll	25	4	,	,	,
cord-000372-wzwpyvll	25	5	productive	productive	JJ
cord-000372-wzwpyvll	25	6	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	25	7	infection	infection	NN
cord-000372-wzwpyvll	25	8	induces	induce	VBZ
cord-000372-wzwpyvll	25	9	rapid	rapid	JJ
cord-000372-wzwpyvll	25	10	morphological	morphological	JJ
cord-000372-wzwpyvll	25	11	alterations	alteration	NNS
cord-000372-wzwpyvll	25	12	in	in	IN
cord-000372-wzwpyvll	25	13	host	host	NN
cord-000372-wzwpyvll	25	14	-	-	HYPH
cord-000372-wzwpyvll	25	15	cell	cell	NN
cord-000372-wzwpyvll	25	16	.	.	.
cord-000372-wzwpyvll	26	1	Among	among	IN
cord-000372-wzwpyvll	26	2	them	-PRON-	PRP
cord-000372-wzwpyvll	26	3	,	,	,
cord-000372-wzwpyvll	26	4	the	the	DT
cord-000372-wzwpyvll	26	5	most	most	RBS
cord-000372-wzwpyvll	26	6	prevalent	prevalent	JJ
cord-000372-wzwpyvll	26	7	is	be	VBZ
cord-000372-wzwpyvll	26	8	the	the	DT
cord-000372-wzwpyvll	26	9	accumulation	accumulation	NN
cord-000372-wzwpyvll	26	10	of	of	IN
cord-000372-wzwpyvll	26	11	numerous	numerous	JJ
cord-000372-wzwpyvll	26	12	membranous	membranous	JJ
cord-000372-wzwpyvll	26	13	vesicles	vesicle	NNS
cord-000372-wzwpyvll	26	14	in	in	IN
cord-000372-wzwpyvll	26	15	the	the	DT
cord-000372-wzwpyvll	26	16	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	26	17	,	,	,
cord-000372-wzwpyvll	26	18	derived	derive	VBN
cord-000372-wzwpyvll	26	19	from	from	IN
cord-000372-wzwpyvll	26	20	endoplasmic	endoplasmic	NN
cord-000372-wzwpyvll	26	21	reticulum	reticulum	NN
cord-000372-wzwpyvll	26	22	where	where	WRB
cord-000372-wzwpyvll	26	23	the	the	DT
cord-000372-wzwpyvll	26	24	viral	viral	JJ
cord-000372-wzwpyvll	26	25	proteins	protein	NNS
cord-000372-wzwpyvll	26	26	2C	2C	NNP
cord-000372-wzwpyvll	26	27	and	and	CC
cord-000372-wzwpyvll	26	28	2BC	2BC	NNP
cord-000372-wzwpyvll	26	29	play	play	VBP
cord-000372-wzwpyvll	26	30	a	a	DT
cord-000372-wzwpyvll	26	31	central	central	JJ
cord-000372-wzwpyvll	26	32	role	role	NN
cord-000372-wzwpyvll	26	33	[	[	-LRB-
cord-000372-wzwpyvll	26	34	10	10	CD
cord-000372-wzwpyvll	26	35	]	]	-RRB-
cord-000372-wzwpyvll	26	36	.	.	.
cord-000372-wzwpyvll	27	1	In	in	IN
cord-000372-wzwpyvll	27	2	addition	addition	NN
cord-000372-wzwpyvll	27	3	,	,	,
cord-000372-wzwpyvll	27	4	cellular	cellular	JJ
cord-000372-wzwpyvll	27	5	shape	shape	NN
cord-000372-wzwpyvll	27	6	is	be	VBZ
cord-000372-wzwpyvll	27	7	modified	modify	VBN
cord-000372-wzwpyvll	27	8	upon	upon	IN
cord-000372-wzwpyvll	27	9	viral	viral	JJ
cord-000372-wzwpyvll	27	10	replication	replication	NN
cord-000372-wzwpyvll	27	11	giving	give	VBG
cord-000372-wzwpyvll	27	12	rise	rise	NN
cord-000372-wzwpyvll	27	13	to	to	IN
cord-000372-wzwpyvll	27	14	cell	cell	NN
cord-000372-wzwpyvll	27	15	rounding	rounding	NN
cord-000372-wzwpyvll	27	16	,	,	,
cord-000372-wzwpyvll	27	17	which	which	WDT
cord-000372-wzwpyvll	27	18	is	be	VBZ
cord-000372-wzwpyvll	27	19	most	most	RBS
cord-000372-wzwpyvll	27	20	probably	probably	RB
cord-000372-wzwpyvll	27	21	induced	induce	VBN
cord-000372-wzwpyvll	27	22	by	by	IN
cord-000372-wzwpyvll	27	23	disorders	disorder	NNS
cord-000372-wzwpyvll	27	24	in	in	IN
cord-000372-wzwpyvll	27	25	the	the	DT
cord-000372-wzwpyvll	27	26	cytoskeletal	cytoskeletal	JJ
cord-000372-wzwpyvll	27	27	network	network	NN
cord-000372-wzwpyvll	27	28	[	[	-LRB-
cord-000372-wzwpyvll	27	29	11	11	CD
cord-000372-wzwpyvll	27	30	]	]	-RRB-
cord-000372-wzwpyvll	27	31	.	.	.
cord-000372-wzwpyvll	28	1	Finally	finally	RB
cord-000372-wzwpyvll	28	2	,	,	,
cord-000372-wzwpyvll	28	3	chromatin	chromatin	NN
cord-000372-wzwpyvll	28	4	condensates	condensate	NNS
cord-000372-wzwpyvll	28	5	at	at	IN
cord-000372-wzwpyvll	28	6	late	late	JJ
cord-000372-wzwpyvll	28	7	times	time	NNS
cord-000372-wzwpyvll	28	8	postinfection	postinfection	NN
cord-000372-wzwpyvll	28	9	,	,	,
cord-000372-wzwpyvll	28	10	associated	associate	VBN
cord-000372-wzwpyvll	28	11	with	with	IN
cord-000372-wzwpyvll	28	12	the	the	DT
cord-000372-wzwpyvll	28	13	nuclear	nuclear	JJ
cord-000372-wzwpyvll	28	14	envelope	envelope	NN
cord-000372-wzwpyvll	28	15	except	except	IN
cord-000372-wzwpyvll	28	16	for	for	IN
cord-000372-wzwpyvll	28	17	sites	site	NNS
cord-000372-wzwpyvll	28	18	where	where	WRB
cord-000372-wzwpyvll	28	19	nuclear	nuclear	JJ
cord-000372-wzwpyvll	28	20	pores	pore	NNS
cord-000372-wzwpyvll	28	21	are	be	VBP
cord-000372-wzwpyvll	28	22	placed	place	VBN
cord-000372-wzwpyvll	28	23	[	[	-LRB-
cord-000372-wzwpyvll	28	24	11	11	CD
cord-000372-wzwpyvll	28	25	]	]	-RRB-
cord-000372-wzwpyvll	28	26	.	.	.
cord-000372-wzwpyvll	29	1	Interestingly	interestingly	RB
cord-000372-wzwpyvll	29	2	,	,	,
cord-000372-wzwpyvll	29	3	individual	individual	JJ
cord-000372-wzwpyvll	29	4	expression	expression	NN
cord-000372-wzwpyvll	29	5	of	of	IN
cord-000372-wzwpyvll	29	6	the	the	DT
cord-000372-wzwpyvll	29	7	viral	viral	JJ
cord-000372-wzwpyvll	29	8	proteases	protease	NNS
cord-000372-wzwpyvll	29	9	2A	2a	CD
cord-000372-wzwpyvll	29	10	pro	pro	NNP
cord-000372-wzwpyvll	29	11	and	and	CC
cord-000372-wzwpyvll	29	12	3C	3C	NNP
cord-000372-wzwpyvll	29	13	pro	pro	NNP
cord-000372-wzwpyvll	29	14	leads	lead	VBZ
cord-000372-wzwpyvll	29	15	to	to	IN
cord-000372-wzwpyvll	29	16	the	the	DT
cord-000372-wzwpyvll	29	17	induction	induction	NN
cord-000372-wzwpyvll	29	18	of	of	IN
cord-000372-wzwpyvll	29	19	most	most	JJS
cord-000372-wzwpyvll	29	20	of	of	IN
cord-000372-wzwpyvll	29	21	these	these	DT
cord-000372-wzwpyvll	29	22	cytopathic	cytopathic	JJ
cord-000372-wzwpyvll	29	23	effects	effect	NNS
cord-000372-wzwpyvll	29	24	,	,	,
cord-000372-wzwpyvll	29	25	supporting	support	VBG
cord-000372-wzwpyvll	29	26	the	the	DT
cord-000372-wzwpyvll	29	27	idea	idea	NN
cord-000372-wzwpyvll	29	28	that	that	IN
cord-000372-wzwpyvll	29	29	these	these	DT
cord-000372-wzwpyvll	29	30	proteases	protease	NNS
cord-000372-wzwpyvll	29	31	actively	actively	RB
cord-000372-wzwpyvll	29	32	contribute	contribute	VBP
cord-000372-wzwpyvll	29	33	to	to	IN
cord-000372-wzwpyvll	29	34	the	the	DT
cord-000372-wzwpyvll	29	35	viral	viral	RB
cord-000372-wzwpyvll	29	36	-	-	HYPH
cord-000372-wzwpyvll	29	37	induced	induce	VBN
cord-000372-wzwpyvll	29	38	morphological	morphological	JJ
cord-000372-wzwpyvll	29	39	changes	change	NNS
cord-000372-wzwpyvll	29	40	[	[	-LRB-
cord-000372-wzwpyvll	29	41	12	12	CD
cord-000372-wzwpyvll	29	42	]	]	-RRB-
cord-000372-wzwpyvll	29	43	.	.	.
cord-000372-wzwpyvll	30	1	Indeed	indeed	RB
cord-000372-wzwpyvll	30	2	,	,	,
cord-000372-wzwpyvll	30	3	long	long	JJ
cord-000372-wzwpyvll	30	4	-	-	HYPH
cord-000372-wzwpyvll	30	5	term	term	NN
cord-000372-wzwpyvll	30	6	expression	expression	NN
cord-000372-wzwpyvll	30	7	of	of	IN
cord-000372-wzwpyvll	30	8	either	either	DT
cord-000372-wzwpyvll	30	9	2A	2a	CD
cord-000372-wzwpyvll	30	10	pro	pro	JJ
cord-000372-wzwpyvll	30	11	or	or	CC
cord-000372-wzwpyvll	30	12	3C	3c	NN
cord-000372-wzwpyvll	30	13	pro	pro	NNP
cord-000372-wzwpyvll	30	14	triggers	trigger	VBZ
cord-000372-wzwpyvll	30	15	the	the	DT
cord-000372-wzwpyvll	30	16	activation	activation	NN
cord-000372-wzwpyvll	30	17	of	of	IN
cord-000372-wzwpyvll	30	18	caspases	caspase	NNS
cord-000372-wzwpyvll	30	19	and	and	CC
cord-000372-wzwpyvll	30	20	,	,	,
cord-000372-wzwpyvll	30	21	thus	thus	RB
cord-000372-wzwpyvll	30	22	,	,	,
cord-000372-wzwpyvll	30	23	cell	cell	NN
cord-000372-wzwpyvll	30	24	death	death	NN
cord-000372-wzwpyvll	30	25	by	by	IN
cord-000372-wzwpyvll	30	26	apoptosis	apoptosis	NN
cord-000372-wzwpyvll	30	27	[	[	-LRB-
cord-000372-wzwpyvll	30	28	11	11	CD
cord-000372-wzwpyvll	30	29	,	,	,
cord-000372-wzwpyvll	30	30	12	12	CD
cord-000372-wzwpyvll	30	31	]	]	-RRB-
cord-000372-wzwpyvll	30	32	,	,	,
cord-000372-wzwpyvll	30	33	reflecting	reflect	VBG
cord-000372-wzwpyvll	30	34	the	the	DT
cord-000372-wzwpyvll	30	35	strong	strong	JJ
cord-000372-wzwpyvll	30	36	cytotoxicity	cytotoxicity	NN
cord-000372-wzwpyvll	30	37	of	of	IN
cord-000372-wzwpyvll	30	38	both	both	DT
cord-000372-wzwpyvll	30	39	proteases	protease	NNS
cord-000372-wzwpyvll	30	40	.	.	.
cord-000372-wzwpyvll	31	1	In	in	IN
cord-000372-wzwpyvll	31	2	addition	addition	NN
cord-000372-wzwpyvll	31	3	to	to	IN
cord-000372-wzwpyvll	31	4	the	the	DT
cord-000372-wzwpyvll	31	5	cytopathic	cytopathic	JJ
cord-000372-wzwpyvll	31	6	effects	effect	NNS
cord-000372-wzwpyvll	31	7	induced	induce	VBN
cord-000372-wzwpyvll	31	8	by	by	IN
cord-000372-wzwpyvll	31	9	2A	2a	CD
cord-000372-wzwpyvll	31	10	pro	pro	NNP
cord-000372-wzwpyvll	31	11	and	and	CC
cord-000372-wzwpyvll	31	12	3C	3C	NNP
cord-000372-wzwpyvll	31	13	pro	pro	NNP
cord-000372-wzwpyvll	31	14	,	,	,
cord-000372-wzwpyvll	31	15	hydrolysis	hydrolysis	NN
cord-000372-wzwpyvll	31	16	of	of	IN
cord-000372-wzwpyvll	31	17	host	host	NN
cord-000372-wzwpyvll	31	18	proteins	protein	NNS
cord-000372-wzwpyvll	31	19	may	may	MD
cord-000372-wzwpyvll	31	20	impact	impact	VB
cord-000372-wzwpyvll	31	21	on	on	IN
cord-000372-wzwpyvll	31	22	other	other	JJ
cord-000372-wzwpyvll	31	23	cellular	cellular	JJ
cord-000372-wzwpyvll	31	24	functions	function	NNS
cord-000372-wzwpyvll	31	25	such	such	JJ
cord-000372-wzwpyvll	31	26	as	as	IN
cord-000372-wzwpyvll	31	27	the	the	DT
cord-000372-wzwpyvll	31	28	antiviral	antiviral	JJ
cord-000372-wzwpyvll	31	29	responses	response	NNS
cord-000372-wzwpyvll	31	30	to	to	IN
cord-000372-wzwpyvll	31	31	virus	virus	NN
cord-000372-wzwpyvll	31	32	infection	infection	NN
cord-000372-wzwpyvll	31	33	.	.	.
cord-000372-wzwpyvll	32	1	Activation	activation	NN
cord-000372-wzwpyvll	32	2	of	of	IN
cord-000372-wzwpyvll	32	3	innate	innate	JJ
cord-000372-wzwpyvll	32	4	immunity	immunity	NN
cord-000372-wzwpyvll	32	5	pathways	pathway	NNS
cord-000372-wzwpyvll	32	6	,	,	,
cord-000372-wzwpyvll	32	7	as	as	RB
cord-000372-wzwpyvll	32	8	well	well	RB
cord-000372-wzwpyvll	32	9	as	as	IN
cord-000372-wzwpyvll	32	10	the	the	DT
cord-000372-wzwpyvll	32	11	establishment	establishment	NN
cord-000372-wzwpyvll	32	12	of	of	IN
cord-000372-wzwpyvll	32	13	an	an	DT
cord-000372-wzwpyvll	32	14	antiviral	antiviral	JJ
cord-000372-wzwpyvll	32	15	response	response	NN
cord-000372-wzwpyvll	32	16	,	,	,
cord-000372-wzwpyvll	32	17	is	be	VBZ
cord-000372-wzwpyvll	32	18	absolutely	absolutely	RB
cord-000372-wzwpyvll	32	19	dependent	dependent	JJ
cord-000372-wzwpyvll	32	20	on	on	IN
cord-000372-wzwpyvll	32	21	signals	signal	NNS
cord-000372-wzwpyvll	32	22	traversing	traverse	VBG
cord-000372-wzwpyvll	32	23	the	the	DT
cord-000372-wzwpyvll	32	24	nuclear	nuclear	JJ
cord-000372-wzwpyvll	32	25	membrane	membrane	NN
cord-000372-wzwpyvll	32	26	through	through	IN
cord-000372-wzwpyvll	32	27	the	the	DT
cord-000372-wzwpyvll	32	28	nuclear	nuclear	JJ
cord-000372-wzwpyvll	32	29	pore	pore	NN
cord-000372-wzwpyvll	32	30	complex	complex	NN
cord-000372-wzwpyvll	32	31	.	.	.
cord-000372-wzwpyvll	33	1	Therefore	therefore	RB
cord-000372-wzwpyvll	33	2	,	,	,
cord-000372-wzwpyvll	33	3	many	many	JJ
cord-000372-wzwpyvll	33	4	viruses	virus	NNS
cord-000372-wzwpyvll	33	5	block	block	VBP
cord-000372-wzwpyvll	33	6	cellular	cellular	JJ
cord-000372-wzwpyvll	33	7	gene	gene	NN
cord-000372-wzwpyvll	33	8	expression	expression	NN
cord-000372-wzwpyvll	33	9	at	at	IN
cord-000372-wzwpyvll	33	10	different	different	JJ
cord-000372-wzwpyvll	33	11	levels	level	NNS
cord-000372-wzwpyvll	33	12	,	,	,
cord-000372-wzwpyvll	33	13	that	that	RB
cord-000372-wzwpyvll	33	14	is	is	RB
cord-000372-wzwpyvll	33	15	,	,	,
cord-000372-wzwpyvll	33	16	translation	translation	NN
cord-000372-wzwpyvll	33	17	,	,	,
cord-000372-wzwpyvll	33	18	transcription	transcription	NN
cord-000372-wzwpyvll	33	19	or	or	CC
cord-000372-wzwpyvll	33	20	protein	protein	NN
cord-000372-wzwpyvll	33	21	and	and	CC
cord-000372-wzwpyvll	33	22	RNA	RNA	NNP
cord-000372-wzwpyvll	33	23	trafficking	trafficking	NN
cord-000372-wzwpyvll	33	24	between	between	IN
cord-000372-wzwpyvll	33	25	nucleus	nucleus	NN
cord-000372-wzwpyvll	33	26	and	and	CC
cord-000372-wzwpyvll	33	27	cytoplasm	cytoplasm	JJ
cord-000372-wzwpyvll	33	28	.	.	.
cord-000372-wzwpyvll	34	1	The	the	DT
cord-000372-wzwpyvll	34	2	blockade	blockade	NN
cord-000372-wzwpyvll	34	3	of	of	IN
cord-000372-wzwpyvll	34	4	active	active	JJ
cord-000372-wzwpyvll	34	5	trafficking	trafficking	NN
cord-000372-wzwpyvll	34	6	can	can	MD
cord-000372-wzwpyvll	34	7	inhibit	inhibit	VB
cord-000372-wzwpyvll	34	8	the	the	DT
cord-000372-wzwpyvll	34	9	nuclear	nuclear	JJ
cord-000372-wzwpyvll	34	10	import	import	NN
cord-000372-wzwpyvll	34	11	of	of	IN
cord-000372-wzwpyvll	34	12	antiviral	antiviral	JJ
cord-000372-wzwpyvll	34	13	signals	signal	NNS
cord-000372-wzwpyvll	34	14	or	or	CC
cord-000372-wzwpyvll	34	15	prevent	prevent	VB
cord-000372-wzwpyvll	34	16	the	the	DT
cord-000372-wzwpyvll	34	17	export	export	NN
cord-000372-wzwpyvll	34	18	of	of	IN
cord-000372-wzwpyvll	34	19	cellular	cellular	JJ
cord-000372-wzwpyvll	34	20	mRNAs	mrna	NNS
cord-000372-wzwpyvll	34	21	detrimental	detrimental	JJ
cord-000372-wzwpyvll	34	22	to	to	IN
cord-000372-wzwpyvll	34	23	virus	virus	NN
cord-000372-wzwpyvll	34	24	processes	process	NNS
cord-000372-wzwpyvll	34	25	.	.	.
cord-000372-wzwpyvll	35	1	All	all	PDT
cord-000372-wzwpyvll	35	2	these	these	DT
cord-000372-wzwpyvll	35	3	effects	effect	NNS
cord-000372-wzwpyvll	35	4	can	can	MD
cord-000372-wzwpyvll	35	5	be	be	VB
cord-000372-wzwpyvll	35	6	achieved	achieve	VBN
cord-000372-wzwpyvll	35	7	by	by	IN
cord-000372-wzwpyvll	35	8	hydrolysis	hydrolysis	NN
cord-000372-wzwpyvll	35	9	of	of	IN
cord-000372-wzwpyvll	35	10	specific	specific	JJ
cord-000372-wzwpyvll	35	11	cellular	cellular	JJ
cord-000372-wzwpyvll	35	12	proteins	protein	NNS
cord-000372-wzwpyvll	35	13	.	.	.
cord-000372-wzwpyvll	36	1	The	the	DT
cord-000372-wzwpyvll	36	2	precise	precise	JJ
cord-000372-wzwpyvll	36	3	number	number	NN
cord-000372-wzwpyvll	36	4	of	of	IN
cord-000372-wzwpyvll	36	5	cellular	cellular	JJ
cord-000372-wzwpyvll	36	6	proteins	protein	NNS
cord-000372-wzwpyvll	36	7	degraded	degrade	VBN
cord-000372-wzwpyvll	36	8	by	by	IN
cord-000372-wzwpyvll	36	9	a	a	DT
cord-000372-wzwpyvll	36	10	viral	viral	JJ
cord-000372-wzwpyvll	36	11	protease	protease	NN
cord-000372-wzwpyvll	36	12	,	,	,
cord-000372-wzwpyvll	36	13	which	which	WDT
cord-000372-wzwpyvll	36	14	is	be	VBZ
cord-000372-wzwpyvll	36	15	known	know	VBN
cord-000372-wzwpyvll	36	16	as	as	IN
cord-000372-wzwpyvll	36	17	the	the	DT
cord-000372-wzwpyvll	36	18	"	"	``
cord-000372-wzwpyvll	36	19	degradome	degradome	NN
cord-000372-wzwpyvll	36	20	,	,	,
cord-000372-wzwpyvll	36	21	"	"	''
cord-000372-wzwpyvll	36	22	still	still	RB
cord-000372-wzwpyvll	36	23	remains	remain	VBZ
cord-000372-wzwpyvll	36	24	unknown	unknown	JJ
cord-000372-wzwpyvll	36	25	for	for	IN
cord-000372-wzwpyvll	36	26	a	a	DT
cord-000372-wzwpyvll	36	27	given	give	VBN
cord-000372-wzwpyvll	36	28	viral	viral	JJ
cord-000372-wzwpyvll	36	29	protease	protease	NN
cord-000372-wzwpyvll	36	30	.	.	.
cord-000372-wzwpyvll	37	1	Perhaps	perhaps	RB
cord-000372-wzwpyvll	37	2	,	,	,
cord-000372-wzwpyvll	37	3	one	one	CD
cord-000372-wzwpyvll	37	4	of	of	IN
cord-000372-wzwpyvll	37	5	the	the	DT
cord-000372-wzwpyvll	37	6	beststudied	beststudied	JJ
cord-000372-wzwpyvll	37	7	proteases	protease	NNS
cord-000372-wzwpyvll	37	8	in	in	IN
cord-000372-wzwpyvll	37	9	this	this	DT
cord-000372-wzwpyvll	37	10	respect	respect	NN
cord-000372-wzwpyvll	37	11	is	be	VBZ
cord-000372-wzwpyvll	37	12	PV	PV	NNP
cord-000372-wzwpyvll	37	13	2A	2a	CD
cord-000372-wzwpyvll	37	14	pro	pro	JJ
cord-000372-wzwpyvll	37	15	.	.	.
cord-000372-wzwpyvll	38	1	The	the	DT
cord-000372-wzwpyvll	38	2	discovery	discovery	NN
cord-000372-wzwpyvll	38	3	that	that	WDT
cord-000372-wzwpyvll	38	4	PV	PV	NNP
cord-000372-wzwpyvll	38	5	2A	2a	NN
cord-000372-wzwpyvll	38	6	pro	pro	NNP
cord-000372-wzwpyvll	38	7	bisects	bisect	VBZ
cord-000372-wzwpyvll	38	8	the	the	DT
cord-000372-wzwpyvll	38	9	initiation	initiation	NN
cord-000372-wzwpyvll	38	10	factor	factor	NN
cord-000372-wzwpyvll	38	11	of	of	IN
cord-000372-wzwpyvll	38	12	translation	translation	NN
cord-000372-wzwpyvll	39	1	eIF4	eif4	IN
cord-000372-wzwpyvll	39	2	G	G	NNP
cord-000372-wzwpyvll	39	3	leading	lead	VBG
cord-000372-wzwpyvll	39	4	to	to	IN
cord-000372-wzwpyvll	39	5	the	the	DT
cord-000372-wzwpyvll	39	6	regulation	regulation	NN
cord-000372-wzwpyvll	39	7	of	of	IN
cord-000372-wzwpyvll	39	8	translation	translation	NN
cord-000372-wzwpyvll	39	9	in	in	IN
cord-000372-wzwpyvll	39	10	the	the	DT
cord-000372-wzwpyvll	39	11	infected	infected	JJ
cord-000372-wzwpyvll	39	12	cells	cell	NNS
cord-000372-wzwpyvll	39	13	has	have	VBZ
cord-000372-wzwpyvll	39	14	attracted	attract	VBN
cord-000372-wzwpyvll	39	15	much	much	JJ
cord-000372-wzwpyvll	39	16	attention	attention	NN
cord-000372-wzwpyvll	39	17	from	from	IN
cord-000372-wzwpyvll	39	18	many	many	JJ
cord-000372-wzwpyvll	39	19	laboratories	laboratory	NNS
cord-000372-wzwpyvll	39	20	during	during	IN
cord-000372-wzwpyvll	39	21	the	the	DT
cord-000372-wzwpyvll	39	22	past	past	JJ
cord-000372-wzwpyvll	39	23	three	three	CD
cord-000372-wzwpyvll	39	24	decades	decade	NNS
cord-000372-wzwpyvll	39	25	[	[	-LRB-
cord-000372-wzwpyvll	39	26	13	13	CD
cord-000372-wzwpyvll	39	27	,	,	,
cord-000372-wzwpyvll	39	28	14	14	CD
cord-000372-wzwpyvll	39	29	]	]	-RRB-
cord-000372-wzwpyvll	39	30	.	.	.
cord-000372-wzwpyvll	40	1	More	more	RBR
cord-000372-wzwpyvll	40	2	recently	recently	RB
cord-000372-wzwpyvll	40	3	,	,	,
cord-000372-wzwpyvll	40	4	2A	2a	CD
cord-000372-wzwpyvll	40	5	pro	pro	NNP
cord-000372-wzwpyvll	40	6	has	have	VBZ
cord-000372-wzwpyvll	40	7	been	be	VBN
cord-000372-wzwpyvll	40	8	involved	involve	VBN
cord-000372-wzwpyvll	40	9	in	in	IN
cord-000372-wzwpyvll	40	10	the	the	DT
cord-000372-wzwpyvll	40	11	alteration	alteration	NN
cord-000372-wzwpyvll	40	12	of	of	IN
cord-000372-wzwpyvll	40	13	RNA	RNA	NNP
cord-000372-wzwpyvll	40	14	and	and	CC
cord-000372-wzwpyvll	40	15	protein	protein	NN
cord-000372-wzwpyvll	40	16	trafficking	trafficking	NN
cord-000372-wzwpyvll	40	17	between	between	IN
cord-000372-wzwpyvll	40	18	the	the	DT
cord-000372-wzwpyvll	40	19	nucleus	nucleus	NN
cord-000372-wzwpyvll	40	20	and	and	CC
cord-000372-wzwpyvll	40	21	the	the	DT
cord-000372-wzwpyvll	40	22	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	40	23	upon	upon	IN
cord-000372-wzwpyvll	40	24	proteolysis	proteolysis	NN
cord-000372-wzwpyvll	40	25	of	of	IN
cord-000372-wzwpyvll	40	26	several	several	JJ
cord-000372-wzwpyvll	40	27	nucleoporins	nucleoporin	NNS
cord-000372-wzwpyvll	40	28	[	[	-LRB-
cord-000372-wzwpyvll	40	29	15	15	CD
cord-000372-wzwpyvll	40	30	]	]	-RRB-
cord-000372-wzwpyvll	40	31	[	[	-LRB-
cord-000372-wzwpyvll	40	32	16	16	CD
cord-000372-wzwpyvll	40	33	]	]	-RRB-
cord-000372-wzwpyvll	40	34	[	[	-LRB-
cord-000372-wzwpyvll	40	35	17	17	CD
cord-000372-wzwpyvll	40	36	]	]	-RRB-
cord-000372-wzwpyvll	40	37	.	.	.
cord-000372-wzwpyvll	41	1	The	the	DT
cord-000372-wzwpyvll	41	2	present	present	JJ
cord-000372-wzwpyvll	41	3	paper	paper	NN
cord-000372-wzwpyvll	41	4	focuses	focus	VBZ
cord-000372-wzwpyvll	41	5	on	on	IN
cord-000372-wzwpyvll	41	6	the	the	DT
cord-000372-wzwpyvll	41	7	multifaceted	multifaceted	JJ
cord-000372-wzwpyvll	41	8	activities	activity	NNS
cord-000372-wzwpyvll	41	9	of	of	IN
cord-000372-wzwpyvll	41	10	2A	2a	CD
cord-000372-wzwpyvll	41	11	pro	pro	NNP
cord-000372-wzwpyvll	41	12	and	and	CC
cord-000372-wzwpyvll	41	13	its	-PRON-	PRP$
cord-000372-wzwpyvll	41	14	regulation	regulation	NN
cord-000372-wzwpyvll	41	15	of	of	IN
cord-000372-wzwpyvll	41	16	different	different	JJ
cord-000372-wzwpyvll	41	17	viral	viral	JJ
cord-000372-wzwpyvll	41	18	and	and	CC
cord-000372-wzwpyvll	41	19	cellular	cellular	JJ
cord-000372-wzwpyvll	41	20	processes	process	NNS
cord-000372-wzwpyvll	41	21	.	.	.
cord-000372-wzwpyvll	42	1	PV	PV	NNP
cord-000372-wzwpyvll	42	2	is	be	VBZ
cord-000372-wzwpyvll	42	3	a	a	DT
cord-000372-wzwpyvll	42	4	prototype	prototype	NN
cord-000372-wzwpyvll	42	5	member	member	NN
cord-000372-wzwpyvll	42	6	of	of	IN
cord-000372-wzwpyvll	42	7	the	the	DT
cord-000372-wzwpyvll	42	8	Picornaviridae	Picornaviridae	NNP
cord-000372-wzwpyvll	42	9	family	family	NN
cord-000372-wzwpyvll	42	10	that	that	WDT
cord-000372-wzwpyvll	42	11	infects	infect	VBZ
cord-000372-wzwpyvll	42	12	cells	cell	NNS
cord-000372-wzwpyvll	42	13	of	of	IN
cord-000372-wzwpyvll	42	14	human	human	JJ
cord-000372-wzwpyvll	42	15	or	or	CC
cord-000372-wzwpyvll	42	16	simian	simian	JJ
cord-000372-wzwpyvll	42	17	origin	origin	NN
cord-000372-wzwpyvll	42	18	cytolytically	cytolytically	RB
cord-000372-wzwpyvll	42	19	or	or	CC
cord-000372-wzwpyvll	42	20	persistently	persistently	RB
cord-000372-wzwpyvll	42	21	and	and	CC
cord-000372-wzwpyvll	42	22	is	be	VBZ
cord-000372-wzwpyvll	42	23	responsible	responsible	JJ
cord-000372-wzwpyvll	42	24	for	for	IN
cord-000372-wzwpyvll	42	25	poliomyelitis	poliomyelitis	NN
cord-000372-wzwpyvll	42	26	in	in	IN
cord-000372-wzwpyvll	42	27	humans	human	NNS
cord-000372-wzwpyvll	42	28	[	[	-LRB-
cord-000372-wzwpyvll	42	29	18	18	CD
cord-000372-wzwpyvll	42	30	]	]	-RRB-
cord-000372-wzwpyvll	42	31	.	.	.
cord-000372-wzwpyvll	43	1	The	the	DT
cord-000372-wzwpyvll	43	2	RNA	RNA	NNP
cord-000372-wzwpyvll	43	3	genome	genome	NN
cord-000372-wzwpyvll	43	4	is	be	VBZ
cord-000372-wzwpyvll	43	5	housed	house	VBN
cord-000372-wzwpyvll	43	6	in	in	IN
cord-000372-wzwpyvll	43	7	a	a	DT
cord-000372-wzwpyvll	43	8	naked	naked	JJ
cord-000372-wzwpyvll	43	9	capsid	capsid	NN
cord-000372-wzwpyvll	43	10	formed	form	VBN
cord-000372-wzwpyvll	43	11	by	by	IN
cord-000372-wzwpyvll	43	12	60	60	CD
cord-000372-wzwpyvll	43	13	copies	copy	NNS
cord-000372-wzwpyvll	43	14	of	of	IN
cord-000372-wzwpyvll	43	15	each	each	DT
cord-000372-wzwpyvll	43	16	of	of	IN
cord-000372-wzwpyvll	43	17	the	the	DT
cord-000372-wzwpyvll	43	18	four	four	CD
cord-000372-wzwpyvll	43	19	structural	structural	JJ
cord-000372-wzwpyvll	43	20	proteins	protein	NNS
cord-000372-wzwpyvll	43	21	:	:	:
cord-000372-wzwpyvll	43	22	VP1	VP1	NNP
cord-000372-wzwpyvll	43	23	,	,	,
cord-000372-wzwpyvll	43	24	VP2	vp2	NN
cord-000372-wzwpyvll	43	25	,	,	,
cord-000372-wzwpyvll	43	26	VP3	VP3	NNP
cord-000372-wzwpyvll	43	27	,	,	,
cord-000372-wzwpyvll	43	28	and	and	CC
cord-000372-wzwpyvll	43	29	VP4	VP4	NNP
cord-000372-wzwpyvll	43	30	.	.	.
cord-000372-wzwpyvll	44	1	The	the	DT
cord-000372-wzwpyvll	44	2	infectious	infectious	JJ
cord-000372-wzwpyvll	44	3	cycle	cycle	NN
cord-000372-wzwpyvll	44	4	commences	commence	VBZ
cord-000372-wzwpyvll	44	5	by	by	IN
cord-000372-wzwpyvll	44	6	the	the	DT
cord-000372-wzwpyvll	44	7	attachment	attachment	NN
cord-000372-wzwpyvll	44	8	of	of	IN
cord-000372-wzwpyvll	44	9	a	a	DT
cord-000372-wzwpyvll	44	10	viral	viral	JJ
cord-000372-wzwpyvll	44	11	particle	particle	NN
cord-000372-wzwpyvll	44	12	to	to	IN
cord-000372-wzwpyvll	44	13	cellular	cellular	JJ
cord-000372-wzwpyvll	44	14	receptors	receptor	NNS
cord-000372-wzwpyvll	44	15	present	present	JJ
cord-000372-wzwpyvll	44	16	at	at	IN
cord-000372-wzwpyvll	44	17	the	the	DT
cord-000372-wzwpyvll	44	18	cell	cell	NN
cord-000372-wzwpyvll	44	19	surface	surface	NN
cord-000372-wzwpyvll	44	20	[	[	-LRB-
cord-000372-wzwpyvll	44	21	19	19	CD
cord-000372-wzwpyvll	44	22	,	,	,
cord-000372-wzwpyvll	44	23	20	20	CD
cord-000372-wzwpyvll	44	24	]	]	-RRB-
cord-000372-wzwpyvll	44	25	.	.	.
cord-000372-wzwpyvll	45	1	This	this	DT
cord-000372-wzwpyvll	45	2	interaction	interaction	NN
cord-000372-wzwpyvll	45	3	leads	lead	VBZ
cord-000372-wzwpyvll	45	4	to	to	IN
cord-000372-wzwpyvll	45	5	virion	virion	NN
cord-000372-wzwpyvll	45	6	internalization	internalization	NN
cord-000372-wzwpyvll	45	7	and	and	CC
cord-000372-wzwpyvll	45	8	destabilization	destabilization	NN
cord-000372-wzwpyvll	45	9	of	of	IN
cord-000372-wzwpyvll	45	10	the	the	DT
cord-000372-wzwpyvll	45	11	capsid	capsid	NN
cord-000372-wzwpyvll	45	12	,	,	,
cord-000372-wzwpyvll	45	13	which	which	WDT
cord-000372-wzwpyvll	45	14	adopts	adopt	VBZ
cord-000372-wzwpyvll	45	15	a	a	DT
cord-000372-wzwpyvll	45	16	less	less	RBR
cord-000372-wzwpyvll	45	17	compact	compact	JJ
cord-000372-wzwpyvll	45	18	structure	structure	NN
cord-000372-wzwpyvll	45	19	.	.	.
cord-000372-wzwpyvll	46	1	Once	once	IN
cord-000372-wzwpyvll	46	2	the	the	DT
cord-000372-wzwpyvll	46	3	RNA	RNA	NNP
cord-000372-wzwpyvll	46	4	is	be	VBZ
cord-000372-wzwpyvll	46	5	released	release	VBN
cord-000372-wzwpyvll	46	6	in	in	IN
cord-000372-wzwpyvll	46	7	the	the	DT
cord-000372-wzwpyvll	46	8	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	46	9	,	,	,
cord-000372-wzwpyvll	46	10	it	-PRON-	PRP
cord-000372-wzwpyvll	46	11	interacts	interact	VBZ
cord-000372-wzwpyvll	46	12	with	with	IN
cord-000372-wzwpyvll	46	13	the	the	DT
cord-000372-wzwpyvll	46	14	translational	translational	JJ
cord-000372-wzwpyvll	46	15	machinery	machinery	NN
cord-000372-wzwpyvll	46	16	,	,	,
cord-000372-wzwpyvll	46	17	directing	direct	VBG
cord-000372-wzwpyvll	46	18	the	the	DT
cord-000372-wzwpyvll	46	19	synthesis	synthesis	NN
cord-000372-wzwpyvll	46	20	of	of	IN
cord-000372-wzwpyvll	46	21	viral	viral	JJ
cord-000372-wzwpyvll	46	22	proteins	protein	NNS
cord-000372-wzwpyvll	46	23	during	during	IN
cord-000372-wzwpyvll	46	24	the	the	DT
cord-000372-wzwpyvll	46	25	early	early	JJ
cord-000372-wzwpyvll	46	26	phase	phase	NN
cord-000372-wzwpyvll	46	27	of	of	IN
cord-000372-wzwpyvll	46	28	infection	infection	NN
cord-000372-wzwpyvll	46	29	.	.	.
cord-000372-wzwpyvll	47	1	The	the	DT
cord-000372-wzwpyvll	47	2	PV	PV	NNP
cord-000372-wzwpyvll	47	3	genome	genome	NN
cord-000372-wzwpyvll	47	4	is	be	VBZ
cord-000372-wzwpyvll	47	5	composed	compose	VBN
cord-000372-wzwpyvll	47	6	of	of	IN
cord-000372-wzwpyvll	47	7	a	a	DT
cord-000372-wzwpyvll	47	8	single	single	RB
cord-000372-wzwpyvll	47	9	-	-	HYPH
cord-000372-wzwpyvll	47	10	stranded	strand	VBN
cord-000372-wzwpyvll	47	11	RNA	RNA	NNP
cord-000372-wzwpyvll	47	12	copy	copy	NN
cord-000372-wzwpyvll	47	13	of	of	IN
cord-000372-wzwpyvll	47	14	positive	positive	JJ
cord-000372-wzwpyvll	47	15	polarity	polarity	NN
cord-000372-wzwpyvll	47	16	of	of	IN
cord-000372-wzwpyvll	47	17	about	about	IN
cord-000372-wzwpyvll	47	18	7.4	7.4	CD
cord-000372-wzwpyvll	47	19	Kb	Kb	NNP
cord-000372-wzwpyvll	47	20	[	[	-LRB-
cord-000372-wzwpyvll	47	21	21	21	CD
cord-000372-wzwpyvll	47	22	,	,	,
cord-000372-wzwpyvll	47	23	22	22	CD
cord-000372-wzwpyvll	47	24	]	]	-RRB-
cord-000372-wzwpyvll	47	25	.	.	.
cord-000372-wzwpyvll	48	1	This	this	DT
cord-000372-wzwpyvll	48	2	RNA	RNA	NNP
cord-000372-wzwpyvll	48	3	molecule	molecule	NN
cord-000372-wzwpyvll	48	4	is	be	VBZ
cord-000372-wzwpyvll	48	5	uncapped	uncapped	JJ
cord-000372-wzwpyvll	48	6	and	and	CC
cord-000372-wzwpyvll	48	7	contains	contain	VBZ
cord-000372-wzwpyvll	48	8	a	a	DT
cord-000372-wzwpyvll	48	9	poly(A	poly(a	JJ
cord-000372-wzwpyvll	48	10	)	)	-RRB-
cord-000372-wzwpyvll	48	11	tail	tail	NN
cord-000372-wzwpyvll	48	12	at	at	IN
cord-000372-wzwpyvll	48	13	its	-PRON-	PRP$
cord-000372-wzwpyvll	48	14	3	3	CD
cord-000372-wzwpyvll	48	15	end	end	NN
cord-000372-wzwpyvll	48	16	and	and	CC
cord-000372-wzwpyvll	48	17	a	a	DT
cord-000372-wzwpyvll	48	18	single	single	JJ
cord-000372-wzwpyvll	48	19	open	open	JJ
cord-000372-wzwpyvll	48	20	reading	reading	NN
cord-000372-wzwpyvll	48	21	frame	frame	NN
cord-000372-wzwpyvll	48	22	,	,	,
cord-000372-wzwpyvll	48	23	which	which	WDT
cord-000372-wzwpyvll	48	24	encodes	encode	VBZ
cord-000372-wzwpyvll	48	25	for	for	IN
cord-000372-wzwpyvll	48	26	a	a	DT
cord-000372-wzwpyvll	48	27	polyprotein	polyprotein	NN
cord-000372-wzwpyvll	48	28	of	of	IN
cord-000372-wzwpyvll	48	29	about	about	RB
cord-000372-wzwpyvll	48	30	two	two	CD
cord-000372-wzwpyvll	48	31	thousands	thousand	NNS
cord-000372-wzwpyvll	48	32	amino	amino	NN
cord-000372-wzwpyvll	48	33	acid	acid	NN
cord-000372-wzwpyvll	48	34	residues	residue	NNS
cord-000372-wzwpyvll	48	35	.	.	.
cord-000372-wzwpyvll	49	1	This	this	DT
cord-000372-wzwpyvll	49	2	polyprotein	polyprotein	NN
cord-000372-wzwpyvll	49	3	is	be	VBZ
cord-000372-wzwpyvll	49	4	proteolytically	proteolytically	RB
cord-000372-wzwpyvll	49	5	processed	process	VBN
cord-000372-wzwpyvll	49	6	giving	give	VBG
cord-000372-wzwpyvll	49	7	rise	rise	NN
cord-000372-wzwpyvll	49	8	to	to	IN
cord-000372-wzwpyvll	49	9	the	the	DT
cord-000372-wzwpyvll	49	10	mature	mature	JJ
cord-000372-wzwpyvll	49	11	viral	viral	JJ
cord-000372-wzwpyvll	49	12	proteins	protein	NNS
cord-000372-wzwpyvll	49	13	[	[	-LRB-
cord-000372-wzwpyvll	49	14	23	23	CD
cord-000372-wzwpyvll	49	15	]	]	-RRB-
cord-000372-wzwpyvll	50	1	(	(	-LRB-
cord-000372-wzwpyvll	50	2	Figure	figure	NN
cord-000372-wzwpyvll	50	3	1(a	1(a	CD
cord-000372-wzwpyvll	50	4	)	)	-RRB-
cord-000372-wzwpyvll	50	5	)	)	-RRB-
cord-000372-wzwpyvll	50	6	.	.	.
cord-000372-wzwpyvll	51	1	Three	three	CD
cord-000372-wzwpyvll	51	2	different	different	JJ
cord-000372-wzwpyvll	51	3	cleavages	cleavage	NNS
cord-000372-wzwpyvll	51	4	can	can	MD
cord-000372-wzwpyvll	51	5	be	be	VB
cord-000372-wzwpyvll	51	6	distinguished	distinguish	VBN
cord-000372-wzwpyvll	51	7	on	on	IN
cord-000372-wzwpyvll	51	8	the	the	DT
cord-000372-wzwpyvll	51	9	viral	viral	JJ
cord-000372-wzwpyvll	51	10	polyprotein	polyprotein	NN
cord-000372-wzwpyvll	51	11	:	:	:
cord-000372-wzwpyvll	51	12	(	(	-LRB-
cord-000372-wzwpyvll	51	13	i	i	NN
cord-000372-wzwpyvll	51	14	)	)	-RRB-
cord-000372-wzwpyvll	51	15	polysomal	polysomal	NN
cord-000372-wzwpyvll	51	16	cleavages	cleavage	NNS
cord-000372-wzwpyvll	51	17	that	that	WDT
cord-000372-wzwpyvll	51	18	are	be	VBP
cord-000372-wzwpyvll	51	19	produced	produce	VBN
cord-000372-wzwpyvll	51	20	on	on	IN
cord-000372-wzwpyvll	51	21	the	the	DT
cord-000372-wzwpyvll	51	22	nascent	nascent	JJ
cord-000372-wzwpyvll	51	23	polypeptide	polypeptide	NN
cord-000372-wzwpyvll	51	24	chain	chain	NN
cord-000372-wzwpyvll	51	25	.	.	.
cord-000372-wzwpyvll	52	1	The	the	DT
cord-000372-wzwpyvll	52	2	first	first	JJ
cord-000372-wzwpyvll	52	3	of	of	IN
cord-000372-wzwpyvll	52	4	these	these	DT
cord-000372-wzwpyvll	52	5	cleavages	cleavage	NNS
cord-000372-wzwpyvll	52	6	is	be	VBZ
cord-000372-wzwpyvll	52	7	catalyzed	catalyze	VBN
cord-000372-wzwpyvll	52	8	by	by	IN
cord-000372-wzwpyvll	52	9	2A	2a	CD
cord-000372-wzwpyvll	52	10	pro	pro	NNP
cord-000372-wzwpyvll	52	11	at	at	IN
cord-000372-wzwpyvll	52	12	its	-PRON-	PRP$
cord-000372-wzwpyvll	52	13	amino	amino	NN
cord-000372-wzwpyvll	52	14	terminus	terminus	NN
cord-000372-wzwpyvll	52	15	separating	separate	VBG
cord-000372-wzwpyvll	52	16	the	the	DT
cord-000372-wzwpyvll	52	17	P1	P1	NNP
cord-000372-wzwpyvll	52	18	precursor	precursor	NN
cord-000372-wzwpyvll	52	19	that	that	WDT
cord-000372-wzwpyvll	52	20	encodes	encode	VBZ
cord-000372-wzwpyvll	52	21	for	for	IN
cord-000372-wzwpyvll	52	22	the	the	DT
cord-000372-wzwpyvll	52	23	structural	structural	JJ
cord-000372-wzwpyvll	52	24	proteins	protein	NNS
cord-000372-wzwpyvll	52	25	from	from	IN
cord-000372-wzwpyvll	52	26	the	the	DT
cord-000372-wzwpyvll	52	27	rest	rest	NN
cord-000372-wzwpyvll	52	28	of	of	IN
cord-000372-wzwpyvll	52	29	nonstructural	nonstructural	JJ
cord-000372-wzwpyvll	52	30	polypeptides	polypeptide	NNS
cord-000372-wzwpyvll	52	31	(	(	-LRB-
cord-000372-wzwpyvll	52	32	Figure	figure	NN
cord-000372-wzwpyvll	52	33	1(b	1(b	CD
cord-000372-wzwpyvll	52	34	)	)	-RRB-
cord-000372-wzwpyvll	52	35	)	)	-RRB-
cord-000372-wzwpyvll	52	36	.	.	.
cord-000372-wzwpyvll	53	1	The	the	DT
cord-000372-wzwpyvll	53	2	second	second	JJ
cord-000372-wzwpyvll	53	3	cleavage	cleavage	NN
cord-000372-wzwpyvll	53	4	still	still	RB
cord-000372-wzwpyvll	53	5	on	on	IN
cord-000372-wzwpyvll	53	6	polysomes	polysome	NNS
cord-000372-wzwpyvll	53	7	is	be	VBZ
cord-000372-wzwpyvll	53	8	performed	perform	VBN
cord-000372-wzwpyvll	53	9	by	by	IN
cord-000372-wzwpyvll	53	10	3C	3C	NNP
cord-000372-wzwpyvll	53	11	pro	pro	NNP
cord-000372-wzwpyvll	53	12	,	,	,
cord-000372-wzwpyvll	53	13	releasing	release	VBG
cord-000372-wzwpyvll	53	14	the	the	DT
cord-000372-wzwpyvll	53	15	P2	P2	NNP
cord-000372-wzwpyvll	53	16	precursor	precursor	NN
cord-000372-wzwpyvll	53	17	(	(	-LRB-
cord-000372-wzwpyvll	53	18	2ABC	2abc	LS
cord-000372-wzwpyvll	53	19	)	)	-RRB-
cord-000372-wzwpyvll	53	20	from	from	IN
cord-000372-wzwpyvll	53	21	P3	P3	NNP
cord-000372-wzwpyvll	53	22	(	(	-LRB-
cord-000372-wzwpyvll	53	23	3ABCD	3abcd	CD
cord-000372-wzwpyvll	53	24	)	)	-RRB-
cord-000372-wzwpyvll	53	25	;	;	:
cord-000372-wzwpyvll	53	26	(	(	-LRB-
cord-000372-wzwpyvll	53	27	ii	ii	NN
cord-000372-wzwpyvll	53	28	)	)	-RRB-
cord-000372-wzwpyvll	53	29	cytoplasmic	cytoplasmic	JJ
cord-000372-wzwpyvll	53	30	cleavages	cleavage	NNS
cord-000372-wzwpyvll	53	31	that	that	WDT
cord-000372-wzwpyvll	53	32	are	be	VBP
cord-000372-wzwpyvll	53	33	mostly	mostly	RB
cord-000372-wzwpyvll	53	34	exerted	exert	VBN
cord-000372-wzwpyvll	53	35	by	by	IN
cord-000372-wzwpyvll	53	36	3C	3C	NNP
cord-000372-wzwpyvll	53	37	pro	pro	NNP
cord-000372-wzwpyvll	53	38	and	and	CC
cord-000372-wzwpyvll	53	39	(	(	-LRB-
cord-000372-wzwpyvll	53	40	iii	iii	NN
cord-000372-wzwpyvll	53	41	)	)	-RRB-
cord-000372-wzwpyvll	53	42	hydrolysis	hydrolysis	NN
cord-000372-wzwpyvll	53	43	of	of	IN
cord-000372-wzwpyvll	53	44	VP0	VP0	NNP
cord-000372-wzwpyvll	53	45	(	(	-LRB-
cord-000372-wzwpyvll	53	46	VP4-VP2	VP4-VP2	NNP
cord-000372-wzwpyvll	53	47	)	)	-RRB-
cord-000372-wzwpyvll	53	48	,	,	,
cord-000372-wzwpyvll	53	49	which	which	WDT
cord-000372-wzwpyvll	53	50	is	be	VBZ
cord-000372-wzwpyvll	53	51	concomitant	concomitant	JJ
cord-000372-wzwpyvll	53	52	with	with	IN
cord-000372-wzwpyvll	53	53	the	the	DT
cord-000372-wzwpyvll	53	54	morphogenesis	morphogenesis	NN
cord-000372-wzwpyvll	53	55	of	of	IN
cord-000372-wzwpyvll	53	56	virus	virus	NN
cord-000372-wzwpyvll	53	57	particles	particle	NNS
cord-000372-wzwpyvll	53	58	[	[	-LRB-
cord-000372-wzwpyvll	53	59	2	2	CD
cord-000372-wzwpyvll	53	60	,	,	,
cord-000372-wzwpyvll	53	61	23	23	CD
cord-000372-wzwpyvll	53	62	]	]	-RRB-
cord-000372-wzwpyvll	53	63	.	.	.
cord-000372-wzwpyvll	54	1	All	all	PDT
cord-000372-wzwpyvll	54	2	these	these	DT
cord-000372-wzwpyvll	54	3	hydrolytic	hydrolytic	JJ
cord-000372-wzwpyvll	54	4	events	event	NNS
cord-000372-wzwpyvll	54	5	lead	lead	VBP
cord-000372-wzwpyvll	54	6	to	to	IN
cord-000372-wzwpyvll	54	7	the	the	DT
cord-000372-wzwpyvll	54	8	formation	formation	NN
cord-000372-wzwpyvll	54	9	of	of	IN
cord-000372-wzwpyvll	54	10	eleven	eleven	CD
cord-000372-wzwpyvll	54	11	mature	mature	JJ
cord-000372-wzwpyvll	54	12	proteins	protein	NNS
cord-000372-wzwpyvll	54	13	and	and	CC
cord-000372-wzwpyvll	54	14	several	several	JJ
cord-000372-wzwpyvll	54	15	precursors	precursor	NNS
cord-000372-wzwpyvll	54	16	such	such	JJ
cord-000372-wzwpyvll	54	17	as	as	IN
cord-000372-wzwpyvll	54	18	P1	P1	NNP
cord-000372-wzwpyvll	54	19	,	,	,
cord-000372-wzwpyvll	54	20	P2	P2	NNP
cord-000372-wzwpyvll	54	21	,	,	,
cord-000372-wzwpyvll	54	22	P3	P3	NNP
cord-000372-wzwpyvll	54	23	,	,	,
cord-000372-wzwpyvll	54	24	VP0	VP0	NNP
cord-000372-wzwpyvll	54	25	,	,	,
cord-000372-wzwpyvll	54	26	VP3	VP3	NNP
cord-000372-wzwpyvll	54	27	,	,	,
cord-000372-wzwpyvll	54	28	VP1	VP1	NNP
cord-000372-wzwpyvll	54	29	,	,	,
cord-000372-wzwpyvll	54	30	2BC	2BC	NNP
cord-000372-wzwpyvll	54	31	,	,	,
cord-000372-wzwpyvll	54	32	3AB	3AB	NNP
cord-000372-wzwpyvll	54	33	,	,	,
cord-000372-wzwpyvll	54	34	and	and	CC
cord-000372-wzwpyvll	54	35	3CD	3cd	NN
cord-000372-wzwpyvll	54	36	.	.	.
cord-000372-wzwpyvll	55	1	This	this	DT
cord-000372-wzwpyvll	55	2	last	last	JJ
cord-000372-wzwpyvll	55	3	precursor	precursor	NN
cord-000372-wzwpyvll	55	4	,	,	,
cord-000372-wzwpyvll	55	5	3CD	3CD	NNP
cord-000372-wzwpyvll	55	6	,	,	,
cord-000372-wzwpyvll	55	7	can	can	MD
cord-000372-wzwpyvll	55	8	be	be	VB
cord-000372-wzwpyvll	55	9	used	use	VBN
cord-000372-wzwpyvll	55	10	as	as	IN
cord-000372-wzwpyvll	55	11	substrate	substrate	NN
cord-000372-wzwpyvll	55	12	by	by	IN
cord-000372-wzwpyvll	55	13	2A	2a	CD
cord-000372-wzwpyvll	55	14	pro	pro	NNP
cord-000372-wzwpyvll	55	15	or	or	CC
cord-000372-wzwpyvll	55	16	3C	3C	NNP
cord-000372-wzwpyvll	55	17	pro	pro	NNP
cord-000372-wzwpyvll	55	18	.	.	.
cord-000372-wzwpyvll	56	1	The	the	DT
cord-000372-wzwpyvll	56	2	alternative	alternative	JJ
cord-000372-wzwpyvll	56	3	cleavage	cleavage	NN
cord-000372-wzwpyvll	56	4	carried	carry	VBN
cord-000372-wzwpyvll	56	5	out	out	RP
cord-000372-wzwpyvll	56	6	by	by	IN
cord-000372-wzwpyvll	56	7	2A	2a	CD
cord-000372-wzwpyvll	56	8	pro	pro	NNP
cord-000372-wzwpyvll	56	9	renders	render	VBZ
cord-000372-wzwpyvll	56	10	the	the	DT
cord-000372-wzwpyvll	56	11	mature	mature	JJ
cord-000372-wzwpyvll	56	12	products	product	NNS
cord-000372-wzwpyvll	56	13	3C	3C	NNP
cord-000372-wzwpyvll	56	14	and	and	CC
cord-000372-wzwpyvll	56	15	3D	3D	NNP
cord-000372-wzwpyvll	56	16	,	,	,
cord-000372-wzwpyvll	56	17	whereas	whereas	IN
cord-000372-wzwpyvll	56	18	3C	3C	NNP
cord-000372-wzwpyvll	56	19	pro	pro	NNP
cord-000372-wzwpyvll	56	20	generates	generate	VBZ
cord-000372-wzwpyvll	56	21	the	the	DT
cord-000372-wzwpyvll	56	22	canonical	canonical	JJ
cord-000372-wzwpyvll	56	23	proteins	protein	NNS
cord-000372-wzwpyvll	56	24	3C	3C	NNP
cord-000372-wzwpyvll	56	25	pro	pro	NNP
cord-000372-wzwpyvll	56	26	and	and	CC
cord-000372-wzwpyvll	56	27	3D	3d	JJ
cord-000372-wzwpyvll	56	28	pol	pol	NN
cord-000372-wzwpyvll	56	29	.	.	.
cord-000372-wzwpyvll	57	1	However	however	RB
cord-000372-wzwpyvll	57	2	,	,	,
cord-000372-wzwpyvll	57	3	the	the	DT
cord-000372-wzwpyvll	57	4	biological	biological	JJ
cord-000372-wzwpyvll	57	5	significance	significance	NN
cord-000372-wzwpyvll	57	6	of	of	IN
cord-000372-wzwpyvll	57	7	this	this	DT
cord-000372-wzwpyvll	57	8	alternative	alternative	JJ
cord-000372-wzwpyvll	57	9	cleavage	cleavage	NN
cord-000372-wzwpyvll	57	10	is	be	VBZ
cord-000372-wzwpyvll	57	11	obscure	obscure	JJ
cord-000372-wzwpyvll	57	12	because	because	IN
cord-000372-wzwpyvll	57	13	PV	PV	NNP
cord-000372-wzwpyvll	57	14	mutated	mutate	VBN
cord-000372-wzwpyvll	57	15	at	at	IN
cord-000372-wzwpyvll	57	16	2A	2a	CD
cord-000372-wzwpyvll	57	17	pro	pro	NNP
cord-000372-wzwpyvll	57	18	-cleavage	-cleavage	NN
cord-000372-wzwpyvll	57	19	site	site	NN
cord-000372-wzwpyvll	57	20	on	on	IN
cord-000372-wzwpyvll	57	21	3CD	3CD	NNP
cord-000372-wzwpyvll	57	22	does	do	VBZ
cord-000372-wzwpyvll	57	23	not	not	RB
cord-000372-wzwpyvll	57	24	exhibit	exhibit	VB
cord-000372-wzwpyvll	57	25	defects	defect	NNS
cord-000372-wzwpyvll	57	26	in	in	IN
cord-000372-wzwpyvll	57	27	virus	virus	NN
cord-000372-wzwpyvll	57	28	replication	replication	NN
cord-000372-wzwpyvll	57	29	[	[	-LRB-
cord-000372-wzwpyvll	57	30	24	24	CD
cord-000372-wzwpyvll	57	31	]	]	-RRB-
cord-000372-wzwpyvll	57	32	.	.	.
cord-000372-wzwpyvll	58	1	The	the	DT
cord-000372-wzwpyvll	58	2	nonstructural	nonstructural	JJ
cord-000372-wzwpyvll	58	3	proteins	protein	NNS
cord-000372-wzwpyvll	58	4	that	that	WDT
cord-000372-wzwpyvll	58	5	are	be	VBP
cord-000372-wzwpyvll	58	6	generated	generate	VBN
cord-000372-wzwpyvll	58	7	participate	participate	VBP
cord-000372-wzwpyvll	58	8	in	in	IN
cord-000372-wzwpyvll	58	9	the	the	DT
cord-000372-wzwpyvll	58	10	replication	replication	NN
cord-000372-wzwpyvll	58	11	of	of	IN
cord-000372-wzwpyvll	58	12	viral	viral	JJ
cord-000372-wzwpyvll	58	13	genomes	genome	NNS
cord-000372-wzwpyvll	58	14	[	[	-LRB-
cord-000372-wzwpyvll	58	15	25	25	CD
cord-000372-wzwpyvll	58	16	,	,	,
cord-000372-wzwpyvll	58	17	26	26	CD
cord-000372-wzwpyvll	58	18	]	]	-RRB-
cord-000372-wzwpyvll	58	19	.	.	.
cord-000372-wzwpyvll	59	1	To	to	IN
cord-000372-wzwpyvll	59	2	this	this	DT
cord-000372-wzwpyvll	59	3	end	end	NN
cord-000372-wzwpyvll	59	4	,	,	,
cord-000372-wzwpyvll	59	5	the	the	DT
cord-000372-wzwpyvll	59	6	positive	positive	JJ
cord-000372-wzwpyvll	59	7	RNA	RNA	NNP
cord-000372-wzwpyvll	59	8	genome	genome	NN
cord-000372-wzwpyvll	59	9	is	be	VBZ
cord-000372-wzwpyvll	59	10	recognized	recognize	VBN
cord-000372-wzwpyvll	59	11	at	at	IN
cord-000372-wzwpyvll	59	12	its	-PRON-	PRP$
cord-000372-wzwpyvll	59	13	3	3	CD
cord-000372-wzwpyvll	59	14	end	end	NN
cord-000372-wzwpyvll	59	15	by	by	IN
cord-000372-wzwpyvll	59	16	proteins	protein	NNS
cord-000372-wzwpyvll	59	17	of	of	IN
cord-000372-wzwpyvll	59	18	the	the	DT
cord-000372-wzwpyvll	59	19	replication	replication	NN
cord-000372-wzwpyvll	59	20	complex	complex	NN
cord-000372-wzwpyvll	59	21	to	to	TO
cord-000372-wzwpyvll	59	22	synthesize	synthesize	VB
cord-000372-wzwpyvll	59	23	the	the	DT
cord-000372-wzwpyvll	59	24	complementary	complementary	JJ
cord-000372-wzwpyvll	59	25	RNA	RNA	NNP
cord-000372-wzwpyvll	59	26	strand	strand	NN
cord-000372-wzwpyvll	59	27	of	of	IN
cord-000372-wzwpyvll	59	28	negative	negative	JJ
cord-000372-wzwpyvll	59	29	polarity	polarity	NN
cord-000372-wzwpyvll	59	30	.	.	.
cord-000372-wzwpyvll	60	1	In	in	IN
cord-000372-wzwpyvll	60	2	this	this	DT
cord-000372-wzwpyvll	60	3	process	process	NN
cord-000372-wzwpyvll	60	4	,	,	,
cord-000372-wzwpyvll	60	5	3B	3B	NNP
cord-000372-wzwpyvll	60	6	protein	protein	NN
cord-000372-wzwpyvll	60	7	,	,	,
cord-000372-wzwpyvll	60	8	also	also	RB
cord-000372-wzwpyvll	60	9	known	know	VBN
cord-000372-wzwpyvll	60	10	as	as	IN
cord-000372-wzwpyvll	60	11	VPg	VPg	NNS
cord-000372-wzwpyvll	60	12	,	,	,
cord-000372-wzwpyvll	60	13	acts	act	VBZ
cord-000372-wzwpyvll	60	14	as	as	IN
cord-000372-wzwpyvll	60	15	a	a	DT
cord-000372-wzwpyvll	60	16	primer	primer	NN
cord-000372-wzwpyvll	60	17	to	to	TO
cord-000372-wzwpyvll	60	18	initiate	initiate	VB
cord-000372-wzwpyvll	60	19	viral	viral	JJ
cord-000372-wzwpyvll	60	20	RNA	rna	NN
cord-000372-wzwpyvll	60	21	transcription	transcription	NN
cord-000372-wzwpyvll	60	22	[	[	-LRB-
cord-000372-wzwpyvll	60	23	27	27	CD
cord-000372-wzwpyvll	60	24	]	]	-RRB-
cord-000372-wzwpyvll	60	25	.	.	.
cord-000372-wzwpyvll	61	1	This	this	DT
cord-000372-wzwpyvll	61	2	leads	lead	VBZ
cord-000372-wzwpyvll	61	3	to	to	IN
cord-000372-wzwpyvll	61	4	the	the	DT
cord-000372-wzwpyvll	61	5	formation	formation	NN
cord-000372-wzwpyvll	61	6	of	of	IN
cord-000372-wzwpyvll	61	7	a	a	DT
cord-000372-wzwpyvll	61	8	doublestranded	doublestranded	JJ
cord-000372-wzwpyvll	61	9	RNA	RNA	NNP
cord-000372-wzwpyvll	61	10	molecule	molecule	NN
cord-000372-wzwpyvll	61	11	,	,	,
cord-000372-wzwpyvll	61	12	also	also	RB
cord-000372-wzwpyvll	61	13	known	know	VBN
cord-000372-wzwpyvll	61	14	as	as	IN
cord-000372-wzwpyvll	61	15	the	the	DT
cord-000372-wzwpyvll	61	16	replicative	replicative	JJ
cord-000372-wzwpyvll	61	17	form	form	NN
cord-000372-wzwpyvll	61	18	.	.	.
cord-000372-wzwpyvll	62	1	The	the	DT
cord-000372-wzwpyvll	62	2	negative	negative	JJ
cord-000372-wzwpyvll	62	3	RNA	rna	NN
cord-000372-wzwpyvll	62	4	synthesized	synthesize	VBN
cord-000372-wzwpyvll	62	5	serves	serve	NNS
cord-000372-wzwpyvll	62	6	in	in	IN
cord-000372-wzwpyvll	62	7	turn	turn	NN
cord-000372-wzwpyvll	62	8	as	as	IN
cord-000372-wzwpyvll	62	9	a	a	DT
cord-000372-wzwpyvll	62	10	template	template	NN
cord-000372-wzwpyvll	62	11	to	to	TO
cord-000372-wzwpyvll	62	12	direct	direct	VB
cord-000372-wzwpyvll	62	13	the	the	DT
cord-000372-wzwpyvll	62	14	synthesis	synthesis	NN
cord-000372-wzwpyvll	62	15	of	of	IN
cord-000372-wzwpyvll	62	16	several	several	JJ
cord-000372-wzwpyvll	62	17	copies	copy	NNS
cord-000372-wzwpyvll	62	18	of	of	IN
cord-000372-wzwpyvll	62	19	positive	positive	JJ
cord-000372-wzwpyvll	62	20	RNA	RNA	NNP
cord-000372-wzwpyvll	62	21	,	,	,
cord-000372-wzwpyvll	62	22	so	so	RB
cord-000372-wzwpyvll	63	1	this	this	DT
cord-000372-wzwpyvll	63	2	process	process	NN
cord-000372-wzwpyvll	63	3	leads	lead	VBZ
cord-000372-wzwpyvll	63	4	to	to	IN
cord-000372-wzwpyvll	63	5	the	the	DT
cord-000372-wzwpyvll	63	6	production	production	NN
cord-000372-wzwpyvll	63	7	of	of	IN
cord-000372-wzwpyvll	63	8	several	several	JJ
cord-000372-wzwpyvll	63	9	nascent	nascent	JJ
cord-000372-wzwpyvll	63	10	RNA	RNA	NNP
cord-000372-wzwpyvll	63	11	molecules	molecule	NNS
cord-000372-wzwpyvll	63	12	with	with	IN
cord-000372-wzwpyvll	63	13	a	a	DT
cord-000372-wzwpyvll	63	14	VPg	vpg	NN
cord-000372-wzwpyvll	63	15	molecule	molecule	NN
cord-000372-wzwpyvll	63	16	bound	bind	VBN
cord-000372-wzwpyvll	63	17	to	to	IN
cord-000372-wzwpyvll	63	18	their	-PRON-	PRP$
cord-000372-wzwpyvll	63	19	5	5	CD
cord-000372-wzwpyvll	63	20	ends	end	NNS
cord-000372-wzwpyvll	63	21	on	on	IN
cord-000372-wzwpyvll	63	22	the	the	DT
cord-000372-wzwpyvll	63	23	negative	negative	JJ
cord-000372-wzwpyvll	63	24	RNA	RNA	NNP
cord-000372-wzwpyvll	63	25	molecule	molecule	NN
cord-000372-wzwpyvll	63	26	forming	form	VBG
cord-000372-wzwpyvll	63	27	a	a	DT
cord-000372-wzwpyvll	63	28	replicative	replicative	JJ
cord-000372-wzwpyvll	63	29	intermediate	intermediate	NN
cord-000372-wzwpyvll	63	30	.	.	.
cord-000372-wzwpyvll	64	1	The	the	DT
cord-000372-wzwpyvll	64	2	positive	positive	JJ
cord-000372-wzwpyvll	64	3	RNA	RNA	NNP
cord-000372-wzwpyvll	64	4	molecules	molecule	NNS
cord-000372-wzwpyvll	64	5	synthesized	synthesize	VBN
cord-000372-wzwpyvll	64	6	may	may	MD
cord-000372-wzwpyvll	64	7	participate	participate	VB
cord-000372-wzwpyvll	64	8	in	in	IN
cord-000372-wzwpyvll	64	9	three	three	CD
cord-000372-wzwpyvll	64	10	processes	process	NNS
cord-000372-wzwpyvll	64	11	(	(	-LRB-
cord-000372-wzwpyvll	64	12	i	i	NN
cord-000372-wzwpyvll	64	13	)	)	-RRB-
cord-000372-wzwpyvll	64	14	to	to	TO
cord-000372-wzwpyvll	64	15	serve	serve	VB
cord-000372-wzwpyvll	64	16	as	as	IN
cord-000372-wzwpyvll	64	17	templates	template	NNS
cord-000372-wzwpyvll	64	18	for	for	IN
cord-000372-wzwpyvll	64	19	synthesizing	synthesize	VBG
cord-000372-wzwpyvll	64	20	more	more	JJR
cord-000372-wzwpyvll	64	21	negative	negative	JJ
cord-000372-wzwpyvll	64	22	RNA	RNA	NNP
cord-000372-wzwpyvll	64	23	molecules	molecule	NNS
cord-000372-wzwpyvll	64	24	;	;	,
cord-000372-wzwpyvll	64	25	(	(	-LRB-
cord-000372-wzwpyvll	64	26	ii	ii	NN
cord-000372-wzwpyvll	64	27	)	)	-RRB-
cord-000372-wzwpyvll	64	28	as	as	IN
cord-000372-wzwpyvll	64	29	mRNAs	mRNAs	NNPS
cord-000372-wzwpyvll	64	30	that	that	WDT
cord-000372-wzwpyvll	64	31	will	will	MD
cord-000372-wzwpyvll	64	32	be	be	VB
cord-000372-wzwpyvll	64	33	engaged	engage	VBN
cord-000372-wzwpyvll	64	34	in	in	IN
cord-000372-wzwpyvll	64	35	translation	translation	NN
cord-000372-wzwpyvll	64	36	,	,	,
cord-000372-wzwpyvll	64	37	and	and	CC
cord-000372-wzwpyvll	64	38	(	(	-LRB-
cord-000372-wzwpyvll	64	39	iii	iii	NN
cord-000372-wzwpyvll	64	40	)	)	-RRB-
cord-000372-wzwpyvll	64	41	as	as	IN
cord-000372-wzwpyvll	64	42	genomes	genome	NNS
cord-000372-wzwpyvll	64	43	that	that	WDT
cord-000372-wzwpyvll	64	44	will	will	MD
cord-000372-wzwpyvll	64	45	be	be	VB
cord-000372-wzwpyvll	64	46	encapsidated	encapsidate	VBN
cord-000372-wzwpyvll	64	47	in	in	IN
cord-000372-wzwpyvll	64	48	new	new	JJ
cord-000372-wzwpyvll	64	49	viral	viral	JJ
cord-000372-wzwpyvll	64	50	particles	particle	NNS
cord-000372-wzwpyvll	64	51	.	.	.
cord-000372-wzwpyvll	65	1	In	in	IN
cord-000372-wzwpyvll	65	2	picornaviruses	picornavirus	NNS
cord-000372-wzwpyvll	65	3	,	,	,
cord-000372-wzwpyvll	65	4	the	the	DT
cord-000372-wzwpyvll	65	5	only	only	JJ
cord-000372-wzwpyvll	65	6	type	type	NN
cord-000372-wzwpyvll	65	7	of	of	IN
cord-000372-wzwpyvll	65	8	mRNA	mrna	NN
cord-000372-wzwpyvll	65	9	molecule	molecule	NN
cord-000372-wzwpyvll	65	10	known	know	VBN
cord-000372-wzwpyvll	65	11	is	be	VBZ
cord-000372-wzwpyvll	65	12	exactly	exactly	RB
cord-000372-wzwpyvll	65	13	the	the	DT
cord-000372-wzwpyvll	65	14	same	same	JJ
cord-000372-wzwpyvll	65	15	as	as	IN
cord-000372-wzwpyvll	65	16	the	the	DT
cord-000372-wzwpyvll	65	17	genome	genome	NN
cord-000372-wzwpyvll	65	18	.	.	.
cord-000372-wzwpyvll	66	1	Once	once	IN
cord-000372-wzwpyvll	66	2	the	the	DT
cord-000372-wzwpyvll	66	3	synthesis	synthesis	NN
cord-000372-wzwpyvll	66	4	of	of	IN
cord-000372-wzwpyvll	66	5	several	several	JJ
cord-000372-wzwpyvll	66	6	thousands	thousand	NNS
cord-000372-wzwpyvll	66	7	of	of	IN
cord-000372-wzwpyvll	66	8	positive	positive	JJ
cord-000372-wzwpyvll	66	9	RNA	RNA	NNP
cord-000372-wzwpyvll	66	10	molecules	molecule	NNS
cord-000372-wzwpyvll	66	11	is	be	VBZ
cord-000372-wzwpyvll	66	12	performed	perform	VBN
cord-000372-wzwpyvll	66	13	,	,	,
cord-000372-wzwpyvll	66	14	the	the	DT
cord-000372-wzwpyvll	66	15	late	late	JJ
cord-000372-wzwpyvll	66	16	phase	phase	NN
cord-000372-wzwpyvll	66	17	of	of	IN
cord-000372-wzwpyvll	66	18	translation	translation	NN
cord-000372-wzwpyvll	66	19	takes	take	VBZ
cord-000372-wzwpyvll	66	20	place	place	NN
cord-000372-wzwpyvll	66	21	,	,	,
cord-000372-wzwpyvll	66	22	giving	give	VBG
cord-000372-wzwpyvll	66	23	rise	rise	NN
cord-000372-wzwpyvll	66	24	also	also	RB
cord-000372-wzwpyvll	66	25	during	during	IN
cord-000372-wzwpyvll	66	26	this	this	DT
cord-000372-wzwpyvll	66	27	period	period	NN
cord-000372-wzwpyvll	66	28	to	to	IN
cord-000372-wzwpyvll	66	29	a	a	DT
cord-000372-wzwpyvll	66	30	great	great	JJ
cord-000372-wzwpyvll	66	31	amount	amount	NN
cord-000372-wzwpyvll	66	32	of	of	IN
cord-000372-wzwpyvll	66	33	viral	viral	JJ
cord-000372-wzwpyvll	66	34	proteins	protein	NNS
cord-000372-wzwpyvll	66	35	,	,	,
cord-000372-wzwpyvll	66	36	some	some	DT
cord-000372-wzwpyvll	66	37	of	of	IN
cord-000372-wzwpyvll	66	38	which	which	WDT
cord-000372-wzwpyvll	66	39	will	will	MD
cord-000372-wzwpyvll	66	40	participate	participate	VB
cord-000372-wzwpyvll	66	41	in	in	IN
cord-000372-wzwpyvll	66	42	virus	virus	NN
cord-000372-wzwpyvll	66	43	morphogenesis	morphogenesis	NN
cord-000372-wzwpyvll	66	44	.	.	.
cord-000372-wzwpyvll	67	1	This	this	DT
cord-000372-wzwpyvll	67	2	late	late	JJ
cord-000372-wzwpyvll	67	3	phase	phase	NN
cord-000372-wzwpyvll	67	4	of	of	IN
cord-000372-wzwpyvll	67	5	infection	infection	NN
cord-000372-wzwpyvll	67	6	is	be	VBZ
cord-000372-wzwpyvll	67	7	preceded	precede	VBN
cord-000372-wzwpyvll	67	8	by	by	IN
cord-000372-wzwpyvll	67	9	the	the	DT
cord-000372-wzwpyvll	67	10	abrogation	abrogation	NN
cord-000372-wzwpyvll	67	11	of	of	IN
cord-000372-wzwpyvll	67	12	cellular	cellular	JJ
cord-000372-wzwpyvll	67	13	mRNA	mrna	NN
cord-000372-wzwpyvll	67	14	translation	translation	NN
cord-000372-wzwpyvll	67	15	,	,	,
cord-000372-wzwpyvll	67	16	such	such	JJ
cord-000372-wzwpyvll	67	17	that	that	IN
cord-000372-wzwpyvll	67	18	only	only	JJ
cord-000372-wzwpyvll	67	19	viral	viral	JJ
cord-000372-wzwpyvll	67	20	proteins	protein	NNS
cord-000372-wzwpyvll	67	21	are	be	VBP
cord-000372-wzwpyvll	67	22	being	be	VBG
cord-000372-wzwpyvll	67	23	synthesized	synthesize	VBN
cord-000372-wzwpyvll	67	24	late	late	RB
cord-000372-wzwpyvll	67	25	in	in	IN
cord-000372-wzwpyvll	67	26	the	the	DT
cord-000372-wzwpyvll	67	27	PV	PV	NNP
cord-000372-wzwpyvll	67	28	life	life	NN
cord-000372-wzwpyvll	67	29	cycle	cycle	NN
cord-000372-wzwpyvll	67	30	[	[	-LRB-
cord-000372-wzwpyvll	67	31	14	14	CD
cord-000372-wzwpyvll	67	32	]	]	-RRB-
cord-000372-wzwpyvll	67	33	.	.	.
cord-000372-wzwpyvll	68	1	In	in	IN
cord-000372-wzwpyvll	68	2	the	the	DT
cord-000372-wzwpyvll	68	3	case	case	NN
cord-000372-wzwpyvll	68	4	of	of	IN
cord-000372-wzwpyvll	68	5	picornaviruses	picornavirus	NNS
cord-000372-wzwpyvll	68	6	,	,	,
cord-000372-wzwpyvll	68	7	transcription	transcription	NN
cord-000372-wzwpyvll	68	8	is	be	VBZ
cord-000372-wzwpyvll	68	9	dependent	dependent	JJ
cord-000372-wzwpyvll	68	10	on	on	IN
cord-000372-wzwpyvll	68	11	continuous	continuous	JJ
cord-000372-wzwpyvll	68	12	viral	viral	JJ
cord-000372-wzwpyvll	68	13	protein	protein	NN
cord-000372-wzwpyvll	68	14	synthesis	synthesis	NN
cord-000372-wzwpyvll	68	15	[	[	-LRB-
cord-000372-wzwpyvll	68	16	28	28	CD
cord-000372-wzwpyvll	68	17	]	]	-RRB-
cord-000372-wzwpyvll	68	18	.	.	.
cord-000372-wzwpyvll	69	1	Thus	thus	RB
cord-000372-wzwpyvll	69	2	,	,	,
cord-000372-wzwpyvll	69	3	inhibition	inhibition	NN
cord-000372-wzwpyvll	69	4	of	of	IN
cord-000372-wzwpyvll	69	5	viral	viral	JJ
cord-000372-wzwpyvll	69	6	mRNA	mRNA	NNP
cord-000372-wzwpyvll	69	7	translation	translation	NN
cord-000372-wzwpyvll	69	8	provokes	provoke	VBZ
cord-000372-wzwpyvll	69	9	the	the	DT
cord-000372-wzwpyvll	69	10	sudden	sudden	JJ
cord-000372-wzwpyvll	69	11	blockade	blockade	NN
cord-000372-wzwpyvll	69	12	of	of	IN
cord-000372-wzwpyvll	69	13	viral	viral	JJ
cord-000372-wzwpyvll	69	14	RNA	RNA	NNP
cord-000372-wzwpyvll	69	15	synthesis	synthesis	NN
cord-000372-wzwpyvll	69	16	.	.	.
cord-000372-wzwpyvll	70	1	Moreover	moreover	RB
cord-000372-wzwpyvll	70	2	,	,	,
cord-000372-wzwpyvll	70	3	translation	translation	NN
cord-000372-wzwpyvll	70	4	is	be	VBZ
cord-000372-wzwpyvll	70	5	coupled	couple	VBN
cord-000372-wzwpyvll	70	6	to	to	IN
cord-000372-wzwpyvll	70	7	transcription	transcription	NN
cord-000372-wzwpyvll	70	8	,	,	,
cord-000372-wzwpyvll	70	9	such	such	JJ
cord-000372-wzwpyvll	70	10	that	that	IN
cord-000372-wzwpyvll	70	11	viral	viral	JJ
cord-000372-wzwpyvll	70	12	RNAs	rna	NNS
cord-000372-wzwpyvll	70	13	transfected	transfecte	VBD
cord-000372-wzwpyvll	70	14	Journal	Journal	NNP
cord-000372-wzwpyvll	70	15	of	of	IN
cord-000372-wzwpyvll	70	16	Biomedicine	Biomedicine	NNP
cord-000372-wzwpyvll	70	17	and	and	CC
cord-000372-wzwpyvll	70	18	Biotechnology	Biotechnology	NNP
cord-000372-wzwpyvll	70	19	Figure	Figure	NNP
cord-000372-wzwpyvll	70	20	1	1	CD
cord-000372-wzwpyvll	70	21	:	:	:
cord-000372-wzwpyvll	70	22	(	(	-LRB-
cord-000372-wzwpyvll	70	23	a	a	LS
cord-000372-wzwpyvll	70	24	)	)	-RRB-
cord-000372-wzwpyvll	70	25	Structure	structure	NN
cord-000372-wzwpyvll	70	26	of	of	IN
cord-000372-wzwpyvll	70	27	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	70	28	genome	genome	NN
cord-000372-wzwpyvll	70	29	and	and	CC
cord-000372-wzwpyvll	70	30	proteolytic	proteolytic	JJ
cord-000372-wzwpyvll	70	31	processing	processing	NN
cord-000372-wzwpyvll	70	32	of	of	IN
cord-000372-wzwpyvll	70	33	its	-PRON-	PRP$
cord-000372-wzwpyvll	70	34	polyprotein	polyprotein	NN
cord-000372-wzwpyvll	70	35	.	.	.
cord-000372-wzwpyvll	71	1	The	the	DT
cord-000372-wzwpyvll	71	2	PV	PV	NNP
cord-000372-wzwpyvll	71	3	genome	genome	NN
cord-000372-wzwpyvll	71	4	consists	consist	VBZ
cord-000372-wzwpyvll	71	5	of	of	IN
cord-000372-wzwpyvll	71	6	a	a	DT
cord-000372-wzwpyvll	71	7	single	single	RB
cord-000372-wzwpyvll	71	8	-	-	HYPH
cord-000372-wzwpyvll	71	9	stranded	stranded	JJ
cord-000372-wzwpyvll	71	10	,	,	,
cord-000372-wzwpyvll	71	11	positive	positive	JJ
cord-000372-wzwpyvll	71	12	-	-	HYPH
cord-000372-wzwpyvll	71	13	sense	sense	NN
cord-000372-wzwpyvll	71	14	polarity	polarity	NN
cord-000372-wzwpyvll	71	15	RNA	rna	NN
cord-000372-wzwpyvll	71	16	molecule	molecule	NN
cord-000372-wzwpyvll	71	17	,	,	,
cord-000372-wzwpyvll	71	18	which	which	WDT
cord-000372-wzwpyvll	71	19	encodes	encode	VBZ
cord-000372-wzwpyvll	71	20	a	a	DT
cord-000372-wzwpyvll	71	21	single	single	JJ
cord-000372-wzwpyvll	71	22	polyprotein	polyprotein	NN
cord-000372-wzwpyvll	71	23	.	.	.
cord-000372-wzwpyvll	72	1	The	the	DT
cord-000372-wzwpyvll	72	2	5	5	CD
cord-000372-wzwpyvll	72	3	nontranslated	nontranslated	JJ
cord-000372-wzwpyvll	72	4	region	region	NN
cord-000372-wzwpyvll	72	5	(	(	-LRB-
cord-000372-wzwpyvll	72	6	NTR	NTR	NNP
cord-000372-wzwpyvll	72	7	)	)	-RRB-
cord-000372-wzwpyvll	72	8	is	be	VBZ
cord-000372-wzwpyvll	72	9	covalently	covalently	RB
cord-000372-wzwpyvll	72	10	linked	link	VBN
cord-000372-wzwpyvll	72	11	to	to	IN
cord-000372-wzwpyvll	72	12	the	the	DT
cord-000372-wzwpyvll	72	13	viral	viral	JJ
cord-000372-wzwpyvll	72	14	protein	protein	NN
cord-000372-wzwpyvll	72	15	VPg	VPg	NNS
cord-000372-wzwpyvll	72	16	.	.	.
cord-000372-wzwpyvll	73	1	The	the	DT
cord-000372-wzwpyvll	73	2	PV	PV	NNP
cord-000372-wzwpyvll	73	3	genome	genome	NN
cord-000372-wzwpyvll	73	4	is	be	VBZ
cord-000372-wzwpyvll	73	5	polyadenylated	polyadenylate	VBN
cord-000372-wzwpyvll	73	6	(	(	-LRB-
cord-000372-wzwpyvll	73	7	A	a	DT
cord-000372-wzwpyvll	73	8	n	n	NN
cord-000372-wzwpyvll	73	9	)	)	-RRB-
cord-000372-wzwpyvll	73	10	in	in	IN
cord-000372-wzwpyvll	73	11	its	-PRON-	PRP$
cord-000372-wzwpyvll	73	12	3	3	CD
cord-000372-wzwpyvll	73	13	end	end	NN
cord-000372-wzwpyvll	73	14	.	.	.
cord-000372-wzwpyvll	74	1	The	the	DT
cord-000372-wzwpyvll	74	2	polyprotein	polyprotein	NN
cord-000372-wzwpyvll	74	3	contains	contain	VBZ
cord-000372-wzwpyvll	74	4	four	four	CD
cord-000372-wzwpyvll	74	5	structural	structural	JJ
cord-000372-wzwpyvll	74	6	(	(	-LRB-
cord-000372-wzwpyvll	74	7	P1	P1	NNP
cord-000372-wzwpyvll	74	8	)	)	-RRB-
cord-000372-wzwpyvll	74	9	and	and	CC
cord-000372-wzwpyvll	74	10	seven	seven	CD
cord-000372-wzwpyvll	74	11	nonstructural	nonstructural	JJ
cord-000372-wzwpyvll	74	12	(	(	-LRB-
cord-000372-wzwpyvll	74	13	P2	P2	NNP
cord-000372-wzwpyvll	74	14	and	and	CC
cord-000372-wzwpyvll	74	15	P3	P3	NNP
cord-000372-wzwpyvll	74	16	)	)	-RRB-
cord-000372-wzwpyvll	74	17	proteins	protein	NNS
cord-000372-wzwpyvll	74	18	that	that	WDT
cord-000372-wzwpyvll	74	19	are	be	VBP
cord-000372-wzwpyvll	74	20	released	release	VBN
cord-000372-wzwpyvll	74	21	from	from	IN
cord-000372-wzwpyvll	74	22	the	the	DT
cord-000372-wzwpyvll	74	23	polypeptide	polypeptide	NN
cord-000372-wzwpyvll	74	24	chain	chain	NN
cord-000372-wzwpyvll	74	25	by	by	IN
cord-000372-wzwpyvll	74	26	proteolytic	proteolytic	JJ
cord-000372-wzwpyvll	74	27	processing	processing	NN
cord-000372-wzwpyvll	74	28	mediated	mediate	VBN
cord-000372-wzwpyvll	74	29	by	by	IN
cord-000372-wzwpyvll	74	30	the	the	DT
cord-000372-wzwpyvll	74	31	viral	viral	RB
cord-000372-wzwpyvll	74	32	-	-	HYPH
cord-000372-wzwpyvll	74	33	encoded	encode	VBN
cord-000372-wzwpyvll	74	34	proteinases	proteinases	NNP
cord-000372-wzwpyvll	74	35	2A	2A	NNP
cord-000372-wzwpyvll	74	36	pro	pro	NNP
cord-000372-wzwpyvll	74	37	and	and	CC
cord-000372-wzwpyvll	74	38	3C	3C	NNP
cord-000372-wzwpyvll	74	39	pro	pro	NNP
cord-000372-wzwpyvll	74	40	/3CD	/3CD	.
cord-000372-wzwpyvll	74	41	pro	pro	JJ
cord-000372-wzwpyvll	74	42	.	.	.
cord-000372-wzwpyvll	75	1	The	the	DT
cord-000372-wzwpyvll	75	2	intermediate	intermediate	JJ
cord-000372-wzwpyvll	75	3	products	product	NNS
cord-000372-wzwpyvll	75	4	of	of	IN
cord-000372-wzwpyvll	75	5	processing	process	VBG
cord-000372-wzwpyvll	75	6	2BC	2BC	NNP
cord-000372-wzwpyvll	75	7	,	,	,
cord-000372-wzwpyvll	75	8	3CD	3CD	NNP
cord-000372-wzwpyvll	75	9	,	,	,
cord-000372-wzwpyvll	75	10	and	and	CC
cord-000372-wzwpyvll	75	11	3AB	3ab	CD
cord-000372-wzwpyvll	75	12	exhibit	exhibit	NN
cord-000372-wzwpyvll	75	13	functions	function	NNS
cord-000372-wzwpyvll	75	14	distinct	distinct	JJ
cord-000372-wzwpyvll	75	15	from	from	IN
cord-000372-wzwpyvll	75	16	those	those	DT
cord-000372-wzwpyvll	75	17	of	of	IN
cord-000372-wzwpyvll	75	18	their	-PRON-	PRP$
cord-000372-wzwpyvll	75	19	respective	respective	JJ
cord-000372-wzwpyvll	75	20	final	final	JJ
cord-000372-wzwpyvll	75	21	cleavage	cleavage	NN
cord-000372-wzwpyvll	75	22	products	product	NNS
cord-000372-wzwpyvll	75	23	.	.	.
cord-000372-wzwpyvll	76	1	The	the	DT
cord-000372-wzwpyvll	76	2	alternative	alternative	JJ
cord-000372-wzwpyvll	76	3	cleavage	cleavage	NN
cord-000372-wzwpyvll	76	4	carried	carry	VBN
cord-000372-wzwpyvll	76	5	out	out	RP
cord-000372-wzwpyvll	76	6	by	by	IN
cord-000372-wzwpyvll	76	7	2A	2a	CD
cord-000372-wzwpyvll	76	8	pro	pro	JJ
cord-000372-wzwpyvll	76	9	rendering	render	VBG
cord-000372-wzwpyvll	76	10	the	the	DT
cord-000372-wzwpyvll	76	11	mature	mature	JJ
cord-000372-wzwpyvll	76	12	products	product	NNS
cord-000372-wzwpyvll	76	13	3C	3C	NNP
cord-000372-wzwpyvll	76	14	and	and	CC
cord-000372-wzwpyvll	76	15	3D	3D	NNP
cord-000372-wzwpyvll	76	16	is	be	VBZ
cord-000372-wzwpyvll	76	17	also	also	RB
cord-000372-wzwpyvll	76	18	shown	show	VBN
cord-000372-wzwpyvll	76	19	.	.	.
cord-000372-wzwpyvll	77	1	(	(	-LRB-
cord-000372-wzwpyvll	77	2	b	b	LS
cord-000372-wzwpyvll	77	3	)	)	-RRB-
cord-000372-wzwpyvll	77	4	Once	once	IN
cord-000372-wzwpyvll	77	5	the	the	DT
cord-000372-wzwpyvll	77	6	ribosome	ribosome	NN
cord-000372-wzwpyvll	77	7	has	have	VBZ
cord-000372-wzwpyvll	77	8	synthesized	synthesize	VBN
cord-000372-wzwpyvll	77	9	the	the	DT
cord-000372-wzwpyvll	77	10	PV	PV	NNP
cord-000372-wzwpyvll	77	11	2A	2a	NN
cord-000372-wzwpyvll	77	12	pro	pro	JJ
cord-000372-wzwpyvll	77	13	sequence	sequence	NN
cord-000372-wzwpyvll	77	14	and	and	CC
cord-000372-wzwpyvll	77	15	continues	continue	VBZ
cord-000372-wzwpyvll	77	16	translation	translation	NN
cord-000372-wzwpyvll	77	17	on	on	IN
cord-000372-wzwpyvll	77	18	the	the	DT
cord-000372-wzwpyvll	77	19	P2	P2	NNP
cord-000372-wzwpyvll	77	20	region	region	NN
cord-000372-wzwpyvll	77	21	,	,	,
cord-000372-wzwpyvll	77	22	the	the	DT
cord-000372-wzwpyvll	77	23	autocatalytic	autocatalytic	JJ
cord-000372-wzwpyvll	77	24	activity	activity	NN
cord-000372-wzwpyvll	77	25	of	of	IN
cord-000372-wzwpyvll	77	26	PV	PV	NNP
cord-000372-wzwpyvll	77	27	2A	2a	CD
cord-000372-wzwpyvll	77	28	pro	pro	NNP
cord-000372-wzwpyvll	77	29	is	be	VBZ
cord-000372-wzwpyvll	77	30	manifested	manifest	VBN
cord-000372-wzwpyvll	77	31	by	by	IN
cord-000372-wzwpyvll	77	32	cleaving	cleave	VBG
cord-000372-wzwpyvll	77	33	itself	-PRON-	PRP
cord-000372-wzwpyvll	77	34	at	at	IN
cord-000372-wzwpyvll	77	35	its	-PRON-	PRP$
cord-000372-wzwpyvll	77	36	amino	amino	NN
cord-000372-wzwpyvll	77	37	terminus	terminus	NN
cord-000372-wzwpyvll	77	38	still	still	RB
cord-000372-wzwpyvll	77	39	on	on	IN
cord-000372-wzwpyvll	77	40	the	the	DT
cord-000372-wzwpyvll	77	41	nascent	nascent	JJ
cord-000372-wzwpyvll	77	42	polypeptide	polypeptide	NN
cord-000372-wzwpyvll	77	43	chain	chain	NN
cord-000372-wzwpyvll	77	44	.	.	.
cord-000372-wzwpyvll	78	1	This	this	DT
cord-000372-wzwpyvll	78	2	cleavage	cleavage	NN
cord-000372-wzwpyvll	78	3	liberates	liberate	VBZ
cord-000372-wzwpyvll	78	4	the	the	DT
cord-000372-wzwpyvll	78	5	P1	P1	NNP
cord-000372-wzwpyvll	78	6	precursor	precursor	NN
cord-000372-wzwpyvll	78	7	that	that	WDT
cord-000372-wzwpyvll	78	8	will	will	MD
cord-000372-wzwpyvll	78	9	render	render	VB
cord-000372-wzwpyvll	78	10	the	the	DT
cord-000372-wzwpyvll	78	11	capsid	capsid	NN
cord-000372-wzwpyvll	78	12	proteins	protein	NNS
cord-000372-wzwpyvll	78	13	on	on	IN
cord-000372-wzwpyvll	78	14	subsequent	subsequent	JJ
cord-000372-wzwpyvll	78	15	proteolytic	proteolytic	JJ
cord-000372-wzwpyvll	78	16	events	event	NNS
cord-000372-wzwpyvll	78	17	catalyzed	catalyze	VBN
cord-000372-wzwpyvll	78	18	by	by	IN
cord-000372-wzwpyvll	78	19	3C	3C	NNP
cord-000372-wzwpyvll	78	20	pro	pro	NNP
cord-000372-wzwpyvll	78	21	or	or	CC
cord-000372-wzwpyvll	78	22	3CD	3CD	NNP
cord-000372-wzwpyvll	78	23	pro	pro	NN
cord-000372-wzwpyvll	78	24	.	.	.
cord-000372-wzwpyvll	79	1	Cleavage	cleavage	NN
cord-000372-wzwpyvll	79	2	at	at	IN
cord-000372-wzwpyvll	79	3	the	the	DT
cord-000372-wzwpyvll	79	4	carboxy	carboxy	JJ
cord-000372-wzwpyvll	79	5	terminus	terminus	NN
cord-000372-wzwpyvll	79	6	of	of	IN
cord-000372-wzwpyvll	79	7	PV	PV	NNP
cord-000372-wzwpyvll	79	8	2A	2a	CD
cord-000372-wzwpyvll	79	9	pro	pro	JJ
cord-000372-wzwpyvll	79	10	on	on	IN
cord-000372-wzwpyvll	79	11	the	the	DT
cord-000372-wzwpyvll	79	12	P2	P2	NNP
cord-000372-wzwpyvll	79	13	precursor	precursor	NN
cord-000372-wzwpyvll	79	14	is	be	VBZ
cord-000372-wzwpyvll	79	15	accomplished	accomplish	VBN
cord-000372-wzwpyvll	79	16	by	by	IN
cord-000372-wzwpyvll	79	17	PV	PV	NNP
cord-000372-wzwpyvll	79	18	3C	3C	NNP
cord-000372-wzwpyvll	79	19	pro	pro	NNP
cord-000372-wzwpyvll	79	20	,	,	,
cord-000372-wzwpyvll	79	21	leaving	leave	VBG
cord-000372-wzwpyvll	79	22	free	free	JJ
cord-000372-wzwpyvll	79	23	2A	2a	CD
cord-000372-wzwpyvll	79	24	pro	pro	JJ
cord-000372-wzwpyvll	79	25	and	and	CC
cord-000372-wzwpyvll	79	26	generating	generate	VBG
cord-000372-wzwpyvll	79	27	the	the	DT
cord-000372-wzwpyvll	79	28	2BC	2bc	NN
cord-000372-wzwpyvll	79	29	precursor	precursor	NN
cord-000372-wzwpyvll	79	30	.	.	.
cord-000372-wzwpyvll	80	1	into	into	IN
cord-000372-wzwpyvll	80	2	picornavirus	picornavirus	NNP
cord-000372-wzwpyvll	80	3	-	-	HYPH
cord-000372-wzwpyvll	80	4	infected	infect	VBN
cord-000372-wzwpyvll	80	5	cells	cell	NNS
cord-000372-wzwpyvll	80	6	are	be	VBP
cord-000372-wzwpyvll	80	7	not	not	RB
cord-000372-wzwpyvll	80	8	able	able	JJ
cord-000372-wzwpyvll	80	9	to	to	TO
cord-000372-wzwpyvll	80	10	direct	direct	VB
cord-000372-wzwpyvll	80	11	protein	protein	NN
cord-000372-wzwpyvll	80	12	synthesis	synthesis	NN
cord-000372-wzwpyvll	80	13	[	[	-LRB-
cord-000372-wzwpyvll	80	14	29	29	CD
cord-000372-wzwpyvll	80	15	]	]	-RRB-
cord-000372-wzwpyvll	80	16	.	.	.
cord-000372-wzwpyvll	81	1	Therefore	therefore	RB
cord-000372-wzwpyvll	81	2	,	,	,
cord-000372-wzwpyvll	81	3	these	these	DT
cord-000372-wzwpyvll	81	4	two	two	CD
cord-000372-wzwpyvll	81	5	processes	process	NNS
cord-000372-wzwpyvll	81	6	of	of	IN
cord-000372-wzwpyvll	81	7	viral	viral	JJ
cord-000372-wzwpyvll	81	8	macromolecular	macromolecular	JJ
cord-000372-wzwpyvll	81	9	biosynthesis	biosynthesis	NN
cord-000372-wzwpyvll	81	10	are	be	VBP
cord-000372-wzwpyvll	81	11	tightly	tightly	RB
cord-000372-wzwpyvll	81	12	coupled	couple	VBN
cord-000372-wzwpyvll	81	13	,	,	,
cord-000372-wzwpyvll	81	14	making	make	VBG
cord-000372-wzwpyvll	81	15	it	-PRON-	PRP
cord-000372-wzwpyvll	81	16	difficult	difficult	JJ
cord-000372-wzwpyvll	81	17	to	to	TO
cord-000372-wzwpyvll	81	18	determine	determine	VB
cord-000372-wzwpyvll	81	19	exactly	exactly	RB
cord-000372-wzwpyvll	81	20	the	the	DT
cord-000372-wzwpyvll	81	21	function	function	NN
cord-000372-wzwpyvll	81	22	affected	affect	VBN
cord-000372-wzwpyvll	81	23	in	in	IN
cord-000372-wzwpyvll	81	24	some	some	DT
cord-000372-wzwpyvll	81	25	PV	pv	NN
cord-000372-wzwpyvll	81	26	mutants	mutant	NNS
cord-000372-wzwpyvll	81	27	.	.	.
cord-000372-wzwpyvll	82	1	Notably	notably	RB
cord-000372-wzwpyvll	82	2	,	,	,
cord-000372-wzwpyvll	82	3	continuous	continuous	JJ
cord-000372-wzwpyvll	82	4	lipid	lipid	NN
cord-000372-wzwpyvll	82	5	and	and	CC
cord-000372-wzwpyvll	82	6	cellular	cellular	JJ
cord-000372-wzwpyvll	82	7	membrane	membrane	NN
cord-000372-wzwpyvll	82	8	synthesis	synthesis	NN
cord-000372-wzwpyvll	82	9	is	be	VBZ
cord-000372-wzwpyvll	82	10	also	also	RB
cord-000372-wzwpyvll	82	11	necessary	necessary	JJ
cord-000372-wzwpyvll	82	12	for	for	IN
cord-000372-wzwpyvll	82	13	PV	PV	NNP
cord-000372-wzwpyvll	82	14	RNA	RNA	NNP
cord-000372-wzwpyvll	82	15	synthesis	synthesis	NN
cord-000372-wzwpyvll	82	16	[	[	-LRB-
cord-000372-wzwpyvll	82	17	30	30	CD
cord-000372-wzwpyvll	82	18	]	]	-RRB-
cord-000372-wzwpyvll	82	19	.	.	.
cord-000372-wzwpyvll	83	1	The	the	DT
cord-000372-wzwpyvll	83	2	morphogenesis	morphogenesis	NN
cord-000372-wzwpyvll	83	3	of	of	IN
cord-000372-wzwpyvll	83	4	progeny	progeny	JJ
cord-000372-wzwpyvll	83	5	virions	virion	NNS
cord-000372-wzwpyvll	83	6	in	in	IN
cord-000372-wzwpyvll	83	7	PV	pv	NN
cord-000372-wzwpyvll	83	8	-	-	HYPH
cord-000372-wzwpyvll	83	9	infected	infect	VBN
cord-000372-wzwpyvll	83	10	cells	cell	NNS
cord-000372-wzwpyvll	83	11	is	be	VBZ
cord-000372-wzwpyvll	83	12	observed	observe	VBN
cord-000372-wzwpyvll	83	13	concomitantly	concomitantly	RB
cord-000372-wzwpyvll	83	14	with	with	IN
cord-000372-wzwpyvll	83	15	viral	viral	JJ
cord-000372-wzwpyvll	83	16	RNA	RNA	NNP
cord-000372-wzwpyvll	83	17	translation	translation	NN
cord-000372-wzwpyvll	83	18	and	and	CC
cord-000372-wzwpyvll	83	19	replication	replication	NN
cord-000372-wzwpyvll	83	20	.	.	.
cord-000372-wzwpyvll	84	1	The	the	DT
cord-000372-wzwpyvll	84	2	release	release	NN
cord-000372-wzwpyvll	84	3	of	of	IN
cord-000372-wzwpyvll	84	4	new	new	JJ
cord-000372-wzwpyvll	84	5	viral	viral	JJ
cord-000372-wzwpyvll	84	6	particles	particle	NNS
cord-000372-wzwpyvll	84	7	takes	take	VBZ
cord-000372-wzwpyvll	84	8	place	place	NN
cord-000372-wzwpyvll	84	9	by	by	IN
cord-000372-wzwpyvll	84	10	cell	cell	NN
cord-000372-wzwpyvll	84	11	lysis	lysis	NN
cord-000372-wzwpyvll	84	12	,	,	,
cord-000372-wzwpyvll	84	13	due	due	IN
cord-000372-wzwpyvll	84	14	to	to	IN
cord-000372-wzwpyvll	84	15	membrane	membrane	NN
cord-000372-wzwpyvll	84	16	permeabilization	permeabilization	NN
cord-000372-wzwpyvll	84	17	that	that	WDT
cord-000372-wzwpyvll	84	18	occurs	occur	VBZ
cord-000372-wzwpyvll	84	19	at	at	IN
cord-000372-wzwpyvll	84	20	the	the	DT
cord-000372-wzwpyvll	84	21	late	late	JJ
cord-000372-wzwpyvll	84	22	phase	phase	NN
cord-000372-wzwpyvll	84	23	of	of	IN
cord-000372-wzwpyvll	84	24	infection	infection	NN
cord-000372-wzwpyvll	84	25	[	[	-LRB-
cord-000372-wzwpyvll	84	26	31	31	CD
cord-000372-wzwpyvll	84	27	]	]	-RRB-
cord-000372-wzwpyvll	84	28	.	.	.
cord-000372-wzwpyvll	85	1	Viroporin	Viroporin	NNP
cord-000372-wzwpyvll	85	2	2B	2b	CD
cord-000372-wzwpyvll	85	3	and	and	CC
cord-000372-wzwpyvll	85	4	its	-PRON-	PRP$
cord-000372-wzwpyvll	85	5	precursor	precursor	NN
cord-000372-wzwpyvll	85	6	2BC	2BC	NNP
cord-000372-wzwpyvll	85	7	are	be	VBP
cord-000372-wzwpyvll	85	8	responsible	responsible	JJ
cord-000372-wzwpyvll	85	9	for	for	IN
cord-000372-wzwpyvll	85	10	this	this	DT
cord-000372-wzwpyvll	85	11	permeabilization	permeabilization	NN
cord-000372-wzwpyvll	85	12	upon	upon	IN
cord-000372-wzwpyvll	85	13	the	the	DT
cord-000372-wzwpyvll	85	14	formation	formation	NN
cord-000372-wzwpyvll	85	15	of	of	IN
cord-000372-wzwpyvll	85	16	pore	pore	NN
cord-000372-wzwpyvll	85	17	channels	channel	NNS
cord-000372-wzwpyvll	85	18	in	in	IN
cord-000372-wzwpyvll	85	19	cellular	cellular	JJ
cord-000372-wzwpyvll	85	20	membranes	membrane	NNS
cord-000372-wzwpyvll	85	21	[	[	-LRB-
cord-000372-wzwpyvll	85	22	32	32	CD
cord-000372-wzwpyvll	85	23	,	,	,
cord-000372-wzwpyvll	85	24	33	33	CD
cord-000372-wzwpyvll	85	25	]	]	-RRB-
cord-000372-wzwpyvll	85	26	.	.	.
cord-000372-wzwpyvll	86	1	PV	PV	NNP
cord-000372-wzwpyvll	86	2	has	have	VBZ
cord-000372-wzwpyvll	86	3	represented	represent	VBN
cord-000372-wzwpyvll	86	4	a	a	DT
cord-000372-wzwpyvll	86	5	useful	useful	JJ
cord-000372-wzwpyvll	86	6	model	model	NN
cord-000372-wzwpyvll	86	7	to	to	TO
cord-000372-wzwpyvll	86	8	gain	gain	VB
cord-000372-wzwpyvll	86	9	insight	insight	NN
cord-000372-wzwpyvll	86	10	into	into	IN
cord-000372-wzwpyvll	86	11	diverse	diverse	JJ
cord-000372-wzwpyvll	86	12	aspects	aspect	NNS
cord-000372-wzwpyvll	86	13	of	of	IN
cord-000372-wzwpyvll	86	14	molecular	molecular	JJ
cord-000372-wzwpyvll	86	15	biology	biology	NN
cord-000372-wzwpyvll	86	16	and	and	CC
cord-000372-wzwpyvll	86	17	gene	gene	NN
cord-000372-wzwpyvll	86	18	expression	expression	NN
cord-000372-wzwpyvll	86	19	.	.	.
cord-000372-wzwpyvll	87	1	A	a	DT
cord-000372-wzwpyvll	87	2	number	number	NN
cord-000372-wzwpyvll	87	3	of	of	IN
cord-000372-wzwpyvll	87	4	discoveries	discovery	NNS
cord-000372-wzwpyvll	87	5	concerning	concern	VBG
cord-000372-wzwpyvll	87	6	animal	animal	NN
cord-000372-wzwpyvll	87	7	viruses	virus	NNS
cord-000372-wzwpyvll	87	8	with	with	IN
cord-000372-wzwpyvll	87	9	RNA	RNA	NNP
cord-000372-wzwpyvll	87	10	genomes	genome	NNS
cord-000372-wzwpyvll	87	11	were	be	VBD
cord-000372-wzwpyvll	87	12	initially	initially	RB
cord-000372-wzwpyvll	87	13	made	make	VBN
cord-000372-wzwpyvll	87	14	in	in	IN
cord-000372-wzwpyvll	87	15	PV	PV	NNP
cord-000372-wzwpyvll	87	16	.	.	.
cord-000372-wzwpyvll	88	1	For	for	IN
cord-000372-wzwpyvll	88	2	example	example	NN
cord-000372-wzwpyvll	88	3	,	,	,
cord-000372-wzwpyvll	88	4	the	the	DT
cord-000372-wzwpyvll	88	5	presence	presence	NN
cord-000372-wzwpyvll	88	6	of	of	IN
cord-000372-wzwpyvll	88	7	uncapped	uncapped	JJ
cord-000372-wzwpyvll	88	8	mRNA	mRNA	NNP
cord-000372-wzwpyvll	88	9	,	,	,
cord-000372-wzwpyvll	88	10	the	the	DT
cord-000372-wzwpyvll	88	11	sequencing	sequencing	NN
cord-000372-wzwpyvll	88	12	and	and	CC
cord-000372-wzwpyvll	88	13	development	development	NN
cord-000372-wzwpyvll	88	14	of	of	IN
cord-000372-wzwpyvll	88	15	an	an	DT
cord-000372-wzwpyvll	88	16	infectious	infectious	JJ
cord-000372-wzwpyvll	88	17	cDNA	cdna	NN
cord-000372-wzwpyvll	88	18	clone	clone	NN
cord-000372-wzwpyvll	88	19	,	,	,
cord-000372-wzwpyvll	88	20	the	the	DT
cord-000372-wzwpyvll	88	21	three	three	CD
cord-000372-wzwpyvll	88	22	-	-	HYPH
cord-000372-wzwpyvll	88	23	dimensional	dimensional	JJ
cord-000372-wzwpyvll	88	24	structure	structure	NN
cord-000372-wzwpyvll	88	25	of	of	IN
cord-000372-wzwpyvll	88	26	a	a	DT
cord-000372-wzwpyvll	88	27	virus	virus	NN
cord-000372-wzwpyvll	88	28	particle	particle	NN
cord-000372-wzwpyvll	88	29	,	,	,
cord-000372-wzwpyvll	88	30	the	the	DT
cord-000372-wzwpyvll	88	31	discovery	discovery	NN
cord-000372-wzwpyvll	88	32	of	of	IN
cord-000372-wzwpyvll	88	33	the	the	DT
cord-000372-wzwpyvll	88	34	IRES	IRES	NNP
cord-000372-wzwpyvll	88	35	elements	element	NNS
cord-000372-wzwpyvll	88	36	,	,	,
cord-000372-wzwpyvll	88	37	the	the	DT
cord-000372-wzwpyvll	88	38	synthesis	synthesis	NN
cord-000372-wzwpyvll	88	39	of	of	IN
cord-000372-wzwpyvll	88	40	an	an	DT
cord-000372-wzwpyvll	88	41	infectious	infectious	JJ
cord-000372-wzwpyvll	88	42	virus	virus	NN
cord-000372-wzwpyvll	88	43	in	in	IN
cord-000372-wzwpyvll	88	44	a	a	DT
cord-000372-wzwpyvll	88	45	cell	cell	NN
cord-000372-wzwpyvll	88	46	-	-	HYPH
cord-000372-wzwpyvll	88	47	free	free	JJ
cord-000372-wzwpyvll	88	48	system	system	NN
cord-000372-wzwpyvll	88	49	,	,	,
cord-000372-wzwpyvll	88	50	the	the	DT
cord-000372-wzwpyvll	88	51	chemical	chemical	JJ
cord-000372-wzwpyvll	88	52	synthesis	synthesis	NN
cord-000372-wzwpyvll	88	53	of	of	IN
cord-000372-wzwpyvll	88	54	a	a	DT
cord-000372-wzwpyvll	88	55	complete	complete	JJ
cord-000372-wzwpyvll	88	56	viral	viral	JJ
cord-000372-wzwpyvll	88	57	genomes	genome	NNS
cord-000372-wzwpyvll	88	58	,	,	,
cord-000372-wzwpyvll	88	59	among	among	IN
cord-000372-wzwpyvll	88	60	others	other	NNS
cord-000372-wzwpyvll	88	61	,	,	,
cord-000372-wzwpyvll	88	62	were	be	VBD
cord-000372-wzwpyvll	88	63	initially	initially	RB
cord-000372-wzwpyvll	88	64	reported	report	VBN
cord-000372-wzwpyvll	88	65	in	in	IN
cord-000372-wzwpyvll	88	66	PV	PV	NNP
cord-000372-wzwpyvll	88	67	[	[	-LRB-
cord-000372-wzwpyvll	88	68	34	34	CD
cord-000372-wzwpyvll	88	69	]	]	-RRB-
cord-000372-wzwpyvll	88	70	[	[	-LRB-
cord-000372-wzwpyvll	88	71	35	35	CD
cord-000372-wzwpyvll	88	72	]	]	-RRB-
cord-000372-wzwpyvll	88	73	[	[	-LRB-
cord-000372-wzwpyvll	88	74	36	36	CD
cord-000372-wzwpyvll	88	75	]	]	-RRB-
cord-000372-wzwpyvll	88	76	[	[	-LRB-
cord-000372-wzwpyvll	88	77	37	37	CD
cord-000372-wzwpyvll	88	78	]	]	-RRB-
cord-000372-wzwpyvll	88	79	[	[	-LRB-
cord-000372-wzwpyvll	88	80	38	38	CD
cord-000372-wzwpyvll	88	81	]	]	-RRB-
cord-000372-wzwpyvll	88	82	.	.	.
cord-000372-wzwpyvll	89	1	In	in	IN
cord-000372-wzwpyvll	89	2	addition	addition	NN
cord-000372-wzwpyvll	89	3	,	,	,
cord-000372-wzwpyvll	89	4	the	the	DT
cord-000372-wzwpyvll	89	5	first	first	JJ
cord-000372-wzwpyvll	89	6	time	time	NN
cord-000372-wzwpyvll	89	7	that	that	WDT
cord-000372-wzwpyvll	89	8	eIF4	eIF4	NNP
cord-000372-wzwpyvll	89	9	G	G	NNP
cord-000372-wzwpyvll	89	10	was	be	VBD
cord-000372-wzwpyvll	89	11	found	find	VBN
cord-000372-wzwpyvll	89	12	proteolytically	proteolytically	RB
cord-000372-wzwpyvll	89	13	cleaved	cleave	VBN
cord-000372-wzwpyvll	89	14	was	be	VBD
cord-000372-wzwpyvll	89	15	in	in	IN
cord-000372-wzwpyvll	89	16	PV	pv	NN
cord-000372-wzwpyvll	89	17	-	-	HYPH
cord-000372-wzwpyvll	89	18	infected	infect	VBN
cord-000372-wzwpyvll	89	19	cells	cell	NNS
cord-000372-wzwpyvll	89	20	[	[	-LRB-
cord-000372-wzwpyvll	89	21	39	39	CD
cord-000372-wzwpyvll	89	22	]	]	-RRB-
cord-000372-wzwpyvll	89	23	.	.	.
cord-000372-wzwpyvll	90	1	Picornaviruses	picornavirus	NNS
cord-000372-wzwpyvll	90	2	encode	encode	VBP
cord-000372-wzwpyvll	90	3	different	different	JJ
cord-000372-wzwpyvll	90	4	proteases	protease	NNS
cord-000372-wzwpyvll	90	5	depending	depend	VBG
cord-000372-wzwpyvll	90	6	on	on	IN
cord-000372-wzwpyvll	90	7	the	the	DT
cord-000372-wzwpyvll	90	8	virus	virus	NN
cord-000372-wzwpyvll	90	9	species	species	NN
cord-000372-wzwpyvll	90	10	although	although	IN
cord-000372-wzwpyvll	90	11	it	-PRON-	PRP
cord-000372-wzwpyvll	90	12	is	be	VBZ
cord-000372-wzwpyvll	90	13	common	common	JJ
cord-000372-wzwpyvll	90	14	to	to	IN
cord-000372-wzwpyvll	90	15	all	all	DT
cord-000372-wzwpyvll	90	16	of	of	IN
cord-000372-wzwpyvll	90	17	them	-PRON-	PRP
cord-000372-wzwpyvll	90	18	to	to	TO
cord-000372-wzwpyvll	90	19	encode	encode	VB
cord-000372-wzwpyvll	90	20	3C	3C	NNP
cord-000372-wzwpyvll	90	21	pro	pro	NNP
cord-000372-wzwpyvll	90	22	and	and	CC
cord-000372-wzwpyvll	90	23	its	-PRON-	PRP$
cord-000372-wzwpyvll	90	24	precursor	precursor	NN
cord-000372-wzwpyvll	90	25	3CD	3cd	CD
cord-000372-wzwpyvll	90	26	pro	pro	JJ
cord-000372-wzwpyvll	90	27	(	(	-LRB-
cord-000372-wzwpyvll	90	28	Figure	figure	NN
cord-000372-wzwpyvll	90	29	2	2	CD
cord-000372-wzwpyvll	90	30	)	)	-RRB-
cord-000372-wzwpyvll	90	31	.	.	.
cord-000372-wzwpyvll	91	1	In	in	IN
cord-000372-wzwpyvll	91	2	PV	PV	NNP
cord-000372-wzwpyvll	91	3	,	,	,
cord-000372-wzwpyvll	91	4	both	both	CC
cord-000372-wzwpyvll	91	5	these	these	DT
cord-000372-wzwpyvll	91	6	exhibit	exhibit	NN
cord-000372-wzwpyvll	91	7	protease	protease	NN
cord-000372-wzwpyvll	91	8	activity	activity	NN
cord-000372-wzwpyvll	91	9	,	,	,
cord-000372-wzwpyvll	91	10	and	and	CC
cord-000372-wzwpyvll	91	11	they	-PRON-	PRP
cord-000372-wzwpyvll	91	12	execute	execute	VBP
cord-000372-wzwpyvll	91	13	most	most	JJS
cord-000372-wzwpyvll	91	14	of	of	IN
cord-000372-wzwpyvll	91	15	the	the	DT
cord-000372-wzwpyvll	91	16	hydrolytic	hydrolytic	JJ
cord-000372-wzwpyvll	91	17	events	event	NNS
cord-000372-wzwpyvll	91	18	on	on	IN
cord-000372-wzwpyvll	91	19	the	the	DT
cord-000372-wzwpyvll	91	20	viral	viral	JJ
cord-000372-wzwpyvll	91	21	polyprotein	polyprotein	NN
cord-000372-wzwpyvll	91	22	[	[	-LRB-
cord-000372-wzwpyvll	91	23	2	2	CD
cord-000372-wzwpyvll	91	24	,	,	,
cord-000372-wzwpyvll	91	25	23	23	CD
cord-000372-wzwpyvll	91	26	,	,	,
cord-000372-wzwpyvll	91	27	40	40	CD
cord-000372-wzwpyvll	91	28	]	]	-RRB-
cord-000372-wzwpyvll	91	29	.	.	.
cord-000372-wzwpyvll	92	1	Apart	apart	RB
cord-000372-wzwpyvll	92	2	from	from	IN
cord-000372-wzwpyvll	92	3	these	these	DT
cord-000372-wzwpyvll	92	4	two	two	CD
cord-000372-wzwpyvll	92	5	proteases	protease	NNS
cord-000372-wzwpyvll	92	6	,	,	,
cord-000372-wzwpyvll	92	7	3C	3C	NNP
cord-000372-wzwpyvll	92	8	pro	pro	NNP
cord-000372-wzwpyvll	92	9	and	and	CC
cord-000372-wzwpyvll	92	10	3CD	3CD	NNP
cord-000372-wzwpyvll	92	11	pro	pro	NNP
cord-000372-wzwpyvll	92	12	,	,	,
cord-000372-wzwpyvll	92	13	picornaviruses	picornavirus	NNS
cord-000372-wzwpyvll	92	14	also	also	RB
cord-000372-wzwpyvll	92	15	contain	contain	VBP
cord-000372-wzwpyvll	92	16	a	a	DT
cord-000372-wzwpyvll	92	17	2A	2a	CD
cord-000372-wzwpyvll	92	18	gene	gene	NN
cord-000372-wzwpyvll	92	19	,	,	,
cord-000372-wzwpyvll	92	20	whose	whose	WP$
cord-000372-wzwpyvll	92	21	product	product	NN
cord-000372-wzwpyvll	92	22	in	in	IN
cord-000372-wzwpyvll	92	23	some	some	DT
cord-000372-wzwpyvll	92	24	species	specie	NNS
cord-000372-wzwpyvll	92	25	exhibits	exhibit	VBZ
cord-000372-wzwpyvll	92	26	proteolytic	proteolytic	JJ
cord-000372-wzwpyvll	92	27	activity	activity	NN
cord-000372-wzwpyvll	92	28	,	,	,
cord-000372-wzwpyvll	92	29	as	as	IN
cord-000372-wzwpyvll	92	30	is	be	VBZ
cord-000372-wzwpyvll	92	31	the	the	DT
cord-000372-wzwpyvll	92	32	case	case	NN
cord-000372-wzwpyvll	92	33	for	for	IN
cord-000372-wzwpyvll	92	34	PV	pv	NN
cord-000372-wzwpyvll	92	35	(	(	-LRB-
cord-000372-wzwpyvll	92	36	Figure	figure	NN
cord-000372-wzwpyvll	92	37	2	2	CD
cord-000372-wzwpyvll	92	38	)	)	-RRB-
cord-000372-wzwpyvll	92	39	.	.	.
cord-000372-wzwpyvll	93	1	2A	2A	NNP
cord-000372-wzwpyvll	93	2	pro	pro	NNP
cord-000372-wzwpyvll	93	3	has	have	VBZ
cord-000372-wzwpyvll	93	4	a	a	DT
cord-000372-wzwpyvll	93	5	limited	limited	JJ
cord-000372-wzwpyvll	93	6	proteolytic	proteolytic	JJ
cord-000372-wzwpyvll	93	7	effect	effect	NN
cord-000372-wzwpyvll	93	8	on	on	IN
cord-000372-wzwpyvll	93	9	the	the	DT
cord-000372-wzwpyvll	93	10	polyprotein	polyprotein	NN
cord-000372-wzwpyvll	93	11	and	and	CC
cord-000372-wzwpyvll	93	12	its	-PRON-	PRP$
cord-000372-wzwpyvll	93	13	function	function	NN
cord-000372-wzwpyvll	93	14	is	be	VBZ
cord-000372-wzwpyvll	93	15	most	most	RBS
cord-000372-wzwpyvll	93	16	probably	probably	RB
cord-000372-wzwpyvll	93	17	one	one	CD
cord-000372-wzwpyvll	93	18	of	of	IN
cord-000372-wzwpyvll	93	19	altering	alter	VBG
cord-000372-wzwpyvll	93	20	cellular	cellular	JJ
cord-000372-wzwpyvll	93	21	functions	function	NNS
cord-000372-wzwpyvll	93	22	by	by	IN
cord-000372-wzwpyvll	93	23	the	the	DT
cord-000372-wzwpyvll	93	24	cleavage	cleavage	NN
cord-000372-wzwpyvll	93	25	of	of	IN
cord-000372-wzwpyvll	93	26	a	a	DT
cord-000372-wzwpyvll	93	27	number	number	NN
cord-000372-wzwpyvll	93	28	of	of	IN
cord-000372-wzwpyvll	93	29	cellular	cellular	JJ
cord-000372-wzwpyvll	93	30	proteins	protein	NNS
cord-000372-wzwpyvll	93	31	.	.	.
cord-000372-wzwpyvll	94	1	In	in	IN
cord-000372-wzwpyvll	94	2	this	this	DT
cord-000372-wzwpyvll	94	3	regard	regard	NN
cord-000372-wzwpyvll	94	4	,	,	,
cord-000372-wzwpyvll	94	5	the	the	DT
cord-000372-wzwpyvll	94	6	best	well	RBS
cord-000372-wzwpyvll	94	7	studied	study	VBN
cord-000372-wzwpyvll	94	8	of	of	IN
cord-000372-wzwpyvll	94	9	these	these	DT
cord-000372-wzwpyvll	94	10	cleavages	cleavage	NNS
cord-000372-wzwpyvll	94	11	is	be	VBZ
cord-000372-wzwpyvll	94	12	the	the	DT
cord-000372-wzwpyvll	94	13	bisection	bisection	NN
cord-000372-wzwpyvll	94	14	of	of	IN
cord-000372-wzwpyvll	94	15	eIF4	eIF4	NNP
cord-000372-wzwpyvll	94	16	G	G	NNP
cord-000372-wzwpyvll	94	17	(	(	-LRB-
cord-000372-wzwpyvll	94	18	Figure	figure	NN
cord-000372-wzwpyvll	94	19	3	3	CD
cord-000372-wzwpyvll	94	20	)	)	-RRB-
cord-000372-wzwpyvll	94	21	[	[	-LRB-
cord-000372-wzwpyvll	94	22	14	14	CD
cord-000372-wzwpyvll	94	23	]	]	-RRB-
cord-000372-wzwpyvll	94	24	.	.	.
cord-000372-wzwpyvll	95	1	The	the	DT
cord-000372-wzwpyvll	95	2	general	general	JJ
cord-000372-wzwpyvll	95	3	organization	organization	NN
cord-000372-wzwpyvll	95	4	of	of	IN
cord-000372-wzwpyvll	95	5	the	the	DT
cord-000372-wzwpyvll	95	6	picornavirus	picornavirus	NNP
cord-000372-wzwpyvll	95	7	genomes	genome	NNS
cord-000372-wzwpyvll	95	8	is	be	VBZ
cord-000372-wzwpyvll	95	9	to	to	TO
cord-000372-wzwpyvll	95	10	encode	encode	VB
cord-000372-wzwpyvll	95	11	for	for	IN
cord-000372-wzwpyvll	95	12	P1-P2-P3	P1-P2-P3	NNP
cord-000372-wzwpyvll	95	13	precursors	precursor	NNS
cord-000372-wzwpyvll	95	14	giving	give	VBG
cord-000372-wzwpyvll	95	15	rise	rise	NN
cord-000372-wzwpyvll	95	16	to	to	IN
cord-000372-wzwpyvll	95	17	4	4	CD
cord-000372-wzwpyvll	95	18	-	-	SYM
cord-000372-wzwpyvll	95	19	3	3	CD
cord-000372-wzwpyvll	95	20	-	-	SYM
cord-000372-wzwpyvll	95	21	4	4	CD
cord-000372-wzwpyvll	95	22	mature	mature	JJ
cord-000372-wzwpyvll	95	23	products	product	NNS
cord-000372-wzwpyvll	95	24	.	.	.
cord-000372-wzwpyvll	96	1	Some	some	DT
cord-000372-wzwpyvll	96	2	picornavirus	picornavirus	NN
cord-000372-wzwpyvll	96	3	species	specie	NNS
cord-000372-wzwpyvll	96	4	,	,	,
cord-000372-wzwpyvll	96	5	in	in	IN
cord-000372-wzwpyvll	96	6	addition	addition	NN
cord-000372-wzwpyvll	96	7	,	,	,
cord-000372-wzwpyvll	96	8	encode	encode	VB
cord-000372-wzwpyvll	96	9	a	a	DT
cord-000372-wzwpyvll	96	10	leader	leader	NN
cord-000372-wzwpyvll	96	11	protein	protein	NN
cord-000372-wzwpyvll	96	12	(	(	-LRB-
cord-000372-wzwpyvll	96	13	L	L	NNP
cord-000372-wzwpyvll	96	14	)	)	-RRB-
cord-000372-wzwpyvll	96	15	placed	place	VBN
cord-000372-wzwpyvll	96	16	before	before	IN
cord-000372-wzwpyvll	96	17	P1	P1	NNP
cord-000372-wzwpyvll	96	18	(	(	-LRB-
cord-000372-wzwpyvll	96	19	Figure	figure	NN
cord-000372-wzwpyvll	96	20	2	2	CD
cord-000372-wzwpyvll	96	21	)	)	-RRB-
cord-000372-wzwpyvll	96	22	[	[	-LRB-
cord-000372-wzwpyvll	96	23	22	22	CD
cord-000372-wzwpyvll	96	24	]	]	-RRB-
cord-000372-wzwpyvll	96	25	.	.	.
cord-000372-wzwpyvll	97	1	In	in	IN
cord-000372-wzwpyvll	97	2	the	the	DT
cord-000372-wzwpyvll	97	3	case	case	NN
cord-000372-wzwpyvll	97	4	of	of	IN
cord-000372-wzwpyvll	97	5	aphthoviruses	aphthoviruse	NNS
cord-000372-wzwpyvll	97	6	,	,	,
cord-000372-wzwpyvll	97	7	such	such	JJ
cord-000372-wzwpyvll	97	8	as	as	IN
cord-000372-wzwpyvll	97	9	foot	foot	NN
cord-000372-wzwpyvll	97	10	-	-	HYPH
cord-000372-wzwpyvll	97	11	and	and	CC
cord-000372-wzwpyvll	97	12	-	-	HYPH
cord-000372-wzwpyvll	97	13	mouth	mouth	NN
cord-000372-wzwpyvll	97	14	disease	disease	NN
cord-000372-wzwpyvll	97	15	virus	virus	NN
cord-000372-wzwpyvll	97	16	(	(	-LRB-
cord-000372-wzwpyvll	97	17	FMDV	FMDV	NNP
cord-000372-wzwpyvll	97	18	)	)	-RRB-
cord-000372-wzwpyvll	97	19	,	,	,
cord-000372-wzwpyvll	97	20	the	the	DT
cord-000372-wzwpyvll	97	21	L	L	NNP
cord-000372-wzwpyvll	97	22	protein	protein	NN
cord-000372-wzwpyvll	97	23	has	have	VBZ
cord-000372-wzwpyvll	97	24	proteolytic	proteolytic	JJ
cord-000372-wzwpyvll	97	25	activity	activity	NN
cord-000372-wzwpyvll	97	26	and	and	CC
cord-000372-wzwpyvll	97	27	it	-PRON-	PRP
cord-000372-wzwpyvll	97	28	is	be	VBZ
cord-000372-wzwpyvll	97	29	known	know	VBN
cord-000372-wzwpyvll	97	30	as	as	IN
cord-000372-wzwpyvll	97	31	L	L	NNP
cord-000372-wzwpyvll	97	32	pro	pro	JJ
cord-000372-wzwpyvll	97	33	[	[	-LRB-
cord-000372-wzwpyvll	97	34	42	42	CD
cord-000372-wzwpyvll	97	35	,	,	,
cord-000372-wzwpyvll	97	36	43	43	CD
cord-000372-wzwpyvll	97	37	]	]	-RRB-
cord-000372-wzwpyvll	97	38	.	.	.
cord-000372-wzwpyvll	98	1	During	during	IN
cord-000372-wzwpyvll	98	2	polyprotein	polyprotein	JJ
cord-000372-wzwpyvll	98	3	synthesis	synthesis	NN
cord-000372-wzwpyvll	98	4	L	L	NNP
cord-000372-wzwpyvll	98	5	pro	pro	NNP
cord-000372-wzwpyvll	98	6	is	be	VBZ
cord-000372-wzwpyvll	98	7	the	the	DT
cord-000372-wzwpyvll	98	8	first	first	JJ
cord-000372-wzwpyvll	98	9	protein	protein	NN
cord-000372-wzwpyvll	98	10	synthesized	synthesize	VBN
cord-000372-wzwpyvll	98	11	and	and	CC
cord-000372-wzwpyvll	98	12	its	-PRON-	PRP$
cord-000372-wzwpyvll	98	13	autoproteolytic	autoproteolytic	JJ
cord-000372-wzwpyvll	98	14	activity	activity	NN
cord-000372-wzwpyvll	98	15	releases	release	VBZ
cord-000372-wzwpyvll	98	16	itself	-PRON-	PRP
cord-000372-wzwpyvll	98	17	from	from	IN
cord-000372-wzwpyvll	98	18	the	the	DT
cord-000372-wzwpyvll	98	19	rest	rest	NN
cord-000372-wzwpyvll	98	20	of	of	IN
cord-000372-wzwpyvll	98	21	the	the	DT
cord-000372-wzwpyvll	98	22	polypeptide	polypeptide	NN
cord-000372-wzwpyvll	98	23	chain	chain	NN
cord-000372-wzwpyvll	98	24	.	.	.
cord-000372-wzwpyvll	99	1	Thus	thus	RB
cord-000372-wzwpyvll	99	2	,	,	,
cord-000372-wzwpyvll	99	3	the	the	DT
cord-000372-wzwpyvll	99	4	only	only	RB
cord-000372-wzwpyvll	99	5	known	know	VBN
cord-000372-wzwpyvll	99	6	hydrolysis	hydrolysis	NN
cord-000372-wzwpyvll	99	7	executed	execute	VBN
cord-000372-wzwpyvll	99	8	by	by	IN
cord-000372-wzwpyvll	99	9	L	L	NNP
cord-000372-wzwpyvll	99	10	pro	pro	NNP
cord-000372-wzwpyvll	99	11	on	on	IN
cord-000372-wzwpyvll	99	12	the	the	DT
cord-000372-wzwpyvll	99	13	polyprotein	polyprotein	NN
cord-000372-wzwpyvll	99	14	is	be	VBZ
cord-000372-wzwpyvll	99	15	to	to	TO
cord-000372-wzwpyvll	99	16	hydrolyze	hydrolyze	VB
cord-000372-wzwpyvll	99	17	between	between	IN
cord-000372-wzwpyvll	99	18	its	-PRON-	PRP$
cord-000372-wzwpyvll	99	19	carboxy	carboxy	JJ
cord-000372-wzwpyvll	99	20	terminus	terminus	NN
cord-000372-wzwpyvll	99	21	and	and	CC
cord-000372-wzwpyvll	99	22	the	the	DT
cord-000372-wzwpyvll	99	23	amino	amino	NN
cord-000372-wzwpyvll	99	24	terminus	terminus	NN
cord-000372-wzwpyvll	99	25	of	of	IN
cord-000372-wzwpyvll	99	26	VP4	VP4	NNP
cord-000372-wzwpyvll	99	27	(	(	-LRB-
cord-000372-wzwpyvll	99	28	Figure	figure	NN
cord-000372-wzwpyvll	99	29	2	2	CD
cord-000372-wzwpyvll	99	30	)	)	-RRB-
cord-000372-wzwpyvll	99	31	.	.	.
cord-000372-wzwpyvll	100	1	Because	because	IN
cord-000372-wzwpyvll	100	2	L	L	NNP
cord-000372-wzwpyvll	100	3	pro	pro	JJ
cord-000372-wzwpyvll	100	4	does	do	VBZ
cord-000372-wzwpyvll	100	5	not	not	RB
cord-000372-wzwpyvll	100	6	play	play	VB
cord-000372-wzwpyvll	100	7	a	a	DT
cord-000372-wzwpyvll	100	8	direct	direct	JJ
cord-000372-wzwpyvll	100	9	role	role	NN
cord-000372-wzwpyvll	100	10	in	in	IN
cord-000372-wzwpyvll	100	11	viral	viral	JJ
cord-000372-wzwpyvll	100	12	replication	replication	NN
cord-000372-wzwpyvll	100	13	[	[	-LRB-
cord-000372-wzwpyvll	100	14	44	44	CD
cord-000372-wzwpyvll	100	15	]	]	-RRB-
cord-000372-wzwpyvll	100	16	and	and	CC
cord-000372-wzwpyvll	100	17	its	-PRON-	PRP$
cord-000372-wzwpyvll	100	18	protease	protease	NN
cord-000372-wzwpyvll	100	19	activity	activity	NN
cord-000372-wzwpyvll	100	20	has	have	VBZ
cord-000372-wzwpyvll	100	21	a	a	DT
cord-000372-wzwpyvll	100	22	limited	limited	JJ
cord-000372-wzwpyvll	100	23	impact	impact	NN
cord-000372-wzwpyvll	100	24	in	in	IN
cord-000372-wzwpyvll	100	25	the	the	DT
cord-000372-wzwpyvll	100	26	viral	viral	JJ
cord-000372-wzwpyvll	100	27	polyprotein	polyprotein	NN
cord-000372-wzwpyvll	100	28	,	,	,
cord-000372-wzwpyvll	100	29	this	this	DT
cord-000372-wzwpyvll	100	30	protease	protease	NN
cord-000372-wzwpyvll	100	31	may	may	MD
cord-000372-wzwpyvll	100	32	be	be	VB
cord-000372-wzwpyvll	100	33	involved	involve	VBN
cord-000372-wzwpyvll	100	34	in	in	IN
cord-000372-wzwpyvll	100	35	the	the	DT
cord-000372-wzwpyvll	100	36	interaction	interaction	NN
cord-000372-wzwpyvll	100	37	with	with	IN
cord-000372-wzwpyvll	100	38	the	the	DT
cord-000372-wzwpyvll	100	39	hostcell	hostcell	NNP
cord-000372-wzwpyvll	100	40	[	[	-LRB-
cord-000372-wzwpyvll	100	41	45	45	CD
cord-000372-wzwpyvll	100	42	]	]	-RRB-
cord-000372-wzwpyvll	101	1	[	[	-LRB-
cord-000372-wzwpyvll	101	2	46	46	CD
cord-000372-wzwpyvll	101	3	]	]	-RRB-
cord-000372-wzwpyvll	101	4	[	[	-LRB-
cord-000372-wzwpyvll	101	5	47	47	CD
cord-000372-wzwpyvll	101	6	]	]	-RRB-
cord-000372-wzwpyvll	101	7	.	.	.
cord-000372-wzwpyvll	102	1	Indeed	indeed	RB
cord-000372-wzwpyvll	102	2	,	,	,
cord-000372-wzwpyvll	102	3	L	L	NNP
cord-000372-wzwpyvll	102	4	pro	pro	NNP
cord-000372-wzwpyvll	102	5	also	also	RB
cord-000372-wzwpyvll	102	6	exhibits	exhibit	VBZ
cord-000372-wzwpyvll	102	7	proteolytic	proteolytic	JJ
cord-000372-wzwpyvll	102	8	activity	activity	NN
cord-000372-wzwpyvll	102	9	on	on	IN
cord-000372-wzwpyvll	102	10	eIF4	eIF4	NNP
cord-000372-wzwpyvll	102	11	G	g	NN
cord-000372-wzwpyvll	102	12	acting	act	VBG
cord-000372-wzwpyvll	102	13	at	at	IN
cord-000372-wzwpyvll	102	14	a	a	DT
cord-000372-wzwpyvll	102	15	position	position	NN
cord-000372-wzwpyvll	102	16	close	close	JJ
cord-000372-wzwpyvll	102	17	to	to	IN
cord-000372-wzwpyvll	102	18	that	that	DT
cord-000372-wzwpyvll	102	19	of	of	IN
cord-000372-wzwpyvll	102	20	PV	PV	NNP
cord-000372-wzwpyvll	102	21	2A	2a	CD
cord-000372-wzwpyvll	102	22	pro	pro	JJ
cord-000372-wzwpyvll	102	23	(	(	-LRB-
cord-000372-wzwpyvll	102	24	Figure	figure	NN
cord-000372-wzwpyvll	102	25	3	3	CD
cord-000372-wzwpyvll	102	26	)	)	-RRB-
cord-000372-wzwpyvll	103	1	[	[	-LRB-
cord-000372-wzwpyvll	103	2	48	48	CD
cord-000372-wzwpyvll	103	3	]	]	-RRB-
cord-000372-wzwpyvll	104	1	[	[	-LRB-
cord-000372-wzwpyvll	104	2	49	49	CD
cord-000372-wzwpyvll	104	3	]	]	-RRB-
cord-000372-wzwpyvll	104	4	[	[	-LRB-
cord-000372-wzwpyvll	104	5	50	50	CD
cord-000372-wzwpyvll	104	6	]	]	-RRB-
cord-000372-wzwpyvll	104	7	.	.	.
cord-000372-wzwpyvll	105	1	In	in	IN
cord-000372-wzwpyvll	105	2	the	the	DT
cord-000372-wzwpyvll	105	3	case	case	NN
cord-000372-wzwpyvll	105	4	of	of	IN
cord-000372-wzwpyvll	105	5	FMDV	FMDV	NNP
cord-000372-wzwpyvll	105	6	,	,	,
cord-000372-wzwpyvll	105	7	the	the	DT
cord-000372-wzwpyvll	105	8	2A	2A	NNP
cord-000372-wzwpyvll	105	9	protein	protein	NN
cord-000372-wzwpyvll	105	10	is	be	VBZ
cord-000372-wzwpyvll	105	11	reduced	reduce	VBN
cord-000372-wzwpyvll	105	12	to	to	IN
cord-000372-wzwpyvll	105	13	a	a	DT
cord-000372-wzwpyvll	105	14	small	small	JJ
cord-000372-wzwpyvll	105	15	peptide	peptide	NN
cord-000372-wzwpyvll	105	16	of	of	IN
cord-000372-wzwpyvll	105	17	18	18	CD
cord-000372-wzwpyvll	105	18	residues	residue	NNS
cord-000372-wzwpyvll	105	19	that	that	WDT
cord-000372-wzwpyvll	105	20	does	do	VBZ
cord-000372-wzwpyvll	105	21	not	not	RB
cord-000372-wzwpyvll	105	22	hydrolyze	hydrolyze	VB
cord-000372-wzwpyvll	105	23	eIF4	eif4	IN
cord-000372-wzwpyvll	105	24	G	g	NN
cord-000372-wzwpyvll	105	25	;	;	:
cord-000372-wzwpyvll	105	26	instead	instead	RB
cord-000372-wzwpyvll	105	27	it	-PRON-	PRP
cord-000372-wzwpyvll	105	28	induces	induce	VBZ
cord-000372-wzwpyvll	105	29	the	the	DT
cord-000372-wzwpyvll	105	30	release	release	NN
cord-000372-wzwpyvll	105	31	of	of	IN
cord-000372-wzwpyvll	105	32	2A	2a	CD
cord-000372-wzwpyvll	105	33	from	from	IN
cord-000372-wzwpyvll	105	34	its	-PRON-	PRP$
cord-000372-wzwpyvll	105	35	carboxy	carboxy	JJ
cord-000372-wzwpyvll	105	36	terminus	terminus	NN
cord-000372-wzwpyvll	105	37	by	by	IN
cord-000372-wzwpyvll	105	38	a	a	DT
cord-000372-wzwpyvll	105	39	ribosomal	ribosomal	NN
cord-000372-wzwpyvll	105	40	skip	skip	NN
cord-000372-wzwpyvll	105	41	mechanism	mechanism	NN
cord-000372-wzwpyvll	105	42	[	[	-LRB-
cord-000372-wzwpyvll	105	43	51	51	CD
cord-000372-wzwpyvll	105	44	,	,	,
cord-000372-wzwpyvll	105	45	52	52	CD
cord-000372-wzwpyvll	105	46	]	]	-RRB-
cord-000372-wzwpyvll	105	47	.	.	.
cord-000372-wzwpyvll	106	1	This	this	DT
cord-000372-wzwpyvll	106	2	model	model	NN
cord-000372-wzwpyvll	106	3	proposes	propose	VBZ
cord-000372-wzwpyvll	106	4	that	that	IN
cord-000372-wzwpyvll	106	5	FMDV	FMDV	NNP
cord-000372-wzwpyvll	106	6	2A	2a	NN
cord-000372-wzwpyvll	106	7	modifies	modify	VBZ
cord-000372-wzwpyvll	106	8	the	the	DT
cord-000372-wzwpyvll	106	9	activity	activity	NN
cord-000372-wzwpyvll	106	10	of	of	IN
cord-000372-wzwpyvll	106	11	the	the	DT
cord-000372-wzwpyvll	106	12	ribosome	ribosome	NN
cord-000372-wzwpyvll	106	13	to	to	TO
cord-000372-wzwpyvll	106	14	promote	promote	VB
cord-000372-wzwpyvll	106	15	hydrolysis	hydrolysis	NN
cord-000372-wzwpyvll	106	16	of	of	IN
cord-000372-wzwpyvll	106	17	the	the	DT
cord-000372-wzwpyvll	106	18	peptidyl(2A)-tRNA(Gly	peptidyl(2A)-tRNA(Gly	NNP
cord-000372-wzwpyvll	106	19	)	)	-RRB-
cord-000372-wzwpyvll	106	20	ester	ester	NN
cord-000372-wzwpyvll	106	21	linkage	linkage	NN
cord-000372-wzwpyvll	106	22	at	at	IN
cord-000372-wzwpyvll	106	23	the	the	DT
cord-000372-wzwpyvll	106	24	C	C	NNP
cord-000372-wzwpyvll	106	25	-	-	HYPH
cord-000372-wzwpyvll	106	26	terminus	terminus	NN
cord-000372-wzwpyvll	106	27	of	of	IN
cord-000372-wzwpyvll	106	28	2A	2a	CD
cord-000372-wzwpyvll	106	29	,	,	,
cord-000372-wzwpyvll	106	30	thereby	thereby	RB
cord-000372-wzwpyvll	106	31	releasing	release	VBG
cord-000372-wzwpyvll	106	32	the	the	DT
cord-000372-wzwpyvll	106	33	polypeptide	polypeptide	NN
cord-000372-wzwpyvll	106	34	from	from	IN
cord-000372-wzwpyvll	106	35	the	the	DT
cord-000372-wzwpyvll	106	36	translational	translational	JJ
cord-000372-wzwpyvll	106	37	complex	complex	NN
cord-000372-wzwpyvll	106	38	.	.	.
cord-000372-wzwpyvll	107	1	However	however	RB
cord-000372-wzwpyvll	107	2	,	,	,
cord-000372-wzwpyvll	107	3	not	not	RB
cord-000372-wzwpyvll	107	4	all	all	DT
cord-000372-wzwpyvll	107	5	L	l	NN
cord-000372-wzwpyvll	107	6	or	or	CC
cord-000372-wzwpyvll	107	7	2A	2a	NN
cord-000372-wzwpyvll	107	8	proteins	protein	NNS
cord-000372-wzwpyvll	107	9	from	from	IN
cord-000372-wzwpyvll	107	10	picornaviruses	picornaviruses	NNP
cord-000372-wzwpyvll	107	11	exhibit	exhibit	NN
cord-000372-wzwpyvll	107	12	protease	protease	NN
cord-000372-wzwpyvll	107	13	activity	activity	NN
cord-000372-wzwpyvll	107	14	,	,	,
cord-000372-wzwpyvll	107	15	since	since	IN
cord-000372-wzwpyvll	107	16	in	in	IN
cord-000372-wzwpyvll	107	17	the	the	DT
cord-000372-wzwpyvll	107	18	case	case	NN
cord-000372-wzwpyvll	107	19	of	of	IN
cord-000372-wzwpyvll	107	20	EMCV	EMCV	NNP
cord-000372-wzwpyvll	107	21	,	,	,
cord-000372-wzwpyvll	107	22	which	which	WDT
cord-000372-wzwpyvll	107	23	encodes	encode	VBZ
cord-000372-wzwpyvll	107	24	both	both	DT
cord-000372-wzwpyvll	107	25	proteins	protein	NNS
cord-000372-wzwpyvll	107	26	,	,	,
cord-000372-wzwpyvll	107	27	neither	neither	CC
cord-000372-wzwpyvll	107	28	has	have	VBZ
cord-000372-wzwpyvll	107	29	been	be	VBN
cord-000372-wzwpyvll	107	30	demonstrated	demonstrate	VBN
cord-000372-wzwpyvll	107	31	to	to	TO
cord-000372-wzwpyvll	107	32	possess	possess	VB
cord-000372-wzwpyvll	107	33	proteolytic	proteolytic	JJ
cord-000372-wzwpyvll	107	34	activity	activity	NN
cord-000372-wzwpyvll	107	35	[	[	-LRB-
cord-000372-wzwpyvll	107	36	53	53	CD
cord-000372-wzwpyvll	107	37	]	]	-RRB-
cord-000372-wzwpyvll	107	38	.	.	.
cord-000372-wzwpyvll	108	1	All	all	DT
cord-000372-wzwpyvll	108	2	known	know	VBN
cord-000372-wzwpyvll	108	3	proteases	protease	NNS
cord-000372-wzwpyvll	108	4	have	have	VBP
cord-000372-wzwpyvll	108	5	been	be	VBN
cord-000372-wzwpyvll	108	6	classified	classify	VBN
cord-000372-wzwpyvll	108	7	in	in	IN
cord-000372-wzwpyvll	108	8	four	four	CD
cord-000372-wzwpyvll	108	9	classes	class	NNS
cord-000372-wzwpyvll	108	10	and	and	CC
cord-000372-wzwpyvll	108	11	many	many	JJ
cord-000372-wzwpyvll	108	12	subgroups	subgroup	NNS
cord-000372-wzwpyvll	108	13	according	accord	VBG
cord-000372-wzwpyvll	108	14	to	to	IN
cord-000372-wzwpyvll	108	15	three	three	CD
cord-000372-wzwpyvll	108	16	parameters	parameter	NNS
cord-000372-wzwpyvll	108	17	:	:	:
cord-000372-wzwpyvll	108	18	(	(	-LRB-
cord-000372-wzwpyvll	108	19	i	i	NN
cord-000372-wzwpyvll	108	20	)	)	-RRB-
cord-000372-wzwpyvll	108	21	their	-PRON-	PRP$
cord-000372-wzwpyvll	108	22	catalytic	catalytic	JJ
cord-000372-wzwpyvll	108	23	center	center	NN
cord-000372-wzwpyvll	108	24	,	,	,
cord-000372-wzwpyvll	108	25	(	(	-LRB-
cord-000372-wzwpyvll	108	26	ii	ii	NN
cord-000372-wzwpyvll	108	27	)	)	-RRB-
cord-000372-wzwpyvll	109	1	their	-PRON-	PRP$
cord-000372-wzwpyvll	109	2	substrate	substrate	NN
cord-000372-wzwpyvll	109	3	specificity	specificity	NN
cord-000372-wzwpyvll	109	4	,	,	,
cord-000372-wzwpyvll	109	5	and	and	CC
cord-000372-wzwpyvll	109	6	(	(	-LRB-
cord-000372-wzwpyvll	109	7	iii	iii	NN
cord-000372-wzwpyvll	109	8	)	)	-RRB-
cord-000372-wzwpyvll	110	1	their	-PRON-	PRP$
cord-000372-wzwpyvll	110	2	three	three	CD
cord-000372-wzwpyvll	110	3	-	-	HYPH
cord-000372-wzwpyvll	110	4	dimensional	dimensional	JJ
cord-000372-wzwpyvll	110	5	structure	structure	NN
cord-000372-wzwpyvll	110	6	.	.	.
cord-000372-wzwpyvll	111	1	The	the	DT
cord-000372-wzwpyvll	111	2	classification	classification	NN
cord-000372-wzwpyvll	111	3	of	of	IN
cord-000372-wzwpyvll	111	4	the	the	DT
cord-000372-wzwpyvll	111	5	different	different	JJ
cord-000372-wzwpyvll	111	6	picornavirus	picornavirus	NN
cord-000372-wzwpyvll	111	7	proteases	protease	NNS
cord-000372-wzwpyvll	111	8	initially	initially	RB
cord-000372-wzwpyvll	111	9	relied	rely	VBD
cord-000372-wzwpyvll	111	10	upon	upon	IN
cord-000372-wzwpyvll	111	11	the	the	DT
cord-000372-wzwpyvll	111	12	effect	effect	NN
cord-000372-wzwpyvll	111	13	of	of	IN
cord-000372-wzwpyvll	111	14	protease	protease	NN
cord-000372-wzwpyvll	111	15	inhibitors	inhibitor	NNS
cord-000372-wzwpyvll	111	16	.	.	.
cord-000372-wzwpyvll	112	1	Compounds	compound	NNS
cord-000372-wzwpyvll	112	2	that	that	WDT
cord-000372-wzwpyvll	112	3	blocked	block	VBD
cord-000372-wzwpyvll	112	4	sulphydryl	sulphydryl	NNP
cord-000372-wzwpyvll	112	5	groups	group	NNS
cord-000372-wzwpyvll	112	6	abrogated	abrogate	VBD
cord-000372-wzwpyvll	112	7	the	the	DT
cord-000372-wzwpyvll	112	8	proteolytic	proteolytic	JJ
cord-000372-wzwpyvll	112	9	activity	activity	NN
cord-000372-wzwpyvll	112	10	of	of	IN
cord-000372-wzwpyvll	112	11	2A	2a	CD
cord-000372-wzwpyvll	112	12	pro	pro	NNP
cord-000372-wzwpyvll	112	13	and	and	CC
cord-000372-wzwpyvll	112	14	3C	3C	NNP
cord-000372-wzwpyvll	112	15	pro	pro	NNP
cord-000372-wzwpyvll	112	16	,	,	,
cord-000372-wzwpyvll	112	17	suggesting	suggest	VBG
cord-000372-wzwpyvll	112	18	that	that	IN
cord-000372-wzwpyvll	112	19	the	the	DT
cord-000372-wzwpyvll	112	20	nucleophilic	nucleophilic	JJ
cord-000372-wzwpyvll	112	21	aminoacid	aminoacid	NNP
cord-000372-wzwpyvll	112	22	in	in	IN
cord-000372-wzwpyvll	112	23	the	the	DT
cord-000372-wzwpyvll	112	24	active	active	JJ
cord-000372-wzwpyvll	112	25	site	site	NN
cord-000372-wzwpyvll	112	26	was	be	VBD
cord-000372-wzwpyvll	112	27	cysteine	cysteine	NN
cord-000372-wzwpyvll	112	28	[	[	-LRB-
cord-000372-wzwpyvll	112	29	54	54	CD
cord-000372-wzwpyvll	112	30	,	,	,
cord-000372-wzwpyvll	112	31	55	55	CD
cord-000372-wzwpyvll	112	32	]	]	-RRB-
cord-000372-wzwpyvll	112	33	.	.	.
cord-000372-wzwpyvll	113	1	However	however	RB
cord-000372-wzwpyvll	113	2	,	,	,
cord-000372-wzwpyvll	113	3	another	another	DT
cord-000372-wzwpyvll	113	4	cysteine	cysteine	NN
cord-000372-wzwpyvll	113	5	inhibitor	inhibitor	NN
cord-000372-wzwpyvll	113	6	such	such	JJ
cord-000372-wzwpyvll	113	7	as	as	IN
cord-000372-wzwpyvll	113	8	E64	E64	NNP
cord-000372-wzwpyvll	113	9	had	have	VBD
cord-000372-wzwpyvll	113	10	no	no	DT
cord-000372-wzwpyvll	113	11	effect	effect	NN
cord-000372-wzwpyvll	113	12	on	on	IN
cord-000372-wzwpyvll	113	13	these	these	DT
cord-000372-wzwpyvll	113	14	proteases	protease	NNS
cord-000372-wzwpyvll	113	15	,	,	,
cord-000372-wzwpyvll	113	16	while	while	IN
cord-000372-wzwpyvll	113	17	L	L	NNP
cord-000372-wzwpyvll	113	18	pro	pro	JJ
cord-000372-wzwpyvll	113	19	activity	activity	NN
cord-000372-wzwpyvll	113	20	was	be	VBD
cord-000372-wzwpyvll	113	21	inhibited	inhibit	VBN
cord-000372-wzwpyvll	113	22	not	not	RB
cord-000372-wzwpyvll	113	23	only	only	RB
cord-000372-wzwpyvll	113	24	by	by	IN
cord-000372-wzwpyvll	113	25	sulphydrylactive	sulphydrylactive	JJ
cord-000372-wzwpyvll	113	26	compounds	compound	NNS
cord-000372-wzwpyvll	113	27	but	but	CC
cord-000372-wzwpyvll	113	28	also	also	RB
cord-000372-wzwpyvll	113	29	by	by	IN
cord-000372-wzwpyvll	113	30	E64	E64	NNP
cord-000372-wzwpyvll	113	31	[	[	-LRB-
cord-000372-wzwpyvll	113	32	56	56	CD
cord-000372-wzwpyvll	113	33	,	,	,
cord-000372-wzwpyvll	113	34	57	57	CD
cord-000372-wzwpyvll	113	35	]	]	-RRB-
cord-000372-wzwpyvll	113	36	.	.	.
cord-000372-wzwpyvll	114	1	These	these	DT
cord-000372-wzwpyvll	114	2	findings	finding	NNS
cord-000372-wzwpyvll	114	3	together	together	RB
cord-000372-wzwpyvll	114	4	with	with	IN
cord-000372-wzwpyvll	114	5	structural	structural	JJ
cord-000372-wzwpyvll	114	6	observations	observation	NNS
cord-000372-wzwpyvll	114	7	imply	imply	VBP
cord-000372-wzwpyvll	114	8	that	that	IN
cord-000372-wzwpyvll	114	9	L	l	NN
cord-000372-wzwpyvll	114	10	pro	pro	FW
cord-000372-wzwpyvll	114	11	belongs	belong	VBZ
cord-000372-wzwpyvll	114	12	to	to	IN
cord-000372-wzwpyvll	114	13	the	the	DT
cord-000372-wzwpyvll	114	14	class	class	NN
cord-000372-wzwpyvll	114	15	of	of	IN
cord-000372-wzwpyvll	114	16	papain	papain	NN
cord-000372-wzwpyvll	114	17	-	-	HYPH
cord-000372-wzwpyvll	114	18	like	like	JJ
cord-000372-wzwpyvll	114	19	cysteine	cysteine	NN
cord-000372-wzwpyvll	114	20	proteinases	proteinase	NNS
cord-000372-wzwpyvll	114	21	[	[	-LRB-
cord-000372-wzwpyvll	114	22	43	43	CD
cord-000372-wzwpyvll	114	23	,	,	,
cord-000372-wzwpyvll	114	24	[	[	-LRB-
cord-000372-wzwpyvll	114	25	58	58	CD
cord-000372-wzwpyvll	114	26	]	]	-RRB-
cord-000372-wzwpyvll	115	1	[	[	-LRB-
cord-000372-wzwpyvll	115	2	59	59	CD
cord-000372-wzwpyvll	115	3	]	]	-RRB-
cord-000372-wzwpyvll	115	4	[	[	-LRB-
cord-000372-wzwpyvll	115	5	60	60	CD
cord-000372-wzwpyvll	115	6	]	]	-RRB-
cord-000372-wzwpyvll	115	7	.	.	.
cord-000372-wzwpyvll	116	1	Comparison	comparison	NN
cord-000372-wzwpyvll	116	2	of	of	IN
cord-000372-wzwpyvll	116	3	the	the	DT
cord-000372-wzwpyvll	116	4	structure	structure	NN
cord-000372-wzwpyvll	116	5	of	of	IN
cord-000372-wzwpyvll	116	6	picornavirus	picornavirus	NN
cord-000372-wzwpyvll	116	7	proteases	protease	NNS
cord-000372-wzwpyvll	116	8	with	with	IN
cord-000372-wzwpyvll	116	9	prototypes	prototype	NNS
cord-000372-wzwpyvll	116	10	of	of	IN
cord-000372-wzwpyvll	116	11	cellular	cellular	JJ
cord-000372-wzwpyvll	116	12	ones	one	NNS
cord-000372-wzwpyvll	116	13	revealed	reveal	VBD
cord-000372-wzwpyvll	116	14	that	that	IN
cord-000372-wzwpyvll	116	15	both	both	DT
cord-000372-wzwpyvll	116	16	2A	2a	CD
cord-000372-wzwpyvll	116	17	pro	pro	NNP
cord-000372-wzwpyvll	116	18	and	and	CC
cord-000372-wzwpyvll	116	19	3C	3C	NNP
cord-000372-wzwpyvll	116	20	pro	pro	NNP
cord-000372-wzwpyvll	116	21	are	be	VBP
cord-000372-wzwpyvll	116	22	similar	similar	JJ
cord-000372-wzwpyvll	116	23	in	in	IN
cord-000372-wzwpyvll	116	24	structure	structure	NN
cord-000372-wzwpyvll	116	25	to	to	IN
cord-000372-wzwpyvll	116	26	the	the	DT
cord-000372-wzwpyvll	116	27	chymotrypsin	chymotrypsin	NNP
cord-000372-wzwpyvll	116	28	like	like	IN
cord-000372-wzwpyvll	116	29	group	group	NN
cord-000372-wzwpyvll	116	30	[	[	-LRB-
cord-000372-wzwpyvll	116	31	61	61	CD
cord-000372-wzwpyvll	116	32	]	]	-RRB-
cord-000372-wzwpyvll	117	1	[	[	-LRB-
cord-000372-wzwpyvll	117	2	62	62	CD
cord-000372-wzwpyvll	117	3	]	]	-RRB-
cord-000372-wzwpyvll	117	4	[	[	-LRB-
cord-000372-wzwpyvll	117	5	63	63	CD
cord-000372-wzwpyvll	117	6	]	]	-RRB-
cord-000372-wzwpyvll	117	7	.	.	.
cord-000372-wzwpyvll	118	1	Picornavirus	Picornavirus	NNP
cord-000372-wzwpyvll	118	2	3C	3c	NN
cord-000372-wzwpyvll	118	3	pro	pro	NNP
cord-000372-wzwpyvll	118	4	reflects	reflect	VBZ
cord-000372-wzwpyvll	118	5	similarities	similarity	NNS
cord-000372-wzwpyvll	118	6	to	to	IN
cord-000372-wzwpyvll	118	7	the	the	DT
cord-000372-wzwpyvll	118	8	staphylococcus	staphylococcus	NN
cord-000372-wzwpyvll	118	9	aureus	aureus	NN
cord-000372-wzwpyvll	118	10	proteinase	proteinase	NN
cord-000372-wzwpyvll	118	11	,	,	,
cord-000372-wzwpyvll	118	12	whereas	whereas	IN
cord-000372-wzwpyvll	118	13	2A	2a	CD
cord-000372-wzwpyvll	118	14	pro	pro	NNP
cord-000372-wzwpyvll	118	15	is	be	VBZ
cord-000372-wzwpyvll	118	16	more	more	RBR
cord-000372-wzwpyvll	118	17	akin	akin	JJ
cord-000372-wzwpyvll	118	18	to	to	IN
cord-000372-wzwpyvll	118	19	streptomyces	streptomyces	NNP
cord-000372-wzwpyvll	118	20	griseus	griseus	NN
cord-000372-wzwpyvll	118	21	proteinase	proteinase	NN
cord-000372-wzwpyvll	118	22	A.	a.	NN
cord-000372-wzwpyvll	118	23	PV	PV	NNP
cord-000372-wzwpyvll	118	24	2A	2a	CD
cord-000372-wzwpyvll	119	1	pro	pro	NNP
cord-000372-wzwpyvll	119	2	is	be	VBZ
cord-000372-wzwpyvll	119	3	a	a	DT
cord-000372-wzwpyvll	119	4	protein	protein	NN
cord-000372-wzwpyvll	119	5	composed	compose	VBN
cord-000372-wzwpyvll	119	6	of	of	IN
cord-000372-wzwpyvll	119	7	149	149	CD
cord-000372-wzwpyvll	119	8	amino	amino	JJ
cord-000372-wzwpyvll	119	9	acids	acid	NNS
cord-000372-wzwpyvll	119	10	that	that	WDT
cord-000372-wzwpyvll	119	11	belongs	belong	VBZ
cord-000372-wzwpyvll	119	12	to	to	IN
cord-000372-wzwpyvll	119	13	the	the	DT
cord-000372-wzwpyvll	119	14	cysteine	cysteine	NN
cord-000372-wzwpyvll	119	15	protease	protease	NN
cord-000372-wzwpyvll	119	16	group	group	NN
cord-000372-wzwpyvll	119	17	[	[	-LRB-
cord-000372-wzwpyvll	119	18	54	54	CD
cord-000372-wzwpyvll	119	19	]	]	-RRB-
cord-000372-wzwpyvll	119	20	.	.	.
cord-000372-wzwpyvll	120	1	PV	PV	NNP
cord-000372-wzwpyvll	120	2	2A	2a	CD
cord-000372-wzwpyvll	120	3	pro	pro	NNP
cord-000372-wzwpyvll	120	4	is	be	VBZ
cord-000372-wzwpyvll	120	5	autocatalytically	autocatalytically	RB
cord-000372-wzwpyvll	120	6	processed	process	VBN
cord-000372-wzwpyvll	120	7	at	at	IN
cord-000372-wzwpyvll	120	8	its	-PRON-	PRP$
cord-000372-wzwpyvll	120	9	amino	amino	NN
cord-000372-wzwpyvll	120	10	terminus	terminus	NN
cord-000372-wzwpyvll	120	11	between	between	IN
cord-000372-wzwpyvll	120	12	the	the	DT
cord-000372-wzwpyvll	120	13	capsid	capsid	JJ
cord-000372-wzwpyvll	120	14	protein	protein	NN
cord-000372-wzwpyvll	120	15	VP1	vp1	NN
cord-000372-wzwpyvll	120	16	and	and	CC
cord-000372-wzwpyvll	120	17	2A	2a	CD
cord-000372-wzwpyvll	120	18	[	[	-LRB-
cord-000372-wzwpyvll	120	19	64	64	CD
cord-000372-wzwpyvll	120	20	]	]	-RRB-
cord-000372-wzwpyvll	120	21	(	(	-LRB-
cord-000372-wzwpyvll	120	22	see	see	VB
cord-000372-wzwpyvll	120	23	Figure	figure	NN
cord-000372-wzwpyvll	120	24	1	1	CD
cord-000372-wzwpyvll	120	25	(	(	-LRB-
cord-000372-wzwpyvll	120	26	b	b	NN
cord-000372-wzwpyvll	120	27	)	)	-RRB-
cord-000372-wzwpyvll	120	28	)	)	-RRB-
cord-000372-wzwpyvll	120	29	.	.	.
cord-000372-wzwpyvll	121	1	The	the	DT
cord-000372-wzwpyvll	121	2	determinants	determinant	NNS
cord-000372-wzwpyvll	121	3	of	of	IN
cord-000372-wzwpyvll	121	4	substrate	substrate	JJ
cord-000372-wzwpyvll	121	5	specificity	specificity	NN
cord-000372-wzwpyvll	121	6	of	of	IN
cord-000372-wzwpyvll	121	7	picornaviral	picornaviral	NNP
cord-000372-wzwpyvll	121	8	PV	PV	NNP
cord-000372-wzwpyvll	121	9	2A	2a	CD
cord-000372-wzwpyvll	121	10	pro	pro	NNP
cord-000372-wzwpyvll	121	11	have	have	VBP
cord-000372-wzwpyvll	121	12	been	be	VBN
cord-000372-wzwpyvll	121	13	investigated	investigate	VBN
cord-000372-wzwpyvll	121	14	in	in	IN
cord-000372-wzwpyvll	121	15	detail	detail	NN
cord-000372-wzwpyvll	121	16	by	by	IN
cord-000372-wzwpyvll	121	17	identification	identification	NN
cord-000372-wzwpyvll	121	18	of	of	IN
cord-000372-wzwpyvll	121	19	cleavage	cleavage	NN
cord-000372-wzwpyvll	121	20	sites	site	NNS
cord-000372-wzwpyvll	121	21	by	by	IN
cord-000372-wzwpyvll	121	22	N	n	CD
cord-000372-wzwpyvll	121	23	-	-	HYPH
cord-000372-wzwpyvll	121	24	terminal	terminal	NN
cord-000372-wzwpyvll	121	25	Edman	Edman	NNP
cord-000372-wzwpyvll	121	26	degradation	degradation	NN
cord-000372-wzwpyvll	121	27	,	,	,
cord-000372-wzwpyvll	121	28	mutational	mutational	JJ
cord-000372-wzwpyvll	121	29	analysis	analysis	NN
cord-000372-wzwpyvll	121	30	and	and	CC
cord-000372-wzwpyvll	121	31	using	use	VBG
cord-000372-wzwpyvll	121	32	synthetic	synthetic	JJ
cord-000372-wzwpyvll	121	33	peptides	peptide	NNS
cord-000372-wzwpyvll	121	34	as	as	IN
cord-000372-wzwpyvll	121	35	substrates	substrate	NNS
cord-000372-wzwpyvll	121	36	[	[	-LRB-
cord-000372-wzwpyvll	121	37	34	34	CD
cord-000372-wzwpyvll	121	38	,	,	,
cord-000372-wzwpyvll	121	39	[	[	-LRB-
cord-000372-wzwpyvll	121	40	65	65	CD
cord-000372-wzwpyvll	121	41	]	]	-RRB-
cord-000372-wzwpyvll	122	1	[	[	-LRB-
cord-000372-wzwpyvll	122	2	66	66	CD
cord-000372-wzwpyvll	122	3	]	]	-RRB-
cord-000372-wzwpyvll	123	1	[	[	-LRB-
cord-000372-wzwpyvll	123	2	67	67	CD
cord-000372-wzwpyvll	123	3	]	]	-RRB-
cord-000372-wzwpyvll	123	4	.	.	.
cord-000372-wzwpyvll	124	1	PV	PV	NNP
cord-000372-wzwpyvll	124	2	2A	2a	CD
cord-000372-wzwpyvll	124	3	pro	pro	NNP
cord-000372-wzwpyvll	124	4	can	can	MD
cord-000372-wzwpyvll	124	5	recognize	recognize	VB
cord-000372-wzwpyvll	124	6	a	a	DT
cord-000372-wzwpyvll	124	7	wide	wide	JJ
cord-000372-wzwpyvll	124	8	variety	variety	NN
cord-000372-wzwpyvll	124	9	of	of	IN
cord-000372-wzwpyvll	124	10	amino	amino	NN
cord-000372-wzwpyvll	124	11	acid	acid	NN
cord-000372-wzwpyvll	124	12	residues	residue	NNS
cord-000372-wzwpyvll	124	13	at	at	IN
cord-000372-wzwpyvll	124	14	the	the	DT
cord-000372-wzwpyvll	124	15	P1	P1	NNP
cord-000372-wzwpyvll	124	16	position	position	NN
cord-000372-wzwpyvll	124	17	.	.	.
cord-000372-wzwpyvll	125	1	The	the	DT
cord-000372-wzwpyvll	125	2	determinants	determinant	NNS
cord-000372-wzwpyvll	125	3	of	of	IN
cord-000372-wzwpyvll	125	4	substrate	substrate	JJ
cord-000372-wzwpyvll	125	5	specificity	specificity	NN
cord-000372-wzwpyvll	125	6	for	for	IN
cord-000372-wzwpyvll	125	7	PV	pv	NN
cord-000372-wzwpyvll	125	8	2A	2a	CD
cord-000372-wzwpyvll	125	9	pro	pro	JJ
cord-000372-wzwpyvll	125	10	lie	lie	NN
cord-000372-wzwpyvll	125	11	at	at	IN
cord-000372-wzwpyvll	125	12	positions	position	NNS
cord-000372-wzwpyvll	125	13	P4	P4	NNP
cord-000372-wzwpyvll	125	14	,	,	,
cord-000372-wzwpyvll	125	15	P2	P2	NNP
cord-000372-wzwpyvll	125	16	,	,	,
cord-000372-wzwpyvll	125	17	P1	P1	NNP
cord-000372-wzwpyvll	125	18	,	,	,
cord-000372-wzwpyvll	125	19	and	and	CC
cord-000372-wzwpyvll	125	20	P2	P2	NNP
cord-000372-wzwpyvll	125	21	,	,	,
cord-000372-wzwpyvll	125	22	which	which	WDT
cord-000372-wzwpyvll	125	23	are	be	VBP
cord-000372-wzwpyvll	125	24	preferentially	preferentially	RB
cord-000372-wzwpyvll	125	25	occupied	occupy	VBN
cord-000372-wzwpyvll	125	26	with	with	IN
cord-000372-wzwpyvll	125	27	Ile	Ile	NNP
cord-000372-wzwpyvll	125	28	/	/	SYM
cord-000372-wzwpyvll	125	29	Leu	Leu	NNP
cord-000372-wzwpyvll	125	30	,	,	,
cord-000372-wzwpyvll	125	31	Thr	Thr	NNP
cord-000372-wzwpyvll	125	32	/	/	SYM
cord-000372-wzwpyvll	125	33	Ser	Ser	NNP
cord-000372-wzwpyvll	125	34	,	,	,
cord-000372-wzwpyvll	125	35	Gly	Gly	NNP
cord-000372-wzwpyvll	125	36	,	,	,
cord-000372-wzwpyvll	125	37	and	and	CC
cord-000372-wzwpyvll	125	38	Pro	Pro	NNP
cord-000372-wzwpyvll	125	39	,	,	,
cord-000372-wzwpyvll	125	40	respectively	respectively	RB
cord-000372-wzwpyvll	125	41	.	.	.
cord-000372-wzwpyvll	126	1	Moreover	moreover	RB
cord-000372-wzwpyvll	126	2	,	,	,
cord-000372-wzwpyvll	126	3	the	the	DT
cord-000372-wzwpyvll	126	4	determinants	determinant	NNS
cord-000372-wzwpyvll	126	5	of	of	IN
cord-000372-wzwpyvll	126	6	substrate	substrate	JJ
cord-000372-wzwpyvll	126	7	specificity	specificity	NN
cord-000372-wzwpyvll	126	8	of	of	IN
cord-000372-wzwpyvll	126	9	HRV	HRV	NNP
cord-000372-wzwpyvll	126	10	and	and	CC
cord-000372-wzwpyvll	126	11	coxsackievirus	coxsackievirus	NNP
cord-000372-wzwpyvll	126	12	2A	2A	NNP
cord-000372-wzwpyvll	126	13	pro	pro	NNP
cord-000372-wzwpyvll	126	14	are	be	VBP
cord-000372-wzwpyvll	126	15	very	very	RB
cord-000372-wzwpyvll	126	16	similar	similar	JJ
cord-000372-wzwpyvll	126	17	to	to	IN
cord-000372-wzwpyvll	126	18	those	those	DT
cord-000372-wzwpyvll	126	19	found	find	VBN
cord-000372-wzwpyvll	126	20	for	for	IN
cord-000372-wzwpyvll	126	21	PV	PV	NNP
cord-000372-wzwpyvll	126	22	2A	2a	CD
cord-000372-wzwpyvll	126	23	pro	pro	JJ
cord-000372-wzwpyvll	126	24	[	[	-LRB-
cord-000372-wzwpyvll	126	25	65	65	CD
cord-000372-wzwpyvll	126	26	]	]	-RRB-
cord-000372-wzwpyvll	127	1	[	[	-LRB-
cord-000372-wzwpyvll	127	2	66	66	CD
cord-000372-wzwpyvll	127	3	]	]	-RRB-
cord-000372-wzwpyvll	127	4	[	[	-LRB-
cord-000372-wzwpyvll	127	5	67	67	CD
cord-000372-wzwpyvll	127	6	]	]	-RRB-
cord-000372-wzwpyvll	127	7	.	.	.
cord-000372-wzwpyvll	128	1	The	the	DT
cord-000372-wzwpyvll	128	2	yeast	yeast	NN
cord-000372-wzwpyvll	128	3	two	two	CD
cord-000372-wzwpyvll	128	4	-	-	HYPH
cord-000372-wzwpyvll	128	5	hybrid	hybrid	NN
cord-000372-wzwpyvll	128	6	system	system	NN
cord-000372-wzwpyvll	128	7	has	have	VBZ
cord-000372-wzwpyvll	128	8	been	be	VBN
cord-000372-wzwpyvll	128	9	used	use	VBN
cord-000372-wzwpyvll	128	10	to	to	TO
cord-000372-wzwpyvll	128	11	identify	identify	VB
cord-000372-wzwpyvll	128	12	the	the	DT
cord-000372-wzwpyvll	128	13	substrate	substrate	NN
cord-000372-wzwpyvll	128	14	sequence	sequence	NN
cord-000372-wzwpyvll	128	15	interacting	interact	VBG
cord-000372-wzwpyvll	128	16	with	with	IN
cord-000372-wzwpyvll	128	17	PV	PV	NNP
cord-000372-wzwpyvll	128	18	2A	2a	CD
cord-000372-wzwpyvll	128	19	pro	pro	JJ
cord-000372-wzwpyvll	128	20	.	.	.
cord-000372-wzwpyvll	129	1	All	all	PDT
cord-000372-wzwpyvll	129	2	the	the	DT
cord-000372-wzwpyvll	129	3	sequences	sequence	NNS
cord-000372-wzwpyvll	129	4	identified	identify	VBN
cord-000372-wzwpyvll	129	5	contain	contain	VBP
cord-000372-wzwpyvll	129	6	the	the	DT
cord-000372-wzwpyvll	129	7	Leu	Leu	NNP
cord-000372-wzwpyvll	129	8	-	-	HYPH
cord-000372-wzwpyvll	129	9	X	X	NNP
cord-000372-wzwpyvll	129	10	-	-	HYPH
cord-000372-wzwpyvll	129	11	Thr	Thr	NNP
cord-000372-wzwpyvll	129	12	-	-	HYPH
cord-000372-wzwpyvll	129	13	Z	z	NN
cord-000372-wzwpyvll	129	14	motif	motif	NN
cord-000372-wzwpyvll	129	15	(	(	-LRB-
cord-000372-wzwpyvll	129	16	X	x	VB
cord-000372-wzwpyvll	129	17	for	for	IN
cord-000372-wzwpyvll	129	18	any	any	DT
cord-000372-wzwpyvll	129	19	amino	amino	NN
cord-000372-wzwpyvll	129	20	acid	acid	NN
cord-000372-wzwpyvll	129	21	;	;	:
cord-000372-wzwpyvll	129	22	Z	z	NN
cord-000372-wzwpyvll	129	23	for	for	IN
cord-000372-wzwpyvll	129	24	a	a	DT
cord-000372-wzwpyvll	129	25	hydrophobic	hydrophobic	JJ
cord-000372-wzwpyvll	129	26	residue	residue	NN
cord-000372-wzwpyvll	129	27	)	)	-RRB-
cord-000372-wzwpyvll	129	28	in	in	IN
cord-000372-wzwpyvll	129	29	positions	position	NNS
cord-000372-wzwpyvll	129	30	from	from	IN
cord-000372-wzwpyvll	129	31	P4	P4	NNP
cord-000372-wzwpyvll	129	32	to	to	IN
cord-000372-wzwpyvll	129	33	P1	P1	NNP
cord-000372-wzwpyvll	129	34	suggesting	suggest	VBG
cord-000372-wzwpyvll	129	35	the	the	DT
cord-000372-wzwpyvll	129	36	presence	presence	NN
cord-000372-wzwpyvll	129	37	of	of	IN
cord-000372-wzwpyvll	129	38	a	a	DT
cord-000372-wzwpyvll	129	39	common	common	JJ
cord-000372-wzwpyvll	129	40	interacting	interact	VBG
cord-000372-wzwpyvll	129	41	site	site	NN
cord-000372-wzwpyvll	129	42	on	on	IN
cord-000372-wzwpyvll	129	43	PV	PV	NNP
cord-000372-wzwpyvll	129	44	2A	2a	CD
cord-000372-wzwpyvll	129	45	pro	pro	JJ
cord-000372-wzwpyvll	129	46	substrates	substrate	NNS
cord-000372-wzwpyvll	129	47	[	[	-LRB-
cord-000372-wzwpyvll	129	48	68	68	CD
cord-000372-wzwpyvll	129	49	]	]	-RRB-
cord-000372-wzwpyvll	129	50	.	.	.
cord-000372-wzwpyvll	130	1	Several	several	JJ
cord-000372-wzwpyvll	130	2	2A	2a	CD
cord-000372-wzwpyvll	130	3	pro	pro	JJ
cord-000372-wzwpyvll	130	4	variants	variant	NNS
cord-000372-wzwpyvll	130	5	have	have	VBP
cord-000372-wzwpyvll	130	6	been	be	VBN
cord-000372-wzwpyvll	130	7	generated	generate	VBN
cord-000372-wzwpyvll	130	8	in	in	IN
cord-000372-wzwpyvll	130	9	the	the	DT
cord-000372-wzwpyvll	130	10	entire	entire	JJ
cord-000372-wzwpyvll	130	11	PV	pv	NN
cord-000372-wzwpyvll	130	12	genome	genome	NN
cord-000372-wzwpyvll	130	13	or	or	CC
cord-000372-wzwpyvll	130	14	in	in	IN
cord-000372-wzwpyvll	130	15	the	the	DT
cord-000372-wzwpyvll	130	16	isolated	isolate	VBN
cord-000372-wzwpyvll	130	17	2A	2a	CD
cord-000372-wzwpyvll	130	18	gene	gene	NN
cord-000372-wzwpyvll	130	19	.	.	.
cord-000372-wzwpyvll	131	1	Generation	generation	NN
cord-000372-wzwpyvll	131	2	of	of	IN
cord-000372-wzwpyvll	131	3	PV	PV	NNP
cord-000372-wzwpyvll	131	4	2A	2a	CD
cord-000372-wzwpyvll	131	5	pro	pro	JJ
cord-000372-wzwpyvll	131	6	mutants	mutant	NNS
cord-000372-wzwpyvll	131	7	was	be	VBD
cord-000372-wzwpyvll	131	8	initially	initially	RB
cord-000372-wzwpyvll	131	9	used	use	VBN
cord-000372-wzwpyvll	131	10	to	to	TO
cord-000372-wzwpyvll	131	11	identify	identify	VB
cord-000372-wzwpyvll	131	12	the	the	DT
cord-000372-wzwpyvll	131	13	Cys	Cys	NNP
cord-000372-wzwpyvll	131	14	106	106	CD
cord-000372-wzwpyvll	131	15	,	,	,
cord-000372-wzwpyvll	131	16	His	-PRON-	PRP$
cord-000372-wzwpyvll	131	17	18	18	CD
cord-000372-wzwpyvll	131	18	,	,	,
cord-000372-wzwpyvll	131	19	and	and	CC
cord-000372-wzwpyvll	131	20	Asp	Asp	NNP
cord-000372-wzwpyvll	131	21	35	35	CD
cord-000372-wzwpyvll	131	22	as	as	IN
cord-000372-wzwpyvll	131	23	the	the	DT
cord-000372-wzwpyvll	131	24	residues	residue	NNS
cord-000372-wzwpyvll	131	25	that	that	WDT
cord-000372-wzwpyvll	131	26	form	form	VBP
cord-000372-wzwpyvll	131	27	part	part	NN
cord-000372-wzwpyvll	131	28	of	of	IN
cord-000372-wzwpyvll	131	29	the	the	DT
cord-000372-wzwpyvll	131	30	catalytic	catalytic	JJ
cord-000372-wzwpyvll	131	31	triad	triad	NN
cord-000372-wzwpyvll	131	32	of	of	IN
cord-000372-wzwpyvll	131	33	2A	2A	NNP
cord-000372-wzwpyvll	131	34	pro	pro	NNP
cord-000372-wzwpyvll	131	35	[	[	-LRB-
cord-000372-wzwpyvll	131	36	69	69	CD
cord-000372-wzwpyvll	131	37	,	,	,
cord-000372-wzwpyvll	131	38	70	70	CD
cord-000372-wzwpyvll	131	39	]	]	-RRB-
cord-000372-wzwpyvll	131	40	.	.	.
cord-000372-wzwpyvll	132	1	These	these	DT
cord-000372-wzwpyvll	132	2	data	datum	NNS
cord-000372-wzwpyvll	132	3	have	have	VBP
cord-000372-wzwpyvll	132	4	been	be	VBN
cord-000372-wzwpyvll	132	5	confirmed	confirm	VBN
cord-000372-wzwpyvll	132	6	in	in	IN
cord-000372-wzwpyvll	132	7	the	the	DT
cord-000372-wzwpyvll	132	8	structure	structure	NN
cord-000372-wzwpyvll	132	9	of	of	IN
cord-000372-wzwpyvll	132	10	HRV2	HRV2	NNP
cord-000372-wzwpyvll	132	11	2A	2a	CD
cord-000372-wzwpyvll	132	12	pro	pro	JJ
cord-000372-wzwpyvll	132	13	[	[	-LRB-
cord-000372-wzwpyvll	132	14	71	71	CD
cord-000372-wzwpyvll	132	15	]	]	-RRB-
cord-000372-wzwpyvll	132	16	.	.	.
cord-000372-wzwpyvll	133	1	The	the	DT
cord-000372-wzwpyvll	133	2	role	role	NN
cord-000372-wzwpyvll	133	3	of	of	IN
cord-000372-wzwpyvll	133	4	the	the	DT
cord-000372-wzwpyvll	133	5	conserved	conserve	VBN
cord-000372-wzwpyvll	133	6	Cys	Cys	NNP
cord-000372-wzwpyvll	133	7	and	and	CC
cord-000372-wzwpyvll	133	8	His	-PRON-	PRP$
cord-000372-wzwpyvll	133	9	residues	residue	NNS
cord-000372-wzwpyvll	133	10	in	in	IN
cord-000372-wzwpyvll	133	11	the	the	DT
cord-000372-wzwpyvll	133	12	structure	structure	NN
cord-000372-wzwpyvll	133	13	-	-	HYPH
cord-000372-wzwpyvll	133	14	function	function	NN
cord-000372-wzwpyvll	133	15	relationship	relationship	NN
cord-000372-wzwpyvll	133	16	has	have	VBZ
cord-000372-wzwpyvll	133	17	also	also	RB
cord-000372-wzwpyvll	133	18	been	be	VBN
cord-000372-wzwpyvll	133	19	studied	study	VBN
cord-000372-wzwpyvll	133	20	by	by	IN
cord-000372-wzwpyvll	133	21	mutagenesis	mutagenesis	NN
cord-000372-wzwpyvll	133	22	.	.	.
cord-000372-wzwpyvll	134	1	The	the	DT
cord-000372-wzwpyvll	134	2	residues	residue	NNS
cord-000372-wzwpyvll	134	3	Cys	Cys	NNP
cord-000372-wzwpyvll	134	4	55	55	CD
cord-000372-wzwpyvll	134	5	,	,	,
cord-000372-wzwpyvll	134	6	Cys	Cys	NNP
cord-000372-wzwpyvll	134	7	57	57	CD
cord-000372-wzwpyvll	134	8	,	,	,
cord-000372-wzwpyvll	134	9	Cys	Cys	NNP
cord-000372-wzwpyvll	134	10	115	115	CD
cord-000372-wzwpyvll	134	11	,	,	,
cord-000372-wzwpyvll	134	12	and	and	CC
cord-000372-wzwpyvll	134	13	His	-PRON-	PRP$
cord-000372-wzwpyvll	134	14	117	117	CD
cord-000372-wzwpyvll	134	15	play	play	VBP
cord-000372-wzwpyvll	134	16	a	a	DT
cord-000372-wzwpyvll	134	17	critical	critical	JJ
cord-000372-wzwpyvll	134	18	role	role	NN
cord-000372-wzwpyvll	134	19	in	in	IN
cord-000372-wzwpyvll	134	20	the	the	DT
cord-000372-wzwpyvll	134	21	cis	cis	NNP
cord-000372-wzwpyvll	134	22	and	and	CC
cord-000372-wzwpyvll	134	23	trans	trans	NNP
cord-000372-wzwpyvll	134	24	proteolytic	proteolytic	JJ
cord-000372-wzwpyvll	134	25	activity	activity	NN
cord-000372-wzwpyvll	134	26	by	by	IN
cord-000372-wzwpyvll	134	27	maintaining	maintain	VBG
cord-000372-wzwpyvll	134	28	2A	2a	CD
cord-000372-wzwpyvll	134	29	pro	pro	JJ
cord-000372-wzwpyvll	134	30	structure	structure	NN
cord-000372-wzwpyvll	134	31	[	[	-LRB-
cord-000372-wzwpyvll	134	32	72	72	CD
cord-000372-wzwpyvll	134	33	]	]	-RRB-
cord-000372-wzwpyvll	134	34	.	.	.
cord-000372-wzwpyvll	135	1	The	the	DT
cord-000372-wzwpyvll	135	2	structure	structure	NN
cord-000372-wzwpyvll	135	3	of	of	IN
cord-000372-wzwpyvll	135	4	HRV2	HRV2	NNP
cord-000372-wzwpyvll	135	5	2A	2a	CD
cord-000372-wzwpyvll	135	6	pro	pro	NNP
cord-000372-wzwpyvll	135	7	shows	show	VBZ
cord-000372-wzwpyvll	135	8	that	that	IN
cord-000372-wzwpyvll	135	9	the	the	DT
cord-000372-wzwpyvll	135	10	Zn	Zn	NNP
cord-000372-wzwpyvll	135	11	2	2	CD
cord-000372-wzwpyvll	135	12	+	+	CC
cord-000372-wzwpyvll	135	13	ion	ion	NN
cord-000372-wzwpyvll	135	14	is	be	VBZ
cord-000372-wzwpyvll	135	15	coordinated	coordinate	VBN
cord-000372-wzwpyvll	135	16	tetrahedrally	tetrahedrally	NN
cord-000372-wzwpyvll	135	17	by	by	IN
cord-000372-wzwpyvll	135	18	the	the	DT
cord-000372-wzwpyvll	135	19	side	side	NN
cord-000372-wzwpyvll	135	20	chains	chain	NNS
cord-000372-wzwpyvll	135	21	of	of	IN
cord-000372-wzwpyvll	135	22	these	these	DT
cord-000372-wzwpyvll	135	23	conserved	conserve	VBN
cord-000372-wzwpyvll	135	24	Cys	Cys	NNP
cord-000372-wzwpyvll	135	25	and	and	CC
cord-000372-wzwpyvll	135	26	His	-PRON-	PRP$
cord-000372-wzwpyvll	135	27	residues	residue	NNS
cord-000372-wzwpyvll	135	28	.	.	.
cord-000372-wzwpyvll	136	1	This	this	DT
cord-000372-wzwpyvll	136	2	Zn	Zn	NNP
cord-000372-wzwpyvll	136	3	2	2	CD
cord-000372-wzwpyvll	136	4	+	+	CC
cord-000372-wzwpyvll	136	5	ion	ion	NN
cord-000372-wzwpyvll	136	6	is	be	VBZ
cord-000372-wzwpyvll	136	7	tightly	tightly	RB
cord-000372-wzwpyvll	136	8	bound	bind	VBN
cord-000372-wzwpyvll	136	9	near	near	RB
cord-000372-wzwpyvll	136	10	to	to	IN
cord-000372-wzwpyvll	136	11	the	the	DT
cord-000372-wzwpyvll	136	12	C	C	NNP
cord-000372-wzwpyvll	136	13	-	-	HYPH
cord-000372-wzwpyvll	136	14	terminal	terminal	NN
cord-000372-wzwpyvll	136	15	domain	domain	NN
cord-000372-wzwpyvll	136	16	and	and	CC
cord-000372-wzwpyvll	136	17	may	may	MD
cord-000372-wzwpyvll	136	18	be	be	VB
cord-000372-wzwpyvll	136	19	important	important	JJ
cord-000372-wzwpyvll	136	20	for	for	IN
cord-000372-wzwpyvll	136	21	the	the	DT
cord-000372-wzwpyvll	136	22	stability	stability	NN
cord-000372-wzwpyvll	136	23	of	of	IN
cord-000372-wzwpyvll	136	24	the	the	DT
cord-000372-wzwpyvll	136	25	2A	2a	CD
cord-000372-wzwpyvll	136	26	pro	pro	JJ
cord-000372-wzwpyvll	136	27	[	[	-LRB-
cord-000372-wzwpyvll	136	28	71	71	CD
cord-000372-wzwpyvll	136	29	,	,	,
cord-000372-wzwpyvll	136	30	73	73	CD
cord-000372-wzwpyvll	136	31	,	,	,
cord-000372-wzwpyvll	136	32	74	74	CD
cord-000372-wzwpyvll	136	33	]	]	-RRB-
cord-000372-wzwpyvll	136	34	.	.	.
cord-000372-wzwpyvll	137	1	The	the	DT
cord-000372-wzwpyvll	137	2	yeast	yeast	NN
cord-000372-wzwpyvll	137	3	Saccharomyces	Saccharomyces	NNP
cord-000372-wzwpyvll	137	4	cerevisiae	cerevisiae	NNS
cord-000372-wzwpyvll	137	5	has	have	VBZ
cord-000372-wzwpyvll	137	6	been	be	VBN
cord-000372-wzwpyvll	137	7	used	use	VBN
cord-000372-wzwpyvll	137	8	as	as	IN
cord-000372-wzwpyvll	137	9	a	a	DT
cord-000372-wzwpyvll	137	10	system	system	NN
cord-000372-wzwpyvll	137	11	to	to	TO
cord-000372-wzwpyvll	137	12	obtain	obtain	VB
cord-000372-wzwpyvll	137	13	PV	PV	NNP
cord-000372-wzwpyvll	137	14	2A	2a	CD
cord-000372-wzwpyvll	137	15	pro	pro	JJ
cord-000372-wzwpyvll	137	16	variants	variant	NNS
cord-000372-wzwpyvll	137	17	[	[	-LRB-
cord-000372-wzwpyvll	137	18	75	75	CD
cord-000372-wzwpyvll	137	19	]	]	-RRB-
cord-000372-wzwpyvll	137	20	.	.	.
cord-000372-wzwpyvll	138	1	The	the	DT
cord-000372-wzwpyvll	138	2	fact	fact	NN
cord-000372-wzwpyvll	138	3	that	that	IN
cord-000372-wzwpyvll	138	4	this	this	DT
cord-000372-wzwpyvll	138	5	protease	protease	NN
cord-000372-wzwpyvll	138	6	is	be	VBZ
cord-000372-wzwpyvll	138	7	very	very	RB
cord-000372-wzwpyvll	138	8	toxic	toxic	JJ
cord-000372-wzwpyvll	138	9	for	for	IN
cord-000372-wzwpyvll	138	10	yeast	yeast	NN
cord-000372-wzwpyvll	138	11	has	have	VBZ
cord-000372-wzwpyvll	138	12	been	be	VBN
cord-000372-wzwpyvll	138	13	exploited	exploit	VBN
cord-000372-wzwpyvll	138	14	to	to	TO
cord-000372-wzwpyvll	138	15	generate	generate	VB
cord-000372-wzwpyvll	138	16	2A	2a	CD
cord-000372-wzwpyvll	138	17	pro	pro	JJ
cord-000372-wzwpyvll	138	18	variants	variant	NNS
cord-000372-wzwpyvll	138	19	devoid	devoid	JJ
cord-000372-wzwpyvll	138	20	of	of	IN
cord-000372-wzwpyvll	138	21	this	this	DT
cord-000372-wzwpyvll	138	22	cytotoxicity	cytotoxicity	NN
cord-000372-wzwpyvll	138	23	.	.	.
cord-000372-wzwpyvll	139	1	Using	use	VBG
cord-000372-wzwpyvll	139	2	this	this	DT
cord-000372-wzwpyvll	139	3	approach	approach	NN
cord-000372-wzwpyvll	139	4	,	,	,
cord-000372-wzwpyvll	139	5	several	several	JJ
cord-000372-wzwpyvll	139	6	PV	pv	NN
cord-000372-wzwpyvll	139	7	2A	2a	NN
cord-000372-wzwpyvll	139	8	pro	pro	JJ
cord-000372-wzwpyvll	139	9	unable	unable	JJ
cord-000372-wzwpyvll	139	10	to	to	TO
cord-000372-wzwpyvll	139	11	cleave	cleave	VB
cord-000372-wzwpyvll	139	12	eIF4	eIF4	NNP
cord-000372-wzwpyvll	139	13	G	g	NN
cord-000372-wzwpyvll	139	14	have	have	VBP
cord-000372-wzwpyvll	139	15	been	be	VBN
cord-000372-wzwpyvll	139	16	obtained	obtain	VBN
cord-000372-wzwpyvll	139	17	.	.	.
cord-000372-wzwpyvll	140	1	The	the	DT
cord-000372-wzwpyvll	140	2	characterization	characterization	NN
cord-000372-wzwpyvll	140	3	of	of	IN
cord-000372-wzwpyvll	140	4	these	these	DT
cord-000372-wzwpyvll	140	5	mutants	mutant	NNS
cord-000372-wzwpyvll	140	6	revealed	reveal	VBD
cord-000372-wzwpyvll	140	7	a	a	DT
cord-000372-wzwpyvll	140	8	region	region	NN
cord-000372-wzwpyvll	140	9	in	in	IN
cord-000372-wzwpyvll	140	10	2A	2a	CD
cord-000372-wzwpyvll	140	11	pro	pro	NNP
cord-000372-wzwpyvll	140	12	involved	involve	VBN
cord-000372-wzwpyvll	140	13	in	in	IN
cord-000372-wzwpyvll	140	14	the	the	DT
cord-000372-wzwpyvll	140	15	interaction	interaction	NN
cord-000372-wzwpyvll	140	16	with	with	IN
cord-000372-wzwpyvll	140	17	substrates	substrate	NNS
cord-000372-wzwpyvll	140	18	but	but	CC
cord-000372-wzwpyvll	140	19	none	none	NN
cord-000372-wzwpyvll	140	20	of	of	IN
cord-000372-wzwpyvll	140	21	the	the	DT
cord-000372-wzwpyvll	140	22	mutations	mutation	NNS
cord-000372-wzwpyvll	140	23	were	be	VBD
cord-000372-wzwpyvll	140	24	found	find	VBN
cord-000372-wzwpyvll	140	25	in	in	IN
cord-000372-wzwpyvll	140	26	the	the	DT
cord-000372-wzwpyvll	140	27	catalytic	catalytic	JJ
cord-000372-wzwpyvll	140	28	triad	triad	NN
cord-000372-wzwpyvll	140	29	.	.	.
cord-000372-wzwpyvll	141	1	A	a	DT
cord-000372-wzwpyvll	141	2	parallelism	parallelism	NN
cord-000372-wzwpyvll	141	3	has	have	VBZ
cord-000372-wzwpyvll	141	4	been	be	VBN
cord-000372-wzwpyvll	141	5	observed	observe	VBN
cord-000372-wzwpyvll	141	6	between	between	IN
cord-000372-wzwpyvll	141	7	the	the	DT
cord-000372-wzwpyvll	141	8	ability	ability	NN
cord-000372-wzwpyvll	141	9	of	of	IN
cord-000372-wzwpyvll	141	10	these	these	DT
cord-000372-wzwpyvll	141	11	PV	PV	NNP
cord-000372-wzwpyvll	141	12	2A	2a	NN
cord-000372-wzwpyvll	141	13	pro	pro	JJ
cord-000372-wzwpyvll	141	14	variants	variant	NNS
cord-000372-wzwpyvll	141	15	to	to	TO
cord-000372-wzwpyvll	141	16	block	block	VB
cord-000372-wzwpyvll	141	17	protein	protein	NN
cord-000372-wzwpyvll	141	18	synthesis	synthesis	NN
cord-000372-wzwpyvll	141	19	and	and	CC
cord-000372-wzwpyvll	141	20	to	to	TO
cord-000372-wzwpyvll	141	21	cleave	cleave	VB
cord-000372-wzwpyvll	141	22	eIF4	eIF4	NNP
cord-000372-wzwpyvll	141	23	G	G	NNP
cord-000372-wzwpyvll	141	24	[	[	-LRB-
cord-000372-wzwpyvll	141	25	76	76	CD
cord-000372-wzwpyvll	141	26	]	]	-RRB-
cord-000372-wzwpyvll	141	27	.	.	.
cord-000372-wzwpyvll	142	1	PV	pv	NN
cord-000372-wzwpyvll	142	2	mutants	mutant	NNS
cord-000372-wzwpyvll	142	3	in	in	IN
cord-000372-wzwpyvll	142	4	2A	2a	CD
cord-000372-wzwpyvll	142	5	gene	gene	NN
cord-000372-wzwpyvll	142	6	that	that	WDT
cord-000372-wzwpyvll	142	7	lack	lack	VBP
cord-000372-wzwpyvll	142	8	trans	trans	NNP
cord-000372-wzwpyvll	142	9	but	but	CC
cord-000372-wzwpyvll	142	10	not	not	RB
cord-000372-wzwpyvll	142	11	cis	cis	NNP
cord-000372-wzwpyvll	142	12	proteolytic	proteolytic	JJ
cord-000372-wzwpyvll	142	13	activity	activity	NN
cord-000372-wzwpyvll	142	14	have	have	VBP
cord-000372-wzwpyvll	142	15	been	be	VBN
cord-000372-wzwpyvll	142	16	also	also	RB
cord-000372-wzwpyvll	142	17	identified	identify	VBN
cord-000372-wzwpyvll	142	18	.	.	.
cord-000372-wzwpyvll	143	1	Normal	normal	JJ
cord-000372-wzwpyvll	143	2	Journal	Journal	NNP
cord-000372-wzwpyvll	143	3	of	of	IN
cord-000372-wzwpyvll	143	4	Biomedicine	Biomedicine	NNP
cord-000372-wzwpyvll	143	5	and	and	CC
cord-000372-wzwpyvll	143	6	Biotechnology	Biotechnology	NNP
cord-000372-wzwpyvll	143	7	processing	processing	NN
cord-000372-wzwpyvll	143	8	of	of	IN
cord-000372-wzwpyvll	143	9	the	the	DT
cord-000372-wzwpyvll	143	10	viral	viral	JJ
cord-000372-wzwpyvll	143	11	polyprotein	polyprotein	NN
cord-000372-wzwpyvll	143	12	is	be	VBZ
cord-000372-wzwpyvll	143	13	observed	observe	VBN
cord-000372-wzwpyvll	143	14	upon	upon	IN
cord-000372-wzwpyvll	143	15	infection	infection	NN
cord-000372-wzwpyvll	143	16	with	with	IN
cord-000372-wzwpyvll	143	17	these	these	DT
cord-000372-wzwpyvll	143	18	PV	PV	NNP
cord-000372-wzwpyvll	143	19	variants	variant	NNS
cord-000372-wzwpyvll	143	20	,	,	,
cord-000372-wzwpyvll	143	21	whereas	whereas	RB
cord-000372-wzwpyvll	143	22	eIF4	eif4	IN
cord-000372-wzwpyvll	143	23	G	G	NNP
cord-000372-wzwpyvll	143	24	remains	remain	VBZ
cord-000372-wzwpyvll	143	25	intact	intact	JJ
cord-000372-wzwpyvll	143	26	in	in	IN
cord-000372-wzwpyvll	143	27	these	these	DT
cord-000372-wzwpyvll	143	28	cells	cell	NNS
cord-000372-wzwpyvll	143	29	[	[	-LRB-
cord-000372-wzwpyvll	143	30	77	77	CD
cord-000372-wzwpyvll	143	31	]	]	-RRB-
cord-000372-wzwpyvll	143	32	.	.	.
cord-000372-wzwpyvll	144	1	Interestingly	interestingly	RB
cord-000372-wzwpyvll	144	2	,	,	,
cord-000372-wzwpyvll	144	3	RNA	RNA	NNP
cord-000372-wzwpyvll	144	4	replication	replication	NN
cord-000372-wzwpyvll	144	5	of	of	IN
cord-000372-wzwpyvll	144	6	those	those	DT
cord-000372-wzwpyvll	144	7	mutant	mutant	JJ
cord-000372-wzwpyvll	144	8	viruses	virus	NNS
cord-000372-wzwpyvll	144	9	is	be	VBZ
cord-000372-wzwpyvll	144	10	hampered	hamper	VBN
cord-000372-wzwpyvll	144	11	,	,	,
cord-000372-wzwpyvll	144	12	suggesting	suggest	VBG
cord-000372-wzwpyvll	144	13	that	that	IN
cord-000372-wzwpyvll	144	14	there	there	EX
cord-000372-wzwpyvll	144	15	is	be	VBZ
cord-000372-wzwpyvll	144	16	a	a	DT
cord-000372-wzwpyvll	144	17	correlation	correlation	NN
cord-000372-wzwpyvll	144	18	between	between	IN
cord-000372-wzwpyvll	144	19	PV	PV	NNP
cord-000372-wzwpyvll	144	20	RNA	RNA	NNP
cord-000372-wzwpyvll	144	21	replication	replication	NN
cord-000372-wzwpyvll	144	22	and	and	CC
cord-000372-wzwpyvll	144	23	the	the	DT
cord-000372-wzwpyvll	144	24	trans	trans	NNP
cord-000372-wzwpyvll	144	25	activity	activity	NN
cord-000372-wzwpyvll	144	26	of	of	IN
cord-000372-wzwpyvll	144	27	2A	2a	CD
cord-000372-wzwpyvll	144	28	pro	pro	NNP
cord-000372-wzwpyvll	144	29	.	.	.
cord-000372-wzwpyvll	145	1	It	-PRON-	PRP
cord-000372-wzwpyvll	145	2	is	be	VBZ
cord-000372-wzwpyvll	145	3	controversial	controversial	JJ
cord-000372-wzwpyvll	145	4	whether	whether	IN
cord-000372-wzwpyvll	145	5	PV	PV	NNP
cord-000372-wzwpyvll	145	6	2A	2a	CD
cord-000372-wzwpyvll	145	7	pro	pro	NNP
cord-000372-wzwpyvll	145	8	contributes	contribute	VBZ
cord-000372-wzwpyvll	145	9	directly	directly	RB
cord-000372-wzwpyvll	145	10	to	to	IN
cord-000372-wzwpyvll	145	11	viral	viral	JJ
cord-000372-wzwpyvll	145	12	replication	replication	NN
cord-000372-wzwpyvll	145	13	or	or	CC
cord-000372-wzwpyvll	145	14	not	not	RB
cord-000372-wzwpyvll	145	15	.	.	.
cord-000372-wzwpyvll	146	1	Although	although	IN
cord-000372-wzwpyvll	146	2	for	for	IN
cord-000372-wzwpyvll	146	3	many	many	JJ
cord-000372-wzwpyvll	146	4	years	year	NNS
cord-000372-wzwpyvll	146	5	it	-PRON-	PRP
cord-000372-wzwpyvll	146	6	was	be	VBD
cord-000372-wzwpyvll	146	7	thought	think	VBN
cord-000372-wzwpyvll	146	8	that	that	IN
cord-000372-wzwpyvll	146	9	PV	PV	NNP
cord-000372-wzwpyvll	146	10	2A	2a	NN
cord-000372-wzwpyvll	146	11	pro	pro	NNP
cord-000372-wzwpyvll	146	12	plays	play	VBZ
cord-000372-wzwpyvll	146	13	a	a	DT
cord-000372-wzwpyvll	146	14	direct	direct	JJ
cord-000372-wzwpyvll	146	15	role	role	NN
cord-000372-wzwpyvll	146	16	in	in	IN
cord-000372-wzwpyvll	146	17	PV	pv	NN
cord-000372-wzwpyvll	146	18	replication	replication	NN
cord-000372-wzwpyvll	146	19	,	,	,
cord-000372-wzwpyvll	146	20	more	more	JJR
cord-000372-wzwpyvll	146	21	recent	recent	JJ
cord-000372-wzwpyvll	146	22	studies	study	NNS
cord-000372-wzwpyvll	146	23	have	have	VBP
cord-000372-wzwpyvll	146	24	shown	show	VBN
cord-000372-wzwpyvll	146	25	that	that	IN
cord-000372-wzwpyvll	146	26	a	a	DT
cord-000372-wzwpyvll	146	27	full	full	JJ
cord-000372-wzwpyvll	146	28	-	-	HYPH
cord-000372-wzwpyvll	146	29	length	length	NN
cord-000372-wzwpyvll	146	30	dicistronic	dicistronic	JJ
cord-000372-wzwpyvll	146	31	PV	PV	NNP
cord-000372-wzwpyvll	146	32	construct	construct	VBP
cord-000372-wzwpyvll	146	33	lacking	lack	VBG
cord-000372-wzwpyvll	146	34	2A	2a	CD
cord-000372-wzwpyvll	146	35	pro	pro	JJ
cord-000372-wzwpyvll	146	36	is	be	VBZ
cord-000372-wzwpyvll	146	37	capable	capable	JJ
cord-000372-wzwpyvll	146	38	to	to	TO
cord-000372-wzwpyvll	146	39	give	give	VB
cord-000372-wzwpyvll	146	40	rise	rise	NN
cord-000372-wzwpyvll	146	41	to	to	IN
cord-000372-wzwpyvll	146	42	progeny	progeny	VB
cord-000372-wzwpyvll	146	43	viruses	virus	NNS
cord-000372-wzwpyvll	146	44	.	.	.
cord-000372-wzwpyvll	147	1	Moreover	moreover	RB
cord-000372-wzwpyvll	147	2	,	,	,
cord-000372-wzwpyvll	147	3	virus	virus	NN
cord-000372-wzwpyvll	147	4	yields	yield	NNS
cord-000372-wzwpyvll	147	5	of	of	IN
cord-000372-wzwpyvll	147	6	PV	pv	NN
cord-000372-wzwpyvll	147	7	variants	variant	NNS
cord-000372-wzwpyvll	147	8	lacking	lack	VBG
cord-000372-wzwpyvll	147	9	the	the	DT
cord-000372-wzwpyvll	147	10	P1	P1	NNP
cord-000372-wzwpyvll	147	11	coding	coding	NN
cord-000372-wzwpyvll	147	12	region	region	NN
cord-000372-wzwpyvll	147	13	is	be	VBZ
cord-000372-wzwpyvll	147	14	partially	partially	RB
cord-000372-wzwpyvll	147	15	restored	restore	VBN
cord-000372-wzwpyvll	147	16	when	when	WRB
cord-000372-wzwpyvll	147	17	P1	P1	NNP
cord-000372-wzwpyvll	147	18	is	be	VBZ
cord-000372-wzwpyvll	147	19	expressed	express	VBN
cord-000372-wzwpyvll	147	20	in	in	IN
cord-000372-wzwpyvll	147	21	trans	trans	NNP
cord-000372-wzwpyvll	147	22	,	,	,
cord-000372-wzwpyvll	147	23	suggesting	suggest	VBG
cord-000372-wzwpyvll	147	24	that	that	IN
cord-000372-wzwpyvll	147	25	cleavage	cleavage	NN
cord-000372-wzwpyvll	147	26	of	of	IN
cord-000372-wzwpyvll	147	27	the	the	DT
cord-000372-wzwpyvll	147	28	viral	viral	JJ
cord-000372-wzwpyvll	147	29	polyprotein	polyprotein	NN
cord-000372-wzwpyvll	147	30	by	by	IN
cord-000372-wzwpyvll	147	31	PV	PV	NNP
cord-000372-wzwpyvll	147	32	2A	2a	CD
cord-000372-wzwpyvll	147	33	pro	pro	NNP
cord-000372-wzwpyvll	147	34	is	be	VBZ
cord-000372-wzwpyvll	147	35	not	not	RB
cord-000372-wzwpyvll	147	36	essential	essential	JJ
cord-000372-wzwpyvll	147	37	for	for	IN
cord-000372-wzwpyvll	147	38	viral	viral	JJ
cord-000372-wzwpyvll	147	39	replication	replication	NN
cord-000372-wzwpyvll	147	40	.	.	.
cord-000372-wzwpyvll	148	1	[	[	-LRB-
cord-000372-wzwpyvll	148	2	78	78	CD
cord-000372-wzwpyvll	148	3	]	]	-RRB-
cord-000372-wzwpyvll	148	4	.	.	.
cord-000372-wzwpyvll	149	1	However	however	RB
cord-000372-wzwpyvll	149	2	,	,	,
cord-000372-wzwpyvll	149	3	it	-PRON-	PRP
cord-000372-wzwpyvll	149	4	is	be	VBZ
cord-000372-wzwpyvll	149	5	known	know	VBN
cord-000372-wzwpyvll	149	6	that	that	IN
cord-000372-wzwpyvll	149	7	2A	2a	CD
cord-000372-wzwpyvll	149	8	pro	pro	NNP
cord-000372-wzwpyvll	149	9	is	be	VBZ
cord-000372-wzwpyvll	149	10	important	important	JJ
cord-000372-wzwpyvll	149	11	for	for	IN
cord-000372-wzwpyvll	149	12	inducing	induce	VBG
cord-000372-wzwpyvll	149	13	the	the	DT
cord-000372-wzwpyvll	149	14	cytophatic	cytophatic	JJ
cord-000372-wzwpyvll	149	15	effect	effect	NN
cord-000372-wzwpyvll	149	16	and	and	CC
cord-000372-wzwpyvll	149	17	for	for	IN
cord-000372-wzwpyvll	149	18	avoiding	avoid	VBG
cord-000372-wzwpyvll	149	19	the	the	DT
cord-000372-wzwpyvll	149	20	inhibition	inhibition	NN
cord-000372-wzwpyvll	149	21	of	of	IN
cord-000372-wzwpyvll	149	22	PV	PV	NNP
cord-000372-wzwpyvll	149	23	replication	replication	NN
cord-000372-wzwpyvll	149	24	in	in	IN
cord-000372-wzwpyvll	149	25	interferon	interferon	NN
cord-000372-wzwpyvll	150	1	(	(	-LRB-
cord-000372-wzwpyvll	150	2	IFN	IFN	NNP
cord-000372-wzwpyvll	150	3	)	)	-RRB-
cord-000372-wzwpyvll	150	4	α	α	XX
cord-000372-wzwpyvll	150	5	treated	treat	VBD
cord-000372-wzwpyvll	150	6	cells	cell	NNS
cord-000372-wzwpyvll	150	7	[	[	-LRB-
cord-000372-wzwpyvll	150	8	79	79	CD
cord-000372-wzwpyvll	150	9	]	]	-RRB-
cord-000372-wzwpyvll	150	10	.	.	.
cord-000372-wzwpyvll	151	1	In	in	IN
cord-000372-wzwpyvll	151	2	agreement	agreement	NN
cord-000372-wzwpyvll	151	3	with	with	IN
cord-000372-wzwpyvll	151	4	the	the	DT
cord-000372-wzwpyvll	151	5	idea	idea	NN
cord-000372-wzwpyvll	151	6	that	that	IN
cord-000372-wzwpyvll	151	7	2A	2a	CD
cord-000372-wzwpyvll	151	8	pro	pro	NNP
cord-000372-wzwpyvll	151	9	participates	participate	VBZ
cord-000372-wzwpyvll	151	10	in	in	IN
cord-000372-wzwpyvll	151	11	viral	viral	JJ
cord-000372-wzwpyvll	151	12	RNA	RNA	NNP
cord-000372-wzwpyvll	151	13	replication	replication	NN
cord-000372-wzwpyvll	151	14	,	,	,
cord-000372-wzwpyvll	151	15	a	a	DT
cord-000372-wzwpyvll	151	16	fraction	fraction	NN
cord-000372-wzwpyvll	151	17	of	of	IN
cord-000372-wzwpyvll	151	18	this	this	DT
cord-000372-wzwpyvll	151	19	protease	protease	NN
cord-000372-wzwpyvll	151	20	localizes	localize	VBZ
cord-000372-wzwpyvll	151	21	in	in	IN
cord-000372-wzwpyvll	151	22	PV	pv	NN
cord-000372-wzwpyvll	151	23	replicative	replicative	JJ
cord-000372-wzwpyvll	151	24	foci	foci	NN
cord-000372-wzwpyvll	151	25	although	although	IN
cord-000372-wzwpyvll	151	26	the	the	DT
cord-000372-wzwpyvll	151	27	majority	majority	NN
cord-000372-wzwpyvll	151	28	of	of	IN
cord-000372-wzwpyvll	151	29	2A	2A	NNP
cord-000372-wzwpyvll	151	30	pro	pro	NNP
cord-000372-wzwpyvll	151	31	is	be	VBZ
cord-000372-wzwpyvll	151	32	associated	associate	VBN
cord-000372-wzwpyvll	151	33	with	with	IN
cord-000372-wzwpyvll	151	34	the	the	DT
cord-000372-wzwpyvll	151	35	matrix	matrix	NN
cord-000372-wzwpyvll	151	36	structure	structure	NN
cord-000372-wzwpyvll	151	37	in	in	IN
cord-000372-wzwpyvll	151	38	the	the	DT
cord-000372-wzwpyvll	151	39	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	151	40	of	of	IN
cord-000372-wzwpyvll	151	41	infected	infected	JJ
cord-000372-wzwpyvll	151	42	cells	cell	NNS
cord-000372-wzwpyvll	151	43	[	[	-LRB-
cord-000372-wzwpyvll	151	44	80	80	CD
cord-000372-wzwpyvll	151	45	]	]	-RRB-
cord-000372-wzwpyvll	151	46	.	.	.
cord-000372-wzwpyvll	152	1	However	however	RB
cord-000372-wzwpyvll	152	2	,	,	,
cord-000372-wzwpyvll	152	3	the	the	DT
cord-000372-wzwpyvll	152	4	presence	presence	NN
cord-000372-wzwpyvll	152	5	of	of	IN
cord-000372-wzwpyvll	152	6	2A	2a	CD
cord-000372-wzwpyvll	152	7	pro	pro	NNP
cord-000372-wzwpyvll	152	8	in	in	IN
cord-000372-wzwpyvll	152	9	the	the	DT
cord-000372-wzwpyvll	152	10	proximity	proximity	NN
cord-000372-wzwpyvll	152	11	of	of	IN
cord-000372-wzwpyvll	152	12	replication	replication	NN
cord-000372-wzwpyvll	152	13	complexes	complex	NNS
cord-000372-wzwpyvll	152	14	does	do	VBZ
cord-000372-wzwpyvll	152	15	not	not	RB
cord-000372-wzwpyvll	152	16	demonstrate	demonstrate	VB
cord-000372-wzwpyvll	152	17	that	that	IN
cord-000372-wzwpyvll	152	18	it	-PRON-	PRP
cord-000372-wzwpyvll	152	19	participates	participate	VBZ
cord-000372-wzwpyvll	152	20	directly	directly	RB
cord-000372-wzwpyvll	152	21	in	in	IN
cord-000372-wzwpyvll	152	22	the	the	DT
cord-000372-wzwpyvll	152	23	replication	replication	NN
cord-000372-wzwpyvll	152	24	process	process	NN
cord-000372-wzwpyvll	152	25	.	.	.
cord-000372-wzwpyvll	152	26	 	 	_SP
cord-000372-wzwpyvll	153	1	5.1	5.1	CD
cord-000372-wzwpyvll	153	2	.	.	.
cord-000372-wzwpyvll	154	1	Structure	structure	NN
cord-000372-wzwpyvll	154	2	and	and	CC
cord-000372-wzwpyvll	154	3	Functioning	Functioning	NNP
cord-000372-wzwpyvll	154	4	of	of	IN
cord-000372-wzwpyvll	154	5	eIF4G.	eif4g.	ADD
cord-000372-wzwpyvll	155	1	The	the	DT
cord-000372-wzwpyvll	155	2	process	process	NN
cord-000372-wzwpyvll	155	3	of	of	IN
cord-000372-wzwpyvll	155	4	translation	translation	NN
cord-000372-wzwpyvll	155	5	can	can	MD
cord-000372-wzwpyvll	155	6	be	be	VB
cord-000372-wzwpyvll	155	7	divided	divide	VBN
cord-000372-wzwpyvll	155	8	in	in	IN
cord-000372-wzwpyvll	155	9	different	different	JJ
cord-000372-wzwpyvll	155	10	steps	step	NNS
cord-000372-wzwpyvll	155	11	:	:	:
cord-000372-wzwpyvll	155	12	initiation	initiation	NN
cord-000372-wzwpyvll	155	13	,	,	,
cord-000372-wzwpyvll	155	14	elongation	elongation	NN
cord-000372-wzwpyvll	155	15	,	,	,
cord-000372-wzwpyvll	155	16	termination	termination	NN
cord-000372-wzwpyvll	155	17	and	and	CC
cord-000372-wzwpyvll	155	18	ribosome	ribosome	NN
cord-000372-wzwpyvll	155	19	recycling	recycling	NN
cord-000372-wzwpyvll	155	20	.	.	.
cord-000372-wzwpyvll	156	1	The	the	DT
cord-000372-wzwpyvll	156	2	synthesis	synthesis	NN
cord-000372-wzwpyvll	156	3	of	of	IN
cord-000372-wzwpyvll	156	4	cellular	cellular	JJ
cord-000372-wzwpyvll	156	5	proteins	protein	NNS
cord-000372-wzwpyvll	156	6	is	be	VBZ
cord-000372-wzwpyvll	156	7	highly	highly	RB
cord-000372-wzwpyvll	156	8	regulated	regulate	VBN
cord-000372-wzwpyvll	156	9	,	,	,
cord-000372-wzwpyvll	156	10	and	and	CC
cord-000372-wzwpyvll	156	11	in	in	IN
cord-000372-wzwpyvll	156	12	this	this	DT
cord-000372-wzwpyvll	156	13	sense	sense	NN
cord-000372-wzwpyvll	156	14	,	,	,
cord-000372-wzwpyvll	156	15	the	the	DT
cord-000372-wzwpyvll	156	16	most	most	RBS
cord-000372-wzwpyvll	156	17	precisely	precisely	RB
cord-000372-wzwpyvll	156	18	controlled	control	VBN
cord-000372-wzwpyvll	156	19	step	step	NN
cord-000372-wzwpyvll	156	20	is	be	VBZ
cord-000372-wzwpyvll	156	21	the	the	DT
cord-000372-wzwpyvll	156	22	initiation	initiation	NN
cord-000372-wzwpyvll	156	23	of	of	IN
cord-000372-wzwpyvll	156	24	translation	translation	NN
cord-000372-wzwpyvll	156	25	(	(	-LRB-
cord-000372-wzwpyvll	156	26	for	for	IN
cord-000372-wzwpyvll	156	27	a	a	DT
cord-000372-wzwpyvll	156	28	recent	recent	JJ
cord-000372-wzwpyvll	156	29	review	review	NN
cord-000372-wzwpyvll	156	30	,	,	,
cord-000372-wzwpyvll	156	31	see	see	VB
cord-000372-wzwpyvll	156	32	[	[	-LRB-
cord-000372-wzwpyvll	156	33	81	81	CD
cord-000372-wzwpyvll	156	34	,	,	,
cord-000372-wzwpyvll	156	35	82	82	CD
cord-000372-wzwpyvll	156	36	]	]	-RRB-
cord-000372-wzwpyvll	156	37	)	)	-RRB-
cord-000372-wzwpyvll	156	38	.	.	.
cord-000372-wzwpyvll	157	1	For	for	IN
cord-000372-wzwpyvll	157	2	most	most	JJS
cord-000372-wzwpyvll	157	3	eukaryotic	eukaryotic	JJ
cord-000372-wzwpyvll	157	4	mRNAs	mRNAs	NNPS
cord-000372-wzwpyvll	157	5	,	,	,
cord-000372-wzwpyvll	157	6	the	the	DT
cord-000372-wzwpyvll	157	7	initiation	initiation	NN
cord-000372-wzwpyvll	157	8	of	of	IN
cord-000372-wzwpyvll	157	9	translation	translation	NN
cord-000372-wzwpyvll	157	10	commences	commence	VBZ
cord-000372-wzwpyvll	157	11	with	with	IN
cord-000372-wzwpyvll	157	12	the	the	DT
cord-000372-wzwpyvll	157	13	recognition	recognition	NN
cord-000372-wzwpyvll	157	14	of	of	IN
cord-000372-wzwpyvll	157	15	the	the	DT
cord-000372-wzwpyvll	157	16	cap	cap	NN
cord-000372-wzwpyvll	157	17	structure	structure	NN
cord-000372-wzwpyvll	157	18	(	(	-LRB-
cord-000372-wzwpyvll	157	19	7	7	CD
cord-000372-wzwpyvll	157	20	mGpppN	mGpppN	NNS
cord-000372-wzwpyvll	157	21	)	)	-RRB-
cord-000372-wzwpyvll	157	22	and	and	CC
cord-000372-wzwpyvll	157	23	the	the	DT
cord-000372-wzwpyvll	157	24	poly(A	poly(a	JJ
cord-000372-wzwpyvll	157	25	)	)	-RRB-
cord-000372-wzwpyvll	157	26	tail	tail	NN
cord-000372-wzwpyvll	157	27	by	by	IN
cord-000372-wzwpyvll	157	28	the	the	DT
cord-000372-wzwpyvll	157	29	heterotrimeric	heterotrimeric	JJ
cord-000372-wzwpyvll	157	30	complex	complex	JJ
cord-000372-wzwpyvll	157	31	eIF4F	eif4f	CD
cord-000372-wzwpyvll	157	32	and	and	CC
cord-000372-wzwpyvll	157	33	the	the	DT
cord-000372-wzwpyvll	157	34	poly(A)-binding	poly(A)-binding	NNP
cord-000372-wzwpyvll	157	35	protein	protein	NN
cord-000372-wzwpyvll	157	36	(	(	-LRB-
cord-000372-wzwpyvll	157	37	PABP	PABP	NNP
cord-000372-wzwpyvll	157	38	)	)	-RRB-
cord-000372-wzwpyvll	157	39	,	,	,
cord-000372-wzwpyvll	157	40	respectively	respectively	RB
cord-000372-wzwpyvll	157	41	,	,	,
cord-000372-wzwpyvll	157	42	followed	follow	VBN
cord-000372-wzwpyvll	157	43	by	by	IN
cord-000372-wzwpyvll	157	44	the	the	DT
cord-000372-wzwpyvll	157	45	recruitment	recruitment	NN
cord-000372-wzwpyvll	157	46	of	of	IN
cord-000372-wzwpyvll	157	47	the	the	DT
cord-000372-wzwpyvll	157	48	43S	43s	JJ
cord-000372-wzwpyvll	157	49	preinitiation	preinitiation	NN
cord-000372-wzwpyvll	157	50	complex	complex	NN
cord-000372-wzwpyvll	157	51	containing	contain	VBG
cord-000372-wzwpyvll	157	52	the	the	DT
cord-000372-wzwpyvll	157	53	40S	40s	CD
cord-000372-wzwpyvll	157	54	ribosomal	ribosomal	JJ
cord-000372-wzwpyvll	157	55	subunit	subunit	NN
cord-000372-wzwpyvll	157	56	,	,	,
cord-000372-wzwpyvll	157	57	the	the	DT
cord-000372-wzwpyvll	157	58	ternary	ternary	JJ
cord-000372-wzwpyvll	157	59	complex	complex	NN
cord-000372-wzwpyvll	157	60	Met	Met	NNP
cord-000372-wzwpyvll	157	61	-	-	HYPH
cord-000372-wzwpyvll	157	62	tRNA	tRNA	NNP
cord-000372-wzwpyvll	157	63	Met	Met	NNP
cord-000372-wzwpyvll	157	64	i	i	PRP
cord-000372-wzwpyvll	157	65	-eIF2-GTP	-eif2-gtp	VBP
cord-000372-wzwpyvll	157	66	,	,	,
cord-000372-wzwpyvll	157	67	and	and	CC
cord-000372-wzwpyvll	157	68	the	the	DT
cord-000372-wzwpyvll	157	69	eukaryotic	eukaryotic	JJ
cord-000372-wzwpyvll	157	70	initiation	initiation	NN
cord-000372-wzwpyvll	157	71	factors	factor	NNS
cord-000372-wzwpyvll	157	72	(	(	-LRB-
cord-000372-wzwpyvll	157	73	eIFs	eIFs	NNP
cord-000372-wzwpyvll	157	74	)	)	-RRB-
cord-000372-wzwpyvll	157	75	,	,	,
cord-000372-wzwpyvll	157	76	1	1	CD
cord-000372-wzwpyvll	157	77	,	,	,
cord-000372-wzwpyvll	157	78	1A	1a	CD
cord-000372-wzwpyvll	157	79	,	,	,
cord-000372-wzwpyvll	157	80	3	3	CD
cord-000372-wzwpyvll	157	81	,	,	,
cord-000372-wzwpyvll	157	82	and	and	CC
cord-000372-wzwpyvll	157	83	5	5	CD
cord-000372-wzwpyvll	157	84	.	.	.
cord-000372-wzwpyvll	158	1	Then	then	RB
cord-000372-wzwpyvll	158	2	,	,	,
cord-000372-wzwpyvll	158	3	the	the	DT
cord-000372-wzwpyvll	158	4	preinitiation	preinitiation	NN
cord-000372-wzwpyvll	158	5	complex	complex	NN
cord-000372-wzwpyvll	158	6	scans	scan	VBZ
cord-000372-wzwpyvll	158	7	along	along	IN
cord-000372-wzwpyvll	158	8	the	the	DT
cord-000372-wzwpyvll	158	9	5	5	CD
cord-000372-wzwpyvll	158	10	untranslated	untranslated	JJ
cord-000372-wzwpyvll	158	11	region	region	NN
cord-000372-wzwpyvll	158	12	until	until	IN
cord-000372-wzwpyvll	158	13	an	an	DT
cord-000372-wzwpyvll	158	14	AUG	AUG	NNP
cord-000372-wzwpyvll	158	15	initiation	initiation	NN
cord-000372-wzwpyvll	158	16	codon	codon	NN
cord-000372-wzwpyvll	158	17	is	be	VBZ
cord-000372-wzwpyvll	158	18	encountered	encounter	VBN
cord-000372-wzwpyvll	158	19	in	in	IN
cord-000372-wzwpyvll	158	20	a	a	DT
cord-000372-wzwpyvll	158	21	favourable	favourable	JJ
cord-000372-wzwpyvll	158	22	context	context	NN
cord-000372-wzwpyvll	158	23	.	.	.
cord-000372-wzwpyvll	159	1	The	the	DT
cord-000372-wzwpyvll	159	2	perfect	perfect	JJ
cord-000372-wzwpyvll	159	3	complementarity	complementarity	NN
cord-000372-wzwpyvll	159	4	between	between	IN
cord-000372-wzwpyvll	159	5	the	the	DT
cord-000372-wzwpyvll	159	6	AUG	AUG	NNP
cord-000372-wzwpyvll	159	7	start	start	NN
cord-000372-wzwpyvll	159	8	codon	codon	NN
cord-000372-wzwpyvll	159	9	and	and	CC
cord-000372-wzwpyvll	159	10	the	the	DT
cord-000372-wzwpyvll	159	11	anticodon	anticodon	NN
cord-000372-wzwpyvll	159	12	of	of	IN
cord-000372-wzwpyvll	160	1	Met	Met	NNP
cord-000372-wzwpyvll	160	2	-	-	HYPH
cord-000372-wzwpyvll	160	3	tRNA	tRNA	NNP
cord-000372-wzwpyvll	160	4	i	i	PRP
cord-000372-wzwpyvll	160	5	leads	lead	VBZ
cord-000372-wzwpyvll	160	6	to	to	IN
cord-000372-wzwpyvll	160	7	the	the	DT
cord-000372-wzwpyvll	160	8	arrest	arrest	NN
cord-000372-wzwpyvll	160	9	of	of	IN
cord-000372-wzwpyvll	160	10	scanning	scanning	NN
cord-000372-wzwpyvll	160	11	and	and	CC
cord-000372-wzwpyvll	160	12	the	the	DT
cord-000372-wzwpyvll	160	13	hydrolysis	hydrolysis	NN
cord-000372-wzwpyvll	160	14	of	of	IN
cord-000372-wzwpyvll	160	15	GTP	GTP	NNP
cord-000372-wzwpyvll	160	16	in	in	IN
cord-000372-wzwpyvll	160	17	the	the	DT
cord-000372-wzwpyvll	160	18	ternary	ternary	JJ
cord-000372-wzwpyvll	160	19	complex	complex	NN
cord-000372-wzwpyvll	160	20	.	.	.
cord-000372-wzwpyvll	161	1	The	the	DT
cord-000372-wzwpyvll	161	2	release	release	NN
cord-000372-wzwpyvll	161	3	of	of	IN
cord-000372-wzwpyvll	161	4	eIF2-GDP	eIF2-GDP	NNS
cord-000372-wzwpyvll	161	5	and	and	CC
cord-000372-wzwpyvll	161	6	other	other	JJ
cord-000372-wzwpyvll	161	7	factors	factor	NNS
cord-000372-wzwpyvll	161	8	triggers	trigger	VBZ
cord-000372-wzwpyvll	161	9	the	the	DT
cord-000372-wzwpyvll	161	10	interaction	interaction	NN
cord-000372-wzwpyvll	161	11	of	of	IN
cord-000372-wzwpyvll	161	12	the	the	DT
cord-000372-wzwpyvll	161	13	preinitiation	preinitiation	NN
cord-000372-wzwpyvll	161	14	complex	complex	NN
cord-000372-wzwpyvll	161	15	with	with	IN
cord-000372-wzwpyvll	161	16	the	the	DT
cord-000372-wzwpyvll	161	17	60S	60s	CD
cord-000372-wzwpyvll	161	18	ribosomal	ribosomal	JJ
cord-000372-wzwpyvll	161	19	subunit	subunit	NN
cord-000372-wzwpyvll	161	20	to	to	TO
cord-000372-wzwpyvll	161	21	form	form	VB
cord-000372-wzwpyvll	161	22	the	the	DT
cord-000372-wzwpyvll	161	23	80S	80s	CD
cord-000372-wzwpyvll	161	24	initiation	initiation	NN
cord-000372-wzwpyvll	161	25	complex	complex	NN
cord-000372-wzwpyvll	161	26	,	,	,
cord-000372-wzwpyvll	161	27	proceeding	proceed	VBG
cord-000372-wzwpyvll	161	28	to	to	IN
cord-000372-wzwpyvll	161	29	translation	translation	NN
cord-000372-wzwpyvll	161	30	of	of	IN
cord-000372-wzwpyvll	161	31	the	the	DT
cord-000372-wzwpyvll	161	32	mRNA	mRNA	NNP
cord-000372-wzwpyvll	161	33	coding	code	VBG
cord-000372-wzwpyvll	161	34	region	region	NN
cord-000372-wzwpyvll	161	35	.	.	.
cord-000372-wzwpyvll	162	1	A	a	DT
cord-000372-wzwpyvll	162	2	number	number	NN
cord-000372-wzwpyvll	162	3	of	of	IN
cord-000372-wzwpyvll	162	4	eukaryotic	eukaryotic	JJ
cord-000372-wzwpyvll	162	5	initiation	initiation	NN
cord-000372-wzwpyvll	162	6	factors	factor	NNS
cord-000372-wzwpyvll	162	7	participate	participate	VBP
cord-000372-wzwpyvll	162	8	in	in	IN
cord-000372-wzwpyvll	162	9	both	both	CC
cord-000372-wzwpyvll	162	10	mRNA	mrna	NN
cord-000372-wzwpyvll	162	11	binding	binding	NN
cord-000372-wzwpyvll	162	12	and	and	CC
cord-000372-wzwpyvll	162	13	scanning	scanning	NN
cord-000372-wzwpyvll	162	14	of	of	IN
cord-000372-wzwpyvll	162	15	the	the	DT
cord-000372-wzwpyvll	162	16	5	5	CD
cord-000372-wzwpyvll	162	17	UTR	UTR	NNP
cord-000372-wzwpyvll	162	18	of	of	IN
cord-000372-wzwpyvll	162	19	the	the	DT
cord-000372-wzwpyvll	162	20	mRNA	mrna	NN
cord-000372-wzwpyvll	162	21	by	by	IN
cord-000372-wzwpyvll	162	22	the	the	DT
cord-000372-wzwpyvll	162	23	small	small	JJ
cord-000372-wzwpyvll	162	24	ribosomal	ribosomal	JJ
cord-000372-wzwpyvll	162	25	subunit	subunit	NN
cord-000372-wzwpyvll	162	26	.	.	.
cord-000372-wzwpyvll	163	1	The	the	DT
cord-000372-wzwpyvll	163	2	cap	cap	NN
cord-000372-wzwpyvll	163	3	-	-	HYPH
cord-000372-wzwpyvll	163	4	binding	bind	VBG
cord-000372-wzwpyvll	163	5	protein	protein	NN
cord-000372-wzwpyvll	163	6	eIF4E	eif4e	CD
cord-000372-wzwpyvll	163	7	,	,	,
cord-000372-wzwpyvll	163	8	together	together	RB
cord-000372-wzwpyvll	163	9	with	with	IN
cord-000372-wzwpyvll	163	10	the	the	DT
cord-000372-wzwpyvll	163	11	DEAD	DEAD	NNP
cord-000372-wzwpyvll	163	12	-	-	HYPH
cord-000372-wzwpyvll	163	13	box	box	NN
cord-000372-wzwpyvll	163	14	helicase	helicase	NN
cord-000372-wzwpyvll	163	15	eIF4A	eif4a	CD
cord-000372-wzwpyvll	163	16	and	and	CC
cord-000372-wzwpyvll	163	17	the	the	DT
cord-000372-wzwpyvll	163	18	translation	translation	NN
cord-000372-wzwpyvll	163	19	initiation	initiation	NN
cord-000372-wzwpyvll	163	20	factor	factor	NN
cord-000372-wzwpyvll	164	1	eIF4	eif4	IN
cord-000372-wzwpyvll	164	2	G	G	NNP
cord-000372-wzwpyvll	164	3	,	,	,
cord-000372-wzwpyvll	164	4	forms	form	VBZ
cord-000372-wzwpyvll	164	5	the	the	DT
cord-000372-wzwpyvll	164	6	protein	protein	NN
cord-000372-wzwpyvll	164	7	complex	complex	NN
cord-000372-wzwpyvll	165	1	eIF4F.	eIF4F.	NNP
cord-000372-wzwpyvll	166	1	The	the	DT
cord-000372-wzwpyvll	166	2	heterotrimeric	heterotrimeric	JJ
cord-000372-wzwpyvll	166	3	complex	complex	JJ
cord-000372-wzwpyvll	166	4	eIF4F	eif4f	NN
cord-000372-wzwpyvll	166	5	is	be	VBZ
cord-000372-wzwpyvll	166	6	required	require	VBN
cord-000372-wzwpyvll	166	7	for	for	IN
cord-000372-wzwpyvll	166	8	recruiting	recruit	VBG
cord-000372-wzwpyvll	166	9	the	the	DT
cord-000372-wzwpyvll	166	10	43S	43s	JJ
cord-000372-wzwpyvll	166	11	preinitiation	preinitiation	NN
cord-000372-wzwpyvll	166	12	complex	complex	NN
cord-000372-wzwpyvll	166	13	onto	onto	IN
cord-000372-wzwpyvll	166	14	the	the	DT
cord-000372-wzwpyvll	166	15	cap	cap	NN
cord-000372-wzwpyvll	166	16	structure	structure	NN
cord-000372-wzwpyvll	166	17	located	locate	VBN
cord-000372-wzwpyvll	166	18	at	at	IN
cord-000372-wzwpyvll	166	19	the	the	DT
cord-000372-wzwpyvll	166	20	5	5	CD
cord-000372-wzwpyvll	166	21	end	end	NN
cord-000372-wzwpyvll	166	22	of	of	IN
cord-000372-wzwpyvll	166	23	the	the	DT
cord-000372-wzwpyvll	166	24	mRNA	mrna	NN
cord-000372-wzwpyvll	166	25	[	[	-LRB-
cord-000372-wzwpyvll	166	26	83	83	CD
cord-000372-wzwpyvll	166	27	]	]	-RRB-
cord-000372-wzwpyvll	166	28	.	.	.
cord-000372-wzwpyvll	167	1	In	in	IN
cord-000372-wzwpyvll	167	2	this	this	DT
cord-000372-wzwpyvll	167	3	sense	sense	NN
cord-000372-wzwpyvll	167	4	,	,	,
cord-000372-wzwpyvll	167	5	eIF4	eIF4	NNP
cord-000372-wzwpyvll	167	6	G	G	NNP
cord-000372-wzwpyvll	167	7	,	,	,
cord-000372-wzwpyvll	167	8	the	the	DT
cord-000372-wzwpyvll	167	9	larger	large	JJR
cord-000372-wzwpyvll	167	10	polypeptide	polypeptide	NN
cord-000372-wzwpyvll	167	11	of	of	IN
cord-000372-wzwpyvll	167	12	eIF4F	eif4f	CD
cord-000372-wzwpyvll	167	13	,	,	,
cord-000372-wzwpyvll	167	14	functions	function	NNS
cord-000372-wzwpyvll	167	15	as	as	IN
cord-000372-wzwpyvll	167	16	an	an	DT
cord-000372-wzwpyvll	167	17	adaptor	adaptor	NN
cord-000372-wzwpyvll	167	18	molecule	molecule	NN
cord-000372-wzwpyvll	167	19	that	that	WDT
cord-000372-wzwpyvll	167	20	bridges	bridge	VBZ
cord-000372-wzwpyvll	167	21	the	the	DT
cord-000372-wzwpyvll	167	22	mRNAs	mRNAs	NNPS
cord-000372-wzwpyvll	167	23	to	to	TO
cord-000372-wzwpyvll	167	24	ribosomes	ribosomes	VB
cord-000372-wzwpyvll	167	25	via	via	IN
cord-000372-wzwpyvll	167	26	interactions	interaction	NNS
cord-000372-wzwpyvll	167	27	with	with	IN
cord-000372-wzwpyvll	167	28	factors	factor	NNS
cord-000372-wzwpyvll	167	29	eIF4E	eif4e	CD
cord-000372-wzwpyvll	167	30	(	(	-LRB-
cord-000372-wzwpyvll	167	31	which	which	WDT
cord-000372-wzwpyvll	167	32	binds	bind	VBZ
cord-000372-wzwpyvll	167	33	the	the	DT
cord-000372-wzwpyvll	167	34	5	5	CD
cord-000372-wzwpyvll	167	35	cap	cap	NN
cord-000372-wzwpyvll	167	36	structure	structure	NN
cord-000372-wzwpyvll	167	37	)	)	-RRB-
cord-000372-wzwpyvll	167	38	,	,	,
cord-000372-wzwpyvll	167	39	PABP	PABP	NNP
cord-000372-wzwpyvll	167	40	(	(	-LRB-
cord-000372-wzwpyvll	167	41	which	which	WDT
cord-000372-wzwpyvll	167	42	binds	bind	VBZ
cord-000372-wzwpyvll	167	43	the	the	DT
cord-000372-wzwpyvll	167	44	poly(A	poly(a	JJ
cord-000372-wzwpyvll	167	45	)	)	-RRB-
cord-000372-wzwpyvll	167	46	tail	tail	NN
cord-000372-wzwpyvll	167	47	)	)	-RRB-
cord-000372-wzwpyvll	167	48	,	,	,
cord-000372-wzwpyvll	167	49	and	and	CC
cord-000372-wzwpyvll	167	50	eIF3	eIF3	NNP
cord-000372-wzwpyvll	167	51	,	,	,
cord-000372-wzwpyvll	167	52	which	which	WDT
cord-000372-wzwpyvll	167	53	interacts	interact	VBZ
cord-000372-wzwpyvll	167	54	with	with	IN
cord-000372-wzwpyvll	167	55	the	the	DT
cord-000372-wzwpyvll	167	56	40S	40s	CD
cord-000372-wzwpyvll	167	57	ribosome	ribosome	NN
cord-000372-wzwpyvll	167	58	subunit	subunit	NN
cord-000372-wzwpyvll	167	59	(	(	-LRB-
cord-000372-wzwpyvll	167	60	Figure	figure	NN
cord-000372-wzwpyvll	167	61	3	3	CD
cord-000372-wzwpyvll	167	62	)	)	-RRB-
cord-000372-wzwpyvll	167	63	[	[	-LRB-
cord-000372-wzwpyvll	167	64	81	81	CD
cord-000372-wzwpyvll	167	65	,	,	,
cord-000372-wzwpyvll	167	66	[	[	-LRB-
cord-000372-wzwpyvll	167	67	84	84	CD
cord-000372-wzwpyvll	167	68	]	]	-RRB-
cord-000372-wzwpyvll	167	69	[	[	-LRB-
cord-000372-wzwpyvll	167	70	85	85	CD
cord-000372-wzwpyvll	167	71	]	]	-RRB-
cord-000372-wzwpyvll	167	72	[	[	-LRB-
cord-000372-wzwpyvll	167	73	86	86	CD
cord-000372-wzwpyvll	167	74	]	]	-RRB-
cord-000372-wzwpyvll	167	75	.	.	.
cord-000372-wzwpyvll	168	1	In	in	IN
cord-000372-wzwpyvll	168	2	addition	addition	NN
cord-000372-wzwpyvll	168	3	,	,	,
cord-000372-wzwpyvll	168	4	eIF4	eIF4	NNP
cord-000372-wzwpyvll	168	5	G	G	NNP
cord-000372-wzwpyvll	168	6	also	also	RB
cord-000372-wzwpyvll	168	7	contains	contain	VBZ
cord-000372-wzwpyvll	168	8	binding	bind	VBG
cord-000372-wzwpyvll	168	9	sites	site	NNS
cord-000372-wzwpyvll	168	10	for	for	IN
cord-000372-wzwpyvll	168	11	other	other	JJ
cord-000372-wzwpyvll	168	12	polypeptides	polypeptide	NNS
cord-000372-wzwpyvll	168	13	involved	involve	VBN
cord-000372-wzwpyvll	168	14	in	in	IN
cord-000372-wzwpyvll	168	15	translation	translation	NN
cord-000372-wzwpyvll	168	16	,	,	,
cord-000372-wzwpyvll	168	17	such	such	JJ
cord-000372-wzwpyvll	168	18	as	as	IN
cord-000372-wzwpyvll	168	19	the	the	DT
cord-000372-wzwpyvll	168	20	RNA	RNA	NNP
cord-000372-wzwpyvll	168	21	helicase	helicase	NN
cord-000372-wzwpyvll	168	22	eIF4A	eif4a	CD
cord-000372-wzwpyvll	169	1	(	(	-LRB-
cord-000372-wzwpyvll	169	2	Figure	figure	NN
cord-000372-wzwpyvll	169	3	3	3	CD
cord-000372-wzwpyvll	169	4	)	)	-RRB-
cord-000372-wzwpyvll	169	5	[	[	-LRB-
cord-000372-wzwpyvll	169	6	87	87	CD
cord-000372-wzwpyvll	169	7	]	]	-RRB-
cord-000372-wzwpyvll	169	8	,	,	,
cord-000372-wzwpyvll	169	9	which	which	WDT
cord-000372-wzwpyvll	169	10	is	be	VBZ
cord-000372-wzwpyvll	169	11	required	require	VBN
cord-000372-wzwpyvll	169	12	to	to	TO
cord-000372-wzwpyvll	169	13	unwind	unwind	VB
cord-000372-wzwpyvll	169	14	the	the	DT
cord-000372-wzwpyvll	169	15	secondary	secondary	JJ
cord-000372-wzwpyvll	169	16	structure	structure	NN
cord-000372-wzwpyvll	169	17	within	within	IN
cord-000372-wzwpyvll	169	18	the	the	DT
cord-000372-wzwpyvll	169	19	mRNA	mrna	NN
cord-000372-wzwpyvll	169	20	5	5	CD
cord-000372-wzwpyvll	169	21	leader	leader	NN
cord-000372-wzwpyvll	169	22	sequence	sequence	NN
cord-000372-wzwpyvll	169	23	that	that	WDT
cord-000372-wzwpyvll	169	24	would	would	MD
cord-000372-wzwpyvll	169	25	otherwise	otherwise	RB
cord-000372-wzwpyvll	169	26	inhibit	inhibit	VB
cord-000372-wzwpyvll	169	27	ribosome	ribosome	NN
cord-000372-wzwpyvll	169	28	scanning	scanning	NN
cord-000372-wzwpyvll	169	29	.	.	.
cord-000372-wzwpyvll	170	1	The	the	DT
cord-000372-wzwpyvll	170	2	simultaneous	simultaneous	JJ
cord-000372-wzwpyvll	170	3	interaction	interaction	NN
cord-000372-wzwpyvll	170	4	of	of	IN
cord-000372-wzwpyvll	170	5	eIF4	eIF4	NNP
cord-000372-wzwpyvll	170	6	G	G	NNP
cord-000372-wzwpyvll	170	7	with	with	IN
cord-000372-wzwpyvll	170	8	eIF4E	eif4e	CD
cord-000372-wzwpyvll	170	9	and	and	CC
cord-000372-wzwpyvll	170	10	PABP	PABP	NNP
cord-000372-wzwpyvll	170	11	promotes	promote	VBZ
cord-000372-wzwpyvll	170	12	circularization	circularization	NN
cord-000372-wzwpyvll	170	13	of	of	IN
cord-000372-wzwpyvll	170	14	the	the	DT
cord-000372-wzwpyvll	170	15	mRNA	mrna	NN
cord-000372-wzwpyvll	170	16	in	in	IN
cord-000372-wzwpyvll	170	17	a	a	DT
cord-000372-wzwpyvll	170	18	closed	closed	JJ
cord-000372-wzwpyvll	170	19	loop	loop	NN
cord-000372-wzwpyvll	170	20	that	that	WDT
cord-000372-wzwpyvll	170	21	facilitates	facilitate	VBZ
cord-000372-wzwpyvll	170	22	the	the	DT
cord-000372-wzwpyvll	170	23	initiation	initiation	NN
cord-000372-wzwpyvll	170	24	of	of	IN
cord-000372-wzwpyvll	170	25	new	new	JJ
cord-000372-wzwpyvll	170	26	rounds	round	NNS
cord-000372-wzwpyvll	170	27	of	of	IN
cord-000372-wzwpyvll	170	28	translation	translation	NN
cord-000372-wzwpyvll	170	29	by	by	IN
cord-000372-wzwpyvll	170	30	the	the	DT
cord-000372-wzwpyvll	170	31	proximity	proximity	NN
cord-000372-wzwpyvll	170	32	of	of	IN
cord-000372-wzwpyvll	170	33	the	the	DT
cord-000372-wzwpyvll	170	34	5	5	CD
cord-000372-wzwpyvll	170	35	and	and	CC
cord-000372-wzwpyvll	170	36	3	3	CD
cord-000372-wzwpyvll	170	37	ends	end	VBZ
cord-000372-wzwpyvll	170	38	[	[	-LRB-
cord-000372-wzwpyvll	170	39	88	88	CD
cord-000372-wzwpyvll	170	40	,	,	,
cord-000372-wzwpyvll	170	41	89	89	CD
cord-000372-wzwpyvll	170	42	]	]	-RRB-
cord-000372-wzwpyvll	170	43	.	.	.
cord-000372-wzwpyvll	171	1	Furthermore	furthermore	RB
cord-000372-wzwpyvll	171	2	,	,	,
cord-000372-wzwpyvll	171	3	eIF4	eIF4	NNP
cord-000372-wzwpyvll	171	4	G	G	NNP
cord-000372-wzwpyvll	171	5	also	also	RB
cord-000372-wzwpyvll	171	6	interacts	interact	VBZ
cord-000372-wzwpyvll	171	7	with	with	IN
cord-000372-wzwpyvll	171	8	the	the	DT
cord-000372-wzwpyvll	171	9	mitogen	mitogen	NN
cord-000372-wzwpyvll	171	10	-	-	HYPH
cord-000372-wzwpyvll	171	11	activated	activate	VBN
cord-000372-wzwpyvll	171	12	protein	protein	NN
cord-000372-wzwpyvll	171	13	kinase	kinase	NN
cord-000372-wzwpyvll	171	14	1	1	CD
cord-000372-wzwpyvll	171	15	(	(	-LRB-
cord-000372-wzwpyvll	171	16	Mnk1	mnk1	NN
cord-000372-wzwpyvll	171	17	)	)	-RRB-
cord-000372-wzwpyvll	172	1	(	(	-LRB-
cord-000372-wzwpyvll	172	2	Figure	figure	NN
cord-000372-wzwpyvll	172	3	3	3	CD
cord-000372-wzwpyvll	172	4	)	)	-RRB-
cord-000372-wzwpyvll	172	5	,	,	,
cord-000372-wzwpyvll	172	6	which	which	WDT
cord-000372-wzwpyvll	172	7	phosphorylates	phosphorylate	VBZ
cord-000372-wzwpyvll	172	8	eIF4E	eif4e	CD
cord-000372-wzwpyvll	172	9	,	,	,
cord-000372-wzwpyvll	172	10	although	although	IN
cord-000372-wzwpyvll	172	11	the	the	DT
cord-000372-wzwpyvll	172	12	role	role	NN
cord-000372-wzwpyvll	172	13	of	of	IN
cord-000372-wzwpyvll	172	14	this	this	DT
cord-000372-wzwpyvll	172	15	phosphorylation	phosphorylation	NN
cord-000372-wzwpyvll	172	16	in	in	IN
cord-000372-wzwpyvll	172	17	the	the	DT
cord-000372-wzwpyvll	172	18	initiation	initiation	NN
cord-000372-wzwpyvll	172	19	of	of	IN
cord-000372-wzwpyvll	172	20	translation	translation	NN
cord-000372-wzwpyvll	172	21	in	in	IN
cord-000372-wzwpyvll	172	22	still	still	RB
cord-000372-wzwpyvll	172	23	unclear	unclear	JJ
cord-000372-wzwpyvll	172	24	[	[	-LRB-
cord-000372-wzwpyvll	172	25	90	90	CD
cord-000372-wzwpyvll	172	26	]	]	-RRB-
cord-000372-wzwpyvll	172	27	[	[	-LRB-
cord-000372-wzwpyvll	172	28	91	91	CD
cord-000372-wzwpyvll	172	29	]	]	-RRB-
cord-000372-wzwpyvll	172	30	[	[	-LRB-
cord-000372-wzwpyvll	172	31	92	92	CD
cord-000372-wzwpyvll	172	32	]	]	-RRB-
cord-000372-wzwpyvll	172	33	[	[	-LRB-
cord-000372-wzwpyvll	172	34	93	93	CD
cord-000372-wzwpyvll	172	35	]	]	-RRB-
cord-000372-wzwpyvll	172	36	[	[	-LRB-
cord-000372-wzwpyvll	172	37	94	94	CD
cord-000372-wzwpyvll	172	38	]	]	-RRB-
cord-000372-wzwpyvll	172	39	.	.	.
cord-000372-wzwpyvll	173	1	Two	two	CD
cord-000372-wzwpyvll	173	2	forms	form	NNS
cord-000372-wzwpyvll	173	3	of	of	IN
cord-000372-wzwpyvll	173	4	eIF4	eIF4	NNP
cord-000372-wzwpyvll	173	5	G	G	NNP
cord-000372-wzwpyvll	173	6	,	,	,
cord-000372-wzwpyvll	173	7	known	know	VBN
cord-000372-wzwpyvll	173	8	as	as	IN
cord-000372-wzwpyvll	173	9	eIF4GI	eIF4GI	NNS
cord-000372-wzwpyvll	173	10	and	and	CC
cord-000372-wzwpyvll	173	11	eIF4GII	eIF4GII	NNS
cord-000372-wzwpyvll	173	12	,	,	,
cord-000372-wzwpyvll	173	13	have	have	VBP
cord-000372-wzwpyvll	173	14	been	be	VBN
cord-000372-wzwpyvll	173	15	identified	identify	VBN
cord-000372-wzwpyvll	173	16	in	in	IN
cord-000372-wzwpyvll	173	17	mammalian	mammalian	JJ
cord-000372-wzwpyvll	173	18	cells	cell	NNS
cord-000372-wzwpyvll	173	19	.	.	.
cord-000372-wzwpyvll	174	1	Both	both	DT
cord-000372-wzwpyvll	174	2	forms	form	NNS
cord-000372-wzwpyvll	174	3	show	show	VBP
cord-000372-wzwpyvll	174	4	only	only	RB
cord-000372-wzwpyvll	174	5	46	46	CD
cord-000372-wzwpyvll	174	6	%	%	NN
cord-000372-wzwpyvll	174	7	amino	amino	NN
cord-000372-wzwpyvll	174	8	acid	acid	NN
cord-000372-wzwpyvll	174	9	sequence	sequence	NN
cord-000372-wzwpyvll	174	10	identity	identity	NN
cord-000372-wzwpyvll	174	11	but	but	CC
cord-000372-wzwpyvll	174	12	they	-PRON-	PRP
cord-000372-wzwpyvll	174	13	are	be	VBP
cord-000372-wzwpyvll	174	14	thought	think	VBN
cord-000372-wzwpyvll	174	15	to	to	TO
cord-000372-wzwpyvll	174	16	be	be	VB
cord-000372-wzwpyvll	174	17	functionally	functionally	RB
cord-000372-wzwpyvll	174	18	interchangeable	interchangeable	JJ
cord-000372-wzwpyvll	174	19	due	due	IN
cord-000372-wzwpyvll	174	20	to	to	IN
cord-000372-wzwpyvll	174	21	the	the	DT
cord-000372-wzwpyvll	174	22	high	high	JJ
cord-000372-wzwpyvll	174	23	homology	homology	NN
cord-000372-wzwpyvll	174	24	in	in	IN
cord-000372-wzwpyvll	174	25	key	key	JJ
cord-000372-wzwpyvll	174	26	domains	domain	NNS
cord-000372-wzwpyvll	174	27	that	that	WDT
cord-000372-wzwpyvll	174	28	interact	interact	VBP
cord-000372-wzwpyvll	174	29	with	with	IN
cord-000372-wzwpyvll	174	30	other	other	JJ
cord-000372-wzwpyvll	174	31	factors	factor	NNS
cord-000372-wzwpyvll	174	32	[	[	-LRB-
cord-000372-wzwpyvll	174	33	88	88	CD
cord-000372-wzwpyvll	174	34	]	]	-RRB-
cord-000372-wzwpyvll	174	35	.	.	.
cord-000372-wzwpyvll	175	1	Evidence	evidence	NN
cord-000372-wzwpyvll	175	2	obtained	obtain	VBN
cord-000372-wzwpyvll	175	3	by	by	IN
cord-000372-wzwpyvll	175	4	specific	specific	JJ
cord-000372-wzwpyvll	175	5	depletion	depletion	NN
cord-000372-wzwpyvll	175	6	of	of	IN
cord-000372-wzwpyvll	175	7	each	each	DT
cord-000372-wzwpyvll	175	8	eIF4	eIF4	NNP
cord-000372-wzwpyvll	175	9	G	g	NN
cord-000372-wzwpyvll	175	10	form	form	NN
cord-000372-wzwpyvll	175	11	or	or	CC
cord-000372-wzwpyvll	175	12	differential	differential	JJ
cord-000372-wzwpyvll	175	13	cleavage	cleavage	NN
cord-000372-wzwpyvll	175	14	of	of	IN
cord-000372-wzwpyvll	175	15	each	each	DT
cord-000372-wzwpyvll	175	16	of	of	IN
cord-000372-wzwpyvll	175	17	them	-PRON-	PRP
cord-000372-wzwpyvll	175	18	by	by	IN
cord-000372-wzwpyvll	175	19	specific	specific	JJ
cord-000372-wzwpyvll	175	20	proteases	protease	NNS
cord-000372-wzwpyvll	175	21	(	(	-LRB-
cord-000372-wzwpyvll	175	22	see	see	VB
cord-000372-wzwpyvll	175	23	below	below	RB
cord-000372-wzwpyvll	175	24	)	)	-RRB-
cord-000372-wzwpyvll	175	25	points	point	NNS
cord-000372-wzwpyvll	175	26	to	to	IN
cord-000372-wzwpyvll	175	27	the	the	DT
cord-000372-wzwpyvll	175	28	idea	idea	NN
cord-000372-wzwpyvll	175	29	that	that	IN
cord-000372-wzwpyvll	175	30	both	both	DT
cord-000372-wzwpyvll	175	31	factors	factor	NNS
cord-000372-wzwpyvll	175	32	should	should	MD
cord-000372-wzwpyvll	175	33	be	be	VB
cord-000372-wzwpyvll	175	34	lacking	lack	VBG
cord-000372-wzwpyvll	175	35	for	for	IN
cord-000372-wzwpyvll	175	36	complete	complete	JJ
cord-000372-wzwpyvll	175	37	abolition	abolition	NN
cord-000372-wzwpyvll	175	38	of	of	IN
cord-000372-wzwpyvll	175	39	protein	protein	NN
cord-000372-wzwpyvll	175	40	synthesis	synthesis	NN
cord-000372-wzwpyvll	175	41	[	[	-LRB-
cord-000372-wzwpyvll	175	42	95	95	CD
cord-000372-wzwpyvll	175	43	,	,	,
cord-000372-wzwpyvll	175	44	96	96	CD
cord-000372-wzwpyvll	175	45	]	]	-RRB-
cord-000372-wzwpyvll	175	46	.	.	.
cord-000372-wzwpyvll	176	1	eIF4GI	eIF4GI	NNS
cord-000372-wzwpyvll	176	2	is	be	VBZ
cord-000372-wzwpyvll	176	3	the	the	DT
cord-000372-wzwpyvll	176	4	dominant	dominant	JJ
cord-000372-wzwpyvll	176	5	form	form	NN
cord-000372-wzwpyvll	176	6	in	in	IN
cord-000372-wzwpyvll	176	7	HeLa	HeLa	NNP
cord-000372-wzwpyvll	176	8	cells	cell	NNS
cord-000372-wzwpyvll	176	9	,	,	,
cord-000372-wzwpyvll	176	10	in	in	IN
cord-000372-wzwpyvll	176	11	which	which	WDT
cord-000372-wzwpyvll	176	12	the	the	DT
cord-000372-wzwpyvll	176	13	ratio	ratio	NN
cord-000372-wzwpyvll	176	14	between	between	IN
cord-000372-wzwpyvll	176	15	eIFGI	eIFGI	NNP
cord-000372-wzwpyvll	176	16	and	and	CC
cord-000372-wzwpyvll	176	17	eIF4GII	eif4gii	NN
cord-000372-wzwpyvll	176	18	is	be	VBZ
cord-000372-wzwpyvll	176	19	9	9	CD
cord-000372-wzwpyvll	176	20	:	:	SYM
cord-000372-wzwpyvll	176	21	1	1	CD
cord-000372-wzwpyvll	176	22	[	[	-LRB-
cord-000372-wzwpyvll	176	23	97	97	CD
cord-000372-wzwpyvll	176	24	]	]	-RRB-
cord-000372-wzwpyvll	176	25	.	.	.
cord-000372-wzwpyvll	177	1	However	however	RB
cord-000372-wzwpyvll	177	2	,	,	,
cord-000372-wzwpyvll	177	3	the	the	DT
cord-000372-wzwpyvll	177	4	specific	specific	JJ
cord-000372-wzwpyvll	177	5	role	role	NN
cord-000372-wzwpyvll	177	6	of	of	IN
cord-000372-wzwpyvll	177	7	each	each	DT
cord-000372-wzwpyvll	177	8	form	form	NN
cord-000372-wzwpyvll	177	9	of	of	IN
cord-000372-wzwpyvll	177	10	eIF4	eIF4	NNP
cord-000372-wzwpyvll	177	11	G	g	NN
cord-000372-wzwpyvll	177	12	in	in	IN
cord-000372-wzwpyvll	177	13	the	the	DT
cord-000372-wzwpyvll	177	14	initiation	initiation	NN
cord-000372-wzwpyvll	177	15	of	of	IN
cord-000372-wzwpyvll	177	16	translation	translation	NN
cord-000372-wzwpyvll	177	17	remains	remain	VBZ
cord-000372-wzwpyvll	177	18	unknown	unknown	JJ
cord-000372-wzwpyvll	177	19	.	.	.
cord-000372-wzwpyvll	178	1	It	-PRON-	PRP
cord-000372-wzwpyvll	178	2	was	be	VBD
cord-000372-wzwpyvll	178	3	proposed	propose	VBN
cord-000372-wzwpyvll	178	4	that	that	IN
cord-000372-wzwpyvll	178	5	both	both	DT
cord-000372-wzwpyvll	178	6	eIF4	eif4	IN
cord-000372-wzwpyvll	178	7	G	g	NN
cord-000372-wzwpyvll	178	8	forms	form	NNS
cord-000372-wzwpyvll	178	9	are	be	VBP
cord-000372-wzwpyvll	178	10	differentially	differentially	RB
cord-000372-wzwpyvll	178	11	regulated	regulate	VBN
cord-000372-wzwpyvll	178	12	by	by	IN
cord-000372-wzwpyvll	178	13	different	different	JJ
cord-000372-wzwpyvll	178	14	kinases	kinase	NNS
cord-000372-wzwpyvll	178	15	,	,	,
cord-000372-wzwpyvll	178	16	supporting	support	VBG
cord-000372-wzwpyvll	178	17	the	the	DT
cord-000372-wzwpyvll	178	18	hypothesis	hypothesis	NN
cord-000372-wzwpyvll	178	19	that	that	WDT
cord-000372-wzwpyvll	178	20	eIF4GI	eIF4GI	VBZ
cord-000372-wzwpyvll	178	21	and	and	CC
cord-000372-wzwpyvll	178	22	eIF4GII	eif4gii	PRP
cord-000372-wzwpyvll	178	23	could	could	MD
cord-000372-wzwpyvll	178	24	drive	drive	VB
cord-000372-wzwpyvll	178	25	differentially	differentially	RB
cord-000372-wzwpyvll	178	26	translation	translation	NN
cord-000372-wzwpyvll	178	27	initiation	initiation	NN
cord-000372-wzwpyvll	178	28	[	[	-LRB-
cord-000372-wzwpyvll	178	29	98	98	CD
cord-000372-wzwpyvll	178	30	]	]	-RRB-
cord-000372-wzwpyvll	178	31	.	.	.
cord-000372-wzwpyvll	179	1	eIF4GI	eIF4GI	NNS
cord-000372-wzwpyvll	179	2	is	be	VBZ
cord-000372-wzwpyvll	179	3	phosphorylated	phosphorylate	VBN
cord-000372-wzwpyvll	179	4	in	in	IN
cord-000372-wzwpyvll	179	5	response	response	NN
cord-000372-wzwpyvll	179	6	to	to	IN
cord-000372-wzwpyvll	179	7	serum	serum	NN
cord-000372-wzwpyvll	179	8	and	and	CC
cord-000372-wzwpyvll	179	9	in	in	IN
cord-000372-wzwpyvll	179	10	a	a	DT
cord-000372-wzwpyvll	179	11	rapamycin	rapamycin	NN
cord-000372-wzwpyvll	179	12	-	-	HYPH
cord-000372-wzwpyvll	179	13	dependent	dependent	JJ
cord-000372-wzwpyvll	179	14	manner	manner	NN
cord-000372-wzwpyvll	179	15	at	at	IN
cord-000372-wzwpyvll	179	16	Ser	Ser	NNP
cord-000372-wzwpyvll	179	17	1148	1148	CD
cord-000372-wzwpyvll	179	18	,	,	,
cord-000372-wzwpyvll	179	19	1188	1188	CD
cord-000372-wzwpyvll	179	20	,	,	,
cord-000372-wzwpyvll	179	21	and	and	CC
cord-000372-wzwpyvll	179	22	1232	1232	CD
cord-000372-wzwpyvll	179	23	,	,	,
cord-000372-wzwpyvll	179	24	although	although	IN
cord-000372-wzwpyvll	179	25	the	the	DT
cord-000372-wzwpyvll	179	26	role	role	NN
cord-000372-wzwpyvll	179	27	of	of	IN
cord-000372-wzwpyvll	179	28	these	these	DT
cord-000372-wzwpyvll	179	29	posttranslational	posttranslational	JJ
cord-000372-wzwpyvll	179	30	modifications	modification	NNS
cord-000372-wzwpyvll	179	31	is	be	VBZ
cord-000372-wzwpyvll	179	32	still	still	RB
cord-000372-wzwpyvll	179	33	under	under	IN
cord-000372-wzwpyvll	179	34	investigation	investigation	NN
cord-000372-wzwpyvll	179	35	[	[	-LRB-
cord-000372-wzwpyvll	179	36	99	99	CD
cord-000372-wzwpyvll	179	37	]	]	-RRB-
cord-000372-wzwpyvll	179	38	.	.	.
cord-000372-wzwpyvll	180	1	In	in	IN
cord-000372-wzwpyvll	180	2	addition	addition	NN
cord-000372-wzwpyvll	180	3	,	,	,
cord-000372-wzwpyvll	180	4	eIF4GI	eIF4GI	NNS
cord-000372-wzwpyvll	180	5	is	be	VBZ
cord-000372-wzwpyvll	180	6	phosphorylated	phosphorylate	VBN
cord-000372-wzwpyvll	180	7	by	by	IN
cord-000372-wzwpyvll	180	8	p21-activated	p21-activated	JJ
cord-000372-wzwpyvll	180	9	protein	protein	NN
cord-000372-wzwpyvll	180	10	kinase	kinase	NN
cord-000372-wzwpyvll	180	11	(	(	-LRB-
cord-000372-wzwpyvll	180	12	Pak-2	Pak-2	NNP
cord-000372-wzwpyvll	180	13	)	)	-RRB-
cord-000372-wzwpyvll	180	14	that	that	WDT
cord-000372-wzwpyvll	180	15	is	be	VBZ
cord-000372-wzwpyvll	180	16	induced	induce	VBN
cord-000372-wzwpyvll	180	17	under	under	IN
cord-000372-wzwpyvll	180	18	stress	stress	NN
cord-000372-wzwpyvll	180	19	conditions	condition	NNS
cord-000372-wzwpyvll	180	20	.	.	.
cord-000372-wzwpyvll	181	1	This	this	DT
cord-000372-wzwpyvll	181	2	phosphorylation	phosphorylation	NN
cord-000372-wzwpyvll	181	3	takes	take	VBZ
cord-000372-wzwpyvll	181	4	place	place	NN
cord-000372-wzwpyvll	181	5	in	in	IN
cord-000372-wzwpyvll	181	6	the	the	DT
cord-000372-wzwpyvll	181	7	eIF4E	eif4e	CD
cord-000372-wzwpyvll	181	8	-	-	HYPH
cord-000372-wzwpyvll	181	9	binding	bind	VBG
cord-000372-wzwpyvll	181	10	site	site	NN
cord-000372-wzwpyvll	181	11	of	of	IN
cord-000372-wzwpyvll	181	12	eIF4	eIF4	NNP
cord-000372-wzwpyvll	181	13	G	G	NNP
cord-000372-wzwpyvll	181	14	and	and	CC
cord-000372-wzwpyvll	181	15	avoids	avoid	VBZ
cord-000372-wzwpyvll	181	16	the	the	DT
cord-000372-wzwpyvll	181	17	interaction	interaction	NN
cord-000372-wzwpyvll	181	18	between	between	IN
cord-000372-wzwpyvll	181	19	these	these	DT
cord-000372-wzwpyvll	181	20	two	two	CD
cord-000372-wzwpyvll	181	21	factors	factor	NNS
cord-000372-wzwpyvll	181	22	,	,	,
cord-000372-wzwpyvll	181	23	inhibiting	inhibit	VBG
cord-000372-wzwpyvll	181	24	cap	cap	NN
cord-000372-wzwpyvll	181	25	-	-	HYPH
cord-000372-wzwpyvll	181	26	dependent	dependent	JJ
cord-000372-wzwpyvll	181	27	initiation	initiation	NN
cord-000372-wzwpyvll	181	28	of	of	IN
cord-000372-wzwpyvll	181	29	translation	translation	NN
cord-000372-wzwpyvll	181	30	[	[	-LRB-
cord-000372-wzwpyvll	181	31	100	100	CD
cord-000372-wzwpyvll	181	32	]	]	-RRB-
cord-000372-wzwpyvll	181	33	.	.	.
cord-000372-wzwpyvll	182	1	On	on	IN
cord-000372-wzwpyvll	182	2	the	the	DT
cord-000372-wzwpyvll	182	3	other	other	JJ
cord-000372-wzwpyvll	182	4	hand	hand	NN
cord-000372-wzwpyvll	182	5	,	,	,
cord-000372-wzwpyvll	182	6	eIF4GII	eif4gii	NN
cord-000372-wzwpyvll	182	7	is	be	VBZ
cord-000372-wzwpyvll	182	8	phosphorylated	phosphorylate	VBN
cord-000372-wzwpyvll	182	9	during	during	IN
cord-000372-wzwpyvll	182	10	mitosis	mitosis	NN
cord-000372-wzwpyvll	182	11	[	[	-LRB-
cord-000372-wzwpyvll	182	12	101	101	CD
cord-000372-wzwpyvll	182	13	]	]	-RRB-
cord-000372-wzwpyvll	182	14	by	by	IN
cord-000372-wzwpyvll	182	15	calmodulin	calmodulin	NN
cord-000372-wzwpyvll	182	16	-	-	HYPH
cord-000372-wzwpyvll	182	17	dependent	dependent	JJ
cord-000372-wzwpyvll	182	18	kinase	kinase	NN
cord-000372-wzwpyvll	182	19	I	-PRON-	PRP
cord-000372-wzwpyvll	182	20	at	at	IN
cord-000372-wzwpyvll	182	21	Ser	Ser	NNP
cord-000372-wzwpyvll	182	22	1156	1156	CD
cord-000372-wzwpyvll	182	23	[	[	-LRB-
cord-000372-wzwpyvll	182	24	102	102	CD
cord-000372-wzwpyvll	182	25	]	]	-RRB-
cord-000372-wzwpyvll	182	26	.	.	.
cord-000372-wzwpyvll	183	1	Therefore	therefore	RB
cord-000372-wzwpyvll	183	2	,	,	,
cord-000372-wzwpyvll	183	3	activity	activity	NN
cord-000372-wzwpyvll	183	4	of	of	IN
cord-000372-wzwpyvll	183	5	eIF4GI	eif4gi	NN
cord-000372-wzwpyvll	183	6	and	and	CC
cord-000372-wzwpyvll	183	7	eIF4GII	eIF4GII	NNS
cord-000372-wzwpyvll	183	8	might	may	MD
cord-000372-wzwpyvll	183	9	be	be	VB
cord-000372-wzwpyvll	183	10	tightly	tightly	RB
cord-000372-wzwpyvll	183	11	and	and	CC
cord-000372-wzwpyvll	183	12	reversibly	reversibly	RB
cord-000372-wzwpyvll	183	13	regulated	regulate	VBN
cord-000372-wzwpyvll	183	14	by	by	IN
cord-000372-wzwpyvll	183	15	phosphorylation	phosphorylation	NN
cord-000372-wzwpyvll	183	16	under	under	IN
cord-000372-wzwpyvll	183	17	different	different	JJ
cord-000372-wzwpyvll	183	18	physiological	physiological	JJ
cord-000372-wzwpyvll	183	19	conditions	condition	NNS
cord-000372-wzwpyvll	183	20	.	.	.
cord-000372-wzwpyvll	184	1	Nevertheless	nevertheless	RB
cord-000372-wzwpyvll	184	2	,	,	,
cord-000372-wzwpyvll	184	3	this	this	DT
cord-000372-wzwpyvll	184	4	factor	factor	NN
cord-000372-wzwpyvll	184	5	is	be	VBZ
cord-000372-wzwpyvll	184	6	also	also	RB
cord-000372-wzwpyvll	184	7	subjected	subject	VBN
cord-000372-wzwpyvll	184	8	to	to	IN
cord-000372-wzwpyvll	184	9	irreversible	irreversible	JJ
cord-000372-wzwpyvll	184	10	modifications	modification	NNS
cord-000372-wzwpyvll	184	11	such	such	JJ
cord-000372-wzwpyvll	184	12	as	as	IN
cord-000372-wzwpyvll	184	13	caspasemediated	caspasemediated	JJ
cord-000372-wzwpyvll	184	14	proteolysis	proteolysis	NN
cord-000372-wzwpyvll	184	15	,	,	,
cord-000372-wzwpyvll	184	16	which	which	WDT
cord-000372-wzwpyvll	184	17	is	be	VBZ
cord-000372-wzwpyvll	184	18	triggered	trigger	VBN
cord-000372-wzwpyvll	184	19	during	during	IN
cord-000372-wzwpyvll	184	20	apoptosis	apoptosis	NN
cord-000372-wzwpyvll	184	21	and	and	CC
cord-000372-wzwpyvll	184	22	leads	lead	VBZ
cord-000372-wzwpyvll	184	23	to	to	IN
cord-000372-wzwpyvll	184	24	shutoff	shutoff	NN
cord-000372-wzwpyvll	184	25	of	of	IN
cord-000372-wzwpyvll	184	26	protein	protein	NN
cord-000372-wzwpyvll	184	27	synthesis	synthesis	NN
cord-000372-wzwpyvll	184	28	.	.	.
cord-000372-wzwpyvll	185	1	Caspase-3	Caspase-3	NNP
cord-000372-wzwpyvll	185	2	cleaves	cleave	VBZ
cord-000372-wzwpyvll	185	3	directly	directly	RB
cord-000372-wzwpyvll	185	4	eIF4GI	eIF4GI	NNS
cord-000372-wzwpyvll	185	5	in	in	IN
cord-000372-wzwpyvll	185	6	positions	position	NNS
cord-000372-wzwpyvll	185	7	532	532	CD
cord-000372-wzwpyvll	185	8	and	and	CC
cord-000372-wzwpyvll	185	9	1175	1175	CD
cord-000372-wzwpyvll	185	10	removing	remove	VBG
cord-000372-wzwpyvll	185	11	PABP	PABP	NNP
cord-000372-wzwpyvll	185	12	,	,	,
cord-000372-wzwpyvll	185	13	Mnk1	Mnk1	NNP
cord-000372-wzwpyvll	185	14	,	,	,
cord-000372-wzwpyvll	185	15	and	and	CC
cord-000372-wzwpyvll	185	16	one	one	CD
cord-000372-wzwpyvll	185	17	eIF4A	eif4a	NN
cord-000372-wzwpyvll	185	18	-	-	HYPH
cord-000372-wzwpyvll	185	19	binding	bind	VBG
cord-000372-wzwpyvll	185	20	domain	domain	NN
cord-000372-wzwpyvll	185	21	from	from	IN
cord-000372-wzwpyvll	185	22	the	the	DT
cord-000372-wzwpyvll	185	23	eIF4GI	eif4gi	JJ
cord-000372-wzwpyvll	185	24	core	core	NN
cord-000372-wzwpyvll	185	25	(	(	-LRB-
cord-000372-wzwpyvll	185	26	Figure	figure	NN
cord-000372-wzwpyvll	185	27	3	3	CD
cord-000372-wzwpyvll	185	28	)	)	-RRB-
cord-000372-wzwpyvll	186	1	[	[	-LRB-
cord-000372-wzwpyvll	186	2	103	103	CD
cord-000372-wzwpyvll	186	3	,	,	,
cord-000372-wzwpyvll	186	4	104	104	CD
cord-000372-wzwpyvll	186	5	]	]	-RRB-
cord-000372-wzwpyvll	186	6	.	.	.
cord-000372-wzwpyvll	187	1	In	in	IN
cord-000372-wzwpyvll	187	2	contrast	contrast	NN
cord-000372-wzwpyvll	187	3	,	,	,
cord-000372-wzwpyvll	187	4	eIF4GII	eif4gii	NN
cord-000372-wzwpyvll	187	5	is	be	VBZ
cord-000372-wzwpyvll	187	6	degraded	degrade	VBN
cord-000372-wzwpyvll	187	7	during	during	IN
cord-000372-wzwpyvll	187	8	apoptosis	apoptosis	NN
cord-000372-wzwpyvll	187	9	with	with	IN
cord-000372-wzwpyvll	187	10	a	a	DT
cord-000372-wzwpyvll	187	11	delayed	delay	VBN
cord-000372-wzwpyvll	187	12	kinetics	kinetics	NN
cord-000372-wzwpyvll	187	13	in	in	IN
cord-000372-wzwpyvll	187	14	relation	relation	NN
cord-000372-wzwpyvll	187	15	to	to	IN
cord-000372-wzwpyvll	187	16	eIF4GI	eif4gi	NN
cord-000372-wzwpyvll	187	17	proteolysis	proteolysis	NN
cord-000372-wzwpyvll	187	18	,	,	,
cord-000372-wzwpyvll	187	19	correlating	correlate	VBG
cord-000372-wzwpyvll	187	20	with	with	IN
cord-000372-wzwpyvll	187	21	the	the	DT
cord-000372-wzwpyvll	187	22	shutoff	shutoff	NN
cord-000372-wzwpyvll	187	23	of	of	IN
cord-000372-wzwpyvll	187	24	the	the	DT
cord-000372-wzwpyvll	187	25	protein	protein	NN
cord-000372-wzwpyvll	187	26	synthesis	synthesis	NN
cord-000372-wzwpyvll	187	27	[	[	-LRB-
cord-000372-wzwpyvll	187	28	104	104	CD
cord-000372-wzwpyvll	187	29	]	]	-RRB-
cord-000372-wzwpyvll	187	30	.	.	.
cord-000372-wzwpyvll	188	1	Furthermore	furthermore	RB
cord-000372-wzwpyvll	188	2	,	,	,
cord-000372-wzwpyvll	188	3	many	many	JJ
cord-000372-wzwpyvll	188	4	eIF4GI	eif4gi	CD
cord-000372-wzwpyvll	188	5	isoforms	isoform	NNS
cord-000372-wzwpyvll	188	6	have	have	VBP
cord-000372-wzwpyvll	188	7	been	be	VBN
cord-000372-wzwpyvll	188	8	detected	detect	VBN
cord-000372-wzwpyvll	188	9	in	in	IN
cord-000372-wzwpyvll	188	10	HeLa	HeLa	NNP
cord-000372-wzwpyvll	188	11	cells	cell	NNS
cord-000372-wzwpyvll	188	12	and	and	CC
cord-000372-wzwpyvll	188	13	these	these	DT
cord-000372-wzwpyvll	188	14	are	be	VBP
cord-000372-wzwpyvll	188	15	synthesized	synthesize	VBN
cord-000372-wzwpyvll	188	16	from	from	IN
cord-000372-wzwpyvll	188	17	several	several	JJ
cord-000372-wzwpyvll	188	18	distinct	distinct	JJ
cord-000372-wzwpyvll	188	19	mRNAs	mRNAs	NNPS
cord-000372-wzwpyvll	188	20	via	via	IN
cord-000372-wzwpyvll	188	21	alternative	alternative	JJ
cord-000372-wzwpyvll	188	22	promoter	promoter	NN
cord-000372-wzwpyvll	188	23	usage	usage	NN
cord-000372-wzwpyvll	188	24	and	and	CC
cord-000372-wzwpyvll	188	25	alternative	alternative	JJ
cord-000372-wzwpyvll	188	26	splicing	splicing	NN
cord-000372-wzwpyvll	188	27	[	[	-LRB-
cord-000372-wzwpyvll	188	28	105	105	CD
cord-000372-wzwpyvll	188	29	]	]	-RRB-
cord-000372-wzwpyvll	188	30	.	.	.
cord-000372-wzwpyvll	189	1	The	the	DT
cord-000372-wzwpyvll	189	2	largest	large	JJS
cord-000372-wzwpyvll	189	3	is	be	VBZ
cord-000372-wzwpyvll	189	4	the	the	DT
cord-000372-wzwpyvll	189	5	eIF4GI	eif4gi	RB
cord-000372-wzwpyvll	189	6	-	-	HYPH
cord-000372-wzwpyvll	189	7	a	a	DT
cord-000372-wzwpyvll	189	8	isoform	isoform	NN
cord-000372-wzwpyvll	189	9	,	,	,
cord-000372-wzwpyvll	189	10	which	which	WDT
cord-000372-wzwpyvll	189	11	contains	contain	VBZ
cord-000372-wzwpyvll	189	12	1,600	1,600	CD
cord-000372-wzwpyvll	189	13	residues	residue	NNS
cord-000372-wzwpyvll	189	14	,	,	,
cord-000372-wzwpyvll	189	15	while	while	IN
cord-000372-wzwpyvll	189	16	the	the	DT
cord-000372-wzwpyvll	189	17	eIF4GI	eif4gi	NN
cord-000372-wzwpyvll	189	18	-	-	HYPH
cord-000372-wzwpyvll	189	19	b	b	NN
cord-000372-wzwpyvll	189	20	,	,	,
cord-000372-wzwpyvll	189	21	-c	-c	:
cord-000372-wzwpyvll	189	22	,	,	,
cord-000372-wzwpyvll	189	23	-d	-d	NNP
cord-000372-wzwpyvll	189	24	,	,	,
cord-000372-wzwpyvll	189	25	ande	ande	NNP
cord-000372-wzwpyvll	189	26	are	be	VBP
cord-000372-wzwpyvll	189	27	shorter	short	JJR
cord-000372-wzwpyvll	189	28	variants	variant	NNS
cord-000372-wzwpyvll	189	29	[	[	-LRB-
cord-000372-wzwpyvll	189	30	106	106	CD
cord-000372-wzwpyvll	189	31	]	]	-RRB-
cord-000372-wzwpyvll	189	32	.	.	.
cord-000372-wzwpyvll	190	1	It	-PRON-	PRP
cord-000372-wzwpyvll	190	2	has	have	VBZ
cord-000372-wzwpyvll	190	3	been	be	VBN
cord-000372-wzwpyvll	190	4	described	describe	VBN
cord-000372-wzwpyvll	190	5	that	that	IN
cord-000372-wzwpyvll	190	6	the	the	DT
cord-000372-wzwpyvll	190	7	longer	long	JJR
cord-000372-wzwpyvll	190	8	isoforms	isoform	NNS
cord-000372-wzwpyvll	190	9	are	be	VBP
cord-000372-wzwpyvll	190	10	more	more	RBR
cord-000372-wzwpyvll	190	11	active	active	JJ
cord-000372-wzwpyvll	190	12	in	in	IN
cord-000372-wzwpyvll	190	13	translation	translation	NN
cord-000372-wzwpyvll	190	14	initiation	initiation	NN
cord-000372-wzwpyvll	190	15	,	,	,
cord-000372-wzwpyvll	190	16	most	most	RBS
cord-000372-wzwpyvll	190	17	probably	probably	RB
cord-000372-wzwpyvll	190	18	because	because	IN
cord-000372-wzwpyvll	190	19	they	-PRON-	PRP
cord-000372-wzwpyvll	190	20	contain	contain	VBP
cord-000372-wzwpyvll	190	21	the	the	DT
cord-000372-wzwpyvll	190	22	PABP	PABP	NNP
cord-000372-wzwpyvll	190	23	-	-	HYPH
cord-000372-wzwpyvll	190	24	binding	bind	VBG
cord-000372-wzwpyvll	190	25	site	site	NN
cord-000372-wzwpyvll	190	26	[	[	-LRB-
cord-000372-wzwpyvll	190	27	107	107	CD
cord-000372-wzwpyvll	190	28	]	]	-RRB-
cord-000372-wzwpyvll	190	29	.	.	.
cord-000372-wzwpyvll	191	1	PV	pv	NN
cord-000372-wzwpyvll	191	2	results	result	VBZ
cord-000372-wzwpyvll	191	3	in	in	IN
cord-000372-wzwpyvll	191	4	a	a	DT
cord-000372-wzwpyvll	191	5	rapid	rapid	JJ
cord-000372-wzwpyvll	191	6	shutoff	shutoff	NN
cord-000372-wzwpyvll	191	7	of	of	IN
cord-000372-wzwpyvll	191	8	host	host	NN
cord-000372-wzwpyvll	191	9	-	-	HYPH
cord-000372-wzwpyvll	191	10	cell	cell	NN
cord-000372-wzwpyvll	191	11	protein	protein	NN
cord-000372-wzwpyvll	191	12	synthesis	synthesis	NN
cord-000372-wzwpyvll	191	13	,	,	,
cord-000372-wzwpyvll	191	14	whereas	whereas	IN
cord-000372-wzwpyvll	191	15	viral	viral	JJ
cord-000372-wzwpyvll	191	16	mRNA	mRNA	NNP
cord-000372-wzwpyvll	191	17	translation	translation	NN
cord-000372-wzwpyvll	191	18	takes	take	VBZ
cord-000372-wzwpyvll	191	19	place	place	NN
cord-000372-wzwpyvll	191	20	efficiently	efficiently	RB
cord-000372-wzwpyvll	191	21	[	[	-LRB-
cord-000372-wzwpyvll	191	22	108	108	CD
cord-000372-wzwpyvll	191	23	]	]	-RRB-
cord-000372-wzwpyvll	191	24	.	.	.
cord-000372-wzwpyvll	192	1	It	-PRON-	PRP
cord-000372-wzwpyvll	192	2	was	be	VBD
cord-000372-wzwpyvll	192	3	initially	initially	RB
cord-000372-wzwpyvll	192	4	observed	observe	VBN
cord-000372-wzwpyvll	192	5	that	that	IN
cord-000372-wzwpyvll	192	6	the	the	DT
cord-000372-wzwpyvll	192	7	inhibition	inhibition	NN
cord-000372-wzwpyvll	192	8	of	of	IN
cord-000372-wzwpyvll	192	9	host	host	NN
cord-000372-wzwpyvll	192	10	-	-	HYPH
cord-000372-wzwpyvll	192	11	cell	cell	NN
cord-000372-wzwpyvll	192	12	translation	translation	NN
cord-000372-wzwpyvll	192	13	in	in	IN
cord-000372-wzwpyvll	192	14	PV	pv	NN
cord-000372-wzwpyvll	192	15	-	-	HYPH
cord-000372-wzwpyvll	192	16	infected	infect	VBN
cord-000372-wzwpyvll	192	17	cells	cell	NNS
cord-000372-wzwpyvll	192	18	correlated	correlate	VBN
cord-000372-wzwpyvll	192	19	with	with	IN
cord-000372-wzwpyvll	192	20	the	the	DT
cord-000372-wzwpyvll	192	21	proteolysis	proteolysis	NN
cord-000372-wzwpyvll	192	22	of	of	IN
cord-000372-wzwpyvll	192	23	a	a	DT
cord-000372-wzwpyvll	192	24	component	component	NN
cord-000372-wzwpyvll	192	25	of	of	IN
cord-000372-wzwpyvll	192	26	the	the	DT
cord-000372-wzwpyvll	192	27	eIF4F	eif4f	CD
cord-000372-wzwpyvll	192	28	complex	complex	NN
cord-000372-wzwpyvll	192	29	with	with	IN
cord-000372-wzwpyvll	192	30	a	a	DT
cord-000372-wzwpyvll	192	31	molecular	molecular	JJ
cord-000372-wzwpyvll	192	32	mass	mass	NN
cord-000372-wzwpyvll	192	33	of	of	IN
cord-000372-wzwpyvll	192	34	about	about	IN
cord-000372-wzwpyvll	192	35	220	220	CD
cord-000372-wzwpyvll	192	36	kDa	kDa	NNS
cord-000372-wzwpyvll	192	37	(	(	-LRB-
cord-000372-wzwpyvll	192	38	later	later	RB
cord-000372-wzwpyvll	192	39	identified	identify	VBN
cord-000372-wzwpyvll	192	40	as	as	IN
cord-000372-wzwpyvll	192	41	eIF4	eIF4	NNP
cord-000372-wzwpyvll	192	42	G	G	NNP
cord-000372-wzwpyvll	192	43	)	)	-RRB-
cord-000372-wzwpyvll	192	44	[	[	-LRB-
cord-000372-wzwpyvll	192	45	39	39	CD
cord-000372-wzwpyvll	192	46	,	,	,
cord-000372-wzwpyvll	192	47	109	109	CD
cord-000372-wzwpyvll	192	48	]	]	-RRB-
cord-000372-wzwpyvll	192	49	.	.	.
cord-000372-wzwpyvll	193	1	This	this	DT
cord-000372-wzwpyvll	193	2	cleavage	cleavage	NN
cord-000372-wzwpyvll	193	3	is	be	VBZ
cord-000372-wzwpyvll	193	4	exerted	exert	VBN
cord-000372-wzwpyvll	193	5	by	by	IN
cord-000372-wzwpyvll	193	6	2A	2a	CD
cord-000372-wzwpyvll	193	7	pro	pro	NNP
cord-000372-wzwpyvll	193	8	and	and	CC
cord-000372-wzwpyvll	193	9	can	can	MD
cord-000372-wzwpyvll	193	10	be	be	VB
cord-000372-wzwpyvll	193	11	prevented	prevent	VBN
cord-000372-wzwpyvll	193	12	by	by	IN
cord-000372-wzwpyvll	193	13	both	both	DT
cord-000372-wzwpyvll	193	14	insertion	insertion	NN
cord-000372-wzwpyvll	193	15	of	of	IN
cord-000372-wzwpyvll	193	16	mutations	mutation	NNS
cord-000372-wzwpyvll	193	17	that	that	WDT
cord-000372-wzwpyvll	193	18	abolish	abolish	VBP
cord-000372-wzwpyvll	193	19	the	the	DT
cord-000372-wzwpyvll	193	20	protease	protease	NN
cord-000372-wzwpyvll	193	21	activity	activity	NN
cord-000372-wzwpyvll	193	22	and	and	CC
cord-000372-wzwpyvll	193	23	addition	addition	NN
cord-000372-wzwpyvll	193	24	of	of	IN
cord-000372-wzwpyvll	193	25	2A	2a	CD
cord-000372-wzwpyvll	193	26	inhibitors	inhibitor	NNS
cord-000372-wzwpyvll	193	27	[	[	-LRB-
cord-000372-wzwpyvll	193	28	76	76	CD
cord-000372-wzwpyvll	193	29	,	,	,
cord-000372-wzwpyvll	193	30	110	110	CD
cord-000372-wzwpyvll	193	31	,	,	,
cord-000372-wzwpyvll	193	32	111	111	CD
cord-000372-wzwpyvll	193	33	]	]	-RRB-
cord-000372-wzwpyvll	193	34	.	.	.
cord-000372-wzwpyvll	194	1	Interestingly	interestingly	RB
cord-000372-wzwpyvll	194	2	,	,	,
cord-000372-wzwpyvll	194	3	this	this	DT
cord-000372-wzwpyvll	194	4	proteolysis	proteolysis	NN
cord-000372-wzwpyvll	194	5	is	be	VBZ
cord-000372-wzwpyvll	194	6	more	more	RBR
cord-000372-wzwpyvll	194	7	effective	effective	JJ
cord-000372-wzwpyvll	194	8	when	when	WRB
cord-000372-wzwpyvll	194	9	eIF4E	eif4e	CD
cord-000372-wzwpyvll	194	10	is	be	VBZ
cord-000372-wzwpyvll	194	11	interacting	interact	VBG
cord-000372-wzwpyvll	194	12	with	with	IN
cord-000372-wzwpyvll	194	13	eIF4	eIF4	NNP
cord-000372-wzwpyvll	194	14	G	G	NNP
cord-000372-wzwpyvll	194	15	,	,	,
cord-000372-wzwpyvll	194	16	suggesting	suggest	VBG
cord-000372-wzwpyvll	194	17	that	that	IN
cord-000372-wzwpyvll	194	18	PV	PV	NNP
cord-000372-wzwpyvll	194	19	2A	2a	NN
cord-000372-wzwpyvll	194	20	pro	pro	JJ
cord-000372-wzwpyvll	194	21	preferentially	preferentially	RB
cord-000372-wzwpyvll	194	22	acts	act	VBZ
cord-000372-wzwpyvll	194	23	on	on	IN
cord-000372-wzwpyvll	194	24	the	the	DT
cord-000372-wzwpyvll	194	25	eIF4	eIF4	NNP
cord-000372-wzwpyvll	194	26	G	g	NN
cord-000372-wzwpyvll	194	27	pool	pool	NN
cord-000372-wzwpyvll	194	28	involved	involve	VBN
cord-000372-wzwpyvll	194	29	in	in	IN
cord-000372-wzwpyvll	194	30	translation	translation	NN
cord-000372-wzwpyvll	194	31	[	[	-LRB-
cord-000372-wzwpyvll	194	32	112	112	CD
cord-000372-wzwpyvll	194	33	]	]	-RRB-
cord-000372-wzwpyvll	194	34	.	.	.
cord-000372-wzwpyvll	195	1	Cleavage	cleavage	NN
cord-000372-wzwpyvll	195	2	of	of	IN
cord-000372-wzwpyvll	195	3	eIF4GI	eif4gi	DT
cord-000372-wzwpyvll	195	4	also	also	RB
cord-000372-wzwpyvll	195	5	occurs	occur	VBZ
cord-000372-wzwpyvll	195	6	in	in	IN
cord-000372-wzwpyvll	195	7	cells	cell	NNS
cord-000372-wzwpyvll	195	8	infected	infect	VBN
cord-000372-wzwpyvll	195	9	with	with	IN
cord-000372-wzwpyvll	195	10	other	other	JJ
cord-000372-wzwpyvll	195	11	picornaviruses	picornavirus	NNS
cord-000372-wzwpyvll	195	12	such	such	JJ
cord-000372-wzwpyvll	195	13	as	as	IN
cord-000372-wzwpyvll	195	14	HRV	HRV	NNP
cord-000372-wzwpyvll	195	15	,	,	,
cord-000372-wzwpyvll	195	16	coxsackievirus	coxsackievirus	NNP
cord-000372-wzwpyvll	195	17	,	,	,
cord-000372-wzwpyvll	195	18	and	and	CC
cord-000372-wzwpyvll	195	19	FMDV	FMDV	NNP
cord-000372-wzwpyvll	195	20	[	[	-LRB-
cord-000372-wzwpyvll	195	21	48	48	CD
cord-000372-wzwpyvll	195	22	,	,	,
cord-000372-wzwpyvll	195	23	113	113	CD
cord-000372-wzwpyvll	195	24	,	,	,
cord-000372-wzwpyvll	195	25	114	114	CD
cord-000372-wzwpyvll	195	26	]	]	-RRB-
cord-000372-wzwpyvll	195	27	.	.	.
cord-000372-wzwpyvll	196	1	Interestingly	interestingly	RB
cord-000372-wzwpyvll	196	2	,	,	,
cord-000372-wzwpyvll	196	3	2A	2a	CD
cord-000372-wzwpyvll	196	4	pro	pro	NN
cord-000372-wzwpyvll	196	5	from	from	IN
cord-000372-wzwpyvll	196	6	PV	PV	NNP
cord-000372-wzwpyvll	196	7	,	,	,
cord-000372-wzwpyvll	196	8	HRV	HRV	NNP
cord-000372-wzwpyvll	196	9	,	,	,
cord-000372-wzwpyvll	196	10	and	and	CC
cord-000372-wzwpyvll	196	11	coxsackieviruses	coxsackievirus	NNS
cord-000372-wzwpyvll	196	12	cleave	cleave	VBP
cord-000372-wzwpyvll	196	13	eIF4GI	eIF4GI	NNS
cord-000372-wzwpyvll	196	14	at	at	IN
cord-000372-wzwpyvll	196	15	positions	position	NNS
cord-000372-wzwpyvll	196	16	681/682	681/682	NN
cord-000372-wzwpyvll	196	17	(	(	-LRB-
cord-000372-wzwpyvll	196	18	Figure	figure	NN
cord-000372-wzwpyvll	196	19	3	3	CD
cord-000372-wzwpyvll	196	20	)	)	-RRB-
cord-000372-wzwpyvll	196	21	,	,	,
cord-000372-wzwpyvll	196	22	suggesting	suggest	VBG
cord-000372-wzwpyvll	196	23	the	the	DT
cord-000372-wzwpyvll	196	24	conservation	conservation	NN
cord-000372-wzwpyvll	196	25	of	of	IN
cord-000372-wzwpyvll	196	26	the	the	DT
cord-000372-wzwpyvll	196	27	specificity	specificity	NN
cord-000372-wzwpyvll	196	28	of	of	IN
cord-000372-wzwpyvll	196	29	enterovirus	enterovirus	NN
cord-000372-wzwpyvll	196	30	2A	2a	CD
cord-000372-wzwpyvll	196	31	proteases	protease	NNS
cord-000372-wzwpyvll	196	32	for	for	IN
cord-000372-wzwpyvll	196	33	the	the	DT
cord-000372-wzwpyvll	196	34	substrate	substrate	JJ
cord-000372-wzwpyvll	196	35	determinants	determinant	NNS
cord-000372-wzwpyvll	196	36	present	present	JJ
cord-000372-wzwpyvll	196	37	in	in	IN
cord-000372-wzwpyvll	196	38	eIF4GI	eIF4GI	NNS
cord-000372-wzwpyvll	196	39	[	[	-LRB-
cord-000372-wzwpyvll	196	40	114	114	CD
cord-000372-wzwpyvll	196	41	,	,	,
cord-000372-wzwpyvll	196	42	115	115	CD
cord-000372-wzwpyvll	196	43	]	]	-RRB-
cord-000372-wzwpyvll	196	44	.	.	.
cord-000372-wzwpyvll	197	1	Cleavage	cleavage	NN
cord-000372-wzwpyvll	197	2	at	at	IN
cord-000372-wzwpyvll	197	3	position	position	NN
cord-000372-wzwpyvll	197	4	681/682	681/682	NN
cord-000372-wzwpyvll	197	5	separates	separate	VBZ
cord-000372-wzwpyvll	197	6	eIF4E	eif4e	CD
cord-000372-wzwpyvll	197	7	-	-	:
cord-000372-wzwpyvll	197	8	and	and	CC
cord-000372-wzwpyvll	197	9	eIF3binding	eif3binding	NN
cord-000372-wzwpyvll	197	10	sites	site	NNS
cord-000372-wzwpyvll	197	11	of	of	IN
cord-000372-wzwpyvll	197	12	eIF4GI	eIF4GI	NNS
cord-000372-wzwpyvll	197	13	,	,	,
cord-000372-wzwpyvll	197	14	contained	contain	VBN
cord-000372-wzwpyvll	197	15	in	in	IN
cord-000372-wzwpyvll	197	16	N	n	CD
cord-000372-wzwpyvll	197	17	-	-	HYPH
cord-000372-wzwpyvll	197	18	terminal	terminal	NN
cord-000372-wzwpyvll	197	19	and	and	CC
cord-000372-wzwpyvll	197	20	Cterminal	cterminal	JJ
cord-000372-wzwpyvll	197	21	fragments	fragment	NNS
cord-000372-wzwpyvll	197	22	respectively	respectively	RB
cord-000372-wzwpyvll	197	23	,	,	,
cord-000372-wzwpyvll	197	24	thus	thus	RB
cord-000372-wzwpyvll	197	25	decoupling	decouple	VBG
cord-000372-wzwpyvll	197	26	mRNA	mRNA	NNP
cord-000372-wzwpyvll	197	27	and	and	CC
cord-000372-wzwpyvll	197	28	ribosome	ribosome	NN
cord-000372-wzwpyvll	197	29	recruiting	recruiting	NN
cord-000372-wzwpyvll	197	30	activities	activity	NNS
cord-000372-wzwpyvll	197	31	.	.	.
cord-000372-wzwpyvll	198	1	The	the	DT
cord-000372-wzwpyvll	198	2	PV	PV	NNP
cord-000372-wzwpyvll	198	3	2A	2a	NN
cord-000372-wzwpyvll	198	4	pro	pro	NNP
cord-000372-wzwpyvll	198	5	cleaves	cleave	VBZ
cord-000372-wzwpyvll	198	6	eIF4GI	eIF4GI	VBZ
cord-000372-wzwpyvll	198	7	directly	directly	RB
cord-000372-wzwpyvll	198	8	and	and	CC
cord-000372-wzwpyvll	198	9	does	do	VBZ
cord-000372-wzwpyvll	198	10	not	not	RB
cord-000372-wzwpyvll	198	11	require	require	VB
cord-000372-wzwpyvll	198	12	any	any	DT
cord-000372-wzwpyvll	198	13	additional	additional	JJ
cord-000372-wzwpyvll	198	14	proteins	protein	NNS
cord-000372-wzwpyvll	198	15	for	for	IN
cord-000372-wzwpyvll	198	16	this	this	DT
cord-000372-wzwpyvll	198	17	process	process	NN
cord-000372-wzwpyvll	198	18	to	to	TO
cord-000372-wzwpyvll	198	19	occur	occur	VB
cord-000372-wzwpyvll	198	20	[	[	-LRB-
cord-000372-wzwpyvll	198	21	116	116	CD
cord-000372-wzwpyvll	198	22	,	,	,
cord-000372-wzwpyvll	198	23	117	117	CD
cord-000372-wzwpyvll	198	24	]	]	-RRB-
cord-000372-wzwpyvll	198	25	.	.	.
cord-000372-wzwpyvll	199	1	However	however	RB
cord-000372-wzwpyvll	199	2	,	,	,
cord-000372-wzwpyvll	199	3	the	the	DT
cord-000372-wzwpyvll	199	4	fact	fact	NN
cord-000372-wzwpyvll	199	5	that	that	IN
cord-000372-wzwpyvll	199	6	PV	PV	NNP
cord-000372-wzwpyvll	199	7	2A	2a	NN
cord-000372-wzwpyvll	199	8	pro	pro	NNP
cord-000372-wzwpyvll	199	9	is	be	VBZ
cord-000372-wzwpyvll	199	10	not	not	RB
cord-000372-wzwpyvll	199	11	copurified	copurifie	VBN
cord-000372-wzwpyvll	199	12	with	with	IN
cord-000372-wzwpyvll	199	13	eIF4GI	eif4gi	DT
cord-000372-wzwpyvll	199	14	fragments	fragment	NNS
cord-000372-wzwpyvll	199	15	from	from	IN
cord-000372-wzwpyvll	199	16	PV	pv	NN
cord-000372-wzwpyvll	199	17	-	-	HYPH
cord-000372-wzwpyvll	199	18	infected	infect	VBN
cord-000372-wzwpyvll	199	19	cell	cell	NN
cord-000372-wzwpyvll	199	20	extracts	extract	NNS
cord-000372-wzwpyvll	199	21	suggest	suggest	VBP
cord-000372-wzwpyvll	199	22	that	that	IN
cord-000372-wzwpyvll	199	23	2A	2a	CD
cord-000372-wzwpyvll	199	24	pro	pro	NNP
cord-000372-wzwpyvll	199	25	induced	induce	VBD
cord-000372-wzwpyvll	199	26	the	the	DT
cord-000372-wzwpyvll	199	27	activation	activation	NN
cord-000372-wzwpyvll	199	28	of	of	IN
cord-000372-wzwpyvll	199	29	a	a	DT
cord-000372-wzwpyvll	199	30	host	host	NN
cord-000372-wzwpyvll	199	31	protease	protease	NN
cord-000372-wzwpyvll	199	32	,	,	,
cord-000372-wzwpyvll	199	33	which	which	WDT
cord-000372-wzwpyvll	199	34	in	in	IN
cord-000372-wzwpyvll	199	35	turn	turn	NN
cord-000372-wzwpyvll	199	36	cleaves	cleave	VBZ
cord-000372-wzwpyvll	199	37	eIF4	eif4	IN
cord-000372-wzwpyvll	199	38	G	g	NN
cord-000372-wzwpyvll	199	39	during	during	IN
cord-000372-wzwpyvll	199	40	PV	pv	NN
cord-000372-wzwpyvll	199	41	infection	infection	NN
cord-000372-wzwpyvll	199	42	[	[	-LRB-
cord-000372-wzwpyvll	199	43	112	112	CD
cord-000372-wzwpyvll	199	44	]	]	-RRB-
cord-000372-wzwpyvll	199	45	.	.	.
cord-000372-wzwpyvll	200	1	In	in	IN
cord-000372-wzwpyvll	200	2	addition	addition	NN
cord-000372-wzwpyvll	200	3	,	,	,
cord-000372-wzwpyvll	200	4	it	-PRON-	PRP
cord-000372-wzwpyvll	200	5	has	have	VBZ
cord-000372-wzwpyvll	200	6	been	be	VBN
cord-000372-wzwpyvll	200	7	proposed	propose	VBN
cord-000372-wzwpyvll	200	8	that	that	IN
cord-000372-wzwpyvll	200	9	eIF3	eIF3	NNP
cord-000372-wzwpyvll	200	10	and	and	CC
cord-000372-wzwpyvll	200	11	an	an	DT
cord-000372-wzwpyvll	200	12	unknown	unknown	JJ
cord-000372-wzwpyvll	200	13	host	host	NN
cord-000372-wzwpyvll	200	14	-	-	HYPH
cord-000372-wzwpyvll	200	15	cell	cell	NN
cord-000372-wzwpyvll	200	16	protein	protein	NN
cord-000372-wzwpyvll	200	17	could	could	MD
cord-000372-wzwpyvll	200	18	act	act	VB
cord-000372-wzwpyvll	200	19	as	as	IN
cord-000372-wzwpyvll	200	20	cofactors	cofactor	NNS
cord-000372-wzwpyvll	200	21	for	for	IN
cord-000372-wzwpyvll	200	22	eIF4GI	eif4gi	DT
cord-000372-wzwpyvll	200	23	cleavage	cleavage	NN
cord-000372-wzwpyvll	200	24	by	by	IN
cord-000372-wzwpyvll	200	25	PV	PV	NNP
cord-000372-wzwpyvll	200	26	2A	2a	CD
cord-000372-wzwpyvll	200	27	pro	pro	JJ
cord-000372-wzwpyvll	200	28	[	[	-LRB-
cord-000372-wzwpyvll	200	29	118	118	CD
cord-000372-wzwpyvll	200	30	]	]	-RRB-
cord-000372-wzwpyvll	200	31	.	.	.
cord-000372-wzwpyvll	201	1	In	in	IN
cord-000372-wzwpyvll	201	2	this	this	DT
cord-000372-wzwpyvll	201	3	sense	sense	NN
cord-000372-wzwpyvll	201	4	,	,	,
cord-000372-wzwpyvll	201	5	Zamora	Zamora	NNP
cord-000372-wzwpyvll	201	6	and	and	CC
cord-000372-wzwpyvll	201	7	colleagues	colleague	NNS
cord-000372-wzwpyvll	201	8	suggested	suggest	VBD
cord-000372-wzwpyvll	201	9	that	that	IN
cord-000372-wzwpyvll	201	10	PV	PV	NNP
cord-000372-wzwpyvll	201	11	infection	infection	NN
cord-000372-wzwpyvll	201	12	activates	activate	VBZ
cord-000372-wzwpyvll	201	13	at	at	RB
cord-000372-wzwpyvll	201	14	least	least	RBS
cord-000372-wzwpyvll	201	15	two	two	CD
cord-000372-wzwpyvll	201	16	host	host	NN
cord-000372-wzwpyvll	201	17	-	-	HYPH
cord-000372-wzwpyvll	201	18	cell	cell	NN
cord-000372-wzwpyvll	201	19	proteases	protease	NNS
cord-000372-wzwpyvll	201	20	,	,	,
cord-000372-wzwpyvll	201	21	which	which	WDT
cord-000372-wzwpyvll	201	22	together	together	RB
cord-000372-wzwpyvll	201	23	with	with	IN
cord-000372-wzwpyvll	201	24	PV	PV	NNP
cord-000372-wzwpyvll	201	25	2A	2a	NN
cord-000372-wzwpyvll	201	26	pro	pro	JJ
cord-000372-wzwpyvll	201	27	,	,	,
cord-000372-wzwpyvll	201	28	cleave	cleave	VB
cord-000372-wzwpyvll	201	29	eIF4GI	eif4gi	DT
cord-000372-wzwpyvll	201	30	[	[	-LRB-
cord-000372-wzwpyvll	201	31	119	119	CD
cord-000372-wzwpyvll	201	32	]	]	-RRB-
cord-000372-wzwpyvll	201	33	.	.	.
cord-000372-wzwpyvll	202	1	Nevertheless	nevertheless	RB
cord-000372-wzwpyvll	202	2	,	,	,
cord-000372-wzwpyvll	202	3	no	no	DT
cord-000372-wzwpyvll	202	4	additional	additional	JJ
cord-000372-wzwpyvll	202	5	evidence	evidence	NN
cord-000372-wzwpyvll	202	6	has	have	VBZ
cord-000372-wzwpyvll	202	7	been	be	VBN
cord-000372-wzwpyvll	202	8	put	put	VBN
cord-000372-wzwpyvll	202	9	forward	forward	RB
cord-000372-wzwpyvll	202	10	to	to	TO
cord-000372-wzwpyvll	202	11	support	support	VB
cord-000372-wzwpyvll	202	12	this	this	DT
cord-000372-wzwpyvll	202	13	hypothesis	hypothesis	NN
cord-000372-wzwpyvll	202	14	and	and	CC
cord-000372-wzwpyvll	202	15	the	the	DT
cord-000372-wzwpyvll	202	16	identity	identity	NN
cord-000372-wzwpyvll	202	17	of	of	IN
cord-000372-wzwpyvll	202	18	these	these	DT
cord-000372-wzwpyvll	202	19	host	host	NN
cord-000372-wzwpyvll	202	20	proteases	protease	NNS
cord-000372-wzwpyvll	202	21	has	have	VBZ
cord-000372-wzwpyvll	202	22	not	not	RB
cord-000372-wzwpyvll	202	23	yet	yet	RB
cord-000372-wzwpyvll	202	24	been	be	VBN
cord-000372-wzwpyvll	202	25	determined	determine	VBN
cord-000372-wzwpyvll	202	26	.	.	.
cord-000372-wzwpyvll	203	1	Many	many	JJ
cord-000372-wzwpyvll	203	2	reports	report	NNS
cord-000372-wzwpyvll	203	3	have	have	VBP
cord-000372-wzwpyvll	203	4	demonstrated	demonstrate	VBN
cord-000372-wzwpyvll	203	5	that	that	IN
cord-000372-wzwpyvll	203	6	the	the	DT
cord-000372-wzwpyvll	203	7	kinetics	kinetic	NNS
cord-000372-wzwpyvll	203	8	of	of	IN
cord-000372-wzwpyvll	203	9	protein	protein	NN
cord-000372-wzwpyvll	203	10	synthesis	synthesis	NN
cord-000372-wzwpyvll	203	11	shutoff	shutoff	NN
cord-000372-wzwpyvll	203	12	and	and	CC
cord-000372-wzwpyvll	203	13	eIF4GI	eif4gi	NN
cord-000372-wzwpyvll	203	14	cleavage	cleavage	NN
cord-000372-wzwpyvll	203	15	are	be	VBP
cord-000372-wzwpyvll	203	16	not	not	RB
cord-000372-wzwpyvll	203	17	correlated	correlate	VBN
cord-000372-wzwpyvll	203	18	in	in	IN
cord-000372-wzwpyvll	203	19	PV	pv	NN
cord-000372-wzwpyvll	203	20	-	-	HYPH
cord-000372-wzwpyvll	203	21	infected	infect	VBN
cord-000372-wzwpyvll	203	22	cells	cell	NNS
cord-000372-wzwpyvll	203	23	[	[	-LRB-
cord-000372-wzwpyvll	203	24	120	120	CD
cord-000372-wzwpyvll	203	25	]	]	-RRB-
cord-000372-wzwpyvll	203	26	[	[	-LRB-
cord-000372-wzwpyvll	203	27	121	121	CD
cord-000372-wzwpyvll	203	28	]	]	-RRB-
cord-000372-wzwpyvll	203	29	[	[	-LRB-
cord-000372-wzwpyvll	203	30	122	122	CD
cord-000372-wzwpyvll	203	31	]	]	-RRB-
cord-000372-wzwpyvll	203	32	.	.	.
cord-000372-wzwpyvll	204	1	These	these	DT
cord-000372-wzwpyvll	204	2	data	datum	NNS
cord-000372-wzwpyvll	204	3	clearly	clearly	RB
cord-000372-wzwpyvll	204	4	indicate	indicate	VBP
cord-000372-wzwpyvll	204	5	that	that	IN
cord-000372-wzwpyvll	204	6	additional	additional	JJ
cord-000372-wzwpyvll	204	7	translation	translation	NN
cord-000372-wzwpyvll	204	8	factors	factor	NNS
cord-000372-wzwpyvll	204	9	may	may	MD
cord-000372-wzwpyvll	204	10	be	be	VB
cord-000372-wzwpyvll	204	11	cleaved	cleave	VBN
cord-000372-wzwpyvll	204	12	to	to	TO
cord-000372-wzwpyvll	204	13	achieve	achieve	VB
cord-000372-wzwpyvll	204	14	an	an	DT
cord-000372-wzwpyvll	204	15	efficient	efficient	JJ
cord-000372-wzwpyvll	204	16	inhibition	inhibition	NN
cord-000372-wzwpyvll	204	17	of	of	IN
cord-000372-wzwpyvll	204	18	cellular	cellular	JJ
cord-000372-wzwpyvll	204	19	mRNA	mRNA	NNP
cord-000372-wzwpyvll	204	20	translation	translation	NN
cord-000372-wzwpyvll	204	21	.	.	.
cord-000372-wzwpyvll	205	1	In	in	IN
cord-000372-wzwpyvll	205	2	this	this	DT
cord-000372-wzwpyvll	205	3	regard	regard	NN
cord-000372-wzwpyvll	205	4	,	,	,
cord-000372-wzwpyvll	205	5	additional	additional	JJ
cord-000372-wzwpyvll	205	6	reports	report	NNS
cord-000372-wzwpyvll	205	7	showed	show	VBD
cord-000372-wzwpyvll	205	8	that	that	IN
cord-000372-wzwpyvll	205	9	eIF4GII	eif4gii	NN
cord-000372-wzwpyvll	205	10	is	be	VBZ
cord-000372-wzwpyvll	205	11	also	also	RB
cord-000372-wzwpyvll	205	12	proteolyzed	proteolyze	VBN
cord-000372-wzwpyvll	205	13	by	by	IN
cord-000372-wzwpyvll	205	14	2A	2a	CD
cord-000372-wzwpyvll	205	15	pro	pro	NN
cord-000372-wzwpyvll	205	16	during	during	IN
cord-000372-wzwpyvll	205	17	PV	PV	NNP
cord-000372-wzwpyvll	205	18	and	and	CC
cord-000372-wzwpyvll	205	19	HRV	HRV	NNP
cord-000372-wzwpyvll	205	20	infections	infection	NNS
cord-000372-wzwpyvll	205	21	and	and	CC
cord-000372-wzwpyvll	205	22	that	that	IN
cord-000372-wzwpyvll	205	23	this	this	DT
cord-000372-wzwpyvll	205	24	cleavage	cleavage	NN
cord-000372-wzwpyvll	205	25	is	be	VBZ
cord-000372-wzwpyvll	205	26	exerted	exert	VBN
cord-000372-wzwpyvll	205	27	between	between	IN
cord-000372-wzwpyvll	205	28	amino	amino	NN
cord-000372-wzwpyvll	205	29	acids	acid	NNS
cord-000372-wzwpyvll	205	30	699/700	699/700	CD
cord-000372-wzwpyvll	205	31	leading	lead	VBG
cord-000372-wzwpyvll	205	32	to	to	IN
cord-000372-wzwpyvll	205	33	a	a	DT
cord-000372-wzwpyvll	205	34	proteolytic	proteolytic	JJ
cord-000372-wzwpyvll	205	35	pattern	pattern	NN
cord-000372-wzwpyvll	205	36	similar	similar	JJ
cord-000372-wzwpyvll	205	37	to	to	IN
cord-000372-wzwpyvll	205	38	eIF4GI	eIF4GI	NNS
cord-000372-wzwpyvll	205	39	.	.	.
cord-000372-wzwpyvll	206	1	Interestingly	interestingly	RB
cord-000372-wzwpyvll	206	2	,	,	,
cord-000372-wzwpyvll	206	3	eIF4GII	eif4gii	NN
cord-000372-wzwpyvll	206	4	is	be	VBZ
cord-000372-wzwpyvll	206	5	significantly	significantly	RB
cord-000372-wzwpyvll	206	6	more	more	RBR
cord-000372-wzwpyvll	206	7	resistant	resistant	JJ
cord-000372-wzwpyvll	206	8	to	to	IN
cord-000372-wzwpyvll	206	9	2A	2a	CD
cord-000372-wzwpyvll	206	10	pro	pro	JJ
cord-000372-wzwpyvll	206	11	-mediated	-mediated	JJ
cord-000372-wzwpyvll	206	12	cleavage	cleavage	NN
cord-000372-wzwpyvll	206	13	than	than	IN
cord-000372-wzwpyvll	206	14	eIF4GI	eIF4GI	NNS
cord-000372-wzwpyvll	206	15	and	and	CC
cord-000372-wzwpyvll	206	16	the	the	DT
cord-000372-wzwpyvll	206	17	kinetics	kinetic	NNS
cord-000372-wzwpyvll	206	18	of	of	IN
cord-000372-wzwpyvll	206	19	protein	protein	NN
cord-000372-wzwpyvll	206	20	synthesis	synthesis	NN
cord-000372-wzwpyvll	206	21	shutoff	shutoff	NN
cord-000372-wzwpyvll	206	22	close	close	JJ
cord-000372-wzwpyvll	206	23	correlates	correlate	NNS
cord-000372-wzwpyvll	206	24	with	with	IN
cord-000372-wzwpyvll	206	25	eIF4GII	eif4gii	PRP$
cord-000372-wzwpyvll	206	26	cleavage	cleavage	NN
cord-000372-wzwpyvll	206	27	in	in	IN
cord-000372-wzwpyvll	206	28	PV	pv	NN
cord-000372-wzwpyvll	206	29	-	-	:
cord-000372-wzwpyvll	206	30	and	and	CC
cord-000372-wzwpyvll	206	31	RHV	rhv	NN
cord-000372-wzwpyvll	206	32	-	-	HYPH
cord-000372-wzwpyvll	206	33	infected	infect	VBN
cord-000372-wzwpyvll	206	34	cells	cell	NNS
cord-000372-wzwpyvll	206	35	[	[	-LRB-
cord-000372-wzwpyvll	206	36	122	122	CD
cord-000372-wzwpyvll	206	37	,	,	,
cord-000372-wzwpyvll	206	38	123	123	CD
cord-000372-wzwpyvll	206	39	]	]	-RRB-
cord-000372-wzwpyvll	206	40	.	.	.
cord-000372-wzwpyvll	207	1	In	in	IN
cord-000372-wzwpyvll	207	2	those	those	DT
cord-000372-wzwpyvll	207	3	studies	study	NNS
cord-000372-wzwpyvll	207	4	,	,	,
cord-000372-wzwpyvll	207	5	Gradi	Gradi	NNP
cord-000372-wzwpyvll	207	6	and	and	CC
cord-000372-wzwpyvll	207	7	colleagues	colleague	NNS
cord-000372-wzwpyvll	207	8	proposed	propose	VBD
cord-000372-wzwpyvll	207	9	that	that	IN
cord-000372-wzwpyvll	207	10	hydrolysis	hydrolysis	NN
cord-000372-wzwpyvll	207	11	of	of	IN
cord-000372-wzwpyvll	207	12	both	both	DT
cord-000372-wzwpyvll	207	13	eIF4GI	eIF4GI	NNS
cord-000372-wzwpyvll	207	14	and	and	CC
cord-000372-wzwpyvll	207	15	eIF4GII	eif4gii	NN
cord-000372-wzwpyvll	207	16	is	be	VBZ
cord-000372-wzwpyvll	207	17	required	require	VBN
cord-000372-wzwpyvll	207	18	for	for	IN
cord-000372-wzwpyvll	207	19	achieving	achieve	VBG
cord-000372-wzwpyvll	207	20	PV	PV	NNP
cord-000372-wzwpyvll	207	21	-	-	HYPH
cord-000372-wzwpyvll	207	22	and	and	CC
cord-000372-wzwpyvll	207	23	HRV	HRV	NNP
cord-000372-wzwpyvll	207	24	-	-	HYPH
cord-000372-wzwpyvll	207	25	mediated	mediate	VBN
cord-000372-wzwpyvll	207	26	inhibition	inhibition	NN
cord-000372-wzwpyvll	207	27	of	of	IN
cord-000372-wzwpyvll	207	28	host	host	NN
cord-000372-wzwpyvll	207	29	-	-	HYPH
cord-000372-wzwpyvll	207	30	cell	cell	NN
cord-000372-wzwpyvll	207	31	mRNA	mrna	NN
cord-000372-wzwpyvll	207	32	translation	translation	NN
cord-000372-wzwpyvll	207	33	and	and	CC
cord-000372-wzwpyvll	207	34	that	that	IN
cord-000372-wzwpyvll	207	35	the	the	DT
cord-000372-wzwpyvll	207	36	cleavage	cleavage	NN
cord-000372-wzwpyvll	207	37	of	of	IN
cord-000372-wzwpyvll	207	38	eIF4GII	eif4gii	NN
cord-000372-wzwpyvll	207	39	is	be	VBZ
cord-000372-wzwpyvll	207	40	the	the	DT
cord-000372-wzwpyvll	207	41	rate	rate	NN
cord-000372-wzwpyvll	207	42	-	-	HYPH
cord-000372-wzwpyvll	207	43	limiting	limit	VBG
cord-000372-wzwpyvll	207	44	step	step	NN
cord-000372-wzwpyvll	207	45	in	in	IN
cord-000372-wzwpyvll	207	46	the	the	DT
cord-000372-wzwpyvll	207	47	shutoff	shutoff	NN
cord-000372-wzwpyvll	207	48	of	of	IN
cord-000372-wzwpyvll	207	49	host	host	NN
cord-000372-wzwpyvll	207	50	-	-	HYPH
cord-000372-wzwpyvll	207	51	cell	cell	NN
cord-000372-wzwpyvll	207	52	translation	translation	NN
cord-000372-wzwpyvll	207	53	after	after	IN
cord-000372-wzwpyvll	207	54	infection	infection	NN
cord-000372-wzwpyvll	207	55	with	with	IN
cord-000372-wzwpyvll	207	56	those	those	DT
cord-000372-wzwpyvll	207	57	viruses	virus	NNS
cord-000372-wzwpyvll	207	58	[	[	-LRB-
cord-000372-wzwpyvll	207	59	122	122	CD
cord-000372-wzwpyvll	207	60	,	,	,
cord-000372-wzwpyvll	207	61	123	123	CD
cord-000372-wzwpyvll	207	62	]	]	-RRB-
cord-000372-wzwpyvll	207	63	.	.	.
cord-000372-wzwpyvll	208	1	A	a	DT
cord-000372-wzwpyvll	208	2	variety	variety	NN
cord-000372-wzwpyvll	208	3	of	of	IN
cord-000372-wzwpyvll	208	4	approaches	approach	NNS
cord-000372-wzwpyvll	208	5	have	have	VBP
cord-000372-wzwpyvll	208	6	been	be	VBN
cord-000372-wzwpyvll	208	7	devised	devise	VBN
cord-000372-wzwpyvll	208	8	to	to	TO
cord-000372-wzwpyvll	208	9	express	express	VB
cord-000372-wzwpyvll	208	10	PV	PV	NNP
cord-000372-wzwpyvll	208	11	2A	2a	CD
cord-000372-wzwpyvll	208	12	pro	pro	JJ
cord-000372-wzwpyvll	208	13	in	in	IN
cord-000372-wzwpyvll	208	14	order	order	NN
cord-000372-wzwpyvll	208	15	to	to	TO
cord-000372-wzwpyvll	208	16	cleave	cleave	VB
cord-000372-wzwpyvll	208	17	eIF4	eIF4	NNP
cord-000372-wzwpyvll	208	18	G	g	NN
cord-000372-wzwpyvll	208	19	in	in	IN
cord-000372-wzwpyvll	208	20	culture	culture	NN
cord-000372-wzwpyvll	208	21	cells	cell	NNS
cord-000372-wzwpyvll	208	22	or	or	CC
cord-000372-wzwpyvll	208	23	in	in	IN
cord-000372-wzwpyvll	208	24	cellfree	cellfree	NNP
cord-000372-wzwpyvll	208	25	systems	system	NNS
cord-000372-wzwpyvll	208	26	.	.	.
cord-000372-wzwpyvll	209	1	Of	of	IN
cord-000372-wzwpyvll	209	2	these	these	DT
cord-000372-wzwpyvll	209	3	approaches	approach	NNS
cord-000372-wzwpyvll	209	4	,	,	,
cord-000372-wzwpyvll	209	5	the	the	DT
cord-000372-wzwpyvll	209	6	most	most	RBS
cord-000372-wzwpyvll	209	7	straightforward	straightforward	JJ
cord-000372-wzwpyvll	209	8	system	system	NN
cord-000372-wzwpyvll	209	9	has	have	VBZ
cord-000372-wzwpyvll	209	10	been	be	VBN
cord-000372-wzwpyvll	209	11	the	the	DT
cord-000372-wzwpyvll	209	12	addition	addition	NN
cord-000372-wzwpyvll	209	13	of	of	IN
cord-000372-wzwpyvll	209	14	the	the	DT
cord-000372-wzwpyvll	209	15	purified	purify	VBN
cord-000372-wzwpyvll	209	16	PV	PV	NNP
cord-000372-wzwpyvll	209	17	2A	2a	NN
cord-000372-wzwpyvll	209	18	pro	pro	JJ
cord-000372-wzwpyvll	209	19	,	,	,
cord-000372-wzwpyvll	209	20	usually	usually	RB
cord-000372-wzwpyvll	209	21	as	as	IN
cord-000372-wzwpyvll	209	22	a	a	DT
cord-000372-wzwpyvll	209	23	hybrid	hybrid	JJ
cord-000372-wzwpyvll	209	24	protein	protein	NN
cord-000372-wzwpyvll	209	25	such	such	JJ
cord-000372-wzwpyvll	209	26	as	as	IN
cord-000372-wzwpyvll	209	27	MBP-2A	MBP-2A	NNP
cord-000372-wzwpyvll	209	28	pro	pro	NNP
cord-000372-wzwpyvll	209	29	,	,	,
cord-000372-wzwpyvll	209	30	to	to	IN
cord-000372-wzwpyvll	209	31	cellfree	cellfree	NNP
cord-000372-wzwpyvll	209	32	systems	system	NNS
cord-000372-wzwpyvll	209	33	such	such	JJ
cord-000372-wzwpyvll	209	34	as	as	IN
cord-000372-wzwpyvll	209	35	rabbit	rabbit	NN
cord-000372-wzwpyvll	209	36	reticulocyte	reticulocyte	NNP
cord-000372-wzwpyvll	209	37	lysates	lysates	NNP
cord-000372-wzwpyvll	209	38	(	(	-LRB-
cord-000372-wzwpyvll	209	39	RRLs	RRLs	NNP
cord-000372-wzwpyvll	209	40	)	)	-RRB-
cord-000372-wzwpyvll	209	41	,	,	,
cord-000372-wzwpyvll	209	42	HeLa	HeLa	NNP
cord-000372-wzwpyvll	209	43	and	and	CC
cord-000372-wzwpyvll	209	44	Krebs-2	Krebs-2	NNP
cord-000372-wzwpyvll	209	45	extracts	extract	VBZ
cord-000372-wzwpyvll	209	46	[	[	-LRB-
cord-000372-wzwpyvll	209	47	76	76	CD
cord-000372-wzwpyvll	209	48	,	,	,
cord-000372-wzwpyvll	209	49	118	118	CD
cord-000372-wzwpyvll	209	50	,	,	,
cord-000372-wzwpyvll	209	51	[	[	-LRB-
cord-000372-wzwpyvll	209	52	124	124	CD
cord-000372-wzwpyvll	209	53	]	]	-RRB-
cord-000372-wzwpyvll	209	54	[	[	-LRB-
cord-000372-wzwpyvll	209	55	125	125	CD
cord-000372-wzwpyvll	209	56	]	]	-RRB-
cord-000372-wzwpyvll	209	57	[	[	-LRB-
cord-000372-wzwpyvll	209	58	126	126	CD
cord-000372-wzwpyvll	209	59	]	]	-RRB-
cord-000372-wzwpyvll	209	60	[	[	-LRB-
cord-000372-wzwpyvll	209	61	127	127	CD
cord-000372-wzwpyvll	209	62	]	]	-RRB-
cord-000372-wzwpyvll	209	63	.	.	.
cord-000372-wzwpyvll	210	1	In	in	IN
cord-000372-wzwpyvll	210	2	this	this	DT
cord-000372-wzwpyvll	210	3	sense	sense	NN
cord-000372-wzwpyvll	210	4	,	,	,
cord-000372-wzwpyvll	210	5	the	the	DT
cord-000372-wzwpyvll	210	6	addition	addition	NN
cord-000372-wzwpyvll	210	7	of	of	IN
cord-000372-wzwpyvll	210	8	about	about	RB
cord-000372-wzwpyvll	210	9	1	1	CD
cord-000372-wzwpyvll	210	10	to	to	IN
cord-000372-wzwpyvll	210	11	5	5	CD
cord-000372-wzwpyvll	210	12	μg	μg	NN
cord-000372-wzwpyvll	211	1	MBP-2A	MBP-2A	NNP
cord-000372-wzwpyvll	211	2	pro	pro	JJ
cord-000372-wzwpyvll	211	3	suffices	suffice	VBZ
cord-000372-wzwpyvll	211	4	to	to	TO
cord-000372-wzwpyvll	211	5	hydrolyze	hydrolyze	VB
cord-000372-wzwpyvll	211	6	eIF4	eif4	IN
cord-000372-wzwpyvll	211	7	G	g	NN
cord-000372-wzwpyvll	211	8	in	in	IN
cord-000372-wzwpyvll	211	9	those	those	DT
cord-000372-wzwpyvll	211	10	cell	cell	NN
cord-000372-wzwpyvll	211	11	-	-	HYPH
cord-000372-wzwpyvll	211	12	free	free	JJ
cord-000372-wzwpyvll	211	13	systems	system	NNS
cord-000372-wzwpyvll	211	14	[	[	-LRB-
cord-000372-wzwpyvll	211	15	76	76	CD
cord-000372-wzwpyvll	211	16	,	,	,
cord-000372-wzwpyvll	211	17	[	[	-LRB-
cord-000372-wzwpyvll	211	18	125	125	CD
cord-000372-wzwpyvll	211	19	]	]	-RRB-
cord-000372-wzwpyvll	211	20	[	[	-LRB-
cord-000372-wzwpyvll	211	21	126	126	CD
cord-000372-wzwpyvll	211	22	]	]	-RRB-
cord-000372-wzwpyvll	212	1	[	[	-LRB-
cord-000372-wzwpyvll	212	2	127	127	CD
cord-000372-wzwpyvll	212	3	]	]	-RRB-
cord-000372-wzwpyvll	212	4	.	.	.
cord-000372-wzwpyvll	213	1	An	an	DT
cord-000372-wzwpyvll	213	2	alternative	alternative	JJ
cord-000372-wzwpyvll	213	3	method	method	NN
cord-000372-wzwpyvll	213	4	to	to	TO
cord-000372-wzwpyvll	213	5	cleave	cleave	VB
cord-000372-wzwpyvll	213	6	eIF4	eIF4	NNP
cord-000372-wzwpyvll	213	7	G	g	NN
cord-000372-wzwpyvll	213	8	in	in	IN
cord-000372-wzwpyvll	213	9	an	an	DT
cord-000372-wzwpyvll	213	10	in	in	FW
cord-000372-wzwpyvll	213	11	vitro	vitro	FW
cord-000372-wzwpyvll	213	12	system	system	NN
cord-000372-wzwpyvll	213	13	is	be	VBZ
cord-000372-wzwpyvll	213	14	the	the	DT
cord-000372-wzwpyvll	213	15	translation	translation	NN
cord-000372-wzwpyvll	213	16	of	of	IN
cord-000372-wzwpyvll	213	17	an	an	DT
cord-000372-wzwpyvll	213	18	mRNA	mrna	NN
cord-000372-wzwpyvll	213	19	encoding	encode	VBG
cord-000372-wzwpyvll	213	20	PV	PV	NNP
cord-000372-wzwpyvll	213	21	2A	2a	CD
cord-000372-wzwpyvll	213	22	pro	pro	JJ
cord-000372-wzwpyvll	213	23	in	in	IN
cord-000372-wzwpyvll	213	24	translation	translation	NN
cord-000372-wzwpyvll	213	25	competent	competent	JJ
cord-000372-wzwpyvll	213	26	extracts	extract	NNS
cord-000372-wzwpyvll	213	27	[	[	-LRB-
cord-000372-wzwpyvll	213	28	50	50	CD
cord-000372-wzwpyvll	213	29	]	]	-RRB-
cord-000372-wzwpyvll	213	30	.	.	.
cord-000372-wzwpyvll	214	1	This	this	DT
cord-000372-wzwpyvll	214	2	assay	assay	NN
cord-000372-wzwpyvll	214	3	has	have	VBZ
cord-000372-wzwpyvll	214	4	the	the	DT
cord-000372-wzwpyvll	214	5	advantage	advantage	NN
cord-000372-wzwpyvll	214	6	of	of	IN
cord-000372-wzwpyvll	214	7	providing	provide	VBG
cord-000372-wzwpyvll	214	8	genuine	genuine	JJ
cord-000372-wzwpyvll	214	9	and	and	CC
cord-000372-wzwpyvll	214	10	freshly	freshly	RB
cord-000372-wzwpyvll	214	11	made	make	VBN
cord-000372-wzwpyvll	214	12	PV	PV	NNP
cord-000372-wzwpyvll	214	13	2A	2a	CD
cord-000372-wzwpyvll	214	14	pro	pro	JJ
cord-000372-wzwpyvll	214	15	,	,	,
cord-000372-wzwpyvll	214	16	leading	lead	VBG
cord-000372-wzwpyvll	214	17	to	to	IN
cord-000372-wzwpyvll	214	18	total	total	JJ
cord-000372-wzwpyvll	214	19	cleavage	cleavage	NN
cord-000372-wzwpyvll	214	20	of	of	IN
cord-000372-wzwpyvll	214	21	eIF4	eIF4	NNP
cord-000372-wzwpyvll	214	22	G	g	NN
cord-000372-wzwpyvll	214	23	in	in	IN
cord-000372-wzwpyvll	214	24	the	the	DT
cord-000372-wzwpyvll	214	25	test	test	NN
cord-000372-wzwpyvll	214	26	tube	tube	NN
cord-000372-wzwpyvll	214	27	after	after	IN
cord-000372-wzwpyvll	214	28	several	several	JJ
cord-000372-wzwpyvll	214	29	minutes	minute	NNS
cord-000372-wzwpyvll	214	30	of	of	IN
cord-000372-wzwpyvll	214	31	translation	translation	NN
cord-000372-wzwpyvll	214	32	.	.	.
cord-000372-wzwpyvll	215	1	Many	many	JJ
cord-000372-wzwpyvll	215	2	different	different	JJ
cord-000372-wzwpyvll	215	3	approaches	approach	NNS
cord-000372-wzwpyvll	215	4	have	have	VBP
cord-000372-wzwpyvll	215	5	been	be	VBN
cord-000372-wzwpyvll	215	6	explored	explore	VBN
cord-000372-wzwpyvll	215	7	in	in	IN
cord-000372-wzwpyvll	215	8	culture	culture	NN
cord-000372-wzwpyvll	215	9	cells	cell	NNS
cord-000372-wzwpyvll	215	10	,	,	,
cord-000372-wzwpyvll	215	11	the	the	DT
cord-000372-wzwpyvll	215	12	most	most	RBS
cord-000372-wzwpyvll	215	13	popular	popular	JJ
cord-000372-wzwpyvll	215	14	being	be	VBG
cord-000372-wzwpyvll	215	15	transfection	transfection	NN
cord-000372-wzwpyvll	215	16	of	of	IN
cord-000372-wzwpyvll	215	17	plasmids	plasmid	NNS
cord-000372-wzwpyvll	215	18	encoding	encode	VBG
cord-000372-wzwpyvll	215	19	PV	PV	NNP
cord-000372-wzwpyvll	215	20	2A	2a	CD
cord-000372-wzwpyvll	215	21	pro	pro	JJ
cord-000372-wzwpyvll	215	22	in	in	IN
cord-000372-wzwpyvll	215	23	different	different	JJ
cord-000372-wzwpyvll	215	24	eukaryotic	eukaryotic	JJ
cord-000372-wzwpyvll	215	25	cell	cell	NN
cord-000372-wzwpyvll	215	26	types	type	NNS
cord-000372-wzwpyvll	215	27	[	[	-LRB-
cord-000372-wzwpyvll	215	28	75	75	CD
cord-000372-wzwpyvll	215	29	,	,	,
cord-000372-wzwpyvll	215	30	76	76	CD
cord-000372-wzwpyvll	215	31	,	,	,
cord-000372-wzwpyvll	215	32	[	[	-LRB-
cord-000372-wzwpyvll	215	33	128	128	CD
cord-000372-wzwpyvll	215	34	]	]	-RRB-
cord-000372-wzwpyvll	215	35	[	[	-LRB-
cord-000372-wzwpyvll	215	36	129	129	CD
cord-000372-wzwpyvll	215	37	]	]	-RRB-
cord-000372-wzwpyvll	215	38	[	[	-LRB-
cord-000372-wzwpyvll	215	39	130	130	CD
cord-000372-wzwpyvll	215	40	]	]	-RRB-
cord-000372-wzwpyvll	215	41	[	[	-LRB-
cord-000372-wzwpyvll	215	42	131	131	CD
cord-000372-wzwpyvll	215	43	]	]	-RRB-
cord-000372-wzwpyvll	215	44	[	[	-LRB-
cord-000372-wzwpyvll	215	45	132	132	CD
cord-000372-wzwpyvll	215	46	]	]	-RRB-
cord-000372-wzwpyvll	215	47	[	[	-LRB-
cord-000372-wzwpyvll	215	48	133	133	CD
cord-000372-wzwpyvll	215	49	]	]	-RRB-
cord-000372-wzwpyvll	215	50	[	[	-LRB-
cord-000372-wzwpyvll	215	51	134	134	CD
cord-000372-wzwpyvll	215	52	]	]	-RRB-
cord-000372-wzwpyvll	215	53	.	.	.
cord-000372-wzwpyvll	216	1	Several	several	JJ
cord-000372-wzwpyvll	216	2	plasmids	plasmid	NNS
cord-000372-wzwpyvll	216	3	have	have	VBP
cord-000372-wzwpyvll	216	4	been	be	VBN
cord-000372-wzwpyvll	216	5	utilized	utilize	VBN
cord-000372-wzwpyvll	216	6	in	in	IN
cord-000372-wzwpyvll	216	7	this	this	DT
cord-000372-wzwpyvll	216	8	respect	respect	NN
cord-000372-wzwpyvll	216	9	,	,	,
cord-000372-wzwpyvll	216	10	and	and	CC
cord-000372-wzwpyvll	216	11	perhaps	perhaps	RB
cord-000372-wzwpyvll	216	12	the	the	DT
cord-000372-wzwpyvll	216	13	most	most	RBS
cord-000372-wzwpyvll	216	14	successful	successful	JJ
cord-000372-wzwpyvll	216	15	one	one	NN
cord-000372-wzwpyvll	216	16	is	be	VBZ
cord-000372-wzwpyvll	216	17	pTM1	pTM1	NNP
cord-000372-wzwpyvll	216	18	-	-	HYPH
cord-000372-wzwpyvll	216	19	2A	2A	NNP
cord-000372-wzwpyvll	216	20	,	,	,
cord-000372-wzwpyvll	216	21	which	which	WDT
cord-000372-wzwpyvll	216	22	is	be	VBZ
cord-000372-wzwpyvll	216	23	transfected	transfecte	VBN
cord-000372-wzwpyvll	216	24	in	in	IN
cord-000372-wzwpyvll	216	25	mammalian	mammalian	JJ
cord-000372-wzwpyvll	216	26	cells	cell	NNS
cord-000372-wzwpyvll	216	27	that	that	WDT
cord-000372-wzwpyvll	216	28	transiently	transiently	RB
cord-000372-wzwpyvll	216	29	express	express	VBP
cord-000372-wzwpyvll	216	30	T7	T7	NNP
cord-000372-wzwpyvll	216	31	RNA	RNA	NNP
cord-000372-wzwpyvll	216	32	polymerase	polymerase	NN
cord-000372-wzwpyvll	216	33	by	by	IN
cord-000372-wzwpyvll	216	34	infection	infection	NN
cord-000372-wzwpyvll	216	35	with	with	IN
cord-000372-wzwpyvll	216	36	a	a	DT
cord-000372-wzwpyvll	216	37	recombinant	recombinant	JJ
cord-000372-wzwpyvll	216	38	vaccinia	vaccinia	NN
cord-000372-wzwpyvll	216	39	T7	t7	NN
cord-000372-wzwpyvll	216	40	virus	virus	NN
cord-000372-wzwpyvll	216	41	[	[	-LRB-
cord-000372-wzwpyvll	216	42	76	76	CD
cord-000372-wzwpyvll	216	43	,	,	,
cord-000372-wzwpyvll	216	44	130	130	CD
cord-000372-wzwpyvll	216	45	,	,	,
cord-000372-wzwpyvll	216	46	131	131	CD
cord-000372-wzwpyvll	216	47	,	,	,
cord-000372-wzwpyvll	216	48	133	133	CD
cord-000372-wzwpyvll	216	49	,	,	,
cord-000372-wzwpyvll	216	50	134	134	CD
cord-000372-wzwpyvll	216	51	]	]	-RRB-
cord-000372-wzwpyvll	216	52	.	.	.
cord-000372-wzwpyvll	217	1	The	the	DT
cord-000372-wzwpyvll	217	2	amount	amount	NN
cord-000372-wzwpyvll	217	3	of	of	IN
cord-000372-wzwpyvll	217	4	protease	protease	NN
cord-000372-wzwpyvll	217	5	synthesized	synthesize	VBN
cord-000372-wzwpyvll	217	6	in	in	IN
cord-000372-wzwpyvll	217	7	this	this	DT
cord-000372-wzwpyvll	217	8	system	system	NN
cord-000372-wzwpyvll	217	9	is	be	VBZ
cord-000372-wzwpyvll	217	10	similar	similar	JJ
cord-000372-wzwpyvll	217	11	to	to	IN
cord-000372-wzwpyvll	217	12	that	that	DT
cord-000372-wzwpyvll	217	13	found	find	VBN
cord-000372-wzwpyvll	217	14	in	in	IN
cord-000372-wzwpyvll	217	15	PV	pv	NN
cord-000372-wzwpyvll	217	16	-	-	HYPH
cord-000372-wzwpyvll	217	17	infected	infect	VBN
cord-000372-wzwpyvll	217	18	cells	cell	NNS
cord-000372-wzwpyvll	217	19	at	at	IN
cord-000372-wzwpyvll	217	20	late	late	JJ
cord-000372-wzwpyvll	217	21	times	time	NNS
cord-000372-wzwpyvll	217	22	of	of	IN
cord-000372-wzwpyvll	217	23	infection	infection	NN
cord-000372-wzwpyvll	217	24	,	,	,
cord-000372-wzwpyvll	217	25	but	but	CC
cord-000372-wzwpyvll	217	26	these	these	DT
cord-000372-wzwpyvll	217	27	amounts	amount	NNS
cord-000372-wzwpyvll	217	28	are	be	VBP
cord-000372-wzwpyvll	217	29	reached	reach	VBN
cord-000372-wzwpyvll	217	30	1	1	CD
cord-000372-wzwpyvll	217	31	-	-	SYM
cord-000372-wzwpyvll	217	32	2	2	CD
cord-000372-wzwpyvll	217	33	hours	hour	NNS
cord-000372-wzwpyvll	217	34	after	after	IN
cord-000372-wzwpyvll	217	35	transfection	transfection	NN
cord-000372-wzwpyvll	217	36	.	.	.
cord-000372-wzwpyvll	218	1	Similar	similar	JJ
cord-000372-wzwpyvll	218	2	results	result	NNS
cord-000372-wzwpyvll	218	3	have	have	VBP
cord-000372-wzwpyvll	218	4	been	be	VBN
cord-000372-wzwpyvll	218	5	obtained	obtain	VBN
cord-000372-wzwpyvll	218	6	in	in	IN
cord-000372-wzwpyvll	218	7	cells	cell	NNS
cord-000372-wzwpyvll	218	8	constitutively	constitutively	RB
cord-000372-wzwpyvll	218	9	expressing	express	VBG
cord-000372-wzwpyvll	218	10	T7	t7	NN
cord-000372-wzwpyvll	218	11	polymerase	polymerase	NN
cord-000372-wzwpyvll	218	12	,	,	,
cord-000372-wzwpyvll	218	13	which	which	WDT
cord-000372-wzwpyvll	218	14	comprises	comprise	VBZ
cord-000372-wzwpyvll	218	15	a	a	DT
cord-000372-wzwpyvll	218	16	less	less	RBR
cord-000372-wzwpyvll	218	17	pleiotropic	pleiotropic	JJ
cord-000372-wzwpyvll	218	18	system	system	NN
cord-000372-wzwpyvll	218	19	,	,	,
cord-000372-wzwpyvll	218	20	because	because	IN
cord-000372-wzwpyvll	218	21	vaccinia	vaccinia	NN
cord-000372-wzwpyvll	218	22	virus	virus	NN
cord-000372-wzwpyvll	218	23	proteins	protein	NNS
cord-000372-wzwpyvll	218	24	are	be	VBP
cord-000372-wzwpyvll	218	25	not	not	RB
cord-000372-wzwpyvll	218	26	expressed	express	VBN
cord-000372-wzwpyvll	218	27	(	(	-LRB-
cord-000372-wzwpyvll	218	28	unpublished	unpublished	JJ
cord-000372-wzwpyvll	218	29	data	datum	NNS
cord-000372-wzwpyvll	218	30	)	)	-RRB-
cord-000372-wzwpyvll	218	31	.	.	.
cord-000372-wzwpyvll	219	1	Since	since	IN
cord-000372-wzwpyvll	219	2	PV	PV	NNP
cord-000372-wzwpyvll	219	3	2A	2a	CD
cord-000372-wzwpyvll	219	4	pro	pro	NNP
cord-000372-wzwpyvll	219	5	targets	target	VBZ
cord-000372-wzwpyvll	219	6	a	a	DT
cord-000372-wzwpyvll	219	7	number	number	NN
cord-000372-wzwpyvll	219	8	of	of	IN
cord-000372-wzwpyvll	219	9	different	different	JJ
cord-000372-wzwpyvll	219	10	cellular	cellular	JJ
cord-000372-wzwpyvll	219	11	proteins	protein	NNS
cord-000372-wzwpyvll	219	12	,	,	,
cord-000372-wzwpyvll	219	13	which	which	WDT
cord-000372-wzwpyvll	219	14	affect	affect	VBP
cord-000372-wzwpyvll	219	15	several	several	JJ
cord-000372-wzwpyvll	219	16	cellular	cellular	JJ
cord-000372-wzwpyvll	219	17	functions	function	NNS
cord-000372-wzwpyvll	219	18	depending	depend	VBG
cord-000372-wzwpyvll	219	19	on	on	IN
cord-000372-wzwpyvll	219	20	the	the	DT
cord-000372-wzwpyvll	219	21	amount	amount	NN
cord-000372-wzwpyvll	219	22	of	of	IN
cord-000372-wzwpyvll	219	23	protease	protease	NN
cord-000372-wzwpyvll	219	24	synthesized	synthesize	VBN
cord-000372-wzwpyvll	219	25	(	(	-LRB-
cord-000372-wzwpyvll	219	26	see	see	VB
cord-000372-wzwpyvll	219	27	below	below	RB
cord-000372-wzwpyvll	219	28	)	)	-RRB-
cord-000372-wzwpyvll	219	29	,	,	,
cord-000372-wzwpyvll	219	30	in	in	IN
cord-000372-wzwpyvll	219	31	some	some	DT
cord-000372-wzwpyvll	219	32	instances	instance	NNS
cord-000372-wzwpyvll	219	33	,	,	,
cord-000372-wzwpyvll	219	34	it	-PRON-	PRP
cord-000372-wzwpyvll	219	35	is	be	VBZ
cord-000372-wzwpyvll	219	36	useful	useful	JJ
cord-000372-wzwpyvll	219	37	to	to	TO
cord-000372-wzwpyvll	219	38	express	express	VB
cord-000372-wzwpyvll	219	39	2A	2A	NNP
cord-000372-wzwpyvll	219	40	pro	pro	NNP
cord-000372-wzwpyvll	219	41	at	at	IN
cord-000372-wzwpyvll	219	42	low	low	JJ
cord-000372-wzwpyvll	219	43	levels	level	NNS
cord-000372-wzwpyvll	219	44	.	.	.
cord-000372-wzwpyvll	220	1	We	-PRON-	PRP
cord-000372-wzwpyvll	220	2	have	have	VBP
cord-000372-wzwpyvll	220	3	explored	explore	VBN
cord-000372-wzwpyvll	220	4	many	many	JJ
cord-000372-wzwpyvll	220	5	alternative	alternative	JJ
cord-000372-wzwpyvll	220	6	methods	method	NNS
cord-000372-wzwpyvll	220	7	trying	try	VBG
cord-000372-wzwpyvll	220	8	to	to	TO
cord-000372-wzwpyvll	220	9	get	get	VB
cord-000372-wzwpyvll	220	10	a	a	DT
cord-000372-wzwpyvll	220	11	system	system	NN
cord-000372-wzwpyvll	220	12	that	that	WDT
cord-000372-wzwpyvll	220	13	allows	allow	VBZ
cord-000372-wzwpyvll	220	14	us	-PRON-	PRP
cord-000372-wzwpyvll	220	15	to	to	TO
cord-000372-wzwpyvll	220	16	control	control	VB
cord-000372-wzwpyvll	220	17	the	the	DT
cord-000372-wzwpyvll	220	18	levels	level	NNS
cord-000372-wzwpyvll	220	19	of	of	IN
cord-000372-wzwpyvll	220	20	PV	PV	NNP
cord-000372-wzwpyvll	220	21	2A	2a	CD
cord-000372-wzwpyvll	220	22	pro	pro	JJ
cord-000372-wzwpyvll	220	23	into	into	IN
cord-000372-wzwpyvll	220	24	the	the	DT
cord-000372-wzwpyvll	220	25	cells	cell	NNS
cord-000372-wzwpyvll	220	26	.	.	.
cord-000372-wzwpyvll	221	1	Novoa	Novoa	NNP
cord-000372-wzwpyvll	221	2	and	and	CC
cord-000372-wzwpyvll	221	3	colleagues	colleague	NNS
cord-000372-wzwpyvll	221	4	developed	develop	VBD
cord-000372-wzwpyvll	221	5	a	a	DT
cord-000372-wzwpyvll	221	6	protocol	protocol	NN
cord-000372-wzwpyvll	221	7	based	base	VBN
cord-000372-wzwpyvll	221	8	on	on	IN
cord-000372-wzwpyvll	221	9	the	the	DT
cord-000372-wzwpyvll	221	10	addition	addition	NN
cord-000372-wzwpyvll	221	11	of	of	IN
cord-000372-wzwpyvll	221	12	hybrid	hybrid	JJ
cord-000372-wzwpyvll	221	13	proteins	protein	NNS
cord-000372-wzwpyvll	221	14	bearing	bear	VBG
cord-000372-wzwpyvll	221	15	PV	PV	NNP
cord-000372-wzwpyvll	221	16	2A	2a	NN
cord-000372-wzwpyvll	221	17	pro	pro	JJ
cord-000372-wzwpyvll	221	18	.	.	.
cord-000372-wzwpyvll	222	1	These	these	DT
cord-000372-wzwpyvll	222	2	recombinant	recombinant	JJ
cord-000372-wzwpyvll	222	3	proteins	protein	NNS
cord-000372-wzwpyvll	222	4	enter	enter	VBP
cord-000372-wzwpyvll	222	5	into	into	IN
cord-000372-wzwpyvll	222	6	the	the	DT
cord-000372-wzwpyvll	222	7	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	222	8	on	on	IN
cord-000372-wzwpyvll	222	9	cell	cell	NN
cord-000372-wzwpyvll	222	10	membrane	membrane	NN
cord-000372-wzwpyvll	222	11	permeabilization	permeabilization	NN
cord-000372-wzwpyvll	222	12	by	by	IN
cord-000372-wzwpyvll	222	13	different	different	JJ
cord-000372-wzwpyvll	222	14	methods	method	NNS
cord-000372-wzwpyvll	222	15	such	such	JJ
cord-000372-wzwpyvll	222	16	as	as	IN
cord-000372-wzwpyvll	222	17	addition	addition	NN
cord-000372-wzwpyvll	222	18	of	of	IN
cord-000372-wzwpyvll	222	19	MBP-2A	MBP-2A	NNP
cord-000372-wzwpyvll	222	20	pro	pro	JJ
cord-000372-wzwpyvll	222	21	mixed	mixed	JJ
cord-000372-wzwpyvll	222	22	with	with	IN
cord-000372-wzwpyvll	222	23	replicationally	replicationally	RB
cord-000372-wzwpyvll	222	24	inactive	inactive	JJ
cord-000372-wzwpyvll	222	25	chicken	chicken	NN
cord-000372-wzwpyvll	222	26	adenovirus	adenovirus	NN
cord-000372-wzwpyvll	222	27	particles	particle	NNS
cord-000372-wzwpyvll	222	28	[	[	-LRB-
cord-000372-wzwpyvll	222	29	135	135	CD
cord-000372-wzwpyvll	222	30	]	]	-RRB-
cord-000372-wzwpyvll	222	31	.	.	.
cord-000372-wzwpyvll	223	1	Cleavage	cleavage	NN
cord-000372-wzwpyvll	223	2	of	of	IN
cord-000372-wzwpyvll	223	3	eIF4	eIF4	NNP
cord-000372-wzwpyvll	223	4	G	g	NN
cord-000372-wzwpyvll	223	5	following	follow	VBG
cord-000372-wzwpyvll	223	6	these	these	DT
cord-000372-wzwpyvll	223	7	protocols	protocol	NNS
cord-000372-wzwpyvll	223	8	takes	take	VBZ
cord-000372-wzwpyvll	223	9	place	place	NN
cord-000372-wzwpyvll	223	10	after	after	IN
cord-000372-wzwpyvll	223	11	incubation	incubation	NN
cord-000372-wzwpyvll	223	12	for	for	IN
cord-000372-wzwpyvll	223	13	8	8	CD
cord-000372-wzwpyvll	223	14	-	-	SYM
cord-000372-wzwpyvll	223	15	10	10	CD
cord-000372-wzwpyvll	223	16	hours	hour	NNS
cord-000372-wzwpyvll	223	17	,	,	,
cord-000372-wzwpyvll	223	18	suggesting	suggest	VBG
cord-000372-wzwpyvll	223	19	that	that	IN
cord-000372-wzwpyvll	223	20	the	the	DT
cord-000372-wzwpyvll	223	21	amount	amount	NN
cord-000372-wzwpyvll	223	22	of	of	IN
cord-000372-wzwpyvll	223	23	protease	protease	NN
cord-000372-wzwpyvll	223	24	internalized	internalize	VBN
cord-000372-wzwpyvll	223	25	is	be	VBZ
cord-000372-wzwpyvll	223	26	probably	probably	RB
cord-000372-wzwpyvll	223	27	low	low	JJ
cord-000372-wzwpyvll	223	28	but	but	CC
cord-000372-wzwpyvll	223	29	sufficient	sufficient	JJ
cord-000372-wzwpyvll	223	30	to	to	TO
cord-000372-wzwpyvll	223	31	hydrolyze	hydrolyze	VB
cord-000372-wzwpyvll	223	32	eIF4GI	eIF4GI	NNS
cord-000372-wzwpyvll	223	33	in	in	IN
cord-000372-wzwpyvll	223	34	virtually	virtually	RB
cord-000372-wzwpyvll	223	35	all	all	DT
cord-000372-wzwpyvll	223	36	culture	culture	NN
cord-000372-wzwpyvll	223	37	cells	cell	NNS
cord-000372-wzwpyvll	223	38	[	[	-LRB-
cord-000372-wzwpyvll	223	39	136	136	CD
cord-000372-wzwpyvll	223	40	]	]	-RRB-
cord-000372-wzwpyvll	223	41	.	.	.
cord-000372-wzwpyvll	224	1	Probably	probably	RB
cord-000372-wzwpyvll	224	2	one	one	CD
cord-000372-wzwpyvll	224	3	of	of	IN
cord-000372-wzwpyvll	224	4	the	the	DT
cord-000372-wzwpyvll	224	5	most	most	RBS
cord-000372-wzwpyvll	224	6	attractive	attractive	JJ
cord-000372-wzwpyvll	224	7	systems	system	NNS
cord-000372-wzwpyvll	224	8	is	be	VBZ
cord-000372-wzwpyvll	224	9	a	a	DT
cord-000372-wzwpyvll	224	10	stable	stable	JJ
cord-000372-wzwpyvll	224	11	cell	cell	NN
cord-000372-wzwpyvll	224	12	line	line	NN
cord-000372-wzwpyvll	224	13	that	that	WDT
cord-000372-wzwpyvll	224	14	inducibly	inducibly	RB
cord-000372-wzwpyvll	224	15	express	express	VBP
cord-000372-wzwpyvll	224	16	PV	PV	NNP
cord-000372-wzwpyvll	224	17	2A	2a	CD
cord-000372-wzwpyvll	224	18	pro	pro	NNP
cord-000372-wzwpyvll	224	19	,	,	,
cord-000372-wzwpyvll	224	20	obtained	obtain	VBN
cord-000372-wzwpyvll	224	21	in	in	IN
cord-000372-wzwpyvll	224	22	two	two	CD
cord-000372-wzwpyvll	224	23	different	different	JJ
cord-000372-wzwpyvll	224	24	laboratories	laboratory	NNS
cord-000372-wzwpyvll	224	25	including	include	VBG
cord-000372-wzwpyvll	224	26	ours	-PRON-	PRP
cord-000372-wzwpyvll	224	27	[	[	-LRB-
cord-000372-wzwpyvll	224	28	137	137	CD
cord-000372-wzwpyvll	224	29	,	,	,
cord-000372-wzwpyvll	224	30	138	138	CD
cord-000372-wzwpyvll	224	31	]	]	-RRB-
cord-000372-wzwpyvll	224	32	.	.	.
cord-000372-wzwpyvll	225	1	In	in	IN
cord-000372-wzwpyvll	225	2	these	these	DT
cord-000372-wzwpyvll	225	3	cell	cell	NN
cord-000372-wzwpyvll	225	4	lines	line	NNS
cord-000372-wzwpyvll	225	5	,	,	,
cord-000372-wzwpyvll	225	6	PV	PV	NNP
cord-000372-wzwpyvll	225	7	2A	2a	NN
cord-000372-wzwpyvll	225	8	pro	pro	NNP
cord-000372-wzwpyvll	225	9	is	be	VBZ
cord-000372-wzwpyvll	225	10	synthesized	synthesize	VBN
cord-000372-wzwpyvll	225	11	when	when	WRB
cord-000372-wzwpyvll	225	12	tretracycline	tretracycline	NN
cord-000372-wzwpyvll	225	13	is	be	VBZ
cord-000372-wzwpyvll	225	14	removed	remove	VBN
cord-000372-wzwpyvll	225	15	from	from	IN
cord-000372-wzwpyvll	225	16	the	the	DT
cord-000372-wzwpyvll	225	17	culture	culture	NN
cord-000372-wzwpyvll	225	18	medium	medium	NN
cord-000372-wzwpyvll	225	19	,	,	,
cord-000372-wzwpyvll	225	20	leading	lead	VBG
cord-000372-wzwpyvll	225	21	to	to	IN
cord-000372-wzwpyvll	225	22	low	low	JJ
cord-000372-wzwpyvll	225	23	expression	expression	NN
cord-000372-wzwpyvll	225	24	of	of	IN
cord-000372-wzwpyvll	225	25	PV	PV	NNP
cord-000372-wzwpyvll	225	26	2A	2a	CD
cord-000372-wzwpyvll	225	27	pro	pro	NNP
cord-000372-wzwpyvll	225	28	that	that	WDT
cord-000372-wzwpyvll	225	29	induces	induce	VBZ
cord-000372-wzwpyvll	225	30	efficient	efficient	JJ
cord-000372-wzwpyvll	225	31	cleavage	cleavage	NN
cord-000372-wzwpyvll	225	32	of	of	IN
cord-000372-wzwpyvll	225	33	eIF4	eIF4	NNP
cord-000372-wzwpyvll	225	34	G	G	NNP
cord-000372-wzwpyvll	225	35	after	after	IN
cord-000372-wzwpyvll	225	36	13	13	CD
cord-000372-wzwpyvll	225	37	h	h	NN
cord-000372-wzwpyvll	225	38	post	post	NN
cord-000372-wzwpyvll	225	39	induction	induction	NN
cord-000372-wzwpyvll	225	40	correlating	correlate	VBG
cord-000372-wzwpyvll	225	41	with	with	IN
cord-000372-wzwpyvll	225	42	a	a	DT
cord-000372-wzwpyvll	225	43	potent	potent	JJ
cord-000372-wzwpyvll	225	44	inhibition	inhibition	NN
cord-000372-wzwpyvll	225	45	of	of	IN
cord-000372-wzwpyvll	225	46	cellular	cellular	JJ
cord-000372-wzwpyvll	225	47	translation	translation	NN
cord-000372-wzwpyvll	225	48	.	.	.
cord-000372-wzwpyvll	226	1	Finally	finally	RB
cord-000372-wzwpyvll	226	2	,	,	,
cord-000372-wzwpyvll	226	3	long	long	JJ
cord-000372-wzwpyvll	226	4	term	term	NN
cord-000372-wzwpyvll	226	5	expression	expression	NN
cord-000372-wzwpyvll	226	6	of	of	IN
cord-000372-wzwpyvll	226	7	PV	PV	NNP
cord-000372-wzwpyvll	226	8	2A	2a	CD
cord-000372-wzwpyvll	226	9	pro	pro	NN
cord-000372-wzwpyvll	226	10	in	in	IN
cord-000372-wzwpyvll	226	11	Tet	Tet	NNP
cord-000372-wzwpyvll	226	12	off	off	IN
cord-000372-wzwpyvll	226	13	cell	cell	NN
cord-000372-wzwpyvll	226	14	lines	line	NNS
cord-000372-wzwpyvll	226	15	triggers	trigger	VBZ
cord-000372-wzwpyvll	226	16	apoptosis	apoptosis	NN
cord-000372-wzwpyvll	226	17	[	[	-LRB-
cord-000372-wzwpyvll	226	18	12	12	CD
cord-000372-wzwpyvll	226	19	,	,	,
cord-000372-wzwpyvll	226	20	137	137	CD
cord-000372-wzwpyvll	226	21	,	,	,
cord-000372-wzwpyvll	226	22	138	138	CD
cord-000372-wzwpyvll	226	23	]	]	-RRB-
cord-000372-wzwpyvll	226	24	.	.	.
cord-000372-wzwpyvll	227	1	The	the	DT
cord-000372-wzwpyvll	227	2	main	main	JJ
cord-000372-wzwpyvll	227	3	drawback	drawback	NN
cord-000372-wzwpyvll	227	4	of	of	IN
cord-000372-wzwpyvll	227	5	this	this	DT
cord-000372-wzwpyvll	227	6	cell	cell	NN
cord-000372-wzwpyvll	227	7	line	line	NN
cord-000372-wzwpyvll	227	8	is	be	VBZ
cord-000372-wzwpyvll	227	9	the	the	DT
cord-000372-wzwpyvll	227	10	low	low	JJ
cord-000372-wzwpyvll	227	11	PV	pv	NN
cord-000372-wzwpyvll	227	12	2A	2a	NN
cord-000372-wzwpyvll	227	13	pro	pro	JJ
cord-000372-wzwpyvll	227	14	escape	escape	NN
cord-000372-wzwpyvll	227	15	under	under	IN
cord-000372-wzwpyvll	227	16	repression	repression	NN
cord-000372-wzwpyvll	227	17	conditions	condition	NNS
cord-000372-wzwpyvll	227	18	that	that	WDT
cord-000372-wzwpyvll	227	19	gives	give	VBZ
cord-000372-wzwpyvll	227	20	rise	rise	NN
cord-000372-wzwpyvll	227	21	to	to	IN
cord-000372-wzwpyvll	227	22	a	a	DT
cord-000372-wzwpyvll	227	23	basal	basal	NN
cord-000372-wzwpyvll	227	24	cytotoxicity	cytotoxicity	NN
cord-000372-wzwpyvll	227	25	.	.	.
cord-000372-wzwpyvll	228	1	Probably	probably	RB
cord-000372-wzwpyvll	228	2	,	,	,
cord-000372-wzwpyvll	228	3	the	the	DT
cord-000372-wzwpyvll	228	4	most	most	RBS
cord-000372-wzwpyvll	228	5	efficient	efficient	JJ
cord-000372-wzwpyvll	228	6	method	method	NN
cord-000372-wzwpyvll	228	7	is	be	VBZ
cord-000372-wzwpyvll	228	8	electroporation	electroporation	NN
cord-000372-wzwpyvll	228	9	of	of	IN
cord-000372-wzwpyvll	228	10	an	an	DT
cord-000372-wzwpyvll	228	11	mRNA	mrna	NN
cord-000372-wzwpyvll	228	12	encoding	encode	VBG
cord-000372-wzwpyvll	228	13	2A	2a	CD
cord-000372-wzwpyvll	228	14	pro	pro	JJ
cord-000372-wzwpyvll	228	15	under	under	IN
cord-000372-wzwpyvll	228	16	the	the	DT
cord-000372-wzwpyvll	228	17	control	control	NN
cord-000372-wzwpyvll	228	18	of	of	IN
cord-000372-wzwpyvll	228	19	EMCV	EMCV	NNP
cord-000372-wzwpyvll	228	20	leader	leader	NN
cord-000372-wzwpyvll	228	21	sequence	sequence	NN
cord-000372-wzwpyvll	228	22	(	(	-LRB-
cord-000372-wzwpyvll	228	23	IRES-2A	IRES-2A	NNP
cord-000372-wzwpyvll	228	24	)	)	-RRB-
cord-000372-wzwpyvll	228	25	[	[	-LRB-
cord-000372-wzwpyvll	228	26	95	95	CD
cord-000372-wzwpyvll	228	27	]	]	-RRB-
cord-000372-wzwpyvll	228	28	.	.	.
cord-000372-wzwpyvll	229	1	The	the	DT
cord-000372-wzwpyvll	229	2	biggest	big	JJS
cord-000372-wzwpyvll	229	3	advantage	advantage	NN
cord-000372-wzwpyvll	229	4	of	of	IN
cord-000372-wzwpyvll	229	5	this	this	DT
cord-000372-wzwpyvll	229	6	method	method	NN
cord-000372-wzwpyvll	229	7	is	be	VBZ
cord-000372-wzwpyvll	229	8	the	the	DT
cord-000372-wzwpyvll	229	9	capacity	capacity	NN
cord-000372-wzwpyvll	229	10	to	to	TO
cord-000372-wzwpyvll	229	11	regulate	regulate	VB
cord-000372-wzwpyvll	229	12	levels	level	NNS
cord-000372-wzwpyvll	229	13	of	of	IN
cord-000372-wzwpyvll	229	14	2A	2a	CD
cord-000372-wzwpyvll	229	15	pro	pro	JJ
cord-000372-wzwpyvll	229	16	expression	expression	NN
cord-000372-wzwpyvll	229	17	by	by	IN
cord-000372-wzwpyvll	229	18	controlling	control	VBG
cord-000372-wzwpyvll	229	19	the	the	DT
cord-000372-wzwpyvll	229	20	amounts	amount	NNS
cord-000372-wzwpyvll	229	21	of	of	IN
cord-000372-wzwpyvll	229	22	IRES-2A	IRES-2A	NNP
cord-000372-wzwpyvll	229	23	transfected	transfecte	VBN
cord-000372-wzwpyvll	229	24	.	.	.
cord-000372-wzwpyvll	230	1	For	for	IN
cord-000372-wzwpyvll	230	2	example	example	NN
cord-000372-wzwpyvll	230	3	,	,	,
cord-000372-wzwpyvll	230	4	electroporation	electroporation	NN
cord-000372-wzwpyvll	230	5	of	of	IN
cord-000372-wzwpyvll	230	6	9	9	CD
cord-000372-wzwpyvll	230	7	μg	μg	NNS
cord-000372-wzwpyvll	230	8	of	of	IN
cord-000372-wzwpyvll	230	9	IRES-2A	IRES-2A	NNP
cord-000372-wzwpyvll	230	10	into	into	IN
cord-000372-wzwpyvll	230	11	∼	∼	NNP
cord-000372-wzwpyvll	230	12	1.5	1.5	CD
cord-000372-wzwpyvll	230	13	·	·	NFP
cord-000372-wzwpyvll	230	14	10	10	CD
cord-000372-wzwpyvll	230	15	6	6	CD
cord-000372-wzwpyvll	230	16	HeLa	HeLa	NNP
cord-000372-wzwpyvll	230	17	cells	cell	NNS
cord-000372-wzwpyvll	230	18	leads	lead	VBZ
cord-000372-wzwpyvll	230	19	to	to	IN
cord-000372-wzwpyvll	230	20	total	total	JJ
cord-000372-wzwpyvll	230	21	cleavage	cleavage	NN
cord-000372-wzwpyvll	230	22	of	of	IN
cord-000372-wzwpyvll	230	23	both	both	DT
cord-000372-wzwpyvll	230	24	eIF4GI	eIF4GI	NNS
cord-000372-wzwpyvll	230	25	and	and	CC
cord-000372-wzwpyvll	230	26	eIF4GII	eif4gii	NN
cord-000372-wzwpyvll	230	27	in	in	IN
cord-000372-wzwpyvll	230	28	only	only	JJ
cord-000372-wzwpyvll	230	29	2	2	CD
cord-000372-wzwpyvll	230	30	h	h	NN
cord-000372-wzwpyvll	230	31	,	,	,
cord-000372-wzwpyvll	230	32	resulting	result	VBG
cord-000372-wzwpyvll	230	33	in	in	IN
cord-000372-wzwpyvll	230	34	an	an	DT
cord-000372-wzwpyvll	230	35	almost	almost	RB
cord-000372-wzwpyvll	230	36	complete	complete	JJ
cord-000372-wzwpyvll	230	37	shutoff	shutoff	NN
cord-000372-wzwpyvll	230	38	of	of	IN
cord-000372-wzwpyvll	230	39	cellular	cellular	JJ
cord-000372-wzwpyvll	230	40	protein	protein	NN
cord-000372-wzwpyvll	230	41	synthesis	synthesis	NN
cord-000372-wzwpyvll	230	42	.	.	.
cord-000372-wzwpyvll	231	1	In	in	IN
cord-000372-wzwpyvll	231	2	contrast	contrast	NN
cord-000372-wzwpyvll	231	3	,	,	,
cord-000372-wzwpyvll	231	4	electroporation	electroporation	NN
cord-000372-wzwpyvll	231	5	of	of	IN
cord-000372-wzwpyvll	231	6	low	low	JJ
cord-000372-wzwpyvll	231	7	amounts	amount	NNS
cord-000372-wzwpyvll	231	8	of	of	IN
cord-000372-wzwpyvll	231	9	IRES-2A	IRES-2A	NNP
cord-000372-wzwpyvll	231	10	(	(	-LRB-
cord-000372-wzwpyvll	231	11	1	1	CD
cord-000372-wzwpyvll	231	12	μg	μg	NNP
cord-000372-wzwpyvll	231	13	)	)	-RRB-
cord-000372-wzwpyvll	231	14	into	into	IN
cord-000372-wzwpyvll	231	15	HeLa	HeLa	NNP
cord-000372-wzwpyvll	231	16	cells	cell	NNS
cord-000372-wzwpyvll	231	17	induces	induce	VBZ
cord-000372-wzwpyvll	231	18	efficient	efficient	JJ
cord-000372-wzwpyvll	231	19	cleavage	cleavage	NN
cord-000372-wzwpyvll	231	20	of	of	IN
cord-000372-wzwpyvll	231	21	eIF4GI	eIF4GI	NNS
cord-000372-wzwpyvll	231	22	,	,	,
cord-000372-wzwpyvll	231	23	whereas	whereas	IN
cord-000372-wzwpyvll	231	24	eIF4GII	eif4gii	POS
cord-000372-wzwpyvll	231	25	remains	remain	VBZ
cord-000372-wzwpyvll	231	26	largely	largely	RB
cord-000372-wzwpyvll	231	27	intact	intact	JJ
cord-000372-wzwpyvll	231	28	.	.	.
cord-000372-wzwpyvll	232	1	Therefore	therefore	RB
cord-000372-wzwpyvll	232	2	,	,	,
cord-000372-wzwpyvll	232	3	9-fold	9-fold	CD
cord-000372-wzwpyvll	232	4	more	more	JJR
cord-000372-wzwpyvll	233	1	IRES-2A	ires-2a	RB
cord-000372-wzwpyvll	234	1	mRNA	mRNA	NNP
cord-000372-wzwpyvll	234	2	is	be	VBZ
cord-000372-wzwpyvll	234	3	required	require	VBN
cord-000372-wzwpyvll	234	4	to	to	TO
cord-000372-wzwpyvll	234	5	cleave	cleave	VB
cord-000372-wzwpyvll	234	6	eIF4GII	eIF4GII	NNS
cord-000372-wzwpyvll	234	7	compared	compare	VBN
cord-000372-wzwpyvll	234	8	to	to	IN
cord-000372-wzwpyvll	234	9	eIF4GI	eif4gi	DT
cord-000372-wzwpyvll	234	10	[	[	-LRB-
cord-000372-wzwpyvll	234	11	95	95	CD
cord-000372-wzwpyvll	234	12	]	]	-RRB-
cord-000372-wzwpyvll	234	13	.	.	.
cord-000372-wzwpyvll	235	1	Based	base	VBN
cord-000372-wzwpyvll	235	2	on	on	IN
cord-000372-wzwpyvll	235	3	the	the	DT
cord-000372-wzwpyvll	235	4	IRES-2A	IRES-2A	NNP
cord-000372-wzwpyvll	235	5	mRNA	mrna	NN
cord-000372-wzwpyvll	235	6	electroporation	electroporation	NN
cord-000372-wzwpyvll	235	7	method	method	NN
cord-000372-wzwpyvll	235	8	we	-PRON-	PRP
cord-000372-wzwpyvll	235	9	were	be	VBD
cord-000372-wzwpyvll	235	10	able	able	JJ
cord-000372-wzwpyvll	235	11	to	to	TO
cord-000372-wzwpyvll	235	12	induce	induce	VB
cord-000372-wzwpyvll	235	13	the	the	DT
cord-000372-wzwpyvll	235	14	differential	differential	JJ
cord-000372-wzwpyvll	235	15	proteolysis	proteolysis	NN
cord-000372-wzwpyvll	235	16	of	of	IN
cord-000372-wzwpyvll	235	17	eIF4GI	eif4gi	NN
cord-000372-wzwpyvll	235	18	and	and	CC
cord-000372-wzwpyvll	235	19	eIF4GII	eif4gii	NN
cord-000372-wzwpyvll	235	20	in	in	IN
cord-000372-wzwpyvll	235	21	a	a	DT
cord-000372-wzwpyvll	235	22	timeand	timeand	NN
cord-000372-wzwpyvll	235	23	dose	dose	NN
cord-000372-wzwpyvll	235	24	-	-	HYPH
cord-000372-wzwpyvll	235	25	dependent	dependent	JJ
cord-000372-wzwpyvll	235	26	manner	manner	NN
cord-000372-wzwpyvll	235	27	.	.	.
cord-000372-wzwpyvll	236	1	Kinetics	Kinetics	NNP
cord-000372-wzwpyvll	236	2	of	of	IN
cord-000372-wzwpyvll	236	3	protein	protein	NN
cord-000372-wzwpyvll	236	4	synthesis	synthesis	NN
cord-000372-wzwpyvll	236	5	shutoff	shutoff	NN
cord-000372-wzwpyvll	236	6	and	and	CC
cord-000372-wzwpyvll	236	7	eIF4GII	eif4gii	NN
cord-000372-wzwpyvll	236	8	cleavage	cleavage	NN
cord-000372-wzwpyvll	236	9	is	be	VBZ
cord-000372-wzwpyvll	236	10	closely	closely	RB
cord-000372-wzwpyvll	236	11	correlated	correlate	VBN
cord-000372-wzwpyvll	236	12	in	in	IN
cord-000372-wzwpyvll	236	13	HeLa	HeLa	NNP
cord-000372-wzwpyvll	236	14	cells	cell	NNS
cord-000372-wzwpyvll	236	15	,	,	,
cord-000372-wzwpyvll	236	16	resembling	resemble	VBG
cord-000372-wzwpyvll	236	17	what	what	WP
cord-000372-wzwpyvll	236	18	was	be	VBD
cord-000372-wzwpyvll	236	19	found	find	VBN
cord-000372-wzwpyvll	236	20	in	in	IN
cord-000372-wzwpyvll	236	21	PV	pv	NN
cord-000372-wzwpyvll	236	22	-	-	HYPH
cord-000372-wzwpyvll	236	23	infected	infect	VBN
cord-000372-wzwpyvll	236	24	cells	cell	NNS
cord-000372-wzwpyvll	236	25	[	[	-LRB-
cord-000372-wzwpyvll	236	26	122	122	CD
cord-000372-wzwpyvll	236	27	]	]	-RRB-
cord-000372-wzwpyvll	236	28	.	.	.
cord-000372-wzwpyvll	237	1	In	in	IN
cord-000372-wzwpyvll	237	2	agreement	agreement	NN
cord-000372-wzwpyvll	237	3	with	with	IN
cord-000372-wzwpyvll	237	4	what	what	WP
cord-000372-wzwpyvll	237	5	was	be	VBD
cord-000372-wzwpyvll	237	6	observed	observe	VBN
cord-000372-wzwpyvll	237	7	with	with	IN
cord-000372-wzwpyvll	237	8	the	the	DT
cord-000372-wzwpyvll	237	9	addition	addition	NN
cord-000372-wzwpyvll	237	10	of	of	IN
cord-000372-wzwpyvll	237	11	exogenous	exogenous	JJ
cord-000372-wzwpyvll	237	12	recombinant	recombinant	JJ
cord-000372-wzwpyvll	237	13	proteins	protein	NNS
cord-000372-wzwpyvll	237	14	[	[	-LRB-
cord-000372-wzwpyvll	237	15	136	136	CD
cord-000372-wzwpyvll	237	16	]	]	-RRB-
cord-000372-wzwpyvll	237	17	,	,	,
cord-000372-wzwpyvll	237	18	translation	translation	NN
cord-000372-wzwpyvll	237	19	of	of	IN
cord-000372-wzwpyvll	237	20	de	de	NNP
cord-000372-wzwpyvll	237	21	novo	novo	NNP
cord-000372-wzwpyvll	237	22	synthesized	synthesize	VBN
cord-000372-wzwpyvll	237	23	mRNAs	mRNAs	NNPS
cord-000372-wzwpyvll	237	24	showed	show	VBD
cord-000372-wzwpyvll	237	25	higher	high	JJR
cord-000372-wzwpyvll	237	26	susceptibility	susceptibility	NN
cord-000372-wzwpyvll	237	27	to	to	IN
cord-000372-wzwpyvll	237	28	low	low	JJ
cord-000372-wzwpyvll	237	29	doses	dose	NNS
cord-000372-wzwpyvll	237	30	of	of	IN
cord-000372-wzwpyvll	237	31	PV	PV	NNP
cord-000372-wzwpyvll	237	32	2A	2a	CD
cord-000372-wzwpyvll	237	33	pro	pro	JJ
cord-000372-wzwpyvll	237	34	than	than	IN
cord-000372-wzwpyvll	237	35	mRNAs	mrnas	XX
cord-000372-wzwpyvll	237	36	already	already	RB
cord-000372-wzwpyvll	237	37	engaged	engage	VBN
cord-000372-wzwpyvll	237	38	in	in	IN
cord-000372-wzwpyvll	237	39	translational	translational	JJ
cord-000372-wzwpyvll	237	40	machinery	machinery	NN
cord-000372-wzwpyvll	237	41	[	[	-LRB-
cord-000372-wzwpyvll	237	42	95	95	CD
cord-000372-wzwpyvll	237	43	]	]	-RRB-
cord-000372-wzwpyvll	237	44	.	.	.
cord-000372-wzwpyvll	238	1	These	these	DT
cord-000372-wzwpyvll	238	2	results	result	NNS
cord-000372-wzwpyvll	238	3	suggested	suggest	VBD
cord-000372-wzwpyvll	238	4	a	a	DT
cord-000372-wzwpyvll	238	5	possible	possible	JJ
cord-000372-wzwpyvll	238	6	specific	specific	JJ
cord-000372-wzwpyvll	238	7	role	role	NN
cord-000372-wzwpyvll	238	8	of	of	IN
cord-000372-wzwpyvll	238	9	eIF4GI	eIF4GI	NNS
cord-000372-wzwpyvll	238	10	in	in	IN
cord-000372-wzwpyvll	238	11	the	the	DT
cord-000372-wzwpyvll	238	12	pioneer	pioneer	JJ
cord-000372-wzwpyvll	238	13	round	round	NN
cord-000372-wzwpyvll	238	14	of	of	IN
cord-000372-wzwpyvll	238	15	translation	translation	NN
cord-000372-wzwpyvll	238	16	in	in	IN
cord-000372-wzwpyvll	238	17	agreement	agreement	NN
cord-000372-wzwpyvll	238	18	with	with	IN
cord-000372-wzwpyvll	238	19	a	a	DT
cord-000372-wzwpyvll	238	20	previous	previous	JJ
cord-000372-wzwpyvll	238	21	report	report	NN
cord-000372-wzwpyvll	238	22	[	[	-LRB-
cord-000372-wzwpyvll	238	23	139	139	CD
cord-000372-wzwpyvll	238	24	]	]	-RRB-
cord-000372-wzwpyvll	238	25	.	.	.
cord-000372-wzwpyvll	239	1	However	however	RB
cord-000372-wzwpyvll	239	2	,	,	,
cord-000372-wzwpyvll	239	3	specific	specific	JJ
cord-000372-wzwpyvll	239	4	ablation	ablation	NN
cord-000372-wzwpyvll	239	5	of	of	IN
cord-000372-wzwpyvll	239	6	eIF4GI	eIF4GI	NNS
cord-000372-wzwpyvll	239	7	using	use	VBG
cord-000372-wzwpyvll	239	8	siRNAs	siRNAs	NNP
cord-000372-wzwpyvll	239	9	induced	induce	VBD
cord-000372-wzwpyvll	239	10	a	a	DT
cord-000372-wzwpyvll	239	11	moderate	moderate	JJ
cord-000372-wzwpyvll	239	12	inhibition	inhibition	NN
cord-000372-wzwpyvll	239	13	of	of	IN
cord-000372-wzwpyvll	239	14	luciferase	luciferase	JJ
cord-000372-wzwpyvll	239	15	synthesis	synthesis	NN
cord-000372-wzwpyvll	239	16	from	from	IN
cord-000372-wzwpyvll	239	17	de	de	NNP
cord-000372-wzwpyvll	239	18	novo	novo	NNP
cord-000372-wzwpyvll	239	19	synthesized	synthesize	VBD
cord-000372-wzwpyvll	239	20	and	and	CC
cord-000372-wzwpyvll	239	21	preexisting	preexist	VBG
cord-000372-wzwpyvll	239	22	mRNA	mrna	NN
cord-000372-wzwpyvll	239	23	(	(	-LRB-
cord-000372-wzwpyvll	239	24	about	about	RB
cord-000372-wzwpyvll	239	25	40	40	CD
cord-000372-wzwpyvll	239	26	%	%	NN
cord-000372-wzwpyvll	239	27	in	in	IN
cord-000372-wzwpyvll	239	28	both	both	DT
cord-000372-wzwpyvll	239	29	cases	case	NNS
cord-000372-wzwpyvll	239	30	)	)	-RRB-
cord-000372-wzwpyvll	239	31	[	[	-LRB-
cord-000372-wzwpyvll	239	32	96	96	CD
cord-000372-wzwpyvll	239	33	]	]	-RRB-
cord-000372-wzwpyvll	239	34	.	.	.
cord-000372-wzwpyvll	240	1	These	these	DT
cord-000372-wzwpyvll	240	2	findings	finding	NNS
cord-000372-wzwpyvll	240	3	reported	report	VBN
cord-000372-wzwpyvll	240	4	by	by	IN
cord-000372-wzwpyvll	240	5	Welnowska	Welnowska	NNP
cord-000372-wzwpyvll	240	6	and	and	CC
cord-000372-wzwpyvll	240	7	colleagues	colleague	NNS
cord-000372-wzwpyvll	240	8	indicated	indicate	VBD
cord-000372-wzwpyvll	240	9	that	that	IN
cord-000372-wzwpyvll	240	10	the	the	DT
cord-000372-wzwpyvll	240	11	higher	high	JJR
cord-000372-wzwpyvll	240	12	susceptibility	susceptibility	NN
cord-000372-wzwpyvll	240	13	of	of	IN
cord-000372-wzwpyvll	240	14	de	de	NNP
cord-000372-wzwpyvll	240	15	novo	novo	NNP
cord-000372-wzwpyvll	240	16	synthesized	synthesize	VBD
cord-000372-wzwpyvll	240	17	mRNA	mRNA	NNP
cord-000372-wzwpyvll	240	18	translation	translation	NN
cord-000372-wzwpyvll	240	19	to	to	IN
cord-000372-wzwpyvll	240	20	low	low	JJ
cord-000372-wzwpyvll	240	21	doses	dose	NNS
cord-000372-wzwpyvll	240	22	of	of	IN
cord-000372-wzwpyvll	240	23	IRES-2A	IRES-2A	NNP
cord-000372-wzwpyvll	240	24	might	may	MD
cord-000372-wzwpyvll	240	25	be	be	VB
cord-000372-wzwpyvll	240	26	produced	produce	VBN
cord-000372-wzwpyvll	240	27	by	by	IN
cord-000372-wzwpyvll	240	28	an	an	DT
cord-000372-wzwpyvll	240	29	additional	additional	JJ
cord-000372-wzwpyvll	240	30	effect	effect	NN
cord-000372-wzwpyvll	240	31	of	of	IN
cord-000372-wzwpyvll	240	32	PV	PV	NNP
cord-000372-wzwpyvll	240	33	2A	2a	CD
cord-000372-wzwpyvll	240	34	pro	pro	JJ
cord-000372-wzwpyvll	240	35	on	on	IN
cord-000372-wzwpyvll	240	36	another	another	DT
cord-000372-wzwpyvll	240	37	gene	gene	NN
cord-000372-wzwpyvll	240	38	expression	expression	NN
cord-000372-wzwpyvll	240	39	step	step	NN
cord-000372-wzwpyvll	240	40	.	.	.
cord-000372-wzwpyvll	241	1	In	in	IN
cord-000372-wzwpyvll	241	2	this	this	DT
cord-000372-wzwpyvll	241	3	regard	regard	NN
cord-000372-wzwpyvll	241	4	,	,	,
cord-000372-wzwpyvll	241	5	further	further	JJ
cord-000372-wzwpyvll	241	6	studies	study	NNS
cord-000372-wzwpyvll	241	7	demonstrate	demonstrate	VBP
cord-000372-wzwpyvll	241	8	that	that	IN
cord-000372-wzwpyvll	241	9	the	the	DT
cord-000372-wzwpyvll	241	10	stronger	strong	JJR
cord-000372-wzwpyvll	241	11	impact	impact	NN
cord-000372-wzwpyvll	241	12	of	of	IN
cord-000372-wzwpyvll	241	13	2A	2a	CD
cord-000372-wzwpyvll	241	14	pro	pro	NNP
cord-000372-wzwpyvll	241	15	on	on	RP
cord-000372-wzwpyvll	241	16	de	de	IN
cord-000372-wzwpyvll	241	17	novo	novo	NNP
cord-000372-wzwpyvll	241	18	synthesized	synthesize	VBN
cord-000372-wzwpyvll	241	19	mRNAs	mRNAs	NNPS
cord-000372-wzwpyvll	241	20	is	be	VBZ
cord-000372-wzwpyvll	241	21	due	due	JJ
cord-000372-wzwpyvll	241	22	to	to	IN
cord-000372-wzwpyvll	241	23	the	the	DT
cord-000372-wzwpyvll	241	24	concomitant	concomitant	JJ
cord-000372-wzwpyvll	241	25	inhibition	inhibition	NN
cord-000372-wzwpyvll	241	26	of	of	IN
cord-000372-wzwpyvll	241	27	RNA	RNA	NNP
cord-000372-wzwpyvll	241	28	nuclear	nuclear	JJ
cord-000372-wzwpyvll	241	29	export	export	NN
cord-000372-wzwpyvll	241	30	by	by	IN
cord-000372-wzwpyvll	241	31	Nucleoporin	Nucleoporin	NNP
cord-000372-wzwpyvll	241	32	98	98	CD
cord-000372-wzwpyvll	241	33	cleavage	cleavage	NN
cord-000372-wzwpyvll	241	34	,	,	,
cord-000372-wzwpyvll	241	35	which	which	WDT
cord-000372-wzwpyvll	241	36	is	be	VBZ
cord-000372-wzwpyvll	241	37	also	also	RB
cord-000372-wzwpyvll	241	38	achieved	achieve	VBN
cord-000372-wzwpyvll	241	39	under	under	IN
cord-000372-wzwpyvll	241	40	these	these	DT
cord-000372-wzwpyvll	241	41	conditions	condition	NNS
cord-000372-wzwpyvll	241	42	(	(	-LRB-
cord-000372-wzwpyvll	241	43	see	see	VB
cord-000372-wzwpyvll	241	44	below	below	RB
cord-000372-wzwpyvll	241	45	)	)	-RRB-
cord-000372-wzwpyvll	242	1	[	[	-LRB-
cord-000372-wzwpyvll	242	2	17	17	CD
cord-000372-wzwpyvll	242	3	]	]	-RRB-
cord-000372-wzwpyvll	242	4	.	.	.
cord-000372-wzwpyvll	243	1	Interestingly	interestingly	RB
cord-000372-wzwpyvll	243	2	,	,	,
cord-000372-wzwpyvll	243	3	cellular	cellular	JJ
cord-000372-wzwpyvll	243	4	mRNAs	mRNAs	NNPS
cord-000372-wzwpyvll	243	5	are	be	VBP
cord-000372-wzwpyvll	243	6	able	able	JJ
cord-000372-wzwpyvll	243	7	to	to	TO
cord-000372-wzwpyvll	243	8	initiate	initiate	VB
cord-000372-wzwpyvll	243	9	translation	translation	NN
cord-000372-wzwpyvll	243	10	after	after	IN
cord-000372-wzwpyvll	243	11	a	a	DT
cord-000372-wzwpyvll	243	12	polysome	polysome	NN
cord-000372-wzwpyvll	243	13	runoff	runoff	NN
cord-000372-wzwpyvll	243	14	with	with	IN
cord-000372-wzwpyvll	243	15	high	high	JJ
cord-000372-wzwpyvll	243	16	salt	salt	NN
cord-000372-wzwpyvll	243	17	treatment	treatment	NN
cord-000372-wzwpyvll	243	18	when	when	WRB
cord-000372-wzwpyvll	243	19	eIF4GI	eIF4GI	NNS
cord-000372-wzwpyvll	243	20	is	be	VBZ
cord-000372-wzwpyvll	243	21	totally	totally	RB
cord-000372-wzwpyvll	243	22	cleaved	cleave	VBN
cord-000372-wzwpyvll	243	23	by	by	IN
cord-000372-wzwpyvll	243	24	PV	PV	NNP
cord-000372-wzwpyvll	243	25	2A	2a	CD
cord-000372-wzwpyvll	243	26	pro	pro	JJ
cord-000372-wzwpyvll	243	27	,	,	,
cord-000372-wzwpyvll	243	28	whereas	whereas	IN
cord-000372-wzwpyvll	243	29	it	-PRON-	PRP
cord-000372-wzwpyvll	243	30	is	be	VBZ
cord-000372-wzwpyvll	243	31	completely	completely	RB
cord-000372-wzwpyvll	243	32	abolished	abolish	VBN
cord-000372-wzwpyvll	243	33	when	when	WRB
cord-000372-wzwpyvll	243	34	both	both	DT
cord-000372-wzwpyvll	243	35	forms	form	NNS
cord-000372-wzwpyvll	243	36	of	of	IN
cord-000372-wzwpyvll	243	37	eIF4	eIF4	NNP
cord-000372-wzwpyvll	243	38	G	G	NNP
cord-000372-wzwpyvll	243	39	are	be	VBP
cord-000372-wzwpyvll	243	40	proteolyzed	proteolyze	VBN
cord-000372-wzwpyvll	243	41	[	[	-LRB-
cord-000372-wzwpyvll	243	42	95	95	CD
cord-000372-wzwpyvll	243	43	]	]	-RRB-
cord-000372-wzwpyvll	243	44	.	.	.
cord-000372-wzwpyvll	244	1	Taken	take	VBN
cord-000372-wzwpyvll	244	2	together	together	RB
cord-000372-wzwpyvll	244	3	these	these	DT
cord-000372-wzwpyvll	244	4	set	set	NN
cord-000372-wzwpyvll	244	5	of	of	IN
cord-000372-wzwpyvll	244	6	data	datum	NNS
cord-000372-wzwpyvll	244	7	from	from	IN
cord-000372-wzwpyvll	244	8	cell	cell	NN
cord-000372-wzwpyvll	244	9	expressing	express	VBG
cord-000372-wzwpyvll	244	10	2A	2a	CD
cord-000372-wzwpyvll	244	11	pro	pro	JJ
cord-000372-wzwpyvll	244	12	[	[	-LRB-
cord-000372-wzwpyvll	244	13	95	95	CD
cord-000372-wzwpyvll	244	14	,	,	,
cord-000372-wzwpyvll	244	15	136	136	CD
cord-000372-wzwpyvll	244	16	]	]	-RRB-
cord-000372-wzwpyvll	244	17	as	as	RB
cord-000372-wzwpyvll	244	18	well	well	RB
cord-000372-wzwpyvll	244	19	as	as	IN
cord-000372-wzwpyvll	244	20	from	from	IN
cord-000372-wzwpyvll	244	21	PV	pv	NN
cord-000372-wzwpyvll	244	22	-	-	HYPH
cord-000372-wzwpyvll	244	23	infected	infect	VBN
cord-000372-wzwpyvll	244	24	cells	cell	NNS
cord-000372-wzwpyvll	244	25	[	[	-LRB-
cord-000372-wzwpyvll	244	26	120	120	CD
cord-000372-wzwpyvll	244	27	]	]	-RRB-
cord-000372-wzwpyvll	244	28	[	[	-LRB-
cord-000372-wzwpyvll	244	29	121	121	CD
cord-000372-wzwpyvll	244	30	]	]	-RRB-
cord-000372-wzwpyvll	244	31	[	[	-LRB-
cord-000372-wzwpyvll	244	32	122	122	CD
cord-000372-wzwpyvll	244	33	]	]	-RRB-
cord-000372-wzwpyvll	245	1	we	-PRON-	PRP
cord-000372-wzwpyvll	245	2	can	can	MD
cord-000372-wzwpyvll	245	3	conclude	conclude	VB
cord-000372-wzwpyvll	245	4	that	that	IN
cord-000372-wzwpyvll	245	5	complete	complete	JJ
cord-000372-wzwpyvll	245	6	shutoff	shutoff	NN
cord-000372-wzwpyvll	245	7	of	of	IN
cord-000372-wzwpyvll	245	8	the	the	DT
cord-000372-wzwpyvll	245	9	protein	protein	NN
cord-000372-wzwpyvll	245	10	synthesis	synthesis	NN
cord-000372-wzwpyvll	245	11	induced	induce	VBN
cord-000372-wzwpyvll	245	12	by	by	IN
cord-000372-wzwpyvll	245	13	PV	PV	NNP
cord-000372-wzwpyvll	245	14	2A	2a	CD
cord-000372-wzwpyvll	245	15	pro	pro	NNP
cord-000372-wzwpyvll	245	16	is	be	VBZ
cord-000372-wzwpyvll	245	17	achieved	achieve	VBN
cord-000372-wzwpyvll	245	18	when	when	WRB
cord-000372-wzwpyvll	245	19	both	both	DT
cord-000372-wzwpyvll	245	20	eIF4GI	eIF4GI	NNS
cord-000372-wzwpyvll	245	21	and	and	CC
cord-000372-wzwpyvll	245	22	eIF4GII	eIF4GII	NNS
cord-000372-wzwpyvll	245	23	are	be	VBP
cord-000372-wzwpyvll	245	24	completely	completely	RB
cord-000372-wzwpyvll	245	25	cleaved	cleave	VBN
cord-000372-wzwpyvll	245	26	.	.	.
cord-000372-wzwpyvll	246	1	Therefore	therefore	RB
cord-000372-wzwpyvll	246	2	,	,	,
cord-000372-wzwpyvll	246	3	when	when	WRB
cord-000372-wzwpyvll	246	4	the	the	DT
cord-000372-wzwpyvll	246	5	levels	level	NNS
cord-000372-wzwpyvll	246	6	of	of	IN
cord-000372-wzwpyvll	246	7	one	one	CD
cord-000372-wzwpyvll	246	8	of	of	IN
cord-000372-wzwpyvll	246	9	the	the	DT
cord-000372-wzwpyvll	246	10	two	two	CD
cord-000372-wzwpyvll	246	11	populations	population	NNS
cord-000372-wzwpyvll	246	12	of	of	IN
cord-000372-wzwpyvll	246	13	eIF4	eIF4	NNP
cord-000372-wzwpyvll	246	14	G	G	NNP
cord-000372-wzwpyvll	246	15	remain	remain	VBP
cord-000372-wzwpyvll	246	16	unaffected	unaffected	JJ
cord-000372-wzwpyvll	246	17	either	either	CC
cord-000372-wzwpyvll	246	18	because	because	IN
cord-000372-wzwpyvll	246	19	it	-PRON-	PRP
cord-000372-wzwpyvll	246	20	is	be	VBZ
cord-000372-wzwpyvll	246	21	not	not	RB
cord-000372-wzwpyvll	246	22	cleaved	cleave	VBN
cord-000372-wzwpyvll	246	23	by	by	IN
cord-000372-wzwpyvll	246	24	PV	PV	NNP
cord-000372-wzwpyvll	246	25	2A	2a	CD
cord-000372-wzwpyvll	246	26	pro	pro	JJ
cord-000372-wzwpyvll	246	27	[	[	-LRB-
cord-000372-wzwpyvll	246	28	95	95	CD
cord-000372-wzwpyvll	246	29	]	]	-RRB-
cord-000372-wzwpyvll	246	30	or	or	CC
cord-000372-wzwpyvll	246	31	it	-PRON-	PRP
cord-000372-wzwpyvll	246	32	is	be	VBZ
cord-000372-wzwpyvll	246	33	not	not	RB
cord-000372-wzwpyvll	246	34	depleted	deplete	VBN
cord-000372-wzwpyvll	246	35	by	by	IN
cord-000372-wzwpyvll	246	36	siRNAs	siRNAs	NNP
cord-000372-wzwpyvll	246	37	[	[	-LRB-
cord-000372-wzwpyvll	246	38	96	96	CD
cord-000372-wzwpyvll	246	39	]	]	-RRB-
cord-000372-wzwpyvll	247	1	,	,	,
cord-000372-wzwpyvll	247	2	extensive	extensive	JJ
cord-000372-wzwpyvll	247	3	host	host	NN
cord-000372-wzwpyvll	247	4	protein	protein	NN
cord-000372-wzwpyvll	247	5	synthesis	synthesis	NN
cord-000372-wzwpyvll	247	6	takes	take	VBZ
cord-000372-wzwpyvll	247	7	place	place	NN
cord-000372-wzwpyvll	247	8	.	.	.
cord-000372-wzwpyvll	248	1	The	the	DT
cord-000372-wzwpyvll	248	2	infection	infection	NN
cord-000372-wzwpyvll	248	3	of	of	IN
cord-000372-wzwpyvll	248	4	PV	PV	NNP
cord-000372-wzwpyvll	248	5	and	and	CC
cord-000372-wzwpyvll	248	6	coxsackievirus	coxsackievirus	NNP
cord-000372-wzwpyvll	248	7	also	also	RB
cord-000372-wzwpyvll	248	8	leads	lead	VBZ
cord-000372-wzwpyvll	248	9	to	to	IN
cord-000372-wzwpyvll	248	10	hydrolysis	hydrolysis	NN
cord-000372-wzwpyvll	248	11	of	of	IN
cord-000372-wzwpyvll	248	12	PABP	PABP	NNP
cord-000372-wzwpyvll	248	13	[	[	-LRB-
cord-000372-wzwpyvll	248	14	140	140	CD
cord-000372-wzwpyvll	248	15	,	,	,
cord-000372-wzwpyvll	248	16	141	141	CD
cord-000372-wzwpyvll	248	17	]	]	-RRB-
cord-000372-wzwpyvll	248	18	.	.	.
cord-000372-wzwpyvll	249	1	This	this	DT
cord-000372-wzwpyvll	249	2	cleavage	cleavage	NN
cord-000372-wzwpyvll	249	3	is	be	VBZ
cord-000372-wzwpyvll	249	4	carried	carry	VBN
cord-000372-wzwpyvll	249	5	out	out	RP
cord-000372-wzwpyvll	249	6	by	by	IN
cord-000372-wzwpyvll	249	7	PV	PV	NNP
cord-000372-wzwpyvll	249	8	3C	3c	NN
cord-000372-wzwpyvll	249	9	pro	pro	NNP
cord-000372-wzwpyvll	249	10	and	and	CC
cord-000372-wzwpyvll	249	11	coxsackievirus	coxsackievirus	NNP
cord-000372-wzwpyvll	249	12	2A	2A	NNP
cord-000372-wzwpyvll	249	13	pro	pro	NNP
cord-000372-wzwpyvll	249	14	and	and	CC
cord-000372-wzwpyvll	249	15	3C	3C	NNP
cord-000372-wzwpyvll	249	16	pro	pro	NNP
cord-000372-wzwpyvll	250	1	and	and	CC
cord-000372-wzwpyvll	250	2	it	-PRON-	PRP
cord-000372-wzwpyvll	250	3	might	may	MD
cord-000372-wzwpyvll	250	4	actively	actively	RB
cord-000372-wzwpyvll	250	5	contribute	contribute	VB
cord-000372-wzwpyvll	250	6	to	to	IN
cord-000372-wzwpyvll	250	7	the	the	DT
cord-000372-wzwpyvll	250	8	host	host	NN
cord-000372-wzwpyvll	250	9	translational	translational	JJ
cord-000372-wzwpyvll	250	10	shutoff	shutoff	NN
cord-000372-wzwpyvll	250	11	induced	induce	VBN
cord-000372-wzwpyvll	250	12	by	by	IN
cord-000372-wzwpyvll	250	13	these	these	DT
cord-000372-wzwpyvll	250	14	viruses	virus	NNS
cord-000372-wzwpyvll	250	15	[	[	-LRB-
cord-000372-wzwpyvll	250	16	142	142	CD
cord-000372-wzwpyvll	250	17	,	,	,
cord-000372-wzwpyvll	250	18	143	143	CD
cord-000372-wzwpyvll	250	19	]	]	-RRB-
cord-000372-wzwpyvll	250	20	.	.	.
cord-000372-wzwpyvll	251	1	In	in	IN
cord-000372-wzwpyvll	251	2	conclusion	conclusion	NN
cord-000372-wzwpyvll	251	3	,	,	,
cord-000372-wzwpyvll	251	4	the	the	DT
cord-000372-wzwpyvll	251	5	proteolysis	proteolysis	NN
cord-000372-wzwpyvll	251	6	of	of	IN
cord-000372-wzwpyvll	251	7	different	different	JJ
cord-000372-wzwpyvll	251	8	components	component	NNS
cord-000372-wzwpyvll	251	9	of	of	IN
cord-000372-wzwpyvll	251	10	the	the	DT
cord-000372-wzwpyvll	251	11	translation	translation	NN
cord-000372-wzwpyvll	251	12	initiation	initiation	NN
cord-000372-wzwpyvll	251	13	machinery	machinery	NN
cord-000372-wzwpyvll	251	14	by	by	IN
cord-000372-wzwpyvll	251	15	picornavirus	picornavirus	NNP
cord-000372-wzwpyvll	251	16	proteases	protease	NNS
cord-000372-wzwpyvll	251	17	can	can	MD
cord-000372-wzwpyvll	251	18	account	account	VB
cord-000372-wzwpyvll	251	19	for	for	IN
cord-000372-wzwpyvll	251	20	the	the	DT
cord-000372-wzwpyvll	251	21	shutoff	shutoff	NN
cord-000372-wzwpyvll	251	22	of	of	IN
cord-000372-wzwpyvll	251	23	host	host	NN
cord-000372-wzwpyvll	251	24	translation	translation	NN
cord-000372-wzwpyvll	251	25	induced	induce	VBN
cord-000372-wzwpyvll	251	26	after	after	IN
cord-000372-wzwpyvll	251	27	infection	infection	NN
cord-000372-wzwpyvll	251	28	although	although	IN
cord-000372-wzwpyvll	251	29	the	the	DT
cord-000372-wzwpyvll	251	30	specific	specific	JJ
cord-000372-wzwpyvll	251	31	contribution	contribution	NN
cord-000372-wzwpyvll	251	32	of	of	IN
cord-000372-wzwpyvll	251	33	hydrolysis	hydrolysis	NN
cord-000372-wzwpyvll	251	34	of	of	IN
cord-000372-wzwpyvll	251	35	eIF4GI	eIF4GI	NNS
cord-000372-wzwpyvll	251	36	,	,	,
cord-000372-wzwpyvll	251	37	eIF4GII	eif4gii	FW
cord-000372-wzwpyvll	251	38	,	,	,
cord-000372-wzwpyvll	251	39	and	and	CC
cord-000372-wzwpyvll	251	40	PABP	PABP	NNP
cord-000372-wzwpyvll	251	41	remains	remain	VBZ
cord-000372-wzwpyvll	251	42	still	still	RB
cord-000372-wzwpyvll	251	43	unclear	unclear	JJ
cord-000372-wzwpyvll	251	44	.	.	.
cord-000372-wzwpyvll	252	1	Infection	infection	NN
cord-000372-wzwpyvll	252	2	of	of	IN
cord-000372-wzwpyvll	252	3	animal	animal	NN
cord-000372-wzwpyvll	252	4	cells	cell	NNS
cord-000372-wzwpyvll	252	5	with	with	IN
cord-000372-wzwpyvll	252	6	FMDV	FMDV	NNP
cord-000372-wzwpyvll	252	7	also	also	RB
cord-000372-wzwpyvll	252	8	leads	lead	VBZ
cord-000372-wzwpyvll	252	9	to	to	IN
cord-000372-wzwpyvll	252	10	proteolysis	proteolysis	NN
cord-000372-wzwpyvll	252	11	of	of	IN
cord-000372-wzwpyvll	252	12	eIF4	eIF4	NNP
cord-000372-wzwpyvll	252	13	G	G	NNP
cord-000372-wzwpyvll	252	14	and	and	CC
cord-000372-wzwpyvll	252	15	to	to	IN
cord-000372-wzwpyvll	252	16	rapid	rapid	JJ
cord-000372-wzwpyvll	252	17	inhibition	inhibition	NN
cord-000372-wzwpyvll	252	18	of	of	IN
cord-000372-wzwpyvll	252	19	cellular	cellular	JJ
cord-000372-wzwpyvll	252	20	translation	translation	NN
cord-000372-wzwpyvll	252	21	[	[	-LRB-
cord-000372-wzwpyvll	252	22	48	48	CD
cord-000372-wzwpyvll	252	23	]	]	-RRB-
cord-000372-wzwpyvll	252	24	.	.	.
cord-000372-wzwpyvll	253	1	The	the	DT
cord-000372-wzwpyvll	253	2	proteolysis	proteolysis	NN
cord-000372-wzwpyvll	253	3	of	of	IN
cord-000372-wzwpyvll	253	4	eIF4	eIF4	NNP
cord-000372-wzwpyvll	253	5	G	G	NNP
cord-000372-wzwpyvll	253	6	is	be	VBZ
cord-000372-wzwpyvll	253	7	carried	carry	VBN
cord-000372-wzwpyvll	253	8	out	out	RP
cord-000372-wzwpyvll	253	9	by	by	IN
cord-000372-wzwpyvll	253	10	the	the	DT
cord-000372-wzwpyvll	253	11	two	two	CD
cord-000372-wzwpyvll	253	12	virally	virally	RB
cord-000372-wzwpyvll	253	13	encoded	encode	VBN
cord-000372-wzwpyvll	253	14	proteases	protease	NNS
cord-000372-wzwpyvll	253	15	L	L	NNP
cord-000372-wzwpyvll	253	16	pro	pro	NNP
cord-000372-wzwpyvll	253	17	and	and	CC
cord-000372-wzwpyvll	253	18	3C	3C	NNP
cord-000372-wzwpyvll	253	19	pro	pro	NNP
cord-000372-wzwpyvll	253	20	[	[	-LRB-
cord-000372-wzwpyvll	253	21	144	144	CD
cord-000372-wzwpyvll	253	22	,	,	,
cord-000372-wzwpyvll	253	23	145	145	CD
cord-000372-wzwpyvll	253	24	]	]	-RRB-
cord-000372-wzwpyvll	253	25	.	.	.
cord-000372-wzwpyvll	254	1	L	L	NNP
cord-000372-wzwpyvll	254	2	pro	pro	FW
cord-000372-wzwpyvll	254	3	cleaves	cleave	VBZ
cord-000372-wzwpyvll	254	4	both	both	CC
cord-000372-wzwpyvll	254	5	eIF4GI	eIF4GI	NNS
cord-000372-wzwpyvll	254	6	and	and	CC
cord-000372-wzwpyvll	254	7	eIF4GII	eIF4GII	VBZ
cord-000372-wzwpyvll	254	8	extremely	extremely	RB
cord-000372-wzwpyvll	254	9	rapidly	rapidly	RB
cord-000372-wzwpyvll	254	10	at	at	IN
cord-000372-wzwpyvll	254	11	positions	position	NNS
cord-000372-wzwpyvll	254	12	674	674	CD
cord-000372-wzwpyvll	255	1	(	(	-LRB-
cord-000372-wzwpyvll	255	2	Figure	figure	NN
cord-000372-wzwpyvll	255	3	3	3	CD
cord-000372-wzwpyvll	255	4	)	)	-RRB-
cord-000372-wzwpyvll	255	5	and	and	CC
cord-000372-wzwpyvll	255	6	700	700	CD
cord-000372-wzwpyvll	255	7	,	,	,
cord-000372-wzwpyvll	255	8	respectively	respectively	RB
cord-000372-wzwpyvll	255	9	,	,	,
cord-000372-wzwpyvll	255	10	located	locate	VBN
cord-000372-wzwpyvll	255	11	seven	seven	CD
cord-000372-wzwpyvll	255	12	and	and	CC
cord-000372-wzwpyvll	255	13	one	one	CD
cord-000372-wzwpyvll	255	14	amino	amino	NN
cord-000372-wzwpyvll	255	15	acids	acid	NNS
cord-000372-wzwpyvll	255	16	upstream	upstream	RB
cord-000372-wzwpyvll	255	17	of	of	IN
cord-000372-wzwpyvll	255	18	the	the	DT
cord-000372-wzwpyvll	255	19	2A	2a	CD
cord-000372-wzwpyvll	255	20	pro	pro	JJ
cord-000372-wzwpyvll	255	21	cleavage	cleavage	NN
cord-000372-wzwpyvll	255	22	sites	site	NNS
cord-000372-wzwpyvll	255	23	on	on	IN
cord-000372-wzwpyvll	255	24	eIF4GI	eif4gi	NN
cord-000372-wzwpyvll	255	25	and	and	CC
cord-000372-wzwpyvll	255	26	eIF4GII	eif4gii	NN
cord-000372-wzwpyvll	255	27	[	[	-LRB-
cord-000372-wzwpyvll	255	28	50	50	CD
cord-000372-wzwpyvll	255	29	,	,	,
cord-000372-wzwpyvll	255	30	146	146	CD
cord-000372-wzwpyvll	255	31	]	]	-RRB-
cord-000372-wzwpyvll	255	32	.	.	.
cord-000372-wzwpyvll	256	1	The	the	DT
cord-000372-wzwpyvll	256	2	cleavage	cleavage	NN
cord-000372-wzwpyvll	256	3	of	of	IN
cord-000372-wzwpyvll	256	4	eIF4	eIF4	NNP
cord-000372-wzwpyvll	256	5	G	G	NNP
cord-000372-wzwpyvll	256	6	by	by	IN
cord-000372-wzwpyvll	256	7	FMDV	FMDV	NNP
cord-000372-wzwpyvll	256	8	L	L	NNP
cord-000372-wzwpyvll	256	9	pro	pro	JJ
cord-000372-wzwpyvll	256	10	results	result	NNS
cord-000372-wzwpyvll	256	11	in	in	IN
cord-000372-wzwpyvll	256	12	the	the	DT
cord-000372-wzwpyvll	256	13	rapid	rapid	JJ
cord-000372-wzwpyvll	256	14	shutoff	shutoff	NN
cord-000372-wzwpyvll	256	15	of	of	IN
cord-000372-wzwpyvll	256	16	host	host	NN
cord-000372-wzwpyvll	256	17	-	-	HYPH
cord-000372-wzwpyvll	256	18	cell	cell	NN
cord-000372-wzwpyvll	256	19	protein	protein	NN
cord-000372-wzwpyvll	256	20	synthesis	synthesis	NN
cord-000372-wzwpyvll	256	21	[	[	-LRB-
cord-000372-wzwpyvll	256	22	145	145	CD
cord-000372-wzwpyvll	256	23	]	]	-RRB-
cord-000372-wzwpyvll	256	24	.	.	.
cord-000372-wzwpyvll	257	1	Although	although	IN
cord-000372-wzwpyvll	257	2	the	the	DT
cord-000372-wzwpyvll	257	3	initial	initial	JJ
cord-000372-wzwpyvll	257	4	cleavage	cleavage	NN
cord-000372-wzwpyvll	257	5	of	of	IN
cord-000372-wzwpyvll	257	6	eIF4GI	eIF4GI	NNS
cord-000372-wzwpyvll	257	7	can	can	MD
cord-000372-wzwpyvll	257	8	be	be	VB
cord-000372-wzwpyvll	257	9	carried	carry	VBN
cord-000372-wzwpyvll	257	10	out	out	RP
cord-000372-wzwpyvll	257	11	by	by	IN
cord-000372-wzwpyvll	257	12	FMDV	FMDV	NNP
cord-000372-wzwpyvll	257	13	L	L	NNP
cord-000372-wzwpyvll	257	14	pro	pro	FW
cord-000372-wzwpyvll	257	15	in	in	IN
cord-000372-wzwpyvll	257	16	the	the	DT
cord-000372-wzwpyvll	257	17	absence	absence	NN
cord-000372-wzwpyvll	257	18	of	of	IN
cord-000372-wzwpyvll	257	19	virus	virus	NN
cord-000372-wzwpyvll	257	20	replication	replication	NN
cord-000372-wzwpyvll	257	21	[	[	-LRB-
cord-000372-wzwpyvll	257	22	145	145	CD
cord-000372-wzwpyvll	257	23	]	]	-RRB-
cord-000372-wzwpyvll	257	24	,	,	,
cord-000372-wzwpyvll	257	25	a	a	DT
cord-000372-wzwpyvll	257	26	sequential	sequential	JJ
cord-000372-wzwpyvll	257	27	cleavage	cleavage	NN
cord-000372-wzwpyvll	257	28	of	of	IN
cord-000372-wzwpyvll	257	29	the	the	DT
cord-000372-wzwpyvll	257	30	C	C	NNP
cord-000372-wzwpyvll	257	31	-	-	HYPH
cord-000372-wzwpyvll	257	32	terminal	terminal	NN
cord-000372-wzwpyvll	257	33	fragment	fragment	NN
cord-000372-wzwpyvll	257	34	of	of	IN
cord-000372-wzwpyvll	257	35	eIF4GI	eIF4GI	NNS
cord-000372-wzwpyvll	257	36	by	by	IN
cord-000372-wzwpyvll	257	37	FMDV	FMDV	NNP
cord-000372-wzwpyvll	257	38	3C	3C	NNP
cord-000372-wzwpyvll	257	39	pro	pro	JJ
cord-000372-wzwpyvll	257	40	also	also	RB
cord-000372-wzwpyvll	257	41	occurs	occur	VBZ
cord-000372-wzwpyvll	257	42	in	in	IN
cord-000372-wzwpyvll	257	43	BHK	BHK	NNP
cord-000372-wzwpyvll	257	44	cells	cell	NNS
cord-000372-wzwpyvll	257	45	at	at	IN
cord-000372-wzwpyvll	257	46	early	early	JJ
cord-000372-wzwpyvll	257	47	stages	stage	NNS
cord-000372-wzwpyvll	257	48	of	of	IN
cord-000372-wzwpyvll	257	49	infection	infection	NN
cord-000372-wzwpyvll	257	50	concomitant	concomitant	JJ
cord-000372-wzwpyvll	257	51	with	with	IN
cord-000372-wzwpyvll	257	52	the	the	DT
cord-000372-wzwpyvll	257	53	shutdown	shutdown	NN
cord-000372-wzwpyvll	257	54	of	of	IN
cord-000372-wzwpyvll	257	55	viral	viral	JJ
cord-000372-wzwpyvll	257	56	translation	translation	NN
cord-000372-wzwpyvll	257	57	.	.	.
cord-000372-wzwpyvll	258	1	The	the	DT
cord-000372-wzwpyvll	258	2	3C	3c	NN
cord-000372-wzwpyvll	258	3	pro	pro	JJ
cord-000372-wzwpyvll	258	4	cleavage	cleavage	NN
cord-000372-wzwpyvll	258	5	site	site	NN
cord-000372-wzwpyvll	258	6	on	on	IN
cord-000372-wzwpyvll	258	7	eIF4GI	eIF4GI	NNS
cord-000372-wzwpyvll	258	8	has	have	VBZ
cord-000372-wzwpyvll	258	9	been	be	VBN
cord-000372-wzwpyvll	258	10	located	locate	VBN
cord-000372-wzwpyvll	258	11	at	at	IN
cord-000372-wzwpyvll	258	12	position	position	NN
cord-000372-wzwpyvll	258	13	712	712	CD
cord-000372-wzwpyvll	258	14	,	,	,
cord-000372-wzwpyvll	258	15	38	38	CD
cord-000372-wzwpyvll	258	16	amino	amino	NN
cord-000372-wzwpyvll	258	17	acids	acid	NNS
cord-000372-wzwpyvll	258	18	downstream	downstream	RB
cord-000372-wzwpyvll	258	19	of	of	IN
cord-000372-wzwpyvll	258	20	the	the	DT
cord-000372-wzwpyvll	258	21	L	l	NN
cord-000372-wzwpyvll	258	22	pro	pro	JJ
cord-000372-wzwpyvll	258	23	cleavage	cleavage	NN
cord-000372-wzwpyvll	258	24	site	site	NN
cord-000372-wzwpyvll	258	25	[	[	-LRB-
cord-000372-wzwpyvll	258	26	147	147	CD
cord-000372-wzwpyvll	258	27	]	]	-RRB-
cord-000372-wzwpyvll	258	28	although	although	IN
cord-000372-wzwpyvll	258	29	the	the	DT
cord-000372-wzwpyvll	258	30	role	role	NN
cord-000372-wzwpyvll	258	31	of	of	IN
cord-000372-wzwpyvll	258	32	this	this	DT
cord-000372-wzwpyvll	258	33	sequential	sequential	JJ
cord-000372-wzwpyvll	258	34	cleavage	cleavage	NN
cord-000372-wzwpyvll	258	35	is	be	VBZ
cord-000372-wzwpyvll	258	36	still	still	RB
cord-000372-wzwpyvll	258	37	unclear	unclear	JJ
cord-000372-wzwpyvll	258	38	.	.	.
cord-000372-wzwpyvll	259	1	The	the	DT
cord-000372-wzwpyvll	259	2	amino	amino	NN
cord-000372-wzwpyvll	259	3	acid	acid	NN
cord-000372-wzwpyvll	259	4	segment	segment	NN
cord-000372-wzwpyvll	259	5	of	of	IN
cord-000372-wzwpyvll	259	6	eIF4	eIF4	NNP
cord-000372-wzwpyvll	259	7	G	G	NNP
cord-000372-wzwpyvll	259	8	located	locate	VBN
cord-000372-wzwpyvll	259	9	between	between	IN
cord-000372-wzwpyvll	259	10	the	the	DT
cord-000372-wzwpyvll	259	11	L	L	NNP
cord-000372-wzwpyvll	259	12	pro	pro	NNP
cord-000372-wzwpyvll	259	13	and	and	CC
cord-000372-wzwpyvll	259	14	3C	3c	NN
cord-000372-wzwpyvll	259	15	pro	pro	JJ
cord-000372-wzwpyvll	259	16	cleavage	cleavage	NN
cord-000372-wzwpyvll	259	17	sites	site	NNS
cord-000372-wzwpyvll	259	18	binds	bind	VBZ
cord-000372-wzwpyvll	259	19	RNA	RNA	NNP
cord-000372-wzwpyvll	259	20	and	and	CC
cord-000372-wzwpyvll	259	21	was	be	VBD
cord-000372-wzwpyvll	259	22	suggested	suggest	VBN
cord-000372-wzwpyvll	259	23	to	to	TO
cord-000372-wzwpyvll	259	24	be	be	VB
cord-000372-wzwpyvll	259	25	critical	critical	JJ
cord-000372-wzwpyvll	259	26	for	for	IN
cord-000372-wzwpyvll	259	27	mRNA	mrna	NN
cord-000372-wzwpyvll	259	28	scanning	scan	VBG
cord-000372-wzwpyvll	259	29	by	by	IN
cord-000372-wzwpyvll	259	30	the	the	DT
cord-000372-wzwpyvll	259	31	preinitiation	preinitiation	NN
cord-000372-wzwpyvll	259	32	complex	complex	NN
cord-000372-wzwpyvll	259	33	[	[	-LRB-
cord-000372-wzwpyvll	259	34	148	148	CD
cord-000372-wzwpyvll	259	35	]	]	-RRB-
cord-000372-wzwpyvll	259	36	.	.	.
cord-000372-wzwpyvll	260	1	Interestingly	interestingly	RB
cord-000372-wzwpyvll	260	2	,	,	,
cord-000372-wzwpyvll	260	3	this	this	DT
cord-000372-wzwpyvll	260	4	secondary	secondary	JJ
cord-000372-wzwpyvll	260	5	cleavage	cleavage	NN
cord-000372-wzwpyvll	260	6	does	do	VBZ
cord-000372-wzwpyvll	260	7	not	not	RB
cord-000372-wzwpyvll	260	8	occur	occur	VB
cord-000372-wzwpyvll	260	9	in	in	IN
cord-000372-wzwpyvll	260	10	human	human	JJ
cord-000372-wzwpyvll	260	11	cell	cell	NN
cord-000372-wzwpyvll	260	12	lines	line	NNS
cord-000372-wzwpyvll	260	13	due	due	JJ
cord-000372-wzwpyvll	260	14	to	to	IN
cord-000372-wzwpyvll	260	15	an	an	DT
cord-000372-wzwpyvll	260	16	amino	amino	NN
cord-000372-wzwpyvll	260	17	acid	acid	NN
cord-000372-wzwpyvll	260	18	substitution	substitution	NN
cord-000372-wzwpyvll	260	19	at	at	IN
cord-000372-wzwpyvll	260	20	the	the	DT
cord-000372-wzwpyvll	260	21	cleavage	cleavage	NN
cord-000372-wzwpyvll	260	22	site	site	NN
cord-000372-wzwpyvll	260	23	on	on	IN
cord-000372-wzwpyvll	260	24	eIF4GI	eif4gi	CD
cord-000372-wzwpyvll	260	25	[	[	-LRB-
cord-000372-wzwpyvll	260	26	147	147	CD
cord-000372-wzwpyvll	260	27	]	]	-RRB-
cord-000372-wzwpyvll	260	28	.	.	.
cord-000372-wzwpyvll	261	1	Infection	infection	NN
cord-000372-wzwpyvll	261	2	of	of	IN
cord-000372-wzwpyvll	261	3	cells	cell	NNS
cord-000372-wzwpyvll	261	4	with	with	IN
cord-000372-wzwpyvll	261	5	other	other	JJ
cord-000372-wzwpyvll	261	6	picornaviruses	picornavirus	NNS
cord-000372-wzwpyvll	261	7	such	such	JJ
cord-000372-wzwpyvll	261	8	as	as	IN
cord-000372-wzwpyvll	261	9	cardioviruses	cardioviruse	NNS
cord-000372-wzwpyvll	261	10	(	(	-LRB-
cord-000372-wzwpyvll	261	11	EMCV	EMCV	NNP
cord-000372-wzwpyvll	261	12	and	and	CC
cord-000372-wzwpyvll	261	13	mengovirus	mengovirus	NNP
cord-000372-wzwpyvll	261	14	)	)	-RRB-
cord-000372-wzwpyvll	261	15	leads	lead	VBZ
cord-000372-wzwpyvll	261	16	to	to	IN
cord-000372-wzwpyvll	261	17	a	a	DT
cord-000372-wzwpyvll	261	18	shutoff	shutoff	NN
cord-000372-wzwpyvll	261	19	of	of	IN
cord-000372-wzwpyvll	261	20	host	host	NN
cord-000372-wzwpyvll	261	21	-	-	HYPH
cord-000372-wzwpyvll	261	22	cell	cell	NN
cord-000372-wzwpyvll	261	23	protein	protein	NN
cord-000372-wzwpyvll	261	24	synthesis	synthesis	NN
cord-000372-wzwpyvll	261	25	.	.	.
cord-000372-wzwpyvll	262	1	However	however	RB
cord-000372-wzwpyvll	262	2	,	,	,
cord-000372-wzwpyvll	262	3	eIF4	eIF4	NNP
cord-000372-wzwpyvll	262	4	G	G	NNP
cord-000372-wzwpyvll	262	5	remains	remain	VBZ
cord-000372-wzwpyvll	262	6	unaffected	unaffected	JJ
cord-000372-wzwpyvll	262	7	in	in	IN
cord-000372-wzwpyvll	262	8	these	these	DT
cord-000372-wzwpyvll	262	9	cells	cell	NNS
cord-000372-wzwpyvll	262	10	.	.	.
cord-000372-wzwpyvll	263	1	These	these	DT
cord-000372-wzwpyvll	263	2	findings	finding	NNS
cord-000372-wzwpyvll	263	3	indicate	indicate	VBP
cord-000372-wzwpyvll	263	4	that	that	IN
cord-000372-wzwpyvll	263	5	apart	apart	RB
cord-000372-wzwpyvll	263	6	from	from	IN
cord-000372-wzwpyvll	263	7	eIF4	eIF4	NNP
cord-000372-wzwpyvll	263	8	G	g	NN
cord-000372-wzwpyvll	263	9	cleavage	cleavage	NN
cord-000372-wzwpyvll	263	10	,	,	,
cord-000372-wzwpyvll	263	11	there	there	EX
cord-000372-wzwpyvll	263	12	are	be	VBP
cord-000372-wzwpyvll	263	13	other	other	JJ
cord-000372-wzwpyvll	263	14	mechanisms	mechanism	NNS
cord-000372-wzwpyvll	263	15	that	that	WDT
cord-000372-wzwpyvll	263	16	may	may	MD
cord-000372-wzwpyvll	263	17	block	block	VB
cord-000372-wzwpyvll	263	18	host	host	NN
cord-000372-wzwpyvll	263	19	translation	translation	NN
cord-000372-wzwpyvll	263	20	by	by	IN
cord-000372-wzwpyvll	263	21	picornaviruses	picornavirus	NNS
cord-000372-wzwpyvll	263	22	.	.	.
cord-000372-wzwpyvll	264	1	In	in	IN
cord-000372-wzwpyvll	264	2	addition	addition	NN
cord-000372-wzwpyvll	264	3	to	to	IN
cord-000372-wzwpyvll	264	4	picornavirus	picornavirus	NNP
cord-000372-wzwpyvll	264	5	L	L	NNP
cord-000372-wzwpyvll	264	6	pro	pro	NNP
cord-000372-wzwpyvll	264	7	and	and	CC
cord-000372-wzwpyvll	264	8	2A	2a	CD
cord-000372-wzwpyvll	264	9	pro	pro	JJ
cord-000372-wzwpyvll	264	10	,	,	,
cord-000372-wzwpyvll	264	11	proteases	protease	NNS
cord-000372-wzwpyvll	264	12	from	from	IN
cord-000372-wzwpyvll	264	13	other	other	JJ
cord-000372-wzwpyvll	264	14	viruses	virus	NNS
cord-000372-wzwpyvll	264	15	can	can	MD
cord-000372-wzwpyvll	264	16	also	also	RB
cord-000372-wzwpyvll	264	17	cleave	cleave	VB
cord-000372-wzwpyvll	264	18	eIF4G.	eIF4G.	.
cord-000372-wzwpyvll	265	1	The	the	DT
cord-000372-wzwpyvll	265	2	protease	protease	NN
cord-000372-wzwpyvll	265	3	of	of	IN
cord-000372-wzwpyvll	265	4	human	human	JJ
cord-000372-wzwpyvll	265	5	immunodeficiency	immunodeficiency	NN
cord-000372-wzwpyvll	265	6	virus	virus	NN
cord-000372-wzwpyvll	265	7	type-1	type-1	NNP
cord-000372-wzwpyvll	265	8	(	(	-LRB-
cord-000372-wzwpyvll	265	9	HIV-1	HIV-1	NNP
cord-000372-wzwpyvll	265	10	)	)	-RRB-
cord-000372-wzwpyvll	265	11	hydrolyzes	hydrolyze	VBZ
cord-000372-wzwpyvll	265	12	eIF4GI	eIF4GI	NNS
cord-000372-wzwpyvll	265	13	during	during	IN
cord-000372-wzwpyvll	265	14	infection	infection	NN
cord-000372-wzwpyvll	265	15	of	of	IN
cord-000372-wzwpyvll	265	16	human	human	JJ
cord-000372-wzwpyvll	265	17	CD4	CD4	NNP
cord-000372-wzwpyvll	265	18	+	+	CC
cord-000372-wzwpyvll	265	19	cells	cell	NNS
cord-000372-wzwpyvll	265	20	[	[	-LRB-
cord-000372-wzwpyvll	265	21	149	149	CD
cord-000372-wzwpyvll	265	22	]	]	-RRB-
cord-000372-wzwpyvll	265	23	.	.	.
cord-000372-wzwpyvll	266	1	The	the	DT
cord-000372-wzwpyvll	266	2	cleavage	cleavage	NN
cord-000372-wzwpyvll	266	3	of	of	IN
cord-000372-wzwpyvll	266	4	eIF4GI	eif4gi	DT
cord-000372-wzwpyvll	266	5	takes	take	VBZ
cord-000372-wzwpyvll	266	6	place	place	NN
cord-000372-wzwpyvll	266	7	at	at	IN
cord-000372-wzwpyvll	266	8	positions	position	NNS
cord-000372-wzwpyvll	266	9	718	718	CD
cord-000372-wzwpyvll	266	10	,	,	,
cord-000372-wzwpyvll	266	11	721	721	CD
cord-000372-wzwpyvll	266	12	,	,	,
cord-000372-wzwpyvll	266	13	and	and	CC
cord-000372-wzwpyvll	266	14	Journal	Journal	NNP
cord-000372-wzwpyvll	266	15	of	of	IN
cord-000372-wzwpyvll	266	16	Biomedicine	Biomedicine	NNP
cord-000372-wzwpyvll	266	17	and	and	CC
cord-000372-wzwpyvll	266	18	Biotechnology	Biotechnology	NNP
cord-000372-wzwpyvll	266	19	9	9	CD
cord-000372-wzwpyvll	266	20	1125	1125	CD
cord-000372-wzwpyvll	266	21	,	,	,
cord-000372-wzwpyvll	266	22	separating	separate	VBG
cord-000372-wzwpyvll	266	23	it	-PRON-	PRP
cord-000372-wzwpyvll	266	24	in	in	IN
cord-000372-wzwpyvll	266	25	three	three	CD
cord-000372-wzwpyvll	266	26	domains	domain	NNS
cord-000372-wzwpyvll	266	27	(	(	-LRB-
cord-000372-wzwpyvll	266	28	Figure	figure	NN
cord-000372-wzwpyvll	266	29	3	3	CD
cord-000372-wzwpyvll	266	30	)	)	-RRB-
cord-000372-wzwpyvll	266	31	[	[	-LRB-
cord-000372-wzwpyvll	266	32	149	149	CD
cord-000372-wzwpyvll	266	33	,	,	,
cord-000372-wzwpyvll	266	34	150	150	CD
cord-000372-wzwpyvll	266	35	]	]	-RRB-
cord-000372-wzwpyvll	266	36	.	.	.
cord-000372-wzwpyvll	267	1	Interestingly	interestingly	RB
cord-000372-wzwpyvll	267	2	,	,	,
cord-000372-wzwpyvll	267	3	HIV-1	HIV-1	NNP
cord-000372-wzwpyvll	267	4	protease	protease	NN
cord-000372-wzwpyvll	267	5	efficiently	efficiently	RB
cord-000372-wzwpyvll	267	6	cleaves	cleave	VBZ
cord-000372-wzwpyvll	267	7	eIF4GI	eIF4GI	NNS
cord-000372-wzwpyvll	267	8	,	,	,
cord-000372-wzwpyvll	267	9	but	but	CC
cord-000372-wzwpyvll	267	10	not	not	RB
cord-000372-wzwpyvll	267	11	eIF4GII	eif4gii	NN
cord-000372-wzwpyvll	267	12	,	,	,
cord-000372-wzwpyvll	267	13	both	both	CC
cord-000372-wzwpyvll	267	14	in	in	IN
cord-000372-wzwpyvll	267	15	cell	cell	NN
cord-000372-wzwpyvll	267	16	-	-	HYPH
cord-000372-wzwpyvll	267	17	free	free	JJ
cord-000372-wzwpyvll	267	18	systems	system	NNS
cord-000372-wzwpyvll	267	19	and	and	CC
cord-000372-wzwpyvll	267	20	in	in	IN
cord-000372-wzwpyvll	267	21	mammalian	mammalian	JJ
cord-000372-wzwpyvll	267	22	cells	cell	NNS
cord-000372-wzwpyvll	267	23	[	[	-LRB-
cord-000372-wzwpyvll	267	24	151	151	CD
cord-000372-wzwpyvll	267	25	]	]	-RRB-
cord-000372-wzwpyvll	267	26	.	.	.
cord-000372-wzwpyvll	268	1	The	the	DT
cord-000372-wzwpyvll	268	2	differential	differential	JJ
cord-000372-wzwpyvll	268	3	sensitivity	sensitivity	NN
cord-000372-wzwpyvll	268	4	of	of	IN
cord-000372-wzwpyvll	268	5	eIF4GI	eif4gi	NN
cord-000372-wzwpyvll	268	6	and	and	CC
cord-000372-wzwpyvll	268	7	eIF4GII	eIF4GII	VBZ
cord-000372-wzwpyvll	268	8	to	to	IN
cord-000372-wzwpyvll	268	9	HIV-1	HIV-1	NNP
cord-000372-wzwpyvll	268	10	protease	protease	NN
cord-000372-wzwpyvll	268	11	is	be	VBZ
cord-000372-wzwpyvll	268	12	more	more	RBR
cord-000372-wzwpyvll	268	13	selective	selective	JJ
cord-000372-wzwpyvll	268	14	than	than	IN
cord-000372-wzwpyvll	268	15	that	that	DT
cord-000372-wzwpyvll	268	16	observed	observe	VBN
cord-000372-wzwpyvll	268	17	with	with	IN
cord-000372-wzwpyvll	268	18	picornaviral	picornaviral	NNP
cord-000372-wzwpyvll	268	19	2A	2A	NNP
cord-000372-wzwpyvll	268	20	proteases	protease	NNS
cord-000372-wzwpyvll	268	21	[	[	-LRB-
cord-000372-wzwpyvll	268	22	122	122	CD
cord-000372-wzwpyvll	268	23	,	,	,
cord-000372-wzwpyvll	268	24	123	123	CD
cord-000372-wzwpyvll	268	25	]	]	-RRB-
cord-000372-wzwpyvll	268	26	.	.	.
cord-000372-wzwpyvll	269	1	HIV-1	HIV-1	NNP
cord-000372-wzwpyvll	269	2	protease	protease	NN
cord-000372-wzwpyvll	269	3	also	also	RB
cord-000372-wzwpyvll	269	4	cleaves	cleave	VBZ
cord-000372-wzwpyvll	269	5	PABP	PABP	NNP
cord-000372-wzwpyvll	269	6	at	at	IN
cord-000372-wzwpyvll	269	7	positions	position	NNS
cord-000372-wzwpyvll	269	8	237	237	CD
cord-000372-wzwpyvll	269	9	and	and	CC
cord-000372-wzwpyvll	269	10	477	477	CD
cord-000372-wzwpyvll	269	11	separating	separate	VBG
cord-000372-wzwpyvll	269	12	the	the	DT
cord-000372-wzwpyvll	269	13	two	two	CD
cord-000372-wzwpyvll	269	14	first	first	JJ
cord-000372-wzwpyvll	269	15	RNA	RNA	NNP
cord-000372-wzwpyvll	269	16	-	-	HYPH
cord-000372-wzwpyvll	269	17	recognition	recognition	NN
cord-000372-wzwpyvll	269	18	motifs	motif	NNS
cord-000372-wzwpyvll	269	19	from	from	IN
cord-000372-wzwpyvll	269	20	the	the	DT
cord-000372-wzwpyvll	269	21	C	C	NNP
cord-000372-wzwpyvll	269	22	-	-	HYPH
cord-000372-wzwpyvll	269	23	terminal	terminal	NN
cord-000372-wzwpyvll	269	24	domain	domain	NN
cord-000372-wzwpyvll	269	25	of	of	IN
cord-000372-wzwpyvll	269	26	PABP	PABP	NNP
cord-000372-wzwpyvll	269	27	[	[	-LRB-
cord-000372-wzwpyvll	269	28	152	152	CD
cord-000372-wzwpyvll	269	29	]	]	-RRB-
cord-000372-wzwpyvll	269	30	.	.	.
cord-000372-wzwpyvll	270	1	Cleavage	cleavage	NN
cord-000372-wzwpyvll	270	2	of	of	IN
cord-000372-wzwpyvll	270	3	eIF4GI	eif4gi	NN
cord-000372-wzwpyvll	270	4	and	and	CC
cord-000372-wzwpyvll	270	5	PABP	PABP	NNP
cord-000372-wzwpyvll	270	6	by	by	IN
cord-000372-wzwpyvll	270	7	HIV-1	HIV-1	NNP
cord-000372-wzwpyvll	270	8	protease	protease	NN
cord-000372-wzwpyvll	270	9	is	be	VBZ
cord-000372-wzwpyvll	270	10	sufficient	sufficient	JJ
cord-000372-wzwpyvll	270	11	to	to	TO
cord-000372-wzwpyvll	270	12	inhibit	inhibit	VB
cord-000372-wzwpyvll	270	13	the	the	DT
cord-000372-wzwpyvll	270	14	translation	translation	NN
cord-000372-wzwpyvll	270	15	of	of	IN
cord-000372-wzwpyvll	270	16	capped	capped	JJ
cord-000372-wzwpyvll	270	17	and	and	CC
cord-000372-wzwpyvll	270	18	polyadenylated	polyadenylate	VBN
cord-000372-wzwpyvll	270	19	mRNAs	mRNAs	-RRB-
cord-000372-wzwpyvll	270	20	in	in	IN
cord-000372-wzwpyvll	270	21	cell	cell	NN
cord-000372-wzwpyvll	270	22	-	-	HYPH
cord-000372-wzwpyvll	270	23	free	free	JJ
cord-000372-wzwpyvll	270	24	systems	system	NNS
cord-000372-wzwpyvll	270	25	,	,	,
cord-000372-wzwpyvll	270	26	as	as	RB
cord-000372-wzwpyvll	270	27	well	well	RB
cord-000372-wzwpyvll	270	28	as	as	IN
cord-000372-wzwpyvll	270	29	in	in	IN
cord-000372-wzwpyvll	270	30	transfected	transfecte	VBN
cord-000372-wzwpyvll	270	31	cells	cell	NNS
cord-000372-wzwpyvll	270	32	[	[	-LRB-
cord-000372-wzwpyvll	270	33	127	127	CD
cord-000372-wzwpyvll	270	34	,	,	,
cord-000372-wzwpyvll	270	35	151	151	CD
cord-000372-wzwpyvll	270	36	]	]	-RRB-
cord-000372-wzwpyvll	270	37	.	.	.
cord-000372-wzwpyvll	271	1	In	in	IN
cord-000372-wzwpyvll	271	2	contrast	contrast	NN
cord-000372-wzwpyvll	271	3	,	,	,
cord-000372-wzwpyvll	271	4	IRES	IRES	NNP
cord-000372-wzwpyvll	271	5	-	-	HYPH
cord-000372-wzwpyvll	271	6	driven	drive	VBN
cord-000372-wzwpyvll	271	7	translation	translation	NN
cord-000372-wzwpyvll	271	8	is	be	VBZ
cord-000372-wzwpyvll	271	9	unaffected	unaffected	JJ
cord-000372-wzwpyvll	271	10	or	or	CC
cord-000372-wzwpyvll	271	11	even	even	RB
cord-000372-wzwpyvll	271	12	enhanced	enhance	VBN
cord-000372-wzwpyvll	271	13	by	by	IN
cord-000372-wzwpyvll	271	14	HIV-1	HIV-1	NNP
cord-000372-wzwpyvll	271	15	PR	PR	NNP
cord-000372-wzwpyvll	271	16	after	after	IN
cord-000372-wzwpyvll	271	17	cleavage	cleavage	NN
cord-000372-wzwpyvll	271	18	of	of	IN
cord-000372-wzwpyvll	271	19	both	both	DT
cord-000372-wzwpyvll	271	20	eIF4GI	eIF4GI	NNS
cord-000372-wzwpyvll	271	21	and	and	CC
cord-000372-wzwpyvll	271	22	PABP	PABP	NNP
cord-000372-wzwpyvll	271	23	[	[	-LRB-
cord-000372-wzwpyvll	271	24	127	127	CD
cord-000372-wzwpyvll	271	25	,	,	,
cord-000372-wzwpyvll	271	26	151	151	CD
cord-000372-wzwpyvll	271	27	]	]	-RRB-
cord-000372-wzwpyvll	271	28	.	.	.
cord-000372-wzwpyvll	272	1	Moreover	moreover	RB
cord-000372-wzwpyvll	272	2	,	,	,
cord-000372-wzwpyvll	272	3	the	the	DT
cord-000372-wzwpyvll	272	4	translation	translation	NN
cord-000372-wzwpyvll	272	5	of	of	IN
cord-000372-wzwpyvll	272	6	capped	capped	JJ
cord-000372-wzwpyvll	272	7	and	and	CC
cord-000372-wzwpyvll	272	8	polyadenylated	polyadenylate	VBD
cord-000372-wzwpyvll	272	9	HIV-1	HIV-1	NNP
cord-000372-wzwpyvll	272	10	genomic	genomic	NN
cord-000372-wzwpyvll	272	11	mRNA	mrna	NN
cord-000372-wzwpyvll	272	12	remains	remain	VBZ
cord-000372-wzwpyvll	272	13	unaffected	unaffected	JJ
cord-000372-wzwpyvll	272	14	in	in	IN
cord-000372-wzwpyvll	272	15	HeLa	HeLa	NNP
cord-000372-wzwpyvll	272	16	extracts	extract	NNS
cord-000372-wzwpyvll	272	17	under	under	IN
cord-000372-wzwpyvll	272	18	these	these	DT
cord-000372-wzwpyvll	272	19	conditions	condition	NNS
cord-000372-wzwpyvll	272	20	suggesting	suggest	VBG
cord-000372-wzwpyvll	272	21	that	that	IN
cord-000372-wzwpyvll	272	22	viral	viral	JJ
cord-000372-wzwpyvll	272	23	protein	protein	NN
cord-000372-wzwpyvll	272	24	synthesis	synthesis	NN
cord-000372-wzwpyvll	272	25	might	may	MD
cord-000372-wzwpyvll	272	26	persist	persist	VB
cord-000372-wzwpyvll	272	27	at	at	IN
cord-000372-wzwpyvll	272	28	late	late	JJ
cord-000372-wzwpyvll	272	29	phases	phase	NNS
cord-000372-wzwpyvll	272	30	of	of	IN
cord-000372-wzwpyvll	272	31	HIV-1	HIV-1	NNP
cord-000372-wzwpyvll	272	32	infection	infection	NN
cord-000372-wzwpyvll	272	33	where	where	WRB
cord-000372-wzwpyvll	272	34	those	those	DT
cord-000372-wzwpyvll	272	35	factors	factor	NNS
cord-000372-wzwpyvll	272	36	are	be	VBP
cord-000372-wzwpyvll	272	37	cleaved	cleave	VBN
cord-000372-wzwpyvll	272	38	[	[	-LRB-
cord-000372-wzwpyvll	272	39	127	127	CD
cord-000372-wzwpyvll	272	40	]	]	-RRB-
cord-000372-wzwpyvll	272	41	.	.	.
cord-000372-wzwpyvll	273	1	In	in	IN
cord-000372-wzwpyvll	273	2	contrast	contrast	NN
cord-000372-wzwpyvll	273	3	,	,	,
cord-000372-wzwpyvll	273	4	a	a	DT
cord-000372-wzwpyvll	273	5	previous	previous	JJ
cord-000372-wzwpyvll	273	6	report	report	NN
cord-000372-wzwpyvll	273	7	claimed	claim	VBD
cord-000372-wzwpyvll	273	8	that	that	IN
cord-000372-wzwpyvll	273	9	the	the	DT
cord-000372-wzwpyvll	273	10	hydrolysis	hydrolysis	NN
cord-000372-wzwpyvll	273	11	of	of	IN
cord-000372-wzwpyvll	273	12	eIF4GI	eif4gi	RB
cord-000372-wzwpyvll	273	13	impaired	impair	VBD
cord-000372-wzwpyvll	273	14	the	the	DT
cord-000372-wzwpyvll	273	15	translation	translation	NN
cord-000372-wzwpyvll	273	16	of	of	IN
cord-000372-wzwpyvll	273	17	both	both	CC
cord-000372-wzwpyvll	273	18	capped	capped	JJ
cord-000372-wzwpyvll	273	19	and	and	CC
cord-000372-wzwpyvll	273	20	IRES	IRES	NNP
cord-000372-wzwpyvll	273	21	-	-	HYPH
cord-000372-wzwpyvll	273	22	driven	drive	VBN
cord-000372-wzwpyvll	273	23	mRNAs	mRNAs	NNPS
cord-000372-wzwpyvll	273	24	in	in	IN
cord-000372-wzwpyvll	273	25	reticulocyte	reticulocyte	NN
cord-000372-wzwpyvll	273	26	lysate	lysate	NN
cord-000372-wzwpyvll	273	27	assays	assay	NNS
cord-000372-wzwpyvll	273	28	[	[	-LRB-
cord-000372-wzwpyvll	273	29	150	150	CD
cord-000372-wzwpyvll	273	30	]	]	-RRB-
cord-000372-wzwpyvll	273	31	.	.	.
cord-000372-wzwpyvll	274	1	However	however	RB
cord-000372-wzwpyvll	274	2	,	,	,
cord-000372-wzwpyvll	274	3	the	the	DT
cord-000372-wzwpyvll	274	4	different	different	JJ
cord-000372-wzwpyvll	274	5	effect	effect	NN
cord-000372-wzwpyvll	274	6	observed	observe	VBN
cord-000372-wzwpyvll	274	7	by	by	IN
cord-000372-wzwpyvll	274	8	these	these	DT
cord-000372-wzwpyvll	274	9	authors	author	NNS
cord-000372-wzwpyvll	274	10	on	on	IN
cord-000372-wzwpyvll	274	11	IRES	IRES	NNP
cord-000372-wzwpyvll	274	12	-	-	HYPH
cord-000372-wzwpyvll	274	13	driven	drive	VBN
cord-000372-wzwpyvll	274	14	translation	translation	NN
cord-000372-wzwpyvll	274	15	can	can	MD
cord-000372-wzwpyvll	274	16	be	be	VB
cord-000372-wzwpyvll	274	17	due	due	JJ
cord-000372-wzwpyvll	274	18	to	to	IN
cord-000372-wzwpyvll	274	19	differences	difference	NNS
cord-000372-wzwpyvll	274	20	already	already	RB
cord-000372-wzwpyvll	274	21	reported	report	VBN
cord-000372-wzwpyvll	274	22	between	between	IN
cord-000372-wzwpyvll	274	23	HeLa	HeLa	NNP
cord-000372-wzwpyvll	274	24	extract	extract	NN
cord-000372-wzwpyvll	274	25	and	and	CC
cord-000372-wzwpyvll	274	26	RRL	RRL	NNP
cord-000372-wzwpyvll	274	27	[	[	-LRB-
cord-000372-wzwpyvll	274	28	143	143	CD
cord-000372-wzwpyvll	274	29	,	,	,
cord-000372-wzwpyvll	274	30	153	153	CD
cord-000372-wzwpyvll	274	31	]	]	-RRB-
cord-000372-wzwpyvll	274	32	.	.	.
cord-000372-wzwpyvll	275	1	In	in	IN
cord-000372-wzwpyvll	275	2	addition	addition	NN
cord-000372-wzwpyvll	275	3	,	,	,
cord-000372-wzwpyvll	275	4	eIF4	eif4	IN
cord-000372-wzwpyvll	275	5	G	g	NN
cord-000372-wzwpyvll	275	6	cleavage	cleavage	NN
cord-000372-wzwpyvll	275	7	is	be	VBZ
cord-000372-wzwpyvll	275	8	executed	execute	VBN
cord-000372-wzwpyvll	275	9	by	by	IN
cord-000372-wzwpyvll	275	10	proteases	protease	NNS
cord-000372-wzwpyvll	275	11	from	from	IN
cord-000372-wzwpyvll	275	12	other	other	JJ
cord-000372-wzwpyvll	275	13	retrovirus	retrovirus	NN
cord-000372-wzwpyvll	275	14	species	specie	NNS
cord-000372-wzwpyvll	275	15	,	,	,
cord-000372-wzwpyvll	275	16	such	such	JJ
cord-000372-wzwpyvll	275	17	as	as	IN
cord-000372-wzwpyvll	275	18	HIV-2	HIV-2	NNP
cord-000372-wzwpyvll	275	19	,	,	,
cord-000372-wzwpyvll	275	20	simian	simian	JJ
cord-000372-wzwpyvll	275	21	immunodeficiency	immunodeficiency	NN
cord-000372-wzwpyvll	275	22	virus	virus	NN
cord-000372-wzwpyvll	275	23	(	(	-LRB-
cord-000372-wzwpyvll	275	24	SIV	SIV	NNP
cord-000372-wzwpyvll	275	25	)	)	-RRB-
cord-000372-wzwpyvll	275	26	,	,	,
cord-000372-wzwpyvll	275	27	human	human	JJ
cord-000372-wzwpyvll	275	28	T	t	NN
cord-000372-wzwpyvll	275	29	-	-	HYPH
cord-000372-wzwpyvll	275	30	cell	cell	NN
cord-000372-wzwpyvll	275	31	leukemia	leukemia	NN
cord-000372-wzwpyvll	275	32	virus	virus	NN
cord-000372-wzwpyvll	275	33	(	(	-LRB-
cord-000372-wzwpyvll	275	34	HTLV-1	HTLV-1	NNP
cord-000372-wzwpyvll	275	35	)	)	-RRB-
cord-000372-wzwpyvll	275	36	,	,	,
cord-000372-wzwpyvll	275	37	Moloney	Moloney	NNP
cord-000372-wzwpyvll	275	38	murine	murine	JJ
cord-000372-wzwpyvll	275	39	leukemia	leukemia	NN
cord-000372-wzwpyvll	275	40	virus	virus	NN
cord-000372-wzwpyvll	275	41	(	(	-LRB-
cord-000372-wzwpyvll	275	42	MoMLV	MoMLV	NNP
cord-000372-wzwpyvll	275	43	)	)	-RRB-
cord-000372-wzwpyvll	275	44	,	,	,
cord-000372-wzwpyvll	275	45	and	and	CC
cord-000372-wzwpyvll	275	46	mouse	mouse	NN
cord-000372-wzwpyvll	275	47	mammary	mammary	JJ
cord-000372-wzwpyvll	275	48	tumor	tumor	NN
cord-000372-wzwpyvll	275	49	virus	virus	NN
cord-000372-wzwpyvll	275	50	(	(	-LRB-
cord-000372-wzwpyvll	275	51	MMTV	MMTV	NNP
cord-000372-wzwpyvll	275	52	)	)	-RRB-
cord-000372-wzwpyvll	275	53	.	.	.
cord-000372-wzwpyvll	276	1	These	these	DT
cord-000372-wzwpyvll	276	2	proteases	protease	NNS
cord-000372-wzwpyvll	276	3	hydrolyze	hydrolyze	VBP
cord-000372-wzwpyvll	276	4	eIF4GI	eIF4GI	NNS
cord-000372-wzwpyvll	276	5	and	and	CC
cord-000372-wzwpyvll	276	6	eIF4GII	eIF4GII	VBZ
cord-000372-wzwpyvll	276	7	with	with	IN
cord-000372-wzwpyvll	276	8	different	different	JJ
cord-000372-wzwpyvll	276	9	cleavage	cleavage	NN
cord-000372-wzwpyvll	276	10	patterns	pattern	NNS
cord-000372-wzwpyvll	276	11	and	and	CC
cord-000372-wzwpyvll	276	12	kinetics	kinetic	NNS
cord-000372-wzwpyvll	276	13	[	[	-LRB-
cord-000372-wzwpyvll	276	14	134	134	CD
cord-000372-wzwpyvll	276	15	]	]	-RRB-
cord-000372-wzwpyvll	276	16	.	.	.
cord-000372-wzwpyvll	277	1	And	and	CC
cord-000372-wzwpyvll	277	2	indeed	indeed	RB
cord-000372-wzwpyvll	277	3	,	,	,
cord-000372-wzwpyvll	277	4	several	several	JJ
cord-000372-wzwpyvll	277	5	retroviruses	retrovirus	NNS
cord-000372-wzwpyvll	277	6	,	,	,
cord-000372-wzwpyvll	277	7	including	include	VBG
cord-000372-wzwpyvll	277	8	HIV	HIV	NNP
cord-000372-wzwpyvll	277	9	,	,	,
cord-000372-wzwpyvll	277	10	SIV	SIV	NNP
cord-000372-wzwpyvll	277	11	,	,	,
cord-000372-wzwpyvll	277	12	and	and	CC
cord-000372-wzwpyvll	277	13	MoMLV	MoMLV	NNP
cord-000372-wzwpyvll	277	14	,	,	,
cord-000372-wzwpyvll	277	15	promote	promote	VB
cord-000372-wzwpyvll	277	16	the	the	DT
cord-000372-wzwpyvll	277	17	translation	translation	NN
cord-000372-wzwpyvll	277	18	of	of	IN
cord-000372-wzwpyvll	277	19	their	-PRON-	PRP$
cord-000372-wzwpyvll	277	20	gag	gag	NN
cord-000372-wzwpyvll	277	21	gene	gene	NN
cord-000372-wzwpyvll	277	22	products	product	NNS
cord-000372-wzwpyvll	277	23	by	by	IN
cord-000372-wzwpyvll	277	24	internal	internal	JJ
cord-000372-wzwpyvll	277	25	ribosome	ribosome	NN
cord-000372-wzwpyvll	277	26	entry	entry	NN
cord-000372-wzwpyvll	277	27	,	,	,
cord-000372-wzwpyvll	277	28	indicating	indicate	VBG
cord-000372-wzwpyvll	277	29	that	that	IN
cord-000372-wzwpyvll	277	30	eIF4	eIF4	NNP
cord-000372-wzwpyvll	277	31	G	g	NN
cord-000372-wzwpyvll	277	32	cleavage	cleavage	NN
cord-000372-wzwpyvll	277	33	could	could	MD
cord-000372-wzwpyvll	277	34	be	be	VB
cord-000372-wzwpyvll	277	35	compatible	compatible	JJ
cord-000372-wzwpyvll	277	36	with	with	IN
cord-000372-wzwpyvll	277	37	viral	viral	JJ
cord-000372-wzwpyvll	277	38	protein	protein	NN
cord-000372-wzwpyvll	277	39	synthesis	synthesis	NN
cord-000372-wzwpyvll	277	40	in	in	IN
cord-000372-wzwpyvll	277	41	infected	infected	JJ
cord-000372-wzwpyvll	277	42	cells	cell	NNS
cord-000372-wzwpyvll	277	43	[	[	-LRB-
cord-000372-wzwpyvll	277	44	154	154	CD
cord-000372-wzwpyvll	277	45	]	]	-RRB-
cord-000372-wzwpyvll	277	46	[	[	-LRB-
cord-000372-wzwpyvll	277	47	155	155	CD
cord-000372-wzwpyvll	277	48	]	]	-RRB-
cord-000372-wzwpyvll	277	49	[	[	-LRB-
cord-000372-wzwpyvll	277	50	156	156	CD
cord-000372-wzwpyvll	277	51	]	]	-RRB-
cord-000372-wzwpyvll	277	52	.	.	.
cord-000372-wzwpyvll	278	1	Furthermore	furthermore	RB
cord-000372-wzwpyvll	278	2	,	,	,
cord-000372-wzwpyvll	278	3	cleavage	cleavage	NN
cord-000372-wzwpyvll	278	4	of	of	IN
cord-000372-wzwpyvll	278	5	eIF4GI	eif4gi	NN
cord-000372-wzwpyvll	278	6	and	and	CC
cord-000372-wzwpyvll	278	7	eIF4GII	eIF4GII	NNS
cord-000372-wzwpyvll	278	8	also	also	RB
cord-000372-wzwpyvll	278	9	occurs	occur	VBZ
cord-000372-wzwpyvll	278	10	in	in	IN
cord-000372-wzwpyvll	278	11	feline	feline	JJ
cord-000372-wzwpyvll	278	12	calicivirusinfected	calicivirusinfecte	VBN
cord-000372-wzwpyvll	278	13	cells	cell	NNS
cord-000372-wzwpyvll	278	14	although	although	IN
cord-000372-wzwpyvll	278	15	the	the	DT
cord-000372-wzwpyvll	278	16	cleavages	cleavage	NNS
cord-000372-wzwpyvll	278	17	occur	occur	VBP
cord-000372-wzwpyvll	278	18	at	at	IN
cord-000372-wzwpyvll	278	19	different	different	JJ
cord-000372-wzwpyvll	278	20	sites	site	NNS
cord-000372-wzwpyvll	278	21	to	to	IN
cord-000372-wzwpyvll	278	22	those	those	DT
cord-000372-wzwpyvll	278	23	observed	observe	VBN
cord-000372-wzwpyvll	278	24	for	for	IN
cord-000372-wzwpyvll	278	25	picornavirus	picornavirus	NNP
cord-000372-wzwpyvll	278	26	proteases	protease	NNS
cord-000372-wzwpyvll	278	27	[	[	-LRB-
cord-000372-wzwpyvll	278	28	157	157	CD
cord-000372-wzwpyvll	278	29	]	]	-RRB-
cord-000372-wzwpyvll	278	30	.	.	.
cord-000372-wzwpyvll	279	1	In	in	IN
cord-000372-wzwpyvll	279	2	addition	addition	NN
cord-000372-wzwpyvll	279	3	,	,	,
cord-000372-wzwpyvll	279	4	the	the	DT
cord-000372-wzwpyvll	279	5	3C	3c	NN
cord-000372-wzwpyvll	279	6	-	-	HYPH
cord-000372-wzwpyvll	279	7	like	like	JJ
cord-000372-wzwpyvll	279	8	protease	protease	NN
cord-000372-wzwpyvll	279	9	of	of	IN
cord-000372-wzwpyvll	279	10	two	two	CD
cord-000372-wzwpyvll	279	11	caliciviruses	caliciviruse	NNS
cord-000372-wzwpyvll	279	12	,	,	,
cord-000372-wzwpyvll	279	13	like	like	IN
cord-000372-wzwpyvll	279	14	PV	PV	NNP
cord-000372-wzwpyvll	279	15	3C	3c	NN
cord-000372-wzwpyvll	279	16	pro	pro	NNP
cord-000372-wzwpyvll	279	17	,	,	,
cord-000372-wzwpyvll	279	18	cleaves	cleave	VBZ
cord-000372-wzwpyvll	279	19	PABP	PABP	NNP
cord-000372-wzwpyvll	279	20	perhaps	perhaps	RB
cord-000372-wzwpyvll	279	21	as	as	IN
cord-000372-wzwpyvll	279	22	a	a	DT
cord-000372-wzwpyvll	279	23	complementary	complementary	JJ
cord-000372-wzwpyvll	279	24	strategy	strategy	NN
cord-000372-wzwpyvll	279	25	to	to	TO
cord-000372-wzwpyvll	279	26	inhibit	inhibit	VB
cord-000372-wzwpyvll	279	27	cellular	cellular	JJ
cord-000372-wzwpyvll	279	28	translation	translation	NN
cord-000372-wzwpyvll	279	29	[	[	-LRB-
cord-000372-wzwpyvll	279	30	158	158	CD
cord-000372-wzwpyvll	279	31	]	]	-RRB-
cord-000372-wzwpyvll	279	32	.	.	.
cord-000372-wzwpyvll	280	1	The	the	DT
cord-000372-wzwpyvll	280	2	fact	fact	NN
cord-000372-wzwpyvll	280	3	that	that	IN
cord-000372-wzwpyvll	280	4	proteases	protease	NNS
cord-000372-wzwpyvll	280	5	from	from	IN
cord-000372-wzwpyvll	280	6	many	many	JJ
cord-000372-wzwpyvll	280	7	picornaviruses	picornavirus	NNS
cord-000372-wzwpyvll	280	8	,	,	,
cord-000372-wzwpyvll	280	9	retroviruses	retrovirus	NNS
cord-000372-wzwpyvll	280	10	and	and	CC
cord-000372-wzwpyvll	280	11	caliciviruses	caliciviruse	NNS
cord-000372-wzwpyvll	280	12	,	,	,
cord-000372-wzwpyvll	280	13	target	target	NN
cord-000372-wzwpyvll	280	14	eIF4	eif4	IN
cord-000372-wzwpyvll	280	15	G	g	NN
cord-000372-wzwpyvll	280	16	,	,	,
cord-000372-wzwpyvll	280	17	and	and	CC
cord-000372-wzwpyvll	280	18	,	,	,
cord-000372-wzwpyvll	280	19	in	in	IN
cord-000372-wzwpyvll	280	20	some	some	DT
cord-000372-wzwpyvll	280	21	cases	case	NNS
cord-000372-wzwpyvll	280	22	,	,	,
cord-000372-wzwpyvll	280	23	PABP	PABP	NNP
cord-000372-wzwpyvll	280	24	,	,	,
cord-000372-wzwpyvll	280	25	strongly	strongly	RB
cord-000372-wzwpyvll	280	26	suggest	suggest	VBP
cord-000372-wzwpyvll	280	27	that	that	IN
cord-000372-wzwpyvll	280	28	those	those	DT
cord-000372-wzwpyvll	280	29	viruses	virus	NNS
cord-000372-wzwpyvll	280	30	may	may	MD
cord-000372-wzwpyvll	280	31	share	share	VB
cord-000372-wzwpyvll	280	32	a	a	DT
cord-000372-wzwpyvll	280	33	common	common	JJ
cord-000372-wzwpyvll	280	34	mechanism	mechanism	NN
cord-000372-wzwpyvll	280	35	to	to	TO
cord-000372-wzwpyvll	280	36	regulate	regulate	VB
cord-000372-wzwpyvll	280	37	cellular	cellular	JJ
cord-000372-wzwpyvll	280	38	and	and	CC
cord-000372-wzwpyvll	280	39	viral	viral	JJ
cord-000372-wzwpyvll	280	40	translation	translation	NN
cord-000372-wzwpyvll	280	41	.	.	.
cord-000372-wzwpyvll	281	1	However	however	RB
cord-000372-wzwpyvll	281	2	,	,	,
cord-000372-wzwpyvll	281	3	further	further	JJ
cord-000372-wzwpyvll	281	4	investigation	investigation	NN
cord-000372-wzwpyvll	281	5	is	be	VBZ
cord-000372-wzwpyvll	281	6	required	require	VBN
cord-000372-wzwpyvll	281	7	to	to	TO
cord-000372-wzwpyvll	281	8	determine	determine	VB
cord-000372-wzwpyvll	281	9	the	the	DT
cord-000372-wzwpyvll	281	10	specific	specific	JJ
cord-000372-wzwpyvll	281	11	contribution	contribution	NN
cord-000372-wzwpyvll	281	12	of	of	IN
cord-000372-wzwpyvll	281	13	eIF4GI	eIF4GI	NNS
cord-000372-wzwpyvll	281	14	,	,	,
cord-000372-wzwpyvll	281	15	eIF4GII	eif4gii	FW
cord-000372-wzwpyvll	281	16	and	and	CC
cord-000372-wzwpyvll	281	17	PABP	PABP	NNP
cord-000372-wzwpyvll	281	18	to	to	IN
cord-000372-wzwpyvll	281	19	the	the	DT
cord-000372-wzwpyvll	281	20	shutoff	shutoff	NN
cord-000372-wzwpyvll	281	21	of	of	IN
cord-000372-wzwpyvll	281	22	host	host	NN
cord-000372-wzwpyvll	281	23	-	-	HYPH
cord-000372-wzwpyvll	281	24	cell	cell	NN
cord-000372-wzwpyvll	281	25	translation	translation	NN
cord-000372-wzwpyvll	281	26	and	and	CC
cord-000372-wzwpyvll	281	27	virus	virus	NN
cord-000372-wzwpyvll	281	28	protein	protein	NN
cord-000372-wzwpyvll	281	29	synthesis	synthesis	NN
cord-000372-wzwpyvll	281	30	.	.	.
cord-000372-wzwpyvll	282	1	The	the	DT
cord-000372-wzwpyvll	282	2	biological	biological	JJ
cord-000372-wzwpyvll	282	3	cycle	cycle	NN
cord-000372-wzwpyvll	282	4	of	of	IN
cord-000372-wzwpyvll	282	5	picornaviruses	picornavirus	NNS
cord-000372-wzwpyvll	282	6	is	be	VBZ
cord-000372-wzwpyvll	282	7	confined	confine	VBN
cord-000372-wzwpyvll	282	8	to	to	IN
cord-000372-wzwpyvll	282	9	the	the	DT
cord-000372-wzwpyvll	282	10	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	282	11	of	of	IN
cord-000372-wzwpyvll	282	12	infected	infected	JJ
cord-000372-wzwpyvll	282	13	cells	cell	NNS
cord-000372-wzwpyvll	282	14	.	.	.
cord-000372-wzwpyvll	283	1	However	however	RB
cord-000372-wzwpyvll	283	2	,	,	,
cord-000372-wzwpyvll	283	3	some	some	DT
cord-000372-wzwpyvll	283	4	of	of	IN
cord-000372-wzwpyvll	283	5	the	the	DT
cord-000372-wzwpyvll	283	6	PV	pv	NN
cord-000372-wzwpyvll	283	7	proteins	protein	NNS
cord-000372-wzwpyvll	283	8	are	be	VBP
cord-000372-wzwpyvll	283	9	able	able	JJ
cord-000372-wzwpyvll	283	10	to	to	TO
cord-000372-wzwpyvll	283	11	target	target	VB
cord-000372-wzwpyvll	283	12	nuclear	nuclear	JJ
cord-000372-wzwpyvll	283	13	proteins	protein	NNS
cord-000372-wzwpyvll	283	14	such	such	JJ
cord-000372-wzwpyvll	283	15	as	as	IN
cord-000372-wzwpyvll	283	16	transcription	transcription	NN
cord-000372-wzwpyvll	283	17	and	and	CC
cord-000372-wzwpyvll	283	18	splicing	splicing	NN
cord-000372-wzwpyvll	283	19	factors	factor	NNS
cord-000372-wzwpyvll	283	20	and	and	CC
cord-000372-wzwpyvll	283	21	proteins	protein	NNS
cord-000372-wzwpyvll	283	22	involved	involve	VBN
cord-000372-wzwpyvll	283	23	in	in	IN
cord-000372-wzwpyvll	283	24	nuclear	nuclear	JJ
cord-000372-wzwpyvll	283	25	-	-	HYPH
cord-000372-wzwpyvll	283	26	cytoplasmic	cytoplasmic	JJ
cord-000372-wzwpyvll	283	27	trafficking	trafficking	NN
cord-000372-wzwpyvll	283	28	.	.	.
cord-000372-wzwpyvll	284	1	One	one	CD
cord-000372-wzwpyvll	284	2	of	of	IN
cord-000372-wzwpyvll	284	3	the	the	DT
cord-000372-wzwpyvll	284	4	best	well	RBS
cord-000372-wzwpyvll	284	5	studied	study	VBN
cord-000372-wzwpyvll	284	6	cases	case	NNS
cord-000372-wzwpyvll	284	7	in	in	IN
cord-000372-wzwpyvll	284	8	this	this	DT
cord-000372-wzwpyvll	284	9	regard	regard	NN
cord-000372-wzwpyvll	284	10	is	be	VBZ
cord-000372-wzwpyvll	284	11	the	the	DT
cord-000372-wzwpyvll	284	12	cleavage	cleavage	NN
cord-000372-wzwpyvll	284	13	of	of	IN
cord-000372-wzwpyvll	284	14	nucleoporins	nucleoporin	NNS
cord-000372-wzwpyvll	284	15	(	(	-LRB-
cord-000372-wzwpyvll	284	16	Nups	Nups	NNP
cord-000372-wzwpyvll	284	17	)	)	-RRB-
cord-000372-wzwpyvll	284	18	,	,	,
cord-000372-wzwpyvll	284	19	components	component	NNS
cord-000372-wzwpyvll	284	20	of	of	IN
cord-000372-wzwpyvll	284	21	the	the	DT
cord-000372-wzwpyvll	284	22	nuclear	nuclear	JJ
cord-000372-wzwpyvll	284	23	pore	pore	NN
cord-000372-wzwpyvll	284	24	complex	complex	NN
cord-000372-wzwpyvll	284	25	(	(	-LRB-
cord-000372-wzwpyvll	284	26	NPC	NPC	NNP
cord-000372-wzwpyvll	284	27	)	)	-RRB-
cord-000372-wzwpyvll	284	28	,	,	,
cord-000372-wzwpyvll	284	29	by	by	IN
cord-000372-wzwpyvll	284	30	PV	PV	NNP
cord-000372-wzwpyvll	284	31	and	and	CC
cord-000372-wzwpyvll	284	32	HRV	HRV	NNP
cord-000372-wzwpyvll	284	33	2A	2A	NNP
cord-000372-wzwpyvll	284	34	pro	pro	NNP
cord-000372-wzwpyvll	284	35	,	,	,
cord-000372-wzwpyvll	284	36	which	which	WDT
cord-000372-wzwpyvll	284	37	directly	directly	RB
cord-000372-wzwpyvll	284	38	impacts	impact	VBZ
cord-000372-wzwpyvll	284	39	on	on	IN
cord-000372-wzwpyvll	284	40	nuclear	nuclear	JJ
cord-000372-wzwpyvll	284	41	-	-	HYPH
cord-000372-wzwpyvll	284	42	cytoplasmic	cytoplasmic	JJ
cord-000372-wzwpyvll	284	43	trafficking	trafficking	NN
cord-000372-wzwpyvll	284	44	of	of	IN
cord-000372-wzwpyvll	284	45	proteins	protein	NNS
cord-000372-wzwpyvll	284	46	and	and	CC
cord-000372-wzwpyvll	284	47	RNAs	rna	NNS
cord-000372-wzwpyvll	284	48	[	[	-LRB-
cord-000372-wzwpyvll	284	49	15	15	CD
cord-000372-wzwpyvll	284	50	,	,	,
cord-000372-wzwpyvll	284	51	16	16	CD
cord-000372-wzwpyvll	284	52	,	,	,
cord-000372-wzwpyvll	284	53	159	159	CD
cord-000372-wzwpyvll	284	54	]	]	-RRB-
cord-000372-wzwpyvll	284	55	.	.	.
cord-000372-wzwpyvll	285	1	Complementarily	Complementarily	NNP
cord-000372-wzwpyvll	285	2	,	,	,
cord-000372-wzwpyvll	285	3	EMCV	EMCV	NNP
cord-000372-wzwpyvll	285	4	L	L	NNP
cord-000372-wzwpyvll	285	5	protein	protein	NN
cord-000372-wzwpyvll	285	6	affects	affect	VBZ
cord-000372-wzwpyvll	285	7	on	on	IN
cord-000372-wzwpyvll	285	8	the	the	DT
cord-000372-wzwpyvll	285	9	phosphorylation	phosphorylation	NN
cord-000372-wzwpyvll	285	10	status	status	NN
cord-000372-wzwpyvll	285	11	of	of	IN
cord-000372-wzwpyvll	285	12	Nup62	Nup62	NNP
cord-000372-wzwpyvll	285	13	and	and	CC
cord-000372-wzwpyvll	285	14	induces	induce	VBZ
cord-000372-wzwpyvll	285	15	similar	similar	JJ
cord-000372-wzwpyvll	285	16	effects	effect	NNS
cord-000372-wzwpyvll	285	17	to	to	IN
cord-000372-wzwpyvll	285	18	those	those	DT
cord-000372-wzwpyvll	285	19	described	describe	VBN
cord-000372-wzwpyvll	285	20	for	for	IN
cord-000372-wzwpyvll	285	21	PV	PV	NNP
cord-000372-wzwpyvll	285	22	2A	2a	CD
cord-000372-wzwpyvll	285	23	pro	pro	JJ
cord-000372-wzwpyvll	285	24	in	in	IN
cord-000372-wzwpyvll	285	25	the	the	DT
cord-000372-wzwpyvll	285	26	transport	transport	NN
cord-000372-wzwpyvll	285	27	of	of	IN
cord-000372-wzwpyvll	285	28	macromolecules	macromolecule	NNS
cord-000372-wzwpyvll	285	29	through	through	IN
cord-000372-wzwpyvll	285	30	NPC	NPC	NNP
cord-000372-wzwpyvll	285	31	[	[	-LRB-
cord-000372-wzwpyvll	285	32	160	160	CD
cord-000372-wzwpyvll	285	33	]	]	-RRB-
cord-000372-wzwpyvll	285	34	.	.	.
cord-000372-wzwpyvll	286	1	Nevertheless	nevertheless	RB
cord-000372-wzwpyvll	286	2	,	,	,
cord-000372-wzwpyvll	286	3	Nups	Nups	NNP
cord-000372-wzwpyvll	286	4	are	be	VBP
cord-000372-wzwpyvll	286	5	not	not	RB
cord-000372-wzwpyvll	286	6	only	only	RB
cord-000372-wzwpyvll	286	7	targets	target	NNS
cord-000372-wzwpyvll	286	8	for	for	IN
cord-000372-wzwpyvll	286	9	picornavirus	picornavirus	NN
cord-000372-wzwpyvll	286	10	proteins	protein	NNS
cord-000372-wzwpyvll	286	11	but	but	CC
cord-000372-wzwpyvll	286	12	also	also	RB
cord-000372-wzwpyvll	286	13	for	for	IN
cord-000372-wzwpyvll	286	14	matrix	matrix	NN
cord-000372-wzwpyvll	286	15	(	(	-LRB-
cord-000372-wzwpyvll	286	16	M	M	NNP
cord-000372-wzwpyvll	286	17	)	)	-RRB-
cord-000372-wzwpyvll	286	18	protein	protein	NN
cord-000372-wzwpyvll	286	19	from	from	IN
cord-000372-wzwpyvll	286	20	Vesicular	Vesicular	NNP
cord-000372-wzwpyvll	286	21	stomatitis	stomatitis	NN
cord-000372-wzwpyvll	286	22	virus	virus	NN
cord-000372-wzwpyvll	286	23	(	(	-LRB-
cord-000372-wzwpyvll	286	24	VSV	VSV	NNP
cord-000372-wzwpyvll	286	25	)	)	-RRB-
cord-000372-wzwpyvll	286	26	[	[	-LRB-
cord-000372-wzwpyvll	286	27	161	161	CD
cord-000372-wzwpyvll	286	28	]	]	-RRB-
cord-000372-wzwpyvll	286	29	and	and	CC
cord-000372-wzwpyvll	286	30	nonstructural	nonstructural	JJ
cord-000372-wzwpyvll	286	31	protein	protein	NN
cord-000372-wzwpyvll	286	32	1	1	CD
cord-000372-wzwpyvll	286	33	(	(	-LRB-
cord-000372-wzwpyvll	286	34	NS1	ns1	NN
cord-000372-wzwpyvll	286	35	)	)	-RRB-
cord-000372-wzwpyvll	286	36	from	from	IN
cord-000372-wzwpyvll	286	37	influenza	influenza	NN
cord-000372-wzwpyvll	286	38	virus	virus	NN
cord-000372-wzwpyvll	286	39	[	[	-LRB-
cord-000372-wzwpyvll	286	40	162	162	CD
cord-000372-wzwpyvll	286	41	]	]	-RRB-
cord-000372-wzwpyvll	286	42	,	,	,
cord-000372-wzwpyvll	286	43	which	which	WDT
cord-000372-wzwpyvll	286	44	also	also	RB
cord-000372-wzwpyvll	286	45	impair	impair	VBP
cord-000372-wzwpyvll	286	46	components	component	NNS
cord-000372-wzwpyvll	286	47	of	of	IN
cord-000372-wzwpyvll	286	48	the	the	DT
cord-000372-wzwpyvll	286	49	nuclear	nuclear	JJ
cord-000372-wzwpyvll	286	50	export	export	NN
cord-000372-wzwpyvll	286	51	-	-	HYPH
cord-000372-wzwpyvll	286	52	import	import	NN
cord-000372-wzwpyvll	286	53	host	host	NN
cord-000372-wzwpyvll	286	54	machinery	machinery	NN
cord-000372-wzwpyvll	286	55	following	follow	VBG
cord-000372-wzwpyvll	286	56	analogous	analogous	JJ
cord-000372-wzwpyvll	286	57	mechanisms	mechanism	NNS
cord-000372-wzwpyvll	286	58	.	.	.
cord-000372-wzwpyvll	287	1	Taking	take	VBG
cord-000372-wzwpyvll	287	2	into	into	IN
cord-000372-wzwpyvll	287	3	account	account	NN
cord-000372-wzwpyvll	287	4	that	that	WDT
cord-000372-wzwpyvll	287	5	proteins	protein	NNS
cord-000372-wzwpyvll	287	6	from	from	IN
cord-000372-wzwpyvll	287	7	different	different	JJ
cord-000372-wzwpyvll	287	8	positive	positive	JJ
cord-000372-wzwpyvll	287	9	and	and	CC
cord-000372-wzwpyvll	287	10	negative	negative	JJ
cord-000372-wzwpyvll	287	11	strand	strand	NN
cord-000372-wzwpyvll	288	1	RNA	RNA	NNP
cord-000372-wzwpyvll	288	2	viruses	virus	NNS
cord-000372-wzwpyvll	288	3	target	target	VBP
cord-000372-wzwpyvll	288	4	Nups	Nups	NNP
cord-000372-wzwpyvll	288	5	,	,	,
cord-000372-wzwpyvll	288	6	we	-PRON-	PRP
cord-000372-wzwpyvll	288	7	highlight	highlight	VBP
cord-000372-wzwpyvll	288	8	in	in	IN
cord-000372-wzwpyvll	288	9	this	this	DT
cord-000372-wzwpyvll	288	10	paper	paper	NN
cord-000372-wzwpyvll	288	11	NPC	NPC	NNP
cord-000372-wzwpyvll	288	12	as	as	IN
cord-000372-wzwpyvll	288	13	a	a	DT
cord-000372-wzwpyvll	288	14	key	key	JJ
cord-000372-wzwpyvll	288	15	target	target	NN
cord-000372-wzwpyvll	288	16	for	for	IN
cord-000372-wzwpyvll	288	17	viral	viral	JJ
cord-000372-wzwpyvll	288	18	proteins	protein	NNS
cord-000372-wzwpyvll	288	19	,	,	,
cord-000372-wzwpyvll	288	20	although	although	IN
cord-000372-wzwpyvll	288	21	the	the	DT
cord-000372-wzwpyvll	288	22	possible	possible	JJ
cord-000372-wzwpyvll	288	23	role	role	NN
cord-000372-wzwpyvll	288	24	of	of	IN
cord-000372-wzwpyvll	288	25	NPC	NPC	NNP
cord-000372-wzwpyvll	288	26	in	in	IN
cord-000372-wzwpyvll	288	27	virus	virus	NN
cord-000372-wzwpyvll	288	28	biological	biological	JJ
cord-000372-wzwpyvll	288	29	cycle	cycle	NN
cord-000372-wzwpyvll	288	30	is	be	VBZ
cord-000372-wzwpyvll	288	31	still	still	RB
cord-000372-wzwpyvll	288	32	under	under	IN
cord-000372-wzwpyvll	288	33	intensive	intensive	JJ
cord-000372-wzwpyvll	288	34	research	research	NN
cord-000372-wzwpyvll	288	35	.	.	.
cord-000372-wzwpyvll	289	1	Nucleus	nucleus	NN
cord-000372-wzwpyvll	289	2	and	and	CC
cord-000372-wzwpyvll	289	3	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	289	4	are	be	VBP
cord-000372-wzwpyvll	289	5	physically	physically	RB
cord-000372-wzwpyvll	289	6	separated	separate	VBN
cord-000372-wzwpyvll	289	7	by	by	IN
cord-000372-wzwpyvll	289	8	a	a	DT
cord-000372-wzwpyvll	289	9	semipermeable	semipermeable	JJ
cord-000372-wzwpyvll	289	10	barrier	barrier	NN
cord-000372-wzwpyvll	289	11	known	know	VBN
cord-000372-wzwpyvll	289	12	as	as	IN
cord-000372-wzwpyvll	289	13	the	the	DT
cord-000372-wzwpyvll	289	14	nuclear	nuclear	JJ
cord-000372-wzwpyvll	289	15	envelope	envelope	NN
cord-000372-wzwpyvll	289	16	.	.	.
cord-000372-wzwpyvll	290	1	Due	due	IN
cord-000372-wzwpyvll	290	2	to	to	IN
cord-000372-wzwpyvll	290	3	this	this	DT
cord-000372-wzwpyvll	290	4	compartmentalization	compartmentalization	NN
cord-000372-wzwpyvll	290	5	,	,	,
cord-000372-wzwpyvll	290	6	a	a	DT
cord-000372-wzwpyvll	290	7	large	large	JJ
cord-000372-wzwpyvll	290	8	number	number	NN
cord-000372-wzwpyvll	290	9	of	of	IN
cord-000372-wzwpyvll	290	10	macromolecules	macromolecule	NNS
cord-000372-wzwpyvll	290	11	traverse	traverse	VBP
cord-000372-wzwpyvll	290	12	the	the	DT
cord-000372-wzwpyvll	290	13	nuclear	nuclear	JJ
cord-000372-wzwpyvll	290	14	envelope	envelope	NN
cord-000372-wzwpyvll	290	15	to	to	TO
cord-000372-wzwpyvll	290	16	reach	reach	VB
cord-000372-wzwpyvll	290	17	their	-PRON-	PRP$
cord-000372-wzwpyvll	290	18	biological	biological	JJ
cord-000372-wzwpyvll	290	19	destination	destination	NN
cord-000372-wzwpyvll	290	20	.	.	.
cord-000372-wzwpyvll	291	1	For	for	IN
cord-000372-wzwpyvll	291	2	example	example	NN
cord-000372-wzwpyvll	291	3	,	,	,
cord-000372-wzwpyvll	291	4	proteins	protein	NNS
cord-000372-wzwpyvll	291	5	are	be	VBP
cord-000372-wzwpyvll	291	6	synthesized	synthesize	VBN
cord-000372-wzwpyvll	291	7	by	by	IN
cord-000372-wzwpyvll	291	8	ribosomes	ribosome	NNS
cord-000372-wzwpyvll	291	9	in	in	IN
cord-000372-wzwpyvll	291	10	the	the	DT
cord-000372-wzwpyvll	291	11	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	291	12	,	,	,
cord-000372-wzwpyvll	291	13	but	but	CC
cord-000372-wzwpyvll	291	14	some	some	DT
cord-000372-wzwpyvll	291	15	of	of	IN
cord-000372-wzwpyvll	291	16	them	-PRON-	PRP
cord-000372-wzwpyvll	291	17	such	such	JJ
cord-000372-wzwpyvll	291	18	as	as	IN
cord-000372-wzwpyvll	291	19	polymerases	polymerase	NNS
cord-000372-wzwpyvll	291	20	,	,	,
cord-000372-wzwpyvll	291	21	transcription	transcription	NN
cord-000372-wzwpyvll	291	22	factors	factor	NNS
cord-000372-wzwpyvll	291	23	,	,	,
cord-000372-wzwpyvll	291	24	nucleosome	nucleosome	NN
cord-000372-wzwpyvll	291	25	components	component	NNS
cord-000372-wzwpyvll	291	26	and	and	CC
cord-000372-wzwpyvll	291	27	splicing	splicing	NN
cord-000372-wzwpyvll	291	28	factors	factor	NNS
cord-000372-wzwpyvll	291	29	,	,	,
cord-000372-wzwpyvll	291	30	have	have	VBP
cord-000372-wzwpyvll	291	31	to	to	TO
cord-000372-wzwpyvll	291	32	traverse	traverse	VB
cord-000372-wzwpyvll	291	33	the	the	DT
cord-000372-wzwpyvll	291	34	NPC	NPC	NNP
cord-000372-wzwpyvll	291	35	to	to	TO
cord-000372-wzwpyvll	291	36	reach	reach	VB
cord-000372-wzwpyvll	291	37	the	the	DT
cord-000372-wzwpyvll	291	38	nucleoplasm	nucleoplasm	NN
cord-000372-wzwpyvll	291	39	.	.	.
cord-000372-wzwpyvll	292	1	Conversely	conversely	RB
cord-000372-wzwpyvll	292	2	,	,	,
cord-000372-wzwpyvll	292	3	all	all	DT
cord-000372-wzwpyvll	292	4	RNA	RNA	NNP
cord-000372-wzwpyvll	292	5	species	specie	NNS
cord-000372-wzwpyvll	292	6	are	be	VBP
cord-000372-wzwpyvll	292	7	transcribed	transcribe	VBN
cord-000372-wzwpyvll	292	8	and	and	CC
cord-000372-wzwpyvll	292	9	processed	process	VBN
cord-000372-wzwpyvll	292	10	in	in	IN
cord-000372-wzwpyvll	292	11	the	the	DT
cord-000372-wzwpyvll	292	12	nucleus	nucleus	NN
cord-000372-wzwpyvll	292	13	and	and	CC
cord-000372-wzwpyvll	292	14	later	later	RB
cord-000372-wzwpyvll	292	15	,	,	,
cord-000372-wzwpyvll	292	16	most	most	JJS
cord-000372-wzwpyvll	292	17	of	of	IN
cord-000372-wzwpyvll	292	18	mature	mature	JJ
cord-000372-wzwpyvll	292	19	RNAs	rna	NNS
cord-000372-wzwpyvll	292	20	are	be	VBP
cord-000372-wzwpyvll	292	21	exported	export	VBN
cord-000372-wzwpyvll	292	22	through	through	IN
cord-000372-wzwpyvll	292	23	the	the	DT
cord-000372-wzwpyvll	292	24	NPC	NPC	NNP
cord-000372-wzwpyvll	292	25	to	to	IN
cord-000372-wzwpyvll	292	26	the	the	DT
cord-000372-wzwpyvll	292	27	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	292	28	,	,	,
cord-000372-wzwpyvll	292	29	where	where	WRB
cord-000372-wzwpyvll	292	30	their	-PRON-	PRP$
cord-000372-wzwpyvll	292	31	biological	biological	JJ
cord-000372-wzwpyvll	292	32	roles	role	NNS
cord-000372-wzwpyvll	292	33	take	take	VBP
cord-000372-wzwpyvll	292	34	place	place	NN
cord-000372-wzwpyvll	292	35	.	.	.
cord-000372-wzwpyvll	293	1	Therefore	therefore	RB
cord-000372-wzwpyvll	293	2	,	,	,
cord-000372-wzwpyvll	293	3	the	the	DT
cord-000372-wzwpyvll	293	4	regulation	regulation	NN
cord-000372-wzwpyvll	293	5	of	of	IN
cord-000372-wzwpyvll	293	6	RNA	RNA	NNP
cord-000372-wzwpyvll	293	7	and	and	CC
cord-000372-wzwpyvll	293	8	protein	protein	NN
cord-000372-wzwpyvll	293	9	trafficking	trafficking	NN
cord-000372-wzwpyvll	293	10	between	between	IN
cord-000372-wzwpyvll	293	11	nucleus	nucleus	NN
cord-000372-wzwpyvll	293	12	and	and	CC
cord-000372-wzwpyvll	293	13	cytoplasm	cytoplasm	VB
cord-000372-wzwpyvll	293	14	directly	directly	RB
cord-000372-wzwpyvll	293	15	impacts	impact	NNS
cord-000372-wzwpyvll	293	16	on	on	IN
cord-000372-wzwpyvll	293	17	gene	gene	NN
cord-000372-wzwpyvll	293	18	expression	expression	NN
cord-000372-wzwpyvll	293	19	[	[	-LRB-
cord-000372-wzwpyvll	293	20	163	163	CD
cord-000372-wzwpyvll	293	21	,	,	,
cord-000372-wzwpyvll	293	22	164	164	CD
cord-000372-wzwpyvll	293	23	]	]	-RRB-
cord-000372-wzwpyvll	293	24	.	.	.
cord-000372-wzwpyvll	294	1	NPC	NPC	NNP
cord-000372-wzwpyvll	294	2	forms	form	VBZ
cord-000372-wzwpyvll	294	3	large	large	JJ
cord-000372-wzwpyvll	294	4	structures	structure	NNS
cord-000372-wzwpyvll	294	5	(	(	-LRB-
cord-000372-wzwpyvll	294	6	∼125	∼125	NNP
cord-000372-wzwpyvll	294	7	MDa	MDa	NNP
cord-000372-wzwpyvll	294	8	)	)	-RRB-
cord-000372-wzwpyvll	294	9	embedded	embed	VBN
cord-000372-wzwpyvll	294	10	in	in	IN
cord-000372-wzwpyvll	294	11	the	the	DT
cord-000372-wzwpyvll	294	12	nuclear	nuclear	JJ
cord-000372-wzwpyvll	294	13	envelope	envelope	NN
cord-000372-wzwpyvll	294	14	with	with	IN
cord-000372-wzwpyvll	294	15	a	a	DT
cord-000372-wzwpyvll	294	16	polarized	polarized	JJ
cord-000372-wzwpyvll	294	17	eightfold	eightfold	JJ
cord-000372-wzwpyvll	294	18	symmetrical	symmetrical	JJ
cord-000372-wzwpyvll	294	19	core	core	NN
cord-000372-wzwpyvll	294	20	.	.	.
cord-000372-wzwpyvll	295	1	It	-PRON-	PRP
cord-000372-wzwpyvll	295	2	is	be	VBZ
cord-000372-wzwpyvll	295	3	sandwiched	sandwich	VBN
cord-000372-wzwpyvll	295	4	by	by	IN
cord-000372-wzwpyvll	295	5	a	a	DT
cord-000372-wzwpyvll	295	6	cytoplasmic	cytoplasmic	JJ
cord-000372-wzwpyvll	295	7	and	and	CC
cord-000372-wzwpyvll	295	8	nuclear	nuclear	JJ
cord-000372-wzwpyvll	295	9	ring	ring	NN
cord-000372-wzwpyvll	295	10	,	,	,
cord-000372-wzwpyvll	295	11	which	which	WDT
cord-000372-wzwpyvll	295	12	projects	project	VBZ
cord-000372-wzwpyvll	295	13	eight	eight	CD
cord-000372-wzwpyvll	295	14	filaments	filament	NNS
cord-000372-wzwpyvll	295	15	of	of	IN
cord-000372-wzwpyvll	295	16	about	about	RB
cord-000372-wzwpyvll	295	17	50	50	CD
cord-000372-wzwpyvll	295	18	nm	nm	NN
cord-000372-wzwpyvll	295	19	into	into	IN
cord-000372-wzwpyvll	295	20	the	the	DT
cord-000372-wzwpyvll	295	21	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	295	22	and	and	CC
cord-000372-wzwpyvll	295	23	a	a	DT
cord-000372-wzwpyvll	295	24	basket	basket	NN
cord-000372-wzwpyvll	295	25	-	-	HYPH
cord-000372-wzwpyvll	295	26	like	like	JJ
cord-000372-wzwpyvll	295	27	structure	structure	NN
cord-000372-wzwpyvll	295	28	of	of	IN
cord-000372-wzwpyvll	295	29	about	about	RB
cord-000372-wzwpyvll	295	30	100	100	CD
cord-000372-wzwpyvll	295	31	nm	nm	NN
cord-000372-wzwpyvll	295	32	into	into	IN
cord-000372-wzwpyvll	295	33	the	the	DT
cord-000372-wzwpyvll	295	34	nucleoplasm	nucleoplasm	NN
cord-000372-wzwpyvll	295	35	[	[	-LRB-
cord-000372-wzwpyvll	295	36	165	165	CD
cord-000372-wzwpyvll	295	37	,	,	,
cord-000372-wzwpyvll	295	38	166	166	CD
cord-000372-wzwpyvll	295	39	]	]	-RRB-
cord-000372-wzwpyvll	295	40	.	.	.
cord-000372-wzwpyvll	296	1	The	the	DT
cord-000372-wzwpyvll	296	2	NPC	NPC	NNP
cord-000372-wzwpyvll	296	3	is	be	VBZ
cord-000372-wzwpyvll	296	4	composed	compose	VBN
cord-000372-wzwpyvll	296	5	of	of	IN
cord-000372-wzwpyvll	296	6	multiple	multiple	JJ
cord-000372-wzwpyvll	296	7	copies	copy	NNS
cord-000372-wzwpyvll	296	8	(	(	-LRB-
cord-000372-wzwpyvll	296	9	8	8	CD
cord-000372-wzwpyvll	296	10	,	,	,
cord-000372-wzwpyvll	296	11	16	16	CD
cord-000372-wzwpyvll	296	12	or	or	CC
cord-000372-wzwpyvll	296	13	32	32	CD
cord-000372-wzwpyvll	296	14	)	)	-RRB-
cord-000372-wzwpyvll	296	15	of	of	IN
cord-000372-wzwpyvll	296	16	∼30	∼30	NN
cord-000372-wzwpyvll	296	17	different	different	JJ
cord-000372-wzwpyvll	296	18	proteins	protein	NNS
cord-000372-wzwpyvll	296	19	,	,	,
cord-000372-wzwpyvll	296	20	called	call	VBN
cord-000372-wzwpyvll	296	21	Nups	Nups	NNP
cord-000372-wzwpyvll	296	22	,	,	,
cord-000372-wzwpyvll	296	23	that	that	WDT
cord-000372-wzwpyvll	296	24	are	be	VBP
cord-000372-wzwpyvll	296	25	grouped	group	VBN
cord-000372-wzwpyvll	296	26	in	in	IN
cord-000372-wzwpyvll	296	27	three	three	CD
cord-000372-wzwpyvll	296	28	major	major	JJ
cord-000372-wzwpyvll	296	29	classes	class	NNS
cord-000372-wzwpyvll	296	30	:	:	:
cord-000372-wzwpyvll	296	31	(	(	-LRB-
cord-000372-wzwpyvll	296	32	i	i	NN
cord-000372-wzwpyvll	296	33	)	)	-RRB-
cord-000372-wzwpyvll	297	1	the	the	DT
cord-000372-wzwpyvll	297	2	phenylalanineglycine	phenylalanineglycine	NNP
cord-000372-wzwpyvll	297	3	(	(	-LRB-
cord-000372-wzwpyvll	297	4	FG)-containing	fg)-containe	VBG
cord-000372-wzwpyvll	297	5	nucleoporins	nucleoporin	NNS
cord-000372-wzwpyvll	297	6	that	that	WDT
cord-000372-wzwpyvll	297	7	actively	actively	RB
cord-000372-wzwpyvll	297	8	work	work	VBP
cord-000372-wzwpyvll	297	9	in	in	IN
cord-000372-wzwpyvll	297	10	the	the	DT
cord-000372-wzwpyvll	297	11	nuclear	nuclear	JJ
cord-000372-wzwpyvll	297	12	-	-	HYPH
cord-000372-wzwpyvll	297	13	cytoplasmic	cytoplasmic	JJ
cord-000372-wzwpyvll	297	14	trafficking	trafficking	NN
cord-000372-wzwpyvll	297	15	of	of	IN
cord-000372-wzwpyvll	297	16	macromolecules	macromolecule	NNS
cord-000372-wzwpyvll	297	17	;	;	,
cord-000372-wzwpyvll	297	18	(	(	-LRB-
cord-000372-wzwpyvll	297	19	ii	ii	NN
cord-000372-wzwpyvll	297	20	)	)	-RRB-
cord-000372-wzwpyvll	297	21	the	the	DT
cord-000372-wzwpyvll	297	22	structural	structural	JJ
cord-000372-wzwpyvll	297	23	components	component	NNS
cord-000372-wzwpyvll	297	24	,	,	,
cord-000372-wzwpyvll	297	25	which	which	WDT
cord-000372-wzwpyvll	297	26	lack	lack	VBP
cord-000372-wzwpyvll	297	27	FG	fg	NN
cord-000372-wzwpyvll	297	28	-	-	HYPH
cord-000372-wzwpyvll	297	29	rich	rich	JJ
cord-000372-wzwpyvll	297	30	domains	domain	NNS
cord-000372-wzwpyvll	297	31	and	and	CC
cord-000372-wzwpyvll	297	32	(	(	-LRB-
cord-000372-wzwpyvll	297	33	iii	iii	NN
cord-000372-wzwpyvll	297	34	)	)	-RRB-
cord-000372-wzwpyvll	298	1	the	the	DT
cord-000372-wzwpyvll	298	2	membrane	membrane	NN
cord-000372-wzwpyvll	298	3	integral	integral	JJ
cord-000372-wzwpyvll	298	4	proteins	protein	NNS
cord-000372-wzwpyvll	298	5	,	,	,
cord-000372-wzwpyvll	298	6	which	which	WDT
cord-000372-wzwpyvll	298	7	anchor	anchor	VBD
cord-000372-wzwpyvll	298	8	the	the	DT
cord-000372-wzwpyvll	298	9	NPC	NPC	NNP
cord-000372-wzwpyvll	298	10	to	to	IN
cord-000372-wzwpyvll	298	11	the	the	DT
cord-000372-wzwpyvll	298	12	nuclear	nuclear	JJ
cord-000372-wzwpyvll	298	13	envelope	envelope	NN
cord-000372-wzwpyvll	298	14	[	[	-LRB-
cord-000372-wzwpyvll	298	15	163	163	CD
cord-000372-wzwpyvll	298	16	,	,	,
cord-000372-wzwpyvll	298	17	167	167	CD
cord-000372-wzwpyvll	298	18	]	]	-RRB-
cord-000372-wzwpyvll	298	19	.	.	.
cord-000372-wzwpyvll	299	1	Whereas	whereas	IN
cord-000372-wzwpyvll	299	2	the	the	DT
cord-000372-wzwpyvll	299	3	two	two	CD
cord-000372-wzwpyvll	299	4	last	last	JJ
cord-000372-wzwpyvll	299	5	groups	group	NNS
cord-000372-wzwpyvll	299	6	of	of	IN
cord-000372-wzwpyvll	299	7	nucleoporins	nucleoporin	NNS
cord-000372-wzwpyvll	299	8	play	play	VBP
cord-000372-wzwpyvll	299	9	a	a	DT
cord-000372-wzwpyvll	299	10	role	role	NN
cord-000372-wzwpyvll	299	11	in	in	IN
cord-000372-wzwpyvll	299	12	the	the	DT
cord-000372-wzwpyvll	299	13	architecture	architecture	NN
cord-000372-wzwpyvll	299	14	and	and	CC
cord-000372-wzwpyvll	299	15	localization	localization	NN
cord-000372-wzwpyvll	299	16	of	of	IN
cord-000372-wzwpyvll	299	17	the	the	DT
cord-000372-wzwpyvll	299	18	NPC	NPC	NNP
cord-000372-wzwpyvll	299	19	,	,	,
cord-000372-wzwpyvll	299	20	the	the	DT
cord-000372-wzwpyvll	299	21	FG	FG	NNP
cord-000372-wzwpyvll	299	22	-	-	HYPH
cord-000372-wzwpyvll	299	23	nucleoporins	nucleoporin	NNS
cord-000372-wzwpyvll	299	24	directly	directly	RB
cord-000372-wzwpyvll	299	25	regulate	regulate	VBP
cord-000372-wzwpyvll	299	26	the	the	DT
cord-000372-wzwpyvll	299	27	transport	transport	NN
cord-000372-wzwpyvll	299	28	of	of	IN
cord-000372-wzwpyvll	299	29	RNAs	rna	NNS
cord-000372-wzwpyvll	299	30	and	and	CC
cord-000372-wzwpyvll	299	31	proteins	protein	NNS
cord-000372-wzwpyvll	299	32	through	through	IN
cord-000372-wzwpyvll	299	33	the	the	DT
cord-000372-wzwpyvll	299	34	NPC	NPC	NNP
cord-000372-wzwpyvll	299	35	,	,	,
cord-000372-wzwpyvll	299	36	and	and	CC
cord-000372-wzwpyvll	299	37	they	-PRON-	PRP
cord-000372-wzwpyvll	299	38	are	be	VBP
cord-000372-wzwpyvll	299	39	the	the	DT
cord-000372-wzwpyvll	299	40	main	main	JJ
cord-000372-wzwpyvll	299	41	nucleoporin	nucleoporin	NNP
cord-000372-wzwpyvll	299	42	class	class	NN
cord-000372-wzwpyvll	299	43	targeted	target	VBN
cord-000372-wzwpyvll	299	44	by	by	IN
cord-000372-wzwpyvll	299	45	viruses	virus	NNS
cord-000372-wzwpyvll	299	46	(	(	-LRB-
cord-000372-wzwpyvll	299	47	Figure	figure	NN
cord-000372-wzwpyvll	299	48	4	4	CD
cord-000372-wzwpyvll	299	49	)	)	-RRB-
cord-000372-wzwpyvll	299	50	.	.	.
cord-000372-wzwpyvll	300	1	Movement	movement	NN
cord-000372-wzwpyvll	300	2	of	of	IN
cord-000372-wzwpyvll	300	3	ions	ion	NNS
cord-000372-wzwpyvll	300	4	,	,	,
cord-000372-wzwpyvll	300	5	metabolites	metabolite	NNS
cord-000372-wzwpyvll	300	6	and	and	CC
cord-000372-wzwpyvll	300	7	other	other	JJ
cord-000372-wzwpyvll	300	8	small	small	JJ
cord-000372-wzwpyvll	300	9	molecules	molecule	NNS
cord-000372-wzwpyvll	300	10	between	between	IN
cord-000372-wzwpyvll	300	11	nucleus	nucleus	NN
cord-000372-wzwpyvll	300	12	and	and	CC
cord-000372-wzwpyvll	300	13	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	300	14	takes	take	VBZ
cord-000372-wzwpyvll	300	15	place	place	NN
cord-000372-wzwpyvll	300	16	by	by	IN
cord-000372-wzwpyvll	300	17	passive	passive	JJ
cord-000372-wzwpyvll	300	18	diffusion	diffusion	NN
cord-000372-wzwpyvll	300	19	;	;	:
cord-000372-wzwpyvll	300	20	however	however	RB
cord-000372-wzwpyvll	300	21	,	,	,
cord-000372-wzwpyvll	300	22	transport	transport	NN
cord-000372-wzwpyvll	300	23	cargos	cargo	NNS
cord-000372-wzwpyvll	300	24	larger	large	JJR
cord-000372-wzwpyvll	300	25	than	than	IN
cord-000372-wzwpyvll	300	26	40	40	CD
cord-000372-wzwpyvll	300	27	KDa	KDa	NNS
cord-000372-wzwpyvll	300	28	require	require	VBP
cord-000372-wzwpyvll	300	29	the	the	DT
cord-000372-wzwpyvll	300	30	participation	participation	NN
cord-000372-wzwpyvll	300	31	of	of	IN
cord-000372-wzwpyvll	300	32	specific	specific	JJ
cord-000372-wzwpyvll	300	33	receptors	receptor	NNS
cord-000372-wzwpyvll	300	34	and	and	CC
cord-000372-wzwpyvll	300	35	carriers	carrier	NNS
cord-000372-wzwpyvll	300	36	[	[	-LRB-
cord-000372-wzwpyvll	300	37	168	168	CD
cord-000372-wzwpyvll	300	38	,	,	,
cord-000372-wzwpyvll	300	39	169	169	CD
cord-000372-wzwpyvll	300	40	]	]	-RRB-
cord-000372-wzwpyvll	300	41	.	.	.
cord-000372-wzwpyvll	301	1	FG	FG	NNP
cord-000372-wzwpyvll	301	2	nucleoporins	nucleoporin	NNS
cord-000372-wzwpyvll	301	3	are	be	VBP
cord-000372-wzwpyvll	301	4	placed	place	VBN
cord-000372-wzwpyvll	301	5	on	on	IN
cord-000372-wzwpyvll	301	6	both	both	DT
cord-000372-wzwpyvll	301	7	cytoplasmic	cytoplasmic	JJ
cord-000372-wzwpyvll	301	8	and	and	CC
cord-000372-wzwpyvll	301	9	nucleoplasmic	nucleoplasmic	JJ
cord-000372-wzwpyvll	301	10	sides	side	NNS
cord-000372-wzwpyvll	301	11	of	of	IN
cord-000372-wzwpyvll	301	12	the	the	DT
cord-000372-wzwpyvll	301	13	NPC	NPC	NNP
cord-000372-wzwpyvll	301	14	and	and	CC
cord-000372-wzwpyvll	301	15	play	play	VB
cord-000372-wzwpyvll	301	16	a	a	DT
cord-000372-wzwpyvll	301	17	central	central	JJ
cord-000372-wzwpyvll	301	18	role	role	NN
cord-000372-wzwpyvll	301	19	in	in	IN
cord-000372-wzwpyvll	301	20	the	the	DT
cord-000372-wzwpyvll	301	21	active	active	JJ
cord-000372-wzwpyvll	301	22	transport	transport	NN
cord-000372-wzwpyvll	301	23	of	of	IN
cord-000372-wzwpyvll	301	24	macromolecules	macromolecule	NNS
cord-000372-wzwpyvll	301	25	.	.	.
cord-000372-wzwpyvll	302	1	The	the	DT
cord-000372-wzwpyvll	302	2	FG	FG	NNP
cord-000372-wzwpyvll	302	3	domains	domain	NNS
cord-000372-wzwpyvll	302	4	of	of	IN
cord-000372-wzwpyvll	302	5	nucleoporins	nucleoporin	NNS
cord-000372-wzwpyvll	302	6	are	be	VBP
cord-000372-wzwpyvll	302	7	unfolded	unfold	VBN
cord-000372-wzwpyvll	302	8	regions	region	NNS
cord-000372-wzwpyvll	302	9	that	that	WDT
cord-000372-wzwpyvll	302	10	participate	participate	VBP
cord-000372-wzwpyvll	302	11	in	in	IN
cord-000372-wzwpyvll	302	12	energy	energy	NN
cord-000372-wzwpyvll	302	13	-	-	HYPH
cord-000372-wzwpyvll	302	14	independent	independent	JJ
cord-000372-wzwpyvll	302	15	transient	transient	JJ
cord-000372-wzwpyvll	302	16	interactions	interaction	NNS
cord-000372-wzwpyvll	302	17	with	with	IN
cord-000372-wzwpyvll	302	18	the	the	DT
cord-000372-wzwpyvll	302	19	cargo	cargo	NN
cord-000372-wzwpyvll	302	20	receptors	receptor	NNS
cord-000372-wzwpyvll	302	21	during	during	IN
cord-000372-wzwpyvll	302	22	the	the	DT
cord-000372-wzwpyvll	302	23	docking	docking	NN
cord-000372-wzwpyvll	302	24	and	and	CC
cord-000372-wzwpyvll	302	25	translocation	translocation	NN
cord-000372-wzwpyvll	302	26	processes	process	NNS
cord-000372-wzwpyvll	302	27	[	[	-LRB-
cord-000372-wzwpyvll	302	28	170	170	CD
cord-000372-wzwpyvll	302	29	]	]	-RRB-
cord-000372-wzwpyvll	302	30	.	.	.
cord-000372-wzwpyvll	303	1	Nevertheless	nevertheless	RB
cord-000372-wzwpyvll	303	2	,	,	,
cord-000372-wzwpyvll	303	3	the	the	DT
cord-000372-wzwpyvll	303	4	delivery	delivery	NN
cord-000372-wzwpyvll	303	5	of	of	IN
cord-000372-wzwpyvll	303	6	the	the	DT
cord-000372-wzwpyvll	303	7	cargo	cargo	NN
cord-000372-wzwpyvll	303	8	and	and	CC
cord-000372-wzwpyvll	303	9	some	some	DT
cord-000372-wzwpyvll	303	10	of	of	IN
cord-000372-wzwpyvll	303	11	the	the	DT
cord-000372-wzwpyvll	303	12	directional	directional	JJ
cord-000372-wzwpyvll	303	13	steps	step	NNS
cord-000372-wzwpyvll	303	14	require	require	VBP
cord-000372-wzwpyvll	303	15	hydrolysis	hydrolysis	NN
cord-000372-wzwpyvll	303	16	of	of	IN
cord-000372-wzwpyvll	303	17	GTP	GTP	NNP
cord-000372-wzwpyvll	303	18	.	.	.
cord-000372-wzwpyvll	304	1	Trafficking	trafficking	NN
cord-000372-wzwpyvll	304	2	of	of	IN
cord-000372-wzwpyvll	304	3	proteins	protein	NNS
cord-000372-wzwpyvll	304	4	through	through	IN
cord-000372-wzwpyvll	304	5	NPC	NPC	NNP
cord-000372-wzwpyvll	304	6	is	be	VBZ
cord-000372-wzwpyvll	304	7	mediated	mediate	VBN
cord-000372-wzwpyvll	304	8	by	by	IN
cord-000372-wzwpyvll	304	9	a	a	DT
cord-000372-wzwpyvll	304	10	family	family	NN
cord-000372-wzwpyvll	304	11	of	of	IN
cord-000372-wzwpyvll	304	12	conserved	conserved	JJ
cord-000372-wzwpyvll	304	13	transport	transport	NN
cord-000372-wzwpyvll	304	14	receptors	receptor	NNS
cord-000372-wzwpyvll	304	15	named	name	VBN
cord-000372-wzwpyvll	304	16	karyopherins	karyopherins	NNP
cord-000372-wzwpyvll	304	17	,	,	,
cord-000372-wzwpyvll	304	18	which	which	WDT
cord-000372-wzwpyvll	304	19	recognize	recognize	VBP
cord-000372-wzwpyvll	304	20	short	short	JJ
cord-000372-wzwpyvll	304	21	peptides	peptide	NNS
cord-000372-wzwpyvll	304	22	known	know	VBN
cord-000372-wzwpyvll	304	23	as	as	IN
cord-000372-wzwpyvll	304	24	nuclear	nuclear	JJ
cord-000372-wzwpyvll	304	25	localization	localization	NN
cord-000372-wzwpyvll	304	26	signal	signal	NN
cord-000372-wzwpyvll	304	27	(	(	-LRB-
cord-000372-wzwpyvll	304	28	NLS	NLS	NNP
cord-000372-wzwpyvll	304	29	)	)	-RRB-
cord-000372-wzwpyvll	304	30	and	and	CC
cord-000372-wzwpyvll	304	31	nuclear	nuclear	JJ
cord-000372-wzwpyvll	304	32	export	export	NN
cord-000372-wzwpyvll	304	33	signal	signal	NN
cord-000372-wzwpyvll	304	34	(	(	-LRB-
cord-000372-wzwpyvll	304	35	NES	NES	NNP
cord-000372-wzwpyvll	304	36	)	)	-RRB-
cord-000372-wzwpyvll	304	37	[	[	-LRB-
cord-000372-wzwpyvll	304	38	169	169	CD
cord-000372-wzwpyvll	304	39	,	,	,
cord-000372-wzwpyvll	304	40	171	171	CD
cord-000372-wzwpyvll	304	41	]	]	-RRB-
cord-000372-wzwpyvll	304	42	.	.	.
cord-000372-wzwpyvll	305	1	In	in	IN
cord-000372-wzwpyvll	305	2	addition	addition	NN
cord-000372-wzwpyvll	305	3	,	,	,
cord-000372-wzwpyvll	305	4	Karyopherins	Karyopherins	NNP
cord-000372-wzwpyvll	305	5	also	also	RB
cord-000372-wzwpyvll	305	6	recognize	recognize	VBP
cord-000372-wzwpyvll	305	7	nucleotide	nucleotide	JJ
cord-000372-wzwpyvll	305	8	sequences	sequence	NNS
cord-000372-wzwpyvll	305	9	during	during	IN
cord-000372-wzwpyvll	305	10	the	the	DT
cord-000372-wzwpyvll	305	11	export	export	NN
cord-000372-wzwpyvll	305	12	of	of	IN
cord-000372-wzwpyvll	305	13	some	some	DT
cord-000372-wzwpyvll	305	14	classes	class	NNS
cord-000372-wzwpyvll	305	15	of	of	IN
cord-000372-wzwpyvll	305	16	RNAs	rna	NNS
cord-000372-wzwpyvll	305	17	[	[	-LRB-
cord-000372-wzwpyvll	305	18	163	163	CD
cord-000372-wzwpyvll	305	19	]	]	-RRB-
cord-000372-wzwpyvll	305	20	.	.	.
cord-000372-wzwpyvll	306	1	Due	due	IN
cord-000372-wzwpyvll	306	2	to	to	IN
cord-000372-wzwpyvll	306	3	their	-PRON-	PRP$
cord-000372-wzwpyvll	306	4	key	key	JJ
cord-000372-wzwpyvll	306	5	role	role	NN
cord-000372-wzwpyvll	306	6	,	,	,
cord-000372-wzwpyvll	306	7	Karyopherins	Karyopherins	NNP
cord-000372-wzwpyvll	306	8	involved	involve	VBN
cord-000372-wzwpyvll	306	9	in	in	IN
cord-000372-wzwpyvll	306	10	cargo	cargo	NN
cord-000372-wzwpyvll	306	11	import	import	NN
cord-000372-wzwpyvll	306	12	are	be	VBP
cord-000372-wzwpyvll	306	13	known	know	VBN
cord-000372-wzwpyvll	306	14	as	as	IN
cord-000372-wzwpyvll	306	15	importins	importin	NNS
cord-000372-wzwpyvll	306	16	and	and	CC
cord-000372-wzwpyvll	306	17	those	those	DT
cord-000372-wzwpyvll	306	18	involved	involve	VBN
cord-000372-wzwpyvll	306	19	in	in	IN
cord-000372-wzwpyvll	306	20	export	export	NN
cord-000372-wzwpyvll	306	21	are	be	VBP
cord-000372-wzwpyvll	306	22	known	know	VBN
cord-000372-wzwpyvll	306	23	as	as	IN
cord-000372-wzwpyvll	306	24	exportins	exportin	NNS
cord-000372-wzwpyvll	306	25	.	.	.
cord-000372-wzwpyvll	307	1	The	the	DT
cord-000372-wzwpyvll	307	2	RanGTP	rangtp	NN
cord-000372-wzwpyvll	307	3	cycle	cycle	NN
cord-000372-wzwpyvll	307	4	also	also	RB
cord-000372-wzwpyvll	307	5	plays	play	VBZ
cord-000372-wzwpyvll	307	6	a	a	DT
cord-000372-wzwpyvll	307	7	central	central	JJ
cord-000372-wzwpyvll	307	8	role	role	NN
cord-000372-wzwpyvll	307	9	in	in	IN
cord-000372-wzwpyvll	307	10	karyopherin	karyopherin	NNP
cord-000372-wzwpyvll	307	11	activity	activity	NN
cord-000372-wzwpyvll	307	12	and	and	CC
cord-000372-wzwpyvll	307	13	,	,	,
cord-000372-wzwpyvll	307	14	therefore	therefore	RB
cord-000372-wzwpyvll	307	15	,	,	,
cord-000372-wzwpyvll	307	16	in	in	IN
cord-000372-wzwpyvll	307	17	trafficking	trafficking	NN
cord-000372-wzwpyvll	307	18	of	of	IN
cord-000372-wzwpyvll	307	19	macromolecules	macromolecule	NNS
cord-000372-wzwpyvll	307	20	through	through	IN
cord-000372-wzwpyvll	307	21	the	the	DT
cord-000372-wzwpyvll	307	22	NPC	NPC	NNP
cord-000372-wzwpyvll	307	23	.	.	.
cord-000372-wzwpyvll	308	1	Importins	importin	NNS
cord-000372-wzwpyvll	308	2	bind	bind	VBP
cord-000372-wzwpyvll	308	3	the	the	DT
cord-000372-wzwpyvll	308	4	cargo	cargo	NN
cord-000372-wzwpyvll	308	5	in	in	IN
cord-000372-wzwpyvll	308	6	the	the	DT
cord-000372-wzwpyvll	308	7	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	308	8	and	and	CC
cord-000372-wzwpyvll	308	9	release	release	VB
cord-000372-wzwpyvll	308	10	it	-PRON-	PRP
cord-000372-wzwpyvll	308	11	on	on	IN
cord-000372-wzwpyvll	308	12	binding	bind	VBG
cord-000372-wzwpyvll	308	13	to	to	IN
cord-000372-wzwpyvll	308	14	RanGTP	rangtp	NN
cord-000372-wzwpyvll	308	15	in	in	IN
cord-000372-wzwpyvll	308	16	the	the	DT
cord-000372-wzwpyvll	308	17	nucleus	nucleus	NN
cord-000372-wzwpyvll	308	18	.	.	.
cord-000372-wzwpyvll	309	1	In	in	IN
cord-000372-wzwpyvll	309	2	contrast	contrast	NN
cord-000372-wzwpyvll	309	3	,	,	,
cord-000372-wzwpyvll	309	4	exportins	exportin	NNS
cord-000372-wzwpyvll	309	5	bind	bind	VBP
cord-000372-wzwpyvll	309	6	the	the	DT
cord-000372-wzwpyvll	309	7	cargo	cargo	NN
cord-000372-wzwpyvll	309	8	in	in	IN
cord-000372-wzwpyvll	309	9	the	the	DT
cord-000372-wzwpyvll	309	10	nucleus	nucleus	NN
cord-000372-wzwpyvll	309	11	together	together	RB
cord-000372-wzwpyvll	309	12	with	with	IN
cord-000372-wzwpyvll	309	13	RanGTP	rangtp	NN
cord-000372-wzwpyvll	309	14	;	;	:
cord-000372-wzwpyvll	309	15	and	and	CC
cord-000372-wzwpyvll	309	16	then	then	RB
cord-000372-wzwpyvll	309	17	the	the	DT
cord-000372-wzwpyvll	309	18	Ran	ran	NN
cord-000372-wzwpyvll	309	19	-	-	HYPH
cord-000372-wzwpyvll	309	20	associated	associate	VBN
cord-000372-wzwpyvll	309	21	GTP	GTP	NNP
cord-000372-wzwpyvll	309	22	is	be	VBZ
cord-000372-wzwpyvll	309	23	hydrolyzed	hydrolyze	VBN
cord-000372-wzwpyvll	309	24	in	in	IN
cord-000372-wzwpyvll	309	25	the	the	DT
cord-000372-wzwpyvll	309	26	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	309	27	by	by	IN
cord-000372-wzwpyvll	310	1	RanGAP	rangap	NN
cord-000372-wzwpyvll	310	2	and	and	CC
cord-000372-wzwpyvll	310	3	cargo	cargo	NN
cord-000372-wzwpyvll	310	4	is	be	VBZ
cord-000372-wzwpyvll	310	5	liberated	liberate	VBN
cord-000372-wzwpyvll	310	6	[	[	-LRB-
cord-000372-wzwpyvll	310	7	163	163	CD
cord-000372-wzwpyvll	310	8	,	,	,
cord-000372-wzwpyvll	310	9	164	164	CD
cord-000372-wzwpyvll	310	10	]	]	-RRB-
cord-000372-wzwpyvll	310	11	.	.	.
cord-000372-wzwpyvll	311	1	Proteins	protein	NNS
cord-000372-wzwpyvll	311	2	containing	contain	VBG
cord-000372-wzwpyvll	311	3	constitutively	constitutively	RB
cord-000372-wzwpyvll	311	4	active	active	JJ
cord-000372-wzwpyvll	311	5	NLS	nls	NN
cord-000372-wzwpyvll	311	6	are	be	VBP
cord-000372-wzwpyvll	311	7	predominantly	predominantly	RB
cord-000372-wzwpyvll	311	8	nuclear	nuclear	JJ
cord-000372-wzwpyvll	311	9	;	;	:
cord-000372-wzwpyvll	311	10	but	but	CC
cord-000372-wzwpyvll	311	11	in	in	IN
cord-000372-wzwpyvll	311	12	some	some	DT
cord-000372-wzwpyvll	311	13	cases	case	NNS
cord-000372-wzwpyvll	311	14	,	,	,
cord-000372-wzwpyvll	311	15	the	the	DT
cord-000372-wzwpyvll	311	16	accessibility	accessibility	NN
cord-000372-wzwpyvll	311	17	of	of	IN
cord-000372-wzwpyvll	311	18	NLS	NLS	NNP
cord-000372-wzwpyvll	311	19	or	or	CC
cord-000372-wzwpyvll	311	20	the	the	DT
cord-000372-wzwpyvll	311	21	NLS	nls	NN
cord-000372-wzwpyvll	311	22	itself	-PRON-	PRP
cord-000372-wzwpyvll	311	23	is	be	VBZ
cord-000372-wzwpyvll	311	24	modified	modify	VBN
cord-000372-wzwpyvll	311	25	to	to	TO
cord-000372-wzwpyvll	311	26	selectively	selectively	RB
cord-000372-wzwpyvll	311	27	regulate	regulate	VB
cord-000372-wzwpyvll	311	28	the	the	DT
cord-000372-wzwpyvll	311	29	localization	localization	NN
cord-000372-wzwpyvll	311	30	of	of	IN
cord-000372-wzwpyvll	311	31	the	the	DT
cord-000372-wzwpyvll	311	32	protein	protein	NN
cord-000372-wzwpyvll	311	33	[	[	-LRB-
cord-000372-wzwpyvll	311	34	172	172	CD
cord-000372-wzwpyvll	311	35	]	]	-RRB-
cord-000372-wzwpyvll	311	36	.	.	.
cord-000372-wzwpyvll	312	1	A	a	DT
cord-000372-wzwpyvll	312	2	similar	similar	JJ
cord-000372-wzwpyvll	312	3	regulatory	regulatory	JJ
cord-000372-wzwpyvll	312	4	mechanism	mechanism	NN
cord-000372-wzwpyvll	312	5	is	be	VBZ
cord-000372-wzwpyvll	312	6	also	also	RB
cord-000372-wzwpyvll	312	7	exerted	exert	VBN
cord-000372-wzwpyvll	312	8	for	for	IN
cord-000372-wzwpyvll	312	9	control	control	NN
cord-000372-wzwpyvll	312	10	of	of	IN
cord-000372-wzwpyvll	312	11	NES	NES	NNP
cord-000372-wzwpyvll	312	12	activity	activity	NN
cord-000372-wzwpyvll	312	13	[	[	-LRB-
cord-000372-wzwpyvll	312	14	173	173	CD
cord-000372-wzwpyvll	312	15	]	]	-RRB-
cord-000372-wzwpyvll	312	16	.	.	.
cord-000372-wzwpyvll	313	1	For	for	IN
cord-000372-wzwpyvll	313	2	example	example	NN
cord-000372-wzwpyvll	313	3	,	,	,
cord-000372-wzwpyvll	313	4	the	the	DT
cord-000372-wzwpyvll	313	5	NLS	nls	NN
cord-000372-wzwpyvll	313	6	of	of	IN
cord-000372-wzwpyvll	313	7	the	the	DT
cord-000372-wzwpyvll	313	8	transcription	transcription	NN
cord-000372-wzwpyvll	313	9	factor	factor	NN
cord-000372-wzwpyvll	313	10	NFκB	NFκB	NNP
cord-000372-wzwpyvll	313	11	is	be	VBZ
cord-000372-wzwpyvll	313	12	masked	mask	VBN
cord-000372-wzwpyvll	313	13	by	by	IN
cord-000372-wzwpyvll	313	14	the	the	DT
cord-000372-wzwpyvll	313	15	interaction	interaction	NN
cord-000372-wzwpyvll	313	16	with	with	IN
cord-000372-wzwpyvll	313	17	the	the	DT
cord-000372-wzwpyvll	313	18	inhibitor	inhibitor	NN
cord-000372-wzwpyvll	313	19	IκBα	IκBα	NNP
cord-000372-wzwpyvll	313	20	.	.	.
cord-000372-wzwpyvll	314	1	However	however	RB
cord-000372-wzwpyvll	314	2	,	,	,
cord-000372-wzwpyvll	314	3	IκBα	IκBα	NNP
cord-000372-wzwpyvll	314	4	is	be	VBZ
cord-000372-wzwpyvll	314	5	degraded	degrade	VBN
cord-000372-wzwpyvll	314	6	on	on	IN
cord-000372-wzwpyvll	314	7	proinflammatory	proinflammatory	JJ
cord-000372-wzwpyvll	314	8	stimuli	stimulus	NNS
cord-000372-wzwpyvll	314	9	,	,	,
cord-000372-wzwpyvll	314	10	exposing	expose	VBG
cord-000372-wzwpyvll	314	11	the	the	DT
cord-000372-wzwpyvll	314	12	NLS	nls	NN
cord-000372-wzwpyvll	314	13	of	of	IN
cord-000372-wzwpyvll	314	14	NFκB	NFκB	NNP
cord-000372-wzwpyvll	314	15	for	for	IN
cord-000372-wzwpyvll	314	16	importin	importin	NNP
cord-000372-wzwpyvll	314	17	recognition	recognition	NN
cord-000372-wzwpyvll	314	18	.	.	.
cord-000372-wzwpyvll	315	1	Therefore	therefore	RB
cord-000372-wzwpyvll	315	2	,	,	,
cord-000372-wzwpyvll	315	3	under	under	IN
cord-000372-wzwpyvll	315	4	proinflammatory	proinflammatory	JJ
cord-000372-wzwpyvll	315	5	conditions	condition	NNS
cord-000372-wzwpyvll	315	6	,	,	,
cord-000372-wzwpyvll	315	7	NFκB	NFκB	NNP
cord-000372-wzwpyvll	315	8	is	be	VBZ
cord-000372-wzwpyvll	315	9	imported	import	VBN
cord-000372-wzwpyvll	315	10	to	to	IN
cord-000372-wzwpyvll	315	11	the	the	DT
cord-000372-wzwpyvll	315	12	nucleus	nucleus	NN
cord-000372-wzwpyvll	315	13	,	,	,
cord-000372-wzwpyvll	315	14	where	where	WRB
cord-000372-wzwpyvll	315	15	it	-PRON-	PRP
cord-000372-wzwpyvll	315	16	triggers	trigger	VBZ
cord-000372-wzwpyvll	315	17	a	a	DT
cord-000372-wzwpyvll	315	18	specific	specific	JJ
cord-000372-wzwpyvll	315	19	gene	gene	NN
cord-000372-wzwpyvll	315	20	response	response	NN
cord-000372-wzwpyvll	315	21	[	[	-LRB-
cord-000372-wzwpyvll	315	22	172	172	CD
cord-000372-wzwpyvll	315	23	]	]	-RRB-
cord-000372-wzwpyvll	315	24	.	.	.
cord-000372-wzwpyvll	316	1	In	in	IN
cord-000372-wzwpyvll	316	2	addition	addition	NN
cord-000372-wzwpyvll	316	3	to	to	IN
cord-000372-wzwpyvll	316	4	"	"	``
cord-000372-wzwpyvll	316	5	masking	mask	VBG
cord-000372-wzwpyvll	316	6	strategies	strategy	NNS
cord-000372-wzwpyvll	316	7	,	,	,
cord-000372-wzwpyvll	316	8	"	"	''
cord-000372-wzwpyvll	316	9	phosphorylation	phosphorylation	NN
cord-000372-wzwpyvll	316	10	,	,	,
cord-000372-wzwpyvll	316	11	ubiquitination	ubiquitination	NN
cord-000372-wzwpyvll	316	12	or	or	CC
cord-000372-wzwpyvll	316	13	methylation	methylation	NN
cord-000372-wzwpyvll	316	14	of	of	IN
cord-000372-wzwpyvll	316	15	NLS	NLS	NNP
cord-000372-wzwpyvll	316	16	or	or	CC
cord-000372-wzwpyvll	316	17	NES	NES	NNP
cord-000372-wzwpyvll	316	18	also	also	RB
cord-000372-wzwpyvll	316	19	influences	influence	VBZ
cord-000372-wzwpyvll	316	20	(	(	-LRB-
cord-000372-wzwpyvll	316	21	negatively	negatively	RB
cord-000372-wzwpyvll	316	22	or	or	CC
cord-000372-wzwpyvll	316	23	positively	positively	RB
cord-000372-wzwpyvll	316	24	)	)	-RRB-
cord-000372-wzwpyvll	317	1	their	-PRON-	PRP$
cord-000372-wzwpyvll	317	2	recognition	recognition	NN
cord-000372-wzwpyvll	317	3	by	by	IN
cord-000372-wzwpyvll	317	4	importins	importin	NNS
cord-000372-wzwpyvll	317	5	or	or	CC
cord-000372-wzwpyvll	317	6	exportins	exportin	NNS
cord-000372-wzwpyvll	317	7	.	.	.
cord-000372-wzwpyvll	318	1	Therefore	therefore	RB
cord-000372-wzwpyvll	318	2	,	,	,
cord-000372-wzwpyvll	318	3	trafficking	trafficking	NN
cord-000372-wzwpyvll	318	4	of	of	IN
cord-000372-wzwpyvll	318	5	proteins	protein	NNS
cord-000372-wzwpyvll	318	6	between	between	IN
cord-000372-wzwpyvll	318	7	nucleus	nucleus	NN
cord-000372-wzwpyvll	318	8	and	and	CC
cord-000372-wzwpyvll	318	9	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	318	10	could	could	MD
cord-000372-wzwpyvll	318	11	be	be	VB
cord-000372-wzwpyvll	318	12	finely	finely	RB
cord-000372-wzwpyvll	318	13	regulated	regulate	VBN
cord-000372-wzwpyvll	318	14	by	by	IN
cord-000372-wzwpyvll	318	15	posttranslational	posttranslational	JJ
cord-000372-wzwpyvll	318	16	modifications	modification	NNS
cord-000372-wzwpyvll	318	17	in	in	IN
cord-000372-wzwpyvll	318	18	the	the	DT
cord-000372-wzwpyvll	318	19	NLS	NLS	NNP
cord-000372-wzwpyvll	318	20	and	and	CC
cord-000372-wzwpyvll	318	21	NES	NES	NNP
cord-000372-wzwpyvll	318	22	[	[	-LRB-
cord-000372-wzwpyvll	318	23	164	164	CD
cord-000372-wzwpyvll	318	24	,	,	,
cord-000372-wzwpyvll	318	25	174	174	CD
cord-000372-wzwpyvll	318	26	]	]	-RRB-
cord-000372-wzwpyvll	318	27	.	.	.
cord-000372-wzwpyvll	319	1	Conceptually	conceptually	RB
cord-000372-wzwpyvll	319	2	,	,	,
cord-000372-wzwpyvll	319	3	export	export	NN
cord-000372-wzwpyvll	319	4	of	of	IN
cord-000372-wzwpyvll	319	5	most	most	JJS
cord-000372-wzwpyvll	319	6	of	of	IN
cord-000372-wzwpyvll	319	7	nuclear	nuclear	JJ
cord-000372-wzwpyvll	319	8	RNA	RNA	NNP
cord-000372-wzwpyvll	319	9	follows	follow	VBZ
cord-000372-wzwpyvll	319	10	a	a	DT
cord-000372-wzwpyvll	319	11	similar	similar	JJ
cord-000372-wzwpyvll	319	12	mechanism	mechanism	NN
cord-000372-wzwpyvll	319	13	to	to	IN
cord-000372-wzwpyvll	319	14	that	that	DT
cord-000372-wzwpyvll	319	15	described	describe	VBN
cord-000372-wzwpyvll	319	16	above	above	RB
cord-000372-wzwpyvll	319	17	for	for	IN
cord-000372-wzwpyvll	319	18	protein	protein	NN
cord-000372-wzwpyvll	319	19	trafficking	trafficking	NN
cord-000372-wzwpyvll	319	20	.	.	.
cord-000372-wzwpyvll	320	1	This	this	DT
cord-000372-wzwpyvll	320	2	process	process	NN
cord-000372-wzwpyvll	320	3	also	also	RB
cord-000372-wzwpyvll	320	4	involves	involve	VBZ
cord-000372-wzwpyvll	320	5	cargo	cargo	NN
cord-000372-wzwpyvll	320	6	receptors	receptor	NNS
cord-000372-wzwpyvll	320	7	,	,	,
cord-000372-wzwpyvll	320	8	export	export	NN
cord-000372-wzwpyvll	320	9	factors	factor	NNS
cord-000372-wzwpyvll	320	10	,	,	,
cord-000372-wzwpyvll	320	11	and	and	CC
cord-000372-wzwpyvll	320	12	nucleoporins	nucleoporin	NNS
cord-000372-wzwpyvll	320	13	to	to	TO
cord-000372-wzwpyvll	320	14	deliver	deliver	VB
cord-000372-wzwpyvll	320	15	mature	mature	NNP
cord-000372-wzwpyvll	320	16	RNA	RNA	NNP
cord-000372-wzwpyvll	320	17	to	to	IN
cord-000372-wzwpyvll	320	18	the	the	DT
cord-000372-wzwpyvll	320	19	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	320	20	,	,	,
cord-000372-wzwpyvll	320	21	but	but	CC
cord-000372-wzwpyvll	320	22	in	in	IN
cord-000372-wzwpyvll	320	23	this	this	DT
cord-000372-wzwpyvll	320	24	case	case	NN
cord-000372-wzwpyvll	320	25	,	,	,
cord-000372-wzwpyvll	320	26	structure	structure	NN
cord-000372-wzwpyvll	320	27	and	and	CC
cord-000372-wzwpyvll	320	28	function	function	NN
cord-000372-wzwpyvll	320	29	of	of	IN
cord-000372-wzwpyvll	320	30	nuclear	nuclear	JJ
cord-000372-wzwpyvll	320	31	export	export	NN
cord-000372-wzwpyvll	320	32	signals	signal	NNS
cord-000372-wzwpyvll	320	33	are	be	VBP
cord-000372-wzwpyvll	320	34	not	not	RB
cord-000372-wzwpyvll	320	35	well	well	RB
cord-000372-wzwpyvll	320	36	understood	understand	VBN
cord-000372-wzwpyvll	320	37	.	.	.
cord-000372-wzwpyvll	321	1	Aminoacylated	Aminoacylated	NNP
cord-000372-wzwpyvll	321	2	tRNAs	trna	NNS
cord-000372-wzwpyvll	321	3	are	be	VBP
cord-000372-wzwpyvll	321	4	necessary	necessary	JJ
cord-000372-wzwpyvll	321	5	in	in	IN
cord-000372-wzwpyvll	321	6	the	the	DT
cord-000372-wzwpyvll	321	7	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	321	8	for	for	IN
cord-000372-wzwpyvll	321	9	protein	protein	NN
cord-000372-wzwpyvll	321	10	synthesis	synthesis	NN
cord-000372-wzwpyvll	321	11	,	,	,
cord-000372-wzwpyvll	321	12	but	but	CC
cord-000372-wzwpyvll	321	13	tRNAs	trna	NNS
cord-000372-wzwpyvll	321	14	are	be	VBP
cord-000372-wzwpyvll	321	15	transcribed	transcribe	VBN
cord-000372-wzwpyvll	321	16	in	in	IN
cord-000372-wzwpyvll	321	17	the	the	DT
cord-000372-wzwpyvll	321	18	nucleus	nucleus	NN
cord-000372-wzwpyvll	321	19	.	.	.
cord-000372-wzwpyvll	322	1	tRNA	tRNA	NNP
cord-000372-wzwpyvll	322	2	export	export	NN
cord-000372-wzwpyvll	322	3	to	to	IN
cord-000372-wzwpyvll	322	4	the	the	DT
cord-000372-wzwpyvll	322	5	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	322	6	is	be	VBZ
cord-000372-wzwpyvll	322	7	mediated	mediate	VBN
cord-000372-wzwpyvll	322	8	by	by	IN
cord-000372-wzwpyvll	322	9	exportin	exportin	NN
cord-000372-wzwpyvll	322	10	-	-	HYPH
cord-000372-wzwpyvll	322	11	t	t	NNP
cord-000372-wzwpyvll	322	12	,	,	,
cord-000372-wzwpyvll	322	13	which	which	WDT
cord-000372-wzwpyvll	322	14	belongs	belong	VBZ
cord-000372-wzwpyvll	322	15	to	to	IN
cord-000372-wzwpyvll	322	16	the	the	DT
cord-000372-wzwpyvll	322	17	karyopherin	karyopherin	NNP
cord-000372-wzwpyvll	322	18	family	family	NN
cord-000372-wzwpyvll	322	19	.	.	.
cord-000372-wzwpyvll	323	1	Exportin	Exportin	NNP
cord-000372-wzwpyvll	323	2	-	-	HYPH
cord-000372-wzwpyvll	323	3	t	t	NN
cord-000372-wzwpyvll	323	4	forms	form	VBZ
cord-000372-wzwpyvll	323	5	a	a	DT
cord-000372-wzwpyvll	323	6	complex	complex	NN
cord-000372-wzwpyvll	323	7	together	together	RB
cord-000372-wzwpyvll	323	8	with	with	IN
cord-000372-wzwpyvll	323	9	RanGTP	rangtp	NN
cord-000372-wzwpyvll	323	10	in	in	IN
cord-000372-wzwpyvll	323	11	the	the	DT
cord-000372-wzwpyvll	323	12	nucleus	nucleus	NN
cord-000372-wzwpyvll	323	13	,	,	,
cord-000372-wzwpyvll	323	14	and	and	CC
cord-000372-wzwpyvll	323	15	once	once	IN
cord-000372-wzwpyvll	323	16	the	the	DT
cord-000372-wzwpyvll	323	17	exportin	exportin	NNP
cord-000372-wzwpyvll	323	18	-	-	HYPH
cord-000372-wzwpyvll	323	19	t	t	NN
cord-000372-wzwpyvll	323	20	-	-	HYPH
cord-000372-wzwpyvll	323	21	RanGTP	rangtp	NN
cord-000372-wzwpyvll	323	22	-	-	HYPH
cord-000372-wzwpyvll	323	23	tRNA	trna	NN
cord-000372-wzwpyvll	323	24	complex	complex	NN
cord-000372-wzwpyvll	323	25	reaches	reach	VBZ
cord-000372-wzwpyvll	323	26	the	the	DT
cord-000372-wzwpyvll	323	27	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	323	28	,	,	,
cord-000372-wzwpyvll	323	29	RanGAP	rangap	NN
cord-000372-wzwpyvll	323	30	induces	induce	VBZ
cord-000372-wzwpyvll	323	31	the	the	DT
cord-000372-wzwpyvll	323	32	hydrolysis	hydrolysis	NN
cord-000372-wzwpyvll	323	33	of	of	IN
cord-000372-wzwpyvll	323	34	the	the	DT
cord-000372-wzwpyvll	323	35	Ran	Ran	NNP
cord-000372-wzwpyvll	323	36	-	-	HYPH
cord-000372-wzwpyvll	323	37	associated	associate	VBN
cord-000372-wzwpyvll	323	38	GTP	GTP	NNP
cord-000372-wzwpyvll	323	39	and	and	CC
cord-000372-wzwpyvll	323	40	the	the	DT
cord-000372-wzwpyvll	323	41	release	release	NN
cord-000372-wzwpyvll	323	42	of	of	IN
cord-000372-wzwpyvll	323	43	the	the	DT
cord-000372-wzwpyvll	323	44	tRNA	tRNA	NNP
cord-000372-wzwpyvll	323	45	[	[	-LRB-
cord-000372-wzwpyvll	323	46	175	175	CD
cord-000372-wzwpyvll	323	47	,	,	,
cord-000372-wzwpyvll	323	48	176	176	CD
cord-000372-wzwpyvll	323	49	]	]	-RRB-
cord-000372-wzwpyvll	323	50	.	.	.
cord-000372-wzwpyvll	324	1	It	-PRON-	PRP
cord-000372-wzwpyvll	324	2	has	have	VBZ
cord-000372-wzwpyvll	324	3	been	be	VBN
cord-000372-wzwpyvll	324	4	proposed	propose	VBN
cord-000372-wzwpyvll	324	5	that	that	IN
cord-000372-wzwpyvll	324	6	exportin-5	exportin-5	NNP
cord-000372-wzwpyvll	324	7	could	could	MD
cord-000372-wzwpyvll	324	8	act	act	VB
cord-000372-wzwpyvll	324	9	as	as	IN
cord-000372-wzwpyvll	324	10	an	an	DT
cord-000372-wzwpyvll	324	11	auxiliary	auxiliary	JJ
cord-000372-wzwpyvll	324	12	protein	protein	NN
cord-000372-wzwpyvll	324	13	in	in	IN
cord-000372-wzwpyvll	324	14	this	this	DT
cord-000372-wzwpyvll	324	15	process	process	NN
cord-000372-wzwpyvll	324	16	[	[	-LRB-
cord-000372-wzwpyvll	324	17	177	177	CD
cord-000372-wzwpyvll	324	18	]	]	-RRB-
cord-000372-wzwpyvll	324	19	.	.	.
cord-000372-wzwpyvll	325	1	However	however	RB
cord-000372-wzwpyvll	325	2	,	,	,
cord-000372-wzwpyvll	325	3	later	later	RB
cord-000372-wzwpyvll	325	4	reports	report	NNS
cord-000372-wzwpyvll	325	5	in	in	IN
cord-000372-wzwpyvll	325	6	yeast	yeast	NN
cord-000372-wzwpyvll	325	7	have	have	VBP
cord-000372-wzwpyvll	325	8	opened	open	VBN
cord-000372-wzwpyvll	325	9	the	the	DT
cord-000372-wzwpyvll	325	10	possibility	possibility	NN
cord-000372-wzwpyvll	325	11	of	of	IN
cord-000372-wzwpyvll	325	12	alternative	alternative	JJ
cord-000372-wzwpyvll	325	13	pathways	pathway	NNS
cord-000372-wzwpyvll	325	14	for	for	IN
cord-000372-wzwpyvll	325	15	tRNA	tRNA	NNP
cord-000372-wzwpyvll	325	16	nuclear	nuclear	JJ
cord-000372-wzwpyvll	325	17	export	export	NN
cord-000372-wzwpyvll	325	18	[	[	-LRB-
cord-000372-wzwpyvll	325	19	163	163	CD
cord-000372-wzwpyvll	325	20	]	]	-RRB-
cord-000372-wzwpyvll	325	21	.	.	.
cord-000372-wzwpyvll	326	1	Traffic	traffic	NN
cord-000372-wzwpyvll	326	2	of	of	IN
cord-000372-wzwpyvll	326	3	snRNA	snrna	NN
cord-000372-wzwpyvll	326	4	follows	follow	VBZ
cord-000372-wzwpyvll	326	5	a	a	DT
cord-000372-wzwpyvll	326	6	complex	complex	JJ
cord-000372-wzwpyvll	326	7	mechanism	mechanism	NN
cord-000372-wzwpyvll	326	8	involving	involve	VBG
cord-000372-wzwpyvll	326	9	adaptor	adaptor	NN
cord-000372-wzwpyvll	326	10	proteins	protein	NNS
cord-000372-wzwpyvll	326	11	.	.	.
cord-000372-wzwpyvll	327	1	snRNAs	snrna	NNS
cord-000372-wzwpyvll	327	2	are	be	VBP
cord-000372-wzwpyvll	327	3	transcribed	transcribe	VBN
cord-000372-wzwpyvll	327	4	by	by	IN
cord-000372-wzwpyvll	327	5	the	the	DT
cord-000372-wzwpyvll	327	6	RNA	RNA	NNP
cord-000372-wzwpyvll	327	7	polymerase	polymerase	NN
cord-000372-wzwpyvll	327	8	(	(	-LRB-
cord-000372-wzwpyvll	327	9	Pol	Pol	NNP
cord-000372-wzwpyvll	327	10	)	)	-RRB-
cord-000372-wzwpyvll	327	11	II	II	NNP
cord-000372-wzwpyvll	327	12	(	(	-LRB-
cord-000372-wzwpyvll	327	13	with	with	IN
cord-000372-wzwpyvll	327	14	the	the	DT
cord-000372-wzwpyvll	327	15	exception	exception	NN
cord-000372-wzwpyvll	327	16	of	of	IN
cord-000372-wzwpyvll	327	17	U6	U6	NNP
cord-000372-wzwpyvll	327	18	snRNA	snrna	NN
cord-000372-wzwpyvll	327	19	which	which	WDT
cord-000372-wzwpyvll	327	20	is	be	VBZ
cord-000372-wzwpyvll	327	21	produced	produce	VBN
cord-000372-wzwpyvll	327	22	by	by	IN
cord-000372-wzwpyvll	328	1	PolIII	PolIII	NNP
cord-000372-wzwpyvll	328	2	)	)	-RRB-
cord-000372-wzwpyvll	329	1	and	and	CC
cord-000372-wzwpyvll	329	2	then	then	RB
cord-000372-wzwpyvll	329	3	they	-PRON-	PRP
cord-000372-wzwpyvll	329	4	are	be	VBP
cord-000372-wzwpyvll	329	5	capped	cap	VBN
cord-000372-wzwpyvll	329	6	but	but	CC
cord-000372-wzwpyvll	329	7	not	not	RB
cord-000372-wzwpyvll	329	8	polyadenylated	polyadenylate	VBN
cord-000372-wzwpyvll	329	9	.	.	.
cord-000372-wzwpyvll	330	1	Cap	cap	NN
cord-000372-wzwpyvll	330	2	-	-	HYPH
cord-000372-wzwpyvll	330	3	binding	bind	VBG
cord-000372-wzwpyvll	330	4	proteins	protein	NNS
cord-000372-wzwpyvll	330	5	(	(	-LRB-
cord-000372-wzwpyvll	330	6	CBP	CBP	NNP
cord-000372-wzwpyvll	330	7	)	)	-RRB-
cord-000372-wzwpyvll	331	1	80	80	CD
cord-000372-wzwpyvll	331	2	and	and	CC
cord-000372-wzwpyvll	331	3	20	20	CD
cord-000372-wzwpyvll	331	4	interact	interact	VB
cord-000372-wzwpyvll	331	5	with	with	IN
cord-000372-wzwpyvll	331	6	the	the	DT
cord-000372-wzwpyvll	331	7	cap	cap	NN
cord-000372-wzwpyvll	331	8	of	of	IN
cord-000372-wzwpyvll	331	9	snRNAs	snRNAs	NNPS
cord-000372-wzwpyvll	331	10	in	in	IN
cord-000372-wzwpyvll	331	11	the	the	DT
cord-000372-wzwpyvll	331	12	nucleus	nucleus	NN
cord-000372-wzwpyvll	331	13	and	and	CC
cord-000372-wzwpyvll	331	14	recruit	recruit	VB
cord-000372-wzwpyvll	331	15	an	an	DT
cord-000372-wzwpyvll	331	16	export	export	NN
cord-000372-wzwpyvll	331	17	adaptor	adaptor	NN
cord-000372-wzwpyvll	331	18	known	know	VBN
cord-000372-wzwpyvll	331	19	as	as	IN
cord-000372-wzwpyvll	331	20	PHAX	PHAX	NNP
cord-000372-wzwpyvll	331	21	[	[	-LRB-
cord-000372-wzwpyvll	331	22	178	178	CD
cord-000372-wzwpyvll	331	23	]	]	-RRB-
cord-000372-wzwpyvll	331	24	.	.	.
cord-000372-wzwpyvll	332	1	This	this	DT
cord-000372-wzwpyvll	332	2	adaptor	adaptor	NN
cord-000372-wzwpyvll	332	3	is	be	VBZ
cord-000372-wzwpyvll	332	4	phosphorylated	phosphorylate	VBN
cord-000372-wzwpyvll	332	5	and	and	CC
cord-000372-wzwpyvll	332	6	in	in	IN
cord-000372-wzwpyvll	332	7	this	this	DT
cord-000372-wzwpyvll	332	8	state	state	NN
cord-000372-wzwpyvll	332	9	,	,	,
cord-000372-wzwpyvll	332	10	it	-PRON-	PRP
cord-000372-wzwpyvll	332	11	is	be	VBZ
cord-000372-wzwpyvll	332	12	able	able	JJ
cord-000372-wzwpyvll	332	13	to	to	TO
cord-000372-wzwpyvll	332	14	interact	interact	VB
cord-000372-wzwpyvll	332	15	with	with	IN
cord-000372-wzwpyvll	332	16	CRM1	CRM1	NNP
cord-000372-wzwpyvll	332	17	,	,	,
cord-000372-wzwpyvll	332	18	another	another	DT
cord-000372-wzwpyvll	332	19	member	member	NN
cord-000372-wzwpyvll	332	20	of	of	IN
cord-000372-wzwpyvll	332	21	karyopherin	karyopherin	NNP
cord-000372-wzwpyvll	332	22	family	family	NN
cord-000372-wzwpyvll	332	23	.	.	.
cord-000372-wzwpyvll	333	1	This	this	DT
cord-000372-wzwpyvll	333	2	interaction	interaction	NN
cord-000372-wzwpyvll	333	3	together	together	RB
cord-000372-wzwpyvll	333	4	with	with	IN
cord-000372-wzwpyvll	333	5	the	the	DT
cord-000372-wzwpyvll	333	6	joining	joining	NN
cord-000372-wzwpyvll	333	7	of	of	IN
cord-000372-wzwpyvll	333	8	RanGTP	rangtp	NN
cord-000372-wzwpyvll	333	9	is	be	VBZ
cord-000372-wzwpyvll	333	10	essential	essential	JJ
cord-000372-wzwpyvll	333	11	for	for	IN
cord-000372-wzwpyvll	333	12	snRNA	snRNA	``
cord-000372-wzwpyvll	333	13	trafficking	traffic	VBG
cord-000372-wzwpyvll	333	14	[	[	-LRB-
cord-000372-wzwpyvll	333	15	163	163	CD
cord-000372-wzwpyvll	333	16	]	]	-RRB-
cord-000372-wzwpyvll	333	17	.	.	.
cord-000372-wzwpyvll	334	1	Hydrolysis	hydrolysis	NN
cord-000372-wzwpyvll	334	2	of	of	IN
cord-000372-wzwpyvll	334	3	RanGTP	RanGTP	NNS
cord-000372-wzwpyvll	334	4	and	and	CC
cord-000372-wzwpyvll	334	5	dephosphorylation	dephosphorylation	NN
cord-000372-wzwpyvll	334	6	of	of	IN
cord-000372-wzwpyvll	334	7	PHAX	PHAX	NNP
cord-000372-wzwpyvll	334	8	lead	lead	NN
cord-000372-wzwpyvll	334	9	to	to	IN
cord-000372-wzwpyvll	334	10	the	the	DT
cord-000372-wzwpyvll	334	11	release	release	NN
cord-000372-wzwpyvll	334	12	of	of	IN
cord-000372-wzwpyvll	334	13	the	the	DT
cord-000372-wzwpyvll	334	14	snRNA	snrna	NN
cord-000372-wzwpyvll	334	15	in	in	IN
cord-000372-wzwpyvll	334	16	the	the	DT
cord-000372-wzwpyvll	334	17	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	334	18	.	.	.
cord-000372-wzwpyvll	335	1	Ribosomal	ribosomal	JJ
cord-000372-wzwpyvll	335	2	proteins	protein	NNS
cord-000372-wzwpyvll	335	3	are	be	VBP
cord-000372-wzwpyvll	335	4	assembled	assemble	VBN
cord-000372-wzwpyvll	335	5	together	together	RB
cord-000372-wzwpyvll	335	6	with	with	IN
cord-000372-wzwpyvll	335	7	the	the	DT
cord-000372-wzwpyvll	335	8	different	different	JJ
cord-000372-wzwpyvll	335	9	rRNAs	rrna	NNS
cord-000372-wzwpyvll	336	1	in	in	IN
cord-000372-wzwpyvll	336	2	the	the	DT
cord-000372-wzwpyvll	336	3	nucleolus	nucleolus	NN
cord-000372-wzwpyvll	336	4	following	follow	VBG
cord-000372-wzwpyvll	336	5	a	a	DT
cord-000372-wzwpyvll	336	6	complex	complex	JJ
cord-000372-wzwpyvll	336	7	process	process	NN
cord-000372-wzwpyvll	336	8	of	of	IN
cord-000372-wzwpyvll	336	9	maturation	maturation	NN
cord-000372-wzwpyvll	336	10	to	to	TO
cord-000372-wzwpyvll	336	11	give	give	VB
cord-000372-wzwpyvll	336	12	rise	rise	NN
cord-000372-wzwpyvll	336	13	to	to	IN
cord-000372-wzwpyvll	336	14	the	the	DT
cord-000372-wzwpyvll	336	15	ribosomal	ribosomal	JJ
cord-000372-wzwpyvll	336	16	subunits	subunit	NNS
cord-000372-wzwpyvll	336	17	40S	40s	CD
cord-000372-wzwpyvll	336	18	and	and	CC
cord-000372-wzwpyvll	336	19	60S.	60s.	CD
cord-000372-wzwpyvll	336	20	Although	although	IN
cord-000372-wzwpyvll	336	21	is	be	VBZ
cord-000372-wzwpyvll	336	22	known	know	VBN
cord-000372-wzwpyvll	336	23	that	that	IN
cord-000372-wzwpyvll	336	24	preribosomal	preribosomal	JJ
cord-000372-wzwpyvll	336	25	subunits	subunit	NNS
cord-000372-wzwpyvll	336	26	are	be	VBP
cord-000372-wzwpyvll	336	27	exported	export	VBN
cord-000372-wzwpyvll	336	28	by	by	IN
cord-000372-wzwpyvll	336	29	separate	separate	JJ
cord-000372-wzwpyvll	336	30	routes	route	NNS
cord-000372-wzwpyvll	336	31	that	that	WDT
cord-000372-wzwpyvll	336	32	involve	involve	VBP
cord-000372-wzwpyvll	336	33	CRM1	CRM1	NNP
cord-000372-wzwpyvll	336	34	and	and	CC
cord-000372-wzwpyvll	336	35	RanGTP	RanGTP	NNS
cord-000372-wzwpyvll	336	36	,	,	,
cord-000372-wzwpyvll	336	37	nowadays	nowadays	RB
cord-000372-wzwpyvll	336	38	the	the	DT
cord-000372-wzwpyvll	336	39	exact	exact	JJ
cord-000372-wzwpyvll	336	40	mechanism	mechanism	NN
cord-000372-wzwpyvll	336	41	followed	follow	VBN
cord-000372-wzwpyvll	336	42	by	by	IN
cord-000372-wzwpyvll	336	43	40S	40s	CD
cord-000372-wzwpyvll	336	44	preribosomal	preribosomal	NNP
cord-000372-wzwpyvll	336	45	subunits	subunit	NNS
cord-000372-wzwpyvll	336	46	to	to	TO
cord-000372-wzwpyvll	336	47	leave	leave	VB
cord-000372-wzwpyvll	336	48	the	the	DT
cord-000372-wzwpyvll	336	49	nucleus	nucleus	NN
cord-000372-wzwpyvll	336	50	remains	remain	VBZ
cord-000372-wzwpyvll	336	51	unclear	unclear	JJ
cord-000372-wzwpyvll	336	52	[	[	-LRB-
cord-000372-wzwpyvll	336	53	163	163	CD
cord-000372-wzwpyvll	336	54	]	]	-RRB-
cord-000372-wzwpyvll	336	55	.	.	.
cord-000372-wzwpyvll	337	1	However	however	RB
cord-000372-wzwpyvll	337	2	,	,	,
cord-000372-wzwpyvll	337	3	60S	60s	CD
cord-000372-wzwpyvll	337	4	preribosomal	preribosomal	NNP
cord-000372-wzwpyvll	337	5	subunit	subunit	NN
cord-000372-wzwpyvll	337	6	relies	rely	VBZ
cord-000372-wzwpyvll	337	7	on	on	IN
cord-000372-wzwpyvll	337	8	Nmd3	Nmd3	NNP
cord-000372-wzwpyvll	337	9	adaptor	adaptor	NN
cord-000372-wzwpyvll	337	10	,	,	,
cord-000372-wzwpyvll	337	11	which	which	WDT
cord-000372-wzwpyvll	337	12	mediates	mediate	VBZ
cord-000372-wzwpyvll	337	13	the	the	DT
cord-000372-wzwpyvll	337	14	interaction	interaction	NN
cord-000372-wzwpyvll	337	15	with	with	IN
cord-000372-wzwpyvll	337	16	CRM1	CRM1	NNP
cord-000372-wzwpyvll	337	17	[	[	-LRB-
cord-000372-wzwpyvll	337	18	179	179	CD
cord-000372-wzwpyvll	337	19	,	,	,
cord-000372-wzwpyvll	337	20	180	180	CD
cord-000372-wzwpyvll	337	21	]	]	-RRB-
cord-000372-wzwpyvll	337	22	.	.	.
cord-000372-wzwpyvll	338	1	The	the	DT
cord-000372-wzwpyvll	338	2	release	release	NN
cord-000372-wzwpyvll	338	3	of	of	IN
cord-000372-wzwpyvll	338	4	the	the	DT
cord-000372-wzwpyvll	338	5	60S	60s	CD
cord-000372-wzwpyvll	338	6	preribosomal	preribosomal	JJ
cord-000372-wzwpyvll	338	7	subunit	subunit	NN
cord-000372-wzwpyvll	338	8	requires	require	VBZ
cord-000372-wzwpyvll	338	9	two	two	CD
cord-000372-wzwpyvll	338	10	GTPase	GTPase	NNP
cord-000372-wzwpyvll	338	11	steps	step	NNS
cord-000372-wzwpyvll	338	12	:	:	:
cord-000372-wzwpyvll	338	13	(	(	-LRB-
cord-000372-wzwpyvll	338	14	i	i	NN
cord-000372-wzwpyvll	338	15	)	)	-RRB-
cord-000372-wzwpyvll	339	1	the	the	DT
cord-000372-wzwpyvll	339	2	hydrolysis	hydrolysis	NN
cord-000372-wzwpyvll	339	3	of	of	IN
cord-000372-wzwpyvll	339	4	the	the	DT
cord-000372-wzwpyvll	339	5	Ran	Ran	NNP
cord-000372-wzwpyvll	339	6	-	-	HYPH
cord-000372-wzwpyvll	339	7	associated	associate	VBN
cord-000372-wzwpyvll	339	8	GTP	GTP	NNP
cord-000372-wzwpyvll	339	9	induces	induce	VBZ
cord-000372-wzwpyvll	339	10	the	the	DT
cord-000372-wzwpyvll	339	11	liberation	liberation	NN
cord-000372-wzwpyvll	339	12	of	of	IN
cord-000372-wzwpyvll	339	13	CRM1	CRM1	NNP
cord-000372-wzwpyvll	339	14	;	;	:
cord-000372-wzwpyvll	339	15	and	and	CC
cord-000372-wzwpyvll	339	16	(	(	-LRB-
cord-000372-wzwpyvll	339	17	ii	ii	NN
cord-000372-wzwpyvll	339	18	)	)	-RRB-
cord-000372-wzwpyvll	340	1	the	the	DT
cord-000372-wzwpyvll	340	2	hydrolysis	hydrolysis	NN
cord-000372-wzwpyvll	340	3	of	of	IN
cord-000372-wzwpyvll	340	4	GTP	GTP	NNP
cord-000372-wzwpyvll	340	5	mediated	mediate	VBN
cord-000372-wzwpyvll	340	6	by	by	IN
cord-000372-wzwpyvll	340	7	the	the	DT
cord-000372-wzwpyvll	340	8	cytoplasmic	cytoplasmic	JJ
cord-000372-wzwpyvll	340	9	GTPase	GTPase	NNP
cord-000372-wzwpyvll	340	10	Lsg1	Lsg1	NNP
cord-000372-wzwpyvll	340	11	,	,	,
cord-000372-wzwpyvll	340	12	which	which	WDT
cord-000372-wzwpyvll	340	13	induces	induce	VBZ
cord-000372-wzwpyvll	340	14	the	the	DT
cord-000372-wzwpyvll	340	15	release	release	NN
cord-000372-wzwpyvll	340	16	of	of	IN
cord-000372-wzwpyvll	340	17	Nmd3	Nmd3	NNP
cord-000372-wzwpyvll	340	18	[	[	-LRB-
cord-000372-wzwpyvll	340	19	181	181	CD
cord-000372-wzwpyvll	340	20	]	]	-RRB-
cord-000372-wzwpyvll	340	21	.	.	.
cord-000372-wzwpyvll	341	1	Finally	finally	RB
cord-000372-wzwpyvll	341	2	,	,	,
cord-000372-wzwpyvll	341	3	mRNAs	mrnas	PRP
cord-000372-wzwpyvll	341	4	compose	compose	VB
cord-000372-wzwpyvll	341	5	the	the	DT
cord-000372-wzwpyvll	341	6	most	most	RBS
cord-000372-wzwpyvll	341	7	heterogeneous	heterogeneous	JJ
cord-000372-wzwpyvll	341	8	group	group	NN
cord-000372-wzwpyvll	341	9	of	of	IN
cord-000372-wzwpyvll	341	10	RNAs	rna	NNS
cord-000372-wzwpyvll	341	11	,	,	,
cord-000372-wzwpyvll	341	12	varying	vary	VBG
cord-000372-wzwpyvll	341	13	in	in	IN
cord-000372-wzwpyvll	341	14	length	length	NN
cord-000372-wzwpyvll	341	15	and	and	CC
cord-000372-wzwpyvll	341	16	structure	structure	NN
cord-000372-wzwpyvll	341	17	.	.	.
cord-000372-wzwpyvll	342	1	Thus	thus	RB
cord-000372-wzwpyvll	342	2	,	,	,
cord-000372-wzwpyvll	342	3	different	different	JJ
cord-000372-wzwpyvll	342	4	export	export	NN
cord-000372-wzwpyvll	342	5	factors	factor	NNS
cord-000372-wzwpyvll	342	6	and	and	CC
cord-000372-wzwpyvll	342	7	adaptor	adaptor	NN
cord-000372-wzwpyvll	342	8	proteins	protein	NNS
cord-000372-wzwpyvll	342	9	associate	associate	VBP
cord-000372-wzwpyvll	342	10	with	with	IN
cord-000372-wzwpyvll	342	11	each	each	DT
cord-000372-wzwpyvll	342	12	subpopulation	subpopulation	NN
cord-000372-wzwpyvll	342	13	of	of	IN
cord-000372-wzwpyvll	342	14	mRNAs	mrnas	CD
cord-000372-wzwpyvll	342	15	[	[	-LRB-
cord-000372-wzwpyvll	342	16	163	163	CD
cord-000372-wzwpyvll	342	17	]	]	-RRB-
cord-000372-wzwpyvll	342	18	.	.	.
cord-000372-wzwpyvll	343	1	mRNAs	mRNAs	NNPS
cord-000372-wzwpyvll	343	2	are	be	VBP
cord-000372-wzwpyvll	343	3	transcribed	transcribe	VBN
cord-000372-wzwpyvll	343	4	by	by	IN
cord-000372-wzwpyvll	343	5	PolII	polii	NN
cord-000372-wzwpyvll	343	6	,	,	,
cord-000372-wzwpyvll	343	7	and	and	CC
cord-000372-wzwpyvll	343	8	,	,	,
cord-000372-wzwpyvll	343	9	concomitantly	concomitantly	RB
cord-000372-wzwpyvll	343	10	with	with	IN
cord-000372-wzwpyvll	343	11	this	this	DT
cord-000372-wzwpyvll	343	12	process	process	NN
cord-000372-wzwpyvll	343	13	,	,	,
cord-000372-wzwpyvll	343	14	a	a	DT
cord-000372-wzwpyvll	343	15	number	number	NN
cord-000372-wzwpyvll	343	16	of	of	IN
cord-000372-wzwpyvll	343	17	RNA	rna	NN
cord-000372-wzwpyvll	343	18	-	-	HYPH
cord-000372-wzwpyvll	343	19	binding	bind	VBG
cord-000372-wzwpyvll	343	20	proteins	protein	NNS
cord-000372-wzwpyvll	343	21	assemble	assemble	VBP
cord-000372-wzwpyvll	343	22	with	with	IN
cord-000372-wzwpyvll	343	23	them	-PRON-	PRP
cord-000372-wzwpyvll	343	24	.	.	.
cord-000372-wzwpyvll	344	1	These	these	DT
cord-000372-wzwpyvll	344	2	RNAbinding	rnabinding	NN
cord-000372-wzwpyvll	344	3	proteins	protein	NNS
cord-000372-wzwpyvll	344	4	exert	exert	VBP
cord-000372-wzwpyvll	344	5	different	different	JJ
cord-000372-wzwpyvll	344	6	modifications	modification	NNS
cord-000372-wzwpyvll	344	7	in	in	IN
cord-000372-wzwpyvll	344	8	immature	immature	JJ
cord-000372-wzwpyvll	344	9	mRNAs	mrna	NNS
cord-000372-wzwpyvll	344	10	such	such	JJ
cord-000372-wzwpyvll	344	11	as	as	IN
cord-000372-wzwpyvll	344	12	polyadenylation	polyadenylation	NN
cord-000372-wzwpyvll	344	13	,	,	,
cord-000372-wzwpyvll	344	14	splicing	splicing	NN
cord-000372-wzwpyvll	344	15	and	and	CC
cord-000372-wzwpyvll	344	16	capping	capping	NN
cord-000372-wzwpyvll	344	17	.	.	.
cord-000372-wzwpyvll	345	1	In	in	IN
cord-000372-wzwpyvll	345	2	addition	addition	NN
cord-000372-wzwpyvll	345	3	,	,	,
cord-000372-wzwpyvll	345	4	export	export	NN
cord-000372-wzwpyvll	345	5	factors	factor	NNS
cord-000372-wzwpyvll	345	6	and	and	CC
cord-000372-wzwpyvll	345	7	adaptor	adaptor	NN
cord-000372-wzwpyvll	345	8	proteins	protein	NNS
cord-000372-wzwpyvll	345	9	are	be	VBP
cord-000372-wzwpyvll	345	10	also	also	RB
cord-000372-wzwpyvll	345	11	recruited	recruit	VBN
cord-000372-wzwpyvll	345	12	to	to	IN
cord-000372-wzwpyvll	345	13	nascent	nascent	JJ
cord-000372-wzwpyvll	345	14	pre	pre	NN
cord-000372-wzwpyvll	345	15	-	-	NNS
cord-000372-wzwpyvll	345	16	mRNAs	mrna	NNS
cord-000372-wzwpyvll	345	17	,	,	,
cord-000372-wzwpyvll	345	18	playing	play	VBG
cord-000372-wzwpyvll	345	19	a	a	DT
cord-000372-wzwpyvll	345	20	further	further	JJ
cord-000372-wzwpyvll	345	21	function	function	NN
cord-000372-wzwpyvll	345	22	in	in	IN
cord-000372-wzwpyvll	345	23	nuclear	nuclear	JJ
cord-000372-wzwpyvll	345	24	export	export	NN
cord-000372-wzwpyvll	345	25	.	.	.
cord-000372-wzwpyvll	346	1	TREX	TREX	NNP
cord-000372-wzwpyvll	346	2	(	(	-LRB-
cord-000372-wzwpyvll	346	3	transcription	transcription	NN
cord-000372-wzwpyvll	346	4	-	-	HYPH
cord-000372-wzwpyvll	346	5	coupled	couple	VBN
cord-000372-wzwpyvll	346	6	export	export	NN
cord-000372-wzwpyvll	347	1	)	)	-RRB-
cord-000372-wzwpyvll	347	2	complex	complex	NNP
cord-000372-wzwpyvll	347	3	is	be	VBZ
cord-000372-wzwpyvll	347	4	recruited	recruit	VBN
cord-000372-wzwpyvll	347	5	to	to	IN
cord-000372-wzwpyvll	347	6	the	the	DT
cord-000372-wzwpyvll	347	7	5	5	CD
cord-000372-wzwpyvll	347	8	end	end	NN
cord-000372-wzwpyvll	347	9	of	of	IN
cord-000372-wzwpyvll	347	10	nascent	nascent	JJ
cord-000372-wzwpyvll	347	11	pre	pre	NN
cord-000372-wzwpyvll	347	12	-	-	NNS
cord-000372-wzwpyvll	347	13	mRNAs	mrna	NNS
cord-000372-wzwpyvll	347	14	in	in	IN
cord-000372-wzwpyvll	347	15	a	a	DT
cord-000372-wzwpyvll	347	16	splicing	splicing	NN
cord-000372-wzwpyvll	347	17	-	-	HYPH
cord-000372-wzwpyvll	347	18	dependent	dependent	JJ
cord-000372-wzwpyvll	347	19	manner	manner	NN
cord-000372-wzwpyvll	347	20	by	by	IN
cord-000372-wzwpyvll	347	21	means	mean	NNS
cord-000372-wzwpyvll	347	22	of	of	IN
cord-000372-wzwpyvll	347	23	the	the	DT
cord-000372-wzwpyvll	347	24	interaction	interaction	NN
cord-000372-wzwpyvll	347	25	of	of	IN
cord-000372-wzwpyvll	347	26	one	one	CD
cord-000372-wzwpyvll	347	27	of	of	IN
cord-000372-wzwpyvll	347	28	its	-PRON-	PRP$
cord-000372-wzwpyvll	347	29	components	component	NNS
cord-000372-wzwpyvll	347	30	,	,	,
cord-000372-wzwpyvll	347	31	namely	namely	RB
cord-000372-wzwpyvll	347	32	ALY	ALY	NNP
cord-000372-wzwpyvll	347	33	/	/	SYM
cord-000372-wzwpyvll	347	34	REF	REF	NNP
cord-000372-wzwpyvll	347	35	,	,	,
cord-000372-wzwpyvll	347	36	with	with	IN
cord-000372-wzwpyvll	347	37	the	the	DT
cord-000372-wzwpyvll	347	38	subunit	subunit	NN
cord-000372-wzwpyvll	347	39	of	of	IN
cord-000372-wzwpyvll	347	40	the	the	DT
cord-000372-wzwpyvll	347	41	nuclear	nuclear	JJ
cord-000372-wzwpyvll	347	42	cap	cap	NN
cord-000372-wzwpyvll	347	43	-	-	HYPH
cord-000372-wzwpyvll	347	44	binding	bind	VBG
cord-000372-wzwpyvll	347	45	complex	complex	NN
cord-000372-wzwpyvll	347	46	CBP80	CBP80	.
cord-000372-wzwpyvll	347	47	[	[	-LRB-
cord-000372-wzwpyvll	347	48	182	182	CD
cord-000372-wzwpyvll	347	49	]	]	-RRB-
cord-000372-wzwpyvll	347	50	.	.	.
cord-000372-wzwpyvll	348	1	The	the	DT
cord-000372-wzwpyvll	348	2	TREX	TREX	NNP
cord-000372-wzwpyvll	348	3	complex	complex	NN
cord-000372-wzwpyvll	348	4	also	also	RB
cord-000372-wzwpyvll	348	5	recruits	recruit	VBZ
cord-000372-wzwpyvll	348	6	the	the	DT
cord-000372-wzwpyvll	348	7	conserved	conserve	VBN
cord-000372-wzwpyvll	348	8	RNA	RNA	NNP
cord-000372-wzwpyvll	348	9	-	-	HYPH
cord-000372-wzwpyvll	348	10	helicase	helicase	NN
cord-000372-wzwpyvll	348	11	UAP56	UAP56	.
cord-000372-wzwpyvll	349	1	that	that	DT
cord-000372-wzwpyvll	349	2	is	be	VBZ
cord-000372-wzwpyvll	349	3	important	important	JJ
cord-000372-wzwpyvll	349	4	for	for	IN
cord-000372-wzwpyvll	349	5	mRNP	mRNP	VBG
cord-000372-wzwpyvll	349	6	biogenesis	biogenesis	NN
cord-000372-wzwpyvll	349	7	[	[	-LRB-
cord-000372-wzwpyvll	349	8	183	183	CD
cord-000372-wzwpyvll	349	9	]	]	-RRB-
cord-000372-wzwpyvll	349	10	.	.	.
cord-000372-wzwpyvll	350	1	TAP	TAP	NNP
cord-000372-wzwpyvll	350	2	-	-	HYPH
cord-000372-wzwpyvll	350	3	p15	p15	NN
cord-000372-wzwpyvll	350	4	,	,	,
cord-000372-wzwpyvll	350	5	(	(	-LRB-
cord-000372-wzwpyvll	350	6	also	also	RB
cord-000372-wzwpyvll	350	7	known	know	VBN
cord-000372-wzwpyvll	350	8	as	as	IN
cord-000372-wzwpyvll	350	9	NXF1-NXT1	NXF1-NXT1	NNP
cord-000372-wzwpyvll	350	10	)	)	-RRB-
cord-000372-wzwpyvll	350	11	directly	directly	RB
cord-000372-wzwpyvll	350	12	binds	bind	VBZ
cord-000372-wzwpyvll	350	13	the	the	DT
cord-000372-wzwpyvll	350	14	mRNA	mrna	NN
cord-000372-wzwpyvll	350	15	immediately	immediately	RB
cord-000372-wzwpyvll	350	16	after	after	IN
cord-000372-wzwpyvll	350	17	splicing	splice	VBG
cord-000372-wzwpyvll	350	18	and	and	CC
cord-000372-wzwpyvll	350	19	actively	actively	RB
cord-000372-wzwpyvll	350	20	participates	participate	VBZ
cord-000372-wzwpyvll	350	21	in	in	IN
cord-000372-wzwpyvll	350	22	mRNA	mRNA	NNP
cord-000372-wzwpyvll	350	23	export	export	NN
cord-000372-wzwpyvll	350	24	.	.	.
cord-000372-wzwpyvll	351	1	ALY	ALY	NNP
cord-000372-wzwpyvll	351	2	/	/	SYM
cord-000372-wzwpyvll	351	3	REF	REF	NNP
cord-000372-wzwpyvll	351	4	,	,	,
cord-000372-wzwpyvll	351	5	TAP	TAP	NNP
cord-000372-wzwpyvll	351	6	-	-	HYPH
cord-000372-wzwpyvll	351	7	p15	p15	NN
cord-000372-wzwpyvll	351	8	and	and	CC
cord-000372-wzwpyvll	351	9	UAP56	UAP56	NNP
cord-000372-wzwpyvll	351	10	associate	associate	NN
cord-000372-wzwpyvll	351	11	with	with	IN
cord-000372-wzwpyvll	351	12	exon	exon	NN
cord-000372-wzwpyvll	351	13	junction	junction	NN
cord-000372-wzwpyvll	351	14	complexes	complex	NNS
cord-000372-wzwpyvll	351	15	(	(	-LRB-
cord-000372-wzwpyvll	351	16	EJC	EJC	NNP
cord-000372-wzwpyvll	351	17	)	)	-RRB-
cord-000372-wzwpyvll	351	18	,	,	,
cord-000372-wzwpyvll	351	19	which	which	WDT
cord-000372-wzwpyvll	351	20	are	be	VBP
cord-000372-wzwpyvll	351	21	deposited	deposit	VBN
cord-000372-wzwpyvll	351	22	in	in	IN
cord-000372-wzwpyvll	351	23	a	a	DT
cord-000372-wzwpyvll	351	24	splicingdependent	splicingdependent	NN
cord-000372-wzwpyvll	351	25	manner	manner	NN
cord-000372-wzwpyvll	351	26	at	at	IN
cord-000372-wzwpyvll	351	27	20	20	CD
cord-000372-wzwpyvll	351	28	-	-	SYM
cord-000372-wzwpyvll	351	29	24	24	CD
cord-000372-wzwpyvll	351	30	nt	nt	RB
cord-000372-wzwpyvll	351	31	of	of	IN
cord-000372-wzwpyvll	351	32	every	every	DT
cord-000372-wzwpyvll	351	33	exon	exon	NN
cord-000372-wzwpyvll	351	34	-	-	HYPH
cord-000372-wzwpyvll	351	35	exon	exon	NN
cord-000372-wzwpyvll	351	36	junction	junction	NN
cord-000372-wzwpyvll	351	37	[	[	-LRB-
cord-000372-wzwpyvll	351	38	184	184	CD
cord-000372-wzwpyvll	351	39	,	,	,
cord-000372-wzwpyvll	351	40	185	185	CD
cord-000372-wzwpyvll	351	41	]	]	-RRB-
cord-000372-wzwpyvll	351	42	.	.	.
cord-000372-wzwpyvll	352	1	This	this	DT
cord-000372-wzwpyvll	352	2	interaction	interaction	NN
cord-000372-wzwpyvll	352	3	network	network	NN
cord-000372-wzwpyvll	352	4	makes	make	VBZ
cord-000372-wzwpyvll	352	5	spliced	splice	VBN
cord-000372-wzwpyvll	352	6	mRNAs	mrnas	RP
cord-000372-wzwpyvll	352	7	more	more	RBR
cord-000372-wzwpyvll	352	8	susceptible	susceptible	JJ
cord-000372-wzwpyvll	352	9	to	to	IN
cord-000372-wzwpyvll	352	10	export	export	NN
cord-000372-wzwpyvll	352	11	and	and	CC
cord-000372-wzwpyvll	352	12	couple	couple	NN
cord-000372-wzwpyvll	352	13	splicing	splicing	NN
cord-000372-wzwpyvll	352	14	and	and	CC
cord-000372-wzwpyvll	352	15	mRNAtrafficking	mrnatrafficking	NN
cord-000372-wzwpyvll	352	16	.	.	.
cord-000372-wzwpyvll	353	1	In	in	IN
cord-000372-wzwpyvll	353	2	fact	fact	NN
cord-000372-wzwpyvll	353	3	,	,	,
cord-000372-wzwpyvll	353	4	unspliced	unspliced	JJ
cord-000372-wzwpyvll	353	5	mRNAs	mRNAs	NNPS
cord-000372-wzwpyvll	353	6	are	be	VBP
cord-000372-wzwpyvll	353	7	exported	export	VBN
cord-000372-wzwpyvll	353	8	by	by	IN
cord-000372-wzwpyvll	353	9	an	an	DT
cord-000372-wzwpyvll	353	10	alternative	alternative	NN
cord-000372-wzwpyvll	353	11	and	and	CC
cord-000372-wzwpyvll	353	12	less	less	RBR
cord-000372-wzwpyvll	353	13	efficient	efficient	JJ
cord-000372-wzwpyvll	353	14	pathway	pathway	NN
cord-000372-wzwpyvll	353	15	that	that	WDT
cord-000372-wzwpyvll	353	16	involves	involve	VBZ
cord-000372-wzwpyvll	353	17	CRM1	CRM1	NNP
cord-000372-wzwpyvll	353	18	and	and	CC
cord-000372-wzwpyvll	353	19	RanGTP	RanGTP	NNS
cord-000372-wzwpyvll	353	20	.	.	.
cord-000372-wzwpyvll	354	1	This	this	DT
cord-000372-wzwpyvll	354	2	alternative	alternative	JJ
cord-000372-wzwpyvll	354	3	route	route	NN
cord-000372-wzwpyvll	354	4	is	be	VBZ
cord-000372-wzwpyvll	354	5	also	also	RB
cord-000372-wzwpyvll	354	6	followed	follow	VBN
cord-000372-wzwpyvll	354	7	by	by	IN
cord-000372-wzwpyvll	354	8	mRNAs	mrna	NNS
cord-000372-wzwpyvll	354	9	encoding	encode	VBG
cord-000372-wzwpyvll	354	10	some	some	DT
cord-000372-wzwpyvll	354	11	protoncogenes	protoncogene	NNS
cord-000372-wzwpyvll	354	12	and	and	CC
cord-000372-wzwpyvll	354	13	cytokines	cytokine	NNS
cord-000372-wzwpyvll	354	14	[	[	-LRB-
cord-000372-wzwpyvll	354	15	186	186	CD
cord-000372-wzwpyvll	354	16	,	,	,
cord-000372-wzwpyvll	354	17	187	187	CD
cord-000372-wzwpyvll	354	18	]	]	-RRB-
cord-000372-wzwpyvll	354	19	.	.	.
cord-000372-wzwpyvll	355	1	It	-PRON-	PRP
cord-000372-wzwpyvll	355	2	is	be	VBZ
cord-000372-wzwpyvll	355	3	important	important	JJ
cord-000372-wzwpyvll	355	4	to	to	TO
cord-000372-wzwpyvll	355	5	mention	mention	VB
cord-000372-wzwpyvll	355	6	that	that	IN
cord-000372-wzwpyvll	355	7	although	although	IN
cord-000372-wzwpyvll	355	8	mRNA	mRNA	NNP
cord-000372-wzwpyvll	355	9	can	can	MD
cord-000372-wzwpyvll	355	10	follow	follow	VB
cord-000372-wzwpyvll	355	11	different	different	JJ
cord-000372-wzwpyvll	355	12	nuclear	nuclear	JJ
cord-000372-wzwpyvll	355	13	export	export	NN
cord-000372-wzwpyvll	355	14	pathways	pathway	NNS
cord-000372-wzwpyvll	355	15	,	,	,
cord-000372-wzwpyvll	355	16	in	in	IN
cord-000372-wzwpyvll	355	17	all	all	DT
cord-000372-wzwpyvll	355	18	cases	case	NNS
cord-000372-wzwpyvll	355	19	the	the	DT
cord-000372-wzwpyvll	355	20	interaction	interaction	NN
cord-000372-wzwpyvll	355	21	of	of	IN
cord-000372-wzwpyvll	355	22	export	export	NN
cord-000372-wzwpyvll	355	23	receptors	receptor	NNS
cord-000372-wzwpyvll	355	24	with	with	IN
cord-000372-wzwpyvll	355	25	nucleoporins	nucleoporin	NNS
cord-000372-wzwpyvll	355	26	plays	play	VBZ
cord-000372-wzwpyvll	355	27	an	an	DT
cord-000372-wzwpyvll	355	28	essential	essential	JJ
cord-000372-wzwpyvll	355	29	role	role	NN
cord-000372-wzwpyvll	355	30	in	in	IN
cord-000372-wzwpyvll	355	31	the	the	DT
cord-000372-wzwpyvll	355	32	transport	transport	NN
cord-000372-wzwpyvll	355	33	of	of	IN
cord-000372-wzwpyvll	355	34	the	the	DT
cord-000372-wzwpyvll	355	35	mRNPs	mRNPs	NNPS
cord-000372-wzwpyvll	355	36	throughout	throughout	IN
cord-000372-wzwpyvll	355	37	the	the	DT
cord-000372-wzwpyvll	355	38	NPC	NPC	NNP
cord-000372-wzwpyvll	355	39	[	[	-LRB-
cord-000372-wzwpyvll	355	40	170	170	CD
cord-000372-wzwpyvll	355	41	]	]	-RRB-
cord-000372-wzwpyvll	355	42	.	.	.
cord-000372-wzwpyvll	356	1	Protein	Protein	NNP
cord-000372-wzwpyvll	356	2	and	and	CC
cord-000372-wzwpyvll	356	3	RNA	RNA	NNP
cord-000372-wzwpyvll	356	4	Trafficking	trafficking	NN
cord-000372-wzwpyvll	356	5	by	by	IN
cord-000372-wzwpyvll	356	6	PV	PV	NNP
cord-000372-wzwpyvll	356	7	2A	2a	NN
cord-000372-wzwpyvll	356	8	pro	pro	JJ
cord-000372-wzwpyvll	356	9	.	.	.
cord-000372-wzwpyvll	357	1	PV	pv	NN
cord-000372-wzwpyvll	357	2	infection	infection	NN
cord-000372-wzwpyvll	357	3	strongly	strongly	RB
cord-000372-wzwpyvll	357	4	impacts	impact	VBZ
cord-000372-wzwpyvll	357	5	on	on	IN
cord-000372-wzwpyvll	357	6	hostcell	hostcell	NNP
cord-000372-wzwpyvll	357	7	protein	protein	NN
cord-000372-wzwpyvll	357	8	localization	localization	NN
cord-000372-wzwpyvll	357	9	,	,	,
cord-000372-wzwpyvll	357	10	giving	give	VBG
cord-000372-wzwpyvll	357	11	rise	rise	NN
cord-000372-wzwpyvll	357	12	to	to	IN
cord-000372-wzwpyvll	357	13	an	an	DT
cord-000372-wzwpyvll	357	14	unusual	unusual	JJ
cord-000372-wzwpyvll	357	15	cytoplasmic	cytoplasmic	JJ
cord-000372-wzwpyvll	357	16	distribution	distribution	NN
cord-000372-wzwpyvll	357	17	of	of	IN
cord-000372-wzwpyvll	357	18	nuclear	nuclear	JJ
cord-000372-wzwpyvll	357	19	proteins	protein	NNS
cord-000372-wzwpyvll	357	20	[	[	-LRB-
cord-000372-wzwpyvll	357	21	188	188	CD
cord-000372-wzwpyvll	357	22	]	]	-RRB-
cord-000372-wzwpyvll	357	23	.	.	.
cord-000372-wzwpyvll	358	1	This	this	DT
cord-000372-wzwpyvll	358	2	particular	particular	JJ
cord-000372-wzwpyvll	358	3	effect	effect	NN
cord-000372-wzwpyvll	358	4	has	have	VBZ
cord-000372-wzwpyvll	358	5	been	be	VBN
cord-000372-wzwpyvll	358	6	characterized	characterize	VBN
cord-000372-wzwpyvll	358	7	by	by	IN
cord-000372-wzwpyvll	358	8	different	different	JJ
cord-000372-wzwpyvll	358	9	laboratories	laboratory	NNS
cord-000372-wzwpyvll	358	10	for	for	IN
cord-000372-wzwpyvll	358	11	a	a	DT
cord-000372-wzwpyvll	358	12	number	number	NN
cord-000372-wzwpyvll	358	13	of	of	IN
cord-000372-wzwpyvll	358	14	nuclear	nuclear	JJ
cord-000372-wzwpyvll	358	15	factors	factor	NNS
cord-000372-wzwpyvll	358	16	involved	involve	VBN
cord-000372-wzwpyvll	358	17	in	in	IN
cord-000372-wzwpyvll	358	18	several	several	JJ
cord-000372-wzwpyvll	358	19	cellular	cellular	JJ
cord-000372-wzwpyvll	358	20	processes	process	NNS
cord-000372-wzwpyvll	358	21	and	and	CC
cord-000372-wzwpyvll	358	22	containing	contain	VBG
cord-000372-wzwpyvll	358	23	different	different	JJ
cord-000372-wzwpyvll	358	24	types	type	NNS
cord-000372-wzwpyvll	358	25	of	of	IN
cord-000372-wzwpyvll	358	26	NLSs	nls	NNS
cord-000372-wzwpyvll	358	27	[	[	-LRB-
cord-000372-wzwpyvll	358	28	189	189	CD
cord-000372-wzwpyvll	358	29	]	]	-RRB-
cord-000372-wzwpyvll	358	30	.	.	.
cord-000372-wzwpyvll	359	1	Nevertheless	nevertheless	RB
cord-000372-wzwpyvll	359	2	,	,	,
cord-000372-wzwpyvll	359	3	not	not	RB
cord-000372-wzwpyvll	359	4	all	all	DT
cord-000372-wzwpyvll	359	5	nuclear	nuclear	JJ
cord-000372-wzwpyvll	359	6	proteins	protein	NNS
cord-000372-wzwpyvll	359	7	are	be	VBP
cord-000372-wzwpyvll	359	8	re	re	VBN
cord-000372-wzwpyvll	359	9	-	-	VBN
cord-000372-wzwpyvll	359	10	localized	localize	VBN
cord-000372-wzwpyvll	359	11	after	after	IN
cord-000372-wzwpyvll	359	12	PV	pv	NN
cord-000372-wzwpyvll	359	13	infection	infection	NN
cord-000372-wzwpyvll	359	14	,	,	,
cord-000372-wzwpyvll	359	15	evidencing	evidence	VBG
cord-000372-wzwpyvll	359	16	the	the	DT
cord-000372-wzwpyvll	359	17	presence	presence	NN
cord-000372-wzwpyvll	359	18	of	of	IN
cord-000372-wzwpyvll	359	19	a	a	DT
cord-000372-wzwpyvll	359	20	viral	viral	JJ
cord-000372-wzwpyvll	359	21	-	-	HYPH
cord-000372-wzwpyvll	359	22	specific	specific	JJ
cord-000372-wzwpyvll	359	23	mechanism	mechanism	NN
cord-000372-wzwpyvll	359	24	affecting	affect	VBG
cord-000372-wzwpyvll	359	25	protein	protein	NN
cord-000372-wzwpyvll	359	26	subcellular	subcellular	JJ
cord-000372-wzwpyvll	359	27	distribution	distribution	NN
cord-000372-wzwpyvll	359	28	[	[	-LRB-
cord-000372-wzwpyvll	359	29	188	188	CD
cord-000372-wzwpyvll	359	30	]	]	-RRB-
cord-000372-wzwpyvll	359	31	.	.	.
cord-000372-wzwpyvll	360	1	Gustin	Gustin	NNP
cord-000372-wzwpyvll	360	2	and	and	CC
cord-000372-wzwpyvll	360	3	colleagues	colleague	NNS
cord-000372-wzwpyvll	360	4	proposed	propose	VBD
cord-000372-wzwpyvll	360	5	the	the	DT
cord-000372-wzwpyvll	360	6	inhibition	inhibition	NN
cord-000372-wzwpyvll	360	7	of	of	IN
cord-000372-wzwpyvll	360	8	nuclear	nuclear	JJ
cord-000372-wzwpyvll	360	9	protein	protein	NN
cord-000372-wzwpyvll	360	10	import	import	NN
cord-000372-wzwpyvll	360	11	machinery	machinery	NN
cord-000372-wzwpyvll	360	12	as	as	IN
cord-000372-wzwpyvll	360	13	the	the	DT
cord-000372-wzwpyvll	360	14	cause	cause	NN
cord-000372-wzwpyvll	360	15	of	of	IN
cord-000372-wzwpyvll	360	16	the	the	DT
cord-000372-wzwpyvll	360	17	cytoplasmic	cytoplasmic	JJ
cord-000372-wzwpyvll	360	18	accumulation	accumulation	NN
cord-000372-wzwpyvll	360	19	of	of	IN
cord-000372-wzwpyvll	360	20	nuclear	nuclear	JJ
cord-000372-wzwpyvll	360	21	proteins	protein	NNS
cord-000372-wzwpyvll	360	22	in	in	IN
cord-000372-wzwpyvll	360	23	PV	pv	NN
cord-000372-wzwpyvll	360	24	-	-	HYPH
cord-000372-wzwpyvll	360	25	infected	infect	VBN
cord-000372-wzwpyvll	360	26	cells	cell	NNS
cord-000372-wzwpyvll	360	27	(	(	-LRB-
cord-000372-wzwpyvll	360	28	Figure	figure	NN
cord-000372-wzwpyvll	360	29	4	4	CD
cord-000372-wzwpyvll	360	30	)	)	-RRB-
cord-000372-wzwpyvll	360	31	.	.	.
cord-000372-wzwpyvll	361	1	They	-PRON-	PRP
cord-000372-wzwpyvll	361	2	demonstrated	demonstrate	VBD
cord-000372-wzwpyvll	361	3	that	that	IN
cord-000372-wzwpyvll	361	4	PV	PV	NNP
cord-000372-wzwpyvll	361	5	impairs	impair	VBZ
cord-000372-wzwpyvll	361	6	protein	protein	NN
cord-000372-wzwpyvll	361	7	trafficking	traffic	VBG
cord-000372-wzwpyvll	361	8	across	across	IN
cord-000372-wzwpyvll	361	9	the	the	DT
cord-000372-wzwpyvll	361	10	NPC	NPC	NNP
cord-000372-wzwpyvll	361	11	by	by	IN
cord-000372-wzwpyvll	361	12	expressing	express	VBG
cord-000372-wzwpyvll	361	13	GFP	GFP	NNP
cord-000372-wzwpyvll	361	14	proteins	protein	NNS
cord-000372-wzwpyvll	361	15	encoding	encode	VBG
cord-000372-wzwpyvll	361	16	classical	classical	JJ
cord-000372-wzwpyvll	361	17	or	or	CC
cord-000372-wzwpyvll	361	18	transporting	transport	VBG
cord-000372-wzwpyvll	361	19	NLSs	nls	NNS
cord-000372-wzwpyvll	361	20	in	in	IN
cord-000372-wzwpyvll	361	21	mock	mock	NN
cord-000372-wzwpyvll	361	22	and	and	CC
cord-000372-wzwpyvll	361	23	infected	infected	JJ
cord-000372-wzwpyvll	361	24	cultured	cultured	JJ
cord-000372-wzwpyvll	361	25	cells	cell	NNS
cord-000372-wzwpyvll	361	26	[	[	-LRB-
cord-000372-wzwpyvll	361	27	15	15	CD
cord-000372-wzwpyvll	361	28	,	,	,
cord-000372-wzwpyvll	361	29	16	16	CD
cord-000372-wzwpyvll	361	30	,	,	,
cord-000372-wzwpyvll	361	31	159	159	CD
cord-000372-wzwpyvll	361	32	]	]	-RRB-
cord-000372-wzwpyvll	361	33	.	.	.
cord-000372-wzwpyvll	362	1	These	these	DT
cord-000372-wzwpyvll	362	2	recombinant	recombinant	JJ
cord-000372-wzwpyvll	362	3	proteins	protein	NNS
cord-000372-wzwpyvll	362	4	accumulate	accumulate	VBP
cord-000372-wzwpyvll	362	5	in	in	IN
cord-000372-wzwpyvll	362	6	the	the	DT
cord-000372-wzwpyvll	362	7	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	362	8	after	after	IN
cord-000372-wzwpyvll	362	9	PV	pv	NN
cord-000372-wzwpyvll	362	10	infection	infection	NN
cord-000372-wzwpyvll	362	11	,	,	,
cord-000372-wzwpyvll	362	12	being	be	VBG
cord-000372-wzwpyvll	362	13	almost	almost	RB
cord-000372-wzwpyvll	362	14	completely	completely	RB
cord-000372-wzwpyvll	362	15	depleted	deplete	VBN
cord-000372-wzwpyvll	362	16	from	from	IN
cord-000372-wzwpyvll	362	17	the	the	DT
cord-000372-wzwpyvll	362	18	nucleus	nucleus	NN
cord-000372-wzwpyvll	362	19	.	.	.
cord-000372-wzwpyvll	363	1	Nevertheless	nevertheless	RB
cord-000372-wzwpyvll	363	2	,	,	,
cord-000372-wzwpyvll	363	3	PV	PV	NNP
cord-000372-wzwpyvll	363	4	does	do	VBZ
cord-000372-wzwpyvll	363	5	not	not	RB
cord-000372-wzwpyvll	363	6	affect	affect	VB
cord-000372-wzwpyvll	363	7	GFP	GFP	NNP
cord-000372-wzwpyvll	363	8	distribution	distribution	NN
cord-000372-wzwpyvll	363	9	when	when	WRB
cord-000372-wzwpyvll	363	10	the	the	DT
cord-000372-wzwpyvll	363	11	NLS	NLS	NNP
cord-000372-wzwpyvll	363	12	is	be	VBZ
cord-000372-wzwpyvll	363	13	mutated	mutate	VBN
cord-000372-wzwpyvll	363	14	or	or	CC
cord-000372-wzwpyvll	363	15	deleted	delete	VBN
cord-000372-wzwpyvll	363	16	,	,	,
cord-000372-wzwpyvll	363	17	since	since	IN
cord-000372-wzwpyvll	363	18	the	the	DT
cord-000372-wzwpyvll	363	19	small	small	JJ
cord-000372-wzwpyvll	363	20	size	size	NN
cord-000372-wzwpyvll	363	21	of	of	IN
cord-000372-wzwpyvll	363	22	GFP	GFP	NNP
cord-000372-wzwpyvll	363	23	allows	allow	VBZ
cord-000372-wzwpyvll	363	24	its	-PRON-	PRP$
cord-000372-wzwpyvll	363	25	inefficient	inefficient	JJ
cord-000372-wzwpyvll	363	26	efflux	efflux	NN
cord-000372-wzwpyvll	363	27	throughout	throughout	IN
cord-000372-wzwpyvll	363	28	the	the	DT
cord-000372-wzwpyvll	363	29	NPC	NPC	NNP
cord-000372-wzwpyvll	363	30	[	[	-LRB-
cord-000372-wzwpyvll	363	31	15	15	CD
cord-000372-wzwpyvll	363	32	]	]	-RRB-
cord-000372-wzwpyvll	363	33	.	.	.
cord-000372-wzwpyvll	364	1	Interestingly	interestingly	RB
cord-000372-wzwpyvll	364	2	,	,	,
cord-000372-wzwpyvll	364	3	cell	cell	NN
cord-000372-wzwpyvll	364	4	-	-	HYPH
cord-000372-wzwpyvll	364	5	free	free	JJ
cord-000372-wzwpyvll	364	6	nuclear	nuclear	JJ
cord-000372-wzwpyvll	364	7	import	import	NN
cord-000372-wzwpyvll	364	8	assays	assay	NNS
cord-000372-wzwpyvll	364	9	demonstrated	demonstrate	VBD
cord-000372-wzwpyvll	364	10	that	that	IN
cord-000372-wzwpyvll	364	11	NLS	nls	NN
cord-000372-wzwpyvll	364	12	-	-	HYPH
cord-000372-wzwpyvll	364	13	containing	contain	VBG
cord-000372-wzwpyvll	364	14	GFP	GFP	NNP
cord-000372-wzwpyvll	364	15	is	be	VBZ
cord-000372-wzwpyvll	364	16	unable	unable	JJ
cord-000372-wzwpyvll	364	17	to	to	TO
cord-000372-wzwpyvll	364	18	traverse	traverse	VB
cord-000372-wzwpyvll	364	19	the	the	DT
cord-000372-wzwpyvll	364	20	NPC	NPC	NNP
cord-000372-wzwpyvll	364	21	when	when	WRB
cord-000372-wzwpyvll	364	22	cells	cell	NNS
cord-000372-wzwpyvll	364	23	are	be	VBP
cord-000372-wzwpyvll	364	24	previously	previously	RB
cord-000372-wzwpyvll	364	25	infected	infect	VBN
cord-000372-wzwpyvll	364	26	with	with	IN
cord-000372-wzwpyvll	364	27	PV	PV	NNP
cord-000372-wzwpyvll	364	28	[	[	-LRB-
cord-000372-wzwpyvll	364	29	15	15	CD
cord-000372-wzwpyvll	364	30	]	]	-RRB-
cord-000372-wzwpyvll	364	31	.	.	.
cord-000372-wzwpyvll	365	1	In	in	IN
cord-000372-wzwpyvll	365	2	agreement	agreement	NN
cord-000372-wzwpyvll	365	3	with	with	IN
cord-000372-wzwpyvll	365	4	these	these	DT
cord-000372-wzwpyvll	365	5	findings	finding	NNS
cord-000372-wzwpyvll	365	6	,	,	,
cord-000372-wzwpyvll	365	7	shuttling	shuttle	VBG
cord-000372-wzwpyvll	365	8	endogenous	endogenous	JJ
cord-000372-wzwpyvll	365	9	proteins	protein	NNS
cord-000372-wzwpyvll	365	10	,	,	,
cord-000372-wzwpyvll	365	11	such	such	JJ
cord-000372-wzwpyvll	365	12	as	as	IN
cord-000372-wzwpyvll	365	13	heterogeneous	heterogeneous	JJ
cord-000372-wzwpyvll	365	14	nuclear	nuclear	JJ
cord-000372-wzwpyvll	365	15	ribonucleoprotein	ribonucleoprotein	NN
cord-000372-wzwpyvll	365	16	(	(	-LRB-
cord-000372-wzwpyvll	365	17	hnRNP	hnrnp	NN
cord-000372-wzwpyvll	365	18	)	)	-RRB-
cord-000372-wzwpyvll	365	19	A1	a1	NN
cord-000372-wzwpyvll	365	20	and	and	CC
cord-000372-wzwpyvll	365	21	hnRNP	hnrnp	NN
cord-000372-wzwpyvll	366	1	K	K	NNP
cord-000372-wzwpyvll	366	2	,	,	,
cord-000372-wzwpyvll	366	3	are	be	VBP
cord-000372-wzwpyvll	366	4	detected	detect	VBN
cord-000372-wzwpyvll	366	5	in	in	IN
cord-000372-wzwpyvll	366	6	the	the	DT
cord-000372-wzwpyvll	366	7	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	366	8	of	of	IN
cord-000372-wzwpyvll	366	9	infected	infected	JJ
cord-000372-wzwpyvll	366	10	cells	cell	NNS
cord-000372-wzwpyvll	366	11	from	from	IN
cord-000372-wzwpyvll	366	12	3	3	CD
cord-000372-wzwpyvll	366	13	hpi	hpi	NNS
cord-000372-wzwpyvll	366	14	but	but	CC
cord-000372-wzwpyvll	366	15	are	be	VBP
cord-000372-wzwpyvll	366	16	undetectable	undetectable	JJ
cord-000372-wzwpyvll	366	17	in	in	IN
cord-000372-wzwpyvll	366	18	the	the	DT
cord-000372-wzwpyvll	366	19	nucleus	nucleus	NN
cord-000372-wzwpyvll	366	20	at	at	IN
cord-000372-wzwpyvll	366	21	4.5	4.5	CD
cord-000372-wzwpyvll	366	22	hpi	hpi	NNP
cord-000372-wzwpyvll	366	23	.	.	.
cord-000372-wzwpyvll	367	1	However	however	RB
cord-000372-wzwpyvll	367	2	,	,	,
cord-000372-wzwpyvll	367	3	cytoplasmic	cytoplasmic	JJ
cord-000372-wzwpyvll	367	4	accumulation	accumulation	NN
cord-000372-wzwpyvll	367	5	of	of	IN
cord-000372-wzwpyvll	367	6	nuclear	nuclear	JJ
cord-000372-wzwpyvll	367	7	resident	resident	NN
cord-000372-wzwpyvll	367	8	proteins	protein	NNS
cord-000372-wzwpyvll	367	9	such	such	JJ
cord-000372-wzwpyvll	367	10	as	as	IN
cord-000372-wzwpyvll	367	11	hnRNP	hnRNP	NNP
cord-000372-wzwpyvll	368	1	C	C	NNP
cord-000372-wzwpyvll	368	2	requires	require	VBZ
cord-000372-wzwpyvll	368	3	longer	long	JJR
cord-000372-wzwpyvll	368	4	times	time	NNS
cord-000372-wzwpyvll	368	5	of	of	IN
cord-000372-wzwpyvll	368	6	infection	infection	NN
cord-000372-wzwpyvll	368	7	[	[	-LRB-
cord-000372-wzwpyvll	368	8	15	15	CD
cord-000372-wzwpyvll	368	9	]	]	-RRB-
cord-000372-wzwpyvll	368	10	.	.	.
cord-000372-wzwpyvll	369	1	These	these	DT
cord-000372-wzwpyvll	369	2	findings	finding	NNS
cord-000372-wzwpyvll	369	3	support	support	VBP
cord-000372-wzwpyvll	369	4	the	the	DT
cord-000372-wzwpyvll	369	5	idea	idea	NN
cord-000372-wzwpyvll	369	6	that	that	IN
cord-000372-wzwpyvll	369	7	the	the	DT
cord-000372-wzwpyvll	369	8	distribution	distribution	NN
cord-000372-wzwpyvll	369	9	of	of	IN
cord-000372-wzwpyvll	369	10	a	a	DT
cord-000372-wzwpyvll	369	11	protein	protein	NN
cord-000372-wzwpyvll	369	12	that	that	WDT
cord-000372-wzwpyvll	369	13	shuttles	shuttle	NNS
cord-000372-wzwpyvll	369	14	between	between	IN
cord-000372-wzwpyvll	369	15	nucleus	nucleus	NN
cord-000372-wzwpyvll	369	16	and	and	CC
cord-000372-wzwpyvll	369	17	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	369	18	may	may	MD
cord-000372-wzwpyvll	369	19	be	be	VB
cord-000372-wzwpyvll	369	20	strongly	strongly	RB
cord-000372-wzwpyvll	369	21	altered	alter	VBN
cord-000372-wzwpyvll	369	22	by	by	IN
cord-000372-wzwpyvll	369	23	the	the	DT
cord-000372-wzwpyvll	369	24	disruption	disruption	NN
cord-000372-wzwpyvll	369	25	of	of	IN
cord-000372-wzwpyvll	369	26	protein	protein	NN
cord-000372-wzwpyvll	369	27	trafficking	trafficking	NN
cord-000372-wzwpyvll	369	28	pathways	pathway	NNS
cord-000372-wzwpyvll	369	29	,	,	,
cord-000372-wzwpyvll	369	30	as	as	IN
cord-000372-wzwpyvll	369	31	compared	compare	VBN
cord-000372-wzwpyvll	369	32	to	to	IN
cord-000372-wzwpyvll	369	33	nuclear	nuclear	JJ
cord-000372-wzwpyvll	369	34	resident	resident	NN
cord-000372-wzwpyvll	369	35	proteins	protein	NNS
cord-000372-wzwpyvll	369	36	.	.	.
cord-000372-wzwpyvll	370	1	However	however	RB
cord-000372-wzwpyvll	370	2	,	,	,
cord-000372-wzwpyvll	370	3	not	not	RB
cord-000372-wzwpyvll	370	4	all	all	PDT
cord-000372-wzwpyvll	370	5	the	the	DT
cord-000372-wzwpyvll	370	6	nuclear	nuclear	JJ
cord-000372-wzwpyvll	370	7	factors	factor	NNS
cord-000372-wzwpyvll	370	8	are	be	VBP
cord-000372-wzwpyvll	370	9	redistributed	redistribute	VBN
cord-000372-wzwpyvll	370	10	to	to	IN
cord-000372-wzwpyvll	370	11	the	the	DT
cord-000372-wzwpyvll	370	12	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	370	13	of	of	IN
cord-000372-wzwpyvll	370	14	PV	pv	NN
cord-000372-wzwpyvll	370	15	-	-	HYPH
cord-000372-wzwpyvll	370	16	infected	infect	VBN
cord-000372-wzwpyvll	370	17	cells	cell	NNS
cord-000372-wzwpyvll	370	18	.	.	.
cord-000372-wzwpyvll	371	1	This	this	DT
cord-000372-wzwpyvll	371	2	is	be	VBZ
cord-000372-wzwpyvll	371	3	the	the	DT
cord-000372-wzwpyvll	371	4	case	case	NN
cord-000372-wzwpyvll	371	5	for	for	IN
cord-000372-wzwpyvll	371	6	SC35	SC35	NNP
cord-000372-wzwpyvll	371	7	(	(	-LRB-
cord-000372-wzwpyvll	371	8	a	a	DT
cord-000372-wzwpyvll	371	9	serine	serine	NN
cord-000372-wzwpyvll	371	10	/	/	SYM
cord-000372-wzwpyvll	371	11	arginine	arginine	NN
cord-000372-wzwpyvll	371	12	-	-	HYPH
cord-000372-wzwpyvll	371	13	rich	rich	JJ
cord-000372-wzwpyvll	371	14	splicing	splicing	NN
cord-000372-wzwpyvll	371	15	factor	factor	NN
cord-000372-wzwpyvll	371	16	)	)	-RRB-
cord-000372-wzwpyvll	371	17	,	,	,
cord-000372-wzwpyvll	371	18	fibrillarin	fibrillarin	NNP
cord-000372-wzwpyvll	371	19	or	or	CC
cord-000372-wzwpyvll	371	20	TATA	TATA	NNP
cord-000372-wzwpyvll	371	21	-	-	HYPH
cord-000372-wzwpyvll	371	22	binding	bind	VBG
cord-000372-wzwpyvll	371	23	protein	protein	NN
cord-000372-wzwpyvll	371	24	(	(	-LRB-
cord-000372-wzwpyvll	371	25	TBP	TBP	NNP
cord-000372-wzwpyvll	371	26	)	)	-RRB-
cord-000372-wzwpyvll	371	27	,	,	,
cord-000372-wzwpyvll	371	28	which	which	WDT
cord-000372-wzwpyvll	371	29	remain	remain	VBP
cord-000372-wzwpyvll	371	30	in	in	IN
cord-000372-wzwpyvll	371	31	the	the	DT
cord-000372-wzwpyvll	371	32	nucleus	nucleus	NN
cord-000372-wzwpyvll	371	33	for	for	IN
cord-000372-wzwpyvll	371	34	the	the	DT
cord-000372-wzwpyvll	371	35	duration	duration	NN
cord-000372-wzwpyvll	371	36	of	of	IN
cord-000372-wzwpyvll	371	37	infection	infection	NN
cord-000372-wzwpyvll	371	38	.	.	.
cord-000372-wzwpyvll	372	1	The	the	DT
cord-000372-wzwpyvll	372	2	different	different	JJ
cord-000372-wzwpyvll	372	3	behaviour	behaviour	NN
cord-000372-wzwpyvll	372	4	of	of	IN
cord-000372-wzwpyvll	372	5	these	these	DT
cord-000372-wzwpyvll	372	6	groups	group	NNS
cord-000372-wzwpyvll	372	7	of	of	IN
cord-000372-wzwpyvll	372	8	proteins	protein	NNS
cord-000372-wzwpyvll	372	9	could	could	MD
cord-000372-wzwpyvll	372	10	arise	arise	VB
cord-000372-wzwpyvll	372	11	as	as	IN
cord-000372-wzwpyvll	372	12	a	a	DT
cord-000372-wzwpyvll	372	13	consequence	consequence	NN
cord-000372-wzwpyvll	372	14	of	of	IN
cord-000372-wzwpyvll	372	15	different	different	JJ
cord-000372-wzwpyvll	372	16	turnover	turnover	NN
cord-000372-wzwpyvll	372	17	;	;	:
cord-000372-wzwpyvll	372	18	thus	thus	RB
cord-000372-wzwpyvll	372	19	,	,	,
cord-000372-wzwpyvll	372	20	the	the	DT
cord-000372-wzwpyvll	372	21	distribution	distribution	NN
cord-000372-wzwpyvll	372	22	of	of	IN
cord-000372-wzwpyvll	372	23	highly	highly	RB
cord-000372-wzwpyvll	372	24	stable	stable	JJ
cord-000372-wzwpyvll	372	25	nuclear	nuclear	JJ
cord-000372-wzwpyvll	372	26	proteins	protein	NNS
cord-000372-wzwpyvll	372	27	might	may	MD
cord-000372-wzwpyvll	372	28	be	be	VB
cord-000372-wzwpyvll	372	29	less	less	RBR
cord-000372-wzwpyvll	372	30	affected	affect	VBN
cord-000372-wzwpyvll	372	31	by	by	IN
cord-000372-wzwpyvll	372	32	the	the	DT
cord-000372-wzwpyvll	372	33	inhibition	inhibition	NN
cord-000372-wzwpyvll	372	34	of	of	IN
cord-000372-wzwpyvll	372	35	protein	protein	NN
cord-000372-wzwpyvll	372	36	nuclear	nuclear	JJ
cord-000372-wzwpyvll	372	37	import	import	NN
cord-000372-wzwpyvll	372	38	than	than	IN
cord-000372-wzwpyvll	372	39	those	those	DT
cord-000372-wzwpyvll	372	40	proteins	protein	NNS
cord-000372-wzwpyvll	372	41	with	with	IN
cord-000372-wzwpyvll	372	42	low	low	JJ
cord-000372-wzwpyvll	372	43	stability	stability	NN
cord-000372-wzwpyvll	372	44	.	.	.
cord-000372-wzwpyvll	373	1	Alternatively	alternatively	RB
cord-000372-wzwpyvll	373	2	,	,	,
cord-000372-wzwpyvll	373	3	PV	PV	NNP
cord-000372-wzwpyvll	373	4	might	may	MD
cord-000372-wzwpyvll	373	5	not	not	RB
cord-000372-wzwpyvll	373	6	impair	impair	VB
cord-000372-wzwpyvll	373	7	all	all	DT
cord-000372-wzwpyvll	373	8	protein	protein	NN
cord-000372-wzwpyvll	373	9	import	import	NN
cord-000372-wzwpyvll	373	10	pathways	pathway	NNS
cord-000372-wzwpyvll	373	11	,	,	,
cord-000372-wzwpyvll	373	12	and	and	CC
cord-000372-wzwpyvll	373	13	some	some	DT
cord-000372-wzwpyvll	373	14	might	may	MD
cord-000372-wzwpyvll	373	15	remain	remain	VB
cord-000372-wzwpyvll	373	16	operative	operative	JJ
cord-000372-wzwpyvll	373	17	,	,	,
cord-000372-wzwpyvll	373	18	thereby	thereby	RB
cord-000372-wzwpyvll	373	19	allowing	allow	VBG
cord-000372-wzwpyvll	373	20	the	the	DT
cord-000372-wzwpyvll	373	21	nuclear	nuclear	JJ
cord-000372-wzwpyvll	373	22	import	import	NN
cord-000372-wzwpyvll	373	23	of	of	IN
cord-000372-wzwpyvll	373	24	several	several	JJ
cord-000372-wzwpyvll	373	25	families	family	NNS
cord-000372-wzwpyvll	373	26	of	of	IN
cord-000372-wzwpyvll	373	27	nuclear	nuclear	JJ
cord-000372-wzwpyvll	373	28	proteins	protein	NNS
cord-000372-wzwpyvll	373	29	.	.	.
cord-000372-wzwpyvll	374	1	Interestingly	interestingly	RB
cord-000372-wzwpyvll	374	2	,	,	,
cord-000372-wzwpyvll	374	3	some	some	DT
cord-000372-wzwpyvll	374	4	nuclear	nuclear	JJ
cord-000372-wzwpyvll	374	5	factors	factor	NNS
cord-000372-wzwpyvll	374	6	such	such	JJ
cord-000372-wzwpyvll	374	7	as	as	IN
cord-000372-wzwpyvll	374	8	La	La	NNP
cord-000372-wzwpyvll	374	9	antigen	antigen	NNP
cord-000372-wzwpyvll	374	10	[	[	-LRB-
cord-000372-wzwpyvll	374	11	190	190	CD
cord-000372-wzwpyvll	374	12	]	]	-RRB-
cord-000372-wzwpyvll	374	13	,	,	,
cord-000372-wzwpyvll	374	14	PTB	PTB	NNP
cord-000372-wzwpyvll	374	15	[	[	-LRB-
cord-000372-wzwpyvll	374	16	191	191	CD
cord-000372-wzwpyvll	374	17	]	]	-RRB-
cord-000372-wzwpyvll	374	18	,	,	,
cord-000372-wzwpyvll	374	19	Sam68	Sam68	NNP
cord-000372-wzwpyvll	374	20	[	[	-LRB-
cord-000372-wzwpyvll	374	21	192	192	CD
cord-000372-wzwpyvll	374	22	]	]	-RRB-
cord-000372-wzwpyvll	374	23	,	,	,
cord-000372-wzwpyvll	374	24	or	or	CC
cord-000372-wzwpyvll	374	25	nucleolin	nucleolin	NNP
cord-000372-wzwpyvll	374	26	[	[	-LRB-
cord-000372-wzwpyvll	374	27	188	188	CD
cord-000372-wzwpyvll	374	28	]	]	-RRB-
cord-000372-wzwpyvll	374	29	have	have	VBP
cord-000372-wzwpyvll	374	30	been	be	VBN
cord-000372-wzwpyvll	374	31	shown	show	VBN
cord-000372-wzwpyvll	374	32	to	to	TO
cord-000372-wzwpyvll	374	33	interact	interact	VB
cord-000372-wzwpyvll	374	34	with	with	IN
cord-000372-wzwpyvll	374	35	PV	PV	NNP
cord-000372-wzwpyvll	374	36	RNA	RNA	NNP
cord-000372-wzwpyvll	374	37	or	or	CC
cord-000372-wzwpyvll	374	38	viral	viral	JJ
cord-000372-wzwpyvll	374	39	proteins	protein	NNS
cord-000372-wzwpyvll	374	40	.	.	.
cord-000372-wzwpyvll	375	1	These	these	DT
cord-000372-wzwpyvll	375	2	proteins	protein	NNS
cord-000372-wzwpyvll	375	3	accumulate	accumulate	VBP
cord-000372-wzwpyvll	375	4	in	in	IN
cord-000372-wzwpyvll	375	5	the	the	DT
cord-000372-wzwpyvll	375	6	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	375	7	of	of	IN
cord-000372-wzwpyvll	375	8	PV	pv	NN
cord-000372-wzwpyvll	375	9	-	-	HYPH
cord-000372-wzwpyvll	375	10	infected	infect	VBN
cord-000372-wzwpyvll	375	11	cells	cell	NNS
cord-000372-wzwpyvll	375	12	and	and	CC
cord-000372-wzwpyvll	375	13	,	,	,
cord-000372-wzwpyvll	375	14	consequently	consequently	RB
cord-000372-wzwpyvll	375	15	,	,	,
cord-000372-wzwpyvll	375	16	their	-PRON-	PRP$
cord-000372-wzwpyvll	375	17	availability	availability	NN
cord-000372-wzwpyvll	375	18	for	for	IN
cord-000372-wzwpyvll	375	19	viral	viral	JJ
cord-000372-wzwpyvll	375	20	replication	replication	NN
cord-000372-wzwpyvll	375	21	is	be	VBZ
cord-000372-wzwpyvll	375	22	increased	increase	VBN
cord-000372-wzwpyvll	375	23	[	[	-LRB-
cord-000372-wzwpyvll	375	24	188	188	CD
cord-000372-wzwpyvll	375	25	,	,	,
cord-000372-wzwpyvll	375	26	[	[	-LRB-
cord-000372-wzwpyvll	375	27	193	193	CD
cord-000372-wzwpyvll	375	28	]	]	-RRB-
cord-000372-wzwpyvll	375	29	[	[	-LRB-
cord-000372-wzwpyvll	375	30	194	194	CD
cord-000372-wzwpyvll	375	31	]	]	-RRB-
cord-000372-wzwpyvll	375	32	[	[	-LRB-
cord-000372-wzwpyvll	375	33	195	195	CD
cord-000372-wzwpyvll	375	34	]	]	-RRB-
cord-000372-wzwpyvll	375	35	.	.	.
cord-000372-wzwpyvll	376	1	Cytoplasmic	cytoplasmic	JJ
cord-000372-wzwpyvll	376	2	accumulation	accumulation	NN
cord-000372-wzwpyvll	376	3	of	of	IN
cord-000372-wzwpyvll	376	4	nuclear	nuclear	JJ
cord-000372-wzwpyvll	376	5	factors	factor	NNS
cord-000372-wzwpyvll	376	6	might	may	MD
cord-000372-wzwpyvll	376	7	be	be	VB
cord-000372-wzwpyvll	376	8	produced	produce	VBN
cord-000372-wzwpyvll	376	9	mostly	mostly	RB
cord-000372-wzwpyvll	376	10	by	by	IN
cord-000372-wzwpyvll	376	11	the	the	DT
cord-000372-wzwpyvll	376	12	blockade	blockade	NN
cord-000372-wzwpyvll	376	13	of	of	IN
cord-000372-wzwpyvll	376	14	nuclear	nuclear	JJ
cord-000372-wzwpyvll	376	15	-	-	HYPH
cord-000372-wzwpyvll	376	16	cytoplasmic	cytoplasmic	JJ
cord-000372-wzwpyvll	376	17	trafficking	trafficking	NN
cord-000372-wzwpyvll	376	18	.	.	.
cord-000372-wzwpyvll	377	1	However	however	RB
cord-000372-wzwpyvll	377	2	,	,	,
cord-000372-wzwpyvll	377	3	loss	loss	NN
cord-000372-wzwpyvll	377	4	of	of	IN
cord-000372-wzwpyvll	377	5	the	the	DT
cord-000372-wzwpyvll	377	6	NLS	NLS	NNP
cord-000372-wzwpyvll	377	7	after	after	IN
cord-000372-wzwpyvll	377	8	the	the	DT
cord-000372-wzwpyvll	377	9	cleavage	cleavage	NN
cord-000372-wzwpyvll	377	10	of	of	IN
cord-000372-wzwpyvll	377	11	PTB	PTB	NNP
cord-000372-wzwpyvll	377	12	and	and	CC
cord-000372-wzwpyvll	377	13	La	La	NNP
cord-000372-wzwpyvll	377	14	proteins	protein	NNS
cord-000372-wzwpyvll	377	15	by	by	IN
cord-000372-wzwpyvll	377	16	PV	PV	NNP
cord-000372-wzwpyvll	377	17	3C	3c	NN
cord-000372-wzwpyvll	377	18	pro	pro	NN
cord-000372-wzwpyvll	377	19	may	may	MD
cord-000372-wzwpyvll	377	20	also	also	RB
cord-000372-wzwpyvll	377	21	contribute	contribute	VB
cord-000372-wzwpyvll	377	22	to	to	IN
cord-000372-wzwpyvll	377	23	the	the	DT
cord-000372-wzwpyvll	377	24	subcellular	subcellular	JJ
cord-000372-wzwpyvll	377	25	relocalization	relocalization	NN
cord-000372-wzwpyvll	377	26	of	of	IN
cord-000372-wzwpyvll	377	27	those	those	DT
cord-000372-wzwpyvll	377	28	proteins	protein	NNS
cord-000372-wzwpyvll	377	29	in	in	IN
cord-000372-wzwpyvll	377	30	PV	pv	NN
cord-000372-wzwpyvll	377	31	-	-	HYPH
cord-000372-wzwpyvll	377	32	infected	infect	VBN
cord-000372-wzwpyvll	377	33	cells	cell	NNS
cord-000372-wzwpyvll	377	34	[	[	-LRB-
cord-000372-wzwpyvll	377	35	193	193	CD
cord-000372-wzwpyvll	377	36	,	,	,
cord-000372-wzwpyvll	377	37	195	195	CD
cord-000372-wzwpyvll	377	38	]	]	-RRB-
cord-000372-wzwpyvll	377	39	.	.	.
cord-000372-wzwpyvll	378	1	Redistribution	redistribution	NN
cord-000372-wzwpyvll	378	2	of	of	IN
cord-000372-wzwpyvll	378	3	nuclear	nuclear	JJ
cord-000372-wzwpyvll	378	4	proteins	protein	NNS
cord-000372-wzwpyvll	378	5	as	as	RB
cord-000372-wzwpyvll	378	6	well	well	RB
cord-000372-wzwpyvll	378	7	as	as	IN
cord-000372-wzwpyvll	378	8	impairment	impairment	NN
cord-000372-wzwpyvll	378	9	of	of	IN
cord-000372-wzwpyvll	378	10	cellular	cellular	JJ
cord-000372-wzwpyvll	378	11	import	import	NN
cord-000372-wzwpyvll	378	12	machinery	machinery	NN
cord-000372-wzwpyvll	378	13	was	be	VBD
cord-000372-wzwpyvll	378	14	also	also	RB
cord-000372-wzwpyvll	378	15	observed	observe	VBN
cord-000372-wzwpyvll	378	16	in	in	IN
cord-000372-wzwpyvll	378	17	cells	cell	NNS
cord-000372-wzwpyvll	378	18	infected	infect	VBN
cord-000372-wzwpyvll	378	19	with	with	IN
cord-000372-wzwpyvll	378	20	other	other	JJ
cord-000372-wzwpyvll	378	21	picornaviruses	picornavirus	NNS
cord-000372-wzwpyvll	378	22	such	such	JJ
cord-000372-wzwpyvll	378	23	as	as	IN
cord-000372-wzwpyvll	378	24	HRV	HRV	NNP
cord-000372-wzwpyvll	378	25	[	[	-LRB-
cord-000372-wzwpyvll	378	26	159	159	CD
cord-000372-wzwpyvll	378	27	]	]	-RRB-
cord-000372-wzwpyvll	378	28	or	or	CC
cord-000372-wzwpyvll	378	29	EMCV	EMCV	NNP
cord-000372-wzwpyvll	378	30	[	[	-LRB-
cord-000372-wzwpyvll	378	31	160	160	CD
cord-000372-wzwpyvll	378	32	]	]	-RRB-
cord-000372-wzwpyvll	378	33	.	.	.
cord-000372-wzwpyvll	379	1	These	these	DT
cord-000372-wzwpyvll	379	2	findings	finding	NNS
cord-000372-wzwpyvll	379	3	indicate	indicate	VBP
cord-000372-wzwpyvll	379	4	that	that	IN
cord-000372-wzwpyvll	379	5	most	most	JJS
cord-000372-wzwpyvll	379	6	picornaviruses	picornavirus	NNS
cord-000372-wzwpyvll	379	7	might	may	MD
cord-000372-wzwpyvll	379	8	share	share	VB
cord-000372-wzwpyvll	379	9	similar	similar	JJ
cord-000372-wzwpyvll	379	10	strategies	strategy	NNS
cord-000372-wzwpyvll	379	11	to	to	TO
cord-000372-wzwpyvll	379	12	impair	impair	VB
cord-000372-wzwpyvll	379	13	nuclear	nuclear	JJ
cord-000372-wzwpyvll	379	14	-	-	HYPH
cord-000372-wzwpyvll	379	15	cytoplasmic	cytoplasmic	JJ
cord-000372-wzwpyvll	379	16	trafficking	trafficking	NN
cord-000372-wzwpyvll	379	17	machinery	machinery	NN
cord-000372-wzwpyvll	379	18	.	.	.
cord-000372-wzwpyvll	380	1	An	an	DT
cord-000372-wzwpyvll	380	2	alternative	alternative	JJ
cord-000372-wzwpyvll	380	3	hypothesis	hypothesis	NN
cord-000372-wzwpyvll	380	4	has	have	VBZ
cord-000372-wzwpyvll	380	5	been	be	VBN
cord-000372-wzwpyvll	380	6	proposed	propose	VBN
cord-000372-wzwpyvll	380	7	as	as	IN
cord-000372-wzwpyvll	380	8	the	the	DT
cord-000372-wzwpyvll	380	9	cause	cause	NN
cord-000372-wzwpyvll	380	10	of	of	IN
cord-000372-wzwpyvll	380	11	the	the	DT
cord-000372-wzwpyvll	380	12	redistribution	redistribution	NN
cord-000372-wzwpyvll	380	13	of	of	IN
cord-000372-wzwpyvll	380	14	nuclear	nuclear	JJ
cord-000372-wzwpyvll	380	15	factors	factor	NNS
cord-000372-wzwpyvll	380	16	.	.	.
cord-000372-wzwpyvll	381	1	Belov	Belov	NNP
cord-000372-wzwpyvll	381	2	and	and	CC
cord-000372-wzwpyvll	381	3	colleagues	colleague	NNS
cord-000372-wzwpyvll	381	4	reported	report	VBD
cord-000372-wzwpyvll	381	5	that	that	IN
cord-000372-wzwpyvll	381	6	the	the	DT
cord-000372-wzwpyvll	381	7	nuclear	nuclear	JJ
cord-000372-wzwpyvll	381	8	envelope	envelope	NN
cord-000372-wzwpyvll	381	9	is	be	VBZ
cord-000372-wzwpyvll	381	10	permeabilized	permeabilize	VBN
cord-000372-wzwpyvll	381	11	on	on	IN
cord-000372-wzwpyvll	381	12	PV	pv	NN
cord-000372-wzwpyvll	381	13	infection	infection	NN
cord-000372-wzwpyvll	381	14	,	,	,
cord-000372-wzwpyvll	381	15	allowing	allow	VBG
cord-000372-wzwpyvll	381	16	nuclear	nuclear	JJ
cord-000372-wzwpyvll	381	17	proteins	protein	NNS
cord-000372-wzwpyvll	381	18	to	to	TO
cord-000372-wzwpyvll	381	19	diffuse	diffuse	VB
cord-000372-wzwpyvll	381	20	across	across	IN
cord-000372-wzwpyvll	381	21	the	the	DT
cord-000372-wzwpyvll	381	22	nuclear	nuclear	JJ
cord-000372-wzwpyvll	381	23	membrane	membrane	NN
cord-000372-wzwpyvll	381	24	[	[	-LRB-
cord-000372-wzwpyvll	381	25	196	196	CD
cord-000372-wzwpyvll	381	26	]	]	-RRB-
cord-000372-wzwpyvll	381	27	.	.	.
cord-000372-wzwpyvll	382	1	Indeed	indeed	RB
cord-000372-wzwpyvll	382	2	,	,	,
cord-000372-wzwpyvll	382	3	electron	electron	NN
cord-000372-wzwpyvll	382	4	microscopy	microscopy	NNP
cord-000372-wzwpyvll	382	5	revealed	reveal	VBD
cord-000372-wzwpyvll	382	6	that	that	IN
cord-000372-wzwpyvll	382	7	PV	PV	NNP
cord-000372-wzwpyvll	382	8	2A	2a	NN
cord-000372-wzwpyvll	382	9	pro	pro	NNP
cord-000372-wzwpyvll	382	10	induces	induce	VBZ
cord-000372-wzwpyvll	382	11	severe	severe	JJ
cord-000372-wzwpyvll	382	12	structural	structural	JJ
cord-000372-wzwpyvll	382	13	damage	damage	NN
cord-000372-wzwpyvll	382	14	in	in	IN
cord-000372-wzwpyvll	382	15	NPC	NPC	NNP
cord-000372-wzwpyvll	382	16	[	[	-LRB-
cord-000372-wzwpyvll	382	17	196	196	CD
cord-000372-wzwpyvll	382	18	]	]	-RRB-
cord-000372-wzwpyvll	382	19	.	.	.
cord-000372-wzwpyvll	383	1	However	however	RB
cord-000372-wzwpyvll	383	2	,	,	,
cord-000372-wzwpyvll	383	3	this	this	DT
cord-000372-wzwpyvll	383	4	hypothesis	hypothesis	NN
cord-000372-wzwpyvll	383	5	did	do	VBD
cord-000372-wzwpyvll	383	6	not	not	RB
cord-000372-wzwpyvll	383	7	clarify	clarify	VB
cord-000372-wzwpyvll	383	8	why	why	WRB
cord-000372-wzwpyvll	383	9	other	other	JJ
cord-000372-wzwpyvll	383	10	proteins	protein	NNS
cord-000372-wzwpyvll	383	11	resident	resident	JJ
cord-000372-wzwpyvll	383	12	in	in	IN
cord-000372-wzwpyvll	383	13	the	the	DT
cord-000372-wzwpyvll	383	14	nucleus	nucleus	NN
cord-000372-wzwpyvll	383	15	do	do	VBP
cord-000372-wzwpyvll	383	16	not	not	RB
cord-000372-wzwpyvll	383	17	diffuse	diffuse	VB
cord-000372-wzwpyvll	383	18	to	to	IN
cord-000372-wzwpyvll	383	19	the	the	DT
cord-000372-wzwpyvll	383	20	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	383	21	after	after	IN
cord-000372-wzwpyvll	383	22	PV	pv	NN
cord-000372-wzwpyvll	383	23	infection	infection	NN
cord-000372-wzwpyvll	383	24	.	.	.
cord-000372-wzwpyvll	384	1	Both	both	DT
cord-000372-wzwpyvll	384	2	protein	protein	NN
cord-000372-wzwpyvll	384	3	nuclear	nuclear	JJ
cord-000372-wzwpyvll	384	4	import	import	NN
cord-000372-wzwpyvll	384	5	and	and	CC
cord-000372-wzwpyvll	384	6	permeabilization	permeabilization	NN
cord-000372-wzwpyvll	384	7	of	of	IN
cord-000372-wzwpyvll	384	8	nuclear	nuclear	JJ
cord-000372-wzwpyvll	384	9	envelope	envelope	NN
cord-000372-wzwpyvll	384	10	could	could	MD
cord-000372-wzwpyvll	384	11	be	be	VB
cord-000372-wzwpyvll	384	12	integrated	integrate	VBN
cord-000372-wzwpyvll	384	13	together	together	RB
cord-000372-wzwpyvll	384	14	as	as	IN
cord-000372-wzwpyvll	384	15	sequential	sequential	JJ
cord-000372-wzwpyvll	384	16	steps	step	NNS
cord-000372-wzwpyvll	384	17	in	in	IN
cord-000372-wzwpyvll	384	18	PV	PV	NNP
cord-000372-wzwpyvll	384	19	biological	biological	JJ
cord-000372-wzwpyvll	384	20	cycle	cycle	NN
cord-000372-wzwpyvll	384	21	.	.	.
cord-000372-wzwpyvll	385	1	Protein	protein	NN
cord-000372-wzwpyvll	385	2	import	import	NN
cord-000372-wzwpyvll	385	3	blockade	blockade	NN
cord-000372-wzwpyvll	385	4	is	be	VBZ
cord-000372-wzwpyvll	385	5	detected	detect	VBN
cord-000372-wzwpyvll	385	6	early	early	RB
cord-000372-wzwpyvll	385	7	after	after	IN
cord-000372-wzwpyvll	385	8	infection	infection	NN
cord-000372-wzwpyvll	385	9	[	[	-LRB-
cord-000372-wzwpyvll	385	10	16	16	CD
cord-000372-wzwpyvll	385	11	]	]	-RRB-
cord-000372-wzwpyvll	385	12	,	,	,
cord-000372-wzwpyvll	385	13	correlating	correlate	VBG
cord-000372-wzwpyvll	385	14	with	with	IN
cord-000372-wzwpyvll	385	15	the	the	DT
cord-000372-wzwpyvll	385	16	first	first	JJ
cord-000372-wzwpyvll	385	17	modifications	modification	NNS
cord-000372-wzwpyvll	385	18	in	in	IN
cord-000372-wzwpyvll	385	19	the	the	DT
cord-000372-wzwpyvll	385	20	NPC	NPC	NNP
cord-000372-wzwpyvll	385	21	(	(	-LRB-
cord-000372-wzwpyvll	385	22	see	see	VB
cord-000372-wzwpyvll	385	23	below	below	RB
cord-000372-wzwpyvll	385	24	)	)	-RRB-
cord-000372-wzwpyvll	385	25	.	.	.
cord-000372-wzwpyvll	386	1	However	however	RB
cord-000372-wzwpyvll	386	2	,	,	,
cord-000372-wzwpyvll	386	3	prolonged	prolonged	JJ
cord-000372-wzwpyvll	386	4	expression	expression	NN
cord-000372-wzwpyvll	386	5	of	of	IN
cord-000372-wzwpyvll	386	6	viral	viral	JJ
cord-000372-wzwpyvll	386	7	proteins	protein	NNS
cord-000372-wzwpyvll	386	8	might	may	MD
cord-000372-wzwpyvll	386	9	induce	induce	VB
cord-000372-wzwpyvll	386	10	nuclear	nuclear	JJ
cord-000372-wzwpyvll	386	11	membrane	membrane	NN
cord-000372-wzwpyvll	386	12	leakiness	leakiness	NN
cord-000372-wzwpyvll	386	13	,	,	,
cord-000372-wzwpyvll	386	14	reflected	reflect	VBN
cord-000372-wzwpyvll	386	15	by	by	IN
cord-000372-wzwpyvll	386	16	stronger	strong	JJR
cord-000372-wzwpyvll	386	17	alterations	alteration	NNS
cord-000372-wzwpyvll	386	18	in	in	IN
cord-000372-wzwpyvll	386	19	NPC	NPC	NNP
cord-000372-wzwpyvll	386	20	architecture	architecture	NN
cord-000372-wzwpyvll	386	21	[	[	-LRB-
cord-000372-wzwpyvll	386	22	196	196	CD
cord-000372-wzwpyvll	386	23	]	]	-RRB-
cord-000372-wzwpyvll	386	24	.	.	.
cord-000372-wzwpyvll	387	1	Nevertheless	nevertheless	RB
cord-000372-wzwpyvll	387	2	,	,	,
cord-000372-wzwpyvll	387	3	what	what	WP
cord-000372-wzwpyvll	387	4	might	may	MD
cord-000372-wzwpyvll	387	5	the	the	DT
cord-000372-wzwpyvll	387	6	biological	biological	JJ
cord-000372-wzwpyvll	387	7	relevance	relevance	NN
cord-000372-wzwpyvll	387	8	of	of	IN
cord-000372-wzwpyvll	387	9	these	these	DT
cord-000372-wzwpyvll	387	10	events	event	NNS
cord-000372-wzwpyvll	387	11	be	be	VBP
cord-000372-wzwpyvll	387	12	for	for	IN
cord-000372-wzwpyvll	387	13	a	a	DT
cord-000372-wzwpyvll	387	14	cytoplasmic	cytoplasmic	JJ
cord-000372-wzwpyvll	387	15	virus	virus	NN
cord-000372-wzwpyvll	387	16	?	?	.
cord-000372-wzwpyvll	388	1	The	the	DT
cord-000372-wzwpyvll	388	2	most	most	RBS
cord-000372-wzwpyvll	388	3	evident	evident	JJ
cord-000372-wzwpyvll	388	4	answer	answer	NN
cord-000372-wzwpyvll	388	5	,	,	,
cord-000372-wzwpyvll	388	6	which	which	WDT
cord-000372-wzwpyvll	388	7	was	be	VBD
cord-000372-wzwpyvll	388	8	extensively	extensively	RB
cord-000372-wzwpyvll	388	9	commented	comment	VBN
cord-000372-wzwpyvll	388	10	above	above	RB
cord-000372-wzwpyvll	388	11	,	,	,
cord-000372-wzwpyvll	388	12	is	be	VBZ
cord-000372-wzwpyvll	388	13	that	that	DT
cord-000372-wzwpyvll	388	14	inhibition	inhibition	NN
cord-000372-wzwpyvll	388	15	of	of	IN
cord-000372-wzwpyvll	388	16	nuclear	nuclear	JJ
cord-000372-wzwpyvll	388	17	protein	protein	NN
cord-000372-wzwpyvll	388	18	import	import	NN
cord-000372-wzwpyvll	388	19	and	and	CC
cord-000372-wzwpyvll	388	20	further	further	JJ
cord-000372-wzwpyvll	388	21	nuclear	nuclear	JJ
cord-000372-wzwpyvll	388	22	envelope	envelope	NN
cord-000372-wzwpyvll	388	23	leakiness	leakiness	NN
cord-000372-wzwpyvll	388	24	might	may	MD
cord-000372-wzwpyvll	388	25	increase	increase	VB
cord-000372-wzwpyvll	388	26	the	the	DT
cord-000372-wzwpyvll	388	27	presence	presence	NN
cord-000372-wzwpyvll	388	28	of	of	IN
cord-000372-wzwpyvll	388	29	nuclear	nuclear	JJ
cord-000372-wzwpyvll	388	30	proteins	protein	NNS
cord-000372-wzwpyvll	388	31	in	in	IN
cord-000372-wzwpyvll	388	32	the	the	DT
cord-000372-wzwpyvll	388	33	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	388	34	of	of	IN
cord-000372-wzwpyvll	388	35	infected	infected	JJ
cord-000372-wzwpyvll	388	36	cells	cell	NNS
cord-000372-wzwpyvll	388	37	,	,	,
cord-000372-wzwpyvll	388	38	which	which	WDT
cord-000372-wzwpyvll	388	39	has	have	VBZ
cord-000372-wzwpyvll	388	40	been	be	VBN
cord-000372-wzwpyvll	388	41	proposed	propose	VBN
cord-000372-wzwpyvll	388	42	in	in	IN
cord-000372-wzwpyvll	388	43	some	some	DT
cord-000372-wzwpyvll	388	44	cases	case	NNS
cord-000372-wzwpyvll	388	45	to	to	TO
cord-000372-wzwpyvll	388	46	play	play	VB
cord-000372-wzwpyvll	388	47	a	a	DT
cord-000372-wzwpyvll	388	48	relevant	relevant	JJ
cord-000372-wzwpyvll	388	49	role	role	NN
cord-000372-wzwpyvll	388	50	in	in	IN
cord-000372-wzwpyvll	388	51	PV	pv	NN
cord-000372-wzwpyvll	388	52	replication	replication	NN
cord-000372-wzwpyvll	388	53	.	.	.
cord-000372-wzwpyvll	389	1	In	in	IN
cord-000372-wzwpyvll	389	2	addition	addition	NN
cord-000372-wzwpyvll	389	3	,	,	,
cord-000372-wzwpyvll	389	4	many	many	JJ
cord-000372-wzwpyvll	389	5	transcription	transcription	NN
cord-000372-wzwpyvll	389	6	factors	factor	NNS
cord-000372-wzwpyvll	389	7	are	be	VBP
cord-000372-wzwpyvll	389	8	arrested	arrest	VBN
cord-000372-wzwpyvll	389	9	in	in	IN
cord-000372-wzwpyvll	389	10	the	the	DT
cord-000372-wzwpyvll	389	11	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	389	12	of	of	IN
cord-000372-wzwpyvll	389	13	uninfected	uninfected	JJ
cord-000372-wzwpyvll	389	14	cells	cell	NNS
cord-000372-wzwpyvll	389	15	(	(	-LRB-
cord-000372-wzwpyvll	389	16	e.g.	e.g.	RB
cord-000372-wzwpyvll	389	17	,	,	,
cord-000372-wzwpyvll	389	18	NF	NF	NNP
cord-000372-wzwpyvll	389	19	-	-	HYPH
cord-000372-wzwpyvll	389	20	κB	κB	NNP
cord-000372-wzwpyvll	389	21	,	,	,
cord-000372-wzwpyvll	389	22	IRF7	IRF7	NNP
cord-000372-wzwpyvll	389	23	,	,	,
cord-000372-wzwpyvll	389	24	and	and	CC
cord-000372-wzwpyvll	389	25	IRF3	IRF3	NNP
cord-000372-wzwpyvll	389	26	)	)	-RRB-
cord-000372-wzwpyvll	389	27	,	,	,
cord-000372-wzwpyvll	389	28	but	but	CC
cord-000372-wzwpyvll	389	29	they	-PRON-	PRP
cord-000372-wzwpyvll	389	30	are	be	VBP
cord-000372-wzwpyvll	389	31	immediately	immediately	RB
cord-000372-wzwpyvll	389	32	activated	activate	VBN
cord-000372-wzwpyvll	389	33	and	and	CC
cord-000372-wzwpyvll	389	34	imported	import	VBN
cord-000372-wzwpyvll	389	35	to	to	IN
cord-000372-wzwpyvll	389	36	the	the	DT
cord-000372-wzwpyvll	389	37	nucleus	nucleus	NN
cord-000372-wzwpyvll	389	38	after	after	IN
cord-000372-wzwpyvll	389	39	proinflammatory	proinflammatory	JJ
cord-000372-wzwpyvll	389	40	extracellular	extracellular	JJ
cord-000372-wzwpyvll	389	41	signals	signal	NNS
cord-000372-wzwpyvll	389	42	or	or	CC
cord-000372-wzwpyvll	389	43	on	on	IN
cord-000372-wzwpyvll	389	44	the	the	DT
cord-000372-wzwpyvll	389	45	activation	activation	NN
cord-000372-wzwpyvll	389	46	of	of	IN
cord-000372-wzwpyvll	389	47	intracellular	intracellular	JJ
cord-000372-wzwpyvll	389	48	sensors	sensor	NNS
cord-000372-wzwpyvll	389	49	as	as	IN
cord-000372-wzwpyvll	389	50	a	a	DT
cord-000372-wzwpyvll	389	51	consequence	consequence	NN
cord-000372-wzwpyvll	389	52	of	of	IN
cord-000372-wzwpyvll	389	53	the	the	DT
cord-000372-wzwpyvll	389	54	viral	viral	JJ
cord-000372-wzwpyvll	389	55	replication	replication	NN
cord-000372-wzwpyvll	389	56	.	.	.
cord-000372-wzwpyvll	390	1	Once	once	RB
cord-000372-wzwpyvll	390	2	in	in	IN
cord-000372-wzwpyvll	390	3	the	the	DT
cord-000372-wzwpyvll	390	4	nucleus	nucleus	NN
cord-000372-wzwpyvll	390	5	,	,	,
cord-000372-wzwpyvll	390	6	these	these	DT
cord-000372-wzwpyvll	390	7	factors	factor	NNS
cord-000372-wzwpyvll	390	8	trigger	trigger	VBP
cord-000372-wzwpyvll	390	9	the	the	DT
cord-000372-wzwpyvll	390	10	transcription	transcription	NN
cord-000372-wzwpyvll	390	11	of	of	IN
cord-000372-wzwpyvll	390	12	a	a	DT
cord-000372-wzwpyvll	390	13	set	set	NN
cord-000372-wzwpyvll	390	14	of	of	IN
cord-000372-wzwpyvll	390	15	genes	gene	NNS
cord-000372-wzwpyvll	390	16	involved	involve	VBN
cord-000372-wzwpyvll	390	17	in	in	IN
cord-000372-wzwpyvll	390	18	the	the	DT
cord-000372-wzwpyvll	390	19	antiviral	antiviral	JJ
cord-000372-wzwpyvll	390	20	response	response	NN
cord-000372-wzwpyvll	390	21	[	[	-LRB-
cord-000372-wzwpyvll	390	22	197	197	CD
cord-000372-wzwpyvll	390	23	]	]	-RRB-
cord-000372-wzwpyvll	390	24	.	.	.
cord-000372-wzwpyvll	391	1	Inhibiting	inhibit	VBG
cord-000372-wzwpyvll	391	2	the	the	DT
cord-000372-wzwpyvll	391	3	import	import	NN
cord-000372-wzwpyvll	391	4	of	of	IN
cord-000372-wzwpyvll	391	5	these	these	DT
cord-000372-wzwpyvll	391	6	transcription	transcription	NN
cord-000372-wzwpyvll	391	7	factors	factor	NNS
cord-000372-wzwpyvll	391	8	,	,	,
cord-000372-wzwpyvll	391	9	PV	PV	NNP
cord-000372-wzwpyvll	391	10	might	may	MD
cord-000372-wzwpyvll	391	11	prevent	prevent	VB
cord-000372-wzwpyvll	391	12	or	or	CC
cord-000372-wzwpyvll	391	13	,	,	,
cord-000372-wzwpyvll	391	14	at	at	IN
cord-000372-wzwpyvll	391	15	least	least	JJS
cord-000372-wzwpyvll	391	16	attenuate	attenuate	VB
cord-000372-wzwpyvll	391	17	,	,	,
cord-000372-wzwpyvll	391	18	the	the	DT
cord-000372-wzwpyvll	391	19	establishment	establishment	NN
cord-000372-wzwpyvll	391	20	of	of	IN
cord-000372-wzwpyvll	391	21	a	a	DT
cord-000372-wzwpyvll	391	22	hostile	hostile	JJ
cord-000372-wzwpyvll	391	23	intracellular	intracellular	JJ
cord-000372-wzwpyvll	391	24	environment	environment	NN
cord-000372-wzwpyvll	391	25	.	.	.
cord-000372-wzwpyvll	392	1	Further	further	JJ
cord-000372-wzwpyvll	392	2	effort	effort	NN
cord-000372-wzwpyvll	392	3	will	will	MD
cord-000372-wzwpyvll	392	4	be	be	VB
cord-000372-wzwpyvll	392	5	made	make	VBN
cord-000372-wzwpyvll	392	6	in	in	IN
cord-000372-wzwpyvll	392	7	the	the	DT
cord-000372-wzwpyvll	392	8	future	future	NN
cord-000372-wzwpyvll	392	9	to	to	TO
cord-000372-wzwpyvll	392	10	explore	explore	VB
cord-000372-wzwpyvll	392	11	this	this	DT
cord-000372-wzwpyvll	392	12	attractive	attractive	JJ
cord-000372-wzwpyvll	392	13	hypothesis	hypothesis	NN
cord-000372-wzwpyvll	392	14	.	.	.
cord-000372-wzwpyvll	393	1	Interestingly	interestingly	RB
cord-000372-wzwpyvll	393	2	,	,	,
cord-000372-wzwpyvll	393	3	Nup98	Nup98	NNP
cord-000372-wzwpyvll	393	4	,	,	,
cord-000372-wzwpyvll	393	5	Nup153	nup153	CD
cord-000372-wzwpyvll	393	6	and	and	CC
cord-000372-wzwpyvll	393	7	Nup62	Nup62	NNP
cord-000372-wzwpyvll	393	8	,	,	,
cord-000372-wzwpyvll	393	9	components	component	NNS
cord-000372-wzwpyvll	393	10	of	of	IN
cord-000372-wzwpyvll	393	11	the	the	DT
cord-000372-wzwpyvll	393	12	NPC	NPC	NNP
cord-000372-wzwpyvll	393	13	belonging	belong	VBG
cord-000372-wzwpyvll	393	14	to	to	IN
cord-000372-wzwpyvll	393	15	FG	FG	NNP
cord-000372-wzwpyvll	393	16	Nup	Nup	NNP
cord-000372-wzwpyvll	393	17	family	family	NN
cord-000372-wzwpyvll	393	18	,	,	,
cord-000372-wzwpyvll	393	19	were	be	VBD
cord-000372-wzwpyvll	393	20	found	find	VBN
cord-000372-wzwpyvll	393	21	to	to	TO
cord-000372-wzwpyvll	393	22	be	be	VB
cord-000372-wzwpyvll	393	23	degraded	degrade	VBN
cord-000372-wzwpyvll	393	24	in	in	IN
cord-000372-wzwpyvll	393	25	PV	pv	NN
cord-000372-wzwpyvll	393	26	-	-	:
cord-000372-wzwpyvll	393	27	as	as	RB
cord-000372-wzwpyvll	393	28	well	well	RB
cord-000372-wzwpyvll	393	29	as	as	IN
cord-000372-wzwpyvll	393	30	HRV	HRV	NNP
cord-000372-wzwpyvll	393	31	-	-	HYPH
cord-000372-wzwpyvll	393	32	infected	infect	VBN
cord-000372-wzwpyvll	393	33	cells	cell	NNS
cord-000372-wzwpyvll	393	34	(	(	-LRB-
cord-000372-wzwpyvll	393	35	Figure	figure	NN
cord-000372-wzwpyvll	393	36	4	4	CD
cord-000372-wzwpyvll	393	37	)	)	-RRB-
cord-000372-wzwpyvll	393	38	[	[	-LRB-
cord-000372-wzwpyvll	393	39	15	15	CD
cord-000372-wzwpyvll	393	40	,	,	,
cord-000372-wzwpyvll	393	41	16	16	CD
cord-000372-wzwpyvll	393	42	,	,	,
cord-000372-wzwpyvll	393	43	159	159	CD
cord-000372-wzwpyvll	393	44	]	]	-RRB-
cord-000372-wzwpyvll	393	45	.	.	.
cord-000372-wzwpyvll	394	1	These	these	DT
cord-000372-wzwpyvll	394	2	proteins	protein	NNS
cord-000372-wzwpyvll	394	3	are	be	VBP
cord-000372-wzwpyvll	394	4	essential	essential	JJ
cord-000372-wzwpyvll	394	5	factors	factor	NNS
cord-000372-wzwpyvll	394	6	of	of	IN
cord-000372-wzwpyvll	394	7	the	the	DT
cord-000372-wzwpyvll	394	8	nuclear	nuclear	JJ
cord-000372-wzwpyvll	394	9	-	-	HYPH
cord-000372-wzwpyvll	394	10	cytoplasmic	cytoplasmic	JJ
cord-000372-wzwpyvll	394	11	trafficking	trafficking	NN
cord-000372-wzwpyvll	394	12	machinery	machinery	NN
cord-000372-wzwpyvll	394	13	since	since	IN
cord-000372-wzwpyvll	394	14	their	-PRON-	PRP$
cord-000372-wzwpyvll	394	15	Nterminal	Nterminal	NNP
cord-000372-wzwpyvll	394	16	FG	FG	NNP
cord-000372-wzwpyvll	394	17	-	-	HYPH
cord-000372-wzwpyvll	394	18	rich	rich	JJ
cord-000372-wzwpyvll	394	19	domains	domain	NNS
cord-000372-wzwpyvll	394	20	serve	serve	VBP
cord-000372-wzwpyvll	394	21	as	as	IN
cord-000372-wzwpyvll	394	22	docking	docking	NN
cord-000372-wzwpyvll	394	23	sites	site	NNS
cord-000372-wzwpyvll	394	24	for	for	IN
cord-000372-wzwpyvll	394	25	soluble	soluble	JJ
cord-000372-wzwpyvll	394	26	transport	transport	NN
cord-000372-wzwpyvll	394	27	factors	factor	NNS
cord-000372-wzwpyvll	394	28	[	[	-LRB-
cord-000372-wzwpyvll	394	29	163	163	CD
cord-000372-wzwpyvll	394	30	,	,	,
cord-000372-wzwpyvll	394	31	198	198	CD
cord-000372-wzwpyvll	394	32	]	]	-RRB-
cord-000372-wzwpyvll	394	33	.	.	.
cord-000372-wzwpyvll	395	1	Nup98	Nup98	NNP
cord-000372-wzwpyvll	395	2	,	,	,
cord-000372-wzwpyvll	395	3	Nup153	nup153	CD
cord-000372-wzwpyvll	395	4	and	and	CC
cord-000372-wzwpyvll	395	5	Nup62	Nup62	NNP
cord-000372-wzwpyvll	395	6	are	be	VBP
cord-000372-wzwpyvll	395	7	proteolyzed	proteolyze	VBN
cord-000372-wzwpyvll	395	8	in	in	IN
cord-000372-wzwpyvll	395	9	PV	pv	NN
cord-000372-wzwpyvll	395	10	-	-	HYPH
cord-000372-wzwpyvll	395	11	infected	infect	VBN
cord-000372-wzwpyvll	395	12	cells	cell	NNS
cord-000372-wzwpyvll	395	13	following	follow	VBG
cord-000372-wzwpyvll	395	14	different	different	JJ
cord-000372-wzwpyvll	395	15	kinetics	kinetic	NNS
cord-000372-wzwpyvll	395	16	.	.	.
cord-000372-wzwpyvll	396	1	Thus	thus	RB
cord-000372-wzwpyvll	396	2	,	,	,
cord-000372-wzwpyvll	396	3	Nup98	Nup98	NNP
cord-000372-wzwpyvll	396	4	is	be	VBZ
cord-000372-wzwpyvll	396	5	the	the	DT
cord-000372-wzwpyvll	396	6	cleaved	cleaved	JJ
cord-000372-wzwpyvll	396	7	early	early	RB
cord-000372-wzwpyvll	396	8	after	after	IN
cord-000372-wzwpyvll	396	9	infection	infection	NN
cord-000372-wzwpyvll	396	10	(	(	-LRB-
cord-000372-wzwpyvll	396	11	from	from	IN
cord-000372-wzwpyvll	396	12	1	1	CD
cord-000372-wzwpyvll	396	13	hpi	hpi	NNP
cord-000372-wzwpyvll	396	14	)	)	-RRB-
cord-000372-wzwpyvll	396	15	,	,	,
cord-000372-wzwpyvll	396	16	whereas	whereas	IN
cord-000372-wzwpyvll	396	17	Nup153	nup153	CD
cord-000372-wzwpyvll	396	18	and	and	CC
cord-000372-wzwpyvll	396	19	Nup62	Nup62	NNP
cord-000372-wzwpyvll	396	20	are	be	VBP
cord-000372-wzwpyvll	396	21	targeted	target	VBN
cord-000372-wzwpyvll	396	22	at	at	IN
cord-000372-wzwpyvll	396	23	late	late	JJ
cord-000372-wzwpyvll	396	24	times	time	NNS
cord-000372-wzwpyvll	396	25	after	after	IN
cord-000372-wzwpyvll	396	26	infection	infection	NN
cord-000372-wzwpyvll	396	27	(	(	-LRB-
cord-000372-wzwpyvll	396	28	from	from	IN
cord-000372-wzwpyvll	396	29	4	4	CD
cord-000372-wzwpyvll	396	30	hpi	hpi	NNP
cord-000372-wzwpyvll	396	31	)	)	-RRB-
cord-000372-wzwpyvll	397	1	[	[	-LRB-
cord-000372-wzwpyvll	397	2	15	15	CD
cord-000372-wzwpyvll	397	3	,	,	,
cord-000372-wzwpyvll	397	4	16	16	CD
cord-000372-wzwpyvll	397	5	]	]	-RRB-
cord-000372-wzwpyvll	397	6	.	.	.
cord-000372-wzwpyvll	398	1	In	in	IN
cord-000372-wzwpyvll	398	2	agreement	agreement	NN
cord-000372-wzwpyvll	398	3	with	with	IN
cord-000372-wzwpyvll	398	4	these	these	DT
cord-000372-wzwpyvll	398	5	findings	finding	NNS
cord-000372-wzwpyvll	398	6	,	,	,
cord-000372-wzwpyvll	398	7	cleavage	cleavage	NN
cord-000372-wzwpyvll	398	8	of	of	IN
cord-000372-wzwpyvll	398	9	Nup98	Nup98	NNP
cord-000372-wzwpyvll	398	10	is	be	VBZ
cord-000372-wzwpyvll	398	11	induced	induce	VBN
cord-000372-wzwpyvll	398	12	even	even	RB
cord-000372-wzwpyvll	398	13	in	in	IN
cord-000372-wzwpyvll	398	14	presence	presence	NN
cord-000372-wzwpyvll	398	15	of	of	IN
cord-000372-wzwpyvll	398	16	inhibitors	inhibitor	NNS
cord-000372-wzwpyvll	398	17	of	of	IN
cord-000372-wzwpyvll	398	18	PV	PV	NNP
cord-000372-wzwpyvll	398	19	replication	replication	NN
cord-000372-wzwpyvll	398	20	,	,	,
cord-000372-wzwpyvll	398	21	suggesting	suggest	VBG
cord-000372-wzwpyvll	398	22	that	that	IN
cord-000372-wzwpyvll	398	23	small	small	JJ
cord-000372-wzwpyvll	398	24	amounts	amount	NNS
cord-000372-wzwpyvll	398	25	of	of	IN
cord-000372-wzwpyvll	398	26	viral	viral	JJ
cord-000372-wzwpyvll	398	27	proteins	protein	NNS
cord-000372-wzwpyvll	398	28	are	be	VBP
cord-000372-wzwpyvll	398	29	sufficient	sufficient	JJ
cord-000372-wzwpyvll	398	30	for	for	IN
cord-000372-wzwpyvll	398	31	this	this	DT
cord-000372-wzwpyvll	398	32	proteolysis	proteolysis	NN
cord-000372-wzwpyvll	398	33	to	to	TO
cord-000372-wzwpyvll	398	34	occur	occur	VB
cord-000372-wzwpyvll	398	35	.	.	.
cord-000372-wzwpyvll	399	1	However	however	RB
cord-000372-wzwpyvll	399	2	,	,	,
cord-000372-wzwpyvll	399	3	cleavage	cleavage	NN
cord-000372-wzwpyvll	399	4	of	of	IN
cord-000372-wzwpyvll	399	5	Nup153	nup153	CD
cord-000372-wzwpyvll	399	6	,	,	,
cord-000372-wzwpyvll	399	7	and	and	CC
cord-000372-wzwpyvll	399	8	Nup62	Nup62	NNP
cord-000372-wzwpyvll	399	9	are	be	VBP
cord-000372-wzwpyvll	399	10	efficiently	efficiently	RB
cord-000372-wzwpyvll	399	11	prevented	prevent	VBN
cord-000372-wzwpyvll	399	12	on	on	IN
cord-000372-wzwpyvll	399	13	arrest	arrest	NN
cord-000372-wzwpyvll	399	14	of	of	IN
cord-000372-wzwpyvll	399	15	viral	viral	JJ
cord-000372-wzwpyvll	399	16	replication	replication	NN
cord-000372-wzwpyvll	399	17	,	,	,
cord-000372-wzwpyvll	399	18	probably	probably	RB
cord-000372-wzwpyvll	399	19	because	because	IN
cord-000372-wzwpyvll	399	20	they	-PRON-	PRP
cord-000372-wzwpyvll	399	21	are	be	VBP
cord-000372-wzwpyvll	399	22	only	only	RB
cord-000372-wzwpyvll	399	23	efficiently	efficiently	RB
cord-000372-wzwpyvll	399	24	achieved	achieve	VBN
cord-000372-wzwpyvll	399	25	when	when	WRB
cord-000372-wzwpyvll	399	26	large	large	JJ
cord-000372-wzwpyvll	399	27	amounts	amount	NNS
cord-000372-wzwpyvll	399	28	of	of	IN
cord-000372-wzwpyvll	399	29	viral	viral	JJ
cord-000372-wzwpyvll	399	30	proteins	protein	NNS
cord-000372-wzwpyvll	399	31	are	be	VBP
cord-000372-wzwpyvll	399	32	produced	produce	VBN
cord-000372-wzwpyvll	399	33	[	[	-LRB-
cord-000372-wzwpyvll	399	34	16	16	CD
cord-000372-wzwpyvll	399	35	]	]	-RRB-
cord-000372-wzwpyvll	399	36	.	.	.
cord-000372-wzwpyvll	400	1	Therefore	therefore	RB
cord-000372-wzwpyvll	400	2	,	,	,
cord-000372-wzwpyvll	400	3	Nup98	Nup98	NNP
cord-000372-wzwpyvll	400	4	,	,	,
cord-000372-wzwpyvll	400	5	Nup153	nup153	CD
cord-000372-wzwpyvll	400	6	,	,	,
cord-000372-wzwpyvll	400	7	and	and	CC
cord-000372-wzwpyvll	400	8	Nup62	Nup62	NNP
cord-000372-wzwpyvll	400	9	exhibit	exhibit	VBP
cord-000372-wzwpyvll	400	10	different	different	JJ
cord-000372-wzwpyvll	400	11	susceptibilities	susceptibility	NNS
cord-000372-wzwpyvll	400	12	to	to	IN
cord-000372-wzwpyvll	400	13	PV	pv	NN
cord-000372-wzwpyvll	400	14	replication	replication	NN
cord-000372-wzwpyvll	400	15	,	,	,
cord-000372-wzwpyvll	400	16	thus	thus	RB
cord-000372-wzwpyvll	400	17	PV	PV	NNP
cord-000372-wzwpyvll	400	18	might	may	MD
cord-000372-wzwpyvll	400	19	have	have	VB
cord-000372-wzwpyvll	400	20	a	a	DT
cord-000372-wzwpyvll	400	21	gradual	gradual	JJ
cord-000372-wzwpyvll	400	22	impact	impact	NN
cord-000372-wzwpyvll	400	23	on	on	IN
cord-000372-wzwpyvll	400	24	the	the	DT
cord-000372-wzwpyvll	400	25	nuclear	nuclear	JJ
cord-000372-wzwpyvll	400	26	-	-	HYPH
cord-000372-wzwpyvll	400	27	cytoplasmic	cytoplasmic	JJ
cord-000372-wzwpyvll	400	28	trafficking	trafficking	NN
cord-000372-wzwpyvll	400	29	machinery	machinery	NN
cord-000372-wzwpyvll	400	30	.	.	.
cord-000372-wzwpyvll	401	1	Nup153	nup153	CD
cord-000372-wzwpyvll	401	2	is	be	VBZ
cord-000372-wzwpyvll	401	3	also	also	RB
cord-000372-wzwpyvll	401	4	proteolyzed	proteolyze	VBN
cord-000372-wzwpyvll	401	5	by	by	IN
cord-000372-wzwpyvll	401	6	caspase-3	caspase-3	NNP
cord-000372-wzwpyvll	401	7	and	and	CC
cord-000372-wzwpyvll	401	8	caspase-9	caspase-9	NNP
cord-000372-wzwpyvll	401	9	during	during	IN
cord-000372-wzwpyvll	401	10	apoptosis	apoptosis	NN
cord-000372-wzwpyvll	401	11	induction	induction	NN
cord-000372-wzwpyvll	401	12	;	;	:
cord-000372-wzwpyvll	401	13	however	however	RB
cord-000372-wzwpyvll	401	14	,	,	,
cord-000372-wzwpyvll	401	15	the	the	DT
cord-000372-wzwpyvll	401	16	involvement	involvement	NN
cord-000372-wzwpyvll	401	17	of	of	IN
cord-000372-wzwpyvll	401	18	these	these	DT
cord-000372-wzwpyvll	401	19	cellular	cellular	JJ
cord-000372-wzwpyvll	401	20	proteases	protease	NNS
cord-000372-wzwpyvll	401	21	in	in	IN
cord-000372-wzwpyvll	401	22	PV	pv	NN
cord-000372-wzwpyvll	401	23	-	-	HYPH
cord-000372-wzwpyvll	401	24	induced	induce	VBN
cord-000372-wzwpyvll	401	25	Nup	Nup	NNP
cord-000372-wzwpyvll	401	26	cleavage	cleavage	NN
cord-000372-wzwpyvll	401	27	has	have	VBZ
cord-000372-wzwpyvll	401	28	been	be	VBN
cord-000372-wzwpyvll	401	29	ruled	rule	VBN
cord-000372-wzwpyvll	401	30	out	out	RP
cord-000372-wzwpyvll	401	31	by	by	IN
cord-000372-wzwpyvll	401	32	different	different	JJ
cord-000372-wzwpyvll	401	33	laboratories	laboratory	NNS
cord-000372-wzwpyvll	401	34	.	.	.
cord-000372-wzwpyvll	402	1	First	first	RB
cord-000372-wzwpyvll	402	2	,	,	,
cord-000372-wzwpyvll	402	3	Nup153	nup153	CD
cord-000372-wzwpyvll	402	4	cleavage	cleavage	NN
cord-000372-wzwpyvll	402	5	Journal	Journal	NNP
cord-000372-wzwpyvll	402	6	of	of	IN
cord-000372-wzwpyvll	402	7	Biomedicine	Biomedicine	NNP
cord-000372-wzwpyvll	402	8	and	and	CC
cord-000372-wzwpyvll	402	9	Biotechnology	Biotechnology	NNP
cord-000372-wzwpyvll	402	10	13	13	CD
cord-000372-wzwpyvll	402	11	products	product	NNS
cord-000372-wzwpyvll	402	12	generated	generate	VBN
cord-000372-wzwpyvll	402	13	upon	upon	IN
cord-000372-wzwpyvll	402	14	caspase	caspase	NN
cord-000372-wzwpyvll	402	15	activation	activation	NN
cord-000372-wzwpyvll	402	16	differ	differ	VBP
cord-000372-wzwpyvll	402	17	to	to	IN
cord-000372-wzwpyvll	402	18	those	those	DT
cord-000372-wzwpyvll	402	19	found	find	VBN
cord-000372-wzwpyvll	402	20	in	in	IN
cord-000372-wzwpyvll	402	21	PV	pv	NN
cord-000372-wzwpyvll	402	22	-	-	HYPH
cord-000372-wzwpyvll	402	23	infected	infect	VBN
cord-000372-wzwpyvll	402	24	cells	cell	NNS
cord-000372-wzwpyvll	402	25	[	[	-LRB-
cord-000372-wzwpyvll	402	26	159	159	CD
cord-000372-wzwpyvll	402	27	]	]	-RRB-
cord-000372-wzwpyvll	402	28	.	.	.
cord-000372-wzwpyvll	403	1	In	in	IN
cord-000372-wzwpyvll	403	2	addition	addition	NN
cord-000372-wzwpyvll	403	3	,	,	,
cord-000372-wzwpyvll	403	4	Nup62	Nup62	NNP
cord-000372-wzwpyvll	403	5	is	be	VBZ
cord-000372-wzwpyvll	403	6	cleaved	cleave	VBN
cord-000372-wzwpyvll	403	7	in	in	IN
cord-000372-wzwpyvll	403	8	PV	pv	NN
cord-000372-wzwpyvll	403	9	-	-	HYPH
cord-000372-wzwpyvll	403	10	infected	infect	VBN
cord-000372-wzwpyvll	403	11	cells	cell	NNS
cord-000372-wzwpyvll	403	12	,	,	,
cord-000372-wzwpyvll	403	13	but	but	CC
cord-000372-wzwpyvll	403	14	it	-PRON-	PRP
cord-000372-wzwpyvll	403	15	remains	remain	VBZ
cord-000372-wzwpyvll	403	16	intact	intact	JJ
cord-000372-wzwpyvll	403	17	despite	despite	IN
cord-000372-wzwpyvll	403	18	caspase	caspase	NN
cord-000372-wzwpyvll	403	19	activation	activation	NN
cord-000372-wzwpyvll	403	20	[	[	-LRB-
cord-000372-wzwpyvll	403	21	199	199	CD
cord-000372-wzwpyvll	403	22	]	]	-RRB-
cord-000372-wzwpyvll	403	23	.	.	.
cord-000372-wzwpyvll	404	1	Most	most	RBS
cord-000372-wzwpyvll	404	2	importantly	importantly	RB
cord-000372-wzwpyvll	404	3	,	,	,
cord-000372-wzwpyvll	404	4	PV	pv	NN
cord-000372-wzwpyvll	404	5	-	-	HYPH
cord-000372-wzwpyvll	404	6	induced	induce	VBN
cord-000372-wzwpyvll	404	7	NPC	NPC	NNP
cord-000372-wzwpyvll	404	8	structural	structural	JJ
cord-000372-wzwpyvll	404	9	damage	damage	NN
cord-000372-wzwpyvll	404	10	takes	take	VBZ
cord-000372-wzwpyvll	404	11	place	place	NN
cord-000372-wzwpyvll	404	12	in	in	IN
cord-000372-wzwpyvll	404	13	cells	cell	NNS
cord-000372-wzwpyvll	404	14	lacking	lack	VBG
cord-000372-wzwpyvll	404	15	caspase	caspase	NN
cord-000372-wzwpyvll	404	16	3	3	CD
cord-000372-wzwpyvll	404	17	and	and	CC
cord-000372-wzwpyvll	404	18	9	9	CD
cord-000372-wzwpyvll	404	19	[	[	-LRB-
cord-000372-wzwpyvll	404	20	196	196	CD
cord-000372-wzwpyvll	404	21	]	]	-RRB-
cord-000372-wzwpyvll	404	22	,	,	,
cord-000372-wzwpyvll	404	23	and	and	CC
cord-000372-wzwpyvll	404	24	Nup153	Nup153	.
cord-000372-wzwpyvll	405	1	and	and	CC
cord-000372-wzwpyvll	405	2	Nup62	Nup62	NNP
cord-000372-wzwpyvll	405	3	are	be	VBP
cord-000372-wzwpyvll	405	4	efficiently	efficiently	RB
cord-000372-wzwpyvll	405	5	cleaved	cleave	VBN
cord-000372-wzwpyvll	405	6	in	in	IN
cord-000372-wzwpyvll	405	7	PV	pv	NN
cord-000372-wzwpyvll	405	8	-	-	HYPH
cord-000372-wzwpyvll	405	9	infected	infect	VBN
cord-000372-wzwpyvll	405	10	cells	cell	NNS
cord-000372-wzwpyvll	405	11	even	even	RB
cord-000372-wzwpyvll	405	12	in	in	IN
cord-000372-wzwpyvll	405	13	presence	presence	NN
cord-000372-wzwpyvll	405	14	of	of	IN
cord-000372-wzwpyvll	405	15	the	the	DT
cord-000372-wzwpyvll	405	16	caspase	caspase	JJ
cord-000372-wzwpyvll	405	17	inhibitor	inhibitor	NN
cord-000372-wzwpyvll	405	18	Z	Z	NNP
cord-000372-wzwpyvll	405	19	-	-	HYPH
cord-000372-wzwpyvll	405	20	VAD	VAD	NNP
cord-000372-wzwpyvll	405	21	[	[	-LRB-
cord-000372-wzwpyvll	405	22	159	159	CD
cord-000372-wzwpyvll	405	23	]	]	-RRB-
cord-000372-wzwpyvll	405	24	.	.	.
cord-000372-wzwpyvll	406	1	All	all	RB
cord-000372-wzwpyvll	406	2	together	together	RB
cord-000372-wzwpyvll	406	3	,	,	,
cord-000372-wzwpyvll	406	4	these	these	DT
cord-000372-wzwpyvll	406	5	data	datum	NNS
cord-000372-wzwpyvll	406	6	support	support	VBP
cord-000372-wzwpyvll	406	7	the	the	DT
cord-000372-wzwpyvll	406	8	idea	idea	NN
cord-000372-wzwpyvll	406	9	that	that	IN
cord-000372-wzwpyvll	406	10	one	one	CD
cord-000372-wzwpyvll	406	11	or	or	CC
cord-000372-wzwpyvll	406	12	more	more	JJR
cord-000372-wzwpyvll	406	13	viral	viral	JJ
cord-000372-wzwpyvll	406	14	proteins	protein	NNS
cord-000372-wzwpyvll	406	15	play	play	VBP
cord-000372-wzwpyvll	406	16	a	a	DT
cord-000372-wzwpyvll	406	17	direct	direct	JJ
cord-000372-wzwpyvll	406	18	role	role	NN
cord-000372-wzwpyvll	406	19	in	in	IN
cord-000372-wzwpyvll	406	20	the	the	DT
cord-000372-wzwpyvll	406	21	cleavage	cleavage	NN
cord-000372-wzwpyvll	406	22	of	of	IN
cord-000372-wzwpyvll	406	23	those	those	DT
cord-000372-wzwpyvll	406	24	Nups	Nups	NNP
cord-000372-wzwpyvll	406	25	.	.	.
cord-000372-wzwpyvll	407	1	In	in	IN
cord-000372-wzwpyvll	407	2	agreement	agreement	NN
cord-000372-wzwpyvll	407	3	with	with	IN
cord-000372-wzwpyvll	407	4	this	this	DT
cord-000372-wzwpyvll	407	5	hypothesis	hypothesis	NN
cord-000372-wzwpyvll	407	6	,	,	,
cord-000372-wzwpyvll	407	7	PV	pv	NN
cord-000372-wzwpyvll	407	8	-	-	HYPH
cord-000372-wzwpyvll	407	9	induced	induce	VBN
cord-000372-wzwpyvll	407	10	NPC	NPC	NNP
cord-000372-wzwpyvll	407	11	damage	damage	NN
cord-000372-wzwpyvll	407	12	is	be	VBZ
cord-000372-wzwpyvll	407	13	prevented	prevent	VBN
cord-000372-wzwpyvll	407	14	by	by	IN
cord-000372-wzwpyvll	407	15	PV	PV	NNP
cord-000372-wzwpyvll	407	16	2A	2a	CD
cord-000372-wzwpyvll	407	17	pro	pro	JJ
cord-000372-wzwpyvll	407	18	inhibitors	inhibitor	NNS
cord-000372-wzwpyvll	407	19	such	such	JJ
cord-000372-wzwpyvll	407	20	as	as	IN
cord-000372-wzwpyvll	407	21	elastatinal	elastatinal	JJ
cord-000372-wzwpyvll	407	22	,	,	,
cord-000372-wzwpyvll	407	23	elastase	elastase	NN
cord-000372-wzwpyvll	407	24	,	,	,
cord-000372-wzwpyvll	407	25	and	and	CC
cord-000372-wzwpyvll	407	26	MPCMK	MPCMK	NNP
cord-000372-wzwpyvll	407	27	,	,	,
cord-000372-wzwpyvll	407	28	suggesting	suggest	VBG
cord-000372-wzwpyvll	407	29	an	an	DT
cord-000372-wzwpyvll	407	30	involvement	involvement	NN
cord-000372-wzwpyvll	407	31	of	of	IN
cord-000372-wzwpyvll	407	32	this	this	DT
cord-000372-wzwpyvll	407	33	viral	viral	JJ
cord-000372-wzwpyvll	407	34	protease	protease	NN
cord-000372-wzwpyvll	407	35	in	in	IN
cord-000372-wzwpyvll	407	36	the	the	DT
cord-000372-wzwpyvll	407	37	alteration	alteration	NN
cord-000372-wzwpyvll	407	38	of	of	IN
cord-000372-wzwpyvll	407	39	NPC	NPC	NNP
cord-000372-wzwpyvll	407	40	[	[	-LRB-
cord-000372-wzwpyvll	407	41	196	196	CD
cord-000372-wzwpyvll	407	42	]	]	-RRB-
cord-000372-wzwpyvll	407	43	.	.	.
cord-000372-wzwpyvll	408	1	Indeed	indeed	RB
cord-000372-wzwpyvll	408	2	,	,	,
cord-000372-wzwpyvll	408	3	individual	individual	JJ
cord-000372-wzwpyvll	408	4	expression	expression	NN
cord-000372-wzwpyvll	408	5	of	of	IN
cord-000372-wzwpyvll	408	6	PV	PV	NNP
cord-000372-wzwpyvll	408	7	2A	2a	CD
cord-000372-wzwpyvll	408	8	pro	pro	JJ
cord-000372-wzwpyvll	408	9	in	in	IN
cord-000372-wzwpyvll	408	10	HeLa	HeLa	NNP
cord-000372-wzwpyvll	408	11	cells	cell	NNS
cord-000372-wzwpyvll	408	12	as	as	RB
cord-000372-wzwpyvll	408	13	well	well	RB
cord-000372-wzwpyvll	408	14	as	as	IN
cord-000372-wzwpyvll	408	15	addition	addition	NN
cord-000372-wzwpyvll	408	16	of	of	IN
cord-000372-wzwpyvll	408	17	this	this	DT
cord-000372-wzwpyvll	408	18	protease	protease	NN
cord-000372-wzwpyvll	408	19	to	to	IN
cord-000372-wzwpyvll	408	20	cell	cell	NN
cord-000372-wzwpyvll	408	21	-	-	HYPH
cord-000372-wzwpyvll	408	22	free	free	JJ
cord-000372-wzwpyvll	408	23	systems	system	NNS
cord-000372-wzwpyvll	408	24	gives	give	VBZ
cord-000372-wzwpyvll	408	25	rise	rise	NN
cord-000372-wzwpyvll	408	26	to	to	IN
cord-000372-wzwpyvll	408	27	Nup98	Nup98	NNP
cord-000372-wzwpyvll	408	28	,	,	,
cord-000372-wzwpyvll	408	29	Nup62	Nup62	NNP
cord-000372-wzwpyvll	408	30	,	,	,
cord-000372-wzwpyvll	408	31	and	and	CC
cord-000372-wzwpyvll	408	32	Nup153	nup153	CD
cord-000372-wzwpyvll	408	33	cleavage	cleavage	NN
cord-000372-wzwpyvll	408	34	[	[	-LRB-
cord-000372-wzwpyvll	408	35	16	16	CD
cord-000372-wzwpyvll	408	36	,	,	,
cord-000372-wzwpyvll	408	37	17	17	CD
cord-000372-wzwpyvll	408	38	,	,	,
cord-000372-wzwpyvll	408	39	200	200	CD
cord-000372-wzwpyvll	408	40	]	]	-RRB-
cord-000372-wzwpyvll	408	41	.	.	.
cord-000372-wzwpyvll	409	1	In	in	IN
cord-000372-wzwpyvll	409	2	agreement	agreement	NN
cord-000372-wzwpyvll	409	3	with	with	IN
cord-000372-wzwpyvll	409	4	the	the	DT
cord-000372-wzwpyvll	409	5	data	datum	NNS
cord-000372-wzwpyvll	409	6	obtained	obtain	VBN
cord-000372-wzwpyvll	409	7	from	from	IN
cord-000372-wzwpyvll	409	8	PV	pv	NN
cord-000372-wzwpyvll	409	9	-	-	HYPH
cord-000372-wzwpyvll	409	10	infected	infect	VBN
cord-000372-wzwpyvll	409	11	cells	cell	NNS
cord-000372-wzwpyvll	409	12	,	,	,
cord-000372-wzwpyvll	409	13	on	on	IN
cord-000372-wzwpyvll	409	14	PV	PV	NNP
cord-000372-wzwpyvll	409	15	2A	2a	CD
cord-000372-wzwpyvll	409	16	pro	pro	JJ
cord-000372-wzwpyvll	409	17	expression	expression	NN
cord-000372-wzwpyvll	409	18	in	in	IN
cord-000372-wzwpyvll	409	19	HeLa	HeLa	NNP
cord-000372-wzwpyvll	409	20	cells	cell	NNS
cord-000372-wzwpyvll	409	21	,	,	,
cord-000372-wzwpyvll	409	22	Nup98	Nup98	NNP
cord-000372-wzwpyvll	409	23	is	be	VBZ
cord-000372-wzwpyvll	409	24	cleaved	cleave	VBN
cord-000372-wzwpyvll	409	25	faster	fast	RBR
cord-000372-wzwpyvll	409	26	than	than	IN
cord-000372-wzwpyvll	409	27	Nup62	Nup62	NNP
cord-000372-wzwpyvll	410	1	and	and	CC
cord-000372-wzwpyvll	410	2	Nup153	nup153	CD
cord-000372-wzwpyvll	410	3	,	,	,
cord-000372-wzwpyvll	410	4	which	which	WDT
cord-000372-wzwpyvll	410	5	suggests	suggest	VBZ
cord-000372-wzwpyvll	410	6	the	the	DT
cord-000372-wzwpyvll	410	7	presence	presence	NN
cord-000372-wzwpyvll	410	8	of	of	IN
cord-000372-wzwpyvll	410	9	optimal	optimal	JJ
cord-000372-wzwpyvll	410	10	cleavage	cleavage	NN
cord-000372-wzwpyvll	410	11	sites	site	NNS
cord-000372-wzwpyvll	410	12	in	in	IN
cord-000372-wzwpyvll	410	13	this	this	DT
cord-000372-wzwpyvll	410	14	protein	protein	NN
cord-000372-wzwpyvll	410	15	[	[	-LRB-
cord-000372-wzwpyvll	410	16	17	17	CD
cord-000372-wzwpyvll	410	17	]	]	-RRB-
cord-000372-wzwpyvll	410	18	.	.	.
cord-000372-wzwpyvll	411	1	Proteolysis	Proteolysis	NNP
cord-000372-wzwpyvll	411	2	of	of	IN
cord-000372-wzwpyvll	411	3	Nup98	Nup98	NNP
cord-000372-wzwpyvll	411	4	in	in	IN
cord-000372-wzwpyvll	411	5	PV	PV	NNP
cord-000372-wzwpyvll	411	6	-	-	HYPH
cord-000372-wzwpyvll	411	7	infected	infect	VBN
cord-000372-wzwpyvll	411	8	cells	cell	NNS
cord-000372-wzwpyvll	411	9	as	as	RB
cord-000372-wzwpyvll	411	10	well	well	RB
cord-000372-wzwpyvll	411	11	as	as	IN
cord-000372-wzwpyvll	411	12	in	in	IN
cord-000372-wzwpyvll	411	13	cell	cell	NN
cord-000372-wzwpyvll	411	14	-	-	HYPH
cord-000372-wzwpyvll	411	15	free	free	JJ
cord-000372-wzwpyvll	411	16	systems	system	NNS
cord-000372-wzwpyvll	411	17	generates	generate	VBZ
cord-000372-wzwpyvll	411	18	two	two	CD
cord-000372-wzwpyvll	411	19	different	different	JJ
cord-000372-wzwpyvll	411	20	cleavage	cleavage	NN
cord-000372-wzwpyvll	411	21	products	product	NNS
cord-000372-wzwpyvll	411	22	of	of	IN
cord-000372-wzwpyvll	411	23	around	around	RB
cord-000372-wzwpyvll	411	24	50	50	CD
cord-000372-wzwpyvll	411	25	-	-	SYM
cord-000372-wzwpyvll	411	26	65	65	CD
cord-000372-wzwpyvll	411	27	KDa	KDa	NNS
cord-000372-wzwpyvll	411	28	and	and	CC
cord-000372-wzwpyvll	411	29	35	35	CD
cord-000372-wzwpyvll	411	30	KDa	KDa	NNS
cord-000372-wzwpyvll	411	31	[	[	-LRB-
cord-000372-wzwpyvll	411	32	16	16	CD
cord-000372-wzwpyvll	411	33	]	]	-RRB-
cord-000372-wzwpyvll	411	34	.	.	.
cord-000372-wzwpyvll	412	1	There	there	EX
cord-000372-wzwpyvll	412	2	are	be	VBP
cord-000372-wzwpyvll	412	3	two	two	CD
cord-000372-wzwpyvll	412	4	optimal	optimal	JJ
cord-000372-wzwpyvll	412	5	cleavage	cleavage	NN
cord-000372-wzwpyvll	412	6	sites	site	NNS
cord-000372-wzwpyvll	412	7	in	in	IN
cord-000372-wzwpyvll	412	8	Nup98	Nup98	NNP
cord-000372-wzwpyvll	412	9	for	for	IN
cord-000372-wzwpyvll	412	10	PV	PV	NNP
cord-000372-wzwpyvll	412	11	2A	2a	CD
cord-000372-wzwpyvll	412	12	pro	pro	NNP
cord-000372-wzwpyvll	412	13	located	locate	VBN
cord-000372-wzwpyvll	412	14	between	between	IN
cord-000372-wzwpyvll	412	15	aminoacids	aminoacid	NNS
cord-000372-wzwpyvll	412	16	373	373	CD
cord-000372-wzwpyvll	412	17	-	-	SYM
cord-000372-wzwpyvll	412	18	374	374	CD
cord-000372-wzwpyvll	412	19	and	and	CC
cord-000372-wzwpyvll	412	20	551	551	CD
cord-000372-wzwpyvll	412	21	-	-	SYM
cord-000372-wzwpyvll	412	22	552	552	CD
cord-000372-wzwpyvll	412	23	,	,	,
cord-000372-wzwpyvll	412	24	containing	contain	VBG
cord-000372-wzwpyvll	412	25	Gly	Gly	NNP
cord-000372-wzwpyvll	412	26	at	at	IN
cord-000372-wzwpyvll	412	27	P1	P1	NNP
cord-000372-wzwpyvll	412	28	,	,	,
cord-000372-wzwpyvll	412	29	Thr	Thr	NNP
cord-000372-wzwpyvll	412	30	at	at	IN
cord-000372-wzwpyvll	412	31	P2	P2	NNP
cord-000372-wzwpyvll	412	32	,	,	,
cord-000372-wzwpyvll	412	33	and	and	CC
cord-000372-wzwpyvll	412	34	Leu	Leu	NNP
cord-000372-wzwpyvll	412	35	at	at	IN
cord-000372-wzwpyvll	412	36	P4	P4	NNP
cord-000372-wzwpyvll	412	37	.	.	.
cord-000372-wzwpyvll	413	1	Hydrolysis	hydrolysis	NN
cord-000372-wzwpyvll	413	2	at	at	IN
cord-000372-wzwpyvll	413	3	both	both	DT
cord-000372-wzwpyvll	413	4	sites	site	NNS
cord-000372-wzwpyvll	413	5	results	result	NNS
cord-000372-wzwpyvll	413	6	in	in	IN
cord-000372-wzwpyvll	413	7	N	n	CD
cord-000372-wzwpyvll	413	8	-	-	HYPH
cord-000372-wzwpyvll	413	9	and	and	CC
cord-000372-wzwpyvll	413	10	Cterminal	Cterminal	NNP
cord-000372-wzwpyvll	413	11	products	product	NNS
cord-000372-wzwpyvll	413	12	with	with	IN
cord-000372-wzwpyvll	413	13	predicted	predict	VBN
cord-000372-wzwpyvll	413	14	molecular	molecular	JJ
cord-000372-wzwpyvll	413	15	masses	masse	NNS
cord-000372-wzwpyvll	413	16	of	of	IN
cord-000372-wzwpyvll	413	17	37	37	CD
cord-000372-wzwpyvll	413	18	and	and	CC
cord-000372-wzwpyvll	413	19	53	53	CD
cord-000372-wzwpyvll	413	20	or	or	CC
cord-000372-wzwpyvll	413	21	55	55	CD
cord-000372-wzwpyvll	413	22	and	and	CC
cord-000372-wzwpyvll	413	23	35	35	CD
cord-000372-wzwpyvll	413	24	KDa	KDa	NNS
cord-000372-wzwpyvll	413	25	,	,	,
cord-000372-wzwpyvll	413	26	in	in	IN
cord-000372-wzwpyvll	413	27	good	good	JJ
cord-000372-wzwpyvll	413	28	agreement	agreement	NN
cord-000372-wzwpyvll	413	29	with	with	IN
cord-000372-wzwpyvll	413	30	the	the	DT
cord-000372-wzwpyvll	413	31	size	size	NN
cord-000372-wzwpyvll	413	32	of	of	IN
cord-000372-wzwpyvll	413	33	the	the	DT
cord-000372-wzwpyvll	413	34	peptides	peptide	NNS
cord-000372-wzwpyvll	413	35	detected	detect	VBN
cord-000372-wzwpyvll	413	36	experimentally	experimentally	RB
cord-000372-wzwpyvll	413	37	in	in	IN
cord-000372-wzwpyvll	413	38	PV	pv	NN
cord-000372-wzwpyvll	413	39	-	-	HYPH
cord-000372-wzwpyvll	413	40	infected	infect	VBN
cord-000372-wzwpyvll	413	41	cells	cell	NNS
cord-000372-wzwpyvll	413	42	and	and	CC
cord-000372-wzwpyvll	413	43	2A	2a	CD
cord-000372-wzwpyvll	413	44	-	-	HYPH
cord-000372-wzwpyvll	413	45	treated	treat	VBN
cord-000372-wzwpyvll	413	46	HeLa	HeLa	NNP
cord-000372-wzwpyvll	413	47	extracts	extract	NNS
cord-000372-wzwpyvll	413	48	[	[	-LRB-
cord-000372-wzwpyvll	413	49	16	16	CD
cord-000372-wzwpyvll	413	50	,	,	,
cord-000372-wzwpyvll	413	51	17	17	CD
cord-000372-wzwpyvll	413	52	]	]	-RRB-
cord-000372-wzwpyvll	413	53	.	.	.
cord-000372-wzwpyvll	414	1	An	an	DT
cord-000372-wzwpyvll	414	2	explanation	explanation	NN
cord-000372-wzwpyvll	414	3	for	for	IN
cord-000372-wzwpyvll	414	4	the	the	DT
cord-000372-wzwpyvll	414	5	delayed	delay	VBN
cord-000372-wzwpyvll	414	6	kinetics	kinetics	NN
cord-000372-wzwpyvll	414	7	of	of	IN
cord-000372-wzwpyvll	414	8	Nup62	Nup62	NNP
cord-000372-wzwpyvll	414	9	and	and	CC
cord-000372-wzwpyvll	414	10	Nup153	Nup153	.
cord-000372-wzwpyvll	414	11	with	with	IN
cord-000372-wzwpyvll	414	12	respect	respect	NN
cord-000372-wzwpyvll	414	13	to	to	IN
cord-000372-wzwpyvll	414	14	Nup98	Nup98	NNP
cord-000372-wzwpyvll	414	15	is	be	VBZ
cord-000372-wzwpyvll	414	16	that	that	DT
cord-000372-wzwpyvll	414	17	optimal	optimal	JJ
cord-000372-wzwpyvll	414	18	PV	pv	NN
cord-000372-wzwpyvll	414	19	2A	2a	NN
cord-000372-wzwpyvll	414	20	pro	pro	JJ
cord-000372-wzwpyvll	414	21	cleavage	cleavage	NN
cord-000372-wzwpyvll	414	22	sites	site	NNS
cord-000372-wzwpyvll	414	23	were	be	VBD
cord-000372-wzwpyvll	414	24	not	not	RB
cord-000372-wzwpyvll	414	25	found	find	VBN
cord-000372-wzwpyvll	414	26	in	in	IN
cord-000372-wzwpyvll	414	27	these	these	DT
cord-000372-wzwpyvll	414	28	Nups	Nups	NNP
cord-000372-wzwpyvll	414	29	(	(	-LRB-
cord-000372-wzwpyvll	414	30	unpublished	unpublished	JJ
cord-000372-wzwpyvll	414	31	data	datum	NNS
cord-000372-wzwpyvll	414	32	)	)	-RRB-
cord-000372-wzwpyvll	414	33	.	.	.
cord-000372-wzwpyvll	415	1	Recently	recently	RB
cord-000372-wzwpyvll	415	2	,	,	,
cord-000372-wzwpyvll	415	3	Park	Park	NNP
cord-000372-wzwpyvll	415	4	and	and	CC
cord-000372-wzwpyvll	415	5	colleagues	colleague	NNS
cord-000372-wzwpyvll	415	6	have	have	VBP
cord-000372-wzwpyvll	415	7	reported	report	VBN
cord-000372-wzwpyvll	415	8	that	that	IN
cord-000372-wzwpyvll	415	9	PV	PV	NNP
cord-000372-wzwpyvll	415	10	2A	2a	NN
cord-000372-wzwpyvll	415	11	pro	pro	JJ
cord-000372-wzwpyvll	415	12	directly	directly	RB
cord-000372-wzwpyvll	415	13	cleaves	cleave	VBZ
cord-000372-wzwpyvll	415	14	Nup62	Nup62	NNP
cord-000372-wzwpyvll	415	15	at	at	IN
cord-000372-wzwpyvll	415	16	six	six	CD
cord-000372-wzwpyvll	415	17	different	different	JJ
cord-000372-wzwpyvll	415	18	positions	position	NNS
cord-000372-wzwpyvll	415	19	rendering	render	VBG
cord-000372-wzwpyvll	415	20	multiple	multiple	JJ
cord-000372-wzwpyvll	415	21	proteolytic	proteolytic	JJ
cord-000372-wzwpyvll	415	22	products	product	NNS
cord-000372-wzwpyvll	415	23	.	.	.
cord-000372-wzwpyvll	416	1	These	these	DT
cord-000372-wzwpyvll	416	2	cleavage	cleavage	NN
cord-000372-wzwpyvll	416	3	sites	site	NNS
cord-000372-wzwpyvll	416	4	are	be	VBP
cord-000372-wzwpyvll	416	5	located	locate	VBN
cord-000372-wzwpyvll	416	6	between	between	IN
cord-000372-wzwpyvll	416	7	aminoacids	aminoacid	NNS
cord-000372-wzwpyvll	416	8	103	103	CD
cord-000372-wzwpyvll	416	9	and	and	CC
cord-000372-wzwpyvll	416	10	298	298	CD
cord-000372-wzwpyvll	416	11	,	,	,
cord-000372-wzwpyvll	416	12	thus	thus	RB
cord-000372-wzwpyvll	416	13	releasing	release	VBG
cord-000372-wzwpyvll	416	14	the	the	DT
cord-000372-wzwpyvll	416	15	FG	FG	NNP
cord-000372-wzwpyvll	416	16	-	-	HYPH
cord-000372-wzwpyvll	416	17	rich	rich	JJ
cord-000372-wzwpyvll	416	18	region	region	NN
cord-000372-wzwpyvll	416	19	from	from	IN
cord-000372-wzwpyvll	416	20	the	the	DT
cord-000372-wzwpyvll	416	21	protein	protein	NN
cord-000372-wzwpyvll	416	22	core	core	NN
cord-000372-wzwpyvll	416	23	[	[	-LRB-
cord-000372-wzwpyvll	416	24	200	200	CD
cord-000372-wzwpyvll	416	25	]	]	-RRB-
cord-000372-wzwpyvll	416	26	.	.	.
cord-000372-wzwpyvll	417	1	Functionally	functionally	RB
cord-000372-wzwpyvll	417	2	,	,	,
cord-000372-wzwpyvll	417	3	loss	loss	NN
cord-000372-wzwpyvll	417	4	of	of	IN
cord-000372-wzwpyvll	417	5	the	the	DT
cord-000372-wzwpyvll	417	6	FG	fg	NN
cord-000372-wzwpyvll	417	7	-	-	HYPH
cord-000372-wzwpyvll	417	8	rich	rich	JJ
cord-000372-wzwpyvll	417	9	region	region	NN
cord-000372-wzwpyvll	417	10	might	may	MD
cord-000372-wzwpyvll	417	11	make	make	VB
cord-000372-wzwpyvll	417	12	Nup62	Nup62	NNP
cord-000372-wzwpyvll	417	13	inactive	inactive	JJ
cord-000372-wzwpyvll	417	14	for	for	IN
cord-000372-wzwpyvll	417	15	interaction	interaction	NN
cord-000372-wzwpyvll	417	16	with	with	IN
cord-000372-wzwpyvll	417	17	cargo	cargo	NN
cord-000372-wzwpyvll	417	18	receptors	receptor	NNS
cord-000372-wzwpyvll	417	19	.	.	.
cord-000372-wzwpyvll	418	1	This	this	DT
cord-000372-wzwpyvll	418	2	hypothetical	hypothetical	JJ
cord-000372-wzwpyvll	418	3	mechanism	mechanism	NN
cord-000372-wzwpyvll	418	4	of	of	IN
cord-000372-wzwpyvll	418	5	Nup62	Nup62	NNP
cord-000372-wzwpyvll	418	6	functional	functional	JJ
cord-000372-wzwpyvll	418	7	decoupling	decoupling	NN
cord-000372-wzwpyvll	418	8	could	could	MD
cord-000372-wzwpyvll	418	9	be	be	VB
cord-000372-wzwpyvll	418	10	extrapolated	extrapolate	VBN
cord-000372-wzwpyvll	418	11	to	to	IN
cord-000372-wzwpyvll	418	12	Nup98	Nup98	NNP
cord-000372-wzwpyvll	419	1	and	and	CC
cord-000372-wzwpyvll	419	2	Nup153	nup153	DT
cord-000372-wzwpyvll	419	3	(	(	-LRB-
cord-000372-wzwpyvll	419	4	Figure	figure	NN
cord-000372-wzwpyvll	419	5	4	4	CD
cord-000372-wzwpyvll	419	6	)	)	-RRB-
cord-000372-wzwpyvll	419	7	.	.	.
cord-000372-wzwpyvll	420	1	However	however	RB
cord-000372-wzwpyvll	420	2	,	,	,
cord-000372-wzwpyvll	420	3	it	-PRON-	PRP
cord-000372-wzwpyvll	420	4	remains	remain	VBZ
cord-000372-wzwpyvll	420	5	unknown	unknown	JJ
cord-000372-wzwpyvll	420	6	whether	whether	IN
cord-000372-wzwpyvll	420	7	PV	PV	NNP
cord-000372-wzwpyvll	420	8	2A	2a	CD
cord-000372-wzwpyvll	420	9	pro	pro	NNP
cord-000372-wzwpyvll	420	10	is	be	VBZ
cord-000372-wzwpyvll	420	11	able	able	JJ
cord-000372-wzwpyvll	420	12	to	to	TO
cord-000372-wzwpyvll	420	13	directly	directly	RB
cord-000372-wzwpyvll	420	14	cleave	cleave	VB
cord-000372-wzwpyvll	420	15	Nup98	Nup98	NNP
cord-000372-wzwpyvll	420	16	and	and	CC
cord-000372-wzwpyvll	421	1	Nup153	Nup153	NFP
cord-000372-wzwpyvll	421	2	or	or	CC
cord-000372-wzwpyvll	421	3	where	where	WRB
cord-000372-wzwpyvll	421	4	cleavage	cleavage	NN
cord-000372-wzwpyvll	421	5	might	may	MD
cord-000372-wzwpyvll	421	6	occur	occur	VB
cord-000372-wzwpyvll	421	7	.	.	.
cord-000372-wzwpyvll	422	1	Nup98	Nup98	NNP
cord-000372-wzwpyvll	422	2	,	,	,
cord-000372-wzwpyvll	422	3	Nup153	nup153	CD
cord-000372-wzwpyvll	422	4	and	and	CC
cord-000372-wzwpyvll	422	5	Nup62	Nup62	NNP
cord-000372-wzwpyvll	422	6	are	be	VBP
cord-000372-wzwpyvll	422	7	also	also	RB
cord-000372-wzwpyvll	422	8	involved	involve	VBN
cord-000372-wzwpyvll	422	9	in	in	IN
cord-000372-wzwpyvll	422	10	RNA	RNA	NNP
cord-000372-wzwpyvll	422	11	export	export	NN
cord-000372-wzwpyvll	422	12	from	from	IN
cord-000372-wzwpyvll	422	13	the	the	DT
cord-000372-wzwpyvll	422	14	nucleus	nucleus	NN
cord-000372-wzwpyvll	422	15	and	and	CC
cord-000372-wzwpyvll	422	16	therefore	therefore	RB
cord-000372-wzwpyvll	422	17	,	,	,
cord-000372-wzwpyvll	422	18	cleavage	cleavage	NN
cord-000372-wzwpyvll	422	19	by	by	IN
cord-000372-wzwpyvll	422	20	PV	PV	NNP
cord-000372-wzwpyvll	422	21	2A	2a	CD
cord-000372-wzwpyvll	422	22	pro	pro	JJ
cord-000372-wzwpyvll	422	23	might	may	MD
cord-000372-wzwpyvll	422	24	also	also	RB
cord-000372-wzwpyvll	422	25	impact	impact	VB
cord-000372-wzwpyvll	422	26	on	on	IN
cord-000372-wzwpyvll	422	27	this	this	DT
cord-000372-wzwpyvll	422	28	process	process	NN
cord-000372-wzwpyvll	422	29	(	(	-LRB-
cord-000372-wzwpyvll	422	30	Figure	figure	NN
cord-000372-wzwpyvll	422	31	4	4	CD
cord-000372-wzwpyvll	422	32	)	)	-RRB-
cord-000372-wzwpyvll	422	33	.	.	.
cord-000372-wzwpyvll	423	1	However	however	RB
cord-000372-wzwpyvll	423	2	,	,	,
cord-000372-wzwpyvll	423	3	oligo	oligo	NNP
cord-000372-wzwpyvll	423	4	d(T	d(T	NNP
cord-000372-wzwpyvll	423	5	)	)	-RRB-
cord-000372-wzwpyvll	424	1	hybridization	hybridization	NN
cord-000372-wzwpyvll	424	2	studies	study	NNS
cord-000372-wzwpyvll	424	3	showed	show	VBD
cord-000372-wzwpyvll	424	4	that	that	IN
cord-000372-wzwpyvll	424	5	PV	PV	NNP
cord-000372-wzwpyvll	424	6	infection	infection	NN
cord-000372-wzwpyvll	424	7	does	do	VBZ
cord-000372-wzwpyvll	424	8	not	not	RB
cord-000372-wzwpyvll	424	9	affect	affect	VB
cord-000372-wzwpyvll	424	10	distribution	distribution	NN
cord-000372-wzwpyvll	424	11	of	of	IN
cord-000372-wzwpyvll	424	12	the	the	DT
cord-000372-wzwpyvll	424	13	polyadenylated	polyadenylated	JJ
cord-000372-wzwpyvll	424	14	mRNA	mRNA	NNP
cord-000372-wzwpyvll	424	15	bulk	bulk	NN
cord-000372-wzwpyvll	424	16	after	after	IN
cord-000372-wzwpyvll	424	17	3	3	CD
cord-000372-wzwpyvll	424	18	hpi	hpi	NNP
cord-000372-wzwpyvll	424	19	[	[	-LRB-
cord-000372-wzwpyvll	424	20	16	16	CD
cord-000372-wzwpyvll	424	21	]	]	-RRB-
cord-000372-wzwpyvll	424	22	.	.	.
cord-000372-wzwpyvll	425	1	A	a	DT
cord-000372-wzwpyvll	425	2	more	more	RBR
cord-000372-wzwpyvll	425	3	detailed	detailed	JJ
cord-000372-wzwpyvll	425	4	analysis	analysis	NN
cord-000372-wzwpyvll	425	5	revealed	reveal	VBD
cord-000372-wzwpyvll	425	6	that	that	IN
cord-000372-wzwpyvll	425	7	expression	expression	NN
cord-000372-wzwpyvll	425	8	of	of	IN
cord-000372-wzwpyvll	425	9	PV	PV	NNP
cord-000372-wzwpyvll	425	10	2A	2a	CD
cord-000372-wzwpyvll	425	11	pro	pro	JJ
cord-000372-wzwpyvll	425	12	in	in	IN
cord-000372-wzwpyvll	425	13	HeLa	HeLa	NNP
cord-000372-wzwpyvll	425	14	cells	cell	NNS
cord-000372-wzwpyvll	425	15	induces	induce	VBZ
cord-000372-wzwpyvll	425	16	a	a	DT
cord-000372-wzwpyvll	425	17	number	number	NN
cord-000372-wzwpyvll	425	18	of	of	IN
cord-000372-wzwpyvll	425	19	disorders	disorder	NNS
cord-000372-wzwpyvll	425	20	in	in	IN
cord-000372-wzwpyvll	425	21	RNA	RNA	NNP
cord-000372-wzwpyvll	425	22	location	location	NN
cord-000372-wzwpyvll	425	23	.	.	.
cord-000372-wzwpyvll	426	1	Nuclear	nuclear	JJ
cord-000372-wzwpyvll	426	2	export	export	NN
cord-000372-wzwpyvll	426	3	of	of	IN
cord-000372-wzwpyvll	426	4	cellular	cellular	NN
cord-000372-wzwpyvll	426	5	mRNAs	mRNAs	NNPS
cord-000372-wzwpyvll	426	6	is	be	VBZ
cord-000372-wzwpyvll	426	7	inhibited	inhibit	VBN
cord-000372-wzwpyvll	426	8	in	in	IN
cord-000372-wzwpyvll	426	9	2A	2a	CD
cord-000372-wzwpyvll	426	10	pro	pro	JJ
cord-000372-wzwpyvll	426	11	-expressing	-expressing	NN
cord-000372-wzwpyvll	426	12	cells	cell	NNS
cord-000372-wzwpyvll	426	13	in	in	IN
cord-000372-wzwpyvll	426	14	a	a	DT
cord-000372-wzwpyvll	426	15	dose	dose	NN
cord-000372-wzwpyvll	426	16	dependent	dependent	JJ
cord-000372-wzwpyvll	426	17	manner	manner	NN
cord-000372-wzwpyvll	426	18	concomitantly	concomitantly	RB
cord-000372-wzwpyvll	426	19	with	with	IN
cord-000372-wzwpyvll	426	20	Nup98	Nup98	NNP
cord-000372-wzwpyvll	426	21	,	,	,
cord-000372-wzwpyvll	426	22	Nup62	Nup62	NNP
cord-000372-wzwpyvll	426	23	and	and	CC
cord-000372-wzwpyvll	426	24	Nup153	Nup153	NFP
cord-000372-wzwpyvll	426	25	cleavage	cleavage	NN
cord-000372-wzwpyvll	426	26	[	[	-LRB-
cord-000372-wzwpyvll	426	27	17	17	CD
cord-000372-wzwpyvll	426	28	]	]	-RRB-
cord-000372-wzwpyvll	426	29	.	.	.
cord-000372-wzwpyvll	427	1	Interestingly	interestingly	RB
cord-000372-wzwpyvll	427	2	,	,	,
cord-000372-wzwpyvll	427	3	mRNA	mrna	NN
cord-000372-wzwpyvll	427	4	export	export	NN
cord-000372-wzwpyvll	427	5	of	of	IN
cord-000372-wzwpyvll	427	6	constitutively	constitutively	RB
cord-000372-wzwpyvll	427	7	expressed	express	VBN
cord-000372-wzwpyvll	427	8	mRNAs	mrna	NNS
cord-000372-wzwpyvll	427	9	such	such	JJ
cord-000372-wzwpyvll	427	10	as	as	IN
cord-000372-wzwpyvll	427	11	β	β	NN
cord-000372-wzwpyvll	427	12	-	-	HYPH
cord-000372-wzwpyvll	427	13	actin	actin	NNP
cord-000372-wzwpyvll	427	14	is	be	VBZ
cord-000372-wzwpyvll	427	15	less	less	RBR
cord-000372-wzwpyvll	427	16	affected	affected	JJ
cord-000372-wzwpyvll	427	17	than	than	IN
cord-000372-wzwpyvll	427	18	that	that	DT
cord-000372-wzwpyvll	427	19	of	of	IN
cord-000372-wzwpyvll	427	20	newly	newly	RB
cord-000372-wzwpyvll	427	21	synthesized	synthesize	VBN
cord-000372-wzwpyvll	427	22	mRNAs	mRNAs	''
cord-000372-wzwpyvll	427	23	.	.	.
cord-000372-wzwpyvll	428	1	For	for	IN
cord-000372-wzwpyvll	428	2	example	example	NN
cord-000372-wzwpyvll	428	3	,	,	,
cord-000372-wzwpyvll	428	4	tetracycline	tetracycline	NN
cord-000372-wzwpyvll	428	5	-	-	HYPH
cord-000372-wzwpyvll	428	6	induced	induce	VBN
cord-000372-wzwpyvll	428	7	luciferase	luciferase	NN
cord-000372-wzwpyvll	428	8	mRNA	mrna	NN
cord-000372-wzwpyvll	428	9	was	be	VBD
cord-000372-wzwpyvll	428	10	almost	almost	RB
cord-000372-wzwpyvll	428	11	totally	totally	RB
cord-000372-wzwpyvll	428	12	retained	retain	VBN
cord-000372-wzwpyvll	428	13	in	in	IN
cord-000372-wzwpyvll	428	14	the	the	DT
cord-000372-wzwpyvll	428	15	nucleus	nucleus	NN
cord-000372-wzwpyvll	428	16	when	when	WRB
cord-000372-wzwpyvll	428	17	these	these	DT
cord-000372-wzwpyvll	428	18	Nups	Nups	NNPS
cord-000372-wzwpyvll	428	19	are	be	VBP
cord-000372-wzwpyvll	428	20	cleaved	cleave	VBN
cord-000372-wzwpyvll	428	21	by	by	IN
cord-000372-wzwpyvll	428	22	PV	PV	NNP
cord-000372-wzwpyvll	428	23	2A	2a	CD
cord-000372-wzwpyvll	428	24	pro	pro	NNP
cord-000372-wzwpyvll	428	25	.	.	.
cord-000372-wzwpyvll	429	1	This	this	DT
cord-000372-wzwpyvll	429	2	effect	effect	NN
cord-000372-wzwpyvll	429	3	was	be	VBD
cord-000372-wzwpyvll	429	4	also	also	RB
cord-000372-wzwpyvll	429	5	observed	observe	VBN
cord-000372-wzwpyvll	429	6	for	for	IN
cord-000372-wzwpyvll	429	7	endogenous	endogenous	JJ
cord-000372-wzwpyvll	429	8	mRNAs	mrna	NNS
cord-000372-wzwpyvll	429	9	such	such	JJ
cord-000372-wzwpyvll	429	10	as	as	IN
cord-000372-wzwpyvll	429	11	IL-6	IL-6	NNP
cord-000372-wzwpyvll	429	12	,	,	,
cord-000372-wzwpyvll	429	13	c	c	NNP
cord-000372-wzwpyvll	429	14	-	-	HYPH
cord-000372-wzwpyvll	429	15	myc	myc	NNP
cord-000372-wzwpyvll	429	16	or	or	CC
cord-000372-wzwpyvll	429	17	p53	p53	NN
cord-000372-wzwpyvll	429	18	mRNAs	mrna	NNS
cord-000372-wzwpyvll	429	19	which	which	WDT
cord-000372-wzwpyvll	429	20	are	be	VBP
cord-000372-wzwpyvll	429	21	induced	induce	VBN
cord-000372-wzwpyvll	429	22	on	on	IN
cord-000372-wzwpyvll	429	23	PV	PV	NNP
cord-000372-wzwpyvll	429	24	2A	2a	CD
cord-000372-wzwpyvll	429	25	pro	pro	JJ
cord-000372-wzwpyvll	429	26	expression	expression	NN
cord-000372-wzwpyvll	429	27	.	.	.
cord-000372-wzwpyvll	430	1	Therefore	therefore	RB
cord-000372-wzwpyvll	430	2	,	,	,
cord-000372-wzwpyvll	430	3	PV	PV	NNP
cord-000372-wzwpyvll	430	4	2A	2a	NN
cord-000372-wzwpyvll	430	5	pro	pro	NNP
cord-000372-wzwpyvll	430	6	could	could	MD
cord-000372-wzwpyvll	430	7	counteract	counteract	VB
cord-000372-wzwpyvll	430	8	the	the	DT
cord-000372-wzwpyvll	430	9	induction	induction	NN
cord-000372-wzwpyvll	430	10	of	of	IN
cord-000372-wzwpyvll	430	11	proapoptotic	proapoptotic	NNP
cord-000372-wzwpyvll	430	12	(	(	-LRB-
cord-000372-wzwpyvll	430	13	c	c	NNP
cord-000372-wzwpyvll	430	14	-	-	HYPH
cord-000372-wzwpyvll	430	15	myc	myc	NNP
cord-000372-wzwpyvll	430	16	and	and	CC
cord-000372-wzwpyvll	430	17	p53	p53	NN
cord-000372-wzwpyvll	430	18	)	)	-RRB-
cord-000372-wzwpyvll	430	19	and	and	CC
cord-000372-wzwpyvll	430	20	proinflammatory	proinflammatory	JJ
cord-000372-wzwpyvll	430	21	(	(	-LRB-
cord-000372-wzwpyvll	430	22	IL-6	IL-6	NNP
cord-000372-wzwpyvll	430	23	)	)	-RRB-
cord-000372-wzwpyvll	430	24	responses	response	NNS
cord-000372-wzwpyvll	430	25	by	by	IN
cord-000372-wzwpyvll	430	26	accumulating	accumulate	VBG
cord-000372-wzwpyvll	430	27	the	the	DT
cord-000372-wzwpyvll	430	28	c	c	NNP
cord-000372-wzwpyvll	430	29	-	-	HYPH
cord-000372-wzwpyvll	430	30	myc	myc	NNP
cord-000372-wzwpyvll	430	31	,	,	,
cord-000372-wzwpyvll	430	32	p53	p53	NN
cord-000372-wzwpyvll	430	33	and	and	CC
cord-000372-wzwpyvll	430	34	IL-6	IL-6	NNP
cord-000372-wzwpyvll	430	35	mRNAs	mRNAs	NNPS
cord-000372-wzwpyvll	430	36	in	in	IN
cord-000372-wzwpyvll	430	37	the	the	DT
cord-000372-wzwpyvll	430	38	nucleus	nucleus	NN
cord-000372-wzwpyvll	430	39	[	[	-LRB-
cord-000372-wzwpyvll	430	40	17	17	CD
cord-000372-wzwpyvll	430	41	]	]	-RRB-
cord-000372-wzwpyvll	430	42	.	.	.
cord-000372-wzwpyvll	431	1	This	this	DT
cord-000372-wzwpyvll	431	2	export	export	NN
cord-000372-wzwpyvll	431	3	blockage	blockage	NN
cord-000372-wzwpyvll	431	4	may	may	MD
cord-000372-wzwpyvll	431	5	prevent	prevent	VB
cord-000372-wzwpyvll	431	6	the	the	DT
cord-000372-wzwpyvll	431	7	establishment	establishment	NN
cord-000372-wzwpyvll	431	8	of	of	IN
cord-000372-wzwpyvll	431	9	a	a	DT
cord-000372-wzwpyvll	431	10	hostcell	hostcell	JJ
cord-000372-wzwpyvll	431	11	response	response	NN
cord-000372-wzwpyvll	431	12	against	against	IN
cord-000372-wzwpyvll	431	13	PV	pv	NN
cord-000372-wzwpyvll	431	14	infection	infection	NN
cord-000372-wzwpyvll	431	15	.	.	.
cord-000372-wzwpyvll	432	1	These	these	DT
cord-000372-wzwpyvll	432	2	findings	finding	NNS
cord-000372-wzwpyvll	432	3	could	could	MD
cord-000372-wzwpyvll	432	4	explain	explain	VB
cord-000372-wzwpyvll	432	5	why	why	WRB
cord-000372-wzwpyvll	432	6	PV	PV	NNP
cord-000372-wzwpyvll	432	7	2A	2a	NN
cord-000372-wzwpyvll	432	8	pro	pro	NNP
cord-000372-wzwpyvll	432	9	is	be	VBZ
cord-000372-wzwpyvll	432	10	essential	essential	JJ
cord-000372-wzwpyvll	432	11	for	for	IN
cord-000372-wzwpyvll	432	12	replication	replication	NN
cord-000372-wzwpyvll	432	13	of	of	IN
cord-000372-wzwpyvll	432	14	PV	pv	NN
cord-000372-wzwpyvll	432	15	in	in	IN
cord-000372-wzwpyvll	432	16	cells	cell	NNS
cord-000372-wzwpyvll	432	17	pre	pre	VBP
cord-000372-wzwpyvll	432	18	-	-	VBN
cord-000372-wzwpyvll	432	19	treated	treat	VBN
cord-000372-wzwpyvll	432	20	with	with	IN
cord-000372-wzwpyvll	432	21	IFN	IFN	NNP
cord-000372-wzwpyvll	432	22	-	-	HYPH
cord-000372-wzwpyvll	432	23	α	α	NNP
cord-000372-wzwpyvll	432	24	[	[	-LRB-
cord-000372-wzwpyvll	432	25	79	79	CD
cord-000372-wzwpyvll	432	26	]	]	-RRB-
cord-000372-wzwpyvll	432	27	.	.	.
cord-000372-wzwpyvll	433	1	Furthermore	furthermore	RB
cord-000372-wzwpyvll	433	2	,	,	,
cord-000372-wzwpyvll	433	3	impairment	impairment	NN
cord-000372-wzwpyvll	433	4	of	of	IN
cord-000372-wzwpyvll	433	5	mRNA	mRNA	NNP
cord-000372-wzwpyvll	433	6	export	export	NN
cord-000372-wzwpyvll	433	7	strongly	strongly	RB
cord-000372-wzwpyvll	433	8	alters	alter	VBZ
cord-000372-wzwpyvll	433	9	the	the	DT
cord-000372-wzwpyvll	433	10	localization	localization	NN
cord-000372-wzwpyvll	433	11	of	of	IN
cord-000372-wzwpyvll	433	12	mRNAs	mRNAs	NNPS
cord-000372-wzwpyvll	433	13	with	with	IN
cord-000372-wzwpyvll	433	14	high	high	JJ
cord-000372-wzwpyvll	433	15	turnover	turnover	NN
cord-000372-wzwpyvll	433	16	as	as	IN
cord-000372-wzwpyvll	433	17	compared	compare	VBN
cord-000372-wzwpyvll	433	18	to	to	IN
cord-000372-wzwpyvll	433	19	constitutively	constitutively	RB
cord-000372-wzwpyvll	433	20	expressed	express	VBN
cord-000372-wzwpyvll	433	21	and	and	CC
cord-000372-wzwpyvll	433	22	highly	highly	RB
cord-000372-wzwpyvll	433	23	stable	stable	JJ
cord-000372-wzwpyvll	433	24	mRNAs	mrna	NNS
cord-000372-wzwpyvll	433	25	such	such	JJ
cord-000372-wzwpyvll	433	26	as	as	IN
cord-000372-wzwpyvll	433	27	β	β	NNP
cord-000372-wzwpyvll	433	28	-	-	:
cord-000372-wzwpyvll	433	29	Actin	Actin	NNP
cord-000372-wzwpyvll	433	30	[	[	-LRB-
cord-000372-wzwpyvll	433	31	17	17	CD
cord-000372-wzwpyvll	433	32	]	]	-RRB-
cord-000372-wzwpyvll	433	33	.	.	.
cord-000372-wzwpyvll	434	1	As	as	IN
cord-000372-wzwpyvll	434	2	observed	observe	VBN
cord-000372-wzwpyvll	434	3	in	in	IN
cord-000372-wzwpyvll	434	4	PV	pv	NN
cord-000372-wzwpyvll	434	5	-	-	HYPH
cord-000372-wzwpyvll	434	6	infected	infect	VBN
cord-000372-wzwpyvll	434	7	cells	cell	NNS
cord-000372-wzwpyvll	434	8	,	,	,
cord-000372-wzwpyvll	434	9	oligo	oligo	NNP
cord-000372-wzwpyvll	434	10	d(T	d(T	NNP
cord-000372-wzwpyvll	434	11	)	)	-RRB-
cord-000372-wzwpyvll	434	12	hybridization	hybridization	NN
cord-000372-wzwpyvll	434	13	revealed	reveal	VBD
cord-000372-wzwpyvll	434	14	that	that	IN
cord-000372-wzwpyvll	434	15	PV	PV	NNP
cord-000372-wzwpyvll	434	16	2A	2a	CD
cord-000372-wzwpyvll	434	17	pro	pro	JJ
cord-000372-wzwpyvll	434	18	expression	expression	NN
cord-000372-wzwpyvll	434	19	hardly	hardly	RB
cord-000372-wzwpyvll	434	20	affects	affect	VBZ
cord-000372-wzwpyvll	434	21	the	the	DT
cord-000372-wzwpyvll	434	22	distribution	distribution	NN
cord-000372-wzwpyvll	434	23	of	of	IN
cord-000372-wzwpyvll	434	24	the	the	DT
cord-000372-wzwpyvll	434	25	polyadenylated	polyadenylated	JJ
cord-000372-wzwpyvll	434	26	mRNA	mRNA	NNP
cord-000372-wzwpyvll	434	27	pool	pool	NN
cord-000372-wzwpyvll	434	28	after	after	IN
cord-000372-wzwpyvll	434	29	short	short	JJ
cord-000372-wzwpyvll	434	30	times	time	NNS
cord-000372-wzwpyvll	434	31	of	of	IN
cord-000372-wzwpyvll	434	32	expression	expression	NN
cord-000372-wzwpyvll	434	33	(	(	-LRB-
cord-000372-wzwpyvll	434	34	8	8	CD
cord-000372-wzwpyvll	434	35	h	h	NN
cord-000372-wzwpyvll	434	36	)	)	-RRB-
cord-000372-wzwpyvll	434	37	.	.	.
cord-000372-wzwpyvll	435	1	However	however	RB
cord-000372-wzwpyvll	435	2	,	,	,
cord-000372-wzwpyvll	435	3	nuclear	nuclear	JJ
cord-000372-wzwpyvll	435	4	accumulation	accumulation	NN
cord-000372-wzwpyvll	435	5	of	of	IN
cord-000372-wzwpyvll	435	6	polyadenylated	polyadenylated	JJ
cord-000372-wzwpyvll	435	7	mRNA	mRNA	NNP
cord-000372-wzwpyvll	435	8	bulk	bulk	NN
cord-000372-wzwpyvll	435	9	is	be	VBZ
cord-000372-wzwpyvll	435	10	detected	detect	VBN
cord-000372-wzwpyvll	435	11	when	when	WRB
cord-000372-wzwpyvll	435	12	cells	cell	NNS
cord-000372-wzwpyvll	435	13	are	be	VBP
cord-000372-wzwpyvll	435	14	exposed	expose	VBN
cord-000372-wzwpyvll	435	15	to	to	IN
cord-000372-wzwpyvll	435	16	PV	PV	NNP
cord-000372-wzwpyvll	435	17	2A	2a	CD
cord-000372-wzwpyvll	435	18	pro	pro	NN
cord-000372-wzwpyvll	435	19	for	for	IN
cord-000372-wzwpyvll	435	20	longer	long	JJR
cord-000372-wzwpyvll	435	21	times	time	NNS
cord-000372-wzwpyvll	435	22	(	(	-LRB-
cord-000372-wzwpyvll	435	23	16	16	CD
cord-000372-wzwpyvll	435	24	and	and	CC
cord-000372-wzwpyvll	435	25	24	24	CD
cord-000372-wzwpyvll	435	26	h	h	NN
cord-000372-wzwpyvll	435	27	)	)	-RRB-
cord-000372-wzwpyvll	435	28	.	.	.
cord-000372-wzwpyvll	436	1	In	in	IN
cord-000372-wzwpyvll	436	2	this	this	DT
cord-000372-wzwpyvll	436	3	regard	regard	NN
cord-000372-wzwpyvll	436	4	,	,	,
cord-000372-wzwpyvll	436	5	the	the	DT
cord-000372-wzwpyvll	436	6	progression	progression	NN
cord-000372-wzwpyvll	436	7	of	of	IN
cord-000372-wzwpyvll	436	8	the	the	DT
cord-000372-wzwpyvll	436	9	alterations	alteration	NNS
cord-000372-wzwpyvll	436	10	of	of	IN
cord-000372-wzwpyvll	436	11	polyadenylated	polyadenylated	JJ
cord-000372-wzwpyvll	436	12	mRNA	mRNA	NNP
cord-000372-wzwpyvll	436	13	localization	localization	NN
cord-000372-wzwpyvll	436	14	in	in	IN
cord-000372-wzwpyvll	436	15	2A	2a	CD
cord-000372-wzwpyvll	436	16	pro	pro	JJ
cord-000372-wzwpyvll	436	17	-expressing	-expressing	NN
cord-000372-wzwpyvll	436	18	cells	cell	NNS
cord-000372-wzwpyvll	436	19	takes	take	VBZ
cord-000372-wzwpyvll	436	20	place	place	NN
cord-000372-wzwpyvll	436	21	as	as	IN
cord-000372-wzwpyvll	436	22	follows	follow	VBZ
cord-000372-wzwpyvll	436	23	:	:	:
cord-000372-wzwpyvll	436	24	(	(	-LRB-
cord-000372-wzwpyvll	436	25	i	i	NN
cord-000372-wzwpyvll	436	26	)	)	-RRB-
cord-000372-wzwpyvll	436	27	disruption	disruption	NN
cord-000372-wzwpyvll	436	28	of	of	IN
cord-000372-wzwpyvll	436	29	nuclear	nuclear	JJ
cord-000372-wzwpyvll	436	30	mRNA	mrna	NN
cord-000372-wzwpyvll	436	31	-	-	HYPH
cord-000372-wzwpyvll	436	32	containing	contain	VBG
cord-000372-wzwpyvll	436	33	foci	foci	NN
cord-000372-wzwpyvll	436	34	(	(	-LRB-
cord-000372-wzwpyvll	436	35	ii	ii	NN
cord-000372-wzwpyvll	436	36	)	)	-RRB-
cord-000372-wzwpyvll	436	37	appearance	appearance	NN
cord-000372-wzwpyvll	436	38	of	of	IN
cord-000372-wzwpyvll	436	39	mRNAcontaining	mrnacontaine	VBG
cord-000372-wzwpyvll	436	40	granules	granule	NNS
cord-000372-wzwpyvll	436	41	in	in	IN
cord-000372-wzwpyvll	436	42	the	the	DT
cord-000372-wzwpyvll	436	43	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	436	44	(	(	-LRB-
cord-000372-wzwpyvll	436	45	most	most	RBS
cord-000372-wzwpyvll	436	46	probably	probably	RB
cord-000372-wzwpyvll	436	47	stress	stress	NN
cord-000372-wzwpyvll	436	48	granules	granule	NNS
cord-000372-wzwpyvll	436	49	)	)	-RRB-
cord-000372-wzwpyvll	436	50	and	and	CC
cord-000372-wzwpyvll	436	51	(	(	-LRB-
cord-000372-wzwpyvll	436	52	iii	iii	NN
cord-000372-wzwpyvll	436	53	)	)	-RRB-
cord-000372-wzwpyvll	436	54	depletion	depletion	NN
cord-000372-wzwpyvll	436	55	of	of	IN
cord-000372-wzwpyvll	436	56	cytoplasmic	cytoplasmic	JJ
cord-000372-wzwpyvll	436	57	mRNAs	mrna	NNS
cord-000372-wzwpyvll	436	58	.	.	.
cord-000372-wzwpyvll	437	1	These	these	DT
cord-000372-wzwpyvll	437	2	events	event	NNS
cord-000372-wzwpyvll	437	3	were	be	VBD
cord-000372-wzwpyvll	437	4	more	more	RBR
cord-000372-wzwpyvll	437	5	clearly	clearly	RB
cord-000372-wzwpyvll	437	6	observed	observe	VBN
cord-000372-wzwpyvll	437	7	when	when	WRB
cord-000372-wzwpyvll	437	8	high	high	JJ
cord-000372-wzwpyvll	437	9	amounts	amount	NNS
cord-000372-wzwpyvll	437	10	of	of	IN
cord-000372-wzwpyvll	437	11	PV	PV	NNP
cord-000372-wzwpyvll	437	12	2A	2a	CD
cord-000372-wzwpyvll	437	13	pro	pro	NNP
cord-000372-wzwpyvll	437	14	are	be	VBP
cord-000372-wzwpyvll	437	15	synthesized	synthesize	VBN
cord-000372-wzwpyvll	437	16	,	,	,
cord-000372-wzwpyvll	437	17	reflecting	reflect	VBG
cord-000372-wzwpyvll	437	18	that	that	IN
cord-000372-wzwpyvll	437	19	nuclear	nuclear	JJ
cord-000372-wzwpyvll	437	20	accumulation	accumulation	NN
cord-000372-wzwpyvll	437	21	of	of	IN
cord-000372-wzwpyvll	437	22	mRNAs	mRNAs	NNPS
cord-000372-wzwpyvll	437	23	is	be	VBZ
cord-000372-wzwpyvll	437	24	a	a	DT
cord-000372-wzwpyvll	437	25	time	time	NN
cord-000372-wzwpyvll	437	26	-	-	HYPH
cord-000372-wzwpyvll	437	27	and	and	CC
cord-000372-wzwpyvll	437	28	dose	dose	NN
cord-000372-wzwpyvll	437	29	-	-	HYPH
cord-000372-wzwpyvll	437	30	dependent	dependent	JJ
cord-000372-wzwpyvll	437	31	process	process	NN
cord-000372-wzwpyvll	437	32	[	[	-LRB-
cord-000372-wzwpyvll	437	33	17	17	CD
cord-000372-wzwpyvll	437	34	]	]	-RRB-
cord-000372-wzwpyvll	437	35	.	.	.
cord-000372-wzwpyvll	438	1	Nevertheless	nevertheless	RB
cord-000372-wzwpyvll	438	2	,	,	,
cord-000372-wzwpyvll	438	3	PV	PV	NNP
cord-000372-wzwpyvll	438	4	2A	2a	NN
cord-000372-wzwpyvll	438	5	pro	pro	NNP
cord-000372-wzwpyvll	438	6	is	be	VBZ
cord-000372-wzwpyvll	438	7	not	not	RB
cord-000372-wzwpyvll	438	8	only	only	RB
cord-000372-wzwpyvll	438	9	able	able	JJ
cord-000372-wzwpyvll	438	10	to	to	TO
cord-000372-wzwpyvll	438	11	block	block	VB
cord-000372-wzwpyvll	438	12	mRNA	mRNA	NNP
cord-000372-wzwpyvll	438	13	export	export	NN
cord-000372-wzwpyvll	438	14	,	,	,
cord-000372-wzwpyvll	438	15	but	but	CC
cord-000372-wzwpyvll	438	16	also	also	RB
cord-000372-wzwpyvll	438	17	rRNA	rrna	NN
cord-000372-wzwpyvll	438	18	and	and	CC
cord-000372-wzwpyvll	438	19	snRNA	snrna	NN
cord-000372-wzwpyvll	438	20	transport	transport	NN
cord-000372-wzwpyvll	438	21	.	.	.
cord-000372-wzwpyvll	439	1	Both	both	DT
cord-000372-wzwpyvll	439	2	18S	18S	NNPS
cord-000372-wzwpyvll	439	3	rRNA	rRNA	NNP
cord-000372-wzwpyvll	439	4	and	and	CC
cord-000372-wzwpyvll	439	5	U2	U2	NNP
cord-000372-wzwpyvll	439	6	snRNA	snrna	NN
cord-000372-wzwpyvll	439	7	accumulate	accumulate	NN
cord-000372-wzwpyvll	439	8	in	in	IN
cord-000372-wzwpyvll	439	9	the	the	DT
cord-000372-wzwpyvll	439	10	nucleus	nucleus	NN
cord-000372-wzwpyvll	439	11	of	of	IN
cord-000372-wzwpyvll	439	12	2A	2A	NNP
cord-000372-wzwpyvll	439	13	proexpressing	proexpressing	NN
cord-000372-wzwpyvll	439	14	cells	cell	NNS
cord-000372-wzwpyvll	439	15	in	in	IN
cord-000372-wzwpyvll	439	16	a	a	DT
cord-000372-wzwpyvll	439	17	dose	dose	NN
cord-000372-wzwpyvll	439	18	-	-	HYPH
cord-000372-wzwpyvll	439	19	dependent	dependent	JJ
cord-000372-wzwpyvll	439	20	manner	manner	NN
cord-000372-wzwpyvll	439	21	.	.	.
cord-000372-wzwpyvll	440	1	Most	most	RBS
cord-000372-wzwpyvll	440	2	probably	probably	RB
cord-000372-wzwpyvll	440	3	,	,	,
cord-000372-wzwpyvll	440	4	cleavage	cleavage	NN
cord-000372-wzwpyvll	440	5	of	of	IN
cord-000372-wzwpyvll	440	6	Nup98	Nup98	NNP
cord-000372-wzwpyvll	440	7	,	,	,
cord-000372-wzwpyvll	440	8	Nup62	Nup62	NNP
cord-000372-wzwpyvll	441	1	and	and	CC
cord-000372-wzwpyvll	441	2	Nup153	nup153	CD
cord-000372-wzwpyvll	441	3	is	be	VBZ
cord-000372-wzwpyvll	441	4	involved	involve	VBN
cord-000372-wzwpyvll	441	5	in	in	IN
cord-000372-wzwpyvll	441	6	these	these	DT
cord-000372-wzwpyvll	441	7	effects	effect	NNS
cord-000372-wzwpyvll	441	8	,	,	,
cord-000372-wzwpyvll	441	9	since	since	IN
cord-000372-wzwpyvll	441	10	rRNA	rRNA	NNP
cord-000372-wzwpyvll	441	11	,	,	,
cord-000372-wzwpyvll	441	12	snRNA	snRNA	NNP
cord-000372-wzwpyvll	441	13	,	,	,
cord-000372-wzwpyvll	441	14	and	and	CC
cord-000372-wzwpyvll	441	15	mRNA	mRNA	NNP
cord-000372-wzwpyvll	441	16	are	be	VBP
cord-000372-wzwpyvll	441	17	exported	export	VBN
cord-000372-wzwpyvll	441	18	using	use	VBG
cord-000372-wzwpyvll	441	19	different	different	JJ
cord-000372-wzwpyvll	441	20	cargo	cargo	NN
cord-000372-wzwpyvll	441	21	receptors	receptor	NNS
cord-000372-wzwpyvll	441	22	and	and	CC
cord-000372-wzwpyvll	441	23	auxiliary	auxiliary	JJ
cord-000372-wzwpyvll	441	24	proteins	protein	NNS
cord-000372-wzwpyvll	441	25	(	(	-LRB-
cord-000372-wzwpyvll	441	26	see	see	VB
cord-000372-wzwpyvll	441	27	above	above	RB
cord-000372-wzwpyvll	441	28	)	)	-RRB-
cord-000372-wzwpyvll	441	29	but	but	CC
cord-000372-wzwpyvll	441	30	all	all	DT
cord-000372-wzwpyvll	441	31	of	of	IN
cord-000372-wzwpyvll	441	32	them	-PRON-	PRP
cord-000372-wzwpyvll	441	33	relay	relay	VBP
cord-000372-wzwpyvll	441	34	in	in	IN
cord-000372-wzwpyvll	441	35	Nup	Nup	NNP
cord-000372-wzwpyvll	441	36	activity	activity	NN
cord-000372-wzwpyvll	441	37	to	to	TO
cord-000372-wzwpyvll	441	38	traverse	traverse	VB
cord-000372-wzwpyvll	441	39	NPC	NPC	NNP
cord-000372-wzwpyvll	441	40	[	[	-LRB-
cord-000372-wzwpyvll	441	41	163	163	CD
cord-000372-wzwpyvll	441	42	]	]	-RRB-
cord-000372-wzwpyvll	441	43	.	.	.
cord-000372-wzwpyvll	442	1	Importantly	importantly	RB
cord-000372-wzwpyvll	442	2	,	,	,
cord-000372-wzwpyvll	442	3	tRNAs	trnas	ADD
cord-000372-wzwpyvll	442	4	(	(	-LRB-
cord-000372-wzwpyvll	442	5	val	val	NNP
cord-000372-wzwpyvll	442	6	-	-	HYPH
cord-000372-wzwpyvll	442	7	tRNA	tRNA	NNP
cord-000372-wzwpyvll	442	8	)	)	-RRB-
cord-000372-wzwpyvll	442	9	are	be	VBP
cord-000372-wzwpyvll	442	10	exported	export	VBN
cord-000372-wzwpyvll	442	11	normally	normally	RB
cord-000372-wzwpyvll	442	12	despite	despite	IN
cord-000372-wzwpyvll	442	13	PV	PV	NNP
cord-000372-wzwpyvll	442	14	2A	2a	CD
cord-000372-wzwpyvll	442	15	pro	pro	JJ
cord-000372-wzwpyvll	442	16	expression	expression	NN
cord-000372-wzwpyvll	442	17	,	,	,
cord-000372-wzwpyvll	442	18	indicating	indicate	VBG
cord-000372-wzwpyvll	442	19	that	that	IN
cord-000372-wzwpyvll	442	20	some	some	DT
cord-000372-wzwpyvll	442	21	RNA	RNA	NNP
cord-000372-wzwpyvll	442	22	nuclear	nuclear	JJ
cord-000372-wzwpyvll	442	23	export	export	NN
cord-000372-wzwpyvll	442	24	pathways	pathway	NNS
cord-000372-wzwpyvll	442	25	are	be	VBP
cord-000372-wzwpyvll	442	26	not	not	RB
cord-000372-wzwpyvll	442	27	affected	affect	VBN
cord-000372-wzwpyvll	442	28	by	by	IN
cord-000372-wzwpyvll	442	29	this	this	DT
cord-000372-wzwpyvll	442	30	viral	viral	JJ
cord-000372-wzwpyvll	442	31	protease	protease	NN
cord-000372-wzwpyvll	442	32	.	.	.
cord-000372-wzwpyvll	443	1	In	in	IN
cord-000372-wzwpyvll	443	2	fact	fact	NN
cord-000372-wzwpyvll	443	3	,	,	,
cord-000372-wzwpyvll	443	4	Nup98	Nup98	NNP
cord-000372-wzwpyvll	443	5	,	,	,
cord-000372-wzwpyvll	443	6	Nup62	Nup62	NNP
cord-000372-wzwpyvll	443	7	,	,	,
cord-000372-wzwpyvll	443	8	and	and	CC
cord-000372-wzwpyvll	443	9	Nup153	Nup153	.
cord-000372-wzwpyvll	444	1	are	be	VBP
cord-000372-wzwpyvll	444	2	not	not	RB
cord-000372-wzwpyvll	444	3	directly	directly	RB
cord-000372-wzwpyvll	444	4	involved	involve	VBN
cord-000372-wzwpyvll	444	5	in	in	IN
cord-000372-wzwpyvll	444	6	tRNA	trna	NN
cord-000372-wzwpyvll	444	7	export	export	NN
cord-000372-wzwpyvll	444	8	[	[	-LRB-
cord-000372-wzwpyvll	444	9	163	163	CD
cord-000372-wzwpyvll	444	10	]	]	-RRB-
cord-000372-wzwpyvll	444	11	,	,	,
cord-000372-wzwpyvll	444	12	reinforcing	reinforce	VBG
cord-000372-wzwpyvll	444	13	the	the	DT
cord-000372-wzwpyvll	444	14	idea	idea	NN
cord-000372-wzwpyvll	444	15	that	that	IN
cord-000372-wzwpyvll	444	16	nucleoporin	nucleoporin	NNP
cord-000372-wzwpyvll	444	17	cleavage	cleavage	NN
cord-000372-wzwpyvll	444	18	plays	play	VBZ
cord-000372-wzwpyvll	444	19	a	a	DT
cord-000372-wzwpyvll	444	20	central	central	JJ
cord-000372-wzwpyvll	444	21	role	role	NN
cord-000372-wzwpyvll	444	22	in	in	IN
cord-000372-wzwpyvll	444	23	the	the	DT
cord-000372-wzwpyvll	444	24	impairment	impairment	NN
cord-000372-wzwpyvll	444	25	of	of	IN
cord-000372-wzwpyvll	444	26	protein	protein	NN
cord-000372-wzwpyvll	444	27	and	and	CC
cord-000372-wzwpyvll	444	28	RNA	RNA	NNP
cord-000372-wzwpyvll	444	29	trafficking	trafficking	NN
cord-000372-wzwpyvll	444	30	by	by	IN
cord-000372-wzwpyvll	444	31	PV	PV	NNP
cord-000372-wzwpyvll	444	32	(	(	-LRB-
cord-000372-wzwpyvll	444	33	Figure	Figure	NNP
cord-000372-wzwpyvll	444	34	4	4	CD
cord-000372-wzwpyvll	444	35	)	)	-RRB-
cord-000372-wzwpyvll	444	36	.	.	.
cord-000372-wzwpyvll	445	1	Notably	notably	RB
cord-000372-wzwpyvll	445	2	,	,	,
cord-000372-wzwpyvll	445	3	IFN	IFN	NNP
cord-000372-wzwpyvll	445	4	-	-	HYPH
cord-000372-wzwpyvll	445	5	γ	γ	NNP
cord-000372-wzwpyvll	445	6	induced	induce	VBD
cord-000372-wzwpyvll	445	7	a	a	DT
cord-000372-wzwpyvll	445	8	specific	specific	JJ
cord-000372-wzwpyvll	445	9	increase	increase	NN
cord-000372-wzwpyvll	445	10	of	of	IN
cord-000372-wzwpyvll	445	11	Nup98	Nup98	NNP
cord-000372-wzwpyvll	445	12	levels	level	NNS
cord-000372-wzwpyvll	445	13	in	in	IN
cord-000372-wzwpyvll	445	14	HeLa	HeLa	NNP
cord-000372-wzwpyvll	445	15	cells	cell	NNS
cord-000372-wzwpyvll	445	16	that	that	WDT
cord-000372-wzwpyvll	445	17	counteracts	counteract	VBZ
cord-000372-wzwpyvll	445	18	the	the	DT
cord-000372-wzwpyvll	445	19	inhibition	inhibition	NN
cord-000372-wzwpyvll	445	20	of	of	IN
cord-000372-wzwpyvll	445	21	mRNA	mRNA	NNP
cord-000372-wzwpyvll	445	22	export	export	NN
cord-000372-wzwpyvll	445	23	by	by	IN
cord-000372-wzwpyvll	445	24	PV	PV	NNP
cord-000372-wzwpyvll	445	25	2A	2a	CD
cord-000372-wzwpyvll	445	26	pro	pro	NNP
cord-000372-wzwpyvll	445	27	[	[	-LRB-
cord-000372-wzwpyvll	445	28	17	17	CD
cord-000372-wzwpyvll	445	29	,	,	,
cord-000372-wzwpyvll	445	30	201	201	CD
cord-000372-wzwpyvll	445	31	]	]	-RRB-
cord-000372-wzwpyvll	445	32	.	.	.
cord-000372-wzwpyvll	446	1	Collectively	collectively	RB
cord-000372-wzwpyvll	446	2	,	,	,
cord-000372-wzwpyvll	446	3	these	these	DT
cord-000372-wzwpyvll	446	4	findings	finding	NNS
cord-000372-wzwpyvll	446	5	reflect	reflect	VBP
cord-000372-wzwpyvll	446	6	the	the	DT
cord-000372-wzwpyvll	446	7	central	central	JJ
cord-000372-wzwpyvll	446	8	role	role	NN
cord-000372-wzwpyvll	446	9	of	of	IN
cord-000372-wzwpyvll	446	10	Nup98	Nup98	NNP
cord-000372-wzwpyvll	446	11	in	in	IN
cord-000372-wzwpyvll	446	12	PV	PV	NNP
cord-000372-wzwpyvll	446	13	infection	infection	NN
cord-000372-wzwpyvll	446	14	and	and	CC
cord-000372-wzwpyvll	446	15	in	in	IN
cord-000372-wzwpyvll	446	16	antiviral	antiviral	JJ
cord-000372-wzwpyvll	446	17	response	response	NN
cord-000372-wzwpyvll	446	18	,	,	,
cord-000372-wzwpyvll	446	19	since	since	IN
cord-000372-wzwpyvll	446	20	its	-PRON-	PRP$
cord-000372-wzwpyvll	446	21	overexpression	overexpression	NN
cord-000372-wzwpyvll	446	22	by	by	IN
cord-000372-wzwpyvll	446	23	itself	-PRON-	PRP
cord-000372-wzwpyvll	446	24	prevents	prevent	VBZ
cord-000372-wzwpyvll	446	25	,	,	,
cord-000372-wzwpyvll	446	26	at	at	IN
cord-000372-wzwpyvll	446	27	least	least	JJS
cord-000372-wzwpyvll	446	28	in	in	IN
cord-000372-wzwpyvll	446	29	part	part	NN
cord-000372-wzwpyvll	446	30	,	,	,
cord-000372-wzwpyvll	446	31	blockade	blockade	NN
cord-000372-wzwpyvll	446	32	of	of	IN
cord-000372-wzwpyvll	446	33	nuclear	nuclear	JJ
cord-000372-wzwpyvll	446	34	RNA	RNA	NNP
cord-000372-wzwpyvll	446	35	export	export	NN
cord-000372-wzwpyvll	446	36	.	.	.
cord-000372-wzwpyvll	447	1	Therefore	therefore	RB
cord-000372-wzwpyvll	447	2	,	,	,
cord-000372-wzwpyvll	447	3	secretion	secretion	NN
cord-000372-wzwpyvll	447	4	of	of	IN
cord-000372-wzwpyvll	447	5	IFN	IFN	NNP
cord-000372-wzwpyvll	447	6	-	-	HYPH
cord-000372-wzwpyvll	447	7	γ	γ	NNP
cord-000372-wzwpyvll	447	8	by	by	IN
cord-000372-wzwpyvll	447	9	immune	immune	JJ
cord-000372-wzwpyvll	447	10	cells	cell	NNS
cord-000372-wzwpyvll	447	11	might	may	MD
cord-000372-wzwpyvll	447	12	allow	allow	VB
cord-000372-wzwpyvll	447	13	the	the	DT
cord-000372-wzwpyvll	447	14	induction	induction	NN
cord-000372-wzwpyvll	447	15	of	of	IN
cord-000372-wzwpyvll	447	16	antiviral	antiviral	JJ
cord-000372-wzwpyvll	447	17	response	response	NN
cord-000372-wzwpyvll	447	18	by	by	IN
cord-000372-wzwpyvll	447	19	neighbouring	neighbouring	NN
cord-000372-wzwpyvll	447	20	cells	cell	NNS
cord-000372-wzwpyvll	447	21	by	by	IN
cord-000372-wzwpyvll	447	22	increasing	increase	VBG
cord-000372-wzwpyvll	447	23	the	the	DT
cord-000372-wzwpyvll	447	24	levels	level	NNS
cord-000372-wzwpyvll	447	25	of	of	IN
cord-000372-wzwpyvll	447	26	Nup98	Nup98	NNP
cord-000372-wzwpyvll	447	27	in	in	IN
cord-000372-wzwpyvll	447	28	order	order	NN
cord-000372-wzwpyvll	447	29	to	to	TO
cord-000372-wzwpyvll	447	30	protect	protect	VB
cord-000372-wzwpyvll	447	31	nuclearcytoplasmic	nuclearcytoplasmic	JJ
cord-000372-wzwpyvll	447	32	protein	protein	NN
cord-000372-wzwpyvll	447	33	and	and	CC
cord-000372-wzwpyvll	447	34	RNA	RNA	NNP
cord-000372-wzwpyvll	447	35	trafficking	traffic	VBG
cord-000372-wzwpyvll	447	36	pathways	pathway	NNS
cord-000372-wzwpyvll	447	37	.	.	.
cord-000372-wzwpyvll	448	1	The	the	DT
cord-000372-wzwpyvll	448	2	physiological	physiological	JJ
cord-000372-wzwpyvll	448	3	relevance	relevance	NN
cord-000372-wzwpyvll	448	4	of	of	IN
cord-000372-wzwpyvll	448	5	the	the	DT
cord-000372-wzwpyvll	448	6	crosstalk	crosstalk	NN
cord-000372-wzwpyvll	448	7	between	between	IN
cord-000372-wzwpyvll	448	8	Nup98-PV	Nup98-PV	NNP
cord-000372-wzwpyvll	448	9	2A	2a	CD
cord-000372-wzwpyvll	448	10	pro	pro	NN
cord-000372-wzwpyvll	448	11	in	in	IN
cord-000372-wzwpyvll	448	12	PV	PV	NNP
cord-000372-wzwpyvll	448	13	(	(	-LRB-
cord-000372-wzwpyvll	448	14	and	and	CC
cord-000372-wzwpyvll	448	15	other	other	JJ
cord-000372-wzwpyvll	448	16	viruses	virus	NNS
cord-000372-wzwpyvll	448	17	)	)	-RRB-
cord-000372-wzwpyvll	448	18	infection	infection	NN
cord-000372-wzwpyvll	448	19	might	may	MD
cord-000372-wzwpyvll	448	20	be	be	VB
cord-000372-wzwpyvll	448	21	studied	study	VBN
cord-000372-wzwpyvll	448	22	in	in	IN
cord-000372-wzwpyvll	448	23	the	the	DT
cord-000372-wzwpyvll	448	24	future	future	NN
cord-000372-wzwpyvll	448	25	with	with	IN
cord-000372-wzwpyvll	448	26	cellular	cellular	JJ
cord-000372-wzwpyvll	448	27	and	and	CC
cord-000372-wzwpyvll	448	28	animal	animal	NN
cord-000372-wzwpyvll	448	29	systems	system	NNS
cord-000372-wzwpyvll	448	30	.	.	.
cord-000372-wzwpyvll	449	1	That	that	DT
cord-000372-wzwpyvll	449	2	Target	Target	NNP
cord-000372-wzwpyvll	449	3	the	the	DT
cord-000372-wzwpyvll	449	4	Nuclear	Nuclear	NNP
cord-000372-wzwpyvll	449	5	Pore	Pore	NNP
cord-000372-wzwpyvll	449	6	.	.	.
cord-000372-wzwpyvll	450	1	As	as	IN
cord-000372-wzwpyvll	450	2	mentioned	mention	VBN
cord-000372-wzwpyvll	450	3	above	above	RB
cord-000372-wzwpyvll	450	4	,	,	,
cord-000372-wzwpyvll	450	5	HRV	HRV	NNP
cord-000372-wzwpyvll	450	6	also	also	RB
cord-000372-wzwpyvll	450	7	induces	induce	VBZ
cord-000372-wzwpyvll	450	8	cleavage	cleavage	NN
cord-000372-wzwpyvll	450	9	of	of	IN
cord-000372-wzwpyvll	450	10	Nup62	Nup62	NNP
cord-000372-wzwpyvll	450	11	,	,	,
cord-000372-wzwpyvll	450	12	Nup153	Nup153	.
cord-000372-wzwpyvll	451	1	and	and	CC
cord-000372-wzwpyvll	451	2	most	most	RBS
cord-000372-wzwpyvll	451	3	probably	probably	RB
cord-000372-wzwpyvll	451	4	Nup98	Nup98	NNP
cord-000372-wzwpyvll	451	5	,	,	,
cord-000372-wzwpyvll	451	6	leading	lead	VBG
cord-000372-wzwpyvll	451	7	to	to	IN
cord-000372-wzwpyvll	451	8	the	the	DT
cord-000372-wzwpyvll	451	9	impairment	impairment	NN
cord-000372-wzwpyvll	451	10	of	of	IN
cord-000372-wzwpyvll	451	11	nuclear	nuclear	JJ
cord-000372-wzwpyvll	451	12	protein	protein	NN
cord-000372-wzwpyvll	451	13	import	import	NN
cord-000372-wzwpyvll	451	14	[	[	-LRB-
cord-000372-wzwpyvll	451	15	159	159	CD
cord-000372-wzwpyvll	451	16	]	]	-RRB-
cord-000372-wzwpyvll	451	17	.	.	.
cord-000372-wzwpyvll	452	1	Nevertheless	nevertheless	RB
cord-000372-wzwpyvll	452	2	,	,	,
cord-000372-wzwpyvll	452	3	PV	PV	NNP
cord-000372-wzwpyvll	452	4	and	and	CC
cord-000372-wzwpyvll	452	5	HRV	HRV	NNP
cord-000372-wzwpyvll	452	6	2A	2a	CD
cord-000372-wzwpyvll	452	7	pro	pro	NNP
cord-000372-wzwpyvll	452	8	exhibit	exhibit	NN
cord-000372-wzwpyvll	452	9	high	high	JJ
cord-000372-wzwpyvll	452	10	homology	homology	NN
cord-000372-wzwpyvll	452	11	and	and	CC
cord-000372-wzwpyvll	452	12	both	both	DT
cord-000372-wzwpyvll	452	13	proteases	protease	NNS
cord-000372-wzwpyvll	452	14	are	be	VBP
cord-000372-wzwpyvll	452	15	therefore	therefore	RB
cord-000372-wzwpyvll	452	16	expected	expect	VBN
cord-000372-wzwpyvll	452	17	to	to	TO
cord-000372-wzwpyvll	452	18	share	share	VB
cord-000372-wzwpyvll	452	19	common	common	JJ
cord-000372-wzwpyvll	452	20	targets	target	NNS
cord-000372-wzwpyvll	452	21	.	.	.
cord-000372-wzwpyvll	453	1	In	in	IN
cord-000372-wzwpyvll	453	2	contrast	contrast	NN
cord-000372-wzwpyvll	453	3	,	,	,
cord-000372-wzwpyvll	453	4	the	the	DT
cord-000372-wzwpyvll	453	5	2A	2A	NNP
cord-000372-wzwpyvll	453	6	gene	gene	NN
cord-000372-wzwpyvll	453	7	of	of	IN
cord-000372-wzwpyvll	453	8	cardioviruses	cardioviruses	NNP
cord-000372-wzwpyvll	453	9	encodes	encode	VBZ
cord-000372-wzwpyvll	453	10	a	a	DT
cord-000372-wzwpyvll	453	11	short	short	JJ
cord-000372-wzwpyvll	453	12	peptide	peptide	NN
cord-000372-wzwpyvll	453	13	with	with	IN
cord-000372-wzwpyvll	453	14	autoproteolytic	autoproteolytic	JJ
cord-000372-wzwpyvll	453	15	activity	activity	NN
cord-000372-wzwpyvll	453	16	but	but	CC
cord-000372-wzwpyvll	453	17	lacks	lack	VBZ
cord-000372-wzwpyvll	453	18	trans	trans	JJ
cord-000372-wzwpyvll	453	19	-	-	JJ
cord-000372-wzwpyvll	453	20	protease	protease	JJ
cord-000372-wzwpyvll	453	21	activity	activity	NN
cord-000372-wzwpyvll	453	22	.	.	.
cord-000372-wzwpyvll	454	1	However	however	RB
cord-000372-wzwpyvll	454	2	,	,	,
cord-000372-wzwpyvll	454	3	EMCV	EMCV	NNP
cord-000372-wzwpyvll	454	4	and	and	CC
cord-000372-wzwpyvll	454	5	mengovirus	mengovirus	NNP
cord-000372-wzwpyvll	454	6	are	be	VBP
cord-000372-wzwpyvll	454	7	able	able	JJ
cord-000372-wzwpyvll	454	8	to	to	TO
cord-000372-wzwpyvll	454	9	damage	damage	VB
cord-000372-wzwpyvll	454	10	NPC	NPC	NNP
cord-000372-wzwpyvll	454	11	[	[	-LRB-
cord-000372-wzwpyvll	454	12	202	202	CD
cord-000372-wzwpyvll	454	13	]	]	-RRB-
cord-000372-wzwpyvll	454	14	.	.	.
cord-000372-wzwpyvll	455	1	As	as	IN
cord-000372-wzwpyvll	455	2	occurs	occur	VBZ
cord-000372-wzwpyvll	455	3	in	in	IN
cord-000372-wzwpyvll	455	4	PV	pv	NN
cord-000372-wzwpyvll	455	5	-	-	HYPH
cord-000372-wzwpyvll	455	6	infected	infect	VBN
cord-000372-wzwpyvll	455	7	cells	cell	NNS
cord-000372-wzwpyvll	455	8	,	,	,
cord-000372-wzwpyvll	455	9	these	these	DT
cord-000372-wzwpyvll	455	10	cardioviruses	cardioviruse	NNS
cord-000372-wzwpyvll	455	11	induce	induce	VBP
cord-000372-wzwpyvll	455	12	both	both	DT
cord-000372-wzwpyvll	455	13	protein	protein	NN
cord-000372-wzwpyvll	455	14	nuclear	nuclear	JJ
cord-000372-wzwpyvll	455	15	import	import	NN
cord-000372-wzwpyvll	455	16	inhibition	inhibition	NN
cord-000372-wzwpyvll	455	17	and	and	CC
cord-000372-wzwpyvll	455	18	late	late	JJ
cord-000372-wzwpyvll	455	19	membrane	membrane	NN
cord-000372-wzwpyvll	455	20	leakiness	leakiness	NN
cord-000372-wzwpyvll	456	1	but	but	CC
cord-000372-wzwpyvll	456	2	they	-PRON-	PRP
cord-000372-wzwpyvll	456	3	do	do	VBP
cord-000372-wzwpyvll	456	4	not	not	RB
cord-000372-wzwpyvll	456	5	induce	induce	VB
cord-000372-wzwpyvll	456	6	the	the	DT
cord-000372-wzwpyvll	456	7	cleavage	cleavage	NN
cord-000372-wzwpyvll	456	8	of	of	IN
cord-000372-wzwpyvll	456	9	Nups	Nups	NNP
cord-000372-wzwpyvll	456	10	[	[	-LRB-
cord-000372-wzwpyvll	456	11	160	160	CD
cord-000372-wzwpyvll	456	12	,	,	,
cord-000372-wzwpyvll	456	13	202	202	CD
cord-000372-wzwpyvll	456	14	,	,	,
cord-000372-wzwpyvll	456	15	203	203	CD
cord-000372-wzwpyvll	456	16	]	]	-RRB-
cord-000372-wzwpyvll	456	17	.	.	.
cord-000372-wzwpyvll	457	1	Cardioviruses	Cardioviruses	NNP
cord-000372-wzwpyvll	457	2	encode	encode	VBP
cord-000372-wzwpyvll	457	3	an	an	DT
cord-000372-wzwpyvll	457	4	additional	additional	JJ
cord-000372-wzwpyvll	457	5	protein	protein	NN
cord-000372-wzwpyvll	457	6	known	know	VBN
cord-000372-wzwpyvll	457	7	as	as	IN
cord-000372-wzwpyvll	457	8	L	L	NNP
cord-000372-wzwpyvll	457	9	protein	protein	NN
cord-000372-wzwpyvll	457	10	,	,	,
cord-000372-wzwpyvll	457	11	which	which	WDT
cord-000372-wzwpyvll	457	12	is	be	VBZ
cord-000372-wzwpyvll	457	13	highly	highly	RB
cord-000372-wzwpyvll	457	14	cytopathic	cytopathic	JJ
cord-000372-wzwpyvll	457	15	although	although	IN
cord-000372-wzwpyvll	457	16	it	-PRON-	PRP
cord-000372-wzwpyvll	457	17	lacks	lack	VBZ
cord-000372-wzwpyvll	457	18	protease	protease	NN
cord-000372-wzwpyvll	457	19	activity	activity	NN
cord-000372-wzwpyvll	457	20	(	(	-LRB-
cord-000372-wzwpyvll	457	21	in	in	IN
cord-000372-wzwpyvll	457	22	contrast	contrast	NN
cord-000372-wzwpyvll	457	23	to	to	IN
cord-000372-wzwpyvll	457	24	aphthovirus	aphthovirus	NNP
cord-000372-wzwpyvll	457	25	L	L	NNP
cord-000372-wzwpyvll	457	26	pro	pro	NNP
cord-000372-wzwpyvll	457	27	)	)	-RRB-
cord-000372-wzwpyvll	457	28	.	.	.
cord-000372-wzwpyvll	458	1	L	L	NNP
cord-000372-wzwpyvll	458	2	protein	protein	NN
cord-000372-wzwpyvll	458	3	contains	contain	VBZ
cord-000372-wzwpyvll	458	4	a	a	DT
cord-000372-wzwpyvll	458	5	Zinc	zinc	NN
cord-000372-wzwpyvll	458	6	finger	finger	NN
cord-000372-wzwpyvll	458	7	domain	domain	NN
cord-000372-wzwpyvll	458	8	,	,	,
cord-000372-wzwpyvll	458	9	and	and	CC
cord-000372-wzwpyvll	458	10	an	an	DT
cord-000372-wzwpyvll	458	11	acidic	acidic	JJ
cord-000372-wzwpyvll	458	12	region	region	NN
cord-000372-wzwpyvll	458	13	,	,	,
cord-000372-wzwpyvll	458	14	which	which	WDT
cord-000372-wzwpyvll	458	15	is	be	VBZ
cord-000372-wzwpyvll	458	16	proposed	propose	VBN
cord-000372-wzwpyvll	458	17	to	to	TO
cord-000372-wzwpyvll	458	18	be	be	VB
cord-000372-wzwpyvll	458	19	phosphorylated	phosphorylate	VBN
cord-000372-wzwpyvll	458	20	in	in	IN
cord-000372-wzwpyvll	458	21	infected	infected	JJ
cord-000372-wzwpyvll	458	22	cells	cell	NNS
cord-000372-wzwpyvll	458	23	[	[	-LRB-
cord-000372-wzwpyvll	458	24	204	204	CD
cord-000372-wzwpyvll	458	25	]	]	-RRB-
cord-000372-wzwpyvll	458	26	.	.	.
cord-000372-wzwpyvll	459	1	Individual	individual	JJ
cord-000372-wzwpyvll	459	2	expression	expression	NN
cord-000372-wzwpyvll	459	3	of	of	IN
cord-000372-wzwpyvll	459	4	this	this	DT
cord-000372-wzwpyvll	459	5	protein	protein	NN
cord-000372-wzwpyvll	459	6	in	in	IN
cord-000372-wzwpyvll	459	7	cultured	cultured	JJ
cord-000372-wzwpyvll	459	8	cells	cell	NNS
cord-000372-wzwpyvll	459	9	or	or	CC
cord-000372-wzwpyvll	459	10	in	in	IN
cord-000372-wzwpyvll	459	11	cell	cell	NN
cord-000372-wzwpyvll	459	12	-	-	HYPH
cord-000372-wzwpyvll	459	13	free	free	JJ
cord-000372-wzwpyvll	459	14	systems	system	NNS
cord-000372-wzwpyvll	459	15	induces	induce	VBZ
cord-000372-wzwpyvll	459	16	several	several	JJ
cord-000372-wzwpyvll	459	17	cellular	cellular	JJ
cord-000372-wzwpyvll	459	18	disorders	disorder	NNS
cord-000372-wzwpyvll	459	19	including	include	VBG
cord-000372-wzwpyvll	459	20	the	the	DT
cord-000372-wzwpyvll	459	21	inhibition	inhibition	NN
cord-000372-wzwpyvll	459	22	of	of	IN
cord-000372-wzwpyvll	459	23	protein	protein	NN
cord-000372-wzwpyvll	459	24	nuclear	nuclear	JJ
cord-000372-wzwpyvll	459	25	import	import	NN
cord-000372-wzwpyvll	459	26	that	that	WDT
cord-000372-wzwpyvll	459	27	resembles	resemble	VBZ
cord-000372-wzwpyvll	459	28	that	that	IN
cord-000372-wzwpyvll	459	29	observed	observe	VBD
cord-000372-wzwpyvll	459	30	in	in	IN
cord-000372-wzwpyvll	459	31	EMCV	EMCV	NNP
cord-000372-wzwpyvll	459	32	-	-	HYPH
cord-000372-wzwpyvll	459	33	infected	infect	VBN
cord-000372-wzwpyvll	459	34	cells	cell	NNS
cord-000372-wzwpyvll	459	35	[	[	-LRB-
cord-000372-wzwpyvll	459	36	160	160	CD
cord-000372-wzwpyvll	459	37	,	,	,
cord-000372-wzwpyvll	459	38	203	203	CD
cord-000372-wzwpyvll	459	39	]	]	-RRB-
cord-000372-wzwpyvll	459	40	.	.	.
cord-000372-wzwpyvll	460	1	Several	several	JJ
cord-000372-wzwpyvll	460	2	studies	study	NNS
cord-000372-wzwpyvll	460	3	reported	report	VBD
cord-000372-wzwpyvll	460	4	EMCV	EMCV	NNP
cord-000372-wzwpyvll	460	5	L	L	NNP
cord-000372-wzwpyvll	460	6	protein	protein	NN
cord-000372-wzwpyvll	460	7	mutations	mutation	NNS
cord-000372-wzwpyvll	460	8	that	that	WDT
cord-000372-wzwpyvll	460	9	resulted	result	VBD
cord-000372-wzwpyvll	460	10	in	in	IN
cord-000372-wzwpyvll	460	11	defective	defective	JJ
cord-000372-wzwpyvll	460	12	virus	virus	NN
cord-000372-wzwpyvll	460	13	growth	growth	NN
cord-000372-wzwpyvll	460	14	phenotypes	phenotype	NNS
cord-000372-wzwpyvll	460	15	in	in	IN
cord-000372-wzwpyvll	460	16	cell	cell	NN
cord-000372-wzwpyvll	460	17	culture	culture	NN
cord-000372-wzwpyvll	460	18	[	[	-LRB-
cord-000372-wzwpyvll	460	19	202	202	CD
cord-000372-wzwpyvll	460	20	,	,	,
cord-000372-wzwpyvll	460	21	204	204	CD
cord-000372-wzwpyvll	460	22	]	]	-RRB-
cord-000372-wzwpyvll	460	23	.	.	.
cord-000372-wzwpyvll	461	1	In	in	IN
cord-000372-wzwpyvll	461	2	particular	particular	JJ
cord-000372-wzwpyvll	461	3	,	,	,
cord-000372-wzwpyvll	461	4	mutations	mutation	NNS
cord-000372-wzwpyvll	461	5	in	in	IN
cord-000372-wzwpyvll	461	6	the	the	DT
cord-000372-wzwpyvll	461	7	zinc	zinc	NN
cord-000372-wzwpyvll	461	8	finger	finger	NN
cord-000372-wzwpyvll	461	9	domain	domain	NN
cord-000372-wzwpyvll	461	10	(	(	-LRB-
cord-000372-wzwpyvll	461	11	Cys19Ala	Cys19Ala	NNP
cord-000372-wzwpyvll	461	12	and	and	CC
cord-000372-wzwpyvll	461	13	Cys22Ala	Cys22Ala	NNP
cord-000372-wzwpyvll	461	14	)	)	-RRB-
cord-000372-wzwpyvll	461	15	or	or	CC
cord-000372-wzwpyvll	461	16	in	in	IN
cord-000372-wzwpyvll	461	17	the	the	DT
cord-000372-wzwpyvll	461	18	acidic	acidic	JJ
cord-000372-wzwpyvll	461	19	region	region	NN
cord-000372-wzwpyvll	461	20	(	(	-LRB-
cord-000372-wzwpyvll	461	21	Thr47Ala	thr47ala	NN
cord-000372-wzwpyvll	461	22	)	)	-RRB-
cord-000372-wzwpyvll	461	23	partially	partially	RB
cord-000372-wzwpyvll	461	24	avoid	avoid	VB
cord-000372-wzwpyvll	461	25	blockade	blockade	NN
cord-000372-wzwpyvll	461	26	of	of	IN
cord-000372-wzwpyvll	461	27	protein	protein	NN
cord-000372-wzwpyvll	461	28	trafficking	trafficking	NN
cord-000372-wzwpyvll	461	29	between	between	IN
cord-000372-wzwpyvll	461	30	the	the	DT
cord-000372-wzwpyvll	461	31	nucleus	nucleus	NN
cord-000372-wzwpyvll	461	32	and	and	CC
cord-000372-wzwpyvll	461	33	the	the	DT
cord-000372-wzwpyvll	461	34	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	461	35	[	[	-LRB-
cord-000372-wzwpyvll	461	36	202	202	CD
cord-000372-wzwpyvll	461	37	]	]	-RRB-
cord-000372-wzwpyvll	461	38	.	.	.
cord-000372-wzwpyvll	462	1	Taken	take	VBN
cord-000372-wzwpyvll	462	2	together	together	RB
cord-000372-wzwpyvll	462	3	,	,	,
cord-000372-wzwpyvll	462	4	these	these	DT
cord-000372-wzwpyvll	462	5	data	datum	NNS
cord-000372-wzwpyvll	462	6	support	support	VBP
cord-000372-wzwpyvll	462	7	the	the	DT
cord-000372-wzwpyvll	462	8	involvement	involvement	NN
cord-000372-wzwpyvll	462	9	of	of	IN
cord-000372-wzwpyvll	462	10	cardiovirus	cardiovirus	NNP
cord-000372-wzwpyvll	462	11	L	L	NNP
cord-000372-wzwpyvll	462	12	protein	protein	NN
cord-000372-wzwpyvll	462	13	in	in	IN
cord-000372-wzwpyvll	462	14	NPC	NPC	NNP
cord-000372-wzwpyvll	462	15	damaging	damage	VBG
cord-000372-wzwpyvll	462	16	and	and	CC
cord-000372-wzwpyvll	462	17	in	in	IN
cord-000372-wzwpyvll	462	18	the	the	DT
cord-000372-wzwpyvll	462	19	inhibition	inhibition	NN
cord-000372-wzwpyvll	462	20	of	of	IN
cord-000372-wzwpyvll	462	21	protein	protein	NN
cord-000372-wzwpyvll	462	22	nuclear	nuclear	JJ
cord-000372-wzwpyvll	462	23	import	import	NN
cord-000372-wzwpyvll	462	24	,	,	,
cord-000372-wzwpyvll	462	25	inducing	induce	VBG
cord-000372-wzwpyvll	462	26	Nups	Nups	NNP
cord-000372-wzwpyvll	462	27	phosphorylation	phosphorylation	NN
cord-000372-wzwpyvll	462	28	rather	rather	RB
cord-000372-wzwpyvll	462	29	than	than	IN
cord-000372-wzwpyvll	462	30	their	-PRON-	PRP$
cord-000372-wzwpyvll	462	31	cleavage	cleavage	NN
cord-000372-wzwpyvll	462	32	.	.	.
cord-000372-wzwpyvll	463	1	Indeed	indeed	RB
cord-000372-wzwpyvll	463	2	,	,	,
cord-000372-wzwpyvll	463	3	Nup62	Nup62	NNP
cord-000372-wzwpyvll	463	4	is	be	VBZ
cord-000372-wzwpyvll	463	5	quickly	quickly	RB
cord-000372-wzwpyvll	463	6	and	and	CC
cord-000372-wzwpyvll	463	7	strongly	strongly	RB
cord-000372-wzwpyvll	463	8	phosphorylated	phosphorylated	JJ
cord-000372-wzwpyvll	463	9	after	after	IN
cord-000372-wzwpyvll	463	10	EMCV	EMCV	NNP
cord-000372-wzwpyvll	463	11	infection	infection	NN
cord-000372-wzwpyvll	463	12	(	(	-LRB-
cord-000372-wzwpyvll	463	13	2	2	CD
cord-000372-wzwpyvll	463	14	hpi	hpi	NNP
cord-000372-wzwpyvll	463	15	)	)	-RRB-
cord-000372-wzwpyvll	463	16	,	,	,
cord-000372-wzwpyvll	463	17	and	and	CC
cord-000372-wzwpyvll	463	18	it	-PRON-	PRP
cord-000372-wzwpyvll	463	19	was	be	VBD
cord-000372-wzwpyvll	463	20	clearly	clearly	RB
cord-000372-wzwpyvll	463	21	detected	detect	VBN
cord-000372-wzwpyvll	463	22	by	by	IN
cord-000372-wzwpyvll	463	23	conventional	conventional	JJ
cord-000372-wzwpyvll	463	24	Western	western	JJ
cord-000372-wzwpyvll	463	25	blotting	blotting	NN
cord-000372-wzwpyvll	463	26	.	.	.
cord-000372-wzwpyvll	464	1	Nevertheless	nevertheless	RB
cord-000372-wzwpyvll	464	2	,	,	,
cord-000372-wzwpyvll	464	3	analysis	analysis	NN
cord-000372-wzwpyvll	464	4	with	with	IN
cord-000372-wzwpyvll	464	5	Pro	Pro	NNP
cord-000372-wzwpyvll	464	6	-	-	JJ
cord-000372-wzwpyvll	464	7	Q	q	JJ
cord-000372-wzwpyvll	464	8	diamond	diamond	NN
cord-000372-wzwpyvll	464	9	phosphoprotein	phosphoprotein	NN
cord-000372-wzwpyvll	464	10	stain	stain	NN
cord-000372-wzwpyvll	464	11	revealed	reveal	VBD
cord-000372-wzwpyvll	464	12	that	that	IN
cord-000372-wzwpyvll	464	13	Nup153	nup153	CD
cord-000372-wzwpyvll	464	14	and	and	CC
cord-000372-wzwpyvll	464	15	Nup214	nup214	CD
cord-000372-wzwpyvll	464	16	are	be	VBP
cord-000372-wzwpyvll	464	17	also	also	RB
cord-000372-wzwpyvll	464	18	phosphorylated	phosphorylate	VBN
cord-000372-wzwpyvll	464	19	to	to	IN
cord-000372-wzwpyvll	464	20	a	a	DT
cord-000372-wzwpyvll	464	21	certain	certain	JJ
cord-000372-wzwpyvll	464	22	extent	extent	NN
cord-000372-wzwpyvll	464	23	upon	upon	IN
cord-000372-wzwpyvll	464	24	EMCV	EMCV	NNP
cord-000372-wzwpyvll	464	25	infection	infection	NN
cord-000372-wzwpyvll	464	26	.	.	.
cord-000372-wzwpyvll	465	1	Notably	notably	RB
cord-000372-wzwpyvll	465	2	,	,	,
cord-000372-wzwpyvll	465	3	Nups	Nups	NNP
cord-000372-wzwpyvll	465	4	phosphorylation	phosphorylation	NN
cord-000372-wzwpyvll	465	5	was	be	VBD
cord-000372-wzwpyvll	465	6	avoided	avoid	VBN
cord-000372-wzwpyvll	465	7	when	when	WRB
cord-000372-wzwpyvll	465	8	Cys19Ala	Cys19Ala	NNP
cord-000372-wzwpyvll	465	9	mutation	mutation	NN
cord-000372-wzwpyvll	465	10	was	be	VBD
cord-000372-wzwpyvll	465	11	inserted	insert	VBN
cord-000372-wzwpyvll	465	12	in	in	IN
cord-000372-wzwpyvll	465	13	the	the	DT
cord-000372-wzwpyvll	465	14	L	L	NNP
cord-000372-wzwpyvll	465	15	protein	protein	NN
cord-000372-wzwpyvll	465	16	sequence	sequence	NN
cord-000372-wzwpyvll	465	17	,	,	,
cord-000372-wzwpyvll	465	18	suggesting	suggest	VBG
cord-000372-wzwpyvll	465	19	that	that	IN
cord-000372-wzwpyvll	465	20	the	the	DT
cord-000372-wzwpyvll	465	21	Zinc	Zinc	NNP
cord-000372-wzwpyvll	465	22	finger	finger	NN
cord-000372-wzwpyvll	465	23	domain	domain	NN
cord-000372-wzwpyvll	465	24	is	be	VBZ
cord-000372-wzwpyvll	465	25	essential	essential	JJ
cord-000372-wzwpyvll	465	26	for	for	IN
cord-000372-wzwpyvll	465	27	this	this	DT
cord-000372-wzwpyvll	465	28	posttranslational	posttranslational	JJ
cord-000372-wzwpyvll	465	29	modification	modification	NN
cord-000372-wzwpyvll	465	30	to	to	TO
cord-000372-wzwpyvll	465	31	occur	occur	VB
cord-000372-wzwpyvll	465	32	[	[	-LRB-
cord-000372-wzwpyvll	465	33	160	160	CD
cord-000372-wzwpyvll	465	34	]	]	-RRB-
cord-000372-wzwpyvll	465	35	.	.	.
cord-000372-wzwpyvll	466	1	However	however	RB
cord-000372-wzwpyvll	466	2	,	,	,
cord-000372-wzwpyvll	466	3	the	the	DT
cord-000372-wzwpyvll	466	4	exact	exact	JJ
cord-000372-wzwpyvll	466	5	role	role	NN
cord-000372-wzwpyvll	466	6	of	of	IN
cord-000372-wzwpyvll	466	7	Nups	Nups	NNP
cord-000372-wzwpyvll	466	8	phosphorylation	phosphorylation	NN
cord-000372-wzwpyvll	466	9	in	in	IN
cord-000372-wzwpyvll	466	10	nuclear	nuclear	JJ
cord-000372-wzwpyvll	466	11	-	-	HYPH
cord-000372-wzwpyvll	466	12	cytoplasmic	cytoplasmic	JJ
cord-000372-wzwpyvll	466	13	trafficking	trafficking	NN
cord-000372-wzwpyvll	466	14	is	be	VBZ
cord-000372-wzwpyvll	466	15	still	still	RB
cord-000372-wzwpyvll	466	16	unknown	unknown	JJ
cord-000372-wzwpyvll	466	17	.	.	.
cord-000372-wzwpyvll	467	1	The	the	DT
cord-000372-wzwpyvll	467	2	idea	idea	NN
cord-000372-wzwpyvll	467	3	that	that	IN
cord-000372-wzwpyvll	467	4	Nups	Nups	NNP
cord-000372-wzwpyvll	467	5	phosphorylation	phosphorylation	NN
cord-000372-wzwpyvll	467	6	could	could	MD
cord-000372-wzwpyvll	467	7	regulate	regulate	VB
cord-000372-wzwpyvll	467	8	protein	protein	NN
cord-000372-wzwpyvll	467	9	import	import	NN
cord-000372-wzwpyvll	467	10	and	and	CC
cord-000372-wzwpyvll	467	11	RNA	RNA	NNP
cord-000372-wzwpyvll	467	12	export	export	NN
cord-000372-wzwpyvll	467	13	as	as	IN
cord-000372-wzwpyvll	467	14	a	a	DT
cord-000372-wzwpyvll	467	15	switch	switch	NN
cord-000372-wzwpyvll	467	16	that	that	WDT
cord-000372-wzwpyvll	467	17	turns	turn	VBZ
cord-000372-wzwpyvll	467	18	the	the	DT
cord-000372-wzwpyvll	467	19	different	different	JJ
cord-000372-wzwpyvll	467	20	pathways	pathway	NNS
cord-000372-wzwpyvll	467	21	on	on	IN
cord-000372-wzwpyvll	467	22	/	/	SYM
cord-000372-wzwpyvll	467	23	off	off	RB
cord-000372-wzwpyvll	467	24	should	should	MD
cord-000372-wzwpyvll	467	25	be	be	VB
cord-000372-wzwpyvll	467	26	pursued	pursue	VBN
cord-000372-wzwpyvll	467	27	in	in	IN
cord-000372-wzwpyvll	467	28	more	more	JJR
cord-000372-wzwpyvll	467	29	detail	detail	NN
cord-000372-wzwpyvll	467	30	.	.	.
cord-000372-wzwpyvll	468	1	As	as	IN
cord-000372-wzwpyvll	468	2	mentioned	mention	VBN
cord-000372-wzwpyvll	468	3	above	above	RB
cord-000372-wzwpyvll	468	4	,	,	,
cord-000372-wzwpyvll	468	5	Ran	run	VBD
cord-000372-wzwpyvll	468	6	is	be	VBZ
cord-000372-wzwpyvll	468	7	essential	essential	JJ
cord-000372-wzwpyvll	468	8	for	for	IN
cord-000372-wzwpyvll	468	9	the	the	DT
cord-000372-wzwpyvll	468	10	regulation	regulation	NN
cord-000372-wzwpyvll	468	11	of	of	IN
cord-000372-wzwpyvll	468	12	most	most	JJS
cord-000372-wzwpyvll	468	13	of	of	IN
cord-000372-wzwpyvll	468	14	the	the	DT
cord-000372-wzwpyvll	468	15	nuclear	nuclear	JJ
cord-000372-wzwpyvll	468	16	export	export	NN
cord-000372-wzwpyvll	468	17	and	and	CC
cord-000372-wzwpyvll	468	18	import	import	NN
cord-000372-wzwpyvll	468	19	pathways	pathway	NNS
cord-000372-wzwpyvll	468	20	,	,	,
cord-000372-wzwpyvll	468	21	because	because	IN
cord-000372-wzwpyvll	468	22	it	-PRON-	PRP
cord-000372-wzwpyvll	468	23	acts	act	VBZ
cord-000372-wzwpyvll	468	24	as	as	IN
cord-000372-wzwpyvll	468	25	a	a	DT
cord-000372-wzwpyvll	468	26	cofactor	cofactor	NN
cord-000372-wzwpyvll	468	27	modulating	modulate	VBG
cord-000372-wzwpyvll	468	28	the	the	DT
cord-000372-wzwpyvll	468	29	affinity	affinity	NN
cord-000372-wzwpyvll	468	30	of	of	IN
cord-000372-wzwpyvll	468	31	importins	importin	NNS
cord-000372-wzwpyvll	468	32	and	and	CC
cord-000372-wzwpyvll	468	33	exportins	exportin	NNS
cord-000372-wzwpyvll	468	34	for	for	IN
cord-000372-wzwpyvll	468	35	the	the	DT
cord-000372-wzwpyvll	468	36	cargo	cargo	NN
cord-000372-wzwpyvll	468	37	.	.	.
cord-000372-wzwpyvll	469	1	The	the	DT
cord-000372-wzwpyvll	469	2	RanGTP	rangtp	NN
cord-000372-wzwpyvll	469	3	cycle	cycle	NN
cord-000372-wzwpyvll	469	4	is	be	VBZ
cord-000372-wzwpyvll	469	5	described	describe	VBN
cord-000372-wzwpyvll	469	6	in	in	IN
cord-000372-wzwpyvll	469	7	detail	detail	NN
cord-000372-wzwpyvll	469	8	in	in	IN
cord-000372-wzwpyvll	469	9	Section	section	NN
cord-000372-wzwpyvll	469	10	6.1	6.1	CD
cord-000372-wzwpyvll	469	11	.	.	.
cord-000372-wzwpyvll	470	1	It	-PRON-	PRP
cord-000372-wzwpyvll	470	2	has	have	VBZ
cord-000372-wzwpyvll	470	3	been	be	VBN
cord-000372-wzwpyvll	470	4	described	describe	VBN
cord-000372-wzwpyvll	470	5	that	that	IN
cord-000372-wzwpyvll	470	6	EMCV	EMCV	NNP
cord-000372-wzwpyvll	470	7	L	L	NNP
cord-000372-wzwpyvll	470	8	directly	directly	RB
cord-000372-wzwpyvll	470	9	interacts	interact	VBZ
cord-000372-wzwpyvll	470	10	with	with	IN
cord-000372-wzwpyvll	470	11	Ran	Ran	NNP
cord-000372-wzwpyvll	470	12	,	,	,
cord-000372-wzwpyvll	470	13	and	and	CC
cord-000372-wzwpyvll	470	14	this	this	DT
cord-000372-wzwpyvll	470	15	interaction	interaction	NN
cord-000372-wzwpyvll	470	16	is	be	VBZ
cord-000372-wzwpyvll	470	17	abrogated	abrogate	VBN
cord-000372-wzwpyvll	470	18	by	by	IN
cord-000372-wzwpyvll	470	19	the	the	DT
cord-000372-wzwpyvll	470	20	insertion	insertion	NN
cord-000372-wzwpyvll	470	21	of	of	IN
cord-000372-wzwpyvll	470	22	C19A	C19A	NNP
cord-000372-wzwpyvll	470	23	mutation	mutation	NN
cord-000372-wzwpyvll	470	24	in	in	IN
cord-000372-wzwpyvll	470	25	L	L	NNP
cord-000372-wzwpyvll	470	26	[	[	-LRB-
cord-000372-wzwpyvll	470	27	203	203	CD
cord-000372-wzwpyvll	470	28	]	]	-RRB-
cord-000372-wzwpyvll	470	29	.	.	.
cord-000372-wzwpyvll	471	1	However	however	RB
cord-000372-wzwpyvll	471	2	,	,	,
cord-000372-wzwpyvll	471	3	the	the	DT
cord-000372-wzwpyvll	471	4	potential	potential	JJ
cord-000372-wzwpyvll	471	5	role	role	NN
cord-000372-wzwpyvll	471	6	of	of	IN
cord-000372-wzwpyvll	471	7	L	L	NNP
cord-000372-wzwpyvll	471	8	/	/	,
cord-000372-wzwpyvll	471	9	Ran	ran	NN
cord-000372-wzwpyvll	471	10	interaction	interaction	NN
cord-000372-wzwpyvll	471	11	in	in	IN
cord-000372-wzwpyvll	471	12	the	the	DT
cord-000372-wzwpyvll	471	13	modulation	modulation	NN
cord-000372-wzwpyvll	471	14	of	of	IN
cord-000372-wzwpyvll	471	15	RanGTP	rangtp	NN
cord-000372-wzwpyvll	471	16	cycle	cycle	NN
cord-000372-wzwpyvll	471	17	and	and	CC
cord-000372-wzwpyvll	471	18	its	-PRON-	PRP$
cord-000372-wzwpyvll	471	19	impact	impact	NN
cord-000372-wzwpyvll	471	20	in	in	IN
cord-000372-wzwpyvll	471	21	nuclear	nuclear	JJ
cord-000372-wzwpyvll	471	22	import	import	NN
cord-000372-wzwpyvll	471	23	and	and	CC
cord-000372-wzwpyvll	471	24	export	export	NN
cord-000372-wzwpyvll	471	25	pathways	pathway	NNS
cord-000372-wzwpyvll	471	26	have	have	VBP
cord-000372-wzwpyvll	471	27	not	not	RB
cord-000372-wzwpyvll	471	28	yet	yet	RB
cord-000372-wzwpyvll	471	29	been	be	VBN
cord-000372-wzwpyvll	471	30	studied	study	VBN
cord-000372-wzwpyvll	471	31	.	.	.
cord-000372-wzwpyvll	472	1	Alteration	alteration	NN
cord-000372-wzwpyvll	472	2	of	of	IN
cord-000372-wzwpyvll	472	3	nuclear	nuclear	JJ
cord-000372-wzwpyvll	472	4	-	-	HYPH
cord-000372-wzwpyvll	472	5	cytoplasmic	cytoplasmic	JJ
cord-000372-wzwpyvll	472	6	trafficking	trafficking	NN
cord-000372-wzwpyvll	472	7	is	be	VBZ
cord-000372-wzwpyvll	472	8	not	not	RB
cord-000372-wzwpyvll	472	9	only	only	RB
cord-000372-wzwpyvll	472	10	restricted	restrict	VBN
cord-000372-wzwpyvll	472	11	to	to	IN
cord-000372-wzwpyvll	472	12	picornaviruses	picornavirus	NNS
cord-000372-wzwpyvll	472	13	but	but	CC
cord-000372-wzwpyvll	472	14	has	have	VBZ
cord-000372-wzwpyvll	472	15	also	also	RB
cord-000372-wzwpyvll	472	16	been	be	VBN
cord-000372-wzwpyvll	472	17	observed	observe	VBN
cord-000372-wzwpyvll	472	18	with	with	IN
cord-000372-wzwpyvll	472	19	negative	negative	JJ
cord-000372-wzwpyvll	472	20	strand	strand	NN
cord-000372-wzwpyvll	472	21	viruses	virus	NNS
cord-000372-wzwpyvll	472	22	such	such	JJ
cord-000372-wzwpyvll	472	23	as	as	IN
cord-000372-wzwpyvll	472	24	vesicular	vesicular	JJ
cord-000372-wzwpyvll	472	25	stomatitis	stomatitis	NN
cord-000372-wzwpyvll	472	26	virus	virus	NN
cord-000372-wzwpyvll	472	27	(	(	-LRB-
cord-000372-wzwpyvll	472	28	VSV	VSV	NNP
cord-000372-wzwpyvll	472	29	)	)	-RRB-
cord-000372-wzwpyvll	472	30	and	and	CC
cord-000372-wzwpyvll	472	31	influenza	influenza	NN
cord-000372-wzwpyvll	472	32	virus	virus	NN
cord-000372-wzwpyvll	472	33	.	.	.
cord-000372-wzwpyvll	473	1	Her	-PRON-	PRP
cord-000372-wzwpyvll	473	2	and	and	CC
cord-000372-wzwpyvll	473	3	collaborators	collaborator	NNS
cord-000372-wzwpyvll	473	4	reported	report	VBD
cord-000372-wzwpyvll	473	5	that	that	IN
cord-000372-wzwpyvll	473	6	RNA	RNA	NNP
cord-000372-wzwpyvll	473	7	export	export	NN
cord-000372-wzwpyvll	473	8	and	and	CC
cord-000372-wzwpyvll	473	9	protein	protein	NN
cord-000372-wzwpyvll	473	10	import	import	NN
cord-000372-wzwpyvll	473	11	are	be	VBP
cord-000372-wzwpyvll	473	12	strongly	strongly	RB
cord-000372-wzwpyvll	473	13	inhibited	inhibit	VBN
cord-000372-wzwpyvll	473	14	by	by	IN
cord-000372-wzwpyvll	473	15	VSV	VSV	NNP
cord-000372-wzwpyvll	473	16	matrix	matrix	NN
cord-000372-wzwpyvll	473	17	(	(	-LRB-
cord-000372-wzwpyvll	473	18	M	M	NNP
cord-000372-wzwpyvll	473	19	)	)	-RRB-
cord-000372-wzwpyvll	473	20	protein	protein	NN
cord-000372-wzwpyvll	473	21	,	,	,
cord-000372-wzwpyvll	473	22	by	by	IN
cord-000372-wzwpyvll	473	23	microinjection	microinjection	NN
cord-000372-wzwpyvll	473	24	of	of	IN
cord-000372-wzwpyvll	473	25	oocytes	oocyte	NNS
cord-000372-wzwpyvll	473	26	with	with	IN
cord-000372-wzwpyvll	473	27	radiolabeled	radiolabeled	JJ
cord-000372-wzwpyvll	473	28	RNAs	rna	NNS
cord-000372-wzwpyvll	473	29	and	and	CC
cord-000372-wzwpyvll	473	30	proteins	protein	NNS
cord-000372-wzwpyvll	473	31	.	.	.
cord-000372-wzwpyvll	474	1	Radiolabeled	radiolabele	VBN
cord-000372-wzwpyvll	474	2	tRNAs	trna	NNS
cord-000372-wzwpyvll	474	3	,	,	,
cord-000372-wzwpyvll	474	4	mRNAs	mrnas	UH
cord-000372-wzwpyvll	474	5	,	,	,
cord-000372-wzwpyvll	474	6	U	U	NNP
cord-000372-wzwpyvll	474	7	snRNAs	snRNAs	NNP
cord-000372-wzwpyvll	474	8	,	,	,
cord-000372-wzwpyvll	474	9	and	and	CC
cord-000372-wzwpyvll	474	10	rRNAs	rrna	NNS
cord-000372-wzwpyvll	474	11	were	be	VBD
cord-000372-wzwpyvll	474	12	injected	inject	VBN
cord-000372-wzwpyvll	474	13	directly	directly	RB
cord-000372-wzwpyvll	474	14	into	into	IN
cord-000372-wzwpyvll	474	15	the	the	DT
cord-000372-wzwpyvll	474	16	nucleus	nucleus	NN
cord-000372-wzwpyvll	474	17	of	of	IN
cord-000372-wzwpyvll	474	18	Xenopus	Xenopus	NNP
cord-000372-wzwpyvll	474	19	laevis	laevi	NNS
cord-000372-wzwpyvll	474	20	oocytes	oocyte	NNS
cord-000372-wzwpyvll	474	21	,	,	,
cord-000372-wzwpyvll	474	22	and	and	CC
cord-000372-wzwpyvll	474	23	the	the	DT
cord-000372-wzwpyvll	474	24	subcellular	subcellular	JJ
cord-000372-wzwpyvll	474	25	localization	localization	NN
cord-000372-wzwpyvll	474	26	of	of	IN
cord-000372-wzwpyvll	474	27	those	those	DT
cord-000372-wzwpyvll	474	28	RNAs	rna	NNS
cord-000372-wzwpyvll	474	29	was	be	VBD
cord-000372-wzwpyvll	474	30	monitored	monitor	VBN
cord-000372-wzwpyvll	474	31	by	by	IN
cord-000372-wzwpyvll	474	32	autoradiography	autoradiography	NNP
cord-000372-wzwpyvll	474	33	.	.	.
cord-000372-wzwpyvll	475	1	The	the	DT
cord-000372-wzwpyvll	475	2	conclusion	conclusion	NN
cord-000372-wzwpyvll	475	3	of	of	IN
cord-000372-wzwpyvll	475	4	this	this	DT
cord-000372-wzwpyvll	475	5	work	work	NN
cord-000372-wzwpyvll	475	6	is	be	VBZ
cord-000372-wzwpyvll	475	7	that	that	IN
cord-000372-wzwpyvll	475	8	mRNA	mRNA	NNP
cord-000372-wzwpyvll	475	9	,	,	,
cord-000372-wzwpyvll	475	10	U	U	NNP
cord-000372-wzwpyvll	475	11	snRNA	snrna	VBP
cord-000372-wzwpyvll	475	12	,	,	,
cord-000372-wzwpyvll	475	13	and	and	CC
cord-000372-wzwpyvll	475	14	rRNA	rrna	NN
cord-000372-wzwpyvll	475	15	but	but	CC
cord-000372-wzwpyvll	475	16	not	not	RB
cord-000372-wzwpyvll	475	17	tRNA	trna	NN
cord-000372-wzwpyvll	475	18	trafficking	trafficking	NN
cord-000372-wzwpyvll	475	19	is	be	VBZ
cord-000372-wzwpyvll	475	20	blocked	block	VBN
cord-000372-wzwpyvll	475	21	by	by	IN
cord-000372-wzwpyvll	475	22	VSV	VSV	NNP
cord-000372-wzwpyvll	475	23	M	M	NNP
cord-000372-wzwpyvll	475	24	protein	protein	NN
cord-000372-wzwpyvll	475	25	[	[	-LRB-
cord-000372-wzwpyvll	475	26	205	205	CD
cord-000372-wzwpyvll	475	27	]	]	-RRB-
cord-000372-wzwpyvll	475	28	,	,	,
cord-000372-wzwpyvll	475	29	in	in	IN
cord-000372-wzwpyvll	475	30	agreement	agreement	NN
cord-000372-wzwpyvll	475	31	with	with	IN
cord-000372-wzwpyvll	475	32	our	-PRON-	PRP$
cord-000372-wzwpyvll	475	33	findings	finding	NNS
cord-000372-wzwpyvll	475	34	on	on	IN
cord-000372-wzwpyvll	475	35	2A	2a	CD
cord-000372-wzwpyvll	475	36	proexpressing	proexpresse	VBG
cord-000372-wzwpyvll	475	37	HeLa	HeLa	NNP
cord-000372-wzwpyvll	475	38	cells	cell	NNS
cord-000372-wzwpyvll	475	39	[	[	-LRB-
cord-000372-wzwpyvll	475	40	17	17	CD
cord-000372-wzwpyvll	475	41	]	]	-RRB-
cord-000372-wzwpyvll	475	42	.	.	.
cord-000372-wzwpyvll	476	1	In	in	IN
cord-000372-wzwpyvll	476	2	addition	addition	NN
cord-000372-wzwpyvll	476	3	,	,	,
cord-000372-wzwpyvll	476	4	protein	protein	NN
cord-000372-wzwpyvll	476	5	nuclear	nuclear	JJ
cord-000372-wzwpyvll	476	6	import	import	NN
cord-000372-wzwpyvll	476	7	was	be	VBD
cord-000372-wzwpyvll	476	8	monitored	monitor	VBN
cord-000372-wzwpyvll	476	9	by	by	IN
cord-000372-wzwpyvll	476	10	microinjection	microinjection	NN
cord-000372-wzwpyvll	476	11	of	of	IN
cord-000372-wzwpyvll	476	12	radiolabeled	radiolabeled	JJ
cord-000372-wzwpyvll	476	13	proteins	protein	NNS
cord-000372-wzwpyvll	476	14	containing	contain	VBG
cord-000372-wzwpyvll	476	15	NLS	NLS	NNP
cord-000372-wzwpyvll	476	16	in	in	IN
cord-000372-wzwpyvll	476	17	the	the	DT
cord-000372-wzwpyvll	476	18	oocytes	oocyte	NNS
cord-000372-wzwpyvll	476	19	cytoplasm	cytoplasm	VBP
cord-000372-wzwpyvll	476	20	.	.	.
cord-000372-wzwpyvll	477	1	This	this	DT
cord-000372-wzwpyvll	477	2	assay	assay	NN
cord-000372-wzwpyvll	477	3	revealed	reveal	VBD
cord-000372-wzwpyvll	477	4	that	that	IN
cord-000372-wzwpyvll	477	5	VSV	VSV	NNP
cord-000372-wzwpyvll	477	6	M	M	NNP
cord-000372-wzwpyvll	477	7	protein	protein	NN
cord-000372-wzwpyvll	477	8	abrogates	abrogate	VBZ
cord-000372-wzwpyvll	477	9	protein	protein	NN
cord-000372-wzwpyvll	477	10	nuclear	nuclear	JJ
cord-000372-wzwpyvll	477	11	import	import	NN
cord-000372-wzwpyvll	477	12	to	to	IN
cord-000372-wzwpyvll	477	13	the	the	DT
cord-000372-wzwpyvll	477	14	same	same	JJ
cord-000372-wzwpyvll	477	15	extent	extent	NN
cord-000372-wzwpyvll	477	16	as	as	IN
cord-000372-wzwpyvll	477	17	treatment	treatment	NN
cord-000372-wzwpyvll	477	18	with	with	IN
cord-000372-wzwpyvll	477	19	specific	specific	JJ
cord-000372-wzwpyvll	477	20	inhibitors	inhibitor	NNS
cord-000372-wzwpyvll	477	21	of	of	IN
cord-000372-wzwpyvll	477	22	this	this	DT
cord-000372-wzwpyvll	477	23	pathway	pathway	NN
cord-000372-wzwpyvll	477	24	such	such	JJ
cord-000372-wzwpyvll	477	25	as	as	IN
cord-000372-wzwpyvll	477	26	WGA	WGA	NNP
cord-000372-wzwpyvll	477	27	[	[	-LRB-
cord-000372-wzwpyvll	477	28	205	205	CD
cord-000372-wzwpyvll	477	29	]	]	-RRB-
cord-000372-wzwpyvll	477	30	.	.	.
cord-000372-wzwpyvll	478	1	These	these	DT
cord-000372-wzwpyvll	478	2	interesting	interesting	JJ
cord-000372-wzwpyvll	478	3	findings	finding	NNS
cord-000372-wzwpyvll	478	4	support	support	VBP
cord-000372-wzwpyvll	478	5	the	the	DT
cord-000372-wzwpyvll	478	6	idea	idea	NN
cord-000372-wzwpyvll	478	7	that	that	IN
cord-000372-wzwpyvll	478	8	PV	PV	NNP
cord-000372-wzwpyvll	478	9	2A	2a	CD
cord-000372-wzwpyvll	478	10	pro	pro	JJ
cord-000372-wzwpyvll	478	11	and	and	CC
cord-000372-wzwpyvll	478	12	VSV	VSV	NNP
cord-000372-wzwpyvll	478	13	M	M	NNP
cord-000372-wzwpyvll	478	14	protein	protein	NN
cord-000372-wzwpyvll	478	15	could	could	MD
cord-000372-wzwpyvll	478	16	target	target	VB
cord-000372-wzwpyvll	478	17	similar	similar	JJ
cord-000372-wzwpyvll	478	18	host	host	NN
cord-000372-wzwpyvll	478	19	proteins	protein	NNS
cord-000372-wzwpyvll	478	20	to	to	TO
cord-000372-wzwpyvll	478	21	impair	impair	VB
cord-000372-wzwpyvll	478	22	macromolecule	macromolecule	NN
cord-000372-wzwpyvll	478	23	trafficking	trafficking	NN
cord-000372-wzwpyvll	478	24	between	between	IN
cord-000372-wzwpyvll	478	25	nucleus	nucleus	NN
cord-000372-wzwpyvll	478	26	and	and	CC
cord-000372-wzwpyvll	478	27	cytoplasm	cytoplasm	JJ
cord-000372-wzwpyvll	478	28	.	.	.
cord-000372-wzwpyvll	479	1	In	in	IN
cord-000372-wzwpyvll	479	2	agreement	agreement	NN
cord-000372-wzwpyvll	479	3	with	with	IN
cord-000372-wzwpyvll	479	4	this	this	DT
cord-000372-wzwpyvll	479	5	possibility	possibility	NN
cord-000372-wzwpyvll	479	6	,	,	,
cord-000372-wzwpyvll	479	7	it	-PRON-	PRP
cord-000372-wzwpyvll	479	8	was	be	VBD
cord-000372-wzwpyvll	479	9	found	find	VBN
cord-000372-wzwpyvll	479	10	that	that	IN
cord-000372-wzwpyvll	479	11	the	the	DT
cord-000372-wzwpyvll	479	12	VSV	VSV	NNP
cord-000372-wzwpyvll	479	13	M	M	NNP
cord-000372-wzwpyvll	479	14	protein	protein	NN
cord-000372-wzwpyvll	479	15	interacts	interact	VBZ
cord-000372-wzwpyvll	479	16	with	with	IN
cord-000372-wzwpyvll	479	17	Nup98	Nup98	NNP
cord-000372-wzwpyvll	479	18	[	[	-LRB-
cord-000372-wzwpyvll	479	19	161	161	CD
cord-000372-wzwpyvll	479	20	]	]	-RRB-
cord-000372-wzwpyvll	479	21	,	,	,
cord-000372-wzwpyvll	479	22	which	which	WDT
cord-000372-wzwpyvll	479	23	is	be	VBZ
cord-000372-wzwpyvll	479	24	one	one	CD
cord-000372-wzwpyvll	479	25	of	of	IN
cord-000372-wzwpyvll	479	26	the	the	DT
cord-000372-wzwpyvll	479	27	primary	primary	JJ
cord-000372-wzwpyvll	479	28	targets	target	NNS
cord-000372-wzwpyvll	479	29	of	of	IN
cord-000372-wzwpyvll	479	30	PV	PV	NNP
cord-000372-wzwpyvll	479	31	2A	2a	CD
cord-000372-wzwpyvll	479	32	pro	pro	JJ
cord-000372-wzwpyvll	479	33	[	[	-LRB-
cord-000372-wzwpyvll	479	34	16	16	CD
cord-000372-wzwpyvll	479	35	]	]	-RRB-
cord-000372-wzwpyvll	479	36	.	.	.
cord-000372-wzwpyvll	480	1	The	the	DT
cord-000372-wzwpyvll	480	2	N	n	CD
cord-000372-wzwpyvll	480	3	-	-	HYPH
cord-000372-wzwpyvll	480	4	terminal	terminal	NN
cord-000372-wzwpyvll	480	5	domain	domain	NN
cord-000372-wzwpyvll	480	6	of	of	IN
cord-000372-wzwpyvll	480	7	VSV	VSV	NNP
cord-000372-wzwpyvll	480	8	M	M	NNP
cord-000372-wzwpyvll	480	9	is	be	VBZ
cord-000372-wzwpyvll	480	10	sufficient	sufficient	JJ
cord-000372-wzwpyvll	480	11	to	to	TO
cord-000372-wzwpyvll	480	12	block	block	VB
cord-000372-wzwpyvll	480	13	RNA	RNA	NNP
cord-000372-wzwpyvll	480	14	nuclear	nuclear	JJ
cord-000372-wzwpyvll	480	15	export	export	NN
cord-000372-wzwpyvll	480	16	and	and	CC
cord-000372-wzwpyvll	480	17	aa	aa	NNP
cord-000372-wzwpyvll	480	18	52	52	CD
cord-000372-wzwpyvll	480	19	-	-	SYM
cord-000372-wzwpyvll	480	20	54	54	CD
cord-000372-wzwpyvll	480	21	may	may	MD
cord-000372-wzwpyvll	480	22	play	play	VB
cord-000372-wzwpyvll	480	23	an	an	DT
cord-000372-wzwpyvll	480	24	essential	essential	JJ
cord-000372-wzwpyvll	480	25	role	role	NN
cord-000372-wzwpyvll	480	26	in	in	IN
cord-000372-wzwpyvll	480	27	this	this	DT
cord-000372-wzwpyvll	480	28	blockade	blockade	NN
cord-000372-wzwpyvll	480	29	,	,	,
cord-000372-wzwpyvll	480	30	because	because	IN
cord-000372-wzwpyvll	480	31	their	-PRON-	PRP$
cord-000372-wzwpyvll	480	32	mutations	mutation	NNS
cord-000372-wzwpyvll	480	33	to	to	IN
cord-000372-wzwpyvll	480	34	Ala	Ala	NNP
cord-000372-wzwpyvll	480	35	completely	completely	RB
cord-000372-wzwpyvll	480	36	abrogate	abrogate	VB
cord-000372-wzwpyvll	480	37	this	this	DT
cord-000372-wzwpyvll	480	38	inhibitory	inhibitory	JJ
cord-000372-wzwpyvll	480	39	effect	effect	NN
cord-000372-wzwpyvll	480	40	.	.	.
cord-000372-wzwpyvll	481	1	Indeed	indeed	RB
cord-000372-wzwpyvll	481	2	,	,	,
cord-000372-wzwpyvll	481	3	the	the	DT
cord-000372-wzwpyvll	481	4	N	n	CD
cord-000372-wzwpyvll	481	5	-	-	HYPH
cord-000372-wzwpyvll	481	6	terminal	terminal	NN
cord-000372-wzwpyvll	481	7	domain	domain	NN
cord-000372-wzwpyvll	481	8	of	of	IN
cord-000372-wzwpyvll	481	9	M	M	NNP
cord-000372-wzwpyvll	481	10	protein	protein	NN
cord-000372-wzwpyvll	481	11	is	be	VBZ
cord-000372-wzwpyvll	481	12	involved	involve	VBN
cord-000372-wzwpyvll	481	13	in	in	IN
cord-000372-wzwpyvll	481	14	the	the	DT
cord-000372-wzwpyvll	481	15	interaction	interaction	NN
cord-000372-wzwpyvll	481	16	with	with	IN
cord-000372-wzwpyvll	481	17	Nup98	Nup98	NNP
cord-000372-wzwpyvll	481	18	and	and	CC
cord-000372-wzwpyvll	481	19	,	,	,
cord-000372-wzwpyvll	481	20	in	in	IN
cord-000372-wzwpyvll	481	21	particular	particular	JJ
cord-000372-wzwpyvll	481	22	,	,	,
cord-000372-wzwpyvll	481	23	aa	aa	NNP
cord-000372-wzwpyvll	481	24	52	52	CD
cord-000372-wzwpyvll	481	25	-	-	SYM
cord-000372-wzwpyvll	481	26	54	54	CD
cord-000372-wzwpyvll	481	27	,	,	,
cord-000372-wzwpyvll	481	28	because	because	IN
cord-000372-wzwpyvll	481	29	their	-PRON-	PRP$
cord-000372-wzwpyvll	481	30	mutation	mutation	NN
cord-000372-wzwpyvll	481	31	to	to	IN
cord-000372-wzwpyvll	481	32	Ala	Ala	NNP
cord-000372-wzwpyvll	481	33	blocks	block	VBZ
cord-000372-wzwpyvll	481	34	the	the	DT
cord-000372-wzwpyvll	481	35	binding	binding	NN
cord-000372-wzwpyvll	481	36	of	of	IN
cord-000372-wzwpyvll	481	37	VSV	VSV	NNP
cord-000372-wzwpyvll	481	38	M	M	NNP
cord-000372-wzwpyvll	481	39	to	to	IN
cord-000372-wzwpyvll	481	40	Nup98	Nup98	NNP
cord-000372-wzwpyvll	481	41	[	[	-LRB-
cord-000372-wzwpyvll	481	42	161	161	CD
cord-000372-wzwpyvll	481	43	]	]	-RRB-
cord-000372-wzwpyvll	481	44	.	.	.
cord-000372-wzwpyvll	482	1	In	in	IN
cord-000372-wzwpyvll	482	2	addition	addition	NN
cord-000372-wzwpyvll	482	3	,	,	,
cord-000372-wzwpyvll	482	4	binding	binding	NN
cord-000372-wzwpyvll	482	5	of	of	IN
cord-000372-wzwpyvll	482	6	M	M	NNP
cord-000372-wzwpyvll	482	7	to	to	IN
cord-000372-wzwpyvll	482	8	Nup98	Nup98	NNP
cord-000372-wzwpyvll	482	9	requires	require	VBZ
cord-000372-wzwpyvll	482	10	active	active	JJ
cord-000372-wzwpyvll	482	11	mRNA	mRNA	NNP
cord-000372-wzwpyvll	482	12	export	export	NN
cord-000372-wzwpyvll	482	13	pathways	pathway	NNS
cord-000372-wzwpyvll	482	14	since	since	IN
cord-000372-wzwpyvll	482	15	,	,	,
cord-000372-wzwpyvll	482	16	treatment	treatment	NN
cord-000372-wzwpyvll	482	17	with	with	IN
cord-000372-wzwpyvll	482	18	inhibitors	inhibitor	NNS
cord-000372-wzwpyvll	482	19	such	such	JJ
cord-000372-wzwpyvll	482	20	as	as	IN
cord-000372-wzwpyvll	482	21	WGA	WGA	NNP
cord-000372-wzwpyvll	482	22	hampers	hamper	VBZ
cord-000372-wzwpyvll	482	23	this	this	DT
cord-000372-wzwpyvll	482	24	interaction	interaction	NN
cord-000372-wzwpyvll	482	25	.	.	.
cord-000372-wzwpyvll	483	1	VSV	VSV	NNP
cord-000372-wzwpyvll	483	2	M	M	NNP
cord-000372-wzwpyvll	483	3	is	be	VBZ
cord-000372-wzwpyvll	483	4	also	also	RB
cord-000372-wzwpyvll	483	5	able	able	JJ
cord-000372-wzwpyvll	483	6	to	to	TO
cord-000372-wzwpyvll	483	7	induce	induce	VB
cord-000372-wzwpyvll	483	8	the	the	DT
cord-000372-wzwpyvll	483	9	accumulation	accumulation	NN
cord-000372-wzwpyvll	483	10	of	of	IN
cord-000372-wzwpyvll	483	11	endogenous	endogenous	JJ
cord-000372-wzwpyvll	483	12	polyadenylated	polyadenylate	VBN
cord-000372-wzwpyvll	483	13	mRNAs	mRNAs	-RRB-
cord-000372-wzwpyvll	483	14	in	in	IN
cord-000372-wzwpyvll	483	15	the	the	DT
cord-000372-wzwpyvll	483	16	nucleus	nucleus	NN
cord-000372-wzwpyvll	483	17	of	of	IN
cord-000372-wzwpyvll	483	18	HeLa	HeLa	NNP
cord-000372-wzwpyvll	483	19	cells	cell	NNS
cord-000372-wzwpyvll	483	20	,	,	,
cord-000372-wzwpyvll	483	21	and	and	CC
cord-000372-wzwpyvll	483	22	this	this	DT
cord-000372-wzwpyvll	483	23	effect	effect	NN
cord-000372-wzwpyvll	483	24	is	be	VBZ
cord-000372-wzwpyvll	483	25	prevented	prevent	VBN
cord-000372-wzwpyvll	483	26	again	again	RB
cord-000372-wzwpyvll	483	27	by	by	IN
cord-000372-wzwpyvll	483	28	mutations	mutation	NNS
cord-000372-wzwpyvll	483	29	in	in	IN
cord-000372-wzwpyvll	483	30	aa	aa	NNP
cord-000372-wzwpyvll	483	31	52	52	CD
cord-000372-wzwpyvll	483	32	-	-	SYM
cord-000372-wzwpyvll	483	33	54	54	CD
cord-000372-wzwpyvll	483	34	of	of	IN
cord-000372-wzwpyvll	483	35	M	M	NNP
cord-000372-wzwpyvll	483	36	[	[	-LRB-
cord-000372-wzwpyvll	483	37	161	161	CD
cord-000372-wzwpyvll	483	38	]	]	-RRB-
cord-000372-wzwpyvll	483	39	.	.	.
cord-000372-wzwpyvll	484	1	Furthermore	furthermore	RB
cord-000372-wzwpyvll	484	2	,	,	,
cord-000372-wzwpyvll	484	3	VSV	VSV	NNP
cord-000372-wzwpyvll	484	4	M	M	NNP
cord-000372-wzwpyvll	484	5	interacts	interact	VBZ
cord-000372-wzwpyvll	484	6	with	with	IN
cord-000372-wzwpyvll	484	7	Rae1	Rae1	NNP
cord-000372-wzwpyvll	484	8	,	,	,
cord-000372-wzwpyvll	484	9	which	which	WDT
cord-000372-wzwpyvll	484	10	plays	play	VBZ
cord-000372-wzwpyvll	484	11	an	an	DT
cord-000372-wzwpyvll	484	12	essential	essential	JJ
cord-000372-wzwpyvll	484	13	role	role	NN
cord-000372-wzwpyvll	484	14	in	in	IN
cord-000372-wzwpyvll	484	15	mRNA	mRNA	NNP
cord-000372-wzwpyvll	484	16	nuclear	nuclear	JJ
cord-000372-wzwpyvll	484	17	export	export	NN
cord-000372-wzwpyvll	484	18	by	by	IN
cord-000372-wzwpyvll	484	19	its	-PRON-	PRP$
cord-000372-wzwpyvll	484	20	interaction	interaction	NN
cord-000372-wzwpyvll	484	21	with	with	IN
cord-000372-wzwpyvll	484	22	Nup98	Nup98	NNP
cord-000372-wzwpyvll	484	23	and	and	CC
cord-000372-wzwpyvll	484	24	mRNPs	mRNPs	NNP
cord-000372-wzwpyvll	484	25	.	.	.
cord-000372-wzwpyvll	485	1	Overexpression	overexpression	NN
cord-000372-wzwpyvll	485	2	of	of	IN
cord-000372-wzwpyvll	485	3	either	either	DT
cord-000372-wzwpyvll	485	4	Nup98	Nup98	NNP
cord-000372-wzwpyvll	485	5	or	or	CC
cord-000372-wzwpyvll	485	6	Rae-1	Rae-1	NNP
cord-000372-wzwpyvll	485	7	prevents	prevent	VBZ
cord-000372-wzwpyvll	485	8	the	the	DT
cord-000372-wzwpyvll	485	9	nuclear	nuclear	JJ
cord-000372-wzwpyvll	485	10	accumulation	accumulation	NN
cord-000372-wzwpyvll	485	11	of	of	IN
cord-000372-wzwpyvll	485	12	polyadenylated	polyadenylated	JJ
cord-000372-wzwpyvll	485	13	mRNAs	mRNAs	NNPS
cord-000372-wzwpyvll	485	14	,	,	,
cord-000372-wzwpyvll	485	15	suggesting	suggest	VBG
cord-000372-wzwpyvll	485	16	that	that	IN
cord-000372-wzwpyvll	485	17	both	both	DT
cord-000372-wzwpyvll	485	18	factors	factor	NNS
cord-000372-wzwpyvll	485	19	may	may	MD
cord-000372-wzwpyvll	485	20	play	play	VB
cord-000372-wzwpyvll	485	21	a	a	DT
cord-000372-wzwpyvll	485	22	role	role	NN
cord-000372-wzwpyvll	485	23	in	in	IN
cord-000372-wzwpyvll	485	24	the	the	DT
cord-000372-wzwpyvll	485	25	blockade	blockade	NN
cord-000372-wzwpyvll	485	26	of	of	IN
cord-000372-wzwpyvll	485	27	mRNA	mRNA	NNP
cord-000372-wzwpyvll	485	28	nuclear	nuclear	JJ
cord-000372-wzwpyvll	485	29	export	export	NN
cord-000372-wzwpyvll	485	30	by	by	IN
cord-000372-wzwpyvll	485	31	VSV	VSV	NNP
cord-000372-wzwpyvll	485	32	M	M	NNP
cord-000372-wzwpyvll	485	33	protein	protein	NN
cord-000372-wzwpyvll	485	34	[	[	-LRB-
cord-000372-wzwpyvll	485	35	206	206	CD
cord-000372-wzwpyvll	485	36	]	]	-RRB-
cord-000372-wzwpyvll	485	37	.	.	.
cord-000372-wzwpyvll	486	1	Interestingly	interestingly	RB
cord-000372-wzwpyvll	486	2	,	,	,
cord-000372-wzwpyvll	486	3	IFN	IFN	NNP
cord-000372-wzwpyvll	486	4	-	-	HYPH
cord-000372-wzwpyvll	486	5	γ	γ	NNP
cord-000372-wzwpyvll	486	6	specifically	specifically	RB
cord-000372-wzwpyvll	486	7	increases	increase	VBZ
cord-000372-wzwpyvll	486	8	the	the	DT
cord-000372-wzwpyvll	486	9	level	level	NN
cord-000372-wzwpyvll	486	10	of	of	IN
cord-000372-wzwpyvll	486	11	both	both	DT
cord-000372-wzwpyvll	486	12	Nup98	Nup98	NNP
cord-000372-wzwpyvll	486	13	and	and	CC
cord-000372-wzwpyvll	486	14	Rae-1	Rae-1	NNP
cord-000372-wzwpyvll	486	15	and	and	CC
cord-000372-wzwpyvll	486	16	indicates	indicate	VBZ
cord-000372-wzwpyvll	486	17	a	a	DT
cord-000372-wzwpyvll	486	18	potential	potential	JJ
cord-000372-wzwpyvll	486	19	antiviral	antiviral	JJ
cord-000372-wzwpyvll	486	20	effect	effect	NN
cord-000372-wzwpyvll	486	21	of	of	IN
cord-000372-wzwpyvll	486	22	these	these	DT
cord-000372-wzwpyvll	486	23	proteins	protein	NNS
cord-000372-wzwpyvll	486	24	.	.	.
cord-000372-wzwpyvll	487	1	Indeed	indeed	RB
cord-000372-wzwpyvll	487	2	,	,	,
cord-000372-wzwpyvll	487	3	overexpression	overexpression	NN
cord-000372-wzwpyvll	487	4	of	of	IN
cord-000372-wzwpyvll	487	5	both	both	DT
cord-000372-wzwpyvll	487	6	proteins	protein	NNS
cord-000372-wzwpyvll	487	7	by	by	IN
cord-000372-wzwpyvll	487	8	IFN	IFN	NNP
cord-000372-wzwpyvll	487	9	-	-	HYPH
cord-000372-wzwpyvll	487	10	γ	γ	NN
cord-000372-wzwpyvll	487	11	treatment	treatment	NN
cord-000372-wzwpyvll	487	12	counteracts	counteract	VBZ
cord-000372-wzwpyvll	487	13	the	the	DT
cord-000372-wzwpyvll	487	14	inhibitory	inhibitory	JJ
cord-000372-wzwpyvll	487	15	effects	effect	NNS
cord-000372-wzwpyvll	487	16	of	of	IN
cord-000372-wzwpyvll	487	17	VSV	VSV	NNP
cord-000372-wzwpyvll	487	18	M	M	NNP
cord-000372-wzwpyvll	487	19	protein	protein	NN
cord-000372-wzwpyvll	487	20	on	on	IN
cord-000372-wzwpyvll	487	21	mRNA	mRNA	NNP
cord-000372-wzwpyvll	487	22	nuclear	nuclear	JJ
cord-000372-wzwpyvll	487	23	export	export	NN
cord-000372-wzwpyvll	487	24	,	,	,
cord-000372-wzwpyvll	487	25	highlighting	highlight	VBG
cord-000372-wzwpyvll	487	26	the	the	DT
cord-000372-wzwpyvll	487	27	possibility	possibility	NN
cord-000372-wzwpyvll	487	28	of	of	IN
cord-000372-wzwpyvll	487	29	a	a	DT
cord-000372-wzwpyvll	487	30	crosstalk	crosstalk	NN
cord-000372-wzwpyvll	487	31	between	between	IN
cord-000372-wzwpyvll	487	32	M	M	NNP
cord-000372-wzwpyvll	487	33	and	and	CC
cord-000372-wzwpyvll	487	34	IFN	IFN	NNP
cord-000372-wzwpyvll	487	35	-	-	HYPH
cord-000372-wzwpyvll	487	36	γ	γ	NNP
cord-000372-wzwpyvll	487	37	that	that	WDT
cord-000372-wzwpyvll	487	38	might	may	MD
cord-000372-wzwpyvll	487	39	control	control	VB
cord-000372-wzwpyvll	487	40	the	the	DT
cord-000372-wzwpyvll	487	41	fate	fate	NN
cord-000372-wzwpyvll	487	42	of	of	IN
cord-000372-wzwpyvll	487	43	the	the	DT
cord-000372-wzwpyvll	487	44	viral	viral	JJ
cord-000372-wzwpyvll	487	45	replication	replication	NN
cord-000372-wzwpyvll	487	46	in	in	IN
cord-000372-wzwpyvll	487	47	infected	infected	JJ
cord-000372-wzwpyvll	487	48	animals	animal	NNS
cord-000372-wzwpyvll	487	49	[	[	-LRB-
cord-000372-wzwpyvll	487	50	201	201	CD
cord-000372-wzwpyvll	487	51	,	,	,
cord-000372-wzwpyvll	487	52	206	206	CD
cord-000372-wzwpyvll	487	53	]	]	-RRB-
cord-000372-wzwpyvll	487	54	.	.	.
cord-000372-wzwpyvll	488	1	Influenza	influenza	NN
cord-000372-wzwpyvll	488	2	virus	virus	NN
cord-000372-wzwpyvll	488	3	replication	replication	NN
cord-000372-wzwpyvll	488	4	also	also	RB
cord-000372-wzwpyvll	488	5	impacts	impact	VBZ
cord-000372-wzwpyvll	488	6	on	on	IN
cord-000372-wzwpyvll	488	7	nuclearcytoplasmic	nuclearcytoplasmic	JJ
cord-000372-wzwpyvll	488	8	trafficking	trafficking	NN
cord-000372-wzwpyvll	488	9	and	and	CC
cord-000372-wzwpyvll	488	10	leads	lead	VBZ
cord-000372-wzwpyvll	488	11	to	to	IN
cord-000372-wzwpyvll	488	12	the	the	DT
cord-000372-wzwpyvll	488	13	nuclear	nuclear	JJ
cord-000372-wzwpyvll	488	14	accumulation	accumulation	NN
cord-000372-wzwpyvll	488	15	of	of	IN
cord-000372-wzwpyvll	488	16	host	host	NN
cord-000372-wzwpyvll	489	1	mRNAs	mrnas	LS
cord-000372-wzwpyvll	489	2	[	[	-LRB-
cord-000372-wzwpyvll	489	3	162	162	CD
cord-000372-wzwpyvll	489	4	,	,	,
cord-000372-wzwpyvll	489	5	207	207	CD
cord-000372-wzwpyvll	489	6	]	]	-RRB-
cord-000372-wzwpyvll	489	7	.	.	.
cord-000372-wzwpyvll	490	1	Influenza	influenza	NN
cord-000372-wzwpyvll	490	2	virus	virus	NN
cord-000372-wzwpyvll	490	3	NS1	ns1	NN
cord-000372-wzwpyvll	490	4	protein	protein	NN
cord-000372-wzwpyvll	490	5	is	be	VBZ
cord-000372-wzwpyvll	490	6	a	a	DT
cord-000372-wzwpyvll	490	7	major	major	JJ
cord-000372-wzwpyvll	490	8	virulence	virulence	NN
cord-000372-wzwpyvll	490	9	factor	factor	NN
cord-000372-wzwpyvll	490	10	that	that	WDT
cord-000372-wzwpyvll	490	11	is	be	VBZ
cord-000372-wzwpyvll	490	12	essential	essential	JJ
cord-000372-wzwpyvll	490	13	for	for	IN
cord-000372-wzwpyvll	490	14	pathogenesis	pathogenesis	NN
cord-000372-wzwpyvll	490	15	,	,	,
cord-000372-wzwpyvll	490	16	because	because	IN
cord-000372-wzwpyvll	490	17	it	-PRON-	PRP
cord-000372-wzwpyvll	490	18	impairs	impair	VBZ
cord-000372-wzwpyvll	490	19	innate	innate	JJ
cord-000372-wzwpyvll	490	20	and	and	CC
cord-000372-wzwpyvll	490	21	adaptive	adaptive	JJ
cord-000372-wzwpyvll	490	22	immunity	immunity	NN
cord-000372-wzwpyvll	490	23	by	by	IN
cord-000372-wzwpyvll	490	24	inhibiting	inhibit	VBG
cord-000372-wzwpyvll	490	25	host	host	NN
cord-000372-wzwpyvll	490	26	signal	signal	NN
cord-000372-wzwpyvll	490	27	transduction	transduction	NN
cord-000372-wzwpyvll	490	28	and	and	CC
cord-000372-wzwpyvll	490	29	gene	gene	NN
cord-000372-wzwpyvll	490	30	expression	expression	NN
cord-000372-wzwpyvll	490	31	[	[	-LRB-
cord-000372-wzwpyvll	490	32	208	208	CD
cord-000372-wzwpyvll	490	33	,	,	,
cord-000372-wzwpyvll	490	34	209	209	CD
cord-000372-wzwpyvll	490	35	]	]	-RRB-
cord-000372-wzwpyvll	490	36	.	.	.
cord-000372-wzwpyvll	491	1	NS1	ns1	UH
cord-000372-wzwpyvll	491	2	forms	form	VBZ
cord-000372-wzwpyvll	491	3	a	a	DT
cord-000372-wzwpyvll	491	4	complex	complex	NN
cord-000372-wzwpyvll	491	5	with	with	IN
cord-000372-wzwpyvll	491	6	NXF1	NXF1	NNP
cord-000372-wzwpyvll	491	7	/	/	SYM
cord-000372-wzwpyvll	491	8	TAP	TAP	NNP
cord-000372-wzwpyvll	491	9	,	,	,
cord-000372-wzwpyvll	491	10	p15	p15	NN
cord-000372-wzwpyvll	491	11	/	/	SYM
cord-000372-wzwpyvll	491	12	NXT	NXT	NNP
cord-000372-wzwpyvll	491	13	[	[	-LRB-
cord-000372-wzwpyvll	491	14	162	162	CD
cord-000372-wzwpyvll	491	15	]	]	-RRB-
cord-000372-wzwpyvll	491	16	,	,	,
cord-000372-wzwpyvll	491	17	Rae1	Rae1	NNP
cord-000372-wzwpyvll	491	18	,	,	,
cord-000372-wzwpyvll	491	19	and	and	CC
cord-000372-wzwpyvll	491	20	E1B	E1B	NNS
cord-000372-wzwpyvll	491	21	-	-	HYPH
cord-000372-wzwpyvll	491	22	AP5	AP5	NNP
cord-000372-wzwpyvll	491	23	,	,	,
cord-000372-wzwpyvll	491	24	which	which	WDT
cord-000372-wzwpyvll	491	25	are	be	VBP
cord-000372-wzwpyvll	491	26	components	component	NNS
cord-000372-wzwpyvll	491	27	of	of	IN
cord-000372-wzwpyvll	491	28	the	the	DT
cord-000372-wzwpyvll	491	29	mRNA	mRNA	NNP
cord-000372-wzwpyvll	491	30	nuclear	nuclear	JJ
cord-000372-wzwpyvll	491	31	export	export	NN
cord-000372-wzwpyvll	491	32	machinery	machinery	NN
cord-000372-wzwpyvll	491	33	(	(	-LRB-
cord-000372-wzwpyvll	491	34	see	see	VB
cord-000372-wzwpyvll	491	35	above	above	RB
cord-000372-wzwpyvll	491	36	)	)	-RRB-
cord-000372-wzwpyvll	491	37	.	.	.
cord-000372-wzwpyvll	492	1	Individual	individual	JJ
cord-000372-wzwpyvll	492	2	expression	expression	NN
cord-000372-wzwpyvll	492	3	of	of	IN
cord-000372-wzwpyvll	492	4	NS1	ns1	NN
cord-000372-wzwpyvll	492	5	in	in	IN
cord-000372-wzwpyvll	492	6	293	293	CD
cord-000372-wzwpyvll	492	7	T	T	NNP
cord-000372-wzwpyvll	492	8	cells	cell	NNS
cord-000372-wzwpyvll	492	9	induces	induce	VBZ
cord-000372-wzwpyvll	492	10	the	the	DT
cord-000372-wzwpyvll	492	11	accumulation	accumulation	NN
cord-000372-wzwpyvll	492	12	of	of	IN
cord-000372-wzwpyvll	492	13	polyadenylated	polyadenylated	NNP
cord-000372-wzwpyvll	492	14	mRNAs	mRNAs	NNPS
cord-000372-wzwpyvll	492	15	in	in	IN
cord-000372-wzwpyvll	492	16	the	the	DT
cord-000372-wzwpyvll	492	17	nucleus	nucleus	NN
cord-000372-wzwpyvll	492	18	,	,	,
cord-000372-wzwpyvll	492	19	suggesting	suggest	VBG
cord-000372-wzwpyvll	492	20	that	that	IN
cord-000372-wzwpyvll	492	21	the	the	DT
cord-000372-wzwpyvll	492	22	interaction	interaction	NN
cord-000372-wzwpyvll	492	23	of	of	IN
cord-000372-wzwpyvll	492	24	NS1	ns1	NN
cord-000372-wzwpyvll	492	25	with	with	IN
cord-000372-wzwpyvll	492	26	these	these	DT
cord-000372-wzwpyvll	492	27	export	export	NN
cord-000372-wzwpyvll	492	28	factors	factor	NNS
cord-000372-wzwpyvll	492	29	yields	yield	VBZ
cord-000372-wzwpyvll	492	30	an	an	DT
cord-000372-wzwpyvll	492	31	inactive	inactive	JJ
cord-000372-wzwpyvll	492	32	complex	complex	NN
cord-000372-wzwpyvll	492	33	for	for	IN
cord-000372-wzwpyvll	492	34	mRNA	mRNA	NNP
cord-000372-wzwpyvll	492	35	export	export	NN
cord-000372-wzwpyvll	492	36	.	.	.
cord-000372-wzwpyvll	493	1	Influenza	influenza	NN
cord-000372-wzwpyvll	493	2	virus	virus	NN
cord-000372-wzwpyvll	493	3	also	also	RB
cord-000372-wzwpyvll	493	4	induces	induce	VBZ
cord-000372-wzwpyvll	493	5	a	a	DT
cord-000372-wzwpyvll	493	6	strong	strong	JJ
cord-000372-wzwpyvll	493	7	reduction	reduction	NN
cord-000372-wzwpyvll	493	8	of	of	IN
cord-000372-wzwpyvll	493	9	Nup98	Nup98	NNP
cord-000372-wzwpyvll	493	10	steady	steady	JJ
cord-000372-wzwpyvll	493	11	-	-	HYPH
cord-000372-wzwpyvll	493	12	state	state	NN
cord-000372-wzwpyvll	493	13	levels	level	NNS
cord-000372-wzwpyvll	493	14	although	although	IN
cord-000372-wzwpyvll	493	15	the	the	DT
cord-000372-wzwpyvll	493	16	viral	viral	JJ
cord-000372-wzwpyvll	493	17	mechanisms	mechanism	NNS
cord-000372-wzwpyvll	493	18	involved	involve	VBN
cord-000372-wzwpyvll	493	19	in	in	IN
cord-000372-wzwpyvll	493	20	this	this	DT
cord-000372-wzwpyvll	493	21	process	process	NN
cord-000372-wzwpyvll	493	22	are	be	VBP
cord-000372-wzwpyvll	493	23	still	still	RB
cord-000372-wzwpyvll	493	24	unknown	unknown	JJ
cord-000372-wzwpyvll	493	25	[	[	-LRB-
cord-000372-wzwpyvll	493	26	162	162	CD
cord-000372-wzwpyvll	493	27	]	]	-RRB-
cord-000372-wzwpyvll	493	28	.	.	.
cord-000372-wzwpyvll	494	1	Expression	expression	NN
cord-000372-wzwpyvll	494	2	of	of	IN
cord-000372-wzwpyvll	494	3	reporter	reporter	NN
cord-000372-wzwpyvll	494	4	luciferase	luciferase	NN
cord-000372-wzwpyvll	494	5	mRNA	mRNA	NNP
cord-000372-wzwpyvll	494	6	synthesized	synthesize	VBN
cord-000372-wzwpyvll	494	7	from	from	IN
cord-000372-wzwpyvll	494	8	a	a	DT
cord-000372-wzwpyvll	494	9	nuclear	nuclear	JJ
cord-000372-wzwpyvll	494	10	plasmid	plasmid	NN
cord-000372-wzwpyvll	494	11	is	be	VBZ
cord-000372-wzwpyvll	494	12	inhibited	inhibit	VBN
cord-000372-wzwpyvll	494	13	by	by	IN
cord-000372-wzwpyvll	494	14	NS1	NS1	NNS
cord-000372-wzwpyvll	494	15	.	.	.
cord-000372-wzwpyvll	495	1	However	however	RB
cord-000372-wzwpyvll	495	2	,	,	,
cord-000372-wzwpyvll	495	3	this	this	DT
cord-000372-wzwpyvll	495	4	inhibition	inhibition	NN
cord-000372-wzwpyvll	495	5	is	be	VBZ
cord-000372-wzwpyvll	495	6	overcome	overcome	VBN
cord-000372-wzwpyvll	495	7	by	by	IN
cord-000372-wzwpyvll	495	8	overexpression	overexpression	NN
cord-000372-wzwpyvll	495	9	of	of	IN
cord-000372-wzwpyvll	495	10	NXF1	NXF1	NNP
cord-000372-wzwpyvll	495	11	,	,	,
cord-000372-wzwpyvll	495	12	p15	p15	NN
cord-000372-wzwpyvll	495	13	,	,	,
cord-000372-wzwpyvll	495	14	Rae-1	Rae-1	NNP
cord-000372-wzwpyvll	495	15	or	or	CC
cord-000372-wzwpyvll	495	16	Nup98	Nup98	NNP
cord-000372-wzwpyvll	495	17	,	,	,
cord-000372-wzwpyvll	495	18	evidencing	evidence	VBG
cord-000372-wzwpyvll	495	19	the	the	DT
cord-000372-wzwpyvll	495	20	role	role	NN
cord-000372-wzwpyvll	495	21	of	of	IN
cord-000372-wzwpyvll	495	22	NS1	ns1	NN
cord-000372-wzwpyvll	495	23	interaction	interaction	NN
cord-000372-wzwpyvll	495	24	with	with	IN
cord-000372-wzwpyvll	495	25	these	these	DT
cord-000372-wzwpyvll	495	26	factors	factor	NNS
cord-000372-wzwpyvll	495	27	in	in	IN
cord-000372-wzwpyvll	495	28	the	the	DT
cord-000372-wzwpyvll	495	29	impairment	impairment	NN
cord-000372-wzwpyvll	495	30	of	of	IN
cord-000372-wzwpyvll	495	31	mRNA	mRNA	NNP
cord-000372-wzwpyvll	495	32	nuclear	nuclear	JJ
cord-000372-wzwpyvll	495	33	export	export	NN
cord-000372-wzwpyvll	495	34	[	[	-LRB-
cord-000372-wzwpyvll	495	35	162	162	CD
cord-000372-wzwpyvll	495	36	]	]	-RRB-
cord-000372-wzwpyvll	495	37	.	.	.
cord-000372-wzwpyvll	496	1	Furthermore	furthermore	RB
cord-000372-wzwpyvll	496	2	,	,	,
cord-000372-wzwpyvll	496	3	mouse	mouse	NN
cord-000372-wzwpyvll	496	4	cells	cell	NNS
cord-000372-wzwpyvll	496	5	expressing	express	VBG
cord-000372-wzwpyvll	496	6	low	low	JJ
cord-000372-wzwpyvll	496	7	levels	level	NNS
cord-000372-wzwpyvll	496	8	of	of	IN
cord-000372-wzwpyvll	496	9	Nup98	Nup98	NNP
cord-000372-wzwpyvll	496	10	or	or	CC
cord-000372-wzwpyvll	496	11	/	/	SYM
cord-000372-wzwpyvll	496	12	and	and	CC
cord-000372-wzwpyvll	496	13	Rae-1	Rae-1	NNP
cord-000372-wzwpyvll	496	14	show	show	VBP
cord-000372-wzwpyvll	496	15	greater	great	JJR
cord-000372-wzwpyvll	496	16	susceptibility	susceptibility	NN
cord-000372-wzwpyvll	496	17	to	to	IN
cord-000372-wzwpyvll	496	18	influenza	influenza	NN
cord-000372-wzwpyvll	496	19	infection	infection	NN
cord-000372-wzwpyvll	496	20	,	,	,
cord-000372-wzwpyvll	496	21	resulting	result	VBG
cord-000372-wzwpyvll	496	22	in	in	IN
cord-000372-wzwpyvll	496	23	a	a	DT
cord-000372-wzwpyvll	496	24	significant	significant	JJ
cord-000372-wzwpyvll	496	25	increase	increase	NN
cord-000372-wzwpyvll	496	26	in	in	IN
cord-000372-wzwpyvll	496	27	cell	cell	NN
cord-000372-wzwpyvll	496	28	death	death	NN
cord-000372-wzwpyvll	496	29	and	and	CC
cord-000372-wzwpyvll	496	30	virus	virus	NN
cord-000372-wzwpyvll	496	31	production	production	NN
cord-000372-wzwpyvll	496	32	.	.	.
cord-000372-wzwpyvll	497	1	In	in	IN
cord-000372-wzwpyvll	497	2	addition	addition	NN
cord-000372-wzwpyvll	497	3	,	,	,
cord-000372-wzwpyvll	497	4	mRNAs	mrnas	IN
cord-000372-wzwpyvll	497	5	encoding	encode	VBG
cord-000372-wzwpyvll	497	6	antiviral	antiviral	JJ
cord-000372-wzwpyvll	497	7	factors	factor	NNS
cord-000372-wzwpyvll	497	8	or	or	CC
cord-000372-wzwpyvll	497	9	immunomodulators	immunomodulator	NNS
cord-000372-wzwpyvll	497	10	such	such	JJ
cord-000372-wzwpyvll	497	11	as	as	IN
cord-000372-wzwpyvll	497	12	IRF-1	IRF-1	NNP
cord-000372-wzwpyvll	497	13	,	,	,
cord-000372-wzwpyvll	497	14	MHC	MHC	NNP
cord-000372-wzwpyvll	497	15	I	I	NNP
cord-000372-wzwpyvll	497	16	and	and	CC
cord-000372-wzwpyvll	497	17	ICAM1	ICAM1	NNP
cord-000372-wzwpyvll	497	18	accumulated	accumulate	VBD
cord-000372-wzwpyvll	497	19	more	more	JJR
cord-000372-wzwpyvll	497	20	in	in	IN
cord-000372-wzwpyvll	497	21	the	the	DT
cord-000372-wzwpyvll	497	22	nucleus	nucleus	NN
cord-000372-wzwpyvll	497	23	of	of	IN
cord-000372-wzwpyvll	497	24	those	those	DT
cord-000372-wzwpyvll	497	25	cells	cell	NNS
cord-000372-wzwpyvll	497	26	than	than	IN
cord-000372-wzwpyvll	497	27	in	in	IN
cord-000372-wzwpyvll	497	28	cells	cell	NNS
cord-000372-wzwpyvll	497	29	expressing	express	VBG
cord-000372-wzwpyvll	497	30	normal	normal	JJ
cord-000372-wzwpyvll	497	31	levels	level	NNS
cord-000372-wzwpyvll	497	32	of	of	IN
cord-000372-wzwpyvll	497	33	Nup98	Nup98	NNP
cord-000372-wzwpyvll	497	34	or	or	CC
cord-000372-wzwpyvll	497	35	Rae-1	Rae-1	NNP
cord-000372-wzwpyvll	497	36	[	[	-LRB-
cord-000372-wzwpyvll	497	37	162	162	CD
cord-000372-wzwpyvll	497	38	]	]	-RRB-
cord-000372-wzwpyvll	497	39	.	.	.
cord-000372-wzwpyvll	498	1	All	all	PDT
cord-000372-wzwpyvll	498	2	these	these	DT
cord-000372-wzwpyvll	498	3	data	datum	NNS
cord-000372-wzwpyvll	498	4	support	support	VBP
cord-000372-wzwpyvll	498	5	the	the	DT
cord-000372-wzwpyvll	498	6	physiological	physiological	JJ
cord-000372-wzwpyvll	498	7	role	role	NN
cord-000372-wzwpyvll	498	8	of	of	IN
cord-000372-wzwpyvll	498	9	NS1	ns1	NN
cord-000372-wzwpyvll	498	10	interaction	interaction	NN
cord-000372-wzwpyvll	498	11	with	with	IN
cord-000372-wzwpyvll	498	12	RNA	RNA	NNP
cord-000372-wzwpyvll	498	13	export	export	NN
cord-000372-wzwpyvll	498	14	factors	factor	NNS
cord-000372-wzwpyvll	498	15	as	as	RB
cord-000372-wzwpyvll	498	16	well	well	RB
cord-000372-wzwpyvll	498	17	as	as	IN
cord-000372-wzwpyvll	498	18	the	the	DT
cord-000372-wzwpyvll	498	19	reduction	reduction	NN
cord-000372-wzwpyvll	498	20	of	of	IN
cord-000372-wzwpyvll	498	21	Nup98	Nup98	NNP
cord-000372-wzwpyvll	498	22	levels	level	NNS
cord-000372-wzwpyvll	498	23	in	in	IN
cord-000372-wzwpyvll	498	24	influenza	influenza	NN
cord-000372-wzwpyvll	498	25	pathogenicity	pathogenicity	NN
cord-000372-wzwpyvll	498	26	.	.	.
cord-000372-wzwpyvll	499	1	Interestingly	interestingly	RB
cord-000372-wzwpyvll	499	2	,	,	,
cord-000372-wzwpyvll	499	3	VSV	VSV	NNP
cord-000372-wzwpyvll	499	4	M	M	NNP
cord-000372-wzwpyvll	499	5	,	,	,
cord-000372-wzwpyvll	499	6	influenza	influenza	NN
cord-000372-wzwpyvll	499	7	NS1	ns1	NN
cord-000372-wzwpyvll	499	8	and	and	CC
cord-000372-wzwpyvll	499	9	PV	PV	NNP
cord-000372-wzwpyvll	499	10	2A	2a	CD
cord-000372-wzwpyvll	499	11	pro	pro	JJ
cord-000372-wzwpyvll	499	12	expression	expression	NN
cord-000372-wzwpyvll	499	13	gives	give	VBZ
cord-000372-wzwpyvll	499	14	rise	rise	NN
cord-000372-wzwpyvll	499	15	to	to	IN
cord-000372-wzwpyvll	499	16	similar	similar	JJ
cord-000372-wzwpyvll	499	17	effects	effect	NNS
cord-000372-wzwpyvll	499	18	on	on	IN
cord-000372-wzwpyvll	499	19	mRNA	mrna	NN
cord-000372-wzwpyvll	499	20	trafficking	trafficking	NN
cord-000372-wzwpyvll	499	21	.	.	.
cord-000372-wzwpyvll	500	1	All	all	PDT
cord-000372-wzwpyvll	500	2	these	these	DT
cord-000372-wzwpyvll	500	3	viral	viral	JJ
cord-000372-wzwpyvll	500	4	proteins	protein	NNS
cord-000372-wzwpyvll	500	5	target	target	VBP
cord-000372-wzwpyvll	500	6	Nup98	Nup98	NNP
cord-000372-wzwpyvll	500	7	and	and	CC
cord-000372-wzwpyvll	500	8	other	other	JJ
cord-000372-wzwpyvll	500	9	components	component	NNS
cord-000372-wzwpyvll	500	10	of	of	IN
cord-000372-wzwpyvll	500	11	the	the	DT
cord-000372-wzwpyvll	500	12	cellular	cellular	JJ
cord-000372-wzwpyvll	500	13	machinery	machinery	NN
cord-000372-wzwpyvll	500	14	involved	involve	VBN
cord-000372-wzwpyvll	500	15	in	in	IN
cord-000372-wzwpyvll	500	16	nuclear	nuclear	JJ
cord-000372-wzwpyvll	500	17	-	-	HYPH
cord-000372-wzwpyvll	500	18	cytoplasmic	cytoplasmic	JJ
cord-000372-wzwpyvll	500	19	trafficking	trafficking	NN
cord-000372-wzwpyvll	500	20	.	.	.
cord-000372-wzwpyvll	501	1	Survival	survival	NN
cord-000372-wzwpyvll	501	2	of	of	IN
cord-000372-wzwpyvll	501	3	motor	motor	NN
cord-000372-wzwpyvll	501	4	neurons	neuron	NNS
cord-000372-wzwpyvll	501	5	(	(	-LRB-
cord-000372-wzwpyvll	501	6	SMN	SMN	NNP
cord-000372-wzwpyvll	501	7	)	)	-RRB-
cord-000372-wzwpyvll	501	8	complex	complex	NN
cord-000372-wzwpyvll	501	9	is	be	VBZ
cord-000372-wzwpyvll	501	10	composed	compose	VBN
cord-000372-wzwpyvll	501	11	by	by	IN
cord-000372-wzwpyvll	501	12	SMN	SMN	NNP
cord-000372-wzwpyvll	501	13	and	and	CC
cord-000372-wzwpyvll	501	14	a	a	DT
cord-000372-wzwpyvll	501	15	class	class	NN
cord-000372-wzwpyvll	501	16	of	of	IN
cord-000372-wzwpyvll	501	17	proteins	protein	NNS
cord-000372-wzwpyvll	501	18	called	call	VBN
cord-000372-wzwpyvll	501	19	Gemins	Gemins	NNP
cord-000372-wzwpyvll	501	20	,	,	,
cord-000372-wzwpyvll	501	21	which	which	WDT
cord-000372-wzwpyvll	501	22	localize	localize	VBP
cord-000372-wzwpyvll	501	23	in	in	IN
cord-000372-wzwpyvll	501	24	both	both	DT
cord-000372-wzwpyvll	501	25	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	501	26	and	and	CC
cord-000372-wzwpyvll	501	27	nucleoplasm	nucleoplasm	NN
cord-000372-wzwpyvll	501	28	[	[	-LRB-
cord-000372-wzwpyvll	501	29	210	210	CD
cord-000372-wzwpyvll	501	30	,	,	,
cord-000372-wzwpyvll	501	31	211	211	CD
cord-000372-wzwpyvll	501	32	]	]	-RRB-
cord-000372-wzwpyvll	501	33	.	.	.
cord-000372-wzwpyvll	502	1	Gemin7	Gemin7	NNP
cord-000372-wzwpyvll	503	1	and	and	CC
cord-000372-wzwpyvll	503	2	Gemin8	Gemin8	NNP
cord-000372-wzwpyvll	503	3	constitute	constitute	VBP
cord-000372-wzwpyvll	503	4	the	the	DT
cord-000372-wzwpyvll	503	5	core	core	NN
cord-000372-wzwpyvll	503	6	of	of	IN
cord-000372-wzwpyvll	503	7	the	the	DT
cord-000372-wzwpyvll	503	8	complex	complex	NN
cord-000372-wzwpyvll	503	9	where	where	WRB
cord-000372-wzwpyvll	503	10	the	the	DT
cord-000372-wzwpyvll	503	11	other	other	JJ
cord-000372-wzwpyvll	503	12	Gemins	Gemins	NNP
cord-000372-wzwpyvll	503	13	associate	associate	NN
cord-000372-wzwpyvll	503	14	by	by	IN
cord-000372-wzwpyvll	503	15	means	mean	NNS
cord-000372-wzwpyvll	503	16	of	of	IN
cord-000372-wzwpyvll	503	17	numerous	numerous	JJ
cord-000372-wzwpyvll	503	18	proteinprotein	proteinprotein	NNP
cord-000372-wzwpyvll	503	19	interactions	interaction	NNS
cord-000372-wzwpyvll	503	20	from	from	IN
cord-000372-wzwpyvll	503	21	the	the	DT
cord-000372-wzwpyvll	503	22	periphery	periphery	NN
cord-000372-wzwpyvll	503	23	.	.	.
cord-000372-wzwpyvll	504	1	The	the	DT
cord-000372-wzwpyvll	504	2	SMN	SMN	NNP
cord-000372-wzwpyvll	504	3	complex	complex	NN
cord-000372-wzwpyvll	504	4	is	be	VBZ
cord-000372-wzwpyvll	504	5	involved	involve	VBN
cord-000372-wzwpyvll	504	6	in	in	IN
cord-000372-wzwpyvll	504	7	the	the	DT
cord-000372-wzwpyvll	504	8	biogenesis	biogenesis	NN
cord-000372-wzwpyvll	504	9	of	of	IN
cord-000372-wzwpyvll	504	10	uridine	uridine	NN
cord-000372-wzwpyvll	504	11	-	-	HYPH
cord-000372-wzwpyvll	504	12	rich	rich	JJ
cord-000372-wzwpyvll	504	13	small	small	JJ
cord-000372-wzwpyvll	504	14	nuclear	nuclear	JJ
cord-000372-wzwpyvll	504	15	ribonucleoprotein	ribonucleoprotein	NN
cord-000372-wzwpyvll	504	16	(	(	-LRB-
cord-000372-wzwpyvll	504	17	U	U	NNP
cord-000372-wzwpyvll	504	18	snRNP	snrnp	NN
cord-000372-wzwpyvll	504	19	)	)	-RRB-
cord-000372-wzwpyvll	504	20	in	in	IN
cord-000372-wzwpyvll	504	21	the	the	DT
cord-000372-wzwpyvll	504	22	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	505	1	and	and	CC
cord-000372-wzwpyvll	505	2	then	then	RB
cord-000372-wzwpyvll	505	3	the	the	DT
cord-000372-wzwpyvll	505	4	U	U	NNP
cord-000372-wzwpyvll	505	5	snRNP	snrnp	NN
cord-000372-wzwpyvll	505	6	carries	carry	VBZ
cord-000372-wzwpyvll	505	7	out	out	RP
cord-000372-wzwpyvll	505	8	the	the	DT
cord-000372-wzwpyvll	505	9	splicing	splicing	NN
cord-000372-wzwpyvll	505	10	of	of	IN
cord-000372-wzwpyvll	505	11	pre	pre	NN
cord-000372-wzwpyvll	505	12	-	-	NNS
cord-000372-wzwpyvll	505	13	mRNAs	mRNAs	NNPS
cord-000372-wzwpyvll	505	14	in	in	IN
cord-000372-wzwpyvll	505	15	the	the	DT
cord-000372-wzwpyvll	505	16	nucleus	nucleus	NN
cord-000372-wzwpyvll	505	17	[	[	-LRB-
cord-000372-wzwpyvll	505	18	212	212	CD
cord-000372-wzwpyvll	505	19	]	]	-RRB-
cord-000372-wzwpyvll	505	20	[	[	-LRB-
cord-000372-wzwpyvll	505	21	213	213	CD
cord-000372-wzwpyvll	505	22	]	]	-RRB-
cord-000372-wzwpyvll	505	23	[	[	-LRB-
cord-000372-wzwpyvll	505	24	214	214	CD
cord-000372-wzwpyvll	505	25	]	]	-RRB-
cord-000372-wzwpyvll	505	26	.	.	.
cord-000372-wzwpyvll	506	1	The	the	DT
cord-000372-wzwpyvll	506	2	snRNPs	snRNPs	NNPS
cord-000372-wzwpyvll	506	3	are	be	VBP
cord-000372-wzwpyvll	506	4	composed	compose	VBN
cord-000372-wzwpyvll	506	5	of	of	IN
cord-000372-wzwpyvll	506	6	the	the	DT
cord-000372-wzwpyvll	506	7	major	major	JJ
cord-000372-wzwpyvll	506	8	U	U	NNP
cord-000372-wzwpyvll	506	9	snRNAs	snRNAs	NNP
cord-000372-wzwpyvll	506	10	U1	U1	NNP
cord-000372-wzwpyvll	506	11	,	,	,
cord-000372-wzwpyvll	506	12	U2	U2	NNP
cord-000372-wzwpyvll	506	13	,	,	,
cord-000372-wzwpyvll	506	14	U4	u4	NN
cord-000372-wzwpyvll	506	15	,	,	,
cord-000372-wzwpyvll	506	16	U5	U5	NNP
cord-000372-wzwpyvll	506	17	,	,	,
cord-000372-wzwpyvll	506	18	and	and	CC
cord-000372-wzwpyvll	506	19	U6	U6	NNP
cord-000372-wzwpyvll	506	20	as	as	RB
cord-000372-wzwpyvll	506	21	well	well	RB
cord-000372-wzwpyvll	506	22	as	as	IN
cord-000372-wzwpyvll	506	23	a	a	DT
cord-000372-wzwpyvll	506	24	group	group	NN
cord-000372-wzwpyvll	506	25	of	of	IN
cord-000372-wzwpyvll	506	26	seven	seven	CD
cord-000372-wzwpyvll	506	27	proteins	protein	NNS
cord-000372-wzwpyvll	506	28	known	know	VBN
cord-000372-wzwpyvll	506	29	as	as	IN
cord-000372-wzwpyvll	506	30	Sm	Sm	NNP
cord-000372-wzwpyvll	506	31	ribonucleoproteins	ribonucleoprotein	NNS
cord-000372-wzwpyvll	506	32	that	that	WDT
cord-000372-wzwpyvll	506	33	collectively	collectively	RB
cord-000372-wzwpyvll	506	34	make	make	VB
cord-000372-wzwpyvll	506	35	up	up	RP
cord-000372-wzwpyvll	506	36	the	the	DT
cord-000372-wzwpyvll	506	37	extremely	extremely	RB
cord-000372-wzwpyvll	506	38	stable	stable	JJ
cord-000372-wzwpyvll	506	39	Sm	sm	NN
cord-000372-wzwpyvll	506	40	core	core	NN
cord-000372-wzwpyvll	506	41	of	of	IN
cord-000372-wzwpyvll	506	42	the	the	DT
cord-000372-wzwpyvll	506	43	snRNP	snrnp	NN
cord-000372-wzwpyvll	506	44	.	.	.
cord-000372-wzwpyvll	507	1	Gemins	Gemins	NNP
cord-000372-wzwpyvll	507	2	(	(	-LRB-
cord-000372-wzwpyvll	507	3	except	except	IN
cord-000372-wzwpyvll	507	4	Gemin-2	Gemin-2	NNP
cord-000372-wzwpyvll	507	5	)	)	-RRB-
cord-000372-wzwpyvll	507	6	associate	associate	NN
cord-000372-wzwpyvll	507	7	with	with	IN
cord-000372-wzwpyvll	507	8	Sm	sm	NN
cord-000372-wzwpyvll	507	9	proteins	protein	NNS
cord-000372-wzwpyvll	507	10	to	to	TO
cord-000372-wzwpyvll	507	11	form	form	VB
cord-000372-wzwpyvll	507	12	a	a	DT
cord-000372-wzwpyvll	507	13	heptameric	heptameric	JJ
cord-000372-wzwpyvll	507	14	ring	ring	NN
cord-000372-wzwpyvll	507	15	structure	structure	NN
cord-000372-wzwpyvll	507	16	in	in	IN
cord-000372-wzwpyvll	507	17	the	the	DT
cord-000372-wzwpyvll	507	18	presence	presence	NN
cord-000372-wzwpyvll	507	19	of	of	IN
cord-000372-wzwpyvll	507	20	U	U	NNP
cord-000372-wzwpyvll	507	21	snRNAs	snRNAs	NNP
cord-000372-wzwpyvll	507	22	[	[	-LRB-
cord-000372-wzwpyvll	507	23	211	211	CD
cord-000372-wzwpyvll	507	24	]	]	-RRB-
cord-000372-wzwpyvll	507	25	.	.	.
cord-000372-wzwpyvll	508	1	After	after	IN
cord-000372-wzwpyvll	508	2	Sm	Sm	NNP
cord-000372-wzwpyvll	508	3	core	core	NN
cord-000372-wzwpyvll	508	4	assembly	assembly	NN
cord-000372-wzwpyvll	508	5	,	,	,
cord-000372-wzwpyvll	508	6	the	the	DT
cord-000372-wzwpyvll	508	7	U	U	NNP
cord-000372-wzwpyvll	508	8	snRNPs	snRNPs	NNP
cord-000372-wzwpyvll	508	9	are	be	VBP
cord-000372-wzwpyvll	508	10	imported	import	VBN
cord-000372-wzwpyvll	508	11	to	to	IN
cord-000372-wzwpyvll	508	12	the	the	DT
cord-000372-wzwpyvll	508	13	nucleus	nucleus	NN
cord-000372-wzwpyvll	508	14	,	,	,
cord-000372-wzwpyvll	508	15	localizing	localize	VBG
cord-000372-wzwpyvll	508	16	in	in	IN
cord-000372-wzwpyvll	508	17	foci	foci	NN
cord-000372-wzwpyvll	508	18	known	know	VBN
cord-000372-wzwpyvll	508	19	as	as	IN
cord-000372-wzwpyvll	508	20	Cajal	Cajal	NNP
cord-000372-wzwpyvll	508	21	Bodies	Bodies	NNPS
cord-000372-wzwpyvll	508	22	,	,	,
cord-000372-wzwpyvll	508	23	where	where	WRB
cord-000372-wzwpyvll	508	24	further	further	JJ
cord-000372-wzwpyvll	508	25	maturation	maturation	NN
cord-000372-wzwpyvll	508	26	processes	process	NNS
cord-000372-wzwpyvll	508	27	take	take	VBP
cord-000372-wzwpyvll	508	28	place	place	NN
cord-000372-wzwpyvll	508	29	[	[	-LRB-
cord-000372-wzwpyvll	508	30	215	215	CD
cord-000372-wzwpyvll	508	31	]	]	-RRB-
cord-000372-wzwpyvll	508	32	.	.	.
cord-000372-wzwpyvll	509	1	Gemin-3	gemin-3	UH
cord-000372-wzwpyvll	509	2	,	,	,
cord-000372-wzwpyvll	509	3	one	one	CD
cord-000372-wzwpyvll	509	4	of	of	IN
cord-000372-wzwpyvll	509	5	the	the	DT
cord-000372-wzwpyvll	509	6	main	main	JJ
cord-000372-wzwpyvll	509	7	components	component	NNS
cord-000372-wzwpyvll	509	8	of	of	IN
cord-000372-wzwpyvll	509	9	SMN	SMN	NNP
cord-000372-wzwpyvll	509	10	complex	complex	NN
cord-000372-wzwpyvll	509	11	,	,	,
cord-000372-wzwpyvll	509	12	is	be	VBZ
cord-000372-wzwpyvll	509	13	cleaved	cleave	VBN
cord-000372-wzwpyvll	509	14	in	in	IN
cord-000372-wzwpyvll	509	15	PV	pv	NN
cord-000372-wzwpyvll	509	16	-	-	HYPH
cord-000372-wzwpyvll	509	17	infected	infect	VBN
cord-000372-wzwpyvll	509	18	HeLa	HeLa	NNP
cord-000372-wzwpyvll	509	19	cells	cell	NNS
cord-000372-wzwpyvll	509	20	leading	lead	VBG
cord-000372-wzwpyvll	509	21	to	to	IN
cord-000372-wzwpyvll	509	22	a	a	DT
cord-000372-wzwpyvll	509	23	50	50	CD
cord-000372-wzwpyvll	509	24	KDa	KDa	NNS
cord-000372-wzwpyvll	509	25	cleavage	cleavage	NN
cord-000372-wzwpyvll	509	26	product	product	NN
cord-000372-wzwpyvll	509	27	.	.	.
cord-000372-wzwpyvll	510	1	Scission	Scission	NNP
cord-000372-wzwpyvll	510	2	of	of	IN
cord-000372-wzwpyvll	510	3	Gemin-3	Gemin-3	NNP
cord-000372-wzwpyvll	510	4	negatively	negatively	RB
cord-000372-wzwpyvll	510	5	impacts	impact	VBZ
cord-000372-wzwpyvll	510	6	on	on	IN
cord-000372-wzwpyvll	510	7	the	the	DT
cord-000372-wzwpyvll	510	8	kinetics	kinetic	NNS
cord-000372-wzwpyvll	510	9	of	of	IN
cord-000372-wzwpyvll	510	10	Sm	Sm	NNP
cord-000372-wzwpyvll	510	11	core	core	NN
cord-000372-wzwpyvll	510	12	assembly	assembly	NN
cord-000372-wzwpyvll	510	13	,	,	,
cord-000372-wzwpyvll	510	14	which	which	WDT
cord-000372-wzwpyvll	510	15	is	be	VBZ
cord-000372-wzwpyvll	510	16	prevented	prevent	VBN
cord-000372-wzwpyvll	510	17	in	in	IN
cord-000372-wzwpyvll	510	18	presence	presence	NN
cord-000372-wzwpyvll	510	19	of	of	IN
cord-000372-wzwpyvll	510	20	inhibitors	inhibitor	NNS
cord-000372-wzwpyvll	510	21	of	of	IN
cord-000372-wzwpyvll	510	22	PV	PV	NNP
cord-000372-wzwpyvll	510	23	replication	replication	NN
cord-000372-wzwpyvll	510	24	[	[	-LRB-
cord-000372-wzwpyvll	510	25	216	216	CD
cord-000372-wzwpyvll	510	26	]	]	-RRB-
cord-000372-wzwpyvll	510	27	.	.	.
cord-000372-wzwpyvll	511	1	These	these	DT
cord-000372-wzwpyvll	511	2	results	result	NNS
cord-000372-wzwpyvll	511	3	indicated	indicate	VBD
cord-000372-wzwpyvll	511	4	that	that	IN
cord-000372-wzwpyvll	511	5	high	high	JJ
cord-000372-wzwpyvll	511	6	levels	level	NNS
cord-000372-wzwpyvll	511	7	of	of	IN
cord-000372-wzwpyvll	511	8	PV	pv	NN
cord-000372-wzwpyvll	511	9	proteins	protein	NNS
cord-000372-wzwpyvll	511	10	are	be	VBP
cord-000372-wzwpyvll	511	11	required	require	VBN
cord-000372-wzwpyvll	511	12	for	for	IN
cord-000372-wzwpyvll	511	13	this	this	DT
cord-000372-wzwpyvll	511	14	process	process	NN
cord-000372-wzwpyvll	511	15	to	to	TO
cord-000372-wzwpyvll	511	16	occur	occur	VB
cord-000372-wzwpyvll	511	17	,	,	,
cord-000372-wzwpyvll	511	18	as	as	IN
cord-000372-wzwpyvll	511	19	is	be	VBZ
cord-000372-wzwpyvll	511	20	the	the	DT
cord-000372-wzwpyvll	511	21	case	case	NN
cord-000372-wzwpyvll	511	22	of	of	IN
cord-000372-wzwpyvll	511	23	Nup153	nup153	CD
cord-000372-wzwpyvll	511	24	,	,	,
cord-000372-wzwpyvll	511	25	Nup62	Nup62	NNP
cord-000372-wzwpyvll	511	26	,	,	,
cord-000372-wzwpyvll	511	27	and	and	CC
cord-000372-wzwpyvll	511	28	eIF4GII	eif4gii	NN
cord-000372-wzwpyvll	511	29	,	,	,
cord-000372-wzwpyvll	511	30	[	[	-LRB-
cord-000372-wzwpyvll	511	31	16	16	CD
cord-000372-wzwpyvll	511	32	,	,	,
cord-000372-wzwpyvll	511	33	122	122	CD
cord-000372-wzwpyvll	511	34	]	]	-RRB-
cord-000372-wzwpyvll	511	35	.	.	.
cord-000372-wzwpyvll	512	1	PV	PV	NNP
cord-000372-wzwpyvll	512	2	2A	2a	NN
cord-000372-wzwpyvll	512	3	pro	pro	NNP
cord-000372-wzwpyvll	512	4	is	be	VBZ
cord-000372-wzwpyvll	512	5	able	able	JJ
cord-000372-wzwpyvll	512	6	to	to	TO
cord-000372-wzwpyvll	512	7	hydrolyze	hydrolyze	VB
cord-000372-wzwpyvll	512	8	purified	purify	VBN
cord-000372-wzwpyvll	512	9	Gemin-3	Gemin-3	NNP
cord-000372-wzwpyvll	512	10	in	in	IN
cord-000372-wzwpyvll	512	11	vitro	vitro	FW
cord-000372-wzwpyvll	512	12	,	,	,
cord-000372-wzwpyvll	512	13	rendering	render	VBG
cord-000372-wzwpyvll	512	14	a	a	DT
cord-000372-wzwpyvll	512	15	cleavage	cleavage	NN
cord-000372-wzwpyvll	512	16	product	product	NN
cord-000372-wzwpyvll	512	17	similar	similar	JJ
cord-000372-wzwpyvll	512	18	to	to	IN
cord-000372-wzwpyvll	512	19	that	that	DT
cord-000372-wzwpyvll	512	20	found	find	VBN
cord-000372-wzwpyvll	512	21	in	in	IN
cord-000372-wzwpyvll	512	22	PV	pv	NN
cord-000372-wzwpyvll	512	23	-	-	HYPH
cord-000372-wzwpyvll	512	24	infected	infect	VBN
cord-000372-wzwpyvll	512	25	HeLa	HeLa	NNP
cord-000372-wzwpyvll	512	26	cells	cell	NNS
cord-000372-wzwpyvll	512	27	[	[	-LRB-
cord-000372-wzwpyvll	512	28	216	216	CD
cord-000372-wzwpyvll	512	29	]	]	-RRB-
cord-000372-wzwpyvll	512	30	.	.	.
cord-000372-wzwpyvll	513	1	Only	only	RB
cord-000372-wzwpyvll	513	2	one	one	CD
cord-000372-wzwpyvll	513	3	potential	potential	JJ
cord-000372-wzwpyvll	513	4	2A	2a	CD
cord-000372-wzwpyvll	513	5	procleavage	procleavage	NN
cord-000372-wzwpyvll	513	6	site	site	NN
cord-000372-wzwpyvll	513	7	,	,	,
cord-000372-wzwpyvll	513	8	between	between	IN
cord-000372-wzwpyvll	513	9	the	the	DT
cord-000372-wzwpyvll	513	10	amino	amino	NN
cord-000372-wzwpyvll	513	11	acids	acid	NNS
cord-000372-wzwpyvll	513	12	Tyr	Tyr	NNP
cord-000372-wzwpyvll	513	13	462	462	CD
cord-000372-wzwpyvll	513	14	and	and	CC
cord-000372-wzwpyvll	513	15	Gly	Gly	NNP
cord-000372-wzwpyvll	513	16	463	463	CD
cord-000372-wzwpyvll	513	17	(	(	-LRB-
cord-000372-wzwpyvll	513	18	VHTYG	VHTYG	NNP
cord-000372-wzwpyvll	513	19	)	)	-RRB-
cord-000372-wzwpyvll	513	20	,	,	,
cord-000372-wzwpyvll	513	21	was	be	VBD
cord-000372-wzwpyvll	513	22	found	find	VBN
cord-000372-wzwpyvll	513	23	in	in	IN
cord-000372-wzwpyvll	513	24	this	this	DT
cord-000372-wzwpyvll	513	25	SMN	SMN	NNP
cord-000372-wzwpyvll	513	26	complex	complex	JJ
cord-000372-wzwpyvll	513	27	component	component	NN
cord-000372-wzwpyvll	513	28	.	.	.
cord-000372-wzwpyvll	514	1	Proteolysis	Proteolysis	NNP
cord-000372-wzwpyvll	514	2	of	of	IN
cord-000372-wzwpyvll	514	3	Gemin-3	Gemin-3	NNP
cord-000372-wzwpyvll	514	4	at	at	IN
cord-000372-wzwpyvll	514	5	this	this	DT
cord-000372-wzwpyvll	514	6	position	position	NN
cord-000372-wzwpyvll	514	7	would	would	MD
cord-000372-wzwpyvll	514	8	render	render	VB
cord-000372-wzwpyvll	514	9	two	two	CD
cord-000372-wzwpyvll	514	10	cleavage	cleavage	NN
cord-000372-wzwpyvll	514	11	products	product	NNS
cord-000372-wzwpyvll	514	12	of	of	IN
cord-000372-wzwpyvll	514	13	about	about	RB
cord-000372-wzwpyvll	514	14	50	50	CD
cord-000372-wzwpyvll	514	15	-	-	SYM
cord-000372-wzwpyvll	514	16	30	30	CD
cord-000372-wzwpyvll	514	17	KDa	KDa	NNS
cord-000372-wzwpyvll	514	18	,	,	,
cord-000372-wzwpyvll	514	19	in	in	IN
cord-000372-wzwpyvll	514	20	agreement	agreement	NN
cord-000372-wzwpyvll	514	21	with	with	IN
cord-000372-wzwpyvll	514	22	the	the	DT
cord-000372-wzwpyvll	514	23	polypeptide	polypeptide	NN
cord-000372-wzwpyvll	514	24	of	of	IN
cord-000372-wzwpyvll	514	25	about	about	RB
cord-000372-wzwpyvll	514	26	50	50	CD
cord-000372-wzwpyvll	514	27	KDa	KDa	NNS
cord-000372-wzwpyvll	514	28	found	find	VBN
cord-000372-wzwpyvll	514	29	in	in	IN
cord-000372-wzwpyvll	514	30	PV	pv	NN
cord-000372-wzwpyvll	514	31	-	-	HYPH
cord-000372-wzwpyvll	514	32	infected	infect	VBN
cord-000372-wzwpyvll	514	33	and	and	CC
cord-000372-wzwpyvll	514	34	2A	2a	CD
cord-000372-wzwpyvll	514	35	pro	pro	JJ
cord-000372-wzwpyvll	514	36	-expressing	-expressing	NN
cord-000372-wzwpyvll	514	37	cells	cell	NNS
cord-000372-wzwpyvll	514	38	.	.	.
cord-000372-wzwpyvll	515	1	In	in	IN
cord-000372-wzwpyvll	515	2	addition	addition	NN
cord-000372-wzwpyvll	515	3	,	,	,
cord-000372-wzwpyvll	515	4	G463E	g463e	NN
cord-000372-wzwpyvll	515	5	mutation	mutation	NN
cord-000372-wzwpyvll	515	6	avoids	avoid	VBZ
cord-000372-wzwpyvll	515	7	direct	direct	JJ
cord-000372-wzwpyvll	515	8	hydrolysis	hydrolysis	NN
cord-000372-wzwpyvll	515	9	of	of	IN
cord-000372-wzwpyvll	515	10	Gemin-3	Gemin-3	NNP
cord-000372-wzwpyvll	515	11	exerted	exert	VBN
cord-000372-wzwpyvll	515	12	by	by	IN
cord-000372-wzwpyvll	515	13	PV	PV	NNP
cord-000372-wzwpyvll	515	14	2A	2a	CD
cord-000372-wzwpyvll	515	15	pro	pro	JJ
cord-000372-wzwpyvll	515	16	in	in	IN
cord-000372-wzwpyvll	515	17	vivo	vivo	NN
cord-000372-wzwpyvll	515	18	and	and	CC
cord-000372-wzwpyvll	515	19	in	in	IN
cord-000372-wzwpyvll	515	20	vitro	vitro	FW
cord-000372-wzwpyvll	515	21	[	[	-LRB-
cord-000372-wzwpyvll	515	22	216	216	CD
cord-000372-wzwpyvll	515	23	]	]	-RRB-
cord-000372-wzwpyvll	515	24	.	.	.
cord-000372-wzwpyvll	516	1	Taken	take	VBN
cord-000372-wzwpyvll	516	2	together	together	RB
cord-000372-wzwpyvll	516	3	,	,	,
cord-000372-wzwpyvll	516	4	these	these	DT
cord-000372-wzwpyvll	516	5	findings	finding	NNS
cord-000372-wzwpyvll	516	6	support	support	VBP
cord-000372-wzwpyvll	516	7	the	the	DT
cord-000372-wzwpyvll	516	8	notion	notion	NN
cord-000372-wzwpyvll	516	9	that	that	IN
cord-000372-wzwpyvll	516	10	VHTYG	VHTYG	NNP
cord-000372-wzwpyvll	516	11	is	be	VBZ
cord-000372-wzwpyvll	516	12	the	the	DT
cord-000372-wzwpyvll	516	13	cleavage	cleavage	NN
cord-000372-wzwpyvll	516	14	site	site	NN
cord-000372-wzwpyvll	516	15	for	for	IN
cord-000372-wzwpyvll	516	16	PV	PV	NNP
cord-000372-wzwpyvll	516	17	2A	2a	CD
cord-000372-wzwpyvll	516	18	pro	pro	JJ
cord-000372-wzwpyvll	516	19	in	in	IN
cord-000372-wzwpyvll	516	20	Gemin-3	Gemin-3	NNP
cord-000372-wzwpyvll	516	21	.	.	.
cord-000372-wzwpyvll	517	1	Although	although	IN
cord-000372-wzwpyvll	517	2	hydrolysis	hydrolysis	NN
cord-000372-wzwpyvll	517	3	of	of	IN
cord-000372-wzwpyvll	517	4	Gemin-3	Gemin-3	NNP
cord-000372-wzwpyvll	517	5	is	be	VBZ
cord-000372-wzwpyvll	517	6	exerted	exert	VBN
cord-000372-wzwpyvll	517	7	in	in	IN
cord-000372-wzwpyvll	517	8	cells	cell	NNS
cord-000372-wzwpyvll	517	9	transfected	transfecte	VBN
cord-000372-wzwpyvll	517	10	with	with	IN
cord-000372-wzwpyvll	517	11	plasmid	plasmid	NN
cord-000372-wzwpyvll	517	12	encoding	encode	VBG
cord-000372-wzwpyvll	517	13	PV	PV	NNP
cord-000372-wzwpyvll	517	14	2A	2a	CD
cord-000372-wzwpyvll	517	15	pro	pro	NNP
cord-000372-wzwpyvll	517	16	,	,	,
cord-000372-wzwpyvll	517	17	it	-PRON-	PRP
cord-000372-wzwpyvll	517	18	does	do	VBZ
cord-000372-wzwpyvll	517	19	not	not	RB
cord-000372-wzwpyvll	517	20	take	take	VB
cord-000372-wzwpyvll	517	21	place	place	NN
cord-000372-wzwpyvll	517	22	when	when	WRB
cord-000372-wzwpyvll	517	23	this	this	DT
cord-000372-wzwpyvll	517	24	protease	protease	NN
cord-000372-wzwpyvll	517	25	is	be	VBZ
cord-000372-wzwpyvll	517	26	expressed	express	VBN
cord-000372-wzwpyvll	517	27	from	from	IN
cord-000372-wzwpyvll	517	28	exogenous	exogenous	JJ
cord-000372-wzwpyvll	517	29	mRNAs	mRNAs	NNPS
cord-000372-wzwpyvll	517	30	;	;	:
cord-000372-wzwpyvll	517	31	contrary	contrary	RB
cord-000372-wzwpyvll	517	32	to	to	IN
cord-000372-wzwpyvll	517	33	that	that	DT
cord-000372-wzwpyvll	517	34	found	find	VBN
cord-000372-wzwpyvll	517	35	with	with	IN
cord-000372-wzwpyvll	517	36	eIF4GI	eIF4GI	NNS
cord-000372-wzwpyvll	517	37	,	,	,
cord-000372-wzwpyvll	517	38	eIF4GII	eif4gii	FW
cord-000372-wzwpyvll	517	39	,	,	,
cord-000372-wzwpyvll	517	40	Nup98	Nup98	NNP
cord-000372-wzwpyvll	517	41	,	,	,
cord-000372-wzwpyvll	517	42	Nup153	nup153	CD
cord-000372-wzwpyvll	517	43	and	and	CC
cord-000372-wzwpyvll	517	44	Nup62	Nup62	NNP
cord-000372-wzwpyvll	517	45	[	[	-LRB-
cord-000372-wzwpyvll	517	46	17	17	CD
cord-000372-wzwpyvll	517	47	]	]	-RRB-
cord-000372-wzwpyvll	517	48	(	(	-LRB-
cord-000372-wzwpyvll	517	49	and	and	CC
cord-000372-wzwpyvll	517	50	unpublished	unpublished	JJ
cord-000372-wzwpyvll	517	51	data	datum	NNS
cord-000372-wzwpyvll	517	52	)	)	-RRB-
cord-000372-wzwpyvll	517	53	.	.	.
cord-000372-wzwpyvll	518	1	A	a	DT
cord-000372-wzwpyvll	518	2	probable	probable	JJ
cord-000372-wzwpyvll	518	3	explanation	explanation	NN
cord-000372-wzwpyvll	518	4	for	for	IN
cord-000372-wzwpyvll	518	5	this	this	DT
cord-000372-wzwpyvll	518	6	difference	difference	NN
cord-000372-wzwpyvll	518	7	is	be	VBZ
cord-000372-wzwpyvll	518	8	that	that	IN
cord-000372-wzwpyvll	518	9	PV	PV	NNP
cord-000372-wzwpyvll	518	10	2A	2a	NN
cord-000372-wzwpyvll	518	11	pro	pro	NNP
cord-000372-wzwpyvll	518	12	is	be	VBZ
cord-000372-wzwpyvll	518	13	expressed	express	VBN
cord-000372-wzwpyvll	518	14	at	at	IN
cord-000372-wzwpyvll	518	15	lower	low	JJR
cord-000372-wzwpyvll	518	16	levels	level	NNS
cord-000372-wzwpyvll	518	17	from	from	IN
cord-000372-wzwpyvll	518	18	transfected	transfecte	VBN
cord-000372-wzwpyvll	518	19	mRNAs	mRNAs	NNPS
cord-000372-wzwpyvll	518	20	than	than	IN
cord-000372-wzwpyvll	518	21	from	from	IN
cord-000372-wzwpyvll	518	22	plasmids	plasmid	NNS
cord-000372-wzwpyvll	518	23	[	[	-LRB-
cord-000372-wzwpyvll	518	24	95	95	CD
cord-000372-wzwpyvll	518	25	]	]	-RRB-
cord-000372-wzwpyvll	519	1	(	(	-LRB-
cord-000372-wzwpyvll	519	2	Castello	Castello	NNP
cord-000372-wzwpyvll	519	3	et	et	FW
cord-000372-wzwpyvll	519	4	al	al	NNP
cord-000372-wzwpyvll	519	5	.	.	NNP
cord-000372-wzwpyvll	519	6	,	,	,
cord-000372-wzwpyvll	519	7	2006	2006	CD
cord-000372-wzwpyvll	519	8	)	)	-RRB-
cord-000372-wzwpyvll	519	9	.	.	.
cord-000372-wzwpyvll	520	1	Thus	thus	RB
cord-000372-wzwpyvll	520	2	,	,	,
cord-000372-wzwpyvll	520	3	Gemin-3	Gemin-3	NNP
cord-000372-wzwpyvll	520	4	cleavage	cleavage	NN
cord-000372-wzwpyvll	520	5	may	may	MD
cord-000372-wzwpyvll	520	6	be	be	VB
cord-000372-wzwpyvll	520	7	a	a	DT
cord-000372-wzwpyvll	520	8	very	very	RB
cord-000372-wzwpyvll	520	9	late	late	JJ
cord-000372-wzwpyvll	520	10	event	event	NN
cord-000372-wzwpyvll	520	11	in	in	IN
cord-000372-wzwpyvll	520	12	PV	pv	NN
cord-000372-wzwpyvll	520	13	-	-	HYPH
cord-000372-wzwpyvll	520	14	infected	infect	VBN
cord-000372-wzwpyvll	520	15	cells	cell	NNS
cord-000372-wzwpyvll	520	16	because	because	IN
cord-000372-wzwpyvll	520	17	it	-PRON-	PRP
cord-000372-wzwpyvll	520	18	requires	require	VBZ
cord-000372-wzwpyvll	520	19	expression	expression	NN
cord-000372-wzwpyvll	520	20	of	of	IN
cord-000372-wzwpyvll	520	21	high	high	JJ
cord-000372-wzwpyvll	520	22	amounts	amount	NNS
cord-000372-wzwpyvll	520	23	of	of	IN
cord-000372-wzwpyvll	520	24	PV	PV	NNP
cord-000372-wzwpyvll	520	25	2A	2a	NN
cord-000372-wzwpyvll	520	26	pro	pro	JJ
cord-000372-wzwpyvll	520	27	.	.	.
cord-000372-wzwpyvll	521	1	Gemin-3	Gemin-3	NNP
cord-000372-wzwpyvll	522	1	hydrolysis	hydrolysis	NN
cord-000372-wzwpyvll	522	2	may	may	MD
cord-000372-wzwpyvll	522	3	directly	directly	RB
cord-000372-wzwpyvll	522	4	impact	impact	VB
cord-000372-wzwpyvll	522	5	on	on	IN
cord-000372-wzwpyvll	522	6	pre	pre	JJ
cord-000372-wzwpyvll	522	7	-	-	JJ
cord-000372-wzwpyvll	522	8	mRNA	mrna	JJ
cord-000372-wzwpyvll	522	9	splicing	splicing	NN
cord-000372-wzwpyvll	522	10	since	since	IN
cord-000372-wzwpyvll	522	11	this	this	DT
cord-000372-wzwpyvll	522	12	event	event	NN
cord-000372-wzwpyvll	522	13	reduces	reduce	VBZ
cord-000372-wzwpyvll	522	14	the	the	DT
cord-000372-wzwpyvll	522	15	availability	availability	NN
cord-000372-wzwpyvll	522	16	of	of	IN
cord-000372-wzwpyvll	522	17	SMN	SMN	NNP
cord-000372-wzwpyvll	522	18	complexes	complex	NNS
cord-000372-wzwpyvll	522	19	,	,	,
cord-000372-wzwpyvll	522	20	which	which	WDT
cord-000372-wzwpyvll	522	21	is	be	VBZ
cord-000372-wzwpyvll	522	22	involved	involve	VBN
cord-000372-wzwpyvll	522	23	in	in	IN
cord-000372-wzwpyvll	522	24	U	U	NNP
cord-000372-wzwpyvll	522	25	snRNPs	snrnps	JJ
cord-000372-wzwpyvll	522	26	biogenesis	biogenesis	NN
cord-000372-wzwpyvll	522	27	.	.	.
cord-000372-wzwpyvll	523	1	Nevertheless	nevertheless	RB
cord-000372-wzwpyvll	523	2	,	,	,
cord-000372-wzwpyvll	523	3	Alstead	Alstead	NNP
cord-000372-wzwpyvll	523	4	and	and	CC
cord-000372-wzwpyvll	523	5	colleagues	colleague	NNS
cord-000372-wzwpyvll	523	6	could	could	MD
cord-000372-wzwpyvll	523	7	not	not	RB
cord-000372-wzwpyvll	523	8	detect	detect	VB
cord-000372-wzwpyvll	523	9	any	any	DT
cord-000372-wzwpyvll	523	10	apparent	apparent	JJ
cord-000372-wzwpyvll	523	11	effect	effect	NN
cord-000372-wzwpyvll	523	12	of	of	IN
cord-000372-wzwpyvll	523	13	Gemin-3	Gemin-3	NNP
cord-000372-wzwpyvll	523	14	proteolysis	proteolysis	NN
cord-000372-wzwpyvll	523	15	in	in	IN
cord-000372-wzwpyvll	523	16	splicing	splicing	NN
cord-000372-wzwpyvll	523	17	of	of	IN
cord-000372-wzwpyvll	523	18	cellular	cellular	JJ
cord-000372-wzwpyvll	523	19	pre	pre	NNS
cord-000372-wzwpyvll	523	20	-	-	JJ
cord-000372-wzwpyvll	523	21	mRNAs	mrnas	JJ
cord-000372-wzwpyvll	523	22	[	[	-LRB-
cord-000372-wzwpyvll	523	23	216	216	CD
cord-000372-wzwpyvll	523	24	]	]	-RRB-
cord-000372-wzwpyvll	523	25	.	.	.
cord-000372-wzwpyvll	524	1	Therefore	therefore	RB
cord-000372-wzwpyvll	524	2	,	,	,
cord-000372-wzwpyvll	524	3	the	the	DT
cord-000372-wzwpyvll	524	4	physiological	physiological	JJ
cord-000372-wzwpyvll	524	5	relevance	relevance	NN
cord-000372-wzwpyvll	524	6	of	of	IN
cord-000372-wzwpyvll	524	7	Gemin-3	Gemin-3	NNP
cord-000372-wzwpyvll	524	8	cleavage	cleavage	NN
cord-000372-wzwpyvll	524	9	in	in	IN
cord-000372-wzwpyvll	524	10	PV	pv	NN
cord-000372-wzwpyvll	524	11	biological	biological	JJ
cord-000372-wzwpyvll	524	12	cycle	cycle	NN
cord-000372-wzwpyvll	524	13	remains	remain	VBZ
cord-000372-wzwpyvll	524	14	unknown	unknown	JJ
cord-000372-wzwpyvll	524	15	.	.	.
cord-000372-wzwpyvll	525	1	In	in	IN
cord-000372-wzwpyvll	525	2	addition	addition	NN
cord-000372-wzwpyvll	525	3	to	to	IN
cord-000372-wzwpyvll	525	4	eIFs	eifs	NN
cord-000372-wzwpyvll	525	5	,	,	,
cord-000372-wzwpyvll	525	6	Nups	Nups	NNP
cord-000372-wzwpyvll	525	7	and	and	CC
cord-000372-wzwpyvll	525	8	proteins	protein	NNS
cord-000372-wzwpyvll	525	9	from	from	IN
cord-000372-wzwpyvll	525	10	SMN	SMN	NNP
cord-000372-wzwpyvll	525	11	complex	complex	NN
cord-000372-wzwpyvll	525	12	,	,	,
cord-000372-wzwpyvll	525	13	PV	PV	NNP
cord-000372-wzwpyvll	525	14	2A	2a	NN
cord-000372-wzwpyvll	525	15	pro	pro	NNP
cord-000372-wzwpyvll	525	16	is	be	VBZ
cord-000372-wzwpyvll	525	17	able	able	JJ
cord-000372-wzwpyvll	525	18	to	to	TO
cord-000372-wzwpyvll	525	19	cleave	cleave	VB
cord-000372-wzwpyvll	525	20	proteins	protein	NNS
cord-000372-wzwpyvll	525	21	involved	involve	VBN
cord-000372-wzwpyvll	525	22	in	in	IN
cord-000372-wzwpyvll	525	23	other	other	JJ
cord-000372-wzwpyvll	525	24	cellular	cellular	JJ
cord-000372-wzwpyvll	525	25	processes	process	NNS
cord-000372-wzwpyvll	525	26	,	,	,
cord-000372-wzwpyvll	525	27	such	such	JJ
cord-000372-wzwpyvll	525	28	as	as	IN
cord-000372-wzwpyvll	525	29	transcription	transcription	NN
cord-000372-wzwpyvll	525	30	.	.	.
cord-000372-wzwpyvll	526	1	TBP	TBP	NNP
cord-000372-wzwpyvll	526	2	is	be	VBZ
cord-000372-wzwpyvll	526	3	cleaved	cleave	VBN
cord-000372-wzwpyvll	526	4	by	by	IN
cord-000372-wzwpyvll	526	5	PV	PV	NNP
cord-000372-wzwpyvll	526	6	2A	2a	NN
cord-000372-wzwpyvll	526	7	pro	pro	NN
cord-000372-wzwpyvll	526	8	between	between	IN
cord-000372-wzwpyvll	526	9	amino	amino	JJ
cord-000372-wzwpyvll	526	10	acids	acid	NNS
cord-000372-wzwpyvll	526	11	Tyr	Tyr	NNP
cord-000372-wzwpyvll	526	12	34	34	CD
cord-000372-wzwpyvll	526	13	and	and	CC
cord-000372-wzwpyvll	526	14	Gly	Gly	NNP
cord-000372-wzwpyvll	526	15	35	35	CD
cord-000372-wzwpyvll	526	16	in	in	IN
cord-000372-wzwpyvll	526	17	vitro	vitro	FW
cord-000372-wzwpyvll	526	18	,	,	,
cord-000372-wzwpyvll	526	19	although	although	IN
cord-000372-wzwpyvll	526	20	this	this	DT
cord-000372-wzwpyvll	526	21	cleavage	cleavage	NN
cord-000372-wzwpyvll	526	22	only	only	RB
cord-000372-wzwpyvll	526	23	removes	remove	VBZ
cord-000372-wzwpyvll	526	24	the	the	DT
cord-000372-wzwpyvll	526	25	first	first	JJ
cord-000372-wzwpyvll	526	26	34	34	CD
cord-000372-wzwpyvll	526	27	aa	aa	NN
cord-000372-wzwpyvll	526	28	located	locate	VBN
cord-000372-wzwpyvll	526	29	at	at	IN
cord-000372-wzwpyvll	526	30	the	the	DT
cord-000372-wzwpyvll	526	31	N	n	CD
cord-000372-wzwpyvll	526	32	-	-	HYPH
cord-000372-wzwpyvll	526	33	terminus	terminus	NN
cord-000372-wzwpyvll	526	34	and	and	CC
cord-000372-wzwpyvll	526	35	does	do	VBZ
cord-000372-wzwpyvll	526	36	not	not	RB
cord-000372-wzwpyvll	526	37	inhibit	inhibit	VB
cord-000372-wzwpyvll	526	38	transcription	transcription	NN
cord-000372-wzwpyvll	526	39	carried	carry	VBN
cord-000372-wzwpyvll	526	40	out	out	RP
cord-000372-wzwpyvll	526	41	by	by	IN
cord-000372-wzwpyvll	526	42	RNA	RNA	NNP
cord-000372-wzwpyvll	526	43	Polymerase	Polymerase	NNP
cord-000372-wzwpyvll	526	44	II	II	NNP
cord-000372-wzwpyvll	526	45	[	[	-LRB-
cord-000372-wzwpyvll	526	46	217	217	CD
cord-000372-wzwpyvll	526	47	,	,	,
cord-000372-wzwpyvll	526	48	218	218	CD
cord-000372-wzwpyvll	526	49	]	]	-RRB-
cord-000372-wzwpyvll	526	50	.	.	.
cord-000372-wzwpyvll	527	1	These	these	DT
cord-000372-wzwpyvll	527	2	findings	finding	NNS
cord-000372-wzwpyvll	527	3	are	be	VBP
cord-000372-wzwpyvll	527	4	in	in	IN
cord-000372-wzwpyvll	527	5	agreement	agreement	NN
cord-000372-wzwpyvll	527	6	with	with	IN
cord-000372-wzwpyvll	527	7	the	the	DT
cord-000372-wzwpyvll	527	8	fact	fact	NN
cord-000372-wzwpyvll	527	9	that	that	IN
cord-000372-wzwpyvll	527	10	host	host	NN
cord-000372-wzwpyvll	527	11	mRNA	mrna	NN
cord-000372-wzwpyvll	527	12	transcription	transcription	NN
cord-000372-wzwpyvll	527	13	takes	take	VBZ
cord-000372-wzwpyvll	527	14	place	place	NN
cord-000372-wzwpyvll	527	15	in	in	IN
cord-000372-wzwpyvll	527	16	2A	2a	CD
cord-000372-wzwpyvll	527	17	pro	pro	JJ
cord-000372-wzwpyvll	527	18	-expressing	-expressing	NN
cord-000372-wzwpyvll	527	19	cells	cell	NNS
cord-000372-wzwpyvll	527	20	when	when	WRB
cord-000372-wzwpyvll	527	21	both	both	DT
cord-000372-wzwpyvll	527	22	translation	translation	NN
cord-000372-wzwpyvll	527	23	and	and	CC
cord-000372-wzwpyvll	527	24	RNA	RNA	NNP
cord-000372-wzwpyvll	527	25	nuclear	nuclear	JJ
cord-000372-wzwpyvll	527	26	export	export	NN
cord-000372-wzwpyvll	527	27	are	be	VBP
cord-000372-wzwpyvll	527	28	inhibited	inhibit	VBN
cord-000372-wzwpyvll	527	29	,	,	,
cord-000372-wzwpyvll	527	30	upon	upon	IN
cord-000372-wzwpyvll	527	31	cleavage	cleavage	NN
cord-000372-wzwpyvll	527	32	of	of	IN
cord-000372-wzwpyvll	527	33	eIF4	eIF4	NNP
cord-000372-wzwpyvll	527	34	G	G	NNP
cord-000372-wzwpyvll	527	35	and	and	CC
cord-000372-wzwpyvll	527	36	Nups	Nups	NNP
cord-000372-wzwpyvll	527	37	[	[	-LRB-
cord-000372-wzwpyvll	527	38	17	17	CD
cord-000372-wzwpyvll	527	39	]	]	-RRB-
cord-000372-wzwpyvll	527	40	.	.	.
cord-000372-wzwpyvll	528	1	One	one	CD
cord-000372-wzwpyvll	528	2	attractive	attractive	JJ
cord-000372-wzwpyvll	528	3	hypothesis	hypothesis	NN
cord-000372-wzwpyvll	528	4	is	be	VBZ
cord-000372-wzwpyvll	528	5	that	that	IN
cord-000372-wzwpyvll	528	6	PV	PV	NNP
cord-000372-wzwpyvll	528	7	2A	2a	NN
cord-000372-wzwpyvll	528	8	pro	pro	JJ
cord-000372-wzwpyvll	528	9	could	could	MD
cord-000372-wzwpyvll	528	10	cleave	cleave	VB
cord-000372-wzwpyvll	528	11	specific	specific	JJ
cord-000372-wzwpyvll	528	12	initiation	initiation	NN
cord-000372-wzwpyvll	528	13	factors	factor	NNS
cord-000372-wzwpyvll	528	14	affecting	affect	VBG
cord-000372-wzwpyvll	528	15	specific	specific	JJ
cord-000372-wzwpyvll	528	16	rather	rather	RB
cord-000372-wzwpyvll	528	17	than	than	IN
cord-000372-wzwpyvll	528	18	general	general	JJ
cord-000372-wzwpyvll	528	19	mRNA	mRNA	NNP
cord-000372-wzwpyvll	528	20	transcription	transcription	NN
cord-000372-wzwpyvll	528	21	in	in	IN
cord-000372-wzwpyvll	528	22	order	order	NN
cord-000372-wzwpyvll	528	23	to	to	TO
cord-000372-wzwpyvll	528	24	modulate	modulate	VB
cord-000372-wzwpyvll	528	25	host	host	NN
cord-000372-wzwpyvll	528	26	-	-	HYPH
cord-000372-wzwpyvll	528	27	cell	cell	NN
cord-000372-wzwpyvll	528	28	response	response	NN
cord-000372-wzwpyvll	528	29	to	to	IN
cord-000372-wzwpyvll	528	30	viral	viral	JJ
cord-000372-wzwpyvll	528	31	infection	infection	NN
cord-000372-wzwpyvll	528	32	.	.	.
cord-000372-wzwpyvll	529	1	Further	further	JJ
cord-000372-wzwpyvll	529	2	studies	study	NNS
cord-000372-wzwpyvll	529	3	in	in	IN
cord-000372-wzwpyvll	529	4	this	this	DT
cord-000372-wzwpyvll	529	5	direction	direction	NN
cord-000372-wzwpyvll	529	6	can	can	MD
cord-000372-wzwpyvll	529	7	be	be	VB
cord-000372-wzwpyvll	529	8	carried	carry	VBN
cord-000372-wzwpyvll	529	9	out	out	RP
cord-000372-wzwpyvll	529	10	using	use	VBG
cord-000372-wzwpyvll	529	11	microarray	microarray	NN
cord-000372-wzwpyvll	529	12	platforms	platform	NNS
cord-000372-wzwpyvll	529	13	to	to	TO
cord-000372-wzwpyvll	529	14	detect	detect	VB
cord-000372-wzwpyvll	529	15	precise	precise	JJ
cord-000372-wzwpyvll	529	16	alterations	alteration	NNS
cord-000372-wzwpyvll	529	17	in	in	IN
cord-000372-wzwpyvll	529	18	cellular	cellular	JJ
cord-000372-wzwpyvll	529	19	transcriptome	transcriptome	NN
cord-000372-wzwpyvll	529	20	after	after	IN
cord-000372-wzwpyvll	529	21	PV	pv	NN
cord-000372-wzwpyvll	529	22	-	-	HYPH
cord-000372-wzwpyvll	529	23	infection	infection	NN
cord-000372-wzwpyvll	529	24	or	or	CC
cord-000372-wzwpyvll	529	25	2A	2a	CD
cord-000372-wzwpyvll	529	26	pro	pro	JJ
cord-000372-wzwpyvll	529	27	expression	expression	NN
cord-000372-wzwpyvll	529	28	.	.	.
cord-000372-wzwpyvll	530	1	These	these	DT
cord-000372-wzwpyvll	530	2	studies	study	NNS
cord-000372-wzwpyvll	530	3	could	could	MD
cord-000372-wzwpyvll	530	4	be	be	VB
cord-000372-wzwpyvll	530	5	complemented	complement	VBN
cord-000372-wzwpyvll	530	6	by	by	IN
cord-000372-wzwpyvll	530	7	screening	screening	NN
cord-000372-wzwpyvll	530	8	for	for	IN
cord-000372-wzwpyvll	530	9	new	new	JJ
cord-000372-wzwpyvll	530	10	host	host	NN
cord-000372-wzwpyvll	530	11	factors	factor	NNS
cord-000372-wzwpyvll	530	12	cleaved	cleave	VBN
cord-000372-wzwpyvll	530	13	by	by	IN
cord-000372-wzwpyvll	530	14	PV	PV	NNP
cord-000372-wzwpyvll	530	15	2A	2a	NN
cord-000372-wzwpyvll	530	16	pro	pro	JJ
cord-000372-wzwpyvll	530	17	using	use	VBG
cord-000372-wzwpyvll	530	18	different	different	JJ
cord-000372-wzwpyvll	530	19	in	in	IN
cord-000372-wzwpyvll	530	20	silico	silico	NN
cord-000372-wzwpyvll	530	21	and	and	CC
cord-000372-wzwpyvll	530	22	experimental	experimental	JJ
cord-000372-wzwpyvll	530	23	approaches	approach	NNS
cord-000372-wzwpyvll	530	24	.	.	.
cord-000372-wzwpyvll	531	1	The	the	DT
cord-000372-wzwpyvll	531	2	study	study	NN
cord-000372-wzwpyvll	531	3	of	of	IN
cord-000372-wzwpyvll	531	4	viral	viral	JJ
cord-000372-wzwpyvll	531	5	proteases	protease	NNS
cord-000372-wzwpyvll	531	6	is	be	VBZ
cord-000372-wzwpyvll	531	7	crucial	crucial	JJ
cord-000372-wzwpyvll	531	8	to	to	TO
cord-000372-wzwpyvll	531	9	understand	understand	VB
cord-000372-wzwpyvll	531	10	the	the	DT
cord-000372-wzwpyvll	531	11	mechanism	mechanism	NN
cord-000372-wzwpyvll	531	12	used	use	VBN
cord-000372-wzwpyvll	531	13	by	by	IN
cord-000372-wzwpyvll	531	14	animal	animal	NN
cord-000372-wzwpyvll	531	15	viruses	virus	NNS
cord-000372-wzwpyvll	531	16	to	to	TO
cord-000372-wzwpyvll	531	17	replicate	replicate	VB
cord-000372-wzwpyvll	531	18	their	-PRON-	PRP$
cord-000372-wzwpyvll	531	19	genomes	genome	NNS
cord-000372-wzwpyvll	531	20	and	and	CC
cord-000372-wzwpyvll	531	21	to	to	TO
cord-000372-wzwpyvll	531	22	translate	translate	VB
cord-000372-wzwpyvll	531	23	viral	viral	JJ
cord-000372-wzwpyvll	531	24	mRNAs	mrnas	RB
cord-000372-wzwpyvll	531	25	at	at	IN
cord-000372-wzwpyvll	531	26	the	the	DT
cord-000372-wzwpyvll	531	27	molecular	molecular	JJ
cord-000372-wzwpyvll	531	28	level	level	NN
cord-000372-wzwpyvll	531	29	.	.	.
cord-000372-wzwpyvll	532	1	In	in	IN
cord-000372-wzwpyvll	532	2	addition	addition	NN
cord-000372-wzwpyvll	532	3	,	,	,
cord-000372-wzwpyvll	532	4	we	-PRON-	PRP
cord-000372-wzwpyvll	532	5	wish	wish	VBP
cord-000372-wzwpyvll	532	6	to	to	TO
cord-000372-wzwpyvll	532	7	draw	draw	VB
cord-000372-wzwpyvll	532	8	attention	attention	NN
cord-000372-wzwpyvll	532	9	to	to	IN
cord-000372-wzwpyvll	532	10	the	the	DT
cord-000372-wzwpyvll	532	11	concept	concept	NN
cord-000372-wzwpyvll	532	12	that	that	IN
cord-000372-wzwpyvll	532	13	viral	viral	JJ
cord-000372-wzwpyvll	532	14	proteases	protease	NNS
cord-000372-wzwpyvll	532	15	can	can	MD
cord-000372-wzwpyvll	532	16	be	be	VB
cord-000372-wzwpyvll	532	17	used	use	VBN
cord-000372-wzwpyvll	532	18	as	as	IN
cord-000372-wzwpyvll	532	19	tools	tool	NNS
cord-000372-wzwpyvll	532	20	to	to	TO
cord-000372-wzwpyvll	532	21	reveal	reveal	VB
cord-000372-wzwpyvll	532	22	the	the	DT
cord-000372-wzwpyvll	532	23	exact	exact	JJ
cord-000372-wzwpyvll	532	24	functioning	functioning	NN
cord-000372-wzwpyvll	532	25	of	of	IN
cord-000372-wzwpyvll	532	26	their	-PRON-	PRP$
cord-000372-wzwpyvll	532	27	target	target	NN
cord-000372-wzwpyvll	532	28	cellular	cellular	JJ
cord-000372-wzwpyvll	532	29	proteins	protein	NNS
cord-000372-wzwpyvll	532	30	.	.	.
cord-000372-wzwpyvll	533	1	In	in	IN
cord-000372-wzwpyvll	533	2	this	this	DT
cord-000372-wzwpyvll	533	3	regard	regard	NN
cord-000372-wzwpyvll	533	4	,	,	,
cord-000372-wzwpyvll	533	5	PV	PV	NNP
cord-000372-wzwpyvll	533	6	2A	2a	NN
cord-000372-wzwpyvll	533	7	pro	pro	NNP
cord-000372-wzwpyvll	533	8	has	have	VBZ
cord-000372-wzwpyvll	533	9	been	be	VBN
cord-000372-wzwpyvll	533	10	very	very	RB
cord-000372-wzwpyvll	533	11	useful	useful	JJ
cord-000372-wzwpyvll	533	12	for	for	IN
cord-000372-wzwpyvll	533	13	examining	examine	VBG
cord-000372-wzwpyvll	533	14	the	the	DT
cord-000372-wzwpyvll	533	15	requirements	requirement	NNS
cord-000372-wzwpyvll	533	16	for	for	IN
cord-000372-wzwpyvll	533	17	eIF4	eif4	IN
cord-000372-wzwpyvll	533	18	G	G	NNP
cord-000372-wzwpyvll	533	19	to	to	TO
cord-000372-wzwpyvll	533	20	translate	translate	VB
cord-000372-wzwpyvll	533	21	different	different	JJ
cord-000372-wzwpyvll	533	22	cellular	cellular	JJ
cord-000372-wzwpyvll	533	23	or	or	CC
cord-000372-wzwpyvll	533	24	viral	viral	JJ
cord-000372-wzwpyvll	533	25	mRNAs	mrna	NNS
cord-000372-wzwpyvll	533	26	.	.	.
cord-000372-wzwpyvll	534	1	In	in	IN
cord-000372-wzwpyvll	534	2	addition	addition	NN
cord-000372-wzwpyvll	534	3	to	to	IN
cord-000372-wzwpyvll	534	4	this	this	DT
cord-000372-wzwpyvll	534	5	,	,	,
cord-000372-wzwpyvll	534	6	in	in	IN
cord-000372-wzwpyvll	534	7	this	this	DT
cord-000372-wzwpyvll	534	8	paper	paper	NN
cord-000372-wzwpyvll	534	9	,	,	,
cord-000372-wzwpyvll	534	10	we	-PRON-	PRP
cord-000372-wzwpyvll	534	11	have	have	VBP
cord-000372-wzwpyvll	534	12	highlighted	highlight	VBN
cord-000372-wzwpyvll	534	13	the	the	DT
cord-000372-wzwpyvll	534	14	role	role	NN
cord-000372-wzwpyvll	534	15	of	of	IN
cord-000372-wzwpyvll	534	16	PV	PV	NNP
cord-000372-wzwpyvll	534	17	2A	2a	CD
cord-000372-wzwpyvll	534	18	pro	pro	JJ
cord-000372-wzwpyvll	534	19	not	not	RB
cord-000372-wzwpyvll	534	20	only	only	RB
cord-000372-wzwpyvll	534	21	in	in	IN
cord-000372-wzwpyvll	534	22	the	the	DT
cord-000372-wzwpyvll	534	23	processing	processing	NN
cord-000372-wzwpyvll	534	24	of	of	IN
cord-000372-wzwpyvll	534	25	the	the	DT
cord-000372-wzwpyvll	534	26	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	534	27	polyprotein	polyprotein	NN
cord-000372-wzwpyvll	534	28	but	but	CC
cord-000372-wzwpyvll	534	29	also	also	RB
cord-000372-wzwpyvll	534	30	in	in	IN
cord-000372-wzwpyvll	534	31	the	the	DT
cord-000372-wzwpyvll	534	32	interaction	interaction	NN
cord-000372-wzwpyvll	534	33	with	with	IN
cord-000372-wzwpyvll	534	34	the	the	DT
cord-000372-wzwpyvll	534	35	host	host	NN
cord-000372-wzwpyvll	534	36	-	-	HYPH
cord-000372-wzwpyvll	534	37	cell	cell	NN
cord-000372-wzwpyvll	534	38	.	.	.
cord-000372-wzwpyvll	535	1	Interestingly	interestingly	RB
cord-000372-wzwpyvll	535	2	,	,	,
cord-000372-wzwpyvll	535	3	a	a	DT
cord-000372-wzwpyvll	535	4	single	single	JJ
cord-000372-wzwpyvll	535	5	viral	viral	JJ
cord-000372-wzwpyvll	535	6	protein	protein	NN
cord-000372-wzwpyvll	535	7	is	be	VBZ
cord-000372-wzwpyvll	535	8	able	able	JJ
cord-000372-wzwpyvll	535	9	to	to	TO
cord-000372-wzwpyvll	535	10	modulate	modulate	VB
cord-000372-wzwpyvll	535	11	many	many	JJ
cord-000372-wzwpyvll	535	12	steps	step	NNS
cord-000372-wzwpyvll	535	13	of	of	IN
cord-000372-wzwpyvll	535	14	gene	gene	NN
cord-000372-wzwpyvll	535	15	expression	expression	NN
cord-000372-wzwpyvll	535	16	in	in	IN
cord-000372-wzwpyvll	535	17	order	order	NN
cord-000372-wzwpyvll	535	18	to	to	TO
cord-000372-wzwpyvll	535	19	generate	generate	VB
cord-000372-wzwpyvll	535	20	an	an	DT
cord-000372-wzwpyvll	535	21	optimal	optimal	JJ
cord-000372-wzwpyvll	535	22	intracellular	intracellular	JJ
cord-000372-wzwpyvll	535	23	environment	environment	NN
cord-000372-wzwpyvll	535	24	for	for	IN
cord-000372-wzwpyvll	535	25	the	the	DT
cord-000372-wzwpyvll	535	26	viral	viral	JJ
cord-000372-wzwpyvll	535	27	biological	biological	JJ
cord-000372-wzwpyvll	535	28	cycle	cycle	NN
cord-000372-wzwpyvll	535	29	.	.	.
cord-000372-wzwpyvll	536	1	In	in	IN
cord-000372-wzwpyvll	536	2	particular	particular	JJ
cord-000372-wzwpyvll	536	3	,	,	,
cord-000372-wzwpyvll	536	4	PV	PV	NNP
cord-000372-wzwpyvll	536	5	2A	2a	NN
cord-000372-wzwpyvll	536	6	pro	pro	NNP
cord-000372-wzwpyvll	536	7	cleaves	cleave	VBZ
cord-000372-wzwpyvll	536	8	cell	cell	NN
cord-000372-wzwpyvll	536	9	proteins	protein	NNS
cord-000372-wzwpyvll	536	10	involved	involve	VBN
cord-000372-wzwpyvll	536	11	in	in	IN
cord-000372-wzwpyvll	536	12	transcription	transcription	NN
cord-000372-wzwpyvll	536	13	,	,	,
cord-000372-wzwpyvll	536	14	pre	pre	JJ
cord-000372-wzwpyvll	536	15	-	-	JJ
cord-000372-wzwpyvll	536	16	mRNA	mrna	JJ
cord-000372-wzwpyvll	536	17	splicing	splicing	NN
cord-000372-wzwpyvll	536	18	,	,	,
cord-000372-wzwpyvll	536	19	nucleus	nucleus	NN
cord-000372-wzwpyvll	536	20	/	/	SYM
cord-000372-wzwpyvll	536	21	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	536	22	transport	transport	NN
cord-000372-wzwpyvll	536	23	and	and	CC
cord-000372-wzwpyvll	536	24	translation	translation	NN
cord-000372-wzwpyvll	536	25	,	,	,
cord-000372-wzwpyvll	536	26	in	in	IN
cord-000372-wzwpyvll	536	27	order	order	NN
cord-000372-wzwpyvll	536	28	to	to	TO
cord-000372-wzwpyvll	536	29	hijack	hijack	VB
cord-000372-wzwpyvll	536	30	those	those	DT
cord-000372-wzwpyvll	536	31	host	host	NN
cord-000372-wzwpyvll	536	32	functions	function	NNS
cord-000372-wzwpyvll	536	33	and	and	CC
cord-000372-wzwpyvll	536	34	to	to	TO
cord-000372-wzwpyvll	536	35	concentrate	concentrate	VB
cord-000372-wzwpyvll	536	36	the	the	DT
cord-000372-wzwpyvll	536	37	cellular	cellular	JJ
cord-000372-wzwpyvll	536	38	resources	resource	NNS
cord-000372-wzwpyvll	536	39	on	on	IN
cord-000372-wzwpyvll	536	40	the	the	DT
cord-000372-wzwpyvll	536	41	production	production	NN
cord-000372-wzwpyvll	536	42	of	of	IN
cord-000372-wzwpyvll	536	43	the	the	DT
cord-000372-wzwpyvll	536	44	viral	viral	JJ
cord-000372-wzwpyvll	536	45	progeny	progeny	NN
cord-000372-wzwpyvll	536	46	.	.	.
cord-000372-wzwpyvll	537	1	For	for	IN
cord-000372-wzwpyvll	537	2	example	example	NN
cord-000372-wzwpyvll	537	3	,	,	,
cord-000372-wzwpyvll	537	4	PV	PV	NNP
cord-000372-wzwpyvll	537	5	2A	2a	NN
cord-000372-wzwpyvll	537	6	pro	pro	NNP
cord-000372-wzwpyvll	537	7	inactivates	inactivate	VBZ
cord-000372-wzwpyvll	537	8	host	host	NN
cord-000372-wzwpyvll	537	9	translational	translational	JJ
cord-000372-wzwpyvll	537	10	machinery	machinery	NN
cord-000372-wzwpyvll	537	11	for	for	IN
cord-000372-wzwpyvll	537	12	capped	cap	VBN
cord-000372-wzwpyvll	537	13	cellular	cellular	NN
cord-000372-wzwpyvll	537	14	mRNAs	mrna	NNS
cord-000372-wzwpyvll	537	15	by	by	IN
cord-000372-wzwpyvll	537	16	cleaving	cleave	VBG
cord-000372-wzwpyvll	537	17	eIF4	eif4	IN
cord-000372-wzwpyvll	537	18	G	G	NNP
cord-000372-wzwpyvll	537	19	,	,	,
cord-000372-wzwpyvll	537	20	whereas	whereas	IN
cord-000372-wzwpyvll	537	21	viral	viral	JJ
cord-000372-wzwpyvll	537	22	protein	protein	NN
cord-000372-wzwpyvll	537	23	synthesis	synthesis	NN
cord-000372-wzwpyvll	537	24	takes	take	VBZ
cord-000372-wzwpyvll	537	25	place	place	NN
cord-000372-wzwpyvll	537	26	under	under	IN
cord-000372-wzwpyvll	537	27	those	those	DT
cord-000372-wzwpyvll	537	28	conditions	condition	NNS
cord-000372-wzwpyvll	537	29	by	by	IN
cord-000372-wzwpyvll	537	30	IRES	IRES	NNP
cord-000372-wzwpyvll	537	31	-	-	HYPH
cord-000372-wzwpyvll	537	32	driven	drive	VBN
cord-000372-wzwpyvll	537	33	translation	translation	NN
cord-000372-wzwpyvll	537	34	[	[	-LRB-
cord-000372-wzwpyvll	537	35	14	14	CD
cord-000372-wzwpyvll	537	36	]	]	-RRB-
cord-000372-wzwpyvll	537	37	.	.	.
cord-000372-wzwpyvll	538	1	Because	because	IN
cord-000372-wzwpyvll	538	2	of	of	IN
cord-000372-wzwpyvll	538	3	the	the	DT
cord-000372-wzwpyvll	538	4	decrease	decrease	NN
cord-000372-wzwpyvll	538	5	of	of	IN
cord-000372-wzwpyvll	538	6	cellular	cellular	JJ
cord-000372-wzwpyvll	538	7	mRNA	mrna	NN
cord-000372-wzwpyvll	538	8	translatability	translatability	NN
cord-000372-wzwpyvll	538	9	in	in	IN
cord-000372-wzwpyvll	538	10	PV	pv	NN
cord-000372-wzwpyvll	538	11	-	-	HYPH
cord-000372-wzwpyvll	538	12	infected	infect	VBN
cord-000372-wzwpyvll	538	13	cells	cell	NNS
cord-000372-wzwpyvll	538	14	,	,	,
cord-000372-wzwpyvll	538	15	host	host	NN
cord-000372-wzwpyvll	538	16	ribosomes	ribosome	NNS
cord-000372-wzwpyvll	538	17	are	be	VBP
cord-000372-wzwpyvll	538	18	available	available	JJ
cord-000372-wzwpyvll	538	19	for	for	IN
cord-000372-wzwpyvll	538	20	viral	viral	JJ
cord-000372-wzwpyvll	538	21	protein	protein	NN
cord-000372-wzwpyvll	538	22	synthesis	synthesis	NN
cord-000372-wzwpyvll	538	23	.	.	.
cord-000372-wzwpyvll	539	1	Probably	probably	RB
cord-000372-wzwpyvll	539	2	,	,	,
cord-000372-wzwpyvll	539	3	the	the	DT
cord-000372-wzwpyvll	539	4	inhibition	inhibition	NN
cord-000372-wzwpyvll	539	5	of	of	IN
cord-000372-wzwpyvll	539	6	host	host	NN
cord-000372-wzwpyvll	539	7	protein	protein	NN
cord-000372-wzwpyvll	539	8	synthesis	synthesis	NN
cord-000372-wzwpyvll	539	9	may	may	MD
cord-000372-wzwpyvll	539	10	prevent	prevent	VB
cord-000372-wzwpyvll	539	11	the	the	DT
cord-000372-wzwpyvll	539	12	production	production	NN
cord-000372-wzwpyvll	539	13	of	of	IN
cord-000372-wzwpyvll	539	14	antiviral	antiviral	JJ
cord-000372-wzwpyvll	539	15	proteins	protein	NNS
cord-000372-wzwpyvll	539	16	.	.	.
cord-000372-wzwpyvll	540	1	Similarly	similarly	RB
cord-000372-wzwpyvll	540	2	,	,	,
cord-000372-wzwpyvll	540	3	the	the	DT
cord-000372-wzwpyvll	540	4	blockade	blockade	NN
cord-000372-wzwpyvll	540	5	of	of	IN
cord-000372-wzwpyvll	540	6	nucleus	nucleus	NN
cord-000372-wzwpyvll	540	7	/	/	SYM
cord-000372-wzwpyvll	540	8	cytoplasm	cytoplasm	JJ
cord-000372-wzwpyvll	540	9	transport	transport	NN
cord-000372-wzwpyvll	540	10	of	of	IN
cord-000372-wzwpyvll	540	11	macromolecules	macromolecule	NNS
cord-000372-wzwpyvll	540	12	might	may	MD
cord-000372-wzwpyvll	540	13	isolate	isolate	VB
cord-000372-wzwpyvll	540	14	nuclear	nuclear	JJ
cord-000372-wzwpyvll	540	15	processes	process	NNS
cord-000372-wzwpyvll	540	16	from	from	IN
cord-000372-wzwpyvll	540	17	cytoplasmic	cytoplasmic	JJ
cord-000372-wzwpyvll	540	18	cellular	cellular	JJ
cord-000372-wzwpyvll	540	19	ones	one	NNS
cord-000372-wzwpyvll	540	20	,	,	,
cord-000372-wzwpyvll	540	21	hampering	hamper	VBG
cord-000372-wzwpyvll	540	22	the	the	DT
cord-000372-wzwpyvll	540	23	arrival	arrival	NN
cord-000372-wzwpyvll	540	24	of	of	IN
cord-000372-wzwpyvll	540	25	specific	specific	JJ
cord-000372-wzwpyvll	540	26	proinflammatory	proinflammatory	JJ
cord-000372-wzwpyvll	540	27	transcription	transcription	NN
cord-000372-wzwpyvll	540	28	factors	factor	NNS
cord-000372-wzwpyvll	540	29	to	to	IN
cord-000372-wzwpyvll	540	30	the	the	DT
cord-000372-wzwpyvll	540	31	nucleus	nucleus	NN
cord-000372-wzwpyvll	540	32	and	and	CC
cord-000372-wzwpyvll	540	33	of	of	IN
cord-000372-wzwpyvll	540	34	mRNAs	mRNAs	NNPS
cord-000372-wzwpyvll	540	35	encoding	encode	VBG
cord-000372-wzwpyvll	540	36	proinflammatory	proinflammatory	JJ
cord-000372-wzwpyvll	540	37	,	,	,
cord-000372-wzwpyvll	540	38	antiviral	antiviral	JJ
cord-000372-wzwpyvll	540	39	or	or	CC
cord-000372-wzwpyvll	540	40	proapoptotic	proapoptotic	JJ
cord-000372-wzwpyvll	540	41	proteins	protein	NNS
cord-000372-wzwpyvll	540	42	to	to	IN
cord-000372-wzwpyvll	540	43	the	the	DT
cord-000372-wzwpyvll	540	44	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	540	45	of	of	IN
cord-000372-wzwpyvll	540	46	infected	infected	JJ
cord-000372-wzwpyvll	540	47	cells	cell	NNS
cord-000372-wzwpyvll	540	48	.	.	.
cord-000372-wzwpyvll	541	1	Finally	finally	RB
cord-000372-wzwpyvll	541	2	,	,	,
cord-000372-wzwpyvll	541	3	transcription	transcription	NN
cord-000372-wzwpyvll	541	4	and	and	CC
cord-000372-wzwpyvll	541	5	pre	pre	JJ
cord-000372-wzwpyvll	541	6	-	-	JJ
cord-000372-wzwpyvll	541	7	mRNA	mrna	JJ
cord-000372-wzwpyvll	541	8	splicing	splicing	NN
cord-000372-wzwpyvll	541	9	could	could	MD
cord-000372-wzwpyvll	541	10	be	be	VB
cord-000372-wzwpyvll	541	11	also	also	RB
cord-000372-wzwpyvll	541	12	modulated	modulate	VBN
cord-000372-wzwpyvll	541	13	by	by	IN
cord-000372-wzwpyvll	541	14	PV	PV	NNP
cord-000372-wzwpyvll	541	15	2A	2a	CD
cord-000372-wzwpyvll	541	16	pro	pro	JJ
cord-000372-wzwpyvll	541	17	and	and	CC
cord-000372-wzwpyvll	541	18	might	may	MD
cord-000372-wzwpyvll	541	19	reduce	reduce	VB
cord-000372-wzwpyvll	541	20	the	the	DT
cord-000372-wzwpyvll	541	21	availability	availability	NN
cord-000372-wzwpyvll	541	22	of	of	IN
cord-000372-wzwpyvll	541	23	mature	mature	NN
cord-000372-wzwpyvll	541	24	mRNAs	mrna	NNS
cord-000372-wzwpyvll	541	25	.	.	.
cord-000372-wzwpyvll	542	1	Nevertheless	nevertheless	RB
cord-000372-wzwpyvll	542	2	,	,	,
cord-000372-wzwpyvll	542	3	very	very	RB
cord-000372-wzwpyvll	542	4	little	little	JJ
cord-000372-wzwpyvll	542	5	is	be	VBZ
cord-000372-wzwpyvll	542	6	known	know	VBN
cord-000372-wzwpyvll	542	7	about	about	IN
cord-000372-wzwpyvll	542	8	the	the	DT
cord-000372-wzwpyvll	542	9	potential	potential	JJ
cord-000372-wzwpyvll	542	10	role	role	NN
cord-000372-wzwpyvll	542	11	of	of	IN
cord-000372-wzwpyvll	542	12	PV	PV	NNP
cord-000372-wzwpyvll	542	13	2A	2a	CD
cord-000372-wzwpyvll	542	14	pro	pro	JJ
cord-000372-wzwpyvll	542	15	in	in	IN
cord-000372-wzwpyvll	542	16	transcription	transcription	NN
cord-000372-wzwpyvll	542	17	and	and	CC
cord-000372-wzwpyvll	542	18	pre	pre	JJ
cord-000372-wzwpyvll	542	19	-	-	JJ
cord-000372-wzwpyvll	542	20	mRNA	mrna	JJ
cord-000372-wzwpyvll	542	21	splicing	splicing	NN
cord-000372-wzwpyvll	542	22	,	,	,
cord-000372-wzwpyvll	542	23	and	and	CC
cord-000372-wzwpyvll	542	24	further	further	JJ
cord-000372-wzwpyvll	542	25	studies	study	NNS
cord-000372-wzwpyvll	542	26	of	of	IN
cord-000372-wzwpyvll	542	27	these	these	DT
cord-000372-wzwpyvll	542	28	steps	step	NNS
cord-000372-wzwpyvll	542	29	of	of	IN
cord-000372-wzwpyvll	542	30	gene	gene	NN
cord-000372-wzwpyvll	542	31	expression	expression	NN
cord-000372-wzwpyvll	542	32	in	in	IN
cord-000372-wzwpyvll	542	33	PV	pv	NN
cord-000372-wzwpyvll	542	34	-	-	HYPH
cord-000372-wzwpyvll	542	35	infected	infect	VBN
cord-000372-wzwpyvll	542	36	and	and	CC
cord-000372-wzwpyvll	542	37	2A	2a	CD
cord-000372-wzwpyvll	542	38	-	-	HYPH
cord-000372-wzwpyvll	542	39	expressing	express	VBG
cord-000372-wzwpyvll	542	40	cells	cell	NNS
cord-000372-wzwpyvll	542	41	should	should	MD
cord-000372-wzwpyvll	542	42	be	be	VB
cord-000372-wzwpyvll	542	43	carried	carry	VBN
cord-000372-wzwpyvll	542	44	out	out	RP
cord-000372-wzwpyvll	542	45	.	.	.
cord-000372-wzwpyvll	543	1	Making	make	VBG
cord-000372-wzwpyvll	543	2	use	use	NN
cord-000372-wzwpyvll	543	3	of	of	IN
cord-000372-wzwpyvll	543	4	the	the	DT
cord-000372-wzwpyvll	543	5	"	"	``
cord-000372-wzwpyvll	543	6	omics	omic	NNS
cord-000372-wzwpyvll	543	7	"	"	''
cord-000372-wzwpyvll	543	8	technologies	technology	NNS
cord-000372-wzwpyvll	543	9	it	-PRON-	PRP
cord-000372-wzwpyvll	543	10	would	would	MD
cord-000372-wzwpyvll	543	11	be	be	VB
cord-000372-wzwpyvll	543	12	possible	possible	JJ
cord-000372-wzwpyvll	543	13	to	to	TO
cord-000372-wzwpyvll	543	14	identify	identify	VB
cord-000372-wzwpyvll	543	15	changes	change	NNS
cord-000372-wzwpyvll	543	16	in	in	IN
cord-000372-wzwpyvll	543	17	the	the	DT
cord-000372-wzwpyvll	543	18	host	host	NN
cord-000372-wzwpyvll	543	19	transcriptome	transcriptome	NN
cord-000372-wzwpyvll	543	20	in	in	IN
cord-000372-wzwpyvll	543	21	those	those	DT
cord-000372-wzwpyvll	543	22	cells	cell	NNS
cord-000372-wzwpyvll	543	23	,	,	,
cord-000372-wzwpyvll	543	24	allowing	allow	VBG
cord-000372-wzwpyvll	543	25	us	-PRON-	PRP
cord-000372-wzwpyvll	543	26	to	to	TO
cord-000372-wzwpyvll	543	27	understand	understand	VB
cord-000372-wzwpyvll	543	28	the	the	DT
cord-000372-wzwpyvll	543	29	readjustment	readjustment	NN
cord-000372-wzwpyvll	543	30	of	of	IN
cord-000372-wzwpyvll	543	31	host	host	NN
cord-000372-wzwpyvll	543	32	gene	gene	NN
cord-000372-wzwpyvll	543	33	expression	expression	NN
cord-000372-wzwpyvll	543	34	to	to	IN
cord-000372-wzwpyvll	543	35	viral	viral	JJ
cord-000372-wzwpyvll	543	36	infection	infection	NN
cord-000372-wzwpyvll	543	37	and	and	CC
cord-000372-wzwpyvll	543	38	to	to	IN
cord-000372-wzwpyvll	543	39	the	the	DT
cord-000372-wzwpyvll	543	40	cytotoxic	cytotoxic	JJ
cord-000372-wzwpyvll	543	41	effect	effect	NN
cord-000372-wzwpyvll	543	42	of	of	IN
cord-000372-wzwpyvll	543	43	PV	PV	NNP
cord-000372-wzwpyvll	543	44	2A	2a	CD
cord-000372-wzwpyvll	544	1	pro	pro	JJ
cord-000372-wzwpyvll	544	2	.	.	.
cord-000372-wzwpyvll	545	1	Gene	gene	NN
cord-000372-wzwpyvll	545	2	ontology	ontology	NN
cord-000372-wzwpyvll	545	3	tools	tool	NNS
cord-000372-wzwpyvll	545	4	can	can	MD
cord-000372-wzwpyvll	545	5	be	be	VB
cord-000372-wzwpyvll	545	6	used	use	VBN
cord-000372-wzwpyvll	545	7	to	to	TO
cord-000372-wzwpyvll	545	8	cluster	cluster	VB
cord-000372-wzwpyvll	545	9	the	the	DT
cord-000372-wzwpyvll	545	10	pathways	pathway	NNS
cord-000372-wzwpyvll	545	11	(	(	-LRB-
cord-000372-wzwpyvll	545	12	KEGG	KEGG	NNP
cord-000372-wzwpyvll	545	13	)	)	-RRB-
cord-000372-wzwpyvll	545	14	,	,	,
cord-000372-wzwpyvll	545	15	molecular	molecular	JJ
cord-000372-wzwpyvll	545	16	activities	activity	NNS
cord-000372-wzwpyvll	545	17	and	and	CC
cord-000372-wzwpyvll	545	18	biological	biological	JJ
cord-000372-wzwpyvll	545	19	functions	function	NNS
cord-000372-wzwpyvll	545	20	of	of	IN
cord-000372-wzwpyvll	545	21	the	the	DT
cord-000372-wzwpyvll	545	22	genes	gene	NNS
cord-000372-wzwpyvll	545	23	which	which	WDT
cord-000372-wzwpyvll	545	24	are	be	VBP
cord-000372-wzwpyvll	545	25	transcriptionally	transcriptionally	RB
cord-000372-wzwpyvll	545	26	up	up	RB
cord-000372-wzwpyvll	545	27	-	-	:
cord-000372-wzwpyvll	545	28	or	or	CC
cord-000372-wzwpyvll	545	29	downregulated	downregulate	VBN
cord-000372-wzwpyvll	545	30	or	or	CC
cord-000372-wzwpyvll	545	31	not	not	RB
cord-000372-wzwpyvll	545	32	affected	affect	VBN
cord-000372-wzwpyvll	545	33	after	after	IN
cord-000372-wzwpyvll	545	34	these	these	DT
cord-000372-wzwpyvll	545	35	unfavourable	unfavourable	JJ
cord-000372-wzwpyvll	545	36	stimuli	stimulus	NNS
cord-000372-wzwpyvll	545	37	.	.	.
cord-000372-wzwpyvll	546	1	In	in	IN
cord-000372-wzwpyvll	546	2	silico	silico	NN
cord-000372-wzwpyvll	546	3	analysis	analysis	NN
cord-000372-wzwpyvll	546	4	could	could	MD
cord-000372-wzwpyvll	546	5	be	be	VB
cord-000372-wzwpyvll	546	6	carried	carry	VBN
cord-000372-wzwpyvll	546	7	out	out	RP
cord-000372-wzwpyvll	546	8	in	in	IN
cord-000372-wzwpyvll	546	9	order	order	NN
cord-000372-wzwpyvll	546	10	to	to	TO
cord-000372-wzwpyvll	546	11	identify	identify	VB
cord-000372-wzwpyvll	546	12	whether	whether	IN
cord-000372-wzwpyvll	546	13	these	these	DT
cord-000372-wzwpyvll	546	14	gene	gene	NN
cord-000372-wzwpyvll	546	15	clusters	cluster	NNS
cord-000372-wzwpyvll	546	16	belong	belong	VBP
cord-000372-wzwpyvll	546	17	to	to	IN
cord-000372-wzwpyvll	546	18	particular	particular	JJ
cord-000372-wzwpyvll	546	19	networks	network	NNS
cord-000372-wzwpyvll	546	20	controlled	control	VBN
cord-000372-wzwpyvll	546	21	by	by	IN
cord-000372-wzwpyvll	546	22	specific	specific	JJ
cord-000372-wzwpyvll	546	23	transcription	transcription	NN
cord-000372-wzwpyvll	546	24	factors	factor	NNS
cord-000372-wzwpyvll	546	25	.	.	.
cord-000372-wzwpyvll	547	1	This	this	DT
cord-000372-wzwpyvll	547	2	approach	approach	NN
cord-000372-wzwpyvll	547	3	will	will	MD
cord-000372-wzwpyvll	547	4	give	give	VB
cord-000372-wzwpyvll	547	5	us	-PRON-	PRP
cord-000372-wzwpyvll	547	6	additional	additional	JJ
cord-000372-wzwpyvll	547	7	information	information	NN
cord-000372-wzwpyvll	547	8	about	about	IN
cord-000372-wzwpyvll	547	9	potential	potential	JJ
cord-000372-wzwpyvll	547	10	host	host	NN
cord-000372-wzwpyvll	547	11	targets	target	NNS
cord-000372-wzwpyvll	547	12	for	for	IN
cord-000372-wzwpyvll	547	13	PV	PV	NNP
cord-000372-wzwpyvll	547	14	2A	2a	CD
cord-000372-wzwpyvll	547	15	pro	pro	JJ
cord-000372-wzwpyvll	547	16	.	.	.
cord-000372-wzwpyvll	548	1	Complementarily	Complementarily	NNP
cord-000372-wzwpyvll	548	2	,	,	,
cord-000372-wzwpyvll	548	3	deep	deep	JJ
cord-000372-wzwpyvll	548	4	sequence	sequence	NN
cord-000372-wzwpyvll	548	5	(	(	-LRB-
cord-000372-wzwpyvll	548	6	RNAseq	RNAseq	NNP
cord-000372-wzwpyvll	548	7	)	)	-RRB-
cord-000372-wzwpyvll	548	8	,	,	,
cord-000372-wzwpyvll	548	9	specific	specific	JJ
cord-000372-wzwpyvll	548	10	microarrays	microarray	NNS
cord-000372-wzwpyvll	548	11	types	type	NNS
cord-000372-wzwpyvll	548	12	and	and	CC
cord-000372-wzwpyvll	548	13	conventional	conventional	JJ
cord-000372-wzwpyvll	548	14	RT	RT	NNP
cord-000372-wzwpyvll	548	15	-	-	HYPH
cord-000372-wzwpyvll	548	16	PCR	PCR	NNP
cord-000372-wzwpyvll	548	17	could	could	MD
cord-000372-wzwpyvll	548	18	be	be	VB
cord-000372-wzwpyvll	548	19	used	use	VBN
cord-000372-wzwpyvll	548	20	to	to	TO
cord-000372-wzwpyvll	548	21	screen	screen	VB
cord-000372-wzwpyvll	548	22	for	for	IN
cord-000372-wzwpyvll	548	23	nonspliced	nonspliced	JJ
cord-000372-wzwpyvll	548	24	or	or	CC
cord-000372-wzwpyvll	548	25	abnormal	abnormal	JJ
cord-000372-wzwpyvll	548	26	spliced	splice	VBN
cord-000372-wzwpyvll	548	27	mRNA	mrna	NN
cord-000372-wzwpyvll	548	28	variants	variant	NNS
cord-000372-wzwpyvll	548	29	in	in	IN
cord-000372-wzwpyvll	548	30	PV	pv	NN
cord-000372-wzwpyvll	548	31	-	-	HYPH
cord-000372-wzwpyvll	548	32	infected	infect	VBN
cord-000372-wzwpyvll	548	33	and	and	CC
cord-000372-wzwpyvll	548	34	2A	2a	CD
cord-000372-wzwpyvll	548	35	pro	pro	JJ
cord-000372-wzwpyvll	548	36	-expressing	-expressing	NN
cord-000372-wzwpyvll	548	37	cells	cell	NNS
cord-000372-wzwpyvll	548	38	.	.	.
cord-000372-wzwpyvll	549	1	Finally	finally	RB
cord-000372-wzwpyvll	549	2	,	,	,
cord-000372-wzwpyvll	549	3	microarrays	microarray	NNS
cord-000372-wzwpyvll	549	4	can	can	MD
cord-000372-wzwpyvll	549	5	be	be	VB
cord-000372-wzwpyvll	549	6	employed	employ	VBN
cord-000372-wzwpyvll	549	7	to	to	TO
cord-000372-wzwpyvll	549	8	identify	identify	VB
cord-000372-wzwpyvll	549	9	the	the	DT
cord-000372-wzwpyvll	549	10	cytoplasmic	cytoplasmic	JJ
cord-000372-wzwpyvll	549	11	and	and	CC
cord-000372-wzwpyvll	549	12	nuclear	nuclear	JJ
cord-000372-wzwpyvll	549	13	transcriptome	transcriptome	NN
cord-000372-wzwpyvll	549	14	in	in	IN
cord-000372-wzwpyvll	549	15	those	those	DT
cord-000372-wzwpyvll	549	16	cells	cell	NNS
cord-000372-wzwpyvll	549	17	to	to	TO
cord-000372-wzwpyvll	549	18	determine	determine	VB
cord-000372-wzwpyvll	549	19	whether	whether	IN
cord-000372-wzwpyvll	549	20	mRNA	mRNA	NNP
cord-000372-wzwpyvll	549	21	nuclear	nuclear	JJ
cord-000372-wzwpyvll	549	22	export	export	NN
cord-000372-wzwpyvll	549	23	inhibition	inhibition	NN
cord-000372-wzwpyvll	549	24	induced	induce	VBN
cord-000372-wzwpyvll	549	25	by	by	IN
cord-000372-wzwpyvll	549	26	PV	PV	NNP
cord-000372-wzwpyvll	549	27	2A	2a	CD
cord-000372-wzwpyvll	549	28	pro	pro	JJ
cord-000372-wzwpyvll	549	29	impacts	impact	NNS
cord-000372-wzwpyvll	549	30	on	on	IN
cord-000372-wzwpyvll	549	31	the	the	DT
cord-000372-wzwpyvll	549	32	distribution	distribution	NN
cord-000372-wzwpyvll	549	33	of	of	IN
cord-000372-wzwpyvll	549	34	the	the	DT
cord-000372-wzwpyvll	549	35	entire	entire	JJ
cord-000372-wzwpyvll	549	36	host	host	NN
cord-000372-wzwpyvll	549	37	mRNA	mrna	NN
cord-000372-wzwpyvll	549	38	bulk	bulk	NN
cord-000372-wzwpyvll	549	39	or	or	CC
cord-000372-wzwpyvll	549	40	in	in	IN
cord-000372-wzwpyvll	549	41	specific	specific	JJ
cord-000372-wzwpyvll	549	42	mRNA	mRNA	NNP
cord-000372-wzwpyvll	549	43	pools	pool	NNS
cord-000372-wzwpyvll	549	44	.	.	.
cord-000372-wzwpyvll	550	1	Taken	take	VBN
cord-000372-wzwpyvll	550	2	together	together	RB
cord-000372-wzwpyvll	550	3	,	,	,
cord-000372-wzwpyvll	550	4	all	all	PDT
cord-000372-wzwpyvll	550	5	this	this	DT
cord-000372-wzwpyvll	550	6	information	information	NN
cord-000372-wzwpyvll	550	7	may	may	MD
cord-000372-wzwpyvll	550	8	provide	provide	VB
cord-000372-wzwpyvll	550	9	us	-PRON-	PRP
cord-000372-wzwpyvll	550	10	with	with	IN
cord-000372-wzwpyvll	550	11	a	a	DT
cord-000372-wzwpyvll	550	12	general	general	JJ
cord-000372-wzwpyvll	550	13	and	and	CC
cord-000372-wzwpyvll	550	14	deep	deep	JJ
cord-000372-wzwpyvll	550	15	vision	vision	NN
cord-000372-wzwpyvll	550	16	of	of	IN
cord-000372-wzwpyvll	550	17	the	the	DT
cord-000372-wzwpyvll	550	18	modification	modification	NN
cord-000372-wzwpyvll	550	19	induced	induce	VBN
cord-000372-wzwpyvll	550	20	by	by	IN
cord-000372-wzwpyvll	550	21	PV	PV	NNP
cord-000372-wzwpyvll	550	22	2A	2a	CD
cord-000372-wzwpyvll	550	23	pro	pro	JJ
cord-000372-wzwpyvll	550	24	on	on	IN
cord-000372-wzwpyvll	550	25	the	the	DT
cord-000372-wzwpyvll	550	26	different	different	JJ
cord-000372-wzwpyvll	550	27	steps	step	NNS
cord-000372-wzwpyvll	550	28	of	of	IN
cord-000372-wzwpyvll	550	29	mRNA	mRNA	NNP
cord-000372-wzwpyvll	550	30	metabolism	metabolism	NN
cord-000372-wzwpyvll	550	31	.	.	.
cord-000372-wzwpyvll	551	1	Additionally	additionally	RB
cord-000372-wzwpyvll	551	2	,	,	,
cord-000372-wzwpyvll	551	3	the	the	DT
cord-000372-wzwpyvll	551	4	physiological	physiological	JJ
cord-000372-wzwpyvll	551	5	role	role	NN
cord-000372-wzwpyvll	551	6	of	of	IN
cord-000372-wzwpyvll	551	7	Nups	Nups	NNP
cord-000372-wzwpyvll	551	8	and	and	CC
cord-000372-wzwpyvll	551	9	Gemin-3	Gemin-3	NNP
cord-000372-wzwpyvll	551	10	cleavage	cleavage	NN
cord-000372-wzwpyvll	551	11	might	may	MD
cord-000372-wzwpyvll	551	12	be	be	VB
cord-000372-wzwpyvll	551	13	studied	study	VBN
cord-000372-wzwpyvll	551	14	using	use	VBG
cord-000372-wzwpyvll	551	15	different	different	JJ
cord-000372-wzwpyvll	551	16	models	model	NNS
cord-000372-wzwpyvll	551	17	.	.	.
cord-000372-wzwpyvll	552	1	One	one	CD
cord-000372-wzwpyvll	552	2	possible	possible	JJ
cord-000372-wzwpyvll	552	3	and	and	CC
cord-000372-wzwpyvll	552	4	interesting	interesting	JJ
cord-000372-wzwpyvll	552	5	approach	approach	NN
cord-000372-wzwpyvll	552	6	is	be	VBZ
cord-000372-wzwpyvll	552	7	to	to	TO
cord-000372-wzwpyvll	552	8	engineer	engineer	VB
cord-000372-wzwpyvll	552	9	stable	stable	JJ
cord-000372-wzwpyvll	552	10	cell	cell	NN
cord-000372-wzwpyvll	552	11	lines	line	NNS
cord-000372-wzwpyvll	552	12	expressing	express	VBG
cord-000372-wzwpyvll	552	13	noncleavable	noncleavable	JJ
cord-000372-wzwpyvll	552	14	versions	version	NNS
cord-000372-wzwpyvll	552	15	of	of	IN
cord-000372-wzwpyvll	552	16	Nup98	Nup98	NNP
cord-000372-wzwpyvll	552	17	,	,	,
cord-000372-wzwpyvll	552	18	Nup62	Nup62	NNP
cord-000372-wzwpyvll	552	19	,	,	,
cord-000372-wzwpyvll	552	20	Nup153	Nup153	.
cord-000372-wzwpyvll	553	1	and/or	and/or	CC
cord-000372-wzwpyvll	554	1	Gemin-3	Gemin-3	NNP
cord-000372-wzwpyvll	555	1	and	and	CC
cord-000372-wzwpyvll	555	2	then	then	RB
cord-000372-wzwpyvll	555	3	to	to	TO
cord-000372-wzwpyvll	555	4	analyze	analyze	VB
cord-000372-wzwpyvll	555	5	the	the	DT
cord-000372-wzwpyvll	555	6	fitness	fitness	NN
cord-000372-wzwpyvll	555	7	of	of	IN
cord-000372-wzwpyvll	555	8	PV	PV	NNP
cord-000372-wzwpyvll	555	9	in	in	IN
cord-000372-wzwpyvll	555	10	the	the	DT
cord-000372-wzwpyvll	555	11	different	different	JJ
cord-000372-wzwpyvll	555	12	cell	cell	NN
cord-000372-wzwpyvll	555	13	types	type	NNS
cord-000372-wzwpyvll	555	14	,	,	,
cord-000372-wzwpyvll	555	15	especially	especially	RB
cord-000372-wzwpyvll	555	16	in	in	IN
cord-000372-wzwpyvll	555	17	presence	presence	NN
cord-000372-wzwpyvll	555	18	of	of	IN
cord-000372-wzwpyvll	555	19	extracellular	extracellular	JJ
cord-000372-wzwpyvll	555	20	antiviral	antiviral	JJ
cord-000372-wzwpyvll	555	21	stimuli	stimulus	NNS
cord-000372-wzwpyvll	555	22	such	such	JJ
cord-000372-wzwpyvll	555	23	as	as	IN
cord-000372-wzwpyvll	555	24	IFNs	ifn	NNS
cord-000372-wzwpyvll	555	25	or	or	CC
cord-000372-wzwpyvll	555	26	interleukins	interleukin	NNS
cord-000372-wzwpyvll	555	27	,	,	,
cord-000372-wzwpyvll	555	28	which	which	WDT
cord-000372-wzwpyvll	555	29	will	will	MD
cord-000372-wzwpyvll	555	30	activate	activate	VB
cord-000372-wzwpyvll	555	31	different	different	JJ
cord-000372-wzwpyvll	555	32	epigenetic	epigenetic	JJ
cord-000372-wzwpyvll	555	33	programs	program	NNS
cord-000372-wzwpyvll	555	34	.	.	.
cord-000372-wzwpyvll	556	1	These	these	DT
cord-000372-wzwpyvll	556	2	studies	study	NNS
cord-000372-wzwpyvll	556	3	will	will	MD
cord-000372-wzwpyvll	556	4	provide	provide	VB
cord-000372-wzwpyvll	556	5	essential	essential	JJ
cord-000372-wzwpyvll	556	6	information	information	NN
cord-000372-wzwpyvll	556	7	to	to	TO
cord-000372-wzwpyvll	556	8	help	help	VB
cord-000372-wzwpyvll	556	9	us	-PRON-	PRP
cord-000372-wzwpyvll	556	10	understand	understand	VB
cord-000372-wzwpyvll	556	11	the	the	DT
cord-000372-wzwpyvll	556	12	specific	specific	JJ
cord-000372-wzwpyvll	556	13	role	role	NN
cord-000372-wzwpyvll	556	14	that	that	IN
cord-000372-wzwpyvll	556	15	those	those	DT
cord-000372-wzwpyvll	556	16	host	host	NN
cord-000372-wzwpyvll	556	17	factors	factor	NNS
cord-000372-wzwpyvll	556	18	play	play	VBP
cord-000372-wzwpyvll	556	19	in	in	IN
cord-000372-wzwpyvll	556	20	PV	pv	NN
cord-000372-wzwpyvll	556	21	infection	infection	NN
cord-000372-wzwpyvll	556	22	.	.	.
cord-000372-wzwpyvll	557	1	The	the	DT
cord-000372-wzwpyvll	557	2	total	total	JJ
cord-000372-wzwpyvll	557	3	number	number	NN
cord-000372-wzwpyvll	557	4	of	of	IN
cord-000372-wzwpyvll	557	5	cellular	cellular	JJ
cord-000372-wzwpyvll	557	6	proteins	protein	NNS
cord-000372-wzwpyvll	557	7	targeted	target	VBN
cord-000372-wzwpyvll	557	8	by	by	IN
cord-000372-wzwpyvll	557	9	PV	PV	NNP
cord-000372-wzwpyvll	557	10	2A	2a	CD
cord-000372-wzwpyvll	557	11	pro	pro	NNP
cord-000372-wzwpyvll	557	12	(	(	-LRB-
cord-000372-wzwpyvll	557	13	degradome	degradome	NNP
cord-000372-wzwpyvll	557	14	)	)	-RRB-
cord-000372-wzwpyvll	557	15	remains	remain	VBZ
cord-000372-wzwpyvll	557	16	unknown	unknown	JJ
cord-000372-wzwpyvll	557	17	,	,	,
cord-000372-wzwpyvll	557	18	but	but	CC
cord-000372-wzwpyvll	557	19	it	-PRON-	PRP
cord-000372-wzwpyvll	557	20	can	can	MD
cord-000372-wzwpyvll	557	21	be	be	VB
cord-000372-wzwpyvll	557	22	anticipated	anticipate	VBN
cord-000372-wzwpyvll	557	23	that	that	IN
cord-000372-wzwpyvll	557	24	with	with	IN
cord-000372-wzwpyvll	557	25	the	the	DT
cord-000372-wzwpyvll	557	26	expanding	expand	VBG
cord-000372-wzwpyvll	557	27	use	use	NN
cord-000372-wzwpyvll	557	28	of	of	IN
cord-000372-wzwpyvll	557	29	proteomic	proteomic	JJ
cord-000372-wzwpyvll	557	30	methodologies	methodology	NNS
cord-000372-wzwpyvll	557	31	,	,	,
cord-000372-wzwpyvll	557	32	this	this	DT
cord-000372-wzwpyvll	557	33	analysis	analysis	NN
cord-000372-wzwpyvll	557	34	will	will	MD
cord-000372-wzwpyvll	557	35	be	be	VB
cord-000372-wzwpyvll	557	36	known	know	VBN
cord-000372-wzwpyvll	557	37	soon	soon	RB
cord-000372-wzwpyvll	557	38	not	not	RB
cord-000372-wzwpyvll	557	39	only	only	RB
cord-000372-wzwpyvll	557	40	for	for	IN
cord-000372-wzwpyvll	557	41	PV	PV	NNP
cord-000372-wzwpyvll	557	42	2A	2a	CD
cord-000372-wzwpyvll	557	43	pro	pro	JJ
cord-000372-wzwpyvll	557	44	,	,	,
cord-000372-wzwpyvll	557	45	but	but	CC
cord-000372-wzwpyvll	557	46	also	also	RB
cord-000372-wzwpyvll	557	47	for	for	IN
cord-000372-wzwpyvll	557	48	other	other	JJ
cord-000372-wzwpyvll	557	49	viral	viral	JJ
cord-000372-wzwpyvll	557	50	proteases	protease	NNS
cord-000372-wzwpyvll	557	51	of	of	IN
cord-000372-wzwpyvll	557	52	interest	interest	NN
cord-000372-wzwpyvll	557	53	.	.	.
cord-000372-wzwpyvll	558	1	Furthermore	furthermore	RB
cord-000372-wzwpyvll	558	2	,	,	,
cord-000372-wzwpyvll	558	3	the	the	DT
cord-000372-wzwpyvll	558	4	analysis	analysis	NN
cord-000372-wzwpyvll	558	5	of	of	IN
cord-000372-wzwpyvll	558	6	the	the	DT
cord-000372-wzwpyvll	558	7	PV	PV	NNP
cord-000372-wzwpyvll	558	8	2A	2a	NN
cord-000372-wzwpyvll	558	9	pro	pro	JJ
cord-000372-wzwpyvll	558	10	-induced	-induced	JJ
cord-000372-wzwpyvll	558	11	degradome	degradome	NN
cord-000372-wzwpyvll	558	12	in	in	IN
cord-000372-wzwpyvll	558	13	human	human	JJ
cord-000372-wzwpyvll	558	14	cells	cell	NNS
cord-000372-wzwpyvll	558	15	will	will	MD
cord-000372-wzwpyvll	558	16	be	be	VB
cord-000372-wzwpyvll	558	17	of	of	IN
cord-000372-wzwpyvll	558	18	general	general	JJ
cord-000372-wzwpyvll	558	19	interest	interest	NN
cord-000372-wzwpyvll	558	20	for	for	IN
cord-000372-wzwpyvll	558	21	many	many	JJ
cord-000372-wzwpyvll	558	22	researchers	researcher	NNS
cord-000372-wzwpyvll	558	23	,	,	,
cord-000372-wzwpyvll	558	24	including	include	VBG
cord-000372-wzwpyvll	558	25	virologists	virologist	NNS
cord-000372-wzwpyvll	558	26	and	and	CC
cord-000372-wzwpyvll	558	27	cellular	cellular	JJ
cord-000372-wzwpyvll	558	28	biologists	biologist	NNS
cord-000372-wzwpyvll	558	29	.	.	.
cord-000372-wzwpyvll	559	1	This	this	DT
cord-000372-wzwpyvll	559	2	goal	goal	NN
cord-000372-wzwpyvll	559	3	could	could	MD
cord-000372-wzwpyvll	559	4	be	be	VB
cord-000372-wzwpyvll	559	5	achieved	achieve	VBN
cord-000372-wzwpyvll	559	6	combining	combine	VBG
cord-000372-wzwpyvll	559	7	in	in	IN
cord-000372-wzwpyvll	559	8	silico	silico	NN
cord-000372-wzwpyvll	559	9	prediction	prediction	NN
cord-000372-wzwpyvll	559	10	of	of	IN
cord-000372-wzwpyvll	559	11	2A	2a	CD
cord-000372-wzwpyvll	559	12	pro	pro	JJ
cord-000372-wzwpyvll	559	13	cleavage	cleavage	NN
cord-000372-wzwpyvll	559	14	sites	site	NNS
cord-000372-wzwpyvll	559	15	and	and	CC
cord-000372-wzwpyvll	559	16	experimental	experimental	JJ
cord-000372-wzwpyvll	559	17	tools	tool	NNS
cord-000372-wzwpyvll	559	18	such	such	JJ
cord-000372-wzwpyvll	559	19	as	as	IN
cord-000372-wzwpyvll	559	20	proteomics	proteomic	NNS
cord-000372-wzwpyvll	559	21	.	.	.
cord-000372-wzwpyvll	560	1	In	in	IN
cord-000372-wzwpyvll	560	2	the	the	DT
cord-000372-wzwpyvll	560	3	first	first	JJ
cord-000372-wzwpyvll	560	4	case	case	NN
cord-000372-wzwpyvll	560	5	,	,	,
cord-000372-wzwpyvll	560	6	Blom	Blom	NNP
cord-000372-wzwpyvll	560	7	and	and	CC
cord-000372-wzwpyvll	560	8	collaborators	collaborator	NNS
cord-000372-wzwpyvll	560	9	developed	develop	VBD
cord-000372-wzwpyvll	560	10	a	a	DT
cord-000372-wzwpyvll	560	11	bioinformatics	bioinformatics	NN
cord-000372-wzwpyvll	560	12	tool	tool	NN
cord-000372-wzwpyvll	560	13	using	use	VBG
cord-000372-wzwpyvll	560	14	neural	neural	JJ
cord-000372-wzwpyvll	560	15	network	network	NN
cord-000372-wzwpyvll	560	16	algorithms	algorithm	NNS
cord-000372-wzwpyvll	560	17	to	to	TO
cord-000372-wzwpyvll	560	18	predict	predict	VB
cord-000372-wzwpyvll	560	19	cellular	cellular	JJ
cord-000372-wzwpyvll	560	20	targets	target	NNS
cord-000372-wzwpyvll	560	21	for	for	IN
cord-000372-wzwpyvll	560	22	picornavirus	picornavirus	NN
cord-000372-wzwpyvll	560	23	proteases	protease	NNS
cord-000372-wzwpyvll	560	24	[	[	-LRB-
cord-000372-wzwpyvll	560	25	219	219	CD
cord-000372-wzwpyvll	560	26	]	]	-RRB-
cord-000372-wzwpyvll	560	27	.	.	.
cord-000372-wzwpyvll	561	1	This	this	DT
cord-000372-wzwpyvll	561	2	approach	approach	NN
cord-000372-wzwpyvll	561	3	has	have	VBZ
cord-000372-wzwpyvll	561	4	been	be	VBN
cord-000372-wzwpyvll	561	5	successfully	successfully	RB
cord-000372-wzwpyvll	561	6	used	use	VBN
cord-000372-wzwpyvll	561	7	to	to	TO
cord-000372-wzwpyvll	561	8	predict	predict	VB
cord-000372-wzwpyvll	561	9	the	the	DT
cord-000372-wzwpyvll	561	10	cleavage	cleavage	NN
cord-000372-wzwpyvll	561	11	of	of	IN
cord-000372-wzwpyvll	561	12	dystrophin	dystrophin	NN
cord-000372-wzwpyvll	561	13	by	by	IN
cord-000372-wzwpyvll	561	14	coxsackievirus	coxsackievirus	NNP
cord-000372-wzwpyvll	561	15	2A	2A	NNP
cord-000372-wzwpyvll	561	16	pro	pro	NNP
cord-000372-wzwpyvll	561	17	[	[	-LRB-
cord-000372-wzwpyvll	561	18	220	220	CD
cord-000372-wzwpyvll	561	19	]	]	-RRB-
cord-000372-wzwpyvll	561	20	although	although	IN
cord-000372-wzwpyvll	561	21	most	most	JJS
cord-000372-wzwpyvll	561	22	of	of	IN
cord-000372-wzwpyvll	561	23	the	the	DT
cord-000372-wzwpyvll	561	24	predicted	predict	VBN
cord-000372-wzwpyvll	561	25	human	human	JJ
cord-000372-wzwpyvll	561	26	targets	target	NNS
cord-000372-wzwpyvll	561	27	for	for	IN
cord-000372-wzwpyvll	561	28	rhinovirus	rhinovirus	NN
cord-000372-wzwpyvll	561	29	and	and	CC
cord-000372-wzwpyvll	561	30	enterovirus	enterovirus	NN
cord-000372-wzwpyvll	561	31	2A	2a	CD
cord-000372-wzwpyvll	561	32	pro	pro	NNP
cord-000372-wzwpyvll	561	33	have	have	VBP
cord-000372-wzwpyvll	561	34	not	not	RB
cord-000372-wzwpyvll	561	35	been	be	VBN
cord-000372-wzwpyvll	561	36	proved	prove	VBN
cord-000372-wzwpyvll	561	37	yet	yet	RB
cord-000372-wzwpyvll	561	38	.	.	.
cord-000372-wzwpyvll	562	1	In	in	IN
cord-000372-wzwpyvll	562	2	addition	addition	NN
cord-000372-wzwpyvll	562	3	,	,	,
cord-000372-wzwpyvll	562	4	the	the	DT
cord-000372-wzwpyvll	562	5	algorithm	algorithm	NN
cord-000372-wzwpyvll	562	6	did	do	VBD
cord-000372-wzwpyvll	562	7	not	not	RB
cord-000372-wzwpyvll	562	8	predict	predict	VB
cord-000372-wzwpyvll	562	9	the	the	DT
cord-000372-wzwpyvll	562	10	cleavage	cleavage	NN
cord-000372-wzwpyvll	562	11	of	of	IN
cord-000372-wzwpyvll	562	12	cellular	cellular	JJ
cord-000372-wzwpyvll	562	13	targets	target	NNS
cord-000372-wzwpyvll	562	14	that	that	WDT
cord-000372-wzwpyvll	562	15	have	have	VBP
cord-000372-wzwpyvll	562	16	been	be	VBN
cord-000372-wzwpyvll	562	17	later	later	RB
cord-000372-wzwpyvll	562	18	demonstrated	demonstrate	VBN
cord-000372-wzwpyvll	562	19	to	to	TO
cord-000372-wzwpyvll	562	20	be	be	VB
cord-000372-wzwpyvll	562	21	proteolyzed	proteolyze	VBN
cord-000372-wzwpyvll	562	22	by	by	IN
cord-000372-wzwpyvll	562	23	picornaviral	picornaviral	NNP
cord-000372-wzwpyvll	562	24	2A	2A	NNP
cord-000372-wzwpyvll	562	25	pro	pro	NNP
cord-000372-wzwpyvll	562	26	such	such	JJ
cord-000372-wzwpyvll	562	27	as	as	IN
cord-000372-wzwpyvll	562	28	Nup98	Nup98	NNP
cord-000372-wzwpyvll	562	29	and	and	CC
cord-000372-wzwpyvll	562	30	cytokeratin	cytokeratin	NNP
cord-000372-wzwpyvll	562	31	8	8	CD
cord-000372-wzwpyvll	562	32	[	[	-LRB-
cord-000372-wzwpyvll	562	33	16	16	CD
cord-000372-wzwpyvll	562	34	,	,	,
cord-000372-wzwpyvll	562	35	17	17	CD
cord-000372-wzwpyvll	562	36	,	,	,
cord-000372-wzwpyvll	562	37	221	221	CD
cord-000372-wzwpyvll	562	38	]	]	-RRB-
cord-000372-wzwpyvll	562	39	.	.	.
cord-000372-wzwpyvll	563	1	Thus	thus	RB
cord-000372-wzwpyvll	563	2	,	,	,
cord-000372-wzwpyvll	563	3	it	-PRON-	PRP
cord-000372-wzwpyvll	563	4	would	would	MD
cord-000372-wzwpyvll	563	5	be	be	VB
cord-000372-wzwpyvll	563	6	necessary	necessary	JJ
cord-000372-wzwpyvll	563	7	to	to	TO
cord-000372-wzwpyvll	563	8	develop	develop	VB
cord-000372-wzwpyvll	563	9	an	an	DT
cord-000372-wzwpyvll	563	10	improved	improved	JJ
cord-000372-wzwpyvll	563	11	algorithm	algorithm	NN
cord-000372-wzwpyvll	563	12	able	able	JJ
cord-000372-wzwpyvll	563	13	to	to	TO
cord-000372-wzwpyvll	563	14	find	find	VB
cord-000372-wzwpyvll	563	15	optimal	optimal	JJ
cord-000372-wzwpyvll	563	16	cleavage	cleavage	NN
cord-000372-wzwpyvll	563	17	sequences	sequence	NNS
cord-000372-wzwpyvll	563	18	in	in	IN
cord-000372-wzwpyvll	563	19	the	the	DT
cord-000372-wzwpyvll	563	20	host	host	NN
cord-000372-wzwpyvll	563	21	proteome	proteome	NN
cord-000372-wzwpyvll	563	22	by	by	IN
cord-000372-wzwpyvll	563	23	implementing	implement	VBG
cord-000372-wzwpyvll	563	24	the	the	DT
cord-000372-wzwpyvll	563	25	proteolytic	proteolytic	JJ
cord-000372-wzwpyvll	563	26	sites	site	NNS
cord-000372-wzwpyvll	563	27	known	know	VBN
cord-000372-wzwpyvll	563	28	for	for	IN
cord-000372-wzwpyvll	563	29	newly	newly	RB
cord-000372-wzwpyvll	563	30	described	describe	VBN
cord-000372-wzwpyvll	563	31	2A	2a	CD
cord-000372-wzwpyvll	563	32	pro	pro	JJ
cord-000372-wzwpyvll	563	33	targets	target	NNS
cord-000372-wzwpyvll	563	34	.	.	.
cord-000372-wzwpyvll	564	1	Many	many	JJ
cord-000372-wzwpyvll	564	2	parameters	parameter	NNS
cord-000372-wzwpyvll	564	3	have	have	VBP
cord-000372-wzwpyvll	564	4	to	to	TO
cord-000372-wzwpyvll	564	5	be	be	VB
cord-000372-wzwpyvll	564	6	taken	take	VBN
cord-000372-wzwpyvll	564	7	into	into	IN
cord-000372-wzwpyvll	564	8	account	account	NN
cord-000372-wzwpyvll	564	9	,	,	,
cord-000372-wzwpyvll	564	10	including	include	VBG
cord-000372-wzwpyvll	564	11	the	the	DT
cord-000372-wzwpyvll	564	12	protein	protein	NN
cord-000372-wzwpyvll	564	13	localization	localization	NN
cord-000372-wzwpyvll	564	14	(	(	-LRB-
cord-000372-wzwpyvll	564	15	cytoplasmic	cytoplasmic	JJ
cord-000372-wzwpyvll	564	16	and	and	CC
cord-000372-wzwpyvll	564	17	nuclear	nuclear	JJ
cord-000372-wzwpyvll	564	18	protein	protein	NN
cord-000372-wzwpyvll	564	19	will	will	MD
cord-000372-wzwpyvll	564	20	be	be	VB
cord-000372-wzwpyvll	564	21	considered	consider	VBN
cord-000372-wzwpyvll	564	22	,	,	,
cord-000372-wzwpyvll	564	23	but	but	CC
cord-000372-wzwpyvll	564	24	not	not	RB
cord-000372-wzwpyvll	564	25	proteins	protein	VBZ
cord-000372-wzwpyvll	564	26	resident	resident	JJ
cord-000372-wzwpyvll	564	27	in	in	IN
cord-000372-wzwpyvll	564	28	the	the	DT
cord-000372-wzwpyvll	564	29	lumen	lumen	NN
cord-000372-wzwpyvll	564	30	of	of	IN
cord-000372-wzwpyvll	564	31	other	other	JJ
cord-000372-wzwpyvll	564	32	organelles	organelle	NNS
cord-000372-wzwpyvll	564	33	such	such	JJ
cord-000372-wzwpyvll	564	34	as	as	IN
cord-000372-wzwpyvll	564	35	RE	RE	NNP
cord-000372-wzwpyvll	564	36	or	or	CC
cord-000372-wzwpyvll	564	37	peroxisomes	peroxisome	NNS
cord-000372-wzwpyvll	564	38	)	)	-RRB-
cord-000372-wzwpyvll	564	39	,	,	,
cord-000372-wzwpyvll	564	40	the	the	DT
cord-000372-wzwpyvll	564	41	exposure	exposure	NN
cord-000372-wzwpyvll	564	42	of	of	IN
cord-000372-wzwpyvll	564	43	the	the	DT
cord-000372-wzwpyvll	564	44	cleavage	cleavage	NN
cord-000372-wzwpyvll	564	45	site	site	NN
cord-000372-wzwpyvll	564	46	to	to	IN
cord-000372-wzwpyvll	564	47	the	the	DT
cord-000372-wzwpyvll	564	48	solvent	solvent	NN
cord-000372-wzwpyvll	564	49	(	(	-LRB-
cord-000372-wzwpyvll	564	50	the	the	DT
cord-000372-wzwpyvll	564	51	sequence	sequence	NN
cord-000372-wzwpyvll	564	52	must	must	MD
cord-000372-wzwpyvll	564	53	be	be	VB
cord-000372-wzwpyvll	564	54	accessible	accessible	JJ
cord-000372-wzwpyvll	564	55	to	to	IN
cord-000372-wzwpyvll	564	56	the	the	DT
cord-000372-wzwpyvll	564	57	protease	protease	NN
cord-000372-wzwpyvll	564	58	)	)	-RRB-
cord-000372-wzwpyvll	564	59	,	,	,
cord-000372-wzwpyvll	564	60	and	and	CC
cord-000372-wzwpyvll	564	61	the	the	DT
cord-000372-wzwpyvll	564	62	secondary	secondary	JJ
cord-000372-wzwpyvll	564	63	structure	structure	NN
cord-000372-wzwpyvll	564	64	in	in	IN
cord-000372-wzwpyvll	564	65	which	which	WDT
cord-000372-wzwpyvll	564	66	the	the	DT
cord-000372-wzwpyvll	564	67	proteolytic	proteolytic	JJ
cord-000372-wzwpyvll	564	68	site	site	NN
cord-000372-wzwpyvll	564	69	is	be	VBZ
cord-000372-wzwpyvll	564	70	included	include	VBN
cord-000372-wzwpyvll	564	71	(	(	-LRB-
cord-000372-wzwpyvll	564	72	optimally	optimally	RB
cord-000372-wzwpyvll	564	73	,	,	,
cord-000372-wzwpyvll	564	74	unstructured	unstructured	JJ
cord-000372-wzwpyvll	564	75	regions	region	NNS
cord-000372-wzwpyvll	564	76	)	)	-RRB-
cord-000372-wzwpyvll	564	77	.	.	.
cord-000372-wzwpyvll	565	1	Potential	potential	JJ
cord-000372-wzwpyvll	565	2	targets	target	NNS
cord-000372-wzwpyvll	565	3	could	could	MD
cord-000372-wzwpyvll	565	4	be	be	VB
cord-000372-wzwpyvll	565	5	ordered	order	VBN
cord-000372-wzwpyvll	565	6	by	by	IN
cord-000372-wzwpyvll	565	7	their	-PRON-	PRP$
cord-000372-wzwpyvll	565	8	degree	degree	NN
cord-000372-wzwpyvll	565	9	of	of	IN
cord-000372-wzwpyvll	565	10	homology	homology	NN
cord-000372-wzwpyvll	565	11	with	with	IN
cord-000372-wzwpyvll	565	12	optimal	optimal	JJ
cord-000372-wzwpyvll	565	13	cleavage	cleavage	NN
cord-000372-wzwpyvll	565	14	sequences	sequence	NNS
cord-000372-wzwpyvll	565	15	,	,	,
cord-000372-wzwpyvll	565	16	as	as	RB
cord-000372-wzwpyvll	565	17	well	well	RB
cord-000372-wzwpyvll	565	18	as	as	IN
cord-000372-wzwpyvll	565	19	with	with	IN
cord-000372-wzwpyvll	565	20	the	the	DT
cord-000372-wzwpyvll	565	21	degree	degree	NN
cord-000372-wzwpyvll	565	22	in	in	IN
cord-000372-wzwpyvll	565	23	which	which	WDT
cord-000372-wzwpyvll	565	24	they	-PRON-	PRP
cord-000372-wzwpyvll	565	25	fulfill	fulfill	VBP
cord-000372-wzwpyvll	565	26	the	the	DT
cord-000372-wzwpyvll	565	27	above	above	JJ
cord-000372-wzwpyvll	565	28	prerequisites	prerequisite	NNS
cord-000372-wzwpyvll	565	29	.	.	.
cord-000372-wzwpyvll	566	1	On	on	IN
cord-000372-wzwpyvll	566	2	the	the	DT
cord-000372-wzwpyvll	566	3	other	other	JJ
cord-000372-wzwpyvll	566	4	hand	hand	NN
cord-000372-wzwpyvll	566	5	,	,	,
cord-000372-wzwpyvll	566	6	novel	novel	JJ
cord-000372-wzwpyvll	566	7	PV	PV	NNP
cord-000372-wzwpyvll	566	8	2A	2a	NN
cord-000372-wzwpyvll	566	9	pro	pro	JJ
cord-000372-wzwpyvll	566	10	targets	target	NNS
cord-000372-wzwpyvll	566	11	can	can	MD
cord-000372-wzwpyvll	566	12	be	be	VB
cord-000372-wzwpyvll	566	13	identified	identify	VBN
cord-000372-wzwpyvll	566	14	by	by	IN
cord-000372-wzwpyvll	566	15	proteomic	proteomic	JJ
cord-000372-wzwpyvll	566	16	tools	tool	NNS
cord-000372-wzwpyvll	566	17	such	such	JJ
cord-000372-wzwpyvll	566	18	as	as	IN
cord-000372-wzwpyvll	566	19	two	two	CD
cord-000372-wzwpyvll	566	20	-	-	HYPH
cord-000372-wzwpyvll	566	21	dimensional	dimensional	JJ
cord-000372-wzwpyvll	566	22	differential	differential	NN
cord-000372-wzwpyvll	566	23	gel	gel	NN
cord-000372-wzwpyvll	566	24	electrophoresis	electrophoresis	NN
cord-000372-wzwpyvll	566	25	(	(	-LRB-
cord-000372-wzwpyvll	566	26	DIGE	DIGE	NNP
cord-000372-wzwpyvll	566	27	)	)	-RRB-
cord-000372-wzwpyvll	566	28	or	or	CC
cord-000372-wzwpyvll	566	29	quantitative	quantitative	JJ
cord-000372-wzwpyvll	566	30	proteomics	proteomic	NNS
cord-000372-wzwpyvll	566	31	such	such	JJ
cord-000372-wzwpyvll	566	32	as	as	IN
cord-000372-wzwpyvll	566	33	stable	stable	JJ
cord-000372-wzwpyvll	566	34	isotope	isotope	NN
cord-000372-wzwpyvll	566	35	labeling	labeling	NN
cord-000372-wzwpyvll	566	36	by	by	IN
cord-000372-wzwpyvll	566	37	amino	amino	JJ
cord-000372-wzwpyvll	566	38	acids	acid	NNS
cord-000372-wzwpyvll	566	39	in	in	IN
cord-000372-wzwpyvll	566	40	cell	cell	NN
cord-000372-wzwpyvll	566	41	culture	culture	NN
cord-000372-wzwpyvll	566	42	(	(	-LRB-
cord-000372-wzwpyvll	566	43	SILAC	SILAC	NNP
cord-000372-wzwpyvll	566	44	)	)	-RRB-
cord-000372-wzwpyvll	566	45	coupled	couple	VBN
cord-000372-wzwpyvll	566	46	to	to	IN
cord-000372-wzwpyvll	566	47	monodimensional	monodimensional	JJ
cord-000372-wzwpyvll	566	48	electrophoresis	electrophoresis	NN
cord-000372-wzwpyvll	566	49	.	.	.
cord-000372-wzwpyvll	567	1	Following	follow	VBG
cord-000372-wzwpyvll	567	2	these	these	DT
cord-000372-wzwpyvll	567	3	two	two	CD
cord-000372-wzwpyvll	567	4	methods	method	NNS
cord-000372-wzwpyvll	567	5	,	,	,
cord-000372-wzwpyvll	567	6	it	-PRON-	PRP
cord-000372-wzwpyvll	567	7	will	will	MD
cord-000372-wzwpyvll	567	8	be	be	VB
cord-000372-wzwpyvll	567	9	feasible	feasible	JJ
cord-000372-wzwpyvll	567	10	to	to	TO
cord-000372-wzwpyvll	567	11	identify	identify	VB
cord-000372-wzwpyvll	567	12	proteins	protein	NNS
cord-000372-wzwpyvll	567	13	with	with	IN
cord-000372-wzwpyvll	567	14	reduced	reduce	VBN
cord-000372-wzwpyvll	567	15	levels	level	NNS
cord-000372-wzwpyvll	567	16	on	on	IN
cord-000372-wzwpyvll	567	17	2A	2a	CD
cord-000372-wzwpyvll	567	18	pro	pro	JJ
cord-000372-wzwpyvll	567	19	expression	expression	NN
cord-000372-wzwpyvll	567	20	and	and	CC
cord-000372-wzwpyvll	567	21	,	,	,
cord-000372-wzwpyvll	567	22	in	in	IN
cord-000372-wzwpyvll	567	23	addition	addition	NN
cord-000372-wzwpyvll	567	24	,	,	,
cord-000372-wzwpyvll	567	25	to	to	TO
cord-000372-wzwpyvll	567	26	detect	detect	VB
cord-000372-wzwpyvll	567	27	the	the	DT
cord-000372-wzwpyvll	567	28	cleavage	cleavage	NN
cord-000372-wzwpyvll	567	29	products	product	NNS
cord-000372-wzwpyvll	567	30	that	that	WDT
cord-000372-wzwpyvll	567	31	will	will	MD
cord-000372-wzwpyvll	567	32	appear	appear	VB
cord-000372-wzwpyvll	567	33	as	as	IN
cord-000372-wzwpyvll	567	34	lower	low	JJR
cord-000372-wzwpyvll	567	35	size	size	NN
cord-000372-wzwpyvll	567	36	peptides	peptide	NNS
cord-000372-wzwpyvll	567	37	.	.	.
cord-000372-wzwpyvll	568	1	By	by	IN
cord-000372-wzwpyvll	568	2	the	the	DT
cord-000372-wzwpyvll	568	3	uncovering	uncovering	NN
cord-000372-wzwpyvll	568	4	of	of	IN
cord-000372-wzwpyvll	568	5	novel	novel	JJ
cord-000372-wzwpyvll	568	6	2A	2a	CD
cord-000372-wzwpyvll	568	7	pro	pro	JJ
cord-000372-wzwpyvll	568	8	targets	target	NNS
cord-000372-wzwpyvll	568	9	we	-PRON-	PRP
cord-000372-wzwpyvll	568	10	will	will	MD
cord-000372-wzwpyvll	568	11	be	be	VB
cord-000372-wzwpyvll	568	12	able	able	JJ
cord-000372-wzwpyvll	568	13	to	to	TO
cord-000372-wzwpyvll	568	14	map	map	VB
cord-000372-wzwpyvll	568	15	the	the	DT
cord-000372-wzwpyvll	568	16	cellular	cellular	JJ
cord-000372-wzwpyvll	568	17	networks	network	NNS
cord-000372-wzwpyvll	568	18	impacted	impact	VBN
cord-000372-wzwpyvll	568	19	by	by	IN
cord-000372-wzwpyvll	568	20	PV	PV	NNP
cord-000372-wzwpyvll	568	21	2A	2a	CD
cord-000372-wzwpyvll	568	22	pro	pro	NNP
cord-000372-wzwpyvll	568	23	and	and	CC
cord-000372-wzwpyvll	568	24	to	to	TO
cord-000372-wzwpyvll	568	25	integrate	integrate	VB
cord-000372-wzwpyvll	568	26	them	-PRON-	PRP
cord-000372-wzwpyvll	568	27	in	in	IN
cord-000372-wzwpyvll	568	28	the	the	DT
cord-000372-wzwpyvll	568	29	context	context	NN
cord-000372-wzwpyvll	568	30	of	of	IN
cord-000372-wzwpyvll	568	31	PV	pv	NN
cord-000372-wzwpyvll	568	32	infection	infection	NN
cord-000372-wzwpyvll	568	33	.	.	.
cord-000372-wzwpyvll	569	1	In	in	IN
cord-000372-wzwpyvll	569	2	fact	fact	NN
cord-000372-wzwpyvll	569	3	,	,	,
cord-000372-wzwpyvll	569	4	the	the	DT
cord-000372-wzwpyvll	569	5	role	role	NN
cord-000372-wzwpyvll	569	6	of	of	IN
cord-000372-wzwpyvll	569	7	2A	2a	CD
cord-000372-wzwpyvll	569	8	pro	pro	JJ
cord-000372-wzwpyvll	569	9	hijacking	hijacking	NN
cord-000372-wzwpyvll	569	10	host	host	NN
cord-000372-wzwpyvll	569	11	processes	process	NNS
cord-000372-wzwpyvll	569	12	could	could	MD
cord-000372-wzwpyvll	569	13	be	be	VB
cord-000372-wzwpyvll	569	14	potentially	potentially	RB
cord-000372-wzwpyvll	569	15	expanded	expand	VBN
cord-000372-wzwpyvll	569	16	to	to	IN
cord-000372-wzwpyvll	569	17	other	other	JJ
cord-000372-wzwpyvll	569	18	cellular	cellular	JJ
cord-000372-wzwpyvll	569	19	pathways	pathway	NNS
cord-000372-wzwpyvll	569	20	with	with	IN
cord-000372-wzwpyvll	569	21	direct	direct	JJ
cord-000372-wzwpyvll	569	22	impact	impact	NN
cord-000372-wzwpyvll	569	23	on	on	IN
cord-000372-wzwpyvll	569	24	control	control	NN
cord-000372-wzwpyvll	569	25	of	of	IN
cord-000372-wzwpyvll	569	26	viral	viral	JJ
cord-000372-wzwpyvll	569	27	infection	infection	NN
cord-000372-wzwpyvll	569	28	.	.	.
cord-000372-wzwpyvll	570	1	Such	such	JJ
cord-000372-wzwpyvll	570	2	knowledge	knowledge	NN
cord-000372-wzwpyvll	570	3	will	will	MD
cord-000372-wzwpyvll	570	4	provide	provide	VB
cord-000372-wzwpyvll	570	5	more	more	JJR
cord-000372-wzwpyvll	570	6	insight	insight	NN
cord-000372-wzwpyvll	570	7	into	into	IN
cord-000372-wzwpyvll	570	8	our	-PRON-	PRP$
cord-000372-wzwpyvll	570	9	understanding	understanding	NN
cord-000372-wzwpyvll	570	10	of	of	IN
cord-000372-wzwpyvll	570	11	the	the	DT
cord-000372-wzwpyvll	570	12	cytopathogenicity	cytopathogenicity	NN
cord-000372-wzwpyvll	570	13	of	of	IN
cord-000372-wzwpyvll	570	14	viral	viral	JJ
cord-000372-wzwpyvll	570	15	proteases	protease	NNS
cord-000372-wzwpyvll	570	16	at	at	IN
cord-000372-wzwpyvll	570	17	the	the	DT
cord-000372-wzwpyvll	570	18	molecular	molecular	JJ
cord-000372-wzwpyvll	570	19	level	level	NN
cord-000372-wzwpyvll	570	20	.	.	.
cord-000372-wzwpyvll	571	1	Viral	viral	JJ
cord-000372-wzwpyvll	571	2	proteases	protease	NNS
cord-000372-wzwpyvll	571	3	Structure	structure	NN
cord-000372-wzwpyvll	571	4	and	and	CC
cord-000372-wzwpyvll	571	5	function	function	NN
cord-000372-wzwpyvll	571	6	of	of	IN
cord-000372-wzwpyvll	571	7	picornavirus	picornavirus	NNP
cord-000372-wzwpyvll	571	8	proteinases	proteinases	NNP
cord-000372-wzwpyvll	571	9	HIV-1	HIV-1	NNP
cord-000372-wzwpyvll	571	10	:	:	:
cord-000372-wzwpyvll	571	11	fifteen	fifteen	CD
cord-000372-wzwpyvll	571	12	proteins	protein	NNS
cord-000372-wzwpyvll	571	13	and	and	CC
cord-000372-wzwpyvll	571	14	an	an	DT
cord-000372-wzwpyvll	571	15	RNA	rna	NN
cord-000372-wzwpyvll	572	1	The	the	DT
cord-000372-wzwpyvll	572	2	structures	structure	NNS
cord-000372-wzwpyvll	572	3	of	of	IN
cord-000372-wzwpyvll	572	4	picornaviral	picornaviral	NNP
cord-000372-wzwpyvll	572	5	proteinases	proteinases	NNP
cord-000372-wzwpyvll	572	6	Organization	Organization	NNP
cord-000372-wzwpyvll	572	7	and	and	CC
cord-000372-wzwpyvll	572	8	expression	expression	NN
cord-000372-wzwpyvll	572	9	of	of	IN
cord-000372-wzwpyvll	572	10	calicivirus	calicivirus	JJ
cord-000372-wzwpyvll	572	11	genes	gene	NNS
cord-000372-wzwpyvll	572	12	Proteolytic	proteolytic	JJ
cord-000372-wzwpyvll	572	13	processing	processing	NN
cord-000372-wzwpyvll	572	14	of	of	IN
cord-000372-wzwpyvll	572	15	foamy	foamy	JJ
cord-000372-wzwpyvll	572	16	virus	virus	NN
cord-000372-wzwpyvll	572	17	Gag	gag	NN
cord-000372-wzwpyvll	572	18	and	and	CC
cord-000372-wzwpyvll	572	19	Pol	Pol	NNP
cord-000372-wzwpyvll	572	20	proteins	protein	NNS
cord-000372-wzwpyvll	572	21	New	New	NNP
cord-000372-wzwpyvll	572	22	insights	insight	NNS
cord-000372-wzwpyvll	572	23	into	into	IN
cord-000372-wzwpyvll	572	24	flavivirus	flavivirus	JJ
cord-000372-wzwpyvll	572	25	nonstructural	nonstructural	JJ
cord-000372-wzwpyvll	572	26	protein	protein	NN
cord-000372-wzwpyvll	572	27	5	5	CD
cord-000372-wzwpyvll	572	28	Poliovirus	Poliovirus	NNP
cord-000372-wzwpyvll	572	29	,	,	,
cord-000372-wzwpyvll	572	30	pathogenesis	pathogenesis	NN
cord-000372-wzwpyvll	572	31	of	of	IN
cord-000372-wzwpyvll	572	32	poliomyelitis	poliomyelitis	NN
cord-000372-wzwpyvll	572	33	,	,	,
cord-000372-wzwpyvll	572	34	and	and	CC
cord-000372-wzwpyvll	572	35	apoptosis	apoptosis	NN
cord-000372-wzwpyvll	572	36	Poliovirus	Poliovirus	NNP
cord-000372-wzwpyvll	572	37	and	and	CC
cord-000372-wzwpyvll	572	38	apoptosis	apoptosis	NN
cord-000372-wzwpyvll	572	39	Induction	Induction	NNP
cord-000372-wzwpyvll	572	40	of	of	IN
cord-000372-wzwpyvll	572	41	membrane	membrane	NN
cord-000372-wzwpyvll	572	42	proliferation	proliferation	NN
cord-000372-wzwpyvll	572	43	by	by	IN
cord-000372-wzwpyvll	572	44	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	572	45	proteins	protein	NNS
cord-000372-wzwpyvll	572	46	2C	2C	NNP
cord-000372-wzwpyvll	572	47	and	and	CC
cord-000372-wzwpyvll	572	48	2BC	2BC	NNP
cord-000372-wzwpyvll	572	49	Two	two	CD
cord-000372-wzwpyvll	572	50	types	type	NNS
cord-000372-wzwpyvll	572	51	of	of	IN
cord-000372-wzwpyvll	572	52	death	death	NN
cord-000372-wzwpyvll	572	53	of	of	IN
cord-000372-wzwpyvll	572	54	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	572	55	-	-	HYPH
cord-000372-wzwpyvll	572	56	infected	infect	VBN
cord-000372-wzwpyvll	572	57	cells	cell	NNS
cord-000372-wzwpyvll	572	58	:	:	:
cord-000372-wzwpyvll	573	1	caspase	caspase	NN
cord-000372-wzwpyvll	573	2	involvement	involvement	NN
cord-000372-wzwpyvll	573	3	in	in	IN
cord-000372-wzwpyvll	573	4	the	the	DT
cord-000372-wzwpyvll	573	5	apoptosis	apoptosis	NN
cord-000372-wzwpyvll	573	6	but	but	CC
cord-000372-wzwpyvll	573	7	not	not	RB
cord-000372-wzwpyvll	573	8	cytopathic	cytopathic	JJ
cord-000372-wzwpyvll	573	9	effect	effect	NN
cord-000372-wzwpyvll	573	10	Individual	individual	JJ
cord-000372-wzwpyvll	573	11	expression	expression	NN
cord-000372-wzwpyvll	573	12	of	of	IN
cord-000372-wzwpyvll	573	13	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	573	14	2A	2a	CD
cord-000372-wzwpyvll	573	15	and	and	CC
cord-000372-wzwpyvll	573	16	3C	3C	NNP
cord-000372-wzwpyvll	573	17	induces	induce	VBZ
cord-000372-wzwpyvll	573	18	activation	activation	NN
cord-000372-wzwpyvll	573	19	of	of	IN
cord-000372-wzwpyvll	573	20	caspase-3	caspase-3	NNP
cord-000372-wzwpyvll	573	21	and	and	CC
cord-000372-wzwpyvll	573	22	PARP	PARP	NNP
cord-000372-wzwpyvll	573	23	cleavage	cleavage	NN
cord-000372-wzwpyvll	573	24	in	in	IN
cord-000372-wzwpyvll	573	25	HeLa	HeLa	NNP
cord-000372-wzwpyvll	573	26	cells	cell	NNS
cord-000372-wzwpyvll	573	27	Picornavirus	Picornavirus	NNP
cord-000372-wzwpyvll	573	28	RNA	RNA	NNP
cord-000372-wzwpyvll	573	29	translation	translation	NN
cord-000372-wzwpyvll	573	30	:	:	:
cord-000372-wzwpyvll	573	31	roles	role	NNS
cord-000372-wzwpyvll	573	32	for	for	IN
cord-000372-wzwpyvll	573	33	cellular	cellular	JJ
cord-000372-wzwpyvll	573	34	proteins	protein	NNS
cord-000372-wzwpyvll	573	35	Translational	translational	JJ
cord-000372-wzwpyvll	573	36	control	control	NN
cord-000372-wzwpyvll	573	37	by	by	IN
cord-000372-wzwpyvll	573	38	viral	viral	JJ
cord-000372-wzwpyvll	573	39	proteinases	proteinases	NNP
cord-000372-wzwpyvll	573	40	Effects	effect	NNS
cord-000372-wzwpyvll	573	41	of	of	IN
cord-000372-wzwpyvll	573	42	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	573	43	infection	infection	NN
cord-000372-wzwpyvll	573	44	on	on	IN
cord-000372-wzwpyvll	573	45	nucleo	nucleo	JJ
cord-000372-wzwpyvll	573	46	-	-	JJ
cord-000372-wzwpyvll	573	47	cytoplasmic	cytoplasmic	JJ
cord-000372-wzwpyvll	573	48	trafficking	trafficking	NN
cord-000372-wzwpyvll	573	49	and	and	CC
cord-000372-wzwpyvll	574	1	nuclear	nuclear	JJ
cord-000372-wzwpyvll	574	2	pore	pore	NN
cord-000372-wzwpyvll	574	3	complex	complex	JJ
cord-000372-wzwpyvll	574	4	composition	composition	NN
cord-000372-wzwpyvll	574	5	Differential	differential	NN
cord-000372-wzwpyvll	574	6	targeting	targeting	NN
cord-000372-wzwpyvll	574	7	of	of	IN
cord-000372-wzwpyvll	574	8	nuclear	nuclear	JJ
cord-000372-wzwpyvll	574	9	pore	pore	NN
cord-000372-wzwpyvll	574	10	complex	complex	NN
cord-000372-wzwpyvll	574	11	proteins	protein	NNS
cord-000372-wzwpyvll	574	12	in	in	IN
cord-000372-wzwpyvll	574	13	poliovirusinfected	poliovirusinfecte	VBN
cord-000372-wzwpyvll	574	14	cells	cell	NNS
cord-000372-wzwpyvll	575	1	RNA	RNA	NNP
cord-000372-wzwpyvll	575	2	nuclear	nuclear	JJ
cord-000372-wzwpyvll	575	3	export	export	NN
cord-000372-wzwpyvll	575	4	is	be	VBZ
cord-000372-wzwpyvll	575	5	blocked	block	VBN
cord-000372-wzwpyvll	575	6	by	by	IN
cord-000372-wzwpyvll	575	7	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	575	8	2A	2a	CD
cord-000372-wzwpyvll	575	9	protease	protease	NN
cord-000372-wzwpyvll	575	10	and	and	CC
cord-000372-wzwpyvll	575	11	is	be	VBZ
cord-000372-wzwpyvll	575	12	concomitant	concomitant	JJ
cord-000372-wzwpyvll	575	13	with	with	IN
cord-000372-wzwpyvll	575	14	nucleoporin	nucleoporin	NNP
cord-000372-wzwpyvll	575	15	cleavage	cleavage	NN
cord-000372-wzwpyvll	576	1	The	the	DT
cord-000372-wzwpyvll	576	2	pathogenesis	pathogenesis	NN
cord-000372-wzwpyvll	576	3	of	of	IN
cord-000372-wzwpyvll	576	4	poliomyelitis	poliomyelitis	NN
cord-000372-wzwpyvll	576	5	:	:	:
cord-000372-wzwpyvll	576	6	what	what	WP
cord-000372-wzwpyvll	576	7	we	-PRON-	PRP
cord-000372-wzwpyvll	576	8	do	do	VBP
cord-000372-wzwpyvll	576	9	n't	not	RB
cord-000372-wzwpyvll	576	10	know	know	VB
cord-000372-wzwpyvll	576	11	Poliovirus	Poliovirus	NNP
cord-000372-wzwpyvll	576	12	cell	cell	NN
cord-000372-wzwpyvll	576	13	entry	entry	NN
cord-000372-wzwpyvll	576	14	:	:	:
cord-000372-wzwpyvll	576	15	common	common	JJ
cord-000372-wzwpyvll	576	16	structural	structural	JJ
cord-000372-wzwpyvll	576	17	themes	theme	NNS
cord-000372-wzwpyvll	576	18	in	in	IN
cord-000372-wzwpyvll	576	19	viral	viral	JJ
cord-000372-wzwpyvll	576	20	cell	cell	NN
cord-000372-wzwpyvll	576	21	entry	entry	NN
cord-000372-wzwpyvll	576	22	pathways	pathway	NNS
cord-000372-wzwpyvll	576	23	One	one	CD
cord-000372-wzwpyvll	576	24	hundred	hundred	CD
cord-000372-wzwpyvll	576	25	years	year	NNS
cord-000372-wzwpyvll	576	26	of	of	IN
cord-000372-wzwpyvll	576	27	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	576	28	pathogenesis	pathogenesis	NN
cord-000372-wzwpyvll	576	29	Genetics	genetic	NNS
cord-000372-wzwpyvll	576	30	of	of	IN
cord-000372-wzwpyvll	576	31	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	576	32	Picornavirus	Picornavirus	NNP
cord-000372-wzwpyvll	576	33	genome	genome	NN
cord-000372-wzwpyvll	576	34	:	:	:
cord-000372-wzwpyvll	576	35	an	an	DT
cord-000372-wzwpyvll	576	36	overview	overview	NN
cord-000372-wzwpyvll	576	37	Processing	processing	NN
cord-000372-wzwpyvll	576	38	determinants	determinant	NNS
cord-000372-wzwpyvll	576	39	and	and	CC
cord-000372-wzwpyvll	576	40	functions	function	NNS
cord-000372-wzwpyvll	576	41	of	of	IN
cord-000372-wzwpyvll	576	42	cleavage	cleavage	NN
cord-000372-wzwpyvll	576	43	products	product	NNS
cord-000372-wzwpyvll	576	44	of	of	IN
cord-000372-wzwpyvll	576	45	picornavirus	picornavirus	NNP
cord-000372-wzwpyvll	576	46	polyproteins	polyproteins	NNP
cord-000372-wzwpyvll	576	47	Proteolytic	Proteolytic	NNP
cord-000372-wzwpyvll	576	48	processing	processing	NN
cord-000372-wzwpyvll	576	49	of	of	IN
cord-000372-wzwpyvll	576	50	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	576	51	polyprotein	polyprotein	NN
cord-000372-wzwpyvll	576	52	:	:	:
cord-000372-wzwpyvll	576	53	elimination	elimination	NN
cord-000372-wzwpyvll	576	54	of	of	IN
cord-000372-wzwpyvll	576	55	2A(pro)-mediated	2a(pro)-mediated	CD
cord-000372-wzwpyvll	576	56	,	,	,
cord-000372-wzwpyvll	576	57	alternative	alternative	JJ
cord-000372-wzwpyvll	576	58	cleavage	cleavage	NN
cord-000372-wzwpyvll	576	59	of	of	IN
cord-000372-wzwpyvll	576	60	polypeptide	polypeptide	NN
cord-000372-wzwpyvll	576	61	3CD	3cd	CD
cord-000372-wzwpyvll	576	62	by	by	IN
cord-000372-wzwpyvll	576	63	in	in	FW
cord-000372-wzwpyvll	576	64	vitro	vitro	FW
cord-000372-wzwpyvll	576	65	mutagenesis	mutagenesis	NN
cord-000372-wzwpyvll	577	1	Poliovirus	Poliovirus	NNP
cord-000372-wzwpyvll	577	2	RNA	RNA	NNP
cord-000372-wzwpyvll	577	3	-	-	HYPH
cord-000372-wzwpyvll	577	4	dependent	dependent	JJ
cord-000372-wzwpyvll	577	5	RNA	RNA	NNP
cord-000372-wzwpyvll	577	6	polymerase	polymerase	NN
cord-000372-wzwpyvll	577	7	(	(	-LRB-
cord-000372-wzwpyvll	577	8	3Dpol	3Dpol	NNP
cord-000372-wzwpyvll	577	9	)	)	-RRB-
cord-000372-wzwpyvll	577	10	:	:	:
cord-000372-wzwpyvll	577	11	structure	structure	NN
cord-000372-wzwpyvll	577	12	,	,	,
cord-000372-wzwpyvll	577	13	function	function	NN
cord-000372-wzwpyvll	577	14	,	,	,
cord-000372-wzwpyvll	577	15	and	and	CC
cord-000372-wzwpyvll	577	16	mechanism	mechanism	NN
cord-000372-wzwpyvll	577	17	Possible	possible	JJ
cord-000372-wzwpyvll	577	18	Unifying	unifying	JJ
cord-000372-wzwpyvll	577	19	mechanism	mechanism	NN
cord-000372-wzwpyvll	577	20	of	of	IN
cord-000372-wzwpyvll	577	21	picornavirus	picornavirus	NNP
cord-000372-wzwpyvll	577	22	genome	genome	NNP
cord-000372-wzwpyvll	577	23	replication	replication	NN
cord-000372-wzwpyvll	577	24	Protein	Protein	NNP
cord-000372-wzwpyvll	577	25	-	-	HYPH
cord-000372-wzwpyvll	577	26	primed	prime	VBN
cord-000372-wzwpyvll	577	27	RNA	RNA	NNP
cord-000372-wzwpyvll	577	28	synthesis	synthesis	NN
cord-000372-wzwpyvll	577	29	by	by	IN
cord-000372-wzwpyvll	577	30	purified	purify	VBN
cord-000372-wzwpyvll	577	31	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	577	32	RNA	RNA	NNP
cord-000372-wzwpyvll	577	33	polymerase	polymerase	NN
cord-000372-wzwpyvll	577	34	Inhibitors	Inhibitors	NNP
cord-000372-wzwpyvll	577	35	of	of	IN
cord-000372-wzwpyvll	577	36	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	577	37	uncoating	uncoate	VBG
cord-000372-wzwpyvll	577	38	efficiently	efficiently	RB
cord-000372-wzwpyvll	577	39	block	block	VBP
cord-000372-wzwpyvll	577	40	the	the	DT
cord-000372-wzwpyvll	577	41	early	early	JJ
cord-000372-wzwpyvll	577	42	membrane	membrane	NN
cord-000372-wzwpyvll	577	43	permeabilization	permeabilization	NN
cord-000372-wzwpyvll	577	44	induced	induce	VBN
cord-000372-wzwpyvll	577	45	by	by	IN
cord-000372-wzwpyvll	577	46	virus	virus	NN
cord-000372-wzwpyvll	577	47	particles	particle	NNS
cord-000372-wzwpyvll	577	48	Viral	viral	JJ
cord-000372-wzwpyvll	577	49	translation	translation	NN
cord-000372-wzwpyvll	577	50	is	be	VBZ
cord-000372-wzwpyvll	577	51	coupled	couple	VBN
cord-000372-wzwpyvll	577	52	to	to	IN
cord-000372-wzwpyvll	577	53	transcription	transcription	NN
cord-000372-wzwpyvll	577	54	in	in	IN
cord-000372-wzwpyvll	577	55	sindbis	sindbis	NN
cord-000372-wzwpyvll	577	56	virus	virus	NN
cord-000372-wzwpyvll	577	57	-	-	HYPH
cord-000372-wzwpyvll	577	58	infected	infect	VBN
cord-000372-wzwpyvll	577	59	cells	cell	NNS
cord-000372-wzwpyvll	577	60	Phospholipid	phospholipid	NN
cord-000372-wzwpyvll	577	61	biosynthesis	biosynthesis	NN
cord-000372-wzwpyvll	577	62	and	and	CC
cord-000372-wzwpyvll	577	63	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	577	64	genome	genome	NN
cord-000372-wzwpyvll	577	65	replication	replication	NN
cord-000372-wzwpyvll	577	66	,	,	,
cord-000372-wzwpyvll	577	67	two	two	CD
cord-000372-wzwpyvll	577	68	coupled	couple	VBN
cord-000372-wzwpyvll	577	69	phenomena	phenomena	NN
cord-000372-wzwpyvll	577	70	Effects	effect	NNS
cord-000372-wzwpyvll	577	71	of	of	IN
cord-000372-wzwpyvll	577	72	viral	viral	JJ
cord-000372-wzwpyvll	577	73	replication	replication	NN
cord-000372-wzwpyvll	577	74	on	on	IN
cord-000372-wzwpyvll	577	75	cellular	cellular	JJ
cord-000372-wzwpyvll	577	76	membrane	membrane	NN
cord-000372-wzwpyvll	577	77	metabolism	metabolism	NN
cord-000372-wzwpyvll	577	78	and	and	CC
cord-000372-wzwpyvll	577	79	function	function	VB
cord-000372-wzwpyvll	577	80	Viroporinmediated	Viroporinmediated	NNP
cord-000372-wzwpyvll	577	81	membrane	membrane	NN
cord-000372-wzwpyvll	577	82	permeabilization	permeabilization	NN
cord-000372-wzwpyvll	577	83	:	:	:
cord-000372-wzwpyvll	577	84	pore	pore	NN
cord-000372-wzwpyvll	577	85	formation	formation	NN
cord-000372-wzwpyvll	577	86	by	by	IN
cord-000372-wzwpyvll	577	87	nonstructural	nonstructural	JJ
cord-000372-wzwpyvll	577	88	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	577	89	2B	2b	CD
cord-000372-wzwpyvll	577	90	protein	protein	NN
cord-000372-wzwpyvll	577	91	Viroporins	Viroporins	NNP
cord-000372-wzwpyvll	577	92	Primary	Primary	NNP
cord-000372-wzwpyvll	577	93	structure	structure	NN
cord-000372-wzwpyvll	577	94	,	,	,
cord-000372-wzwpyvll	577	95	gene	gene	NN
cord-000372-wzwpyvll	577	96	organization	organization	NN
cord-000372-wzwpyvll	577	97	and	and	CC
cord-000372-wzwpyvll	577	98	polypeptide	polypeptide	JJ
cord-000372-wzwpyvll	577	99	expression	expression	NN
cord-000372-wzwpyvll	577	100	of	of	IN
cord-000372-wzwpyvll	577	101	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	577	102	RNA	RNA	NNP
cord-000372-wzwpyvll	577	103	Three	Three	NNP
cord-000372-wzwpyvll	577	104	-	-	HYPH
cord-000372-wzwpyvll	577	105	dimensional	dimensional	JJ
cord-000372-wzwpyvll	577	106	structure	structure	NN
cord-000372-wzwpyvll	577	107	of	of	IN
cord-000372-wzwpyvll	577	108	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	577	109	at	at	IN
cord-000372-wzwpyvll	577	110	2.9Å	2.9Å	NNP
cord-000372-wzwpyvll	577	111	resolution	resolution	NN
cord-000372-wzwpyvll	577	112	Internal	internal	JJ
cord-000372-wzwpyvll	577	113	initiation	initiation	NN
cord-000372-wzwpyvll	577	114	of	of	IN
cord-000372-wzwpyvll	577	115	translation	translation	NN
cord-000372-wzwpyvll	577	116	of	of	IN
cord-000372-wzwpyvll	577	117	eukaryotic	eukaryotic	JJ
cord-000372-wzwpyvll	577	118	mRNA	mRNA	NNP
cord-000372-wzwpyvll	577	119	directed	direct	VBN
cord-000372-wzwpyvll	577	120	by	by	IN
cord-000372-wzwpyvll	577	121	a	a	DT
cord-000372-wzwpyvll	577	122	sequence	sequence	NN
cord-000372-wzwpyvll	577	123	derived	derive	VBN
cord-000372-wzwpyvll	577	124	from	from	IN
cord-000372-wzwpyvll	577	125	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	577	126	RNA	RNA	NNP
cord-000372-wzwpyvll	577	127	Cell	Cell	NNP
cord-000372-wzwpyvll	577	128	-	-	HYPH
cord-000372-wzwpyvll	577	129	free	free	JJ
cord-000372-wzwpyvll	577	130	,	,	,
cord-000372-wzwpyvll	577	131	de	de	FW
cord-000372-wzwpyvll	577	132	novo	novo	NNP
cord-000372-wzwpyvll	577	133	synthesis	synthesis	NN
cord-000372-wzwpyvll	577	134	of	of	IN
cord-000372-wzwpyvll	577	135	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	577	136	Synthetic	synthetic	JJ
cord-000372-wzwpyvll	577	137	viruses	virus	NNS
cord-000372-wzwpyvll	577	138	:	:	:
cord-000372-wzwpyvll	577	139	a	a	DT
cord-000372-wzwpyvll	577	140	new	new	JJ
cord-000372-wzwpyvll	577	141	opportunity	opportunity	NN
cord-000372-wzwpyvll	577	142	to	to	TO
cord-000372-wzwpyvll	577	143	understand	understand	VB
cord-000372-wzwpyvll	577	144	and	and	CC
cord-000372-wzwpyvll	577	145	prevent	prevent	VB
cord-000372-wzwpyvll	577	146	viral	viral	JJ
cord-000372-wzwpyvll	577	147	disease	disease	NN
cord-000372-wzwpyvll	577	148	Inhibition	inhibition	NN
cord-000372-wzwpyvll	577	149	of	of	IN
cord-000372-wzwpyvll	577	150	HeLa	HeLa	NNP
cord-000372-wzwpyvll	577	151	cell	cell	NN
cord-000372-wzwpyvll	577	152	protein	protein	NN
cord-000372-wzwpyvll	577	153	synthesis	synthesis	NN
cord-000372-wzwpyvll	577	154	following	follow	VBG
cord-000372-wzwpyvll	577	155	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	577	156	infection	infection	NN
cord-000372-wzwpyvll	577	157	correlates	correlate	VBZ
cord-000372-wzwpyvll	577	158	with	with	IN
cord-000372-wzwpyvll	577	159	the	the	DT
cord-000372-wzwpyvll	577	160	proteolysis	proteolysis	NN
cord-000372-wzwpyvll	577	161	of	of	IN
cord-000372-wzwpyvll	577	162	a	a	DT
cord-000372-wzwpyvll	577	163	220,000-dalton	220,000-dalton	CD
cord-000372-wzwpyvll	577	164	polypeptide	polypeptide	NN
cord-000372-wzwpyvll	577	165	associated	associate	VBN
cord-000372-wzwpyvll	577	166	with	with	IN
cord-000372-wzwpyvll	577	167	eucaryotc	eucaryotc	NNP
cord-000372-wzwpyvll	577	168	initiation	initiation	NNP
cord-000372-wzwpyvll	577	169	factor	factor	NN
cord-000372-wzwpyvll	577	170	3	3	CD
cord-000372-wzwpyvll	577	171	and	and	CC
cord-000372-wzwpyvll	577	172	a	a	DT
cord-000372-wzwpyvll	577	173	cap	cap	NN
cord-000372-wzwpyvll	577	174	binding	bind	VBG
cord-000372-wzwpyvll	577	175	protein	protein	NN
cord-000372-wzwpyvll	577	176	complex	complex	NN
cord-000372-wzwpyvll	577	177	Virus	virus	NN
cord-000372-wzwpyvll	577	178	-	-	HYPH
cord-000372-wzwpyvll	577	179	encoded	encode	VBN
cord-000372-wzwpyvll	577	180	proteinases	proteinase	NNS
cord-000372-wzwpyvll	577	181	of	of	IN
cord-000372-wzwpyvll	577	182	the	the	DT
cord-000372-wzwpyvll	577	183	picornavirus	picornavirus	NNP
cord-000372-wzwpyvll	577	184	super	super	NNP
cord-000372-wzwpyvll	577	185	-	-	NNP
cord-000372-wzwpyvll	577	186	group	group	NNP
cord-000372-wzwpyvll	577	187	Genome	Genome	NNP
cord-000372-wzwpyvll	577	188	organization	organization	NN
cord-000372-wzwpyvll	577	189	and	and	CC
cord-000372-wzwpyvll	577	190	encoded	encode	VBD
cord-000372-wzwpyvll	577	191	proteins	protein	NNS
cord-000372-wzwpyvll	577	192	Structure	Structure	NNP
cord-000372-wzwpyvll	577	193	of	of	IN
cord-000372-wzwpyvll	577	194	the	the	DT
cord-000372-wzwpyvll	577	195	foot	foot	NN
cord-000372-wzwpyvll	577	196	-	-	HYPH
cord-000372-wzwpyvll	577	197	and	and	CC
cord-000372-wzwpyvll	577	198	-	-	HYPH
cord-000372-wzwpyvll	577	199	mouth	mouth	NN
cord-000372-wzwpyvll	577	200	disease	disease	NN
cord-000372-wzwpyvll	577	201	virus	virus	NN
cord-000372-wzwpyvll	577	202	leader	leader	NN
cord-000372-wzwpyvll	577	203	protease	protease	NN
cord-000372-wzwpyvll	577	204	:	:	:
cord-000372-wzwpyvll	577	205	a	a	DT
cord-000372-wzwpyvll	577	206	papain	papain	NN
cord-000372-wzwpyvll	577	207	-	-	HYPH
cord-000372-wzwpyvll	577	208	like	like	IN
cord-000372-wzwpyvll	577	209	fold	fold	NN
cord-000372-wzwpyvll	577	210	adapted	adapt	VBN
cord-000372-wzwpyvll	577	211	for	for	IN
cord-000372-wzwpyvll	578	1	self	self	NN
cord-000372-wzwpyvll	578	2	-	-	HYPH
cord-000372-wzwpyvll	578	3	processing	processing	NN
cord-000372-wzwpyvll	578	4	and	and	CC
cord-000372-wzwpyvll	578	5	eIF4	eIF4	VBZ
cord-000372-wzwpyvll	578	6	G	G	NNP
cord-000372-wzwpyvll	578	7	recognition	recognition	NN
cord-000372-wzwpyvll	578	8	Structural	structural	JJ
cord-000372-wzwpyvll	578	9	and	and	CC
cord-000372-wzwpyvll	578	10	biochemical	biochemical	JJ
cord-000372-wzwpyvll	578	11	features	feature	NNS
cord-000372-wzwpyvll	578	12	distinguish	distinguish	VBP
cord-000372-wzwpyvll	578	13	the	the	DT
cord-000372-wzwpyvll	578	14	foot	foot	NN
cord-000372-wzwpyvll	578	15	-	-	HYPH
cord-000372-wzwpyvll	578	16	and	and	CC
cord-000372-wzwpyvll	578	17	-	-	HYPH
cord-000372-wzwpyvll	578	18	mouth	mouth	NN
cord-000372-wzwpyvll	578	19	disease	disease	NN
cord-000372-wzwpyvll	578	20	virus	virus	NN
cord-000372-wzwpyvll	578	21	leader	leader	NN
cord-000372-wzwpyvll	578	22	proteinase	proteinase	NN
cord-000372-wzwpyvll	578	23	from	from	IN
cord-000372-wzwpyvll	578	24	other	other	JJ
cord-000372-wzwpyvll	578	25	papain	papain	NN
cord-000372-wzwpyvll	578	26	-	-	HYPH
cord-000372-wzwpyvll	578	27	like	like	JJ
cord-000372-wzwpyvll	578	28	enzymes	enzyme	NNS
cord-000372-wzwpyvll	579	1	The	the	DT
cord-000372-wzwpyvll	579	2	foot	foot	NN
cord-000372-wzwpyvll	579	3	-	-	HYPH
cord-000372-wzwpyvll	579	4	and	and	CC
cord-000372-wzwpyvll	579	5	-	-	HYPH
cord-000372-wzwpyvll	579	6	mouth	mouth	NN
cord-000372-wzwpyvll	579	7	disease	disease	NN
cord-000372-wzwpyvll	579	8	virus	virus	NN
cord-000372-wzwpyvll	579	9	leader	leader	NN
cord-000372-wzwpyvll	579	10	proteinase	proteinase	NN
cord-000372-wzwpyvll	579	11	gene	gene	NN
cord-000372-wzwpyvll	579	12	is	be	VBZ
cord-000372-wzwpyvll	579	13	not	not	RB
cord-000372-wzwpyvll	579	14	required	require	VBN
cord-000372-wzwpyvll	579	15	for	for	IN
cord-000372-wzwpyvll	579	16	viral	viral	JJ
cord-000372-wzwpyvll	579	17	replication	replication	NN
cord-000372-wzwpyvll	580	1	The	the	DT
cord-000372-wzwpyvll	580	2	leader	leader	NN
cord-000372-wzwpyvll	580	3	proteinase	proteinase	NN
cord-000372-wzwpyvll	580	4	of	of	IN
cord-000372-wzwpyvll	580	5	foot	foot	NN
cord-000372-wzwpyvll	580	6	-	-	HYPH
cord-000372-wzwpyvll	580	7	and	and	CC
cord-000372-wzwpyvll	580	8	-	-	HYPH
cord-000372-wzwpyvll	580	9	mouth	mouth	NN
cord-000372-wzwpyvll	580	10	disease	disease	NN
cord-000372-wzwpyvll	580	11	virus	virus	NN
cord-000372-wzwpyvll	580	12	inhibits	inhibit	VBZ
cord-000372-wzwpyvll	580	13	the	the	DT
cord-000372-wzwpyvll	580	14	induction	induction	NN
cord-000372-wzwpyvll	580	15	of	of	IN
cord-000372-wzwpyvll	580	16	beta	beta	NNP
cord-000372-wzwpyvll	580	17	interferon	interferon	NN
cord-000372-wzwpyvll	580	18	mRNA	mRNA	NNP
cord-000372-wzwpyvll	580	19	and	and	CC
cord-000372-wzwpyvll	580	20	blocks	block	VBZ
cord-000372-wzwpyvll	580	21	the	the	DT
cord-000372-wzwpyvll	580	22	host	host	NN
cord-000372-wzwpyvll	580	23	innate	innate	JJ
cord-000372-wzwpyvll	580	24	immune	immune	JJ
cord-000372-wzwpyvll	580	25	response	response	NN
cord-000372-wzwpyvll	581	1	A	a	DT
cord-000372-wzwpyvll	581	2	conserved	conserved	JJ
cord-000372-wzwpyvll	581	3	domain	domain	NN
cord-000372-wzwpyvll	581	4	in	in	IN
cord-000372-wzwpyvll	581	5	the	the	DT
cord-000372-wzwpyvll	581	6	leader	leader	NN
cord-000372-wzwpyvll	581	7	proteinase	proteinase	NN
cord-000372-wzwpyvll	581	8	of	of	IN
cord-000372-wzwpyvll	581	9	foot	foot	NN
cord-000372-wzwpyvll	581	10	-	-	HYPH
cord-000372-wzwpyvll	581	11	and	and	CC
cord-000372-wzwpyvll	581	12	-	-	HYPH
cord-000372-wzwpyvll	581	13	mouth	mouth	NN
cord-000372-wzwpyvll	581	14	disease	disease	NN
cord-000372-wzwpyvll	581	15	virus	virus	NN
cord-000372-wzwpyvll	581	16	is	be	VBZ
cord-000372-wzwpyvll	581	17	required	require	VBN
cord-000372-wzwpyvll	581	18	for	for	IN
cord-000372-wzwpyvll	581	19	proper	proper	JJ
cord-000372-wzwpyvll	581	20	subcellular	subcellular	JJ
cord-000372-wzwpyvll	581	21	localization	localization	NN
cord-000372-wzwpyvll	581	22	and	and	CC
cord-000372-wzwpyvll	581	23	function	function	NN
cord-000372-wzwpyvll	582	1	Differential	differential	JJ
cord-000372-wzwpyvll	582	2	IFNα	IFNα	NNP
cord-000372-wzwpyvll	582	3	/	/	SYM
cord-000372-wzwpyvll	582	4	β	β	NN
cord-000372-wzwpyvll	582	5	production	production	NN
cord-000372-wzwpyvll	582	6	suppressing	suppress	VBG
cord-000372-wzwpyvll	582	7	capacities	capacity	NNS
cord-000372-wzwpyvll	582	8	of	of	IN
cord-000372-wzwpyvll	582	9	the	the	DT
cord-000372-wzwpyvll	582	10	leader	leader	NN
cord-000372-wzwpyvll	582	11	proteins	protein	NNS
cord-000372-wzwpyvll	582	12	of	of	IN
cord-000372-wzwpyvll	582	13	mengovirus	mengovirus	NNP
cord-000372-wzwpyvll	582	14	and	and	CC
cord-000372-wzwpyvll	582	15	foot	foot	NN
cord-000372-wzwpyvll	582	16	-	-	HYPH
cord-000372-wzwpyvll	582	17	and	and	CC
cord-000372-wzwpyvll	582	18	-	-	HYPH
cord-000372-wzwpyvll	582	19	mouth	mouth	NN
cord-000372-wzwpyvll	582	20	disease	disease	NN
cord-000372-wzwpyvll	582	21	virus	virus	NN
cord-000372-wzwpyvll	582	22	Leader	Leader	NNP
cord-000372-wzwpyvll	582	23	protein	protein	NN
cord-000372-wzwpyvll	582	24	of	of	IN
cord-000372-wzwpyvll	582	25	foot	foot	NN
cord-000372-wzwpyvll	582	26	-	-	HYPH
cord-000372-wzwpyvll	582	27	and	and	CC
cord-000372-wzwpyvll	582	28	-	-	HYPH
cord-000372-wzwpyvll	582	29	mouth	mouth	NN
cord-000372-wzwpyvll	582	30	disease	disease	NN
cord-000372-wzwpyvll	582	31	virus	virus	NN
cord-000372-wzwpyvll	582	32	is	be	VBZ
cord-000372-wzwpyvll	582	33	required	require	VBN
cord-000372-wzwpyvll	582	34	for	for	IN
cord-000372-wzwpyvll	582	35	cleavage	cleavage	NN
cord-000372-wzwpyvll	582	36	of	of	IN
cord-000372-wzwpyvll	582	37	the	the	DT
cord-000372-wzwpyvll	582	38	p220	p220	NNP
cord-000372-wzwpyvll	582	39	component	component	NN
cord-000372-wzwpyvll	582	40	of	of	IN
cord-000372-wzwpyvll	582	41	the	the	DT
cord-000372-wzwpyvll	582	42	cap	cap	NN
cord-000372-wzwpyvll	582	43	-	-	HYPH
cord-000372-wzwpyvll	582	44	binding	bind	VBG
cord-000372-wzwpyvll	582	45	protein	protein	NN
cord-000372-wzwpyvll	582	46	complex	complex	NN
cord-000372-wzwpyvll	582	47	Relationship	relationship	NN
cord-000372-wzwpyvll	582	48	of	of	IN
cord-000372-wzwpyvll	582	49	p220	p220	NNP
cord-000372-wzwpyvll	582	50	cleavage	cleavage	NN
cord-000372-wzwpyvll	582	51	during	during	IN
cord-000372-wzwpyvll	582	52	picornavirus	picornavirus	JJ
cord-000372-wzwpyvll	582	53	infection	infection	NN
cord-000372-wzwpyvll	582	54	to	to	IN
cord-000372-wzwpyvll	582	55	2A	2a	NN
cord-000372-wzwpyvll	582	56	proteinase	proteinase	NN
cord-000372-wzwpyvll	582	57	sequencing	sequencing	NN
cord-000372-wzwpyvll	582	58	Extremely	extremely	RB
cord-000372-wzwpyvll	582	59	efficient	efficient	JJ
cord-000372-wzwpyvll	582	60	cleavage	cleavage	NN
cord-000372-wzwpyvll	582	61	of	of	IN
cord-000372-wzwpyvll	582	62	eIF4	eIF4	NNP
cord-000372-wzwpyvll	582	63	G	G	NNP
cord-000372-wzwpyvll	582	64	by	by	IN
cord-000372-wzwpyvll	582	65	picornaviral	picornaviral	NNP
cord-000372-wzwpyvll	582	66	proteinases	proteinases	NNP
cord-000372-wzwpyvll	582	67	L	L	NNP
cord-000372-wzwpyvll	582	68	and	and	CC
cord-000372-wzwpyvll	582	69	2A	2a	CD
cord-000372-wzwpyvll	583	1	in	in	IN
cord-000372-wzwpyvll	583	2	vitro	vitro	FW
cord-000372-wzwpyvll	583	3	Foot	Foot	NNP
cord-000372-wzwpyvll	583	4	-	-	HYPH
cord-000372-wzwpyvll	583	5	and	and	CC
cord-000372-wzwpyvll	583	6	-	-	HYPH
cord-000372-wzwpyvll	583	7	mouth	mouth	NN
cord-000372-wzwpyvll	583	8	disease	disease	NN
cord-000372-wzwpyvll	583	9	virus	virus	NN
cord-000372-wzwpyvll	584	1	2A	2A	NNP
cord-000372-wzwpyvll	584	2	oligopeptide	oligopeptide	NNP
cord-000372-wzwpyvll	584	3	mediated	mediate	VBN
cord-000372-wzwpyvll	584	4	cleavage	cleavage	NN
cord-000372-wzwpyvll	584	5	of	of	IN
cord-000372-wzwpyvll	584	6	an	an	DT
cord-000372-wzwpyvll	584	7	artificial	artificial	JJ
cord-000372-wzwpyvll	584	8	polyprotein	polyprotein	NNP
cord-000372-wzwpyvll	584	9	Analysis	Analysis	NNP
cord-000372-wzwpyvll	584	10	of	of	IN
cord-000372-wzwpyvll	584	11	the	the	DT
cord-000372-wzwpyvll	584	12	aphthovirus	aphthovirus	NNP
cord-000372-wzwpyvll	584	13	2A/2B	2a/2b	CD
cord-000372-wzwpyvll	584	14	polyprotein	polyprotein	NNP
cord-000372-wzwpyvll	584	15	'	'	``
cord-000372-wzwpyvll	584	16	cleavage	cleavage	NN
cord-000372-wzwpyvll	584	17	'	'	''
cord-000372-wzwpyvll	584	18	mechanism	mechanism	NN
cord-000372-wzwpyvll	584	19	indicates	indicate	VBZ
cord-000372-wzwpyvll	584	20	not	not	RB
cord-000372-wzwpyvll	584	21	a	a	DT
cord-000372-wzwpyvll	584	22	proteolytic	proteolytic	JJ
cord-000372-wzwpyvll	584	23	reaction	reaction	NN
cord-000372-wzwpyvll	584	24	,	,	,
cord-000372-wzwpyvll	584	25	but	but	CC
cord-000372-wzwpyvll	584	26	a	a	DT
cord-000372-wzwpyvll	584	27	novel	novel	JJ
cord-000372-wzwpyvll	584	28	translational	translational	JJ
cord-000372-wzwpyvll	584	29	effect	effect	NN
cord-000372-wzwpyvll	584	30	:	:	:
cord-000372-wzwpyvll	584	31	a	a	DT
cord-000372-wzwpyvll	584	32	putative	putative	JJ
cord-000372-wzwpyvll	584	33	ribosomal	ribosomal	NN
cord-000372-wzwpyvll	584	34	'	'	''
cord-000372-wzwpyvll	584	35	skip	skip	VB
cord-000372-wzwpyvll	584	36	The	the	DT
cord-000372-wzwpyvll	584	37	cleavage	cleavage	NN
cord-000372-wzwpyvll	584	38	activities	activity	NNS
cord-000372-wzwpyvll	584	39	of	of	IN
cord-000372-wzwpyvll	584	40	aphthovirus	aphthovirus	NNP
cord-000372-wzwpyvll	584	41	and	and	CC
cord-000372-wzwpyvll	584	42	cardiovirus	cardiovirus	NNP
cord-000372-wzwpyvll	584	43	2A	2a	CD
cord-000372-wzwpyvll	584	44	proteins	protein	NNS
cord-000372-wzwpyvll	584	45	Purification	Purification	NNP
cord-000372-wzwpyvll	584	46	and	and	CC
cord-000372-wzwpyvll	584	47	partial	partial	JJ
cord-000372-wzwpyvll	584	48	characterization	characterization	NN
cord-000372-wzwpyvll	584	49	of	of	IN
cord-000372-wzwpyvll	584	50	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	584	51	protease	protease	NN
cord-000372-wzwpyvll	584	52	2A	2a	CD
cord-000372-wzwpyvll	584	53	by	by	IN
cord-000372-wzwpyvll	584	54	means	mean	NNS
cord-000372-wzwpyvll	584	55	of	of	IN
cord-000372-wzwpyvll	584	56	a	a	DT
cord-000372-wzwpyvll	584	57	functional	functional	JJ
cord-000372-wzwpyvll	584	58	assay	assay	NN
cord-000372-wzwpyvll	584	59	Poliovirus	Poliovirus	NNP
cord-000372-wzwpyvll	584	60	proteinase	proteinase	NN
cord-000372-wzwpyvll	584	61	3C	3c	NN
cord-000372-wzwpyvll	584	62	:	:	:
cord-000372-wzwpyvll	584	63	large	large	JJ
cord-000372-wzwpyvll	584	64	-	-	HYPH
cord-000372-wzwpyvll	584	65	scale	scale	NN
cord-000372-wzwpyvll	584	66	expression	expression	NN
cord-000372-wzwpyvll	584	67	,	,	,
cord-000372-wzwpyvll	584	68	purification	purification	NN
cord-000372-wzwpyvll	584	69	,	,	,
cord-000372-wzwpyvll	584	70	and	and	CC
cord-000372-wzwpyvll	584	71	specific	specific	JJ
cord-000372-wzwpyvll	584	72	cleavage	cleavage	NN
cord-000372-wzwpyvll	584	73	activity	activity	NN
cord-000372-wzwpyvll	584	74	on	on	IN
cord-000372-wzwpyvll	584	75	natural	natural	JJ
cord-000372-wzwpyvll	584	76	and	and	CC
cord-000372-wzwpyvll	584	77	synthetic	synthetic	JJ
cord-000372-wzwpyvll	584	78	substrates	substrate	NNS
cord-000372-wzwpyvll	584	79	in	in	IN
cord-000372-wzwpyvll	584	80	vitro	vitro	FW
cord-000372-wzwpyvll	584	81	Multiple	multiple	JJ
cord-000372-wzwpyvll	584	82	proteases	protease	NNS
cord-000372-wzwpyvll	584	83	in	in	IN
cord-000372-wzwpyvll	584	84	foot	foot	NN
cord-000372-wzwpyvll	584	85	-	-	HYPH
cord-000372-wzwpyvll	584	86	and	and	CC
cord-000372-wzwpyvll	584	87	-	-	HYPH
cord-000372-wzwpyvll	584	88	mouth	mouth	NN
cord-000372-wzwpyvll	584	89	disease	disease	NN
cord-000372-wzwpyvll	584	90	virus	virus	NN
cord-000372-wzwpyvll	584	91	replication	replication	NN
cord-000372-wzwpyvll	584	92	Antiviral	antiviral	JJ
cord-000372-wzwpyvll	584	93	effects	effect	NNS
cord-000372-wzwpyvll	584	94	of	of	IN
cord-000372-wzwpyvll	584	95	a	a	DT
cord-000372-wzwpyvll	584	96	thiol	thiol	NN
cord-000372-wzwpyvll	584	97	protease	protease	NN
cord-000372-wzwpyvll	584	98	inhibitor	inhibitor	NN
cord-000372-wzwpyvll	584	99	on	on	IN
cord-000372-wzwpyvll	584	100	foot	foot	NN
cord-000372-wzwpyvll	584	101	-	-	HYPH
cord-000372-wzwpyvll	584	102	and	and	CC
cord-000372-wzwpyvll	584	103	-	-	HYPH
cord-000372-wzwpyvll	584	104	mouth	mouth	NN
cord-000372-wzwpyvll	584	105	disease	disease	NN
cord-000372-wzwpyvll	584	106	virus	virus	NN
cord-000372-wzwpyvll	584	107	Putative	Putative	NNP
cord-000372-wzwpyvll	584	108	papain	papain	NN
cord-000372-wzwpyvll	584	109	-	-	HYPH
cord-000372-wzwpyvll	584	110	related	relate	VBN
cord-000372-wzwpyvll	584	111	thiol	thiol	NN
cord-000372-wzwpyvll	584	112	proteases	protease	NNS
cord-000372-wzwpyvll	584	113	of	of	IN
cord-000372-wzwpyvll	584	114	positive	positive	JJ
cord-000372-wzwpyvll	584	115	-	-	HYPH
cord-000372-wzwpyvll	584	116	strand	strand	NN
cord-000372-wzwpyvll	584	117	RNA	RNA	NNP
cord-000372-wzwpyvll	584	118	viruses	virus	NNS
cord-000372-wzwpyvll	584	119	.	.	.
cord-000372-wzwpyvll	585	1	Identification	identification	NN
cord-000372-wzwpyvll	585	2	of	of	IN
cord-000372-wzwpyvll	585	3	rubi	rubi	NNP
cord-000372-wzwpyvll	585	4	-	-	HYPH
cord-000372-wzwpyvll	585	5	and	and	CC
cord-000372-wzwpyvll	585	6	aphthovirus	aphthovirus	NNP
cord-000372-wzwpyvll	585	7	proteases	protease	NNS
cord-000372-wzwpyvll	585	8	and	and	CC
cord-000372-wzwpyvll	585	9	delineation	delineation	NN
cord-000372-wzwpyvll	585	10	of	of	IN
cord-000372-wzwpyvll	585	11	a	a	DT
cord-000372-wzwpyvll	585	12	novel	novel	JJ
cord-000372-wzwpyvll	585	13	conserved	conserve	VBN
cord-000372-wzwpyvll	585	14	domain	domain	NN
cord-000372-wzwpyvll	585	15	associated	associate	VBN
cord-000372-wzwpyvll	585	16	with	with	IN
cord-000372-wzwpyvll	585	17	proteases	protease	NNS
cord-000372-wzwpyvll	585	18	of	of	IN
cord-000372-wzwpyvll	585	19	rubi	rubi	NNP
cord-000372-wzwpyvll	585	20	,	,	,
cord-000372-wzwpyvll	585	21	α	α	NN
cord-000372-wzwpyvll	585	22	-	-	HYPH
cord-000372-wzwpyvll	585	23	and	and	CC
cord-000372-wzwpyvll	585	24	coronaviruses	coronaviruse	NNS
cord-000372-wzwpyvll	585	25	Identification	Identification	NNP
cord-000372-wzwpyvll	585	26	of	of	IN
cord-000372-wzwpyvll	585	27	the	the	DT
cord-000372-wzwpyvll	585	28	active	active	JJ
cord-000372-wzwpyvll	585	29	-	-	HYPH
cord-000372-wzwpyvll	585	30	site	site	NN
cord-000372-wzwpyvll	585	31	residues	residue	NNS
cord-000372-wzwpyvll	585	32	of	of	IN
cord-000372-wzwpyvll	585	33	the	the	DT
cord-000372-wzwpyvll	585	34	L	L	NNP
cord-000372-wzwpyvll	585	35	proteinase	proteinase	NN
cord-000372-wzwpyvll	585	36	of	of	IN
cord-000372-wzwpyvll	585	37	foot	foot	NN
cord-000372-wzwpyvll	585	38	-	-	HYPH
cord-000372-wzwpyvll	585	39	and	and	CC
cord-000372-wzwpyvll	585	40	-	-	HYPH
cord-000372-wzwpyvll	585	41	mouth	mouth	NN
cord-000372-wzwpyvll	585	42	disease	disease	NN
cord-000372-wzwpyvll	585	43	virus	virus	NN
cord-000372-wzwpyvll	585	44	Identification	identification	NN
cord-000372-wzwpyvll	585	45	of	of	IN
cord-000372-wzwpyvll	585	46	critical	critical	JJ
cord-000372-wzwpyvll	585	47	amino	amino	NN
cord-000372-wzwpyvll	585	48	acids	acid	NNS
cord-000372-wzwpyvll	585	49	within	within	IN
cord-000372-wzwpyvll	585	50	the	the	DT
cord-000372-wzwpyvll	585	51	foot	foot	NN
cord-000372-wzwpyvll	585	52	-	-	HYPH
cord-000372-wzwpyvll	585	53	and	and	CC
cord-000372-wzwpyvll	585	54	-	-	HYPH
cord-000372-wzwpyvll	585	55	mouth	mouth	NN
cord-000372-wzwpyvll	585	56	disease	disease	NN
cord-000372-wzwpyvll	585	57	virus	virus	NN
cord-000372-wzwpyvll	585	58	leader	leader	NN
cord-000372-wzwpyvll	585	59	protein	protein	NN
cord-000372-wzwpyvll	585	60	,	,	,
cord-000372-wzwpyvll	585	61	a	a	DT
cord-000372-wzwpyvll	585	62	cysteine	cysteine	NN
cord-000372-wzwpyvll	585	63	protease	protease	NN
cord-000372-wzwpyvll	585	64	Structural	structural	JJ
cord-000372-wzwpyvll	585	65	similarity	similarity	NN
cord-000372-wzwpyvll	585	66	of	of	IN
cord-000372-wzwpyvll	585	67	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	585	68	cysteine	cysteine	NN
cord-000372-wzwpyvll	585	69	proteinase	proteinase	NN
cord-000372-wzwpyvll	585	70	P3	P3	NNP
cord-000372-wzwpyvll	585	71	-	-	HYPH
cord-000372-wzwpyvll	585	72	7c	7c	NNP
cord-000372-wzwpyvll	585	73	and	and	CC
cord-000372-wzwpyvll	585	74	cellular	cellular	JJ
cord-000372-wzwpyvll	585	75	serine	serine	NN
cord-000372-wzwpyvll	585	76	proteinase	proteinase	NN
cord-000372-wzwpyvll	585	77	of	of	IN
cord-000372-wzwpyvll	585	78	trypsin	trypsin	NN
cord-000372-wzwpyvll	585	79	Cysteine	cysteine	NN
cord-000372-wzwpyvll	585	80	proteases	protease	NNS
cord-000372-wzwpyvll	585	81	of	of	IN
cord-000372-wzwpyvll	585	82	positive	positive	JJ
cord-000372-wzwpyvll	585	83	strand	strand	NN
cord-000372-wzwpyvll	585	84	RNA	RNA	NNP
cord-000372-wzwpyvll	585	85	viruses	virus	NNS
cord-000372-wzwpyvll	585	86	and	and	CC
cord-000372-wzwpyvll	585	87	chymotrypsin	chymotrypsin	NNP
cord-000372-wzwpyvll	585	88	-	-	HYPH
cord-000372-wzwpyvll	585	89	like	like	JJ
cord-000372-wzwpyvll	585	90	serin	serin	NNP
cord-000372-wzwpyvll	585	91	proteases	protease	NNS
cord-000372-wzwpyvll	585	92	:	:	:
cord-000372-wzwpyvll	585	93	a	a	DT
cord-000372-wzwpyvll	585	94	distinct	distinct	JJ
cord-000372-wzwpyvll	585	95	protein	protein	NN
cord-000372-wzwpyvll	585	96	superfamily	superfamily	NN
cord-000372-wzwpyvll	585	97	with	with	IN
cord-000372-wzwpyvll	585	98	a	a	DT
cord-000372-wzwpyvll	585	99	common	common	JJ
cord-000372-wzwpyvll	585	100	structural	structural	NN
cord-000372-wzwpyvll	585	101	fold	fold	NN
cord-000372-wzwpyvll	585	102	Viral	viral	JJ
cord-000372-wzwpyvll	585	103	cysteine	cysteine	NN
cord-000372-wzwpyvll	585	104	proteases	protease	NNS
cord-000372-wzwpyvll	585	105	are	be	VBP
cord-000372-wzwpyvll	585	106	homologous	homologous	JJ
cord-000372-wzwpyvll	585	107	to	to	IN
cord-000372-wzwpyvll	585	108	the	the	DT
cord-000372-wzwpyvll	585	109	trypsin	trypsin	NN
cord-000372-wzwpyvll	585	110	-	-	HYPH
cord-000372-wzwpyvll	585	111	like	like	JJ
cord-000372-wzwpyvll	585	112	family	family	NN
cord-000372-wzwpyvll	585	113	of	of	IN
cord-000372-wzwpyvll	585	114	serine	serine	NN
cord-000372-wzwpyvll	585	115	proteases	protease	NNS
cord-000372-wzwpyvll	585	116	:	:	:
cord-000372-wzwpyvll	585	117	structural	structural	JJ
cord-000372-wzwpyvll	585	118	and	and	CC
cord-000372-wzwpyvll	585	119	functional	functional	JJ
cord-000372-wzwpyvll	585	120	implications	implication	NNS
cord-000372-wzwpyvll	586	1	A	a	DT
cord-000372-wzwpyvll	586	2	second	second	JJ
cord-000372-wzwpyvll	586	3	virus	virus	NN
cord-000372-wzwpyvll	586	4	-	-	HYPH
cord-000372-wzwpyvll	586	5	encoded	encode	VBN
cord-000372-wzwpyvll	586	6	proteinase	proteinase	NN
cord-000372-wzwpyvll	586	7	involved	involve	VBN
cord-000372-wzwpyvll	586	8	in	in	IN
cord-000372-wzwpyvll	586	9	proteolytic	proteolytic	JJ
cord-000372-wzwpyvll	586	10	processing	processing	NN
cord-000372-wzwpyvll	586	11	of	of	IN
cord-000372-wzwpyvll	586	12	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	586	13	polyprotein	polyprotein	NN
cord-000372-wzwpyvll	586	14	Substrate	Substrate	NNP
cord-000372-wzwpyvll	586	15	requirements	requirement	NNS
cord-000372-wzwpyvll	586	16	of	of	IN
cord-000372-wzwpyvll	586	17	a	a	DT
cord-000372-wzwpyvll	586	18	human	human	JJ
cord-000372-wzwpyvll	586	19	rhinoviral	rhinoviral	NN
cord-000372-wzwpyvll	586	20	2A	2a	CD
cord-000372-wzwpyvll	586	21	proteinase	proteinase	NN
cord-000372-wzwpyvll	586	22	Determinants	determinant	NNS
cord-000372-wzwpyvll	586	23	of	of	IN
cord-000372-wzwpyvll	586	24	substrate	substrate	NN
cord-000372-wzwpyvll	586	25	recognition	recognition	NN
cord-000372-wzwpyvll	586	26	by	by	IN
cord-000372-wzwpyvll	586	27	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	586	28	2A	2a	CD
cord-000372-wzwpyvll	586	29	proteinase	proteinase	NN
cord-000372-wzwpyvll	586	30	Cleavage	cleavage	NN
cord-000372-wzwpyvll	586	31	specificity	specificity	NN
cord-000372-wzwpyvll	586	32	on	on	IN
cord-000372-wzwpyvll	586	33	synthetic	synthetic	JJ
cord-000372-wzwpyvll	586	34	peptide	peptide	JJ
cord-000372-wzwpyvll	586	35	substrates	substrate	NNS
cord-000372-wzwpyvll	586	36	of	of	IN
cord-000372-wzwpyvll	586	37	human	human	JJ
cord-000372-wzwpyvll	586	38	rhinovirus	rhinovirus	NN
cord-000372-wzwpyvll	586	39	2	2	CD
cord-000372-wzwpyvll	586	40	proteinase	proteinase	NN
cord-000372-wzwpyvll	586	41	2A	2a	CD
cord-000372-wzwpyvll	586	42	Genetic	genetic	JJ
cord-000372-wzwpyvll	586	43	selection	selection	NN
cord-000372-wzwpyvll	586	44	of	of	IN
cord-000372-wzwpyvll	586	45	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	586	46	2A(pro)-binding	2a(pro)-binde	VBG
cord-000372-wzwpyvll	586	47	peptides	peptide	NNS
cord-000372-wzwpyvll	586	48	Identification	Identification	NNP
cord-000372-wzwpyvll	586	49	of	of	IN
cord-000372-wzwpyvll	586	50	essential	essential	JJ
cord-000372-wzwpyvll	586	51	amino	amino	NN
cord-000372-wzwpyvll	586	52	acid	acid	NN
cord-000372-wzwpyvll	586	53	residues	residue	NNS
cord-000372-wzwpyvll	586	54	in	in	IN
cord-000372-wzwpyvll	586	55	the	the	DT
cord-000372-wzwpyvll	586	56	functional	functional	JJ
cord-000372-wzwpyvll	586	57	activity	activity	NN
cord-000372-wzwpyvll	586	58	of	of	IN
cord-000372-wzwpyvll	586	59	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	587	1	2A	2a	CD
cord-000372-wzwpyvll	587	2	protease	protease	NN
cord-000372-wzwpyvll	587	3	Mutational	Mutational	NNP
cord-000372-wzwpyvll	587	4	analyses	analysis	NNS
cord-000372-wzwpyvll	587	5	support	support	VBP
cord-000372-wzwpyvll	587	6	a	a	DT
cord-000372-wzwpyvll	587	7	model	model	NN
cord-000372-wzwpyvll	587	8	for	for	IN
cord-000372-wzwpyvll	587	9	the	the	DT
cord-000372-wzwpyvll	587	10	HRV2	HRV2	NNP
cord-000372-wzwpyvll	587	11	2A	2a	NN
cord-000372-wzwpyvll	587	12	proteinase	proteinase	NN
cord-000372-wzwpyvll	588	1	The	the	DT
cord-000372-wzwpyvll	588	2	structure	structure	NN
cord-000372-wzwpyvll	588	3	of	of	IN
cord-000372-wzwpyvll	588	4	the	the	DT
cord-000372-wzwpyvll	588	5	2A	2a	CD
cord-000372-wzwpyvll	588	6	proteinase	proteinase	NN
cord-000372-wzwpyvll	588	7	from	from	IN
cord-000372-wzwpyvll	588	8	a	a	DT
cord-000372-wzwpyvll	588	9	common	common	JJ
cord-000372-wzwpyvll	588	10	cold	cold	JJ
cord-000372-wzwpyvll	588	11	virus	virus	NN
cord-000372-wzwpyvll	588	12	:	:	:
cord-000372-wzwpyvll	588	13	a	a	DT
cord-000372-wzwpyvll	588	14	proteinase	proteinase	NN
cord-000372-wzwpyvll	588	15	responsible	responsible	JJ
cord-000372-wzwpyvll	588	16	for	for	IN
cord-000372-wzwpyvll	588	17	the	the	DT
cord-000372-wzwpyvll	588	18	shut	shut	NN
cord-000372-wzwpyvll	588	19	-	-	HYPH
cord-000372-wzwpyvll	588	20	off	off	NN
cord-000372-wzwpyvll	588	21	of	of	IN
cord-000372-wzwpyvll	588	22	host	host	NN
cord-000372-wzwpyvll	588	23	-	-	HYPH
cord-000372-wzwpyvll	588	24	cell	cell	NN
cord-000372-wzwpyvll	588	25	protein	protein	NN
cord-000372-wzwpyvll	588	26	synthesis	synthesis	NN
cord-000372-wzwpyvll	588	27	Characterization	characterization	NN
cord-000372-wzwpyvll	588	28	of	of	IN
cord-000372-wzwpyvll	588	29	the	the	DT
cord-000372-wzwpyvll	588	30	roles	role	NNS
cord-000372-wzwpyvll	588	31	of	of	IN
cord-000372-wzwpyvll	588	32	conserved	conserved	JJ
cord-000372-wzwpyvll	588	33	cysteine	cysteine	NN
cord-000372-wzwpyvll	588	34	and	and	CC
cord-000372-wzwpyvll	588	35	histidine	histidine	NN
cord-000372-wzwpyvll	588	36	residues	residue	NNS
cord-000372-wzwpyvll	588	37	in	in	IN
cord-000372-wzwpyvll	588	38	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	588	39	2A	2a	CD
cord-000372-wzwpyvll	588	40	protease	protease	NN
cord-000372-wzwpyvll	589	1	The	the	DT
cord-000372-wzwpyvll	589	2	2A	2a	CD
cord-000372-wzwpyvll	589	3	proteinase	proteinase	NN
cord-000372-wzwpyvll	589	4	of	of	IN
cord-000372-wzwpyvll	589	5	human	human	JJ
cord-000372-wzwpyvll	589	6	rhinovirus	rhinovirus	NN
cord-000372-wzwpyvll	589	7	is	be	VBZ
cord-000372-wzwpyvll	589	8	a	a	DT
cord-000372-wzwpyvll	589	9	zinc	zinc	NN
cord-000372-wzwpyvll	589	10	containing	contain	VBG
cord-000372-wzwpyvll	589	11	enzyme	enzyme	NN
cord-000372-wzwpyvll	589	12	Spectroscopic	spectroscopic	JJ
cord-000372-wzwpyvll	589	13	characterization	characterization	NN
cord-000372-wzwpyvll	589	14	of	of	IN
cord-000372-wzwpyvll	589	15	rhinoviral	rhinoviral	JJ
cord-000372-wzwpyvll	589	16	protease	protease	NN
cord-000372-wzwpyvll	589	17	2A	2a	CD
cord-000372-wzwpyvll	589	18	:	:	:
cord-000372-wzwpyvll	590	1	Zn	Zn	NNP
cord-000372-wzwpyvll	590	2	is	be	VBZ
cord-000372-wzwpyvll	590	3	essential	essential	JJ
cord-000372-wzwpyvll	590	4	for	for	IN
cord-000372-wzwpyvll	590	5	the	the	DT
cord-000372-wzwpyvll	590	6	structural	structural	JJ
cord-000372-wzwpyvll	590	7	integrity	integrity	NN
cord-000372-wzwpyvll	590	8	The	the	DT
cord-000372-wzwpyvll	590	9	yeast	yeast	NN
cord-000372-wzwpyvll	590	10	Saccharomyces	saccharomyce	NNS
cord-000372-wzwpyvll	590	11	cerevisiae	cerevisiae	NNS
cord-000372-wzwpyvll	590	12	as	as	IN
cord-000372-wzwpyvll	590	13	a	a	DT
cord-000372-wzwpyvll	590	14	genetic	genetic	JJ
cord-000372-wzwpyvll	590	15	system	system	NN
cord-000372-wzwpyvll	590	16	for	for	IN
cord-000372-wzwpyvll	590	17	obtaining	obtain	VBG
cord-000372-wzwpyvll	590	18	variants	variant	NNS
cord-000372-wzwpyvll	590	19	of	of	IN
cord-000372-wzwpyvll	590	20	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	590	21	protease	protease	NN
cord-000372-wzwpyvll	590	22	2A	2a	CD
cord-000372-wzwpyvll	590	23	Mutational	Mutational	NNP
cord-000372-wzwpyvll	590	24	analysis	analysis	NN
cord-000372-wzwpyvll	590	25	of	of	IN
cord-000372-wzwpyvll	590	26	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	590	27	2A(pro	2a(pro	CD
cord-000372-wzwpyvll	590	28	)	)	-RRB-
cord-000372-wzwpyvll	590	29	:	:	:
cord-000372-wzwpyvll	590	30	distinct	distinct	JJ
cord-000372-wzwpyvll	590	31	inhibitory	inhibitory	JJ
cord-000372-wzwpyvll	590	32	functions	function	NNS
cord-000372-wzwpyvll	590	33	of	of	IN
cord-000372-wzwpyvll	590	34	2A(pro	2a(pro	CD
cord-000372-wzwpyvll	590	35	)	)	-RRB-
cord-000372-wzwpyvll	591	1	on	on	IN
cord-000372-wzwpyvll	591	2	translation	translation	NN
cord-000372-wzwpyvll	591	3	and	and	CC
cord-000372-wzwpyvll	591	4	transcription	transcription	NN
cord-000372-wzwpyvll	591	5	Defective	Defective	NNP
cord-000372-wzwpyvll	591	6	RNA	RNA	NNP
cord-000372-wzwpyvll	591	7	replication	replication	NN
cord-000372-wzwpyvll	591	8	by	by	IN
cord-000372-wzwpyvll	591	9	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	591	10	mutants	mutant	NNS
cord-000372-wzwpyvll	591	11	deficient	deficient	JJ
cord-000372-wzwpyvll	591	12	in	in	IN
cord-000372-wzwpyvll	591	13	2A	2a	CD
cord-000372-wzwpyvll	591	14	protease	protease	NN
cord-000372-wzwpyvll	591	15	cleavage	cleavage	NN
cord-000372-wzwpyvll	591	16	activity	activity	NN
cord-000372-wzwpyvll	592	1	2A	2A	NNP
cord-000372-wzwpyvll	592	2	protease	protease	NN
cord-000372-wzwpyvll	592	3	is	be	VBZ
cord-000372-wzwpyvll	592	4	not	not	RB
cord-000372-wzwpyvll	592	5	a	a	DT
cord-000372-wzwpyvll	592	6	prerequisite	prerequisite	NN
cord-000372-wzwpyvll	592	7	for	for	IN
cord-000372-wzwpyvll	592	8	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	592	9	replication	replication	NN
cord-000372-wzwpyvll	592	10	Proteinase	Proteinase	NNP
cord-000372-wzwpyvll	592	11	2A	2a	NN
cord-000372-wzwpyvll	592	12	is	be	VBZ
cord-000372-wzwpyvll	592	13	essential	essential	JJ
cord-000372-wzwpyvll	592	14	for	for	IN
cord-000372-wzwpyvll	592	15	enterovirus	enterovirus	NN
cord-000372-wzwpyvll	592	16	replication	replication	NN
cord-000372-wzwpyvll	592	17	in	in	IN
cord-000372-wzwpyvll	592	18	type	type	NN
cord-000372-wzwpyvll	592	19	I	-PRON-	PRP
cord-000372-wzwpyvll	592	20	interferontreated	interferontreate	VBD
cord-000372-wzwpyvll	592	21	cells	cell	NNS
cord-000372-wzwpyvll	592	22	Viable	viable	JJ
cord-000372-wzwpyvll	592	23	polioviruses	poliovirus	NNS
cord-000372-wzwpyvll	592	24	that	that	WDT
cord-000372-wzwpyvll	592	25	encode	encode	VBP
cord-000372-wzwpyvll	592	26	2A	2a	CD
cord-000372-wzwpyvll	592	27	proteins	protein	NNS
cord-000372-wzwpyvll	592	28	with	with	IN
cord-000372-wzwpyvll	592	29	fluorescent	fluorescent	JJ
cord-000372-wzwpyvll	592	30	protein	protein	NN
cord-000372-wzwpyvll	592	31	tags	tags	NNP
cord-000372-wzwpyvll	592	32	Regulation	Regulation	NNP
cord-000372-wzwpyvll	592	33	of	of	IN
cord-000372-wzwpyvll	592	34	translation	translation	NN
cord-000372-wzwpyvll	592	35	initiation	initiation	NN
cord-000372-wzwpyvll	592	36	in	in	IN
cord-000372-wzwpyvll	592	37	eukaryotes	eukaryote	NNS
cord-000372-wzwpyvll	592	38	:	:	:
cord-000372-wzwpyvll	592	39	mechanisms	mechanism	NNS
cord-000372-wzwpyvll	592	40	and	and	CC
cord-000372-wzwpyvll	592	41	biological	biological	JJ
cord-000372-wzwpyvll	592	42	targets	target	NNS
cord-000372-wzwpyvll	593	1	The	the	DT
cord-000372-wzwpyvll	593	2	mechanism	mechanism	NN
cord-000372-wzwpyvll	593	3	of	of	IN
cord-000372-wzwpyvll	593	4	eukaryotic	eukaryotic	JJ
cord-000372-wzwpyvll	593	5	translation	translation	NN
cord-000372-wzwpyvll	593	6	initiation	initiation	NN
cord-000372-wzwpyvll	593	7	and	and	CC
cord-000372-wzwpyvll	593	8	principles	principle	NNS
cord-000372-wzwpyvll	593	9	of	of	IN
cord-000372-wzwpyvll	593	10	its	-PRON-	PRP$
cord-000372-wzwpyvll	593	11	regulation	regulation	NN
cord-000372-wzwpyvll	594	1	eIF4	eif4	IN
cord-000372-wzwpyvll	594	2	initiation	initiation	NN
cord-000372-wzwpyvll	594	3	factors	factor	NNS
cord-000372-wzwpyvll	594	4	:	:	:
cord-000372-wzwpyvll	594	5	effectors	effector	NNS
cord-000372-wzwpyvll	594	6	of	of	IN
cord-000372-wzwpyvll	594	7	mRNA	mRNA	NNP
cord-000372-wzwpyvll	594	8	recruitment	recruitment	NN
cord-000372-wzwpyvll	594	9	to	to	IN
cord-000372-wzwpyvll	594	10	ribosomes	ribosome	NNS
cord-000372-wzwpyvll	594	11	and	and	CC
cord-000372-wzwpyvll	594	12	regulators	regulator	NNS
cord-000372-wzwpyvll	594	13	of	of	IN
cord-000372-wzwpyvll	594	14	translation	translation	NN
cord-000372-wzwpyvll	594	15	Molecular	molecular	JJ
cord-000372-wzwpyvll	594	16	mechanisms	mechanism	NNS
cord-000372-wzwpyvll	594	17	of	of	IN
cord-000372-wzwpyvll	594	18	translational	translational	JJ
cord-000372-wzwpyvll	594	19	control	control	NN
cord-000372-wzwpyvll	594	20	eIF4	eif4	IN
cord-000372-wzwpyvll	594	21	G	g	NN
cord-000372-wzwpyvll	594	22	:	:	:
cord-000372-wzwpyvll	594	23	a	a	DT
cord-000372-wzwpyvll	594	24	multipurpose	multipurpose	JJ
cord-000372-wzwpyvll	594	25	ribosome	ribosome	NN
cord-000372-wzwpyvll	594	26	adapter	adapter	NN
cord-000372-wzwpyvll	594	27	elF4	elF4	NNP
cord-000372-wzwpyvll	594	28	G	G	NNP
cord-000372-wzwpyvll	594	29	:	:	:
cord-000372-wzwpyvll	594	30	translation	translation	NN
cord-000372-wzwpyvll	594	31	's	's	POS
cord-000372-wzwpyvll	594	32	mystery	mystery	NN
cord-000372-wzwpyvll	594	33	factor	factor	NN
cord-000372-wzwpyvll	594	34	begins	begin	VBZ
cord-000372-wzwpyvll	594	35	to	to	TO
cord-000372-wzwpyvll	594	36	yield	yield	VB
cord-000372-wzwpyvll	594	37	its	-PRON-	PRP$
cord-000372-wzwpyvll	594	38	secrets	secret	NNS
cord-000372-wzwpyvll	594	39	Human	human	JJ
cord-000372-wzwpyvll	594	40	eukaryotic	eukaryotic	JJ
cord-000372-wzwpyvll	594	41	translation	translation	NN
cord-000372-wzwpyvll	594	42	initiation	initiation	NN
cord-000372-wzwpyvll	594	43	factor	factor	NN
cord-000372-wzwpyvll	594	44	4	4	CD
cord-000372-wzwpyvll	594	45	G	g	NN
cord-000372-wzwpyvll	594	46	(	(	-LRB-
cord-000372-wzwpyvll	594	47	eIF4	eIF4	NNP
cord-000372-wzwpyvll	594	48	G	G	NNP
cord-000372-wzwpyvll	594	49	)	)	-RRB-
cord-000372-wzwpyvll	594	50	possesses	possess	VBZ
cord-000372-wzwpyvll	594	51	two	two	CD
cord-000372-wzwpyvll	594	52	separate	separate	JJ
cord-000372-wzwpyvll	594	53	and	and	CC
cord-000372-wzwpyvll	594	54	independent	independent	JJ
cord-000372-wzwpyvll	594	55	binding	binding	NN
cord-000372-wzwpyvll	594	56	sites	site	NNS
cord-000372-wzwpyvll	594	57	for	for	IN
cord-000372-wzwpyvll	594	58	eIF4A	eIF4A	NNS
cord-000372-wzwpyvll	594	59	A	a	DT
cord-000372-wzwpyvll	594	60	newly	newly	RB
cord-000372-wzwpyvll	594	61	identified	identify	VBN
cord-000372-wzwpyvll	594	62	N	n	CD
cord-000372-wzwpyvll	594	63	-	-	HYPH
cord-000372-wzwpyvll	594	64	terminal	terminal	NN
cord-000372-wzwpyvll	594	65	amino	amino	NN
cord-000372-wzwpyvll	594	66	acid	acid	NN
cord-000372-wzwpyvll	594	67	sequence	sequence	NN
cord-000372-wzwpyvll	594	68	of	of	IN
cord-000372-wzwpyvll	594	69	human	human	NN
cord-000372-wzwpyvll	594	70	eIF4	eif4	IN
cord-000372-wzwpyvll	594	71	G	g	NN
cord-000372-wzwpyvll	595	1	binds	bind	VBZ
cord-000372-wzwpyvll	595	2	poly(A)-binding	poly(a)-binde	VBG
cord-000372-wzwpyvll	595	3	protein	protein	NN
cord-000372-wzwpyvll	595	4	and	and	CC
cord-000372-wzwpyvll	595	5	functions	function	NNS
cord-000372-wzwpyvll	595	6	in	in	IN
cord-000372-wzwpyvll	595	7	poly(A)-dependent	poly(a)-dependent	CD
cord-000372-wzwpyvll	595	8	translation	translation	NN
cord-000372-wzwpyvll	595	9	Circularization	Circularization	NNP
cord-000372-wzwpyvll	595	10	of	of	IN
cord-000372-wzwpyvll	595	11	mRNA	mRNA	NNP
cord-000372-wzwpyvll	595	12	by	by	IN
cord-000372-wzwpyvll	595	13	eukaryotic	eukaryotic	JJ
cord-000372-wzwpyvll	595	14	translation	translation	NN
cord-000372-wzwpyvll	595	15	initiation	initiation	NN
cord-000372-wzwpyvll	595	16	factors	factor	VBZ
cord-000372-wzwpyvll	595	17	MNK1	mnk1	RB
cord-000372-wzwpyvll	595	18	,	,	,
cord-000372-wzwpyvll	596	1	a	a	DT
cord-000372-wzwpyvll	596	2	new	new	JJ
cord-000372-wzwpyvll	596	3	MAP	MAP	NNP
cord-000372-wzwpyvll	596	4	kinaseactivated	kinaseactivated	JJ
cord-000372-wzwpyvll	596	5	protein	protein	NN
cord-000372-wzwpyvll	596	6	kinase	kinase	NN
cord-000372-wzwpyvll	596	7	,	,	,
cord-000372-wzwpyvll	596	8	isolated	isolate	VBN
cord-000372-wzwpyvll	596	9	by	by	IN
cord-000372-wzwpyvll	596	10	a	a	DT
cord-000372-wzwpyvll	596	11	novel	novel	JJ
cord-000372-wzwpyvll	596	12	expression	expression	NN
cord-000372-wzwpyvll	596	13	screening	screening	NN
cord-000372-wzwpyvll	596	14	method	method	NN
cord-000372-wzwpyvll	596	15	for	for	IN
cord-000372-wzwpyvll	596	16	identifying	identify	VBG
cord-000372-wzwpyvll	596	17	protein	protein	NN
cord-000372-wzwpyvll	596	18	kinase	kinase	NN
cord-000372-wzwpyvll	596	19	substrates	substrate	NNS
cord-000372-wzwpyvll	597	1	Mitogen	Mitogen	NNP
cord-000372-wzwpyvll	597	2	-	-	HYPH
cord-000372-wzwpyvll	597	3	activated	activate	VBN
cord-000372-wzwpyvll	597	4	protein	protein	NN
cord-000372-wzwpyvll	597	5	kinases	kinase	NNS
cord-000372-wzwpyvll	597	6	activate	activate	VBP
cord-000372-wzwpyvll	597	7	the	the	DT
cord-000372-wzwpyvll	597	8	serine	serine	NN
cord-000372-wzwpyvll	597	9	/	/	SYM
cord-000372-wzwpyvll	597	10	threonine	threonine	NN
cord-000372-wzwpyvll	597	11	kinases	kinase	NNS
cord-000372-wzwpyvll	597	12	Mnk1	Mnk1	NNP
cord-000372-wzwpyvll	597	13	and	and	CC
cord-000372-wzwpyvll	597	14	Mnk2	Mnk2	NNP
cord-000372-wzwpyvll	597	15	Human	Human	NNP
cord-000372-wzwpyvll	597	16	eukaryotic	eukaryotic	JJ
cord-000372-wzwpyvll	597	17	translation	translation	NN
cord-000372-wzwpyvll	597	18	initiation	initiation	NN
cord-000372-wzwpyvll	597	19	factor	factor	NN
cord-000372-wzwpyvll	597	20	4	4	CD
cord-000372-wzwpyvll	597	21	G	g	NN
cord-000372-wzwpyvll	597	22	(	(	-LRB-
cord-000372-wzwpyvll	597	23	eIF4	eIF4	NNP
cord-000372-wzwpyvll	597	24	G	G	NNP
cord-000372-wzwpyvll	597	25	)	)	-RRB-
cord-000372-wzwpyvll	597	26	recruits	recruit	VBZ
cord-000372-wzwpyvll	597	27	Mnk1	Mnk1	NNP
cord-000372-wzwpyvll	597	28	to	to	TO
cord-000372-wzwpyvll	597	29	phosphorylate	phosphorylate	VB
cord-000372-wzwpyvll	597	30	eIF4E	eif4e	CD
cord-000372-wzwpyvll	597	31	Phosphorylation	Phosphorylation	NNP
cord-000372-wzwpyvll	597	32	and	and	CC
cord-000372-wzwpyvll	597	33	dephosphorylation	dephosphorylation	NN
cord-000372-wzwpyvll	597	34	events	event	NNS
cord-000372-wzwpyvll	597	35	that	that	WDT
cord-000372-wzwpyvll	597	36	regulate	regulate	VBP
cord-000372-wzwpyvll	597	37	viral	viral	JJ
cord-000372-wzwpyvll	597	38	mRNA	mRNA	NNP
cord-000372-wzwpyvll	597	39	translation	translation	NN
cord-000372-wzwpyvll	597	40	Regulation	Regulation	NNP
cord-000372-wzwpyvll	597	41	of	of	IN
cord-000372-wzwpyvll	597	42	capdependent	capdependent	NN
cord-000372-wzwpyvll	597	43	translation	translation	NN
cord-000372-wzwpyvll	597	44	by	by	IN
cord-000372-wzwpyvll	597	45	eIF4E	eif4e	CD
cord-000372-wzwpyvll	597	46	inhibitory	inhibitory	JJ
cord-000372-wzwpyvll	597	47	proteins	protein	NNS
cord-000372-wzwpyvll	597	48	Differential	differential	JJ
cord-000372-wzwpyvll	597	49	cleavage	cleavage	NN
cord-000372-wzwpyvll	597	50	of	of	IN
cord-000372-wzwpyvll	597	51	eIF4GI	eif4gi	NN
cord-000372-wzwpyvll	597	52	and	and	CC
cord-000372-wzwpyvll	597	53	eIF4GII	eif4gii	NN
cord-000372-wzwpyvll	597	54	in	in	IN
cord-000372-wzwpyvll	597	55	mammalian	mammalian	JJ
cord-000372-wzwpyvll	597	56	cells	cell	NNS
cord-000372-wzwpyvll	597	57	:	:	:
cord-000372-wzwpyvll	597	58	effects	effect	NNS
cord-000372-wzwpyvll	597	59	on	on	IN
cord-000372-wzwpyvll	597	60	translation	translation	NN
cord-000372-wzwpyvll	597	61	Translation	translation	NN
cord-000372-wzwpyvll	597	62	of	of	IN
cord-000372-wzwpyvll	597	63	mRNAs	mRNAs	NNPS
cord-000372-wzwpyvll	597	64	from	from	IN
cord-000372-wzwpyvll	597	65	vesicular	vesicular	JJ
cord-000372-wzwpyvll	597	66	stomatitis	stomatitis	NN
cord-000372-wzwpyvll	597	67	virus	virus	NN
cord-000372-wzwpyvll	597	68	and	and	CC
cord-000372-wzwpyvll	597	69	vaccinia	vaccinia	NN
cord-000372-wzwpyvll	597	70	virus	virus	NN
cord-000372-wzwpyvll	597	71	is	be	VBZ
cord-000372-wzwpyvll	597	72	differentially	differentially	RB
cord-000372-wzwpyvll	597	73	blocked	block	VBN
cord-000372-wzwpyvll	597	74	in	in	IN
cord-000372-wzwpyvll	597	75	cells	cell	NNS
cord-000372-wzwpyvll	597	76	with	with	IN
cord-000372-wzwpyvll	597	77	depletion	depletion	NN
cord-000372-wzwpyvll	597	78	of	of	IN
cord-000372-wzwpyvll	597	79	eIF4GI	eif4gi	NN
cord-000372-wzwpyvll	597	80	and/or	and/or	CC
cord-000372-wzwpyvll	597	81	eIF4GII	eif4gii	FW
cord-000372-wzwpyvll	597	82	Eukaryotic	eukaryotic	JJ
cord-000372-wzwpyvll	597	83	translation	translation	NN
cord-000372-wzwpyvll	597	84	initiation	initiation	NN
cord-000372-wzwpyvll	597	85	factor	factor	NN
cord-000372-wzwpyvll	597	86	4	4	CD
cord-000372-wzwpyvll	597	87	G	g	NN
cord-000372-wzwpyvll	597	88	is	be	VBZ
cord-000372-wzwpyvll	597	89	targeted	target	VBN
cord-000372-wzwpyvll	597	90	for	for	IN
cord-000372-wzwpyvll	597	91	proteolytic	proteolytic	JJ
cord-000372-wzwpyvll	597	92	cleavage	cleavage	NN
cord-000372-wzwpyvll	597	93	by	by	IN
cord-000372-wzwpyvll	597	94	caspase	caspase	NN
cord-000372-wzwpyvll	597	95	3	3	CD
cord-000372-wzwpyvll	597	96	during	during	IN
cord-000372-wzwpyvll	597	97	inhibition	inhibition	NN
cord-000372-wzwpyvll	597	98	of	of	IN
cord-000372-wzwpyvll	597	99	translation	translation	NN
cord-000372-wzwpyvll	597	100	in	in	IN
cord-000372-wzwpyvll	597	101	apoptotic	apoptotic	JJ
cord-000372-wzwpyvll	597	102	cells	cell	NNS
cord-000372-wzwpyvll	598	1	Selective	selective	JJ
cord-000372-wzwpyvll	598	2	modification	modification	NN
cord-000372-wzwpyvll	598	3	of	of	IN
cord-000372-wzwpyvll	598	4	eukaryotic	eukaryotic	JJ
cord-000372-wzwpyvll	598	5	initiation	initiation	NN
cord-000372-wzwpyvll	598	6	factor	factor	NN
cord-000372-wzwpyvll	598	7	4F	4F	NNP
cord-000372-wzwpyvll	598	8	(	(	-LRB-
cord-000372-wzwpyvll	598	9	eIF4F	eif4f	CD
cord-000372-wzwpyvll	598	10	)	)	-RRB-
cord-000372-wzwpyvll	598	11	at	at	IN
cord-000372-wzwpyvll	598	12	the	the	DT
cord-000372-wzwpyvll	598	13	onset	onset	NN
cord-000372-wzwpyvll	598	14	of	of	IN
cord-000372-wzwpyvll	598	15	cell	cell	NN
cord-000372-wzwpyvll	598	16	differentiation	differentiation	NN
cord-000372-wzwpyvll	598	17	:	:	:
cord-000372-wzwpyvll	598	18	recruitment	recruitment	NN
cord-000372-wzwpyvll	598	19	of	of	IN
cord-000372-wzwpyvll	598	20	eIF4GII	eif4gii	NN
cord-000372-wzwpyvll	598	21	and	and	CC
cord-000372-wzwpyvll	598	22	long	long	RB
cord-000372-wzwpyvll	598	23	-	-	HYPH
cord-000372-wzwpyvll	598	24	lasting	last	VBG
cord-000372-wzwpyvll	598	25	phosphorylation	phosphorylation	NN
cord-000372-wzwpyvll	598	26	of	of	IN
cord-000372-wzwpyvll	598	27	eIF4E	eif4e	CD
cord-000372-wzwpyvll	598	28	Serum	serum	NN
cord-000372-wzwpyvll	598	29	-	-	HYPH
cord-000372-wzwpyvll	598	30	stimulated	stimulate	VBN
cord-000372-wzwpyvll	598	31	,	,	,
cord-000372-wzwpyvll	598	32	rapamycin	rapamycin	NN
cord-000372-wzwpyvll	598	33	-	-	HYPH
cord-000372-wzwpyvll	598	34	sensitive	sensitive	JJ
cord-000372-wzwpyvll	598	35	phosphorylation	phosphorylation	NN
cord-000372-wzwpyvll	598	36	sites	site	NNS
cord-000372-wzwpyvll	598	37	in	in	IN
cord-000372-wzwpyvll	598	38	the	the	DT
cord-000372-wzwpyvll	598	39	eukaryotic	eukaryotic	JJ
cord-000372-wzwpyvll	598	40	:	:	:
cord-000372-wzwpyvll	598	41	translation	translation	NN
cord-000372-wzwpyvll	598	42	initiation	initiation	NN
cord-000372-wzwpyvll	598	43	factor	factor	NN
cord-000372-wzwpyvll	598	44	4GI	4gi	CD
cord-000372-wzwpyvll	598	45	Inhibition	Inhibition	NNP
cord-000372-wzwpyvll	598	46	of	of	IN
cord-000372-wzwpyvll	598	47	capdependent	capdependent	NN
cord-000372-wzwpyvll	598	48	translation	translation	NN
cord-000372-wzwpyvll	598	49	via	via	IN
cord-000372-wzwpyvll	598	50	phosphorylation	phosphorylation	NN
cord-000372-wzwpyvll	598	51	of	of	IN
cord-000372-wzwpyvll	598	52	eIF4	eIF4	NNP
cord-000372-wzwpyvll	598	53	G	G	NNP
cord-000372-wzwpyvll	598	54	by	by	IN
cord-000372-wzwpyvll	598	55	20	20	CD
cord-000372-wzwpyvll	598	56	Journal	Journal	NNP
cord-000372-wzwpyvll	598	57	of	of	IN
cord-000372-wzwpyvll	598	58	Biomedicine	Biomedicine	NNP
cord-000372-wzwpyvll	598	59	and	and	CC
cord-000372-wzwpyvll	598	60	Biotechnology	Biotechnology	NNP
cord-000372-wzwpyvll	598	61	protein	protein	NN
cord-000372-wzwpyvll	598	62	kinase	kinase	NN
cord-000372-wzwpyvll	598	63	Pak2	Pak2	NNP
cord-000372-wzwpyvll	598	64	Suppression	Suppression	NNP
cord-000372-wzwpyvll	598	65	of	of	IN
cord-000372-wzwpyvll	598	66	cap	cap	NN
cord-000372-wzwpyvll	598	67	-	-	HYPH
cord-000372-wzwpyvll	598	68	dependent	dependent	JJ
cord-000372-wzwpyvll	598	69	translation	translation	NN
cord-000372-wzwpyvll	598	70	in	in	IN
cord-000372-wzwpyvll	598	71	mitosis	mitosis	NN
cord-000372-wzwpyvll	598	72	Phosphorylation	Phosphorylation	NNP
cord-000372-wzwpyvll	598	73	screening	screening	NN
cord-000372-wzwpyvll	598	74	identifies	identify	VBZ
cord-000372-wzwpyvll	598	75	translational	translational	JJ
cord-000372-wzwpyvll	598	76	initiation	initiation	NN
cord-000372-wzwpyvll	598	77	factor	factor	NN
cord-000372-wzwpyvll	598	78	4GII	4gii	CD
cord-000372-wzwpyvll	598	79	as	as	IN
cord-000372-wzwpyvll	598	80	an	an	DT
cord-000372-wzwpyvll	598	81	intracellular	intracellular	JJ
cord-000372-wzwpyvll	598	82	target	target	NN
cord-000372-wzwpyvll	598	83	of	of	IN
cord-000372-wzwpyvll	598	84	Ca	Ca	NNP
cord-000372-wzwpyvll	598	85	2	2	CD
cord-000372-wzwpyvll	598	86	+	+	CD
cord-000372-wzwpyvll	598	87	/calmodulin	/calmodulin	.
cord-000372-wzwpyvll	598	88	-	-	HYPH
cord-000372-wzwpyvll	598	89	dependent	dependent	JJ
cord-000372-wzwpyvll	598	90	protein	protein	NN
cord-000372-wzwpyvll	598	91	kinase	kinase	NN
cord-000372-wzwpyvll	598	92	I	-PRON-	PRP
cord-000372-wzwpyvll	598	93	Cleavage	cleavage	NN
cord-000372-wzwpyvll	598	94	of	of	IN
cord-000372-wzwpyvll	598	95	polypeptide	polypeptide	NN
cord-000372-wzwpyvll	598	96	chain	chain	NN
cord-000372-wzwpyvll	598	97	initiation	initiation	NN
cord-000372-wzwpyvll	598	98	factor	factor	NN
cord-000372-wzwpyvll	598	99	eIF4GI	eIF4GI	NNS
cord-000372-wzwpyvll	598	100	during	during	IN
cord-000372-wzwpyvll	598	101	apoptosis	apoptosis	NN
cord-000372-wzwpyvll	598	102	in	in	IN
cord-000372-wzwpyvll	598	103	lymphoma	lymphoma	NN
cord-000372-wzwpyvll	598	104	cells	cell	NNS
cord-000372-wzwpyvll	598	105	:	:	:
cord-000372-wzwpyvll	598	106	characterisation	characterisation	NN
cord-000372-wzwpyvll	598	107	of	of	IN
cord-000372-wzwpyvll	598	108	an	an	DT
cord-000372-wzwpyvll	598	109	internal	internal	JJ
cord-000372-wzwpyvll	598	110	fragment	fragment	NN
cord-000372-wzwpyvll	598	111	generated	generate	VBN
cord-000372-wzwpyvll	598	112	by	by	IN
cord-000372-wzwpyvll	598	113	caspase-3-mediated	caspase-3-mediated	JJ
cord-000372-wzwpyvll	598	114	cleavage	cleavage	NN
cord-000372-wzwpyvll	598	115	Cleavage	cleavage	NN
cord-000372-wzwpyvll	598	116	of	of	IN
cord-000372-wzwpyvll	598	117	eukaryotic	eukaryotic	JJ
cord-000372-wzwpyvll	598	118	translation	translation	NN
cord-000372-wzwpyvll	598	119	initiation	initiation	NN
cord-000372-wzwpyvll	598	120	factor	factor	NN
cord-000372-wzwpyvll	598	121	4GII	4gii	PRP
cord-000372-wzwpyvll	598	122	correlates	correlate	VBZ
cord-000372-wzwpyvll	598	123	with	with	IN
cord-000372-wzwpyvll	598	124	translation	translation	NN
cord-000372-wzwpyvll	598	125	inhibition	inhibition	NN
cord-000372-wzwpyvll	598	126	during	during	IN
cord-000372-wzwpyvll	598	127	apoptosis	apoptosis	NN
cord-000372-wzwpyvll	598	128	Translation	translation	NN
cord-000372-wzwpyvll	598	129	of	of	IN
cord-000372-wzwpyvll	598	130	eukaryotic	eukaryotic	JJ
cord-000372-wzwpyvll	598	131	translation	translation	NN
cord-000372-wzwpyvll	598	132	initiation	initiation	NN
cord-000372-wzwpyvll	598	133	factor	factor	NN
cord-000372-wzwpyvll	598	134	4GI	4GI	NNPS
cord-000372-wzwpyvll	598	135	(	(	-LRB-
cord-000372-wzwpyvll	598	136	eIF4GI	eIF4GI	NNS
cord-000372-wzwpyvll	598	137	)	)	-RRB-
cord-000372-wzwpyvll	598	138	proceeds	proceed	VBZ
cord-000372-wzwpyvll	598	139	from	from	IN
cord-000372-wzwpyvll	598	140	multiple	multiple	JJ
cord-000372-wzwpyvll	598	141	mRNAs	mRNAs	NNPS
cord-000372-wzwpyvll	598	142	containing	contain	VBG
cord-000372-wzwpyvll	598	143	a	a	DT
cord-000372-wzwpyvll	598	144	novel	novel	NN
cord-000372-wzwpyvll	598	145	capdependent	capdependent	NN
cord-000372-wzwpyvll	598	146	internal	internal	JJ
cord-000372-wzwpyvll	598	147	ribosome	ribosome	NN
cord-000372-wzwpyvll	598	148	entry	entry	NN
cord-000372-wzwpyvll	598	149	site	site	NN
cord-000372-wzwpyvll	598	150	(	(	-LRB-
cord-000372-wzwpyvll	598	151	IRES	IRES	NNP
cord-000372-wzwpyvll	598	152	)	)	-RRB-
cord-000372-wzwpyvll	598	153	that	that	WDT
cord-000372-wzwpyvll	598	154	is	be	VBZ
cord-000372-wzwpyvll	598	155	active	active	JJ
cord-000372-wzwpyvll	598	156	during	during	IN
cord-000372-wzwpyvll	598	157	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	598	158	infection	infection	NN
cord-000372-wzwpyvll	598	159	Generation	generation	NN
cord-000372-wzwpyvll	598	160	of	of	IN
cord-000372-wzwpyvll	598	161	multiple	multiple	JJ
cord-000372-wzwpyvll	598	162	isoforms	isoform	NNS
cord-000372-wzwpyvll	598	163	of	of	IN
cord-000372-wzwpyvll	598	164	eukaryotic	eukaryotic	JJ
cord-000372-wzwpyvll	598	165	translation	translation	NN
cord-000372-wzwpyvll	598	166	initiation	initiation	NN
cord-000372-wzwpyvll	598	167	factor	factor	NN
cord-000372-wzwpyvll	598	168	4GI	4GI	NNS
cord-000372-wzwpyvll	598	169	by	by	IN
cord-000372-wzwpyvll	598	170	use	use	NN
cord-000372-wzwpyvll	598	171	of	of	IN
cord-000372-wzwpyvll	598	172	alternate	alternate	JJ
cord-000372-wzwpyvll	598	173	translation	translation	NN
cord-000372-wzwpyvll	598	174	initiation	initiation	NN
cord-000372-wzwpyvll	598	175	codons	codon	NNS
cord-000372-wzwpyvll	598	176	Specific	specific	JJ
cord-000372-wzwpyvll	598	177	isoforms	isoform	NNS
cord-000372-wzwpyvll	598	178	of	of	IN
cord-000372-wzwpyvll	598	179	translation	translation	NN
cord-000372-wzwpyvll	598	180	initiation	initiation	NN
cord-000372-wzwpyvll	598	181	factor	factor	NN
cord-000372-wzwpyvll	598	182	4GI	4gi	CD
cord-000372-wzwpyvll	598	183	show	show	VBP
cord-000372-wzwpyvll	598	184	differences	difference	NNS
cord-000372-wzwpyvll	598	185	in	in	IN
cord-000372-wzwpyvll	598	186	translational	translational	JJ
cord-000372-wzwpyvll	598	187	activity	activity	NN
cord-000372-wzwpyvll	598	188	Regulation	regulation	NN
cord-000372-wzwpyvll	598	189	of	of	IN
cord-000372-wzwpyvll	598	190	protein	protein	NN
cord-000372-wzwpyvll	598	191	synthesis	synthesis	NN
cord-000372-wzwpyvll	598	192	in	in	IN
cord-000372-wzwpyvll	598	193	HeLa	HeLa	NNP
cord-000372-wzwpyvll	598	194	cells	cell	NNS
cord-000372-wzwpyvll	598	195	.	.	.
cord-000372-wzwpyvll	599	1	3	3	LS
cord-000372-wzwpyvll	599	2	.	.	.
cord-000372-wzwpyvll	600	1	Inhibition	inhibition	NN
cord-000372-wzwpyvll	600	2	during	during	IN
cord-000372-wzwpyvll	600	3	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	600	4	infection	infection	NN
cord-000372-wzwpyvll	600	5	Control	Control	NNP
cord-000372-wzwpyvll	600	6	of	of	IN
cord-000372-wzwpyvll	600	7	protein	protein	NN
cord-000372-wzwpyvll	600	8	synthesis	synthesis	NN
cord-000372-wzwpyvll	600	9	in	in	IN
cord-000372-wzwpyvll	600	10	extracts	extract	NNS
cord-000372-wzwpyvll	600	11	from	from	IN
cord-000372-wzwpyvll	600	12	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	600	13	-	-	HYPH
cord-000372-wzwpyvll	600	14	infected	infect	VBN
cord-000372-wzwpyvll	600	15	cells	cell	NNS
cord-000372-wzwpyvll	600	16	.	.	.
cord-000372-wzwpyvll	601	1	I.	I.	NNP
cord-000372-wzwpyvll	601	2	mRNA	mrna	NN
cord-000372-wzwpyvll	602	1	discrimination	discrimination	NN
cord-000372-wzwpyvll	602	2	by	by	IN
cord-000372-wzwpyvll	602	3	crude	crude	JJ
cord-000372-wzwpyvll	602	4	initiation	initiation	NN
cord-000372-wzwpyvll	602	5	factors	factor	NNS
cord-000372-wzwpyvll	603	1	Poliovirus	Poliovirus	NNP
cord-000372-wzwpyvll	603	2	proteinase	proteinase	NN
cord-000372-wzwpyvll	603	3	2A	2a	NN
cord-000372-wzwpyvll	603	4	induces	induce	VBZ
cord-000372-wzwpyvll	603	5	cleavage	cleavage	NN
cord-000372-wzwpyvll	603	6	of	of	IN
cord-000372-wzwpyvll	603	7	eucaryotic	eucaryotic	JJ
cord-000372-wzwpyvll	603	8	initiation	initiation	NN
cord-000372-wzwpyvll	603	9	factor	factor	NN
cord-000372-wzwpyvll	603	10	4f	4f	CD
cord-000372-wzwpyvll	603	11	polypeptide	polypeptide	NN
cord-000372-wzwpyvll	604	1	p220	p220	NNP
cord-000372-wzwpyvll	604	2	A	a	DT
cord-000372-wzwpyvll	604	3	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	604	4	2A(pro	2a(pro	CD
cord-000372-wzwpyvll	604	5	)	)	-RRB-
cord-000372-wzwpyvll	604	6	mutant	mutant	NN
cord-000372-wzwpyvll	604	7	unable	unable	JJ
cord-000372-wzwpyvll	604	8	to	to	TO
cord-000372-wzwpyvll	604	9	cleave	cleave	VB
cord-000372-wzwpyvll	604	10	3CD	3CD	NNP
cord-000372-wzwpyvll	604	11	shows	show	VBZ
cord-000372-wzwpyvll	604	12	inefficient	inefficient	JJ
cord-000372-wzwpyvll	604	13	viral	viral	JJ
cord-000372-wzwpyvll	604	14	protein	protein	NN
cord-000372-wzwpyvll	604	15	synthesis	synthesis	NN
cord-000372-wzwpyvll	604	16	and	and	CC
cord-000372-wzwpyvll	604	17	transactivation	transactivation	NN
cord-000372-wzwpyvll	604	18	defects	defect	VBZ
cord-000372-wzwpyvll	604	19	Direct	direct	JJ
cord-000372-wzwpyvll	604	20	cleavage	cleavage	NN
cord-000372-wzwpyvll	604	21	of	of	IN
cord-000372-wzwpyvll	604	22	elF4	elf4	JJ
cord-000372-wzwpyvll	604	23	G	g	NN
cord-000372-wzwpyvll	604	24	by	by	IN
cord-000372-wzwpyvll	604	25	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	605	1	2A	2A	NNP
cord-000372-wzwpyvll	605	2	protease	protease	NN
cord-000372-wzwpyvll	605	3	is	be	VBZ
cord-000372-wzwpyvll	605	4	inefficient	inefficient	JJ
cord-000372-wzwpyvll	605	5	in	in	IN
cord-000372-wzwpyvll	605	6	vitro	vitro	FW
cord-000372-wzwpyvll	605	7	Human	human	JJ
cord-000372-wzwpyvll	605	8	rhinovirus	rhinovirus	NN
cord-000372-wzwpyvll	605	9	14	14	CD
cord-000372-wzwpyvll	605	10	infection	infection	NN
cord-000372-wzwpyvll	605	11	of	of	IN
cord-000372-wzwpyvll	605	12	HeLa	HeLa	NNP
cord-000372-wzwpyvll	605	13	cells	cell	NNS
cord-000372-wzwpyvll	605	14	results	result	NNS
cord-000372-wzwpyvll	605	15	in	in	IN
cord-000372-wzwpyvll	605	16	the	the	DT
cord-000372-wzwpyvll	605	17	proteolytic	proteolytic	JJ
cord-000372-wzwpyvll	605	18	cleavage	cleavage	NN
cord-000372-wzwpyvll	605	19	of	of	IN
cord-000372-wzwpyvll	605	20	the	the	DT
cord-000372-wzwpyvll	605	21	p220	p220	NNP
cord-000372-wzwpyvll	605	22	cap	cap	NN
cord-000372-wzwpyvll	605	23	-	-	HYPH
cord-000372-wzwpyvll	605	24	binding	bind	VBG
cord-000372-wzwpyvll	605	25	complex	complex	JJ
cord-000372-wzwpyvll	605	26	subunit	subunit	NN
cord-000372-wzwpyvll	605	27	and	and	CC
cord-000372-wzwpyvll	605	28	inactivates	inactivate	VBZ
cord-000372-wzwpyvll	605	29	globin	globin	NN
cord-000372-wzwpyvll	605	30	mRNA	mRNA	NNP
cord-000372-wzwpyvll	605	31	translation	translation	NN
cord-000372-wzwpyvll	605	32	in	in	IN
cord-000372-wzwpyvll	605	33	vitro	vitro	FW
cord-000372-wzwpyvll	606	1	Mapping	map	VBG
cord-000372-wzwpyvll	606	2	the	the	DT
cord-000372-wzwpyvll	606	3	cleavage	cleavage	NN
cord-000372-wzwpyvll	606	4	site	site	NN
cord-000372-wzwpyvll	606	5	in	in	IN
cord-000372-wzwpyvll	606	6	protein	protein	NN
cord-000372-wzwpyvll	606	7	synthesis	synthesis	NN
cord-000372-wzwpyvll	606	8	initiation	initiation	NN
cord-000372-wzwpyvll	606	9	factor	factor	NN
cord-000372-wzwpyvll	606	10	eIF-4γ	eIF-4γ	NNP
cord-000372-wzwpyvll	606	11	of	of	IN
cord-000372-wzwpyvll	606	12	the	the	DT
cord-000372-wzwpyvll	606	13	2A	2a	CD
cord-000372-wzwpyvll	606	14	proteases	protease	NNS
cord-000372-wzwpyvll	606	15	from	from	IN
cord-000372-wzwpyvll	606	16	human	human	JJ
cord-000372-wzwpyvll	606	17	Coxsackievirus	Coxsackievirus	NNP
cord-000372-wzwpyvll	606	18	and	and	CC
cord-000372-wzwpyvll	606	19	rhinovirus	rhinovirus	NN
cord-000372-wzwpyvll	606	20	2A	2A	NNP
cord-000372-wzwpyvll	606	21	proteinases	proteinases	NNP
cord-000372-wzwpyvll	606	22	of	of	IN
cord-000372-wzwpyvll	606	23	coxsackie	coxsackie	NNP
cord-000372-wzwpyvll	606	24	-	-	:
cord-000372-wzwpyvll	606	25	and	and	CC
cord-000372-wzwpyvll	606	26	rhinovirus	rhinovirus	NN
cord-000372-wzwpyvll	606	27	cleave	cleave	NN
cord-000372-wzwpyvll	606	28	peptides	peptide	NNS
cord-000372-wzwpyvll	606	29	derived	derive	VBN
cord-000372-wzwpyvll	606	30	from	from	IN
cord-000372-wzwpyvll	606	31	eIF-4	eIF-4	NNP
cord-000372-wzwpyvll	606	32	gamma	gamma	NN
cord-000372-wzwpyvll	606	33	via	via	IN
cord-000372-wzwpyvll	606	34	a	a	DT
cord-000372-wzwpyvll	606	35	common	common	JJ
cord-000372-wzwpyvll	606	36	recognition	recognition	NN
cord-000372-wzwpyvll	606	37	motif	motif	NN
cord-000372-wzwpyvll	607	1	The	the	DT
cord-000372-wzwpyvll	607	2	eIF4G	eif4g	CD
cord-000372-wzwpyvll	607	3	-	-	HYPH
cord-000372-wzwpyvll	607	4	eIF4E	eif4e	CD
cord-000372-wzwpyvll	607	5	complex	complex	NN
cord-000372-wzwpyvll	607	6	is	be	VBZ
cord-000372-wzwpyvll	607	7	the	the	DT
cord-000372-wzwpyvll	607	8	target	target	NN
cord-000372-wzwpyvll	607	9	for	for	IN
cord-000372-wzwpyvll	607	10	direct	direct	JJ
cord-000372-wzwpyvll	607	11	cleavage	cleavage	NN
cord-000372-wzwpyvll	607	12	by	by	IN
cord-000372-wzwpyvll	607	13	the	the	DT
cord-000372-wzwpyvll	607	14	rhinovirus	rhinovirus	NN
cord-000372-wzwpyvll	607	15	2A	2a	CD
cord-000372-wzwpyvll	607	16	proteinase	proteinase	NN
cord-000372-wzwpyvll	608	1	Poliovirus	Poliovirus	NNP
cord-000372-wzwpyvll	608	2	2A	2a	NN
cord-000372-wzwpyvll	608	3	proteinase	proteinase	NN
cord-000372-wzwpyvll	608	4	cleaves	cleave	VBZ
cord-000372-wzwpyvll	608	5	directly	directly	RB
cord-000372-wzwpyvll	608	6	the	the	DT
cord-000372-wzwpyvll	608	7	eIF-4	eIF-4	NNP
cord-000372-wzwpyvll	608	8	G	G	NNP
cord-000372-wzwpyvll	608	9	subunit	subunit	NN
cord-000372-wzwpyvll	608	10	of	of	IN
cord-000372-wzwpyvll	608	11	eIF-4F	eif-4f	NN
cord-000372-wzwpyvll	608	12	complex	complex	JJ
cord-000372-wzwpyvll	608	13	Relationship	relationship	NN
cord-000372-wzwpyvll	608	14	of	of	IN
cord-000372-wzwpyvll	608	15	eukaryotic	eukaryotic	JJ
cord-000372-wzwpyvll	608	16	initiation	initiation	NN
cord-000372-wzwpyvll	608	17	factor	factor	NN
cord-000372-wzwpyvll	608	18	3	3	CD
cord-000372-wzwpyvll	608	19	to	to	IN
cord-000372-wzwpyvll	608	20	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	608	21	-	-	HYPH
cord-000372-wzwpyvll	608	22	induced	induce	VBN
cord-000372-wzwpyvll	608	23	p220	p220	NN
cord-000372-wzwpyvll	608	24	cleavage	cleavage	NN
cord-000372-wzwpyvll	608	25	activity	activity	NN
cord-000372-wzwpyvll	609	1	Multiple	multiple	JJ
cord-000372-wzwpyvll	609	2	eIF4GI	eif4gi	RB
cord-000372-wzwpyvll	609	3	-	-	HYPH
cord-000372-wzwpyvll	609	4	specific	specific	JJ
cord-000372-wzwpyvll	609	5	protease	protease	NN
cord-000372-wzwpyvll	609	6	activities	activity	NNS
cord-000372-wzwpyvll	609	7	present	present	JJ
cord-000372-wzwpyvll	609	8	in	in	IN
cord-000372-wzwpyvll	609	9	uninfected	uninfected	JJ
cord-000372-wzwpyvll	609	10	and	and	CC
cord-000372-wzwpyvll	609	11	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	609	12	-	-	HYPH
cord-000372-wzwpyvll	609	13	infected	infect	VBN
cord-000372-wzwpyvll	609	14	cells	cell	NNS
cord-000372-wzwpyvll	609	15	Lack	lack	VBP
cord-000372-wzwpyvll	609	16	of	of	IN
cord-000372-wzwpyvll	609	17	direct	direct	JJ
cord-000372-wzwpyvll	609	18	correlation	correlation	NN
cord-000372-wzwpyvll	609	19	between	between	IN
cord-000372-wzwpyvll	609	20	p220	p220	NNP
cord-000372-wzwpyvll	609	21	cleavage	cleavage	NN
cord-000372-wzwpyvll	609	22	and	and	CC
cord-000372-wzwpyvll	609	23	the	the	DT
cord-000372-wzwpyvll	609	24	shut	shut	NN
cord-000372-wzwpyvll	609	25	-	-	HYPH
cord-000372-wzwpyvll	609	26	off	off	NN
cord-000372-wzwpyvll	609	27	of	of	IN
cord-000372-wzwpyvll	609	28	host	host	NN
cord-000372-wzwpyvll	609	29	translation	translation	NN
cord-000372-wzwpyvll	609	30	after	after	IN
cord-000372-wzwpyvll	609	31	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	609	32	infection	infection	NN
cord-000372-wzwpyvll	609	33	Monensin	Monensin	NNP
cord-000372-wzwpyvll	609	34	and	and	CC
cord-000372-wzwpyvll	609	35	nigericin	nigericin	NNS
cord-000372-wzwpyvll	609	36	prevent	prevent	VBP
cord-000372-wzwpyvll	609	37	the	the	DT
cord-000372-wzwpyvll	609	38	inhibition	inhibition	NN
cord-000372-wzwpyvll	609	39	of	of	IN
cord-000372-wzwpyvll	609	40	host	host	NN
cord-000372-wzwpyvll	609	41	translation	translation	NN
cord-000372-wzwpyvll	609	42	by	by	IN
cord-000372-wzwpyvll	609	43	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	609	44	,	,	,
cord-000372-wzwpyvll	609	45	without	without	IN
cord-000372-wzwpyvll	609	46	affecting	affect	VBG
cord-000372-wzwpyvll	609	47	p220	p220	NN
cord-000372-wzwpyvll	609	48	cleavage	cleavage	NN
cord-000372-wzwpyvll	609	49	Proteolysis	Proteolysis	NNP
cord-000372-wzwpyvll	609	50	of	of	IN
cord-000372-wzwpyvll	609	51	human	human	JJ
cord-000372-wzwpyvll	609	52	eukaryotic	eukaryotic	JJ
cord-000372-wzwpyvll	609	53	translation	translation	NN
cord-000372-wzwpyvll	609	54	initiation	initiation	NN
cord-000372-wzwpyvll	609	55	factor	factor	NN
cord-000372-wzwpyvll	609	56	eIF4GII	eif4gii	NN
cord-000372-wzwpyvll	609	57	,	,	,
cord-000372-wzwpyvll	609	58	but	but	CC
cord-000372-wzwpyvll	609	59	not	not	RB
cord-000372-wzwpyvll	609	60	EIF4GI	EIF4GI	NNS
cord-000372-wzwpyvll	609	61	,	,	,
cord-000372-wzwpyvll	609	62	coincides	coincide	VBZ
cord-000372-wzwpyvll	609	63	with	with	IN
cord-000372-wzwpyvll	609	64	the	the	DT
cord-000372-wzwpyvll	609	65	shutoff	shutoff	NN
cord-000372-wzwpyvll	609	66	of	of	IN
cord-000372-wzwpyvll	609	67	host	host	NN
cord-000372-wzwpyvll	609	68	protein	protein	NN
cord-000372-wzwpyvll	609	69	synthesis	synthesis	NN
cord-000372-wzwpyvll	609	70	after	after	IN
cord-000372-wzwpyvll	609	71	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	609	72	infection	infection	NN
cord-000372-wzwpyvll	609	73	Eukaryotic	eukaryotic	JJ
cord-000372-wzwpyvll	609	74	initiation	initiation	NN
cord-000372-wzwpyvll	609	75	factor	factor	NN
cord-000372-wzwpyvll	609	76	4GII	4GII	NNP
cord-000372-wzwpyvll	609	77	(	(	-LRB-
cord-000372-wzwpyvll	609	78	eIF4GII	eif4gii	NN
cord-000372-wzwpyvll	609	79	)	)	-RRB-
cord-000372-wzwpyvll	609	80	,	,	,
cord-000372-wzwpyvll	609	81	but	but	CC
cord-000372-wzwpyvll	609	82	not	not	RB
cord-000372-wzwpyvll	609	83	eIF4GI	eif4gi	NN
cord-000372-wzwpyvll	609	84	,	,	,
cord-000372-wzwpyvll	609	85	cleavage	cleavage	NN
cord-000372-wzwpyvll	609	86	correlates	correlate	VBZ
cord-000372-wzwpyvll	609	87	with	with	IN
cord-000372-wzwpyvll	609	88	inhibition	inhibition	NN
cord-000372-wzwpyvll	609	89	of	of	IN
cord-000372-wzwpyvll	609	90	host	host	NN
cord-000372-wzwpyvll	609	91	cell	cell	NN
cord-000372-wzwpyvll	609	92	protein	protein	NN
cord-000372-wzwpyvll	609	93	synthesis	synthesis	NN
cord-000372-wzwpyvll	609	94	after	after	IN
cord-000372-wzwpyvll	609	95	human	human	JJ
cord-000372-wzwpyvll	609	96	rhinovirus	rhinovirus	NN
cord-000372-wzwpyvll	609	97	infection	infection	NN
cord-000372-wzwpyvll	609	98	High	high	JJ
cord-000372-wzwpyvll	609	99	level	level	NN
cord-000372-wzwpyvll	609	100	expression	expression	NN
cord-000372-wzwpyvll	609	101	in	in	IN
cord-000372-wzwpyvll	609	102	Escherichia	Escherichia	NNP
cord-000372-wzwpyvll	609	103	coli	coli	NNS
cord-000372-wzwpyvll	609	104	cells	cell	NNS
cord-000372-wzwpyvll	609	105	and	and	CC
cord-000372-wzwpyvll	609	106	purification	purification	NN
cord-000372-wzwpyvll	609	107	of	of	IN
cord-000372-wzwpyvll	609	108	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	609	109	protein	protein	NN
cord-000372-wzwpyvll	609	110	2A(pro	2a(pro	CD
cord-000372-wzwpyvll	609	111	)	)	-RRB-
cord-000372-wzwpyvll	609	112	Cleavage	cleavage	NN
cord-000372-wzwpyvll	609	113	of	of	IN
cord-000372-wzwpyvll	609	114	p220	p220	NNP
cord-000372-wzwpyvll	609	115	by	by	IN
cord-000372-wzwpyvll	609	116	purified	purify	VBN
cord-000372-wzwpyvll	609	117	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	609	118	2A(pro	2a(pro	CD
cord-000372-wzwpyvll	609	119	)	)	-RRB-
cord-000372-wzwpyvll	609	120	in	in	IN
cord-000372-wzwpyvll	609	121	cell	cell	NN
cord-000372-wzwpyvll	609	122	-	-	HYPH
cord-000372-wzwpyvll	609	123	free	free	JJ
cord-000372-wzwpyvll	609	124	systems	system	NNS
cord-000372-wzwpyvll	609	125	:	:	:
cord-000372-wzwpyvll	609	126	effects	effect	NNS
cord-000372-wzwpyvll	609	127	on	on	IN
cord-000372-wzwpyvll	609	128	translation	translation	NN
cord-000372-wzwpyvll	609	129	of	of	IN
cord-000372-wzwpyvll	609	130	capped	capped	JJ
cord-000372-wzwpyvll	609	131	and	and	CC
cord-000372-wzwpyvll	609	132	uncapped	uncapped	JJ
cord-000372-wzwpyvll	609	133	mRNAs	mRNAs	.
cord-000372-wzwpyvll	610	1	Poly(A)-binding	poly(a)-binde	VBG
cord-000372-wzwpyvll	610	2	protein	protein	NN
cord-000372-wzwpyvll	610	3	interaction	interaction	NN
cord-000372-wzwpyvll	610	4	with	with	IN
cord-000372-wzwpyvll	610	5	elF4	elf4	JJ
cord-000372-wzwpyvll	610	6	G	G	NNP
cord-000372-wzwpyvll	610	7	stimulates	stimulate	VBZ
cord-000372-wzwpyvll	610	8	picornavirus	picornavirus	NN
cord-000372-wzwpyvll	610	9	IRES	IRES	NNP
cord-000372-wzwpyvll	610	10	-	-	HYPH
cord-000372-wzwpyvll	610	11	dependent	dependent	JJ
cord-000372-wzwpyvll	610	12	translation	translation	NN
cord-000372-wzwpyvll	610	13	HIV-1	HIV-1	NNP
cord-000372-wzwpyvll	610	14	protease	protease	NN
cord-000372-wzwpyvll	610	15	inhibits	inhibit	VBZ
cord-000372-wzwpyvll	610	16	cap	cap	NN
cord-000372-wzwpyvll	610	17	-	-	:
cord-000372-wzwpyvll	610	18	and	and	CC
cord-000372-wzwpyvll	610	19	poly(A)-dependent	poly(a)-dependent	CD
cord-000372-wzwpyvll	610	20	translation	translation	NN
cord-000372-wzwpyvll	610	21	upon	upon	IN
cord-000372-wzwpyvll	610	22	eIF4GI	eIF4GI	NNS
cord-000372-wzwpyvll	610	23	and	and	CC
cord-000372-wzwpyvll	610	24	PABP	PABP	NNP
cord-000372-wzwpyvll	610	25	cleavage	cleavage	NN
cord-000372-wzwpyvll	610	26	Human	Human	NNP
cord-000372-wzwpyvll	610	27	immunodeficiency	immunodeficiency	NN
cord-000372-wzwpyvll	610	28	virus	virus	NN
cord-000372-wzwpyvll	610	29	tat	tat	NN
cord-000372-wzwpyvll	610	30	-	-	HYPH
cord-000372-wzwpyvll	610	31	activated	activate	VBN
cord-000372-wzwpyvll	610	32	expression	expression	NN
cord-000372-wzwpyvll	610	33	of	of	IN
cord-000372-wzwpyvll	610	34	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	610	35	protein	protein	NN
cord-000372-wzwpyvll	610	36	2A	2a	CD
cord-000372-wzwpyvll	611	1	inhibits	inhibit	NNS
cord-000372-wzwpyvll	612	1	mRNA	mRNA	NNP
cord-000372-wzwpyvll	612	2	translation	translation	NN
cord-000372-wzwpyvll	613	1	The	the	DT
cord-000372-wzwpyvll	613	2	effect	effect	NN
cord-000372-wzwpyvll	613	3	of	of	IN
cord-000372-wzwpyvll	613	4	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	613	5	proteinase	proteinase	NN
cord-000372-wzwpyvll	613	6	2A(pro	2a(pro	CD
cord-000372-wzwpyvll	613	7	)	)	-RRB-
cord-000372-wzwpyvll	613	8	expression	expression	NN
cord-000372-wzwpyvll	613	9	on	on	IN
cord-000372-wzwpyvll	613	10	cellular	cellular	JJ
cord-000372-wzwpyvll	613	11	metabolism	metabolism	NN
cord-000372-wzwpyvll	613	12	.	.	.
cord-000372-wzwpyvll	614	1	Inhibition	inhibition	NN
cord-000372-wzwpyvll	614	2	of	of	IN
cord-000372-wzwpyvll	614	3	DNA	dna	NN
cord-000372-wzwpyvll	614	4	replication	replication	NN
cord-000372-wzwpyvll	614	5	,	,	,
cord-000372-wzwpyvll	614	6	RNA	RNA	NNP
cord-000372-wzwpyvll	614	7	polymerase	polymerase	NN
cord-000372-wzwpyvll	614	8	II	II	NNP
cord-000372-wzwpyvll	614	9	transcription	transcription	NN
cord-000372-wzwpyvll	614	10	,	,	,
cord-000372-wzwpyvll	614	11	and	and	CC
cord-000372-wzwpyvll	614	12	translation	translation	NN
cord-000372-wzwpyvll	614	13	Expression	expression	NN
cord-000372-wzwpyvll	614	14	of	of	IN
cord-000372-wzwpyvll	614	15	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	614	16	2A(pro	2a(pro	CD
cord-000372-wzwpyvll	614	17	)	)	-RRB-
cord-000372-wzwpyvll	614	18	in	in	IN
cord-000372-wzwpyvll	614	19	mammalian	mammalian	JJ
cord-000372-wzwpyvll	614	20	cells	cell	NNS
cord-000372-wzwpyvll	614	21	:	:	:
cord-000372-wzwpyvll	614	22	effects	effect	NNS
cord-000372-wzwpyvll	614	23	on	on	IN
cord-000372-wzwpyvll	614	24	translation	translation	NN
cord-000372-wzwpyvll	614	25	Efficient	efficient	JJ
cord-000372-wzwpyvll	614	26	cleavage	cleavage	NN
cord-000372-wzwpyvll	614	27	of	of	IN
cord-000372-wzwpyvll	614	28	p220	p220	NN
cord-000372-wzwpyvll	614	29	by	by	IN
cord-000372-wzwpyvll	614	30	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	614	31	2A(pro	2a(pro	CD
cord-000372-wzwpyvll	614	32	)	)	-RRB-
cord-000372-wzwpyvll	614	33	expression	expression	NN
cord-000372-wzwpyvll	614	34	in	in	IN
cord-000372-wzwpyvll	614	35	mammalian	mammalian	JJ
cord-000372-wzwpyvll	614	36	cells	cell	NNS
cord-000372-wzwpyvll	614	37	:	:	:
cord-000372-wzwpyvll	614	38	effects	effect	NNS
cord-000372-wzwpyvll	614	39	on	on	IN
cord-000372-wzwpyvll	614	40	vaccinia	vaccinia	NN
cord-000372-wzwpyvll	614	41	virus	virus	NN
cord-000372-wzwpyvll	614	42	Hybrid	hybrid	NN
cord-000372-wzwpyvll	614	43	proteins	protein	NNS
cord-000372-wzwpyvll	614	44	between	between	IN
cord-000372-wzwpyvll	614	45	pseudomonas	pseudomonas	NN
cord-000372-wzwpyvll	614	46	exotoxin	exotoxin	NN
cord-000372-wzwpyvll	614	47	a	a	DT
cord-000372-wzwpyvll	614	48	and	and	CC
cord-000372-wzwpyvll	614	49	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	614	50	protease	protease	NN
cord-000372-wzwpyvll	614	51	2A(pro	2a(pro	CD
cord-000372-wzwpyvll	614	52	)	)	-RRB-
cord-000372-wzwpyvll	614	53	Effects	effect	NNS
cord-000372-wzwpyvll	614	54	of	of	IN
cord-000372-wzwpyvll	614	55	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	614	56	2A(pro	2a(pro	CD
cord-000372-wzwpyvll	614	57	)	)	-RRB-
cord-000372-wzwpyvll	614	58	on	on	IN
cord-000372-wzwpyvll	614	59	vaccinia	vaccinia	NN
cord-000372-wzwpyvll	614	60	virus	virus	NN
cord-000372-wzwpyvll	614	61	gene	gene	NN
cord-000372-wzwpyvll	614	62	expression	expression	NN
cord-000372-wzwpyvll	615	1	The	the	DT
cord-000372-wzwpyvll	615	2	eukaryotic	eukaryotic	JJ
cord-000372-wzwpyvll	615	3	translation	translation	NN
cord-000372-wzwpyvll	615	4	initiation	initiation	NN
cord-000372-wzwpyvll	615	5	factor	factor	NN
cord-000372-wzwpyvll	615	6	4GI	4gi	CD
cord-000372-wzwpyvll	615	7	is	be	VBZ
cord-000372-wzwpyvll	615	8	cleaved	cleave	VBN
cord-000372-wzwpyvll	615	9	by	by	IN
cord-000372-wzwpyvll	615	10	different	different	JJ
cord-000372-wzwpyvll	615	11	retroviral	retroviral	NN
cord-000372-wzwpyvll	615	12	proteases	protease	NNS
cord-000372-wzwpyvll	615	13	Hybrid	hybrid	NN
cord-000372-wzwpyvll	615	14	proteins	protein	NNS
cord-000372-wzwpyvll	615	15	between	between	IN
cord-000372-wzwpyvll	615	16	pseudomonas	pseudomonas	NN
cord-000372-wzwpyvll	615	17	aeruginosa	aeruginosa	NN
cord-000372-wzwpyvll	615	18	exotoxin	exotoxin	NN
cord-000372-wzwpyvll	615	19	A	a	NN
cord-000372-wzwpyvll	615	20	and	and	CC
cord-000372-wzwpyvll	615	21	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	615	22	2Apro	2apro	CD
cord-000372-wzwpyvll	615	23	cleave	cleave	VB
cord-000372-wzwpyvll	615	24	p220	p220	NNP
cord-000372-wzwpyvll	615	25	in	in	IN
cord-000372-wzwpyvll	615	26	HeLa	HeLa	NNP
cord-000372-wzwpyvll	615	27	cells	cell	NNS
cord-000372-wzwpyvll	615	28	Cleavage	cleavage	NN
cord-000372-wzwpyvll	615	29	of	of	IN
cord-000372-wzwpyvll	615	30	eukaryotic	eukaryotic	JJ
cord-000372-wzwpyvll	615	31	translation	translation	NN
cord-000372-wzwpyvll	615	32	initiation	initiation	NN
cord-000372-wzwpyvll	615	33	factor	factor	NN
cord-000372-wzwpyvll	615	34	4	4	CD
cord-000372-wzwpyvll	615	35	G	g	NN
cord-000372-wzwpyvll	615	36	by	by	IN
cord-000372-wzwpyvll	615	37	exogenously	exogenously	RB
cord-000372-wzwpyvll	615	38	added	add	VBN
cord-000372-wzwpyvll	615	39	hybrid	hybrid	JJ
cord-000372-wzwpyvll	615	40	proteins	protein	NNS
cord-000372-wzwpyvll	615	41	containing	contain	VBG
cord-000372-wzwpyvll	615	42	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	615	43	2A(pro	2a(pro	CD
cord-000372-wzwpyvll	615	44	)	)	-RRB-
cord-000372-wzwpyvll	616	1	in	in	IN
cord-000372-wzwpyvll	616	2	HeLa	HeLa	NNP
cord-000372-wzwpyvll	616	3	cells	cell	NNS
cord-000372-wzwpyvll	616	4	:	:	:
cord-000372-wzwpyvll	616	5	effects	effect	NNS
cord-000372-wzwpyvll	616	6	on	on	IN
cord-000372-wzwpyvll	616	7	gene	gene	NN
cord-000372-wzwpyvll	616	8	expression	expression	NN
cord-000372-wzwpyvll	617	1	A	a	DT
cord-000372-wzwpyvll	617	2	stable	stable	JJ
cord-000372-wzwpyvll	617	3	HeLa	HeLa	NNP
cord-000372-wzwpyvll	617	4	cell	cell	NN
cord-000372-wzwpyvll	617	5	line	line	NN
cord-000372-wzwpyvll	617	6	that	that	WDT
cord-000372-wzwpyvll	617	7	inducibly	inducibly	RB
cord-000372-wzwpyvll	617	8	expresses	express	VBZ
cord-000372-wzwpyvll	617	9	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	617	10	2A(pro	2a(pro	CD
cord-000372-wzwpyvll	617	11	)	)	-RRB-
cord-000372-wzwpyvll	617	12	:	:	:
cord-000372-wzwpyvll	617	13	effects	effect	NNS
cord-000372-wzwpyvll	617	14	on	on	IN
cord-000372-wzwpyvll	617	15	cellular	cellular	JJ
cord-000372-wzwpyvll	617	16	and	and	CC
cord-000372-wzwpyvll	617	17	viral	viral	JJ
cord-000372-wzwpyvll	617	18	gene	gene	NN
cord-000372-wzwpyvll	617	19	expression	expression	NN
cord-000372-wzwpyvll	618	1	Poliovirus	Poliovirus	NNP
cord-000372-wzwpyvll	618	2	2A	2a	CD
cord-000372-wzwpyvll	618	3	protease	protease	NN
cord-000372-wzwpyvll	618	4	induces	induce	VBZ
cord-000372-wzwpyvll	618	5	apoptotic	apoptotic	JJ
cord-000372-wzwpyvll	618	6	cell	cell	NN
cord-000372-wzwpyvll	618	7	death	death	NN
cord-000372-wzwpyvll	619	1	eIF4	eif4	IN
cord-000372-wzwpyvll	619	2	G	G	NNP
cord-000372-wzwpyvll	619	3	is	be	VBZ
cord-000372-wzwpyvll	619	4	required	require	VBN
cord-000372-wzwpyvll	619	5	for	for	IN
cord-000372-wzwpyvll	619	6	the	the	DT
cord-000372-wzwpyvll	619	7	pioneer	pioneer	JJ
cord-000372-wzwpyvll	619	8	round	round	NN
cord-000372-wzwpyvll	619	9	of	of	IN
cord-000372-wzwpyvll	619	10	translation	translation	NN
cord-000372-wzwpyvll	619	11	in	in	IN
cord-000372-wzwpyvll	619	12	mammalian	mammalian	JJ
cord-000372-wzwpyvll	619	13	cells	cell	NNS
cord-000372-wzwpyvll	619	14	Cleavage	cleavage	NN
cord-000372-wzwpyvll	619	15	of	of	IN
cord-000372-wzwpyvll	619	16	poly(A)-binding	poly(a)-binde	VBG
cord-000372-wzwpyvll	619	17	protein	protein	NN
cord-000372-wzwpyvll	619	18	by	by	IN
cord-000372-wzwpyvll	619	19	enterovirus	enterovirus	NN
cord-000372-wzwpyvll	619	20	proteases	protease	NNS
cord-000372-wzwpyvll	619	21	concurrent	concurrent	JJ
cord-000372-wzwpyvll	619	22	with	with	IN
cord-000372-wzwpyvll	619	23	inhibition	inhibition	NN
cord-000372-wzwpyvll	619	24	of	of	IN
cord-000372-wzwpyvll	619	25	translation	translation	NN
cord-000372-wzwpyvll	619	26	in	in	IN
cord-000372-wzwpyvll	619	27	vitro	vitro	FW
cord-000372-wzwpyvll	619	28	Cleavage	cleavage	NN
cord-000372-wzwpyvll	619	29	of	of	IN
cord-000372-wzwpyvll	619	30	poly(A)-binding	poly(a)-binde	VBG
cord-000372-wzwpyvll	619	31	protein	protein	NN
cord-000372-wzwpyvll	619	32	by	by	IN
cord-000372-wzwpyvll	619	33	coxsackievirus	coxsackievirus	NNP
cord-000372-wzwpyvll	619	34	2A	2a	CD
cord-000372-wzwpyvll	619	35	protease	protease	NN
cord-000372-wzwpyvll	619	36	in	in	IN
cord-000372-wzwpyvll	619	37	vitro	vitro	FW
cord-000372-wzwpyvll	619	38	and	and	CC
cord-000372-wzwpyvll	619	39	in	in	IN
cord-000372-wzwpyvll	619	40	vivo	vivo	NN
cord-000372-wzwpyvll	619	41	:	:	:
cord-000372-wzwpyvll	620	1	another	another	DT
cord-000372-wzwpyvll	620	2	mechanism	mechanism	NN
cord-000372-wzwpyvll	620	3	for	for	IN
cord-000372-wzwpyvll	620	4	host	host	NN
cord-000372-wzwpyvll	620	5	protein	protein	NN
cord-000372-wzwpyvll	620	6	synthesis	synthesis	NN
cord-000372-wzwpyvll	620	7	shutoff	shutoff	NN
cord-000372-wzwpyvll	620	8	?	?	.
cord-000372-wzwpyvll	621	1	Efficient	efficient	JJ
cord-000372-wzwpyvll	621	2	cleavage	cleavage	NN
cord-000372-wzwpyvll	621	3	of	of	IN
cord-000372-wzwpyvll	621	4	ribosome	ribosome	NN
cord-000372-wzwpyvll	621	5	-	-	HYPH
cord-000372-wzwpyvll	621	6	associated	associate	VBN
cord-000372-wzwpyvll	621	7	poly(A)-binding	poly(a)-binding	NN
cord-000372-wzwpyvll	621	8	protein	protein	NN
cord-000372-wzwpyvll	621	9	by	by	IN
cord-000372-wzwpyvll	621	10	enterovirus	enterovirus	NN
cord-000372-wzwpyvll	621	11	3C	3C	NNP
cord-000372-wzwpyvll	621	12	protease	protease	NN
cord-000372-wzwpyvll	621	13	Cleavage	Cleavage	NNP
cord-000372-wzwpyvll	621	14	of	of	IN
cord-000372-wzwpyvll	621	15	poly(A)-binding	poly(a)-binde	VBG
cord-000372-wzwpyvll	621	16	protein	protein	NN
cord-000372-wzwpyvll	621	17	by	by	IN
cord-000372-wzwpyvll	621	18	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	621	19	3C	3C	NNP
cord-000372-wzwpyvll	621	20	protease	protease	NN
cord-000372-wzwpyvll	621	21	inhibits	inhibit	VBZ
cord-000372-wzwpyvll	621	22	host	host	NN
cord-000372-wzwpyvll	621	23	cell	cell	NN
cord-000372-wzwpyvll	621	24	translation	translation	NN
cord-000372-wzwpyvll	621	25	:	:	:
cord-000372-wzwpyvll	621	26	a	a	DT
cord-000372-wzwpyvll	621	27	novel	novel	JJ
cord-000372-wzwpyvll	621	28	mechanism	mechanism	NN
cord-000372-wzwpyvll	621	29	for	for	IN
cord-000372-wzwpyvll	621	30	host	host	NN
cord-000372-wzwpyvll	621	31	translation	translation	NN
cord-000372-wzwpyvll	621	32	shutoff	shutoff	NN
cord-000372-wzwpyvll	621	33	Foot	Foot	NNP
cord-000372-wzwpyvll	621	34	-	-	HYPH
cord-000372-wzwpyvll	621	35	andmouth	andmouth	NNP
cord-000372-wzwpyvll	621	36	disease	disease	NN
cord-000372-wzwpyvll	621	37	virus	virus	NN
cord-000372-wzwpyvll	621	38	leader	leader	NN
cord-000372-wzwpyvll	621	39	proteinase	proteinase	NN
cord-000372-wzwpyvll	621	40	:	:	:
cord-000372-wzwpyvll	621	41	purification	purification	NN
cord-000372-wzwpyvll	621	42	of	of	IN
cord-000372-wzwpyvll	621	43	the	the	DT
cord-000372-wzwpyvll	621	44	Lb	Lb	NNP
cord-000372-wzwpyvll	621	45	form	form	NN
cord-000372-wzwpyvll	621	46	and	and	CC
cord-000372-wzwpyvll	621	47	determination	determination	NN
cord-000372-wzwpyvll	621	48	of	of	IN
cord-000372-wzwpyvll	621	49	its	-PRON-	PRP$
cord-000372-wzwpyvll	621	50	cleavage	cleavage	NN
cord-000372-wzwpyvll	621	51	site	site	NN
cord-000372-wzwpyvll	621	52	on	on	IN
cord-000372-wzwpyvll	621	53	eIF-4γ	eIF-4γ	NNP
cord-000372-wzwpyvll	622	1	Foot	foot	NN
cord-000372-wzwpyvll	622	2	-	-	HYPH
cord-000372-wzwpyvll	622	3	and	and	CC
cord-000372-wzwpyvll	622	4	-	-	HYPH
cord-000372-wzwpyvll	622	5	mouth	mouth	NN
cord-000372-wzwpyvll	622	6	disease	disease	NN
cord-000372-wzwpyvll	622	7	virus	virus	NN
cord-000372-wzwpyvll	623	1	3C	3C	NNP
cord-000372-wzwpyvll	623	2	protease	protease	NNP
cord-000372-wzwpyvll	623	3	induces	induce	VBZ
cord-000372-wzwpyvll	623	4	cleavage	cleavage	NN
cord-000372-wzwpyvll	623	5	of	of	IN
cord-000372-wzwpyvll	623	6	translation	translation	NN
cord-000372-wzwpyvll	623	7	initiation	initiation	NN
cord-000372-wzwpyvll	623	8	factors	factor	NNS
cord-000372-wzwpyvll	623	9	eIF4A	eIF4A	NNS
cord-000372-wzwpyvll	623	10	and	and	CC
cord-000372-wzwpyvll	623	11	eIF4	eIF4	VBZ
cord-000372-wzwpyvll	623	12	G	g	NN
cord-000372-wzwpyvll	623	13	within	within	IN
cord-000372-wzwpyvll	623	14	infected	infected	JJ
cord-000372-wzwpyvll	623	15	cells	cell	NNS
cord-000372-wzwpyvll	623	16	Cleavage	cleavage	NN
cord-000372-wzwpyvll	623	17	of	of	IN
cord-000372-wzwpyvll	623	18	eukaryotic	eukaryotic	JJ
cord-000372-wzwpyvll	623	19	translation	translation	NN
cord-000372-wzwpyvll	623	20	initiation	initiation	NN
cord-000372-wzwpyvll	623	21	factor	factor	NN
cord-000372-wzwpyvll	623	22	4GII	4gii	CD
cord-000372-wzwpyvll	623	23	within	within	IN
cord-000372-wzwpyvll	623	24	foot	foot	NN
cord-000372-wzwpyvll	623	25	-	-	HYPH
cord-000372-wzwpyvll	623	26	and	and	CC
cord-000372-wzwpyvll	623	27	-	-	HYPH
cord-000372-wzwpyvll	623	28	mouth	mouth	NN
cord-000372-wzwpyvll	623	29	disease	disease	NN
cord-000372-wzwpyvll	623	30	virus	virus	NN
cord-000372-wzwpyvll	623	31	-	-	HYPH
cord-000372-wzwpyvll	623	32	infected	infect	VBN
cord-000372-wzwpyvll	623	33	cells	cell	NNS
cord-000372-wzwpyvll	623	34	:	:	:
cord-000372-wzwpyvll	623	35	identification	identification	NN
cord-000372-wzwpyvll	623	36	of	of	IN
cord-000372-wzwpyvll	623	37	the	the	DT
cord-000372-wzwpyvll	623	38	L	l	NN
cord-000372-wzwpyvll	623	39	-	-	HYPH
cord-000372-wzwpyvll	623	40	protease	protease	NN
cord-000372-wzwpyvll	623	41	cleavage	cleavage	NN
cord-000372-wzwpyvll	623	42	site	site	NN
cord-000372-wzwpyvll	623	43	in	in	IN
cord-000372-wzwpyvll	623	44	vitro	vitro	FW
cord-000372-wzwpyvll	623	45	Sequential	sequential	JJ
cord-000372-wzwpyvll	623	46	modification	modification	NN
cord-000372-wzwpyvll	623	47	of	of	IN
cord-000372-wzwpyvll	623	48	translation	translation	NN
cord-000372-wzwpyvll	623	49	initiation	initiation	NN
cord-000372-wzwpyvll	623	50	factor	factor	NN
cord-000372-wzwpyvll	623	51	elF4Gl	elf4gl	RB
cord-000372-wzwpyvll	623	52	by	by	IN
cord-000372-wzwpyvll	623	53	two	two	CD
cord-000372-wzwpyvll	623	54	different	different	JJ
cord-000372-wzwpyvll	623	55	foot	foot	NN
cord-000372-wzwpyvll	623	56	-	-	HYPH
cord-000372-wzwpyvll	623	57	andmouth	andmouth	NNP
cord-000372-wzwpyvll	623	58	disease	disease	NN
cord-000372-wzwpyvll	623	59	virus	virus	NN
cord-000372-wzwpyvll	623	60	proteases	protease	NNS
cord-000372-wzwpyvll	623	61	within	within	IN
cord-000372-wzwpyvll	623	62	infected	infected	JJ
cord-000372-wzwpyvll	623	63	baby	baby	NN
cord-000372-wzwpyvll	623	64	hamster	hamster	NN
cord-000372-wzwpyvll	623	65	kidney	kidney	NN
cord-000372-wzwpyvll	623	66	cells	cell	NNS
cord-000372-wzwpyvll	623	67	:	:	:
cord-000372-wzwpyvll	623	68	identification	identification	NN
cord-000372-wzwpyvll	623	69	of	of	IN
cord-000372-wzwpyvll	623	70	the	the	DT
cord-000372-wzwpyvll	623	71	3C	3C	NNP
cord-000372-wzwpyvll	623	72	cleavage	cleavage	NN
cord-000372-wzwpyvll	623	73	site	site	NN
cord-000372-wzwpyvll	623	74	Conducting	conduct	VBG
cord-000372-wzwpyvll	623	75	the	the	DT
cord-000372-wzwpyvll	623	76	initiation	initiation	NN
cord-000372-wzwpyvll	623	77	of	of	IN
cord-000372-wzwpyvll	623	78	protein	protein	NN
cord-000372-wzwpyvll	623	79	synthesis	synthesis	NN
cord-000372-wzwpyvll	623	80	:	:	:
cord-000372-wzwpyvll	624	1	the	the	DT
cord-000372-wzwpyvll	624	2	role	role	NN
cord-000372-wzwpyvll	624	3	of	of	IN
cord-000372-wzwpyvll	624	4	eIF4	eIF4	NNP
cord-000372-wzwpyvll	624	5	G	G	NNP
cord-000372-wzwpyvll	624	6	HIV-1	HIV-1	NNP
cord-000372-wzwpyvll	624	7	protease	protease	NN
cord-000372-wzwpyvll	624	8	cleaves	cleave	VBZ
cord-000372-wzwpyvll	624	9	eukaryotic	eukaryotic	JJ
cord-000372-wzwpyvll	624	10	initiation	initiation	NN
cord-000372-wzwpyvll	624	11	factor	factor	NN
cord-000372-wzwpyvll	624	12	4	4	CD
cord-000372-wzwpyvll	624	13	G	g	NN
cord-000372-wzwpyvll	624	14	and	and	CC
cord-000372-wzwpyvll	624	15	inhibits	inhibit	VBZ
cord-000372-wzwpyvll	624	16	cap	cap	NN
cord-000372-wzwpyvll	624	17	-	-	HYPH
cord-000372-wzwpyvll	624	18	dependent	dependent	JJ
cord-000372-wzwpyvll	624	19	translation	translation	NN
cord-000372-wzwpyvll	625	1	In	in	IN
cord-000372-wzwpyvll	625	2	vitro	vitro	FW
cord-000372-wzwpyvll	625	3	cleavage	cleavage	NN
cord-000372-wzwpyvll	625	4	of	of	IN
cord-000372-wzwpyvll	625	5	eIF4GI	eIF4GI	NNS
cord-000372-wzwpyvll	625	6	but	but	CC
cord-000372-wzwpyvll	625	7	not	not	RB
cord-000372-wzwpyvll	625	8	eIF4GII	eIF4GII	VBZ
cord-000372-wzwpyvll	625	9	by	by	IN
cord-000372-wzwpyvll	625	10	HIV-1	HIV-1	NNP
cord-000372-wzwpyvll	625	11	protease	protease	NN
cord-000372-wzwpyvll	625	12	and	and	CC
cord-000372-wzwpyvll	625	13	its	-PRON-	PRP$
cord-000372-wzwpyvll	625	14	effects	effect	NNS
cord-000372-wzwpyvll	625	15	on	on	IN
cord-000372-wzwpyvll	625	16	translation	translation	NN
cord-000372-wzwpyvll	625	17	in	in	IN
cord-000372-wzwpyvll	625	18	the	the	DT
cord-000372-wzwpyvll	625	19	rabbit	rabbit	NN
cord-000372-wzwpyvll	625	20	reticulocyte	reticulocyte	NNP
cord-000372-wzwpyvll	625	21	lysate	lysate	NN
cord-000372-wzwpyvll	625	22	system	system	NN
cord-000372-wzwpyvll	625	23	Cleavage	cleavage	NN
cord-000372-wzwpyvll	625	24	of	of	IN
cord-000372-wzwpyvll	625	25	eIF4	eIF4	NNP
cord-000372-wzwpyvll	625	26	G	G	NNP
cord-000372-wzwpyvll	625	27	by	by	IN
cord-000372-wzwpyvll	625	28	HIV-1	HIV-1	NNP
cord-000372-wzwpyvll	625	29	protease	protease	NN
cord-000372-wzwpyvll	625	30	:	:	:
cord-000372-wzwpyvll	625	31	effects	effect	NNS
cord-000372-wzwpyvll	625	32	on	on	IN
cord-000372-wzwpyvll	625	33	translation	translation	NN
cord-000372-wzwpyvll	625	34	HIV	HIV	NNP
cord-000372-wzwpyvll	625	35	protease	protease	NN
cord-000372-wzwpyvll	625	36	cleaves	cleave	VBZ
cord-000372-wzwpyvll	625	37	poly(A)-binding	poly(a)-binde	VBG
cord-000372-wzwpyvll	625	38	protein	protein	NN
cord-000372-wzwpyvll	625	39	Cap	cap	NN
cord-000372-wzwpyvll	625	40	-	-	HYPH
cord-000372-wzwpyvll	625	41	poly(A	poly(A	NNP
cord-000372-wzwpyvll	625	42	)	)	-RRB-
cord-000372-wzwpyvll	625	43	synergy	synergy	NN
cord-000372-wzwpyvll	625	44	in	in	IN
cord-000372-wzwpyvll	625	45	mammalian	mammalian	JJ
cord-000372-wzwpyvll	625	46	cellfree	cellfree	NNP
cord-000372-wzwpyvll	625	47	extracts	extract	NNS
cord-000372-wzwpyvll	625	48	.	.	.
cord-000372-wzwpyvll	626	1	Investigation	investigation	NN
cord-000372-wzwpyvll	626	2	of	of	IN
cord-000372-wzwpyvll	626	3	the	the	DT
cord-000372-wzwpyvll	626	4	requirements	requirement	NNS
cord-000372-wzwpyvll	626	5	for	for	IN
cord-000372-wzwpyvll	626	6	poly(A)-mediated	poly(a)-mediated	JJ
cord-000372-wzwpyvll	626	7	stimulation	stimulation	NN
cord-000372-wzwpyvll	626	8	of	of	IN
cord-000372-wzwpyvll	626	9	translation	translation	NN
cord-000372-wzwpyvll	626	10	initiation	initiation	NN
cord-000372-wzwpyvll	626	11	Characterization	characterization	NN
cord-000372-wzwpyvll	626	12	of	of	IN
cord-000372-wzwpyvll	626	13	an	an	DT
cord-000372-wzwpyvll	626	14	internal	internal	JJ
cord-000372-wzwpyvll	626	15	ribosomal	ribosomal	NN
cord-000372-wzwpyvll	626	16	entry	entry	NN
cord-000372-wzwpyvll	626	17	segment	segment	NN
cord-000372-wzwpyvll	626	18	within	within	IN
cord-000372-wzwpyvll	626	19	the	the	DT
cord-000372-wzwpyvll	626	20	5	5	CD
cord-000372-wzwpyvll	626	21	'	'	POS
cord-000372-wzwpyvll	626	22	leader	leader	NN
cord-000372-wzwpyvll	626	23	of	of	IN
cord-000372-wzwpyvll	626	24	avian	avian	JJ
cord-000372-wzwpyvll	626	25	reticuloendotheliosis	reticuloendotheliosis	NNP
cord-000372-wzwpyvll	626	26	virus	virus	NN
cord-000372-wzwpyvll	626	27	type	type	NN
cord-000372-wzwpyvll	626	28	A	a	DT
cord-000372-wzwpyvll	626	29	RNA	rna	NN
cord-000372-wzwpyvll	626	30	and	and	CC
cord-000372-wzwpyvll	626	31	development	development	NN
cord-000372-wzwpyvll	626	32	of	of	IN
cord-000372-wzwpyvll	626	33	novel	novel	JJ
cord-000372-wzwpyvll	626	34	MLV	MLV	NNP
cord-000372-wzwpyvll	626	35	-	-	HYPH
cord-000372-wzwpyvll	626	36	REV	REV	NNP
cord-000372-wzwpyvll	626	37	-	-	HYPH
cord-000372-wzwpyvll	626	38	Based	base	VBN
cord-000372-wzwpyvll	626	39	retroviral	retroviral	NN
cord-000372-wzwpyvll	626	40	vectors	vector	NNS
cord-000372-wzwpyvll	627	1	An	an	DT
cord-000372-wzwpyvll	627	2	internal	internal	JJ
cord-000372-wzwpyvll	627	3	ribosome	ribosome	NN
cord-000372-wzwpyvll	627	4	entry	entry	NN
cord-000372-wzwpyvll	627	5	segment	segment	NN
cord-000372-wzwpyvll	627	6	promotes	promote	VBZ
cord-000372-wzwpyvll	627	7	translation	translation	NN
cord-000372-wzwpyvll	627	8	of	of	IN
cord-000372-wzwpyvll	627	9	the	the	DT
cord-000372-wzwpyvll	627	10	simian	simian	JJ
cord-000372-wzwpyvll	627	11	immunodeficiency	immunodeficiency	NN
cord-000372-wzwpyvll	627	12	virus	virus	NN
cord-000372-wzwpyvll	627	13	genomic	genomic	JJ
cord-000372-wzwpyvll	627	14	RNA	RNA	NNP
cord-000372-wzwpyvll	628	1	The	the	DT
cord-000372-wzwpyvll	628	2	leader	leader	NN
cord-000372-wzwpyvll	628	3	of	of	IN
cord-000372-wzwpyvll	628	4	human	human	JJ
cord-000372-wzwpyvll	628	5	immunodeficiency	immunodeficiency	NN
cord-000372-wzwpyvll	628	6	virus	virus	NN
cord-000372-wzwpyvll	628	7	type	type	NN
cord-000372-wzwpyvll	628	8	1	1	CD
cord-000372-wzwpyvll	628	9	genomic	genomic	JJ
cord-000372-wzwpyvll	628	10	RNA	RNA	NNP
cord-000372-wzwpyvll	628	11	harbors	harbor	VBZ
cord-000372-wzwpyvll	628	12	an	an	DT
cord-000372-wzwpyvll	628	13	internal	internal	JJ
cord-000372-wzwpyvll	628	14	ribosome	ribosome	NN
cord-000372-wzwpyvll	628	15	entry	entry	NN
cord-000372-wzwpyvll	628	16	segment	segment	NN
cord-000372-wzwpyvll	628	17	that	that	WDT
cord-000372-wzwpyvll	628	18	is	be	VBZ
cord-000372-wzwpyvll	628	19	active	active	JJ
cord-000372-wzwpyvll	628	20	during	during	IN
cord-000372-wzwpyvll	628	21	the	the	DT
cord-000372-wzwpyvll	628	22	G	G	NNP
cord-000372-wzwpyvll	628	23	/	/	SYM
cord-000372-wzwpyvll	628	24	M	M	NNP
cord-000372-wzwpyvll	628	25	phase	phase	NN
cord-000372-wzwpyvll	628	26	of	of	IN
cord-000372-wzwpyvll	628	27	the	the	DT
cord-000372-wzwpyvll	628	28	cell	cell	NN
cord-000372-wzwpyvll	628	29	cycle	cycle	NN
cord-000372-wzwpyvll	628	30	Cleavage	cleavage	NN
cord-000372-wzwpyvll	628	31	of	of	IN
cord-000372-wzwpyvll	628	32	eukaryotic	eukaryotic	JJ
cord-000372-wzwpyvll	628	33	initiation	initiation	NN
cord-000372-wzwpyvll	628	34	factor	factor	NN
cord-000372-wzwpyvll	628	35	elF4	elf4	JJ
cord-000372-wzwpyvll	628	36	G	g	NN
cord-000372-wzwpyvll	628	37	and	and	CC
cord-000372-wzwpyvll	628	38	inhibition	inhibition	NN
cord-000372-wzwpyvll	628	39	of	of	IN
cord-000372-wzwpyvll	628	40	host	host	NN
cord-000372-wzwpyvll	628	41	-	-	HYPH
cord-000372-wzwpyvll	628	42	cell	cell	NN
cord-000372-wzwpyvll	628	43	protein	protein	NN
cord-000372-wzwpyvll	628	44	synthesis	synthesis	NN
cord-000372-wzwpyvll	628	45	during	during	IN
cord-000372-wzwpyvll	628	46	feline	feline	JJ
cord-000372-wzwpyvll	628	47	calicivirus	calicivirus	NNP
cord-000372-wzwpyvll	628	48	infection	infection	NN
cord-000372-wzwpyvll	629	1	Calicivirus	Calicivirus	NNP
cord-000372-wzwpyvll	629	2	3C	3c	NN
cord-000372-wzwpyvll	629	3	-	-	HYPH
cord-000372-wzwpyvll	629	4	like	like	JJ
cord-000372-wzwpyvll	630	1	proteinase	proteinase	NN
cord-000372-wzwpyvll	630	2	inhibits	inhibit	VBZ
cord-000372-wzwpyvll	630	3	cellular	cellular	JJ
cord-000372-wzwpyvll	630	4	translation	translation	NN
cord-000372-wzwpyvll	630	5	by	by	IN
cord-000372-wzwpyvll	630	6	cleavage	cleavage	NN
cord-000372-wzwpyvll	630	7	of	of	IN
cord-000372-wzwpyvll	630	8	poly(A)-binding	poly(A)-binding	NNP
cord-000372-wzwpyvll	630	9	protein	protein	NN
cord-000372-wzwpyvll	630	10	Inhibition	Inhibition	NNP
cord-000372-wzwpyvll	630	11	of	of	IN
cord-000372-wzwpyvll	630	12	nuclear	nuclear	JJ
cord-000372-wzwpyvll	630	13	import	import	NN
cord-000372-wzwpyvll	630	14	and	and	CC
cord-000372-wzwpyvll	630	15	alteration	alteration	NN
cord-000372-wzwpyvll	630	16	of	of	IN
cord-000372-wzwpyvll	630	17	nuclear	nuclear	JJ
cord-000372-wzwpyvll	630	18	pore	pore	NN
cord-000372-wzwpyvll	630	19	complex	complex	JJ
cord-000372-wzwpyvll	630	20	composition	composition	NN
cord-000372-wzwpyvll	630	21	by	by	IN
cord-000372-wzwpyvll	630	22	rhinovirus	rhinovirus	NN
cord-000372-wzwpyvll	630	23	Leader	Leader	NNP
cord-000372-wzwpyvll	630	24	-	-	HYPH
cord-000372-wzwpyvll	630	25	induced	induce	VBN
cord-000372-wzwpyvll	630	26	phosphorylation	phosphorylation	NN
cord-000372-wzwpyvll	630	27	of	of	IN
cord-000372-wzwpyvll	630	28	nucleoporins	nucleoporin	NNS
cord-000372-wzwpyvll	630	29	correlates	correlate	VBZ
cord-000372-wzwpyvll	630	30	with	with	IN
cord-000372-wzwpyvll	630	31	nuclear	nuclear	JJ
cord-000372-wzwpyvll	630	32	trafficking	trafficking	NN
cord-000372-wzwpyvll	630	33	inhibition	inhibition	NN
cord-000372-wzwpyvll	630	34	by	by	IN
cord-000372-wzwpyvll	630	35	cardioviruses	cardioviruses	NNP
cord-000372-wzwpyvll	630	36	Vesicular	Vesicular	NNP
cord-000372-wzwpyvll	630	37	stomatitis	stomatitis	NN
cord-000372-wzwpyvll	630	38	virus	virus	NN
cord-000372-wzwpyvll	630	39	matrix	matrix	NN
cord-000372-wzwpyvll	630	40	protein	protein	NN
cord-000372-wzwpyvll	631	1	inhibits	inhibit	VBZ
cord-000372-wzwpyvll	631	2	host	host	NN
cord-000372-wzwpyvll	631	3	cell	cell	NN
cord-000372-wzwpyvll	631	4	gene	gene	NN
cord-000372-wzwpyvll	631	5	expression	expression	NN
cord-000372-wzwpyvll	631	6	by	by	IN
cord-000372-wzwpyvll	631	7	targeting	target	VBG
cord-000372-wzwpyvll	631	8	the	the	DT
cord-000372-wzwpyvll	631	9	nucleoporin	nucleoporin	NNP
cord-000372-wzwpyvll	631	10	Nup98	Nup98	NNP
cord-000372-wzwpyvll	631	11	Influenza	Influenza	NNP
cord-000372-wzwpyvll	631	12	virus	virus	NN
cord-000372-wzwpyvll	631	13	targets	target	VBZ
cord-000372-wzwpyvll	631	14	the	the	DT
cord-000372-wzwpyvll	631	15	mRNA	mRNA	NNP
cord-000372-wzwpyvll	631	16	export	export	NN
cord-000372-wzwpyvll	631	17	machinery	machinery	NN
cord-000372-wzwpyvll	631	18	and	and	CC
cord-000372-wzwpyvll	631	19	the	the	DT
cord-000372-wzwpyvll	631	20	nuclear	nuclear	JJ
cord-000372-wzwpyvll	631	21	pore	pore	NN
cord-000372-wzwpyvll	631	22	complex	complex	NN
cord-000372-wzwpyvll	631	23	Exporting	Exporting	NNP
cord-000372-wzwpyvll	631	24	RNA	RNA	NNP
cord-000372-wzwpyvll	631	25	from	from	IN
cord-000372-wzwpyvll	631	26	the	the	DT
cord-000372-wzwpyvll	631	27	nucleus	nucleus	NN
cord-000372-wzwpyvll	631	28	to	to	IN
cord-000372-wzwpyvll	631	29	the	the	DT
cord-000372-wzwpyvll	631	30	cytoplasm	cytoplasm	NN
cord-000372-wzwpyvll	632	1	Crossing	cross	VBG
cord-000372-wzwpyvll	632	2	the	the	DT
cord-000372-wzwpyvll	632	3	nuclear	nuclear	JJ
cord-000372-wzwpyvll	632	4	envelope	envelope	NN
cord-000372-wzwpyvll	632	5	:	:	:
cord-000372-wzwpyvll	632	6	hierarchical	hierarchical	JJ
cord-000372-wzwpyvll	632	7	regulation	regulation	NN
cord-000372-wzwpyvll	632	8	of	of	IN
cord-000372-wzwpyvll	632	9	nucleocytoplasmic	nucleocytoplasmic	NNP
cord-000372-wzwpyvll	632	10	transport	transport	NN
cord-000372-wzwpyvll	633	1	The	the	DT
cord-000372-wzwpyvll	633	2	yeast	yeast	NN
cord-000372-wzwpyvll	633	3	nuclear	nuclear	JJ
cord-000372-wzwpyvll	633	4	pore	pore	NN
cord-000372-wzwpyvll	633	5	complex	complex	NN
cord-000372-wzwpyvll	633	6	:	:	:
cord-000372-wzwpyvll	633	7	composition	composition	NN
cord-000372-wzwpyvll	633	8	,	,	,
cord-000372-wzwpyvll	633	9	architecture	architecture	NN
cord-000372-wzwpyvll	633	10	,	,	,
cord-000372-wzwpyvll	633	11	transport	transport	NN
cord-000372-wzwpyvll	633	12	mechanism	mechanism	NN
cord-000372-wzwpyvll	634	1	Proteomic	proteomic	JJ
cord-000372-wzwpyvll	634	2	analysis	analysis	NN
cord-000372-wzwpyvll	634	3	of	of	IN
cord-000372-wzwpyvll	634	4	the	the	DT
cord-000372-wzwpyvll	634	5	mammalian	mammalian	JJ
cord-000372-wzwpyvll	634	6	nuclear	nuclear	JJ
cord-000372-wzwpyvll	634	7	pore	pore	NN
cord-000372-wzwpyvll	634	8	complex	complex	NN
cord-000372-wzwpyvll	635	1	The	the	DT
cord-000372-wzwpyvll	635	2	Part	Part	NNP
cord-000372-wzwpyvll	635	3	and	and	CC
cord-000372-wzwpyvll	635	4	the	the	DT
cord-000372-wzwpyvll	635	5	Whole	whole	NN
cord-000372-wzwpyvll	635	6	:	:	:
cord-000372-wzwpyvll	635	7	functions	function	NNS
cord-000372-wzwpyvll	635	8	of	of	IN
cord-000372-wzwpyvll	635	9	nucleoporins	nucleoporin	NNS
cord-000372-wzwpyvll	635	10	in	in	IN
cord-000372-wzwpyvll	635	11	nucleocytoplasmic	nucleocytoplasmic	NNP
cord-000372-wzwpyvll	635	12	transport	transport	NN
cord-000372-wzwpyvll	635	13	Nuclear	nuclear	JJ
cord-000372-wzwpyvll	635	14	pore	pore	NN
cord-000372-wzwpyvll	635	15	complex	complex	NN
cord-000372-wzwpyvll	635	16	is	be	VBZ
cord-000372-wzwpyvll	635	17	able	able	JJ
cord-000372-wzwpyvll	635	18	to	to	TO
cord-000372-wzwpyvll	635	19	transport	transport	VB
cord-000372-wzwpyvll	635	20	macromolecules	macromolecule	NNS
cord-000372-wzwpyvll	635	21	with	with	IN
cord-000372-wzwpyvll	635	22	diameters	diameter	NNS
cord-000372-wzwpyvll	635	23	of	of	IN
cord-000372-wzwpyvll	635	24	about	about	RB
cord-000372-wzwpyvll	635	25	39	39	CD
cord-000372-wzwpyvll	635	26	nm	nm	NNP
cord-000372-wzwpyvll	635	27	Nucleocytoplasmic	Nucleocytoplasmic	NNP
cord-000372-wzwpyvll	635	28	transport	transport	NN
cord-000372-wzwpyvll	635	29	:	:	:
cord-000372-wzwpyvll	635	30	taking	take	VBG
cord-000372-wzwpyvll	635	31	an	an	DT
cord-000372-wzwpyvll	635	32	inventory	inventory	NN
cord-000372-wzwpyvll	636	1	The	the	DT
cord-000372-wzwpyvll	636	2	nuclear	nuclear	JJ
cord-000372-wzwpyvll	636	3	pore	pore	NN
cord-000372-wzwpyvll	636	4	complex	complex	NN
cord-000372-wzwpyvll	636	5	:	:	:
cord-000372-wzwpyvll	636	6	bridging	bridge	VBG
cord-000372-wzwpyvll	636	7	nuclear	nuclear	JJ
cord-000372-wzwpyvll	636	8	transport	transport	NN
cord-000372-wzwpyvll	636	9	and	and	CC
cord-000372-wzwpyvll	636	10	gene	gene	NN
cord-000372-wzwpyvll	636	11	regulation	regulation	NN
cord-000372-wzwpyvll	636	12	Nuclear	nuclear	JJ
cord-000372-wzwpyvll	636	13	localization	localization	NN
cord-000372-wzwpyvll	636	14	signal	signal	NN
cord-000372-wzwpyvll	636	15	and	and	CC
cord-000372-wzwpyvll	636	16	protein	protein	NN
cord-000372-wzwpyvll	636	17	context	context	NN
cord-000372-wzwpyvll	636	18	both	both	DT
cord-000372-wzwpyvll	636	19	mediate	mediate	VBP
cord-000372-wzwpyvll	636	20	importin	importin	NNP
cord-000372-wzwpyvll	637	1	α	α	NN
cord-000372-wzwpyvll	637	2	specificity	specificity	NN
cord-000372-wzwpyvll	637	3	of	of	IN
cord-000372-wzwpyvll	637	4	nuclear	nuclear	JJ
cord-000372-wzwpyvll	637	5	import	import	NN
cord-000372-wzwpyvll	637	6	substrates	substrate	NNS
cord-000372-wzwpyvll	637	7	Regulation	Regulation	NNP
cord-000372-wzwpyvll	637	8	of	of	IN
cord-000372-wzwpyvll	637	9	nuclear	nuclear	JJ
cord-000372-wzwpyvll	637	10	transport	transport	NN
cord-000372-wzwpyvll	637	11	:	:	:
cord-000372-wzwpyvll	637	12	central	central	JJ
cord-000372-wzwpyvll	637	13	role	role	NN
cord-000372-wzwpyvll	637	14	in	in	IN
cord-000372-wzwpyvll	637	15	development	development	NN
cord-000372-wzwpyvll	637	16	and	and	CC
cord-000372-wzwpyvll	637	17	transformation	transformation	NN
cord-000372-wzwpyvll	637	18	Inhibition	inhibition	NN
cord-000372-wzwpyvll	637	19	of	of	IN
cord-000372-wzwpyvll	637	20	Crm1-p53	Crm1-p53	NNP
cord-000372-wzwpyvll	637	21	interaction	interaction	NN
cord-000372-wzwpyvll	637	22	and	and	CC
cord-000372-wzwpyvll	637	23	nuclear	nuclear	JJ
cord-000372-wzwpyvll	637	24	export	export	NN
cord-000372-wzwpyvll	637	25	of	of	IN
cord-000372-wzwpyvll	637	26	p53	p53	NN
cord-000372-wzwpyvll	637	27	by	by	IN
cord-000372-wzwpyvll	637	28	poly(ADP	poly(ADP	NNP
cord-000372-wzwpyvll	637	29	-	-	HYPH
cord-000372-wzwpyvll	637	30	ribosyl)ation	ribosyl)ation	NNP
cord-000372-wzwpyvll	637	31	Arginine	arginine	NN
cord-000372-wzwpyvll	637	32	methylation	methylation	NN
cord-000372-wzwpyvll	637	33	of	of	IN
cord-000372-wzwpyvll	637	34	RNA	RNA	NNP
cord-000372-wzwpyvll	638	1	helicase	helicase	NNP
cord-000372-wzwpyvll	639	1	A	a	DT
cord-000372-wzwpyvll	639	2	determines	determine	VBZ
cord-000372-wzwpyvll	639	3	its	-PRON-	PRP$
cord-000372-wzwpyvll	639	4	subcellular	subcellular	JJ
cord-000372-wzwpyvll	639	5	localization	localization	NN
cord-000372-wzwpyvll	639	6	Identification	identification	NN
cord-000372-wzwpyvll	639	7	of	of	IN
cord-000372-wzwpyvll	639	8	a	a	DT
cord-000372-wzwpyvll	639	9	tRNA	trna	NN
cord-000372-wzwpyvll	639	10	-	-	HYPH
cord-000372-wzwpyvll	639	11	specific	specific	JJ
cord-000372-wzwpyvll	639	12	nuclear	nuclear	JJ
cord-000372-wzwpyvll	639	13	export	export	NN
cord-000372-wzwpyvll	639	14	receptor	receptor	NN
cord-000372-wzwpyvll	639	15	Identification	identification	NN
cord-000372-wzwpyvll	639	16	of	of	IN
cord-000372-wzwpyvll	639	17	a	a	DT
cord-000372-wzwpyvll	639	18	nuclear	nuclear	JJ
cord-000372-wzwpyvll	639	19	export	export	NN
cord-000372-wzwpyvll	639	20	receptor	receptor	NN
cord-000372-wzwpyvll	639	21	for	for	IN
cord-000372-wzwpyvll	639	22	tRNA	tRNA	NNP
cord-000372-wzwpyvll	639	23	Exportin-5-mediated	exportin-5-mediate	VBN
cord-000372-wzwpyvll	639	24	nuclear	nuclear	JJ
cord-000372-wzwpyvll	639	25	export	export	NN
cord-000372-wzwpyvll	639	26	of	of	IN
cord-000372-wzwpyvll	639	27	eukaryotic	eukaryotic	JJ
cord-000372-wzwpyvll	639	28	elongation	elongation	NN
cord-000372-wzwpyvll	639	29	factor	factor	NN
cord-000372-wzwpyvll	639	30	1A	1a	NN
cord-000372-wzwpyvll	639	31	and	and	CC
cord-000372-wzwpyvll	639	32	tRNA	tRNA	NNP
cord-000372-wzwpyvll	639	33	PHAX	PHAX	NNP
cord-000372-wzwpyvll	639	34	,	,	,
cord-000372-wzwpyvll	639	35	a	a	DT
cord-000372-wzwpyvll	639	36	mediator	mediator	NN
cord-000372-wzwpyvll	639	37	of	of	IN
cord-000372-wzwpyvll	639	38	U	U	NNP
cord-000372-wzwpyvll	639	39	snRNA	snRNA	NNP
cord-000372-wzwpyvll	639	40	nuclear	nuclear	JJ
cord-000372-wzwpyvll	639	41	export	export	NN
cord-000372-wzwpyvll	639	42	whose	whose	WP$
cord-000372-wzwpyvll	639	43	activity	activity	NN
cord-000372-wzwpyvll	639	44	is	be	VBZ
cord-000372-wzwpyvll	639	45	regulated	regulate	VBN
cord-000372-wzwpyvll	639	46	by	by	IN
cord-000372-wzwpyvll	639	47	phosphorylation	phosphorylation	NN
cord-000372-wzwpyvll	639	48	Nmd3p	nmd3p	PRP
cord-000372-wzwpyvll	639	49	is	be	VBZ
cord-000372-wzwpyvll	639	50	a	a	DT
cord-000372-wzwpyvll	639	51	Crm1p	Crm1p	NNP
cord-000372-wzwpyvll	639	52	-	-	HYPH
cord-000372-wzwpyvll	639	53	dependent	dependent	JJ
cord-000372-wzwpyvll	639	54	adapter	adapter	NN
cord-000372-wzwpyvll	639	55	protein	protein	NN
cord-000372-wzwpyvll	639	56	for	for	IN
cord-000372-wzwpyvll	639	57	nuclear	nuclear	JJ
cord-000372-wzwpyvll	639	58	export	export	NN
cord-000372-wzwpyvll	639	59	of	of	IN
cord-000372-wzwpyvll	639	60	the	the	DT
cord-000372-wzwpyvll	639	61	large	large	JJ
cord-000372-wzwpyvll	639	62	ribosomal	ribosomal	JJ
cord-000372-wzwpyvll	639	63	subunit	subunit	NN
cord-000372-wzwpyvll	639	64	60S	60s	CD
cord-000372-wzwpyvll	639	65	pre	pre	JJ
cord-000372-wzwpyvll	639	66	-	-	JJ
cord-000372-wzwpyvll	639	67	ribosome	ribosome	JJ
cord-000372-wzwpyvll	639	68	formation	formation	NN
cord-000372-wzwpyvll	639	69	viewed	view	VBN
cord-000372-wzwpyvll	639	70	from	from	IN
cord-000372-wzwpyvll	639	71	assembly	assembly	NN
cord-000372-wzwpyvll	639	72	in	in	IN
cord-000372-wzwpyvll	639	73	the	the	DT
cord-000372-wzwpyvll	639	74	nucleolus	nucleolus	NN
cord-000372-wzwpyvll	639	75	until	until	IN
cord-000372-wzwpyvll	639	76	export	export	NN
cord-000372-wzwpyvll	639	77	to	to	IN
cord-000372-wzwpyvll	639	78	the	the	DT
cord-000372-wzwpyvll	639	79	cytoplasm	cytoplasm	JJ
cord-000372-wzwpyvll	639	80	Release	Release	NNP
cord-000372-wzwpyvll	639	81	of	of	IN
cord-000372-wzwpyvll	639	82	the	the	DT
cord-000372-wzwpyvll	639	83	export	export	NN
cord-000372-wzwpyvll	639	84	adapter	adapter	NN
cord-000372-wzwpyvll	639	85	,	,	,
cord-000372-wzwpyvll	639	86	Nmd3p	Nmd3p	NNP
cord-000372-wzwpyvll	639	87	,	,	,
cord-000372-wzwpyvll	639	88	from	from	IN
cord-000372-wzwpyvll	639	89	the	the	DT
cord-000372-wzwpyvll	639	90	60S	60s	CD
cord-000372-wzwpyvll	639	91	ribosomal	ribosomal	JJ
cord-000372-wzwpyvll	639	92	subunit	subunit	NN
cord-000372-wzwpyvll	639	93	requires	require	VBZ
cord-000372-wzwpyvll	639	94	Rpl10p	Rpl10p	NNP
cord-000372-wzwpyvll	639	95	and	and	CC
cord-000372-wzwpyvll	639	96	the	the	DT
cord-000372-wzwpyvll	639	97	cytoplasmic	cytoplasmic	JJ
cord-000372-wzwpyvll	639	98	GTPase	GTPase	NNP
cord-000372-wzwpyvll	639	99	Lsg1p	Lsg1p	NNP
cord-000372-wzwpyvll	639	100	Human	Human	NNP
cord-000372-wzwpyvll	639	101	mRNA	mRNA	NNP
cord-000372-wzwpyvll	639	102	export	export	NN
cord-000372-wzwpyvll	639	103	machinery	machinery	NN
cord-000372-wzwpyvll	639	104	recruited	recruit	VBN
cord-000372-wzwpyvll	639	105	to	to	IN
cord-000372-wzwpyvll	639	106	the	the	DT
cord-000372-wzwpyvll	639	107	5	5	CD
cord-000372-wzwpyvll	639	108	'	'	NN
cord-000372-wzwpyvll	639	109	end	end	NN
cord-000372-wzwpyvll	639	110	of	of	IN
cord-000372-wzwpyvll	639	111	mRNA	mRNA	NNP
cord-000372-wzwpyvll	639	112	Splicing	splicing	NN
cord-000372-wzwpyvll	639	113	factor	factor	NN
cord-000372-wzwpyvll	639	114	Sub2p	sub2p	NN
cord-000372-wzwpyvll	639	115	is	be	VBZ
cord-000372-wzwpyvll	639	116	required	require	VBN
cord-000372-wzwpyvll	639	117	for	for	IN
cord-000372-wzwpyvll	639	118	nuclear	nuclear	JJ
cord-000372-wzwpyvll	639	119	mRNA	mRNA	NNP
cord-000372-wzwpyvll	639	120	export	export	NN
cord-000372-wzwpyvll	639	121	through	through	IN
cord-000372-wzwpyvll	639	122	its	-PRON-	PRP$
cord-000372-wzwpyvll	639	123	interaction	interaction	NN
cord-000372-wzwpyvll	639	124	with	with	IN
cord-000372-wzwpyvll	639	125	Yra1p	yra1p	NN
cord-000372-wzwpyvll	640	1	The	the	DT
cord-000372-wzwpyvll	640	2	exon	exon	NN
cord-000372-wzwpyvll	640	3	-	-	HYPH
cord-000372-wzwpyvll	640	4	exon	exon	JJ
cord-000372-wzwpyvll	640	5	junction	junction	NN
cord-000372-wzwpyvll	640	6	complex	complex	NN
cord-000372-wzwpyvll	640	7	provides	provide	VBZ
cord-000372-wzwpyvll	640	8	a	a	DT
cord-000372-wzwpyvll	640	9	binding	bind	VBG
cord-000372-wzwpyvll	640	10	platform	platform	NN
cord-000372-wzwpyvll	640	11	for	for	IN
cord-000372-wzwpyvll	640	12	factors	factor	NNS
cord-000372-wzwpyvll	640	13	involved	involve	VBN
cord-000372-wzwpyvll	640	14	in	in	IN
cord-000372-wzwpyvll	640	15	mRNA	mRNA	NNP
cord-000372-wzwpyvll	640	16	export	export	NN
cord-000372-wzwpyvll	640	17	and	and	CC
cord-000372-wzwpyvll	640	18	nonsense	nonsense	NN
cord-000372-wzwpyvll	640	19	-	-	HYPH
cord-000372-wzwpyvll	640	20	mediated	mediate	VBN
cord-000372-wzwpyvll	640	21	mRNA	mrna	NN
cord-000372-wzwpyvll	640	22	decay	decay	VB
cord-000372-wzwpyvll	640	23	Magoh	Magoh	NNP
cord-000372-wzwpyvll	640	24	,	,	,
cord-000372-wzwpyvll	640	25	a	a	DT
cord-000372-wzwpyvll	640	26	human	human	JJ
cord-000372-wzwpyvll	640	27	homolog	homolog	NN
cord-000372-wzwpyvll	640	28	of	of	IN
cord-000372-wzwpyvll	640	29	Drosophila	Drosophila	NNP
cord-000372-wzwpyvll	640	30	mago	mago	NNP
cord-000372-wzwpyvll	640	31	nashi	nashi	NNP
cord-000372-wzwpyvll	640	32	protein	protein	NN
cord-000372-wzwpyvll	640	33	,	,	,
cord-000372-wzwpyvll	640	34	is	be	VBZ
cord-000372-wzwpyvll	640	35	a	a	DT
cord-000372-wzwpyvll	640	36	component	component	NN
cord-000372-wzwpyvll	640	37	of	of	IN
cord-000372-wzwpyvll	640	38	the	the	DT
cord-000372-wzwpyvll	640	39	splicing	splicing	NN
cord-000372-wzwpyvll	640	40	-	-	HYPH
cord-000372-wzwpyvll	640	41	dependent	dependent	JJ
cord-000372-wzwpyvll	640	42	exon	exon	NN
cord-000372-wzwpyvll	640	43	-	-	HYPH
cord-000372-wzwpyvll	640	44	exon	exon	NN
cord-000372-wzwpyvll	640	45	junction	junction	NN
cord-000372-wzwpyvll	640	46	complex	complex	NN
cord-000372-wzwpyvll	640	47	A	a	DT
cord-000372-wzwpyvll	640	48	Ranindependent	Ranindependent	NNP
cord-000372-wzwpyvll	640	49	pathway	pathway	NN
cord-000372-wzwpyvll	640	50	for	for	IN
cord-000372-wzwpyvll	640	51	export	export	NN
cord-000372-wzwpyvll	640	52	of	of	IN
cord-000372-wzwpyvll	640	53	spliced	splice	VBN
cord-000372-wzwpyvll	640	54	mRNA	mRNA	NNP
cord-000372-wzwpyvll	640	55	Delineation	Delineation	NNP
cord-000372-wzwpyvll	640	56	of	of	IN
cord-000372-wzwpyvll	640	57	mRNA	mRNA	NNP
cord-000372-wzwpyvll	640	58	export	export	NN
cord-000372-wzwpyvll	640	59	pathways	pathway	NNS
cord-000372-wzwpyvll	640	60	by	by	IN
cord-000372-wzwpyvll	640	61	the	the	DT
cord-000372-wzwpyvll	640	62	use	use	NN
cord-000372-wzwpyvll	640	63	of	of	IN
cord-000372-wzwpyvll	640	64	cell	cell	NN
cord-000372-wzwpyvll	640	65	-	-	HYPH
cord-000372-wzwpyvll	640	66	permeable	permeable	JJ
cord-000372-wzwpyvll	640	67	peptides	peptide	NNS
cord-000372-wzwpyvll	640	68	Viral	viral	JJ
cord-000372-wzwpyvll	640	69	ribonucleoprotein	ribonucleoprotein	NN
cord-000372-wzwpyvll	640	70	complex	complex	JJ
cord-000372-wzwpyvll	640	71	formation	formation	NN
cord-000372-wzwpyvll	640	72	and	and	CC
cord-000372-wzwpyvll	640	73	nucleolar	nucleolar	JJ
cord-000372-wzwpyvll	640	74	-	-	HYPH
cord-000372-wzwpyvll	640	75	cytoplasmic	cytoplasmic	JJ
cord-000372-wzwpyvll	640	76	relocalization	relocalization	NN
cord-000372-wzwpyvll	640	77	of	of	IN
cord-000372-wzwpyvll	640	78	nucleolin	nucleolin	NNP
cord-000372-wzwpyvll	640	79	in	in	IN
cord-000372-wzwpyvll	640	80	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	640	81	-	-	HYPH
cord-000372-wzwpyvll	640	82	infected	infect	VBN
cord-000372-wzwpyvll	640	83	cells	cell	NNS
cord-000372-wzwpyvll	640	84	Inhibition	inhibition	NN
cord-000372-wzwpyvll	640	85	of	of	IN
cord-000372-wzwpyvll	640	86	nucleo	nucleo	JJ
cord-000372-wzwpyvll	640	87	-	-	JJ
cord-000372-wzwpyvll	640	88	cytoplasmic	cytoplasmic	JJ
cord-000372-wzwpyvll	640	89	trafficking	trafficking	NN
cord-000372-wzwpyvll	640	90	by	by	IN
cord-000372-wzwpyvll	640	91	RNA	RNA	NNP
cord-000372-wzwpyvll	640	92	viruses	virus	NNS
cord-000372-wzwpyvll	640	93	:	:	:
cord-000372-wzwpyvll	640	94	targeting	target	VBG
cord-000372-wzwpyvll	640	95	the	the	DT
cord-000372-wzwpyvll	640	96	nuclear	nuclear	JJ
cord-000372-wzwpyvll	640	97	pore	pore	NN
cord-000372-wzwpyvll	640	98	complex	complex	NN
cord-000372-wzwpyvll	640	99	A	a	DT
cord-000372-wzwpyvll	640	100	cellular	cellular	JJ
cord-000372-wzwpyvll	640	101	protein	protein	NN
cord-000372-wzwpyvll	640	102	that	that	WDT
cord-000372-wzwpyvll	640	103	binds	bind	VBZ
cord-000372-wzwpyvll	640	104	to	to	IN
cord-000372-wzwpyvll	640	105	the	the	DT
cord-000372-wzwpyvll	640	106	5'-noncoding	5'-noncoding	NNP
cord-000372-wzwpyvll	640	107	region	region	NN
cord-000372-wzwpyvll	640	108	of	of	IN
cord-000372-wzwpyvll	640	109	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	640	110	RNA	RNA	NNP
cord-000372-wzwpyvll	640	111	:	:	:
cord-000372-wzwpyvll	640	112	implications	implication	NNS
cord-000372-wzwpyvll	640	113	for	for	IN
cord-000372-wzwpyvll	640	114	internal	internal	JJ
cord-000372-wzwpyvll	640	115	translation	translation	NN
cord-000372-wzwpyvll	640	116	initiation	initiation	NN
cord-000372-wzwpyvll	641	1	A	a	DT
cord-000372-wzwpyvll	641	2	cytoplasmic	cytoplasmic	JJ
cord-000372-wzwpyvll	641	3	57-kDa	57-kda	CD
cord-000372-wzwpyvll	641	4	protein	protein	NN
cord-000372-wzwpyvll	641	5	that	that	WDT
cord-000372-wzwpyvll	641	6	is	be	VBZ
cord-000372-wzwpyvll	641	7	required	require	VBN
cord-000372-wzwpyvll	641	8	for	for	IN
cord-000372-wzwpyvll	641	9	translation	translation	NN
cord-000372-wzwpyvll	641	10	of	of	IN
cord-000372-wzwpyvll	641	11	picornavirus	picornavirus	NNP
cord-000372-wzwpyvll	641	12	RNA	RNA	NNP
cord-000372-wzwpyvll	641	13	by	by	IN
cord-000372-wzwpyvll	641	14	internal	internal	JJ
cord-000372-wzwpyvll	641	15	ribosomal	ribosomal	JJ
cord-000372-wzwpyvll	641	16	entry	entry	NN
cord-000372-wzwpyvll	641	17	is	be	VBZ
cord-000372-wzwpyvll	641	18	identical	identical	JJ
cord-000372-wzwpyvll	641	19	to	to	IN
cord-000372-wzwpyvll	641	20	the	the	DT
cord-000372-wzwpyvll	641	21	nuclear	nuclear	JJ
cord-000372-wzwpyvll	641	22	pyrimidine	pyrimidine	NN
cord-000372-wzwpyvll	641	23	tract	tract	NN
cord-000372-wzwpyvll	641	24	-	-	HYPH
cord-000372-wzwpyvll	641	25	binding	bind	VBG
cord-000372-wzwpyvll	641	26	protein	protein	NN
cord-000372-wzwpyvll	641	27	Human	Human	NNP
cord-000372-wzwpyvll	641	28	protein	protein	NN
cord-000372-wzwpyvll	641	29	Sam68	Sam68	NNP
cord-000372-wzwpyvll	641	30	relocalization	relocalization	NN
cord-000372-wzwpyvll	641	31	and	and	CC
cord-000372-wzwpyvll	641	32	interaction	interaction	NN
cord-000372-wzwpyvll	641	33	with	with	IN
cord-000372-wzwpyvll	641	34	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	641	35	RNA	RNA	NNP
cord-000372-wzwpyvll	641	36	polymerase	polymerase	NN
cord-000372-wzwpyvll	641	37	in	in	IN
cord-000372-wzwpyvll	641	38	infected	infected	JJ
cord-000372-wzwpyvll	641	39	cells	cell	NNS
cord-000372-wzwpyvll	642	1	Intracellular	intracellular	JJ
cord-000372-wzwpyvll	642	2	redistribution	redistribution	NN
cord-000372-wzwpyvll	642	3	of	of	IN
cord-000372-wzwpyvll	642	4	truncated	truncated	JJ
cord-000372-wzwpyvll	642	5	La	La	NNP
cord-000372-wzwpyvll	642	6	protein	protein	NN
cord-000372-wzwpyvll	642	7	produced	produce	VBN
cord-000372-wzwpyvll	642	8	by	by	IN
cord-000372-wzwpyvll	642	9	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	643	1	3C(pro)-mediated	3c(pro)-mediate	VBN
cord-000372-wzwpyvll	643	2	cleavage	cleavage	NN
cord-000372-wzwpyvll	643	3	KH	KH	NNP
cord-000372-wzwpyvll	643	4	domain	domain	NN
cord-000372-wzwpyvll	643	5	integrity	integrity	NN
cord-000372-wzwpyvll	643	6	is	be	VBZ
cord-000372-wzwpyvll	643	7	required	require	VBN
cord-000372-wzwpyvll	643	8	for	for	IN
cord-000372-wzwpyvll	643	9	wild	wild	JJ
cord-000372-wzwpyvll	643	10	-	-	HYPH
cord-000372-wzwpyvll	643	11	type	type	NN
cord-000372-wzwpyvll	643	12	localization	localization	NN
cord-000372-wzwpyvll	643	13	of	of	IN
cord-000372-wzwpyvll	643	14	Sam68	Sam68	NNP
cord-000372-wzwpyvll	643	15	Translation	Translation	NNP
cord-000372-wzwpyvll	643	16	of	of	IN
cord-000372-wzwpyvll	643	17	polioviral	polioviral	NNP
cord-000372-wzwpyvll	643	18	mRNA	mRNA	NNP
cord-000372-wzwpyvll	643	19	is	be	VBZ
cord-000372-wzwpyvll	643	20	inhibited	inhibit	VBN
cord-000372-wzwpyvll	643	21	by	by	IN
cord-000372-wzwpyvll	643	22	cleavage	cleavage	NN
cord-000372-wzwpyvll	643	23	of	of	IN
cord-000372-wzwpyvll	643	24	polypyrimidine	polypyrimidine	JJ
cord-000372-wzwpyvll	643	25	tractbinding	tractbinding	NN
cord-000372-wzwpyvll	643	26	proteins	protein	NNS
cord-000372-wzwpyvll	643	27	executed	execute	VBN
cord-000372-wzwpyvll	643	28	by	by	IN
cord-000372-wzwpyvll	643	29	polioviral	polioviral	NNP
cord-000372-wzwpyvll	643	30	3C(pro	3c(pro	CD
cord-000372-wzwpyvll	643	31	)	)	-RRB-
cord-000372-wzwpyvll	644	1	Bidirectional	bidirectional	JJ
cord-000372-wzwpyvll	644	2	increase	increase	NN
cord-000372-wzwpyvll	644	3	in	in	IN
cord-000372-wzwpyvll	644	4	permeability	permeability	NN
cord-000372-wzwpyvll	644	5	of	of	IN
cord-000372-wzwpyvll	644	6	nuclear	nuclear	JJ
cord-000372-wzwpyvll	644	7	envelope	envelope	NN
cord-000372-wzwpyvll	644	8	upon	upon	IN
cord-000372-wzwpyvll	644	9	poliovirus	poliovirus	NN
cord-000372-wzwpyvll	644	10	infection	infection	NN
cord-000372-wzwpyvll	644	11	and	and	CC
cord-000372-wzwpyvll	644	12	accompanying	accompany	VBG
cord-000372-wzwpyvll	644	13	alterations	alteration	NNS
cord-000372-wzwpyvll	644	14	of	of	IN
cord-000372-wzwpyvll	644	15	nuclear	nuclear	JJ
cord-000372-wzwpyvll	644	16	pores	pore	NNS
cord-000372-wzwpyvll	645	1	Cytoplasmic	Cytoplasmic	NNP
cord-000372-wzwpyvll	645	2	nucleic	nucleic	JJ
cord-000372-wzwpyvll	645	3	acid	acid	NN
cord-000372-wzwpyvll	645	4	sensors	sensor	NNS
cord-000372-wzwpyvll	645	5	in	in	IN
cord-000372-wzwpyvll	645	6	antiviral	antiviral	JJ
cord-000372-wzwpyvll	645	7	immunity	immunity	NN
cord-000372-wzwpyvll	645	8	Versatility	versatility	NN
cord-000372-wzwpyvll	645	9	at	at	IN
cord-000372-wzwpyvll	645	10	the	the	DT
cord-000372-wzwpyvll	645	11	nuclear	nuclear	JJ
cord-000372-wzwpyvll	645	12	pore	pore	NN
cord-000372-wzwpyvll	645	13	complex	complex	NN
cord-000372-wzwpyvll	645	14	:	:	:
cord-000372-wzwpyvll	645	15	lessons	lesson	NNS
cord-000372-wzwpyvll	645	16	learned	learn	VBN
cord-000372-wzwpyvll	645	17	from	from	IN
cord-000372-wzwpyvll	645	18	the	the	DT
cord-000372-wzwpyvll	645	19	nucleoporin	nucleoporin	NNP
cord-000372-wzwpyvll	645	20	Nup153	Nup153	.
cord-000372-wzwpyvll	646	1	Caspasedependent	Caspasedependent	NNP
cord-000372-wzwpyvll	646	2	proteolysis	proteolysis	NN
cord-000372-wzwpyvll	646	3	of	of	IN
cord-000372-wzwpyvll	646	4	integral	integral	JJ
cord-000372-wzwpyvll	646	5	and	and	CC
cord-000372-wzwpyvll	646	6	peripheral	peripheral	JJ
cord-000372-wzwpyvll	646	7	proteins	protein	NNS
cord-000372-wzwpyvll	646	8	of	of	IN
cord-000372-wzwpyvll	646	9	nuclear	nuclear	JJ
cord-000372-wzwpyvll	646	10	membranes	membrane	NNS
cord-000372-wzwpyvll	646	11	and	and	CC
cord-000372-wzwpyvll	646	12	nuclear	nuclear	JJ
cord-000372-wzwpyvll	646	13	pore	pore	NN
cord-000372-wzwpyvll	646	14	complex	complex	NN
cord-000372-wzwpyvll	646	15	proteins	protein	NNS
cord-000372-wzwpyvll	646	16	during	during	IN
cord-000372-wzwpyvll	646	17	apoptosis	apoptosis	NN
cord-000372-wzwpyvll	646	18	Specific	specific	JJ
cord-000372-wzwpyvll	646	19	cleavage	cleavage	NN
cord-000372-wzwpyvll	646	20	of	of	IN
cord-000372-wzwpyvll	646	21	the	the	DT
cord-000372-wzwpyvll	646	22	nuclear	nuclear	JJ
cord-000372-wzwpyvll	646	23	pore	pore	NN
cord-000372-wzwpyvll	646	24	complex	complex	NN
cord-000372-wzwpyvll	646	25	protein	protein	NN
cord-000372-wzwpyvll	646	26	Nup62	Nup62	NNP
cord-000372-wzwpyvll	646	27	by	by	IN
cord-000372-wzwpyvll	646	28	a	a	DT
cord-000372-wzwpyvll	646	29	viral	viral	JJ
cord-000372-wzwpyvll	646	30	protease	protease	NN
cord-000372-wzwpyvll	646	31	Role	role	NN
cord-000372-wzwpyvll	646	32	of	of	IN
cord-000372-wzwpyvll	646	33	nucleoporin	nucleoporin	NNP
cord-000372-wzwpyvll	646	34	induction	induction	NN
cord-000372-wzwpyvll	646	35	in	in	IN
cord-000372-wzwpyvll	646	36	releasing	release	VBG
cord-000372-wzwpyvll	646	37	an	an	DT
cord-000372-wzwpyvll	646	38	mRNA	mRNA	NNP
cord-000372-wzwpyvll	646	39	nuclear	nuclear	JJ
cord-000372-wzwpyvll	646	40	export	export	NN
cord-000372-wzwpyvll	646	41	block	block	NN
cord-000372-wzwpyvll	646	42	Nucleocytoplasmic	Nucleocytoplasmic	NNP
cord-000372-wzwpyvll	646	43	traffic	traffic	NN
cord-000372-wzwpyvll	646	44	disorder	disorder	NN
cord-000372-wzwpyvll	646	45	induced	induce	VBN
cord-000372-wzwpyvll	646	46	by	by	IN
cord-000372-wzwpyvll	646	47	cardioviruses	cardioviruses	NNP
cord-000372-wzwpyvll	647	1	A	a	DT
cord-000372-wzwpyvll	647	2	picornavirus	picornavirus	NN
cord-000372-wzwpyvll	647	3	protein	protein	NN
cord-000372-wzwpyvll	647	4	interacts	interact	VBZ
cord-000372-wzwpyvll	647	5	with	with	IN
cord-000372-wzwpyvll	647	6	Ran	Ran	NNP
cord-000372-wzwpyvll	647	7	-	-	HYPH
cord-000372-wzwpyvll	647	8	GTPase	GTPase	NNP
cord-000372-wzwpyvll	647	9	and	and	CC
cord-000372-wzwpyvll	647	10	disrupts	disrupt	VBZ
cord-000372-wzwpyvll	647	11	nucleocytoplasmic	nucleocytoplasmic	NNP
cord-000372-wzwpyvll	647	12	transport	transport	NN
cord-000372-wzwpyvll	647	13	Leader	Leader	NNP
cord-000372-wzwpyvll	647	14	protein	protein	NN
cord-000372-wzwpyvll	647	15	of	of	IN
cord-000372-wzwpyvll	647	16	encephalomyocarditis	encephalomyocarditis	NNP
cord-000372-wzwpyvll	647	17	virus	virus	NN
cord-000372-wzwpyvll	647	18	binds	bind	VBZ
cord-000372-wzwpyvll	647	19	zinc	zinc	NN
cord-000372-wzwpyvll	647	20	,	,	,
cord-000372-wzwpyvll	647	21	is	be	VBZ
cord-000372-wzwpyvll	647	22	phosphorylated	phosphorylate	VBN
cord-000372-wzwpyvll	647	23	during	during	IN
cord-000372-wzwpyvll	647	24	viral	viral	JJ
cord-000372-wzwpyvll	647	25	infection	infection	NN
cord-000372-wzwpyvll	647	26	,	,	,
cord-000372-wzwpyvll	647	27	and	and	CC
cord-000372-wzwpyvll	647	28	affects	affect	VBZ
cord-000372-wzwpyvll	647	29	the	the	DT
cord-000372-wzwpyvll	647	30	efficiency	efficiency	NN
cord-000372-wzwpyvll	647	31	of	of	IN
cord-000372-wzwpyvll	647	32	genome	genome	NN
cord-000372-wzwpyvll	647	33	translation	translation	NN
cord-000372-wzwpyvll	647	34	Inhibition	inhibition	NN
cord-000372-wzwpyvll	647	35	of	of	IN
cord-000372-wzwpyvll	647	36	ran	ran	NN
cord-000372-wzwpyvll	647	37	guanosine	guanosine	NN
cord-000372-wzwpyvll	647	38	triphosphatase	triphosphatase	NN
cord-000372-wzwpyvll	647	39	-	-	HYPH
cord-000372-wzwpyvll	647	40	dependent	dependent	JJ
cord-000372-wzwpyvll	647	41	nuclear	nuclear	JJ
cord-000372-wzwpyvll	647	42	transport	transport	NN
cord-000372-wzwpyvll	647	43	by	by	IN
cord-000372-wzwpyvll	647	44	the	the	DT
cord-000372-wzwpyvll	647	45	matrix	matrix	NN
cord-000372-wzwpyvll	647	46	protein	protein	NN
cord-000372-wzwpyvll	647	47	of	of	IN
cord-000372-wzwpyvll	647	48	vesicular	vesicular	JJ
cord-000372-wzwpyvll	647	49	stomatitis	stomatitis	NN
cord-000372-wzwpyvll	647	50	virus	virus	NN
cord-000372-wzwpyvll	647	51	VSV	VSV	NNP
cord-000372-wzwpyvll	647	52	disrupts	disrupt	VBZ
cord-000372-wzwpyvll	647	53	the	the	DT
cord-000372-wzwpyvll	647	54	Rae1	Rae1	NNP
cord-000372-wzwpyvll	647	55	/	/	SYM
cord-000372-wzwpyvll	647	56	mrnp41	mrnp41	NN
cord-000372-wzwpyvll	647	57	mRNA	mRNA	NNP
cord-000372-wzwpyvll	647	58	nuclear	nuclear	JJ
cord-000372-wzwpyvll	647	59	export	export	NN
cord-000372-wzwpyvll	647	60	pathway	pathway	NN
cord-000372-wzwpyvll	647	61	Influenza	Influenza	NNP
cord-000372-wzwpyvll	647	62	virus	virus	NN
cord-000372-wzwpyvll	647	63	NS1	ns1	CD
cord-000372-wzwpyvll	647	64	protein	protein	NN
cord-000372-wzwpyvll	648	1	inhibits	inhibit	VBZ
cord-000372-wzwpyvll	648	2	pre	pre	JJ
cord-000372-wzwpyvll	648	3	-	-	JJ
cord-000372-wzwpyvll	648	4	mRNA	mrna	JJ
cord-000372-wzwpyvll	648	5	splicing	splicing	NN
cord-000372-wzwpyvll	648	6	and	and	CC
cord-000372-wzwpyvll	648	7	blocks	block	NNS
cord-000372-wzwpyvll	649	1	mRNA	mRNA	NNP
cord-000372-wzwpyvll	650	1	nucleocytoplasmic	nucleocytoplasmic	NNP
cord-000372-wzwpyvll	650	2	transport	transport	NN
cord-000372-wzwpyvll	650	3	RIG	rig	NN
cord-000372-wzwpyvll	650	4	-	-	:
cord-000372-wzwpyvll	650	5	I	i	NN
cord-000372-wzwpyvll	650	6	-	-	HYPH
cord-000372-wzwpyvll	650	7	mediated	mediate	VBN
cord-000372-wzwpyvll	650	8	antiviral	antiviral	JJ
cord-000372-wzwpyvll	650	9	responses	response	NNS
cord-000372-wzwpyvll	650	10	to	to	IN
cord-000372-wzwpyvll	650	11	single	single	RB
cord-000372-wzwpyvll	650	12	-	-	HYPH
cord-000372-wzwpyvll	650	13	stranded	strand	VBN
cord-000372-wzwpyvll	650	14	RNA	RNA	NNP
cord-000372-wzwpyvll	650	15	bearing	bear	VBG
cord-000372-wzwpyvll	650	16	5	5	CD
cord-000372-wzwpyvll	650	17	-phosphates	-phosphate	NNS
cord-000372-wzwpyvll	650	18	Inhibition	inhibition	NN
cord-000372-wzwpyvll	650	19	of	of	IN
cord-000372-wzwpyvll	650	20	retinoic	retinoic	JJ
cord-000372-wzwpyvll	650	21	acid	acid	NN
cord-000372-wzwpyvll	650	22	-	-	HYPH
cord-000372-wzwpyvll	650	23	inducible	inducible	JJ
cord-000372-wzwpyvll	650	24	gene	gene	NN
cord-000372-wzwpyvll	650	25	I	i	NN
cord-000372-wzwpyvll	650	26	-	-	HYPH
cord-000372-wzwpyvll	650	27	mediated	mediate	VBN
cord-000372-wzwpyvll	650	28	induction	induction	NN
cord-000372-wzwpyvll	650	29	of	of	IN
cord-000372-wzwpyvll	650	30	beta	beta	NN
cord-000372-wzwpyvll	650	31	interferon	interferon	NN
cord-000372-wzwpyvll	650	32	by	by	IN
cord-000372-wzwpyvll	650	33	the	the	DT
cord-000372-wzwpyvll	650	34	NS1	ns1	NN
cord-000372-wzwpyvll	650	35	protein	protein	NN
cord-000372-wzwpyvll	650	36	of	of	IN
cord-000372-wzwpyvll	650	37	influenza	influenza	NN
cord-000372-wzwpyvll	650	38	A	a	DT
cord-000372-wzwpyvll	650	39	virus	virus	NN
cord-000372-wzwpyvll	651	1	Gemin8	Gemin8	NNP
cord-000372-wzwpyvll	651	2	is	be	VBZ
cord-000372-wzwpyvll	651	3	a	a	DT
cord-000372-wzwpyvll	651	4	novel	novel	JJ
cord-000372-wzwpyvll	651	5	component	component	NN
cord-000372-wzwpyvll	651	6	of	of	IN
cord-000372-wzwpyvll	651	7	the	the	DT
cord-000372-wzwpyvll	651	8	survival	survival	NN
cord-000372-wzwpyvll	651	9	motor	motor	NN
cord-000372-wzwpyvll	651	10	neuron	neuron	NN
cord-000372-wzwpyvll	651	11	complex	complex	NN
cord-000372-wzwpyvll	651	12	and	and	CC
cord-000372-wzwpyvll	651	13	functions	function	NNS
cord-000372-wzwpyvll	651	14	in	in	IN
cord-000372-wzwpyvll	651	15	small	small	JJ
cord-000372-wzwpyvll	651	16	nuclear	nuclear	JJ
cord-000372-wzwpyvll	651	17	ribonucleoprotein	ribonucleoprotein	NN
cord-000372-wzwpyvll	651	18	assembly	assembly	NN
cord-000372-wzwpyvll	651	19	Gemin8	Gemin8	NNP
cord-000372-wzwpyvll	651	20	is	be	VBZ
cord-000372-wzwpyvll	651	21	required	require	VBN
cord-000372-wzwpyvll	651	22	for	for	IN
cord-000372-wzwpyvll	651	23	the	the	DT
cord-000372-wzwpyvll	651	24	architecture	architecture	NN
cord-000372-wzwpyvll	651	25	and	and	CC
cord-000372-wzwpyvll	651	26	function	function	NN
cord-000372-wzwpyvll	651	27	of	of	IN
cord-000372-wzwpyvll	651	28	the	the	DT
cord-000372-wzwpyvll	651	29	survival	survival	NN
cord-000372-wzwpyvll	651	30	motor	motor	NN
cord-000372-wzwpyvll	651	31	neuron	neuron	NN
cord-000372-wzwpyvll	651	32	complex	complex	NN
cord-000372-wzwpyvll	652	1	A	a	DT
cord-000372-wzwpyvll	652	2	multiprotein	multiprotein	NN
cord-000372-wzwpyvll	652	3	complex	complex	NN
cord-000372-wzwpyvll	652	4	mediates	mediate	VBZ
cord-000372-wzwpyvll	652	5	the	the	DT
cord-000372-wzwpyvll	652	6	ATP	ATP	NNP
cord-000372-wzwpyvll	652	7	-	-	HYPH
cord-000372-wzwpyvll	652	8	dependent	dependent	JJ
cord-000372-wzwpyvll	652	9	assembly	assembly	NN
cord-000372-wzwpyvll	652	10	of	of	IN
cord-000372-wzwpyvll	652	11	spliceosomal	spliceosomal	NNP
cord-000372-wzwpyvll	653	1	U	U	NNP
cord-000372-wzwpyvll	653	2	snRNPs	snrnps	RB
cord-000372-wzwpyvll	654	1	SMNrp	SMNrp	NNP
cord-000372-wzwpyvll	654	2	is	be	VBZ
cord-000372-wzwpyvll	654	3	an	an	DT
cord-000372-wzwpyvll	654	4	essential	essential	JJ
cord-000372-wzwpyvll	654	5	pre	pre	JJ
cord-000372-wzwpyvll	654	6	-	-	JJ
cord-000372-wzwpyvll	654	7	mRNA	mrna	JJ
cord-000372-wzwpyvll	654	8	splicing	splicing	NN
cord-000372-wzwpyvll	654	9	factor	factor	NN
cord-000372-wzwpyvll	654	10	required	require	VBN
cord-000372-wzwpyvll	654	11	for	for	IN
cord-000372-wzwpyvll	654	12	the	the	DT
cord-000372-wzwpyvll	654	13	formation	formation	NN
cord-000372-wzwpyvll	654	14	of	of	IN
cord-000372-wzwpyvll	654	15	the	the	DT
cord-000372-wzwpyvll	654	16	mature	mature	JJ
cord-000372-wzwpyvll	654	17	spliceosome	spliceosome	NN
cord-000372-wzwpyvll	654	18	Specific	specific	JJ
cord-000372-wzwpyvll	654	19	sequence	sequence	NN
cord-000372-wzwpyvll	654	20	features	feature	VBZ
cord-000372-wzwpyvll	654	21	,	,	,
cord-000372-wzwpyvll	654	22	recognized	recognize	VBN
cord-000372-wzwpyvll	654	23	by	by	IN
cord-000372-wzwpyvll	654	24	the	the	DT
cord-000372-wzwpyvll	654	25	SMN	SMN	NNP
cord-000372-wzwpyvll	654	26	complex	complex	NN
cord-000372-wzwpyvll	654	27	,	,	,
cord-000372-wzwpyvll	654	28	identify	identify	VB
cord-000372-wzwpyvll	654	29	snRNAs	snrna	NNS
cord-000372-wzwpyvll	654	30	and	and	CC
cord-000372-wzwpyvll	654	31	determine	determine	VB
cord-000372-wzwpyvll	654	32	their	-PRON-	PRP$
cord-000372-wzwpyvll	654	33	fate	fate	NN
cord-000372-wzwpyvll	654	34	as	as	IN
cord-000372-wzwpyvll	654	35	snRNPs	snrnps	JJ
cord-000372-wzwpyvll	654	36	Biogenesis	Biogenesis	NNP
cord-000372-wzwpyvll	654	37	of	of	IN
cord-000372-wzwpyvll	654	38	small	small	JJ
cord-000372-wzwpyvll	654	39	nuclear	nuclear	JJ
cord-000372-wzwpyvll	654	40	RNPs	rnp	NNS
cord-000372-wzwpyvll	654	41	Inhibition	Inhibition	NNP
cord-000372-wzwpyvll	654	42	of	of	IN
cord-000372-wzwpyvll	654	43	U	U	NNP
cord-000372-wzwpyvll	654	44	snRNP	snrnp	NN
cord-000372-wzwpyvll	654	45	assembly	assembly	NN
cord-000372-wzwpyvll	654	46	by	by	IN
cord-000372-wzwpyvll	654	47	a	a	DT
cord-000372-wzwpyvll	654	48	virus	virus	NN
cord-000372-wzwpyvll	654	49	-	-	HYPH
cord-000372-wzwpyvll	654	50	encoded	encode	VBN
cord-000372-wzwpyvll	654	51	proteinase	proteinase	NN
cord-000372-wzwpyvll	654	52	Poliovirusencoded	Poliovirusencoded	NNP
cord-000372-wzwpyvll	654	53	protease	protease	NN
cord-000372-wzwpyvll	654	54	2A(Pro	2a(pro	CD
cord-000372-wzwpyvll	654	55	)	)	-RRB-
cord-000372-wzwpyvll	655	1	cleaves	cleave	VBZ
cord-000372-wzwpyvll	655	2	the	the	DT
cord-000372-wzwpyvll	655	3	TATA	TATA	NNP
cord-000372-wzwpyvll	655	4	-	-	HYPH
cord-000372-wzwpyvll	655	5	binding	bind	VBG
cord-000372-wzwpyvll	655	6	protein	protein	NN
cord-000372-wzwpyvll	655	7	but	but	CC
cord-000372-wzwpyvll	655	8	does	do	VBZ
cord-000372-wzwpyvll	655	9	not	not	RB
cord-000372-wzwpyvll	655	10	inhibit	inhibit	VB
cord-000372-wzwpyvll	655	11	host	host	NN
cord-000372-wzwpyvll	655	12	cell	cell	NN
cord-000372-wzwpyvll	655	13	RNA	RNA	NNP
cord-000372-wzwpyvll	655	14	polymerase	polymerase	NN
cord-000372-wzwpyvll	655	15	II	ii	CD
cord-000372-wzwpyvll	655	16	transcription	transcription	NN
cord-000372-wzwpyvll	655	17	in	in	IN
cord-000372-wzwpyvll	655	18	vitro	vitro	FW
cord-000372-wzwpyvll	656	1	The	the	DT
cord-000372-wzwpyvll	656	2	interaction	interaction	NN
cord-000372-wzwpyvll	656	3	of	of	IN
cord-000372-wzwpyvll	656	4	cytoplasmic	cytoplasmic	JJ
cord-000372-wzwpyvll	656	5	RNA	RNA	NNP
cord-000372-wzwpyvll	656	6	viruses	virus	NNS
cord-000372-wzwpyvll	656	7	with	with	IN
cord-000372-wzwpyvll	656	8	the	the	DT
cord-000372-wzwpyvll	656	9	nucleus	nucleus	NN
cord-000372-wzwpyvll	656	10	Cleavage	Cleavage	NNP
cord-000372-wzwpyvll	656	11	site	site	NN
cord-000372-wzwpyvll	656	12	analysis	analysis	NN
cord-000372-wzwpyvll	656	13	in	in	IN
cord-000372-wzwpyvll	656	14	picornaviral	picornaviral	NNP
cord-000372-wzwpyvll	656	15	polyproteins	polyproteins	NNP
cord-000372-wzwpyvll	656	16	:	:	:
cord-000372-wzwpyvll	656	17	discovering	discover	VBG
cord-000372-wzwpyvll	656	18	cellular	cellular	JJ
cord-000372-wzwpyvll	656	19	targets	target	NNS
cord-000372-wzwpyvll	656	20	by	by	IN
cord-000372-wzwpyvll	656	21	neural	neural	JJ
cord-000372-wzwpyvll	656	22	networks	network	NNS
cord-000372-wzwpyvll	657	1	Enteroviral	enteroviral	JJ
cord-000372-wzwpyvll	657	2	protease	protease	NN
cord-000372-wzwpyvll	657	3	2A	2A	NNP
cord-000372-wzwpyvll	657	4	cleaves	cleave	VBZ
cord-000372-wzwpyvll	657	5	dystrophin	dystrophin	NN
cord-000372-wzwpyvll	657	6	:	:	:
cord-000372-wzwpyvll	657	7	evidence	evidence	NN
cord-000372-wzwpyvll	657	8	of	of	IN
cord-000372-wzwpyvll	657	9	cytoskeletal	cytoskeletal	JJ
cord-000372-wzwpyvll	657	10	disruption	disruption	NN
cord-000372-wzwpyvll	657	11	in	in	IN
cord-000372-wzwpyvll	657	12	an	an	DT
cord-000372-wzwpyvll	657	13	acquired	acquire	VBN
cord-000372-wzwpyvll	657	14	cardiomyopathy	cardiomyopathy	NN
cord-000372-wzwpyvll	657	15	2A	2a	CD
cord-000372-wzwpyvll	657	16	proteinase	proteinase	NN
cord-000372-wzwpyvll	657	17	of	of	IN
cord-000372-wzwpyvll	657	18	human	human	JJ
cord-000372-wzwpyvll	657	19	rhinovirus	rhinovirus	NN
cord-000372-wzwpyvll	657	20	cleaves	cleave	VBZ
cord-000372-wzwpyvll	657	21	cytokeratin	cytokeratin	NNP
cord-000372-wzwpyvll	657	22	8	8	CD
cord-000372-wzwpyvll	657	23	in	in	IN
cord-000372-wzwpyvll	657	24	infected	infected	JJ
cord-000372-wzwpyvll	657	25	HeLa	HeLa	NNP
cord-000372-wzwpyvll	657	26	cells	cell	NNS
cord-000372-wzwpyvll	658	1	Our	-PRON-	PRP$
cord-000372-wzwpyvll	658	2	group	group	NN
cord-000372-wzwpyvll	658	3	is	be	VBZ
cord-000372-wzwpyvll	658	4	supported	support	VBN
cord-000372-wzwpyvll	658	5	by	by	IN
cord-000372-wzwpyvll	658	6	a	a	DT
cord-000372-wzwpyvll	658	7	DGICYT	DGICYT	NNP
cord-000372-wzwpyvll	658	8	Grant	Grant	NNP
cord-000372-wzwpyvll	658	9	(	(	-LRB-
cord-000372-wzwpyvll	658	10	no	no	UH
cord-000372-wzwpyvll	658	11	.	.	.
cord-000372-wzwpyvll	659	1	BFU2009	bfu2009	NN
cord-000372-wzwpyvll	659	2	-	-	HYPH
cord-000372-wzwpyvll	659	3	07352	07352	CD
cord-000372-wzwpyvll	659	4	)	)	-RRB-
cord-000372-wzwpyvll	659	5	.	.	.
cord-000372-wzwpyvll	660	1	The	the	DT
cord-000372-wzwpyvll	660	2	Institutional	Institutional	NNP
cord-000372-wzwpyvll	660	3	Grant	Grant	NNP
cord-000372-wzwpyvll	660	4	awarded	award	VBD
cord-000372-wzwpyvll	660	5	to	to	IN
cord-000372-wzwpyvll	660	6	the	the	DT
cord-000372-wzwpyvll	660	7	Centro	Centro	NNP
cord-000372-wzwpyvll	660	8	de	de	NNP
cord-000372-wzwpyvll	660	9	Biología	Biología	NNP
cord-000372-wzwpyvll	660	10	Molecular	Molecular	NNP
cord-000372-wzwpyvll	660	11	"	"	``
cord-000372-wzwpyvll	660	12	Severo	Severo	NNP
cord-000372-wzwpyvll	660	13	Ochoa	Ochoa	NNP
cord-000372-wzwpyvll	660	14	"	"	''
cord-000372-wzwpyvll	660	15	by	by	IN
cord-000372-wzwpyvll	660	16	the	the	DT
cord-000372-wzwpyvll	660	17	Fundación	Fundación	NNP
cord-000372-wzwpyvll	660	18	Ramón	Ramón	NNP
cord-000372-wzwpyvll	660	19	Areces	Areces	NNP
cord-000372-wzwpyvll	660	20	is	be	VBZ
cord-000372-wzwpyvll	660	21	also	also	RB
cord-000372-wzwpyvll	660	22	acknowledged	acknowledge	VBN
cord-000372-wzwpyvll	660	23	.	.	.
cord-000372-wzwpyvll	661	1	A.	A.	NNP
cord-000372-wzwpyvll	661	2	Castello	Castello	NNP
cord-000372-wzwpyvll	661	3	is	be	VBZ
cord-000372-wzwpyvll	661	4	a	a	DT
cord-000372-wzwpyvll	661	5	beneficiary	beneficiary	NN
cord-000372-wzwpyvll	661	6	of	of	IN
cord-000372-wzwpyvll	661	7	Marie	Marie	NNP
cord-000372-wzwpyvll	661	8	Curie	Curie	NNP
cord-000372-wzwpyvll	661	9	IEF	IEF	NNP
cord-000372-wzwpyvll	661	10	fellowship	fellowship	NN
cord-000372-wzwpyvll	661	11	(	(	-LRB-
cord-000372-wzwpyvll	661	12	Seventh	Seventh	NNP
cord-000372-wzwpyvll	661	13	Framework	Framework	NNP
cord-000372-wzwpyvll	661	14	Programme	Programme	NNP
cord-000372-wzwpyvll	661	15	)	)	-RRB-
cord-000372-wzwpyvll	661	16	.	.	.
cord-000372-wzwpyvll	662	1	Alfredo	Alfredo	NNP
cord-000372-wzwpyvll	662	2	Castelló	Castelló	NNP
cord-000372-wzwpyvll	662	3	and	and	CC
cord-000372-wzwpyvll	662	4	EnriqueÁlvarez	EnriqueÁlvarez	NNP
cord-000372-wzwpyvll	662	5	contributed	contribute	VBD
cord-000372-wzwpyvll	662	6	equally	equally	RB
cord-000372-wzwpyvll	662	7	to	to	IN
cord-000372-wzwpyvll	662	8	this	this	DT
cord-000372-wzwpyvll	662	9	work	work	NN
cord-000372-wzwpyvll	662	10	.	.	.